id	sid	tid	token	lemma	pos
admet-390	1	1	manuscript	manuscript	PROPN
admet-390	1	2	doi	doi	PROPN
admet-390	1	3	:	:	PUNCT
admet-390	1	4	10.5599	10.5599	NUM
admet-390	1	5	/	/	SYM
admet-390	1	6	admet.5.2.390	admet.5.2.390	PROPN
admet-390	1	7	75	75	NUM
admet-390	1	8	admet	admet	X
admet-390	1	9	&	&	CCONJ
admet-390	1	10	dmpk	dmpk	PROPN
admet-390	1	11	5(2	5(2	NUM
admet-390	1	12	)	)	PUNCT
admet-390	1	13	(	(	PUNCT
admet-390	1	14	2017	2017	NUM
admet-390	1	15	)	)	PUNCT
admet-390	1	16	75	75	NUM
admet-390	1	17	-	-	SYM
admet-390	1	18	84	84	NUM
admet-390	1	19	;	;	PUNCT
admet-390	1	20	doi	doi	NOUN
admet-390	1	21	:	:	PUNCT
admet-390	1	22	10.5599	10.5599	NUM
admet-390	1	23	/	/	SYM
admet-390	1	24	admet.5.2.390	admet.5.2.390	NOUN
admet-390	1	25	open	open	ADJ
admet-390	1	26	access	access	NOUN
admet-390	1	27	:	:	PUNCT
admet-390	1	28	issn	issn	PROPN
admet-390	1	29	:	:	PUNCT
admet-390	1	30	1848	1848	NUM
admet-390	1	31	-	-	SYM
admet-390	1	32	7718	7718	NUM
admet-390	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-390	1	34	review	review	NOUN
admet-390	1	35	expression	expression	NOUN
admet-390	1	36	of	of	ADP
admet-390	1	37	drug	drug	NOUN
admet-390	1	38	transporters	transporter	NOUN
admet-390	1	39	in	in	ADP
admet-390	1	40	the	the	DET
admet-390	1	41	human	human	ADJ
admet-390	1	42	skin	skin	NOUN
admet-390	1	43	:	:	PUNCT
admet-390	1	44	comparison	comparison	NOUN
admet-390	1	45	in	in	ADP
admet-390	1	46	different	different	ADJ
admet-390	1	47	species	specie	NOUN
admet-390	1	48	and	and	CCONJ
admet-390	1	49	models	model	NOUN
admet-390	1	50	and	and	CCONJ
admet-390	1	51	its	its	PRON
admet-390	1	52	implication	implication	NOUN
admet-390	1	53	for	for	ADP
admet-390	1	54	drug	drug	NOUN
admet-390	1	55	development	development	PROPN
admet-390	1	56	hanan	hanan	PROPN
admet-390	1	57	osman	osman	PROPN
admet-390	1	58	-	-	PUNCT
admet-390	1	59	ponchet	ponchet	NOUN
admet-390	1	60	*	*	PROPN
admet-390	1	61	,	,	PUNCT
admet-390	1	62	alexandre	alexandre	PROPN
admet-390	1	63	gaborit	gaborit	PROPN
admet-390	1	64	,	,	PUNCT
admet-390	1	65	jean	jean	PROPN
admet-390	1	66	-	-	PUNCT
admet-390	1	67	michel	michel	PROPN
admet-390	1	68	linget	linget	PROPN
admet-390	1	69	and	and	CCONJ
admet-390	2	1	claire	claire	PROPN
admet-390	2	2	e.	e.	PROPN
admet-390	2	3	wilson	wilson	PROPN
admet-390	2	4	nestlé	nestlé	PROPN
admet-390	2	5	skin	skin	PROPN
admet-390	2	6	health	health	PROPN
admet-390	2	7	,	,	PUNCT
admet-390	2	8	les	les	NOUN
admet-390	2	9	templiers	templier	NOUN
admet-390	2	10	,	,	PUNCT
admet-390	2	11	2400	2400	NUM
admet-390	2	12	route	route	PROPN
admet-390	2	13	des	des	X
admet-390	2	14	colles	colles	PROPN
admet-390	2	15	,	,	PUNCT
admet-390	2	16	bp	bp	PROPN
admet-390	2	17	87	87	NUM
admet-390	2	18	,	,	PUNCT
admet-390	2	19	f-06902	f-06902	PROPN
admet-390	2	20	sophia	sophia	PROPN
admet-390	2	21	-	-	PUNCT
admet-390	2	22	antipolis	antipolis	PROPN
admet-390	2	23	*	*	PUNCT
admet-390	2	24	corresponding	correspond	VERB
admet-390	2	25	author	author	NOUN
admet-390	2	26	:	:	PUNCT
admet-390	2	27	e	e	NOUN
admet-390	2	28	-	-	NOUN
admet-390	2	29	mail	mail	NOUN
admet-390	2	30	:	:	PUNCT
admet-390	2	31	hanan.osman-ponchet@galderma.com	hanan.osman-ponchet@galderma.com	PROPN
admet-390	2	32	;	;	PUNCT
admet-390	2	33	tel	tel	PROPN
admet-390	2	34	.	.	PUNCT
admet-390	2	35	:	:	PUNCT
admet-390	3	1	+33	+33	NUM
admet-390	3	2	-	-	PUNCT
admet-390	3	3	492	492	NUM
admet-390	3	4	-	-	PUNCT
admet-390	3	5	386	386	NUM
admet-390	3	6	-	-	NUM
admet-390	3	7	786	786	NUM
admet-390	3	8	;	;	PUNCT
admet-390	3	9	fax	fax	NOUN
admet-390	3	10	:	:	PUNCT
admet-390	3	11	+33	+33	NUM
admet-390	3	12	-	-	PUNCT
admet-390	3	13	493	493	NUM
admet-390	3	14	-	-	PUNCT
admet-390	3	15	957	957	NUM
admet-390	3	16	-	-	PUNCT
admet-390	3	17	071	071	NUM
admet-390	3	18	received	receive	VERB
admet-390	3	19	:	:	PUNCT
admet-390	3	20	may	may	AUX
admet-390	3	21	02	02	NUM
admet-390	3	22	,	,	PUNCT
admet-390	3	23	2017	2017	NUM
admet-390	3	24	;	;	PUNCT
admet-390	3	25	revised	revise	VERB
admet-390	3	26	:	:	PUNCT
admet-390	3	27	june	june	PROPN
admet-390	3	28	15	15	NUM
admet-390	3	29	,	,	PUNCT
admet-390	3	30	2017	2017	NUM
admet-390	3	31	;	;	PUNCT
admet-390	3	32	published	publish	VERB
admet-390	3	33	:	:	PUNCT
admet-390	3	34	june	june	PROPN
admet-390	3	35	22	22	NUM
admet-390	3	36	,	,	PUNCT
admet-390	3	37	2017	2017	NUM
admet-390	3	38	abstract	abstract	NOUN
admet-390	3	39	it	it	PRON
admet-390	3	40	is	be	AUX
admet-390	3	41	clear	clear	ADJ
admet-390	3	42	that	that	SCONJ
admet-390	3	43	many	many	ADJ
admet-390	3	44	drug	drug	NOUN
admet-390	3	45	transporters	transporter	NOUN
admet-390	3	46	(	(	PUNCT
admet-390	3	47	both	both	CCONJ
admet-390	3	48	abcs	abc	NOUN
admet-390	3	49	and	and	CCONJ
admet-390	3	50	slcs	slcs	NOUN
admet-390	3	51	)	)	PUNCT
admet-390	3	52	are	be	AUX
admet-390	3	53	present	present	ADJ
admet-390	3	54	in	in	ADP
admet-390	3	55	the	the	DET
admet-390	3	56	human	human	ADJ
admet-390	3	57	skin	skin	NOUN
admet-390	3	58	.	.	PUNCT
admet-390	4	1	different	different	ADJ
admet-390	4	2	in	in	ADP
admet-390	4	3	vitro	vitro	X
admet-390	4	4	skin	skin	NOUN
admet-390	4	5	models	model	NOUN
admet-390	4	6	can	can	AUX
admet-390	4	7	be	be	AUX
admet-390	4	8	used	use	VERB
admet-390	4	9	to	to	PART
admet-390	4	10	investigate	investigate	VERB
admet-390	4	11	the	the	DET
admet-390	4	12	role	role	NOUN
admet-390	4	13	of	of	ADP
admet-390	4	14	drug	drug	NOUN
admet-390	4	15	transporters	transporter	NOUN
admet-390	4	16	in	in	ADP
admet-390	4	17	the	the	DET
admet-390	4	18	skin	skin	NOUN
admet-390	4	19	despite	despite	SCONJ
admet-390	4	20	quantitative	quantitative	ADJ
admet-390	4	21	differences	difference	NOUN
admet-390	4	22	in	in	ADP
admet-390	4	23	expression	expression	NOUN
admet-390	4	24	profile	profile	NOUN
admet-390	4	25	across	across	ADP
admet-390	4	26	species	specie	NOUN
admet-390	4	27	.	.	PUNCT
admet-390	5	1	p	p	X
admet-390	5	2	-	-	PUNCT
admet-390	5	3	gp	gp	NOUN
admet-390	5	4	was	be	AUX
admet-390	5	5	shown	show	VERB
admet-390	5	6	to	to	PART
admet-390	5	7	have	have	VERB
admet-390	5	8	an	an	DET
admet-390	5	9	important	important	ADJ
admet-390	5	10	influence	influence	NOUN
admet-390	5	11	on	on	ADP
admet-390	5	12	transdermal	transdermal	ADJ
admet-390	5	13	drug	drug	NOUN
admet-390	5	14	absorption	absorption	NOUN
admet-390	5	15	in	in	ADP
admet-390	5	16	the	the	DET
admet-390	5	17	skin	skin	NOUN
admet-390	5	18	and	and	CCONJ
admet-390	5	19	to	to	PART
admet-390	5	20	function	function	VERB
admet-390	5	21	in	in	ADP
admet-390	5	22	“	"	PUNCT
admet-390	5	23	absorptive	absorptive	ADJ
admet-390	5	24	”	"	PUNCT
admet-390	5	25	transport	transport	NOUN
admet-390	5	26	,	,	PUNCT
admet-390	5	27	carrying	carry	VERB
admet-390	5	28	substrate	substrate	NOUN
admet-390	5	29	drugs	drug	NOUN
admet-390	5	30	from	from	ADP
admet-390	5	31	the	the	DET
admet-390	5	32	skin	skin	NOUN
admet-390	5	33	surface	surface	NOUN
admet-390	5	34	to	to	ADP
admet-390	5	35	the	the	DET
admet-390	5	36	dermis	dermis	NOUN
admet-390	5	37	.	.	PUNCT
admet-390	6	1	this	this	DET
admet-390	6	2	observation	observation	NOUN
admet-390	6	3	might	might	AUX
admet-390	6	4	be	be	AUX
admet-390	6	5	used	use	VERB
admet-390	6	6	to	to	PART
admet-390	6	7	modulate	modulate	VERB
admet-390	6	8	drug	drug	NOUN
admet-390	6	9	distribution	distribution	NOUN
admet-390	6	10	inside	inside	ADP
admet-390	6	11	the	the	DET
admet-390	6	12	skin	skin	NOUN
admet-390	6	13	.	.	PUNCT
admet-390	7	1	if	if	SCONJ
admet-390	7	2	drugs	drug	NOUN
admet-390	7	3	can	can	AUX
admet-390	7	4	be	be	AUX
admet-390	7	5	retained	retain	VERB
admet-390	7	6	in	in	ADP
admet-390	7	7	the	the	DET
admet-390	7	8	epidermis	epidermis	NOUN
admet-390	7	9	compartment	compartment	NOUN
admet-390	7	10	by	by	ADP
admet-390	7	11	inhibition	inhibition	NOUN
admet-390	7	12	of	of	ADP
admet-390	7	13	the	the	DET
admet-390	7	14	transporters	transporter	NOUN
admet-390	7	15	,	,	PUNCT
admet-390	7	16	such	such	ADJ
admet-390	7	17	property	property	NOUN
admet-390	7	18	of	of	ADP
admet-390	7	19	the	the	DET
admet-390	7	20	drug	drug	NOUN
admet-390	7	21	would	would	AUX
admet-390	7	22	be	be	AUX
admet-390	7	23	beneficial	beneficial	ADJ
admet-390	7	24	for	for	ADP
admet-390	7	25	treatment	treatment	NOUN
admet-390	7	26	of	of	ADP
admet-390	7	27	dermatological	dermatological	ADJ
admet-390	7	28	diseases	disease	NOUN
admet-390	7	29	.	.	PUNCT
admet-390	8	1	therefore	therefore	ADV
admet-390	8	2	,	,	PUNCT
admet-390	8	3	it	it	PRON
admet-390	8	4	might	might	AUX
admet-390	8	5	be	be	AUX
admet-390	8	6	feasible	feasible	ADJ
admet-390	8	7	to	to	PART
admet-390	8	8	control	control	VERB
admet-390	8	9	transdermal	transdermal	ADJ
admet-390	8	10	delivery	delivery	NOUN
admet-390	8	11	of	of	ADP
admet-390	8	12	drugs	drug	NOUN
admet-390	8	13	to	to	ADP
admet-390	8	14	specific	specific	ADJ
admet-390	8	15	locations	location	NOUN
admet-390	8	16	in	in	ADP
admet-390	8	17	the	the	DET
admet-390	8	18	skin	skin	NOUN
admet-390	8	19	,	,	PUNCT
admet-390	8	20	by	by	ADP
admet-390	8	21	modulating	modulate	VERB
admet-390	8	22	the	the	DET
admet-390	8	23	function	function	NOUN
admet-390	8	24	of	of	ADP
admet-390	8	25	the	the	DET
admet-390	8	26	transporters	transporter	NOUN
admet-390	8	27	in	in	ADP
admet-390	8	28	the	the	DET
admet-390	8	29	skin	skin	NOUN
admet-390	8	30	.	.	PUNCT
admet-390	9	1	we	we	PRON
admet-390	9	2	are	be	AUX
admet-390	9	3	at	at	ADP
admet-390	9	4	the	the	DET
admet-390	9	5	dawn	dawn	NOUN
admet-390	9	6	of	of	ADP
admet-390	9	7	an	an	DET
admet-390	9	8	exciting	exciting	ADJ
admet-390	9	9	period	period	NOUN
admet-390	9	10	where	where	SCONJ
admet-390	9	11	drug	drug	NOUN
admet-390	9	12	transporters	transporter	NOUN
admet-390	9	13	might	might	AUX
admet-390	9	14	be	be	AUX
admet-390	9	15	novel	novel	ADJ
admet-390	9	16	targets	target	NOUN
admet-390	9	17	for	for	ADP
admet-390	9	18	improvement	improvement	NOUN
admet-390	9	19	of	of	ADP
admet-390	9	20	drug	drug	NOUN
admet-390	9	21	delivery	delivery	NOUN
admet-390	9	22	to	to	ADP
admet-390	9	23	the	the	DET
admet-390	9	24	skin	skin	NOUN
admet-390	9	25	and	and	CCONJ
admet-390	9	26	for	for	ADP
admet-390	9	27	pharmacological	pharmacological	ADJ
admet-390	9	28	intervention	intervention	NOUN
admet-390	9	29	.	.	PUNCT
admet-390	10	1	keywords	keyword	VERB
admet-390	10	2	solute	solute	ADJ
admet-390	10	3	-	-	PUNCT
admet-390	10	4	carrier	carrier	NOUN
admet-390	10	5	transporter	transporter	NOUN
admet-390	10	6	;	;	PUNCT
admet-390	10	7	atp	atp	NOUN
admet-390	10	8	-	-	PUNCT
admet-390	10	9	binding	bind	VERB
admet-390	10	10	cassette	cassette	NOUN
admet-390	10	11	transporter	transporter	NOUN
admet-390	10	12	;	;	PUNCT
admet-390	10	13	skin	skin	NOUN
admet-390	10	14	absorption	absorption	NOUN
admet-390	10	15	introduction	introduction	NOUN
admet-390	10	16	the	the	DET
admet-390	10	17	skin	skin	NOUN
admet-390	10	18	acts	act	VERB
admet-390	10	19	as	as	ADP
admet-390	10	20	an	an	DET
admet-390	10	21	effective	effective	ADJ
admet-390	10	22	barrier	barrier	NOUN
admet-390	10	23	against	against	ADP
admet-390	10	24	intrusion	intrusion	NOUN
admet-390	10	25	from	from	ADP
admet-390	10	26	the	the	DET
admet-390	10	27	outside	outside	NOUN
admet-390	10	28	.	.	PUNCT
admet-390	11	1	the	the	DET
admet-390	11	2	barrier	barrier	NOUN
admet-390	11	3	may	may	AUX
admet-390	11	4	come	come	VERB
admet-390	11	5	in	in	ADP
admet-390	11	6	two	two	NUM
admet-390	11	7	ways	way	NOUN
admet-390	11	8	:	:	PUNCT
admet-390	11	9	a	a	DET
admet-390	11	10	physical	physical	ADJ
admet-390	11	11	one	one	NOUN
admet-390	11	12	mainly	mainly	ADV
admet-390	11	13	through	through	ADP
admet-390	11	14	the	the	DET
admet-390	11	15	stratum	stratum	NOUN
admet-390	11	16	corneum	corneum	NOUN
admet-390	11	17	,	,	PUNCT
admet-390	11	18	and	and	CCONJ
admet-390	11	19	a	a	DET
admet-390	11	20	biochemical	biochemical	ADJ
admet-390	11	21	one	one	NOUN
admet-390	11	22	as	as	SCONJ
admet-390	11	23	it	it	PRON
admet-390	11	24	has	have	AUX
admet-390	11	25	long	long	ADV
admet-390	11	26	been	be	AUX
admet-390	11	27	recognized	recognize	VERB
admet-390	11	28	that	that	SCONJ
admet-390	11	29	drug	drug	NOUN
admet-390	11	30	metabolizing	metabolize	VERB
admet-390	11	31	enzymes	enzyme	NOUN
admet-390	11	32	are	be	AUX
admet-390	11	33	present	present	ADJ
admet-390	11	34	in	in	ADP
admet-390	11	35	the	the	DET
admet-390	11	36	skin	skin	NOUN
admet-390	11	37	:	:	PUNCT
admet-390	11	38	both	both	DET
admet-390	11	39	phase	phase	NOUN
admet-390	11	40	i	i	PRON
admet-390	11	41	and	and	CCONJ
admet-390	11	42	phase	phase	NOUN
admet-390	11	43	ii	ii	PROPN
admet-390	11	44	enzymes	enzyme	NOUN
admet-390	11	45	are	be	AUX
admet-390	11	46	expressed	express	VERB
admet-390	11	47	and	and	CCONJ
admet-390	11	48	skin	skin	NOUN
admet-390	11	49	metabolism	metabolism	NOUN
admet-390	11	50	has	have	AUX
admet-390	11	51	been	be	AUX
admet-390	11	52	the	the	DET
admet-390	11	53	subject	subject	NOUN
admet-390	11	54	of	of	ADP
admet-390	11	55	numerous	numerous	ADJ
admet-390	11	56	reviews	review	NOUN
admet-390	11	57	[	[	X
admet-390	11	58	1	1	NUM
admet-390	11	59	-	-	SYM
admet-390	11	60	3	3	NUM
admet-390	11	61	]	]	PUNCT
admet-390	11	62	mentioning	mention	VERB
admet-390	11	63	specifically	specifically	ADV
admet-390	11	64	the	the	DET
admet-390	11	65	exhaustive	exhaustive	ADJ
admet-390	11	66	one	one	NUM
admet-390	11	67	from	from	ADP
admet-390	11	68	oesch	oesch	PROPN
admet-390	11	69	et	et	PROPN
admet-390	11	70	al	al	PROPN
admet-390	11	71	.	.	PROPN
admet-390	11	72	,	,	PUNCT
admet-390	12	1	[	[	X
admet-390	12	2	4	4	NUM
admet-390	12	3	]	]	PUNCT
admet-390	12	4	.	.	PUNCT
admet-390	13	1	however	however	ADV
admet-390	13	2	,	,	PUNCT
admet-390	13	3	the	the	DET
admet-390	13	4	skin	skin	NOUN
admet-390	13	5	is	be	AUX
admet-390	13	6	far	far	ADV
admet-390	13	7	from	from	ADP
admet-390	13	8	being	be	AUX
admet-390	13	9	a	a	DET
admet-390	13	10	tight	tight	ADJ
admet-390	13	11	barrier	barrier	NOUN
admet-390	13	12	for	for	ADP
admet-390	13	13	small	small	ADJ
admet-390	13	14	lipophilic	lipophilic	ADJ
admet-390	13	15	molecules	molecule	NOUN
admet-390	13	16	as	as	SCONJ
admet-390	13	17	it	it	PRON
admet-390	13	18	is	be	AUX
admet-390	13	19	well	well	ADV
admet-390	13	20	known	know	VERB
admet-390	13	21	that	that	SCONJ
admet-390	13	22	there	there	PRON
admet-390	13	23	is	be	VERB
admet-390	13	24	a	a	DET
admet-390	13	25	myriad	myriad	NOUN
admet-390	13	26	of	of	ADP
admet-390	13	27	applications	application	NOUN
admet-390	13	28	using	use	VERB
admet-390	13	29	the	the	DET
admet-390	13	30	skin	skin	NOUN
admet-390	13	31	as	as	ADP
admet-390	13	32	the	the	DET
admet-390	13	33	port	port	NOUN
admet-390	13	34	of	of	ADP
admet-390	13	35	entry	entry	NOUN
admet-390	13	36	into	into	ADP
admet-390	13	37	the	the	DET
admet-390	13	38	systemic	systemic	ADJ
admet-390	13	39	circulation	circulation	NOUN
admet-390	13	40	in	in	ADP
admet-390	13	41	the	the	DET
admet-390	13	42	form	form	NOUN
admet-390	13	43	of	of	ADP
admet-390	13	44	a	a	DET
admet-390	13	45	patch	patch	NOUN
admet-390	13	46	,	,	PUNCT
admet-390	13	47	lotion	lotion	NOUN
admet-390	13	48	,	,	PUNCT
admet-390	13	49	cream	cream	NOUN
admet-390	13	50	,	,	PUNCT
admet-390	13	51	ointment	ointment	NOUN
admet-390	13	52	…	…	PUNCT
admet-390	13	53	[	[	X
admet-390	13	54	5	5	NUM
admet-390	13	55	]	]	PUNCT
admet-390	13	56	.	.	PUNCT
admet-390	14	1	the	the	DET
admet-390	14	2	permeation	permeation	NOUN
admet-390	14	3	through	through	ADP
admet-390	14	4	the	the	DET
admet-390	14	5	skin	skin	NOUN
admet-390	14	6	of	of	ADP
admet-390	14	7	a	a	DET
admet-390	14	8	toxic	toxic	ADJ
admet-390	14	9	chemical	chemical	NOUN
admet-390	14	10	may	may	AUX
admet-390	14	11	lead	lead	VERB
admet-390	14	12	to	to	ADP
admet-390	14	13	serious	serious	ADJ
admet-390	14	14	adverse	adverse	ADJ
admet-390	14	15	effects	effect	NOUN
admet-390	14	16	as	as	ADP
admet-390	14	17	the	the	DET
admet-390	14	18	most	most	ADV
admet-390	14	19	unfortunate	unfortunate	ADJ
admet-390	14	20	example	example	NOUN
admet-390	14	21	of	of	ADP
admet-390	14	22	hexachlorophene	hexachlorophene	NOUN
admet-390	14	23	poisoning	poisoning	NOUN
admet-390	14	24	in	in	ADP
admet-390	14	25	infants	infant	NOUN
admet-390	14	26	due	due	ADJ
admet-390	14	27	to	to	ADP
admet-390	14	28	contaminated	contaminate	VERB
admet-390	14	29	talc	talc	NOUN
admet-390	14	30	powder	powder	NOUN
admet-390	14	31	has	have	AUX
admet-390	14	32	shown	show	VERB
admet-390	14	33	[	[	PUNCT
admet-390	14	34	6	6	NUM
admet-390	14	35	]	]	PUNCT
admet-390	14	36	.	.	PUNCT
admet-390	15	1	so	so	ADV
admet-390	15	2	now	now	ADV
admet-390	15	3	during	during	ADP
admet-390	15	4	drug	drug	NOUN
admet-390	15	5	development	development	NOUN
admet-390	15	6	of	of	ADP
admet-390	15	7	a	a	DET
admet-390	15	8	new	new	ADJ
admet-390	15	9	dermatological	dermatological	ADJ
admet-390	15	10	product	product	NOUN
admet-390	15	11	it	it	PRON
admet-390	15	12	is	be	AUX
admet-390	15	13	mandatory	mandatory	ADJ
admet-390	15	14	to	to	PART
admet-390	15	15	assess	assess	VERB
admet-390	15	16	the	the	DET
admet-390	15	17	uptake	uptake	NOUN
admet-390	15	18	in	in	ADP
admet-390	15	19	the	the	DET
admet-390	15	20	systemic	systemic	ADJ
admet-390	15	21	circulation	circulation	NOUN
admet-390	15	22	[	[	X
admet-390	15	23	7	7	NUM
admet-390	15	24	]	]	PUNCT
admet-390	15	25	.	.	PUNCT
admet-390	16	1	normal	normal	ADJ
admet-390	16	2	keratinocytes	keratinocyte	NOUN
admet-390	16	3	express	express	VERB
admet-390	16	4	drug	drug	NOUN
admet-390	16	5	metabolizing	metabolize	VERB
admet-390	16	6	enzymes	enzyme	NOUN
admet-390	16	7	[	[	X
admet-390	16	8	8	8	NUM
admet-390	16	9	,	,	PUNCT
admet-390	16	10	9	9	NUM
admet-390	16	11	]	]	PUNCT
admet-390	16	12	but	but	CCONJ
admet-390	16	13	the	the	DET
admet-390	16	14	expression	expression	NOUN
admet-390	16	15	of	of	ADP
admet-390	16	16	these	these	DET
admet-390	16	17	enzymes	enzyme	NOUN
admet-390	16	18	is	be	AUX
admet-390	16	19	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-390	16	20	mailto:hanan.osman-ponchet@galderma.com	mailto:hanan.osman-ponchet@galderma.com	PROPN
admet-390	16	21	h.	h.	PROPN
admet-390	16	22	osman	osman	PROPN
admet-390	16	23	-	-	PUNCT
admet-390	16	24	ponchet	ponchet	NOUN
admet-390	16	25	et	et	PROPN
admet-390	16	26	al	al	PROPN
admet-390	16	27	.	.	PROPN
admet-390	16	28	admet	admet	PROPN
admet-390	16	29	&	&	CCONJ
admet-390	16	30	dmpk	dmpk	PROPN
admet-390	16	31	5(2	5(2	NUM
admet-390	16	32	)	)	PUNCT
admet-390	16	33	(	(	PUNCT
admet-390	16	34	2017	2017	NUM
admet-390	16	35	)	)	PUNCT
admet-390	16	36	75	75	NUM
admet-390	16	37	-	-	SYM
admet-390	16	38	84	84	NUM
admet-390	16	39	76	76	NUM
admet-390	16	40	much	much	ADV
admet-390	16	41	higher	high	ADJ
admet-390	16	42	in	in	ADP
admet-390	16	43	liver	liver	NOUN
admet-390	16	44	and	and	CCONJ
admet-390	16	45	intestine	intestine	NOUN
admet-390	16	46	than	than	ADP
admet-390	16	47	in	in	ADP
admet-390	16	48	skin	skin	NOUN
admet-390	16	49	[	[	X
admet-390	16	50	10	10	NUM
admet-390	16	51	-	-	SYM
admet-390	16	52	13	13	NUM
admet-390	16	53	]	]	PUNCT
admet-390	16	54	.	.	PUNCT
admet-390	17	1	for	for	ADP
admet-390	17	2	most	most	ADJ
admet-390	17	3	drugs	drug	NOUN
admet-390	17	4	the	the	DET
admet-390	17	5	limiting	limit	VERB
admet-390	17	6	factor	factor	NOUN
admet-390	17	7	for	for	ADP
admet-390	17	8	topical	topical	ADJ
admet-390	17	9	bioavailability	bioavailability	NOUN
admet-390	17	10	is	be	AUX
admet-390	17	11	the	the	DET
admet-390	17	12	ability	ability	NOUN
admet-390	17	13	to	to	PART
admet-390	17	14	permeate	permeate	VERB
admet-390	17	15	through	through	ADP
admet-390	17	16	the	the	DET
admet-390	17	17	skin	skin	NOUN
admet-390	17	18	and	and	CCONJ
admet-390	17	19	not	not	PART
admet-390	17	20	the	the	DET
admet-390	17	21	biochemical	biochemical	ADJ
admet-390	17	22	degradation	degradation	NOUN
admet-390	17	23	by	by	ADP
admet-390	17	24	metabolism	metabolism	NOUN
admet-390	17	25	[	[	X
admet-390	17	26	14	14	NUM
admet-390	17	27	,	,	PUNCT
admet-390	17	28	15	15	NUM
admet-390	17	29	]	]	PUNCT
admet-390	17	30	.	.	PUNCT
admet-390	18	1	however	however	ADV
admet-390	18	2	,	,	PUNCT
admet-390	18	3	it	it	PRON
admet-390	18	4	should	should	AUX
admet-390	18	5	be	be	AUX
admet-390	18	6	noted	note	VERB
admet-390	18	7	that	that	SCONJ
admet-390	18	8	for	for	ADP
admet-390	18	9	a	a	DET
admet-390	18	10	compound	compound	NOUN
admet-390	18	11	like	like	ADP
admet-390	18	12	testosterone	testosterone	NOUN
admet-390	18	13	skin	skin	NOUN
admet-390	18	14	metabolism	metabolism	NOUN
admet-390	18	15	reduces	reduce	VERB
admet-390	18	16	sharply	sharply	ADV
admet-390	18	17	the	the	DET
admet-390	18	18	topical	topical	ADJ
admet-390	18	19	bioavailability	bioavailability	NOUN
admet-390	19	1	[	[	X
admet-390	19	2	2	2	NUM
admet-390	19	3	,	,	PUNCT
admet-390	19	4	16	16	NUM
admet-390	19	5	]	]	PUNCT
admet-390	19	6	.	.	PUNCT
admet-390	20	1	transporters	transporter	NOUN
admet-390	20	2	are	be	AUX
admet-390	20	3	by	by	ADP
admet-390	20	4	definition	definition	NOUN
admet-390	20	5	vectors	vector	NOUN
admet-390	20	6	,	,	PUNCT
admet-390	20	7	as	as	SCONJ
admet-390	20	8	they	they	PRON
admet-390	20	9	may	may	AUX
admet-390	20	10	have	have	VERB
admet-390	20	11	an	an	DET
admet-390	20	12	intake	intake	NOUN
admet-390	20	13	or	or	CCONJ
admet-390	20	14	efflux	efflux	ADJ
admet-390	20	15	function	function	NOUN
admet-390	20	16	.	.	PUNCT
admet-390	21	1	but	but	CCONJ
admet-390	21	2	that	that	DET
admet-390	21	3	notion	notion	NOUN
admet-390	21	4	of	of	ADP
admet-390	21	5	influx	influx	NOUN
admet-390	21	6	or	or	CCONJ
admet-390	21	7	efflux	efflux	NOUN
admet-390	21	8	is	be	AUX
admet-390	21	9	a	a	DET
admet-390	21	10	relative	relative	ADJ
admet-390	21	11	one	one	NOUN
admet-390	21	12	as	as	SCONJ
admet-390	21	13	it	it	PRON
admet-390	21	14	depends	depend	VERB
admet-390	21	15	on	on	ADP
admet-390	21	16	the	the	DET
admet-390	21	17	cell	cell	NOUN
admet-390	21	18	or	or	CCONJ
admet-390	21	19	organ	organ	NOUN
admet-390	21	20	we	we	PRON
admet-390	21	21	are	be	AUX
admet-390	21	22	referring	refer	VERB
admet-390	21	23	to	to	ADP
admet-390	21	24	(	(	PUNCT
admet-390	21	25	the	the	DET
admet-390	21	26	efflux	efflux	NOUN
admet-390	21	27	from	from	ADP
admet-390	21	28	one	one	NUM
admet-390	21	29	organ	organ	NOUN
admet-390	21	30	is	be	AUX
admet-390	21	31	the	the	DET
admet-390	21	32	intake	intake	NOUN
admet-390	21	33	of	of	ADP
admet-390	21	34	another	another	DET
admet-390	21	35	one	one	NUM
admet-390	21	36	)	)	PUNCT
admet-390	21	37	.	.	PUNCT
admet-390	22	1	xenobiotic	xenobiotic	ADJ
admet-390	22	2	transporters	transporter	NOUN
admet-390	22	3	are	be	AUX
admet-390	22	4	not	not	PART
admet-390	22	5	specific	specific	ADJ
admet-390	22	6	,	,	PUNCT
admet-390	22	7	they	they	PRON
admet-390	22	8	may	may	AUX
admet-390	22	9	have	have	VERB
admet-390	22	10	several	several	ADJ
admet-390	22	11	(	(	PUNCT
admet-390	22	12	or	or	CCONJ
admet-390	22	13	many	many	ADJ
admet-390	22	14	)	)	PUNCT
admet-390	22	15	substrates	substrate	NOUN
admet-390	22	16	and	and	CCONJ
admet-390	22	17	as	as	ADP
admet-390	22	18	many	many	ADJ
admet-390	22	19	inhibitors	inhibitor	NOUN
admet-390	22	20	(	(	PUNCT
admet-390	22	21	albeit	albeit	SCONJ
admet-390	22	22	with	with	ADP
admet-390	22	23	a	a	DET
admet-390	22	24	different	different	ADJ
admet-390	22	25	affinity	affinity	NOUN
admet-390	22	26	)	)	PUNCT
admet-390	22	27	.	.	PUNCT
admet-390	23	1	drug	drug	NOUN
admet-390	23	2	transporters	transporter	NOUN
admet-390	23	3	in	in	ADP
admet-390	23	4	the	the	DET
admet-390	23	5	skin	skin	NOUN
admet-390	23	6	belonging	belong	VERB
admet-390	23	7	to	to	ADP
admet-390	23	8	both	both	CCONJ
admet-390	23	9	the	the	DET
admet-390	23	10	atp	atp	NOUN
admet-390	23	11	-	-	PUNCT
admet-390	23	12	binding	bind	VERB
admet-390	23	13	cassette	cassette	NOUN
admet-390	23	14	(	(	PUNCT
admet-390	23	15	abc	abc	PROPN
admet-390	23	16	)	)	PUNCT
admet-390	24	1	[	[	X
admet-390	24	2	17	17	NUM
admet-390	24	3	-	-	SYM
admet-390	24	4	23	23	NUM
admet-390	24	5	]	]	PUNCT
admet-390	24	6	and	and	CCONJ
admet-390	24	7	solute	solute	ADJ
admet-390	24	8	carrier	carrier	NOUN
admet-390	24	9	(	(	PUNCT
admet-390	24	10	slc	slc	PROPN
admet-390	24	11	)	)	PUNCT
admet-390	24	12	families	family	NOUN
admet-390	24	13	[	[	X
admet-390	24	14	17	17	NUM
admet-390	24	15	,	,	PUNCT
admet-390	24	16	23	23	NUM
admet-390	24	17	-	-	SYM
admet-390	24	18	25	25	NUM
admet-390	24	19	]	]	PUNCT
admet-390	24	20	have	have	AUX
admet-390	24	21	been	be	AUX
admet-390	24	22	identified	identify	VERB
admet-390	24	23	in	in	ADP
admet-390	24	24	man	man	NOUN
admet-390	24	25	and	and	CCONJ
admet-390	24	26	other	other	ADJ
admet-390	24	27	animal	animal	NOUN
admet-390	24	28	species	specie	NOUN
admet-390	24	29	but	but	CCONJ
admet-390	24	30	our	our	PRON
admet-390	24	31	knowledge	knowledge	NOUN
admet-390	24	32	of	of	ADP
admet-390	24	33	these	these	DET
admet-390	24	34	transporters	transporter	NOUN
admet-390	24	35	is	be	AUX
admet-390	24	36	just	just	ADV
admet-390	24	37	at	at	ADP
admet-390	24	38	the	the	DET
admet-390	24	39	beginning	beginning	NOUN
admet-390	24	40	and	and	CCONJ
admet-390	24	41	is	be	AUX
admet-390	24	42	not	not	PART
admet-390	24	43	as	as	ADV
admet-390	24	44	advanced	advanced	ADJ
admet-390	24	45	as	as	ADP
admet-390	24	46	for	for	ADP
admet-390	24	47	drug	drug	NOUN
admet-390	24	48	metabolizing	metabolize	VERB
admet-390	24	49	enzymes	enzyme	NOUN
admet-390	24	50	.	.	PUNCT
admet-390	25	1	we	we	PRON
admet-390	25	2	would	would	AUX
admet-390	25	3	like	like	VERB
admet-390	25	4	to	to	PART
admet-390	25	5	review	review	VERB
admet-390	25	6	in	in	ADP
admet-390	25	7	the	the	DET
admet-390	25	8	present	present	ADJ
admet-390	25	9	paper	paper	NOUN
admet-390	25	10	our	our	PRON
admet-390	25	11	knowledge	knowledge	NOUN
admet-390	25	12	on	on	ADP
admet-390	25	13	drug	drug	NOUN
admet-390	25	14	transporters	transporter	NOUN
admet-390	25	15	in	in	ADP
admet-390	25	16	the	the	DET
admet-390	25	17	skin	skin	NOUN
admet-390	25	18	not	not	PART
admet-390	25	19	by	by	ADP
admet-390	25	20	giving	give	VERB
admet-390	25	21	an	an	DET
admet-390	25	22	exhaustive	exhaustive	ADJ
admet-390	25	23	list	list	NOUN
admet-390	25	24	of	of	ADP
admet-390	25	25	everything	everything	PRON
admet-390	25	26	that	that	PRON
admet-390	25	27	has	have	AUX
admet-390	25	28	been	be	AUX
admet-390	25	29	done	do	VERB
admet-390	25	30	but	but	CCONJ
admet-390	25	31	on	on	ADP
admet-390	25	32	focusing	focus	VERB
admet-390	25	33	on	on	ADP
admet-390	25	34	what	what	PRON
admet-390	25	35	is	be	AUX
admet-390	25	36	known	know	VERB
admet-390	25	37	and	and	CCONJ
admet-390	25	38	not	not	PART
admet-390	25	39	known	know	VERB
admet-390	25	40	on	on	ADP
admet-390	25	41	expression	expression	NOUN
admet-390	25	42	and	and	CCONJ
admet-390	25	43	function	function	NOUN
admet-390	25	44	of	of	ADP
admet-390	25	45	these	these	DET
admet-390	25	46	transporters	transporter	NOUN
admet-390	25	47	in	in	ADP
admet-390	25	48	the	the	DET
admet-390	25	49	perspective	perspective	NOUN
admet-390	25	50	of	of	ADP
admet-390	25	51	drug	drug	NOUN
admet-390	25	52	development	development	NOUN
admet-390	25	53	.	.	PUNCT
admet-390	26	1	we	we	PRON
admet-390	26	2	will	will	AUX
admet-390	26	3	discuss	discuss	VERB
admet-390	26	4	the	the	DET
admet-390	26	5	potential	potential	ADJ
admet-390	26	6	implication	implication	NOUN
admet-390	26	7	of	of	ADP
admet-390	26	8	the	the	DET
admet-390	26	9	presence	presence	NOUN
admet-390	26	10	of	of	ADP
admet-390	26	11	these	these	DET
admet-390	26	12	transporters	transporter	NOUN
admet-390	26	13	on	on	ADP
admet-390	26	14	drug	drug	NOUN
admet-390	26	15	development	development	NOUN
admet-390	26	16	both	both	PRON
admet-390	26	17	on	on	ADP
admet-390	26	18	the	the	DET
admet-390	26	19	aspect	aspect	NOUN
admet-390	26	20	of	of	ADP
admet-390	26	21	topical	topical	ADJ
admet-390	26	22	absorption	absorption	NOUN
admet-390	26	23	and	and	CCONJ
admet-390	26	24	of	of	ADP
admet-390	26	25	being	be	AUX
admet-390	26	26	the	the	DET
admet-390	26	27	target	target	NOUN
admet-390	26	28	of	of	ADP
admet-390	26	29	pharmacological	pharmacological	ADJ
admet-390	26	30	intervention	intervention	NOUN
admet-390	26	31	.	.	PUNCT
admet-390	27	1	skin	skin	NOUN
admet-390	27	2	models	model	NOUN
admet-390	27	3	different	different	ADJ
admet-390	27	4	skin	skin	NOUN
admet-390	27	5	models	model	NOUN
admet-390	27	6	can	can	AUX
admet-390	27	7	be	be	AUX
admet-390	27	8	used	use	VERB
admet-390	27	9	to	to	PART
admet-390	27	10	characterize	characterize	VERB
admet-390	27	11	drug	drug	NOUN
admet-390	27	12	transporters	transporter	NOUN
admet-390	27	13	in	in	ADP
admet-390	27	14	the	the	DET
admet-390	27	15	skin	skin	NOUN
admet-390	27	16	,	,	PUNCT
admet-390	27	17	among	among	ADP
admet-390	27	18	them	they	PRON
admet-390	27	19	,	,	PUNCT
admet-390	27	20	skin	skin	NOUN
admet-390	27	21	organ	organ	NOUN
admet-390	27	22	-	-	PUNCT
admet-390	27	23	culture	culture	NOUN
admet-390	27	24	,	,	PUNCT
admet-390	27	25	3d	3d	NUM
admet-390	27	26	skin	skin	NOUN
admet-390	27	27	microtissue	microtissue	NOUN
admet-390	27	28	and	and	CCONJ
admet-390	27	29	3d	3d	NUM
admet-390	27	30	reconstructed	reconstruct	VERB
admet-390	27	31	epidermis	epidermis	NOUN
admet-390	27	32	models	model	NOUN
admet-390	27	33	.	.	PUNCT
admet-390	28	1	skin	skin	NOUN
admet-390	28	2	organ	organ	NOUN
admet-390	28	3	-	-	PUNCT
admet-390	28	4	culture	culture	NOUN
admet-390	28	5	model	model	NOUN
admet-390	28	6	skin	skin	NOUN
admet-390	28	7	organ	organ	NOUN
admet-390	28	8	-	-	PUNCT
admet-390	28	9	culture	culture	NOUN
admet-390	28	10	model	model	NOUN
admet-390	28	11	was	be	AUX
admet-390	28	12	previously	previously	ADV
admet-390	28	13	described	describe	VERB
admet-390	28	14	[	[	X
admet-390	28	15	20	20	NUM
admet-390	28	16	,	,	PUNCT
admet-390	28	17	24	24	NUM
admet-390	28	18	]	]	PUNCT
admet-390	28	19	.	.	PUNCT
admet-390	29	1	briefly	briefly	NOUN
admet-390	29	2	,	,	PUNCT
admet-390	29	3	biopsies	biopsy	NOUN
admet-390	29	4	of	of	ADP
admet-390	29	5	fresh	fresh	ADJ
admet-390	29	6	human	human	ADJ
admet-390	29	7	skin	skin	NOUN
admet-390	29	8	samples	sample	NOUN
admet-390	29	9	excised	excise	VERB
admet-390	29	10	during	during	ADP
admet-390	29	11	cosmetic	cosmetic	ADJ
admet-390	29	12	surgery	surgery	NOUN
admet-390	29	13	are	be	AUX
admet-390	29	14	collected	collect	VERB
admet-390	29	15	and	and	CCONJ
admet-390	29	16	cultivated	cultivate	VERB
admet-390	29	17	in	in	ADP
admet-390	29	18	chemically	chemically	ADV
admet-390	29	19	defined	define	VERB
admet-390	29	20	skin	skin	NOUN
admet-390	29	21	culture	culture	NOUN
admet-390	29	22	medium	medium	NOUN
admet-390	29	23	.	.	PUNCT
admet-390	30	1	3d	3d	PROPN
admet-390	30	2	human	human	PROPN
admet-390	30	3	skin	skin	PROPN
admet-390	30	4	micro	micro	NOUN
admet-390	30	5	-	-	ADJ
admet-390	30	6	tissue	tissue	ADJ
admet-390	30	7	model	model	NOUN
admet-390	30	8	3d	3d	PROPN
admet-390	30	9	human	human	PROPN
admet-390	30	10	skin	skin	PROPN
admet-390	30	11	micro	micro	NOUN
admet-390	30	12	-	-	NOUN
admet-390	30	13	tissue	tissue	NOUN
admet-390	30	14	is	be	AUX
admet-390	30	15	a	a	DET
admet-390	30	16	spherical	spherical	ADJ
admet-390	30	17	in	in	ADP
admet-390	30	18	vitro	vitro	X
admet-390	30	19	skin	skin	NOUN
admet-390	30	20	model	model	NOUN
admet-390	30	21	consisting	consist	VERB
admet-390	30	22	of	of	ADP
admet-390	30	23	spherical	spherical	ADJ
admet-390	30	24	skin	skin	NOUN
admet-390	30	25	equivalent	equivalent	ADJ
admet-390	30	26	(	(	PUNCT
admet-390	30	27	up	up	ADP
admet-390	30	28	to	to	PART
admet-390	30	29	500	500	NUM
admet-390	30	30	μm	μm	NUM
admet-390	30	31	diameter	diameter	NOUN
admet-390	30	32	)	)	PUNCT
admet-390	30	33	containing	contain	VERB
admet-390	30	34	fibroblasts	fibroblast	NOUN
admet-390	30	35	(	(	PUNCT
admet-390	30	36	dermal	dermal	ADJ
admet-390	30	37	core	core	NOUN
admet-390	30	38	-	-	PUNCT
admet-390	30	39	like	like	ADJ
admet-390	30	40	)	)	PUNCT
admet-390	30	41	surrounded	surround	VERB
admet-390	30	42	by	by	ADP
admet-390	30	43	keratinocytes	keratinocyte	NOUN
admet-390	30	44	(	(	PUNCT
admet-390	30	45	epidermis	epidermis	NOUN
admet-390	30	46	-	-	PUNCT
admet-390	30	47	like	like	ADJ
admet-390	30	48	)	)	PUNCT
admet-390	30	49	(	(	PUNCT
admet-390	30	50	figure	figure	NOUN
admet-390	30	51	1a	1a	NOUN
admet-390	30	52	)	)	PUNCT
admet-390	30	53	.	.	PUNCT
admet-390	31	1	this	this	PRON
admet-390	31	2	in	in	ADP
admet-390	31	3	vitro	vitro	X
admet-390	31	4	model	model	NOUN
admet-390	31	5	provided	provide	VERB
admet-390	31	6	in	in	ADP
admet-390	31	7	a	a	DET
admet-390	31	8	96	96	NUM
admet-390	31	9	-	-	PUNCT
admet-390	31	10	well	well	NOUN
admet-390	31	11	format	format	NOUN
admet-390	31	12	actually	actually	ADV
admet-390	31	13	available	available	ADJ
admet-390	31	14	as	as	SCONJ
admet-390	31	15	beta	beta	NOUN
admet-390	31	16	-	-	PUNCT
admet-390	31	17	testing	testing	NOUN
admet-390	31	18	for	for	ADP
admet-390	31	19	screening	screen	VERB
admet-390	31	20	in	in	ADP
admet-390	31	21	dermatology	dermatology	NOUN
admet-390	31	22	is	be	AUX
admet-390	31	23	provided	provide	VERB
admet-390	31	24	by	by	ADP
admet-390	31	25	insphero	insphero	NOUN
admet-390	31	26	(	(	PUNCT
admet-390	31	27	switzerland	switzerland	PROPN
admet-390	31	28	)	)	PUNCT
admet-390	31	29	.	.	PUNCT
admet-390	32	1	3d	3d	PROPN
admet-390	32	2	reconstructed	reconstruct	VERB
admet-390	32	3	human	human	ADJ
admet-390	32	4	epidermis	epidermis	NOUN
admet-390	32	5	model	model	NOUN
admet-390	32	6	reconstructed	reconstruct	VERB
admet-390	32	7	human	human	ADJ
admet-390	32	8	epidermis	epidermis	NOUN
admet-390	32	9	(	(	PUNCT
admet-390	32	10	rhe	rhe	NOUN
admet-390	32	11	)	)	PUNCT
admet-390	32	12	consists	consist	VERB
admet-390	32	13	of	of	ADP
admet-390	32	14	an	an	DET
admet-390	32	15	air	air	NOUN
admet-390	32	16	-	-	PUNCT
admet-390	32	17	lifted	lift	VERB
admet-390	32	18	,	,	PUNCT
admet-390	32	19	living	living	NOUN
admet-390	32	20	,	,	PUNCT
admet-390	32	21	multi	multi	ADJ
admet-390	32	22	-	-	ADJ
admet-390	32	23	layered	layered	ADJ
admet-390	32	24	tissue	tissue	NOUN
admet-390	32	25	construct	construct	NOUN
admet-390	32	26	produced	produce	VERB
admet-390	32	27	in	in	ADP
admet-390	32	28	polycarbonate	polycarbonate	NOUN
admet-390	32	29	inserts	insert	NOUN
admet-390	32	30	in	in	ADP
admet-390	32	31	serum	serum	NOUN
admet-390	32	32	-	-	PUNCT
admet-390	32	33	free	free	ADJ
admet-390	32	34	and	and	CCONJ
admet-390	32	35	chemically	chemically	ADV
admet-390	32	36	defined	define	VERB
admet-390	32	37	medium	medium	NOUN
admet-390	32	38	,	,	PUNCT
admet-390	32	39	featuring	feature	VERB
admet-390	32	40	normal	normal	ADJ
admet-390	32	41	ultrastructure	ultrastructure	NOUN
admet-390	32	42	and	and	CCONJ
admet-390	32	43	functionality	functionality	NOUN
admet-390	32	44	similar	similar	ADJ
admet-390	32	45	to	to	ADP
admet-390	32	46	human	human	ADJ
admet-390	32	47	tissue	tissue	NOUN
admet-390	32	48	in	in	ADP
admet-390	32	49	vivo	vivo	NOUN
admet-390	32	50	(	(	PUNCT
admet-390	32	51	figure	figure	NOUN
admet-390	32	52	1b	1b	NUM
admet-390	32	53	)	)	PUNCT
admet-390	32	54	.	.	PUNCT
admet-390	33	1	the	the	DET
admet-390	33	2	rhe	rhe	PROPN
admet-390	33	3	model	model	NOUN
admet-390	33	4	episkin	episkin	X
admet-390	33	5	(	(	PUNCT
admet-390	33	6	france	france	PROPN
admet-390	33	7	)	)	PUNCT
admet-390	33	8	is	be	AUX
admet-390	33	9	generated	generate	VERB
admet-390	33	10	from	from	ADP
admet-390	33	11	primary	primary	ADJ
admet-390	33	12	normal	normal	ADJ
admet-390	33	13	human	human	ADJ
admet-390	33	14	keratinocytes	keratinocyte	NOUN
admet-390	33	15	.	.	PUNCT
admet-390	34	1	this	this	DET
admet-390	34	2	model	model	NOUN
admet-390	34	3	most	most	ADV
admet-390	34	4	closely	closely	ADV
admet-390	34	5	mimics	mimic	VERB
admet-390	34	6	normal	normal	ADJ
admet-390	34	7	skin	skin	NOUN
admet-390	34	8	,	,	PUNCT
admet-390	34	9	allowing	allow	VERB
admet-390	34	10	the	the	DET
admet-390	34	11	topical	topical	ADJ
admet-390	34	12	application	application	NOUN
admet-390	34	13	of	of	ADP
admet-390	34	14	a	a	DET
admet-390	34	15	great	great	ADJ
admet-390	34	16	variety	variety	NOUN
admet-390	34	17	of	of	ADP
admet-390	34	18	products	product	NOUN
admet-390	34	19	,	,	PUNCT
admet-390	34	20	solid	solid	ADJ
admet-390	34	21	,	,	PUNCT
admet-390	34	22	liquid	liquid	NOUN
admet-390	34	23	,	,	PUNCT
admet-390	34	24	gel	gel	NOUN
admet-390	34	25	,	,	PUNCT
admet-390	34	26	cream	cream	NOUN
admet-390	34	27	…	…	PUNCT
admet-390	34	28	however	however	ADV
admet-390	34	29	,	,	PUNCT
admet-390	34	30	this	this	DET
admet-390	34	31	skin	skin	NOUN
admet-390	34	32	model	model	NOUN
admet-390	34	33	contains	contain	VERB
admet-390	34	34	only	only	ADV
admet-390	34	35	one	one	NUM
admet-390	34	36	cell	cell	NOUN
admet-390	34	37	type	type	NOUN
admet-390	34	38	,	,	PUNCT
admet-390	34	39	lacks	lack	VERB
admet-390	34	40	skin	skin	NOUN
admet-390	34	41	appendages	appendage	NOUN
admet-390	34	42	,	,	PUNCT
admet-390	34	43	and	and	CCONJ
admet-390	34	44	therefore	therefore	ADV
admet-390	34	45	is	be	AUX
admet-390	34	46	insufficient	insufficient	ADJ
admet-390	34	47	to	to	PART
admet-390	34	48	adequately	adequately	ADV
admet-390	34	49	mimic	mimic	VERB
admet-390	34	50	the	the	DET
admet-390	34	51	complexity	complexity	NOUN
admet-390	34	52	of	of	ADP
admet-390	34	53	human	human	ADJ
admet-390	34	54	skin	skin	NOUN
admet-390	34	55	.	.	PUNCT
admet-390	35	1	admet	admet	PROPN
admet-390	35	2	&	&	CCONJ
admet-390	35	3	dmpk	dmpk	PROPN
admet-390	35	4	5(2	5(2	NUM
admet-390	35	5	)	)	PUNCT
admet-390	35	6	(	(	PUNCT
admet-390	35	7	2017	2017	NUM
admet-390	35	8	)	)	PUNCT
admet-390	35	9	75	75	NUM
admet-390	35	10	-	-	SYM
admet-390	35	11	84	84	NUM
admet-390	35	12	expression	expression	NOUN
admet-390	35	13	of	of	ADP
admet-390	35	14	drug	drug	NOUN
admet-390	35	15	transporters	transporter	NOUN
admet-390	35	16	in	in	ADP
admet-390	35	17	the	the	DET
admet-390	35	18	human	human	ADJ
admet-390	35	19	skin	skin	NOUN
admet-390	35	20	doi	doi	NOUN
admet-390	35	21	:	:	PUNCT
admet-390	35	22	10.5599	10.5599	NUM
admet-390	35	23	/	/	SYM
admet-390	35	24	admet.5.2.390	admet.5.2.390	PROPN
admet-390	35	25	77	77	NUM
admet-390	35	26	figure	figure	NOUN
admet-390	35	27	1	1	NUM
admet-390	35	28	.	.	X
admet-390	35	29	3d	3d	NOUN
admet-390	35	30	in	in	ADP
admet-390	35	31	vitro	vitro	X
admet-390	35	32	skin	skin	NOUN
admet-390	35	33	models	model	NOUN
admet-390	35	34	.	.	PUNCT
admet-390	36	1	(	(	PUNCT
admet-390	36	2	a	a	X
admet-390	36	3	)	)	PUNCT
admet-390	36	4	3d	3d	PROPN
admet-390	36	5	human	human	ADJ
admet-390	36	6	skin	skin	NOUN
admet-390	36	7	microtissue	microtissue	NOUN
admet-390	36	8	.	.	PUNCT
admet-390	37	1	(	(	PUNCT
admet-390	37	2	b	b	X
admet-390	37	3	)	)	PUNCT
admet-390	37	4	3d	3d	NOUN
admet-390	37	5	reconstructed	reconstruct	VERB
admet-390	37	6	human	human	ADJ
admet-390	37	7	epidermis	epidermis	NOUN
admet-390	37	8	.	.	PUNCT
admet-390	38	1	gene	gene	NOUN
admet-390	38	2	expression	expression	NOUN
admet-390	38	3	of	of	ADP
admet-390	38	4	transporters	transporter	NOUN
admet-390	38	5	in	in	ADP
admet-390	38	6	different	different	ADJ
admet-390	38	7	species	species	NOUN
admet-390	38	8	expression	expression	NOUN
admet-390	38	9	in	in	ADP
admet-390	38	10	human	human	ADJ
admet-390	38	11	skin	skin	NOUN
admet-390	38	12	several	several	ADJ
admet-390	38	13	studies	study	NOUN
admet-390	38	14	have	have	AUX
admet-390	38	15	reported	report	VERB
admet-390	38	16	the	the	DET
admet-390	38	17	expression	expression	NOUN
admet-390	38	18	of	of	ADP
admet-390	38	19	transporters	transporter	NOUN
admet-390	38	20	in	in	ADP
admet-390	38	21	human	human	ADJ
admet-390	38	22	skin	skin	NOUN
admet-390	38	23	[	[	X
admet-390	38	24	17	17	NUM
admet-390	38	25	-	-	SYM
admet-390	38	26	25	25	NUM
admet-390	38	27	]	]	PUNCT
admet-390	38	28	.	.	PUNCT
admet-390	39	1	their	their	PRON
admet-390	39	2	objectives	objective	NOUN
admet-390	39	3	and	and	CCONJ
admet-390	39	4	methods	method	NOUN
admet-390	39	5	were	be	AUX
admet-390	39	6	not	not	PART
admet-390	39	7	identical	identical	ADJ
admet-390	39	8	,	,	PUNCT
admet-390	39	9	but	but	CCONJ
admet-390	39	10	their	their	PRON
admet-390	39	11	results	result	NOUN
admet-390	39	12	which	which	PRON
admet-390	39	13	can	can	AUX
admet-390	39	14	not	not	PART
admet-390	39	15	be	be	AUX
admet-390	39	16	exactly	exactly	ADV
admet-390	39	17	compared	compare	VERB
admet-390	39	18	,	,	PUNCT
admet-390	39	19	show	show	VERB
admet-390	39	20	clearly	clearly	ADV
admet-390	39	21	the	the	DET
admet-390	39	22	presence	presence	NOUN
admet-390	39	23	of	of	ADP
admet-390	39	24	abc	abc	PROPN
admet-390	39	25	and	and	CCONJ
admet-390	39	26	slc	slc	PROPN
admet-390	39	27	transporters	transporter	NOUN
admet-390	39	28	in	in	ADP
admet-390	39	29	human	human	ADJ
admet-390	39	30	skin	skin	NOUN
admet-390	39	31	.	.	PUNCT
admet-390	40	1	the	the	DET
admet-390	40	2	semi	semi	ADJ
admet-390	40	3	-	-	ADJ
admet-390	40	4	quantitative	quantitative	ADJ
admet-390	40	5	expression	expression	NOUN
admet-390	40	6	of	of	ADP
admet-390	40	7	human	human	ADJ
admet-390	40	8	abc	abc	PROPN
admet-390	40	9	transporters	transporter	NOUN
admet-390	40	10	in	in	ADP
admet-390	40	11	skin	skin	NOUN
admet-390	40	12	has	have	AUX
admet-390	40	13	been	be	AUX
admet-390	40	14	reported	report	VERB
admet-390	40	15	[	[	X
admet-390	40	16	21	21	NUM
admet-390	40	17	]	]	PUNCT
admet-390	40	18	,	,	PUNCT
admet-390	40	19	and	and	CCONJ
admet-390	40	20	in	in	ADP
admet-390	40	21	this	this	DET
admet-390	40	22	study	study	NOUN
admet-390	40	23	most	most	ADJ
admet-390	40	24	of	of	ADP
admet-390	40	25	the	the	DET
admet-390	40	26	abca	abca	NOUN
admet-390	40	27	,	,	PUNCT
admet-390	40	28	abcb	abcb	NOUN
admet-390	40	29	,	,	PUNCT
admet-390	40	30	abcc	abcc	PROPN
admet-390	40	31	,	,	PUNCT
admet-390	40	32	abcd	abcd	PROPN
admet-390	40	33	,	,	PUNCT
admet-390	40	34	abce	abce	PROPN
admet-390	40	35	,	,	PUNCT
admet-390	40	36	abcf	abcf	NOUN
admet-390	40	37	,	,	PUNCT
admet-390	40	38	and	and	CCONJ
admet-390	40	39	abcg	abcg	ADP
admet-390	40	40	family	family	NOUN
admet-390	40	41	members	member	NOUN
admet-390	40	42	were	be	AUX
admet-390	40	43	found	find	VERB
admet-390	40	44	to	to	PART
admet-390	40	45	be	be	AUX
admet-390	40	46	slightly	slightly	ADV
admet-390	40	47	(	(	PUNCT
admet-390	40	48	for	for	ADP
admet-390	40	49	abcg	abcg	NOUN
admet-390	40	50	)	)	PUNCT
admet-390	40	51	to	to	AUX
admet-390	40	52	moderately	moderately	ADV
admet-390	40	53	-	-	PUNCT
admet-390	40	54	highly	highly	ADV
admet-390	40	55	expressed	express	VERB
admet-390	40	56	for	for	ADP
admet-390	40	57	the	the	DET
admet-390	40	58	other	other	ADJ
admet-390	40	59	family	family	NOUN
admet-390	40	60	members	member	NOUN
admet-390	40	61	.	.	PUNCT
admet-390	41	1	it	it	PRON
admet-390	41	2	should	should	AUX
admet-390	41	3	be	be	AUX
admet-390	41	4	noted	note	VERB
admet-390	41	5	that	that	SCONJ
admet-390	41	6	in	in	ADP
admet-390	41	7	this	this	DET
admet-390	41	8	study	study	NOUN
admet-390	41	9	a	a	DET
admet-390	41	10	significant	significant	ADJ
admet-390	41	11	inter	inter	ADJ
admet-390	41	12	-	-	ADJ
admet-390	41	13	individual	individual	ADJ
admet-390	41	14	variability	variability	NOUN
admet-390	41	15	in	in	ADP
admet-390	41	16	the	the	DET
admet-390	41	17	expression	expression	NOUN
admet-390	41	18	was	be	AUX
admet-390	41	19	observed	observe	VERB
admet-390	41	20	as	as	SCONJ
admet-390	41	21	no	no	DET
admet-390	41	22	expression	expression	NOUN
admet-390	41	23	was	be	AUX
admet-390	41	24	detected	detect	VERB
admet-390	41	25	in	in	ADP
admet-390	41	26	some	some	DET
admet-390	41	27	human	human	ADJ
admet-390	41	28	samples	sample	NOUN
admet-390	41	29	:	:	PUNCT
admet-390	41	30	abca5	abca5	NOUN
admet-390	41	31	and	and	CCONJ
admet-390	41	32	abcf1	abcf1	NOUN
admet-390	41	33	being	be	AUX
admet-390	41	34	the	the	DET
admet-390	41	35	exception	exception	NOUN
admet-390	41	36	.	.	PUNCT
admet-390	42	1	in	in	ADP
admet-390	42	2	another	another	DET
admet-390	42	3	study	study	NOUN
admet-390	42	4	[	[	X
admet-390	42	5	20	20	NUM
admet-390	42	6	]	]	PUNCT
admet-390	42	7	mrna	mrna	NOUN
admet-390	42	8	expression	expression	NOUN
admet-390	42	9	of	of	ADP
admet-390	42	10	abcb1	abcb1	PROPN
admet-390	42	11	,	,	PUNCT
admet-390	42	12	abcc1	abcc1	PROPN
admet-390	42	13	,	,	PUNCT
admet-390	42	14	abcc2	abcc2	PROPN
admet-390	42	15	and	and	CCONJ
admet-390	42	16	abcg2	abcg2	NOUN
admet-390	42	17	was	be	AUX
admet-390	42	18	measured	measure	VERB
admet-390	42	19	in	in	ADP
admet-390	42	20	human	human	ADJ
admet-390	42	21	skin	skin	NOUN
admet-390	42	22	organ	organ	NOUN
admet-390	42	23	-	-	PUNCT
admet-390	42	24	culture	culture	NOUN
admet-390	42	25	using	use	VERB
admet-390	42	26	rt	rt	NOUN
admet-390	42	27	-	-	PUNCT
admet-390	42	28	pcr	pcr	NOUN
admet-390	42	29	.	.	PUNCT
admet-390	43	1	it	it	PRON
admet-390	43	2	was	be	AUX
admet-390	43	3	found	find	VERB
admet-390	43	4	that	that	SCONJ
admet-390	43	5	expression	expression	NOUN
admet-390	43	6	of	of	ADP
admet-390	43	7	abcc1	abcc1	PROPN
admet-390	43	8	(	(	PUNCT
admet-390	43	9	mrp1	mrp1	PROPN
admet-390	43	10	)	)	PUNCT
admet-390	43	11	was	be	AUX
admet-390	43	12	very	very	ADV
admet-390	43	13	high	high	ADJ
admet-390	43	14	compared	compare	VERB
admet-390	43	15	to	to	ADP
admet-390	43	16	those	those	PRON
admet-390	43	17	of	of	ADP
admet-390	43	18	abcb1	abcb1	NOUN
admet-390	43	19	,	,	PUNCT
admet-390	43	20	abcc2	abcc2	NOUN
admet-390	43	21	,	,	PUNCT
admet-390	43	22	and	and	CCONJ
admet-390	43	23	abcg2	abcg2	PUNCT
admet-390	44	1	[	[	X
admet-390	44	2	20	20	NUM
admet-390	44	3	]	]	PUNCT
admet-390	44	4	.	.	PUNCT
admet-390	45	1	comparatively	comparatively	ADV
admet-390	45	2	to	to	ADP
admet-390	45	3	the	the	DET
admet-390	45	4	liver	liver	NOUN
admet-390	45	5	or	or	CCONJ
admet-390	45	6	kidney	kidney	VERB
admet-390	45	7	the	the	DET
admet-390	45	8	expression	expression	NOUN
admet-390	45	9	of	of	ADP
admet-390	45	10	abc	abc	PROPN
admet-390	45	11	transporters	transporter	NOUN
admet-390	45	12	in	in	ADP
admet-390	45	13	human	human	ADJ
admet-390	45	14	skin	skin	NOUN
admet-390	45	15	is	be	AUX
admet-390	45	16	usually	usually	ADV
admet-390	45	17	lower	low	ADJ
admet-390	45	18	but	but	CCONJ
admet-390	45	19	we	we	PRON
admet-390	45	20	found	find	VERB
admet-390	45	21	that	that	SCONJ
admet-390	45	22	for	for	ADP
admet-390	45	23	abcc1	abcc1	NOUN
admet-390	45	24	the	the	DET
admet-390	45	25	reverse	reverse	NOUN
admet-390	45	26	is	be	AUX
admet-390	45	27	true	true	ADJ
admet-390	45	28	as	as	SCONJ
admet-390	45	29	there	there	PRON
admet-390	45	30	is	be	VERB
admet-390	45	31	more	more	ADJ
admet-390	45	32	than	than	ADP
admet-390	45	33	30	30	NUM
admet-390	45	34	fold	fold	ADJ
admet-390	45	35	higher	high	ADJ
admet-390	45	36	expression	expression	NOUN
admet-390	45	37	in	in	ADP
admet-390	45	38	human	human	ADJ
admet-390	45	39	skin	skin	NOUN
admet-390	45	40	compared	compare	VERB
admet-390	45	41	to	to	ADP
admet-390	45	42	liver	liver	NOUN
admet-390	45	43	[	[	X
admet-390	45	44	20	20	NUM
admet-390	45	45	]	]	PUNCT
admet-390	45	46	.	.	PUNCT
admet-390	46	1	many	many	ADJ
admet-390	46	2	slc	slc	PROPN
admet-390	46	3	and	and	CCONJ
admet-390	46	4	slco	slco	NOUN
admet-390	46	5	genes	gene	NOUN
admet-390	46	6	were	be	AUX
admet-390	46	7	found	find	VERB
admet-390	46	8	to	to	PART
admet-390	46	9	be	be	AUX
admet-390	46	10	expressed	express	VERB
admet-390	46	11	in	in	ADP
admet-390	46	12	human	human	ADJ
admet-390	46	13	skin	skin	NOUN
admet-390	46	14	[	[	X
admet-390	46	15	23	23	NUM
admet-390	46	16	-	-	SYM
admet-390	46	17	25	25	NUM
admet-390	46	18	]	]	PUNCT
admet-390	46	19	.	.	PUNCT
admet-390	47	1	one	one	NUM
admet-390	47	2	more	more	ADV
admet-390	47	3	recent	recent	ADJ
admet-390	47	4	study	study	NOUN
admet-390	47	5	assessed	assess	VERB
admet-390	47	6	the	the	DET
admet-390	47	7	expression	expression	NOUN
admet-390	47	8	of	of	ADP
admet-390	47	9	slc	slc	PROPN
admet-390	47	10	transporters	transporter	NOUN
admet-390	47	11	in	in	ADP
admet-390	47	12	the	the	DET
admet-390	47	13	human	human	ADJ
admet-390	47	14	skin	skin	NOUN
admet-390	47	15	,	,	PUNCT
admet-390	47	16	liver	liver	NOUN
admet-390	47	17	and	and	CCONJ
admet-390	47	18	small	small	ADJ
admet-390	47	19	intestine	intestine	NOUN
admet-390	47	20	.	.	PUNCT
admet-390	48	1	while	while	SCONJ
admet-390	48	2	most	most	ADJ
admet-390	48	3	of	of	ADP
admet-390	48	4	these	these	DET
admet-390	48	5	transporters	transporter	NOUN
admet-390	48	6	were	be	AUX
admet-390	48	7	moderately	moderately	ADV
admet-390	48	8	to	to	PART
admet-390	48	9	highly	highly	ADV
admet-390	48	10	expressed	express	VERB
admet-390	48	11	in	in	ADP
admet-390	48	12	the	the	DET
admet-390	48	13	liver	liver	NOUN
admet-390	48	14	,	,	PUNCT
admet-390	48	15	their	their	PRON
admet-390	48	16	expression	expression	NOUN
admet-390	48	17	was	be	AUX
admet-390	48	18	limited	limit	VERB
admet-390	48	19	in	in	ADP
admet-390	48	20	the	the	DET
admet-390	48	21	skin	skin	NOUN
admet-390	48	22	and	and	CCONJ
admet-390	48	23	small	small	ADJ
admet-390	48	24	intestine	intestine	NOUN
admet-390	48	25	with	with	ADP
admet-390	48	26	,	,	PUNCT
admet-390	48	27	however	however	ADV
admet-390	48	28	,	,	PUNCT
admet-390	48	29	a	a	DET
admet-390	48	30	rather	rather	ADV
admet-390	48	31	high	high	ADJ
admet-390	48	32	expression	expression	NOUN
admet-390	48	33	of	of	ADP
admet-390	48	34	slco2b1	slco2b1	NUM
admet-390	48	35	,	,	PUNCT
admet-390	48	36	slco4a1	slco4a1	ADV
admet-390	48	37	,	,	PUNCT
admet-390	48	38	slco16a1	slco16a1	PROPN
admet-390	48	39	and	and	CCONJ
admet-390	48	40	slc16a4	slc16a4	VERB
admet-390	48	41	in	in	ADP
admet-390	48	42	the	the	DET
admet-390	48	43	skin	skin	NOUN
admet-390	48	44	[	[	X
admet-390	48	45	25	25	NUM
admet-390	48	46	]	]	PUNCT
admet-390	48	47	.	.	PUNCT
admet-390	49	1	in	in	ADP
admet-390	49	2	another	another	DET
admet-390	49	3	study	study	NOUN
admet-390	49	4	,	,	PUNCT
admet-390	49	5	of	of	ADP
admet-390	49	6	11	11	NUM
admet-390	49	7	transporters	transporter	NOUN
admet-390	49	8	assessed	assess	VERB
admet-390	49	9	slc47a1	slc47a1	NOUN
admet-390	49	10	(	(	PUNCT
admet-390	49	11	mate1	mate1	NOUN
admet-390	49	12	)	)	PUNCT
admet-390	49	13	was	be	AUX
admet-390	49	14	found	find	VERB
admet-390	49	15	with	with	ADP
admet-390	49	16	the	the	DET
admet-390	49	17	highest	high	ADJ
admet-390	49	18	expression	expression	NOUN
admet-390	49	19	in	in	ADP
admet-390	49	20	the	the	DET
admet-390	49	21	skin	skin	NOUN
admet-390	49	22	[	[	X
admet-390	49	23	24	24	NUM
admet-390	49	24	]	]	PUNCT
admet-390	49	25	.	.	PUNCT
admet-390	50	1	comparatively	comparatively	ADV
admet-390	50	2	with	with	ADP
admet-390	50	3	the	the	DET
admet-390	50	4	liver	liver	NOUN
admet-390	50	5	it	it	PRON
admet-390	50	6	was	be	AUX
admet-390	50	7	shown	show	VERB
admet-390	50	8	that	that	SCONJ
admet-390	50	9	quantitatively	quantitatively	ADV
admet-390	50	10	the	the	DET
admet-390	50	11	expression	expression	NOUN
admet-390	50	12	in	in	ADP
admet-390	50	13	the	the	DET
admet-390	50	14	skin	skin	NOUN
admet-390	50	15	is	be	AUX
admet-390	50	16	at	at	ADV
admet-390	50	17	least	least	ADV
admet-390	50	18	10	10	NUM
admet-390	50	19	times	time	NOUN
admet-390	50	20	lower	low	ADJ
admet-390	50	21	than	than	ADP
admet-390	50	22	in	in	ADP
admet-390	50	23	the	the	DET
admet-390	50	24	liver	liver	NOUN
admet-390	50	25	[	[	X
admet-390	50	26	24	24	NUM
admet-390	50	27	]	]	PUNCT
admet-390	50	28	.	.	PUNCT
admet-390	51	1	the	the	DET
admet-390	51	2	study	study	NOUN
admet-390	51	3	of	of	ADP
admet-390	51	4	transporters	transporter	NOUN
admet-390	51	5	in	in	ADP
admet-390	51	6	the	the	DET
admet-390	51	7	human	human	ADJ
admet-390	51	8	skin	skin	NOUN
admet-390	51	9	is	be	AUX
admet-390	51	10	still	still	ADV
admet-390	51	11	in	in	ADP
admet-390	51	12	its	its	PRON
admet-390	51	13	infancy	infancy	NOUN
admet-390	51	14	and	and	CCONJ
admet-390	51	15	in	in	ADP
admet-390	51	16	the	the	DET
admet-390	51	17	2	2	NUM
admet-390	51	18	recent	recent	ADJ
admet-390	51	19	studies	study	NOUN
admet-390	51	20	the	the	DET
admet-390	51	21	expression	expression	NOUN
admet-390	51	22	was	be	AUX
admet-390	51	23	assessed	assess	VERB
admet-390	51	24	by	by	ADP
admet-390	51	25	mrna	mrna	PROPN
admet-390	51	26	levels	level	NOUN
admet-390	51	27	and	and	CCONJ
admet-390	51	28	not	not	PART
admet-390	51	29	by	by	ADP
admet-390	51	30	the	the	DET
admet-390	51	31	protein	protein	NOUN
admet-390	51	32	level	level	NOUN
admet-390	51	33	nor	nor	CCONJ
admet-390	51	34	by	by	ADP
admet-390	51	35	transporter	transporter	NOUN
admet-390	51	36	activity	activity	NOUN
admet-390	51	37	.	.	PUNCT
admet-390	52	1	the	the	DET
admet-390	52	2	issue	issue	NOUN
admet-390	52	3	of	of	ADP
admet-390	52	4	interindividual	interindividual	ADJ
admet-390	52	5	variability	variability	NOUN
admet-390	52	6	observed	observe	VERB
admet-390	52	7	in	in	ADP
admet-390	52	8	the	the	DET
admet-390	52	9	expression	expression	NOUN
admet-390	52	10	is	be	AUX
admet-390	52	11	still	still	ADV
admet-390	52	12	an	an	DET
admet-390	52	13	open	open	ADJ
admet-390	52	14	one	one	NOUN
admet-390	52	15	as	as	SCONJ
admet-390	52	16	the	the	DET
admet-390	52	17	number	number	NOUN
admet-390	52	18	of	of	ADP
admet-390	52	19	skin	skin	NOUN
admet-390	52	20	samples	sample	NOUN
admet-390	52	21	studied	study	VERB
admet-390	52	22	so	so	ADV
admet-390	52	23	far	far	ADV
admet-390	52	24	is	be	AUX
admet-390	52	25	rather	rather	ADV
admet-390	52	26	small	small	ADJ
admet-390	52	27	.	.	PUNCT
admet-390	53	1	the	the	DET
admet-390	53	2	normal	normal	ADJ
admet-390	53	3	variability	variability	NOUN
admet-390	53	4	has	have	VERB
admet-390	53	5	to	to	PART
admet-390	53	6	be	be	AUX
admet-390	53	7	known	know	VERB
admet-390	53	8	before	before	ADP
admet-390	53	9	assessing	assess	VERB
admet-390	53	10	for	for	ADP
admet-390	53	11	example	example	NOUN
admet-390	53	12	the	the	DET
admet-390	53	13	observation	observation	NOUN
admet-390	53	14	that	that	SCONJ
admet-390	53	15	expression	expression	NOUN
admet-390	53	16	of	of	ADP
admet-390	53	17	abcc1	abcc1	PROPN
admet-390	53	18	is	be	AUX
admet-390	53	19	26	26	NUM
admet-390	53	20	fold	fold	ADV
admet-390	53	21	lower	lower	ADV
admet-390	53	22	in	in	ADP
admet-390	53	23	the	the	DET
admet-390	53	24	skin	skin	NOUN
admet-390	53	25	from	from	ADP
admet-390	53	26	skin	skin	NOUN
admet-390	53	27	cancer	cancer	NOUN
admet-390	53	28	patients	patient	NOUN
admet-390	53	29	[	[	X
admet-390	53	30	21	21	NUM
admet-390	53	31	]	]	PUNCT
admet-390	53	32	.	.	PUNCT
admet-390	54	1	expression	expression	NOUN
admet-390	54	2	in	in	ADP
admet-390	54	3	3d	3d	PROPN
admet-390	54	4	human	human	ADJ
admet-390	54	5	skin	skin	NOUN
admet-390	54	6	models	model	NOUN
admet-390	54	7	the	the	DET
admet-390	54	8	main	main	ADJ
admet-390	54	9	abc	abc	PROPN
admet-390	54	10	and	and	CCONJ
admet-390	54	11	slc	slc	PROPN
admet-390	54	12	transporters	transporter	NOUN
admet-390	54	13	expressed	express	VERB
admet-390	54	14	in	in	ADP
admet-390	54	15	full	full	ADJ
admet-390	54	16	thickness	thickness	NOUN
admet-390	54	17	human	human	ADJ
admet-390	54	18	skin	skin	NOUN
admet-390	54	19	in	in	ADP
admet-390	54	20	organ	organ	NOUN
admet-390	54	21	-	-	PUNCT
admet-390	54	22	culture	culture	NOUN
admet-390	54	23	are	be	AUX
admet-390	54	24	also	also	ADV
admet-390	54	25	expressed	express	VERB
admet-390	54	26	in	in	ADP
admet-390	54	27	both	both	CCONJ
admet-390	54	28	3d	3d	PROPN
admet-390	54	29	human	human	ADJ
admet-390	54	30	skin	skin	NOUN
admet-390	54	31	microtissue	microtissue	NOUN
admet-390	54	32	(	(	PUNCT
admet-390	54	33	figure	figure	NOUN
admet-390	54	34	2a	2a	NUM
admet-390	54	35	)	)	PUNCT
admet-390	54	36	and	and	CCONJ
admet-390	54	37	3d	3d	NUM
admet-390	54	38	reconstructed	reconstruct	VERB
admet-390	54	39	human	human	ADJ
admet-390	54	40	epidermis	epidermis	NOUN
admet-390	54	41	(	(	PUNCT
admet-390	54	42	figure	figure	NOUN
admet-390	54	43	2b	2b	NOUN
admet-390	54	44	)	)	PUNCT
admet-390	54	45	.	.	PUNCT
admet-390	55	1	indeed	indeed	ADV
admet-390	55	2	,	,	PUNCT
admet-390	55	3	abcc1	abcc1	PROPN
admet-390	55	4	(	(	PUNCT
admet-390	55	5	mrp1	mrp1	PROPN
admet-390	55	6	)	)	PUNCT
admet-390	55	7	and	and	CCONJ
admet-390	55	8	slc47a1	slc47a1	NOUN
admet-390	55	9	(	(	PUNCT
admet-390	55	10	mate1	mate1	NOUN
admet-390	55	11	)	)	PUNCT
admet-390	55	12	are	be	AUX
admet-390	55	13	clearly	clearly	ADV
admet-390	55	14	expressed	express	VERB
admet-390	55	15	in	in	ADP
admet-390	55	16	those	those	DET
admet-390	55	17	2	2	NUM
admet-390	55	18	models	model	NOUN
admet-390	55	19	,	,	PUNCT
admet-390	55	20	indicating	indicate	VERB
admet-390	55	21	that	that	SCONJ
admet-390	55	22	both	both	DET
admet-390	55	23	3d	3d	NOUN
admet-390	55	24	in	in	ADP
admet-390	55	25	vitro	vitro	X
admet-390	55	26	skin	skin	NOUN
admet-390	55	27	models	model	NOUN
admet-390	55	28	are	be	AUX
admet-390	55	29	suitable	suitable	ADJ
admet-390	55	30	to	to	PART
admet-390	55	31	evaluate	evaluate	VERB
admet-390	55	32	drug	drug	NOUN
admet-390	55	33	transporters	transporter	NOUN
admet-390	55	34	in	in	ADP
admet-390	55	35	the	the	DET
admet-390	55	36	skin	skin	NOUN
admet-390	55	37	by	by	ADP
admet-390	55	38	studying	study	VERB
admet-390	55	39	their	their	PRON
admet-390	55	40	role	role	NOUN
admet-390	55	41	,	,	PUNCT
admet-390	55	42	function	function	NOUN
admet-390	55	43	,	,	PUNCT
admet-390	55	44	and	and	CCONJ
admet-390	55	45	regulation	regulation	NOUN
admet-390	55	46	in	in	ADP
admet-390	55	47	the	the	DET
admet-390	55	48	skin	skin	NOUN
admet-390	55	49	[	[	X
admet-390	55	50	26	26	NUM
admet-390	55	51	]	]	PUNCT
admet-390	55	52	.	.	PUNCT
admet-390	56	1	a	a	DET
admet-390	56	2	b	b	PROPN
admet-390	56	3	h.	h.	PROPN
admet-390	56	4	osman	osman	PROPN
admet-390	56	5	-	-	PUNCT
admet-390	56	6	ponchet	ponchet	NOUN
admet-390	56	7	et	et	PROPN
admet-390	56	8	al	al	PROPN
admet-390	56	9	.	.	PROPN
admet-390	56	10	admet	admet	PROPN
admet-390	56	11	&	&	CCONJ
admet-390	56	12	dmpk	dmpk	PROPN
admet-390	56	13	5(2	5(2	NUM
admet-390	56	14	)	)	PUNCT
admet-390	56	15	(	(	PUNCT
admet-390	56	16	2017	2017	NUM
admet-390	56	17	)	)	PUNCT
admet-390	56	18	75	75	NUM
admet-390	56	19	-	-	SYM
admet-390	56	20	84	84	NUM
admet-390	56	21	78	78	NUM
admet-390	56	22	figure	figure	NOUN
admet-390	56	23	2	2	NUM
admet-390	56	24	.	.	NOUN
admet-390	56	25	constitutive	constitutive	ADJ
admet-390	56	26	expression	expression	NOUN
admet-390	56	27	of	of	ADP
admet-390	56	28	abc	abc	PROPN
admet-390	56	29	and	and	CCONJ
admet-390	56	30	slc	slc	PROPN
admet-390	56	31	transporters	transporter	NOUN
admet-390	56	32	in	in	ADP
admet-390	56	33	3d	3d	NUM
admet-390	56	34	in	in	ADP
admet-390	56	35	vitro	vitro	X
admet-390	56	36	human	human	ADJ
admet-390	56	37	skin	skin	NOUN
admet-390	56	38	models	model	NOUN
admet-390	56	39	.	.	PUNCT
admet-390	57	1	(	(	PUNCT
admet-390	57	2	a	a	X
admet-390	57	3	)	)	PUNCT
admet-390	57	4	3d	3d	PROPN
admet-390	57	5	human	human	ADJ
admet-390	57	6	skin	skin	NOUN
admet-390	57	7	microtissue	microtissue	NOUN
admet-390	57	8	.	.	PUNCT
admet-390	58	1	(	(	PUNCT
admet-390	58	2	b	b	X
admet-390	58	3	)	)	PUNCT
admet-390	58	4	3d	3d	NOUN
admet-390	58	5	reconstructed	reconstruct	VERB
admet-390	58	6	human	human	ADJ
admet-390	58	7	epidermis	epidermis	NOUN
admet-390	58	8	.	.	PUNCT
admet-390	59	1	quantitative	quantitative	ADJ
admet-390	59	2	real	real	ADJ
admet-390	59	3	-	-	PUNCT
admet-390	59	4	time	time	NOUN
admet-390	59	5	reverse	reverse	ADJ
admet-390	59	6	transcription	transcription	NOUN
admet-390	59	7	-	-	PUNCT
admet-390	59	8	pcr	pcr	NOUN
admet-390	59	9	was	be	AUX
admet-390	59	10	used	use	VERB
admet-390	59	11	to	to	PART
admet-390	59	12	investigate	investigate	VERB
admet-390	59	13	the	the	DET
admet-390	59	14	constitutive	constitutive	ADJ
admet-390	59	15	expression	expression	NOUN
admet-390	59	16	of	of	ADP
admet-390	59	17	abc	abc	PROPN
admet-390	59	18	and	and	CCONJ
admet-390	59	19	slc	slc	PROPN
admet-390	59	20	transporters	transporter	NOUN
admet-390	59	21	in	in	ADP
admet-390	59	22	3d	3d	PROPN
admet-390	59	23	human	human	ADJ
admet-390	59	24	skin	skin	NOUN
admet-390	59	25	models	model	NOUN
admet-390	59	26	.	.	PUNCT
admet-390	60	1	gene	gene	NOUN
admet-390	60	2	expression	expression	NOUN
admet-390	60	3	was	be	AUX
admet-390	60	4	normalized	normalize	VERB
admet-390	60	5	to	to	ADP
admet-390	60	6	3d	3d	PROPN
admet-390	60	7	human	human	ADJ
admet-390	60	8	skin	skin	NOUN
admet-390	60	9	microtissue	microtissue	NOUN
admet-390	60	10	and	and	CCONJ
admet-390	60	11	reconstructed	reconstruct	VERB
admet-390	60	12	human	human	ADJ
admet-390	60	13	epidermis	epidermis	NOUN
admet-390	60	14	gapdh	gapdh	NOUN
admet-390	60	15	to	to	PART
admet-390	60	16	ensure	ensure	VERB
admet-390	60	17	equality	equality	NOUN
admet-390	60	18	of	of	ADP
admet-390	60	19	loading	loading	NOUN
admet-390	60	20	.	.	PUNCT
admet-390	61	1	all	all	DET
admet-390	61	2	analyses	analysis	NOUN
admet-390	61	3	were	be	AUX
admet-390	61	4	performed	perform	VERB
admet-390	61	5	in	in	ADP
admet-390	61	6	triplicate	triplicate	NOUN
admet-390	61	7	.	.	PUNCT
admet-390	62	1	expression	expression	NOUN
admet-390	62	2	in	in	ADP
admet-390	62	3	skin	skin	NOUN
admet-390	62	4	from	from	ADP
admet-390	62	5	animal	animal	NOUN
admet-390	62	6	species	specie	NOUN
admet-390	62	7	abcc1	abcc1	NOUN
admet-390	62	8	is	be	AUX
admet-390	62	9	the	the	DET
admet-390	62	10	main	main	ADJ
admet-390	62	11	abc	abc	NOUN
admet-390	62	12	transporter	transporter	NOUN
admet-390	62	13	expressed	express	VERB
admet-390	62	14	in	in	ADP
admet-390	62	15	human	human	ADJ
admet-390	62	16	skin	skin	NOUN
admet-390	62	17	,	,	PUNCT
admet-390	62	18	in	in	ADP
admet-390	62	19	göttingen	göttingen	NOUN
admet-390	62	20	mini	mini	ADJ
admet-390	62	21	pig	pig	NOUN
admet-390	62	22	skin	skin	NOUN
admet-390	62	23	,	,	PUNCT
admet-390	62	24	and	and	CCONJ
admet-390	62	25	in	in	ADP
admet-390	62	26	sprague	sprague	NOUN
admet-390	62	27	dawley	dawley	PROPN
admet-390	62	28	rat	rat	NOUN
admet-390	62	29	skin	skin	NOUN
admet-390	62	30	(	(	PUNCT
admet-390	62	31	figure	figure	NOUN
admet-390	62	32	3a	3a	NUM
admet-390	62	33	)	)	PUNCT
admet-390	62	34	.	.	PUNCT
admet-390	63	1	slc47a1	slc47a1	NOUN
admet-390	63	2	is	be	AUX
admet-390	63	3	the	the	DET
admet-390	63	4	main	main	ADJ
admet-390	63	5	slc	slc	PROPN
admet-390	63	6	transporter	transporter	NOUN
admet-390	63	7	expressed	express	VERB
admet-390	63	8	in	in	ADP
admet-390	63	9	human	human	ADJ
admet-390	63	10	skin	skin	NOUN
admet-390	63	11	and	and	CCONJ
admet-390	63	12	in	in	ADP
admet-390	63	13	rat	rat	NOUN
admet-390	63	14	skin	skin	NOUN
admet-390	63	15	(	(	PUNCT
admet-390	63	16	figure	figure	NOUN
admet-390	63	17	3b	3b	NUM
admet-390	63	18	)	)	PUNCT
admet-390	63	19	.	.	PUNCT
admet-390	64	1	moreover	moreover	ADV
admet-390	64	2	,	,	PUNCT
admet-390	64	3	the	the	DET
admet-390	64	4	expression	expression	NOUN
admet-390	64	5	of	of	ADP
admet-390	64	6	slc47a1	slc47a1	NOUN
admet-390	64	7	is	be	AUX
admet-390	64	8	higher	high	ADJ
admet-390	64	9	in	in	ADP
admet-390	64	10	human	human	ADJ
admet-390	64	11	skin	skin	NOUN
admet-390	64	12	compared	compare	VERB
admet-390	64	13	to	to	ADP
admet-390	64	14	rat	rat	NOUN
admet-390	64	15	skin	skin	NOUN
admet-390	64	16	.	.	PUNCT
admet-390	65	1	of	of	ADP
admet-390	65	2	the	the	DET
admet-390	65	3	four	four	NUM
admet-390	65	4	slc	slc	PROPN
admet-390	65	5	transporters	transporter	NOUN
admet-390	65	6	tested	test	VERB
admet-390	65	7	,	,	PUNCT
admet-390	65	8	none	none	NOUN
admet-390	65	9	was	be	AUX
admet-390	65	10	expressed	express	VERB
admet-390	65	11	in	in	ADP
admet-390	65	12	mini	mini	ADJ
admet-390	65	13	pig	pig	NOUN
admet-390	65	14	skin	skin	NOUN
admet-390	65	15	,	,	PUNCT
admet-390	65	16	however	however	ADV
admet-390	65	17	,	,	PUNCT
admet-390	65	18	it	it	PRON
admet-390	65	19	should	should	AUX
admet-390	65	20	be	be	AUX
admet-390	65	21	noted	note	VERB
admet-390	65	22	that	that	SCONJ
admet-390	65	23	at	at	ADP
admet-390	65	24	present	present	ADJ
admet-390	65	25	time	time	NOUN
admet-390	65	26	,	,	PUNCT
admet-390	65	27	the	the	DET
admet-390	65	28	gene	gene	NOUN
admet-390	65	29	sequence	sequence	NOUN
admet-390	65	30	of	of	ADP
admet-390	65	31	slc47a1	slc47a1	NOUN
admet-390	65	32	is	be	AUX
admet-390	65	33	not	not	PART
admet-390	65	34	yet	yet	ADV
admet-390	65	35	known	know	VERB
admet-390	65	36	in	in	ADP
admet-390	65	37	mini	mini	ADJ
admet-390	65	38	pig	pig	NOUN
admet-390	65	39	.	.	PUNCT
admet-390	66	1	overall	overall	ADV
admet-390	66	2	,	,	PUNCT
admet-390	66	3	these	these	DET
admet-390	66	4	results	result	NOUN
admet-390	66	5	show	show	VERB
admet-390	66	6	that	that	SCONJ
admet-390	66	7	expression	expression	NOUN
admet-390	66	8	profile	profile	NOUN
admet-390	66	9	of	of	ADP
admet-390	66	10	abc	abc	PROPN
admet-390	66	11	and	and	CCONJ
admet-390	66	12	slc	slc	PROPN
admet-390	66	13	transporters	transporter	NOUN
admet-390	66	14	is	be	AUX
admet-390	66	15	qualitatively	qualitatively	ADV
admet-390	66	16	similar	similar	ADJ
admet-390	66	17	in	in	ADP
admet-390	66	18	skin	skin	NOUN
admet-390	66	19	of	of	ADP
admet-390	66	20	human	human	ADJ
admet-390	66	21	and	and	CCONJ
admet-390	66	22	animal	animal	NOUN
admet-390	66	23	species	specie	NOUN
admet-390	66	24	tested	test	VERB
admet-390	66	25	.	.	PUNCT
admet-390	67	1	a	a	DET
admet-390	67	2	b	b	PROPN
admet-390	67	3	admet	admet	X
admet-390	67	4	&	&	CCONJ
admet-390	67	5	dmpk	dmpk	PROPN
admet-390	67	6	5(2	5(2	NUM
admet-390	67	7	)	)	PUNCT
admet-390	67	8	(	(	PUNCT
admet-390	67	9	2017	2017	NUM
admet-390	67	10	)	)	PUNCT
admet-390	67	11	75	75	NUM
admet-390	67	12	-	-	SYM
admet-390	67	13	84	84	NUM
admet-390	67	14	expression	expression	NOUN
admet-390	67	15	of	of	ADP
admet-390	67	16	drug	drug	NOUN
admet-390	67	17	transporters	transporter	NOUN
admet-390	67	18	in	in	ADP
admet-390	67	19	the	the	DET
admet-390	67	20	human	human	ADJ
admet-390	67	21	skin	skin	NOUN
admet-390	67	22	doi	doi	NOUN
admet-390	67	23	:	:	PUNCT
admet-390	67	24	10.5599	10.5599	NUM
admet-390	67	25	/	/	SYM
admet-390	67	26	admet.5.2.390	admet.5.2.390	PROPN
admet-390	67	27	79	79	NUM
admet-390	67	28	figure	figure	NOUN
admet-390	67	29	3	3	NUM
admet-390	67	30	.	.	NOUN
admet-390	67	31	constitutive	constitutive	ADJ
admet-390	67	32	expression	expression	NOUN
admet-390	67	33	of	of	ADP
admet-390	67	34	abc	abc	PROPN
admet-390	67	35	and	and	CCONJ
admet-390	67	36	slc	slc	PROPN
admet-390	67	37	transporters	transporter	NOUN
admet-390	67	38	in	in	ADP
admet-390	67	39	skin	skin	NOUN
admet-390	67	40	of	of	ADP
admet-390	67	41	different	different	ADJ
admet-390	67	42	animal	animal	NOUN
admet-390	67	43	species	specie	NOUN
admet-390	67	44	.	.	PUNCT
admet-390	68	1	(	(	PUNCT
admet-390	68	2	a	a	X
admet-390	68	3	)	)	PUNCT
admet-390	68	4	expression	expression	NOUN
admet-390	68	5	of	of	ADP
admet-390	68	6	abc	abc	PROPN
admet-390	68	7	transporters	transporter	NOUN
admet-390	68	8	in	in	ADP
admet-390	68	9	rat	rat	NOUN
admet-390	68	10	,	,	PUNCT
admet-390	68	11	mini	mini	ADJ
admet-390	68	12	pig	pig	NOUN
admet-390	68	13	and	and	CCONJ
admet-390	68	14	human	human	ADJ
admet-390	68	15	skin	skin	NOUN
admet-390	68	16	.	.	PUNCT
admet-390	69	1	(	(	PUNCT
admet-390	69	2	b	b	X
admet-390	69	3	)	)	PUNCT
admet-390	69	4	expression	expression	NOUN
admet-390	69	5	of	of	ADP
admet-390	69	6	slc	slc	PROPN
admet-390	69	7	transporters	transporter	NOUN
admet-390	69	8	in	in	ADP
admet-390	69	9	rat	rat	NOUN
admet-390	69	10	and	and	CCONJ
admet-390	69	11	human	human	ADJ
admet-390	69	12	skin	skin	NOUN
admet-390	69	13	.	.	PUNCT
admet-390	70	1	quantitative	quantitative	ADJ
admet-390	70	2	real	real	ADJ
admet-390	70	3	-	-	PUNCT
admet-390	70	4	time	time	NOUN
admet-390	70	5	reverse	reverse	ADJ
admet-390	70	6	transcription	transcription	NOUN
admet-390	70	7	-	-	PUNCT
admet-390	70	8	pcr	pcr	NOUN
admet-390	70	9	was	be	AUX
admet-390	70	10	used	use	VERB
admet-390	70	11	to	to	PART
admet-390	70	12	investigate	investigate	VERB
admet-390	70	13	the	the	DET
admet-390	70	14	constitutive	constitutive	ADJ
admet-390	70	15	expression	expression	NOUN
admet-390	70	16	of	of	ADP
admet-390	70	17	abc	abc	PROPN
admet-390	70	18	and	and	CCONJ
admet-390	70	19	slc	slc	PROPN
admet-390	70	20	transporters	transporter	NOUN
admet-390	70	21	in	in	ADP
admet-390	70	22	animal	animal	NOUN
admet-390	70	23	skin	skin	NOUN
admet-390	70	24	.	.	PUNCT
admet-390	71	1	gene	gene	NOUN
admet-390	71	2	expression	expression	NOUN
admet-390	71	3	was	be	AUX
admet-390	71	4	normalized	normalize	VERB
admet-390	71	5	to	to	PART
admet-390	71	6	gapdh	gapdh	VERB
admet-390	71	7	to	to	PART
admet-390	71	8	ensure	ensure	VERB
admet-390	71	9	equality	equality	NOUN
admet-390	71	10	of	of	ADP
admet-390	71	11	loading	loading	NOUN
admet-390	71	12	.	.	PUNCT
admet-390	72	1	all	all	DET
admet-390	72	2	analyses	analysis	NOUN
admet-390	72	3	were	be	AUX
admet-390	72	4	performed	perform	VERB
admet-390	72	5	in	in	ADP
admet-390	72	6	triplicate	triplicate	NOUN
admet-390	72	7	.	.	PUNCT
admet-390	73	1	regulation	regulation	NOUN
admet-390	73	2	of	of	ADP
admet-390	73	3	transporter	transporter	NOUN
admet-390	73	4	expression	expression	NOUN
admet-390	73	5	in	in	ADP
admet-390	73	6	the	the	DET
admet-390	73	7	skin	skin	NOUN
admet-390	73	8	the	the	DET
admet-390	73	9	effect	effect	NOUN
admet-390	73	10	of	of	ADP
admet-390	73	11	rifampicin	rifampicin	VERB
admet-390	73	12	on	on	ADP
admet-390	73	13	the	the	DET
admet-390	73	14	expression	expression	NOUN
admet-390	73	15	of	of	ADP
admet-390	73	16	abcc1	abcc1	PROPN
admet-390	73	17	and	and	CCONJ
admet-390	73	18	slc47a1	slc47a1	NOUN
admet-390	73	19	,	,	PUNCT
admet-390	73	20	the	the	DET
admet-390	73	21	most	most	ADV
admet-390	73	22	expressed	express	VERB
admet-390	73	23	transporters	transporter	NOUN
admet-390	73	24	in	in	ADP
admet-390	73	25	the	the	DET
admet-390	73	26	skin	skin	NOUN
admet-390	73	27	,	,	PUNCT
admet-390	73	28	was	be	AUX
admet-390	73	29	studied	study	VERB
admet-390	73	30	in	in	ADP
admet-390	73	31	human	human	ADJ
admet-390	73	32	skin	skin	NOUN
admet-390	73	33	organ	organ	NOUN
admet-390	73	34	-	-	PUNCT
admet-390	73	35	culture	culture	NOUN
admet-390	73	36	after	after	ADP
admet-390	73	37	a	a	DET
admet-390	73	38	72	72	NUM
admet-390	73	39	hour	hour	NOUN
admet-390	73	40	treatment	treatment	NOUN
admet-390	73	41	period	period	NOUN
admet-390	73	42	[	[	X
admet-390	73	43	20	20	NUM
admet-390	73	44	,	,	PUNCT
admet-390	73	45	24	24	NUM
admet-390	73	46	]	]	PUNCT
admet-390	73	47	.	.	PUNCT
admet-390	74	1	rifampicin	rifampicin	PROPN
admet-390	74	2	induced	induce	VERB
admet-390	74	3	a	a	DET
admet-390	74	4	significant	significant	ADJ
admet-390	74	5	decrease	decrease	NOUN
admet-390	74	6	of	of	ADP
admet-390	74	7	expression	expression	NOUN
admet-390	74	8	of	of	ADP
admet-390	74	9	abcc1	abcc1	PROPN
admet-390	75	1	[	[	X
admet-390	75	2	20	20	NUM
admet-390	75	3	]	]	PUNCT
admet-390	75	4	and	and	CCONJ
admet-390	75	5	slc47a1	slc47a1	NOUN
admet-390	75	6	[	[	X
admet-390	75	7	24	24	NUM
admet-390	75	8	]	]	PUNCT
admet-390	75	9	.	.	PUNCT
admet-390	76	1	expression	expression	NOUN
admet-390	76	2	of	of	ADP
admet-390	76	3	slc47a2	slc47a2	PROPN
admet-390	76	4	was	be	AUX
admet-390	76	5	also	also	ADV
admet-390	76	6	decreased	decrease	VERB
admet-390	76	7	but	but	CCONJ
admet-390	76	8	not	not	PART
admet-390	76	9	to	to	ADP
admet-390	76	10	a	a	DET
admet-390	76	11	significant	significant	ADJ
admet-390	76	12	level	level	NOUN
admet-390	76	13	due	due	ADP
admet-390	76	14	to	to	ADP
admet-390	76	15	the	the	DET
admet-390	76	16	variability	variability	NOUN
admet-390	76	17	of	of	ADP
admet-390	76	18	expression	expression	NOUN
admet-390	76	19	.	.	PUNCT
admet-390	77	1	interestingly	interestingly	ADV
admet-390	77	2	uv	uv	NOUN
admet-390	77	3	light	light	ADJ
admet-390	77	4	exposure	exposure	NOUN
admet-390	77	5	decreased	decrease	VERB
admet-390	77	6	the	the	DET
admet-390	77	7	expression	expression	NOUN
admet-390	77	8	of	of	ADP
admet-390	77	9	both	both	DET
admet-390	77	10	slc47a1	slc47a1	NOUN
admet-390	77	11	and	and	CCONJ
admet-390	77	12	slc47a2	slc47a2	ADJ
admet-390	77	13	,	,	PUNCT
admet-390	77	14	and	and	CCONJ
admet-390	77	15	again	again	ADV
admet-390	77	16	there	there	PRON
admet-390	77	17	is	be	VERB
admet-390	77	18	a	a	DET
admet-390	77	19	large	large	ADJ
admet-390	77	20	interindividual	interindividual	ADJ
admet-390	77	21	variability	variability	NOUN
admet-390	77	22	and	and	CCONJ
admet-390	77	23	the	the	DET
admet-390	77	24	decrease	decrease	NOUN
admet-390	77	25	is	be	AUX
admet-390	77	26	not	not	PART
admet-390	77	27	significant	significant	ADJ
admet-390	77	28	for	for	ADP
admet-390	77	29	slc47a2	slc47a2	PROPN
admet-390	77	30	[	[	X
admet-390	77	31	24	24	NUM
admet-390	77	32	]	]	PUNCT
admet-390	77	33	.	.	PUNCT
admet-390	78	1	it	it	PRON
admet-390	78	2	is	be	AUX
admet-390	78	3	difficult	difficult	ADJ
admet-390	78	4	at	at	ADP
admet-390	78	5	this	this	DET
admet-390	78	6	stage	stage	NOUN
admet-390	78	7	to	to	PART
admet-390	78	8	draw	draw	VERB
admet-390	78	9	firm	firm	ADJ
admet-390	78	10	conclusions	conclusion	NOUN
admet-390	78	11	as	as	ADP
admet-390	78	12	the	the	DET
admet-390	78	13	variability	variability	NOUN
admet-390	78	14	in	in	ADP
admet-390	78	15	the	the	DET
admet-390	78	16	expression	expression	NOUN
admet-390	78	17	blunts	blunt	NOUN
admet-390	78	18	the	the	DET
admet-390	78	19	results	result	NOUN
admet-390	78	20	,	,	PUNCT
admet-390	78	21	but	but	CCONJ
admet-390	78	22	there	there	PRON
admet-390	78	23	is	be	VERB
admet-390	78	24	nevertheless	nevertheless	ADV
admet-390	78	25	a	a	DET
admet-390	78	26	trend	trend	NOUN
admet-390	78	27	towards	towards	ADP
admet-390	78	28	regulation	regulation	NOUN
admet-390	78	29	of	of	ADP
admet-390	78	30	a	a	DET
admet-390	78	31	few	few	ADJ
admet-390	78	32	transporters	transporter	NOUN
admet-390	78	33	in	in	ADP
admet-390	78	34	the	the	DET
admet-390	78	35	skin	skin	NOUN
admet-390	78	36	.	.	PUNCT
admet-390	79	1	this	this	DET
admet-390	79	2	aspect	aspect	NOUN
admet-390	79	3	should	should	AUX
admet-390	79	4	receive	receive	VERB
admet-390	79	5	more	more	ADJ
admet-390	79	6	attention	attention	NOUN
admet-390	79	7	in	in	ADP
admet-390	79	8	the	the	DET
admet-390	79	9	future	future	NOUN
admet-390	79	10	.	.	PUNCT
admet-390	80	1	localization	localization	NOUN
admet-390	80	2	and	and	CCONJ
admet-390	80	3	function	function	NOUN
admet-390	80	4	of	of	ADP
admet-390	80	5	transporters	transporter	NOUN
admet-390	80	6	in	in	ADP
admet-390	80	7	the	the	DET
admet-390	80	8	skin	skin	NOUN
admet-390	80	9	the	the	DET
admet-390	80	10	skin	skin	NOUN
admet-390	80	11	is	be	AUX
admet-390	80	12	not	not	PART
admet-390	80	13	a	a	DET
admet-390	80	14	homogeneous	homogeneous	ADJ
admet-390	80	15	organ	organ	NOUN
admet-390	80	16	,	,	PUNCT
admet-390	80	17	so	so	SCONJ
admet-390	80	18	a	a	DET
admet-390	80	19	differential	differential	ADJ
admet-390	80	20	expression	expression	NOUN
admet-390	80	21	of	of	ADP
admet-390	80	22	transporters	transporter	NOUN
admet-390	80	23	in	in	ADP
admet-390	80	24	different	different	ADJ
admet-390	80	25	skin	skin	NOUN
admet-390	80	26	compartments	compartment	NOUN
admet-390	80	27	would	would	AUX
admet-390	80	28	not	not	PART
admet-390	80	29	be	be	AUX
admet-390	80	30	unexpected	unexpected	ADJ
admet-390	80	31	.	.	PUNCT
admet-390	81	1	expression	expression	NOUN
admet-390	81	2	of	of	ADP
admet-390	81	3	abcb1	abcb1	NOUN
admet-390	81	4	in	in	ADP
admet-390	81	5	human	human	ADJ
admet-390	81	6	skin	skin	NOUN
admet-390	81	7	was	be	AUX
admet-390	81	8	found	find	VERB
admet-390	81	9	to	to	PART
admet-390	81	10	be	be	AUX
admet-390	81	11	mainly	mainly	ADV
admet-390	81	12	restricted	restrict	VERB
admet-390	81	13	to	to	PART
admet-390	81	14	dermal	dermal	VERB
admet-390	81	15	components	component	NOUN
admet-390	82	1	[	[	X
admet-390	82	2	22	22	NUM
admet-390	82	3	]	]	PUNCT
admet-390	82	4	,	,	PUNCT
admet-390	82	5	sweat	sweat	NOUN
admet-390	82	6	ducts	duct	NOUN
admet-390	82	7	,	,	PUNCT
admet-390	82	8	vessels	vessel	NOUN
admet-390	82	9	,	,	PUNCT
admet-390	82	10	nerve	nerve	NOUN
admet-390	82	11	sheaths	sheath	NOUN
admet-390	82	12	and	and	CCONJ
admet-390	82	13	muscle	muscle	NOUN
admet-390	82	14	[	[	X
admet-390	82	15	27	27	NUM
admet-390	82	16	]	]	PUNCT
admet-390	82	17	,	,	PUNCT
admet-390	82	18	confirming	confirm	VERB
admet-390	82	19	an	an	DET
admet-390	82	20	earlier	early	ADJ
admet-390	82	21	observation	observation	NOUN
admet-390	82	22	in	in	ADP
admet-390	82	23	which	which	PRON
admet-390	82	24	p	p	NOUN
admet-390	82	25	-	-	NOUN
admet-390	82	26	gp	gp	NOUN
admet-390	82	27	in	in	ADP
admet-390	82	28	neonatal	neonatal	ADJ
admet-390	82	29	murine	murine	ADJ
admet-390	82	30	skin	skin	NOUN
admet-390	82	31	were	be	AUX
admet-390	82	32	present	present	ADJ
admet-390	82	33	on	on	ADP
admet-390	82	34	the	the	DET
admet-390	82	35	surface	surface	NOUN
admet-390	82	36	of	of	ADP
admet-390	82	37	basal	basal	NOUN
admet-390	82	38	a	a	DET
admet-390	82	39	b	b	PROPN
admet-390	82	40	h.	h.	PROPN
admet-390	82	41	osman	osman	PROPN
admet-390	82	42	-	-	PUNCT
admet-390	82	43	ponchet	ponchet	NOUN
admet-390	82	44	et	et	PROPN
admet-390	82	45	al	al	PROPN
admet-390	82	46	.	.	PROPN
admet-390	82	47	admet	admet	PROPN
admet-390	82	48	&	&	CCONJ
admet-390	82	49	dmpk	dmpk	PROPN
admet-390	82	50	5(2	5(2	NUM
admet-390	82	51	)	)	PUNCT
admet-390	82	52	(	(	PUNCT
admet-390	82	53	2017	2017	NUM
admet-390	82	54	)	)	PUNCT
admet-390	82	55	75	75	NUM
admet-390	82	56	-	-	SYM
admet-390	82	57	84	84	NUM
admet-390	82	58	80	80	NUM
admet-390	82	59	keratinocytes	keratinocyte	NOUN
admet-390	82	60	and	and	CCONJ
admet-390	82	61	outer	outer	ADJ
admet-390	82	62	root	root	NOUN
admet-390	82	63	sheath	sheath	NOUN
admet-390	82	64	cells	cell	NOUN
admet-390	82	65	of	of	ADP
admet-390	82	66	hair	hair	NOUN
admet-390	82	67	follicles	follicle	NOUN
admet-390	82	68	[	[	X
admet-390	82	69	28	28	NUM
admet-390	82	70	]	]	PUNCT
admet-390	82	71	.	.	PUNCT
admet-390	83	1	as	as	SCONJ
admet-390	83	2	a	a	DET
admet-390	83	3	monoclonal	monoclonal	NOUN
admet-390	83	4	antibody	antibody	NOUN
admet-390	83	5	for	for	ADP
admet-390	83	6	human	human	ADJ
admet-390	83	7	mrp1	mrp1	PROPN
admet-390	83	8	is	be	AUX
admet-390	83	9	available	available	ADJ
admet-390	83	10	we	we	PRON
admet-390	83	11	studied	study	VERB
admet-390	83	12	the	the	DET
admet-390	83	13	localization	localization	NOUN
admet-390	83	14	of	of	ADP
admet-390	83	15	this	this	DET
admet-390	83	16	transporter	transporter	NOUN
admet-390	83	17	by	by	ADP
admet-390	83	18	immunohistochemistry	immunohistochemistry	NOUN
admet-390	83	19	,	,	PUNCT
admet-390	83	20	and	and	CCONJ
admet-390	83	21	it	it	PRON
admet-390	83	22	was	be	AUX
admet-390	83	23	found	find	VERB
admet-390	83	24	that	that	SCONJ
admet-390	83	25	mrp1	mrp1	NOUN
admet-390	83	26	is	be	AUX
admet-390	83	27	mainly	mainly	ADV
admet-390	83	28	localized	localize	VERB
admet-390	83	29	at	at	ADP
admet-390	83	30	the	the	DET
admet-390	83	31	interface	interface	NOUN
admet-390	83	32	of	of	ADP
admet-390	83	33	epidermis	epidermis	NOUN
admet-390	83	34	-	-	PUNCT
admet-390	83	35	dermis	dermis	NOUN
admet-390	83	36	and	and	CCONJ
admet-390	83	37	in	in	ADP
admet-390	83	38	the	the	DET
admet-390	83	39	dermis	dermis	NOUN
admet-390	83	40	in	in	ADP
admet-390	83	41	the	the	DET
admet-390	83	42	sweat	sweat	NOUN
admet-390	83	43	gland	gland	NOUN
admet-390	84	1	[	[	X
admet-390	84	2	20	20	NUM
admet-390	84	3	]	]	PUNCT
admet-390	84	4	and	and	CCONJ
admet-390	84	5	hair	hair	NOUN
admet-390	84	6	follicle	follicle	NOUN
admet-390	84	7	(	(	PUNCT
admet-390	84	8	figure	figure	NOUN
admet-390	84	9	4	4	NUM
admet-390	84	10	)	)	PUNCT
admet-390	84	11	.	.	PUNCT
admet-390	85	1	the	the	DET
admet-390	85	2	concentration	concentration	NOUN
admet-390	85	3	of	of	ADP
admet-390	85	4	expression	expression	NOUN
admet-390	85	5	of	of	ADP
admet-390	85	6	mrp1	mrp1	NOUN
admet-390	85	7	in	in	ADP
admet-390	85	8	the	the	DET
admet-390	85	9	hair	hair	NOUN
admet-390	85	10	follicle	follicle	NOUN
admet-390	85	11	was	be	AUX
admet-390	85	12	confirmed	confirm	VERB
admet-390	85	13	in	in	ADP
admet-390	85	14	a	a	DET
admet-390	85	15	more	more	ADV
admet-390	85	16	recent	recent	ADJ
admet-390	85	17	study	study	NOUN
admet-390	85	18	[	[	X
admet-390	85	19	19	19	NUM
admet-390	85	20	]	]	PUNCT
admet-390	85	21	.	.	PUNCT
admet-390	86	1	on	on	ADP
admet-390	86	2	the	the	DET
admet-390	86	3	other	other	ADJ
admet-390	86	4	hand	hand	NOUN
admet-390	86	5	,	,	PUNCT
admet-390	86	6	bcrp	bcrp	PROPN
admet-390	86	7	was	be	AUX
admet-390	86	8	immunohistochemically	immunohistochemically	ADV
admet-390	86	9	identified	identify	VERB
admet-390	86	10	in	in	ADP
admet-390	86	11	human	human	ADJ
admet-390	86	12	epidermis	epidermis	NOUN
admet-390	86	13	and	and	CCONJ
admet-390	86	14	dermal	dermal	VERB
admet-390	86	15	endothelial	endothelial	NOUN
admet-390	86	16	cells	cell	NOUN
admet-390	86	17	[	[	X
admet-390	86	18	21	21	NUM
admet-390	86	19	]	]	PUNCT
admet-390	86	20	and	and	CCONJ
admet-390	86	21	in	in	ADP
admet-390	86	22	the	the	DET
admet-390	86	23	hair	hair	NOUN
admet-390	86	24	follicle	follicle	NOUN
admet-390	87	1	[	[	X
admet-390	87	2	22	22	NUM
admet-390	87	3	]	]	PUNCT
admet-390	87	4	.	.	PUNCT
admet-390	88	1	there	there	PRON
admet-390	88	2	are	be	VERB
admet-390	88	3	less	less	ADJ
admet-390	88	4	data	datum	NOUN
admet-390	88	5	about	about	ADP
admet-390	88	6	the	the	DET
admet-390	88	7	localization	localization	NOUN
admet-390	88	8	of	of	ADP
admet-390	88	9	slc	slc	PROPN
admet-390	88	10	transporters	transporter	NOUN
admet-390	88	11	in	in	ADP
admet-390	88	12	the	the	DET
admet-390	88	13	skin	skin	NOUN
admet-390	88	14	;	;	PUNCT
admet-390	88	15	in	in	ADP
admet-390	88	16	one	one	NUM
admet-390	88	17	study	study	NOUN
admet-390	88	18	slc21a9	slc21a9	NOUN
admet-390	88	19	/	/	SYM
admet-390	88	20	oatp	oatp	ADJ
admet-390	88	21	-	-	PUNCT
admet-390	88	22	b	b	NOUN
admet-390	88	23	was	be	AUX
admet-390	88	24	detected	detect	VERB
admet-390	88	25	in	in	ADP
admet-390	88	26	the	the	DET
admet-390	88	27	epidermis	epidermis	NOUN
admet-390	88	28	of	of	ADP
admet-390	88	29	skin	skin	NOUN
admet-390	88	30	specimens	specimen	NOUN
admet-390	88	31	by	by	ADP
admet-390	88	32	immunofluorescence	immunofluorescence	NOUN
admet-390	88	33	and	and	CCONJ
admet-390	88	34	immunohistochemistry	immunohistochemistry	NOUN
admet-390	89	1	[	[	X
admet-390	89	2	9	9	NUM
admet-390	89	3	]	]	PUNCT
admet-390	89	4	.	.	PUNCT
admet-390	90	1	figure	figure	NOUN
admet-390	90	2	4	4	NUM
admet-390	90	3	.	.	PUNCT
admet-390	91	1	localization	localization	NOUN
admet-390	91	2	of	of	ADP
admet-390	91	3	mrp1	mrp1	NOUN
admet-390	91	4	in	in	ADP
admet-390	91	5	the	the	DET
admet-390	91	6	hair	hair	NOUN
admet-390	91	7	follicle	follicle	NOUN
admet-390	91	8	by	by	ADP
admet-390	91	9	immunohistochemistry	immunohistochemistry	NOUN
admet-390	91	10	.	.	PUNCT
admet-390	92	1	potential	potential	ADJ
admet-390	92	2	function	function	NOUN
admet-390	92	3	of	of	ADP
admet-390	92	4	drug	drug	NOUN
admet-390	92	5	transporters	transporter	NOUN
admet-390	92	6	in	in	ADP
admet-390	92	7	the	the	DET
admet-390	92	8	skin	skin	NOUN
admet-390	92	9	mdr1	mdr1	PROPN
admet-390	92	10	/	/	SYM
admet-390	92	11	p	p	NOUN
admet-390	92	12	-	-	PUNCT
admet-390	92	13	gp	gp	NOUN
admet-390	92	14	is	be	AUX
admet-390	92	15	thought	think	VERB
admet-390	92	16	to	to	PART
admet-390	92	17	be	be	AUX
admet-390	92	18	an	an	DET
admet-390	92	19	efflux	efflux	NOUN
admet-390	92	20	transporter	transporter	NOUN
admet-390	92	21	so	so	SCONJ
admet-390	92	22	it	it	PRON
admet-390	92	23	was	be	AUX
admet-390	92	24	a	a	DET
admet-390	92	25	kind	kind	NOUN
admet-390	92	26	of	of	ADP
admet-390	92	27	a	a	DET
admet-390	92	28	surprise	surprise	NOUN
admet-390	92	29	when	when	SCONJ
admet-390	92	30	this	this	DET
admet-390	92	31	transporter	transporter	NOUN
admet-390	92	32	was	be	AUX
admet-390	92	33	found	find	VERB
admet-390	92	34	to	to	PART
admet-390	92	35	be	be	AUX
admet-390	92	36	involved	involve	VERB
admet-390	92	37	in	in	ADP
admet-390	92	38	the	the	DET
admet-390	92	39	absorptive	absorptive	ADJ
admet-390	92	40	drug	drug	NOUN
admet-390	92	41	transport	transport	NOUN
admet-390	92	42	of	of	ADP
admet-390	92	43	rhodamine	rhodamine	NOUN
admet-390	92	44	123	123	NUM
admet-390	92	45	and	and	CCONJ
admet-390	92	46	itraconazole	itraconazole	NOUN
admet-390	92	47	in	in	ADP
admet-390	92	48	the	the	DET
admet-390	92	49	murine	murine	ADJ
admet-390	92	50	skin	skin	NOUN
admet-390	92	51	[	[	X
admet-390	92	52	18	18	NUM
admet-390	92	53	]	]	PUNCT
admet-390	92	54	.	.	PUNCT
admet-390	93	1	the	the	DET
admet-390	93	2	penetration	penetration	NOUN
admet-390	93	3	was	be	AUX
admet-390	93	4	lower	low	ADJ
admet-390	93	5	in	in	ADP
admet-390	93	6	knockout	knockout	NOUN
admet-390	93	7	mice	mouse	NOUN
admet-390	93	8	(	(	PUNCT
admet-390	93	9	mdr1a/1b-/-	mdr1a/1b-/-	PROPN
admet-390	93	10	)	)	PUNCT
admet-390	93	11	than	than	ADP
admet-390	93	12	in	in	ADP
admet-390	93	13	wild	wild	ADJ
admet-390	93	14	-	-	PUNCT
admet-390	93	15	type	type	NOUN
admet-390	93	16	mice	mouse	NOUN
admet-390	93	17	,	,	PUNCT
admet-390	93	18	and	and	CCONJ
admet-390	93	19	propranolol	propranolol	PROPN
admet-390	93	20	,	,	PUNCT
admet-390	93	21	a	a	DET
admet-390	93	22	p	p	NOUN
admet-390	93	23	-	-	PUNCT
admet-390	93	24	gp	gp	NOUN
admet-390	93	25	inhibitor	inhibitor	NOUN
admet-390	93	26	,	,	PUNCT
admet-390	93	27	decreased	decrease	VERB
admet-390	93	28	the	the	DET
admet-390	93	29	concentration	concentration	NOUN
admet-390	93	30	of	of	ADP
admet-390	93	31	itraconazole	itraconazole	NOUN
admet-390	93	32	in	in	ADP
admet-390	93	33	the	the	DET
admet-390	93	34	skin	skin	NOUN
admet-390	93	35	of	of	ADP
admet-390	93	36	wild	wild	ADJ
admet-390	93	37	-	-	PUNCT
admet-390	93	38	type	type	NOUN
admet-390	93	39	mice	mouse	NOUN
admet-390	93	40	but	but	CCONJ
admet-390	93	41	not	not	PART
admet-390	93	42	in	in	ADP
admet-390	93	43	gene	gene	NOUN
admet-390	93	44	knockout	knockout	NOUN
admet-390	93	45	mice	mouse	NOUN
admet-390	93	46	[	[	X
admet-390	93	47	18	18	NUM
admet-390	93	48	]	]	PUNCT
admet-390	93	49	.	.	PUNCT
admet-390	94	1	this	this	DET
admet-390	94	2	absorptive	absorptive	ADJ
admet-390	94	3	function	function	NOUN
admet-390	94	4	was	be	AUX
admet-390	94	5	confirmed	confirm	VERB
admet-390	94	6	with	with	ADP
admet-390	94	7	flurbiprofen	flurbiprofen	NOUN
admet-390	94	8	and	and	CCONJ
admet-390	94	9	indomethacin	indomethacin	VERB
admet-390	94	10	[	[	PUNCT
admet-390	94	11	17	17	NUM
admet-390	94	12	]	]	PUNCT
admet-390	94	13	.	.	PUNCT
admet-390	95	1	recently	recently	ADV
admet-390	95	2	p	p	X
admet-390	95	3	-	-	PUNCT
admet-390	95	4	gp	gp	NOUN
admet-390	95	5	in	in	ADP
admet-390	95	6	skin	skin	NOUN
admet-390	95	7	was	be	AUX
admet-390	95	8	found	find	VERB
admet-390	95	9	to	to	PART
admet-390	95	10	contribute	contribute	VERB
admet-390	95	11	to	to	ADP
admet-390	95	12	the	the	DET
admet-390	95	13	transdermal	transdermal	ADJ
admet-390	95	14	absorption	absorption	NOUN
admet-390	95	15	of	of	ADP
admet-390	95	16	topical	topical	ADJ
admet-390	95	17	corticoids	corticoid	NOUN
admet-390	95	18	and	and	CCONJ
admet-390	95	19	ingenol-3	ingenol-3	NOUN
admet-390	95	20	-	-	PUNCT
admet-390	95	21	angelate	angelate	NOUN
admet-390	95	22	[	[	X
admet-390	95	23	29	29	NUM
admet-390	95	24	,	,	PUNCT
admet-390	95	25	30	30	NUM
admet-390	95	26	]	]	PUNCT
admet-390	95	27	.	.	PUNCT
admet-390	96	1	on	on	ADP
admet-390	96	2	the	the	DET
admet-390	96	3	other	other	ADJ
admet-390	96	4	hand	hand	NOUN
admet-390	96	5	,	,	PUNCT
admet-390	96	6	bcrp	bcrp	PROPN
admet-390	96	7	was	be	AUX
admet-390	96	8	shown	show	VERB
admet-390	96	9	to	to	PART
admet-390	96	10	contribute	contribute	VERB
admet-390	96	11	to	to	ADP
admet-390	96	12	the	the	DET
admet-390	96	13	transdermal	transdermal	ADJ
admet-390	96	14	transport	transport	NOUN
admet-390	96	15	of	of	ADP
admet-390	96	16	rhodamine	rhodamine	NOUN
admet-390	96	17	123	123	NUM
admet-390	96	18	,	,	PUNCT
admet-390	96	19	a	a	DET
admet-390	96	20	substrate	substrate	NOUN
admet-390	96	21	of	of	ADP
admet-390	96	22	p	p	NOUN
admet-390	96	23	-	-	PUNCT
admet-390	96	24	gp	gp	NOUN
admet-390	96	25	/	/	SYM
admet-390	96	26	mdr1	mdr1	PROPN
admet-390	97	1	[	[	X
admet-390	97	2	22	22	NUM
admet-390	97	3	]	]	PUNCT
admet-390	97	4	.	.	PUNCT
admet-390	98	1	there	there	PRON
admet-390	98	2	was	be	VERB
admet-390	98	3	still	still	ADV
admet-390	98	4	the	the	DET
admet-390	98	5	possibility	possibility	NOUN
admet-390	98	6	that	that	SCONJ
admet-390	98	7	abc	abc	PROPN
admet-390	98	8	transporters	transporter	NOUN
admet-390	98	9	(	(	PUNCT
admet-390	98	10	other	other	ADJ
admet-390	98	11	than	than	ADP
admet-390	98	12	mdr1	mdr1	PROPN
admet-390	98	13	)	)	PUNCT
admet-390	98	14	expressed	express	VERB
admet-390	98	15	in	in	ADP
admet-390	98	16	the	the	DET
admet-390	98	17	skin	skin	NOUN
admet-390	98	18	might	might	AUX
admet-390	98	19	play	play	VERB
admet-390	98	20	a	a	DET
admet-390	98	21	role	role	NOUN
admet-390	98	22	to	to	PART
admet-390	98	23	prevent	prevent	VERB
admet-390	98	24	xenobiotics	xenobiotic	NOUN
admet-390	98	25	from	from	ADP
admet-390	98	26	entering	enter	VERB
admet-390	98	27	the	the	DET
admet-390	98	28	systemic	systemic	ADJ
admet-390	98	29	circulation	circulation	NOUN
admet-390	98	30	,	,	PUNCT
admet-390	98	31	however	however	ADV
admet-390	98	32	,	,	PUNCT
admet-390	98	33	[	[	X
admet-390	98	34	14c]-grepafloxacin	14c]-grepafloxacin	NUM
admet-390	98	35	was	be	AUX
admet-390	98	36	shown	show	VERB
admet-390	98	37	to	to	PART
admet-390	98	38	be	be	AUX
admet-390	98	39	transported	transport	VERB
admet-390	98	40	in	in	ADP
admet-390	98	41	mouse	mouse	NOUN
admet-390	98	42	from	from	ADP
admet-390	98	43	the	the	DET
admet-390	98	44	skin	skin	NOUN
admet-390	98	45	back	back	ADV
admet-390	98	46	to	to	ADP
admet-390	98	47	the	the	DET
admet-390	98	48	blood	blood	NOUN
admet-390	98	49	[	[	X
admet-390	98	50	31	31	NUM
admet-390	98	51	]	]	PUNCT
admet-390	98	52	.	.	PUNCT
admet-390	99	1	in	in	ADP
admet-390	99	2	another	another	DET
admet-390	99	3	study	study	NOUN
admet-390	99	4	[	[	X
admet-390	99	5	20	20	NUM
admet-390	99	6	]	]	PUNCT
admet-390	99	7	,	,	PUNCT
admet-390	99	8	skin	skin	NOUN
admet-390	99	9	absorption	absorption	NOUN
admet-390	99	10	of	of	ADP
admet-390	99	11	rhodamine	rhodamine	NOUN
admet-390	99	12	123	123	NUM
admet-390	99	13	and	and	CCONJ
admet-390	99	14	vinblastine	vinblastine	NOUN
admet-390	99	15	were	be	AUX
admet-390	99	16	significantly	significantly	ADV
admet-390	99	17	reduced	reduce	VERB
admet-390	99	18	in	in	ADP
admet-390	99	19	ex	ex	PRON
admet-390	99	20	vivo	vivo	ADJ
admet-390	99	21	human	human	ADJ
admet-390	99	22	skin	skin	NOUN
admet-390	99	23	by	by	ADP
admet-390	99	24	verapamil	verapamil	NOUN
admet-390	99	25	,	,	PUNCT
admet-390	99	26	an	an	DET
admet-390	99	27	inhibitor	inhibitor	NOUN
admet-390	99	28	of	of	ADP
admet-390	99	29	mrp1	mrp1	NOUN
admet-390	99	30	[	[	X
admet-390	99	31	20	20	NUM
admet-390	99	32	]	]	PUNCT
admet-390	99	33	.	.	PUNCT
admet-390	100	1	moreover	moreover	ADV
admet-390	100	2	,	,	PUNCT
admet-390	100	3	mrp1	mrp1	PROPN
admet-390	100	4	was	be	AUX
admet-390	100	5	also	also	ADV
admet-390	100	6	found	find	VERB
admet-390	100	7	to	to	PART
admet-390	100	8	actively	actively	ADV
admet-390	100	9	reduce	reduce	VERB
admet-390	100	10	the	the	DET
admet-390	100	11	accumulation	accumulation	NOUN
admet-390	100	12	of	of	ADP
admet-390	100	13	substrates	substrate	NOUN
admet-390	100	14	within	within	ADP
admet-390	100	15	the	the	DET
admet-390	100	16	hair	hair	NOUN
admet-390	100	17	follicle	follicle	NOUN
admet-390	100	18	[	[	X
admet-390	100	19	19	19	NUM
admet-390	100	20	]	]	PUNCT
admet-390	100	21	.	.	PUNCT
admet-390	101	1	mdr1	mdr1	PROPN
admet-390	101	2	/	/	SYM
admet-390	101	3	p	p	NOUN
admet-390	101	4	-	-	PUNCT
admet-390	101	5	gp	gp	NOUN
admet-390	101	6	,	,	PUNCT
admet-390	101	7	mrp1	mrp1	NOUN
admet-390	101	8	and	and	CCONJ
admet-390	101	9	bcrp	bcrp	PROPN
admet-390	101	10	facilitate	facilitate	VERB
admet-390	101	11	the	the	DET
admet-390	101	12	flux	flux	NOUN
admet-390	101	13	of	of	ADP
admet-390	101	14	substrates	substrate	NOUN
admet-390	101	15	towards	towards	ADP
admet-390	101	16	the	the	DET
admet-390	101	17	inner	inner	ADJ
admet-390	101	18	layers	layer	NOUN
admet-390	101	19	of	of	ADP
admet-390	101	20	the	the	DET
admet-390	101	21	skin	skin	NOUN
admet-390	101	22	and	and	CCONJ
admet-390	101	23	not	not	PART
admet-390	101	24	the	the	DET
admet-390	101	25	reverse	reverse	NOUN
admet-390	101	26	.	.	PUNCT
admet-390	102	1	so	so	ADV
admet-390	102	2	the	the	DET
admet-390	102	3	simple	simple	ADJ
admet-390	102	4	concept	concept	NOUN
admet-390	102	5	of	of	ADP
admet-390	102	6	the	the	DET
admet-390	102	7	skin	skin	NOUN
admet-390	102	8	being	be	AUX
admet-390	102	9	a	a	DET
admet-390	102	10	barrier	barrier	NOUN
admet-390	102	11	preventing	prevent	VERB
admet-390	102	12	the	the	DET
admet-390	102	13	organ	organ	NOUN
admet-390	102	14	from	from	ADP
admet-390	102	15	the	the	DET
admet-390	102	16	environment	environment	NOUN
admet-390	102	17	is	be	AUX
admet-390	102	18	clearly	clearly	ADV
admet-390	102	19	not	not	PART
admet-390	102	20	entirely	entirely	ADV
admet-390	102	21	valid	valid	ADJ
admet-390	102	22	.	.	PUNCT
admet-390	103	1	the	the	DET
admet-390	103	2	exact	exact	ADJ
admet-390	103	3	and	and	CCONJ
admet-390	103	4	final	final	ADJ
admet-390	103	5	function	function	NOUN
admet-390	103	6	of	of	ADP
admet-390	103	7	these	these	DET
admet-390	103	8	transporters	transporter	NOUN
admet-390	103	9	is	be	AUX
admet-390	103	10	still	still	ADV
admet-390	103	11	a	a	DET
admet-390	103	12	matter	matter	NOUN
admet-390	103	13	of	of	ADP
admet-390	103	14	conjecture	conjecture	NOUN
admet-390	103	15	.	.	PUNCT
admet-390	104	1	these	these	DET
admet-390	104	2	early	early	ADJ
admet-390	104	3	studies	study	NOUN
admet-390	104	4	all	all	PRON
admet-390	104	5	point	point	VERB
admet-390	104	6	out	out	ADP
admet-390	104	7	to	to	ADP
admet-390	104	8	a	a	DET
admet-390	104	9	higher	high	ADJ
admet-390	104	10	concentration	concentration	NOUN
admet-390	104	11	of	of	ADP
admet-390	104	12	these	these	DET
admet-390	104	13	transporters	transporter	NOUN
admet-390	104	14	around	around	ADP
admet-390	104	15	the	the	DET
admet-390	104	16	sweat	sweat	NOUN
admet-390	104	17	gland	gland	NOUN
admet-390	104	18	and	and	CCONJ
admet-390	104	19	the	the	DET
admet-390	104	20	hair	hair	NOUN
admet-390	104	21	follicle	follicle	VERB
admet-390	104	22	.	.	PUNCT
admet-390	105	1	the	the	DET
admet-390	105	2	expression	expression	NOUN
admet-390	105	3	density	density	NOUN
admet-390	105	4	of	of	ADP
admet-390	105	5	these	these	DET
admet-390	105	6	transporters	transporter	NOUN
admet-390	105	7	varied	varied	ADJ
admet-390	105	8	with	with	ADP
admet-390	105	9	the	the	DET
admet-390	105	10	transporter	transporter	NOUN
admet-390	105	11	being	be	AUX
admet-390	105	12	rather	rather	ADV
admet-390	105	13	uniformly	uniformly	ADV
admet-390	105	14	expressed	express	VERB
admet-390	105	15	for	for	SCONJ
admet-390	105	16	abcb1	abcb1	NOUN
admet-390	105	17	to	to	PART
admet-390	105	18	specifically	specifically	ADV
admet-390	105	19	expressed	express	VERB
admet-390	105	20	in	in	ADP
admet-390	105	21	the	the	DET
admet-390	105	22	sweat	sweat	NOUN
admet-390	105	23	gland	gland	NOUN
admet-390	105	24	and	and	CCONJ
admet-390	105	25	the	the	DET
admet-390	105	26	dermal	dermal	ADJ
admet-390	105	27	papilla	papilla	NOUN
admet-390	105	28	for	for	ADP
admet-390	105	29	abcg2	abcg2	NOUN
admet-390	106	1	[	[	X
admet-390	106	2	19	19	NUM
admet-390	106	3	]	]	PUNCT
admet-390	106	4	.	.	PUNCT
admet-390	107	1	even	even	ADV
admet-390	107	2	though	though	SCONJ
admet-390	107	3	the	the	DET
admet-390	107	4	function	function	NOUN
admet-390	107	5	of	of	ADP
admet-390	107	6	this	this	DET
admet-390	107	7	differential	differential	ADJ
admet-390	107	8	expression	expression	NOUN
admet-390	107	9	has	have	VERB
admet-390	107	10	yet	yet	ADV
admet-390	107	11	to	to	PART
admet-390	107	12	be	be	AUX
admet-390	107	13	unravelled	unravel	VERB
admet-390	107	14	,	,	PUNCT
admet-390	107	15	it	it	PRON
admet-390	107	16	is	be	AUX
admet-390	107	17	admet	admet	PROPN
admet-390	107	18	&	&	CCONJ
admet-390	107	19	dmpk	dmpk	PROPN
admet-390	107	20	5(2	5(2	NUM
admet-390	107	21	)	)	PUNCT
admet-390	107	22	(	(	PUNCT
admet-390	107	23	2017	2017	NUM
admet-390	107	24	)	)	PUNCT
admet-390	107	25	75	75	NUM
admet-390	107	26	-	-	SYM
admet-390	107	27	84	84	NUM
admet-390	107	28	expression	expression	NOUN
admet-390	107	29	of	of	ADP
admet-390	107	30	drug	drug	NOUN
admet-390	107	31	transporters	transporter	NOUN
admet-390	107	32	in	in	ADP
admet-390	107	33	the	the	DET
admet-390	107	34	human	human	ADJ
admet-390	107	35	skin	skin	NOUN
admet-390	107	36	doi	doi	NOUN
admet-390	107	37	:	:	PUNCT
admet-390	107	38	10.5599	10.5599	NUM
admet-390	107	39	/	/	SYM
admet-390	107	40	admet.5.2.390	admet.5.2.390	NUM
admet-390	107	41	81	81	NUM
admet-390	107	42	conceivable	conceivable	ADJ
admet-390	107	43	that	that	SCONJ
admet-390	107	44	mrp1	mrp1	NOUN
admet-390	107	45	provides	provide	VERB
admet-390	107	46	protection	protection	NOUN
admet-390	107	47	against	against	ADP
admet-390	107	48	both	both	CCONJ
admet-390	107	49	xenobiotic	xenobiotic	ADJ
admet-390	107	50	and	and	CCONJ
admet-390	107	51	oxidative	oxidative	ADJ
admet-390	107	52	insult	insult	NOUN
admet-390	107	53	in	in	ADP
admet-390	107	54	the	the	DET
admet-390	107	55	hair	hair	NOUN
admet-390	107	56	follicle	follicle	VERB
admet-390	107	57	thereby	thereby	ADV
admet-390	107	58	preventing	prevent	VERB
admet-390	107	59	melanocyte	melanocyte	NOUN
admet-390	107	60	depletion	depletion	NOUN
admet-390	107	61	and	and	CCONJ
admet-390	107	62	hair	hair	NOUN
admet-390	107	63	greying	grey	VERB
admet-390	107	64	[	[	X
admet-390	107	65	19	19	NUM
admet-390	107	66	]	]	PUNCT
admet-390	107	67	,	,	PUNCT
admet-390	107	68	and	and	CCONJ
admet-390	107	69	that	that	SCONJ
admet-390	107	70	bcrp	bcrp	ADV
admet-390	107	71	may	may	AUX
admet-390	107	72	protect	protect	VERB
admet-390	107	73	the	the	DET
admet-390	107	74	hair	hair	NOUN
admet-390	107	75	follicle	follicle	VERB
admet-390	107	76	against	against	ADP
admet-390	107	77	cytotoxic	cytotoxic	ADJ
admet-390	107	78	insults	insult	NOUN
admet-390	107	79	from	from	ADP
admet-390	107	80	chemotherapeutics	chemotherapeutic	NOUN
admet-390	107	81	,	,	PUNCT
admet-390	107	82	thereby	thereby	ADV
admet-390	107	83	preventing	prevent	VERB
admet-390	107	84	or	or	CCONJ
admet-390	107	85	reducing	reduce	VERB
admet-390	107	86	the	the	DET
admet-390	107	87	associated	associated	ADJ
admet-390	107	88	alopecia	alopecia	NOUN
admet-390	107	89	[	[	X
admet-390	107	90	19	19	NUM
admet-390	107	91	]	]	PUNCT
admet-390	107	92	.	.	PUNCT
admet-390	108	1	there	there	PRON
admet-390	108	2	are	be	VERB
admet-390	108	3	fewer	few	ADJ
admet-390	108	4	studies	study	NOUN
admet-390	108	5	about	about	ADP
admet-390	108	6	slc	slc	PROPN
admet-390	108	7	transporters	transporter	NOUN
admet-390	108	8	in	in	ADP
admet-390	108	9	the	the	DET
admet-390	108	10	skin	skin	NOUN
admet-390	108	11	,	,	PUNCT
admet-390	108	12	but	but	CCONJ
admet-390	108	13	the	the	DET
admet-390	108	14	uptake	uptake	NOUN
admet-390	108	15	of	of	ADP
admet-390	108	16	large	large	ADJ
admet-390	108	17	organic	organic	ADJ
admet-390	108	18	cations	cation	NOUN
admet-390	108	19	such	such	ADJ
admet-390	108	20	as	as	ADP
admet-390	108	21	drugs	drug	NOUN
admet-390	108	22	in	in	ADP
admet-390	108	23	keratinocytes	keratinocyte	NOUN
admet-390	108	24	was	be	AUX
admet-390	108	25	shown	show	VERB
admet-390	108	26	to	to	PART
admet-390	108	27	be	be	AUX
admet-390	108	28	an	an	DET
admet-390	108	29	active	active	ADJ
admet-390	108	30	process	process	NOUN
admet-390	108	31	mediated	mediate	VERB
admet-390	108	32	by	by	ADP
admet-390	108	33	members	member	NOUN
admet-390	108	34	of	of	ADP
admet-390	108	35	the	the	DET
admet-390	108	36	slc	slc	PROPN
admet-390	108	37	transporter	transporter	NOUN
admet-390	108	38	family	family	NOUN
admet-390	108	39	,	,	PUNCT
admet-390	108	40	which	which	PRON
admet-390	108	41	can	can	AUX
admet-390	108	42	be	be	AUX
admet-390	108	43	modulated	modulate	VERB
admet-390	108	44	by	by	ADP
admet-390	108	45	specific	specific	ADJ
admet-390	108	46	competitors	competitor	NOUN
admet-390	108	47	in	in	ADP
admet-390	108	48	vivo	vivo	NOUN
admet-390	108	49	[	[	X
admet-390	108	50	9	9	NUM
admet-390	108	51	]	]	PUNCT
admet-390	108	52	.	.	PUNCT
admet-390	109	1	overall	overall	ADV
admet-390	109	2	,	,	PUNCT
admet-390	109	3	the	the	DET
admet-390	109	4	real	real	ADJ
admet-390	109	5	function	function	NOUN
admet-390	109	6	of	of	ADP
admet-390	109	7	transporters	transporter	NOUN
admet-390	109	8	in	in	ADP
admet-390	109	9	the	the	DET
admet-390	109	10	skin	skin	NOUN
admet-390	109	11	is	be	AUX
admet-390	109	12	still	still	ADV
admet-390	109	13	largely	largely	ADV
admet-390	109	14	unknown	unknown	ADJ
admet-390	109	15	.	.	PUNCT
admet-390	110	1	implication	implication	NOUN
admet-390	110	2	for	for	ADP
admet-390	110	3	drug	drug	NOUN
admet-390	110	4	development	development	NOUN
admet-390	110	5	absorption	absorption	NOUN
admet-390	110	6	through	through	ADP
admet-390	110	7	the	the	DET
admet-390	110	8	skin	skin	NOUN
admet-390	110	9	is	be	AUX
admet-390	110	10	thought	think	VERB
admet-390	110	11	to	to	PART
admet-390	110	12	be	be	AUX
admet-390	110	13	largely	largely	ADV
admet-390	110	14	dependent	dependent	ADJ
admet-390	110	15	upon	upon	SCONJ
admet-390	110	16	the	the	DET
admet-390	110	17	physicochemical	physicochemical	ADJ
admet-390	110	18	properties	property	NOUN
admet-390	110	19	of	of	ADP
admet-390	110	20	the	the	DET
admet-390	110	21	drug	drug	NOUN
admet-390	110	22	and	and	CCONJ
admet-390	110	23	to	to	PART
admet-390	110	24	follow	follow	VERB
admet-390	110	25	the	the	DET
admet-390	110	26	concentration	concentration	NOUN
admet-390	110	27	gradient	gradient	NOUN
admet-390	110	28	across	across	ADP
admet-390	110	29	the	the	DET
admet-390	110	30	skin	skin	NOUN
admet-390	110	31	according	accord	VERB
admet-390	110	32	the	the	DET
admet-390	110	33	fick	fick	NOUN
admet-390	110	34	’s	’s	PART
admet-390	110	35	first	first	ADJ
admet-390	110	36	law	law	NOUN
admet-390	110	37	.	.	PUNCT
admet-390	111	1	this	this	PRON
admet-390	111	2	is	be	AUX
admet-390	111	3	a	a	DET
admet-390	111	4	rough	rough	ADJ
admet-390	111	5	approximation	approximation	NOUN
admet-390	111	6	as	as	ADP
admet-390	111	7	the	the	DET
admet-390	111	8	pharmacokinetics	pharmacokinetic	NOUN
admet-390	111	9	of	of	ADP
admet-390	111	10	drug	drug	NOUN
admet-390	111	11	permeation	permeation	NOUN
admet-390	111	12	is	be	AUX
admet-390	111	13	actually	actually	ADV
admet-390	111	14	far	far	ADV
admet-390	111	15	more	more	ADV
admet-390	111	16	complex	complex	ADJ
admet-390	111	17	and	and	CCONJ
admet-390	111	18	should	should	AUX
admet-390	111	19	be	be	AUX
admet-390	111	20	modelized	modelize	VERB
admet-390	111	21	by	by	ADP
admet-390	111	22	a	a	DET
admet-390	111	23	multicompartmental	multicompartmental	ADJ
admet-390	111	24	system	system	NOUN
admet-390	111	25	[	[	X
admet-390	111	26	32	32	NUM
admet-390	111	27	]	]	PUNCT
admet-390	111	28	.	.	PUNCT
admet-390	112	1	the	the	DET
admet-390	112	2	presence	presence	NOUN
admet-390	112	3	of	of	ADP
admet-390	112	4	transporters	transporter	NOUN
admet-390	112	5	would	would	AUX
admet-390	112	6	either	either	CCONJ
admet-390	112	7	facilitate	facilitate	VERB
admet-390	112	8	or	or	CCONJ
admet-390	112	9	hamper	hamper	VERB
admet-390	112	10	the	the	DET
admet-390	112	11	topical	topical	ADJ
admet-390	112	12	absorption	absorption	NOUN
admet-390	112	13	depending	depend	VERB
admet-390	112	14	upon	upon	SCONJ
admet-390	112	15	the	the	DET
admet-390	112	16	direction	direction	NOUN
admet-390	112	17	of	of	ADP
admet-390	112	18	the	the	DET
admet-390	112	19	flux	flux	NOUN
admet-390	112	20	.	.	PUNCT
admet-390	113	1	furthermore	furthermore	ADV
admet-390	113	2	,	,	PUNCT
admet-390	113	3	potential	potential	ADJ
admet-390	113	4	drug	drug	NOUN
admet-390	113	5	-	-	PUNCT
admet-390	113	6	drug	drug	NOUN
admet-390	113	7	interactions	interaction	NOUN
admet-390	113	8	would	would	AUX
admet-390	113	9	modulate	modulate	VERB
admet-390	113	10	the	the	DET
admet-390	113	11	permeation	permeation	NOUN
admet-390	113	12	process	process	NOUN
admet-390	113	13	and	and	CCONJ
admet-390	113	14	could	could	AUX
admet-390	113	15	either	either	CCONJ
admet-390	113	16	induce	induce	VERB
admet-390	113	17	or	or	CCONJ
admet-390	113	18	inhibit	inhibit	VERB
admet-390	113	19	the	the	DET
admet-390	113	20	flux	flux	NOUN
admet-390	113	21	through	through	ADP
admet-390	113	22	a	a	DET
admet-390	113	23	skin	skin	NOUN
admet-390	113	24	layer	layer	NOUN
admet-390	113	25	creating	create	VERB
admet-390	113	26	a	a	DET
admet-390	113	27	local	local	ADJ
admet-390	113	28	zone	zone	NOUN
admet-390	113	29	of	of	ADP
admet-390	113	30	abnormal	abnormal	ADJ
admet-390	113	31	concentrations	concentration	NOUN
admet-390	113	32	.	.	PUNCT
admet-390	114	1	most	most	ADJ
admet-390	114	2	drugs	drug	NOUN
admet-390	114	3	are	be	AUX
admet-390	114	4	likely	likely	ADJ
admet-390	114	5	not	not	PART
admet-390	114	6	to	to	PART
admet-390	114	7	be	be	AUX
admet-390	114	8	affected	affect	VERB
admet-390	114	9	,	,	PUNCT
admet-390	114	10	but	but	CCONJ
admet-390	114	11	in	in	ADP
admet-390	114	12	a	a	DET
admet-390	114	13	few	few	ADJ
admet-390	114	14	instances	instance	NOUN
admet-390	114	15	we	we	PRON
admet-390	114	16	may	may	AUX
admet-390	114	17	get	get	VERB
admet-390	114	18	a	a	DET
admet-390	114	19	clinically	clinically	ADV
admet-390	114	20	significant	significant	ADJ
admet-390	114	21	effect	effect	NOUN
admet-390	114	22	.	.	PUNCT
admet-390	115	1	there	there	PRON
admet-390	115	2	is	be	VERB
admet-390	115	3	now	now	ADV
admet-390	115	4	evidence	evidence	NOUN
admet-390	115	5	that	that	SCONJ
admet-390	115	6	substrates	substrate	NOUN
admet-390	115	7	of	of	ADP
admet-390	115	8	p	p	NOUN
admet-390	115	9	-	-	PUNCT
admet-390	115	10	gp	gp	NOUN
admet-390	115	11	have	have	AUX
admet-390	115	12	a	a	DET
admet-390	115	13	facilitated	facilitate	VERB
admet-390	115	14	absorption	absorption	NOUN
admet-390	115	15	through	through	ADP
admet-390	115	16	the	the	DET
admet-390	115	17	skin	skin	NOUN
admet-390	115	18	.	.	PUNCT
admet-390	116	1	we	we	PRON
admet-390	116	2	do	do	AUX
admet-390	116	3	not	not	PART
admet-390	116	4	know	know	VERB
admet-390	116	5	if	if	SCONJ
admet-390	116	6	these	these	DET
admet-390	116	7	theoretical	theoretical	ADJ
admet-390	116	8	considerations	consideration	NOUN
admet-390	116	9	actually	actually	ADV
admet-390	116	10	play	play	VERB
admet-390	116	11	a	a	DET
admet-390	116	12	clinical	clinical	ADJ
admet-390	116	13	role	role	NOUN
admet-390	116	14	in	in	ADP
admet-390	116	15	the	the	DET
admet-390	116	16	skin	skin	NOUN
admet-390	116	17	permeation	permeation	NOUN
admet-390	116	18	of	of	ADP
admet-390	116	19	drugs	drug	NOUN
admet-390	116	20	,	,	PUNCT
admet-390	116	21	but	but	CCONJ
admet-390	116	22	in	in	ADP
admet-390	116	23	theory	theory	NOUN
admet-390	116	24	we	we	PRON
admet-390	116	25	could	could	AUX
admet-390	116	26	modulate	modulate	VERB
admet-390	116	27	the	the	DET
admet-390	116	28	flux	flux	NOUN
admet-390	116	29	to	to	PART
admet-390	116	30	either	either	CCONJ
admet-390	116	31	improve	improve	VERB
admet-390	116	32	or	or	CCONJ
admet-390	116	33	decrease	decrease	VERB
admet-390	116	34	the	the	DET
admet-390	116	35	systemic	systemic	ADJ
admet-390	116	36	exposure	exposure	NOUN
admet-390	116	37	and	and	CCONJ
admet-390	116	38	to	to	PART
admet-390	116	39	increase	increase	VERB
admet-390	116	40	or	or	CCONJ
admet-390	116	41	decrease	decrease	VERB
admet-390	116	42	the	the	DET
admet-390	116	43	skin	skin	NOUN
admet-390	116	44	concentrations	concentration	NOUN
admet-390	116	45	.	.	PUNCT
admet-390	117	1	in	in	ADP
admet-390	117	2	theory	theory	NOUN
admet-390	117	3	,	,	PUNCT
admet-390	117	4	at	at	ADP
admet-390	117	5	least	least	ADJ
admet-390	117	6	,	,	PUNCT
admet-390	117	7	inhibitors	inhibitor	NOUN
admet-390	117	8	of	of	ADP
admet-390	117	9	p	p	NOUN
admet-390	117	10	-	-	PUNCT
admet-390	117	11	gp	gp	NOUN
admet-390	117	12	would	would	AUX
admet-390	117	13	reduce	reduce	VERB
admet-390	117	14	the	the	DET
admet-390	117	15	systemic	systemic	ADJ
admet-390	117	16	exposure	exposure	NOUN
admet-390	117	17	of	of	ADP
admet-390	117	18	corticoids	corticoid	NOUN
admet-390	117	19	[	[	X
admet-390	117	20	29	29	NUM
admet-390	117	21	]	]	PUNCT
admet-390	117	22	while	while	SCONJ
admet-390	117	23	inducers	inducer	NOUN
admet-390	117	24	might	might	AUX
admet-390	117	25	improve	improve	VERB
admet-390	117	26	the	the	DET
admet-390	117	27	delivery	delivery	NOUN
admet-390	117	28	of	of	ADP
admet-390	117	29	chemotherapeutic	chemotherapeutic	ADJ
admet-390	117	30	agents	agent	NOUN
admet-390	117	31	into	into	ADP
admet-390	117	32	the	the	DET
admet-390	117	33	skin	skin	NOUN
admet-390	117	34	.	.	PUNCT
admet-390	118	1	we	we	PRON
admet-390	118	2	are	be	AUX
admet-390	118	3	at	at	ADP
admet-390	118	4	the	the	DET
admet-390	118	5	early	early	ADJ
admet-390	118	6	stage	stage	NOUN
admet-390	118	7	of	of	ADP
admet-390	118	8	transporter	transporter	NOUN
admet-390	118	9	research	research	NOUN
admet-390	118	10	in	in	ADP
admet-390	118	11	the	the	DET
admet-390	118	12	skin	skin	NOUN
admet-390	118	13	,	,	PUNCT
admet-390	118	14	and	and	CCONJ
admet-390	118	15	we	we	PRON
admet-390	118	16	have	have	VERB
admet-390	118	17	to	to	PART
admet-390	118	18	obtain	obtain	VERB
admet-390	118	19	more	more	ADJ
admet-390	118	20	data	datum	NOUN
admet-390	118	21	about	about	ADP
admet-390	118	22	the	the	DET
admet-390	118	23	quantitation	quantitation	NOUN
admet-390	118	24	of	of	ADP
admet-390	118	25	functional	functional	ADJ
admet-390	118	26	transporters	transporter	NOUN
admet-390	118	27	and	and	CCONJ
admet-390	118	28	not	not	PART
admet-390	118	29	just	just	ADV
admet-390	118	30	looking	look	VERB
admet-390	118	31	at	at	ADP
admet-390	118	32	the	the	DET
admet-390	118	33	mrna	mrna	PROPN
admet-390	118	34	expression	expression	NOUN
admet-390	118	35	.	.	PUNCT
admet-390	119	1	the	the	DET
admet-390	119	2	interindividual	interindividual	ADJ
admet-390	119	3	variability	variability	NOUN
admet-390	119	4	in	in	ADP
admet-390	119	5	the	the	DET
admet-390	119	6	expression	expression	NOUN
admet-390	119	7	and	and	CCONJ
admet-390	119	8	activity	activity	NOUN
admet-390	119	9	of	of	ADP
admet-390	119	10	transporters	transporter	NOUN
admet-390	119	11	is	be	AUX
admet-390	119	12	another	another	DET
admet-390	119	13	point	point	NOUN
admet-390	119	14	to	to	PART
admet-390	119	15	clarify	clarify	VERB
admet-390	119	16	.	.	PUNCT
admet-390	120	1	do	do	AUX
admet-390	120	2	we	we	PRON
admet-390	120	3	have	have	VERB
admet-390	120	4	genetic	genetic	ADJ
admet-390	120	5	or	or	CCONJ
admet-390	120	6	disease	disease	NOUN
admet-390	120	7	-	-	PUNCT
admet-390	120	8	induced	induce	VERB
admet-390	120	9	effects	effect	NOUN
admet-390	120	10	in	in	ADP
admet-390	120	11	the	the	DET
admet-390	120	12	expression	expression	NOUN
admet-390	120	13	?	?	PUNCT
admet-390	121	1	so	so	ADV
admet-390	121	2	the	the	DET
admet-390	121	3	usual	usual	ADJ
admet-390	121	4	drug	drug	NOUN
admet-390	121	5	-	-	PUNCT
admet-390	121	6	drug	drug	NOUN
admet-390	121	7	interactions	interaction	NOUN
admet-390	121	8	regulatory	regulatory	ADJ
admet-390	121	9	guidances	guidance	NOUN
admet-390	121	10	for	for	ADP
admet-390	121	11	other	other	ADJ
admet-390	121	12	tissues	tissue	NOUN
admet-390	121	13	(	(	PUNCT
admet-390	121	14	liver	liver	NOUN
admet-390	121	15	,	,	PUNCT
admet-390	121	16	intestine	intestine	NOUN
admet-390	121	17	,	,	PUNCT
admet-390	121	18	kidney	kidney	NOUN
admet-390	121	19	…	…	PUNCT
admet-390	121	20	)	)	PUNCT
admet-390	122	1	[	[	X
admet-390	122	2	34	34	NUM
admet-390	122	3	,	,	PUNCT
admet-390	122	4	35	35	NUM
admet-390	122	5	]	]	PUNCT
admet-390	122	6	may	may	AUX
admet-390	122	7	not	not	PART
admet-390	122	8	apply	apply	VERB
admet-390	122	9	until	until	SCONJ
admet-390	122	10	more	more	ADJ
admet-390	122	11	data	datum	NOUN
admet-390	122	12	are	be	AUX
admet-390	122	13	obtained	obtain	VERB
admet-390	122	14	.	.	PUNCT
admet-390	123	1	several	several	ADJ
admet-390	123	2	studies	study	NOUN
admet-390	123	3	have	have	AUX
admet-390	123	4	pointed	point	VERB
admet-390	123	5	out	out	ADP
admet-390	123	6	the	the	DET
admet-390	123	7	unusually	unusually	ADV
admet-390	123	8	high	high	ADJ
admet-390	123	9	expression	expression	NOUN
admet-390	123	10	of	of	ADP
admet-390	123	11	transporters	transporter	NOUN
admet-390	123	12	around	around	ADP
admet-390	123	13	the	the	DET
admet-390	123	14	hair	hair	NOUN
admet-390	123	15	follicle	follicle	VERB
admet-390	123	16	and	and	CCONJ
admet-390	123	17	sweat	sweat	NOUN
admet-390	123	18	gland	gland	NOUN
admet-390	124	1	[	[	X
admet-390	124	2	19	19	NUM
admet-390	124	3	,	,	PUNCT
admet-390	124	4	20	20	NUM
admet-390	124	5	,	,	PUNCT
admet-390	124	6	22	22	NUM
admet-390	124	7	]	]	PUNCT
admet-390	124	8	.	.	PUNCT
admet-390	125	1	the	the	DET
admet-390	125	2	function	function	NOUN
admet-390	125	3	of	of	ADP
admet-390	125	4	these	these	DET
admet-390	125	5	transporters	transporter	NOUN
admet-390	125	6	is	be	AUX
admet-390	125	7	not	not	PART
admet-390	125	8	yet	yet	ADV
admet-390	125	9	clear	clear	ADJ
admet-390	125	10	,	,	PUNCT
admet-390	125	11	but	but	CCONJ
admet-390	125	12	more	more	ADJ
admet-390	125	13	research	research	NOUN
admet-390	125	14	is	be	AUX
admet-390	125	15	actively	actively	ADV
admet-390	125	16	needed	need	VERB
admet-390	125	17	in	in	ADP
admet-390	125	18	order	order	NOUN
admet-390	125	19	to	to	PART
admet-390	125	20	clarify	clarify	VERB
admet-390	125	21	the	the	DET
admet-390	125	22	potential	potential	ADJ
admet-390	125	23	role	role	NOUN
admet-390	125	24	in	in	ADP
admet-390	125	25	the	the	DET
admet-390	125	26	excretory	excretory	NOUN
admet-390	125	27	function	function	NOUN
admet-390	125	28	or	or	CCONJ
admet-390	125	29	the	the	DET
admet-390	125	30	protection	protection	NOUN
admet-390	125	31	of	of	ADP
admet-390	125	32	these	these	DET
admet-390	125	33	organelles	organelle	NOUN
admet-390	126	1	[	[	X
admet-390	126	2	19	19	NUM
admet-390	126	3	]	]	X
admet-390	126	4	,	,	PUNCT
admet-390	126	5	as	as	SCONJ
admet-390	126	6	this	this	PRON
admet-390	126	7	may	may	AUX
admet-390	126	8	have	have	VERB
admet-390	126	9	a	a	DET
admet-390	126	10	great	great	ADJ
admet-390	126	11	potential	potential	NOUN
admet-390	126	12	for	for	ADP
admet-390	126	13	intervention	intervention	NOUN
admet-390	126	14	.	.	PUNCT
admet-390	127	1	although	although	SCONJ
admet-390	127	2	mate	mate	NOUN
admet-390	127	3	transporters	transporter	NOUN
admet-390	127	4	belong	belong	VERB
admet-390	127	5	to	to	ADP
admet-390	127	6	slc	slc	PROPN
admet-390	127	7	family	family	NOUN
admet-390	127	8	,	,	PUNCT
admet-390	127	9	they	they	PRON
admet-390	127	10	are	be	AUX
admet-390	127	11	an	an	DET
admet-390	127	12	efflux	efflux	NOUN
admet-390	127	13	transporter	transporter	NOUN
admet-390	127	14	and	and	CCONJ
admet-390	127	15	play	play	VERB
admet-390	127	16	a	a	DET
admet-390	127	17	role	role	NOUN
admet-390	127	18	in	in	ADP
admet-390	127	19	renal	renal	ADJ
admet-390	127	20	and	and	CCONJ
admet-390	127	21	biliary	biliary	ADJ
admet-390	127	22	excretion	excretion	NOUN
admet-390	127	23	of	of	ADP
admet-390	127	24	endogenous	endogenous	ADJ
admet-390	127	25	and	and	CCONJ
admet-390	127	26	exogenous	exogenous	ADJ
admet-390	127	27	compounds	compound	NOUN
admet-390	127	28	including	include	VERB
admet-390	127	29	xenobiotics	xenobiotic	NOUN
admet-390	127	30	and	and	CCONJ
admet-390	127	31	drugs	drug	NOUN
admet-390	127	32	[	[	X
admet-390	127	33	36	36	NUM
admet-390	127	34	,	,	PUNCT
admet-390	127	35	37	37	NUM
admet-390	127	36	]	]	PUNCT
admet-390	127	37	.	.	PUNCT
admet-390	128	1	cis	cis	NOUN
admet-390	128	2	-	-	PUNCT
admet-390	128	3	inhibition	inhibition	NOUN
admet-390	128	4	studies	study	NOUN
admet-390	128	5	have	have	AUX
admet-390	128	6	suggested	suggest	VERB
admet-390	128	7	that	that	SCONJ
admet-390	128	8	mate	mate	NOUN
admet-390	128	9	transporters	transporter	NOUN
admet-390	128	10	may	may	AUX
admet-390	128	11	be	be	AUX
admet-390	128	12	involved	involve	VERB
admet-390	128	13	in	in	ADP
admet-390	128	14	the	the	DET
admet-390	128	15	transport	transport	NOUN
admet-390	128	16	of	of	ADP
admet-390	128	17	endogenous	endogenous	ADJ
admet-390	128	18	steroid	steroid	NOUN
admet-390	128	19	hormones	hormone	NOUN
admet-390	128	20	like	like	ADP
admet-390	128	21	testosterone	testosterone	NOUN
admet-390	129	1	[	[	X
admet-390	129	2	38	38	NUM
admet-390	129	3	,	,	PUNCT
admet-390	129	4	39	39	NUM
admet-390	129	5	]	]	PUNCT
admet-390	129	6	.	.	PUNCT
admet-390	130	1	skin	skin	NOUN
admet-390	130	2	is	be	AUX
admet-390	130	3	known	know	VERB
admet-390	130	4	as	as	ADP
admet-390	130	5	steroidogenic	steroidogenic	ADJ
admet-390	130	6	organ	organ	NOUN
admet-390	130	7	and	and	CCONJ
admet-390	130	8	skin	skin	NOUN
admet-390	130	9	cells	cell	NOUN
admet-390	130	10	produce	produce	VERB
admet-390	130	11	steroid	steroid	NOUN
admet-390	130	12	hormones	hormone	NOUN
admet-390	130	13	like	like	ADP
admet-390	130	14	testosterone	testosterone	NOUN
admet-390	131	1	[	[	X
admet-390	131	2	40	40	NUM
admet-390	131	3	]	]	PUNCT
admet-390	131	4	.	.	PUNCT
admet-390	132	1	we	we	PRON
admet-390	132	2	suppose	suppose	VERB
admet-390	132	3	that	that	SCONJ
admet-390	132	4	mate	mate	NOUN
admet-390	132	5	transporters	transporter	NOUN
admet-390	132	6	are	be	AUX
admet-390	132	7	responsible	responsible	ADJ
admet-390	132	8	for	for	ADP
admet-390	132	9	the	the	DET
admet-390	132	10	secretion	secretion	NOUN
admet-390	132	11	of	of	ADP
admet-390	132	12	steroid	steroid	NOUN
admet-390	132	13	hormones	hormone	NOUN
admet-390	132	14	through	through	ADP
admet-390	132	15	the	the	DET
admet-390	132	16	plasma	plasma	NOUN
admet-390	132	17	membrane	membrane	NOUN
admet-390	132	18	in	in	ADP
admet-390	132	19	the	the	DET
admet-390	132	20	skin	skin	NOUN
admet-390	132	21	.	.	PUNCT
admet-390	133	1	moreover	moreover	ADV
admet-390	133	2	,	,	PUNCT
admet-390	133	3	mate	mate	NOUN
admet-390	133	4	transporters	transporter	NOUN
admet-390	133	5	are	be	AUX
admet-390	133	6	down	down	ADV
admet-390	133	7	-	-	PUNCT
admet-390	133	8	regulated	regulate	VERB
admet-390	133	9	by	by	ADP
admet-390	133	10	rifampicin	rifampicin	VERB
admet-390	133	11	which	which	PRON
admet-390	133	12	suggests	suggest	VERB
admet-390	133	13	a	a	DET
admet-390	133	14	role	role	NOUN
admet-390	133	15	in	in	ADP
admet-390	133	16	drug	drug	NOUN
admet-390	133	17	-	-	PUNCT
admet-390	133	18	drug	drug	NOUN
admet-390	133	19	interactions	interaction	NOUN
admet-390	133	20	.	.	PUNCT
admet-390	134	1	of	of	ADP
admet-390	134	2	the	the	DET
admet-390	134	3	hypothesis	hypothesis	NOUN
admet-390	134	4	that	that	PRON
admet-390	134	5	mini	mini	ADJ
admet-390	134	6	pig	pig	NOUN
admet-390	134	7	studies	study	NOUN
admet-390	134	8	may	may	AUX
admet-390	134	9	better	well	ADV
admet-390	134	10	reflect	reflect	VERB
admet-390	134	11	human	human	ADJ
admet-390	134	12	drug	drug	NOUN
admet-390	134	13	-	-	PUNCT
admet-390	134	14	induced	induce	VERB
admet-390	134	15	toxicities	toxicity	NOUN
admet-390	134	16	than	than	ADP
admet-390	134	17	other	other	ADJ
admet-390	134	18	species	specie	NOUN
admet-390	134	19	,	,	PUNCT
admet-390	134	20	it	it	PRON
admet-390	134	21	is	be	AUX
admet-390	134	22	mandatory	mandatory	ADJ
admet-390	134	23	to	to	PART
admet-390	134	24	know	know	VERB
admet-390	134	25	why	why	SCONJ
admet-390	134	26	none	none	NOUN
admet-390	134	27	of	of	ADP
admet-390	134	28	slc	slc	PROPN
admet-390	134	29	transporters	transporter	NOUN
admet-390	134	30	is	be	AUX
admet-390	134	31	expressed	express	VERB
admet-390	134	32	in	in	ADP
admet-390	134	33	the	the	DET
admet-390	134	34	skin	skin	NOUN
admet-390	134	35	of	of	ADP
admet-390	134	36	göttingen	göttingen	PROPN
admet-390	134	37	mini	mini	ADJ
admet-390	134	38	pig	pig	NOUN
admet-390	134	39	.	.	PUNCT
admet-390	135	1	h.	h.	PROPN
admet-390	135	2	osman	osman	PROPN
admet-390	135	3	-	-	PUNCT
admet-390	135	4	ponchet	ponchet	NOUN
admet-390	135	5	et	et	PROPN
admet-390	135	6	al	al	PROPN
admet-390	135	7	.	.	PROPN
admet-390	135	8	admet	admet	PROPN
admet-390	135	9	&	&	CCONJ
admet-390	135	10	dmpk	dmpk	PROPN
admet-390	135	11	5(2	5(2	NUM
admet-390	135	12	)	)	PUNCT
admet-390	135	13	(	(	PUNCT
admet-390	135	14	2017	2017	NUM
admet-390	135	15	)	)	PUNCT
admet-390	135	16	75	75	NUM
admet-390	135	17	-	-	SYM
admet-390	135	18	84	84	NUM
admet-390	135	19	82	82	NUM
admet-390	135	20	one	one	NUM
admet-390	135	21	of	of	ADP
admet-390	135	22	the	the	DET
admet-390	135	23	limitations	limitation	NOUN
admet-390	135	24	of	of	ADP
admet-390	135	25	most	most	ADJ
admet-390	135	26	of	of	ADP
admet-390	135	27	these	these	DET
admet-390	135	28	studies	study	NOUN
admet-390	135	29	is	be	AUX
admet-390	135	30	that	that	SCONJ
admet-390	135	31	the	the	DET
admet-390	135	32	expression	expression	NOUN
admet-390	135	33	of	of	ADP
admet-390	135	34	transporters	transporter	NOUN
admet-390	135	35	has	have	AUX
admet-390	135	36	been	be	AUX
admet-390	135	37	compared	compare	VERB
admet-390	135	38	by	by	ADP
admet-390	135	39	quantifying	quantify	VERB
admet-390	135	40	the	the	DET
admet-390	135	41	expression	expression	NOUN
admet-390	135	42	of	of	ADP
admet-390	135	43	the	the	DET
admet-390	135	44	transporter	transporter	NOUN
admet-390	135	45	mrnas	mrna	NOUN
admet-390	135	46	.	.	PUNCT
admet-390	136	1	this	this	DET
admet-390	136	2	method	method	NOUN
admet-390	136	3	has	have	VERB
admet-390	136	4	its	its	PRON
admet-390	136	5	shortcomings	shortcoming	NOUN
admet-390	136	6	,	,	PUNCT
admet-390	136	7	as	as	ADP
admet-390	136	8	for	for	ADP
admet-390	136	9	transporters	transporter	NOUN
admet-390	136	10	,	,	PUNCT
admet-390	136	11	the	the	DET
admet-390	136	12	mrna	mrna	NOUN
admet-390	136	13	expression	expression	NOUN
admet-390	136	14	does	do	AUX
admet-390	136	15	not	not	PART
admet-390	136	16	correlate	correlate	VERB
admet-390	136	17	well	well	ADV
admet-390	136	18	with	with	ADP
admet-390	136	19	protein	protein	NOUN
admet-390	136	20	expression	expression	NOUN
admet-390	136	21	of	of	ADP
admet-390	136	22	transporters	transporter	NOUN
admet-390	136	23	and	and	CCONJ
admet-390	136	24	protein	protein	NOUN
admet-390	136	25	activity	activity	NOUN
admet-390	136	26	[	[	X
admet-390	136	27	41	41	NUM
admet-390	136	28	,	,	PUNCT
admet-390	136	29	42	42	NUM
admet-390	136	30	]	]	PUNCT
admet-390	136	31	.	.	PUNCT
admet-390	137	1	quantification	quantification	NOUN
admet-390	137	2	of	of	ADP
admet-390	137	3	protein	protein	NOUN
admet-390	137	4	concentration	concentration	NOUN
admet-390	137	5	of	of	ADP
admet-390	137	6	transporter	transporter	NOUN
admet-390	137	7	in	in	ADP
admet-390	137	8	the	the	DET
admet-390	137	9	skin	skin	NOUN
admet-390	137	10	,	,	PUNCT
admet-390	137	11	using	use	VERB
admet-390	137	12	surrogate	surrogate	ADJ
admet-390	137	13	signature	signature	NOUN
admet-390	137	14	peptides	peptide	NOUN
admet-390	137	15	and	and	CCONJ
admet-390	137	16	liquid	liquid	ADJ
admet-390	137	17	chromatography	chromatography	NOUN
admet-390	137	18	-	-	PUNCT
admet-390	137	19	mass	mass	NOUN
admet-390	137	20	spectrometry	spectrometry	NOUN
admet-390	137	21	,	,	PUNCT
admet-390	137	22	overcomes	overcome	VERB
admet-390	137	23	these	these	DET
admet-390	137	24	limitations	limitation	NOUN
admet-390	137	25	[	[	X
admet-390	137	26	43	43	NUM
admet-390	137	27	-	-	SYM
admet-390	137	28	45	45	NUM
admet-390	137	29	]	]	PUNCT
admet-390	137	30	.	.	PUNCT
admet-390	138	1	conclusions	conclusion	NOUN
admet-390	138	2	it	it	PRON
admet-390	138	3	is	be	AUX
admet-390	138	4	clear	clear	ADJ
admet-390	138	5	that	that	SCONJ
admet-390	138	6	many	many	ADJ
admet-390	138	7	drug	drug	NOUN
admet-390	138	8	transporters	transporter	NOUN
admet-390	138	9	(	(	PUNCT
admet-390	138	10	both	both	CCONJ
admet-390	138	11	abcs	abc	NOUN
admet-390	138	12	and	and	CCONJ
admet-390	138	13	slcs	slcs	NOUN
admet-390	138	14	)	)	PUNCT
admet-390	138	15	are	be	AUX
admet-390	138	16	present	present	ADJ
admet-390	138	17	in	in	ADP
admet-390	138	18	human	human	ADJ
admet-390	138	19	skin	skin	NOUN
admet-390	138	20	and	and	CCONJ
admet-390	138	21	different	different	ADJ
admet-390	138	22	in	in	ADP
admet-390	138	23	vitro	vitro	X
admet-390	138	24	skin	skin	NOUN
admet-390	138	25	models	model	NOUN
admet-390	138	26	can	can	AUX
admet-390	138	27	be	be	AUX
admet-390	138	28	used	use	VERB
admet-390	138	29	to	to	PART
admet-390	138	30	investigate	investigate	VERB
admet-390	138	31	the	the	DET
admet-390	138	32	role	role	NOUN
admet-390	138	33	of	of	ADP
admet-390	138	34	drug	drug	NOUN
admet-390	138	35	transporters	transporter	NOUN
admet-390	138	36	in	in	ADP
admet-390	138	37	the	the	DET
admet-390	138	38	skin	skin	NOUN
admet-390	138	39	.	.	PUNCT
admet-390	139	1	despite	despite	SCONJ
admet-390	139	2	a	a	DET
admet-390	139	3	significant	significant	ADJ
admet-390	139	4	difference	difference	NOUN
admet-390	139	5	in	in	ADP
admet-390	139	6	expression	expression	NOUN
admet-390	139	7	profile	profile	NOUN
admet-390	139	8	across	across	ADP
admet-390	139	9	species	specie	NOUN
admet-390	139	10	,	,	PUNCT
admet-390	139	11	we	we	PRON
admet-390	139	12	are	be	AUX
admet-390	139	13	at	at	ADP
admet-390	139	14	the	the	DET
admet-390	139	15	dawn	dawn	NOUN
admet-390	139	16	of	of	ADP
admet-390	139	17	an	an	DET
admet-390	139	18	exciting	exciting	ADJ
admet-390	139	19	period	period	NOUN
admet-390	139	20	where	where	SCONJ
admet-390	139	21	the	the	DET
admet-390	139	22	functional	functional	ADJ
admet-390	139	23	aspects	aspect	NOUN
admet-390	139	24	need	need	VERB
admet-390	139	25	to	to	PART
admet-390	139	26	be	be	AUX
admet-390	139	27	investigated	investigate	VERB
admet-390	139	28	.	.	PUNCT
admet-390	140	1	drug	drug	NOUN
admet-390	140	2	transporters	transporter	NOUN
admet-390	140	3	were	be	AUX
admet-390	140	4	shown	show	VERB
admet-390	140	5	to	to	PART
admet-390	140	6	have	have	VERB
admet-390	140	7	an	an	DET
admet-390	140	8	important	important	ADJ
admet-390	140	9	influence	influence	NOUN
admet-390	140	10	on	on	ADP
admet-390	140	11	transdermal	transdermal	ADJ
admet-390	140	12	drug	drug	NOUN
admet-390	140	13	absorption	absorption	NOUN
admet-390	140	14	in	in	ADP
admet-390	140	15	the	the	DET
admet-390	140	16	skin	skin	NOUN
admet-390	140	17	and	and	CCONJ
admet-390	140	18	to	to	PART
admet-390	140	19	function	function	VERB
admet-390	140	20	in	in	ADP
admet-390	140	21	“	"	PUNCT
admet-390	140	22	absorptive	absorptive	ADJ
admet-390	140	23	”	"	PUNCT
admet-390	140	24	transport	transport	NOUN
admet-390	140	25	,	,	PUNCT
admet-390	140	26	carrying	carry	VERB
admet-390	140	27	drugs	drug	NOUN
admet-390	140	28	from	from	ADP
admet-390	140	29	the	the	DET
admet-390	140	30	skin	skin	NOUN
admet-390	140	31	surface	surface	NOUN
admet-390	140	32	to	to	ADP
admet-390	140	33	the	the	DET
admet-390	140	34	dermis	dermis	NOUN
admet-390	140	35	.	.	PUNCT
admet-390	141	1	this	this	DET
admet-390	141	2	observation	observation	NOUN
admet-390	141	3	might	might	AUX
admet-390	141	4	be	be	AUX
admet-390	141	5	used	use	VERB
admet-390	141	6	to	to	PART
admet-390	141	7	modulate	modulate	VERB
admet-390	141	8	drug	drug	NOUN
admet-390	141	9	distribution	distribution	NOUN
admet-390	141	10	inside	inside	ADP
admet-390	141	11	the	the	DET
admet-390	141	12	skin	skin	NOUN
admet-390	141	13	.	.	PUNCT
admet-390	142	1	if	if	SCONJ
admet-390	142	2	drugs	drug	NOUN
admet-390	142	3	can	can	AUX
admet-390	142	4	be	be	AUX
admet-390	142	5	retained	retain	VERB
admet-390	142	6	in	in	ADP
admet-390	142	7	the	the	DET
admet-390	142	8	epidermis	epidermis	NOUN
admet-390	142	9	compartment	compartment	NOUN
admet-390	142	10	by	by	ADP
admet-390	142	11	inhibition	inhibition	NOUN
admet-390	142	12	of	of	ADP
admet-390	142	13	the	the	DET
admet-390	142	14	transporters	transporter	NOUN
admet-390	142	15	,	,	PUNCT
admet-390	142	16	such	such	ADJ
admet-390	142	17	property	property	NOUN
admet-390	142	18	of	of	ADP
admet-390	142	19	the	the	DET
admet-390	142	20	drug	drug	NOUN
admet-390	142	21	would	would	AUX
admet-390	142	22	be	be	AUX
admet-390	142	23	beneficial	beneficial	ADJ
admet-390	142	24	for	for	ADP
admet-390	142	25	treatment	treatment	NOUN
admet-390	142	26	of	of	ADP
admet-390	142	27	dermatological	dermatological	ADJ
admet-390	142	28	diseases	disease	NOUN
admet-390	142	29	.	.	PUNCT
admet-390	143	1	therefore	therefore	ADV
admet-390	143	2	,	,	PUNCT
admet-390	143	3	it	it	PRON
admet-390	143	4	might	might	AUX
admet-390	143	5	be	be	AUX
admet-390	143	6	feasible	feasible	ADJ
admet-390	143	7	to	to	PART
admet-390	143	8	control	control	VERB
admet-390	143	9	transdermal	transdermal	ADJ
admet-390	143	10	delivery	delivery	NOUN
admet-390	143	11	of	of	ADP
admet-390	143	12	drugs	drug	NOUN
admet-390	143	13	to	to	ADP
admet-390	143	14	specific	specific	ADJ
admet-390	143	15	locations	location	NOUN
admet-390	143	16	in	in	ADP
admet-390	143	17	the	the	DET
admet-390	143	18	skin	skin	NOUN
admet-390	143	19	,	,	PUNCT
admet-390	143	20	by	by	ADP
admet-390	143	21	modulating	modulate	VERB
admet-390	143	22	the	the	DET
admet-390	143	23	function	function	NOUN
admet-390	143	24	of	of	ADP
admet-390	143	25	the	the	DET
admet-390	143	26	transporters	transporter	NOUN
admet-390	143	27	in	in	ADP
admet-390	143	28	the	the	DET
admet-390	143	29	skin	skin	NOUN
admet-390	143	30	.	.	PUNCT
admet-390	144	1	thus	thus	ADV
admet-390	144	2	,	,	PUNCT
admet-390	144	3	drug	drug	NOUN
admet-390	144	4	transporters	transporter	NOUN
admet-390	144	5	might	might	AUX
admet-390	144	6	be	be	AUX
admet-390	144	7	a	a	DET
admet-390	144	8	novel	novel	ADJ
admet-390	144	9	target	target	NOUN
admet-390	144	10	for	for	ADP
admet-390	144	11	improvement	improvement	NOUN
admet-390	144	12	of	of	ADP
admet-390	144	13	drug	drug	NOUN
admet-390	144	14	delivery	delivery	NOUN
admet-390	144	15	to	to	ADP
admet-390	144	16	the	the	DET
admet-390	144	17	skin	skin	NOUN
admet-390	144	18	.	.	PUNCT
admet-390	145	1	references	reference	NOUN
admet-390	145	2	[	[	X
admet-390	145	3	1	1	NUM
admet-390	145	4	]	]	X
admet-390	145	5	c.k	c.k	PROPN
admet-390	145	6	.	.	PROPN
admet-390	145	7	svensson	svensson	PROPN
admet-390	145	8	,	,	PUNCT
admet-390	145	9	drug	drug	NOUN
admet-390	145	10	metabolism	metabolism	NOUN
admet-390	145	11	and	and	CCONJ
admet-390	145	12	disposition	disposition	NOUN
admet-390	145	13	,	,	PUNCT
admet-390	145	14	37	37	NUM
admet-390	145	15	(	(	PUNCT
admet-390	145	16	2009	2009	NUM
admet-390	145	17	)	)	PUNCT
admet-390	145	18	247	247	NUM
admet-390	145	19	-	-	SYM
admet-390	145	20	253	253	NUM
admet-390	145	21	.	.	PUNCT
admet-390	146	1	[	[	X
admet-390	146	2	2	2	NUM
admet-390	146	3	]	]	PUNCT
admet-390	146	4	a.	a.	NOUN
admet-390	146	5	mavon	mavon	PROPN
admet-390	146	6	,	,	PUNCT
admet-390	146	7	c.	c.	PROPN
admet-390	146	8	jacques	jacques	PROPN
admet-390	146	9	-	-	PUNCT
admet-390	146	10	jamin	jamin	PROPN
admet-390	146	11	,	,	PUNCT
admet-390	146	12	cosmetics	cosmetic	NOUN
admet-390	146	13	&	&	CCONJ
admet-390	146	14	toiletries	toiletry	NOUN
admet-390	146	15	,	,	PUNCT
admet-390	146	16	128	128	NUM
admet-390	146	17	(	(	PUNCT
admet-390	146	18	2013	2013	NUM
admet-390	146	19	)	)	PUNCT
admet-390	146	20	98	98	NUM
admet-390	146	21	-	-	SYM
admet-390	146	22	103	103	NUM
admet-390	146	23	.	.	PUNCT
admet-390	147	1	[	[	X
admet-390	147	2	3	3	X
admet-390	147	3	]	]	X
admet-390	147	4	n.	n.	NOUN
admet-390	147	5	manevski	manevski	PROPN
admet-390	147	6	,	,	PUNCT
admet-390	147	7	p	p	PROPN
admet-390	147	8	swart	swart	PROPN
admet-390	147	9	,	,	PUNCT
admet-390	147	10	k.k	k.k	PROPN
admet-390	147	11	.	.	PROPN
admet-390	147	12	balavenkatratam	balavenkatratam	PROPN
admet-390	147	13	,	,	PUNCT
admet-390	147	14	b.	b.	PROPN
admet-390	147	15	bertschi	bertschi	PROPN
admet-390	147	16	,	,	PUNCT
admet-390	147	17	g.	g.	PROPN
admet-390	147	18	camenish	camenish	PROPN
admet-390	147	19	,	,	PUNCT
admet-390	147	20	o.	o.	PROPN
admet-390	147	21	kretz	kretz	PROPN
admet-390	147	22	,	,	PUNCT
admet-390	147	23	h.	h.	PROPN
admet-390	147	24	schiller	schiller	PROPN
admet-390	147	25	,	,	PUNCT
admet-390	147	26	m.	m.	NOUN
admet-390	147	27	walles	walles	PROPN
admet-390	147	28	,	,	PUNCT
admet-390	147	29	b.	b.	PROPN
admet-390	147	30	ling	ling	PROPN
admet-390	147	31	,	,	PUNCT
admet-390	147	32	r.	r.	PROPN
admet-390	147	33	wettstein	wettstein	PROPN
admet-390	147	34	,	,	PUNCT
admet-390	147	35	d.j	d.j	PROPN
admet-390	147	36	.	.	PROPN
admet-390	147	37	schaefer	schaefer	PROPN
admet-390	147	38	,	,	PUNCT
admet-390	147	39	p.	p.	PROPN
admet-390	147	40	itin	itin	PROPN
admet-390	147	41	,	,	PUNCT
admet-390	147	42	j.	j.	PROPN
admet-390	147	43	ashton	ashton	PROPN
admet-390	147	44	-	-	PUNCT
admet-390	147	45	chess	chess	PROPN
admet-390	147	46	,	,	PUNCT
admet-390	147	47	f.	f.	PROPN
admet-390	147	48	pognan	pognan	PROPN
admet-390	147	49	,	,	PUNCT
admet-390	147	50	a.	a.	NOUN
admet-390	147	51	wolf	wolf	PROPN
admet-390	147	52	,	,	PUNCT
admet-390	147	53	k.	k.	PROPN
admet-390	147	54	litherland	litherland	PROPN
admet-390	147	55	,	,	PUNCT
admet-390	147	56	drug	drug	NOUN
admet-390	147	57	metabolism	metabolism	NOUN
admet-390	147	58	and	and	CCONJ
admet-390	147	59	disposition	disposition	NOUN
admet-390	147	60	,	,	PUNCT
admet-390	147	61	43	43	NUM
admet-390	147	62	(	(	PUNCT
admet-390	147	63	2015	2015	NUM
admet-390	147	64	)	)	PUNCT
admet-390	147	65	126	126	NUM
admet-390	147	66	-	-	SYM
admet-390	147	67	139	139	NUM
admet-390	147	68	.	.	PUNCT
admet-390	148	1	[	[	X
admet-390	148	2	4	4	X
admet-390	148	3	]	]	X
admet-390	148	4	f.	f.	PROPN
admet-390	148	5	oesch	oesch	PROPN
admet-390	148	6	,	,	PUNCT
admet-390	148	7	e.	e.	PROPN
admet-390	148	8	fabian	fabian	PROPN
admet-390	148	9	,	,	PUNCT
admet-390	148	10	k.	k.	PROPN
admet-390	148	11	guth	guth	PROPN
admet-390	148	12	,	,	PUNCT
admet-390	148	13	r.	r.	PROPN
admet-390	148	14	landsiedel	landsiedel	PROPN
admet-390	148	15	,	,	PUNCT
admet-390	148	16	archives	archive	NOUN
admet-390	148	17	of	of	ADP
admet-390	148	18	toxicology	toxicology	NOUN
admet-390	148	19	,	,	PUNCT
admet-390	148	20	88	88	NUM
admet-390	148	21	(	(	PUNCT
admet-390	148	22	2014	2014	NUM
admet-390	148	23	)	)	PUNCT
admet-390	148	24	2135	2135	NUM
admet-390	148	25	-	-	SYM
admet-390	148	26	2190	2190	NUM
admet-390	148	27	.	.	PUNCT
admet-390	149	1	[	[	X
admet-390	149	2	5	5	NUM
admet-390	149	3	]	]	PUNCT
admet-390	149	4	https://en.wikipedia.org/wiki/topical_medication	https://en.wikipedia.org/wiki/topical_medication	NOUN
admet-390	149	5	,	,	PUNCT
admet-390	149	6	(	(	PUNCT
admet-390	149	7	april	april	PROPN
admet-390	149	8	2017	2017	NUM
admet-390	149	9	)	)	PUNCT
admet-390	149	10	.	.	PUNCT
admet-390	150	1	[	[	X
admet-390	150	2	6	6	NUM
admet-390	150	3	]	]	PUNCT
admet-390	150	4	g.	g.	PROPN
admet-390	150	5	martin	martin	PROPN
admet-390	150	6	-	-	PUNCT
admet-390	150	7	bouyer	bouyer	PROPN
admet-390	150	8	,	,	PUNCT
admet-390	150	9	m.	m.	PROPN
admet-390	150	10	toga	toga	PROPN
admet-390	150	11	,	,	PUNCT
admet-390	150	12	r.	r.	PROPN
admet-390	150	13	lebreton	lebreton	PROPN
admet-390	150	14	,	,	PUNCT
admet-390	150	15	p.d	p.d	PROPN
admet-390	150	16	.	.	PROPN
admet-390	150	17	stolley	stolley	PROPN
admet-390	150	18	,	,	PUNCT
admet-390	150	19	j.	j.	PROPN
admet-390	150	20	lockhart	lockhart	PROPN
admet-390	150	21	,	,	PUNCT
admet-390	150	22	the	the	DET
admet-390	150	23	lancet	lancet	NOUN
admet-390	150	24	,	,	PUNCT
admet-390	150	25	319	319	NUM
admet-390	150	26	(	(	PUNCT
admet-390	150	27	1982	1982	NUM
admet-390	150	28	)	)	PUNCT
admet-390	150	29	91	91	NUM
admet-390	150	30	-	-	SYM
admet-390	150	31	95	95	NUM
admet-390	150	32	.	.	PUNCT
admet-390	151	1	[	[	X
admet-390	151	2	7	7	X
admet-390	151	3	]	]	X
admet-390	151	4	non	non	ADJ
admet-390	151	5	clinical	clinical	ADJ
admet-390	151	6	safety	safety	NOUN
admet-390	151	7	evaluation	evaluation	NOUN
admet-390	151	8	of	of	ADP
admet-390	151	9	reformulated	reformulate	VERB
admet-390	151	10	drug	drug	NOUN
admet-390	151	11	products	product	NOUN
admet-390	151	12	and	and	CCONJ
admet-390	151	13	products	product	NOUN
admet-390	151	14	for	for	ADP
admet-390	151	15	administration	administration	NOUN
admet-390	151	16	by	by	ADP
admet-390	151	17	an	an	DET
admet-390	151	18	alternate	alternate	ADJ
admet-390	151	19	route	route	NOUN
admet-390	151	20	,	,	PUNCT
admet-390	151	21	fda	fda	PROPN
admet-390	151	22	guidance	guidance	NOUN
admet-390	151	23	for	for	ADP
admet-390	151	24	industry	industry	NOUN
admet-390	151	25	and	and	CCONJ
admet-390	151	26	review	review	NOUN
admet-390	151	27	staff	staff	NOUN
admet-390	151	28	,	,	PUNCT
admet-390	151	29	oct	oct	PROPN
admet-390	151	30	2015	2015	NUM
admet-390	151	31	.	.	PUNCT
admet-390	152	1	[	[	X
admet-390	152	2	8	8	NUM
admet-390	152	3	]	]	X
admet-390	152	4	j.m	j.m	PROPN
admet-390	152	5	.	.	PROPN
admet-390	152	6	baron	baron	PROPN
admet-390	152	7	,	,	PUNCT
admet-390	152	8	d.	d.	PROPN
admet-390	152	9	holler	holler	PROPN
admet-390	152	10	,	,	PUNCT
admet-390	152	11	r.	r.	PROPN
admet-390	152	12	schiffer	schiffer	PROPN
admet-390	152	13	,	,	PUNCT
admet-390	152	14	s.	s.	PROPN
admet-390	152	15	frankenberg	frankenberg	PROPN
admet-390	152	16	,	,	PUNCT
admet-390	152	17	m.	m.	NOUN
admet-390	152	18	neis	neis	PROPN
admet-390	152	19	,	,	PUNCT
admet-390	152	20	h.f	h.f	PROPN
admet-390	152	21	.	.	PROPN
admet-390	152	22	merck	merck	PROPN
admet-390	152	23	,	,	PUNCT
admet-390	152	24	f.k	f.k	PROPN
admet-390	152	25	.	.	PROPN
admet-390	152	26	jugert	jugert	PROPN
admet-390	152	27	,	,	PUNCT
admet-390	152	28	journal	journal	NOUN
admet-390	152	29	of	of	ADP
admet-390	152	30	investigative	investigative	ADJ
admet-390	152	31	dermatology	dermatology	NOUN
admet-390	152	32	,	,	PUNCT
admet-390	152	33	116	116	NUM
admet-390	152	34	(	(	PUNCT
admet-390	152	35	2001	2001	NUM
admet-390	152	36	)	)	PUNCT
admet-390	152	37	541	541	NUM
admet-390	152	38	-	-	SYM
admet-390	152	39	548	548	NUM
admet-390	152	40	.	.	PUNCT
admet-390	153	1	[	[	X
admet-390	153	2	9	9	NUM
admet-390	153	3	]	]	PUNCT
admet-390	153	4	r.	r.	PROPN
admet-390	153	5	schiffer	schiffer	PROPN
admet-390	153	6	,	,	PUNCT
admet-390	153	7	m.	m.	NOUN
admet-390	153	8	neis	neis	PROPN
admet-390	153	9	,	,	PUNCT
admet-390	153	10	d.	d.	PROPN
admet-390	153	11	höller	höller	PROPN
admet-390	153	12	,	,	PUNCT
admet-390	153	13	f.	f.	PROPN
admet-390	153	14	rodriguez	rodriguez	PROPN
admet-390	153	15	,	,	PUNCT
admet-390	153	16	a.	a.	NOUN
admet-390	153	17	geier	geier	NOUN
admet-390	153	18	,	,	PUNCT
admet-390	153	19	c.	c.	PROPN
admet-390	153	20	gartung	gartung	PROPN
admet-390	153	21	,	,	PUNCT
admet-390	153	22	f.	f.	PROPN
admet-390	153	23	lammert	lammert	PROPN
admet-390	153	24	,	,	PUNCT
admet-390	153	25	a.	a.	PROPN
admet-390	153	26	dreuw	dreuw	PROPN
admet-390	153	27	,	,	PUNCT
admet-390	153	28	g.	g.	PROPN
admet-390	153	29	zwadloklarwasser	zwadloklarwasser	PROPN
admet-390	153	30	,	,	PUNCT
admet-390	153	31	h.	h.	PROPN
admet-390	153	32	merck	merck	PROPN
admet-390	153	33	,	,	PUNCT
admet-390	153	34	f.	f.	PROPN
admet-390	153	35	jugert	jugert	PROPN
admet-390	153	36	,	,	PUNCT
admet-390	153	37	j.m	j.m	PROPN
admet-390	153	38	.	.	PROPN
admet-390	153	39	baron	baron	PROPN
admet-390	153	40	,	,	PUNCT
admet-390	153	41	journal	journal	NOUN
admet-390	153	42	of	of	ADP
admet-390	153	43	investigative	investigative	ADJ
admet-390	153	44	dermatology	dermatology	NOUN
admet-390	153	45	,	,	PUNCT
admet-390	153	46	120	120	NUM
admet-390	153	47	(	(	PUNCT
admet-390	153	48	2003	2003	NUM
admet-390	153	49	)	)	PUNCT
admet-390	153	50	285291	285291	NUM
admet-390	153	51	.	.	PUNCT
admet-390	154	1	[	[	X
admet-390	154	2	10	10	NUM
admet-390	154	3	]	]	X
admet-390	154	4	h.	h.	PROPN
admet-390	154	5	schaeffer	schaeffer	PROPN
admet-390	154	6	,	,	PUNCT
admet-390	154	7	t.	t.	NOUN
admet-390	154	8	redelmeier	redelmeier	NOUN
admet-390	154	9	,	,	PUNCT
admet-390	154	10	skin	skin	NOUN
admet-390	154	11	barrier	barrier	NOUN
admet-390	154	12	:	:	PUNCT
admet-390	154	13	principles	principle	NOUN
admet-390	154	14	of	of	ADP
admet-390	154	15	percutaneous	percutaneous	ADJ
admet-390	154	16	absorption	absorption	NOUN
admet-390	154	17	,	,	PUNCT
admet-390	154	18	s.	s.	PROPN
admet-390	154	19	karger	karger	PROPN
admet-390	154	20	,	,	PUNCT
admet-390	154	21	basel	basel	PROPN
admet-390	154	22	,	,	PUNCT
admet-390	154	23	ch	ch	NOUN
admet-390	154	24	,	,	PUNCT
admet-390	154	25	1996	1996	NUM
admet-390	154	26	.	.	PUNCT
admet-390	155	1	[	[	X
admet-390	155	2	11	11	NUM
admet-390	155	3	]	]	X
admet-390	155	4	h.	h.	PROPN
admet-390	155	5	swanson	swanson	PROPN
admet-390	155	6	,	,	PUNCT
admet-390	155	7	chemico	chemico	NOUN
admet-390	155	8	-	-	ADJ
admet-390	155	9	biological	biological	ADJ
admet-390	155	10	interactions	interaction	NOUN
admet-390	155	11	,	,	PUNCT
admet-390	155	12	149	149	NUM
admet-390	155	13	(	(	PUNCT
admet-390	155	14	2004	2004	NUM
admet-390	155	15	)	)	PUNCT
admet-390	155	16	69	69	NUM
admet-390	155	17	-	-	SYM
admet-390	155	18	79	79	NUM
admet-390	155	19	.	.	PUNCT
admet-390	156	1	[	[	X
admet-390	156	2	12	12	NUM
admet-390	156	3	]	]	PUNCT
admet-390	156	4	a.	a.	NOUN
admet-390	156	5	williams	williams	PROPN
admet-390	156	6	,	,	PUNCT
admet-390	156	7	transdermal	transdermal	ADJ
admet-390	156	8	and	and	CCONJ
admet-390	156	9	topical	topical	ADJ
admet-390	156	10	drug	drug	NOUN
admet-390	156	11	delivery	delivery	NOUN
admet-390	156	12	,	,	PUNCT
admet-390	156	13	pharmaceutical	pharmaceutical	NOUN
admet-390	156	14	press	press	NOUN
admet-390	156	15	,	,	PUNCT
admet-390	156	16	london	london	PROPN
admet-390	156	17	,	,	PUNCT
admet-390	156	18	2003	2003	NUM
admet-390	156	19	.	.	PUNCT
admet-390	157	1	[	[	X
admet-390	157	2	13	13	NUM
admet-390	157	3	]	]	PUNCT
admet-390	157	4	m.	m.	NOUN
admet-390	157	5	pham	pham	PROPN
admet-390	157	6	,	,	PUNCT
admet-390	157	7	j.	j.	PROPN
admet-390	157	8	magdalou	magdalou	PROPN
admet-390	157	9	,	,	PUNCT
admet-390	157	10	m.	m.	PROPN
admet-390	157	11	totis	totis	PROPN
admet-390	157	12	,	,	PUNCT
admet-390	157	13	s.	s.	PROPN
admet-390	157	14	fournel	fournel	PROPN
admet-390	157	15	-	-	PUNCT
admet-390	157	16	gigleux	gigleux	PROPN
admet-390	157	17	,	,	PUNCT
admet-390	157	18	g.	g.	PROPN
admet-390	157	19	siest	siest	PROPN
admet-390	157	20	,	,	PUNCT
admet-390	157	21	b.	b.	PROPN
admet-390	157	22	hammock	hammock	NOUN
admet-390	157	23	,	,	PUNCT
admet-390	157	24	biochemical	biochemical	ADJ
admet-390	157	25	pharmacology	pharmacology	NOUN
admet-390	157	26	,	,	PUNCT
admet-390	157	27	38	38	NUM
admet-390	157	28	(	(	PUNCT
admet-390	157	29	1989	1989	NUM
admet-390	157	30	)	)	PUNCT
admet-390	157	31	2187	2187	NUM
admet-390	157	32	-	-	SYM
admet-390	157	33	2194	2194	NUM
admet-390	157	34	.	.	PUNCT
admet-390	158	1	[	[	X
admet-390	158	2	14	14	NUM
admet-390	158	3	]	]	X
admet-390	158	4	k.	k.	PROPN
admet-390	158	5	madison	madison	PROPN
admet-390	158	6	,	,	PUNCT
admet-390	158	7	journal	journal	NOUN
admet-390	158	8	of	of	ADP
admet-390	158	9	investigative	investigative	ADJ
admet-390	158	10	dermatology	dermatology	NOUN
admet-390	158	11	,	,	PUNCT
admet-390	158	12	121	121	NUM
admet-390	158	13	(	(	PUNCT
admet-390	158	14	2003	2003	NUM
admet-390	158	15	)	)	PUNCT
admet-390	158	16	231	231	NUM
admet-390	158	17	-	-	SYM
admet-390	158	18	241	241	NUM
admet-390	158	19	.	.	PUNCT
admet-390	159	1	[	[	X
admet-390	159	2	15	15	NUM
admet-390	159	3	]	]	X
admet-390	159	4	m.	m.	NOUN
admet-390	159	5	prausnitz	prausnitz	NOUN
admet-390	159	6	,	,	PUNCT
admet-390	159	7	s.	s.	PROPN
admet-390	159	8	mitragotri	mitragotri	PROPN
admet-390	159	9	,	,	PUNCT
admet-390	159	10	r.	r.	PROPN
admet-390	159	11	langer	langer	PROPN
admet-390	159	12	,	,	PUNCT
admet-390	159	13	nature	nature	NOUN
admet-390	159	14	reviews	review	VERB
admet-390	159	15	drug	drug	NOUN
admet-390	159	16	discovery	discovery	NOUN
admet-390	159	17	,	,	PUNCT
admet-390	159	18	3	3	NUM
admet-390	159	19	(	(	PUNCT
admet-390	159	20	2004	2004	NUM
admet-390	159	21	)	)	PUNCT
admet-390	159	22	115	115	NUM
admet-390	159	23	-	-	SYM
admet-390	159	24	124	124	NUM
admet-390	159	25	.	.	PUNCT
admet-390	160	1	[	[	X
admet-390	160	2	16	16	NUM
admet-390	160	3	]	]	X
admet-390	160	4	c.	c.	PROPN
admet-390	160	5	jacques	jacques	PROPN
admet-390	160	6	,	,	PUNCT
admet-390	160	7	e.	e.	PROPN
admet-390	160	8	perdu	perdu	PROPN
admet-390	160	9	,	,	PUNCT
admet-390	160	10	e.l	e.l	PROPN
admet-390	160	11	.	.	PROPN
admet-390	160	12	jamin	jamin	PROPN
admet-390	160	13	,	,	PUNCT
admet-390	160	14	j.p	j.p	PROPN
admet-390	160	15	.	.	PROPN
admet-390	160	16	cravedi	cravedi	PROPN
admet-390	160	17	,	,	PUNCT
admet-390	160	18	a.	a.	PROPN
admet-390	160	19	mavon	mavon	PROPN
admet-390	160	20	,	,	PUNCT
admet-390	160	21	h.	h.	PROPN
admet-390	160	22	duplan	duplan	PROPN
admet-390	160	23	,	,	PUNCT
admet-390	160	24	d.	d.	PROPN
admet-390	160	25	zalko	zalko	PROPN
admet-390	160	26	,	,	PUNCT
admet-390	160	27	skin	skin	NOUN
admet-390	160	28	pharmacol	pharmacol	PROPN
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admet-390	160	30	,	,	PUNCT
admet-390	160	31	27	27	NUM
admet-390	160	32	(	(	PUNCT
admet-390	160	33	2014	2014	NUM
admet-390	160	34	)	)	PUNCT
admet-390	160	35	188	188	NUM
admet-390	160	36	-	-	SYM
admet-390	160	37	200	200	NUM
admet-390	160	38	.	.	PUNCT
admet-390	161	1	admet	admet	PROPN
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admet-390	161	3	dmpk	dmpk	PROPN
admet-390	161	4	5(2	5(2	NUM
admet-390	161	5	)	)	PUNCT
admet-390	161	6	(	(	PUNCT
admet-390	161	7	2017	2017	NUM
admet-390	161	8	)	)	PUNCT
admet-390	161	9	75	75	NUM
admet-390	161	10	-	-	SYM
admet-390	161	11	84	84	NUM
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admet-390	161	14	drug	drug	NOUN
admet-390	161	15	transporters	transporter	NOUN
admet-390	161	16	in	in	ADP
admet-390	161	17	the	the	DET
admet-390	161	18	human	human	ADJ
admet-390	161	19	skin	skin	NOUN
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admet-390	161	21	:	:	PUNCT
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admet-390	161	23	/	/	SYM
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admet-390	161	25	83	83	NUM
admet-390	161	26	[	[	SYM
admet-390	161	27	17	17	NUM
admet-390	161	28	]	]	X
admet-390	161	29	q.	q.	PROPN
admet-390	161	30	li	li	PROPN
admet-390	161	31	,	,	PUNCT
admet-390	161	32	h.	h.	PROPN
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admet-390	161	34	,	,	PUNCT
admet-390	161	35	y	y	PROPN
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admet-390	161	37	,	,	PUNCT
admet-390	161	38	y.	y.	PROPN
admet-390	161	39	sai	sai	PROPN
admet-390	161	40	,	,	PUNCT
admet-390	161	41	y.	y.	PROPN
admet-390	161	42	kubo	kubo	PROPN
admet-390	161	43	,	,	PUNCT
admet-390	161	44	a.	a.	PROPN
admet-390	161	45	tsuji	tsuji	PROPN
admet-390	161	46	,	,	PUNCT
admet-390	161	47	journal	journal	NOUN
admet-390	161	48	of	of	ADP
admet-390	161	49	controlled	control	VERB
admet-390	161	50	release	release	NOUN
admet-390	161	51	,	,	PUNCT
admet-390	161	52	110	110	NUM
admet-390	161	53	(	(	PUNCT
admet-390	161	54	2006	2006	NUM
admet-390	161	55	)	)	PUNCT
admet-390	161	56	542	542	NUM
admet-390	161	57	-	-	SYM
admet-390	161	58	546	546	NUM
admet-390	161	59	.	.	PUNCT
admet-390	162	1	[	[	X
admet-390	162	2	18	18	NUM
admet-390	162	3	]	]	PUNCT
admet-390	162	4	k.	k.	PROPN
admet-390	162	5	ito	ito	PROPN
admet-390	162	6	,	,	PUNCT
admet-390	162	7	h.t	h.t	PROPN
admet-390	162	8	.	.	PROPN
admet-390	162	9	nguyen	nguyen	PROPN
admet-390	162	10	,	,	PUNCT
admet-390	162	11	y.	y.	PROPN
admet-390	162	12	kato	kato	PROPN
admet-390	162	13	,	,	PUNCT
admet-390	162	14	t.	t.	PROPN
admet-390	162	15	wakayama	wakayama	PROPN
admet-390	162	16	,	,	PUNCT
admet-390	162	17	y.	y.	PROPN
admet-390	162	18	kubo	kubo	PROPN
admet-390	162	19	,	,	PUNCT
admet-390	162	20	s.	s.	PROPN
admet-390	162	21	iseki	iseki	PROPN
admet-390	162	22	,	,	PUNCT
admet-390	162	23	a.	a.	PROPN
admet-390	162	24	tsuji	tsuji	PROPN
admet-390	162	25	,	,	PUNCT
admet-390	162	26	journal	journal	NOUN
admet-390	162	27	of	of	ADP
admet-390	162	28	controlled	control	VERB
admet-390	162	29	release	release	NOUN
admet-390	162	30	,	,	PUNCT
admet-390	162	31	131	131	NUM
admet-390	162	32	(	(	PUNCT
admet-390	162	33	2008	2008	NUM
admet-390	162	34	)	)	PUNCT
admet-390	162	35	198	198	NUM
admet-390	162	36	-	-	SYM
admet-390	162	37	204	204	NUM
admet-390	162	38	.	.	PUNCT
admet-390	163	1	[	[	X
admet-390	163	2	19	19	NUM
admet-390	163	3	]	]	X
admet-390	163	4	i.s	i.s	PROPN
admet-390	163	5	.	.	PROPN
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admet-390	163	7	,	,	PUNCT
admet-390	163	8	c.	c.	PROPN
admet-390	163	9	el	el	PROPN
admet-390	163	10	-	-	PROPN
admet-390	163	11	chami	chami	PROPN
admet-390	163	12	,	,	PUNCT
admet-390	163	13	a.	a.	NOUN
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admet-390	163	15	,	,	PUNCT
admet-390	163	16	c.a	c.a	PROPN
admet-390	163	17	.	.	PROPN
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admet-390	163	19	,	,	PUNCT
admet-390	163	20	r.	r.	PROPN
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admet-390	163	22	,	,	PUNCT
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admet-390	163	25	of	of	ADP
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admet-390	163	27	,	,	PUNCT
admet-390	163	28	172	172	NUM
admet-390	163	29	(	(	PUNCT
admet-390	163	30	2015	2015	NUM
admet-390	163	31	)	)	PUNCT
admet-390	163	32	1562	1562	NUM
admet-390	163	33	-	-	SYM
admet-390	163	34	1572	1572	NUM
admet-390	163	35	.	.	PUNCT
admet-390	164	1	[	[	X
admet-390	164	2	20	20	NUM
admet-390	164	3	]	]	X
admet-390	164	4	h.	h.	PROPN
admet-390	164	5	osman	osman	PROPN
admet-390	164	6	-	-	PUNCT
admet-390	164	7	ponchet	ponchet	PROPN
admet-390	164	8	,	,	PUNCT
admet-390	164	9	a.	a.	NOUN
admet-390	164	10	boulai	boulai	PROPN
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admet-390	164	12	m.	m.	NOUN
admet-390	164	13	kouidhi	kouidhi	PROPN
admet-390	164	14	,	,	PUNCT
admet-390	164	15	k.	k.	PROPN
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admet-390	164	17	,	,	PUNCT
admet-390	164	18	m.	m.	NOUN
admet-390	164	19	alriquet	alriquet	PROPN
admet-390	164	20	,	,	PUNCT
admet-390	164	21	a.	a.	NOUN
admet-390	164	22	gaborit	gaborit	PROPN
admet-390	164	23	,	,	PUNCT
admet-390	164	24	b.	b.	PROPN
admet-390	164	25	bertino	bertino	PROPN
admet-390	164	26	,	,	PUNCT
admet-390	164	27	p.	p.	PROPN
admet-390	164	28	comby	comby	PROPN
admet-390	164	29	,	,	PUNCT
admet-390	164	30	b.	b.	PROPN
admet-390	164	31	ruty	ruty	PROPN
admet-390	164	32	,	,	PUNCT
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admet-390	164	35	and	and	CCONJ
admet-390	164	36	drug	drug	NOUN
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admet-390	164	38	,	,	PUNCT
admet-390	164	39	29	29	NUM
admet-390	164	40	(	(	PUNCT
admet-390	164	41	2014	2014	NUM
admet-390	164	42	)	)	PUNCT
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admet-390	164	44	-	-	SYM
admet-390	164	45	100	100	NUM
admet-390	164	46	.	.	PUNCT
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admet-390	165	2	21	21	NUM
admet-390	165	3	]	]	X
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admet-390	165	9	,	,	PUNCT
admet-390	165	10	r.	r.	PROPN
admet-390	165	11	fujiwara	fujiwara	PROPN
admet-390	165	12	,	,	PUNCT
admet-390	165	13	pharmacology	pharmacology	NOUN
admet-390	165	14	research	research	NOUN
admet-390	165	15	&	&	CCONJ
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admet-390	165	17	,	,	PUNCT
admet-390	165	18	1	1	NUM
admet-390	165	19	(	(	PUNCT
admet-390	165	20	2013	2013	NUM
admet-390	165	21	)	)	PUNCT
admet-390	165	22	1	1	NUM
admet-390	165	23	-	-	SYM
admet-390	165	24	8	8	NUM
admet-390	165	25	.	.	PUNCT
admet-390	166	1	[	[	X
admet-390	166	2	22	22	NUM
admet-390	166	3	]	]	X
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admet-390	166	6	,	,	PUNCT
admet-390	166	7	n.	n.	PROPN
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admet-390	166	9	,	,	PUNCT
admet-390	166	10	s.	s.	PROPN
admet-390	166	11	uwafuji	uwafuji	PROPN
admet-390	166	12	,	,	PUNCT
admet-390	166	13	k.	k.	PROPN
admet-390	166	14	yoshida	yoshida	PROPN
admet-390	166	15	,	,	PUNCT
admet-390	166	16	t.	t.	NOUN
admet-390	166	17	sugiura	sugiura	NOUN
admet-390	166	18	,	,	PUNCT
admet-390	166	19	a.	a.	PROPN
admet-390	166	20	tsuji	tsuji	PROPN
admet-390	166	21	,	,	PUNCT
admet-390	166	22	y.	y.	PROPN
admet-390	166	23	kato	kato	PROPN
admet-390	166	24	,	,	PUNCT
admet-390	166	25	journal	journal	NOUN
admet-390	166	26	of	of	ADP
admet-390	166	27	controlled	control	VERB
admet-390	166	28	release	release	NOUN
admet-390	166	29	,	,	PUNCT
admet-390	166	30	165	165	NUM
admet-390	166	31	(	(	PUNCT
admet-390	166	32	2013	2013	NUM
admet-390	166	33	)	)	PUNCT
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admet-390	166	35	-	-	SYM
admet-390	166	36	61	61	NUM
admet-390	166	37	.	.	PUNCT
admet-390	167	1	[	[	X
admet-390	167	2	23	23	NUM
admet-390	167	3	]	]	PUNCT
admet-390	167	4	k.	k.	PROPN
admet-390	168	1	bleasby	bleasby	PROPN
admet-390	168	2	,	,	PUNCT
admet-390	168	3	j.c	j.c	PROPN
admet-390	168	4	.	.	PROPN
admet-390	168	5	castle	castle	PROPN
admet-390	168	6	,	,	PUNCT
admet-390	168	7	c.j	c.j	PROPN
admet-390	168	8	.	.	PROPN
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admet-390	168	10	,	,	PUNCT
admet-390	168	11	c.	c.	PROPN
admet-390	168	12	cheng	cheng	PROPN
admet-390	168	13	,	,	PUNCT
admet-390	168	14	w.j	w.j	PROPN
admet-390	168	15	.	.	PROPN
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admet-390	168	17	,	,	PUNCT
admet-390	168	18	j.f	j.f	PROPN
admet-390	168	19	.	.	PROPN
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admet-390	168	21	,	,	PUNCT
admet-390	168	22	a.v	a.v	PROPN
admet-390	168	23	.	.	PROPN
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admet-390	168	25	,	,	PUNCT
admet-390	168	26	m.j	m.j	PROPN
admet-390	168	27	.	.	PROPN
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admet-390	168	29	,	,	PUNCT
admet-390	168	30	r.evers	r.ever	NOUN
admet-390	168	31	,	,	PUNCT
admet-390	168	32	j.m	j.m	PROPN
admet-390	168	33	.	.	PROPN
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admet-390	168	35	,	,	PUNCT
admet-390	168	36	r.g	r.g	PROPN
admet-390	168	37	.	.	PROPN
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admet-390	168	39	,	,	PUNCT
admet-390	168	40	j.g	j.g	PROPN
admet-390	168	41	.	.	PROPN
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admet-390	168	43	,	,	PUNCT
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admet-390	168	45	,	,	PUNCT
admet-390	168	46	36	36	NUM
admet-390	168	47	(	(	PUNCT
admet-390	168	48	2006	2006	NUM
admet-390	168	49	)	)	PUNCT
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admet-390	168	51	-	-	SYM
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admet-390	168	53	.	.	PUNCT
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admet-390	169	2	24	24	NUM
admet-390	169	3	]	]	PUNCT
admet-390	169	4	m.	m.	NOUN
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admet-390	169	6	,	,	PUNCT
admet-390	169	7	k.	k.	PROPN
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admet-390	169	9	,	,	PUNCT
admet-390	169	10	a.	a.	NOUN
admet-390	169	11	gaborit	gaborit	PROPN
admet-390	169	12	,	,	PUNCT
admet-390	169	13	p.	p.	PROPN
admet-390	169	14	comby	comby	PROPN
admet-390	169	15	,	,	PUNCT
admet-390	169	16	b.	b.	PROPN
admet-390	169	17	ruty	ruty	PROPN
admet-390	169	18	,	,	PUNCT
admet-390	169	19	h.	h.	PROPN
admet-390	169	20	osman	osman	PROPN
admet-390	169	21	-	-	PUNCT
admet-390	169	22	ponchet	ponchet	NOUN
admet-390	169	23	,	,	PUNCT
admet-390	169	24	admet	admet	PROPN
admet-390	169	25	&	&	CCONJ
admet-390	169	26	dmpk	dmpk	PROPN
admet-390	169	27	,	,	PUNCT
admet-390	169	28	3	3	NUM
admet-390	169	29	(	(	PUNCT
admet-390	169	30	2015	2015	NUM
admet-390	169	31	)	)	PUNCT
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admet-390	169	33	-	-	SYM
admet-390	169	34	44	44	NUM
admet-390	169	35	.	.	PUNCT
admet-390	170	1	[	[	X
admet-390	170	2	25	25	NUM
admet-390	170	3	]	]	X
admet-390	170	4	r.	r.	PROPN
admet-390	170	5	fujiwara	fujiwara	PROPN
admet-390	170	6	,	,	PUNCT
admet-390	170	7	s.	s.	PROPN
admet-390	170	8	takenada	takenada	PROPN
admet-390	170	9	,	,	PUNCT
admet-390	170	10	m.	m.	NOUN
admet-390	170	11	hashimoto	hashimoto	NOUN
admet-390	170	12	,	,	PUNCT
admet-390	170	13	t.	t.	PROPN
admet-390	170	14	narawa	narawa	PROPN
admet-390	170	15	,	,	PUNCT
admet-390	170	16	t	t	PROPN
admet-390	170	17	,	,	PUNCT
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admet-390	170	19	,	,	PUNCT
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admet-390	170	22	,	,	PUNCT
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admet-390	170	24	(	(	PUNCT
admet-390	170	25	2014	2014	NUM
admet-390	170	26	)	)	PUNCT
admet-390	170	27	1	1	NUM
admet-390	170	28	-	-	SYM
admet-390	170	29	8	8	NUM
admet-390	170	30	.	.	PUNCT
admet-390	171	1	[	[	X
admet-390	171	2	26	26	NUM
admet-390	171	3	]	]	X
admet-390	171	4	h.	h.	PROPN
admet-390	171	5	osman	osman	PROPN
admet-390	171	6	-	-	PUNCT
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admet-390	171	8	,	,	PUNCT
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admet-390	171	10	euro	euro	NOUN
admet-390	171	11	-	-	PUNCT
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admet-390	171	19	,	,	PUNCT
admet-390	171	20	october	october	PROPN
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admet-390	171	22	,	,	PUNCT
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admet-390	171	25	,	,	PUNCT
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admet-390	171	27	.	.	PUNCT
admet-390	172	1	[	[	X
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admet-390	172	3	]	]	X
admet-390	172	4	c.	c.	PROPN
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admet-390	172	6	,	,	PUNCT
admet-390	172	7	j.	j.	PROPN
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admet-390	172	9	,	,	PUNCT
admet-390	172	10	y.	y.	PROPN
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admet-390	172	12	,	,	PUNCT
admet-390	172	13	a.	a.	PROPN
admet-390	172	14	kim	kim	PROPN
admet-390	172	15	,	,	PUNCT
admet-390	172	16	h.f	h.f	PROPN
admet-390	172	17	.	.	PROPN
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admet-390	172	19	,	,	PUNCT
admet-390	172	20	d.r	d.r	PROPN
admet-390	172	21	.	.	PROPN
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admet-390	172	27	,	,	PUNCT
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admet-390	172	30	,	,	PUNCT
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admet-390	172	32	(	(	PUNCT
admet-390	172	33	2011	2011	NUM
admet-390	172	34	)	)	PUNCT
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admet-390	172	36	-	-	SYM
admet-390	172	37	452	452	NUM
admet-390	172	38	.	.	PUNCT
admet-390	173	1	[	[	X
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admet-390	173	3	]	]	X
admet-390	173	4	m.a	m.a	PROPN
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admet-390	173	22	(	(	PUNCT
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admet-390	173	24	)	)	PUNCT
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admet-390	173	26	-	-	SYM
admet-390	173	27	23	23	NUM
admet-390	173	28	.	.	PUNCT
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admet-390	174	13	m.	m.	NOUN
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admet-390	174	15	,	,	PUNCT
admet-390	174	16	y.	y.	PROPN
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admet-390	174	18	,	,	PUNCT
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admet-390	174	20	.	.	PROPN
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admet-390	174	22	,	,	PUNCT
admet-390	174	23	y.	y.	PROPN
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admet-390	174	32	(	(	PUNCT
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admet-390	174	34	)	)	PUNCT
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admet-390	174	36	-	-	SYM
admet-390	174	37	373	373	NUM
admet-390	174	38	.	.	PUNCT
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admet-390	175	3	]	]	X
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admet-390	175	7	s.	s.	PROPN
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admet-390	175	9	,	,	PUNCT
admet-390	175	10	a.	a.	PROPN
admet-390	175	11	lee	lee	PROPN
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admet-390	175	13	s.h	s.h	PROPN
admet-390	175	14	.	.	PROPN
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admet-390	175	33	(	(	PUNCT
admet-390	175	34	2010	2010	NUM
admet-390	175	35	)	)	PUNCT
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admet-390	175	37	-	-	SYM
admet-390	175	38	4519	4519	NUM
admet-390	175	39	.	.	PUNCT
admet-390	176	1	[	[	X
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admet-390	176	3	]	]	PUNCT
admet-390	176	4	q.	q.	PROPN
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admet-390	176	7	y.	y.	PROPN
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admet-390	176	10	y.	y.	PROPN
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admet-390	176	13	t.	t.	PROPN
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admet-390	176	23	(	(	PUNCT
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admet-390	176	25	)	)	PUNCT
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admet-390	176	27	-	-	SYM
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admet-390	176	29	.	.	PUNCT
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admet-390	177	2	32	32	NUM
admet-390	177	3	]	]	X
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admet-390	177	8	.	.	PROPN
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admet-390	177	10	,	,	PUNCT
admet-390	177	11	m.s	m.s	PROPN
admet-390	177	12	.	.	PROPN
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admet-390	177	19	toxicity	toxicity	NOUN
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admet-390	177	21	11	11	NUM
admet-390	177	22	,	,	PUNCT
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admet-390	177	26	,	,	PUNCT
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admet-390	177	28	,	,	PUNCT
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admet-390	177	31	-	-	SYM
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admet-390	177	33	.	.	PUNCT
admet-390	178	1	[	[	X
admet-390	178	2	33	33	NUM
admet-390	178	3	]	]	SYM
admet-390	178	4	f.g.m	f.g.m	NOUN
admet-390	178	5	.	.	PUNCT
admet-390	179	1	russel	russel	NOUN
admet-390	179	2	,	,	PUNCT
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admet-390	179	4	and	and	CCONJ
admet-390	179	5	transporter	transporter	NOUN
admet-390	179	6	-	-	PUNCT
admet-390	179	7	based	base	VERB
admet-390	179	8	drug	drug	NOUN
admet-390	179	9	-	-	PUNCT
admet-390	179	10	drug	drug	NOUN
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admet-390	179	12	.	.	PUNCT
admet-390	180	1	progress	progress	NOUN
admet-390	180	2	and	and	CCONJ
admet-390	180	3	future	future	ADJ
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admet-390	180	5	.	.	PUNCT
admet-390	181	1	pang	pang	NOUN
admet-390	181	2	,	,	PUNCT
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admet-390	181	4	,	,	PUNCT
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admet-390	181	9	r.m	r.m	PROPN
admet-390	181	10	.	.	PROPN
admet-390	181	11	(	(	PUNCT
admet-390	181	12	eds	ed	NOUN
admet-390	181	13	)	)	PUNCT
admet-390	181	14	.	.	PUNCT
admet-390	182	1	2010	2010	NUM
admet-390	182	2	,	,	PUNCT
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admet-390	182	4	.	.	PUNCT
admet-390	183	1	[	[	X
admet-390	183	2	34	34	NUM
admet-390	183	3	]	]	X
admet-390	183	4	guideline	guideline	NOUN
admet-390	183	5	on	on	ADP
admet-390	183	6	the	the	DET
admet-390	183	7	investigation	investigation	NOUN
admet-390	183	8	of	of	ADP
admet-390	183	9	drug	drug	NOUN
admet-390	183	10	interactions	interaction	NOUN
admet-390	183	11	ema	ema	PROPN
admet-390	183	12	,	,	PUNCT
admet-390	183	13	cpmp	cpmp	PROPN
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admet-390	183	15	ewp/560/95	ewp/560/95	NOUN
admet-390	183	16	rev.1	rev.1	PROPN
admet-390	183	17	june	june	PROPN
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admet-390	183	19	.	.	PUNCT
admet-390	184	1	[	[	X
admet-390	184	2	35	35	NUM
admet-390	184	3	]	]	SYM
admet-390	184	4	guidance	guidance	NOUN
admet-390	184	5	for	for	ADP
admet-390	184	6	industry	industry	NOUN
admet-390	184	7	.	.	PUNCT
admet-390	185	1	drug	drug	NOUN
admet-390	185	2	interaction	interaction	NOUN
admet-390	185	3	studies	study	NOUN
admet-390	185	4	.	.	PUNCT
admet-390	186	1	studies	study	NOUN
admet-390	186	2	design	design	VERB
admet-390	186	3	,	,	PUNCT
admet-390	186	4	data	datum	NOUN
admet-390	186	5	analysis	analysis	NOUN
admet-390	186	6	,	,	PUNCT
admet-390	186	7	implications	implication	NOUN
admet-390	186	8	for	for	ADP
admet-390	186	9	dosing	dose	VERB
admet-390	186	10	and	and	CCONJ
admet-390	186	11	labeling	labeling	NOUN
admet-390	186	12	recommendations	recommendation	NOUN
admet-390	186	13	fda	fda	PROPN
admet-390	186	14	,	,	PUNCT
admet-390	186	15	cder	cder	NOUN
admet-390	186	16	,	,	PUNCT
admet-390	186	17	feb	feb	PROPN
admet-390	186	18	2012	2012	NUM
admet-390	186	19	.	.	PUNCT
admet-390	187	1	[	[	X
admet-390	187	2	36	36	NUM
admet-390	187	3	]	]	X
admet-390	187	4	m.h	m.h	PROPN
admet-390	187	5	.	.	PROPN
admet-390	187	6	brown	brown	PROPN
admet-390	187	7	,	,	PUNCT
admet-390	187	8	i.t	i.t	PROPN
admet-390	187	9	.	.	PROPN
admet-390	187	10	paulsen	paulsen	PROPN
admet-390	187	11	,	,	PUNCT
admet-390	187	12	r.a	r.a	PROPN
admet-390	187	13	.	.	PROPN
admet-390	187	14	skurray	skurray	PROPN
admet-390	187	15	,	,	PUNCT
admet-390	187	16	molecular	molecular	ADJ
admet-390	187	17	microbiology	microbiology	NOUN
admet-390	187	18	,	,	PUNCT
admet-390	187	19	31	31	NUM
admet-390	187	20	(	(	PUNCT
admet-390	187	21	1999	1999	NUM
admet-390	187	22	)	)	PUNCT
admet-390	187	23	394	394	NUM
admet-390	187	24	-	-	SYM
admet-390	187	25	395	395	NUM
admet-390	187	26	.	.	PUNCT
admet-390	188	1	[	[	X
admet-390	188	2	37	37	NUM
admet-390	188	3	]	]	PUNCT
admet-390	188	4	h.	h.	PROPN
admet-390	188	5	omote	omote	PROPN
admet-390	188	6	,	,	PUNCT
admet-390	188	7	m.	m.	NOUN
admet-390	188	8	hiasa	hiasa	NOUN
admet-390	188	9	,	,	PUNCT
admet-390	188	10	t.	t.	PROPN
admet-390	188	11	matsumoto	matsumoto	PROPN
admet-390	188	12	,	,	PUNCT
admet-390	188	13	m.	m.	NOUN
admet-390	188	14	otsuka	otsuka	PROPN
admet-390	188	15	,	,	PUNCT
admet-390	188	16	y.	y.	PROPN
admet-390	188	17	moriyama	moriyama	PROPN
admet-390	188	18	,	,	PUNCT
admet-390	188	19	trends	trend	NOUN
admet-390	188	20	in	in	ADP
admet-390	188	21	pharmacological	pharmacological	ADJ
admet-390	188	22	sciences	science	NOUN
admet-390	188	23	,	,	PUNCT
admet-390	188	24	27	27	NUM
admet-390	188	25	(	(	PUNCT
admet-390	188	26	2006	2006	NUM
admet-390	188	27	)	)	PUNCT
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admet-390	188	29	-	-	SYM
admet-390	188	30	593	593	NUM
admet-390	188	31	.	.	PUNCT
admet-390	189	1	[	[	X
admet-390	189	2	38	38	NUM
admet-390	189	3	]	]	PUNCT
admet-390	189	4	m.	m.	NOUN
admet-390	189	5	otsuka	otsuka	PROPN
admet-390	189	6	,	,	PUNCT
admet-390	189	7	t.	t.	PROPN
admet-390	189	8	matsumoto	matsumoto	PROPN
admet-390	189	9	,	,	PUNCT
admet-390	189	10	r.	r.	PROPN
admet-390	189	11	morimoto	morimoto	PROPN
admet-390	189	12	,	,	PUNCT
admet-390	189	13	s.	s.	PROPN
admet-390	189	14	arioka	arioka	PROPN
admet-390	189	15	,	,	PUNCT
admet-390	189	16	h.	h.	PROPN
admet-390	189	17	omote	omote	PROPN
admet-390	189	18	,	,	PUNCT
admet-390	189	19	y.	y.	PROPN
admet-390	189	20	moriyama	moriyama	PROPN
admet-390	189	21	,	,	PUNCT
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admet-390	189	23	of	of	ADP
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admet-390	189	25	national	national	PROPN
admet-390	189	26	academy	academy	PROPN
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admet-390	189	28	sciences	sciences	PROPN
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admet-390	189	30	,	,	PUNCT
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admet-390	189	32	(	(	PUNCT
admet-390	189	33	2005	2005	NUM
admet-390	189	34	)	)	PUNCT
admet-390	189	35	,	,	PUNCT
admet-390	189	36	17923	17923	NUM
admet-390	189	37	-	-	SYM
admet-390	189	38	17928	17928	NUM
admet-390	189	39	.	.	PUNCT
admet-390	190	1	[	[	X
admet-390	190	2	39	39	NUM
admet-390	190	3	]	]	PUNCT
admet-390	190	4	m.	m.	NOUN
admet-390	190	5	hias	hias	PROPN
admet-390	190	6	,	,	PUNCT
admet-390	190	7	t.	t.	PROPN
admet-390	190	8	matsumoto	matsumoto	PROPN
admet-390	190	9	,	,	PUNCT
admet-390	190	10	t.	t.	PROPN
admet-390	190	11	komatsu	komatsu	PROPN
admet-390	190	12	,	,	PUNCT
admet-390	190	13	y.	y.	PROPN
admet-390	190	14	moriyama	moriyama	PROPN
admet-390	190	15	,	,	PUNCT
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admet-390	190	17	journal	journal	PROPN
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admet-390	190	22	,	,	PUNCT
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admet-390	190	24	(	(	PUNCT
admet-390	190	25	2006	2006	NUM
admet-390	190	26	)	)	PUNCT
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admet-390	190	28	-	-	SYM
admet-390	190	29	686	686	NUM
admet-390	190	30	.	.	PUNCT
admet-390	191	1	[	[	X
admet-390	191	2	40	40	NUM
admet-390	191	3	]	]	PUNCT
admet-390	191	4	a.	a.	NOUN
admet-390	191	5	slominski	slominski	PROPN
admet-390	191	6	,	,	PUNCT
admet-390	191	7	j.	j.	PROPN
admet-390	191	8	wortsman	wortsman	PROPN
admet-390	191	9	,	,	PUNCT
admet-390	191	10	endocrine	endocrine	NOUN
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admet-390	191	12	,	,	PUNCT
admet-390	191	13	21	21	NUM
admet-390	191	14	(	(	PUNCT
admet-390	191	15	2000	2000	NUM
admet-390	191	16	)	)	PUNCT
admet-390	191	17	457	457	NUM
admet-390	191	18	-	-	SYM
admet-390	191	19	487	487	NUM
admet-390	191	20	.	.	PUNCT
admet-390	192	1	[	[	X
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admet-390	192	3	]	]	X
admet-390	192	4	s.	s.	PROPN
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admet-390	192	6	,	,	PUNCT
admet-390	192	7	o.	o.	PROPN
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admet-390	192	9	,	,	PUNCT
admet-390	192	10	h.	h.	PROPN
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admet-390	192	12	,	,	PUNCT
admet-390	192	13	t.	t.	PROPN
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admet-390	192	15	,	,	PUNCT
admet-390	192	16	s.	s.	PROPN
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admet-390	192	18	,	,	PUNCT
admet-390	192	19	a.	a.	PROPN
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admet-390	192	21	,	,	PUNCT
admet-390	192	22	n.	n.	PROPN
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admet-390	192	24	,	,	PUNCT
admet-390	192	25	w.	w.	PROPN
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admet-390	192	30	-	-	PUNCT
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admet-390	192	33	t.	t.	PROPN
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admet-390	192	36	t.	t.	PROPN
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admet-390	192	42	,	,	PUNCT
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admet-390	192	44	(	(	PUNCT
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admet-390	192	46	)	)	PUNCT
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admet-390	192	48	-	-	SYM
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admet-390	192	50	.	.	PUNCT
admet-390	193	1	[	[	X
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admet-390	193	3	]	]	PUNCT
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admet-390	193	9	,	,	PUNCT
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admet-390	193	14	.	.	PROPN
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admet-390	193	20	s.	s.	PROPN
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admet-390	193	22	,	,	PUNCT
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admet-390	193	24	.	.	PROPN
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admet-390	193	26	,	,	PUNCT
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admet-390	193	28	.	.	PROPN
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admet-390	193	30	,	,	PUNCT
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admet-390	193	34	,	,	PUNCT
admet-390	193	35	42	42	NUM
admet-390	193	36	(	(	PUNCT
admet-390	193	37	2014	2014	NUM
admet-390	193	38	)	)	PUNCT
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admet-390	193	40	-	-	SYM
admet-390	193	41	88	88	NUM
admet-390	193	42	.	.	PUNCT
admet-390	194	1	[	[	X
admet-390	194	2	43	43	NUM
admet-390	194	3	]	]	PUNCT
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admet-390	194	7	b.	b.	PROPN
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admet-390	194	9	,	,	PUNCT
admet-390	194	10	l.	l.	PROPN
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admet-390	194	12	,	,	PUNCT
admet-390	194	13	x.	x.	PROPN
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admet-390	194	16	a.	a.	PROPN
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admet-390	194	25	,	,	PUNCT
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admet-390	194	35	(	(	PUNCT
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admet-390	194	37	)	)	PUNCT
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admet-390	194	39	-	-	SYM
admet-390	194	40	374	374	NUM
admet-390	194	41	.	.	PUNCT
admet-390	195	1	h.	h.	PROPN
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admet-390	195	12	)	)	PUNCT
admet-390	195	13	(	(	PUNCT
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admet-390	195	15	)	)	PUNCT
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admet-390	195	17	-	-	SYM
admet-390	195	18	84	84	NUM
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admet-390	195	22	]	]	PUNCT
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admet-390	195	29	s.	s.	PROPN
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admet-390	195	31	,	,	PUNCT
admet-390	195	32	c.	c.	PROPN
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admet-390	195	38	,	,	PUNCT
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admet-390	195	42	,	,	PUNCT
admet-390	195	43	e.j	e.j	PROPN
admet-390	195	44	.	.	PROPN
admet-390	195	45	kelly	kelly	PROPN
admet-390	195	46	,	,	PUNCT
admet-390	195	47	j.	j.	PROPN
admet-390	195	48	himmelfarb	himmelfarb	PROPN
admet-390	195	49	,	,	PUNCT
admet-390	195	50	j.d	j.d	PROPN
admet-390	195	51	.	.	PROPN
admet-390	195	52	unadkat	unadkat	PROPN
admet-390	195	53	,	,	PUNCT
admet-390	195	54	drug	drug	NOUN
admet-390	195	55	metab	metab	PROPN
admet-390	195	56	dispos	dispos	PROPN
admet-390	195	57	,	,	PUNCT
admet-390	195	58	44	44	NUM
admet-390	195	59	(	(	PUNCT
admet-390	195	60	2016	2016	NUM
admet-390	195	61	)	)	PUNCT
admet-390	195	62	1920	1920	NUM
admet-390	195	63	-	-	SYM
admet-390	195	64	1924	1924	NUM
admet-390	195	65	.	.	PUNCT
admet-390	196	1	[	[	X
admet-390	196	2	45	45	NUM
admet-390	196	3	]	]	X
admet-390	196	4	h.j	h.j	PROPN
admet-390	196	5	.	.	PROPN
admet-390	196	6	burt	burt	PROPN
admet-390	196	7	,	,	PUNCT
admet-390	196	8	a.e	a.e	PROPN
admet-390	196	9	.	.	PROPN
admet-390	196	10	riedmaier	riedmaier	NOUN
admet-390	196	11	,	,	PUNCT
admet-390	196	12	m.d	m.d	PROPN
admet-390	196	13	.	.	PROPN
admet-390	196	14	harwood	harwood	PROPN
admet-390	196	15	,	,	PUNCT
admet-390	196	16	h.k.crewe	h.k.crewe	PROPN
admet-390	196	17	,	,	PUNCT
admet-390	196	18	k.l	k.l	PROPN
admet-390	196	19	.	.	PROPN
admet-390	196	20	gill	gill	PROPN
admet-390	196	21	,	,	PUNCT
admet-390	196	22	s.	s.	PROPN
admet-390	196	23	neuhoff	neuhoff	PROPN
admet-390	196	24	,	,	PUNCT
admet-390	196	25	drug	drug	NOUN
admet-390	196	26	metab	metab	PROPN
admet-390	196	27	dispos	dispos	PROPN
admet-390	196	28	,	,	PUNCT
admet-390	196	29	44	44	NUM
admet-390	196	30	(	(	PUNCT
admet-390	196	31	2016	2016	NUM
admet-390	196	32	)	)	PUNCT
admet-390	196	33	1550	1550	NUM
admet-390	196	34	-	-	SYM
admet-390	196	35	1561	1561	NUM
admet-390	196	36	.	.	PUNCT
admet-390	197	1	©	©	PROPN
admet-390	197	2	2017	2017	NUM
admet-390	197	3	by	by	ADP
admet-390	197	4	the	the	DET
admet-390	197	5	authors	author	NOUN
admet-390	197	6	;	;	PUNCT
admet-390	197	7	licensee	licensee	PROPN
admet-390	197	8	iapc	iapc	PROPN
admet-390	197	9	,	,	PUNCT
admet-390	197	10	zagreb	zagreb	PROPN
admet-390	197	11	,	,	PUNCT
admet-390	197	12	croatia	croatia	PROPN
admet-390	197	13	.	.	PUNCT
admet-390	198	1	this	this	DET
admet-390	198	2	article	article	NOUN
admet-390	198	3	is	be	AUX
admet-390	198	4	an	an	DET
admet-390	198	5	open	open	ADJ
admet-390	198	6	-	-	PUNCT
admet-390	198	7	access	access	NOUN
admet-390	198	8	article	article	NOUN
admet-390	198	9	distributed	distribute	VERB
admet-390	198	10	under	under	ADP
admet-390	198	11	the	the	DET
admet-390	198	12	terms	term	NOUN
admet-390	198	13	and	and	CCONJ
admet-390	198	14	conditions	condition	NOUN
admet-390	198	15	of	of	ADP
admet-390	198	16	the	the	DET
admet-390	198	17	creative	creative	ADJ
admet-390	198	18	commons	common	NOUN
admet-390	198	19	attribution	attribution	NOUN
admet-390	198	20	license	license	NOUN
admet-390	198	21	(	(	PUNCT
admet-390	198	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-390	198	23	)	)	PUNCT
admet-390	198	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN