id	sid	tid	token	lemma	pos
admet-394	1	1	the	the	DET
admet-394	1	2	tales	tale	NOUN
admet-394	1	3	of	of	ADP
admet-394	1	4	two	two	NUM
admet-394	1	5	organic	organic	ADJ
admet-394	1	6	cation	cation	NOUN
admet-394	1	7	transporters	transporter	NOUN
admet-394	1	8	,	,	PUNCT
admet-394	1	9	oct-1	oct-1	NUM
admet-394	1	10	and	and	CCONJ
admet-394	1	11	oct-2	oct-2	NUM
admet-394	1	12	,	,	PUNCT
admet-394	1	13	in	in	ADP
admet-394	1	14	caenorhabditis	caenorhabditis	PROPN
admet-394	1	15	elegans	elegan	NOUN
admet-394	1	16	doi	doi	NOUN
admet-394	1	17	:	:	PUNCT
admet-394	1	18	10.5599	10.5599	NUM
admet-394	1	19	/	/	SYM
admet-394	1	20	admet.5.3.394	admet.5.3.394	X
admet-394	1	21	146	146	NUM
admet-394	1	22	admet	admet	X
admet-394	1	23	&	&	CCONJ
admet-394	1	24	dmpk	dmpk	PROPN
admet-394	1	25	5(3	5(3	NUM
admet-394	1	26	)	)	PUNCT
admet-394	1	27	(	(	PUNCT
admet-394	1	28	2017	2017	NUM
admet-394	1	29	)	)	PUNCT
admet-394	1	30	146	146	NUM
admet-394	1	31	-	-	SYM
admet-394	1	32	158	158	NUM
admet-394	1	33	;	;	PUNCT
admet-394	1	34	doi	doi	NOUN
admet-394	1	35	:	:	PUNCT
admet-394	1	36	http://dx.doi.org/10.5599/admet.5.3.394	http://dx.doi.org/10.5599/admet.5.3.394	NOUN
admet-394	1	37	open	open	ADJ
admet-394	1	38	access	access	NOUN
admet-394	1	39	:	:	PUNCT
admet-394	1	40	issn	issn	PROPN
admet-394	1	41	:	:	PUNCT
admet-394	1	42	1848	1848	NUM
admet-394	1	43	-	-	SYM
admet-394	1	44	7718	7718	NUM
admet-394	1	45	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-394	1	46	review	review	VERB
admet-394	1	47	the	the	DET
admet-394	1	48	tales	tale	NOUN
admet-394	1	49	of	of	ADP
admet-394	1	50	two	two	NUM
admet-394	1	51	organic	organic	ADJ
admet-394	1	52	cation	cation	NOUN
admet-394	1	53	transporters	transporter	NOUN
admet-394	1	54	,	,	PUNCT
admet-394	1	55	oct-1	oct-1	NUM
admet-394	1	56	and	and	CCONJ
admet-394	1	57	oct-2	oct-2	NUM
admet-394	1	58	,	,	PUNCT
admet-394	1	59	in	in	ADP
admet-394	1	60	caenorhabditis	caenorhabditis	PROPN
admet-394	1	61	elegans	elegan	NOUN
admet-394	1	62	dindial	dindial	ADJ
admet-394	1	63	ramotar	ramotar	PROPN
admet-394	1	64	maisonneuve	maisonneuve	NOUN
admet-394	1	65	-	-	PUNCT
admet-394	1	66	rosemont	rosemont	NOUN
admet-394	1	67	hospital	hospital	NOUN
admet-394	1	68	research	research	NOUN
admet-394	1	69	center	center	NOUN
admet-394	1	70	,	,	PUNCT
admet-394	1	71	and	and	CCONJ
admet-394	1	72	the	the	DET
admet-394	1	73	université	université	PROPN
admet-394	1	74	de	de	PROPN
admet-394	1	75	montréal	montréal	PROPN
admet-394	1	76	,	,	PUNCT
admet-394	1	77	faculty	faculty	NOUN
admet-394	1	78	of	of	ADP
admet-394	1	79	medicine	medicine	NOUN
admet-394	1	80	,	,	PUNCT
admet-394	1	81	department	department	NOUN
admet-394	1	82	of	of	ADP
admet-394	1	83	medicine	medicine	NOUN
admet-394	1	84	,	,	PUNCT
admet-394	1	85	montréal	montréal	PROPN
admet-394	1	86	,	,	PUNCT
admet-394	1	87	quebec	quebec	PROPN
admet-394	1	88	,	,	PUNCT
admet-394	1	89	canada	canada	PROPN
admet-394	1	90	.	.	PUNCT
admet-394	2	1	*	*	PUNCT
admet-394	2	2	corresponding	correspond	VERB
admet-394	2	3	author	author	NOUN
admet-394	2	4	:	:	PUNCT
admet-394	2	5	e	e	NOUN
admet-394	2	6	-	-	NOUN
admet-394	2	7	mail	mail	NOUN
admet-394	2	8	:	:	PUNCT
admet-394	2	9	dindial.ramotar@umontreal.ca	dindial.ramotar@umontreal.ca	ADV
admet-394	2	10	;	;	PUNCT
admet-394	2	11	tel	tel	PROPN
admet-394	2	12	.	.	PROPN
admet-394	2	13	:	:	PUNCT
admet-394	2	14	(	(	PUNCT
admet-394	2	15	514	514	NUM
admet-394	2	16	)	)	PUNCT
admet-394	2	17	252	252	NUM
admet-394	2	18	-	-	SYM
admet-394	2	19	3400	3400	NUM
admet-394	2	20	ext	ext	NOUN
admet-394	2	21	.	.	PROPN
admet-394	2	22	4684	4684	NUM
admet-394	2	23	;	;	PUNCT
admet-394	2	24	fax	fax	NOUN
admet-394	2	25	:	:	PUNCT
admet-394	2	26	(	(	PUNCT
admet-394	2	27	514	514	NUM
admet-394	2	28	)	)	NUM
admet-394	2	29	252	252	NUM
admet-394	2	30	-	-	SYM
admet-394	2	31	3430	3430	NUM
admet-394	2	32	received	receive	VERB
admet-394	2	33	:	:	PUNCT
admet-394	2	34	may	may	AUX
admet-394	2	35	25	25	NUM
admet-394	2	36	,	,	PUNCT
admet-394	2	37	2017	2017	NUM
admet-394	2	38	;	;	PUNCT
admet-394	2	39	revised	revise	VERB
admet-394	2	40	:	:	PUNCT
admet-394	2	41	july	july	PROPN
admet-394	2	42	13	13	NUM
admet-394	2	43	,	,	PUNCT
admet-394	2	44	2017	2017	NUM
admet-394	2	45	;	;	PUNCT
admet-394	2	46	published	publish	VERB
admet-394	2	47	:	:	PUNCT
admet-394	2	48	september	september	PROPN
admet-394	2	49	29	29	NUM
admet-394	2	50	,	,	PUNCT
admet-394	2	51	2017	2017	NUM
admet-394	2	52	abstract	abstract	ADJ
admet-394	2	53	solute	solute	NOUN
admet-394	2	54	carrier	carrier	NOUN
admet-394	2	55	transporters	transporter	NOUN
admet-394	2	56	,	,	PUNCT
admet-394	2	57	previously	previously	ADV
admet-394	2	58	thought	think	VERB
admet-394	2	59	to	to	PART
admet-394	2	60	perform	perform	VERB
admet-394	2	61	roles	role	NOUN
admet-394	2	62	in	in	ADP
admet-394	2	63	the	the	DET
admet-394	2	64	transport	transport	NOUN
admet-394	2	65	of	of	ADP
admet-394	2	66	ions	ion	NOUN
admet-394	2	67	and	and	CCONJ
admet-394	2	68	various	various	ADJ
admet-394	2	69	nutrients	nutrient	NOUN
admet-394	2	70	are	be	AUX
admet-394	2	71	now	now	ADV
admet-394	2	72	assigned	assign	VERB
admet-394	2	73	broader	broad	ADJ
admet-394	2	74	functions	function	NOUN
admet-394	2	75	.	.	PUNCT
admet-394	3	1	these	these	DET
admet-394	3	2	transporters	transporter	NOUN
admet-394	3	3	have	have	AUX
admet-394	3	4	recently	recently	ADV
admet-394	3	5	been	be	AUX
admet-394	3	6	shown	show	VERB
admet-394	3	7	to	to	PART
admet-394	3	8	permit	permit	VERB
admet-394	3	9	entry	entry	NOUN
admet-394	3	10	of	of	ADP
admet-394	3	11	therapeutic	therapeutic	ADJ
admet-394	3	12	drugs	drug	NOUN
admet-394	3	13	into	into	ADP
admet-394	3	14	cells	cell	NOUN
admet-394	3	15	.	.	PUNCT
admet-394	4	1	there	there	PRON
admet-394	4	2	is	be	VERB
admet-394	4	3	growing	grow	VERB
admet-394	4	4	interest	interest	NOUN
admet-394	4	5	to	to	PART
admet-394	4	6	understand	understand	VERB
admet-394	4	7	the	the	DET
admet-394	4	8	broad	broad	ADJ
admet-394	4	9	spectrum	spectrum	NOUN
admet-394	4	10	of	of	ADP
admet-394	4	11	drugs	drug	NOUN
admet-394	4	12	and	and	CCONJ
admet-394	4	13	chemical	chemical	NOUN
admet-394	4	14	compounds	compound	NOUN
admet-394	4	15	that	that	PRON
admet-394	4	16	are	be	AUX
admet-394	4	17	recognized	recognize	VERB
admet-394	4	18	by	by	ADP
admet-394	4	19	these	these	DET
admet-394	4	20	transporters	transporter	NOUN
admet-394	4	21	such	such	ADJ
admet-394	4	22	that	that	PRON
admet-394	4	23	specific	specific	ADJ
admet-394	4	24	ligands	ligand	NOUN
admet-394	4	25	can	can	AUX
admet-394	4	26	be	be	AUX
admet-394	4	27	used	use	VERB
admet-394	4	28	as	as	ADP
admet-394	4	29	therapeutics	therapeutic	NOUN
admet-394	4	30	to	to	PART
admet-394	4	31	target	target	VERB
admet-394	4	32	definite	definite	ADJ
admet-394	4	33	physiological	physiological	ADJ
admet-394	4	34	pathways	pathway	NOUN
admet-394	4	35	.	.	PUNCT
admet-394	5	1	to	to	PART
admet-394	5	2	facilitate	facilitate	VERB
admet-394	5	3	this	this	DET
admet-394	5	4	investigation	investigation	NOUN
admet-394	5	5	,	,	PUNCT
admet-394	5	6	simpler	simple	ADJ
admet-394	5	7	and	and	CCONJ
admet-394	5	8	cost	cost	VERB
admet-394	5	9	effective	effective	ADJ
admet-394	5	10	model	model	NOUN
admet-394	5	11	systems	system	NOUN
admet-394	5	12	are	be	AUX
admet-394	5	13	needed	need	VERB
admet-394	5	14	,	,	PUNCT
admet-394	5	15	one	one	NUM
admet-394	5	16	of	of	ADP
admet-394	5	17	such	such	ADJ
admet-394	5	18	is	be	AUX
admet-394	5	19	the	the	DET
admet-394	5	20	live	live	ADJ
admet-394	5	21	whole	whole	ADJ
admet-394	5	22	model	model	NOUN
admet-394	5	23	animal	animal	NOUN
admet-394	5	24	caenorhabditis	caenorhabditis	NOUN
admet-394	5	25	elegans	elegan	NOUN
admet-394	5	26	(	(	PUNCT
admet-394	5	27	c.	c.	NOUN
admet-394	5	28	elegans	elegans	PROPN
admet-394	5	29	)	)	PUNCT
admet-394	5	30	that	that	PRON
admet-394	5	31	offers	offer	VERB
admet-394	5	32	a	a	DET
admet-394	5	33	multitude	multitude	NOUN
admet-394	5	34	of	of	ADP
admet-394	5	35	advantages	advantage	NOUN
admet-394	5	36	.	.	PUNCT
admet-394	6	1	in	in	ADP
admet-394	6	2	general	general	ADJ
admet-394	6	3	,	,	PUNCT
admet-394	6	4	studies	study	NOUN
admet-394	6	5	with	with	ADP
admet-394	6	6	c.	c.	PROPN
admet-394	6	7	elegans	elegan	NOUN
admet-394	6	8	are	be	AUX
admet-394	6	9	feasible	feasible	ADJ
admet-394	6	10	due	due	ADP
admet-394	6	11	to	to	ADP
admet-394	6	12	the	the	DET
admet-394	6	13	simplicity	simplicity	NOUN
admet-394	6	14	of	of	ADP
admet-394	6	15	the	the	DET
admet-394	6	16	readouts	readout	NOUN
admet-394	6	17	that	that	PRON
admet-394	6	18	include	include	VERB
admet-394	6	19	lifespan	lifespan	NOUN
admet-394	6	20	,	,	PUNCT
admet-394	6	21	brood	brood	NOUN
admet-394	6	22	size	size	NOUN
admet-394	6	23	,	,	PUNCT
admet-394	6	24	germ	germ	NOUN
admet-394	6	25	cell	cell	NOUN
admet-394	6	26	death	death	NOUN
admet-394	6	27	,	,	PUNCT
admet-394	6	28	and	and	CCONJ
admet-394	6	29	visualization	visualization	NOUN
admet-394	6	30	by	by	ADP
admet-394	6	31	epifluorescent	epifluorescent	ADJ
admet-394	6	32	microscopy	microscopy	NOUN
admet-394	6	33	,	,	PUNCT
admet-394	6	34	which	which	PRON
admet-394	6	35	can	can	AUX
admet-394	6	36	be	be	AUX
admet-394	6	37	set	set	VERB
admet-394	6	38	up	up	ADP
admet-394	6	39	in	in	ADP
admet-394	6	40	any	any	DET
admet-394	6	41	laboratory	laboratory	NOUN
admet-394	6	42	.	.	PUNCT
admet-394	7	1	in	in	ADP
admet-394	7	2	c.	c.	PROPN
admet-394	7	3	elegans	elegans	PROPN
admet-394	7	4	,	,	PUNCT
admet-394	7	5	two	two	NUM
admet-394	7	6	solute	solute	ADJ
admet-394	7	7	carrier	carrier	NOUN
admet-394	7	8	transporters	transporter	NOUN
admet-394	7	9	,	,	PUNCT
admet-394	7	10	the	the	DET
admet-394	7	11	organic	organic	ADJ
admet-394	7	12	cation	cation	NOUN
admet-394	7	13	transporters	transporter	NOUN
admet-394	7	14	oct-1	oct-1	NUM
admet-394	7	15	and	and	CCONJ
admet-394	7	16	its	its	PRON
admet-394	7	17	paralogue	paralogue	NOUN
admet-394	7	18	oct-2	oct-2	VERB
admet-394	7	19	have	have	AUX
admet-394	7	20	been	be	AUX
admet-394	7	21	partially	partially	ADV
admet-394	7	22	characterized	characterize	VERB
admet-394	7	23	.	.	PUNCT
admet-394	8	1	oct-1	oct-1	PUNCT
admet-394	8	2	mutants	mutant	NOUN
admet-394	8	3	display	display	VERB
admet-394	8	4	a	a	DET
admet-394	8	5	significantly	significantly	ADV
admet-394	8	6	reduced	reduce	VERB
admet-394	8	7	lifespan	lifespan	NOUN
admet-394	8	8	and	and	CCONJ
admet-394	8	9	brood	brood	NOUN
admet-394	8	10	size	size	NOUN
admet-394	8	11	,	,	PUNCT
admet-394	8	12	as	as	ADV
admet-394	8	13	well	well	ADV
admet-394	8	14	as	as	ADP
admet-394	8	15	exhibiting	exhibit	VERB
admet-394	8	16	an	an	DET
admet-394	8	17	increased	increase	VERB
admet-394	8	18	susceptibility	susceptibility	NOUN
admet-394	8	19	towards	towards	ADP
admet-394	8	20	oxidative	oxidative	ADJ
admet-394	8	21	stress	stress	NOUN
admet-394	8	22	and	and	CCONJ
admet-394	8	23	a	a	DET
admet-394	8	24	subset	subset	NOUN
admet-394	8	25	of	of	ADP
admet-394	8	26	dna	dna	NOUN
admet-394	8	27	damaging	damaging	ADJ
admet-394	8	28	agents	agent	NOUN
admet-394	8	29	.	.	PUNCT
admet-394	9	1	these	these	DET
admet-394	9	2	multiple	multiple	ADJ
admet-394	9	3	phenotypes	phenotype	NOUN
admet-394	9	4	are	be	AUX
admet-394	9	5	directly	directly	ADV
admet-394	9	6	linked	link	VERB
admet-394	9	7	to	to	ADP
admet-394	9	8	oct-1	oct-1	ADV
admet-394	9	9	depletion	depletion	NOUN
admet-394	9	10	causing	cause	VERB
admet-394	9	11	upregulation	upregulation	NOUN
admet-394	9	12	of	of	ADP
admet-394	9	13	oct-2	oct-2	NUM
admet-394	9	14	,	,	PUNCT
admet-394	9	15	as	as	ADP
admet-394	9	16	rnai	rnai	NOUN
admet-394	9	17	-	-	PUNCT
admet-394	9	18	mediated	mediate	VERB
admet-394	9	19	downregulation	downregulation	NOUN
admet-394	9	20	of	of	ADP
admet-394	9	21	oct-2	oct-2	NUM
admet-394	9	22	rescues	rescue	NOUN
admet-394	9	23	the	the	DET
admet-394	9	24	oct-1	oct-1	ADV
admet-394	9	25	mutant	mutant	ADJ
admet-394	9	26	phenotypes	phenotype	NOUN
admet-394	9	27	.	.	PUNCT
admet-394	10	1	thus	thus	ADV
admet-394	10	2	,	,	PUNCT
admet-394	10	3	in	in	ADP
admet-394	10	4	c.	c.	PROPN
admet-394	10	5	elegans	elegan	NOUN
admet-394	10	6	oct-1	oct-1	X
admet-394	10	7	exerts	exert	VERB
admet-394	10	8	control	control	NOUN
admet-394	10	9	onto	onto	ADP
admet-394	10	10	oct-2	oct-2	NOUN
admet-394	10	11	,	,	PUNCT
admet-394	10	12	and	and	CCONJ
admet-394	10	13	this	this	DET
admet-394	10	14	latter	latter	ADJ
admet-394	10	15	transporter	transporter	NOUN
admet-394	10	16	plays	play	VERB
admet-394	10	17	a	a	DET
admet-394	10	18	predominant	predominant	ADJ
admet-394	10	19	role	role	NOUN
admet-394	10	20	in	in	ADP
admet-394	10	21	the	the	DET
admet-394	10	22	uptake	uptake	NOUN
admet-394	10	23	of	of	ADP
admet-394	10	24	various	various	ADJ
admet-394	10	25	ligands	ligand	NOUN
admet-394	10	26	.	.	PUNCT
admet-394	11	1	we	we	PRON
admet-394	11	2	first	first	ADV
admet-394	11	3	showed	show	VERB
admet-394	11	4	that	that	SCONJ
admet-394	11	5	oct-2	oct-2	PUNCT
admet-394	11	6	can	can	AUX
admet-394	11	7	efficiently	efficiently	ADV
admet-394	11	8	mediate	mediate	VERB
admet-394	11	9	uptake	uptake	NOUN
admet-394	11	10	of	of	ADP
admet-394	11	11	the	the	DET
admet-394	11	12	widely	widely	ADV
admet-394	11	13	used	use	VERB
admet-394	11	14	anticancer	anticancer	NOUN
admet-394	11	15	drug	drug	NOUN
admet-394	11	16	doxorubicin	doxorubicin	VERB
admet-394	11	17	into	into	ADP
admet-394	11	18	the	the	DET
admet-394	11	19	animals	animal	NOUN
admet-394	11	20	,	,	PUNCT
admet-394	11	21	but	but	CCONJ
admet-394	11	22	prevented	prevent	VERB
admet-394	11	23	uptake	uptake	ADJ
admet-394	11	24	upon	upon	SCONJ
admet-394	11	25	its	its	PRON
admet-394	11	26	downregulation	downregulation	NOUN
admet-394	11	27	.	.	PUNCT
admet-394	12	1	additional	additional	ADJ
admet-394	12	2	ligands	ligand	NOUN
admet-394	12	3	of	of	ADP
admet-394	12	4	oct-2	oct-2	NUM
admet-394	12	5	including	include	VERB
admet-394	12	6	cisplatin	cisplatin	NOUN
admet-394	12	7	and	and	CCONJ
admet-394	12	8	camptothecin	camptothecin	NOUN
admet-394	12	9	were	be	AUX
admet-394	12	10	revealed	reveal	VERB
admet-394	12	11	by	by	ADP
admet-394	12	12	ligand	ligand	NOUN
admet-394	12	13	-	-	PUNCT
admet-394	12	14	docking	docking	NOUN
admet-394	12	15	prediction	prediction	NOUN
admet-394	12	16	studies	study	NOUN
admet-394	12	17	.	.	PUNCT
admet-394	13	1	these	these	DET
admet-394	13	2	analyses	analysis	NOUN
admet-394	13	3	generated	generate	VERB
admet-394	13	4	docking	docking	NOUN
admet-394	13	5	scores	score	NOUN
admet-394	13	6	indicating	indicate	VERB
admet-394	13	7	that	that	SCONJ
admet-394	13	8	oct-2	oct-2	PRON
admet-394	13	9	can	can	AUX
admet-394	13	10	make	make	VERB
admet-394	13	11	robust	robust	ADJ
admet-394	13	12	contact	contact	NOUN
admet-394	13	13	with	with	ADP
admet-394	13	14	a	a	DET
admet-394	13	15	number	number	NOUN
admet-394	13	16	of	of	ADP
admet-394	13	17	therapeutics	therapeutic	NOUN
admet-394	13	18	and	and	CCONJ
admet-394	13	19	anticancer	anticancer	NOUN
admet-394	13	20	drugs	drug	NOUN
admet-394	13	21	,	,	PUNCT
admet-394	13	22	as	as	ADV
admet-394	13	23	well	well	ADV
admet-394	13	24	as	as	ADP
admet-394	13	25	chemical	chemical	NOUN
admet-394	13	26	compounds	compound	NOUN
admet-394	13	27	that	that	PRON
admet-394	13	28	possess	possess	VERB
admet-394	13	29	the	the	DET
admet-394	13	30	ability	ability	NOUN
admet-394	13	31	to	to	PART
admet-394	13	32	target	target	VERB
admet-394	13	33	specific	specific	ADJ
admet-394	13	34	physiological	physiological	ADJ
admet-394	13	35	pathways	pathway	NOUN
admet-394	13	36	.	.	PUNCT
admet-394	14	1	several	several	ADJ
admet-394	14	2	of	of	ADP
admet-394	14	3	the	the	DET
admet-394	14	4	compounds	compound	NOUN
admet-394	14	5	displaying	display	VERB
admet-394	14	6	high	high	ADJ
admet-394	14	7	docking	docking	NOUN
admet-394	14	8	scores	score	NOUN
admet-394	14	9	with	with	ADP
admet-394	14	10	oct-2	oct-2	NUM
admet-394	14	11	were	be	AUX
admet-394	14	12	validated	validate	VERB
admet-394	14	13	and	and	CCONJ
admet-394	14	14	indeed	indeed	ADV
admet-394	14	15	found	find	VERB
admet-394	14	16	to	to	PART
admet-394	14	17	be	be	AUX
admet-394	14	18	substrates	substrate	NOUN
admet-394	14	19	that	that	SCONJ
admet-394	14	20	oct-2	oct-2	VERB
admet-394	14	21	transported	transport	VERB
admet-394	14	22	into	into	ADP
admet-394	14	23	the	the	DET
admet-394	14	24	animals	animal	NOUN
admet-394	14	25	.	.	PUNCT
admet-394	15	1	this	this	DET
admet-394	15	2	review	review	NOUN
admet-394	15	3	provides	provide	VERB
admet-394	15	4	an	an	DET
admet-394	15	5	insight	insight	NOUN
admet-394	15	6	how	how	SCONJ
admet-394	15	7	the	the	DET
admet-394	15	8	transporters	transporter	NOUN
admet-394	15	9	oct-1	oct-1	ADV
admet-394	15	10	and	and	CCONJ
admet-394	15	11	oct-2	oct-2	NUM
admet-394	15	12	of	of	ADP
admet-394	15	13	a	a	DET
admet-394	15	14	simple	simple	ADJ
admet-394	15	15	model	model	NOUN
admet-394	15	16	organism	organism	NOUN
admet-394	15	17	c.	c.	PROPN
admet-394	15	18	elegans	elegans	PROPN
admet-394	15	19	can	can	AUX
admet-394	15	20	be	be	AUX
admet-394	15	21	exploited	exploit	VERB
admet-394	15	22	to	to	PART
admet-394	15	23	report	report	VERB
admet-394	15	24	on	on	ADP
admet-394	15	25	the	the	DET
admet-394	15	26	cytotoxicities	cytotoxicity	NOUN
admet-394	15	27	and	and	CCONJ
admet-394	15	28	genotoxicities	genotoxicitie	NOUN
admet-394	15	29	of	of	ADP
admet-394	15	30	therapeutic	therapeutic	ADJ
admet-394	15	31	agents	agent	NOUN
admet-394	15	32	,	,	PUNCT
admet-394	15	33	as	as	ADV
admet-394	15	34	well	well	ADV
admet-394	15	35	as	as	ADP
admet-394	15	36	trace	trace	NOUN
admet-394	15	37	amounts	amount	NOUN
admet-394	15	38	of	of	ADP
admet-394	15	39	undocumented	undocumented	ADJ
admet-394	15	40	toxic	toxic	ADJ
admet-394	15	41	compounds	compound	NOUN
admet-394	15	42	with	with	ADP
admet-394	15	43	neoplastic	neoplastic	ADJ
admet-394	15	44	potentials	potential	NOUN
admet-394	15	45	that	that	PRON
admet-394	15	46	are	be	AUX
admet-394	15	47	present	present	ADJ
admet-394	15	48	in	in	ADP
admet-394	15	49	the	the	DET
admet-394	15	50	environment	environment	NOUN
admet-394	15	51	.	.	PUNCT
admet-394	16	1	keywords	keyword	VERB
admet-394	16	2	drug	drug	NOUN
admet-394	16	3	uptake	uptake	NOUN
admet-394	16	4	and	and	CCONJ
admet-394	16	5	resistance	resistance	NOUN
admet-394	16	6	;	;	PUNCT
admet-394	16	7	c.	c.	NOUN
admet-394	16	8	elegans	elegan	VERB
admet-394	16	9	organic	organic	ADJ
admet-394	16	10	cation	cation	NOUN
admet-394	16	11	transporters	transporter	NOUN
admet-394	16	12	;	;	PUNCT
admet-394	16	13	germ	germ	NOUN
admet-394	16	14	cells	cell	NOUN
admet-394	16	15	apoptosis	apoptosis	VERB
admet-394	16	16	;	;	PUNCT
admet-394	16	17	dna	dna	NOUN
admet-394	16	18	damage	damage	NOUN
admet-394	16	19	and	and	CCONJ
admet-394	16	20	repair	repair	VERB
admet-394	16	21	pathways	pathway	NOUN
admet-394	16	22	introduction	introduction	NOUN
admet-394	16	23	the	the	DET
admet-394	16	24	mainstay	mainstay	NOUN
admet-394	16	25	chemotherapeutics	chemotherapeutic	NOUN
admet-394	16	26	such	such	ADJ
admet-394	16	27	as	as	ADP
admet-394	16	28	anthracyclines	anthracycline	NOUN
admet-394	16	29	,	,	PUNCT
admet-394	16	30	cisplatin	cisplatin	NOUN
admet-394	16	31	and	and	CCONJ
admet-394	16	32	radiomimetic	radiomimetic	ADJ
admet-394	16	33	drugs	drug	NOUN
admet-394	16	34	are	be	AUX
admet-394	16	35	often	often	ADV
admet-394	16	36	used	use	VERB
admet-394	16	37	to	to	PART
admet-394	16	38	eliminate	eliminate	VERB
admet-394	16	39	cancer	cancer	NOUN
admet-394	16	40	cells	cell	NOUN
admet-394	16	41	and	and	CCONJ
admet-394	16	42	reduce	reduce	VERB
admet-394	16	43	the	the	DET
admet-394	16	44	burden	burden	NOUN
admet-394	16	45	of	of	ADP
admet-394	16	46	tumors	tumor	NOUN
admet-394	16	47	by	by	ADP
admet-394	16	48	inflicting	inflict	VERB
admet-394	16	49	damages	damage	NOUN
admet-394	16	50	to	to	ADP
admet-394	16	51	the	the	DET
admet-394	16	52	genome	genome	NOUN
admet-394	17	1	[	[	X
admet-394	17	2	1	1	NUM
admet-394	17	3	-	-	SYM
admet-394	17	4	3	3	NUM
admet-394	17	5	]	]	PUNCT
admet-394	17	6	.	.	PUNCT
admet-394	18	1	these	these	DET
admet-394	18	2	genotoxic	genotoxic	ADJ
admet-394	18	3	agents	agent	NOUN
admet-394	18	4	are	be	AUX
admet-394	18	5	administered	administer	VERB
admet-394	18	6	to	to	ADP
admet-394	18	7	cancer	cancer	NOUN
admet-394	18	8	patients	patient	NOUN
admet-394	18	9	in	in	ADP
admet-394	18	10	combination	combination	NOUN
admet-394	18	11	,	,	PUNCT
admet-394	18	12	and	and	CCONJ
admet-394	18	13	in	in	ADP
admet-394	18	14	some	some	DET
admet-394	18	15	cases	case	NOUN
admet-394	18	16	with	with	ADP
admet-394	18	17	small	small	ADJ
admet-394	18	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-394	18	19	mailto:dindial.ramotar@umontreal.ca	mailto:dindial.ramotar@umontreal.ca	PROPN
admet-394	18	20	admet	admet	PROPN
admet-394	18	21	&	&	CCONJ
admet-394	18	22	dmpk	dmpk	PROPN
admet-394	18	23	5(3	5(3	NUM
admet-394	18	24	)	)	PUNCT
admet-394	18	25	(	(	PUNCT
admet-394	18	26	2017	2017	NUM
admet-394	18	27	)	)	PUNCT
admet-394	18	28	146	146	NUM
admet-394	18	29	-	-	SYM
admet-394	18	30	158	158	NUM
admet-394	18	31	oct-1	oct-1	NUM
admet-394	18	32	and	and	CCONJ
admet-394	18	33	oct-2	oct-2	NUM
admet-394	18	34	in	in	ADP
admet-394	18	35	caenorhabditis	caenorhabditis	PROPN
admet-394	18	36	elegans	elegan	NOUN
admet-394	18	37	doi	doi	NOUN
admet-394	18	38	:	:	PUNCT
admet-394	18	39	10.5599	10.5599	NUM
admet-394	18	40	/	/	SYM
admet-394	18	41	admet.5.3.394	admet.5.3.394	NOUN
admet-394	18	42	147	147	NUM
admet-394	18	43	molecule	molecule	NOUN
admet-394	18	44	inhibitors	inhibitor	NOUN
admet-394	18	45	to	to	PART
admet-394	18	46	block	block	VERB
admet-394	18	47	dna	dna	PROPN
admet-394	18	48	repair	repair	VERB
admet-394	18	49	pathways	pathway	NOUN
admet-394	18	50	with	with	ADP
admet-394	18	51	the	the	DET
admet-394	18	52	aim	aim	NOUN
admet-394	18	53	of	of	ADP
admet-394	18	54	sensitizing	sensitize	VERB
admet-394	18	55	cancer	cancer	NOUN
admet-394	18	56	cells	cell	NOUN
admet-394	18	57	towards	towards	ADP
admet-394	18	58	the	the	DET
admet-394	18	59	chemotherapeutic	chemotherapeutic	ADJ
admet-394	18	60	regimens	regimen	NOUN
admet-394	18	61	[	[	X
admet-394	18	62	4	4	NUM
admet-394	18	63	-	-	SYM
admet-394	18	64	8	8	NUM
admet-394	18	65	]	]	PUNCT
admet-394	18	66	.	.	PUNCT
admet-394	19	1	although	although	SCONJ
admet-394	19	2	these	these	DET
admet-394	19	3	molecules	molecule	NOUN
admet-394	19	4	are	be	AUX
admet-394	19	5	hydrophilic	hydrophilic	ADJ
admet-394	19	6	in	in	ADP
admet-394	19	7	nature	nature	NOUN
admet-394	19	8	,	,	PUNCT
admet-394	19	9	it	it	PRON
admet-394	19	10	was	be	AUX
admet-394	19	11	commonly	commonly	ADV
admet-394	19	12	accepted	accept	VERB
admet-394	19	13	that	that	SCONJ
admet-394	19	14	they	they	PRON
admet-394	19	15	diffuse	diffuse	VERB
admet-394	19	16	into	into	ADP
admet-394	19	17	cells	cell	NOUN
admet-394	19	18	.	.	PUNCT
admet-394	20	1	this	this	DET
admet-394	20	2	notion	notion	NOUN
admet-394	20	3	has	have	AUX
admet-394	20	4	been	be	AUX
admet-394	20	5	challenged	challenge	VERB
admet-394	20	6	as	as	SCONJ
admet-394	20	7	most	most	ADJ
admet-394	20	8	chemotherapeutics	chemotherapeutic	NOUN
admet-394	20	9	are	be	AUX
admet-394	20	10	charged	charge	VERB
admet-394	20	11	molecules	molecule	NOUN
admet-394	20	12	and	and	CCONJ
admet-394	20	13	structurally	structurally	ADV
admet-394	20	14	unrelated	unrelated	ADJ
admet-394	20	15	,	,	PUNCT
admet-394	20	16	and	and	CCONJ
admet-394	20	17	thus	thus	ADV
admet-394	20	18	can	can	AUX
admet-394	20	19	not	not	PART
admet-394	20	20	easily	easily	ADV
admet-394	20	21	cross	cross	VERB
admet-394	20	22	the	the	DET
admet-394	20	23	plasma	plasma	NOUN
admet-394	20	24	membrane	membrane	NOUN
admet-394	20	25	barrier	barrier	NOUN
admet-394	20	26	.	.	PUNCT
admet-394	21	1	moreover	moreover	ADV
admet-394	21	2	,	,	PUNCT
admet-394	21	3	a	a	DET
admet-394	21	4	single	single	ADJ
admet-394	21	5	chemotherapeutic	chemotherapeutic	ADJ
admet-394	21	6	agent	agent	NOUN
admet-394	21	7	does	do	AUX
admet-394	21	8	not	not	PART
admet-394	21	9	show	show	VERB
admet-394	21	10	the	the	DET
admet-394	21	11	same	same	ADJ
admet-394	21	12	genotoxicity	genotoxicity	NOUN
admet-394	21	13	when	when	SCONJ
admet-394	21	14	given	give	VERB
admet-394	21	15	to	to	ADP
admet-394	21	16	different	different	ADJ
admet-394	21	17	cell	cell	NOUN
admet-394	21	18	types	type	NOUN
admet-394	21	19	,	,	PUNCT
admet-394	21	20	as	as	SCONJ
admet-394	21	21	would	would	AUX
admet-394	21	22	be	be	AUX
admet-394	21	23	expected	expect	VERB
admet-394	21	24	in	in	ADP
admet-394	21	25	the	the	DET
admet-394	21	26	case	case	NOUN
admet-394	21	27	of	of	ADP
admet-394	21	28	simple	simple	ADJ
admet-394	21	29	drug	drug	NOUN
admet-394	21	30	diffusion	diffusion	NOUN
admet-394	21	31	.	.	PUNCT
admet-394	22	1	in	in	ADP
admet-394	22	2	fact	fact	NOUN
admet-394	22	3	,	,	PUNCT
admet-394	22	4	there	there	PRON
admet-394	22	5	is	be	VERB
admet-394	22	6	now	now	ADV
admet-394	22	7	growing	grow	VERB
admet-394	22	8	evidence	evidence	NOUN
admet-394	22	9	that	that	SCONJ
admet-394	22	10	these	these	DET
admet-394	22	11	charged	charge	VERB
admet-394	22	12	anticancer	anticancer	NOUN
admet-394	22	13	drugs	drug	NOUN
admet-394	22	14	depend	depend	VERB
admet-394	22	15	on	on	ADP
admet-394	22	16	facilitated	facilitated	ADJ
admet-394	22	17	transport	transport	NOUN
admet-394	22	18	mechanisms	mechanism	NOUN
admet-394	22	19	to	to	PART
admet-394	22	20	enter	enter	VERB
admet-394	22	21	cells	cell	NOUN
admet-394	22	22	in	in	ADP
admet-394	22	23	order	order	NOUN
admet-394	22	24	to	to	PART
admet-394	22	25	effectively	effectively	ADV
admet-394	22	26	reach	reach	VERB
admet-394	22	27	the	the	DET
admet-394	22	28	target	target	NOUN
admet-394	22	29	sites	site	NOUN
admet-394	22	30	.	.	PUNCT
admet-394	23	1	in	in	ADP
admet-394	23	2	human	human	ADJ
admet-394	23	3	cells	cell	NOUN
admet-394	23	4	,	,	PUNCT
admet-394	23	5	there	there	PRON
admet-394	23	6	are	be	VERB
admet-394	23	7	over	over	ADP
admet-394	23	8	450	450	NUM
admet-394	23	9	solute	solute	ADJ
admet-394	23	10	carrier	carrier	NOUN
admet-394	23	11	transporters	transporter	NOUN
admet-394	23	12	,	,	PUNCT
admet-394	23	13	which	which	PRON
admet-394	23	14	are	be	AUX
admet-394	23	15	believed	believe	VERB
admet-394	23	16	to	to	PART
admet-394	23	17	facilitate	facilitate	VERB
admet-394	23	18	the	the	DET
admet-394	23	19	uptake	uptake	NOUN
admet-394	23	20	of	of	ADP
admet-394	23	21	nutrients	nutrient	NOUN
admet-394	23	22	and	and	CCONJ
admet-394	23	23	ions	ion	NOUN
admet-394	23	24	.	.	PUNCT
admet-394	24	1	however	however	ADV
admet-394	24	2	,	,	PUNCT
admet-394	24	3	these	these	DET
admet-394	24	4	transporters	transporter	NOUN
admet-394	24	5	also	also	ADV
admet-394	24	6	perform	perform	VERB
admet-394	24	7	functions	function	NOUN
admet-394	24	8	that	that	PRON
admet-394	24	9	are	be	AUX
admet-394	24	10	distinct	distinct	ADJ
admet-394	24	11	as	as	SCONJ
admet-394	24	12	defects	defect	NOUN
admet-394	24	13	in	in	ADP
admet-394	24	14	30	30	NUM
admet-394	24	15	%	%	NOUN
admet-394	24	16	of	of	ADP
admet-394	24	17	the	the	DET
admet-394	24	18	transporters	transporter	NOUN
admet-394	24	19	are	be	AUX
admet-394	24	20	linked	link	VERB
admet-394	24	21	to	to	ADP
admet-394	24	22	diseases	disease	NOUN
admet-394	24	23	that	that	PRON
admet-394	24	24	may	may	AUX
admet-394	24	25	be	be	AUX
admet-394	24	26	related	relate	VERB
admet-394	24	27	to	to	ADP
admet-394	24	28	imbalances	imbalance	NOUN
admet-394	24	29	in	in	ADP
admet-394	24	30	the	the	DET
admet-394	24	31	uptake	uptake	NOUN
admet-394	24	32	of	of	ADP
admet-394	24	33	nutrients	nutrient	NOUN
admet-394	24	34	and	and	CCONJ
admet-394	24	35	ions	ion	NOUN
admet-394	24	36	at	at	ADP
admet-394	24	37	specific	specific	ADJ
admet-394	24	38	locations	location	NOUN
admet-394	24	39	.	.	PUNCT
admet-394	25	1	for	for	ADP
admet-394	25	2	example	example	NOUN
admet-394	25	3	,	,	PUNCT
admet-394	25	4	mutations	mutation	NOUN
admet-394	25	5	in	in	ADP
admet-394	25	6	slc22a4	slc22a4	NOUN
admet-394	25	7	lead	lead	VERB
admet-394	25	8	to	to	ADP
admet-394	25	9	crohn	crohn	PROPN
admet-394	25	10	disease	disease	PROPN
admet-394	25	11	,	,	PUNCT
admet-394	25	12	which	which	PRON
admet-394	25	13	affects	affect	VERB
admet-394	25	14	the	the	DET
admet-394	25	15	gastrointestinal	gastrointestinal	ADJ
admet-394	25	16	tract	tract	NOUN
admet-394	25	17	and	and	CCONJ
admet-394	25	18	mutations	mutation	NOUN
admet-394	25	19	in	in	ADP
admet-394	25	20	slc12a3	slc12a3	NOUN
admet-394	25	21	lead	lead	NOUN
admet-394	25	22	to	to	ADP
admet-394	25	23	gitelman	gitelman	NOUN
admet-394	25	24	’s	’s	PART
admet-394	25	25	syndrome	syndrome	NOUN
admet-394	25	26	characterized	characterize	VERB
admet-394	25	27	by	by	ADP
admet-394	25	28	low	low	ADJ
admet-394	25	29	blood	blood	NOUN
admet-394	25	30	pressure	pressure	NOUN
admet-394	25	31	[	[	X
admet-394	25	32	9	9	NUM
admet-394	25	33	,	,	PUNCT
admet-394	25	34	10	10	NUM
admet-394	25	35	]	]	PUNCT
admet-394	25	36	.	.	PUNCT
admet-394	26	1	besides	besides	SCONJ
admet-394	26	2	the	the	DET
admet-394	26	3	uptake	uptake	NOUN
admet-394	26	4	of	of	ADP
admet-394	26	5	nutrients	nutrient	NOUN
admet-394	26	6	and	and	CCONJ
admet-394	26	7	ions	ion	NOUN
admet-394	26	8	,	,	PUNCT
admet-394	26	9	some	some	PRON
admet-394	26	10	of	of	ADP
admet-394	26	11	these	these	DET
admet-394	26	12	transporters	transporter	NOUN
admet-394	26	13	are	be	AUX
admet-394	26	14	actively	actively	ADV
admet-394	26	15	involved	involve	VERB
admet-394	26	16	in	in	ADP
admet-394	26	17	the	the	DET
admet-394	26	18	influx	influx	NOUN
admet-394	26	19	of	of	ADP
admet-394	26	20	drugs	drug	NOUN
admet-394	26	21	for	for	ADP
admet-394	26	22	treating	treat	VERB
admet-394	26	23	various	various	ADJ
admet-394	26	24	illnesses	illness	NOUN
admet-394	26	25	.	.	PUNCT
admet-394	27	1	at	at	ADV
admet-394	27	2	least	least	ADV
admet-394	27	3	12	12	NUM
admet-394	27	4	of	of	ADP
admet-394	27	5	the	the	DET
admet-394	27	6	transporters	transporter	NOUN
admet-394	27	7	are	be	AUX
admet-394	27	8	specifically	specifically	ADV
admet-394	27	9	involved	involve	VERB
admet-394	27	10	in	in	ADP
admet-394	27	11	the	the	DET
admet-394	27	12	transport	transport	NOUN
admet-394	27	13	of	of	ADP
admet-394	27	14	drugs	drug	NOUN
admet-394	27	15	approved	approve	VERB
admet-394	27	16	by	by	ADP
admet-394	27	17	the	the	DET
admet-394	27	18	food	food	NOUN
admet-394	27	19	and	and	CCONJ
admet-394	27	20	drug	drug	PROPN
admet-394	27	21	administration	administration	NOUN
admet-394	27	22	(	(	PUNCT
admet-394	27	23	fda	fda	PROPN
admet-394	27	24	)	)	PUNCT
admet-394	27	25	,	,	PUNCT
admet-394	27	26	e.g	e.g	PROPN
admet-394	27	27	,	,	PUNCT
admet-394	27	28	slc6a3	slc6a3	NOUN
admet-394	27	29	transports	transport	VERB
admet-394	27	30	methylphenidate	methylphenidate	NOUN
admet-394	27	31	used	use	VERB
admet-394	27	32	for	for	ADP
admet-394	27	33	treating	treat	VERB
admet-394	27	34	psychiatric	psychiatric	ADJ
admet-394	27	35	disorders	disorder	NOUN
admet-394	27	36	[	[	X
admet-394	27	37	11	11	NUM
admet-394	27	38	]	]	PUNCT
admet-394	27	39	.	.	PUNCT
admet-394	28	1	in	in	ADP
admet-394	28	2	addition	addition	NOUN
admet-394	28	3	,	,	PUNCT
admet-394	28	4	a	a	DET
admet-394	28	5	few	few	ADJ
admet-394	28	6	of	of	ADP
admet-394	28	7	the	the	DET
admet-394	28	8	solute	solute	NOUN
admet-394	28	9	carriers	carrier	NOUN
admet-394	28	10	have	have	AUX
admet-394	28	11	been	be	AUX
admet-394	28	12	shown	show	VERB
admet-394	28	13	to	to	PART
admet-394	28	14	mediate	mediate	VERB
admet-394	28	15	uptake	uptake	NOUN
admet-394	28	16	of	of	ADP
admet-394	28	17	anticancer	anticancer	NOUN
admet-394	28	18	drugs	drug	NOUN
admet-394	28	19	.	.	PUNCT
admet-394	29	1	for	for	ADP
admet-394	29	2	example	example	NOUN
admet-394	29	3	,	,	PUNCT
admet-394	29	4	the	the	DET
admet-394	29	5	slc35f2	slc35f2	NOUN
admet-394	29	6	transporter	transporter	NOUN
admet-394	29	7	is	be	AUX
admet-394	29	8	completely	completely	ADV
admet-394	29	9	responsible	responsible	ADJ
admet-394	29	10	for	for	ADP
admet-394	29	11	the	the	DET
admet-394	29	12	uptake	uptake	NOUN
admet-394	29	13	into	into	ADP
admet-394	29	14	human	human	ADJ
admet-394	29	15	tumour	tumour	NOUN
admet-394	29	16	cells	cell	NOUN
admet-394	29	17	of	of	ADP
admet-394	29	18	the	the	DET
admet-394	29	19	anticancer	anticancer	NOUN
admet-394	29	20	drug	drug	PROPN
admet-394	29	21	ym155	ym155	PROPN
admet-394	29	22	,	,	PUNCT
admet-394	29	23	which	which	PRON
admet-394	29	24	is	be	AUX
admet-394	29	25	currently	currently	ADV
admet-394	29	26	in	in	ADP
admet-394	29	27	clinical	clinical	ADJ
admet-394	29	28	evaluation	evaluation	NOUN
admet-394	29	29	[	[	X
admet-394	29	30	12	12	NUM
admet-394	29	31	]	]	PUNCT
admet-394	29	32	.	.	PUNCT
admet-394	30	1	another	another	DET
admet-394	30	2	recent	recent	ADJ
admet-394	30	3	study	study	NOUN
admet-394	30	4	established	establish	VERB
admet-394	30	5	that	that	SCONJ
admet-394	30	6	the	the	DET
admet-394	30	7	organic	organic	ADJ
admet-394	30	8	cation	cation	NOUN
admet-394	30	9	transporter	transporter	NOUN
admet-394	30	10	slc22a2	slc22a2	NOUN
admet-394	30	11	(	(	PUNCT
admet-394	30	12	oct2	oct2	PROPN
admet-394	30	13	)	)	PUNCT
admet-394	30	14	is	be	AUX
admet-394	30	15	required	require	VERB
admet-394	30	16	for	for	ADP
admet-394	30	17	oxaliplatin	oxaliplatin	NOUN
admet-394	30	18	uptake	uptake	NOUN
admet-394	30	19	into	into	ADP
admet-394	30	20	renal	renal	ADJ
admet-394	30	21	cells	cell	NOUN
admet-394	30	22	and	and	CCONJ
admet-394	30	23	that	that	SCONJ
admet-394	30	24	downregulation	downregulation	NOUN
admet-394	30	25	of	of	ADP
admet-394	30	26	oct2	oct2	NOUN
admet-394	30	27	is	be	AUX
admet-394	30	28	a	a	DET
admet-394	30	29	cause	cause	NOUN
admet-394	30	30	for	for	ADP
admet-394	30	31	oxaliplatin	oxaliplatin	ADJ
admet-394	30	32	resistance	resistance	NOUN
admet-394	30	33	in	in	ADP
admet-394	30	34	renal	renal	ADJ
admet-394	30	35	cell	cell	NOUN
admet-394	30	36	carcinoma	carcinoma	NOUN
admet-394	31	1	[	[	X
admet-394	31	2	13	13	NUM
admet-394	31	3	]	]	PUNCT
admet-394	31	4	.	.	PUNCT
admet-394	32	1	however	however	ADV
admet-394	32	2	,	,	PUNCT
admet-394	32	3	these	these	DET
admet-394	32	4	resistant	resistant	ADJ
admet-394	32	5	renal	renal	ADJ
admet-394	32	6	cell	cell	NOUN
admet-394	32	7	carcinoma	carcinoma	NOUN
admet-394	32	8	can	can	AUX
admet-394	32	9	be	be	AUX
admet-394	32	10	sensitized	sensitize	VERB
admet-394	32	11	to	to	ADP
admet-394	32	12	oxaliplatin	oxaliplatin	NOUN
admet-394	32	13	upon	upon	SCONJ
admet-394	32	14	restoring	restore	VERB
admet-394	32	15	oct2	oct2	NOUN
admet-394	32	16	expression	expression	NOUN
admet-394	32	17	[	[	X
admet-394	32	18	13	13	NUM
admet-394	32	19	]	]	PUNCT
admet-394	32	20	.	.	PUNCT
admet-394	33	1	in	in	ADP
admet-394	33	2	a	a	DET
admet-394	33	3	final	final	ADJ
admet-394	33	4	example	example	NOUN
admet-394	33	5	,	,	PUNCT
admet-394	33	6	the	the	DET
admet-394	33	7	functional	functional	ADJ
admet-394	33	8	level	level	NOUN
admet-394	33	9	of	of	ADP
admet-394	33	10	another	another	DET
admet-394	33	11	member	member	NOUN
admet-394	33	12	of	of	ADP
admet-394	33	13	the	the	DET
admet-394	33	14	organic	organic	ADJ
admet-394	33	15	cation	cation	NOUN
admet-394	33	16	transporter	transporter	NOUN
admet-394	33	17	family	family	NOUN
admet-394	33	18	,	,	PUNCT
admet-394	33	19	slc22a1	slc22a1	PROPN
admet-394	33	20	(	(	PUNCT
admet-394	33	21	oct1	oct1	PROPN
admet-394	33	22	)	)	PUNCT
admet-394	33	23	,	,	PUNCT
admet-394	33	24	was	be	AUX
admet-394	33	25	shown	show	VERB
admet-394	33	26	to	to	PART
admet-394	33	27	be	be	AUX
admet-394	33	28	a	a	DET
admet-394	33	29	critical	critical	ADJ
admet-394	33	30	marker	marker	NOUN
admet-394	33	31	for	for	ADP
admet-394	33	32	the	the	DET
admet-394	33	33	responses	response	NOUN
admet-394	33	34	of	of	ADP
admet-394	33	35	chronic	chronic	ADJ
admet-394	33	36	-	-	PUNCT
admet-394	33	37	phase	phase	NOUN
admet-394	33	38	chronic	chronic	ADJ
admet-394	33	39	myeloid	myeloid	NOUN
admet-394	33	40	leukemia	leukemia	NOUN
admet-394	33	41	towards	towards	ADP
admet-394	33	42	the	the	DET
admet-394	33	43	tyrosine	tyrosine	NOUN
admet-394	33	44	kinase	kinase	PROPN
admet-394	33	45	inhibitor	inhibitor	PROPN
admet-394	33	46	imatinib	imatinib	NOUN
admet-394	33	47	[	[	X
admet-394	33	48	14	14	NUM
admet-394	33	49	]	]	PUNCT
admet-394	33	50	.	.	PUNCT
admet-394	34	1	patients	patient	NOUN
admet-394	34	2	with	with	ADP
admet-394	34	3	low	low	ADJ
admet-394	34	4	activity	activity	NOUN
admet-394	34	5	levels	level	NOUN
admet-394	34	6	of	of	ADP
admet-394	34	7	oct1	oct1	NOUN
admet-394	34	8	respond	respond	VERB
admet-394	34	9	poorly	poorly	ADV
admet-394	34	10	to	to	ADP
admet-394	34	11	imatinib	imatinib	NOUN
admet-394	34	12	and	and	CCONJ
admet-394	34	13	exhibit	exhibit	VERB
admet-394	34	14	lower	low	ADJ
admet-394	34	15	overall	overall	ADJ
admet-394	34	16	survival	survival	NOUN
admet-394	34	17	as	as	ADP
admet-394	34	18	compared	compare	VERB
admet-394	34	19	to	to	ADP
admet-394	34	20	those	those	PRON
admet-394	34	21	with	with	ADP
admet-394	34	22	high	high	ADJ
admet-394	34	23	levels	level	NOUN
admet-394	34	24	of	of	ADP
admet-394	34	25	oct1	oct1	NOUN
admet-394	34	26	[	[	X
admet-394	34	27	14	14	NUM
admet-394	34	28	]	]	PUNCT
admet-394	34	29	.	.	PUNCT
admet-394	35	1	this	this	DET
admet-394	35	2	same	same	ADJ
admet-394	35	3	transporter	transporter	NOUN
admet-394	35	4	was	be	AUX
admet-394	35	5	also	also	ADV
admet-394	35	6	shown	show	VERB
admet-394	35	7	to	to	PART
admet-394	35	8	transport	transport	VERB
admet-394	35	9	the	the	DET
admet-394	35	10	diabetes	diabetes	NOUN
admet-394	35	11	drug	drug	NOUN
admet-394	35	12	metformin	metformin	NOUN
admet-394	35	13	,	,	PUNCT
admet-394	35	14	which	which	PRON
admet-394	35	15	decreases	decrease	VERB
admet-394	35	16	production	production	NOUN
admet-394	35	17	of	of	ADP
admet-394	35	18	hepatic	hepatic	ADJ
admet-394	35	19	glucose	glucose	NOUN
admet-394	35	20	,	,	PUNCT
admet-394	35	21	thus	thus	ADV
admet-394	35	22	underscoring	underscore	VERB
admet-394	35	23	the	the	DET
admet-394	35	24	possibility	possibility	NOUN
admet-394	35	25	that	that	SCONJ
admet-394	35	26	many	many	ADJ
admet-394	35	27	of	of	ADP
admet-394	35	28	the	the	DET
admet-394	35	29	transporters	transporter	NOUN
admet-394	35	30	may	may	AUX
admet-394	35	31	likely	likely	ADV
admet-394	35	32	recognize	recognize	VERB
admet-394	35	33	multiple	multiple	ADJ
admet-394	35	34	substrates	substrate	NOUN
admet-394	35	35	[	[	X
admet-394	35	36	15	15	NUM
admet-394	35	37	]	]	PUNCT
admet-394	35	38	.	.	PUNCT
admet-394	36	1	these	these	DET
admet-394	36	2	foregoing	forego	VERB
admet-394	36	3	studies	study	NOUN
admet-394	36	4	raise	raise	VERB
admet-394	36	5	the	the	DET
admet-394	36	6	possibility	possibility	NOUN
admet-394	36	7	that	that	SCONJ
admet-394	36	8	although	although	SCONJ
admet-394	36	9	the	the	DET
admet-394	36	10	transporters	transporter	NOUN
admet-394	36	11	may	may	AUX
admet-394	36	12	have	have	AUX
admet-394	36	13	evolved	evolve	VERB
admet-394	36	14	to	to	PART
admet-394	36	15	mediate	mediate	VERB
admet-394	36	16	uptake	uptake	NOUN
admet-394	36	17	of	of	ADP
admet-394	36	18	common	common	ADJ
admet-394	36	19	nutrients	nutrient	NOUN
admet-394	36	20	and	and	CCONJ
admet-394	36	21	ions	ion	NOUN
admet-394	36	22	,	,	PUNCT
admet-394	36	23	they	they	PRON
admet-394	36	24	have	have	AUX
admet-394	36	25	the	the	DET
admet-394	36	26	ability	ability	NOUN
admet-394	36	27	to	to	PART
admet-394	36	28	recognize	recognize	VERB
admet-394	36	29	distinct	distinct	ADJ
admet-394	36	30	ligands	ligand	NOUN
admet-394	36	31	.	.	PUNCT
admet-394	37	1	while	while	SCONJ
admet-394	37	2	it	it	PRON
admet-394	37	3	is	be	AUX
admet-394	37	4	difficult	difficult	ADJ
admet-394	37	5	to	to	PART
admet-394	37	6	determine	determine	VERB
admet-394	37	7	the	the	DET
admet-394	37	8	ligands	ligand	NOUN
admet-394	37	9	for	for	ADP
admet-394	37	10	each	each	DET
admet-394	37	11	transporter	transporter	NOUN
admet-394	37	12	,	,	PUNCT
admet-394	37	13	it	it	PRON
admet-394	37	14	is	be	AUX
admet-394	37	15	anticipated	anticipate	VERB
admet-394	37	16	that	that	SCONJ
admet-394	37	17	with	with	ADP
admet-394	37	18	a	a	DET
admet-394	37	19	given	give	VERB
admet-394	37	20	substrate	substrate	NOUN
admet-394	37	21	the	the	DET
admet-394	37	22	transporter	transporter	NOUN
admet-394	37	23	can	can	AUX
admet-394	37	24	be	be	AUX
admet-394	37	25	identified	identify	VERB
admet-394	37	26	through	through	ADP
admet-394	37	27	biochemical	biochemical	ADJ
admet-394	37	28	and	and	CCONJ
admet-394	37	29	genetic	genetic	ADJ
admet-394	37	30	analyses	analysis	NOUN
admet-394	37	31	.	.	PUNCT
admet-394	38	1	since	since	SCONJ
admet-394	38	2	anthracyclines	anthracycline	NOUN
admet-394	38	3	are	be	AUX
admet-394	38	4	widely	widely	ADV
admet-394	38	5	used	use	VERB
admet-394	38	6	chemotherapeutic	chemotherapeutic	ADJ
admet-394	38	7	agents	agent	NOUN
admet-394	38	8	and	and	CCONJ
admet-394	38	9	initially	initially	ADV
admet-394	38	10	believed	believe	VERB
admet-394	38	11	to	to	PART
admet-394	38	12	diffuse	diffuse	VERB
admet-394	38	13	into	into	ADP
admet-394	38	14	cells	cell	NOUN
admet-394	38	15	,	,	PUNCT
admet-394	38	16	there	there	PRON
admet-394	38	17	has	have	AUX
admet-394	38	18	been	be	AUX
admet-394	38	19	little	little	ADJ
admet-394	38	20	interest	interest	NOUN
admet-394	38	21	to	to	PART
admet-394	38	22	determine	determine	VERB
admet-394	38	23	whether	whether	SCONJ
admet-394	38	24	a	a	DET
admet-394	38	25	transporter	transporter	NOUN
admet-394	38	26	exists	exist	VERB
admet-394	38	27	for	for	ADP
admet-394	38	28	these	these	DET
admet-394	38	29	drugs	drug	NOUN
admet-394	38	30	.	.	PUNCT
admet-394	39	1	we	we	PRON
admet-394	39	2	challenged	challenge	VERB
admet-394	39	3	the	the	DET
admet-394	39	4	initial	initial	ADJ
admet-394	39	5	view	view	NOUN
admet-394	39	6	and	and	CCONJ
admet-394	39	7	used	use	VERB
admet-394	39	8	anthracyclines	anthracycline	NOUN
admet-394	39	9	as	as	ADP
admet-394	39	10	the	the	DET
admet-394	39	11	ligands	ligand	NOUN
admet-394	39	12	to	to	PART
admet-394	39	13	search	search	VERB
admet-394	39	14	for	for	ADP
admet-394	39	15	a	a	DET
admet-394	39	16	transporter	transporter	NOUN
admet-394	39	17	.	.	PUNCT
admet-394	40	1	below	below	ADP
admet-394	40	2	highlights	highlight	NOUN
admet-394	40	3	the	the	DET
admet-394	40	4	key	key	ADJ
admet-394	40	5	findings	finding	NOUN
admet-394	40	6	that	that	PRON
admet-394	40	7	establish	establish	VERB
admet-394	40	8	the	the	DET
admet-394	40	9	existence	existence	NOUN
admet-394	40	10	of	of	ADP
admet-394	40	11	a	a	DET
admet-394	40	12	human	human	ADJ
admet-394	40	13	transporter	transporter	NOUN
admet-394	40	14	oct1	oct1	NOUN
admet-394	40	15	,	,	PUNCT
admet-394	40	16	which	which	PRON
admet-394	40	17	mediates	mediate	VERB
admet-394	40	18	uptake	uptake	ADJ
admet-394	40	19	of	of	ADP
admet-394	40	20	anthracyclines	anthracycline	NOUN
admet-394	40	21	into	into	ADP
admet-394	40	22	cells	cell	NOUN
admet-394	40	23	and	and	CCONJ
admet-394	40	24	how	how	SCONJ
admet-394	40	25	this	this	DET
admet-394	40	26	discovery	discovery	NOUN
admet-394	40	27	was	be	AUX
admet-394	40	28	exploited	exploit	VERB
admet-394	40	29	to	to	PART
admet-394	40	30	uncover	uncover	VERB
admet-394	40	31	similar	similar	ADJ
admet-394	40	32	transporters	transporter	NOUN
admet-394	40	33	in	in	ADP
admet-394	40	34	the	the	DET
admet-394	40	35	model	model	NOUN
admet-394	40	36	organism	organism	PROPN
admet-394	40	37	caenorhabditis	caenorhabditis	PROPN
admet-394	40	38	elegans	elegan	NOUN
admet-394	40	39	(	(	PUNCT
admet-394	40	40	c.	c.	PROPN
admet-394	40	41	elegans	elegans	PROPN
admet-394	40	42	)	)	PUNCT
admet-394	40	43	.	.	PUNCT
admet-394	41	1	dindial	dindial	ADJ
admet-394	41	2	ramotar	ramotar	PROPN
admet-394	41	3	admet	admet	PROPN
admet-394	41	4	&	&	CCONJ
admet-394	41	5	dmpk	dmpk	PROPN
admet-394	41	6	5(3	5(3	NUM
admet-394	41	7	)	)	PUNCT
admet-394	41	8	(	(	PUNCT
admet-394	41	9	2017	2017	NUM
admet-394	41	10	)	)	PUNCT
admet-394	41	11	146	146	NUM
admet-394	41	12	-	-	SYM
admet-394	41	13	158	158	NUM
admet-394	41	14	148	148	NUM
admet-394	41	15	human	human	ADJ
admet-394	41	16	oct1	oct1	NOUN
admet-394	41	17	transports	transport	NOUN
admet-394	41	18	anthracyclines	anthracycline	NOUN
admet-394	41	19	anthracyclines	anthracycline	NOUN
admet-394	41	20	such	such	ADJ
admet-394	41	21	as	as	ADP
admet-394	41	22	doxorubicin	doxorubicin	PROPN
admet-394	41	23	and	and	CCONJ
admet-394	41	24	daunorubicin	daunorubicin	PROPN
admet-394	41	25	act	act	VERB
admet-394	41	26	by	by	ADP
admet-394	41	27	intercalating	intercalate	VERB
admet-394	41	28	with	with	ADP
admet-394	41	29	the	the	DET
admet-394	41	30	dna	dna	PROPN
admet-394	41	31	and	and	CCONJ
admet-394	41	32	blocking	block	VERB
admet-394	41	33	the	the	DET
admet-394	41	34	function	function	NOUN
admet-394	41	35	of	of	ADP
admet-394	41	36	dna	dna	PROPN
admet-394	41	37	topoisomerase	topoisomerase	NOUN
admet-394	41	38	leading	lead	VERB
admet-394	41	39	to	to	ADP
admet-394	41	40	the	the	DET
admet-394	41	41	accumulation	accumulation	NOUN
admet-394	41	42	of	of	ADP
admet-394	41	43	dna	dna	PROPN
admet-394	41	44	lesions	lesion	NOUN
admet-394	41	45	and	and	CCONJ
admet-394	41	46	subsequent	subsequent	ADJ
admet-394	41	47	cell	cell	NOUN
admet-394	41	48	death	death	NOUN
admet-394	42	1	[	[	X
admet-394	42	2	16	16	NUM
admet-394	42	3	]	]	PUNCT
admet-394	42	4	.	.	PUNCT
admet-394	43	1	monitoring	monitor	VERB
admet-394	43	2	anthracyclines	anthracycline	NOUN
admet-394	43	3	entry	entry	NOUN
admet-394	43	4	into	into	ADP
admet-394	43	5	cells	cell	NOUN
admet-394	43	6	was	be	AUX
admet-394	43	7	made	make	VERB
admet-394	43	8	possible	possible	ADJ
admet-394	43	9	as	as	SCONJ
admet-394	43	10	these	these	DET
admet-394	43	11	drugs	drug	NOUN
admet-394	43	12	autofluoresce	autofluoresce	VERB
admet-394	43	13	at	at	ADP
admet-394	43	14	640	640	NUM
admet-394	43	15	nm	nm	NOUN
admet-394	43	16	,	,	PUNCT
admet-394	43	17	which	which	PRON
admet-394	43	18	provides	provide	VERB
admet-394	43	19	an	an	DET
admet-394	43	20	important	important	ADJ
admet-394	43	21	physical	physical	ADJ
admet-394	43	22	property	property	NOUN
admet-394	43	23	for	for	ADP
admet-394	43	24	the	the	DET
admet-394	43	25	development	development	NOUN
admet-394	43	26	of	of	ADP
admet-394	43	27	in	in	ADP
admet-394	43	28	vitro	vitro	X
admet-394	43	29	assays	assay	NOUN
admet-394	43	30	to	to	PART
admet-394	43	31	quantitatively	quantitatively	ADV
admet-394	43	32	assess	assess	VERB
admet-394	43	33	the	the	DET
admet-394	43	34	intracellular	intracellular	ADJ
admet-394	43	35	uptake	uptake	ADJ
admet-394	43	36	levels	level	NOUN
admet-394	43	37	.	.	PUNCT
admet-394	44	1	these	these	PRON
admet-394	44	2	in	in	ADP
admet-394	44	3	vitro	vitro	X
admet-394	44	4	assays	assay	NOUN
admet-394	44	5	monitor	monitor	VERB
admet-394	44	6	drug	drug	NOUN
admet-394	44	7	uptake	uptake	ADJ
admet-394	44	8	into	into	ADP
admet-394	44	9	the	the	DET
admet-394	44	10	cells	cell	NOUN
admet-394	44	11	as	as	ADP
admet-394	44	12	a	a	DET
admet-394	44	13	function	function	NOUN
admet-394	44	14	of	of	ADP
admet-394	44	15	time	time	NOUN
admet-394	44	16	using	use	VERB
admet-394	44	17	quantitative	quantitative	ADJ
admet-394	44	18	approaches	approach	NOUN
admet-394	44	19	such	such	ADJ
admet-394	44	20	as	as	ADP
admet-394	44	21	fluorescence	fluorescence	ADJ
admet-394	44	22	-	-	PUNCT
admet-394	44	23	activated	activate	VERB
admet-394	44	24	cell	cell	NOUN
admet-394	44	25	sorting	sort	VERB
admet-394	44	26	(	(	PUNCT
admet-394	44	27	facs	fac	NOUN
admet-394	44	28	)	)	PUNCT
admet-394	44	29	analysis	analysis	NOUN
admet-394	44	30	and	and	CCONJ
admet-394	44	31	fluorometry	fluorometry	NOUN
admet-394	44	32	,	,	PUNCT
admet-394	44	33	as	as	ADV
admet-394	44	34	well	well	ADV
admet-394	44	35	as	as	ADP
admet-394	44	36	a	a	DET
admet-394	44	37	semi	semi	ADJ
admet-394	44	38	-	-	ADJ
admet-394	44	39	quantitative	quantitative	ADJ
admet-394	44	40	method	method	NOUN
admet-394	44	41	involving	involve	VERB
admet-394	44	42	epifluorescence	epifluorescence	NOUN
admet-394	44	43	microscopy	microscopy	NOUN
admet-394	44	44	[	[	X
admet-394	44	45	17	17	NUM
admet-394	44	46	,	,	PUNCT
admet-394	44	47	18	18	NUM
admet-394	44	48	]	]	PUNCT
admet-394	44	49	.	.	PUNCT
admet-394	45	1	using	use	VERB
admet-394	45	2	these	these	DET
admet-394	45	3	assays	assay	NOUN
admet-394	45	4	and	and	CCONJ
admet-394	45	5	a	a	DET
admet-394	45	6	panel	panel	NOUN
admet-394	45	7	of	of	ADP
admet-394	45	8	cancer	cancer	NOUN
admet-394	45	9	cell	cell	NOUN
admet-394	45	10	lines	line	NOUN
admet-394	45	11	such	such	ADJ
admet-394	45	12	as	as	ADP
admet-394	45	13	the	the	DET
admet-394	45	14	leukemia	leukemia	NOUN
admet-394	45	15	hl60	hl60	PROPN
admet-394	45	16	and	and	CCONJ
admet-394	45	17	the	the	DET
admet-394	45	18	ovarian	ovarian	ADJ
admet-394	45	19	tov222g2	tov222g2	PROPN
admet-394	45	20	cell	cell	NOUN
admet-394	45	21	lines	line	NOUN
admet-394	45	22	,	,	PUNCT
admet-394	45	23	it	it	PRON
admet-394	45	24	was	be	AUX
admet-394	45	25	shown	show	VERB
admet-394	45	26	that	that	SCONJ
admet-394	45	27	daunorubicin	daunorubicin	PROPN
admet-394	45	28	or	or	CCONJ
admet-394	45	29	doxorubicin	doxorubicin	PROPN
admet-394	45	30	at	at	ADP
admet-394	45	31	5	5	NUM
admet-394	45	32	µm	µm	NOUN
admet-394	45	33	enters	enter	VERB
admet-394	45	34	these	these	DET
admet-394	45	35	cells	cell	NOUN
admet-394	45	36	in	in	ADP
admet-394	45	37	a	a	DET
admet-394	45	38	timeand	timeand	NOUN
admet-394	45	39	a	a	DET
admet-394	45	40	concentration	concentration	NOUN
admet-394	45	41	-	-	PUNCT
admet-394	45	42	dependent	dependent	ADJ
admet-394	45	43	manner	manner	NOUN
admet-394	45	44	and	and	CCONJ
admet-394	45	45	reaching	reach	VERB
admet-394	45	46	saturation	saturation	NOUN
admet-394	45	47	within	within	ADP
admet-394	45	48	60	60	NUM
admet-394	45	49	min	min	NOUN
admet-394	46	1	[	[	X
admet-394	46	2	19	19	NUM
admet-394	46	3	]	]	PUNCT
admet-394	46	4	.	.	PUNCT
admet-394	47	1	these	these	DET
admet-394	47	2	observations	observation	NOUN
admet-394	47	3	establish	establish	VERB
admet-394	47	4	for	for	ADP
admet-394	47	5	the	the	DET
admet-394	47	6	first	first	ADJ
admet-394	47	7	time	time	NOUN
admet-394	47	8	that	that	SCONJ
admet-394	47	9	there	there	PRON
admet-394	47	10	is	be	VERB
admet-394	47	11	an	an	DET
admet-394	47	12	active	active	ADJ
admet-394	47	13	transport	transport	NOUN
admet-394	47	14	mechanism	mechanism	NOUN
admet-394	47	15	for	for	ADP
admet-394	47	16	anthracyclines	anthracycline	NOUN
admet-394	47	17	into	into	ADP
admet-394	47	18	cells	cell	NOUN
admet-394	47	19	,	,	PUNCT
admet-394	47	20	eliminating	eliminate	VERB
admet-394	47	21	the	the	DET
admet-394	47	22	possibility	possibility	NOUN
admet-394	47	23	that	that	SCONJ
admet-394	47	24	diffusion	diffusion	NOUN
admet-394	47	25	accounts	account	VERB
admet-394	47	26	for	for	ADP
admet-394	47	27	the	the	DET
admet-394	47	28	major	major	ADJ
admet-394	47	29	accumulation	accumulation	NOUN
admet-394	47	30	of	of	ADP
admet-394	47	31	the	the	DET
admet-394	47	32	drug	drug	NOUN
admet-394	47	33	into	into	ADP
admet-394	47	34	cells	cell	NOUN
admet-394	47	35	[	[	X
admet-394	47	36	19	19	NUM
admet-394	47	37	]	]	PUNCT
admet-394	47	38	.	.	PUNCT
admet-394	48	1	although	although	SCONJ
admet-394	48	2	earlier	early	ADJ
admet-394	48	3	studies	study	NOUN
admet-394	48	4	claimed	claim	VERB
admet-394	48	5	that	that	SCONJ
admet-394	48	6	the	the	DET
admet-394	48	7	active	active	ADJ
admet-394	48	8	transport	transport	NOUN
admet-394	48	9	mechanism	mechanism	NOUN
admet-394	48	10	for	for	ADP
admet-394	48	11	doxorubicin	doxorubicin	PROPN
admet-394	48	12	uptake	uptake	NOUN
admet-394	48	13	involved	involve	VERB
admet-394	48	14	the	the	DET
admet-394	48	15	human	human	ADJ
admet-394	48	16	slc22a16	slc22a16	NOUN
admet-394	48	17	(	(	PUNCT
admet-394	48	18	hct2	hct2	NOUN
admet-394	48	19	/	/	SYM
admet-394	48	20	oct6	oct6	PROPN
admet-394	48	21	)	)	PUNCT
admet-394	48	22	and	and	CCONJ
admet-394	48	23	slc22a4	slc22a4	PROPN
admet-394	48	24	(	(	PUNCT
admet-394	48	25	octn1	octn1	ADJ
admet-394	48	26	)	)	PUNCT
admet-394	48	27	transporters	transporter	NOUN
admet-394	48	28	,	,	PUNCT
admet-394	48	29	subsequent	subsequent	ADJ
admet-394	48	30	findings	finding	NOUN
admet-394	48	31	proved	prove	VERB
admet-394	48	32	that	that	SCONJ
admet-394	48	33	these	these	PRON
admet-394	48	34	were	be	AUX
admet-394	48	35	not	not	PART
admet-394	48	36	the	the	DET
admet-394	48	37	transporters	transporter	NOUN
admet-394	48	38	[	[	X
admet-394	48	39	18	18	NUM
admet-394	48	40	,	,	PUNCT
admet-394	48	41	20	20	NUM
admet-394	48	42	,	,	PUNCT
admet-394	48	43	21	21	NUM
admet-394	48	44	]	]	PUNCT
admet-394	48	45	.	.	PUNCT
admet-394	49	1	however	however	ADV
admet-394	49	2	,	,	PUNCT
admet-394	49	3	it	it	PRON
admet-394	49	4	was	be	AUX
admet-394	49	5	studies	study	NOUN
admet-394	49	6	from	from	ADP
admet-394	49	7	the	the	DET
admet-394	49	8	budding	bud	VERB
admet-394	49	9	yeast	yeast	NOUN
admet-394	49	10	saccharomyces	saccharomyce	NOUN
admet-394	49	11	cerevisiae	cerevisiae	NOUN
admet-394	49	12	that	that	PRON
admet-394	49	13	provided	provide	VERB
admet-394	49	14	clues	clue	NOUN
admet-394	49	15	to	to	ADP
admet-394	49	16	the	the	DET
admet-394	49	17	actual	actual	ADJ
admet-394	49	18	transporter	transporter	NOUN
admet-394	49	19	by	by	ADP
admet-394	49	20	directly	directly	ADV
admet-394	49	21	linking	link	VERB
admet-394	49	22	anthracycline	anthracycline	NOUN
admet-394	49	23	-	-	PUNCT
admet-394	49	24	mediated	mediate	VERB
admet-394	49	25	uptake	uptake	NOUN
admet-394	49	26	to	to	ADP
admet-394	49	27	the	the	DET
admet-394	49	28	family	family	NOUN
admet-394	49	29	of	of	ADP
admet-394	49	30	oct	oct	PROPN
admet-394	49	31	transporters	transporter	NOUN
admet-394	49	32	.	.	PUNCT
admet-394	50	1	in	in	ADP
admet-394	50	2	human	human	ADJ
admet-394	50	3	cells	cell	NOUN
admet-394	50	4	,	,	PUNCT
admet-394	50	5	there	there	PRON
admet-394	50	6	are	be	VERB
admet-394	50	7	three	three	NUM
admet-394	50	8	oct	oct	NOUN
admet-394	50	9	homologues	homologue	NOUN
admet-394	50	10	oct1	oct1	NOUN
admet-394	50	11	,	,	PUNCT
admet-394	50	12	oct2	oct2	NOUN
admet-394	50	13	and	and	CCONJ
admet-394	50	14	oct3	oct3	PROPN
admet-394	50	15	that	that	PRON
admet-394	50	16	are	be	AUX
admet-394	50	17	members	member	NOUN
admet-394	50	18	of	of	ADP
admet-394	50	19	one	one	NUM
admet-394	50	20	family	family	NOUN
admet-394	50	21	of	of	ADP
admet-394	50	22	organic	organic	ADJ
admet-394	50	23	cation	cation	NOUN
admet-394	50	24	transporters	transporter	NOUN
admet-394	50	25	all	all	PRON
admet-394	50	26	of	of	ADP
admet-394	50	27	which	which	PRON
admet-394	50	28	can	can	AUX
admet-394	50	29	transport	transport	VERB
admet-394	50	30	choline	choline	NOUN
admet-394	50	31	with	with	ADP
admet-394	50	32	varying	vary	VERB
admet-394	50	33	affinities	affinity	NOUN
admet-394	50	34	.	.	PUNCT
admet-394	51	1	we	we	PRON
admet-394	51	2	therefore	therefore	ADV
admet-394	51	3	conducted	conduct	VERB
admet-394	51	4	competition	competition	NOUN
admet-394	51	5	experiments	experiment	NOUN
admet-394	51	6	with	with	ADP
admet-394	51	7	the	the	DET
admet-394	51	8	human	human	ADJ
admet-394	51	9	cancer	cancer	NOUN
admet-394	51	10	cell	cell	NOUN
admet-394	51	11	lines	line	NOUN
admet-394	51	12	and	and	CCONJ
admet-394	51	13	documented	document	VERB
admet-394	51	14	that	that	PRON
admet-394	51	15	choline	choline	NOUN
admet-394	51	16	completely	completely	ADV
admet-394	51	17	blocked	block	VERB
admet-394	51	18	the	the	DET
admet-394	51	19	uptake	uptake	NOUN
admet-394	51	20	of	of	ADP
admet-394	51	21	daunorubicin	daunorubicin	NOUN
admet-394	51	22	into	into	ADP
admet-394	51	23	the	the	DET
admet-394	51	24	cells	cell	NOUN
admet-394	51	25	when	when	SCONJ
admet-394	51	26	added	add	VERB
admet-394	51	27	at	at	ADP
admet-394	51	28	nearly	nearly	ADV
admet-394	51	29	equimolar	equimolar	ADJ
admet-394	51	30	amounts	amount	NOUN
admet-394	51	31	[	[	X
admet-394	51	32	19	19	NUM
admet-394	51	33	]	]	PUNCT
admet-394	51	34	.	.	PUNCT
admet-394	52	1	since	since	SCONJ
admet-394	52	2	oct1	oct1	NOUN
admet-394	52	3	has	have	VERB
admet-394	52	4	a	a	DET
admet-394	52	5	higher	high	ADJ
admet-394	52	6	affinity	affinity	NOUN
admet-394	52	7	for	for	ADP
admet-394	52	8	choline	choline	NOUN
admet-394	52	9	than	than	ADP
admet-394	52	10	oct2	oct2	NOUN
admet-394	52	11	and	and	CCONJ
admet-394	52	12	oct3	oct3	PROPN
admet-394	52	13	and	and	CCONJ
admet-394	52	14	can	can	AUX
admet-394	52	15	mediate	mediate	VERB
admet-394	52	16	uptake	uptake	ADJ
admet-394	52	17	of	of	ADP
admet-394	52	18	several	several	ADJ
admet-394	52	19	different	different	ADJ
admet-394	52	20	ligands	ligand	NOUN
admet-394	52	21	into	into	ADP
admet-394	52	22	cells	cell	NOUN
admet-394	52	23	,	,	PUNCT
admet-394	52	24	it	it	PRON
admet-394	52	25	is	be	AUX
admet-394	52	26	strongly	strongly	ADV
admet-394	52	27	suggested	suggest	VERB
admet-394	52	28	that	that	SCONJ
admet-394	52	29	it	it	PRON
admet-394	52	30	could	could	AUX
admet-394	52	31	be	be	AUX
admet-394	52	32	a	a	DET
admet-394	52	33	suitable	suitable	ADJ
admet-394	52	34	candidate	candidate	NOUN
admet-394	52	35	to	to	PART
admet-394	52	36	explore	explore	VERB
admet-394	52	37	for	for	ADP
admet-394	52	38	a	a	DET
admet-394	52	39	role	role	NOUN
admet-394	52	40	in	in	ADP
admet-394	52	41	anthracycline	anthracycline	NOUN
admet-394	52	42	uptake	uptake	ADJ
admet-394	52	43	.	.	PUNCT
admet-394	53	1	the	the	DET
admet-394	53	2	first	first	ADJ
admet-394	53	3	direct	direct	ADJ
admet-394	53	4	evidence	evidence	NOUN
admet-394	53	5	came	come	VERB
admet-394	53	6	from	from	ADP
admet-394	53	7	silencing	silence	VERB
admet-394	53	8	oct1	oct1	NOUN
admet-394	53	9	expression	expression	NOUN
admet-394	53	10	by	by	ADP
admet-394	53	11	shrna	shrna	NOUN
admet-394	53	12	in	in	ADP
admet-394	53	13	the	the	DET
admet-394	53	14	ovarian	ovarian	ADJ
admet-394	53	15	cancer	cancer	NOUN
admet-394	53	16	cells	cell	NOUN
admet-394	53	17	tov222g2	tov222g2	PROPN
admet-394	53	18	,	,	PUNCT
admet-394	53	19	which	which	PRON
admet-394	53	20	sharply	sharply	ADV
admet-394	53	21	reduced	reduce	VERB
admet-394	53	22	the	the	DET
admet-394	53	23	oct1	oct1	NOUN
admet-394	53	24	protein	protein	NOUN
admet-394	53	25	level	level	NOUN
admet-394	53	26	,	,	PUNCT
admet-394	53	27	as	as	SCONJ
admet-394	53	28	revealed	reveal	VERB
admet-394	53	29	by	by	ADP
admet-394	53	30	anti	anti	ADJ
admet-394	53	31	-	-	ADJ
admet-394	53	32	oct1	oct1	ADJ
admet-394	53	33	antibodies	antibodie	VERB
admet-394	53	34	[	[	X
admet-394	53	35	19	19	NUM
admet-394	53	36	]	]	PUNCT
admet-394	53	37	.	.	PUNCT
admet-394	54	1	these	these	DET
admet-394	54	2	oct1	oct1	NOUN
admet-394	54	3	downregulated	downregulate	VERB
admet-394	54	4	cells	cell	NOUN
admet-394	54	5	showed	show	VERB
admet-394	54	6	nearly	nearly	ADV
admet-394	54	7	85	85	NUM
admet-394	54	8	%	%	NOUN
admet-394	54	9	reduction	reduction	NOUN
admet-394	54	10	in	in	ADP
admet-394	54	11	daunorubicin	daunorubicin	NOUN
admet-394	54	12	uptake	uptake	ADJ
admet-394	54	13	when	when	SCONJ
admet-394	54	14	compared	compare	VERB
admet-394	54	15	to	to	ADP
admet-394	54	16	the	the	DET
admet-394	54	17	control	control	NOUN
admet-394	54	18	shrna	shrna	NOUN
admet-394	54	19	that	that	PRON
admet-394	54	20	showed	show	VERB
admet-394	54	21	no	no	DET
admet-394	54	22	effect	effect	NOUN
admet-394	54	23	[	[	X
admet-394	54	24	19	19	NUM
admet-394	54	25	]	]	PUNCT
admet-394	54	26	.	.	PUNCT
admet-394	55	1	as	as	ADP
admet-394	55	2	a	a	DET
admet-394	55	3	corollary	corollary	ADJ
admet-394	55	4	experiment	experiment	NOUN
admet-394	55	5	,	,	PUNCT
admet-394	55	6	overproduction	overproduction	NOUN
admet-394	55	7	of	of	ADP
admet-394	55	8	oct1	oct1	NOUN
admet-394	55	9	which	which	PRON
admet-394	55	10	is	be	AUX
admet-394	55	11	localized	localize	VERB
admet-394	55	12	to	to	ADP
admet-394	55	13	the	the	DET
admet-394	55	14	plasma	plasma	NOUN
admet-394	55	15	membrane	membrane	NOUN
admet-394	55	16	,	,	PUNCT
admet-394	55	17	stimulated	stimulate	VERB
admet-394	55	18	daunorubicin	daunorubicin	NOUN
admet-394	55	19	uptake	uptake	ADJ
admet-394	55	20	into	into	ADP
admet-394	55	21	the	the	DET
admet-394	55	22	cancer	cancer	NOUN
admet-394	55	23	cell	cell	NOUN
admet-394	55	24	lines	line	NOUN
admet-394	56	1	[	[	X
admet-394	56	2	19	19	NUM
admet-394	56	3	]	]	PUNCT
admet-394	56	4	.	.	PUNCT
admet-394	57	1	collectively	collectively	ADV
admet-394	57	2	,	,	PUNCT
admet-394	57	3	these	these	DET
admet-394	57	4	studies	study	NOUN
admet-394	57	5	provide	provide	VERB
admet-394	57	6	the	the	DET
admet-394	57	7	first	first	ADJ
admet-394	57	8	convincing	convincing	ADJ
admet-394	57	9	evidence	evidence	NOUN
admet-394	57	10	that	that	SCONJ
admet-394	57	11	oct1	oct1	NOUN
admet-394	57	12	functional	functional	ADJ
admet-394	57	13	level	level	NOUN
admet-394	57	14	might	might	AUX
admet-394	57	15	be	be	AUX
admet-394	57	16	pivotal	pivotal	ADJ
admet-394	57	17	in	in	ADP
admet-394	57	18	determining	determine	VERB
admet-394	57	19	the	the	DET
admet-394	57	20	effectiveness	effectiveness	NOUN
admet-394	57	21	of	of	ADP
admet-394	57	22	treatment	treatment	NOUN
admet-394	57	23	with	with	ADP
admet-394	57	24	anthracyclines	anthracycline	NOUN
admet-394	57	25	.	.	PUNCT
admet-394	58	1	since	since	SCONJ
admet-394	58	2	anthracyclines	anthracycline	NOUN
admet-394	58	3	are	be	AUX
admet-394	58	4	used	use	VERB
admet-394	58	5	for	for	ADP
admet-394	58	6	treating	treat	VERB
admet-394	58	7	leukemia	leukemia	NOUN
admet-394	58	8	as	as	ADV
admet-394	58	9	well	well	ADV
admet-394	58	10	as	as	ADP
admet-394	58	11	several	several	ADJ
admet-394	58	12	other	other	ADJ
admet-394	58	13	types	type	NOUN
admet-394	58	14	of	of	ADP
admet-394	58	15	cancers	cancer	NOUN
admet-394	58	16	such	such	ADJ
admet-394	58	17	as	as	ADP
admet-394	58	18	lymphomas	lymphoma	NOUN
admet-394	58	19	,	,	PUNCT
admet-394	58	20	breast	breast	NOUN
admet-394	58	21	,	,	PUNCT
admet-394	58	22	ovarian	ovarian	ADJ
admet-394	58	23	,	,	PUNCT
admet-394	58	24	and	and	CCONJ
admet-394	58	25	gastric	gastric	ADJ
admet-394	58	26	,	,	PUNCT
admet-394	58	27	it	it	PRON
admet-394	58	28	is	be	AUX
admet-394	58	29	anticipated	anticipate	VERB
admet-394	58	30	that	that	SCONJ
admet-394	58	31	patients	patient	NOUN
admet-394	58	32	who	who	PRON
admet-394	58	33	are	be	AUX
admet-394	58	34	refractory	refractory	NOUN
admet-394	58	35	to	to	PART
admet-394	58	36	anthracycline	anthracycline	VERB
admet-394	58	37	treatment	treatment	NOUN
admet-394	58	38	are	be	AUX
admet-394	58	39	likely	likely	ADJ
admet-394	58	40	to	to	PART
admet-394	58	41	be	be	AUX
admet-394	58	42	defective	defective	ADJ
admet-394	58	43	in	in	ADP
admet-394	58	44	the	the	DET
admet-394	58	45	uptake	uptake	ADJ
admet-394	58	46	transporter	transporter	NOUN
admet-394	58	47	[	[	X
admet-394	58	48	22	22	NUM
admet-394	58	49	-	-	SYM
admet-394	58	50	26	26	NUM
admet-394	58	51	]	]	PUNCT
admet-394	58	52	.	.	PUNCT
admet-394	59	1	conversely	conversely	ADV
admet-394	59	2	,	,	PUNCT
admet-394	59	3	patients	patient	NOUN
admet-394	59	4	with	with	ADP
admet-394	59	5	induced	induced	ADJ
admet-394	59	6	levels	level	NOUN
admet-394	59	7	or	or	CCONJ
admet-394	59	8	activated	activate	VERB
admet-394	59	9	oct1	oct1	NOUN
admet-394	59	10	could	could	AUX
admet-394	59	11	be	be	AUX
admet-394	59	12	hypersensitive	hypersensitive	ADJ
admet-394	59	13	to	to	ADP
admet-394	59	14	anthracyclines	anthracycline	NOUN
admet-394	59	15	.	.	PUNCT
admet-394	60	1	because	because	SCONJ
admet-394	60	2	the	the	DET
admet-394	60	3	human	human	ADJ
admet-394	60	4	oct1	oct1	NOUN
admet-394	60	5	transporter	transporter	NOUN
admet-394	60	6	displays	display	VERB
admet-394	60	7	broad	broad	ADJ
admet-394	60	8	substrate	substrate	NOUN
admet-394	60	9	specificity	specificity	NOUN
admet-394	60	10	,	,	PUNCT
admet-394	60	11	it	it	PRON
admet-394	60	12	is	be	AUX
admet-394	60	13	imperative	imperative	ADJ
admet-394	60	14	to	to	PART
admet-394	60	15	investigate	investigate	VERB
admet-394	60	16	whether	whether	SCONJ
admet-394	60	17	its	its	PRON
admet-394	60	18	function	function	NOUN
admet-394	60	19	in	in	ADP
admet-394	60	20	drug	drug	NOUN
admet-394	60	21	transport	transport	NOUN
admet-394	60	22	can	can	AUX
admet-394	60	23	be	be	AUX
admet-394	60	24	influenced	influence	VERB
admet-394	60	25	by	by	ADP
admet-394	60	26	the	the	DET
admet-394	60	27	presence	presence	NOUN
admet-394	60	28	of	of	ADP
admet-394	60	29	additional	additional	ADJ
admet-394	60	30	drugs	drug	NOUN
admet-394	60	31	,	,	PUNCT
admet-394	60	32	nutrients	nutrient	NOUN
admet-394	60	33	,	,	PUNCT
admet-394	60	34	and	and	CCONJ
admet-394	60	35	or	or	CCONJ
admet-394	60	36	the	the	DET
admet-394	60	37	status	status	NOUN
admet-394	60	38	of	of	ADP
admet-394	60	39	other	other	ADJ
admet-394	60	40	influx	influx	NOUN
admet-394	60	41	and	and	CCONJ
admet-394	60	42	efflux	efflux	VERB
admet-394	60	43	transporters	transporter	NOUN
admet-394	60	44	.	.	PUNCT
admet-394	61	1	as	as	ADP
admet-394	61	2	such	such	ADJ
admet-394	61	3	,	,	PUNCT
admet-394	61	4	it	it	PRON
admet-394	61	5	seems	seem	VERB
admet-394	61	6	logical	logical	ADJ
admet-394	61	7	that	that	SCONJ
admet-394	61	8	a	a	DET
admet-394	61	9	well	well	ADV
admet-394	61	10	characterized	characterize	VERB
admet-394	61	11	oct1	oct1	NOUN
admet-394	61	12	transporter	transporter	NOUN
admet-394	61	13	would	would	AUX
admet-394	61	14	be	be	AUX
admet-394	61	15	beneficial	beneficial	ADJ
admet-394	61	16	in	in	ADP
admet-394	61	17	choosing	choose	VERB
admet-394	61	18	the	the	DET
admet-394	61	19	appropriate	appropriate	ADJ
admet-394	61	20	drug	drug	NOUN
admet-394	61	21	,	,	PUNCT
admet-394	61	22	without	without	ADP
admet-394	61	23	competition	competition	NOUN
admet-394	61	24	by	by	ADP
admet-394	61	25	other	other	ADJ
admet-394	61	26	substrates	substrate	NOUN
admet-394	61	27	,	,	PUNCT
admet-394	61	28	for	for	ADP
admet-394	61	29	targeted	target	VERB
admet-394	61	30	entry	entry	NOUN
admet-394	61	31	into	into	ADP
admet-394	61	32	cells	cell	NOUN
admet-394	61	33	.	.	PUNCT
admet-394	62	1	to	to	PART
admet-394	62	2	rapidly	rapidly	ADV
admet-394	62	3	address	address	VERB
admet-394	62	4	these	these	DET
admet-394	62	5	issues	issue	NOUN
admet-394	62	6	,	,	PUNCT
admet-394	62	7	it	it	PRON
admet-394	62	8	would	would	AUX
admet-394	62	9	require	require	VERB
admet-394	62	10	a	a	DET
admet-394	62	11	simple	simple	ADJ
admet-394	62	12	live	live	ADJ
admet-394	62	13	whole	whole	ADJ
admet-394	62	14	model	model	NOUN
admet-394	62	15	system	system	NOUN
admet-394	62	16	that	that	PRON
admet-394	62	17	is	be	AUX
admet-394	62	18	readily	readily	ADV
admet-394	62	19	tenable	tenable	ADJ
admet-394	62	20	to	to	ADP
admet-394	62	21	genetic	genetic	ADJ
admet-394	62	22	modifications	modification	NOUN
admet-394	62	23	and	and	CCONJ
admet-394	62	24	cost	cost	NOUN
admet-394	62	25	effectiveness	effectiveness	NOUN
admet-394	62	26	such	such	ADJ
admet-394	62	27	as	as	ADP
admet-394	62	28	caenorhabditis	caenorhabditis	ADJ
admet-394	62	29	elegans	elegan	NOUN
admet-394	62	30	.	.	PUNCT
admet-394	63	1	admet	admet	PROPN
admet-394	63	2	&	&	CCONJ
admet-394	63	3	dmpk	dmpk	PROPN
admet-394	63	4	5(3	5(3	NUM
admet-394	63	5	)	)	PUNCT
admet-394	63	6	(	(	PUNCT
admet-394	63	7	2017	2017	NUM
admet-394	63	8	)	)	PUNCT
admet-394	63	9	146	146	NUM
admet-394	63	10	-	-	SYM
admet-394	63	11	158	158	NUM
admet-394	63	12	oct-1	oct-1	NUM
admet-394	63	13	and	and	CCONJ
admet-394	63	14	oct-2	oct-2	NUM
admet-394	63	15	in	in	ADP
admet-394	63	16	caenorhabditis	caenorhabditis	PROPN
admet-394	63	17	elegans	elegan	NOUN
admet-394	63	18	doi	doi	NOUN
admet-394	63	19	:	:	PUNCT
admet-394	63	20	10.5599	10.5599	NUM
admet-394	63	21	/	/	SYM
admet-394	63	22	admet.5.3.394	admet.5.3.394	DET
admet-394	63	23	149	149	NUM
admet-394	63	24	c.	c.	NOUN
admet-394	63	25	elegans	elegan	NOUN
admet-394	63	26	as	as	ADP
admet-394	63	27	a	a	DET
admet-394	63	28	model	model	NOUN
admet-394	63	29	to	to	PART
admet-394	63	30	facilitate	facilitate	VERB
admet-394	63	31	studies	study	NOUN
admet-394	63	32	on	on	ADP
admet-394	63	33	drug	drug	NOUN
admet-394	63	34	uptake	uptake	ADJ
admet-394	63	35	transporters	transporter	NOUN
admet-394	63	36	c.	c.	NOUN
admet-394	63	37	elegans	elegan	NOUN
admet-394	63	38	has	have	AUX
admet-394	63	39	been	be	AUX
admet-394	63	40	chosen	choose	VERB
admet-394	63	41	as	as	ADP
admet-394	63	42	the	the	DET
admet-394	63	43	whole	whole	ADJ
admet-394	63	44	model	model	NOUN
admet-394	63	45	system	system	NOUN
admet-394	63	46	as	as	SCONJ
admet-394	63	47	it	it	PRON
admet-394	63	48	offers	offer	VERB
admet-394	63	49	a	a	DET
admet-394	63	50	multitude	multitude	NOUN
admet-394	63	51	of	of	ADP
admet-394	63	52	advantages	advantage	NOUN
admet-394	63	53	over	over	ADP
admet-394	63	54	mammalian	mammalian	ADJ
admet-394	63	55	cells	cell	NOUN
admet-394	63	56	to	to	PART
admet-394	63	57	rapidly	rapidly	ADV
admet-394	63	58	study	study	VERB
admet-394	63	59	many	many	ADJ
admet-394	63	60	highly	highly	ADV
admet-394	63	61	conserved	conserved	ADJ
admet-394	63	62	biological	biological	ADJ
admet-394	63	63	processes	process	NOUN
admet-394	63	64	[	[	X
admet-394	63	65	27	27	NUM
admet-394	63	66	]	]	PUNCT
admet-394	63	67	.	.	PUNCT
admet-394	64	1	c.	c.	PROPN
admet-394	64	2	elegans	elegans	PROPN
admet-394	64	3	developed	develop	VERB
admet-394	64	4	from	from	ADP
admet-394	64	5	eggs	egg	NOUN
admet-394	64	6	to	to	ADP
admet-394	64	7	the	the	DET
admet-394	64	8	adult	adult	NOUN
admet-394	64	9	stage	stage	NOUN
admet-394	64	10	within	within	ADP
admet-394	64	11	three	three	NUM
admet-394	64	12	days	day	NOUN
admet-394	64	13	spanning	span	VERB
admet-394	64	14	four	four	NUM
admet-394	64	15	larval	larval	NOUN
admet-394	64	16	stages	stage	NOUN
admet-394	64	17	.	.	PUNCT
admet-394	65	1	genes	gene	NOUN
admet-394	65	2	can	can	AUX
admet-394	65	3	be	be	AUX
admet-394	65	4	readily	readily	ADV
admet-394	65	5	downregulated	downregulate	VERB
admet-394	65	6	by	by	ADP
admet-394	65	7	simply	simply	ADV
admet-394	65	8	feeding	feed	VERB
admet-394	65	9	the	the	DET
admet-394	65	10	animals	animal	NOUN
admet-394	65	11	with	with	ADP
admet-394	65	12	bacteria	bacteria	NOUN
admet-394	65	13	expressing	express	VERB
admet-394	65	14	double	double	ADJ
admet-394	65	15	stranded	strand	VERB
admet-394	65	16	rna	rna	NOUN
admet-394	65	17	from	from	ADP
admet-394	65	18	a	a	DET
admet-394	65	19	segment	segment	NOUN
admet-394	65	20	of	of	ADP
admet-394	65	21	the	the	DET
admet-394	65	22	coding	code	VERB
admet-394	65	23	region	region	NOUN
admet-394	65	24	of	of	ADP
admet-394	65	25	the	the	DET
admet-394	65	26	targeted	target	VERB
admet-394	65	27	gene	gene	NOUN
admet-394	65	28	.	.	PUNCT
admet-394	66	1	c.	c.	PROPN
admet-394	66	2	elegans	elegans	PROPN
admet-394	66	3	are	be	AUX
admet-394	66	4	transparent	transparent	ADJ
admet-394	66	5	and	and	CCONJ
admet-394	66	6	facilitate	facilitate	VERB
admet-394	66	7	easy	easy	ADJ
admet-394	66	8	visualization	visualization	NOUN
admet-394	66	9	of	of	ADP
admet-394	66	10	germ	germ	NOUN
admet-394	66	11	and	and	CCONJ
admet-394	66	12	somatic	somatic	ADJ
admet-394	66	13	cells	cell	NOUN
admet-394	66	14	by	by	ADP
admet-394	66	15	microscopy	microscopy	NOUN
admet-394	66	16	.	.	PUNCT
admet-394	67	1	during	during	ADP
admet-394	67	2	the	the	DET
admet-394	67	3	last	last	ADJ
admet-394	67	4	decade	decade	NOUN
admet-394	67	5	,	,	PUNCT
admet-394	67	6	c.	c.	PROPN
admet-394	67	7	elegans	elegan	NOUN
admet-394	67	8	have	have	AUX
admet-394	67	9	been	be	AUX
admet-394	67	10	instrumental	instrumental	ADJ
admet-394	67	11	in	in	ADP
admet-394	67	12	several	several	ADJ
admet-394	67	13	drug	drug	NOUN
admet-394	67	14	discovery	discovery	NOUN
admet-394	67	15	programs	program	NOUN
admet-394	67	16	that	that	PRON
admet-394	67	17	include	include	VERB
admet-394	67	18	the	the	DET
admet-394	67	19	search	search	NOUN
admet-394	67	20	for	for	ADP
admet-394	67	21	new	new	ADJ
admet-394	67	22	antifungals	antifungal	NOUN
admet-394	67	23	and	and	CCONJ
admet-394	67	24	compounds	compound	NOUN
admet-394	67	25	to	to	PART
admet-394	67	26	limit	limit	VERB
admet-394	67	27	oxidative	oxidative	ADJ
admet-394	67	28	stress	stress	NOUN
admet-394	67	29	[	[	X
admet-394	67	30	27	27	NUM
admet-394	67	31	,	,	PUNCT
admet-394	67	32	28	28	NUM
admet-394	67	33	]	]	PUNCT
admet-394	67	34	,	,	PUNCT
admet-394	67	35	although	although	SCONJ
admet-394	67	36	the	the	DET
admet-394	67	37	contributions	contribution	NOUN
admet-394	67	38	of	of	ADP
admet-394	67	39	uptake	uptake	ADJ
admet-394	67	40	transporters	transporter	NOUN
admet-394	67	41	in	in	ADP
admet-394	67	42	these	these	DET
admet-394	67	43	studies	study	NOUN
admet-394	67	44	were	be	AUX
admet-394	67	45	not	not	PART
admet-394	67	46	considered	consider	VERB
admet-394	67	47	[	[	PUNCT
admet-394	67	48	29	29	NUM
admet-394	67	49	]	]	PUNCT
admet-394	67	50	.	.	PUNCT
admet-394	68	1	therefore	therefore	ADV
admet-394	68	2	,	,	PUNCT
admet-394	68	3	it	it	PRON
admet-394	68	4	is	be	AUX
admet-394	68	5	unclear	unclear	ADJ
admet-394	68	6	how	how	SCONJ
admet-394	68	7	c.	c.	PROPN
admet-394	68	8	elegans	elegan	NOUN
admet-394	68	9	uptake	uptake	ADJ
admet-394	68	10	transporters	transporter	NOUN
admet-394	68	11	would	would	AUX
admet-394	68	12	have	have	AUX
admet-394	68	13	influenced	influence	VERB
admet-394	68	14	many	many	ADJ
admet-394	68	15	of	of	ADP
admet-394	68	16	the	the	DET
admet-394	68	17	high	high	ADJ
admet-394	68	18	-	-	PUNCT
admet-394	68	19	throughput	throughput	NOUN
admet-394	68	20	screens	screen	NOUN
admet-394	68	21	performed	perform	VERB
admet-394	68	22	so	so	ADV
admet-394	68	23	far	far	ADV
admet-394	68	24	to	to	PART
admet-394	68	25	identify	identify	VERB
admet-394	68	26	novel	novel	ADJ
admet-394	68	27	small	small	ADJ
admet-394	68	28	molecules	molecule	NOUN
admet-394	68	29	that	that	PRON
admet-394	68	30	act	act	VERB
admet-394	68	31	,	,	PUNCT
admet-394	68	32	for	for	ADP
admet-394	68	33	example	example	NOUN
admet-394	68	34	,	,	PUNCT
admet-394	68	35	as	as	ADP
admet-394	68	36	antimicrobials	antimicrobial	NOUN
admet-394	68	37	.	.	PUNCT
admet-394	69	1	one	one	NUM
admet-394	69	2	possibility	possibility	NOUN
admet-394	69	3	is	be	AUX
admet-394	69	4	that	that	SCONJ
admet-394	69	5	the	the	DET
admet-394	69	6	yield	yield	NOUN
admet-394	69	7	of	of	ADP
admet-394	69	8	bioactive	bioactive	ADJ
admet-394	69	9	compounds	compound	NOUN
admet-394	69	10	typically	typically	ADV
admet-394	69	11	recovered	recover	VERB
admet-394	69	12	from	from	ADP
admet-394	69	13	these	these	DET
admet-394	69	14	screens	screen	NOUN
admet-394	69	15	,	,	PUNCT
admet-394	69	16	ranging	range	VERB
admet-394	69	17	from	from	ADP
admet-394	69	18	0.03	0.03	NUM
admet-394	69	19	to	to	ADP
admet-394	69	20	1	1	NUM
admet-394	69	21	%	%	NOUN
admet-394	69	22	,	,	PUNCT
admet-394	69	23	could	could	AUX
admet-394	69	24	be	be	AUX
admet-394	69	25	substantially	substantially	ADV
admet-394	69	26	higher	high	ADJ
admet-394	69	27	if	if	SCONJ
admet-394	69	28	there	there	PRON
admet-394	69	29	is	be	VERB
admet-394	69	30	greater	great	ADJ
admet-394	69	31	influx	influx	NOUN
admet-394	69	32	of	of	ADP
admet-394	69	33	the	the	DET
admet-394	69	34	molecules	molecule	NOUN
admet-394	69	35	into	into	ADP
admet-394	69	36	the	the	DET
admet-394	69	37	animal	animal	NOUN
admet-394	69	38	cells	cell	NOUN
admet-394	69	39	via	via	ADP
admet-394	69	40	elevated	elevated	ADJ
admet-394	69	41	expression	expression	NOUN
admet-394	69	42	of	of	ADP
admet-394	69	43	uptake	uptake	ADJ
admet-394	69	44	transporters	transporter	NOUN
admet-394	69	45	[	[	X
admet-394	69	46	27	27	NUM
admet-394	69	47	,	,	PUNCT
admet-394	69	48	30	30	NUM
admet-394	69	49	]	]	PUNCT
admet-394	69	50	.	.	PUNCT
admet-394	70	1	thus	thus	ADV
admet-394	70	2	,	,	PUNCT
admet-394	70	3	defining	define	VERB
admet-394	70	4	the	the	DET
admet-394	70	5	function	function	NOUN
admet-394	70	6	and	and	CCONJ
admet-394	70	7	substrate	substrate	NOUN
admet-394	70	8	specificities	specificity	NOUN
admet-394	70	9	of	of	ADP
admet-394	70	10	uptake	uptake	ADJ
admet-394	70	11	transporters	transporter	NOUN
admet-394	70	12	in	in	ADP
admet-394	70	13	c.	c.	PROPN
admet-394	70	14	elegans	elegans	PROPN
admet-394	70	15	will	will	AUX
admet-394	70	16	be	be	AUX
admet-394	70	17	advantageous	advantageous	ADJ
admet-394	70	18	towards	towards	ADP
admet-394	70	19	improving	improve	VERB
admet-394	70	20	the	the	DET
admet-394	70	21	strategies	strategy	NOUN
admet-394	70	22	employed	employ	VERB
admet-394	70	23	to	to	PART
admet-394	70	24	identify	identify	VERB
admet-394	70	25	novel	novel	ADJ
admet-394	70	26	bioactive	bioactive	ADJ
admet-394	70	27	molecules	molecule	NOUN
admet-394	70	28	.	.	PUNCT
admet-394	71	1	highlighted	highlight	VERB
admet-394	71	2	below	below	ADV
admet-394	71	3	are	be	AUX
admet-394	71	4	the	the	DET
admet-394	71	5	current	current	ADJ
admet-394	71	6	progresses	progress	NOUN
admet-394	71	7	regarding	regard	VERB
admet-394	71	8	the	the	DET
admet-394	71	9	roles	role	NOUN
admet-394	71	10	of	of	ADP
admet-394	71	11	a	a	DET
admet-394	71	12	previously	previously	ADV
admet-394	71	13	and	and	CCONJ
admet-394	71	14	a	a	DET
admet-394	71	15	recently	recently	ADV
admet-394	71	16	discovered	discover	VERB
admet-394	71	17	organic	organic	ADJ
admet-394	71	18	cation	cation	NOUN
admet-394	71	19	transporter	transporter	NOUN
admet-394	71	20	,	,	PUNCT
admet-394	71	21	oct-1	oct-1	NUM
admet-394	71	22	and	and	CCONJ
admet-394	71	23	oct-2	oct-2	NUM
admet-394	71	24	,	,	PUNCT
admet-394	71	25	respectively	respectively	ADV
admet-394	71	26	,	,	PUNCT
admet-394	71	27	in	in	ADP
admet-394	71	28	c.	c.	PROPN
admet-394	71	29	elegans	elegan	NOUN
admet-394	71	30	and	and	CCONJ
admet-394	71	31	how	how	SCONJ
admet-394	71	32	these	these	DET
admet-394	71	33	transporters	transporter	NOUN
admet-394	71	34	can	can	AUX
admet-394	71	35	be	be	AUX
admet-394	71	36	exploited	exploit	VERB
admet-394	71	37	for	for	ADP
admet-394	71	38	drug	drug	NOUN
admet-394	71	39	testing	testing	NOUN
admet-394	71	40	.	.	PUNCT
admet-394	72	1	uptake	uptake	ADJ
admet-394	72	2	transporters	transporter	NOUN
admet-394	72	3	in	in	ADP
admet-394	72	4	c.	c.	PROPN
admet-394	72	5	elegans	elegan	NOUN
admet-394	72	6	in	in	ADP
admet-394	72	7	comparison	comparison	NOUN
admet-394	72	8	to	to	ADP
admet-394	72	9	the	the	DET
admet-394	72	10	human	human	ADJ
admet-394	72	11	genome	genome	NOUN
admet-394	72	12	,	,	PUNCT
admet-394	72	13	there	there	PRON
admet-394	72	14	are	be	VERB
admet-394	72	15	far	far	ADV
admet-394	72	16	fewer	few	ADJ
admet-394	72	17	organic	organic	ADJ
admet-394	72	18	cation	cation	NOUN
admet-394	72	19	transporters	transporter	NOUN
admet-394	72	20	in	in	ADP
admet-394	72	21	c.	c.	PROPN
admet-394	72	22	elegans	elegan	NOUN
admet-394	72	23	following	follow	VERB
admet-394	72	24	an	an	DET
admet-394	72	25	analysis	analysis	NOUN
admet-394	72	26	of	of	ADP
admet-394	72	27	the	the	DET
admet-394	72	28	sequence	sequence	NOUN
admet-394	72	29	information	information	NOUN
admet-394	72	30	in	in	ADP
admet-394	72	31	the	the	DET
admet-394	72	32	wormbase	wormbase	NOUN
admet-394	72	33	.	.	PUNCT
admet-394	73	1	these	these	DET
admet-394	73	2	c.	c.	PROPN
admet-394	73	3	elegans	elegan	NOUN
admet-394	73	4	transporters	transporter	NOUN
admet-394	73	5	include	include	VERB
admet-394	73	6	the	the	DET
admet-394	73	7	partially	partially	ADV
admet-394	73	8	characterized	characterize	VERB
admet-394	73	9	oct-1	oct-1	ADV
admet-394	73	10	and	and	CCONJ
admet-394	73	11	oct-2	oct-2	NUM
admet-394	73	12	and	and	CCONJ
admet-394	73	13	at	at	ADV
admet-394	73	14	least	least	ADJ
admet-394	73	15	six	six	NUM
admet-394	73	16	other	other	ADJ
admet-394	73	17	putative	putative	ADJ
admet-394	73	18	transmembrane	transmembrane	NOUN
admet-394	73	19	transporters	transporter	NOUN
admet-394	73	20	pes-23	pes-23	NOUN
admet-394	73	21	,	,	PUNCT
admet-394	73	22	oat-1	oat-1	X
admet-394	73	23	,	,	PUNCT
admet-394	73	24	svop-1	svop-1	PROPN
admet-394	73	25	,	,	PUNCT
admet-394	73	26	str-176	str-176	NOUN
admet-394	73	27	,	,	PUNCT
admet-394	73	28	hmt-1.1/1.2	hmt-1.1/1.2	NOUN
admet-394	73	29	and	and	CCONJ
admet-394	73	30	gem-1	gem-1	NOUN
admet-394	73	31	.	.	PUNCT
admet-394	74	1	far	far	ADV
admet-394	74	2	less	less	ADV
admet-394	74	3	is	be	AUX
admet-394	74	4	known	know	VERB
admet-394	74	5	about	about	ADP
admet-394	74	6	these	these	DET
admet-394	74	7	latter	latter	ADJ
admet-394	74	8	six	six	NUM
admet-394	74	9	putative	putative	ADJ
admet-394	74	10	transporters	transporter	NOUN
admet-394	74	11	and	and	CCONJ
admet-394	74	12	will	will	AUX
admet-394	74	13	not	not	PART
admet-394	74	14	be	be	AUX
admet-394	74	15	discussed	discuss	VERB
admet-394	74	16	further	far	ADV
admet-394	74	17	.	.	PUNCT
admet-394	75	1	the	the	DET
admet-394	75	2	c.	c.	PROPN
admet-394	75	3	elegans	elegan	NOUN
admet-394	75	4	oct-1	oct-1	ADV
admet-394	75	5	and	and	CCONJ
admet-394	75	6	oct-2	oct-2	NUM
admet-394	75	7	are	be	AUX
admet-394	75	8	counterparts	counterpart	NOUN
admet-394	75	9	of	of	ADP
admet-394	75	10	the	the	DET
admet-394	75	11	human	human	ADJ
admet-394	75	12	octs	oct	NOUN
admet-394	75	13	and	and	CCONJ
admet-394	75	14	little	little	ADJ
admet-394	75	15	is	be	AUX
admet-394	75	16	still	still	ADV
admet-394	75	17	known	know	VERB
admet-394	75	18	about	about	ADP
admet-394	75	19	their	their	PRON
admet-394	75	20	roles	role	NOUN
admet-394	75	21	and	and	CCONJ
admet-394	75	22	affinities	affinity	NOUN
admet-394	75	23	towards	towards	ADP
admet-394	75	24	distinct	distinct	ADJ
admet-394	75	25	ligands	ligand	NOUN
admet-394	75	26	.	.	PUNCT
admet-394	76	1	both	both	DET
admet-394	76	2	oct-1	oct-1	ADV
admet-394	76	3	and	and	CCONJ
admet-394	76	4	oct-2	oct-2	NUM
admet-394	76	5	share	share	VERB
admet-394	76	6	22.56	22.56	NUM
admet-394	76	7	%	%	NOUN
admet-394	76	8	identity	identity	NOUN
admet-394	76	9	at	at	ADP
admet-394	76	10	the	the	DET
admet-394	76	11	amino	amino	NOUN
admet-394	76	12	acid	acid	NOUN
admet-394	76	13	level	level	NOUN
admet-394	76	14	,	,	PUNCT
admet-394	76	15	but	but	CCONJ
admet-394	76	16	oct-2	oct-2	NUM
admet-394	76	17	differs	differ	VERB
admet-394	76	18	from	from	ADP
admet-394	76	19	oct-1	oct-1	PRON
admet-394	76	20	as	as	SCONJ
admet-394	76	21	it	it	PRON
admet-394	76	22	harbours	harbour	VERB
admet-394	76	23	an	an	DET
admet-394	76	24	extra	extra	ADJ
admet-394	76	25	172	172	NUM
admet-394	76	26	amino	amino	NOUN
admet-394	76	27	acid	acid	NOUN
admet-394	76	28	residues	residue	NOUN
admet-394	76	29	at	at	ADP
admet-394	76	30	the	the	DET
admet-394	76	31	n	n	CCONJ
admet-394	76	32	-	-	PUNCT
admet-394	76	33	terminal	terminal	NOUN
admet-394	76	34	,	,	PUNCT
admet-394	76	35	which	which	PRON
admet-394	76	36	has	have	VERB
admet-394	76	37	no	no	DET
admet-394	76	38	homology	homology	NOUN
admet-394	76	39	to	to	ADP
admet-394	76	40	oct-1	oct-1	NOUN
admet-394	76	41	.	.	PUNCT
admet-394	77	1	in	in	ADP
admet-394	77	2	1999	1999	NUM
admet-394	77	3	,	,	PUNCT
admet-394	77	4	oct-1	oct-1	NUM
admet-394	77	5	was	be	AUX
admet-394	77	6	the	the	DET
admet-394	77	7	first	first	ADJ
admet-394	77	8	uptake	uptake	ADJ
admet-394	77	9	transporter	transporter	NOUN
admet-394	77	10	identified	identify	VERB
admet-394	77	11	from	from	ADP
admet-394	77	12	c.	c.	NOUN
admet-394	77	13	elegans	elegan	NOUN
admet-394	77	14	[	[	X
admet-394	77	15	31	31	NUM
admet-394	77	16	]	]	PUNCT
admet-394	77	17	.	.	PUNCT
admet-394	78	1	the	the	DET
admet-394	78	2	oct-1	oct-1	PUNCT
admet-394	78	3	gene	gene	NOUN
admet-394	78	4	was	be	AUX
admet-394	78	5	designed	design	VERB
admet-394	78	6	to	to	PART
admet-394	78	7	be	be	AUX
admet-394	78	8	expressed	express	VERB
admet-394	78	9	in	in	ADP
admet-394	78	10	mammalian	mammalian	ADJ
admet-394	78	11	cells	cell	NOUN
admet-394	78	12	and	and	CCONJ
admet-394	78	13	shown	show	VERB
admet-394	78	14	to	to	PART
admet-394	78	15	mediate	mediate	VERB
admet-394	78	16	the	the	DET
admet-394	78	17	transport	transport	NOUN
admet-394	78	18	of	of	ADP
admet-394	78	19	the	the	DET
admet-394	78	20	organic	organic	ADJ
admet-394	78	21	cation	cation	NOUN
admet-394	78	22	tetraethylammonium	tetraethylammonium	NOUN
admet-394	78	23	,	,	PUNCT
admet-394	78	24	a	a	DET
admet-394	78	25	prototypical	prototypical	ADJ
admet-394	78	26	substrate	substrate	NOUN
admet-394	78	27	used	use	VERB
admet-394	78	28	for	for	ADP
admet-394	78	29	classifying	classify	VERB
admet-394	78	30	octs	oct	NOUN
admet-394	78	31	,	,	PUNCT
admet-394	78	32	suggesting	suggest	VERB
admet-394	78	33	that	that	SCONJ
admet-394	78	34	oct-1	oct-1	ADV
admet-394	78	35	has	have	VERB
admet-394	78	36	the	the	DET
admet-394	78	37	ability	ability	NOUN
admet-394	78	38	to	to	PART
admet-394	78	39	function	function	VERB
admet-394	78	40	as	as	ADP
admet-394	78	41	an	an	DET
admet-394	78	42	uptake	uptake	ADJ
admet-394	78	43	transporter	transporter	NOUN
admet-394	78	44	[	[	X
admet-394	78	45	31	31	NUM
admet-394	78	46	]	]	PUNCT
admet-394	78	47	.	.	PUNCT
admet-394	79	1	at	at	ADP
admet-394	79	2	the	the	DET
admet-394	79	3	time	time	NOUN
admet-394	79	4	,	,	PUNCT
admet-394	79	5	no	no	DET
admet-394	79	6	extensive	extensive	ADJ
admet-394	79	7	study	study	NOUN
admet-394	79	8	was	be	AUX
admet-394	79	9	done	do	VERB
admet-394	79	10	to	to	PART
admet-394	79	11	assess	assess	VERB
admet-394	79	12	the	the	DET
admet-394	79	13	detail	detail	NOUN
admet-394	79	14	substrate	substrate	NOUN
admet-394	79	15	specificity	specificity	NOUN
admet-394	79	16	of	of	ADP
admet-394	79	17	oct-1	oct-1	ADV
admet-394	79	18	following	follow	VERB
admet-394	79	19	its	its	PRON
admet-394	79	20	expression	expression	NOUN
admet-394	79	21	in	in	ADP
admet-394	79	22	human	human	ADJ
admet-394	79	23	cells	cell	NOUN
admet-394	79	24	.	.	PUNCT
admet-394	80	1	it	it	PRON
admet-394	80	2	was	be	AUX
admet-394	80	3	much	much	ADV
admet-394	80	4	later	later	ADV
admet-394	80	5	when	when	SCONJ
admet-394	80	6	the	the	DET
admet-394	80	7	next	next	ADJ
admet-394	80	8	study	study	NOUN
admet-394	80	9	appeared	appear	VERB
admet-394	80	10	in	in	ADP
admet-394	80	11	2013	2013	NUM
admet-394	80	12	showing	show	VERB
admet-394	80	13	that	that	SCONJ
admet-394	80	14	c.	c.	NOUN
admet-394	80	15	elegans	elegan	NOUN
admet-394	80	16	deleted	delete	VERB
admet-394	80	17	for	for	ADP
admet-394	80	18	the	the	DET
admet-394	80	19	oct-1	oct-1	PUNCT
admet-394	80	20	gene	gene	NOUN
admet-394	80	21	exhibited	exhibit	VERB
admet-394	80	22	a	a	DET
admet-394	80	23	shortened	shorten	VERB
admet-394	80	24	lifespan	lifespan	NOUN
admet-394	80	25	,	,	PUNCT
admet-394	80	26	as	as	ADV
admet-394	80	27	well	well	ADV
admet-394	80	28	as	as	ADP
admet-394	80	29	an	an	DET
admet-394	80	30	increased	increase	VERB
admet-394	80	31	susceptibility	susceptibility	NOUN
admet-394	80	32	to	to	PART
admet-394	80	33	oxidative	oxidative	VERB
admet-394	80	34	stress	stress	NOUN
admet-394	80	35	[	[	X
admet-394	80	36	29	29	NUM
admet-394	80	37	]	]	PUNCT
admet-394	80	38	.	.	PUNCT
admet-394	81	1	these	these	DET
admet-394	81	2	observations	observation	NOUN
admet-394	81	3	led	lead	VERB
admet-394	81	4	to	to	ADP
admet-394	81	5	the	the	DET
admet-394	81	6	proposition	proposition	NOUN
admet-394	81	7	that	that	PRON
admet-394	81	8	oct-1	oct-1	ADV
admet-394	81	9	facilitates	facilitate	VERB
admet-394	81	10	the	the	DET
admet-394	81	11	import	import	NOUN
admet-394	81	12	of	of	ADP
admet-394	81	13	antioxidants	antioxidant	NOUN
admet-394	81	14	into	into	ADP
admet-394	81	15	the	the	DET
admet-394	81	16	animals	animal	NOUN
admet-394	81	17	,	,	PUNCT
admet-394	81	18	which	which	PRON
admet-394	81	19	is	be	AUX
admet-394	81	20	required	require	VERB
admet-394	81	21	to	to	PART
admet-394	81	22	protect	protect	VERB
admet-394	81	23	oct-1	oct-1	X
admet-394	81	24	mutant	mutant	ADJ
admet-394	81	25	animals	animal	NOUN
admet-394	81	26	from	from	ADP
admet-394	81	27	oxidative	oxidative	ADJ
admet-394	81	28	stress	stress	NOUN
admet-394	81	29	[	[	X
admet-394	81	30	29	29	NUM
admet-394	81	31	]	]	PUNCT
admet-394	81	32	.	.	PUNCT
admet-394	82	1	however	however	ADV
admet-394	82	2	,	,	PUNCT
admet-394	82	3	the	the	DET
admet-394	82	4	level	level	NOUN
admet-394	82	5	of	of	ADP
admet-394	82	6	the	the	DET
admet-394	82	7	purported	purport	VERB
admet-394	82	8	substrate	substrate	NOUN
admet-394	82	9	of	of	ADP
admet-394	82	10	oct-1	oct-1	PRON
admet-394	82	11	,	,	PUNCT
admet-394	82	12	the	the	DET
admet-394	82	13	antioxidant	antioxidant	ADJ
admet-394	82	14	ergothioneine	ergothioneine	NOUN
admet-394	82	15	,	,	PUNCT
admet-394	82	16	was	be	AUX
admet-394	82	17	not	not	PART
admet-394	82	18	altered	alter	VERB
admet-394	82	19	in	in	ADP
admet-394	82	20	oct-1	oct-1	PUNCT
admet-394	82	21	mutant	mutant	ADJ
admet-394	82	22	animals	animal	NOUN
admet-394	82	23	as	as	ADP
admet-394	82	24	compared	compare	VERB
admet-394	82	25	to	to	ADP
admet-394	82	26	the	the	DET
admet-394	82	27	parent	parent	NOUN
admet-394	82	28	[	[	X
admet-394	82	29	29	29	NUM
admet-394	82	30	]	]	PUNCT
admet-394	82	31	.	.	PUNCT
admet-394	83	1	therefore	therefore	ADV
admet-394	83	2	,	,	PUNCT
admet-394	83	3	it	it	PRON
admet-394	83	4	seems	seem	VERB
admet-394	83	5	plausible	plausible	ADJ
admet-394	83	6	that	that	SCONJ
admet-394	83	7	an	an	DET
admet-394	83	8	alternative	alternative	ADJ
admet-394	83	9	explanation	explanation	NOUN
admet-394	83	10	could	could	AUX
admet-394	83	11	account	account	VERB
admet-394	83	12	for	for	ADP
admet-394	83	13	the	the	DET
admet-394	83	14	oct-1	oct-1	ADV
admet-394	83	15	mutant	mutant	ADJ
admet-394	83	16	animal	animal	NOUN
admet-394	83	17	phenotypes	phenotype	NOUN
admet-394	83	18	.	.	PUNCT
admet-394	84	1	in	in	ADP
admet-394	84	2	an	an	DET
admet-394	84	3	attempt	attempt	NOUN
admet-394	84	4	to	to	PART
admet-394	84	5	find	find	VERB
admet-394	84	6	substrates	substrate	NOUN
admet-394	84	7	for	for	ADP
admet-394	84	8	oct-1	oct-1	PRON
admet-394	84	9	,	,	PUNCT
admet-394	84	10	we	we	PRON
admet-394	84	11	expressed	express	VERB
admet-394	84	12	the	the	DET
admet-394	84	13	c.	c.	PROPN
admet-394	84	14	elegans	elegan	NOUN
admet-394	84	15	oct-1	oct-1	PART
admet-394	84	16	gene	gene	NOUN
admet-394	84	17	in	in	ADP
admet-394	84	18	another	another	DET
admet-394	84	19	heterologous	heterologous	ADJ
admet-394	84	20	model	model	NOUN
admet-394	84	21	system	system	NOUN
admet-394	84	22	,	,	PUNCT
admet-394	84	23	namely	namely	ADV
admet-394	84	24	the	the	DET
admet-394	84	25	budding	bud	VERB
admet-394	84	26	yeast	yeast	NOUN
admet-394	84	27	saccharomyces	saccharomyce	NOUN
admet-394	84	28	cerevisiae	cerevisiae	NOUN
admet-394	84	29	.	.	PUNCT
admet-394	85	1	since	since	SCONJ
admet-394	85	2	human	human	ADJ
admet-394	85	3	oct1	oct1	NOUN
admet-394	85	4	can	can	AUX
admet-394	85	5	dindial	dindial	VERB
admet-394	85	6	ramotar	ramotar	PROPN
admet-394	85	7	admet	admet	PROPN
admet-394	85	8	&	&	CCONJ
admet-394	85	9	dmpk	dmpk	PROPN
admet-394	85	10	5(3	5(3	NUM
admet-394	85	11	)	)	PUNCT
admet-394	85	12	(	(	PUNCT
admet-394	85	13	2017	2017	NUM
admet-394	85	14	)	)	PUNCT
admet-394	85	15	146	146	NUM
admet-394	85	16	-	-	SYM
admet-394	85	17	158	158	NUM
admet-394	85	18	150	150	NUM
admet-394	85	19	transport	transport	NOUN
admet-394	85	20	anthracyclines	anthracycline	NOUN
admet-394	85	21	,	,	PUNCT
admet-394	85	22	we	we	PRON
admet-394	85	23	first	first	ADV
admet-394	85	24	tested	test	VERB
admet-394	85	25	these	these	DET
admet-394	85	26	chemotherapeutic	chemotherapeutic	ADJ
admet-394	85	27	drugs	drug	NOUN
admet-394	85	28	.	.	PUNCT
admet-394	86	1	we	we	PRON
admet-394	86	2	observed	observe	VERB
admet-394	86	3	that	that	SCONJ
admet-394	86	4	expression	expression	NOUN
admet-394	86	5	of	of	ADP
admet-394	86	6	c.	c.	PROPN
admet-394	86	7	elegans	elegan	NOUN
admet-394	86	8	oct-1	oct-1	ADV
admet-394	86	9	can	can	AUX
admet-394	86	10	trigger	trigger	VERB
admet-394	86	11	the	the	DET
admet-394	86	12	uptake	uptake	NOUN
admet-394	86	13	of	of	ADP
admet-394	86	14	doxorubicin	doxorubicin	NOUN
admet-394	86	15	into	into	ADP
admet-394	86	16	yeast	yeast	NOUN
admet-394	86	17	cells	cell	NOUN
admet-394	86	18	.	.	PUNCT
admet-394	87	1	the	the	DET
admet-394	87	2	yeast	yeast	NOUN
admet-394	87	3	strain	strain	NOUN
admet-394	87	4	we	we	PRON
admet-394	87	5	used	use	VERB
admet-394	87	6	was	be	AUX
admet-394	87	7	defective	defective	ADJ
admet-394	87	8	in	in	ADP
admet-394	87	9	agp2	agp2	PROPN
admet-394	87	10	,	,	PUNCT
admet-394	87	11	which	which	PRON
admet-394	87	12	has	have	AUX
admet-394	87	13	been	be	AUX
admet-394	87	14	reported	report	VERB
admet-394	87	15	to	to	PART
admet-394	87	16	be	be	AUX
admet-394	87	17	a	a	DET
admet-394	87	18	plasma	plasma	NOUN
admet-394	87	19	membrane	membrane	NOUN
admet-394	87	20	amino	amino	NOUN
admet-394	87	21	acid	acid	NOUN
admet-394	87	22	transporter	transporter	NOUN
admet-394	87	23	that	that	PRON
admet-394	87	24	also	also	ADV
admet-394	87	25	performs	perform	VERB
admet-394	87	26	a	a	DET
admet-394	87	27	regulatory	regulatory	ADJ
admet-394	87	28	role	role	NOUN
admet-394	87	29	[	[	X
admet-394	87	30	32	32	NUM
admet-394	87	31	]	]	PUNCT
admet-394	87	32	.	.	PUNCT
admet-394	88	1	deletion	deletion	NOUN
admet-394	88	2	of	of	ADP
admet-394	88	3	the	the	DET
admet-394	88	4	agp2	agp2	PROPN
admet-394	88	5	gene	gene	NOUN
admet-394	88	6	in	in	ADP
admet-394	88	7	yeast	yeast	NOUN
admet-394	88	8	blocked	block	VERB
admet-394	88	9	the	the	DET
admet-394	88	10	expression	expression	NOUN
admet-394	88	11	of	of	ADP
admet-394	88	12	several	several	ADJ
admet-394	88	13	target	target	NOUN
admet-394	88	14	genes	gene	NOUN
admet-394	88	15	including	include	VERB
admet-394	88	16	the	the	DET
admet-394	88	17	polyamine	polyamine	NOUN
admet-394	88	18	transporters	transporter	NOUN
admet-394	88	19	dur3	dur3	VERB
admet-394	88	20	and	and	CCONJ
admet-394	88	21	sam3	sam3	PROPN
admet-394	89	1	[	[	X
admet-394	89	2	18	18	NUM
admet-394	89	3	]	]	PUNCT
admet-394	89	4	.	.	PUNCT
admet-394	90	1	both	both	PRON
admet-394	90	2	dur3	dur3	PROPN
admet-394	90	3	and	and	CCONJ
admet-394	90	4	sam3	sam3	PROPN
admet-394	90	5	can	can	AUX
admet-394	90	6	independently	independently	ADV
admet-394	90	7	transport	transport	VERB
admet-394	90	8	doxorubicin	doxorubicin	PROPN
admet-394	90	9	when	when	SCONJ
admet-394	90	10	overexpressed	overexpresse	VERB
admet-394	90	11	in	in	ADP
admet-394	90	12	yeast	yeast	NOUN
admet-394	90	13	cells	cell	NOUN
admet-394	90	14	lacking	lack	VERB
admet-394	90	15	agp2	agp2	PROPN
admet-394	91	1	[	[	X
admet-394	91	2	18	18	NUM
admet-394	91	3	]	]	PUNCT
admet-394	91	4	.	.	PUNCT
admet-394	92	1	therefore	therefore	ADV
admet-394	92	2	,	,	PUNCT
admet-394	92	3	it	it	PRON
admet-394	92	4	is	be	AUX
admet-394	92	5	not	not	PART
admet-394	92	6	clear	clear	ADJ
admet-394	92	7	whether	whether	SCONJ
admet-394	92	8	the	the	DET
admet-394	92	9	expression	expression	NOUN
admet-394	92	10	of	of	ADP
admet-394	92	11	c.	c.	PROPN
admet-394	92	12	elegans	elegan	NOUN
admet-394	92	13	oct-1	oct-1	ADV
admet-394	92	14	in	in	ADP
admet-394	92	15	yeast	yeast	NOUN
admet-394	92	16	substituted	substitute	VERB
admet-394	92	17	for	for	ADP
admet-394	92	18	the	the	DET
admet-394	92	19	regulatory	regulatory	ADJ
admet-394	92	20	function	function	NOUN
admet-394	92	21	of	of	ADP
admet-394	92	22	agp2	agp2	PROPN
admet-394	92	23	or	or	CCONJ
admet-394	92	24	directly	directly	ADV
admet-394	92	25	for	for	ADP
admet-394	92	26	the	the	DET
admet-394	92	27	roles	role	NOUN
admet-394	92	28	of	of	ADP
admet-394	92	29	dur3	dur3	PROPN
admet-394	92	30	and	and	CCONJ
admet-394	92	31	sam3	sam3	PROPN
admet-394	92	32	,	,	PUNCT
admet-394	92	33	since	since	SCONJ
admet-394	92	34	these	these	DET
admet-394	92	35	transporters	transporter	NOUN
admet-394	92	36	also	also	ADV
admet-394	92	37	mediate	mediate	VERB
admet-394	92	38	uptake	uptake	ADJ
admet-394	92	39	of	of	ADP
admet-394	92	40	doxorubicin	doxorubicin	PROPN
admet-394	92	41	[	[	X
admet-394	92	42	18	18	NUM
admet-394	92	43	]	]	PUNCT
admet-394	92	44	.	.	PUNCT
admet-394	93	1	as	as	ADP
admet-394	93	2	such	such	ADJ
admet-394	93	3	,	,	PUNCT
admet-394	93	4	it	it	PRON
admet-394	93	5	became	become	VERB
admet-394	93	6	necessary	necessary	ADJ
admet-394	93	7	to	to	PART
admet-394	93	8	test	test	VERB
admet-394	93	9	directly	directly	ADV
admet-394	93	10	whether	whether	SCONJ
admet-394	93	11	oct-1	oct-1	PRON
admet-394	93	12	might	might	AUX
admet-394	93	13	mediate	mediate	VERB
admet-394	93	14	the	the	DET
admet-394	93	15	transport	transport	NOUN
admet-394	93	16	of	of	ADP
admet-394	93	17	doxorubicin	doxorubicin	PROPN
admet-394	93	18	into	into	ADP
admet-394	93	19	c.	c.	PROPN
admet-394	93	20	elegans	elegans	PROPN
admet-394	93	21	.	.	PUNCT
admet-394	94	1	however	however	ADV
admet-394	94	2	,	,	PUNCT
admet-394	94	3	the	the	DET
admet-394	94	4	existence	existence	NOUN
admet-394	94	5	of	of	ADP
admet-394	94	6	another	another	DET
admet-394	94	7	related	related	ADJ
admet-394	94	8	member	member	NOUN
admet-394	94	9	of	of	ADP
admet-394	94	10	the	the	DET
admet-394	94	11	organic	organic	ADJ
admet-394	94	12	cation	cation	NOUN
admet-394	94	13	transporter	transporter	NOUN
admet-394	94	14	family	family	NOUN
admet-394	94	15	,	,	PUNCT
admet-394	94	16	namely	namely	ADV
admet-394	94	17	oct-2	oct-2	NOUN
admet-394	94	18	,	,	PUNCT
admet-394	94	19	in	in	ADP
admet-394	94	20	c.	c.	PROPN
admet-394	94	21	elegans	elegan	NOUN
admet-394	94	22	,	,	PUNCT
admet-394	94	23	suggests	suggest	VERB
admet-394	94	24	that	that	SCONJ
admet-394	94	25	there	there	PRON
admet-394	94	26	needs	need	VERB
admet-394	94	27	to	to	PART
admet-394	94	28	be	be	AUX
admet-394	94	29	a	a	DET
admet-394	94	30	strategy	strategy	NOUN
admet-394	94	31	to	to	PART
admet-394	94	32	test	test	VERB
admet-394	94	33	the	the	DET
admet-394	94	34	contribution	contribution	NOUN
admet-394	94	35	of	of	ADP
admet-394	94	36	each	each	DET
admet-394	94	37	transporter	transporter	NOUN
admet-394	94	38	towards	towards	ADP
admet-394	94	39	doxorubicin	doxorubicin	PROPN
admet-394	94	40	uptake	uptake	VERB
admet-394	94	41	.	.	PUNCT
admet-394	95	1	prior	prior	ADV
admet-394	95	2	to	to	ADP
admet-394	95	3	our	our	PRON
admet-394	95	4	work	work	NOUN
admet-394	95	5	,	,	PUNCT
admet-394	95	6	there	there	PRON
admet-394	95	7	was	be	VERB
admet-394	95	8	no	no	DET
admet-394	95	9	function	function	NOUN
admet-394	95	10	assigned	assign	VERB
admet-394	95	11	to	to	ADP
admet-394	95	12	this	this	DET
admet-394	95	13	putative	putative	ADJ
admet-394	95	14	transporter	transporter	NOUN
admet-394	95	15	oct-2	oct-2	ADP
admet-394	95	16	[	[	X
admet-394	95	17	33	33	NUM
admet-394	95	18	]	]	PUNCT
admet-394	95	19	.	.	PUNCT
admet-394	96	1	moreover	moreover	ADV
admet-394	96	2	,	,	PUNCT
admet-394	96	3	there	there	PRON
admet-394	96	4	are	be	VERB
admet-394	96	5	no	no	DET
admet-394	96	6	animals	animal	NOUN
admet-394	96	7	in	in	ADP
admet-394	96	8	the	the	DET
admet-394	96	9	consortiums	consortium	NOUN
admet-394	96	10	,	,	PUNCT
admet-394	96	11	usa	usa	PROPN
admet-394	96	12	or	or	CCONJ
admet-394	96	13	japan	japan	PROPN
admet-394	96	14	,	,	PUNCT
admet-394	96	15	carrying	carry	VERB
admet-394	96	16	either	either	CCONJ
admet-394	96	17	partial	partial	ADJ
admet-394	96	18	or	or	CCONJ
admet-394	96	19	complete	complete	ADJ
admet-394	96	20	deletion	deletion	NOUN
admet-394	96	21	of	of	ADP
admet-394	96	22	the	the	DET
admet-394	96	23	oct-2	oct-2	NUM
admet-394	96	24	gene	gene	NOUN
admet-394	96	25	,	,	PUNCT
admet-394	96	26	as	as	ADP
admet-394	96	27	in	in	ADP
admet-394	96	28	the	the	DET
admet-394	96	29	case	case	NOUN
admet-394	96	30	of	of	ADP
admet-394	96	31	oct-1	oct-1	PRON
admet-394	96	32	.	.	PUNCT
admet-394	97	1	thus	thus	ADV
admet-394	97	2	,	,	PUNCT
admet-394	97	3	to	to	PART
admet-394	97	4	examine	examine	VERB
admet-394	97	5	whether	whether	SCONJ
admet-394	97	6	oct-1	oct-1	ADV
admet-394	97	7	or	or	CCONJ
admet-394	97	8	oct-2	oct-2	NUM
admet-394	97	9	or	or	CCONJ
admet-394	97	10	both	both	PRON
admet-394	97	11	have	have	VERB
admet-394	97	12	roles	role	NOUN
admet-394	97	13	in	in	ADP
admet-394	97	14	the	the	DET
admet-394	97	15	uptake	uptake	NOUN
admet-394	97	16	of	of	ADP
admet-394	97	17	doxorubicin	doxorubicin	PROPN
admet-394	97	18	in	in	ADP
admet-394	97	19	c.	c.	PROPN
admet-394	97	20	elegans	elegans	PROPN
admet-394	97	21	,	,	PUNCT
admet-394	97	22	we	we	PRON
admet-394	97	23	used	use	VERB
admet-394	97	24	rna	rna	NOUN
admet-394	97	25	-	-	PUNCT
admet-394	97	26	interference	interference	NOUN
admet-394	97	27	(	(	PUNCT
admet-394	97	28	rnai	rnai	PROPN
admet-394	97	29	)	)	PUNCT
admet-394	97	30	feeding	feed	VERB
admet-394	97	31	bacteria	bacteria	NOUN
admet-394	97	32	to	to	PART
admet-394	97	33	generate	generate	VERB
admet-394	97	34	animals	animal	NOUN
admet-394	97	35	with	with	ADP
admet-394	97	36	different	different	ADJ
admet-394	97	37	genotypes	genotype	NOUN
admet-394	97	38	,	,	PUNCT
admet-394	97	39	in	in	ADP
admet-394	97	40	particular	particular	ADJ
admet-394	97	41	,	,	PUNCT
admet-394	97	42	either	either	CCONJ
admet-394	97	43	downregulated	downregulate	VERB
admet-394	97	44	for	for	ADP
admet-394	97	45	one	one	NUM
admet-394	97	46	or	or	CCONJ
admet-394	97	47	both	both	DET
admet-394	97	48	transporters	transporter	NOUN
admet-394	98	1	[	[	X
admet-394	98	2	33	33	NUM
admet-394	98	3	]	]	PUNCT
admet-394	98	4	.	.	PUNCT
admet-394	99	1	using	use	VERB
admet-394	99	2	this	this	DET
admet-394	99	3	approach	approach	NOUN
admet-394	99	4	,	,	PUNCT
admet-394	99	5	we	we	PRON
admet-394	99	6	uncovered	uncover	VERB
admet-394	99	7	several	several	ADJ
admet-394	99	8	novel	novel	ADJ
admet-394	99	9	findings	finding	NOUN
admet-394	99	10	regarding	regard	VERB
admet-394	99	11	the	the	DET
admet-394	99	12	oct-1	oct-1	ADV
admet-394	99	13	and	and	CCONJ
admet-394	99	14	oct-2	oct-2	NUM
admet-394	99	15	transporters	transporter	NOUN
admet-394	99	16	in	in	ADP
admet-394	99	17	c.	c.	PROPN
admet-394	99	18	elegans	elegans	PROPN
admet-394	99	19	.	.	PUNCT
admet-394	100	1	first	first	ADV
admet-394	100	2	,	,	PUNCT
admet-394	100	3	unlike	unlike	ADP
admet-394	100	4	the	the	DET
admet-394	100	5	oct-1	oct-1	ADV
admet-394	100	6	null	null	ADJ
admet-394	100	7	animals	animal	NOUN
admet-394	100	8	,	,	PUNCT
admet-394	100	9	downregulation	downregulation	NOUN
admet-394	100	10	of	of	ADP
admet-394	100	11	oct-2	oct-2	PRON
admet-394	100	12	did	do	AUX
admet-394	100	13	not	not	PART
admet-394	100	14	affect	affect	VERB
admet-394	100	15	the	the	DET
admet-394	100	16	lifespan	lifespan	NOUN
admet-394	100	17	of	of	ADP
admet-394	100	18	the	the	DET
admet-394	100	19	animals	animal	NOUN
admet-394	100	20	.	.	PUNCT
admet-394	101	1	second	second	ADJ
admet-394	101	2	,	,	PUNCT
admet-394	101	3	perhaps	perhaps	ADV
admet-394	101	4	most	most	ADV
admet-394	101	5	interesting	interesting	ADJ
admet-394	101	6	,	,	PUNCT
admet-394	101	7	the	the	DET
admet-394	101	8	depletion	depletion	NOUN
admet-394	101	9	of	of	ADP
admet-394	101	10	oct-2	oct-2	NUM
admet-394	101	11	rescued	rescue	VERB
admet-394	101	12	the	the	DET
admet-394	101	13	shortened	shorten	VERB
admet-394	101	14	lifespan	lifespan	NOUN
admet-394	101	15	of	of	ADP
admet-394	101	16	animals	animal	NOUN
admet-394	101	17	already	already	ADV
admet-394	101	18	deleted	delete	VERB
admet-394	101	19	for	for	ADP
admet-394	101	20	the	the	DET
admet-394	101	21	oct-1	oct-1	ADJ
admet-394	101	22	gene	gene	NOUN
admet-394	101	23	[	[	X
admet-394	101	24	33	33	NUM
admet-394	101	25	]	]	PUNCT
admet-394	101	26	.	.	PUNCT
admet-394	102	1	this	this	DET
admet-394	102	2	striking	striking	ADJ
admet-394	102	3	observation	observation	NOUN
admet-394	102	4	prompted	prompt	VERB
admet-394	102	5	the	the	DET
admet-394	102	6	possibility	possibility	NOUN
admet-394	102	7	that	that	SCONJ
admet-394	102	8	oct-1	oct-1	ADV
admet-394	102	9	might	might	AUX
admet-394	102	10	influence	influence	VERB
admet-394	102	11	oct-2	oct-2	DET
admet-394	102	12	function	function	NOUN
admet-394	102	13	,	,	PUNCT
admet-394	102	14	whereby	whereby	SCONJ
admet-394	102	15	oct-1	oct-1	DET
admet-394	102	16	downregulation	downregulation	NOUN
admet-394	102	17	leads	lead	VERB
admet-394	102	18	to	to	ADP
admet-394	102	19	oct-2	oct-2	NOUN
admet-394	102	20	upregulation	upregulation	NOUN
admet-394	102	21	.	.	PUNCT
admet-394	103	1	this	this	DET
admet-394	103	2	notion	notion	NOUN
admet-394	103	3	is	be	AUX
admet-394	103	4	based	base	VERB
admet-394	103	5	on	on	ADP
admet-394	103	6	the	the	DET
admet-394	103	7	fact	fact	NOUN
admet-394	103	8	that	that	SCONJ
admet-394	103	9	oct1	oct1	NOUN
admet-394	103	10	knockout	knockout	NOUN
admet-394	103	11	mice	mouse	NOUN
admet-394	103	12	manifest	manif	ADJ
admet-394	103	13	upregulation	upregulation	NOUN
admet-394	103	14	of	of	ADP
admet-394	103	15	two	two	NUM
admet-394	103	16	related	relate	VERB
admet-394	103	17	transporter	transporter	NOUN
admet-394	103	18	genes	gene	NOUN
admet-394	103	19	,	,	PUNCT
admet-394	103	20	oct2	oct2	NOUN
admet-394	103	21	and	and	CCONJ
admet-394	103	22	oct3	oct3	PROPN
admet-394	104	1	[	[	X
admet-394	104	2	34	34	NUM
admet-394	104	3	]	]	PUNCT
admet-394	104	4	.	.	PUNCT
admet-394	105	1	and	and	CCONJ
admet-394	105	2	third	third	ADJ
admet-394	105	3	,	,	PUNCT
admet-394	105	4	quantitative	quantitative	ADJ
admet-394	105	5	pcr	pcr	ADJ
admet-394	105	6	analysis	analysis	NOUN
admet-394	105	7	indeed	indeed	ADV
admet-394	105	8	revealed	reveal	VERB
admet-394	105	9	that	that	SCONJ
admet-394	105	10	downregulation	downregulation	NOUN
admet-394	105	11	of	of	ADP
admet-394	105	12	oct-1	oct-1	ADV
admet-394	105	13	led	lead	VERB
admet-394	105	14	to	to	ADP
admet-394	105	15	the	the	DET
admet-394	105	16	upregulation	upregulation	NOUN
admet-394	105	17	of	of	ADP
admet-394	105	18	oct-2	oct-2	NUM
admet-394	105	19	expression	expression	NOUN
admet-394	105	20	in	in	ADP
admet-394	105	21	several	several	ADJ
admet-394	105	22	tissues	tissue	NOUN
admet-394	105	23	of	of	ADP
admet-394	105	24	the	the	DET
admet-394	105	25	animals	animal	NOUN
admet-394	105	26	,	,	PUNCT
admet-394	105	27	while	while	SCONJ
admet-394	105	28	several	several	ADJ
admet-394	105	29	control	control	NOUN
admet-394	105	30	genes	gene	NOUN
admet-394	105	31	,	,	PUNCT
admet-394	105	32	such	such	ADJ
admet-394	105	33	as	as	ADP
admet-394	105	34	act-1	act-1	PUNCT
admet-394	105	35	encoding	encode	VERB
admet-394	105	36	actin	actin	NOUN
admet-394	105	37	,	,	PUNCT
admet-394	105	38	were	be	AUX
admet-394	105	39	unaffected	unaffected	ADJ
admet-394	105	40	[	[	X
admet-394	105	41	33	33	NUM
admet-394	105	42	]	]	PUNCT
admet-394	105	43	.	.	PUNCT
admet-394	106	1	as	as	ADP
admet-394	106	2	such	such	ADJ
admet-394	106	3	,	,	PUNCT
admet-394	106	4	we	we	PRON
admet-394	106	5	proposed	propose	VERB
admet-394	106	6	that	that	SCONJ
admet-394	106	7	oct-2	oct-2	NUM
admet-394	106	8	upregulation	upregulation	NOUN
admet-394	106	9	could	could	AUX
admet-394	106	10	be	be	AUX
admet-394	106	11	responsible	responsible	ADJ
admet-394	106	12	for	for	ADP
admet-394	106	13	triggering	trigger	VERB
admet-394	106	14	uptake	uptake	NOUN
admet-394	106	15	of	of	ADP
admet-394	106	16	toxic	toxic	ADJ
admet-394	106	17	environmental	environmental	ADJ
admet-394	106	18	compounds	compound	NOUN
admet-394	106	19	into	into	ADP
admet-394	106	20	the	the	DET
admet-394	106	21	animals	animal	NOUN
admet-394	106	22	and	and	CCONJ
admet-394	106	23	thus	thus	ADV
admet-394	106	24	account	account	VERB
admet-394	106	25	for	for	ADP
admet-394	106	26	the	the	DET
admet-394	106	27	shortened	shorten	VERB
admet-394	106	28	lifespan	lifespan	NOUN
admet-394	106	29	displayed	display	VERB
admet-394	106	30	by	by	ADP
admet-394	106	31	the	the	DET
admet-394	106	32	oct-1	oct-1	ADJ
admet-394	106	33	animals	animal	NOUN
admet-394	106	34	.	.	PUNCT
admet-394	107	1	there	there	PRON
admet-394	107	2	is	be	VERB
admet-394	107	3	evidence	evidence	NOUN
admet-394	107	4	to	to	PART
admet-394	107	5	support	support	VERB
admet-394	107	6	that	that	SCONJ
admet-394	107	7	the	the	DET
admet-394	107	8	upregulation	upregulation	NOUN
admet-394	107	9	of	of	ADP
admet-394	107	10	oct-2	oct-2	NUM
admet-394	107	11	leads	lead	NOUN
admet-394	107	12	to	to	ADP
admet-394	107	13	the	the	DET
admet-394	107	14	import	import	NOUN
admet-394	107	15	of	of	ADP
admet-394	107	16	toxic	toxic	ADJ
admet-394	107	17	compounds	compound	NOUN
admet-394	107	18	from	from	ADP
admet-394	107	19	the	the	DET
admet-394	107	20	environment	environment	NOUN
admet-394	107	21	into	into	ADP
admet-394	107	22	the	the	DET
admet-394	107	23	animals	animal	NOUN
admet-394	107	24	.	.	PUNCT
admet-394	108	1	this	this	PRON
admet-394	108	2	was	be	AUX
admet-394	108	3	documented	document	VERB
admet-394	108	4	using	use	VERB
admet-394	108	5	a	a	DET
admet-394	108	6	simple	simple	ADJ
admet-394	108	7	reporter	reporter	NOUN
admet-394	108	8	animal	animal	NOUN
admet-394	108	9	that	that	PRON
admet-394	108	10	harbours	harbour	VERB
admet-394	108	11	within	within	ADP
admet-394	108	12	its	its	PRON
admet-394	108	13	genome	genome	NOUN
admet-394	108	14	the	the	DET
admet-394	108	15	oxidative	oxidative	ADJ
admet-394	108	16	stress	stress	NOUN
admet-394	108	17	response	response	NOUN
admet-394	108	18	gene	gene	NOUN
admet-394	108	19	gst-4	gst-4	PUNCT
admet-394	108	20	encoding	encode	VERB
admet-394	108	21	glutathione	glutathione	NOUN
admet-394	108	22	s	s	NOUN
admet-394	108	23	-	-	NOUN
admet-394	108	24	transferase	transferase	NOUN
admet-394	108	25	4	4	NUM
admet-394	108	26	fused	fuse	VERB
admet-394	108	27	to	to	ADP
admet-394	108	28	the	the	DET
admet-394	108	29	green	green	ADJ
admet-394	108	30	fluorescent	fluorescent	NOUN
admet-394	108	31	protein	protein	NOUN
admet-394	108	32	(	(	PUNCT
admet-394	108	33	gfp	gfp	PROPN
admet-394	108	34	)	)	PUNCT
admet-394	109	1	[	[	X
admet-394	109	2	35	35	NUM
admet-394	109	3	,	,	PUNCT
admet-394	109	4	36	36	NUM
admet-394	109	5	]	]	PUNCT
admet-394	109	6	.	.	PUNCT
admet-394	110	1	in	in	ADP
admet-394	110	2	c.	c.	PROPN
admet-394	110	3	elegans	elegan	NOUN
admet-394	110	4	skn-1	skn-1	ADV
admet-394	110	5	,	,	PUNCT
admet-394	110	6	the	the	DET
admet-394	110	7	counterpart	counterpart	NOUN
admet-394	110	8	of	of	ADP
admet-394	110	9	the	the	DET
admet-394	110	10	mammalian	mammalian	ADJ
admet-394	110	11	nrf2	nrf2	NOUN
admet-394	110	12	,	,	PUNCT
admet-394	110	13	senses	sense	NOUN
admet-394	110	14	oxidative	oxidative	VERB
admet-394	110	15	stress	stress	NOUN
admet-394	110	16	and	and	CCONJ
admet-394	110	17	turn	turn	VERB
admet-394	110	18	on	on	ADP
admet-394	110	19	the	the	DET
admet-394	110	20	expression	expression	NOUN
admet-394	110	21	of	of	ADP
admet-394	110	22	gst-4	gst-4	NOUN
admet-394	110	23	.	.	PUNCT
admet-394	111	1	we	we	PRON
admet-394	111	2	used	use	VERB
admet-394	111	3	the	the	DET
admet-394	111	4	gst::gfp	gst::gfp	PROPN
admet-394	111	5	reporter	reporter	NOUN
admet-394	111	6	animals	animal	NOUN
admet-394	111	7	to	to	PART
admet-394	111	8	monitor	monitor	VERB
admet-394	111	9	oxidative	oxidative	ADJ
admet-394	111	10	stress	stress	NOUN
admet-394	111	11	caused	cause	VERB
admet-394	111	12	by	by	ADP
admet-394	111	13	toxic	toxic	ADJ
admet-394	111	14	compounds	compound	NOUN
admet-394	111	15	and	and	CCONJ
admet-394	111	16	showed	show	VERB
admet-394	111	17	that	that	SCONJ
admet-394	111	18	these	these	DET
admet-394	111	19	animals	animal	NOUN
admet-394	111	20	expressed	express	VERB
admet-394	111	21	a	a	DET
admet-394	111	22	basal	basal	ADJ
admet-394	111	23	level	level	NOUN
admet-394	111	24	of	of	ADP
admet-394	111	25	gst-4::gfp	gst-4::gfp	NOUN
admet-394	111	26	in	in	ADP
admet-394	111	27	the	the	DET
admet-394	111	28	intestine	intestine	NOUN
admet-394	111	29	.	.	PUNCT
admet-394	112	1	however	however	ADV
admet-394	112	2	,	,	PUNCT
admet-394	112	3	the	the	DET
admet-394	112	4	expression	expression	NOUN
admet-394	112	5	level	level	NOUN
admet-394	112	6	of	of	ADP
admet-394	112	7	the	the	DET
admet-394	112	8	gst-4::gfp	gst-4::gfp	NOUN
admet-394	112	9	was	be	AUX
admet-394	112	10	greatly	greatly	ADV
admet-394	112	11	stimulated	stimulate	VERB
admet-394	112	12	following	follow	VERB
admet-394	112	13	rnai	rnai	NOUN
admet-394	112	14	downregulation	downregulation	NOUN
admet-394	112	15	of	of	ADP
admet-394	112	16	oct-1	oct-1	PRON
admet-394	112	17	that	that	PRON
admet-394	112	18	led	lead	VERB
admet-394	112	19	to	to	ADP
admet-394	112	20	the	the	DET
admet-394	112	21	upregulation	upregulation	NOUN
admet-394	112	22	of	of	ADP
admet-394	112	23	oct-2	oct-2	NOUN
admet-394	112	24	[	[	X
admet-394	112	25	33	33	NUM
admet-394	112	26	]	]	PUNCT
admet-394	112	27	.	.	PUNCT
admet-394	113	1	consistent	consistent	ADJ
admet-394	113	2	with	with	ADP
admet-394	113	3	this	this	DET
admet-394	113	4	observation	observation	NOUN
admet-394	113	5	,	,	PUNCT
admet-394	113	6	downregulation	downregulation	NOUN
admet-394	113	7	of	of	ADP
admet-394	113	8	the	the	DET
admet-394	113	9	oct-2	oct-2	NUM
admet-394	113	10	transporter	transporter	NOUN
admet-394	113	11	gene	gene	NOUN
admet-394	113	12	by	by	ADP
admet-394	113	13	rnai	rnai	PROPN
admet-394	113	14	lowered	lower	VERB
admet-394	113	15	the	the	DET
admet-394	113	16	basal	basal	ADJ
admet-394	113	17	levels	level	NOUN
admet-394	113	18	of	of	ADP
admet-394	113	19	gst-4::gfp	gst-4::gfp	NOUN
admet-394	113	20	expression	expression	NOUN
admet-394	113	21	in	in	ADP
admet-394	113	22	the	the	DET
admet-394	113	23	reporter	reporter	NOUN
admet-394	113	24	strain	strain	VERB
admet-394	114	1	[	[	X
admet-394	114	2	33	33	NUM
admet-394	114	3	]	]	PUNCT
admet-394	114	4	.	.	PUNCT
admet-394	115	1	thus	thus	ADV
admet-394	115	2	,	,	PUNCT
admet-394	115	3	oct-2	oct-2	NUM
admet-394	115	4	upregulation	upregulation	NOUN
admet-394	115	5	,	,	PUNCT
admet-394	115	6	via	via	ADP
admet-394	115	7	oct-1	oct-1	ADJ
admet-394	115	8	downregulation	downregulation	NOUN
admet-394	115	9	,	,	PUNCT
admet-394	115	10	allows	allow	VERB
admet-394	115	11	entry	entry	NOUN
admet-394	115	12	of	of	ADP
admet-394	115	13	toxic	toxic	ADJ
admet-394	115	14	compounds	compound	NOUN
admet-394	115	15	such	such	ADJ
admet-394	115	16	as	as	ADP
admet-394	115	17	prooxidants	prooxidant	NOUN
admet-394	115	18	into	into	ADP
admet-394	115	19	c.	c.	PROPN
admet-394	115	20	elegans	elegans	PROPN
admet-394	115	21	.	.	PUNCT
admet-394	116	1	these	these	DET
admet-394	116	2	prooxidants	prooxidant	NOUN
admet-394	116	3	increased	increase	VERB
admet-394	116	4	the	the	DET
admet-394	116	5	oxidative	oxidative	ADJ
admet-394	116	6	stress	stress	NOUN
admet-394	116	7	of	of	ADP
admet-394	116	8	the	the	DET
admet-394	116	9	animals	animal	NOUN
admet-394	116	10	that	that	PRON
admet-394	116	11	could	could	AUX
admet-394	116	12	cause	cause	VERB
admet-394	116	13	oxidative	oxidative	ADJ
admet-394	116	14	damages	damage	NOUN
admet-394	116	15	to	to	ADP
admet-394	116	16	various	various	ADJ
admet-394	116	17	macromolecules	macromolecule	NOUN
admet-394	116	18	,	,	PUNCT
admet-394	116	19	such	such	ADJ
admet-394	116	20	as	as	ADP
admet-394	116	21	dna	dna	NOUN
admet-394	116	22	,	,	PUNCT
admet-394	116	23	and	and	CCONJ
admet-394	116	24	leading	lead	VERB
admet-394	116	25	to	to	ADP
admet-394	116	26	the	the	DET
admet-394	116	27	shortened	shorten	VERB
admet-394	116	28	lifespan	lifespan	NOUN
admet-394	116	29	of	of	ADP
admet-394	116	30	the	the	DET
admet-394	116	31	oct-1	oct-1	ADV
admet-394	116	32	null	null	ADJ
admet-394	116	33	animals	animal	NOUN
admet-394	116	34	.	.	PUNCT
admet-394	117	1	admet	admet	PROPN
admet-394	117	2	&	&	CCONJ
admet-394	117	3	dmpk	dmpk	PROPN
admet-394	117	4	5(3	5(3	NUM
admet-394	117	5	)	)	PUNCT
admet-394	117	6	(	(	PUNCT
admet-394	117	7	2017	2017	NUM
admet-394	117	8	)	)	PUNCT
admet-394	117	9	146	146	NUM
admet-394	117	10	-	-	SYM
admet-394	117	11	158	158	NUM
admet-394	117	12	oct-1	oct-1	NUM
admet-394	117	13	and	and	CCONJ
admet-394	117	14	oct-2	oct-2	NUM
admet-394	117	15	in	in	ADP
admet-394	117	16	caenorhabditis	caenorhabditis	PROPN
admet-394	117	17	elegans	elegan	NOUN
admet-394	117	18	doi	doi	NOUN
admet-394	117	19	:	:	PUNCT
admet-394	117	20	10.5599	10.5599	NUM
admet-394	117	21	/	/	SYM
admet-394	117	22	admet.5.3.394	admet.5.3.394	PRON
admet-394	117	23	151	151	NUM
admet-394	117	24	oct-2	oct-2	NUM
admet-394	117	25	mediates	mediate	NOUN
admet-394	117	26	the	the	DET
admet-394	117	27	accumulation	accumulation	NOUN
admet-394	117	28	of	of	ADP
admet-394	117	29	doxorubicin	doxorubicin	PROPN
admet-394	117	30	in	in	ADP
admet-394	117	31	c.	c.	PROPN
admet-394	117	32	elegans	elegans	PROPN
admet-394	117	33	tissues	tissue	NOUN
admet-394	117	34	equipped	equip	VERB
admet-394	117	35	with	with	ADP
admet-394	117	36	the	the	DET
admet-394	117	37	new	new	ADJ
admet-394	117	38	knowledge	knowledge	NOUN
admet-394	117	39	on	on	ADP
admet-394	117	40	the	the	DET
admet-394	117	41	regulation	regulation	NOUN
admet-394	117	42	of	of	ADP
admet-394	117	43	oct-2	oct-2	NUM
admet-394	117	44	by	by	ADP
admet-394	117	45	oct-1	oct-1	PRON
admet-394	118	1	,	,	PUNCT
admet-394	118	2	we	we	PRON
admet-394	118	3	checked	check	VERB
admet-394	118	4	if	if	SCONJ
admet-394	118	5	these	these	DET
admet-394	118	6	transporters	transporter	NOUN
admet-394	118	7	possess	possess	VERB
admet-394	118	8	the	the	DET
admet-394	118	9	ability	ability	NOUN
admet-394	118	10	to	to	PART
admet-394	118	11	drive	drive	VERB
admet-394	118	12	doxorubicin	doxorubicin	PROPN
admet-394	118	13	uptake	uptake	NOUN
admet-394	118	14	and	and	CCONJ
admet-394	118	15	accumulation	accumulation	NOUN
admet-394	118	16	into	into	ADP
admet-394	118	17	c.	c.	PROPN
admet-394	118	18	elegans	elegan	NOUN
admet-394	118	19	tissues	tissue	NOUN
admet-394	118	20	.	.	PUNCT
admet-394	119	1	in	in	ADP
admet-394	119	2	the	the	DET
admet-394	119	3	design	design	NOUN
admet-394	119	4	of	of	ADP
admet-394	119	5	the	the	DET
admet-394	119	6	experiment	experiment	NOUN
admet-394	119	7	,	,	PUNCT
admet-394	119	8	the	the	DET
admet-394	119	9	fluorescent	fluorescent	ADJ
admet-394	119	10	property	property	NOUN
admet-394	119	11	of	of	ADP
admet-394	119	12	doxorubicin	doxorubicin	PROPN
admet-394	119	13	,	,	PUNCT
admet-394	119	14	emitting	emit	VERB
admet-394	119	15	fluorescence	fluorescence	NOUN
admet-394	119	16	at	at	ADP
admet-394	119	17	wavelengths	wavelength	NOUN
admet-394	119	18	of	of	ADP
admet-394	119	19	λ	λ	PROPN
admet-394	119	20	ex	ex	X
admet-394	119	21	470	470	NUM
admet-394	119	22	nm	nm	NOUN
admet-394	119	23	λ	λ	X
admet-394	119	24	em	em	PRON
admet-394	119	25	585	585	NUM
admet-394	119	26	nm	nm	NOUN
admet-394	119	27	,	,	PUNCT
admet-394	119	28	became	become	VERB
admet-394	119	29	a	a	DET
admet-394	119	30	convenient	convenient	ADJ
admet-394	119	31	means	mean	NOUN
admet-394	119	32	to	to	PART
admet-394	119	33	monitor	monitor	VERB
admet-394	119	34	its	its	PRON
admet-394	119	35	uptake	uptake	NOUN
admet-394	119	36	in	in	ADP
admet-394	119	37	situ	situ	NOUN
admet-394	119	38	by	by	ADP
admet-394	119	39	imaging	image	VERB
admet-394	119	40	the	the	DET
admet-394	119	41	pharynx	pharynx	NOUN
admet-394	119	42	,	,	PUNCT
admet-394	119	43	a	a	DET
admet-394	119	44	very	very	ADV
admet-394	119	45	large	large	ADJ
admet-394	119	46	and	and	CCONJ
admet-394	119	47	visible	visible	ADJ
admet-394	119	48	organ	organ	NOUN
admet-394	119	49	.	.	PUNCT
admet-394	120	1	on	on	ADP
admet-394	120	2	the	the	DET
admet-394	120	3	basis	basis	NOUN
admet-394	120	4	of	of	ADP
admet-394	120	5	the	the	DET
admet-394	120	6	previous	previous	ADJ
admet-394	120	7	studies	study	NOUN
admet-394	120	8	in	in	ADP
admet-394	120	9	both	both	CCONJ
admet-394	120	10	human	human	ADJ
admet-394	120	11	and	and	CCONJ
admet-394	120	12	yeast	yeast	NOUN
admet-394	120	13	cells	cell	NOUN
admet-394	120	14	,	,	PUNCT
admet-394	120	15	we	we	PRON
admet-394	120	16	anticipated	anticipate	VERB
admet-394	120	17	that	that	SCONJ
admet-394	120	18	c.	c.	PROPN
admet-394	120	19	elegans	elegan	NOUN
admet-394	120	20	oct-1	oct-1	NUM
admet-394	120	21	would	would	AUX
admet-394	120	22	act	act	VERB
admet-394	120	23	as	as	ADP
admet-394	120	24	an	an	DET
admet-394	120	25	uptake	uptake	ADJ
admet-394	120	26	transporter	transporter	NOUN
admet-394	120	27	and	and	CCONJ
admet-394	120	28	that	that	SCONJ
admet-394	120	29	oct-1	oct-1	ADJ
admet-394	120	30	null	null	ADJ
admet-394	120	31	animals	animal	NOUN
admet-394	120	32	would	would	AUX
admet-394	120	33	display	display	VERB
admet-394	120	34	very	very	ADV
admet-394	120	35	little	little	ADJ
admet-394	120	36	doxorubicin	doxorubicin	NOUN
admet-394	120	37	uptake	uptake	ADJ
admet-394	120	38	[	[	X
admet-394	120	39	18	18	NUM
admet-394	120	40	,	,	PUNCT
admet-394	120	41	19	19	NUM
admet-394	120	42	]	]	PUNCT
admet-394	120	43	.	.	PUNCT
admet-394	121	1	unexpectedly	unexpectedly	ADV
admet-394	121	2	,	,	PUNCT
admet-394	121	3	we	we	PRON
admet-394	121	4	observed	observe	VERB
admet-394	121	5	that	that	SCONJ
admet-394	121	6	the	the	DET
admet-394	121	7	c.	c.	PROPN
admet-394	121	8	elegans	elegan	NOUN
admet-394	121	9	oct-1	oct-1	PART
admet-394	121	10	null	null	ADJ
admet-394	121	11	mutant	mutant	NOUN
admet-394	121	12	exposed	expose	VERB
admet-394	121	13	to	to	ADP
admet-394	121	14	doxorubicin	doxorubicin	PROPN
admet-394	121	15	depicted	depict	VERB
admet-394	121	16	a	a	DET
admet-394	121	17	markedly	markedly	ADV
admet-394	121	18	stimulated	stimulate	VERB
admet-394	121	19	fluorescence	fluorescence	NOUN
admet-394	121	20	intensity	intensity	NOUN
admet-394	121	21	of	of	ADP
admet-394	121	22	the	the	DET
admet-394	121	23	drug	drug	NOUN
admet-394	121	24	in	in	ADP
admet-394	121	25	the	the	DET
admet-394	121	26	pharynx	pharynx	NOUN
admet-394	121	27	,	,	PUNCT
admet-394	121	28	as	as	SCONJ
admet-394	121	29	compared	compare	VERB
admet-394	121	30	to	to	ADP
admet-394	121	31	the	the	DET
admet-394	121	32	parent	parent	NOUN
admet-394	121	33	animals	animal	NOUN
admet-394	121	34	[	[	X
admet-394	121	35	33	33	NUM
admet-394	121	36	]	]	PUNCT
admet-394	121	37	.	.	PUNCT
admet-394	122	1	the	the	DET
admet-394	122	2	simplest	simple	ADJ
admet-394	122	3	explanation	explanation	NOUN
admet-394	122	4	for	for	ADP
admet-394	122	5	this	this	DET
admet-394	122	6	finding	finding	NOUN
admet-394	122	7	is	be	AUX
admet-394	122	8	that	that	DET
admet-394	122	9	deletion	deletion	NOUN
admet-394	122	10	of	of	ADP
admet-394	122	11	the	the	DET
admet-394	122	12	oct-1	oct-1	PUNCT
admet-394	122	13	gene	gene	NOUN
admet-394	122	14	resulted	result	VERB
admet-394	122	15	in	in	ADP
admet-394	122	16	the	the	DET
admet-394	122	17	upregulation	upregulation	NOUN
admet-394	122	18	of	of	ADP
admet-394	122	19	oct-2	oct-2	NOUN
admet-394	122	20	,	,	PUNCT
admet-394	122	21	and	and	CCONJ
admet-394	122	22	it	it	PRON
admet-394	122	23	is	be	AUX
admet-394	122	24	oct-2	oct-2	NOUN
admet-394	122	25	that	that	PRON
admet-394	122	26	is	be	AUX
admet-394	122	27	responsible	responsible	ADJ
admet-394	122	28	for	for	ADP
admet-394	122	29	doxorubicin	doxorubicin	PROPN
admet-394	122	30	uptake	uptake	NOUN
admet-394	122	31	.	.	PUNCT
admet-394	123	1	indeed	indeed	ADV
admet-394	123	2	,	,	PUNCT
admet-394	123	3	the	the	DET
admet-394	123	4	downregulation	downregulation	NOUN
admet-394	123	5	of	of	ADP
admet-394	123	6	oct-2	oct-2	NUM
admet-394	123	7	via	via	ADP
admet-394	123	8	rnai	rnai	PROPN
admet-394	123	9	feeding	feeding	NOUN
admet-394	123	10	bacteria	bacteria	NOUN
admet-394	123	11	of	of	ADP
admet-394	123	12	the	the	DET
admet-394	123	13	oct-1	oct-1	ADV
admet-394	123	14	null	null	ADJ
admet-394	123	15	mutant	mutant	NOUN
admet-394	123	16	completely	completely	ADV
admet-394	123	17	blocked	block	VERB
admet-394	123	18	the	the	DET
admet-394	123	19	uptake	uptake	NOUN
admet-394	123	20	of	of	ADP
admet-394	123	21	doxorubicin	doxorubicin	PROPN
admet-394	123	22	,	,	PUNCT
admet-394	123	23	clearly	clearly	ADV
admet-394	123	24	indicating	indicate	VERB
admet-394	123	25	that	that	SCONJ
admet-394	123	26	oct-2	oct-2	PROPN
admet-394	123	27	and	and	CCONJ
admet-394	123	28	not	not	PART
admet-394	123	29	oct-1	oct-1	ADV
admet-394	123	30	has	have	VERB
admet-394	123	31	a	a	DET
admet-394	123	32	predominant	predominant	ADJ
admet-394	123	33	role	role	NOUN
admet-394	123	34	in	in	ADP
admet-394	123	35	the	the	DET
admet-394	123	36	drug	drug	NOUN
admet-394	123	37	uptake	uptake	ADJ
admet-394	123	38	[	[	X
admet-394	123	39	33	33	NUM
admet-394	123	40	]	]	PUNCT
admet-394	123	41	.	.	PUNCT
admet-394	124	1	these	these	DET
admet-394	124	2	observations	observation	NOUN
admet-394	124	3	in	in	ADP
admet-394	124	4	c.	c.	PROPN
admet-394	124	5	elegans	elegan	NOUN
admet-394	124	6	contradict	contradict	VERB
admet-394	124	7	the	the	DET
admet-394	124	8	previously	previously	ADV
admet-394	124	9	reported	report	VERB
admet-394	124	10	role	role	NOUN
admet-394	124	11	for	for	ADP
admet-394	124	12	oct-1	oct-1	PRON
admet-394	124	13	as	as	ADP
admet-394	124	14	an	an	DET
admet-394	124	15	uptake	uptake	ADJ
admet-394	124	16	transporter	transporter	NOUN
admet-394	124	17	[	[	X
admet-394	124	18	18	18	NUM
admet-394	124	19	,	,	PUNCT
admet-394	124	20	31	31	NUM
admet-394	124	21	]	]	PUNCT
admet-394	124	22	.	.	PUNCT
admet-394	125	1	it	it	PRON
admet-394	125	2	is	be	AUX
admet-394	125	3	possible	possible	ADJ
admet-394	125	4	that	that	SCONJ
admet-394	125	5	in	in	ADP
admet-394	125	6	the	the	DET
admet-394	125	7	natural	natural	ADJ
admet-394	125	8	environment	environment	NOUN
admet-394	125	9	oct-1	oct-1	PUNCT
admet-394	125	10	may	may	AUX
admet-394	125	11	be	be	AUX
admet-394	125	12	modified	modify	VERB
admet-394	125	13	to	to	PART
admet-394	125	14	exert	exert	VERB
admet-394	125	15	a	a	DET
admet-394	125	16	distinct	distinct	ADJ
admet-394	125	17	role	role	NOUN
admet-394	125	18	other	other	ADJ
admet-394	125	19	than	than	ADP
admet-394	125	20	functioning	function	VERB
admet-394	125	21	as	as	ADP
admet-394	125	22	an	an	DET
admet-394	125	23	uptake	uptake	ADJ
admet-394	125	24	transporter	transporter	NOUN
admet-394	125	25	or	or	CCONJ
admet-394	125	26	alternatively	alternatively	ADV
admet-394	125	27	exhibits	exhibit	VERB
admet-394	125	28	specificity	specificity	NOUN
admet-394	125	29	for	for	ADP
admet-394	125	30	an	an	DET
admet-394	125	31	entirely	entirely	ADV
admet-394	125	32	different	different	ADJ
admet-394	125	33	class	class	NOUN
admet-394	125	34	of	of	ADP
admet-394	125	35	substrates	substrate	NOUN
admet-394	125	36	.	.	PUNCT
admet-394	126	1	based	base	VERB
admet-394	126	2	on	on	ADP
admet-394	126	3	the	the	DET
admet-394	126	4	present	present	ADJ
admet-394	126	5	evidence	evidence	NOUN
admet-394	126	6	,	,	PUNCT
admet-394	126	7	we	we	PRON
admet-394	126	8	believe	believe	VERB
admet-394	126	9	that	that	SCONJ
admet-394	126	10	oct-2	oct-2	PRON
admet-394	126	11	might	might	AUX
admet-394	126	12	be	be	AUX
admet-394	126	13	the	the	DET
admet-394	126	14	key	key	ADJ
admet-394	126	15	transporter	transporter	NOUN
admet-394	126	16	that	that	PRON
admet-394	126	17	mediates	mediate	VERB
admet-394	126	18	doxorubicin	doxorubicin	NOUN
admet-394	126	19	uptake	uptake	ADJ
admet-394	126	20	into	into	ADP
admet-394	126	21	c.	c.	PROPN
admet-394	126	22	elegans	elegans	PROPN
admet-394	126	23	.	.	PUNCT
admet-394	127	1	oct2	oct2	PROPN
admet-394	127	2	also	also	ADV
admet-394	127	3	has	have	VERB
admet-394	127	4	the	the	DET
admet-394	127	5	ability	ability	NOUN
admet-394	127	6	to	to	PART
admet-394	127	7	recognize	recognize	VERB
admet-394	127	8	and	and	CCONJ
admet-394	127	9	transport	transport	VERB
admet-394	127	10	other	other	ADJ
admet-394	127	11	cationic	cationic	ADJ
admet-394	127	12	compounds	compound	NOUN
admet-394	127	13	.	.	PUNCT
admet-394	128	1	for	for	ADP
admet-394	128	2	example	example	NOUN
admet-394	128	3	,	,	PUNCT
admet-394	128	4	choline	choline	NOUN
admet-394	128	5	can	can	AUX
admet-394	128	6	compete	compete	VERB
admet-394	128	7	for	for	ADP
admet-394	128	8	the	the	DET
admet-394	128	9	uptake	uptake	NOUN
admet-394	128	10	of	of	ADP
admet-394	128	11	doxorubicin	doxorubicin	PROPN
admet-394	128	12	entry	entry	NOUN
admet-394	128	13	into	into	ADP
admet-394	128	14	c.	c.	PROPN
admet-394	128	15	elegans	elegan	NOUN
admet-394	128	16	,	,	PUNCT
admet-394	128	17	suggesting	suggest	VERB
admet-394	128	18	that	that	SCONJ
admet-394	128	19	it	it	PRON
admet-394	128	20	is	be	AUX
admet-394	128	21	likely	likely	ADJ
admet-394	128	22	a	a	DET
admet-394	128	23	substrate	substrate	NOUN
admet-394	128	24	for	for	ADP
admet-394	128	25	oct2	oct2	NOUN
admet-394	128	26	[	[	X
admet-394	128	27	33	33	NUM
admet-394	128	28	,	,	PUNCT
admet-394	128	29	37	37	NUM
admet-394	128	30	]	]	PUNCT
admet-394	128	31	.	.	PUNCT
admet-394	129	1	in	in	ADP
admet-394	129	2	fact	fact	NOUN
admet-394	129	3	,	,	PUNCT
admet-394	129	4	choline	choline	NOUN
admet-394	129	5	is	be	AUX
admet-394	129	6	a	a	DET
admet-394	129	7	substrate	substrate	NOUN
admet-394	129	8	for	for	ADP
admet-394	129	9	human	human	ADJ
admet-394	129	10	oct1	oct1	NOUN
admet-394	129	11	and	and	CCONJ
admet-394	129	12	it	it	PRON
admet-394	129	13	impedes	impede	VERB
admet-394	129	14	the	the	DET
admet-394	129	15	uptake	uptake	NOUN
admet-394	129	16	of	of	ADP
admet-394	129	17	daunorubicin	daunorubicin	NOUN
admet-394	129	18	into	into	ADP
admet-394	129	19	human	human	ADJ
admet-394	129	20	cell	cell	NOUN
admet-394	129	21	lines	line	NOUN
admet-394	129	22	[	[	X
admet-394	129	23	19	19	NUM
admet-394	129	24	]	]	PUNCT
admet-394	129	25	.	.	PUNCT
admet-394	130	1	it	it	PRON
admet-394	130	2	is	be	AUX
admet-394	130	3	reasonable	reasonable	ADJ
admet-394	130	4	to	to	PART
admet-394	130	5	propose	propose	VERB
admet-394	130	6	that	that	SCONJ
admet-394	130	7	any	any	DET
admet-394	130	8	compound	compound	NOUN
admet-394	130	9	that	that	PRON
admet-394	130	10	competes	compete	VERB
admet-394	130	11	for	for	ADP
admet-394	130	12	doxorubicin	doxorubicin	PROPN
admet-394	130	13	uptake	uptake	VERB
admet-394	130	14	into	into	ADP
admet-394	130	15	the	the	DET
admet-394	130	16	c.	c.	NOUN
admet-394	130	17	elegans	elegan	NOUN
admet-394	130	18	oct-1	oct-1	ADV
admet-394	130	19	null	null	ADJ
admet-394	130	20	animals	animal	NOUN
admet-394	130	21	is	be	AUX
admet-394	130	22	likely	likely	ADJ
admet-394	130	23	a	a	DET
admet-394	130	24	putative	putative	ADJ
admet-394	130	25	substrate	substrate	NOUN
admet-394	130	26	for	for	ADP
admet-394	130	27	oct-2	oct-2	NOUN
admet-394	130	28	,	,	PUNCT
admet-394	130	29	thus	thus	ADV
admet-394	130	30	providing	provide	VERB
admet-394	130	31	a	a	DET
admet-394	130	32	foundation	foundation	NOUN
admet-394	130	33	to	to	PART
admet-394	130	34	develop	develop	VERB
admet-394	130	35	a	a	DET
admet-394	130	36	screening	screening	NOUN
admet-394	130	37	tool	tool	NOUN
admet-394	130	38	to	to	PART
admet-394	130	39	find	find	VERB
admet-394	130	40	therapeutic	therapeutic	ADJ
admet-394	130	41	compounds	compound	NOUN
admet-394	130	42	that	that	PRON
admet-394	130	43	are	be	AUX
admet-394	130	44	transported	transport	VERB
admet-394	130	45	by	by	ADP
admet-394	130	46	oct-2	oct-2	NOUN
admet-394	130	47	.	.	PUNCT
admet-394	131	1	in	in	ADP
admet-394	131	2	developing	develop	VERB
admet-394	131	3	this	this	DET
admet-394	131	4	assay	assay	NOUN
admet-394	131	5	further	far	ADV
admet-394	131	6	,	,	PUNCT
admet-394	131	7	it	it	PRON
admet-394	131	8	is	be	AUX
admet-394	131	9	noteworthy	noteworthy	ADJ
admet-394	131	10	that	that	SCONJ
admet-394	131	11	other	other	ADJ
admet-394	131	12	factors	factor	NOUN
admet-394	131	13	should	should	AUX
admet-394	131	14	be	be	AUX
admet-394	131	15	considered	consider	VERB
admet-394	131	16	such	such	ADJ
admet-394	131	17	as	as	ADP
admet-394	131	18	compounds	compound	NOUN
admet-394	131	19	,	,	PUNCT
admet-394	131	20	e.g.	e.g.	ADV
admet-394	131	21	,	,	PUNCT
admet-394	131	22	spermine	spermine	NOUN
admet-394	131	23	that	that	PRON
admet-394	131	24	could	could	AUX
admet-394	131	25	quench	quench	VERB
admet-394	131	26	the	the	DET
admet-394	131	27	fluorescence	fluorescence	NOUN
admet-394	131	28	of	of	ADP
admet-394	131	29	doxorubicin	doxorubicin	PROPN
admet-394	131	30	leading	lead	VERB
admet-394	131	31	to	to	ADP
admet-394	131	32	false	false	ADJ
admet-394	131	33	positives	positive	NOUN
admet-394	131	34	.	.	PUNCT
admet-394	132	1	nonetheless	nonetheless	ADV
admet-394	132	2	,	,	PUNCT
admet-394	132	3	the	the	DET
admet-394	132	4	same	same	ADJ
admet-394	132	5	assay	assay	NOUN
admet-394	132	6	can	can	AUX
admet-394	132	7	be	be	AUX
admet-394	132	8	extended	extend	VERB
admet-394	132	9	to	to	PART
admet-394	132	10	find	find	VERB
admet-394	132	11	compounds	compound	NOUN
admet-394	132	12	that	that	PRON
admet-394	132	13	could	could	AUX
admet-394	132	14	stimulate	stimulate	VERB
admet-394	132	15	doxorubicin	doxorubicin	NOUN
admet-394	132	16	uptake	uptake	ADJ
admet-394	132	17	revealing	reveal	VERB
admet-394	132	18	activators	activator	NOUN
admet-394	132	19	for	for	ADP
admet-394	132	20	oct-2	oct-2	NOUN
admet-394	132	21	.	.	PUNCT
admet-394	132	22	oct-1	oct-1	NUM
admet-394	132	23	and	and	CCONJ
admet-394	132	24	oct-2	oct-2	PUNCT
admet-394	132	25	play	play	VERB
admet-394	132	26	a	a	DET
admet-394	132	27	pivotal	pivotal	ADJ
admet-394	132	28	role	role	NOUN
admet-394	132	29	in	in	ADP
admet-394	132	30	controlling	control	VERB
admet-394	132	31	germ	germ	NOUN
admet-394	132	32	cell	cell	NOUN
admet-394	132	33	death	death	NOUN
admet-394	132	34	in	in	ADP
admet-394	132	35	a	a	DET
admet-394	132	36	manner	manner	NOUN
admet-394	132	37	similar	similar	ADJ
admet-394	132	38	to	to	ADP
admet-394	132	39	many	many	ADJ
admet-394	132	40	stem	stem	NOUN
admet-394	132	41	cell	cell	NOUN
admet-394	132	42	systems	system	NOUN
admet-394	132	43	,	,	PUNCT
admet-394	132	44	c.	c.	PROPN
admet-394	132	45	elegans	elegans	PROPN
admet-394	132	46	has	have	VERB
admet-394	132	47	a	a	DET
admet-394	132	48	self	self	NOUN
admet-394	132	49	-	-	PUNCT
admet-394	132	50	renewing	renew	VERB
admet-394	132	51	germ	germ	NOUN
admet-394	132	52	cell	cell	NOUN
admet-394	132	53	population	population	NOUN
admet-394	133	1	[	[	X
admet-394	133	2	38	38	NUM
admet-394	133	3	]	]	PUNCT
admet-394	133	4	.	.	PUNCT
admet-394	134	1	these	these	DET
admet-394	134	2	germ	germ	NOUN
admet-394	134	3	cells	cell	NOUN
admet-394	134	4	are	be	AUX
admet-394	134	5	very	very	ADV
admet-394	134	6	sensitive	sensitive	ADJ
admet-394	134	7	to	to	ADP
admet-394	134	8	genotoxic	genotoxic	ADJ
admet-394	134	9	compounds	compound	NOUN
admet-394	134	10	and	and	CCONJ
admet-394	134	11	respond	respond	VERB
admet-394	134	12	by	by	ADP
admet-394	134	13	using	use	VERB
admet-394	134	14	conserved	conserve	VERB
admet-394	134	15	dna	dna	PROPN
admet-394	134	16	repair	repair	NOUN
admet-394	134	17	mechanisms	mechanism	NOUN
admet-394	134	18	to	to	PART
admet-394	134	19	faithfully	faithfully	ADV
admet-394	134	20	maintain	maintain	VERB
admet-394	134	21	genomic	genomic	ADJ
admet-394	134	22	stability	stability	NOUN
admet-394	134	23	[	[	X
admet-394	134	24	39	39	NUM
admet-394	134	25	]	]	PUNCT
admet-394	134	26	.	.	PUNCT
admet-394	135	1	germ	germ	NOUN
admet-394	135	2	cells	cell	NOUN
admet-394	135	3	with	with	ADP
admet-394	135	4	extensive	extensive	ADJ
admet-394	135	5	dna	dna	NOUN
admet-394	135	6	damage	damage	NOUN
admet-394	135	7	undergo	undergo	VERB
admet-394	135	8	apoptosis	apoptosis	NOUN
admet-394	135	9	and	and	CCONJ
admet-394	135	10	can	can	AUX
admet-394	135	11	not	not	PART
admet-394	135	12	form	form	VERB
admet-394	135	13	viable	viable	ADJ
admet-394	135	14	embryos	embryo	NOUN
admet-394	135	15	,	,	PUNCT
admet-394	135	16	and	and	CCONJ
admet-394	135	17	which	which	PRON
admet-394	135	18	can	can	AUX
admet-394	135	19	be	be	AUX
admet-394	135	20	quantified	quantify	VERB
admet-394	135	21	in	in	ADP
admet-394	135	22	vivo	vivo	NOUN
admet-394	135	23	by	by	ADP
admet-394	135	24	examining	examine	VERB
admet-394	135	25	for	for	ADP
admet-394	135	26	corpses	corpse	NOUN
admet-394	135	27	in	in	ADP
admet-394	135	28	the	the	DET
admet-394	135	29	proximal	proximal	ADJ
admet-394	135	30	zone	zone	NOUN
admet-394	135	31	of	of	ADP
admet-394	135	32	the	the	DET
admet-394	135	33	gonad	gonad	ADJ
admet-394	135	34	arm	arm	NOUN
admet-394	136	1	[	[	X
admet-394	136	2	38	38	NUM
admet-394	136	3	,	,	PUNCT
admet-394	136	4	40	40	NUM
admet-394	136	5	,	,	PUNCT
admet-394	136	6	41	41	NUM
admet-394	136	7	]	]	PUNCT
admet-394	136	8	.	.	PUNCT
admet-394	137	1	these	these	DET
admet-394	137	2	corpses	corpse	NOUN
admet-394	137	3	are	be	AUX
admet-394	137	4	easily	easily	ADV
admet-394	137	5	seen	see	VERB
admet-394	137	6	by	by	ADP
admet-394	137	7	staining	stain	VERB
admet-394	137	8	with	with	ADP
admet-394	137	9	the	the	DET
admet-394	137	10	dna	dna	PROPN
admet-394	137	11	dye	dye	PROPN
admet-394	137	12	acridine	acridine	PROPN
admet-394	137	13	orange	orange	PROPN
admet-394	138	1	[	[	X
admet-394	138	2	38	38	NUM
admet-394	138	3	,	,	PUNCT
admet-394	138	4	40	40	NUM
admet-394	138	5	,	,	PUNCT
admet-394	138	6	41	41	NUM
admet-394	138	7	]	]	PUNCT
admet-394	138	8	.	.	PUNCT
admet-394	139	1	thus	thus	ADV
admet-394	139	2	,	,	PUNCT
admet-394	139	3	germ	germ	NOUN
admet-394	139	4	cell	cell	NOUN
admet-394	139	5	apoptosis	apoptosis	NOUN
admet-394	139	6	is	be	AUX
admet-394	139	7	a	a	DET
admet-394	139	8	suitable	suitable	ADJ
admet-394	139	9	in	in	ADP
admet-394	139	10	vivo	vivo	ADJ
admet-394	139	11	reporter	reporter	NOUN
admet-394	139	12	system	system	NOUN
admet-394	139	13	to	to	PART
admet-394	139	14	determine	determine	VERB
admet-394	139	15	whether	whether	SCONJ
admet-394	139	16	natural	natural	ADJ
admet-394	139	17	compounds	compound	NOUN
admet-394	139	18	and	and	CCONJ
admet-394	139	19	those	those	PRON
admet-394	139	20	in	in	ADP
admet-394	139	21	the	the	DET
admet-394	139	22	growth	growth	NOUN
admet-394	139	23	environment	environment	NOUN
admet-394	139	24	of	of	ADP
admet-394	139	25	the	the	DET
admet-394	139	26	animals	animal	NOUN
admet-394	139	27	are	be	AUX
admet-394	139	28	genotoxic	genotoxic	ADJ
admet-394	139	29	.	.	PUNCT
admet-394	140	1	we	we	PRON
admet-394	140	2	took	take	VERB
admet-394	140	3	advantage	advantage	NOUN
admet-394	140	4	of	of	ADP
admet-394	140	5	this	this	DET
admet-394	140	6	reporter	reporter	NOUN
admet-394	140	7	system	system	NOUN
admet-394	140	8	to	to	PART
admet-394	140	9	assess	assess	VERB
admet-394	140	10	whether	whether	SCONJ
admet-394	140	11	oct-1	oct-1	ADV
admet-394	140	12	and	and	CCONJ
admet-394	140	13	oct-2	oct-2	PUNCT
admet-394	140	14	control	control	VERB
admet-394	140	15	the	the	DET
admet-394	140	16	extent	extent	NOUN
admet-394	140	17	of	of	ADP
admet-394	140	18	germ	germ	NOUN
admet-394	140	19	cell	cell	NOUN
admet-394	140	20	death	death	NOUN
admet-394	140	21	triggered	trigger	VERB
admet-394	140	22	by	by	ADP
admet-394	140	23	genotoxic	genotoxic	ADJ
admet-394	140	24	agents	agent	NOUN
admet-394	140	25	,	,	PUNCT
admet-394	140	26	in	in	ADP
admet-394	140	27	particular	particular	ADJ
admet-394	140	28	,	,	PUNCT
admet-394	140	29	those	those	DET
admet-394	140	30	compounds	compound	NOUN
admet-394	140	31	that	that	PRON
admet-394	140	32	can	can	AUX
admet-394	140	33	not	not	PART
admet-394	140	34	be	be	AUX
admet-394	140	35	tracked	track	VERB
admet-394	140	36	directly	directly	ADV
admet-394	140	37	for	for	ADP
admet-394	140	38	their	their	PRON
admet-394	140	39	uptake	uptake	ADJ
admet-394	140	40	kinetics	kinetic	NOUN
admet-394	140	41	due	due	ADP
admet-394	140	42	to	to	ADP
admet-394	140	43	the	the	DET
admet-394	140	44	absence	absence	NOUN
admet-394	140	45	of	of	ADP
admet-394	140	46	a	a	DET
admet-394	140	47	fluorescence	fluorescence	NOUN
admet-394	140	48	signal	signal	NOUN
admet-394	140	49	or	or	CCONJ
admet-394	140	50	the	the	DET
admet-394	140	51	availability	availability	NOUN
admet-394	140	52	of	of	ADP
admet-394	140	53	radioactively	radioactively	NOUN
admet-394	140	54	labeled	label	VERB
admet-394	140	55	form	form	NOUN
admet-394	140	56	.	.	PUNCT
admet-394	141	1	in	in	ADP
admet-394	141	2	the	the	DET
admet-394	141	3	wild	wild	ADJ
admet-394	141	4	type	type	NOUN
admet-394	141	5	animals	animal	NOUN
admet-394	141	6	grown	grow	VERB
admet-394	141	7	under	under	ADP
admet-394	141	8	normal	normal	ADJ
admet-394	141	9	conditions	condition	NOUN
admet-394	141	10	,	,	PUNCT
admet-394	141	11	there	there	PRON
admet-394	141	12	are	be	VERB
admet-394	141	13	typically	typically	ADV
admet-394	141	14	two	two	NUM
admet-394	141	15	to	to	PART
admet-394	141	16	four	four	NUM
admet-394	141	17	germ	germ	NOUN
admet-394	141	18	cell	cell	NOUN
admet-394	141	19	corpses	corpse	NOUN
admet-394	141	20	[	[	X
admet-394	141	21	42	42	NUM
admet-394	141	22	]	]	PUNCT
admet-394	141	23	.	.	PUNCT
admet-394	142	1	however	however	ADV
admet-394	142	2	,	,	PUNCT
admet-394	142	3	when	when	SCONJ
admet-394	142	4	oct-1	oct-1	ADV
admet-394	142	5	is	be	AUX
admet-394	142	6	downregulated	downregulate	VERB
admet-394	142	7	the	the	DET
admet-394	142	8	animals	animal	NOUN
admet-394	142	9	depicted	depict	VERB
admet-394	142	10	an	an	DET
admet-394	142	11	average	average	NOUN
admet-394	142	12	of	of	ADP
admet-394	142	13	five	five	NUM
admet-394	142	14	to	to	PART
admet-394	142	15	eight	eight	NUM
admet-394	142	16	apoptotic	apoptotic	ADJ
admet-394	142	17	cells	cell	NOUN
admet-394	142	18	,	,	PUNCT
admet-394	142	19	perhaps	perhaps	ADV
admet-394	142	20	resulting	result	VERB
admet-394	142	21	from	from	ADP
admet-394	142	22	an	an	DET
admet-394	142	23	increase	increase	NOUN
admet-394	142	24	import	import	NOUN
admet-394	142	25	of	of	ADP
admet-394	142	26	genotoxic	genotoxic	ADJ
admet-394	142	27	prooxidants	prooxidant	NOUN
admet-394	142	28	by	by	ADP
admet-394	142	29	the	the	DET
admet-394	142	30	elevated	elevated	ADJ
admet-394	142	31	levels	level	NOUN
admet-394	142	32	of	of	ADP
admet-394	142	33	the	the	DET
admet-394	142	34	oct-2	oct-2	NOUN
admet-394	142	35	transporter	transporter	NOUN
admet-394	142	36	leading	lead	VERB
admet-394	142	37	to	to	ADP
admet-394	142	38	dead	dead	ADJ
admet-394	142	39	embryos	embryo	NOUN
admet-394	142	40	[	[	X
admet-394	142	41	33	33	NUM
admet-394	142	42	]	]	PUNCT
admet-394	142	43	.	.	PUNCT
admet-394	143	1	interestingly	interestingly	ADV
admet-394	143	2	,	,	PUNCT
admet-394	143	3	downregulation	downregulation	NOUN
admet-394	143	4	of	of	ADP
admet-394	143	5	oct-2	oct-2	NUM
admet-394	143	6	in	in	ADP
admet-394	143	7	the	the	DET
admet-394	143	8	oct-1	oct-1	ADV
admet-394	143	9	null	null	ADJ
admet-394	143	10	mutant	mutant	NOUN
admet-394	143	11	reduced	reduce	VERB
admet-394	143	12	the	the	DET
admet-394	143	13	germ	germ	NOUN
admet-394	143	14	cell	cell	NOUN
admet-394	143	15	death	death	NOUN
admet-394	143	16	,	,	PUNCT
admet-394	143	17	and	and	CCONJ
admet-394	143	18	in	in	ADP
admet-394	143	19	some	some	DET
admet-394	143	20	animals	animal	NOUN
admet-394	143	21	to	to	ADP
admet-394	143	22	undetectable	undetectable	ADJ
admet-394	143	23	level	level	NOUN
admet-394	143	24	.	.	PUNCT
admet-394	144	1	it	it	PRON
admet-394	144	2	seems	seem	VERB
admet-394	144	3	that	that	SCONJ
admet-394	144	4	oct-2	oct-2	PRON
admet-394	144	5	dindial	dindial	ADJ
admet-394	144	6	ramotar	ramotar	PROPN
admet-394	144	7	admet	admet	PROPN
admet-394	144	8	&	&	CCONJ
admet-394	144	9	dmpk	dmpk	PROPN
admet-394	144	10	5(3	5(3	NUM
admet-394	144	11	)	)	PUNCT
admet-394	144	12	(	(	PUNCT
admet-394	144	13	2017	2017	NUM
admet-394	144	14	)	)	PUNCT
admet-394	144	15	146	146	NUM
admet-394	144	16	-	-	SYM
admet-394	144	17	158	158	NUM
admet-394	144	18	152	152	NUM
admet-394	144	19	possesses	possess	VERB
admet-394	144	20	the	the	DET
admet-394	144	21	ability	ability	NOUN
admet-394	144	22	to	to	PART
admet-394	144	23	recognize	recognize	VERB
admet-394	144	24	and	and	CCONJ
admet-394	144	25	transport	transport	VERB
admet-394	144	26	toxic	toxic	ADJ
admet-394	144	27	compounds	compound	NOUN
admet-394	144	28	from	from	ADP
admet-394	144	29	the	the	DET
admet-394	144	30	growth	growth	NOUN
admet-394	144	31	environment	environment	NOUN
admet-394	144	32	into	into	ADP
admet-394	144	33	the	the	DET
admet-394	144	34	animals	animal	NOUN
admet-394	144	35	which	which	PRON
admet-394	144	36	then	then	ADV
admet-394	144	37	induced	induce	VERB
admet-394	144	38	germ	germ	NOUN
admet-394	144	39	cell	cell	NOUN
admet-394	144	40	death	death	NOUN
admet-394	144	41	.	.	PUNCT
admet-394	145	1	at	at	ADP
admet-394	145	2	least	least	ADJ
admet-394	145	3	,	,	PUNCT
admet-394	145	4	these	these	DET
admet-394	145	5	toxic	toxic	ADJ
admet-394	145	6	compounds	compound	NOUN
admet-394	145	7	can	can	AUX
admet-394	145	8	turn	turn	VERB
admet-394	145	9	on	on	ADP
admet-394	145	10	the	the	DET
admet-394	145	11	oxidative	oxidative	ADJ
admet-394	145	12	stress	stress	NOUN
admet-394	145	13	reporter	reporter	NOUN
admet-394	145	14	gst-4::gfp	gst-4::gfp	PROPN
admet-394	145	15	,	,	PUNCT
admet-394	145	16	suggesting	suggest	VERB
admet-394	145	17	that	that	SCONJ
admet-394	145	18	they	they	PRON
admet-394	145	19	compose	compose	VERB
admet-394	145	20	of	of	ADP
admet-394	145	21	prooxidants	prooxidant	NOUN
admet-394	145	22	with	with	ADP
admet-394	145	23	the	the	DET
admet-394	145	24	ability	ability	NOUN
admet-394	145	25	to	to	PART
admet-394	145	26	cause	cause	VERB
admet-394	145	27	genotoxicity	genotoxicity	NOUN
admet-394	145	28	in	in	ADP
admet-394	145	29	various	various	ADJ
admet-394	145	30	tissues	tissue	NOUN
admet-394	146	1	[	[	X
admet-394	146	2	33	33	NUM
admet-394	146	3	]	]	PUNCT
admet-394	146	4	.	.	PUNCT
admet-394	147	1	in	in	ADP
admet-394	147	2	fact	fact	NOUN
admet-394	147	3	,	,	PUNCT
admet-394	147	4	the	the	DET
admet-394	147	5	oct-1	oct-1	ADV
admet-394	147	6	deficient	deficient	ADJ
admet-394	147	7	animals	animal	NOUN
admet-394	147	8	produce	produce	VERB
admet-394	147	9	an	an	DET
admet-394	147	10	elevated	elevated	ADJ
admet-394	147	11	level	level	NOUN
admet-394	147	12	of	of	ADP
admet-394	147	13	dead	dead	ADJ
admet-394	147	14	embryos	embryo	NOUN
admet-394	147	15	,	,	PUNCT
admet-394	147	16	which	which	PRON
admet-394	147	17	are	be	AUX
admet-394	147	18	believed	believe	VERB
admet-394	147	19	to	to	PART
admet-394	147	20	be	be	AUX
admet-394	147	21	the	the	DET
admet-394	147	22	result	result	NOUN
admet-394	147	23	of	of	ADP
admet-394	147	24	the	the	DET
admet-394	147	25	accumulation	accumulation	NOUN
admet-394	147	26	of	of	ADP
admet-394	147	27	genotoxic	genotoxic	ADJ
admet-394	147	28	dna	dna	PROPN
admet-394	147	29	lesions	lesion	NOUN
admet-394	147	30	under	under	ADP
admet-394	147	31	normal	normal	ADJ
admet-394	147	32	growth	growth	NOUN
admet-394	147	33	conditions	condition	NOUN
admet-394	147	34	,	,	PUNCT
admet-394	147	35	and	and	CCONJ
admet-394	147	36	therefore	therefore	ADV
admet-394	147	37	account	account	VERB
admet-394	147	38	for	for	ADP
admet-394	147	39	the	the	DET
admet-394	147	40	reduced	reduce	VERB
admet-394	147	41	lifespan	lifespan	NOUN
admet-394	147	42	observed	observe	VERB
admet-394	147	43	in	in	ADP
admet-394	147	44	these	these	DET
admet-394	147	45	animals	animal	NOUN
admet-394	147	46	.	.	PUNCT
admet-394	148	1	since	since	SCONJ
admet-394	148	2	doxorubicin	doxorubicin	PROPN
admet-394	148	3	acts	act	VERB
admet-394	148	4	by	by	ADP
admet-394	148	5	damaging	damage	VERB
admet-394	148	6	the	the	DET
admet-394	148	7	dna	dna	NOUN
admet-394	148	8	and	and	CCONJ
admet-394	148	9	previously	previously	ADV
admet-394	148	10	shown	show	VERB
admet-394	148	11	to	to	PART
admet-394	148	12	trigger	trigger	VERB
admet-394	148	13	germ	germ	NOUN
admet-394	148	14	cell	cell	NOUN
admet-394	148	15	apoptosis	apoptosis	NOUN
admet-394	148	16	in	in	ADP
admet-394	148	17	c.	c.	PROPN
admet-394	148	18	elegans	elegan	NOUN
admet-394	148	19	[	[	X
admet-394	148	20	43	43	NUM
admet-394	148	21	]	]	PUNCT
admet-394	148	22	,	,	PUNCT
admet-394	148	23	then	then	ADV
admet-394	148	24	modulating	modulate	VERB
admet-394	148	25	oct-2	oct-2	DET
admet-394	148	26	level	level	NOUN
admet-394	148	27	should	should	AUX
admet-394	148	28	determine	determine	VERB
admet-394	148	29	the	the	DET
admet-394	148	30	extent	extent	NOUN
admet-394	148	31	of	of	ADP
admet-394	148	32	doxorubicin	doxorubicin	PROPN
admet-394	148	33	-	-	PUNCT
admet-394	148	34	induced	induce	VERB
admet-394	148	35	germ	germ	NOUN
admet-394	148	36	cell	cell	NOUN
admet-394	148	37	death	death	NOUN
admet-394	148	38	.	.	PUNCT
admet-394	149	1	indeed	indeed	ADV
admet-394	149	2	,	,	PUNCT
admet-394	149	3	oct-1	oct-1	NUM
admet-394	149	4	deletion	deletion	NOUN
admet-394	149	5	animals	animal	NOUN
admet-394	149	6	showed	show	VERB
admet-394	149	7	substantial	substantial	ADJ
admet-394	149	8	levels	level	NOUN
admet-394	149	9	of	of	ADP
admet-394	149	10	germ	germ	NOUN
admet-394	149	11	cell	cell	NOUN
admet-394	149	12	deaths	death	NOUN
admet-394	149	13	when	when	SCONJ
admet-394	149	14	treated	treat	VERB
admet-394	149	15	with	with	ADP
admet-394	149	16	doxorubicin	doxorubicin	PROPN
admet-394	149	17	,	,	PUNCT
admet-394	149	18	as	as	SCONJ
admet-394	149	19	opposed	oppose	VERB
admet-394	149	20	to	to	ADP
admet-394	149	21	the	the	DET
admet-394	149	22	wild	wild	NOUN
admet-394	149	23	-	-	PUNCT
admet-394	149	24	type	type	NOUN
admet-394	149	25	.	.	PUNCT
admet-394	150	1	this	this	DET
admet-394	150	2	phenomenon	phenomenon	NOUN
admet-394	150	3	was	be	AUX
admet-394	150	4	greatly	greatly	ADV
admet-394	150	5	diminished	diminish	VERB
admet-394	150	6	following	follow	VERB
admet-394	150	7	oct-2	oct-2	NOUN
admet-394	150	8	downregulation	downregulation	NOUN
admet-394	150	9	in	in	ADP
admet-394	150	10	the	the	DET
admet-394	150	11	doxorubicin	doxorubicin	PROPN
admet-394	150	12	treated	treat	VERB
admet-394	150	13	oct-1	oct-1	ADV
admet-394	150	14	null	null	ADJ
admet-394	150	15	animals	animal	NOUN
admet-394	150	16	.	.	PUNCT
admet-394	151	1	these	these	DET
admet-394	151	2	observations	observation	NOUN
admet-394	151	3	are	be	AUX
admet-394	151	4	consistent	consistent	ADJ
admet-394	151	5	with	with	ADP
admet-394	151	6	the	the	DET
admet-394	151	7	model	model	NOUN
admet-394	151	8	that	that	SCONJ
admet-394	151	9	oct-1	oct-1	ADJ
admet-394	151	10	deletion	deletion	NOUN
admet-394	151	11	led	lead	VERB
admet-394	151	12	to	to	ADP
admet-394	151	13	oct-2	oct-2	SYM
admet-394	151	14	upregulation	upregulation	NOUN
admet-394	151	15	,	,	PUNCT
admet-394	151	16	which	which	PRON
admet-394	151	17	then	then	ADV
admet-394	151	18	mediates	mediate	VERB
admet-394	151	19	doxorubicin	doxorubicin	PROPN
admet-394	151	20	uptake	uptake	ADJ
admet-394	151	21	that	that	PRON
admet-394	151	22	induces	induce	VERB
admet-394	151	23	germ	germ	NOUN
admet-394	151	24	cell	cell	NOUN
admet-394	151	25	death	death	NOUN
admet-394	151	26	.	.	PUNCT
admet-394	152	1	therefore	therefore	ADV
admet-394	152	2	,	,	PUNCT
admet-394	152	3	germ	germ	NOUN
admet-394	152	4	cell	cell	NOUN
admet-394	152	5	death	death	NOUN
admet-394	152	6	is	be	AUX
admet-394	152	7	a	a	DET
admet-394	152	8	genuine	genuine	ADJ
admet-394	152	9	reporter	reporter	NOUN
admet-394	152	10	for	for	ADP
admet-394	152	11	oct-2	oct-2	NOUN
admet-394	152	12	dependent	dependent	ADJ
admet-394	152	13	uptake	uptake	NOUN
admet-394	152	14	of	of	ADP
admet-394	152	15	genotoxic	genotoxic	ADJ
admet-394	152	16	agents	agent	NOUN
admet-394	152	17	.	.	PUNCT
admet-394	153	1	potential	potential	ADJ
admet-394	153	2	substrates	substrate	NOUN
admet-394	153	3	of	of	ADP
admet-394	153	4	oct-2	oct-2	NOUN
admet-394	153	5	while	while	SCONJ
admet-394	153	6	it	it	PRON
admet-394	153	7	is	be	AUX
admet-394	153	8	clear	clear	ADJ
admet-394	153	9	that	that	SCONJ
admet-394	153	10	additional	additional	ADJ
admet-394	153	11	substrates	substrate	NOUN
admet-394	153	12	will	will	AUX
admet-394	153	13	be	be	AUX
admet-394	153	14	recognized	recognize	VERB
admet-394	153	15	by	by	ADP
admet-394	153	16	oct-2	oct-2	NOUN
admet-394	154	1	,	,	PUNCT
admet-394	154	2	it	it	PRON
admet-394	154	3	is	be	AUX
admet-394	154	4	an	an	DET
admet-394	154	5	arduous	arduous	ADJ
admet-394	154	6	task	task	NOUN
admet-394	154	7	to	to	PART
admet-394	154	8	test	test	VERB
admet-394	154	9	each	each	DET
admet-394	154	10	potential	potential	ADJ
admet-394	154	11	substrate	substrate	NOUN
admet-394	154	12	,	,	PUNCT
admet-394	154	13	for	for	ADP
admet-394	154	14	example	example	NOUN
admet-394	154	15	,	,	PUNCT
admet-394	154	16	by	by	ADP
admet-394	154	17	competing	compete	VERB
admet-394	154	18	for	for	ADP
admet-394	154	19	doxorubicin	doxorubicin	PROPN
admet-394	154	20	uptake	uptake	VERB
admet-394	154	21	.	.	PUNCT
admet-394	155	1	as	as	ADP
admet-394	155	2	such	such	ADJ
admet-394	155	3	,	,	PUNCT
admet-394	155	4	we	we	PRON
admet-394	155	5	undertook	undertake	VERB
admet-394	155	6	an	an	DET
admet-394	155	7	in	in	ADP
admet-394	155	8	silico	silico	NOUN
admet-394	155	9	approach	approach	NOUN
admet-394	155	10	by	by	ADP
admet-394	155	11	first	first	ADV
admet-394	155	12	making	make	VERB
admet-394	155	13	predictions	prediction	NOUN
admet-394	155	14	of	of	ADP
admet-394	155	15	the	the	DET
admet-394	155	16	structure	structure	NOUN
admet-394	155	17	of	of	ADP
admet-394	155	18	the	the	DET
admet-394	155	19	transporter	transporter	NOUN
admet-394	155	20	using	use	VERB
admet-394	155	21	the	the	DET
admet-394	155	22	i	i	NOUN
admet-394	155	23	-	-	PUNCT
admet-394	155	24	tasser	tasser	NOUN
admet-394	155	25	protein	protein	NOUN
admet-394	155	26	structure	structure	NOUN
admet-394	155	27	prediction	prediction	NOUN
admet-394	155	28	server	server	NOUN
admet-394	155	29	[	[	X
admet-394	155	30	44	44	NUM
admet-394	155	31	]	]	PUNCT
admet-394	155	32	.	.	PUNCT
admet-394	156	1	the	the	DET
admet-394	156	2	analysis	analysis	NOUN
admet-394	156	3	predicted	predict	VERB
admet-394	156	4	3d	3d	NUM
admet-394	156	5	structures	structure	NOUN
admet-394	156	6	not	not	PART
admet-394	156	7	only	only	ADV
admet-394	156	8	for	for	ADP
admet-394	156	9	oct-2	oct-2	NUM
admet-394	156	10	,	,	PUNCT
admet-394	156	11	but	but	CCONJ
admet-394	156	12	also	also	ADV
admet-394	156	13	oct-1	oct-1	ADV
admet-394	156	14	,	,	PUNCT
admet-394	156	15	revealing	reveal	VERB
admet-394	156	16	that	that	SCONJ
admet-394	156	17	both	both	PRON
admet-394	156	18	possessed	possess	VERB
admet-394	156	19	the	the	DET
admet-394	156	20	entire	entire	ADJ
admet-394	156	21	12	12	NUM
admet-394	156	22	transmembrane	transmembrane	ADJ
admet-394	156	23	domain	domain	NOUN
admet-394	156	24	helices	helix	NOUN
admet-394	156	25	and	and	CCONJ
admet-394	156	26	belonging	belong	VERB
admet-394	156	27	to	to	ADP
admet-394	156	28	the	the	DET
admet-394	156	29	solute	solute	ADJ
admet-394	156	30	carrier	carrier	NOUN
admet-394	156	31	transporter	transporter	NOUN
admet-394	156	32	family	family	NOUN
admet-394	157	1	[	[	X
admet-394	157	2	33	33	NUM
admet-394	157	3	,	,	PUNCT
admet-394	157	4	45	45	NUM
admet-394	157	5	]	]	PUNCT
admet-394	157	6	.	.	PUNCT
admet-394	158	1	the	the	DET
admet-394	158	2	predicted	predict	VERB
admet-394	158	3	3d	3d	NUM
admet-394	158	4	structures	structure	NOUN
admet-394	158	5	of	of	ADP
admet-394	158	6	the	the	DET
admet-394	158	7	transporters	transporter	NOUN
admet-394	158	8	were	be	AUX
admet-394	158	9	then	then	ADV
admet-394	158	10	modeled	model	VERB
admet-394	158	11	with	with	ADP
admet-394	158	12	drugs	drug	NOUN
admet-394	158	13	to	to	PART
admet-394	158	14	look	look	VERB
admet-394	158	15	for	for	ADP
admet-394	158	16	interactions	interaction	NOUN
admet-394	158	17	using	use	VERB
admet-394	158	18	the	the	DET
admet-394	158	19	bsp	bsp	NOUN
admet-394	158	20	-	-	PUNCT
admet-394	158	21	slim	slim	ADJ
admet-394	158	22	and	and	CCONJ
admet-394	158	23	coach	coach	NOUN
admet-394	158	24	algorithms	algorithm	NOUN
admet-394	158	25	.	.	PUNCT
admet-394	159	1	these	these	DET
admet-394	159	2	programs	program	NOUN
admet-394	159	3	approximate	approximate	VERB
admet-394	159	4	the	the	DET
admet-394	159	5	amino	amino	NOUN
admet-394	159	6	acid	acid	NOUN
admet-394	159	7	residues	residue	NOUN
admet-394	159	8	of	of	ADP
admet-394	159	9	the	the	DET
admet-394	159	10	transporters	transporter	NOUN
admet-394	159	11	constituting	constitute	VERB
admet-394	159	12	the	the	DET
admet-394	159	13	ligand	ligand	ADJ
admet-394	159	14	–	–	PUNCT
admet-394	159	15	protein	protein	NOUN
admet-394	159	16	docking	docking	NOUN
admet-394	159	17	sites	site	NOUN
admet-394	159	18	and	and	CCONJ
admet-394	159	19	thereby	thereby	ADV
admet-394	159	20	resulting	result	VERB
admet-394	159	21	in	in	ADP
admet-394	159	22	a	a	DET
admet-394	159	23	docking	docking	NOUN
admet-394	159	24	score	score	NOUN
admet-394	160	1	[	[	X
admet-394	160	2	46	46	NUM
admet-394	160	3	,	,	PUNCT
admet-394	160	4	47	47	NUM
admet-394	160	5	]	]	PUNCT
admet-394	160	6	.	.	PUNCT
admet-394	161	1	a	a	DET
admet-394	161	2	number	number	NOUN
admet-394	161	3	of	of	ADP
admet-394	161	4	drugs	drug	NOUN
admet-394	161	5	were	be	AUX
admet-394	161	6	analyzed	analyze	VERB
admet-394	161	7	and	and	CCONJ
admet-394	161	8	these	these	PRON
admet-394	161	9	were	be	AUX
admet-394	161	10	mostly	mostly	ADV
admet-394	161	11	dna	dna	ADJ
admet-394	161	12	damaging	damage	VERB
admet-394	161	13	agents	agent	NOUN
admet-394	161	14	including	include	VERB
admet-394	161	15	cisplatin	cisplatin	NOUN
admet-394	161	16	and	and	CCONJ
admet-394	161	17	camptothecin	camptothecin	NOUN
admet-394	161	18	and	and	CCONJ
admet-394	161	19	small	small	ADJ
admet-394	161	20	molecules	molecule	NOUN
admet-394	161	21	with	with	ADP
admet-394	161	22	the	the	DET
admet-394	161	23	ability	ability	NOUN
admet-394	161	24	to	to	PART
admet-394	161	25	inhibit	inhibit	VERB
admet-394	161	26	dna	dna	PROPN
admet-394	161	27	repair	repair	NOUN
admet-394	161	28	such	such	ADJ
admet-394	161	29	as	as	ADP
admet-394	161	30	olaparib	olaparib	NOUN
admet-394	161	31	and	and	CCONJ
admet-394	161	32	methoxyamine	methoxyamine	NOUN
admet-394	161	33	.	.	PUNCT
admet-394	162	1	of	of	ADP
admet-394	162	2	the	the	DET
admet-394	162	3	19	19	NUM
admet-394	162	4	potential	potential	ADJ
admet-394	162	5	substrates	substrate	NOUN
admet-394	162	6	,	,	PUNCT
admet-394	162	7	four	four	NUM
admet-394	162	8	resulted	result	VERB
admet-394	162	9	with	with	ADP
admet-394	162	10	a	a	DET
admet-394	162	11	docking	dock	VERB
admet-394	162	12	score	score	NOUN
admet-394	162	13	of	of	ADP
admet-394	162	14	zero	zero	NUM
admet-394	162	15	,	,	PUNCT
admet-394	162	16	whereas	whereas	SCONJ
admet-394	162	17	the	the	DET
admet-394	162	18	other	other	ADJ
admet-394	162	19	15	15	NUM
admet-394	162	20	revealed	reveal	VERB
admet-394	162	21	docking	docking	NOUN
admet-394	162	22	scores	score	NOUN
admet-394	162	23	>	>	X
admet-394	162	24	3.5	3.5	NUM
admet-394	162	25	[	[	SYM
admet-394	162	26	33	33	NUM
admet-394	162	27	]	]	PUNCT
admet-394	162	28	.	.	PUNCT
admet-394	163	1	many	many	ADJ
admet-394	163	2	showed	show	VERB
admet-394	163	3	higher	high	ADJ
admet-394	163	4	docking	docking	NOUN
admet-394	163	5	scores	score	NOUN
admet-394	163	6	with	with	ADP
admet-394	163	7	oct-2	oct-2	NUM
admet-394	163	8	than	than	ADP
admet-394	163	9	oct-1	oct-1	NOUN
admet-394	163	10	,	,	PUNCT
admet-394	163	11	favoring	favor	VERB
admet-394	163	12	robust	robust	ADJ
admet-394	163	13	binding	binding	NOUN
admet-394	163	14	to	to	ADP
admet-394	163	15	oct-2	oct-2	NUM
admet-394	163	16	[	[	X
admet-394	163	17	33	33	NUM
admet-394	163	18	]	]	PUNCT
admet-394	163	19	.	.	PUNCT
admet-394	164	1	from	from	ADP
admet-394	164	2	the	the	DET
admet-394	164	3	molecules	molecule	NOUN
admet-394	164	4	tested	test	VERB
admet-394	164	5	,	,	PUNCT
admet-394	164	6	it	it	PRON
admet-394	164	7	seems	seem	VERB
admet-394	164	8	that	that	SCONJ
admet-394	164	9	oct-2	oct-2	PRON
admet-394	164	10	may	may	AUX
admet-394	164	11	distinguish	distinguish	VERB
admet-394	164	12	specific	specific	ADJ
admet-394	164	13	substrates	substrate	NOUN
admet-394	164	14	to	to	PART
admet-394	164	15	be	be	AUX
admet-394	164	16	transported	transport	VERB
admet-394	164	17	into	into	ADP
admet-394	164	18	c.	c.	PROPN
admet-394	164	19	elegans	elegan	NOUN
admet-394	164	20	tissues	tissue	NOUN
admet-394	164	21	by	by	ADP
admet-394	164	22	recognizing	recognize	VERB
admet-394	164	23	an	an	DET
admet-394	164	24	overall	overall	ADJ
admet-394	164	25	positive	positive	ADJ
admet-394	164	26	charge	charge	NOUN
admet-394	164	27	and	and	CCONJ
admet-394	164	28	perhaps	perhaps	ADV
admet-394	164	29	structural	structural	ADJ
admet-394	164	30	features	feature	NOUN
admet-394	164	31	that	that	PRON
admet-394	164	32	include	include	VERB
admet-394	164	33	aromatic	aromatic	ADJ
admet-394	164	34	groups	group	NOUN
admet-394	164	35	.	.	PUNCT
admet-394	165	1	it	it	PRON
admet-394	165	2	is	be	AUX
admet-394	165	3	noteworthy	noteworthy	ADJ
admet-394	165	4	that	that	SCONJ
admet-394	165	5	there	there	PRON
admet-394	165	6	are	be	VERB
admet-394	165	7	compounds	compound	NOUN
admet-394	165	8	that	that	PRON
admet-394	165	9	can	can	AUX
admet-394	165	10	damage	damage	VERB
admet-394	165	11	the	the	DET
admet-394	165	12	dna	dna	NOUN
admet-394	165	13	and	and	CCONJ
admet-394	165	14	induce	induce	VERB
admet-394	165	15	apoptotic	apoptotic	ADJ
admet-394	165	16	corpses	corpse	NOUN
admet-394	165	17	such	such	ADJ
admet-394	165	18	as	as	ADP
admet-394	165	19	melphalan	melphalan	NOUN
admet-394	165	20	and	and	CCONJ
admet-394	165	21	methoxyamine	methoxyamine	NOUN
admet-394	165	22	.	.	PUNCT
admet-394	166	1	however	however	ADV
admet-394	166	2	,	,	PUNCT
admet-394	166	3	these	these	DET
admet-394	166	4	agents	agent	NOUN
admet-394	166	5	do	do	AUX
admet-394	166	6	not	not	PART
admet-394	166	7	dock	dock	VERB
admet-394	166	8	onto	onto	ADP
admet-394	166	9	oct-2	oct-2	NUM
admet-394	166	10	or	or	CCONJ
admet-394	166	11	oct-1	oct-1	PRON
admet-394	166	12	,	,	PUNCT
admet-394	166	13	and	and	CCONJ
admet-394	166	14	may	may	AUX
admet-394	166	15	therefore	therefore	ADV
admet-394	166	16	require	require	VERB
admet-394	166	17	alternative	alternative	ADJ
admet-394	166	18	transporters	transporter	NOUN
admet-394	166	19	to	to	PART
admet-394	166	20	enter	enter	VERB
admet-394	166	21	the	the	DET
admet-394	166	22	animals	animal	NOUN
admet-394	166	23	[	[	X
admet-394	166	24	33	33	NUM
admet-394	166	25	]	]	PUNCT
admet-394	166	26	.	.	PUNCT
admet-394	167	1	it	it	PRON
admet-394	167	2	is	be	AUX
admet-394	167	3	anticipated	anticipate	VERB
admet-394	167	4	that	that	SCONJ
admet-394	167	5	protein	protein	NOUN
admet-394	167	6	-	-	PUNCT
admet-394	167	7	ligand	ligand	NOUN
admet-394	167	8	modeling	modeling	NOUN
admet-394	167	9	studies	study	NOUN
admet-394	167	10	should	should	AUX
admet-394	167	11	reveal	reveal	VERB
admet-394	167	12	novel	novel	ADJ
admet-394	167	13	substrates	substrate	NOUN
admet-394	167	14	for	for	ADP
admet-394	167	15	these	these	DET
admet-394	167	16	uptake	uptake	ADJ
admet-394	167	17	transporters	transporter	NOUN
admet-394	167	18	,	,	PUNCT
admet-394	167	19	but	but	CCONJ
admet-394	167	20	these	these	DET
admet-394	167	21	ligands	ligand	NOUN
admet-394	167	22	must	must	AUX
admet-394	167	23	be	be	AUX
admet-394	167	24	experimentally	experimentally	ADV
admet-394	167	25	validated	validate	VERB
admet-394	167	26	as	as	ADP
admet-394	167	27	described	describe	VERB
admet-394	167	28	below	below	ADV
admet-394	167	29	for	for	ADP
admet-394	167	30	the	the	DET
admet-394	167	31	anticancer	anticancer	NOUN
admet-394	167	32	drug	drug	NOUN
admet-394	167	33	cisplatin	cisplatin	NOUN
admet-394	167	34	and	and	CCONJ
admet-394	167	35	an	an	DET
admet-394	167	36	inhibitor	inhibitor	NOUN
admet-394	167	37	of	of	ADP
admet-394	167	38	dna	dna	PROPN
admet-394	167	39	repair	repair	NOUN
admet-394	167	40	.	.	PUNCT
admet-394	168	1	oct-2	oct-2	ADJ
admet-394	168	2	-	-	PUNCT
admet-394	168	3	dependent	dependent	ADJ
admet-394	168	4	transport	transport	NOUN
admet-394	168	5	of	of	ADP
admet-394	168	6	cisplatin	cisplatin	NOUN
admet-394	168	7	stimulates	stimulate	NOUN
admet-394	168	8	germ	germ	NOUN
admet-394	168	9	cell	cell	NOUN
admet-394	168	10	death	death	NOUN
admet-394	168	11	in	in	ADP
admet-394	168	12	c.	c.	PROPN
admet-394	168	13	elegans	elegan	VERB
admet-394	168	14	mutants	mutant	NOUN
admet-394	168	15	defective	defective	ADJ
admet-394	168	16	in	in	ADP
admet-394	168	17	dna	dna	PROPN
admet-394	168	18	repair	repair	NOUN
admet-394	168	19	cisplatin	cisplatin	NOUN
admet-394	168	20	,	,	PUNCT
admet-394	168	21	a	a	DET
admet-394	168	22	predicted	predict	VERB
admet-394	168	23	ligand	ligand	NOUN
admet-394	168	24	of	of	ADP
admet-394	168	25	oct-2	oct-2	NUM
admet-394	168	26	,	,	PUNCT
admet-394	168	27	is	be	AUX
admet-394	168	28	a	a	DET
admet-394	168	29	member	member	NOUN
admet-394	168	30	of	of	ADP
admet-394	168	31	the	the	DET
admet-394	168	32	platinum	platinum	NOUN
admet-394	168	33	family	family	NOUN
admet-394	168	34	of	of	ADP
admet-394	168	35	anticancer	anticancer	NOUN
admet-394	168	36	drugs	drug	NOUN
admet-394	168	37	that	that	PRON
admet-394	168	38	damages	damage	VERB
admet-394	168	39	the	the	DET
admet-394	168	40	dna	dna	NOUN
admet-394	168	41	by	by	ADP
admet-394	168	42	creating	create	VERB
admet-394	168	43	intraand	intraand	NOUN
admet-394	168	44	inter	inter	ADJ
admet-394	168	45	-	-	ADJ
admet-394	168	46	strand	strand	ADJ
admet-394	168	47	dna	dna	PROPN
admet-394	168	48	cross	cross	NOUN
admet-394	168	49	-	-	NOUN
admet-394	168	50	links	link	NOUN
admet-394	168	51	[	[	X
admet-394	168	52	48	48	NUM
admet-394	168	53	]	]	PUNCT
admet-394	168	54	.	.	PUNCT
admet-394	169	1	these	these	DET
admet-394	169	2	dna	dna	PROPN
admet-394	169	3	lesions	lesion	NOUN
admet-394	169	4	are	be	AUX
admet-394	169	5	repaired	repair	VERB
admet-394	169	6	by	by	ADP
admet-394	169	7	the	the	DET
admet-394	169	8	nucleotide	nucleotide	PROPN
admet-394	169	9	excision	excision	PROPN
admet-394	169	10	dna	dna	PROPN
admet-394	169	11	repair	repair	NOUN
admet-394	169	12	pathway	pathway	NOUN
admet-394	169	13	,	,	PUNCT
admet-394	169	14	which	which	PRON
admet-394	169	15	has	have	VERB
admet-394	169	16	the	the	DET
admet-394	169	17	ability	ability	NOUN
admet-394	169	18	to	to	PART
admet-394	169	19	recognize	recognize	VERB
admet-394	169	20	helix	helix	ADJ
admet-394	169	21	distortion	distortion	NOUN
admet-394	169	22	followed	follow	VERB
admet-394	169	23	admet	admet	PROPN
admet-394	169	24	&	&	CCONJ
admet-394	169	25	dmpk	dmpk	PROPN
admet-394	169	26	5(3	5(3	NUM
admet-394	169	27	)	)	PUNCT
admet-394	169	28	(	(	PUNCT
admet-394	169	29	2017	2017	NUM
admet-394	169	30	)	)	PUNCT
admet-394	169	31	146	146	NUM
admet-394	169	32	-	-	SYM
admet-394	169	33	158	158	NUM
admet-394	169	34	oct-1	oct-1	NUM
admet-394	169	35	and	and	CCONJ
admet-394	169	36	oct-2	oct-2	NUM
admet-394	169	37	in	in	ADP
admet-394	169	38	caenorhabditis	caenorhabditis	PROPN
admet-394	169	39	elegans	elegan	NOUN
admet-394	169	40	doi	doi	NOUN
admet-394	169	41	:	:	PUNCT
admet-394	169	42	10.5599	10.5599	NUM
admet-394	169	43	/	/	SYM
admet-394	169	44	admet.5.3.394	admet.5.3.394	X
admet-394	169	45	153	153	NUM
admet-394	169	46	by	by	ADP
admet-394	169	47	incisions	incision	NOUN
admet-394	169	48	on	on	ADP
admet-394	169	49	either	either	DET
admet-394	169	50	side	side	NOUN
admet-394	169	51	of	of	ADP
admet-394	169	52	the	the	DET
admet-394	169	53	lesion	lesion	NOUN
admet-394	169	54	[	[	X
admet-394	169	55	49	49	NUM
admet-394	169	56	]	]	PUNCT
admet-394	169	57	.	.	PUNCT
admet-394	170	1	thus	thus	ADV
admet-394	170	2	,	,	PUNCT
admet-394	170	3	defects	defect	NOUN
admet-394	170	4	in	in	ADP
admet-394	170	5	the	the	DET
admet-394	170	6	nucleotide	nucleotide	ADJ
admet-394	170	7	excision	excision	NOUN
admet-394	170	8	repair	repair	NOUN
admet-394	170	9	pathway	pathway	NOUN
admet-394	170	10	cause	cause	VERB
admet-394	170	11	hypersensitivity	hypersensitivity	NOUN
admet-394	170	12	to	to	ADP
admet-394	170	13	cisplatin	cisplatin	NOUN
admet-394	170	14	[	[	X
admet-394	170	15	49	49	NUM
admet-394	170	16	]	]	PUNCT
admet-394	170	17	.	.	PUNCT
admet-394	171	1	as	as	SCONJ
admet-394	171	2	cisplatin	cisplatin	NOUN
admet-394	171	3	is	be	AUX
admet-394	171	4	not	not	PART
admet-394	171	5	available	available	ADJ
admet-394	171	6	in	in	ADP
admet-394	171	7	labeled	label	VERB
admet-394	171	8	forms	form	NOUN
admet-394	171	9	,	,	PUNCT
admet-394	171	10	but	but	CCONJ
admet-394	171	11	can	can	AUX
admet-394	171	12	be	be	AUX
admet-394	171	13	monitored	monitor	VERB
admet-394	171	14	by	by	ADP
admet-394	171	15	liquid	liquid	ADJ
admet-394	171	16	chromatography	chromatography	NOUN
admet-394	171	17	mass	mass	NOUN
admet-394	171	18	spectrometry	spectrometry	NOUN
admet-394	171	19	,	,	PUNCT
admet-394	171	20	the	the	DET
admet-394	171	21	germ	germ	NOUN
admet-394	171	22	cell	cell	NOUN
admet-394	171	23	apoptotic	apoptotic	ADJ
admet-394	171	24	assay	assay	NOUN
admet-394	171	25	provides	provide	VERB
admet-394	171	26	a	a	DET
admet-394	171	27	remarkable	remarkable	ADJ
admet-394	171	28	alternative	alternative	ADJ
admet-394	171	29	reporter	reporter	NOUN
admet-394	171	30	for	for	ADP
admet-394	171	31	the	the	DET
admet-394	171	32	uptake	uptake	NOUN
admet-394	171	33	of	of	ADP
admet-394	171	34	the	the	DET
admet-394	171	35	drug	drug	NOUN
admet-394	171	36	[	[	X
admet-394	171	37	39	39	NUM
admet-394	171	38	,	,	PUNCT
admet-394	171	39	50	50	NUM
admet-394	171	40	]	]	PUNCT
admet-394	171	41	.	.	PUNCT
admet-394	172	1	the	the	DET
admet-394	172	2	analysis	analysis	NOUN
admet-394	172	3	revealed	reveal	VERB
admet-394	172	4	that	that	SCONJ
admet-394	172	5	cisplatin	cisplatin	NOUN
admet-394	172	6	induced	induce	VERB
admet-394	172	7	an	an	DET
admet-394	172	8	increase	increase	NOUN
admet-394	172	9	level	level	NOUN
admet-394	172	10	of	of	ADP
admet-394	172	11	germ	germ	NOUN
admet-394	172	12	cell	cell	NOUN
admet-394	172	13	death	death	NOUN
admet-394	172	14	in	in	ADP
admet-394	172	15	the	the	DET
admet-394	172	16	wild	wild	ADJ
admet-394	172	17	type	type	NOUN
admet-394	172	18	animal	animal	NOUN
admet-394	172	19	,	,	PUNCT
admet-394	172	20	and	and	CCONJ
admet-394	172	21	which	which	PRON
admet-394	172	22	was	be	AUX
admet-394	172	23	further	far	ADV
admet-394	172	24	stimulated	stimulate	VERB
admet-394	172	25	in	in	ADP
admet-394	172	26	the	the	DET
admet-394	172	27	oct-1	oct-1	ADV
admet-394	172	28	null	null	ADJ
admet-394	172	29	mutants	mutant	NOUN
admet-394	172	30	[	[	X
admet-394	172	31	33	33	NUM
admet-394	172	32	]	]	PUNCT
admet-394	172	33	.	.	PUNCT
admet-394	173	1	downregulation	downregulation	NOUN
admet-394	173	2	of	of	ADP
admet-394	173	3	oct-2	oct-2	NUM
admet-394	173	4	in	in	ADP
admet-394	173	5	the	the	DET
admet-394	173	6	oct-1	oct-1	ADV
admet-394	173	7	null	null	ADJ
admet-394	173	8	mutants	mutant	NOUN
admet-394	173	9	prevented	prevent	VERB
admet-394	173	10	the	the	DET
admet-394	173	11	cisplatin	cisplatin	NOUN
admet-394	173	12	-	-	PUNCT
admet-394	173	13	induced	induce	VERB
admet-394	173	14	germ	germ	NOUN
admet-394	173	15	cell	cell	NOUN
admet-394	173	16	death	death	NOUN
admet-394	173	17	indicating	indicate	VERB
admet-394	173	18	that	that	SCONJ
admet-394	173	19	oct-2	oct-2	VERB
admet-394	173	20	plays	play	VERB
admet-394	173	21	a	a	DET
admet-394	173	22	central	central	ADJ
admet-394	173	23	role	role	NOUN
admet-394	173	24	in	in	ADP
admet-394	173	25	mediating	mediate	VERB
admet-394	173	26	the	the	DET
admet-394	173	27	genotoxic	genotoxic	ADJ
admet-394	173	28	effects	effect	NOUN
admet-394	173	29	of	of	ADP
admet-394	173	30	cisplatin	cisplatin	NOUN
admet-394	173	31	[	[	X
admet-394	173	32	33	33	NUM
admet-394	173	33	]	]	PUNCT
admet-394	173	34	.	.	PUNCT
admet-394	174	1	thus	thus	ADV
admet-394	174	2	,	,	PUNCT
admet-394	174	3	the	the	DET
admet-394	174	4	ligand	ligand	NOUN
admet-394	174	5	-	-	PUNCT
admet-394	174	6	docking	docking	NOUN
admet-394	174	7	studies	study	NOUN
admet-394	174	8	described	describe	VERB
admet-394	174	9	above	above	ADP
admet-394	174	10	serve	serve	VERB
admet-394	174	11	as	as	ADP
admet-394	174	12	a	a	DET
admet-394	174	13	useful	useful	ADJ
admet-394	174	14	prediction	prediction	NOUN
admet-394	174	15	platform	platform	NOUN
admet-394	174	16	to	to	PART
admet-394	174	17	screen	screen	VERB
admet-394	174	18	for	for	ADP
admet-394	174	19	oct-2	oct-2	NUM
admet-394	174	20	substrates	substrate	NOUN
admet-394	174	21	.	.	PUNCT
admet-394	175	1	one	one	NUM
admet-394	175	2	prediction	prediction	NOUN
admet-394	175	3	from	from	ADP
admet-394	175	4	these	these	DET
admet-394	175	5	findings	finding	NOUN
admet-394	175	6	is	be	AUX
admet-394	175	7	that	that	SCONJ
admet-394	175	8	the	the	DET
admet-394	175	9	elevated	elevated	ADJ
admet-394	175	10	uptake	uptake	NOUN
admet-394	175	11	of	of	ADP
admet-394	175	12	genotoxic	genotoxic	ADJ
admet-394	175	13	agents	agent	NOUN
admet-394	175	14	into	into	ADP
admet-394	175	15	animals	animal	NOUN
admet-394	175	16	defective	defective	ADJ
admet-394	175	17	in	in	ADP
admet-394	175	18	dna	dna	PROPN
admet-394	175	19	repair	repair	NOUN
admet-394	175	20	should	should	AUX
admet-394	175	21	result	result	VERB
admet-394	175	22	in	in	ADP
admet-394	175	23	lethal	lethal	ADJ
admet-394	175	24	phenotypes	phenotype	NOUN
admet-394	175	25	.	.	PUNCT
admet-394	176	1	there	there	PRON
admet-394	176	2	are	be	VERB
admet-394	176	3	several	several	ADJ
admet-394	176	4	mutants	mutant	NOUN
admet-394	176	5	in	in	ADP
admet-394	176	6	the	the	DET
admet-394	176	7	c.	c.	PROPN
admet-394	176	8	elegans	elegans	PROPN
admet-394	176	9	consortium	consortium	NOUN
admet-394	176	10	carrying	carry	VERB
admet-394	176	11	defects	defect	NOUN
admet-394	176	12	in	in	ADP
admet-394	176	13	the	the	DET
admet-394	176	14	major	major	ADJ
admet-394	176	15	dna	dna	PROPN
admet-394	176	16	repair	repair	NOUN
admet-394	176	17	pathways	pathway	NOUN
admet-394	176	18	and	and	CCONJ
admet-394	176	19	which	which	PRON
admet-394	176	20	are	be	AUX
admet-394	176	21	suitable	suitable	ADJ
admet-394	176	22	to	to	PART
admet-394	176	23	test	test	VERB
admet-394	176	24	whether	whether	SCONJ
admet-394	176	25	oct2	oct2	NOUN
admet-394	176	26	upregulation	upregulation	NOUN
admet-394	176	27	can	can	AUX
admet-394	176	28	trigger	trigger	VERB
admet-394	176	29	sensitization	sensitization	NOUN
admet-394	176	30	of	of	ADP
admet-394	176	31	the	the	DET
admet-394	176	32	animals	animal	NOUN
admet-394	176	33	to	to	PART
admet-394	176	34	dna	dna	VERB
admet-394	176	35	damage	damage	NOUN
admet-394	176	36	-	-	PUNCT
admet-394	176	37	induced	induce	VERB
admet-394	176	38	germ	germ	NOUN
admet-394	176	39	cell	cell	NOUN
admet-394	176	40	death	death	NOUN
admet-394	176	41	.	.	PUNCT
admet-394	177	1	for	for	ADP
admet-394	177	2	example	example	NOUN
admet-394	177	3	,	,	PUNCT
admet-394	177	4	the	the	DET
admet-394	177	5	xpa-1	xpa-1	ADJ
admet-394	177	6	deletion	deletion	NOUN
admet-394	177	7	mutant	mutant	NOUN
admet-394	177	8	lacking	lack	VERB
admet-394	177	9	the	the	DET
admet-394	177	10	xpa-1	xpa-1	PUNCT
admet-394	177	11	protein	protein	NOUN
admet-394	177	12	needed	need	VERB
admet-394	177	13	for	for	ADP
admet-394	177	14	nucleotide	nucleotide	ADJ
admet-394	177	15	excision	excision	NOUN
admet-394	177	16	repair	repair	NOUN
admet-394	177	17	of	of	ADP
admet-394	177	18	bulky	bulky	ADJ
admet-394	177	19	dna	dna	PROPN
admet-394	177	20	lesions	lesion	NOUN
admet-394	177	21	exhibited	exhibit	VERB
admet-394	177	22	enhance	enhance	NOUN
admet-394	177	23	germ	germ	NOUN
admet-394	177	24	cell	cell	NOUN
admet-394	177	25	death	death	NOUN
admet-394	177	26	when	when	SCONJ
admet-394	177	27	exposed	expose	VERB
admet-394	177	28	to	to	ADP
admet-394	177	29	cisplatin	cisplatin	NOUN
admet-394	177	30	following	follow	VERB
admet-394	177	31	downregulation	downregulation	NOUN
admet-394	177	32	of	of	ADP
admet-394	177	33	oct-1	oct-1	ADJ
admet-394	177	34	.	.	PUNCT
admet-394	178	1	in	in	ADP
admet-394	178	2	contrast	contrast	NOUN
admet-394	178	3	,	,	PUNCT
admet-394	178	4	depletion	depletion	NOUN
admet-394	178	5	of	of	ADP
admet-394	178	6	oct-2	oct-2	NUM
admet-394	178	7	by	by	ADP
admet-394	178	8	rnai	rnai	PROPN
admet-394	178	9	in	in	ADP
admet-394	178	10	the	the	DET
admet-394	178	11	xpa-1	xpa-1	PUNCT
admet-394	178	12	mutant	mutant	ADJ
admet-394	178	13	animals	animal	NOUN
admet-394	178	14	suppressed	suppress	VERB
admet-394	178	15	the	the	DET
admet-394	178	16	high	high	ADJ
admet-394	178	17	level	level	NOUN
admet-394	178	18	of	of	ADP
admet-394	178	19	apoptotic	apoptotic	ADJ
admet-394	178	20	cells	cell	NOUN
admet-394	178	21	observed	observe	VERB
admet-394	178	22	in	in	ADP
admet-394	178	23	this	this	DET
admet-394	178	24	mutant	mutant	NOUN
admet-394	178	25	upon	upon	SCONJ
admet-394	178	26	exposure	exposure	NOUN
admet-394	178	27	to	to	ADP
admet-394	178	28	cisplatin	cisplatin	NOUN
admet-394	178	29	.	.	PUNCT
admet-394	179	1	these	these	DET
admet-394	179	2	data	datum	NOUN
admet-394	179	3	indicate	indicate	VERB
admet-394	179	4	that	that	SCONJ
admet-394	179	5	upregulation	upregulation	NOUN
admet-394	179	6	of	of	ADP
admet-394	179	7	oct-2	oct-2	NUM
admet-394	179	8	burdens	burden	NOUN
admet-394	179	9	the	the	DET
admet-394	179	10	xpa-1	xpa-1	PUNCT
admet-394	179	11	mutant	mutant	ADJ
admet-394	179	12	animals	animal	NOUN
admet-394	179	13	with	with	ADP
admet-394	179	14	cisplatin	cisplatin	NOUN
admet-394	179	15	-	-	PUNCT
admet-394	179	16	induced	induce	VERB
admet-394	179	17	dna	dna	PROPN
admet-394	179	18	lesions	lesion	NOUN
admet-394	179	19	leading	lead	VERB
admet-394	179	20	to	to	ADP
admet-394	179	21	the	the	DET
admet-394	179	22	enhancement	enhancement	NOUN
admet-394	179	23	of	of	ADP
admet-394	179	24	germ	germ	NOUN
admet-394	179	25	cell	cell	NOUN
admet-394	179	26	death	death	NOUN
admet-394	180	1	[	[	X
admet-394	180	2	51	51	NUM
admet-394	180	3	]	]	X
admet-394	181	1	[	[	X
admet-394	181	2	52	52	NUM
admet-394	181	3	]	]	PUNCT
admet-394	181	4	.	.	PUNCT
admet-394	182	1	thus	thus	ADV
admet-394	182	2	,	,	PUNCT
admet-394	182	3	the	the	DET
admet-394	182	4	current	current	ADJ
admet-394	182	5	studies	study	NOUN
admet-394	182	6	suggest	suggest	VERB
admet-394	182	7	that	that	SCONJ
admet-394	182	8	by	by	ADP
admet-394	182	9	combining	combine	VERB
admet-394	182	10	defects	defect	NOUN
admet-394	182	11	of	of	ADP
admet-394	182	12	various	various	ADJ
admet-394	182	13	dna	dna	PROPN
admet-394	182	14	repair	repair	NOUN
admet-394	182	15	pathways	pathway	NOUN
admet-394	182	16	with	with	ADP
admet-394	182	17	functional	functional	ADJ
admet-394	182	18	organic	organic	ADJ
admet-394	182	19	cation	cation	NOUN
admet-394	182	20	transporters	transporter	NOUN
admet-394	182	21	such	such	ADJ
admet-394	182	22	as	as	ADP
admet-394	182	23	oct-2	oct-2	NOUN
admet-394	182	24	,	,	PUNCT
admet-394	182	25	it	it	PRON
admet-394	182	26	is	be	AUX
admet-394	182	27	possible	possible	ADJ
admet-394	182	28	to	to	PART
admet-394	182	29	determine	determine	VERB
admet-394	182	30	whether	whether	SCONJ
admet-394	182	31	an	an	DET
admet-394	182	32	unknown	unknown	ADJ
admet-394	182	33	compound	compound	NOUN
admet-394	182	34	has	have	VERB
admet-394	182	35	genotoxic	genotoxic	ADJ
admet-394	182	36	effects	effect	NOUN
admet-394	182	37	and	and	CCONJ
admet-394	182	38	the	the	DET
admet-394	182	39	type	type	NOUN
admet-394	182	40	of	of	ADP
admet-394	182	41	lesions	lesion	NOUN
admet-394	182	42	it	it	PRON
admet-394	182	43	may	may	AUX
admet-394	182	44	create	create	VERB
admet-394	182	45	.	.	PUNCT
admet-394	183	1	oct-2	oct-2	VERB
admet-394	183	2	transports	transport	NOUN
admet-394	183	3	the	the	DET
admet-394	183	4	rad51	rad51	ADJ
admet-394	183	5	inhibitor	inhibitor	NOUN
admet-394	183	6	b02	b02	NOUN
admet-394	183	7	in	in	ADP
admet-394	183	8	addition	addition	NOUN
admet-394	183	9	to	to	ADP
admet-394	183	10	the	the	DET
admet-394	183	11	genotoxic	genotoxic	ADJ
admet-394	183	12	agents	agent	NOUN
admet-394	183	13	that	that	PRON
admet-394	183	14	docked	dock	VERB
admet-394	183	15	onto	onto	ADP
admet-394	183	16	oct-2	oct-2	NOUN
admet-394	183	17	,	,	PUNCT
admet-394	183	18	the	the	DET
admet-394	183	19	analyses	analysis	NOUN
admet-394	183	20	revealed	reveal	VERB
admet-394	183	21	that	that	SCONJ
admet-394	183	22	many	many	ADJ
admet-394	183	23	chemical	chemical	NOUN
admet-394	183	24	compounds	compound	NOUN
admet-394	183	25	such	such	ADJ
admet-394	183	26	as	as	ADP
admet-394	183	27	3	3	NUM
admet-394	183	28	-	-	PUNCT
admet-394	183	29	benzyl-2-[(e)-2	benzyl-2-[(e)-2	NOUN
admet-394	183	30	-	-	PUNCT
admet-394	183	31	pyridin-3	pyridin-3	NOUN
admet-394	183	32	-	-	PUNCT
admet-394	183	33	ylethenyl]quinazolin-4	ylethenyl]quinazolin-4	NOUN
admet-394	183	34	-	-	PUNCT
admet-394	183	35	one	one	NUM
admet-394	183	36	(	(	PUNCT
admet-394	183	37	b02	b02	NOUN
admet-394	183	38	,	,	PUNCT
admet-394	183	39	cid	cid	NOUN
admet-394	183	40	:	:	PUNCT
admet-394	183	41	5738263	5738263	NUM
admet-394	183	42	)	)	PUNCT
admet-394	183	43	,	,	PUNCT
admet-394	183	44	referred	refer	VERB
admet-394	183	45	to	to	ADP
admet-394	183	46	as	as	ADP
admet-394	183	47	b02	b02	PROPN
admet-394	183	48	,	,	PUNCT
admet-394	183	49	has	have	VERB
admet-394	183	50	the	the	DET
admet-394	183	51	ability	ability	NOUN
admet-394	183	52	to	to	PART
admet-394	183	53	robustly	robustly	ADV
admet-394	183	54	interact	interact	VERB
admet-394	183	55	with	with	ADP
admet-394	183	56	oct-2	oct-2	NOUN
admet-394	183	57	,	,	PUNCT
admet-394	183	58	and	and	CCONJ
admet-394	183	59	not	not	PART
admet-394	183	60	oct-1	oct-1	PRON
admet-394	183	61	.	.	PUNCT
admet-394	183	62	in	in	ADP
admet-394	183	63	human	human	ADJ
admet-394	183	64	cells	cell	NOUN
admet-394	183	65	,	,	PUNCT
admet-394	183	66	b02	b02	PROPN
admet-394	183	67	has	have	AUX
admet-394	183	68	been	be	AUX
admet-394	183	69	shown	show	VERB
admet-394	183	70	to	to	PART
admet-394	183	71	interfere	interfere	VERB
admet-394	183	72	with	with	ADP
admet-394	183	73	the	the	DET
admet-394	183	74	dna	dna	PROPN
admet-394	183	75	strand	strand	NOUN
admet-394	183	76	exchange	exchange	NOUN
admet-394	183	77	and	and	CCONJ
admet-394	183	78	the	the	DET
admet-394	183	79	nuclear	nuclear	ADJ
admet-394	183	80	foci	focus	NOUN
admet-394	183	81	formation	formation	NOUN
admet-394	183	82	catalyzed	catalyze	VERB
admet-394	183	83	by	by	ADP
admet-394	183	84	the	the	DET
admet-394	183	85	dna	dna	PROPN
admet-394	183	86	repair	repair	NOUN
admet-394	183	87	protein	protein	NOUN
admet-394	183	88	rad51	rad51	NOUN
admet-394	183	89	.	.	PUNCT
admet-394	184	1	rad51	rad51	PROPN
admet-394	184	2	is	be	AUX
admet-394	184	3	required	require	VERB
admet-394	184	4	to	to	PART
admet-394	184	5	repair	repair	VERB
admet-394	184	6	dna	dna	NOUN
admet-394	184	7	double	double	ADJ
admet-394	184	8	strand	strand	NOUN
admet-394	184	9	breaks	break	NOUN
admet-394	184	10	during	during	ADP
admet-394	184	11	meiosis	meiosis	NOUN
admet-394	184	12	and	and	CCONJ
admet-394	184	13	in	in	ADP
admet-394	184	14	response	response	NOUN
admet-394	184	15	to	to	ADP
admet-394	184	16	dna	dna	PROPN
admet-394	184	17	damaging	damaging	ADJ
admet-394	184	18	agents	agent	NOUN
admet-394	185	1	[	[	X
admet-394	185	2	53	53	NUM
admet-394	185	3	-	-	SYM
admet-394	185	4	55	55	NUM
admet-394	185	5	]	]	PUNCT
admet-394	185	6	.	.	PUNCT
admet-394	186	1	examination	examination	NOUN
admet-394	186	2	of	of	ADP
admet-394	186	3	the	the	DET
admet-394	186	4	pharmacological	pharmacological	ADJ
admet-394	186	5	effect	effect	NOUN
admet-394	186	6	of	of	ADP
admet-394	186	7	b02	b02	PROPN
admet-394	186	8	in	in	ADP
admet-394	186	9	c.	c.	PROPN
admet-394	186	10	elegans	elegans	PROPN
admet-394	186	11	revealed	reveal	VERB
admet-394	186	12	that	that	SCONJ
admet-394	186	13	this	this	DET
admet-394	186	14	inhibitor	inhibitor	NOUN
admet-394	186	15	caused	cause	VERB
admet-394	186	16	sterility	sterility	NOUN
admet-394	186	17	in	in	ADP
admet-394	186	18	the	the	DET
admet-394	186	19	oct-1	oct-1	ADV
admet-394	186	20	null	null	ADJ
admet-394	186	21	mutant	mutant	NOUN
admet-394	186	22	.	.	PUNCT
admet-394	187	1	this	this	PRON
admet-394	187	2	is	be	AUX
admet-394	187	3	marked	mark	VERB
admet-394	187	4	by	by	ADP
admet-394	187	5	the	the	DET
admet-394	187	6	production	production	NOUN
admet-394	187	7	of	of	ADP
admet-394	187	8	inviable	inviable	ADJ
admet-394	187	9	embryos	embryo	NOUN
admet-394	187	10	and	and	CCONJ
admet-394	187	11	a	a	DET
admet-394	187	12	decrease	decrease	NOUN
admet-394	187	13	in	in	ADP
admet-394	187	14	the	the	DET
admet-394	187	15	number	number	NOUN
admet-394	187	16	of	of	ADP
admet-394	187	17	viable	viable	ADJ
admet-394	187	18	animals	animal	NOUN
admet-394	187	19	,	,	PUNCT
admet-394	187	20	phenotypes	phenotype	NOUN
admet-394	187	21	that	that	PRON
admet-394	187	22	mimic	mimic	VERB
admet-394	187	23	those	those	PRON
admet-394	187	24	of	of	ADP
admet-394	187	25	the	the	PRON
admet-394	187	26	rad-51	rad-51	NUM
admet-394	187	27	homozygotes	homozygote	NOUN
admet-394	187	28	[	[	X
admet-394	187	29	56	56	NUM
admet-394	187	30	]	]	PUNCT
admet-394	187	31	.	.	PUNCT
admet-394	188	1	as	as	SCONJ
admet-394	188	2	predicted	predict	VERB
admet-394	188	3	from	from	ADP
admet-394	188	4	the	the	DET
admet-394	188	5	model	model	NOUN
admet-394	188	6	,	,	PUNCT
admet-394	188	7	downregulation	downregulation	NOUN
admet-394	188	8	of	of	ADP
admet-394	188	9	oct-2	oct-2	NUM
admet-394	188	10	in	in	ADP
admet-394	188	11	the	the	DET
admet-394	188	12	oct-1	oct-1	ADV
admet-394	188	13	null	null	ADJ
admet-394	188	14	mutant	mutant	NOUN
admet-394	188	15	prevented	prevent	VERB
admet-394	188	16	the	the	DET
admet-394	188	17	b02	b02	PROPN
admet-394	188	18	ligand	ligand	NOUN
admet-394	188	19	from	from	ADP
admet-394	188	20	causing	cause	VERB
admet-394	188	21	sterility	sterility	NOUN
admet-394	188	22	[	[	X
admet-394	188	23	33	33	NUM
admet-394	188	24	]	]	PUNCT
admet-394	188	25	.	.	PUNCT
admet-394	189	1	under	under	ADP
admet-394	189	2	these	these	DET
admet-394	189	3	conditions	condition	NOUN
admet-394	189	4	,	,	PUNCT
admet-394	189	5	the	the	DET
admet-394	189	6	oct-1	oct-1	ADV
admet-394	189	7	null	null	ADJ
admet-394	189	8	mutant	mutant	NOUN
admet-394	189	9	produced	produce	VERB
admet-394	189	10	viable	viable	ADJ
admet-394	189	11	embryos	embryo	NOUN
admet-394	189	12	that	that	PRON
admet-394	189	13	resulted	result	VERB
admet-394	189	14	in	in	ADP
admet-394	189	15	nearly	nearly	ADV
admet-394	189	16	normal	normal	ADJ
admet-394	189	17	levels	level	NOUN
admet-394	189	18	of	of	ADP
admet-394	189	19	viable	viable	ADJ
admet-394	189	20	animals	animal	NOUN
admet-394	189	21	[	[	X
admet-394	189	22	33	33	NUM
admet-394	189	23	]	]	PUNCT
admet-394	189	24	.	.	PUNCT
admet-394	190	1	from	from	ADP
admet-394	190	2	these	these	DET
admet-394	190	3	data	datum	NOUN
admet-394	190	4	,	,	PUNCT
admet-394	190	5	it	it	PRON
admet-394	190	6	is	be	AUX
admet-394	190	7	clear	clear	ADJ
admet-394	190	8	that	that	SCONJ
admet-394	190	9	b02	b02	PROPN
admet-394	190	10	can	can	AUX
admet-394	190	11	also	also	ADV
admet-394	190	12	inhibit	inhibit	VERB
admet-394	190	13	rad-51	rad-51	ADP
admet-394	190	14	function	function	NOUN
admet-394	190	15	in	in	ADP
admet-394	190	16	c.	c.	PROPN
admet-394	190	17	elegans	elegan	NOUN
admet-394	190	18	and	and	CCONJ
admet-394	190	19	this	this	PRON
admet-394	190	20	depends	depend	VERB
admet-394	190	21	on	on	ADP
admet-394	190	22	the	the	DET
admet-394	190	23	function	function	NOUN
admet-394	190	24	of	of	ADP
admet-394	190	25	the	the	DET
admet-394	190	26	oct-2	oct-2	NOUN
admet-394	190	27	uptake	uptake	ADJ
admet-394	190	28	transporter	transporter	NOUN
admet-394	190	29	[	[	X
admet-394	190	30	33	33	NUM
admet-394	190	31	]	]	PUNCT
admet-394	190	32	.	.	PUNCT
admet-394	191	1	thus	thus	ADV
admet-394	191	2	,	,	PUNCT
admet-394	191	3	the	the	DET
admet-394	191	4	docking	docking	NOUN
admet-394	191	5	scores	score	NOUN
admet-394	191	6	of	of	ADP
admet-394	191	7	ligands	ligand	NOUN
admet-394	191	8	and	and	CCONJ
admet-394	191	9	proper	proper	ADJ
admet-394	191	10	readouts	readout	NOUN
admet-394	191	11	from	from	ADP
admet-394	191	12	the	the	DET
admet-394	191	13	targeted	target	VERB
admet-394	191	14	pathway	pathway	NOUN
admet-394	191	15	provide	provide	VERB
admet-394	191	16	valuable	valuable	ADJ
admet-394	191	17	tools	tool	NOUN
admet-394	191	18	to	to	PART
admet-394	191	19	monitor	monitor	VERB
admet-394	191	20	transporter	transporter	NOUN
admet-394	191	21	-	-	PUNCT
admet-394	191	22	mediated	mediate	VERB
admet-394	191	23	drug	drug	NOUN
admet-394	191	24	uptake	uptake	NOUN
admet-394	191	25	into	into	ADP
admet-394	191	26	c.	c.	PROPN
admet-394	191	27	elegans	elegans	PROPN
admet-394	191	28	.	.	PUNCT
admet-394	192	1	perspectives	perspective	NOUN
admet-394	192	2	there	there	PRON
admet-394	192	3	is	be	VERB
admet-394	192	4	no	no	DET
admet-394	192	5	evidence	evidence	NOUN
admet-394	192	6	yet	yet	ADV
admet-394	192	7	that	that	SCONJ
admet-394	192	8	oct-1	oct-1	ADV
admet-394	192	9	can	can	AUX
admet-394	192	10	function	function	VERB
admet-394	192	11	as	as	ADP
admet-394	192	12	an	an	DET
admet-394	192	13	uptake	uptake	ADJ
admet-394	192	14	transporter	transporter	NOUN
admet-394	192	15	in	in	ADP
admet-394	192	16	c.	c.	NOUN
admet-394	192	17	elegans	elegan	NOUN
admet-394	192	18	,	,	PUNCT
admet-394	192	19	although	although	SCONJ
admet-394	192	20	when	when	SCONJ
admet-394	192	21	expressed	express	VERB
admet-394	192	22	in	in	ADP
admet-394	192	23	two	two	NUM
admet-394	192	24	different	different	ADJ
admet-394	192	25	heterologous	heterologous	ADJ
admet-394	192	26	model	model	NOUN
admet-394	192	27	system	system	NOUN
admet-394	192	28	,	,	PUNCT
admet-394	192	29	human	human	NOUN
admet-394	192	30	and	and	CCONJ
admet-394	192	31	yeast	yeast	NOUN
admet-394	192	32	cells	cell	NOUN
admet-394	192	33	,	,	PUNCT
admet-394	192	34	it	it	PRON
admet-394	192	35	can	can	AUX
admet-394	192	36	stimulate	stimulate	VERB
admet-394	192	37	uptake	uptake	NOUN
admet-394	192	38	of	of	ADP
admet-394	192	39	tetraethylammonia	tetraethylammonia	NOUN
admet-394	192	40	and	and	CCONJ
admet-394	192	41	doxorubicin	doxorubicin	PROPN
admet-394	192	42	,	,	PUNCT
admet-394	192	43	respectively	respectively	ADV
admet-394	192	44	[	[	X
admet-394	192	45	18	18	NUM
admet-394	192	46	,	,	PUNCT
admet-394	192	47	31	31	NUM
admet-394	192	48	]	]	PUNCT
admet-394	192	49	.	.	PUNCT
admet-394	193	1	while	while	SCONJ
admet-394	193	2	in	in	ADP
admet-394	193	3	human	human	ADJ
admet-394	193	4	cells	cell	NOUN
admet-394	193	5	downregulation	downregulation	NOUN
admet-394	193	6	of	of	ADP
admet-394	193	7	oct1	oct1	NOUN
admet-394	193	8	caused	cause	VERB
admet-394	193	9	resistance	resistance	NOUN
admet-394	193	10	to	to	ADP
admet-394	193	11	anthracyclines	anthracycline	NOUN
admet-394	193	12	,	,	PUNCT
admet-394	193	13	this	this	PRON
admet-394	193	14	was	be	AUX
admet-394	193	15	not	not	PART
admet-394	193	16	the	the	DET
admet-394	193	17	case	case	NOUN
admet-394	193	18	in	in	ADP
admet-394	193	19	c.	c.	PROPN
admet-394	193	20	elegans	elegan	NOUN
admet-394	193	21	devoid	devoid	ADJ
admet-394	193	22	of	of	ADP
admet-394	193	23	oct-1	oct-1	PRON
admet-394	193	24	,	,	PUNCT
admet-394	193	25	thus	thus	ADV
admet-394	193	26	a	a	DET
admet-394	193	27	direct	direct	ADJ
admet-394	193	28	role	role	NOUN
admet-394	193	29	for	for	ADP
admet-394	193	30	oct-1	oct-1	ADV
admet-394	193	31	in	in	ADP
admet-394	193	32	the	the	DET
admet-394	193	33	uptake	uptake	NOUN
admet-394	193	34	of	of	ADP
admet-394	193	35	anthracyclines	anthracycline	NOUN
admet-394	193	36	can	can	AUX
admet-394	193	37	be	be	AUX
admet-394	193	38	excluded	exclude	VERB
admet-394	193	39	.	.	PUNCT
admet-394	194	1	whether	whether	SCONJ
admet-394	194	2	oct-1	oct-1	PRON
admet-394	194	3	acts	act	VERB
admet-394	194	4	as	as	ADP
admet-394	194	5	an	an	DET
admet-394	194	6	uptake	uptake	ADJ
admet-394	194	7	transporter	transporter	NOUN
admet-394	194	8	dindial	dindial	ADJ
admet-394	194	9	ramotar	ramotar	PROPN
admet-394	194	10	admet	admet	PROPN
admet-394	194	11	&	&	CCONJ
admet-394	194	12	dmpk	dmpk	PROPN
admet-394	194	13	5(3	5(3	NUM
admet-394	194	14	)	)	PUNCT
admet-394	194	15	(	(	PUNCT
admet-394	194	16	2017	2017	NUM
admet-394	194	17	)	)	PUNCT
admet-394	194	18	146	146	NUM
admet-394	194	19	-	-	SYM
admet-394	194	20	158	158	NUM
admet-394	194	21	154	154	NUM
admet-394	194	22	for	for	ADP
admet-394	194	23	selective	selective	ADJ
admet-394	194	24	drugs	drug	NOUN
admet-394	194	25	remains	remain	VERB
admet-394	194	26	a	a	DET
admet-394	194	27	possibility	possibility	NOUN
admet-394	194	28	.	.	PUNCT
admet-394	195	1	nonetheless	nonetheless	ADV
admet-394	195	2	,	,	PUNCT
admet-394	195	3	in	in	ADP
admet-394	195	4	c.	c.	PROPN
admet-394	195	5	elegans	elegan	NOUN
admet-394	195	6	oct-1	oct-1	PUNCT
admet-394	195	7	has	have	VERB
admet-394	195	8	a	a	DET
admet-394	195	9	role	role	NOUN
admet-394	195	10	in	in	ADP
admet-394	195	11	exerting	exert	VERB
admet-394	195	12	control	control	NOUN
admet-394	195	13	on	on	ADP
admet-394	195	14	oct-2	oct-2	NOUN
admet-394	195	15	expression	expression	NOUN
admet-394	195	16	,	,	PUNCT
admet-394	195	17	and	and	CCONJ
admet-394	195	18	it	it	PRON
admet-394	195	19	is	be	AUX
admet-394	195	20	oct-2	oct-2	NOUN
admet-394	195	21	that	that	PRON
admet-394	195	22	is	be	AUX
admet-394	195	23	primarily	primarily	ADV
admet-394	195	24	involved	involve	VERB
admet-394	195	25	in	in	ADP
admet-394	195	26	the	the	DET
admet-394	195	27	uptake	uptake	NOUN
admet-394	195	28	of	of	ADP
admet-394	195	29	doxorubicin	doxorubicin	PROPN
admet-394	195	30	and	and	CCONJ
admet-394	195	31	other	other	ADJ
admet-394	195	32	substrates	substrate	NOUN
admet-394	195	33	.	.	PUNCT
admet-394	196	1	we	we	PRON
admet-394	196	2	believe	believe	VERB
admet-394	196	3	that	that	SCONJ
admet-394	196	4	oct-2	oct-2	VERB
admet-394	196	5	has	have	VERB
admet-394	196	6	a	a	DET
admet-394	196	7	broad	broad	ADJ
admet-394	196	8	specificity	specificity	NOUN
admet-394	196	9	and	and	CCONJ
admet-394	196	10	can	can	AUX
admet-394	196	11	transport	transport	VERB
admet-394	196	12	various	various	ADJ
admet-394	196	13	substrates	substrate	NOUN
admet-394	196	14	,	,	PUNCT
admet-394	196	15	including	include	VERB
admet-394	196	16	toxic	toxic	ADJ
admet-394	196	17	environmental	environmental	ADJ
admet-394	196	18	compounds	compound	NOUN
admet-394	196	19	,	,	PUNCT
admet-394	196	20	from	from	ADP
admet-394	196	21	the	the	DET
admet-394	196	22	pharynx	pharynx	NOUN
admet-394	196	23	into	into	ADP
admet-394	196	24	the	the	DET
admet-394	196	25	intestine	intestine	NOUN
admet-394	196	26	(	(	PUNCT
admet-394	196	27	fig	fig	NOUN
admet-394	196	28	.	.	NOUN
admet-394	197	1	1	1	NUM
admet-394	197	2	)	)	PUNCT
admet-394	197	3	.	.	PUNCT
admet-394	198	1	the	the	DET
admet-394	198	2	oct-2	oct-2	PROPN
admet-394	198	3	in	in	ADP
admet-394	198	4	the	the	DET
admet-394	198	5	intestine	intestine	NOUN
admet-394	198	6	then	then	ADV
admet-394	198	7	transports	transport	VERB
admet-394	198	8	the	the	DET
admet-394	198	9	substrates	substrate	NOUN
admet-394	198	10	into	into	ADP
admet-394	198	11	the	the	DET
admet-394	198	12	vicinity	vicinity	NOUN
admet-394	198	13	of	of	ADP
admet-394	198	14	the	the	DET
admet-394	198	15	oocytes	oocyte	NOUN
admet-394	198	16	and	and	CCONJ
admet-394	198	17	embryos	embryo	NOUN
admet-394	198	18	,	,	PUNCT
admet-394	198	19	which	which	PRON
admet-394	198	20	are	be	AUX
admet-394	198	21	also	also	ADV
admet-394	198	22	equipped	equip	VERB
admet-394	198	23	with	with	ADP
admet-394	198	24	the	the	DET
admet-394	198	25	oct-2	oct-2	NOUN
admet-394	198	26	transporter	transporter	NOUN
admet-394	198	27	(	(	PUNCT
admet-394	198	28	fig	fig	NOUN
admet-394	198	29	.	.	PUNCT
admet-394	198	30	1	1	NUM
admet-394	198	31	)	)	PUNCT
admet-394	198	32	.	.	PUNCT
admet-394	199	1	thus	thus	ADV
admet-394	199	2	,	,	PUNCT
admet-394	199	3	removal	removal	NOUN
admet-394	199	4	of	of	ADP
admet-394	199	5	oct-2	oct-2	NUM
admet-394	199	6	stands	stand	VERB
admet-394	199	7	to	to	PART
admet-394	199	8	protect	protect	VERB
admet-394	199	9	the	the	DET
admet-394	199	10	animal	animal	NOUN
admet-394	199	11	from	from	ADP
admet-394	199	12	germ	germ	NOUN
admet-394	199	13	cell	cell	NOUN
admet-394	199	14	death	death	NOUN
admet-394	199	15	induced	induce	VERB
admet-394	199	16	by	by	ADP
admet-394	199	17	environmental	environmental	ADJ
admet-394	199	18	and	and	CCONJ
admet-394	199	19	chemical	chemical	ADJ
admet-394	199	20	toxicants	toxicant	NOUN
admet-394	199	21	.	.	PUNCT
admet-394	200	1	the	the	DET
admet-394	200	2	data	datum	NOUN
admet-394	200	3	obtained	obtain	VERB
admet-394	200	4	so	so	ADV
admet-394	200	5	far	far	ADV
admet-394	200	6	underscore	underscore	VERB
admet-394	200	7	the	the	DET
admet-394	200	8	importance	importance	NOUN
admet-394	200	9	of	of	ADP
admet-394	200	10	uptake	uptake	ADJ
admet-394	200	11	transporters	transporter	NOUN
admet-394	200	12	in	in	ADP
admet-394	200	13	regulating	regulate	VERB
admet-394	200	14	the	the	DET
admet-394	200	15	entry	entry	NOUN
admet-394	200	16	of	of	ADP
admet-394	200	17	drugs	drug	NOUN
admet-394	200	18	into	into	ADP
admet-394	200	19	cells	cell	NOUN
admet-394	200	20	and	and	CCONJ
admet-394	200	21	raise	raise	VERB
admet-394	200	22	the	the	DET
admet-394	200	23	possibility	possibility	NOUN
admet-394	200	24	that	that	SCONJ
admet-394	200	25	(	(	PUNCT
admet-394	200	26	i	i	NOUN
admet-394	200	27	)	)	PUNCT
admet-394	200	28	the	the	DET
admet-394	200	29	drugresistance	drugresistance	NOUN
admet-394	200	30	and	and	CCONJ
admet-394	200	31	-sensitivity	-sensitivity	NOUN
admet-394	200	32	exhibited	exhibit	VERB
admet-394	200	33	by	by	ADP
admet-394	200	34	cancer	cancer	NOUN
admet-394	200	35	patients	patient	NOUN
admet-394	200	36	could	could	AUX
admet-394	200	37	be	be	AUX
admet-394	200	38	governed	govern	VERB
admet-394	200	39	at	at	ADP
admet-394	200	40	the	the	DET
admet-394	200	41	level	level	NOUN
admet-394	200	42	of	of	ADP
admet-394	200	43	the	the	DET
admet-394	200	44	uptake	uptake	ADJ
admet-394	200	45	transporters	transporter	NOUN
admet-394	200	46	and	and	CCONJ
admet-394	200	47	(	(	PUNCT
admet-394	200	48	ii	ii	NOUN
admet-394	200	49	)	)	PUNCT
admet-394	200	50	the	the	DET
admet-394	200	51	absence	absence	NOUN
admet-394	200	52	of	of	ADP
admet-394	200	53	one	one	NUM
admet-394	200	54	transporter	transporter	NOUN
admet-394	200	55	could	could	AUX
admet-394	200	56	greatly	greatly	ADV
admet-394	200	57	impact	impact	VERB
admet-394	200	58	the	the	DET
admet-394	200	59	function	function	NOUN
admet-394	200	60	of	of	ADP
admet-394	200	61	another	another	PRON
admet-394	200	62	.	.	PUNCT
admet-394	201	1	figure	figure	NOUN
admet-394	201	2	1	1	NUM
admet-394	201	3	.	.	PUNCT
admet-394	202	1	illustration	illustration	NOUN
admet-394	202	2	of	of	ADP
admet-394	202	3	key	key	ADJ
admet-394	202	4	features	feature	NOUN
admet-394	202	5	of	of	ADP
admet-394	202	6	an	an	DET
admet-394	202	7	adult	adult	NOUN
admet-394	202	8	c.	c.	NOUN
admet-394	202	9	elegans	elegan	NOUN
admet-394	202	10	hermaphrodite	hermaphrodite	PROPN
admet-394	202	11	.	.	PUNCT
admet-394	203	1	the	the	DET
admet-394	203	2	blue	blue	ADJ
admet-394	203	3	squiggly	squiggly	ADJ
admet-394	203	4	line	line	NOUN
admet-394	203	5	represents	represent	VERB
admet-394	203	6	the	the	DET
admet-394	203	7	putative	putative	ADJ
admet-394	203	8	location	location	NOUN
admet-394	203	9	of	of	ADP
admet-394	203	10	oct-1	oct-1	ADJ
admet-394	203	11	transporter	transporter	NOUN
admet-394	203	12	,	,	PUNCT
admet-394	203	13	while	while	SCONJ
admet-394	203	14	the	the	DET
admet-394	203	15	red	red	ADJ
admet-394	203	16	squiggly	squiggly	ADV
admet-394	203	17	line	line	NOUN
admet-394	203	18	and	and	CCONJ
admet-394	203	19	short	short	ADJ
admet-394	203	20	vertical	vertical	ADJ
admet-394	203	21	red	red	ADJ
admet-394	203	22	bar	bar	PROPN
admet-394	203	23	represent	represent	VERB
admet-394	203	24	the	the	DET
admet-394	203	25	putative	putative	ADJ
admet-394	203	26	locations	location	NOUN
admet-394	203	27	of	of	ADP
admet-394	203	28	oct-2	oct-2	NOUN
admet-394	203	29	transporter	transporter	NOUN
admet-394	203	30	on	on	ADP
admet-394	203	31	the	the	DET
admet-394	203	32	pharynx	pharynx	NOUN
admet-394	203	33	,	,	PUNCT
admet-394	203	34	intestine	intestine	NOUN
admet-394	203	35	,	,	PUNCT
admet-394	203	36	oocytes	oocyte	NOUN
admet-394	203	37	and	and	CCONJ
admet-394	203	38	embryos	embryo	NOUN
admet-394	203	39	.	.	PUNCT
admet-394	204	1	the	the	DET
admet-394	204	2	studies	study	NOUN
admet-394	204	3	to	to	ADP
admet-394	204	4	date	date	NOUN
admet-394	204	5	also	also	ADV
admet-394	204	6	raised	raise	VERB
admet-394	204	7	additional	additional	ADJ
admet-394	204	8	concern	concern	NOUN
admet-394	204	9	and	and	CCONJ
admet-394	204	10	that	that	PRON
admet-394	204	11	is	be	AUX
admet-394	204	12	whether	whether	SCONJ
admet-394	204	13	the	the	DET
admet-394	204	14	upregulated	upregulated	ADJ
admet-394	204	15	oct-2	oct-2	PUNCT
admet-394	204	16	transporter	transporter	NOUN
admet-394	204	17	can	can	AUX
admet-394	204	18	import	import	VERB
admet-394	204	19	compounds	compound	NOUN
admet-394	204	20	from	from	ADP
admet-394	204	21	the	the	DET
admet-394	204	22	growth	growth	NOUN
admet-394	204	23	media	medium	NOUN
admet-394	204	24	that	that	PRON
admet-394	204	25	cause	cause	VERB
admet-394	204	26	dna	dna	NOUN
admet-394	204	27	damage	damage	NOUN
admet-394	204	28	and	and	CCONJ
admet-394	204	29	ultimately	ultimately	ADV
admet-394	204	30	leading	lead	VERB
admet-394	204	31	to	to	ADP
admet-394	204	32	genomic	genomic	ADJ
admet-394	204	33	instability	instability	NOUN
admet-394	204	34	over	over	ADP
admet-394	204	35	time	time	NOUN
admet-394	204	36	.	.	PUNCT
admet-394	205	1	if	if	SCONJ
admet-394	205	2	this	this	PRON
admet-394	205	3	were	be	AUX
admet-394	205	4	the	the	DET
admet-394	205	5	case	case	NOUN
admet-394	205	6	,	,	PUNCT
admet-394	205	7	then	then	ADV
admet-394	205	8	individuals	individual	NOUN
admet-394	205	9	with	with	ADP
admet-394	205	10	deregulated	deregulated	ADJ
admet-394	205	11	uptake	uptake	ADJ
admet-394	205	12	transporters	transporter	NOUN
admet-394	205	13	are	be	AUX
admet-394	205	14	likely	likely	ADJ
admet-394	205	15	at	at	ADP
admet-394	205	16	increased	increase	VERB
admet-394	205	17	risk	risk	NOUN
admet-394	205	18	of	of	ADP
admet-394	205	19	being	be	AUX
admet-394	205	20	bombarded	bombard	VERB
admet-394	205	21	with	with	ADP
admet-394	205	22	genotoxic	genotoxic	ADJ
admet-394	205	23	compounds	compound	NOUN
admet-394	205	24	that	that	PRON
admet-394	205	25	could	could	AUX
admet-394	205	26	lead	lead	VERB
admet-394	205	27	to	to	ADP
admet-394	205	28	various	various	ADJ
admet-394	205	29	diseases	disease	NOUN
admet-394	205	30	such	such	ADJ
admet-394	205	31	as	as	ADP
admet-394	205	32	cancers	cancer	NOUN
admet-394	205	33	.	.	PUNCT
admet-394	206	1	in	in	ADP
admet-394	206	2	fact	fact	NOUN
admet-394	206	3	,	,	PUNCT
admet-394	206	4	preliminary	preliminary	ADJ
admet-394	206	5	data	datum	NOUN
admet-394	206	6	revealed	reveal	VERB
admet-394	206	7	that	that	SCONJ
admet-394	206	8	the	the	DET
admet-394	206	9	upregulation	upregulation	NOUN
admet-394	206	10	of	of	ADP
admet-394	206	11	oct-2	oct-2	NUM
admet-394	206	12	,	,	PUNCT
admet-394	206	13	via	via	ADP
admet-394	206	14	rnai	rnai	NOUN
admet-394	206	15	downregulation	downregulation	NOUN
admet-394	206	16	of	of	ADP
admet-394	206	17	oct-1	oct-1	ADV
admet-394	206	18	,	,	PUNCT
admet-394	206	19	resulted	result	VERB
admet-394	206	20	in	in	ADP
admet-394	206	21	at	at	ADV
admet-394	206	22	least	least	ADJ
admet-394	206	23	a	a	DET
admet-394	206	24	two	two	NUM
admet-394	206	25	-	-	ADJ
admet-394	206	26	fold	fold	ADJ
admet-394	206	27	increase	increase	NOUN
admet-394	206	28	in	in	ADP
admet-394	206	29	spontaneous	spontaneous	ADJ
admet-394	206	30	mutations	mutation	NOUN
admet-394	206	31	in	in	ADP
admet-394	206	32	a	a	DET
admet-394	206	33	c.	c.	NOUN
admet-394	206	34	elegans	elegan	NOUN
admet-394	206	35	strain	strain	VERB
admet-394	206	36	designed	design	VERB
admet-394	206	37	to	to	PART
admet-394	206	38	monitor	monitor	VERB
admet-394	206	39	frame	frame	NOUN
admet-394	206	40	shift	shift	NOUN
admet-394	206	41	mutations	mutation	NOUN
admet-394	206	42	at	at	ADP
admet-394	206	43	the	the	DET
admet-394	206	44	lacz	lacz	NOUN
admet-394	206	45	reporter	reporter	NOUN
admet-394	206	46	gene	gene	NOUN
admet-394	206	47	[	[	X
admet-394	206	48	57	57	NUM
admet-394	206	49	]	]	PUNCT
admet-394	206	50	.	.	PUNCT
admet-394	207	1	the	the	DET
admet-394	207	2	downregulation	downregulation	NOUN
admet-394	207	3	of	of	ADP
admet-394	207	4	oct-1	oct-1	ADV
admet-394	207	5	leading	lead	VERB
admet-394	207	6	to	to	ADP
admet-394	207	7	the	the	DET
admet-394	207	8	upregulation	upregulation	NOUN
admet-394	207	9	of	of	ADP
admet-394	207	10	oct-2	oct-2	NUM
admet-394	207	11	was	be	AUX
admet-394	207	12	an	an	DET
admet-394	207	13	unexpected	unexpected	ADJ
admet-394	207	14	finding	finding	NOUN
admet-394	207	15	,	,	PUNCT
admet-394	207	16	and	and	CCONJ
admet-394	207	17	provides	provide	VERB
admet-394	207	18	a	a	DET
admet-394	207	19	compelling	compelling	ADJ
admet-394	207	20	argument	argument	NOUN
admet-394	207	21	that	that	SCONJ
admet-394	207	22	the	the	DET
admet-394	207	23	animal	animal	NOUN
admet-394	207	24	has	have	AUX
admet-394	207	25	evolved	evolve	VERB
admet-394	207	26	tight	tight	ADJ
admet-394	207	27	regulation	regulation	NOUN
admet-394	207	28	of	of	ADP
admet-394	207	29	oct-2	oct-2	NUM
admet-394	207	30	presumably	presumably	ADV
admet-394	207	31	to	to	PART
admet-394	207	32	control	control	VERB
admet-394	207	33	uptake	uptake	ADJ
admet-394	207	34	of	of	ADP
admet-394	207	35	unwanted	unwanted	ADJ
admet-394	207	36	compounds	compound	NOUN
admet-394	207	37	.	.	PUNCT
admet-394	208	1	oct-1	oct-1	PUNCT
admet-394	208	2	could	could	AUX
admet-394	208	3	perform	perform	VERB
admet-394	208	4	a	a	DET
admet-394	208	5	function	function	NOUN
admet-394	208	6	as	as	ADP
admet-394	208	7	a	a	DET
admet-394	208	8	surface	surface	NOUN
admet-394	208	9	sensor	sensor	NOUN
admet-394	208	10	that	that	PRON
admet-394	208	11	acts	act	VERB
admet-394	208	12	as	as	ADP
admet-394	208	13	non	non	ADJ
admet-394	208	14	-	-	ADJ
admet-394	208	15	transporting	transporting	ADJ
admet-394	208	16	transceptors	transceptor	NOUN
admet-394	208	17	by	by	ADP
admet-394	208	18	sensing	sense	VERB
admet-394	208	19	the	the	DET
admet-394	208	20	availability	availability	NOUN
admet-394	208	21	of	of	ADP
admet-394	208	22	nutrients	nutrient	NOUN
admet-394	208	23	and	and	CCONJ
admet-394	208	24	signaling	signal	VERB
admet-394	208	25	the	the	DET
admet-394	208	26	regulation	regulation	NOUN
admet-394	208	27	of	of	ADP
admet-394	208	28	downstream	downstream	ADJ
admet-394	208	29	plasma	plasma	NOUN
admet-394	208	30	membrane	membrane	NOUN
admet-394	208	31	transporters	transporter	NOUN
admet-394	208	32	[	[	X
admet-394	208	33	32	32	NUM
admet-394	208	34	,	,	PUNCT
admet-394	208	35	58	58	NUM
admet-394	208	36	]	]	PUNCT
admet-394	208	37	.	.	PUNCT
admet-394	209	1	thus	thus	ADV
admet-394	209	2	,	,	PUNCT
admet-394	209	3	when	when	SCONJ
admet-394	209	4	nutrients	nutrient	NOUN
admet-394	209	5	are	be	AUX
admet-394	209	6	scarce	scarce	ADJ
admet-394	209	7	,	,	PUNCT
admet-394	209	8	oct-1	oct-1	NUM
admet-394	209	9	might	might	AUX
admet-394	209	10	serve	serve	VERB
admet-394	209	11	as	as	ADP
admet-394	209	12	a	a	DET
admet-394	209	13	sensor	sensor	NOUN
admet-394	209	14	to	to	PART
admet-394	209	15	promote	promote	VERB
admet-394	209	16	the	the	DET
admet-394	209	17	upregulation	upregulation	NOUN
admet-394	209	18	of	of	ADP
admet-394	209	19	oct-2	oct-2	PRON
admet-394	209	20	to	to	PART
admet-394	209	21	scavenge	scavenge	VERB
admet-394	209	22	the	the	DET
admet-394	209	23	limited	limited	ADJ
admet-394	209	24	resources	resource	NOUN
admet-394	209	25	,	,	PUNCT
admet-394	209	26	but	but	CCONJ
admet-394	209	27	sustain	sustain	VERB
admet-394	209	28	basal	basal	ADJ
admet-394	209	29	expression	expression	NOUN
admet-394	209	30	of	of	ADP
admet-394	209	31	oct-2	oct-2	PRON
admet-394	209	32	when	when	SCONJ
admet-394	209	33	nutrients	nutrient	NOUN
admet-394	209	34	are	be	AUX
admet-394	209	35	in	in	ADP
admet-394	209	36	surplus	surplus	NOUN
admet-394	209	37	.	.	PUNCT
admet-394	210	1	this	this	DET
admet-394	210	2	mode	mode	NOUN
admet-394	210	3	of	of	ADP
admet-394	210	4	regulation	regulation	NOUN
admet-394	210	5	has	have	AUX
admet-394	210	6	been	be	AUX
admet-394	210	7	characterized	characterize	VERB
admet-394	210	8	in	in	ADP
admet-394	210	9	s.	s.	PROPN
admet-394	210	10	cerevisiae	cerevisiae	PROPN
admet-394	210	11	,	,	PUNCT
admet-394	210	12	drosophila	drosophila	NOUN
admet-394	210	13	melanogaster	melanogaster	NOUN
admet-394	210	14	and	and	CCONJ
admet-394	210	15	homo	homo	NOUN
admet-394	210	16	sapiens	sapien	VERB
admet-394	210	17	[	[	X
admet-394	210	18	59	59	NUM
admet-394	210	19	-	-	SYM
admet-394	210	20	61	61	NUM
admet-394	210	21	]	]	PUNCT
admet-394	210	22	.	.	PUNCT
admet-394	211	1	thus	thus	ADV
admet-394	211	2	,	,	PUNCT
admet-394	211	3	in	in	ADP
admet-394	211	4	view	view	NOUN
admet-394	211	5	of	of	ADP
admet-394	211	6	the	the	DET
admet-394	211	7	increasing	increase	VERB
admet-394	211	8	number	number	NOUN
admet-394	211	9	of	of	ADP
admet-394	211	10	sensors	sensor	NOUN
admet-394	211	11	that	that	PRON
admet-394	211	12	are	be	AUX
admet-394	211	13	currently	currently	ADV
admet-394	211	14	being	be	AUX
admet-394	211	15	identified	identify	VERB
admet-394	211	16	in	in	ADP
admet-394	211	17	various	various	ADJ
admet-394	211	18	organisms	organism	NOUN
admet-394	211	19	,	,	PUNCT
admet-394	211	20	it	it	PRON
admet-394	211	21	is	be	AUX
admet-394	211	22	plausible	plausible	ADJ
admet-394	211	23	that	that	SCONJ
admet-394	211	24	c.	c.	PROPN
admet-394	211	25	elegans	elegan	NOUN
admet-394	211	26	oct-1	oct-1	ADV
admet-394	211	27	may	may	AUX
admet-394	211	28	indeed	indeed	ADV
admet-394	211	29	act	act	VERB
admet-394	211	30	either	either	CCONJ
admet-394	211	31	as	as	ADP
admet-394	211	32	a	a	DET
admet-394	211	33	non	non	ADJ
admet-394	211	34	-	-	ADJ
admet-394	211	35	transporting	transporting	ADJ
admet-394	211	36	or	or	CCONJ
admet-394	211	37	transporting	transport	VERB
admet-394	211	38	sensor	sensor	NOUN
admet-394	211	39	leading	lead	VERB
admet-394	211	40	to	to	ADP
admet-394	211	41	the	the	DET
admet-394	211	42	regulation	regulation	NOUN
admet-394	211	43	of	of	ADP
admet-394	211	44	oct-2	oct-2	NUM
admet-394	211	45	expression	expression	NOUN
admet-394	211	46	.	.	PUNCT
admet-394	212	1	if	if	SCONJ
admet-394	212	2	such	such	DET
admet-394	212	3	a	a	DET
admet-394	212	4	model	model	NOUN
admet-394	212	5	is	be	AUX
admet-394	212	6	possible	possible	ADJ
admet-394	212	7	,	,	PUNCT
admet-394	212	8	other	other	ADJ
admet-394	212	9	factors	factor	NOUN
admet-394	212	10	including	include	VERB
admet-394	212	11	kinases	kinase	NOUN
admet-394	212	12	and	and	CCONJ
admet-394	212	13	transcriptional	transcriptional	ADJ
admet-394	212	14	activators	activator	NOUN
admet-394	212	15	would	would	AUX
admet-394	212	16	be	be	AUX
admet-394	212	17	involved	involve	VERB
admet-394	212	18	in	in	ADP
admet-394	212	19	conveying	convey	VERB
admet-394	212	20	the	the	DET
admet-394	212	21	signal	signal	NOUN
admet-394	212	22	from	from	ADP
admet-394	212	23	oct-1	oct-1	ADV
admet-394	212	24	to	to	PART
admet-394	212	25	promote	promote	VERB
admet-394	212	26	oct-2	oct-2	NUM
admet-394	212	27	expression	expression	NOUN
admet-394	212	28	as	as	SCONJ
admet-394	212	29	shown	show	VERB
admet-394	212	30	for	for	ADP
admet-394	212	31	the	the	DET
admet-394	212	32	s.	s.	PROPN
admet-394	212	33	cerevisiae	cerevisiae	PROPN
admet-394	212	34	ssy1	ssy1	PROPN
admet-394	212	35	amino	amino	NOUN
admet-394	212	36	acid	acid	NOUN
admet-394	212	37	sensing	sense	VERB
admet-394	212	38	pathway	pathway	NOUN
admet-394	213	1	[	[	X
admet-394	213	2	62	62	NUM
admet-394	213	3	]	]	PUNCT
admet-394	213	4	.	.	PUNCT
admet-394	214	1	we	we	PRON
admet-394	214	2	propose	propose	VERB
admet-394	214	3	that	that	SCONJ
admet-394	214	4	exploiting	exploit	VERB
admet-394	214	5	oct-2	oct-2	VERB
admet-394	214	6	in	in	ADP
admet-394	214	7	c.	c.	NOUN
admet-394	214	8	elegans	elegan	NOUN
admet-394	214	9	could	could	AUX
admet-394	214	10	have	have	VERB
admet-394	214	11	far	far	ADV
admet-394	214	12	reaching	reach	VERB
admet-394	214	13	applications	application	NOUN
admet-394	214	14	that	that	PRON
admet-394	214	15	supersede	supersede	VERB
admet-394	214	16	admet	admet	PROPN
admet-394	214	17	&	&	CCONJ
admet-394	214	18	dmpk	dmpk	PROPN
admet-394	214	19	5(3	5(3	NUM
admet-394	214	20	)	)	PUNCT
admet-394	214	21	(	(	PUNCT
admet-394	214	22	2017	2017	NUM
admet-394	214	23	)	)	PUNCT
admet-394	214	24	146	146	NUM
admet-394	214	25	-	-	SYM
admet-394	214	26	158	158	NUM
admet-394	214	27	oct-1	oct-1	NUM
admet-394	214	28	and	and	CCONJ
admet-394	214	29	oct-2	oct-2	NUM
admet-394	214	30	in	in	ADP
admet-394	214	31	caenorhabditis	caenorhabditis	PROPN
admet-394	214	32	elegans	elegan	NOUN
admet-394	214	33	doi	doi	NOUN
admet-394	214	34	:	:	PUNCT
admet-394	214	35	10.5599	10.5599	NUM
admet-394	214	36	/	/	SYM
admet-394	214	37	admet.5.3.394	admet.5.3.394	X
admet-394	214	38	155	155	NUM
admet-394	214	39	other	other	ADJ
admet-394	214	40	whole	whole	ADJ
admet-394	214	41	model	model	NOUN
admet-394	214	42	systems	system	NOUN
admet-394	214	43	in	in	ADP
admet-394	214	44	drug	drug	NOUN
admet-394	214	45	discovery	discovery	NOUN
admet-394	214	46	programs	program	NOUN
admet-394	214	47	with	with	ADP
admet-394	214	48	respect	respect	NOUN
admet-394	214	49	to	to	ADP
admet-394	214	50	cost	cost	NOUN
admet-394	214	51	and	and	CCONJ
admet-394	214	52	time	time	NOUN
admet-394	214	53	.	.	PUNCT
admet-394	215	1	thus	thus	ADV
admet-394	215	2	,	,	PUNCT
admet-394	215	3	maintaining	maintain	VERB
admet-394	215	4	the	the	DET
admet-394	215	5	oct-2	oct-2	NOUN
admet-394	215	6	transporter	transporter	NOUN
admet-394	215	7	at	at	ADP
admet-394	215	8	optimal	optimal	ADJ
admet-394	215	9	levels	level	NOUN
admet-394	215	10	should	should	AUX
admet-394	215	11	be	be	AUX
admet-394	215	12	a	a	DET
admet-394	215	13	useful	useful	ADJ
admet-394	215	14	step	step	NOUN
admet-394	215	15	to	to	PART
admet-394	215	16	incorporate	incorporate	VERB
admet-394	215	17	into	into	ADP
admet-394	215	18	any	any	DET
admet-394	215	19	high	high	ADJ
admet-394	215	20	-	-	PUNCT
admet-394	215	21	throughput	throughput	NOUN
admet-394	215	22	screens	screen	NOUN
admet-394	215	23	to	to	PART
admet-394	215	24	improve	improve	VERB
admet-394	215	25	the	the	DET
admet-394	215	26	efficiency	efficiency	NOUN
admet-394	215	27	of	of	ADP
admet-394	215	28	identifying	identify	VERB
admet-394	215	29	cationic	cationic	ADJ
admet-394	215	30	bioactive	bioactive	ADJ
admet-394	215	31	molecules	molecule	NOUN
admet-394	215	32	from	from	ADP
admet-394	215	33	chemical	chemical	NOUN
admet-394	215	34	libraries	library	NOUN
admet-394	215	35	.	.	PUNCT
admet-394	216	1	the	the	DET
admet-394	216	2	overexpressed	overexpressed	ADJ
admet-394	216	3	oct-2	oct-2	VERB
admet-394	216	4	is	be	AUX
admet-394	216	5	expected	expect	VERB
admet-394	216	6	to	to	PART
admet-394	216	7	significantly	significantly	ADV
admet-394	216	8	alter	alter	VERB
admet-394	216	9	its	its	PRON
admet-394	216	10	kinetics	kinetic	NOUN
admet-394	216	11	such	such	ADJ
admet-394	216	12	that	that	SCONJ
admet-394	216	13	it	it	PRON
admet-394	216	14	can	can	AUX
admet-394	216	15	transport	transport	VERB
admet-394	216	16	chemicals	chemical	NOUN
admet-394	216	17	that	that	PRON
admet-394	216	18	are	be	AUX
admet-394	216	19	present	present	ADJ
admet-394	216	20	at	at	ADP
admet-394	216	21	lower	low	ADJ
admet-394	216	22	concentrations	concentration	NOUN
admet-394	216	23	in	in	ADP
admet-394	216	24	the	the	DET
admet-394	216	25	libraries	library	NOUN
admet-394	216	26	.	.	PUNCT
admet-394	217	1	we	we	PRON
admet-394	217	2	strongly	strongly	ADV
admet-394	217	3	suggest	suggest	VERB
admet-394	217	4	that	that	SCONJ
admet-394	217	5	the	the	DET
admet-394	217	6	previous	previous	ADJ
admet-394	217	7	barriers	barrier	NOUN
admet-394	217	8	posed	pose	VERB
admet-394	217	9	by	by	ADP
admet-394	217	10	c.	c.	PROPN
admet-394	217	11	elegans	elegan	NOUN
admet-394	217	12	to	to	PART
admet-394	217	13	find	find	VERB
admet-394	217	14	bioactive	bioactive	ADJ
admet-394	217	15	molecules	molecule	NOUN
admet-394	217	16	could	could	AUX
admet-394	217	17	be	be	AUX
admet-394	217	18	explained	explain	VERB
admet-394	217	19	by	by	ADP
admet-394	217	20	the	the	DET
admet-394	217	21	lack	lack	NOUN
admet-394	217	22	of	of	ADP
admet-394	217	23	an	an	DET
admet-394	217	24	activated	activate	VERB
admet-394	217	25	mechanism	mechanism	NOUN
admet-394	217	26	to	to	PART
admet-394	217	27	efficiently	efficiently	ADV
admet-394	217	28	take	take	VERB
admet-394	217	29	up	up	ADP
admet-394	217	30	compounds	compound	NOUN
admet-394	217	31	at	at	ADP
admet-394	217	32	lower	low	ADJ
admet-394	217	33	concentrations	concentration	NOUN
admet-394	217	34	.	.	PUNCT
admet-394	218	1	acknowledgments	acknowledgment	NOUN
admet-394	218	2	special	special	ADJ
admet-394	218	3	thanks	thank	NOUN
admet-394	218	4	to	to	ADP
admet-394	218	5	taramatti	taramatti	X
admet-394	218	6	harihar	harihar	PROPN
admet-394	218	7	for	for	ADP
admet-394	218	8	her	her	PRON
admet-394	218	9	editorial	editorial	ADJ
admet-394	218	10	comments	comment	NOUN
admet-394	218	11	.	.	PUNCT
admet-394	219	1	this	this	DET
admet-394	219	2	work	work	NOUN
admet-394	219	3	was	be	AUX
admet-394	219	4	funded	fund	VERB
admet-394	219	5	by	by	ADP
admet-394	219	6	the	the	DET
admet-394	219	7	research	research	NOUN
admet-394	219	8	project	project	NOUN
admet-394	219	9	grant	grant	NOUN
admet-394	219	10	201610pjt	201610pjt	NUM
admet-394	219	11	(	(	PUNCT
admet-394	219	12	377317	377317	NUM
admet-394	219	13	)	)	PUNCT
admet-394	219	14	to	to	PART
admet-394	219	15	d.r	d.r	PROPN
admet-394	219	16	.	.	PROPN
admet-394	219	17	from	from	ADP
admet-394	219	18	the	the	DET
admet-394	219	19	canadian	canadian	PROPN
admet-394	219	20	institute	institute	PROPN
admet-394	219	21	of	of	ADP
admet-394	219	22	health	health	PROPN
admet-394	219	23	research	research	NOUN
admet-394	219	24	.	.	PUNCT
admet-394	220	1	references	reference	NOUN
admet-394	220	2	[	[	X
admet-394	220	3	1	1	NUM
admet-394	220	4	]	]	X
admet-394	220	5	a.c	a.c	PROPN
admet-394	220	6	.	.	PROPN
admet-394	220	7	begg	begg	PROPN
admet-394	220	8	,	,	PUNCT
admet-394	220	9	f.a	f.a	PROPN
admet-394	220	10	.	.	PROPN
admet-394	220	11	stewart	stewart	PROPN
admet-394	220	12	,	,	PUNCT
admet-394	220	13	c.	c.	PROPN
admet-394	220	14	vens	vens	PROPN
admet-394	220	15	.	.	PUNCT
admet-394	220	16	strategies	strategy	NOUN
admet-394	220	17	to	to	PART
admet-394	220	18	improve	improve	VERB
admet-394	220	19	radiotherapy	radiotherapy	NOUN
admet-394	220	20	with	with	ADP
admet-394	220	21	targeted	target	VERB
admet-394	220	22	drugs	drug	NOUN
admet-394	220	23	,	,	PUNCT
admet-394	220	24	nat	nat	PROPN
admet-394	220	25	rev	rev	VERB
admet-394	220	26	cancer	cancer	NOUN
admet-394	220	27	11	11	NUM
admet-394	220	28	(	(	PUNCT
admet-394	220	29	2011	2011	NUM
admet-394	220	30	)	)	PUNCT
admet-394	220	31	239	239	NUM
admet-394	220	32	-	-	SYM
admet-394	220	33	253	253	NUM
admet-394	220	34	.	.	PUNCT
admet-394	221	1	[	[	X
admet-394	221	2	2	2	NUM
admet-394	221	3	]	]	X
admet-394	221	4	c.j	c.j	PROPN
admet-394	221	5	.	.	PROPN
admet-394	221	6	lord	lord	PROPN
admet-394	221	7	,	,	PUNCT
admet-394	221	8	a.	a.	PROPN
admet-394	221	9	ashworth	ashworth	PROPN
admet-394	221	10	.	.	PUNCT
admet-394	222	1	the	the	DET
admet-394	222	2	dna	dna	PROPN
admet-394	222	3	damage	damage	NOUN
admet-394	222	4	response	response	NOUN
admet-394	222	5	and	and	CCONJ
admet-394	222	6	cancer	cancer	NOUN
admet-394	222	7	therapy	therapy	NOUN
admet-394	222	8	,	,	PUNCT
admet-394	222	9	nature	nature	NOUN
admet-394	222	10	481	481	NUM
admet-394	222	11	(	(	PUNCT
admet-394	222	12	2012	2012	NUM
admet-394	222	13	)	)	PUNCT
admet-394	222	14	287	287	NUM
admet-394	222	15	-	-	SYM
admet-394	222	16	294	294	NUM
admet-394	222	17	.	.	PUNCT
admet-394	223	1	[	[	X
admet-394	223	2	3	3	X
admet-394	223	3	]	]	PUNCT
admet-394	223	4	k.	k.	PROPN
admet-394	223	5	cheung	cheung	PROPN
admet-394	223	6	-	-	PUNCT
admet-394	223	7	ong	ong	PROPN
admet-394	223	8	,	,	PUNCT
admet-394	223	9	g.	g.	PROPN
admet-394	223	10	giaever	giaever	PROPN
admet-394	223	11	,	,	PUNCT
admet-394	223	12	c.	c.	PROPN
admet-394	223	13	nislow	nislow	PROPN
admet-394	223	14	.	.	PUNCT
admet-394	224	1	dna	dna	NOUN
admet-394	224	2	-	-	PUNCT
admet-394	224	3	damaging	damaging	ADJ
admet-394	224	4	agents	agent	NOUN
admet-394	224	5	in	in	ADP
admet-394	224	6	cancer	cancer	NOUN
admet-394	224	7	chemotherapy	chemotherapy	NOUN
admet-394	224	8	:	:	PUNCT
admet-394	224	9	serendipity	serendipity	NOUN
admet-394	224	10	and	and	CCONJ
admet-394	224	11	chemical	chemical	NOUN
admet-394	224	12	biology	biology	NOUN
admet-394	224	13	,	,	PUNCT
admet-394	224	14	chem	chem	NOUN
admet-394	224	15	biol	biol	NOUN
admet-394	224	16	20	20	NUM
admet-394	224	17	(	(	PUNCT
admet-394	224	18	2013	2013	NUM
admet-394	224	19	)	)	PUNCT
admet-394	224	20	648	648	NUM
admet-394	224	21	-	-	SYM
admet-394	224	22	659	659	NUM
admet-394	224	23	.	.	PUNCT
admet-394	225	1	[	[	X
admet-394	225	2	4	4	NUM
admet-394	225	3	]	]	X
admet-394	225	4	m.r	m.r	PROPN
admet-394	225	5	.	.	PROPN
admet-394	225	6	kelley	kelley	PROPN
admet-394	225	7	,	,	PUNCT
admet-394	225	8	d.	d.	PROPN
admet-394	225	9	logsdon	logsdon	PROPN
admet-394	225	10	,	,	PUNCT
admet-394	225	11	m.l	m.l	PROPN
admet-394	225	12	.	.	PROPN
admet-394	225	13	fishel	fishel	PROPN
admet-394	225	14	.	.	PUNCT
admet-394	226	1	targeting	target	VERB
admet-394	226	2	dna	dna	PROPN
admet-394	226	3	repair	repair	NOUN
admet-394	226	4	pathways	pathway	NOUN
admet-394	226	5	for	for	ADP
admet-394	226	6	cancer	cancer	NOUN
admet-394	226	7	treatment	treatment	NOUN
admet-394	226	8	:	:	PUNCT
admet-394	226	9	what	what	PRON
admet-394	226	10	's	be	AUX
admet-394	226	11	new	new	ADJ
admet-394	226	12	?	?	PUNCT
admet-394	226	13	,	,	PUNCT
admet-394	226	14	future	future	ADJ
admet-394	226	15	oncol	oncol	ADJ
admet-394	226	16	10	10	NUM
admet-394	226	17	(	(	PUNCT
admet-394	226	18	2014	2014	NUM
admet-394	226	19	)	)	PUNCT
admet-394	226	20	1215	1215	NUM
admet-394	226	21	-	-	SYM
admet-394	226	22	1237	1237	NUM
admet-394	226	23	.	.	PUNCT
admet-394	227	1	[	[	X
admet-394	227	2	5	5	NUM
admet-394	227	3	]	]	X
admet-394	227	4	w.g	w.g	PROPN
admet-394	227	5	.	.	PROPN
admet-394	227	6	kaelin	kaelin	PROPN
admet-394	227	7	,	,	PUNCT
admet-394	227	8	jr	jr	PROPN
admet-394	227	9	.	.	PUNCT
admet-394	227	10	synthetic	synthetic	ADJ
admet-394	227	11	lethality	lethality	NOUN
admet-394	227	12	:	:	PUNCT
admet-394	227	13	a	a	DET
admet-394	227	14	framework	framework	NOUN
admet-394	227	15	for	for	ADP
admet-394	227	16	the	the	DET
admet-394	227	17	development	development	NOUN
admet-394	227	18	of	of	ADP
admet-394	227	19	wiser	wise	ADJ
admet-394	227	20	cancer	cancer	NOUN
admet-394	227	21	therapeutics	therapeutic	NOUN
admet-394	227	22	,	,	PUNCT
admet-394	227	23	genome	genome	NOUN
admet-394	227	24	med	me	VERB
admet-394	227	25	1	1	NUM
admet-394	227	26	(	(	PUNCT
admet-394	227	27	2009	2009	NUM
admet-394	227	28	)	)	PUNCT
admet-394	227	29	99	99	NUM
admet-394	227	30	.	.	PUNCT
admet-394	228	1	[	[	X
admet-394	228	2	6	6	NUM
admet-394	228	3	]	]	PUNCT
admet-394	228	4	a.	a.	NOUN
admet-394	228	5	bapat	bapat	PROPN
admet-394	228	6	,	,	PUNCT
admet-394	228	7	m.l	m.l	PROPN
admet-394	228	8	.	.	PROPN
admet-394	228	9	fishel	fishel	PROPN
admet-394	228	10	,	,	PUNCT
admet-394	228	11	m.r	m.r	PROPN
admet-394	228	12	.	.	PROPN
admet-394	228	13	kelley	kelley	PROPN
admet-394	228	14	.	.	PUNCT
admet-394	229	1	going	go	VERB
admet-394	229	2	ape	ape	NOUN
admet-394	229	3	as	as	ADP
admet-394	229	4	an	an	DET
admet-394	229	5	approach	approach	NOUN
admet-394	229	6	to	to	ADP
admet-394	229	7	cancer	cancer	NOUN
admet-394	229	8	therapeutics	therapeutic	NOUN
admet-394	229	9	,	,	PUNCT
admet-394	229	10	antioxid	antioxid	VERB
admet-394	229	11	redox	redox	NOUN
admet-394	229	12	signal	signal	NOUN
admet-394	229	13	11	11	NUM
admet-394	229	14	(	(	PUNCT
admet-394	229	15	2009	2009	NUM
admet-394	229	16	)	)	PUNCT
admet-394	229	17	651	651	NUM
admet-394	229	18	-	-	SYM
admet-394	229	19	668	668	NUM
admet-394	229	20	.	.	PUNCT
admet-394	230	1	[	[	X
admet-394	230	2	7	7	NUM
admet-394	230	3	]	]	X
admet-394	230	4	s.p	s.p	PROPN
admet-394	230	5	.	.	PROPN
admet-394	230	6	jackson	jackson	PROPN
admet-394	230	7	,	,	PUNCT
admet-394	230	8	j.	j.	PROPN
admet-394	230	9	bartek	bartek	PROPN
admet-394	230	10	.	.	PUNCT
admet-394	231	1	the	the	DET
admet-394	231	2	dna	dna	NOUN
admet-394	231	3	-	-	PUNCT
admet-394	231	4	damage	damage	NOUN
admet-394	231	5	response	response	NOUN
admet-394	231	6	in	in	ADP
admet-394	231	7	human	human	ADJ
admet-394	231	8	biology	biology	NOUN
admet-394	231	9	and	and	CCONJ
admet-394	231	10	disease	disease	NOUN
admet-394	231	11	,	,	PUNCT
admet-394	231	12	nature	nature	NOUN
admet-394	231	13	461	461	NUM
admet-394	231	14	(	(	PUNCT
admet-394	231	15	2009	2009	NUM
admet-394	231	16	)	)	PUNCT
admet-394	231	17	1071	1071	NUM
admet-394	231	18	-	-	SYM
admet-394	231	19	1078	1078	NUM
admet-394	231	20	.	.	PUNCT
admet-394	232	1	[	[	X
admet-394	232	2	8	8	NUM
admet-394	232	3	]	]	PUNCT
admet-394	232	4	a.	a.	NOUN
admet-394	232	5	ciccia	ciccia	PROPN
admet-394	232	6	,	,	PUNCT
admet-394	232	7	s.j	s.j	PROPN
admet-394	232	8	.	.	PROPN
admet-394	232	9	elledge	elledge	PROPN
admet-394	232	10	.	.	PUNCT
admet-394	233	1	the	the	DET
admet-394	233	2	dna	dna	PROPN
admet-394	233	3	damage	damage	NOUN
admet-394	233	4	response	response	NOUN
admet-394	233	5	:	:	PUNCT
admet-394	233	6	making	make	VERB
admet-394	233	7	it	it	PRON
admet-394	233	8	safe	safe	ADJ
admet-394	233	9	to	to	PART
admet-394	233	10	play	play	VERB
admet-394	233	11	with	with	ADP
admet-394	233	12	knives	knife	NOUN
admet-394	233	13	,	,	PUNCT
admet-394	233	14	mol	mol	ADP
admet-394	233	15	cell	cell	NOUN
admet-394	233	16	40	40	NUM
admet-394	233	17	(	(	PUNCT
admet-394	233	18	2010	2010	NUM
admet-394	233	19	)	)	PUNCT
admet-394	233	20	179	179	NUM
admet-394	233	21	-	-	SYM
admet-394	233	22	204	204	NUM
admet-394	233	23	.	.	PUNCT
admet-394	234	1	[	[	X
admet-394	234	2	9	9	NUM
admet-394	234	3	]	]	X
admet-394	234	4	v.d	v.d	PROPN
admet-394	234	5	.	.	PROPN
admet-394	234	6	peltekova	peltekova	PROPN
admet-394	234	7	,	,	PUNCT
admet-394	234	8	r.f	r.f	PROPN
admet-394	234	9	.	.	PROPN
admet-394	234	10	wintle	wintle	PROPN
admet-394	234	11	,	,	PUNCT
admet-394	234	12	l.a	l.a	PROPN
admet-394	234	13	.	.	PROPN
admet-394	234	14	rubin	rubin	PROPN
admet-394	234	15	,	,	PUNCT
admet-394	234	16	c.i	c.i	PROPN
admet-394	234	17	.	.	PROPN
admet-394	234	18	amos	amos	PROPN
admet-394	234	19	,	,	PUNCT
admet-394	234	20	q.	q.	PROPN
admet-394	234	21	huang	huang	PROPN
admet-394	234	22	,	,	PUNCT
admet-394	234	23	x.	x.	PROPN
admet-394	234	24	gu	gu	PROPN
admet-394	234	25	,	,	PUNCT
admet-394	234	26	b.	b.	PROPN
admet-394	234	27	newman	newman	PROPN
admet-394	234	28	,	,	PUNCT
admet-394	234	29	m.	m.	NOUN
admet-394	234	30	van	van	PROPN
admet-394	234	31	oene	oene	NOUN
admet-394	234	32	,	,	PUNCT
admet-394	234	33	d.	d.	PROPN
admet-394	234	34	cescon	cescon	PROPN
admet-394	234	35	,	,	PUNCT
admet-394	234	36	g.	g.	PROPN
admet-394	234	37	greenberg	greenberg	PROPN
admet-394	234	38	,	,	PUNCT
admet-394	234	39	a.m.	a.m.	PROPN
admet-394	234	40	griffiths	griffiths	PROPN
admet-394	234	41	,	,	PUNCT
admet-394	234	42	p.h	p.h	PROPN
admet-394	234	43	.	.	PROPN
admet-394	234	44	st	st	PROPN
admet-394	234	45	george	george	PROPN
admet-394	234	46	-	-	PUNCT
admet-394	234	47	hyslop	hyslop	PROPN
admet-394	234	48	,	,	PUNCT
admet-394	234	49	k.a	k.a	PROPN
admet-394	234	50	.	.	PROPN
admet-394	234	51	siminovitch	siminovitch	PROPN
admet-394	234	52	.	.	PUNCT
admet-394	235	1	functional	functional	ADJ
admet-394	235	2	variants	variant	NOUN
admet-394	235	3	of	of	ADP
admet-394	235	4	octn	octn	ADJ
admet-394	235	5	cation	cation	NOUN
admet-394	235	6	transporter	transporter	NOUN
admet-394	235	7	genes	gene	NOUN
admet-394	235	8	are	be	AUX
admet-394	235	9	associated	associate	VERB
admet-394	235	10	with	with	ADP
admet-394	235	11	crohn	crohn	PROPN
admet-394	235	12	disease	disease	PROPN
admet-394	235	13	,	,	PUNCT
admet-394	235	14	nat	nat	PROPN
admet-394	235	15	genet	genet	NOUN
admet-394	235	16	36	36	NUM
admet-394	235	17	(	(	PUNCT
admet-394	235	18	2004	2004	NUM
admet-394	235	19	)	)	PUNCT
admet-394	235	20	471	471	NUM
admet-394	235	21	-	-	SYM
admet-394	235	22	475	475	NUM
admet-394	235	23	.	.	PUNCT
admet-394	236	1	[	[	X
admet-394	236	2	10	10	NUM
admet-394	236	3	]	]	X
admet-394	236	4	s.t.d	s.t.d	PROPN
admet-394	236	5	.	.	PROPN
admet-394	236	6	consortium	consortium	PROPN
admet-394	236	7	,	,	PUNCT
admet-394	236	8	a.l	a.l	PROPN
admet-394	236	9	.	.	PROPN
admet-394	236	10	williams	williams	PROPN
admet-394	236	11	,	,	PUNCT
admet-394	236	12	s.b	s.b	PROPN
admet-394	236	13	.	.	PROPN
admet-394	236	14	jacobs	jacobs	PROPN
admet-394	236	15	,	,	PUNCT
admet-394	236	16	h.	h.	PROPN
admet-394	236	17	moreno	moreno	PROPN
admet-394	236	18	-	-	PUNCT
admet-394	236	19	macias	macias	PROPN
admet-394	236	20	,	,	PUNCT
admet-394	236	21	a.	a.	PROPN
admet-394	236	22	huerta	huerta	PROPN
admet-394	236	23	-	-	PUNCT
admet-394	236	24	chagoya	chagoya	PROPN
admet-394	236	25	,	,	PUNCT
admet-394	236	26	c.	c.	PROPN
admet-394	236	27	churchhouse	churchhouse	PROPN
admet-394	236	28	,	,	PUNCT
admet-394	236	29	c.	c.	PROPN
admet-394	236	30	marquez	marquez	PROPN
admet-394	236	31	-	-	PUNCT
admet-394	236	32	luna	luna	PROPN
admet-394	236	33	,	,	PUNCT
admet-394	236	34	h.	h.	PROPN
admet-394	236	35	garcia	garcia	PROPN
admet-394	236	36	-	-	PUNCT
admet-394	236	37	ortiz	ortiz	PROPN
admet-394	236	38	,	,	PUNCT
admet-394	236	39	m.j	m.j	PROPN
admet-394	236	40	.	.	PROPN
admet-394	236	41	gomez	gomez	PROPN
admet-394	236	42	-	-	PUNCT
admet-394	236	43	vazquez	vazquez	PROPN
admet-394	236	44	,	,	PUNCT
admet-394	236	45	n.p	n.p	PROPN
admet-394	236	46	.	.	PROPN
admet-394	236	47	burtt	burtt	PROPN
admet-394	236	48	,	,	PUNCT
admet-394	236	49	c.a	c.a	PROPN
admet-394	236	50	.	.	PROPN
admet-394	236	51	aguilarsalinas	aguilarsalinas	PROPN
admet-394	236	52	,	,	PUNCT
admet-394	236	53	c.	c.	PROPN
admet-394	236	54	gonzalez	gonzalez	PROPN
admet-394	236	55	-	-	PUNCT
admet-394	236	56	villalpando	villalpando	PROPN
admet-394	236	57	,	,	PUNCT
admet-394	236	58	j.c	j.c	PROPN
admet-394	236	59	.	.	PROPN
admet-394	236	60	florez	florez	PROPN
admet-394	236	61	,	,	PUNCT
admet-394	236	62	l.	l.	PROPN
admet-394	236	63	orozco	orozco	PROPN
admet-394	236	64	,	,	PUNCT
admet-394	236	65	c.a	c.a	PROPN
admet-394	236	66	.	.	PROPN
admet-394	236	67	haiman	haiman	PROPN
admet-394	236	68	,	,	PUNCT
admet-394	236	69	t.	t.	PROPN
admet-394	236	70	tusie	tusie	PROPN
admet-394	236	71	-	-	PUNCT
admet-394	236	72	luna	luna	PROPN
admet-394	236	73	,	,	PUNCT
admet-394	236	74	d.	d.	PROPN
admet-394	236	75	altshuler	altshuler	PROPN
admet-394	236	76	.	.	PUNCT
admet-394	237	1	sequence	sequence	NOUN
admet-394	237	2	variants	variant	NOUN
admet-394	237	3	in	in	ADP
admet-394	237	4	slc16a11	slc16a11	PROPN
admet-394	237	5	are	be	AUX
admet-394	237	6	a	a	DET
admet-394	237	7	common	common	ADJ
admet-394	237	8	risk	risk	NOUN
admet-394	237	9	factor	factor	NOUN
admet-394	237	10	for	for	ADP
admet-394	237	11	type	type	NOUN
admet-394	237	12	2	2	NUM
admet-394	237	13	diabetes	diabetes	NOUN
admet-394	237	14	in	in	ADP
admet-394	237	15	mexico	mexico	PROPN
admet-394	237	16	,	,	PUNCT
admet-394	237	17	nature	nature	NOUN
admet-394	237	18	506	506	NUM
admet-394	237	19	(	(	PUNCT
admet-394	237	20	2014	2014	NUM
admet-394	237	21	)	)	PUNCT
admet-394	237	22	97	97	NUM
admet-394	237	23	-	-	SYM
admet-394	237	24	101	101	NUM
admet-394	237	25	.	.	PUNCT
admet-394	238	1	[	[	X
admet-394	238	2	11	11	NUM
admet-394	238	3	]	]	PUNCT
admet-394	238	4	a.	a.	NOUN
admet-394	238	5	cesar	cesar	PROPN
admet-394	238	6	-	-	PUNCT
admet-394	238	7	razquin	razquin	PROPN
admet-394	238	8	,	,	PUNCT
admet-394	238	9	b.	b.	PROPN
admet-394	238	10	snijder	snijder	PROPN
admet-394	238	11	,	,	PUNCT
admet-394	238	12	t.	t.	PROPN
admet-394	238	13	frappier	frappier	PROPN
admet-394	238	14	-	-	PUNCT
admet-394	238	15	brinton	brinton	PROPN
admet-394	238	16	,	,	PUNCT
admet-394	238	17	r.	r.	PROPN
admet-394	238	18	isserlin	isserlin	PROPN
admet-394	238	19	,	,	PUNCT
admet-394	238	20	g.	g.	PROPN
admet-394	238	21	gyimesi	gyimesi	PROPN
admet-394	238	22	,	,	PUNCT
admet-394	238	23	x.	x.	PROPN
admet-394	238	24	bai	bai	PROPN
admet-394	238	25	,	,	PUNCT
admet-394	238	26	r.a	r.a	PROPN
admet-394	238	27	.	.	PROPN
admet-394	238	28	reithmeier	reithmeier	PROPN
admet-394	238	29	,	,	PUNCT
admet-394	238	30	d.	d.	PROPN
admet-394	238	31	hepworth	hepworth	PROPN
admet-394	238	32	,	,	PUNCT
admet-394	238	33	m.a	m.a	PROPN
admet-394	238	34	.	.	PROPN
admet-394	238	35	hediger	hediger	PROPN
admet-394	238	36	,	,	PUNCT
admet-394	238	37	a.m.	a.m.	PROPN
admet-394	238	38	edwards	edwards	PROPN
admet-394	238	39	,	,	PUNCT
admet-394	238	40	g.	g.	PROPN
admet-394	238	41	superti	superti	PROPN
admet-394	238	42	-	-	PUNCT
admet-394	238	43	furga	furga	NOUN
admet-394	238	44	.	.	PUNCT
admet-394	239	1	a	a	DET
admet-394	239	2	call	call	NOUN
admet-394	239	3	for	for	ADP
admet-394	239	4	systematic	systematic	ADJ
admet-394	239	5	research	research	NOUN
admet-394	239	6	on	on	ADP
admet-394	239	7	solute	solute	NOUN
admet-394	239	8	carriers	carrier	NOUN
admet-394	239	9	,	,	PUNCT
admet-394	239	10	cell	cell	NOUN
admet-394	239	11	162	162	NUM
admet-394	239	12	(	(	PUNCT
admet-394	239	13	2015	2015	NUM
admet-394	239	14	)	)	PUNCT
admet-394	239	15	478	478	NUM
admet-394	239	16	-	-	SYM
admet-394	239	17	487	487	NUM
admet-394	239	18	.	.	PUNCT
admet-394	240	1	[	[	X
admet-394	240	2	12	12	NUM
admet-394	240	3	]	]	X
admet-394	240	4	g.e	g.e	PROPN
admet-394	240	5	.	.	PROPN
admet-394	240	6	winter	winter	PROPN
admet-394	240	7	,	,	PUNCT
admet-394	240	8	b.	b.	PROPN
admet-394	240	9	radic	radic	PROPN
admet-394	240	10	,	,	PUNCT
admet-394	240	11	c.	c.	PROPN
admet-394	240	12	mayor	mayor	PROPN
admet-394	240	13	-	-	PUNCT
admet-394	240	14	ruiz	ruiz	NOUN
admet-394	240	15	,	,	PUNCT
admet-394	240	16	v.a	v.a	PROPN
admet-394	240	17	.	.	PROPN
admet-394	240	18	blomen	blomen	PROPN
admet-394	240	19	,	,	PUNCT
admet-394	240	20	c.	c.	PROPN
admet-394	240	21	trefzer	trefzer	NOUN
admet-394	240	22	,	,	PUNCT
admet-394	240	23	r.k	r.k	PROPN
admet-394	240	24	.	.	PROPN
admet-394	240	25	kandasamy	kandasamy	PROPN
admet-394	240	26	,	,	PUNCT
admet-394	240	27	k.v	k.v	PROPN
admet-394	240	28	.	.	PROPN
admet-394	240	29	huber	huber	PROPN
admet-394	240	30	,	,	PUNCT
admet-394	240	31	m.	m.	NOUN
admet-394	240	32	gridling	gridling	NOUN
admet-394	240	33	,	,	PUNCT
admet-394	240	34	d.	d.	PROPN
admet-394	240	35	chen	chen	PROPN
admet-394	240	36	,	,	PUNCT
admet-394	240	37	t.	t.	PROPN
admet-394	240	38	klampfl	klampfl	PROPN
admet-394	240	39	,	,	PUNCT
admet-394	240	40	r.	r.	PROPN
admet-394	240	41	kralovics	kralovics	PROPN
admet-394	240	42	,	,	PUNCT
admet-394	240	43	s.	s.	PROPN
admet-394	240	44	kubicek	kubicek	PROPN
admet-394	240	45	,	,	PUNCT
admet-394	240	46	o.	o.	PROPN
admet-394	240	47	fernandez	fernandez	PROPN
admet-394	240	48	-	-	PUNCT
admet-394	240	49	capetillo	capetillo	PROPN
admet-394	240	50	,	,	PUNCT
admet-394	240	51	t.r	t.r	PROPN
admet-394	240	52	.	.	PROPN
admet-394	240	53	brummelkamp	brummelkamp	PROPN
admet-394	240	54	,	,	PUNCT
admet-394	240	55	g.	g.	PROPN
admet-394	240	56	superti	superti	PROPN
admet-394	240	57	-	-	PUNCT
admet-394	240	58	furga	furga	NOUN
admet-394	240	59	.	.	PUNCT
admet-394	241	1	the	the	DET
admet-394	241	2	solute	solute	ADJ
admet-394	241	3	carrier	carrier	NOUN
admet-394	241	4	slc35f2	slc35f2	VERB
admet-394	241	5	enables	enable	VERB
admet-394	241	6	ym155	ym155	NOUN
admet-394	241	7	-	-	PUNCT
admet-394	241	8	mediated	mediate	VERB
admet-394	241	9	dna	dna	NOUN
admet-394	241	10	damage	damage	NOUN
admet-394	241	11	toxicity	toxicity	NOUN
admet-394	241	12	,	,	PUNCT
admet-394	241	13	nat	nat	PROPN
admet-394	241	14	chem	chem	NOUN
admet-394	241	15	biol	biol	NOUN
admet-394	241	16	10	10	NUM
admet-394	241	17	(	(	PUNCT
admet-394	241	18	2014	2014	NUM
admet-394	241	19	)	)	PUNCT
admet-394	241	20	768	768	NUM
admet-394	241	21	-	-	SYM
admet-394	241	22	773	773	NUM
admet-394	241	23	.	.	PUNCT
admet-394	242	1	[	[	X
admet-394	242	2	13	13	NUM
admet-394	242	3	]	]	X
admet-394	242	4	y.	y.	PROPN
admet-394	242	5	liu	liu	PROPN
admet-394	242	6	,	,	PUNCT
admet-394	242	7	x.	x.	PROPN
admet-394	242	8	zheng	zheng	PROPN
admet-394	242	9	,	,	PUNCT
admet-394	242	10	q.	q.	PROPN
admet-394	242	11	yu	yu	PROPN
admet-394	242	12	,	,	PUNCT
admet-394	242	13	h.	h.	PROPN
admet-394	242	14	wang	wang	PROPN
admet-394	242	15	,	,	PUNCT
admet-394	242	16	f.	f.	PROPN
admet-394	242	17	tan	tan	PROPN
admet-394	242	18	,	,	PUNCT
admet-394	242	19	q.	q.	PROPN
admet-394	242	20	zhu	zhu	PROPN
admet-394	242	21	,	,	PUNCT
admet-394	242	22	l.	l.	PROPN
admet-394	242	23	yuan	yuan	PROPN
admet-394	242	24	,	,	PUNCT
admet-394	242	25	h.	h.	PROPN
admet-394	242	26	jiang	jiang	PROPN
admet-394	242	27	,	,	PUNCT
admet-394	242	28	l.	l.	PROPN
admet-394	242	29	yu	yu	PROPN
admet-394	242	30	,	,	PUNCT
admet-394	242	31	s.	s.	PROPN
admet-394	242	32	zeng	zeng	PROPN
admet-394	242	33	.	.	PUNCT
admet-394	242	34	epigenetic	epigenetic	ADJ
admet-394	242	35	activation	activation	NOUN
admet-394	242	36	of	of	ADP
admet-394	242	37	the	the	DET
admet-394	242	38	drug	drug	NOUN
admet-394	242	39	transporter	transporter	NOUN
admet-394	242	40	oct2	oct2	NOUN
admet-394	242	41	sensitizes	sensitize	VERB
admet-394	242	42	renal	renal	ADJ
admet-394	242	43	cell	cell	NOUN
admet-394	242	44	carcinoma	carcinoma	NOUN
admet-394	242	45	to	to	ADP
admet-394	242	46	oxaliplatin	oxaliplatin	PROPN
admet-394	242	47	,	,	PUNCT
admet-394	242	48	sci	sci	PROPN
admet-394	242	49	transl	transl	PROPN
admet-394	242	50	med	me	VERB
admet-394	242	51	8	8	NUM
admet-394	242	52	(	(	PUNCT
admet-394	242	53	2016	2016	NUM
admet-394	242	54	)	)	PUNCT
admet-394	242	55	348ra397	348ra397	NUM
admet-394	242	56	.	.	PUNCT
admet-394	242	57	dindial	dindial	ADJ
admet-394	242	58	ramotar	ramotar	PROPN
admet-394	242	59	admet	admet	PROPN
admet-394	242	60	&	&	CCONJ
admet-394	242	61	dmpk	dmpk	PROPN
admet-394	242	62	5(3	5(3	NUM
admet-394	242	63	)	)	PUNCT
admet-394	242	64	(	(	PUNCT
admet-394	242	65	2017	2017	NUM
admet-394	242	66	)	)	PUNCT
admet-394	242	67	146	146	NUM
admet-394	242	68	-	-	SYM
admet-394	242	69	158	158	NUM
admet-394	242	70	156	156	NUM
admet-394	243	1	[	[	X
admet-394	243	2	14	14	NUM
admet-394	243	3	]	]	X
admet-394	243	4	d.l	d.l	PROPN
admet-394	243	5	.	.	PROPN
admet-394	243	6	white	white	PROPN
admet-394	243	7	,	,	PUNCT
admet-394	243	8	v.a	v.a	PROPN
admet-394	243	9	.	.	PROPN
admet-394	243	10	saunders	saunder	NOUN
admet-394	243	11	,	,	PUNCT
admet-394	243	12	p.	p.	PROPN
admet-394	243	13	dang	dang	PROPN
admet-394	243	14	,	,	PUNCT
admet-394	243	15	j.	j.	PROPN
admet-394	243	16	engler	engler	PROPN
admet-394	243	17	,	,	PUNCT
admet-394	243	18	t.p	t.p	PROPN
admet-394	243	19	.	.	PROPN
admet-394	243	20	hughes	hughes	PROPN
admet-394	243	21	.	.	PUNCT
admet-394	244	1	oct-1	oct-1	AUX
admet-394	244	2	activity	activity	NOUN
admet-394	244	3	measurement	measurement	NOUN
admet-394	244	4	provides	provide	VERB
admet-394	244	5	a	a	DET
admet-394	244	6	superior	superior	ADJ
admet-394	244	7	imatinib	imatinib	NOUN
admet-394	244	8	response	response	NOUN
admet-394	244	9	predictor	predictor	NOUN
admet-394	244	10	than	than	ADP
admet-394	244	11	screening	screen	VERB
admet-394	244	12	for	for	ADP
admet-394	244	13	single	single	ADJ
admet-394	244	14	-	-	PUNCT
admet-394	244	15	nucleotide	nucleotide	ADJ
admet-394	244	16	polymorphisms	polymorphism	NOUN
admet-394	244	17	of	of	ADP
admet-394	244	18	oct-1	oct-1	PRON
admet-394	244	19	,	,	PUNCT
admet-394	244	20	leukemia	leukemia	NOUN
admet-394	244	21	24	24	NUM
admet-394	244	22	(	(	PUNCT
admet-394	244	23	2010	2010	NUM
admet-394	244	24	)	)	PUNCT
admet-394	244	25	1962	1962	NUM
admet-394	244	26	-	-	SYM
admet-394	244	27	1965	1965	NUM
admet-394	244	28	.	.	PUNCT
admet-394	245	1	[	[	X
admet-394	245	2	15	15	NUM
admet-394	245	3	]	]	X
admet-394	245	4	m.l	m.l	PROPN
admet-394	245	5	.	.	PROPN
admet-394	245	6	becker	becker	PROPN
admet-394	245	7	,	,	PUNCT
admet-394	245	8	l.e	l.e	PROPN
admet-394	245	9	.	.	PROPN
admet-394	245	10	visser	visser	PROPN
admet-394	245	11	,	,	PUNCT
admet-394	245	12	r.h	r.h	PROPN
admet-394	245	13	.	.	PROPN
admet-394	245	14	van	van	PROPN
admet-394	245	15	schaik	schaik	NOUN
admet-394	245	16	,	,	PUNCT
admet-394	245	17	a.	a.	NOUN
admet-394	245	18	hofman	hofman	PROPN
admet-394	245	19	,	,	PUNCT
admet-394	245	20	a.g	a.g	PROPN
admet-394	245	21	.	.	PROPN
admet-394	245	22	uitterlinden	uitterlinden	PROPN
admet-394	245	23	,	,	PUNCT
admet-394	245	24	b.h	b.h	PROPN
admet-394	245	25	.	.	PROPN
admet-394	245	26	stricker	stricker	PROPN
admet-394	245	27	.	.	PUNCT
admet-394	246	1	genetic	genetic	ADJ
admet-394	246	2	variation	variation	NOUN
admet-394	246	3	in	in	ADP
admet-394	246	4	the	the	DET
admet-394	246	5	organic	organic	ADJ
admet-394	246	6	cation	cation	NOUN
admet-394	246	7	transporter	transporter	NOUN
admet-394	246	8	1	1	NUM
admet-394	246	9	is	be	AUX
admet-394	246	10	associated	associate	VERB
admet-394	246	11	with	with	ADP
admet-394	246	12	metformin	metformin	NOUN
admet-394	246	13	response	response	NOUN
admet-394	246	14	in	in	ADP
admet-394	246	15	patients	patient	NOUN
admet-394	246	16	with	with	ADP
admet-394	246	17	diabetes	diabetes	NOUN
admet-394	246	18	mellitus	mellitus	NOUN
admet-394	246	19	,	,	PUNCT
admet-394	246	20	pharmacogenomics	pharmacogenomics	PROPN
admet-394	246	21	j	j	PROPN
admet-394	246	22	9	9	NUM
admet-394	246	23	(	(	PUNCT
admet-394	246	24	2009	2009	NUM
admet-394	246	25	)	)	PUNCT
admet-394	246	26	242	242	NUM
admet-394	246	27	-	-	SYM
admet-394	246	28	247	247	NUM
admet-394	246	29	.	.	PUNCT
admet-394	247	1	[	[	X
admet-394	247	2	16	16	NUM
admet-394	247	3	]	]	X
admet-394	247	4	t.j	t.j	PROPN
admet-394	247	5	.	.	PROPN
admet-394	247	6	westmoreland	westmoreland	PROPN
admet-394	247	7	,	,	PUNCT
admet-394	247	8	s.m	s.m	PROPN
admet-394	247	9	.	.	PROPN
admet-394	247	10	wickramasekara	wickramasekara	PROPN
admet-394	247	11	,	,	PUNCT
admet-394	247	12	a.y	a.y	PROPN
admet-394	247	13	.	.	PROPN
admet-394	247	14	guo	guo	PROPN
admet-394	247	15	,	,	PUNCT
admet-394	247	16	a.l	a.l	PROPN
admet-394	247	17	.	.	PROPN
admet-394	247	18	selim	selim	PROPN
admet-394	247	19	,	,	PUNCT
admet-394	247	20	t.s	t.s	PROPN
admet-394	247	21	.	.	PROPN
admet-394	247	22	winsor	winsor	PROPN
admet-394	247	23	,	,	PUNCT
admet-394	247	24	a.l	a.l	PROPN
admet-394	247	25	.	.	PROPN
admet-394	247	26	greenleaf	greenleaf	PROPN
admet-394	247	27	,	,	PUNCT
admet-394	247	28	k.l	k.l	PROPN
admet-394	247	29	.	.	PROPN
admet-394	247	30	blackwell	blackwell	PROPN
admet-394	247	31	,	,	PUNCT
admet-394	247	32	j.a	j.a	PROPN
admet-394	247	33	.	.	PROPN
admet-394	247	34	olson	olson	PROPN
admet-394	247	35	,	,	PUNCT
admet-394	247	36	jr	jr	PROPN
admet-394	247	37	.	.	PROPN
admet-394	247	38	,	,	PUNCT
admet-394	247	39	j.r	j.r	PROPN
admet-394	247	40	.	.	PROPN
admet-394	247	41	marks	marks	PROPN
admet-394	247	42	,	,	PUNCT
admet-394	247	43	c.b	c.b	PROPN
admet-394	247	44	.	.	PROPN
admet-394	247	45	bennett	bennett	PROPN
admet-394	247	46	.	.	PUNCT
admet-394	248	1	comparative	comparative	ADJ
admet-394	248	2	genome	genome	NOUN
admet-394	248	3	-	-	PUNCT
admet-394	248	4	wide	wide	ADJ
admet-394	248	5	screening	screening	NOUN
admet-394	248	6	identifies	identify	VERB
admet-394	248	7	a	a	DET
admet-394	248	8	conserved	conserve	VERB
admet-394	248	9	doxorubicin	doxorubicin	PROPN
admet-394	248	10	repair	repair	NOUN
admet-394	248	11	network	network	NOUN
admet-394	248	12	that	that	PRON
admet-394	248	13	is	be	AUX
admet-394	248	14	diploid	diploid	ADJ
admet-394	248	15	specific	specific	ADJ
admet-394	248	16	in	in	ADP
admet-394	248	17	saccharomyces	saccharomyce	NOUN
admet-394	248	18	cerevisiae	cerevisiae	NOUN
admet-394	248	19	,	,	PUNCT
admet-394	248	20	plos	plos	PROPN
admet-394	248	21	one	one	NUM
admet-394	248	22	4	4	NUM
admet-394	248	23	(	(	PUNCT
admet-394	248	24	2009	2009	NUM
admet-394	248	25	)	)	PUNCT
admet-394	249	1	e5830	e5830	NOUN
admet-394	249	2	.	.	PUNCT
admet-394	250	1	[	[	X
admet-394	250	2	17	17	NUM
admet-394	250	3	]	]	X
admet-394	250	4	k.k	k.k	PROPN
admet-394	250	5	.	.	PROPN
admet-394	250	6	karukstis	karukstis	PROPN
admet-394	250	7	,	,	PUNCT
admet-394	250	8	e.h	e.h	PROPN
admet-394	250	9	.	.	PROPN
admet-394	250	10	thompson	thompson	PROPN
admet-394	250	11	,	,	PUNCT
admet-394	250	12	j.a	j.a	PROPN
admet-394	250	13	.	.	PROPN
admet-394	250	14	whiles	whiles	PROPN
admet-394	250	15	,	,	PUNCT
admet-394	250	16	r.j	r.j	PROPN
admet-394	250	17	.	.	PROPN
admet-394	250	18	rosenfeld	rosenfeld	PROPN
admet-394	250	19	.	.	PUNCT
admet-394	251	1	deciphering	decipher	VERB
admet-394	251	2	the	the	DET
admet-394	251	3	fluorescence	fluorescence	ADJ
admet-394	251	4	signature	signature	NOUN
admet-394	251	5	of	of	ADP
admet-394	251	6	daunomycin	daunomycin	PROPN
admet-394	251	7	and	and	CCONJ
admet-394	251	8	doxorubicin	doxorubicin	PROPN
admet-394	251	9	,	,	PUNCT
admet-394	251	10	biophys	biophy	NOUN
admet-394	251	11	chem	chem	NOUN
admet-394	251	12	73	73	NUM
admet-394	251	13	(	(	PUNCT
admet-394	251	14	1998	1998	NUM
admet-394	251	15	)	)	PUNCT
admet-394	251	16	249	249	NUM
admet-394	251	17	-	-	SYM
admet-394	251	18	263	263	NUM
admet-394	251	19	.	.	PUNCT
admet-394	252	1	[	[	X
admet-394	252	2	18	18	NUM
admet-394	252	3	]	]	X
admet-394	252	4	n.	n.	PROPN
admet-394	252	5	brosseau	brosseau	PROPN
admet-394	252	6	,	,	PUNCT
admet-394	252	7	e.	e.	PROPN
admet-394	252	8	andreev	andreev	PROPN
admet-394	252	9	,	,	PUNCT
admet-394	252	10	d.	d.	PROPN
admet-394	252	11	ramotar	ramotar	PROPN
admet-394	252	12	.	.	PUNCT
admet-394	253	1	complementation	complementation	NOUN
admet-394	253	2	of	of	ADP
admet-394	253	3	the	the	DET
admet-394	253	4	yeast	yeast	NOUN
admet-394	253	5	model	model	NOUN
admet-394	253	6	system	system	NOUN
admet-394	253	7	reveals	reveal	VERB
admet-394	253	8	that	that	SCONJ
admet-394	253	9	caenorhabditis	caenorhabditis	PROPN
admet-394	253	10	elegans	elegan	NOUN
admet-394	253	11	oct-1	oct-1	ADV
admet-394	253	12	is	be	AUX
admet-394	253	13	a	a	DET
admet-394	253	14	functional	functional	ADJ
admet-394	253	15	transporter	transporter	NOUN
admet-394	253	16	of	of	ADP
admet-394	253	17	anthracyclines	anthracycline	NOUN
admet-394	253	18	,	,	PUNCT
admet-394	253	19	plos	plos	PROPN
admet-394	253	20	one	one	NUM
admet-394	253	21	10	10	NUM
admet-394	253	22	(	(	PUNCT
admet-394	253	23	2015	2015	NUM
admet-394	253	24	)	)	PUNCT
admet-394	253	25	e0133182	e0133182	PROPN
admet-394	253	26	.	.	PUNCT
admet-394	254	1	[	[	X
admet-394	254	2	19	19	NUM
admet-394	254	3	]	]	X
admet-394	254	4	e.	e.	PROPN
admet-394	254	5	andreev	andreev	PROPN
admet-394	254	6	,	,	PUNCT
admet-394	254	7	n.	n.	PROPN
admet-394	254	8	brosseau	brosseau	PROPN
admet-394	254	9	,	,	PUNCT
admet-394	254	10	e.	e.	PROPN
admet-394	254	11	carmona	carmona	PROPN
admet-394	254	12	,	,	PUNCT
admet-394	254	13	a.m.	a.m.	PROPN
admet-394	254	14	mes	mes	PROPN
admet-394	254	15	-	-	PUNCT
admet-394	254	16	masson	masson	PROPN
admet-394	254	17	,	,	PUNCT
admet-394	254	18	d.	d.	PROPN
admet-394	254	19	ramotar	ramotar	PROPN
admet-394	254	20	.	.	PUNCT
admet-394	255	1	the	the	DET
admet-394	255	2	human	human	ADJ
admet-394	255	3	organic	organic	ADJ
admet-394	255	4	cation	cation	NOUN
admet-394	255	5	transporter	transporter	NOUN
admet-394	255	6	oct1	oct1	NOUN
admet-394	255	7	mediates	mediate	VERB
admet-394	255	8	high	high	ADJ
admet-394	255	9	affinity	affinity	NOUN
admet-394	255	10	uptake	uptake	NOUN
admet-394	255	11	of	of	ADP
admet-394	255	12	the	the	DET
admet-394	255	13	anticancer	anticancer	NOUN
admet-394	255	14	drug	drug	NOUN
admet-394	255	15	daunorubicin	daunorubicin	PROPN
admet-394	255	16	,	,	PUNCT
admet-394	255	17	sci	sci	PROPN
admet-394	255	18	rep	rep	PROPN
admet-394	255	19	6	6	NUM
admet-394	255	20	(	(	PUNCT
admet-394	255	21	2016	2016	NUM
admet-394	255	22	)	)	PUNCT
admet-394	255	23	20508	20508	NUM
admet-394	255	24	.	.	PUNCT
admet-394	256	1	[	[	X
admet-394	256	2	20	20	NUM
admet-394	256	3	]	]	PUNCT
admet-394	256	4	m.	m.	NOUN
admet-394	256	5	okabe	okabe	PROPN
admet-394	256	6	,	,	PUNCT
admet-394	256	7	m.	m.	NOUN
admet-394	256	8	unno	unno	NOUN
admet-394	256	9	,	,	PUNCT
admet-394	256	10	h.	h.	PROPN
admet-394	256	11	harigae	harigae	PROPN
admet-394	256	12	,	,	PUNCT
admet-394	256	13	m.	m.	NOUN
admet-394	256	14	kaku	kaku	PROPN
admet-394	256	15	,	,	PUNCT
admet-394	256	16	y.	y.	PROPN
admet-394	256	17	okitsu	okitsu	PROPN
admet-394	256	18	,	,	PUNCT
admet-394	256	19	t.	t.	PROPN
admet-394	256	20	sasaki	sasaki	PROPN
admet-394	256	21	,	,	PUNCT
admet-394	256	22	t.	t.	NOUN
admet-394	256	23	mizoi	mizoi	NOUN
admet-394	256	24	,	,	PUNCT
admet-394	256	25	k.	k.	PROPN
admet-394	256	26	shiiba	shiiba	PROPN
admet-394	256	27	,	,	PUNCT
admet-394	256	28	h.	h.	PROPN
admet-394	256	29	takanaga	takanaga	NOUN
admet-394	256	30	,	,	PUNCT
admet-394	256	31	t.	t.	PROPN
admet-394	256	32	terasaki	terasaki	PROPN
admet-394	256	33	,	,	PUNCT
admet-394	256	34	s.	s.	PROPN
admet-394	256	35	matsuno	matsuno	PROPN
admet-394	256	36	,	,	PUNCT
admet-394	256	37	i.	i.	PROPN
admet-394	256	38	sasaki	sasaki	PROPN
admet-394	256	39	,	,	PUNCT
admet-394	256	40	s.	s.	PROPN
admet-394	256	41	ito	ito	PROPN
admet-394	256	42	,	,	PUNCT
admet-394	256	43	t.	t.	PROPN
admet-394	256	44	abe	abe	PROPN
admet-394	256	45	.	.	PUNCT
admet-394	257	1	characterization	characterization	NOUN
admet-394	257	2	of	of	ADP
admet-394	257	3	the	the	DET
admet-394	257	4	organic	organic	ADJ
admet-394	257	5	cation	cation	NOUN
admet-394	257	6	transporter	transporter	NOUN
admet-394	257	7	slc22a16	slc22a16	NOUN
admet-394	257	8	:	:	PUNCT
admet-394	257	9	a	a	DET
admet-394	257	10	doxorubicin	doxorubicin	PROPN
admet-394	257	11	importer	importer	NOUN
admet-394	257	12	,	,	PUNCT
admet-394	257	13	biochem	biochem	PROPN
admet-394	257	14	biophys	biophy	NOUN
admet-394	257	15	res	re	NOUN
admet-394	257	16	commun	commun	PROPN
admet-394	257	17	333	333	NUM
admet-394	257	18	(	(	PUNCT
admet-394	257	19	2005	2005	NUM
admet-394	257	20	)	)	PUNCT
admet-394	257	21	754	754	NUM
admet-394	257	22	-	-	SYM
admet-394	257	23	762	762	NUM
admet-394	257	24	.	.	PUNCT
admet-394	258	1	[	[	X
admet-394	258	2	21	21	NUM
admet-394	258	3	]	]	X
admet-394	258	4	m.	m.	NOUN
admet-394	258	5	okabe	okabe	PROPN
admet-394	258	6	,	,	PUNCT
admet-394	258	7	g.	g.	PROPN
admet-394	258	8	szakacs	szakacs	PROPN
admet-394	258	9	,	,	PUNCT
admet-394	258	10	m.a	m.a	PROPN
admet-394	258	11	.	.	PROPN
admet-394	258	12	reimers	reimer	NOUN
admet-394	258	13	,	,	PUNCT
admet-394	258	14	t.	t.	PROPN
admet-394	258	15	suzuki	suzuki	PROPN
admet-394	258	16	,	,	PUNCT
admet-394	258	17	m.d	m.d	PROPN
admet-394	258	18	.	.	PROPN
admet-394	258	19	hall	hall	PROPN
admet-394	258	20	,	,	PUNCT
admet-394	258	21	t.	t.	PROPN
admet-394	258	22	abe	abe	PROPN
admet-394	258	23	,	,	PUNCT
admet-394	258	24	j.n	j.n	PROPN
admet-394	258	25	.	.	PROPN
admet-394	258	26	weinstein	weinstein	PROPN
admet-394	258	27	,	,	PUNCT
admet-394	258	28	m.m	m.m	PROPN
admet-394	258	29	.	.	PROPN
admet-394	258	30	gottesman	gottesman	NOUN
admet-394	258	31	.	.	PUNCT
admet-394	258	32	profiling	profile	VERB
admet-394	258	33	slco	slco	NOUN
admet-394	258	34	and	and	CCONJ
admet-394	258	35	slc22	slc22	NOUN
admet-394	258	36	genes	gene	NOUN
admet-394	258	37	in	in	ADP
admet-394	258	38	the	the	DET
admet-394	258	39	nci-60	nci-60	PROPN
admet-394	258	40	cancer	cancer	NOUN
admet-394	258	41	cell	cell	NOUN
admet-394	258	42	lines	line	NOUN
admet-394	258	43	to	to	PART
admet-394	258	44	identify	identify	VERB
admet-394	258	45	drug	drug	NOUN
admet-394	258	46	uptake	uptake	ADJ
admet-394	258	47	transporters	transporter	NOUN
admet-394	258	48	,	,	PUNCT
admet-394	258	49	mol	mol	ADP
admet-394	258	50	cancer	cancer	NOUN
admet-394	258	51	ther	ther	PROPN
admet-394	258	52	7	7	NUM
admet-394	258	53	(	(	PUNCT
admet-394	258	54	2008	2008	NUM
admet-394	258	55	)	)	PUNCT
admet-394	258	56	3081	3081	NUM
admet-394	258	57	-	-	SYM
admet-394	258	58	3091	3091	NUM
admet-394	258	59	.	.	PUNCT
admet-394	259	1	[	[	X
admet-394	259	2	22	22	NUM
admet-394	259	3	]	]	X
admet-394	259	4	j.w	j.w	PROPN
admet-394	259	5	.	.	PROPN
admet-394	259	6	lown	lown	PROPN
admet-394	259	7	.	.	PUNCT
admet-394	260	1	anthracycline	anthracycline	PROPN
admet-394	260	2	and	and	CCONJ
admet-394	260	3	anthraquinone	anthraquinone	NOUN
admet-394	260	4	anticancer	anticancer	NOUN
admet-394	260	5	agents	agent	NOUN
admet-394	260	6	:	:	PUNCT
admet-394	260	7	current	current	ADJ
admet-394	260	8	status	status	NOUN
admet-394	260	9	and	and	CCONJ
admet-394	260	10	recent	recent	ADJ
admet-394	260	11	developments	development	NOUN
admet-394	260	12	,	,	PUNCT
admet-394	260	13	pharmacol	pharmacol	VERB
admet-394	260	14	ther	ther	ADV
admet-394	260	15	60	60	NUM
admet-394	260	16	(	(	PUNCT
admet-394	260	17	1993	1993	NUM
admet-394	260	18	)	)	PUNCT
admet-394	260	19	185	185	NUM
admet-394	260	20	-	-	SYM
admet-394	260	21	214	214	NUM
admet-394	260	22	.	.	PUNCT
admet-394	261	1	[	[	X
admet-394	261	2	23	23	NUM
admet-394	261	3	]	]	X
admet-394	261	4	h.	h.	PROPN
admet-394	261	5	dohner	dohner	PROPN
admet-394	261	6	,	,	PUNCT
admet-394	261	7	e.h	e.h	PROPN
admet-394	261	8	.	.	PROPN
admet-394	261	9	estey	estey	PROPN
admet-394	261	10	,	,	PUNCT
admet-394	261	11	s.	s.	PROPN
admet-394	261	12	amadori	amadori	PROPN
admet-394	261	13	,	,	PUNCT
admet-394	261	14	f.r	f.r	PROPN
admet-394	261	15	.	.	PROPN
admet-394	261	16	appelbaum	appelbaum	PROPN
admet-394	261	17	,	,	PUNCT
admet-394	261	18	t.	t.	PROPN
admet-394	261	19	buchner	buchner	PROPN
admet-394	261	20	,	,	PUNCT
admet-394	261	21	a.k	a.k	PROPN
admet-394	261	22	.	.	PROPN
admet-394	261	23	burnett	burnett	PROPN
admet-394	261	24	,	,	PUNCT
admet-394	261	25	h.	h.	PROPN
admet-394	261	26	dombret	dombret	PROPN
admet-394	261	27	,	,	PUNCT
admet-394	261	28	p.	p.	PROPN
admet-394	261	29	fenaux	fenaux	PROPN
admet-394	261	30	,	,	PUNCT
admet-394	261	31	d.	d.	PROPN
admet-394	261	32	grimwade	grimwade	PROPN
admet-394	261	33	,	,	PUNCT
admet-394	261	34	r.a	r.a	PROPN
admet-394	261	35	.	.	PROPN
admet-394	261	36	larson	larson	PROPN
admet-394	261	37	,	,	PUNCT
admet-394	261	38	f.	f.	PROPN
admet-394	261	39	lo	lo	PROPN
admet-394	261	40	-	-	PUNCT
admet-394	261	41	coco	coco	PROPN
admet-394	261	42	,	,	PUNCT
admet-394	261	43	t.	t.	PROPN
admet-394	261	44	naoe	naoe	PROPN
admet-394	261	45	,	,	PUNCT
admet-394	261	46	d.	d.	PROPN
admet-394	261	47	niederwieser	niederwieser	PROPN
admet-394	261	48	,	,	PUNCT
admet-394	261	49	g.j	g.j	PROPN
admet-394	261	50	.	.	PROPN
admet-394	261	51	ossenkoppele	ossenkoppele	PROPN
admet-394	261	52	,	,	PUNCT
admet-394	261	53	m.a	m.a	PROPN
admet-394	261	54	.	.	PROPN
admet-394	261	55	sanz	sanz	PROPN
admet-394	261	56	,	,	PUNCT
admet-394	261	57	j.	j.	PROPN
admet-394	261	58	sierra	sierra	PROPN
admet-394	261	59	,	,	PUNCT
admet-394	261	60	m.s	m.s	PROPN
admet-394	261	61	.	.	PROPN
admet-394	261	62	tallman	tallman	PROPN
admet-394	261	63	,	,	PUNCT
admet-394	261	64	b.	b.	PROPN
admet-394	261	65	lowenberg	lowenberg	PROPN
admet-394	261	66	,	,	PUNCT
admet-394	261	67	c.d	c.d	PROPN
admet-394	261	68	.	.	PROPN
admet-394	261	69	bloomfield	bloomfield	PROPN
admet-394	261	70	.	.	PUNCT
admet-394	261	71	diagnosis	diagnosis	NOUN
admet-394	261	72	and	and	CCONJ
admet-394	261	73	management	management	NOUN
admet-394	261	74	of	of	ADP
admet-394	261	75	acute	acute	ADJ
admet-394	261	76	myeloid	myeloid	NOUN
admet-394	261	77	leukemia	leukemia	NOUN
admet-394	261	78	in	in	ADP
admet-394	261	79	adults	adult	NOUN
admet-394	261	80	:	:	PUNCT
admet-394	261	81	recommendations	recommendation	NOUN
admet-394	261	82	from	from	ADP
admet-394	261	83	an	an	DET
admet-394	261	84	international	international	ADJ
admet-394	261	85	expert	expert	NOUN
admet-394	261	86	panel	panel	NOUN
admet-394	261	87	,	,	PUNCT
admet-394	261	88	on	on	ADP
admet-394	261	89	behalf	behalf	NOUN
admet-394	261	90	of	of	ADP
admet-394	261	91	the	the	DET
admet-394	261	92	european	european	PROPN
admet-394	261	93	leukemianet	leukemianet	NOUN
admet-394	261	94	,	,	PUNCT
admet-394	261	95	blood	blood	NOUN
admet-394	261	96	115	115	NUM
admet-394	261	97	(	(	PUNCT
admet-394	261	98	2010	2010	NUM
admet-394	261	99	)	)	PUNCT
admet-394	261	100	453	453	NUM
admet-394	261	101	-	-	SYM
admet-394	261	102	474	474	NUM
admet-394	261	103	.	.	PUNCT
admet-394	262	1	[	[	X
admet-394	262	2	24	24	NUM
admet-394	262	3	]	]	SYM
admet-394	262	4	t.r	t.r	PROPN
admet-394	262	5	.	.	PROPN
admet-394	262	6	chauncey	chauncey	PROPN
admet-394	262	7	.	.	PUNCT
admet-394	262	8	drug	drug	NOUN
admet-394	262	9	resistance	resistance	NOUN
admet-394	262	10	mechanisms	mechanism	NOUN
admet-394	262	11	in	in	ADP
admet-394	262	12	acute	acute	ADJ
admet-394	262	13	leukemia	leukemia	NOUN
admet-394	262	14	,	,	PUNCT
admet-394	262	15	curr	curr	PROPN
admet-394	262	16	opin	opin	NOUN
admet-394	262	17	oncol	oncol	ADJ
admet-394	262	18	13	13	NUM
admet-394	262	19	(	(	PUNCT
admet-394	262	20	2001	2001	NUM
admet-394	262	21	)	)	PUNCT
admet-394	262	22	21	21	NUM
admet-394	262	23	-	-	SYM
admet-394	262	24	26	26	NUM
admet-394	262	25	.	.	PUNCT
admet-394	263	1	[	[	X
admet-394	263	2	25	25	NUM
admet-394	263	3	]	]	X
admet-394	263	4	j.p	j.p	PROPN
admet-394	263	5	.	.	PROPN
admet-394	263	6	marie	marie	PROPN
admet-394	263	7	.	.	PUNCT
admet-394	263	8	drug	drug	NOUN
admet-394	263	9	resistance	resistance	NOUN
admet-394	263	10	in	in	ADP
admet-394	263	11	hematologic	hematologic	NOUN
admet-394	263	12	malignancies	malignancy	NOUN
admet-394	263	13	,	,	PUNCT
admet-394	263	14	curr	curr	PROPN
admet-394	263	15	opin	opin	PROPN
admet-394	263	16	oncol	oncol	ADJ
admet-394	263	17	13	13	NUM
admet-394	263	18	(	(	PUNCT
admet-394	263	19	2001	2001	NUM
admet-394	263	20	)	)	PUNCT
admet-394	263	21	463	463	NUM
admet-394	263	22	-	-	SYM
admet-394	263	23	469	469	NUM
admet-394	263	24	.	.	PUNCT
admet-394	264	1	[	[	X
admet-394	264	2	26	26	NUM
admet-394	264	3	]	]	X
admet-394	264	4	j.c	j.c	PROPN
admet-394	264	5	.	.	PROPN
admet-394	264	6	byrd	byrd	PROPN
admet-394	264	7	,	,	PUNCT
admet-394	264	8	k.	k.	PROPN
admet-394	264	9	mrozek	mrozek	PROPN
admet-394	264	10	,	,	PUNCT
admet-394	264	11	r.k	r.k	PROPN
admet-394	264	12	.	.	PROPN
admet-394	264	13	dodge	dodge	PROPN
admet-394	264	14	,	,	PUNCT
admet-394	264	15	a.j	a.j	PROPN
admet-394	264	16	.	.	PROPN
admet-394	264	17	carroll	carroll	PROPN
admet-394	264	18	,	,	PUNCT
admet-394	264	19	c.g	c.g	PROPN
admet-394	264	20	.	.	PROPN
admet-394	264	21	edwards	edwards	PROPN
admet-394	264	22	,	,	PUNCT
admet-394	264	23	d.c	d.c	PROPN
admet-394	264	24	.	.	PROPN
admet-394	264	25	arthur	arthur	PROPN
admet-394	264	26	,	,	PUNCT
admet-394	264	27	m.j	m.j	PROPN
admet-394	264	28	.	.	PROPN
admet-394	264	29	pettenati	pettenati	PROPN
admet-394	264	30	,	,	PUNCT
admet-394	264	31	s.r	s.r	PROPN
admet-394	264	32	.	.	PROPN
admet-394	264	33	patil	patil	PROPN
admet-394	264	34	,	,	PUNCT
admet-394	264	35	k.w	k.w	PROPN
admet-394	264	36	.	.	PROPN
admet-394	264	37	rao	rao	PROPN
admet-394	264	38	,	,	PUNCT
admet-394	264	39	m.s	m.s	PROPN
admet-394	264	40	.	.	PROPN
admet-394	264	41	watson	watson	PROPN
admet-394	264	42	,	,	PUNCT
admet-394	264	43	p.r	p.r	PROPN
admet-394	264	44	.	.	PROPN
admet-394	264	45	koduru	koduru	PROPN
admet-394	264	46	,	,	PUNCT
admet-394	264	47	j.o	j.o	PROPN
admet-394	264	48	.	.	PROPN
admet-394	264	49	moore	moore	PROPN
admet-394	264	50	,	,	PUNCT
admet-394	264	51	r.m	r.m	PROPN
admet-394	264	52	.	.	PROPN
admet-394	264	53	stone	stone	PROPN
admet-394	264	54	,	,	PUNCT
admet-394	264	55	r.j	r.j	PROPN
admet-394	264	56	.	.	PROPN
admet-394	264	57	mayer	mayer	PROPN
admet-394	264	58	,	,	PUNCT
admet-394	264	59	e.j	e.j	PROPN
admet-394	264	60	.	.	PROPN
admet-394	264	61	feldman	feldman	PROPN
admet-394	264	62	,	,	PUNCT
admet-394	264	63	f.r	f.r	PROPN
admet-394	264	64	.	.	NOUN
admet-394	264	65	davey	davey	PROPN
admet-394	264	66	,	,	PUNCT
admet-394	264	67	c.a	c.a	PROPN
admet-394	264	68	.	.	PROPN
admet-394	264	69	schiffer	schiffer	PROPN
admet-394	264	70	,	,	PUNCT
admet-394	264	71	r.a	r.a	PROPN
admet-394	264	72	.	.	PROPN
admet-394	264	73	larson	larson	PROPN
admet-394	264	74	,	,	PUNCT
admet-394	264	75	c.d	c.d	PROPN
admet-394	264	76	.	.	PROPN
admet-394	264	77	bloomfield	bloomfield	PROPN
admet-394	264	78	.	.	PUNCT
admet-394	265	1	pretreatment	pretreatment	NOUN
admet-394	265	2	cytogenetic	cytogenetic	ADJ
admet-394	265	3	abnormalities	abnormality	NOUN
admet-394	265	4	are	be	AUX
admet-394	265	5	predictive	predictive	ADJ
admet-394	265	6	of	of	ADP
admet-394	265	7	induction	induction	NOUN
admet-394	265	8	success	success	NOUN
admet-394	265	9	,	,	PUNCT
admet-394	265	10	cumulative	cumulative	ADJ
admet-394	265	11	incidence	incidence	NOUN
admet-394	265	12	of	of	ADP
admet-394	265	13	relapse	relapse	NOUN
admet-394	265	14	,	,	PUNCT
admet-394	265	15	and	and	CCONJ
admet-394	265	16	overall	overall	ADJ
admet-394	265	17	survival	survival	NOUN
admet-394	265	18	in	in	ADP
admet-394	265	19	adult	adult	NOUN
admet-394	265	20	patients	patient	NOUN
admet-394	265	21	with	with	ADP
admet-394	265	22	de	de	X
admet-394	265	23	novo	novo	PROPN
admet-394	265	24	acute	acute	PROPN
admet-394	265	25	myeloid	myeloid	PROPN
admet-394	265	26	leukemia	leukemia	NOUN
admet-394	265	27	:	:	PUNCT
admet-394	265	28	results	result	NOUN
admet-394	265	29	from	from	ADP
admet-394	265	30	cancer	cancer	NOUN
admet-394	265	31	and	and	CCONJ
admet-394	265	32	leukemia	leukemia	NOUN
admet-394	265	33	group	group	NOUN
admet-394	265	34	b	b	PROPN
admet-394	265	35	(	(	PUNCT
admet-394	265	36	calgb	calgb	PROPN
admet-394	265	37	8461	8461	NUM
admet-394	265	38	)	)	PUNCT
admet-394	265	39	,	,	PUNCT
admet-394	265	40	blood	blood	NOUN
admet-394	265	41	100	100	NUM
admet-394	265	42	(	(	PUNCT
admet-394	265	43	2002	2002	NUM
admet-394	265	44	)	)	PUNCT
admet-394	265	45	4325	4325	NUM
admet-394	265	46	-	-	SYM
admet-394	265	47	4336	4336	NUM
admet-394	265	48	.	.	PUNCT
admet-394	266	1	[	[	X
admet-394	266	2	27	27	NUM
admet-394	266	3	]	]	X
admet-394	266	4	l.p	l.p	PROPN
admet-394	266	5	.	.	PROPN
admet-394	266	6	o'reilly	o'reilly	PROPN
admet-394	266	7	,	,	PUNCT
admet-394	266	8	c.j	c.j	PROPN
admet-394	266	9	.	.	PROPN
admet-394	266	10	luke	luke	PROPN
admet-394	266	11	,	,	PUNCT
admet-394	266	12	d.h	d.h	PROPN
admet-394	266	13	.	.	PROPN
admet-394	266	14	perlmutter	perlmutter	PROPN
admet-394	266	15	,	,	PUNCT
admet-394	266	16	g.a	g.a	PROPN
admet-394	266	17	.	.	PROPN
admet-394	266	18	silverman	silverman	PROPN
admet-394	266	19	,	,	PUNCT
admet-394	266	20	s.c	s.c	PROPN
admet-394	266	21	.	.	PROPN
admet-394	266	22	pak	pak	PROPN
admet-394	266	23	.	.	PUNCT
admet-394	267	1	c.	c.	PROPN
admet-394	267	2	elegans	elegans	PROPN
admet-394	267	3	in	in	ADP
admet-394	267	4	high	high	ADJ
admet-394	267	5	-	-	PUNCT
admet-394	267	6	throughput	throughput	NOUN
admet-394	267	7	drug	drug	NOUN
admet-394	267	8	discovery	discovery	NOUN
admet-394	267	9	,	,	PUNCT
admet-394	267	10	adv	adv	PROPN
admet-394	267	11	drug	drug	NOUN
admet-394	267	12	deliv	deliv	NOUN
admet-394	267	13	rev	rev	VERB
admet-394	267	14	69	69	NUM
admet-394	267	15	-	-	SYM
admet-394	267	16	70	70	NUM
admet-394	267	17	(	(	PUNCT
admet-394	267	18	2014	2014	NUM
admet-394	267	19	)	)	PUNCT
admet-394	267	20	247	247	NUM
admet-394	267	21	-	-	SYM
admet-394	267	22	253	253	NUM
admet-394	267	23	.	.	PUNCT
admet-394	268	1	[	[	X
admet-394	268	2	28	28	NUM
admet-394	268	3	]	]	X
admet-394	268	4	t.	t.	PROPN
admet-394	268	5	kaletta	kaletta	PROPN
admet-394	268	6	,	,	PUNCT
admet-394	268	7	m.o	m.o	PROPN
admet-394	268	8	.	.	PROPN
admet-394	268	9	hengartner	hengartner	PROPN
admet-394	268	10	.	.	PUNCT
admet-394	269	1	finding	find	VERB
admet-394	269	2	function	function	NOUN
admet-394	269	3	in	in	ADP
admet-394	269	4	novel	novel	ADJ
admet-394	269	5	targets	target	NOUN
admet-394	269	6	:	:	PUNCT
admet-394	269	7	c.	c.	NOUN
admet-394	269	8	elegans	elegan	NOUN
admet-394	269	9	as	as	ADP
admet-394	269	10	a	a	DET
admet-394	269	11	model	model	NOUN
admet-394	269	12	organism	organism	NOUN
admet-394	269	13	,	,	PUNCT
admet-394	269	14	nat	nat	PROPN
admet-394	269	15	rev	rev	VERB
admet-394	269	16	drug	drug	PROPN
admet-394	269	17	discov	discov	PROPN
admet-394	269	18	5	5	NUM
admet-394	269	19	(	(	PUNCT
admet-394	269	20	2006	2006	NUM
admet-394	269	21	)	)	PUNCT
admet-394	269	22	387	387	NUM
admet-394	269	23	-	-	SYM
admet-394	269	24	398	398	NUM
admet-394	269	25	.	.	PUNCT
admet-394	270	1	[	[	X
admet-394	270	2	29	29	NUM
admet-394	270	3	]	]	X
admet-394	270	4	i.k	i.k	PROPN
admet-394	270	5	.	.	PROPN
admet-394	270	6	cheah	cheah	PROPN
admet-394	270	7	,	,	PUNCT
admet-394	270	8	r.l	r.l	PROPN
admet-394	270	9	.	.	PROPN
admet-394	270	10	ong	ong	PROPN
admet-394	270	11	,	,	PUNCT
admet-394	270	12	j.	j.	PROPN
admet-394	270	13	gruber	gruber	PROPN
admet-394	270	14	,	,	PUNCT
admet-394	270	15	t.s	t.s	PROPN
admet-394	270	16	.	.	PROPN
admet-394	270	17	yew	yew	PROPN
admet-394	270	18	,	,	PUNCT
admet-394	270	19	l.f	l.f	PROPN
admet-394	270	20	.	.	PROPN
admet-394	270	21	ng	ng	PROPN
admet-394	270	22	,	,	PUNCT
admet-394	270	23	c.b	c.b	PROPN
admet-394	270	24	.	.	PROPN
admet-394	270	25	chen	chen	PROPN
admet-394	270	26	,	,	PUNCT
admet-394	270	27	b.	b.	PROPN
admet-394	270	28	halliwell	halliwell	PROPN
admet-394	270	29	.	.	PUNCT
admet-394	271	1	knockout	knockout	NOUN
admet-394	271	2	of	of	ADP
admet-394	271	3	a	a	DET
admet-394	271	4	putative	putative	ADJ
admet-394	271	5	ergothioneine	ergothioneine	NOUN
admet-394	271	6	transporter	transporter	NOUN
admet-394	271	7	in	in	ADP
admet-394	271	8	caenorhabditis	caenorhabditis	ADJ
admet-394	271	9	elegans	elegan	NOUN
admet-394	271	10	decreases	decrease	VERB
admet-394	271	11	lifespan	lifespan	ADJ
admet-394	271	12	and	and	CCONJ
admet-394	271	13	increases	increase	VERB
admet-394	271	14	susceptibility	susceptibility	NOUN
admet-394	271	15	to	to	PART
admet-394	271	16	oxidative	oxidative	ADJ
admet-394	271	17	damage	damage	NOUN
admet-394	271	18	,	,	PUNCT
admet-394	271	19	free	free	ADJ
admet-394	271	20	radic	radic	NOUN
admet-394	271	21	res	re	VERB
admet-394	271	22	47	47	NUM
admet-394	271	23	(	(	PUNCT
admet-394	271	24	2013	2013	NUM
admet-394	271	25	)	)	PUNCT
admet-394	271	26	1036	1036	NUM
admet-394	271	27	-	-	SYM
admet-394	271	28	1045	1045	NUM
admet-394	271	29	.	.	PUNCT
admet-394	272	1	[	[	X
admet-394	272	2	30	30	NUM
admet-394	272	3	]	]	X
admet-394	272	4	a.r	a.r	PROPN
admet-394	272	5	.	.	PROPN
admet-394	272	6	burns	burn	NOUN
admet-394	272	7	,	,	PUNCT
admet-394	272	8	i.m	i.m	PROPN
admet-394	272	9	.	.	PROPN
admet-394	272	10	wallace	wallace	PROPN
admet-394	272	11	,	,	PUNCT
admet-394	272	12	j.	j.	PROPN
admet-394	272	13	wildenhain	wildenhain	PROPN
admet-394	272	14	,	,	PUNCT
admet-394	272	15	m.	m.	NOUN
admet-394	272	16	tyers	tyer	NOUN
admet-394	272	17	,	,	PUNCT
admet-394	272	18	g.	g.	PROPN
admet-394	272	19	giaever	giaever	PROPN
admet-394	272	20	,	,	PUNCT
admet-394	272	21	g.d	g.d	PROPN
admet-394	272	22	.	.	PROPN
admet-394	272	23	bader	bader	PROPN
admet-394	272	24	,	,	PUNCT
admet-394	272	25	c.	c.	PROPN
admet-394	272	26	nislow	nislow	PROPN
admet-394	272	27	,	,	PUNCT
admet-394	272	28	s.r	s.r	PROPN
admet-394	272	29	.	.	PROPN
admet-394	272	30	cutler	cutler	PROPN
admet-394	272	31	,	,	PUNCT
admet-394	272	32	p.j	p.j	PROPN
admet-394	272	33	.	.	PROPN
admet-394	272	34	roy	roy	PROPN
admet-394	272	35	.	.	PUNCT
admet-394	273	1	a	a	DET
admet-394	273	2	predictive	predictive	ADJ
admet-394	273	3	model	model	NOUN
admet-394	273	4	for	for	ADP
admet-394	273	5	drug	drug	NOUN
admet-394	273	6	bioaccumulation	bioaccumulation	NOUN
admet-394	273	7	and	and	CCONJ
admet-394	273	8	bioactivity	bioactivity	NOUN
admet-394	273	9	in	in	ADP
admet-394	273	10	caenorhabditis	caenorhabditis	PROPN
admet-394	273	11	elegans	elegans	PROPN
admet-394	273	12	,	,	PUNCT
admet-394	273	13	nat	nat	NOUN
admet-394	273	14	chem	chem	NOUN
admet-394	273	15	biol	biol	NOUN
admet-394	273	16	6	6	NUM
admet-394	273	17	(	(	PUNCT
admet-394	273	18	2010	2010	NUM
admet-394	273	19	)	)	PUNCT
admet-394	273	20	549	549	NUM
admet-394	273	21	-	-	SYM
admet-394	273	22	557	557	NUM
admet-394	273	23	.	.	PUNCT
admet-394	274	1	admet	admet	PROPN
admet-394	274	2	&	&	CCONJ
admet-394	274	3	dmpk	dmpk	PROPN
admet-394	274	4	5(3	5(3	NUM
admet-394	274	5	)	)	PUNCT
admet-394	274	6	(	(	PUNCT
admet-394	274	7	2017	2017	NUM
admet-394	274	8	)	)	PUNCT
admet-394	274	9	146	146	NUM
admet-394	274	10	-	-	SYM
admet-394	274	11	158	158	NUM
admet-394	274	12	oct-1	oct-1	NUM
admet-394	274	13	and	and	CCONJ
admet-394	274	14	oct-2	oct-2	NUM
admet-394	274	15	in	in	ADP
admet-394	274	16	caenorhabditis	caenorhabditis	PROPN
admet-394	274	17	elegans	elegan	NOUN
admet-394	274	18	doi	doi	NOUN
admet-394	274	19	:	:	PUNCT
admet-394	274	20	10.5599	10.5599	NUM
admet-394	274	21	/	/	SYM
admet-394	274	22	admet.5.3.394	admet.5.3.394	X
admet-394	274	23	157	157	NUM
admet-394	274	24	[	[	X
admet-394	274	25	31	31	NUM
admet-394	274	26	]	]	PUNCT
admet-394	274	27	x.	x.	PROPN
admet-394	274	28	wu	wu	PROPN
admet-394	274	29	,	,	PUNCT
admet-394	274	30	y.j	y.j	PROPN
admet-394	274	31	.	.	PROPN
admet-394	274	32	fei	fei	PROPN
admet-394	274	33	,	,	PUNCT
admet-394	274	34	w.	w.	PROPN
admet-394	274	35	huang	huang	PROPN
admet-394	274	36	,	,	PUNCT
admet-394	274	37	c.	c.	PROPN
admet-394	274	38	chancy	chancy	PROPN
admet-394	274	39	,	,	PUNCT
admet-394	274	40	f.h	f.h	PROPN
admet-394	274	41	.	.	PROPN
admet-394	274	42	leibach	leibach	PROPN
admet-394	274	43	,	,	PUNCT
admet-394	274	44	v.	v.	ADP
admet-394	274	45	ganapathy	ganapathy	PROPN
admet-394	274	46	.	.	PUNCT
admet-394	275	1	identity	identity	NOUN
admet-394	275	2	of	of	ADP
admet-394	275	3	the	the	DET
admet-394	275	4	f52f12.1	f52f12.1	NOUN
admet-394	275	5	gene	gene	NOUN
admet-394	275	6	product	product	NOUN
admet-394	275	7	in	in	ADP
admet-394	275	8	caenorhabditis	caenorhabditis	PROPN
admet-394	275	9	elegans	elegan	NOUN
admet-394	275	10	as	as	ADP
admet-394	275	11	an	an	DET
admet-394	275	12	organic	organic	ADJ
admet-394	275	13	cation	cation	NOUN
admet-394	275	14	transporter	transporter	NOUN
admet-394	275	15	,	,	PUNCT
admet-394	275	16	biochim	biochim	PROPN
admet-394	275	17	biophys	biophy	NOUN
admet-394	275	18	acta	acta	PROPN
admet-394	275	19	1418	1418	NUM
admet-394	275	20	(	(	PUNCT
admet-394	275	21	1999	1999	NUM
admet-394	275	22	)	)	PUNCT
admet-394	275	23	239	239	NUM
admet-394	275	24	-	-	SYM
admet-394	275	25	244	244	NUM
admet-394	275	26	.	.	PUNCT
admet-394	276	1	[	[	X
admet-394	276	2	32	32	NUM
admet-394	276	3	]	]	PUNCT
admet-394	276	4	m.	m.	NOUN
admet-394	276	5	aouida	aouida	PROPN
admet-394	276	6	,	,	PUNCT
admet-394	276	7	m.	m.	NOUN
admet-394	276	8	rubio	rubio	PROPN
admet-394	276	9	-	-	PUNCT
admet-394	276	10	texeira	texeira	PROPN
admet-394	276	11	,	,	PUNCT
admet-394	276	12	j.m	j.m	PROPN
admet-394	276	13	.	.	PROPN
admet-394	276	14	thevelein	thevelein	PROPN
admet-394	276	15	,	,	PUNCT
admet-394	276	16	r.	r.	PROPN
admet-394	276	17	poulin	poulin	PROPN
admet-394	276	18	,	,	PUNCT
admet-394	276	19	d.	d.	PROPN
admet-394	276	20	ramotar	ramotar	PROPN
admet-394	276	21	.	.	PUNCT
admet-394	277	1	agp2	agp2	PROPN
admet-394	277	2	,	,	PUNCT
admet-394	277	3	a	a	DET
admet-394	277	4	member	member	NOUN
admet-394	277	5	of	of	ADP
admet-394	277	6	the	the	DET
admet-394	277	7	yeast	yeast	NOUN
admet-394	277	8	amino	amino	NOUN
admet-394	277	9	acid	acid	NOUN
admet-394	277	10	permease	permease	NOUN
admet-394	277	11	family	family	NOUN
admet-394	277	12	,	,	PUNCT
admet-394	277	13	positively	positively	ADV
admet-394	277	14	regulates	regulate	VERB
admet-394	277	15	polyamine	polyamine	NOUN
admet-394	277	16	transport	transport	NOUN
admet-394	277	17	at	at	ADP
admet-394	277	18	the	the	DET
admet-394	277	19	transcriptional	transcriptional	ADJ
admet-394	277	20	level	level	NOUN
admet-394	277	21	,	,	PUNCT
admet-394	277	22	plos	plos	PROPN
admet-394	277	23	one	one	NUM
admet-394	277	24	8	8	NUM
admet-394	277	25	(	(	PUNCT
admet-394	277	26	2013	2013	NUM
admet-394	277	27	)	)	PUNCT
admet-394	277	28	e65717	e65717	NUM
admet-394	277	29	.	.	PUNCT
admet-394	278	1	[	[	X
admet-394	278	2	33	33	NUM
admet-394	278	3	]	]	PUNCT
admet-394	278	4	a.	a.	NOUN
admet-394	278	5	papaluca	papaluca	NOUN
admet-394	278	6	,	,	PUNCT
admet-394	278	7	d.	d.	PROPN
admet-394	278	8	ramotar	ramotar	PROPN
admet-394	278	9	.	.	PUNCT
admet-394	279	1	a	a	DET
admet-394	279	2	novel	novel	ADJ
admet-394	279	3	approach	approach	NOUN
admet-394	279	4	using	use	VERB
admet-394	279	5	c.	c.	PROPN
admet-394	279	6	elegans	elegans	PROPN
admet-394	279	7	dna	dna	PROPN
admet-394	279	8	damage	damage	NOUN
admet-394	279	9	-	-	PUNCT
admet-394	279	10	induced	induce	VERB
admet-394	279	11	apoptosis	apoptosis	NOUN
admet-394	279	12	to	to	PART
admet-394	279	13	characterize	characterize	VERB
admet-394	279	14	the	the	DET
admet-394	279	15	dynamics	dynamic	NOUN
admet-394	279	16	of	of	ADP
admet-394	279	17	uptake	uptake	ADJ
admet-394	279	18	transporters	transporter	NOUN
admet-394	279	19	for	for	ADP
admet-394	279	20	therapeutic	therapeutic	ADJ
admet-394	279	21	drug	drug	NOUN
admet-394	279	22	discoveries	discovery	NOUN
admet-394	279	23	,	,	PUNCT
admet-394	279	24	sci	sci	PROPN
admet-394	279	25	rep	rep	PROPN
admet-394	279	26	6	6	NUM
admet-394	279	27	(	(	PUNCT
admet-394	279	28	2016	2016	NUM
admet-394	279	29	)	)	PUNCT
admet-394	279	30	36026	36026	NUM
admet-394	279	31	.	.	PUNCT
admet-394	280	1	[	[	X
admet-394	280	2	34	34	NUM
admet-394	280	3	]	]	X
admet-394	280	4	l.	l.	PROPN
admet-394	280	5	chen	chen	PROPN
admet-394	280	6	,	,	PUNCT
admet-394	280	7	y.	y.	PROPN
admet-394	280	8	shu	shu	PROPN
admet-394	280	9	,	,	PUNCT
admet-394	280	10	x.	x.	PROPN
admet-394	280	11	liang	liang	PROPN
admet-394	280	12	,	,	PUNCT
admet-394	280	13	e.c	e.c	PROPN
admet-394	280	14	.	.	PROPN
admet-394	280	15	chen	chen	PROPN
admet-394	280	16	,	,	PUNCT
admet-394	280	17	s.w	s.w	PROPN
admet-394	280	18	.	.	PROPN
admet-394	280	19	yee	yee	PROPN
admet-394	280	20	,	,	PUNCT
admet-394	280	21	a.a	a.a	PROPN
admet-394	280	22	.	.	PROPN
admet-394	280	23	zur	zur	PROPN
admet-394	280	24	,	,	PUNCT
admet-394	280	25	s.	s.	PROPN
admet-394	280	26	li	li	PROPN
admet-394	280	27	,	,	PUNCT
admet-394	280	28	l.	l.	PROPN
admet-394	280	29	xu	xu	PROPN
admet-394	280	30	,	,	PUNCT
admet-394	280	31	k.r	k.r	PROPN
admet-394	280	32	.	.	PROPN
admet-394	280	33	keshari	keshari	PROPN
admet-394	280	34	,	,	PUNCT
admet-394	280	35	m.j	m.j	PROPN
admet-394	280	36	.	.	PROPN
admet-394	280	37	lin	lin	PROPN
admet-394	280	38	,	,	PUNCT
admet-394	280	39	h.c	h.c	PROPN
admet-394	280	40	.	.	PROPN
admet-394	280	41	chien	chien	PROPN
admet-394	280	42	,	,	PUNCT
admet-394	280	43	y.	y.	PROPN
admet-394	280	44	zhang	zhang	PROPN
admet-394	280	45	,	,	PUNCT
admet-394	280	46	k.m	k.m	PROPN
admet-394	280	47	.	.	PROPN
admet-394	280	48	morrissey	morrissey	PROPN
admet-394	280	49	,	,	PUNCT
admet-394	280	50	j.	j.	PROPN
admet-394	280	51	liu	liu	PROPN
admet-394	280	52	,	,	PUNCT
admet-394	280	53	j.	j.	PROPN
admet-394	280	54	ostrem	ostrem	PROPN
admet-394	280	55	,	,	PUNCT
admet-394	280	56	n.s	n.s	PROPN
admet-394	280	57	.	.	PROPN
admet-394	280	58	younger	young	ADJ
admet-394	280	59	,	,	PUNCT
admet-394	280	60	j.	j.	PROPN
admet-394	280	61	kurhanewicz	kurhanewicz	PROPN
admet-394	280	62	,	,	PUNCT
admet-394	280	63	k.m	k.m	PROPN
admet-394	280	64	.	.	PROPN
admet-394	280	65	shokat	shokat	PROPN
admet-394	280	66	,	,	PUNCT
admet-394	280	67	k.	k.	PROPN
admet-394	280	68	ashrafi	ashrafi	PROPN
admet-394	280	69	,	,	PUNCT
admet-394	280	70	k.m	k.m	PROPN
admet-394	280	71	.	.	PROPN
admet-394	280	72	giacomini	giacomini	PROPN
admet-394	280	73	.	.	PUNCT
admet-394	280	74	oct1	oct1	PROPN
admet-394	280	75	is	be	AUX
admet-394	280	76	a	a	DET
admet-394	280	77	high	high	ADJ
admet-394	280	78	-	-	PUNCT
admet-394	280	79	capacity	capacity	NOUN
admet-394	280	80	thiamine	thiamine	NOUN
admet-394	280	81	transporter	transporter	NOUN
admet-394	280	82	that	that	PRON
admet-394	280	83	regulates	regulate	VERB
admet-394	280	84	hepatic	hepatic	ADJ
admet-394	280	85	steatosis	steatosis	NOUN
admet-394	280	86	and	and	CCONJ
admet-394	280	87	is	be	AUX
admet-394	280	88	a	a	DET
admet-394	280	89	target	target	NOUN
admet-394	280	90	of	of	ADP
admet-394	280	91	metformin	metformin	NOUN
admet-394	280	92	,	,	PUNCT
admet-394	280	93	proc	proc	PROPN
admet-394	280	94	natl	natl	PROPN
admet-394	280	95	acad	acad	PROPN
admet-394	280	96	sci	sci	PROPN
admet-394	280	97	u	u	PROPN
admet-394	280	98	s	s	PROPN
admet-394	280	99	a	a	DET
admet-394	280	100	111	111	NUM
admet-394	280	101	(	(	PUNCT
admet-394	280	102	2014	2014	NUM
admet-394	280	103	)	)	PUNCT
admet-394	280	104	9983	9983	NUM
admet-394	280	105	-	-	SYM
admet-394	280	106	9988	9988	NUM
admet-394	280	107	.	.	PUNCT
admet-394	281	1	[	[	X
admet-394	281	2	35	35	NUM
admet-394	281	3	]	]	X
admet-394	281	4	m.l	m.l	PROPN
admet-394	281	5	.	.	PROPN
admet-394	281	6	fishel	fishel	PROPN
admet-394	281	7	,	,	PUNCT
admet-394	281	8	x.	x.	PROPN
admet-394	281	9	wu	wu	PROPN
admet-394	281	10	,	,	PUNCT
admet-394	281	11	c.m	c.m	PROPN
admet-394	281	12	.	.	PROPN
admet-394	281	13	devlin	devlin	PROPN
admet-394	281	14	,	,	PUNCT
admet-394	281	15	d.p	d.p	PROPN
admet-394	281	16	.	.	PROPN
admet-394	281	17	logsdon	logsdon	PROPN
admet-394	281	18	,	,	PUNCT
admet-394	281	19	y.	y.	PROPN
admet-394	281	20	jiang	jiang	PROPN
admet-394	281	21	,	,	PUNCT
admet-394	281	22	m.	m.	PROPN
admet-394	281	23	luo	luo	PROPN
admet-394	281	24	,	,	PUNCT
admet-394	281	25	y.	y.	PROPN
admet-394	281	26	he	he	PRON
admet-394	281	27	,	,	PUNCT
admet-394	281	28	z.	z.	PROPN
admet-394	281	29	yu	yu	PROPN
admet-394	281	30	,	,	PUNCT
admet-394	281	31	y.	y.	PROPN
admet-394	281	32	tong	tong	PROPN
admet-394	281	33	,	,	PUNCT
admet-394	281	34	k.p	k.p	PROPN
admet-394	281	35	.	.	PROPN
admet-394	281	36	lipking	lipking	NOUN
admet-394	281	37	,	,	PUNCT
admet-394	281	38	a.	a.	NOUN
admet-394	281	39	maitra	maitra	PROPN
admet-394	281	40	,	,	PUNCT
admet-394	281	41	n.v	n.v	PROPN
admet-394	281	42	.	.	PROPN
admet-394	281	43	rajeshkumar	rajeshkumar	PROPN
admet-394	281	44	,	,	PUNCT
admet-394	281	45	g.	g.	PROPN
admet-394	281	46	scandura	scandura	PROPN
admet-394	281	47	,	,	PUNCT
admet-394	281	48	m.r	m.r	PROPN
admet-394	281	49	.	.	PROPN
admet-394	281	50	kelley	kelley	PROPN
admet-394	281	51	,	,	PUNCT
admet-394	281	52	m.	m.	PROPN
admet-394	281	53	ivan	ivan	PROPN
admet-394	281	54	.	.	PROPN
admet-394	282	1	apurinic	apurinic	ADJ
admet-394	282	2	/	/	SYM
admet-394	282	3	apyrimidinic	apyrimidinic	ADJ
admet-394	282	4	endonuclease	endonuclease	NOUN
admet-394	282	5	/	/	SYM
admet-394	282	6	redox	redox	NOUN
admet-394	282	7	factor-1	factor-1	PROPN
admet-394	282	8	(	(	PUNCT
admet-394	282	9	ape1	ape1	NOUN
admet-394	282	10	/	/	SYM
admet-394	282	11	ref-1	ref-1	NOUN
admet-394	282	12	)	)	PUNCT
admet-394	282	13	redox	redox	ADJ
admet-394	282	14	function	function	NOUN
admet-394	282	15	negatively	negatively	ADV
admet-394	282	16	regulates	regulate	VERB
admet-394	282	17	nrf2	nrf2	PROPN
admet-394	282	18	,	,	PUNCT
admet-394	282	19	j	j	PROPN
admet-394	282	20	biol	biol	PROPN
admet-394	282	21	chem	chem	NOUN
admet-394	282	22	290	290	NUM
admet-394	282	23	(	(	PUNCT
admet-394	282	24	2015	2015	NUM
admet-394	282	25	)	)	PUNCT
admet-394	282	26	3057	3057	NUM
admet-394	282	27	-	-	SYM
admet-394	282	28	3068	3068	NUM
admet-394	282	29	.	.	PUNCT
admet-394	283	1	[	[	X
admet-394	283	2	36	36	NUM
admet-394	283	3	]	]	X
admet-394	283	4	f.	f.	PROPN
admet-394	283	5	cabreiro	cabreiro	PROPN
admet-394	283	6	,	,	PUNCT
admet-394	283	7	c.	c.	PROPN
admet-394	283	8	au	au	PROPN
admet-394	283	9	,	,	PUNCT
admet-394	283	10	k.y	k.y	PROPN
admet-394	283	11	.	.	PROPN
admet-394	283	12	leung	leung	PROPN
admet-394	283	13	,	,	PUNCT
admet-394	283	14	n.	n.	PROPN
admet-394	283	15	vergara	vergara	PROPN
admet-394	283	16	-	-	PUNCT
admet-394	283	17	irigaray	irigaray	PROPN
admet-394	283	18	,	,	PUNCT
admet-394	283	19	h.m	h.m	PROPN
admet-394	283	20	.	.	PROPN
admet-394	283	21	cocheme	cocheme	PROPN
admet-394	283	22	,	,	PUNCT
admet-394	283	23	t.	t.	PROPN
admet-394	283	24	noori	noori	PROPN
admet-394	283	25	,	,	PUNCT
admet-394	283	26	d.	d.	PROPN
admet-394	283	27	weinkove	weinkove	PROPN
admet-394	283	28	,	,	PUNCT
admet-394	283	29	e.	e.	PROPN
admet-394	283	30	schuster	schuster	PROPN
admet-394	283	31	,	,	PUNCT
admet-394	283	32	n.d	n.d	PROPN
admet-394	283	33	.	.	PROPN
admet-394	283	34	greene	greene	PROPN
admet-394	283	35	,	,	PUNCT
admet-394	283	36	d.	d.	PROPN
admet-394	283	37	gems	gem	NOUN
admet-394	283	38	.	.	PUNCT
admet-394	284	1	metformin	metformin	NOUN
admet-394	284	2	retards	retard	NOUN
admet-394	284	3	aging	age	VERB
admet-394	284	4	in	in	ADP
admet-394	284	5	c.	c.	NOUN
admet-394	284	6	elegans	elegan	NOUN
admet-394	284	7	by	by	ADP
admet-394	284	8	altering	alter	VERB
admet-394	284	9	microbial	microbial	ADJ
admet-394	284	10	folate	folate	NOUN
admet-394	284	11	and	and	CCONJ
admet-394	284	12	methionine	methionine	NOUN
admet-394	284	13	metabolism	metabolism	NOUN
admet-394	284	14	,	,	PUNCT
admet-394	284	15	cell	cell	NOUN
admet-394	284	16	153	153	NUM
admet-394	284	17	(	(	PUNCT
admet-394	284	18	2013	2013	NUM
admet-394	284	19	)	)	PUNCT
admet-394	284	20	228	228	NUM
admet-394	284	21	-	-	SYM
admet-394	284	22	239	239	NUM
admet-394	284	23	.	.	PUNCT
admet-394	285	1	[	[	X
admet-394	285	2	37	37	NUM
admet-394	285	3	]	]	PUNCT
admet-394	285	4	k.	k.	PROPN
admet-394	285	5	hoffmann	hoffmann	PROPN
admet-394	285	6	,	,	PUNCT
admet-394	285	7	f.	f.	PROPN
admet-394	285	8	grafe	grafe	PROPN
admet-394	285	9	,	,	PUNCT
admet-394	285	10	w.	w.	PROPN
admet-394	285	11	wohlrab	wohlrab	PROPN
admet-394	285	12	,	,	PUNCT
admet-394	285	13	r.h	r.h	PROPN
admet-394	285	14	.	.	PROPN
admet-394	285	15	neubert	neubert	PROPN
admet-394	285	16	,	,	PUNCT
admet-394	285	17	m.	m.	NOUN
admet-394	285	18	brandsch	brandsch	PROPN
admet-394	285	19	.	.	PUNCT
admet-394	286	1	functional	functional	ADJ
admet-394	286	2	characterization	characterization	NOUN
admet-394	286	3	of	of	ADP
admet-394	286	4	a	a	DET
admet-394	286	5	high	high	ADJ
admet-394	286	6	-	-	PUNCT
admet-394	286	7	affinity	affinity	NOUN
admet-394	286	8	choline	choline	NOUN
admet-394	286	9	transport	transport	NOUN
admet-394	286	10	system	system	NOUN
admet-394	286	11	in	in	ADP
admet-394	286	12	human	human	ADJ
admet-394	286	13	keratinocytes	keratinocyte	NOUN
admet-394	286	14	,	,	PUNCT
admet-394	286	15	j	j	PROPN
admet-394	286	16	invest	invest	VERB
admet-394	286	17	dermatol	dermatol	NOUN
admet-394	286	18	119	119	NUM
admet-394	286	19	(	(	PUNCT
admet-394	286	20	2002	2002	NUM
admet-394	286	21	)	)	PUNCT
admet-394	286	22	118121	118121	NUM
admet-394	286	23	.	.	PUNCT
admet-394	287	1	[	[	X
admet-394	287	2	38	38	NUM
admet-394	287	3	]	]	PUNCT
admet-394	287	4	a.	a.	NOUN
admet-394	287	5	gartner	gartner	PROPN
admet-394	287	6	,	,	PUNCT
admet-394	287	7	p.r	p.r	PROPN
admet-394	287	8	.	.	PROPN
admet-394	287	9	boag	boag	PROPN
admet-394	287	10	,	,	PUNCT
admet-394	287	11	t.k	t.k	PROPN
admet-394	287	12	.	.	PROPN
admet-394	287	13	blackwell	blackwell	PROPN
admet-394	287	14	.	.	PUNCT
admet-394	288	1	germline	germline	NOUN
admet-394	288	2	survival	survival	NOUN
admet-394	288	3	and	and	CCONJ
admet-394	288	4	apoptosis	apoptosis	NOUN
admet-394	288	5	,	,	PUNCT
admet-394	288	6	wormbook	wormbook	NOUN
admet-394	288	7	(	(	PUNCT
admet-394	288	8	2008	2008	NUM
admet-394	288	9	)	)	PUNCT
admet-394	288	10	1	1	NUM
admet-394	288	11	-	-	SYM
admet-394	288	12	20	20	NUM
admet-394	288	13	.	.	PUNCT
admet-394	289	1	[	[	X
admet-394	289	2	39	39	NUM
admet-394	289	3	]	]	PUNCT
admet-394	289	4	h.	h.	PROPN
admet-394	289	5	lans	lans	PROPN
admet-394	289	6	,	,	PUNCT
admet-394	289	7	w.	w.	PROPN
admet-394	289	8	vermeulen	vermeulen	PROPN
admet-394	289	9	.	.	PUNCT
admet-394	290	1	tissue	tissue	NOUN
admet-394	290	2	specific	specific	ADJ
admet-394	290	3	response	response	NOUN
admet-394	290	4	to	to	ADP
admet-394	290	5	dna	dna	PROPN
admet-394	290	6	damage	damage	NOUN
admet-394	290	7	:	:	PUNCT
admet-394	290	8	c.	c.	NOUN
admet-394	290	9	elegans	elegan	NOUN
admet-394	290	10	as	as	ADP
admet-394	290	11	role	role	NOUN
admet-394	290	12	model	model	NOUN
admet-394	290	13	,	,	PUNCT
admet-394	290	14	dna	dna	PROPN
admet-394	290	15	repair	repair	NOUN
admet-394	290	16	(	(	PUNCT
admet-394	290	17	amst	amst	NOUN
admet-394	290	18	)	)	PUNCT
admet-394	290	19	32	32	NUM
admet-394	290	20	(	(	PUNCT
admet-394	290	21	2015	2015	NUM
admet-394	290	22	)	)	PUNCT
admet-394	290	23	141	141	NUM
admet-394	290	24	-	-	SYM
admet-394	290	25	148	148	NUM
admet-394	290	26	.	.	PUNCT
admet-394	291	1	[	[	X
admet-394	291	2	40	40	NUM
admet-394	291	3	]	]	X
admet-394	291	4	h.r	h.r	PROPN
admet-394	291	5	.	.	PROPN
admet-394	291	6	horvitz	horvitz	PROPN
admet-394	291	7	.	.	PUNCT
admet-394	292	1	genetic	genetic	ADJ
admet-394	292	2	control	control	NOUN
admet-394	292	3	of	of	ADP
admet-394	292	4	programmed	program	VERB
admet-394	292	5	cell	cell	NOUN
admet-394	292	6	death	death	NOUN
admet-394	292	7	in	in	ADP
admet-394	292	8	the	the	DET
admet-394	292	9	nematode	nematode	ADJ
admet-394	292	10	caenorhabditis	caenorhabditis	NOUN
admet-394	292	11	elegans	elegan	NOUN
admet-394	292	12	,	,	PUNCT
admet-394	292	13	cancer	cancer	NOUN
admet-394	292	14	res	re	NOUN
admet-394	292	15	59	59	NUM
admet-394	292	16	(	(	PUNCT
admet-394	292	17	1999	1999	NUM
admet-394	292	18	)	)	PUNCT
admet-394	292	19	1701s-1706s	1701s-1706s	NUM
admet-394	292	20	.	.	PUNCT
admet-394	293	1	[	[	X
admet-394	293	2	41	41	NUM
admet-394	293	3	]	]	X
admet-394	293	4	a.l	a.l	PROPN
admet-394	293	5	.	.	PROPN
admet-394	293	6	craig	craig	PROPN
admet-394	293	7	,	,	PUNCT
admet-394	293	8	s.c	s.c	PROPN
admet-394	293	9	.	.	PROPN
admet-394	293	10	moser	moser	PROPN
admet-394	293	11	,	,	PUNCT
admet-394	293	12	a.p	a.p	PROPN
admet-394	293	13	.	.	PROPN
admet-394	293	14	bailly	bailly	PROPN
admet-394	293	15	,	,	PUNCT
admet-394	293	16	a.	a.	PROPN
admet-394	293	17	gartner	gartner	PROPN
admet-394	293	18	.	.	PUNCT
admet-394	294	1	methods	method	NOUN
admet-394	294	2	for	for	ADP
admet-394	294	3	studying	study	VERB
admet-394	294	4	the	the	DET
admet-394	294	5	dna	dna	PROPN
admet-394	294	6	damage	damage	NOUN
admet-394	294	7	response	response	NOUN
admet-394	294	8	in	in	ADP
admet-394	294	9	the	the	DET
admet-394	294	10	caenorhabdatis	caenorhabdatis	ADJ
admet-394	294	11	elegans	elegan	NOUN
admet-394	294	12	germ	germ	NOUN
admet-394	294	13	line	line	NOUN
admet-394	294	14	,	,	PUNCT
admet-394	294	15	methods	method	NOUN
admet-394	294	16	cell	cell	VERB
admet-394	294	17	biol	biol	NOUN
admet-394	294	18	107	107	NUM
admet-394	294	19	(	(	PUNCT
admet-394	294	20	2012	2012	NUM
admet-394	294	21	)	)	PUNCT
admet-394	294	22	321	321	NUM
admet-394	294	23	-	-	SYM
admet-394	294	24	352	352	NUM
admet-394	294	25	.	.	PUNCT
admet-394	295	1	[	[	X
admet-394	295	2	42	42	NUM
admet-394	295	3	]	]	X
admet-394	295	4	t.l	t.l	PROPN
admet-394	295	5	.	.	PROPN
admet-394	295	6	gumienny	gumienny	PROPN
admet-394	295	7	,	,	PUNCT
admet-394	295	8	e.	e.	PROPN
admet-394	295	9	lambie	lambie	PROPN
admet-394	295	10	,	,	PUNCT
admet-394	295	11	e.	e.	PROPN
admet-394	295	12	hartwieg	hartwieg	PROPN
admet-394	295	13	,	,	PUNCT
admet-394	295	14	h.r	h.r	PROPN
admet-394	295	15	.	.	PROPN
admet-394	295	16	horvitz	horvitz	PROPN
admet-394	295	17	,	,	PUNCT
admet-394	295	18	m.o	m.o	PROPN
admet-394	295	19	.	.	PROPN
admet-394	295	20	hengartner	hengartner	PROPN
admet-394	295	21	.	.	PUNCT
admet-394	296	1	genetic	genetic	ADJ
admet-394	296	2	control	control	NOUN
admet-394	296	3	of	of	ADP
admet-394	296	4	programmed	program	VERB
admet-394	296	5	cell	cell	NOUN
admet-394	296	6	death	death	NOUN
admet-394	296	7	in	in	ADP
admet-394	296	8	the	the	DET
admet-394	296	9	caenorhabditis	caenorhabditis	NOUN
admet-394	296	10	elegans	elegan	NOUN
admet-394	296	11	hermaphrodite	hermaphrodite	PROPN
admet-394	296	12	germline	germline	NOUN
admet-394	296	13	,	,	PUNCT
admet-394	296	14	development	development	NOUN
admet-394	296	15	126	126	NUM
admet-394	296	16	(	(	PUNCT
admet-394	296	17	1999	1999	NUM
admet-394	296	18	)	)	PUNCT
admet-394	296	19	1011	1011	NUM
admet-394	296	20	-	-	SYM
admet-394	296	21	1022	1022	NUM
admet-394	296	22	.	.	PUNCT
admet-394	297	1	[	[	X
admet-394	297	2	43	43	NUM
admet-394	297	3	]	]	PUNCT
admet-394	297	4	a.	a.	NOUN
admet-394	297	5	sendoel	sendoel	PROPN
admet-394	297	6	,	,	PUNCT
admet-394	297	7	s.	s.	PROPN
admet-394	297	8	maida	maida	PROPN
admet-394	297	9	,	,	PUNCT
admet-394	297	10	x.	x.	PROPN
admet-394	297	11	zheng	zheng	PROPN
admet-394	297	12	,	,	PUNCT
admet-394	297	13	y.	y.	PROPN
admet-394	297	14	teo	teo	PROPN
admet-394	297	15	,	,	PUNCT
admet-394	297	16	l.	l.	PROPN
admet-394	297	17	stergiou	stergiou	PROPN
admet-394	297	18	,	,	PUNCT
admet-394	297	19	c.a	c.a	PROPN
admet-394	297	20	.	.	PROPN
admet-394	297	21	rossi	rossi	PROPN
admet-394	297	22	,	,	PUNCT
admet-394	297	23	d.	d.	PROPN
admet-394	297	24	subasic	subasic	PROPN
admet-394	297	25	,	,	PUNCT
admet-394	297	26	s.m	s.m	PROPN
admet-394	297	27	.	.	PROPN
admet-394	297	28	pinto	pinto	PROPN
admet-394	297	29	,	,	PUNCT
admet-394	297	30	j.m	j.m	PROPN
admet-394	297	31	.	.	PROPN
admet-394	297	32	kinchen	kinchen	PROPN
admet-394	297	33	,	,	PUNCT
admet-394	297	34	m.	m.	PROPN
admet-394	297	35	shi	shi	PROPN
admet-394	297	36	,	,	PUNCT
admet-394	297	37	s.	s.	PROPN
admet-394	297	38	boettcher	boettcher	PROPN
admet-394	297	39	,	,	PUNCT
admet-394	297	40	j.n	j.n	PROPN
admet-394	297	41	.	.	PROPN
admet-394	297	42	meyer	meyer	PROPN
admet-394	297	43	,	,	PUNCT
admet-394	297	44	m.g	m.g	PROPN
admet-394	297	45	.	.	PROPN
admet-394	297	46	manz	manz	PROPN
admet-394	297	47	,	,	PUNCT
admet-394	297	48	d.	d.	PROPN
admet-394	297	49	bano	bano	PROPN
admet-394	297	50	,	,	PUNCT
admet-394	297	51	m.o	m.o	PROPN
admet-394	297	52	.	.	PROPN
admet-394	297	53	hengartner	hengartner	PROPN
admet-394	297	54	.	.	PUNCT
admet-394	298	1	depdc1	depdc1	PROPN
admet-394	298	2	/	/	SYM
admet-394	299	1	let-99	let-99	NOUN
admet-394	299	2	participates	participate	VERB
admet-394	299	3	in	in	ADP
admet-394	299	4	an	an	DET
admet-394	299	5	evolutionarily	evolutionarily	ADV
admet-394	299	6	conserved	conserve	VERB
admet-394	299	7	pathway	pathway	NOUN
admet-394	299	8	for	for	ADP
admet-394	299	9	anti	anti	ADJ
admet-394	299	10	-	-	ADJ
admet-394	299	11	tubulin	tubulin	ADJ
admet-394	299	12	drug	drug	NOUN
admet-394	299	13	-	-	PUNCT
admet-394	299	14	induced	induce	VERB
admet-394	299	15	apoptosis	apoptosis	NOUN
admet-394	299	16	,	,	PUNCT
admet-394	299	17	nat	nat	NOUN
admet-394	299	18	cell	cell	NOUN
admet-394	299	19	biol	biol	NOUN
admet-394	299	20	16	16	NUM
admet-394	299	21	(	(	PUNCT
admet-394	299	22	2014	2014	NUM
admet-394	299	23	)	)	PUNCT
admet-394	299	24	812	812	NUM
admet-394	299	25	-	-	SYM
admet-394	299	26	820	820	NUM
admet-394	299	27	.	.	PUNCT
admet-394	300	1	[	[	X
admet-394	300	2	44	44	NUM
admet-394	300	3	]	]	PUNCT
admet-394	300	4	a.	a.	PROPN
admet-394	300	5	roy	roy	PROPN
admet-394	300	6	,	,	PUNCT
admet-394	300	7	a.	a.	PROPN
admet-394	300	8	kucukural	kucukural	PROPN
admet-394	300	9	,	,	PUNCT
admet-394	300	10	y.	y.	PROPN
admet-394	300	11	zhang	zhang	PROPN
admet-394	300	12	.	.	PUNCT
admet-394	301	1	i	i	PROPN
admet-394	301	2	-	-	PUNCT
admet-394	301	3	tasser	tasser	NOUN
admet-394	301	4	:	:	PUNCT
admet-394	301	5	a	a	DET
admet-394	301	6	unified	unified	ADJ
admet-394	301	7	platform	platform	NOUN
admet-394	301	8	for	for	ADP
admet-394	301	9	automated	automate	VERB
admet-394	301	10	protein	protein	NOUN
admet-394	301	11	structure	structure	NOUN
admet-394	301	12	and	and	CCONJ
admet-394	301	13	function	function	NOUN
admet-394	301	14	prediction	prediction	NOUN
admet-394	301	15	,	,	PUNCT
admet-394	301	16	nat	nat	NOUN
admet-394	301	17	protoc	protoc	VERB
admet-394	301	18	5	5	NUM
admet-394	301	19	(	(	PUNCT
admet-394	301	20	2010	2010	NUM
admet-394	301	21	)	)	PUNCT
admet-394	301	22	725	725	NUM
admet-394	301	23	-	-	SYM
admet-394	301	24	738	738	NUM
admet-394	301	25	.	.	PUNCT
admet-394	302	1	[	[	X
admet-394	302	2	45	45	NUM
admet-394	302	3	]	]	PUNCT
admet-394	302	4	l.	l.	PROPN
admet-394	302	5	sun	sun	PROPN
admet-394	302	6	,	,	PUNCT
admet-394	302	7	x.	x.	PROPN
admet-394	302	8	zeng	zeng	PROPN
admet-394	302	9	,	,	PUNCT
admet-394	302	10	c.	c.	PROPN
admet-394	302	11	yan	yan	PROPN
admet-394	302	12	,	,	PUNCT
admet-394	302	13	x.	x.	PROPN
admet-394	302	14	sun	sun	PROPN
admet-394	302	15	,	,	PUNCT
admet-394	302	16	x.	x.	PROPN
admet-394	302	17	gong	gong	PROPN
admet-394	302	18	,	,	PUNCT
admet-394	302	19	y.	y.	PROPN
admet-394	302	20	rao	rao	PROPN
admet-394	302	21	,	,	PUNCT
admet-394	302	22	n.	n.	PROPN
admet-394	302	23	yan	yan	PROPN
admet-394	302	24	.	.	PUNCT
admet-394	303	1	crystal	crystal	NOUN
admet-394	303	2	structure	structure	NOUN
admet-394	303	3	of	of	ADP
admet-394	303	4	a	a	DET
admet-394	303	5	bacterial	bacterial	ADJ
admet-394	303	6	homologue	homologue	NOUN
admet-394	303	7	of	of	ADP
admet-394	303	8	glucose	glucose	NOUN
admet-394	303	9	transporters	transporter	NOUN
admet-394	303	10	glut1	glut1	VERB
admet-394	303	11	-	-	PUNCT
admet-394	303	12	4	4	NUM
admet-394	303	13	,	,	PUNCT
admet-394	303	14	nature	nature	NOUN
admet-394	303	15	490	490	NUM
admet-394	303	16	(	(	PUNCT
admet-394	303	17	2012	2012	NUM
admet-394	303	18	)	)	PUNCT
admet-394	303	19	361	361	NUM
admet-394	303	20	-	-	SYM
admet-394	303	21	366	366	NUM
admet-394	303	22	.	.	PUNCT
admet-394	304	1	[	[	X
admet-394	304	2	46	46	NUM
admet-394	304	3	]	]	X
admet-394	304	4	h.s	h.s	PROPN
admet-394	304	5	.	.	PROPN
admet-394	304	6	lee	lee	PROPN
admet-394	304	7	,	,	PUNCT
admet-394	304	8	y.	y.	PROPN
admet-394	304	9	zhang	zhang	PROPN
admet-394	304	10	.	.	PUNCT
admet-394	305	1	bsp	bsp	NOUN
admet-394	305	2	-	-	PUNCT
admet-394	305	3	slim	slim	NOUN
admet-394	305	4	:	:	PUNCT
admet-394	305	5	a	a	DET
admet-394	305	6	blind	blind	ADJ
admet-394	305	7	low	low	ADJ
admet-394	305	8	-	-	PUNCT
admet-394	305	9	resolution	resolution	NOUN
admet-394	305	10	ligand	ligand	NOUN
admet-394	305	11	-	-	PUNCT
admet-394	305	12	protein	protein	NOUN
admet-394	305	13	docking	docking	NOUN
admet-394	305	14	approach	approach	NOUN
admet-394	305	15	using	use	VERB
admet-394	305	16	predicted	predict	VERB
admet-394	305	17	protein	protein	NOUN
admet-394	305	18	structures	structure	NOUN
admet-394	305	19	,	,	PUNCT
admet-394	305	20	proteins	protein	NOUN
admet-394	305	21	80	80	NUM
admet-394	305	22	(	(	PUNCT
admet-394	305	23	2012	2012	NUM
admet-394	305	24	)	)	PUNCT
admet-394	305	25	93	93	NUM
admet-394	305	26	-	-	SYM
admet-394	305	27	110	110	NUM
admet-394	305	28	.	.	PUNCT
admet-394	306	1	[	[	X
admet-394	306	2	47	47	NUM
admet-394	306	3	]	]	PUNCT
admet-394	306	4	j.	j.	PROPN
admet-394	306	5	yang	yang	PROPN
admet-394	306	6	,	,	PUNCT
admet-394	306	7	a.	a.	PROPN
admet-394	306	8	roy	roy	PROPN
admet-394	306	9	,	,	PUNCT
admet-394	306	10	y.	y.	PROPN
admet-394	306	11	zhang	zhang	PROPN
admet-394	306	12	.	.	PUNCT
admet-394	307	1	protein	protein	NOUN
admet-394	307	2	-	-	PUNCT
admet-394	307	3	ligand	ligand	NOUN
admet-394	307	4	binding	bind	VERB
admet-394	307	5	site	site	NOUN
admet-394	307	6	recognition	recognition	NOUN
admet-394	307	7	using	use	VERB
admet-394	307	8	complementary	complementary	ADJ
admet-394	307	9	bindingspecific	bindingspecific	ADJ
admet-394	307	10	substructure	substructure	NOUN
admet-394	307	11	comparison	comparison	NOUN
admet-394	307	12	and	and	CCONJ
admet-394	307	13	sequence	sequence	NOUN
admet-394	307	14	profile	profile	NOUN
admet-394	307	15	alignment	alignment	NOUN
admet-394	307	16	,	,	PUNCT
admet-394	307	17	bioinformatics	bioinformatics	NOUN
admet-394	307	18	29	29	NUM
admet-394	307	19	(	(	PUNCT
admet-394	307	20	2013	2013	NUM
admet-394	307	21	)	)	PUNCT
admet-394	307	22	25882595	25882595	NUM
admet-394	307	23	.	.	PUNCT
admet-394	308	1	[	[	X
admet-394	308	2	48	48	NUM
admet-394	308	3	]	]	PUNCT
admet-394	308	4	l.	l.	PROPN
admet-394	308	5	lin	lin	PROPN
admet-394	308	6	,	,	PUNCT
admet-394	308	7	s.w	s.w	PROPN
admet-394	308	8	.	.	PROPN
admet-394	308	9	yee	yee	PROPN
admet-394	308	10	,	,	PUNCT
admet-394	308	11	r.b	r.b	PROPN
admet-394	308	12	.	.	PROPN
admet-394	308	13	kim	kim	PROPN
admet-394	308	14	,	,	PUNCT
admet-394	308	15	k.m	k.m	PROPN
admet-394	308	16	.	.	PROPN
admet-394	308	17	giacomini	giacomini	PROPN
admet-394	308	18	.	.	PUNCT
admet-394	309	1	slc	slc	PROPN
admet-394	309	2	transporters	transporter	NOUN
admet-394	309	3	as	as	ADP
admet-394	309	4	therapeutic	therapeutic	ADJ
admet-394	309	5	targets	target	NOUN
admet-394	309	6	:	:	PUNCT
admet-394	309	7	emerging	emerge	VERB
admet-394	309	8	opportunities	opportunity	NOUN
admet-394	309	9	,	,	PUNCT
admet-394	309	10	nat	nat	PROPN
admet-394	309	11	rev	rev	VERB
admet-394	309	12	drug	drug	PROPN
admet-394	309	13	discov	discov	PROPN
admet-394	309	14	14	14	NUM
admet-394	309	15	(	(	PUNCT
admet-394	309	16	2015	2015	NUM
admet-394	309	17	)	)	PUNCT
admet-394	309	18	543	543	NUM
admet-394	309	19	-	-	SYM
admet-394	309	20	560	560	NUM
admet-394	309	21	.	.	PUNCT
admet-394	309	22	dindial	dindial	ADJ
admet-394	309	23	ramotar	ramotar	PROPN
admet-394	309	24	admet	admet	PROPN
admet-394	309	25	&	&	CCONJ
admet-394	309	26	dmpk	dmpk	PROPN
admet-394	309	27	5(3	5(3	NUM
admet-394	309	28	)	)	PUNCT
admet-394	309	29	(	(	PUNCT
admet-394	309	30	2017	2017	NUM
admet-394	309	31	)	)	PUNCT
admet-394	309	32	146	146	NUM
admet-394	309	33	-	-	SYM
admet-394	309	34	158	158	NUM
admet-394	309	35	158	158	NUM
admet-394	309	36	[	[	X
admet-394	309	37	49	49	NUM
admet-394	309	38	]	]	X
admet-394	309	39	e.c	e.c	PROPN
admet-394	309	40	.	.	PROPN
admet-394	309	41	friedberg	friedberg	PROPN
admet-394	309	42	,	,	PUNCT
admet-394	309	43	g.c	g.c	PROPN
admet-394	309	44	.	.	PROPN
admet-394	309	45	walker	walker	PROPN
admet-394	309	46	,	,	PUNCT
admet-394	309	47	w.	w.	PROPN
admet-394	309	48	siede	siede	PROPN
admet-394	309	49	,	,	PUNCT
admet-394	309	50	r.d	r.d	PROPN
admet-394	309	51	.	.	PROPN
admet-394	309	52	wood	wood	PROPN
admet-394	309	53	,	,	PUNCT
admet-394	309	54	r.a	r.a	PROPN
admet-394	309	55	.	.	PROPN
admet-394	309	56	schultz	schultz	PROPN
admet-394	309	57	,	,	PUNCT
admet-394	309	58	t.	t.	PROPN
admet-394	309	59	ellenberger	ellenberger	PROPN
admet-394	309	60	,	,	PUNCT
admet-394	309	61	dna	dna	PROPN
admet-394	309	62	repair	repair	NOUN
admet-394	309	63	and	and	CCONJ
admet-394	309	64	mutagenesis	mutagenesis	NOUN
admet-394	309	65	,	,	PUNCT
admet-394	309	66	asm	asm	NOUN
admet-394	309	67	press	press	NOUN
admet-394	309	68	,	,	PUNCT
admet-394	309	69	washington	washington	PROPN
admet-394	309	70	,	,	PUNCT
admet-394	309	71	d.c	d.c	PROPN
admet-394	309	72	.	.	PROPN
admet-394	309	73	,	,	PUNCT
admet-394	309	74	2006	2006	NUM
admet-394	309	75	.	.	PUNCT
admet-394	310	1	[	[	X
admet-394	310	2	50	50	NUM
admet-394	310	3	]	]	X
admet-394	310	4	a.n	a.n	PROPN
admet-394	310	5	.	.	PROPN
admet-394	310	6	shaik	shaik	PROPN
admet-394	310	7	,	,	PUNCT
admet-394	310	8	d.a	d.a	PROPN
admet-394	310	9	.	.	PROPN
admet-394	310	10	altomare	altomare	PROPN
admet-394	310	11	,	,	PUNCT
admet-394	310	12	l.j	l.j	PROPN
admet-394	310	13	.	.	PROPN
admet-394	310	14	lesko	lesko	PROPN
admet-394	310	15	,	,	PUNCT
admet-394	310	16	m.n	m.n	PROPN
admet-394	310	17	.	.	PROPN
admet-394	310	18	trame	trame	PROPN
admet-394	310	19	.	.	PUNCT
admet-394	311	1	development	development	NOUN
admet-394	311	2	and	and	CCONJ
admet-394	311	3	validation	validation	NOUN
admet-394	311	4	of	of	ADP
admet-394	311	5	a	a	DET
admet-394	311	6	lc	lc	NOUN
admet-394	311	7	-	-	PUNCT
admet-394	311	8	ms	ms	PROPN
admet-394	311	9	/	/	SYM
admet-394	311	10	ms	ms	PROPN
admet-394	311	11	assay	assay	PROPN
admet-394	311	12	for	for	ADP
admet-394	311	13	quantification	quantification	NOUN
admet-394	311	14	of	of	ADP
admet-394	311	15	cisplatin	cisplatin	NOUN
admet-394	311	16	in	in	ADP
admet-394	311	17	rat	rat	NOUN
admet-394	311	18	plasma	plasma	NOUN
admet-394	311	19	and	and	CCONJ
admet-394	311	20	urine	urine	NOUN
admet-394	311	21	,	,	PUNCT
admet-394	311	22	j	j	PROPN
admet-394	311	23	chromatogr	chromatogr	PROPN
admet-394	311	24	b	b	PROPN
admet-394	311	25	analyt	analyt	PROPN
admet-394	311	26	technol	technol	PROPN
admet-394	311	27	biomed	biome	VERB
admet-394	311	28	life	life	NOUN
admet-394	311	29	sci	sci	PROPN
admet-394	311	30	1046	1046	NUM
admet-394	311	31	(	(	PUNCT
admet-394	311	32	2017	2017	NUM
admet-394	311	33	)	)	PUNCT
admet-394	311	34	243	243	NUM
admet-394	311	35	-	-	SYM
admet-394	311	36	249	249	NUM
admet-394	311	37	.	.	PUNCT
admet-394	312	1	[	[	X
admet-394	312	2	51	51	NUM
admet-394	312	3	]	]	PUNCT
admet-394	312	4	x.	x.	PROPN
admet-394	312	5	yang	yang	PROPN
admet-394	312	6	,	,	PUNCT
admet-394	312	7	j.	j.	PROPN
admet-394	312	8	fan	fan	PROPN
admet-394	312	9	,	,	PUNCT
admet-394	312	10	a.a	a.a	PROPN
admet-394	312	11	.	.	PROPN
admet-394	312	12	ishchenko	ishchenko	PROPN
admet-394	312	13	,	,	PUNCT
admet-394	312	14	d.	d.	PROPN
admet-394	312	15	patel	patel	PROPN
admet-394	312	16	,	,	PUNCT
admet-394	312	17	m.k	m.k	PROPN
admet-394	312	18	.	.	PROPN
admet-394	312	19	saparbaev	saparbaev	PROPN
admet-394	312	20	,	,	PUNCT
admet-394	312	21	d.	d.	PROPN
admet-394	312	22	ramotar	ramotar	PROPN
admet-394	312	23	.	.	PUNCT
admet-394	313	1	functional	functional	ADJ
admet-394	313	2	characterization	characterization	NOUN
admet-394	313	3	of	of	ADP
admet-394	313	4	the	the	DET
admet-394	313	5	caenorhabditis	caenorhabditis	PROPN
admet-394	313	6	elegans	elegans	PROPN
admet-394	313	7	dna	dna	PROPN
admet-394	313	8	repair	repair	NOUN
admet-394	313	9	enzyme	enzyme	NOUN
admet-394	313	10	apn-1	apn-1	ADP
admet-394	313	11	,	,	PUNCT
admet-394	313	12	dna	dna	PROPN
admet-394	313	13	repair	repair	NOUN
admet-394	313	14	(	(	PUNCT
admet-394	313	15	amst	amst	NOUN
admet-394	313	16	)	)	PUNCT
admet-394	313	17	11	11	NUM
admet-394	313	18	(	(	PUNCT
admet-394	313	19	2012	2012	NUM
admet-394	313	20	)	)	PUNCT
admet-394	313	21	811	811	NUM
admet-394	313	22	-	-	SYM
admet-394	313	23	822	822	NUM
admet-394	313	24	.	.	PUNCT
admet-394	314	1	[	[	X
admet-394	314	2	52	52	NUM
admet-394	314	3	]	]	PUNCT
admet-394	314	4	g.	g.	PROPN
admet-394	314	5	minotti	minotti	PROPN
admet-394	314	6	,	,	PUNCT
admet-394	314	7	p.	p.	PROPN
admet-394	314	8	menna	menna	PROPN
admet-394	314	9	,	,	PUNCT
admet-394	314	10	e.	e.	PROPN
admet-394	314	11	salvatorelli	salvatorelli	PROPN
admet-394	314	12	,	,	PUNCT
admet-394	314	13	g.	g.	PROPN
admet-394	314	14	cairo	cairo	PROPN
admet-394	314	15	,	,	PUNCT
admet-394	314	16	l.	l.	PROPN
admet-394	314	17	gianni	gianni	PROPN
admet-394	315	1	.	.	PUNCT
admet-394	315	2	anthracyclines	anthracyclines	PROPN
admet-394	315	3	:	:	PUNCT
admet-394	315	4	molecular	molecular	ADJ
admet-394	315	5	advances	advance	NOUN
admet-394	315	6	and	and	CCONJ
admet-394	315	7	pharmacologic	pharmacologic	ADJ
admet-394	315	8	developments	development	NOUN
admet-394	315	9	in	in	ADP
admet-394	315	10	antitumor	antitumor	PROPN
admet-394	315	11	activity	activity	NOUN
admet-394	315	12	and	and	CCONJ
admet-394	315	13	cardiotoxicity	cardiotoxicity	NOUN
admet-394	315	14	,	,	PUNCT
admet-394	315	15	pharmacol	pharmacol	PROPN
admet-394	315	16	rev	rev	VERB
admet-394	315	17	56	56	NUM
admet-394	315	18	(	(	PUNCT
admet-394	315	19	2004	2004	NUM
admet-394	315	20	)	)	PUNCT
admet-394	315	21	185	185	NUM
admet-394	315	22	-	-	SYM
admet-394	315	23	229	229	NUM
admet-394	315	24	.	.	PUNCT
admet-394	316	1	[	[	X
admet-394	316	2	53	53	NUM
admet-394	316	3	]	]	PUNCT
admet-394	316	4	f.	f.	PROPN
admet-394	316	5	huang	huang	PROPN
admet-394	316	6	,	,	PUNCT
admet-394	316	7	a.v	a.v	PROPN
admet-394	316	8	.	.	PROPN
admet-394	316	9	mazin	mazin	PROPN
admet-394	316	10	.	.	PUNCT
admet-394	317	1	a	a	DET
admet-394	317	2	small	small	ADJ
admet-394	317	3	molecule	molecule	NOUN
admet-394	317	4	inhibitor	inhibitor	NOUN
admet-394	317	5	of	of	ADP
admet-394	317	6	human	human	ADJ
admet-394	317	7	rad51	rad51	PROPN
admet-394	317	8	potentiates	potentiate	VERB
admet-394	317	9	breast	breast	NOUN
admet-394	317	10	cancer	cancer	NOUN
admet-394	317	11	cell	cell	NOUN
admet-394	317	12	killing	kill	VERB
admet-394	317	13	by	by	ADP
admet-394	317	14	therapeutic	therapeutic	ADJ
admet-394	317	15	agents	agent	NOUN
admet-394	317	16	in	in	ADP
admet-394	317	17	mouse	mouse	NOUN
admet-394	317	18	xenografts	xenograft	NOUN
admet-394	317	19	,	,	PUNCT
admet-394	317	20	plos	plos	PROPN
admet-394	317	21	one	one	NUM
admet-394	317	22	9	9	NUM
admet-394	317	23	(	(	PUNCT
admet-394	317	24	2014	2014	NUM
admet-394	317	25	)	)	PUNCT
admet-394	317	26	e100993	e100993	PRON
admet-394	317	27	.	.	PUNCT
admet-394	318	1	[	[	X
admet-394	318	2	54	54	NUM
admet-394	318	3	]	]	X
admet-394	318	4	f.	f.	PROPN
admet-394	318	5	huang	huang	PROPN
admet-394	318	6	,	,	PUNCT
admet-394	318	7	a.v	a.v	PROPN
admet-394	318	8	.	.	PROPN
admet-394	318	9	mazin	mazin	PROPN
admet-394	318	10	.	.	PUNCT
admet-394	319	1	targeting	target	VERB
admet-394	319	2	the	the	DET
admet-394	319	3	homologous	homologous	ADJ
admet-394	319	4	recombination	recombination	NOUN
admet-394	319	5	pathway	pathway	NOUN
admet-394	319	6	by	by	ADP
admet-394	319	7	small	small	ADJ
admet-394	319	8	molecule	molecule	NOUN
admet-394	319	9	modulators	modulator	NOUN
admet-394	319	10	,	,	PUNCT
admet-394	319	11	bioorg	bioorg	ADJ
admet-394	319	12	med	med	ADJ
admet-394	319	13	chem	chem	NOUN
admet-394	319	14	lett	lett	NOUN
admet-394	319	15	24	24	NUM
admet-394	319	16	(	(	PUNCT
admet-394	319	17	2014	2014	NUM
admet-394	319	18	)	)	PUNCT
admet-394	319	19	3006	3006	NUM
admet-394	319	20	-	-	SYM
admet-394	319	21	3013	3013	NUM
admet-394	319	22	.	.	PUNCT
admet-394	320	1	[	[	X
admet-394	320	2	55	55	NUM
admet-394	320	3	]	]	X
admet-394	320	4	d.a	d.a	PROPN
admet-394	320	5	.	.	PROPN
admet-394	320	6	alagpulinsa	alagpulinsa	PROPN
admet-394	320	7	,	,	PUNCT
admet-394	320	8	s.	s.	PROPN
admet-394	320	9	ayyadevara	ayyadevara	PROPN
admet-394	320	10	,	,	PUNCT
admet-394	320	11	r.j	r.j	PROPN
admet-394	320	12	.	.	PROPN
admet-394	320	13	shmookler	shmookler	NOUN
admet-394	320	14	reis	reis	NOUN
admet-394	320	15	.	.	PUNCT
admet-394	321	1	a	a	DET
admet-394	321	2	small	small	ADJ
admet-394	321	3	-	-	PUNCT
admet-394	321	4	molecule	molecule	NOUN
admet-394	321	5	inhibitor	inhibitor	NOUN
admet-394	321	6	of	of	ADP
admet-394	321	7	rad51	rad51	ADJ
admet-394	321	8	reduces	reduce	VERB
admet-394	321	9	homologous	homologous	ADJ
admet-394	321	10	recombination	recombination	NOUN
admet-394	321	11	and	and	CCONJ
admet-394	321	12	sensitizes	sensitize	VERB
admet-394	321	13	multiple	multiple	ADJ
admet-394	321	14	myeloma	myeloma	NOUN
admet-394	321	15	cells	cell	NOUN
admet-394	321	16	to	to	ADP
admet-394	321	17	doxorubicin	doxorubicin	PROPN
admet-394	321	18	,	,	PUNCT
admet-394	321	19	front	front	ADJ
admet-394	321	20	oncol	oncol	ADJ
admet-394	321	21	4	4	NUM
admet-394	321	22	(	(	PUNCT
admet-394	321	23	2014	2014	NUM
admet-394	321	24	)	)	PUNCT
admet-394	321	25	289	289	NUM
admet-394	321	26	.	.	PUNCT
admet-394	322	1	[	[	X
admet-394	322	2	56	56	NUM
admet-394	322	3	]	]	PUNCT
admet-394	322	4	a.	a.	NOUN
admet-394	322	5	alpi	alpi	PROPN
admet-394	322	6	,	,	PUNCT
admet-394	322	7	p.	p.	PROPN
admet-394	322	8	pasierbek	pasierbek	PROPN
admet-394	322	9	,	,	PUNCT
admet-394	322	10	a.	a.	NOUN
admet-394	322	11	gartner	gartner	PROPN
admet-394	322	12	,	,	PUNCT
admet-394	322	13	j.	j.	PROPN
admet-394	322	14	loidl	loidl	PROPN
admet-394	322	15	.	.	PUNCT
admet-394	323	1	genetic	genetic	ADJ
admet-394	323	2	and	and	CCONJ
admet-394	323	3	cytological	cytological	ADJ
admet-394	323	4	characterization	characterization	NOUN
admet-394	323	5	of	of	ADP
admet-394	323	6	the	the	DET
admet-394	323	7	recombination	recombination	NOUN
admet-394	323	8	protein	protein	NOUN
admet-394	323	9	rad-51	rad-51	ADP
admet-394	323	10	in	in	ADP
admet-394	323	11	caenorhabditis	caenorhabditis	PROPN
admet-394	323	12	elegans	elegan	NOUN
admet-394	323	13	,	,	PUNCT
admet-394	323	14	chromosoma	chromosoma	NOUN
admet-394	323	15	112	112	NUM
admet-394	323	16	(	(	PUNCT
admet-394	323	17	2003	2003	NUM
admet-394	323	18	)	)	PUNCT
admet-394	323	19	6	6	NUM
admet-394	323	20	-	-	SYM
admet-394	323	21	16	16	NUM
admet-394	323	22	.	.	PUNCT
admet-394	324	1	[	[	X
admet-394	324	2	57	57	NUM
admet-394	324	3	]	]	PUNCT
admet-394	324	4	c.	c.	PROPN
admet-394	324	5	zakaria	zakaria	PROPN
admet-394	324	6	,	,	PUNCT
admet-394	324	7	h.	h.	PROPN
admet-394	324	8	kassahun	kassahun	PROPN
admet-394	324	9	,	,	PUNCT
admet-394	324	10	x.	x.	PROPN
admet-394	324	11	yang	yang	PROPN
admet-394	324	12	,	,	PUNCT
admet-394	324	13	j.c	j.c	PROPN
admet-394	324	14	.	.	PROPN
admet-394	324	15	labbe	labbe	PROPN
admet-394	324	16	,	,	PUNCT
admet-394	324	17	h.	h.	PROPN
admet-394	324	18	nilsen	nilsen	PROPN
admet-394	324	19	,	,	PUNCT
admet-394	324	20	d.	d.	PROPN
admet-394	324	21	ramotar	ramotar	PROPN
admet-394	324	22	.	.	PUNCT
admet-394	325	1	caenorhabditis	caenorhabditis	PROPN
admet-394	325	2	elegans	elegans	PROPN
admet-394	325	3	apn-1	apn-1	DET
admet-394	325	4	plays	play	VERB
admet-394	325	5	a	a	DET
admet-394	325	6	vital	vital	ADJ
admet-394	325	7	role	role	NOUN
admet-394	325	8	in	in	ADP
admet-394	325	9	maintaining	maintain	VERB
admet-394	325	10	genome	genome	NOUN
admet-394	325	11	stability	stability	NOUN
admet-394	325	12	,	,	PUNCT
admet-394	325	13	dna	dna	PROPN
admet-394	325	14	repair	repair	NOUN
admet-394	325	15	(	(	PUNCT
admet-394	325	16	amst	amst	NOUN
admet-394	325	17	)	)	PUNCT
admet-394	325	18	9	9	NUM
admet-394	325	19	(	(	PUNCT
admet-394	325	20	2010	2010	NUM
admet-394	325	21	)	)	PUNCT
admet-394	325	22	169	169	NUM
admet-394	325	23	-	-	SYM
admet-394	325	24	176	176	NUM
admet-394	325	25	.	.	PUNCT
admet-394	326	1	[	[	X
admet-394	326	2	58	58	X
admet-394	326	3	]	]	X
admet-394	326	4	y.	y.	NOUN
admet-394	326	5	popova	popova	PROPN
admet-394	326	6	,	,	PUNCT
admet-394	326	7	p.	p.	NOUN
admet-394	326	8	thayumanavan	thayumanavan	PROPN
admet-394	326	9	,	,	PUNCT
admet-394	326	10	e.	e.	PROPN
admet-394	326	11	lonati	lonati	PROPN
admet-394	326	12	,	,	PUNCT
admet-394	326	13	m.	m.	NOUN
admet-394	326	14	agrochao	agrochao	PROPN
admet-394	326	15	,	,	PUNCT
admet-394	326	16	j.m	j.m	PROPN
admet-394	326	17	.	.	PROPN
admet-394	326	18	thevelein	thevelein	PROPN
admet-394	326	19	.	.	PUNCT
admet-394	327	1	transport	transport	NOUN
admet-394	327	2	and	and	CCONJ
admet-394	327	3	signaling	signal	VERB
admet-394	327	4	through	through	ADP
admet-394	327	5	the	the	DET
admet-394	327	6	phosphate	phosphate	NOUN
admet-394	327	7	-	-	PUNCT
admet-394	327	8	binding	bind	VERB
admet-394	327	9	site	site	NOUN
admet-394	327	10	of	of	ADP
admet-394	327	11	the	the	DET
admet-394	327	12	yeast	yeast	NOUN
admet-394	327	13	pho84	pho84	NOUN
admet-394	327	14	phosphate	phosphate	NOUN
admet-394	327	15	transceptor	transceptor	NOUN
admet-394	327	16	,	,	PUNCT
admet-394	327	17	proc	proc	PROPN
admet-394	327	18	natl	natl	PROPN
admet-394	327	19	acad	acad	PROPN
admet-394	327	20	sci	sci	PROPN
admet-394	327	21	u	u	PROPN
admet-394	327	22	s	s	PROPN
admet-394	327	23	a	a	DET
admet-394	327	24	107	107	NUM
admet-394	327	25	(	(	PUNCT
admet-394	327	26	2010	2010	NUM
admet-394	327	27	)	)	PUNCT
admet-394	327	28	2890	2890	NUM
admet-394	327	29	-	-	SYM
admet-394	327	30	2895	2895	NUM
admet-394	327	31	.	.	PUNCT
admet-394	328	1	[	[	X
admet-394	328	2	59	59	NUM
admet-394	328	3	]	]	PUNCT
admet-394	328	4	j.	j.	PROPN
admet-394	328	5	schothorst	schothorst	PROPN
admet-394	328	6	,	,	PUNCT
admet-394	328	7	h.n	h.n	PROPN
admet-394	328	8	.	.	PROPN
admet-394	328	9	kankipati	kankipati	PROPN
admet-394	328	10	,	,	PUNCT
admet-394	328	11	m.	m.	PROPN
admet-394	328	12	conrad	conrad	PROPN
admet-394	328	13	,	,	PUNCT
admet-394	328	14	d.r	d.r	PROPN
admet-394	328	15	.	.	PROPN
admet-394	328	16	samyn	samyn	PROPN
admet-394	328	17	,	,	PUNCT
admet-394	328	18	g.	g.	PROPN
admet-394	328	19	van	van	PROPN
admet-394	328	20	zeebroeck	zeebroeck	PROPN
admet-394	328	21	,	,	PUNCT
admet-394	328	22	y.	y.	PROPN
admet-394	328	23	popova	popova	PROPN
admet-394	328	24	,	,	PUNCT
admet-394	328	25	m.	m.	NOUN
admet-394	328	26	rubiotexeira	rubiotexeira	PROPN
admet-394	328	27	,	,	PUNCT
admet-394	328	28	b.l	b.l	PROPN
admet-394	328	29	.	.	PROPN
admet-394	328	30	persson	persson	PROPN
admet-394	328	31	,	,	PUNCT
admet-394	328	32	j.m	j.m	PROPN
admet-394	328	33	.	.	PROPN
admet-394	328	34	thevelein	thevelein	PROPN
admet-394	328	35	.	.	PUNCT
admet-394	329	1	yeast	yeast	NOUN
admet-394	329	2	nutrient	nutrient	NOUN
admet-394	329	3	transceptors	transceptor	NOUN
admet-394	329	4	provide	provide	VERB
admet-394	329	5	novel	novel	ADJ
admet-394	329	6	insight	insight	NOUN
admet-394	329	7	in	in	ADP
admet-394	329	8	the	the	DET
admet-394	329	9	functionality	functionality	NOUN
admet-394	329	10	of	of	ADP
admet-394	329	11	membrane	membrane	NOUN
admet-394	329	12	transporters	transporter	NOUN
admet-394	329	13	,	,	PUNCT
admet-394	329	14	curr	curr	PROPN
admet-394	329	15	genet	genet	PROPN
admet-394	329	16	59	59	NUM
admet-394	329	17	(	(	PUNCT
admet-394	329	18	2013	2013	NUM
admet-394	329	19	)	)	PUNCT
admet-394	329	20	197	197	NUM
admet-394	329	21	-	-	SYM
admet-394	329	22	206	206	NUM
admet-394	329	23	.	.	PUNCT
admet-394	330	1	[	[	X
admet-394	330	2	60	60	NUM
admet-394	330	3	]	]	X
admet-394	330	4	r.f	r.f	PROPN
admet-394	330	5	.	.	PROPN
admet-394	330	6	gaber	gaber	PROPN
admet-394	330	7	,	,	PUNCT
admet-394	330	8	k.	k.	PROPN
admet-394	330	9	ottow	ottow	PROPN
admet-394	330	10	,	,	PUNCT
admet-394	330	11	h.a	h.a	PROPN
admet-394	330	12	.	.	PROPN
admet-394	330	13	andersen	andersen	PROPN
admet-394	330	14	,	,	PUNCT
admet-394	330	15	m.c	m.c	PROPN
admet-394	330	16	.	.	PROPN
admet-394	330	17	kielland	kielland	PROPN
admet-394	330	18	-	-	PUNCT
admet-394	330	19	brandt	brandt	PROPN
admet-394	330	20	.	.	PUNCT
admet-394	331	1	constitutive	constitutive	ADJ
admet-394	331	2	and	and	CCONJ
admet-394	331	3	hyperresponsive	hyperresponsive	ADJ
admet-394	331	4	signaling	signaling	NOUN
admet-394	331	5	by	by	ADP
admet-394	331	6	mutant	mutant	ADJ
admet-394	331	7	forms	form	NOUN
admet-394	331	8	of	of	ADP
admet-394	331	9	saccharomyces	saccharomyce	NOUN
admet-394	331	10	cerevisiae	cerevisiae	NOUN
admet-394	331	11	amino	amino	NOUN
admet-394	331	12	acid	acid	NOUN
admet-394	331	13	sensor	sensor	NOUN
admet-394	331	14	ssy1	ssy1	NOUN
admet-394	331	15	,	,	PUNCT
admet-394	331	16	eukaryot	eukaryot	NOUN
admet-394	331	17	cell	cell	NOUN
admet-394	331	18	2	2	NUM
admet-394	331	19	(	(	PUNCT
admet-394	331	20	2003	2003	NUM
admet-394	331	21	)	)	PUNCT
admet-394	331	22	922	922	NUM
admet-394	331	23	-	-	SYM
admet-394	331	24	929	929	NUM
admet-394	331	25	.	.	PUNCT
admet-394	332	1	[	[	X
admet-394	332	2	61	61	NUM
admet-394	332	3	]	]	PUNCT
admet-394	332	4	l.	l.	PROPN
admet-394	332	5	bianchi	bianchi	PROPN
admet-394	332	6	,	,	PUNCT
admet-394	332	7	a.	a.	PROPN
admet-394	332	8	diez	diez	PROPN
admet-394	332	9	-	-	PUNCT
admet-394	332	10	sampedro	sampedro	PROPN
admet-394	332	11	.	.	PUNCT
admet-394	333	1	a	a	DET
admet-394	333	2	single	single	ADJ
admet-394	333	3	amino	amino	NOUN
admet-394	333	4	acid	acid	NOUN
admet-394	333	5	change	change	NOUN
admet-394	333	6	converts	convert	VERB
admet-394	333	7	the	the	DET
admet-394	333	8	sugar	sugar	NOUN
admet-394	333	9	sensor	sensor	NOUN
admet-394	333	10	sglt3	sglt3	ADV
admet-394	333	11	into	into	ADP
admet-394	333	12	a	a	DET
admet-394	333	13	sugar	sugar	NOUN
admet-394	333	14	transporter	transporter	NOUN
admet-394	333	15	,	,	PUNCT
admet-394	333	16	plos	plos	PROPN
admet-394	333	17	one	one	NUM
admet-394	333	18	5	5	NUM
admet-394	333	19	(	(	PUNCT
admet-394	333	20	2010	2010	NUM
admet-394	333	21	)	)	PUNCT
admet-394	333	22	e10241	e10241	NOUN
admet-394	333	23	.	.	PUNCT
admet-394	334	1	[	[	X
admet-394	334	2	62	62	NUM
admet-394	334	3	]	]	PUNCT
admet-394	334	4	s.	s.	PROPN
admet-394	334	5	tumusiime	tumusiime	PROPN
admet-394	334	6	,	,	PUNCT
admet-394	334	7	c.	c.	PROPN
admet-394	334	8	zhang	zhang	PROPN
admet-394	334	9	,	,	PUNCT
admet-394	334	10	m.s	m.s	PROPN
admet-394	334	11	.	.	PROPN
admet-394	334	12	overstreet	overstreet	PROPN
admet-394	334	13	,	,	PUNCT
admet-394	335	1	z.	z.	PROPN
admet-394	335	2	liu	liu	PROPN
admet-394	335	3	.	.	PROPN
admet-394	336	1	differential	differential	ADJ
admet-394	336	2	regulation	regulation	NOUN
admet-394	336	3	of	of	ADP
admet-394	336	4	transcription	transcription	NOUN
admet-394	336	5	factors	factor	NOUN
admet-394	336	6	stp1	stp1	VERB
admet-394	336	7	and	and	CCONJ
admet-394	336	8	stp2	stp2	NOUN
admet-394	336	9	in	in	ADP
admet-394	336	10	the	the	DET
admet-394	336	11	ssy1	ssy1	NOUN
admet-394	336	12	-	-	PUNCT
admet-394	336	13	ptr3	ptr3	NOUN
admet-394	336	14	-	-	PUNCT
admet-394	336	15	ssy5	ssy5	PROPN
admet-394	336	16	amino	amino	NOUN
admet-394	336	17	acid	acid	NOUN
admet-394	336	18	sensing	sense	VERB
admet-394	336	19	pathway	pathway	NOUN
admet-394	336	20	,	,	PUNCT
admet-394	336	21	j	j	PROPN
admet-394	336	22	biol	biol	PROPN
admet-394	336	23	chem	chem	NOUN
admet-394	336	24	286	286	NUM
admet-394	336	25	(	(	PUNCT
admet-394	336	26	2011	2011	NUM
admet-394	336	27	)	)	PUNCT
admet-394	336	28	4620	4620	NUM
admet-394	336	29	-	-	SYM
admet-394	336	30	4631	4631	NUM
admet-394	336	31	.	.	PUNCT
admet-394	337	1	©	©	NOUN
admet-394	337	2	2017	2017	NUM
admet-394	337	3	by	by	ADP
admet-394	337	4	the	the	DET
admet-394	337	5	authors	author	NOUN
admet-394	337	6	;	;	PUNCT
admet-394	337	7	licensee	licensee	PROPN
admet-394	337	8	iapc	iapc	PROPN
admet-394	337	9	,	,	PUNCT
admet-394	337	10	zagreb	zagreb	PROPN
admet-394	337	11	,	,	PUNCT
admet-394	337	12	croatia	croatia	PROPN
admet-394	337	13	.	.	PUNCT
admet-394	338	1	this	this	DET
admet-394	338	2	article	article	NOUN
admet-394	338	3	is	be	AUX
admet-394	338	4	an	an	DET
admet-394	338	5	open	open	ADJ
admet-394	338	6	-	-	PUNCT
admet-394	338	7	access	access	NOUN
admet-394	338	8	article	article	NOUN
admet-394	338	9	distributed	distribute	VERB
admet-394	338	10	under	under	ADP
admet-394	338	11	the	the	DET
admet-394	338	12	terms	term	NOUN
admet-394	338	13	and	and	CCONJ
admet-394	338	14	conditions	condition	NOUN
admet-394	338	15	of	of	ADP
admet-394	338	16	the	the	DET
admet-394	338	17	creative	creative	ADJ
admet-394	338	18	commons	common	NOUN
admet-394	338	19	attribution	attribution	NOUN
admet-394	338	20	license	license	NOUN
admet-394	338	21	(	(	PUNCT
admet-394	338	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-394	338	23	)	)	PUNCT
admet-394	338	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN