id	sid	tid	token	lemma	pos
admet-402	1	1	manuscript	manuscript	PROPN
admet-402	1	2	doi	doi	PROPN
admet-402	1	3	:	:	PUNCT
admet-402	1	4	10.5599	10.5599	NUM
admet-402	1	5	/	/	SYM
admet-402	1	6	admet.5.2.402	admet.5.2.402	PROPN
admet-402	1	7	57	57	NUM
admet-402	1	8	admet	admet	NOUN
admet-402	1	9	&	&	CCONJ
admet-402	1	10	dmpk	dmpk	PROPN
admet-402	1	11	5(2	5(2	NUM
admet-402	1	12	)	)	PUNCT
admet-402	1	13	(	(	PUNCT
admet-402	1	14	2017	2017	NUM
admet-402	1	15	)	)	PUNCT
admet-402	1	16	57	57	NUM
admet-402	1	17	-	-	SYM
admet-402	1	18	58	58	NUM
admet-402	1	19	;	;	PUNCT
admet-402	1	20	doi	doi	NOUN
admet-402	1	21	:	:	PUNCT
admet-402	1	22	10.5599	10.5599	NUM
admet-402	1	23	/	/	SYM
admet-402	1	24	admet.5.2.402	admet.5.2.402	X
admet-402	1	25	open	open	ADJ
admet-402	1	26	access	access	NOUN
admet-402	1	27	:	:	PUNCT
admet-402	1	28	issn	issn	PROPN
admet-402	1	29	:	:	PUNCT
admet-402	1	30	1848	1848	NUM
admet-402	1	31	-	-	SYM
admet-402	1	32	7718	7718	NUM
admet-402	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-402	1	34	editorial	editorial	ADJ
admet-402	1	35	role	role	NOUN
admet-402	1	36	of	of	ADP
admet-402	1	37	drug	drug	NOUN
admet-402	1	38	transporters	transporter	NOUN
admet-402	1	39	in	in	ADP
admet-402	1	40	drug	drug	NOUN
admet-402	1	41	development	development	NOUN
admet-402	1	42	:	:	PUNCT
admet-402	1	43	a	a	DET
admet-402	1	44	qualitative	qualitative	ADJ
admet-402	1	45	and	and	CCONJ
admet-402	1	46	quantitative	quantitative	ADJ
admet-402	1	47	approach	approach	NOUN
admet-402	1	48	sumit	sumit	PROPN
admet-402	1	49	basu	basu	PROPN
admet-402	1	50	,	,	PUNCT
admet-402	1	51	abdul	abdul	PROPN
admet-402	1	52	naveed	naveed	PROPN
admet-402	1	53	shaik	shaik	PROPN
admet-402	1	54	*	*	PROPN
admet-402	1	55	guest	guest	NOUN
admet-402	1	56	editors	editor	NOUN
admet-402	1	57	;	;	PUNCT
admet-402	1	58	admet	admet	PROPN
admet-402	1	59	&	&	CCONJ
admet-402	1	60	dmpk	dmpk	PROPN
admet-402	1	61	center	center	PROPN
admet-402	1	62	for	for	ADP
admet-402	1	63	pharmacometrics	pharmacometric	NOUN
admet-402	1	64	and	and	CCONJ
admet-402	1	65	systems	system	NOUN
admet-402	1	66	pharmacology	pharmacology	NOUN
admet-402	1	67	,	,	PUNCT
admet-402	1	68	university	university	PROPN
admet-402	1	69	of	of	ADP
admet-402	1	70	florida	florida	PROPN
admet-402	1	71	,	,	PUNCT
admet-402	1	72	orlando	orlando	PROPN
admet-402	1	73	,	,	PUNCT
admet-402	1	74	florida	florida	PROPN
admet-402	1	75	.	.	PUNCT
admet-402	2	1	usa	usa	PROPN
admet-402	2	2	*	*	PUNCT
admet-402	2	3	corresponding	correspond	VERB
admet-402	2	4	author	author	NOUN
admet-402	2	5	:	:	PUNCT
admet-402	2	6	e	e	NOUN
admet-402	2	7	-	-	NOUN
admet-402	2	8	mail	mail	NOUN
admet-402	2	9	:	:	PUNCT
admet-402	2	10	naveedshaik@gmail.com	naveedshaik@gmail.com	NUM
admet-402	2	11	;	;	PUNCT
admet-402	2	12	tel	tel	PROPN
admet-402	2	13	.	.	PUNCT
admet-402	2	14	:	:	PUNCT
admet-402	3	1	+1	+1	ADJ
admet-402	3	2	-	-	PUNCT
admet-402	3	3	407	407	NUM
admet-402	3	4	-	-	PUNCT
admet-402	3	5	313	313	NUM
admet-402	3	6	-	-	PUNCT
admet-402	3	7	7009	7009	NUM
admet-402	3	8	;	;	PUNCT
admet-402	3	9	fax	fax	NOUN
admet-402	3	10	:	:	PUNCT
admet-402	3	11	+1	+1	ADJ
admet-402	3	12	-	-	PUNCT
admet-402	3	13	407	407	NUM
admet-402	3	14	-	-	PUNCT
admet-402	3	15	313	313	NUM
admet-402	3	16	-	-	SYM
admet-402	3	17	7030	7030	NUM
admet-402	3	18	received	receive	VERB
admet-402	3	19	:	:	PUNCT
admet-402	3	20	june	june	PROPN
admet-402	3	21	21	21	NUM
admet-402	3	22	,	,	PUNCT
admet-402	3	23	2017	2017	NUM
admet-402	3	24	;	;	PUNCT
admet-402	3	25	published	publish	VERB
admet-402	3	26	:	:	PUNCT
admet-402	3	27	june	june	PROPN
admet-402	3	28	22	22	NUM
admet-402	3	29	,	,	PUNCT
admet-402	3	30	2017	2017	NUM
admet-402	3	31	through	through	ADP
admet-402	3	32	last	last	ADJ
admet-402	3	33	two	two	NUM
admet-402	3	34	decades	decade	NOUN
admet-402	3	35	,	,	PUNCT
admet-402	3	36	transporters	transporter	NOUN
admet-402	3	37	have	have	AUX
admet-402	3	38	been	be	AUX
admet-402	3	39	recognized	recognize	VERB
admet-402	3	40	as	as	ADP
admet-402	3	41	one	one	NUM
admet-402	3	42	of	of	ADP
admet-402	3	43	the	the	DET
admet-402	3	44	important	important	ADJ
admet-402	3	45	elements	element	NOUN
admet-402	3	46	which	which	PRON
admet-402	3	47	plays	play	VERB
admet-402	3	48	an	an	DET
admet-402	3	49	important	important	ADJ
admet-402	3	50	role	role	NOUN
admet-402	3	51	to	to	PART
admet-402	3	52	regulate	regulate	VERB
admet-402	3	53	the	the	DET
admet-402	3	54	adme	adme	NOUN
admet-402	3	55	(	(	PUNCT
admet-402	3	56	absorption	absorption	NOUN
admet-402	3	57	,	,	PUNCT
admet-402	3	58	distribution	distribution	NOUN
admet-402	3	59	,	,	PUNCT
admet-402	3	60	metabolism	metabolism	NOUN
admet-402	3	61	and	and	CCONJ
admet-402	3	62	excretion	excretion	NOUN
admet-402	3	63	)	)	PUNCT
admet-402	3	64	properties	property	NOUN
admet-402	3	65	of	of	ADP
admet-402	3	66	drugs	drug	NOUN
admet-402	3	67	and	and	CCONJ
admet-402	3	68	xenobiotics	xenobiotic	NOUN
admet-402	3	69	.	.	PUNCT
admet-402	4	1	to	to	PART
admet-402	4	2	evaluate	evaluate	VERB
admet-402	4	3	the	the	DET
admet-402	4	4	role	role	NOUN
admet-402	4	5	of	of	ADP
admet-402	4	6	the	the	DET
admet-402	4	7	transporters	transporter	NOUN
admet-402	4	8	in	in	ADP
admet-402	4	9	drug	drug	NOUN
admet-402	4	10	development	development	NOUN
admet-402	4	11	,	,	PUNCT
admet-402	4	12	an	an	DET
admet-402	4	13	international	international	ADJ
admet-402	4	14	transporter	transporter	NOUN
admet-402	4	15	consortium	consortium	NOUN
admet-402	4	16	(	(	PUNCT
admet-402	4	17	itc	itc	PROPN
admet-402	4	18	)	)	PUNCT
admet-402	4	19	discussed	discuss	VERB
admet-402	4	20	about	about	ADP
admet-402	4	21	the	the	DET
admet-402	4	22	identification	identification	NOUN
admet-402	4	23	of	of	ADP
admet-402	4	24	the	the	DET
admet-402	4	25	clinically	clinically	ADV
admet-402	4	26	relevant	relevant	ADJ
admet-402	4	27	transporters	transporter	NOUN
admet-402	4	28	,	,	PUNCT
admet-402	4	29	application	application	NOUN
admet-402	4	30	of	of	ADP
admet-402	4	31	these	these	DET
admet-402	4	32	transporters	transporter	NOUN
admet-402	4	33	in	in	ADP
admet-402	4	34	different	different	ADJ
admet-402	4	35	drug	drug	NOUN
admet-402	4	36	-	-	PUNCT
admet-402	4	37	drug	drug	NOUN
admet-402	4	38	interaction	interaction	NOUN
admet-402	4	39	(	(	PUNCT
admet-402	4	40	ddi	ddi	PROPN
admet-402	4	41	)	)	PUNCT
admet-402	4	42	studies	study	NOUN
admet-402	4	43	and	and	CCONJ
admet-402	4	44	the	the	DET
admet-402	4	45	different	different	ADJ
admet-402	4	46	criteria	criterion	NOUN
admet-402	4	47	to	to	PART
admet-402	4	48	determine	determine	VERB
admet-402	4	49	whether	whether	SCONJ
admet-402	4	50	additional	additional	ADJ
admet-402	4	51	ddi	ddi	ADJ
admet-402	4	52	studies	study	NOUN
admet-402	4	53	are	be	AUX
admet-402	4	54	required	require	VERB
admet-402	4	55	.	.	PUNCT
admet-402	5	1	owing	owe	VERB
admet-402	5	2	to	to	ADP
admet-402	5	3	the	the	DET
admet-402	5	4	increase	increase	NOUN
admet-402	5	5	of	of	ADP
admet-402	5	6	transporter	transporter	NOUN
admet-402	5	7	research	research	NOUN
admet-402	5	8	studies	study	NOUN
admet-402	5	9	in	in	ADP
admet-402	5	10	the	the	DET
admet-402	5	11	last	last	ADJ
admet-402	5	12	decade	decade	NOUN
admet-402	5	13	and	and	CCONJ
admet-402	5	14	the	the	DET
admet-402	5	15	emphasis	emphasis	NOUN
admet-402	5	16	of	of	ADP
admet-402	5	17	the	the	DET
admet-402	5	18	transporter	transporter	NOUN
admet-402	5	19	mediated	mediate	VERB
admet-402	5	20	ddi	ddi	NOUN
admet-402	5	21	by	by	ADP
admet-402	5	22	different	different	ADJ
admet-402	5	23	regulatory	regulatory	ADJ
admet-402	5	24	agencies	agency	NOUN
admet-402	5	25	(	(	PUNCT
admet-402	5	26	fda	fda	PROPN
admet-402	5	27	,	,	PUNCT
admet-402	5	28	ema	ema	PROPN
admet-402	5	29	and	and	CCONJ
admet-402	5	30	pmda	pmda	ADJ
admet-402	5	31	)	)	PUNCT
admet-402	5	32	,	,	PUNCT
admet-402	5	33	the	the	DET
admet-402	5	34	incorporation	incorporation	NOUN
admet-402	5	35	of	of	ADP
admet-402	5	36	transporter	transporter	NOUN
admet-402	5	37	related	relate	VERB
admet-402	5	38	information	information	NOUN
admet-402	5	39	in	in	ADP
admet-402	5	40	the	the	DET
admet-402	5	41	different	different	ADJ
admet-402	5	42	drug	drug	NOUN
admet-402	5	43	“	"	PUNCT
admet-402	5	44	label	label	NOUN
admet-402	5	45	”	"	PUNCT
admet-402	5	46	has	have	AUX
admet-402	5	47	increased	increase	VERB
admet-402	5	48	from	from	ADP
admet-402	5	49	24	24	NUM
admet-402	5	50	%	%	NOUN
admet-402	5	51	to	to	ADP
admet-402	5	52	56	56	NUM
admet-402	5	53	%	%	NOUN
admet-402	5	54	within	within	ADP
admet-402	5	55	five	five	NUM
admet-402	5	56	years	year	NOUN
admet-402	5	57	.	.	PUNCT
admet-402	6	1	in	in	ADP
admet-402	6	2	addition	addition	NOUN
admet-402	6	3	,	,	PUNCT
admet-402	6	4	the	the	DET
admet-402	6	5	transporter	transporter	NOUN
admet-402	6	6	related	relate	VERB
admet-402	6	7	post	post	NOUN
admet-402	6	8	marketing	marketing	NOUN
admet-402	6	9	studies	study	NOUN
admet-402	6	10	became	become	VERB
admet-402	6	11	quite	quite	ADV
admet-402	6	12	important	important	ADJ
admet-402	6	13	to	to	PART
admet-402	6	14	address	address	VERB
admet-402	6	15	different	different	ADJ
admet-402	6	16	questions	question	NOUN
admet-402	6	17	regarding	regard	VERB
admet-402	6	18	dose	dose	NOUN
admet-402	6	19	optimization	optimization	NOUN
admet-402	6	20	and	and	CCONJ
admet-402	6	21	in	in	ADP
admet-402	6	22	the	the	DET
admet-402	6	23	revision	revision	NOUN
admet-402	6	24	of	of	ADP
admet-402	6	25	drug	drug	NOUN
admet-402	6	26	product	product	NOUN
admet-402	6	27	labelling	labelling	NOUN
admet-402	6	28	.	.	PUNCT
admet-402	7	1	in	in	ADP
admet-402	7	2	general	general	ADJ
admet-402	7	3	,	,	PUNCT
admet-402	7	4	the	the	DET
admet-402	7	5	role	role	NOUN
admet-402	7	6	of	of	ADP
admet-402	7	7	transporters	transporter	NOUN
admet-402	7	8	varies	vary	VERB
admet-402	7	9	depending	depend	VERB
admet-402	7	10	on	on	ADP
admet-402	7	11	their	their	PRON
admet-402	7	12	function	function	NOUN
admet-402	7	13	and	and	CCONJ
admet-402	7	14	localization	localization	NOUN
admet-402	7	15	within	within	ADP
admet-402	7	16	the	the	DET
admet-402	7	17	gut	gut	NOUN
admet-402	7	18	lumen	luman	NOUN
admet-402	7	19	,	,	PUNCT
admet-402	7	20	liver	liver	NOUN
admet-402	7	21	,	,	PUNCT
admet-402	7	22	kidney	kidney	NOUN
admet-402	7	23	and	and	CCONJ
admet-402	7	24	brain	brain	NOUN
admet-402	7	25	.	.	PUNCT
admet-402	8	1	depending	depend	VERB
admet-402	8	2	on	on	ADP
admet-402	8	3	the	the	DET
admet-402	8	4	directions	direction	NOUN
admet-402	8	5	of	of	ADP
admet-402	8	6	the	the	DET
admet-402	8	7	transport	transport	NOUN
admet-402	8	8	,	,	PUNCT
admet-402	8	9	they	they	PRON
admet-402	8	10	can	can	AUX
admet-402	8	11	be	be	AUX
admet-402	8	12	classified	classify	VERB
admet-402	8	13	as	as	ADP
admet-402	8	14	either	either	CCONJ
admet-402	8	15	efflux	efflux	VERB
admet-402	8	16	or	or	CCONJ
admet-402	8	17	influx	influx	VERB
admet-402	8	18	/	/	SYM
admet-402	8	19	uptake	uptake	NOUN
admet-402	8	20	.	.	PUNCT
admet-402	9	1	usually	usually	ADV
admet-402	9	2	efflux	efflux	VERB
admet-402	9	3	transporters	transporter	NOUN
admet-402	9	4	shuttle	shuttle	NOUN
admet-402	9	5	compounds	compound	VERB
admet-402	9	6	out	out	ADP
admet-402	9	7	of	of	ADP
admet-402	9	8	the	the	DET
admet-402	9	9	cell	cell	NOUN
admet-402	9	10	against	against	ADP
admet-402	9	11	the	the	DET
admet-402	9	12	concentration	concentration	NOUN
admet-402	9	13	gradient	gradient	NOUN
admet-402	9	14	whereas	whereas	SCONJ
admet-402	9	15	the	the	DET
admet-402	9	16	uptake	uptake	ADJ
admet-402	9	17	transporters	transporter	NOUN
admet-402	9	18	direct	direct	ADJ
admet-402	9	19	compounds	compound	NOUN
admet-402	9	20	into	into	ADP
admet-402	9	21	the	the	DET
admet-402	9	22	cells	cell	NOUN
admet-402	9	23	along	along	ADP
admet-402	9	24	the	the	DET
admet-402	9	25	concentration	concentration	NOUN
admet-402	9	26	gradient	gradient	NOUN
admet-402	9	27	.	.	PUNCT
admet-402	10	1	since	since	SCONJ
admet-402	10	2	many	many	ADJ
admet-402	10	3	transporters	transporter	NOUN
admet-402	10	4	have	have	VERB
admet-402	10	5	the	the	DET
admet-402	10	6	ability	ability	NOUN
admet-402	10	7	to	to	PART
admet-402	10	8	recognize	recognize	VERB
admet-402	10	9	more	more	ADJ
admet-402	10	10	than	than	ADP
admet-402	10	11	one	one	NUM
admet-402	10	12	substrate	substrate	NOUN
admet-402	10	13	,	,	PUNCT
admet-402	10	14	different	different	ADJ
admet-402	10	15	types	type	NOUN
admet-402	10	16	of	of	ADP
admet-402	10	17	ddi	ddi	PROPN
admet-402	10	18	have	have	AUX
admet-402	10	19	been	be	AUX
admet-402	10	20	noticed	notice	VERB
admet-402	10	21	due	due	ADP
admet-402	10	22	to	to	ADP
admet-402	10	23	the	the	DET
admet-402	10	24	inhibition	inhibition	NOUN
admet-402	10	25	and	and	CCONJ
admet-402	10	26	induction	induction	NOUN
admet-402	10	27	of	of	ADP
admet-402	10	28	the	the	DET
admet-402	10	29	function	function	NOUN
admet-402	10	30	of	of	ADP
admet-402	10	31	the	the	DET
admet-402	10	32	transporters	transporter	NOUN
admet-402	10	33	.	.	PUNCT
admet-402	11	1	in	in	ADP
admet-402	11	2	addition	addition	NOUN
admet-402	11	3	,	,	PUNCT
admet-402	11	4	many	many	ADJ
admet-402	11	5	transporters	transporter	NOUN
admet-402	11	6	demonstrated	demonstrate	VERB
admet-402	11	7	genetic	genetic	ADJ
admet-402	11	8	polymorphisms	polymorphism	NOUN
admet-402	11	9	which	which	PRON
admet-402	11	10	may	may	AUX
admet-402	11	11	affect	affect	VERB
admet-402	11	12	their	their	PRON
admet-402	11	13	function	function	NOUN
admet-402	11	14	.	.	PUNCT
admet-402	12	1	traditionally	traditionally	ADV
admet-402	12	2	,	,	PUNCT
admet-402	12	3	in	in	ADP
admet-402	12	4	vitro	vitro	X
admet-402	12	5	tools	tool	NOUN
admet-402	12	6	and	and	CCONJ
admet-402	12	7	preclinical	preclinical	ADJ
admet-402	12	8	animal	animal	NOUN
admet-402	12	9	experiments	experiment	NOUN
admet-402	12	10	have	have	AUX
admet-402	12	11	often	often	ADV
admet-402	12	12	been	be	AUX
admet-402	12	13	used	use	VERB
admet-402	12	14	to	to	PART
admet-402	12	15	assess	assess	VERB
admet-402	12	16	the	the	DET
admet-402	12	17	role	role	NOUN
admet-402	12	18	of	of	ADP
admet-402	12	19	efflux	efflux	ADJ
admet-402	12	20	transporters	transporter	NOUN
admet-402	12	21	in	in	ADP
admet-402	12	22	drug	drug	NOUN
admet-402	12	23	development	development	NOUN
admet-402	12	24	.	.	PUNCT
admet-402	13	1	carefully	carefully	ADV
admet-402	13	2	designed	design	VERB
admet-402	13	3	and	and	CCONJ
admet-402	13	4	properly	properly	ADV
admet-402	13	5	planned	plan	VERB
admet-402	13	6	studies	study	NOUN
admet-402	13	7	can	can	AUX
admet-402	13	8	give	give	VERB
admet-402	13	9	a	a	DET
admet-402	13	10	clear	clear	ADJ
admet-402	13	11	understanding	understanding	NOUN
admet-402	13	12	of	of	ADP
admet-402	13	13	the	the	DET
admet-402	13	14	intrinsic	intrinsic	ADJ
admet-402	13	15	functions	function	NOUN
admet-402	13	16	and	and	CCONJ
admet-402	13	17	attributes	attribute	NOUN
admet-402	13	18	of	of	ADP
admet-402	13	19	the	the	DET
admet-402	13	20	study	study	NOUN
admet-402	13	21	.	.	PUNCT
admet-402	14	1	the	the	DET
admet-402	14	2	accumulation	accumulation	NOUN
admet-402	14	3	of	of	ADP
admet-402	14	4	the	the	DET
admet-402	14	5	current	current	ADJ
admet-402	14	6	in	in	ADP
admet-402	14	7	vitro	vitro	X
admet-402	14	8	and	and	CCONJ
admet-402	14	9	preclinical	preclinical	ADJ
admet-402	14	10	animal	animal	NOUN
admet-402	14	11	knowledge	knowledge	NOUN
admet-402	14	12	base	base	NOUN
admet-402	14	13	is	be	AUX
admet-402	14	14	a	a	DET
admet-402	14	15	conscious	conscious	ADJ
admet-402	14	16	effort	effort	NOUN
admet-402	14	17	to	to	PART
admet-402	14	18	link	link	VERB
admet-402	14	19	the	the	DET
admet-402	14	20	clinical	clinical	ADJ
admet-402	14	21	endpoints	endpoint	NOUN
admet-402	14	22	with	with	ADP
admet-402	14	23	the	the	DET
admet-402	14	24	early	early	ADJ
admet-402	14	25	developmental	developmental	ADJ
admet-402	14	26	work	work	NOUN
admet-402	14	27	which	which	PRON
admet-402	14	28	ultimately	ultimately	ADV
admet-402	14	29	will	will	AUX
admet-402	14	30	help	help	VERB
admet-402	14	31	to	to	PART
admet-402	14	32	identify	identify	VERB
admet-402	14	33	the	the	DET
admet-402	14	34	effect	effect	NOUN
admet-402	14	35	of	of	ADP
admet-402	14	36	drug	drug	NOUN
admet-402	14	37	transporters	transporter	NOUN
admet-402	14	38	in	in	ADP
admet-402	14	39	the	the	DET
admet-402	14	40	clinical	clinical	ADJ
admet-402	14	41	settings	setting	NOUN
admet-402	14	42	.	.	PUNCT
admet-402	15	1	however	however	ADV
admet-402	15	2	,	,	PUNCT
admet-402	15	3	owing	owe	VERB
admet-402	15	4	to	to	ADP
admet-402	15	5	the	the	DET
admet-402	15	6	broad	broad	ADJ
admet-402	15	7	substrate	substrate	NOUN
admet-402	15	8	specificity	specificity	NOUN
admet-402	15	9	as	as	ADV
admet-402	15	10	well	well	ADV
admet-402	15	11	as	as	ADP
admet-402	15	12	significant	significant	ADJ
admet-402	15	13	overlap	overlap	NOUN
admet-402	15	14	of	of	ADP
admet-402	15	15	inhibitor	inhibitor	NOUN
admet-402	15	16	specificity	specificity	NOUN
admet-402	15	17	,	,	PUNCT
admet-402	15	18	one	one	PRON
admet-402	15	19	should	should	AUX
admet-402	15	20	always	always	ADV
admet-402	15	21	investigate	investigate	VERB
admet-402	15	22	the	the	DET
admet-402	15	23	experimental	experimental	ADJ
admet-402	15	24	design	design	NOUN
admet-402	15	25	and	and	CCONJ
admet-402	15	26	the	the	DET
admet-402	15	27	results	result	NOUN
admet-402	15	28	to	to	PART
admet-402	15	29	determine	determine	VERB
admet-402	15	30	the	the	DET
admet-402	15	31	combined	combine	VERB
admet-402	15	32	effects	effect	NOUN
admet-402	15	33	of	of	ADP
admet-402	15	34	particular	particular	ADJ
admet-402	15	35	transporters	transporter	NOUN
admet-402	15	36	.	.	PUNCT
admet-402	16	1	similarly	similarly	ADV
admet-402	16	2	,	,	PUNCT
admet-402	16	3	naturally	naturally	ADV
admet-402	16	4	occurring	occur	VERB
admet-402	16	5	genetic	genetic	ADJ
admet-402	16	6	variabilities	variability	NOUN
admet-402	16	7	arising	arise	VERB
admet-402	16	8	from	from	ADP
admet-402	16	9	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-402	16	10	mailto:naveedshaik@gmail.com	mailto:naveedshaik@gmail.com	PROPN
admet-402	16	11	s.	s.	PROPN
admet-402	16	12	basu	basu	PROPN
admet-402	16	13	and	and	CCONJ
admet-402	16	14	a.n	a.n	PROPN
admet-402	16	15	.	.	PROPN
admet-402	16	16	shaik	shaik	PROPN
admet-402	16	17	admet	admet	PROPN
admet-402	16	18	&	&	CCONJ
admet-402	16	19	dmpk	dmpk	PROPN
admet-402	16	20	5(2	5(2	NUM
admet-402	16	21	)	)	PUNCT
admet-402	16	22	(	(	PUNCT
admet-402	16	23	2017	2017	NUM
admet-402	16	24	)	)	PUNCT
admet-402	16	25	57	57	NUM
admet-402	16	26	-	-	SYM
admet-402	16	27	58	58	NUM
admet-402	16	28	58	58	NUM
admet-402	16	29	genetic	genetic	ADJ
admet-402	16	30	polymorphisms	polymorphism	NOUN
admet-402	16	31	can	can	AUX
admet-402	16	32	also	also	ADV
admet-402	16	33	affect	affect	VERB
admet-402	16	34	both	both	DET
admet-402	16	35	drug	drug	NOUN
admet-402	16	36	absorption	absorption	NOUN
admet-402	16	37	and	and	CCONJ
admet-402	16	38	disposition	disposition	NOUN
admet-402	16	39	which	which	PRON
admet-402	16	40	often	often	ADV
admet-402	16	41	results	result	VERB
admet-402	16	42	in	in	ADP
admet-402	16	43	inconclusive	inconclusive	ADJ
admet-402	16	44	results	result	NOUN
admet-402	16	45	.	.	PUNCT
admet-402	17	1	although	although	SCONJ
admet-402	17	2	the	the	DET
admet-402	17	3	lack	lack	NOUN
admet-402	17	4	of	of	ADP
admet-402	17	5	ideal	ideal	ADJ
admet-402	17	6	probes	probe	NOUN
admet-402	17	7	and	and	CCONJ
admet-402	17	8	inhibitors	inhibitor	NOUN
admet-402	17	9	has	have	AUX
admet-402	17	10	confounded	confound	VERB
admet-402	17	11	the	the	DET
admet-402	17	12	transporter	transporter	NOUN
admet-402	17	13	data	datum	NOUN
admet-402	17	14	interpretations	interpretation	NOUN
admet-402	17	15	for	for	ADP
admet-402	17	16	intestinal	intestinal	ADJ
admet-402	17	17	absorption	absorption	NOUN
admet-402	17	18	,	,	PUNCT
admet-402	17	19	the	the	DET
admet-402	17	20	role	role	NOUN
admet-402	17	21	of	of	ADP
admet-402	17	22	efflux	efflux	NOUN
admet-402	17	23	in	in	ADP
admet-402	17	24	other	other	ADJ
admet-402	17	25	organs	organ	NOUN
admet-402	17	26	(	(	PUNCT
admet-402	17	27	blood	blood	NOUN
admet-402	17	28	-	-	PUNCT
admet-402	17	29	brain	brain	NOUN
admet-402	17	30	-	-	PUNCT
admet-402	17	31	barrier	barrier	NOUN
admet-402	17	32	)	)	PUNCT
admet-402	17	33	is	be	AUX
admet-402	17	34	better	well	ADV
admet-402	17	35	understood	understand	VERB
admet-402	17	36	.	.	PUNCT
admet-402	18	1	with	with	ADP
admet-402	18	2	the	the	DET
admet-402	18	3	increasing	increase	VERB
admet-402	18	4	interest	interest	NOUN
admet-402	18	5	in	in	ADP
admet-402	18	6	drug	drug	NOUN
admet-402	18	7	transporters	transporter	NOUN
admet-402	18	8	from	from	ADP
admet-402	18	9	pharmaceutical	pharmaceutical	ADJ
admet-402	18	10	companies	company	NOUN
admet-402	18	11	and	and	CCONJ
admet-402	18	12	regulatory	regulatory	ADJ
admet-402	18	13	authorities	authority	NOUN
admet-402	18	14	alike	alike	ADV
admet-402	18	15	and	and	CCONJ
admet-402	18	16	following	follow	VERB
admet-402	18	17	the	the	DET
admet-402	18	18	success	success	NOUN
admet-402	18	19	of	of	ADP
admet-402	18	20	a	a	DET
admet-402	18	21	previous	previous	ADJ
admet-402	18	22	special	special	ADJ
admet-402	18	23	issue	issue	NOUN
admet-402	18	24	on	on	ADP
admet-402	18	25	drug	drug	NOUN
admet-402	18	26	metabolism	metabolism	NOUN
admet-402	18	27	[	[	X
admet-402	18	28	1	1	NUM
admet-402	18	29	]	]	PUNCT
admet-402	18	30	as	as	ADV
admet-402	18	31	well	well	ADV
admet-402	18	32	as	as	ADP
admet-402	18	33	a	a	DET
admet-402	18	34	special	special	ADJ
admet-402	18	35	issue	issue	NOUN
admet-402	18	36	on	on	ADP
admet-402	18	37	drug	drug	NOUN
admet-402	18	38	transporters	transporter	NOUN
admet-402	18	39	and	and	CCONJ
admet-402	18	40	permeability	permeability	NOUN
admet-402	18	41	(	(	PUNCT
admet-402	18	42	2015	2015	NUM
admet-402	18	43	,	,	PUNCT
admet-402	18	44	volume	volume	NOUN
admet-402	18	45	3	3	NUM
admet-402	18	46	,	,	PUNCT
admet-402	18	47	issue	issue	NOUN
admet-402	18	48	1	1	NUM
admet-402	18	49	)	)	PUNCT
admet-402	18	50	,	,	PUNCT
admet-402	18	51	admet	admet	PROPN
admet-402	18	52	&	&	CCONJ
admet-402	18	53	dmpk	dmpk	PROPN
admet-402	18	54	devoted	devote	VERB
admet-402	18	55	a	a	DET
admet-402	18	56	special	special	ADJ
admet-402	18	57	issue	issue	NOUN
admet-402	18	58	on	on	ADP
admet-402	18	59	“	"	PUNCT
admet-402	18	60	role	role	NOUN
admet-402	18	61	of	of	ADP
admet-402	18	62	drug	drug	NOUN
admet-402	18	63	transporters	transporter	NOUN
admet-402	18	64	in	in	ADP
admet-402	18	65	drug	drug	NOUN
admet-402	18	66	development	development	NOUN
admet-402	18	67	:	:	PUNCT
admet-402	18	68	a	a	DET
admet-402	18	69	qualitative	qualitative	ADJ
admet-402	18	70	and	and	CCONJ
admet-402	18	71	quantitative	quantitative	ADJ
admet-402	18	72	approach	approach	NOUN
admet-402	18	73	”	"	PUNCT
admet-402	18	74	with	with	ADP
admet-402	18	75	the	the	DET
admet-402	18	76	focus	focus	NOUN
admet-402	18	77	to	to	PART
admet-402	18	78	explore	explore	VERB
admet-402	18	79	the	the	DET
admet-402	18	80	current	current	ADJ
admet-402	18	81	trend	trend	NOUN
admet-402	18	82	in	in	ADP
admet-402	18	83	the	the	DET
admet-402	18	84	uses	use	NOUN
admet-402	18	85	of	of	ADP
admet-402	18	86	these	these	DET
admet-402	18	87	transporters	transporter	NOUN
admet-402	18	88	at	at	ADP
admet-402	18	89	various	various	ADJ
admet-402	18	90	stages	stage	NOUN
admet-402	18	91	of	of	ADP
admet-402	18	92	drug	drug	NOUN
admet-402	18	93	discovery	discovery	NOUN
admet-402	18	94	and	and	CCONJ
admet-402	18	95	development	development	NOUN
admet-402	18	96	.	.	PUNCT
admet-402	19	1	we	we	PRON
admet-402	19	2	received	receive	VERB
admet-402	19	3	a	a	DET
admet-402	19	4	few	few	ADJ
admet-402	19	5	original	original	ADJ
admet-402	19	6	articles	article	NOUN
admet-402	19	7	and	and	CCONJ
admet-402	19	8	two	two	NUM
admet-402	19	9	review	review	NOUN
admet-402	19	10	articles	article	NOUN
admet-402	19	11	,	,	PUNCT
admet-402	19	12	which	which	PRON
admet-402	19	13	covered	cover	VERB
admet-402	19	14	various	various	ADJ
admet-402	19	15	areas	area	NOUN
admet-402	19	16	including	include	VERB
admet-402	19	17	,	,	PUNCT
admet-402	19	18	uric	uric	ADJ
admet-402	19	19	acid	acid	NOUN
admet-402	19	20	transporters	transporter	NOUN
admet-402	19	21	and	and	CCONJ
admet-402	19	22	its	its	PRON
admet-402	19	23	inhibitors	inhibitor	NOUN
admet-402	19	24	in	in	ADP
admet-402	19	25	gout	gout	NOUN
admet-402	19	26	,	,	PUNCT
admet-402	19	27	perillyl	perillyl	ADJ
admet-402	19	28	alcohol	alcohol	NOUN
admet-402	19	29	mediated	mediate	VERB
admet-402	19	30	abrogated	abrogate	VERB
admet-402	19	31	membrane	membrane	NOUN
admet-402	19	32	transport	transport	NOUN
admet-402	19	33	in	in	ADP
admet-402	19	34	candida	candida	NOUN
admet-402	19	35	albicans	albican	NOUN
admet-402	19	36	,	,	PUNCT
admet-402	19	37	use	use	NOUN
admet-402	19	38	of	of	ADP
admet-402	19	39	different	different	ADJ
admet-402	19	40	fluorescent	fluorescent	ADJ
admet-402	19	41	organic	organic	ADJ
admet-402	19	42	cations	cation	NOUN
admet-402	19	43	for	for	ADP
admet-402	19	44	screening	screen	VERB
admet-402	19	45	against	against	ADP
admet-402	19	46	oct2	oct2	NOUN
admet-402	19	47	transporters	transporter	NOUN
admet-402	19	48	and	and	CCONJ
admet-402	19	49	expression	expression	NOUN
admet-402	19	50	of	of	ADP
admet-402	19	51	drug	drug	NOUN
admet-402	19	52	transporters	transporter	NOUN
admet-402	19	53	in	in	ADP
admet-402	19	54	human	human	ADJ
admet-402	19	55	skin	skin	NOUN
admet-402	19	56	and	and	CCONJ
admet-402	19	57	its	its	PRON
admet-402	19	58	uses	use	NOUN
admet-402	19	59	in	in	ADP
admet-402	19	60	drug	drug	NOUN
admet-402	19	61	development	development	NOUN
admet-402	19	62	.	.	PUNCT
admet-402	20	1	one	one	NUM
admet-402	20	2	particular	particular	ADJ
admet-402	20	3	submission	submission	NOUN
admet-402	20	4	of	of	ADP
admet-402	20	5	a	a	DET
admet-402	20	6	great	great	ADJ
admet-402	20	7	interest	interest	NOUN
admet-402	20	8	was	be	AUX
admet-402	20	9	“	"	PUNCT
admet-402	20	10	consensus	consensus	NOUN
admet-402	20	11	rank	rank	NOUN
admet-402	20	12	orderings	ordering	NOUN
admet-402	20	13	of	of	ADP
admet-402	20	14	molecular	molecular	ADJ
admet-402	20	15	fingerprints	fingerprint	NOUN
admet-402	20	16	illustrate	illustrate	VERB
admet-402	20	17	the	the	DET
admet-402	20	18	‘	'	PUNCT
admet-402	20	19	most	most	ADV
admet-402	20	20	genuine	genuine	ADJ
admet-402	20	21	’	'	PUNCT
admet-402	20	22	similarities	similarity	NOUN
admet-402	20	23	between	between	ADP
admet-402	20	24	marketed	market	VERB
admet-402	20	25	drugs	drug	NOUN
admet-402	20	26	and	and	CCONJ
admet-402	20	27	small	small	ADJ
admet-402	20	28	endogenous	endogenous	ADJ
admet-402	20	29	human	human	ADJ
admet-402	20	30	metabolites	metabolite	NOUN
admet-402	20	31	,	,	PUNCT
admet-402	20	32	but	but	CCONJ
admet-402	20	33	highlight	highlight	VERB
admet-402	20	34	exogenous	exogenous	ADJ
admet-402	20	35	natural	natural	ADJ
admet-402	20	36	products	product	NOUN
admet-402	20	37	as	as	ADP
admet-402	20	38	the	the	DET
admet-402	20	39	most	most	ADV
admet-402	20	40	important	important	ADJ
admet-402	20	41	‘	'	PUNCT
admet-402	20	42	natural	natural	ADJ
admet-402	20	43	’	'	PUNCT
admet-402	20	44	drug	drug	NOUN
admet-402	20	45	transporter	transporter	NOUN
admet-402	20	46	substrates	substrate	NOUN
admet-402	20	47	”	"	PUNCT
admet-402	20	48	where	where	SCONJ
admet-402	20	49	the	the	DET
admet-402	20	50	authors	author	NOUN
admet-402	20	51	s.	s.	PROPN
admet-402	20	52	o’hagan	o’hagan	PROPN
admet-402	20	53	and	and	CCONJ
admet-402	20	54	d.b	d.b	PROPN
admet-402	20	55	.	.	PROPN
admet-402	20	56	kell	kell	PROPN
admet-402	20	57	brought	bring	VERB
admet-402	20	58	about	about	ADP
admet-402	20	59	the	the	DET
admet-402	20	60	similarities	similarity	NOUN
admet-402	20	61	between	between	ADP
admet-402	20	62	small	small	ADJ
admet-402	20	63	endogenous	endogenous	ADJ
admet-402	20	64	metabolites	metabolite	NOUN
admet-402	20	65	and	and	CCONJ
admet-402	20	66	marketed	market	VERB
admet-402	20	67	drugs	drug	NOUN
admet-402	20	68	.	.	PUNCT
admet-402	21	1	these	these	DET
admet-402	21	2	submissions	submission	NOUN
admet-402	21	3	clearly	clearly	ADV
admet-402	21	4	indicate	indicate	VERB
admet-402	21	5	the	the	DET
admet-402	21	6	utilization	utilization	NOUN
admet-402	21	7	of	of	ADP
admet-402	21	8	various	various	ADJ
admet-402	21	9	drug	drug	NOUN
admet-402	21	10	transporters	transporter	NOUN
admet-402	21	11	at	at	ADP
admet-402	21	12	different	different	ADJ
admet-402	21	13	stages	stage	NOUN
admet-402	21	14	of	of	ADP
admet-402	21	15	drug	drug	NOUN
admet-402	21	16	discovery	discovery	NOUN
admet-402	21	17	and	and	CCONJ
admet-402	21	18	development	development	NOUN
admet-402	21	19	.	.	PUNCT
admet-402	22	1	as	as	SCONJ
admet-402	22	2	there	there	PRON
admet-402	22	3	has	have	AUX
admet-402	22	4	been	be	AUX
admet-402	22	5	significant	significant	ADJ
admet-402	22	6	interest	interest	NOUN
admet-402	22	7	in	in	ADP
admet-402	22	8	this	this	DET
admet-402	22	9	special	special	ADJ
admet-402	22	10	issue	issue	NOUN
admet-402	22	11	focussing	focusse	VERB
admet-402	22	12	on	on	ADP
admet-402	22	13	drug	drug	NOUN
admet-402	22	14	transporters	transporter	NOUN
admet-402	22	15	we	we	PRON
admet-402	22	16	will	will	AUX
admet-402	22	17	follow	follow	VERB
admet-402	22	18	with	with	ADP
admet-402	22	19	a	a	DET
admet-402	22	20	second	second	ADJ
admet-402	22	21	edition	edition	NOUN
admet-402	22	22	of	of	ADP
admet-402	22	23	the	the	DET
admet-402	22	24	special	special	ADJ
admet-402	22	25	issue	issue	NOUN
admet-402	22	26	to	to	PART
admet-402	22	27	accommodate	accommodate	VERB
admet-402	22	28	other	other	ADJ
admet-402	22	29	submissions	submission	NOUN
admet-402	22	30	.	.	PUNCT
admet-402	23	1	references	reference	NOUN
admet-402	23	2	[	[	X
admet-402	23	3	1	1	NUM
admet-402	23	4	]	]	X
admet-402	23	5	a.n	a.n	PROPN
admet-402	23	6	.	.	PROPN
admet-402	23	7	shaik	shaik	PROPN
admet-402	23	8	,	,	PUNCT
admet-402	23	9	changing	change	VERB
admet-402	23	10	trends	trend	NOUN
admet-402	23	11	in	in	ADP
admet-402	23	12	use	use	NOUN
admet-402	23	13	of	of	ADP
admet-402	23	14	hepatocytes	hepatocyte	NOUN
admet-402	23	15	and	and	CCONJ
admet-402	23	16	microsomes	microsome	NOUN
admet-402	23	17	for	for	ADP
admet-402	23	18	evaluating	evaluate	VERB
admet-402	23	19	metabolism	metabolism	NOUN
admet-402	23	20	studies	study	NOUN
admet-402	23	21	in	in	ADP
admet-402	23	22	drug	drug	NOUN
admet-402	23	23	discovery	discovery	NOUN
admet-402	23	24	,	,	PUNCT
admet-402	23	25	admet	admet	NOUN
admet-402	23	26	and	and	CCONJ
admet-402	23	27	dmpk	dmpk	X
admet-402	23	28	4	4	NUM
admet-402	23	29	(	(	PUNCT
admet-402	23	30	2016	2016	NUM
admet-402	23	31	)	)	PUNCT
admet-402	23	32	,	,	PUNCT
admet-402	23	33	60	60	NUM
admet-402	23	34	-	-	SYM
admet-402	23	35	61	61	NUM
admet-402	23	36	.	.	PUNCT
admet-402	24	1	©	©	PROPN
admet-402	24	2	2017	2017	NUM
admet-402	24	3	by	by	ADP
admet-402	24	4	the	the	DET
admet-402	24	5	authors	author	NOUN
admet-402	24	6	;	;	PUNCT
admet-402	24	7	licensee	licensee	PROPN
admet-402	24	8	iapc	iapc	PROPN
admet-402	24	9	,	,	PUNCT
admet-402	24	10	zagreb	zagreb	PROPN
admet-402	24	11	,	,	PUNCT
admet-402	24	12	croatia	croatia	PROPN
admet-402	24	13	.	.	PUNCT
admet-402	25	1	this	this	DET
admet-402	25	2	article	article	NOUN
admet-402	25	3	is	be	AUX
admet-402	25	4	an	an	DET
admet-402	25	5	open	open	ADJ
admet-402	25	6	-	-	PUNCT
admet-402	25	7	access	access	NOUN
admet-402	25	8	article	article	NOUN
admet-402	25	9	distributed	distribute	VERB
admet-402	25	10	under	under	ADP
admet-402	25	11	the	the	DET
admet-402	25	12	terms	term	NOUN
admet-402	25	13	and	and	CCONJ
admet-402	25	14	conditions	condition	NOUN
admet-402	25	15	of	of	ADP
admet-402	25	16	the	the	DET
admet-402	25	17	creative	creative	ADJ
admet-402	25	18	commons	common	NOUN
admet-402	25	19	attribution	attribution	NOUN
admet-402	25	20	license	license	NOUN
admet-402	25	21	(	(	PUNCT
admet-402	25	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-402	25	23	)	)	PUNCT
admet-402	25	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN