id	sid	tid	token	lemma	pos
admet-42	1	1	manuscript	manuscript	PROPN
admet-42	1	2	doi	doi	PROPN
admet-42	1	3	:	:	PUNCT
admet-42	1	4	10.5599	10.5599	NUM
admet-42	1	5	/	/	SYM
admet-42	1	6	admet.2.4.42	admet.2.4.42	PROPN
admet-42	1	7	221	221	NUM
admet-42	1	8	admet	admet	X
admet-42	1	9	&	&	CCONJ
admet-42	1	10	dmpk	dmpk	PROPN
admet-42	1	11	2(4	2(4	NUM
admet-42	1	12	)	)	PUNCT
admet-42	1	13	(	(	PUNCT
admet-42	1	14	2014	2014	NUM
admet-42	1	15	)	)	PUNCT
admet-42	1	16	221	221	NUM
admet-42	1	17	-	-	SYM
admet-42	1	18	234	234	NUM
admet-42	1	19	;	;	PUNCT
admet-42	1	20	doi	doi	NOUN
admet-42	1	21	:	:	PUNCT
admet-42	1	22	10.5599	10.5599	NUM
admet-42	1	23	/	/	SYM
admet-42	1	24	admet.2.4.42	admet.2.4.42	NOUN
admet-42	1	25	open	open	ADJ
admet-42	1	26	access	access	NOUN
admet-42	1	27	:	:	PUNCT
admet-42	1	28	issn	issn	PROPN
admet-42	1	29	:	:	PUNCT
admet-42	1	30	1848	1848	NUM
admet-42	1	31	-	-	SYM
admet-42	1	32	7718	7718	NUM
admet-42	1	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-42	1	34	original	original	ADJ
admet-42	1	35	scientific	scientific	ADJ
admet-42	1	36	paper	paper	NOUN
admet-42	1	37	potential	potential	NOUN
admet-42	1	38	of	of	ADP
admet-42	1	39	imaging	image	VERB
admet-42	1	40	analysis	analysis	NOUN
admet-42	1	41	in	in	ADP
admet-42	1	42	establishing	establish	VERB
admet-42	1	43	skin	skin	NOUN
admet-42	1	44	concentrationdistance	concentrationdistance	NOUN
admet-42	1	45	profiles	profile	NOUN
admet-42	1	46	for	for	ADP
admet-42	1	47	topically	topically	ADV
admet-42	1	48	applied	apply	VERB
admet-42	1	49	fitc	fitc	NOUN
admet-42	1	50	-	-	PUNCT
admet-42	1	51	dextran	dextran	NOUN
admet-42	1	52	4	4	NUM
admet-42	1	53	kda	kda	NOUN
admet-42	1	54	shosho	shosho	PROPN
admet-42	1	55	kijima1	kijima1	PROPN
admet-42	1	56	,	,	PUNCT
admet-42	1	57	ryosuke	ryosuke	PROPN
admet-42	1	58	masaki1	masaki1	PROPN
admet-42	1	59	,	,	PUNCT
admet-42	1	60	wesam	wesam	PROPN
admet-42	1	61	r.	r.	PROPN
admet-42	1	62	kadhum1	kadhum1	PROPN
admet-42	1	63	,	,	PUNCT
admet-42	1	64	hiroaki	hiroaki	PROPN
admet-42	1	65	todo1	todo1	PROPN
admet-42	1	66	,	,	PUNCT
admet-42	1	67	tomomi	tomomi	PROPN
admet-42	1	68	hatanaka2	hatanaka2	PROPN
admet-42	1	69	,	,	PUNCT
admet-42	1	70	kenji	kenji	PROPN
admet-42	1	71	sugibayashi1,	sugibayashi1,	PROPN
admet-42	1	72	1	1	NUM
admet-42	1	73	faculty	faculty	NOUN
admet-42	1	74	of	of	ADP
admet-42	1	75	pharmaceutical	pharmaceutical	NOUN
admet-42	1	76	sciences	science	NOUN
admet-42	1	77	,	,	PUNCT
admet-42	1	78	josai	josai	PROPN
admet-42	1	79	university	university	NOUN
admet-42	1	80	,	,	PUNCT
admet-42	1	81	1	1	NUM
admet-42	1	82	-	-	SYM
admet-42	1	83	1	1	NUM
admet-42	1	84	keyakidai	keyakidai	NOUN
admet-42	1	85	,	,	PUNCT
admet-42	1	86	sakado	sakado	NOUN
admet-42	1	87	,	,	PUNCT
admet-42	1	88	saitama	saitama	PROPN
admet-42	1	89	350	350	NUM
admet-42	1	90	-	-	SYM
admet-42	1	91	0295	0295	NUM
admet-42	1	92	,	,	PUNCT
admet-42	1	93	japan	japan	PROPN
admet-42	1	94	2	2	NUM
admet-42	1	95	institute	institute	NOUN
admet-42	1	96	of	of	ADP
admet-42	1	97	innovative	innovative	ADJ
admet-42	1	98	science	science	NOUN
admet-42	1	99	and	and	CCONJ
admet-42	1	100	technology	technology	NOUN
admet-42	1	101	,	,	PUNCT
admet-42	1	102	medical	medical	ADJ
admet-42	1	103	science	science	NOUN
admet-42	1	104	division	division	NOUN
admet-42	1	105	,	,	PUNCT
admet-42	1	106	tokai	tokai	PROPN
admet-42	1	107	university	university	PROPN
admet-42	1	108	,	,	PUNCT
admet-42	1	109	4	4	NUM
admet-42	1	110	-	-	SYM
admet-42	1	111	1	1	NUM
admet-42	1	112	-	-	SYM
admet-42	1	113	1	1	NUM
admet-42	1	114	kitakaname	kitakaname	NOUN
admet-42	1	115	,	,	PUNCT
admet-42	1	116	hiratsuka	hiratsuka	PROPN
admet-42	1	117	,	,	PUNCT
admet-42	1	118	kanagawa	kanagawa	PROPN
admet-42	1	119	259	259	NUM
admet-42	1	120	-	-	SYM
admet-42	1	121	1292	1292	NUM
admet-42	1	122	,	,	PUNCT
admet-42	1	123	japan	japan	PROPN
admet-42	1	124	corresponding	corresponde	VERB
admet-42	1	125	author	author	NOUN
admet-42	1	126	:	:	PUNCT
admet-42	1	127	e	e	NOUN
admet-42	1	128	-	-	NOUN
admet-42	1	129	mail	mail	NOUN
admet-42	1	130	:	:	PUNCT
admet-42	1	131	sugib@josai.ac.jp	sugib@josai.ac.jp	NOUN
admet-42	1	132	;	;	PUNCT
admet-42	1	133	tel	tel	PROPN
admet-42	1	134	.	.	PUNCT
admet-42	1	135	:	:	PUNCT
admet-42	2	1	049	049	NUM
admet-42	2	2	-	-	PUNCT
admet-42	2	3	271	271	NUM
admet-42	2	4	-	-	SYM
admet-42	2	5	7367	7367	NUM
admet-42	2	6	;	;	PUNCT
admet-42	2	7	fax	fax	NOUN
admet-42	2	8	:	:	PUNCT
admet-42	2	9	049	049	NUM
admet-42	2	10	-	-	PUNCT
admet-42	2	11	271	271	NUM
admet-42	2	12	-	-	SYM
admet-42	2	13	8137	8137	NUM
admet-42	2	14	received	receive	VERB
admet-42	2	15	:	:	PUNCT
admet-42	2	16	may	may	AUX
admet-42	2	17	26	26	NUM
admet-42	2	18	,	,	PUNCT
admet-42	2	19	2014	2014	NUM
admet-42	2	20	;	;	PUNCT
admet-42	2	21	revised	revise	VERB
admet-42	2	22	:	:	PUNCT
admet-42	2	23	july	july	PROPN
admet-42	2	24	06	06	NUM
admet-42	2	25	,	,	PUNCT
admet-42	2	26	2014	2014	NUM
admet-42	2	27	;	;	PUNCT
admet-42	2	28	published	publish	VERB
admet-42	2	29	:	:	PUNCT
admet-42	2	30	january	january	PROPN
admet-42	2	31	09	09	NUM
admet-42	2	32	,	,	PUNCT
admet-42	2	33	2015	2015	NUM
admet-42	2	34	abstract	abstract	NOUN
admet-42	2	35	quantitatively	quantitatively	ADV
admet-42	2	36	determining	determine	VERB
admet-42	2	37	the	the	DET
admet-42	2	38	skin	skin	NOUN
admet-42	2	39	concentration	concentration	NOUN
admet-42	2	40	-	-	PUNCT
admet-42	2	41	distance	distance	NOUN
admet-42	2	42	profiles	profile	NOUN
admet-42	2	43	of	of	ADP
admet-42	2	44	topically	topically	ADV
admet-42	2	45	applied	apply	VERB
admet-42	2	46	drugs	drug	NOUN
admet-42	2	47	is	be	AUX
admet-42	2	48	important	important	ADJ
admet-42	2	49	for	for	ADP
admet-42	2	50	evaluating	evaluate	VERB
admet-42	2	51	their	their	PRON
admet-42	2	52	safety	safety	NOUN
admet-42	2	53	and	and	CCONJ
admet-42	2	54	efficacy	efficacy	NOUN
admet-42	2	55	.	.	PUNCT
admet-42	3	1	the	the	DET
admet-42	3	2	aim	aim	NOUN
admet-42	3	3	of	of	ADP
admet-42	3	4	the	the	DET
admet-42	3	5	present	present	ADJ
admet-42	3	6	study	study	NOUN
admet-42	3	7	was	be	AUX
admet-42	3	8	to	to	PART
admet-42	3	9	quantitatively	quantitatively	ADV
admet-42	3	10	visualize	visualize	VERB
admet-42	3	11	the	the	DET
admet-42	3	12	distribution	distribution	NOUN
admet-42	3	13	of	of	ADP
admet-42	3	14	hydrophilic	hydrophilic	ADJ
admet-42	3	15	drugs	drug	NOUN
admet-42	3	16	through	through	ADP
admet-42	3	17	the	the	DET
admet-42	3	18	skin	skin	NOUN
admet-42	3	19	using	use	VERB
admet-42	3	20	confocal	confocal	ADJ
admet-42	3	21	laser	laser	NOUN
admet-42	3	22	scanning	scan	VERB
admet-42	3	23	microscopy	microscopy	NOUN
admet-42	3	24	(	(	PUNCT
admet-42	3	25	clsm	clsm	X
admet-42	3	26	)	)	PUNCT
admet-42	3	27	in	in	ADP
admet-42	3	28	order	order	NOUN
admet-42	3	29	to	to	PART
admet-42	3	30	obtain	obtain	VERB
admet-42	3	31	skin	skin	NOUN
admet-42	3	32	concentration	concentration	NOUN
admet-42	3	33	-	-	PUNCT
admet-42	3	34	distance	distance	NOUN
admet-42	3	35	profiles	profile	NOUN
admet-42	3	36	.	.	PUNCT
admet-42	4	1	fitc	fitc	NOUN
admet-42	4	2	-	-	PUNCT
admet-42	4	3	dextran	dextran	NOUN
admet-42	4	4	with	with	ADP
admet-42	4	5	a	a	DET
admet-42	4	6	molecular	molecular	ADJ
admet-42	4	7	weight	weight	NOUN
admet-42	4	8	of	of	ADP
admet-42	4	9	approximately	approximately	ADV
admet-42	4	10	4	4	NUM
admet-42	4	11	kda	kda	NOUN
admet-42	4	12	(	(	PUNCT
admet-42	4	13	fd-4	fd-4	NUM
admet-42	4	14	)	)	PUNCT
admet-42	4	15	was	be	AUX
admet-42	4	16	selected	select	VERB
admet-42	4	17	as	as	ADP
admet-42	4	18	the	the	DET
admet-42	4	19	model	model	NOUN
admet-42	4	20	fluorescent	fluorescent	NOUN
admet-42	4	21	drug	drug	NOUN
admet-42	4	22	in	in	ADP
admet-42	4	23	the	the	DET
admet-42	4	24	present	present	ADJ
admet-42	4	25	study	study	NOUN
admet-42	4	26	,	,	PUNCT
admet-42	4	27	and	and	CCONJ
admet-42	4	28	excised	excise	VERB
admet-42	4	29	pig	pig	NOUN
admet-42	4	30	ear	ear	NOUN
admet-42	4	31	skin	skin	NOUN
admet-42	4	32	was	be	AUX
admet-42	4	33	used	use	VERB
admet-42	4	34	.	.	PUNCT
admet-42	5	1	the	the	DET
admet-42	5	2	skin	skin	NOUN
admet-42	5	3	concentration	concentration	NOUN
admet-42	5	4	of	of	ADP
admet-42	5	5	fd-4	fd-4	NOUN
admet-42	5	6	at	at	ADP
admet-42	5	7	each	each	DET
admet-42	5	8	depth	depth	NOUN
admet-42	5	9	of	of	ADP
admet-42	5	10	a	a	DET
admet-42	5	11	skin	skin	NOUN
admet-42	5	12	section	section	NOUN
admet-42	5	13	was	be	AUX
admet-42	5	14	assessed	assess	VERB
admet-42	5	15	by	by	ADP
admet-42	5	16	imaging	image	VERB
admet-42	5	17	analysis	analysis	NOUN
admet-42	5	18	of	of	ADP
admet-42	5	19	the	the	DET
admet-42	5	20	intensity	intensity	NOUN
admet-42	5	21	of	of	ADP
admet-42	5	22	fluorescence	fluorescence	NOUN
admet-42	5	23	.	.	PUNCT
admet-42	6	1	the	the	DET
admet-42	6	2	fd-4	fd-4	NOUN
admet-42	6	3	skin	skin	NOUN
admet-42	6	4	concentration	concentration	NOUN
admet-42	6	5	-	-	PUNCT
admet-42	6	6	distance	distance	NOUN
admet-42	6	7	profile	profile	NOUN
admet-42	6	8	obtained	obtain	VERB
admet-42	6	9	was	be	AUX
admet-42	6	10	analyzed	analyze	VERB
admet-42	6	11	using	use	VERB
admet-42	6	12	fick	fick	PROPN
admet-42	6	13	’s	’s	PART
admet-42	6	14	second	second	ADJ
admet-42	6	15	law	law	NOUN
admet-42	6	16	of	of	ADP
admet-42	6	17	diffusion	diffusion	NOUN
admet-42	6	18	,	,	PUNCT
admet-42	6	19	and	and	CCONJ
admet-42	6	20	was	be	AUX
admet-42	6	21	markedly	markedly	ADV
admet-42	6	22	similar	similar	ADJ
admet-42	6	23	to	to	ADP
admet-42	6	24	that	that	PRON
admet-42	6	25	using	use	VERB
admet-42	6	26	skin	skin	NOUN
admet-42	6	27	permeation	permeation	NOUN
admet-42	6	28	parameters	parameter	NOUN
admet-42	6	29	in	in	ADP
admet-42	6	30	the	the	DET
admet-42	6	31	skin	skin	NOUN
admet-42	6	32	permeation	permeation	NOUN
admet-42	6	33	study	study	NOUN
admet-42	6	34	.	.	PUNCT
admet-42	7	1	these	these	DET
admet-42	7	2	results	result	NOUN
admet-42	7	3	suggest	suggest	VERB
admet-42	7	4	that	that	SCONJ
admet-42	7	5	the	the	DET
admet-42	7	6	present	present	ADJ
admet-42	7	7	clsm	clsm	NOUN
admet-42	7	8	method	method	NOUN
admet-42	7	9	may	may	AUX
admet-42	7	10	be	be	AUX
admet-42	7	11	a	a	DET
admet-42	7	12	promising	promising	ADJ
admet-42	7	13	tool	tool	NOUN
admet-42	7	14	for	for	ADP
admet-42	7	15	quantitatively	quantitatively	ADV
admet-42	7	16	visualizing	visualize	VERB
admet-42	7	17	the	the	DET
admet-42	7	18	concentration	concentration	NOUN
admet-42	7	19	-	-	PUNCT
admet-42	7	20	distance	distance	NOUN
admet-42	7	21	profiles	profile	NOUN
admet-42	7	22	of	of	ADP
admet-42	7	23	drugs	drug	NOUN
admet-42	7	24	through	through	ADP
admet-42	7	25	the	the	DET
admet-42	7	26	skin	skin	NOUN
admet-42	7	27	.	.	PUNCT
admet-42	8	1	keywords	keyword	VERB
admet-42	8	2	confocal	confocal	ADJ
admet-42	8	3	microscopy	microscopy	NOUN
admet-42	8	4	;	;	PUNCT
admet-42	8	5	fitc	fitc	NOUN
admet-42	8	6	-	-	PUNCT
admet-42	8	7	dextran	dextran	NOUN
admet-42	8	8	,	,	PUNCT
admet-42	8	9	dermatopharmacokinetics	dermatopharmacokinetic	NOUN
admet-42	8	10	,	,	PUNCT
admet-42	8	11	skin	skin	NOUN
admet-42	8	12	permeation	permeation	NOUN
admet-42	8	13	introduction	introduction	NOUN
admet-42	8	14	drug	drug	NOUN
admet-42	8	15	delivery	delivery	NOUN
admet-42	8	16	through	through	ADP
admet-42	8	17	the	the	DET
admet-42	8	18	skin	skin	NOUN
admet-42	8	19	remains	remain	VERB
admet-42	8	20	an	an	DET
admet-42	8	21	attractive	attractive	ADJ
admet-42	8	22	and	and	CCONJ
admet-42	8	23	challenging	challenging	ADJ
admet-42	8	24	area	area	NOUN
admet-42	8	25	for	for	ADP
admet-42	8	26	research	research	NOUN
admet-42	8	27	and	and	CCONJ
admet-42	8	28	development	development	NOUN
admet-42	8	29	.	.	PUNCT
admet-42	9	1	most	most	ADJ
admet-42	9	2	of	of	ADP
admet-42	9	3	the	the	DET
admet-42	9	4	drugs	drug	NOUN
admet-42	9	5	contained	contain	VERB
admet-42	9	6	in	in	ADP
admet-42	9	7	transdermal	transdermal	ADJ
admet-42	9	8	delivery	delivery	NOUN
admet-42	9	9	systems	system	NOUN
admet-42	9	10	are	be	AUX
admet-42	9	11	lipophilic	lipophilic	ADJ
admet-42	9	12	with	with	ADP
admet-42	9	13	low	low	ADJ
admet-42	9	14	molecular	molecular	ADJ
admet-42	9	15	weights	weight	NOUN
admet-42	9	16	.	.	PUNCT
admet-42	10	1	however	however	ADV
admet-42	10	2	,	,	PUNCT
admet-42	10	3	various	various	ADJ
admet-42	10	4	chemical	chemical	NOUN
admet-42	10	5	and	and	CCONJ
admet-42	10	6	physical	physical	ADJ
admet-42	10	7	approaches	approach	NOUN
admet-42	10	8	have	have	AUX
admet-42	10	9	been	be	AUX
admet-42	10	10	used	use	VERB
admet-42	10	11	to	to	PART
admet-42	10	12	overcome	overcome	VERB
admet-42	10	13	the	the	DET
admet-42	10	14	barrier	barrier	NOUN
admet-42	10	15	function	function	NOUN
admet-42	10	16	of	of	ADP
admet-42	10	17	the	the	DET
admet-42	10	18	stratum	stratum	NOUN
admet-42	10	19	corneum	corneum	VERB
admet-42	10	20	so	so	SCONJ
admet-42	10	21	that	that	SCONJ
admet-42	10	22	even	even	ADV
admet-42	10	23	malabsorptive	malabsorptive	ADJ
admet-42	10	24	hydrophilic	hydrophilic	ADJ
admet-42	10	25	and	and	CCONJ
admet-42	10	26	high	high	ADJ
admet-42	10	27	weight	weight	NOUN
admet-42	10	28	molecular	molecular	ADJ
admet-42	10	29	compounds	compound	NOUN
admet-42	10	30	can	can	AUX
admet-42	10	31	diffuse	diffuse	VERB
admet-42	10	32	into	into	ADP
admet-42	10	33	the	the	DET
admet-42	10	34	deeper	deep	ADJ
admet-42	10	35	regions	region	NOUN
admet-42	10	36	of	of	ADP
admet-42	10	37	the	the	DET
admet-42	10	38	skin	skin	NOUN
admet-42	10	39	.	.	PUNCT
admet-42	11	1	an	an	DET
admet-42	11	2	assessment	assessment	NOUN
admet-42	11	3	of	of	ADP
admet-42	11	4	the	the	DET
admet-42	11	5	chemical	chemical	ADJ
admet-42	11	6	concentrations	concentration	NOUN
admet-42	11	7	of	of	ADP
admet-42	11	8	drugs	drug	NOUN
admet-42	11	9	in	in	ADP
admet-42	11	10	the	the	DET
admet-42	11	11	skin	skin	NOUN
admet-42	11	12	is	be	AUX
admet-42	11	13	essential	essential	ADJ
admet-42	11	14	for	for	ADP
admet-42	11	15	developing	develop	VERB
admet-42	11	16	topical	topical	ADJ
admet-42	11	17	pharmaceutical	pharmaceutical	ADJ
admet-42	11	18	products	product	NOUN
admet-42	11	19	and	and	CCONJ
admet-42	11	20	functional	functional	ADJ
admet-42	11	21	cosmetics	cosmetic	NOUN
admet-42	11	22	;	;	PUNCT
admet-42	11	23	therefore	therefore	ADV
admet-42	11	24	,	,	PUNCT
admet-42	11	25	drug	drug	NOUN
admet-42	11	26	disposition	disposition	NOUN
admet-42	11	27	in	in	ADP
admet-42	11	28	the	the	DET
admet-42	11	29	skin	skin	NOUN
admet-42	11	30	(	(	PUNCT
admet-42	11	31	stratum	stratum	PROPN
admet-42	11	32	corneum	corneum	NOUN
admet-42	11	33	,	,	PUNCT
admet-42	11	34	viable	viable	ADJ
admet-42	11	35	epidermis	epidermis	NOUN
admet-42	11	36	/	/	SYM
admet-42	11	37	dermis	dermis	NOUN
admet-42	11	38	,	,	PUNCT
admet-42	11	39	and	and	CCONJ
admet-42	11	40	appendages	appendage	NOUN
admet-42	11	41	)	)	PUNCT
admet-42	11	42	as	as	ADV
admet-42	11	43	well	well	ADV
admet-42	11	44	as	as	ADP
admet-42	11	45	the	the	DET
admet-42	11	46	concentration	concentration	NOUN
admet-42	11	47	-	-	PUNCT
admet-42	11	48	distance	distance	NOUN
admet-42	11	49	profiles	profile	NOUN
admet-42	11	50	of	of	ADP
admet-42	11	51	these	these	DET
admet-42	11	52	compounds	compound	NOUN
admet-42	11	53	through	through	ADP
admet-42	11	54	the	the	DET
admet-42	11	55	skin	skin	NOUN
admet-42	11	56	need	need	VERB
admet-42	11	57	to	to	PART
admet-42	11	58	be	be	AUX
admet-42	11	59	elucidated	elucidate	VERB
admet-42	11	60	in	in	ADP
admet-42	11	61	more	more	ADJ
admet-42	11	62	detail	detail	NOUN
admet-42	11	63	[	[	X
admet-42	11	64	1	1	NUM
admet-42	11	65	-	-	SYM
admet-42	11	66	4	4	NUM
admet-42	11	67	]	]	PUNCT
admet-42	11	68	.	.	PUNCT
admet-42	12	1	since	since	SCONJ
admet-42	12	2	the	the	DET
admet-42	12	3	skin	skin	NOUN
admet-42	12	4	,	,	PUNCT
admet-42	12	5	which	which	PRON
admet-42	12	6	is	be	AUX
admet-42	12	7	a	a	DET
admet-42	12	8	structurally	structurally	ADV
admet-42	12	9	heterogeneous	heterogeneous	ADJ
admet-42	12	10	organ	organ	NOUN
admet-42	12	11	,	,	PUNCT
admet-42	12	12	is	be	AUX
admet-42	12	13	not	not	PART
admet-42	12	14	uniformly	uniformly	ADV
admet-42	12	15	distributed	distribute	VERB
admet-42	12	16	for	for	ADP
admet-42	12	17	topically	topically	ADV
admet-42	12	18	applied	apply	VERB
admet-42	12	19	drugs	drug	NOUN
admet-42	12	20	,	,	PUNCT
admet-42	12	21	it	it	PRON
admet-42	12	22	remains	remain	VERB
admet-42	12	23	unclear	unclear	ADJ
admet-42	12	24	how	how	SCONJ
admet-42	12	25	drugs	drug	NOUN
admet-42	12	26	permeate	permeate	VERB
admet-42	12	27	the	the	DET
admet-42	12	28	skin	skin	NOUN
admet-42	12	29	layers	layer	NOUN
admet-42	12	30	from	from	ADP
admet-42	12	31	the	the	DET
admet-42	12	32	surface	surface	NOUN
admet-42	12	33	to	to	ADP
admet-42	12	34	deeper	deep	ADJ
admet-42	12	35	regions	region	NOUN
admet-42	12	36	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-42	12	37	mailto:sugib@josai.ac.jp	mailto:sugib@josai.ac.jp	PROPN
admet-42	12	38	mailto:sugib@josai.ac.jp	mailto:sugib@josai.ac.jp	PROPN
admet-42	12	39	sugibayashi	sugibayashi	PROPN
admet-42	12	40	et.al	et.al	PROPN
admet-42	12	41	.	.	PUNCT
admet-42	13	1	admet	admet	PROPN
admet-42	13	2	&	&	CCONJ
admet-42	13	3	dmpk	dmpk	PROPN
admet-42	13	4	2(4	2(4	NUM
admet-42	13	5	)	)	PUNCT
admet-42	13	6	(	(	PUNCT
admet-42	13	7	2014	2014	NUM
admet-42	13	8	)	)	PUNCT
admet-42	13	9	221	221	NUM
admet-42	13	10	-	-	SYM
admet-42	13	11	234	234	NUM
admet-42	13	12	222	222	NUM
admet-42	13	13	over	over	ADP
admet-42	13	14	time	time	NOUN
admet-42	13	15	.	.	PUNCT
admet-42	14	1	the	the	DET
admet-42	14	2	skin	skin	NOUN
admet-42	14	3	is	be	AUX
admet-42	14	4	an	an	DET
admet-42	14	5	extremely	extremely	ADV
admet-42	14	6	thin	thin	ADJ
admet-42	14	7	organ	organ	NOUN
admet-42	14	8	;	;	PUNCT
admet-42	14	9	thus	thus	ADV
admet-42	14	10	,	,	PUNCT
admet-42	14	11	as	as	ADP
admet-42	14	12	a	a	DET
admet-42	14	13	small	small	ADJ
admet-42	14	14	amount	amount	NOUN
admet-42	14	15	of	of	ADP
admet-42	14	16	a	a	DET
admet-42	14	17	drug	drug	NOUN
admet-42	14	18	may	may	AUX
admet-42	14	19	result	result	VERB
admet-42	14	20	in	in	ADP
admet-42	14	21	a	a	DET
admet-42	14	22	high	high	ADJ
admet-42	14	23	target	target	NOUN
admet-42	14	24	concentration	concentration	NOUN
admet-42	14	25	,	,	PUNCT
admet-42	14	26	a	a	DET
admet-42	14	27	sensitive	sensitive	ADJ
admet-42	14	28	method	method	NOUN
admet-42	14	29	is	be	AUX
admet-42	14	30	needed	need	VERB
admet-42	14	31	to	to	PART
admet-42	14	32	determine	determine	VERB
admet-42	14	33	the	the	DET
admet-42	14	34	drug	drug	NOUN
admet-42	14	35	concentration	concentration	NOUN
admet-42	14	36	in	in	ADP
admet-42	14	37	each	each	DET
admet-42	14	38	layer	layer	NOUN
admet-42	14	39	of	of	ADP
admet-42	14	40	the	the	DET
admet-42	14	41	skin	skin	NOUN
admet-42	14	42	after	after	ADP
admet-42	14	43	its	its	PRON
admet-42	14	44	topical	topical	ADJ
admet-42	14	45	application	application	NOUN
admet-42	14	46	.	.	PUNCT
admet-42	15	1	several	several	ADJ
admet-42	15	2	conventional	conventional	ADJ
admet-42	15	3	methods	method	NOUN
admet-42	15	4	,	,	PUNCT
admet-42	15	5	including	include	VERB
admet-42	15	6	the	the	DET
admet-42	15	7	suction	suction	NOUN
admet-42	15	8	blister	blister	NOUN
admet-42	15	9	[	[	X
admet-42	15	10	5	5	NUM
admet-42	15	11	]	]	PUNCT
admet-42	15	12	,	,	PUNCT
admet-42	15	13	punch	punch	VERB
admet-42	15	14	and	and	CCONJ
admet-42	15	15	shave	shave	NOUN
admet-42	15	16	biopsy	biopsy	NOUN
admet-42	16	1	[	[	X
admet-42	16	2	6	6	NUM
admet-42	16	3	]	]	PUNCT
admet-42	16	4	,	,	PUNCT
admet-42	16	5	and	and	CCONJ
admet-42	16	6	homogenization	homogenization	NOUN
admet-42	16	7	[	[	X
admet-42	16	8	7	7	NUM
admet-42	16	9	]	]	ADJ
admet-42	16	10	methods	method	NOUN
admet-42	16	11	,	,	PUNCT
admet-42	16	12	have	have	AUX
admet-42	16	13	been	be	AUX
admet-42	16	14	used	use	VERB
admet-42	16	15	to	to	PART
admet-42	16	16	measure	measure	VERB
admet-42	16	17	the	the	DET
admet-42	16	18	concentration	concentration	NOUN
admet-42	16	19	of	of	ADP
admet-42	16	20	a	a	DET
admet-42	16	21	drug	drug	NOUN
admet-42	16	22	in	in	ADP
admet-42	16	23	the	the	DET
admet-42	16	24	skin	skin	NOUN
admet-42	16	25	.	.	PUNCT
admet-42	17	1	however	however	ADV
admet-42	17	2	,	,	PUNCT
admet-42	17	3	these	these	DET
admet-42	17	4	methods	method	NOUN
admet-42	17	5	can	can	AUX
admet-42	17	6	only	only	ADV
admet-42	17	7	measure	measure	VERB
admet-42	17	8	average	average	ADJ
admet-42	17	9	drug	drug	NOUN
admet-42	17	10	concentrations	concentration	NOUN
admet-42	17	11	in	in	ADP
admet-42	17	12	the	the	DET
admet-42	17	13	total	total	ADJ
admet-42	17	14	area	area	NOUN
admet-42	17	15	of	of	ADP
admet-42	17	16	excised	excised	ADJ
admet-42	17	17	whole	whole	ADJ
admet-42	17	18	skin	skin	NOUN
admet-42	17	19	instead	instead	ADV
admet-42	17	20	of	of	ADP
admet-42	17	21	those	those	PRON
admet-42	17	22	at	at	ADP
admet-42	17	23	each	each	DET
admet-42	17	24	depth	depth	NOUN
admet-42	17	25	of	of	ADP
admet-42	17	26	the	the	DET
admet-42	17	27	skin	skin	NOUN
admet-42	17	28	.	.	PUNCT
admet-42	18	1	furthermore	furthermore	ADV
admet-42	18	2	,	,	PUNCT
admet-42	18	3	these	these	DET
admet-42	18	4	methods	method	NOUN
admet-42	18	5	can	can	AUX
admet-42	18	6	not	not	PART
admet-42	18	7	provide	provide	VERB
admet-42	18	8	a	a	DET
admet-42	18	9	visual	visual	ADJ
admet-42	18	10	observation	observation	NOUN
admet-42	18	11	of	of	ADP
admet-42	18	12	drug	drug	NOUN
admet-42	18	13	disposition	disposition	NOUN
admet-42	18	14	from	from	ADP
admet-42	18	15	the	the	DET
admet-42	18	16	surface	surface	NOUN
admet-42	18	17	to	to	ADP
admet-42	18	18	deeper	deep	ADJ
admet-42	18	19	regions	region	NOUN
admet-42	18	20	of	of	ADP
admet-42	18	21	the	the	DET
admet-42	18	22	skin	skin	NOUN
admet-42	18	23	,	,	PUNCT
admet-42	18	24	which	which	PRON
admet-42	18	25	is	be	AUX
admet-42	18	26	necessary	necessary	ADJ
admet-42	18	27	for	for	ADP
admet-42	18	28	further	further	ADJ
admet-42	18	29	understanding	understanding	NOUN
admet-42	18	30	of	of	ADP
admet-42	18	31	the	the	DET
admet-42	18	32	dermatopharmacokinetics	dermatopharmacokinetic	NOUN
admet-42	18	33	of	of	ADP
admet-42	18	34	topically	topically	ADV
admet-42	18	35	applied	apply	VERB
admet-42	18	36	drugs	drug	NOUN
admet-42	18	37	.	.	PUNCT
admet-42	19	1	the	the	DET
admet-42	19	2	tape	tape	NOUN
admet-42	19	3	-	-	PUNCT
admet-42	19	4	stripping	strip	VERB
admet-42	19	5	method	method	NOUN
admet-42	19	6	[	[	X
admet-42	19	7	8	8	NUM
admet-42	19	8	-	-	SYM
admet-42	19	9	12	12	NUM
admet-42	19	10	]	]	PUNCT
admet-42	19	11	has	have	AUX
admet-42	19	12	been	be	AUX
admet-42	19	13	used	use	VERB
admet-42	19	14	to	to	PART
admet-42	19	15	measure	measure	VERB
admet-42	19	16	drug	drug	NOUN
admet-42	19	17	concentrations	concentration	NOUN
admet-42	19	18	at	at	ADP
admet-42	19	19	each	each	DET
admet-42	19	20	depth	depth	NOUN
admet-42	19	21	of	of	ADP
admet-42	19	22	the	the	DET
admet-42	19	23	skin	skin	NOUN
admet-42	19	24	,	,	PUNCT
admet-42	19	25	but	but	CCONJ
admet-42	19	26	only	only	ADV
admet-42	19	27	in	in	ADP
admet-42	19	28	the	the	DET
admet-42	19	29	stratum	stratum	NOUN
admet-42	19	30	corneum	corneum	NOUN
admet-42	19	31	.	.	PUNCT
admet-42	20	1	a	a	DET
admet-42	20	2	clearer	clear	ADJ
admet-42	20	3	understanding	understanding	NOUN
admet-42	20	4	of	of	ADP
admet-42	20	5	drug	drug	NOUN
admet-42	20	6	disposition	disposition	NOUN
admet-42	20	7	through	through	ADP
admet-42	20	8	the	the	DET
admet-42	20	9	whole	whole	ADJ
admet-42	20	10	skin	skin	NOUN
admet-42	20	11	will	will	AUX
admet-42	20	12	be	be	AUX
admet-42	20	13	helpful	helpful	ADJ
admet-42	20	14	for	for	ADP
admet-42	20	15	evaluating	evaluate	VERB
admet-42	20	16	their	their	PRON
admet-42	20	17	safety	safety	NOUN
admet-42	20	18	and	and	CCONJ
admet-42	20	19	efficacy	efficacy	NOUN
admet-42	20	20	by	by	ADP
admet-42	20	21	specifying	specify	VERB
admet-42	20	22	the	the	DET
admet-42	20	23	skin	skin	NOUN
admet-42	20	24	tissue	tissue	NOUN
admet-42	20	25	targeted	target	VERB
admet-42	20	26	by	by	ADP
admet-42	20	27	these	these	DET
admet-42	20	28	drugs	drug	NOUN
admet-42	20	29	.	.	PUNCT
admet-42	21	1	however	however	ADV
admet-42	21	2	,	,	PUNCT
admet-42	21	3	the	the	DET
admet-42	21	4	drug	drug	NOUN
admet-42	21	5	concentration	concentration	NOUN
admet-42	21	6	at	at	ADP
admet-42	21	7	each	each	DET
admet-42	21	8	depth	depth	NOUN
admet-42	21	9	of	of	ADP
admet-42	21	10	the	the	DET
admet-42	21	11	skin	skin	NOUN
admet-42	21	12	has	have	AUX
admet-42	21	13	been	be	AUX
admet-42	21	14	predicted	predict	VERB
admet-42	21	15	using	use	VERB
admet-42	21	16	various	various	ADJ
admet-42	21	17	mathematical	mathematical	ADJ
admet-42	21	18	equations	equation	NOUN
admet-42	22	1	[	[	X
admet-42	22	2	13	13	NUM
admet-42	22	3	-	-	SYM
admet-42	22	4	18	18	NUM
admet-42	22	5	]	]	PUNCT
admet-42	22	6	.	.	PUNCT
admet-42	23	1	we	we	PRON
admet-42	23	2	previously	previously	ADV
admet-42	23	3	reported	report	VERB
admet-42	23	4	that	that	SCONJ
admet-42	23	5	the	the	DET
admet-42	23	6	cutaneous	cutaneous	ADJ
admet-42	23	7	disposition	disposition	NOUN
admet-42	23	8	of	of	ADP
admet-42	23	9	topically	topically	ADV
admet-42	23	10	applied	apply	VERB
admet-42	23	11	drugs	drug	NOUN
admet-42	23	12	could	could	AUX
admet-42	23	13	be	be	AUX
admet-42	23	14	predicted	predict	VERB
admet-42	23	15	using	use	VERB
admet-42	23	16	the	the	DET
admet-42	23	17	difference	difference	NOUN
admet-42	23	18	method	method	NOUN
admet-42	23	19	based	base	VERB
admet-42	23	20	on	on	ADP
admet-42	23	21	fick	fick	PROPN
admet-42	23	22	’s	’s	PART
admet-42	23	23	2nd	2nd	ADJ
admet-42	23	24	law	law	NOUN
admet-42	23	25	of	of	ADP
admet-42	23	26	diffusion	diffusion	NOUN
admet-42	23	27	,	,	PUNCT
admet-42	23	28	and	and	CCONJ
admet-42	23	29	also	also	ADV
admet-42	23	30	that	that	SCONJ
admet-42	23	31	the	the	DET
admet-42	23	32	average	average	ADJ
admet-42	23	33	drug	drug	NOUN
admet-42	23	34	concentration	concentration	NOUN
admet-42	23	35	in	in	ADP
admet-42	23	36	the	the	DET
admet-42	23	37	stratum	stratum	NOUN
admet-42	23	38	corneum	corneum	NOUN
admet-42	23	39	and	and	CCONJ
admet-42	23	40	viable	viable	ADJ
admet-42	23	41	epidermis	epidermis	NOUN
admet-42	23	42	/	/	SYM
admet-42	23	43	dermis	dermis	NOUN
admet-42	23	44	could	could	AUX
admet-42	23	45	be	be	AUX
admet-42	23	46	determined	determine	VERB
admet-42	23	47	separately	separately	ADV
admet-42	23	48	[	[	X
admet-42	23	49	19	19	NUM
admet-42	23	50	-	-	SYM
admet-42	23	51	22	22	NUM
admet-42	23	52	]	]	PUNCT
admet-42	23	53	.	.	PUNCT
admet-42	24	1	however	however	ADV
admet-42	24	2	,	,	PUNCT
admet-42	24	3	fick	fick	PROPN
admet-42	24	4	’s	’s	PART
admet-42	24	5	law	law	NOUN
admet-42	24	6	-	-	PUNCT
admet-42	24	7	based	base	VERB
admet-42	24	8	approach	approach	NOUN
admet-42	24	9	requires	require	VERB
admet-42	24	10	a	a	DET
admet-42	24	11	relatively	relatively	ADV
admet-42	24	12	advanced	advanced	ADJ
admet-42	24	13	knowledge	knowledge	NOUN
admet-42	24	14	of	of	ADP
admet-42	24	15	mathematical	mathematical	ADJ
admet-42	24	16	equations	equation	NOUN
admet-42	24	17	in	in	ADP
admet-42	24	18	order	order	NOUN
admet-42	24	19	to	to	PART
admet-42	24	20	estimate	estimate	VERB
admet-42	24	21	the	the	DET
admet-42	24	22	cutaneous	cutaneous	ADJ
admet-42	24	23	disposition	disposition	NOUN
admet-42	24	24	of	of	ADP
admet-42	24	25	topically	topically	ADV
admet-42	24	26	applied	apply	VERB
admet-42	24	27	drugs	drug	NOUN
admet-42	24	28	.	.	PUNCT
admet-42	25	1	figure	figure	NOUN
admet-42	25	2	1	1	NUM
admet-42	25	3	.	.	PUNCT
admet-42	26	1	chemical	chemical	ADJ
admet-42	26	2	structure	structure	NOUN
admet-42	26	3	of	of	ADP
admet-42	26	4	fd-4	fd-4	NOUN
admet-42	26	5	therefore	therefore	ADV
admet-42	26	6	,	,	PUNCT
admet-42	26	7	the	the	DET
admet-42	26	8	aim	aim	NOUN
admet-42	26	9	of	of	ADP
admet-42	26	10	the	the	DET
admet-42	26	11	present	present	ADJ
admet-42	26	12	study	study	NOUN
admet-42	26	13	was	be	AUX
admet-42	26	14	to	to	PART
admet-42	26	15	develop	develop	VERB
admet-42	26	16	a	a	DET
admet-42	26	17	quantitative	quantitative	ADJ
admet-42	26	18	,	,	PUNCT
admet-42	26	19	visual	visual	ADJ
admet-42	26	20	,	,	PUNCT
admet-42	26	21	simple	simple	ADJ
admet-42	26	22	,	,	PUNCT
admet-42	26	23	sensitive	sensitive	ADJ
admet-42	26	24	,	,	PUNCT
admet-42	26	25	and	and	CCONJ
admet-42	26	26	effective	effective	ADJ
admet-42	26	27	method	method	NOUN
admet-42	26	28	to	to	ADP
admet-42	26	29	analysis	analysis	NOUN
admet-42	26	30	concentration	concentration	NOUN
admet-42	26	31	-	-	PUNCT
admet-42	26	32	distance	distance	NOUN
admet-42	26	33	profile	profile	NOUN
admet-42	26	34	of	of	ADP
admet-42	26	35	topically	topically	ADV
admet-42	26	36	applied	apply	VERB
admet-42	26	37	compounds	compound	NOUN
admet-42	26	38	using	use	VERB
admet-42	26	39	confocal	confocal	ADJ
admet-42	26	40	laser	laser	NOUN
admet-42	26	41	scanning	scan	VERB
admet-42	26	42	microscopy	microscopy	NOUN
admet-42	26	43	(	(	PUNCT
admet-42	26	44	clsm	clsm	NOUN
admet-42	26	45	)	)	PUNCT
admet-42	26	46	.	.	PUNCT
admet-42	27	1	the	the	DET
admet-42	27	2	clsm	clsm	NOUN
admet-42	27	3	could	could	AUX
admet-42	27	4	be	be	AUX
admet-42	27	5	used	use	VERB
admet-42	27	6	to	to	PART
admet-42	27	7	quantitatively	quantitatively	ADV
admet-42	27	8	visualize	visualize	VERB
admet-42	27	9	disposition	disposition	NOUN
admet-42	27	10	of	of	ADP
admet-42	27	11	fluorescent	fluorescent	ADJ
admet-42	27	12	compounds	compound	NOUN
admet-42	27	13	or	or	CCONJ
admet-42	27	14	high	high	ADJ
admet-42	27	15	molecular	molecular	ADJ
admet-42	27	16	weight	weight	NOUN
admet-42	27	17	compounds	compound	NOUN
admet-42	27	18	with	with	ADP
admet-42	27	19	fluorescent	fluorescent	ADJ
admet-42	27	20	labeling	labeling	NOUN
admet-42	27	21	moiety	moiety	NOUN
admet-42	27	22	through	through	ADP
admet-42	27	23	the	the	DET
admet-42	27	24	skin	skin	NOUN
admet-42	27	25	from	from	ADP
admet-42	27	26	the	the	DET
admet-42	27	27	viewpoint	viewpoint	NOUN
admet-42	27	28	of	of	ADP
admet-42	27	29	depth	depth	NOUN
admet-42	27	30	.	.	PUNCT
admet-42	28	1	in	in	ADP
admet-42	28	2	the	the	DET
admet-42	28	3	present	present	ADJ
admet-42	28	4	study	study	NOUN
admet-42	28	5	,	,	PUNCT
admet-42	28	6	the	the	DET
admet-42	28	7	mathematical	mathematical	ADJ
admet-42	28	8	approach	approach	NOUN
admet-42	28	9	represented	represent	VERB
admet-42	28	10	by	by	ADP
admet-42	28	11	the	the	DET
admet-42	28	12	difference	difference	NOUN
admet-42	28	13	equation	equation	NOUN
admet-42	28	14	method	method	NOUN
admet-42	28	15	based	base	VERB
admet-42	28	16	on	on	ADP
admet-42	28	17	fick	fick	PROPN
admet-42	28	18	’s	’s	PART
admet-42	28	19	law	law	NOUN
admet-42	28	20	of	of	ADP
admet-42	28	21	diffusion	diffusion	NOUN
admet-42	28	22	to	to	PART
admet-42	28	23	obtain	obtain	VERB
admet-42	28	24	a	a	DET
admet-42	28	25	concentration	concentration	NOUN
admet-42	28	26	-	-	PUNCT
admet-42	28	27	distance	distance	NOUN
admet-42	28	28	profile	profile	NOUN
admet-42	28	29	was	be	AUX
admet-42	28	30	also	also	ADV
admet-42	28	31	used	use	VERB
admet-42	28	32	for	for	ADP
admet-42	28	33	comparisons	comparison	NOUN
admet-42	28	34	to	to	ADP
admet-42	28	35	the	the	DET
admet-42	28	36	clsm	clsm	NOUN
admet-42	28	37	technique	technique	NOUN
admet-42	28	38	.	.	PUNCT
admet-42	29	1	we	we	PRON
admet-42	29	2	applied	apply	VERB
admet-42	29	3	fitc	fitc	NOUN
admet-42	29	4	-	-	PUNCT
admet-42	29	5	dextran	dextran	NOUN
admet-42	29	6	(	(	PUNCT
admet-42	29	7	fig	fig	NOUN
admet-42	29	8	.	.	NOUN
admet-42	30	1	1	1	X
admet-42	30	2	)	)	PUNCT
admet-42	30	3	having	have	VERB
admet-42	30	4	a	a	DET
admet-42	30	5	molecular	molecular	ADJ
admet-42	30	6	o	o	NOUN
admet-42	31	1	h	h	NOUN
admet-42	32	1	oh	oh	INTJ
admet-42	32	2	h	h	NOUN
admet-42	33	1	o	o	NOUN
admet-42	33	2	h	h	NOUN
admet-42	34	1	ohh	ohh	INTJ
admet-42	35	1	oh	oh	INTJ
admet-42	35	2	ch2	ch2	PROPN
admet-42	35	3	h	h	NOUN
admet-42	36	1	o	o	NOUN
admet-42	36	2	h	h	NOUN
admet-42	37	1	o	o	NOUN
admet-42	37	2	h	h	NOUN
admet-42	38	1	o	o	NOUN
admet-42	38	2	h	h	NOUN
admet-42	39	1	ohh	ohh	INTJ
admet-42	40	1	oh	oh	INTJ
admet-42	40	2	h	h	NOUN
admet-42	41	1	ch2	ch2	PROPN
admet-42	41	2	cs	cs	PROPN
admet-42	41	3	nh	nh	PROPN
admet-42	41	4	oho	oho	INTJ
admet-42	42	1	oh	oh	INTJ
admet-42	42	2	o	o	INTJ
admet-42	43	1	c	c	NOUN
admet-42	44	1	o	o	NOUN
admet-42	44	2	o	o	NOUN
admet-42	45	1	h	h	NOUN
admet-42	46	1	o	o	NOUN
admet-42	46	2	h	h	NOUN
admet-42	47	1	o	o	NOUN
admet-42	47	2	h	h	NOUN
admet-42	48	1	ohh	ohh	INTJ
admet-42	49	1	oh	oh	INTJ
admet-42	49	2	ch2	ch2	PROPN
admet-42	49	3	h	h	NOUN
admet-42	50	1	o	o	NOUN
admet-42	50	2	h	h	NOUN
admet-42	51	1	oh	oh	INTJ
admet-42	51	2	h	h	NOUN
admet-42	52	1	o	o	NOUN
admet-42	52	2	h	h	NOUN
admet-42	53	1	ohh	ohh	INTJ
admet-42	54	1	oh	oh	INTJ
admet-42	54	2	h	h	NOUN
admet-42	55	1	ch2	ch2	PROPN
admet-42	55	2	cs	cs	PROPN
admet-42	55	3	nh	nh	PROPN
admet-42	55	4	o	o	NOUN
admet-42	56	1	h	h	NOUN
admet-42	57	1	oh	oh	INTJ
admet-42	57	2	h	h	NOUN
admet-42	58	1	o	o	NOUN
admet-42	58	2	h	h	NOUN
admet-42	59	1	ohh	ohh	INTJ
admet-42	60	1	oh	oh	INTJ
admet-42	60	2	ch2	ch2	PROPN
admet-42	60	3	h	h	NOUN
admet-42	61	1	o	o	NOUN
admet-42	61	2	h	h	NOUN
admet-42	62	1	oh	oh	INTJ
admet-42	62	2	h	h	NOUN
admet-42	63	1	o	o	NOUN
admet-42	63	2	h	h	NOUN
admet-42	64	1	ohh	ohh	INTJ
admet-42	64	2	h	h	NOUN
admet-42	65	1	ch2	ch2	PROPN
admet-42	65	2	o	o	PROPN
admet-42	65	3	h	h	NOUN
admet-42	66	1	oh	oh	INTJ
admet-42	66	2	h	h	NOUN
admet-42	67	1	o	o	NOUN
admet-42	67	2	h	h	NOUN
admet-42	68	1	ohh	ohh	INTJ
admet-42	69	1	oh	oh	INTJ
admet-42	69	2	ch2	ch2	PROPN
admet-42	69	3	h	h	NOUN
admet-42	70	1	o	o	NOUN
admet-42	70	2	h	h	NOUN
admet-42	71	1	oh	oh	INTJ
admet-42	71	2	h	h	NOUN
admet-42	72	1	o	o	NOUN
admet-42	72	2	h	h	NOUN
admet-42	73	1	ohh	ohh	INTJ
admet-42	74	1	oh	oh	INTJ
admet-42	74	2	h	h	NOUN
admet-42	74	3	ch2	ch2	PROPN
admet-42	74	4	n	n	PROPN
admet-42	74	5	admet	admet	PROPN
admet-42	74	6	&	&	CCONJ
admet-42	74	7	dmpk	dmpk	PROPN
admet-42	74	8	2(4	2(4	NUM
admet-42	74	9	)	)	PUNCT
admet-42	74	10	(	(	PUNCT
admet-42	74	11	2014	2014	NUM
admet-42	74	12	)	)	PUNCT
admet-42	74	13	221	221	NUM
admet-42	74	14	-	-	SYM
admet-42	74	15	234	234	NUM
admet-42	74	16	imaging	imaging	NOUN
admet-42	74	17	analysis	analysis	NOUN
admet-42	74	18	of	of	ADP
admet-42	74	19	topically	topically	ADV
admet-42	74	20	applied	apply	VERB
admet-42	74	21	fitc	fitc	NOUN
admet-42	74	22	-	-	PUNCT
admet-42	74	23	dextran	dextran	VERB
admet-42	74	24	doi	doi	NOUN
admet-42	74	25	:	:	PUNCT
admet-42	74	26	10.5599	10.5599	NUM
admet-42	74	27	/	/	SYM
admet-42	74	28	admet.2.4.42	admet.2.4.42	PROPN
admet-42	74	29	223	223	NUM
admet-42	74	30	weight	weight	NOUN
admet-42	74	31	of	of	ADP
admet-42	74	32	about	about	ADV
admet-42	74	33	4	4	NUM
admet-42	74	34	kda	kda	NOUN
admet-42	74	35	(	(	PUNCT
admet-42	74	36	fd-4	fd-4	NOUN
admet-42	74	37	)	)	PUNCT
admet-42	74	38	as	as	ADP
admet-42	74	39	a	a	DET
admet-42	74	40	candidate	candidate	NOUN
admet-42	74	41	to	to	PART
admet-42	74	42	excised	excise	VERB
admet-42	74	43	skin	skin	NOUN
admet-42	74	44	from	from	ADP
admet-42	74	45	the	the	DET
admet-42	74	46	pig	pig	NOUN
admet-42	74	47	ear	ear	NOUN
admet-42	74	48	in	in	ADP
admet-42	74	49	which	which	PRON
admet-42	74	50	the	the	DET
admet-42	74	51	stratum	stratum	NOUN
admet-42	74	52	corneum	corneum	NOUN
admet-42	74	53	had	have	AUX
admet-42	74	54	been	be	AUX
admet-42	74	55	removed	remove	VERB
admet-42	74	56	by	by	ADP
admet-42	74	57	stripping	strip	VERB
admet-42	74	58	.	.	PUNCT
admet-42	75	1	dermatodynamics	dermatodynamic	NOUN
admet-42	75	2	could	could	AUX
admet-42	75	3	be	be	AUX
admet-42	75	4	closely	closely	ADV
admet-42	75	5	related	relate	VERB
admet-42	75	6	to	to	ADP
admet-42	75	7	drug	drug	NOUN
admet-42	75	8	concentration	concentration	NOUN
admet-42	75	9	in	in	ADP
admet-42	75	10	viable	viable	ADJ
admet-42	75	11	epidermis	epidermis	NOUN
admet-42	75	12	and	and	CCONJ
admet-42	75	13	dermis	dermis	NOUN
admet-42	75	14	not	not	PART
admet-42	75	15	in	in	ADP
admet-42	75	16	the	the	DET
admet-42	75	17	stratum	stratum	NOUN
admet-42	75	18	corneum	corneum	VERB
admet-42	75	19	after	after	ADP
admet-42	75	20	topical	topical	ADJ
admet-42	75	21	application	application	NOUN
admet-42	75	22	.	.	PUNCT
admet-42	76	1	thus	thus	ADV
admet-42	76	2	,	,	PUNCT
admet-42	76	3	we	we	PRON
admet-42	76	4	selected	select	VERB
admet-42	76	5	the	the	DET
admet-42	76	6	stripped	strip	VERB
admet-42	76	7	skin	skin	NOUN
admet-42	76	8	to	to	PART
admet-42	76	9	investigate	investigate	VERB
admet-42	76	10	the	the	DET
admet-42	76	11	possibility	possibility	NOUN
admet-42	76	12	of	of	ADP
admet-42	76	13	quantitative	quantitative	ADJ
admet-42	76	14	determination	determination	NOUN
admet-42	76	15	of	of	ADP
admet-42	76	16	fd-4	fd-4	NOUN
admet-42	76	17	concentration	concentration	NOUN
admet-42	76	18	in	in	ADP
admet-42	76	19	viable	viable	ADJ
admet-42	76	20	epidermis	epidermis	NOUN
admet-42	76	21	and	and	CCONJ
admet-42	76	22	dermis	dermis	NOUN
admet-42	76	23	.	.	PUNCT
admet-42	77	1	concentration	concentration	NOUN
admet-42	77	2	-	-	PUNCT
admet-42	77	3	distance	distance	NOUN
admet-42	77	4	profile	profile	NOUN
admet-42	77	5	of	of	ADP
admet-42	77	6	fd-4	fd-4	NOUN
admet-42	77	7	through	through	ADP
admet-42	77	8	the	the	DET
admet-42	77	9	skin	skin	NOUN
admet-42	77	10	was	be	AUX
admet-42	77	11	quantified	quantify	VERB
admet-42	77	12	by	by	ADP
admet-42	77	13	imaging	image	VERB
admet-42	77	14	analysis	analysis	NOUN
admet-42	77	15	(	(	PUNCT
admet-42	77	16	clsm	clsm	NOUN
admet-42	77	17	)	)	PUNCT
admet-42	77	18	over	over	ADP
admet-42	77	19	time	time	NOUN
admet-42	77	20	.	.	PUNCT
admet-42	78	1	theoretical	theoretical	ADJ
admet-42	78	2	[	[	X
admet-42	78	3	22	22	NUM
admet-42	78	4	-	-	SYM
admet-42	78	5	25	25	NUM
admet-42	78	6	]	]	PUNCT
admet-42	78	7	stripped	strip	VERB
admet-42	78	8	skin	skin	NOUN
admet-42	78	9	excised	excise	VERB
admet-42	78	10	from	from	ADP
admet-42	78	11	the	the	DET
admet-42	78	12	pig	pig	NOUN
admet-42	78	13	ear	ear	NOUN
admet-42	78	14	was	be	AUX
admet-42	78	15	assumed	assume	VERB
admet-42	78	16	to	to	PART
admet-42	78	17	be	be	AUX
admet-42	78	18	a	a	DET
admet-42	78	19	homogeneous	homogeneous	ADJ
admet-42	78	20	membrane	membrane	NOUN
admet-42	79	1	[	[	X
admet-42	79	2	26	26	NUM
admet-42	79	3	]	]	PUNCT
admet-42	79	4	.	.	PUNCT
admet-42	80	1	the	the	DET
admet-42	80	2	present	present	ADJ
admet-42	80	3	chemical	chemical	PROPN
admet-42	80	4	compound	compound	PROPN
admet-42	80	5	permeation	permeation	NOUN
admet-42	80	6	study	study	NOUN
admet-42	80	7	through	through	ADP
admet-42	80	8	the	the	DET
admet-42	80	9	skin	skin	NOUN
admet-42	80	10	was	be	AUX
admet-42	80	11	performed	perform	VERB
admet-42	80	12	at	at	ADP
admet-42	80	13	an	an	DET
admet-42	80	14	infinite	infinite	NOUN
admet-42	80	15	dose	dose	NOUN
admet-42	80	16	under	under	ADP
admet-42	80	17	a	a	DET
admet-42	80	18	sink	sink	NOUN
admet-42	80	19	condition	condition	NOUN
admet-42	80	20	in	in	ADP
admet-42	80	21	the	the	DET
admet-42	80	22	receiver	receiver	ADJ
admet-42	80	23	compartment	compartment	NOUN
admet-42	80	24	.	.	PUNCT
admet-42	81	1	figure	figure	NOUN
admet-42	81	2	2	2	NUM
admet-42	81	3	illustrates	illustrate	VERB
admet-42	81	4	the	the	DET
admet-42	81	5	typical	typical	ADJ
admet-42	81	6	concentration	concentration	NOUN
admet-42	81	7	-	-	PUNCT
admet-42	81	8	distance	distance	NOUN
admet-42	81	9	profile	profile	NOUN
admet-42	81	10	of	of	ADP
admet-42	81	11	a	a	DET
admet-42	81	12	chemical	chemical	NOUN
admet-42	81	13	compound	compound	NOUN
admet-42	81	14	across	across	ADP
admet-42	81	15	stripped	strip	VERB
admet-42	81	16	skin	skin	NOUN
admet-42	81	17	in	in	ADP
admet-42	81	18	the	the	DET
admet-42	81	19	present	present	ADJ
admet-42	81	20	study	study	NOUN
admet-42	81	21	.	.	PUNCT
admet-42	82	1	membrane	membrane	NOUN
admet-42	82	2	d	d	NOUN
admet-42	82	3	c	c	NOUN
admet-42	82	4	・	・	PUNCT
admet-42	82	5	c	c	PROPN
admet-42	83	1	k	k	PROPN
admet-42	83	2	d	d	NOUN
admet-42	83	3	x	x	PUNCT
admet-42	83	4	=	=	PUNCT
admet-42	83	5	l	l	NOUN
admet-42	83	6	x	x	PUNCT
admet-42	83	7	=	=	SYM
admet-42	83	8	0	0	PUNCT
admet-42	83	9	c	c	NOUN
admet-42	83	10	donor	donor	NOUN
admet-42	83	11	receiver	receiver	NOUN
admet-42	83	12	t1	t1	VERB
admet-42	83	13	steady	steady	ADJ
admet-42	83	14	state	state	NOUN
admet-42	83	15	t2	t2	PROPN
admet-42	83	16	t3	t3	PROPN
admet-42	83	17	t5	t5	PROPN
admet-42	83	18	figure	figure	NOUN
admet-42	83	19	2	2	NUM
admet-42	83	20	.	.	PUNCT
admet-42	83	21	schematic	schematic	ADJ
admet-42	83	22	diagram	diagram	NOUN
admet-42	83	23	of	of	ADP
admet-42	83	24	a	a	DET
admet-42	83	25	concentration	concentration	NOUN
admet-42	83	26	-	-	PUNCT
admet-42	83	27	distance	distance	NOUN
admet-42	83	28	profile	profile	NOUN
admet-42	83	29	in	in	ADP
admet-42	83	30	stripped	strip	VERB
admet-42	83	31	pig	pig	NOUN
admet-42	83	32	ear	ear	NOUN
admet-42	83	33	skin	skin	NOUN
admet-42	83	34	(	(	PUNCT
admet-42	83	35	one	one	NUM
admet-42	83	36	-	-	PUNCT
admet-42	83	37	layered	layer	VERB
admet-42	83	38	diffusion	diffusion	NOUN
admet-42	83	39	model	model	NOUN
admet-42	83	40	)	)	PUNCT
admet-42	83	41	the	the	DET
admet-42	83	42	concentration	concentration	NOUN
admet-42	83	43	of	of	ADP
admet-42	83	44	the	the	DET
admet-42	83	45	chemical	chemical	NOUN
admet-42	83	46	compound	compound	NOUN
admet-42	83	47	,	,	PUNCT
admet-42	83	48	cs	cs	PROPN
admet-42	83	49	,	,	PUNCT
admet-42	83	50	in	in	ADP
admet-42	83	51	the	the	DET
admet-42	83	52	stripped	strip	VERB
admet-42	83	53	skin	skin	NOUN
admet-42	83	54	at	at	ADP
admet-42	83	55	a	a	DET
admet-42	83	56	position	position	NOUN
admet-42	83	57	,	,	PUNCT
admet-42	83	58	x	x	PRON
admet-42	83	59	,	,	PUNCT
admet-42	83	60	and	and	CCONJ
admet-42	83	61	time	time	NOUN
admet-42	83	62	,	,	PUNCT
admet-42	83	63	t	t	PROPN
admet-42	83	64	,	,	PUNCT
admet-42	83	65	was	be	AUX
admet-42	83	66	expressed	express	VERB
admet-42	83	67	by	by	ADP
admet-42	83	68	fick	fick	PROPN
admet-42	83	69	’s	’s	PART
admet-42	83	70	2nd	2nd	ADJ
admet-42	83	71	law	law	NOUN
admet-42	83	72	of	of	ADP
admet-42	83	73	diffusion	diffusion	NOUN
admet-42	83	74	as	as	SCONJ
admet-42	83	75	follows	follow	VERB
admet-42	83	76	:	:	PUNCT
admet-42	84	1	2	2	NUM
admet-42	84	2	2	2	NUM
admet-42	84	3	s	s	NOUN
admet-42	84	4	s	s	NOUN
admet-42	84	5	s	s	X
admet-42	84	6	c	c	NOUN
admet-42	84	7	c	c	NOUN
admet-42	84	8	d	d	NOUN
admet-42	84	9	t	t	PROPN
admet-42	84	10	x	x	SYM
admet-42	84	11			ADJ
admet-42	84	12			ADJ
admet-42	84	13			PROPN
admet-42	84	14			ADJ
admet-42	84	15			ADJ
admet-42	84	16	(	(	PUNCT
admet-42	84	17	1	1	NUM
admet-42	84	18	)	)	PUNCT
admet-42	84	19	where	where	SCONJ
admet-42	84	20	ds	ds	NOUN
admet-42	84	21	is	be	AUX
admet-42	84	22	the	the	DET
admet-42	84	23	effective	effective	ADJ
admet-42	84	24	diffusion	diffusion	NOUN
admet-42	84	25	coefficient	coefficient	NOUN
admet-42	84	26	of	of	ADP
admet-42	84	27	the	the	DET
admet-42	84	28	chemical	chemical	NOUN
admet-42	84	29	compound	compound	NOUN
admet-42	84	30	in	in	ADP
admet-42	84	31	the	the	DET
admet-42	84	32	stripped	strip	VERB
admet-42	84	33	skin	skin	NOUN
admet-42	84	34	.	.	PUNCT
admet-42	85	1	the	the	DET
admet-42	85	2	initial	initial	ADJ
admet-42	85	3	condition	condition	NOUN
admet-42	85	4	(	(	PUNCT
admet-42	85	5	i.c	i.c	PROPN
admet-42	85	6	.	.	PROPN
admet-42	85	7	)	)	PUNCT
admet-42	85	8	and	and	CCONJ
admet-42	85	9	boundary	boundary	ADJ
admet-42	85	10	condition	condition	NOUN
admet-42	85	11	(	(	PUNCT
admet-42	85	12	b.c	b.c	PROPN
admet-42	85	13	.	.	PROPN
admet-42	85	14	)	)	PUNCT
admet-42	85	15	in	in	ADP
admet-42	85	16	the	the	DET
admet-42	85	17	present	present	ADJ
admet-42	85	18	study	study	NOUN
admet-42	85	19	were	be	AUX
admet-42	85	20	as	as	SCONJ
admet-42	85	21	follows	follow	VERB
admet-42	85	22	:	:	PUNCT
admet-42	85	23	i.c	i.c	PROPN
admet-42	85	24	.	.	PROPN
admet-42	85	25	t	t	PROPN
admet-42	86	1	=	=	PUNCT
admet-42	86	2	0	0	NUM
admet-42	86	3	0	0	NUM
admet-42	86	4	<	<	X
admet-42	86	5	x	x	X
admet-42	86	6	<	<	X
admet-42	86	7	l	l	X
admet-42	86	8	cs	cs	PROPN
admet-42	86	9	=	=	SYM
admet-42	86	10	0	0	NUM
admet-42	86	11	b.c	b.c	PROPN
admet-42	86	12	.	.	PROPN
admet-42	86	13	t	t	PROPN
admet-42	86	14	>	>	X
admet-42	86	15	0	0	PUNCT
admet-42	87	1	x	x	X
admet-42	87	2	=	=	SYM
admet-42	87	3	0	0	NUM
admet-42	87	4	cs	cs	PROPN
admet-42	87	5	=	=	X
admet-42	87	6	kcv	kcv	NOUN
admet-42	87	7	x	x	X
admet-42	87	8	=	=	PUNCT
admet-42	88	1	l	l	PUNCT
admet-42	88	2	cs=0	cs=0	PUNCT
admet-42	89	1	d	d	X
admet-42	89	2	s	s	PROPN
admet-42	89	3	d	d	X
admet-42	89	4	s	s	X
admet-42	89	5	dc	dc	PROPN
admet-42	89	6	dc	dc	PROPN
admet-42	89	7	v	v	X
admet-42	89	8	ad	ad	ADV
admet-42	89	9	dt	dt	X
admet-42	89	10	dx	dx	PROPN
admet-42	89	11			PROPN
admet-42	89	12	(	(	PUNCT
admet-42	89	13	2	2	NUM
admet-42	89	14	)	)	PUNCT
admet-42	89	15	sugibayashi	sugibayashi	NOUN
admet-42	89	16	et.al	et.al	PROPN
admet-42	89	17	.	.	PUNCT
admet-42	90	1	admet	admet	PROPN
admet-42	90	2	&	&	CCONJ
admet-42	90	3	dmpk	dmpk	PROPN
admet-42	90	4	2(4	2(4	NUM
admet-42	90	5	)	)	PUNCT
admet-42	90	6	(	(	PUNCT
admet-42	90	7	2014	2014	NUM
admet-42	90	8	)	)	PUNCT
admet-42	90	9	221	221	NUM
admet-42	90	10	-	-	SYM
admet-42	90	11	234	234	NUM
admet-42	90	12	224	224	NUM
admet-42	90	13	where	where	SCONJ
admet-42	90	14	l	l	NOUN
admet-42	90	15	is	be	AUX
admet-42	90	16	the	the	DET
admet-42	90	17	thickness	thickness	NOUN
admet-42	90	18	of	of	ADP
admet-42	90	19	the	the	DET
admet-42	90	20	stripped	strip	VERB
admet-42	90	21	pig	pig	NOUN
admet-42	90	22	ear	ear	NOUN
admet-42	90	23	skin	skin	NOUN
admet-42	90	24	(	(	PUNCT
admet-42	90	25	1000	1000	NUM
admet-42	90	26	μm	μm	NUM
admet-42	90	27	)	)	PUNCT
admet-42	90	28	,	,	PUNCT
admet-42	90	29	k	k	PROPN
admet-42	90	30	is	be	AUX
admet-42	90	31	the	the	DET
admet-42	90	32	partition	partition	NOUN
admet-42	90	33	coefficient	coefficient	NOUN
admet-42	90	34	of	of	ADP
admet-42	90	35	the	the	DET
admet-42	90	36	chemical	chemical	NOUN
admet-42	90	37	compound	compound	NOUN
admet-42	90	38	from	from	ADP
admet-42	90	39	the	the	DET
admet-42	90	40	donor	donor	NOUN
admet-42	90	41	solution	solution	NOUN
admet-42	90	42	to	to	ADP
admet-42	90	43	the	the	DET
admet-42	90	44	stripped	strip	VERB
admet-42	90	45	skin	skin	NOUN
admet-42	90	46	,	,	PUNCT
admet-42	90	47	cv	cv	PROPN
admet-42	90	48	is	be	AUX
admet-42	90	49	the	the	DET
admet-42	90	50	chemical	chemical	NOUN
admet-42	90	51	compound	compound	NOUN
admet-42	90	52	concentration	concentration	NOUN
admet-42	90	53	in	in	ADP
admet-42	90	54	the	the	DET
admet-42	90	55	donor	donor	NOUN
admet-42	90	56	solution	solution	NOUN
admet-42	90	57	,	,	PUNCT
admet-42	90	58	vd	vd	NOUN
admet-42	90	59	is	be	AUX
admet-42	90	60	the	the	DET
admet-42	90	61	volume	volume	NOUN
admet-42	90	62	of	of	ADP
admet-42	90	63	the	the	DET
admet-42	90	64	donor	donor	NOUN
admet-42	90	65	solution	solution	NOUN
admet-42	90	66	,	,	PUNCT
admet-42	90	67	and	and	CCONJ
admet-42	90	68	a	a	PRON
admet-42	90	69	is	be	AUX
admet-42	90	70	the	the	DET
admet-42	90	71	effective	effective	ADJ
admet-42	90	72	permeation	permeation	NOUN
admet-42	90	73	area	area	NOUN
admet-42	90	74	of	of	ADP
admet-42	90	75	the	the	DET
admet-42	90	76	skin	skin	NOUN
admet-42	90	77	.	.	PUNCT
admet-42	91	1	the	the	DET
admet-42	91	2	left	left	ADJ
admet-42	91	3	and	and	CCONJ
admet-42	91	4	right	right	ADJ
admet-42	91	5	members	member	NOUN
admet-42	91	6	in	in	ADP
admet-42	91	7	eq	eq	ADP
admet-42	91	8	.	.	PUNCT
admet-42	92	1	(	(	PUNCT
admet-42	92	2	1	1	X
admet-42	92	3	)	)	PUNCT
admet-42	92	4	can	can	AUX
admet-42	92	5	be	be	AUX
admet-42	92	6	expressed	express	VERB
admet-42	92	7	by	by	ADP
admet-42	92	8	the	the	DET
admet-42	92	9	following	follow	VERB
admet-42	92	10	difference	difference	NOUN
admet-42	92	11	formulations	formulation	NOUN
admet-42	92	12	[	[	X
admet-42	92	13	27	27	NUM
admet-42	92	14	]	]	X
admet-42	92	15	:	:	PUNCT
admet-42	92	16			PROPN
admet-42	92	17			PROPN
admet-42	92	18	,	,	PUNCT
admet-42	92	19	,	,	PUNCT
admet-42	92	20	1	1	NUM
admet-42	92	21	,	,	PUNCT
admet-42	92	22	1i	1i	NOUN
admet-42	92	23	j	j	NOUN
admet-42	93	1	i	i	PRON
admet-42	93	2	j	j	VERB
admet-42	94	1	i	i	PRON
admet-42	94	2	j	j	PROPN
admet-42	95	1	dc	dc	PROPN
admet-42	95	2	c	c	X
admet-42	95	3	c	c	PROPN
admet-42	95	4	dt	dt	PROPN
admet-42	95	5	t	t	PROPN
admet-42	95	6			PROPN
admet-42	95	7			PROPN
admet-42	95	8			NOUN
admet-42	95	9	(	(	PUNCT
admet-42	95	10	3	3	X
admet-42	95	11	)	)	PUNCT
admet-42	95	12			NOUN
admet-42	95	13			PROPN
admet-42	95	14	2	2	NUM
admet-42	95	15	,	,	PUNCT
admet-42	95	16	1	1	NUM
admet-42	95	17	,	,	PUNCT
admet-42	95	18	,	,	PUNCT
admet-42	95	19	1,2	1,2	NUM
admet-42	95	20	2	2	NUM
admet-42	95	21	d	d	SYM
admet-42	95	22	2	2	NUM
admet-42	95	23	d	d	NOUN
admet-42	95	24	i	i	PRON
admet-42	95	25	j	j	PROPN
admet-42	96	1	s	s	X
admet-42	96	2	s	s	X
admet-42	96	3	i	i	PRON
admet-42	96	4	j	j	PROPN
admet-42	97	1	i	i	PRON
admet-42	97	2	j	j	VERB
admet-42	98	1	i	i	PRON
admet-42	98	2	j	j	PROPN
admet-42	99	1	c	c	NOUN
admet-42	99	2	d	d	PROPN
admet-42	99	3	d	d	NOUN
admet-42	99	4	c	c	NOUN
admet-42	99	5	c	c	NOUN
admet-42	99	6	c	c	NOUN
admet-42	99	7	x	x	PUNCT
admet-42	99	8	x	x	PUNCT
admet-42	99	9			PROPN
admet-42	99	10			PROPN
admet-42	99	11			PROPN
admet-42	99	12			PUNCT
admet-42	99	13			X
admet-42	99	14	(	(	PUNCT
admet-42	99	15	4	4	NUM
admet-42	99	16	)	)	PUNCT
admet-42	99	17	where	where	SCONJ
admet-42	99	18	cij	cij	PROPN
admet-42	99	19	is	be	AUX
admet-42	99	20	the	the	DET
admet-42	99	21	concentration	concentration	NOUN
admet-42	99	22	of	of	ADP
admet-42	99	23	the	the	DET
admet-42	99	24	chemical	chemical	NOUN
admet-42	99	25	compound	compound	NOUN
admet-42	99	26	at	at	ADP
admet-42	99	27	the	the	DET
admet-42	99	28	i	i	PROPN
admet-42	99	29	-	-	PUNCT
admet-42	99	30	th	th	X
admet-42	99	31	position	position	NOUN
admet-42	99	32	and	and	CCONJ
admet-42	100	1	j	j	NOUN
admet-42	100	2	-	-	PUNCT
admet-42	100	3	th	th	NUM
admet-42	100	4	time	time	NOUN
admet-42	100	5	.	.	PUNCT
admet-42	101	1	δx	δx	PROPN
admet-42	101	2	is	be	AUX
admet-42	101	3	xi+1	xi+1	NOUN
admet-42	101	4	-	-	PUNCT
admet-42	101	5	xi	xi	PROPN
admet-42	101	6	and	and	CCONJ
admet-42	101	7	δt	δt	PROPN
admet-42	101	8	is	be	AUX
admet-42	101	9	tj+1	tj+1	NOUN
admet-42	101	10	-	-	PUNCT
admet-42	101	11	tj	tj	NOUN
admet-42	101	12	.	.	PUNCT
admet-42	102	1	by	by	ADP
admet-42	102	2	substituting	substitute	VERB
admet-42	102	3	eqs.(3	eqs.(3	NOUN
admet-42	102	4	)	)	PUNCT
admet-42	102	5	and	and	CCONJ
admet-42	102	6	(	(	PUNCT
admet-42	102	7	4	4	NUM
admet-42	102	8	)	)	PUNCT
admet-42	102	9	into	into	ADP
admet-42	102	10	eq	eq	NOUN
admet-42	102	11	.	.	PUNCT
admet-42	103	1	(	(	PUNCT
admet-42	103	2	1	1	NUM
admet-42	103	3	)	)	PUNCT
admet-42	103	4	,	,	PUNCT
admet-42	103	5	the	the	DET
admet-42	103	6	following	follow	VERB
admet-42	103	7	equation	equation	NOUN
admet-42	103	8	was	be	AUX
admet-42	103	9	obtained	obtain	VERB
admet-42	103	10	.	.	PUNCT
admet-42	104	1			NOUN
admet-42	104	2			PROPN
admet-42	104	3	,	,	PUNCT
admet-42	104	4	1	1	NUM
admet-42	104	5	1	1	NUM
admet-42	104	6	,	,	PUNCT
admet-42	104	7	,	,	PUNCT
admet-42	104	8	1	1	NUM
admet-42	104	9	,	,	PUNCT
admet-42	104	10	1	1	NUM
admet-42	104	11	2	2	NUM
admet-42	105	1	i	i	PRON
admet-42	105	2	j	j	VERB
admet-42	106	1	i	i	PRON
admet-42	106	2	j	j	VERB
admet-42	107	1	i	i	PRON
admet-42	107	2	j	j	VERB
admet-42	108	1	i	i	PRON
admet-42	108	2	js	js	VERB
admet-42	108	3	s	s	X
admet-42	108	4	s	s	NOUN
admet-42	108	5	s	s	X
admet-42	108	6	s	s	X
admet-42	108	7	s	s	X
admet-42	108	8	sc	sc	PROPN
admet-42	108	9	rd	rd	PROPN
admet-42	108	10	c	c	PROPN
admet-42	108	11	rd	rd	PROPN
admet-42	108	12	c	c	PROPN
admet-42	108	13	rd	rd	PROPN
admet-42	108	14	c	c	PROPN
admet-42	108	15			PUNCT
admet-42	108	16			PROPN
admet-42	108	17			PROPN
admet-42	108	18			NUM
admet-42	108	19			ADJ
admet-42	108	20			PROPN
admet-42	108	21			X
admet-42	108	22	(	(	PUNCT
admet-42	108	23	5	5	NUM
admet-42	108	24	)	)	PUNCT
admet-42	108	25	where	where	SCONJ
admet-42	108	26	r	r	NOUN
admet-42	108	27	shows	show	VERB
admet-42	108	28	∆t/∆x2	∆t/∆x2	PRON
admet-42	108	29	.	.	PUNCT
admet-42	109	1	the	the	DET
admet-42	109	2	concentration	concentration	NOUN
admet-42	109	3	of	of	ADP
admet-42	109	4	fd-4	fd-4	NOUN
admet-42	109	5	in	in	ADP
admet-42	109	6	the	the	DET
admet-42	109	7	stripped	strip	VERB
admet-42	109	8	pig	pig	NOUN
admet-42	109	9	ear	ear	NOUN
admet-42	109	10	skin	skin	NOUN
admet-42	109	11	was	be	AUX
admet-42	109	12	obtained	obtain	VERB
admet-42	109	13	by	by	ADP
admet-42	109	14	a	a	DET
admet-42	109	15	curve	curve	NOUN
admet-42	109	16	fitting	fit	VERB
admet-42	109	17	the	the	DET
admet-42	109	18	cumulative	cumulative	ADJ
admet-42	109	19	amount	amount	NOUN
admet-42	109	20	of	of	ADP
admet-42	109	21	fd-4	fd-4	NOUN
admet-42	109	22	that	that	PRON
admet-42	109	23	permeated	permeate	VERB
admet-42	109	24	through	through	ADP
admet-42	109	25	the	the	DET
admet-42	109	26	stripped	strip	VERB
admet-42	109	27	skin	skin	NOUN
admet-42	109	28	to	to	ADP
admet-42	109	29	the	the	DET
admet-42	109	30	theoretical	theoretical	ADJ
admet-42	109	31	values	value	NOUN
admet-42	109	32	using	use	VERB
admet-42	109	33	a	a	DET
admet-42	109	34	least	least	ADJ
admet-42	109	35	squares	square	NOUN
admet-42	109	36	method	method	NOUN
admet-42	109	37	.	.	PUNCT
admet-42	110	1	the	the	DET
admet-42	110	2	least	least	ADJ
admet-42	110	3	squares	square	NOUN
admet-42	110	4	calculation	calculation	NOUN
admet-42	110	5	was	be	AUX
admet-42	110	6	performed	perform	VERB
admet-42	110	7	using	use	VERB
admet-42	110	8	the	the	DET
admet-42	110	9	spreadsheet	spreadsheet	PROPN
admet-42	110	10	software	software	PROPN
admet-42	110	11	microsoft	microsoft	PROPN
admet-42	110	12	ⓡ	ⓡ	PROPN
admet-42	110	13	excel	excel	VERB
admet-42	110	14	and	and	CCONJ
admet-42	110	15	∆t	∆t	PROPN
admet-42	110	16	and	and	CCONJ
admet-42	110	17	∆x	∆x	PROPN
admet-42	110	18	were	be	AUX
admet-42	110	19	set	set	VERB
admet-42	110	20	where	where	SCONJ
admet-42	110	21	dsr	dsr	NOUN
admet-42	110	22	may	may	AUX
admet-42	110	23	become	become	VERB
admet-42	110	24	0.5	0.5	NUM
admet-42	110	25	or	or	CCONJ
admet-42	110	26	less	less	ADJ
admet-42	110	27	.	.	PUNCT
admet-42	111	1	experimental	experimental	ADJ
admet-42	111	2	materials	material	NOUN
admet-42	111	3	and	and	CCONJ
admet-42	111	4	methods	method	NOUN
admet-42	111	5	fd-4	fd-4	NUM
admet-42	111	6	was	be	AUX
admet-42	111	7	obtained	obtain	VERB
admet-42	111	8	from	from	ADP
admet-42	111	9	sigma	sigma	PROPN
admet-42	111	10	-	-	PUNCT
admet-42	111	11	aldrich	aldrich	PROPN
admet-42	111	12	(	(	PUNCT
admet-42	111	13	st	st	PROPN
admet-42	111	14	.	.	PROPN
admet-42	111	15	louis	louis	PROPN
admet-42	111	16	,	,	PUNCT
admet-42	111	17	mo	mo	PROPN
admet-42	111	18	,	,	PUNCT
admet-42	111	19	u.s.a	u.s.a	PROPN
admet-42	111	20	.	.	PUNCT
admet-42	111	21	)	)	PUNCT
admet-42	111	22	.	.	PUNCT
admet-42	112	1	the	the	DET
admet-42	112	2	cellophane	cellophane	NOUN
admet-42	112	3	tape	tape	NOUN
admet-42	112	4	(	(	PUNCT
admet-42	112	5	packaging	packaging	NOUN
admet-42	112	6	tape	tape	NOUN
admet-42	112	7	,	,	PUNCT
admet-42	112	8	series	series	NOUN
admet-42	112	9	405	405	NUM
admet-42	112	10	)	)	PUNCT
admet-42	112	11	used	use	VERB
admet-42	112	12	for	for	ADP
admet-42	112	13	tape	tape	NOUN
admet-42	112	14	stripping	strip	VERB
admet-42	112	15	was	be	AUX
admet-42	112	16	obtained	obtain	VERB
admet-42	112	17	from	from	ADP
admet-42	112	18	nichiban	nichiban	PROPN
admet-42	112	19	co.	co.	PROPN
admet-42	112	20	,	,	PUNCT
admet-42	112	21	ltd	ltd	PROPN
admet-42	112	22	.	.	PROPN
admet-42	113	1	(	(	PUNCT
admet-42	113	2	tokyo	tokyo	PROPN
admet-42	113	3	,	,	PUNCT
admet-42	113	4	japan	japan	PROPN
admet-42	113	5	)	)	PUNCT
admet-42	113	6	.	.	PUNCT
admet-42	114	1	other	other	ADJ
admet-42	114	2	reagents	reagent	NOUN
admet-42	114	3	and	and	CCONJ
admet-42	114	4	solvents	solvent	NOUN
admet-42	114	5	were	be	AUX
admet-42	114	6	of	of	ADP
admet-42	114	7	reagent	reagent	ADJ
admet-42	114	8	or	or	CCONJ
admet-42	114	9	hplc	hplc	NOUN
admet-42	114	10	grade	grade	NOUN
admet-42	114	11	and	and	CCONJ
admet-42	114	12	used	use	VERB
admet-42	114	13	without	without	ADP
admet-42	114	14	further	further	ADJ
admet-42	114	15	purification	purification	NOUN
admet-42	114	16	.	.	PUNCT
admet-42	115	1	experimental	experimental	ADJ
admet-42	115	2	animals	animal	NOUN
admet-42	115	3	the	the	DET
admet-42	115	4	edible	edible	ADJ
admet-42	115	5	ears	ear	NOUN
admet-42	115	6	of	of	ADP
admet-42	115	7	three	three	NUM
admet-42	115	8	yuan	yuan	NOUN
admet-42	115	9	pigs	pig	NOUN
admet-42	115	10	were	be	AUX
admet-42	115	11	obtained	obtain	VERB
admet-42	115	12	from	from	ADP
admet-42	115	13	saitama	saitama	PROPN
admet-42	115	14	experimental	experimental	ADJ
admet-42	115	15	animals	animal	NOUN
admet-42	115	16	*	*	PUNCT
admet-42	115	17	(	(	PUNCT
admet-42	115	18	sugito	sugito	PROPN
admet-42	115	19	,	,	PUNCT
admet-42	115	20	saitama	saitama	PROPN
admet-42	115	21	,	,	PUNCT
admet-42	115	22	japan	japan	PROPN
admet-42	115	23	)	)	PUNCT
admet-42	115	24	.	.	PUNCT
admet-42	116	1	animal	animal	NOUN
admet-42	116	2	experiments	experiment	NOUN
admet-42	116	3	were	be	AUX
admet-42	116	4	approved	approve	VERB
admet-42	116	5	by	by	ADP
admet-42	116	6	the	the	DET
admet-42	116	7	institutional	institutional	ADJ
admet-42	116	8	animal	animal	NOUN
admet-42	116	9	care	care	NOUN
admet-42	116	10	and	and	CCONJ
admet-42	116	11	use	use	VERB
admet-42	116	12	committee	committee	NOUN
admet-42	116	13	of	of	ADP
admet-42	116	14	josai	josai	PROPN
admet-42	116	15	university	university	PROPN
admet-42	116	16	(	(	PUNCT
admet-42	116	17	sakado	sakado	PROPN
admet-42	116	18	,	,	PUNCT
admet-42	116	19	saitama	saitama	PROPN
admet-42	116	20	,	,	PUNCT
admet-42	116	21	japan	japan	PROPN
admet-42	116	22	)	)	PUNCT
admet-42	116	23	.	.	PUNCT
admet-42	117	1	skin	skin	NOUN
admet-42	117	2	extraction	extraction	NOUN
admet-42	117	3	and	and	CCONJ
admet-42	117	4	pretreatment	pretreatment	NOUN
admet-42	117	5	the	the	DET
admet-42	117	6	skin	skin	NOUN
admet-42	117	7	used	use	VERB
admet-42	117	8	in	in	ADP
admet-42	117	9	the	the	DET
admet-42	117	10	fd-4	fd-4	NUM
admet-42	117	11	permeation	permeation	NOUN
admet-42	117	12	experiment	experiment	NOUN
admet-42	117	13	was	be	AUX
admet-42	117	14	carefully	carefully	ADV
admet-42	117	15	washed	wash	VERB
admet-42	117	16	and	and	CCONJ
admet-42	117	17	wiped	wipe	VERB
admet-42	117	18	well	well	ADV
admet-42	117	19	with	with	ADP
admet-42	117	20	distilled	distilled	ADJ
admet-42	117	21	water	water	NOUN
admet-42	117	22	,	,	PUNCT
admet-42	117	23	and	and	CCONJ
admet-42	117	24	the	the	DET
admet-42	117	25	surface	surface	NOUN
admet-42	117	26	of	of	ADP
admet-42	117	27	the	the	DET
admet-42	117	28	stratum	stratum	NOUN
admet-42	117	29	corneum	corneum	NOUN
admet-42	117	30	surface	surface	NOUN
admet-42	117	31	was	be	AUX
admet-42	117	32	tape	tape	NOUN
admet-42	117	33	-	-	PUNCT
admet-42	117	34	stripped	strip	VERB
admet-42	117	35	50	50	NUM
admet-42	117	36	times	time	NOUN
admet-42	117	37	using	use	VERB
admet-42	117	38	cellophane	cellophane	NOUN
admet-42	117	39	tape	tape	NOUN
admet-42	117	40	to	to	PART
admet-42	117	41	remove	remove	VERB
admet-42	117	42	the	the	DET
admet-42	117	43	whole	whole	ADJ
admet-42	117	44	layer	layer	NOUN
admet-42	117	45	of	of	ADP
admet-42	117	46	the	the	DET
admet-42	117	47	stratum	stratum	NOUN
admet-42	117	48	corneum	corneum	NOUN
admet-42	117	49	.	.	PUNCT
admet-42	118	1	one	one	NUM
admet-42	118	2	thousand	thousand	NUM
admet-42	118	3	-	-	PUNCT
admet-42	118	4	micrometer	micrometer	NOUN
admet-42	118	5	-	-	PUNCT
admet-42	118	6	thick	thick	ADJ
admet-42	118	7	stripped	strip	VERB
admet-42	118	8	pig	pig	NOUN
admet-42	118	9	ear	ear	NOUN
admet-42	118	10	skin	skin	NOUN
admet-42	118	11	slices	slice	NOUN
admet-42	118	12	were	be	AUX
admet-42	118	13	prepared	prepare	VERB
admet-42	118	14	using	use	VERB
admet-42	118	15	a	a	DET
admet-42	118	16	dermatome	dermatome	NOUN
admet-42	118	17	(	(	PUNCT
admet-42	118	18	acculan	acculan	NOUN
admet-42	118	19	3ti	3ti	PROPN
admet-42	118	20	dermatome	dermatome	NOUN
admet-42	118	21	,	,	PUNCT
admet-42	118	22	aesculap	aesculap	NOUN
admet-42	118	23	-	-	PUNCT
admet-42	118	24	a	a	DET
admet-42	118	25	b.	b.	PROPN
admet-42	118	26	braun	braun	PROPN
admet-42	118	27	company	company	PROPN
admet-42	118	28	,	,	PUNCT
admet-42	118	29	melsungen	melsungen	PROPN
admet-42	118	30	,	,	PUNCT
admet-42	118	31	hessen	hessen	PROPN
admet-42	118	32	,	,	PUNCT
admet-42	118	33	germany	germany	PROPN
admet-42	118	34	)	)	PUNCT
admet-42	118	35	to	to	PART
admet-42	118	36	separate	separate	VERB
admet-42	118	37	the	the	DET
admet-42	118	38	upper	upper	ADJ
admet-42	118	39	epidermis	epidermis	NOUN
admet-42	118	40	from	from	ADP
admet-42	118	41	the	the	DET
admet-42	118	42	dermis	dermis	NOUN
admet-42	118	43	and	and	CCONJ
admet-42	118	44	subcutaneous	subcutaneous	ADJ
admet-42	118	45	tissues	tissue	NOUN
admet-42	119	1	[	[	X
admet-42	119	2	28	28	NUM
admet-42	119	3	]	]	PUNCT
admet-42	119	4	.	.	PUNCT
admet-42	120	1	*	*	PUNCT
admet-42	120	2	now	now	ADV
admet-42	120	3	,	,	PUNCT
admet-42	120	4	all	all	DET
admet-42	120	5	the	the	DET
admet-42	120	6	business	business	NOUN
admet-42	120	7	was	be	AUX
admet-42	120	8	entrusted	entrust	VERB
admet-42	120	9	to	to	ADP
admet-42	120	10	the	the	DET
admet-42	120	11	tokyo	tokyo	PROPN
admet-42	120	12	laboratory	laboratory	NOUN
admet-42	120	13	animals	animal	NOUN
admet-42	120	14	(	(	PUNCT
admet-42	120	15	tokyo	tokyo	PROPN
admet-42	120	16	,	,	PUNCT
admet-42	120	17	japan	japan	PROPN
admet-42	120	18	)	)	PUNCT
admet-42	120	19	.	.	PUNCT
admet-42	121	1	admet	admet	PROPN
admet-42	121	2	&	&	CCONJ
admet-42	121	3	dmpk	dmpk	PROPN
admet-42	121	4	2(4	2(4	NUM
admet-42	121	5	)	)	PUNCT
admet-42	121	6	(	(	PUNCT
admet-42	121	7	2014	2014	NUM
admet-42	121	8	)	)	PUNCT
admet-42	121	9	221	221	NUM
admet-42	121	10	-	-	SYM
admet-42	121	11	234	234	NUM
admet-42	121	12	imaging	imaging	NOUN
admet-42	121	13	analysis	analysis	NOUN
admet-42	121	14	of	of	ADP
admet-42	121	15	topically	topically	ADV
admet-42	121	16	applied	apply	VERB
admet-42	121	17	fitc	fitc	NOUN
admet-42	121	18	-	-	PUNCT
admet-42	121	19	dextran	dextran	VERB
admet-42	121	20	doi	doi	NOUN
admet-42	121	21	:	:	PUNCT
admet-42	121	22	10.5599	10.5599	NUM
admet-42	121	23	/	/	SYM
admet-42	121	24	admet.2.4.42	admet.2.4.42	PRON
admet-42	121	25	225	225	NUM
admet-42	121	26	preparation	preparation	NOUN
admet-42	121	27	of	of	ADP
admet-42	121	28	pig	pig	NOUN
admet-42	121	29	ear	ear	VERB
admet-42	121	30	skin	skin	NOUN
admet-42	121	31	pieces	piece	NOUN
admet-42	121	32	for	for	ADP
admet-42	121	33	the	the	DET
admet-42	121	34	calibration	calibration	NOUN
admet-42	121	35	of	of	ADP
admet-42	121	36	fd-4	fd-4	NOUN
admet-42	121	37	concentrations	concentration	NOUN
admet-42	121	38	to	to	PART
admet-42	121	39	prepare	prepare	VERB
admet-42	121	40	a	a	DET
admet-42	121	41	calibration	calibration	NOUN
admet-42	121	42	curve	curve	NOUN
admet-42	121	43	for	for	ADP
admet-42	121	44	the	the	DET
admet-42	121	45	quantitative	quantitative	ADJ
admet-42	121	46	analysis	analysis	NOUN
admet-42	121	47	of	of	ADP
admet-42	121	48	fd-4	fd-4	NOUN
admet-42	121	49	,	,	PUNCT
admet-42	121	50	excised	excise	VERB
admet-42	121	51	stripped	strip	VERB
admet-42	121	52	pig	pig	NOUN
admet-42	121	53	ear	ear	NOUN
admet-42	121	54	skin	skin	NOUN
admet-42	121	55	pieces	piece	NOUN
admet-42	121	56	were	be	AUX
admet-42	121	57	cut	cut	VERB
admet-42	121	58	into	into	ADP
admet-42	121	59	an	an	DET
admet-42	121	60	appropriate	appropriate	ADJ
admet-42	121	61	size	size	NOUN
admet-42	121	62	and	and	CCONJ
admet-42	121	63	completely	completely	ADV
admet-42	121	64	immersed	immerse	VERB
admet-42	121	65	in	in	ADP
admet-42	121	66	solutions	solution	NOUN
admet-42	121	67	with	with	ADP
admet-42	121	68	different	different	ADJ
admet-42	121	69	concentrations	concentration	NOUN
admet-42	121	70	of	of	ADP
admet-42	121	71	fd-4	fd-4	PUNCT
admet-42	121	72	(	(	PUNCT
admet-42	121	73	0.05	0.05	NUM
admet-42	121	74	,	,	PUNCT
admet-42	121	75	0.50	0.50	NUM
admet-42	121	76	,	,	PUNCT
admet-42	121	77	1.00	1.00	NUM
admet-42	121	78	,	,	PUNCT
admet-42	121	79	2.50	2.50	NUM
admet-42	121	80	,	,	PUNCT
admet-42	121	81	4.00	4.00	NUM
admet-42	121	82	,	,	PUNCT
admet-42	121	83	and	and	CCONJ
admet-42	121	84	5.00	5.00	NUM
admet-42	121	85	mm	mm	NOUN
admet-42	121	86	)	)	PUNCT
admet-42	121	87	.	.	PUNCT
admet-42	122	1	as	as	ADP
admet-42	122	2	a	a	DET
admet-42	122	3	control	control	NOUN
admet-42	122	4	,	,	PUNCT
admet-42	122	5	skin	skin	NOUN
admet-42	122	6	pieces	piece	NOUN
admet-42	122	7	were	be	AUX
admet-42	122	8	immersed	immerse	VERB
admet-42	122	9	into	into	ADP
admet-42	122	10	ph	ph	ADJ
admet-42	122	11	7.4	7.4	NUM
admet-42	122	12	phosphate	phosphate	NOUN
admet-42	122	13	-	-	PUNCT
admet-42	122	14	buffered	buffer	VERB
admet-42	122	15	saline	saline	NOUN
admet-42	122	16	(	(	PUNCT
admet-42	122	17	pbs	pbs	PROPN
admet-42	122	18	)	)	PUNCT
admet-42	122	19	.	.	PUNCT
admet-42	123	1	all	all	DET
admet-42	123	2	skin	skin	NOUN
admet-42	123	3	pieces	piece	NOUN
admet-42	123	4	were	be	AUX
admet-42	123	5	removed	remove	VERB
admet-42	123	6	after	after	ADP
admet-42	123	7	24	24	NUM
admet-42	123	8	hours	hour	NOUN
admet-42	123	9	,	,	PUNCT
admet-42	123	10	embedded	embed	VERB
admet-42	123	11	in	in	ADP
admet-42	123	12	super	sup	ADJ
admet-42	123	13	cryoembedding	cryoembedde	VERB
admet-42	123	14	medium	medium	ADJ
admet-42	123	15	(	(	PUNCT
admet-42	123	16	section	section	NOUN
admet-42	123	17	-	-	PUNCT
admet-42	123	18	lab	lab	NOUN
admet-42	123	19	,	,	PUNCT
admet-42	123	20	hiroshima	hiroshima	PROPN
admet-42	123	21	,	,	PUNCT
admet-42	123	22	japan	japan	PROPN
admet-42	123	23	)	)	PUNCT
admet-42	123	24	,	,	PUNCT
admet-42	123	25	frozen	freeze	VERB
admet-42	123	26	in	in	ADP
admet-42	123	27	isopentane	isopentane	NOUN
admet-42	123	28	cooled	cool	VERB
admet-42	123	29	with	with	ADP
admet-42	123	30	dry	dry	ADJ
admet-42	123	31	ice	ice	NOUN
admet-42	123	32	to	to	ADP
admet-42	123	33	-20	-20	PROPN
admet-42	123	34	°	°	PROPN
admet-42	123	35	c	c	NOUN
admet-42	123	36	,	,	PUNCT
admet-42	123	37	and	and	CCONJ
admet-42	123	38	then	then	ADV
admet-42	123	39	stored	store	VERB
admet-42	123	40	at	at	ADP
admet-42	123	41	-30	-30	PROPN
admet-42	123	42	°	°	PROPN
admet-42	123	43	c	c	NOUN
admet-42	123	44	before	before	ADP
admet-42	123	45	further	further	ADJ
admet-42	123	46	use	use	NOUN
admet-42	123	47	.	.	PUNCT
admet-42	124	1	skin	skin	NOUN
admet-42	124	2	section	section	NOUN
admet-42	124	3	observations	observation	NOUN
admet-42	124	4	using	use	VERB
admet-42	124	5	a	a	DET
admet-42	124	6	confocal	confocal	ADJ
admet-42	124	7	laser	laser	NOUN
admet-42	124	8	scanning	scan	VERB
admet-42	124	9	microscope	microscope	NOUN
admet-42	124	10	(	(	PUNCT
admet-42	124	11	clsm	clsm	NOUN
admet-42	124	12	)	)	PUNCT
admet-42	124	13	ten	ten	NUM
admet-42	124	14	-	-	PUNCT
admet-42	124	15	micrometer	micrometer	NOUN
admet-42	124	16	-	-	PUNCT
admet-42	124	17	thick	thick	ADJ
admet-42	124	18	skin	skin	NOUN
admet-42	124	19	sections	section	NOUN
admet-42	124	20	were	be	AUX
admet-42	124	21	prepared	prepare	VERB
admet-42	124	22	in	in	ADP
admet-42	124	23	a	a	DET
admet-42	124	24	vertical	vertical	ADJ
admet-42	124	25	direction	direction	NOUN
admet-42	124	26	by	by	ADP
admet-42	124	27	a	a	DET
admet-42	124	28	cryostat	cryostat	NOUN
admet-42	124	29	(	(	PUNCT
admet-42	124	30	cm3050	cm3050	PROPN
admet-42	124	31	,	,	PUNCT
admet-42	124	32	leica	leica	PROPN
admet-42	124	33	,	,	PUNCT
admet-42	124	34	wetzler	wetzler	NOUN
admet-42	124	35	,	,	PUNCT
admet-42	124	36	hessen	hessen	PROPN
admet-42	124	37	,	,	PUNCT
admet-42	124	38	germany	germany	PROPN
admet-42	124	39	)	)	PUNCT
admet-42	124	40	using	use	VERB
admet-42	124	41	the	the	DET
admet-42	124	42	skin	skin	NOUN
admet-42	124	43	pieces	piece	NOUN
admet-42	124	44	obtained	obtain	VERB
admet-42	124	45	as	as	SCONJ
admet-42	124	46	described	describe	VERB
admet-42	124	47	in	in	ADP
admet-42	124	48	(	(	PUNCT
admet-42	124	49	3.4	3.4	NUM
admet-42	124	50	)	)	PUNCT
admet-42	124	51	.	.	PUNCT
admet-42	125	1	the	the	DET
admet-42	125	2	intensity	intensity	NOUN
admet-42	125	3	of	of	ADP
admet-42	125	4	fluorescence	fluorescence	NOUN
admet-42	125	5	was	be	AUX
admet-42	125	6	observed	observe	VERB
admet-42	125	7	in	in	ADP
admet-42	125	8	these	these	DET
admet-42	125	9	skin	skin	NOUN
admet-42	125	10	sections	section	NOUN
admet-42	125	11	by	by	ADP
admet-42	125	12	clsm	clsm	NOUN
admet-42	125	13	(	(	PUNCT
admet-42	125	14	fluoview	fluoview	NOUN
admet-42	125	15	fv1000	fv1000	NOUN
admet-42	125	16	and	and	CCONJ
admet-42	125	17	software	software	NOUN
admet-42	125	18	:	:	PUNCT
admet-42	126	1	fv10	fv10	PROPN
admet-42	126	2	-	-	PUNCT
admet-42	126	3	asw	asw	PROPN
admet-42	126	4	,	,	PUNCT
admet-42	126	5	olympus	olympus	PROPN
admet-42	126	6	,	,	PUNCT
admet-42	126	7	tokyo	tokyo	PROPN
admet-42	126	8	,	,	PUNCT
admet-42	126	9	japan	japan	PROPN
admet-42	126	10	)	)	PUNCT
admet-42	126	11	.	.	PUNCT
admet-42	127	1	the	the	DET
admet-42	127	2	clsm	clsm	NOUN
admet-42	127	3	conditions	condition	NOUN
admet-42	127	4	for	for	ADP
admet-42	127	5	fd-4	fd-4	NUM
admet-42	127	6	were	be	AUX
admet-42	127	7	as	as	SCONJ
admet-42	127	8	follows	follow	VERB
admet-42	127	9	:	:	PUNCT
admet-42	127	10	wavelength	wavelength	NOUN
admet-42	127	11	,	,	PUNCT
admet-42	127	12	473	473	NUM
admet-42	127	13	nm	nm	NOUN
admet-42	127	14	;	;	PUNCT
admet-42	127	15	scan	scan	ADJ
admet-42	127	16	speed	speed	NOUN
admet-42	127	17	,	,	PUNCT
admet-42	127	18	200	200	NUM
admet-42	127	19	μs	μs	NUM
admet-42	127	20	/	/	SYM
admet-42	127	21	pix	pix	NOUN
admet-42	127	22	;	;	PUNCT
admet-42	127	23	laser	laser	NOUN
admet-42	127	24	power	power	NOUN
admet-42	127	25	,	,	PUNCT
admet-42	127	26	1	1	NUM
admet-42	127	27	%	%	NOUN
admet-42	127	28	;	;	PUNCT
admet-42	127	29	high	high	ADJ
admet-42	127	30	voltage	voltage	NOUN
admet-42	127	31	,	,	PUNCT
admet-42	127	32	236	236	NUM
admet-42	127	33	v	v	NOUN
admet-42	127	34	;	;	PUNCT
admet-42	127	35	gain	gain	NOUN
admet-42	127	36	,	,	PUNCT
admet-42	127	37	1.125	1.125	NUM
admet-42	127	38	x	x	NOUN
admet-42	127	39	;	;	PUNCT
admet-42	127	40	and	and	CCONJ
admet-42	127	41	offset	offset	VERB
admet-42	127	42	,	,	PUNCT
admet-42	127	43	0	0	X
admet-42	127	44	.	.	X
admet-42	128	1	calculation	calculation	NOUN
admet-42	128	2	of	of	ADP
admet-42	128	3	fluorescence	fluorescence	NOUN
admet-42	128	4	intensity	intensity	NOUN
admet-42	128	5	for	for	ADP
admet-42	128	6	fd-4	fd-4	NUM
admet-42	128	7	from	from	ADP
admet-42	128	8	clsm	clsm	NOUN
admet-42	128	9	images	image	NOUN
admet-42	128	10	analysis	analysis	NOUN
admet-42	128	11	points	point	NOUN
admet-42	128	12	(	(	PUNCT
admet-42	128	13	50	50	NUM
admet-42	128	14	points	point	NOUN
admet-42	128	15	)	)	PUNCT
admet-42	128	16	were	be	AUX
admet-42	128	17	selected	select	VERB
admet-42	128	18	to	to	PART
admet-42	128	19	calculate	calculate	VERB
admet-42	128	20	the	the	DET
admet-42	128	21	fluorescence	fluorescence	NOUN
admet-42	128	22	intensity	intensity	NOUN
admet-42	128	23	for	for	ADP
admet-42	128	24	fd-4	fd-4	NUM
admet-42	128	25	from	from	ADP
admet-42	128	26	one	one	NUM
admet-42	128	27	skin	skin	NOUN
admet-42	128	28	section	section	NOUN
admet-42	128	29	,	,	PUNCT
admet-42	128	30	and	and	CCONJ
admet-42	128	31	an	an	DET
admet-42	128	32	average	average	ADJ
admet-42	128	33	value	value	NOUN
admet-42	128	34	was	be	AUX
admet-42	128	35	obtained	obtain	VERB
admet-42	128	36	from	from	ADP
admet-42	128	37	these	these	DET
admet-42	128	38	points	point	NOUN
admet-42	128	39	.	.	PUNCT
admet-42	129	1	figure	figure	NOUN
admet-42	129	2	3	3	NUM
admet-42	129	3	shows	show	VERB
admet-42	129	4	an	an	DET
admet-42	129	5	exemplified	exemplified	ADJ
admet-42	129	6	plot	plot	NOUN
admet-42	129	7	.	.	PUNCT
admet-42	130	1	the	the	DET
admet-42	130	2	intensity	intensity	NOUN
admet-42	130	3	of	of	ADP
admet-42	130	4	autofluorescence	autofluorescence	NOUN
admet-42	130	5	was	be	AUX
admet-42	130	6	obtained	obtain	VERB
admet-42	130	7	separately	separately	ADV
admet-42	130	8	from	from	ADP
admet-42	130	9	an	an	DET
admet-42	130	10	image	image	NOUN
admet-42	130	11	of	of	ADP
admet-42	130	12	a	a	DET
admet-42	130	13	skin	skin	NOUN
admet-42	130	14	section	section	NOUN
admet-42	130	15	immersed	immerse	VERB
admet-42	130	16	in	in	ADP
admet-42	130	17	pbs	pbs	PROPN
admet-42	130	18	alone	alone	ADV
admet-42	130	19	and	and	CCONJ
admet-42	130	20	was	be	AUX
admet-42	130	21	then	then	ADV
admet-42	130	22	used	use	VERB
admet-42	130	23	to	to	PART
admet-42	130	24	determine	determine	VERB
admet-42	130	25	the	the	DET
admet-42	130	26	actual	actual	ADJ
admet-42	130	27	fluorescence	fluorescence	NOUN
admet-42	130	28	intensity	intensity	NOUN
admet-42	130	29	for	for	ADP
admet-42	130	30	each	each	DET
admet-42	130	31	concentration	concentration	NOUN
admet-42	130	32	of	of	ADP
admet-42	130	33	fd-4	fd-4	NOUN
admet-42	130	34	.	.	PUNCT
admet-42	131	1	200	200	NUM
admet-42	131	2	μm	μm	NUM
admet-42	131	3	figure	figure	NOUN
admet-42	131	4	3	3	NUM
admet-42	131	5	.	.	NOUN
admet-42	131	6	example	example	NOUN
admet-42	131	7	of	of	ADP
admet-42	131	8	a	a	DET
admet-42	131	9	clsm	clsm	NOUN
admet-42	131	10	observation	observation	NOUN
admet-42	131	11	image	image	NOUN
admet-42	131	12	for	for	ADP
admet-42	131	13	the	the	DET
admet-42	131	14	calibration	calibration	NOUN
admet-42	131	15	of	of	ADP
admet-42	131	16	fd-4	fd-4	NOUN
admet-42	131	17	fluorescence	fluorescence	NOUN
admet-42	131	18	intensity	intensity	NOUN
admet-42	131	19	in	in	ADP
admet-42	131	20	stripped	strip	VERB
admet-42	131	21	pig	pig	NOUN
admet-42	131	22	ear	ear	NOUN
admet-42	131	23	skin	skin	NOUN
admet-42	131	24	stratum	stratum	PROPN
admet-42	131	25	corneum	corneum	VERB
admet-42	131	26	side	side	PROPN
admet-42	131	27	dermis	dermis	PROPN
admet-42	131	28	side	side	PROPN
admet-42	131	29	sugibayashi	sugibayashi	PROPN
admet-42	131	30	et.al	et.al	PROPN
admet-42	131	31	.	.	PUNCT
admet-42	132	1	admet	admet	PROPN
admet-42	132	2	&	&	CCONJ
admet-42	132	3	dmpk	dmpk	PROPN
admet-42	132	4	2(4	2(4	NUM
admet-42	132	5	)	)	PUNCT
admet-42	132	6	(	(	PUNCT
admet-42	132	7	2014	2014	NUM
admet-42	132	8	)	)	PUNCT
admet-42	132	9	221	221	NUM
admet-42	132	10	-	-	SYM
admet-42	132	11	234	234	NUM
admet-42	132	12	226	226	NUM
admet-42	132	13	skin	skin	NOUN
admet-42	132	14	permeation	permeation	NOUN
admet-42	132	15	experiments	experiment	NOUN
admet-42	132	16	for	for	ADP
admet-42	132	17	fd-4	fd-4	NUM
admet-42	132	18	stripped	strip	VERB
admet-42	132	19	skin	skin	NOUN
admet-42	132	20	samples	sample	NOUN
admet-42	132	21	were	be	AUX
admet-42	132	22	set	set	VERB
admet-42	132	23	in	in	ADP
admet-42	132	24	vertical	vertical	ADJ
admet-42	132	25	-	-	PUNCT
admet-42	132	26	typed	type	VERB
admet-42	132	27	diffusion	diffusion	NOUN
admet-42	132	28	cells	cell	NOUN
admet-42	132	29	(	(	PUNCT
admet-42	132	30	effective	effective	ADJ
admet-42	132	31	diffusion	diffusion	NOUN
admet-42	132	32	area	area	NOUN
admet-42	132	33	:	:	PUNCT
admet-42	132	34	1.77	1.77	NUM
admet-42	132	35	cm	cm	NOUN
admet-42	132	36	2	2	NUM
admet-42	132	37	)	)	PUNCT
admet-42	132	38	with	with	ADP
admet-42	132	39	the	the	DET
admet-42	132	40	epidermis	epidermis	NOUN
admet-42	132	41	side	side	NOUN
admet-42	132	42	facing	face	VERB
admet-42	132	43	the	the	DET
admet-42	132	44	donor	donor	NOUN
admet-42	132	45	compartment	compartment	NOUN
admet-42	132	46	.	.	PUNCT
admet-42	133	1	pbs	pbs	PROPN
admet-42	133	2	(	(	PUNCT
admet-42	133	3	ph	ph	PROPN
admet-42	133	4	7.4	7.4	NUM
admet-42	133	5	,	,	PUNCT
admet-42	133	6	1	1	NUM
admet-42	133	7	and	and	CCONJ
admet-42	133	8	6	6	NUM
admet-42	133	9	ml	ml	NOUN
admet-42	133	10	)	)	PUNCT
admet-42	133	11	was	be	AUX
admet-42	133	12	applied	apply	VERB
admet-42	133	13	to	to	ADP
admet-42	133	14	the	the	DET
admet-42	133	15	donor	donor	NOUN
admet-42	133	16	and	and	CCONJ
admet-42	133	17	receiver	receiver	ADJ
admet-42	133	18	cells	cell	NOUN
admet-42	133	19	,	,	PUNCT
admet-42	133	20	respectively	respectively	ADV
admet-42	133	21	,	,	PUNCT
admet-42	133	22	for	for	ADP
admet-42	133	23	1	1	NUM
admet-42	133	24	h	h	NOUN
admet-42	133	25	prior	prior	ADV
admet-42	133	26	to	to	ADP
admet-42	133	27	starting	start	VERB
admet-42	133	28	the	the	DET
admet-42	133	29	skin	skin	NOUN
admet-42	133	30	permeation	permeation	NOUN
admet-42	133	31	experiment	experiment	NOUN
admet-42	133	32	in	in	ADP
admet-42	133	33	order	order	NOUN
admet-42	133	34	not	not	PART
admet-42	133	35	only	only	ADV
admet-42	133	36	to	to	PART
admet-42	133	37	reduce	reduce	VERB
admet-42	133	38	the	the	DET
admet-42	133	39	influence	influence	NOUN
admet-42	133	40	of	of	ADP
admet-42	133	41	autofluorescence	autofluorescence	NOUN
admet-42	133	42	leaking	leak	VERB
admet-42	133	43	into	into	ADP
admet-42	133	44	the	the	DET
admet-42	133	45	receiver	receiver	ADJ
admet-42	133	46	side	side	NOUN
admet-42	133	47	,	,	PUNCT
admet-42	133	48	but	but	CCONJ
admet-42	133	49	also	also	ADV
admet-42	133	50	to	to	PART
admet-42	133	51	hydrate	hydrate	VERB
admet-42	133	52	the	the	DET
admet-42	133	53	skin	skin	NOUN
admet-42	133	54	.	.	PUNCT
admet-42	134	1	after	after	ADP
admet-42	134	2	recovering	recover	VERB
admet-42	134	3	pbs	pbs	NOUN
admet-42	134	4	from	from	ADP
admet-42	134	5	the	the	DET
admet-42	134	6	epidermis	epidermis	NOUN
admet-42	134	7	side	side	NOUN
admet-42	134	8	,	,	PUNCT
admet-42	134	9	the	the	DET
admet-42	134	10	same	same	ADJ
admet-42	134	11	volume	volume	NOUN
admet-42	134	12	of	of	ADP
admet-42	134	13	5	5	NUM
admet-42	134	14	mm	mm	NOUN
admet-42	134	15	fd-4	fd-4	NUM
admet-42	134	16	was	be	AUX
admet-42	134	17	added	add	VERB
admet-42	134	18	to	to	PART
admet-42	134	19	start	start	VERB
admet-42	134	20	the	the	DET
admet-42	134	21	permeation	permeation	NOUN
admet-42	134	22	experiment	experiment	NOUN
admet-42	134	23	.	.	PUNCT
admet-42	135	1	skin	skin	NOUN
admet-42	135	2	permeation	permeation	NOUN
admet-42	135	3	experiments	experiment	NOUN
admet-42	135	4	were	be	AUX
admet-42	135	5	performed	perform	VERB
admet-42	135	6	at	at	ADP
admet-42	135	7	32	32	NUM
admet-42	135	8	°	°	NOUN
admet-42	135	9	c	c	NOUN
admet-42	135	10	over	over	ADP
admet-42	135	11	5	5	NUM
admet-42	135	12	h	h	NOUN
admet-42	135	13	,	,	PUNCT
admet-42	135	14	and	and	CCONJ
admet-42	135	15	the	the	DET
admet-42	135	16	receiver	receiver	ADJ
admet-42	135	17	solution	solution	NOUN
admet-42	135	18	was	be	AUX
admet-42	135	19	continuously	continuously	ADV
admet-42	135	20	stirred	stir	VERB
admet-42	135	21	with	with	ADP
admet-42	135	22	a	a	DET
admet-42	135	23	star	star	NOUN
admet-42	135	24	-	-	PUNCT
admet-42	135	25	head	head	NOUN
admet-42	135	26	-	-	PUNCT
admet-42	135	27	type	type	NOUN
admet-42	135	28	magnetic	magnetic	ADJ
admet-42	135	29	stirrer	stirrer	NOUN
admet-42	135	30	.	.	PUNCT
admet-42	136	1	at	at	ADP
admet-42	136	2	the	the	DET
admet-42	136	3	predetermined	predetermined	ADJ
admet-42	136	4	times	time	NOUN
admet-42	136	5	,	,	PUNCT
admet-42	136	6	an	an	DET
admet-42	136	7	aliquot	aliquot	NOUN
admet-42	136	8	(	(	PUNCT
admet-42	136	9	0.5	0.5	NUM
admet-42	136	10	ml	ml	NOUN
admet-42	136	11	)	)	PUNCT
admet-42	136	12	was	be	AUX
admet-42	136	13	withdrawn	withdraw	VERB
admet-42	136	14	from	from	ADP
admet-42	136	15	the	the	DET
admet-42	136	16	receiver	receiver	ADJ
admet-42	136	17	cell	cell	NOUN
admet-42	136	18	and	and	CCONJ
admet-42	136	19	the	the	DET
admet-42	136	20	same	same	ADJ
admet-42	136	21	volume	volume	NOUN
admet-42	136	22	of	of	ADP
admet-42	136	23	pbs	pbs	PROPN
admet-42	136	24	was	be	AUX
admet-42	136	25	added	add	VERB
admet-42	136	26	to	to	ADP
admet-42	136	27	the	the	DET
admet-42	136	28	compartment	compartment	NOUN
admet-42	136	29	to	to	PART
admet-42	136	30	keep	keep	VERB
admet-42	136	31	the	the	DET
admet-42	136	32	volume	volume	NOUN
admet-42	136	33	constant	constant	ADJ
admet-42	136	34	.	.	PUNCT
admet-42	137	1	the	the	DET
admet-42	137	2	concentration	concentration	NOUN
admet-42	137	3	of	of	ADP
admet-42	137	4	fd-4	fd-4	NOUN
admet-42	137	5	in	in	ADP
admet-42	137	6	the	the	DET
admet-42	137	7	sample	sample	NOUN
admet-42	137	8	was	be	AUX
admet-42	137	9	measured	measure	VERB
admet-42	137	10	by	by	ADP
admet-42	137	11	a	a	DET
admet-42	137	12	fluorescence	fluorescence	NOUN
admet-42	137	13	spectrophotometer	spectrophotometer	NOUN
admet-42	137	14	(	(	PUNCT
admet-42	137	15	rf-5300	rf-5300	ADJ
admet-42	137	16	,	,	PUNCT
admet-42	137	17	shimadzu	shimadzu	ADJ
admet-42	137	18	corporation	corporation	NOUN
admet-42	137	19	,	,	PUNCT
admet-42	137	20	kyoto	kyoto	PROPN
admet-42	137	21	,	,	PUNCT
admet-42	137	22	japan	japan	PROPN
admet-42	137	23	)	)	PUNCT
admet-42	137	24	.	.	PUNCT
admet-42	138	1	determination	determination	NOUN
admet-42	138	2	of	of	ADP
admet-42	138	3	fd-4	fd-4	NOUN
admet-42	139	1	the	the	DET
admet-42	139	2	sample	sample	NOUN
admet-42	139	3	solution	solution	NOUN
admet-42	139	4	of	of	ADP
admet-42	139	5	fd-4	fd-4	NUM
admet-42	139	6	obtained	obtain	VERB
admet-42	139	7	from	from	ADP
admet-42	139	8	the	the	DET
admet-42	139	9	permeation	permeation	NOUN
admet-42	139	10	experiment	experiment	NOUN
admet-42	139	11	was	be	AUX
admet-42	139	12	centrifuged	centrifuge	VERB
admet-42	139	13	(	(	PUNCT
admet-42	139	14	18,800	18,800	NUM
admet-42	139	15	×g	×g	NOUN
admet-42	139	16	,	,	PUNCT
admet-42	139	17	4	4	NUM
admet-42	139	18	˚c	˚c	ADJ
admet-42	139	19	,	,	PUNCT
admet-42	139	20	5	5	NUM
admet-42	139	21	min	min	NOUN
admet-42	139	22	)	)	PUNCT
admet-42	139	23	and	and	CCONJ
admet-42	139	24	300	300	NUM
admet-42	139	25	μl	μl	ADP
admet-42	139	26	of	of	ADP
admet-42	139	27	the	the	DET
admet-42	139	28	supernatant	supernatant	NOUN
admet-42	139	29	was	be	AUX
admet-42	139	30	used	use	VERB
admet-42	139	31	for	for	ADP
admet-42	139	32	determination	determination	NOUN
admet-42	139	33	at	at	ADP
admet-42	139	34	excised	excised	ADJ
admet-42	139	35	and	and	CCONJ
admet-42	139	36	fluorescence	fluorescence	ADJ
admet-42	139	37	wavelengths	wavelength	NOUN
admet-42	139	38	of	of	ADP
admet-42	139	39	490	490	NUM
admet-42	139	40	and	and	CCONJ
admet-42	139	41	520	520	NUM
admet-42	139	42	nm	nm	NOUN
admet-42	139	43	,	,	PUNCT
admet-42	139	44	respectively	respectively	ADV
admet-42	139	45	.	.	PUNCT
admet-42	140	1	skin	skin	NOUN
admet-42	140	2	treatment	treatment	NOUN
admet-42	140	3	after	after	ADP
admet-42	140	4	the	the	DET
admet-42	140	5	skin	skin	NOUN
admet-42	140	6	permeation	permeation	NOUN
admet-42	140	7	experiment	experiment	NOUN
admet-42	140	8	for	for	ADP
admet-42	140	9	fd-4	fd-4	NOUN
admet-42	140	10	skin	skin	NOUN
admet-42	140	11	sectioning	section	VERB
admet-42	140	12	was	be	AUX
admet-42	140	13	only	only	ADV
admet-42	140	14	performed	perform	VERB
admet-42	140	15	after	after	ADP
admet-42	140	16	the	the	DET
admet-42	140	17	permeation	permeation	NOUN
admet-42	140	18	experiment	experiment	NOUN
admet-42	140	19	for	for	ADP
admet-42	140	20	fd-4	fd-4	NOUN
admet-42	140	21	.	.	PUNCT
admet-42	141	1	after	after	ADP
admet-42	141	2	the	the	DET
admet-42	141	3	permeation	permeation	NOUN
admet-42	141	4	experiment	experiment	NOUN
admet-42	141	5	,	,	PUNCT
admet-42	141	6	the	the	DET
admet-42	141	7	skin	skin	NOUN
admet-42	141	8	surface	surface	NOUN
admet-42	141	9	was	be	AUX
admet-42	141	10	washed	wash	VERB
admet-42	141	11	three	three	NUM
admet-42	141	12	times	time	NOUN
admet-42	141	13	using	use	VERB
admet-42	141	14	1	1	NUM
admet-42	141	15	ml	ml	NOUN
admet-42	141	16	of	of	ADP
admet-42	141	17	pbs	pbs	PROPN
admet-42	141	18	on	on	ADP
admet-42	141	19	the	the	DET
admet-42	141	20	franz	franz	NOUN
admet-42	141	21	-	-	PUNCT
admet-42	141	22	type	type	NOUN
admet-42	141	23	diffusion	diffusion	NOUN
admet-42	141	24	cell	cell	NOUN
admet-42	141	25	.	.	PUNCT
admet-42	142	1	the	the	DET
admet-42	142	2	skin	skin	NOUN
admet-42	142	3	sample	sample	NOUN
admet-42	142	4	taken	take	VERB
admet-42	142	5	from	from	ADP
admet-42	142	6	the	the	DET
admet-42	142	7	diffusion	diffusion	NOUN
admet-42	142	8	cell	cell	NOUN
admet-42	142	9	was	be	AUX
admet-42	142	10	cut	cut	VERB
admet-42	142	11	vertically	vertically	ADV
admet-42	142	12	using	use	VERB
admet-42	142	13	a	a	DET
admet-42	142	14	razor	razor	NOUN
admet-42	142	15	blade	blade	NOUN
admet-42	142	16	,	,	PUNCT
admet-42	142	17	embedded	embed	VERB
admet-42	142	18	in	in	ADP
admet-42	142	19	super	sup	ADJ
admet-42	142	20	cryoembedding	cryoembedde	VERB
admet-42	142	21	medium	medium	NOUN
admet-42	142	22	,	,	PUNCT
admet-42	142	23	and	and	CCONJ
admet-42	142	24	frozen	freeze	VERB
admet-42	142	25	in	in	ADP
admet-42	142	26	isopentane	isopentane	NOUN
admet-42	142	27	cooled	cool	VERB
admet-42	142	28	with	with	ADP
admet-42	142	29	dry	dry	ADJ
admet-42	142	30	ice	ice	NOUN
admet-42	142	31	.	.	PUNCT
admet-42	143	1	skin	skin	NOUN
admet-42	143	2	slices	slice	NOUN
admet-42	143	3	(	(	PUNCT
admet-42	143	4	10	10	NUM
admet-42	143	5	μm	μm	NOUN
admet-42	143	6	in	in	ADP
admet-42	143	7	thickness	thickness	NOUN
admet-42	143	8	)	)	PUNCT
admet-42	143	9	were	be	AUX
admet-42	143	10	made	make	VERB
admet-42	143	11	using	use	VERB
admet-42	143	12	a	a	DET
admet-42	143	13	cryostat	cryostat	NOUN
admet-42	143	14	and	and	CCONJ
admet-42	143	15	observed	observe	VERB
admet-42	143	16	under	under	ADP
admet-42	143	17	clsm	clsm	NOUN
admet-42	143	18	.	.	PUNCT
admet-42	144	1	the	the	DET
admet-42	144	2	clsm	clsm	NOUN
admet-42	144	3	conditions	condition	NOUN
admet-42	144	4	have	have	AUX
admet-42	144	5	already	already	ADV
admet-42	144	6	been	be	AUX
admet-42	144	7	described	describe	VERB
admet-42	144	8	above	above	ADV
admet-42	144	9	.	.	PUNCT
admet-42	145	1	image	image	NOUN
admet-42	145	2	analysis	analysis	NOUN
admet-42	145	3	of	of	ADP
admet-42	145	4	skin	skin	NOUN
admet-42	145	5	sections	section	NOUN
admet-42	145	6	using	use	VERB
admet-42	145	7	clsm	clsm	NOUN
admet-42	145	8	skin	skin	NOUN
admet-42	145	9	section	section	NOUN
admet-42	145	10	images	image	NOUN
admet-42	145	11	were	be	AUX
admet-42	145	12	obtained	obtain	VERB
admet-42	145	13	by	by	ADP
admet-42	145	14	clsm	clsm	X
admet-42	145	15	.	.	PUNCT
admet-42	146	1	six	six	NUM
admet-42	146	2	points	point	NOUN
admet-42	146	3	under	under	ADP
admet-42	146	4	one	one	NUM
admet-42	146	5	line	line	NOUN
admet-42	146	6	were	be	AUX
admet-42	146	7	plotted	plot	VERB
admet-42	146	8	from	from	ADP
admet-42	146	9	the	the	DET
admet-42	146	10	epidermis	epidermis	NOUN
admet-42	146	11	side	side	NOUN
admet-42	146	12	(	(	PUNCT
admet-42	146	13	x	x	SYM
admet-42	146	14	=	=	SYM
admet-42	146	15	0	0	NUM
admet-42	146	16	)	)	PUNCT
admet-42	146	17	onto	onto	ADP
admet-42	146	18	these	these	DET
admet-42	146	19	images	image	NOUN
admet-42	146	20	to	to	PART
admet-42	146	21	calculate	calculate	VERB
admet-42	146	22	the	the	DET
admet-42	146	23	fluorescence	fluorescence	NOUN
admet-42	146	24	intensity	intensity	NOUN
admet-42	146	25	.	.	PUNCT
admet-42	147	1	four	four	NUM
admet-42	147	2	lines	line	NOUN
admet-42	147	3	were	be	AUX
admet-42	147	4	then	then	ADV
admet-42	147	5	measured	measure	VERB
admet-42	147	6	to	to	PART
admet-42	147	7	determine	determine	VERB
admet-42	147	8	the	the	DET
admet-42	147	9	intensity	intensity	NOUN
admet-42	147	10	of	of	ADP
admet-42	147	11	fluorescence	fluorescence	NOUN
admet-42	147	12	.	.	PUNCT
admet-42	148	1	the	the	DET
admet-42	148	2	average	average	ADJ
admet-42	148	3	intensity	intensity	NOUN
admet-42	148	4	of	of	ADP
admet-42	148	5	fluorescence	fluorescence	NOUN
admet-42	148	6	was	be	AUX
admet-42	148	7	calculated	calculate	VERB
admet-42	148	8	from	from	ADP
admet-42	148	9	the	the	DET
admet-42	148	10	same	same	ADJ
admet-42	148	11	depth	depth	NOUN
admet-42	148	12	position	position	NOUN
admet-42	148	13	of	of	ADP
admet-42	148	14	the	the	DET
admet-42	148	15	plot	plot	NOUN
admet-42	148	16	.	.	PUNCT
admet-42	149	1	figure	figure	NOUN
admet-42	149	2	4	4	NUM
admet-42	149	3	shows	show	VERB
admet-42	149	4	a	a	DET
admet-42	149	5	plotting	plotting	NOUN
admet-42	149	6	example	example	NOUN
admet-42	149	7	.	.	PUNCT
admet-42	150	1	the	the	DET
admet-42	150	2	average	average	ADJ
admet-42	150	3	fluorescence	fluorescence	NOUN
admet-42	150	4	value	value	NOUN
admet-42	150	5	at	at	ADP
admet-42	150	6	each	each	DET
admet-42	150	7	depth	depth	NOUN
admet-42	150	8	was	be	AUX
admet-42	150	9	obtained	obtain	VERB
admet-42	150	10	by	by	ADP
admet-42	150	11	subtracting	subtract	VERB
admet-42	150	12	the	the	DET
admet-42	150	13	average	average	ADJ
admet-42	150	14	autofluorescence	autofluorescence	NOUN
admet-42	150	15	values	value	NOUN
admet-42	150	16	.	.	PUNCT
admet-42	151	1	analysis	analysis	NOUN
admet-42	151	2	of	of	ADP
admet-42	151	3	statistics	statistic	NOUN
admet-42	151	4	the	the	DET
admet-42	151	5	calibration	calibration	NOUN
admet-42	151	6	curve	curve	NOUN
admet-42	151	7	for	for	ADP
admet-42	151	8	the	the	DET
admet-42	151	9	concentration	concentration	NOUN
admet-42	151	10	of	of	ADP
admet-42	151	11	fd-4	fd-4	NOUN
admet-42	151	12	in	in	ADP
admet-42	151	13	skin	skin	NOUN
admet-42	151	14	sections	section	NOUN
admet-42	151	15	using	use	VERB
admet-42	151	16	clsm	clsm	NOUN
admet-42	151	17	was	be	AUX
admet-42	151	18	analyzed	analyze	VERB
admet-42	151	19	by	by	ADP
admet-42	151	20	pearson	pearson	PROPN
admet-42	151	21	’s	’s	PART
admet-42	151	22	correlation	correlation	NOUN
admet-42	151	23	coefficient	coefficient	NOUN
admet-42	151	24	(	(	PUNCT
admet-42	151	25	r2	r2	PROPN
admet-42	151	26	)	)	PUNCT
admet-42	151	27	to	to	PART
admet-42	151	28	determine	determine	VERB
admet-42	151	29	whether	whether	SCONJ
admet-42	151	30	a	a	DET
admet-42	151	31	linear	linear	ADJ
admet-42	151	32	relationship	relationship	NOUN
admet-42	151	33	existed	exist	VERB
admet-42	151	34	between	between	ADP
admet-42	151	35	the	the	DET
admet-42	151	36	intensity	intensity	NOUN
admet-42	151	37	of	of	ADP
admet-42	151	38	fluorescence	fluorescence	NOUN
admet-42	151	39	and	and	CCONJ
admet-42	151	40	concentration	concentration	NOUN
admet-42	151	41	of	of	ADP
admet-42	151	42	fd-4	fd-4	NOUN
admet-42	151	43	in	in	ADP
admet-42	151	44	the	the	DET
admet-42	151	45	skin	skin	NOUN
admet-42	151	46	sections	section	NOUN
admet-42	151	47	.	.	PUNCT
admet-42	152	1	admet	admet	PROPN
admet-42	152	2	&	&	CCONJ
admet-42	152	3	dmpk	dmpk	PROPN
admet-42	152	4	2(4	2(4	NUM
admet-42	152	5	)	)	PUNCT
admet-42	152	6	(	(	PUNCT
admet-42	152	7	2014	2014	NUM
admet-42	152	8	)	)	PUNCT
admet-42	152	9	221	221	NUM
admet-42	152	10	-	-	SYM
admet-42	152	11	234	234	NUM
admet-42	152	12	imaging	imaging	NOUN
admet-42	152	13	analysis	analysis	NOUN
admet-42	152	14	of	of	ADP
admet-42	152	15	topically	topically	ADV
admet-42	152	16	applied	apply	VERB
admet-42	152	17	fitc	fitc	NOUN
admet-42	152	18	-	-	PUNCT
admet-42	152	19	dextran	dextran	VERB
admet-42	152	20	doi	doi	NOUN
admet-42	152	21	:	:	PUNCT
admet-42	152	22	10.5599	10.5599	NUM
admet-42	152	23	/	/	SYM
admet-42	152	24	admet.2.4.42	admet.2.4.42	PRON
admet-42	152	25	227	227	NUM
admet-42	152	26	figure	figure	NOUN
admet-42	152	27	4	4	NUM
admet-42	152	28	.	.	NOUN
admet-42	152	29	example	example	NOUN
admet-42	152	30	of	of	ADP
admet-42	152	31	a	a	DET
admet-42	152	32	clsm	clsm	NOUN
admet-42	152	33	observation	observation	NOUN
admet-42	152	34	image	image	NOUN
admet-42	152	35	for	for	ADP
admet-42	152	36	fd-4	fd-4	NOUN
admet-42	152	37	fluorescence	fluorescence	NOUN
admet-42	152	38	intensity	intensity	NOUN
admet-42	152	39	in	in	ADP
admet-42	152	40	stripped	strip	VERB
admet-42	152	41	pig	pig	NOUN
admet-42	152	42	ear	ear	VERB
admet-42	152	43	skin	skin	NOUN
admet-42	152	44	after	after	ADP
admet-42	152	45	the	the	DET
admet-42	152	46	permeation	permeation	NOUN
admet-42	152	47	experiment	experiment	NOUN
admet-42	152	48	.	.	PUNCT
admet-42	153	1	dashed	dash	VERB
admet-42	153	2	line	line	NOUN
admet-42	153	3	:	:	PUNCT
admet-42	153	4	boundary	boundary	NOUN
admet-42	153	5	of	of	ADP
admet-42	153	6	the	the	DET
admet-42	153	7	skin	skin	NOUN
admet-42	153	8	results	result	VERB
admet-42	153	9	clsm	clsm	NOUN
admet-42	153	10	observations	observation	NOUN
admet-42	153	11	of	of	ADP
admet-42	153	12	pig	pig	NOUN
admet-42	153	13	ear	ear	VERB
admet-42	153	14	skin	skin	NOUN
admet-42	153	15	sections	section	NOUN
admet-42	153	16	immersed	immerse	VERB
admet-42	153	17	in	in	ADP
admet-42	153	18	solutions	solution	NOUN
admet-42	153	19	with	with	ADP
admet-42	153	20	various	various	ADJ
admet-42	153	21	concentrations	concentration	NOUN
admet-42	153	22	of	of	ADP
admet-42	153	23	fd-4	fd-4	NUM
admet-42	153	24	stripped	strip	VERB
admet-42	153	25	pig	pig	NOUN
admet-42	153	26	ear	ear	NOUN
admet-42	153	27	skin	skin	NOUN
admet-42	153	28	was	be	AUX
admet-42	153	29	observed	observe	VERB
admet-42	153	30	by	by	ADP
admet-42	153	31	clsm	clsm	NOUN
admet-42	153	32	after	after	ADP
admet-42	153	33	the	the	DET
admet-42	153	34	application	application	NOUN
admet-42	153	35	of	of	ADP
admet-42	153	36	solutions	solution	NOUN
admet-42	153	37	with	with	ADP
admet-42	153	38	different	different	ADJ
admet-42	153	39	concentrations	concentration	NOUN
admet-42	153	40	of	of	ADP
admet-42	153	41	fd-4	fd-4	NOUN
admet-42	153	42	.	.	PUNCT
admet-42	154	1	figure	figure	NOUN
admet-42	154	2	5	5	NUM
admet-42	154	3	shows	show	VERB
admet-42	154	4	clsm	clsm	NOUN
admet-42	154	5	images	image	NOUN
admet-42	154	6	of	of	ADP
admet-42	154	7	pig	pig	NOUN
admet-42	154	8	ear	ear	VERB
admet-42	154	9	skin	skin	NOUN
admet-42	154	10	sections	section	NOUN
admet-42	154	11	after	after	ADP
admet-42	154	12	their	their	PRON
admet-42	154	13	immersion	immersion	NOUN
admet-42	154	14	in	in	ADP
admet-42	154	15	solutions	solution	NOUN
admet-42	154	16	with	with	ADP
admet-42	154	17	various	various	ADJ
admet-42	154	18	concentrations	concentration	NOUN
admet-42	154	19	of	of	ADP
admet-42	154	20	fd-4	fd-4	NOUN
admet-42	154	21	.	.	PUNCT
admet-42	155	1	figure	figure	NOUN
admet-42	155	2	5	5	NUM
admet-42	155	3	g	g	NOUN
admet-42	155	4	shows	show	VERB
admet-42	155	5	the	the	DET
admet-42	155	6	control	control	NOUN
admet-42	155	7	(	(	PUNCT
admet-42	155	8	the	the	DET
admet-42	155	9	immersed	immersed	ADJ
admet-42	155	10	concentration	concentration	NOUN
admet-42	155	11	of	of	ADP
admet-42	155	12	fd-4	fd-4	NUM
admet-42	155	13	is	be	AUX
admet-42	155	14	0	0	NUM
admet-42	155	15	)	)	PUNCT
admet-42	155	16	.	.	PUNCT
admet-42	156	1	elevations	elevation	NOUN
admet-42	156	2	were	be	AUX
admet-42	156	3	observed	observe	VERB
admet-42	156	4	in	in	ADP
admet-42	156	5	the	the	DET
admet-42	156	6	intensity	intensity	NOUN
admet-42	156	7	of	of	ADP
admet-42	156	8	fluorescence	fluorescence	NOUN
admet-42	156	9	in	in	ADP
admet-42	156	10	the	the	DET
admet-42	156	11	image	image	NOUN
admet-42	156	12	with	with	ADP
admet-42	156	13	increases	increase	NOUN
admet-42	156	14	in	in	ADP
admet-42	156	15	the	the	DET
admet-42	156	16	immersed	immersed	ADJ
admet-42	156	17	concentration	concentration	NOUN
admet-42	156	18	of	of	ADP
admet-42	156	19	fd-4	fd-4	PUNCT
admet-42	156	20	(	(	PUNCT
admet-42	156	21	fig	fig	NOUN
admet-42	156	22	.	.	PUNCT
admet-42	157	1	5a→f	5a→f	NUM
admet-42	157	2	)	)	PUNCT
admet-42	157	3	.	.	PUNCT
admet-42	158	1	calibration	calibration	NOUN
admet-42	158	2	curve	curve	NOUN
admet-42	158	3	of	of	ADP
admet-42	158	4	fd-4	fd-4	NOUN
admet-42	158	5	in	in	ADP
admet-42	158	6	skin	skin	NOUN
admet-42	158	7	sections	section	NOUN
admet-42	158	8	observed	observe	VERB
admet-42	158	9	by	by	ADP
admet-42	158	10	clsm	clsm	NOUN
admet-42	158	11	figure	figure	NOUN
admet-42	158	12	6	6	NUM
admet-42	158	13	shows	show	VERB
admet-42	158	14	a	a	DET
admet-42	158	15	calibration	calibration	NOUN
admet-42	158	16	curve	curve	NOUN
admet-42	158	17	of	of	ADP
admet-42	158	18	the	the	DET
admet-42	158	19	average	average	ADJ
admet-42	158	20	intensity	intensity	NOUN
admet-42	158	21	of	of	ADP
admet-42	158	22	fluorescence	fluorescence	NOUN
admet-42	158	23	due	due	ADP
admet-42	158	24	to	to	ADP
admet-42	158	25	fd-4	fd-4	VERB
admet-42	158	26	in	in	ADP
admet-42	158	27	stripped	strip	VERB
admet-42	158	28	skin	skin	NOUN
admet-42	158	29	as	as	SCONJ
admet-42	158	30	obtained	obtain	VERB
admet-42	158	31	from	from	ADP
admet-42	158	32	clsm	clsm	NOUN
admet-42	158	33	images	image	NOUN
admet-42	158	34	(	(	PUNCT
admet-42	158	35	fig	fig	NOUN
admet-42	158	36	.	.	PUNCT
admet-42	158	37	5	5	NUM
admet-42	158	38	)	)	PUNCT
admet-42	158	39	.	.	PUNCT
admet-42	159	1	a	a	DET
admet-42	159	2	strong	strong	ADJ
admet-42	159	3	correlation	correlation	NOUN
admet-42	159	4	(	(	PUNCT
admet-42	159	5	r2=0.99636	r2=0.99636	NOUN
admet-42	159	6	)	)	PUNCT
admet-42	159	7	was	be	AUX
admet-42	159	8	observed	observe	VERB
admet-42	159	9	between	between	ADP
admet-42	159	10	the	the	DET
admet-42	159	11	intensity	intensity	NOUN
admet-42	159	12	of	of	ADP
admet-42	159	13	fluorescence	fluorescence	NOUN
admet-42	159	14	in	in	ADP
admet-42	159	15	the	the	DET
admet-42	159	16	skin	skin	NOUN
admet-42	159	17	and	and	CCONJ
admet-42	159	18	concentration	concentration	NOUN
admet-42	159	19	of	of	ADP
admet-42	159	20	fd-4	fd-4	NUM
admet-42	159	21	applied	apply	VERB
admet-42	159	22	.	.	PUNCT
admet-42	160	1	stratum	stratum	PROPN
admet-42	160	2	corneum	corneum	VERB
admet-42	160	3	side	side	PROPN
admet-42	160	4	dermis	dermis	PROPN
admet-42	160	5	side	side	PROPN
admet-42	160	6	sugibayashi	sugibayashi	PROPN
admet-42	160	7	et.al	et.al	PROPN
admet-42	160	8	.	.	PUNCT
admet-42	161	1	admet	admet	PROPN
admet-42	161	2	&	&	CCONJ
admet-42	161	3	dmpk	dmpk	PROPN
admet-42	161	4	2(4	2(4	NUM
admet-42	161	5	)	)	PUNCT
admet-42	161	6	(	(	PUNCT
admet-42	161	7	2014	2014	NUM
admet-42	161	8	)	)	PUNCT
admet-42	161	9	221	221	NUM
admet-42	161	10	-	-	SYM
admet-42	161	11	234	234	NUM
admet-42	161	12	228	228	NUM
admet-42	161	13	200	200	NUM
admet-42	161	14	μm	μm	NUM
admet-42	161	15	200	200	NUM
admet-42	161	16	μm	μm	NUM
admet-42	161	17	200	200	NUM
admet-42	161	18	μm	μm	NUM
admet-42	161	19	200	200	NUM
admet-42	161	20	μm	μm	NUM
admet-42	161	21	200	200	NUM
admet-42	161	22	μm	μm	NUM
admet-42	161	23	200	200	NUM
admet-42	161	24	μm	μm	NUM
admet-42	161	25	200	200	NUM
admet-42	161	26	μm	μm	NUM
admet-42	161	27	figure	figure	NOUN
admet-42	161	28	5	5	NUM
admet-42	161	29	.	.	PUNCT
admet-42	161	30	clsm	clsm	NOUN
admet-42	161	31	images	image	NOUN
admet-42	161	32	for	for	ADP
admet-42	161	33	fd-4	fd-4	NOUN
admet-42	161	34	fluorescence	fluorescence	NOUN
admet-42	161	35	intensity	intensity	NOUN
admet-42	161	36	in	in	ADP
admet-42	161	37	stripped	strip	VERB
admet-42	161	38	pig	pig	NOUN
admet-42	161	39	ear	ear	VERB
admet-42	161	40	skin	skin	NOUN
admet-42	161	41	after	after	ADP
admet-42	161	42	immersions	immersion	NOUN
admet-42	161	43	in	in	ADP
admet-42	161	44	solutions	solution	NOUN
admet-42	161	45	with	with	ADP
admet-42	161	46	different	different	ADJ
admet-42	161	47	concentrations	concentration	NOUN
admet-42	161	48	of	of	ADP
admet-42	161	49	fd-4	fd-4	NOUN
admet-42	161	50	.	.	PUNCT
admet-42	162	1	a	a	PRON
admet-42	162	2	)	)	PUNCT
admet-42	162	3	0.05	0.05	NUM
admet-42	162	4	mm	mm	NOUN
admet-42	162	5	(	(	PUNCT
admet-42	162	6	0.18	0.18	NUM
admet-42	162	7	mg	mg	PROPN
admet-42	162	8	/	/	SYM
admet-42	162	9	ml	ml	NOUN
admet-42	162	10	)	)	PUNCT
admet-42	162	11	,	,	PUNCT
admet-42	162	12	b	b	X
admet-42	162	13	)	)	PUNCT
admet-42	162	14	0.5	0.5	NUM
admet-42	162	15	mm	mm	NOUN
admet-42	162	16	(	(	PUNCT
admet-42	162	17	1.83	1.83	NUM
admet-42	162	18	mg	mg	NUM
admet-42	162	19	/	/	SYM
admet-42	162	20	ml	ml	NOUN
admet-42	162	21	)	)	PUNCT
admet-42	162	22	,	,	PUNCT
admet-42	162	23	c	c	X
admet-42	162	24	)	)	PUNCT
admet-42	162	25	1	1	NUM
admet-42	162	26	mm	mm	INTJ
admet-42	162	27	(	(	PUNCT
admet-42	162	28	3.67	3.67	NUM
admet-42	162	29	μg	μg	NOUN
admet-42	162	30	/	/	SYM
admet-42	162	31	ml	ml	PROPN
admet-42	162	32	)	)	PUNCT
admet-42	162	33	,	,	PUNCT
admet-42	162	34	d	d	X
admet-42	162	35	)	)	PUNCT
admet-42	162	36	2.5	2.5	NUM
admet-42	162	37	mm	mm	NOUN
admet-42	162	38	(	(	PUNCT
admet-42	162	39	9.17	9.17	NUM
admet-42	162	40	mg	mg	NUM
admet-42	162	41	/	/	SYM
admet-42	162	42	ml	ml	NOUN
admet-42	162	43	)	)	PUNCT
admet-42	162	44	,	,	PUNCT
admet-42	162	45	e	e	X
admet-42	162	46	)	)	PUNCT
admet-42	162	47	4	4	NUM
admet-42	162	48	mm	mm	NOUN
admet-42	162	49	(	(	PUNCT
admet-42	162	50	14.68	14.68	NUM
admet-42	162	51	mg	mg	PROPN
admet-42	162	52	/	/	SYM
admet-42	162	53	ml	ml	NOUN
admet-42	162	54	)	)	PUNCT
admet-42	162	55	,	,	PUNCT
admet-42	162	56	f	f	X
admet-42	162	57	)	)	PUNCT
admet-42	162	58	5	5	NUM
admet-42	162	59	mm	mm	NOUN
admet-42	162	60	(	(	PUNCT
admet-42	162	61	18.35	18.35	NUM
admet-42	162	62	mg	mg	NUM
admet-42	162	63	/	/	SYM
admet-42	162	64	ml	ml	NOUN
admet-42	162	65	)	)	PUNCT
admet-42	162	66	,	,	PUNCT
admet-42	162	67	g	g	NOUN
admet-42	162	68	)	)	PUNCT
admet-42	162	69	0	0	NUM
admet-42	162	70	mm	mm	INTJ
admet-42	162	71	(	(	PUNCT
admet-42	162	72	control	control	NOUN
admet-42	162	73	)	)	PUNCT
admet-42	162	74	.	.	PUNCT
admet-42	163	1	dashed	dash	VERB
admet-42	163	2	line	line	NOUN
admet-42	163	3	:	:	PUNCT
admet-42	163	4	boundary	boundary	NOUN
admet-42	163	5	of	of	ADP
admet-42	163	6	the	the	DET
admet-42	163	7	skin	skin	NOUN
admet-42	163	8	y	y	NOUN
admet-42	163	9	=	=	PUNCT
admet-42	163	10	0.0745x	0.0745x	PROPN
admet-42	164	1	+	+	NUM
admet-42	164	2	5.9233	5.9233	NUM
admet-42	164	3	r²	r²	NOUN
admet-42	164	4	=	=	SYM
admet-42	164	5	0.99636	0.99636	NUM
admet-42	164	6	0	0	NUM
admet-42	164	7	400	400	NUM
admet-42	164	8	800	800	NUM
admet-42	164	9	1200	1200	NUM
admet-42	164	10	1600	1600	NUM
admet-42	164	11	0	0	NUM
admet-42	164	12	5000	5000	NUM
admet-42	164	13	10000	10000	NUM
admet-42	164	14	15000	15000	NUM
admet-42	164	15	20000	20000	NUM
admet-42	164	16	f	f	NOUN
admet-42	164	17	lu	lu	NOUN
admet-42	164	18	o	o	X
admet-42	164	19	re	re	X
admet-42	164	20	sc	sc	PROPN
admet-42	164	21	en	en	X
admet-42	164	22	c	c	PROPN
admet-42	164	23	e	e	X
admet-42	164	24	in	in	ADP
admet-42	164	25	te	te	PROPN
admet-42	164	26	n	n	CCONJ
admet-42	164	27	si	si	NOUN
admet-42	164	28	ty	ty	INTJ
admet-42	164	29	concentration	concentration	NOUN
admet-42	164	30	(	(	PUNCT
admet-42	164	31	µg	µg	NOUN
admet-42	164	32	/	/	SYM
admet-42	164	33	ml	ml	NOUN
admet-42	164	34	)	)	PUNCT
admet-42	164	35	f	f	NOUN
admet-42	165	1	lu	lu	NOUN
admet-42	165	2	o	o	X
admet-42	165	3	re	re	VERB
admet-42	165	4	sc	sc	PROPN
admet-42	165	5	en	en	PROPN
admet-42	165	6	ce	ce	PROPN
admet-42	166	1	i	i	PROPN
admet-42	166	2	n	n	VERB
admet-42	166	3	te	te	VERB
admet-42	166	4	n	n	ADV
admet-42	166	5	si	si	INTJ
admet-42	167	1	ty	ty	INTJ
admet-42	167	2	o	o	X
admet-42	167	3	f	f	X
admet-42	167	4	c	c	NOUN
admet-42	167	5	l	l	NOUN
admet-42	167	6	s	s	PART
admet-42	167	7	m	m	VERB
admet-42	167	8	figure	figure	NOUN
admet-42	167	9	6	6	NUM
admet-42	167	10	.	.	PUNCT
admet-42	167	11	relationship	relationship	NOUN
admet-42	167	12	between	between	ADP
admet-42	167	13	fd-4	fd-4	NOUN
admet-42	167	14	fluorescence	fluorescence	NOUN
admet-42	167	15	intensity	intensity	NOUN
admet-42	167	16	observed	observe	VERB
admet-42	167	17	by	by	ADP
admet-42	167	18	clsm	clsm	NOUN
admet-42	167	19	and	and	CCONJ
admet-42	167	20	the	the	DET
admet-42	167	21	concentration	concentration	NOUN
admet-42	167	22	of	of	ADP
admet-42	167	23	fd-4	fd-4	NUM
admet-42	167	24	applied	apply	VERB
admet-42	167	25	.	.	PUNCT
admet-42	168	1	each	each	DET
admet-42	168	2	point	point	NOUN
admet-42	168	3	shows	show	VERB
admet-42	168	4	the	the	DET
admet-42	168	5	mean	mean	PROPN
admet-42	168	6	±	±	PROPN
admet-42	168	7	s.d	s.d	PROPN
admet-42	168	8	.	.	PUNCT
admet-42	169	1	(	(	PUNCT
admet-42	169	2	n	n	NOUN
admet-42	169	3	=	=	SYM
admet-42	169	4	50	50	NUM
admet-42	169	5	)	)	PUNCT
admet-42	169	6	a	a	PRON
admet-42	169	7	)	)	PUNCT
admet-42	169	8	b	b	NOUN
admet-42	169	9	)	)	PUNCT
admet-42	169	10	c	c	NOUN
admet-42	169	11	)	)	PUNCT
admet-42	169	12	d	d	NOUN
admet-42	169	13	)	)	PUNCT
admet-42	169	14	e	e	NOUN
admet-42	169	15	)	)	PUNCT
admet-42	169	16	f	f	X
admet-42	169	17	)	)	PUNCT
admet-42	169	18	g	g	NOUN
admet-42	169	19	)	)	PUNCT
admet-42	169	20	stratum	stratum	PROPN
admet-42	169	21	corneum	corneum	VERB
admet-42	169	22	side	side	PROPN
admet-42	169	23	dermis	dermis	PROPN
admet-42	169	24	side	side	PROPN
admet-42	169	25	admet	admet	PROPN
admet-42	169	26	&	&	CCONJ
admet-42	169	27	dmpk	dmpk	PROPN
admet-42	169	28	2(4	2(4	NUM
admet-42	169	29	)	)	PUNCT
admet-42	169	30	(	(	PUNCT
admet-42	169	31	2014	2014	NUM
admet-42	169	32	)	)	PUNCT
admet-42	169	33	221	221	NUM
admet-42	169	34	-	-	SYM
admet-42	169	35	234	234	NUM
admet-42	169	36	imaging	imaging	NOUN
admet-42	169	37	analysis	analysis	NOUN
admet-42	169	38	of	of	ADP
admet-42	169	39	topically	topically	ADV
admet-42	169	40	applied	apply	VERB
admet-42	169	41	fitc	fitc	NOUN
admet-42	169	42	-	-	PUNCT
admet-42	169	43	dextran	dextran	VERB
admet-42	169	44	doi	doi	NOUN
admet-42	169	45	:	:	PUNCT
admet-42	169	46	10.5599	10.5599	NUM
admet-42	169	47	/	/	SYM
admet-42	169	48	admet.2.4.42	admet.2.4.42	PROPN
admet-42	169	49	229	229	NUM
admet-42	169	50	skin	skin	NOUN
admet-42	169	51	permeation	permeation	NOUN
admet-42	169	52	and	and	CCONJ
admet-42	169	53	concentration	concentration	NOUN
admet-42	169	54	-	-	PUNCT
admet-42	169	55	distance	distance	NOUN
admet-42	169	56	profiles	profile	NOUN
admet-42	169	57	under	under	ADP
admet-42	169	58	the	the	DET
admet-42	169	59	infinite	infinite	ADJ
admet-42	169	60	condition	condition	NOUN
admet-42	169	61	an	an	DET
admet-42	169	62	in	in	ADP
admet-42	169	63	vitro	vitro	X
admet-42	169	64	skin	skin	NOUN
admet-42	169	65	permeation	permeation	NOUN
admet-42	169	66	experiment	experiment	NOUN
admet-42	169	67	was	be	AUX
admet-42	169	68	performed	perform	VERB
admet-42	169	69	to	to	PART
admet-42	169	70	further	far	ADV
admet-42	169	71	examine	examine	VERB
admet-42	169	72	the	the	DET
admet-42	169	73	permeation	permeation	NOUN
admet-42	169	74	of	of	ADP
admet-42	169	75	fd-4	fd-4	NOUN
admet-42	169	76	through	through	ADP
admet-42	169	77	stripped	strip	VERB
admet-42	169	78	pig	pig	NOUN
admet-42	169	79	ear	ear	NOUN
admet-42	169	80	skin	skin	NOUN
admet-42	169	81	.	.	PUNCT
admet-42	170	1	skin	skin	NOUN
admet-42	170	2	permeation	permeation	NOUN
admet-42	170	3	experiment	experiment	NOUN
admet-42	170	4	was	be	AUX
admet-42	170	5	performed	perform	VERB
admet-42	170	6	in	in	ADP
admet-42	170	7	three	three	NUM
admet-42	170	8	replicates	replicate	NOUN
admet-42	170	9	.	.	PUNCT
admet-42	171	1	figure	figure	NOUN
admet-42	171	2	7	7	NUM
admet-42	171	3	shows	show	VERB
admet-42	171	4	the	the	DET
admet-42	171	5	time	time	NOUN
admet-42	171	6	course	course	NOUN
admet-42	171	7	of	of	ADP
admet-42	171	8	the	the	DET
admet-42	171	9	cumulative	cumulative	ADJ
admet-42	171	10	amount	amount	NOUN
admet-42	171	11	of	of	ADP
admet-42	171	12	three	three	NUM
admet-42	171	13	individual	individual	ADJ
admet-42	171	14	profiles	profile	NOUN
admet-42	171	15	after	after	ADP
admet-42	171	16	topical	topical	ADJ
admet-42	171	17	application	application	NOUN
admet-42	171	18	of	of	ADP
admet-42	171	19	5	5	NUM
admet-42	171	20	mm	mm	NOUN
admet-42	171	21	fd-4	fd-4	NOUN
admet-42	171	22	to	to	ADP
admet-42	171	23	the	the	DET
admet-42	171	24	stripped	strip	VERB
admet-42	171	25	pig	pig	NOUN
admet-42	171	26	ear	ear	VERB
admet-42	171	27	skin	skin	NOUN
admet-42	171	28	.	.	PUNCT
admet-42	172	1	a	a	DET
admet-42	172	2	typical	typical	ADJ
admet-42	172	3	lag	lag	NOUN
admet-42	172	4	time	time	NOUN
admet-42	172	5	and	and	CCONJ
admet-42	172	6	subsequent	subsequent	ADJ
admet-42	172	7	steady	steady	ADJ
admet-42	172	8	state	state	NOUN
admet-42	172	9	skin	skin	NOUN
admet-42	172	10	permeation	permeation	NOUN
admet-42	172	11	were	be	AUX
admet-42	172	12	obtained	obtain	VERB
admet-42	172	13	.	.	PUNCT
admet-42	173	1	furthermore	furthermore	ADV
admet-42	173	2	,	,	PUNCT
admet-42	173	3	the	the	DET
admet-42	173	4	profiles	profile	NOUN
admet-42	173	5	obtained	obtain	VERB
admet-42	173	6	in	in	ADP
admet-42	173	7	three	three	NUM
admet-42	173	8	samples	sample	NOUN
admet-42	173	9	were	be	AUX
admet-42	173	10	similar	similar	ADJ
admet-42	173	11	.	.	PUNCT
admet-42	174	1	the	the	DET
admet-42	174	2	concentration	concentration	NOUN
admet-42	174	3	-	-	PUNCT
admet-42	174	4	distance	distance	NOUN
admet-42	174	5	profile	profile	NOUN
admet-42	174	6	in	in	ADP
admet-42	174	7	the	the	DET
admet-42	174	8	steady	steady	ADJ
admet-42	174	9	state	state	NOUN
admet-42	174	10	period	period	NOUN
admet-42	174	11	(	(	PUNCT
admet-42	174	12	5	5	NUM
admet-42	174	13	h	h	NOUN
admet-42	174	14	after	after	ADP
admet-42	174	15	starting	start	VERB
admet-42	174	16	the	the	DET
admet-42	174	17	permeation	permeation	NOUN
admet-42	174	18	experiment	experiment	NOUN
admet-42	174	19	)	)	PUNCT
admet-42	174	20	was	be	AUX
admet-42	174	21	determined	determine	VERB
admet-42	174	22	by	by	ADP
admet-42	174	23	the	the	DET
admet-42	174	24	permeation	permeation	NOUN
admet-42	174	25	parameters	parameter	NOUN
admet-42	174	26	of	of	ADP
admet-42	174	27	fd-4	fd-4	NUM
admet-42	174	28	from	from	ADP
admet-42	174	29	skin	skin	NOUN
admet-42	174	30	permeation	permeation	NOUN
admet-42	174	31	profiles	profile	NOUN
admet-42	174	32	using	use	VERB
admet-42	174	33	the	the	DET
admet-42	174	34	difference	difference	NOUN
admet-42	174	35	equation	equation	NOUN
admet-42	174	36	based	base	VERB
admet-42	174	37	on	on	ADP
admet-42	174	38	the	the	DET
admet-42	174	39	fick	fick	NOUN
admet-42	174	40	’s	’s	PART
admet-42	174	41	2nd	2nd	ADJ
admet-42	174	42	law	law	NOUN
admet-42	174	43	of	of	ADP
admet-42	174	44	diffusion	diffusion	NOUN
admet-42	174	45	as	as	SCONJ
admet-42	174	46	shown	show	VERB
admet-42	174	47	in	in	ADP
admet-42	174	48	the	the	DET
admet-42	174	49	methods	method	NOUN
admet-42	174	50	in	in	ADP
admet-42	174	51	the	the	DET
admet-42	174	52	subsection	subsection	NOUN
admet-42	174	53	theoretical	theoretical	ADJ
admet-42	174	54	(	(	PUNCT
admet-42	174	55	2	2	NUM
admet-42	174	56	)	)	PUNCT
admet-42	174	57	.	.	PUNCT
admet-42	175	1	the	the	DET
admet-42	175	2	calculated	calculate	VERB
admet-42	175	3	results	result	NOUN
admet-42	175	4	are	be	AUX
admet-42	175	5	shown	show	VERB
admet-42	175	6	as	as	ADP
admet-42	175	7	dashed	dash	VERB
admet-42	175	8	lines	line	NOUN
admet-42	175	9	in	in	ADP
admet-42	175	10	figure	figure	NOUN
admet-42	175	11	8	8	NUM
admet-42	175	12	.	.	NOUN
admet-42	175	13	0	0	NUM
admet-42	175	14	100	100	NUM
admet-42	175	15	200	200	NUM
admet-42	175	16	300	300	NUM
admet-42	175	17	400	400	NUM
admet-42	175	18	500	500	NUM
admet-42	175	19	0	0	NUM
admet-42	175	20	1	1	NUM
admet-42	175	21	2	2	NUM
admet-42	175	22	3	3	NUM
admet-42	175	23	4	4	NUM
admet-42	175	24	5	5	NUM
admet-42	175	25	time	time	NOUN
admet-42	175	26	(	(	PUNCT
admet-42	175	27	h	h	NOUN
admet-42	175	28	)	)	PUNCT
admet-42	175	29	c	c	VERB
admet-42	175	30	u	u	NOUN
admet-42	175	31	m	m	VERB
admet-42	175	32	u	u	NOUN
admet-42	175	33	la	la	X
admet-42	175	34	ti	ti	X
admet-42	175	35	v	v	ADP
admet-42	175	36	e	e	PROPN
admet-42	175	37	a	a	DET
admet-42	175	38	m	m	NOUN
admet-42	175	39	o	o	NOUN
admet-42	175	40	u	u	NOUN
admet-42	175	41	n	n	ADP
admet-42	175	42	t	t	NOUN
admet-42	176	1	o	o	X
admet-42	176	2	f	f	X
admet-42	176	3	f	f	PROPN
admet-42	176	4	d	d	PROPN
admet-42	176	5	-4	-4	INTJ
admet-42	176	6	(	(	PUNCT
admet-42	176	7	µ	µ	X
admet-42	176	8	g	g	NOUN
admet-42	176	9	/c	/c	SYM
admet-42	176	10	m	m	NOUN
admet-42	176	11	2	2	X
admet-42	176	12	)	)	PUNCT
admet-42	176	13	figure	figure	NOUN
admet-42	176	14	7	7	NUM
admet-42	176	15	.	.	NOUN
admet-42	176	16	time	time	NOUN
admet-42	176	17	course	course	NOUN
admet-42	176	18	of	of	ADP
admet-42	176	19	the	the	DET
admet-42	176	20	cumulative	cumulative	ADJ
admet-42	176	21	amount	amount	NOUN
admet-42	176	22	of	of	ADP
admet-42	176	23	fd-4	fd-4	NOUN
admet-42	176	24	that	that	PRON
admet-42	176	25	permeated	permeate	VERB
admet-42	176	26	through	through	ADP
admet-42	176	27	stripped	strip	VERB
admet-42	176	28	pig	pig	NOUN
admet-42	176	29	ear	ear	NOUN
admet-42	176	30	skin	skin	NOUN
admet-42	176	31	.	.	PUNCT
admet-42	177	1	●	●	X
admet-42	177	2	:	:	PUNCT
admet-42	177	3	sample	sample	NOUN
admet-42	177	4	a	a	PRON
admet-42	177	5	,	,	PUNCT
admet-42	177	6			PROPN
admet-42	177	7	:	:	PUNCT
admet-42	177	8	sample	sample	NOUN
admet-42	177	9	b	b	PROPN
admet-42	177	10	,	,	PUNCT
admet-42	177	11	▲	▲	PUNCT
admet-42	177	12	:	:	PUNCT
admet-42	177	13	sample	sample	NOUN
admet-42	177	14	c	c	PROPN
admet-42	177	15	two	two	NUM
admet-42	177	16	samples	sample	NOUN
admet-42	177	17	were	be	AUX
admet-42	177	18	selected	select	VERB
admet-42	177	19	from	from	ADP
admet-42	177	20	the	the	DET
admet-42	177	21	time	time	NOUN
admet-42	177	22	courses	course	NOUN
admet-42	177	23	of	of	ADP
admet-42	177	24	the	the	DET
admet-42	177	25	cumulative	cumulative	ADJ
admet-42	177	26	amounts	amount	NOUN
admet-42	177	27	of	of	ADP
admet-42	177	28	fd-4	fd-4	NOUN
admet-42	177	29	that	that	PRON
admet-42	177	30	permeated	permeate	VERB
admet-42	177	31	through	through	ADP
admet-42	177	32	the	the	DET
admet-42	177	33	skin	skin	NOUN
admet-42	177	34	in	in	ADP
admet-42	177	35	order	order	NOUN
admet-42	177	36	to	to	PART
admet-42	177	37	investigate	investigate	VERB
admet-42	177	38	the	the	DET
admet-42	177	39	skin	skin	NOUN
admet-42	177	40	concentration	concentration	NOUN
admet-42	177	41	-	-	PUNCT
admet-42	177	42	distance	distance	NOUN
admet-42	177	43	profile	profile	NOUN
admet-42	177	44	of	of	ADP
admet-42	177	45	fd-4	fd-4	NOUN
admet-42	177	46	in	in	ADP
admet-42	177	47	a	a	DET
admet-42	177	48	non	non	ADJ
admet-42	177	49	-	-	ADJ
admet-42	177	50	steady	steady	ADJ
admet-42	177	51	state	state	NOUN
admet-42	177	52	(	(	PUNCT
admet-42	177	53	lag	lag	NOUN
admet-42	177	54	time	time	NOUN
admet-42	177	55	period	period	NOUN
admet-42	177	56	)	)	PUNCT
admet-42	177	57	.	.	PUNCT
admet-42	178	1	dashed	dash	VERB
admet-42	178	2	lines	line	NOUN
admet-42	178	3	in	in	ADP
admet-42	178	4	figure	figure	NOUN
admet-42	178	5	9	9	NUM
admet-42	178	6	show	show	VERB
admet-42	178	7	the	the	DET
admet-42	178	8	concentration	concentration	NOUN
admet-42	178	9	-	-	PUNCT
admet-42	178	10	distance	distance	NOUN
admet-42	178	11	profile	profile	NOUN
admet-42	178	12	obtained	obtain	VERB
admet-42	178	13	in	in	ADP
admet-42	178	14	the	the	DET
admet-42	178	15	non	non	ADJ
admet-42	178	16	-	-	ADJ
admet-42	178	17	steady	steady	ADJ
admet-42	178	18	state	state	NOUN
admet-42	178	19	(	(	PUNCT
admet-42	178	20	0.5	0.5	NUM
admet-42	178	21	h	h	NOUN
admet-42	178	22	)	)	PUNCT
admet-42	178	23	,	,	PUNCT
admet-42	178	24	and	and	CCONJ
admet-42	178	25	these	these	PRON
admet-42	178	26	were	be	AUX
admet-42	178	27	calculated	calculate	VERB
admet-42	178	28	using	use	VERB
admet-42	178	29	the	the	DET
admet-42	178	30	skin	skin	NOUN
admet-42	178	31	permeation	permeation	NOUN
admet-42	178	32	parameters	parameter	NOUN
admet-42	178	33	obtained	obtain	VERB
admet-42	178	34	from	from	ADP
admet-42	178	35	the	the	DET
admet-42	178	36	permeation	permeation	NOUN
admet-42	178	37	profile	profile	NOUN
admet-42	178	38	results	result	VERB
admet-42	178	39	in	in	ADP
admet-42	178	40	figure	figure	NOUN
admet-42	178	41	7	7	NUM
admet-42	178	42	.	.	PUNCT
admet-42	179	1	the	the	DET
admet-42	179	2	results	result	NOUN
admet-42	179	3	shown	show	VERB
admet-42	179	4	by	by	ADP
admet-42	179	5	the	the	DET
admet-42	179	6	dashed	dash	VERB
admet-42	179	7	lines	line	NOUN
admet-42	179	8	in	in	ADP
admet-42	179	9	figures	figure	NOUN
admet-42	179	10	8	8	NUM
admet-42	179	11	and	and	CCONJ
admet-42	179	12	9	9	NUM
admet-42	179	13	suggested	suggest	VERB
admet-42	179	14	that	that	SCONJ
admet-42	179	15	the	the	DET
admet-42	179	16	concentration	concentration	NOUN
admet-42	179	17	-	-	PUNCT
admet-42	179	18	distance	distance	NOUN
admet-42	179	19	profiles	profile	NOUN
admet-42	179	20	of	of	ADP
admet-42	179	21	fd-4	fd-4	NOUN
admet-42	179	22	in	in	ADP
admet-42	179	23	the	the	DET
admet-42	179	24	stripped	strip	VERB
admet-42	179	25	skin	skin	NOUN
admet-42	179	26	in	in	ADP
admet-42	179	27	the	the	DET
admet-42	179	28	steady	steady	ADJ
admet-42	179	29	-	-	PUNCT
admet-42	179	30	state	state	NOUN
admet-42	179	31	and	and	CCONJ
admet-42	179	32	before	before	SCONJ
admet-42	179	33	the	the	DET
admet-42	179	34	steady	steady	ADJ
admet-42	179	35	-	-	PUNCT
admet-42	179	36	state	state	NOUN
admet-42	179	37	could	could	AUX
admet-42	179	38	be	be	AUX
admet-42	179	39	determined	determine	VERB
admet-42	179	40	from	from	ADP
admet-42	179	41	its	its	PRON
admet-42	179	42	permeation	permeation	NOUN
admet-42	179	43	profiles	profile	NOUN
admet-42	179	44	using	use	VERB
admet-42	179	45	the	the	DET
admet-42	179	46	difference	difference	NOUN
admet-42	179	47	equation	equation	NOUN
admet-42	179	48	based	base	VERB
admet-42	179	49	on	on	ADP
admet-42	179	50	the	the	DET
admet-42	179	51	fick	fick	NOUN
admet-42	179	52	’s	’s	PART
admet-42	179	53	law	law	NOUN
admet-42	179	54	.	.	PUNCT
admet-42	180	1	sugibayashi	sugibayashi	PROPN
admet-42	180	2	et.al	et.al	PROPN
admet-42	180	3	.	.	PUNCT
admet-42	181	1	admet	admet	PROPN
admet-42	181	2	&	&	CCONJ
admet-42	181	3	dmpk	dmpk	PROPN
admet-42	181	4	2(4	2(4	NUM
admet-42	181	5	)	)	PUNCT
admet-42	181	6	(	(	PUNCT
admet-42	181	7	2014	2014	NUM
admet-42	181	8	)	)	PUNCT
admet-42	181	9	221	221	NUM
admet-42	181	10	-	-	SYM
admet-42	181	11	234	234	NUM
admet-42	181	12	230	230	NUM
admet-42	181	13	0	0	NUM
admet-42	181	14	2000	2000	NUM
admet-42	181	15	4000	4000	NUM
admet-42	181	16	6000	6000	NUM
admet-42	181	17	8000	8000	NUM
admet-42	181	18	10000	10000	NUM
admet-42	181	19	0	0	NUM
admet-42	181	20	0.2	0.2	NUM
admet-42	181	21	0.4	0.4	NUM
admet-42	181	22	0.6	0.6	NUM
admet-42	181	23	0.8	0.8	NUM
admet-42	181	24	1	1	NUM
admet-42	181	25	s	s	PART
admet-42	181	26	k	k	NOUN
admet-42	181	27	in	in	ADP
admet-42	181	28	c	c	PROPN
admet-42	181	29	o	o	PROPN
admet-42	181	30	n	n	X
admet-42	181	31	ce	ce	PROPN
admet-42	181	32	n	n	CCONJ
admet-42	181	33	tr	tr	VERB
admet-42	181	34	a	a	DET
admet-42	181	35	ti	ti	NOUN
admet-42	181	36	o	o	NOUN
admet-42	181	37	n	n	ADP
admet-42	181	38	o	o	NOUN
admet-42	182	1	f	f	X
admet-42	182	2	f	f	PROPN
admet-42	183	1	d	d	PROPN
admet-42	183	2	-4	-4	INTJ
admet-42	183	3	(	(	PUNCT
admet-42	183	4	µ	µ	X
admet-42	183	5	g	g	NOUN
admet-42	183	6	/m	/m	SYM
admet-42	183	7	l	l	NOUN
admet-42	183	8	)	)	PUNCT
admet-42	183	9	distance	distance	NOUN
admet-42	183	10	ratio	ratio	NOUN
admet-42	183	11	,	,	PUNCT
admet-42	183	12	x	x	X
admet-42	183	13	0	0	NUM
admet-42	183	14	2000	2000	NUM
admet-42	183	15	4000	4000	NUM
admet-42	183	16	6000	6000	NUM
admet-42	183	17	8000	8000	NUM
admet-42	183	18	10000	10000	NUM
admet-42	183	19	0	0	NUM
admet-42	183	20	0.2	0.2	NUM
admet-42	183	21	0.4	0.4	NUM
admet-42	183	22	0.6	0.6	NUM
admet-42	183	23	0.8	0.8	NUM
admet-42	183	24	1	1	NUM
admet-42	183	25	s	s	PART
admet-42	183	26	k	k	NOUN
admet-42	183	27	in	in	ADP
admet-42	183	28	c	c	PROPN
admet-42	183	29	o	o	PROPN
admet-42	183	30	n	n	X
admet-42	183	31	ce	ce	PROPN
admet-42	183	32	n	n	CCONJ
admet-42	183	33	tr	tr	VERB
admet-42	183	34	a	a	DET
admet-42	183	35	ti	ti	NOUN
admet-42	183	36	o	o	NOUN
admet-42	183	37	n	n	ADP
admet-42	183	38	o	o	NOUN
admet-42	183	39	f	f	X
admet-42	184	1	f	f	PROPN
admet-42	184	2	d	d	PROPN
admet-42	184	3	-4	-4	INTJ
admet-42	184	4	(	(	PUNCT
admet-42	184	5	µ	µ	X
admet-42	184	6	g	g	NOUN
admet-42	184	7	/m	/m	SYM
admet-42	184	8	l	l	NOUN
admet-42	184	9	)	)	PUNCT
admet-42	184	10	distance	distance	NOUN
admet-42	184	11	ratio	ratio	NOUN
admet-42	184	12	,	,	PUNCT
admet-42	184	13	x	x	X
admet-42	184	14	0	0	NUM
admet-42	184	15	2000	2000	NUM
admet-42	184	16	4000	4000	NUM
admet-42	184	17	6000	6000	NUM
admet-42	184	18	8000	8000	NUM
admet-42	184	19	10000	10000	NUM
admet-42	184	20	0	0	NUM
admet-42	184	21	0.2	0.2	NUM
admet-42	184	22	0.4	0.4	NUM
admet-42	184	23	0.6	0.6	NUM
admet-42	184	24	0.8	0.8	NUM
admet-42	184	25	1	1	NUM
admet-42	184	26	s	s	PART
admet-42	184	27	k	k	NOUN
admet-42	184	28	in	in	ADP
admet-42	184	29	c	c	PROPN
admet-42	184	30	o	o	PROPN
admet-42	184	31	n	n	X
admet-42	184	32	ce	ce	PROPN
admet-42	184	33	n	n	CCONJ
admet-42	184	34	tr	tr	VERB
admet-42	184	35	a	a	DET
admet-42	184	36	ti	ti	NOUN
admet-42	184	37	o	o	NOUN
admet-42	184	38	n	n	ADP
admet-42	184	39	o	o	NOUN
admet-42	184	40	f	f	X
admet-42	185	1	f	f	PROPN
admet-42	185	2	d	d	PROPN
admet-42	185	3	-4	-4	INTJ
admet-42	185	4	(	(	PUNCT
admet-42	185	5	µ	µ	X
admet-42	185	6	g	g	NOUN
admet-42	185	7	/m	/m	SYM
admet-42	185	8	l	l	NOUN
admet-42	185	9	)	)	PUNCT
admet-42	185	10	distance	distance	NOUN
admet-42	185	11	ratio	ratio	NOUN
admet-42	185	12	,	,	PUNCT
admet-42	185	13	x	x	PRON
admet-42	185	14	figure	figure	VERB
admet-42	185	15	8	8	NUM
admet-42	185	16	.	.	PUNCT
admet-42	185	17	concentration	concentration	NOUN
admet-42	185	18	-	-	PUNCT
admet-42	185	19	distance	distance	NOUN
admet-42	185	20	profile	profile	NOUN
admet-42	185	21	of	of	ADP
admet-42	185	22	fd-4	fd-4	NOUN
admet-42	185	23	in	in	ADP
admet-42	185	24	the	the	DET
admet-42	185	25	steady	steady	ADJ
admet-42	185	26	state	state	NOUN
admet-42	185	27	(	(	PUNCT
admet-42	185	28	5	5	NUM
admet-42	185	29	h	h	NOUN
admet-42	185	30	)	)	PUNCT
admet-42	185	31	.	.	PUNCT
admet-42	186	1	symbols	symbol	NOUN
admet-42	186	2	(	(	PUNCT
admet-42	186	3	○	○	ADJ
admet-42	186	4	):	):	PUNCT
admet-42	186	5	observed	observe	VERB
admet-42	186	6	values	value	NOUN
admet-42	186	7	from	from	ADP
admet-42	186	8	image	image	NOUN
admet-42	186	9	analysis	analysis	NOUN
admet-42	186	10	,	,	PUNCT
admet-42	186	11	dashed	dash	VERB
admet-42	186	12	line	line	NOUN
admet-42	186	13	:	:	PUNCT
admet-42	186	14	calculated	calculate	VERB
admet-42	186	15	value	value	NOUN
admet-42	186	16	by	by	ADP
admet-42	186	17	the	the	DET
admet-42	186	18	difference	difference	NOUN
admet-42	186	19	equation	equation	NOUN
admet-42	186	20	based	base	VERB
admet-42	186	21	on	on	ADP
admet-42	186	22	fick	fick	PROPN
admet-42	186	23	’s	’s	PART
admet-42	186	24	law	law	NOUN
admet-42	186	25	of	of	ADP
admet-42	186	26	diffusion	diffusion	NOUN
admet-42	186	27	from	from	ADP
admet-42	186	28	the	the	DET
admet-42	186	29	skin	skin	NOUN
admet-42	186	30	permeation	permeation	NOUN
admet-42	186	31	profile	profile	NOUN
admet-42	186	32	.	.	PUNCT
admet-42	187	1	each	each	DET
admet-42	187	2	point	point	NOUN
admet-42	187	3	shows	show	VERB
admet-42	187	4	the	the	DET
admet-42	187	5	mean	mean	PROPN
admet-42	187	6	±	±	PROPN
admet-42	187	7	s.d	s.d	PROPN
admet-42	187	8	.	.	PUNCT
admet-42	188	1	(	(	PUNCT
admet-42	188	2	n	n	NOUN
admet-42	188	3	=	=	SYM
admet-42	188	4	4	4	NUM
admet-42	188	5	)	)	PUNCT
admet-42	188	6	.	.	PUNCT
admet-42	189	1	a	a	X
admet-42	189	2	)	)	PUNCT
admet-42	189	3	,	,	PUNCT
admet-42	189	4	b	b	NOUN
admet-42	189	5	)	)	PUNCT
admet-42	189	6	and	and	CCONJ
admet-42	189	7	c	c	X
admet-42	189	8	)	)	PUNCT
admet-42	189	9	correspond	correspond	VERB
admet-42	189	10	to	to	ADP
admet-42	189	11	samples	sample	NOUN
admet-42	189	12	a	a	DET
admet-42	189	13	,	,	PUNCT
admet-42	189	14	b	b	PROPN
admet-42	189	15	and	and	CCONJ
admet-42	189	16	c	c	NOUN
admet-42	189	17	,	,	PUNCT
admet-42	189	18	respectively	respectively	ADV
admet-42	189	19	0	0	NUM
admet-42	189	20	2000	2000	NUM
admet-42	189	21	4000	4000	NUM
admet-42	189	22	6000	6000	NUM
admet-42	189	23	8000	8000	NUM
admet-42	190	1	10000	10000	NUM
admet-42	190	2	0	0	NUM
admet-42	190	3	0.2	0.2	NUM
admet-42	190	4	0.4	0.4	NUM
admet-42	190	5	0.6	0.6	NUM
admet-42	190	6	0.8	0.8	NUM
admet-42	190	7	1	1	NUM
admet-42	190	8	s	s	PART
admet-42	190	9	k	k	NOUN
admet-42	190	10	in	in	ADP
admet-42	190	11	c	c	PROPN
admet-42	190	12	o	o	PROPN
admet-42	190	13	n	n	X
admet-42	190	14	ce	ce	PROPN
admet-42	190	15	n	n	CCONJ
admet-42	190	16	tr	tr	VERB
admet-42	190	17	a	a	DET
admet-42	190	18	ti	ti	NOUN
admet-42	190	19	o	o	NOUN
admet-42	190	20	n	n	ADP
admet-42	190	21	o	o	NOUN
admet-42	190	22	f	f	X
admet-42	190	23	f	f	PROPN
admet-42	190	24	d	d	PROPN
admet-42	190	25	-4	-4	INTJ
admet-42	190	26	(	(	PUNCT
admet-42	190	27	µ	µ	X
admet-42	190	28	g	g	NOUN
admet-42	190	29	/m	/m	SYM
admet-42	190	30	l	l	NOUN
admet-42	190	31	)	)	PUNCT
admet-42	190	32	distance	distance	NOUN
admet-42	190	33	ratio	ratio	NOUN
admet-42	190	34	,	,	PUNCT
admet-42	190	35	x	x	X
admet-42	190	36	0	0	NUM
admet-42	190	37	2000	2000	NUM
admet-42	190	38	4000	4000	NUM
admet-42	190	39	6000	6000	NUM
admet-42	190	40	8000	8000	NUM
admet-42	190	41	10000	10000	NUM
admet-42	190	42	0	0	NUM
admet-42	190	43	0.2	0.2	NUM
admet-42	190	44	0.4	0.4	NUM
admet-42	190	45	0.6	0.6	NUM
admet-42	190	46	0.8	0.8	NUM
admet-42	190	47	1	1	NUM
admet-42	190	48	s	s	PART
admet-42	190	49	k	k	NOUN
admet-42	190	50	in	in	ADP
admet-42	190	51	c	c	PROPN
admet-42	190	52	o	o	PROPN
admet-42	190	53	n	n	X
admet-42	190	54	ce	ce	PROPN
admet-42	190	55	n	n	CCONJ
admet-42	190	56	tr	tr	VERB
admet-42	190	57	a	a	DET
admet-42	190	58	ti	ti	NOUN
admet-42	190	59	o	o	NOUN
admet-42	190	60	n	n	ADP
admet-42	190	61	o	o	NOUN
admet-42	190	62	f	f	X
admet-42	191	1	f	f	PROPN
admet-42	191	2	d	d	PROPN
admet-42	191	3	-4	-4	INTJ
admet-42	191	4	(	(	PUNCT
admet-42	191	5	µ	µ	X
admet-42	191	6	g	g	NOUN
admet-42	191	7	/m	/m	SYM
admet-42	191	8	l	l	NOUN
admet-42	191	9	)	)	PUNCT
admet-42	191	10	distance	distance	NOUN
admet-42	191	11	ratio	ratio	NOUN
admet-42	191	12	,	,	PUNCT
admet-42	191	13	x	x	PRON
admet-42	191	14	figure	figure	VERB
admet-42	191	15	9	9	NUM
admet-42	191	16	.	.	PUNCT
admet-42	191	17	concentration	concentration	NOUN
admet-42	191	18	-	-	PUNCT
admet-42	191	19	distance	distance	NOUN
admet-42	191	20	profile	profile	NOUN
admet-42	191	21	of	of	ADP
admet-42	191	22	fd-4	fd-4	NOUN
admet-42	191	23	in	in	ADP
admet-42	191	24	the	the	DET
admet-42	191	25	non	non	ADJ
admet-42	191	26	-	-	ADJ
admet-42	191	27	steady	steady	ADJ
admet-42	191	28	state	state	NOUN
admet-42	191	29	(	(	PUNCT
admet-42	191	30	0.5	0.5	NUM
admet-42	191	31	)	)	PUNCT
admet-42	191	32	.	.	PUNCT
admet-42	192	1	symbols	symbol	NOUN
admet-42	192	2	(	(	PUNCT
admet-42	192	3	□	□	PUNCT
admet-42	192	4	):	):	PUNCT
admet-42	192	5	observed	observe	VERB
admet-42	192	6	value	value	NOUN
admet-42	192	7	from	from	ADP
admet-42	192	8	image	image	NOUN
admet-42	192	9	analysis	analysis	NOUN
admet-42	192	10	,	,	PUNCT
admet-42	192	11	dashed	dash	VERB
admet-42	192	12	line	line	NOUN
admet-42	192	13	:	:	PUNCT
admet-42	192	14	calculated	calculate	VERB
admet-42	192	15	value	value	NOUN
admet-42	192	16	by	by	ADP
admet-42	192	17	the	the	DET
admet-42	192	18	difference	difference	NOUN
admet-42	192	19	equation	equation	NOUN
admet-42	192	20	based	base	VERB
admet-42	192	21	on	on	ADP
admet-42	192	22	fick	fick	PROPN
admet-42	192	23	’s	’s	PART
admet-42	192	24	law	law	NOUN
admet-42	192	25	of	of	ADP
admet-42	192	26	diffusion	diffusion	NOUN
admet-42	192	27	from	from	ADP
admet-42	192	28	the	the	DET
admet-42	192	29	skin	skin	NOUN
admet-42	192	30	permeation	permeation	NOUN
admet-42	192	31	profile	profile	NOUN
admet-42	192	32	.	.	PUNCT
admet-42	193	1	each	each	DET
admet-42	193	2	point	point	NOUN
admet-42	193	3	shows	show	VERB
admet-42	193	4	the	the	DET
admet-42	193	5	mean	mean	PROPN
admet-42	193	6	±	±	PROPN
admet-42	193	7	s.d	s.d	PROPN
admet-42	193	8	.	.	PUNCT
admet-42	194	1	(	(	PUNCT
admet-42	194	2	n	n	NOUN
admet-42	194	3	=	=	SYM
admet-42	194	4	4	4	NUM
admet-42	194	5	)	)	PUNCT
admet-42	194	6	.	.	PUNCT
admet-42	195	1	a	a	X
admet-42	195	2	)	)	PUNCT
admet-42	195	3	and	and	CCONJ
admet-42	195	4	b	b	X
admet-42	195	5	)	)	PUNCT
admet-42	195	6	correspond	correspond	VERB
admet-42	195	7	to	to	ADP
admet-42	195	8	samples	sample	NOUN
admet-42	195	9	a	a	PRON
admet-42	195	10	and	and	CCONJ
admet-42	195	11	b	b	NOUN
admet-42	195	12	,	,	PUNCT
admet-42	195	13	respectively	respectively	ADV
admet-42	195	14	a	a	DET
admet-42	195	15	)	)	PUNCT
admet-42	195	16	b	b	NOUN
admet-42	195	17	)	)	PUNCT
admet-42	195	18	c	c	NOUN
admet-42	195	19	)	)	PUNCT
admet-42	195	20	a	a	DET
admet-42	195	21	)	)	PUNCT
admet-42	195	22	b	b	NOUN
admet-42	195	23	)	)	PUNCT
admet-42	195	24	admet	admet	PROPN
admet-42	195	25	&	&	CCONJ
admet-42	195	26	dmpk	dmpk	PROPN
admet-42	195	27	2(4	2(4	NUM
admet-42	195	28	)	)	PUNCT
admet-42	195	29	(	(	PUNCT
admet-42	195	30	2014	2014	NUM
admet-42	195	31	)	)	PUNCT
admet-42	195	32	221	221	NUM
admet-42	195	33	-	-	SYM
admet-42	195	34	234	234	NUM
admet-42	195	35	imaging	imaging	NOUN
admet-42	195	36	analysis	analysis	NOUN
admet-42	195	37	of	of	ADP
admet-42	195	38	topically	topically	ADV
admet-42	195	39	applied	apply	VERB
admet-42	195	40	fitc	fitc	NOUN
admet-42	195	41	-	-	PUNCT
admet-42	195	42	dextran	dextran	VERB
admet-42	195	43	doi	doi	NOUN
admet-42	195	44	:	:	PUNCT
admet-42	195	45	10.5599	10.5599	NUM
admet-42	195	46	/	/	SYM
admet-42	195	47	admet.2.4.42	admet.2.4.42	DET
admet-42	195	48	231	231	NUM
admet-42	195	49	imaging	imaging	NOUN
admet-42	195	50	analysis	analysis	NOUN
admet-42	195	51	by	by	ADP
admet-42	195	52	clsm	clsm	NOUN
admet-42	195	53	and	and	CCONJ
admet-42	195	54	comparison	comparison	NOUN
admet-42	195	55	of	of	ADP
admet-42	195	56	concentration	concentration	NOUN
admet-42	195	57	-	-	PUNCT
admet-42	195	58	distance	distance	NOUN
admet-42	195	59	profiles	profile	NOUN
admet-42	195	60	between	between	ADP
admet-42	195	61	observed	observed	ADJ
admet-42	195	62	and	and	CCONJ
admet-42	195	63	calculated	calculate	VERB
admet-42	195	64	values	value	NOUN
admet-42	195	65	the	the	DET
admet-42	195	66	intensity	intensity	NOUN
admet-42	195	67	of	of	ADP
admet-42	195	68	fluorescence	fluorescence	NOUN
admet-42	195	69	in	in	ADP
admet-42	195	70	the	the	DET
admet-42	195	71	skin	skin	NOUN
admet-42	195	72	was	be	AUX
admet-42	195	73	measured	measure	VERB
admet-42	195	74	by	by	ADP
admet-42	195	75	clsm	clsm	X
admet-42	195	76	0.5	0.5	NUM
admet-42	195	77	and	and	CCONJ
admet-42	195	78	5	5	NUM
admet-42	195	79	h	h	NOUN
admet-42	195	80	after	after	ADP
admet-42	195	81	starting	start	VERB
admet-42	195	82	the	the	DET
admet-42	195	83	in	in	ADV
admet-42	195	84	vitro	vitro	X
admet-42	195	85	skin	skin	NOUN
admet-42	195	86	permeation	permeation	NOUN
admet-42	195	87	experiment	experiment	NOUN
admet-42	195	88	.	.	PUNCT
admet-42	196	1	figures	figure	NOUN
admet-42	196	2	10	10	NUM
admet-42	196	3	and	and	CCONJ
admet-42	196	4	11	11	NUM
admet-42	196	5	show	show	VERB
admet-42	196	6	the	the	DET
admet-42	196	7	images	image	NOUN
admet-42	196	8	obtained	obtain	VERB
admet-42	196	9	of	of	ADP
admet-42	196	10	skin	skin	NOUN
admet-42	196	11	sections	section	NOUN
admet-42	196	12	for	for	ADP
admet-42	196	13	the	the	DET
admet-42	196	14	distribution	distribution	NOUN
admet-42	196	15	of	of	ADP
admet-42	196	16	fd-4	fd-4	NOUN
admet-42	196	17	5	5	NUM
admet-42	196	18	and	and	CCONJ
admet-42	196	19	0.5	0.5	NUM
admet-42	196	20	h	h	NOUN
admet-42	196	21	after	after	ADP
admet-42	196	22	the	the	DET
admet-42	196	23	skin	skin	NOUN
admet-42	196	24	permeation	permeation	NOUN
admet-42	196	25	experiment	experiment	NOUN
admet-42	196	26	(	(	PUNCT
admet-42	196	27	in	in	ADP
admet-42	196	28	the	the	DET
admet-42	196	29	steady	steady	ADJ
admet-42	196	30	and	and	CCONJ
admet-42	196	31	non	non	ADJ
admet-42	196	32	-	-	ADJ
admet-42	196	33	steady	steady	ADJ
admet-42	196	34	states	state	NOUN
admet-42	196	35	,	,	PUNCT
admet-42	196	36	respectively	respectively	ADV
admet-42	196	37	)	)	PUNCT
admet-42	196	38	.	.	PUNCT
admet-42	197	1	the	the	DET
admet-42	197	2	intensity	intensity	NOUN
admet-42	197	3	of	of	ADP
admet-42	197	4	fluorescence	fluorescence	NOUN
admet-42	197	5	for	for	ADP
admet-42	197	6	fd-4	fd-4	NUM
admet-42	197	7	on	on	ADP
admet-42	197	8	the	the	DET
admet-42	197	9	applied	applied	ADJ
admet-42	197	10	surface	surface	NOUN
admet-42	197	11	of	of	ADP
admet-42	197	12	the	the	DET
admet-42	197	13	stripped	strip	VERB
admet-42	197	14	pig	pig	NOUN
admet-42	197	15	ear	ear	NOUN
admet-42	197	16	skin	skin	NOUN
admet-42	197	17	was	be	AUX
admet-42	197	18	markedly	markedly	ADV
admet-42	197	19	high	high	ADJ
admet-42	197	20	,	,	PUNCT
admet-42	197	21	while	while	SCONJ
admet-42	197	22	that	that	SCONJ
admet-42	197	23	at	at	ADP
admet-42	197	24	the	the	DET
admet-42	197	25	receiver	receiver	ADJ
admet-42	197	26	surface	surface	NOUN
admet-42	197	27	was	be	AUX
admet-42	197	28	unstable	unstable	ADJ
admet-42	197	29	;	;	PUNCT
admet-42	197	30	therefore	therefore	ADV
admet-42	197	31	,	,	PUNCT
admet-42	197	32	it	it	PRON
admet-42	197	33	was	be	AUX
admet-42	197	34	difficult	difficult	ADJ
admet-42	197	35	to	to	PART
admet-42	197	36	quantify	quantify	VERB
admet-42	197	37	the	the	DET
admet-42	197	38	intensity	intensity	NOUN
admet-42	197	39	of	of	ADP
admet-42	197	40	fluorescence	fluorescence	NOUN
admet-42	197	41	in	in	ADP
admet-42	197	42	these	these	DET
admet-42	197	43	two	two	NUM
admet-42	197	44	surfaces	surface	NOUN
admet-42	197	45	.	.	PUNCT
admet-42	198	1	these	these	DET
admet-42	198	2	surface	surface	NOUN
admet-42	198	3	intensities	intensity	NOUN
admet-42	198	4	were	be	AUX
admet-42	198	5	subsequently	subsequently	ADV
admet-42	198	6	omitted	omit	VERB
admet-42	198	7	from	from	ADP
admet-42	198	8	the	the	DET
admet-42	198	9	fluorescence	fluorescence	NOUN
admet-42	198	10	analysis	analysis	NOUN
admet-42	198	11	.	.	PUNCT
admet-42	199	1	two	two	NUM
admet-42	199	2	images	image	NOUN
admet-42	199	3	were	be	AUX
admet-42	199	4	randomly	randomly	ADV
admet-42	199	5	selected	select	VERB
admet-42	199	6	from	from	ADP
admet-42	199	7	the	the	DET
admet-42	199	8	time	time	NOUN
admet-42	199	9	courses	course	NOUN
admet-42	199	10	of	of	ADP
admet-42	199	11	the	the	DET
admet-42	199	12	cumulative	cumulative	ADJ
admet-42	199	13	amounts	amount	NOUN
admet-42	199	14	of	of	ADP
admet-42	199	15	fd-4	fd-4	NOUN
admet-42	199	16	.	.	PUNCT
admet-42	200	1	the	the	DET
admet-42	200	2	concentration	concentration	NOUN
admet-42	200	3	-	-	PUNCT
admet-42	200	4	distance	distance	NOUN
admet-42	200	5	profiles	profile	NOUN
admet-42	200	6	for	for	ADP
admet-42	200	7	fd-4	fd-4	NUM
admet-42	200	8	in	in	ADP
admet-42	200	9	the	the	DET
admet-42	200	10	steady	steady	ADJ
admet-42	200	11	state	state	NOUN
admet-42	200	12	(	(	PUNCT
admet-42	200	13	5	5	NUM
admet-42	200	14	h	h	NOUN
admet-42	200	15	)	)	PUNCT
admet-42	200	16	and	and	CCONJ
admet-42	200	17	non	non	ADJ
admet-42	200	18	-	-	ADJ
admet-42	200	19	steady	steady	ADJ
admet-42	200	20	state	state	NOUN
admet-42	200	21	(	(	PUNCT
admet-42	200	22	0.5	0.5	NUM
admet-42	200	23	h	h	NOUN
admet-42	200	24	)	)	PUNCT
admet-42	200	25	were	be	AUX
admet-42	200	26	obtained	obtain	VERB
admet-42	200	27	from	from	ADP
admet-42	200	28	image	image	NOUN
admet-42	200	29	analysis	analysis	NOUN
admet-42	200	30	data	datum	NOUN
admet-42	200	31	by	by	ADP
admet-42	200	32	clsm	clsm	NOUN
admet-42	200	33	.	.	PUNCT
admet-42	201	1	each	each	DET
admet-42	201	2	point	point	NOUN
admet-42	201	3	in	in	ADP
admet-42	201	4	figures	figure	NOUN
admet-42	201	5	8	8	NUM
admet-42	201	6	and	and	CCONJ
admet-42	201	7	9	9	NUM
admet-42	201	8	shows	show	VERB
admet-42	201	9	the	the	DET
admet-42	201	10	concentration	concentration	NOUN
admet-42	201	11	of	of	ADP
admet-42	201	12	fd-4	fd-4	NUM
admet-42	201	13	determined	determine	VERB
admet-42	201	14	by	by	ADP
admet-42	201	15	clsm	clsm	NOUN
admet-42	201	16	imaging	imaging	NOUN
admet-42	201	17	.	.	PUNCT
admet-42	202	1	the	the	DET
admet-42	202	2	dashed	dash	VERB
admet-42	202	3	lines	line	NOUN
admet-42	202	4	in	in	ADP
admet-42	202	5	these	these	DET
admet-42	202	6	figures	figure	NOUN
admet-42	202	7	were	be	AUX
admet-42	202	8	determined	determine	VERB
admet-42	202	9	by	by	ADP
admet-42	202	10	skin	skin	NOUN
admet-42	202	11	permeation	permeation	NOUN
admet-42	202	12	data	datum	NOUN
admet-42	202	13	,	,	PUNCT
admet-42	202	14	as	as	SCONJ
admet-42	202	15	described	describe	VERB
admet-42	202	16	in	in	ADP
admet-42	202	17	(	(	PUNCT
admet-42	202	18	4	4	NUM
admet-42	202	19	.	.	NOUN
admet-42	202	20	3	3	NUM
admet-42	202	21	)	)	PUNCT
admet-42	202	22	.	.	PUNCT
admet-42	203	1	the	the	DET
admet-42	203	2	results	result	NOUN
admet-42	203	3	obtained	obtain	VERB
admet-42	203	4	by	by	ADP
admet-42	203	5	clsm	clsm	NOUN
admet-42	203	6	were	be	AUX
admet-42	203	7	similar	similar	ADJ
admet-42	203	8	to	to	ADP
admet-42	203	9	those	those	PRON
admet-42	203	10	from	from	ADP
admet-42	203	11	the	the	DET
admet-42	203	12	mathematical	mathematical	ADJ
admet-42	203	13	approach	approach	NOUN
admet-42	203	14	.	.	PUNCT
admet-42	204	1	these	these	DET
admet-42	204	2	fluorescent	fluorescent	ADJ
admet-42	204	3	gradients	gradient	NOUN
admet-42	204	4	due	due	ADP
admet-42	204	5	to	to	ADP
admet-42	204	6	the	the	DET
admet-42	204	7	permeation	permeation	NOUN
admet-42	204	8	of	of	ADP
admet-42	204	9	fd-4	fd-4	NOUN
admet-42	204	10	across	across	ADP
admet-42	204	11	the	the	DET
admet-42	204	12	skin	skin	NOUN
admet-42	204	13	in	in	ADP
admet-42	204	14	both	both	CCONJ
admet-42	204	15	the	the	DET
admet-42	204	16	steady	steady	ADJ
admet-42	204	17	state	state	NOUN
admet-42	204	18	(	(	PUNCT
admet-42	204	19	5	5	NUM
admet-42	204	20	h	h	NOUN
admet-42	204	21	)	)	PUNCT
admet-42	204	22	and	and	CCONJ
admet-42	204	23	non	non	ADJ
admet-42	204	24	-	-	ADJ
admet-42	204	25	steady	steady	ADJ
admet-42	204	26	state	state	NOUN
admet-42	204	27	(	(	PUNCT
admet-42	204	28	0.5	0.5	NUM
admet-42	204	29	h	h	NOUN
admet-42	204	30	)	)	PUNCT
admet-42	204	31	may	may	AUX
admet-42	204	32	be	be	AUX
admet-42	204	33	useful	useful	ADJ
admet-42	204	34	for	for	ADP
admet-42	204	35	visually	visually	ADV
admet-42	204	36	understanding	understand	VERB
admet-42	204	37	the	the	DET
admet-42	204	38	concentration	concentration	NOUN
admet-42	204	39	-	-	PUNCT
admet-42	204	40	distance	distance	NOUN
admet-42	204	41	profiles	profile	NOUN
admet-42	204	42	of	of	ADP
admet-42	204	43	chemical	chemical	NOUN
admet-42	204	44	compounds	compound	NOUN
admet-42	204	45	across	across	ADP
admet-42	204	46	the	the	DET
admet-42	204	47	skin	skin	NOUN
admet-42	204	48	.	.	PUNCT
admet-42	205	1	discussion	discussion	NOUN
admet-42	205	2	we	we	PRON
admet-42	205	3	used	use	VERB
admet-42	205	4	clsm	clsm	NOUN
admet-42	205	5	to	to	PART
admet-42	205	6	quantitatively	quantitatively	ADV
admet-42	205	7	determine	determine	VERB
admet-42	205	8	the	the	DET
admet-42	205	9	skin	skin	NOUN
admet-42	205	10	concentration	concentration	NOUN
admet-42	205	11	-	-	PUNCT
admet-42	205	12	distance	distance	NOUN
admet-42	205	13	profile	profile	NOUN
admet-42	205	14	of	of	ADP
admet-42	205	15	fd-4	fd-4	NOUN
admet-42	205	16	at	at	ADP
admet-42	205	17	different	different	ADJ
admet-42	205	18	depths	depth	NOUN
admet-42	205	19	through	through	ADP
admet-42	205	20	stripped	strip	VERB
admet-42	205	21	skin	skin	NOUN
admet-42	205	22	.	.	PUNCT
admet-42	206	1	limitations	limitation	NOUN
admet-42	206	2	have	have	AUX
admet-42	206	3	been	be	AUX
admet-42	206	4	associated	associate	VERB
admet-42	206	5	with	with	ADP
admet-42	206	6	the	the	DET
admet-42	206	7	conventional	conventional	ADJ
admet-42	206	8	methods	method	NOUN
admet-42	206	9	used	use	VERB
admet-42	206	10	to	to	PART
admet-42	206	11	determine	determine	VERB
admet-42	206	12	drug	drug	NOUN
admet-42	206	13	concentration	concentration	NOUN
admet-42	206	14	-	-	PUNCT
admet-42	206	15	distance	distance	NOUN
admet-42	206	16	profiles	profile	NOUN
admet-42	206	17	in	in	ADP
admet-42	206	18	the	the	DET
admet-42	206	19	skin	skin	NOUN
admet-42	206	20	.	.	PUNCT
admet-42	207	1	clsm	clsm	NOUN
admet-42	207	2	could	could	AUX
admet-42	207	3	overcome	overcome	VERB
admet-42	207	4	these	these	DET
admet-42	207	5	limitations	limitation	NOUN
admet-42	207	6	because	because	SCONJ
admet-42	207	7	it	it	PRON
admet-42	207	8	generates	generate	VERB
admet-42	207	9	high	high	ADJ
admet-42	207	10	-	-	PUNCT
admet-42	207	11	resolution	resolution	NOUN
admet-42	207	12	and	and	CCONJ
admet-42	207	13	sensitive	sensitive	ADJ
admet-42	207	14	images	image	NOUN
admet-42	207	15	at	at	ADP
admet-42	207	16	multiple	multiple	ADJ
admet-42	207	17	depths	depth	NOUN
admet-42	207	18	through	through	ADP
admet-42	207	19	the	the	DET
admet-42	207	20	skin	skin	NOUN
admet-42	207	21	without	without	ADP
admet-42	207	22	the	the	DET
admet-42	207	23	need	need	NOUN
admet-42	207	24	for	for	ADP
admet-42	207	25	mechanical	mechanical	ADJ
admet-42	207	26	skin	skin	NOUN
admet-42	207	27	sections	section	NOUN
admet-42	207	28	after	after	ADP
admet-42	207	29	the	the	DET
admet-42	207	30	topical	topical	ADJ
admet-42	207	31	application	application	NOUN
admet-42	207	32	of	of	ADP
admet-42	207	33	fluorescent	fluorescent	ADJ
admet-42	207	34	drugs	drug	NOUN
admet-42	207	35	[	[	X
admet-42	207	36	29	29	NUM
admet-42	207	37	]	]	PUNCT
admet-42	207	38	.	.	PUNCT
admet-42	208	1	we	we	PRON
admet-42	208	2	applied	apply	VERB
admet-42	208	3	a	a	DET
admet-42	208	4	wellestablished	wellestablished	ADJ
admet-42	208	5	mathematical	mathematical	ADJ
admet-42	208	6	approach	approach	NOUN
admet-42	208	7	represented	represent	VERB
admet-42	208	8	by	by	ADP
admet-42	208	9	the	the	DET
admet-42	208	10	difference	difference	NOUN
admet-42	208	11	method	method	NOUN
admet-42	208	12	based	base	VERB
admet-42	208	13	on	on	ADP
admet-42	208	14	fick	fick	PROPN
admet-42	208	15	’s	’s	PART
admet-42	208	16	law	law	NOUN
admet-42	208	17	of	of	ADP
admet-42	208	18	diffusion	diffusion	NOUN
admet-42	208	19	to	to	PART
admet-42	208	20	obtain	obtain	VERB
admet-42	208	21	the	the	DET
admet-42	208	22	skin	skin	NOUN
admet-42	208	23	concentration	concentration	NOUN
admet-42	208	24	-	-	PUNCT
admet-42	208	25	distance	distance	NOUN
admet-42	208	26	profiles	profile	NOUN
admet-42	208	27	of	of	ADP
admet-42	208	28	topically	topically	ADV
admet-42	208	29	applied	apply	VERB
admet-42	208	30	drugs	drug	NOUN
admet-42	208	31	for	for	ADP
admet-42	208	32	comparisons	comparison	NOUN
admet-42	208	33	in	in	ADP
admet-42	208	34	order	order	NOUN
admet-42	208	35	to	to	PART
admet-42	208	36	evaluate	evaluate	VERB
admet-42	208	37	the	the	DET
admet-42	208	38	present	present	ADJ
admet-42	208	39	clsm	clsm	NOUN
admet-42	208	40	technique	technique	NOUN
admet-42	208	41	.	.	PUNCT
admet-42	209	1	a	a	DET
admet-42	209	2	strong	strong	ADJ
admet-42	209	3	correlation	correlation	NOUN
admet-42	209	4	(	(	PUNCT
admet-42	209	5	r2=0.99636	r2=0.99636	NOUN
admet-42	209	6	)	)	PUNCT
admet-42	209	7	was	be	AUX
admet-42	209	8	observed	observe	VERB
admet-42	209	9	between	between	ADP
admet-42	209	10	the	the	DET
admet-42	209	11	intensity	intensity	NOUN
admet-42	209	12	of	of	ADP
admet-42	209	13	fluorescence	fluorescence	NOUN
admet-42	209	14	on	on	ADP
admet-42	209	15	clsm	clsm	NOUN
admet-42	209	16	images	image	NOUN
admet-42	209	17	and	and	CCONJ
admet-42	209	18	the	the	DET
admet-42	209	19	applied	apply	VERB
admet-42	209	20	concentration	concentration	NOUN
admet-42	209	21	of	of	ADP
admet-42	209	22	fd-4	fd-4	PUNCT
admet-42	209	23	(	(	PUNCT
admet-42	209	24	fig	fig	NOUN
admet-42	209	25	.	.	PUNCT
admet-42	210	1	6	6	NUM
admet-42	210	2	)	)	PUNCT
admet-42	210	3	,	,	PUNCT
admet-42	210	4	which	which	PRON
admet-42	210	5	indicated	indicate	VERB
admet-42	210	6	that	that	SCONJ
admet-42	210	7	the	the	DET
admet-42	210	8	intensity	intensity	NOUN
admet-42	210	9	of	of	ADP
admet-42	210	10	fluorescence	fluorescence	NOUN
admet-42	210	11	at	at	ADP
admet-42	210	12	each	each	DET
admet-42	210	13	depth	depth	NOUN
admet-42	210	14	of	of	ADP
admet-42	210	15	the	the	DET
admet-42	210	16	skin	skin	NOUN
admet-42	210	17	could	could	AUX
admet-42	210	18	be	be	AUX
admet-42	210	19	quantitatively	quantitatively	ADV
admet-42	210	20	evaluated	evaluate	VERB
admet-42	210	21	by	by	ADP
admet-42	210	22	clsm	clsm	NOUN
admet-42	210	23	.	.	PUNCT
admet-42	211	1	although	although	SCONJ
admet-42	211	2	few	few	ADJ
admet-42	211	3	studies	study	NOUN
admet-42	211	4	have	have	AUX
admet-42	211	5	determined	determine	VERB
admet-42	211	6	the	the	DET
admet-42	211	7	drug	drug	NOUN
admet-42	211	8	concentration	concentration	NOUN
admet-42	211	9	-	-	PUNCT
admet-42	211	10	distance	distance	NOUN
admet-42	211	11	profiles	profile	NOUN
admet-42	211	12	of	of	ADP
admet-42	211	13	topically	topically	ADV
admet-42	211	14	applied	apply	VERB
admet-42	211	15	drugs	drug	NOUN
admet-42	211	16	,	,	PUNCT
admet-42	211	17	even	even	ADV
admet-42	211	18	less	less	ADJ
admet-42	211	19	attention	attention	NOUN
admet-42	211	20	has	have	AUX
admet-42	211	21	been	be	AUX
admet-42	211	22	given	give	VERB
admet-42	211	23	to	to	ADP
admet-42	211	24	understanding	understand	VERB
admet-42	211	25	the	the	DET
admet-42	211	26	disposition	disposition	NOUN
admet-42	211	27	behavior	behavior	NOUN
admet-42	211	28	of	of	ADP
admet-42	211	29	these	these	DET
admet-42	211	30	drugs	drug	NOUN
admet-42	211	31	through	through	ADP
admet-42	211	32	the	the	DET
admet-42	211	33	skin	skin	NOUN
admet-42	211	34	under	under	ADP
admet-42	211	35	both	both	CCONJ
admet-42	211	36	steady	steady	ADJ
admet-42	211	37	-	-	PUNCT
admet-42	211	38	state	state	NOUN
admet-42	211	39	and	and	CCONJ
admet-42	211	40	non	non	ADJ
admet-42	211	41	-	-	ADJ
admet-42	211	42	steady	steady	ADJ
admet-42	211	43	state	state	NOUN
admet-42	211	44	conditions	condition	NOUN
admet-42	211	45	.	.	PUNCT
admet-42	212	1	therefore	therefore	ADV
admet-42	212	2	,	,	PUNCT
admet-42	212	3	evaluating	evaluate	VERB
admet-42	212	4	skin	skin	NOUN
admet-42	212	5	concentration	concentration	NOUN
admet-42	212	6	-	-	PUNCT
admet-42	212	7	distance	distance	NOUN
admet-42	212	8	profiles	profile	NOUN
admet-42	212	9	is	be	AUX
admet-42	212	10	important	important	ADJ
admet-42	212	11	under	under	ADP
admet-42	212	12	these	these	DET
admet-42	212	13	conditions	condition	NOUN
admet-42	212	14	in	in	ADP
admet-42	212	15	order	order	NOUN
admet-42	212	16	to	to	PART
admet-42	212	17	address	address	VERB
admet-42	212	18	not	not	PART
admet-42	212	19	only	only	ADV
admet-42	212	20	to	to	ADP
admet-42	212	21	efficacy	efficacy	VERB
admet-42	212	22	,	,	PUNCT
admet-42	212	23	but	but	CCONJ
admet-42	212	24	also	also	ADV
admet-42	212	25	toxicological	toxicological	ADJ
admet-42	212	26	issues	issue	NOUN
admet-42	212	27	.	.	PUNCT
admet-42	213	1	sugibayashi	sugibayashi	PROPN
admet-42	213	2	et.al	et.al	PROPN
admet-42	213	3	.	.	PUNCT
admet-42	214	1	admet	admet	PROPN
admet-42	214	2	&	&	CCONJ
admet-42	214	3	dmpk	dmpk	PROPN
admet-42	214	4	2(4	2(4	NUM
admet-42	214	5	)	)	PUNCT
admet-42	214	6	(	(	PUNCT
admet-42	214	7	2014	2014	NUM
admet-42	214	8	)	)	PUNCT
admet-42	214	9	221	221	NUM
admet-42	214	10	-	-	SYM
admet-42	214	11	234	234	NUM
admet-42	214	12	232	232	NUM
admet-42	214	13	x	x	SYM
admet-42	214	14	=	=	SYM
admet-42	214	15	0	0	NUM
admet-42	214	16	200	200	NUM
admet-42	214	17	μm	μm	NOUN
admet-42	214	18	x	x	PUNCT
admet-42	215	1	=	=	PRON
admet-42	215	2	ltot	ltot	VERB
admet-42	215	3	200	200	NUM
admet-42	215	4	μm	μm	NUM
admet-42	215	5	200	200	NUM
admet-42	215	6	μm	μm	NOUN
admet-42	215	7	x	x	PUNCT
admet-42	216	1	=	=	SYM
admet-42	216	2	0	0	PUNCT
admet-42	216	3	x	x	X
admet-42	216	4	=	=	PUNCT
admet-42	216	5	ltot	ltot	ADJ
admet-42	216	6	x	x	X
admet-42	216	7	=	=	SYM
admet-42	216	8	0	0	PUNCT
admet-42	216	9	x	x	SYM
admet-42	216	10	=	=	SYM
admet-42	216	11	ltot	ltot	ADJ
admet-42	216	12	figure	figure	NOUN
admet-42	216	13	10	10	NUM
admet-42	216	14	.	.	PUNCT
admet-42	217	1	clsm	clsm	NOUN
admet-42	217	2	images	image	NOUN
admet-42	217	3	of	of	ADP
admet-42	217	4	fd-4	fd-4	NOUN
admet-42	217	5	fluorescence	fluorescence	NOUN
admet-42	217	6	intensity	intensity	NOUN
admet-42	217	7	in	in	ADP
admet-42	217	8	stripped	strip	VERB
admet-42	217	9	pig	pig	NOUN
admet-42	217	10	ear	ear	VERB
admet-42	217	11	skin	skin	NOUN
admet-42	217	12	in	in	ADP
admet-42	217	13	the	the	DET
admet-42	217	14	steady	steady	ADJ
admet-42	217	15	state	state	NOUN
admet-42	217	16	(	(	PUNCT
admet-42	217	17	5	5	NUM
admet-42	217	18	h	h	NOUN
admet-42	217	19	)	)	PUNCT
admet-42	217	20	after	after	ADP
admet-42	217	21	the	the	DET
admet-42	217	22	permeation	permeation	NOUN
admet-42	217	23	experiment	experiment	NOUN
admet-42	217	24	.	.	PUNCT
admet-42	218	1	a	a	X
admet-42	218	2	)	)	PUNCT
admet-42	218	3	,	,	PUNCT
admet-42	218	4	b	b	NOUN
admet-42	218	5	)	)	PUNCT
admet-42	218	6	and	and	CCONJ
admet-42	218	7	c	c	X
admet-42	218	8	)	)	PUNCT
admet-42	218	9	show	show	VERB
admet-42	218	10	samples	sample	NOUN
admet-42	218	11	a	a	DET
admet-42	218	12	,	,	PUNCT
admet-42	218	13	b	b	PROPN
admet-42	218	14	and	and	CCONJ
admet-42	218	15	c	c	NOUN
admet-42	218	16	,	,	PUNCT
admet-42	218	17	respectively	respectively	ADV
admet-42	218	18	.	.	PUNCT
admet-42	219	1	dashed	dash	VERB
admet-42	219	2	line	line	NOUN
admet-42	219	3	:	:	PUNCT
admet-42	219	4	boundary	boundary	NOUN
admet-42	219	5	of	of	ADP
admet-42	219	6	the	the	DET
admet-42	219	7	skin	skin	NOUN
admet-42	219	8	x	x	X
admet-42	220	1	=	=	SYM
admet-42	220	2	0	0	PUNCT
admet-42	220	3	x	x	X
admet-42	220	4	=	=	PRON
admet-42	220	5	ltot	ltot	VERB
admet-42	220	6	200	200	NUM
admet-42	220	7	μm	μm	NOUN
admet-42	220	8	x	x	PUNCT
admet-42	221	1	=	=	SYM
admet-42	221	2	0	0	PUNCT
admet-42	221	3	x	x	X
admet-42	221	4	=	=	PRON
admet-42	221	5	ltot	ltot	VERB
admet-42	221	6	200	200	NUM
admet-42	221	7	μm	μm	NUM
admet-42	221	8	figure	figure	NOUN
admet-42	221	9	11	11	NUM
admet-42	221	10	.	.	PUNCT
admet-42	222	1	clsm	clsm	NOUN
admet-42	222	2	images	image	NOUN
admet-42	222	3	of	of	ADP
admet-42	222	4	fd-4	fd-4	NOUN
admet-42	222	5	fluorescence	fluorescence	NOUN
admet-42	222	6	intensity	intensity	NOUN
admet-42	222	7	stripped	strip	VERB
admet-42	222	8	pig	pig	NOUN
admet-42	222	9	ear	ear	VERB
admet-42	222	10	skin	skin	NOUN
admet-42	222	11	in	in	ADP
admet-42	222	12	the	the	DET
admet-42	222	13	non	non	ADJ
admet-42	222	14	-	-	ADJ
admet-42	222	15	steady	steady	ADJ
admet-42	222	16	state	state	NOUN
admet-42	222	17	(	(	PUNCT
admet-42	222	18	0.5	0.5	NUM
admet-42	222	19	h	h	NOUN
admet-42	222	20	)	)	PUNCT
admet-42	222	21	after	after	ADP
admet-42	222	22	the	the	DET
admet-42	222	23	permeation	permeation	NOUN
admet-42	222	24	experiment	experiment	NOUN
admet-42	222	25	.	.	PUNCT
admet-42	223	1	a	a	PRON
admet-42	223	2	)	)	PUNCT
admet-42	223	3	and	and	CCONJ
admet-42	223	4	b	b	X
admet-42	223	5	)	)	PUNCT
admet-42	223	6	show	show	VERB
admet-42	223	7	samples	sample	NOUN
admet-42	223	8	a	a	PRON
admet-42	223	9	and	and	CCONJ
admet-42	223	10	b	b	NOUN
admet-42	223	11	,	,	PUNCT
admet-42	223	12	respectively	respectively	ADV
admet-42	223	13	.	.	PUNCT
admet-42	224	1	dashed	dash	VERB
admet-42	224	2	line	line	NOUN
admet-42	224	3	:	:	PUNCT
admet-42	224	4	boundary	boundary	NOUN
admet-42	224	5	of	of	ADP
admet-42	224	6	the	the	DET
admet-42	224	7	skin	skin	NOUN
admet-42	224	8	theoretical	theoretical	ADJ
admet-42	224	9	and	and	CCONJ
admet-42	224	10	observed	observed	ADJ
admet-42	224	11	fd-4	fd-4	NOUN
admet-42	224	12	skin	skin	NOUN
admet-42	224	13	concentration	concentration	NOUN
admet-42	224	14	-	-	PUNCT
admet-42	224	15	distance	distance	NOUN
admet-42	224	16	profiles	profile	NOUN
admet-42	224	17	were	be	AUX
admet-42	224	18	determined	determine	VERB
admet-42	224	19	in	in	ADP
admet-42	224	20	both	both	CCONJ
admet-42	224	21	the	the	DET
admet-42	224	22	steady	steady	ADJ
admet-42	224	23	and	and	CCONJ
admet-42	224	24	non	non	ADJ
admet-42	224	25	-	-	ADJ
admet-42	224	26	steady	steady	ADJ
admet-42	224	27	states	state	NOUN
admet-42	224	28	in	in	ADP
admet-42	224	29	the	the	DET
admet-42	224	30	present	present	ADJ
admet-42	224	31	study	study	NOUN
admet-42	224	32	.	.	PUNCT
admet-42	225	1	the	the	DET
admet-42	225	2	theoretical	theoretical	ADJ
admet-42	225	3	and	and	CCONJ
admet-42	225	4	observed	observed	ADJ
admet-42	225	5	fd-4	fd-4	NOUN
admet-42	225	6	concentration	concentration	NOUN
admet-42	225	7	-	-	PUNCT
admet-42	225	8	distance	distance	NOUN
admet-42	225	9	profiles	profile	NOUN
admet-42	225	10	were	be	AUX
admet-42	225	11	almost	almost	ADV
admet-42	225	12	equal	equal	ADJ
admet-42	225	13	at	at	ADP
admet-42	225	14	the	the	DET
admet-42	225	15	steady	steady	ADJ
admet-42	225	16	and	and	CCONJ
admet-42	225	17	non	non	ADJ
admet-42	225	18	-	-	ADJ
admet-42	225	19	steady	steady	ADJ
admet-42	225	20	states	state	NOUN
admet-42	225	21	(	(	PUNCT
admet-42	225	22	figs	fig	NOUN
admet-42	225	23	.	.	X
admet-42	225	24	8	8	NUM
admet-42	225	25	and	and	CCONJ
admet-42	225	26	9	9	NUM
admet-42	225	27	)	)	PUNCT
admet-42	225	28	,	,	PUNCT
admet-42	225	29	which	which	PRON
admet-42	225	30	suggested	suggest	VERB
admet-42	225	31	that	that	SCONJ
admet-42	225	32	the	the	DET
admet-42	225	33	concentration	concentration	NOUN
admet-42	225	34	of	of	ADP
admet-42	225	35	the	the	DET
admet-42	225	36	fluorescence	fluorescence	NOUN
admet-42	225	37	compound	compound	NOUN
admet-42	225	38	may	may	AUX
admet-42	225	39	be	be	AUX
admet-42	225	40	precisely	precisely	ADV
admet-42	225	41	evaluated	evaluate	VERB
admet-42	225	42	at	at	ADP
admet-42	225	43	multiple	multiple	ADJ
admet-42	225	44	depths	depth	NOUN
admet-42	225	45	through	through	ADP
admet-42	225	46	skin	skin	NOUN
admet-42	225	47	using	use	VERB
admet-42	225	48	clsm	clsm	NOUN
admet-42	225	49	.	.	PUNCT
admet-42	226	1	common	common	ADJ
admet-42	226	2	artifacts	artifact	NOUN
admet-42	226	3	include	include	VERB
admet-42	226	4	tearing	tear	VERB
admet-42	226	5	,	,	PUNCT
admet-42	226	6	ripping	ripping	NOUN
admet-42	226	7	,	,	PUNCT
admet-42	226	8	holes	hole	NOUN
admet-42	226	9	,	,	PUNCT
admet-42	226	10	and	and	CCONJ
admet-42	226	11	folding	folding	NOUN
admet-42	226	12	may	may	AUX
admet-42	226	13	occur	occur	VERB
admet-42	226	14	during	during	ADP
admet-42	226	15	skin	skin	NOUN
admet-42	226	16	sectioning	sectioning	NOUN
admet-42	226	17	;	;	PUNCT
admet-42	226	18	stratum	stratum	PROPN
admet-42	226	19	corneum	corneum	VERB
admet-42	226	20	side	side	PROPN
admet-42	226	21	dermis	dermis	PROPN
admet-42	226	22	side	side	PROPN
admet-42	226	23	a	a	PRON
admet-42	226	24	)	)	PUNCT
admet-42	226	25	b	b	NOUN
admet-42	226	26	)	)	PUNCT
admet-42	226	27	c	c	NOUN
admet-42	226	28	)	)	PUNCT
admet-42	226	29	stratum	stratum	PROPN
admet-42	226	30	corneum	corneum	VERB
admet-42	226	31	side	side	NOUN
admet-42	226	32	dermis	dermis	NOUN
admet-42	226	33	side	side	NOUN
admet-42	226	34	x	x	PUNCT
admet-42	227	1	=	=	NOUN
admet-42	227	2	0	0	PUNCT
admet-42	227	3	x	x	SYM
admet-42	227	4	=	=	NOUN
admet-42	227	5	0	0	PUNCT
admet-42	227	6	x	x	X
admet-42	227	7	=	=	PUNCT
admet-42	227	8	ltot	ltot	ADJ
admet-42	227	9	x	x	X
admet-42	227	10	=	=	SYM
admet-42	227	11	ltot	ltot	ADJ
admet-42	227	12	admet	admet	PROPN
admet-42	227	13	&	&	CCONJ
admet-42	227	14	dmpk	dmpk	PROPN
admet-42	227	15	2(4	2(4	NUM
admet-42	227	16	)	)	PUNCT
admet-42	227	17	(	(	PUNCT
admet-42	227	18	2014	2014	NUM
admet-42	227	19	)	)	PUNCT
admet-42	227	20	221	221	NUM
admet-42	227	21	-	-	SYM
admet-42	227	22	234	234	NUM
admet-42	227	23	imaging	imaging	NOUN
admet-42	227	24	analysis	analysis	NOUN
admet-42	227	25	of	of	ADP
admet-42	227	26	topically	topically	ADV
admet-42	227	27	applied	apply	VERB
admet-42	227	28	fitc	fitc	NOUN
admet-42	227	29	-	-	PUNCT
admet-42	227	30	dextran	dextran	VERB
admet-42	227	31	doi	doi	NOUN
admet-42	227	32	:	:	PUNCT
admet-42	227	33	10.5599	10.5599	NUM
admet-42	227	34	/	/	SYM
admet-42	227	35	admet.2.4.42	admet.2.4.42	PRON
admet-42	227	36	233	233	NUM
admet-42	227	37	therefore	therefore	ADV
admet-42	227	38	,	,	PUNCT
admet-42	227	39	analysis	analysis	NOUN
admet-42	227	40	points	point	NOUN
admet-42	227	41	must	must	AUX
admet-42	227	42	be	be	AUX
admet-42	227	43	plotted	plot	VERB
admet-42	227	44	to	to	PART
admet-42	227	45	avoid	avoid	VERB
admet-42	227	46	such	such	ADJ
admet-42	227	47	artifacts	artifact	NOUN
admet-42	227	48	in	in	ADP
admet-42	227	49	order	order	NOUN
admet-42	227	50	to	to	PART
admet-42	227	51	calculate	calculate	VERB
admet-42	227	52	the	the	DET
admet-42	227	53	fluorescent	fluorescent	ADJ
admet-42	227	54	intensity	intensity	NOUN
admet-42	227	55	for	for	ADP
admet-42	227	56	fd-4	fd-4	NUM
admet-42	227	57	from	from	ADP
admet-42	227	58	one	one	NUM
admet-42	227	59	skin	skin	NOUN
admet-42	227	60	section	section	NOUN
admet-42	227	61	(	(	PUNCT
admet-42	227	62	fig	fig	NOUN
admet-42	227	63	.	.	PUNCT
admet-42	228	1	3	3	NUM
admet-42	228	2	)	)	PUNCT
admet-42	228	3	.	.	PUNCT
admet-42	229	1	this	this	PRON
admet-42	229	2	could	could	AUX
admet-42	229	3	explain	explain	VERB
admet-42	229	4	why	why	SCONJ
admet-42	229	5	slightly	slightly	ADV
admet-42	229	6	different	different	ADJ
admet-42	229	7	skin	skin	NOUN
admet-42	229	8	concentrationdistance	concentrationdistance	NOUN
admet-42	229	9	values	value	NOUN
admet-42	229	10	were	be	AUX
admet-42	229	11	obtained	obtain	VERB
admet-42	229	12	for	for	ADP
admet-42	229	13	fd-4	fd-4	NUM
admet-42	229	14	between	between	ADP
admet-42	229	15	clsm	clsm	NOUN
admet-42	229	16	and	and	CCONJ
admet-42	229	17	the	the	DET
admet-42	229	18	theoretical	theoretical	ADJ
admet-42	229	19	values	value	NOUN
admet-42	229	20	(	(	PUNCT
admet-42	229	21	figs	fig	NOUN
admet-42	229	22	.	.	X
admet-42	229	23	8	8	NUM
admet-42	229	24	and	and	CCONJ
admet-42	229	25	9	9	NUM
admet-42	229	26	)	)	PUNCT
admet-42	229	27	.	.	PUNCT
admet-42	230	1	furthermore	furthermore	ADV
admet-42	230	2	,	,	PUNCT
admet-42	230	3	plotted	plot	VERB
admet-42	230	4	analysis	analysis	NOUN
admet-42	230	5	points	point	NOUN
admet-42	230	6	(	(	PUNCT
admet-42	230	7	25	25	NUM
admet-42	230	8	,	,	PUNCT
admet-42	230	9	31	31	NUM
admet-42	230	10	,	,	PUNCT
admet-42	230	11	37	37	NUM
admet-42	230	12	and	and	CCONJ
admet-42	230	13	43	43	NUM
admet-42	230	14	)	)	PUNCT
admet-42	230	15	(	(	PUNCT
admet-42	230	16	fig	fig	NOUN
admet-42	230	17	.	.	PUNCT
admet-42	231	1	3	3	X
admet-42	231	2	)	)	PUNCT
admet-42	231	3	were	be	AUX
admet-42	231	4	not	not	PART
admet-42	231	5	selected	select	VERB
admet-42	231	6	as	as	ADP
admet-42	231	7	reference	reference	NOUN
admet-42	231	8	points	point	NOUN
admet-42	231	9	to	to	PART
admet-42	231	10	determine	determine	VERB
admet-42	231	11	skin	skin	NOUN
admet-42	231	12	concentration	concentration	NOUN
admet-42	231	13	-	-	PUNCT
admet-42	231	14	distance	distance	NOUN
admet-42	231	15	profiles	profile	NOUN
admet-42	231	16	due	due	ADP
admet-42	231	17	to	to	ADP
admet-42	231	18	the	the	DET
admet-42	231	19	high	high	ADJ
admet-42	231	20	intensity	intensity	NOUN
admet-42	231	21	of	of	ADP
admet-42	231	22	fd-4	fd-4	NOUN
admet-42	231	23	at	at	ADP
admet-42	231	24	the	the	DET
admet-42	231	25	epidermis	epidermis	NOUN
admet-42	231	26	side	side	NOUN
admet-42	231	27	.	.	PUNCT
admet-42	232	1	plotted	plot	VERB
admet-42	232	2	analysis	analysis	NOUN
admet-42	232	3	points	point	NOUN
admet-42	232	4	(	(	PUNCT
admet-42	232	5	30	30	NUM
admet-42	232	6	,	,	PUNCT
admet-42	232	7	36	36	NUM
admet-42	232	8	,	,	PUNCT
admet-42	232	9	42	42	NUM
admet-42	232	10	and	and	CCONJ
admet-42	232	11	48	48	NUM
admet-42	232	12	)	)	PUNCT
admet-42	232	13	(	(	PUNCT
admet-42	232	14	fig	fig	NOUN
admet-42	232	15	.	.	PUNCT
admet-42	233	1	3	3	NUM
admet-42	233	2	)	)	PUNCT
admet-42	233	3	at	at	ADP
admet-42	233	4	the	the	DET
admet-42	233	5	dermis	dermis	NOUN
admet-42	233	6	side	side	NOUN
admet-42	233	7	were	be	AUX
admet-42	233	8	also	also	ADV
admet-42	233	9	not	not	PART
admet-42	233	10	selected	select	VERB
admet-42	233	11	as	as	ADP
admet-42	233	12	reference	reference	NOUN
admet-42	233	13	points	point	NOUN
admet-42	233	14	to	to	PART
admet-42	233	15	determine	determine	VERB
admet-42	233	16	skin	skin	NOUN
admet-42	233	17	concentration	concentration	NOUN
admet-42	233	18	-	-	PUNCT
admet-42	233	19	distance	distance	NOUN
admet-42	233	20	profiles	profile	NOUN
admet-42	233	21	because	because	SCONJ
admet-42	233	22	they	they	PRON
admet-42	233	23	overlapped	overlap	VERB
admet-42	233	24	with	with	ADP
admet-42	233	25	the	the	DET
admet-42	233	26	receiver	receiver	ADJ
admet-42	233	27	compartment	compartment	NOUN
admet-42	233	28	,	,	PUNCT
admet-42	233	29	which	which	PRON
admet-42	233	30	may	may	AUX
admet-42	233	31	lead	lead	VERB
admet-42	233	32	to	to	ADP
admet-42	233	33	unclear	unclear	ADJ
admet-42	233	34	images	image	NOUN
admet-42	233	35	by	by	ADP
admet-42	233	36	clsm	clsm	NOUN
admet-42	233	37	.	.	PUNCT
admet-42	234	1	the	the	DET
admet-42	234	2	present	present	ADJ
admet-42	234	3	clsm	clsm	NOUN
admet-42	234	4	method	method	NOUN
admet-42	234	5	provided	provide	VERB
admet-42	234	6	a	a	DET
admet-42	234	7	visual	visual	ADJ
admet-42	234	8	observation	observation	NOUN
admet-42	234	9	of	of	ADP
admet-42	234	10	drug	drug	NOUN
admet-42	234	11	distribution	distribution	NOUN
admet-42	234	12	at	at	ADP
admet-42	234	13	multiple	multiple	ADJ
admet-42	234	14	depths	depth	NOUN
admet-42	234	15	through	through	ADP
admet-42	234	16	the	the	DET
admet-42	234	17	skin	skin	NOUN
admet-42	234	18	(	(	PUNCT
admet-42	234	19	figs	fig	NOUN
admet-42	234	20	.	.	PUNCT
admet-42	235	1	10	10	NUM
admet-42	235	2	and	and	CCONJ
admet-42	235	3	11	11	NUM
admet-42	235	4	)	)	PUNCT
admet-42	235	5	as	as	ADP
admet-42	235	6	an	an	DET
admet-42	235	7	additional	additional	ADJ
admet-42	235	8	advantage	advantage	NOUN
admet-42	235	9	over	over	ADP
admet-42	235	10	the	the	DET
admet-42	235	11	mathematical	mathematical	ADJ
admet-42	235	12	approach	approach	NOUN
admet-42	235	13	.	.	PUNCT
admet-42	236	1	however	however	ADV
admet-42	236	2	,	,	PUNCT
admet-42	236	3	the	the	DET
admet-42	236	4	intensity	intensity	NOUN
admet-42	236	5	of	of	ADP
admet-42	236	6	fluorescence	fluorescence	NOUN
admet-42	236	7	intensity	intensity	NOUN
admet-42	236	8	was	be	AUX
admet-42	236	9	markedly	markedly	ADV
admet-42	236	10	high	high	ADJ
admet-42	236	11	on	on	ADP
admet-42	236	12	the	the	DET
admet-42	236	13	epidermis	epidermis	NOUN
admet-42	236	14	surface	surface	NOUN
admet-42	236	15	.	.	PUNCT
admet-42	237	1	thus	thus	ADV
admet-42	237	2	,	,	PUNCT
admet-42	237	3	it	it	PRON
admet-42	237	4	is	be	AUX
admet-42	237	5	necessary	necessary	ADJ
admet-42	237	6	to	to	PART
admet-42	237	7	carefully	carefully	ADV
admet-42	237	8	wash	wash	VERB
admet-42	237	9	the	the	DET
admet-42	237	10	fluorescence	fluorescence	NOUN
admet-42	237	11	compound	compound	NOUN
admet-42	237	12	that	that	PRON
admet-42	237	13	is	be	AUX
admet-42	237	14	adsorbed	adsorb	VERB
admet-42	237	15	on	on	ADP
admet-42	237	16	the	the	DET
admet-42	237	17	skin	skin	NOUN
admet-42	237	18	surface	surface	NOUN
admet-42	237	19	.	.	PUNCT
admet-42	238	1	further	further	ADJ
admet-42	238	2	studies	study	NOUN
admet-42	238	3	are	be	AUX
admet-42	238	4	needed	need	VERB
admet-42	238	5	to	to	PART
admet-42	238	6	evaluate	evaluate	VERB
admet-42	238	7	the	the	DET
admet-42	238	8	distribution	distribution	NOUN
admet-42	238	9	of	of	ADP
admet-42	238	10	fd-4	fd-4	NOUN
admet-42	238	11	in	in	ADP
admet-42	238	12	skin	skin	NOUN
admet-42	238	13	sections	section	NOUN
admet-42	238	14	cut	cut	VERB
admet-42	238	15	laterally	laterally	ADV
admet-42	238	16	as	as	ADV
admet-42	238	17	well	well	ADV
admet-42	238	18	as	as	ADP
admet-42	238	19	through	through	ADP
admet-42	238	20	skin	skin	NOUN
admet-42	238	21	appendages	appendage	NOUN
admet-42	238	22	such	such	ADJ
admet-42	238	23	as	as	ADP
admet-42	238	24	hair	hair	NOUN
admet-42	238	25	follicles	follicle	NOUN
admet-42	238	26	.	.	PUNCT
admet-42	239	1	we	we	PRON
admet-42	239	2	intend	intend	VERB
admet-42	239	3	to	to	PART
admet-42	239	4	use	use	VERB
admet-42	239	5	low	low	ADJ
admet-42	239	6	molecular	molecular	ADJ
admet-42	239	7	-	-	PUNCT
admet-42	239	8	weight	weight	NOUN
admet-42	239	9	fluorescence	fluorescence	NOUN
admet-42	239	10	compounds	compound	VERB
admet-42	239	11	in	in	ADP
admet-42	239	12	future	future	ADJ
admet-42	239	13	studies	study	NOUN
admet-42	239	14	.	.	PUNCT
admet-42	240	1	conclusions	conclusion	NOUN
admet-42	240	2	the	the	DET
admet-42	240	3	results	result	NOUN
admet-42	240	4	of	of	ADP
admet-42	240	5	the	the	DET
admet-42	240	6	present	present	ADJ
admet-42	240	7	study	study	NOUN
admet-42	240	8	clearly	clearly	ADV
admet-42	240	9	demonstrated	demonstrate	VERB
admet-42	240	10	that	that	SCONJ
admet-42	240	11	clsm	clsm	NOUN
admet-42	240	12	may	may	AUX
admet-42	240	13	be	be	AUX
admet-42	240	14	used	use	VERB
admet-42	240	15	to	to	PART
admet-42	240	16	quantitatively	quantitatively	ADV
admet-42	240	17	determine	determine	VERB
admet-42	240	18	the	the	DET
admet-42	240	19	concentration	concentration	NOUN
admet-42	240	20	-	-	PUNCT
admet-42	240	21	distance	distance	NOUN
admet-42	240	22	profiles	profile	NOUN
admet-42	240	23	of	of	ADP
admet-42	240	24	topically	topically	ADV
admet-42	240	25	applied	apply	VERB
admet-42	240	26	fluorescent	fluorescent	ADJ
admet-42	240	27	drugs	drug	NOUN
admet-42	240	28	.	.	PUNCT
admet-42	241	1	these	these	DET
admet-42	241	2	results	result	NOUN
admet-42	241	3	provide	provide	VERB
admet-42	241	4	a	a	DET
admet-42	241	5	useful	useful	ADJ
admet-42	241	6	insight	insight	NOUN
admet-42	241	7	into	into	ADP
admet-42	241	8	dermatopharmacokinetics	dermatopharmacokinetic	NOUN
admet-42	241	9	.	.	PUNCT
admet-42	242	1	references	reference	NOUN
admet-42	242	2	[	[	X
admet-42	242	3	1	1	NUM
admet-42	242	4	]	]	PUNCT
admet-42	242	5	a.	a.	PROPN
admet-42	242	6	naik	naik	PROPN
admet-42	242	7	,	,	PUNCT
admet-42	242	8	y.n	y.n	PROPN
admet-42	242	9	.	.	PROPN
admet-42	242	10	kalia	kalia	PROPN
admet-42	242	11	,	,	PUNCT
admet-42	242	12	r.h	r.h	PROPN
admet-42	242	13	.	.	PROPN
admet-42	242	14	guy	guy	NOUN
admet-42	242	15	,	,	PUNCT
admet-42	242	16	pharm	pharm	PROPN
admet-42	242	17	.	.	PUNCT
admet-42	243	1	sci	sci	PROPN
admet-42	243	2	.	.	PROPN
admet-42	243	3	technol	technol	PROPN
admet-42	243	4	.	.	PUNCT
admet-42	244	1	today	today	NOUN
admet-42	244	2	3	3	NUM
admet-42	244	3	(	(	PUNCT
admet-42	244	4	2001	2001	NUM
admet-42	244	5	)	)	PUNCT
admet-42	244	6	318	318	NUM
admet-42	244	7	-	-	SYM
admet-42	244	8	326	326	NUM
admet-42	244	9	.	.	PUNCT
admet-42	245	1	[	[	X
admet-42	245	2	2	2	X
admet-42	245	3	]	]	X
admet-42	245	4	h.	h.	PROPN
admet-42	245	5	wosicka	wosicka	PROPN
admet-42	245	6	,	,	PUNCT
admet-42	245	7	k.	k.	PROPN
admet-42	245	8	cal	cal	PROPN
admet-42	245	9	,	,	PUNCT
admet-42	245	10	j.	j.	PROPN
admet-42	245	11	dermatol	dermatol	PROPN
admet-42	245	12	.	.	PUNCT
admet-42	246	1	sci	sci	PROPN
admet-42	246	2	.	.	PROPN
admet-42	247	1	57	57	NUM
admet-42	247	2	(	(	PUNCT
admet-42	247	3	2011	2011	NUM
admet-42	247	4	)	)	PUNCT
admet-42	247	5	83	83	NUM
admet-42	247	6	-	-	SYM
admet-42	247	7	89	89	NUM
admet-42	247	8	.	.	PUNCT
admet-42	248	1	[	[	X
admet-42	248	2	3	3	X
admet-42	248	3	]	]	X
admet-42	248	4	m.r	m.r	PROPN
admet-42	248	5	.	.	PROPN
admet-42	248	6	prausnitz	prausnitz	PROPN
admet-42	248	7	,	,	PUNCT
admet-42	248	8	s.	s.	PROPN
admet-42	248	9	mitragotri	mitragotri	PROPN
admet-42	248	10	,	,	PUNCT
admet-42	248	11	r.	r.	PROPN
admet-42	248	12	langer	langer	PROPN
admet-42	248	13	,	,	PUNCT
admet-42	248	14	drug	drug	NOUN
admet-42	248	15	discovery	discovery	NOUN
admet-42	248	16	3	3	NUM
admet-42	248	17	(	(	PUNCT
admet-42	248	18	2004	2004	NUM
admet-42	248	19	)	)	PUNCT
admet-42	248	20	115	115	NUM
admet-42	248	21	-	-	SYM
admet-42	248	22	124	124	NUM
admet-42	248	23	.	.	PUNCT
admet-42	249	1	[	[	X
admet-42	249	2	4	4	X
admet-42	249	3	]	]	X
admet-42	249	4	t.	t.	PROPN
admet-42	249	5	oshizaka	oshizaka	PROPN
admet-42	249	6	,	,	PUNCT
admet-42	249	7	h.	h.	PROPN
admet-42	249	8	todo	todo	PROPN
admet-42	249	9	,	,	PUNCT
admet-42	249	10	k.	k.	PROPN
admet-42	249	11	sugibayashi	sugibayashi	PROPN
admet-42	249	12	,	,	PUNCT
admet-42	249	13	yakugaku	yakugaku	PROPN
admet-42	249	14	zasshi	zasshi	PROPN
admet-42	249	15	132	132	NUM
admet-42	249	16	(	(	PUNCT
admet-42	249	17	2012	2012	NUM
admet-42	249	18	)	)	PUNCT
admet-42	249	19	1237	1237	NUM
admet-42	249	20	-	-	SYM
admet-42	249	21	1243	1243	NUM
admet-42	249	22	.	.	PUNCT
admet-42	250	1	[	[	X
admet-42	250	2	5	5	X
admet-42	250	3	]	]	X
admet-42	250	4	g.	g.	PROPN
admet-42	250	5	cevc	cevc	PROPN
admet-42	250	6	,	,	PUNCT
admet-42	250	7	u.	u.	PROPN
admet-42	250	8	vierl	vierl	PROPN
admet-42	250	9	,	,	PUNCT
admet-42	250	10	j.	j.	PROPN
admet-42	250	11	control	control	PROPN
admet-42	250	12	.	.	PUNCT
admet-42	251	1	release	release	VERB
admet-42	251	2	141	141	NUM
admet-42	251	3	(	(	PUNCT
admet-42	251	4	2010	2010	NUM
admet-42	251	5	)	)	PUNCT
admet-42	251	6	277	277	NUM
admet-42	251	7	-	-	SYM
admet-42	251	8	299	299	NUM
admet-42	251	9	.	.	PUNCT
admet-42	252	1	[	[	X
admet-42	252	2	6	6	NUM
admet-42	252	3	]	]	PUNCT
admet-42	252	4	o.	o.	NOUN
admet-42	252	5	sarheed	sarheed	NOUN
admet-42	252	6	,	,	PUNCT
admet-42	252	7	y.	y.	PROPN
admet-42	252	8	frum	frum	PROPN
admet-42	252	9	,	,	PUNCT
admet-42	252	10	int	int	NOUN
admet-42	252	11	.	.	PUNCT
admet-42	253	1	j.	j.	PROPN
admet-42	253	2	pharm	pharm	PROPN
admet-42	253	3	.	.	PUNCT
admet-42	254	1	423	423	NUM
admet-42	254	2	(	(	PUNCT
admet-42	254	3	2012	2012	NUM
admet-42	254	4	)	)	PUNCT
admet-42	254	5	179	179	NUM
admet-42	254	6	-	-	SYM
admet-42	254	7	183	183	NUM
admet-42	254	8	.	.	PUNCT
admet-42	255	1	[	[	X
admet-42	255	2	7	7	X
admet-42	255	3	]	]	X
admet-42	255	4	m.	m.	NOUN
admet-42	255	5	tsang	tsang	PROPN
admet-42	255	6	,	,	PUNCT
admet-42	255	7	r.h	r.h	PROPN
admet-42	255	8	.	.	PROPN
admet-42	255	9	guy	guy	NOUN
admet-42	255	10	,	,	PUNCT
admet-42	255	11	br	br	PROPN
admet-42	255	12	.	.	PUNCT
admet-42	256	1	j.	j.	PROPN
admet-42	256	2	dermatol	dermatol	PROPN
admet-42	256	3	.	.	PUNCT
admet-42	257	1	165	165	NUM
admet-42	257	2	(	(	PUNCT
admet-42	257	3	2010	2010	NUM
admet-42	257	4	)	)	PUNCT
admet-42	257	5	954	954	NUM
admet-42	257	6	-	-	SYM
admet-42	257	7	958	958	NUM
admet-42	257	8	.	.	PUNCT
admet-42	258	1	[	[	X
admet-42	258	2	8	8	NUM
admet-42	258	3	]	]	X
admet-42	258	4	u.	u.	PROPN
admet-42	258	5	kiistala	kiistala	PROPN
admet-42	258	6	,	,	PUNCT
admet-42	258	7	j.	j.	PROPN
admet-42	258	8	invest	invest	PROPN
admet-42	258	9	.	.	PUNCT
admet-42	259	1	dermatol	dermatol	NOUN
admet-42	259	2	.	.	PUNCT
admet-42	260	1	50	50	NUM
admet-42	260	2	(	(	PUNCT
admet-42	260	3	1968	1968	NUM
admet-42	260	4	)	)	PUNCT
admet-42	260	5	129	129	NUM
admet-42	260	6	-	-	SYM
admet-42	260	7	137	137	NUM
admet-42	260	8	.	.	PUNCT
admet-42	261	1	[	[	X
admet-42	261	2	9	9	NUM
admet-42	261	3	]	]	PUNCT
admet-42	261	4	c.	c.	PROPN
admet-42	261	5	surber	surber	PROPN
admet-42	261	6	,	,	PUNCT
admet-42	261	7	k.p	k.p	PROPN
admet-42	261	8	.	.	PROPN
admet-42	261	9	wilhelm	wilhelm	PROPN
admet-42	261	10	,	,	PUNCT
admet-42	261	11	d.	d.	PROPN
admet-42	261	12	bermann	bermann	PROPN
admet-42	261	13	,	,	PUNCT
admet-42	261	14	h.i	h.i	PROPN
admet-42	261	15	.	.	PROPN
admet-42	261	16	maibach	maibach	PROPN
admet-42	261	17	,	,	PUNCT
admet-42	261	18	pharm	pharm	PROPN
admet-42	261	19	.	.	PUNCT
admet-42	262	1	res	re	NOUN
admet-42	262	2	.	.	PROPN
admet-42	263	1	10	10	NUM
admet-42	263	2	(	(	PUNCT
admet-42	263	3	1993	1993	NUM
admet-42	263	4	)	)	PUNCT
admet-42	263	5	1291	1291	NUM
admet-42	263	6	-	-	SYM
admet-42	263	7	1294	1294	NUM
admet-42	263	8	.	.	PUNCT
admet-42	264	1	[	[	X
admet-42	264	2	10	10	NUM
admet-42	264	3	]	]	X
admet-42	264	4	l.k	l.k	PROPN
admet-42	264	5	.	.	PROPN
admet-42	264	6	pershing	pershing	PROPN
admet-42	264	7	,	,	PUNCT
admet-42	264	8	b.s	b.s	PROPN
admet-42	264	9	.	.	PROPN
admet-42	264	10	silver	silver	PROPN
admet-42	264	11	,	,	PUNCT
admet-42	264	12	g.g	g.g	PROPN
admet-42	264	13	.	.	PUNCT
admet-42	264	14	krueger	krueger	PROPN
admet-42	264	15	,	,	PUNCT
admet-42	264	16	v.p	v.p	PROPN
admet-42	264	17	.	.	PROPN
admet-42	264	18	shah	shah	PROPN
admet-42	264	19	,	,	PUNCT
admet-42	264	20	j.p	j.p	PROPN
admet-42	264	21	.	.	PROPN
admet-42	264	22	skelley	skelley	PROPN
admet-42	264	23	,	,	PUNCT
admet-42	264	24	pharm	pharm	PROPN
admet-42	264	25	.	.	PUNCT
admet-42	265	1	res	re	NOUN
admet-42	265	2	.	.	PROPN
admet-42	265	3	9	9	NUM
admet-42	265	4	(	(	PUNCT
admet-42	265	5	1992	1992	NUM
admet-42	265	6	)	)	PUNCT
admet-42	265	7	45	45	NUM
admet-42	265	8	-	-	SYM
admet-42	265	9	51	51	NUM
admet-42	265	10	.	.	PUNCT
admet-42	266	1	[	[	X
admet-42	266	2	11	11	NUM
admet-42	266	3	]	]	PUNCT
admet-42	266	4	a.	a.	NOUN
admet-42	266	5	rougier	rougier	NOUN
admet-42	266	6	,	,	PUNCT
admet-42	266	7	d.	d.	PROPN
admet-42	266	8	dupuis	dupuis	PROPN
admet-42	266	9	,	,	PUNCT
admet-42	266	10	c.	c.	PROPN
admet-42	266	11	lotte	lotte	PROPN
admet-42	266	12	,	,	PUNCT
admet-42	266	13	r.	r.	PROPN
admet-42	266	14	roguet	roguet	PROPN
admet-42	266	15	,	,	PUNCT
admet-42	266	16	h.	h.	PROPN
admet-42	266	17	schaefer	schaefer	PROPN
admet-42	266	18	,	,	PUNCT
admet-42	266	19	j.	j.	PROPN
admet-42	266	20	invest	invest	PROPN
admet-42	266	21	.	.	PUNCT
admet-42	267	1	dermatol	dermatol	NOUN
admet-42	267	2	.	.	PUNCT
admet-42	268	1	81	81	NUM
admet-42	268	2	(	(	PUNCT
admet-42	268	3	1983	1983	NUM
admet-42	268	4	)	)	PUNCT
admet-42	268	5	275	275	NUM
admet-42	268	6	-	-	SYM
admet-42	268	7	278	278	NUM
admet-42	268	8	.	.	PUNCT
admet-42	269	1	[	[	X
admet-42	269	2	12	12	NUM
admet-42	269	3	]	]	X
admet-42	269	4	v.p	v.p	PROPN
admet-42	269	5	.	.	PROPN
admet-42	269	6	shah	shah	PROPN
admet-42	269	7	,	,	PUNCT
admet-42	269	8	g.l	g.l	PROPN
admet-42	269	9	.	.	PROPN
admet-42	269	10	flynn	flynn	PROPN
admet-42	269	11	,	,	PUNCT
admet-42	269	12	a.	a.	PROPN
admet-42	269	13	yacobi	yacobi	PROPN
admet-42	269	14	,	,	PUNCT
admet-42	269	15	h.i	h.i	PROPN
admet-42	269	16	.	.	PROPN
admet-42	269	17	maibach	maibach	PROPN
admet-42	269	18	,	,	PUNCT
admet-42	269	19	c.	c.	PROPN
admet-42	269	20	bon	bon	PROPN
admet-42	269	21	,	,	PUNCT
admet-42	269	22	n.m	n.m	PROPN
admet-42	269	23	.	.	PROPN
admet-42	269	24	fleischer	fleischer	PROPN
admet-42	269	25	,	,	PUNCT
admet-42	269	26	t.j	t.j	PROPN
admet-42	269	27	.	.	PROPN
admet-42	269	28	franz	franz	PROPN
admet-42	269	29	,	,	PUNCT
admet-42	269	30	s.a	s.a	PROPN
admet-42	269	31	.	.	PROPN
admet-42	269	32	kaplan	kaplan	PROPN
admet-42	269	33	,	,	PUNCT
admet-42	269	34	j.	j.	PROPN
admet-42	269	35	kawamoto	kawamoto	PROPN
admet-42	269	36	,	,	PUNCT
admet-42	269	37	l.j	l.j	PROPN
admet-42	269	38	.	.	PROPN
admet-42	269	39	lesko	lesko	PROPN
admet-42	269	40	,	,	PUNCT
admet-42	269	41	j.p	j.p	PROPN
admet-42	269	42	.	.	PROPN
admet-42	269	43	marty	marty	PROPN
admet-42	269	44	,	,	PUNCT
admet-42	269	45	l.k	l.k	PROPN
admet-42	269	46	.	.	PROPN
admet-42	269	47	pershing	pershing	PROPN
admet-42	269	48	,	,	PUNCT
admet-42	269	49	h.	h.	PROPN
admet-42	269	50	schaefer	schaefer	PROPN
admet-42	269	51	,	,	PUNCT
admet-42	269	52	j.a	j.a	PROPN
admet-42	269	53	.	.	PROPN
admet-42	269	54	sequeira	sequeira	PROPN
admet-42	269	55	,	,	PUNCT
admet-42	269	56	s.p	s.p	PROPN
admet-42	269	57	.	.	PROPN
admet-42	269	58	shrivastava	shrivastava	PROPN
admet-42	269	59	,	,	PUNCT
admet-42	269	60	j.	j.	PROPN
admet-42	269	61	wilkin	wilkin	PROPN
admet-42	269	62	,	,	PUNCT
admet-42	269	63	r.l	r.l	PROPN
admet-42	269	64	.	.	PROPN
admet-42	269	65	williams	williams	PROPN
admet-42	269	66	,	,	PUNCT
admet-42	269	67	pharm	pharm	PROPN
admet-42	269	68	.	.	PUNCT
admet-42	270	1	res	re	NOUN
admet-42	270	2	.	.	PROPN
admet-42	271	1	15	15	NUM
admet-42	271	2	(	(	PUNCT
admet-42	271	3	1998	1998	NUM
admet-42	271	4	)	)	PUNCT
admet-42	271	5	167	167	NUM
admet-42	271	6	-	-	SYM
admet-42	271	7	171	171	NUM
admet-42	271	8	.	.	PUNCT
admet-42	272	1	[	[	X
admet-42	272	2	13	13	NUM
admet-42	272	3	]	]	PUNCT
admet-42	272	4	m.	m.	NOUN
admet-42	272	5	lodén	lodén	PROPN
admet-42	272	6	,	,	PUNCT
admet-42	272	7	l.	l.	PROPN
admet-42	272	8	ungerth	ungerth	PROPN
admet-42	272	9	,	,	PUNCT
admet-42	272	10	j.	j.	PROPN
admet-42	272	11	serup	serup	PROPN
admet-42	272	12	,	,	PUNCT
admet-42	272	13	acta	acta	PROPN
admet-42	272	14	derm	derm	PROPN
admet-42	272	15	.	.	PUNCT
admet-42	272	16	venereol	venereol	PROPN
admet-42	272	17	.	.	PUNCT
admet-42	273	1	87	87	NUM
admet-42	273	2	(	(	PUNCT
admet-42	273	3	2007	2007	NUM
admet-42	273	4	)	)	PUNCT
admet-42	273	5	485	485	NUM
admet-42	273	6	-	-	SYM
admet-42	273	7	492	492	NUM
admet-42	273	8	.	.	PUNCT
admet-42	274	1	[	[	X
admet-42	274	2	14	14	NUM
admet-42	274	3	]	]	PUNCT
admet-42	274	4	b.	b.	PROPN
admet-42	274	5	n'dri	n'dri	PROPN
admet-42	274	6	-	-	PUNCT
admet-42	274	7	stempfer	stempfer	NOUN
admet-42	274	8	,	,	PUNCT
admet-42	274	9	w.c	w.c	PROPN
admet-42	274	10	.	.	PROPN
admet-42	274	11	navidi	navidi	PROPN
admet-42	274	12	,	,	PUNCT
admet-42	274	13	r.h	r.h	PROPN
admet-42	274	14	.	.	PROPN
admet-42	274	15	guy	guy	NOUN
admet-42	274	16	,	,	PUNCT
admet-42	274	17	a.l	a.l	PROPN
admet-42	274	18	.	.	PROPN
admet-42	274	19	bunge	bunge	PROPN
admet-42	274	20	,	,	PUNCT
admet-42	274	21	pharm	pharm	PROPN
admet-42	274	22	.	.	PUNCT
admet-42	275	1	res	re	NOUN
admet-42	275	2	.	.	PROPN
admet-42	276	1	26	26	NUM
admet-42	276	2	(	(	PUNCT
admet-42	276	3	2009	2009	NUM
admet-42	276	4	)	)	PUNCT
admet-42	276	5	316	316	NUM
admet-42	276	6	-	-	SYM
admet-42	276	7	328	328	NUM
admet-42	276	8	.	.	PUNCT
admet-42	277	1	[	[	X
admet-42	277	2	15	15	NUM
admet-42	277	3	]	]	X
admet-42	277	4	j.e	j.e	PROPN
admet-42	277	5	.	.	PROPN
admet-42	277	6	rim	rim	PROPN
admet-42	277	7	,	,	PUNCT
admet-42	277	8	p.m.	p.m.	NOUN
admet-42	277	9	pinsky	pinsky	PROPN
admet-42	277	10	,	,	PUNCT
admet-42	277	11	w.w	w.w	PROPN
admet-42	277	12	.	.	PROPN
admet-42	277	13	van	van	PROPN
admet-42	277	14	osdol	osdol	NOUN
admet-42	277	15	,	,	PUNCT
admet-42	277	16	j.	j.	PROPN
admet-42	277	17	membr	membr	PROPN
admet-42	277	18	.	.	PUNCT
admet-42	278	1	sci	sci	PROPN
admet-42	278	2	.	.	PROPN
admet-42	278	3	20	20	NUM
admet-42	278	4	(	(	PUNCT
admet-42	278	5	2007	2007	NUM
admet-42	278	6	)	)	PUNCT
admet-42	278	7	174	174	NUM
admet-42	278	8	-	-	SYM
admet-42	278	9	182	182	NUM
admet-42	278	10	.	.	PUNCT
admet-42	279	1	[	[	X
admet-42	279	2	16	16	NUM
admet-42	279	3	]	]	X
admet-42	279	4	b.d	b.d	PROPN
admet-42	279	5	.	.	PROPN
admet-42	279	6	weinberg	weinberg	PROPN
admet-42	279	7	,	,	PUNCT
admet-42	279	8	e.	e.	PROPN
admet-42	279	9	blanco	blanco	PROPN
admet-42	279	10	,	,	PUNCT
admet-42	279	11	j.	j.	PROPN
admet-42	279	12	gao	gao	PROPN
admet-42	279	13	,	,	PUNCT
admet-42	279	14	j.	j.	PROPN
admet-42	279	15	pharm	pharm	PROPN
admet-42	279	16	.	.	PUNCT
admet-42	280	1	sci	sci	PROPN
admet-42	280	2	.	.	PROPN
admet-42	280	3	97	97	NUM
admet-42	280	4	(	(	PUNCT
admet-42	280	5	2008	2008	NUM
admet-42	280	6	)	)	PUNCT
admet-42	280	7	1681	1681	NUM
admet-42	280	8	-	-	SYM
admet-42	280	9	1702	1702	NUM
admet-42	280	10	.	.	PUNCT
admet-42	281	1	[	[	X
admet-42	281	2	17	17	NUM
admet-42	281	3	]	]	X
admet-42	281	4	y.g	y.g	PROPN
admet-42	281	5	.	.	PROPN
admet-42	281	6	anissimov	anissimov	PROPN
admet-42	281	7	,	,	PUNCT
admet-42	281	8	m.s	m.s	PROPN
admet-42	281	9	.	.	PROPN
admet-42	281	10	roberts	roberts	PROPN
admet-42	281	11	,	,	PUNCT
admet-42	281	12	pharm	pharm	PROPN
admet-42	281	13	.	.	PUNCT
admet-42	282	1	res	re	NOUN
admet-42	282	2	.	.	PUNCT
admet-42	283	1	28	28	NUM
admet-42	283	2	(	(	PUNCT
admet-42	283	3	2011	2011	NUM
admet-42	283	4	)	)	PUNCT
admet-42	283	5	2119	2119	NUM
admet-42	283	6	-	-	SYM
admet-42	283	7	2129	2129	NUM
admet-42	283	8	.	.	PUNCT
admet-42	284	1	[	[	X
admet-42	284	2	18	18	NUM
admet-42	284	3	]	]	X
admet-42	284	4	l.	l.	PROPN
admet-42	284	5	hu	hu	PROPN
admet-42	284	6	,	,	PUNCT
admet-42	284	7	m.g	m.g	PROPN
admet-42	284	8	.	.	PROPN
admet-42	284	9	wientjes	wientjes	PROPN
admet-42	284	10	,	,	PUNCT
admet-42	284	11	j.	j.	PROPN
admet-42	284	12	li	li	PROPN
admet-42	284	13	,	,	PUNCT
admet-42	284	14	j.l	j.l	PROPN
admet-42	284	15	.	.	PROPN
admet-42	284	16	au	au	PROPN
admet-42	284	17	,	,	PUNCT
admet-42	284	18	aaps	aaps	PROPN
admet-42	284	19	j.	j.	PROPN
admet-42	284	20	12	12	NUM
admet-42	284	21	(	(	PUNCT
admet-42	284	22	2010	2010	NUM
admet-42	284	23	)	)	PUNCT
admet-42	284	24	586	586	NUM
admet-42	284	25	-	-	SYM
admet-42	284	26	591	591	NUM
admet-42	284	27	.	.	PUNCT
admet-42	285	1	[	[	X
admet-42	285	2	19	19	NUM
admet-42	285	3	]	]	PUNCT
admet-42	285	4	k.	k.	PROPN
admet-42	285	5	sugibayashi	sugibayashi	PROPN
admet-42	285	6	,	,	PUNCT
admet-42	285	7	h.	h.	PROPN
admet-42	285	8	todo	todo	PROPN
admet-42	285	9	,	,	PUNCT
admet-42	285	10	t.	t.	PROPN
admet-42	285	11	oshizaka	oshizaka	PROPN
admet-42	285	12	,	,	PUNCT
admet-42	285	13	y.	y.	PROPN
admet-42	285	14	owada	owada	PROPN
admet-42	285	15	,	,	PUNCT
admet-42	285	16	pharm	pharm	PROPN
admet-42	285	17	.	.	PUNCT
admet-42	286	1	res	re	NOUN
admet-42	286	2	.	.	PROPN
admet-42	287	1	27	27	NUM
admet-42	287	2	(	(	PUNCT
admet-42	287	3	2010	2010	NUM
admet-42	287	4	)	)	PUNCT
admet-42	287	5	134	134	NUM
admet-42	287	6	-	-	SYM
admet-42	287	7	142	142	NUM
admet-42	287	8	.	.	PUNCT
admet-42	288	1	[	[	X
admet-42	288	2	20	20	NUM
admet-42	288	3	]	]	PUNCT
admet-42	288	4	h.	h.	PROPN
admet-42	288	5	ishii	ishii	PROPN
admet-42	288	6	,	,	PUNCT
admet-42	288	7	h.	h.	PROPN
admet-42	288	8	todo	todo	PROPN
admet-42	288	9	,	,	PUNCT
admet-42	288	10	k.	k.	PROPN
admet-42	288	11	sugibayashi	sugibayashi	PROPN
admet-42	288	12	,	,	PUNCT
admet-42	288	13	chem	chem	NOUN
admet-42	288	14	.	.	PUNCT
admet-42	289	1	pharm	pharm	NOUN
admet-42	289	2	.	.	PUNCT
admet-42	290	1	bull	bull	NOUN
admet-42	290	2	.	.	PUNCT
admet-42	291	1	58	58	NUM
admet-42	291	2	(	(	PUNCT
admet-42	291	3	2010	2010	NUM
admet-42	291	4	)	)	PUNCT
admet-42	291	5	556	556	NUM
admet-42	291	6	-	-	SYM
admet-42	291	7	561	561	NUM
admet-42	291	8	.	.	PUNCT
admet-42	292	1	[	[	X
admet-42	292	2	21	21	NUM
admet-42	292	3	]	]	X
admet-42	292	4	h.	h.	PROPN
admet-42	292	5	ishii	ishii	PROPN
admet-42	292	6	,	,	PUNCT
admet-42	292	7	k.	k.	PROPN
admet-42	292	8	fujino	fujino	PROPN
admet-42	292	9	,	,	PUNCT
admet-42	292	10	h.	h.	PROPN
admet-42	292	11	todo	todo	PROPN
admet-42	292	12	,	,	PUNCT
admet-42	292	13	k.	k.	PROPN
admet-42	292	14	sugibayashi	sugibayashi	PROPN
admet-42	292	15	,	,	PUNCT
admet-42	292	16	exp	exp	PROPN
admet-42	292	17	.	.	PUNCT
admet-42	292	18	anim	anim	NOUN
admet-42	292	19	.	.	PUNCT
admet-42	293	1	61	61	NUM
admet-42	293	2	(	(	PUNCT
admet-42	293	3	2012	2012	NUM
admet-42	293	4	)	)	PUNCT
admet-42	293	5	147	147	NUM
admet-42	293	6	-	-	SYM
admet-42	293	7	156	156	NUM
admet-42	293	8	.	.	PUNCT
admet-42	294	1	sugibayashi	sugibayashi	PROPN
admet-42	294	2	et.al	et.al	PROPN
admet-42	294	3	.	.	PUNCT
admet-42	295	1	admet	admet	PROPN
admet-42	295	2	&	&	CCONJ
admet-42	295	3	dmpk	dmpk	PROPN
admet-42	295	4	2(4	2(4	NUM
admet-42	295	5	)	)	PUNCT
admet-42	295	6	(	(	PUNCT
admet-42	295	7	2014	2014	NUM
admet-42	295	8	)	)	PUNCT
admet-42	295	9	221	221	NUM
admet-42	295	10	-	-	SYM
admet-42	295	11	234	234	NUM
admet-42	295	12	234	234	NUM
admet-42	295	13	[	[	X
admet-42	295	14	22	22	NUM
admet-42	295	15	]	]	X
admet-42	295	16	n.	n.	PROPN
admet-42	295	17	hada	hada	PROPN
admet-42	295	18	,	,	PUNCT
admet-42	295	19	t.	t.	PROPN
admet-42	295	20	hasegawa	hasegawa	PROPN
admet-42	295	21	,	,	PUNCT
admet-42	295	22	h.	h.	PROPN
admet-42	295	23	takahashi	takahashi	PROPN
admet-42	295	24	,	,	PUNCT
admet-42	295	25	t.	t.	PROPN
admet-42	295	26	ishibashi	ishibashi	PROPN
admet-42	295	27	,	,	PUNCT
admet-42	295	28	k.	k.	PROPN
admet-42	295	29	sugibayashi	sugibayashi	PROPN
admet-42	295	30	,	,	PUNCT
admet-42	295	31	j.	j.	PROPN
admet-42	295	32	control	control	PROPN
admet-42	295	33	.	.	PUNCT
admet-42	296	1	release	release	VERB
admet-42	296	2	108	108	NUM
admet-42	296	3	(	(	PUNCT
admet-42	296	4	2005	2005	NUM
admet-42	296	5	)	)	PUNCT
admet-42	296	6	341350	341350	NUM
admet-42	296	7	.	.	PUNCT
admet-42	297	1	[	[	X
admet-42	297	2	23	23	NUM
admet-42	297	3	]	]	X
admet-42	297	4	s.	s.	PROPN
admet-42	297	5	geinoz	geinoz	PROPN
admet-42	297	6	,	,	PUNCT
admet-42	297	7	s.	s.	PROPN
admet-42	297	8	rey	rey	PROPN
admet-42	297	9	,	,	PUNCT
admet-42	297	10	g.	g.	PROPN
admet-42	297	11	boss	boss	PROPN
admet-42	297	12	,	,	PUNCT
admet-42	297	13	a.l	a.l	PROPN
admet-42	297	14	.	.	PROPN
admet-42	297	15	bunge	bunge	PROPN
admet-42	297	16	,	,	PUNCT
admet-42	297	17	r.h	r.h	PROPN
admet-42	297	18	.	.	PROPN
admet-42	297	19	guy	guy	PROPN
admet-42	297	20	,	,	PUNCT
admet-42	297	21	p.a	p.a	PROPN
admet-42	297	22	.	.	PROPN
admet-42	297	23	carrupt	carrupt	PROPN
admet-42	297	24	,	,	PUNCT
admet-42	297	25	m.	m.	NOUN
admet-42	297	26	reist	reist	PROPN
admet-42	297	27	,	,	PUNCT
admet-42	297	28	b.	b.	PROPN
admet-42	297	29	testa	testa	PROPN
admet-42	297	30	,	,	PUNCT
admet-42	297	31	pharm	pharm	NOUN
admet-42	297	32	.	.	PUNCT
admet-42	298	1	res	re	NOUN
admet-42	298	2	.	.	PROPN
admet-42	299	1	19	19	NUM
admet-42	299	2	(	(	PUNCT
admet-42	299	3	2002	2002	NUM
admet-42	299	4	)	)	PUNCT
admet-42	299	5	1622	1622	NUM
admet-42	299	6	-	-	SYM
admet-42	299	7	1629	1629	NUM
admet-42	299	8	.	.	PUNCT
admet-42	300	1	[	[	X
admet-42	300	2	24	24	NUM
admet-42	300	3	]	]	PUNCT
admet-42	300	4	k.	k.	PROPN
admet-42	300	5	sato	sato	PROPN
admet-42	300	6	,	,	PUNCT
admet-42	300	7	n.	n.	PROPN
admet-42	300	8	mitsui	mitsui	PROPN
admet-42	300	9	,	,	PUNCT
admet-42	300	10	t.	t.	PROPN
admet-42	300	11	hasegawa	hasegawa	PROPN
admet-42	300	12	,	,	PUNCT
admet-42	300	13	k.	k.	PROPN
admet-42	300	14	sugibayashi	sugibayashi	PROPN
admet-42	300	15	,	,	PUNCT
admet-42	300	16	y.	y.	PROPN
admet-42	300	17	morimoto	morimoto	PROPN
admet-42	300	18	,	,	PUNCT
admet-42	300	19	j.	j.	PROPN
admet-42	300	20	control	control	PROPN
admet-42	300	21	.	.	PUNCT
admet-42	301	1	release	release	VERB
admet-42	301	2	73	73	NUM
admet-42	301	3	(	(	PUNCT
admet-42	301	4	2001	2001	NUM
admet-42	301	5	)	)	PUNCT
admet-42	301	6	269	269	NUM
admet-42	301	7	-	-	SYM
admet-42	301	8	277	277	NUM
admet-42	301	9	.	.	PUNCT
admet-42	302	1	[	[	X
admet-42	302	2	25	25	NUM
admet-42	302	3	]	]	PUNCT
admet-42	302	4	k.	k.	PROPN
admet-42	302	5	sugibayashi	sugibayashi	PROPN
admet-42	302	6	,	,	PUNCT
admet-42	302	7	t.	t.	PROPN
admet-42	302	8	hayashi	hayashi	PROPN
admet-42	302	9	,	,	PUNCT
admet-42	302	10	k.	k.	PROPN
admet-42	302	11	matsumoto	matsumoto	PROPN
admet-42	302	12	,	,	PUNCT
admet-42	302	13	t.	t.	PROPN
admet-42	302	14	hasegawa	hasegawa	PROPN
admet-42	302	15	,	,	PUNCT
admet-42	302	16	drug	drug	NOUN
admet-42	302	17	metab	metab	NOUN
admet-42	302	18	.	.	PUNCT
admet-42	303	1	pharmacokinet	pharmacokinet	NOUN
admet-42	303	2	.	.	PUNCT
admet-42	304	1	19	19	NUM
admet-42	304	2	(	(	PUNCT
admet-42	304	3	2004	2004	NUM
admet-42	304	4	)	)	PUNCT
admet-42	304	5	352362	352362	NUM
admet-42	304	6	.	.	PUNCT
admet-42	305	1	[	[	X
admet-42	305	2	26	26	NUM
admet-42	305	3	]	]	X
admet-42	305	4	r.j	r.j	PROPN
admet-42	305	5	.	.	PROPN
admet-42	305	6	scheuplein	scheuplein	PROPN
admet-42	305	7	,	,	PUNCT
admet-42	305	8	i.h	i.h	PROPN
admet-42	305	9	.	.	PROPN
admet-42	305	10	blank	blank	PROPN
admet-42	305	11	,	,	PUNCT
admet-42	305	12	j.	j.	PROPN
admet-42	305	13	invest	invest	PROPN
admet-42	305	14	.	.	PUNCT
admet-42	306	1	dermatol	dermatol	NOUN
admet-42	306	2	.	.	PUNCT
admet-42	307	1	60	60	NUM
admet-42	307	2	(	(	PUNCT
admet-42	307	3	1973	1973	NUM
admet-42	307	4	)	)	PUNCT
admet-42	307	5	286	286	NUM
admet-42	307	6	-	-	SYM
admet-42	307	7	296	296	NUM
admet-42	307	8	.	.	PUNCT
admet-42	308	1	[	[	X
admet-42	308	2	27	27	NUM
admet-42	308	3	]	]	X
admet-42	308	4	k.	k.	PROPN
admet-42	308	5	sugibayashi	sugibayashi	PROPN
admet-42	308	6	,	,	PUNCT
admet-42	308	7	t.	t.	PROPN
admet-42	308	8	hayashi	hayashi	PROPN
admet-42	308	9	,	,	PUNCT
admet-42	308	10	t.	t.	PROPN
admet-42	308	11	hatanaka	hatanaka	PROPN
admet-42	308	12	,	,	PUNCT
admet-42	308	13	m.	m.	NOUN
admet-42	308	14	ogihara	ogihara	PROPN
admet-42	308	15	,	,	PUNCT
admet-42	308	16	y.	y.	PROPN
admet-42	308	17	morimoto	morimoto	PROPN
admet-42	308	18	,	,	PUNCT
admet-42	308	19	pharm	pharm	PROPN
admet-42	308	20	.	.	PUNCT
admet-42	309	1	res	re	NOUN
admet-42	309	2	.	.	PROPN
admet-42	309	3	13	13	NUM
admet-42	309	4	(	(	PUNCT
admet-42	309	5	1996	1996	NUM
admet-42	309	6	)	)	PUNCT
admet-42	309	7	855	855	NUM
admet-42	309	8	-	-	SYM
admet-42	309	9	860	860	NUM
admet-42	309	10	.	.	PUNCT
admet-42	310	1	[	[	X
admet-42	310	2	28	28	NUM
admet-42	310	3	]	]	X
admet-42	310	4	h.	h.	PROPN
admet-42	310	5	takeuchi	takeuchi	PROPN
admet-42	310	6	,	,	PUNCT
admet-42	310	7	m.	m.	PROPN
admet-42	310	8	ishida	ishida	PROPN
admet-42	310	9	,	,	PUNCT
admet-42	310	10	a.	a.	NOUN
admet-42	310	11	furuya	furuya	PROPN
admet-42	310	12	,	,	PUNCT
admet-42	310	13	h.	h.	PROPN
admet-42	310	14	todo	todo	PROPN
admet-42	310	15	,	,	PUNCT
admet-42	310	16	h.	h.	PROPN
admet-42	310	17	urano	urano	PROPN
admet-42	310	18	,	,	PUNCT
admet-42	310	19	k.	k.	PROPN
admet-42	310	20	sugibayashi	sugibayashi	PROPN
admet-42	310	21	,	,	PUNCT
admet-42	310	22	biol	biol	PROPN
admet-42	310	23	.	.	PUNCT
admet-42	311	1	pharm	pharm	PROPN
admet-42	311	2	.	.	PUNCT
admet-42	312	1	bull	bull	NOUN
admet-42	312	2	.	.	PUNCT
admet-42	313	1	32	32	NUM
admet-42	313	2	(	(	PUNCT
admet-42	313	3	2012	2012	NUM
admet-42	313	4	)	)	PUNCT
admet-42	313	5	192202	192202	NUM
admet-42	313	6	.	.	PUNCT
admet-42	314	1	[	[	X
admet-42	314	2	29	29	NUM
admet-42	314	3	]	]	X
admet-42	314	4	r.	r.	PROPN
admet-42	314	5	alvarez	alvarez	PROPN
admet-42	314	6	-	-	PUNCT
admet-42	314	7	román	román	PROPN
admet-42	314	8	,	,	PUNCT
admet-42	314	9	a.	a.	PROPN
admet-42	314	10	naik	naik	PROPN
admet-42	314	11	,	,	PUNCT
admet-42	314	12	y.n	y.n	PROPN
admet-42	314	13	.	.	PROPN
admet-42	314	14	kalia	kalia	PROPN
admet-42	314	15	,	,	PUNCT
admet-42	314	16	h.	h.	PROPN
admet-42	314	17	fessia	fessia	PROPN
admet-42	314	18	,	,	PUNCT
admet-42	314	19	r.h	r.h	PROPN
admet-42	314	20	.	.	PROPN
admet-42	314	21	guy	guy	NOUN
admet-42	314	22	,	,	PUNCT
admet-42	314	23	eur	eur	PROPN
admet-42	314	24	.	.	PUNCT
admet-42	315	1	j.	j.	PROPN
admet-42	315	2	pharm	pharm	PROPN
admet-42	315	3	.	.	PUNCT
admet-42	316	1	biopharm	biopharm	PROPN
admet-42	316	2	.	.	PUNCT
admet-42	317	1	58	58	NUM
admet-42	317	2	(	(	PUNCT
admet-42	317	3	2004	2004	NUM
admet-42	317	4	)	)	PUNCT
admet-42	317	5	301316	301316	NUM
admet-42	317	6	.	.	PUNCT
admet-42	318	1	©	©	PROPN
admet-42	318	2	2014	2014	NUM
admet-42	318	3	by	by	ADP
admet-42	318	4	the	the	DET
admet-42	318	5	authors	author	NOUN
admet-42	318	6	;	;	PUNCT
admet-42	318	7	licensee	licensee	PROPN
admet-42	318	8	iapc	iapc	PROPN
admet-42	318	9	,	,	PUNCT
admet-42	318	10	zagreb	zagreb	PROPN
admet-42	318	11	,	,	PUNCT
admet-42	318	12	croatia	croatia	PROPN
admet-42	318	13	.	.	PUNCT
admet-42	319	1	this	this	DET
admet-42	319	2	article	article	NOUN
admet-42	319	3	is	be	AUX
admet-42	319	4	an	an	DET
admet-42	319	5	open	open	ADJ
admet-42	319	6	-	-	PUNCT
admet-42	319	7	access	access	NOUN
admet-42	319	8	article	article	NOUN
admet-42	319	9	distributed	distribute	VERB
admet-42	319	10	under	under	ADP
admet-42	319	11	the	the	DET
admet-42	319	12	terms	term	NOUN
admet-42	319	13	and	and	CCONJ
admet-42	319	14	conditions	condition	NOUN
admet-42	319	15	of	of	ADP
admet-42	319	16	the	the	DET
admet-42	319	17	creative	creative	ADJ
admet-42	319	18	commons	common	NOUN
admet-42	319	19	attribution	attribution	NOUN
admet-42	319	20	license	license	NOUN
admet-42	319	21	(	(	PUNCT
admet-42	319	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-42	319	23	)	)	PUNCT
admet-42	319	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN