id	sid	tid	token	lemma	pos
admet-441	1	1	utilizing	utilize	VERB
admet-441	1	2	in	in	ADP
admet-441	1	3	vitro	vitro	X
admet-441	1	4	transporter	transporter	NOUN
admet-441	1	5	data	datum	NOUN
admet-441	1	6	in	in	ADP
admet-441	1	7	ivive	ivive	ADJ
admet-441	1	8	-	-	PUNCT
admet-441	1	9	pbpk	pbpk	ADJ
admet-441	1	10	:	:	PUNCT
admet-441	1	11	an	an	DET
admet-441	1	12	overview	overview	NOUN
admet-441	1	13	doi	doi	NOUN
admet-441	1	14	:	:	PUNCT
admet-441	1	15	10.5599	10.5599	NUM
admet-441	1	16	/	/	SYM
admet-441	1	17	admet.5.4.441	admet.5.4.441	NUM
admet-441	1	18	201	201	NUM
admet-441	1	19	admet	admet	X
admet-441	1	20	&	&	CCONJ
admet-441	1	21	dmpk	dmpk	PROPN
admet-441	1	22	5(4	5(4	NOUN
admet-441	1	23	)	)	PUNCT
admet-441	1	24	(	(	PUNCT
admet-441	1	25	2017	2017	NUM
admet-441	1	26	)	)	PUNCT
admet-441	1	27	201	201	NUM
admet-441	1	28	-	-	SYM
admet-441	1	29	211	211	NUM
admet-441	1	30	;	;	PUNCT
admet-441	1	31	doi	doi	NOUN
admet-441	1	32	:	:	PUNCT
admet-441	1	33	http://dx.doi.org/10.5599/admet.5.4.441	http://dx.doi.org/10.5599/admet.5.4.441	X
admet-441	1	34	open	open	ADJ
admet-441	1	35	access	access	NOUN
admet-441	1	36	:	:	PUNCT
admet-441	1	37	issn	issn	PROPN
admet-441	1	38	:	:	PUNCT
admet-441	1	39	1848	1848	NUM
admet-441	1	40	-	-	SYM
admet-441	1	41	7718	7718	NUM
admet-441	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-441	1	43	review	review	NOUN
admet-441	1	44	utilizing	utilize	VERB
admet-441	1	45	in	in	ADP
admet-441	1	46	vitro	vitro	X
admet-441	1	47	transporter	transporter	NOUN
admet-441	1	48	data	datum	NOUN
admet-441	1	49	in	in	ADP
admet-441	1	50	ivive	ivive	ADJ
admet-441	1	51	-	-	PUNCT
admet-441	1	52	pbpk	pbpk	ADJ
admet-441	1	53	:	:	PUNCT
admet-441	1	54	an	an	DET
admet-441	1	55	overview	overview	NOUN
admet-441	1	56	pankajini	pankajini	PROPN
admet-441	1	57	mallick	mallick	PROPN
admet-441	1	58	college	college	PROPN
admet-441	1	59	of	of	ADP
admet-441	1	60	pharmacy	pharmacy	NOUN
admet-441	1	61	,	,	PUNCT
admet-441	1	62	department	department	NOUN
admet-441	1	63	of	of	ADP
admet-441	1	64	pharmacological	pharmacological	NOUN
admet-441	1	65	and	and	CCONJ
admet-441	1	66	pharmaceutical	pharmaceutical	NOUN
admet-441	1	67	sciences	science	NOUN
admet-441	1	68	,	,	PUNCT
admet-441	1	69	university	university	NOUN
admet-441	1	70	of	of	ADP
admet-441	1	71	houston	houston	PROPN
admet-441	1	72	,	,	PUNCT
admet-441	1	73	houston	houston	PROPN
admet-441	1	74	,	,	PUNCT
admet-441	1	75	tx	tx	PROPN
admet-441	1	76	77030	77030	NUM
admet-441	1	77	,	,	PUNCT
admet-441	1	78	usa	usa	PROPN
admet-441	1	79	*	*	PUNCT
admet-441	1	80	corresponding	correspond	VERB
admet-441	1	81	author	author	NOUN
admet-441	1	82	:	:	PUNCT
admet-441	1	83	e	e	NOUN
admet-441	1	84	-	-	NOUN
admet-441	1	85	mail	mail	NOUN
admet-441	1	86	:	:	PUNCT
admet-441	1	87	pankajini.mallick@gmail.com	pankajini.mallick@gmail.com	NOUN
admet-441	1	88	;	;	PUNCT
admet-441	1	89	tel	tel	PROPN
admet-441	1	90	.	.	PROPN
admet-441	1	91	:	:	PUNCT
admet-441	1	92	832	832	NUM
admet-441	1	93	-	-	SYM
admet-441	1	94	842	842	NUM
admet-441	1	95	-	-	PUNCT
admet-441	1	96	8343	8343	NUM
admet-441	1	97	received	receive	VERB
admet-441	1	98	:	:	PUNCT
admet-441	1	99	september	september	PROPN
admet-441	1	100	18	18	NUM
admet-441	1	101	,	,	PUNCT
admet-441	1	102	2017	2017	NUM
admet-441	1	103	;	;	PUNCT
admet-441	1	104	revised	revise	VERB
admet-441	1	105	:	:	PUNCT
admet-441	1	106	september	september	PROPN
admet-441	1	107	30	30	NUM
admet-441	1	108	,	,	PUNCT
admet-441	1	109	2017	2017	NUM
admet-441	1	110	;	;	PUNCT
admet-441	1	111	published	publish	VERB
admet-441	1	112	:	:	PUNCT
admet-441	1	113	december	december	PROPN
admet-441	1	114	24	24	NUM
admet-441	1	115	,	,	PUNCT
admet-441	1	116	2017	2017	NUM
admet-441	1	117	abstract	abstract	NOUN
admet-441	1	118	in	in	ADP
admet-441	1	119	vitro	vitro	NOUN
admet-441	1	120	-	-	PUNCT
admet-441	1	121	in	in	ADP
admet-441	1	122	vivo	vivo	ADJ
admet-441	1	123	extrapolation	extrapolation	NOUN
admet-441	1	124	(	(	PUNCT
admet-441	1	125	ivive	ivive	ADJ
admet-441	1	126	)	)	PUNCT
admet-441	1	127	integrated	integrate	VERB
admet-441	1	128	in	in	ADP
admet-441	1	129	physiologically	physiologically	ADV
admet-441	1	130	-	-	PUNCT
admet-441	1	131	based	base	VERB
admet-441	1	132	pharmacokinetic	pharmacokinetic	ADJ
admet-441	1	133	(	(	PUNCT
admet-441	1	134	pbpk	pbpk	NOUN
admet-441	1	135	)	)	PUNCT
admet-441	1	136	models	model	NOUN
admet-441	1	137	have	have	AUX
admet-441	1	138	been	be	AUX
admet-441	1	139	increasingly	increasingly	ADV
admet-441	1	140	used	use	VERB
admet-441	1	141	during	during	ADP
admet-441	1	142	drug	drug	NOUN
admet-441	1	143	discovery	discovery	NOUN
admet-441	1	144	and	and	CCONJ
admet-441	1	145	development	development	NOUN
admet-441	1	146	processes	process	NOUN
admet-441	1	147	to	to	PART
admet-441	1	148	predict	predict	VERB
admet-441	1	149	human	human	ADJ
admet-441	1	150	pharmacokinetic	pharmacokinetic	ADJ
admet-441	1	151	(	(	PUNCT
admet-441	1	152	pk	pk	NOUN
admet-441	1	153	)	)	PUNCT
admet-441	1	154	parameters	parameter	NOUN
admet-441	1	155	.	.	PUNCT
admet-441	2	1	drug	drug	NOUN
admet-441	2	2	transporters	transporter	NOUN
admet-441	2	3	can	can	AUX
admet-441	2	4	influence	influence	VERB
admet-441	2	5	drug	drug	NOUN
admet-441	2	6	pharmacokinetics	pharmacokinetic	NOUN
admet-441	2	7	and	and	CCONJ
admet-441	2	8	are	be	AUX
admet-441	2	9	key	key	ADJ
admet-441	2	10	aspects	aspect	NOUN
admet-441	2	11	contributing	contribute	VERB
admet-441	2	12	to	to	ADP
admet-441	2	13	the	the	DET
admet-441	2	14	development	development	NOUN
admet-441	2	15	of	of	ADP
admet-441	2	16	a	a	DET
admet-441	2	17	successful	successful	ADJ
admet-441	2	18	drug	drug	NOUN
admet-441	2	19	.	.	PUNCT
admet-441	3	1	this	this	DET
admet-441	3	2	review	review	NOUN
admet-441	3	3	provides	provide	VERB
admet-441	3	4	a	a	DET
admet-441	3	5	snapshot	snapshot	NOUN
admet-441	3	6	of	of	ADP
admet-441	3	7	challenges	challenge	NOUN
admet-441	3	8	or	or	CCONJ
admet-441	3	9	shortcomings	shortcoming	NOUN
admet-441	3	10	of	of	ADP
admet-441	3	11	in	in	ADP
admet-441	3	12	vitro	vitro	X
admet-441	3	13	and	and	CCONJ
admet-441	3	14	in	in	ADP
admet-441	3	15	vivo	vivo	ADJ
admet-441	3	16	techniques	technique	NOUN
admet-441	3	17	for	for	ADP
admet-441	3	18	understanding	understand	VERB
admet-441	3	19	the	the	DET
admet-441	3	20	contribution	contribution	NOUN
admet-441	3	21	of	of	ADP
admet-441	3	22	drug	drug	NOUN
admet-441	3	23	transporters	transporter	NOUN
admet-441	3	24	to	to	ADP
admet-441	3	25	a	a	DET
admet-441	3	26	drug	drug	NOUN
admet-441	3	27	’s	’s	PART
admet-441	3	28	pharmacokinetics	pharmacokinetic	NOUN
admet-441	3	29	.	.	PUNCT
admet-441	4	1	the	the	DET
admet-441	4	2	paper	paper	NOUN
admet-441	4	3	also	also	ADV
admet-441	4	4	describes	describe	VERB
admet-441	4	5	the	the	DET
admet-441	4	6	potential	potential	NOUN
admet-441	4	7	of	of	ADP
admet-441	4	8	ivive	ivive	ADJ
admet-441	4	9	-	-	PUNCT
admet-441	4	10	pbpk	pbpk	ADJ
admet-441	4	11	models	model	NOUN
admet-441	4	12	as	as	ADP
admet-441	4	13	prospective	prospective	ADJ
admet-441	4	14	approaches	approach	NOUN
admet-441	4	15	to	to	PART
admet-441	4	16	predict	predict	VERB
admet-441	4	17	the	the	DET
admet-441	4	18	role	role	NOUN
admet-441	4	19	of	of	ADP
admet-441	4	20	drug	drug	NOUN
admet-441	4	21	transporters	transporter	NOUN
admet-441	4	22	in	in	ADP
admet-441	4	23	drug	drug	NOUN
admet-441	4	24	discovery	discovery	NOUN
admet-441	4	25	and	and	CCONJ
admet-441	4	26	development	development	NOUN
admet-441	4	27	.	.	PUNCT
admet-441	5	1	keywords	keyword	VERB
admet-441	5	2	pgp	pgp	NOUN
admet-441	5	3	;	;	PUNCT
admet-441	5	4	bile	bile	NOUN
admet-441	5	5	acid	acid	NOUN
admet-441	5	6	transporter	transporter	NOUN
admet-441	5	7	;	;	PUNCT
admet-441	5	8	drug	drug	NOUN
admet-441	5	9	transporters	transporter	NOUN
admet-441	5	10	;	;	PUNCT
admet-441	5	11	drug	drug	NOUN
admet-441	5	12	metabolizing	metabolize	VERB
admet-441	5	13	enzymes	enzyme	NOUN
admet-441	5	14	;	;	PUNCT
admet-441	5	15	drug	drug	NOUN
admet-441	5	16	induced	induce	VERB
admet-441	5	17	liver	liver	NOUN
admet-441	5	18	injury	injury	NOUN
admet-441	5	19	introduction	introduction	NOUN
admet-441	5	20	the	the	DET
admet-441	5	21	role	role	NOUN
admet-441	5	22	of	of	ADP
admet-441	5	23	drug	drug	NOUN
admet-441	5	24	transporters	transporter	NOUN
admet-441	5	25	in	in	ADP
admet-441	5	26	drug	drug	NOUN
admet-441	5	27	efficacy	efficacy	NOUN
admet-441	5	28	and	and	CCONJ
admet-441	5	29	safety	safety	NOUN
admet-441	5	30	has	have	AUX
admet-441	5	31	been	be	AUX
admet-441	5	32	of	of	ADP
admet-441	5	33	much	much	ADJ
admet-441	5	34	interest	interest	NOUN
admet-441	5	35	;	;	PUNCT
admet-441	5	36	drug	drug	NOUN
admet-441	5	37	transports	transport	NOUN
admet-441	5	38	play	play	VERB
admet-441	5	39	key	key	ADJ
admet-441	5	40	roles	role	NOUN
admet-441	5	41	in	in	ADP
admet-441	5	42	drug	drug	NOUN
admet-441	5	43	absorption	absorption	NOUN
admet-441	5	44	,	,	PUNCT
admet-441	5	45	distribution	distribution	NOUN
admet-441	5	46	,	,	PUNCT
admet-441	5	47	and	and	CCONJ
admet-441	5	48	excretion	excretion	NOUN
admet-441	6	1	[	[	X
admet-441	6	2	1	1	NUM
admet-441	6	3	-	-	SYM
admet-441	6	4	3	3	NUM
admet-441	6	5	]	]	PUNCT
admet-441	6	6	.	.	PUNCT
admet-441	7	1	in	in	ADP
admet-441	7	2	drug	drug	NOUN
admet-441	7	3	discovery	discovery	NOUN
admet-441	7	4	and	and	CCONJ
admet-441	7	5	development	development	NOUN
admet-441	7	6	,	,	PUNCT
admet-441	7	7	drug	drug	NOUN
admet-441	7	8	transporters	transporter	NOUN
admet-441	7	9	expressed	express	VERB
admet-441	7	10	in	in	ADP
admet-441	7	11	the	the	DET
admet-441	7	12	intestine	intestine	NOUN
admet-441	7	13	,	,	PUNCT
admet-441	7	14	liver	liver	NOUN
admet-441	7	15	,	,	PUNCT
admet-441	7	16	kidneys	kidney	NOUN
admet-441	7	17	,	,	PUNCT
admet-441	7	18	and	and	CCONJ
admet-441	7	19	brain	brain	NOUN
admet-441	7	20	have	have	AUX
admet-441	7	21	received	receive	VERB
admet-441	7	22	considerable	considerable	ADJ
admet-441	7	23	attention	attention	NOUN
admet-441	8	1	[	[	X
admet-441	8	2	4	4	NUM
admet-441	8	3	-	-	SYM
admet-441	8	4	7	7	NUM
admet-441	8	5	]	]	PUNCT
admet-441	8	6	.	.	PUNCT
admet-441	9	1	many	many	ADJ
admet-441	9	2	of	of	ADP
admet-441	9	3	the	the	DET
admet-441	9	4	drug	drug	NOUN
admet-441	9	5	transporters	transporter	NOUN
admet-441	9	6	that	that	PRON
admet-441	9	7	have	have	AUX
admet-441	9	8	been	be	AUX
admet-441	9	9	cloned	clone	VERB
admet-441	9	10	and	and	CCONJ
admet-441	9	11	characterized	characterize	VERB
admet-441	9	12	belong	belong	VERB
admet-441	9	13	to	to	ADP
admet-441	9	14	two	two	NUM
admet-441	9	15	major	major	ADJ
admet-441	9	16	superfamilies	superfamily	NOUN
admet-441	9	17	,	,	PUNCT
admet-441	9	18	atp	atp	NOUN
admet-441	9	19	-	-	PUNCT
admet-441	9	20	binding	bind	VERB
admet-441	9	21	cassette	cassette	NOUN
admet-441	9	22	(	(	PUNCT
admet-441	9	23	abc	abc	PROPN
admet-441	9	24	)	)	PUNCT
admet-441	9	25	and	and	CCONJ
admet-441	9	26	solute	solute	ADJ
admet-441	9	27	carrier	carrier	NOUN
admet-441	9	28	(	(	PUNCT
admet-441	9	29	slc	slc	PROPN
admet-441	9	30	)	)	PUNCT
admet-441	9	31	.	.	PUNCT
admet-441	10	1	major	major	ADJ
admet-441	10	2	efflux	efflux	NOUN
admet-441	10	3	transporters	transporter	NOUN
admet-441	10	4	of	of	ADP
admet-441	10	5	the	the	DET
admet-441	10	6	abc	abc	PROPN
admet-441	10	7	family	family	PROPN
admet-441	10	8	include	include	VERB
admet-441	10	9	mdr1	mdr1	PROPN
admet-441	10	10	(	(	PUNCT
admet-441	10	11	p	p	NOUN
admet-441	10	12	-	-	PUNCT
admet-441	10	13	glycoprotein	glycoprotein	NOUN
admet-441	10	14	,	,	PUNCT
admet-441	10	15	abcb1	abcb1	NOUN
admet-441	10	16	)	)	PUNCT
admet-441	10	17	,	,	PUNCT
admet-441	10	18	bcrp	bcrp	PROPN
admet-441	10	19	(	(	PUNCT
admet-441	10	20	abcg2	abcg2	NOUN
admet-441	10	21	)	)	PUNCT
admet-441	10	22	,	,	PUNCT
admet-441	10	23	and	and	CCONJ
admet-441	10	24	mrp2	mrp2	PROPN
admet-441	10	25	(	(	PUNCT
admet-441	10	26	abcc2	abcc2	NOUN
admet-441	10	27	)	)	PUNCT
admet-441	10	28	,	,	PUNCT
admet-441	10	29	and	and	CCONJ
admet-441	10	30	are	be	AUX
admet-441	10	31	localized	localize	VERB
admet-441	10	32	to	to	ADP
admet-441	10	33	barrier	barrier	NOUN
admet-441	10	34	tissues	tissue	NOUN
admet-441	10	35	in	in	ADP
admet-441	10	36	the	the	DET
admet-441	10	37	body	body	NOUN
admet-441	10	38	,	,	PUNCT
admet-441	10	39	such	such	ADJ
admet-441	10	40	as	as	ADP
admet-441	10	41	the	the	DET
admet-441	10	42	intestine	intestine	NOUN
admet-441	10	43	,	,	PUNCT
admet-441	10	44	liver	liver	NOUN
admet-441	10	45	,	,	PUNCT
admet-441	10	46	kidneys	kidney	NOUN
admet-441	10	47	,	,	PUNCT
admet-441	10	48	blood	blood	NOUN
admet-441	10	49	-	-	PUNCT
admet-441	10	50	brain	brain	NOUN
admet-441	10	51	barrier	barrier	NOUN
admet-441	10	52	,	,	PUNCT
admet-441	10	53	and	and	CCONJ
admet-441	10	54	placenta	placenta	NOUN
admet-441	10	55	[	[	X
admet-441	10	56	8	8	NUM
admet-441	10	57	-	-	SYM
admet-441	10	58	11	11	NUM
admet-441	10	59	]	]	PUNCT
admet-441	10	60	.	.	PUNCT
admet-441	11	1	absorption	absorption	NOUN
admet-441	11	2	of	of	ADP
admet-441	11	3	a	a	DET
admet-441	11	4	drug	drug	NOUN
admet-441	11	5	is	be	AUX
admet-441	11	6	a	a	DET
admet-441	11	7	key	key	ADJ
admet-441	11	8	component	component	NOUN
admet-441	11	9	to	to	PART
admet-441	11	10	achieve	achieve	VERB
admet-441	11	11	good	good	ADJ
admet-441	11	12	bioavailability	bioavailability	NOUN
admet-441	11	13	,	,	PUNCT
admet-441	11	14	and	and	CCONJ
admet-441	11	15	for	for	ADP
admet-441	11	16	oral	oral	ADJ
admet-441	11	17	drugs	drug	NOUN
admet-441	11	18	,	,	PUNCT
admet-441	11	19	the	the	DET
admet-441	11	20	majority	majority	NOUN
admet-441	11	21	of	of	ADP
admet-441	11	22	drug	drug	NOUN
admet-441	11	23	absorption	absorption	NOUN
admet-441	11	24	occurs	occur	VERB
admet-441	11	25	in	in	ADP
admet-441	11	26	the	the	DET
admet-441	11	27	small	small	ADJ
admet-441	11	28	intestine	intestine	NOUN
admet-441	11	29	where	where	SCONJ
admet-441	11	30	the	the	DET
admet-441	11	31	presence	presence	NOUN
admet-441	11	32	of	of	ADP
admet-441	11	33	villi	villi	NOUN
admet-441	11	34	and	and	CCONJ
admet-441	11	35	microvilli	microvilli	NOUN
admet-441	11	36	greatly	greatly	ADV
admet-441	11	37	increases	increase	VERB
admet-441	11	38	the	the	DET
admet-441	11	39	surface	surface	NOUN
admet-441	11	40	area	area	NOUN
admet-441	11	41	for	for	ADP
admet-441	11	42	optimal	optimal	ADJ
admet-441	11	43	absorption	absorption	NOUN
admet-441	11	44	.	.	PUNCT
admet-441	12	1	thus	thus	ADV
admet-441	12	2	,	,	PUNCT
admet-441	12	3	drug	drug	NOUN
admet-441	12	4	-	-	PUNCT
admet-441	12	5	transporter	transporter	NOUN
admet-441	12	6	interaction	interaction	NOUN
admet-441	12	7	in	in	ADP
admet-441	12	8	the	the	DET
admet-441	12	9	intestine	intestine	NOUN
admet-441	12	10	often	often	ADV
admet-441	12	11	contributes	contribute	VERB
admet-441	12	12	to	to	ADP
admet-441	12	13	poor	poor	ADJ
admet-441	12	14	absorption	absorption	NOUN
admet-441	12	15	,	,	PUNCT
admet-441	12	16	resulting	result	VERB
admet-441	12	17	in	in	ADP
admet-441	12	18	low	low	ADJ
admet-441	12	19	bioavailability	bioavailability	NOUN
admet-441	12	20	.	.	PUNCT
admet-441	13	1	given	give	VERB
admet-441	13	2	that	that	DET
admet-441	13	3	oral	oral	ADJ
admet-441	13	4	delivery	delivery	NOUN
admet-441	13	5	is	be	AUX
admet-441	13	6	the	the	DET
admet-441	13	7	preferred	preferred	ADJ
admet-441	13	8	route	route	NOUN
admet-441	13	9	of	of	ADP
admet-441	13	10	administration	administration	NOUN
admet-441	13	11	for	for	ADP
admet-441	13	12	drugs	drug	NOUN
admet-441	13	13	,	,	PUNCT
admet-441	13	14	intestinal	intestinal	ADJ
admet-441	13	15	transporters	transporter	NOUN
admet-441	13	16	are	be	AUX
admet-441	13	17	potential	potential	ADJ
admet-441	13	18	targets	target	NOUN
admet-441	13	19	to	to	PART
admet-441	13	20	achieve	achieve	VERB
admet-441	13	21	optimal	optimal	ADJ
admet-441	13	22	clinical	clinical	ADJ
admet-441	13	23	oral	oral	ADJ
admet-441	13	24	plasma	plasma	NOUN
admet-441	13	25	exposure	exposure	NOUN
admet-441	13	26	for	for	ADP
admet-441	13	27	hydrophilic	hydrophilic	ADJ
admet-441	13	28	and	and	CCONJ
admet-441	13	29	polar	polar	ADJ
admet-441	13	30	drugs	drug	NOUN
admet-441	13	31	[	[	X
admet-441	13	32	12	12	NUM
admet-441	13	33	]	]	PUNCT
admet-441	13	34	.	.	PUNCT
admet-441	14	1	although	although	SCONJ
admet-441	14	2	the	the	DET
admet-441	14	3	significance	significance	NOUN
admet-441	14	4	of	of	ADP
admet-441	14	5	drug	drug	NOUN
admet-441	14	6	transporters	transporter	NOUN
admet-441	14	7	in	in	ADP
admet-441	14	8	absorption	absorption	NOUN
admet-441	14	9	,	,	PUNCT
admet-441	14	10	distribution	distribution	NOUN
admet-441	14	11	,	,	PUNCT
admet-441	14	12	metabolism	metabolism	NOUN
admet-441	14	13	,	,	PUNCT
admet-441	14	14	and	and	CCONJ
admet-441	14	15	elimination	elimination	NOUN
admet-441	14	16	(	(	PUNCT
admet-441	14	17	adme	adme	NOUN
admet-441	14	18	)	)	PUNCT
admet-441	14	19	of	of	ADP
admet-441	14	20	drugs	drug	NOUN
admet-441	14	21	is	be	AUX
admet-441	14	22	well	well	ADV
admet-441	14	23	recognized	recognize	VERB
admet-441	14	24	,	,	PUNCT
admet-441	14	25	a	a	DET
admet-441	14	26	knowledge	knowledge	NOUN
admet-441	14	27	gap	gap	NOUN
admet-441	14	28	exists	exist	VERB
admet-441	14	29	in	in	ADP
admet-441	14	30	terms	term	NOUN
admet-441	14	31	of	of	ADP
admet-441	14	32	change	change	NOUN
admet-441	14	33	in	in	ADP
admet-441	14	34	drug	drug	NOUN
admet-441	14	35	transporter	transporter	NOUN
admet-441	14	36	functionality	functionality	NOUN
admet-441	14	37	(	(	PUNCT
admet-441	14	38	their	their	PRON
admet-441	14	39	amount	amount	NOUN
admet-441	14	40	and	and	CCONJ
admet-441	14	41	activity	activity	NOUN
admet-441	14	42	)	)	PUNCT
admet-441	14	43	in	in	ADP
admet-441	14	44	response	response	NOUN
admet-441	14	45	to	to	ADP
admet-441	14	46	disease	disease	NOUN
admet-441	14	47	,	,	PUNCT
admet-441	14	48	and	and	CCONJ
admet-441	14	49	how	how	SCONJ
admet-441	14	50	pathophysiological	pathophysiological	ADJ
admet-441	14	51	pathways	pathway	NOUN
admet-441	14	52	change	change	VERB
admet-441	14	53	transporter	transporter	NOUN
admet-441	14	54	expressions	expression	NOUN
admet-441	14	55	[	[	X
admet-441	14	56	13	13	NUM
admet-441	14	57	]	]	PUNCT
admet-441	14	58	.	.	PUNCT
admet-441	15	1	because	because	SCONJ
admet-441	15	2	of	of	ADP
admet-441	15	3	the	the	DET
admet-441	15	4	central	central	ADJ
admet-441	15	5	role	role	NOUN
admet-441	15	6	of	of	ADP
admet-441	15	7	the	the	DET
admet-441	15	8	liver	liver	NOUN
admet-441	15	9	in	in	ADP
admet-441	15	10	drug	drug	NOUN
admet-441	15	11	metabolism	metabolism	NOUN
admet-441	15	12	,	,	PUNCT
admet-441	15	13	the	the	DET
admet-441	15	14	role	role	NOUN
admet-441	15	15	of	of	ADP
admet-441	15	16	transporters	transporter	NOUN
admet-441	15	17	in	in	ADP
admet-441	15	18	the	the	DET
admet-441	15	19	liver	liver	NOUN
admet-441	15	20	in	in	ADP
admet-441	15	21	drug	drug	NOUN
admet-441	15	22	interactions	interaction	NOUN
admet-441	15	23	and	and	CCONJ
admet-441	15	24	drug	drug	NOUN
admet-441	15	25	responses	response	NOUN
admet-441	15	26	,	,	PUNCT
admet-441	15	27	as	as	ADV
admet-441	15	28	well	well	ADV
admet-441	15	29	as	as	ADP
admet-441	15	30	drug	drug	NOUN
admet-441	15	31	-	-	PUNCT
admet-441	15	32	induced	induce	VERB
admet-441	15	33	liver	liver	NOUN
admet-441	15	34	injury	injury	NOUN
admet-441	15	35	,	,	PUNCT
admet-441	15	36	has	have	AUX
admet-441	15	37	been	be	AUX
admet-441	15	38	in	in	ADP
admet-441	15	39	focus	focus	NOUN
admet-441	15	40	of	of	ADP
admet-441	15	41	late	late	ADJ
admet-441	15	42	.	.	PUNCT
admet-441	16	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-441	16	2	mailto:pankajini.mallick@gmail.com	mailto:pankajini.mallick@gmail.com	X
admet-441	17	1	pankajini	pankajini	PROPN
admet-441	17	2	mallick	mallick	PROPN
admet-441	17	3	admet	admet	PROPN
admet-441	17	4	&	&	CCONJ
admet-441	17	5	dmpk	dmpk	PROPN
admet-441	17	6	5(4	5(4	NOUN
admet-441	17	7	)	)	PUNCT
admet-441	17	8	(	(	PUNCT
admet-441	17	9	2017	2017	NUM
admet-441	17	10	)	)	PUNCT
admet-441	17	11	201	201	NUM
admet-441	17	12	-	-	SYM
admet-441	17	13	211	211	NUM
admet-441	17	14	202	202	NUM
admet-441	17	15	despite	despite	SCONJ
admet-441	17	16	a	a	DET
admet-441	17	17	steady	steady	ADJ
admet-441	17	18	growth	growth	NOUN
admet-441	17	19	in	in	ADP
admet-441	17	20	the	the	DET
admet-441	17	21	field	field	NOUN
admet-441	17	22	of	of	ADP
admet-441	17	23	transporter	transporter	NOUN
admet-441	17	24	biology	biology	NOUN
admet-441	17	25	,	,	PUNCT
admet-441	17	26	which	which	PRON
admet-441	17	27	has	have	AUX
admet-441	17	28	bolstered	bolster	VERB
admet-441	17	29	transporter	transporter	NOUN
admet-441	17	30	-	-	PUNCT
admet-441	17	31	mediated	mediate	VERB
admet-441	17	32	therapeutics	therapeutic	NOUN
admet-441	17	33	,	,	PUNCT
admet-441	17	34	the	the	DET
admet-441	17	35	physiological	physiological	ADJ
admet-441	17	36	functions	function	NOUN
admet-441	17	37	of	of	ADP
admet-441	17	38	many	many	ADJ
admet-441	17	39	transporters	transporter	NOUN
admet-441	17	40	are	be	AUX
admet-441	17	41	still	still	ADV
admet-441	17	42	largely	largely	ADV
admet-441	17	43	unknown	unknown	ADJ
admet-441	17	44	.	.	PUNCT
admet-441	18	1	these	these	DET
admet-441	18	2	growing	grow	VERB
admet-441	18	3	trends	trend	NOUN
admet-441	18	4	bring	bring	VERB
admet-441	18	5	challenges	challenge	NOUN
admet-441	18	6	for	for	ADP
admet-441	18	7	drug	drug	NOUN
admet-441	18	8	development	development	NOUN
admet-441	18	9	,	,	PUNCT
admet-441	18	10	as	as	ADV
admet-441	18	11	well	well	ADV
admet-441	18	12	as	as	ADP
admet-441	18	13	for	for	ADP
admet-441	18	14	regulatory	regulatory	ADJ
admet-441	18	15	agencies	agency	NOUN
admet-441	18	16	,	,	PUNCT
admet-441	18	17	with	with	ADP
admet-441	18	18	regard	regard	NOUN
admet-441	18	19	to	to	ADP
admet-441	18	20	identification	identification	NOUN
admet-441	18	21	of	of	ADP
admet-441	18	22	membrane	membrane	NOUN
admet-441	18	23	transporters	transporter	NOUN
admet-441	18	24	that	that	PRON
admet-441	18	25	influence	influence	VERB
admet-441	18	26	the	the	DET
admet-441	18	27	disposition	disposition	NOUN
admet-441	18	28	and	and	CCONJ
admet-441	18	29	safety	safety	NOUN
admet-441	18	30	of	of	ADP
admet-441	18	31	drugs	drug	NOUN
admet-441	18	32	,	,	PUNCT
admet-441	18	33	and	and	CCONJ
admet-441	18	34	also	also	ADV
admet-441	18	35	optimization	optimization	NOUN
admet-441	18	36	of	of	ADP
admet-441	18	37	membrane	membrane	NOUN
admet-441	18	38	permeability	permeability	NOUN
admet-441	18	39	to	to	PART
admet-441	18	40	improve	improve	VERB
admet-441	18	41	oral	oral	ADJ
admet-441	18	42	absorption	absorption	NOUN
admet-441	18	43	of	of	ADP
admet-441	18	44	new	new	ADJ
admet-441	18	45	chemical	chemical	NOUN
admet-441	18	46	entities	entity	NOUN
admet-441	18	47	.	.	PUNCT
admet-441	19	1	thus	thus	ADV
admet-441	19	2	,	,	PUNCT
admet-441	19	3	utilization	utilization	NOUN
admet-441	19	4	of	of	ADP
admet-441	19	5	in	in	ADP
admet-441	19	6	vitro	vitro	X
admet-441	19	7	transporter	transporter	NOUN
admet-441	19	8	assays	assay	NOUN
admet-441	19	9	has	have	AUX
admet-441	19	10	become	become	VERB
admet-441	19	11	a	a	DET
admet-441	19	12	critical	critical	ADJ
admet-441	19	13	tool	tool	NOUN
admet-441	19	14	for	for	ADP
admet-441	19	15	assessing	assess	VERB
admet-441	19	16	a	a	DET
admet-441	19	17	drug	drug	NOUN
admet-441	19	18	’s	’s	PART
admet-441	19	19	potential	potential	NOUN
admet-441	19	20	in	in	ADP
admet-441	19	21	vivo	vivo	ADJ
admet-441	19	22	absorption	absorption	NOUN
admet-441	19	23	properties	property	NOUN
admet-441	19	24	and	and	CCONJ
admet-441	19	25	drug	drug	NOUN
admet-441	19	26	-	-	PUNCT
admet-441	19	27	drug	drug	NOUN
admet-441	19	28	interactions	interaction	NOUN
admet-441	19	29	[	[	X
admet-441	19	30	14	14	NUM
admet-441	19	31	]	]	PUNCT
admet-441	19	32	.	.	PUNCT
admet-441	20	1	use	use	NOUN
admet-441	20	2	of	of	ADP
admet-441	20	3	in	in	ADP
admet-441	20	4	vitro	vitro	X
admet-441	20	5	–	–	PUNCT
admet-441	20	6	in	in	ADP
admet-441	20	7	vivo	vivo	ADJ
admet-441	20	8	extrapolation	extrapolation	NOUN
admet-441	20	9	(	(	PUNCT
admet-441	20	10	ivive	ivive	ADJ
admet-441	20	11	)	)	PUNCT
admet-441	20	12	integrated	integrate	VERB
admet-441	20	13	in	in	ADP
admet-441	20	14	physiological	physiological	NOUN
admet-441	20	15	-	-	PUNCT
admet-441	20	16	based	base	VERB
admet-441	20	17	pharmacokinetic	pharmacokinetic	ADJ
admet-441	20	18	(	(	PUNCT
admet-441	20	19	pbpk	pbpk	NOUN
admet-441	20	20	)	)	PUNCT
admet-441	20	21	models	model	NOUN
admet-441	20	22	,	,	PUNCT
admet-441	20	23	together	together	ADV
admet-441	20	24	known	know	VERB
admet-441	20	25	as	as	ADP
admet-441	20	26	ivive	ivive	ADJ
admet-441	20	27	-	-	PUNCT
admet-441	20	28	pbpk	pbpk	ADJ
admet-441	20	29	models	model	NOUN
admet-441	20	30	,	,	PUNCT
admet-441	20	31	has	have	AUX
admet-441	20	32	gained	gain	VERB
admet-441	20	33	recent	recent	ADJ
admet-441	20	34	momentum	momentum	NOUN
admet-441	20	35	in	in	ADP
admet-441	20	36	the	the	DET
admet-441	20	37	pharmaceutical	pharmaceutical	ADJ
admet-441	20	38	industry	industry	NOUN
admet-441	20	39	.	.	PUNCT
admet-441	21	1	since	since	SCONJ
admet-441	21	2	variation	variation	NOUN
admet-441	21	3	in	in	ADP
admet-441	21	4	protein	protein	NOUN
admet-441	21	5	expression	expression	NOUN
admet-441	21	6	of	of	ADP
admet-441	21	7	drug	drug	NOUN
admet-441	21	8	metabolizing	metabolize	VERB
admet-441	21	9	enzymes	enzyme	NOUN
admet-441	21	10	and	and	CCONJ
admet-441	21	11	transporters	transporter	NOUN
admet-441	21	12	is	be	AUX
admet-441	21	13	known	know	VERB
admet-441	21	14	to	to	PART
admet-441	21	15	be	be	AUX
admet-441	21	16	a	a	DET
admet-441	21	17	major	major	ADJ
admet-441	21	18	complicating	complicate	VERB
admet-441	21	19	factor	factor	NOUN
admet-441	21	20	in	in	ADP
admet-441	21	21	ivive	ivive	ADJ
admet-441	21	22	,	,	PUNCT
admet-441	21	23	the	the	DET
admet-441	21	24	accurate	accurate	ADJ
admet-441	21	25	quantification	quantification	NOUN
admet-441	21	26	of	of	ADP
admet-441	21	27	these	these	DET
admet-441	21	28	proteins	protein	NOUN
admet-441	21	29	in	in	ADP
admet-441	21	30	complex	complex	ADJ
admet-441	21	31	biological	biological	ADJ
admet-441	21	32	systems	system	NOUN
admet-441	21	33	is	be	AUX
admet-441	21	34	essential	essential	ADJ
admet-441	21	35	for	for	ADP
admet-441	21	36	improving	improve	VERB
admet-441	21	37	ivive	ivive	ADJ
admet-441	21	38	-	-	PUNCT
admet-441	21	39	based	base	VERB
admet-441	21	40	pharmacokinetic	pharmacokinetic	ADJ
admet-441	21	41	predictions	prediction	NOUN
admet-441	21	42	[	[	X
admet-441	21	43	15	15	NUM
admet-441	21	44	]	]	PUNCT
admet-441	21	45	.	.	PUNCT
admet-441	22	1	this	this	DET
admet-441	22	2	review	review	NOUN
admet-441	22	3	focuses	focus	VERB
admet-441	22	4	on	on	ADP
admet-441	22	5	the	the	DET
admet-441	22	6	use	use	NOUN
admet-441	22	7	and	and	CCONJ
admet-441	22	8	shortcomings	shortcoming	NOUN
admet-441	22	9	of	of	ADP
admet-441	22	10	qualitative	qualitative	ADJ
admet-441	22	11	and	and	CCONJ
admet-441	22	12	quantitative	quantitative	ADJ
admet-441	22	13	methods	method	NOUN
admet-441	22	14	used	use	VERB
admet-441	22	15	to	to	PART
admet-441	22	16	create	create	VERB
admet-441	22	17	drug	drug	NOUN
admet-441	22	18	transporter	transporter	NOUN
admet-441	22	19	-	-	PUNCT
admet-441	22	20	based	base	VERB
admet-441	22	21	ivive	ivive	ADJ
admet-441	22	22	-	-	PUNCT
admet-441	22	23	pbpk	pbpk	ADJ
admet-441	22	24	models	model	NOUN
admet-441	22	25	in	in	ADP
admet-441	22	26	the	the	DET
admet-441	22	27	liver	liver	NOUN
admet-441	22	28	,	,	PUNCT
admet-441	22	29	intestine	intestine	NOUN
admet-441	22	30	,	,	PUNCT
admet-441	22	31	and	and	CCONJ
admet-441	22	32	brain	brain	NOUN
admet-441	22	33	.	.	PUNCT
admet-441	23	1	pitfalls	pitfall	NOUN
admet-441	23	2	of	of	ADP
admet-441	23	3	in	in	ADP
admet-441	23	4	vitro	vitro	X
admet-441	23	5	and	and	CCONJ
admet-441	23	6	in	in	ADP
admet-441	23	7	vivo	vivo	ADJ
admet-441	23	8	systems	system	NOUN
admet-441	23	9	used	use	VERB
admet-441	23	10	in	in	ADP
admet-441	23	11	drug	drug	NOUN
admet-441	23	12	transporter	transporter	NOUN
admet-441	23	13	studies	study	NOUN
admet-441	23	14	in	in	ADP
admet-441	23	15	vitro	vitro	X
admet-441	23	16	cell	cell	NOUN
admet-441	23	17	-	-	PUNCT
admet-441	23	18	based	base	VERB
admet-441	23	19	systems	system	NOUN
admet-441	23	20	are	be	AUX
admet-441	23	21	used	use	VERB
admet-441	23	22	routinely	routinely	ADV
admet-441	23	23	to	to	PART
admet-441	23	24	elucidate	elucidate	VERB
admet-441	23	25	passive	passive	ADJ
admet-441	23	26	and	and	CCONJ
admet-441	23	27	active	active	ADJ
admet-441	23	28	transporter	transporter	NOUN
admet-441	23	29	processes	process	NOUN
admet-441	23	30	acting	act	VERB
admet-441	23	31	to	to	ADP
admet-441	23	32	influence	influence	NOUN
admet-441	23	33	drug	drug	NOUN
admet-441	23	34	permeability	permeability	NOUN
admet-441	23	35	.	.	PUNCT
admet-441	24	1	different	different	ADJ
admet-441	24	2	in	in	ADP
admet-441	24	3	vitro	vitro	X
admet-441	24	4	systems	system	NOUN
admet-441	24	5	include	include	VERB
admet-441	24	6	use	use	NOUN
admet-441	24	7	of	of	ADP
admet-441	24	8	membrane	membrane	NOUN
admet-441	24	9	vesicles	vesicle	NOUN
admet-441	24	10	or	or	CCONJ
admet-441	24	11	transfected	transfecte	VERB
admet-441	24	12	cell	cell	NOUN
admet-441	24	13	lines	line	NOUN
admet-441	24	14	for	for	ADP
admet-441	24	15	drug	drug	NOUN
admet-441	24	16	transporter	transporter	NOUN
admet-441	24	17	studies	study	NOUN
admet-441	24	18	;	;	PUNCT
admet-441	24	19	however	however	ADV
admet-441	24	20	,	,	PUNCT
admet-441	24	21	there	there	PRON
admet-441	24	22	are	be	VERB
admet-441	24	23	several	several	ADJ
admet-441	24	24	pitfalls	pitfall	NOUN
admet-441	24	25	in	in	ADP
admet-441	24	26	estimating	estimate	VERB
admet-441	24	27	transporter	transporter	NOUN
admet-441	24	28	kinetics	kinetic	NOUN
admet-441	24	29	using	use	VERB
admet-441	24	30	these	these	DET
admet-441	24	31	conventional	conventional	ADJ
admet-441	24	32	approaches	approach	NOUN
admet-441	24	33	[	[	X
admet-441	24	34	16	16	NUM
admet-441	24	35	]	]	PUNCT
admet-441	24	36	.	.	PUNCT
admet-441	25	1	considering	consider	VERB
admet-441	25	2	that	that	SCONJ
admet-441	25	3	one	one	NUM
admet-441	25	4	drug	drug	NOUN
admet-441	25	5	can	can	AUX
admet-441	25	6	be	be	AUX
admet-441	25	7	transported	transport	VERB
admet-441	25	8	by	by	ADP
admet-441	25	9	more	more	ADJ
admet-441	25	10	than	than	ADP
admet-441	25	11	one	one	NUM
admet-441	25	12	uptake	uptake	ADJ
admet-441	25	13	or	or	CCONJ
admet-441	25	14	efflux	efflux	VERB
admet-441	25	15	transporter	transporter	NOUN
admet-441	25	16	,	,	PUNCT
admet-441	25	17	a	a	DET
admet-441	25	18	limitation	limitation	NOUN
admet-441	25	19	of	of	ADP
admet-441	25	20	these	these	DET
admet-441	25	21	systems	system	NOUN
admet-441	25	22	is	be	AUX
admet-441	25	23	the	the	DET
admet-441	25	24	presence	presence	NOUN
admet-441	25	25	of	of	ADP
admet-441	25	26	a	a	DET
admet-441	25	27	single	single	ADJ
admet-441	25	28	transporter	transporter	NOUN
admet-441	25	29	of	of	ADP
admet-441	25	30	interest	interest	NOUN
admet-441	25	31	.	.	PUNCT
admet-441	26	1	further	far	ADV
admet-441	26	2	,	,	PUNCT
admet-441	26	3	given	give	VERB
admet-441	26	4	that	that	SCONJ
admet-441	26	5	there	there	PRON
admet-441	26	6	exists	exist	VERB
admet-441	26	7	an	an	DET
admet-441	26	8	interplay	interplay	NOUN
admet-441	26	9	between	between	ADP
admet-441	26	10	drug	drug	NOUN
admet-441	26	11	metabolizing	metabolize	VERB
admet-441	26	12	enzymes	enzyme	NOUN
admet-441	26	13	and	and	CCONJ
admet-441	26	14	transporters	transporter	NOUN
admet-441	26	15	,	,	PUNCT
admet-441	26	16	cell	cell	NOUN
admet-441	26	17	lines	line	NOUN
admet-441	26	18	lacking	lack	VERB
admet-441	26	19	metabolism	metabolism	NOUN
admet-441	26	20	machinery	machinery	NOUN
admet-441	26	21	pose	pose	VERB
admet-441	26	22	another	another	DET
admet-441	26	23	limitation	limitation	NOUN
admet-441	26	24	to	to	ADP
admet-441	26	25	their	their	PRON
admet-441	26	26	use	use	NOUN
admet-441	26	27	.	.	PUNCT
admet-441	27	1	in	in	ADP
admet-441	27	2	vitro	vitro	X
admet-441	27	3	experiments	experiment	NOUN
admet-441	27	4	can	can	AUX
admet-441	27	5	lead	lead	VERB
admet-441	27	6	to	to	ADP
admet-441	27	7	biased	biased	ADJ
admet-441	27	8	estimation	estimation	NOUN
admet-441	27	9	of	of	ADP
admet-441	27	10	apparent	apparent	ADJ
admet-441	27	11	km	km	NOUN
admet-441	27	12	,	,	PUNCT
admet-441	27	13	the	the	DET
admet-441	27	14	biochemical	biochemical	ADJ
admet-441	27	15	constant	constant	NOUN
admet-441	27	16	in	in	ADP
admet-441	27	17	experiments	experiment	NOUN
admet-441	27	18	that	that	PRON
admet-441	27	19	assumes	assume	VERB
admet-441	27	20	similar	similar	ADJ
admet-441	27	21	km	km	NOUN
admet-441	27	22	for	for	ADP
admet-441	27	23	both	both	CCONJ
admet-441	27	24	apical	apical	ADJ
admet-441	27	25	and	and	CCONJ
admet-441	27	26	basal	basal	ADJ
admet-441	27	27	transport	transport	NOUN
admet-441	27	28	directions	direction	NOUN
admet-441	27	29	[	[	X
admet-441	27	30	17	17	NUM
admet-441	27	31	-	-	SYM
admet-441	27	32	20	20	NUM
admet-441	27	33	]	]	PUNCT
admet-441	27	34	.	.	PUNCT
admet-441	28	1	another	another	DET
admet-441	28	2	critical	critical	ADJ
admet-441	28	3	factor	factor	NOUN
admet-441	28	4	whether	whether	SCONJ
admet-441	28	5	intracellular	intracellular	ADJ
admet-441	28	6	concentrations	concentration	NOUN
admet-441	28	7	that	that	PRON
admet-441	28	8	drive	drive	VERB
admet-441	28	9	efflux	efflux	NOUN
admet-441	28	10	transport	transport	NOUN
admet-441	28	11	are	be	AUX
admet-441	28	12	accounted	account	VERB
admet-441	28	13	for	for	ADP
admet-441	28	14	[	[	X
admet-441	28	15	21	21	NUM
admet-441	28	16	]	]	PUNCT
admet-441	28	17	.	.	PUNCT
admet-441	29	1	drug	drug	NOUN
admet-441	29	2	concentrations	concentration	NOUN
admet-441	29	3	within	within	ADP
admet-441	29	4	the	the	DET
admet-441	29	5	donor	donor	NOUN
admet-441	29	6	and	and	CCONJ
admet-441	29	7	acceptor	acceptor	NOUN
admet-441	29	8	compartments	compartment	NOUN
admet-441	29	9	are	be	AUX
admet-441	29	10	dynamic	dynamic	ADJ
admet-441	29	11	;	;	PUNCT
admet-441	29	12	thus	thus	ADV
admet-441	29	13	,	,	PUNCT
admet-441	29	14	the	the	DET
admet-441	29	15	assumption	assumption	NOUN
admet-441	29	16	that	that	SCONJ
admet-441	29	17	unbound	unbound	NOUN
admet-441	29	18	drug	drug	NOUN
admet-441	29	19	concentrations	concentration	NOUN
admet-441	29	20	on	on	ADP
admet-441	29	21	either	either	DET
admet-441	29	22	side	side	NOUN
admet-441	29	23	of	of	ADP
admet-441	29	24	a	a	DET
admet-441	29	25	membrane	membrane	NOUN
admet-441	29	26	are	be	AUX
admet-441	29	27	in	in	ADP
admet-441	29	28	thermodynamic	thermodynamic	ADJ
admet-441	29	29	equilibrium	equilibrium	NOUN
admet-441	29	30	[	[	X
admet-441	29	31	22	22	NUM
admet-441	29	32	,	,	PUNCT
admet-441	29	33	23	23	NUM
admet-441	29	34	]	]	PUNCT
admet-441	29	35	is	be	AUX
admet-441	29	36	not	not	PART
admet-441	29	37	applicable	applicable	ADJ
admet-441	29	38	for	for	ADP
admet-441	29	39	drugs	drug	NOUN
admet-441	29	40	that	that	PRON
admet-441	29	41	are	be	AUX
admet-441	29	42	poorly	poorly	ADV
admet-441	29	43	permeable	permeable	ADJ
admet-441	29	44	,	,	PUNCT
admet-441	29	45	actively	actively	ADV
admet-441	29	46	transported	transport	VERB
admet-441	29	47	,	,	PUNCT
admet-441	29	48	or	or	CCONJ
admet-441	29	49	extensively	extensively	ADV
admet-441	29	50	metabolized	metabolize	VERB
admet-441	29	51	.	.	PUNCT
admet-441	30	1	a	a	DET
admet-441	30	2	host	host	NOUN
admet-441	30	3	of	of	ADP
admet-441	30	4	in	in	ADP
admet-441	30	5	vitro	vitro	X
admet-441	30	6	assays	assay	NOUN
admet-441	30	7	have	have	AUX
admet-441	30	8	been	be	AUX
admet-441	30	9	developed	develop	VERB
admet-441	30	10	to	to	PART
admet-441	30	11	mimic	mimic	VERB
admet-441	30	12	the	the	DET
admet-441	30	13	complexity	complexity	NOUN
admet-441	30	14	of	of	ADP
admet-441	30	15	biological	biological	ADJ
admet-441	30	16	systems	system	NOUN
admet-441	30	17	;	;	PUNCT
admet-441	30	18	however	however	ADV
admet-441	30	19	,	,	PUNCT
admet-441	30	20	many	many	ADJ
admet-441	30	21	questions	question	NOUN
admet-441	30	22	remain	remain	VERB
admet-441	30	23	regarding	regard	VERB
admet-441	30	24	the	the	DET
admet-441	30	25	translation	translation	NOUN
admet-441	30	26	of	of	ADP
admet-441	30	27	in	in	ADP
admet-441	30	28	vitro	vitro	X
admet-441	30	29	information	information	NOUN
admet-441	30	30	to	to	ADP
admet-441	30	31	in	in	ADP
admet-441	30	32	vivo	vivo	NOUN
admet-441	30	33	.	.	PUNCT
admet-441	31	1	therefore	therefore	ADV
admet-441	31	2	,	,	PUNCT
admet-441	31	3	in	in	ADP
admet-441	31	4	vivo	vivo	NOUN
admet-441	31	5	systems	system	NOUN
admet-441	31	6	provide	provide	VERB
admet-441	31	7	the	the	DET
admet-441	31	8	ultimate	ultimate	ADJ
admet-441	31	9	determination	determination	NOUN
admet-441	31	10	of	of	ADP
admet-441	31	11	the	the	DET
admet-441	31	12	effect	effect	NOUN
admet-441	31	13	of	of	ADP
admet-441	31	14	drug	drug	NOUN
admet-441	31	15	transporters	transporter	NOUN
admet-441	31	16	on	on	ADP
admet-441	31	17	disposition	disposition	NOUN
admet-441	31	18	of	of	ADP
admet-441	31	19	drugs	drug	NOUN
admet-441	31	20	.	.	PUNCT
admet-441	32	1	transgenic	transgenic	NOUN
admet-441	32	2	and	and	CCONJ
admet-441	32	3	mutant	mutant	ADJ
admet-441	32	4	animal	animal	NOUN
admet-441	32	5	models	model	NOUN
admet-441	32	6	have	have	AUX
admet-441	32	7	provided	provide	VERB
admet-441	32	8	an	an	DET
admet-441	32	9	important	important	ADJ
admet-441	32	10	tool	tool	NOUN
admet-441	32	11	for	for	ADP
admet-441	32	12	assessing	assess	VERB
admet-441	32	13	drug	drug	NOUN
admet-441	32	14	efflux	efflux	NOUN
admet-441	32	15	transporter	transporter	NOUN
admet-441	32	16	activity	activity	NOUN
admet-441	32	17	.	.	PUNCT
admet-441	33	1	to	to	ADP
admet-441	33	2	this	this	DET
admet-441	33	3	end	end	NOUN
admet-441	33	4	,	,	PUNCT
admet-441	33	5	the	the	DET
admet-441	33	6	efflux	efflux	NOUN
admet-441	33	7	transporters	transporter	NOUN
admet-441	33	8	p	p	NOUN
admet-441	33	9	-	-	PUNCT
admet-441	33	10	glycoprotein	glycoprotein	NOUN
admet-441	33	11	(	(	PUNCT
admet-441	33	12	p	p	NOUN
admet-441	33	13	-	-	PUNCT
admet-441	33	14	gp	gp	NOUN
admet-441	33	15	)	)	PUNCT
admet-441	33	16	and	and	CCONJ
admet-441	33	17	multidrug	multidrug	VERB
admet-441	33	18	resistanceassociated	resistanceassociate	VERB
admet-441	33	19	protein	protein	NOUN
admet-441	33	20	(	(	PUNCT
admet-441	33	21	mrp1	mrp1	PROPN
admet-441	33	22	)	)	PUNCT
admet-441	33	23	have	have	AUX
admet-441	33	24	been	be	AUX
admet-441	33	25	the	the	DET
admet-441	33	26	most	most	ADV
admet-441	33	27	frequently	frequently	ADV
admet-441	33	28	investigated	investigate	VERB
admet-441	33	29	in	in	ADP
admet-441	33	30	transgenic	transgenic	NOUN
admet-441	33	31	animals	animal	NOUN
admet-441	33	32	[	[	PUNCT
admet-441	33	33	24	24	NUM
admet-441	33	34	-	-	SYM
admet-441	33	35	26	26	NUM
admet-441	33	36	]	]	PUNCT
admet-441	33	37	.	.	PUNCT
admet-441	34	1	like	like	INTJ
admet-441	34	2	in	in	ADP
admet-441	34	3	vitro	vitro	X
admet-441	34	4	systems	system	NOUN
admet-441	34	5	,	,	PUNCT
admet-441	34	6	in	in	ADP
admet-441	34	7	vivo	vivo	NOUN
admet-441	34	8	systems	system	NOUN
admet-441	34	9	also	also	ADV
admet-441	34	10	have	have	VERB
admet-441	34	11	limitations	limitation	NOUN
admet-441	34	12	.	.	PUNCT
admet-441	35	1	mice	mouse	NOUN
admet-441	35	2	generally	generally	ADV
admet-441	35	3	have	have	VERB
admet-441	35	4	two	two	NUM
admet-441	35	5	genes	gene	NOUN
admet-441	35	6	to	to	PART
admet-441	35	7	encode	encode	VERB
admet-441	35	8	transporter	transporter	NOUN
admet-441	35	9	proteins	protein	NOUN
admet-441	35	10	,	,	PUNCT
admet-441	35	11	and	and	CCONJ
admet-441	35	12	silencing	silence	VERB
admet-441	35	13	one	one	NUM
admet-441	35	14	of	of	ADP
admet-441	35	15	these	these	DET
admet-441	35	16	genes	gene	NOUN
admet-441	35	17	may	may	AUX
admet-441	35	18	not	not	PART
admet-441	35	19	sufficiently	sufficiently	ADV
admet-441	35	20	suppress	suppress	VERB
admet-441	35	21	the	the	DET
admet-441	35	22	expression	expression	NOUN
admet-441	35	23	of	of	ADP
admet-441	35	24	the	the	DET
admet-441	35	25	protein	protein	NOUN
admet-441	35	26	[	[	X
admet-441	35	27	25	25	NUM
admet-441	35	28	]	]	PUNCT
admet-441	35	29	.	.	PUNCT
admet-441	36	1	moreover	moreover	ADV
admet-441	36	2	,	,	PUNCT
admet-441	36	3	efflux	efflux	NOUN
admet-441	36	4	transporters	transporter	NOUN
admet-441	36	5	may	may	AUX
admet-441	36	6	work	work	VERB
admet-441	36	7	through	through	ADP
admet-441	36	8	a	a	DET
admet-441	36	9	compensatory	compensatory	ADJ
admet-441	36	10	mechanism	mechanism	NOUN
admet-441	36	11	,	,	PUNCT
admet-441	36	12	where	where	SCONJ
admet-441	36	13	absence	absence	NOUN
admet-441	36	14	of	of	ADP
admet-441	36	15	one	one	NUM
admet-441	36	16	gene	gene	NOUN
admet-441	36	17	might	might	AUX
admet-441	36	18	be	be	AUX
admet-441	36	19	compensated	compensate	VERB
admet-441	36	20	for	for	ADP
admet-441	36	21	by	by	ADP
admet-441	36	22	another	another	DET
admet-441	36	23	transporter	transporter	NOUN
admet-441	36	24	gene	gene	NOUN
admet-441	36	25	[	[	X
admet-441	36	26	27	27	NUM
admet-441	36	27	]	]	PUNCT
admet-441	36	28	.	.	PUNCT
admet-441	37	1	furthermore	furthermore	ADV
admet-441	37	2	,	,	PUNCT
admet-441	37	3	due	due	ADP
admet-441	37	4	to	to	ADP
admet-441	37	5	the	the	DET
admet-441	37	6	ubiquitous	ubiquitous	ADJ
admet-441	37	7	expression	expression	NOUN
admet-441	37	8	of	of	ADP
admet-441	37	9	drug	drug	NOUN
admet-441	37	10	efflux	efflux	NOUN
admet-441	37	11	transporters	transporter	NOUN
admet-441	37	12	throughout	throughout	ADP
admet-441	37	13	the	the	DET
admet-441	37	14	body	body	NOUN
admet-441	37	15	,	,	PUNCT
admet-441	37	16	the	the	DET
admet-441	37	17	removal	removal	NOUN
admet-441	37	18	of	of	ADP
admet-441	37	19	a	a	DET
admet-441	37	20	gene	gene	NOUN
admet-441	37	21	or	or	CCONJ
admet-441	37	22	genes	gene	NOUN
admet-441	37	23	affects	affect	VERB
admet-441	37	24	tissues	tissue	NOUN
admet-441	37	25	other	other	ADJ
admet-441	37	26	than	than	ADP
admet-441	37	27	the	the	DET
admet-441	37	28	organ	organ	NOUN
admet-441	37	29	of	of	ADP
admet-441	37	30	interest	interest	NOUN
admet-441	37	31	.	.	PUNCT
admet-441	38	1	this	this	PRON
admet-441	38	2	can	can	AUX
admet-441	38	3	lead	lead	VERB
admet-441	38	4	to	to	ADP
admet-441	38	5	undesirable	undesirable	ADJ
admet-441	38	6	outcomes	outcome	NOUN
admet-441	38	7	such	such	ADJ
admet-441	38	8	as	as	ADP
admet-441	38	9	altered	alter	VERB
admet-441	38	10	pharmacokinetics	pharmacokinetic	NOUN
admet-441	38	11	,	,	PUNCT
admet-441	38	12	lack	lack	NOUN
admet-441	38	13	of	of	ADP
admet-441	38	14	viability	viability	NOUN
admet-441	38	15	,	,	PUNCT
admet-441	38	16	or	or	CCONJ
admet-441	38	17	systemic	systemic	ADJ
admet-441	38	18	toxicity	toxicity	NOUN
admet-441	38	19	.	.	PUNCT
admet-441	39	1	to	to	PART
admet-441	39	2	get	get	VERB
admet-441	39	3	around	around	ADP
admet-441	39	4	these	these	DET
admet-441	39	5	limitations	limitation	NOUN
admet-441	39	6	,	,	PUNCT
admet-441	39	7	specific	specific	ADJ
admet-441	39	8	transporters	transporter	NOUN
admet-441	39	9	can	can	AUX
admet-441	39	10	be	be	AUX
admet-441	39	11	modulated	modulate	VERB
admet-441	39	12	with	with	ADP
admet-441	39	13	various	various	ADJ
admet-441	39	14	agents	agent	NOUN
admet-441	39	15	[	[	X
admet-441	39	16	28	28	NUM
admet-441	39	17	]	]	PUNCT
admet-441	39	18	.	.	PUNCT
admet-441	40	1	the	the	DET
admet-441	40	2	advantage	advantage	NOUN
admet-441	40	3	of	of	ADP
admet-441	40	4	using	use	VERB
admet-441	40	5	drug	drug	NOUN
admet-441	40	6	transporter	transporter	NOUN
admet-441	40	7	modulators	modulator	NOUN
admet-441	40	8	is	be	AUX
admet-441	40	9	that	that	SCONJ
admet-441	40	10	these	these	DET
admet-441	40	11	studies	study	NOUN
admet-441	40	12	are	be	AUX
admet-441	40	13	generally	generally	ADV
admet-441	40	14	performed	perform	VERB
admet-441	40	15	with	with	ADP
admet-441	40	16	wild	wild	ADJ
admet-441	40	17	-	-	PUNCT
admet-441	40	18	type	type	NOUN
admet-441	40	19	animals	animal	NOUN
admet-441	40	20	,	,	PUNCT
admet-441	40	21	and	and	CCONJ
admet-441	40	22	thus	thus	ADV
admet-441	40	23	,	,	PUNCT
admet-441	40	24	the	the	DET
admet-441	40	25	effect	effect	NOUN
admet-441	40	26	of	of	ADP
admet-441	40	27	a	a	DET
admet-441	40	28	compensatory	compensatory	ADJ
admet-441	40	29	mechanism	mechanism	NOUN
admet-441	40	30	admet	admet	X
admet-441	40	31	&	&	CCONJ
admet-441	40	32	dmpk	dmpk	PROPN
admet-441	40	33	5(4	5(4	NOUN
admet-441	40	34	)	)	PUNCT
admet-441	40	35	(	(	PUNCT
admet-441	40	36	2017	2017	NUM
admet-441	40	37	)	)	PUNCT
admet-441	40	38	201	201	NUM
admet-441	40	39	-	-	SYM
admet-441	40	40	211	211	NUM
admet-441	40	41	utilizing	utilize	VERB
admet-441	40	42	in	in	ADP
admet-441	40	43	vitro	vitro	X
admet-441	40	44	transporter	transporter	NOUN
admet-441	40	45	data	datum	NOUN
admet-441	40	46	in	in	ADP
admet-441	40	47	ivive	ivive	ADJ
admet-441	40	48	-	-	PUNCT
admet-441	40	49	pbpk	pbpk	ADJ
admet-441	40	50	doi	doi	NOUN
admet-441	40	51	:	:	PUNCT
admet-441	40	52	10.5599	10.5599	NUM
admet-441	40	53	/	/	SYM
admet-441	40	54	admet.5.4.441	admet.5.4.441	NUM
admet-441	40	55	203	203	NUM
admet-441	40	56	is	be	AUX
admet-441	40	57	not	not	PART
admet-441	40	58	so	so	ADV
admet-441	40	59	important	important	ADJ
admet-441	40	60	.	.	PUNCT
admet-441	41	1	however	however	ADV
admet-441	41	2	,	,	PUNCT
admet-441	41	3	due	due	ADP
admet-441	41	4	to	to	PART
admet-441	41	5	overlap	overlap	NOUN
admet-441	41	6	in	in	ADP
admet-441	41	7	substrate	substrate	NOUN
admet-441	41	8	specificities	specificity	NOUN
admet-441	41	9	,	,	PUNCT
admet-441	41	10	and	and	CCONJ
admet-441	41	11	lack	lack	NOUN
admet-441	41	12	of	of	ADP
admet-441	41	13	specificity	specificity	NOUN
admet-441	41	14	,	,	PUNCT
admet-441	41	15	drug	drug	NOUN
admet-441	41	16	efflux	efflux	NOUN
admet-441	41	17	transporter	transporter	NOUN
admet-441	41	18	modulation	modulation	NOUN
admet-441	41	19	is	be	AUX
admet-441	41	20	not	not	PART
admet-441	41	21	as	as	ADV
admet-441	41	22	effective	effective	ADJ
admet-441	41	23	as	as	ADP
admet-441	41	24	gene	gene	NOUN
admet-441	41	25	knockout	knockout	NOUN
admet-441	41	26	models	model	NOUN
admet-441	41	27	[	[	X
admet-441	41	28	28	28	NUM
admet-441	41	29	]	]	PUNCT
admet-441	41	30	.	.	PUNCT
admet-441	42	1	further	far	ADV
admet-441	42	2	,	,	PUNCT
admet-441	42	3	if	if	SCONJ
admet-441	42	4	drug	drug	NOUN
admet-441	42	5	transporter	transporter	NOUN
admet-441	42	6	modulators	modulator	NOUN
admet-441	42	7	are	be	AUX
admet-441	42	8	dosed	dose	VERB
admet-441	42	9	orally	orally	ADV
admet-441	42	10	,	,	PUNCT
admet-441	42	11	it	it	PRON
admet-441	42	12	is	be	AUX
admet-441	42	13	often	often	ADV
admet-441	42	14	difficult	difficult	ADJ
admet-441	42	15	to	to	PART
admet-441	42	16	get	get	VERB
admet-441	42	17	an	an	DET
admet-441	42	18	effective	effective	ADJ
admet-441	42	19	dose	dose	NOUN
admet-441	42	20	to	to	ADP
admet-441	42	21	the	the	DET
admet-441	42	22	targeted	target	VERB
admet-441	42	23	organ	organ	NOUN
admet-441	42	24	;	;	PUNCT
admet-441	42	25	this	this	PRON
admet-441	42	26	is	be	AUX
admet-441	42	27	likely	likely	ADV
admet-441	42	28	be	be	AUX
admet-441	42	29	due	due	ADJ
admet-441	42	30	to	to	PART
admet-441	42	31	first	first	ADV
admet-441	42	32	pass	pass	VERB
admet-441	42	33	metabolism	metabolism	NOUN
admet-441	42	34	.	.	PUNCT
admet-441	43	1	even	even	ADV
admet-441	43	2	with	with	ADP
admet-441	43	3	intraperitoneal	intraperitoneal	ADJ
admet-441	43	4	dosing	dosing	NOUN
admet-441	43	5	,	,	PUNCT
admet-441	43	6	the	the	DET
admet-441	43	7	limited	limited	ADJ
admet-441	43	8	effective	effective	ADJ
admet-441	43	9	dose	dose	NOUN
admet-441	43	10	of	of	ADP
admet-441	43	11	the	the	DET
admet-441	43	12	modulator	modulator	NOUN
admet-441	43	13	could	could	AUX
admet-441	43	14	be	be	AUX
admet-441	43	15	because	because	SCONJ
admet-441	43	16	of	of	ADP
admet-441	43	17	physiochemical	physiochemical	ADJ
admet-441	43	18	properties	property	NOUN
admet-441	43	19	of	of	ADP
admet-441	43	20	the	the	DET
admet-441	43	21	modulator	modulator	NOUN
admet-441	43	22	,	,	PUNCT
admet-441	43	23	such	such	ADJ
admet-441	43	24	as	as	ADP
admet-441	43	25	protein	protein	NOUN
admet-441	43	26	binding	bind	VERB
admet-441	43	27	and/or	and/or	CCONJ
admet-441	43	28	unfavorable	unfavorable	ADJ
admet-441	43	29	tissue	tissue	NOUN
admet-441	43	30	distribution	distribution	NOUN
admet-441	43	31	[	[	X
admet-441	43	32	29	29	NUM
admet-441	43	33	]	]	PUNCT
admet-441	43	34	.	.	PUNCT
admet-441	44	1	importantly	importantly	ADV
admet-441	44	2	,	,	PUNCT
admet-441	44	3	the	the	DET
admet-441	44	4	effects	effect	NOUN
admet-441	44	5	of	of	ADP
admet-441	44	6	modulators	modulator	NOUN
admet-441	44	7	on	on	ADP
admet-441	44	8	drug	drug	NOUN
admet-441	44	9	transporters	transporter	NOUN
admet-441	44	10	are	be	AUX
admet-441	44	11	transient	transient	ADJ
admet-441	44	12	and	and	CCONJ
admet-441	44	13	concentration	concentration	NOUN
admet-441	44	14	dependent	dependent	ADJ
admet-441	44	15	;	;	PUNCT
admet-441	44	16	therefore	therefore	ADV
admet-441	44	17	,	,	PUNCT
admet-441	44	18	proper	proper	ADJ
admet-441	44	19	dosing	dosing	NOUN
admet-441	44	20	and	and	CCONJ
admet-441	44	21	study	study	NOUN
admet-441	44	22	time	time	NOUN
admet-441	44	23	points	point	NOUN
admet-441	44	24	becomes	become	VERB
admet-441	44	25	critical	critical	ADJ
admet-441	44	26	variables	variable	NOUN
admet-441	44	27	in	in	ADP
admet-441	44	28	these	these	DET
admet-441	44	29	studies	study	NOUN
admet-441	44	30	.	.	PUNCT
admet-441	45	1	there	there	PRON
admet-441	45	2	exists	exist	VERB
admet-441	45	3	potential	potential	ADJ
admet-441	45	4	species	specie	NOUN
admet-441	45	5	-	-	PUNCT
admet-441	45	6	specific	specific	ADJ
admet-441	45	7	differences	difference	NOUN
admet-441	45	8	in	in	ADP
admet-441	45	9	drug	drug	NOUN
admet-441	45	10	transporter	transporter	NOUN
admet-441	45	11	activities	activity	NOUN
admet-441	45	12	and	and	CCONJ
admet-441	45	13	contributions	contribution	NOUN
admet-441	45	14	,	,	PUNCT
admet-441	45	15	as	as	SCONJ
admet-441	45	16	exhibited	exhibit	VERB
admet-441	45	17	in	in	ADP
admet-441	45	18	mdr1	mdr1	PROPN
admet-441	45	19	functional	functional	ADJ
admet-441	45	20	studies	study	NOUN
admet-441	45	21	,	,	PUNCT
admet-441	45	22	in	in	ADP
admet-441	45	23	which	which	PRON
admet-441	45	24	some	some	DET
admet-441	45	25	compounds	compound	NOUN
admet-441	45	26	showed	show	VERB
admet-441	45	27	affinity	affinity	NOUN
admet-441	45	28	for	for	ADP
admet-441	45	29	mdr1a	mdr1a	PROPN
admet-441	45	30	/	/	SYM
admet-441	45	31	b	b	NOUN
admet-441	45	32	activity	activity	NOUN
admet-441	45	33	in	in	ADP
admet-441	45	34	mouse	mouse	NOUN
admet-441	45	35	mdr1	mdr1	PROPN
admet-441	45	36	cells	cell	NOUN
admet-441	45	37	but	but	CCONJ
admet-441	45	38	not	not	PART
admet-441	45	39	in	in	ADP
admet-441	45	40	human	human	ADJ
admet-441	45	41	cells	cell	NOUN
admet-441	45	42	[	[	X
admet-441	45	43	30	30	NUM
admet-441	45	44	]	]	PUNCT
admet-441	45	45	.	.	PUNCT
admet-441	46	1	currently	currently	ADV
admet-441	46	2	available	available	ADJ
admet-441	46	3	in	in	ADP
admet-441	46	4	vitro	vitro	X
admet-441	46	5	and	and	CCONJ
admet-441	46	6	in	in	ADP
admet-441	46	7	vivo	vivo	NOUN
admet-441	46	8	models	model	NOUN
admet-441	46	9	have	have	VERB
admet-441	46	10	a	a	DET
admet-441	46	11	limited	limited	ADJ
admet-441	46	12	capability	capability	NOUN
admet-441	46	13	to	to	PART
admet-441	46	14	quantitatively	quantitatively	ADV
admet-441	46	15	predict	predict	VERB
admet-441	46	16	the	the	DET
admet-441	46	17	impact	impact	NOUN
admet-441	46	18	of	of	ADP
admet-441	46	19	transporters	transporter	NOUN
admet-441	46	20	on	on	ADP
admet-441	46	21	intracellular	intracellular	ADJ
admet-441	46	22	drug	drug	NOUN
admet-441	46	23	concentrations	concentration	NOUN
admet-441	46	24	.	.	PUNCT
admet-441	47	1	as	as	SCONJ
admet-441	47	2	pbpk	pbpk	NOUN
admet-441	47	3	modeling	modeling	NOUN
admet-441	47	4	approaches	approach	NOUN
admet-441	47	5	consider	consider	VERB
admet-441	47	6	physicochemical	physicochemical	ADJ
admet-441	47	7	properties	property	NOUN
admet-441	47	8	of	of	ADP
admet-441	47	9	drugs	drug	NOUN
admet-441	47	10	,	,	PUNCT
admet-441	47	11	in	in	ADP
admet-441	47	12	vitro	vitro	X
admet-441	47	13	cell	cell	NOUN
admet-441	47	14	-	-	PUNCT
admet-441	47	15	based	base	VERB
admet-441	47	16	passive	passive	ADJ
admet-441	47	17	permeability	permeability	NOUN
admet-441	47	18	,	,	PUNCT
admet-441	47	19	and	and	CCONJ
admet-441	47	20	cellular	cellular	ADJ
admet-441	47	21	uptake	uptake	NOUN
admet-441	47	22	/	/	SYM
admet-441	47	23	efflux	efflux	NOUN
admet-441	47	24	,	,	PUNCT
admet-441	47	25	as	as	ADV
admet-441	47	26	well	well	ADV
admet-441	47	27	as	as	ADP
admet-441	47	28	in	in	ADP
admet-441	47	29	vivo	vivo	NOUN
admet-441	47	30	animal	animal	NOUN
admet-441	47	31	and	and	CCONJ
admet-441	47	32	human	human	ADJ
admet-441	47	33	pharmacokinetic	pharmacokinetic	ADJ
admet-441	47	34	data	datum	NOUN
admet-441	47	35	to	to	PART
admet-441	47	36	estimate	estimate	VERB
admet-441	47	37	unbound	unbound	NOUN
admet-441	47	38	intracellular	intracellular	ADJ
admet-441	47	39	drug	drug	NOUN
admet-441	47	40	concentrations	concentration	NOUN
admet-441	47	41	in	in	ADP
admet-441	47	42	different	different	ADJ
admet-441	47	43	tissues	tissue	NOUN
admet-441	47	44	,	,	PUNCT
admet-441	47	45	this	this	DET
admet-441	47	46	approach	approach	NOUN
admet-441	47	47	provides	provide	VERB
admet-441	47	48	an	an	DET
admet-441	47	49	effective	effective	ADJ
admet-441	47	50	platform	platform	NOUN
admet-441	47	51	over	over	ADP
admet-441	47	52	currently	currently	ADV
admet-441	47	53	available	available	ADJ
admet-441	47	54	in	in	ADP
admet-441	47	55	vitro	vitro	X
admet-441	47	56	and	and	CCONJ
admet-441	47	57	in	in	ADP
admet-441	47	58	vivo	vivo	NOUN
admet-441	47	59	models	model	NOUN
admet-441	47	60	.	.	PUNCT
admet-441	48	1	however	however	ADV
admet-441	48	2	,	,	PUNCT
admet-441	48	3	these	these	DET
admet-441	48	4	models	model	NOUN
admet-441	48	5	involve	involve	VERB
admet-441	48	6	a	a	DET
admet-441	48	7	number	number	NOUN
admet-441	48	8	of	of	ADP
admet-441	48	9	assumptions	assumption	NOUN
admet-441	48	10	.	.	PUNCT
admet-441	49	1	use	use	NOUN
admet-441	49	2	of	of	ADP
admet-441	49	3	in	in	ADP
admet-441	49	4	vitro	vitro	X
admet-441	49	5	models	model	NOUN
admet-441	49	6	,	,	PUNCT
admet-441	49	7	such	such	ADJ
admet-441	49	8	as	as	ADP
admet-441	49	9	three	three	NUM
admet-441	49	10	-	-	PUNCT
admet-441	49	11	dimensional	dimensional	ADJ
admet-441	49	12	cultured	cultured	ADJ
admet-441	49	13	-	-	PUNCT
admet-441	49	14	hepatocytes	hepatocyte	NOUN
admet-441	49	15	that	that	PRON
admet-441	49	16	retain	retain	VERB
admet-441	49	17	the	the	DET
admet-441	49	18	activity	activity	NOUN
admet-441	49	19	of	of	ADP
admet-441	49	20	both	both	CCONJ
admet-441	49	21	apical	apical	ADJ
admet-441	49	22	and	and	CCONJ
admet-441	49	23	basolateral	basolateral	ADJ
admet-441	49	24	hepatic	hepatic	ADJ
admet-441	49	25	drug	drug	NOUN
admet-441	49	26	transporters	transporter	NOUN
admet-441	49	27	,	,	PUNCT
admet-441	49	28	drug	drug	NOUN
admet-441	49	29	metabolizing	metabolize	VERB
admet-441	49	30	enzymes	enzyme	NOUN
admet-441	49	31	,	,	PUNCT
admet-441	49	32	or	or	CCONJ
admet-441	49	33	in	in	ADP
admet-441	49	34	vivo	vivo	ADJ
admet-441	49	35	multiple	multiple	ADJ
admet-441	49	36	gene	gene	NOUN
admet-441	49	37	/	/	SYM
admet-441	49	38	tissue	tissue	NOUN
admet-441	49	39	-	-	PUNCT
admet-441	49	40	selective	selective	ADJ
admet-441	49	41	knockouts	knockout	NOUN
admet-441	49	42	,	,	PUNCT
admet-441	49	43	serves	serve	VERB
admet-441	49	44	as	as	ADP
admet-441	49	45	an	an	DET
admet-441	49	46	improved	improved	ADJ
admet-441	49	47	medium	medium	NOUN
admet-441	49	48	to	to	PART
admet-441	49	49	bolster	bolster	VERB
admet-441	49	50	refinement	refinement	NOUN
admet-441	49	51	of	of	ADP
admet-441	49	52	pbpk	pbpk	NOUN
admet-441	49	53	models	model	NOUN
admet-441	49	54	for	for	ADP
admet-441	49	55	better	well	ADJ
admet-441	49	56	prediction	prediction	NOUN
admet-441	49	57	in	in	ADP
admet-441	49	58	humans	human	NOUN
admet-441	49	59	.	.	PUNCT
admet-441	50	1	ivive	ivive	ADJ
admet-441	50	2	-	-	PUNCT
admet-441	50	3	pbpk	pbpk	ADJ
admet-441	50	4	pbpk	pbpk	NOUN
admet-441	50	5	models	model	NOUN
admet-441	50	6	offer	offer	VERB
admet-441	50	7	a	a	DET
admet-441	50	8	quantitative	quantitative	ADJ
admet-441	50	9	mechanistic	mechanistic	ADJ
admet-441	50	10	platform	platform	NOUN
admet-441	50	11	for	for	ADP
admet-441	50	12	predicting	predict	VERB
admet-441	50	13	drug	drug	NOUN
admet-441	50	14	pharmacokinetics	pharmacokinetic	NOUN
admet-441	50	15	.	.	PUNCT
admet-441	51	1	when	when	SCONJ
admet-441	51	2	modeled	model	VERB
admet-441	51	3	for	for	ADP
admet-441	51	4	pharmacodynamics	pharmacodynamic	NOUN
admet-441	51	5	,	,	PUNCT
admet-441	51	6	these	these	DET
admet-441	51	7	models	model	NOUN
admet-441	51	8	can	can	AUX
admet-441	51	9	be	be	AUX
admet-441	51	10	used	use	VERB
admet-441	51	11	to	to	PART
admet-441	51	12	predict	predict	VERB
admet-441	51	13	clinical	clinical	ADJ
admet-441	51	14	efficacy	efficacy	NOUN
admet-441	51	15	and	and	CCONJ
admet-441	51	16	safety	safety	NOUN
admet-441	51	17	with	with	ADP
admet-441	51	18	varying	vary	VERB
admet-441	51	19	drug	drug	NOUN
admet-441	51	20	doses	dose	NOUN
admet-441	51	21	.	.	PUNCT
admet-441	52	1	the	the	DET
admet-441	52	2	ivive	ivive	ADJ
admet-441	52	3	approach	approach	NOUN
admet-441	52	4	is	be	AUX
admet-441	52	5	well	well	ADV
admet-441	52	6	established	establish	VERB
admet-441	52	7	for	for	ADP
admet-441	52	8	many	many	ADJ
admet-441	52	9	drug	drug	NOUN
admet-441	52	10	metabolizing	metabolize	VERB
admet-441	52	11	enzymes	enzyme	NOUN
admet-441	52	12	[	[	X
admet-441	52	13	31	31	NUM
admet-441	52	14	,	,	PUNCT
admet-441	52	15	32	32	NUM
admet-441	52	16	]	]	PUNCT
admet-441	52	17	;	;	PUNCT
admet-441	52	18	however	however	ADV
admet-441	52	19	,	,	PUNCT
admet-441	52	20	the	the	DET
admet-441	52	21	integration	integration	NOUN
admet-441	52	22	of	of	ADP
admet-441	52	23	drug	drug	NOUN
admet-441	52	24	transporters	transporter	NOUN
admet-441	52	25	into	into	ADP
admet-441	52	26	pbpk	pbpk	ADJ
admet-441	52	27	models	model	NOUN
admet-441	52	28	is	be	AUX
admet-441	52	29	lacking	lack	VERB
admet-441	52	30	,	,	PUNCT
admet-441	52	31	with	with	SCONJ
admet-441	52	32	few	few	ADJ
admet-441	52	33	positive	positive	ADJ
admet-441	52	34	examples	example	NOUN
admet-441	52	35	reported	report	VERB
admet-441	52	36	[	[	X
admet-441	52	37	33	33	NUM
admet-441	52	38	-	-	SYM
admet-441	52	39	36	36	NUM
admet-441	52	40	]	]	PUNCT
admet-441	52	41	.	.	PUNCT
admet-441	53	1	ivive	ivive	ADJ
admet-441	53	2	-	-	PUNCT
admet-441	53	3	pbpk	pbpk	ADJ
admet-441	53	4	models	model	NOUN
admet-441	53	5	link	link	VERB
admet-441	53	6	in	in	ADP
admet-441	53	7	vitro	vitro	X
admet-441	53	8	systems	system	NOUN
admet-441	53	9	to	to	ADP
admet-441	53	10	the	the	DET
admet-441	53	11	in	in	ADP
admet-441	53	12	vivo	vivo	NOUN
admet-441	53	13	system	system	NOUN
admet-441	53	14	through	through	ADP
admet-441	53	15	algorithms	algorithms	NOUN
admet-441	53	16	and	and	CCONJ
admet-441	53	17	scaling	scale	VERB
admet-441	53	18	factors	factor	NOUN
admet-441	53	19	[	[	X
admet-441	53	20	37	37	NUM
admet-441	53	21	,	,	PUNCT
admet-441	53	22	38	38	NUM
admet-441	53	23	]	]	PUNCT
admet-441	53	24	.	.	PUNCT
admet-441	54	1	therefore	therefore	ADV
admet-441	54	2	,	,	PUNCT
admet-441	54	3	for	for	ADP
admet-441	54	4	an	an	DET
admet-441	54	5	effective	effective	ADJ
admet-441	54	6	ivive	ivive	ADJ
admet-441	54	7	-	-	PUNCT
admet-441	54	8	pbpk	pbpk	ADJ
admet-441	54	9	model	model	NOUN
admet-441	54	10	to	to	PART
admet-441	54	11	predict	predict	VERB
admet-441	54	12	the	the	DET
admet-441	54	13	behavior	behavior	NOUN
admet-441	54	14	of	of	ADP
admet-441	54	15	a	a	DET
admet-441	54	16	drug	drug	NOUN
admet-441	54	17	in	in	ADP
admet-441	54	18	vivo	vivo	NOUN
admet-441	54	19	,	,	PUNCT
admet-441	54	20	accurate	accurate	ADJ
admet-441	54	21	and	and	CCONJ
admet-441	54	22	relevant	relevant	ADJ
admet-441	54	23	in	in	ADP
admet-441	54	24	vitro	vitro	X
admet-441	54	25	data	datum	NOUN
admet-441	54	26	in	in	ADP
admet-441	54	27	conjunction	conjunction	NOUN
admet-441	54	28	with	with	ADP
admet-441	54	29	the	the	DET
admet-441	54	30	model	model	NOUN
admet-441	54	31	system	system	NOUN
admet-441	54	32	parameters	parameter	NOUN
admet-441	54	33	of	of	ADP
admet-441	54	34	passive	passive	ADJ
admet-441	54	35	permeability	permeability	NOUN
admet-441	54	36	and	and	CCONJ
admet-441	54	37	transporter	transporter	NOUN
admet-441	54	38	-	-	PUNCT
admet-441	54	39	mediated	mediate	VERB
admet-441	54	40	flux	flux	NOUN
admet-441	54	41	are	be	AUX
admet-441	54	42	necessary	necessary	ADJ
admet-441	54	43	.	.	PUNCT
admet-441	55	1	static	static	ADJ
admet-441	55	2	models	model	NOUN
admet-441	55	3	used	use	VERB
admet-441	55	4	alongside	alongside	ADP
admet-441	55	5	pbpk	pbpk	ADJ
admet-441	55	6	models	model	NOUN
admet-441	55	7	in	in	ADP
admet-441	55	8	drug	drug	NOUN
admet-441	55	9	development	development	NOUN
admet-441	55	10	are	be	AUX
admet-441	55	11	simple	simple	ADJ
admet-441	55	12	and	and	CCONJ
admet-441	55	13	require	require	VERB
admet-441	55	14	limited	limited	ADJ
admet-441	55	15	input	input	NOUN
admet-441	55	16	data	datum	NOUN
admet-441	55	17	;	;	PUNCT
admet-441	55	18	however	however	ADV
admet-441	55	19	,	,	PUNCT
admet-441	55	20	due	due	ADP
admet-441	55	21	to	to	ADP
admet-441	55	22	simplification	simplification	NOUN
admet-441	55	23	,	,	PUNCT
admet-441	55	24	these	these	PRON
admet-441	55	25	often	often	ADV
admet-441	55	26	result	result	VERB
admet-441	55	27	in	in	ADP
admet-441	55	28	conservative	conservative	ADJ
admet-441	55	29	estimates	estimate	NOUN
admet-441	55	30	,	,	PUNCT
admet-441	55	31	a	a	DET
admet-441	55	32	lack	lack	NOUN
admet-441	55	33	of	of	ADP
admet-441	55	34	ability	ability	NOUN
admet-441	55	35	to	to	PART
admet-441	55	36	capture	capture	VERB
admet-441	55	37	parallel	parallel	ADJ
admet-441	55	38	clearance	clearance	NOUN
admet-441	55	39	and	and	CCONJ
admet-441	55	40	elimination	elimination	NOUN
admet-441	55	41	pathways	pathway	NOUN
admet-441	55	42	,	,	PUNCT
admet-441	55	43	are	be	AUX
admet-441	55	44	not	not	PART
admet-441	55	45	suitable	suitable	ADJ
admet-441	55	46	for	for	ADP
admet-441	55	47	non	non	ADJ
admet-441	55	48	-	-	ADJ
admet-441	55	49	linear	linear	ADJ
admet-441	55	50	kinetics	kinetic	NOUN
admet-441	55	51	,	,	PUNCT
admet-441	55	52	and	and	CCONJ
admet-441	55	53	lack	lack	VERB
admet-441	55	54	physiology	physiology	NOUN
admet-441	55	55	inputs	input	NOUN
admet-441	55	56	.	.	PUNCT
admet-441	56	1	although	although	SCONJ
admet-441	56	2	pbpk	pbpk	NOUN
admet-441	56	3	models	model	NOUN
admet-441	56	4	require	require	VERB
admet-441	56	5	extensive	extensive	ADJ
admet-441	56	6	in	in	ADP
admet-441	56	7	vitro	vitro	X
admet-441	56	8	and	and	CCONJ
admet-441	56	9	in	in	ADP
admet-441	56	10	vivo	vivo	ADJ
admet-441	56	11	data	datum	NOUN
admet-441	56	12	,	,	PUNCT
admet-441	56	13	they	they	PRON
admet-441	56	14	can	can	AUX
admet-441	56	15	capture	capture	VERB
admet-441	56	16	transporter	transporter	NOUN
admet-441	56	17	-	-	PUNCT
admet-441	56	18	mediated	mediate	VERB
admet-441	56	19	disposition	disposition	NOUN
admet-441	56	20	,	,	PUNCT
admet-441	56	21	describe	describe	VERB
admet-441	56	22	physiology	physiology	NOUN
admet-441	56	23	,	,	PUNCT
admet-441	56	24	and	and	CCONJ
admet-441	56	25	can	can	AUX
admet-441	56	26	be	be	AUX
admet-441	56	27	applied	apply	VERB
admet-441	56	28	for	for	ADP
admet-441	56	29	special	special	ADJ
admet-441	56	30	populations	population	NOUN
admet-441	56	31	such	such	ADJ
admet-441	56	32	as	as	ADP
admet-441	56	33	pediatric	pediatric	ADJ
admet-441	56	34	patients	patient	NOUN
admet-441	56	35	,	,	PUNCT
admet-441	56	36	in	in	ADP
admet-441	56	37	which	which	PRON
admet-441	56	38	data	datum	NOUN
admet-441	56	39	is	be	AUX
admet-441	56	40	generally	generally	ADV
admet-441	56	41	very	very	ADV
admet-441	56	42	limited	limited	ADJ
admet-441	56	43	.	.	PUNCT
admet-441	57	1	pbpk	pbpk	NOUN
admet-441	57	2	for	for	ADP
admet-441	57	3	the	the	DET
admet-441	57	4	prediction	prediction	NOUN
admet-441	57	5	of	of	ADP
admet-441	57	6	transporter	transporter	NOUN
admet-441	57	7	-	-	PUNCT
admet-441	57	8	mediated	mediate	VERB
admet-441	57	9	drug	drug	NOUN
admet-441	57	10	induced	induce	VERB
admet-441	57	11	liver	liver	NOUN
admet-441	57	12	toxicity	toxicity	NOUN
admet-441	57	13	membrane	membrane	NOUN
admet-441	57	14	transporters	transporter	NOUN
admet-441	57	15	expressed	express	VERB
admet-441	57	16	on	on	ADP
admet-441	57	17	hepatocytes	hepatocyte	NOUN
admet-441	57	18	and	and	CCONJ
admet-441	57	19	enterocytes	enterocyte	NOUN
admet-441	57	20	play	play	VERB
admet-441	57	21	a	a	DET
admet-441	57	22	critical	critical	ADJ
admet-441	57	23	role	role	NOUN
admet-441	57	24	in	in	ADP
admet-441	57	25	homeostasis	homeostasis	NOUN
admet-441	57	26	of	of	ADP
admet-441	57	27	endobiotics	endobiotic	NOUN
admet-441	57	28	,	,	PUNCT
admet-441	57	29	e.g.	e.g.	ADV
admet-441	57	30	,	,	PUNCT
admet-441	57	31	bile	bile	NOUN
admet-441	57	32	acids	acid	NOUN
admet-441	57	33	.	.	PUNCT
admet-441	58	1	homeostasis	homeostasis	NOUN
admet-441	58	2	of	of	ADP
admet-441	58	3	bile	bile	NOUN
admet-441	58	4	acid	acid	NOUN
admet-441	58	5	is	be	AUX
admet-441	58	6	maintained	maintain	VERB
admet-441	58	7	through	through	ADP
admet-441	58	8	enterohepatic	enterohepatic	ADJ
admet-441	58	9	circulation	circulation	NOUN
admet-441	58	10	,	,	PUNCT
admet-441	58	11	which	which	PRON
admet-441	58	12	allows	allow	VERB
admet-441	58	13	movement	movement	NOUN
admet-441	58	14	of	of	ADP
admet-441	58	15	bile	bile	NOUN
admet-441	58	16	acid	acid	NOUN
admet-441	58	17	molecules	molecule	NOUN
admet-441	58	18	from	from	ADP
admet-441	58	19	the	the	DET
admet-441	58	20	liver	liver	NOUN
admet-441	58	21	to	to	ADP
admet-441	58	22	the	the	DET
admet-441	58	23	small	small	ADJ
admet-441	58	24	intestine	intestine	NOUN
admet-441	58	25	and	and	CCONJ
admet-441	58	26	back	back	ADV
admet-441	58	27	to	to	ADP
admet-441	58	28	the	the	DET
admet-441	58	29	liver	liver	NOUN
admet-441	58	30	.	.	PUNCT
admet-441	59	1	bile	bile	NOUN
admet-441	59	2	acid	acid	NOUN
admet-441	59	3	transporter	transporter	NOUN
admet-441	59	4	,	,	PUNCT
admet-441	59	5	also	also	ADV
admet-441	59	6	known	know	VERB
admet-441	59	7	as	as	ADP
admet-441	59	8	apical	apical	ADJ
admet-441	59	9	sodium	sodium	NOUN
admet-441	59	10	-	-	PUNCT
admet-441	59	11	dependent	dependent	ADJ
admet-441	59	12	bile	bile	NOUN
admet-441	59	13	acid	acid	NOUN
admet-441	59	14	transporter	transporter	NOUN
admet-441	59	15	,	,	PUNCT
admet-441	59	16	is	be	AUX
admet-441	59	17	considered	consider	VERB
admet-441	59	18	a	a	DET
admet-441	59	19	major	major	ADJ
admet-441	59	20	determinant	determinant	NOUN
admet-441	59	21	of	of	ADP
admet-441	59	22	bile	bile	NOUN
admet-441	59	23	acid	acid	NOUN
admet-441	59	24	homeostasis	homeostasis	NOUN
admet-441	59	25	in	in	ADP
admet-441	59	26	the	the	DET
admet-441	59	27	body	body	NOUN
admet-441	59	28	,	,	PUNCT
admet-441	59	29	and	and	CCONJ
admet-441	59	30	is	be	AUX
admet-441	59	31	an	an	DET
admet-441	59	32	essential	essential	ADJ
admet-441	59	33	regulator	regulator	NOUN
admet-441	59	34	of	of	ADP
admet-441	59	35	lipid	lipid	NOUN
admet-441	59	36	and	and	CCONJ
admet-441	59	37	cholesterol	cholesterol	NOUN
admet-441	59	38	homeostasis	homeostasis	NOUN
admet-441	59	39	[	[	X
admet-441	59	40	39	39	NUM
admet-441	59	41	-	-	SYM
admet-441	59	42	41	41	NUM
admet-441	59	43	]	]	PUNCT
admet-441	59	44	.	.	PUNCT
admet-441	60	1	impaired	impair	VERB
admet-441	60	2	bile	bile	NOUN
admet-441	60	3	acid	acid	NOUN
admet-441	60	4	export	export	NOUN
admet-441	60	5	may	may	AUX
admet-441	60	6	lead	lead	VERB
admet-441	60	7	to	to	ADP
admet-441	60	8	increased	increase	VERB
admet-441	60	9	concentrations	concentration	NOUN
admet-441	60	10	of	of	ADP
admet-441	60	11	liver	liver	NOUN
admet-441	60	12	bile	bile	NOUN
admet-441	60	13	acids	acid	NOUN
admet-441	60	14	,	,	PUNCT
admet-441	60	15	causing	cause	VERB
admet-441	60	16	hepatocellular	hepatocellular	ADJ
admet-441	60	17	apoptosis	apoptosis	NOUN
admet-441	60	18	and/or	and/or	CCONJ
admet-441	60	19	necrosis	necrosis	NOUN
admet-441	60	20	.	.	PUNCT
admet-441	61	1	thus	thus	ADV
admet-441	61	2	,	,	PUNCT
admet-441	61	3	drugs	drug	NOUN
admet-441	61	4	with	with	ADP
admet-441	61	5	the	the	DET
admet-441	61	6	potential	potential	NOUN
admet-441	61	7	to	to	PART
admet-441	61	8	inhibit	inhibit	VERB
admet-441	61	9	these	these	DET
admet-441	61	10	pankajini	pankajini	PROPN
admet-441	61	11	mallick	mallick	PROPN
admet-441	61	12	admet	admet	PROPN
admet-441	61	13	&	&	CCONJ
admet-441	61	14	dmpk	dmpk	PROPN
admet-441	61	15	5(4	5(4	NOUN
admet-441	61	16	)	)	PUNCT
admet-441	61	17	(	(	PUNCT
admet-441	61	18	2017	2017	NUM
admet-441	61	19	)	)	PUNCT
admet-441	61	20	201	201	NUM
admet-441	61	21	-	-	SYM
admet-441	61	22	211	211	NUM
admet-441	61	23	204	204	NUM
admet-441	61	24	transporters	transporter	NOUN
admet-441	61	25	can	can	AUX
admet-441	61	26	disturb	disturb	VERB
admet-441	61	27	the	the	DET
admet-441	61	28	disposition	disposition	NOUN
admet-441	61	29	of	of	ADP
admet-441	61	30	both	both	DET
admet-441	61	31	co	co	ADJ
admet-441	61	32	-	-	ADJ
admet-441	61	33	administered	administered	ADJ
admet-441	61	34	drugs	drug	NOUN
admet-441	61	35	and	and	CCONJ
admet-441	61	36	bile	bile	NOUN
admet-441	61	37	acid	acid	NOUN
admet-441	61	38	,	,	PUNCT
admet-441	61	39	contributing	contribute	VERB
admet-441	61	40	to	to	ADP
admet-441	61	41	the	the	DET
admet-441	61	42	development	development	NOUN
admet-441	61	43	of	of	ADP
admet-441	61	44	cholestatic	cholestatic	ADJ
admet-441	61	45	drug	drug	NOUN
admet-441	61	46	-	-	PUNCT
admet-441	61	47	induced	induce	VERB
admet-441	61	48	liver	liver	NOUN
admet-441	61	49	injury	injury	NOUN
admet-441	61	50	(	(	PUNCT
admet-441	61	51	dili	dili	NOUN
admet-441	61	52	)	)	PUNCT
admet-441	62	1	[	[	X
admet-441	62	2	42	42	NUM
admet-441	62	3	,	,	PUNCT
admet-441	62	4	43	43	NUM
admet-441	62	5	]	]	PUNCT
admet-441	62	6	.	.	PUNCT
admet-441	63	1	in	in	ADP
admet-441	63	2	vitro	vitro	X
admet-441	63	3	studies	study	NOUN
admet-441	63	4	with	with	ADP
admet-441	63	5	isolated	isolated	ADJ
admet-441	63	6	membrane	membrane	NOUN
admet-441	63	7	vesicles	vesicle	NOUN
admet-441	63	8	have	have	AUX
admet-441	63	9	demonstrated	demonstrate	VERB
admet-441	63	10	an	an	DET
admet-441	63	11	association	association	NOUN
admet-441	63	12	between	between	ADP
admet-441	63	13	dili	dili	PROPN
admet-441	63	14	and	and	CCONJ
admet-441	63	15	the	the	DET
admet-441	63	16	inhibitory	inhibitory	ADJ
admet-441	63	17	effects	effect	NOUN
admet-441	63	18	of	of	ADP
admet-441	63	19	drugs	drug	NOUN
admet-441	63	20	on	on	ADP
admet-441	63	21	bile	bile	NOUN
admet-441	63	22	acid	acid	NOUN
admet-441	63	23	efflux	efflux	NOUN
admet-441	63	24	transporters	transporter	NOUN
admet-441	63	25	[	[	X
admet-441	63	26	43	43	NUM
admet-441	63	27	-	-	SYM
admet-441	63	28	45	45	NUM
admet-441	63	29	]	]	PUNCT
admet-441	63	30	.	.	PUNCT
admet-441	64	1	in	in	ADP
admet-441	64	2	vitro	vitro	X
admet-441	64	3	findings	finding	NOUN
admet-441	64	4	may	may	AUX
admet-441	64	5	not	not	PART
admet-441	64	6	translate	translate	VERB
admet-441	64	7	directly	directly	ADV
admet-441	64	8	to	to	ADP
admet-441	64	9	in	in	ADP
admet-441	64	10	vivo	vivo	ADJ
admet-441	64	11	hepatotoxicity	hepatotoxicity	NOUN
admet-441	64	12	risk	risk	NOUN
admet-441	64	13	for	for	ADP
admet-441	64	14	various	various	ADJ
admet-441	64	15	reasons	reason	NOUN
admet-441	64	16	,	,	PUNCT
admet-441	64	17	including	include	VERB
admet-441	64	18	complexity	complexity	NOUN
admet-441	64	19	of	of	ADP
admet-441	64	20	bile	bile	NOUN
admet-441	64	21	acid	acid	NOUN
admet-441	64	22	homeostasis	homeostasis	NOUN
admet-441	64	23	,	,	PUNCT
admet-441	64	24	feedback	feedback	NOUN
admet-441	64	25	regulation	regulation	NOUN
admet-441	64	26	of	of	ADP
admet-441	64	27	bile	bile	NOUN
admet-441	64	28	acid	acid	NOUN
admet-441	64	29	synthesis	synthesis	NOUN
admet-441	64	30	and	and	CCONJ
admet-441	64	31	transport	transport	NOUN
admet-441	64	32	,	,	PUNCT
admet-441	64	33	and	and	CCONJ
admet-441	64	34	dynamic	dynamic	ADJ
admet-441	64	35	drug	drug	NOUN
admet-441	64	36	/	/	SYM
admet-441	64	37	metabolite	metabolite	NOUN
admet-441	64	38	concentrations	concentration	NOUN
admet-441	64	39	in	in	ADP
admet-441	64	40	the	the	DET
admet-441	64	41	system	system	NOUN
admet-441	64	42	[	[	X
admet-441	64	43	46	46	NUM
admet-441	64	44	,	,	PUNCT
admet-441	64	45	47	47	NUM
admet-441	64	46	]	]	PUNCT
admet-441	64	47	.	.	PUNCT
admet-441	65	1	in	in	ADP
admet-441	65	2	vivo	vivo	ADJ
admet-441	65	3	studies	study	NOUN
admet-441	65	4	report	report	VERB
admet-441	65	5	that	that	SCONJ
admet-441	65	6	preclinical	preclinical	ADJ
admet-441	65	7	animals	animal	NOUN
admet-441	65	8	are	be	AUX
admet-441	65	9	less	less	ADV
admet-441	65	10	sensitive	sensitive	ADJ
admet-441	65	11	to	to	ADP
admet-441	65	12	dili	dili	PROPN
admet-441	65	13	caused	cause	VERB
admet-441	65	14	by	by	ADP
admet-441	65	15	bile	bile	NOUN
admet-441	65	16	acid	acid	NOUN
admet-441	65	17	transporter	transporter	NOUN
admet-441	65	18	inhibition	inhibition	NOUN
admet-441	65	19	,	,	PUNCT
admet-441	65	20	as	as	SCONJ
admet-441	65	21	compared	compare	VERB
admet-441	65	22	to	to	ADP
admet-441	65	23	humans	human	NOUN
admet-441	65	24	[	[	X
admet-441	65	25	48	48	NUM
admet-441	65	26	,	,	PUNCT
admet-441	65	27	49	49	NUM
admet-441	65	28	]	]	PUNCT
admet-441	65	29	.	.	PUNCT
admet-441	66	1	therefore	therefore	ADV
admet-441	66	2	,	,	PUNCT
admet-441	66	3	mechanistic	mechanistic	ADJ
admet-441	66	4	models	model	NOUN
admet-441	66	5	that	that	PRON
admet-441	66	6	integrate	integrate	VERB
admet-441	66	7	physiological	physiological	ADJ
admet-441	66	8	information	information	NOUN
admet-441	66	9	and	and	CCONJ
admet-441	66	10	in	in	ADP
admet-441	66	11	vitro	vitro	X
admet-441	66	12	experimental	experimental	ADJ
admet-441	66	13	data	datum	NOUN
admet-441	66	14	to	to	PART
admet-441	66	15	evaluate	evaluate	VERB
admet-441	66	16	dili	dili	NOUN
admet-441	66	17	mechanisms	mechanism	NOUN
admet-441	66	18	may	may	AUX
admet-441	66	19	be	be	AUX
admet-441	66	20	useful	useful	ADJ
admet-441	66	21	to	to	PART
admet-441	66	22	prospectively	prospectively	ADV
admet-441	66	23	predict	predict	VERB
admet-441	66	24	hepatotoxic	hepatotoxic	ADJ
admet-441	66	25	potential	potential	NOUN
admet-441	66	26	of	of	ADP
admet-441	66	27	new	new	ADJ
admet-441	66	28	drug	drug	NOUN
admet-441	66	29	candidates	candidate	NOUN
admet-441	66	30	[	[	X
admet-441	66	31	50	50	NUM
admet-441	66	32	]	]	PUNCT
admet-441	66	33	.	.	PUNCT
admet-441	67	1	the	the	DET
admet-441	67	2	development	development	NOUN
admet-441	67	3	of	of	ADP
admet-441	67	4	a	a	DET
admet-441	67	5	mechanistic	mechanistic	ADJ
admet-441	67	6	model	model	NOUN
admet-441	67	7	to	to	PART
admet-441	67	8	predict	predict	VERB
admet-441	67	9	hepatic	hepatic	ADJ
admet-441	67	10	bile	bile	NOUN
admet-441	67	11	acid	acid	NOUN
admet-441	67	12	transport	transport	NOUN
admet-441	67	13	mediated	mediate	VERB
admet-441	67	14	dili	dili	NOUN
admet-441	67	15	of	of	ADP
admet-441	67	16	troglitazone	troglitazone	PROPN
admet-441	67	17	(	(	PUNCT
admet-441	67	18	tgz	tgz	PROPN
admet-441	67	19	)	)	PUNCT
admet-441	68	1	[	[	X
admet-441	68	2	51	51	NUM
admet-441	68	3	]	]	PUNCT
admet-441	68	4	demonstrated	demonstrate	VERB
admet-441	68	5	the	the	DET
admet-441	68	6	significant	significant	ADJ
admet-441	68	7	contribution	contribution	NOUN
admet-441	68	8	of	of	ADP
admet-441	68	9	pbpk	pbpk	NOUN
admet-441	68	10	modeling	modeling	NOUN
admet-441	68	11	to	to	ADP
admet-441	68	12	the	the	DET
admet-441	68	13	prediction	prediction	NOUN
admet-441	68	14	of	of	ADP
admet-441	68	15	hepatotoxicity	hepatotoxicity	NOUN
admet-441	68	16	due	due	ADP
admet-441	68	17	to	to	ADP
admet-441	68	18	the	the	DET
admet-441	68	19	inhibition	inhibition	NOUN
admet-441	68	20	of	of	ADP
admet-441	68	21	drug	drug	NOUN
admet-441	68	22	transporters	transporter	NOUN
admet-441	68	23	,	,	PUNCT
admet-441	68	24	and	and	CCONJ
admet-441	68	25	the	the	DET
admet-441	68	26	potential	potential	NOUN
admet-441	68	27	of	of	ADP
admet-441	68	28	a	a	DET
admet-441	68	29	transporter	transporter	NOUN
admet-441	68	30	-	-	PUNCT
admet-441	68	31	mediated	mediate	VERB
admet-441	68	32	pbpk	pbpk	ADJ
admet-441	68	33	model	model	NOUN
admet-441	68	34	to	to	PART
admet-441	68	35	aid	aid	VERB
admet-441	68	36	drug	drug	NOUN
admet-441	68	37	development	development	NOUN
admet-441	68	38	.	.	PUNCT
admet-441	69	1	the	the	DET
admet-441	69	2	mechanistic	mechanistic	ADJ
admet-441	69	3	pbpk	pbpk	PROPN
admet-441	69	4	model	model	NOUN
admet-441	69	5	used	use	VERB
admet-441	69	6	to	to	PART
admet-441	69	7	study	study	VERB
admet-441	69	8	the	the	DET
admet-441	69	9	involvement	involvement	NOUN
admet-441	69	10	of	of	ADP
admet-441	69	11	bile	bile	NOUN
admet-441	69	12	acid	acid	NOUN
admet-441	69	13	homeostasis	homeostasis	NOUN
admet-441	69	14	in	in	ADP
admet-441	69	15	tgz	tgz	PROPN
admet-441	69	16	hepatoxicity	hepatoxicity	NOUN
admet-441	69	17	incorporated	incorporate	VERB
admet-441	69	18	drug	drug	NOUN
admet-441	69	19	/	/	SYM
admet-441	69	20	metabolite	metabolite	NOUN
admet-441	69	21	disposition	disposition	NOUN
admet-441	69	22	,	,	PUNCT
admet-441	69	23	bile	bile	NOUN
admet-441	69	24	acid	acid	NOUN
admet-441	69	25	physiology	physiology	NOUN
admet-441	69	26	/	/	SYM
admet-441	69	27	pathophysiology	pathophysiology	NOUN
admet-441	69	28	,	,	PUNCT
admet-441	69	29	and	and	CCONJ
admet-441	69	30	hepatocyte	hepatocyte	NOUN
admet-441	69	31	life	life	NOUN
admet-441	69	32	cycle	cycle	NOUN
admet-441	69	33	.	.	PUNCT
admet-441	70	1	large	large	ADJ
admet-441	70	2	population	population	NOUN
admet-441	70	3	variability	variability	NOUN
admet-441	70	4	in	in	ADP
admet-441	70	5	bile	bile	NOUN
admet-441	70	6	acid	acid	NOUN
admet-441	70	7	exposure	exposure	NOUN
admet-441	70	8	makes	make	VERB
admet-441	70	9	prediction	prediction	NOUN
admet-441	70	10	of	of	ADP
admet-441	70	11	bile	bile	NOUN
admet-441	70	12	acid	acid	NOUN
admet-441	70	13	-	-	PUNCT
admet-441	70	14	mediated	mediate	VERB
admet-441	70	15	hepatotoxicity	hepatotoxicity	NOUN
admet-441	70	16	challenging	challenging	ADJ
admet-441	70	17	;	;	PUNCT
admet-441	70	18	hence	hence	ADV
admet-441	70	19	,	,	PUNCT
admet-441	70	20	the	the	DET
admet-441	70	21	model	model	NOUN
admet-441	70	22	included	include	VERB
admet-441	70	23	population	population	NOUN
admet-441	70	24	-	-	PUNCT
admet-441	70	25	based	base	VERB
admet-441	70	26	analysis	analysis	NOUN
admet-441	70	27	to	to	PART
admet-441	70	28	overcome	overcome	VERB
admet-441	70	29	population	population	NOUN
admet-441	70	30	variability	variability	NOUN
admet-441	70	31	and	and	CCONJ
admet-441	70	32	low	low	ADJ
admet-441	70	33	incidence	incidence	NOUN
admet-441	70	34	of	of	ADP
admet-441	70	35	hepatotoxicity	hepatotoxicity	NOUN
admet-441	70	36	.	.	PUNCT
admet-441	71	1	in	in	ADP
admet-441	71	2	a	a	DET
admet-441	71	3	rat	rat	NOUN
admet-441	71	4	pbpk	pbpk	NOUN
admet-441	71	5	model	model	NOUN
admet-441	71	6	,	,	PUNCT
admet-441	71	7	tgz	tgz	PROPN
admet-441	71	8	was	be	AUX
admet-441	71	9	not	not	PART
admet-441	71	10	hepatotoxic	hepatotoxic	ADJ
admet-441	71	11	;	;	PUNCT
admet-441	71	12	however	however	ADV
admet-441	71	13	,	,	PUNCT
admet-441	71	14	in	in	ADP
admet-441	71	15	a	a	DET
admet-441	71	16	stimulated	stimulated	ADJ
admet-441	71	17	human	human	ADJ
admet-441	71	18	pbpk	pbpk	NOUN
admet-441	71	19	model	model	NOUN
admet-441	71	20	,	,	PUNCT
admet-441	71	21	tgz	tgz	PROPN
admet-441	71	22	resulted	result	VERB
admet-441	71	23	in	in	ADP
admet-441	71	24	a	a	DET
admet-441	71	25	delayed	delay	VERB
admet-441	71	26	increase	increase	NOUN
admet-441	71	27	in	in	ADP
admet-441	71	28	serum	serum	NOUN
admet-441	71	29	alanine	alanine	NOUN
admet-441	71	30	aminotransferase	aminotransferase	PROPN
admet-441	71	31	(	(	PUNCT
admet-441	71	32	alt	alt	PROPN
admet-441	71	33	)	)	PUNCT
admet-441	71	34	(	(	PUNCT
admet-441	71	35	marker	marker	NOUN
admet-441	71	36	of	of	ADP
admet-441	71	37	liver	liver	NOUN
admet-441	71	38	injury	injury	NOUN
admet-441	71	39	)	)	PUNCT
admet-441	71	40	.	.	PUNCT
admet-441	72	1	thus	thus	ADV
admet-441	72	2	,	,	PUNCT
admet-441	72	3	the	the	DET
admet-441	72	4	variability	variability	NOUN
admet-441	72	5	added	add	VERB
admet-441	72	6	to	to	ADP
admet-441	72	7	the	the	DET
admet-441	72	8	parameters	parameter	NOUN
admet-441	72	9	describing	describe	VERB
admet-441	72	10	drug	drug	NOUN
admet-441	72	11	disposition	disposition	NOUN
admet-441	72	12	,	,	PUNCT
admet-441	72	13	body	body	NOUN
admet-441	72	14	weight	weight	NOUN
admet-441	72	15	,	,	PUNCT
admet-441	72	16	and	and	CCONJ
admet-441	72	17	sensitivity	sensitivity	NOUN
admet-441	72	18	of	of	ADP
admet-441	72	19	atp	atp	NOUN
admet-441	72	20	synthesis	synthesis	NOUN
admet-441	72	21	to	to	ADP
admet-441	72	22	hepatic	hepatic	ADJ
admet-441	72	23	bile	bile	NOUN
admet-441	72	24	acid	acid	NOUN
admet-441	72	25	accumulation	accumulation	NOUN
admet-441	72	26	,	,	PUNCT
admet-441	72	27	allowed	allow	VERB
admet-441	72	28	prediction	prediction	NOUN
admet-441	72	29	of	of	ADP
admet-441	72	30	the	the	DET
admet-441	72	31	incidence	incidence	NOUN
admet-441	72	32	of	of	ADP
admet-441	72	33	tgz	tgz	NOUN
admet-441	72	34	hepatotoxicity	hepatotoxicity	NOUN
admet-441	72	35	and	and	CCONJ
admet-441	72	36	the	the	DET
admet-441	72	37	species	specie	NOUN
admet-441	72	38	specific	specific	ADJ
admet-441	72	39	bile	bile	NOUN
admet-441	72	40	acid	acid	NOUN
admet-441	72	41	-	-	PUNCT
admet-441	72	42	mediated	mediate	VERB
admet-441	72	43	dili	dili	NOUN
admet-441	72	44	mechanism	mechanism	NOUN
admet-441	72	45	.	.	PUNCT
admet-441	73	1	intestinal	intestinal	ADJ
admet-441	73	2	transporters	transporter	NOUN
admet-441	73	3	linked	link	VERB
admet-441	73	4	to	to	ADP
admet-441	73	5	ivive	ivive	ADJ
admet-441	73	6	-	-	PUNCT
admet-441	73	7	pbpk	pbpk	ADJ
admet-441	73	8	model	model	NOUN
admet-441	73	9	for	for	ADP
admet-441	73	10	oral	oral	ADJ
admet-441	73	11	absorption	absorption	NOUN
admet-441	73	12	the	the	DET
admet-441	73	13	bioavailability	bioavailability	NOUN
admet-441	73	14	of	of	ADP
admet-441	73	15	an	an	DET
admet-441	73	16	orally	orally	ADV
admet-441	73	17	administered	administer	VERB
admet-441	73	18	drug	drug	NOUN
admet-441	73	19	is	be	AUX
admet-441	73	20	primarily	primarily	ADV
admet-441	73	21	dependent	dependent	ADJ
admet-441	73	22	on	on	ADP
admet-441	73	23	the	the	DET
admet-441	73	24	transporters	transporter	NOUN
admet-441	73	25	expressed	express	VERB
admet-441	73	26	on	on	ADP
admet-441	73	27	the	the	DET
admet-441	73	28	apical	apical	ADJ
admet-441	73	29	/	/	SYM
admet-441	73	30	basolateral	basolateral	ADJ
admet-441	73	31	side	side	NOUN
admet-441	73	32	of	of	ADP
admet-441	73	33	enterocytes	enterocyte	NOUN
admet-441	73	34	that	that	PRON
admet-441	73	35	influence	influence	VERB
admet-441	73	36	both	both	CCONJ
admet-441	73	37	the	the	DET
admet-441	73	38	fraction	fraction	NOUN
admet-441	73	39	of	of	ADP
admet-441	73	40	drug	drug	NOUN
admet-441	73	41	absorbed	absorb	VERB
admet-441	73	42	[	[	PUNCT
admet-441	73	43	52	52	NUM
admet-441	73	44	,	,	PUNCT
admet-441	73	45	53	53	NUM
admet-441	73	46	]	]	PUNCT
admet-441	73	47	and	and	CCONJ
admet-441	73	48	the	the	DET
admet-441	73	49	fraction	fraction	NOUN
admet-441	73	50	escaping	escape	VERB
admet-441	73	51	gut	gut	NOUN
admet-441	73	52	metabolism	metabolism	NOUN
admet-441	73	53	.	.	PUNCT
admet-441	74	1	it	it	PRON
admet-441	74	2	is	be	AUX
admet-441	74	3	difficult	difficult	ADJ
admet-441	74	4	to	to	PART
admet-441	74	5	reproduce	reproduce	VERB
admet-441	74	6	the	the	DET
admet-441	74	7	complexity	complexity	NOUN
admet-441	74	8	of	of	ADP
admet-441	74	9	the	the	DET
admet-441	74	10	human	human	ADJ
admet-441	74	11	gut	gut	NOUN
admet-441	74	12	within	within	ADP
admet-441	74	13	a	a	DET
admet-441	74	14	laboratory	laboratory	NOUN
admet-441	74	15	setting	setting	NOUN
admet-441	74	16	;	;	PUNCT
admet-441	74	17	therefore	therefore	ADV
admet-441	74	18	,	,	PUNCT
admet-441	74	19	efforts	effort	NOUN
admet-441	74	20	are	be	AUX
admet-441	74	21	being	be	AUX
admet-441	74	22	made	make	VERB
admet-441	74	23	to	to	PART
admet-441	74	24	incorporate	incorporate	VERB
admet-441	74	25	drug	drug	NOUN
admet-441	74	26	absorption	absorption	NOUN
admet-441	74	27	into	into	ADP
admet-441	74	28	pbpk	pbpk	NOUN
admet-441	74	29	models	model	NOUN
admet-441	74	30	by	by	ADP
admet-441	74	31	taking	take	VERB
admet-441	74	32	into	into	ADP
admet-441	74	33	account	account	NOUN
admet-441	74	34	several	several	ADJ
admet-441	74	35	physiological	physiological	ADJ
admet-441	74	36	elements	element	NOUN
admet-441	74	37	of	of	ADP
admet-441	74	38	the	the	DET
admet-441	74	39	gastro	gastro	ADJ
admet-441	74	40	-	-	PUNCT
admet-441	74	41	intestinal	intestinal	ADJ
admet-441	74	42	tract	tract	NOUN
admet-441	74	43	,	,	PUNCT
admet-441	74	44	e.g.	e.g.	ADV
admet-441	74	45	,	,	PUNCT
admet-441	74	46	ph	ph	ADJ
admet-441	74	47	,	,	PUNCT
admet-441	74	48	active	active	ADJ
admet-441	74	49	transporters	transporter	NOUN
admet-441	74	50	,	,	PUNCT
admet-441	74	51	and	and	CCONJ
admet-441	74	52	metabolizing	metabolize	VERB
admet-441	74	53	enzymes	enzyme	NOUN
admet-441	74	54	[	[	X
admet-441	74	55	54	54	NUM
admet-441	74	56	]	]	PUNCT
admet-441	74	57	.	.	PUNCT
admet-441	75	1	to	to	PART
admet-441	75	2	mechanistically	mechanistically	ADV
admet-441	75	3	develop	develop	VERB
admet-441	75	4	a	a	DET
admet-441	75	5	pbpk	pbpk	ADJ
admet-441	75	6	model	model	NOUN
admet-441	75	7	,	,	PUNCT
admet-441	75	8	the	the	DET
admet-441	75	9	intestine	intestine	NOUN
admet-441	75	10	essentially	essentially	ADV
admet-441	75	11	accounts	account	VERB
admet-441	75	12	for	for	ADP
admet-441	75	13	the	the	DET
admet-441	75	14	region	region	NOUN
admet-441	75	15	-	-	PUNCT
admet-441	75	16	specific	specific	ADJ
admet-441	75	17	anatomical	anatomical	ADJ
admet-441	75	18	and	and	CCONJ
admet-441	75	19	physiological	physiological	ADJ
admet-441	75	20	differences	difference	NOUN
admet-441	75	21	.	.	PUNCT
admet-441	76	1	advanced	advanced	ADJ
admet-441	76	2	models	model	NOUN
admet-441	76	3	such	such	ADJ
admet-441	76	4	as	as	ADP
admet-441	76	5	the	the	DET
admet-441	76	6	advanced	advanced	ADJ
admet-441	76	7	dissolution	dissolution	NOUN
admet-441	76	8	,	,	PUNCT
admet-441	76	9	absorption	absorption	NOUN
admet-441	76	10	,	,	PUNCT
admet-441	76	11	and	and	CCONJ
admet-441	76	12	metabolism	metabolism	NOUN
admet-441	76	13	(	(	PUNCT
admet-441	76	14	adam	adam	PROPN
admet-441	76	15	)	)	PUNCT
admet-441	76	16	model	model	NOUN
admet-441	76	17	and	and	CCONJ
admet-441	76	18	the	the	DET
admet-441	76	19	advanced	advanced	ADJ
admet-441	76	20	compartmental	compartmental	ADJ
admet-441	76	21	absorption	absorption	NOUN
admet-441	76	22	and	and	CCONJ
admet-441	76	23	transit	transit	NOUN
admet-441	76	24	model	model	NOUN
admet-441	76	25	(	(	PUNCT
admet-441	76	26	acat	acat	ADJ
admet-441	76	27	)	)	PUNCT
admet-441	76	28	are	be	AUX
admet-441	76	29	based	base	VERB
admet-441	76	30	on	on	ADP
admet-441	76	31	adaptations	adaptation	NOUN
admet-441	76	32	of	of	ADP
admet-441	76	33	the	the	DET
admet-441	76	34	original	original	ADJ
admet-441	76	35	compartmental	compartmental	ADJ
admet-441	76	36	absorption	absorption	NOUN
admet-441	76	37	and	and	CCONJ
admet-441	76	38	transit	transit	NOUN
admet-441	76	39	(	(	PUNCT
admet-441	76	40	cat	cat	NOUN
admet-441	76	41	)	)	PUNCT
admet-441	76	42	model	model	NOUN
admet-441	76	43	which	which	PRON
admet-441	76	44	accounts	account	VERB
admet-441	76	45	for	for	ADP
admet-441	76	46	small	small	ADJ
admet-441	76	47	intestinal	intestinal	ADJ
admet-441	76	48	transit	transit	NOUN
admet-441	76	49	time	time	NOUN
admet-441	76	50	(	(	PUNCT
admet-441	76	51	si	si	NOUN
admet-441	76	52	)	)	PUNCT
admet-441	76	53	,	,	PUNCT
admet-441	76	54	permeability	permeability	NOUN
admet-441	76	55	,	,	PUNCT
admet-441	76	56	and	and	CCONJ
admet-441	76	57	radii	radii	VERB
admet-441	76	58	.	.	PUNCT
admet-441	77	1	most	most	ADV
admet-441	77	2	importantly	importantly	ADV
admet-441	77	3	,	,	PUNCT
admet-441	77	4	these	these	DET
admet-441	77	5	advanced	advanced	ADJ
admet-441	77	6	models	model	NOUN
admet-441	77	7	incorporate	incorporate	VERB
admet-441	77	8	gastrointestinal	gastrointestinal	ADJ
admet-441	77	9	transporter	transporter	NOUN
admet-441	77	10	–	–	PUNCT
admet-441	77	11	metabolism	metabolism	NOUN
admet-441	77	12	interplay	interplay	NOUN
admet-441	77	13	[	[	X
admet-441	77	14	55	55	NUM
admet-441	77	15	,	,	PUNCT
admet-441	77	16	56	56	NUM
admet-441	77	17	]	]	PUNCT
admet-441	77	18	.	.	PUNCT
admet-441	78	1	a	a	DET
admet-441	78	2	study	study	NOUN
admet-441	78	3	by	by	ADP
admet-441	78	4	bruyere	bruyere	NOUN
admet-441	78	5	and	and	CCONJ
admet-441	78	6	co	co	NOUN
admet-441	78	7	-	-	NOUN
admet-441	78	8	workers	worker	NOUN
admet-441	78	9	has	have	AUX
admet-441	78	10	highlighted	highlight	VERB
admet-441	78	11	the	the	DET
admet-441	78	12	importance	importance	NOUN
admet-441	78	13	of	of	ADP
admet-441	78	14	obtaining	obtain	VERB
admet-441	78	15	regional	regional	ADJ
admet-441	78	16	intestinal	intestinal	ADJ
admet-441	78	17	transporter	transporter	NOUN
admet-441	78	18	expression	expression	NOUN
admet-441	78	19	data	datum	NOUN
admet-441	78	20	for	for	ADP
admet-441	78	21	incorporation	incorporation	NOUN
admet-441	78	22	in	in	ADP
admet-441	78	23	pbpk	pbpk	ADJ
admet-441	78	24	models	model	NOUN
admet-441	78	25	[	[	X
admet-441	78	26	57	57	NUM
admet-441	78	27	]	]	PUNCT
admet-441	78	28	.	.	PUNCT
admet-441	79	1	this	this	DET
admet-441	79	2	study	study	NOUN
admet-441	79	3	estimated	estimate	VERB
admet-441	79	4	the	the	DET
admet-441	79	5	scaling	scale	VERB
admet-441	79	6	factor	factor	NOUN
admet-441	79	7	based	base	VERB
admet-441	79	8	on	on	ADP
admet-441	79	9	protein	protein	NOUN
admet-441	79	10	estimation	estimation	NOUN
admet-441	79	11	of	of	ADP
admet-441	79	12	both	both	DET
admet-441	79	13	drug	drug	NOUN
admet-441	79	14	metabolizing	metabolize	VERB
admet-441	79	15	enzymes	enzyme	NOUN
admet-441	79	16	and	and	CCONJ
admet-441	79	17	transporters	transporter	NOUN
admet-441	79	18	across	across	ADP
admet-441	79	19	the	the	DET
admet-441	79	20	small	small	ADJ
admet-441	79	21	intestine	intestine	NOUN
admet-441	79	22	;	;	PUNCT
admet-441	79	23	these	these	PRON
admet-441	79	24	were	be	AUX
admet-441	79	25	used	use	VERB
admet-441	79	26	for	for	ADP
admet-441	79	27	predicting	predict	VERB
admet-441	79	28	intestinal	intestinal	ADJ
admet-441	79	29	clearance	clearance	NOUN
admet-441	79	30	and	and	CCONJ
admet-441	79	31	for	for	ADP
admet-441	79	32	the	the	DET
admet-441	79	33	development	development	NOUN
admet-441	79	34	of	of	ADP
admet-441	79	35	an	an	DET
admet-441	79	36	ivive	ivive	ADJ
admet-441	79	37	-	-	PUNCT
admet-441	79	38	pbpk	pbpk	ADJ
admet-441	79	39	model	model	NOUN
admet-441	79	40	.	.	PUNCT
admet-441	80	1	the	the	DET
admet-441	80	2	results	result	NOUN
admet-441	80	3	demonstrated	demonstrate	VERB
admet-441	80	4	that	that	SCONJ
admet-441	80	5	accounting	accounting	NOUN
admet-441	80	6	for	for	ADP
admet-441	80	7	the	the	DET
admet-441	80	8	mdr1	mdr1	PROPN
admet-441	80	9	distributions	distribution	NOUN
admet-441	80	10	enhanced	enhance	VERB
admet-441	80	11	pbpk	pbpk	ADJ
admet-441	80	12	predictions	prediction	NOUN
admet-441	80	13	of	of	ADP
admet-441	80	14	bioavailability	bioavailability	NOUN
admet-441	80	15	for	for	ADP
admet-441	80	16	the	the	DET
admet-441	80	17	development	development	NOUN
admet-441	80	18	of	of	ADP
admet-441	80	19	the	the	DET
admet-441	80	20	compound	compound	NOUN
admet-441	80	21	under	under	ADP
admet-441	80	22	study	study	NOUN
admet-441	80	23	.	.	PUNCT
admet-441	81	1	likewise	likewise	ADV
admet-441	81	2	,	,	PUNCT
admet-441	81	3	a	a	DET
admet-441	81	4	study	study	NOUN
admet-441	81	5	by	by	ADP
admet-441	81	6	darwich	darwich	NOUN
admet-441	81	7	and	and	CCONJ
admet-441	81	8	coworkers	coworker	NOUN
admet-441	81	9	[	[	X
admet-441	81	10	56	56	NUM
admet-441	81	11	]	]	PUNCT
admet-441	81	12	,	,	PUNCT
admet-441	81	13	which	which	PRON
admet-441	81	14	incorporated	incorporate	VERB
admet-441	81	15	regional	regional	ADJ
admet-441	81	16	mdr1	mdr1	PROPN
admet-441	81	17	and	and	CCONJ
admet-441	81	18	cyp3a	cyp3a	NOUN
admet-441	81	19	expression	expression	NOUN
admet-441	81	20	into	into	ADP
admet-441	81	21	an	an	DET
admet-441	81	22	adam	adam	PROPN
admet-441	81	23	model	model	NOUN
admet-441	81	24	,	,	PUNCT
admet-441	81	25	demonstrated	demonstrate	VERB
admet-441	81	26	two	two	NUM
admet-441	81	27	points	point	NOUN
admet-441	81	28	:	:	PUNCT
admet-441	81	29	non	non	ADJ
admet-441	81	30	-	-	ADJ
admet-441	81	31	uniform	uniform	ADJ
admet-441	81	32	regional	regional	ADJ
admet-441	81	33	distribution	distribution	NOUN
admet-441	81	34	of	of	ADP
admet-441	81	35	mdr1	mdr1	PROPN
admet-441	81	36	in	in	ADP
admet-441	81	37	the	the	DET
admet-441	81	38	small	small	ADJ
admet-441	81	39	intestine	intestine	NOUN
admet-441	81	40	and	and	CCONJ
admet-441	81	41	colon	colon	NOUN
admet-441	81	42	,	,	PUNCT
admet-441	81	43	and	and	CCONJ
admet-441	81	44	disparity	disparity	NOUN
admet-441	81	45	between	between	ADP
admet-441	81	46	mrna	mrna	PROPN
admet-441	81	47	and	and	CCONJ
admet-441	81	48	protein	protein	NOUN
admet-441	81	49	expression	expression	NOUN
admet-441	81	50	.	.	PUNCT
admet-441	82	1	this	this	DET
admet-441	82	2	highlights	highlight	NOUN
admet-441	82	3	that	that	PRON
admet-441	82	4	protein	protein	NOUN
admet-441	82	5	and	and	CCONJ
admet-441	82	6	mrna	mrna	PROPN
admet-441	82	7	expression	expression	NOUN
admet-441	82	8	together	together	ADV
admet-441	82	9	with	with	ADP
admet-441	82	10	drug	drug	NOUN
admet-441	82	11	parameter	parameter	NOUN
admet-441	82	12	data	datum	NOUN
admet-441	82	13	leads	lead	VERB
admet-441	82	14	to	to	ADP
admet-441	82	15	successful	successful	ADJ
admet-441	82	16	capture	capture	NOUN
admet-441	82	17	of	of	ADP
admet-441	82	18	drug	drug	NOUN
admet-441	82	19	disposition	disposition	NOUN
admet-441	82	20	.	.	PUNCT
admet-441	83	1	the	the	DET
admet-441	83	2	mechanistic	mechanistic	ADJ
admet-441	83	3	pbpk	pbpk	PROPN
admet-441	83	4	admet	admet	PROPN
admet-441	83	5	&	&	CCONJ
admet-441	83	6	dmpk	dmpk	PROPN
admet-441	83	7	5(4	5(4	NOUN
admet-441	83	8	)	)	PUNCT
admet-441	83	9	(	(	PUNCT
admet-441	83	10	2017	2017	NUM
admet-441	83	11	)	)	PUNCT
admet-441	83	12	201	201	NUM
admet-441	83	13	-	-	SYM
admet-441	83	14	211	211	NUM
admet-441	83	15	utilizing	utilize	VERB
admet-441	83	16	in	in	ADP
admet-441	83	17	vitro	vitro	X
admet-441	83	18	transporter	transporter	NOUN
admet-441	83	19	data	datum	NOUN
admet-441	83	20	in	in	ADP
admet-441	83	21	ivive	ivive	ADJ
admet-441	83	22	-	-	PUNCT
admet-441	83	23	pbpk	pbpk	ADJ
admet-441	83	24	doi	doi	NOUN
admet-441	83	25	:	:	PUNCT
admet-441	83	26	10.5599	10.5599	NUM
admet-441	83	27	/	/	SYM
admet-441	83	28	admet.5.4.441	admet.5.4.441	NUM
admet-441	83	29	205	205	NUM
admet-441	83	30	absorption	absorption	NOUN
admet-441	83	31	model	model	NOUN
admet-441	83	32	of	of	ADP
admet-441	83	33	oxybutynin	oxybutynin	PROPN
admet-441	83	34	(	(	PUNCT
admet-441	83	35	oxy	oxy	PROPN
admet-441	83	36	)	)	PUNCT
admet-441	83	37	was	be	AUX
admet-441	83	38	based	base	VERB
admet-441	83	39	on	on	ADP
admet-441	83	40	a	a	DET
admet-441	83	41	cat	cat	NOUN
admet-441	83	42	model	model	NOUN
admet-441	83	43	that	that	PRON
admet-441	83	44	predicts	predict	VERB
admet-441	83	45	the	the	DET
admet-441	83	46	fraction	fraction	NOUN
admet-441	83	47	absorbed	absorb	VERB
admet-441	83	48	based	base	VERB
admet-441	83	49	on	on	ADP
admet-441	83	50	permeability	permeability	NOUN
admet-441	83	51	data	datum	NOUN
admet-441	83	52	in	in	ADP
admet-441	83	53	order	order	NOUN
admet-441	83	54	to	to	PART
admet-441	83	55	predict	predict	VERB
admet-441	83	56	oxy	oxy	PROPN
admet-441	83	57	’s	’s	PART
admet-441	83	58	oral	oral	ADJ
admet-441	83	59	bioavailability	bioavailability	NOUN
admet-441	83	60	,	,	PUNCT
admet-441	83	61	for	for	ADP
admet-441	83	62	two	two	NUM
admet-441	83	63	different	different	ADJ
admet-441	83	64	formulations	formulation	NOUN
admet-441	83	65	:	:	PUNCT
admet-441	83	66	immediate	immediate	ADJ
admet-441	83	67	-	-	PUNCT
admet-441	83	68	release	release	NOUN
admet-441	83	69	(	(	PUNCT
admet-441	83	70	ir	ir	NOUN
admet-441	83	71	)	)	PUNCT
admet-441	83	72	and	and	CCONJ
admet-441	83	73	modified	modify	VERB
admet-441	83	74	-	-	PUNCT
admet-441	83	75	release	release	NOUN
admet-441	83	76	(	(	PUNCT
admet-441	83	77	mr	mr	PROPN
admet-441	83	78	)	)	PUNCT
admet-441	84	1	[	[	X
admet-441	84	2	58	58	NUM
admet-441	84	3	]	]	PUNCT
admet-441	84	4	.	.	PUNCT
admet-441	85	1	as	as	SCONJ
admet-441	85	2	the	the	DET
admet-441	85	3	primary	primary	ADJ
admet-441	85	4	objective	objective	NOUN
admet-441	85	5	is	be	AUX
admet-441	85	6	to	to	PART
admet-441	85	7	predict	predict	VERB
admet-441	85	8	the	the	DET
admet-441	85	9	fraction	fraction	NOUN
admet-441	85	10	absorbed	absorb	VERB
admet-441	85	11	,	,	PUNCT
admet-441	85	12	this	this	DET
admet-441	85	13	multi	multi	ADJ
admet-441	85	14	-	-	ADJ
admet-441	85	15	compartmental	compartmental	ADJ
admet-441	85	16	absorption	absorption	NOUN
admet-441	85	17	model	model	NOUN
admet-441	85	18	was	be	AUX
admet-441	85	19	a	a	DET
admet-441	85	20	simplified	simplified	ADJ
admet-441	85	21	version	version	NOUN
admet-441	85	22	of	of	ADP
admet-441	85	23	a	a	DET
admet-441	85	24	cat	cat	NOUN
admet-441	85	25	model	model	NOUN
admet-441	85	26	used	use	VERB
admet-441	85	27	to	to	PART
admet-441	85	28	divide	divide	VERB
admet-441	85	29	the	the	DET
admet-441	85	30	small	small	ADJ
admet-441	85	31	intestine	intestine	NOUN
admet-441	85	32	into	into	ADP
admet-441	85	33	three	three	NUM
admet-441	85	34	compartments	compartment	NOUN
admet-441	85	35	instead	instead	ADV
admet-441	85	36	of	of	ADP
admet-441	85	37	seven	seven	NUM
admet-441	85	38	,	,	PUNCT
admet-441	85	39	including	include	VERB
admet-441	85	40	the	the	DET
admet-441	85	41	duodenum	duodenum	ADJ
admet-441	85	42	,	,	PUNCT
admet-441	85	43	jejunum	jejunum	ADJ
admet-441	85	44	,	,	PUNCT
admet-441	85	45	and	and	CCONJ
admet-441	85	46	ileum	ileum	NOUN
admet-441	85	47	.	.	PUNCT
admet-441	86	1	the	the	DET
admet-441	86	2	model	model	NOUN
admet-441	86	3	allowed	allow	VERB
admet-441	86	4	the	the	DET
admet-441	86	5	drug	drug	NOUN
admet-441	86	6	amount	amount	NOUN
admet-441	86	7	to	to	PART
admet-441	86	8	be	be	AUX
admet-441	86	9	modelled	model	VERB
admet-441	86	10	,	,	PUNCT
admet-441	86	11	either	either	CCONJ
admet-441	86	12	in	in	ADP
admet-441	86	13	solid	solid	ADJ
admet-441	86	14	or	or	CCONJ
admet-441	86	15	dissolved	dissolve	VERB
admet-441	86	16	state	state	NOUN
admet-441	86	17	,	,	PUNCT
admet-441	86	18	for	for	ADP
admet-441	86	19	each	each	DET
admet-441	86	20	segment	segment	NOUN
admet-441	86	21	.	.	PUNCT
admet-441	87	1	assumptions	assumption	NOUN
admet-441	87	2	made	make	VERB
admet-441	87	3	included	include	VERB
admet-441	87	4	:	:	PUNCT
admet-441	87	5	well	well	ADV
admet-441	87	6	mixed	mixed	ADJ
admet-441	87	7	gi	gi	NOUN
admet-441	87	8	compartments	compartment	NOUN
admet-441	87	9	,	,	PUNCT
admet-441	87	10	no	no	DET
admet-441	87	11	drug	drug	NOUN
admet-441	87	12	degradation	degradation	NOUN
admet-441	87	13	in	in	ADP
admet-441	87	14	the	the	DET
admet-441	87	15	gi	gi	NOUN
admet-441	87	16	tract	tract	NOUN
admet-441	87	17	,	,	PUNCT
admet-441	87	18	only	only	ADV
admet-441	87	19	the	the	DET
admet-441	87	20	dissolved	dissolve	VERB
admet-441	87	21	drug	drug	NOUN
admet-441	87	22	to	to	PART
admet-441	87	23	be	be	AUX
admet-441	87	24	absorbed	absorb	VERB
admet-441	87	25	,	,	PUNCT
admet-441	87	26	and	and	CCONJ
admet-441	87	27	absorption	absorption	NOUN
admet-441	87	28	to	to	PART
admet-441	87	29	be	be	AUX
admet-441	87	30	a	a	DET
admet-441	87	31	non	non	ADJ
admet-441	87	32	-	-	ADJ
admet-441	87	33	saturable	saturable	ADJ
admet-441	87	34	process	process	NOUN
admet-441	87	35	.	.	PUNCT
admet-441	88	1	transfer	transfer	NOUN
admet-441	88	2	of	of	ADP
admet-441	88	3	mass	mass	NOUN
admet-441	88	4	between	between	ADP
admet-441	88	5	adjacent	adjacent	ADJ
admet-441	88	6	segments	segment	NOUN
admet-441	88	7	was	be	AUX
admet-441	88	8	considered	consider	VERB
admet-441	88	9	to	to	PART
admet-441	88	10	follow	follow	VERB
admet-441	88	11	first	first	ADJ
admet-441	88	12	-	-	PUNCT
admet-441	88	13	order	order	NOUN
admet-441	88	14	kinetics	kinetic	NOUN
admet-441	88	15	,	,	PUNCT
admet-441	88	16	controlled	control	VERB
admet-441	88	17	by	by	ADP
admet-441	88	18	a	a	DET
admet-441	88	19	rate	rate	NOUN
admet-441	88	20	constant	constant	ADJ
admet-441	88	21	of	of	ADP
admet-441	88	22	gastric	gastric	ADJ
admet-441	88	23	emptying	emptying	NOUN
admet-441	88	24	.	.	PUNCT
admet-441	89	1	the	the	DET
admet-441	89	2	dissolution	dissolution	ADJ
admet-441	89	3	rate	rate	NOUN
admet-441	89	4	of	of	ADP
admet-441	89	5	oxy	oxy	NOUN
admet-441	89	6	was	be	AUX
admet-441	89	7	modeled	model	VERB
admet-441	89	8	based	base	VERB
admet-441	89	9	on	on	ADP
admet-441	89	10	spherical	spherical	ADJ
admet-441	89	11	particles	particle	NOUN
admet-441	89	12	dissolving	dissolve	VERB
admet-441	89	13	over	over	ADP
admet-441	89	14	time	time	NOUN
admet-441	89	15	[	[	X
admet-441	89	16	55	55	NUM
admet-441	89	17	]	]	PUNCT
admet-441	89	18	.	.	PUNCT
admet-441	90	1	further	far	ADV
admet-441	90	2	,	,	PUNCT
admet-441	90	3	oxy	oxy	PROPN
admet-441	90	4	’s	’s	PART
admet-441	90	5	regional	regional	ADJ
admet-441	90	6	intestinal	intestinal	ADJ
admet-441	90	7	metabolism	metabolism	NOUN
admet-441	90	8	was	be	AUX
admet-441	90	9	modeled	model	VERB
admet-441	90	10	through	through	ADP
admet-441	90	11	an	an	DET
admet-441	90	12	enterocyte	enterocyte	NOUN
admet-441	90	13	compartment	compartment	NOUN
admet-441	90	14	,	,	PUNCT
admet-441	90	15	with	with	ADP
admet-441	90	16	the	the	DET
admet-441	90	17	assumptions	assumption	NOUN
admet-441	90	18	that	that	SCONJ
admet-441	90	19	the	the	DET
admet-441	90	20	metabolism	metabolism	NOUN
admet-441	90	21	in	in	ADP
admet-441	90	22	the	the	DET
admet-441	90	23	liver	liver	NOUN
admet-441	90	24	and	and	CCONJ
admet-441	90	25	intestine	intestine	NOUN
admet-441	90	26	was	be	AUX
admet-441	90	27	equal	equal	ADJ
admet-441	90	28	,	,	PUNCT
admet-441	90	29	and	and	CCONJ
admet-441	90	30	there	there	PRON
admet-441	90	31	was	be	VERB
admet-441	90	32	no	no	DET
admet-441	90	33	binding	bind	VERB
admet-441	90	34	to	to	ADP
admet-441	90	35	enterocytes	enterocyte	NOUN
admet-441	90	36	.	.	PUNCT
admet-441	91	1	the	the	DET
admet-441	91	2	model	model	NOUN
admet-441	91	3	showed	show	VERB
admet-441	91	4	that	that	SCONJ
admet-441	91	5	the	the	DET
admet-441	91	6	fraction	fraction	NOUN
admet-441	91	7	absorbed	absorb	VERB
admet-441	91	8	from	from	ADP
admet-441	91	9	the	the	DET
admet-441	91	10	formulation	formulation	NOUN
admet-441	91	11	was	be	AUX
admet-441	91	12	reduced	reduce	VERB
admet-441	91	13	compared	compare	VERB
admet-441	91	14	to	to	ADP
admet-441	91	15	ir	ir	PROPN
admet-441	91	16	,	,	PUNCT
admet-441	91	17	despite	despite	SCONJ
admet-441	91	18	higher	high	ADJ
admet-441	91	19	intestinal	intestinal	ADJ
admet-441	91	20	availability	availability	NOUN
admet-441	91	21	of	of	ADP
admet-441	91	22	the	the	DET
admet-441	91	23	formulation	formulation	NOUN
admet-441	91	24	.	.	PUNCT
admet-441	92	1	considering	consider	VERB
admet-441	92	2	the	the	DET
admet-441	92	3	assumption	assumption	NOUN
admet-441	92	4	that	that	SCONJ
admet-441	92	5	the	the	DET
admet-441	92	6	fraction	fraction	NOUN
admet-441	92	7	remaining	remain	VERB
admet-441	92	8	in	in	ADP
admet-441	92	9	the	the	DET
admet-441	92	10	liver	liver	NOUN
admet-441	92	11	and	and	CCONJ
admet-441	92	12	intestine	intestine	NOUN
admet-441	92	13	is	be	AUX
admet-441	92	14	the	the	DET
admet-441	92	15	same	same	ADJ
admet-441	92	16	,	,	PUNCT
admet-441	92	17	the	the	DET
admet-441	92	18	model	model	NOUN
admet-441	92	19	prediction	prediction	NOUN
admet-441	92	20	supported	support	VERB
admet-441	92	21	the	the	DET
admet-441	92	22	hypothesis	hypothesis	NOUN
admet-441	92	23	that	that	PRON
admet-441	92	24	higher	high	ADJ
admet-441	92	25	bioavailability	bioavailability	NOUN
admet-441	92	26	with	with	ADP
admet-441	92	27	the	the	DET
admet-441	92	28	oxy	oxy	ADJ
admet-441	92	29	formulation	formulation	NOUN
admet-441	92	30	is	be	AUX
admet-441	92	31	due	due	ADJ
admet-441	92	32	to	to	ADP
admet-441	92	33	increased	increase	VERB
admet-441	92	34	intestinal	intestinal	ADJ
admet-441	92	35	availability	availability	NOUN
admet-441	92	36	.	.	PUNCT
admet-441	93	1	ivive	ivive	ADJ
admet-441	93	2	-	-	PUNCT
admet-441	93	3	pbpk	pbpk	ADJ
admet-441	93	4	model	model	NOUN
admet-441	93	5	for	for	ADP
admet-441	93	6	the	the	DET
admet-441	93	7	central	central	ADJ
admet-441	93	8	nervous	nervous	ADJ
admet-441	93	9	system	system	NOUN
admet-441	93	10	given	give	VERB
admet-441	93	11	the	the	DET
admet-441	93	12	high	high	ADJ
admet-441	93	13	failure	failure	NOUN
admet-441	93	14	rate	rate	NOUN
admet-441	93	15	of	of	ADP
admet-441	93	16	drugs	drug	NOUN
admet-441	93	17	developed	develop	VERB
admet-441	93	18	for	for	ADP
admet-441	93	19	central	central	ADJ
admet-441	93	20	nervous	nervous	ADJ
admet-441	93	21	system	system	NOUN
admet-441	93	22	(	(	PUNCT
admet-441	93	23	cns	cns	NOUN
admet-441	93	24	)	)	PUNCT
admet-441	93	25	indications	indication	NOUN
admet-441	93	26	[	[	X
admet-441	93	27	59	59	NUM
admet-441	93	28	]	]	PUNCT
admet-441	93	29	,	,	PUNCT
admet-441	93	30	early	early	ADJ
admet-441	93	31	and	and	CCONJ
admet-441	93	32	accurate	accurate	ADJ
admet-441	93	33	prediction	prediction	NOUN
admet-441	93	34	of	of	ADP
admet-441	93	35	drug	drug	NOUN
admet-441	93	36	penetration	penetration	NOUN
admet-441	93	37	across	across	ADP
admet-441	93	38	the	the	DET
admet-441	93	39	blood	blood	NOUN
admet-441	93	40	–	–	PUNCT
admet-441	93	41	brain	brain	NOUN
admet-441	93	42	barrier	barrier	NOUN
admet-441	93	43	(	(	PUNCT
admet-441	93	44	bbb	bbb	NOUN
admet-441	93	45	)	)	PUNCT
admet-441	93	46	is	be	AUX
admet-441	93	47	vital	vital	ADJ
admet-441	93	48	during	during	ADP
admet-441	93	49	drug	drug	NOUN
admet-441	93	50	development	development	NOUN
admet-441	93	51	.	.	PUNCT
admet-441	94	1	further	far	ADV
admet-441	94	2	,	,	PUNCT
admet-441	94	3	the	the	DET
admet-441	94	4	prediction	prediction	NOUN
admet-441	94	5	of	of	ADP
admet-441	94	6	brain	brain	NOUN
admet-441	94	7	penetration	penetration	NOUN
admet-441	94	8	for	for	ADP
admet-441	94	9	non	non	ADJ
admet-441	94	10	-	-	ADJ
admet-441	94	11	cns	cns	ADJ
admet-441	94	12	drugs	drug	NOUN
admet-441	94	13	is	be	AUX
admet-441	94	14	important	important	ADJ
admet-441	94	15	during	during	ADP
admet-441	94	16	drug	drug	NOUN
admet-441	94	17	development	development	NOUN
admet-441	94	18	,	,	PUNCT
admet-441	94	19	in	in	ADP
admet-441	94	20	order	order	NOUN
admet-441	94	21	to	to	PART
admet-441	94	22	avoid	avoid	VERB
admet-441	94	23	unwanted	unwanted	ADJ
admet-441	94	24	neurotoxicity	neurotoxicity	NOUN
admet-441	94	25	.	.	PUNCT
admet-441	95	1	human	human	ADJ
admet-441	95	2	pharmacokinetic	pharmacokinetic	ADJ
admet-441	95	3	data	datum	NOUN
admet-441	95	4	from	from	ADP
admet-441	95	5	the	the	DET
admet-441	95	6	brain	brain	NOUN
admet-441	95	7	is	be	AUX
admet-441	95	8	highly	highly	ADV
admet-441	95	9	restricted	restrict	VERB
admet-441	95	10	;	;	PUNCT
admet-441	95	11	thus	thus	ADV
admet-441	95	12	,	,	PUNCT
admet-441	95	13	pbpk	pbpk	NOUN
admet-441	95	14	modeling	modeling	NOUN
admet-441	95	15	is	be	AUX
admet-441	95	16	of	of	ADP
admet-441	95	17	significant	significant	ADJ
admet-441	95	18	value	value	NOUN
admet-441	95	19	as	as	SCONJ
admet-441	95	20	it	it	PRON
admet-441	95	21	can	can	AUX
admet-441	95	22	be	be	AUX
admet-441	95	23	used	use	VERB
admet-441	95	24	to	to	PART
admet-441	95	25	predict	predict	VERB
admet-441	95	26	the	the	DET
admet-441	95	27	target	target	NOUN
admet-441	95	28	site	site	NOUN
admet-441	95	29	concentrations	concentration	NOUN
admet-441	95	30	in	in	ADP
admet-441	95	31	inter	inter	NOUN
admet-441	95	32	-	-	NOUN
admet-441	95	33	species	specie	NOUN
admet-441	95	34	and	and	CCONJ
admet-441	95	35	inter	inter	ADJ
admet-441	95	36	-	-	ADJ
admet-441	95	37	disease	disease	ADJ
admet-441	95	38	situations	situation	NOUN
admet-441	95	39	[	[	X
admet-441	95	40	60	60	NUM
admet-441	95	41	-	-	SYM
admet-441	95	42	62	62	NUM
admet-441	95	43	]	]	PUNCT
admet-441	95	44	.	.	PUNCT
admet-441	96	1	however	however	ADV
admet-441	96	2	,	,	PUNCT
admet-441	96	3	until	until	ADP
admet-441	96	4	recently	recently	ADV
admet-441	96	5	,	,	PUNCT
admet-441	96	6	there	there	PRON
admet-441	96	7	has	have	AUX
admet-441	96	8	been	be	AUX
admet-441	96	9	relatively	relatively	ADV
admet-441	96	10	few	few	ADJ
admet-441	96	11	published	publish	VERB
admet-441	96	12	ivive	ivive	ADJ
admet-441	96	13	-	-	PUNCT
admet-441	96	14	pbpk	pbpk	ADJ
admet-441	96	15	models	model	NOUN
admet-441	96	16	to	to	PART
admet-441	96	17	predict	predict	VERB
admet-441	96	18	bbb	bbb	PROPN
admet-441	96	19	permeability	permeability	NOUN
admet-441	96	20	,	,	PUNCT
admet-441	96	21	mostly	mostly	ADV
admet-441	96	22	due	due	ADJ
admet-441	96	23	to	to	ADP
admet-441	96	24	limitations	limitation	NOUN
admet-441	96	25	in	in	ADP
admet-441	96	26	the	the	DET
admet-441	96	27	current	current	ADJ
admet-441	96	28	in	in	ADP
admet-441	96	29	vitro	vitro	X
admet-441	96	30	systems	system	NOUN
admet-441	96	31	used	use	VERB
admet-441	96	32	to	to	PART
admet-441	96	33	represent	represent	VERB
admet-441	96	34	the	the	DET
admet-441	96	35	complex	complex	ADJ
admet-441	96	36	and	and	CCONJ
admet-441	96	37	transporter	transporter	NOUN
admet-441	96	38	-	-	PUNCT
admet-441	96	39	rich	rich	ADJ
admet-441	96	40	structure	structure	NOUN
admet-441	96	41	of	of	ADP
admet-441	96	42	the	the	DET
admet-441	96	43	in	in	ADP
admet-441	96	44	vivo	vivo	ADJ
admet-441	96	45	bbb	bbb	NOUN
admet-441	96	46	,	,	PUNCT
admet-441	96	47	and	and	CCONJ
admet-441	96	48	due	due	ADP
admet-441	96	49	to	to	ADP
admet-441	96	50	difficulty	difficulty	NOUN
admet-441	96	51	in	in	ADP
admet-441	96	52	obtaining	obtain	VERB
admet-441	96	53	the	the	DET
admet-441	96	54	appropriate	appropriate	ADJ
admet-441	96	55	in	in	ADP
admet-441	96	56	vitro	vitro	X
admet-441	96	57	–	–	PUNCT
admet-441	96	58	in	in	ADP
admet-441	96	59	vivo	vivo	ADJ
admet-441	96	60	scaling	scale	VERB
admet-441	96	61	factors	factor	NOUN
admet-441	96	62	[	[	X
admet-441	96	63	63	63	NUM
admet-441	96	64	]	]	PUNCT
admet-441	96	65	.	.	PUNCT
admet-441	97	1	a	a	DET
admet-441	97	2	generic	generic	ADJ
admet-441	97	3	multicompartmental	multicompartmental	NOUN
admet-441	97	4	cns	cns	NOUN
admet-441	97	5	distribution	distribution	NOUN
admet-441	97	6	model	model	NOUN
admet-441	97	7	structure	structure	NOUN
admet-441	97	8	proposed	propose	VERB
admet-441	97	9	by	by	ADP
admet-441	97	10	yamamoto	yamamoto	PROPN
admet-441	97	11	et	et	PROPN
admet-441	97	12	al	al	PROPN
admet-441	98	1	[	[	X
admet-441	98	2	64	64	NUM
admet-441	98	3	]	]	PUNCT
admet-441	98	4	,	,	PUNCT
admet-441	98	5	based	base	VERB
admet-441	98	6	on	on	ADP
admet-441	98	7	the	the	DET
admet-441	98	8	compounds	compound	NOUN
admet-441	98	9	acetaminophen	acetaminophen	NOUN
admet-441	98	10	,	,	PUNCT
admet-441	98	11	atenolol	atenolol	PROPN
admet-441	98	12	,	,	PUNCT
admet-441	98	13	methotrexate	methotrexate	NOUN
admet-441	98	14	,	,	PUNCT
admet-441	98	15	morphine	morphine	NOUN
admet-441	98	16	,	,	PUNCT
admet-441	98	17	paliperidone	paliperidone	NOUN
admet-441	98	18	,	,	PUNCT
admet-441	98	19	phenytoin	phenytoin	NOUN
admet-441	98	20	,	,	PUNCT
admet-441	98	21	quinidine	quinidine	ADJ
admet-441	98	22	,	,	PUNCT
admet-441	98	23	remoxipride	remoxipride	ADJ
admet-441	98	24	,	,	PUNCT
admet-441	98	25	and	and	CCONJ
admet-441	98	26	risperidone	risperidone	NOUN
admet-441	98	27	,	,	PUNCT
admet-441	98	28	successfully	successfully	ADV
admet-441	98	29	described	describe	VERB
admet-441	98	30	the	the	DET
admet-441	98	31	pharmacokinetics	pharmacokinetic	NOUN
admet-441	98	32	in	in	ADP
admet-441	98	33	plasma	plasma	NOUN
admet-441	98	34	and	and	CCONJ
admet-441	98	35	different	different	ADJ
admet-441	98	36	cns	cns	NOUN
admet-441	98	37	compartments	compartment	NOUN
admet-441	98	38	[	[	X
admet-441	98	39	64	64	NUM
admet-441	98	40	]	]	PUNCT
admet-441	98	41	.	.	PUNCT
admet-441	99	1	prediction	prediction	NOUN
admet-441	99	2	of	of	ADP
admet-441	99	3	this	this	DET
admet-441	99	4	multi	multi	ADJ
admet-441	99	5	-	-	ADJ
admet-441	99	6	compartmental	compartmental	ADJ
admet-441	99	7	brain	brain	NOUN
admet-441	99	8	pk	pk	NOUN
admet-441	99	9	model	model	NOUN
admet-441	99	10	matched	match	VERB
admet-441	99	11	well	well	ADV
admet-441	99	12	with	with	ADP
admet-441	99	13	the	the	DET
admet-441	99	14	observed	observe	VERB
admet-441	99	15	concentration	concentration	NOUN
admet-441	99	16	-	-	PUNCT
admet-441	99	17	time	time	NOUN
admet-441	99	18	profiles	profile	NOUN
admet-441	99	19	,	,	PUNCT
admet-441	99	20	adequately	adequately	ADV
admet-441	99	21	describing	describe	VERB
admet-441	99	22	the	the	DET
admet-441	99	23	data	datum	NOUN
admet-441	99	24	for	for	ADP
admet-441	99	25	all	all	DET
admet-441	99	26	compounds	compound	NOUN
admet-441	99	27	studied	study	VERB
admet-441	99	28	.	.	PUNCT
admet-441	100	1	the	the	DET
admet-441	100	2	model	model	NOUN
admet-441	100	3	structure	structure	NOUN
admet-441	100	4	comprised	comprise	VERB
admet-441	100	5	physiologically	physiologically	ADV
admet-441	100	6	relevant	relevant	ADJ
admet-441	100	7	brain	brain	NOUN
admet-441	100	8	compartments	compartment	NOUN
admet-441	100	9	including	include	VERB
admet-441	100	10	brain	brain	NOUN
admet-441	100	11	extracellular	extracellular	ADJ
admet-441	100	12	fraction	fraction	NOUN
admet-441	100	13	(	(	PUNCT
admet-441	100	14	brainecf	brainecf	NOUN
admet-441	100	15	)	)	PUNCT
admet-441	100	16	,	,	PUNCT
admet-441	100	17	brain	brain	NOUN
admet-441	100	18	intracellular	intracellular	ADJ
admet-441	100	19	fluid	fluid	ADJ
admet-441	100	20	compartment	compartment	NOUN
admet-441	100	21	(	(	PUNCT
admet-441	100	22	brainicf	brainicf	NOUN
admet-441	100	23	)	)	PUNCT
admet-441	100	24	,	,	PUNCT
admet-441	100	25	compartment	compartment	NOUN
admet-441	100	26	of	of	ADP
admet-441	100	27	cerebrospinal	cerebrospinal	ADJ
admet-441	100	28	fluid	fluid	NOUN
admet-441	100	29	(	(	PUNCT
admet-441	100	30	csf	csf	NOUN
admet-441	100	31	)	)	PUNCT
admet-441	100	32	in	in	ADP
admet-441	100	33	lateral	lateral	ADJ
admet-441	100	34	ventricle	ventricle	NOUN
admet-441	100	35	(	(	PUNCT
admet-441	100	36	csflv	csflv	NOUN
admet-441	100	37	)	)	PUNCT
admet-441	100	38	,	,	PUNCT
admet-441	100	39	compartment	compartment	NOUN
admet-441	100	40	of	of	ADP
admet-441	100	41	csf	csf	NOUN
admet-441	100	42	in	in	ADP
admet-441	100	43	third	third	ADJ
admet-441	100	44	and	and	CCONJ
admet-441	100	45	fourth	fourth	ADJ
admet-441	100	46	ventricle	ventricle	NOUN
admet-441	100	47	(	(	PUNCT
admet-441	100	48	csftfv	csftfv	NOUN
admet-441	100	49	)	)	PUNCT
admet-441	100	50	,	,	PUNCT
admet-441	100	51	compartment	compartment	NOUN
admet-441	100	52	of	of	ADP
admet-441	100	53	csf	csf	NOUN
admet-441	100	54	in	in	ADP
admet-441	100	55	cisterna	cisterna	PROPN
admet-441	100	56	magna	magna	PROPN
admet-441	100	57	(	(	PUNCT
admet-441	100	58	csfcm	csfcm	PROPN
admet-441	100	59	)	)	PUNCT
admet-441	100	60	,	,	PUNCT
admet-441	100	61	and	and	CCONJ
admet-441	100	62	csf	csf	VERB
admet-441	100	63	subarachnoid	subarachnoid	NOUN
admet-441	100	64	space	space	NOUN
admet-441	100	65	(	(	PUNCT
admet-441	100	66	csfsas	csfsa	NOUN
admet-441	100	67	)	)	PUNCT
admet-441	100	68	.	.	PUNCT
admet-441	101	1	thus	thus	ADV
admet-441	101	2	,	,	PUNCT
admet-441	101	3	it	it	PRON
admet-441	101	4	could	could	AUX
admet-441	101	5	successfully	successfully	ADV
admet-441	101	6	describe	describe	VERB
admet-441	101	7	the	the	DET
admet-441	101	8	pk	pk	NOUN
admet-441	101	9	in	in	ADP
admet-441	101	10	plasma	plasma	NOUN
admet-441	101	11	and	and	CCONJ
admet-441	101	12	different	different	ADJ
admet-441	101	13	cns	cns	NOUN
admet-441	101	14	compartments	compartment	NOUN
admet-441	101	15	using	use	VERB
admet-441	101	16	microdialysis	microdialysis	NOUN
admet-441	101	17	data	datum	NOUN
admet-441	101	18	.	.	PUNCT
admet-441	102	1	recently	recently	ADV
admet-441	102	2	,	,	PUNCT
admet-441	102	3	there	there	PRON
admet-441	102	4	has	have	AUX
admet-441	102	5	been	be	AUX
admet-441	102	6	an	an	DET
admet-441	102	7	increasing	increase	VERB
admet-441	102	8	focus	focus	NOUN
admet-441	102	9	on	on	ADP
admet-441	102	10	translational	translational	ADJ
admet-441	102	11	modelling	modelling	NOUN
admet-441	102	12	approaches	approach	NOUN
admet-441	102	13	compared	compare	VERB
admet-441	102	14	to	to	ADP
admet-441	102	15	the	the	DET
admet-441	102	16	traditional	traditional	ADJ
admet-441	102	17	practice	practice	NOUN
admet-441	102	18	of	of	ADP
admet-441	102	19	fitting	fitting	ADJ
admet-441	102	20	model	model	NOUN
admet-441	102	21	parameters	parameter	NOUN
admet-441	102	22	to	to	PART
admet-441	102	23	preclinical	preclinical	VERB
admet-441	102	24	in	in	ADP
admet-441	102	25	vivo	vivo	ADJ
admet-441	102	26	data	datum	NOUN
admet-441	102	27	[	[	X
admet-441	102	28	65	65	NUM
admet-441	102	29	,	,	PUNCT
admet-441	102	30	66	66	NUM
admet-441	102	31	]	]	PUNCT
admet-441	102	32	.	.	PUNCT
admet-441	103	1	ivive	ivive	ADJ
admet-441	103	2	-	-	PUNCT
admet-441	103	3	pbpk	pbpk	ADJ
admet-441	103	4	models	model	NOUN
admet-441	103	5	reported	report	VERB
admet-441	103	6	by	by	ADP
admet-441	103	7	fenneteau	fenneteau	PROPN
admet-441	103	8	et	et	PROPN
admet-441	103	9	al	al	PROPN
admet-441	104	1	[	[	X
admet-441	104	2	67	67	NUM
admet-441	104	3	]	]	PUNCT
admet-441	104	4	and	and	CCONJ
admet-441	104	5	ball	ball	NOUN
admet-441	104	6	et	et	NOUN
admet-441	104	7	al	al	PROPN
admet-441	105	1	[	[	X
admet-441	105	2	68	68	NUM
admet-441	105	3	]	]	PUNCT
admet-441	105	4	demonstrate	demonstrate	NOUN
admet-441	105	5	promising	promise	VERB
admet-441	105	6	examples	example	NOUN
admet-441	105	7	.	.	PUNCT
admet-441	106	1	this	this	DET
admet-441	106	2	review	review	NOUN
admet-441	106	3	has	have	AUX
admet-441	106	4	addressed	address	VERB
admet-441	106	5	imperative	imperative	ADJ
admet-441	106	6	differences	difference	NOUN
admet-441	106	7	among	among	ADP
admet-441	106	8	various	various	ADJ
admet-441	106	9	pbpk	pbpk	ADJ
admet-441	106	10	models	model	NOUN
admet-441	106	11	in	in	ADP
admet-441	106	12	use	use	NOUN
admet-441	106	13	,	,	PUNCT
admet-441	106	14	including	include	VERB
admet-441	106	15	details	detail	NOUN
admet-441	106	16	on	on	ADP
admet-441	106	17	brain	brain	NOUN
admet-441	106	18	compartmentalization	compartmentalization	NOUN
admet-441	106	19	and	and	CCONJ
admet-441	106	20	parameterization	parameterization	NOUN
admet-441	106	21	.	.	PUNCT
admet-441	107	1	the	the	DET
admet-441	107	2	general	general	ADJ
admet-441	107	3	approach	approach	NOUN
admet-441	107	4	of	of	ADP
admet-441	107	5	using	use	VERB
admet-441	107	6	in	in	ADP
admet-441	107	7	vivo	vivo	ADJ
admet-441	107	8	data	datum	NOUN
admet-441	107	9	to	to	PART
admet-441	107	10	obtain	obtain	VERB
admet-441	107	11	drug	drug	NOUN
admet-441	107	12	specific	specific	ADJ
admet-441	107	13	parameters	parameter	NOUN
admet-441	107	14	and	and	CCONJ
admet-441	107	15	physiological	physiological	ADJ
admet-441	107	16	parameter	parameter	NOUN
admet-441	107	17	estimates	estimate	NOUN
admet-441	107	18	by	by	ADP
admet-441	107	19	fitting	fit	VERB
admet-441	107	20	to	to	ADP
admet-441	107	21	in	in	ADP
admet-441	107	22	vivo	vivo	ADJ
admet-441	107	23	data	datum	NOUN
admet-441	107	24	has	have	VERB
admet-441	107	25	poor	poor	ADJ
admet-441	107	26	predictivity	predictivity	NOUN
admet-441	107	27	.	.	PUNCT
admet-441	108	1	similar	similar	ADJ
admet-441	108	2	to	to	ADP
admet-441	108	3	empirical	empirical	ADJ
admet-441	108	4	pbpk	pbpk	NOUN
admet-441	108	5	models	model	NOUN
admet-441	108	6	,	,	PUNCT
admet-441	108	7	the	the	DET
admet-441	108	8	ivive	ivive	ADJ
admet-441	108	9	-	-	PUNCT
admet-441	108	10	pbpk	pbpk	ADJ
admet-441	108	11	model	model	NOUN
admet-441	108	12	uses	use	VERB
admet-441	108	13	a	a	DET
admet-441	108	14	bottom	bottom	ADJ
admet-441	108	15	-	-	PUNCT
admet-441	108	16	up	up	ADP
admet-441	108	17	approach	approach	NOUN
admet-441	108	18	through	through	ADP
admet-441	108	19	ivive	ivive	ADJ
admet-441	108	20	,	,	PUNCT
admet-441	108	21	with	with	ADP
admet-441	108	22	the	the	DET
admet-441	108	23	use	use	NOUN
admet-441	108	24	of	of	ADP
admet-441	108	25	appropriate	appropriate	ADJ
admet-441	108	26	physiological	physiological	ADJ
admet-441	108	27	scaling	scale	VERB
admet-441	108	28	factors	factor	NOUN
admet-441	108	29	.	.	PUNCT
admet-441	109	1	fenneteau	fenneteau	NOUN
admet-441	109	2	and	and	CCONJ
admet-441	109	3	colleagues	colleague	NOUN
admet-441	109	4	scaled	scale	VERB
admet-441	109	5	in	in	ADP
admet-441	109	6	vitro	vitro	X
admet-441	109	7	passive	passive	ADJ
admet-441	109	8	and	and	CCONJ
admet-441	109	9	efflux	efflux	ADJ
admet-441	109	10	permeabilities	permeability	NOUN
admet-441	109	11	of	of	ADP
admet-441	109	12	domperidone	domperidone	NOUN
admet-441	109	13	to	to	PART
admet-441	109	14	in	in	ADP
admet-441	109	15	vivo	vivo	ADJ
admet-441	109	16	pankajini	pankajini	PROPN
admet-441	109	17	mallick	mallick	PROPN
admet-441	109	18	admet	admet	PROPN
admet-441	109	19	&	&	CCONJ
admet-441	109	20	dmpk	dmpk	PROPN
admet-441	109	21	5(4	5(4	NOUN
admet-441	109	22	)	)	PUNCT
admet-441	109	23	(	(	PUNCT
admet-441	109	24	2017	2017	NUM
admet-441	109	25	)	)	PUNCT
admet-441	109	26	201	201	NUM
admet-441	109	27	-	-	SYM
admet-441	109	28	211	211	NUM
admet-441	109	29	206	206	NUM
admet-441	109	30	intrinsic	intrinsic	ADJ
admet-441	109	31	permeabilities	permeability	NOUN
admet-441	109	32	,	,	PUNCT
admet-441	109	33	and	and	CCONJ
admet-441	109	34	then	then	ADV
admet-441	109	35	using	use	VERB
admet-441	109	36	literature	literature	NOUN
admet-441	109	37	-	-	PUNCT
admet-441	109	38	based	base	VERB
admet-441	109	39	physiological	physiological	ADJ
admet-441	109	40	values	value	NOUN
admet-441	109	41	for	for	ADP
admet-441	109	42	in	in	ADP
admet-441	109	43	vivo	vivo	ADJ
admet-441	109	44	membrane	membrane	NOUN
admet-441	109	45	surface	surface	NOUN
admet-441	109	46	area	area	NOUN
admet-441	109	47	,	,	PUNCT
admet-441	109	48	they	they	PRON
admet-441	109	49	further	far	ADV
admet-441	109	50	scaled	scale	VERB
admet-441	109	51	the	the	DET
admet-441	109	52	permeabilities	permeability	NOUN
admet-441	109	53	to	to	ADP
admet-441	109	54	whole	whole	ADJ
admet-441	109	55	organ	organ	NOUN
admet-441	109	56	permeabilities	permeability	NOUN
admet-441	110	1	[	[	X
admet-441	110	2	67	67	NUM
admet-441	110	3	]	]	PUNCT
admet-441	110	4	.	.	PUNCT
admet-441	111	1	the	the	DET
admet-441	111	2	in	in	ADV
admet-441	111	3	vitro	vitro	X
admet-441	111	4	intrinsic	intrinsic	ADJ
admet-441	111	5	p	p	NOUN
admet-441	111	6	-	-	PUNCT
admet-441	111	7	gp	gp	NOUN
admet-441	111	8	efflux	efflux	NOUN
admet-441	111	9	permeability	permeability	NOUN
admet-441	111	10	determined	determine	VERB
admet-441	111	11	in	in	ADP
admet-441	111	12	caco-2	caco-2	NUM
admet-441	111	13	cells	cell	NOUN
admet-441	111	14	was	be	AUX
admet-441	111	15	corrected	correct	VERB
admet-441	111	16	using	use	VERB
admet-441	111	17	the	the	DET
admet-441	111	18	relative	relative	ADJ
admet-441	111	19	fraction	fraction	NOUN
admet-441	111	20	of	of	ADP
admet-441	111	21	mdr1a/1b	mdr1a/1b	PROPN
admet-441	111	22	messenger	messenger	NOUN
admet-441	111	23	rna	rna	NOUN
admet-441	111	24	expression	expression	NOUN
admet-441	111	25	measured	measure	VERB
admet-441	111	26	in	in	ADP
admet-441	111	27	the	the	DET
admet-441	111	28	brain	brain	NOUN
admet-441	111	29	compared	compare	VERB
admet-441	111	30	to	to	ADP
admet-441	111	31	that	that	PRON
admet-441	111	32	in	in	ADP
admet-441	111	33	the	the	DET
admet-441	111	34	intestine	intestine	NOUN
admet-441	111	35	.	.	PUNCT
admet-441	112	1	two	two	NUM
admet-441	112	2	methods	method	NOUN
admet-441	112	3	of	of	ADP
admet-441	112	4	ivive	ivive	ADJ
admet-441	112	5	used	use	VERB
admet-441	112	6	for	for	ADP
admet-441	112	7	pbpk	pbpk	NOUN
admet-441	112	8	modelling	modelling	NOUN
admet-441	112	9	of	of	ADP
admet-441	112	10	morphine	morphine	NOUN
admet-441	112	11	and	and	CCONJ
admet-441	112	12	oxycodone	oxycodone	NOUN
admet-441	112	13	describe	describe	VERB
admet-441	112	14	different	different	ADJ
admet-441	112	15	strategies	strategy	NOUN
admet-441	112	16	for	for	ADP
admet-441	112	17	ivive	ivive	ADJ
admet-441	112	18	of	of	ADP
admet-441	112	19	drug	drug	NOUN
admet-441	112	20	transporters	transporter	NOUN
admet-441	112	21	at	at	ADP
admet-441	112	22	the	the	DET
admet-441	112	23	bbb	bbb	PROPN
admet-441	112	24	,	,	PUNCT
admet-441	112	25	which	which	PRON
admet-441	112	26	can	can	AUX
admet-441	112	27	be	be	AUX
admet-441	112	28	used	use	VERB
admet-441	112	29	in	in	ADP
admet-441	112	30	different	different	ADJ
admet-441	112	31	phases	phase	NOUN
admet-441	112	32	of	of	ADP
admet-441	112	33	drug	drug	NOUN
admet-441	112	34	development	development	NOUN
admet-441	112	35	[	[	X
admet-441	112	36	69	69	NUM
admet-441	112	37	]	]	PUNCT
admet-441	112	38	.	.	PUNCT
admet-441	113	1	the	the	DET
admet-441	113	2	morphine	morphine	NOUN
admet-441	113	3	ivive	ivive	ADJ
admet-441	113	4	-	-	PUNCT
admet-441	113	5	pbpk	pbpk	ADJ
admet-441	113	6	model	model	NOUN
admet-441	113	7	was	be	AUX
admet-441	113	8	based	base	VERB
admet-441	113	9	on	on	ADP
admet-441	113	10	data	datum	NOUN
admet-441	113	11	from	from	ADP
admet-441	113	12	in	in	ADP
admet-441	113	13	vitro	vitro	X
admet-441	113	14	caco-2	caco-2	NUM
admet-441	113	15	permeability	permeability	NOUN
admet-441	113	16	and	and	CCONJ
admet-441	113	17	in	in	ADP
admet-441	113	18	vivo	vivo	ADJ
admet-441	113	19	total	total	ADJ
admet-441	113	20	concentrations	concentration	NOUN
admet-441	113	21	in	in	ADP
admet-441	113	22	brain	brain	NOUN
admet-441	113	23	homogenate	homogenate	NOUN
admet-441	113	24	.	.	PUNCT
admet-441	114	1	on	on	ADP
admet-441	114	2	the	the	DET
admet-441	114	3	other	other	ADJ
admet-441	114	4	hand	hand	NOUN
admet-441	114	5	,	,	PUNCT
admet-441	114	6	the	the	DET
admet-441	114	7	oxycodone	oxycodone	NOUN
admet-441	114	8	ivive	ivive	ADJ
admet-441	114	9	-	-	PUNCT
admet-441	114	10	pbpk	pbpk	ADJ
admet-441	114	11	model	model	NOUN
admet-441	114	12	used	use	VERB
admet-441	114	13	data	datum	NOUN
admet-441	114	14	from	from	ADP
admet-441	114	15	complicated	complicated	ADJ
admet-441	114	16	experiments	experiment	NOUN
admet-441	114	17	generally	generally	ADV
admet-441	114	18	performed	perform	VERB
admet-441	114	19	in	in	ADP
admet-441	114	20	later	later	ADJ
admet-441	114	21	stage	stage	NOUN
admet-441	114	22	of	of	ADP
admet-441	114	23	drug	drug	NOUN
admet-441	114	24	development	development	NOUN
admet-441	114	25	,	,	PUNCT
admet-441	114	26	which	which	PRON
admet-441	114	27	included	include	VERB
admet-441	114	28	in	in	ADP
admet-441	114	29	vivo	vivo	ADJ
admet-441	114	30	unbound	unbound	NOUN
admet-441	114	31	extracelluar	extracelluar	ADJ
admet-441	114	32	fraction	fraction	NOUN
admet-441	114	33	(	(	PUNCT
admet-441	114	34	ecf	ecf	PROPN
admet-441	114	35	)	)	PUNCT
admet-441	114	36	concentrations	concentration	NOUN
admet-441	114	37	obtained	obtain	VERB
admet-441	114	38	from	from	ADP
admet-441	114	39	microdialysis	microdialysis	NOUN
admet-441	114	40	and	and	CCONJ
admet-441	114	41	in	in	ADP
admet-441	114	42	vitro	vitro	X
admet-441	114	43	uptake	uptake	ADJ
admet-441	114	44	kinetics	kinetic	NOUN
admet-441	114	45	in	in	ADP
admet-441	114	46	rat	rat	NOUN
admet-441	114	47	brain	brain	NOUN
admet-441	114	48	microvessel	microvessel	NOUN
admet-441	114	49	endothelial	endothelial	ADJ
admet-441	114	50	cells	cell	NOUN
admet-441	114	51	.	.	PUNCT
admet-441	115	1	relative	relative	ADJ
admet-441	115	2	activity	activity	NOUN
admet-441	115	3	factor	factor	NOUN
admet-441	115	4	(	(	PUNCT
admet-441	115	5	raf	raf	PROPN
admet-441	115	6	)	)	PUNCT
admet-441	115	7	was	be	AUX
admet-441	115	8	used	use	VERB
admet-441	115	9	to	to	PART
admet-441	115	10	account	account	VERB
admet-441	115	11	for	for	ADP
admet-441	115	12	the	the	DET
admet-441	115	13	difference	difference	NOUN
admet-441	115	14	between	between	ADP
admet-441	115	15	in	in	ADP
admet-441	115	16	vitro	vitro	X
admet-441	115	17	and	and	CCONJ
admet-441	115	18	in	in	ADP
admet-441	115	19	vivo	vivo	ADJ
admet-441	115	20	data	datum	NOUN
admet-441	115	21	.	.	PUNCT
admet-441	116	1	since	since	SCONJ
admet-441	116	2	it	it	PRON
admet-441	116	3	is	be	AUX
admet-441	116	4	very	very	ADV
admet-441	116	5	difficult	difficult	ADJ
admet-441	116	6	to	to	PART
admet-441	116	7	obtain	obtain	VERB
admet-441	116	8	human	human	ADJ
admet-441	116	9	brain	brain	NOUN
admet-441	116	10	homogenate	homogenate	NOUN
admet-441	116	11	or	or	CCONJ
admet-441	116	12	primary	primary	ADJ
admet-441	116	13	brain	brain	NOUN
admet-441	116	14	endothelial	endothelial	NOUN
admet-441	116	15	cells	cell	NOUN
admet-441	116	16	from	from	ADP
admet-441	116	17	isolated	isolated	ADJ
admet-441	116	18	microvessels	microvessel	NOUN
admet-441	116	19	,	,	PUNCT
admet-441	116	20	determination	determination	NOUN
admet-441	116	21	of	of	ADP
admet-441	116	22	drug	drug	NOUN
admet-441	116	23	-	-	PUNCT
admet-441	116	24	specific	specific	ADJ
admet-441	116	25	parameters	parameter	NOUN
admet-441	116	26	from	from	ADP
admet-441	116	27	in	in	ADP
admet-441	116	28	vitro	vitro	X
admet-441	116	29	systems	system	NOUN
admet-441	116	30	of	of	ADP
admet-441	116	31	human	human	ADJ
admet-441	116	32	origin	origin	NOUN
admet-441	116	33	is	be	AUX
admet-441	116	34	not	not	PART
admet-441	116	35	always	always	ADV
admet-441	116	36	feasible	feasible	ADJ
admet-441	116	37	.	.	PUNCT
admet-441	117	1	brain	brain	NOUN
admet-441	117	2	microdialysis	microdialysis	NOUN
admet-441	117	3	and	and	CCONJ
admet-441	117	4	cerebrospinal	cerebrospinal	ADJ
admet-441	117	5	fluid	fluid	NOUN
admet-441	117	6	(	(	PUNCT
admet-441	117	7	csf	csf	NOUN
admet-441	117	8	)	)	PUNCT
admet-441	117	9	sampling	sample	VERB
admet-441	117	10	is	be	AUX
admet-441	117	11	another	another	DET
admet-441	117	12	approach	approach	NOUN
admet-441	117	13	to	to	PART
admet-441	117	14	determine	determine	VERB
admet-441	117	15	drug	drug	NOUN
admet-441	117	16	pharmacokinetics	pharmacokinetic	NOUN
admet-441	117	17	,	,	PUNCT
admet-441	117	18	but	but	CCONJ
admet-441	117	19	due	due	ADP
admet-441	117	20	to	to	ADP
admet-441	117	21	the	the	DET
admet-441	117	22	invasive	invasive	ADJ
admet-441	117	23	nature	nature	NOUN
admet-441	117	24	of	of	ADP
admet-441	117	25	these	these	DET
admet-441	117	26	techniques	technique	NOUN
admet-441	117	27	,	,	PUNCT
admet-441	117	28	they	they	PRON
admet-441	117	29	are	be	AUX
admet-441	117	30	only	only	ADV
admet-441	117	31	carried	carry	VERB
admet-441	117	32	out	out	ADP
admet-441	117	33	on	on	ADP
admet-441	117	34	diseased	diseased	ADJ
admet-441	117	35	patients	patient	NOUN
admet-441	117	36	[	[	X
admet-441	117	37	70	70	NUM
admet-441	117	38	]	]	PUNCT
admet-441	117	39	,	,	PUNCT
admet-441	117	40	which	which	PRON
admet-441	117	41	introduces	introduce	VERB
admet-441	117	42	significant	significant	ADJ
admet-441	117	43	challenges	challenge	NOUN
admet-441	117	44	for	for	ADP
admet-441	117	45	the	the	DET
admet-441	117	46	evaluation	evaluation	NOUN
admet-441	117	47	of	of	ADP
admet-441	117	48	model	model	NOUN
admet-441	117	49	predictions	prediction	NOUN
admet-441	117	50	with	with	ADP
admet-441	117	51	the	the	DET
admet-441	117	52	human	human	ADJ
admet-441	117	53	cns	cns	PROPN
admet-441	117	54	pbpk	pbpk	PROPN
admet-441	117	55	model	model	NOUN
admet-441	117	56	.	.	PUNCT
admet-441	118	1	linking	link	VERB
admet-441	118	2	pbpk	pbpk	ADJ
admet-441	118	3	/	/	SYM
admet-441	118	4	pd	pd	NOUN
admet-441	118	5	models	model	NOUN
admet-441	118	6	to	to	ADP
admet-441	118	7	biomarkers	biomarker	NOUN
admet-441	118	8	or	or	CCONJ
admet-441	118	9	observed	observe	VERB
admet-441	118	10	in	in	ADP
admet-441	118	11	vivo	vivo	ADJ
admet-441	118	12	pharmacodynamics	pharmacodynamic	NOUN
admet-441	118	13	are	be	AUX
admet-441	118	14	alternative	alternative	ADJ
admet-441	118	15	approaches	approach	NOUN
admet-441	118	16	to	to	PART
admet-441	118	17	evaluate	evaluate	VERB
admet-441	118	18	human	human	ADJ
admet-441	118	19	cns	cns	NOUN
admet-441	118	20	pbpk	pbpk	NOUN
admet-441	118	21	predictions	prediction	NOUN
admet-441	118	22	.	.	PUNCT
admet-441	119	1	however	however	ADV
admet-441	119	2	,	,	PUNCT
admet-441	119	3	the	the	DET
admet-441	119	4	success	success	NOUN
admet-441	119	5	of	of	ADP
admet-441	119	6	these	these	DET
admet-441	119	7	approaches	approach	NOUN
admet-441	119	8	depends	depend	VERB
admet-441	119	9	on	on	ADP
admet-441	119	10	selection	selection	NOUN
admet-441	119	11	of	of	ADP
admet-441	119	12	appropriate	appropriate	ADJ
admet-441	119	13	biomarkers	biomarker	NOUN
admet-441	119	14	and	and	CCONJ
admet-441	119	15	the	the	DET
admet-441	119	16	establishment	establishment	NOUN
admet-441	119	17	of	of	ADP
admet-441	119	18	a	a	DET
admet-441	119	19	reliable	reliable	ADJ
admet-441	119	20	pk	pk	NOUN
admet-441	119	21	/	/	SYM
admet-441	119	22	pd	pd	PROPN
admet-441	119	23	relationship	relationship	NOUN
admet-441	119	24	.	.	PUNCT
admet-441	120	1	thus	thus	ADV
admet-441	120	2	,	,	PUNCT
admet-441	120	3	there	there	PRON
admet-441	120	4	is	be	VERB
admet-441	120	5	need	need	NOUN
admet-441	120	6	for	for	SCONJ
admet-441	120	7	more	more	ADV
admet-441	120	8	ivive	ivive	ADJ
admet-441	120	9	-	-	PUNCT
admet-441	120	10	pbpk	pbpk	ADJ
admet-441	120	11	models	model	NOUN
admet-441	120	12	to	to	PART
admet-441	120	13	fully	fully	ADV
admet-441	120	14	explore	explore	VERB
admet-441	120	15	and	and	CCONJ
admet-441	120	16	evaluate	evaluate	VERB
admet-441	120	17	their	their	PRON
admet-441	120	18	applicability	applicability	NOUN
admet-441	120	19	for	for	ADP
admet-441	120	20	the	the	DET
admet-441	120	21	prediction	prediction	NOUN
admet-441	120	22	of	of	ADP
admet-441	120	23	drug	drug	NOUN
admet-441	120	24	pharmacokinetics	pharmacokinetic	NOUN
admet-441	120	25	in	in	ADP
admet-441	120	26	the	the	DET
admet-441	120	27	brain	brain	NOUN
admet-441	120	28	.	.	PUNCT
admet-441	121	1	ivive	ivive	ADJ
admet-441	121	2	-	-	PUNCT
admet-441	121	3	pbpk	pbpk	ADJ
admet-441	121	4	model	model	NOUN
admet-441	121	5	for	for	ADP
admet-441	121	6	transporter	transporter	NOUN
admet-441	121	7	mediated	mediate	VERB
admet-441	121	8	drug	drug	NOUN
admet-441	121	9	-	-	PUNCT
admet-441	121	10	drug	drug	NOUN
admet-441	121	11	interaction	interaction	NOUN
admet-441	121	12	traditional	traditional	ADJ
admet-441	121	13	pharmacokinetic	pharmacokinetic	ADJ
admet-441	121	14	modeling	modeling	NOUN
admet-441	121	15	lacks	lack	VERB
admet-441	121	16	good	good	ADJ
admet-441	121	17	predictability	predictability	NOUN
admet-441	121	18	for	for	ADP
admet-441	121	19	complex	complex	ADJ
admet-441	121	20	drug	drug	NOUN
admet-441	121	21	-	-	PUNCT
admet-441	121	22	drug	drug	NOUN
admet-441	121	23	interactions	interaction	NOUN
admet-441	121	24	(	(	PUNCT
admet-441	121	25	ddis	ddi	NOUN
admet-441	121	26	)	)	PUNCT
admet-441	121	27	because	because	SCONJ
admet-441	121	28	in	in	ADP
admet-441	121	29	most	most	ADJ
admet-441	121	30	cases	case	NOUN
admet-441	121	31	,	,	PUNCT
admet-441	121	32	only	only	ADV
admet-441	121	33	in	in	ADP
admet-441	121	34	vitro	vitro	X
admet-441	121	35	and	and	CCONJ
admet-441	121	36	limited	limited	ADJ
admet-441	121	37	clinical	clinical	ADJ
admet-441	121	38	data	datum	NOUN
admet-441	121	39	are	be	AUX
admet-441	121	40	available	available	ADJ
admet-441	121	41	in	in	ADP
admet-441	121	42	early	early	ADJ
admet-441	121	43	drug	drug	NOUN
admet-441	121	44	development	development	NOUN
admet-441	121	45	.	.	PUNCT
admet-441	122	1	as	as	SCONJ
admet-441	122	2	ivive	ivive	ADJ
admet-441	122	3	-	-	PUNCT
admet-441	122	4	pbpk	pbpk	ADJ
admet-441	122	5	enables	enable	VERB
admet-441	122	6	scaling	scaling	NOUN
admet-441	122	7	of	of	ADP
admet-441	122	8	early	early	ADV
admet-441	122	9	in	in	ADP
admet-441	122	10	vitro	vitro	X
admet-441	122	11	and	and	CCONJ
admet-441	122	12	animal	animal	NOUN
admet-441	122	13	data	datum	NOUN
admet-441	122	14	for	for	ADP
admet-441	122	15	human	human	ADJ
admet-441	122	16	predictions	prediction	NOUN
admet-441	122	17	,	,	PUNCT
admet-441	122	18	it	it	PRON
admet-441	122	19	can	can	AUX
admet-441	122	20	aid	aid	VERB
admet-441	122	21	ddi	ddi	PROPN
admet-441	122	22	risk	risk	NOUN
admet-441	122	23	assessment	assessment	NOUN
admet-441	122	24	.	.	PUNCT
admet-441	123	1	the	the	DET
admet-441	123	2	effect	effect	NOUN
admet-441	123	3	of	of	ADP
admet-441	123	4	transporter	transporter	NOUN
admet-441	123	5	-	-	PUNCT
admet-441	123	6	enzyme	enzyme	NOUN
admet-441	123	7	interplay	interplay	NOUN
admet-441	123	8	on	on	ADP
admet-441	123	9	drug	drug	NOUN
admet-441	123	10	bioavailability	bioavailability	NOUN
admet-441	123	11	and	and	CCONJ
admet-441	123	12	hepatic	hepatic	ADJ
admet-441	123	13	disposition	disposition	NOUN
admet-441	123	14	is	be	AUX
admet-441	123	15	well	well	ADV
admet-441	123	16	recognized	recognize	VERB
admet-441	123	17	[	[	X
admet-441	123	18	71	71	NUM
admet-441	123	19	,	,	PUNCT
admet-441	123	20	72].there	72].there	NUM
admet-441	123	21	are	be	AUX
admet-441	123	22	examples	example	NOUN
admet-441	123	23	of	of	ADP
admet-441	123	24	the	the	DET
admet-441	123	25	involvement	involvement	NOUN
admet-441	123	26	of	of	ADP
admet-441	123	27	transporter	transporter	NOUN
admet-441	123	28	-	-	PUNCT
admet-441	123	29	enzyme	enzyme	NOUN
admet-441	123	30	interplay	interplay	NOUN
admet-441	123	31	in	in	ADP
admet-441	123	32	ddis	ddis	NOUN
admet-441	123	33	.	.	PUNCT
admet-441	124	1	lau	lau	PROPN
admet-441	124	2	et	et	PROPN
admet-441	124	3	al	al	PROPN
admet-441	124	4	reported	report	VERB
admet-441	124	5	that	that	SCONJ
admet-441	124	6	the	the	DET
admet-441	124	7	inhibitory	inhibitory	ADJ
admet-441	124	8	effect	effect	NOUN
admet-441	124	9	of	of	ADP
admet-441	124	10	rifampin	rifampin	NOUN
admet-441	124	11	on	on	ADP
admet-441	124	12	atorvastatin	atorvastatin	NOUN
admet-441	124	13	kinetics	kinetic	NOUN
admet-441	124	14	involves	involve	VERB
admet-441	124	15	transporter	transporter	NOUN
admet-441	124	16	-	-	PUNCT
admet-441	124	17	enzyme	enzyme	NOUN
admet-441	124	18	interplay	interplay	NOUN
admet-441	124	19	[	[	X
admet-441	124	20	73	73	NUM
admet-441	124	21	]	]	PUNCT
admet-441	124	22	.	.	PUNCT
admet-441	125	1	rifampin	rifampin	PROPN
admet-441	125	2	is	be	AUX
admet-441	125	3	a	a	DET
admet-441	125	4	potent	potent	ADJ
admet-441	125	5	inhibitor	inhibitor	NOUN
admet-441	125	6	of	of	ADP
admet-441	125	7	organic	organic	ADJ
admet-441	125	8	anion	anion	NOUN
admet-441	125	9	-	-	PUNCT
admet-441	125	10	transporting	transport	VERB
admet-441	125	11	polypeptide	polypeptide	ADJ
admet-441	125	12	(	(	PUNCT
admet-441	125	13	oatp	oatp	ADJ
admet-441	125	14	)	)	PUNCT
admet-441	125	15	transporters	transporter	NOUN
admet-441	125	16	and	and	CCONJ
admet-441	125	17	atorvastatin	atorvastatin	NOUN
admet-441	125	18	is	be	AUX
admet-441	125	19	primarily	primarily	ADV
admet-441	125	20	metabolized	metabolize	VERB
admet-441	125	21	by	by	ADP
admet-441	125	22	cyp3a	cyp3a	NOUN
admet-441	125	23	in	in	ADP
admet-441	125	24	the	the	DET
admet-441	125	25	liver	liver	NOUN
admet-441	125	26	,	,	PUNCT
admet-441	125	27	via	via	ADP
admet-441	125	28	its	its	PRON
admet-441	125	29	lactone	lactone	NOUN
admet-441	125	30	group	group	NOUN
admet-441	125	31	.	.	PUNCT
admet-441	126	1	in	in	ADP
admet-441	126	2	the	the	DET
admet-441	126	3	study	study	NOUN
admet-441	126	4	by	by	ADP
admet-441	126	5	lau	lau	PROPN
admet-441	126	6	et	et	PROPN
admet-441	126	7	al	al	PROPN
admet-441	127	1	[	[	X
admet-441	127	2	73	73	NUM
admet-441	127	3	]	]	PUNCT
admet-441	127	4	,	,	PUNCT
admet-441	127	5	rifampin	rifampin	NOUN
admet-441	127	6	demonstrated	demonstrate	VERB
admet-441	127	7	inhibition	inhibition	NOUN
admet-441	127	8	of	of	ADP
admet-441	127	9	atorvastatin	atorvastatin	NOUN
admet-441	127	10	uptake	uptake	ADJ
admet-441	127	11	into	into	ADP
admet-441	127	12	the	the	DET
admet-441	127	13	liver	liver	NOUN
admet-441	127	14	and	and	CCONJ
admet-441	127	15	a	a	DET
admet-441	127	16	change	change	NOUN
admet-441	127	17	in	in	ADP
admet-441	127	18	the	the	DET
admet-441	127	19	ratio	ratio	NOUN
admet-441	127	20	of	of	ADP
admet-441	127	21	atorvastatin	atorvastatin	PROPN
admet-441	127	22	lactone	lactone	PROPN
admet-441	127	23	to	to	ADP
admet-441	127	24	atorvastatin	atorvastatin	PROPN
admet-441	127	25	acid	acid	PROPN
admet-441	127	26	,	,	PUNCT
admet-441	127	27	thereby	thereby	ADV
admet-441	127	28	changing	change	VERB
admet-441	127	29	the	the	DET
admet-441	127	30	amount	amount	NOUN
admet-441	127	31	of	of	ADP
admet-441	127	32	substrate	substrate	NOUN
admet-441	127	33	available	available	ADJ
admet-441	127	34	to	to	ADP
admet-441	127	35	the	the	DET
admet-441	127	36	enzymes	enzyme	NOUN
admet-441	127	37	in	in	ADP
admet-441	127	38	the	the	DET
admet-441	127	39	liver	liver	NOUN
admet-441	127	40	.	.	PUNCT
admet-441	128	1	grillo	grillo	PROPN
admet-441	128	2	et	et	PROPN
admet-441	129	1	al	al	PROPN
admet-441	130	1	[	[	X
admet-441	130	2	74	74	NUM
admet-441	130	3	]	]	PUNCT
admet-441	130	4	demonstrated	demonstrate	VERB
admet-441	130	5	the	the	DET
admet-441	130	6	use	use	NOUN
admet-441	130	7	of	of	ADP
admet-441	130	8	ivive	ivive	ADJ
admet-441	130	9	-	-	PUNCT
admet-441	130	10	pbpk	pbpk	ADJ
admet-441	130	11	modeling	modeling	NOUN
admet-441	130	12	to	to	PART
admet-441	130	13	predict	predict	VERB
admet-441	130	14	potential	potential	ADJ
admet-441	130	15	clinically	clinically	ADV
admet-441	130	16	relevant	relevant	ADJ
admet-441	130	17	ddi	ddi	NOUN
admet-441	130	18	between	between	ADP
admet-441	130	19	rivaroxaban	rivaroxaban	NOUN
admet-441	130	20	and	and	CCONJ
admet-441	130	21	a	a	DET
admet-441	130	22	combination	combination	NOUN
admet-441	130	23	of	of	ADP
admet-441	130	24	p	p	NOUN
admet-441	130	25	-	-	PUNCT
admet-441	130	26	gp	gp	NOUN
admet-441	130	27	and	and	CCONJ
admet-441	130	28	a	a	DET
admet-441	130	29	moderate	moderate	ADJ
admet-441	130	30	cyp3a4	cyp3a4	NOUN
admet-441	130	31	inhibitor	inhibitor	NOUN
admet-441	130	32	in	in	ADP
admet-441	130	33	renal	renal	ADJ
admet-441	130	34	impaired	impaired	ADJ
admet-441	130	35	patients	patient	NOUN
admet-441	130	36	.	.	PUNCT
admet-441	131	1	thus	thus	ADV
admet-441	131	2	,	,	PUNCT
admet-441	131	3	bottom	bottom	ADJ
admet-441	131	4	-	-	PUNCT
admet-441	131	5	up	up	ADP
admet-441	131	6	pbpk	pbpk	NOUN
admet-441	131	7	models	model	NOUN
admet-441	131	8	are	be	AUX
admet-441	131	9	a	a	DET
admet-441	131	10	powerful	powerful	ADJ
admet-441	131	11	tool	tool	NOUN
admet-441	131	12	for	for	ADP
admet-441	131	13	the	the	DET
admet-441	131	14	prediction	prediction	NOUN
admet-441	131	15	of	of	ADP
admet-441	131	16	transporter	transporter	NOUN
admet-441	131	17	-	-	PUNCT
admet-441	131	18	mediated	mediate	VERB
admet-441	131	19	drug	drug	NOUN
admet-441	131	20	interactions	interaction	NOUN
admet-441	131	21	,	,	PUNCT
admet-441	131	22	and	and	CCONJ
admet-441	131	23	accurate	accurate	ADJ
admet-441	131	24	quantitation	quantitation	NOUN
admet-441	131	25	of	of	ADP
admet-441	131	26	protein	protein	NOUN
admet-441	131	27	concentrations	concentration	NOUN
admet-441	131	28	in	in	ADV
admet-441	131	29	in	in	ADP
admet-441	131	30	vitro	vitro	X
admet-441	131	31	and	and	CCONJ
admet-441	131	32	in	in	ADP
admet-441	131	33	vivo	vivo	ADJ
admet-441	131	34	systems	system	NOUN
admet-441	131	35	will	will	AUX
admet-441	131	36	further	far	ADV
admet-441	131	37	enhance	enhance	VERB
admet-441	131	38	their	their	PRON
admet-441	131	39	accuracy	accuracy	NOUN
admet-441	131	40	.	.	PUNCT
admet-441	132	1	given	give	VERB
admet-441	132	2	that	that	SCONJ
admet-441	132	3	in	in	ADP
admet-441	132	4	vitro	vitro	X
admet-441	132	5	systems	system	NOUN
admet-441	132	6	do	do	AUX
admet-441	132	7	not	not	PART
admet-441	132	8	completely	completely	ADV
admet-441	132	9	reproduce	reproduce	VERB
admet-441	132	10	the	the	DET
admet-441	132	11	transport	transport	NOUN
admet-441	132	12	rates	rate	NOUN
admet-441	132	13	and	and	CCONJ
admet-441	132	14	affinities	affinity	NOUN
admet-441	132	15	like	like	ADP
admet-441	132	16	in	in	ADP
admet-441	132	17	vivo	vivo	NOUN
admet-441	132	18	,	,	PUNCT
admet-441	132	19	the	the	DET
admet-441	132	20	middle	middle	NOUN
admet-441	132	21	out	out	ADP
admet-441	132	22	parameter	parameter	NOUN
admet-441	132	23	optimization	optimization	NOUN
admet-441	132	24	approach	approach	NOUN
admet-441	132	25	is	be	AUX
admet-441	132	26	a	a	DET
admet-441	132	27	necessary	necessary	ADJ
admet-441	132	28	step	step	NOUN
admet-441	132	29	in	in	ADP
admet-441	132	30	model	model	NOUN
admet-441	132	31	verification	verification	NOUN
admet-441	132	32	.	.	PUNCT
admet-441	133	1	conclusions	conclusion	NOUN
admet-441	133	2	ivive	ivive	ADJ
admet-441	133	3	requires	require	VERB
admet-441	133	4	information	information	NOUN
admet-441	133	5	from	from	ADP
admet-441	133	6	numerous	numerous	ADJ
admet-441	133	7	processes	process	NOUN
admet-441	133	8	and	and	CCONJ
admet-441	133	9	organs	organ	NOUN
admet-441	133	10	.	.	PUNCT
admet-441	134	1	each	each	PRON
admet-441	134	2	has	have	VERB
admet-441	134	3	its	its	PRON
admet-441	134	4	advantages	advantage	NOUN
admet-441	134	5	and	and	CCONJ
admet-441	134	6	limitations	limitation	NOUN
admet-441	134	7	in	in	ADP
admet-441	134	8	translating	translate	VERB
admet-441	134	9	data	datum	NOUN
admet-441	134	10	to	to	ADP
admet-441	134	11	the	the	DET
admet-441	134	12	clinic	clinic	NOUN
admet-441	134	13	.	.	PUNCT
admet-441	135	1	ivive	ivive	ADJ
admet-441	135	2	-	-	PUNCT
admet-441	135	3	pbpk	pbpk	ADJ
admet-441	135	4	modeling	modeling	NOUN
admet-441	135	5	is	be	AUX
admet-441	135	6	a	a	DET
admet-441	135	7	powerful	powerful	ADJ
admet-441	135	8	approach	approach	NOUN
admet-441	135	9	when	when	SCONJ
admet-441	135	10	full	full	ADJ
admet-441	135	11	kinetic	kinetic	ADJ
admet-441	135	12	admet	admet	NOUN
admet-441	135	13	&	&	CCONJ
admet-441	135	14	dmpk	dmpk	PROPN
admet-441	135	15	5(4	5(4	NOUN
admet-441	135	16	)	)	PUNCT
admet-441	135	17	(	(	PUNCT
admet-441	135	18	2017	2017	NUM
admet-441	135	19	)	)	PUNCT
admet-441	135	20	201	201	NUM
admet-441	135	21	-	-	SYM
admet-441	135	22	211	211	NUM
admet-441	135	23	utilizing	utilize	VERB
admet-441	135	24	in	in	ADP
admet-441	135	25	vitro	vitro	X
admet-441	135	26	transporter	transporter	NOUN
admet-441	135	27	data	datum	NOUN
admet-441	135	28	in	in	ADP
admet-441	135	29	ivive	ivive	ADJ
admet-441	135	30	-	-	PUNCT
admet-441	135	31	pbpk	pbpk	ADJ
admet-441	135	32	doi	doi	NOUN
admet-441	135	33	:	:	PUNCT
admet-441	135	34	10.5599	10.5599	NUM
admet-441	135	35	/	/	SYM
admet-441	135	36	admet.5.4.441	admet.5.4.441	NOUN
admet-441	135	37	207	207	NUM
admet-441	135	38	characterization	characterization	NOUN
admet-441	135	39	of	of	ADP
admet-441	135	40	transporters	transporter	NOUN
admet-441	135	41	is	be	AUX
admet-441	135	42	implemented	implement	VERB
admet-441	135	43	.	.	PUNCT
admet-441	136	1	thus	thus	ADV
admet-441	136	2	,	,	PUNCT
admet-441	136	3	understanding	understand	VERB
admet-441	136	4	the	the	DET
admet-441	136	5	influence	influence	NOUN
admet-441	136	6	of	of	ADP
admet-441	136	7	drug	drug	NOUN
admet-441	136	8	transporters	transporter	NOUN
admet-441	136	9	on	on	ADP
admet-441	136	10	drug	drug	NOUN
admet-441	136	11	pharmacokinetics	pharmacokinetic	NOUN
admet-441	136	12	can	can	AUX
admet-441	136	13	be	be	AUX
admet-441	136	14	obtained	obtain	VERB
admet-441	136	15	through	through	ADP
admet-441	136	16	a	a	DET
admet-441	136	17	combination	combination	NOUN
admet-441	136	18	of	of	ADP
admet-441	136	19	approaches	approach	NOUN
admet-441	136	20	.	.	PUNCT
admet-441	137	1	the	the	DET
admet-441	137	2	future	future	NOUN
admet-441	137	3	of	of	ADP
admet-441	137	4	drug	drug	NOUN
admet-441	137	5	transporter	transporter	NOUN
admet-441	137	6	-	-	PUNCT
admet-441	137	7	based	base	VERB
admet-441	137	8	ivive	ivive	ADJ
admet-441	137	9	-	-	PUNCT
admet-441	137	10	pbpk	pbpk	ADJ
admet-441	137	11	models	model	NOUN
admet-441	137	12	lies	lie	VERB
admet-441	137	13	in	in	ADP
admet-441	137	14	their	their	PRON
admet-441	137	15	potential	potential	NOUN
admet-441	137	16	to	to	PART
admet-441	137	17	contribute	contribute	VERB
admet-441	137	18	to	to	ADP
admet-441	137	19	pharmacogenetic	pharmacogenetic	ADJ
admet-441	137	20	studies	study	NOUN
admet-441	137	21	.	.	PUNCT
admet-441	138	1	drug	drug	NOUN
admet-441	138	2	transporters	transporter	NOUN
admet-441	138	3	and	and	CCONJ
admet-441	138	4	metabolizing	metabolize	VERB
admet-441	138	5	enzymes	enzyme	NOUN
admet-441	138	6	differ	differ	VERB
admet-441	138	7	significantly	significantly	ADV
admet-441	138	8	based	base	VERB
admet-441	138	9	on	on	ADP
admet-441	138	10	various	various	ADJ
admet-441	138	11	factors	factor	NOUN
admet-441	138	12	,	,	PUNCT
admet-441	138	13	including	include	VERB
admet-441	138	14	gender	gender	NOUN
admet-441	138	15	,	,	PUNCT
admet-441	138	16	age	age	NOUN
admet-441	138	17	,	,	PUNCT
admet-441	138	18	race	race	NOUN
admet-441	138	19	/	/	SYM
admet-441	138	20	ethnicity	ethnicity	NOUN
admet-441	138	21	,	,	PUNCT
admet-441	138	22	genetics	genetic	NOUN
admet-441	138	23	(	(	PUNCT
admet-441	138	24	polymorphisms	polymorphism	NOUN
admet-441	138	25	)	)	PUNCT
admet-441	138	26	,	,	PUNCT
admet-441	138	27	disease	disease	NOUN
admet-441	138	28	state	state	NOUN
admet-441	138	29	,	,	PUNCT
admet-441	138	30	diet	diet	NOUN
admet-441	138	31	,	,	PUNCT
admet-441	138	32	and	and	CCONJ
admet-441	138	33	lifestyle	lifestyle	NOUN
admet-441	138	34	.	.	PUNCT
admet-441	139	1	the	the	DET
admet-441	139	2	impact	impact	NOUN
admet-441	139	3	of	of	ADP
admet-441	139	4	polymorphisms	polymorphism	NOUN
admet-441	139	5	in	in	ADP
admet-441	139	6	drug	drug	NOUN
admet-441	139	7	metabolizing	metabolize	VERB
admet-441	139	8	enzymes	enzyme	NOUN
admet-441	139	9	on	on	ADP
admet-441	139	10	pharmacokinetic	pharmacokinetic	ADJ
admet-441	139	11	variation	variation	NOUN
admet-441	139	12	is	be	AUX
admet-441	139	13	largely	largely	ADV
admet-441	139	14	studied	study	VERB
admet-441	139	15	and	and	CCONJ
admet-441	139	16	known	know	VERB
admet-441	139	17	;	;	PUNCT
admet-441	139	18	however	however	ADV
admet-441	139	19	,	,	PUNCT
admet-441	139	20	knowledge	knowledge	NOUN
admet-441	139	21	regarding	regard	VERB
admet-441	139	22	the	the	DET
admet-441	139	23	impact	impact	NOUN
admet-441	139	24	of	of	ADP
admet-441	139	25	polymorphisms	polymorphism	NOUN
admet-441	139	26	in	in	ADP
admet-441	139	27	drug	drug	NOUN
admet-441	139	28	transporters	transporter	NOUN
admet-441	139	29	is	be	AUX
admet-441	139	30	limited	limited	ADJ
admet-441	139	31	.	.	PUNCT
admet-441	140	1	studies	study	NOUN
admet-441	140	2	undertaken	undertake	VERB
admet-441	140	3	to	to	ADP
admet-441	140	4	date	date	NOUN
admet-441	140	5	report	report	VERB
admet-441	140	6	significant	significant	ADJ
admet-441	140	7	changes	change	NOUN
admet-441	140	8	in	in	ADP
admet-441	140	9	intracellular	intracellular	ADJ
admet-441	140	10	drug	drug	NOUN
admet-441	140	11	levels	level	NOUN
admet-441	140	12	due	due	ADP
admet-441	140	13	to	to	ADP
admet-441	140	14	polymorphisms	polymorphism	NOUN
admet-441	140	15	in	in	ADP
admet-441	140	16	drug	drug	NOUN
admet-441	140	17	transporters	transporter	NOUN
admet-441	140	18	,	,	PUNCT
admet-441	140	19	which	which	PRON
admet-441	140	20	suggests	suggest	VERB
admet-441	140	21	potential	potential	ADJ
admet-441	140	22	alterations	alteration	NOUN
admet-441	140	23	in	in	ADP
admet-441	140	24	the	the	DET
admet-441	140	25	systemic	systemic	ADJ
admet-441	140	26	pharmacokinetics	pharmacokinetic	NOUN
admet-441	140	27	of	of	ADP
admet-441	140	28	drugs	drug	NOUN
admet-441	140	29	.	.	PUNCT
admet-441	141	1	most	most	ADJ
admet-441	141	2	drug	drug	NOUN
admet-441	141	3	transporters	transporter	NOUN
admet-441	141	4	(	(	PUNCT
admet-441	141	5	e.g.	e.g.	ADV
admet-441	141	6	,	,	PUNCT
admet-441	141	7	p	p	NOUN
admet-441	141	8	-	-	PUNCT
admet-441	141	9	gp	gp	NOUN
admet-441	141	10	and	and	CCONJ
admet-441	141	11	mrp-1	mrp-1	PRON
admet-441	141	12	)	)	PUNCT
admet-441	141	13	follow	follow	VERB
admet-441	141	14	a	a	DET
admet-441	141	15	developmental	developmental	ADJ
admet-441	141	16	ontogeny	ontogeny	NOUN
admet-441	141	17	and	and	CCONJ
admet-441	141	18	like	like	ADP
admet-441	141	19	most	most	ADJ
admet-441	141	20	drug	drug	NOUN
admet-441	141	21	metabolizing	metabolize	VERB
admet-441	141	22	enzymes	enzyme	NOUN
admet-441	141	23	,	,	PUNCT
admet-441	141	24	the	the	DET
admet-441	141	25	activities	activity	NOUN
admet-441	141	26	of	of	ADP
admet-441	141	27	membrane	membrane	NOUN
admet-441	141	28	transporters	transporter	NOUN
admet-441	141	29	are	be	AUX
admet-441	141	30	immature	immature	ADJ
admet-441	141	31	in	in	ADP
admet-441	141	32	neonates	neonate	NOUN
admet-441	141	33	.	.	PUNCT
admet-441	142	1	thus	thus	ADV
admet-441	142	2	,	,	PUNCT
admet-441	142	3	future	future	ADJ
admet-441	142	4	research	research	NOUN
admet-441	142	5	is	be	AUX
admet-441	142	6	needed	need	VERB
admet-441	142	7	to	to	PART
admet-441	142	8	drive	drive	VERB
admet-441	142	9	system	system	NOUN
admet-441	142	10	-	-	PUNCT
admet-441	142	11	dependent	dependent	ADJ
admet-441	142	12	scaling	scaling	NOUN
admet-441	142	13	factors	factor	NOUN
admet-441	142	14	for	for	ADP
admet-441	142	15	predicting	predict	VERB
admet-441	142	16	transporter	transporter	NOUN
admet-441	142	17	contributions	contribution	NOUN
admet-441	142	18	of	of	ADP
admet-441	142	19	new	new	ADJ
admet-441	142	20	molecular	molecular	ADJ
admet-441	142	21	entities	entity	NOUN
admet-441	142	22	,	,	PUNCT
admet-441	142	23	in	in	ADP
admet-441	142	24	different	different	ADJ
admet-441	142	25	disease	disease	NOUN
admet-441	142	26	states	state	NOUN
admet-441	142	27	and	and	CCONJ
admet-441	142	28	among	among	ADP
admet-441	142	29	special	special	ADJ
admet-441	142	30	populations	population	NOUN
admet-441	142	31	,	,	PUNCT
admet-441	142	32	using	use	VERB
admet-441	142	33	ivive	ivive	ADJ
admet-441	142	34	-	-	PUNCT
admet-441	142	35	pbpk	pbpk	ADJ
admet-441	142	36	modeling	modeling	NOUN
admet-441	142	37	approaches	approach	NOUN
admet-441	142	38	.	.	PUNCT
admet-441	143	1	conflict	conflict	NOUN
admet-441	143	2	of	of	ADP
admet-441	143	3	interest	interest	NOUN
admet-441	143	4	:	:	PUNCT
admet-441	143	5	none	none	NOUN
admet-441	143	6	references	reference	VERB
admet-441	143	7	[	[	X
admet-441	143	8	1	1	NUM
admet-441	143	9	]	]	X
admet-441	143	10	r.p	r.p	PROPN
admet-441	143	11	.	.	PROPN
admet-441	143	12	oude	oude	PROPN
admet-441	143	13	elferink	elferink	PROPN
admet-441	143	14	,	,	PUNCT
admet-441	143	15	d.k	d.k	PROPN
admet-441	143	16	.	.	PROPN
admet-441	143	17	meijer	meijer	PROPN
admet-441	143	18	,	,	PUNCT
admet-441	143	19	f.	f.	PROPN
admet-441	143	20	kuipers	kuipers	PROPN
admet-441	143	21	,	,	PUNCT
admet-441	144	1	p.l	p.l	PROPN
admet-441	144	2	.	.	PROPN
admet-441	144	3	jansen	jansen	PROPN
admet-441	144	4	,	,	PUNCT
admet-441	144	5	a.k	a.k	PROPN
admet-441	144	6	.	.	PROPN
admet-441	144	7	groen	groen	PROPN
admet-441	144	8	,	,	PUNCT
admet-441	144	9	g.m	g.m	PROPN
admet-441	144	10	.	.	PROPN
admet-441	144	11	groothuis	groothuis	PROPN
admet-441	144	12	.	.	PUNCT
admet-441	145	1	hepatobiliary	hepatobiliary	ADJ
admet-441	145	2	secretion	secretion	NOUN
admet-441	145	3	of	of	ADP
admet-441	145	4	organic	organic	ADJ
admet-441	145	5	compounds	compound	NOUN
admet-441	145	6	;	;	PUNCT
admet-441	145	7	molecular	molecular	ADJ
admet-441	145	8	mechanisms	mechanism	NOUN
admet-441	145	9	of	of	ADP
admet-441	145	10	membrane	membrane	NOUN
admet-441	145	11	transport	transport	NOUN
admet-441	145	12	.	.	PUNCT
admet-441	146	1	biochim	biochim	PROPN
admet-441	146	2	biophys	biophy	NOUN
admet-441	146	3	acta	acta	PROPN
admet-441	146	4	1241	1241	NUM
admet-441	146	5	(	(	PUNCT
admet-441	146	6	1995	1995	NUM
admet-441	146	7	)	)	PUNCT
admet-441	146	8	215	215	NUM
admet-441	146	9	-	-	SYM
admet-441	146	10	268	268	NUM
admet-441	146	11	.	.	PUNCT
admet-441	147	1	[	[	X
admet-441	147	2	2	2	X
admet-441	147	3	]	]	PUNCT
admet-441	147	4	l.	l.	PROPN
admet-441	147	5	zhang	zhang	PROPN
admet-441	147	6	,	,	PUNCT
admet-441	147	7	c.m	c.m	PROPN
admet-441	147	8	.	.	PROPN
admet-441	147	9	brett	brett	PROPN
admet-441	147	10	,	,	PUNCT
admet-441	147	11	k.m	k.m	PROPN
admet-441	147	12	.	.	PROPN
admet-441	147	13	giacomini	giacomini	PROPN
admet-441	147	14	.	.	PUNCT
admet-441	148	1	role	role	NOUN
admet-441	148	2	of	of	ADP
admet-441	148	3	organic	organic	ADJ
admet-441	148	4	cation	cation	NOUN
admet-441	148	5	transporters	transporter	NOUN
admet-441	148	6	in	in	ADP
admet-441	148	7	drug	drug	NOUN
admet-441	148	8	absorption	absorption	NOUN
admet-441	148	9	and	and	CCONJ
admet-441	148	10	elimination	elimination	NOUN
admet-441	148	11	.	.	PUNCT
admet-441	149	1	annu	annu	PROPN
admet-441	149	2	rev	rev	VERB
admet-441	149	3	pharmacol	pharmacol	PROPN
admet-441	149	4	toxicol	toxicol	PROPN
admet-441	149	5	38	38	NUM
admet-441	149	6	(	(	PUNCT
admet-441	149	7	1998	1998	NUM
admet-441	149	8	)	)	PUNCT
admet-441	149	9	431	431	NUM
admet-441	149	10	-	-	SYM
admet-441	149	11	460	460	NUM
admet-441	149	12	.	.	PUNCT
admet-441	150	1	[	[	X
admet-441	150	2	3	3	X
admet-441	150	3	]	]	X
admet-441	150	4	h.	h.	PROPN
admet-441	150	5	kusuhara	kusuhara	PROPN
admet-441	150	6	,	,	PUNCT
admet-441	150	7	y.	y.	PROPN
admet-441	150	8	sugiyama	sugiyama	PROPN
admet-441	150	9	.	.	PUNCT
admet-441	151	1	role	role	NOUN
admet-441	151	2	of	of	ADP
admet-441	151	3	transporters	transporter	NOUN
admet-441	151	4	in	in	ADP
admet-441	151	5	the	the	DET
admet-441	151	6	tissue	tissue	NOUN
admet-441	151	7	-	-	PUNCT
admet-441	151	8	selective	selective	ADJ
admet-441	151	9	distribution	distribution	NOUN
admet-441	151	10	and	and	CCONJ
admet-441	151	11	elimination	elimination	NOUN
admet-441	151	12	of	of	ADP
admet-441	151	13	drugs	drug	NOUN
admet-441	151	14	:	:	PUNCT
admet-441	151	15	transporters	transporter	NOUN
admet-441	151	16	in	in	ADP
admet-441	151	17	the	the	DET
admet-441	151	18	liver	liver	NOUN
admet-441	151	19	,	,	PUNCT
admet-441	151	20	small	small	ADJ
admet-441	151	21	intestine	intestine	NOUN
admet-441	151	22	,	,	PUNCT
admet-441	151	23	brain	brain	NOUN
admet-441	151	24	and	and	CCONJ
admet-441	151	25	kidney	kidney	NOUN
admet-441	151	26	.	.	PUNCT
admet-441	152	1	j	j	PROPN
admet-441	152	2	control	control	NOUN
admet-441	152	3	release	release	VERB
admet-441	152	4	78	78	NUM
admet-441	152	5	(	(	PUNCT
admet-441	152	6	2002	2002	NUM
admet-441	152	7	)	)	PUNCT
admet-441	152	8	43	43	NUM
admet-441	152	9	-	-	SYM
admet-441	152	10	54	54	NUM
admet-441	152	11	.	.	PUNCT
admet-441	153	1	[	[	X
admet-441	153	2	4	4	NUM
admet-441	153	3	]	]	PUNCT
admet-441	153	4	m.	m.	NOUN
admet-441	153	5	muller	muller	PROPN
admet-441	153	6	,	,	PUNCT
admet-441	153	7	p.l	p.l	PROPN
admet-441	153	8	.	.	PROPN
admet-441	153	9	jansen	jansen	PROPN
admet-441	153	10	.	.	PUNCT
admet-441	154	1	molecular	molecular	ADJ
admet-441	154	2	aspects	aspect	NOUN
admet-441	154	3	of	of	ADP
admet-441	154	4	hepatobiliary	hepatobiliary	ADJ
admet-441	154	5	transport	transport	NOUN
admet-441	154	6	.	.	PUNCT
admet-441	155	1	am	be	AUX
admet-441	155	2	j	j	PROPN
admet-441	155	3	physiol	physiol	PROPN
admet-441	155	4	272	272	NUM
admet-441	155	5	(	(	PUNCT
admet-441	155	6	1997	1997	NUM
admet-441	155	7	)	)	PUNCT
admet-441	155	8	g1285	g1285	NOUN
admet-441	155	9	-	-	PUNCT
admet-441	155	10	1303	1303	NUM
admet-441	155	11	.	.	PUNCT
admet-441	156	1	[	[	X
admet-441	156	2	5	5	X
admet-441	156	3	]	]	PUNCT
admet-441	156	4	h.	h.	PROPN
admet-441	156	5	koepsell	koepsell	PROPN
admet-441	156	6	.	.	PUNCT
admet-441	157	1	organic	organic	ADJ
admet-441	157	2	cation	cation	NOUN
admet-441	157	3	transporters	transporter	NOUN
admet-441	157	4	in	in	ADP
admet-441	157	5	intestine	intestine	NOUN
admet-441	157	6	,	,	PUNCT
admet-441	157	7	kidney	kidney	NOUN
admet-441	157	8	,	,	PUNCT
admet-441	157	9	liver	liver	NOUN
admet-441	157	10	,	,	PUNCT
admet-441	157	11	and	and	CCONJ
admet-441	157	12	brain	brain	NOUN
admet-441	157	13	.	.	PUNCT
admet-441	158	1	annu	annu	PROPN
admet-441	158	2	rev	rev	PROPN
admet-441	158	3	physiol	physiol	PROPN
admet-441	158	4	60	60	NUM
admet-441	158	5	(	(	PUNCT
admet-441	158	6	1998	1998	NUM
admet-441	158	7	)	)	PUNCT
admet-441	158	8	243	243	NUM
admet-441	158	9	-	-	SYM
admet-441	158	10	266	266	NUM
admet-441	158	11	.	.	PUNCT
admet-441	159	1	[	[	X
admet-441	159	2	6	6	NUM
admet-441	159	3	]	]	X
admet-441	159	4	d.k	d.k	PROPN
admet-441	159	5	.	.	PROPN
admet-441	159	6	meijer	meijer	PROPN
admet-441	159	7	,	,	PUNCT
admet-441	159	8	g.j	g.j	PROPN
admet-441	159	9	.	.	PROPN
admet-441	159	10	hooiveld	hooiveld	PROPN
admet-441	159	11	,	,	PUNCT
admet-441	159	12	a.h	a.h	PROPN
admet-441	159	13	.	.	PROPN
admet-441	159	14	schinkel	schinkel	PROPN
admet-441	159	15	,	,	PUNCT
admet-441	159	16	j.e	j.e	PROPN
admet-441	159	17	.	.	PROPN
admet-441	159	18	van	van	PROPN
admet-441	159	19	montfoort	montfoort	PROPN
admet-441	159	20	,	,	PUNCT
admet-441	159	21	m.	m.	NOUN
admet-441	159	22	haas	haas	PROPN
admet-441	159	23	,	,	PUNCT
admet-441	159	24	d.	d.	PROPN
admet-441	159	25	de	de	PROPN
admet-441	159	26	zeeuw	zeeuw	PROPN
admet-441	159	27	,	,	PUNCT
admet-441	159	28	f.	f.	PROPN
admet-441	159	29	moolenaar	moolenaar	PROPN
admet-441	159	30	,	,	PUNCT
admet-441	159	31	j.w	j.w	PROPN
admet-441	159	32	.	.	PROPN
admet-441	159	33	smit	smit	PROPN
admet-441	159	34	,	,	PUNCT
admet-441	159	35	p.j	p.j	PROPN
admet-441	159	36	.	.	PROPN
admet-441	159	37	meier	meier	PROPN
admet-441	159	38	.	.	PUNCT
admet-441	160	1	transport	transport	NOUN
admet-441	160	2	mechanisms	mechanism	NOUN
admet-441	160	3	for	for	ADP
admet-441	160	4	cationic	cationic	ADJ
admet-441	160	5	drugs	drug	NOUN
admet-441	160	6	and	and	CCONJ
admet-441	160	7	proteins	protein	NOUN
admet-441	160	8	in	in	ADP
admet-441	160	9	kidney	kidney	NOUN
admet-441	160	10	,	,	PUNCT
admet-441	160	11	liver	liver	NOUN
admet-441	160	12	and	and	CCONJ
admet-441	160	13	intestine	intestine	NOUN
admet-441	160	14	:	:	PUNCT
admet-441	160	15	implication	implication	NOUN
admet-441	160	16	for	for	ADP
admet-441	160	17	drug	drug	NOUN
admet-441	160	18	interactions	interaction	NOUN
admet-441	160	19	and	and	CCONJ
admet-441	160	20	cell	cell	NOUN
admet-441	160	21	-	-	PUNCT
admet-441	160	22	specific	specific	ADJ
admet-441	160	23	drug	drug	NOUN
admet-441	160	24	delivery	delivery	NOUN
admet-441	160	25	.	.	PUNCT
admet-441	161	1	nephrol	nephrol	PROPN
admet-441	161	2	dial	dial	NOUN
admet-441	161	3	transplant	transplant	NOUN
admet-441	161	4	14	14	NUM
admet-441	161	5	suppl	suppl	ADJ
admet-441	161	6	4	4	NUM
admet-441	161	7	(	(	PUNCT
admet-441	161	8	1999	1999	NUM
admet-441	161	9	)	)	PUNCT
admet-441	161	10	1	1	NUM
admet-441	161	11	-	-	SYM
admet-441	161	12	3	3	NUM
admet-441	161	13	.	.	PUNCT
admet-441	162	1	[	[	X
admet-441	162	2	7	7	X
admet-441	162	3	]	]	X
admet-441	162	4	h.	h.	PROPN
admet-441	162	5	suzuki	suzuki	PROPN
admet-441	162	6	,	,	PUNCT
admet-441	162	7	y.	y.	PROPN
admet-441	162	8	sugiyama	sugiyama	PROPN
admet-441	162	9	.	.	PUNCT
admet-441	163	1	transporters	transporter	NOUN
admet-441	163	2	for	for	ADP
admet-441	163	3	bile	bile	NOUN
admet-441	163	4	acids	acid	NOUN
admet-441	163	5	and	and	CCONJ
admet-441	163	6	organic	organic	ADJ
admet-441	163	7	anions	anion	NOUN
admet-441	163	8	.	.	PUNCT
admet-441	164	1	pharm	pharm	NOUN
admet-441	164	2	biotechnol	biotechnol	NOUN
admet-441	164	3	12	12	NUM
admet-441	164	4	(	(	PUNCT
admet-441	164	5	1999	1999	NUM
admet-441	164	6	)	)	PUNCT
admet-441	164	7	387	387	NUM
admet-441	164	8	-	-	NUM
admet-441	164	9	439	439	NUM
admet-441	164	10	.	.	PUNCT
admet-441	165	1	[	[	X
admet-441	165	2	8	8	NUM
admet-441	165	3	]	]	X
admet-441	165	4	d.	d.	PROPN
admet-441	165	5	lautier	lautier	PROPN
admet-441	165	6	,	,	PUNCT
admet-441	165	7	y.	y.	PROPN
admet-441	165	8	canitrot	canitrot	PROPN
admet-441	165	9	,	,	PUNCT
admet-441	165	10	r.g	r.g	PROPN
admet-441	165	11	.	.	PROPN
admet-441	165	12	deeley	deeley	PROPN
admet-441	165	13	,	,	PUNCT
admet-441	165	14	s.p	s.p	PROPN
admet-441	165	15	.	.	PROPN
admet-441	165	16	cole	cole	PROPN
admet-441	165	17	.	.	PUNCT
admet-441	166	1	multidrug	multidrug	NOUN
admet-441	166	2	resistance	resistance	NOUN
admet-441	166	3	mediated	mediate	VERB
admet-441	166	4	by	by	ADP
admet-441	166	5	the	the	DET
admet-441	166	6	multidrug	multidrug	NOUN
admet-441	166	7	resistance	resistance	NOUN
admet-441	166	8	protein	protein	NOUN
admet-441	166	9	(	(	PUNCT
admet-441	166	10	mrp	mrp	NOUN
admet-441	166	11	)	)	PUNCT
admet-441	166	12	gene	gene	NOUN
admet-441	166	13	.	.	PUNCT
admet-441	167	1	biochem	biochem	PROPN
admet-441	167	2	pharmacol	pharmacol	VERB
admet-441	167	3	52	52	NUM
admet-441	167	4	(	(	PUNCT
admet-441	167	5	1996	1996	NUM
admet-441	167	6	)	)	PUNCT
admet-441	167	7	967	967	NUM
admet-441	167	8	-	-	SYM
admet-441	167	9	977	977	NUM
admet-441	167	10	.	.	PUNCT
admet-441	168	1	[	[	X
admet-441	168	2	9	9	NUM
admet-441	168	3	]	]	X
admet-441	168	4	g.j	g.j	PROPN
admet-441	168	5	.	.	PROPN
admet-441	168	6	hooiveld	hooiveld	PROPN
admet-441	168	7	,	,	PUNCT
admet-441	168	8	j.e	j.e	PROPN
admet-441	168	9	.	.	PROPN
admet-441	168	10	van	van	PROPN
admet-441	168	11	montfoort	montfoort	PROPN
admet-441	168	12	,	,	PUNCT
admet-441	168	13	d.k	d.k	PROPN
admet-441	168	14	.	.	PROPN
admet-441	168	15	meijer	meijer	PROPN
admet-441	168	16	,	,	PUNCT
admet-441	168	17	m.	m.	NOUN
admet-441	168	18	muller	muller	PROPN
admet-441	168	19	.	.	PUNCT
admet-441	169	1	function	function	NOUN
admet-441	169	2	and	and	CCONJ
admet-441	169	3	regulation	regulation	NOUN
admet-441	169	4	of	of	ADP
admet-441	169	5	atp	atp	NOUN
admet-441	169	6	-	-	PUNCT
admet-441	169	7	binding	bind	VERB
admet-441	169	8	cassette	cassette	NOUN
admet-441	169	9	transport	transport	NOUN
admet-441	169	10	proteins	protein	NOUN
admet-441	169	11	involved	involve	VERB
admet-441	169	12	in	in	ADP
admet-441	169	13	hepatobiliary	hepatobiliary	ADJ
admet-441	169	14	transport	transport	NOUN
admet-441	169	15	.	.	PUNCT
admet-441	170	1	eur	eur	PROPN
admet-441	170	2	j	j	PROPN
admet-441	170	3	pharm	pharm	PROPN
admet-441	170	4	sci	sci	PROPN
admet-441	170	5	12	12	NUM
admet-441	170	6	(	(	PUNCT
admet-441	170	7	2001	2001	NUM
admet-441	170	8	)	)	PUNCT
admet-441	170	9	525	525	NUM
admet-441	170	10	-	-	SYM
admet-441	170	11	543	543	NUM
admet-441	170	12	.	.	PUNCT
admet-441	171	1	[	[	X
admet-441	171	2	10	10	NUM
admet-441	171	3	]	]	X
admet-441	171	4	g.	g.	PROPN
admet-441	171	5	lee	lee	PROPN
admet-441	171	6	,	,	PUNCT
admet-441	171	7	s.	s.	PROPN
admet-441	171	8	dallas	dallas	PROPN
admet-441	171	9	,	,	PUNCT
admet-441	171	10	m.	m.	PROPN
admet-441	171	11	hong	hong	PROPN
admet-441	171	12	,	,	PUNCT
admet-441	171	13	r.	r.	PROPN
admet-441	171	14	bendayan	bendayan	PROPN
admet-441	171	15	.	.	PUNCT
admet-441	172	1	drug	drug	NOUN
admet-441	172	2	transporters	transporter	NOUN
admet-441	172	3	in	in	ADP
admet-441	172	4	the	the	DET
admet-441	172	5	central	central	ADJ
admet-441	172	6	nervous	nervous	ADJ
admet-441	172	7	system	system	NOUN
admet-441	172	8	:	:	PUNCT
admet-441	172	9	brain	brain	NOUN
admet-441	172	10	barriers	barrier	NOUN
admet-441	172	11	and	and	CCONJ
admet-441	172	12	brain	brain	NOUN
admet-441	172	13	parenchyma	parenchyma	NOUN
admet-441	172	14	considerations	consideration	NOUN
admet-441	172	15	.	.	PUNCT
admet-441	173	1	pharmacol	pharmacol	PROPN
admet-441	173	2	rev	rev	VERB
admet-441	173	3	53	53	NUM
admet-441	173	4	(	(	PUNCT
admet-441	173	5	2001	2001	NUM
admet-441	173	6	)	)	PUNCT
admet-441	173	7	569	569	NUM
admet-441	173	8	-	-	SYM
admet-441	173	9	596	596	NUM
admet-441	173	10	.	.	PUNCT
admet-441	174	1	[	[	X
admet-441	174	2	11	11	NUM
admet-441	174	3	]	]	X
admet-441	174	4	n.	n.	PROPN
admet-441	174	5	mizuno	mizuno	PROPN
admet-441	174	6	,	,	PUNCT
admet-441	174	7	t.	t.	PROPN
admet-441	174	8	niwa	niwa	PROPN
admet-441	174	9	,	,	PUNCT
admet-441	174	10	y.	y.	PROPN
admet-441	174	11	yotsumoto	yotsumoto	PROPN
admet-441	174	12	,	,	PUNCT
admet-441	174	13	y.	y.	PROPN
admet-441	174	14	sugiyama	sugiyama	PROPN
admet-441	174	15	.	.	PUNCT
admet-441	175	1	impact	impact	NOUN
admet-441	175	2	of	of	ADP
admet-441	175	3	drug	drug	NOUN
admet-441	175	4	transporter	transporter	NOUN
admet-441	175	5	studies	study	NOUN
admet-441	175	6	on	on	ADP
admet-441	175	7	drug	drug	NOUN
admet-441	175	8	discovery	discovery	NOUN
admet-441	175	9	and	and	CCONJ
admet-441	175	10	development	development	NOUN
admet-441	175	11	.	.	PUNCT
admet-441	176	1	pharmacol	pharmacol	PROPN
admet-441	176	2	rev	rev	VERB
admet-441	176	3	55	55	NUM
admet-441	176	4	(	(	PUNCT
admet-441	176	5	2003	2003	NUM
admet-441	176	6	)	)	PUNCT
admet-441	176	7	425	425	NUM
admet-441	176	8	-	-	SYM
admet-441	176	9	461	461	NUM
admet-441	176	10	.	.	PUNCT
admet-441	177	1	[	[	X
admet-441	177	2	12	12	NUM
admet-441	177	3	]	]	X
admet-441	177	4	m.v	m.v	PROPN
admet-441	177	5	.	.	PROPN
admet-441	177	6	varma	varma	PROPN
admet-441	177	7	,	,	PUNCT
admet-441	177	8	c.m	c.m	PROPN
admet-441	177	9	.	.	PROPN
admet-441	177	10	ambler	ambler	PROPN
admet-441	177	11	,	,	PUNCT
admet-441	177	12	m.	m.	PROPN
admet-441	177	13	ullah	ullah	PROPN
admet-441	177	14	,	,	PUNCT
admet-441	177	15	c.j	c.j	PROPN
admet-441	177	16	.	.	PROPN
admet-441	177	17	rotter	rotter	PROPN
admet-441	177	18	,	,	PUNCT
admet-441	177	19	h.	h.	PROPN
admet-441	177	20	sun	sun	PROPN
admet-441	177	21	,	,	PUNCT
admet-441	177	22	j.	j.	PROPN
admet-441	177	23	litchfield	litchfield	PROPN
admet-441	177	24	,	,	PUNCT
admet-441	177	25	k.s	k.s	PROPN
admet-441	177	26	.	.	PROPN
admet-441	177	27	fenner	fenner	PROPN
admet-441	177	28	,	,	PUNCT
admet-441	177	29	a.f	a.f	PROPN
admet-441	177	30	.	.	PROPN
admet-441	177	31	el	el	PROPN
admet-441	177	32	-	-	PROPN
admet-441	177	33	kattan	kattan	PROPN
admet-441	177	34	.	.	PUNCT
admet-441	178	1	targeting	target	VERB
admet-441	178	2	intestinal	intestinal	ADJ
admet-441	178	3	transporters	transporter	NOUN
admet-441	178	4	for	for	ADP
admet-441	178	5	optimizing	optimize	VERB
admet-441	178	6	oral	oral	ADJ
admet-441	178	7	drug	drug	NOUN
admet-441	178	8	absorption	absorption	NOUN
admet-441	178	9	.	.	PUNCT
admet-441	179	1	curr	curr	PROPN
admet-441	179	2	drug	drug	PROPN
admet-441	179	3	metab	metab	PROPN
admet-441	179	4	11	11	NUM
admet-441	179	5	(	(	PUNCT
admet-441	179	6	2010	2010	NUM
admet-441	179	7	)	)	PUNCT
admet-441	179	8	730	730	NUM
admet-441	179	9	-	-	SYM
admet-441	179	10	742	742	NUM
admet-441	179	11	.	.	PUNCT
admet-441	180	1	[	[	X
admet-441	180	2	13	13	NUM
admet-441	180	3	]	]	SYM
admet-441	180	4	j.d	j.d	PROPN
admet-441	180	5	.	.	PROPN
admet-441	180	6	schuetz	schuetz	PROPN
admet-441	180	7	,	,	PUNCT
admet-441	180	8	p.w	p.w	PROPN
admet-441	180	9	.	.	PROPN
admet-441	180	10	swaan	swaan	PROPN
admet-441	180	11	,	,	PUNCT
admet-441	180	12	d.j	d.j	PROPN
admet-441	180	13	.	.	PROPN
admet-441	180	14	tweedie	tweedie	PROPN
admet-441	180	15	.	.	PUNCT
admet-441	181	1	the	the	DET
admet-441	181	2	role	role	NOUN
admet-441	181	3	of	of	ADP
admet-441	181	4	transporters	transporter	NOUN
admet-441	181	5	in	in	ADP
admet-441	181	6	toxicity	toxicity	NOUN
admet-441	181	7	and	and	CCONJ
admet-441	181	8	disease	disease	NOUN
admet-441	181	9	.	.	PUNCT
admet-441	182	1	drug	drug	NOUN
admet-441	182	2	metab	metab	PROPN
admet-441	182	3	dispos	dispos	PROPN
admet-441	182	4	42	42	NUM
admet-441	182	5	(	(	PUNCT
admet-441	182	6	2014	2014	NUM
admet-441	182	7	)	)	PUNCT
admet-441	182	8	541	541	NUM
admet-441	182	9	-	-	SYM
admet-441	182	10	545	545	NUM
admet-441	182	11	.	.	PUNCT
admet-441	183	1	pankajini	pankajini	PROPN
admet-441	183	2	mallick	mallick	PROPN
admet-441	183	3	admet	admet	PROPN
admet-441	183	4	&	&	CCONJ
admet-441	183	5	dmpk	dmpk	PROPN
admet-441	183	6	5(4	5(4	NOUN
admet-441	183	7	)	)	PUNCT
admet-441	183	8	(	(	PUNCT
admet-441	183	9	2017	2017	NUM
admet-441	183	10	)	)	PUNCT
admet-441	183	11	201	201	NUM
admet-441	183	12	-	-	SYM
admet-441	183	13	211	211	NUM
admet-441	183	14	208	208	NUM
admet-441	183	15	[	[	X
admet-441	183	16	14	14	NUM
admet-441	183	17	]	]	X
admet-441	183	18	t.d	t.d	PROPN
admet-441	183	19	.	.	PROPN
admet-441	183	20	bjornsson	bjornsson	PROPN
admet-441	183	21	,	,	PUNCT
admet-441	183	22	j.t	j.t	PROPN
admet-441	183	23	.	.	PROPN
admet-441	183	24	callaghan	callaghan	PROPN
admet-441	183	25	,	,	PUNCT
admet-441	183	26	h.j	h.j	PROPN
admet-441	183	27	.	.	PROPN
admet-441	183	28	einolf	einolf	PROPN
admet-441	183	29	,	,	PUNCT
admet-441	183	30	v.	v.	PROPN
admet-441	183	31	fischer	fischer	PROPN
admet-441	183	32	,	,	PUNCT
admet-441	183	33	l.	l.	PROPN
admet-441	183	34	gan	gan	PROPN
admet-441	183	35	,	,	PUNCT
admet-441	183	36	s.	s.	PROPN
admet-441	183	37	grimm	grimm	PROPN
admet-441	183	38	,	,	PUNCT
admet-441	183	39	j.	j.	PROPN
admet-441	183	40	kao	kao	PROPN
admet-441	183	41	,	,	PUNCT
admet-441	183	42	s.p	s.p	PROPN
admet-441	183	43	.	.	PROPN
admet-441	183	44	king	king	PROPN
admet-441	183	45	,	,	PUNCT
admet-441	183	46	g.	g.	PROPN
admet-441	183	47	miwa	miwa	PROPN
admet-441	183	48	,	,	PUNCT
admet-441	183	49	l.	l.	PROPN
admet-441	183	50	ni	ni	PROPN
admet-441	183	51	,	,	PUNCT
admet-441	183	52	g.	g.	PROPN
admet-441	183	53	kumar	kumar	PROPN
admet-441	183	54	,	,	PUNCT
admet-441	183	55	j.	j.	PROPN
admet-441	183	56	mcleod	mcleod	PROPN
admet-441	183	57	,	,	PUNCT
admet-441	183	58	r.s	r.s	PROPN
admet-441	183	59	.	.	PROPN
admet-441	183	60	obach	obach	PROPN
admet-441	183	61	,	,	PUNCT
admet-441	183	62	s.	s.	PROPN
admet-441	183	63	roberts	roberts	PROPN
admet-441	183	64	,	,	PUNCT
admet-441	183	65	a.	a.	PROPN
admet-441	183	66	roe	roe	PROPN
admet-441	183	67	,	,	PUNCT
admet-441	183	68	a.	a.	NOUN
admet-441	183	69	shah	shah	PROPN
admet-441	183	70	,	,	PUNCT
admet-441	183	71	f.	f.	PROPN
admet-441	183	72	snikeris	snikeris	PROPN
admet-441	183	73	,	,	PUNCT
admet-441	183	74	j.t	j.t	PROPN
admet-441	183	75	.	.	PROPN
admet-441	183	76	sullivan	sullivan	PROPN
admet-441	183	77	,	,	PUNCT
admet-441	183	78	d.	d.	PROPN
admet-441	183	79	tweedie	tweedie	PROPN
admet-441	183	80	,	,	PUNCT
admet-441	183	81	j.m	j.m	PROPN
admet-441	183	82	.	.	PROPN
admet-441	183	83	vega	vega	PROPN
admet-441	183	84	,	,	PUNCT
admet-441	183	85	j.	j.	PROPN
admet-441	183	86	walsh	walsh	PROPN
admet-441	183	87	,	,	PUNCT
admet-441	183	88	s.a	s.a	PROPN
admet-441	183	89	.	.	PROPN
admet-441	183	90	wrighton	wrighton	PROPN
admet-441	183	91	,	,	PUNCT
admet-441	183	92	r.	r.	PROPN
admet-441	183	93	pharmaceutical	pharmaceutical	PROPN
admet-441	183	94	,	,	PUNCT
admet-441	183	95	g.	g.	PROPN
admet-441	183	96	manufacturers	manufacturer	NOUN
admet-441	183	97	of	of	ADP
admet-441	183	98	america	america	PROPN
admet-441	183	99	drug	drug	PROPN
admet-441	183	100	metabolism	metabolism	NOUN
admet-441	183	101	/	/	SYM
admet-441	183	102	clinical	clinical	ADJ
admet-441	183	103	pharmacology	pharmacology	NOUN
admet-441	183	104	technical	technical	ADJ
admet-441	183	105	working	working	NOUN
admet-441	183	106	,	,	PUNCT
admet-441	183	107	f.d.a.c.f.d	f.d.a.c.f.d	NOUN
admet-441	183	108	.	.	PUNCT
admet-441	183	109	evaluation	evaluation	NOUN
admet-441	183	110	,	,	PUNCT
admet-441	183	111	research	research	NOUN
admet-441	183	112	.	.	PUNCT
admet-441	184	1	the	the	DET
admet-441	184	2	conduct	conduct	NOUN
admet-441	184	3	of	of	ADP
admet-441	184	4	in	in	ADP
admet-441	184	5	vitro	vitro	X
admet-441	184	6	and	and	CCONJ
admet-441	184	7	in	in	ADP
admet-441	184	8	vivo	vivo	ADJ
admet-441	184	9	drug	drug	NOUN
admet-441	184	10	-	-	PUNCT
admet-441	184	11	drug	drug	NOUN
admet-441	184	12	interaction	interaction	NOUN
admet-441	184	13	studies	study	NOUN
admet-441	184	14	:	:	PUNCT
admet-441	184	15	a	a	DET
admet-441	184	16	pharmaceutical	pharmaceutical	ADJ
admet-441	184	17	research	research	NOUN
admet-441	184	18	and	and	CCONJ
admet-441	184	19	manufacturers	manufacturer	NOUN
admet-441	184	20	of	of	ADP
admet-441	184	21	america	america	PROPN
admet-441	184	22	(	(	PUNCT
admet-441	184	23	phrma	phrma	PROPN
admet-441	184	24	)	)	PUNCT
admet-441	184	25	perspective	perspective	NOUN
admet-441	184	26	.	.	PUNCT
admet-441	185	1	drug	drug	NOUN
admet-441	185	2	metab	metab	PROPN
admet-441	185	3	dispos	dispos	PROPN
admet-441	185	4	31	31	NUM
admet-441	185	5	(	(	PUNCT
admet-441	185	6	2003	2003	NUM
admet-441	185	7	)	)	PUNCT
admet-441	185	8	815	815	NUM
admet-441	185	9	-	-	SYM
admet-441	185	10	832	832	NUM
admet-441	185	11	.	.	PUNCT
admet-441	186	1	[	[	X
admet-441	186	2	15	15	NUM
admet-441	186	3	]	]	X
admet-441	186	4	x.	x.	PROPN
admet-441	186	5	qiu	qiu	PROPN
admet-441	186	6	,	,	PUNCT
admet-441	186	7	h.	h.	PROPN
admet-441	186	8	zhang	zhang	PROPN
admet-441	186	9	,	,	PUNCT
admet-441	186	10	y.	y.	PROPN
admet-441	186	11	lai	lai	PROPN
admet-441	186	12	.	.	PUNCT
admet-441	187	1	quantitative	quantitative	ADJ
admet-441	187	2	targeted	target	VERB
admet-441	187	3	proteomics	proteomic	NOUN
admet-441	187	4	for	for	ADP
admet-441	187	5	membrane	membrane	NOUN
admet-441	187	6	transporter	transporter	NOUN
admet-441	187	7	proteins	protein	NOUN
admet-441	187	8	:	:	PUNCT
admet-441	187	9	method	method	NOUN
admet-441	187	10	and	and	CCONJ
admet-441	187	11	application	application	NOUN
admet-441	187	12	.	.	PUNCT
admet-441	188	1	aaps	aaps	PROPN
admet-441	189	1	j	j	PROPN
admet-441	189	2	16	16	NUM
admet-441	189	3	(	(	PUNCT
admet-441	189	4	2014	2014	NUM
admet-441	189	5	)	)	PUNCT
admet-441	189	6	714	714	NUM
admet-441	189	7	-	-	SYM
admet-441	189	8	726	726	NUM
admet-441	189	9	.	.	PUNCT
admet-441	190	1	[	[	X
admet-441	190	2	16	16	NUM
admet-441	190	3	]	]	X
admet-441	190	4	l.g	l.g	PROPN
admet-441	190	5	.	.	PUNCT
admet-441	190	6	zhang	zhang	PROPN
admet-441	190	7	d.	d.	PROPN
admet-441	190	8	,	,	PUNCT
admet-441	190	9	ding	ding	NOUN
admet-441	190	10	x.	x.	NOUN
admet-441	190	11	,	,	PUNCT
admet-441	190	12	lu	lu	PROPN
admet-441	190	13	c.	c.	PROPN
admet-441	190	14	preclinical	preclinical	ADJ
admet-441	190	15	experimental	experimental	ADJ
admet-441	190	16	models	model	NOUN
admet-441	190	17	of	of	ADP
admet-441	190	18	drug	drug	NOUN
admet-441	190	19	metabolism	metabolism	NOUN
admet-441	190	20	and	and	CCONJ
admet-441	190	21	disposition	disposition	NOUN
admet-441	190	22	in	in	ADP
admet-441	190	23	drug	drug	NOUN
admet-441	190	24	discovery	discovery	NOUN
admet-441	190	25	and	and	CCONJ
admet-441	190	26	development	development	NOUN
admet-441	190	27	.	.	PUNCT
admet-441	191	1	acta	acta	PROPN
admet-441	191	2	pharmaceutica	pharmaceutica	PROPN
admet-441	191	3	sinica	sinica	PROPN
admet-441	191	4	b	b	PROPN
admet-441	191	5	,	,	PUNCT
admet-441	191	6	2012	2012	NUM
admet-441	191	7	,	,	PUNCT
admet-441	191	8	pp	pp	ADV
admet-441	191	9	.	.	PUNCT
admet-441	192	1	549–561	549–561	NUM
admet-441	192	2	.	.	PUNCT
admet-441	193	1	[	[	X
admet-441	193	2	17	17	NUM
admet-441	193	3	]	]	PUNCT
admet-441	193	4	k.	k.	PROPN
admet-441	193	5	horie	horie	PROPN
admet-441	193	6	,	,	PUNCT
admet-441	193	7	f.	f.	PROPN
admet-441	193	8	tang	tang	PROPN
admet-441	193	9	,	,	PUNCT
admet-441	193	10	r.t	r.t	PROPN
admet-441	193	11	.	.	PROPN
admet-441	193	12	borchardt	borchardt	ADJ
admet-441	193	13	.	.	PUNCT
admet-441	194	1	isolation	isolation	NOUN
admet-441	194	2	and	and	CCONJ
admet-441	194	3	characterization	characterization	NOUN
admet-441	194	4	of	of	ADP
admet-441	194	5	caco-2	caco-2	NUM
admet-441	194	6	subclones	subclone	NOUN
admet-441	194	7	expressing	express	VERB
admet-441	194	8	high	high	ADJ
admet-441	194	9	levels	level	NOUN
admet-441	194	10	of	of	ADP
admet-441	194	11	multidrug	multidrug	NOUN
admet-441	194	12	resistance	resistance	NOUN
admet-441	194	13	protein	protein	NOUN
admet-441	194	14	efflux	efflux	VERB
admet-441	194	15	transporter	transporter	NOUN
admet-441	194	16	.	.	PUNCT
admet-441	195	1	pharm	pharm	NOUN
admet-441	195	2	res	re	VERB
admet-441	195	3	20	20	NUM
admet-441	195	4	(	(	PUNCT
admet-441	195	5	2003	2003	NUM
admet-441	195	6	)	)	PUNCT
admet-441	195	7	161	161	NUM
admet-441	195	8	-	-	SYM
admet-441	195	9	168	168	NUM
admet-441	195	10	.	.	PUNCT
admet-441	196	1	[	[	X
admet-441	196	2	18	18	NUM
admet-441	196	3	]	]	X
admet-441	196	4	m.d	m.d	PROPN
admet-441	196	5	.	.	PROPN
admet-441	196	6	troutman	troutman	PROPN
admet-441	196	7	,	,	PUNCT
admet-441	196	8	d.r	d.r	PROPN
admet-441	196	9	.	.	PROPN
admet-441	196	10	thakker	thakker	PROPN
admet-441	196	11	.	.	PUNCT
admet-441	197	1	novel	novel	ADJ
admet-441	197	2	experimental	experimental	ADJ
admet-441	197	3	parameters	parameter	NOUN
admet-441	197	4	to	to	PART
admet-441	197	5	quantify	quantify	VERB
admet-441	197	6	the	the	DET
admet-441	197	7	modulation	modulation	NOUN
admet-441	197	8	of	of	ADP
admet-441	197	9	absorptive	absorptive	ADJ
admet-441	197	10	and	and	CCONJ
admet-441	197	11	secretory	secretory	ADJ
admet-441	197	12	transport	transport	NOUN
admet-441	197	13	of	of	ADP
admet-441	197	14	compounds	compound	NOUN
admet-441	197	15	by	by	ADP
admet-441	197	16	p	p	NOUN
admet-441	197	17	-	-	PUNCT
admet-441	197	18	glycoprotein	glycoprotein	NOUN
admet-441	197	19	in	in	ADP
admet-441	197	20	cell	cell	NOUN
admet-441	197	21	culture	culture	NOUN
admet-441	197	22	models	model	NOUN
admet-441	197	23	of	of	ADP
admet-441	197	24	intestinal	intestinal	ADJ
admet-441	197	25	epithelium	epithelium	NOUN
admet-441	197	26	.	.	PUNCT
admet-441	198	1	pharm	pharm	NOUN
admet-441	198	2	res	re	VERB
admet-441	198	3	20	20	NUM
admet-441	198	4	(	(	PUNCT
admet-441	198	5	2003	2003	NUM
admet-441	198	6	)	)	PUNCT
admet-441	198	7	1210	1210	NUM
admet-441	198	8	-	-	SYM
admet-441	198	9	1224	1224	NUM
admet-441	198	10	.	.	PUNCT
admet-441	199	1	[	[	X
admet-441	199	2	19	19	NUM
admet-441	199	3	]	]	PUNCT
admet-441	199	4	a.	a.	NOUN
admet-441	199	5	balakrishnan	balakrishnan	PROPN
admet-441	199	6	,	,	PUNCT
admet-441	199	7	n.	n.	PROPN
admet-441	199	8	hussainzada	hussainzada	PROPN
admet-441	199	9	,	,	PUNCT
admet-441	199	10	p.	p.	PROPN
admet-441	199	11	gonzalez	gonzalez	PROPN
admet-441	199	12	,	,	PUNCT
admet-441	199	13	m.	m.	NOUN
admet-441	199	14	bermejo	bermejo	PROPN
admet-441	199	15	,	,	PUNCT
admet-441	199	16	p.w	p.w	PROPN
admet-441	199	17	.	.	PROPN
admet-441	199	18	swaan	swaan	PROPN
admet-441	199	19	,	,	PUNCT
admet-441	199	20	j.e	j.e	PROPN
admet-441	199	21	.	.	PROPN
admet-441	199	22	polli	polli	PROPN
admet-441	199	23	.	.	PUNCT
admet-441	200	1	bias	bias	PROPN
admet-441	200	2	in	in	ADP
admet-441	200	3	estimation	estimation	NOUN
admet-441	200	4	of	of	ADP
admet-441	200	5	transporter	transporter	NOUN
admet-441	200	6	kinetic	kinetic	ADJ
admet-441	200	7	parameters	parameter	NOUN
admet-441	200	8	from	from	ADP
admet-441	200	9	overexpression	overexpression	NOUN
admet-441	200	10	systems	system	NOUN
admet-441	200	11	:	:	PUNCT
admet-441	200	12	interplay	interplay	NOUN
admet-441	200	13	of	of	ADP
admet-441	200	14	transporter	transporter	NOUN
admet-441	200	15	expression	expression	NOUN
admet-441	200	16	level	level	NOUN
admet-441	200	17	and	and	CCONJ
admet-441	200	18	substrate	substrate	NOUN
admet-441	200	19	affinity	affinity	NOUN
admet-441	200	20	.	.	PUNCT
admet-441	201	1	j	j	PROPN
admet-441	201	2	pharmacol	pharmacol	PROPN
admet-441	201	3	exp	exp	NOUN
admet-441	201	4	ther	ther	NOUN
admet-441	201	5	320	320	NUM
admet-441	201	6	(	(	PUNCT
admet-441	201	7	2007	2007	NUM
admet-441	201	8	)	)	PUNCT
admet-441	201	9	133	133	NUM
admet-441	201	10	-	-	SYM
admet-441	201	11	144	144	NUM
admet-441	201	12	.	.	PUNCT
admet-441	202	1	[	[	X
admet-441	202	2	20	20	NUM
admet-441	202	3	]	]	X
admet-441	202	4	y.	y.	PROPN
admet-441	202	5	shirasaka	shirasaka	PROPN
admet-441	202	6	,	,	PUNCT
admet-441	202	7	t.	t.	PROPN
admet-441	202	8	sakane	sakane	PROPN
admet-441	202	9	,	,	PUNCT
admet-441	202	10	s.	s.	PROPN
admet-441	202	11	yamashita	yamashita	PROPN
admet-441	202	12	.	.	PUNCT
admet-441	203	1	effect	effect	NOUN
admet-441	203	2	of	of	ADP
admet-441	203	3	p	p	NOUN
admet-441	203	4	-	-	PUNCT
admet-441	203	5	glycoprotein	glycoprotein	NOUN
admet-441	203	6	expression	expression	NOUN
admet-441	203	7	levels	level	NOUN
admet-441	203	8	on	on	ADP
admet-441	203	9	the	the	DET
admet-441	203	10	concentration	concentration	NOUN
admet-441	203	11	-	-	PUNCT
admet-441	203	12	dependent	dependent	ADJ
admet-441	203	13	permeability	permeability	NOUN
admet-441	203	14	of	of	ADP
admet-441	203	15	drugs	drug	NOUN
admet-441	203	16	to	to	ADP
admet-441	203	17	the	the	DET
admet-441	203	18	cell	cell	NOUN
admet-441	203	19	membrane	membrane	NOUN
admet-441	203	20	.	.	PUNCT
admet-441	204	1	j	j	PROPN
admet-441	204	2	pharm	pharm	PROPN
admet-441	204	3	sci	sci	PROPN
admet-441	204	4	97	97	NUM
admet-441	204	5	(	(	PUNCT
admet-441	204	6	2008	2008	NUM
admet-441	204	7	)	)	PUNCT
admet-441	204	8	553565	553565	NUM
admet-441	204	9	.	.	PUNCT
admet-441	205	1	[	[	X
admet-441	205	2	21	21	NUM
admet-441	205	3	]	]	X
admet-441	205	4	k.r	k.r	PROPN
admet-441	205	5	.	.	PROPN
admet-441	205	6	korzekwa	korzekwa	PROPN
admet-441	205	7	,	,	PUNCT
admet-441	205	8	s.	s.	PROPN
admet-441	205	9	nagar	nagar	PROPN
admet-441	205	10	,	,	PUNCT
admet-441	205	11	j.	j.	PROPN
admet-441	205	12	tucker	tucker	PROPN
admet-441	205	13	,	,	PUNCT
admet-441	205	14	e.a	e.a	PROPN
admet-441	205	15	.	.	PROPN
admet-441	205	16	weiskircher	weiskircher	PROPN
admet-441	205	17	,	,	PUNCT
admet-441	205	18	s.	s.	PROPN
admet-441	205	19	bhoopathy	bhoopathy	PROPN
admet-441	205	20	,	,	PUNCT
admet-441	205	21	i.j	i.j	PROPN
admet-441	205	22	.	.	PROPN
admet-441	205	23	hidalgo	hidalgo	PROPN
admet-441	205	24	.	.	PUNCT
admet-441	205	25	models	model	NOUN
admet-441	205	26	to	to	PART
admet-441	205	27	predict	predict	VERB
admet-441	205	28	unbound	unbound	NOUN
admet-441	205	29	intracellular	intracellular	ADJ
admet-441	205	30	drug	drug	NOUN
admet-441	205	31	concentrations	concentration	NOUN
admet-441	205	32	in	in	ADP
admet-441	205	33	the	the	DET
admet-441	205	34	presence	presence	NOUN
admet-441	205	35	of	of	ADP
admet-441	205	36	transporters	transporter	NOUN
admet-441	205	37	.	.	PUNCT
admet-441	206	1	drug	drug	NOUN
admet-441	206	2	metab	metab	PROPN
admet-441	206	3	dispos	dispos	PROPN
admet-441	206	4	40	40	NUM
admet-441	206	5	(	(	PUNCT
admet-441	206	6	2012	2012	NUM
admet-441	206	7	)	)	PUNCT
admet-441	206	8	865	865	NUM
admet-441	206	9	-	-	NUM
admet-441	206	10	876	876	NUM
admet-441	206	11	.	.	PUNCT
admet-441	207	1	[	[	X
admet-441	207	2	22	22	NUM
admet-441	207	3	]	]	X
admet-441	207	4	d.a	d.a	PROPN
admet-441	207	5	.	.	PROPN
admet-441	207	6	smith	smith	PROPN
admet-441	207	7	,	,	PUNCT
admet-441	207	8	l.	l.	PROPN
admet-441	207	9	di	di	PROPN
admet-441	207	10	,	,	PUNCT
admet-441	207	11	e.h	e.h	PROPN
admet-441	207	12	.	.	PROPN
admet-441	207	13	kerns	kerns	PROPN
admet-441	207	14	.	.	PUNCT
admet-441	208	1	the	the	DET
admet-441	208	2	effect	effect	NOUN
admet-441	208	3	of	of	ADP
admet-441	208	4	plasma	plasma	NOUN
admet-441	208	5	protein	protein	NOUN
admet-441	208	6	binding	bind	VERB
admet-441	208	7	on	on	ADP
admet-441	208	8	in	in	ADP
admet-441	208	9	vivo	vivo	ADJ
admet-441	208	10	efficacy	efficacy	NOUN
admet-441	208	11	:	:	PUNCT
admet-441	208	12	misconceptions	misconception	NOUN
admet-441	208	13	in	in	ADP
admet-441	208	14	drug	drug	NOUN
admet-441	208	15	discovery	discovery	NOUN
admet-441	208	16	.	.	PUNCT
admet-441	209	1	nat	nat	PROPN
admet-441	209	2	rev	rev	PROPN
admet-441	209	3	drug	drug	PROPN
admet-441	209	4	discov	discov	PROPN
admet-441	209	5	9	9	NUM
admet-441	209	6	(	(	PUNCT
admet-441	209	7	2010	2010	NUM
admet-441	209	8	)	)	PUNCT
admet-441	209	9	929	929	NUM
admet-441	209	10	-	-	SYM
admet-441	209	11	939	939	NUM
admet-441	209	12	.	.	PUNCT
admet-441	210	1	[	[	X
admet-441	210	2	23	23	NUM
admet-441	210	3	]	]	PUNCT
admet-441	210	4	t.	t.	NOUN
admet-441	210	5	yoshikado	yoshikado	PROPN
admet-441	210	6	,	,	PUNCT
admet-441	210	7	k.	k.	PROPN
admet-441	210	8	toshimoto	toshimoto	PROPN
admet-441	210	9	,	,	PUNCT
admet-441	210	10	t.	t.	PROPN
admet-441	210	11	nakada	nakada	PROPN
admet-441	210	12	,	,	PUNCT
admet-441	210	13	k.	k.	PROPN
admet-441	210	14	ikejiri	ikejiri	PROPN
admet-441	210	15	,	,	PUNCT
admet-441	210	16	h.	h.	PROPN
admet-441	210	17	kusuhara	kusuhara	PROPN
admet-441	210	18	,	,	PUNCT
admet-441	210	19	k.	k.	PROPN
admet-441	210	20	maeda	maeda	PROPN
admet-441	210	21	,	,	PUNCT
admet-441	210	22	y.	y.	PROPN
admet-441	210	23	sugiyama	sugiyama	PROPN
admet-441	210	24	.	.	PUNCT
admet-441	211	1	comparison	comparison	NOUN
admet-441	211	2	of	of	ADP
admet-441	211	3	methods	method	NOUN
admet-441	211	4	for	for	ADP
admet-441	211	5	estimating	estimate	VERB
admet-441	211	6	unbound	unbound	NOUN
admet-441	211	7	intracellular	intracellular	NOUN
admet-441	211	8	-	-	PUNCT
admet-441	211	9	to	to	ADP
admet-441	211	10	-	-	PUNCT
admet-441	211	11	medium	medium	NOUN
admet-441	211	12	concentration	concentration	NOUN
admet-441	211	13	ratios	ratio	NOUN
admet-441	211	14	in	in	ADP
admet-441	211	15	rat	rat	NOUN
admet-441	211	16	and	and	CCONJ
admet-441	211	17	human	human	ADJ
admet-441	211	18	hepatocytes	hepatocyte	NOUN
admet-441	211	19	using	use	VERB
admet-441	211	20	statins	statin	NOUN
admet-441	211	21	.	.	PUNCT
admet-441	212	1	drug	drug	NOUN
admet-441	212	2	metab	metab	PROPN
admet-441	212	3	dispos	dispos	PROPN
admet-441	212	4	45	45	NUM
admet-441	212	5	(	(	PUNCT
admet-441	212	6	2017	2017	NUM
admet-441	212	7	)	)	PUNCT
admet-441	212	8	779	779	NUM
admet-441	212	9	-	-	SYM
admet-441	212	10	789	789	NUM
admet-441	212	11	.	.	PUNCT
admet-441	213	1	[	[	X
admet-441	213	2	24	24	NUM
admet-441	213	3	]	]	X
admet-441	213	4	m.k	m.k	PROPN
admet-441	213	5	.	.	PROPN
admet-441	213	6	degorter	degorter	PROPN
admet-441	213	7	,	,	PUNCT
admet-441	213	8	r.b	r.b	PROPN
admet-441	213	9	.	.	PROPN
admet-441	213	10	kim	kim	PROPN
admet-441	213	11	.	.	PUNCT
admet-441	214	1	use	use	NOUN
admet-441	214	2	of	of	ADP
admet-441	214	3	transgenic	transgenic	NOUN
admet-441	214	4	and	and	CCONJ
admet-441	214	5	knockout	knockout	NOUN
admet-441	214	6	mouse	mouse	NOUN
admet-441	214	7	models	model	NOUN
admet-441	214	8	to	to	PART
admet-441	214	9	assess	assess	VERB
admet-441	214	10	solute	solute	NOUN
admet-441	214	11	carrier	carrier	NOUN
admet-441	214	12	transporter	transporter	NOUN
admet-441	214	13	function	function	NOUN
admet-441	214	14	.	.	PUNCT
admet-441	215	1	clin	clin	PROPN
admet-441	215	2	pharmacol	pharmacol	PROPN
admet-441	215	3	ther	ther	ADV
admet-441	215	4	89	89	NUM
admet-441	215	5	(	(	PUNCT
admet-441	215	6	2011	2011	NUM
admet-441	215	7	)	)	PUNCT
admet-441	215	8	612	612	NUM
admet-441	215	9	-	-	SYM
admet-441	215	10	616	616	NUM
admet-441	215	11	.	.	PUNCT
admet-441	216	1	[	[	X
admet-441	216	2	25	25	NUM
admet-441	216	3	]	]	X
admet-441	216	4	a.h	a.h	PROPN
admet-441	216	5	.	.	PROPN
admet-441	216	6	schinkel	schinkel	PROPN
admet-441	216	7	,	,	PUNCT
admet-441	216	8	j.j	j.j	PROPN
admet-441	216	9	.	.	PROPN
admet-441	216	10	smit	smit	PROPN
admet-441	216	11	,	,	PUNCT
admet-441	216	12	o.	o.	PROPN
admet-441	216	13	van	van	PROPN
admet-441	216	14	tellingen	tellingen	PROPN
admet-441	216	15	,	,	PUNCT
admet-441	216	16	j.h	j.h	PROPN
admet-441	216	17	.	.	PROPN
admet-441	216	18	beijnen	beijnen	PROPN
admet-441	216	19	,	,	PUNCT
admet-441	216	20	e.	e.	PROPN
admet-441	216	21	wagenaar	wagenaar	PROPN
admet-441	216	22	,	,	PUNCT
admet-441	216	23	l.	l.	PROPN
admet-441	216	24	van	van	PROPN
admet-441	216	25	deemter	deemter	PROPN
admet-441	216	26	,	,	PUNCT
admet-441	216	27	c.a	c.a	PROPN
admet-441	216	28	.	.	PROPN
admet-441	216	29	mol	mol	PROPN
admet-441	216	30	,	,	PUNCT
admet-441	216	31	m.a	m.a	PROPN
admet-441	216	32	.	.	PROPN
admet-441	216	33	van	van	PROPN
admet-441	216	34	der	der	PROPN
admet-441	216	35	valk	valk	PROPN
admet-441	216	36	,	,	PUNCT
admet-441	216	37	e.c	e.c	PROPN
admet-441	216	38	.	.	PROPN
admet-441	216	39	robanus	robanus	PROPN
admet-441	216	40	-	-	PUNCT
admet-441	216	41	maandag	maandag	PROPN
admet-441	216	42	,	,	PUNCT
admet-441	216	43	h.p	h.p	PROPN
admet-441	216	44	.	.	PROPN
admet-441	216	45	te	te	PROPN
admet-441	216	46	riele	riele	PROPN
admet-441	216	47	,	,	PUNCT
admet-441	216	48	et	et	PROPN
admet-441	216	49	al	al	PROPN
admet-441	216	50	.	.	PUNCT
admet-441	217	1	disruption	disruption	NOUN
admet-441	217	2	of	of	ADP
admet-441	217	3	the	the	DET
admet-441	217	4	mouse	mouse	PROPN
admet-441	217	5	mdr1a	mdr1a	PROPN
admet-441	217	6	pglycoprotein	pglycoprotein	ADJ
admet-441	217	7	gene	gene	NOUN
admet-441	217	8	leads	lead	VERB
admet-441	217	9	to	to	ADP
admet-441	217	10	a	a	DET
admet-441	217	11	deficiency	deficiency	NOUN
admet-441	217	12	in	in	ADP
admet-441	217	13	the	the	DET
admet-441	217	14	blood	blood	NOUN
admet-441	217	15	-	-	PUNCT
admet-441	217	16	brain	brain	NOUN
admet-441	217	17	barrier	barrier	NOUN
admet-441	217	18	and	and	CCONJ
admet-441	217	19	to	to	ADP
admet-441	217	20	increased	increase	VERB
admet-441	217	21	sensitivity	sensitivity	NOUN
admet-441	217	22	to	to	ADP
admet-441	217	23	drugs	drug	NOUN
admet-441	217	24	.	.	PUNCT
admet-441	218	1	cell	cell	NOUN
admet-441	218	2	77	77	NUM
admet-441	218	3	(	(	PUNCT
admet-441	218	4	1994	1994	NUM
admet-441	218	5	)	)	PUNCT
admet-441	218	6	491	491	NUM
admet-441	218	7	-	-	SYM
admet-441	218	8	502	502	NUM
admet-441	218	9	.	.	PUNCT
admet-441	219	1	[	[	X
admet-441	219	2	26	26	NUM
admet-441	219	3	]	]	X
admet-441	219	4	c.b	c.b	PROPN
admet-441	219	5	.	.	PROPN
admet-441	219	6	washington	washington	PROPN
admet-441	219	7	,	,	PUNCT
admet-441	219	8	h.r	h.r	PROPN
admet-441	219	9	.	.	PROPN
admet-441	219	10	wiltshire	wiltshire	PROPN
admet-441	219	11	,	,	PUNCT
admet-441	219	12	m.	m.	NOUN
admet-441	219	13	man	man	NOUN
admet-441	219	14	,	,	PUNCT
admet-441	219	15	t.	t.	PROPN
admet-441	219	16	moy	moy	PROPN
admet-441	219	17	,	,	PUNCT
admet-441	219	18	s.r	s.r	PROPN
admet-441	219	19	.	.	PROPN
admet-441	219	20	harris	harris	PROPN
admet-441	219	21	,	,	PUNCT
admet-441	219	22	e.	e.	PROPN
admet-441	219	23	worth	worth	PROPN
admet-441	219	24	,	,	PUNCT
admet-441	219	25	p.	p.	PROPN
admet-441	219	26	weigl	weigl	PROPN
admet-441	219	27	,	,	PUNCT
admet-441	219	28	z.	z.	PROPN
admet-441	219	29	liang	liang	PROPN
admet-441	219	30	,	,	PUNCT
admet-441	219	31	d.	d.	PROPN
admet-441	219	32	hall	hall	PROPN
admet-441	219	33	,	,	PUNCT
admet-441	219	34	l.	l.	PROPN
admet-441	219	35	marriott	marriott	PROPN
admet-441	219	36	,	,	PUNCT
admet-441	219	37	t.f	t.f	PROPN
admet-441	219	38	.	.	PROPN
admet-441	219	39	blaschke	blaschke	PROPN
admet-441	219	40	.	.	PUNCT
admet-441	220	1	the	the	DET
admet-441	220	2	disposition	disposition	NOUN
admet-441	220	3	of	of	ADP
admet-441	220	4	saquinavir	saquinavir	NOUN
admet-441	220	5	in	in	ADP
admet-441	220	6	normal	normal	ADJ
admet-441	220	7	and	and	CCONJ
admet-441	220	8	p	p	ADJ
admet-441	220	9	-	-	PUNCT
admet-441	220	10	glycoprotein	glycoprotein	ADJ
admet-441	220	11	deficient	deficient	ADJ
admet-441	220	12	mice	mouse	NOUN
admet-441	220	13	,	,	PUNCT
admet-441	220	14	rats	rat	NOUN
admet-441	220	15	,	,	PUNCT
admet-441	220	16	and	and	CCONJ
admet-441	220	17	in	in	ADP
admet-441	220	18	cultured	cultured	ADJ
admet-441	220	19	cells	cell	NOUN
admet-441	220	20	.	.	PUNCT
admet-441	221	1	drug	drug	NOUN
admet-441	221	2	metab	metab	PROPN
admet-441	221	3	dispos	dispos	PROPN
admet-441	221	4	28	28	NUM
admet-441	221	5	(	(	PUNCT
admet-441	221	6	2000	2000	NUM
admet-441	221	7	)	)	PUNCT
admet-441	221	8	1058	1058	NUM
admet-441	221	9	-	-	SYM
admet-441	221	10	1062	1062	NUM
admet-441	221	11	.	.	PUNCT
admet-441	222	1	[	[	X
admet-441	222	2	27	27	NUM
admet-441	222	3	]	]	X
admet-441	222	4	a.h	a.h	PROPN
admet-441	222	5	.	.	PROPN
admet-441	222	6	schinkel	schinkel	PROPN
admet-441	222	7	,	,	PUNCT
admet-441	222	8	u.	u.	PROPN
admet-441	222	9	mayer	mayer	PROPN
admet-441	222	10	,	,	PUNCT
admet-441	222	11	e.	e.	PROPN
admet-441	222	12	wagenaar	wagenaar	PROPN
admet-441	222	13	,	,	PUNCT
admet-441	222	14	c.a	c.a	PROPN
admet-441	222	15	.	.	PROPN
admet-441	222	16	mol	mol	PROPN
admet-441	222	17	,	,	PUNCT
admet-441	222	18	l.	l.	PROPN
admet-441	222	19	van	van	PROPN
admet-441	222	20	deemter	deemter	PROPN
admet-441	222	21	,	,	PUNCT
admet-441	222	22	j.j	j.j	PROPN
admet-441	222	23	.	.	PROPN
admet-441	222	24	smit	smit	PROPN
admet-441	222	25	,	,	PUNCT
admet-441	222	26	m.a	m.a	PROPN
admet-441	222	27	.	.	PROPN
admet-441	222	28	van	van	PROPN
admet-441	222	29	der	der	PROPN
admet-441	222	30	valk	valk	PROPN
admet-441	222	31	,	,	PUNCT
admet-441	222	32	a.c	a.c	PROPN
admet-441	222	33	.	.	PROPN
admet-441	222	34	voordouw	voordouw	PROPN
admet-441	222	35	,	,	PUNCT
admet-441	222	36	h.	h.	PROPN
admet-441	222	37	spits	spit	VERB
admet-441	222	38	,	,	PUNCT
admet-441	222	39	o.	o.	PROPN
admet-441	222	40	van	van	PROPN
admet-441	222	41	tellingen	tellingen	PROPN
admet-441	222	42	,	,	PUNCT
admet-441	222	43	j.m	j.m	PROPN
admet-441	222	44	.	.	PROPN
admet-441	222	45	zijlmans	zijlmans	PROPN
admet-441	222	46	,	,	PUNCT
admet-441	222	47	w.e	w.e	PROPN
admet-441	222	48	.	.	PROPN
admet-441	222	49	fibbe	fibbe	NOUN
admet-441	222	50	,	,	PUNCT
admet-441	222	51	p.	p.	NOUN
admet-441	222	52	borst	borst	PROPN
admet-441	222	53	.	.	PUNCT
admet-441	223	1	normal	normal	ADJ
admet-441	223	2	viability	viability	NOUN
admet-441	223	3	and	and	CCONJ
admet-441	223	4	altered	alter	VERB
admet-441	223	5	pharmacokinetics	pharmacokinetic	NOUN
admet-441	223	6	in	in	ADP
admet-441	223	7	mice	mouse	NOUN
admet-441	223	8	lacking	lack	VERB
admet-441	223	9	mdr1	mdr1	PROPN
admet-441	223	10	-	-	PUNCT
admet-441	223	11	type	type	NOUN
admet-441	223	12	(	(	PUNCT
admet-441	223	13	drug	drug	NOUN
admet-441	223	14	-	-	PUNCT
admet-441	223	15	transporting	transporting	NOUN
admet-441	223	16	)	)	PUNCT
admet-441	223	17	p	p	NOUN
admet-441	223	18	-	-	PUNCT
admet-441	223	19	glycoproteins	glycoprotein	NOUN
admet-441	223	20	.	.	PUNCT
admet-441	224	1	proc	proc	PROPN
admet-441	224	2	natl	natl	PROPN
admet-441	224	3	acad	acad	PROPN
admet-441	224	4	sci	sci	PROPN
admet-441	224	5	u	u	PROPN
admet-441	224	6	s	s	PROPN
admet-441	224	7	a	a	DET
admet-441	224	8	94	94	NUM
admet-441	224	9	(	(	PUNCT
admet-441	224	10	1997	1997	NUM
admet-441	224	11	)	)	PUNCT
admet-441	224	12	4028	4028	NUM
admet-441	224	13	-	-	SYM
admet-441	224	14	4033	4033	NUM
admet-441	224	15	.	.	PUNCT
admet-441	225	1	[	[	X
admet-441	225	2	28	28	NUM
admet-441	225	3	]	]	X
admet-441	225	4	j.w	j.w	PROPN
admet-441	225	5	.	.	PROPN
admet-441	225	6	polli	polli	PROPN
admet-441	225	7	,	,	PUNCT
admet-441	225	8	j.l	j.l	PROPN
admet-441	225	9	.	.	PROPN
admet-441	225	10	jarrett	jarrett	PROPN
admet-441	225	11	,	,	PUNCT
admet-441	225	12	s.d	s.d	PROPN
admet-441	225	13	.	.	PROPN
admet-441	225	14	studenberg	studenberg	PROPN
admet-441	225	15	,	,	PUNCT
admet-441	225	16	j.e	j.e	PROPN
admet-441	225	17	.	.	PROPN
admet-441	225	18	humphreys	humphreys	PROPN
admet-441	225	19	,	,	PUNCT
admet-441	225	20	s.w	s.w	PROPN
admet-441	225	21	.	.	PROPN
admet-441	225	22	dennis	dennis	PROPN
admet-441	225	23	,	,	PUNCT
admet-441	225	24	k.r	k.r	PROPN
admet-441	225	25	.	.	PROPN
admet-441	225	26	brouwer	brouwer	PROPN
admet-441	225	27	,	,	PUNCT
admet-441	225	28	j.l	j.l	PROPN
admet-441	225	29	.	.	PROPN
admet-441	225	30	woolley	woolley	PROPN
admet-441	225	31	.	.	PUNCT
admet-441	226	1	role	role	NOUN
admet-441	226	2	of	of	ADP
admet-441	226	3	p	p	NOUN
admet-441	226	4	-	-	PUNCT
admet-441	226	5	glycoprotein	glycoprotein	NOUN
admet-441	226	6	on	on	ADP
admet-441	226	7	the	the	DET
admet-441	226	8	cns	cns	NOUN
admet-441	226	9	disposition	disposition	NOUN
admet-441	226	10	of	of	ADP
admet-441	226	11	amprenavir	amprenavir	PROPN
admet-441	226	12	(	(	PUNCT
admet-441	226	13	141w94	141w94	NUM
admet-441	226	14	)	)	PUNCT
admet-441	226	15	,	,	PUNCT
admet-441	226	16	an	an	DET
admet-441	226	17	hiv	hiv	PROPN
admet-441	226	18	protease	protease	NOUN
admet-441	226	19	inhibitor	inhibitor	NOUN
admet-441	226	20	.	.	PUNCT
admet-441	227	1	pharm	pharm	NOUN
admet-441	227	2	res	re	VERB
admet-441	227	3	16	16	NUM
admet-441	227	4	(	(	PUNCT
admet-441	227	5	1999	1999	NUM
admet-441	227	6	)	)	PUNCT
admet-441	227	7	1206	1206	NUM
admet-441	227	8	-	-	SYM
admet-441	227	9	1212	1212	NUM
admet-441	227	10	.	.	PUNCT
admet-441	228	1	[	[	X
admet-441	228	2	29	29	NUM
admet-441	228	3	]	]	X
admet-441	228	4	y.	y.	PROPN
admet-441	228	5	zhang	zhang	PROPN
admet-441	228	6	,	,	PUNCT
admet-441	228	7	c.	c.	PROPN
admet-441	228	8	bachmeier	bachmeier	NOUN
admet-441	228	9	,	,	PUNCT
admet-441	228	10	d.w	d.w	PROPN
admet-441	228	11	.	.	PROPN
admet-441	228	12	miller	miller	PROPN
admet-441	228	13	.	.	PUNCT
admet-441	229	1	in	in	ADP
admet-441	229	2	vitro	vitro	X
admet-441	229	3	and	and	CCONJ
admet-441	229	4	in	in	ADP
admet-441	229	5	vivo	vivo	NOUN
admet-441	229	6	models	model	NOUN
admet-441	229	7	for	for	ADP
admet-441	229	8	assessing	assess	VERB
admet-441	229	9	drug	drug	NOUN
admet-441	229	10	efflux	efflux	NOUN
admet-441	229	11	transporter	transporter	NOUN
admet-441	229	12	activity	activity	NOUN
admet-441	229	13	.	.	PUNCT
admet-441	230	1	adv	adv	PROPN
admet-441	230	2	drug	drug	PROPN
admet-441	230	3	deliv	deliv	NOUN
admet-441	230	4	rev	rev	VERB
admet-441	230	5	55	55	NUM
admet-441	230	6	(	(	PUNCT
admet-441	230	7	2003	2003	NUM
admet-441	230	8	)	)	PUNCT
admet-441	230	9	31	31	NUM
admet-441	230	10	-	-	SYM
admet-441	230	11	51	51	NUM
admet-441	230	12	.	.	PUNCT
admet-441	231	1	[	[	X
admet-441	231	2	30	30	NUM
admet-441	231	3	]	]	X
admet-441	231	4	m.	m.	NOUN
admet-441	231	5	yamazaki	yamazaki	PROPN
admet-441	231	6	,	,	PUNCT
admet-441	231	7	w.e	w.e	PROPN
admet-441	231	8	.	.	PROPN
admet-441	231	9	neway	neway	PROPN
admet-441	231	10	,	,	PUNCT
admet-441	231	11	t.	t.	PROPN
admet-441	231	12	ohe	ohe	PROPN
admet-441	231	13	,	,	PUNCT
admet-441	231	14	i.	i.	PROPN
admet-441	231	15	chen	chen	PROPN
admet-441	231	16	,	,	PUNCT
admet-441	231	17	j.f	j.f	PROPN
admet-441	231	18	.	.	PROPN
admet-441	231	19	rowe	rowe	PROPN
admet-441	231	20	,	,	PUNCT
admet-441	231	21	j.h	j.h	PROPN
admet-441	231	22	.	.	PROPN
admet-441	231	23	hochman	hochman	PROPN
admet-441	231	24	,	,	PUNCT
admet-441	231	25	m.	m.	PROPN
admet-441	231	26	chiba	chiba	PROPN
admet-441	231	27	,	,	PUNCT
admet-441	231	28	j.h	j.h	PROPN
admet-441	231	29	.	.	PROPN
admet-441	231	30	lin	lin	PROPN
admet-441	231	31	.	.	PUNCT
admet-441	232	1	in	in	ADP
admet-441	232	2	vitro	vitro	X
admet-441	232	3	substrate	substrate	NOUN
admet-441	232	4	identification	identification	NOUN
admet-441	232	5	studies	study	NOUN
admet-441	232	6	for	for	ADP
admet-441	232	7	p	p	NOUN
admet-441	232	8	-	-	PUNCT
admet-441	232	9	glycoprotein	glycoprotein	NOUN
admet-441	232	10	-	-	PUNCT
admet-441	232	11	mediated	mediate	VERB
admet-441	232	12	transport	transport	NOUN
admet-441	232	13	:	:	PUNCT
admet-441	232	14	species	species	NOUN
admet-441	232	15	difference	difference	NOUN
admet-441	232	16	and	and	CCONJ
admet-441	232	17	predictability	predictability	NOUN
admet-441	232	18	of	of	ADP
admet-441	232	19	in	in	ADP
admet-441	232	20	vivo	vivo	NOUN
admet-441	232	21	results	result	NOUN
admet-441	232	22	.	.	PUNCT
admet-441	233	1	j	j	PROPN
admet-441	233	2	pharmacol	pharmacol	PROPN
admet-441	233	3	exp	exp	NOUN
admet-441	233	4	ther	ther	ADV
admet-441	233	5	296	296	NUM
admet-441	233	6	(	(	PUNCT
admet-441	233	7	2001	2001	NUM
admet-441	233	8	)	)	PUNCT
admet-441	233	9	723	723	NUM
admet-441	233	10	-	-	SYM
admet-441	233	11	735	735	NUM
admet-441	233	12	.	.	PUNCT
admet-441	234	1	admet	admet	PROPN
admet-441	234	2	&	&	CCONJ
admet-441	234	3	dmpk	dmpk	PROPN
admet-441	234	4	5(4	5(4	NOUN
admet-441	234	5	)	)	PUNCT
admet-441	234	6	(	(	PUNCT
admet-441	234	7	2017	2017	NUM
admet-441	234	8	)	)	PUNCT
admet-441	234	9	201	201	NUM
admet-441	234	10	-	-	SYM
admet-441	234	11	211	211	NUM
admet-441	234	12	utilizing	utilize	VERB
admet-441	234	13	in	in	ADP
admet-441	234	14	vitro	vitro	X
admet-441	234	15	transporter	transporter	NOUN
admet-441	234	16	data	datum	NOUN
admet-441	234	17	in	in	ADP
admet-441	234	18	ivive	ivive	ADJ
admet-441	234	19	-	-	PUNCT
admet-441	234	20	pbpk	pbpk	ADJ
admet-441	234	21	doi	doi	NOUN
admet-441	234	22	:	:	PUNCT
admet-441	234	23	10.5599	10.5599	NUM
admet-441	234	24	/	/	SYM
admet-441	234	25	admet.5.4.441	admet.5.4.441	NUM
admet-441	234	26	209	209	NUM
admet-441	235	1	[	[	X
admet-441	235	2	31	31	NUM
admet-441	235	3	]	]	X
admet-441	235	4	j.b	j.b	PROPN
admet-441	235	5	.	.	PROPN
admet-441	235	6	houston	houston	PROPN
admet-441	235	7	,	,	PUNCT
admet-441	235	8	a.	a.	NOUN
admet-441	235	9	galetin	galetin	PROPN
admet-441	235	10	.	.	PUNCT
admet-441	236	1	methods	method	NOUN
admet-441	236	2	for	for	ADP
admet-441	236	3	predicting	predict	VERB
admet-441	236	4	in	in	ADP
admet-441	236	5	vivo	vivo	ADJ
admet-441	236	6	pharmacokinetics	pharmacokinetic	NOUN
admet-441	236	7	using	use	VERB
admet-441	236	8	data	datum	NOUN
admet-441	236	9	from	from	ADP
admet-441	236	10	in	in	ADP
admet-441	236	11	vitro	vitro	X
admet-441	236	12	assays	assay	NOUN
admet-441	236	13	.	.	PUNCT
admet-441	237	1	curr	curr	PROPN
admet-441	237	2	drug	drug	PROPN
admet-441	237	3	metab	metab	PROPN
admet-441	237	4	9	9	NUM
admet-441	237	5	(	(	PUNCT
admet-441	237	6	2008	2008	NUM
admet-441	237	7	)	)	PUNCT
admet-441	237	8	940	940	NUM
admet-441	237	9	-	-	SYM
admet-441	237	10	951	951	NUM
admet-441	237	11	.	.	PUNCT
admet-441	238	1	[	[	X
admet-441	238	2	32	32	NUM
admet-441	238	3	]	]	X
admet-441	238	4	j.o	j.o	PROPN
admet-441	238	5	.	.	PROPN
admet-441	238	6	miners	miner	NOUN
admet-441	238	7	,	,	PUNCT
admet-441	238	8	p.i	p.i	PROPN
admet-441	238	9	.	.	PROPN
admet-441	238	10	mackenzie	mackenzie	PROPN
admet-441	238	11	,	,	PUNCT
admet-441	238	12	k.m	k.m	PROPN
admet-441	238	13	.	.	PROPN
admet-441	238	14	knights	knights	PROPN
admet-441	238	15	.	.	PUNCT
admet-441	239	1	the	the	DET
admet-441	239	2	prediction	prediction	NOUN
admet-441	239	3	of	of	ADP
admet-441	239	4	drug	drug	NOUN
admet-441	239	5	-	-	PUNCT
admet-441	239	6	glucuronidation	glucuronidation	NOUN
admet-441	239	7	parameters	parameter	NOUN
admet-441	239	8	in	in	ADP
admet-441	239	9	humans	human	NOUN
admet-441	239	10	:	:	PUNCT
admet-441	239	11	udp	udp	NOUN
admet-441	239	12	-	-	NOUN
admet-441	239	13	glucuronosyltransferase	glucuronosyltransferase	ADJ
admet-441	239	14	enzyme	enzyme	NOUN
admet-441	239	15	-	-	PUNCT
admet-441	239	16	selective	selective	ADJ
admet-441	239	17	substrate	substrate	NOUN
admet-441	239	18	and	and	CCONJ
admet-441	239	19	inhibitor	inhibitor	NOUN
admet-441	239	20	probes	probe	NOUN
admet-441	239	21	for	for	ADP
admet-441	239	22	reaction	reaction	NOUN
admet-441	239	23	phenotyping	phenotyping	NOUN
admet-441	239	24	and	and	CCONJ
admet-441	239	25	in	in	ADP
admet-441	239	26	vitro	vitro	X
admet-441	239	27	-	-	PUNCT
admet-441	239	28	in	in	ADP
admet-441	239	29	vivo	vivo	ADJ
admet-441	239	30	extrapolation	extrapolation	NOUN
admet-441	239	31	of	of	ADP
admet-441	239	32	drug	drug	NOUN
admet-441	239	33	clearance	clearance	NOUN
admet-441	239	34	and	and	CCONJ
admet-441	239	35	drug	drug	NOUN
admet-441	239	36	-	-	PUNCT
admet-441	239	37	drug	drug	NOUN
admet-441	239	38	interaction	interaction	NOUN
admet-441	239	39	potential	potential	NOUN
admet-441	239	40	.	.	PUNCT
admet-441	240	1	drug	drug	NOUN
admet-441	240	2	metab	metab	PROPN
admet-441	240	3	rev	rev	VERB
admet-441	240	4	42	42	NUM
admet-441	240	5	(	(	PUNCT
admet-441	240	6	2010	2010	NUM
admet-441	240	7	)	)	PUNCT
admet-441	240	8	196	196	NUM
admet-441	240	9	-	-	SYM
admet-441	240	10	208	208	NUM
admet-441	240	11	.	.	PUNCT
admet-441	241	1	[	[	X
admet-441	241	2	33	33	NUM
admet-441	241	3	]	]	X
admet-441	241	4	h.m	h.m	PROPN
admet-441	241	5	.	.	PROPN
admet-441	241	6	jones	jones	PROPN
admet-441	241	7	,	,	PUNCT
admet-441	241	8	h.a	h.a	PROPN
admet-441	241	9	.	.	PROPN
admet-441	241	10	barton	barton	PROPN
admet-441	241	11	,	,	PUNCT
admet-441	241	12	y.	y.	PROPN
admet-441	241	13	lai	lai	PROPN
admet-441	241	14	,	,	PUNCT
admet-441	241	15	y.a	y.a	PROPN
admet-441	241	16	.	.	PROPN
admet-441	241	17	bi	bi	PROPN
admet-441	241	18	,	,	PUNCT
admet-441	241	19	e.	e.	PROPN
admet-441	241	20	kimoto	kimoto	PROPN
admet-441	241	21	,	,	PUNCT
admet-441	241	22	s.	s.	PROPN
admet-441	241	23	kempshall	kempshall	PROPN
admet-441	241	24	,	,	PUNCT
admet-441	241	25	s.c	s.c	PROPN
admet-441	241	26	.	.	PROPN
admet-441	241	27	tate	tate	PROPN
admet-441	241	28	,	,	PUNCT
admet-441	241	29	a.	a.	PROPN
admet-441	241	30	el	el	PROPN
admet-441	241	31	-	-	PUNCT
admet-441	241	32	kattan	kattan	PROPN
admet-441	241	33	,	,	PUNCT
admet-441	241	34	j.b	j.b	PROPN
admet-441	241	35	.	.	PROPN
admet-441	241	36	houston	houston	PROPN
admet-441	241	37	,	,	PUNCT
admet-441	241	38	a.	a.	NOUN
admet-441	241	39	galetin	galetin	PROPN
admet-441	241	40	,	,	PUNCT
admet-441	241	41	k.s	k.s	PROPN
admet-441	241	42	.	.	PROPN
admet-441	241	43	fenner	fenner	PROPN
admet-441	241	44	.	.	PUNCT
admet-441	242	1	mechanistic	mechanistic	ADJ
admet-441	242	2	pharmacokinetic	pharmacokinetic	ADJ
admet-441	242	3	modeling	modeling	NOUN
admet-441	242	4	for	for	ADP
admet-441	242	5	the	the	DET
admet-441	242	6	prediction	prediction	NOUN
admet-441	242	7	of	of	ADP
admet-441	242	8	transportermediated	transportermediated	ADJ
admet-441	242	9	disposition	disposition	NOUN
admet-441	242	10	in	in	ADP
admet-441	242	11	humans	human	NOUN
admet-441	242	12	from	from	ADP
admet-441	242	13	sandwich	sandwich	NOUN
admet-441	242	14	culture	culture	PROPN
admet-441	242	15	human	human	PROPN
admet-441	242	16	hepatocyte	hepatocyte	PROPN
admet-441	242	17	data	data	PROPN
admet-441	242	18	.	.	PUNCT
admet-441	243	1	drug	drug	NOUN
admet-441	243	2	metab	metab	PROPN
admet-441	243	3	dispos	dispos	PROPN
admet-441	243	4	40	40	NUM
admet-441	243	5	(	(	PUNCT
admet-441	243	6	2012	2012	NUM
admet-441	243	7	)	)	PUNCT
admet-441	243	8	1007	1007	NUM
admet-441	243	9	-	-	SYM
admet-441	243	10	1017	1017	NUM
admet-441	243	11	.	.	PUNCT
admet-441	244	1	[	[	X
admet-441	244	2	34	34	NUM
admet-441	244	3	]	]	X
admet-441	244	4	m.j	m.j	PROPN
admet-441	244	5	.	.	PROPN
admet-441	244	6	zamek	zamek	PROPN
admet-441	244	7	-	-	PUNCT
admet-441	244	8	gliszczynski	gliszczynski	PROPN
admet-441	244	9	,	,	PUNCT
admet-441	244	10	c.a	c.a	PROPN
admet-441	244	11	.	.	PROPN
admet-441	244	12	lee	lee	PROPN
admet-441	244	13	,	,	PUNCT
admet-441	244	14	a.	a.	NOUN
admet-441	244	15	poirier	poirier	PROPN
admet-441	244	16	,	,	PUNCT
admet-441	244	17	j.	j.	PROPN
admet-441	244	18	bentz	bentz	PROPN
admet-441	244	19	,	,	PUNCT
admet-441	244	20	x.	x.	PROPN
admet-441	244	21	chu	chu	PROPN
admet-441	244	22	,	,	PUNCT
admet-441	244	23	h.	h.	PROPN
admet-441	244	24	ellens	ellens	PROPN
admet-441	244	25	,	,	PUNCT
admet-441	244	26	t.	t.	PROPN
admet-441	244	27	ishikawa	ishikawa	PROPN
admet-441	244	28	,	,	PUNCT
admet-441	244	29	m.	m.	NOUN
admet-441	244	30	jamei	jamei	PROPN
admet-441	244	31	,	,	PUNCT
admet-441	244	32	j.c	j.c	PROPN
admet-441	244	33	.	.	PROPN
admet-441	244	34	kalvass	kalvass	PROPN
admet-441	244	35	,	,	PUNCT
admet-441	244	36	s.	s.	PROPN
admet-441	244	37	nagar	nagar	PROPN
admet-441	244	38	,	,	PUNCT
admet-441	244	39	k.s	k.s	PROPN
admet-441	244	40	.	.	PROPN
admet-441	244	41	pang	pang	PROPN
admet-441	244	42	,	,	PUNCT
admet-441	244	43	k.	k.	PROPN
admet-441	244	44	korzekwa	korzekwa	PROPN
admet-441	244	45	,	,	PUNCT
admet-441	244	46	p.w	p.w	PROPN
admet-441	244	47	.	.	PROPN
admet-441	244	48	swaan	swaan	PROPN
admet-441	244	49	,	,	PUNCT
admet-441	244	50	m.e	m.e	PROPN
admet-441	244	51	.	.	PROPN
admet-441	244	52	taub	taub	PROPN
admet-441	244	53	,	,	PUNCT
admet-441	244	54	p.	p.	PROPN
admet-441	244	55	zhao	zhao	PROPN
admet-441	244	56	,	,	PUNCT
admet-441	244	57	a.	a.	NOUN
admet-441	244	58	galetin	galetin	PROPN
admet-441	244	59	,	,	PUNCT
admet-441	244	60	c.	c.	PROPN
admet-441	244	61	international	international	ADJ
admet-441	244	62	transporter	transporter	NOUN
admet-441	244	63	.	.	PUNCT
admet-441	245	1	itc	itc	NOUN
admet-441	245	2	recommendations	recommendation	NOUN
admet-441	245	3	for	for	ADP
admet-441	245	4	transporter	transporter	NOUN
admet-441	245	5	kinetic	kinetic	ADJ
admet-441	245	6	parameter	parameter	NOUN
admet-441	245	7	estimation	estimation	NOUN
admet-441	245	8	and	and	CCONJ
admet-441	245	9	translational	translational	ADJ
admet-441	245	10	modeling	modeling	NOUN
admet-441	245	11	of	of	ADP
admet-441	245	12	transport	transport	NOUN
admet-441	245	13	-	-	PUNCT
admet-441	245	14	mediated	mediate	VERB
admet-441	245	15	pk	pk	NOUN
admet-441	245	16	and	and	CCONJ
admet-441	245	17	ddis	ddi	NOUN
admet-441	245	18	in	in	ADP
admet-441	245	19	humans	human	NOUN
admet-441	245	20	.	.	PUNCT
admet-441	246	1	clin	clin	PROPN
admet-441	246	2	pharmacol	pharmacol	PROPN
admet-441	246	3	ther	ther	ADV
admet-441	246	4	94	94	NUM
admet-441	246	5	(	(	PUNCT
admet-441	246	6	2013	2013	NUM
admet-441	246	7	)	)	PUNCT
admet-441	246	8	64	64	NUM
admet-441	246	9	-	-	SYM
admet-441	246	10	79	79	NUM
admet-441	246	11	.	.	PUNCT
admet-441	247	1	[	[	X
admet-441	247	2	35	35	NUM
admet-441	247	3	]	]	X
admet-441	247	4	s.	s.	PROPN
admet-441	247	5	bosgra	bosgra	PROPN
admet-441	247	6	,	,	PUNCT
admet-441	247	7	e.	e.	PROPN
admet-441	247	8	van	van	PROPN
admet-441	247	9	de	de	PROPN
admet-441	247	10	steeg	steeg	PROPN
admet-441	247	11	,	,	PUNCT
admet-441	247	12	m.l	m.l	PROPN
admet-441	247	13	.	.	PROPN
admet-441	247	14	vlaming	vlaming	PROPN
admet-441	247	15	,	,	PUNCT
admet-441	247	16	k.c	k.c	PROPN
admet-441	247	17	.	.	PROPN
admet-441	247	18	verhoeckx	verhoeckx	PROPN
admet-441	247	19	,	,	PUNCT
admet-441	247	20	m.t	m.t	PROPN
admet-441	247	21	.	.	PROPN
admet-441	247	22	huisman	huisman	PROPN
admet-441	247	23	,	,	PUNCT
admet-441	247	24	m.	m.	NOUN
admet-441	247	25	verwei	verwei	PROPN
admet-441	247	26	,	,	PUNCT
admet-441	247	27	h.m	h.m	PROPN
admet-441	247	28	.	.	PROPN
admet-441	247	29	wortelboer	wortelboer	PROPN
admet-441	247	30	.	.	PUNCT
admet-441	248	1	predicting	predict	VERB
admet-441	248	2	carrier	carrier	NOUN
admet-441	248	3	-	-	PUNCT
admet-441	248	4	mediated	mediate	VERB
admet-441	248	5	hepatic	hepatic	ADJ
admet-441	248	6	disposition	disposition	NOUN
admet-441	248	7	of	of	ADP
admet-441	248	8	rosuvastatin	rosuvastatin	NOUN
admet-441	248	9	in	in	ADP
admet-441	248	10	man	man	NOUN
admet-441	248	11	by	by	ADP
admet-441	248	12	scaling	scale	VERB
admet-441	248	13	from	from	ADP
admet-441	248	14	individual	individual	ADJ
admet-441	248	15	transfected	transfecte	VERB
admet-441	248	16	cell	cell	NOUN
admet-441	248	17	-	-	PUNCT
admet-441	248	18	lines	line	NOUN
admet-441	248	19	in	in	ADP
admet-441	248	20	vitro	vitro	X
admet-441	248	21	using	use	VERB
admet-441	248	22	absolute	absolute	ADJ
admet-441	248	23	transporter	transporter	NOUN
admet-441	248	24	protein	protein	NOUN
admet-441	248	25	quantification	quantification	NOUN
admet-441	248	26	and	and	CCONJ
admet-441	248	27	pbpk	pbpk	NOUN
admet-441	248	28	modeling	modeling	NOUN
admet-441	248	29	.	.	PUNCT
admet-441	249	1	eur	eur	PROPN
admet-441	249	2	j	j	PROPN
admet-441	249	3	pharm	pharm	PROPN
admet-441	249	4	sci	sci	PROPN
admet-441	249	5	65	65	NUM
admet-441	249	6	(	(	PUNCT
admet-441	249	7	2014	2014	NUM
admet-441	249	8	)	)	PUNCT
admet-441	249	9	156	156	NUM
admet-441	249	10	-	-	SYM
admet-441	249	11	166	166	NUM
admet-441	249	12	.	.	PUNCT
admet-441	250	1	[	[	X
admet-441	250	2	36	36	NUM
admet-441	250	3	]	]	X
admet-441	250	4	s.	s.	PROPN
admet-441	250	5	neuhoff	neuhoff	PROPN
admet-441	250	6	,	,	PUNCT
admet-441	250	7	k.r	k.r	PROPN
admet-441	250	8	.	.	PROPN
admet-441	250	9	yeo	yeo	PROPN
admet-441	250	10	,	,	PUNCT
admet-441	250	11	z.	z.	PROPN
admet-441	250	12	barter	barter	PROPN
admet-441	250	13	,	,	PUNCT
admet-441	250	14	m.	m.	PROPN
admet-441	250	15	jamei	jamei	PROPN
admet-441	250	16	,	,	PUNCT
admet-441	250	17	d.b	d.b	PROPN
admet-441	250	18	.	.	PROPN
admet-441	250	19	turner	turner	PROPN
admet-441	250	20	,	,	PUNCT
admet-441	250	21	a.	a.	PROPN
admet-441	250	22	rostami	rostami	PROPN
admet-441	250	23	-	-	PUNCT
admet-441	250	24	hodjegan	hodjegan	PROPN
admet-441	250	25	.	.	PUNCT
admet-441	250	26	application	application	NOUN
admet-441	250	27	of	of	ADP
admet-441	250	28	permeability	permeability	NOUN
admet-441	250	29	-	-	PUNCT
admet-441	250	30	limited	limit	VERB
admet-441	250	31	physiologically	physiologically	ADV
admet-441	250	32	-	-	PUNCT
admet-441	250	33	based	base	VERB
admet-441	250	34	pharmacokinetic	pharmacokinetic	ADJ
admet-441	250	35	models	model	NOUN
admet-441	250	36	:	:	PUNCT
admet-441	250	37	part	part	NOUN
admet-441	250	38	ii	ii	PROPN
admet-441	250	39	prediction	prediction	NOUN
admet-441	250	40	of	of	ADP
admet-441	250	41	pglycoprotein	pglycoprotein	ADJ
admet-441	250	42	mediated	mediate	VERB
admet-441	250	43	drug	drug	NOUN
admet-441	250	44	-	-	PUNCT
admet-441	250	45	drug	drug	NOUN
admet-441	250	46	interactions	interaction	NOUN
admet-441	250	47	with	with	ADP
admet-441	250	48	digoxin	digoxin	NOUN
admet-441	250	49	.	.	PUNCT
admet-441	251	1	j	j	PROPN
admet-441	251	2	pharm	pharm	PROPN
admet-441	251	3	sci	sci	PROPN
admet-441	251	4	102	102	NUM
admet-441	251	5	(	(	PUNCT
admet-441	251	6	2013	2013	NUM
admet-441	251	7	)	)	PUNCT
admet-441	251	8	3161	3161	NUM
admet-441	251	9	-	-	SYM
admet-441	251	10	3173	3173	NUM
admet-441	251	11	.	.	PUNCT
admet-441	252	1	[	[	X
admet-441	252	2	37	37	NUM
admet-441	252	3	]	]	PUNCT
admet-441	252	4	a.	a.	NOUN
admet-441	252	5	rostami	rostami	PROPN
admet-441	252	6	-	-	PUNCT
admet-441	252	7	hodjegan	hodjegan	PROPN
admet-441	252	8	,	,	PUNCT
admet-441	252	9	g.t	g.t	PROPN
admet-441	252	10	.	.	PROPN
admet-441	252	11	tucker	tucker	PROPN
admet-441	252	12	.	.	PUNCT
admet-441	253	1	simulation	simulation	NOUN
admet-441	253	2	and	and	CCONJ
admet-441	253	3	prediction	prediction	NOUN
admet-441	253	4	of	of	ADP
admet-441	253	5	in	in	ADP
admet-441	253	6	vivo	vivo	ADJ
admet-441	253	7	drug	drug	NOUN
admet-441	253	8	metabolism	metabolism	NOUN
admet-441	253	9	in	in	ADP
admet-441	253	10	human	human	ADJ
admet-441	253	11	populations	population	NOUN
admet-441	253	12	from	from	ADP
admet-441	253	13	in	in	ADP
admet-441	253	14	vitro	vitro	X
admet-441	253	15	data	datum	NOUN
admet-441	253	16	.	.	PUNCT
admet-441	254	1	nat	nat	PROPN
admet-441	254	2	rev	rev	PROPN
admet-441	254	3	drug	drug	PROPN
admet-441	254	4	discov	discov	PROPN
admet-441	254	5	6	6	NUM
admet-441	254	6	(	(	PUNCT
admet-441	254	7	2007	2007	NUM
admet-441	254	8	)	)	PUNCT
admet-441	254	9	140	140	NUM
admet-441	254	10	-	-	SYM
admet-441	254	11	148	148	NUM
admet-441	254	12	.	.	PUNCT
admet-441	255	1	[	[	X
admet-441	255	2	38	38	NUM
admet-441	255	3	]	]	PUNCT
admet-441	255	4	s.	s.	PROPN
admet-441	255	5	neuhoff	neuhoff	PROPN
admet-441	255	6	,	,	PUNCT
admet-441	255	7	k.r	k.r	PROPN
admet-441	255	8	.	.	PROPN
admet-441	255	9	yeo	yeo	PROPN
admet-441	255	10	,	,	PUNCT
admet-441	255	11	z.	z.	PROPN
admet-441	255	12	barter	barter	PROPN
admet-441	255	13	,	,	PUNCT
admet-441	255	14	m.	m.	PROPN
admet-441	255	15	jamei	jamei	PROPN
admet-441	255	16	,	,	PUNCT
admet-441	255	17	d.b	d.b	PROPN
admet-441	255	18	.	.	PROPN
admet-441	255	19	turner	turner	PROPN
admet-441	255	20	,	,	PUNCT
admet-441	255	21	a.	a.	PROPN
admet-441	255	22	rostami	rostami	PROPN
admet-441	255	23	-	-	PUNCT
admet-441	255	24	hodjegan	hodjegan	PROPN
admet-441	255	25	.	.	PUNCT
admet-441	256	1	application	application	NOUN
admet-441	256	2	of	of	ADP
admet-441	256	3	permeability	permeability	NOUN
admet-441	256	4	-	-	PUNCT
admet-441	256	5	limited	limit	VERB
admet-441	256	6	physiologically	physiologically	ADV
admet-441	256	7	-	-	PUNCT
admet-441	256	8	based	base	VERB
admet-441	256	9	pharmacokinetic	pharmacokinetic	ADJ
admet-441	256	10	models	model	NOUN
admet-441	256	11	:	:	PUNCT
admet-441	256	12	part	part	NOUN
admet-441	256	13	i	i	NOUN
admet-441	256	14	-	-	PUNCT
admet-441	256	15	digoxin	digoxin	NOUN
admet-441	256	16	pharmacokinetics	pharmacokinetic	NOUN
admet-441	256	17	incorporating	incorporate	VERB
admet-441	256	18	p	p	NOUN
admet-441	256	19	-	-	PUNCT
admet-441	256	20	glycoprotein	glycoprotein	NOUN
admet-441	256	21	-	-	PUNCT
admet-441	256	22	mediated	mediate	VERB
admet-441	256	23	efflux	efflux	NOUN
admet-441	256	24	.	.	PUNCT
admet-441	257	1	j	j	PROPN
admet-441	257	2	pharm	pharm	PROPN
admet-441	257	3	sci	sci	PROPN
admet-441	257	4	102	102	NUM
admet-441	257	5	(	(	PUNCT
admet-441	257	6	2013	2013	NUM
admet-441	257	7	)	)	PUNCT
admet-441	257	8	3145	3145	NUM
admet-441	257	9	-	-	SYM
admet-441	257	10	3160	3160	NUM
admet-441	257	11	.	.	PUNCT
admet-441	258	1	[	[	X
admet-441	258	2	39	39	NUM
admet-441	258	3	]	]	X
admet-441	258	4	j.m	j.m	PROPN
admet-441	258	5	.	.	PROPN
admet-441	258	6	dietschy	dietschy	PROPN
admet-441	258	7	.	.	PUNCT
admet-441	259	1	mechanisms	mechanism	NOUN
admet-441	259	2	for	for	ADP
admet-441	259	3	the	the	DET
admet-441	259	4	intestinal	intestinal	ADJ
admet-441	259	5	absorption	absorption	NOUN
admet-441	259	6	of	of	ADP
admet-441	259	7	bile	bile	NOUN
admet-441	259	8	acids	acid	NOUN
admet-441	259	9	.	.	PUNCT
admet-441	260	1	j	j	PROPN
admet-441	260	2	lipid	lipid	PROPN
admet-441	260	3	res	re	VERB
admet-441	260	4	9	9	NUM
admet-441	260	5	(	(	PUNCT
admet-441	260	6	1968	1968	NUM
admet-441	260	7	)	)	PUNCT
admet-441	260	8	297	297	NUM
admet-441	260	9	-	-	SYM
admet-441	260	10	309	309	NUM
admet-441	260	11	.	.	PUNCT
admet-441	261	1	[	[	X
admet-441	261	2	40	40	NUM
admet-441	261	3	]	]	X
admet-441	261	4	s.n	s.n	PROPN
admet-441	261	5	.	.	PROPN
admet-441	261	6	marcus	marcus	PROPN
admet-441	261	7	,	,	PUNCT
admet-441	261	8	c.d	c.d	PROPN
admet-441	261	9	.	.	PROPN
admet-441	261	10	schteingart	schteingart	PROPN
admet-441	261	11	,	,	PUNCT
admet-441	261	12	m.l	m.l	PROPN
admet-441	261	13	.	.	PROPN
admet-441	261	14	marquez	marquez	PROPN
admet-441	261	15	,	,	PUNCT
admet-441	261	16	a.f	a.f	PROPN
admet-441	261	17	.	.	PROPN
admet-441	261	18	hofmann	hofmann	PROPN
admet-441	261	19	,	,	PUNCT
admet-441	261	20	y.	y.	PROPN
admet-441	261	21	xia	xia	PROPN
admet-441	261	22	,	,	PUNCT
admet-441	261	23	j.h	j.h	PROPN
admet-441	261	24	.	.	PROPN
admet-441	261	25	steinbach	steinbach	PROPN
admet-441	261	26	,	,	PUNCT
admet-441	261	27	h.t	h.t	PROPN
admet-441	261	28	.	.	PROPN
admet-441	261	29	ton	ton	PROPN
admet-441	261	30	-	-	PUNCT
admet-441	261	31	nu	nu	PROPN
admet-441	261	32	,	,	PUNCT
admet-441	261	33	j.	j.	PROPN
admet-441	261	34	lillienau	lillienau	PROPN
admet-441	261	35	,	,	PUNCT
admet-441	261	36	m.a	m.a	PROPN
admet-441	261	37	.	.	PROPN
admet-441	261	38	angellotti	angellotti	PROPN
admet-441	261	39	,	,	PUNCT
admet-441	261	40	a.	a.	NOUN
admet-441	261	41	schmassmann	schmassmann	PROPN
admet-441	261	42	.	.	PUNCT
admet-441	262	1	active	active	ADJ
admet-441	262	2	absorption	absorption	NOUN
admet-441	262	3	of	of	ADP
admet-441	262	4	conjugated	conjugated	ADJ
admet-441	262	5	bile	bile	NOUN
admet-441	262	6	acids	acid	NOUN
admet-441	262	7	in	in	ADP
admet-441	262	8	vivo	vivo	NOUN
admet-441	262	9	.	.	PUNCT
admet-441	263	1	kinetic	kinetic	ADJ
admet-441	263	2	parameters	parameter	NOUN
admet-441	263	3	and	and	CCONJ
admet-441	263	4	molecular	molecular	ADJ
admet-441	263	5	specificity	specificity	NOUN
admet-441	263	6	of	of	ADP
admet-441	263	7	the	the	DET
admet-441	263	8	ileal	ileal	ADJ
admet-441	263	9	transport	transport	NOUN
admet-441	263	10	system	system	NOUN
admet-441	263	11	in	in	ADP
admet-441	263	12	the	the	DET
admet-441	263	13	rat	rat	NOUN
admet-441	263	14	.	.	PROPN
admet-441	263	15	gastroenterology	gastroenterology	NOUN
admet-441	263	16	100	100	NUM
admet-441	263	17	(	(	PUNCT
admet-441	263	18	1991	1991	NUM
admet-441	263	19	)	)	PUNCT
admet-441	263	20	212	212	NUM
admet-441	263	21	-	-	SYM
admet-441	263	22	221	221	NUM
admet-441	263	23	.	.	PUNCT
admet-441	264	1	[	[	X
admet-441	264	2	41	41	NUM
admet-441	264	3	]	]	X
admet-441	264	4	p.a	p.a	PROPN
admet-441	264	5	.	.	PROPN
admet-441	264	6	dawson	dawson	PROPN
admet-441	264	7	,	,	PUNCT
admet-441	264	8	t.	t.	PROPN
admet-441	264	9	lan	lan	PROPN
admet-441	264	10	,	,	PUNCT
admet-441	264	11	a.	a.	PROPN
admet-441	264	12	rao	rao	PROPN
admet-441	264	13	.	.	PUNCT
admet-441	265	1	bile	bile	NOUN
admet-441	265	2	acid	acid	NOUN
admet-441	265	3	transporters	transporter	NOUN
admet-441	265	4	.	.	PUNCT
admet-441	266	1	j	j	PROPN
admet-441	266	2	lipid	lipid	PROPN
admet-441	266	3	res	re	VERB
admet-441	266	4	50	50	NUM
admet-441	266	5	(	(	PUNCT
admet-441	266	6	2009	2009	NUM
admet-441	266	7	)	)	PUNCT
admet-441	266	8	2340	2340	NUM
admet-441	266	9	-	-	SYM
admet-441	266	10	2357	2357	NUM
admet-441	266	11	.	.	PUNCT
admet-441	267	1	[	[	X
admet-441	267	2	42	42	NUM
admet-441	267	3	]	]	X
admet-441	267	4	r.e	r.e	PROPN
admet-441	267	5	.	.	PROPN
admet-441	267	6	morgan	morgan	PROPN
admet-441	267	7	,	,	PUNCT
admet-441	267	8	m.	m.	NOUN
admet-441	267	9	trauner	trauner	NOUN
admet-441	267	10	,	,	PUNCT
admet-441	267	11	c.j	c.j	PROPN
admet-441	267	12	.	.	PROPN
admet-441	267	13	van	van	PROPN
admet-441	267	14	staden	staden	PROPN
admet-441	267	15	,	,	PUNCT
admet-441	267	16	p.h	p.h	PROPN
admet-441	267	17	.	.	PROPN
admet-441	267	18	lee	lee	PROPN
admet-441	267	19	,	,	PUNCT
admet-441	267	20	b.	b.	PROPN
admet-441	267	21	ramachandran	ramachandran	PROPN
admet-441	267	22	,	,	PUNCT
admet-441	267	23	m.	m.	PROPN
admet-441	267	24	eschenberg	eschenberg	PROPN
admet-441	267	25	,	,	PUNCT
admet-441	267	26	c.a	c.a	PROPN
admet-441	267	27	.	.	PROPN
admet-441	267	28	afshari	afshari	PROPN
admet-441	267	29	,	,	PUNCT
admet-441	267	30	c.w	c.w	PROPN
admet-441	267	31	.	.	PROPN
admet-441	267	32	qualls	qualls	PROPN
admet-441	267	33	,	,	PUNCT
admet-441	267	34	jr	jr	PROPN
admet-441	267	35	.	.	PROPN
admet-441	267	36	,	,	PUNCT
admet-441	267	37	r.	r.	PROPN
admet-441	267	38	lightfoot	lightfoot	PROPN
admet-441	267	39	-	-	PUNCT
admet-441	267	40	dunn	dunn	PROPN
admet-441	267	41	,	,	PUNCT
admet-441	267	42	h.k	h.k	PROPN
admet-441	267	43	.	.	PROPN
admet-441	267	44	hamadeh	hamadeh	PROPN
admet-441	267	45	.	.	PUNCT
admet-441	268	1	interference	interference	VERB
admet-441	268	2	with	with	ADP
admet-441	268	3	bile	bile	NOUN
admet-441	268	4	salt	salt	NOUN
admet-441	268	5	export	export	NOUN
admet-441	268	6	pump	pump	NOUN
admet-441	268	7	function	function	NOUN
admet-441	268	8	is	be	AUX
admet-441	268	9	a	a	DET
admet-441	268	10	susceptibility	susceptibility	NOUN
admet-441	268	11	factor	factor	NOUN
admet-441	268	12	for	for	ADP
admet-441	268	13	human	human	ADJ
admet-441	268	14	liver	liver	NOUN
admet-441	268	15	injury	injury	NOUN
admet-441	268	16	in	in	ADP
admet-441	268	17	drug	drug	NOUN
admet-441	268	18	development	development	NOUN
admet-441	268	19	.	.	PUNCT
admet-441	269	1	toxicol	toxicol	PROPN
admet-441	269	2	sci	sci	PROPN
admet-441	269	3	118	118	NUM
admet-441	269	4	(	(	PUNCT
admet-441	269	5	2010	2010	NUM
admet-441	269	6	)	)	PUNCT
admet-441	269	7	485	485	NUM
admet-441	269	8	-	-	SYM
admet-441	269	9	500	500	NUM
admet-441	269	10	.	.	PUNCT
admet-441	270	1	[	[	X
admet-441	270	2	43	43	NUM
admet-441	270	3	]	]	X
admet-441	270	4	s.	s.	PROPN
admet-441	270	5	dawson	dawson	PROPN
admet-441	270	6	,	,	PUNCT
admet-441	270	7	s.	s.	PROPN
admet-441	270	8	stahl	stahl	PROPN
admet-441	270	9	,	,	PUNCT
admet-441	270	10	n.	n.	PROPN
admet-441	270	11	paul	paul	PROPN
admet-441	270	12	,	,	PUNCT
admet-441	270	13	j.	j.	PROPN
admet-441	270	14	barber	barber	PROPN
admet-441	270	15	,	,	PUNCT
admet-441	270	16	j.g	j.g	PROPN
admet-441	270	17	.	.	PROPN
admet-441	270	18	kenna	kenna	PROPN
admet-441	270	19	.	.	PUNCT
admet-441	271	1	in	in	ADP
admet-441	271	2	vitro	vitro	X
admet-441	271	3	inhibition	inhibition	NOUN
admet-441	271	4	of	of	ADP
admet-441	271	5	the	the	DET
admet-441	271	6	bile	bile	NOUN
admet-441	271	7	salt	salt	NOUN
admet-441	271	8	export	export	NOUN
admet-441	271	9	pump	pump	NOUN
admet-441	271	10	correlates	correlate	VERB
admet-441	271	11	with	with	ADP
admet-441	271	12	risk	risk	NOUN
admet-441	271	13	of	of	ADP
admet-441	271	14	cholestatic	cholestatic	ADJ
admet-441	271	15	drug	drug	NOUN
admet-441	271	16	-	-	PUNCT
admet-441	271	17	induced	induce	VERB
admet-441	271	18	liver	liver	NOUN
admet-441	271	19	injury	injury	NOUN
admet-441	271	20	in	in	ADP
admet-441	271	21	humans	human	NOUN
admet-441	271	22	.	.	PUNCT
admet-441	272	1	drug	drug	NOUN
admet-441	272	2	metab	metab	PROPN
admet-441	272	3	dispos	dispos	PROPN
admet-441	272	4	40	40	NUM
admet-441	272	5	(	(	PUNCT
admet-441	272	6	2012	2012	NUM
admet-441	272	7	)	)	PUNCT
admet-441	272	8	130	130	NUM
admet-441	272	9	-	-	SYM
admet-441	272	10	138	138	NUM
admet-441	272	11	.	.	PUNCT
admet-441	273	1	[	[	X
admet-441	273	2	44	44	NUM
admet-441	273	3	]	]	PUNCT
admet-441	273	4	k.	k.	PROPN
admet-441	273	5	kock	kock	PROPN
admet-441	273	6	,	,	PUNCT
admet-441	273	7	b.c	b.c	PROPN
admet-441	273	8	.	.	PROPN
admet-441	273	9	ferslew	ferslew	PROPN
admet-441	273	10	,	,	PUNCT
admet-441	273	11	i.	i.	PROPN
admet-441	273	12	netterberg	netterberg	PROPN
admet-441	273	13	,	,	PUNCT
admet-441	273	14	k.	k.	PROPN
admet-441	273	15	yang	yang	PROPN
admet-441	273	16	,	,	PUNCT
admet-441	273	17	t.j	t.j	PROPN
admet-441	273	18	.	.	PROPN
admet-441	273	19	urban	urban	PROPN
admet-441	273	20	,	,	PUNCT
admet-441	273	21	p.w	p.w	PROPN
admet-441	273	22	.	.	PROPN
admet-441	273	23	swaan	swaan	PROPN
admet-441	273	24	,	,	PUNCT
admet-441	273	25	p.w	p.w	PROPN
admet-441	273	26	.	.	PROPN
admet-441	273	27	stewart	stewart	PROPN
admet-441	273	28	,	,	PUNCT
admet-441	273	29	k.l	k.l	PROPN
admet-441	273	30	.	.	PROPN
admet-441	273	31	brouwer	brouwer	PROPN
admet-441	273	32	.	.	PUNCT
admet-441	274	1	risk	risk	NOUN
admet-441	274	2	factors	factor	NOUN
admet-441	274	3	for	for	ADP
admet-441	274	4	development	development	NOUN
admet-441	274	5	of	of	ADP
admet-441	274	6	cholestatic	cholestatic	ADJ
admet-441	274	7	drug	drug	NOUN
admet-441	274	8	-	-	PUNCT
admet-441	274	9	induced	induce	VERB
admet-441	274	10	liver	liver	NOUN
admet-441	274	11	injury	injury	NOUN
admet-441	274	12	:	:	PUNCT
admet-441	274	13	inhibition	inhibition	NOUN
admet-441	274	14	of	of	ADP
admet-441	274	15	hepatic	hepatic	ADJ
admet-441	274	16	basolateral	basolateral	ADJ
admet-441	274	17	bile	bile	NOUN
admet-441	274	18	acid	acid	NOUN
admet-441	274	19	transporters	transporter	NOUN
admet-441	274	20	multidrug	multidrug	VERB
admet-441	274	21	resistance	resistance	NOUN
admet-441	274	22	-	-	PUNCT
admet-441	274	23	associated	associate	VERB
admet-441	274	24	proteins	protein	NOUN
admet-441	274	25	3	3	NUM
admet-441	274	26	and	and	CCONJ
admet-441	274	27	4	4	NUM
admet-441	274	28	.	.	NOUN
admet-441	274	29	drug	drug	NOUN
admet-441	274	30	metab	metab	PROPN
admet-441	274	31	dispos	dispos	PROPN
admet-441	274	32	42	42	NUM
admet-441	274	33	(	(	PUNCT
admet-441	274	34	2014	2014	NUM
admet-441	274	35	)	)	PUNCT
admet-441	274	36	665	665	NUM
admet-441	274	37	-	-	SYM
admet-441	274	38	674	674	NUM
admet-441	274	39	.	.	PUNCT
admet-441	275	1	[	[	X
admet-441	275	2	45	45	NUM
admet-441	275	3	]	]	X
admet-441	275	4	j.m	j.m	PROPN
admet-441	275	5	.	.	PROPN
admet-441	275	6	pedersen	pedersen	PROPN
admet-441	275	7	,	,	PUNCT
admet-441	275	8	p.	p.	PROPN
admet-441	275	9	matsson	matsson	PROPN
admet-441	275	10	,	,	PUNCT
admet-441	275	11	c.a	c.a	PROPN
admet-441	275	12	.	.	PROPN
admet-441	275	13	bergstrom	bergstrom	PROPN
admet-441	275	14	,	,	PUNCT
admet-441	275	15	j.	j.	PROPN
admet-441	275	16	hoogstraate	hoogstraate	PROPN
admet-441	275	17	,	,	PUNCT
admet-441	275	18	a.	a.	PROPN
admet-441	275	19	noren	noren	PROPN
admet-441	275	20	,	,	PUNCT
admet-441	275	21	e.l	e.l	PROPN
admet-441	275	22	.	.	PROPN
admet-441	275	23	lecluyse	lecluyse	PROPN
admet-441	275	24	,	,	PUNCT
admet-441	275	25	p.	p.	PROPN
admet-441	275	26	artursson	artursson	PROPN
admet-441	275	27	.	.	PUNCT
admet-441	276	1	early	early	ADJ
admet-441	276	2	identification	identification	NOUN
admet-441	276	3	of	of	ADP
admet-441	276	4	clinically	clinically	ADV
admet-441	276	5	relevant	relevant	ADJ
admet-441	276	6	drug	drug	NOUN
admet-441	276	7	interactions	interaction	NOUN
admet-441	276	8	with	with	ADP
admet-441	276	9	the	the	DET
admet-441	276	10	human	human	ADJ
admet-441	276	11	bile	bile	NOUN
admet-441	276	12	salt	salt	NOUN
admet-441	276	13	export	export	NOUN
admet-441	276	14	pump	pump	NOUN
admet-441	276	15	(	(	PUNCT
admet-441	276	16	bsep	bsep	NOUN
admet-441	276	17	/	/	SYM
admet-441	276	18	abcb11	abcb11	NOUN
admet-441	276	19	)	)	PUNCT
admet-441	276	20	.	.	PUNCT
admet-441	277	1	toxicol	toxicol	PROPN
admet-441	277	2	sci	sci	PROPN
admet-441	277	3	136	136	NUM
admet-441	277	4	(	(	PUNCT
admet-441	277	5	2013	2013	NUM
admet-441	277	6	)	)	PUNCT
admet-441	277	7	328	328	NUM
admet-441	277	8	-	-	SYM
admet-441	277	9	343	343	NUM
admet-441	277	10	.	.	PUNCT
admet-441	278	1	[	[	X
admet-441	278	2	46	46	NUM
admet-441	278	3	]	]	PUNCT
admet-441	278	4	k.	k.	PROPN
admet-441	278	5	yang	yang	PROPN
admet-441	278	6	,	,	PUNCT
admet-441	278	7	k.	k.	PROPN
admet-441	278	8	kock	kock	PROPN
admet-441	278	9	,	,	PUNCT
admet-441	278	10	a.	a.	NOUN
admet-441	278	11	sedykh	sedykh	PROPN
admet-441	278	12	,	,	PUNCT
admet-441	278	13	a.	a.	NOUN
admet-441	278	14	tropsha	tropsha	PROPN
admet-441	278	15	,	,	PUNCT
admet-441	278	16	k.l	k.l	PROPN
admet-441	278	17	.	.	PROPN
admet-441	278	18	brouwer	brouwer	PROPN
admet-441	278	19	.	.	PUNCT
admet-441	279	1	an	an	DET
admet-441	279	2	updated	update	VERB
admet-441	279	3	review	review	NOUN
admet-441	279	4	on	on	ADP
admet-441	279	5	drug	drug	NOUN
admet-441	279	6	-	-	PUNCT
admet-441	279	7	induced	induce	VERB
admet-441	279	8	cholestasis	cholestasis	NOUN
admet-441	279	9	:	:	PUNCT
admet-441	279	10	mechanisms	mechanism	NOUN
admet-441	279	11	and	and	CCONJ
admet-441	279	12	investigation	investigation	NOUN
admet-441	279	13	of	of	ADP
admet-441	279	14	physicochemical	physicochemical	ADJ
admet-441	279	15	properties	property	NOUN
admet-441	279	16	and	and	CCONJ
admet-441	279	17	pharmacokinetic	pharmacokinetic	ADJ
admet-441	279	18	parameters	parameter	NOUN
admet-441	279	19	.	.	PUNCT
admet-441	280	1	j	j	PROPN
admet-441	280	2	pharm	pharm	PROPN
admet-441	280	3	sci	sci	PROPN
admet-441	280	4	102	102	NUM
admet-441	280	5	(	(	PUNCT
admet-441	280	6	2013	2013	NUM
admet-441	280	7	)	)	PUNCT
admet-441	280	8	3037	3037	NUM
admet-441	280	9	-	-	SYM
admet-441	280	10	3057	3057	NUM
admet-441	280	11	.	.	PUNCT
admet-441	281	1	pankajini	pankajini	PROPN
admet-441	281	2	mallick	mallick	PROPN
admet-441	281	3	admet	admet	PROPN
admet-441	281	4	&	&	CCONJ
admet-441	281	5	dmpk	dmpk	PROPN
admet-441	281	6	5(4	5(4	NOUN
admet-441	281	7	)	)	PUNCT
admet-441	281	8	(	(	PUNCT
admet-441	281	9	2017	2017	NUM
admet-441	281	10	)	)	PUNCT
admet-441	281	11	201	201	NUM
admet-441	281	12	-	-	SYM
admet-441	281	13	211	211	NUM
admet-441	281	14	210	210	NUM
admet-441	281	15	[	[	X
admet-441	281	16	47	47	NUM
admet-441	281	17	]	]	X
admet-441	281	18	a.d	a.d	PROPN
admet-441	281	19	.	.	PROPN
admet-441	281	20	rodrigues	rodrigues	PROPN
admet-441	281	21	,	,	PUNCT
admet-441	281	22	y.	y.	PROPN
admet-441	281	23	lai	lai	PROPN
admet-441	281	24	,	,	PUNCT
admet-441	281	25	m.e	m.e	PROPN
admet-441	281	26	.	.	PROPN
admet-441	281	27	cvijic	cvijic	PROPN
admet-441	281	28	,	,	PUNCT
admet-441	281	29	l.l	l.l	PROPN
admet-441	281	30	.	.	PROPN
admet-441	281	31	elkin	elkin	PROPN
admet-441	281	32	,	,	PUNCT
admet-441	281	33	t.	t.	NOUN
admet-441	281	34	zvyaga	zvyaga	NOUN
admet-441	281	35	,	,	PUNCT
admet-441	281	36	m.g	m.g	PROPN
admet-441	281	37	.	.	PROPN
admet-441	281	38	soars	soars	PROPN
admet-441	281	39	.	.	PUNCT
admet-441	282	1	drug	drug	NOUN
admet-441	282	2	-	-	PUNCT
admet-441	282	3	induced	induce	VERB
admet-441	282	4	perturbations	perturbation	NOUN
admet-441	282	5	of	of	ADP
admet-441	282	6	the	the	DET
admet-441	282	7	bile	bile	NOUN
admet-441	282	8	acid	acid	NOUN
admet-441	282	9	pool	pool	NOUN
admet-441	282	10	,	,	PUNCT
admet-441	282	11	cholestasis	cholestasis	NOUN
admet-441	282	12	,	,	PUNCT
admet-441	282	13	and	and	CCONJ
admet-441	282	14	hepatotoxicity	hepatotoxicity	NOUN
admet-441	282	15	:	:	PUNCT
admet-441	282	16	mechanistic	mechanistic	ADJ
admet-441	282	17	considerations	consideration	NOUN
admet-441	282	18	beyond	beyond	ADP
admet-441	282	19	the	the	DET
admet-441	282	20	direct	direct	ADJ
admet-441	282	21	inhibition	inhibition	NOUN
admet-441	282	22	of	of	ADP
admet-441	282	23	the	the	DET
admet-441	282	24	bile	bile	NOUN
admet-441	282	25	salt	salt	NOUN
admet-441	282	26	export	export	NOUN
admet-441	282	27	pump	pump	NOUN
admet-441	282	28	.	.	PUNCT
admet-441	283	1	drug	drug	NOUN
admet-441	283	2	metab	metab	PROPN
admet-441	283	3	dispos	dispos	PROPN
admet-441	283	4	42	42	NUM
admet-441	283	5	(	(	PUNCT
admet-441	283	6	2014	2014	NUM
admet-441	283	7	)	)	PUNCT
admet-441	283	8	566	566	NUM
admet-441	283	9	-	-	SYM
admet-441	283	10	574	574	NUM
admet-441	283	11	.	.	PUNCT
admet-441	284	1	[	[	X
admet-441	284	2	48	48	NUM
admet-441	284	3	]	]	X
admet-441	284	4	p.b	p.b	PROPN
admet-441	284	5	.	.	PROPN
admet-441	284	6	watkins	watkins	PROPN
admet-441	284	7	.	.	PUNCT
admet-441	285	1	idiosyncratic	idiosyncratic	ADJ
admet-441	285	2	liver	liver	NOUN
admet-441	285	3	injury	injury	NOUN
admet-441	285	4	:	:	PUNCT
admet-441	285	5	challenges	challenge	NOUN
admet-441	285	6	and	and	CCONJ
admet-441	285	7	approaches	approach	NOUN
admet-441	285	8	.	.	PUNCT
admet-441	286	1	toxicol	toxicol	PROPN
admet-441	286	2	pathol	pathol	VERB
admet-441	286	3	33	33	NUM
admet-441	286	4	(	(	PUNCT
admet-441	286	5	2005	2005	NUM
admet-441	286	6	)	)	PUNCT
admet-441	286	7	1	1	NUM
admet-441	286	8	-	-	SYM
admet-441	286	9	5	5	NUM
admet-441	286	10	.	.	PUNCT
admet-441	287	1	[	[	X
admet-441	287	2	49	49	NUM
admet-441	287	3	]	]	X
admet-441	287	4	e.m	e.m	PROPN
admet-441	287	5	.	.	PROPN
admet-441	287	6	leslie	leslie	PROPN
admet-441	287	7	,	,	PUNCT
admet-441	287	8	p.b	p.b	PROPN
admet-441	287	9	.	.	PROPN
admet-441	287	10	watkins	watkins	PROPN
admet-441	287	11	,	,	PUNCT
admet-441	287	12	r.b	r.b	PROPN
admet-441	287	13	.	.	PROPN
admet-441	287	14	kim	kim	PROPN
admet-441	287	15	,	,	PUNCT
admet-441	287	16	k.l	k.l	PROPN
admet-441	287	17	.	.	PROPN
admet-441	287	18	brouwer	brouwer	PROPN
admet-441	287	19	.	.	PUNCT
admet-441	288	1	differential	differential	ADJ
admet-441	288	2	inhibition	inhibition	NOUN
admet-441	288	3	of	of	ADP
admet-441	288	4	rat	rat	NOUN
admet-441	288	5	and	and	CCONJ
admet-441	288	6	human	human	ADJ
admet-441	288	7	na+dependent	na+dependent	ADJ
admet-441	288	8	taurocholate	taurocholate	NOUN
admet-441	288	9	cotransporting	cotransporte	VERB
admet-441	288	10	polypeptide	polypeptide	ADJ
admet-441	288	11	(	(	PUNCT
admet-441	288	12	ntcp	ntcp	PROPN
admet-441	288	13	/	/	SYM
admet-441	288	14	slc10a1)by	slc10a1)by	PROPN
admet-441	288	15	bosentan	bosentan	VERB
admet-441	288	16	:	:	PUNCT
admet-441	288	17	a	a	DET
admet-441	288	18	mechanism	mechanism	NOUN
admet-441	288	19	for	for	ADP
admet-441	288	20	species	specie	NOUN
admet-441	288	21	differences	difference	NOUN
admet-441	288	22	in	in	ADP
admet-441	288	23	hepatotoxicity	hepatotoxicity	NOUN
admet-441	288	24	.	.	PUNCT
admet-441	289	1	j	j	PROPN
admet-441	289	2	pharmacol	pharmacol	PROPN
admet-441	289	3	exp	exp	NOUN
admet-441	289	4	ther	ther	ADV
admet-441	289	5	321	321	NUM
admet-441	289	6	(	(	PUNCT
admet-441	289	7	2007	2007	NUM
admet-441	289	8	)	)	PUNCT
admet-441	289	9	1170	1170	NUM
admet-441	289	10	-	-	SYM
admet-441	289	11	1178	1178	NUM
admet-441	289	12	.	.	PUNCT
admet-441	290	1	[	[	X
admet-441	290	2	50	50	NUM
admet-441	290	3	]	]	X
admet-441	290	4	j.l	j.l	PROPN
admet-441	290	5	.	.	PROPN
admet-441	290	6	woodhead	woodhead	PROPN
admet-441	290	7	,	,	PUNCT
admet-441	290	8	k.	k.	PROPN
admet-441	290	9	yang	yang	PROPN
admet-441	290	10	,	,	PUNCT
admet-441	290	11	s.q	s.q	PROPN
admet-441	290	12	.	.	PROPN
admet-441	290	13	siler	siler	PROPN
admet-441	290	14	,	,	PUNCT
admet-441	290	15	p.b	p.b	PROPN
admet-441	290	16	.	.	PROPN
admet-441	290	17	watkins	watkins	PROPN
admet-441	290	18	,	,	PUNCT
admet-441	290	19	k.l	k.l	PROPN
admet-441	290	20	.	.	PROPN
admet-441	290	21	brouwer	brouwer	PROPN
admet-441	290	22	,	,	PUNCT
admet-441	290	23	h.a	h.a	PROPN
admet-441	290	24	.	.	PROPN
admet-441	290	25	barton	barton	PROPN
admet-441	290	26	,	,	PUNCT
admet-441	290	27	b.a	b.a	PROPN
admet-441	290	28	.	.	PROPN
admet-441	290	29	howell	howell	PROPN
admet-441	290	30	.	.	PUNCT
admet-441	291	1	exploring	explore	VERB
admet-441	291	2	bsep	bsep	NOUN
admet-441	291	3	inhibition	inhibition	NOUN
admet-441	291	4	-	-	PUNCT
admet-441	291	5	mediated	mediate	VERB
admet-441	291	6	toxicity	toxicity	NOUN
admet-441	291	7	with	with	ADP
admet-441	291	8	a	a	DET
admet-441	291	9	mechanistic	mechanistic	ADJ
admet-441	291	10	model	model	NOUN
admet-441	291	11	of	of	ADP
admet-441	291	12	drug	drug	NOUN
admet-441	291	13	-	-	PUNCT
admet-441	291	14	induced	induce	VERB
admet-441	291	15	liver	liver	NOUN
admet-441	291	16	injury	injury	NOUN
admet-441	291	17	.	.	PUNCT
admet-441	292	1	front	front	ADJ
admet-441	292	2	pharmacol	pharmacol	PROPN
admet-441	292	3	5	5	NUM
admet-441	292	4	(	(	PUNCT
admet-441	292	5	2014	2014	NUM
admet-441	292	6	)	)	PUNCT
admet-441	292	7	240	240	NUM
admet-441	292	8	.	.	PUNCT
admet-441	293	1	[	[	X
admet-441	293	2	51	51	NUM
admet-441	293	3	]	]	PUNCT
admet-441	293	4	k.	k.	PROPN
admet-441	293	5	yang	yang	PROPN
admet-441	293	6	,	,	PUNCT
admet-441	293	7	j.l	j.l	PROPN
admet-441	293	8	.	.	PROPN
admet-441	293	9	woodhead	woodhead	PROPN
admet-441	293	10	,	,	PUNCT
admet-441	293	11	p.b	p.b	PROPN
admet-441	293	12	.	.	PROPN
admet-441	293	13	watkins	watkins	PROPN
admet-441	293	14	,	,	PUNCT
admet-441	293	15	b.a	b.a	PROPN
admet-441	293	16	.	.	PROPN
admet-441	293	17	howell	howell	PROPN
admet-441	293	18	,	,	PUNCT
admet-441	293	19	k.l	k.l	PROPN
admet-441	293	20	.	.	PROPN
admet-441	293	21	brouwer	brouwer	PROPN
admet-441	293	22	.	.	PUNCT
admet-441	294	1	systems	system	NOUN
admet-441	294	2	pharmacology	pharmacology	NOUN
admet-441	294	3	modeling	modeling	NOUN
admet-441	294	4	predicts	predict	NOUN
admet-441	294	5	delayed	delay	VERB
admet-441	294	6	presentation	presentation	NOUN
admet-441	294	7	and	and	CCONJ
admet-441	294	8	species	species	NOUN
admet-441	294	9	differences	difference	NOUN
admet-441	294	10	in	in	ADP
admet-441	294	11	bile	bile	NOUN
admet-441	294	12	acid	acid	NOUN
admet-441	294	13	-	-	PUNCT
admet-441	294	14	mediated	mediate	VERB
admet-441	294	15	troglitazone	troglitazone	NOUN
admet-441	294	16	hepatotoxicity	hepatotoxicity	NOUN
admet-441	294	17	.	.	PUNCT
admet-441	295	1	clin	clin	PROPN
admet-441	295	2	pharmacol	pharmacol	PROPN
admet-441	295	3	ther	ther	ADV
admet-441	295	4	96	96	NUM
admet-441	295	5	(	(	PUNCT
admet-441	295	6	2014	2014	NUM
admet-441	295	7	)	)	PUNCT
admet-441	295	8	589	589	NUM
admet-441	295	9	-	-	SYM
admet-441	295	10	598	598	NUM
admet-441	295	11	.	.	PUNCT
admet-441	296	1	[	[	X
admet-441	296	2	52	52	NUM
admet-441	296	3	]	]	PUNCT
admet-441	296	4	x.	x.	PROPN
admet-441	296	5	cao	cao	PROPN
admet-441	296	6	,	,	PUNCT
admet-441	296	7	l.x	l.x	PROPN
admet-441	296	8	.	.	PROPN
admet-441	296	9	yu	yu	PROPN
admet-441	296	10	,	,	PUNCT
admet-441	296	11	c.	c.	PROPN
admet-441	296	12	barbaciru	barbaciru	PROPN
admet-441	296	13	,	,	PUNCT
admet-441	296	14	c.p	c.p	PROPN
admet-441	296	15	.	.	PROPN
admet-441	296	16	landowski	landowski	PROPN
admet-441	296	17	,	,	PUNCT
admet-441	296	18	h.c	h.c	PROPN
admet-441	296	19	.	.	PROPN
admet-441	296	20	shin	shin	PROPN
admet-441	296	21	,	,	PUNCT
admet-441	296	22	s.	s.	PROPN
admet-441	296	23	gibbs	gibbs	PROPN
admet-441	296	24	,	,	PUNCT
admet-441	296	25	h.a	h.a	PROPN
admet-441	296	26	.	.	PROPN
admet-441	296	27	miller	miller	PROPN
admet-441	296	28	,	,	PUNCT
admet-441	296	29	g.l	g.l	PROPN
admet-441	296	30	.	.	PROPN
admet-441	296	31	amidon	amidon	PROPN
admet-441	296	32	,	,	PUNCT
admet-441	296	33	d.	d.	PROPN
admet-441	296	34	sun	sun	PROPN
admet-441	296	35	.	.	PUNCT
admet-441	297	1	permeability	permeability	NOUN
admet-441	297	2	dominates	dominate	VERB
admet-441	297	3	in	in	ADP
admet-441	297	4	vivo	vivo	ADJ
admet-441	297	5	intestinal	intestinal	ADJ
admet-441	297	6	absorption	absorption	NOUN
admet-441	297	7	of	of	ADP
admet-441	297	8	p	p	NOUN
admet-441	297	9	-	-	PUNCT
admet-441	297	10	gp	gp	NOUN
admet-441	297	11	substrate	substrate	NOUN
admet-441	297	12	with	with	ADP
admet-441	297	13	high	high	ADJ
admet-441	297	14	solubility	solubility	NOUN
admet-441	297	15	and	and	CCONJ
admet-441	297	16	high	high	ADJ
admet-441	297	17	permeability	permeability	NOUN
admet-441	297	18	.	.	PUNCT
admet-441	298	1	mol	mol	ADP
admet-441	298	2	pharm	pharm	NOUN
admet-441	298	3	2	2	NUM
admet-441	298	4	(	(	PUNCT
admet-441	298	5	2005	2005	NUM
admet-441	298	6	)	)	PUNCT
admet-441	298	7	329	329	NUM
admet-441	298	8	-	-	SYM
admet-441	298	9	340	340	NUM
admet-441	298	10	.	.	PUNCT
admet-441	299	1	[	[	X
admet-441	299	2	53	53	NUM
admet-441	299	3	]	]	X
admet-441	299	4	c.l	c.l	PROPN
admet-441	299	5	.	.	PROPN
admet-441	299	6	cummins	cummins	PROPN
admet-441	299	7	,	,	PUNCT
admet-441	299	8	l.	l.	PROPN
admet-441	299	9	salphati	salphati	PROPN
admet-441	299	10	,	,	PUNCT
admet-441	299	11	m.j	m.j	PROPN
admet-441	299	12	.	.	PROPN
admet-441	299	13	reid	reid	PROPN
admet-441	299	14	,	,	PUNCT
admet-441	299	15	l.z	l.z	PROPN
admet-441	299	16	.	.	PROPN
admet-441	299	17	benet	benet	PROPN
admet-441	299	18	.	.	PUNCT
admet-441	300	1	in	in	ADP
admet-441	300	2	vivo	vivo	ADJ
admet-441	300	3	modulation	modulation	NOUN
admet-441	300	4	of	of	ADP
admet-441	300	5	intestinal	intestinal	ADJ
admet-441	300	6	cyp3a	cyp3a	NOUN
admet-441	300	7	metabolism	metabolism	NOUN
admet-441	300	8	by	by	ADP
admet-441	300	9	p	p	NOUN
admet-441	300	10	-	-	PUNCT
admet-441	300	11	glycoprotein	glycoprotein	NOUN
admet-441	300	12	:	:	PUNCT
admet-441	300	13	studies	study	NOUN
admet-441	300	14	using	use	VERB
admet-441	300	15	the	the	DET
admet-441	300	16	rat	rat	NOUN
admet-441	300	17	single	single	ADJ
admet-441	300	18	-	-	PUNCT
admet-441	300	19	pass	pass	ADJ
admet-441	300	20	intestinal	intestinal	ADJ
admet-441	300	21	perfusion	perfusion	NOUN
admet-441	300	22	model	model	NOUN
admet-441	300	23	.	.	PUNCT
admet-441	301	1	j	j	PROPN
admet-441	301	2	pharmacol	pharmacol	PROPN
admet-441	301	3	exp	exp	NOUN
admet-441	301	4	ther	ther	ADV
admet-441	301	5	305	305	NUM
admet-441	301	6	(	(	PUNCT
admet-441	301	7	2003	2003	NUM
admet-441	301	8	)	)	PUNCT
admet-441	301	9	306	306	NUM
admet-441	301	10	-	-	SYM
admet-441	301	11	314	314	NUM
admet-441	301	12	.	.	PUNCT
admet-441	302	1	[	[	X
admet-441	302	2	54	54	NUM
admet-441	302	3	]	]	X
admet-441	302	4	k.s	k.s	PROPN
admet-441	302	5	.	.	PROPN
admet-441	302	6	pang	pang	NOUN
admet-441	302	7	.	.	PUNCT
admet-441	303	1	modeling	modeling	NOUN
admet-441	303	2	of	of	ADP
admet-441	303	3	intestinal	intestinal	ADJ
admet-441	303	4	drug	drug	NOUN
admet-441	303	5	absorption	absorption	NOUN
admet-441	303	6	:	:	PUNCT
admet-441	303	7	roles	role	NOUN
admet-441	303	8	of	of	ADP
admet-441	303	9	transporters	transporter	NOUN
admet-441	303	10	and	and	CCONJ
admet-441	303	11	metabolic	metabolic	NOUN
admet-441	303	12	enzymes	enzyme	NOUN
admet-441	303	13	(	(	PUNCT
admet-441	303	14	for	for	ADP
admet-441	303	15	the	the	DET
admet-441	303	16	gillette	gillette	PROPN
admet-441	303	17	review	review	PROPN
admet-441	303	18	series	series	PROPN
admet-441	303	19	)	)	PUNCT
admet-441	303	20	.	.	PUNCT
admet-441	304	1	drug	drug	NOUN
admet-441	304	2	metab	metab	PROPN
admet-441	304	3	dispos	dispos	PROPN
admet-441	304	4	31	31	NUM
admet-441	304	5	(	(	PUNCT
admet-441	304	6	2003	2003	NUM
admet-441	304	7	)	)	PUNCT
admet-441	304	8	1507	1507	NUM
admet-441	304	9	-	-	SYM
admet-441	304	10	1519	1519	NUM
admet-441	304	11	.	.	PUNCT
admet-441	305	1	[	[	X
admet-441	305	2	55	55	NUM
admet-441	305	3	]	]	PUNCT
admet-441	305	4	m.	m.	NOUN
admet-441	305	5	jamei	jamei	PROPN
admet-441	305	6	,	,	PUNCT
admet-441	305	7	d.	d.	PROPN
admet-441	305	8	turner	turner	PROPN
admet-441	305	9	,	,	PUNCT
admet-441	305	10	j.	j.	PROPN
admet-441	305	11	yang	yang	PROPN
admet-441	305	12	,	,	PUNCT
admet-441	305	13	s.	s.	PROPN
admet-441	305	14	neuhoff	neuhoff	PROPN
admet-441	305	15	,	,	PUNCT
admet-441	305	16	s.	s.	PROPN
admet-441	305	17	polak	polak	PROPN
admet-441	305	18	,	,	PUNCT
admet-441	305	19	a.	a.	PROPN
admet-441	305	20	rostami	rostami	PROPN
admet-441	305	21	-	-	PUNCT
admet-441	305	22	hodjegan	hodjegan	PROPN
admet-441	305	23	,	,	PUNCT
admet-441	305	24	g.	g.	PROPN
admet-441	305	25	tucker	tucker	PROPN
admet-441	305	26	.	.	PUNCT
admet-441	306	1	population	population	NOUN
admet-441	306	2	-	-	PUNCT
admet-441	306	3	based	base	VERB
admet-441	306	4	mechanistic	mechanistic	ADJ
admet-441	306	5	prediction	prediction	NOUN
admet-441	306	6	of	of	ADP
admet-441	306	7	oral	oral	ADJ
admet-441	306	8	drug	drug	NOUN
admet-441	306	9	absorption	absorption	NOUN
admet-441	306	10	.	.	PUNCT
admet-441	307	1	aaps	aap	NOUN
admet-441	307	2	j	j	PROPN
admet-441	307	3	11	11	NUM
admet-441	307	4	(	(	PUNCT
admet-441	307	5	2009	2009	NUM
admet-441	307	6	)	)	PUNCT
admet-441	307	7	225	225	NUM
admet-441	307	8	-	-	SYM
admet-441	307	9	237	237	NUM
admet-441	307	10	.	.	PUNCT
admet-441	308	1	[	[	X
admet-441	308	2	56	56	NUM
admet-441	308	3	]	]	X
admet-441	308	4	a.s	a.s	PROPN
admet-441	308	5	.	.	PROPN
admet-441	308	6	darwich	darwich	PROPN
admet-441	308	7	,	,	PUNCT
admet-441	308	8	s.	s.	PROPN
admet-441	308	9	neuhoff	neuhoff	PROPN
admet-441	308	10	,	,	PUNCT
admet-441	308	11	m.	m.	PROPN
admet-441	308	12	jamei	jamei	PROPN
admet-441	308	13	,	,	PUNCT
admet-441	308	14	a.	a.	PROPN
admet-441	308	15	rostami	rostami	PROPN
admet-441	308	16	-	-	PUNCT
admet-441	308	17	hodjegan	hodjegan	PROPN
admet-441	308	18	.	.	PUNCT
admet-441	308	19	interplay	interplay	NOUN
admet-441	308	20	of	of	ADP
admet-441	308	21	metabolism	metabolism	NOUN
admet-441	308	22	and	and	CCONJ
admet-441	308	23	transport	transport	NOUN
admet-441	308	24	in	in	ADP
admet-441	308	25	determining	determine	VERB
admet-441	308	26	oral	oral	ADJ
admet-441	308	27	drug	drug	NOUN
admet-441	308	28	absorption	absorption	NOUN
admet-441	308	29	and	and	CCONJ
admet-441	308	30	gut	gut	VERB
admet-441	308	31	wall	wall	NOUN
admet-441	308	32	metabolism	metabolism	NOUN
admet-441	308	33	:	:	PUNCT
admet-441	308	34	a	a	DET
admet-441	308	35	simulation	simulation	NOUN
admet-441	308	36	assessment	assessment	NOUN
admet-441	308	37	using	use	VERB
admet-441	308	38	the	the	DET
admet-441	308	39	"	"	PUNCT
admet-441	308	40	advanced	advanced	ADJ
admet-441	308	41	dissolution	dissolution	NOUN
admet-441	308	42	,	,	PUNCT
admet-441	308	43	absorption	absorption	NOUN
admet-441	308	44	,	,	PUNCT
admet-441	308	45	metabolism	metabolism	NOUN
admet-441	308	46	(	(	PUNCT
admet-441	308	47	adam	adam	PROPN
admet-441	308	48	)	)	PUNCT
admet-441	308	49	"	"	PUNCT
admet-441	308	50	model	model	NOUN
admet-441	308	51	.	.	PUNCT
admet-441	309	1	curr	curr	PROPN
admet-441	309	2	drug	drug	PROPN
admet-441	309	3	metab	metab	PROPN
admet-441	309	4	11	11	NUM
admet-441	309	5	(	(	PUNCT
admet-441	309	6	2010	2010	NUM
admet-441	309	7	)	)	PUNCT
admet-441	309	8	716729	716729	NUM
admet-441	309	9	.	.	PUNCT
admet-441	310	1	[	[	X
admet-441	310	2	57	57	NUM
admet-441	310	3	]	]	PUNCT
admet-441	310	4	a.	a.	NOUN
admet-441	310	5	bruyere	bruyere	PROPN
admet-441	310	6	,	,	PUNCT
admet-441	310	7	x.	x.	NOUN
admet-441	310	8	decleves	decleve	NOUN
admet-441	310	9	,	,	PUNCT
admet-441	310	10	f.	f.	PROPN
admet-441	310	11	bouzom	bouzom	PROPN
admet-441	310	12	,	,	PUNCT
admet-441	310	13	k.	k.	PROPN
admet-441	310	14	ball	ball	PROPN
admet-441	310	15	,	,	PUNCT
admet-441	310	16	c.	c.	PROPN
admet-441	310	17	marques	marques	PROPN
admet-441	310	18	,	,	PUNCT
admet-441	310	19	x.	x.	NOUN
admet-441	310	20	treton	treton	PROPN
admet-441	310	21	,	,	PUNCT
admet-441	310	22	m.	m.	NOUN
admet-441	310	23	pocard	pocard	PROPN
admet-441	310	24	,	,	PUNCT
admet-441	310	25	p.	p.	NOUN
admet-441	310	26	valleur	valleur	PROPN
admet-441	310	27	,	,	PUNCT
admet-441	310	28	y.	y.	PROPN
admet-441	310	29	bouhnik	bouhnik	PROPN
admet-441	310	30	,	,	PUNCT
admet-441	310	31	y.	y.	PROPN
admet-441	310	32	panis	panis	PROPN
admet-441	310	33	,	,	PUNCT
admet-441	310	34	j.m	j.m	PROPN
admet-441	310	35	.	.	PROPN
admet-441	310	36	scherrmann	scherrmann	PROPN
admet-441	310	37	,	,	PUNCT
admet-441	310	38	s.	s.	PROPN
admet-441	310	39	mouly	mouly	PROPN
admet-441	310	40	.	.	PUNCT
admet-441	311	1	effect	effect	NOUN
admet-441	311	2	of	of	ADP
admet-441	311	3	variations	variation	NOUN
admet-441	311	4	in	in	ADP
admet-441	311	5	the	the	DET
admet-441	311	6	amounts	amount	NOUN
admet-441	311	7	of	of	ADP
admet-441	311	8	p	p	NOUN
admet-441	311	9	-	-	PUNCT
admet-441	311	10	glycoprotein	glycoprotein	NOUN
admet-441	311	11	(	(	PUNCT
admet-441	311	12	abcb1	abcb1	NOUN
admet-441	311	13	)	)	PUNCT
admet-441	311	14	,	,	PUNCT
admet-441	311	15	bcrp	bcrp	PROPN
admet-441	311	16	(	(	PUNCT
admet-441	311	17	abcg2	abcg2	NOUN
admet-441	311	18	)	)	PUNCT
admet-441	311	19	and	and	CCONJ
admet-441	311	20	cyp3a4	cyp3a4	NOUN
admet-441	311	21	along	along	ADP
admet-441	311	22	the	the	DET
admet-441	311	23	human	human	ADJ
admet-441	311	24	small	small	ADJ
admet-441	311	25	intestine	intestine	NOUN
admet-441	311	26	on	on	ADP
admet-441	311	27	pbpk	pbpk	NOUN
admet-441	311	28	models	model	NOUN
admet-441	311	29	for	for	ADP
admet-441	311	30	predicting	predict	VERB
admet-441	311	31	intestinal	intestinal	ADJ
admet-441	311	32	first	first	ADJ
admet-441	311	33	pass	pass	NOUN
admet-441	311	34	.	.	PUNCT
admet-441	312	1	mol	mol	ADP
admet-441	312	2	pharm	pharm	NOUN
admet-441	312	3	7	7	NUM
admet-441	312	4	(	(	PUNCT
admet-441	312	5	2010	2010	NUM
admet-441	312	6	)	)	PUNCT
admet-441	312	7	1596	1596	NUM
admet-441	312	8	-	-	SYM
admet-441	312	9	1607	1607	NUM
admet-441	312	10	.	.	PUNCT
admet-441	313	1	[	[	X
admet-441	313	2	58	58	NUM
admet-441	313	3	]	]	PUNCT
admet-441	313	4	a.	a.	NOUN
admet-441	313	5	olivares	olivare	NOUN
admet-441	313	6	-	-	PUNCT
admet-441	313	7	morales	morale	NOUN
admet-441	313	8	,	,	PUNCT
admet-441	313	9	a.	a.	PROPN
admet-441	313	10	ghosh	ghosh	PROPN
admet-441	313	11	,	,	PUNCT
admet-441	313	12	l.	l.	PROPN
admet-441	313	13	aarons	aarons	PROPN
admet-441	313	14	,	,	PUNCT
admet-441	313	15	a.	a.	NOUN
admet-441	313	16	rostami	rostami	PROPN
admet-441	313	17	-	-	PUNCT
admet-441	313	18	hodjegan	hodjegan	PROPN
admet-441	313	19	.	.	PUNCT
admet-441	314	1	development	development	NOUN
admet-441	314	2	of	of	ADP
admet-441	314	3	a	a	DET
admet-441	314	4	novel	novel	NOUN
admet-441	314	5	simplified	simplify	VERB
admet-441	314	6	pbpk	pbpk	ADJ
admet-441	314	7	absorption	absorption	NOUN
admet-441	314	8	model	model	NOUN
admet-441	314	9	to	to	PART
admet-441	314	10	explain	explain	VERB
admet-441	314	11	the	the	DET
admet-441	314	12	higher	high	ADJ
admet-441	314	13	relative	relative	ADJ
admet-441	314	14	bioavailability	bioavailability	NOUN
admet-441	314	15	of	of	ADP
admet-441	314	16	the	the	DET
admet-441	314	17	oros(r	oros(r	ADJ
admet-441	314	18	)	)	PUNCT
admet-441	314	19	formulation	formulation	NOUN
admet-441	314	20	of	of	ADP
admet-441	314	21	oxybutynin	oxybutynin	PROPN
admet-441	314	22	.	.	PUNCT
admet-441	315	1	aaps	aap	NOUN
admet-441	316	1	j	j	PROPN
admet-441	316	2	18	18	NUM
admet-441	316	3	(	(	PUNCT
admet-441	316	4	2016	2016	NUM
admet-441	316	5	)	)	PUNCT
admet-441	316	6	1532	1532	NUM
admet-441	316	7	-	-	SYM
admet-441	316	8	1549	1549	NUM
admet-441	316	9	.	.	PUNCT
admet-441	317	1	[	[	X
admet-441	317	2	59	59	NUM
admet-441	317	3	]	]	X
admet-441	317	4	m.s	m.s	PROPN
admet-441	317	5	.	.	PROPN
admet-441	317	6	alavijeh	alavijeh	PROPN
admet-441	317	7	,	,	PUNCT
admet-441	317	8	m.	m.	NOUN
admet-441	317	9	chishty	chishty	NOUN
admet-441	317	10	,	,	PUNCT
admet-441	317	11	m.z	m.z	PROPN
admet-441	317	12	.	.	PROPN
admet-441	317	13	qaiser	qaiser	PROPN
admet-441	317	14	,	,	PUNCT
admet-441	317	15	a.m.	a.m.	PROPN
admet-441	317	16	palmer	palmer	PROPN
admet-441	317	17	.	.	PUNCT
admet-441	317	18	drug	drug	NOUN
admet-441	317	19	metabolism	metabolism	NOUN
admet-441	317	20	and	and	CCONJ
admet-441	317	21	pharmacokinetics	pharmacokinetic	NOUN
admet-441	317	22	,	,	PUNCT
admet-441	317	23	the	the	DET
admet-441	317	24	blood	blood	NOUN
admet-441	317	25	-	-	PUNCT
admet-441	317	26	brain	brain	NOUN
admet-441	317	27	barrier	barrier	NOUN
admet-441	317	28	,	,	PUNCT
admet-441	317	29	and	and	CCONJ
admet-441	317	30	central	central	ADJ
admet-441	317	31	nervous	nervous	ADJ
admet-441	317	32	system	system	NOUN
admet-441	317	33	drug	drug	NOUN
admet-441	317	34	discovery	discovery	NOUN
admet-441	317	35	.	.	PUNCT
admet-441	318	1	neurorx	neurorx	PROPN
admet-441	318	2	2	2	NUM
admet-441	318	3	(	(	PUNCT
admet-441	318	4	2005	2005	NUM
admet-441	318	5	)	)	PUNCT
admet-441	318	6	554	554	NUM
admet-441	318	7	-	-	SYM
admet-441	318	8	571	571	NUM
admet-441	318	9	.	.	PUNCT
admet-441	319	1	[	[	X
admet-441	319	2	60	60	NUM
admet-441	319	3	]	]	PUNCT
admet-441	319	4	m.	m.	NOUN
admet-441	319	5	feher	feher	PROPN
admet-441	319	6	,	,	PUNCT
admet-441	319	7	e.	e.	PROPN
admet-441	319	8	sourial	sourial	PROPN
admet-441	319	9	,	,	PUNCT
admet-441	319	10	j.m	j.m	PROPN
admet-441	319	11	.	.	PROPN
admet-441	319	12	schmidt	schmidt	PROPN
admet-441	319	13	.	.	PUNCT
admet-441	320	1	a	a	DET
admet-441	320	2	simple	simple	ADJ
admet-441	320	3	model	model	NOUN
admet-441	320	4	for	for	ADP
admet-441	320	5	the	the	DET
admet-441	320	6	prediction	prediction	NOUN
admet-441	320	7	of	of	ADP
admet-441	320	8	blood	blood	NOUN
admet-441	320	9	-	-	PUNCT
admet-441	320	10	brain	brain	NOUN
admet-441	320	11	partitioning	partitioning	NOUN
admet-441	320	12	.	.	PUNCT
admet-441	321	1	int	int	PROPN
admet-441	321	2	j	j	PROPN
admet-441	321	3	pharm	pharm	PROPN
admet-441	321	4	201	201	NUM
admet-441	321	5	(	(	PUNCT
admet-441	321	6	2000	2000	NUM
admet-441	321	7	)	)	PUNCT
admet-441	321	8	239	239	NUM
admet-441	321	9	-	-	SYM
admet-441	321	10	247	247	NUM
admet-441	321	11	.	.	PUNCT
admet-441	322	1	[	[	X
admet-441	322	2	61	61	NUM
admet-441	322	3	]	]	PUNCT
admet-441	322	4	s.	s.	PROPN
admet-441	322	5	vilar	vilar	PROPN
admet-441	322	6	,	,	PUNCT
admet-441	322	7	m.	m.	NOUN
admet-441	322	8	chakrabarti	chakrabarti	PROPN
admet-441	322	9	,	,	PUNCT
admet-441	322	10	s.	s.	PROPN
admet-441	322	11	costanzi	costanzi	PROPN
admet-441	322	12	.	.	PUNCT
admet-441	323	1	prediction	prediction	NOUN
admet-441	323	2	of	of	ADP
admet-441	323	3	passive	passive	ADJ
admet-441	323	4	blood	blood	NOUN
admet-441	323	5	-	-	PUNCT
admet-441	323	6	brain	brain	NOUN
admet-441	323	7	partitioning	partitioning	NOUN
admet-441	323	8	:	:	PUNCT
admet-441	323	9	straightforward	straightforward	ADJ
admet-441	323	10	and	and	CCONJ
admet-441	323	11	effective	effective	ADJ
admet-441	323	12	classification	classification	NOUN
admet-441	323	13	models	model	NOUN
admet-441	323	14	based	base	VERB
admet-441	323	15	on	on	ADP
admet-441	323	16	in	in	ADP
admet-441	323	17	silico	silico	NOUN
admet-441	323	18	derived	derive	VERB
admet-441	323	19	physicochemical	physicochemical	ADJ
admet-441	323	20	descriptors	descriptor	NOUN
admet-441	323	21	.	.	PUNCT
admet-441	324	1	j	j	PROPN
admet-441	324	2	mol	mol	ADP
admet-441	324	3	graph	graph	NOUN
admet-441	324	4	model	model	NOUN
admet-441	324	5	28	28	NUM
admet-441	324	6	(	(	PUNCT
admet-441	324	7	2010	2010	NUM
admet-441	324	8	)	)	PUNCT
admet-441	324	9	899	899	NUM
admet-441	324	10	-	-	SYM
admet-441	324	11	903	903	NUM
admet-441	324	12	.	.	PUNCT
admet-441	325	1	[	[	X
admet-441	325	2	62	62	NUM
admet-441	325	3	]	]	X
admet-441	325	4	j.a	j.a	PROPN
admet-441	325	5	.	.	PROPN
admet-441	325	6	platts	platts	PROPN
admet-441	325	7	,	,	PUNCT
admet-441	325	8	m.h	m.h	PROPN
admet-441	325	9	.	.	PROPN
admet-441	325	10	abraham	abraham	PROPN
admet-441	325	11	,	,	PUNCT
admet-441	325	12	y.h	y.h	PROPN
admet-441	325	13	.	.	PROPN
admet-441	325	14	zhao	zhao	PROPN
admet-441	325	15	,	,	PUNCT
admet-441	325	16	a.	a.	PROPN
admet-441	325	17	hersey	hersey	PROPN
admet-441	325	18	,	,	PUNCT
admet-441	325	19	l.	l.	PROPN
admet-441	325	20	ijaz	ijaz	PROPN
admet-441	325	21	,	,	PUNCT
admet-441	325	22	d.	d.	PROPN
admet-441	325	23	butina	butina	PROPN
admet-441	325	24	.	.	PUNCT
admet-441	326	1	correlation	correlation	NOUN
admet-441	326	2	and	and	CCONJ
admet-441	326	3	prediction	prediction	NOUN
admet-441	326	4	of	of	ADP
admet-441	326	5	a	a	DET
admet-441	326	6	large	large	ADJ
admet-441	326	7	blood	blood	NOUN
admet-441	326	8	-	-	PUNCT
admet-441	326	9	brain	brain	NOUN
admet-441	326	10	distribution	distribution	NOUN
admet-441	326	11	data	datum	NOUN
admet-441	326	12	set	set	VERB
admet-441	326	13	--	--	PUNCT
admet-441	326	14	an	an	DET
admet-441	326	15	lfer	lfer	NOUN
admet-441	326	16	study	study	NOUN
admet-441	326	17	.	.	PUNCT
admet-441	327	1	eur	eur	PROPN
admet-441	327	2	j	j	PROPN
admet-441	327	3	med	med	PROPN
admet-441	327	4	chem	chem	NOUN
admet-441	327	5	36	36	NUM
admet-441	327	6	(	(	PUNCT
admet-441	327	7	2001	2001	NUM
admet-441	327	8	)	)	PUNCT
admet-441	327	9	719	719	NUM
admet-441	327	10	-	-	SYM
admet-441	327	11	730	730	NUM
admet-441	327	12	.	.	PUNCT
admet-441	328	1	[	[	X
admet-441	328	2	63	63	NUM
admet-441	328	3	]	]	SYM
admet-441	328	4	n.j	n.j	PROPN
admet-441	328	5	.	.	PROPN
admet-441	328	6	abbott	abbott	PROPN
admet-441	328	7	,	,	PUNCT
admet-441	328	8	a.a	a.a	PROPN
admet-441	328	9	.	.	PROPN
admet-441	328	10	patabendige	patabendige	PROPN
admet-441	328	11	,	,	PUNCT
admet-441	328	12	d.e	d.e	PROPN
admet-441	328	13	.	.	PROPN
admet-441	328	14	dolman	dolman	PROPN
admet-441	328	15	,	,	PUNCT
admet-441	328	16	s.r	s.r	PROPN
admet-441	328	17	.	.	PROPN
admet-441	328	18	yusof	yusof	PROPN
admet-441	328	19	,	,	PUNCT
admet-441	328	20	d.j	d.j	PROPN
admet-441	328	21	.	.	PROPN
admet-441	328	22	begley	begley	PROPN
admet-441	328	23	.	.	PUNCT
admet-441	329	1	structure	structure	NOUN
admet-441	329	2	and	and	CCONJ
admet-441	329	3	function	function	NOUN
admet-441	329	4	of	of	ADP
admet-441	329	5	the	the	DET
admet-441	329	6	blood	blood	NOUN
admet-441	329	7	-	-	PUNCT
admet-441	329	8	brain	brain	NOUN
admet-441	329	9	barrier	barrier	NOUN
admet-441	329	10	.	.	PUNCT
admet-441	330	1	neurobiol	neurobiol	PROPN
admet-441	330	2	dis	dis	PROPN
admet-441	330	3	37	37	NUM
admet-441	330	4	(	(	PUNCT
admet-441	330	5	2010	2010	NUM
admet-441	330	6	)	)	PUNCT
admet-441	330	7	13	13	NUM
admet-441	330	8	-	-	SYM
admet-441	330	9	25	25	NUM
admet-441	330	10	.	.	PUNCT
admet-441	331	1	[	[	X
admet-441	331	2	64	64	NUM
admet-441	331	3	]	]	X
admet-441	331	4	y.	y.	PROPN
admet-441	331	5	yamamoto	yamamoto	PROPN
admet-441	331	6	,	,	PUNCT
admet-441	331	7	p.a	p.a	PROPN
admet-441	331	8	.	.	PROPN
admet-441	331	9	valitalo	valitalo	PROPN
admet-441	331	10	,	,	PUNCT
admet-441	331	11	d.j	d.j	PROPN
admet-441	331	12	.	.	PROPN
admet-441	331	13	van	van	PROPN
admet-441	331	14	den	den	PROPN
admet-441	331	15	berg	berg	PROPN
admet-441	331	16	,	,	PUNCT
admet-441	331	17	r.	r.	PROPN
admet-441	331	18	hartman	hartman	PROPN
admet-441	331	19	,	,	PUNCT
admet-441	331	20	w.	w.	PROPN
admet-441	331	21	van	van	PROPN
admet-441	331	22	den	den	PROPN
admet-441	331	23	brink	brink	PROPN
admet-441	331	24	,	,	PUNCT
admet-441	331	25	y.c	y.c	PROPN
admet-441	331	26	.	.	PROPN
admet-441	331	27	wong	wong	PROPN
admet-441	331	28	,	,	PUNCT
admet-441	331	29	d.r	d.r	PROPN
admet-441	331	30	.	.	PROPN
admet-441	331	31	huntjens	huntjens	PROPN
admet-441	331	32	,	,	PUNCT
admet-441	331	33	j.h	j.h	PROPN
admet-441	331	34	.	.	PROPN
admet-441	331	35	proost	proost	PROPN
admet-441	331	36	,	,	PUNCT
admet-441	331	37	a.	a.	PROPN
admet-441	331	38	vermeulen	vermeulen	PROPN
admet-441	331	39	,	,	PUNCT
admet-441	331	40	w.	w.	PROPN
admet-441	331	41	krauwinkel	krauwinkel	PROPN
admet-441	331	42	,	,	PUNCT
admet-441	331	43	s.	s.	PROPN
admet-441	331	44	bakshi	bakshi	PROPN
admet-441	331	45	,	,	PUNCT
admet-441	331	46	v.	v.	ADP
admet-441	331	47	aranzana	aranzana	NOUN
admet-441	331	48	-	-	PUNCT
admet-441	331	49	climent	climent	PROPN
admet-441	331	50	,	,	PUNCT
admet-441	331	51	s.	s.	PROPN
admet-441	331	52	marchand	marchand	PROPN
admet-441	331	53	,	,	PUNCT
admet-441	331	54	c.	c.	PROPN
admet-441	331	55	dahyot	dahyot	PROPN
admet-441	331	56	-	-	PUNCT
admet-441	331	57	fizelier	fizelier	NOUN
admet-441	331	58	,	,	PUNCT
admet-441	331	59	w.	w.	PROPN
admet-441	331	60	couet	couet	PROPN
admet-441	331	61	,	,	PUNCT
admet-441	331	62	m.	m.	NOUN
admet-441	331	63	danhof	danhof	NOUN
admet-441	331	64	,	,	PUNCT
admet-441	331	65	j.g	j.g	PROPN
admet-441	331	66	.	.	PROPN
admet-441	331	67	van	van	PROPN
admet-441	331	68	hasselt	hasselt	PROPN
admet-441	331	69	,	,	PUNCT
admet-441	331	70	e.c	e.c	PROPN
admet-441	331	71	.	.	PROPN
admet-441	331	72	de	de	X
admet-441	331	73	lange	lange	PROPN
admet-441	331	74	.	.	PUNCT
admet-441	332	1	a	a	DET
admet-441	332	2	generic	generic	ADJ
admet-441	332	3	multicompartmental	multicompartmental	NOUN
admet-441	332	4	cns	cns	NOUN
admet-441	332	5	distribution	distribution	NOUN
admet-441	332	6	model	model	NOUN
admet-441	332	7	structure	structure	NOUN
admet-441	332	8	for	for	ADP
admet-441	332	9	9	9	NUM
admet-441	332	10	drugs	drug	NOUN
admet-441	332	11	allows	allow	VERB
admet-441	332	12	prediction	prediction	NOUN
admet-441	332	13	of	of	ADP
admet-441	332	14	human	human	ADJ
admet-441	332	15	brain	brain	NOUN
admet-441	332	16	target	target	NOUN
admet-441	332	17	site	site	NOUN
admet-441	332	18	concentrations	concentration	NOUN
admet-441	332	19	.	.	PUNCT
admet-441	333	1	pharm	pharm	NOUN
admet-441	333	2	res	re	VERB
admet-441	333	3	34	34	NUM
admet-441	333	4	(	(	PUNCT
admet-441	333	5	2017	2017	NUM
admet-441	333	6	)	)	PUNCT
admet-441	333	7	333	333	NUM
admet-441	333	8	-	-	SYM
admet-441	333	9	351	351	NUM
admet-441	333	10	.	.	PUNCT
admet-441	334	1	admet	admet	PROPN
admet-441	334	2	&	&	CCONJ
admet-441	334	3	dmpk	dmpk	PROPN
admet-441	334	4	5(4	5(4	NOUN
admet-441	334	5	)	)	PUNCT
admet-441	334	6	(	(	PUNCT
admet-441	334	7	2017	2017	NUM
admet-441	334	8	)	)	PUNCT
admet-441	334	9	201	201	NUM
admet-441	334	10	-	-	SYM
admet-441	334	11	211	211	NUM
admet-441	334	12	utilizing	utilize	VERB
admet-441	334	13	in	in	ADP
admet-441	334	14	vitro	vitro	X
admet-441	334	15	transporter	transporter	NOUN
admet-441	334	16	data	datum	NOUN
admet-441	334	17	in	in	ADP
admet-441	334	18	ivive	ivive	ADJ
admet-441	334	19	-	-	PUNCT
admet-441	334	20	pbpk	pbpk	ADJ
admet-441	334	21	doi	doi	NOUN
admet-441	334	22	:	:	PUNCT
admet-441	334	23	10.5599	10.5599	NUM
admet-441	334	24	/	/	SYM
admet-441	334	25	admet.5.4.441	admet.5.4.441	NOUN
admet-441	334	26	211	211	NUM
admet-441	335	1	[	[	X
admet-441	335	2	65	65	NUM
admet-441	335	3	]	]	PUNCT
admet-441	335	4	a.m.	a.m.	PROPN
admet-441	335	5	palmer	palmer	PROPN
admet-441	335	6	,	,	PUNCT
admet-441	335	7	m.s	m.s	PROPN
admet-441	335	8	.	.	PROPN
admet-441	335	9	alavijeh	alavijeh	PROPN
admet-441	335	10	.	.	PUNCT
admet-441	336	1	translational	translational	ADJ
admet-441	336	2	cns	cns	PROPN
admet-441	336	3	medicines	medicine	NOUN
admet-441	336	4	research	research	NOUN
admet-441	336	5	.	.	PUNCT
admet-441	337	1	drug	drug	NOUN
admet-441	337	2	discov	discov	PROPN
admet-441	337	3	today	today	NOUN
admet-441	337	4	17	17	NUM
admet-441	337	5	(	(	PUNCT
admet-441	337	6	2012	2012	NUM
admet-441	337	7	)	)	PUNCT
admet-441	337	8	1068	1068	NUM
admet-441	337	9	-	-	SYM
admet-441	337	10	1078	1078	NUM
admet-441	337	11	.	.	PUNCT
admet-441	338	1	[	[	X
admet-441	338	2	66	66	NUM
admet-441	338	3	]	]	X
admet-441	338	4	a.k	a.k	PROPN
admet-441	338	5	.	.	PROPN
admet-441	338	6	deo	deo	PROPN
admet-441	338	7	,	,	PUNCT
admet-441	338	8	f.p	f.p	PROPN
admet-441	338	9	.	.	PROPN
admet-441	338	10	theil	theil	PROPN
admet-441	338	11	,	,	PUNCT
admet-441	338	12	j.m	j.m	PROPN
admet-441	338	13	.	.	PROPN
admet-441	338	14	nicolas	nicolas	PROPN
admet-441	338	15	.	.	PUNCT
admet-441	338	16	confounding	confound	VERB
admet-441	338	17	parameters	parameter	NOUN
admet-441	338	18	in	in	ADP
admet-441	338	19	preclinical	preclinical	ADJ
admet-441	338	20	assessment	assessment	NOUN
admet-441	338	21	of	of	ADP
admet-441	338	22	blood	blood	NOUN
admet-441	338	23	-	-	PUNCT
admet-441	338	24	brain	brain	NOUN
admet-441	338	25	barrier	barrier	NOUN
admet-441	338	26	permeation	permeation	NOUN
admet-441	338	27	:	:	PUNCT
admet-441	338	28	an	an	DET
admet-441	338	29	overview	overview	NOUN
admet-441	338	30	with	with	ADP
admet-441	338	31	emphasis	emphasis	NOUN
admet-441	338	32	on	on	ADP
admet-441	338	33	species	specie	NOUN
admet-441	338	34	differences	difference	NOUN
admet-441	338	35	and	and	CCONJ
admet-441	338	36	effect	effect	NOUN
admet-441	338	37	of	of	ADP
admet-441	338	38	disease	disease	NOUN
admet-441	338	39	states	state	NOUN
admet-441	338	40	.	.	PUNCT
admet-441	339	1	mol	mol	ADP
admet-441	339	2	pharm	pharm	NOUN
admet-441	339	3	10	10	NUM
admet-441	339	4	(	(	PUNCT
admet-441	339	5	2013	2013	NUM
admet-441	339	6	)	)	PUNCT
admet-441	339	7	1581	1581	NUM
admet-441	339	8	-	-	SYM
admet-441	339	9	1595	1595	NUM
admet-441	339	10	.	.	PUNCT
admet-441	340	1	[	[	X
admet-441	340	2	67	67	NUM
admet-441	340	3	]	]	X
admet-441	340	4	f.	f.	PROPN
admet-441	340	5	fenneteau	fenneteau	PROPN
admet-441	340	6	,	,	PUNCT
admet-441	340	7	p.	p.	PROPN
admet-441	340	8	poulin	poulin	PROPN
admet-441	340	9	,	,	PUNCT
admet-441	340	10	f.	f.	PROPN
admet-441	340	11	nekka	nekka	PROPN
admet-441	340	12	.	.	PUNCT
admet-441	341	1	physiologically	physiologically	ADV
admet-441	341	2	based	base	VERB
admet-441	341	3	predictions	prediction	NOUN
admet-441	341	4	of	of	ADP
admet-441	341	5	the	the	DET
admet-441	341	6	impact	impact	NOUN
admet-441	341	7	of	of	ADP
admet-441	341	8	inhibition	inhibition	NOUN
admet-441	341	9	of	of	ADP
admet-441	341	10	intestinal	intestinal	ADJ
admet-441	341	11	and	and	CCONJ
admet-441	341	12	hepatic	hepatic	ADJ
admet-441	341	13	metabolism	metabolism	NOUN
admet-441	341	14	on	on	ADP
admet-441	341	15	human	human	ADJ
admet-441	341	16	pharmacokinetics	pharmacokinetic	NOUN
admet-441	341	17	of	of	ADP
admet-441	341	18	cyp3a	cyp3a	NOUN
admet-441	341	19	substrates	substrate	NOUN
admet-441	341	20	.	.	PUNCT
admet-441	342	1	j	j	PROPN
admet-441	342	2	pharm	pharm	PROPN
admet-441	342	3	sci	sci	PROPN
admet-441	342	4	99	99	NUM
admet-441	342	5	(	(	PUNCT
admet-441	342	6	2010	2010	NUM
admet-441	342	7	)	)	PUNCT
admet-441	342	8	486	486	NUM
admet-441	342	9	-	-	SYM
admet-441	342	10	514	514	NUM
admet-441	342	11	.	.	PUNCT
admet-441	343	1	[	[	X
admet-441	343	2	68	68	NUM
admet-441	343	3	]	]	PUNCT
admet-441	343	4	k.	k.	PROPN
admet-441	343	5	ball	ball	PROPN
admet-441	343	6	,	,	PUNCT
admet-441	343	7	f.	f.	PROPN
admet-441	343	8	bouzom	bouzom	PROPN
admet-441	343	9	,	,	PUNCT
admet-441	343	10	j.m	j.m	PROPN
admet-441	343	11	.	.	PROPN
admet-441	343	12	scherrmann	scherrmann	PROPN
admet-441	343	13	,	,	PUNCT
admet-441	343	14	b.	b.	PROPN
admet-441	343	15	walther	walther	PROPN
admet-441	343	16	,	,	PUNCT
admet-441	343	17	x.	x.	NOUN
admet-441	343	18	decleves	decleve	NOUN
admet-441	343	19	.	.	PUNCT
admet-441	344	1	physiologically	physiologically	ADV
admet-441	344	2	based	base	VERB
admet-441	344	3	pharmacokinetic	pharmacokinetic	ADJ
admet-441	344	4	modelling	modelling	NOUN
admet-441	344	5	of	of	ADP
admet-441	344	6	drug	drug	NOUN
admet-441	344	7	penetration	penetration	NOUN
admet-441	344	8	across	across	ADP
admet-441	344	9	the	the	DET
admet-441	344	10	blood	blood	NOUN
admet-441	344	11	-	-	PUNCT
admet-441	344	12	brain	brain	NOUN
admet-441	344	13	barrier	barrier	NOUN
admet-441	344	14	--	--	PUNCT
admet-441	344	15	towards	towards	ADP
admet-441	344	16	a	a	DET
admet-441	344	17	mechanistic	mechanistic	ADJ
admet-441	344	18	ivive	ivive	ADJ
admet-441	344	19	-	-	PUNCT
admet-441	344	20	based	base	VERB
admet-441	344	21	approach	approach	NOUN
admet-441	344	22	.	.	PUNCT
admet-441	345	1	aaps	aap	NOUN
admet-441	345	2	j	j	PROPN
admet-441	345	3	15	15	NUM
admet-441	345	4	(	(	PUNCT
admet-441	345	5	2013	2013	NUM
admet-441	345	6	)	)	PUNCT
admet-441	345	7	913	913	NUM
admet-441	345	8	-	-	SYM
admet-441	345	9	932	932	NUM
admet-441	345	10	.	.	PUNCT
admet-441	346	1	[	[	X
admet-441	346	2	69	69	NUM
admet-441	346	3	]	]	PUNCT
admet-441	346	4	k.	k.	PROPN
admet-441	346	5	ball	ball	PROPN
admet-441	346	6	,	,	PUNCT
admet-441	346	7	f.	f.	PROPN
admet-441	346	8	bouzom	bouzom	PROPN
admet-441	346	9	,	,	PUNCT
admet-441	346	10	j.m	j.m	PROPN
admet-441	346	11	.	.	PROPN
admet-441	346	12	scherrmann	scherrmann	PROPN
admet-441	346	13	,	,	PUNCT
admet-441	346	14	b.	b.	PROPN
admet-441	346	15	walther	walther	PROPN
admet-441	346	16	,	,	PUNCT
admet-441	346	17	x.	x.	NOUN
admet-441	346	18	decleves	decleve	NOUN
admet-441	346	19	.	.	PUNCT
admet-441	347	1	development	development	NOUN
admet-441	347	2	of	of	ADP
admet-441	347	3	a	a	DET
admet-441	347	4	physiologically	physiologically	ADV
admet-441	347	5	based	base	VERB
admet-441	347	6	pharmacokinetic	pharmacokinetic	ADJ
admet-441	347	7	model	model	NOUN
admet-441	347	8	for	for	ADP
admet-441	347	9	the	the	DET
admet-441	347	10	rat	rat	NOUN
admet-441	347	11	central	central	ADJ
admet-441	347	12	nervous	nervous	ADJ
admet-441	347	13	system	system	NOUN
admet-441	347	14	and	and	CCONJ
admet-441	347	15	determination	determination	NOUN
admet-441	347	16	of	of	ADP
admet-441	347	17	an	an	DET
admet-441	347	18	in	in	X
admet-441	347	19	vitro	vitro	NOUN
admet-441	347	20	-	-	PUNCT
admet-441	347	21	in	in	ADP
admet-441	347	22	vivo	vivo	NOUN
admet-441	347	23	scaling	scaling	NOUN
admet-441	347	24	methodology	methodology	NOUN
admet-441	347	25	for	for	ADP
admet-441	347	26	the	the	DET
admet-441	347	27	blood	blood	NOUN
admet-441	347	28	-	-	PUNCT
admet-441	347	29	brain	brain	NOUN
admet-441	347	30	barrier	barrier	NOUN
admet-441	347	31	permeability	permeability	NOUN
admet-441	347	32	of	of	ADP
admet-441	347	33	two	two	NUM
admet-441	347	34	transporter	transporter	NOUN
admet-441	347	35	substrates	substrate	NOUN
admet-441	347	36	,	,	PUNCT
admet-441	347	37	morphine	morphine	NOUN
admet-441	347	38	and	and	CCONJ
admet-441	347	39	oxycodone	oxycodone	NOUN
admet-441	347	40	.	.	PUNCT
admet-441	348	1	j	j	PROPN
admet-441	348	2	pharm	pharm	PROPN
admet-441	348	3	sci	sci	PROPN
admet-441	348	4	101	101	NUM
admet-441	348	5	(	(	PUNCT
admet-441	348	6	2012	2012	NUM
admet-441	348	7	)	)	PUNCT
admet-441	348	8	4277	4277	NUM
admet-441	348	9	-	-	PUNCT
admet-441	348	10	4292	4292	NUM
admet-441	348	11	.	.	PUNCT
admet-441	349	1	[	[	X
admet-441	349	2	70	70	NUM
admet-441	349	3	]	]	X
admet-441	349	4	n.	n.	PROPN
admet-441	349	5	notkina	notkina	PROPN
admet-441	349	6	,	,	PUNCT
admet-441	349	7	c.	c.	PROPN
admet-441	349	8	dahyot	dahyot	PROPN
admet-441	349	9	-	-	PUNCT
admet-441	349	10	fizelier	fizelier	NOUN
admet-441	349	11	,	,	PUNCT
admet-441	349	12	a.k	a.k	PROPN
admet-441	349	13	.	.	PROPN
admet-441	349	14	gupta	gupta	PROPN
admet-441	349	15	.	.	PUNCT
admet-441	350	1	in	in	ADP
admet-441	350	2	vivo	vivo	ADJ
admet-441	350	3	microdialysis	microdialysis	NOUN
admet-441	350	4	in	in	ADP
admet-441	350	5	pharmacological	pharmacological	ADJ
admet-441	350	6	studies	study	NOUN
admet-441	350	7	of	of	ADP
admet-441	350	8	antibacterial	antibacterial	ADJ
admet-441	350	9	agents	agent	NOUN
admet-441	350	10	in	in	ADP
admet-441	350	11	the	the	DET
admet-441	350	12	brain	brain	NOUN
admet-441	350	13	.	.	PUNCT
admet-441	351	1	br	br	PROPN
admet-441	352	1	j	j	PROPN
admet-441	352	2	anaesth	anaesth	PROPN
admet-441	352	3	109	109	NUM
admet-441	352	4	(	(	PUNCT
admet-441	352	5	2012	2012	NUM
admet-441	352	6	)	)	PUNCT
admet-441	352	7	155	155	NUM
admet-441	352	8	-	-	SYM
admet-441	352	9	160	160	NUM
admet-441	352	10	.	.	PUNCT
admet-441	353	1	[	[	X
admet-441	353	2	71	71	NUM
admet-441	353	3	]	]	X
admet-441	353	4	w.c.-y	w.c.-y	NOUN
admet-441	353	5	.	.	PUNCT
admet-441	354	1	benet	benet	PROPN
admet-441	354	2	lz	lz	PROPN
admet-441	354	3	,	,	PUNCT
admet-441	354	4	hebert	hebert	NOUN
admet-441	354	5	mf	mf	NOUN
admet-441	354	6	,	,	PUNCT
admet-441	354	7	wacher	wacher	NOUN
admet-441	354	8	vj	vj	NOUN
admet-441	354	9	.	.	PUNCT
admet-441	354	10	intestinal	intestinal	ADJ
admet-441	354	11	drug	drug	NOUN
admet-441	354	12	metabolism	metabolism	NOUN
admet-441	354	13	and	and	CCONJ
admet-441	354	14	antitransport	antitransport	NOUN
admet-441	354	15	processes	process	NOUN
admet-441	354	16	:	:	PUNCT
admet-441	354	17	a	a	DET
admet-441	354	18	potential	potential	ADJ
admet-441	354	19	paradigm	paradigm	NOUN
admet-441	354	20	shift	shift	NOUN
admet-441	354	21	in	in	ADP
admet-441	354	22	oral	oral	ADJ
admet-441	354	23	drug	drug	NOUN
admet-441	354	24	delivery	delivery	NOUN
admet-441	354	25	.	.	PUNCT
admet-441	355	1	journal	journal	PROPN
admet-441	355	2	of	of	ADP
admet-441	355	3	controlled	control	VERB
admet-441	355	4	release	release	NOUN
admet-441	355	5	2	2	NUM
admet-441	355	6	(	(	PUNCT
admet-441	355	7	1996	1996	NUM
admet-441	355	8	)	)	PUNCT
admet-441	355	9	139–143	139–143	NUM
admet-441	355	10	.	.	PUNCT
admet-441	356	1	[	[	X
admet-441	356	2	72	72	NUM
admet-441	356	3	]	]	SYM
admet-441	356	4	v.j	v.j	PROPN
admet-441	356	5	.	.	PROPN
admet-441	356	6	wacher	wacher	PROPN
admet-441	356	7	,	,	PUNCT
admet-441	356	8	l.	l.	PROPN
admet-441	356	9	salphati	salphati	PROPN
admet-441	356	10	,	,	PUNCT
admet-441	356	11	l.z	l.z	PROPN
admet-441	356	12	.	.	PROPN
admet-441	356	13	benet	benet	PROPN
admet-441	356	14	.	.	PUNCT
admet-441	357	1	active	active	ADJ
admet-441	357	2	secretion	secretion	NOUN
admet-441	357	3	and	and	CCONJ
admet-441	357	4	enterocytic	enterocytic	ADJ
admet-441	357	5	drug	drug	NOUN
admet-441	357	6	metabolism	metabolism	NOUN
admet-441	357	7	barriers	barrier	NOUN
admet-441	357	8	to	to	ADP
admet-441	357	9	drug	drug	NOUN
admet-441	357	10	absorption	absorption	NOUN
admet-441	357	11	.	.	PUNCT
admet-441	358	1	adv	adv	PROPN
admet-441	358	2	drug	drug	PROPN
admet-441	358	3	deliv	deliv	NOUN
admet-441	358	4	rev	rev	VERB
admet-441	358	5	46	46	NUM
admet-441	358	6	(	(	PUNCT
admet-441	358	7	2001	2001	NUM
admet-441	358	8	)	)	PUNCT
admet-441	358	9	89	89	NUM
admet-441	358	10	-	-	SYM
admet-441	358	11	102	102	NUM
admet-441	358	12	.	.	PUNCT
admet-441	359	1	[	[	X
admet-441	359	2	73	73	NUM
admet-441	359	3	]	]	X
admet-441	359	4	y.y	y.y	PROPN
admet-441	359	5	.	.	PROPN
admet-441	359	6	lau	lau	PROPN
admet-441	359	7	,	,	PUNCT
admet-441	359	8	y.	y.	PROPN
admet-441	359	9	huang	huang	PROPN
admet-441	359	10	,	,	PUNCT
admet-441	359	11	l.	l.	PROPN
admet-441	359	12	frassetto	frassetto	PROPN
admet-441	359	13	,	,	PUNCT
admet-441	359	14	l.z	l.z	PROPN
admet-441	359	15	.	.	PROPN
admet-441	359	16	benet	benet	PROPN
admet-441	359	17	.	.	PUNCT
admet-441	360	1	effect	effect	NOUN
admet-441	360	2	of	of	ADP
admet-441	360	3	oatp1b	oatp1b	PROPN
admet-441	360	4	transporter	transporter	NOUN
admet-441	360	5	inhibition	inhibition	NOUN
admet-441	360	6	on	on	ADP
admet-441	360	7	the	the	DET
admet-441	360	8	pharmacokinetics	pharmacokinetic	NOUN
admet-441	360	9	of	of	ADP
admet-441	360	10	atorvastatin	atorvastatin	NOUN
admet-441	360	11	in	in	ADP
admet-441	360	12	healthy	healthy	ADJ
admet-441	360	13	volunteers	volunteer	NOUN
admet-441	360	14	.	.	PUNCT
admet-441	361	1	clin	clin	PROPN
admet-441	361	2	pharmacol	pharmacol	PROPN
admet-441	361	3	ther	ther	ADV
admet-441	361	4	81	81	NUM
admet-441	361	5	(	(	PUNCT
admet-441	361	6	2007	2007	NUM
admet-441	361	7	)	)	PUNCT
admet-441	361	8	194	194	NUM
admet-441	361	9	-	-	SYM
admet-441	361	10	204	204	NUM
admet-441	361	11	.	.	PUNCT
admet-441	362	1	[	[	X
admet-441	362	2	74	74	NUM
admet-441	362	3	]	]	X
admet-441	362	4	j.a	j.a	PROPN
admet-441	362	5	.	.	PROPN
admet-441	362	6	grillo	grillo	PROPN
admet-441	362	7	,	,	PUNCT
admet-441	362	8	p.	p.	PROPN
admet-441	362	9	zhao	zhao	PROPN
admet-441	362	10	,	,	PUNCT
admet-441	362	11	j.	j.	PROPN
admet-441	362	12	bullock	bullock	PROPN
admet-441	362	13	,	,	PUNCT
admet-441	362	14	b.p	b.p	PROPN
admet-441	362	15	.	.	PROPN
admet-441	362	16	booth	booth	PROPN
admet-441	362	17	,	,	PUNCT
admet-441	362	18	m.	m.	PROPN
admet-441	362	19	lu	lu	PROPN
admet-441	362	20	,	,	PUNCT
admet-441	362	21	k.	k.	PROPN
admet-441	362	22	robie	robie	PROPN
admet-441	362	23	-	-	PUNCT
admet-441	362	24	suh	suh	PROPN
admet-441	362	25	,	,	PUNCT
admet-441	362	26	e.g.	e.g.	ADV
admet-441	362	27	berglund	berglund	PROPN
admet-441	362	28	,	,	PUNCT
admet-441	362	29	k.s	k.s	PROPN
admet-441	362	30	.	.	PROPN
admet-441	362	31	pang	pang	PROPN
admet-441	362	32	,	,	PUNCT
admet-441	362	33	a.	a.	PROPN
admet-441	362	34	rahman	rahman	PROPN
admet-441	362	35	,	,	PUNCT
admet-441	362	36	l.	l.	PROPN
admet-441	362	37	zhang	zhang	PROPN
admet-441	362	38	,	,	PUNCT
admet-441	362	39	l.j	l.j	PROPN
admet-441	362	40	.	.	PROPN
admet-441	362	41	lesko	lesko	PROPN
admet-441	362	42	,	,	PUNCT
admet-441	362	43	s.m	s.m	PROPN
admet-441	362	44	.	.	PROPN
admet-441	362	45	huang	huang	PROPN
admet-441	362	46	.	.	PUNCT
admet-441	362	47	utility	utility	NOUN
admet-441	362	48	of	of	ADP
admet-441	362	49	a	a	DET
admet-441	362	50	physiologically	physiologically	ADV
admet-441	362	51	-	-	PUNCT
admet-441	362	52	based	base	VERB
admet-441	362	53	pharmacokinetic	pharmacokinetic	ADJ
admet-441	362	54	(	(	PUNCT
admet-441	362	55	pbpk	pbpk	NOUN
admet-441	362	56	)	)	PUNCT
admet-441	362	57	modeling	model	VERB
admet-441	362	58	approach	approach	NOUN
admet-441	362	59	to	to	PART
admet-441	362	60	quantitatively	quantitatively	ADV
admet-441	362	61	predict	predict	VERB
admet-441	362	62	a	a	DET
admet-441	362	63	complex	complex	ADJ
admet-441	362	64	drug	drug	NOUN
admet-441	362	65	-	-	PUNCT
admet-441	362	66	drug	drug	NOUN
admet-441	362	67	-	-	PUNCT
admet-441	362	68	disease	disease	NOUN
admet-441	362	69	interaction	interaction	NOUN
admet-441	362	70	scenario	scenario	NOUN
admet-441	362	71	for	for	ADP
admet-441	362	72	rivaroxaban	rivaroxaban	NOUN
admet-441	362	73	during	during	ADP
admet-441	362	74	the	the	DET
admet-441	362	75	drug	drug	NOUN
admet-441	362	76	review	review	NOUN
admet-441	362	77	process	process	NOUN
admet-441	362	78	:	:	PUNCT
admet-441	362	79	implications	implication	NOUN
admet-441	362	80	for	for	ADP
admet-441	362	81	clinical	clinical	ADJ
admet-441	362	82	practice	practice	NOUN
admet-441	362	83	.	.	PUNCT
admet-441	363	1	biopharm	biopharm	NOUN
admet-441	363	2	drug	drug	NOUN
admet-441	363	3	dispos	dispos	PROPN
admet-441	363	4	33	33	NUM
admet-441	363	5	(	(	PUNCT
admet-441	363	6	2012	2012	NUM
admet-441	363	7	)	)	PUNCT
admet-441	363	8	99	99	NUM
admet-441	363	9	-	-	SYM
admet-441	363	10	110	110	NUM
admet-441	363	11	.	.	PUNCT
admet-441	364	1	©	©	PROPN
admet-441	364	2	2017	2017	NUM
admet-441	364	3	by	by	ADP
admet-441	364	4	the	the	DET
admet-441	364	5	authors	author	NOUN
admet-441	364	6	;	;	PUNCT
admet-441	364	7	licensee	licensee	PROPN
admet-441	364	8	iapc	iapc	PROPN
admet-441	364	9	,	,	PUNCT
admet-441	364	10	zagreb	zagreb	PROPN
admet-441	364	11	,	,	PUNCT
admet-441	364	12	croatia	croatia	PROPN
admet-441	364	13	.	.	PUNCT
admet-441	365	1	this	this	DET
admet-441	365	2	article	article	NOUN
admet-441	365	3	is	be	AUX
admet-441	365	4	an	an	DET
admet-441	365	5	open	open	ADJ
admet-441	365	6	-	-	PUNCT
admet-441	365	7	access	access	NOUN
admet-441	365	8	article	article	NOUN
admet-441	365	9	distributed	distribute	VERB
admet-441	365	10	under	under	ADP
admet-441	365	11	the	the	DET
admet-441	365	12	terms	term	NOUN
admet-441	365	13	and	and	CCONJ
admet-441	365	14	conditions	condition	NOUN
admet-441	365	15	of	of	ADP
admet-441	365	16	the	the	DET
admet-441	365	17	creative	creative	ADJ
admet-441	365	18	commons	common	NOUN
admet-441	365	19	attribution	attribution	NOUN
admet-441	365	20	license	license	NOUN
admet-441	365	21	(	(	PUNCT
admet-441	365	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-441	365	23	)	)	PUNCT
admet-441	365	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN