id	sid	tid	token	lemma	pos
admet-470	1	1	in	in	ADP
admet-470	1	2	silico	silico	NOUN
admet-470	1	3	adme	adme	NOUN
admet-470	1	4	in	in	ADP
admet-470	1	5	drug	drug	NOUN
admet-470	1	6	design	design	NOUN
admet-470	1	7	–	–	PUNCT
admet-470	1	8	enhancing	enhance	VERB
admet-470	1	9	the	the	DET
admet-470	1	10	impact	impact	NOUN
admet-470	1	11	doi	doi	NOUN
admet-470	1	12	:	:	PUNCT
admet-470	1	13	10.5599	10.5599	NUM
admet-470	1	14	/	/	SYM
admet-470	1	15	admet.6.1.470	admet.6.1.470	PROPN
admet-470	1	16	15	15	NUM
admet-470	1	17	admet	admet	X
admet-470	1	18	&	&	CCONJ
admet-470	1	19	dmpk	dmpk	PROPN
admet-470	1	20	6(1	6(1	NUM
admet-470	1	21	)	)	PUNCT
admet-470	1	22	(	(	PUNCT
admet-470	1	23	2018	2018	NUM
admet-470	1	24	)	)	PUNCT
admet-470	1	25	15	15	NUM
admet-470	1	26	-	-	SYM
admet-470	1	27	33	33	NUM
admet-470	1	28	;	;	PUNCT
admet-470	1	29	doi	doi	NOUN
admet-470	1	30	:	:	PUNCT
admet-470	1	31	http://dx.doi.org/10.5599/admet.6.1.470	http://dx.doi.org/10.5599/admet.6.1.470	ADP
admet-470	1	32	open	open	ADJ
admet-470	1	33	access	access	NOUN
admet-470	1	34	:	:	PUNCT
admet-470	1	35	issn	issn	PROPN
admet-470	1	36	:	:	PUNCT
admet-470	1	37	1848	1848	NUM
admet-470	1	38	-	-	SYM
admet-470	1	39	7718	7718	NUM
admet-470	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-470	1	41	original	original	ADJ
admet-470	1	42	scientific	scientific	ADJ
admet-470	1	43	paper	paper	NOUN
admet-470	1	44	in	in	ADP
admet-470	1	45	silico	silico	NOUN
admet-470	1	46	adme	adme	NOUN
admet-470	1	47	in	in	ADP
admet-470	1	48	drug	drug	NOUN
admet-470	1	49	design	design	NOUN
admet-470	1	50	–	–	PUNCT
admet-470	1	51	enhancing	enhance	VERB
admet-470	1	52	the	the	DET
admet-470	1	53	impact	impact	NOUN
admet-470	1	54	susanne	susanne	PROPN
admet-470	1	55	winiwarter1	winiwarter1	PROPN
admet-470	1	56	,	,	PUNCT
admet-470	1	57	*	*	PROPN
admet-470	1	58	,	,	PUNCT
admet-470	1	59	ernst	ernst	PROPN
admet-470	1	60	ahlberg1	ahlberg1	PROPN
admet-470	1	61	,	,	PUNCT
admet-470	1	62	edmund	edmund	PROPN
admet-470	1	63	watson1	watson1	PROPN
admet-470	1	64	,	,	PUNCT
admet-470	1	65	ioana	ioana	PROPN
admet-470	1	66	oprisiu1	oprisiu1	PROPN
admet-470	1	67	,	,	PUNCT
admet-470	1	68	mickael	mickael	PROPN
admet-470	1	69	mogemark1	mogemark1	PROPN
admet-470	1	70	,	,	PUNCT
admet-470	1	71	tobias	tobias	PROPN
admet-470	1	72	noeske1	noeske1	PROPN
admet-470	1	73	,	,	PUNCT
admet-470	1	74	nigel	nigel	PROPN
admet-470	1	75	greene2	greene2	PROPN
admet-470	1	76	1	1	NUM
admet-470	1	77	drug	drug	NOUN
admet-470	1	78	safety	safety	NOUN
admet-470	1	79	and	and	CCONJ
admet-470	1	80	metabolism	metabolism	NOUN
admet-470	1	81	,	,	PUNCT
admet-470	1	82	imed	imed	PROPN
admet-470	1	83	biotech	biotech	PROPN
admet-470	1	84	unit	unit	NOUN
admet-470	1	85	,	,	PUNCT
admet-470	1	86	astrazeneca	astrazeneca	PROPN
admet-470	1	87	,	,	PUNCT
admet-470	1	88	gothenburg	gothenburg	PROPN
admet-470	1	89	,	,	PUNCT
admet-470	1	90	sweden	sweden	PROPN
admet-470	1	91	2	2	NUM
admet-470	1	92	drug	drug	NOUN
admet-470	1	93	safety	safety	NOUN
admet-470	1	94	and	and	CCONJ
admet-470	1	95	metabolism	metabolism	NOUN
admet-470	1	96	,	,	PUNCT
admet-470	1	97	imed	imed	PROPN
admet-470	1	98	biotech	biotech	PROPN
admet-470	1	99	unit	unit	NOUN
admet-470	1	100	,	,	PUNCT
admet-470	1	101	astrazeneca	astrazeneca	PROPN
admet-470	1	102	,	,	PUNCT
admet-470	1	103	boston	boston	PROPN
admet-470	1	104	,	,	PUNCT
admet-470	1	105	us	we	PRON
admet-470	1	106	*	*	PUNCT
admet-470	1	107	corresponding	correspond	VERB
admet-470	1	108	author	author	NOUN
admet-470	1	109	:	:	PUNCT
admet-470	1	110	e	e	NOUN
admet-470	1	111	-	-	NOUN
admet-470	1	112	mail	mail	NOUN
admet-470	1	113	:	:	PUNCT
admet-470	1	114	susanne.winiwarter@astrazeneca.net	susanne.winiwarter@astrazeneca.net	NOUN
admet-470	1	115	received	receive	VERB
admet-470	1	116	:	:	PUNCT
admet-470	1	117	november	november	PROPN
admet-470	1	118	08	08	NUM
admet-470	1	119	,	,	PUNCT
admet-470	1	120	2017	2017	NUM
admet-470	1	121	;	;	PUNCT
admet-470	1	122	revised	revise	VERB
admet-470	1	123	:	:	PUNCT
admet-470	1	124	december	december	PROPN
admet-470	1	125	12	12	NUM
admet-470	1	126	,	,	PUNCT
admet-470	1	127	2017	2017	NUM
admet-470	1	128	;	;	PUNCT
admet-470	1	129	published	publish	VERB
admet-470	1	130	:	:	PUNCT
admet-470	1	131	march	march	PROPN
admet-470	1	132	25	25	NUM
admet-470	1	133	,	,	PUNCT
admet-470	1	134	2018	2018	NUM
admet-470	1	135	abstract	abstract	NOUN
admet-470	1	136	each	each	DET
admet-470	1	137	year	year	NOUN
admet-470	1	138	the	the	DET
admet-470	1	139	pharmaceutical	pharmaceutical	NOUN
admet-470	1	140	industry	industry	NOUN
admet-470	1	141	makes	make	VERB
admet-470	1	142	thousands	thousand	NOUN
admet-470	1	143	of	of	ADP
admet-470	1	144	compounds	compound	NOUN
admet-470	1	145	,	,	PUNCT
admet-470	1	146	many	many	ADJ
admet-470	1	147	of	of	ADP
admet-470	1	148	which	which	PRON
admet-470	1	149	do	do	AUX
admet-470	1	150	not	not	PART
admet-470	1	151	meet	meet	VERB
admet-470	1	152	the	the	DET
admet-470	1	153	desired	desire	VERB
admet-470	1	154	efficacy	efficacy	NOUN
admet-470	1	155	or	or	CCONJ
admet-470	1	156	pharmacokinetic	pharmacokinetic	ADJ
admet-470	1	157	properties	property	NOUN
admet-470	1	158	,	,	PUNCT
admet-470	1	159	describing	describe	VERB
admet-470	1	160	the	the	DET
admet-470	1	161	absorption	absorption	NOUN
admet-470	1	162	,	,	PUNCT
admet-470	1	163	distribution	distribution	NOUN
admet-470	1	164	,	,	PUNCT
admet-470	1	165	metabolism	metabolism	NOUN
admet-470	1	166	and	and	CCONJ
admet-470	1	167	excretion	excretion	NOUN
admet-470	1	168	(	(	PUNCT
admet-470	1	169	adme	adme	NOUN
admet-470	1	170	)	)	PUNCT
admet-470	1	171	behavior	behavior	NOUN
admet-470	1	172	.	.	PUNCT
admet-470	2	1	parameters	parameter	NOUN
admet-470	2	2	such	such	ADJ
admet-470	2	3	as	as	ADP
admet-470	2	4	lipophilicity	lipophilicity	NOUN
admet-470	2	5	,	,	PUNCT
admet-470	2	6	solubility	solubility	NOUN
admet-470	2	7	and	and	CCONJ
admet-470	2	8	metabolic	metabolic	NOUN
admet-470	2	9	stability	stability	NOUN
admet-470	2	10	can	can	AUX
admet-470	2	11	be	be	AUX
admet-470	2	12	measured	measure	VERB
admet-470	2	13	in	in	ADP
admet-470	2	14	high	high	ADJ
admet-470	2	15	throughput	throughput	NOUN
admet-470	2	16	in	in	ADP
admet-470	2	17	vitro	vitro	X
admet-470	2	18	assays	assay	NOUN
admet-470	2	19	.	.	PUNCT
admet-470	3	1	however	however	ADV
admet-470	3	2	,	,	PUNCT
admet-470	3	3	a	a	DET
admet-470	3	4	compound	compound	NOUN
admet-470	3	5	needs	need	VERB
admet-470	3	6	to	to	PART
admet-470	3	7	be	be	AUX
admet-470	3	8	synthesized	synthesize	VERB
admet-470	3	9	in	in	ADP
admet-470	3	10	order	order	NOUN
admet-470	3	11	to	to	PART
admet-470	3	12	be	be	AUX
admet-470	3	13	tested	test	VERB
admet-470	3	14	.	.	PUNCT
admet-470	4	1	in	in	ADP
admet-470	4	2	silico	silico	NOUN
admet-470	4	3	models	model	NOUN
admet-470	4	4	for	for	ADP
admet-470	4	5	these	these	DET
admet-470	4	6	endpoints	endpoint	NOUN
admet-470	4	7	exist	exist	VERB
admet-470	4	8	,	,	PUNCT
admet-470	4	9	although	although	SCONJ
admet-470	4	10	with	with	ADP
admet-470	4	11	varying	vary	VERB
admet-470	4	12	quality	quality	NOUN
admet-470	4	13	.	.	PUNCT
admet-470	5	1	such	such	ADJ
admet-470	5	2	models	model	NOUN
admet-470	5	3	can	can	AUX
admet-470	5	4	be	be	AUX
admet-470	5	5	used	use	VERB
admet-470	5	6	before	before	ADP
admet-470	5	7	synthesis	synthesis	NOUN
admet-470	5	8	and	and	CCONJ
admet-470	5	9	,	,	PUNCT
admet-470	5	10	together	together	ADV
admet-470	5	11	with	with	ADP
admet-470	5	12	a	a	DET
admet-470	5	13	potency	potency	NOUN
admet-470	5	14	estimation	estimation	NOUN
admet-470	5	15	,	,	PUNCT
admet-470	5	16	influence	influence	VERB
admet-470	5	17	the	the	DET
admet-470	5	18	decision	decision	NOUN
admet-470	5	19	to	to	PART
admet-470	5	20	make	make	VERB
admet-470	5	21	a	a	DET
admet-470	5	22	compound	compound	NOUN
admet-470	5	23	.	.	PUNCT
admet-470	6	1	in	in	ADP
admet-470	6	2	practice	practice	NOUN
admet-470	6	3	,	,	PUNCT
admet-470	6	4	it	it	PRON
admet-470	6	5	appears	appear	VERB
admet-470	6	6	that	that	SCONJ
admet-470	6	7	often	often	ADV
admet-470	6	8	only	only	ADV
admet-470	6	9	one	one	NUM
admet-470	6	10	or	or	CCONJ
admet-470	6	11	two	two	NUM
admet-470	6	12	predicted	predict	VERB
admet-470	6	13	properties	property	NOUN
admet-470	6	14	are	be	AUX
admet-470	6	15	considered	consider	VERB
admet-470	6	16	prior	prior	ADV
admet-470	6	17	to	to	ADP
admet-470	6	18	synthesis	synthesis	NOUN
admet-470	6	19	,	,	PUNCT
admet-470	6	20	usually	usually	ADV
admet-470	6	21	including	include	VERB
admet-470	6	22	a	a	DET
admet-470	6	23	prediction	prediction	NOUN
admet-470	6	24	of	of	ADP
admet-470	6	25	lipophilicity	lipophilicity	NOUN
admet-470	6	26	.	.	PUNCT
admet-470	7	1	while	while	SCONJ
admet-470	7	2	it	it	PRON
admet-470	7	3	is	be	AUX
admet-470	7	4	important	important	ADJ
admet-470	7	5	to	to	PART
admet-470	7	6	use	use	VERB
admet-470	7	7	all	all	DET
admet-470	7	8	information	information	NOUN
admet-470	7	9	when	when	SCONJ
admet-470	7	10	deciding	decide	VERB
admet-470	7	11	which	which	DET
admet-470	7	12	compound	compound	NOUN
admet-470	7	13	to	to	PART
admet-470	7	14	make	make	VERB
admet-470	7	15	,	,	PUNCT
admet-470	7	16	it	it	PRON
admet-470	7	17	is	be	AUX
admet-470	7	18	somewhat	somewhat	ADV
admet-470	7	19	challenging	challenging	ADJ
admet-470	7	20	to	to	PART
admet-470	7	21	combine	combine	VERB
admet-470	7	22	multiple	multiple	ADJ
admet-470	7	23	predictions	prediction	NOUN
admet-470	7	24	unambiguously	unambiguously	ADV
admet-470	7	25	.	.	PUNCT
admet-470	8	1	this	this	DET
admet-470	8	2	work	work	NOUN
admet-470	8	3	investigates	investigate	VERB
admet-470	8	4	the	the	DET
admet-470	8	5	possibility	possibility	NOUN
admet-470	8	6	of	of	ADP
admet-470	8	7	combining	combine	VERB
admet-470	8	8	in	in	ADP
admet-470	8	9	silico	silico	NOUN
admet-470	8	10	adme	adme	NOUN
admet-470	8	11	predictions	prediction	NOUN
admet-470	8	12	to	to	PART
admet-470	8	13	define	define	VERB
admet-470	8	14	the	the	DET
admet-470	8	15	minimum	minimum	ADJ
admet-470	8	16	required	require	VERB
admet-470	8	17	potency	potency	NOUN
admet-470	8	18	for	for	ADP
admet-470	8	19	a	a	DET
admet-470	8	20	specified	specified	ADJ
admet-470	8	21	human	human	ADJ
admet-470	8	22	dose	dose	NOUN
admet-470	8	23	with	with	ADP
admet-470	8	24	sufficient	sufficient	ADJ
admet-470	8	25	confidence	confidence	NOUN
admet-470	8	26	.	.	PUNCT
admet-470	9	1	using	use	VERB
admet-470	9	2	a	a	DET
admet-470	9	3	set	set	NOUN
admet-470	9	4	of	of	ADP
admet-470	9	5	drug	drug	NOUN
admet-470	9	6	discovery	discovery	NOUN
admet-470	9	7	compounds	compound	NOUN
admet-470	9	8	,	,	PUNCT
admet-470	9	9	in	in	ADP
admet-470	9	10	silico	silico	NOUN
admet-470	9	11	predictions	prediction	NOUN
admet-470	9	12	were	be	AUX
admet-470	9	13	utilized	utilize	VERB
admet-470	9	14	to	to	PART
admet-470	9	15	compare	compare	VERB
admet-470	9	16	the	the	DET
admet-470	9	17	relative	relative	ADJ
admet-470	9	18	ranking	ranking	NOUN
admet-470	9	19	based	base	VERB
admet-470	9	20	on	on	ADP
admet-470	9	21	minimum	minimum	ADJ
admet-470	9	22	potency	potency	NOUN
admet-470	9	23	calculation	calculation	NOUN
admet-470	9	24	with	with	ADP
admet-470	9	25	the	the	DET
admet-470	9	26	outcomes	outcome	NOUN
admet-470	9	27	from	from	ADP
admet-470	9	28	the	the	DET
admet-470	9	29	selection	selection	NOUN
admet-470	9	30	of	of	ADP
admet-470	9	31	lead	lead	ADJ
admet-470	9	32	compounds	compound	NOUN
admet-470	9	33	.	.	PUNCT
admet-470	10	1	the	the	DET
admet-470	10	2	approach	approach	NOUN
admet-470	10	3	was	be	AUX
admet-470	10	4	also	also	ADV
admet-470	10	5	tested	test	VERB
admet-470	10	6	on	on	ADP
admet-470	10	7	a	a	DET
admet-470	10	8	set	set	NOUN
admet-470	10	9	of	of	ADP
admet-470	10	10	marketed	market	VERB
admet-470	10	11	drugs	drug	NOUN
admet-470	10	12	and	and	CCONJ
admet-470	10	13	the	the	DET
admet-470	10	14	influence	influence	NOUN
admet-470	10	15	of	of	ADP
admet-470	10	16	the	the	DET
admet-470	10	17	input	input	NOUN
admet-470	10	18	parameters	parameter	NOUN
admet-470	10	19	investigated	investigate	VERB
admet-470	10	20	.	.	PUNCT
admet-470	11	1	keywords	keyword	VERB
admet-470	11	2	drug	drug	NOUN
admet-470	11	3	discovery	discovery	NOUN
admet-470	11	4	;	;	PUNCT
admet-470	11	5	pharmacokinetics	pharmacokinetic	NOUN
admet-470	11	6	;	;	PUNCT
admet-470	11	7	in	in	ADP
admet-470	11	8	silico	silico	NOUN
admet-470	11	9	predictions	prediction	NOUN
admet-470	11	10	;	;	PUNCT
admet-470	11	11	multi	multi	ADJ
admet-470	11	12	-	-	ADJ
admet-470	11	13	parameter	parameter	ADJ
admet-470	11	14	ranking	ranking	NOUN
admet-470	11	15	introduction	introduction	NOUN
admet-470	11	16	drug	drug	NOUN
admet-470	11	17	design	design	NOUN
admet-470	11	18	is	be	AUX
admet-470	11	19	a	a	DET
admet-470	11	20	multi	multi	ADJ
admet-470	11	21	-	-	ADJ
admet-470	11	22	parameter	parameter	ADJ
admet-470	11	23	optimization	optimization	NOUN
admet-470	11	24	process	process	NOUN
admet-470	11	25	,	,	PUNCT
admet-470	11	26	with	with	ADP
admet-470	11	27	pharmacokinetic	pharmacokinetic	ADJ
admet-470	11	28	properties	property	NOUN
admet-470	11	29	describing	describe	VERB
admet-470	11	30	absorption	absorption	NOUN
admet-470	11	31	,	,	PUNCT
admet-470	11	32	distribution	distribution	NOUN
admet-470	11	33	,	,	PUNCT
admet-470	11	34	metabolism	metabolism	NOUN
admet-470	11	35	and	and	CCONJ
admet-470	11	36	excretion	excretion	NOUN
admet-470	11	37	(	(	PUNCT
admet-470	11	38	adme	adme	NOUN
admet-470	11	39	)	)	PUNCT
admet-470	11	40	of	of	ADP
admet-470	11	41	a	a	DET
admet-470	11	42	compound	compound	NOUN
admet-470	11	43	being	be	AUX
admet-470	11	44	important	important	ADJ
admet-470	11	45	to	to	PART
admet-470	11	46	consider	consider	VERB
admet-470	11	47	early	early	ADV
admet-470	11	48	on	on	ADV
admet-470	11	49	.	.	PUNCT
admet-470	12	1	these	these	DET
admet-470	12	2	parameters	parameter	NOUN
admet-470	12	3	describe	describe	VERB
admet-470	12	4	the	the	DET
admet-470	12	5	pharmacokinetics	pharmacokinetic	NOUN
admet-470	12	6	of	of	ADP
admet-470	12	7	a	a	DET
admet-470	12	8	compound	compound	NOUN
admet-470	12	9	and	and	CCONJ
admet-470	12	10	are	be	AUX
admet-470	12	11	key	key	ADJ
admet-470	12	12	to	to	ADP
admet-470	12	13	determining	determine	VERB
admet-470	12	14	the	the	DET
admet-470	12	15	dose	dose	NOUN
admet-470	12	16	required	require	VERB
admet-470	12	17	for	for	ADP
admet-470	12	18	efficacy	efficacy	NOUN
admet-470	12	19	.	.	PUNCT
admet-470	13	1	parameters	parameter	NOUN
admet-470	13	2	such	such	ADJ
admet-470	13	3	as	as	ADP
admet-470	13	4	lipophilicity	lipophilicity	NOUN
admet-470	13	5	,	,	PUNCT
admet-470	13	6	solubility	solubility	NOUN
admet-470	13	7	,	,	PUNCT
admet-470	13	8	and	and	CCONJ
admet-470	13	9	metabolic	metabolic	NOUN
admet-470	13	10	stability	stability	NOUN
admet-470	13	11	can	can	AUX
admet-470	13	12	be	be	AUX
admet-470	13	13	measured	measure	VERB
admet-470	13	14	in	in	ADP
admet-470	13	15	a	a	DET
admet-470	13	16	high	high	ADJ
admet-470	13	17	throughput	throughput	NOUN
admet-470	13	18	manner	manner	NOUN
admet-470	13	19	in	in	ADP
admet-470	13	20	vitro	vitro	X
admet-470	13	21	and	and	CCONJ
admet-470	13	22	are	be	AUX
admet-470	13	23	,	,	PUNCT
admet-470	13	24	thus	thus	ADV
admet-470	13	25	,	,	PUNCT
admet-470	13	26	often	often	ADV
admet-470	13	27	used	use	VERB
admet-470	13	28	as	as	ADP
admet-470	13	29	early	early	ADJ
admet-470	13	30	adme	adme	NOUN
admet-470	13	31	screens	screen	NOUN
admet-470	13	32	.	.	PUNCT
admet-470	14	1	during	during	ADP
admet-470	14	2	lead	lead	NOUN
admet-470	14	3	identification	identification	NOUN
admet-470	14	4	and	and	CCONJ
admet-470	14	5	lead	lead	VERB
admet-470	14	6	optimization	optimization	NOUN
admet-470	14	7	phases	phase	NOUN
admet-470	14	8	a	a	DET
admet-470	14	9	substantial	substantial	ADJ
admet-470	14	10	number	number	NOUN
admet-470	14	11	of	of	ADP
admet-470	14	12	compounds	compound	NOUN
admet-470	14	13	is	be	AUX
admet-470	14	14	synthesized	synthesize	VERB
admet-470	14	15	and	and	CCONJ
admet-470	14	16	characterized	characterize	VERB
admet-470	14	17	in	in	ADP
admet-470	14	18	such	such	ADJ
admet-470	14	19	screening	screening	NOUN
admet-470	14	20	assays	assay	NOUN
admet-470	14	21	for	for	ADP
admet-470	14	22	selection	selection	NOUN
admet-470	14	23	towards	towards	ADP
admet-470	14	24	additional	additional	ADJ
admet-470	14	25	,	,	PUNCT
admet-470	14	26	more	more	ADV
admet-470	14	27	costly	costly	ADJ
admet-470	14	28	in	in	ADP
admet-470	14	29	vitro	vitro	X
admet-470	14	30	and	and	CCONJ
admet-470	14	31	in	in	ADP
admet-470	14	32	vivo	vivo	ADJ
admet-470	14	33	experiments	experiment	NOUN
admet-470	14	34	to	to	PART
admet-470	14	35	be	be	AUX
admet-470	14	36	able	able	ADJ
admet-470	14	37	to	to	PART
admet-470	14	38	finally	finally	ADV
admet-470	14	39	select	select	VERB
admet-470	14	40	a	a	DET
admet-470	14	41	single	single	ADJ
admet-470	14	42	candidate	candidate	NOUN
admet-470	14	43	drug	drug	NOUN
admet-470	14	44	.	.	PUNCT
admet-470	15	1	however	however	ADV
admet-470	15	2	,	,	PUNCT
admet-470	15	3	a	a	DET
admet-470	15	4	compound	compound	NOUN
admet-470	15	5	needs	need	VERB
admet-470	15	6	to	to	PART
admet-470	15	7	be	be	AUX
admet-470	15	8	physically	physically	ADV
admet-470	15	9	available	available	ADJ
admet-470	15	10	to	to	PART
admet-470	15	11	be	be	AUX
admet-470	15	12	subjected	subject	VERB
admet-470	15	13	to	to	ADP
admet-470	15	14	such	such	ADJ
admet-470	15	15	assays	assay	NOUN
admet-470	15	16	.	.	PUNCT
admet-470	16	1	thus	thus	ADV
admet-470	16	2	,	,	PUNCT
admet-470	16	3	drug	drug	NOUN
admet-470	16	4	industry	industry	NOUN
admet-470	16	5	generates	generate	VERB
admet-470	16	6	thousands	thousand	NOUN
admet-470	16	7	of	of	ADP
admet-470	16	8	compounds	compound	NOUN
admet-470	16	9	per	per	ADP
admet-470	16	10	month	month	NOUN
admet-470	16	11	out	out	ADP
admet-470	16	12	of	of	ADP
admet-470	16	13	which	which	PRON
admet-470	16	14	many	many	ADJ
admet-470	16	15	do	do	AUX
admet-470	16	16	not	not	PART
admet-470	16	17	show	show	VERB
admet-470	16	18	desirable	desirable	ADJ
admet-470	16	19	adme	adme	NOUN
admet-470	16	20	properties	property	NOUN
admet-470	16	21	.	.	PUNCT
admet-470	17	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-470	17	2	susanne	susanne	PROPN
admet-470	17	3	winiwarter	winiwarter	PROPN
admet-470	17	4	et	et	PROPN
admet-470	17	5	al	al	PROPN
admet-470	17	6	.	.	PROPN
admet-470	17	7	admet	admet	PROPN
admet-470	17	8	&	&	CCONJ
admet-470	17	9	dmpk	dmpk	PROPN
admet-470	17	10	6(1	6(1	NUM
admet-470	17	11	)	)	PUNCT
admet-470	17	12	(	(	PUNCT
admet-470	17	13	2018	2018	NUM
admet-470	17	14	)	)	PUNCT
admet-470	17	15	15	15	NUM
admet-470	17	16	-	-	SYM
admet-470	17	17	33	33	NUM
admet-470	17	18	16	16	NUM
admet-470	17	19	in	in	ADP
admet-470	17	20	silico	silico	NOUN
admet-470	17	21	models	model	NOUN
admet-470	17	22	for	for	ADP
admet-470	17	23	such	such	ADJ
admet-470	17	24	adme	adme	NOUN
admet-470	17	25	endpoints	endpoint	NOUN
admet-470	17	26	,	,	PUNCT
admet-470	17	27	on	on	ADP
admet-470	17	28	the	the	DET
admet-470	17	29	other	other	ADJ
admet-470	17	30	hand	hand	NOUN
admet-470	17	31	,	,	PUNCT
admet-470	17	32	have	have	AUX
admet-470	17	33	been	be	AUX
admet-470	17	34	available	available	ADJ
admet-470	17	35	for	for	ADP
admet-470	17	36	a	a	DET
admet-470	17	37	long	long	ADJ
admet-470	17	38	time	time	NOUN
admet-470	17	39	,	,	PUNCT
admet-470	17	40	though	though	SCONJ
admet-470	17	41	with	with	ADP
admet-470	17	42	varying	vary	VERB
admet-470	17	43	quality	quality	NOUN
admet-470	17	44	and	and	CCONJ
admet-470	17	45	usability	usability	NOUN
admet-470	17	46	[	[	X
admet-470	17	47	1	1	NUM
admet-470	17	48	-	-	SYM
admet-470	17	49	6	6	NUM
admet-470	17	50	]	]	PUNCT
admet-470	17	51	.	.	PUNCT
admet-470	18	1	ideally	ideally	ADV
admet-470	18	2	,	,	PUNCT
admet-470	18	3	such	such	ADJ
admet-470	18	4	models	model	NOUN
admet-470	18	5	would	would	AUX
admet-470	18	6	be	be	AUX
admet-470	18	7	used	use	VERB
admet-470	18	8	before	before	ADP
admet-470	18	9	synthesis	synthesis	NOUN
admet-470	18	10	and	and	CCONJ
admet-470	18	11	,	,	PUNCT
admet-470	18	12	together	together	ADV
admet-470	18	13	with	with	ADP
admet-470	18	14	any	any	DET
admet-470	18	15	potency	potency	NOUN
admet-470	18	16	estimation	estimation	NOUN
admet-470	18	17	for	for	ADP
admet-470	18	18	the	the	DET
admet-470	18	19	specific	specific	ADJ
admet-470	18	20	case	case	NOUN
admet-470	18	21	,	,	PUNCT
admet-470	18	22	influence	influence	VERB
admet-470	18	23	the	the	DET
admet-470	18	24	decision	decision	NOUN
admet-470	18	25	to	to	PART
admet-470	18	26	make	make	VERB
admet-470	18	27	a	a	DET
admet-470	18	28	compound	compound	NOUN
admet-470	18	29	.	.	PUNCT
admet-470	19	1	consequent	consequent	ADJ
admet-470	19	2	usage	usage	NOUN
admet-470	19	3	of	of	ADP
admet-470	19	4	such	such	ADJ
admet-470	19	5	in	in	ADP
admet-470	19	6	silico	silico	NOUN
admet-470	19	7	predictions	prediction	NOUN
admet-470	19	8	has	have	VERB
admet-470	19	9	the	the	DET
admet-470	19	10	potential	potential	NOUN
admet-470	19	11	to	to	PART
admet-470	19	12	considerably	considerably	ADV
admet-470	19	13	reduce	reduce	VERB
admet-470	19	14	the	the	DET
admet-470	19	15	number	number	NOUN
admet-470	19	16	of	of	ADP
admet-470	19	17	synthesized	synthesize	VERB
admet-470	19	18	compounds	compound	NOUN
admet-470	19	19	with	with	ADP
admet-470	19	20	inadequate	inadequate	ADJ
admet-470	19	21	adme	adme	NOUN
admet-470	19	22	properties	property	NOUN
admet-470	19	23	.	.	PUNCT
admet-470	20	1	in	in	ADP
admet-470	20	2	practice	practice	NOUN
admet-470	20	3	,	,	PUNCT
admet-470	20	4	it	it	PRON
admet-470	20	5	seems	seem	VERB
admet-470	20	6	that	that	SCONJ
admet-470	20	7	most	most	ADV
admet-470	20	8	often	often	ADV
admet-470	20	9	only	only	ADV
admet-470	20	10	a	a	DET
admet-470	20	11	few	few	ADJ
admet-470	20	12	predicted	predict	VERB
admet-470	20	13	properties	property	NOUN
admet-470	20	14	are	be	AUX
admet-470	20	15	really	really	ADV
admet-470	20	16	considered	consider	VERB
admet-470	20	17	before	before	ADP
admet-470	20	18	synthesis	synthesis	NOUN
admet-470	20	19	,	,	PUNCT
admet-470	20	20	usually	usually	ADV
admet-470	20	21	including	include	VERB
admet-470	20	22	lipophilicity	lipophilicity	NOUN
admet-470	20	23	as	as	ADP
admet-470	20	24	important	important	ADJ
admet-470	20	25	parameter	parameter	NOUN
admet-470	20	26	.	.	PUNCT
admet-470	21	1	while	while	SCONJ
admet-470	21	2	it	it	PRON
admet-470	21	3	is	be	AUX
admet-470	21	4	understood	understand	VERB
admet-470	21	5	that	that	SCONJ
admet-470	21	6	all	all	DET
admet-470	21	7	available	available	ADJ
admet-470	21	8	knowledge	knowledge	NOUN
admet-470	21	9	should	should	AUX
admet-470	21	10	be	be	AUX
admet-470	21	11	used	use	VERB
admet-470	21	12	to	to	PART
admet-470	21	13	select	select	VERB
admet-470	21	14	which	which	DET
admet-470	21	15	compound	compound	NOUN
admet-470	21	16	to	to	PART
admet-470	21	17	make	make	VERB
admet-470	21	18	,	,	PUNCT
admet-470	21	19	it	it	PRON
admet-470	21	20	is	be	AUX
admet-470	21	21	not	not	PART
admet-470	21	22	easy	easy	ADJ
admet-470	21	23	to	to	PART
admet-470	21	24	define	define	VERB
admet-470	21	25	how	how	SCONJ
admet-470	21	26	the	the	DET
admet-470	21	27	outcome	outcome	NOUN
admet-470	21	28	of	of	ADP
admet-470	21	29	various	various	ADJ
admet-470	21	30	predictions	prediction	NOUN
admet-470	21	31	can	can	AUX
admet-470	21	32	be	be	AUX
admet-470	21	33	combined	combine	VERB
admet-470	21	34	unambiguously	unambiguously	ADV
admet-470	21	35	.	.	PUNCT
admet-470	22	1	lately	lately	ADV
admet-470	22	2	,	,	PUNCT
admet-470	22	3	the	the	DET
admet-470	22	4	use	use	NOUN
admet-470	22	5	of	of	ADP
admet-470	22	6	multi	multi	ADJ
admet-470	22	7	-	-	ADJ
admet-470	22	8	parameter	parameter	ADJ
admet-470	22	9	optimization	optimization	NOUN
admet-470	22	10	and	and	CCONJ
admet-470	22	11	scoring	scoring	NOUN
admet-470	22	12	tools	tool	NOUN
admet-470	22	13	has	have	AUX
admet-470	22	14	been	be	AUX
admet-470	22	15	proposed	propose	VERB
admet-470	22	16	and	and	CCONJ
admet-470	22	17	shown	show	VERB
admet-470	22	18	to	to	PART
admet-470	22	19	be	be	AUX
admet-470	22	20	of	of	ADP
admet-470	22	21	value	value	NOUN
admet-470	22	22	[	[	X
admet-470	22	23	7	7	NUM
admet-470	22	24	,	,	PUNCT
admet-470	22	25	8	8	NUM
admet-470	22	26	]	]	PUNCT
admet-470	22	27	.	.	PUNCT
admet-470	23	1	however	however	ADV
admet-470	23	2	,	,	PUNCT
admet-470	23	3	the	the	DET
admet-470	23	4	definition	definition	NOUN
admet-470	23	5	of	of	ADP
admet-470	23	6	the	the	DET
admet-470	23	7	scoring	scoring	NOUN
admet-470	23	8	functions	function	NOUN
admet-470	23	9	can	can	AUX
admet-470	23	10	be	be	AUX
admet-470	23	11	difficult	difficult	ADJ
admet-470	23	12	and	and	CCONJ
admet-470	23	13	may	may	AUX
admet-470	23	14	be	be	AUX
admet-470	23	15	a	a	DET
admet-470	23	16	bit	bit	NOUN
admet-470	23	17	arbitrary	arbitrary	ADJ
admet-470	23	18	.	.	PUNCT
admet-470	24	1	as	as	SCONJ
admet-470	24	2	physiologically	physiologically	ADV
admet-470	24	3	meaningful	meaningful	ADJ
admet-470	24	4	scoring	scoring	NOUN
admet-470	24	5	function	function	NOUN
admet-470	24	6	the	the	DET
admet-470	24	7	predicted	predict	VERB
admet-470	24	8	dose	dose	NOUN
admet-470	24	9	to	to	ADP
admet-470	24	10	man	man	NOUN
admet-470	24	11	(	(	PUNCT
admet-470	24	12	d2	d2	PROPN
admet-470	24	13	m	m	PROPN
admet-470	24	14	)	)	PUNCT
admet-470	24	15	has	have	AUX
admet-470	24	16	been	be	AUX
admet-470	24	17	suggested	suggest	VERB
admet-470	24	18	to	to	PART
admet-470	24	19	utilize	utilize	VERB
admet-470	24	20	as	as	ADV
admet-470	24	21	early	early	ADV
admet-470	24	22	as	as	ADP
admet-470	24	23	possible	possible	ADJ
admet-470	24	24	.	.	PUNCT
admet-470	25	1	several	several	ADJ
admet-470	25	2	reports	report	NOUN
admet-470	25	3	validated	validate	VERB
admet-470	25	4	early	early	ADJ
admet-470	25	5	d2	d2	PROPN
admet-470	25	6	m	m	NOUN
admet-470	25	7	predictions	prediction	NOUN
admet-470	25	8	both	both	CCONJ
admet-470	25	9	from	from	ADP
admet-470	25	10	preclinical	preclinical	NOUN
admet-470	25	11	in	in	ADP
admet-470	25	12	vivo	vivo	ADJ
admet-470	25	13	data	datum	NOUN
admet-470	25	14	[	[	X
admet-470	25	15	9	9	NUM
admet-470	25	16	]	]	PUNCT
admet-470	25	17	as	as	ADV
admet-470	25	18	well	well	ADV
admet-470	25	19	as	as	ADP
admet-470	25	20	from	from	ADP
admet-470	25	21	in	in	ADP
admet-470	25	22	vitro	vitro	X
admet-470	25	23	data	datum	NOUN
admet-470	25	24	combined	combine	VERB
admet-470	25	25	with	with	ADP
admet-470	25	26	in	in	ADP
admet-470	25	27	silico	silico	NOUN
admet-470	25	28	predictions	prediction	NOUN
admet-470	25	29	[	[	X
admet-470	25	30	10	10	NUM
admet-470	25	31	]	]	PUNCT
admet-470	25	32	.	.	PUNCT
admet-470	26	1	however	however	ADV
admet-470	26	2	,	,	PUNCT
admet-470	26	3	using	use	VERB
admet-470	26	4	in	in	ADP
admet-470	26	5	silico	silico	NOUN
admet-470	26	6	predictions	prediction	NOUN
admet-470	26	7	only	only	ADV
admet-470	26	8	was	be	AUX
admet-470	26	9	not	not	PART
admet-470	26	10	found	find	VERB
admet-470	26	11	to	to	PART
admet-470	26	12	be	be	AUX
admet-470	26	13	reliable	reliable	ADJ
admet-470	26	14	enough	enough	ADV
admet-470	26	15	,	,	PUNCT
admet-470	26	16	since	since	SCONJ
admet-470	26	17	both	both	DET
admet-470	26	18	potency	potency	NOUN
admet-470	26	19	and	and	CCONJ
admet-470	26	20	pharmacokinetic	pharmacokinetic	ADJ
admet-470	26	21	properties	property	NOUN
admet-470	26	22	would	would	AUX
admet-470	26	23	need	need	VERB
admet-470	26	24	to	to	PART
admet-470	26	25	be	be	AUX
admet-470	26	26	accurately	accurately	ADV
admet-470	26	27	predicted	predict	VERB
admet-470	26	28	.	.	PUNCT
admet-470	27	1	here	here	ADV
admet-470	27	2	we	we	PRON
admet-470	27	3	concentrate	concentrate	VERB
admet-470	27	4	on	on	ADP
admet-470	27	5	the	the	DET
admet-470	27	6	pharmacokinetic	pharmacokinetic	ADJ
admet-470	27	7	properties	property	NOUN
admet-470	27	8	only	only	ADV
admet-470	27	9	and	and	CCONJ
admet-470	27	10	suggest	suggest	VERB
admet-470	27	11	to	to	PART
admet-470	27	12	use	use	VERB
admet-470	27	13	in	in	ADP
admet-470	27	14	silico	silico	NOUN
admet-470	27	15	adme	adme	NOUN
admet-470	27	16	models	model	NOUN
admet-470	27	17	to	to	PART
admet-470	27	18	predict	predict	VERB
admet-470	27	19	what	what	DET
admet-470	27	20	potency	potency	NOUN
admet-470	27	21	would	would	AUX
admet-470	27	22	be	be	AUX
admet-470	27	23	required	require	VERB
admet-470	27	24	for	for	ADP
admet-470	27	25	a	a	DET
admet-470	27	26	specific	specific	ADJ
admet-470	27	27	compound	compound	NOUN
admet-470	27	28	to	to	PART
admet-470	27	29	enable	enable	VERB
admet-470	27	30	coverage	coverage	NOUN
admet-470	27	31	during	during	ADP
admet-470	27	32	the	the	DET
admet-470	27	33	whole	whole	ADJ
admet-470	27	34	dosing	dose	VERB
admet-470	27	35	interval	interval	NOUN
admet-470	27	36	.	.	PUNCT
admet-470	28	1	by	by	ADP
admet-470	28	2	reverting	revert	VERB
admet-470	28	3	the	the	DET
admet-470	28	4	d2	d2	PROPN
admet-470	28	5	m	m	NOUN
admet-470	28	6	equation	equation	NOUN
admet-470	28	7	and	and	CCONJ
admet-470	28	8	setting	set	VERB
admet-470	28	9	the	the	DET
admet-470	28	10	target	target	NOUN
admet-470	28	11	dose	dose	VERB
admet-470	28	12	to	to	ADP
admet-470	28	13	,	,	PUNCT
admet-470	28	14	for	for	ADP
admet-470	28	15	example	example	NOUN
admet-470	28	16	,	,	PUNCT
admet-470	28	17	100	100	NUM
admet-470	28	18	mg	mg	ADP
admet-470	28	19	once	once	ADV
admet-470	28	20	daily	daily	ADV
admet-470	28	21	,	,	PUNCT
admet-470	28	22	the	the	DET
admet-470	28	23	achievable	achievable	ADJ
admet-470	28	24	plasma	plasma	NOUN
admet-470	28	25	concentration	concentration	NOUN
admet-470	28	26	can	can	AUX
admet-470	28	27	be	be	AUX
admet-470	28	28	calculated	calculate	VERB
admet-470	28	29	from	from	ADP
admet-470	28	30	in	in	ADP
admet-470	28	31	silico	silico	NOUN
admet-470	28	32	predicted	predict	VERB
admet-470	28	33	parameters	parameter	NOUN
admet-470	28	34	and	and	CCONJ
admet-470	28	35	the	the	DET
admet-470	28	36	minimum	minimum	ADJ
admet-470	28	37	required	require	VERB
admet-470	28	38	potency	potency	NOUN
admet-470	28	39	(	(	PUNCT
admet-470	28	40	“	"	PUNCT
admet-470	28	41	threshold	threshold	NOUN
admet-470	28	42	pic50	pic50	NOUN
admet-470	28	43	”	"	PUNCT
admet-470	28	44	)	)	PUNCT
admet-470	28	45	defined	define	VERB
admet-470	28	46	as	as	ADP
admet-470	28	47	ranking	rank	VERB
admet-470	28	48	score	score	NOUN
admet-470	28	49	for	for	ADP
admet-470	28	50	virtual	virtual	ADJ
admet-470	28	51	compounds	compound	NOUN
admet-470	28	52	.	.	PUNCT
admet-470	29	1	we	we	PRON
admet-470	29	2	show	show	VERB
admet-470	29	3	how	how	SCONJ
admet-470	29	4	such	such	DET
admet-470	29	5	a	a	DET
admet-470	29	6	ranking	rank	VERB
admet-470	29	7	score	score	NOUN
admet-470	29	8	could	could	AUX
admet-470	29	9	be	be	AUX
admet-470	29	10	used	use	VERB
admet-470	29	11	in	in	ADP
admet-470	29	12	the	the	DET
admet-470	29	13	discovery	discovery	NOUN
admet-470	29	14	setting	set	VERB
admet-470	29	15	on	on	ADP
admet-470	29	16	the	the	DET
admet-470	29	17	example	example	NOUN
admet-470	29	18	of	of	ADP
admet-470	29	19	a	a	DET
admet-470	29	20	set	set	NOUN
admet-470	29	21	of	of	ADP
admet-470	29	22	27	27	NUM
admet-470	29	23	compounds	compound	NOUN
admet-470	29	24	leading	lead	VERB
admet-470	29	25	towards	towards	ADP
admet-470	29	26	a	a	DET
admet-470	29	27	candidate	candidate	NOUN
admet-470	29	28	structure	structure	NOUN
admet-470	30	1	[	[	X
admet-470	30	2	11	11	NUM
admet-470	30	3	]	]	PUNCT
admet-470	30	4	.	.	PUNCT
admet-470	31	1	we	we	PRON
admet-470	31	2	also	also	ADV
admet-470	31	3	test	test	VERB
admet-470	31	4	the	the	DET
admet-470	31	5	concept	concept	NOUN
admet-470	31	6	on	on	ADP
admet-470	31	7	a	a	DET
admet-470	31	8	set	set	NOUN
admet-470	31	9	of	of	ADP
admet-470	31	10	known	know	VERB
admet-470	31	11	drugs	drug	NOUN
admet-470	31	12	with	with	ADP
admet-470	31	13	information	information	NOUN
admet-470	31	14	about	about	ADP
admet-470	31	15	dosing	dosing	NOUN
admet-470	31	16	and	and	CCONJ
admet-470	31	17	human	human	ADJ
admet-470	31	18	pharmacokinetics	pharmacokinetic	NOUN
admet-470	31	19	[	[	X
admet-470	31	20	9	9	NUM
admet-470	31	21	]	]	PUNCT
admet-470	31	22	and	and	CCONJ
admet-470	31	23	compare	compare	VERB
admet-470	31	24	the	the	DET
admet-470	31	25	results	result	NOUN
admet-470	31	26	from	from	ADP
admet-470	31	27	purely	purely	ADV
admet-470	31	28	in	in	ADP
admet-470	31	29	silico	silico	NOUN
admet-470	31	30	predictions	prediction	NOUN
admet-470	31	31	to	to	ADP
admet-470	31	32	those	those	PRON
admet-470	31	33	from	from	ADP
admet-470	31	34	in	in	ADP
admet-470	31	35	vitro	vitro	X
admet-470	31	36	data	datum	NOUN
admet-470	31	37	and	and	CCONJ
admet-470	31	38	from	from	ADP
admet-470	31	39	human	human	NOUN
admet-470	31	40	in	in	ADP
admet-470	31	41	vivo	vivo	ADJ
admet-470	31	42	data	datum	NOUN
admet-470	31	43	.	.	PUNCT
admet-470	32	1	we	we	PRON
admet-470	32	2	also	also	ADV
admet-470	32	3	investigate	investigate	VERB
admet-470	32	4	how	how	SCONJ
admet-470	32	5	the	the	DET
admet-470	32	6	in	in	ADP
admet-470	32	7	silico	silico	NOUN
admet-470	32	8	derived	derive	VERB
admet-470	32	9	parameters	parameter	NOUN
admet-470	32	10	influence	influence	VERB
admet-470	32	11	the	the	DET
admet-470	32	12	outcome	outcome	NOUN
admet-470	32	13	of	of	ADP
admet-470	32	14	the	the	DET
admet-470	32	15	equations	equation	NOUN
admet-470	32	16	,	,	PUNCT
admet-470	32	17	highlighting	highlight	VERB
admet-470	32	18	concepts	concept	NOUN
admet-470	32	19	to	to	PART
admet-470	32	20	help	help	VERB
admet-470	32	21	drug	drug	NOUN
admet-470	32	22	discovery	discovery	NOUN
admet-470	32	23	to	to	PART
admet-470	32	24	improve	improve	VERB
admet-470	32	25	pharmacokinetic	pharmacokinetic	ADJ
admet-470	32	26	properties	property	NOUN
admet-470	32	27	during	during	ADP
admet-470	32	28	design	design	NOUN
admet-470	32	29	.	.	PUNCT
admet-470	33	1	experimental	experimental	ADJ
admet-470	33	2	inverse	inverse	NOUN
admet-470	33	3	dose	dose	PROPN
admet-470	33	4	-	-	PUNCT
admet-470	33	5	to	to	ADP
admet-470	33	6	-	-	PUNCT
admet-470	33	7	man	man	NOUN
admet-470	33	8	(	(	PUNCT
admet-470	33	9	d2	d2	PROPN
admet-470	33	10	m	m	NOUN
admet-470	33	11	)	)	PUNCT
admet-470	33	12	prediction	prediction	NOUN
admet-470	33	13	equations	equation	NOUN
admet-470	33	14	used	use	VERB
admet-470	33	15	are	be	AUX
admet-470	33	16	standard	standard	ADJ
admet-470	33	17	pharmacokinetic	pharmacokinetic	ADJ
admet-470	33	18	equations	equation	NOUN
admet-470	33	19	[	[	X
admet-470	33	20	9	9	NUM
admet-470	33	21	,	,	PUNCT
admet-470	33	22	12	12	NUM
admet-470	33	23	,	,	PUNCT
admet-470	33	24	13	13	NUM
admet-470	33	25	]	]	PUNCT
admet-470	33	26	based	base	VERB
admet-470	33	27	on	on	ADP
admet-470	33	28	a	a	DET
admet-470	33	29	one	one	NUM
admet-470	33	30	compartment	compartment	NOUN
admet-470	33	31	model	model	NOUN
admet-470	33	32	considering	consider	VERB
admet-470	33	33	immediate	immediate	ADJ
admet-470	33	34	absorption	absorption	NOUN
admet-470	33	35	to	to	PART
admet-470	33	36	estimate	estimate	VERB
admet-470	33	37	the	the	DET
admet-470	33	38	average	average	ADJ
admet-470	33	39	(	(	PUNCT
admet-470	33	40	cave	cave	NOUN
admet-470	33	41	,	,	PUNCT
admet-470	33	42	eq	eq	NOUN
admet-470	33	43	.	.	PROPN
admet-470	33	44	1	1	NUM
admet-470	33	45	)	)	PUNCT
admet-470	33	46	,	,	PUNCT
admet-470	33	47	minimum	minimum	NOUN
admet-470	33	48	(	(	PUNCT
admet-470	33	49	cmin	cmin	NOUN
admet-470	33	50	,	,	PUNCT
admet-470	33	51	eq	eq	NOUN
admet-470	33	52	.	.	NOUN
admet-470	33	53	2	2	NUM
admet-470	33	54	)	)	PUNCT
admet-470	33	55	and	and	CCONJ
admet-470	33	56	maximum	maximum	ADJ
admet-470	33	57	(	(	PUNCT
admet-470	33	58	cmax	cmax	NOUN
admet-470	33	59	,	,	PUNCT
admet-470	33	60	eq	eq	NOUN
admet-470	33	61	.	.	NOUN
admet-470	33	62	3	3	X
admet-470	33	63	)	)	PUNCT
admet-470	33	64	concentration	concentration	NOUN
admet-470	33	65	of	of	ADP
admet-470	33	66	a	a	DET
admet-470	33	67	drug	drug	NOUN
admet-470	33	68	at	at	ADP
admet-470	33	69	steady	steady	ADJ
admet-470	33	70	state	state	NOUN
admet-470	33	71	.	.	PUNCT
admet-470	34	1	(	(	PUNCT
admet-470	34	2	1	1	X
admet-470	34	3	)	)	PUNCT
admet-470	34	4	(	(	PUNCT
admet-470	34	5	2	2	NUM
admet-470	34	6	)	)	PUNCT
admet-470	34	7	(	(	PUNCT
admet-470	34	8	3	3	X
admet-470	34	9	)	)	PUNCT
admet-470	34	10	where	where	SCONJ
admet-470	34	11	f	f	PROPN
admet-470	34	12	is	be	AUX
admet-470	34	13	bioavailability	bioavailability	NOUN
admet-470	34	14	(	(	PUNCT
admet-470	34	15	eq	eq	NOUN
admet-470	34	16	.	.	NOUN
admet-470	34	17	4	4	NUM
admet-470	34	18	)	)	PUNCT
admet-470	34	19	,	,	PUNCT
admet-470	34	20	dpo	dpo	PROPN
admet-470	34	21	is	be	AUX
admet-470	34	22	the	the	DET
admet-470	34	23	daily	daily	ADJ
admet-470	34	24	oral	oral	ADJ
admet-470	34	25	dose	dose	NOUN
admet-470	34	26	,	,	PUNCT
admet-470	34	27	cl	cl	NOUN
admet-470	34	28	is	be	AUX
admet-470	34	29	the	the	DET
admet-470	34	30	plasma	plasma	NOUN
admet-470	34	31	clearance	clearance	NOUN
admet-470	34	32	estimated	estimate	VERB
admet-470	34	33	using	use	VERB
admet-470	34	34	the	the	DET
admet-470	34	35	well	well	ADV
admet-470	34	36	-	-	PUNCT
admet-470	34	37	stirred	stir	VERB
admet-470	34	38	model	model	NOUN
admet-470	34	39	(	(	PUNCT
admet-470	34	40	eq	eq	NOUN
admet-470	34	41	.	.	PROPN
admet-470	34	42	5	5	NUM
admet-470	34	43	)	)	PUNCT
admet-470	34	44	,	,	PUNCT
admet-470	34	45			PROPN
admet-470	34	46	is	be	AUX
admet-470	34	47	the	the	DET
admet-470	34	48	dosing	dosing	ADJ
admet-470	34	49	interval	interval	NOUN
admet-470	34	50	,	,	PUNCT
admet-470	34	51	typically	typically	ADV
admet-470	34	52	set	set	VERB
admet-470	34	53	to	to	ADP
admet-470	34	54	24	24	NUM
admet-470	34	55	h	h	NOUN
admet-470	34	56	,	,	PUNCT
admet-470	34	57	v	v	NOUN
admet-470	34	58	is	be	AUX
admet-470	34	59	the	the	DET
admet-470	34	60	volume	volume	NOUN
admet-470	34	61	of	of	ADP
admet-470	34	62	distribution	distribution	NOUN
admet-470	34	63	(	(	PUNCT
admet-470	34	64	predicted	predict	VERB
admet-470	34	65	)	)	PUNCT
admet-470	34	66	and	and	CCONJ
admet-470	34	67	ke	ke	PROPN
admet-470	34	68	is	be	AUX
admet-470	34	69	the	the	DET
admet-470	34	70	elimination	elimination	NOUN
admet-470	34	71	constant	constant	ADJ
admet-470	34	72	(	(	PUNCT
admet-470	34	73	eq	eq	NOUN
admet-470	34	74	.	.	PROPN
admet-470	34	75	6	6	NUM
admet-470	34	76	)	)	PUNCT
admet-470	34	77	.	.	PUNCT
admet-470	35	1	𝐹	𝐹	PROPN
admet-470	36	1	=	=	SYM
admet-470	36	2	𝐹abs	𝐹abs	PROPN
admet-470	36	3	∙	∙	PUNCT
admet-470	36	4	𝐹g	𝐹g	PROPN
admet-470	36	5	∙	∙	PROPN
admet-470	36	6	𝐹h	𝐹h	PROPN
admet-470	36	7	,	,	PUNCT
admet-470	36	8	(	(	PUNCT
admet-470	36	9	4	4	X
admet-470	36	10	)	)	PUNCT
admet-470	36	11	𝐶ave	𝐶ave	NOUN
admet-470	36	12	=	=	NOUN
admet-470	36	13	𝐹∙𝐷po∙	𝐹∙𝐷po∙	PUNCT
admet-470	36	14	𝜏	𝜏	PROPN
admet-470	36	15	24⁄	24⁄	NUM
admet-470	36	16	𝐶𝑙∙𝜏	𝐶𝑙∙𝜏	PROPN
admet-470	36	17	𝐶min	𝐶min	PROPN
admet-470	36	18	=	=	PUNCT
admet-470	36	19	𝐹∙𝐷po∙	𝐹∙𝐷po∙	PUNCT
admet-470	36	20	𝜏	𝜏	PROPN
admet-470	36	21	24⁄	24⁄	NUM
admet-470	36	22	𝑉∙(𝑒𝑘𝑒∙𝜏−1	𝑉∙(𝑒𝑘𝑒∙𝜏−1	NOUN
admet-470	36	23	)	)	PUNCT
admet-470	37	1	𝐶max	𝐶max	PROPN
admet-470	37	2	=	=	PUNCT
admet-470	37	3	𝐹∙𝐷po∙	𝐹∙𝐷po∙	PUNCT
admet-470	37	4	𝜏	𝜏	PROPN
admet-470	37	5	24⁄	24⁄	NUM
admet-470	37	6	𝑉∙(1−𝑒−𝑘𝑒∙𝜏	𝑉∙(1−𝑒−𝑘𝑒∙𝜏	NOUN
admet-470	37	7	)	)	PUNCT
admet-470	37	8	admet	admet	PROPN
admet-470	37	9	&	&	CCONJ
admet-470	37	10	dmpk	dmpk	PROPN
admet-470	37	11	6(1	6(1	NUM
admet-470	37	12	)	)	PUNCT
admet-470	37	13	(	(	PUNCT
admet-470	37	14	2018	2018	NUM
admet-470	37	15	)	)	PUNCT
admet-470	37	16	15	15	NUM
admet-470	37	17	-	-	SYM
admet-470	37	18	33	33	NUM
admet-470	37	19	in	in	ADP
admet-470	37	20	silico	silico	NOUN
admet-470	37	21	adme	adme	NOUN
admet-470	37	22	in	in	ADP
admet-470	37	23	drug	drug	NOUN
admet-470	37	24	design	design	NOUN
admet-470	37	25	doi	doi	NOUN
admet-470	37	26	:	:	PUNCT
admet-470	37	27	10.5599	10.5599	NUM
admet-470	37	28	/	/	SYM
admet-470	37	29	admet.6.1.470	admet.6.1.470	X
admet-470	37	30	17	17	NUM
admet-470	37	31	where	where	SCONJ
admet-470	37	32	fabs	fab	NOUN
admet-470	37	33	(	(	PUNCT
admet-470	37	34	fraction	fraction	NOUN
admet-470	37	35	absorbed	absorb	VERB
admet-470	37	36	)	)	PUNCT
admet-470	37	37	is	be	AUX
admet-470	37	38	estimated	estimate	VERB
admet-470	37	39	from	from	ADP
admet-470	37	40	permeability	permeability	NOUN
admet-470	37	41	(	(	PUNCT
admet-470	37	42	eq	eq	NOUN
admet-470	37	43	.	.	PROPN
admet-470	37	44	7	7	NUM
admet-470	37	45	)	)	PUNCT
admet-470	37	46	,	,	PUNCT
admet-470	37	47	fg	fg	PROPN
admet-470	37	48	(	(	PUNCT
admet-470	37	49	fraction	fraction	NOUN
admet-470	37	50	escaping	escape	VERB
admet-470	37	51	gut	gut	NOUN
admet-470	37	52	metabolism	metabolism	NOUN
admet-470	37	53	)	)	PUNCT
admet-470	37	54	is	be	AUX
admet-470	37	55	set	set	VERB
admet-470	37	56	to	to	ADP
admet-470	37	57	1	1	NUM
admet-470	37	58	and	and	CCONJ
admet-470	37	59	fh	fh	PROPN
admet-470	37	60	(	(	PUNCT
admet-470	37	61	fraction	fraction	NOUN
admet-470	37	62	escaping	escape	VERB
admet-470	37	63	hepatic	hepatic	ADJ
admet-470	37	64	metabolism	metabolism	NOUN
admet-470	37	65	)	)	PUNCT
admet-470	37	66	is	be	AUX
admet-470	37	67	estimated	estimate	VERB
admet-470	37	68	from	from	ADP
admet-470	37	69	cl	cl	NOUN
admet-470	37	70	(	(	PUNCT
admet-470	37	71	eq	eq	NOUN
admet-470	37	72	.	.	NOUN
admet-470	38	1	8)	8)	NUM
admet-470	38	2	.	.	PUNCT
admet-470	39	1	(	(	PUNCT
admet-470	39	2	5	5	NUM
admet-470	39	3	)	)	PUNCT
admet-470	39	4	with	with	ADP
admet-470	39	5	clb	clb	NOUN
admet-470	39	6	being	be	AUX
admet-470	39	7	blood	blood	NOUN
admet-470	39	8	clearance	clearance	NOUN
admet-470	39	9	,	,	PUNCT
admet-470	39	10	qh	qh	NOUN
admet-470	39	11	the	the	DET
admet-470	39	12	liver	liver	NOUN
admet-470	39	13	blood	blood	NOUN
admet-470	39	14	flow	flow	NOUN
admet-470	39	15	(	(	PUNCT
admet-470	39	16	20	20	NUM
admet-470	39	17	ml	ml	NOUN
admet-470	39	18	/	/	SYM
admet-470	39	19	min	min	NOUN
admet-470	39	20	/	/	SYM
admet-470	39	21	kg	kg	PROPN
admet-470	39	22	)	)	PUNCT
admet-470	39	23	,	,	PUNCT
admet-470	39	24	clintin	clintin	NOUN
admet-470	39	25	vivo	vivo	VERB
admet-470	39	26	the	the	PRON
admet-470	39	27	in	in	ADP
admet-470	39	28	vivo	vivo	ADJ
admet-470	39	29	intrinsic	intrinsic	ADJ
admet-470	39	30	clearance	clearance	NOUN
admet-470	39	31	estimated	estimate	VERB
admet-470	39	32	from	from	ADP
admet-470	39	33	in	in	ADP
admet-470	39	34	vitro	vitro	X
admet-470	39	35	clint	clint	NOUN
admet-470	39	36	(	(	PUNCT
admet-470	39	37	eq	eq	NOUN
admet-470	39	38	.	.	NOUN
admet-470	39	39	9	9	NUM
admet-470	39	40	)	)	PUNCT
admet-470	39	41	,	,	PUNCT
admet-470	39	42	and	and	CCONJ
admet-470	39	43	fub	fub	PROPN
admet-470	39	44	the	the	DET
admet-470	39	45	fraction	fraction	NOUN
admet-470	39	46	unbound	unbound	NOUN
admet-470	39	47	in	in	ADP
admet-470	39	48	blood	blood	NOUN
admet-470	39	49	.	.	PUNCT
admet-470	40	1	cl	cl	NOUN
admet-470	40	2	=	=	SYM
admet-470	40	3	clb	clb	NOUN
admet-470	40	4	∙	∙	PROPN
admet-470	40	5	𝑅b	𝑅b	NOUN
admet-470	40	6	,	,	PUNCT
admet-470	40	7	(	(	PUNCT
admet-470	40	8	5a	5a	NUM
admet-470	40	9	)	)	PUNCT
admet-470	40	10	where	where	SCONJ
admet-470	40	11	rb	rb	NOUN
admet-470	40	12	is	be	AUX
admet-470	40	13	the	the	DET
admet-470	40	14	blood	blood	NOUN
admet-470	40	15	plasma	plasma	NOUN
admet-470	40	16	ratio	ratio	NOUN
admet-470	40	17	and	and	CCONJ
admet-470	40	18	set	set	VERB
admet-470	40	19	to	to	ADP
admet-470	40	20	1	1	NUM
admet-470	40	21	for	for	ADP
admet-470	40	22	neutrals	neutral	NOUN
admet-470	40	23	and	and	CCONJ
admet-470	40	24	bases	basis	NOUN
admet-470	40	25	,	,	PUNCT
admet-470	40	26	whereas	whereas	SCONJ
admet-470	40	27	set	set	VERB
admet-470	40	28	to	to	ADP
admet-470	40	29	0.55	0.55	NUM
admet-470	40	30	for	for	ADP
admet-470	40	31	acids	acid	NOUN
admet-470	40	32	and	and	CCONJ
admet-470	40	33	zwitterions	zwitterions	PROPN
admet-470	40	34	.	.	PUNCT
admet-470	41	1	𝑓ub	𝑓ub	NOUN
admet-470	41	2	=	=	PUNCT
admet-470	42	1	𝑓u/𝑅b	𝑓u/𝑅b	NOUN
admet-470	42	2	,	,	PUNCT
admet-470	42	3	(	(	PUNCT
admet-470	42	4	5b	5b	NUM
admet-470	42	5	)	)	PUNCT
admet-470	42	6	where	where	SCONJ
admet-470	42	7	fu	fu	NOUN
admet-470	42	8	is	be	AUX
admet-470	42	9	fraction	fraction	NOUN
admet-470	42	10	unbound	unbound	NOUN
admet-470	42	11	in	in	ADP
admet-470	42	12	plasma	plasma	NOUN
admet-470	42	13	(	(	PUNCT
admet-470	42	14	predicted	predict	VERB
admet-470	42	15	)	)	PUNCT
admet-470	42	16	.	.	PUNCT
admet-470	43	1	𝑘e	𝑘e	PROPN
admet-470	44	1	=	=	NOUN
admet-470	44	2	cl/𝑉	cl/𝑉	ADJ
admet-470	44	3	(	(	PUNCT
admet-470	44	4	6	6	NUM
admet-470	44	5	)	)	PUNCT
admet-470	44	6	fabs	fab	NOUN
admet-470	44	7	=	=	SYM
admet-470	44	8	1	1	NUM
admet-470	44	9	,	,	PUNCT
admet-470	44	10	if	if	SCONJ
admet-470	44	11	papp	papp	NOUN
admet-470	44	12	>	>	X
admet-470	44	13	1	1	NUM
admet-470	44	14	x	x	SYM
admet-470	44	15	10	10	NUM
admet-470	44	16	-	-	SYM
admet-470	44	17	6	6	NUM
admet-470	44	18	cm	cm	NOUN
admet-470	44	19	/	/	SYM
admet-470	44	20	s	s	PROPN
admet-470	44	21	,	,	PUNCT
admet-470	44	22	otherwise	otherwise	ADV
admet-470	44	23	fabs	fab	VERB
admet-470	44	24	=	=	SYM
admet-470	44	25	papp	papp	NOUN
admet-470	44	26	,	,	PUNCT
admet-470	44	27	(	(	PUNCT
admet-470	44	28	7	7	X
admet-470	44	29	)	)	PUNCT
admet-470	44	30	where	where	SCONJ
admet-470	44	31	papp	papp	NOUN
admet-470	44	32	is	be	AUX
admet-470	44	33	apparent	apparent	ADJ
admet-470	44	34	permeability	permeability	NOUN
admet-470	44	35	measured	measure	VERB
admet-470	44	36	in	in	ADP
admet-470	44	37	caco2	caco2	NOUN
admet-470	44	38	cells	cell	NOUN
admet-470	44	39	,	,	PUNCT
admet-470	44	40	utilising	utilise	VERB
admet-470	44	41	the	the	DET
admet-470	44	42	intrinsic	intrinsic	ADJ
admet-470	44	43	caco2	caco2	NOUN
admet-470	44	44	permeability	permeability	NOUN
admet-470	44	45	assay	assay	VERB
admet-470	44	46	[	[	X
admet-470	44	47	14	14	NUM
admet-470	44	48	]	]	PUNCT
admet-470	44	49	(	(	PUNCT
admet-470	44	50	predicted	predict	VERB
admet-470	44	51	)	)	PUNCT
admet-470	44	52	.	.	PUNCT
admet-470	45	1	𝐹ℎ	𝐹ℎ	PROPN
admet-470	45	2	=	=	NOUN
admet-470	45	3	1	1	NUM
admet-470	45	4	−	−	NOUN
admet-470	45	5	𝐶𝑙𝑏/𝑄ℎ	𝐶𝑙𝑏/𝑄ℎ	PUNCT
admet-470	45	6	(	(	PUNCT
admet-470	45	7	8)	8)	NUM
admet-470	45	8	𝐶𝐿𝑖𝑛𝑡𝑖𝑛	𝐶𝐿𝑖𝑛𝑡𝑖𝑛	PROPN
admet-470	45	9	𝑣𝑖𝑣𝑜	𝑣𝑖𝑣𝑜	NOUN
admet-470	45	10	=	=	PUNCT
admet-470	45	11	𝐶𝐹	𝐶𝐹	PROPN
admet-470	45	12	∙	∙	PROPN
admet-470	45	13	𝐶𝐿𝑖𝑛𝑡𝑠𝑐	𝐶𝐿𝑖𝑛𝑡𝑠𝑐	PROPN
admet-470	45	14	,	,	PUNCT
admet-470	45	15	(	(	PUNCT
admet-470	45	16	9	9	NUM
admet-470	45	17	)	)	PUNCT
admet-470	45	18	where	where	SCONJ
admet-470	45	19	cf	cf	NOUN
admet-470	45	20	is	be	AUX
admet-470	45	21	an	an	DET
admet-470	45	22	empirical	empirical	ADJ
admet-470	45	23	correction	correction	NOUN
admet-470	45	24	factor	factor	NOUN
admet-470	45	25	adopted	adopt	VERB
admet-470	45	26	for	for	ADP
admet-470	45	27	the	the	DET
admet-470	45	28	simplified	simplified	ADJ
admet-470	45	29	regression	regression	NOUN
admet-470	45	30	offset	offset	NOUN
admet-470	45	31	approach	approach	NOUN
admet-470	45	32	(	(	PUNCT
admet-470	45	33	cf=3	cf=3	NOUN
admet-470	45	34	,	,	PUNCT
admet-470	45	35	see	see	VERB
admet-470	45	36	below	below	ADV
admet-470	45	37	)	)	PUNCT
admet-470	45	38	,	,	PUNCT
admet-470	45	39	and	and	CCONJ
admet-470	45	40	clintsc	clintsc	NOUN
admet-470	45	41	is	be	AUX
admet-470	45	42	the	the	DET
admet-470	45	43	scaled	scale	VERB
admet-470	45	44	intrinsic	intrinsic	ADJ
admet-470	45	45	clearance	clearance	NOUN
admet-470	45	46	from	from	ADP
admet-470	45	47	the	the	DET
admet-470	45	48	human	human	ADJ
admet-470	45	49	hepatocyte	hepatocyte	NOUN
admet-470	45	50	incubation	incubation	NOUN
admet-470	45	51	(	(	PUNCT
admet-470	45	52	eq	eq	NOUN
admet-470	45	53	.	.	PROPN
admet-470	45	54	9a	9a	NOUN
admet-470	45	55	)	)	PUNCT
admet-470	45	56	.	.	PUNCT
admet-470	46	1	𝐶𝐿𝑖𝑛𝑡𝑠𝑐	𝐶𝐿𝑖𝑛𝑡𝑠𝑐	PROPN
admet-470	46	2	=	=	PUNCT
admet-470	46	3	𝐶𝐿𝑖𝑛𝑡𝐻𝐻	𝐶𝐿𝑖𝑛𝑡𝐻𝐻	PROPN
admet-470	46	4	∙	∙	PROPN
admet-470	46	5	𝑆𝐹𝐻𝐻/𝑓𝑢𝑖𝑛𝑐	𝑆𝐹𝐻𝐻/𝑓𝑢𝑖𝑛𝑐	PROPN
admet-470	46	6	,	,	PUNCT
admet-470	46	7	(	(	PUNCT
admet-470	46	8	9a	9a	NOUN
admet-470	46	9	)	)	PUNCT
admet-470	46	10	where	where	SCONJ
admet-470	46	11	clinthh	clinthh	ADJ
admet-470	46	12	is	be	AUX
admet-470	46	13	the	the	DET
admet-470	46	14	intrinsic	intrinsic	ADJ
admet-470	46	15	clearance	clearance	NOUN
admet-470	46	16	in	in	ADP
admet-470	46	17	human	human	ADJ
admet-470	46	18	hepatocytes	hepatocyte	NOUN
admet-470	46	19	(	(	PUNCT
admet-470	46	20	predicted	predict	VERB
admet-470	46	21	)	)	PUNCT
admet-470	46	22	,	,	PUNCT
admet-470	46	23	sfhh	sfhh	PROPN
admet-470	46	24	are	be	AUX
admet-470	46	25	the	the	DET
admet-470	46	26	scaling	scale	VERB
admet-470	46	27	factors	factor	NOUN
admet-470	46	28	(	(	PUNCT
admet-470	46	29	120	120	NUM
admet-470	46	30	million	million	NUM
admet-470	46	31	cells	cell	NOUN
admet-470	46	32	per	per	ADP
admet-470	46	33	g	g	NOUN
admet-470	46	34	liver	liver	NOUN
admet-470	46	35	x	x	NOUN
admet-470	46	36	1680	1680	NUM
admet-470	46	37	g	g	NOUN
admet-470	46	38	liver	liver	NOUN
admet-470	46	39	weight	weight	NOUN
admet-470	46	40	/	/	SYM
admet-470	46	41	70	70	NUM
admet-470	46	42	kg	kg	NOUN
admet-470	46	43	body	body	NOUN
admet-470	46	44	weight	weight	NOUN
admet-470	46	45	=	=	NOUN
admet-470	46	46	2.88	2.88	NUM
admet-470	46	47	)	)	PUNCT
admet-470	46	48	and	and	CCONJ
admet-470	46	49	fuinc	fuinc	PROPN
admet-470	46	50	is	be	AUX
admet-470	46	51	the	the	DET
admet-470	46	52	fraction	fraction	NOUN
admet-470	46	53	unbound	unbound	NOUN
admet-470	46	54	in	in	ADP
admet-470	46	55	the	the	DET
admet-470	46	56	hepatocyte	hepatocyte	NOUN
admet-470	46	57	incubation	incubation	NOUN
admet-470	46	58	(	(	PUNCT
admet-470	46	59	predicted	predict	VERB
admet-470	46	60	)	)	PUNCT
admet-470	46	61	.	.	PUNCT
admet-470	47	1	the	the	DET
admet-470	47	2	minimum	minimum	ADJ
admet-470	47	3	potency	potency	NOUN
admet-470	47	4	value	value	NOUN
admet-470	47	5	,	,	PUNCT
admet-470	47	6	e.g.	e.g.	ADV
admet-470	47	7	,	,	PUNCT
admet-470	47	8	“	"	PUNCT
admet-470	47	9	threshold	threshold	NOUN
admet-470	47	10	pic50	pic50	NOUN
admet-470	47	11	”	"	PUNCT
admet-470	47	12	based	base	VERB
admet-470	47	13	on	on	ADP
admet-470	47	14	cmin	cmin	NOUN
admet-470	47	15	,	,	PUNCT
admet-470	47	16	is	be	AUX
admet-470	47	17	then	then	ADV
admet-470	47	18	calculated	calculate	VERB
admet-470	47	19	as	as	ADP
admet-470	47	20	the	the	DET
admet-470	47	21	negative	negative	ADJ
admet-470	47	22	logarithm	logarithm	NOUN
admet-470	47	23	of	of	ADP
admet-470	47	24	the	the	DET
admet-470	47	25	predicted	predict	VERB
admet-470	47	26	concentration	concentration	NOUN
admet-470	47	27	considering	consider	VERB
admet-470	47	28	the	the	DET
admet-470	47	29	specific	specific	ADJ
admet-470	47	30	fold	fold	ADJ
admet-470	47	31	coverage	coverage	NOUN
admet-470	47	32	,	,	PUNCT
admet-470	47	33	typically	typically	ADV
admet-470	47	34	set	set	VERB
admet-470	47	35	to	to	ADP
admet-470	47	36	1	1	NUM
admet-470	47	37	or	or	CCONJ
admet-470	47	38	3	3	NUM
admet-470	47	39	(	(	PUNCT
admet-470	47	40	eq	eq	NOUN
admet-470	47	41	.	.	PROPN
admet-470	47	42	10	10	NUM
admet-470	47	43	)	)	PUNCT
admet-470	47	44	.	.	PUNCT
admet-470	48	1	threshold	threshold	NOUN
admet-470	48	2	pic50	pic50	NOUN
admet-470	48	3	=	=	PUNCT
admet-470	48	4	−log(𝐶min	−log(𝐶min	NOUN
admet-470	48	5	fold	fold	NOUN
admet-470	48	6	coverage⁄	coverage⁄	PROPN
admet-470	48	7	)	)	PUNCT
admet-470	48	8	(	(	PUNCT
admet-470	48	9	10	10	NUM
admet-470	48	10	)	)	PUNCT
admet-470	48	11	simplified	simplified	ADJ
admet-470	48	12	regression	regression	NOUN
admet-470	48	13	offset	offset	NOUN
admet-470	48	14	approach	approach	NOUN
admet-470	48	15	–	–	PUNCT
admet-470	48	16	correction	correction	NOUN
admet-470	48	17	factor	factor	NOUN
admet-470	48	18	(	(	PUNCT
admet-470	48	19	cf	cf	NOUN
admet-470	48	20	)	)	PUNCT
admet-470	48	21	the	the	DET
admet-470	48	22	regression	regression	NOUN
admet-470	48	23	offset	offset	VERB
admet-470	48	24	approach	approach	NOUN
admet-470	49	1	[	[	X
admet-470	49	2	15	15	NUM
admet-470	49	3	]	]	PUNCT
admet-470	49	4	was	be	AUX
admet-470	49	5	shown	show	VERB
admet-470	49	6	to	to	PART
admet-470	49	7	improve	improve	VERB
admet-470	49	8	in	in	ADP
admet-470	49	9	vitro	vitro	X
admet-470	49	10	to	to	ADP
admet-470	49	11	in	in	ADP
admet-470	49	12	vivo	vivo	ADJ
admet-470	49	13	scaling	scaling	NOUN
admet-470	49	14	of	of	ADP
admet-470	49	15	clearance	clearance	NOUN
admet-470	49	16	,	,	PUNCT
admet-470	49	17	especially	especially	ADV
admet-470	49	18	when	when	SCONJ
admet-470	49	19	experiments	experiment	NOUN
admet-470	49	20	where	where	SCONJ
admet-470	49	21	compared	compare	VERB
admet-470	49	22	from	from	ADP
admet-470	49	23	different	different	ADJ
admet-470	49	24	laboratories	laboratory	NOUN
admet-470	49	25	(	(	PUNCT
admet-470	49	26	sites	site	NOUN
admet-470	49	27	)	)	PUNCT
admet-470	49	28	and	and	CCONJ
admet-470	49	29	using	use	VERB
admet-470	49	30	different	different	ADJ
admet-470	49	31	batches	batch	NOUN
admet-470	49	32	of	of	ADP
admet-470	49	33	hepatocytes	hepatocyte	NOUN
admet-470	49	34	or	or	CCONJ
admet-470	49	35	microsomes	microsome	NOUN
admet-470	49	36	.	.	PUNCT
admet-470	50	1	extensive	extensive	ADJ
admet-470	50	2	in	in	ADP
admet-470	50	3	-	-	PUNCT
admet-470	50	4	house	house	NOUN
admet-470	50	5	data	datum	NOUN
admet-470	50	6	analysis	analysis	NOUN
admet-470	50	7	(	(	PUNCT
admet-470	50	8	data	datum	NOUN
admet-470	50	9	not	not	PART
admet-470	50	10	shown	show	VERB
admet-470	50	11	)	)	PUNCT
admet-470	50	12	indicated	indicate	VERB
admet-470	50	13	that	that	SCONJ
admet-470	50	14	overall	overall	ADJ
admet-470	50	15	the	the	DET
admet-470	50	16	regression	regression	NOUN
admet-470	50	17	slope	slope	NOUN
admet-470	50	18	can	can	AUX
admet-470	50	19	be	be	AUX
admet-470	50	20	set	set	VERB
admet-470	50	21	to	to	ADP
admet-470	50	22	1	1	NUM
admet-470	50	23	and	and	CCONJ
admet-470	50	24	the	the	DET
admet-470	50	25	offset	offset	NOUN
admet-470	50	26	to	to	ADP
admet-470	50	27	about	about	ADV
admet-470	50	28	0.5	0.5	NUM
admet-470	50	29	,	,	PUNCT
admet-470	50	30	giving	give	VERB
admet-470	50	31	an	an	DET
admet-470	50	32	equivalent	equivalent	ADJ
admet-470	50	33	level	level	NOUN
admet-470	50	34	of	of	ADP
admet-470	50	35	correct	correct	ADJ
admet-470	50	36	predictions	prediction	NOUN
admet-470	50	37	in	in	ADP
admet-470	50	38	three	three	NUM
admet-470	50	39	species	specie	NOUN
admet-470	50	40	,	,	PUNCT
admet-470	50	41	human	human	NOUN
admet-470	50	42	,	,	PUNCT
admet-470	50	43	rat	rat	NOUN
admet-470	50	44	and	and	CCONJ
admet-470	50	45	dog	dog	NOUN
admet-470	50	46	.	.	PUNCT
admet-470	51	1	thus	thus	ADV
admet-470	51	2	,	,	PUNCT
admet-470	51	3	in	in	ADP
admet-470	51	4	vivo	vivo	NOUN
admet-470	51	5	clint	clint	NOUN
admet-470	51	6	can	can	AUX
admet-470	51	7	be	be	AUX
admet-470	51	8	estimated	estimate	VERB
admet-470	51	9	by	by	ADP
admet-470	51	10	multiplying	multiply	VERB
admet-470	51	11	the	the	DET
admet-470	51	12	scaled	scale	VERB
admet-470	51	13	clint	clint	NOUN
admet-470	51	14	with	with	ADP
admet-470	51	15	a	a	DET
admet-470	51	16	correction	correction	NOUN
admet-470	51	17	factor	factor	NOUN
admet-470	51	18	of	of	ADP
admet-470	51	19	3	3	NUM
admet-470	51	20	.	.	PUNCT
admet-470	52	1	here	here	ADV
admet-470	52	2	we	we	PRON
admet-470	52	3	adopt	adopt	VERB
admet-470	52	4	this	this	DET
admet-470	52	5	procedure	procedure	NOUN
admet-470	52	6	to	to	PART
admet-470	52	7	estimate	estimate	VERB
admet-470	52	8	in	in	ADP
admet-470	52	9	vivo	vivo	ADJ
admet-470	52	10	clint	clint	NOUN
admet-470	52	11	directly	directly	ADV
admet-470	52	12	from	from	ADP
admet-470	52	13	in	in	ADP
admet-470	52	14	silico	silico	NOUN
admet-470	52	15	predictions	prediction	NOUN
admet-470	52	16	.	.	PUNCT
admet-470	53	1	in	in	ADP
admet-470	53	2	silico	silico	NOUN
admet-470	53	3	models	model	NOUN
admet-470	53	4	five	five	NUM
admet-470	53	5	in	in	ADP
admet-470	53	6	silico	silico	NOUN
admet-470	53	7	models	model	NOUN
admet-470	53	8	were	be	AUX
admet-470	53	9	used	use	VERB
admet-470	53	10	as	as	ADP
admet-470	53	11	input	input	NOUN
admet-470	53	12	for	for	ADP
admet-470	53	13	the	the	DET
admet-470	53	14	above	above	ADJ
admet-470	53	15	calculations	calculation	NOUN
admet-470	53	16	.	.	PUNCT
admet-470	54	1	human	human	ADJ
admet-470	54	2	volume	volume	NOUN
admet-470	54	3	of	of	ADP
admet-470	54	4	distribution	distribution	NOUN
admet-470	54	5	at	at	ADP
admet-470	54	6	𝐶𝑙𝑏	𝐶𝑙𝑏	PROPN
admet-470	54	7	=	=	SYM
admet-470	54	8	𝑄ℎ∙𝐶𝐿𝑖𝑛𝑡𝑖𝑛	𝑄ℎ∙𝐶𝐿𝑖𝑛𝑡𝑖𝑛	ADJ
admet-470	54	9	𝑣𝑖𝑣𝑜	𝑣𝑖𝑣𝑜	NOUN
admet-470	54	10	∙𝑓𝑢𝑏	∙𝑓𝑢𝑏	PROPN
admet-470	54	11	𝑄ℎ+𝐶𝐿𝑖𝑛𝑡𝑖𝑛	𝑄ℎ+𝐶𝐿𝑖𝑛𝑡𝑖𝑛	PROPN
admet-470	54	12	𝑣𝑖𝑣𝑜	𝑣𝑖𝑣𝑜	NOUN
admet-470	54	13	∙𝑓𝑢𝑏	∙𝑓𝑢𝑏	PROPN
admet-470	54	14	susanne	susanne	PROPN
admet-470	54	15	winiwarter	winiwarter	PROPN
admet-470	54	16	et	et	PROPN
admet-470	54	17	al	al	PROPN
admet-470	54	18	.	.	PROPN
admet-470	54	19	admet	admet	PROPN
admet-470	54	20	&	&	CCONJ
admet-470	54	21	dmpk	dmpk	PROPN
admet-470	54	22	6(1	6(1	NUM
admet-470	54	23	)	)	PUNCT
admet-470	54	24	(	(	PUNCT
admet-470	54	25	2018	2018	NUM
admet-470	54	26	)	)	PUNCT
admet-470	54	27	15	15	NUM
admet-470	54	28	-	-	SYM
admet-470	54	29	33	33	NUM
admet-470	54	30	18	18	NUM
admet-470	54	31	steady	steady	ADJ
admet-470	54	32	state	state	NOUN
admet-470	54	33	,	,	PUNCT
admet-470	54	34	intrinsic	intrinsic	ADJ
admet-470	54	35	caco2	caco2	NOUN
admet-470	54	36	permeability	permeability	NOUN
admet-470	54	37	,	,	PUNCT
admet-470	54	38	human	human	ADJ
admet-470	54	39	plasma	plasma	NOUN
admet-470	54	40	protein	protein	NOUN
admet-470	54	41	binding	bind	VERB
admet-470	54	42	,	,	PUNCT
admet-470	54	43	human	human	ADJ
admet-470	54	44	hepatocyte	hepatocyte	NOUN
admet-470	54	45	intrinsic	intrinsic	ADJ
admet-470	54	46	clearance	clearance	NOUN
admet-470	54	47	,	,	PUNCT
admet-470	54	48	and	and	CCONJ
admet-470	54	49	fraction	fraction	NOUN
admet-470	54	50	unbound	unbound	NOUN
admet-470	54	51	in	in	ADP
admet-470	54	52	the	the	DET
admet-470	54	53	hepatocyte	hepatocyte	NOUN
admet-470	54	54	incubation	incubation	NOUN
admet-470	54	55	.	.	PUNCT
admet-470	55	1	all	all	PRON
admet-470	55	2	but	but	SCONJ
admet-470	55	3	the	the	DET
admet-470	55	4	volume	volume	NOUN
admet-470	55	5	of	of	ADP
admet-470	55	6	distribution	distribution	NOUN
admet-470	55	7	model	model	NOUN
admet-470	55	8	used	use	VERB
admet-470	55	9	astrazeneca	astrazeneca	PROPN
admet-470	55	10	in	in	ADP
admet-470	55	11	-	-	PUNCT
admet-470	55	12	house	house	NOUN
admet-470	55	13	experimental	experimental	ADJ
admet-470	55	14	data	datum	NOUN
admet-470	55	15	.	.	PUNCT
admet-470	56	1	all	all	DET
admet-470	56	2	models	model	NOUN
admet-470	56	3	are	be	AUX
admet-470	56	4	available	available	ADJ
admet-470	56	5	within	within	ADP
admet-470	56	6	astrazeneca	astrazeneca	PROPN
admet-470	56	7	.	.	PUNCT
admet-470	57	1	1	1	X
admet-470	57	2	.	.	PUNCT
admet-470	57	3	human	human	ADJ
admet-470	57	4	volume	volume	NOUN
admet-470	57	5	of	of	ADP
admet-470	57	6	distribution	distribution	NOUN
admet-470	57	7	(	(	PUNCT
admet-470	57	8	v	v	NOUN
admet-470	57	9	)	)	PUNCT
admet-470	57	10	human	human	ADJ
admet-470	57	11	volume	volume	NOUN
admet-470	57	12	of	of	ADP
admet-470	57	13	distribution	distribution	NOUN
admet-470	57	14	data	datum	NOUN
admet-470	57	15	for	for	ADP
admet-470	57	16	about	about	ADV
admet-470	57	17	700	700	NUM
admet-470	57	18	compounds	compound	NOUN
admet-470	57	19	were	be	AUX
admet-470	57	20	collated	collate	VERB
admet-470	57	21	from	from	ADP
admet-470	57	22	literature	literature	NOUN
admet-470	57	23	[	[	X
admet-470	57	24	16	16	NUM
admet-470	57	25	-	-	SYM
admet-470	57	26	18	18	NUM
admet-470	57	27	]	]	PUNCT
admet-470	57	28	and	and	CCONJ
admet-470	57	29	randomly	randomly	ADV
admet-470	57	30	split	split	VERB
admet-470	57	31	into	into	ADP
admet-470	57	32	a	a	DET
admet-470	57	33	training	training	NOUN
admet-470	57	34	and	and	CCONJ
admet-470	57	35	test	test	NOUN
admet-470	57	36	set	set	VERB
admet-470	57	37	(	(	PUNCT
admet-470	57	38	n	n	NOUN
admet-470	57	39	=	=	SYM
admet-470	57	40	544	544	NUM
admet-470	57	41	and	and	CCONJ
admet-470	57	42	144	144	NUM
admet-470	57	43	,	,	PUNCT
admet-470	57	44	respectively	respectively	ADV
admet-470	57	45	)	)	PUNCT
admet-470	57	46	.	.	PUNCT
admet-470	58	1	both	both	DET
admet-470	58	2	acids	acid	NOUN
admet-470	58	3	,	,	PUNCT
admet-470	58	4	bases	basis	NOUN
admet-470	58	5	,	,	PUNCT
admet-470	58	6	neutral	neutral	ADJ
admet-470	58	7	and	and	CCONJ
admet-470	58	8	zwitterionic	zwitterionic	ADJ
admet-470	58	9	compounds	compound	NOUN
admet-470	58	10	are	be	AUX
admet-470	58	11	included	include	VERB
admet-470	58	12	in	in	ADP
admet-470	58	13	both	both	DET
admet-470	58	14	datasets	dataset	NOUN
admet-470	58	15	.	.	PUNCT
admet-470	59	1	it	it	PRON
admet-470	59	2	is	be	AUX
admet-470	59	3	a	a	DET
admet-470	59	4	random	random	ADJ
admet-470	59	5	forest	forest	NOUN
admet-470	59	6	model	model	NOUN
admet-470	59	7	[	[	X
admet-470	59	8	19	19	NUM
admet-470	59	9	]	]	PUNCT
admet-470	59	10	using	use	VERB
admet-470	59	11	physicochemical	physicochemical	ADJ
admet-470	59	12	descriptors	descriptor	NOUN
admet-470	59	13	[	[	X
admet-470	59	14	20	20	NUM
admet-470	59	15	]	]	PUNCT
admet-470	59	16	including	include	VERB
admet-470	59	17	acd	acd	NOUN
admet-470	59	18	log	log	NOUN
admet-470	59	19	p	p	NOUN
admet-470	59	20	and	and	CCONJ
admet-470	59	21	log	log	VERB
admet-470	59	22	d	d	PROPN
admet-470	60	1	[	[	X
admet-470	60	2	21	21	NUM
admet-470	60	3	]	]	PUNCT
admet-470	61	1	and	and	CCONJ
admet-470	61	2	clog	clog	VERB
admet-470	61	3	p	p	PROPN
admet-470	61	4	[	[	X
admet-470	61	5	22	22	NUM
admet-470	61	6	]	]	PUNCT
admet-470	61	7	.	.	PUNCT
admet-470	62	1	the	the	DET
admet-470	62	2	experimental	experimental	ADJ
admet-470	62	3	data	datum	NOUN
admet-470	62	4	is	be	AUX
admet-470	62	5	modelled	model	VERB
admet-470	62	6	in	in	ADP
admet-470	62	7	its	its	PRON
admet-470	62	8	logarithmic	logarithmic	ADJ
admet-470	62	9	form	form	NOUN
admet-470	62	10	.	.	PUNCT
admet-470	63	1	the	the	DET
admet-470	63	2	prediction	prediction	NOUN
admet-470	63	3	explains	explain	VERB
admet-470	63	4	~70	~70	NUM
admet-470	63	5	%	%	NOUN
admet-470	63	6	of	of	ADP
admet-470	63	7	the	the	DET
admet-470	63	8	variance	variance	NOUN
admet-470	63	9	of	of	ADP
admet-470	63	10	the	the	DET
admet-470	63	11	test	test	NOUN
admet-470	63	12	set	set	NOUN
admet-470	63	13	,	,	PUNCT
admet-470	63	14	and	and	CCONJ
admet-470	63	15	has	have	VERB
admet-470	63	16	an	an	DET
admet-470	63	17	error	error	NOUN
admet-470	63	18	in	in	ADP
admet-470	63	19	prediction	prediction	NOUN
admet-470	63	20	of	of	ADP
admet-470	63	21	0.4	0.4	NUM
admet-470	63	22	log	log	NOUN
admet-470	63	23	units	unit	NOUN
admet-470	63	24	.	.	PUNCT
admet-470	64	1	2	2	X
admet-470	64	2	.	.	X
admet-470	64	3	intrinsic	intrinsic	ADJ
admet-470	64	4	caco2	caco2	NOUN
admet-470	64	5	permeability	permeability	NOUN
admet-470	64	6	(	(	PUNCT
admet-470	64	7	papp	papp	PROPN
admet-470	64	8	)	)	PUNCT
admet-470	64	9	the	the	DET
admet-470	64	10	model	model	NOUN
admet-470	64	11	is	be	AUX
admet-470	64	12	built	build	VERB
admet-470	64	13	on	on	ADP
admet-470	64	14	in	in	ADP
admet-470	64	15	-	-	PUNCT
admet-470	64	16	house	house	NOUN
admet-470	64	17	data	datum	NOUN
admet-470	64	18	of	of	ADP
admet-470	64	19	intrinsic	intrinsic	ADJ
admet-470	64	20	caco2	caco2	NOUN
admet-470	64	21	permeability	permeability	NOUN
admet-470	64	22	,	,	PUNCT
admet-470	64	23	apparent	apparent	ADJ
admet-470	64	24	permeability	permeability	NOUN
admet-470	64	25	measured	measure	VERB
admet-470	64	26	in	in	ADP
admet-470	64	27	caco2	caco2	NOUN
admet-470	64	28	cells	cell	NOUN
admet-470	64	29	in	in	ADP
admet-470	64	30	presence	presence	NOUN
admet-470	64	31	of	of	ADP
admet-470	64	32	a	a	DET
admet-470	64	33	defined	define	VERB
admet-470	64	34	transport	transport	NOUN
admet-470	64	35	inhibitor	inhibitor	NOUN
admet-470	64	36	cocktail	cocktail	NOUN
admet-470	64	37	as	as	SCONJ
admet-470	64	38	described	describe	VERB
admet-470	64	39	earlier	early	ADV
admet-470	64	40	[	[	X
admet-470	64	41	14	14	NUM
admet-470	64	42	]	]	PUNCT
admet-470	64	43	,	,	PUNCT
admet-470	64	44	and	and	CCONJ
admet-470	64	45	updated	update	VERB
admet-470	64	46	about	about	ADP
admet-470	64	47	every	every	DET
admet-470	64	48	sixth	sixth	ADJ
admet-470	64	49	month	month	NOUN
admet-470	64	50	.	.	PUNCT
admet-470	65	1	the	the	DET
admet-470	65	2	present	present	ADJ
admet-470	65	3	training	training	NOUN
admet-470	65	4	set	set	NOUN
admet-470	65	5	consists	consist	VERB
admet-470	65	6	of	of	ADP
admet-470	65	7	>	>	SYM
admet-470	65	8	4,000	4,000	NUM
admet-470	65	9	data	datum	NOUN
admet-470	65	10	points	point	NOUN
admet-470	65	11	.	.	PUNCT
admet-470	66	1	about	about	ADV
admet-470	66	2	100	100	NUM
admet-470	66	3	simple	simple	ADJ
admet-470	66	4	physicochemical	physicochemical	ADJ
admet-470	66	5	descriptors	descriptor	NOUN
admet-470	66	6	[	[	X
admet-470	66	7	20	20	NUM
admet-470	66	8	]	]	PUNCT
admet-470	66	9	including	include	VERB
admet-470	66	10	acd	acd	NOUN
admet-470	66	11	log	log	NOUN
admet-470	66	12	p	p	NOUN
admet-470	66	13	and	and	CCONJ
admet-470	66	14	log	log	VERB
admet-470	66	15	d	d	PROPN
admet-470	67	1	[	[	X
admet-470	67	2	21	21	NUM
admet-470	67	3	]	]	PUNCT
admet-470	68	1	and	and	CCONJ
admet-470	68	2	clog	clog	VERB
admet-470	68	3	p	p	PROPN
admet-470	68	4	[	[	X
admet-470	68	5	22	22	NUM
admet-470	68	6	]	]	PUNCT
admet-470	68	7	are	be	AUX
admet-470	68	8	calculated	calculate	VERB
admet-470	68	9	from	from	ADP
admet-470	68	10	the	the	DET
admet-470	68	11	compound	compound	NOUN
admet-470	68	12	structures	structure	NOUN
admet-470	68	13	.	.	PUNCT
admet-470	69	1	the	the	DET
admet-470	69	2	data	data	NOUN
admet-470	69	3	is	be	AUX
admet-470	69	4	modelled	model	VERB
admet-470	69	5	as	as	ADP
admet-470	69	6	log	log	NOUN
admet-470	69	7	papp	papp	NOUN
admet-470	69	8	using	use	VERB
admet-470	69	9	random	random	ADJ
admet-470	69	10	forest	forest	NOUN
admet-470	69	11	regression	regression	NOUN
admet-470	69	12	[	[	X
admet-470	69	13	19	19	NUM
admet-470	69	14	]	]	PUNCT
admet-470	69	15	as	as	SCONJ
admet-470	69	16	implemented	implement	VERB
admet-470	69	17	in	in	ADP
admet-470	69	18	scikit	scikit	NOUN
admet-470	69	19	-	-	PUNCT
admet-470	69	20	learn	learn	VERB
admet-470	69	21	[	[	X
admet-470	69	22	23	23	NUM
admet-470	69	23	]	]	PUNCT
admet-470	69	24	.	.	PUNCT
admet-470	70	1	the	the	DET
admet-470	70	2	latest	late	ADJ
admet-470	70	3	temporal	temporal	ADJ
admet-470	70	4	test	test	NOUN
admet-470	70	5	set	set	NOUN
admet-470	70	6	comprises	comprise	VERB
admet-470	70	7	about	about	ADP
admet-470	70	8	300	300	NUM
admet-470	70	9	compounds	compound	NOUN
admet-470	70	10	and	and	CCONJ
admet-470	70	11	shows	show	VERB
admet-470	70	12	an	an	DET
admet-470	70	13	r2	r2	NOUN
admet-470	70	14	of	of	ADP
admet-470	70	15	0.4	0.4	NUM
admet-470	70	16	and	and	CCONJ
admet-470	70	17	a	a	DET
admet-470	70	18	root	root	NOUN
admet-470	70	19	mean	mean	VERB
admet-470	70	20	squared	square	VERB
admet-470	70	21	error	error	NOUN
admet-470	70	22	of	of	ADP
admet-470	70	23	predictions	prediction	NOUN
admet-470	70	24	(	(	PUNCT
admet-470	70	25	rmsep	rmsep	NOUN
admet-470	70	26	)	)	PUNCT
admet-470	70	27	of	of	ADP
admet-470	70	28	0.6	0.6	NUM
admet-470	70	29	(	(	PUNCT
admet-470	70	30	log	log	NOUN
admet-470	70	31	scale	scale	NOUN
admet-470	70	32	)	)	PUNCT
admet-470	70	33	,	,	PUNCT
admet-470	70	34	with	with	ADP
admet-470	70	35	about	about	ADV
admet-470	70	36	60	60	NUM
admet-470	70	37	%	%	NOUN
admet-470	70	38	of	of	ADP
admet-470	70	39	the	the	DET
admet-470	70	40	compounds	compound	NOUN
admet-470	70	41	being	be	AUX
admet-470	70	42	within	within	ADP
admet-470	70	43	3	3	NOUN
admet-470	70	44	-	-	ADJ
admet-470	70	45	fold	fold	NOUN
admet-470	70	46	of	of	ADP
admet-470	70	47	the	the	DET
admet-470	70	48	experimental	experimental	ADJ
admet-470	70	49	value	value	NOUN
admet-470	70	50	.	.	PUNCT
admet-470	71	1	the	the	DET
admet-470	71	2	model	model	NOUN
admet-470	71	3	can	can	AUX
admet-470	71	4	be	be	AUX
admet-470	71	5	used	use	VERB
admet-470	71	6	to	to	PART
admet-470	71	7	distinguish	distinguish	VERB
admet-470	71	8	between	between	ADP
admet-470	71	9	high	high	ADJ
admet-470	71	10	and	and	CCONJ
admet-470	71	11	low	low	ADJ
admet-470	71	12	permeability	permeability	NOUN
admet-470	71	13	compounds	compound	NOUN
admet-470	71	14	with	with	ADP
admet-470	71	15	classification	classification	NOUN
admet-470	71	16	accuracy	accuracy	NOUN
admet-470	71	17	above	above	ADP
admet-470	71	18	0.8	0.8	NUM
admet-470	71	19	.	.	PUNCT
admet-470	72	1	3	3	X
admet-470	72	2	.	.	X
admet-470	72	3	human	human	ADJ
admet-470	72	4	plasma	plasma	NOUN
admet-470	72	5	protein	protein	NOUN
admet-470	72	6	binding	bind	VERB
admet-470	72	7	as	as	ADP
admet-470	72	8	fraction	fraction	NOUN
admet-470	72	9	unbound	unbound	NOUN
admet-470	72	10	(	(	PUNCT
admet-470	72	11	fu	fu	PROPN
admet-470	72	12	)	)	PUNCT
admet-470	72	13	the	the	DET
admet-470	72	14	model	model	NOUN
admet-470	72	15	is	be	AUX
admet-470	72	16	built	build	VERB
admet-470	72	17	on	on	ADP
admet-470	72	18	in	in	ADP
admet-470	72	19	-	-	PUNCT
admet-470	72	20	house	house	NOUN
admet-470	72	21	data	datum	NOUN
admet-470	72	22	of	of	ADP
admet-470	72	23	human	human	ADJ
admet-470	72	24	plasma	plasma	NOUN
admet-470	72	25	protein	protein	NOUN
admet-470	72	26	binding	bind	VERB
admet-470	72	27	generated	generate	VERB
admet-470	72	28	using	use	VERB
admet-470	72	29	equilibrium	equilibrium	NOUN
admet-470	72	30	dialysis	dialysis	NOUN
admet-470	72	31	in	in	ADP
admet-470	72	32	high	high	ADJ
admet-470	72	33	throughput	throughput	NOUN
admet-470	72	34	assays	assay	NOUN
admet-470	72	35	as	as	SCONJ
admet-470	72	36	described	describe	VERB
admet-470	72	37	earlier	early	ADV
admet-470	72	38	[	[	X
admet-470	72	39	24	24	NUM
admet-470	72	40	-	-	SYM
admet-470	72	41	26	26	NUM
admet-470	72	42	]	]	PUNCT
admet-470	72	43	.	.	PUNCT
admet-470	73	1	it	it	PRON
admet-470	73	2	is	be	AUX
admet-470	73	3	updated	update	VERB
admet-470	73	4	monthly	monthly	ADV
admet-470	73	5	.	.	PUNCT
admet-470	74	1	the	the	DET
admet-470	74	2	present	present	ADJ
admet-470	74	3	training	training	NOUN
admet-470	74	4	set	set	NOUN
admet-470	74	5	consists	consist	VERB
admet-470	74	6	of	of	ADP
admet-470	74	7	almost	almost	ADV
admet-470	74	8	90,000	90,000	NUM
admet-470	74	9	compounds	compound	NOUN
admet-470	74	10	.	.	PUNCT
admet-470	75	1	the	the	DET
admet-470	75	2	data	data	NOUN
admet-470	75	3	is	be	AUX
admet-470	75	4	modelled	model	VERB
admet-470	75	5	as	as	ADP
admet-470	75	6	log	log	PROPN
admet-470	75	7	k	k	PROPN
admet-470	75	8	(=	(=	X
admet-470	75	9	log[(fraction	log[(fraction	PROPN
admet-470	75	10	unbound)/(fraction	unbound)/(fraction	PROPN
admet-470	75	11	bound	bind	VERB
admet-470	75	12	)	)	PUNCT
admet-470	75	13	]	]	PUNCT
admet-470	75	14	)	)	PUNCT
admet-470	75	15	.	.	PUNCT
admet-470	76	1	the	the	DET
admet-470	76	2	modelling	model	VERB
admet-470	76	3	procedure	procedure	NOUN
admet-470	76	4	utilizes	utilize	VERB
admet-470	76	5	support	support	NOUN
admet-470	76	6	vector	vector	NOUN
admet-470	76	7	machines	machine	NOUN
admet-470	76	8	[	[	X
admet-470	76	9	27	27	NUM
admet-470	76	10	]	]	PUNCT
admet-470	76	11	with	with	ADP
admet-470	76	12	a	a	DET
admet-470	76	13	linear	linear	ADJ
admet-470	76	14	kernel	kernel	NOUN
admet-470	76	15	,	,	PUNCT
admet-470	76	16	signature	signature	NOUN
admet-470	76	17	descriptors	descriptor	NOUN
admet-470	76	18	[	[	X
admet-470	76	19	28	28	NUM
admet-470	76	20	]	]	PUNCT
admet-470	76	21	and	and	CCONJ
admet-470	76	22	the	the	DET
admet-470	76	23	conformal	conformal	ADJ
admet-470	76	24	prediction	prediction	NOUN
admet-470	76	25	framework	framework	NOUN
admet-470	76	26	[	[	X
admet-470	76	27	29	29	NUM
admet-470	76	28	]	]	PUNCT
admet-470	76	29	as	as	SCONJ
admet-470	76	30	implemented	implement	VERB
admet-470	76	31	in	in	ADP
admet-470	76	32	cpsign	cpsign	NOUN
admet-470	76	33	from	from	ADP
admet-470	76	34	genettasoft	genettasoft	NOUN
admet-470	76	35	[	[	X
admet-470	76	36	30	30	NUM
admet-470	76	37	]	]	PUNCT
admet-470	76	38	.	.	PUNCT
admet-470	77	1	the	the	DET
admet-470	77	2	latest	late	ADJ
admet-470	77	3	temporal	temporal	ADJ
admet-470	77	4	test	test	NOUN
admet-470	77	5	set	set	NOUN
admet-470	77	6	comprising	comprise	VERB
admet-470	77	7	750	750	NUM
admet-470	77	8	compounds	compound	NOUN
admet-470	77	9	shows	show	VERB
admet-470	77	10	an	an	DET
admet-470	77	11	r2	r2	NOUN
admet-470	77	12	of	of	ADP
admet-470	77	13	0.7	0.7	NUM
admet-470	77	14	and	and	CCONJ
admet-470	77	15	an	an	DET
admet-470	77	16	rmsep	rmsep	NOUN
admet-470	77	17	of	of	ADP
admet-470	77	18	0.4	0.4	NUM
admet-470	77	19	,	,	PUNCT
admet-470	77	20	with	with	ADP
admet-470	77	21	about	about	ADV
admet-470	77	22	80	80	NUM
admet-470	77	23	%	%	NOUN
admet-470	77	24	of	of	ADP
admet-470	77	25	the	the	DET
admet-470	77	26	compounds	compound	NOUN
admet-470	77	27	being	be	AUX
admet-470	77	28	within	within	ADP
admet-470	77	29	3	3	NOUN
admet-470	77	30	-	-	ADJ
admet-470	77	31	fold	fold	NOUN
admet-470	77	32	of	of	ADP
admet-470	77	33	the	the	DET
admet-470	77	34	experimental	experimental	ADJ
admet-470	77	35	value	value	NOUN
admet-470	77	36	of	of	ADP
admet-470	77	37	fu	fu	NOUN
admet-470	77	38	.	.	PUNCT
admet-470	78	1	4	4	X
admet-470	78	2	.	.	X
admet-470	78	3	human	human	ADJ
admet-470	78	4	hepatocyte	hepatocyte	PROPN
admet-470	78	5	intrinsic	intrinsic	ADJ
admet-470	78	6	clearance	clearance	NOUN
admet-470	78	7	(	(	PUNCT
admet-470	78	8	clinthh	clinthh	PROPN
admet-470	78	9	)	)	PUNCT
admet-470	78	10	the	the	DET
admet-470	78	11	model	model	NOUN
admet-470	78	12	is	be	AUX
admet-470	78	13	built	build	VERB
admet-470	78	14	on	on	ADP
admet-470	78	15	in	in	ADP
admet-470	78	16	-	-	PUNCT
admet-470	78	17	house	house	NOUN
admet-470	78	18	data	datum	NOUN
admet-470	78	19	of	of	ADP
admet-470	78	20	human	human	ADJ
admet-470	78	21	hepatocyte	hepatocyte	NOUN
admet-470	78	22	intrinsic	intrinsic	ADJ
admet-470	78	23	clearance	clearance	NOUN
admet-470	78	24	generated	generate	VERB
admet-470	78	25	in	in	ADP
admet-470	78	26	high	high	ADJ
admet-470	78	27	throughput	throughput	NOUN
admet-470	78	28	assays	assay	NOUN
admet-470	78	29	using	use	VERB
admet-470	78	30	incubations	incubation	NOUN
admet-470	78	31	of	of	ADP
admet-470	78	32	either	either	CCONJ
admet-470	78	33	cryopreserved	cryopreserved	ADJ
admet-470	78	34	or	or	CCONJ
admet-470	78	35	fresh	fresh	ADJ
admet-470	78	36	human	human	ADJ
admet-470	78	37	hepatocytes	hepatocyte	NOUN
admet-470	78	38	at	at	ADP
admet-470	78	39	37	37	NUM
admet-470	78	40	°	°	NOUN
admet-470	78	41	c	c	NOUN
admet-470	78	42	for	for	ADP
admet-470	78	43	up	up	ADP
admet-470	78	44	to	to	PART
admet-470	78	45	120	120	NUM
admet-470	78	46	min	min	NOUN
admet-470	78	47	as	as	SCONJ
admet-470	78	48	described	describe	VERB
admet-470	78	49	earlier	early	ADV
admet-470	78	50	[	[	X
admet-470	78	51	26	26	NUM
admet-470	78	52	,	,	PUNCT
admet-470	78	53	31	31	NUM
admet-470	78	54	,	,	PUNCT
admet-470	78	55	32	32	NUM
admet-470	78	56	]	]	PUNCT
admet-470	78	57	.	.	PUNCT
admet-470	79	1	it	it	PRON
admet-470	79	2	is	be	AUX
admet-470	79	3	updated	update	VERB
admet-470	79	4	about	about	ADP
admet-470	79	5	every	every	DET
admet-470	79	6	sixth	sixth	ADJ
admet-470	79	7	month	month	NOUN
admet-470	79	8	.	.	PUNCT
admet-470	80	1	the	the	DET
admet-470	80	2	present	present	ADJ
admet-470	80	3	training	training	NOUN
admet-470	80	4	set	set	NOUN
admet-470	80	5	contains	contain	VERB
admet-470	80	6	more	more	ADJ
admet-470	80	7	than	than	ADP
admet-470	80	8	11,000	11,000	NUM
admet-470	80	9	compounds	compound	NOUN
admet-470	80	10	and	and	CCONJ
admet-470	80	11	the	the	DET
admet-470	80	12	data	data	NOUN
admet-470	80	13	is	be	AUX
admet-470	80	14	modelled	model	VERB
admet-470	80	15	as	as	ADP
admet-470	80	16	log	log	PROPN
admet-470	80	17	clint	clint	NOUN
admet-470	80	18	.	.	PUNCT
admet-470	81	1	the	the	DET
admet-470	81	2	modelling	model	VERB
admet-470	81	3	procedure	procedure	NOUN
admet-470	81	4	utilizes	utilize	VERB
admet-470	81	5	support	support	NOUN
admet-470	81	6	vector	vector	NOUN
admet-470	81	7	machines	machine	NOUN
admet-470	81	8	[	[	X
admet-470	81	9	27	27	NUM
admet-470	81	10	]	]	PUNCT
admet-470	81	11	with	with	ADP
admet-470	81	12	a	a	DET
admet-470	81	13	linear	linear	ADJ
admet-470	81	14	kernel	kernel	NOUN
admet-470	81	15	,	,	PUNCT
admet-470	81	16	signature	signature	NOUN
admet-470	81	17	descriptors	descriptor	NOUN
admet-470	81	18	[	[	X
admet-470	81	19	28	28	NUM
admet-470	81	20	]	]	PUNCT
admet-470	81	21	and	and	CCONJ
admet-470	81	22	the	the	DET
admet-470	81	23	conformal	conformal	ADJ
admet-470	81	24	prediction	prediction	NOUN
admet-470	81	25	framework	framework	NOUN
admet-470	81	26	[	[	X
admet-470	81	27	29	29	NUM
admet-470	81	28	]	]	PUNCT
admet-470	81	29	as	as	SCONJ
admet-470	81	30	implemented	implement	VERB
admet-470	81	31	in	in	ADP
admet-470	81	32	cpsign	cpsign	NOUN
admet-470	81	33	from	from	ADP
admet-470	81	34	genettasoft	genettasoft	NOUN
admet-470	81	35	[	[	X
admet-470	81	36	30	30	NUM
admet-470	81	37	]	]	PUNCT
admet-470	81	38	.	.	PUNCT
admet-470	82	1	the	the	DET
admet-470	82	2	latest	late	ADJ
admet-470	82	3	temporal	temporal	ADJ
admet-470	82	4	test	test	NOUN
admet-470	82	5	set	set	NOUN
admet-470	82	6	comprising	comprise	VERB
admet-470	82	7	almost	almost	ADV
admet-470	82	8	200	200	NUM
admet-470	82	9	compounds	compound	NOUN
admet-470	82	10	shows	show	VERB
admet-470	82	11	an	an	DET
admet-470	82	12	r2	r2	NOUN
admet-470	82	13	of	of	ADP
admet-470	82	14	0.2	0.2	NUM
admet-470	82	15	and	and	CCONJ
admet-470	82	16	an	an	DET
admet-470	82	17	rmsep	rmsep	NOUN
admet-470	82	18	of	of	ADP
admet-470	82	19	0.4	0.4	NUM
admet-470	82	20	,	,	PUNCT
admet-470	82	21	with	with	ADP
admet-470	82	22	~75	~75	PUNCT
admet-470	82	23	%	%	NOUN
admet-470	82	24	of	of	ADP
admet-470	82	25	the	the	DET
admet-470	82	26	compounds	compound	NOUN
admet-470	82	27	being	be	AUX
admet-470	82	28	within	within	ADP
admet-470	82	29	3	3	NOUN
admet-470	82	30	-	-	ADJ
admet-470	82	31	fold	fold	NOUN
admet-470	82	32	of	of	ADP
admet-470	82	33	the	the	DET
admet-470	82	34	experimental	experimental	ADJ
admet-470	82	35	clint	clint	NOUN
admet-470	82	36	value	value	NOUN
admet-470	82	37	.	.	PUNCT
admet-470	83	1	5	5	X
admet-470	83	2	.	.	X
admet-470	83	3	fraction	fraction	NOUN
admet-470	83	4	unbound	unbound	NOUN
admet-470	83	5	in	in	ADP
admet-470	83	6	the	the	DET
admet-470	83	7	hepatocyte	hepatocyte	NOUN
admet-470	83	8	incubation	incubation	NOUN
admet-470	83	9	(	(	PUNCT
admet-470	83	10	fuinc	fuinc	PROPN
admet-470	83	11	)	)	PUNCT
admet-470	83	12	the	the	DET
admet-470	83	13	model	model	NOUN
admet-470	83	14	is	be	AUX
admet-470	83	15	built	build	VERB
admet-470	83	16	on	on	ADP
admet-470	83	17	in	in	ADP
admet-470	83	18	-	-	PUNCT
admet-470	83	19	house	house	NOUN
admet-470	83	20	binding	bind	VERB
admet-470	83	21	data	datum	NOUN
admet-470	83	22	measured	measure	VERB
admet-470	83	23	in	in	ADP
admet-470	83	24	cryopreserved	cryopreserved	ADJ
admet-470	83	25	rat	rat	NOUN
admet-470	83	26	hepatocyte	hepatocyte	NOUN
admet-470	83	27	incubations	incubation	NOUN
admet-470	83	28	as	as	SCONJ
admet-470	83	29	described	describe	VERB
admet-470	83	30	earlier	early	ADV
admet-470	83	31	[	[	X
admet-470	83	32	33	33	NUM
admet-470	83	33	]	]	PUNCT
admet-470	83	34	.	.	PUNCT
admet-470	84	1	the	the	DET
admet-470	84	2	model	model	NOUN
admet-470	84	3	is	be	AUX
admet-470	84	4	updated	update	VERB
admet-470	84	5	approximately	approximately	ADV
admet-470	84	6	every	every	DET
admet-470	84	7	sixth	sixth	ADJ
admet-470	84	8	month	month	NOUN
admet-470	84	9	and	and	CCONJ
admet-470	84	10	the	the	DET
admet-470	84	11	present	present	ADJ
admet-470	84	12	data	datum	NOUN
admet-470	84	13	set	set	VERB
admet-470	84	14	contains	contain	VERB
admet-470	84	15	about	about	ADP
admet-470	84	16	1,700	1,700	NUM
admet-470	84	17	compounds	compound	NOUN
admet-470	84	18	.	.	PUNCT
admet-470	85	1	the	the	DET
admet-470	85	2	data	data	NOUN
admet-470	85	3	is	be	AUX
admet-470	85	4	modelled	model	VERB
admet-470	85	5	as	as	ADP
admet-470	85	6	log	log	PROPN
admet-470	85	7	k	k	PROPN
admet-470	85	8	(=	(=	X
admet-470	85	9	log[(fraction	log[(fraction	PROPN
admet-470	85	10	unbound)/(fraction	unbound)/(fraction	PROPN
admet-470	85	11	admet	admet	PROPN
admet-470	85	12	&	&	CCONJ
admet-470	85	13	dmpk	dmpk	PROPN
admet-470	85	14	6(1	6(1	NUM
admet-470	85	15	)	)	PUNCT
admet-470	85	16	(	(	PUNCT
admet-470	85	17	2018	2018	NUM
admet-470	85	18	)	)	PUNCT
admet-470	85	19	15	15	NUM
admet-470	85	20	-	-	SYM
admet-470	85	21	33	33	NUM
admet-470	85	22	in	in	ADP
admet-470	85	23	silico	silico	NOUN
admet-470	85	24	adme	adme	NOUN
admet-470	85	25	in	in	ADP
admet-470	85	26	drug	drug	NOUN
admet-470	85	27	design	design	NOUN
admet-470	85	28	doi	doi	NOUN
admet-470	85	29	:	:	PUNCT
admet-470	85	30	10.5599	10.5599	NUM
admet-470	85	31	/	/	SYM
admet-470	85	32	admet.6.1.470	admet.6.1.470	X
admet-470	85	33	19	19	NUM
admet-470	85	34	bound	bind	VERB
admet-470	85	35	)	)	PUNCT
admet-470	85	36	]	]	PUNCT
admet-470	85	37	)	)	PUNCT
admet-470	85	38	.	.	PUNCT
admet-470	86	1	the	the	DET
admet-470	86	2	modelling	model	VERB
admet-470	86	3	procedure	procedure	NOUN
admet-470	86	4	utilizes	utilize	VERB
admet-470	86	5	support	support	NOUN
admet-470	86	6	vector	vector	NOUN
admet-470	86	7	machines	machine	NOUN
admet-470	86	8	[	[	X
admet-470	86	9	27	27	NUM
admet-470	86	10	]	]	PUNCT
admet-470	86	11	with	with	ADP
admet-470	86	12	a	a	DET
admet-470	86	13	radial	radial	ADJ
admet-470	86	14	basis	basis	NOUN
admet-470	86	15	function	function	NOUN
admet-470	86	16	kernel	kernel	NOUN
admet-470	86	17	,	,	PUNCT
admet-470	86	18	signature	signature	NOUN
admet-470	86	19	descriptors	descriptor	NOUN
admet-470	86	20	[	[	X
admet-470	86	21	28	28	NUM
admet-470	86	22	]	]	PUNCT
admet-470	86	23	and	and	CCONJ
admet-470	86	24	the	the	DET
admet-470	86	25	conformal	conformal	ADJ
admet-470	86	26	prediction	prediction	NOUN
admet-470	86	27	framework	framework	NOUN
admet-470	86	28	[	[	X
admet-470	86	29	29	29	NUM
admet-470	86	30	]	]	PUNCT
admet-470	86	31	as	as	SCONJ
admet-470	86	32	implemented	implement	VERB
admet-470	86	33	in	in	ADP
admet-470	86	34	cpsign	cpsign	NOUN
admet-470	86	35	from	from	ADP
admet-470	86	36	genettasoft	genettasoft	NOUN
admet-470	86	37	[	[	X
admet-470	86	38	30	30	NUM
admet-470	86	39	]	]	PUNCT
admet-470	86	40	.	.	PUNCT
admet-470	87	1	the	the	DET
admet-470	87	2	latest	late	ADJ
admet-470	87	3	temporal	temporal	ADJ
admet-470	87	4	test	test	NOUN
admet-470	87	5	set	set	NOUN
admet-470	87	6	comprising	comprise	VERB
admet-470	87	7	about	about	ADV
admet-470	87	8	200	200	NUM
admet-470	87	9	compounds	compound	NOUN
admet-470	87	10	shows	show	VERB
admet-470	87	11	an	an	DET
admet-470	87	12	r2	r2	NOUN
admet-470	87	13	of	of	ADP
admet-470	87	14	0.5	0.5	NUM
admet-470	87	15	and	and	CCONJ
admet-470	87	16	an	an	DET
admet-470	87	17	rmsep	rmsep	NOUN
admet-470	87	18	of	of	ADP
admet-470	87	19	0.5	0.5	NUM
admet-470	87	20	,	,	PUNCT
admet-470	87	21	with	with	ADP
admet-470	87	22	~75	~75	PUNCT
admet-470	87	23	%	%	NOUN
admet-470	87	24	of	of	ADP
admet-470	87	25	the	the	DET
admet-470	87	26	compounds	compound	NOUN
admet-470	87	27	being	be	AUX
admet-470	87	28	within	within	ADP
admet-470	87	29	3	3	NOUN
admet-470	87	30	-	-	ADJ
admet-470	87	31	fold	fold	NOUN
admet-470	87	32	of	of	ADP
admet-470	87	33	the	the	DET
admet-470	87	34	experimental	experimental	ADJ
admet-470	87	35	fuinc	fuinc	PROPN
admet-470	87	36	value	value	NOUN
admet-470	87	37	.	.	PUNCT
admet-470	88	1	global	global	ADJ
admet-470	88	2	sensitivity	sensitivity	NOUN
admet-470	88	3	analysis	analysis	NOUN
admet-470	88	4	global	global	ADJ
admet-470	88	5	sensitivity	sensitivity	NOUN
admet-470	88	6	analysis	analysis	NOUN
admet-470	88	7	was	be	AUX
admet-470	88	8	performed	perform	VERB
admet-470	88	9	by	by	ADP
admet-470	88	10	a	a	DET
admet-470	88	11	quasi	quasi	ADJ
admet-470	88	12	-	-	ADJ
admet-470	88	13	monte	monte	ADJ
admet-470	88	14	carlo	carlo	NOUN
admet-470	88	15	method	method	NOUN
admet-470	88	16	using	use	VERB
admet-470	88	17	the	the	DET
admet-470	88	18	fourier	fourier	ADJ
admet-470	88	19	amplitude	amplitude	NOUN
admet-470	88	20	sensitivity	sensitivity	NOUN
admet-470	88	21	test	test	NOUN
admet-470	88	22	(	(	PUNCT
admet-470	88	23	fast	fast	ADJ
admet-470	88	24	)	)	PUNCT
admet-470	88	25	and	and	CCONJ
admet-470	88	26	sobol	sobol	ADJ
admet-470	88	27	’	'	PUNCT
admet-470	88	28	sensitivity	sensitivity	NOUN
admet-470	88	29	,	,	PUNCT
admet-470	88	30	which	which	PRON
admet-470	88	31	are	be	AUX
admet-470	88	32	implemented	implement	VERB
admet-470	88	33	in	in	ADP
admet-470	88	34	the	the	DET
admet-470	88	35	global	global	ADJ
admet-470	88	36	sensitivity	sensitivity	NOUN
admet-470	88	37	analysis	analysis	NOUN
admet-470	88	38	toolbox	toolbox	NOUN
admet-470	88	39	(	(	PUNCT
admet-470	88	40	gsat	gsat	PROPN
admet-470	88	41	)	)	PUNCT
admet-470	89	1	[	[	X
admet-470	89	2	34	34	NUM
admet-470	89	3	]	]	PUNCT
admet-470	89	4	in	in	ADP
admet-470	89	5	matlab	matlab	PROPN
admet-470	90	1	[	[	X
admet-470	90	2	35	35	NUM
admet-470	90	3	]	]	PUNCT
admet-470	90	4	using	use	VERB
admet-470	90	5	20,000	20,000	NUM
admet-470	90	6	sample	sample	NOUN
admet-470	90	7	points	point	NOUN
admet-470	90	8	.	.	PUNCT
admet-470	91	1	local	local	ADJ
admet-470	91	2	sensitivity	sensitivity	NOUN
admet-470	91	3	analysis	analysis	NOUN
admet-470	91	4	local	local	ADJ
admet-470	91	5	sensitivity	sensitivity	NOUN
admet-470	91	6	analysis	analysis	NOUN
admet-470	91	7	was	be	AUX
admet-470	91	8	performed	perform	VERB
admet-470	91	9	by	by	ADP
admet-470	91	10	taking	take	VERB
admet-470	91	11	jacobian	jacobian	ADJ
admet-470	91	12	matrices	matrix	NOUN
admet-470	91	13	of	of	ADP
admet-470	91	14	the	the	DET
admet-470	91	15	model	model	NOUN
admet-470	91	16	with	with	ADP
admet-470	91	17	respect	respect	NOUN
admet-470	91	18	to	to	ADP
admet-470	91	19	the	the	DET
admet-470	91	20	model	model	NOUN
admet-470	91	21	parameters	parameter	NOUN
admet-470	91	22	and	and	CCONJ
admet-470	91	23	other	other	ADJ
admet-470	91	24	parameter	parameter	NOUN
admet-470	91	25	points	point	NOUN
admet-470	92	1	[	[	X
admet-470	92	2	36	36	NUM
admet-470	92	3	]	]	PUNCT
admet-470	92	4	.	.	PUNCT
admet-470	93	1	these	these	DET
admet-470	93	2	matrices	matrix	NOUN
admet-470	93	3	contain	contain	VERB
admet-470	93	4	actual	actual	ADJ
admet-470	93	5	parameter	parameter	NOUN
admet-470	93	6	values	value	NOUN
admet-470	93	7	which	which	PRON
admet-470	93	8	can	can	AUX
admet-470	93	9	be	be	AUX
admet-470	93	10	examined	examine	VERB
admet-470	93	11	,	,	PUNCT
admet-470	93	12	or	or	CCONJ
admet-470	93	13	plotted	plot	VERB
admet-470	93	14	graphically	graphically	ADV
admet-470	93	15	against	against	ADP
admet-470	93	16	other	other	ADJ
admet-470	93	17	parameters	parameter	NOUN
admet-470	93	18	,	,	PUNCT
admet-470	93	19	to	to	PART
admet-470	93	20	show	show	VERB
admet-470	93	21	which	which	PRON
admet-470	93	22	have	have	VERB
admet-470	93	23	the	the	DET
admet-470	93	24	greatest	great	ADJ
admet-470	93	25	effect	effect	NOUN
admet-470	93	26	at	at	ADP
admet-470	93	27	each	each	DET
admet-470	93	28	point	point	NOUN
admet-470	93	29	.	.	PUNCT
admet-470	94	1	𝑆(𝑞	𝑆(𝑞	NOUN
admet-470	94	2	,	,	PUNCT
admet-470	94	3	𝑝	𝑝	NOUN
admet-470	94	4	)	)	PUNCT
admet-470	94	5	=	=	SYM
admet-470	94	6	(	(	PUNCT
admet-470	94	7	𝜕𝑥(𝑞1,𝑝	𝜕𝑥(𝑞1,𝑝	NOUN
admet-470	94	8	)	)	PUNCT
admet-470	94	9	𝜕𝑝1	𝜕𝑝1	PROPN
admet-470	94	10	⋯	⋯	ADP
admet-470	94	11	𝜕𝑥(𝑞,𝑝	𝜕𝑥(𝑞,𝑝	NOUN
admet-470	94	12	)	)	PUNCT
admet-470	95	1	𝜕𝑝𝑛	𝜕𝑝𝑛	ADJ
admet-470	95	2	⋮	⋮	NOUN
admet-470	95	3	⋱	⋱	PUNCT
admet-470	95	4	⋮	⋮	NOUN
admet-470	95	5	𝜕𝑥(𝑞𝑚,𝑝	𝜕𝑥(𝑞𝑚,𝑝	NOUN
admet-470	95	6	)	)	PUNCT
admet-470	95	7	𝜕𝑝1	𝜕𝑝1	PROPN
admet-470	95	8	⋯	⋯	ADP
admet-470	95	9	𝜕𝑥(𝑞𝑚,𝑝	𝜕𝑥(𝑞𝑚,𝑝	NOUN
admet-470	95	10	)	)	PUNCT
admet-470	95	11	𝜕𝑝𝑛	𝜕𝑝𝑛	CCONJ
admet-470	95	12	)	)	PUNCT
admet-470	95	13	,	,	PUNCT
admet-470	95	14	(	(	PUNCT
admet-470	95	15	11	11	NUM
admet-470	95	16	)	)	PUNCT
admet-470	95	17	where	where	SCONJ
admet-470	95	18	𝑞	𝑞	X
admet-470	95	19	=	=	PRON
admet-470	95	20	(	(	PUNCT
admet-470	95	21	𝑞1	𝑞1	PROPN
admet-470	95	22	,	,	PUNCT
admet-470	95	23	…	…	PUNCT
admet-470	95	24	,	,	PUNCT
admet-470	95	25	𝑞𝑚	𝑞𝑚	NOUN
admet-470	95	26	)	)	PUNCT
admet-470	95	27	is	be	AUX
admet-470	95	28	a	a	DET
admet-470	95	29	vector	vector	NOUN
admet-470	95	30	of	of	ADP
admet-470	95	31	parameter	parameter	NOUN
admet-470	95	32	points	point	NOUN
admet-470	95	33	to	to	PART
admet-470	95	34	be	be	AUX
admet-470	95	35	examined	examine	VERB
admet-470	95	36	,	,	PUNCT
admet-470	95	37	𝑝	𝑝	NOUN
admet-470	95	38	=	=	SYM
admet-470	95	39	(	(	PUNCT
admet-470	95	40	𝑝1	𝑝1	NOUN
admet-470	95	41	,	,	PUNCT
admet-470	95	42	…	…	PUNCT
admet-470	95	43	,	,	PUNCT
admet-470	95	44	𝑝𝑛	𝑝𝑛	PROPN
admet-470	95	45	)	)	PUNCT
admet-470	95	46	is	be	AUX
admet-470	95	47	a	a	DET
admet-470	95	48	vector	vector	NOUN
admet-470	95	49	of	of	ADP
admet-470	95	50	other	other	ADJ
admet-470	95	51	parameters	parameter	NOUN
admet-470	95	52	which	which	PRON
admet-470	95	53	are	be	AUX
admet-470	95	54	being	be	AUX
admet-470	95	55	examined	examine	VERB
admet-470	95	56	,	,	PUNCT
admet-470	95	57	and	and	CCONJ
admet-470	95	58	x	x	X
admet-470	95	59	is	be	AUX
admet-470	95	60	a	a	DET
admet-470	95	61	scalar	scalar	ADJ
admet-470	95	62	output	output	NOUN
admet-470	95	63	from	from	ADP
admet-470	95	64	the	the	DET
admet-470	95	65	model	model	NOUN
admet-470	95	66	.	.	PUNCT
admet-470	96	1	this	this	PRON
admet-470	96	2	was	be	AUX
admet-470	96	3	performed	perform	VERB
admet-470	96	4	in	in	ADP
admet-470	96	5	matlab	matlab	PROPN
admet-470	96	6	[	[	X
admet-470	96	7	35	35	NUM
admet-470	96	8	]	]	PUNCT
admet-470	96	9	using	use	VERB
admet-470	96	10	automatic	automatic	ADJ
admet-470	96	11	differentiation	differentiation	NOUN
admet-470	96	12	of	of	ADP
admet-470	96	13	the	the	DET
admet-470	96	14	parameters	parameter	NOUN
admet-470	96	15	via	via	ADP
admet-470	96	16	the	the	DET
admet-470	96	17	myad	myad	NOUN
admet-470	96	18	toolkit	toolkit	NOUN
admet-470	97	1	[	[	X
admet-470	97	2	37	37	NUM
admet-470	97	3	]	]	PUNCT
admet-470	97	4	.	.	PUNCT
admet-470	98	1	data	datum	NOUN
admet-470	98	2	sets	set	VERB
admet-470	98	3	two	two	NUM
admet-470	98	4	data	data	NOUN
admet-470	98	5	sets	set	NOUN
admet-470	98	6	were	be	AUX
admet-470	98	7	used	use	VERB
admet-470	98	8	for	for	ADP
admet-470	98	9	the	the	DET
admet-470	98	10	present	present	ADJ
admet-470	98	11	analysis	analysis	NOUN
admet-470	98	12	.	.	PUNCT
admet-470	99	1	data	datum	NOUN
admet-470	99	2	set	set	VERB
admet-470	99	3	1	1	NUM
admet-470	99	4	was	be	AUX
admet-470	99	5	a	a	DET
admet-470	99	6	set	set	NOUN
admet-470	99	7	of	of	ADP
admet-470	99	8	27	27	NUM
admet-470	99	9	drug	drug	NOUN
admet-470	99	10	discovery	discovery	NOUN
admet-470	99	11	compounds	compound	NOUN
admet-470	99	12	exemplifying	exemplify	VERB
admet-470	99	13	important	important	ADJ
admet-470	99	14	compounds	compound	NOUN
admet-470	99	15	leading	lead	VERB
admet-470	99	16	towards	towards	ADP
admet-470	99	17	candidate	candidate	NOUN
admet-470	99	18	selection	selection	NOUN
admet-470	99	19	[	[	X
admet-470	99	20	11	11	NUM
admet-470	99	21	]	]	PUNCT
admet-470	99	22	.	.	PUNCT
admet-470	100	1	data	datum	NOUN
admet-470	100	2	set	set	VERB
admet-470	100	3	2	2	NUM
admet-470	100	4	was	be	AUX
admet-470	100	5	a	a	DET
admet-470	100	6	set	set	NOUN
admet-470	100	7	of	of	ADP
admet-470	100	8	21	21	NUM
admet-470	100	9	marketed	market	VERB
admet-470	100	10	drugs	drug	NOUN
admet-470	100	11	,	,	PUNCT
admet-470	100	12	for	for	ADP
admet-470	100	13	which	which	PRON
admet-470	100	14	potency	potency	NOUN
admet-470	100	15	data	datum	NOUN
admet-470	100	16	,	,	PUNCT
admet-470	100	17	dosing	dose	VERB
admet-470	100	18	information	information	NOUN
admet-470	100	19	and	and	CCONJ
admet-470	100	20	human	human	ADJ
admet-470	100	21	pharmacokinetic	pharmacokinetic	ADJ
admet-470	100	22	data	datum	NOUN
admet-470	100	23	had	have	AUX
admet-470	100	24	been	be	AUX
admet-470	100	25	collated	collate	VERB
admet-470	100	26	and	and	CCONJ
admet-470	100	27	used	use	VERB
admet-470	100	28	to	to	PART
admet-470	100	29	show	show	VERB
admet-470	100	30	feasibility	feasibility	NOUN
admet-470	100	31	of	of	ADP
admet-470	100	32	early	early	ADJ
admet-470	100	33	d2	d2	PROPN
admet-470	100	34	m	m	NOUN
admet-470	100	35	predictions	prediction	NOUN
admet-470	100	36	[	[	X
admet-470	100	37	9	9	NUM
admet-470	100	38	]	]	PUNCT
admet-470	100	39	.	.	PUNCT
admet-470	101	1	susanne	susanne	PROPN
admet-470	101	2	winiwarter	winiwarter	PROPN
admet-470	101	3	et	et	PROPN
admet-470	101	4	al	al	PROPN
admet-470	101	5	.	.	PROPN
admet-470	101	6	admet	admet	PROPN
admet-470	101	7	&	&	CCONJ
admet-470	101	8	dmpk	dmpk	PROPN
admet-470	101	9	6(1	6(1	NUM
admet-470	101	10	)	)	PUNCT
admet-470	101	11	(	(	PUNCT
admet-470	101	12	2018	2018	NUM
admet-470	101	13	)	)	PUNCT
admet-470	101	14	15	15	NUM
admet-470	101	15	-	-	SYM
admet-470	101	16	33	33	NUM
admet-470	101	17	20	20	NUM
admet-470	101	18	results	result	NOUN
admet-470	101	19	and	and	CCONJ
admet-470	101	20	discussion	discussion	NOUN
admet-470	101	21	calculation	calculation	NOUN
admet-470	101	22	of	of	ADP
admet-470	101	23	required	require	VERB
admet-470	101	24	minimum	minimum	ADJ
admet-470	101	25	potency	potency	NOUN
admet-470	101	26	(	(	PUNCT
admet-470	101	27	threshold	threshold	NOUN
admet-470	101	28	pic50	pic50	NOUN
admet-470	101	29	)	)	PUNCT
admet-470	101	30	for	for	ADP
admet-470	101	31	a	a	DET
admet-470	101	32	set	set	NOUN
admet-470	101	33	of	of	ADP
admet-470	101	34	drug	drug	NOUN
admet-470	101	35	discovery	discovery	NOUN
admet-470	101	36	compounds	compound	NOUN
admet-470	101	37	as	as	ADP
admet-470	101	38	proof	proof	NOUN
admet-470	101	39	of	of	ADP
admet-470	101	40	concept	concept	NOUN
admet-470	101	41	a	a	DET
admet-470	101	42	set	set	NOUN
admet-470	101	43	of	of	ADP
admet-470	101	44	drug	drug	NOUN
admet-470	101	45	discovery	discovery	NOUN
admet-470	101	46	molecules	molecule	NOUN
admet-470	101	47	leading	lead	VERB
admet-470	101	48	towards	towards	ADP
admet-470	101	49	a	a	DET
admet-470	101	50	candidate	candidate	NOUN
admet-470	101	51	structure	structure	NOUN
admet-470	101	52	[	[	X
admet-470	101	53	11	11	NUM
admet-470	101	54	]	]	PUNCT
admet-470	101	55	was	be	AUX
admet-470	101	56	evaluated	evaluate	VERB
admet-470	101	57	.	.	PUNCT
admet-470	102	1	intrinsic	intrinsic	ADJ
admet-470	102	2	clearance	clearance	NOUN
admet-470	102	3	in	in	ADP
admet-470	102	4	human	human	ADJ
admet-470	102	5	hepatocytes	hepatocyte	NOUN
admet-470	102	6	,	,	PUNCT
admet-470	102	7	fraction	fraction	NOUN
admet-470	102	8	unbound	unbound	NOUN
admet-470	102	9	in	in	ADP
admet-470	102	10	the	the	DET
admet-470	102	11	incubation	incubation	NOUN
admet-470	102	12	,	,	PUNCT
admet-470	102	13	fraction	fraction	NOUN
admet-470	102	14	unbound	unbound	NOUN
admet-470	102	15	in	in	ADP
admet-470	102	16	plasma	plasma	NOUN
admet-470	102	17	,	,	PUNCT
admet-470	102	18	volume	volume	NOUN
admet-470	102	19	of	of	ADP
admet-470	102	20	distribution	distribution	NOUN
admet-470	102	21	and	and	CCONJ
admet-470	102	22	intrinsic	intrinsic	ADJ
admet-470	102	23	caco2	caco2	NOUN
admet-470	102	24	permeability	permeability	NOUN
admet-470	102	25	were	be	AUX
admet-470	102	26	predicted	predict	VERB
admet-470	102	27	for	for	ADP
admet-470	102	28	all	all	DET
admet-470	102	29	compounds	compound	NOUN
admet-470	102	30	using	use	VERB
admet-470	102	31	the	the	DET
admet-470	102	32	present	present	ADJ
admet-470	102	33	in	in	ADP
admet-470	102	34	-	-	PUNCT
admet-470	102	35	house	house	NOUN
admet-470	102	36	models	model	NOUN
admet-470	102	37	(	(	PUNCT
admet-470	102	38	see	see	VERB
admet-470	102	39	table	table	NOUN
admet-470	102	40	1	1	NUM
admet-470	102	41	)	)	PUNCT
admet-470	102	42	and	and	CCONJ
admet-470	102	43	minimum	minimum	NOUN
admet-470	102	44	and	and	CCONJ
admet-470	102	45	maximum	maximum	ADJ
admet-470	102	46	plasma	plasma	NOUN
admet-470	102	47	concentrations	concentration	NOUN
admet-470	102	48	for	for	ADP
admet-470	102	49	a	a	DET
admet-470	102	50	once	once	ADV
admet-470	102	51	daily	daily	ADJ
admet-470	102	52	oral	oral	ADJ
admet-470	102	53	dose	dose	NOUN
admet-470	102	54	of	of	ADP
admet-470	102	55	100	100	NUM
admet-470	102	56	mg	mg	NOUN
admet-470	102	57	calculated	calculate	VERB
admet-470	102	58	using	use	VERB
admet-470	102	59	equations	equation	NOUN
admet-470	102	60	2	2	NUM
admet-470	102	61	and	and	CCONJ
admet-470	102	62	3	3	NUM
admet-470	102	63	.	.	PUNCT
admet-470	103	1	the	the	DET
admet-470	103	2	project	project	NOUN
admet-470	103	3	aimed	aim	VERB
admet-470	103	4	at	at	ADP
admet-470	103	5	minimum	minimum	ADJ
admet-470	103	6	plasma	plasma	NOUN
admet-470	103	7	concentrations	concentration	NOUN
admet-470	103	8	with	with	ADP
admet-470	103	9	3	3	ADJ
admet-470	103	10	-	-	ADJ
admet-470	103	11	fold	fold	ADJ
admet-470	103	12	coverage	coverage	NOUN
admet-470	103	13	over	over	ADP
admet-470	103	14	potency	potency	NOUN
admet-470	103	15	measured	measure	VERB
admet-470	103	16	as	as	ADP
admet-470	103	17	pic50	pic50	NOUN
admet-470	103	18	in	in	ADP
admet-470	103	19	a	a	DET
admet-470	103	20	whole	whole	ADJ
admet-470	103	21	blood	blood	NOUN
admet-470	103	22	assay	assay	VERB
admet-470	103	23	.	.	PUNCT
admet-470	104	1	thus	thus	ADV
admet-470	104	2	,	,	PUNCT
admet-470	104	3	threshold	threshold	VERB
admet-470	104	4	pic50	pic50	NOUN
admet-470	104	5	values	value	NOUN
admet-470	104	6	were	be	AUX
admet-470	104	7	calculated	calculate	VERB
admet-470	104	8	from	from	ADP
admet-470	104	9	cmin	cmin	NOUN
admet-470	104	10	,	,	PUNCT
admet-470	104	11	total/3	total/3	PROPN
admet-470	104	12	(	(	PUNCT
admet-470	104	13	see	see	VERB
admet-470	104	14	table	table	NOUN
admet-470	104	15	2	2	NUM
admet-470	104	16	)	)	PUNCT
admet-470	104	17	.	.	PUNCT
admet-470	105	1	blood	blood	NOUN
admet-470	105	2	plasma	plasma	NOUN
admet-470	105	3	ratios	ratio	NOUN
admet-470	105	4	for	for	ADP
admet-470	105	5	these	these	DET
admet-470	105	6	mainly	mainly	ADV
admet-470	105	7	neutral	neutral	ADJ
admet-470	105	8	compounds	compound	NOUN
admet-470	105	9	were	be	AUX
admet-470	105	10	considered	consider	VERB
admet-470	105	11	to	to	PART
admet-470	105	12	be	be	AUX
admet-470	105	13	1	1	NUM
admet-470	105	14	.	.	PUNCT
admet-470	106	1	protein	protein	NOUN
admet-470	106	2	binding	bind	VERB
admet-470	106	3	was	be	AUX
admet-470	106	4	considered	consider	VERB
admet-470	106	5	in	in	ADP
admet-470	106	6	the	the	DET
admet-470	106	7	scaling	scaling	NOUN
admet-470	106	8	approach	approach	NOUN
admet-470	106	9	,	,	PUNCT
admet-470	106	10	but	but	CCONJ
admet-470	106	11	threshold	threshold	NOUN
admet-470	106	12	pic50s	pic50	NOUN
admet-470	106	13	were	be	AUX
admet-470	106	14	based	base	VERB
admet-470	106	15	on	on	ADP
admet-470	106	16	resulting	result	VERB
admet-470	106	17	total	total	ADJ
admet-470	106	18	plasma	plasma	NOUN
admet-470	106	19	concentration	concentration	NOUN
admet-470	106	20	to	to	PART
admet-470	106	21	match	match	VERB
admet-470	106	22	the	the	DET
admet-470	106	23	potency	potency	NOUN
admet-470	106	24	measurement	measurement	NOUN
admet-470	106	25	.	.	PUNCT
admet-470	107	1	the	the	DET
admet-470	107	2	data	datum	NOUN
admet-470	107	3	indicated	indicate	VERB
admet-470	107	4	that	that	SCONJ
admet-470	107	5	some	some	PRON
admet-470	107	6	of	of	ADP
admet-470	107	7	the	the	DET
admet-470	107	8	compounds	compound	NOUN
admet-470	107	9	had	have	VERB
admet-470	107	10	very	very	ADV
admet-470	107	11	short	short	ADJ
admet-470	107	12	half	half	ADJ
admet-470	107	13	-	-	PUNCT
admet-470	107	14	life	life	NOUN
admet-470	107	15	and	and	CCONJ
admet-470	107	16	thus	thus	ADV
admet-470	107	17	a	a	DET
admet-470	107	18	once	once	ADV
admet-470	107	19	daily	daily	ADJ
admet-470	107	20	dose	dose	NOUN
admet-470	107	21	resulted	result	VERB
admet-470	107	22	in	in	ADP
admet-470	107	23	a	a	DET
admet-470	107	24	high	high	ADJ
admet-470	107	25	threshold	threshold	NOUN
admet-470	107	26	pic50	pic50	NOUN
admet-470	107	27	to	to	PART
admet-470	107	28	cover	cover	VERB
admet-470	107	29	potency	potency	NOUN
admet-470	107	30	over	over	ADP
admet-470	107	31	24	24	NUM
admet-470	107	32	hours	hour	NOUN
admet-470	107	33	and	and	CCONJ
admet-470	107	34	a	a	DET
admet-470	107	35	high	high	ADJ
admet-470	107	36	cmax	cmax	NOUN
admet-470	107	37	/	/	SYM
admet-470	107	38	cmin	cmin	NOUN
admet-470	107	39	ratio	ratio	NOUN
admet-470	107	40	.	.	PUNCT
admet-470	108	1	using	use	VERB
admet-470	108	2	a	a	DET
admet-470	108	3	10	10	NUM
admet-470	108	4	times	time	NOUN
admet-470	108	5	higher	high	ADJ
admet-470	108	6	dose	dose	NOUN
admet-470	108	7	would	would	AUX
admet-470	108	8	reduce	reduce	VERB
admet-470	108	9	the	the	DET
admet-470	108	10	threshold	threshold	NOUN
admet-470	108	11	pic50	pic50	NOUN
admet-470	108	12	by	by	ADP
admet-470	108	13	one	one	NUM
admet-470	108	14	unit	unit	NOUN
admet-470	108	15	,	,	PUNCT
admet-470	108	16	but	but	CCONJ
admet-470	108	17	show	show	VERB
admet-470	108	18	the	the	DET
admet-470	108	19	same	same	ADJ
admet-470	108	20	cmax	cmax	NOUN
admet-470	108	21	/	/	SYM
admet-470	108	22	cmin	cmin	NOUN
admet-470	108	23	ratio	ratio	NOUN
admet-470	108	24	,	,	PUNCT
admet-470	108	25	since	since	SCONJ
admet-470	108	26	the	the	DET
admet-470	108	27	applied	apply	VERB
admet-470	108	28	model	model	NOUN
admet-470	108	29	assumes	assume	VERB
admet-470	108	30	linear	linear	PROPN
admet-470	108	31	kinetics	kinetic	NOUN
admet-470	108	32	.	.	PUNCT
admet-470	109	1	considering	consider	VERB
admet-470	109	2	only	only	ADJ
admet-470	109	3	compounds	compound	NOUN
admet-470	109	4	with	with	ADP
admet-470	109	5	a	a	DET
admet-470	109	6	threshold	threshold	NOUN
admet-470	109	7	pic50	pic50	NOUN
admet-470	109	8	below	below	ADP
admet-470	109	9	9	9	NUM
admet-470	109	10	and	and	CCONJ
admet-470	109	11	a	a	DET
admet-470	109	12	cmax	cmax	NOUN
admet-470	109	13	/	/	SYM
admet-470	109	14	cmin	cmin	NOUN
admet-470	109	15	ratio	ratio	NOUN
admet-470	109	16	below	below	ADP
admet-470	109	17	100	100	NUM
admet-470	109	18	about	about	ADV
admet-470	109	19	12	12	NUM
admet-470	109	20	compounds	compound	NOUN
admet-470	109	21	remained	remain	VERB
admet-470	109	22	.	.	PUNCT
admet-470	110	1	this	this	DET
admet-470	110	2	set	set	NOUN
admet-470	110	3	of	of	ADP
admet-470	110	4	compounds	compound	NOUN
admet-470	110	5	included	include	VERB
admet-470	110	6	compound	compound	NOUN
admet-470	110	7	15b	15b	NOUN
admet-470	110	8	,	,	PUNCT
admet-470	110	9	the	the	DET
admet-470	110	10	compound	compound	NOUN
admet-470	110	11	finally	finally	ADV
admet-470	110	12	selected	select	VERB
admet-470	110	13	,	,	PUNCT
admet-470	110	14	and	and	CCONJ
admet-470	110	15	three	three	NUM
admet-470	110	16	of	of	ADP
admet-470	110	17	the	the	DET
admet-470	110	18	remaining	remain	VERB
admet-470	110	19	four	four	NUM
admet-470	110	20	compounds	compound	NOUN
admet-470	110	21	of	of	ADP
admet-470	110	22	higher	high	ADJ
admet-470	110	23	interest	interest	NOUN
admet-470	110	24	for	for	ADP
admet-470	110	25	which	which	PRON
admet-470	110	26	rat	rat	NOUN
admet-470	110	27	in	in	ADP
admet-470	110	28	vivo	vivo	NOUN
admet-470	110	29	results	result	NOUN
admet-470	110	30	were	be	AUX
admet-470	110	31	reported	report	VERB
admet-470	110	32	.	.	PUNCT
admet-470	111	1	compound	compound	NOUN
admet-470	111	2	22	22	NUM
admet-470	111	3	,	,	PUNCT
admet-470	111	4	which	which	PRON
admet-470	111	5	according	accord	VERB
admet-470	111	6	to	to	ADP
admet-470	111	7	the	the	DET
admet-470	111	8	present	present	ADJ
admet-470	111	9	analysis	analysis	NOUN
admet-470	111	10	was	be	AUX
admet-470	111	11	least	least	ADV
admet-470	111	12	favourable	favourable	ADJ
admet-470	111	13	,	,	PUNCT
admet-470	111	14	was	be	AUX
admet-470	111	15	actually	actually	ADV
admet-470	111	16	found	find	VERB
admet-470	111	17	in	in	ADP
admet-470	111	18	the	the	DET
admet-470	111	19	rat	rat	NOUN
admet-470	111	20	study	study	NOUN
admet-470	111	21	to	to	PART
admet-470	111	22	have	have	VERB
admet-470	111	23	short	short	ADJ
admet-470	111	24	half	half	ADJ
admet-470	111	25	-	-	PUNCT
admet-470	111	26	life	life	NOUN
admet-470	111	27	and	and	CCONJ
admet-470	111	28	,	,	PUNCT
admet-470	111	29	thus	thus	ADV
admet-470	111	30	,	,	PUNCT
admet-470	111	31	not	not	PART
admet-470	111	32	suitable	suitable	ADJ
admet-470	111	33	to	to	AUX
admet-470	111	34	progress	progress	VERB
admet-470	111	35	.	.	PUNCT
admet-470	112	1	in	in	ADP
admet-470	112	2	summary	summary	NOUN
admet-470	112	3	,	,	PUNCT
admet-470	112	4	it	it	PRON
admet-470	112	5	seems	seem	VERB
admet-470	112	6	that	that	SCONJ
admet-470	112	7	for	for	SCONJ
admet-470	112	8	this	this	DET
admet-470	112	9	data	datum	NOUN
admet-470	112	10	set	set	VERB
admet-470	112	11	the	the	DET
admet-470	112	12	threshold	threshold	NOUN
admet-470	112	13	pic50	pic50	NOUN
admet-470	112	14	together	together	ADV
admet-470	112	15	with	with	ADP
admet-470	112	16	the	the	DET
admet-470	112	17	predicted	predict	VERB
admet-470	112	18	cmax	cmax	NOUN
admet-470	112	19	/	/	SYM
admet-470	112	20	cmin	cmin	NOUN
admet-470	112	21	ratio	ratio	NOUN
admet-470	112	22	could	could	AUX
admet-470	112	23	be	be	AUX
admet-470	112	24	used	use	VERB
admet-470	112	25	for	for	ADP
admet-470	112	26	ranking	rank	VERB
admet-470	112	27	the	the	DET
admet-470	112	28	compounds	compound	NOUN
admet-470	112	29	and	and	CCONJ
admet-470	112	30	correctly	correctly	ADV
admet-470	112	31	identify	identify	VERB
admet-470	112	32	those	those	PRON
admet-470	112	33	with	with	ADP
admet-470	112	34	inferior	inferior	ADJ
admet-470	112	35	pharmacokinetics	pharmacokinetic	NOUN
admet-470	112	36	.	.	PUNCT
admet-470	113	1	the	the	DET
admet-470	113	2	results	result	NOUN
admet-470	113	3	also	also	ADV
admet-470	113	4	highlight	highlight	VERB
admet-470	113	5	the	the	DET
admet-470	113	6	danger	danger	NOUN
admet-470	113	7	in	in	ADP
admet-470	113	8	deprioritizing	deprioritizing	NOUN
admet-470	113	9	compounds	compound	NOUN
admet-470	113	10	just	just	ADV
admet-470	113	11	by	by	ADP
admet-470	113	12	applying	apply	VERB
admet-470	113	13	a	a	DET
admet-470	113	14	cut	cut	NOUN
admet-470	113	15	-	-	PUNCT
admet-470	113	16	off	off	NOUN
admet-470	113	17	for	for	ADP
admet-470	113	18	,	,	PUNCT
admet-470	113	19	for	for	ADP
admet-470	113	20	example	example	NOUN
admet-470	113	21	,	,	PUNCT
admet-470	113	22	metabolic	metabolic	NOUN
admet-470	113	23	stability	stability	NOUN
admet-470	113	24	.	.	PUNCT
admet-470	114	1	here	here	ADV
admet-470	114	2	,	,	PUNCT
admet-470	114	3	three	three	NUM
admet-470	114	4	compounds	compound	NOUN
admet-470	114	5	had	have	VERB
admet-470	114	6	(	(	PUNCT
admet-470	114	7	predicted	predict	VERB
admet-470	114	8	)	)	PUNCT
admet-470	114	9	clint	clint	NOUN
admet-470	114	10	values	value	NOUN
admet-470	114	11	higher	high	ADJ
admet-470	114	12	than	than	ADP
admet-470	114	13	20	20	NUM
admet-470	114	14	µl	µl	ADP
admet-470	114	15	/	/	SYM
admet-470	114	16	min/106	min/106	NOUN
admet-470	114	17	cells	cell	NOUN
admet-470	114	18	,	,	PUNCT
admet-470	114	19	compounds	compound	VERB
admet-470	114	20	12	12	NUM
admet-470	114	21	,	,	PUNCT
admet-470	114	22	14a	14a	NOUN
admet-470	114	23	and	and	CCONJ
admet-470	114	24	19	19	NUM
admet-470	114	25	.	.	PUNCT
admet-470	115	1	for	for	ADP
admet-470	115	2	12	12	NUM
admet-470	115	3	,	,	PUNCT
admet-470	115	4	a	a	DET
admet-470	115	5	reference	reference	NOUN
admet-470	115	6	compound	compound	NOUN
admet-470	115	7	,	,	PUNCT
admet-470	115	8	threshold	threshold	NOUN
admet-470	115	9	pic50	pic50	NOUN
admet-470	115	10	was	be	AUX
admet-470	115	11	one	one	NUM
admet-470	115	12	of	of	ADP
admet-470	115	13	the	the	DET
admet-470	115	14	lowest	low	ADJ
admet-470	115	15	in	in	ADP
admet-470	115	16	the	the	DET
admet-470	115	17	whole	whole	ADJ
admet-470	115	18	set	set	NOUN
admet-470	115	19	based	base	VERB
admet-470	115	20	on	on	ADP
admet-470	115	21	a	a	DET
admet-470	115	22	predicted	predict	VERB
admet-470	115	23	blood	blood	NOUN
admet-470	115	24	clearance	clearance	NOUN
admet-470	115	25	below	below	ADP
admet-470	115	26	5	5	NUM
admet-470	115	27	ml	ml	NOUN
admet-470	115	28	/	/	SYM
admet-470	115	29	min	min	NOUN
admet-470	115	30	/	/	SYM
admet-470	115	31	kg	kg	PROPN
admet-470	115	32	,	,	PUNCT
admet-470	115	33	whereas	whereas	SCONJ
admet-470	115	34	14a	14a	NOUN
admet-470	115	35	showed	show	VERB
admet-470	115	36	an	an	DET
admet-470	115	37	intermediate	intermediate	ADJ
admet-470	115	38	threshold	threshold	NOUN
admet-470	115	39	pic50	pic50	NOUN
admet-470	115	40	(	(	PUNCT
admet-470	115	41	8.2	8.2	NUM
admet-470	115	42	)	)	PUNCT
admet-470	115	43	and	and	CCONJ
admet-470	115	44	blood	blood	NOUN
admet-470	115	45	clearance	clearance	NOUN
admet-470	115	46	just	just	ADV
admet-470	115	47	above	above	ADP
admet-470	115	48	5	5	NUM
admet-470	115	49	ml	ml	NOUN
admet-470	115	50	/	/	SYM
admet-470	115	51	min	min	NOUN
admet-470	115	52	/	/	SYM
admet-470	115	53	kg	kg	PROPN
admet-470	115	54	.	.	PUNCT
admet-470	116	1	only	only	ADV
admet-470	116	2	for	for	ADP
admet-470	116	3	compound	compound	NOUN
admet-470	116	4	19	19	NUM
admet-470	116	5	the	the	DET
admet-470	116	6	threshold	threshold	NOUN
admet-470	116	7	pic50	pic50	NOUN
admet-470	116	8	was	be	AUX
admet-470	116	9	estimated	estimate	VERB
admet-470	116	10	to	to	PART
admet-470	116	11	be	be	AUX
admet-470	116	12	on	on	ADP
admet-470	116	13	the	the	DET
admet-470	116	14	high	high	ADJ
admet-470	116	15	end	end	NOUN
admet-470	116	16	within	within	ADP
admet-470	116	17	the	the	DET
admet-470	116	18	present	present	ADJ
admet-470	116	19	set	set	NOUN
admet-470	116	20	,	,	PUNCT
admet-470	116	21	even	even	ADV
admet-470	116	22	though	though	SCONJ
admet-470	116	23	the	the	DET
admet-470	116	24	blood	blood	NOUN
admet-470	116	25	clearance	clearance	NOUN
admet-470	116	26	was	be	AUX
admet-470	116	27	again	again	ADV
admet-470	116	28	predicted	predict	VERB
admet-470	116	29	as	as	ADP
admet-470	116	30	just	just	ADV
admet-470	116	31	above	above	ADP
admet-470	116	32	5	5	NUM
admet-470	116	33	ml	ml	NOUN
admet-470	116	34	/	/	SYM
admet-470	116	35	min	min	NOUN
admet-470	116	36	/	/	SYM
admet-470	116	37	kg	kg	PROPN
admet-470	116	38	.	.	PROPN
admet-470	116	39	22	22	NUM
admet-470	116	40	,	,	PUNCT
admet-470	116	41	the	the	DET
admet-470	116	42	compound	compound	NOUN
admet-470	116	43	with	with	ADP
admet-470	116	44	the	the	DET
admet-470	116	45	highest	high	ADJ
admet-470	116	46	threshold	threshold	NOUN
admet-470	116	47	pic50	pic50	NOUN
admet-470	116	48	has	have	AUX
admet-470	116	49	almost	almost	ADV
admet-470	116	50	double	double	DET
admet-470	116	51	the	the	DET
admet-470	116	52	blood	blood	NOUN
admet-470	116	53	clearance	clearance	NOUN
admet-470	116	54	despite	despite	SCONJ
admet-470	116	55	a	a	DET
admet-470	116	56	lower	low	ADJ
admet-470	116	57	hepatocyte	hepatocyte	NOUN
admet-470	116	58	clint	clint	NOUN
admet-470	116	59	(	(	PUNCT
admet-470	116	60	~	~	PUNCT
admet-470	116	61	8	8	NUM
admet-470	116	62	µl	µl	NOUN
admet-470	116	63	/	/	SYM
admet-470	116	64	min/106	min/106	NOUN
admet-470	116	65	cells	cell	NOUN
admet-470	116	66	)	)	PUNCT
admet-470	116	67	.	.	PUNCT
admet-470	117	1	rank	rank	NOUN
admet-470	117	2	order	order	NOUN
admet-470	117	3	differences	difference	NOUN
admet-470	117	4	between	between	ADP
admet-470	117	5	in	in	ADP
admet-470	117	6	vitro	vitro	X
admet-470	117	7	(	(	PUNCT
admet-470	117	8	or	or	CCONJ
admet-470	117	9	in	in	ADP
admet-470	117	10	silico	silico	NOUN
admet-470	117	11	)	)	PUNCT
admet-470	117	12	clint	clint	NOUN
admet-470	117	13	and	and	CCONJ
admet-470	117	14	predicted	predict	VERB
admet-470	117	15	in	in	ADP
admet-470	117	16	vivo	vivo	ADJ
admet-470	117	17	clearance	clearance	NOUN
admet-470	117	18	can	can	AUX
admet-470	117	19	be	be	AUX
admet-470	117	20	explained	explain	VERB
admet-470	117	21	by	by	ADP
admet-470	117	22	the	the	DET
admet-470	117	23	different	different	ADJ
admet-470	117	24	binding	bind	VERB
admet-470	117	25	properties	property	NOUN
admet-470	117	26	:	:	PUNCT
admet-470	117	27	high	high	ADJ
admet-470	117	28	binding	bind	VERB
admet-470	117	29	in	in	ADP
admet-470	117	30	the	the	DET
admet-470	117	31	incubation	incubation	NOUN
admet-470	117	32	,	,	PUNCT
admet-470	117	33	i.e.	i.e.	X
admet-470	117	34	,	,	PUNCT
admet-470	117	35	low	low	ADJ
admet-470	117	36	fuinc	fuinc	ADJ
admet-470	117	37	values	value	NOUN
admet-470	117	38	,	,	PUNCT
admet-470	117	39	will	will	AUX
admet-470	117	40	potentiate	potentiate	VERB
admet-470	117	41	the	the	DET
admet-470	117	42	metabolic	metabolic	NOUN
admet-470	117	43	instability	instability	NOUN
admet-470	117	44	measured	measure	VERB
admet-470	117	45	in	in	ADP
admet-470	117	46	the	the	DET
admet-470	117	47	incubation	incubation	NOUN
admet-470	117	48	,	,	PUNCT
admet-470	117	49	whereas	whereas	SCONJ
admet-470	117	50	high	high	ADJ
admet-470	117	51	binding	bind	VERB
admet-470	117	52	in	in	ADP
admet-470	117	53	plasma	plasma	NOUN
admet-470	117	54	,	,	PUNCT
admet-470	117	55	i.e.	i.e.	X
admet-470	117	56	,	,	PUNCT
admet-470	117	57	low	low	ADJ
admet-470	117	58	fu	fu	NOUN
admet-470	117	59	,	,	PUNCT
admet-470	117	60	can	can	AUX
admet-470	117	61	to	to	ADP
admet-470	117	62	some	some	DET
admet-470	117	63	extent	extent	NOUN
admet-470	117	64	mitigate	mitigate	VERB
admet-470	117	65	low	low	ADJ
admet-470	117	66	metabolic	metabolic	NOUN
admet-470	117	67	stability	stability	NOUN
admet-470	117	68	seen	see	VERB
admet-470	117	69	in	in	ADP
admet-470	117	70	vitro	vitro	VERB
admet-470	117	71	.	.	PUNCT
admet-470	118	1	furthermore	furthermore	ADV
admet-470	118	2	,	,	PUNCT
admet-470	118	3	minimum	minimum	ADJ
admet-470	118	4	concentrations	concentration	NOUN
admet-470	118	5	mainly	mainly	ADV
admet-470	118	6	depend	depend	VERB
admet-470	118	7	on	on	ADP
admet-470	118	8	a	a	DET
admet-470	118	9	compound	compound	NOUN
admet-470	118	10	’s	’s	PART
admet-470	118	11	half	half	ADJ
admet-470	118	12	-	-	PUNCT
admet-470	118	13	life	life	NOUN
admet-470	118	14	,	,	PUNCT
admet-470	118	15	determined	determine	VERB
admet-470	118	16	by	by	ADP
admet-470	118	17	clearance	clearance	NOUN
admet-470	118	18	and	and	CCONJ
admet-470	118	19	volume	volume	NOUN
admet-470	118	20	of	of	ADP
admet-470	118	21	distribution	distribution	NOUN
admet-470	118	22	.	.	PUNCT
admet-470	119	1	thus	thus	ADV
admet-470	119	2	,	,	PUNCT
admet-470	119	3	volume	volume	NOUN
admet-470	119	4	of	of	ADP
admet-470	119	5	distribution	distribution	NOUN
admet-470	119	6	is	be	AUX
admet-470	119	7	another	another	DET
admet-470	119	8	important	important	ADJ
admet-470	119	9	factor	factor	NOUN
admet-470	119	10	that	that	PRON
admet-470	119	11	again	again	ADV
admet-470	119	12	may	may	AUX
admet-470	119	13	change	change	VERB
admet-470	119	14	the	the	DET
admet-470	119	15	rank	rank	NOUN
admet-470	119	16	order	order	NOUN
admet-470	119	17	.	.	PUNCT
admet-470	120	1	admet	admet	PROPN
admet-470	120	2	&	&	CCONJ
admet-470	120	3	dmpk	dmpk	PROPN
admet-470	120	4	6(1	6(1	NUM
admet-470	120	5	)	)	PUNCT
admet-470	120	6	(	(	PUNCT
admet-470	120	7	2018	2018	NUM
admet-470	120	8	)	)	PUNCT
admet-470	120	9	15	15	NUM
admet-470	120	10	-	-	SYM
admet-470	120	11	33	33	NUM
admet-470	120	12	in	in	ADP
admet-470	120	13	silico	silico	NOUN
admet-470	120	14	adme	adme	NOUN
admet-470	120	15	in	in	ADP
admet-470	120	16	drug	drug	NOUN
admet-470	120	17	design	design	NOUN
admet-470	120	18	doi	doi	NOUN
admet-470	120	19	:	:	PUNCT
admet-470	120	20	10.5599	10.5599	NUM
admet-470	120	21	/	/	SYM
admet-470	120	22	admet.6.1.470	admet.6.1.470	X
admet-470	120	23	21	21	NUM
admet-470	120	24	table	table	NOUN
admet-470	120	25	1	1	NUM
admet-470	120	26	.	.	PUNCT
admet-470	120	27	predicted	predict	VERB
admet-470	120	28	properties	property	NOUN
admet-470	120	29	for	for	ADP
admet-470	120	30	compound	compound	NOUN
admet-470	120	31	set	set	NOUN
admet-470	120	32	1	1	NUM
admet-470	121	1	[	[	X
admet-470	121	2	11	11	NUM
admet-470	121	3	]	]	PUNCT
admet-470	121	4	using	use	VERB
admet-470	121	5	astrazeneca	astrazeneca	NOUN
admet-470	121	6	in	in	ADP
admet-470	121	7	-	-	PUNCT
admet-470	121	8	house	house	NOUN
admet-470	121	9	in	in	ADP
admet-470	121	10	silico	silico	NOUN
admet-470	121	11	adme	adme	NOUN
admet-470	121	12	models	model	NOUN
admet-470	121	13	cmpd	cmpd	PROPN
admet-470	121	14	ida	ida	PROPN
admet-470	121	15	clinthh	clinthh	PROPN
admet-470	121	16	b	b	PROPN
admet-470	121	17	(	(	PUNCT
admet-470	121	18	l	l	PROPN
admet-470	121	19	/	/	SYM
admet-470	121	20	min/106	min/106	NOUN
admet-470	121	21	cells	cell	NOUN
admet-470	121	22	)	)	PUNCT
admet-470	121	23	fuinc	fuinc	PROPN
admet-470	121	24	c	c	PROPN
admet-470	121	25	%	%	NOUN
admet-470	121	26	free	free	ADJ
admet-470	121	27	fud	fud	PROPN
admet-470	121	28	%	%	NOUN
admet-470	121	29	free	free	ADJ
admet-470	121	30	papp	papp	NOUN
admet-470	121	31	e	e	X
admet-470	121	32	(	(	PUNCT
admet-470	121	33	10	10	NUM
admet-470	121	34	-	-	SYM
admet-470	121	35	6	6	NUM
admet-470	121	36	cm	cm	NOUN
admet-470	121	37	/	/	SYM
admet-470	121	38	sec	sec	PROPN
admet-470	121	39	)	)	PUNCT
admet-470	121	40	vf	vf	NOUN
admet-470	121	41	(	(	PUNCT
admet-470	121	42	l	l	NOUN
admet-470	121	43	/	/	SYM
admet-470	121	44	kg	kg	NOUN
admet-470	121	45	)	)	PUNCT
admet-470	121	46	mwg	mwg	PROPN
admet-470	121	47	(	(	PUNCT
admet-470	121	48	g	g	PROPN
admet-470	121	49	/	/	SYM
admet-470	121	50	mol	mol	NOUN
admet-470	121	51	)	)	PUNCT
admet-470	121	52	ion	ion	NOUN
admet-470	121	53	class	class	NOUN
admet-470	121	54	12	12	NUM
admet-470	121	55	20.2	20.2	NUM
admet-470	121	56	37.7	37.7	NUM
admet-470	121	57	1.1	1.1	NUM
admet-470	121	58	20	20	NUM
admet-470	121	59	2.0	2.0	NUM
admet-470	121	60	447.6	447.6	NUM
admet-470	121	61	neutral	neutral	ADJ
admet-470	121	62	13a	13a	NOUN
admet-470	121	63	15.0	15.0	NUM
admet-470	121	64	38.1	38.1	NUM
admet-470	121	65	2.5	2.5	NUM
admet-470	121	66	5	5	NUM
admet-470	121	67	2.1	2.1	NUM
admet-470	121	68	433.6	433.6	NUM
admet-470	121	69	neutral	neutral	ADJ
admet-470	121	70	13b	13b	NOUN
admet-470	121	71	6.5	6.5	NUM
admet-470	121	72	25.4	25.4	NUM
admet-470	121	73	3.4	3.4	NUM
admet-470	121	74	9	9	NUM
admet-470	121	75	2.0	2.0	NUM
admet-470	121	76	433.6	433.6	NUM
admet-470	121	77	neutral	neutral	ADJ
admet-470	121	78	14a	14a	NOUN
admet-470	121	79	27.3	27.3	NUM
admet-470	121	80	80.2	80.2	NUM
admet-470	121	81	2.4	2.4	NUM
admet-470	121	82	26	26	NUM
admet-470	121	83	1.7	1.7	NUM
admet-470	121	84	447.5	447.5	NUM
admet-470	121	85	neutral	neutral	ADJ
admet-470	121	86	14b	14b	NUM
admet-470	121	87	7.5	7.5	NUM
admet-470	121	88	72.4	72.4	NUM
admet-470	121	89	15.3	15.3	NUM
admet-470	121	90	5	5	NUM
admet-470	121	91	2.0	2.0	NUM
admet-470	121	92	446.5	446.5	NUM
admet-470	121	93	base	base	NOUN
admet-470	121	94	14c	14c	NUM
admet-470	121	95	9.5	9.5	NUM
admet-470	121	96	73.1	73.1	NUM
admet-470	121	97	10.5	10.5	NUM
admet-470	121	98	36	36	NUM
admet-470	121	99	1.3	1.3	NUM
admet-470	121	100	431.5	431.5	NUM
admet-470	121	101	neutral	neutral	ADJ
admet-470	121	102	14d	14d	NOUN
admet-470	121	103	10.3	10.3	NUM
admet-470	121	104	83.5	83.5	NUM
admet-470	121	105	9.4	9.4	NUM
admet-470	121	106	10	10	NUM
admet-470	121	107	0.9	0.9	NUM
admet-470	121	108	444.5	444.5	NUM
admet-470	121	109	neutral	neutral	ADJ
admet-470	121	110	14e	14e	NOUN
admet-470	121	111	6.8	6.8	NUM
admet-470	121	112	74.9	74.9	NUM
admet-470	121	113	4.3	4.3	NUM
admet-470	121	114	27	27	NUM
admet-470	121	115	1.5	1.5	NUM
admet-470	121	116	447.5	447.5	NUM
admet-470	121	117	neutral	neutral	ADJ
admet-470	121	118	15a	15a	NOUN
admet-470	121	119	10.3	10.3	NUM
admet-470	121	120	70.6	70.6	NUM
admet-470	121	121	7.5	7.5	NUM
admet-470	121	122	2	2	NUM
admet-470	121	123	1.2	1.2	NUM
admet-470	121	124	433.5	433.5	NUM
admet-470	121	125	neutral	neutral	ADJ
admet-470	121	126	15b	15b	NOUN
admet-470	121	127	3.7	3.7	NUM
admet-470	121	128	56.9	56.9	NUM
admet-470	121	129	10.2	10.2	NUM
admet-470	121	130	7	7	NUM
admet-470	121	131	1.4	1.4	NUM
admet-470	121	132	433.5	433.5	NUM
admet-470	121	133	neutral	neutral	ADJ
admet-470	121	134	15c	15c	NOUN
admet-470	121	135	6.7	6.7	NUM
admet-470	121	136	55.7	55.7	NUM
admet-470	121	137	5.3	5.3	NUM
admet-470	121	138	12	12	NUM
admet-470	121	139	1.5	1.5	NUM
admet-470	121	140	432.5	432.5	NUM
admet-470	121	141	neutral	neutral	ADJ
admet-470	121	142	15d	15d	NUM
admet-470	121	143	3.6	3.6	NUM
admet-470	121	144	47.4	47.4	NUM
admet-470	121	145	10.7	10.7	NUM
admet-470	121	146	7	7	NUM
admet-470	121	147	1.4	1.4	NUM
admet-470	121	148	433.5	433.5	NUM
admet-470	121	149	neutral	neutral	ADJ
admet-470	121	150	15e	15e	NOUN
admet-470	121	151	6.3	6.3	NUM
admet-470	121	152	55.9	55.9	NUM
admet-470	121	153	4.2	4.2	NUM
admet-470	121	154	11	11	NUM
admet-470	121	155	1.4	1.4	NUM
admet-470	121	156	447.5	447.5	NUM
admet-470	121	157	neutral	neutral	ADJ
admet-470	121	158	15f	15f	NOUN
admet-470	121	159	6.1	6.1	NUM
admet-470	121	160	47.6	47.6	NUM
admet-470	121	161	5.0	5.0	NUM
admet-470	121	162	7	7	NUM
admet-470	121	163	1.4	1.4	NUM
admet-470	121	164	431.5	431.5	NUM
admet-470	121	165	neutral	neutral	ADJ
admet-470	121	166	19	19	NUM
admet-470	121	167	32.3	32.3	NUM
admet-470	121	168	70.9	70.9	NUM
admet-470	121	169	1.8	1.8	NUM
admet-470	121	170	10	10	NUM
admet-470	121	171	0.8	0.8	NUM
admet-470	121	172	416.4	416.4	NUM
admet-470	121	173	neutral	neutral	ADJ
admet-470	121	174	20	20	NUM
admet-470	121	175	8.1	8.1	NUM
admet-470	121	176	76.1	76.1	NUM
admet-470	121	177	4.3	4.3	NUM
admet-470	121	178	12	12	NUM
admet-470	121	179	1.0	1.0	NUM
admet-470	121	180	458.5	458.5	NUM
admet-470	121	181	neutral	neutral	ADJ
admet-470	121	182	21	21	NUM
admet-470	121	183	12.9	12.9	NUM
admet-470	121	184	76.0	76.0	NUM
admet-470	121	185	2.5	2.5	NUM
admet-470	121	186	13	13	NUM
admet-470	121	187	1.2	1.2	NUM
admet-470	121	188	415.5	415.5	NUM
admet-470	121	189	neutral	neutral	ADJ
admet-470	121	190	22	22	NUM
admet-470	121	191	7.9	7.9	NUM
admet-470	121	192	39.2	39.2	NUM
admet-470	121	193	10.3	10.3	NUM
admet-470	121	194	6	6	NUM
admet-470	121	195	0.9	0.9	NUM
admet-470	121	196	386.4	386.4	NUM
admet-470	121	197	neutral	neutral	ADJ
admet-470	121	198	29	29	NUM
admet-470	121	199	4.7	4.7	NUM
admet-470	121	200	49.8	49.8	NUM
admet-470	121	201	8.0	8.0	NUM
admet-470	121	202	9	9	NUM
admet-470	121	203	1.5	1.5	NUM
admet-470	121	204	447.5	447.5	NUM
admet-470	121	205	neutral	neutral	ADJ
admet-470	121	206	30	30	NUM
admet-470	121	207	5.8	5.8	NUM
admet-470	121	208	47.5	47.5	NUM
admet-470	121	209	6.7	6.7	NUM
admet-470	121	210	9	9	NUM
admet-470	121	211	1.6	1.6	NUM
admet-470	121	212	447.5	447.5	NUM
admet-470	121	213	neutral	neutral	ADJ
admet-470	121	214	31	31	NUM
admet-470	121	215	4.1	4.1	NUM
admet-470	121	216	47.0	47.0	NUM
admet-470	121	217	9.6	9.6	NUM
admet-470	121	218	10	10	NUM
admet-470	121	219	1.5	1.5	NUM
admet-470	121	220	447.5	447.5	NUM
admet-470	121	221	neutral	neutral	ADJ
admet-470	121	222	32	32	NUM
admet-470	121	223	5.4	5.4	NUM
admet-470	121	224	52.2	52.2	NUM
admet-470	121	225	11.5	11.5	NUM
admet-470	121	226	9	9	NUM
admet-470	121	227	1.5	1.5	NUM
admet-470	121	228	445.5	445.5	NUM
admet-470	121	229	neutral	neutral	ADJ
admet-470	121	230	37	37	NUM
admet-470	121	231	2.6	2.6	NUM
admet-470	121	232	40.6	40.6	NUM
admet-470	121	233	8.8	8.8	NUM
admet-470	121	234	8	8	NUM
admet-470	121	235	1.3	1.3	NUM
admet-470	121	236	469.5	469.5	NUM
admet-470	121	237	neutral	neutral	ADJ
admet-470	121	238	41	41	NUM
admet-470	121	239	3.7	3.7	NUM
admet-470	121	240	56.9	56.9	NUM
admet-470	121	241	10.2	10.2	NUM
admet-470	121	242	7	7	NUM
admet-470	121	243	1.4	1.4	NUM
admet-470	121	244	433.5	433.5	NUM
admet-470	121	245	neutral	neutral	ADJ
admet-470	121	246	42	42	NUM
admet-470	121	247	4.6	4.6	NUM
admet-470	121	248	46.6	46.6	NUM
admet-470	121	249	7.7	7.7	NUM
admet-470	121	250	8	8	NUM
admet-470	121	251	1.7	1.7	NUM
admet-470	121	252	461.6	461.6	NUM
admet-470	121	253	neutral	neutral	ADJ
admet-470	121	254	47	47	NUM
admet-470	121	255	2.3	2.3	NUM
admet-470	121	256	67.1	67.1	NUM
admet-470	121	257	24.2	24.2	NUM
admet-470	121	258	7	7	NUM
admet-470	121	259	1.3	1.3	NUM
admet-470	121	260	433.5	433.5	NUM
admet-470	121	261	neutral	neutral	ADJ
admet-470	121	262	49	49	NUM
admet-470	121	263	4.0	4.0	NUM
admet-470	121	264	49.0	49.0	NUM
admet-470	121	265	16.9	16.9	NUM
admet-470	121	266	8	8	NUM
admet-470	121	267	1.4	1.4	NUM
admet-470	121	268	421.5	421.5	NUM
admet-470	121	269	neutral	neutral	PROPN
admet-470	121	270	a	a	DET
admet-470	121	271	cmpd	cmpd	PROPN
admet-470	121	272	i	i	PROPN
admet-470	121	273	d	d	PROPN
admet-470	121	274	:	:	PUNCT
admet-470	121	275	compound	compound	NOUN
admet-470	121	276	identification	identification	NOUN
admet-470	121	277	as	as	SCONJ
admet-470	121	278	originally	originally	ADV
admet-470	121	279	defined	define	VERB
admet-470	121	280	[	[	PUNCT
admet-470	121	281	11	11	NUM
admet-470	121	282	]	]	X
admet-470	121	283	;	;	PUNCT
admet-470	121	284	b	b	X
admet-470	121	285	clinthh	clinthh	ADJ
admet-470	121	286	:	:	PUNCT
admet-470	121	287	intrinsic	intrinsic	ADJ
admet-470	121	288	clearance	clearance	NOUN
admet-470	121	289	in	in	ADP
admet-470	121	290	human	human	ADJ
admet-470	121	291	hepatocytes	hepatocyte	NOUN
admet-470	121	292	;	;	PUNCT
admet-470	121	293	c	c	PROPN
admet-470	121	294	fuinc	fuinc	PROPN
admet-470	121	295	:	:	PUNCT
admet-470	121	296	fraction	fraction	NOUN
admet-470	121	297	unbound	unbound	NOUN
admet-470	121	298	in	in	ADP
admet-470	121	299	rat	rat	NOUN
admet-470	121	300	hepatocyte	hepatocyte	NOUN
admet-470	121	301	incubation	incubation	NOUN
admet-470	121	302	;	;	PUNCT
admet-470	121	303	d	d	X
admet-470	121	304	fu	fu	NOUN
admet-470	121	305	:	:	PUNCT
admet-470	121	306	fraction	fraction	NOUN
admet-470	121	307	unbound	unbound	NOUN
admet-470	121	308	in	in	ADP
admet-470	121	309	human	human	ADJ
admet-470	121	310	blood	blood	NOUN
admet-470	121	311	plasma	plasma	NOUN
admet-470	121	312	;	;	PUNCT
admet-470	121	313	e	e	X
admet-470	121	314	papp	papp	NOUN
admet-470	121	315	:	:	PUNCT
admet-470	121	316	apparent	apparent	ADJ
admet-470	121	317	permeability	permeability	NOUN
admet-470	121	318	in	in	ADP
admet-470	121	319	caco2	caco2	NOUN
admet-470	121	320	cells	cell	NOUN
admet-470	121	321	with	with	ADP
admet-470	121	322	transport	transport	NOUN
admet-470	121	323	inhibition	inhibition	NOUN
admet-470	121	324	;	;	PUNCT
admet-470	121	325	f	f	PROPN
admet-470	121	326	v	v	NOUN
admet-470	121	327	:	:	PUNCT
admet-470	121	328	human	human	ADJ
admet-470	121	329	volume	volume	NOUN
admet-470	121	330	of	of	ADP
admet-470	121	331	distribution	distribution	NOUN
admet-470	121	332	at	at	ADP
admet-470	121	333	steady	steady	ADJ
admet-470	121	334	state	state	NOUN
admet-470	121	335	;	;	PUNCT
admet-470	121	336	g	g	PROPN
admet-470	121	337	mw	mw	PROPN
admet-470	121	338	:	:	PUNCT
admet-470	121	339	molecular	molecular	ADJ
admet-470	121	340	weight	weight	NOUN
admet-470	121	341	susanne	susanne	PROPN
admet-470	121	342	winiwarter	winiwarter	PROPN
admet-470	121	343	et	et	PROPN
admet-470	121	344	al	al	PROPN
admet-470	121	345	.	.	PROPN
admet-470	121	346	admet	admet	PROPN
admet-470	121	347	&	&	CCONJ
admet-470	121	348	dmpk	dmpk	PROPN
admet-470	121	349	6(1	6(1	NUM
admet-470	121	350	)	)	PUNCT
admet-470	121	351	(	(	PUNCT
admet-470	121	352	2018	2018	NUM
admet-470	121	353	)	)	PUNCT
admet-470	121	354	15	15	NUM
admet-470	121	355	-	-	SYM
admet-470	121	356	33	33	NUM
admet-470	121	357	22	22	NUM
admet-470	121	358	table	table	NOUN
admet-470	121	359	2	2	NUM
admet-470	121	360	.	.	NUM
admet-470	121	361	predicted	predict	VERB
admet-470	121	362	pk	pk	NOUN
admet-470	121	363	properties	property	NOUN
admet-470	121	364	for	for	ADP
admet-470	121	365	compound	compound	NOUN
admet-470	121	366	set	set	NOUN
admet-470	121	367	1	1	NUM
admet-470	122	1	[	[	X
admet-470	122	2	11	11	NUM
admet-470	122	3	]	]	PUNCT
admet-470	122	4	based	base	VERB
admet-470	122	5	on	on	ADP
admet-470	122	6	in	in	ADP
admet-470	122	7	silico	silico	NOUN
admet-470	122	8	adme	adme	NOUN
admet-470	122	9	model	model	NOUN
admet-470	122	10	predictions	prediction	NOUN
admet-470	122	11	,	,	PUNCT
admet-470	123	1	plasma	plasma	NOUN
admet-470	123	2	concentrations	concentration	NOUN
admet-470	123	3	calculated	calculate	VERB
admet-470	123	4	for	for	ADP
admet-470	123	5	a	a	DET
admet-470	123	6	once	once	ADV
admet-470	123	7	daily	daily	ADJ
admet-470	123	8	dose	dose	NOUN
admet-470	123	9	of	of	ADP
admet-470	123	10	100	100	NUM
admet-470	123	11	mg	mg	PROPN
admet-470	123	12	(	(	PUNCT
admet-470	123	13	1.4	1.4	NUM
admet-470	123	14	mg	mg	PROPN
admet-470	123	15	/	/	SYM
admet-470	123	16	kg	kg	PROPN
admet-470	123	17	)	)	PUNCT
admet-470	123	18	,	,	PUNCT
admet-470	123	19	sorted	sort	VERB
admet-470	123	20	by	by	ADP
admet-470	123	21	threshold	threshold	NOUN
admet-470	123	22	pic50	pic50	PROPN
admet-470	123	23	cmpd	cmpd	PROPN
admet-470	123	24	ida	ida	PROPN
admet-470	123	25	cl	cl	PROPN
admet-470	123	26	bloodb	bloodb	NOUN
admet-470	123	27	(	(	PUNCT
admet-470	123	28	ml	ml	NOUN
admet-470	123	29	/	/	SYM
admet-470	123	30	min	min	NOUN
admet-470	123	31	/	/	SYM
admet-470	123	32	kg	kg	NOUN
admet-470	123	33	)	)	PUNCT
admet-470	123	34	cave	cave	NOUN
admet-470	123	35	c	c	PROPN
admet-470	123	36	(	(	PUNCT
admet-470	123	37	m	m	PROPN
admet-470	123	38	)	)	PUNCT
admet-470	123	39	cmin	cmin	PROPN
admet-470	123	40	d	d	PROPN
admet-470	123	41	(	(	PUNCT
admet-470	123	42	m	m	PROPN
admet-470	123	43	)	)	PUNCT
admet-470	123	44	cmax	cmax	NOUN
admet-470	123	45	e	e	X
admet-470	123	46	(	(	PUNCT
admet-470	123	47	m	m	PROPN
admet-470	123	48	)	)	PUNCT
admet-470	123	49	threshold	threshold	NOUN
admet-470	123	50	pic50	pic50	NOUN
admet-470	123	51	from	from	ADP
admet-470	123	52	cmin	cmin	PROPN
admet-470	123	53	f	f	PROPN
admet-470	123	54	cmax	cmax	X
admet-470	123	55	/	/	SYM
admet-470	123	56	cmin	cmin	PROPN
admet-470	123	57	g	g	PROPN
admet-470	123	58	14e	14e	NOUN
admet-470	123	59	2.88	2.88	NUM
admet-470	123	60	0.66	0.66	NUM
admet-470	123	61	0.12904	0.12904	NUM
admet-470	123	62	1.90	1.90	NUM
admet-470	123	63	7.4	7.4	NUM
admet-470	123	64	14.7	14.7	NUM
admet-470	123	65	12	12	NUM
admet-470	123	66	4.17	4.17	NUM
admet-470	123	67	0.42	0.42	NUM
admet-470	123	68	0.06645	0.06645	NUM
admet-470	123	69	1.32	1.32	NUM
admet-470	123	70	7.7	7.7	NUM
admet-470	123	71	19.9	19.9	NUM
admet-470	123	72	15e	15e	NOUN
admet-470	123	73	3.41	3.41	NUM
admet-470	123	74	0.54	0.54	NUM
admet-470	123	75	0.06363	0.06363	NUM
admet-470	123	76	1.90	1.90	NUM
admet-470	123	77	7.7	7.7	NUM
admet-470	123	78	29.8	29.8	NUM
admet-470	123	79	21	21	NUM
admet-470	123	80	3.13	3.13	NUM
admet-470	123	81	0.64	0.64	NUM
admet-470	123	82	0.06105	0.06105	NUM
admet-470	123	83	2.44	2.44	NUM
admet-470	123	84	7.7	7.7	NUM
admet-470	123	85	39.9	39.9	NUM
admet-470	123	86	15c	15c	NOUN
admet-470	123	87	4.33	4.33	NUM
admet-470	123	88	0.42	0.42	NUM
admet-470	123	89	0.02902	0.02902	NUM
admet-470	123	90	1.73	1.73	NUM
admet-470	123	91	8.0	8.0	NUM
admet-470	123	92	59.5	59.5	NUM
admet-470	123	93	20	20	NUM
admet-470	123	94	3.30	3.30	NUM
admet-470	123	95	0.55	0.55	NUM
admet-470	123	96	0.02517	0.02517	NUM
admet-470	123	97	2.56	2.56	NUM
admet-470	123	98	8.1	8.1	NUM
admet-470	123	99	101.6	101.6	NUM
admet-470	123	100	42	42	NUM
admet-470	123	101	4.92	4.92	NUM
admet-470	123	102	0.33	0.33	NUM
admet-470	123	103	0.02259	0.02259	NUM
admet-470	123	104	1.38	1.38	NUM
admet-470	123	105	8.1	8.1	NUM
admet-470	123	106	61.0	61.0	NUM
admet-470	123	107	13b	13b	NOUN
admet-470	123	108	5.45	5.45	NUM
admet-470	123	109	0.31	0.31	NUM
admet-470	123	110	0.02254	0.02254	NUM
admet-470	123	111	1.25	1.25	NUM
admet-470	123	112	8.1	8.1	NUM
admet-470	123	113	55.4	55.4	NUM
admet-470	123	114	37	37	NUM
admet-470	123	115	3.96	3.96	NUM
admet-470	123	116	0.43	0.43	NUM
admet-470	123	117	0.02136	0.02136	NUM
admet-470	123	118	1.96	1.96	NUM
admet-470	123	119	8.1	8.1	NUM
admet-470	123	120	91.5	91.5	NUM
admet-470	123	121	15b	15b	NOUN
admet-470	123	122	4.47	4.47	NUM
admet-470	123	123	0.40	0.40	NUM
admet-470	123	124	0.01900	0.01900	NUM
admet-470	123	125	1.84	1.84	NUM
admet-470	123	126	8.2	8.2	NUM
admet-470	123	127	96.8	96.8	NUM
admet-470	123	128	41	41	NUM
admet-470	123	129	4.47	4.47	NUM
admet-470	123	130	0.40	0.40	NUM
admet-470	123	131	0.01900	0.01900	NUM
admet-470	123	132	1.84	1.84	NUM
admet-470	123	133	8.2	8.2	NUM
admet-470	123	134	96.8	96.8	NUM
admet-470	123	135	15f	15f	NOUN
admet-470	123	136	4.37	4.37	NUM
admet-470	123	137	0.41	0.41	NUM
admet-470	123	138	0.01864	0.01864	NUM
admet-470	123	139	1.93	1.93	NUM
admet-470	123	140	8.2	8.2	NUM
admet-470	123	141	103.4	103.4	NUM
admet-470	123	142	14a	14a	NOUN
admet-470	123	143	5.22	5.22	NUM
admet-470	123	144	0.31	0.31	NUM
admet-470	123	145	0.01757	0.01757	NUM
admet-470	123	146	1.39	1.39	NUM
admet-470	123	147	8.2	8.2	NUM
admet-470	123	148	79.2	79.2	NUM
admet-470	123	149	13a	13a	NOUN
admet-470	123	150	6.03	6.03	NUM
admet-470	123	151	0.26	0.26	NUM
admet-470	123	152	0.01675	0.01675	NUM
admet-470	123	153	1.13	1.13	NUM
admet-470	123	154	8.3	8.3	NUM
admet-470	123	155	67.7	67.7	NUM
admet-470	123	156	29	29	NUM
admet-470	123	157	4.88	4.88	NUM
admet-470	123	158	0.34	0.34	NUM
admet-470	123	159	0.01431	0.01431	NUM
admet-470	123	160	1.64	1.64	NUM
admet-470	123	161	8.3	8.3	NUM
admet-470	123	162	114.7	114.7	NUM
admet-470	123	163	30	30	NUM
admet-470	123	164	5.27	5.27	NUM
admet-470	123	165	0.31	0.31	NUM
admet-470	123	166	0.01154	0.01154	NUM
admet-470	123	167	1.53	1.53	NUM
admet-470	123	168	8.4	8.4	NUM
admet-470	123	169	132.3	132.3	NUM
admet-470	123	170	31	31	NUM
admet-470	123	171	5.36	5.36	NUM
admet-470	123	172	0.30	0.30	NUM
admet-470	123	173	0.00998	0.00998	NUM
admet-470	123	174	1.54	1.54	NUM
admet-470	123	175	8.5	8.5	NUM
admet-470	123	176	154.0	154.0	NUM
admet-470	123	177	15d	15d	NUM
admet-470	123	178	5.26	5.26	NUM
admet-470	123	179	0.32	0.32	NUM
admet-470	123	180	0.00709	0.00709	NUM
admet-470	123	181	1.78	1.78	NUM
admet-470	123	182	8.6	8.6	NUM
admet-470	123	183	250.9	250.9	NUM
admet-470	123	184	47	47	NUM
admet-470	123	185	5.34	5.34	NUM
admet-470	123	186	0.31	0.31	NUM
admet-470	123	187	0.00599	0.00599	NUM
admet-470	123	188	1.80	1.80	NUM
admet-470	123	189	8.7	8.7	NUM
admet-470	123	190	300.1	300.1	NUM
admet-470	123	191	14b	14b	NUM
admet-470	123	192	8.10	8.10	NUM
admet-470	123	193	0.16	0.16	NUM
admet-470	123	194	0.00259	0.00259	NUM
admet-470	123	195	0.97	0.97	NUM
admet-470	123	196	9.1	9.1	NUM
admet-470	123	197	374.3	374.3	NUM
admet-470	123	198	32	32	NUM
admet-470	123	199	6.83	6.83	NUM
admet-470	123	200	0.21	0.21	NUM
admet-470	123	201	0.00171	0.00171	NUM
admet-470	123	202	1.45	1.45	NUM
admet-470	123	203	9.2	9.2	NUM
admet-470	123	204	846.0	846.0	NUM
admet-470	123	205	15a	15a	NOUN
admet-470	123	206	6.41	6.41	NUM
admet-470	123	207	0.24	0.24	NUM
admet-470	123	208	0.00074	0.00074	NUM
admet-470	124	1	1.91	1.91	NUM
admet-470	124	2	9.6	9.6	NUM
admet-470	124	3	2573.8	2573.8	NUM
admet-470	124	4	49	49	NUM
admet-470	124	5	7.51	7.51	NUM
admet-470	124	6	0.20	0.20	NUM
admet-470	124	7	0.00060	0.00060	NUM
admet-470	124	8	1.53	1.53	NUM
admet-470	124	9	9.7	9.7	NUM
admet-470	124	10	2537.8	2537.8	NUM
admet-470	124	11	14c	14c	NOUN
admet-470	124	12	7.44	7.44	NUM
admet-470	124	13	0.19	0.19	NUM
admet-470	124	14	0.00046	0.00046	NUM
admet-470	124	15	1.58	1.58	NUM
admet-470	124	16	9.8	9.8	NUM
admet-470	124	17	3398.1	3398.1	NUM
admet-470	124	18	19	19	NUM
admet-470	124	19	5.18	5.18	NUM
admet-470	124	20	0.34	0.34	NUM
admet-470	124	21	0.00045	0.00045	NUM
admet-470	124	22	3.01	3.01	NUM
admet-470	124	23	9.8	9.8	NUM
admet-470	124	24	6751.1	6751.1	NUM
admet-470	124	25	14d	14d	NOUN
admet-470	124	26	6.65	6.65	NUM
admet-470	124	27	0.22	0.22	NUM
admet-470	124	28	0.00004	0.00004	NUM
admet-470	124	29	2.46	2.46	NUM
admet-470	124	30	10.9	10.9	NUM
admet-470	125	1	58276.0	58276.0	NUM
admet-470	125	2	22	22	NUM
admet-470	125	3	9.46	9.46	NUM
admet-470	125	4	0.14	0.14	NUM
admet-470	125	5	0.00000	0.00000	NUM
admet-470	125	6	2.20	2.20	NUM
admet-470	125	7	12.8	12.8	NUM
admet-470	125	8	4832468.9	4832468.9	NUM
admet-470	125	9	a	a	DET
admet-470	125	10	cmpd	cmpd	PROPN
admet-470	125	11	i	i	PROPN
admet-470	125	12	d	d	PROPN
admet-470	125	13	:	:	PUNCT
admet-470	125	14	compound	compound	NOUN
admet-470	125	15	identification	identification	NOUN
admet-470	125	16	as	as	SCONJ
admet-470	125	17	defined	define	VERB
admet-470	125	18	in	in	ADP
admet-470	125	19	ref	ref	NOUN
admet-470	125	20	[	[	X
admet-470	125	21	11	11	NUM
admet-470	125	22	]	]	PUNCT
admet-470	125	23	;	;	PUNCT
admet-470	125	24	b	b	X
admet-470	125	25	cl	cl	NOUN
admet-470	125	26	blood	blood	NOUN
admet-470	125	27	:	:	PUNCT
admet-470	125	28	predicted	predict	VERB
admet-470	125	29	human	human	ADJ
admet-470	125	30	blood	blood	NOUN
admet-470	125	31	clearance	clearance	NOUN
admet-470	125	32	;	;	PUNCT
admet-470	125	33	c	c	NOUN
admet-470	125	34	cave	cave	NOUN
admet-470	125	35	:	:	PUNCT
admet-470	125	36	predicted	predict	VERB
admet-470	125	37	total	total	ADJ
admet-470	125	38	average	average	ADJ
admet-470	125	39	plasma	plasma	NOUN
admet-470	125	40	concentration	concentration	NOUN
admet-470	125	41	at	at	ADP
admet-470	125	42	steady	steady	ADJ
admet-470	125	43	state	state	NOUN
admet-470	125	44	;	;	PUNCT
admet-470	125	45	d	d	X
admet-470	125	46	cmin	cmin	PROPN
admet-470	125	47	:	:	PUNCT
admet-470	125	48	predicted	predict	VERB
admet-470	125	49	total	total	ADJ
admet-470	125	50	minimum	minimum	ADJ
admet-470	125	51	plasma	plasma	NOUN
admet-470	125	52	concentration	concentration	NOUN
admet-470	125	53	at	at	ADP
admet-470	125	54	steady	steady	ADJ
admet-470	125	55	state	state	NOUN
admet-470	125	56	;	;	PUNCT
admet-470	125	57	e	e	X
admet-470	125	58	cmax	cmax	NOUN
admet-470	125	59	:	:	PUNCT
admet-470	125	60	predicted	predict	VERB
admet-470	125	61	total	total	ADJ
admet-470	125	62	maximum	maximum	ADJ
admet-470	125	63	plasma	plasma	NOUN
admet-470	125	64	concentration	concentration	NOUN
admet-470	125	65	at	at	ADP
admet-470	125	66	steady	steady	ADJ
admet-470	125	67	state	state	NOUN
admet-470	125	68	;	;	PUNCT
admet-470	125	69	f	f	X
admet-470	125	70	threshold	threshold	NOUN
admet-470	125	71	pic50	pic50	NOUN
admet-470	125	72	from	from	ADP
admet-470	125	73	cmin	cmin	NOUN
admet-470	125	74	:	:	PUNCT
admet-470	125	75	minimum	minimum	NOUN
admet-470	125	76	required	require	VERB
admet-470	125	77	pic50	pic50	NOUN
admet-470	125	78	estimated	estimate	VERB
admet-470	125	79	from	from	ADP
admet-470	125	80	cmin/3	cmin/3	NOUN
admet-470	125	81	for	for	ADP
admet-470	125	82	a	a	DET
admet-470	125	83	3fold	3fold	NUM
admet-470	125	84	coverage	coverage	NOUN
admet-470	125	85	over	over	ADP
admet-470	125	86	24	24	NUM
admet-470	125	87	hours	hour	NOUN
admet-470	125	88	;	;	PUNCT
admet-470	125	89	g	g	NOUN
admet-470	125	90	cmax	cmax	NOUN
admet-470	125	91	/	/	SYM
admet-470	125	92	cmin	cmin	NOUN
admet-470	125	93	:	:	PUNCT
admet-470	125	94	predicted	predict	VERB
admet-470	125	95	ratio	ratio	NOUN
admet-470	125	96	between	between	ADP
admet-470	125	97	maximum	maximum	ADJ
admet-470	125	98	and	and	CCONJ
admet-470	125	99	minimum	minimum	ADJ
admet-470	125	100	concentration	concentration	NOUN
admet-470	125	101	at	at	ADP
admet-470	125	102	steady	steady	ADJ
admet-470	125	103	state	state	NOUN
admet-470	125	104	admet	admet	NOUN
admet-470	125	105	&	&	CCONJ
admet-470	125	106	dmpk	dmpk	PROPN
admet-470	125	107	6(1	6(1	NUM
admet-470	125	108	)	)	PUNCT
admet-470	125	109	(	(	PUNCT
admet-470	125	110	2018	2018	NUM
admet-470	125	111	)	)	PUNCT
admet-470	125	112	15	15	NUM
admet-470	125	113	-	-	SYM
admet-470	125	114	33	33	NUM
admet-470	125	115	in	in	ADP
admet-470	125	116	silico	silico	NOUN
admet-470	125	117	adme	adme	NOUN
admet-470	125	118	in	in	ADP
admet-470	125	119	drug	drug	NOUN
admet-470	125	120	design	design	NOUN
admet-470	125	121	doi	doi	NOUN
admet-470	125	122	:	:	PUNCT
admet-470	125	123	10.5599	10.5599	NUM
admet-470	125	124	/	/	SYM
admet-470	125	125	admet.6.1.470	admet.6.1.470	NOUN
admet-470	125	126	23	23	NUM
admet-470	125	127	calculation	calculation	NOUN
admet-470	125	128	of	of	ADP
admet-470	125	129	threshold	threshold	NOUN
admet-470	125	130	potency	potency	NOUN
admet-470	125	131	for	for	ADP
admet-470	125	132	a	a	DET
admet-470	125	133	set	set	NOUN
admet-470	125	134	of	of	ADP
admet-470	125	135	known	know	VERB
admet-470	125	136	drugs	drug	NOUN
admet-470	125	137	as	as	ADP
admet-470	125	138	second	second	ADJ
admet-470	125	139	test	test	NOUN
admet-470	125	140	,	,	PUNCT
admet-470	125	141	we	we	PRON
admet-470	125	142	investigated	investigate	VERB
admet-470	125	143	the	the	DET
admet-470	125	144	approach	approach	NOUN
admet-470	125	145	for	for	ADP
admet-470	125	146	a	a	DET
admet-470	125	147	set	set	NOUN
admet-470	125	148	of	of	ADP
admet-470	125	149	marketed	market	VERB
admet-470	125	150	drugs	drug	NOUN
admet-470	125	151	where	where	SCONJ
admet-470	125	152	information	information	NOUN
admet-470	125	153	on	on	ADP
admet-470	125	154	dosing	dosing	NOUN
admet-470	125	155	and	and	CCONJ
admet-470	125	156	human	human	ADJ
admet-470	125	157	pharmacokinetic	pharmacokinetic	ADJ
admet-470	125	158	data	datum	NOUN
admet-470	125	159	had	have	AUX
admet-470	125	160	been	be	AUX
admet-470	125	161	collated	collate	VERB
admet-470	125	162	by	by	ADP
admet-470	125	163	mcginnity	mcginnity	NOUN
admet-470	125	164	et	et	PROPN
admet-470	125	165	al	al	PROPN
admet-470	125	166	.	.	PUNCT
admet-470	126	1	[	[	X
admet-470	126	2	9	9	NUM
admet-470	126	3	]	]	PUNCT
admet-470	126	4	.	.	PUNCT
admet-470	127	1	this	this	DET
admet-470	127	2	dataset	dataset	NOUN
admet-470	127	3	was	be	AUX
admet-470	127	4	previously	previously	ADV
admet-470	127	5	used	use	VERB
admet-470	127	6	to	to	PART
admet-470	127	7	evaluate	evaluate	VERB
admet-470	127	8	the	the	DET
admet-470	127	9	validity	validity	NOUN
admet-470	127	10	of	of	ADP
admet-470	127	11	early	early	ADJ
admet-470	127	12	dose	dose	NOUN
admet-470	127	13	to	to	ADP
admet-470	127	14	man	man	NOUN
admet-470	127	15	predictions	prediction	NOUN
admet-470	127	16	[	[	X
admet-470	127	17	9	9	NUM
admet-470	127	18	,	,	PUNCT
admet-470	127	19	10	10	NUM
admet-470	127	20	]	]	PUNCT
admet-470	127	21	.	.	PUNCT
admet-470	128	1	table	table	NOUN
admet-470	128	2	3	3	NUM
admet-470	128	3	shows	show	NOUN
admet-470	128	4	in	in	ADP
admet-470	128	5	silico	silico	NOUN
admet-470	128	6	adme	adme	NOUN
admet-470	128	7	parameters	parameter	NOUN
admet-470	128	8	for	for	ADP
admet-470	128	9	the	the	DET
admet-470	128	10	21	21	NUM
admet-470	128	11	drugs	drug	NOUN
admet-470	128	12	predicted	predict	VERB
admet-470	128	13	with	with	ADP
admet-470	128	14	the	the	DET
admet-470	128	15	present	present	ADJ
admet-470	128	16	models	model	NOUN
admet-470	128	17	at	at	ADP
admet-470	128	18	astrazeneca	astrazeneca	PROPN
admet-470	128	19	.	.	PUNCT
admet-470	128	20	table	table	PROPN
admet-470	129	1	3	3	NUM
admet-470	129	2	.	.	PUNCT
admet-470	129	3	predicted	predict	VERB
admet-470	129	4	properties	property	NOUN
admet-470	129	5	for	for	ADP
admet-470	129	6	21	21	NUM
admet-470	129	7	known	know	VERB
admet-470	129	8	drugs	drug	NOUN
admet-470	129	9	[	[	X
admet-470	129	10	9	9	NUM
admet-470	129	11	]	]	PUNCT
admet-470	129	12	using	use	VERB
admet-470	129	13	astrazeneca	astrazeneca	NOUN
admet-470	129	14	in	in	ADP
admet-470	129	15	-	-	PUNCT
admet-470	129	16	house	house	NOUN
admet-470	129	17	in	in	ADP
admet-470	129	18	silico	silico	NOUN
admet-470	129	19	adme	adme	NOUN
admet-470	129	20	models	model	NOUN
admet-470	129	21	drug	drug	NOUN
admet-470	129	22	name	name	NOUN
admet-470	129	23	clinthh	clinthh	ADJ
admet-470	129	24	a	a	DET
admet-470	129	25	(	(	PUNCT
admet-470	129	26	l	l	PROPN
admet-470	129	27	/	/	SYM
admet-470	129	28	min/106	min/106	NOUN
admet-470	129	29	cells	cell	NOUN
admet-470	129	30	)	)	PUNCT
admet-470	129	31	fuinc	fuinc	PROPN
admet-470	130	1	b	b	PROPN
admet-470	130	2	%	%	NOUN
admet-470	130	3	free	free	ADJ
admet-470	130	4	fuc	fuc	ADJ
admet-470	130	5	%	%	ADJ
admet-470	130	6	free	free	ADJ
admet-470	130	7	papp	papp	PROPN
admet-470	130	8	d	d	X
admet-470	130	9	(	(	PUNCT
admet-470	130	10	10	10	NUM
admet-470	130	11	-	-	SYM
admet-470	130	12	6	6	NUM
admet-470	130	13	cm	cm	NOUN
admet-470	130	14	/	/	SYM
admet-470	130	15	sec	sec	PROPN
admet-470	130	16	)	)	PUNCT
admet-470	130	17	ve	ve	NOUN
admet-470	130	18	(	(	PUNCT
admet-470	130	19	l	l	NOUN
admet-470	130	20	/	/	SYM
admet-470	130	21	kg	kg	NOUN
admet-470	130	22	)	)	PUNCT
admet-470	130	23	mwf	mwf	NOUN
admet-470	130	24	(	(	PUNCT
admet-470	130	25	g	g	NOUN
admet-470	130	26	/	/	SYM
admet-470	130	27	mol	mol	NOUN
admet-470	130	28	)	)	PUNCT
admet-470	130	29	ion	ion	NOUN
admet-470	130	30	class	class	NOUN
admet-470	130	31	acebutolol	acebutolol	NOUN
admet-470	130	32	7.7	7.7	NUM
admet-470	130	33	79.0	79.0	NUM
admet-470	130	34	80.8	80.8	NUM
admet-470	130	35	2.5	2.5	NUM
admet-470	130	36	1.5	1.5	NUM
admet-470	130	37	336.4	336.4	NUM
admet-470	130	38	base	base	NOUN
admet-470	130	39	atenolol	atenolol	PROPN
admet-470	130	40	1.6	1.6	NUM
admet-470	130	41	89.7	89.7	NUM
admet-470	130	42	92.4	92.4	NUM
admet-470	130	43	0.3	0.3	NUM
admet-470	130	44	1.5	1.5	NUM
admet-470	130	45	266.3	266.3	NUM
admet-470	130	46	base	base	NOUN
admet-470	130	47	betaxolol	betaxolol	NOUN
admet-470	130	48	10.0	10.0	NUM
admet-470	130	49	82.1	82.1	NUM
admet-470	130	50	51.0	51.0	NUM
admet-470	130	51	17.6	17.6	NUM
admet-470	130	52	3.8	3.8	NUM
admet-470	130	53	307.4	307.4	NUM
admet-470	130	54	base	base	NOUN
admet-470	130	55	bisoprolol	bisoprolol	VERB
admet-470	130	56	9.5	9.5	NUM
admet-470	130	57	82.1	82.1	NUM
admet-470	130	58	63.8	63.8	NUM
admet-470	130	59	12.6	12.6	NUM
admet-470	130	60	2.3	2.3	NUM
admet-470	130	61	325.4	325.4	NUM
admet-470	130	62	base	base	NOUN
admet-470	130	63	carvedilol	carvedilol	NOUN
admet-470	130	64	25.0	25.0	NUM
admet-470	130	65	19.5	19.5	NUM
admet-470	130	66	0.6	0.6	NUM
admet-470	130	67	4.8	4.8	NUM
admet-470	130	68	1.9	1.9	NUM
admet-470	130	69	406.5	406.5	NUM
admet-470	130	70	base	base	NOUN
admet-470	130	71	cimetidine	cimetidine	NOUN
admet-470	130	72	5.2	5.2	NUM
admet-470	130	73	77.7	77.7	NUM
admet-470	130	74	81.2	81.2	NUM
admet-470	130	75	4.8	4.8	NUM
admet-470	130	76	1.0	1.0	NUM
admet-470	130	77	252.3	252.3	NUM
admet-470	130	78	base	base	NOUN
admet-470	130	79	cyclosporin	cyclosporin	NOUN
admet-470	130	80	738.4	738.4	NUM
admet-470	130	81	97.4	97.4	NUM
admet-470	130	82	0.5	0.5	NUM
admet-470	130	83	1.4	1.4	NUM
admet-470	130	84	2.0	2.0	NUM
admet-470	130	85	1203	1203	NUM
admet-470	130	86	neutral	neutral	ADJ
admet-470	130	87	desloratidine	desloratidine	NOUN
admet-470	130	88	9.2	9.2	NUM
admet-470	130	89	11.9	11.9	NUM
admet-470	130	90	7.8	7.8	NUM
admet-470	130	91	19.4	19.4	NUM
admet-470	130	92	7.8	7.8	NUM
admet-470	130	93	310.8	310.8	NUM
admet-470	130	94	base	base	NOUN
admet-470	130	95	diazepam	diazepam	VERB
admet-470	130	96	6.5	6.5	NUM
admet-470	130	97	14.6	14.6	NUM
admet-470	130	98	3.7	3.7	NUM
admet-470	130	99	55.3	55.3	NUM
admet-470	130	100	1.1	1.1	NUM
admet-470	130	101	284.7	284.7	NUM
admet-470	130	102	neutral	neutral	ADJ
admet-470	130	103	diclofenac	diclofenac	VERB
admet-470	130	104	55.2	55.2	NUM
admet-470	130	105	52.8	52.8	NUM
admet-470	130	106	1.8	1.8	NUM
admet-470	130	107	33.8	33.8	NUM
admet-470	130	108	0.3	0.3	NUM
admet-470	130	109	296.2	296.2	NUM
admet-470	130	110	acid	acid	NOUN
admet-470	130	111	famotidine	famotidine	NOUN
admet-470	130	112	2.5	2.5	NUM
admet-470	130	113	77.6	77.6	NUM
admet-470	130	114	78.1	78.1	NUM
admet-470	130	115	0.7	0.7	NUM
admet-470	130	116	0.9	0.9	NUM
admet-470	130	117	337.5	337.5	NUM
admet-470	130	118	base	base	NOUN
admet-470	130	119	indomethacin	indomethacin	VERB
admet-470	130	120	7.5	7.5	NUM
admet-470	130	121	39.7	39.7	NUM
admet-470	130	122	0.6	0.6	NUM
admet-470	130	123	74.1	74.1	NUM
admet-470	130	124	0.2	0.2	NUM
admet-470	130	125	357.8	357.8	NUM
admet-470	130	126	acid	acid	NOUN
admet-470	130	127	irbesartan	irbesartan	NOUN
admet-470	130	128	15.1	15.1	NUM
admet-470	130	129	17.7	17.7	NUM
admet-470	130	130	0.8	0.8	NUM
admet-470	130	131	15.6	15.6	NUM
admet-470	130	132	0.9	0.9	NUM
admet-470	130	133	428.5	428.5	NUM
admet-470	130	134	acid	acid	NOUN
admet-470	130	135	metoprolol	metoprolol	PROPN
admet-470	130	136	4.9	4.9	NUM
admet-470	130	137	87.3	87.3	NUM
admet-470	130	138	73.1	73.1	NUM
admet-470	130	139	13.4	13.4	NUM
admet-470	130	140	2.4	2.4	NUM
admet-470	130	141	267.4	267.4	NUM
admet-470	130	142	base	base	NOUN
admet-470	130	143	nadolol	nadolol	VERB
admet-470	130	144	4.4	4.4	NUM
admet-470	130	145	79.8	79.8	NUM
admet-470	130	146	76.9	76.9	NUM
admet-470	130	147	0.4	0.4	NUM
admet-470	130	148	2.1	2.1	NUM
admet-470	130	149	309.4	309.4	NUM
admet-470	130	150	base	base	NOUN
admet-470	130	151	nifedipine	nifedipine	NOUN
admet-470	130	152	14.3	14.3	NUM
admet-470	130	153	30.7	30.7	NUM
admet-470	130	154	3.5	3.5	NUM
admet-470	130	155	45.0	45.0	NUM
admet-470	130	156	1.2	1.2	NUM
admet-470	130	157	346.3	346.3	NUM
admet-470	130	158	neutral	neutral	ADJ
admet-470	130	159	pirenzepine	pirenzepine	NOUN
admet-470	130	160	8.5	8.5	NUM
admet-470	130	161	86.8	86.8	NUM
admet-470	130	162	50.7	50.7	NUM
admet-470	130	163	0.5	0.5	NUM
admet-470	130	164	1.7	1.7	NUM
admet-470	130	165	351.4	351.4	NUM
admet-470	130	166	base	base	NOUN
admet-470	130	167	prazosin	prazosin	NOUN
admet-470	131	1	6.5	6.5	NUM
admet-470	131	2	58.8	58.8	NUM
admet-470	131	3	9.9	9.9	NUM
admet-470	131	4	10.1	10.1	NUM
admet-470	131	5	0.8	0.8	NUM
admet-470	131	6	383.4	383.4	NUM
admet-470	131	7	neutral	neutral	ADJ
admet-470	131	8	propranolol	propranolol	NOUN
admet-470	131	9	9.5	9.5	NUM
admet-470	131	10	59.5	59.5	NUM
admet-470	131	11	18.8	18.8	NUM
admet-470	131	12	31.0	31.0	NUM
admet-470	131	13	3.0	3.0	NUM
admet-470	131	14	259.3	259.3	NUM
admet-470	131	15	base	base	NOUN
admet-470	131	16	ranitidine	ranitidine	NOUN
admet-470	131	17	5.6	5.6	NUM
admet-470	131	18	69.4	69.4	NUM
admet-470	131	19	80.2	80.2	NUM
admet-470	131	20	2.2	2.2	NUM
admet-470	131	21	1.2	1.2	NUM
admet-470	131	22	314.4	314.4	NUM
admet-470	131	23	base	base	NOUN
admet-470	131	24	ritonavir	ritonavir	PROPN
admet-470	131	25	75.3	75.3	NUM
admet-470	131	26	19.1	19.1	NUM
admet-470	131	27	1.1	1.1	NUM
admet-470	131	28	4.0	4.0	NUM
admet-470	131	29	0.9	0.9	NUM
admet-470	131	30	721	721	NUM
admet-470	131	31	neutral	neutral	ADJ
admet-470	131	32	a	a	DET
admet-470	131	33	clinthh	clinthh	ADJ
admet-470	131	34	:	:	PUNCT
admet-470	131	35	intrinsic	intrinsic	ADJ
admet-470	131	36	clearance	clearance	NOUN
admet-470	131	37	in	in	ADP
admet-470	131	38	human	human	ADJ
admet-470	131	39	hepatocytes	hepatocyte	NOUN
admet-470	131	40	;	;	PUNCT
admet-470	131	41	b	b	X
admet-470	131	42	fuinc	fuinc	PROPN
admet-470	131	43	:	:	PUNCT
admet-470	131	44	fraction	fraction	NOUN
admet-470	131	45	unbound	unbound	NOUN
admet-470	131	46	in	in	ADP
admet-470	131	47	rat	rat	NOUN
admet-470	131	48	hepatocyte	hepatocyte	NOUN
admet-470	131	49	incubation	incubation	NOUN
admet-470	131	50	;	;	PUNCT
admet-470	131	51	c	c	PROPN
admet-470	131	52	fu	fu	NOUN
admet-470	131	53	:	:	PUNCT
admet-470	131	54	fraction	fraction	NOUN
admet-470	131	55	unbound	unbound	NOUN
admet-470	131	56	in	in	ADP
admet-470	131	57	human	human	ADJ
admet-470	131	58	blood	blood	NOUN
admet-470	131	59	plasma	plasma	NOUN
admet-470	131	60	;	;	PUNCT
admet-470	131	61	d	d	X
admet-470	131	62	papp	papp	NOUN
admet-470	131	63	:	:	PUNCT
admet-470	131	64	apparent	apparent	ADJ
admet-470	131	65	permeability	permeability	NOUN
admet-470	131	66	in	in	ADP
admet-470	131	67	caco2	caco2	NOUN
admet-470	131	68	cells	cell	NOUN
admet-470	131	69	with	with	ADP
admet-470	131	70	transport	transport	NOUN
admet-470	131	71	inhibition	inhibition	NOUN
admet-470	131	72	;	;	PUNCT
admet-470	131	73	e	e	X
admet-470	131	74	v	v	NOUN
admet-470	131	75	:	:	PUNCT
admet-470	131	76	human	human	ADJ
admet-470	131	77	volume	volume	NOUN
admet-470	131	78	of	of	ADP
admet-470	131	79	distribution	distribution	NOUN
admet-470	131	80	at	at	ADP
admet-470	131	81	steady	steady	ADJ
admet-470	131	82	state	state	NOUN
admet-470	131	83	;	;	PUNCT
admet-470	131	84	f	f	PROPN
admet-470	131	85	mw	mw	X
admet-470	131	86	:	:	PUNCT
admet-470	131	87	molecular	molecular	ADJ
admet-470	131	88	weight	weight	NOUN
admet-470	131	89	.	.	PUNCT
admet-470	132	1	to	to	PART
admet-470	132	2	take	take	VERB
admet-470	132	3	into	into	ADP
admet-470	132	4	account	account	NOUN
admet-470	132	5	that	that	SCONJ
admet-470	132	6	these	these	DET
admet-470	132	7	drugs	drug	NOUN
admet-470	132	8	are	be	AUX
admet-470	132	9	not	not	PART
admet-470	132	10	necessarily	necessarily	ADV
admet-470	132	11	given	give	VERB
admet-470	132	12	once	once	ADV
admet-470	132	13	daily	daily	ADV
admet-470	132	14	only	only	ADV
admet-470	132	15	,	,	PUNCT
admet-470	132	16	we	we	PRON
admet-470	132	17	adopted	adopt	VERB
admet-470	132	18	the	the	DET
admet-470	132	19	dosing	dose	VERB
admet-470	132	20	regimen	regimen	NOUN
admet-470	132	21	suggestion	suggestion	NOUN
admet-470	132	22	by	by	ADP
admet-470	132	23	mcginnity	mcginnity	NOUN
admet-470	132	24	et	et	PROPN
admet-470	132	25	al	al	PROPN
admet-470	132	26	.	.	PUNCT
admet-470	133	1	[	[	X
admet-470	133	2	9	9	NUM
admet-470	133	3	]	]	PUNCT
admet-470	133	4	when	when	SCONJ
admet-470	133	5	calculating	calculate	VERB
admet-470	133	6	the	the	DET
admet-470	133	7	minimum	minimum	ADJ
admet-470	133	8	required	require	VERB
admet-470	133	9	potency	potency	NOUN
admet-470	133	10	,	,	PUNCT
admet-470	133	11	threshold	threshold	NOUN
admet-470	133	12	px	px	X
admet-470	133	13	(	(	PUNCT
admet-470	133	14	see	see	VERB
admet-470	133	15	table	table	NOUN
admet-470	133	16	4	4	NUM
admet-470	133	17	)	)	PUNCT
admet-470	133	18	.	.	PUNCT
admet-470	134	1	the	the	DET
admet-470	134	2	resulting	result	VERB
admet-470	134	3	threshold	threshold	NOUN
admet-470	134	4	px	px	PROPN
admet-470	134	5	values	value	NOUN
admet-470	134	6	are	be	AUX
admet-470	134	7	below	below	ADP
admet-470	134	8	10	10	NUM
admet-470	134	9	for	for	ADP
admet-470	134	10	all	all	PRON
admet-470	134	11	but	but	SCONJ
admet-470	134	12	four	four	NUM
admet-470	134	13	of	of	ADP
admet-470	134	14	the	the	DET
admet-470	134	15	compounds	compound	NOUN
admet-470	134	16	,	,	PUNCT
admet-470	134	17	thus	thus	ADV
admet-470	134	18	indicating	indicate	VERB
admet-470	134	19	that	that	SCONJ
admet-470	134	20	the	the	DET
admet-470	134	21	approach	approach	NOUN
admet-470	134	22	is	be	AUX
admet-470	134	23	able	able	ADJ
admet-470	134	24	to	to	PART
admet-470	134	25	estimate	estimate	VERB
admet-470	134	26	pharmacokinetic	pharmacokinetic	ADJ
admet-470	134	27	behaviour	behaviour	NOUN
admet-470	134	28	to	to	ADP
admet-470	134	29	some	some	DET
admet-470	134	30	extent	extent	NOUN
admet-470	134	31	.	.	PUNCT
admet-470	135	1	additionally	additionally	ADV
admet-470	135	2	,	,	PUNCT
admet-470	135	3	the	the	DET
admet-470	135	4	cmax	cmax	NOUN
admet-470	135	5	/	/	SYM
admet-470	135	6	cmin	cmin	NOUN
admet-470	135	7	ratio	ratio	NOUN
admet-470	135	8	was	be	AUX
admet-470	135	9	estimated	estimate	VERB
admet-470	135	10	as	as	ADP
admet-470	135	11	below	below	ADP
admet-470	135	12	100	100	NUM
admet-470	135	13	for	for	ADP
admet-470	135	14	most	most	ADJ
admet-470	135	15	of	of	ADP
admet-470	135	16	the	the	DET
admet-470	135	17	compounds	compound	NOUN
admet-470	135	18	,	,	PUNCT
admet-470	135	19	even	even	ADV
admet-470	135	20	though	though	SCONJ
admet-470	135	21	it	it	PRON
admet-470	135	22	showed	show	VERB
admet-470	135	23	values	value	NOUN
admet-470	135	24	above	above	ADP
admet-470	135	25	1000	1000	NUM
admet-470	135	26	for	for	ADP
admet-470	135	27	three	three	NUM
admet-470	135	28	of	of	ADP
admet-470	135	29	them	they	PRON
admet-470	135	30	(	(	PUNCT
admet-470	135	31	ritonavir	ritonavir	PROPN
admet-470	135	32	,	,	PUNCT
admet-470	135	33	bisoprolol	bisoprolol	NOUN
admet-470	135	34	and	and	CCONJ
admet-470	135	35	diclofenac	diclofenac	NOUN
admet-470	135	36	)	)	PUNCT
admet-470	135	37	.	.	PUNCT
admet-470	136	1	the	the	DET
admet-470	136	2	availability	availability	NOUN
admet-470	136	3	of	of	ADP
admet-470	136	4	both	both	PRON
admet-470	136	5	in	in	ADP
admet-470	136	6	vitro	vitro	X
admet-470	136	7	[	[	X
admet-470	136	8	10	10	NUM
admet-470	136	9	]	]	PUNCT
admet-470	136	10	and	and	CCONJ
admet-470	136	11	in	in	ADP
admet-470	136	12	vivo	vivo	NOUN
admet-470	136	13	[	[	X
admet-470	136	14	9	9	NUM
admet-470	136	15	]	]	PUNCT
admet-470	136	16	data	datum	NOUN
admet-470	136	17	for	for	ADP
admet-470	136	18	the	the	DET
admet-470	136	19	compounds	compound	NOUN
admet-470	136	20	prompted	prompt	VERB
admet-470	136	21	us	we	PRON
admet-470	136	22	to	to	PART
admet-470	136	23	investigate	investigate	VERB
admet-470	136	24	,	,	PUNCT
admet-470	136	25	to	to	ADP
admet-470	136	26	what	what	DET
admet-470	136	27	extent	extent	NOUN
admet-470	136	28	the	the	DET
admet-470	136	29	usage	usage	NOUN
admet-470	136	30	of	of	ADP
admet-470	136	31	experimental	experimental	ADJ
admet-470	136	32	data	datum	NOUN
admet-470	136	33	would	would	AUX
admet-470	136	34	change	change	VERB
admet-470	136	35	the	the	DET
admet-470	136	36	results	result	NOUN
admet-470	136	37	(	(	PUNCT
admet-470	136	38	see	see	VERB
admet-470	136	39	table	table	NOUN
admet-470	136	40	5	5	NUM
admet-470	136	41	and	and	CCONJ
admet-470	136	42	figure	figure	VERB
admet-470	136	43	1	1	NUM
admet-470	136	44	)	)	PUNCT
admet-470	136	45	.	.	PUNCT
admet-470	137	1	susanne	susanne	PROPN
admet-470	137	2	winiwarter	winiwarter	PROPN
admet-470	137	3	et	et	PROPN
admet-470	137	4	al	al	PROPN
admet-470	137	5	.	.	PROPN
admet-470	137	6	admet	admet	PROPN
admet-470	137	7	&	&	CCONJ
admet-470	137	8	dmpk	dmpk	PROPN
admet-470	137	9	6(1	6(1	NUM
admet-470	137	10	)	)	PUNCT
admet-470	137	11	(	(	PUNCT
admet-470	137	12	2018	2018	NUM
admet-470	137	13	)	)	PUNCT
admet-470	137	14	15	15	NUM
admet-470	137	15	-	-	SYM
admet-470	137	16	33	33	NUM
admet-470	137	17	24	24	NUM
admet-470	137	18	table	table	NOUN
admet-470	137	19	4	4	NUM
admet-470	137	20	.	.	PUNCT
admet-470	137	21	dosing	dose	VERB
admet-470	137	22	interval	interval	NOUN
admet-470	137	23	,	,	PUNCT
admet-470	137	24	predicted	predict	VERB
admet-470	137	25	plasma	plasma	NOUN
admet-470	137	26	concentrations	concentration	NOUN
admet-470	137	27	and	and	CCONJ
admet-470	137	28	threshold	threshold	NOUN
admet-470	137	29	px	px	NOUN
admet-470	137	30	based	base	VERB
admet-470	137	31	on	on	ADP
admet-470	137	32	a	a	DET
admet-470	137	33	daily	daily	ADJ
admet-470	137	34	dose	dose	NOUN
admet-470	137	35	of	of	ADP
admet-470	137	36	100	100	NUM
admet-470	137	37	mg	mg	PROPN
admet-470	137	38	(	(	PUNCT
admet-470	137	39	1.4	1.4	NUM
admet-470	137	40	mg	mg	PROPN
admet-470	137	41	/	/	SYM
admet-470	137	42	kg	kg	PROPN
admet-470	137	43	)	)	PUNCT
admet-470	137	44	,	,	PUNCT
admet-470	137	45	given	give	VERB
admet-470	137	46	as	as	ADP
admet-470	137	47	1	1	NUM
admet-470	137	48	-	-	SYM
admet-470	137	49	6	6	NUM
admet-470	137	50	doses	dose	NOUN
admet-470	137	51	per	per	ADP
admet-470	137	52	day	day	NOUN
admet-470	137	53	,	,	PUNCT
admet-470	137	54	for	for	ADP
admet-470	137	55	21	21	NUM
admet-470	137	56	known	know	VERB
admet-470	137	57	drugs	drug	NOUN
admet-470	137	58	[	[	X
admet-470	137	59	9	9	NUM
admet-470	137	60	]	]	PUNCT
admet-470	137	61	drug	drug	NOUN
admet-470	137	62	name	name	NOUN
admet-470	137	63	dosing	dose	VERB
admet-470	137	64	intervala	intervala	NOUN
admet-470	137	65	(	(	PUNCT
admet-470	137	66	h	h	NOUN
admet-470	137	67	)	)	PUNCT
admet-470	137	68	cmin	cmin	NOUN
admet-470	137	69	,	,	PUNCT
admet-470	137	70	total	total	NOUN
admet-470	137	71	b	b	X
admet-470	137	72	(	(	PUNCT
admet-470	137	73	m	m	PROPN
admet-470	137	74	)	)	PUNCT
admet-470	137	75	cmin	cmin	NOUN
admet-470	137	76	,	,	PUNCT
admet-470	137	77	free	free	ADJ
admet-470	137	78	c	c	PROPN
admet-470	137	79	(	(	PUNCT
admet-470	137	80	m	m	PROPN
admet-470	137	81	)	)	PUNCT
admet-470	137	82	cmax	cmax	NOUN
admet-470	137	83	,	,	PUNCT
admet-470	137	84	total	total	ADJ
admet-470	137	85	d	d	X
admet-470	137	86	(	(	PUNCT
admet-470	137	87	m	m	NOUN
admet-470	137	88	)	)	PUNCT
admet-470	137	89	threshold	threshold	NOUN
admet-470	137	90	px	px	PROPN
admet-470	137	91	from	from	ADP
admet-470	137	92	cmin	cmin	NOUN
admet-470	137	93	,	,	PUNCT
admet-470	137	94	free	free	ADJ
admet-470	137	95	e	e	NOUN
admet-470	137	96	cmax	cmax	X
admet-470	137	97	/	/	SYM
admet-470	137	98	cmin	cmin	PROPN
admet-470	137	99	f	f	PROPN
admet-470	137	100	acebutolol	acebutolol	PROPN
admet-470	137	101	8	8	NUM
admet-470	137	102	0.00165	0.00165	NUM
admet-470	137	103	0.00134	0.00134	NUM
admet-470	137	104	0.21153	0.21153	NUM
admet-470	137	105	8.9	8.9	NUM
admet-470	137	106	127.9	127.9	NUM
admet-470	137	107	atenolol	atenolol	NOUN
admet-470	137	108	12	12	NUM
admet-470	137	109	0.00742	0.00742	NUM
admet-470	137	110	0.00686	0.00686	NUM
admet-470	137	111	0.35626	0.35626	NUM
admet-470	137	112	8.2	8.2	NUM
admet-470	137	113	48.0	48.0	NUM
admet-470	137	114	betaxolol	betaxolol	NOUN
admet-470	137	115	12	12	NUM
admet-470	137	116	0.01102	0.01102	NUM
admet-470	137	117	0.00563	0.00563	NUM
admet-470	137	118	0.17910	0.17910	NUM
admet-470	137	119	8.2	8.2	NUM
admet-470	137	120	16.3	16.3	NUM
admet-470	137	121	bisoprolol	bisoprolol	NOUN
admet-470	137	122	24	24	NUM
admet-470	137	123	0.00004	0.00004	NUM
admet-470	137	124	0.00002	0.00002	NUM
admet-470	137	125	0.44702	0.44702	NUM
admet-470	137	126	10.6	10.6	NUM
admet-470	137	127	11795.4	11795.4	NUM
admet-470	137	128	carvedilol	carvedilol	NOUN
admet-470	137	129	8	8	NUM
admet-470	137	130	0.19649	0.19649	NUM
admet-470	137	131	0.00114	0.00114	NUM
admet-470	137	132	0.65630	0.65630	NUM
admet-470	137	133	8.9	8.9	NUM
admet-470	137	134	3.3	3.3	NUM
admet-470	137	135	cimetidine	cimetidine	NOUN
admet-470	137	136	4	4	NUM
admet-470	137	137	0.01081	0.01081	NUM
admet-470	137	138	0.00878	0.00878	NUM
admet-470	137	139	0.28422	0.28422	NUM
admet-470	137	140	8.1	8.1	NUM
admet-470	137	141	26.3	26.3	NUM
admet-470	137	142	cyclosporin	cyclosporin	NOUN
admet-470	137	143	12	12	NUM
admet-470	137	144	0.00155	0.00155	NUM
admet-470	137	145	0.00001	0.00001	NUM
admet-470	137	146	0.12384	0.12384	NUM
admet-470	137	147	11.2	11.2	NUM
admet-470	137	148	79.9	79.9	NUM
admet-470	137	149	desloratidine	desloratidine	NOUN
admet-470	137	150	24	24	NUM
admet-470	137	151	0.01218	0.01218	NUM
admet-470	137	152	0.00095	0.00095	NUM
admet-470	137	153	0.17440	0.17440	NUM
admet-470	137	154	9.0	9.0	NUM
admet-470	137	155	14.3	14.3	NUM
admet-470	137	156	diazepam	diazepam	NOUN
admet-470	137	157	12	12	NUM
admet-470	137	158	0.00572	0.00572	NUM
admet-470	137	159	0.00021	0.00021	NUM
admet-470	137	160	1.35487	1.35487	NUM
admet-470	137	161	9.7	9.7	NUM
admet-470	137	162	236.9	236.9	NUM
admet-470	137	163	diclofenac	diclofenac	NOUN
admet-470	137	164	4	4	NUM
admet-470	137	165	0.00002	0.00002	NUM
admet-470	137	166	0.00000	0.00000	NUM
admet-470	137	167	1.26227	1.26227	NUM
admet-470	137	168	12.4	12.4	NUM
admet-470	137	169	55501.6	55501.6	NUM
admet-470	137	170	famotidine	famotidine	NOUN
admet-470	137	171	6	6	NUM
admet-470	137	172	0.00631	0.00631	NUM
admet-470	137	173	0.00493	0.00493	NUM
admet-470	137	174	0.42939	0.42939	NUM
admet-470	137	175	8.3	8.3	NUM
admet-470	137	176	68.1	68.1	NUM
admet-470	137	177	indomethacin	indomethacin	VERB
admet-470	137	178	6	6	NUM
admet-470	137	179	0.16284	0.16284	NUM
admet-470	137	180	0.00095	0.00095	NUM
admet-470	137	181	5.90360	5.90360	NUM
admet-470	137	182	9.0	9.0	NUM
admet-470	137	183	36.3	36.3	NUM
admet-470	137	184	irbesartan	irbesartan	ADJ
admet-470	137	185	8	8	NUM
admet-470	137	186	0.01792	0.01792	NUM
admet-470	137	187	0.00015	0.00015	NUM
admet-470	138	1	0.82347	0.82347	NUM
admet-470	138	2	9.8	9.8	NUM
admet-470	138	3	46.0	46.0	NUM
admet-470	138	4	metoprolol	metoprolol	NOUN
admet-470	138	5	8	8	NUM
admet-470	138	6	0.02235	0.02235	NUM
admet-470	138	7	0.01635	0.01635	NUM
admet-470	138	8	0.29316	0.29316	NUM
admet-470	138	9	7.8	7.8	NUM
admet-470	138	10	13.1	13.1	NUM
admet-470	138	11	nadolol	nadolol	NOUN
admet-470	138	12	8	8	NUM
admet-470	138	13	0.00547	0.00547	NUM
admet-470	138	14	0.00421	0.00421	NUM
admet-470	138	15	0.10158	0.10158	NUM
admet-470	138	16	8.4	8.4	NUM
admet-470	138	17	18.6	18.6	NUM
admet-470	138	18	nifedipine	nifedipine	NOUN
admet-470	138	19	6	6	NUM
admet-470	138	20	0.04706	0.04706	NUM
admet-470	138	21	0.00164	0.00164	NUM
admet-470	138	22	0.54780	0.54780	NUM
admet-470	138	23	8.8	8.8	NUM
admet-470	138	24	11.6	11.6	NUM
admet-470	138	25	pirenzepine	pirenzepine	NOUN
admet-470	138	26	12	12	NUM
admet-470	138	27	0.00055	0.00055	NUM
admet-470	138	28	0.00028	0.00028	NUM
admet-470	138	29	0.18872	0.18872	NUM
admet-470	138	30	9.6	9.6	NUM
admet-470	138	31	345.6	345.6	NUM
admet-470	138	32	prazosin	prazosin	NOUN
admet-470	138	33	6	6	NUM
admet-470	138	34	0.04517	0.04517	NUM
admet-470	138	35	0.00448	0.00448	NUM
admet-470	138	36	0.84533	0.84533	NUM
admet-470	138	37	8.3	8.3	NUM
admet-470	138	38	18.7	18.7	NUM
admet-470	138	39	propranolol	propranolol	NOUN
admet-470	138	40	8	8	NUM
admet-470	138	41	0.05111	0.05111	NUM
admet-470	138	42	0.00961	0.00961	NUM
admet-470	138	43	0.32040	0.32040	NUM
admet-470	138	44	8.0	8.0	NUM
admet-470	138	45	6.3	6.3	NUM
admet-470	138	46	ranitidine	ranitidine	NOUN
admet-470	138	47	6	6	NUM
admet-470	138	48	0.00271	0.00271	NUM
admet-470	138	49	0.00218	0.00218	NUM
admet-470	138	50	0.26131	0.26131	NUM
admet-470	138	51	8.7	8.7	NUM
admet-470	138	52	96.3	96.3	NUM
admet-470	138	53	ritonavir	ritonavir	PROPN
admet-470	138	54	8	8	NUM
admet-470	138	55	0.00021	0.00021	NUM
admet-470	138	56	0.00000	0.00000	NUM
admet-470	138	57	0.26073	0.26073	NUM
admet-470	138	58	11.6	11.6	NUM
admet-470	138	59	1239.4	1239.4	NUM
admet-470	138	60	a	a	DET
admet-470	138	61	dosing	dosing	NOUN
admet-470	138	62	interval	interval	NOUN
admet-470	138	63	as	as	SCONJ
admet-470	138	64	suggested	suggest	VERB
admet-470	138	65	by	by	ADP
admet-470	138	66	mcginnity	mcginnity	NOUN
admet-470	138	67	et	et	PROPN
admet-470	138	68	al	al	PROPN
admet-470	138	69	.	.	PUNCT
admet-470	139	1	[	[	X
admet-470	139	2	9	9	NUM
admet-470	139	3	]	]	PUNCT
admet-470	139	4	,	,	PUNCT
admet-470	139	5	based	base	VERB
admet-470	139	6	on	on	ADP
admet-470	139	7	their	their	PRON
admet-470	139	8	predicted	predict	VERB
admet-470	139	9	t1/2	t1/2	NOUN
admet-470	139	10	:	:	PUNCT
admet-470	139	11	t1/2>8h	t1/2>8h	PROPN
admet-470	139	12			PROPN
admet-470	139	13	24h	24h	NOUN
admet-470	139	14	;	;	PUNCT
admet-470	139	15	t1/2	t1/2	VERB
admet-470	139	16	4	4	NUM
admet-470	139	17	-	-	SYM
admet-470	139	18	8	8	NUM
admet-470	139	19	h	h	NOUN
admet-470	139	20			NOUN
admet-470	139	21	12h	12h	NUM
admet-470	139	22	;	;	PUNCT
admet-470	139	23	t1/2	t1/2	ADJ
admet-470	139	24	2	2	NUM
admet-470	139	25	-	-	SYM
admet-470	139	26	4h	4h	NUM
admet-470	139	27			NOUN
admet-470	139	28	8h	8h	NUM
admet-470	139	29	;	;	PUNCT
admet-470	139	30	t1/2	t1/2	NUM
admet-470	139	31	1	1	NUM
admet-470	139	32	-	-	SYM
admet-470	139	33	2	2	NUM
admet-470	139	34	h	h	NOUN
admet-470	139	35			NOUN
admet-470	139	36	6h	6h	NUM
admet-470	139	37	;	;	PUNCT
admet-470	139	38	t1/2	t1/2	VERB
admet-470	139	39	<	<	X
admet-470	139	40	1h	1h	NUM
admet-470	139	41			PROPN
admet-470	139	42	4h	4h	NUM
admet-470	139	43	;	;	PUNCT
admet-470	139	44	b	b	X
admet-470	139	45	cmin	cmin	NOUN
admet-470	139	46	,	,	PUNCT
admet-470	139	47	total	total	NOUN
admet-470	139	48	:	:	PUNCT
admet-470	139	49	predicted	predict	VERB
admet-470	139	50	minimum	minimum	ADJ
admet-470	139	51	total	total	ADJ
admet-470	139	52	concentration	concentration	NOUN
admet-470	139	53	at	at	ADP
admet-470	139	54	steady	steady	ADJ
admet-470	139	55	state	state	NOUN
admet-470	139	56	;	;	PUNCT
admet-470	139	57	c	c	PROPN
admet-470	139	58	cmin	cmin	NOUN
admet-470	139	59	,	,	PUNCT
admet-470	139	60	free	free	ADJ
admet-470	139	61	:	:	PUNCT
admet-470	139	62	predicted	predict	VERB
admet-470	139	63	minimum	minimum	ADJ
admet-470	139	64	concentration	concentration	NOUN
admet-470	139	65	at	at	ADP
admet-470	139	66	steady	steady	ADJ
admet-470	139	67	state	state	NOUN
admet-470	139	68	corrected	correct	VERB
admet-470	139	69	for	for	ADP
admet-470	139	70	plasma	plasma	NOUN
admet-470	139	71	protein	protein	NOUN
admet-470	139	72	binding	bind	VERB
admet-470	139	73	;	;	PUNCT
admet-470	139	74	d	d	X
admet-470	139	75	cmax	cmax	NOUN
admet-470	139	76	,	,	PUNCT
admet-470	139	77	total	total	NOUN
admet-470	139	78	:	:	PUNCT
admet-470	139	79	predicted	predict	VERB
admet-470	139	80	maximum	maximum	ADJ
admet-470	139	81	total	total	ADJ
admet-470	139	82	concentration	concentration	NOUN
admet-470	139	83	at	at	ADP
admet-470	139	84	steady	steady	ADJ
admet-470	139	85	state	state	NOUN
admet-470	139	86	;	;	PUNCT
admet-470	139	87	e	e	X
admet-470	139	88	threshold	threshold	NOUN
admet-470	139	89	px	px	PROPN
admet-470	139	90	from	from	ADP
admet-470	139	91	cmin	cmin	NOUN
admet-470	139	92	,	,	PUNCT
admet-470	139	93	free	free	ADJ
admet-470	139	94	:	:	PUNCT
admet-470	139	95	required	require	VERB
admet-470	139	96	minimum	minimum	NOUN
admet-470	139	97	px	px	NOUN
admet-470	139	98	estimated	estimate	VERB
admet-470	139	99	from	from	ADP
admet-470	139	100	free	free	ADJ
admet-470	139	101	cmin	cmin	NOUN
admet-470	139	102	for	for	ADP
admet-470	139	103	coverage	coverage	NOUN
admet-470	139	104	over	over	ADP
admet-470	139	105	dosing	dose	VERB
admet-470	139	106	interval	interval	NOUN
admet-470	139	107	;	;	PUNCT
admet-470	140	1	f	f	X
admet-470	140	2	cmax	cmax	NOUN
admet-470	140	3	/	/	SYM
admet-470	140	4	cmin	cmin	NOUN
admet-470	140	5	:	:	PUNCT
admet-470	140	6	predicted	predict	VERB
admet-470	140	7	ratio	ratio	NOUN
admet-470	140	8	between	between	ADP
admet-470	140	9	maximum	maximum	ADJ
admet-470	140	10	and	and	CCONJ
admet-470	140	11	minimum	minimum	ADJ
admet-470	140	12	total	total	ADJ
admet-470	140	13	concentration	concentration	NOUN
admet-470	140	14	at	at	ADP
admet-470	140	15	steady	steady	ADJ
admet-470	140	16	state	state	NOUN
admet-470	140	17	.	.	PUNCT
admet-470	141	1	admet	admet	PROPN
admet-470	141	2	&	&	CCONJ
admet-470	141	3	dmpk	dmpk	PROPN
admet-470	141	4	6(1	6(1	NUM
admet-470	141	5	)	)	PUNCT
admet-470	141	6	(	(	PUNCT
admet-470	141	7	2018	2018	NUM
admet-470	141	8	)	)	PUNCT
admet-470	141	9	15	15	NUM
admet-470	141	10	-	-	SYM
admet-470	141	11	33	33	NUM
admet-470	141	12	in	in	ADP
admet-470	141	13	silico	silico	NOUN
admet-470	141	14	adme	adme	NOUN
admet-470	141	15	in	in	ADP
admet-470	141	16	drug	drug	NOUN
admet-470	141	17	design	design	NOUN
admet-470	141	18	doi	doi	NOUN
admet-470	141	19	:	:	PUNCT
admet-470	141	20	10.5599	10.5599	NUM
admet-470	141	21	/	/	SYM
admet-470	141	22	admet.6.1.470	admet.6.1.470	NOUN
admet-470	141	23	25	25	NUM
admet-470	141	24	table	table	NOUN
admet-470	141	25	5	5	NUM
admet-470	141	26	.	.	PUNCT
admet-470	141	27	threshold	threshold	NOUN
admet-470	141	28	px	px	PROPN
admet-470	141	29	based	base	VERB
admet-470	141	30	on	on	ADP
admet-470	141	31	a	a	DET
admet-470	141	32	daily	daily	ADJ
admet-470	141	33	dose	dose	NOUN
admet-470	141	34	of	of	ADP
admet-470	141	35	100	100	NUM
admet-470	141	36	mg	mg	PROPN
admet-470	141	37	(	(	PUNCT
admet-470	141	38	1.4	1.4	NUM
admet-470	141	39	mg	mg	PROPN
admet-470	141	40	/	/	SYM
admet-470	141	41	kg	kg	PROPN
admet-470	141	42	)	)	PUNCT
admet-470	141	43	,	,	PUNCT
admet-470	141	44	given	give	VERB
admet-470	141	45	as	as	ADP
admet-470	141	46	1	1	NUM
admet-470	141	47	-	-	SYM
admet-470	141	48	6	6	NUM
admet-470	141	49	doses	dose	NOUN
admet-470	141	50	per	per	ADP
admet-470	141	51	day	day	NOUN
admet-470	141	52	,	,	PUNCT
admet-470	141	53	for	for	ADP
admet-470	141	54	21	21	NUM
admet-470	141	55	known	know	VERB
admet-470	141	56	drugs[9	drugs[9	PROPN
admet-470	141	57	]	]	PUNCT
admet-470	141	58	,	,	PUNCT
admet-470	141	59	derived	derive	VERB
admet-470	141	60	from	from	ADP
admet-470	141	61	in	in	ADP
admet-470	141	62	silico	silico	NOUN
admet-470	141	63	data	datum	NOUN
admet-470	141	64	(	(	PUNCT
admet-470	141	65	as	as	ADP
admet-470	141	66	above	above	ADJ
admet-470	141	67	)	)	PUNCT
admet-470	141	68	,	,	PUNCT
admet-470	141	69	in	in	ADP
admet-470	141	70	vitro	vitro	X
admet-470	141	71	data	datum	NOUN
admet-470	141	72	[	[	X
admet-470	141	73	9	9	NUM
admet-470	141	74	,	,	PUNCT
admet-470	141	75	10	10	NUM
admet-470	141	76	,	,	PUNCT
admet-470	141	77	14	14	NUM
admet-470	141	78	]	]	PUNCT
admet-470	141	79	,	,	PUNCT
admet-470	141	80	and	and	CCONJ
admet-470	141	81	actual	actual	ADJ
admet-470	141	82	human	human	NOUN
admet-470	141	83	in	in	ADP
admet-470	141	84	vivo	vivo	ADJ
admet-470	141	85	data	datum	NOUN
admet-470	141	86	[	[	X
admet-470	141	87	9	9	NUM
admet-470	141	88	]	]	PUNCT
admet-470	141	89	drug	drug	NOUN
admet-470	141	90	name	name	NOUN
admet-470	141	91	threshold	threshold	NOUN
admet-470	141	92	px	px	NOUN
admet-470	141	93	from	from	ADP
admet-470	141	94	in	in	ADP
admet-470	141	95	silicoa	silicoa	PROPN
admet-470	141	96	threshold	threshold	NOUN
admet-470	141	97	px	px	NOUN
admet-470	141	98	from	from	ADP
admet-470	141	99	in	in	ADP
admet-470	141	100	vitrob	vitrob	ADJ
admet-470	141	101	threshold	threshold	NOUN
admet-470	141	102	px	px	NOUN
admet-470	141	103	from	from	ADP
admet-470	141	104	in	in	ADP
admet-470	141	105	vivoc	vivoc	NOUN
admet-470	141	106	acebutolol	acebutolol	NOUN
admet-470	141	107	8.9	8.9	NUM
admet-470	141	108	6.9d	6.9d	NUM
admet-470	141	109	7.8	7.8	NUM
admet-470	141	110	atenolol	atenolol	PROPN
admet-470	141	111	8.2	8.2	NUM
admet-470	141	112	7.8e	7.8e	NUM
admet-470	141	113	,	,	PUNCT
admet-470	141	114	f	f	PROPN
admet-470	141	115	6.5	6.5	NUM
admet-470	141	116	betaxolol	betaxolol	NOUN
admet-470	141	117	8.2	8.2	NUM
admet-470	141	118	7.6e	7.6e	NUM
admet-470	141	119	6.4	6.4	NUM
admet-470	141	120	bisoprolol	bisoprolol	NOUN
admet-470	141	121	10.6	10.6	NUM
admet-470	141	122	7.6e	7.6e	NUM
admet-470	141	123	6.6	6.6	NUM
admet-470	141	124	carvedilol	carvedilol	NOUN
admet-470	141	125	8.9	8.9	NUM
admet-470	141	126	9.7d	9.7d	NUM
admet-470	141	127	9.3	9.3	NUM
admet-470	141	128	cimetidine	cimetidine	NOUN
admet-470	141	129	8.1	8.1	NUM
admet-470	141	130	6.8d	6.8d	NUM
admet-470	141	131	,	,	PUNCT
admet-470	141	132	f	f	PROPN
admet-470	141	133	7.1	7.1	NUM
admet-470	141	134	cyclosporin	cyclosporin	NOUN
admet-470	141	135	11.2	11.2	NUM
admet-470	141	136	nvg	nvg	PROPN
admet-470	141	137	8.9	8.9	NUM
admet-470	141	138	desloratidine	desloratidine	NOUN
admet-470	141	139	9.0	9.0	NUM
admet-470	141	140	7.5d	7.5d	NUM
admet-470	141	141	,	,	PUNCT
admet-470	141	142	h	h	PROPN
admet-470	141	143	nvg	nvg	PROPN
admet-470	141	144	diazepam	diazepam	VERB
admet-470	141	145	9.7	9.7	NUM
admet-470	141	146	6.9d	6.9d	NUM
admet-470	141	147	6.8	6.8	NUM
admet-470	141	148	diclofenac	diclofenac	NOUN
admet-470	141	149	12.4	12.4	NUM
admet-470	141	150	8.9i	8.9i	NUM
admet-470	141	151	,	,	PUNCT
admet-470	141	152	j	j	PROPN
admet-470	141	153	16.0	16.0	NUM
admet-470	141	154	famotidine	famotidine	NOUN
admet-470	141	155	8.3	8.3	NUM
admet-470	141	156	7.8d	7.8d	NOUN
admet-470	141	157	,	,	PUNCT
admet-470	141	158	f	f	PROPN
admet-470	141	159	7.4	7.4	NUM
admet-470	141	160	indomethacin	indomethacin	VERB
admet-470	141	161	9.0	9.0	NUM
admet-470	141	162	9.3e	9.3e	NOUN
admet-470	141	163	,	,	PUNCT
admet-470	141	164	f	f	PROPN
admet-470	141	165	9.5	9.5	NUM
admet-470	141	166	irbesartan	irbesartan	PROPN
admet-470	141	167	9.8	9.8	NUM
admet-470	141	168	8.8e	8.8e	NUM
admet-470	141	169	8.8	8.8	NUM
admet-470	141	170	metoprolol	metoprolol	NOUN
admet-470	141	171	7.8	7.8	NUM
admet-470	141	172	6.6e	6.6e	NUM
admet-470	141	173	7.9	7.9	NUM
admet-470	141	174	nadolol	nadolol	NOUN
admet-470	141	175	8.4	8.4	NUM
admet-470	141	176	7.4d	7.4d	NOUN
admet-470	141	177	,	,	PUNCT
admet-470	141	178	f	f	PROPN
admet-470	141	179	6.7	6.7	NUM
admet-470	141	180	nifedipine	nifedipine	NOUN
admet-470	141	181	8.8	8.8	NUM
admet-470	141	182	9.0d	9.0d	NOUN
admet-470	141	183	8.8	8.8	NUM
admet-470	141	184	pirenzepine	pirenzepine	NOUN
admet-470	141	185	9.6	9.6	NUM
admet-470	141	186	8.0e	8.0e	NUM
admet-470	141	187	7.2	7.2	NUM
admet-470	141	188	prazosin	prazosin	NOUN
admet-470	141	189	8.3	8.3	NUM
admet-470	141	190	7.4d	7.4d	NOUN
admet-470	141	191	7.8	7.8	NUM
admet-470	141	192	propranolol	propranolol	NOUN
admet-470	141	193	8.0	8.0	NUM
admet-470	141	194	7.7e	7.7e	NUM
admet-470	141	195	8.4	8.4	NUM
admet-470	141	196	ranitidine	ranitidine	NOUN
admet-470	141	197	8.7	8.7	NUM
admet-470	141	198	7.3e	7.3e	NUM
admet-470	141	199	7.7	7.7	NUM
admet-470	141	200	ritonavir	ritonavir	PROPN
admet-470	141	201	11.6	11.6	NUM
admet-470	141	202	8.6k	8.6k	PROPN
admet-470	141	203	8.6	8.6	NUM
admet-470	141	204	a	a	DET
admet-470	141	205	threshold	threshold	NOUN
admet-470	141	206	px	px	PROPN
admet-470	141	207	calculated	calculate	VERB
admet-470	141	208	from	from	ADP
admet-470	141	209	in	in	ADP
admet-470	141	210	silico	silico	NOUN
admet-470	141	211	values	value	NOUN
admet-470	141	212	as	as	ADP
admet-470	141	213	in	in	ADP
admet-470	141	214	table	table	NOUN
admet-470	141	215	4	4	NUM
admet-470	141	216	;	;	PUNCT
admet-470	141	217	b	b	X
admet-470	141	218	threshold	threshold	NOUN
admet-470	141	219	px	px	PROPN
admet-470	141	220	calculated	calculate	VERB
admet-470	141	221	from	from	ADP
admet-470	141	222	in	in	ADP
admet-470	141	223	vitro	vitro	X
admet-470	141	224	values	value	NOUN
admet-470	141	225	using	use	VERB
admet-470	141	226	the	the	DET
admet-470	141	227	same	same	ADJ
admet-470	141	228	procedure	procedure	NOUN
admet-470	141	229	as	as	ADP
admet-470	141	230	in	in	ADP
admet-470	141	231	table	table	NOUN
admet-470	141	232	4	4	NUM
admet-470	141	233	(	(	PUNCT
admet-470	141	234	clinthh	clinthh	ADJ
admet-470	141	235	and	and	CCONJ
admet-470	141	236	fu	fu	ADJ
admet-470	141	237	values	value	NOUN
admet-470	141	238	from	from	ADP
admet-470	141	239	ref	ref	NOUN
admet-470	141	240	[	[	X
admet-470	141	241	10	10	NUM
admet-470	141	242	]	]	PUNCT
admet-470	141	243	,	,	PUNCT
admet-470	141	244	papp	papp	NOUN
admet-470	141	245	values	value	NOUN
admet-470	141	246	from	from	ADP
admet-470	141	247	[	[	X
admet-470	141	248	9	9	NUM
admet-470	141	249	]	]	PUNCT
admet-470	141	250	and	and	CCONJ
admet-470	141	251	[	[	X
admet-470	141	252	14	14	NUM
admet-470	141	253	]	]	PUNCT
admet-470	141	254	as	as	SCONJ
admet-470	141	255	specified	specify	VERB
admet-470	141	256	,	,	PUNCT
admet-470	141	257	and	and	CCONJ
admet-470	141	258	in	in	ADP
admet-470	141	259	-	-	PUNCT
admet-470	141	260	house	house	NOUN
admet-470	141	261	values	value	NOUN
admet-470	141	262	for	for	ADP
admet-470	141	263	fuinc	fuinc	NOUN
admet-470	141	264	;	;	PUNCT
admet-470	141	265	c	c	NOUN
admet-470	141	266	threshold	threshold	NOUN
admet-470	141	267	px	px	PROPN
admet-470	141	268	calculated	calculate	VERB
admet-470	141	269	from	from	ADP
admet-470	141	270	in	in	ADP
admet-470	141	271	vivo	vivo	ADJ
admet-470	141	272	values	value	NOUN
admet-470	141	273	[	[	X
admet-470	141	274	9	9	NUM
admet-470	141	275	]	]	PUNCT
admet-470	141	276	using	use	VERB
admet-470	141	277	the	the	DET
admet-470	141	278	same	same	ADJ
admet-470	141	279	procedure	procedure	NOUN
admet-470	141	280	as	as	ADP
admet-470	141	281	in	in	ADP
admet-470	141	282	table	table	NOUN
admet-470	141	283	4	4	NUM
admet-470	141	284	;	;	PUNCT
admet-470	141	285	d	d	X
admet-470	141	286	papp	papp	NOUN
admet-470	141	287	value	value	NOUN
admet-470	141	288	from	from	ADP
admet-470	141	289	ref	ref	NOUN
admet-470	141	290	[	[	X
admet-470	141	291	9	9	NUM
admet-470	141	292	]	]	PUNCT
admet-470	141	293	;	;	PUNCT
admet-470	141	294	e	e	X
admet-470	141	295	papp	papp	NOUN
admet-470	141	296	value	value	NOUN
admet-470	141	297	from	from	ADP
admet-470	141	298	ref	ref	NOUN
admet-470	141	299	[	[	X
admet-470	141	300	14	14	NUM
admet-470	141	301	]	]	X
admet-470	141	302	;	;	PUNCT
admet-470	141	303	f	f	PROPN
admet-470	141	304	fuinc	fuinc	PROPN
admet-470	141	305	value	value	NOUN
admet-470	141	306	from	from	ADP
admet-470	141	307	in	in	ADP
admet-470	141	308	-	-	PUNCT
admet-470	141	309	house	house	NOUN
admet-470	141	310	in	in	ADP
admet-470	141	311	silico	silico	NOUN
admet-470	141	312	model	model	NOUN
admet-470	141	313	;	;	PUNCT
admet-470	141	314	g	g	PROPN
admet-470	141	315	no	no	DET
admet-470	141	316	value	value	NOUN
admet-470	141	317	(	(	PUNCT
admet-470	141	318	not	not	PART
admet-470	141	319	enough	enough	ADJ
admet-470	141	320	experimental	experimental	ADJ
admet-470	141	321	data	datum	NOUN
admet-470	141	322	available	available	ADJ
admet-470	141	323	for	for	ADP
admet-470	141	324	calculation	calculation	NOUN
admet-470	141	325	)	)	PUNCT
admet-470	141	326	;	;	PUNCT
admet-470	141	327	h	h	NOUN
admet-470	141	328	in	in	ADP
admet-470	141	329	-	-	PUNCT
admet-470	141	330	house	house	NOUN
admet-470	141	331	value	value	NOUN
admet-470	141	332	for	for	ADP
admet-470	141	333	clinthh	clinthh	ADJ
admet-470	141	334	;	;	PUNCT
admet-470	141	335	i	i	PRON
admet-470	141	336	fu	fu	NOUN
admet-470	141	337	value	value	NOUN
admet-470	141	338	from	from	ADP
admet-470	141	339	ref	ref	NOUN
admet-470	141	340	[	[	X
admet-470	141	341	17	17	NUM
admet-470	141	342	]	]	X
admet-470	141	343	;	;	PUNCT
admet-470	141	344	j	j	PROPN
admet-470	141	345	papp	papp	NOUN
admet-470	141	346	from	from	ADP
admet-470	141	347	in	in	ADP
admet-470	141	348	-	-	PUNCT
admet-470	141	349	house	house	NOUN
admet-470	141	350	in	in	ADP
admet-470	141	351	silico	silico	NOUN
admet-470	141	352	model	model	NOUN
admet-470	141	353	;	;	PUNCT
admet-470	141	354	k	k	PROPN
admet-470	141	355	in	in	ADP
admet-470	141	356	-	-	PUNCT
admet-470	141	357	house	house	NOUN
admet-470	141	358	value	value	NOUN
admet-470	141	359	for	for	ADP
admet-470	141	360	papp	papp	NOUN
admet-470	141	361	.	.	PUNCT
admet-470	142	1	most	most	ADJ
admet-470	142	2	threshold	threshold	NOUN
admet-470	142	3	px	px	PROPN
admet-470	142	4	values	value	NOUN
admet-470	142	5	can	can	AUX
admet-470	142	6	be	be	AUX
admet-470	142	7	found	find	VERB
admet-470	142	8	within	within	ADP
admet-470	142	9	the	the	DET
admet-470	142	10	range	range	NOUN
admet-470	142	11	of	of	ADP
admet-470	142	12	7	7	NUM
admet-470	142	13	-	-	SYM
admet-470	142	14	9	9	NUM
admet-470	142	15	,	,	PUNCT
admet-470	142	16	with	with	ADP
admet-470	142	17	a	a	DET
admet-470	142	18	couple	couple	NOUN
admet-470	142	19	of	of	ADP
admet-470	142	20	values	value	NOUN
admet-470	142	21	,	,	PUNCT
admet-470	142	22	especially	especially	ADV
admet-470	142	23	in	in	ADP
admet-470	142	24	vivo	vivo	NOUN
admet-470	142	25	derived	derive	VERB
admet-470	142	26	,	,	PUNCT
admet-470	142	27	below	below	ADP
admet-470	142	28	7	7	NUM
admet-470	142	29	and	and	CCONJ
admet-470	142	30	others	other	NOUN
admet-470	142	31	,	,	PUNCT
admet-470	142	32	most	most	ADV
admet-470	142	33	often	often	ADV
admet-470	142	34	in	in	ADP
admet-470	142	35	silico	silico	NOUN
admet-470	142	36	derived	derive	VERB
admet-470	142	37	,	,	PUNCT
admet-470	142	38	above	above	ADP
admet-470	142	39	9	9	NUM
admet-470	142	40	.	.	PUNCT
admet-470	143	1	only	only	ADV
admet-470	143	2	one	one	NUM
admet-470	143	3	of	of	ADP
admet-470	143	4	the	the	DET
admet-470	143	5	compounds	compound	NOUN
admet-470	143	6	for	for	ADP
admet-470	143	7	which	which	PRON
admet-470	143	8	human	human	NOUN
admet-470	143	9	in	in	ADP
admet-470	143	10	vivo	vivo	NOUN
admet-470	143	11	pk	pk	NOUN
admet-470	143	12	data	datum	NOUN
admet-470	143	13	was	be	AUX
admet-470	143	14	available	available	ADJ
admet-470	143	15	showed	show	VERB
admet-470	143	16	an	an	DET
admet-470	143	17	in	in	ADP
admet-470	143	18	vivo	vivo	ADJ
admet-470	143	19	derived	derive	VERB
admet-470	143	20	threshold	threshold	NOUN
admet-470	143	21	px	px	ADP
admet-470	143	22	values	value	NOUN
admet-470	143	23	above	above	ADP
admet-470	143	24	10	10	NUM
admet-470	143	25	,	,	PUNCT
admet-470	143	26	whereas	whereas	SCONJ
admet-470	143	27	all	all	PRON
admet-470	143	28	in	in	ADP
admet-470	143	29	vitro	vitro	X
admet-470	143	30	derived	derive	VERB
admet-470	143	31	threshold	threshold	NOUN
admet-470	143	32	px	px	PROPN
admet-470	143	33	values	value	NOUN
admet-470	143	34	were	be	AUX
admet-470	143	35	actually	actually	ADV
admet-470	143	36	below	below	ADP
admet-470	143	37	10	10	NUM
admet-470	143	38	.	.	PUNCT
admet-470	144	1	the	the	DET
admet-470	144	2	one	one	NUM
admet-470	144	3	compound	compound	NOUN
admet-470	144	4	with	with	ADP
admet-470	144	5	a	a	DET
admet-470	144	6	higher	high	ADJ
admet-470	144	7	in	in	ADP
admet-470	144	8	vivo	vivo	ADJ
admet-470	144	9	data	datum	NOUN
admet-470	144	10	derived	derive	VERB
admet-470	144	11	value	value	NOUN
admet-470	144	12	,	,	PUNCT
admet-470	144	13	diclofenac	diclofenac	NOUN
admet-470	144	14	,	,	PUNCT
admet-470	144	15	was	be	AUX
admet-470	144	16	earlier	early	ADV
admet-470	144	17	recognized	recognize	VERB
admet-470	144	18	as	as	ADP
admet-470	144	19	not	not	PART
admet-470	144	20	being	be	AUX
admet-470	144	21	properly	properly	ADV
admet-470	144	22	described	describe	VERB
admet-470	144	23	by	by	ADP
admet-470	144	24	the	the	DET
admet-470	144	25	one	one	NUM
admet-470	144	26	compartment	compartment	NOUN
admet-470	144	27	pk	pk	NOUN
admet-470	144	28	model	model	NOUN
admet-470	144	29	employed	employ	VERB
admet-470	144	30	here	here	ADV
admet-470	144	31	[	[	X
admet-470	144	32	9	9	NUM
admet-470	144	33	]	]	PUNCT
admet-470	144	34	.	.	PUNCT
admet-470	145	1	for	for	ADP
admet-470	145	2	about	about	ADV
admet-470	145	3	a	a	DET
admet-470	145	4	third	third	NOUN
admet-470	145	5	of	of	ADP
admet-470	145	6	the	the	DET
admet-470	145	7	compounds	compound	NOUN
admet-470	145	8	all	all	DET
admet-470	145	9	three	three	NUM
admet-470	145	10	values	value	NOUN
admet-470	145	11	are	be	AUX
admet-470	145	12	very	very	ADV
admet-470	145	13	close	close	ADJ
admet-470	145	14	within	within	ADP
admet-470	145	15	about	about	ADV
admet-470	145	16	one	one	NUM
admet-470	145	17	log	log	NOUN
admet-470	145	18	unit	unit	NOUN
admet-470	145	19	,	,	PUNCT
admet-470	145	20	e.g.	e.g.	ADV
admet-470	145	21	,	,	PUNCT
admet-470	145	22	carvedilol	carvedilol	NOUN
admet-470	145	23	or	or	CCONJ
admet-470	145	24	nitrendipine	nitrendipine	ADJ
admet-470	145	25	.	.	PUNCT
admet-470	146	1	other	other	ADJ
admet-470	146	2	compounds	compound	NOUN
admet-470	146	3	have	have	VERB
admet-470	146	4	a	a	DET
admet-470	146	5	somewhat	somewhat	ADV
admet-470	146	6	higher	high	ADJ
admet-470	146	7	spread	spread	NOUN
admet-470	146	8	,	,	PUNCT
admet-470	146	9	most	most	ADV
admet-470	146	10	often	often	ADV
admet-470	146	11	the	the	DET
admet-470	146	12	in	in	ADV
admet-470	146	13	vitro	vitro	X
admet-470	146	14	value	value	NOUN
admet-470	146	15	closer	close	ADV
admet-470	146	16	to	to	ADP
admet-470	146	17	the	the	DET
admet-470	146	18	in	in	ADP
admet-470	146	19	vivo	vivo	ADJ
admet-470	146	20	derived	derive	VERB
admet-470	146	21	value	value	NOUN
admet-470	146	22	,	,	PUNCT
admet-470	146	23	e.g.	e.g.	ADV
admet-470	146	24	,	,	PUNCT
admet-470	146	25	acebutolol	acebutolol	NOUN
admet-470	146	26	or	or	CCONJ
admet-470	146	27	betaxolol	betaxolol	NOUN
admet-470	146	28	.	.	PUNCT
admet-470	147	1	for	for	ADP
admet-470	147	2	a	a	DET
admet-470	147	3	few	few	ADJ
admet-470	147	4	compounds	compound	NOUN
admet-470	147	5	the	the	DET
admet-470	147	6	in	in	ADP
admet-470	147	7	silico	silico	NOUN
admet-470	147	8	derived	derive	VERB
admet-470	147	9	value	value	NOUN
admet-470	147	10	is	be	AUX
admet-470	147	11	clearly	clearly	ADV
admet-470	147	12	differing	differ	VERB
admet-470	147	13	from	from	ADP
admet-470	147	14	the	the	DET
admet-470	147	15	other	other	ADJ
admet-470	147	16	two	two	NUM
admet-470	147	17	,	,	PUNCT
admet-470	147	18	e.g.	e.g.	ADV
admet-470	147	19	,	,	PUNCT
admet-470	147	20	bisoprolol	bisoprolol	NOUN
admet-470	147	21	,	,	PUNCT
admet-470	147	22	diazepam	diazepam	NOUN
admet-470	147	23	and	and	CCONJ
admet-470	147	24	ritonavir	ritonavir	NOUN
admet-470	147	25	.	.	PUNCT
admet-470	148	1	to	to	PART
admet-470	148	2	better	well	ADV
admet-470	148	3	understand	understand	VERB
admet-470	148	4	why	why	SCONJ
admet-470	148	5	we	we	PRON
admet-470	148	6	find	find	VERB
admet-470	148	7	the	the	DET
admet-470	148	8	in	in	ADP
admet-470	148	9	silico	silico	NOUN
admet-470	148	10	predictions	prediction	NOUN
admet-470	148	11	differ	differ	VERB
admet-470	148	12	,	,	PUNCT
admet-470	148	13	we	we	PRON
admet-470	148	14	investigated	investigate	VERB
admet-470	148	15	how	how	SCONJ
admet-470	148	16	well	well	ADV
admet-470	148	17	the	the	PRON
admet-470	148	18	in	in	ADP
admet-470	148	19	silico	silico	NOUN
admet-470	148	20	and	and	CCONJ
admet-470	148	21	in	in	ADP
admet-470	148	22	vitro	vitro	X
admet-470	148	23	data	datum	NOUN
admet-470	148	24	can	can	AUX
admet-470	148	25	predict	predict	VERB
admet-470	148	26	human	human	ADJ
admet-470	148	27	in	in	ADP
admet-470	148	28	vivo	vivo	NOUN
admet-470	148	29	properties	property	NOUN
admet-470	148	30	(	(	PUNCT
admet-470	148	31	see	see	VERB
admet-470	148	32	figures	figure	NOUN
admet-470	148	33	2	2	NUM
admet-470	148	34	-	-	SYM
admet-470	148	35	4	4	NUM
admet-470	148	36	)	)	PUNCT
admet-470	148	37	.	.	PUNCT
admet-470	149	1	note	note	VERB
admet-470	149	2	that	that	SCONJ
admet-470	149	3	cyclosporine	cyclosporine	NOUN
admet-470	149	4	and	and	CCONJ
admet-470	149	5	desloratidine	desloratidine	NOUN
admet-470	149	6	were	be	AUX
admet-470	149	7	excluded	exclude	VERB
admet-470	149	8	from	from	ADP
admet-470	149	9	this	this	DET
admet-470	149	10	analysis	analysis	NOUN
admet-470	149	11	,	,	PUNCT
admet-470	149	12	since	since	SCONJ
admet-470	149	13	there	there	PRON
admet-470	149	14	was	be	VERB
admet-470	149	15	not	not	PART
admet-470	149	16	enough	enough	ADJ
admet-470	149	17	in	in	ADP
admet-470	149	18	vitro	vitro	X
admet-470	149	19	data	datum	NOUN
admet-470	149	20	for	for	ADP
admet-470	149	21	the	the	DET
admet-470	149	22	former	former	ADJ
admet-470	149	23	and	and	CCONJ
admet-470	149	24	no	no	ADV
admet-470	149	25	in	in	ADP
admet-470	149	26	vivo	vivo	ADJ
admet-470	149	27	data	datum	NOUN
admet-470	149	28	for	for	ADP
admet-470	149	29	the	the	DET
admet-470	149	30	latter	latter	ADJ
admet-470	149	31	compound	compound	NOUN
admet-470	149	32	.	.	PUNCT
admet-470	150	1	susanne	susanne	PROPN
admet-470	150	2	winiwarter	winiwarter	PROPN
admet-470	150	3	et	et	PROPN
admet-470	150	4	al	al	PROPN
admet-470	150	5	.	.	PROPN
admet-470	150	6	admet	admet	PROPN
admet-470	150	7	&	&	CCONJ
admet-470	150	8	dmpk	dmpk	PROPN
admet-470	150	9	6(1	6(1	NUM
admet-470	150	10	)	)	PUNCT
admet-470	150	11	(	(	PUNCT
admet-470	150	12	2018	2018	NUM
admet-470	150	13	)	)	PUNCT
admet-470	150	14	15	15	NUM
admet-470	150	15	-	-	SYM
admet-470	150	16	33	33	NUM
admet-470	150	17	26	26	NUM
admet-470	150	18	figure	figure	NOUN
admet-470	150	19	1	1	NUM
admet-470	150	20	.	.	PUNCT
admet-470	150	21	comparison	comparison	NOUN
admet-470	150	22	of	of	ADP
admet-470	150	23	threshold	threshold	NOUN
admet-470	150	24	px	px	PROPN
admet-470	150	25	values	value	NOUN
admet-470	150	26	calculated	calculate	VERB
admet-470	150	27	from	from	ADP
admet-470	150	28	purely	purely	ADV
admet-470	150	29	in	in	ADP
admet-470	150	30	silico	silico	NOUN
admet-470	150	31	(	(	PUNCT
admet-470	150	32	open	open	ADJ
admet-470	150	33	circles	circle	NOUN
admet-470	150	34	)	)	PUNCT
admet-470	150	35	,	,	PUNCT
admet-470	150	36	in	in	ADP
admet-470	150	37	vitro	vitro	X
admet-470	150	38	(	(	PUNCT
admet-470	150	39	black	black	ADJ
admet-470	150	40	circles	circle	NOUN
admet-470	150	41	)	)	PUNCT
admet-470	150	42	or	or	CCONJ
admet-470	150	43	in	in	ADP
admet-470	150	44	vivo	vivo	NOUN
admet-470	150	45	(	(	PUNCT
admet-470	150	46	black	black	ADJ
admet-470	150	47	triangles	triangle	NOUN
admet-470	150	48	)	)	PUNCT
admet-470	150	49	data	datum	NOUN
admet-470	150	50	as	as	SCONJ
admet-470	150	51	described	describe	VERB
admet-470	150	52	in	in	ADP
admet-470	150	53	text	text	NOUN
admet-470	150	54	.	.	PUNCT
admet-470	151	1	figure	figure	NOUN
admet-470	151	2	2	2	NUM
admet-470	151	3	shows	show	VERB
admet-470	151	4	that	that	SCONJ
admet-470	151	5	in	in	ADP
admet-470	151	6	silico	silico	NOUN
admet-470	151	7	data	datum	NOUN
admet-470	151	8	tends	tend	VERB
admet-470	151	9	to	to	PART
admet-470	151	10	overpredict	overpredict	VERB
admet-470	151	11	human	human	ADJ
admet-470	151	12	clearance	clearance	NOUN
admet-470	151	13	.	.	PUNCT
admet-470	152	1	the	the	DET
admet-470	152	2	two	two	NUM
admet-470	152	3	compounds	compound	NOUN
admet-470	152	4	on	on	ADP
admet-470	152	5	the	the	DET
admet-470	152	6	left	left	NOUN
admet-470	152	7	,	,	PUNCT
admet-470	152	8	diazepam	diazepam	NOUN
admet-470	152	9	and	and	CCONJ
admet-470	152	10	ritonavir	ritonavir	NOUN
admet-470	152	11	,	,	PUNCT
admet-470	152	12	are	be	AUX
admet-470	152	13	obvious	obvious	ADJ
admet-470	152	14	extremes	extreme	NOUN
admet-470	152	15	,	,	PUNCT
admet-470	152	16	and	and	CCONJ
admet-470	152	17	their	their	PRON
admet-470	152	18	higher	high	ADJ
admet-470	152	19	estimate	estimate	NOUN
admet-470	152	20	of	of	ADP
admet-470	152	21	the	the	DET
admet-470	152	22	threshold	threshold	NOUN
admet-470	152	23	potency	potency	NOUN
admet-470	152	24	value	value	NOUN
admet-470	152	25	are	be	AUX
admet-470	152	26	most	most	ADV
admet-470	152	27	likely	likely	ADV
admet-470	152	28	related	relate	VERB
admet-470	152	29	to	to	ADP
admet-470	152	30	the	the	DET
admet-470	152	31	clearance	clearance	NOUN
admet-470	152	32	misprediction	misprediction	NOUN
admet-470	152	33	.	.	PUNCT
admet-470	153	1	note	note	VERB
admet-470	153	2	that	that	SCONJ
admet-470	153	3	clearance	clearance	NOUN
admet-470	153	4	predictions	prediction	NOUN
admet-470	153	5	from	from	ADP
admet-470	153	6	in	in	ADP
admet-470	153	7	vitro	vitro	X
admet-470	153	8	are	be	AUX
admet-470	153	9	clearly	clearly	ADV
admet-470	153	10	closer	close	ADJ
admet-470	153	11	to	to	ADP
admet-470	153	12	the	the	DET
admet-470	153	13	line	line	NOUN
admet-470	153	14	of	of	ADP
admet-470	153	15	unity	unity	NOUN
admet-470	153	16	.	.	PUNCT
admet-470	154	1	however	however	ADV
admet-470	154	2	,	,	PUNCT
admet-470	154	3	we	we	PRON
admet-470	154	4	find	find	VERB
admet-470	154	5	two	two	NUM
admet-470	154	6	compounds	compound	NOUN
admet-470	154	7	,	,	PUNCT
admet-470	154	8	diclofenac	diclofenac	NOUN
admet-470	154	9	and	and	CCONJ
admet-470	154	10	metoprolol	metoprolol	NOUN
admet-470	154	11	,	,	PUNCT
admet-470	154	12	to	to	PART
admet-470	154	13	be	be	AUX
admet-470	154	14	under	under	ADP
admet-470	154	15	predicted	predict	VERB
admet-470	154	16	by	by	ADP
admet-470	154	17	more	more	ADJ
admet-470	154	18	than	than	ADP
admet-470	154	19	3	3	NUM
admet-470	154	20	-	-	NOUN
admet-470	154	21	fold	fold	ADJ
admet-470	154	22	using	use	VERB
admet-470	154	23	the	the	DET
admet-470	154	24	present	present	ADJ
admet-470	154	25	scaling	scaling	NOUN
admet-470	154	26	approach	approach	NOUN
admet-470	154	27	.	.	PUNCT
admet-470	155	1	this	this	PRON
admet-470	155	2	can	can	AUX
admet-470	155	3	also	also	ADV
admet-470	155	4	be	be	AUX
admet-470	155	5	seen	see	VERB
admet-470	155	6	in	in	ADP
admet-470	155	7	a	a	DET
admet-470	155	8	more	more	ADV
admet-470	155	9	optimistic	optimistic	ADJ
admet-470	155	10	threshold	threshold	NOUN
admet-470	155	11	px	px	NOUN
admet-470	155	12	value	value	NOUN
admet-470	155	13	when	when	SCONJ
admet-470	155	14	compared	compare	VERB
admet-470	155	15	to	to	ADP
admet-470	155	16	in	in	ADP
admet-470	155	17	vivo	vivo	NOUN
admet-470	155	18	(	(	PUNCT
admet-470	155	19	see	see	VERB
admet-470	155	20	figure	figure	NOUN
admet-470	155	21	1	1	NUM
admet-470	155	22	)	)	PUNCT
admet-470	155	23	.	.	PUNCT
admet-470	156	1	overall	overall	ADJ
admet-470	156	2	,	,	PUNCT
admet-470	156	3	about	about	ADV
admet-470	156	4	two	two	NUM
admet-470	156	5	thirds	third	NOUN
admet-470	156	6	of	of	ADP
admet-470	156	7	the	the	DET
admet-470	156	8	compounds	compound	NOUN
admet-470	156	9	have	have	AUX
admet-470	156	10	in	in	ADP
admet-470	156	11	silico	silico	NOUN
admet-470	156	12	predicted	predict	VERB
admet-470	156	13	clearance	clearance	NOUN
admet-470	156	14	values	value	NOUN
admet-470	156	15	within	within	ADP
admet-470	156	16	3	3	NUM
admet-470	156	17	-	-	NOUN
admet-470	156	18	fold	fold	ADJ
admet-470	156	19	from	from	ADP
admet-470	156	20	the	the	DET
admet-470	156	21	experimental	experimental	ADJ
admet-470	156	22	in	in	ADP
admet-470	156	23	vivo	vivo	ADJ
admet-470	156	24	values	value	NOUN
admet-470	156	25	,	,	PUNCT
admet-470	156	26	and	and	CCONJ
admet-470	156	27	all	all	DET
admet-470	156	28	but	but	SCONJ
admet-470	156	29	two	two	NUM
admet-470	156	30	compounds	compound	NOUN
admet-470	156	31	are	be	AUX
admet-470	156	32	within	within	ADP
admet-470	156	33	3	3	ADJ
admet-470	156	34	-	-	ADJ
admet-470	156	35	fold	fold	ADJ
admet-470	156	36	utilizing	utilizing	NOUN
admet-470	156	37	in	in	ADP
admet-470	156	38	vitro	vitro	ADJ
admet-470	156	39	values	value	NOUN
admet-470	156	40	.	.	PUNCT
admet-470	157	1	figure	figure	NOUN
admet-470	157	2	2	2	NUM
admet-470	157	3	.	.	PUNCT
admet-470	158	1	human	human	ADJ
admet-470	158	2	in	in	ADP
admet-470	158	3	vivo	vivo	ADJ
admet-470	158	4	plasma	plasma	NOUN
admet-470	158	5	clearance	clearance	NOUN
admet-470	158	6	plotted	plot	VERB
admet-470	158	7	against	against	ADP
admet-470	158	8	predicted	predict	VERB
admet-470	158	9	clearance	clearance	NOUN
admet-470	158	10	based	base	VERB
admet-470	158	11	purely	purely	ADV
admet-470	158	12	on	on	ADV
admet-470	158	13	in	in	ADP
admet-470	158	14	silico	silico	NOUN
admet-470	158	15	property	property	NOUN
admet-470	158	16	calculations	calculation	NOUN
admet-470	158	17	(	(	PUNCT
admet-470	158	18	open	open	ADJ
admet-470	158	19	circles	circle	NOUN
admet-470	158	20	)	)	PUNCT
admet-470	158	21	and	and	CCONJ
admet-470	158	22	on	on	ADP
admet-470	158	23	in	in	ADP
admet-470	158	24	vitro	vitro	X
admet-470	158	25	data	datum	NOUN
admet-470	158	26	for	for	ADP
admet-470	158	27	human	human	ADJ
admet-470	158	28	hepatocyte	hepatocyte	PROPN
admet-470	158	29	clint	clint	NOUN
admet-470	158	30	,	,	PUNCT
admet-470	158	31	human	human	ADJ
admet-470	158	32	protein	protein	NOUN
admet-470	158	33	binding	bind	VERB
admet-470	158	34	and	and	CCONJ
admet-470	158	35	hepatocyte	hepatocyte	NOUN
admet-470	158	36	incubation	incubation	NOUN
admet-470	158	37	binding	bind	VERB
admet-470	158	38	(	(	PUNCT
admet-470	158	39	black	black	ADJ
admet-470	158	40	circles	circle	NOUN
admet-470	158	41	)	)	PUNCT
admet-470	158	42	.	.	PUNCT
admet-470	159	1	full	full	ADJ
admet-470	159	2	line	line	NOUN
admet-470	159	3	indicates	indicate	VERB
admet-470	159	4	unity	unity	NOUN
admet-470	159	5	,	,	PUNCT
admet-470	159	6	dashed	dash	VERB
admet-470	159	7	lines	line	NOUN
admet-470	159	8	3	3	ADJ
admet-470	159	9	-	-	ADJ
admet-470	159	10	fold	fold	ADJ
admet-470	159	11	limits	limit	NOUN
admet-470	159	12	.	.	PUNCT
admet-470	160	1	admet	admet	PROPN
admet-470	160	2	&	&	CCONJ
admet-470	160	3	dmpk	dmpk	PROPN
admet-470	160	4	6(1	6(1	NUM
admet-470	160	5	)	)	PUNCT
admet-470	160	6	(	(	PUNCT
admet-470	160	7	2018	2018	NUM
admet-470	160	8	)	)	PUNCT
admet-470	160	9	15	15	NUM
admet-470	160	10	-	-	SYM
admet-470	160	11	33	33	NUM
admet-470	160	12	in	in	ADP
admet-470	160	13	silico	silico	NOUN
admet-470	160	14	adme	adme	NOUN
admet-470	160	15	in	in	ADP
admet-470	160	16	drug	drug	NOUN
admet-470	160	17	design	design	NOUN
admet-470	160	18	doi	doi	NOUN
admet-470	160	19	:	:	PUNCT
admet-470	160	20	10.5599	10.5599	NUM
admet-470	160	21	/	/	SYM
admet-470	160	22	admet.6.1.470	admet.6.1.470	X
admet-470	160	23	27	27	NUM
admet-470	160	24	figure	figure	NOUN
admet-470	160	25	3	3	NUM
admet-470	160	26	.	.	PUNCT
admet-470	160	27	human	human	ADJ
admet-470	160	28	in	in	ADP
admet-470	160	29	vivo	vivo	ADJ
admet-470	160	30	plasma	plasma	NOUN
admet-470	160	31	half	half	ADJ
admet-470	160	32	-	-	PUNCT
admet-470	160	33	life	life	NOUN
admet-470	160	34	plotted	plot	VERB
admet-470	160	35	against	against	ADP
admet-470	160	36	predicted	predict	VERB
admet-470	160	37	half	half	ADJ
admet-470	160	38	-	-	PUNCT
admet-470	160	39	life	life	NOUN
admet-470	160	40	based	base	VERB
admet-470	160	41	upon	upon	SCONJ
admet-470	160	42	in	in	ADP
admet-470	160	43	silico	silico	NOUN
admet-470	160	44	volume	volume	NOUN
admet-470	160	45	of	of	ADP
admet-470	160	46	distribution	distribution	NOUN
admet-470	160	47	and	and	CCONJ
admet-470	160	48	clearance	clearance	NOUN
admet-470	160	49	calculated	calculate	VERB
admet-470	160	50	from	from	ADP
admet-470	160	51	in	in	ADP
admet-470	160	52	silico	silico	NOUN
admet-470	160	53	property	property	NOUN
admet-470	160	54	calculations	calculation	NOUN
admet-470	160	55	(	(	PUNCT
admet-470	160	56	open	open	ADJ
admet-470	160	57	circles	circle	NOUN
admet-470	160	58	)	)	PUNCT
admet-470	160	59	or	or	CCONJ
admet-470	160	60	clearance	clearance	NOUN
admet-470	160	61	calculated	calculate	VERB
admet-470	160	62	from	from	ADP
admet-470	160	63	in	in	ADP
admet-470	160	64	vitro	vitro	X
admet-470	160	65	data	datum	NOUN
admet-470	160	66	(	(	PUNCT
admet-470	160	67	black	black	ADJ
admet-470	160	68	circles	circle	NOUN
admet-470	160	69	)	)	PUNCT
admet-470	160	70	.	.	PUNCT
admet-470	161	1	full	full	ADJ
admet-470	161	2	line	line	NOUN
admet-470	161	3	indicates	indicate	VERB
admet-470	161	4	unity	unity	NOUN
admet-470	161	5	,	,	PUNCT
admet-470	161	6	dashed	dash	VERB
admet-470	161	7	lines	line	NOUN
admet-470	161	8	3	3	ADJ
admet-470	161	9	-	-	ADJ
admet-470	161	10	fold	fold	ADJ
admet-470	161	11	limits	limit	NOUN
admet-470	161	12	.	.	PUNCT
admet-470	162	1	also	also	ADV
admet-470	162	2	the	the	DET
admet-470	162	3	underprediction	underprediction	NOUN
admet-470	162	4	of	of	ADP
admet-470	162	5	half	half	ADJ
admet-470	162	6	-	-	PUNCT
admet-470	162	7	life	life	NOUN
admet-470	162	8	from	from	ADP
admet-470	162	9	in	in	ADP
admet-470	162	10	silico	silico	NOUN
admet-470	162	11	data	datum	NOUN
admet-470	162	12	is	be	AUX
admet-470	162	13	mostly	mostly	ADV
admet-470	162	14	due	due	ADJ
admet-470	162	15	to	to	ADP
admet-470	162	16	the	the	DET
admet-470	162	17	clearance	clearance	NOUN
admet-470	162	18	prediction	prediction	NOUN
admet-470	162	19	,	,	PUNCT
admet-470	162	20	while	while	SCONJ
admet-470	162	21	half	half	ADJ
admet-470	162	22	-	-	PUNCT
admet-470	162	23	life	life	NOUN
admet-470	162	24	prediction	prediction	NOUN
admet-470	162	25	from	from	ADP
admet-470	162	26	in	in	ADP
admet-470	162	27	vitro	vitro	NOUN
admet-470	162	28	,	,	PUNCT
admet-470	162	29	using	use	VERB
admet-470	162	30	the	the	DET
admet-470	162	31	same	same	ADJ
admet-470	162	32	in	in	ADP
admet-470	162	33	silico	silico	NOUN
admet-470	162	34	derived	derive	VERB
admet-470	162	35	value	value	NOUN
admet-470	162	36	for	for	ADP
admet-470	162	37	distribution	distribution	NOUN
admet-470	162	38	volume	volume	NOUN
admet-470	162	39	,	,	PUNCT
admet-470	162	40	is	be	AUX
admet-470	162	41	clearly	clearly	ADV
admet-470	162	42	enhanced	enhance	VERB
admet-470	162	43	.	.	PUNCT
admet-470	163	1	human	human	ADJ
admet-470	163	2	fraction	fraction	NOUN
admet-470	163	3	absorbed	absorb	VERB
admet-470	163	4	seems	seem	VERB
admet-470	163	5	to	to	PART
admet-470	163	6	be	be	AUX
admet-470	163	7	the	the	DET
admet-470	163	8	most	most	ADV
admet-470	163	9	difficult	difficult	ADJ
admet-470	163	10	parameter	parameter	NOUN
admet-470	163	11	to	to	PART
admet-470	163	12	predict	predict	VERB
admet-470	163	13	correctly	correctly	ADV
admet-470	163	14	(	(	PUNCT
admet-470	163	15	see	see	VERB
admet-470	163	16	figure	figure	NOUN
admet-470	163	17	4	4	NUM
admet-470	163	18	)	)	PUNCT
admet-470	163	19	.	.	PUNCT
admet-470	164	1	while	while	SCONJ
admet-470	164	2	both	both	PRON
admet-470	164	3	in	in	ADP
admet-470	164	4	silico	silico	NOUN
admet-470	164	5	and	and	CCONJ
admet-470	164	6	in	in	ADP
admet-470	164	7	vitro	vitro	X
admet-470	164	8	predictions	prediction	NOUN
admet-470	164	9	identify	identify	VERB
admet-470	164	10	the	the	DET
admet-470	164	11	two	two	NUM
admet-470	164	12	compounds	compound	NOUN
admet-470	164	13	with	with	ADP
admet-470	164	14	fabs	fab	NOUN
admet-470	164	15	below	below	ADP
admet-470	164	16	0.4	0.4	NUM
admet-470	164	17	,	,	PUNCT
admet-470	164	18	compounds	compound	VERB
admet-470	164	19	with	with	ADP
admet-470	164	20	fabs	fab	NOUN
admet-470	164	21	between	between	ADP
admet-470	164	22	0.4	0.4	NUM
admet-470	164	23	and	and	CCONJ
admet-470	164	24	0.6	0.6	NUM
admet-470	164	25	were	be	AUX
admet-470	164	26	only	only	ADV
admet-470	164	27	recognized	recognize	VERB
admet-470	164	28	in	in	ADP
admet-470	164	29	two	two	NUM
admet-470	164	30	or	or	CCONJ
admet-470	164	31	three	three	NUM
admet-470	164	32	cases	case	NOUN
admet-470	164	33	from	from	ADP
admet-470	164	34	in	in	ADP
admet-470	164	35	silico	silico	NOUN
admet-470	164	36	and	and	CCONJ
admet-470	164	37	in	in	ADP
admet-470	164	38	vitro	vitro	X
admet-470	164	39	data	datum	NOUN
admet-470	164	40	,	,	PUNCT
admet-470	164	41	respectively	respectively	ADV
admet-470	164	42	.	.	PUNCT
admet-470	165	1	however	however	ADV
admet-470	165	2	,	,	PUNCT
admet-470	165	3	this	this	DET
admet-470	165	4	failure	failure	NOUN
admet-470	165	5	is	be	AUX
admet-470	165	6	not	not	PART
admet-470	165	7	necessarily	necessarily	ADV
admet-470	165	8	a	a	DET
admet-470	165	9	concern	concern	NOUN
admet-470	165	10	in	in	ADP
admet-470	165	11	the	the	DET
admet-470	165	12	present	present	ADJ
admet-470	165	13	case	case	NOUN
admet-470	165	14	,	,	PUNCT
admet-470	165	15	since	since	SCONJ
admet-470	165	16	the	the	DET
admet-470	165	17	relationship	relationship	NOUN
admet-470	165	18	between	between	ADP
admet-470	165	19	fabs	fab	NOUN
admet-470	165	20	and	and	CCONJ
admet-470	165	21	plasma	plasma	NOUN
admet-470	165	22	concentrations	concentration	NOUN
admet-470	165	23	is	be	AUX
admet-470	165	24	assumed	assume	VERB
admet-470	165	25	to	to	PART
admet-470	165	26	be	be	AUX
admet-470	165	27	linear	linear	ADJ
admet-470	165	28	and	and	CCONJ
admet-470	165	29	a	a	DET
admet-470	165	30	2	2	NUM
admet-470	165	31	-	-	ADJ
admet-470	165	32	fold	fold	ADJ
admet-470	165	33	change	change	NOUN
admet-470	165	34	in	in	ADP
admet-470	165	35	fraction	fraction	NOUN
admet-470	165	36	absorbed	absorb	VERB
admet-470	165	37	will	will	AUX
admet-470	165	38	lead	lead	VERB
admet-470	165	39	to	to	ADP
admet-470	165	40	a	a	DET
admet-470	165	41	2	2	NUM
admet-470	165	42	-	-	ADJ
admet-470	165	43	fold	fold	ADJ
admet-470	165	44	change	change	NOUN
admet-470	165	45	in	in	ADP
admet-470	165	46	plasma	plasma	NOUN
admet-470	165	47	concentration	concentration	NOUN
admet-470	165	48	and	and	CCONJ
admet-470	165	49	thereby	thereby	ADV
admet-470	165	50	only	only	ADV
admet-470	165	51	to	to	ADP
admet-470	165	52	a	a	DET
admet-470	165	53	0.3	0.3	NUM
admet-470	165	54	log	log	NOUN
admet-470	165	55	units	unit	NOUN
admet-470	165	56	change	change	VERB
admet-470	165	57	for	for	ADP
admet-470	165	58	the	the	DET
admet-470	165	59	threshold	threshold	NOUN
admet-470	165	60	px	px	PROPN
admet-470	165	61	.	.	PROPN
admet-470	166	1	actually	actually	ADV
admet-470	166	2	,	,	PUNCT
admet-470	166	3	page	page	NOUN
admet-470	166	4	[	[	X
admet-470	166	5	10	10	NUM
admet-470	166	6	]	]	PUNCT
admet-470	166	7	suggested	suggest	VERB
admet-470	166	8	,	,	PUNCT
admet-470	166	9	that	that	DET
admet-470	166	10	estimation	estimation	NOUN
admet-470	166	11	of	of	ADP
admet-470	166	12	fabs	fab	NOUN
admet-470	166	13	as	as	ADP
admet-470	166	14	either	either	CCONJ
admet-470	166	15	1	1	NUM
admet-470	166	16	(	(	PUNCT
admet-470	166	17	acids	acid	NOUN
admet-470	166	18	)	)	PUNCT
admet-470	166	19	or	or	CCONJ
admet-470	166	20	0.5	0.5	NUM
admet-470	166	21	(	(	PUNCT
admet-470	166	22	all	all	DET
admet-470	166	23	other	other	ADJ
admet-470	166	24	ion	ion	NOUN
admet-470	166	25	classes	class	NOUN
admet-470	166	26	)	)	PUNCT
admet-470	166	27	is	be	AUX
admet-470	166	28	sufficiently	sufficiently	ADV
admet-470	166	29	accurate	accurate	ADJ
admet-470	166	30	for	for	ADP
admet-470	166	31	early	early	ADJ
admet-470	166	32	d2	d2	PROPN
admet-470	166	33	m	m	PROPN
admet-470	166	34	predictions	prediction	NOUN
admet-470	166	35	.	.	PUNCT
admet-470	167	1	figure	figure	NOUN
admet-470	167	2	4	4	NUM
admet-470	167	3	.	.	PUNCT
admet-470	168	1	human	human	ADJ
admet-470	168	2	fraction	fraction	NOUN
admet-470	168	3	absorbed	absorb	VERB
admet-470	168	4	plotted	plot	VERB
admet-470	168	5	against	against	ADP
admet-470	168	6	predicted	predict	VERB
admet-470	168	7	fraction	fraction	NOUN
admet-470	168	8	absorbed	absorb	VERB
admet-470	168	9	from	from	ADP
admet-470	168	10	in	in	ADP
admet-470	168	11	silico	silico	NOUN
admet-470	168	12	caco	caco	NOUN
admet-470	168	13	permeability	permeability	NOUN
admet-470	168	14	prediction	prediction	NOUN
admet-470	168	15	(	(	PUNCT
admet-470	168	16	black	black	ADJ
admet-470	168	17	circles	circle	NOUN
admet-470	168	18	)	)	PUNCT
admet-470	168	19	or	or	CCONJ
admet-470	168	20	in	in	ADP
admet-470	168	21	vitro	vitro	X
admet-470	168	22	caco	caco	PROPN
admet-470	168	23	permeability	permeability	PROPN
admet-470	168	24	data	datum	NOUN
admet-470	168	25	(	(	PUNCT
admet-470	168	26	grey	grey	PROPN
admet-470	168	27	circles	circle	NOUN
admet-470	168	28	)	)	PUNCT
admet-470	168	29	.	.	PUNCT
admet-470	169	1	full	full	ADJ
admet-470	169	2	line	line	NOUN
admet-470	169	3	indicates	indicate	VERB
admet-470	169	4	unity	unity	NOUN
admet-470	169	5	,	,	PUNCT
admet-470	169	6	dashed	dash	VERB
admet-470	169	7	lines	line	NOUN
admet-470	169	8	3	3	ADJ
admet-470	169	9	-	-	ADJ
admet-470	169	10	fold	fold	ADJ
admet-470	169	11	limits	limit	NOUN
admet-470	169	12	.	.	PUNCT
admet-470	170	1	susanne	susanne	PROPN
admet-470	170	2	winiwarter	winiwarter	PROPN
admet-470	170	3	et	et	PROPN
admet-470	170	4	al	al	PROPN
admet-470	170	5	.	.	PROPN
admet-470	170	6	admet	admet	PROPN
admet-470	170	7	&	&	CCONJ
admet-470	170	8	dmpk	dmpk	PROPN
admet-470	170	9	6(1	6(1	NUM
admet-470	170	10	)	)	PUNCT
admet-470	170	11	(	(	PUNCT
admet-470	170	12	2018	2018	NUM
admet-470	170	13	)	)	PUNCT
admet-470	170	14	15	15	NUM
admet-470	170	15	-	-	SYM
admet-470	170	16	33	33	NUM
admet-470	170	17	28	28	NUM
admet-470	170	18	influence	influence	NOUN
admet-470	170	19	of	of	ADP
admet-470	170	20	basic	basic	ADJ
admet-470	170	21	parameters	parameter	NOUN
admet-470	170	22	–	–	PUNCT
admet-470	170	23	intrinsic	intrinsic	ADJ
admet-470	170	24	clearance	clearance	NOUN
admet-470	170	25	,	,	PUNCT
admet-470	170	26	fraction	fraction	NOUN
admet-470	170	27	unbound	unbound	NOUN
admet-470	170	28	in	in	ADP
admet-470	170	29	the	the	DET
admet-470	170	30	hepatocyte	hepatocyte	NOUN
admet-470	170	31	incubation	incubation	NOUN
admet-470	170	32	,	,	PUNCT
admet-470	170	33	plasma	plasma	NOUN
admet-470	170	34	protein	protein	NOUN
admet-470	170	35	binding	bind	VERB
admet-470	170	36	and	and	CCONJ
admet-470	170	37	volume	volume	NOUN
admet-470	170	38	of	of	ADP
admet-470	170	39	distribution	distribution	NOUN
admet-470	170	40	using	use	VERB
admet-470	170	41	pharmacokinetic	pharmacokinetic	ADJ
admet-470	170	42	equations	equation	NOUN
admet-470	170	43	assuming	assume	VERB
admet-470	170	44	a	a	DET
admet-470	170	45	one	one	NUM
admet-470	170	46	compartment	compartment	NOUN
admet-470	170	47	model	model	NOUN
admet-470	170	48	both	both	CCONJ
admet-470	170	49	dose	dose	NOUN
admet-470	170	50	and	and	CCONJ
admet-470	170	51	fraction	fraction	NOUN
admet-470	170	52	absorbed	absorb	VERB
admet-470	170	53	are	be	AUX
admet-470	170	54	linearly	linearly	ADV
admet-470	170	55	related	relate	VERB
admet-470	170	56	to	to	ADP
admet-470	170	57	the	the	DET
admet-470	170	58	derived	derive	VERB
admet-470	170	59	plasma	plasma	NOUN
admet-470	170	60	concentrations	concentration	NOUN
admet-470	170	61	and	and	CCONJ
admet-470	170	62	it	it	PRON
admet-470	170	63	is	be	AUX
admet-470	170	64	easily	easily	ADV
admet-470	170	65	understood	understand	VERB
admet-470	170	66	how	how	SCONJ
admet-470	170	67	either	either	PRON
admet-470	170	68	of	of	ADP
admet-470	170	69	these	these	DET
admet-470	170	70	parameters	parameter	NOUN
admet-470	170	71	will	will	AUX
admet-470	170	72	influence	influence	VERB
admet-470	170	73	the	the	DET
admet-470	170	74	threshold	threshold	NOUN
admet-470	170	75	pic50	pic50	NOUN
admet-470	170	76	calculation	calculation	NOUN
admet-470	170	77	.	.	PUNCT
admet-470	171	1	the	the	DET
admet-470	171	2	remaining	remain	VERB
admet-470	171	3	four	four	NUM
admet-470	171	4	input	input	NOUN
admet-470	171	5	parameters	parameter	NOUN
admet-470	171	6	,	,	PUNCT
admet-470	171	7	clinthh	clinthh	ADJ
admet-470	171	8	,	,	PUNCT
admet-470	171	9	fuinc	fuinc	PROPN
admet-470	171	10	,	,	PUNCT
admet-470	171	11	fu	fu	NOUN
admet-470	171	12	,	,	PUNCT
admet-470	171	13	and	and	CCONJ
admet-470	171	14	v	v	NOUN
admet-470	171	15	,	,	PUNCT
admet-470	171	16	on	on	ADP
admet-470	171	17	the	the	DET
admet-470	171	18	other	other	ADJ
admet-470	171	19	hand	hand	NOUN
admet-470	171	20	are	be	AUX
admet-470	171	21	more	more	ADV
admet-470	171	22	intricately	intricately	ADV
admet-470	171	23	interlinked	interlink	VERB
admet-470	171	24	,	,	PUNCT
admet-470	171	25	especially	especially	ADV
admet-470	171	26	since	since	SCONJ
admet-470	171	27	the	the	DET
admet-470	171	28	first	first	ADJ
admet-470	171	29	three	three	NUM
admet-470	171	30	also	also	ADV
admet-470	171	31	are	be	AUX
admet-470	171	32	included	include	VERB
admet-470	171	33	in	in	ADP
admet-470	171	34	the	the	DET
admet-470	171	35	scaling	scale	VERB
admet-470	171	36	approach	approach	NOUN
admet-470	171	37	converting	convert	VERB
admet-470	171	38	in	in	ADP
admet-470	171	39	vitro	vitro	X
admet-470	171	40	(	(	PUNCT
admet-470	171	41	in	in	ADP
admet-470	171	42	silico	silico	NOUN
admet-470	171	43	)	)	PUNCT
admet-470	171	44	clint	clint	NOUN
admet-470	171	45	to	to	ADP
admet-470	171	46	in	in	ADP
admet-470	171	47	vivo	vivo	ADJ
admet-470	171	48	clearance	clearance	NOUN
admet-470	171	49	using	use	VERB
admet-470	171	50	the	the	DET
admet-470	171	51	well	well	ADV
admet-470	171	52	-	-	PUNCT
admet-470	171	53	stirred	stir	VERB
admet-470	171	54	liver	liver	NOUN
admet-470	171	55	model	model	NOUN
admet-470	171	56	(	(	PUNCT
admet-470	171	57	equations	equation	NOUN
admet-470	171	58	5	5	NUM
admet-470	171	59	and	and	CCONJ
admet-470	171	60	9	9	NUM
admet-470	171	61	)	)	PUNCT
admet-470	171	62	.	.	PUNCT
admet-470	172	1	in	in	ADP
admet-470	172	2	order	order	NOUN
admet-470	172	3	to	to	PART
admet-470	172	4	better	well	ADV
admet-470	172	5	understand	understand	VERB
admet-470	172	6	how	how	SCONJ
admet-470	172	7	these	these	DET
admet-470	172	8	parameters	parameter	NOUN
admet-470	172	9	influence	influence	VERB
admet-470	172	10	the	the	DET
admet-470	172	11	outcome	outcome	NOUN
admet-470	172	12	,	,	PUNCT
admet-470	172	13	threshold	threshold	VERB
admet-470	172	14	pic50	pic50	ADJ
admet-470	172	15	values	value	NOUN
admet-470	172	16	for	for	ADP
admet-470	172	17	hypothetical	hypothetical	ADJ
admet-470	172	18	compounds	compound	NOUN
admet-470	172	19	with	with	ADP
admet-470	172	20	hepatocyte	hepatocyte	NOUN
admet-470	172	21	clint	clint	NOUN
admet-470	172	22	values	value	NOUN
admet-470	172	23	varying	vary	VERB
admet-470	172	24	from	from	ADP
admet-470	172	25	1	1	NUM
admet-470	172	26	to	to	ADP
admet-470	172	27	200	200	NUM
admet-470	172	28	l	l	NOUN
admet-470	172	29	/	/	SYM
admet-470	172	30	min/106	min/106	NOUN
admet-470	172	31	cells	cell	NOUN
admet-470	172	32	,	,	PUNCT
admet-470	172	33	values	value	NOUN
admet-470	172	34	for	for	ADP
admet-470	172	35	fraction	fraction	NOUN
admet-470	172	36	unbound	unbound	NOUN
admet-470	172	37	in	in	ADP
admet-470	172	38	the	the	DET
admet-470	172	39	incubation	incubation	NOUN
admet-470	172	40	varying	vary	VERB
admet-470	172	41	from	from	ADP
admet-470	172	42	0.01	0.01	NUM
admet-470	172	43	to	to	ADP
admet-470	172	44	0.7	0.7	NUM
admet-470	172	45	,	,	PUNCT
admet-470	172	46	values	value	NOUN
admet-470	172	47	for	for	ADP
admet-470	172	48	protein	protein	NOUN
admet-470	172	49	binding	bind	VERB
admet-470	172	50	(	(	PUNCT
admet-470	172	51	fu	fu	NOUN
admet-470	172	52	)	)	PUNCT
admet-470	172	53	varying	vary	VERB
admet-470	172	54	from	from	ADP
admet-470	172	55	0.001	0.001	NUM
admet-470	172	56	to	to	ADP
admet-470	172	57	0.3	0.3	NUM
admet-470	172	58	,	,	PUNCT
admet-470	172	59	and	and	CCONJ
admet-470	172	60	volume	volume	NOUN
admet-470	172	61	of	of	ADP
admet-470	172	62	distribution	distribution	NOUN
admet-470	172	63	varying	vary	VERB
admet-470	172	64	from	from	ADP
admet-470	172	65	0.2	0.2	NUM
admet-470	172	66	to	to	ADP
admet-470	172	67	3	3	NUM
admet-470	172	68	l	l	NOUN
admet-470	172	69	/	/	SYM
admet-470	172	70	kg	kg	PROPN
admet-470	172	71	were	be	AUX
admet-470	172	72	calculated	calculate	VERB
admet-470	172	73	(	(	PUNCT
admet-470	172	74	see	see	VERB
admet-470	172	75	figure	figure	NOUN
admet-470	172	76	5	5	NUM
admet-470	172	77	)	)	PUNCT
admet-470	172	78	.	.	PUNCT
admet-470	173	1	as	as	SCONJ
admet-470	173	2	expected	expect	VERB
admet-470	173	3	,	,	PUNCT
admet-470	173	4	lower	low	ADJ
admet-470	173	5	intrinsic	intrinsic	ADJ
admet-470	173	6	clearance	clearance	NOUN
admet-470	173	7	as	as	SCONJ
admet-470	173	8	measured	measure	VERB
admet-470	173	9	in	in	ADP
admet-470	173	10	hepatocytes	hepatocyte	NOUN
admet-470	173	11	leads	lead	VERB
admet-470	173	12	to	to	ADP
admet-470	173	13	a	a	DET
admet-470	173	14	lower	low	ADJ
admet-470	173	15	threshold	threshold	NOUN
admet-470	173	16	pic50	pic50	NOUN
admet-470	173	17	estimate	estimate	NOUN
admet-470	173	18	.	.	PUNCT
admet-470	174	1	however	however	ADV
admet-470	174	2	,	,	PUNCT
admet-470	174	3	the	the	DET
admet-470	174	4	sensitivity	sensitivity	NOUN
admet-470	174	5	of	of	ADP
admet-470	174	6	this	this	DET
admet-470	174	7	correlation	correlation	NOUN
admet-470	174	8	varies	vary	VERB
admet-470	174	9	both	both	CCONJ
admet-470	174	10	with	with	ADP
admet-470	174	11	the	the	DET
admet-470	174	12	fuinc	fuinc	PROPN
admet-470	174	13	/	/	SYM
admet-470	174	14	fub	fub	PROPN
admet-470	174	15	ratio	ratio	NOUN
admet-470	174	16	and	and	CCONJ
admet-470	174	17	the	the	DET
admet-470	174	18	volume	volume	NOUN
admet-470	174	19	of	of	ADP
admet-470	174	20	distribution	distribution	NOUN
admet-470	174	21	:	:	PUNCT
admet-470	174	22	lower	low	ADJ
admet-470	174	23	volume	volume	NOUN
admet-470	174	24	of	of	ADP
admet-470	174	25	distribution	distribution	NOUN
admet-470	174	26	leads	lead	VERB
admet-470	174	27	to	to	ADP
admet-470	174	28	higher	high	ADJ
admet-470	174	29	sensitivity	sensitivity	NOUN
admet-470	174	30	towards	towards	ADP
admet-470	174	31	intrinsic	intrinsic	ADJ
admet-470	174	32	clearance	clearance	NOUN
admet-470	174	33	.	.	PUNCT
admet-470	175	1	additionally	additionally	ADV
admet-470	175	2	,	,	PUNCT
admet-470	175	3	higher	high	ADJ
admet-470	175	4	fuinc	fuinc	PROPN
admet-470	175	5	/	/	SYM
admet-470	175	6	fub	fub	PROPN
admet-470	175	7	ratios	ratio	NOUN
admet-470	175	8	lead	lead	VERB
admet-470	175	9	to	to	ADP
admet-470	175	10	lower	low	ADJ
admet-470	175	11	sensitivity	sensitivity	NOUN
admet-470	175	12	of	of	ADP
admet-470	175	13	the	the	DET
admet-470	175	14	intrinsic	intrinsic	ADJ
admet-470	175	15	clearance	clearance	NOUN
admet-470	175	16	as	as	ADV
admet-470	175	17	well	well	ADV
admet-470	175	18	as	as	ADP
admet-470	175	19	of	of	ADP
admet-470	175	20	volume	volume	NOUN
admet-470	175	21	of	of	ADP
admet-470	175	22	distribution	distribution	NOUN
admet-470	175	23	(	(	PUNCT
admet-470	175	24	see	see	VERB
admet-470	175	25	figure	figure	NOUN
admet-470	175	26	5	5	NUM
admet-470	175	27	,	,	PUNCT
admet-470	175	28	panel	panel	NOUN
admet-470	175	29	in	in	ADP
admet-470	175	30	upper	upper	ADJ
admet-470	175	31	right	right	ADJ
admet-470	175	32	corner	corner	NOUN
admet-470	175	33	)	)	PUNCT
admet-470	175	34	.	.	PUNCT
admet-470	176	1	lower	low	ADJ
admet-470	176	2	v	v	NOUN
admet-470	176	3	leads	lead	VERB
admet-470	176	4	to	to	ADP
admet-470	176	5	higher	high	ADJ
admet-470	176	6	threshold	threshold	NOUN
admet-470	176	7	pic50	pic50	ADJ
admet-470	176	8	values	value	NOUN
admet-470	176	9	and	and	CCONJ
admet-470	176	10	higher	high	ADJ
admet-470	176	11	fuinc	fuinc	PROPN
admet-470	176	12	/	/	SYM
admet-470	176	13	fub	fub	PROPN
admet-470	176	14	ratios	ratio	NOUN
admet-470	176	15	essentially	essentially	ADV
admet-470	176	16	lead	lead	VERB
admet-470	176	17	to	to	ADP
admet-470	176	18	lower	low	ADJ
admet-470	176	19	threshold	threshold	NOUN
admet-470	176	20	pic50s	pic50	NOUN
admet-470	176	21	,	,	PUNCT
admet-470	176	22	at	at	ADV
admet-470	176	23	least	least	ADJ
admet-470	176	24	as	as	ADV
admet-470	176	25	long	long	ADV
admet-470	176	26	as	as	ADP
admet-470	176	27	potency	potency	NOUN
admet-470	176	28	in	in	ADP
admet-470	176	29	blood	blood	NOUN
admet-470	176	30	assays	assay	NOUN
admet-470	176	31	,	,	PUNCT
admet-470	176	32	i.e.	i.e.	X
admet-470	176	33	,	,	PUNCT
admet-470	176	34	defined	define	VERB
admet-470	176	35	from	from	ADP
admet-470	176	36	total	total	ADJ
admet-470	176	37	concentrations	concentration	NOUN
admet-470	176	38	,	,	PUNCT
admet-470	176	39	is	be	AUX
admet-470	176	40	considered	consider	VERB
admet-470	176	41	.	.	PUNCT
admet-470	177	1	the	the	DET
admet-470	177	2	threshold	threshold	NOUN
admet-470	177	3	pic50	pic50	NOUN
admet-470	177	4	shifts	shift	NOUN
admet-470	177	5	up	up	ADP
admet-470	177	6	by	by	ADP
admet-470	177	7	three	three	NUM
admet-470	177	8	log	log	NOUN
admet-470	177	9	units	unit	NOUN
admet-470	177	10	in	in	ADP
admet-470	177	11	the	the	DET
admet-470	177	12	uppermost	uppermost	ADJ
admet-470	177	13	panel	panel	NOUN
admet-470	177	14	row	row	NOUN
admet-470	177	15	(	(	PUNCT
admet-470	177	16	fu	fu	NOUN
admet-470	177	17	=	=	NOUN
admet-470	177	18	0.001	0.001	NUM
admet-470	177	19	)	)	PUNCT
admet-470	177	20	when	when	SCONJ
admet-470	177	21	free	free	ADJ
admet-470	177	22	plasma	plasma	NOUN
admet-470	177	23	concentrations	concentration	NOUN
admet-470	177	24	are	be	AUX
admet-470	177	25	taken	take	VERB
admet-470	177	26	into	into	ADP
admet-470	177	27	account	account	NOUN
admet-470	177	28	,	,	PUNCT
admet-470	177	29	whereas	whereas	SCONJ
admet-470	177	30	the	the	DET
admet-470	177	31	threshold	threshold	NOUN
admet-470	177	32	pic50	pic50	NOUN
admet-470	177	33	in	in	ADP
admet-470	177	34	the	the	DET
admet-470	177	35	lower	low	ADJ
admet-470	177	36	panel	panel	NOUN
admet-470	177	37	row	row	NOUN
admet-470	177	38	(	(	PUNCT
admet-470	177	39	fu	fu	NOUN
admet-470	177	40	=	=	SYM
admet-470	177	41	0.3	0.3	NUM
admet-470	177	42	)	)	PUNCT
admet-470	177	43	shifts	shift	NOUN
admet-470	177	44	only	only	ADV
admet-470	177	45	by	by	ADP
admet-470	177	46	about	about	ADV
admet-470	177	47	0.5	0.5	NUM
admet-470	177	48	log	log	NOUN
admet-470	177	49	units	unit	NOUN
admet-470	177	50	.	.	PUNCT
admet-470	178	1	sensitivity	sensitivity	NOUN
admet-470	178	2	analysis	analysis	NOUN
admet-470	178	3	sensitivity	sensitivity	NOUN
admet-470	178	4	analysis	analysis	NOUN
admet-470	178	5	is	be	AUX
admet-470	178	6	a	a	DET
admet-470	178	7	useful	useful	ADJ
admet-470	178	8	tool	tool	NOUN
admet-470	178	9	for	for	ADP
admet-470	178	10	determining	determine	VERB
admet-470	178	11	which	which	PRON
admet-470	178	12	parameters	parameter	NOUN
admet-470	178	13	are	be	AUX
admet-470	178	14	important	important	ADJ
admet-470	178	15	.	.	PUNCT
admet-470	179	1	global	global	ADJ
admet-470	179	2	sensitivity	sensitivity	NOUN
admet-470	179	3	analysis	analysis	NOUN
admet-470	179	4	is	be	AUX
admet-470	179	5	used	use	VERB
admet-470	179	6	to	to	PART
admet-470	179	7	explore	explore	VERB
admet-470	179	8	the	the	DET
admet-470	179	9	entire	entire	ADJ
admet-470	179	10	parameter	parameter	NOUN
admet-470	179	11	space	space	NOUN
admet-470	179	12	,	,	PUNCT
admet-470	179	13	considering	consider	VERB
admet-470	179	14	physiologically	physiologically	ADV
admet-470	179	15	relevant	relevant	ADJ
admet-470	179	16	values	value	NOUN
admet-470	179	17	to	to	PART
admet-470	179	18	determine	determine	VERB
admet-470	179	19	the	the	DET
admet-470	179	20	relative	relative	ADJ
admet-470	179	21	importance	importance	NOUN
admet-470	179	22	of	of	ADP
admet-470	179	23	each	each	PRON
admet-470	179	24	of	of	ADP
admet-470	179	25	them	they	PRON
admet-470	179	26	.	.	PUNCT
admet-470	180	1	here	here	ADV
admet-470	180	2	it	it	PRON
admet-470	180	3	was	be	AUX
admet-470	180	4	shown	show	VERB
admet-470	180	5	that	that	SCONJ
admet-470	180	6	volume	volume	NOUN
admet-470	180	7	of	of	ADP
admet-470	180	8	distribution	distribution	NOUN
admet-470	180	9	is	be	AUX
admet-470	180	10	the	the	DET
admet-470	180	11	most	most	ADV
admet-470	180	12	influential	influential	ADJ
admet-470	180	13	parameter	parameter	NOUN
admet-470	180	14	by	by	ADP
admet-470	180	15	far	far	ADV
admet-470	180	16	(	(	PUNCT
admet-470	180	17	see	see	VERB
admet-470	180	18	figure	figure	NOUN
admet-470	180	19	6	6	NUM
admet-470	180	20	)	)	PUNCT
admet-470	180	21	.	.	PUNCT
admet-470	181	1	local	local	ADJ
admet-470	181	2	sensitivity	sensitivity	NOUN
admet-470	181	3	analysis	analysis	NOUN
admet-470	181	4	,	,	PUNCT
admet-470	181	5	on	on	ADP
admet-470	181	6	the	the	DET
admet-470	181	7	other	other	ADJ
admet-470	181	8	hand	hand	NOUN
admet-470	181	9	,	,	PUNCT
admet-470	181	10	can	can	AUX
admet-470	181	11	define	define	VERB
admet-470	181	12	how	how	SCONJ
admet-470	181	13	sensitive	sensitive	ADJ
admet-470	181	14	the	the	DET
admet-470	181	15	calculation	calculation	NOUN
admet-470	181	16	is	be	AUX
admet-470	181	17	to	to	ADP
admet-470	181	18	a	a	DET
admet-470	181	19	parameter	parameter	NOUN
admet-470	181	20	,	,	PUNCT
admet-470	181	21	when	when	SCONJ
admet-470	181	22	another	another	DET
admet-470	181	23	parameter	parameter	NOUN
admet-470	181	24	is	be	AUX
admet-470	181	25	scanned	scan	VERB
admet-470	181	26	over	over	ADP
admet-470	181	27	its	its	PRON
admet-470	181	28	defined	define	VERB
admet-470	181	29	range	range	NOUN
admet-470	181	30	.	.	PUNCT
admet-470	182	1	here	here	ADV
admet-470	182	2	,	,	PUNCT
admet-470	182	3	we	we	PRON
admet-470	182	4	checked	check	VERB
admet-470	182	5	the	the	DET
admet-470	182	6	influence	influence	NOUN
admet-470	182	7	of	of	ADP
admet-470	182	8	the	the	DET
admet-470	182	9	remaining	remain	VERB
admet-470	182	10	parameters	parameter	NOUN
admet-470	182	11	for	for	ADP
admet-470	182	12	different	different	ADJ
admet-470	182	13	values	value	NOUN
admet-470	182	14	of	of	ADP
admet-470	182	15	volume	volume	NOUN
admet-470	182	16	of	of	ADP
admet-470	182	17	distribution	distribution	NOUN
admet-470	182	18	(	(	PUNCT
admet-470	182	19	see	see	VERB
admet-470	182	20	figure	figure	NOUN
admet-470	182	21	7	7	NUM
admet-470	182	22	)	)	PUNCT
admet-470	182	23	.	.	PUNCT
admet-470	183	1	clinthh	clinthh	PROPN
admet-470	183	2	and	and	CCONJ
admet-470	183	3	fu	fu	PROPN
admet-470	183	4	have	have	AUX
admet-470	183	5	overlapping	overlap	VERB
admet-470	183	6	influence	influence	NOUN
admet-470	183	7	,	,	PUNCT
admet-470	183	8	considering	consider	VERB
admet-470	183	9	a	a	DET
admet-470	183	10	10	10	NUM
admet-470	183	11	%	%	NOUN
admet-470	183	12	change	change	NOUN
admet-470	183	13	,	,	PUNCT
admet-470	183	14	whereas	whereas	SCONJ
admet-470	183	15	fuinc	fuinc	PROPN
admet-470	183	16	is	be	AUX
admet-470	183	17	exacty	exacty	ADJ
admet-470	183	18	opposite	opposite	ADJ
admet-470	183	19	.	.	PUNCT
admet-470	184	1	since	since	SCONJ
admet-470	184	2	in	in	ADP
admet-470	184	3	vivo	vivo	NOUN
admet-470	184	4	clint	clint	NOUN
admet-470	184	5	is	be	AUX
admet-470	184	6	multiplied	multiply	VERB
admet-470	184	7	by	by	ADP
admet-470	184	8	fu	fu	PROPN
admet-470	184	9	,	,	PUNCT
admet-470	184	10	when	when	SCONJ
admet-470	184	11	calculating	calculate	VERB
admet-470	184	12	clb	clb	NOUN
admet-470	184	13	using	use	VERB
admet-470	184	14	the	the	DET
admet-470	184	15	well	well	ADV
admet-470	184	16	stirred	stir	VERB
admet-470	184	17	model	model	NOUN
admet-470	184	18	(	(	PUNCT
admet-470	184	19	eq	eq	NOUN
admet-470	184	20	.	.	NOUN
admet-470	184	21	5	5	NUM
admet-470	184	22	)	)	PUNCT
admet-470	184	23	and	and	CCONJ
admet-470	184	24	is	be	AUX
admet-470	184	25	calculated	calculate	VERB
admet-470	184	26	from	from	ADP
admet-470	184	27	clinthh	clinthh	ADV
admet-470	184	28	divided	divide	VERB
admet-470	184	29	by	by	ADP
admet-470	184	30	fuinc	fuinc	PROPN
admet-470	184	31	(	(	PUNCT
admet-470	184	32	eqs	eqs	X
admet-470	184	33	9	9	NUM
admet-470	184	34	and	and	CCONJ
admet-470	184	35	9a	9a	NOUN
admet-470	184	36	)	)	PUNCT
admet-470	184	37	this	this	PRON
admet-470	184	38	is	be	AUX
admet-470	184	39	not	not	PART
admet-470	184	40	really	really	ADV
admet-470	184	41	surprising	surprising	ADJ
admet-470	184	42	.	.	PUNCT
admet-470	185	1	note	note	VERB
admet-470	185	2	that	that	SCONJ
admet-470	185	3	the	the	DET
admet-470	185	4	influence	influence	NOUN
admet-470	185	5	of	of	ADP
admet-470	185	6	the	the	DET
admet-470	185	7	parameters	parameter	NOUN
admet-470	185	8	is	be	AUX
admet-470	185	9	highest	high	ADJ
admet-470	185	10	at	at	ADP
admet-470	185	11	low	low	ADJ
admet-470	185	12	volume	volume	NOUN
admet-470	185	13	of	of	ADP
admet-470	185	14	distribution	distribution	NOUN
admet-470	185	15	values	value	NOUN
admet-470	185	16	,	,	PUNCT
admet-470	185	17	decreases	decrease	VERB
admet-470	185	18	quickly	quickly	ADV
admet-470	185	19	and	and	CCONJ
admet-470	185	20	does	do	AUX
admet-470	185	21	not	not	PART
admet-470	185	22	change	change	VERB
admet-470	185	23	further	far	ADV
admet-470	185	24	as	as	ADV
admet-470	185	25	soon	soon	ADV
admet-470	185	26	as	as	SCONJ
admet-470	185	27	v	v	NOUN
admet-470	185	28	reaches	reach	VERB
admet-470	185	29	a	a	DET
admet-470	185	30	value	value	NOUN
admet-470	185	31	of	of	ADP
admet-470	185	32	2	2	NUM
admet-470	185	33	l	l	NOUN
admet-470	185	34	/	/	SYM
admet-470	185	35	kg	kg	PROPN
admet-470	185	36	.	.	PUNCT
admet-470	186	1	considering	consider	VERB
admet-470	186	2	typical	typical	ADJ
admet-470	186	3	volume	volume	NOUN
admet-470	186	4	ranges	range	VERB
admet-470	186	5	for	for	ADP
admet-470	186	6	acids	acid	NOUN
admet-470	186	7	,	,	PUNCT
admet-470	186	8	bases	basis	NOUN
admet-470	186	9	and	and	CCONJ
admet-470	186	10	neutrals	neutral	NOUN
admet-470	186	11	with	with	ADP
admet-470	186	12	median	median	ADJ
admet-470	186	13	values	value	NOUN
admet-470	186	14	of	of	ADP
admet-470	186	15	0.2	0.2	NUM
admet-470	186	16	l	l	NOUN
admet-470	186	17	/	/	SYM
admet-470	186	18	kg	kg	PROPN
admet-470	186	19	,	,	PUNCT
admet-470	186	20	2.9	2.9	NUM
admet-470	186	21	l	l	NOUN
admet-470	186	22	/	/	SYM
admet-470	186	23	kg	kg	PROPN
admet-470	186	24	and	and	CCONJ
admet-470	186	25	1.3	1.3	NUM
admet-470	186	26	l	l	NOUN
admet-470	186	27	/	/	SYM
admet-470	186	28	kg	kg	PROPN
admet-470	186	29	,	,	PUNCT
admet-470	186	30	respectively	respectively	ADV
admet-470	186	31	[	[	X
admet-470	186	32	10	10	NUM
admet-470	186	33	,	,	PUNCT
admet-470	186	34	17	17	NUM
admet-470	186	35	]	]	PUNCT
admet-470	186	36	,	,	PUNCT
admet-470	186	37	as	as	SCONJ
admet-470	186	38	indicated	indicate	VERB
admet-470	186	39	in	in	ADP
admet-470	186	40	figure	figure	NOUN
admet-470	186	41	7	7	NUM
admet-470	186	42	,	,	PUNCT
admet-470	186	43	it	it	PRON
admet-470	186	44	is	be	AUX
admet-470	186	45	clear	clear	ADJ
admet-470	186	46	that	that	SCONJ
admet-470	186	47	especially	especially	ADV
admet-470	186	48	for	for	ADP
admet-470	186	49	acids	acid	NOUN
admet-470	186	50	a	a	DET
admet-470	186	51	small	small	ADJ
admet-470	186	52	change	change	NOUN
admet-470	186	53	in	in	ADP
admet-470	186	54	either	either	PRON
admet-470	186	55	hepatocyte	hepatocyte	NOUN
admet-470	186	56	clint	clint	NOUN
admet-470	186	57	or	or	CCONJ
admet-470	186	58	binding	bind	VERB
admet-470	186	59	properties	property	NOUN
admet-470	186	60	can	can	AUX
admet-470	186	61	make	make	VERB
admet-470	186	62	a	a	DET
admet-470	186	63	big	big	ADJ
admet-470	186	64	difference	difference	NOUN
admet-470	186	65	for	for	ADP
admet-470	186	66	the	the	DET
admet-470	186	67	prediction	prediction	NOUN
admet-470	186	68	of	of	ADP
admet-470	186	69	threshold	threshold	NOUN
admet-470	186	70	pic50	pic50	NOUN
admet-470	186	71	determined	determine	VERB
admet-470	186	72	from	from	ADP
admet-470	186	73	cmin	cmin	PROPN
admet-470	186	74	.	.	PUNCT
admet-470	187	1	admet	admet	PROPN
admet-470	187	2	&	&	CCONJ
admet-470	187	3	dmpk	dmpk	PROPN
admet-470	187	4	6(1	6(1	NUM
admet-470	187	5	)	)	PUNCT
admet-470	187	6	(	(	PUNCT
admet-470	187	7	2018	2018	NUM
admet-470	187	8	)	)	PUNCT
admet-470	187	9	15	15	NUM
admet-470	187	10	-	-	SYM
admet-470	187	11	33	33	NUM
admet-470	187	12	in	in	ADP
admet-470	187	13	silico	silico	NOUN
admet-470	187	14	adme	adme	NOUN
admet-470	187	15	in	in	ADP
admet-470	187	16	drug	drug	NOUN
admet-470	187	17	design	design	NOUN
admet-470	187	18	doi	doi	NOUN
admet-470	187	19	:	:	PUNCT
admet-470	187	20	10.5599	10.5599	NUM
admet-470	187	21	/	/	SYM
admet-470	187	22	admet.6.1.470	admet.6.1.470	X
admet-470	187	23	29	29	NUM
admet-470	187	24	figure	figure	NOUN
admet-470	187	25	5	5	NUM
admet-470	187	26	.	.	PUNCT
admet-470	187	27	threshold	threshold	NOUN
admet-470	187	28	pic50	pic50	NOUN
admet-470	187	29	estimated	estimate	VERB
admet-470	187	30	from	from	ADP
admet-470	187	31	minimum	minimum	ADJ
admet-470	187	32	plasma	plasma	NOUN
admet-470	187	33	concentration	concentration	NOUN
admet-470	187	34	for	for	ADP
admet-470	187	35	hypothetical	hypothetical	ADJ
admet-470	187	36	compounds	compound	NOUN
admet-470	187	37	as	as	SCONJ
admet-470	187	38	calculated	calculate	VERB
admet-470	187	39	from	from	ADP
admet-470	187	40	human	human	ADJ
admet-470	187	41	hepatocyte	hepatocyte	PROPN
admet-470	187	42	clint	clint	NOUN
admet-470	187	43	values	value	NOUN
admet-470	187	44	(	(	PUNCT
admet-470	187	45	1	1	NUM
admet-470	187	46	-	-	SYM
admet-470	187	47	200	200	NUM
admet-470	187	48	µl	µl	NOUN
admet-470	187	49	/	/	SYM
admet-470	187	50	min/10	min/10	ADJ
admet-470	187	51	6	6	NUM
admet-470	187	52	cells	cell	NOUN
admet-470	187	53	,	,	PUNCT
admet-470	187	54	x	x	NOUN
admet-470	187	55	-	-	NOUN
admet-470	187	56	axis	axis	ADJ
admet-470	187	57	)	)	PUNCT
admet-470	187	58	,	,	PUNCT
admet-470	187	59	fraction	fraction	NOUN
admet-470	187	60	unbound	unbound	NOUN
admet-470	187	61	in	in	ADP
admet-470	187	62	the	the	DET
admet-470	187	63	incubation	incubation	NOUN
admet-470	187	64	(	(	PUNCT
admet-470	187	65	fuinc	fuinc	NOUN
admet-470	187	66	=	=	PUNCT
admet-470	187	67	0.01	0.01	NUM
admet-470	187	68	–	–	PUNCT
admet-470	187	69	0.7	0.7	NUM
admet-470	187	70	;	;	PUNCT
admet-470	187	71	panel	panel	NOUN
admet-470	187	72	columns	column	NOUN
admet-470	187	73	)	)	PUNCT
admet-470	187	74	,	,	PUNCT
admet-470	187	75	fraction	fraction	NOUN
admet-470	187	76	unbound	unbound	NOUN
admet-470	187	77	in	in	ADP
admet-470	187	78	blood	blood	NOUN
admet-470	187	79	(	(	PUNCT
admet-470	187	80	fub	fub	PROPN
admet-470	187	81	=	=	SYM
admet-470	187	82	0.001	0.001	NUM
admet-470	187	83	–	–	PUNCT
admet-470	187	84	0.3	0.3	NUM
admet-470	187	85	;	;	PUNCT
admet-470	187	86	panel	panel	NOUN
admet-470	187	87	rows	row	NOUN
admet-470	187	88	)	)	PUNCT
admet-470	187	89	,	,	PUNCT
admet-470	187	90	and	and	CCONJ
admet-470	187	91	volume	volume	NOUN
admet-470	187	92	of	of	ADP
admet-470	187	93	distribution	distribution	NOUN
admet-470	187	94	(	(	PUNCT
admet-470	187	95	v	v	NOUN
admet-470	187	96	=	=	SYM
admet-470	187	97	3	3	NUM
admet-470	187	98	l	l	NOUN
admet-470	187	99	/	/	SYM
admet-470	187	100	kg	kg	PROPN
admet-470	187	101	,	,	PUNCT
admet-470	187	102	black	black	ADJ
admet-470	187	103	,	,	PUNCT
admet-470	187	104	v	v	NOUN
admet-470	187	105	=	=	SYM
admet-470	187	106	2	2	NUM
admet-470	187	107	l	l	NOUN
admet-470	187	108	/	/	SYM
admet-470	187	109	kg	kg	PROPN
admet-470	187	110	,	,	PUNCT
admet-470	187	111	dark	dark	ADJ
admet-470	187	112	grey	grey	NOUN
admet-470	187	113	,	,	PUNCT
admet-470	187	114	v	v	NOUN
admet-470	187	115	=	=	SYM
admet-470	187	116	1	1	NUM
admet-470	187	117	l	l	NOUN
admet-470	187	118	/	/	SYM
admet-470	187	119	kg	kg	PROPN
admet-470	187	120	,	,	PUNCT
admet-470	187	121	medium	medium	ADJ
admet-470	187	122	grey	grey	NOUN
admet-470	187	123	,	,	PUNCT
admet-470	187	124	v	v	NOUN
admet-470	187	125	=	=	SYM
admet-470	187	126	0.4	0.4	NUM
admet-470	187	127	l	l	NOUN
admet-470	187	128	/	/	SYM
admet-470	187	129	kg	kg	PROPN
admet-470	187	130	,	,	PUNCT
admet-470	187	131	light	light	ADJ
admet-470	187	132	grey	grey	NOUN
admet-470	187	133	,	,	PUNCT
admet-470	187	134	v	v	NOUN
admet-470	187	135	=	=	SYM
admet-470	187	136	0.2	0.2	NUM
admet-470	187	137	l	l	NOUN
admet-470	187	138	/	/	SYM
admet-470	187	139	kg	kg	PROPN
admet-470	187	140	,	,	PUNCT
admet-470	187	141	very	very	ADV
admet-470	187	142	light	light	ADJ
admet-470	187	143	grey	grey	NOUN
admet-470	187	144	)	)	PUNCT
admet-470	187	145	.	.	PUNCT
admet-470	188	1	values	value	NOUN
admet-470	188	2	in	in	ADP
admet-470	188	3	the	the	DET
admet-470	188	4	corner	corner	NOUN
admet-470	188	5	of	of	ADP
admet-470	188	6	each	each	DET
admet-470	188	7	panel	panel	NOUN
admet-470	188	8	indicate	indicate	VERB
admet-470	188	9	the	the	DET
admet-470	188	10	fuinc	fuinc	PROPN
admet-470	188	11	/	/	SYM
admet-470	188	12	fub	fub	PROPN
admet-470	188	13	ratio	ratio	NOUN
admet-470	188	14	.	.	PUNCT
admet-470	189	1	lower	low	ADJ
admet-470	189	2	left	leave	VERB
admet-470	189	3	panels	panel	NOUN
admet-470	189	4	left	leave	VERB
admet-470	189	5	empty	empty	ADJ
admet-470	189	6	since	since	SCONJ
admet-470	189	7	compounds	compound	NOUN
admet-470	189	8	are	be	AUX
admet-470	189	9	usually	usually	ADV
admet-470	189	10	less	less	ADV
admet-470	189	11	bound	bind	VERB
admet-470	189	12	in	in	ADP
admet-470	189	13	the	the	DET
admet-470	189	14	hepatocyte	hepatocyte	NOUN
admet-470	189	15	incubation	incubation	NOUN
admet-470	189	16	than	than	ADP
admet-470	189	17	in	in	ADP
admet-470	189	18	plasma	plasma	NOUN
admet-470	189	19	.	.	PUNCT
admet-470	190	1	figure	figure	VERB
admet-470	190	2	6	6	NUM
admet-470	190	3	.	.	PUNCT
admet-470	191	1	global	global	ADJ
admet-470	191	2	sensitivity	sensitivity	NOUN
admet-470	191	3	towards	towards	ADP
admet-470	191	4	the	the	DET
admet-470	191	5	four	four	NUM
admet-470	191	6	parameters	parameter	NOUN
admet-470	191	7	to	to	PART
admet-470	191	8	determine	determine	VERB
admet-470	191	9	threshold	threshold	NOUN
admet-470	191	10	pic50	pic50	NOUN
admet-470	191	11	.	.	PUNCT
admet-470	192	1	susanne	susanne	PROPN
admet-470	192	2	winiwarter	winiwarter	PROPN
admet-470	192	3	et	et	PROPN
admet-470	192	4	al	al	PROPN
admet-470	192	5	.	.	PROPN
admet-470	192	6	admet	admet	PROPN
admet-470	192	7	&	&	CCONJ
admet-470	192	8	dmpk	dmpk	PROPN
admet-470	192	9	6(1	6(1	NUM
admet-470	192	10	)	)	PUNCT
admet-470	192	11	(	(	PUNCT
admet-470	192	12	2018	2018	NUM
admet-470	192	13	)	)	PUNCT
admet-470	192	14	15	15	NUM
admet-470	192	15	-	-	SYM
admet-470	192	16	33	33	NUM
admet-470	192	17	30	30	NUM
admet-470	192	18	figure	figure	NOUN
admet-470	192	19	7	7	NUM
admet-470	192	20	.	.	PUNCT
admet-470	192	21	sensitivity	sensitivity	NOUN
admet-470	192	22	of	of	ADP
admet-470	192	23	remaining	remain	VERB
admet-470	192	24	three	three	NUM
admet-470	192	25	parameters	parameter	NOUN
admet-470	192	26	for	for	ADP
admet-470	192	27	different	different	ADJ
admet-470	192	28	v	v	ADP
admet-470	192	29	values	value	NOUN
admet-470	192	30	(	(	PUNCT
admet-470	192	31	clinthh	clinthh	ADJ
admet-470	192	32	and	and	CCONJ
admet-470	192	33	fu	fu	VERB
admet-470	192	34	full	full	ADJ
admet-470	192	35	line	line	NOUN
admet-470	192	36	,	,	PUNCT
admet-470	192	37	fuinc	fuinc	PROPN
admet-470	192	38	dashed	dash	VERB
admet-470	192	39	line	line	NOUN
admet-470	192	40	;	;	PUNCT
admet-470	192	41	clint	clint	NOUN
admet-470	192	42	and	and	CCONJ
admet-470	192	43	fu	fu	NOUN
admet-470	192	44	have	have	VERB
admet-470	192	45	exactly	exactly	ADV
admet-470	192	46	same	same	ADJ
admet-470	192	47	influence	influence	NOUN
admet-470	192	48	and	and	CCONJ
admet-470	192	49	are	be	AUX
admet-470	192	50	on	on	ADP
admet-470	192	51	top	top	NOUN
admet-470	192	52	of	of	ADP
admet-470	192	53	each	each	DET
admet-470	192	54	other	other	ADJ
admet-470	192	55	,	,	PUNCT
admet-470	192	56	fuinc	fuinc	PROPN
admet-470	192	57	has	have	VERB
admet-470	192	58	opposite	opposite	ADJ
admet-470	192	59	effect	effect	NOUN
admet-470	192	60	)	)	PUNCT
admet-470	192	61	,	,	PUNCT
admet-470	192	62	areas	area	NOUN
admet-470	192	63	of	of	ADP
admet-470	192	64	typical	typical	ADJ
admet-470	192	65	distribution	distribution	NOUN
admet-470	192	66	volume	volume	NOUN
admet-470	192	67	values	value	NOUN
admet-470	192	68	for	for	ADP
admet-470	192	69	acids	acid	NOUN
admet-470	192	70	,	,	PUNCT
admet-470	192	71	bases	basis	NOUN
admet-470	192	72	and	and	CCONJ
admet-470	192	73	neutrals	neutral	NOUN
admet-470	192	74	indicated	indicate	VERB
admet-470	192	75	.	.	PUNCT
admet-470	193	1	influence	influence	NOUN
admet-470	193	2	of	of	ADP
admet-470	193	3	in	in	ADP
admet-470	193	4	silico	silico	NOUN
admet-470	193	5	model	model	NOUN
admet-470	193	6	quality	quality	NOUN
admet-470	193	7	the	the	DET
admet-470	193	8	quality	quality	NOUN
admet-470	193	9	of	of	ADP
admet-470	193	10	the	the	DET
admet-470	193	11	in	in	ADP
admet-470	193	12	silico	silico	NOUN
admet-470	193	13	models	model	NOUN
admet-470	193	14	needs	need	VERB
admet-470	193	15	to	to	PART
admet-470	193	16	be	be	AUX
admet-470	193	17	considered	consider	VERB
admet-470	193	18	for	for	ADP
admet-470	193	19	the	the	DET
admet-470	193	20	present	present	ADJ
admet-470	193	21	analysis	analysis	NOUN
admet-470	193	22	.	.	PUNCT
admet-470	194	1	here	here	ADV
admet-470	194	2	we	we	PRON
admet-470	194	3	use	use	VERB
admet-470	194	4	astrazeneca	astrazeneca	NOUN
admet-470	194	5	’s	’s	PART
admet-470	194	6	in	in	ADP
admet-470	194	7	-	-	PUNCT
admet-470	194	8	house	house	NOUN
admet-470	194	9	models	model	NOUN
admet-470	194	10	for	for	ADP
admet-470	194	11	the	the	DET
admet-470	194	12	five	five	NUM
admet-470	194	13	parameters	parameter	NOUN
admet-470	194	14	,	,	PUNCT
admet-470	194	15	two	two	NUM
admet-470	194	16	of	of	ADP
admet-470	194	17	which	which	PRON
admet-470	194	18	have	have	VERB
admet-470	194	19	rather	rather	ADV
admet-470	194	20	extensive	extensive	ADJ
admet-470	194	21	training	training	NOUN
admet-470	194	22	sets	set	NOUN
admet-470	194	23	with	with	ADP
admet-470	194	24	more	more	ADJ
admet-470	194	25	than	than	ADP
admet-470	194	26	10,000	10,000	NUM
admet-470	194	27	data	datum	NOUN
admet-470	194	28	points	point	NOUN
admet-470	194	29	each	each	PRON
admet-470	194	30	,	,	PUNCT
admet-470	194	31	gathered	gather	VERB
admet-470	194	32	over	over	ADP
admet-470	194	33	a	a	DET
admet-470	194	34	long	long	ADJ
admet-470	194	35	period	period	NOUN
admet-470	194	36	of	of	ADP
admet-470	194	37	time	time	NOUN
admet-470	194	38	(	(	PUNCT
admet-470	194	39	>	>	SYM
admet-470	194	40	10	10	NUM
admet-470	194	41	years	year	NOUN
admet-470	194	42	)	)	PUNCT
admet-470	194	43	,	,	PUNCT
admet-470	194	44	whereas	whereas	SCONJ
admet-470	194	45	two	two	NUM
admet-470	194	46	,	,	PUNCT
admet-470	194	47	fuinc	fuinc	PROPN
admet-470	194	48	and	and	CCONJ
admet-470	194	49	papp	papp	NOUN
admet-470	194	50	,	,	PUNCT
admet-470	194	51	have	have	VERB
admet-470	194	52	intermediate	intermediate	ADJ
admet-470	194	53	training	training	NOUN
admet-470	194	54	set	set	VERB
admet-470	194	55	size	size	NOUN
admet-470	194	56	,	,	PUNCT
admet-470	194	57	and	and	CCONJ
admet-470	194	58	the	the	DET
admet-470	194	59	fifth	fifth	ADJ
admet-470	194	60	,	,	PUNCT
admet-470	194	61	volume	volume	NOUN
admet-470	194	62	of	of	ADP
admet-470	194	63	distribution	distribution	NOUN
admet-470	194	64	,	,	PUNCT
admet-470	194	65	is	be	AUX
admet-470	194	66	based	base	VERB
admet-470	194	67	on	on	ADP
admet-470	194	68	literature	literature	NOUN
admet-470	194	69	data	datum	NOUN
admet-470	194	70	and	and	CCONJ
admet-470	194	71	uses	use	VERB
admet-470	194	72	only	only	ADV
admet-470	194	73	about	about	ADV
admet-470	194	74	500	500	NUM
admet-470	194	75	compounds	compound	NOUN
admet-470	194	76	.	.	PUNCT
admet-470	195	1	for	for	ADP
admet-470	195	2	the	the	DET
admet-470	195	3	four	four	NUM
admet-470	195	4	models	model	NOUN
admet-470	195	5	employing	employ	VERB
admet-470	195	6	in	in	ADP
admet-470	195	7	-	-	PUNCT
admet-470	195	8	house	house	NOUN
admet-470	195	9	data	datum	NOUN
admet-470	195	10	,	,	PUNCT
admet-470	195	11	about	about	ADV
admet-470	195	12	70	70	NUM
admet-470	195	13	-	-	SYM
admet-470	195	14	75	75	NUM
admet-470	195	15	%	%	NOUN
admet-470	195	16	of	of	ADP
admet-470	195	17	the	the	DET
admet-470	195	18	compounds	compound	NOUN
admet-470	195	19	within	within	ADP
admet-470	195	20	a	a	DET
admet-470	195	21	temporal	temporal	ADJ
admet-470	195	22	test	test	NOUN
admet-470	195	23	set	set	NOUN
admet-470	195	24	,	,	PUNCT
admet-470	195	25	i.e.	i.e.	X
admet-470	195	26	,	,	PUNCT
admet-470	195	27	compounds	compound	NOUN
admet-470	195	28	that	that	PRON
admet-470	195	29	have	have	AUX
admet-470	195	30	not	not	PART
admet-470	195	31	been	be	AUX
admet-470	195	32	available	available	ADJ
admet-470	195	33	when	when	SCONJ
admet-470	195	34	the	the	DET
admet-470	195	35	model	model	NOUN
admet-470	195	36	was	be	AUX
admet-470	195	37	built	build	VERB
admet-470	195	38	,	,	PUNCT
admet-470	195	39	were	be	AUX
admet-470	195	40	found	find	VERB
admet-470	195	41	to	to	PART
admet-470	195	42	be	be	AUX
admet-470	195	43	within	within	ADP
admet-470	195	44	3	3	NUM
admet-470	195	45	-	-	ADJ
admet-470	195	46	fold	fold	NOUN
admet-470	195	47	of	of	ADP
admet-470	195	48	the	the	DET
admet-470	195	49	experimental	experimental	ADJ
admet-470	195	50	value	value	NOUN
admet-470	195	51	.	.	PUNCT
admet-470	196	1	these	these	DET
admet-470	196	2	results	result	NOUN
admet-470	196	3	are	be	AUX
admet-470	196	4	rather	rather	ADV
admet-470	196	5	encouraging	encouraging	ADJ
admet-470	196	6	when	when	SCONJ
admet-470	196	7	considering	consider	VERB
admet-470	196	8	that	that	SCONJ
admet-470	196	9	the	the	DET
admet-470	196	10	experimental	experimental	ADJ
admet-470	196	11	variability	variability	NOUN
admet-470	196	12	in	in	ADP
admet-470	196	13	general	general	ADJ
admet-470	196	14	is	be	AUX
admet-470	196	15	assumed	assume	VERB
admet-470	196	16	to	to	PART
admet-470	196	17	be	be	AUX
admet-470	196	18	about	about	ADV
admet-470	196	19	2	2	NUM
admet-470	196	20	-	-	NUM
admet-470	196	21	fold	fold	VERB
admet-470	196	22	[	[	X
admet-470	196	23	38	38	NUM
admet-470	196	24	]	]	PUNCT
admet-470	196	25	.	.	PUNCT
admet-470	197	1	the	the	DET
admet-470	197	2	models	model	NOUN
admet-470	197	3	are	be	AUX
admet-470	197	4	being	be	AUX
admet-470	197	5	regularly	regularly	ADV
admet-470	197	6	updated	update	VERB
admet-470	197	7	,	,	PUNCT
admet-470	197	8	as	as	SCONJ
admet-470	197	9	it	it	PRON
admet-470	197	10	was	be	AUX
admet-470	197	11	shown	show	VERB
admet-470	197	12	earlier	early	ADV
admet-470	197	13	that	that	SCONJ
admet-470	197	14	continuous	continuous	ADJ
admet-470	197	15	updates	update	NOUN
admet-470	197	16	of	of	ADP
admet-470	197	17	models	model	NOUN
admet-470	197	18	enables	enable	VERB
admet-470	197	19	new	new	ADJ
admet-470	197	20	chemistry	chemistry	NOUN
admet-470	197	21	to	to	PART
admet-470	197	22	be	be	AUX
admet-470	197	23	well	well	ADV
admet-470	197	24	represented	represent	VERB
admet-470	197	25	and	and	CCONJ
admet-470	197	26	,	,	PUNCT
admet-470	197	27	thus	thus	ADV
admet-470	197	28	,	,	PUNCT
admet-470	197	29	likely	likely	ADV
admet-470	197	30	better	well	ADV
admet-470	197	31	predicted	predict	VERB
admet-470	197	32	by	by	ADP
admet-470	197	33	the	the	DET
admet-470	197	34	models	model	NOUN
admet-470	198	1	[	[	X
admet-470	198	2	39	39	NUM
admet-470	198	3	]	]	PUNCT
admet-470	198	4	.	.	PUNCT
admet-470	199	1	it	it	PRON
admet-470	199	2	should	should	AUX
admet-470	199	3	be	be	AUX
admet-470	199	4	emphasized	emphasize	VERB
admet-470	199	5	that	that	SCONJ
admet-470	199	6	the	the	DET
admet-470	199	7	predictivity	predictivity	NOUN
admet-470	199	8	of	of	ADP
admet-470	199	9	the	the	DET
admet-470	199	10	models	model	NOUN
admet-470	199	11	needs	need	VERB
admet-470	199	12	to	to	PART
admet-470	199	13	be	be	AUX
admet-470	199	14	investigated	investigate	VERB
admet-470	199	15	for	for	ADP
admet-470	199	16	the	the	DET
admet-470	199	17	drug	drug	NOUN
admet-470	199	18	discovery	discovery	NOUN
admet-470	199	19	project	project	NOUN
admet-470	199	20	or	or	CCONJ
admet-470	199	21	chemical	chemical	NOUN
admet-470	199	22	series	series	NOUN
admet-470	199	23	in	in	ADP
admet-470	199	24	question	question	NOUN
admet-470	199	25	when	when	SCONJ
admet-470	199	26	this	this	DET
admet-470	199	27	approach	approach	NOUN
admet-470	199	28	is	be	AUX
admet-470	199	29	to	to	PART
admet-470	199	30	be	be	AUX
admet-470	199	31	applied	apply	VERB
admet-470	199	32	.	.	PUNCT
admet-470	200	1	note	note	VERB
admet-470	200	2	that	that	SCONJ
admet-470	200	3	,	,	PUNCT
admet-470	200	4	as	as	SCONJ
admet-470	200	5	was	be	AUX
admet-470	200	6	shown	show	VERB
admet-470	200	7	in	in	ADP
admet-470	200	8	figure	figure	NOUN
admet-470	200	9	2	2	NUM
admet-470	200	10	,	,	PUNCT
admet-470	200	11	clearance	clearance	NOUN
admet-470	200	12	prediction	prediction	NOUN
admet-470	200	13	are	be	AUX
admet-470	200	14	reasonably	reasonably	ADV
admet-470	200	15	accurate	accurate	ADJ
admet-470	200	16	from	from	ADP
admet-470	200	17	in	in	ADP
admet-470	200	18	silico	silico	NOUN
admet-470	200	19	for	for	ADP
admet-470	200	20	most	most	ADJ
admet-470	200	21	compounds	compound	NOUN
admet-470	200	22	in	in	ADP
admet-470	200	23	data	datum	NOUN
admet-470	200	24	set	set	VERB
admet-470	200	25	2	2	NUM
admet-470	200	26	and	and	CCONJ
admet-470	200	27	can	can	AUX
admet-470	200	28	be	be	AUX
admet-470	200	29	directly	directly	ADV
admet-470	200	30	verified	verify	VERB
admet-470	200	31	as	as	ADV
admet-470	200	32	soon	soon	ADV
admet-470	200	33	as	as	SCONJ
admet-470	200	34	in	in	ADP
admet-470	200	35	vitro	vitro	X
admet-470	200	36	data	datum	NOUN
admet-470	200	37	is	be	AUX
admet-470	200	38	available	available	ADJ
admet-470	200	39	for	for	ADP
admet-470	200	40	a	a	DET
admet-470	200	41	compound	compound	NOUN
admet-470	200	42	.	.	PUNCT
admet-470	201	1	the	the	DET
admet-470	201	2	remaining	remain	VERB
admet-470	201	3	parameter	parameter	NOUN
admet-470	201	4	,	,	PUNCT
admet-470	201	5	human	human	ADJ
admet-470	201	6	distribution	distribution	NOUN
admet-470	201	7	volume	volume	NOUN
admet-470	201	8	,	,	PUNCT
admet-470	201	9	is	be	AUX
admet-470	201	10	less	less	ADV
admet-470	201	11	easily	easily	ADV
admet-470	201	12	available	available	ADJ
admet-470	201	13	.	.	PUNCT
admet-470	202	1	the	the	DET
admet-470	202	2	qsar	qsar	PROPN
admet-470	202	3	model	model	NOUN
admet-470	202	4	used	use	VERB
admet-470	202	5	here	here	ADV
admet-470	202	6	is	be	AUX
admet-470	202	7	based	base	VERB
admet-470	202	8	on	on	ADP
admet-470	202	9	human	human	PROPN
admet-470	202	10	literature	literature	NOUN
admet-470	202	11	data	datum	NOUN
admet-470	202	12	and	and	CCONJ
admet-470	202	13	can	can	AUX
admet-470	202	14	not	not	PART
admet-470	202	15	be	be	AUX
admet-470	202	16	updated	update	VERB
admet-470	202	17	as	as	ADP
admet-470	202	18	straightforwardly	straightforwardly	ADV
admet-470	202	19	as	as	ADP
admet-470	202	20	models	model	NOUN
admet-470	202	21	using	use	VERB
admet-470	202	22	data	datum	NOUN
admet-470	202	23	from	from	ADP
admet-470	202	24	in	in	ADP
admet-470	202	25	-	-	PUNCT
admet-470	202	26	house	house	NOUN
admet-470	202	27	screens	screen	NOUN
admet-470	202	28	.	.	PUNCT
admet-470	203	1	also	also	ADV
admet-470	203	2	,	,	PUNCT
admet-470	203	3	external	external	ADJ
admet-470	203	4	data	datum	NOUN
admet-470	203	5	is	be	AUX
admet-470	203	6	not	not	PART
admet-470	203	7	necessarily	necessarily	ADV
admet-470	203	8	relevant	relevant	ADJ
admet-470	203	9	to	to	PART
admet-470	203	10	newest	new	ADJ
admet-470	203	11	in	in	ADP
admet-470	203	12	-	-	PUNCT
admet-470	203	13	house	house	NOUN
admet-470	203	14	chemistry	chemistry	NOUN
admet-470	203	15	,	,	PUNCT
admet-470	203	16	and	and	CCONJ
admet-470	203	17	model	model	NOUN
admet-470	203	18	outcome	outcome	NOUN
admet-470	203	19	can	can	AUX
admet-470	203	20	usually	usually	ADV
admet-470	203	21	only	only	ADV
admet-470	203	22	be	be	AUX
admet-470	203	23	verified	verify	VERB
admet-470	203	24	at	at	ADP
admet-470	203	25	later	later	ADJ
admet-470	203	26	stages	stage	NOUN
admet-470	203	27	since	since	SCONJ
admet-470	203	28	in	in	ADP
admet-470	203	29	vivo	vivo	ADJ
admet-470	203	30	data	datum	NOUN
admet-470	203	31	is	be	AUX
admet-470	203	32	required	require	VERB
admet-470	203	33	.	.	PUNCT
admet-470	204	1	nevertheless	nevertheless	ADV
admet-470	204	2	,	,	PUNCT
admet-470	204	3	the	the	DET
admet-470	204	4	admet	admet	PROPN
admet-470	204	5	&	&	CCONJ
admet-470	204	6	dmpk	dmpk	PROPN
admet-470	204	7	6(1	6(1	NUM
admet-470	204	8	)	)	PUNCT
admet-470	204	9	(	(	PUNCT
admet-470	204	10	2018	2018	NUM
admet-470	204	11	)	)	PUNCT
admet-470	204	12	15	15	NUM
admet-470	204	13	-	-	SYM
admet-470	204	14	33	33	NUM
admet-470	204	15	in	in	ADP
admet-470	204	16	silico	silico	NOUN
admet-470	204	17	adme	adme	NOUN
admet-470	204	18	in	in	ADP
admet-470	204	19	drug	drug	NOUN
admet-470	204	20	design	design	NOUN
admet-470	204	21	doi	doi	NOUN
admet-470	204	22	:	:	PUNCT
admet-470	204	23	10.5599	10.5599	NUM
admet-470	204	24	/	/	SYM
admet-470	204	25	admet.6.1.470	admet.6.1.470	X
admet-470	204	26	31	31	NUM
admet-470	204	27	predictivity	predictivity	NOUN
admet-470	204	28	was	be	AUX
admet-470	204	29	considered	consider	VERB
admet-470	204	30	good	good	ADJ
admet-470	204	31	,	,	PUNCT
admet-470	204	32	with	with	ADP
admet-470	204	33	an	an	DET
admet-470	204	34	error	error	NOUN
admet-470	204	35	of	of	ADP
admet-470	204	36	prediction	prediction	NOUN
admet-470	204	37	to	to	PART
admet-470	204	38	be	be	AUX
admet-470	204	39	0.4	0.4	NUM
admet-470	204	40	log	log	NOUN
admet-470	204	41	units	unit	NOUN
admet-470	204	42	(	(	PUNCT
admet-470	204	43	2.5	2.5	NUM
admet-470	204	44	-	-	NUM
admet-470	204	45	fold	fold	ADJ
admet-470	204	46	)	)	PUNCT
admet-470	204	47	,	,	PUNCT
admet-470	204	48	and	and	CCONJ
admet-470	204	49	scrutinizing	scrutinize	VERB
admet-470	204	50	literature	literature	NOUN
admet-470	204	51	or	or	CCONJ
admet-470	204	52	databases	database	NOUN
admet-470	204	53	for	for	ADP
admet-470	204	54	new	new	ADJ
admet-470	204	55	data	datum	NOUN
admet-470	204	56	[	[	X
admet-470	204	57	40	40	NUM
admet-470	204	58	-	-	SYM
admet-470	204	59	42	42	NUM
admet-470	204	60	]	]	PUNCT
admet-470	204	61	in	in	ADP
admet-470	204	62	fairly	fairly	ADV
admet-470	204	63	regular	regular	ADJ
admet-470	204	64	intervals	interval	NOUN
admet-470	204	65	should	should	AUX
admet-470	204	66	ensure	ensure	VERB
admet-470	204	67	continued	continue	VERB
admet-470	204	68	high	high	ADJ
admet-470	204	69	quality	quality	NOUN
admet-470	204	70	of	of	ADP
admet-470	204	71	the	the	DET
admet-470	204	72	model	model	NOUN
admet-470	204	73	.	.	PUNCT
admet-470	205	1	conclusions	conclusion	NOUN
admet-470	205	2	the	the	DET
admet-470	205	3	present	present	ADJ
admet-470	205	4	study	study	NOUN
admet-470	205	5	suggests	suggest	VERB
admet-470	205	6	the	the	DET
admet-470	205	7	usage	usage	NOUN
admet-470	205	8	of	of	ADP
admet-470	205	9	in	in	ADP
admet-470	205	10	silico	silico	NOUN
admet-470	205	11	adme	adme	NOUN
admet-470	205	12	predictions	prediction	NOUN
admet-470	205	13	to	to	PART
admet-470	205	14	estimate	estimate	VERB
admet-470	205	15	which	which	DET
admet-470	205	16	plasma	plasma	NOUN
admet-470	205	17	concentration	concentration	NOUN
admet-470	205	18	a	a	DET
admet-470	205	19	new	new	ADJ
admet-470	205	20	chemical	chemical	NOUN
admet-470	205	21	structure	structure	NOUN
admet-470	205	22	may	may	AUX
admet-470	205	23	achieve	achieve	VERB
admet-470	205	24	when	when	SCONJ
admet-470	205	25	given	give	VERB
admet-470	205	26	orally	orally	ADV
admet-470	205	27	using	use	VERB
admet-470	205	28	a	a	DET
admet-470	205	29	defined	define	VERB
admet-470	205	30	dose	dose	NOUN
admet-470	205	31	and	and	CCONJ
admet-470	205	32	dosing	dose	VERB
admet-470	205	33	regimen	regiman	NOUN
admet-470	205	34	.	.	PUNCT
admet-470	206	1	from	from	ADP
admet-470	206	2	the	the	DET
admet-470	206	3	plasma	plasma	NOUN
admet-470	206	4	concentration	concentration	NOUN
admet-470	206	5	a	a	DET
admet-470	206	6	minimum	minimum	NOUN
admet-470	206	7	required	require	VERB
admet-470	206	8	potency	potency	NOUN
admet-470	206	9	can	can	AUX
admet-470	206	10	be	be	AUX
admet-470	206	11	deduced	deduce	VERB
admet-470	206	12	,	,	PUNCT
admet-470	206	13	here	here	ADV
admet-470	206	14	referred	refer	VERB
admet-470	206	15	to	to	ADP
admet-470	206	16	as	as	ADP
admet-470	206	17	threshold	threshold	NOUN
admet-470	206	18	potency	potency	NOUN
admet-470	206	19	(	(	PUNCT
admet-470	206	20	or	or	CCONJ
admet-470	206	21	threshold	threshold	NOUN
admet-470	206	22	pic50	pic50	NOUN
admet-470	206	23	)	)	PUNCT
admet-470	206	24	.	.	PUNCT
admet-470	207	1	while	while	SCONJ
admet-470	207	2	it	it	PRON
admet-470	207	3	was	be	AUX
admet-470	207	4	postulated	postulate	VERB
admet-470	207	5	,	,	PUNCT
admet-470	207	6	that	that	SCONJ
admet-470	207	7	early	early	ADJ
admet-470	207	8	dose	dose	NOUN
admet-470	207	9	predictions	prediction	NOUN
admet-470	207	10	from	from	ADP
admet-470	207	11	in	in	ADP
admet-470	207	12	silico	silico	NOUN
admet-470	207	13	was	be	AUX
admet-470	207	14	not	not	PART
admet-470	207	15	yet	yet	ADV
admet-470	207	16	possible	possible	ADJ
admet-470	207	17	[	[	X
admet-470	207	18	10	10	NUM
admet-470	207	19	]	]	PUNCT
admet-470	207	20	,	,	PUNCT
admet-470	207	21	the	the	DET
admet-470	207	22	idea	idea	NOUN
admet-470	207	23	here	here	ADV
admet-470	207	24	is	be	AUX
admet-470	207	25	to	to	PART
admet-470	207	26	utilise	utilise	VERB
admet-470	207	27	predictions	prediction	NOUN
admet-470	207	28	only	only	ADV
admet-470	207	29	to	to	PART
admet-470	207	30	consider	consider	VERB
admet-470	207	31	a	a	DET
admet-470	207	32	compound	compound	NOUN
admet-470	207	33	’s	’s	PART
admet-470	207	34	summarized	summarize	VERB
admet-470	207	35	pharmacokinetic	pharmacokinetic	ADJ
admet-470	207	36	properties	property	NOUN
admet-470	207	37	for	for	ADP
admet-470	207	38	ranking	ranking	ADJ
admet-470	207	39	compounds	compound	NOUN
admet-470	207	40	within	within	ADP
admet-470	207	41	a	a	DET
admet-470	207	42	series	series	NOUN
admet-470	207	43	early	early	ADV
admet-470	207	44	on	on	ADV
admet-470	207	45	in	in	ADP
admet-470	207	46	the	the	DET
admet-470	207	47	design	design	NOUN
admet-470	207	48	process	process	NOUN
admet-470	207	49	.	.	PUNCT
admet-470	208	1	combining	combine	VERB
admet-470	208	2	the	the	DET
admet-470	208	3	in	in	ADP
admet-470	208	4	silico	silico	NOUN
admet-470	208	5	predictions	prediction	NOUN
admet-470	208	6	to	to	ADP
admet-470	208	7	a	a	DET
admet-470	208	8	physiologically	physiologically	ADV
admet-470	208	9	meaningful	meaningful	ADJ
admet-470	208	10	score	score	NOUN
admet-470	208	11	,	,	PUNCT
admet-470	208	12	reduces	reduce	VERB
admet-470	208	13	the	the	DET
admet-470	208	14	risk	risk	NOUN
admet-470	208	15	of	of	ADP
admet-470	208	16	deselecting	deselecte	VERB
admet-470	208	17	a	a	DET
admet-470	208	18	compound	compound	NOUN
admet-470	208	19	just	just	ADV
admet-470	208	20	because	because	SCONJ
admet-470	208	21	one	one	NUM
admet-470	208	22	of	of	ADP
admet-470	208	23	the	the	DET
admet-470	208	24	parameters	parameter	NOUN
admet-470	208	25	is	be	AUX
admet-470	208	26	outside	outside	ADP
admet-470	208	27	an	an	DET
admet-470	208	28	arbitrarily	arbitrarily	ADV
admet-470	208	29	chosen	choose	VERB
admet-470	208	30	limit	limit	NOUN
admet-470	208	31	.	.	PUNCT
admet-470	209	1	using	use	VERB
admet-470	209	2	the	the	DET
admet-470	209	3	approach	approach	NOUN
admet-470	209	4	for	for	ADP
admet-470	209	5	a	a	DET
admet-470	209	6	set	set	NOUN
admet-470	209	7	of	of	ADP
admet-470	209	8	drug	drug	NOUN
admet-470	209	9	discovery	discovery	NOUN
admet-470	209	10	compounds	compound	NOUN
admet-470	209	11	,	,	PUNCT
admet-470	209	12	it	it	PRON
admet-470	209	13	was	be	AUX
admet-470	209	14	shown	show	VERB
admet-470	209	15	that	that	SCONJ
admet-470	209	16	the	the	DET
admet-470	209	17	threshold	threshold	NOUN
admet-470	209	18	pic50	pic50	NOUN
admet-470	209	19	was	be	AUX
admet-470	209	20	able	able	ADJ
admet-470	209	21	to	to	PART
admet-470	209	22	define	define	VERB
admet-470	209	23	which	which	DET
admet-470	209	24	compounds	compound	NOUN
admet-470	209	25	had	have	VERB
admet-470	209	26	a	a	DET
admet-470	209	27	higher	high	ADJ
admet-470	209	28	or	or	CCONJ
admet-470	209	29	lower	low	ADJ
admet-470	209	30	chance	chance	NOUN
admet-470	209	31	of	of	ADP
admet-470	209	32	success	success	NOUN
admet-470	209	33	,	,	PUNCT
admet-470	209	34	with	with	ADP
admet-470	209	35	the	the	DET
admet-470	209	36	finally	finally	ADV
admet-470	209	37	selected	select	VERB
admet-470	209	38	compound	compound	NOUN
admet-470	209	39	in	in	ADP
admet-470	209	40	the	the	DET
admet-470	209	41	former	former	ADJ
admet-470	209	42	set	set	NOUN
admet-470	209	43	.	.	PUNCT
admet-470	210	1	it	it	PRON
admet-470	210	2	was	be	AUX
admet-470	210	3	assumed	assume	VERB
admet-470	210	4	that	that	SCONJ
admet-470	210	5	the	the	DET
admet-470	210	6	approach	approach	NOUN
admet-470	210	7	is	be	AUX
admet-470	210	8	most	most	ADV
admet-470	210	9	useful	useful	ADJ
admet-470	210	10	in	in	ADP
admet-470	210	11	lead	lead	ADJ
admet-470	210	12	optimisation	optimisation	NOUN
admet-470	210	13	stage	stage	NOUN
admet-470	210	14	,	,	PUNCT
admet-470	210	15	when	when	SCONJ
admet-470	210	16	the	the	DET
admet-470	210	17	requirements	requirement	NOUN
admet-470	210	18	for	for	ADP
admet-470	210	19	potency	potency	NOUN
admet-470	210	20	coverage	coverage	NOUN
admet-470	210	21	are	be	AUX
admet-470	210	22	known	know	VERB
admet-470	210	23	.	.	PUNCT
admet-470	211	1	additionally	additionally	ADV
admet-470	211	2	,	,	PUNCT
admet-470	211	3	it	it	PRON
admet-470	211	4	was	be	AUX
admet-470	211	5	shown	show	VERB
admet-470	211	6	that	that	SCONJ
admet-470	211	7	the	the	DET
admet-470	211	8	threshold	threshold	NOUN
admet-470	211	9	potency	potency	NOUN
admet-470	211	10	values	value	NOUN
admet-470	211	11	calculated	calculate	VERB
admet-470	211	12	for	for	ADP
admet-470	211	13	a	a	DET
admet-470	211	14	set	set	NOUN
admet-470	211	15	of	of	ADP
admet-470	211	16	marketed	market	VERB
admet-470	211	17	drugs	drug	NOUN
admet-470	211	18	were	be	AUX
admet-470	211	19	in	in	ADP
admet-470	211	20	a	a	DET
admet-470	211	21	reasonable	reasonable	ADJ
admet-470	211	22	range	range	NOUN
admet-470	211	23	for	for	ADP
admet-470	211	24	most	most	ADJ
admet-470	211	25	of	of	ADP
admet-470	211	26	the	the	DET
admet-470	211	27	compounds	compound	NOUN
admet-470	211	28	,	,	PUNCT
admet-470	211	29	when	when	SCONJ
admet-470	211	30	appropriate	appropriate	ADJ
admet-470	211	31	dosing	dosing	ADJ
admet-470	211	32	regimens	regimen	NOUN
admet-470	211	33	were	be	AUX
admet-470	211	34	considered	consider	VERB
admet-470	211	35	for	for	ADP
admet-470	211	36	each	each	PRON
admet-470	211	37	.	.	PUNCT
admet-470	212	1	these	these	DET
admet-470	212	2	results	result	NOUN
admet-470	212	3	were	be	AUX
admet-470	212	4	also	also	ADV
admet-470	212	5	compared	compare	VERB
admet-470	212	6	with	with	ADP
admet-470	212	7	the	the	DET
admet-470	212	8	outcome	outcome	NOUN
admet-470	212	9	,	,	PUNCT
admet-470	212	10	when	when	SCONJ
admet-470	212	11	experimental	experimental	ADJ
admet-470	212	12	in	in	ADP
admet-470	212	13	vitro	vitro	X
admet-470	212	14	or	or	CCONJ
admet-470	212	15	human	human	NOUN
admet-470	212	16	in	in	ADP
admet-470	212	17	vivo	vivo	ADJ
admet-470	212	18	data	datum	NOUN
admet-470	212	19	were	be	AUX
admet-470	212	20	considered	consider	VERB
admet-470	212	21	as	as	ADP
admet-470	212	22	input	input	NOUN
admet-470	212	23	for	for	ADP
admet-470	212	24	the	the	DET
admet-470	212	25	same	same	ADJ
admet-470	212	26	procedure	procedure	NOUN
admet-470	212	27	.	.	PUNCT
admet-470	213	1	in	in	ADP
admet-470	213	2	silico	silico	NOUN
admet-470	213	3	outcome	outcome	NOUN
admet-470	213	4	was	be	AUX
admet-470	213	5	in	in	ADP
admet-470	213	6	many	many	ADJ
admet-470	213	7	cases	case	NOUN
admet-470	213	8	similar	similar	ADJ
admet-470	213	9	to	to	ADP
admet-470	213	10	both	both	PRON
admet-470	213	11	in	in	ADP
admet-470	213	12	vitro	vitro	X
admet-470	213	13	and	and	CCONJ
admet-470	213	14	in	in	ADP
admet-470	213	15	vivo	vivo	NOUN
admet-470	213	16	,	,	PUNCT
admet-470	213	17	and	and	CCONJ
admet-470	213	18	when	when	SCONJ
admet-470	213	19	there	there	PRON
admet-470	213	20	were	be	VERB
admet-470	213	21	bigger	big	ADJ
admet-470	213	22	differences	difference	NOUN
admet-470	213	23	usually	usually	ADV
admet-470	213	24	the	the	DET
admet-470	213	25	in	in	NOUN
admet-470	213	26	vitro	vitro	X
admet-470	213	27	was	be	AUX
admet-470	213	28	closer	close	ADJ
admet-470	213	29	to	to	ADP
admet-470	213	30	the	the	DET
admet-470	213	31	in	in	ADJ
admet-470	213	32	vivo	vivo	NOUN
admet-470	213	33	outcome	outcome	NOUN
admet-470	213	34	.	.	PUNCT
admet-470	214	1	thus	thus	ADV
admet-470	214	2	,	,	PUNCT
admet-470	214	3	in	in	ADP
admet-470	214	4	silico	silico	NOUN
admet-470	214	5	prediction	prediction	NOUN
admet-470	214	6	can	can	AUX
admet-470	214	7	be	be	AUX
admet-470	214	8	easily	easily	ADV
admet-470	214	9	verified	verify	VERB
admet-470	214	10	by	by	ADP
admet-470	214	11	in	in	ADP
admet-470	214	12	vitro	vitro	X
admet-470	214	13	experiments	experiment	NOUN
admet-470	214	14	as	as	ADV
admet-470	214	15	soon	soon	ADV
admet-470	214	16	as	as	SCONJ
admet-470	214	17	a	a	DET
admet-470	214	18	compound	compound	NOUN
admet-470	214	19	is	be	AUX
admet-470	214	20	made	make	VERB
admet-470	214	21	.	.	PUNCT
admet-470	215	1	the	the	DET
admet-470	215	2	examples	example	NOUN
admet-470	215	3	shown	show	VERB
admet-470	215	4	here	here	ADV
admet-470	215	5	based	base	VERB
admet-470	215	6	threshold	threshold	NOUN
admet-470	215	7	potency	potency	NOUN
admet-470	215	8	values	value	NOUN
admet-470	215	9	on	on	ADP
admet-470	215	10	oral	oral	ADJ
admet-470	215	11	dosing	dosing	NOUN
admet-470	215	12	and	and	CCONJ
admet-470	215	13	minimum	minimum	ADJ
admet-470	215	14	concentration	concentration	NOUN
admet-470	215	15	,	,	PUNCT
admet-470	215	16	i.e.	i.e.	X
admet-470	215	17	,	,	PUNCT
admet-470	215	18	required	require	VERB
admet-470	215	19	coverage	coverage	NOUN
admet-470	215	20	over	over	ADP
admet-470	215	21	the	the	DET
admet-470	215	22	whole	whole	ADJ
admet-470	215	23	dosing	dose	VERB
admet-470	215	24	period	period	NOUN
admet-470	215	25	.	.	PUNCT
admet-470	216	1	using	use	VERB
admet-470	216	2	such	such	DET
admet-470	216	3	a	a	DET
admet-470	216	4	dosing	dose	VERB
admet-470	216	5	regimen	regimen	NOUN
admet-470	216	6	,	,	PUNCT
admet-470	216	7	and	and	CCONJ
admet-470	216	8	based	base	VERB
admet-470	216	9	on	on	ADP
admet-470	216	10	a	a	DET
admet-470	216	11	one	one	NUM
admet-470	216	12	compartment	compartment	NOUN
admet-470	216	13	pharmacokinetic	pharmacokinetic	ADJ
admet-470	216	14	model	model	NOUN
admet-470	216	15	considering	consider	VERB
admet-470	216	16	immediate	immediate	ADJ
admet-470	216	17	absorption	absorption	NOUN
admet-470	216	18	,	,	PUNCT
admet-470	216	19	volume	volume	NOUN
admet-470	216	20	of	of	ADP
admet-470	216	21	distribution	distribution	NOUN
admet-470	216	22	becomes	become	VERB
admet-470	216	23	the	the	DET
admet-470	216	24	most	most	ADV
admet-470	216	25	important	important	ADJ
admet-470	216	26	factor	factor	NOUN
admet-470	216	27	.	.	PUNCT
admet-470	217	1	special	special	ADJ
admet-470	217	2	care	care	NOUN
admet-470	217	3	needs	need	VERB
admet-470	217	4	to	to	PART
admet-470	217	5	be	be	AUX
admet-470	217	6	taken	take	VERB
admet-470	217	7	for	for	ADP
admet-470	217	8	low	low	ADJ
admet-470	217	9	volume	volume	NOUN
admet-470	217	10	compounds	compound	NOUN
admet-470	217	11	such	such	ADJ
admet-470	217	12	as	as	ADP
admet-470	217	13	acids	acid	NOUN
admet-470	217	14	.	.	PUNCT
admet-470	218	1	obviously	obviously	ADV
admet-470	218	2	,	,	PUNCT
admet-470	218	3	the	the	DET
admet-470	218	4	equations	equation	NOUN
admet-470	218	5	can	can	AUX
admet-470	218	6	be	be	AUX
admet-470	218	7	adapted	adapt	VERB
admet-470	218	8	to	to	ADP
admet-470	218	9	other	other	ADJ
admet-470	218	10	coverage	coverage	NOUN
admet-470	218	11	periods	period	NOUN
admet-470	218	12	or	or	CCONJ
admet-470	218	13	dosing	dose	VERB
admet-470	218	14	regimen	regiman	NOUN
admet-470	218	15	,	,	PUNCT
admet-470	218	16	as	as	SCONJ
admet-470	218	17	required	require	VERB
admet-470	218	18	by	by	ADP
admet-470	218	19	the	the	DET
admet-470	218	20	specific	specific	ADJ
admet-470	218	21	drug	drug	NOUN
admet-470	218	22	discovery	discovery	NOUN
admet-470	218	23	project	project	NOUN
admet-470	218	24	.	.	PUNCT
admet-470	219	1	references	reference	NOUN
admet-470	219	2	[	[	X
admet-470	219	3	1	1	X
admet-470	219	4	]	]	PUNCT
admet-470	219	5	s.	s.	PROPN
admet-470	219	6	ekins	ekins	PROPN
admet-470	219	7	,	,	PUNCT
admet-470	219	8	j.	j.	PROPN
admet-470	219	9	rose	rise	VERB
admet-470	219	10	.	.	PUNCT
admet-470	220	1	in	in	ADP
admet-470	220	2	silico	silico	NOUN
admet-470	220	3	adme	adme	NOUN
admet-470	220	4	/	/	SYM
admet-470	220	5	tox	tox	NOUN
admet-470	220	6	:	:	PUNCT
admet-470	220	7	the	the	DET
admet-470	220	8	state	state	NOUN
admet-470	220	9	of	of	ADP
admet-470	220	10	the	the	DET
admet-470	220	11	art	art	NOUN
admet-470	220	12	.	.	PUNCT
admet-470	221	1	journal	journal	NOUN
admet-470	221	2	of	of	ADP
admet-470	221	3	molecular	molecular	ADJ
admet-470	221	4	graphics	graphic	NOUN
admet-470	221	5	and	and	CCONJ
admet-470	221	6	modelling	model	VERB
admet-470	221	7	20	20	NUM
admet-470	221	8	(	(	PUNCT
admet-470	221	9	2002	2002	NUM
admet-470	221	10	)	)	PUNCT
admet-470	221	11	305	305	NUM
admet-470	221	12	-	-	SYM
admet-470	221	13	309	309	NUM
admet-470	221	14	.	.	PUNCT
admet-470	222	1	[	[	X
admet-470	222	2	2	2	X
admet-470	222	3	]	]	PUNCT
admet-470	222	4	h.	h.	PROPN
admet-470	222	5	van	van	PROPN
admet-470	222	6	de	de	PROPN
admet-470	222	7	waterbeemd	waterbeemd	PROPN
admet-470	222	8	,	,	PUNCT
admet-470	222	9	e.	e.	PROPN
admet-470	222	10	gifford	gifford	PROPN
admet-470	222	11	.	.	PUNCT
admet-470	223	1	admet	admet	PROPN
admet-470	223	2	in	in	ADP
admet-470	223	3	silico	silico	NOUN
admet-470	223	4	modelling	modelling	NOUN
admet-470	223	5	:	:	PUNCT
admet-470	223	6	towards	towards	ADP
admet-470	223	7	prediction	prediction	NOUN
admet-470	223	8	paradise	paradise	PROPN
admet-470	223	9	?	?	PUNCT
admet-470	224	1	nature	nature	NOUN
admet-470	224	2	reviews	review	VERB
admet-470	224	3	drug	drug	NOUN
admet-470	224	4	discovery	discovery	NOUN
admet-470	224	5	2	2	NUM
admet-470	224	6	(	(	PUNCT
admet-470	224	7	2003	2003	NUM
admet-470	224	8	)	)	PUNCT
admet-470	224	9	192	192	NUM
admet-470	224	10	-	-	SYM
admet-470	224	11	204	204	NUM
admet-470	224	12	.	.	PUNCT
admet-470	225	1	[	[	X
admet-470	225	2	3	3	X
admet-470	225	3	]	]	X
admet-470	225	4	m.p	m.p	PROPN
admet-470	225	5	.	.	PROPN
admet-470	225	6	gleeson	gleeson	PROPN
admet-470	225	7	,	,	PUNCT
admet-470	225	8	a.	a.	PROPN
admet-470	225	9	hersey	hersey	PROPN
admet-470	225	10	,	,	PUNCT
admet-470	225	11	s.	s.	PROPN
admet-470	225	12	hannongbua	hannongbua	PROPN
admet-470	225	13	.	.	PUNCT
admet-470	226	1	in	in	ADP
admet-470	226	2	-	-	PUNCT
admet-470	226	3	silico	silico	NOUN
admet-470	226	4	adme	adme	NOUN
admet-470	226	5	models	model	NOUN
admet-470	226	6	:	:	PUNCT
admet-470	226	7	a	a	DET
admet-470	226	8	general	general	ADJ
admet-470	226	9	assessment	assessment	NOUN
admet-470	226	10	of	of	ADP
admet-470	226	11	their	their	PRON
admet-470	226	12	utility	utility	NOUN
admet-470	226	13	in	in	ADP
admet-470	226	14	drug	drug	NOUN
admet-470	226	15	discovery	discovery	NOUN
admet-470	226	16	applications	application	NOUN
admet-470	226	17	.	.	PUNCT
admet-470	227	1	curr	curr	PROPN
admet-470	227	2	top	top	ADJ
admet-470	227	3	med	med	ADJ
admet-470	227	4	chem	chem	NOUN
admet-470	227	5	11	11	NUM
admet-470	227	6	(	(	PUNCT
admet-470	227	7	2011	2011	NUM
admet-470	227	8	)	)	PUNCT
admet-470	227	9	358	358	NUM
admet-470	227	10	-	-	SYM
admet-470	227	11	381	381	NUM
admet-470	227	12	.	.	PUNCT
admet-470	228	1	[	[	X
admet-470	228	2	4	4	X
admet-470	228	3	]	]	PUNCT
admet-470	228	4	l.	l.	PROPN
admet-470	228	5	tao	tao	PROPN
admet-470	228	6	,	,	PUNCT
admet-470	228	7	p.	p.	PROPN
admet-470	228	8	zhang	zhang	PROPN
admet-470	228	9	,	,	PUNCT
admet-470	228	10	c.	c.	PROPN
admet-470	228	11	qin	qin	PROPN
admet-470	228	12	,	,	PUNCT
admet-470	228	13	s.y	s.y	PROPN
admet-470	228	14	.	.	PROPN
admet-470	228	15	chen	chen	PROPN
admet-470	228	16	,	,	PUNCT
admet-470	228	17	c.	c.	PROPN
admet-470	228	18	zhang	zhang	PROPN
admet-470	228	19	,	,	PUNCT
admet-470	228	20	z.	z.	PROPN
admet-470	228	21	chen	chen	PROPN
admet-470	228	22	,	,	PUNCT
admet-470	228	23	f.	f.	PROPN
admet-470	228	24	zhu	zhu	PROPN
admet-470	228	25	,	,	PUNCT
admet-470	228	26	s.y	s.y	PROPN
admet-470	228	27	.	.	PROPN
admet-470	228	28	yang	yang	PROPN
admet-470	228	29	,	,	PUNCT
admet-470	228	30	y.q	y.q	PROPN
admet-470	228	31	.	.	PROPN
admet-470	228	32	wei	wei	PROPN
admet-470	228	33	,	,	PUNCT
admet-470	228	34	y.z	y.z	PROPN
admet-470	228	35	.	.	PROPN
admet-470	228	36	chen	chen	PROPN
admet-470	228	37	.	.	PUNCT
admet-470	229	1	recent	recent	ADJ
admet-470	229	2	progresses	progress	NOUN
admet-470	229	3	in	in	ADP
admet-470	229	4	the	the	DET
admet-470	229	5	exploration	exploration	NOUN
admet-470	229	6	of	of	ADP
admet-470	229	7	machine	machine	NOUN
admet-470	229	8	learning	learning	NOUN
admet-470	229	9	methods	method	NOUN
admet-470	229	10	as	as	ADP
admet-470	229	11	in	in	ADP
admet-470	229	12	-	-	PUNCT
admet-470	229	13	silico	silico	NOUN
admet-470	229	14	adme	adme	NOUN
admet-470	229	15	prediction	prediction	NOUN
admet-470	229	16	tools	tool	NOUN
admet-470	229	17	.	.	PUNCT
admet-470	230	1	advanced	advanced	ADJ
admet-470	230	2	drug	drug	NOUN
admet-470	230	3	delivery	delivery	NOUN
admet-470	230	4	reviews	review	VERB
admet-470	230	5	86	86	NUM
admet-470	230	6	(	(	PUNCT
admet-470	230	7	2015	2015	NUM
admet-470	230	8	)	)	PUNCT
admet-470	230	9	83	83	NUM
admet-470	230	10	-	-	SYM
admet-470	230	11	100	100	NUM
admet-470	230	12	.	.	PUNCT
admet-470	231	1	[	[	X
admet-470	231	2	5	5	NUM
admet-470	231	3	]	]	PUNCT
admet-470	231	4	f.	f.	PROPN
admet-470	231	5	lombardo	lombardo	PROPN
admet-470	231	6	,	,	PUNCT
admet-470	231	7	e.	e.	PROPN
admet-470	231	8	gifford	gifford	PROPN
admet-470	231	9	,	,	PUNCT
admet-470	231	10	m.y	m.y	PROPN
admet-470	231	11	.	.	PROPN
admet-470	231	12	shalaeva	shalaeva	PROPN
admet-470	231	13	.	.	PUNCT
admet-470	232	1	in	in	ADP
admet-470	232	2	silico	silico	NOUN
admet-470	232	3	adme	adme	NOUN
admet-470	232	4	prediction	prediction	NOUN
admet-470	232	5	:	:	PUNCT
admet-470	232	6	data	datum	NOUN
admet-470	232	7	,	,	PUNCT
admet-470	232	8	models	model	NOUN
admet-470	232	9	,	,	PUNCT
admet-470	232	10	facts	fact	NOUN
admet-470	232	11	and	and	CCONJ
admet-470	232	12	myths	myth	NOUN
admet-470	232	13	.	.	PUNCT
admet-470	233	1	mini	mini	ADJ
admet-470	233	2	reviews	review	NOUN
admet-470	233	3	in	in	ADP
admet-470	233	4	medicinal	medicinal	ADJ
admet-470	233	5	chemistry	chemistry	NOUN
admet-470	233	6	3	3	NUM
admet-470	233	7	(	(	PUNCT
admet-470	233	8	2003	2003	NUM
admet-470	233	9	)	)	PUNCT
admet-470	233	10	861	861	NUM
admet-470	233	11	-	-	SYM
admet-470	233	12	875	875	NUM
admet-470	233	13	.	.	PUNCT
admet-470	234	1	[	[	X
admet-470	234	2	6	6	NUM
admet-470	234	3	]	]	PUNCT
admet-470	234	4	f.	f.	PROPN
admet-470	234	5	lombardo	lombardo	PROPN
admet-470	234	6	,	,	PUNCT
admet-470	234	7	p.v	p.v	PROPN
admet-470	234	8	.	.	PROPN
admet-470	234	9	desai	desai	PROPN
admet-470	234	10	,	,	PUNCT
admet-470	234	11	r.	r.	PROPN
admet-470	234	12	arimoto	arimoto	PROPN
admet-470	234	13	,	,	PUNCT
admet-470	234	14	k.e	k.e	PROPN
admet-470	234	15	.	.	PROPN
admet-470	234	16	desino	desino	PROPN
admet-470	234	17	,	,	PUNCT
admet-470	234	18	h.	h.	PROPN
admet-470	234	19	fischer	fischer	PROPN
admet-470	234	20	,	,	PUNCT
admet-470	234	21	c.e	c.e	PROPN
admet-470	234	22	.	.	PROPN
admet-470	234	23	keefer	keefer	PROPN
admet-470	234	24	,	,	PUNCT
admet-470	234	25	c.	c.	PROPN
admet-470	234	26	petersson	petersson	PROPN
admet-470	234	27	,	,	PUNCT
admet-470	234	28	s.	s.	PROPN
admet-470	234	29	winiwarter	winiwarter	PROPN
admet-470	234	30	,	,	PUNCT
admet-470	234	31	f.	f.	PROPN
admet-470	234	32	broccatelli	broccatelli	PROPN
admet-470	234	33	.	.	PUNCT
admet-470	235	1	in	in	ADP
admet-470	235	2	silico	silico	NOUN
admet-470	235	3	absorption	absorption	NOUN
admet-470	235	4	,	,	PUNCT
admet-470	235	5	distribution	distribution	NOUN
admet-470	235	6	,	,	PUNCT
admet-470	235	7	metabolism	metabolism	NOUN
admet-470	235	8	,	,	PUNCT
admet-470	235	9	excretion	excretion	NOUN
admet-470	235	10	,	,	PUNCT
admet-470	235	11	and	and	CCONJ
admet-470	235	12	pharmacokinetics	pharmacokinetic	NOUN
admet-470	235	13	susanne	susanne	PROPN
admet-470	235	14	winiwarter	winiwarter	PROPN
admet-470	235	15	et	et	PROPN
admet-470	235	16	al	al	PROPN
admet-470	235	17	.	.	PROPN
admet-470	235	18	admet	admet	PROPN
admet-470	235	19	&	&	CCONJ
admet-470	235	20	dmpk	dmpk	PROPN
admet-470	235	21	6(1	6(1	NUM
admet-470	235	22	)	)	PUNCT
admet-470	235	23	(	(	PUNCT
admet-470	235	24	2018	2018	NUM
admet-470	235	25	)	)	PUNCT
admet-470	235	26	15	15	NUM
admet-470	235	27	-	-	SYM
admet-470	235	28	33	33	NUM
admet-470	235	29	32	32	NUM
admet-470	235	30	(	(	PUNCT
admet-470	235	31	adme	adme	NOUN
admet-470	235	32	-	-	PUNCT
admet-470	235	33	pk	pk	NOUN
admet-470	235	34	):	):	PUNCT
admet-470	235	35	utility	utility	NOUN
admet-470	235	36	and	and	CCONJ
admet-470	235	37	best	good	ADJ
admet-470	235	38	practices	practice	NOUN
admet-470	235	39	.	.	PUNCT
admet-470	236	1	an	an	DET
admet-470	236	2	industry	industry	NOUN
admet-470	236	3	perspective	perspective	NOUN
admet-470	236	4	from	from	ADP
admet-470	236	5	the	the	DET
admet-470	236	6	international	international	ADJ
admet-470	236	7	consortium	consortium	NOUN
admet-470	236	8	for	for	ADP
admet-470	236	9	innovation	innovation	NOUN
admet-470	236	10	through	through	ADP
admet-470	236	11	quality	quality	NOUN
admet-470	236	12	in	in	ADP
admet-470	236	13	pharmaceutical	pharmaceutical	ADJ
admet-470	236	14	development	development	NOUN
admet-470	236	15	.	.	PUNCT
admet-470	237	1	journal	journal	PROPN
admet-470	237	2	of	of	ADP
admet-470	237	3	medicinal	medicinal	ADJ
admet-470	237	4	chemistry	chemistry	NOUN
admet-470	237	5	60	60	NUM
admet-470	237	6	(	(	PUNCT
admet-470	237	7	2017	2017	NUM
admet-470	237	8	)	)	PUNCT
admet-470	237	9	9097	9097	NUM
admet-470	237	10	-	-	SYM
admet-470	237	11	9113	9113	NUM
admet-470	237	12	.	.	PUNCT
admet-470	238	1	[	[	X
admet-470	238	2	7	7	X
admet-470	238	3	]	]	X
admet-470	238	4	m.d	m.d	PROPN
admet-470	238	5	.	.	PROPN
admet-470	238	6	segall	segall	PROPN
admet-470	238	7	,	,	PUNCT
admet-470	238	8	a.p	a.p	PROPN
admet-470	238	9	.	.	PROPN
admet-470	238	10	beresford	beresford	PROPN
admet-470	238	11	,	,	PUNCT
admet-470	238	12	j.m.r	j.m.r	PROPN
admet-470	238	13	.	.	PROPN
admet-470	238	14	gola	gola	PROPN
admet-470	238	15	,	,	PUNCT
admet-470	238	16	d.	d.	PROPN
admet-470	238	17	hawksley	hawksley	PROPN
admet-470	238	18	,	,	PUNCT
admet-470	238	19	m.h	m.h	PROPN
admet-470	238	20	.	.	PROPN
admet-470	238	21	tarbit	tarbit	NOUN
admet-470	238	22	.	.	PUNCT
admet-470	239	1	focus	focus	NOUN
admet-470	239	2	on	on	ADP
admet-470	239	3	success	success	NOUN
admet-470	239	4	:	:	PUNCT
admet-470	239	5	using	use	VERB
admet-470	239	6	a	a	DET
admet-470	239	7	probabilistic	probabilistic	ADJ
admet-470	239	8	approach	approach	NOUN
admet-470	239	9	to	to	PART
admet-470	239	10	achieve	achieve	VERB
admet-470	239	11	an	an	DET
admet-470	239	12	optimal	optimal	ADJ
admet-470	239	13	balance	balance	NOUN
admet-470	239	14	of	of	ADP
admet-470	239	15	compound	compound	NOUN
admet-470	239	16	properties	property	NOUN
admet-470	239	17	in	in	ADP
admet-470	239	18	drug	drug	NOUN
admet-470	239	19	discovery	discovery	NOUN
admet-470	239	20	.	.	PUNCT
admet-470	240	1	expert	expert	ADJ
admet-470	240	2	opinion	opinion	NOUN
admet-470	240	3	on	on	ADP
admet-470	240	4	drug	drug	NOUN
admet-470	240	5	metabolism	metabolism	NOUN
admet-470	240	6	&	&	CCONJ
admet-470	240	7	toxicology	toxicology	NOUN
admet-470	240	8	2	2	NUM
admet-470	240	9	(	(	PUNCT
admet-470	240	10	2006	2006	NUM
admet-470	240	11	)	)	PUNCT
admet-470	240	12	325	325	NUM
admet-470	240	13	-	-	SYM
admet-470	240	14	337	337	NUM
admet-470	240	15	.	.	PUNCT
admet-470	241	1	[	[	X
admet-470	241	2	8	8	NUM
admet-470	241	3	]	]	X
admet-470	241	4	m.d	m.d	PROPN
admet-470	241	5	.	.	PROPN
admet-470	241	6	segall	segall	PROPN
admet-470	241	7	.	.	PUNCT
admet-470	242	1	multi	multi	ADJ
admet-470	242	2	-	-	ADJ
admet-470	242	3	parameter	parameter	ADJ
admet-470	242	4	optimization	optimization	NOUN
admet-470	242	5	:	:	PUNCT
admet-470	242	6	identifying	identify	VERB
admet-470	242	7	high	high	ADJ
admet-470	242	8	quality	quality	NOUN
admet-470	242	9	compounds	compound	NOUN
admet-470	242	10	with	with	ADP
admet-470	242	11	a	a	DET
admet-470	242	12	balance	balance	NOUN
admet-470	242	13	of	of	ADP
admet-470	242	14	properties	property	NOUN
admet-470	242	15	.	.	PUNCT
admet-470	243	1	current	current	ADJ
admet-470	243	2	pharmaceutical	pharmaceutical	NOUN
admet-470	243	3	design	design	NOUN
admet-470	243	4	18	18	NUM
admet-470	243	5	(	(	PUNCT
admet-470	243	6	2012	2012	NUM
admet-470	243	7	)	)	PUNCT
admet-470	243	8	1292	1292	NUM
admet-470	243	9	-	-	SYM
admet-470	243	10	1310	1310	NUM
admet-470	243	11	.	.	PUNCT
admet-470	244	1	[	[	X
admet-470	244	2	9	9	NUM
admet-470	244	3	]	]	X
admet-470	244	4	d.f	d.f	PROPN
admet-470	244	5	.	.	PROPN
admet-470	244	6	mcginnity	mcginnity	PROPN
admet-470	244	7	,	,	PUNCT
admet-470	244	8	j.	j.	PROPN
admet-470	244	9	collington	collington	PROPN
admet-470	244	10	,	,	PUNCT
admet-470	244	11	r.p	r.p	PROPN
admet-470	244	12	.	.	PROPN
admet-470	244	13	austin	austin	PROPN
admet-470	244	14	,	,	PUNCT
admet-470	244	15	r.j	r.j	PROPN
admet-470	244	16	.	.	PROPN
admet-470	244	17	riley	riley	PROPN
admet-470	244	18	.	.	PUNCT
admet-470	245	1	evaluation	evaluation	NOUN
admet-470	245	2	of	of	ADP
admet-470	245	3	human	human	ADJ
admet-470	245	4	pharmacokinetics	pharmacokinetic	NOUN
admet-470	245	5	,	,	PUNCT
admet-470	245	6	therapeutic	therapeutic	ADJ
admet-470	245	7	dose	dose	NOUN
admet-470	245	8	and	and	CCONJ
admet-470	245	9	exposure	exposure	NOUN
admet-470	245	10	predictions	prediction	NOUN
admet-470	245	11	using	use	VERB
admet-470	245	12	marketed	market	VERB
admet-470	245	13	oral	oral	ADJ
admet-470	245	14	drugs	drug	NOUN
admet-470	245	15	.	.	PUNCT
admet-470	246	1	current	current	ADJ
admet-470	246	2	drug	drug	NOUN
admet-470	246	3	metabolism	metabolism	NOUN
admet-470	246	4	8	8	NUM
admet-470	246	5	(	(	PUNCT
admet-470	246	6	2007	2007	NUM
admet-470	246	7	)	)	PUNCT
admet-470	246	8	463	463	NUM
admet-470	246	9	-	-	SYM
admet-470	246	10	479	479	NUM
admet-470	246	11	.	.	PUNCT
admet-470	247	1	[	[	X
admet-470	247	2	10	10	NUM
admet-470	247	3	]	]	X
admet-470	247	4	k.m	k.m	PROPN
admet-470	247	5	.	.	PROPN
admet-470	247	6	page	page	NOUN
admet-470	247	7	.	.	PUNCT
admet-470	248	1	validation	validation	NOUN
admet-470	248	2	of	of	ADP
admet-470	248	3	early	early	ADJ
admet-470	248	4	human	human	PROPN
admet-470	248	5	dose	dose	NOUN
admet-470	248	6	prediction	prediction	NOUN
admet-470	248	7	:	:	PUNCT
admet-470	248	8	a	a	DET
admet-470	248	9	key	key	ADJ
admet-470	248	10	metric	metric	NOUN
admet-470	248	11	for	for	ADP
admet-470	248	12	compound	compound	NOUN
admet-470	248	13	progression	progression	NOUN
admet-470	248	14	in	in	ADP
admet-470	248	15	drug	drug	NOUN
admet-470	248	16	discovery	discovery	NOUN
admet-470	248	17	.	.	PUNCT
admet-470	249	1	molecular	molecular	ADJ
admet-470	249	2	pharmaceutics	pharmaceutic	NOUN
admet-470	249	3	13	13	NUM
admet-470	249	4	(	(	PUNCT
admet-470	249	5	2016	2016	NUM
admet-470	249	6	)	)	PUNCT
admet-470	249	7	609	609	NUM
admet-470	249	8	-	-	SYM
admet-470	249	9	620	620	NUM
admet-470	249	10	.	.	PUNCT
admet-470	250	1	[	[	X
admet-470	250	2	11	11	NUM
admet-470	250	3	]	]	PUNCT
admet-470	250	4	m.	m.	NOUN
admet-470	250	5	lemurell	lemurell	PROPN
admet-470	250	6	,	,	PUNCT
admet-470	250	7	j.	j.	PROPN
admet-470	250	8	ulander	ulander	PROPN
admet-470	250	9	,	,	PUNCT
admet-470	250	10	s.	s.	PROPN
admet-470	250	11	winiwarter	winiwarter	PROPN
admet-470	250	12	,	,	PUNCT
admet-470	250	13	a.	a.	NOUN
admet-470	250	14	dahlen	dahlen	PROPN
admet-470	250	15	,	,	PUNCT
admet-470	250	16	o.	o.	PROPN
admet-470	250	17	davidsson	davidsson	PROPN
admet-470	250	18	,	,	PUNCT
admet-470	250	19	h.	h.	PROPN
admet-470	250	20	emtenas	emtenas	PROPN
admet-470	250	21	,	,	PUNCT
admet-470	250	22	j.	j.	PROPN
admet-470	250	23	broddefalk	broddefalk	PROPN
admet-470	250	24	,	,	PUNCT
admet-470	250	25	m.	m.	NOUN
admet-470	250	26	swanson	swanson	PROPN
admet-470	250	27	,	,	PUNCT
admet-470	250	28	d.	d.	PROPN
admet-470	250	29	hovdal	hovdal	PROPN
admet-470	250	30	,	,	PUNCT
admet-470	250	31	a.t	a.t	PROPN
admet-470	250	32	.	.	PROPN
admet-470	250	33	plowright	plowright	PROPN
admet-470	250	34	,	,	PUNCT
admet-470	250	35	a.	a.	NOUN
admet-470	250	36	pettersen	pettersen	NOUN
admet-470	250	37	,	,	PUNCT
admet-470	250	38	m.	m.	NOUN
admet-470	250	39	ryden	ryden	PROPN
admet-470	250	40	-	-	PUNCT
admet-470	250	41	landergren	landergren	PROPN
admet-470	250	42	,	,	PUNCT
admet-470	250	43	j.	j.	PROPN
admet-470	250	44	barlind	barlind	PROPN
admet-470	250	45	,	,	PUNCT
admet-470	250	46	a.	a.	NOUN
admet-470	250	47	llinas	llinas	PROPN
admet-470	250	48	,	,	PUNCT
admet-470	250	49	m.	m.	NOUN
admet-470	250	50	herslof	herslof	NOUN
admet-470	250	51	,	,	PUNCT
admet-470	250	52	t.	t.	PROPN
admet-470	250	53	drmota	drmota	PROPN
admet-470	250	54	,	,	PUNCT
admet-470	250	55	k.	k.	PROPN
admet-470	250	56	sigfridsson	sigfridsson	PROPN
admet-470	250	57	,	,	PUNCT
admet-470	250	58	s.	s.	PROPN
admet-470	250	59	moses	moses	PROPN
admet-470	250	60	,	,	PUNCT
admet-470	250	61	c.	c.	PROPN
admet-470	250	62	whatling	whatling	NOUN
admet-470	250	63	.	.	PUNCT
admet-470	251	1	discovery	discovery	NOUN
admet-470	251	2	of	of	ADP
admet-470	251	3	azd6642	azd6642	NOUN
admet-470	251	4	,	,	PUNCT
admet-470	251	5	an	an	DET
admet-470	251	6	inhibitor	inhibitor	NOUN
admet-470	251	7	of	of	ADP
admet-470	251	8	5lipoxygenase	5lipoxygenase	NUM
admet-470	251	9	activating	activate	VERB
admet-470	251	10	protein	protein	NOUN
admet-470	251	11	(	(	PUNCT
admet-470	251	12	flap	flap	NOUN
admet-470	251	13	)	)	PUNCT
admet-470	251	14	for	for	ADP
admet-470	251	15	the	the	DET
admet-470	251	16	treatment	treatment	NOUN
admet-470	251	17	of	of	ADP
admet-470	251	18	inflammatory	inflammatory	ADJ
admet-470	251	19	diseases	disease	NOUN
admet-470	251	20	.	.	PUNCT
admet-470	252	1	journal	journal	NOUN
admet-470	252	2	of	of	ADP
admet-470	252	3	medicinal	medicinal	ADJ
admet-470	252	4	chemistry	chemistry	NOUN
admet-470	252	5	58	58	NUM
admet-470	252	6	(	(	PUNCT
admet-470	252	7	2015	2015	NUM
admet-470	252	8	)	)	PUNCT
admet-470	252	9	897	897	NUM
admet-470	252	10	-	-	SYM
admet-470	252	11	911	911	NUM
admet-470	252	12	.	.	PUNCT
admet-470	253	1	[	[	X
admet-470	253	2	12	12	NUM
admet-470	253	3	]	]	X
admet-470	253	4	j.b	j.b	PROPN
admet-470	253	5	.	.	PROPN
admet-470	253	6	houston	houston	PROPN
admet-470	253	7	.	.	PUNCT
admet-470	254	1	utility	utility	NOUN
admet-470	254	2	of	of	ADP
admet-470	254	3	in	in	ADP
admet-470	254	4	vitro	vitro	X
admet-470	254	5	drug	drug	NOUN
admet-470	254	6	metabolism	metabolism	NOUN
admet-470	254	7	data	datum	NOUN
admet-470	254	8	in	in	ADP
admet-470	254	9	predicting	predict	VERB
admet-470	254	10	in	in	ADP
admet-470	254	11	vivo	vivo	ADJ
admet-470	254	12	metabolic	metabolic	NOUN
admet-470	254	13	clearance	clearance	NOUN
admet-470	254	14	.	.	PUNCT
admet-470	255	1	biochemical	biochemical	ADJ
admet-470	255	2	pharmacology	pharmacology	NOUN
admet-470	255	3	47	47	NUM
admet-470	255	4	(	(	PUNCT
admet-470	255	5	1994	1994	NUM
admet-470	255	6	)	)	PUNCT
admet-470	255	7	1469	1469	NUM
admet-470	255	8	-	-	SYM
admet-470	255	9	1479	1479	NUM
admet-470	255	10	.	.	PUNCT
admet-470	256	1	[	[	X
admet-470	256	2	13	13	NUM
admet-470	256	3	]	]	X
admet-470	256	4	l.z	l.z	PROPN
admet-470	256	5	.	.	PROPN
admet-470	256	6	benet	benet	PROPN
admet-470	256	7	,	,	PUNCT
admet-470	256	8	p.	p.	PROPN
admet-470	256	9	zia	zia	PROPN
admet-470	256	10	-	-	PUNCT
admet-470	256	11	amirhosseini	amirhosseini	NOUN
admet-470	256	12	.	.	PUNCT
admet-470	257	1	basic	basic	ADJ
admet-470	257	2	principles	principle	NOUN
admet-470	257	3	of	of	ADP
admet-470	257	4	pharmacokinetics	pharmacokinetic	NOUN
admet-470	257	5	.	.	PUNCT
admet-470	258	1	toxicologic	toxicologic	NOUN
admet-470	258	2	pathology	pathology	NOUN
admet-470	258	3	23	23	NUM
admet-470	258	4	(	(	PUNCT
admet-470	258	5	1995	1995	NUM
admet-470	258	6	)	)	PUNCT
admet-470	258	7	115	115	NUM
admet-470	258	8	-	-	SYM
admet-470	258	9	123	123	NUM
admet-470	258	10	.	.	PUNCT
admet-470	259	1	[	[	X
admet-470	259	2	14	14	NUM
admet-470	259	3	]	]	X
admet-470	259	4	l.	l.	PROPN
admet-470	259	5	fredlund	fredlund	PROPN
admet-470	259	6	,	,	PUNCT
admet-470	259	7	s.	s.	PROPN
admet-470	259	8	winiwarter	winiwarter	PROPN
admet-470	259	9	,	,	PUNCT
admet-470	259	10	c.	c.	PROPN
admet-470	259	11	hilgendorf	hilgendorf	PROPN
admet-470	259	12	.	.	PUNCT
admet-470	260	1	in	in	ADP
admet-470	260	2	vitro	vitro	X
admet-470	260	3	intrinsic	intrinsic	ADJ
admet-470	260	4	permeability	permeability	NOUN
admet-470	260	5	:	:	PUNCT
admet-470	260	6	a	a	DET
admet-470	260	7	transporter	transporter	NOUN
admet-470	260	8	-	-	PUNCT
admet-470	260	9	independent	independent	ADJ
admet-470	260	10	measure	measure	NOUN
admet-470	260	11	of	of	ADP
admet-470	260	12	caco-2	caco-2	NUM
admet-470	260	13	cell	cell	NOUN
admet-470	260	14	permeability	permeability	NOUN
admet-470	260	15	in	in	ADP
admet-470	260	16	drug	drug	NOUN
admet-470	260	17	design	design	NOUN
admet-470	260	18	and	and	CCONJ
admet-470	260	19	development	development	NOUN
admet-470	260	20	.	.	PUNCT
admet-470	261	1	molecular	molecular	ADJ
admet-470	261	2	pharmaceutics	pharmaceutic	NOUN
admet-470	261	3	14	14	NUM
admet-470	261	4	(	(	PUNCT
admet-470	261	5	2017	2017	NUM
admet-470	261	6	)	)	PUNCT
admet-470	261	7	1601	1601	NUM
admet-470	261	8	-	-	SYM
admet-470	261	9	1609	1609	NUM
admet-470	261	10	.	.	PUNCT
admet-470	262	1	[	[	X
admet-470	262	2	15	15	NUM
admet-470	262	3	]	]	X
admet-470	262	4	a.-k	a.-k	NOUN
admet-470	262	5	.	.	PUNCT
admet-470	263	1	sohlenius	sohlenius	PROPN
admet-470	263	2	-	-	PUNCT
admet-470	263	3	sternbeck	sternbeck	PROPN
admet-470	263	4	,	,	PUNCT
admet-470	263	5	c.	c.	PROPN
admet-470	263	6	jones	jones	PROPN
admet-470	263	7	,	,	PUNCT
admet-470	263	8	d.	d.	PROPN
admet-470	263	9	ferguson	ferguson	PROPN
admet-470	263	10	,	,	PUNCT
admet-470	263	11	b.j	b.j	PROPN
admet-470	263	12	.	.	PROPN
admet-470	263	13	middleton	middleton	PROPN
admet-470	263	14	,	,	PUNCT
admet-470	263	15	d.	d.	PROPN
admet-470	263	16	projean	projean	PROPN
admet-470	263	17	,	,	PUNCT
admet-470	263	18	e.	e.	PROPN
admet-470	263	19	floby	floby	PROPN
admet-470	263	20	,	,	PUNCT
admet-470	263	21	j.	j.	PROPN
admet-470	263	22	bylund	bylund	PROPN
admet-470	263	23	,	,	PUNCT
admet-470	263	24	l.	l.	PROPN
admet-470	263	25	afzelius	afzelius	PROPN
admet-470	263	26	.	.	PUNCT
admet-470	264	1	practical	practical	ADJ
admet-470	264	2	use	use	NOUN
admet-470	264	3	of	of	ADP
admet-470	264	4	the	the	DET
admet-470	264	5	regression	regression	NOUN
admet-470	264	6	offset	offset	VERB
admet-470	264	7	approach	approach	NOUN
admet-470	264	8	for	for	ADP
admet-470	264	9	the	the	DET
admet-470	264	10	prediction	prediction	NOUN
admet-470	264	11	of	of	ADP
admet-470	264	12	in	in	ADP
admet-470	264	13	vivo	vivo	ADJ
admet-470	264	14	intrinsic	intrinsic	ADJ
admet-470	264	15	clearance	clearance	NOUN
admet-470	264	16	from	from	ADP
admet-470	264	17	hepatocytes	hepatocytes	PROPN
admet-470	264	18	.	.	PUNCT
admet-470	265	1	xenobiotica	xenobiotica	PROPN
admet-470	265	2	42	42	NUM
admet-470	265	3	(	(	PUNCT
admet-470	265	4	2012	2012	NUM
admet-470	265	5	)	)	PUNCT
admet-470	265	6	841	841	NUM
admet-470	265	7	-	-	SYM
admet-470	265	8	853	853	NUM
admet-470	265	9	.	.	PUNCT
admet-470	266	1	[	[	X
admet-470	266	2	16	16	NUM
admet-470	266	3	]	]	X
admet-470	266	4	m.p	m.p	PROPN
admet-470	266	5	.	.	PROPN
admet-470	266	6	gleeson	gleeson	PROPN
admet-470	266	7	,	,	PUNCT
admet-470	266	8	a.	a.	PROPN
admet-470	266	9	hersey	hersey	PROPN
admet-470	266	10	,	,	PUNCT
admet-470	266	11	s.	s.	PROPN
admet-470	266	12	hannongbua	hannongbua	PROPN
admet-470	266	13	.	.	PUNCT
admet-470	267	1	in	in	ADP
admet-470	267	2	-	-	PUNCT
admet-470	267	3	silico	silico	NOUN
admet-470	267	4	adme	adme	NOUN
admet-470	267	5	models	model	NOUN
admet-470	267	6	:	:	PUNCT
admet-470	267	7	a	a	DET
admet-470	267	8	general	general	ADJ
admet-470	267	9	assessment	assessment	NOUN
admet-470	267	10	of	of	ADP
admet-470	267	11	their	their	PRON
admet-470	267	12	utility	utility	NOUN
admet-470	267	13	in	in	ADP
admet-470	267	14	drug	drug	NOUN
admet-470	267	15	discovery	discovery	NOUN
admet-470	267	16	applications	application	NOUN
admet-470	267	17	.	.	PUNCT
admet-470	268	1	current	current	ADJ
admet-470	268	2	topics	topic	NOUN
admet-470	268	3	in	in	ADP
admet-470	268	4	medicinal	medicinal	ADJ
admet-470	268	5	chemistry	chemistry	NOUN
admet-470	268	6	11	11	NUM
admet-470	268	7	(	(	PUNCT
admet-470	268	8	2011	2011	NUM
admet-470	268	9	)	)	PUNCT
admet-470	268	10	358	358	NUM
admet-470	268	11	-	-	SYM
admet-470	268	12	381	381	NUM
admet-470	268	13	.	.	PUNCT
admet-470	269	1	[	[	X
admet-470	269	2	17	17	NUM
admet-470	269	3	]	]	X
admet-470	269	4	r.s	r.s	PROPN
admet-470	269	5	.	.	PROPN
admet-470	269	6	obach	obach	PROPN
admet-470	269	7	,	,	PUNCT
admet-470	269	8	f.	f.	PROPN
admet-470	269	9	lombardo	lombardo	PROPN
admet-470	269	10	,	,	PUNCT
admet-470	269	11	n.j	n.j	PROPN
admet-470	269	12	.	.	PROPN
admet-470	269	13	waters	water	NOUN
admet-470	269	14	.	.	PUNCT
admet-470	270	1	trend	trend	NOUN
admet-470	270	2	analysis	analysis	NOUN
admet-470	270	3	of	of	ADP
admet-470	270	4	a	a	DET
admet-470	270	5	database	database	NOUN
admet-470	270	6	of	of	ADP
admet-470	270	7	intravenous	intravenous	ADJ
admet-470	270	8	pharmacokinetic	pharmacokinetic	ADJ
admet-470	270	9	parameters	parameter	NOUN
admet-470	270	10	in	in	ADP
admet-470	270	11	humans	human	NOUN
admet-470	270	12	for	for	ADP
admet-470	270	13	670	670	NUM
admet-470	270	14	drug	drug	NOUN
admet-470	270	15	compounds	compound	NOUN
admet-470	270	16	.	.	PUNCT
admet-470	271	1	drug	drug	NOUN
admet-470	271	2	metabolism	metabolism	NOUN
admet-470	271	3	and	and	CCONJ
admet-470	271	4	disposition	disposition	NOUN
admet-470	271	5	36	36	NUM
admet-470	271	6	(	(	PUNCT
admet-470	271	7	2008	2008	NUM
admet-470	271	8	)	)	PUNCT
admet-470	271	9	13851405	13851405	NUM
admet-470	271	10	.	.	PUNCT
admet-470	272	1	[	[	X
admet-470	272	2	18	18	NUM
admet-470	272	3	]	]	X
admet-470	272	4	l.s	l.s	PROPN
admet-470	272	5	.	.	PROPN
admet-470	272	6	goodman	goodman	PROPN
admet-470	272	7	,	,	PUNCT
admet-470	272	8	a.g	a.g	PROPN
admet-470	272	9	.	.	PROPN
admet-470	272	10	gilman	gilman	PROPN
admet-470	272	11	,	,	PUNCT
admet-470	272	12	the	the	DET
admet-470	272	13	pharmacological	pharmacological	ADJ
admet-470	272	14	basis	basis	NOUN
admet-470	272	15	of	of	ADP
admet-470	272	16	therapeutics	therapeutic	NOUN
admet-470	272	17	,	,	PUNCT
admet-470	272	18	9th	9th	ADJ
admet-470	272	19	ed	ed	NOUN
admet-470	272	20	.	.	PROPN
admet-470	272	21	,	,	PUNCT
admet-470	272	22	mcgraw	mcgraw	PROPN
admet-470	272	23	-	-	PUNCT
admet-470	272	24	hill	hill	NOUN
admet-470	272	25	publishers	publisher	NOUN
admet-470	272	26	:	:	PUNCT
admet-470	272	27	new	new	PROPN
admet-470	272	28	york	york	PROPN
admet-470	272	29	,	,	PUNCT
admet-470	272	30	1996	1996	NUM
admet-470	272	31	.	.	PUNCT
admet-470	273	1	[	[	X
admet-470	273	2	19	19	NUM
admet-470	273	3	]	]	X
admet-470	273	4	v.	v.	CCONJ
admet-470	273	5	svetnik	svetnik	PROPN
admet-470	273	6	,	,	PUNCT
admet-470	273	7	a.	a.	PROPN
admet-470	273	8	liaw	liaw	PROPN
admet-470	273	9	,	,	PUNCT
admet-470	273	10	c.	c.	PROPN
admet-470	273	11	tong	tong	PROPN
admet-470	273	12	,	,	PUNCT
admet-470	273	13	j.c	j.c	PROPN
admet-470	273	14	.	.	PROPN
admet-470	273	15	culberson	culberson	PROPN
admet-470	273	16	,	,	PUNCT
admet-470	273	17	r.p	r.p	PROPN
admet-470	273	18	.	.	PROPN
admet-470	273	19	sheridan	sheridan	PROPN
admet-470	273	20	,	,	PUNCT
admet-470	273	21	b.p	b.p	PROPN
admet-470	273	22	.	.	PROPN
admet-470	273	23	feuston	feuston	NOUN
admet-470	273	24	.	.	PUNCT
admet-470	274	1	random	random	ADJ
admet-470	274	2	forest	forest	NOUN
admet-470	274	3	:	:	PUNCT
admet-470	274	4	a	a	DET
admet-470	274	5	classification	classification	NOUN
admet-470	274	6	and	and	CCONJ
admet-470	274	7	regression	regression	NOUN
admet-470	274	8	tool	tool	NOUN
admet-470	274	9	for	for	ADP
admet-470	274	10	compound	compound	NOUN
admet-470	274	11	classification	classification	NOUN
admet-470	274	12	and	and	CCONJ
admet-470	274	13	qsar	qsar	NOUN
admet-470	274	14	modeling	modeling	NOUN
admet-470	274	15	.	.	PUNCT
admet-470	275	1	journal	journal	PROPN
admet-470	275	2	of	of	ADP
admet-470	275	3	chemical	chemical	ADJ
admet-470	275	4	information	information	NOUN
admet-470	275	5	and	and	CCONJ
admet-470	275	6	computer	computer	NOUN
admet-470	275	7	sciences	science	NOUN
admet-470	275	8	43	43	NUM
admet-470	275	9	(	(	PUNCT
admet-470	275	10	2003	2003	NUM
admet-470	275	11	)	)	PUNCT
admet-470	275	12	1947	1947	NUM
admet-470	275	13	-	-	SYM
admet-470	275	14	1958	1958	NUM
admet-470	275	15	.	.	PUNCT
admet-470	276	1	[	[	X
admet-470	276	2	20	20	NUM
admet-470	276	3	]	]	PUNCT
admet-470	276	4	p.	p.	NOUN
admet-470	276	5	bruneau	bruneau	PROPN
admet-470	276	6	.	.	PUNCT
admet-470	277	1	search	search	NOUN
admet-470	277	2	for	for	ADP
admet-470	277	3	predictive	predictive	ADJ
admet-470	277	4	generic	generic	ADJ
admet-470	277	5	model	model	NOUN
admet-470	277	6	of	of	ADP
admet-470	277	7	aqueous	aqueous	ADJ
admet-470	277	8	solubility	solubility	NOUN
admet-470	277	9	using	use	VERB
admet-470	277	10	bayesian	bayesian	NOUN
admet-470	277	11	neural	neural	ADJ
admet-470	277	12	nets	net	NOUN
admet-470	277	13	.	.	PUNCT
admet-470	278	1	journal	journal	NOUN
admet-470	278	2	of	of	ADP
admet-470	278	3	chemical	chemical	ADJ
admet-470	278	4	information	information	NOUN
admet-470	278	5	and	and	CCONJ
admet-470	278	6	computer	computer	NOUN
admet-470	278	7	sciences	science	NOUN
admet-470	278	8	41	41	NUM
admet-470	278	9	(	(	PUNCT
admet-470	278	10	2001	2001	NUM
admet-470	278	11	)	)	PUNCT
admet-470	278	12	1605	1605	NUM
admet-470	278	13	-	-	SYM
admet-470	278	14	1616	1616	NUM
admet-470	278	15	.	.	PUNCT
admet-470	279	1	[	[	X
admet-470	279	2	21	21	NUM
admet-470	279	3	]	]	X
admet-470	279	4	acd	acd	PROPN
admet-470	279	5	/	/	SYM
admet-470	279	6	labs	labs	PROPN
admet-470	279	7	software	software	NOUN
admet-470	279	8	,	,	PUNCT
admet-470	279	9	2015	2015	NUM
admet-470	279	10	,	,	PUNCT
admet-470	279	11	advanced	advanced	ADJ
admet-470	279	12	chemistry	chemistry	NOUN
admet-470	279	13	development	development	PROPN
admet-470	279	14	,	,	PUNCT
admet-470	279	15	inc	inc	PROPN
admet-470	279	16	.	.	PROPN
admet-470	279	17	,	,	PUNCT
admet-470	279	18	toronto	toronto	PROPN
admet-470	279	19	,	,	PUNCT
admet-470	279	20	ontario	ontario	PROPN
admet-470	279	21	,	,	PUNCT
admet-470	279	22	canada	canada	PROPN
admet-470	279	23	.	.	PUNCT
admet-470	280	1	[	[	X
admet-470	280	2	22	22	NUM
admet-470	280	3	]	]	X
admet-470	280	4	clogp	clogp	NOUN
admet-470	280	5	,	,	PUNCT
admet-470	280	6	4.3	4.3	NUM
admet-470	280	7	,	,	PUNCT
admet-470	280	8	pomona	pomona	PROPN
admet-470	280	9	college	college	PROPN
admet-470	280	10	and	and	CCONJ
admet-470	280	11	biobyte	biobyte	PROPN
admet-470	280	12	,	,	PUNCT
admet-470	280	13	inc	inc	PROPN
admet-470	280	14	.	.	PROPN
admet-470	280	15	,	,	PUNCT
admet-470	280	16	claremont	claremont	PROPN
admet-470	280	17	,	,	PUNCT
admet-470	280	18	ca	can	AUX
admet-470	280	19	,	,	PUNCT
admet-470	280	20	us	we	PRON
admet-470	280	21	.	.	PUNCT
admet-470	281	1	[	[	X
admet-470	281	2	23	23	NUM
admet-470	281	3	]	]	X
admet-470	281	4	f.	f.	PROPN
admet-470	281	5	pedregosa	pedregosa	PROPN
admet-470	281	6	,	,	PUNCT
admet-470	281	7	g.	g.	PROPN
admet-470	281	8	varoquaux	varoquaux	PROPN
admet-470	281	9	,	,	PUNCT
admet-470	281	10	a.	a.	NOUN
admet-470	281	11	gramfort	gramfort	NOUN
admet-470	281	12	,	,	PUNCT
admet-470	281	13	v.	v.	PROPN
admet-470	281	14	michel	michel	PROPN
admet-470	281	15	,	,	PUNCT
admet-470	281	16	b.	b.	PROPN
admet-470	281	17	thirion	thirion	PROPN
admet-470	281	18	,	,	PUNCT
admet-470	281	19	o.	o.	PROPN
admet-470	281	20	grisel	grisel	PROPN
admet-470	281	21	,	,	PUNCT
admet-470	281	22	m.	m.	NOUN
admet-470	281	23	blondel	blondel	PROPN
admet-470	281	24	,	,	PUNCT
admet-470	281	25	p.	p.	NOUN
admet-470	281	26	prettenhofer	prettenhofer	NOUN
admet-470	281	27	,	,	PUNCT
admet-470	281	28	r.	r.	PROPN
admet-470	281	29	weiss	weiss	PROPN
admet-470	281	30	,	,	PUNCT
admet-470	281	31	v.	v.	ADP
admet-470	281	32	dubourg	dubourg	PROPN
admet-470	281	33	,	,	PUNCT
admet-470	281	34	j.	j.	PROPN
admet-470	281	35	vanderplas	vanderplas	PROPN
admet-470	281	36	,	,	PUNCT
admet-470	281	37	a.	a.	NOUN
admet-470	281	38	passos	passos	PROPN
admet-470	281	39	,	,	PUNCT
admet-470	281	40	d.	d.	PROPN
admet-470	281	41	cournapeau	cournapeau	PROPN
admet-470	281	42	,	,	PUNCT
admet-470	281	43	m.	m.	NOUN
admet-470	281	44	brucher	brucher	ADJ
admet-470	281	45	,	,	PUNCT
admet-470	281	46	m.	m.	NOUN
admet-470	281	47	perrot	perrot	PROPN
admet-470	281	48	,	,	PUNCT
admet-470	281	49	é	é	PROPN
admet-470	281	50	.	.	PUNCT
admet-470	281	51	duchesnay	duchesnay	PROPN
admet-470	281	52	.	.	PUNCT
admet-470	282	1	scikit	scikit	NOUN
admet-470	282	2	-	-	PUNCT
admet-470	282	3	learn	learn	VERB
admet-470	282	4	:	:	PUNCT
admet-470	282	5	machine	machine	NOUN
admet-470	282	6	learning	learning	NOUN
admet-470	282	7	in	in	ADP
admet-470	282	8	python	python	PROPN
admet-470	282	9	.	.	PUNCT
admet-470	283	1	journal	journal	PROPN
admet-470	283	2	of	of	ADP
admet-470	283	3	machine	machine	NOUN
admet-470	283	4	learning	learn	VERB
admet-470	283	5	research	research	NOUN
admet-470	283	6	12	12	NUM
admet-470	283	7	(	(	PUNCT
admet-470	283	8	2011	2011	NUM
admet-470	283	9	)	)	PUNCT
admet-470	283	10	2825	2825	NUM
admet-470	283	11	-	-	SYM
admet-470	283	12	2830	2830	NUM
admet-470	283	13	.	.	PUNCT
admet-470	284	1	[	[	X
admet-470	284	2	24	24	NUM
admet-470	284	3	]	]	X
admet-470	284	4	h.	h.	PROPN
admet-470	284	5	wan	wan	PROPN
admet-470	284	6	,	,	PUNCT
admet-470	284	7	f.	f.	PROPN
admet-470	284	8	bergström	bergström	PROPN
admet-470	284	9	.	.	PUNCT
admet-470	285	1	high	high	ADJ
admet-470	285	2	throughput	throughput	NOUN
admet-470	285	3	screening	screening	NOUN
admet-470	285	4	of	of	ADP
admet-470	285	5	drug	drug	NOUN
admet-470	285	6	protein	protein	NOUN
admet-470	285	7	binding	bind	VERB
admet-470	285	8	in	in	ADP
admet-470	285	9	drug	drug	NOUN
admet-470	285	10	discovery	discovery	NOUN
admet-470	285	11	.	.	PUNCT
admet-470	286	1	journal	journal	NOUN
admet-470	286	2	of	of	ADP
admet-470	286	3	liquid	liquid	ADJ
admet-470	286	4	chromatography	chromatography	NOUN
admet-470	286	5	&	&	CCONJ
admet-470	286	6	related	relate	VERB
admet-470	286	7	techniques	technique	NOUN
admet-470	286	8	30	30	NUM
admet-470	286	9	(	(	PUNCT
admet-470	286	10	2007	2007	NUM
admet-470	286	11	)	)	PUNCT
admet-470	286	12	681	681	NUM
admet-470	286	13	-	-	SYM
admet-470	286	14	700	700	NUM
admet-470	286	15	.	.	PUNCT
admet-470	287	1	admet	admet	PROPN
admet-470	287	2	&	&	CCONJ
admet-470	287	3	dmpk	dmpk	PROPN
admet-470	287	4	6(1	6(1	NUM
admet-470	287	5	)	)	PUNCT
admet-470	287	6	(	(	PUNCT
admet-470	287	7	2018	2018	NUM
admet-470	287	8	)	)	PUNCT
admet-470	287	9	15	15	NUM
admet-470	287	10	-	-	SYM
admet-470	287	11	33	33	NUM
admet-470	287	12	in	in	ADP
admet-470	287	13	silico	silico	NOUN
admet-470	287	14	adme	adme	NOUN
admet-470	287	15	in	in	ADP
admet-470	287	16	drug	drug	NOUN
admet-470	287	17	design	design	NOUN
admet-470	287	18	doi	doi	NOUN
admet-470	287	19	:	:	PUNCT
admet-470	287	20	10.5599	10.5599	NUM
admet-470	287	21	/	/	SYM
admet-470	287	22	admet.6.1.470	admet.6.1.470	X
admet-470	287	23	33	33	NUM
admet-470	288	1	[	[	X
admet-470	288	2	25	25	NUM
admet-470	288	3	]	]	X
admet-470	288	4	n.j	n.j	PROPN
admet-470	288	5	.	.	PROPN
admet-470	288	6	waters	waters	PROPN
admet-470	288	7	,	,	PUNCT
admet-470	288	8	r.	r.	PROPN
admet-470	288	9	jones	jones	PROPN
admet-470	288	10	,	,	PUNCT
admet-470	288	11	g.	g.	PROPN
admet-470	288	12	williams	williams	PROPN
admet-470	288	13	,	,	PUNCT
admet-470	288	14	b.	b.	PROPN
admet-470	288	15	sohal	sohal	NOUN
admet-470	288	16	.	.	PUNCT
admet-470	289	1	validation	validation	NOUN
admet-470	289	2	of	of	ADP
admet-470	289	3	a	a	DET
admet-470	289	4	rapid	rapid	ADJ
admet-470	289	5	equilibrium	equilibrium	NOUN
admet-470	289	6	dialysis	dialysis	NOUN
admet-470	289	7	approach	approach	NOUN
admet-470	289	8	for	for	ADP
admet-470	289	9	the	the	DET
admet-470	289	10	measurement	measurement	NOUN
admet-470	289	11	of	of	ADP
admet-470	289	12	plasma	plasma	NOUN
admet-470	289	13	protein	protein	NOUN
admet-470	289	14	binding	bind	VERB
admet-470	289	15	.	.	PUNCT
admet-470	290	1	journal	journal	NOUN
admet-470	290	2	of	of	ADP
admet-470	290	3	pharmaceutical	pharmaceutical	PROPN
admet-470	290	4	sciences	science	NOUN
admet-470	290	5	97	97	NUM
admet-470	290	6	(	(	PUNCT
admet-470	290	7	2008	2008	NUM
admet-470	290	8	)	)	PUNCT
admet-470	290	9	4586	4586	NUM
admet-470	290	10	.	.	PUNCT
admet-470	291	1	[	[	X
admet-470	291	2	26	26	NUM
admet-470	291	3	]	]	X
admet-470	291	4	m.c	m.c	PROPN
admet-470	291	5	.	.	PROPN
admet-470	291	6	wenlock	wenlock	PROPN
admet-470	291	7	,	,	PUNCT
admet-470	291	8	l.a	l.a	PROPN
admet-470	291	9	.	.	PROPN
admet-470	291	10	carlsson	carlsson	PROPN
admet-470	291	11	.	.	PUNCT
admet-470	292	1	how	how	SCONJ
admet-470	292	2	experimental	experimental	ADJ
admet-470	292	3	errors	error	NOUN
admet-470	292	4	influence	influence	VERB
admet-470	292	5	drug	drug	NOUN
admet-470	292	6	metabolism	metabolism	NOUN
admet-470	292	7	and	and	CCONJ
admet-470	292	8	pharmacokinetic	pharmacokinetic	ADJ
admet-470	292	9	qsar	qsar	NOUN
admet-470	292	10	/	/	SYM
admet-470	292	11	qspr	qspr	NOUN
admet-470	292	12	models	model	NOUN
admet-470	292	13	.	.	PUNCT
admet-470	293	1	journal	journal	NOUN
admet-470	293	2	of	of	ADP
admet-470	293	3	chemical	chemical	ADJ
admet-470	293	4	information	information	NOUN
admet-470	293	5	and	and	CCONJ
admet-470	293	6	modeling	model	VERB
admet-470	293	7	55	55	NUM
admet-470	293	8	(	(	PUNCT
admet-470	293	9	2015	2015	NUM
admet-470	293	10	)	)	PUNCT
admet-470	293	11	125134	125134	NUM
admet-470	293	12	.	.	PUNCT
admet-470	294	1	[	[	X
admet-470	294	2	27	27	NUM
admet-470	294	3	]	]	X
admet-470	294	4	n.	n.	PROPN
admet-470	294	5	cristianini	cristianini	PROPN
admet-470	294	6	,	,	PUNCT
admet-470	294	7	j.	j.	PROPN
admet-470	294	8	shawe	shawe	PROPN
admet-470	294	9	-	-	PUNCT
admet-470	294	10	taylor	taylor	PROPN
admet-470	294	11	,	,	PUNCT
admet-470	294	12	an	an	DET
admet-470	294	13	introduction	introduction	NOUN
admet-470	294	14	to	to	PART
admet-470	294	15	support	support	VERB
admet-470	294	16	vector	vector	NOUN
admet-470	294	17	machines	machine	NOUN
admet-470	294	18	:	:	PUNCT
admet-470	294	19	and	and	CCONJ
admet-470	294	20	other	other	ADJ
admet-470	294	21	kernel	kernel	NOUN
admet-470	294	22	-	-	PUNCT
admet-470	294	23	based	base	VERB
admet-470	294	24	learning	learning	NOUN
admet-470	294	25	methods	method	NOUN
admet-470	294	26	,	,	PUNCT
admet-470	294	27	university	university	NOUN
admet-470	294	28	press	press	NOUN
admet-470	294	29	,	,	PUNCT
admet-470	294	30	cambridge	cambridge	PROPN
admet-470	294	31	,	,	PUNCT
admet-470	294	32	2000	2000	NUM
admet-470	294	33	.	.	PUNCT
admet-470	295	1	[	[	X
admet-470	295	2	28	28	NUM
admet-470	295	3	]	]	X
admet-470	295	4	j.l	j.l	PROPN
admet-470	295	5	.	.	PROPN
admet-470	295	6	faulon	faulon	PROPN
admet-470	295	7	,	,	PUNCT
admet-470	295	8	d.p	d.p	PROPN
admet-470	295	9	.	.	PROPN
admet-470	295	10	visco	visco	PROPN
admet-470	295	11	,	,	PUNCT
admet-470	295	12	jr	jr	PROPN
admet-470	295	13	.	.	PROPN
admet-470	295	14	,	,	PUNCT
admet-470	295	15	r.s	r.s	PROPN
admet-470	295	16	.	.	PROPN
admet-470	295	17	pophale	pophale	PROPN
admet-470	295	18	.	.	PUNCT
admet-470	296	1	the	the	DET
admet-470	296	2	signature	signature	NOUN
admet-470	296	3	molecular	molecular	ADJ
admet-470	296	4	descriptor	descriptor	NOUN
admet-470	296	5	.	.	PUNCT
admet-470	297	1	1	1	X
admet-470	297	2	.	.	X
admet-470	297	3	using	use	VERB
admet-470	297	4	extended	extended	ADJ
admet-470	297	5	valence	valence	NOUN
admet-470	297	6	sequences	sequence	NOUN
admet-470	297	7	in	in	ADP
admet-470	297	8	qsar	qsar	NOUN
admet-470	297	9	and	and	CCONJ
admet-470	297	10	qspr	qspr	NOUN
admet-470	297	11	studies	study	NOUN
admet-470	297	12	.	.	PUNCT
admet-470	298	1	journal	journal	PROPN
admet-470	298	2	of	of	ADP
admet-470	298	3	chemical	chemical	ADJ
admet-470	298	4	information	information	NOUN
admet-470	298	5	and	and	CCONJ
admet-470	298	6	computer	computer	NOUN
admet-470	298	7	sciences	science	NOUN
admet-470	298	8	43	43	NUM
admet-470	298	9	(	(	PUNCT
admet-470	298	10	2003	2003	NUM
admet-470	298	11	)	)	PUNCT
admet-470	298	12	707	707	NUM
admet-470	298	13	-	-	SYM
admet-470	298	14	720	720	NUM
admet-470	298	15	.	.	PUNCT
admet-470	299	1	[	[	X
admet-470	299	2	29	29	NUM
admet-470	299	3	]	]	X
admet-470	299	4	v.	v.	CCONJ
admet-470	299	5	vovk	vovk	ADJ
admet-470	299	6	,	,	PUNCT
admet-470	299	7	a.	a.	NOUN
admet-470	299	8	gammerman	gammerman	PROPN
admet-470	299	9	,	,	PUNCT
admet-470	299	10	g.	g.	PROPN
admet-470	299	11	shafer	shafer	PROPN
admet-470	299	12	,	,	PUNCT
admet-470	299	13	algorithmic	algorithmic	ADJ
admet-470	299	14	learning	learning	NOUN
admet-470	299	15	in	in	ADP
admet-470	299	16	a	a	DET
admet-470	299	17	random	random	ADJ
admet-470	299	18	world	world	NOUN
admet-470	299	19	,	,	PUNCT
admet-470	299	20	springer	springer	NOUN
admet-470	299	21	,	,	PUNCT
admet-470	299	22	new	new	PROPN
admet-470	299	23	york	york	PROPN
admet-470	299	24	,	,	PUNCT
admet-470	299	25	2005	2005	NUM
admet-470	299	26	.	.	PUNCT
admet-470	300	1	[	[	X
admet-470	300	2	30	30	NUM
admet-470	300	3	]	]	X
admet-470	300	4	genettasoft	genettasoft	NOUN
admet-470	300	5	,	,	PUNCT
admet-470	300	6	http://www.genettasoft.com/	http://www.genettasoft.com/	NOUN
admet-470	300	7	(	(	PUNCT
admet-470	300	8	2017	2017	NUM
admet-470	300	9	-	-	SYM
admet-470	300	10	10	10	NUM
admet-470	300	11	-	-	NUM
admet-470	300	12	25	25	NUM
admet-470	300	13	)	)	PUNCT
admet-470	300	14	.	.	PUNCT
admet-470	301	1	[	[	X
admet-470	301	2	31	31	NUM
admet-470	301	3	]	]	PUNCT
admet-470	301	4	a.-k	a.-k	PROPN
admet-470	301	5	.	.	PUNCT
admet-470	302	1	sohlenius	sohlenius	PROPN
admet-470	302	2	-	-	PUNCT
admet-470	302	3	sternbeck	sternbeck	PROPN
admet-470	302	4	,	,	PUNCT
admet-470	302	5	l.	l.	PROPN
admet-470	302	6	afzelius	afzelius	PROPN
admet-470	302	7	,	,	PUNCT
admet-470	302	8	p.	p.	NOUN
admet-470	302	9	prusis	prusis	NOUN
admet-470	302	10	,	,	PUNCT
admet-470	302	11	j.	j.	PROPN
admet-470	302	12	neelissen	neelissen	PROPN
admet-470	302	13	,	,	PUNCT
admet-470	302	14	j.	j.	PROPN
admet-470	302	15	hogstraate	hogstraate	PROPN
admet-470	302	16	,	,	PUNCT
admet-470	302	17	j.	j.	PROPN
admet-470	302	18	johansson	johansson	PROPN
admet-470	302	19	,	,	PUNCT
admet-470	302	20	e.	e.	PROPN
admet-470	302	21	floby	floby	PROPN
admet-470	302	22	,	,	PUNCT
admet-470	302	23	a.	a.	PROPN
admet-470	302	24	bengtsson	bengtsson	PROPN
admet-470	302	25	,	,	PUNCT
admet-470	302	26	o.	o.	PROPN
admet-470	302	27	gissberg	gissberg	PROPN
admet-470	302	28	,	,	PUNCT
admet-470	302	29	j.	j.	PROPN
admet-470	302	30	sternbeck	sternbeck	PROPN
admet-470	302	31	,	,	PUNCT
admet-470	302	32	c.	c.	PROPN
admet-470	302	33	petersson	petersson	PROPN
admet-470	302	34	.	.	PUNCT
admet-470	303	1	evaluation	evaluation	NOUN
admet-470	303	2	of	of	ADP
admet-470	303	3	the	the	DET
admet-470	303	4	human	human	ADJ
admet-470	303	5	prediction	prediction	NOUN
admet-470	303	6	of	of	ADP
admet-470	303	7	clearance	clearance	NOUN
admet-470	303	8	from	from	ADP
admet-470	303	9	hepatocytes	hepatocyte	NOUN
admet-470	303	10	and	and	CCONJ
admet-470	303	11	microsome	microsome	VERB
admet-470	303	12	intrinsic	intrinsic	ADJ
admet-470	303	13	clearance	clearance	NOUN
admet-470	303	14	for	for	ADP
admet-470	303	15	52	52	NUM
admet-470	303	16	drug	drug	NOUN
admet-470	303	17	compounds	compound	NOUN
admet-470	303	18	.	.	PUNCT
admet-470	304	1	xenobiotica	xenobiotica	PROPN
admet-470	304	2	40	40	NUM
admet-470	304	3	(	(	PUNCT
admet-470	304	4	2010	2010	NUM
admet-470	304	5	)	)	PUNCT
admet-470	304	6	637	637	NUM
admet-470	304	7	-	-	SYM
admet-470	304	8	649	649	NUM
admet-470	304	9	.	.	PUNCT
admet-470	305	1	[	[	X
admet-470	305	2	32	32	NUM
admet-470	305	3	]	]	X
admet-470	305	4	d.g	d.g	PROPN
admet-470	305	5	.	.	PROPN
admet-470	305	6	temesi	temesi	NOUN
admet-470	305	7	,	,	PUNCT
admet-470	305	8	s.	s.	PROPN
admet-470	305	9	martin	martin	PROPN
admet-470	305	10	,	,	PUNCT
admet-470	305	11	r.	r.	PROPN
admet-470	305	12	smith	smith	PROPN
admet-470	305	13	,	,	PUNCT
admet-470	305	14	c.	c.	PROPN
admet-470	305	15	jones	jones	PROPN
admet-470	305	16	,	,	PUNCT
admet-470	305	17	b.	b.	PROPN
admet-470	305	18	middleton	middleton	PROPN
admet-470	305	19	.	.	PUNCT
admet-470	306	1	high	high	ADJ
admet-470	306	2	-	-	PUNCT
admet-470	306	3	throupghput	throupghput	NOUN
admet-470	306	4	metabolic	metabolic	NOUN
admet-470	306	5	stability	stability	NOUN
admet-470	306	6	studies	study	NOUN
admet-470	306	7	in	in	ADP
admet-470	306	8	drug	drug	NOUN
admet-470	306	9	discovery	discovery	NOUN
admet-470	306	10	by	by	ADP
admet-470	306	11	orthogonal	orthogonal	ADJ
admet-470	306	12	acceleration	acceleration	NOUN
admet-470	306	13	time	time	NOUN
admet-470	306	14	-	-	PUNCT
admet-470	306	15	of	of	ADP
admet-470	306	16	-	-	PUNCT
admet-470	306	17	flight	flight	NOUN
admet-470	306	18	(	(	PUNCT
admet-470	306	19	oatof	oatof	PROPN
admet-470	306	20	)	)	PUNCT
admet-470	306	21	with	with	ADP
admet-470	306	22	analogue	analogue	NOUN
admet-470	306	23	-	-	PUNCT
admet-470	306	24	to	to	ADP
admet-470	306	25	-	-	PUNCT
admet-470	306	26	digital	digital	ADJ
admet-470	306	27	signal	signal	NOUN
admet-470	306	28	capture	capture	NOUN
admet-470	306	29	(	(	PUNCT
admet-470	306	30	adc	adc	PROPN
admet-470	306	31	)	)	PUNCT
admet-470	306	32	.	.	PUNCT
admet-470	307	1	rapid	rapid	ADJ
admet-470	307	2	communications	communication	NOUN
admet-470	307	3	in	in	ADP
admet-470	307	4	mass	mass	ADJ
admet-470	307	5	spectometry	spectometry	NOUN
admet-470	307	6	24	24	NUM
admet-470	307	7	(	(	PUNCT
admet-470	307	8	2010	2010	NUM
admet-470	307	9	)	)	PUNCT
admet-470	307	10	1730	1730	NUM
admet-470	307	11	-	-	SYM
admet-470	307	12	1736	1736	NUM
admet-470	307	13	.	.	PUNCT
admet-470	308	1	[	[	X
admet-470	308	2	33	33	NUM
admet-470	308	3	]	]	X
admet-470	308	4	r.p	r.p	PROPN
admet-470	308	5	.	.	PROPN
admet-470	308	6	austin	austin	PROPN
admet-470	308	7	,	,	PUNCT
admet-470	308	8	p.	p.	PROPN
admet-470	308	9	barton	barton	PROPN
admet-470	308	10	,	,	PUNCT
admet-470	308	11	s.	s.	PROPN
admet-470	308	12	mohmed	mohmed	PROPN
admet-470	308	13	,	,	PUNCT
admet-470	308	14	r.j	r.j	PROPN
admet-470	308	15	.	.	PROPN
admet-470	308	16	riley	riley	PROPN
admet-470	308	17	.	.	PUNCT
admet-470	309	1	the	the	DET
admet-470	309	2	binding	binding	NOUN
admet-470	309	3	of	of	ADP
admet-470	309	4	drugs	drug	NOUN
admet-470	309	5	to	to	ADP
admet-470	309	6	hepatocytes	hepatocyte	NOUN
admet-470	309	7	and	and	CCONJ
admet-470	309	8	its	its	PRON
admet-470	309	9	relationship	relationship	NOUN
admet-470	309	10	to	to	ADP
admet-470	309	11	physicochemical	physicochemical	ADJ
admet-470	309	12	properties	property	NOUN
admet-470	309	13	.	.	PUNCT
admet-470	310	1	drug	drug	NOUN
admet-470	310	2	metabolism	metabolism	NOUN
admet-470	310	3	and	and	CCONJ
admet-470	310	4	disposition	disposition	NOUN
admet-470	310	5	33	33	NUM
admet-470	310	6	(	(	PUNCT
admet-470	310	7	2005	2005	NUM
admet-470	310	8	)	)	PUNCT
admet-470	310	9	419	419	NUM
admet-470	310	10	-	-	SYM
admet-470	310	11	425	425	NUM
admet-470	310	12	.	.	PUNCT
admet-470	311	1	[	[	X
admet-470	311	2	34	34	NUM
admet-470	311	3	]	]	X
admet-470	311	4	f.	f.	PROPN
admet-470	311	5	cannavó	cannavó	PROPN
admet-470	311	6	.	.	PUNCT
admet-470	312	1	sensitivity	sensitivity	NOUN
admet-470	312	2	analysis	analysis	NOUN
admet-470	312	3	for	for	ADP
admet-470	312	4	volcanic	volcanic	ADJ
admet-470	312	5	source	source	NOUN
admet-470	312	6	modeling	model	VERB
admet-470	312	7	quality	quality	NOUN
admet-470	312	8	assessment	assessment	NOUN
admet-470	312	9	and	and	CCONJ
admet-470	312	10	model	model	NOUN
admet-470	312	11	selection	selection	NOUN
admet-470	312	12	.	.	PUNCT
admet-470	313	1	computers	computer	NOUN
admet-470	313	2	&	&	CCONJ
admet-470	313	3	geosciences	geoscience	NOUN
admet-470	313	4	44	44	NUM
admet-470	313	5	(	(	PUNCT
admet-470	313	6	2012	2012	NUM
admet-470	313	7	)	)	PUNCT
admet-470	313	8	52	52	NUM
admet-470	313	9	-	-	SYM
admet-470	313	10	59	59	NUM
admet-470	313	11	.	.	PUNCT
admet-470	314	1	[	[	X
admet-470	314	2	35	35	NUM
admet-470	314	3	]	]	SYM
admet-470	314	4	matlab	matlab	PROPN
admet-470	314	5	.	.	PUNCT
admet-470	315	1	the	the	DET
admet-470	315	2	mathworks	mathworks	PROPN
admet-470	315	3	inc	inc	PROPN
admet-470	315	4	.	.	PROPN
admet-470	315	5	,	,	PUNCT
admet-470	315	6	natick	natick	PROPN
admet-470	315	7	,	,	PUNCT
admet-470	315	8	massachusetts	massachusetts	PROPN
admet-470	315	9	,	,	PUNCT
admet-470	315	10	us	we	PRON
admet-470	315	11	,	,	PUNCT
admet-470	315	12	2014	2014	NUM
admet-470	315	13	.	.	PUNCT
admet-470	316	1	[	[	X
admet-470	316	2	36	36	NUM
admet-470	316	3	]	]	X
admet-470	316	4	m.	m.	NOUN
admet-470	316	5	fink	fink	PROPN
admet-470	316	6	,	,	PUNCT
admet-470	316	7	j.j	j.j	PROPN
admet-470	316	8	.	.	PROPN
admet-470	316	9	batzel	batzel	PROPN
admet-470	316	10	,	,	PUNCT
admet-470	316	11	h.	h.	PROPN
admet-470	316	12	tran	tran	PROPN
admet-470	316	13	.	.	PUNCT
admet-470	317	1	a	a	DET
admet-470	317	2	respiratory	respiratory	ADJ
admet-470	317	3	system	system	NOUN
admet-470	317	4	model	model	NOUN
admet-470	317	5	:	:	PUNCT
admet-470	317	6	parameter	parameter	NOUN
admet-470	317	7	estimation	estimation	NOUN
admet-470	317	8	and	and	CCONJ
admet-470	317	9	sensitivity	sensitivity	NOUN
admet-470	317	10	analysis	analysis	NOUN
admet-470	317	11	.	.	PUNCT
admet-470	318	1	cardiovascular	cardiovascular	ADJ
admet-470	318	2	engineering	engineering	NOUN
admet-470	318	3	8	8	NUM
admet-470	318	4	(	(	PUNCT
admet-470	318	5	2008	2008	NUM
admet-470	318	6	)	)	PUNCT
admet-470	318	7	120	120	NUM
admet-470	318	8	-	-	SYM
admet-470	318	9	134	134	NUM
admet-470	318	10	.	.	PUNCT
admet-470	319	1	[	[	X
admet-470	319	2	37	37	NUM
admet-470	319	3	]	]	SYM
admet-470	319	4	http://uk.mathworks.com/matlabcentral/fileexchange/15235-automatic-differentiation-for-matlab	http://uk.mathworks.com/matlabcentral/fileexchange/15235-automatic-differentiation-for-matlab	PROPN
admet-470	319	5	(	(	PUNCT
admet-470	319	6	2017	2017	NUM
admet-470	319	7	-	-	SYM
admet-470	319	8	10	10	NUM
admet-470	319	9	-	-	NUM
admet-470	319	10	11	11	NUM
admet-470	319	11	)	)	PUNCT
admet-470	319	12	.	.	PUNCT
admet-470	320	1	[	[	X
admet-470	320	2	38	38	NUM
admet-470	320	3	]	]	PUNCT
admet-470	320	4	s.	s.	PROPN
admet-470	320	5	winiwarter	winiwarter	PROPN
admet-470	320	6	,	,	PUNCT
admet-470	320	7	b.	b.	PROPN
admet-470	320	8	middleton	middleton	PROPN
admet-470	320	9	,	,	PUNCT
admet-470	320	10	b.	b.	PROPN
admet-470	320	11	jones	jones	PROPN
admet-470	320	12	,	,	PUNCT
admet-470	320	13	p.	p.	PROPN
admet-470	320	14	courtney	courtney	PROPN
admet-470	320	15	,	,	PUNCT
admet-470	320	16	b.	b.	PROPN
admet-470	320	17	lindmark	lindmark	PROPN
admet-470	320	18	,	,	PUNCT
admet-470	320	19	k.m	k.m	PROPN
admet-470	320	20	.	.	PROPN
admet-470	320	21	page	page	NOUN
admet-470	320	22	,	,	PUNCT
admet-470	320	23	a.	a.	NOUN
admet-470	320	24	clark	clark	PROPN
admet-470	320	25	,	,	PUNCT
admet-470	320	26	c.	c.	PROPN
admet-470	320	27	landqvist	landqvist	PROPN
admet-470	320	28	.	.	PUNCT
admet-470	321	1	time	time	NOUN
admet-470	321	2	dependent	dependent	ADJ
admet-470	321	3	analysis	analysis	NOUN
admet-470	321	4	of	of	ADP
admet-470	321	5	assay	assay	ADJ
admet-470	321	6	comparability	comparability	NOUN
admet-470	321	7	:	:	PUNCT
admet-470	321	8	a	a	DET
admet-470	321	9	novel	novel	ADJ
admet-470	321	10	approach	approach	NOUN
admet-470	321	11	to	to	PART
admet-470	321	12	understand	understand	VERB
admet-470	321	13	intraand	intraand	PROPN
admet-470	321	14	intersite	intersite	ADJ
admet-470	321	15	variability	variability	NOUN
admet-470	321	16	over	over	ADP
admet-470	321	17	time	time	NOUN
admet-470	321	18	.	.	PUNCT
admet-470	322	1	journal	journal	PROPN
admet-470	322	2	of	of	ADP
admet-470	322	3	computer	computer	NOUN
admet-470	322	4	-	-	PUNCT
admet-470	322	5	aided	aid	VERB
admet-470	322	6	molecular	molecular	ADJ
admet-470	322	7	design	design	NOUN
admet-470	322	8	29	29	NUM
admet-470	322	9	(	(	PUNCT
admet-470	322	10	2015	2015	NUM
admet-470	322	11	)	)	PUNCT
admet-470	322	12	795	795	NUM
admet-470	322	13	-	-	SYM
admet-470	322	14	807	807	NUM
admet-470	322	15	.	.	PUNCT
admet-470	323	1	[	[	X
admet-470	323	2	39	39	NUM
admet-470	323	3	]	]	PUNCT
admet-470	323	4	a.m.	a.m.	PROPN
admet-470	324	1	davis	davis	PROPN
admet-470	324	2	,	,	PUNCT
admet-470	324	3	d.j	d.j	PROPN
admet-470	324	4	.	.	PROPN
admet-470	324	5	wood	wood	PROPN
admet-470	324	6	.	.	PUNCT
admet-470	325	1	quantitative	quantitative	ADJ
admet-470	325	2	structure	structure	NOUN
admet-470	325	3	-	-	PUNCT
admet-470	325	4	activity	activity	NOUN
admet-470	325	5	relationship	relationship	NOUN
admet-470	325	6	models	model	NOUN
admet-470	325	7	that	that	PRON
admet-470	325	8	stand	stand	VERB
admet-470	325	9	the	the	DET
admet-470	325	10	test	test	NOUN
admet-470	325	11	of	of	ADP
admet-470	325	12	time	time	NOUN
admet-470	325	13	.	.	PUNCT
admet-470	326	1	molecular	molecular	ADJ
admet-470	326	2	pharmaceutics	pharmaceutic	NOUN
admet-470	326	3	10	10	NUM
admet-470	326	4	(	(	PUNCT
admet-470	326	5	2013	2013	NUM
admet-470	326	6	)	)	PUNCT
admet-470	326	7	1183	1183	NUM
admet-470	326	8	-	-	SYM
admet-470	326	9	1190	1190	NUM
admet-470	326	10	.	.	PUNCT
admet-470	327	1	[	[	X
admet-470	327	2	40	40	NUM
admet-470	327	3	]	]	PUNCT
admet-470	327	4	f.	f.	PROPN
admet-470	327	5	lombardo	lombardo	PROPN
admet-470	327	6	,	,	PUNCT
admet-470	327	7	y.	y.	PROPN
admet-470	327	8	jing	jing	PROPN
admet-470	327	9	.	.	PUNCT
admet-470	328	1	in	in	ADP
admet-470	328	2	silico	silico	NOUN
admet-470	328	3	prediction	prediction	NOUN
admet-470	328	4	of	of	ADP
admet-470	328	5	volume	volume	NOUN
admet-470	328	6	of	of	ADP
admet-470	328	7	distribution	distribution	NOUN
admet-470	328	8	in	in	ADP
admet-470	328	9	humans	human	NOUN
admet-470	328	10	.	.	PUNCT
admet-470	329	1	extensive	extensive	ADJ
admet-470	329	2	data	datum	NOUN
admet-470	329	3	set	set	VERB
admet-470	329	4	and	and	CCONJ
admet-470	329	5	the	the	DET
admet-470	329	6	exploration	exploration	NOUN
admet-470	329	7	of	of	ADP
admet-470	329	8	linear	linear	ADJ
admet-470	329	9	and	and	CCONJ
admet-470	329	10	nonlinear	nonlinear	ADJ
admet-470	329	11	methods	method	NOUN
admet-470	329	12	coupled	couple	VERB
admet-470	329	13	with	with	ADP
admet-470	329	14	molecular	molecular	ADJ
admet-470	329	15	interaction	interaction	NOUN
admet-470	329	16	fields	field	NOUN
admet-470	329	17	descriptors	descriptor	NOUN
admet-470	329	18	.	.	PUNCT
admet-470	330	1	journal	journal	PROPN
admet-470	330	2	of	of	ADP
admet-470	330	3	chemical	chemical	ADJ
admet-470	330	4	information	information	NOUN
admet-470	330	5	and	and	CCONJ
admet-470	330	6	modeling	model	VERB
admet-470	330	7	56	56	NUM
admet-470	330	8	(	(	PUNCT
admet-470	330	9	2016	2016	NUM
admet-470	330	10	)	)	PUNCT
admet-470	330	11	2042	2042	NUM
admet-470	330	12	-	-	SYM
admet-470	330	13	2052	2052	NUM
admet-470	330	14	.	.	PUNCT
admet-470	331	1	[	[	X
admet-470	331	2	41	41	NUM
admet-470	331	3	]	]	PUNCT
admet-470	331	4	m.	m.	NOUN
admet-470	331	5	olah	olah	PROPN
admet-470	331	6	,	,	PUNCT
admet-470	331	7	r.	r.	PROPN
admet-470	331	8	rad	rad	PROPN
admet-470	331	9	,	,	PUNCT
admet-470	331	10	l.	l.	PROPN
admet-470	331	11	ostopovici	ostopovici	PROPN
admet-470	331	12	,	,	PUNCT
admet-470	331	13	a.	a.	PROPN
admet-470	331	14	bora	bora	PROPN
admet-470	331	15	,	,	PUNCT
admet-470	331	16	n.	n.	PROPN
admet-470	331	17	hadaruga	hadaruga	PROPN
admet-470	331	18	,	,	PUNCT
admet-470	331	19	d.	d.	PROPN
admet-470	331	20	hadaruga	hadaruga	PROPN
admet-470	331	21	,	,	PUNCT
admet-470	331	22	r.	r.	PROPN
admet-470	331	23	moldovan	moldovan	PROPN
admet-470	331	24	,	,	PUNCT
admet-470	331	25	a.	a.	NOUN
admet-470	331	26	fulias	fulias	PROPN
admet-470	331	27	,	,	PUNCT
admet-470	331	28	m.	m.	NOUN
admet-470	331	29	mractc	mractc	NOUN
admet-470	331	30	,	,	PUNCT
admet-470	331	31	t.i	t.i	PROPN
admet-470	331	32	.	.	PROPN
admet-470	331	33	oprea	oprea	PROPN
admet-470	331	34	,	,	PUNCT
admet-470	331	35	wombat	wombat	NOUN
admet-470	331	36	and	and	CCONJ
admet-470	331	37	wombat	wombat	NOUN
admet-470	331	38	-	-	PUNCT
admet-470	331	39	pk	pk	NOUN
admet-470	331	40	:	:	PUNCT
admet-470	331	41	bioactivity	bioactivity	NOUN
admet-470	331	42	databases	database	NOUN
admet-470	331	43	for	for	ADP
admet-470	331	44	lead	lead	NOUN
admet-470	331	45	and	and	CCONJ
admet-470	331	46	drug	drug	NOUN
admet-470	331	47	discovery	discovery	NOUN
admet-470	331	48	,	,	PUNCT
admet-470	331	49	chemical	chemical	NOUN
admet-470	331	50	biology	biology	NOUN
admet-470	331	51	,	,	PUNCT
admet-470	331	52	wiley	wiley	PROPN
admet-470	331	53	-	-	PUNCT
admet-470	331	54	vch	vch	PROPN
admet-470	331	55	verlag	verlag	PROPN
admet-470	331	56	gmbh2008	gmbh2008	PROPN
admet-470	331	57	,	,	PUNCT
admet-470	331	58	pp	pp	X
admet-470	331	59	.	.	PUNCT
admet-470	332	1	760	760	NUM
admet-470	332	2	-	-	SYM
admet-470	332	3	786	786	NUM
admet-470	332	4	.	.	PUNCT
admet-470	333	1	[	[	X
admet-470	333	2	42	42	NUM
admet-470	333	3	]	]	SYM
admet-470	333	4	pharmapendium	pharmapendium	NOUN
admet-470	333	5	pk	pk	NOUN
admet-470	333	6	fact	fact	NOUN
admet-470	333	7	sheet	sheet	NOUN
admet-470	333	8	.	.	PUNCT
admet-470	334	1	elsevier	elsevier	NOUN
admet-470	334	2	,	,	PUNCT
admet-470	334	3	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_dsolutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_dsolutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	PROPN
admet-470	334	4	(	(	PUNCT
admet-470	334	5	2017	2017	NUM
admet-470	334	6	-	-	SYM
admet-470	334	7	10	10	NUM
admet-470	334	8	-	-	NUM
admet-470	334	9	24	24	NUM
admet-470	334	10	)	)	PUNCT
admet-470	334	11	.	.	PUNCT
admet-470	335	1	©	©	PROPN
admet-470	335	2	2018	2018	NUM
admet-470	335	3	by	by	ADP
admet-470	335	4	the	the	DET
admet-470	335	5	authors	author	NOUN
admet-470	335	6	;	;	PUNCT
admet-470	336	1	licensee	licensee	PROPN
admet-470	336	2	iapc	iapc	PROPN
admet-470	336	3	,	,	PUNCT
admet-470	336	4	zagreb	zagreb	PROPN
admet-470	336	5	,	,	PUNCT
admet-470	336	6	croatia	croatia	PROPN
admet-470	336	7	.	.	PUNCT
admet-470	337	1	this	this	DET
admet-470	337	2	article	article	NOUN
admet-470	337	3	is	be	AUX
admet-470	337	4	an	an	DET
admet-470	337	5	open	open	ADJ
admet-470	337	6	-	-	PUNCT
admet-470	337	7	access	access	NOUN
admet-470	337	8	article	article	NOUN
admet-470	337	9	distributed	distribute	VERB
admet-470	337	10	under	under	ADP
admet-470	337	11	the	the	DET
admet-470	337	12	terms	term	NOUN
admet-470	337	13	and	and	CCONJ
admet-470	337	14	conditions	condition	NOUN
admet-470	337	15	of	of	ADP
admet-470	337	16	the	the	DET
admet-470	337	17	creative	creative	ADJ
admet-470	337	18	commons	common	NOUN
admet-470	337	19	attribution	attribution	NOUN
admet-470	337	20	license	license	NOUN
admet-470	337	21	(	(	PUNCT
admet-470	337	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-470	337	23	)	)	PUNCT
admet-470	337	24	http://www.genettasoft.com/	http://www.genettasoft.com/	NOUN
admet-470	337	25	http://uk.mathworks.com/matlabcentral/fileexchange/15235-automatic-differentiation-for-matlab	http://uk.mathworks.com/matlabcentral/fileexchange/15235-automatic-differentiation-for-matlab	PROPN
admet-470	337	26	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_d-solutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_d-solutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	PROPN
admet-470	337	27	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_d-solutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	https://www.elsevier.com/__data/assets/pdf_file/0009/80694/r_d-solutions_pharmapendium_fcat-sheet_-pharmacokinetics_digital.pdf	PROPN
admet-470	337	28	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN