id	sid	tid	token	lemma	pos
admet-491	1	1	lipophilicity	lipophilicity	NOUN
admet-491	1	2	determination	determination	NOUN
admet-491	1	3	of	of	ADP
admet-491	1	4	acidic	acidic	ADJ
admet-491	1	5	compounds	compound	NOUN
admet-491	1	6	:	:	PUNCT
admet-491	1	7	meekc	meekc	NOUN
admet-491	1	8	as	as	ADP
admet-491	1	9	a	a	DET
admet-491	1	10	reliable	reliable	ADJ
admet-491	1	11	high	high	ADJ
admet-491	1	12	-	-	PUNCT
admet-491	1	13	throughput	throughput	NOUN
admet-491	1	14	methodology	methodology	NOUN
admet-491	1	15	doi	doi	NOUN
admet-491	1	16	:	:	PUNCT
admet-491	1	17	10.5599	10.5599	NUM
admet-491	1	18	/	/	SYM
admet-491	1	19	admet.491	admet.491	PROPN
admet-491	1	20	1	1	NUM
admet-491	1	21	admet	admet	X
admet-491	1	22	&	&	CCONJ
admet-491	1	23	dmpk	dmpk	PROPN
admet-491	1	24	6(2	6(2	NUM
admet-491	1	25	)	)	PUNCT
admet-491	1	26	(	(	PUNCT
admet-491	1	27	2018	2018	NUM
admet-491	1	28	)	)	PUNCT
admet-491	1	29	153	153	NUM
admet-491	1	30	-	-	SYM
admet-491	1	31	161	161	NUM
admet-491	1	32	;	;	PUNCT
admet-491	1	33	doi	doi	NOUN
admet-491	1	34	:	:	PUNCT
admet-491	1	35	http://dx.doi.org/10.5599/admet.491	http://dx.doi.org/10.5599/admet.491	NOUN
admet-491	1	36	open	open	ADJ
admet-491	1	37	access	access	NOUN
admet-491	1	38	:	:	PUNCT
admet-491	1	39	issn	issn	PROPN
admet-491	1	40	:	:	PUNCT
admet-491	1	41	1848	1848	NUM
admet-491	1	42	-	-	SYM
admet-491	1	43	7718	7718	NUM
admet-491	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-491	1	45	original	original	ADJ
admet-491	1	46	scientific	scientific	ADJ
admet-491	1	47	paper	paper	NOUN
admet-491	1	48	lipophilicity	lipophilicity	NOUN
admet-491	1	49	determination	determination	NOUN
admet-491	1	50	of	of	ADP
admet-491	1	51	acidic	acidic	ADJ
admet-491	1	52	compounds	compound	NOUN
admet-491	1	53	:	:	PUNCT
admet-491	1	54	meekc	meekc	NOUN
admet-491	1	55	as	as	ADP
admet-491	1	56	a	a	DET
admet-491	1	57	reliable	reliable	ADJ
admet-491	1	58	high	high	ADJ
admet-491	1	59	-	-	PUNCT
admet-491	1	60	throughput	throughput	NOUN
admet-491	1	61	methodology	methodology	NOUN
admet-491	1	62	xavier	xavier	PROPN
admet-491	1	63	subirats	subirats	PROPN
admet-491	1	64	,	,	PUNCT
admet-491	1	65	lídia	lídia	ADJ
admet-491	1	66	redón	redón	NOUN
admet-491	1	67	and	and	CCONJ
admet-491	1	68	martí	martí	PROPN
admet-491	1	69	rosés	rosés	PROPN
admet-491	1	70	*	*	PROPN
admet-491	1	71	institute	institute	PROPN
admet-491	1	72	of	of	ADP
admet-491	1	73	biomedicine	biomedicine	NOUN
admet-491	1	74	(	(	PUNCT
admet-491	1	75	ibub	ibub	PROPN
admet-491	1	76	)	)	PUNCT
admet-491	1	77	and	and	CCONJ
admet-491	1	78	department	department	NOUN
admet-491	1	79	of	of	ADP
admet-491	1	80	chemical	chemical	PROPN
admet-491	1	81	engineering	engineering	NOUN
admet-491	1	82	and	and	CCONJ
admet-491	1	83	analytical	analytical	ADJ
admet-491	1	84	chemistry	chemistry	NOUN
admet-491	1	85	,	,	PUNCT
admet-491	1	86	universitat	universitat	PROPN
admet-491	1	87	de	de	PROPN
admet-491	1	88	barcelona	barcelona	PROPN
admet-491	1	89	,	,	PUNCT
admet-491	1	90	martí	martí	NOUN
admet-491	1	91	i	i	PRON
admet-491	1	92	franquès	franquès	VERB
admet-491	1	93	1	1	NUM
admet-491	1	94	-	-	SYM
admet-491	1	95	11	11	NUM
admet-491	1	96	,	,	PUNCT
admet-491	1	97	08028	08028	NUM
admet-491	1	98	barcelona	barcelona	PROPN
admet-491	1	99	,	,	PUNCT
admet-491	1	100	spain	spain	PROPN
admet-491	1	101	*	*	PUNCT
admet-491	1	102	corresponding	correspond	VERB
admet-491	1	103	author	author	NOUN
admet-491	1	104	:	:	PUNCT
admet-491	2	1	e	e	NOUN
admet-491	2	2	-	-	NOUN
admet-491	2	3	mail	mail	NOUN
admet-491	2	4	:	:	PUNCT
admet-491	2	5	marti.roses@ub.edu	marti.roses@ub.edu	NOUN
admet-491	2	6	;	;	PUNCT
admet-491	2	7	tel	tel	PROPN
admet-491	2	8	.	.	PUNCT
admet-491	2	9	:	:	PUNCT
admet-491	3	1	+34	+34	ADJ
admet-491	3	2	-	-	PUNCT
admet-491	3	3	934	934	NUM
admet-491	3	4	-	-	PUNCT
admet-491	3	5	039	039	NUM
admet-491	3	6	-	-	PUNCT
admet-491	3	7	275	275	NUM
admet-491	3	8	;	;	PUNCT
admet-491	3	9	fax	fax	NOUN
admet-491	3	10	:	:	PUNCT
admet-491	3	11	+34	+34	ADJ
admet-491	3	12	-	-	PUNCT
admet-491	3	13	934	934	NUM
admet-491	3	14	-	-	PUNCT
admet-491	3	15	021	021	NUM
admet-491	3	16	-	-	PUNCT
admet-491	3	17	233	233	NUM
admet-491	3	18	received	receive	VERB
admet-491	3	19	:	:	PUNCT
admet-491	3	20	december	december	PROPN
admet-491	3	21	15	15	NUM
admet-491	3	22	,	,	PUNCT
admet-491	3	23	2017	2017	NUM
admet-491	3	24	;	;	PUNCT
admet-491	3	25	revised	revise	VERB
admet-491	3	26	:	:	PUNCT
admet-491	3	27	march	march	PROPN
admet-491	3	28	05	05	NUM
admet-491	3	29	,	,	PUNCT
admet-491	3	30	2018	2018	NUM
admet-491	3	31	;	;	PUNCT
admet-491	3	32	available	available	ADJ
admet-491	3	33	online	online	NOUN
admet-491	3	34	:	:	PUNCT
admet-491	3	35	april	april	PROPN
admet-491	3	36	06	06	NUM
admet-491	3	37	,	,	PUNCT
admet-491	3	38	2018	2018	NUM
admet-491	3	39	abstract	abstract	NOUN
admet-491	3	40	in	in	ADP
admet-491	3	41	the	the	DET
admet-491	3	42	present	present	ADJ
admet-491	3	43	study	study	NOUN
admet-491	3	44	a	a	DET
admet-491	3	45	pressure	pressure	NOUN
admet-491	3	46	-	-	PUNCT
admet-491	3	47	assisted	assist	VERB
admet-491	3	48	meekc	meekc	ADJ
admet-491	3	49	method	method	NOUN
admet-491	3	50	with	with	ADP
admet-491	3	51	reversed	reverse	VERB
admet-491	3	52	-	-	PUNCT
admet-491	3	53	polarity	polarity	NOUN
admet-491	3	54	using	use	VERB
admet-491	3	55	a	a	DET
admet-491	3	56	conventional	conventional	ADJ
admet-491	3	57	ce	ce	NOUN
admet-491	3	58	instrument	instrument	NOUN
admet-491	3	59	with	with	ADP
admet-491	3	60	uv	uv	NOUN
admet-491	3	61	detection	detection	NOUN
admet-491	3	62	and	and	CCONJ
admet-491	3	63	uncoated	uncoated	ADJ
admet-491	3	64	fused	fuse	VERB
admet-491	3	65	silica	silica	NOUN
admet-491	3	66	capillaries	capillary	NOUN
admet-491	3	67	is	be	AUX
admet-491	3	68	validated	validate	VERB
admet-491	3	69	as	as	ADP
admet-491	3	70	a	a	DET
admet-491	3	71	high	high	ADJ
admet-491	3	72	-	-	PUNCT
admet-491	3	73	throughput	throughput	NOUN
admet-491	3	74	methodology	methodology	NOUN
admet-491	3	75	for	for	ADP
admet-491	3	76	the	the	DET
admet-491	3	77	lipophilicity	lipophilicity	NOUN
admet-491	3	78	determination	determination	NOUN
admet-491	3	79	of	of	ADP
admet-491	3	80	the	the	DET
admet-491	3	81	neutral	neutral	ADJ
admet-491	3	82	species	specie	NOUN
admet-491	3	83	of	of	ADP
admet-491	3	84	acidic	acidic	ADJ
admet-491	3	85	compounds	compound	NOUN
admet-491	3	86	(	(	PUNCT
admet-491	3	87	pka	pka	X
admet-491	3	88	>	>	X
admet-491	3	89	3.5	3.5	NUM
admet-491	3	90	)	)	PUNCT
admet-491	3	91	.	.	PUNCT
admet-491	4	1	after	after	SCONJ
admet-491	4	2	the	the	DET
admet-491	4	3	calibration	calibration	NOUN
admet-491	4	4	of	of	ADP
admet-491	4	5	the	the	DET
admet-491	4	6	system	system	NOUN
admet-491	4	7	with	with	ADP
admet-491	4	8	four	four	NUM
admet-491	4	9	standard	standard	ADJ
admet-491	4	10	compounds	compound	NOUN
admet-491	4	11	of	of	ADP
admet-491	4	12	known	know	VERB
admet-491	4	13	log	log	NOUN
admet-491	4	14	po	po	PROPN
admet-491	4	15	/	/	SYM
admet-491	4	16	w	w	PROPN
admet-491	4	17	,	,	PUNCT
admet-491	4	18	mass	mass	ADJ
admet-491	4	19	distribution	distribution	NOUN
admet-491	4	20	ratios	ratio	NOUN
admet-491	4	21	(	(	PUNCT
admet-491	4	22	log	log	PROPN
admet-491	4	23	kmeekc	kmeekc	PROPN
admet-491	4	24	)	)	PUNCT
admet-491	4	25	of	of	ADP
admet-491	4	26	new	new	ADJ
admet-491	4	27	molecules	molecule	NOUN
admet-491	4	28	can	can	AUX
admet-491	4	29	be	be	AUX
admet-491	4	30	directly	directly	ADV
admet-491	4	31	converted	convert	VERB
admet-491	4	32	into	into	ADP
admet-491	4	33	log	log	PROPN
admet-491	4	34	po	po	PROPN
admet-491	4	35	/	/	SYM
admet-491	4	36	w	w	NOUN
admet-491	4	37	values	value	NOUN
admet-491	4	38	by	by	ADP
admet-491	4	39	means	mean	NOUN
admet-491	4	40	of	of	ADP
admet-491	4	41	a	a	DET
admet-491	4	42	simple	simple	ADJ
admet-491	4	43	linear	linear	NOUN
admet-491	4	44	equation	equation	NOUN
admet-491	4	45	(	(	PUNCT
admet-491	4	46	log	log	VERB
admet-491	4	47	po	po	PROPN
admet-491	4	48	/	/	SYM
admet-491	4	49	w	w	PROPN
admet-491	4	50	=	=	PROPN
admet-491	4	51	a·log	a·log	NOUN
admet-491	4	52	kmeekc+b	kmeekc+b	NOUN
admet-491	4	53	)	)	PUNCT
admet-491	4	54	.	.	PUNCT
admet-491	5	1	the	the	DET
admet-491	5	2	method	method	NOUN
admet-491	5	3	was	be	AUX
admet-491	5	4	internally	internally	ADV
admet-491	5	5	and	and	CCONJ
admet-491	5	6	externally	externally	ADV
admet-491	5	7	validated	validate	VERB
admet-491	5	8	for	for	ADP
admet-491	5	9	a	a	DET
admet-491	5	10	log	log	NOUN
admet-491	5	11	po	po	NOUN
admet-491	5	12	/	/	SYM
admet-491	5	13	w	w	NOUN
admet-491	5	14	range	range	NOUN
admet-491	5	15	between	between	ADP
admet-491	5	16	-1.54	-1.54	NOUN
admet-491	5	17	and	and	CCONJ
admet-491	5	18	4.75	4.75	NUM
admet-491	5	19	,	,	PUNCT
admet-491	5	20	with	with	ADP
admet-491	5	21	higher	high	ADJ
admet-491	5	22	accuracies	accuracy	NOUN
admet-491	5	23	than	than	ADP
admet-491	5	24	conventional	conventional	ADJ
admet-491	5	25	liquid	liquid	ADJ
admet-491	5	26	chromatographic	chromatographic	ADJ
admet-491	5	27	methods	method	NOUN
admet-491	5	28	.	.	PUNCT
admet-491	6	1	keywords	keyword	NOUN
admet-491	6	2	capillary	capillary	ADJ
admet-491	6	3	electrophoresis	electrophoresis	NOUN
admet-491	6	4	;	;	PUNCT
admet-491	6	5	hydrophobicity	hydrophobicity	NOUN
admet-491	6	6	;	;	PUNCT
admet-491	6	7	log	log	VERB
admet-491	6	8	po	po	PROPN
admet-491	6	9	/	/	SYM
admet-491	6	10	w	w	PROPN
admet-491	6	11	;	;	PUNCT
admet-491	6	12	microemulsion	microemulsion	VERB
admet-491	6	13	electrokinetic	electrokinetic	ADJ
admet-491	6	14	chromatography	chromatography	NOUN
admet-491	6	15	introduction	introduction	NOUN
admet-491	6	16	meekc	meekc	NOUN
admet-491	6	17	as	as	ADP
admet-491	6	18	high	high	ADJ
admet-491	6	19	-	-	PUNCT
admet-491	6	20	throughput	throughput	NOUN
admet-491	6	21	surrogate	surrogate	ADJ
admet-491	6	22	model	model	NOUN
admet-491	6	23	for	for	ADP
admet-491	6	24	the	the	DET
admet-491	6	25	determination	determination	NOUN
admet-491	6	26	of	of	ADP
admet-491	6	27	lipophilicity	lipophilicity	NOUN
admet-491	6	28	according	accord	VERB
admet-491	6	29	to	to	ADP
admet-491	6	30	iupac	iupac	PROPN
admet-491	6	31	[	[	X
admet-491	6	32	1	1	NUM
admet-491	6	33	]	]	PUNCT
admet-491	6	34	,	,	PUNCT
admet-491	6	35	lipophilicity	lipophilicity	NOUN
admet-491	6	36	represents	represent	VERB
admet-491	6	37	the	the	DET
admet-491	6	38	affinity	affinity	NOUN
admet-491	6	39	of	of	ADP
admet-491	6	40	a	a	DET
admet-491	6	41	molecule	molecule	NOUN
admet-491	6	42	or	or	CCONJ
admet-491	6	43	a	a	DET
admet-491	6	44	moiety	moiety	NOUN
admet-491	6	45	for	for	ADP
admet-491	6	46	a	a	DET
admet-491	6	47	lipophilic	lipophilic	ADJ
admet-491	6	48	environment	environment	NOUN
admet-491	6	49	that	that	PRON
admet-491	6	50	is	be	AUX
admet-491	6	51	commonly	commonly	ADV
admet-491	6	52	measured	measure	VERB
admet-491	6	53	by	by	ADP
admet-491	6	54	its	its	PRON
admet-491	6	55	distribution	distribution	NOUN
admet-491	6	56	behavior	behavior	NOUN
admet-491	6	57	in	in	ADP
admet-491	6	58	a	a	DET
admet-491	6	59	biphasic	biphasic	ADJ
admet-491	6	60	system	system	NOUN
admet-491	6	61	.	.	PUNCT
admet-491	7	1	since	since	SCONJ
admet-491	7	2	lipophilicity	lipophilicity	NOUN
admet-491	7	3	plays	play	VERB
admet-491	7	4	a	a	DET
admet-491	7	5	fundamental	fundamental	ADJ
admet-491	7	6	role	role	NOUN
admet-491	7	7	in	in	ADP
admet-491	7	8	the	the	DET
admet-491	7	9	processes	process	NOUN
admet-491	7	10	of	of	ADP
admet-491	7	11	absorption	absorption	NOUN
admet-491	7	12	,	,	PUNCT
admet-491	7	13	distribution	distribution	NOUN
admet-491	7	14	,	,	PUNCT
admet-491	7	15	metabolism	metabolism	NOUN
admet-491	7	16	,	,	PUNCT
admet-491	7	17	excretion	excretion	NOUN
admet-491	7	18	,	,	PUNCT
admet-491	7	19	and	and	CCONJ
admet-491	7	20	toxicity	toxicity	NOUN
admet-491	7	21	(	(	PUNCT
admet-491	7	22	admet	admet	PROPN
admet-491	7	23	)	)	PUNCT
admet-491	7	24	of	of	ADP
admet-491	7	25	chemical	chemical	NOUN
admet-491	7	26	compounds	compound	NOUN
admet-491	7	27	in	in	ADP
admet-491	7	28	biological	biological	ADJ
admet-491	7	29	systems	system	NOUN
admet-491	7	30	,	,	PUNCT
admet-491	7	31	it	it	PRON
admet-491	7	32	is	be	AUX
admet-491	7	33	a	a	DET
admet-491	7	34	relevant	relevant	ADJ
admet-491	7	35	physicochemical	physicochemical	ADJ
admet-491	7	36	property	property	NOUN
admet-491	7	37	to	to	PART
admet-491	7	38	be	be	AUX
admet-491	7	39	determined	determine	VERB
admet-491	7	40	in	in	ADP
admet-491	7	41	the	the	DET
admet-491	7	42	drug	drug	NOUN
admet-491	7	43	discovery	discovery	NOUN
admet-491	7	44	and	and	CCONJ
admet-491	7	45	design	design	NOUN
admet-491	7	46	process	process	NOUN
admet-491	7	47	[	[	X
admet-491	7	48	2	2	NUM
admet-491	7	49	]	]	PUNCT
admet-491	7	50	.	.	PUNCT
admet-491	8	1	different	different	ADJ
admet-491	8	2	lipophilicity	lipophilicity	NOUN
admet-491	8	3	indexes	index	NOUN
admet-491	8	4	can	can	AUX
admet-491	8	5	be	be	AUX
admet-491	8	6	obtained	obtain	VERB
admet-491	8	7	depending	depend	VERB
admet-491	8	8	on	on	ADP
admet-491	8	9	the	the	DET
admet-491	8	10	particular	particular	ADJ
admet-491	8	11	biphasic	biphasic	ADJ
admet-491	8	12	system	system	NOUN
admet-491	8	13	used	use	VERB
admet-491	8	14	,	,	PUNCT
admet-491	8	15	but	but	CCONJ
admet-491	8	16	the	the	DET
admet-491	8	17	most	most	ADV
admet-491	8	18	widely	widely	ADV
admet-491	8	19	used	use	VERB
admet-491	8	20	is	be	AUX
admet-491	8	21	the	the	DET
admet-491	8	22	n	n	CCONJ
admet-491	8	23	-	-	PUNCT
admet-491	8	24	octanol	octanol	NOUN
admet-491	8	25	/	/	SYM
admet-491	8	26	water	water	NOUN
admet-491	8	27	partition	partition	NOUN
admet-491	8	28	coefficient	coefficient	NOUN
admet-491	8	29	(	(	PUNCT
admet-491	8	30	log	log	VERB
admet-491	8	31	po	po	PROPN
admet-491	8	32	/	/	SYM
admet-491	8	33	w	w	PROPN
admet-491	8	34	,	,	PUNCT
admet-491	8	35	also	also	ADV
admet-491	8	36	indicated	indicate	VERB
admet-491	8	37	as	as	ADP
admet-491	8	38	log	log	NOUN
admet-491	8	39	ko	ko	PROPN
admet-491	8	40	/	/	SYM
admet-491	8	41	w	w	PROPN
admet-491	8	42	)	)	PUNCT
admet-491	8	43	.	.	PUNCT
admet-491	9	1	moreover	moreover	ADV
admet-491	9	2	,	,	PUNCT
admet-491	9	3	since	since	SCONJ
admet-491	9	4	lipophilicity	lipophilicity	NOUN
admet-491	9	5	is	be	AUX
admet-491	9	6	a	a	DET
admet-491	9	7	critical	critical	ADJ
admet-491	9	8	parameter	parameter	NOUN
admet-491	9	9	for	for	ADP
admet-491	9	10	chemical	chemical	NOUN
admet-491	9	11	safety	safety	NOUN
admet-491	9	12	assessment	assessment	NOUN
admet-491	9	13	,	,	PUNCT
admet-491	9	14	according	accord	VERB
admet-491	9	15	to	to	ADP
admet-491	9	16	the	the	DET
admet-491	9	17	reach	reach	NOUN
admet-491	9	18	regulation	regulation	NOUN
admet-491	9	19	(	(	PUNCT
admet-491	9	20	(	(	PUNCT
admet-491	9	21	ec	ec	PROPN
admet-491	9	22	)	)	PUNCT
admet-491	9	23	no	no	DET
admet-491	9	24	1907/2006	1907/2006	NUM
admet-491	9	25	)	)	PUNCT
admet-491	9	26	log	log	VERB
admet-491	9	27	po	po	NOUN
admet-491	9	28	/	/	SYM
admet-491	9	29	w	w	PROPN
admet-491	9	30	must	must	AUX
admet-491	9	31	be	be	AUX
admet-491	9	32	reported	report	VERB
admet-491	9	33	for	for	ADP
admet-491	9	34	any	any	DET
admet-491	9	35	organic	organic	ADJ
admet-491	9	36	compound	compound	NOUN
admet-491	9	37	produced	produce	VERB
admet-491	9	38	in	in	ADP
admet-491	9	39	quantities	quantity	NOUN
admet-491	9	40	of	of	ADP
admet-491	9	41	one	one	NUM
admet-491	9	42	tonne	tonne	NOUN
admet-491	9	43	or	or	CCONJ
admet-491	9	44	more	more	ADJ
admet-491	9	45	per	per	ADP
admet-491	9	46	year	year	NOUN
admet-491	9	47	.	.	PUNCT
admet-491	10	1	thus	thus	ADV
admet-491	10	2	,	,	PUNCT
admet-491	10	3	two	two	NUM
admet-491	10	4	test	test	NOUN
admet-491	10	5	procedures	procedure	NOUN
admet-491	10	6	are	be	AUX
admet-491	10	7	described	describe	VERB
admet-491	10	8	in	in	ADP
admet-491	10	9	the	the	DET
admet-491	10	10	test	test	NOUN
admet-491	10	11	methods	method	NOUN
admet-491	10	12	regulation	regulation	NOUN
admet-491	10	13	(	(	PUNCT
admet-491	10	14	(	(	PUNCT
admet-491	10	15	ec	ec	PROPN
admet-491	10	16	)	)	PUNCT
admet-491	10	17	no	no	DET
admet-491	10	18	440/2008	440/2008	NOUN
admet-491	10	19	):	):	PUNCT
admet-491	10	20	a	a	DET
admet-491	10	21	direct	direct	ADJ
admet-491	10	22	measurement	measurement	NOUN
admet-491	10	23	via	via	ADP
admet-491	10	24	shake	shake	NOUN
admet-491	10	25	-	-	PUNCT
admet-491	10	26	flask	flask	NOUN
admet-491	10	27	methods	method	NOUN
admet-491	10	28	[	[	X
admet-491	10	29	3	3	X
admet-491	10	30	]	]	PUNCT
admet-491	10	31	and	and	CCONJ
admet-491	10	32	a	a	DET
admet-491	10	33	correlation	correlation	NOUN
admet-491	10	34	approach	approach	NOUN
admet-491	10	35	by	by	ADP
admet-491	10	36	means	mean	NOUN
admet-491	10	37	of	of	ADP
admet-491	10	38	hplc	hplc	NOUN
admet-491	10	39	[	[	X
admet-491	10	40	4	4	NUM
admet-491	10	41	]	]	PUNCT
admet-491	10	42	.	.	PUNCT
admet-491	11	1	however	however	ADV
admet-491	11	2	,	,	PUNCT
admet-491	11	3	other	other	ADJ
admet-491	11	4	experimental	experimental	ADJ
admet-491	11	5	methods	method	NOUN
admet-491	11	6	can	can	AUX
admet-491	11	7	be	be	AUX
admet-491	11	8	used	use	VERB
admet-491	11	9	provided	provide	VERB
admet-491	11	10	that	that	SCONJ
admet-491	11	11	they	they	PRON
admet-491	11	12	show	show	VERB
admet-491	11	13	an	an	DET
admet-491	11	14	acceptable	acceptable	ADJ
admet-491	11	15	level	level	NOUN
admet-491	11	16	of	of	ADP
admet-491	11	17	quality	quality	NOUN
admet-491	11	18	assurance	assurance	NOUN
admet-491	12	1	[	[	X
admet-491	12	2	5	5	NUM
admet-491	12	3	]	]	PUNCT
admet-491	12	4	.	.	PUNCT
admet-491	13	1	this	this	PRON
admet-491	13	2	is	be	AUX
admet-491	13	3	clearly	clearly	ADV
admet-491	13	4	the	the	DET
admet-491	13	5	case	case	NOUN
admet-491	13	6	of	of	ADP
admet-491	13	7	dual	dual	ADJ
admet-491	13	8	-	-	PUNCT
admet-491	13	9	phase	phase	NOUN
admet-491	13	10	potentiometric	potentiometric	ADJ
admet-491	13	11	titration	titration	NOUN
admet-491	13	12	procedures	procedure	NOUN
admet-491	13	13	[	[	X
admet-491	13	14	6,7	6,7	NUM
admet-491	13	15	]	]	PUNCT
admet-491	13	16	,	,	PUNCT
admet-491	13	17	commonly	commonly	ADV
admet-491	13	18	used	use	VERB
admet-491	13	19	in	in	ADP
admet-491	13	20	pharmaceutical	pharmaceutical	ADJ
admet-491	13	21	research	research	NOUN
admet-491	13	22	for	for	ADP
admet-491	13	23	ionizable	ionizable	ADJ
admet-491	13	24	drugs	drug	NOUN
admet-491	13	25	with	with	ADP
admet-491	13	26	pka	pka	PROPN
admet-491	13	27	values	value	NOUN
admet-491	13	28	in	in	ADP
admet-491	13	29	a	a	DET
admet-491	13	30	measurable	measurable	ADJ
admet-491	13	31	ph	ph	NOUN
admet-491	13	32	range	range	NOUN
admet-491	13	33	(	(	PUNCT
admet-491	13	34	2	2	NUM
admet-491	13	35	-	-	SYM
admet-491	13	36	12	12	NUM
admet-491	13	37	)	)	PUNCT
admet-491	13	38	,	,	PUNCT
admet-491	13	39	which	which	PRON
admet-491	13	40	provide	provide	VERB
admet-491	13	41	reliable	reliable	ADJ
admet-491	13	42	and	and	CCONJ
admet-491	13	43	accurate	accurate	ADJ
admet-491	13	44	log	log	PROPN
admet-491	13	45	po	po	PROPN
admet-491	13	46	/	/	SYM
admet-491	13	47	w	w	NOUN
admet-491	13	48	values	value	NOUN
admet-491	13	49	[	[	X
admet-491	13	50	8	8	NUM
admet-491	13	51	]	]	PUNCT
admet-491	13	52	.	.	PUNCT
admet-491	14	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-491	14	2	mailto:marti.roses@ub.edu	mailto:marti.roses@ub.edu	PROPN
admet-491	14	3	marti	marti	PROPN
admet-491	14	4	rosés	rosés	PROPN
admet-491	14	5	et	et	PROPN
admet-491	14	6	al	al	PROPN
admet-491	14	7	.	.	PROPN
admet-491	14	8	admet	admet	PROPN
admet-491	14	9	&	&	CCONJ
admet-491	14	10	dmpk	dmpk	PROPN
admet-491	14	11	6(2	6(2	NUM
admet-491	14	12	)	)	PUNCT
admet-491	14	13	(	(	PUNCT
admet-491	14	14	2018	2018	NUM
admet-491	14	15	)	)	PUNCT
admet-491	14	16	153	153	NUM
admet-491	14	17	-	-	SYM
admet-491	14	18	161	161	NUM
admet-491	14	19	154	154	NUM
admet-491	14	20	several	several	ADJ
admet-491	14	21	methods	method	NOUN
admet-491	14	22	based	base	VERB
admet-491	14	23	on	on	ADP
admet-491	14	24	chromatographic	chromatographic	ADJ
admet-491	14	25	retention	retention	NOUN
admet-491	14	26	have	have	AUX
admet-491	14	27	been	be	AUX
admet-491	14	28	proposed	propose	VERB
admet-491	14	29	in	in	ADP
admet-491	14	30	order	order	NOUN
admet-491	14	31	to	to	PART
admet-491	14	32	measure	measure	VERB
admet-491	14	33	lipophilicity	lipophilicity	NOUN
admet-491	14	34	,	,	PUNCT
admet-491	14	35	mainly	mainly	ADV
admet-491	14	36	using	use	VERB
admet-491	14	37	reversed	reverse	VERB
admet-491	14	38	-	-	PUNCT
admet-491	14	39	phase	phase	NOUN
admet-491	14	40	columns	column	NOUN
admet-491	14	41	and	and	CCONJ
admet-491	14	42	acetonitrile	acetonitrile	ADJ
admet-491	14	43	/	/	SYM
admet-491	14	44	aqueous	aqueous	ADJ
admet-491	14	45	buffer	buffer	NOUN
admet-491	14	46	mobile	mobile	ADJ
admet-491	14	47	phases	phase	NOUN
admet-491	14	48	[	[	X
admet-491	14	49	9	9	NUM
admet-491	14	50	]	]	PUNCT
admet-491	14	51	.	.	PUNCT
admet-491	15	1	these	these	DET
admet-491	15	2	approaches	approach	NOUN
admet-491	15	3	are	be	AUX
admet-491	15	4	much	much	ADV
admet-491	15	5	more	more	ADJ
admet-491	15	6	time	time	NOUN
admet-491	15	7	-	-	PUNCT
admet-491	15	8	efficient	efficient	ADJ
admet-491	15	9	compared	compare	VERB
admet-491	15	10	to	to	ADP
admet-491	15	11	shake	shake	VERB
admet-491	15	12	-	-	PUNCT
admet-491	15	13	flask	flask	NOUN
admet-491	15	14	and	and	CCONJ
admet-491	15	15	potentiometric	potentiometric	ADJ
admet-491	15	16	methods	method	NOUN
admet-491	15	17	,	,	PUNCT
admet-491	15	18	with	with	ADP
admet-491	15	19	the	the	DET
admet-491	15	20	additional	additional	ADJ
admet-491	15	21	benefit	benefit	NOUN
admet-491	15	22	of	of	ADP
admet-491	15	23	a	a	DET
admet-491	15	24	separation	separation	NOUN
admet-491	15	25	technique	technique	NOUN
admet-491	15	26	that	that	PRON
admet-491	15	27	does	do	AUX
admet-491	15	28	not	not	PART
admet-491	15	29	require	require	VERB
admet-491	15	30	high	high	ADJ
admet-491	15	31	purity	purity	NOUN
admet-491	15	32	samples	sample	NOUN
admet-491	15	33	.	.	PUNCT
admet-491	16	1	however	however	ADV
admet-491	16	2	,	,	PUNCT
admet-491	16	3	the	the	DET
admet-491	16	4	accuracy	accuracy	NOUN
admet-491	16	5	of	of	ADP
admet-491	16	6	the	the	DET
admet-491	16	7	estimated	estimate	VERB
admet-491	16	8	log	log	NOUN
admet-491	16	9	po	po	NOUN
admet-491	16	10	/	/	SYM
admet-491	16	11	w	w	NOUN
admet-491	16	12	values	value	NOUN
admet-491	16	13	depends	depend	VERB
admet-491	16	14	to	to	ADP
admet-491	16	15	a	a	DET
admet-491	16	16	great	great	ADJ
admet-491	16	17	extent	extent	NOUN
admet-491	16	18	on	on	ADP
admet-491	16	19	the	the	DET
admet-491	16	20	similarity	similarity	NOUN
admet-491	16	21	between	between	ADP
admet-491	16	22	the	the	DET
admet-491	16	23	calibration	calibration	NOUN
admet-491	16	24	standards	standard	NOUN
admet-491	16	25	and	and	CCONJ
admet-491	16	26	the	the	DET
admet-491	16	27	sample	sample	NOUN
admet-491	16	28	compounds	compound	VERB
admet-491	16	29	.	.	PUNCT
admet-491	17	1	for	for	ADP
admet-491	17	2	instance	instance	NOUN
admet-491	17	3	,	,	PUNCT
admet-491	17	4	octanol	octanol	NOUN
admet-491	17	5	and	and	CCONJ
admet-491	17	6	c18	c18	NOUN
admet-491	17	7	phases	phase	NOUN
admet-491	17	8	exhibit	exhibit	VERB
admet-491	17	9	a	a	DET
admet-491	17	10	different	different	ADJ
admet-491	17	11	interaction	interaction	NOUN
admet-491	17	12	with	with	ADP
admet-491	17	13	hydrogen	hydrogen	NOUN
admet-491	17	14	-	-	PUNCT
admet-491	17	15	bond	bond	NOUN
admet-491	17	16	donor	donor	NOUN
admet-491	17	17	solutes	solute	NOUN
admet-491	17	18	;	;	PUNCT
admet-491	17	19	in	in	ADP
admet-491	17	20	the	the	DET
admet-491	17	21	chromatographic	chromatographic	ADJ
admet-491	17	22	system	system	NOUN
admet-491	17	23	solutes	solute	VERB
admet-491	17	24	with	with	ADP
admet-491	17	25	h	h	NOUN
admet-491	17	26	-	-	PUNCT
admet-491	17	27	bond	bond	NOUN
admet-491	17	28	acidity	acidity	NOUN
admet-491	17	29	are	be	AUX
admet-491	17	30	discouraged	discourage	VERB
admet-491	17	31	from	from	ADP
admet-491	17	32	partitioning	partition	VERB
admet-491	17	33	out	out	ADP
admet-491	17	34	of	of	ADP
admet-491	17	35	the	the	DET
admet-491	17	36	hydro	hydro	NOUN
admet-491	17	37	-	-	PUNCT
admet-491	17	38	organic	organic	ADJ
admet-491	17	39	mixture	mixture	NOUN
admet-491	17	40	and	and	CCONJ
admet-491	17	41	into	into	ADP
admet-491	17	42	the	the	DET
admet-491	17	43	poorer	poor	ADJ
admet-491	17	44	h	h	ADJ
admet-491	17	45	-	-	PUNCT
admet-491	17	46	bond	bond	NOUN
admet-491	17	47	acceptor	acceptor	NOUN
admet-491	17	48	c18	c18	NOUN
admet-491	17	49	phase	phase	NOUN
admet-491	17	50	,	,	PUNCT
admet-491	17	51	whereas	whereas	SCONJ
admet-491	17	52	octanol	octanol	NOUN
admet-491	17	53	(	(	PUNCT
admet-491	17	54	either	either	CCONJ
admet-491	17	55	containing	contain	VERB
admet-491	17	56	water	water	NOUN
admet-491	17	57	or	or	CCONJ
admet-491	17	58	other	other	ADJ
admet-491	17	59	h	h	ADJ
admet-491	17	60	-	-	PUNCT
admet-491	17	61	bond	bond	NOUN
admet-491	17	62	acceptor	acceptor	NOUN
admet-491	17	63	moieties	moiety	NOUN
admet-491	17	64	)	)	PUNCT
admet-491	17	65	can	can	AUX
admet-491	17	66	form	form	VERB
admet-491	17	67	hydrogen	hydrogen	NOUN
admet-491	17	68	bonds	bond	NOUN
admet-491	17	69	.	.	PUNCT
admet-491	18	1	therefore	therefore	ADV
admet-491	18	2	,	,	PUNCT
admet-491	18	3	the	the	DET
admet-491	18	4	introduction	introduction	NOUN
admet-491	18	5	of	of	ADP
admet-491	18	6	molecular	molecular	ADJ
admet-491	18	7	descriptors	descriptor	NOUN
admet-491	18	8	,	,	PUNCT
admet-491	18	9	either	either	CCONJ
admet-491	18	10	experimental	experimental	ADJ
admet-491	18	11	or	or	CCONJ
admet-491	18	12	calculated	calculate	VERB
admet-491	18	13	,	,	PUNCT
admet-491	18	14	allows	allow	VERB
admet-491	18	15	better	well	ADJ
admet-491	18	16	correlations	correlation	NOUN
admet-491	18	17	between	between	ADP
admet-491	18	18	chromatographic	chromatographic	ADJ
admet-491	18	19	retention	retention	NOUN
admet-491	18	20	and	and	CCONJ
admet-491	18	21	log	log	VERB
admet-491	18	22	po	po	PROPN
admet-491	18	23	/	/	SYM
admet-491	18	24	w	w	NOUN
admet-491	18	25	values	value	NOUN
admet-491	18	26	[	[	X
admet-491	18	27	9–12	9–12	X
admet-491	18	28	]	]	PUNCT
admet-491	18	29	,	,	PUNCT
admet-491	18	30	but	but	CCONJ
admet-491	18	31	is	be	AUX
admet-491	18	32	limited	limit	VERB
admet-491	18	33	to	to	ADP
admet-491	18	34	unionized	unionized	ADJ
admet-491	18	35	molecules	molecule	NOUN
admet-491	18	36	.	.	PUNCT
admet-491	19	1	however	however	ADV
admet-491	19	2	,	,	PUNCT
admet-491	19	3	a	a	DET
admet-491	19	4	lower	low	ADJ
admet-491	19	5	accuracy	accuracy	NOUN
admet-491	19	6	from	from	ADP
admet-491	19	7	chromatographic	chromatographic	ADJ
admet-491	19	8	methods	method	NOUN
admet-491	19	9	(	(	PUNCT
admet-491	19	10	±0.5	±0.5	PROPN
admet-491	19	11	log	log	NOUN
admet-491	19	12	units	unit	NOUN
admet-491	19	13	[	[	X
admet-491	19	14	4	4	NUM
admet-491	19	15	]	]	PUNCT
admet-491	19	16	)	)	PUNCT
admet-491	19	17	can	can	AUX
admet-491	19	18	be	be	AUX
admet-491	19	19	expected	expect	VERB
admet-491	19	20	in	in	ADP
admet-491	19	21	relation	relation	NOUN
admet-491	19	22	to	to	ADP
admet-491	19	23	the	the	DET
admet-491	19	24	shake	shake	NOUN
admet-491	19	25	-	-	PUNCT
admet-491	19	26	flask	flask	NOUN
admet-491	19	27	method	method	NOUN
admet-491	19	28	(	(	PUNCT
admet-491	19	29	±0.3	±0.3	PROPN
admet-491	19	30	[	[	X
admet-491	19	31	3	3	NUM
admet-491	19	32	]	]	PUNCT
admet-491	19	33	)	)	PUNCT
admet-491	19	34	.	.	PUNCT
admet-491	20	1	in	in	ADP
admet-491	20	2	previous	previous	ADJ
admet-491	20	3	papers	paper	NOUN
admet-491	20	4	[	[	X
admet-491	20	5	13,14	13,14	X
admet-491	20	6	]	]	X
admet-491	20	7	an	an	DET
admet-491	20	8	approach	approach	NOUN
admet-491	20	9	based	base	VERB
admet-491	20	10	on	on	ADP
admet-491	20	11	microemulsion	microemulsion	PROPN
admet-491	20	12	electrokinetic	electrokinetic	ADJ
admet-491	20	13	chromatography	chromatography	NOUN
admet-491	20	14	(	(	PUNCT
admet-491	20	15	meekc	meekc	PROPN
admet-491	20	16	)	)	PUNCT
admet-491	20	17	was	be	AUX
admet-491	20	18	successfully	successfully	ADV
admet-491	20	19	demonstrated	demonstrate	VERB
admet-491	20	20	as	as	ADP
admet-491	20	21	an	an	DET
admet-491	20	22	indirect	indirect	ADJ
admet-491	20	23	method	method	NOUN
admet-491	20	24	for	for	ADP
admet-491	20	25	log	log	PROPN
admet-491	20	26	po	po	PROPN
admet-491	20	27	/	/	SYM
admet-491	20	28	w	w	NOUN
admet-491	20	29	determination	determination	NOUN
admet-491	20	30	for	for	ADP
admet-491	20	31	compounds	compound	NOUN
admet-491	20	32	of	of	ADP
admet-491	20	33	pharmaceutical	pharmaceutical	ADJ
admet-491	20	34	interest	interest	NOUN
admet-491	20	35	,	,	PUNCT
admet-491	20	36	using	use	VERB
admet-491	20	37	uv	uv	NOUN
admet-491	20	38	detection	detection	NOUN
admet-491	20	39	or	or	CCONJ
admet-491	20	40	hyphenated	hyphenate	VERB
admet-491	20	41	to	to	ADP
admet-491	20	42	an	an	DET
admet-491	20	43	ms	ms	NOUN
admet-491	20	44	with	with	ADP
admet-491	20	45	an	an	DET
admet-491	20	46	atmospheric	atmospheric	ADJ
admet-491	20	47	pressure	pressure	NOUN
admet-491	20	48	photoionizaion	photoionizaion	NOUN
admet-491	20	49	(	(	PUNCT
admet-491	20	50	appi	appi	NOUN
admet-491	20	51	)	)	PUNCT
admet-491	20	52	source	source	NOUN
admet-491	20	53	[	[	X
admet-491	20	54	15	15	NUM
admet-491	20	55	]	]	PUNCT
admet-491	20	56	.	.	PUNCT
admet-491	21	1	meekc	meekc	PROPN
admet-491	21	2	is	be	AUX
admet-491	21	3	a	a	DET
admet-491	21	4	chromatographic	chromatographic	ADJ
admet-491	21	5	technique	technique	NOUN
admet-491	21	6	(	(	PUNCT
admet-491	21	7	microemulsion	microemulsion	NOUN
admet-491	21	8	(	(	PUNCT
admet-491	21	9	me	i	PRON
admet-491	21	10	)	)	PUNCT
admet-491	21	11	droplets	droplet	VERB
admet-491	21	12	acting	act	VERB
admet-491	21	13	as	as	ADP
admet-491	21	14	pseudo	pseudo	NOUN
admet-491	21	15	-	-	ADJ
admet-491	21	16	stationary	stationary	ADJ
admet-491	21	17	phase	phase	NOUN
admet-491	21	18	)	)	PUNCT
admet-491	21	19	,	,	PUNCT
admet-491	21	20	and	and	CCONJ
admet-491	21	21	requires	require	VERB
admet-491	21	22	significantly	significantly	ADV
admet-491	21	23	shorter	short	ADJ
admet-491	21	24	analysis	analysis	NOUN
admet-491	21	25	times	time	NOUN
admet-491	21	26	than	than	ADP
admet-491	21	27	reference	reference	NOUN
admet-491	21	28	shakeflask	shakeflask	NOUN
admet-491	21	29	and	and	CCONJ
admet-491	21	30	potentiometric	potentiometric	ADJ
admet-491	21	31	methods	method	NOUN
admet-491	21	32	,	,	PUNCT
admet-491	21	33	avoiding	avoid	VERB
admet-491	21	34	in	in	ADP
admet-491	21	35	addition	addition	NOUN
admet-491	21	36	the	the	DET
admet-491	21	37	requirement	requirement	NOUN
admet-491	21	38	of	of	ADP
admet-491	21	39	high	high	ADJ
admet-491	21	40	-	-	PUNCT
admet-491	21	41	purity	purity	NOUN
admet-491	21	42	samples	sample	NOUN
admet-491	21	43	.	.	PUNCT
admet-491	22	1	although	although	SCONJ
admet-491	22	2	it	it	PRON
admet-491	22	3	can	can	AUX
admet-491	22	4	only	only	ADV
admet-491	22	5	be	be	AUX
admet-491	22	6	applied	apply	VERB
admet-491	22	7	to	to	ADP
admet-491	22	8	neutral	neutral	ADJ
admet-491	22	9	species	specie	NOUN
admet-491	22	10	,	,	PUNCT
admet-491	22	11	the	the	DET
admet-491	22	12	broad	broad	ADJ
admet-491	22	13	ph	ph	ADJ
admet-491	22	14	range	range	NOUN
admet-491	22	15	of	of	ADP
admet-491	22	16	application	application	NOUN
admet-491	22	17	(	(	PUNCT
admet-491	22	18	from	from	ADP
admet-491	22	19	ph	ph	NOUN
admet-491	22	20	2	2	NUM
admet-491	22	21	to	to	ADP
admet-491	22	22	12	12	NUM
admet-491	22	23	)	)	PUNCT
admet-491	22	24	allows	allow	VERB
admet-491	22	25	,	,	PUNCT
admet-491	22	26	in	in	ADP
admet-491	22	27	most	most	ADJ
admet-491	22	28	cases	case	NOUN
admet-491	22	29	,	,	PUNCT
admet-491	22	30	the	the	DET
admet-491	22	31	finding	finding	NOUN
admet-491	22	32	of	of	ADP
admet-491	22	33	experimental	experimental	ADJ
admet-491	22	34	conditions	condition	NOUN
admet-491	22	35	which	which	PRON
admet-491	22	36	ensure	ensure	VERB
admet-491	22	37	the	the	DET
admet-491	22	38	analyte	analyte	NOUN
admet-491	22	39	is	be	AUX
admet-491	22	40	in	in	ADP
admet-491	22	41	its	its	PRON
admet-491	22	42	neutral	neutral	ADJ
admet-491	22	43	form	form	NOUN
admet-491	22	44	.	.	PUNCT
admet-491	23	1	this	this	PRON
admet-491	23	2	is	be	AUX
admet-491	23	3	clearly	clearly	ADV
admet-491	23	4	an	an	DET
admet-491	23	5	advantage	advantage	NOUN
admet-491	23	6	over	over	ADP
admet-491	23	7	conventional	conventional	ADJ
admet-491	23	8	chromatographic	chromatographic	ADJ
admet-491	23	9	methods	method	NOUN
admet-491	23	10	,	,	PUNCT
admet-491	23	11	since	since	SCONJ
admet-491	23	12	column	column	NOUN
admet-491	23	13	stability	stability	NOUN
admet-491	23	14	might	might	AUX
admet-491	23	15	be	be	AUX
admet-491	23	16	a	a	DET
admet-491	23	17	critical	critical	ADJ
admet-491	23	18	factor	factor	NOUN
admet-491	23	19	at	at	ADP
admet-491	23	20	such	such	ADJ
admet-491	23	21	extreme	extreme	ADJ
admet-491	23	22	ph	ph	ADJ
admet-491	23	23	values	value	NOUN
admet-491	23	24	.	.	PUNCT
admet-491	24	1	in	in	ADP
admet-491	24	2	addition	addition	NOUN
admet-491	24	3	,	,	PUNCT
admet-491	24	4	and	and	CCONJ
admet-491	24	5	this	this	PRON
admet-491	24	6	is	be	AUX
admet-491	24	7	maybe	maybe	ADV
admet-491	24	8	the	the	DET
admet-491	24	9	most	most	ADV
admet-491	24	10	significant	significant	ADJ
admet-491	24	11	advantage	advantage	NOUN
admet-491	24	12	over	over	ADP
admet-491	24	13	traditional	traditional	ADJ
admet-491	24	14	chromatographic	chromatographic	ADJ
admet-491	24	15	methods	method	NOUN
admet-491	24	16	,	,	PUNCT
admet-491	24	17	meekc	meekc	ADJ
admet-491	24	18	measurements	measurement	NOUN
admet-491	24	19	can	can	AUX
admet-491	24	20	be	be	AUX
admet-491	24	21	accurately	accurately	ADV
admet-491	24	22	correlated	correlate	VERB
admet-491	24	23	with	with	ADP
admet-491	24	24	log	log	PROPN
admet-491	24	25	po	po	PROPN
admet-491	24	26	/	/	SYM
admet-491	24	27	w	w	NOUN
admet-491	24	28	without	without	ADP
admet-491	24	29	the	the	DET
admet-491	24	30	need	need	NOUN
admet-491	24	31	of	of	ADP
admet-491	24	32	molecular	molecular	ADJ
admet-491	24	33	descriptors	descriptor	NOUN
admet-491	24	34	since	since	SCONJ
admet-491	24	35	me	i	PRON
admet-491	24	36	are	be	AUX
admet-491	24	37	better	well	ADJ
admet-491	24	38	surrogates	surrogate	NOUN
admet-491	24	39	of	of	ADP
admet-491	24	40	n	n	NOUN
admet-491	24	41	-	-	PUNCT
admet-491	24	42	octanol	octanol	NOUN
admet-491	24	43	/	/	SYM
admet-491	24	44	water	water	NOUN
admet-491	24	45	systems	system	NOUN
admet-491	24	46	than	than	SCONJ
admet-491	24	47	c18	c18	NOUN
admet-491	24	48	stationary	stationary	ADJ
admet-491	24	49	phases	phase	NOUN
admet-491	24	50	.	.	PUNCT
admet-491	25	1	additionally	additionally	ADV
admet-491	25	2	,	,	PUNCT
admet-491	25	3	running	run	VERB
admet-491	25	4	costs	cost	NOUN
admet-491	25	5	of	of	ADP
admet-491	25	6	capillary	capillary	ADJ
admet-491	25	7	electrophoresis	electrophoresis	NOUN
admet-491	25	8	techniques	technique	NOUN
admet-491	25	9	are	be	AUX
admet-491	25	10	lower	low	ADJ
admet-491	25	11	because	because	SCONJ
admet-491	25	12	of	of	ADP
admet-491	25	13	the	the	DET
admet-491	25	14	lower	low	ADJ
admet-491	25	15	price	price	NOUN
admet-491	25	16	of	of	ADP
admet-491	25	17	fused	fuse	VERB
admet-491	25	18	silica	silica	NOUN
admet-491	25	19	capillaries	capillary	NOUN
admet-491	25	20	in	in	ADP
admet-491	25	21	relation	relation	NOUN
admet-491	25	22	to	to	ADP
admet-491	25	23	chromatographic	chromatographic	ADJ
admet-491	25	24	columns	column	NOUN
admet-491	25	25	and	and	CCONJ
admet-491	25	26	the	the	DET
admet-491	25	27	lower	low	ADJ
admet-491	25	28	solvent	solvent	ADJ
admet-491	25	29	consumption	consumption	NOUN
admet-491	25	30	.	.	PUNCT
admet-491	26	1	last	last	ADJ
admet-491	26	2	but	but	CCONJ
admet-491	26	3	not	not	PART
admet-491	26	4	least	least	ADJ
admet-491	26	5	,	,	PUNCT
admet-491	26	6	meekc	meekc	PROPN
admet-491	26	7	is	be	AUX
admet-491	26	8	a	a	DET
admet-491	26	9	very	very	ADV
admet-491	26	10	robust	robust	ADJ
admet-491	26	11	technique	technique	NOUN
admet-491	26	12	for	for	ADP
admet-491	26	13	log	log	PROPN
admet-491	26	14	po	po	PROPN
admet-491	26	15	/	/	SYM
admet-491	26	16	w	w	NOUN
admet-491	26	17	determination	determination	NOUN
admet-491	26	18	,	,	PUNCT
admet-491	26	19	since	since	SCONJ
admet-491	26	20	variations	variation	NOUN
admet-491	26	21	in	in	ADP
admet-491	26	22	the	the	DET
admet-491	26	23	me	me	PROPN
admet-491	26	24	composition	composition	NOUN
admet-491	26	25	(	(	PUNCT
admet-491	26	26	ph	ph	ADJ
admet-491	26	27	,	,	PUNCT
admet-491	26	28	buffer	buffer	NOUN
admet-491	26	29	nature	nature	NOUN
admet-491	26	30	,	,	PUNCT
admet-491	26	31	surfactant	surfactant	ADJ
admet-491	26	32	type	type	NOUN
admet-491	26	33	and	and	CCONJ
admet-491	26	34	concentration	concentration	NOUN
admet-491	26	35	,	,	PUNCT
admet-491	26	36	and	and	CCONJ
admet-491	26	37	even	even	ADV
admet-491	26	38	the	the	DET
admet-491	26	39	addition	addition	NOUN
admet-491	26	40	of	of	ADP
admet-491	26	41	organic	organic	ADJ
admet-491	26	42	modifiers	modifier	NOUN
admet-491	26	43	)	)	PUNCT
admet-491	27	1	[	[	X
admet-491	27	2	14	14	NUM
admet-491	27	3	]	]	PUNCT
admet-491	27	4	were	be	AUX
admet-491	27	5	shown	show	VERB
admet-491	27	6	to	to	PART
admet-491	27	7	produce	produce	VERB
admet-491	27	8	insignificant	insignificant	ADJ
admet-491	27	9	changes	change	NOUN
admet-491	27	10	in	in	ADP
admet-491	27	11	its	its	PRON
admet-491	27	12	predictive	predictive	ADJ
admet-491	27	13	capacity	capacity	NOUN
admet-491	27	14	.	.	PUNCT
admet-491	28	1	in	in	ADP
admet-491	28	2	2000	2000	NUM
admet-491	28	3	poole	poole	NOUN
admet-491	28	4	and	and	CCONJ
admet-491	28	5	co	co	NOUN
admet-491	28	6	-	-	NOUN
admet-491	28	7	workers	worker	NOUN
admet-491	28	8	[	[	X
admet-491	28	9	16	16	NUM
admet-491	28	10	]	]	PUNCT
admet-491	28	11	published	publish	VERB
admet-491	28	12	a	a	DET
admet-491	28	13	study	study	NOUN
admet-491	28	14	about	about	ADP
admet-491	28	15	lipophilicity	lipophilicity	NOUN
admet-491	28	16	determination	determination	NOUN
admet-491	28	17	by	by	ADP
admet-491	28	18	meekc	meekc	NOUN
admet-491	28	19	that	that	PRON
admet-491	28	20	included	include	VERB
admet-491	28	21	acidic	acidic	ADJ
admet-491	28	22	compounds	compound	NOUN
admet-491	28	23	using	use	VERB
admet-491	28	24	a	a	DET
admet-491	28	25	running	running	NOUN
admet-491	28	26	buffer	buffer	NOUN
admet-491	28	27	of	of	ADP
admet-491	28	28	ph	ph	ADJ
admet-491	28	29	3	3	NUM
admet-491	28	30	,	,	PUNCT
admet-491	28	31	and	and	CCONJ
admet-491	28	32	employing	employ	VERB
admet-491	28	33	sulfonated	sulfonate	VERB
admet-491	28	34	silica	silica	NOUN
admet-491	28	35	capillaries	capillary	NOUN
admet-491	28	36	in	in	ADP
admet-491	28	37	order	order	NOUN
admet-491	28	38	to	to	PART
admet-491	28	39	provide	provide	VERB
admet-491	28	40	an	an	DET
admet-491	28	41	adequate	adequate	ADJ
admet-491	28	42	electroosmotic	electroosmotic	ADJ
admet-491	28	43	flow	flow	NOUN
admet-491	28	44	at	at	ADP
admet-491	28	45	such	such	DET
admet-491	28	46	an	an	DET
admet-491	28	47	acidic	acidic	ADJ
admet-491	28	48	ph	ph	NOUN
admet-491	28	49	.	.	NOUN
admet-491	28	50	in	in	ADP
admet-491	28	51	a	a	DET
admet-491	28	52	previous	previous	ADJ
admet-491	28	53	study	study	NOUN
admet-491	28	54	involving	involve	VERB
admet-491	28	55	buffers	buffer	NOUN
admet-491	28	56	over	over	ADP
admet-491	28	57	a	a	DET
admet-491	28	58	wide	wide	ADJ
admet-491	28	59	range	range	NOUN
admet-491	28	60	of	of	ADP
admet-491	28	61	ph	ph	ADJ
admet-491	28	62	values	value	NOUN
admet-491	28	63	[	[	X
admet-491	28	64	14	14	NUM
admet-491	28	65	]	]	PUNCT
admet-491	28	66	,	,	PUNCT
admet-491	28	67	we	we	PRON
admet-491	28	68	proposed	propose	VERB
admet-491	28	69	a	a	DET
admet-491	28	70	seminal	seminal	ADJ
admet-491	28	71	pressure	pressure	NOUN
admet-491	28	72	-	-	PUNCT
admet-491	28	73	assisted	assist	VERB
admet-491	28	74	method	method	NOUN
admet-491	28	75	with	with	ADP
admet-491	28	76	reversed	reverse	VERB
admet-491	28	77	polarity	polarity	NOUN
admet-491	28	78	allowing	allow	VERB
admet-491	28	79	measurements	measurement	NOUN
admet-491	28	80	to	to	PART
admet-491	28	81	be	be	AUX
admet-491	28	82	made	make	VERB
admet-491	28	83	at	at	ADP
admet-491	28	84	ph	ph	PROPN
admet-491	28	85	2	2	NUM
admet-491	28	86	and	and	CCONJ
admet-491	28	87	using	use	VERB
admet-491	28	88	conventional	conventional	ADJ
admet-491	28	89	uncoated	uncoated	ADJ
admet-491	28	90	fused	fuse	VERB
admet-491	28	91	silica	silica	NOUN
admet-491	28	92	capillaries	capillary	NOUN
admet-491	28	93	,	,	PUNCT
admet-491	28	94	which	which	PRON
admet-491	28	95	are	be	AUX
admet-491	28	96	much	much	ADV
admet-491	28	97	less	less	ADV
admet-491	28	98	expensive	expensive	ADJ
admet-491	28	99	than	than	ADP
admet-491	28	100	the	the	DET
admet-491	28	101	sulfonic	sulfonic	ADJ
admet-491	28	102	acid	acid	NOUN
admet-491	28	103	coated	coated	ADJ
admet-491	28	104	capillaries	capillary	NOUN
admet-491	28	105	.	.	PUNCT
admet-491	29	1	in	in	ADP
admet-491	29	2	this	this	DET
admet-491	29	3	paper	paper	NOUN
admet-491	29	4	,	,	PUNCT
admet-491	29	5	a	a	DET
admet-491	29	6	systematic	systematic	ADJ
admet-491	29	7	study	study	NOUN
admet-491	29	8	of	of	ADP
admet-491	29	9	structurally	structurally	ADV
admet-491	29	10	diverse	diverse	ADJ
admet-491	29	11	compounds	compound	NOUN
admet-491	29	12	is	be	AUX
admet-491	29	13	presented	present	VERB
admet-491	29	14	,	,	PUNCT
admet-491	29	15	proposing	propose	VERB
admet-491	29	16	a	a	DET
admet-491	29	17	high	high	ADJ
admet-491	29	18	-	-	PUNCT
admet-491	29	19	throughput	throughput	NOUN
admet-491	29	20	validated	validate	VERB
admet-491	29	21	method	method	NOUN
admet-491	29	22	for	for	ADP
admet-491	29	23	the	the	DET
admet-491	29	24	lipophilicity	lipophilicity	NOUN
admet-491	29	25	determination	determination	NOUN
admet-491	29	26	of	of	ADP
admet-491	29	27	acids	acid	NOUN
admet-491	29	28	with	with	ADP
admet-491	29	29	pka	pka	PROPN
admet-491	29	30	values	value	NOUN
admet-491	29	31	as	as	ADV
admet-491	29	32	low	low	ADJ
admet-491	29	33	as	as	ADP
admet-491	29	34	3.5	3.5	NUM
admet-491	29	35	.	.	PUNCT
admet-491	30	1	the	the	DET
admet-491	30	2	partition	partition	NOUN
admet-491	30	3	of	of	ADP
admet-491	30	4	analytes	analyte	NOUN
admet-491	30	5	between	between	ADP
admet-491	30	6	the	the	DET
admet-491	30	7	aqueous	aqueous	ADJ
admet-491	30	8	bulk	bulk	ADJ
admet-491	30	9	solvent	solvent	NOUN
admet-491	30	10	and	and	CCONJ
admet-491	30	11	the	the	DET
admet-491	30	12	pseudo	pseudo	NOUN
admet-491	30	13	-	-	ADJ
admet-491	30	14	stationary	stationary	ADJ
admet-491	30	15	oil	oil	NOUN
admet-491	30	16	phase	phase	NOUN
admet-491	30	17	in	in	ADP
admet-491	30	18	the	the	DET
admet-491	30	19	me	i	PRON
admet-491	30	20	is	be	AUX
admet-491	30	21	measured	measure	VERB
admet-491	30	22	by	by	ADP
admet-491	30	23	the	the	DET
admet-491	30	24	logarithm	logarithm	NOUN
admet-491	30	25	of	of	ADP
admet-491	30	26	the	the	DET
admet-491	30	27	mass	mass	ADJ
admet-491	30	28	distribution	distribution	NOUN
admet-491	30	29	ratio	ratio	NOUN
admet-491	30	30	(	(	PUNCT
admet-491	30	31	log	log	PROPN
admet-491	30	32	kmeekc	kmeekc	PROPN
admet-491	30	33	)	)	PUNCT
admet-491	31	1	[	[	X
admet-491	31	2	17	17	NUM
admet-491	31	3	]	]	SYM
admet-491	31	4	:	:	PUNCT
admet-491	31	5			NOUN
admet-491	31	6	r	r	NOUN
admet-491	31	7	me	i	PRON
admet-491	31	8	r	r	NOUN
admet-491	31	9	eof	eof	PROPN
admet-491	31	10	meekc	meekc	NOUN
admet-491	31	11	eof	eof	PROPN
admet-491	31	12	log	log	NOUN
admet-491	31	13	log	log	NOUN
admet-491	31	14	1	1	NUM
admet-491	31	15	t	t	NOUN
admet-491	31	16	t	t	PROPN
admet-491	31	17	t	t	PROPN
admet-491	31	18	t	t	PROPN
admet-491	32	1	k	k	PROPN
admet-491	32	2	t	t	PROPN
admet-491	32	3			PROPN
admet-491	32	4			PROPN
admet-491	32	5			NOUN
admet-491	32	6	(	(	PUNCT
admet-491	32	7	1	1	NUM
admet-491	32	8	)	)	PUNCT
admet-491	32	9	admet	admet	PROPN
admet-491	32	10	&	&	CCONJ
admet-491	32	11	dmpk	dmpk	PROPN
admet-491	32	12	6(2	6(2	NUM
admet-491	32	13	)	)	PUNCT
admet-491	32	14	(	(	PUNCT
admet-491	32	15	2018	2018	NUM
admet-491	32	16	)	)	PUNCT
admet-491	32	17	153	153	NUM
admet-491	32	18	-	-	SYM
admet-491	32	19	161	161	NUM
admet-491	32	20	lipophylicity	lipophylicity	NOUN
admet-491	32	21	determination	determination	NOUN
admet-491	32	22	of	of	ADP
admet-491	32	23	acidic	acidic	ADJ
admet-491	32	24	compounds	compound	NOUN
admet-491	32	25	by	by	ADP
admet-491	32	26	meekc	meekc	ADJ
admet-491	32	27	doi	doi	PROPN
admet-491	32	28	:	:	PUNCT
admet-491	32	29	10.5599	10.5599	NUM
admet-491	32	30	/	/	SYM
admet-491	32	31	admet.491	admet.491	PROPN
admet-491	32	32	155	155	NUM
admet-491	32	33	where	where	SCONJ
admet-491	32	34	tr	tr	VERB
admet-491	32	35	and	and	CCONJ
admet-491	32	36	teof	teof	NOUN
admet-491	32	37	are	be	AUX
admet-491	32	38	the	the	DET
admet-491	32	39	migration	migration	NOUN
admet-491	32	40	times	time	NOUN
admet-491	32	41	of	of	ADP
admet-491	32	42	the	the	DET
admet-491	32	43	analyte	analyte	NOUN
admet-491	32	44	and	and	CCONJ
admet-491	32	45	the	the	DET
admet-491	32	46	electroosmotic	electroosmotic	ADJ
admet-491	32	47	flow	flow	NOUN
admet-491	32	48	(	(	PUNCT
admet-491	32	49	eof	eof	NOUN
admet-491	32	50	)	)	PUNCT
admet-491	32	51	marker	marker	NOUN
admet-491	32	52	(	(	PUNCT
admet-491	32	53	e.g.	e.g.	ADV
admet-491	32	54	dmso	dmso	NOUN
admet-491	32	55	)	)	PUNCT
admet-491	32	56	,	,	PUNCT
admet-491	32	57	respectively	respectively	ADV
admet-491	32	58	,	,	PUNCT
admet-491	32	59	and	and	CCONJ
admet-491	32	60	tme	tme	X
admet-491	32	61	is	be	AUX
admet-491	32	62	the	the	DET
admet-491	32	63	migration	migration	NOUN
admet-491	32	64	time	time	NOUN
admet-491	32	65	of	of	ADP
admet-491	32	66	a	a	DET
admet-491	32	67	very	very	ADV
admet-491	32	68	lipophilic	lipophilic	ADJ
admet-491	32	69	compound	compound	NOUN
admet-491	32	70	used	use	VERB
admet-491	32	71	as	as	ADP
admet-491	32	72	me	i	PRON
admet-491	32	73	marker	marker	NOUN
admet-491	32	74	(	(	PUNCT
admet-491	32	75	e.g.	e.g.	ADV
admet-491	32	76	dodecanophenone	dodecanophenone	NOUN
admet-491	32	77	)	)	PUNCT
admet-491	32	78	.	.	PUNCT
admet-491	33	1	thus	thus	ADV
admet-491	33	2	,	,	PUNCT
admet-491	33	3	log	log	PROPN
admet-491	33	4	kmeekc	kmeekc	PROPN
admet-491	33	5	values	value	NOUN
admet-491	33	6	obtained	obtain	VERB
admet-491	33	7	for	for	ADP
admet-491	33	8	unionized	unionized	ADJ
admet-491	33	9	species	specie	NOUN
admet-491	33	10	can	can	AUX
admet-491	33	11	be	be	AUX
admet-491	33	12	used	use	VERB
admet-491	33	13	to	to	PART
admet-491	33	14	estimate	estimate	VERB
admet-491	33	15	their	their	PRON
admet-491	33	16	lipophilicity	lipophilicity	NOUN
admet-491	33	17	according	accord	VERB
admet-491	33	18	to	to	ADP
admet-491	33	19	the	the	DET
admet-491	33	20	following	follow	VERB
admet-491	33	21	linear	linear	PROPN
admet-491	33	22	equation	equation	NOUN
admet-491	33	23	:	:	PUNCT
admet-491	33	24	o	o	NOUN
admet-491	33	25	/	/	SYM
admet-491	33	26	w	w	PROPN
admet-491	33	27	meekclog	meekclog	PROPN
admet-491	33	28	·	·	PUNCT
admet-491	33	29	logp	logp	NOUN
admet-491	33	30	a	a	DET
admet-491	33	31	k	k	PROPN
admet-491	33	32	b	b	PROPN
admet-491	33	33			X
admet-491	33	34	(	(	PUNCT
admet-491	33	35	2	2	NUM
admet-491	33	36	)	)	PUNCT
admet-491	33	37	where	where	SCONJ
admet-491	33	38	a	a	PRON
admet-491	33	39	and	and	CCONJ
admet-491	33	40	b	b	NOUN
admet-491	33	41	are	be	AUX
admet-491	33	42	the	the	DET
admet-491	33	43	slope	slope	NOUN
admet-491	33	44	and	and	CCONJ
admet-491	33	45	intercept	intercept	NOUN
admet-491	33	46	,	,	PUNCT
admet-491	33	47	respectively	respectively	ADV
admet-491	33	48	,	,	PUNCT
admet-491	33	49	of	of	ADP
admet-491	33	50	the	the	DET
admet-491	33	51	linear	linear	ADJ
admet-491	33	52	regression	regression	NOUN
admet-491	33	53	calculated	calculate	VERB
admet-491	33	54	by	by	ADP
admet-491	33	55	the	the	DET
admet-491	33	56	least	least	ADJ
admet-491	33	57	square	square	ADJ
admet-491	33	58	method	method	NOUN
admet-491	33	59	.	.	PUNCT
admet-491	34	1	internal	internal	ADJ
admet-491	34	2	and	and	CCONJ
admet-491	34	3	external	external	ADJ
admet-491	34	4	validation	validation	NOUN
admet-491	34	5	of	of	ADP
admet-491	34	6	the	the	DET
admet-491	34	7	method	method	NOUN
admet-491	34	8	the	the	DET
admet-491	34	9	ability	ability	NOUN
admet-491	34	10	of	of	ADP
admet-491	34	11	the	the	DET
admet-491	34	12	model	model	NOUN
admet-491	34	13	to	to	PART
admet-491	34	14	reproduce	reproduce	VERB
admet-491	34	15	the	the	DET
admet-491	34	16	data	datum	NOUN
admet-491	34	17	included	include	VERB
admet-491	34	18	in	in	ADP
admet-491	34	19	the	the	DET
admet-491	34	20	set	set	NOUN
admet-491	34	21	of	of	ADP
admet-491	34	22	compounds	compound	NOUN
admet-491	34	23	(	(	PUNCT
admet-491	34	24	the	the	DET
admet-491	34	25	goodness	goodness	NOUN
admet-491	34	26	-	-	PUNCT
admet-491	34	27	of	of	ADP
admet-491	34	28	-	-	PUNCT
admet-491	34	29	fit	fit	NOUN
admet-491	34	30	)	)	PUNCT
admet-491	34	31	is	be	AUX
admet-491	34	32	measured	measure	VERB
admet-491	34	33	by	by	ADP
admet-491	34	34	the	the	DET
admet-491	34	35	determination	determination	NOUN
admet-491	34	36	coefficient	coefficient	NOUN
admet-491	34	37	of	of	ADP
admet-491	34	38	the	the	DET
admet-491	34	39	model	model	NOUN
admet-491	34	40	(	(	PUNCT
admet-491	34	41	r2	r2	PROPN
admet-491	34	42	)	)	PUNCT
admet-491	34	43	,	,	PUNCT
admet-491	34	44	which	which	PRON
admet-491	34	45	in	in	ADP
admet-491	34	46	our	our	PRON
admet-491	34	47	case	case	NOUN
admet-491	34	48	estimates	estimate	VERB
admet-491	34	49	the	the	DET
admet-491	34	50	proportion	proportion	NOUN
admet-491	34	51	of	of	ADP
admet-491	34	52	the	the	DET
admet-491	34	53	variation	variation	NOUN
admet-491	34	54	in	in	ADP
admet-491	34	55	the	the	DET
admet-491	34	56	predicted	predict	VERB
admet-491	34	57	log	log	NOUN
admet-491	34	58	po	po	NOUN
admet-491	34	59	/	/	SYM
admet-491	34	60	w	w	NOUN
admet-491	34	61	that	that	PRON
admet-491	34	62	can	can	AUX
admet-491	34	63	be	be	AUX
admet-491	34	64	explained	explain	VERB
admet-491	34	65	according	accord	VERB
admet-491	34	66	to	to	ADP
admet-491	34	67	the	the	DET
admet-491	34	68	model	model	NOUN
admet-491	34	69	.	.	PUNCT
admet-491	35	1	the	the	DET
admet-491	35	2	robustness	robustness	NOUN
admet-491	35	3	of	of	ADP
admet-491	35	4	the	the	DET
admet-491	35	5	model	model	NOUN
admet-491	35	6	can	can	AUX
admet-491	35	7	be	be	AUX
admet-491	35	8	assessed	assess	VERB
admet-491	35	9	by	by	ADP
admet-491	35	10	cross	cross	NOUN
admet-491	35	11	-	-	NOUN
admet-491	35	12	validation	validation	NOUN
admet-491	35	13	,	,	PUNCT
admet-491	35	14	in	in	ADP
admet-491	35	15	which	which	PRON
admet-491	35	16	a	a	DET
admet-491	35	17	number	number	NOUN
admet-491	35	18	of	of	ADP
admet-491	35	19	compounds	compound	NOUN
admet-491	35	20	are	be	AUX
admet-491	35	21	iteratively	iteratively	ADV
admet-491	35	22	excluded	exclude	VERB
admet-491	35	23	from	from	ADP
admet-491	35	24	the	the	DET
admet-491	35	25	set	set	NOUN
admet-491	35	26	of	of	ADP
admet-491	35	27	substances	substance	NOUN
admet-491	35	28	used	use	VERB
admet-491	35	29	for	for	ADP
admet-491	35	30	model	model	NOUN
admet-491	35	31	development	development	NOUN
admet-491	35	32	and	and	CCONJ
admet-491	35	33	the	the	DET
admet-491	35	34	results	result	NOUN
admet-491	35	35	then	then	ADV
admet-491	35	36	allow	allow	VERB
admet-491	35	37	the	the	DET
admet-491	35	38	prediction	prediction	NOUN
admet-491	35	39	to	to	PART
admet-491	35	40	be	be	AUX
admet-491	35	41	made	make	VERB
admet-491	35	42	for	for	ADP
admet-491	35	43	the	the	DET
admet-491	35	44	left	leave	VERB
admet-491	35	45	-	-	PUNCT
admet-491	35	46	out	out	ADP
admet-491	35	47	compounds	compound	NOUN
admet-491	35	48	.	.	PUNCT
admet-491	36	1	thus	thus	ADV
admet-491	36	2	,	,	PUNCT
admet-491	36	3	the	the	DET
admet-491	36	4	cross	cross	ADJ
admet-491	36	5	-	-	ADJ
admet-491	36	6	validated	validated	ADJ
admet-491	36	7	correlation	correlation	NOUN
admet-491	36	8	coefficient	coefficient	NOUN
admet-491	36	9	(	(	PUNCT
admet-491	36	10	q2	q2	NOUN
admet-491	36	11	)	)	PUNCT
admet-491	36	12	,	,	PUNCT
admet-491	36	13	which	which	PRON
admet-491	36	14	is	be	AUX
admet-491	36	15	a	a	DET
admet-491	36	16	measure	measure	NOUN
admet-491	36	17	of	of	ADP
admet-491	36	18	the	the	DET
admet-491	36	19	goodness	goodness	NOUN
admet-491	36	20	of	of	ADP
admet-491	36	21	the	the	DET
admet-491	36	22	internal	internal	ADJ
admet-491	36	23	power	power	NOUN
admet-491	36	24	to	to	PART
admet-491	36	25	predict	predict	VERB
admet-491	36	26	,	,	PUNCT
admet-491	36	27	can	can	AUX
admet-491	36	28	be	be	AUX
admet-491	36	29	calculated	calculate	VERB
admet-491	36	30	by	by	ADP
admet-491	36	31	the	the	DET
admet-491	36	32	formula	formula	NOUN
admet-491	36	33	:	:	PUNCT
admet-491	36	34			NOUN
admet-491	36	35			SYM
admet-491	36	36			NOUN
admet-491	36	37			PROPN
admet-491	36	38	2	2	NUM
admet-491	37	1	i	i	PRON
admet-491	37	2	i	i	PRON
admet-491	37	3	/	/	SYM
admet-491	37	4	i	i	NOUN
admet-491	37	5	2	2	NUM
admet-491	37	6	1	1	NUM
admet-491	37	7	2	2	NUM
admet-491	37	8	i	i	NOUN
admet-491	37	9	1	1	NUM
admet-491	37	10	ˆ	ˆ	NOUN
admet-491	37	11	1	1	NUM
admet-491	37	12	n	n	NOUN
admet-491	37	13	i	i	PRON
admet-491	37	14	n	n	VERB
admet-491	38	1	i	i	PRON
admet-491	38	2	y	y	VERB
admet-491	38	3	y	y	INTJ
admet-491	38	4	q	q	PROPN
admet-491	38	5	y	y	PROPN
admet-491	38	6	y	y	PROPN
admet-491	39	1			PROPN
admet-491	39	2			PROPN
admet-491	39	3			PROPN
admet-491	39	4			PROPN
admet-491	39	5			PROPN
admet-491	39	6			PROPN
admet-491	39	7			X
admet-491	39	8			X
admet-491	39	9	(	(	PUNCT
admet-491	39	10	3	3	X
admet-491	39	11	)	)	PUNCT
admet-491	39	12	where	where	SCONJ
admet-491	39	13	iy	iy	PROPN
admet-491	39	14	is	be	AUX
admet-491	39	15	the	the	DET
admet-491	39	16	observed	observed	ADJ
admet-491	39	17	response	response	NOUN
admet-491	39	18	(	(	PUNCT
admet-491	39	19	literature	literature	NOUN
admet-491	39	20	log	log	NOUN
admet-491	39	21	po	po	PROPN
admet-491	39	22	/	/	SYM
admet-491	39	23	w	w	PROPN
admet-491	39	24	)	)	PUNCT
admet-491	39	25	for	for	ADP
admet-491	39	26	the	the	DET
admet-491	39	27	ith	ith	PROPN
admet-491	39	28	object	object	NOUN
admet-491	39	29	,	,	PUNCT
admet-491	39	30	/ˆi	/ˆi	PUNCT
admet-491	39	31	iy	iy	PROPN
admet-491	39	32	is	be	AUX
admet-491	39	33	the	the	DET
admet-491	39	34	response	response	NOUN
admet-491	39	35	of	of	ADP
admet-491	39	36	the	the	DET
admet-491	39	37	ith	ith	PROPN
admet-491	39	38	object	object	NOUN
admet-491	39	39	estimated	estimate	VERB
admet-491	39	40	by	by	ADP
admet-491	39	41	the	the	DET
admet-491	39	42	model	model	NOUN
admet-491	39	43	obtained	obtain	VERB
admet-491	39	44	without	without	ADP
admet-491	39	45	using	use	VERB
admet-491	39	46	the	the	DET
admet-491	39	47	ith	ith	ADJ
admet-491	39	48	object	object	NOUN
admet-491	39	49	(	(	PUNCT
admet-491	39	50	log	log	VERB
admet-491	39	51	po	po	NOUN
admet-491	39	52	/	/	SYM
admet-491	39	53	w	w	PROPN
admet-491	39	54	from	from	ADP
admet-491	39	55	log	log	PROPN
admet-491	39	56	kmeekc	kmeekc	PROPN
admet-491	39	57	measurements	measurement	NOUN
admet-491	39	58	)	)	PUNCT
admet-491	39	59	,	,	PUNCT
admet-491	39	60	and	and	CCONJ
admet-491	39	61	y	y	PROPN
admet-491	39	62	is	be	AUX
admet-491	39	63	the	the	DET
admet-491	39	64	mean	mean	ADJ
admet-491	39	65	value	value	NOUN
admet-491	39	66	of	of	ADP
admet-491	39	67	observed	observed	ADJ
admet-491	39	68	responses	response	NOUN
admet-491	39	69	for	for	ADP
admet-491	39	70	the	the	DET
admet-491	39	71	n	n	PRON
admet-491	39	72	elements	element	NOUN
admet-491	39	73	of	of	ADP
admet-491	39	74	the	the	DET
admet-491	39	75	complete	complete	ADJ
admet-491	39	76	data	datum	NOUN
admet-491	39	77	set	set	VERB
admet-491	39	78	.	.	PUNCT
admet-491	40	1	the	the	DET
admet-491	40	2	size	size	NOUN
admet-491	40	3	of	of	ADP
admet-491	40	4	the	the	DET
admet-491	40	5	group	group	NOUN
admet-491	40	6	of	of	ADP
admet-491	40	7	excluded	exclude	VERB
admet-491	40	8	chemicals	chemical	NOUN
admet-491	40	9	at	at	ADP
admet-491	40	10	every	every	DET
admet-491	40	11	step	step	NOUN
admet-491	40	12	is	be	AUX
admet-491	40	13	normally	normally	ADV
admet-491	40	14	in	in	ADP
admet-491	40	15	the	the	DET
admet-491	40	16	range	range	NOUN
admet-491	40	17	of	of	ADP
admet-491	40	18	only	only	ADV
admet-491	40	19	one	one	NUM
admet-491	40	20	(	(	PUNCT
admet-491	40	21	leave	leave	VERB
admet-491	40	22	-	-	PUNCT
admet-491	40	23	one	one	NUM
admet-491	40	24	-	-	PUNCT
admet-491	40	25	out	out	NOUN
admet-491	40	26	,	,	PUNCT
admet-491	40	27	loo	loo	NOUN
admet-491	40	28	)	)	PUNCT
admet-491	40	29	to	to	ADP
admet-491	40	30	50	50	NUM
admet-491	40	31	%	%	NOUN
admet-491	40	32	of	of	ADP
admet-491	40	33	the	the	DET
admet-491	40	34	whole	whole	ADJ
admet-491	40	35	set	set	NOUN
admet-491	40	36	of	of	ADP
admet-491	40	37	compounds	compound	NOUN
admet-491	40	38	(	(	PUNCT
admet-491	40	39	leave	leave	VERB
admet-491	40	40	-	-	PUNCT
admet-491	40	41	many	many	ADJ
admet-491	40	42	-	-	PUNCT
admet-491	40	43	out	out	NOUN
admet-491	40	44	,	,	PUNCT
admet-491	40	45	lmo	lmo	PROPN
admet-491	40	46	)	)	PUNCT
admet-491	40	47	.	.	PUNCT
admet-491	41	1	high	high	ADJ
admet-491	41	2	mean	mean	PROPN
admet-491	41	3	q2	q2	NOUN
admet-491	41	4	values	value	NOUN
admet-491	41	5	in	in	ADP
admet-491	41	6	loo	loo	PROPN
admet-491	41	7	(	(	PUNCT
admet-491	41	8	q2	q2	NOUN
admet-491	41	9	loo	loo	NOUN
admet-491	41	10	)	)	PUNCT
admet-491	41	11	and	and	CCONJ
admet-491	41	12	lmo	lmo	PROPN
admet-491	41	13	(	(	PUNCT
admet-491	41	14	q2	q2	PROPN
admet-491	41	15	lmo	lmo	PROPN
admet-491	41	16	)	)	PUNCT
admet-491	41	17	validations	validation	NOUN
admet-491	41	18	(	(	PUNCT
admet-491	41	19	>	>	X
admet-491	41	20	0.7	0.7	NUM
admet-491	41	21	)	)	PUNCT
admet-491	41	22	are	be	AUX
admet-491	41	23	necessary	necessary	ADJ
admet-491	41	24	but	but	CCONJ
admet-491	41	25	are	be	AUX
admet-491	41	26	not	not	PART
admet-491	41	27	sufficient	sufficient	ADJ
admet-491	41	28	conditions	condition	NOUN
admet-491	41	29	for	for	SCONJ
admet-491	41	30	a	a	DET
admet-491	41	31	model	model	NOUN
admet-491	41	32	to	to	PART
admet-491	41	33	be	be	AUX
admet-491	41	34	robust	robust	ADJ
admet-491	41	35	and	and	CCONJ
admet-491	41	36	internally	internally	ADV
admet-491	41	37	predictive	predictive	ADJ
admet-491	41	38	[	[	X
admet-491	41	39	18	18	NUM
admet-491	41	40	]	]	PUNCT
admet-491	41	41	.	.	PUNCT
admet-491	42	1	the	the	DET
admet-491	42	2	external	external	ADJ
admet-491	42	3	validation	validation	NOUN
admet-491	42	4	is	be	AUX
admet-491	42	5	performed	perform	VERB
admet-491	42	6	by	by	ADP
admet-491	42	7	splitting	split	VERB
admet-491	42	8	the	the	DET
admet-491	42	9	whole	whole	ADJ
admet-491	42	10	data	datum	NOUN
admet-491	42	11	set	set	VERB
admet-491	42	12	into	into	ADP
admet-491	42	13	two	two	NUM
admet-491	42	14	different	different	ADJ
admet-491	42	15	sets	set	NOUN
admet-491	42	16	,	,	PUNCT
admet-491	42	17	a	a	DET
admet-491	42	18	training	training	NOUN
admet-491	42	19	set	set	NOUN
admet-491	42	20	used	use	VERB
admet-491	42	21	for	for	ADP
admet-491	42	22	method	method	NOUN
admet-491	42	23	development	development	NOUN
admet-491	42	24	and	and	CCONJ
admet-491	42	25	a	a	DET
admet-491	42	26	test	test	NOUN
admet-491	42	27	set	set	VERB
admet-491	42	28	for	for	ADP
admet-491	42	29	the	the	DET
admet-491	42	30	assessment	assessment	NOUN
admet-491	42	31	of	of	ADP
admet-491	42	32	the	the	DET
admet-491	42	33	predictive	predictive	ADJ
admet-491	42	34	capacity	capacity	NOUN
admet-491	42	35	.	.	PUNCT
admet-491	43	1	predicted	predict	VERB
admet-491	43	2	values	value	NOUN
admet-491	43	3	are	be	AUX
admet-491	43	4	correlated	correlate	VERB
admet-491	43	5	with	with	ADP
admet-491	43	6	the	the	DET
admet-491	43	7	experimental	experimental	ADJ
admet-491	43	8	ones	one	NOUN
admet-491	43	9	,	,	PUNCT
admet-491	43	10	and	and	CCONJ
admet-491	43	11	the	the	DET
admet-491	43	12	linear	linear	ADJ
admet-491	43	13	regression	regression	NOUN
admet-491	43	14	is	be	AUX
admet-491	43	15	expected	expect	VERB
admet-491	43	16	to	to	PART
admet-491	43	17	be	be	AUX
admet-491	43	18	as	as	ADV
admet-491	43	19	close	close	ADJ
admet-491	43	20	as	as	ADP
admet-491	43	21	possible	possible	ADJ
admet-491	43	22	to	to	ADP
admet-491	43	23	that	that	PRON
admet-491	43	24	of	of	ADP
admet-491	43	25	unity	unity	NOUN
admet-491	43	26	slope	slope	NOUN
admet-491	43	27	and	and	CCONJ
admet-491	43	28	null	null	ADJ
admet-491	43	29	intercept	intercept	NOUN
admet-491	43	30	.	.	PUNCT
admet-491	44	1	this	this	DET
admet-491	44	2	closeness	closeness	NOUN
admet-491	44	3	can	can	AUX
admet-491	44	4	be	be	AUX
admet-491	44	5	calculated	calculate	VERB
admet-491	44	6	as	as	ADP
admet-491	44	7	(	(	PUNCT
admet-491	44	8	r2	r2	NOUN
admet-491	44	9	-	-	PUNCT
admet-491	44	10	r0	r0	NOUN
admet-491	44	11	2)/r2	2)/r2	NUM
admet-491	44	12	[	[	X
admet-491	44	13	19	19	NUM
admet-491	44	14	]	]	PUNCT
admet-491	44	15	,	,	PUNCT
admet-491	44	16	where	where	SCONJ
admet-491	44	17	r0	r0	NOUN
admet-491	44	18	2	2	NUM
admet-491	44	19	is	be	AUX
admet-491	44	20	the	the	DET
admet-491	44	21	determination	determination	NOUN
admet-491	44	22	coefficient	coefficient	NOUN
admet-491	44	23	of	of	ADP
admet-491	44	24	the	the	DET
admet-491	44	25	regression	regression	NOUN
admet-491	44	26	line	line	NOUN
admet-491	44	27	forced	force	VERB
admet-491	44	28	to	to	PART
admet-491	44	29	pass	pass	VERB
admet-491	44	30	through	through	ADP
admet-491	44	31	the	the	DET
admet-491	44	32	origin	origin	NOUN
admet-491	44	33	,	,	PUNCT
admet-491	44	34	or	or	CCONJ
admet-491	44	35	by	by	ADP
admet-491	44	36	means	mean	NOUN
admet-491	44	37	of	of	ADP
admet-491	44	38	the	the	DET
admet-491	44	39	concordance	concordance	NOUN
admet-491	44	40	correlation	correlation	NOUN
admet-491	44	41	coefficient	coefficient	NOUN
admet-491	44	42	(	(	PUNCT
admet-491	44	43	ccc	ccc	X
admet-491	44	44	)	)	PUNCT
admet-491	45	1	[	[	X
admet-491	45	2	20	20	NUM
admet-491	45	3	]	]	PUNCT
admet-491	45	4	,	,	PUNCT
admet-491	45	5	which	which	PRON
admet-491	45	6	can	can	AUX
admet-491	45	7	be	be	AUX
admet-491	45	8	calculated	calculate	VERB
admet-491	45	9	by	by	ADP
admet-491	45	10	the	the	DET
admet-491	45	11	formula	formula	NOUN
admet-491	45	12	:	:	PUNCT
admet-491	45	13			PROPN
admet-491	45	14			NOUN
admet-491	46	1			PROPN
admet-491	46	2			NOUN
admet-491	46	3			SYM
admet-491	46	4			NOUN
admet-491	46	5			SYM
admet-491	46	6			NOUN
admet-491	46	7			PUNCT
admet-491	47	1	i	i	PRON
admet-491	47	2	i	i	VERB
admet-491	47	3	1	1	NUM
admet-491	47	4	2	2	NUM
admet-491	47	5	2	2	NUM
admet-491	47	6	2	2	NUM
admet-491	47	7	i	i	PRON
admet-491	47	8	i	i	VERB
admet-491	47	9	1	1	NUM
admet-491	47	10	1	1	NUM
admet-491	47	11	2	2	NUM
admet-491	47	12	1	1	NUM
admet-491	47	13	n	n	NOUN
admet-491	47	14	i	i	PRON
admet-491	47	15	n	n	VERB
admet-491	47	16	n	n	NOUN
admet-491	47	17	i	i	PRON
admet-491	47	18	i	i	INTJ
admet-491	47	19	x	x	VERB
admet-491	47	20	x	x	VERB
admet-491	47	21	y	y	VERB
admet-491	47	22	y	y	PROPN
admet-491	47	23	ccc	ccc	PROPN
admet-491	47	24	x	x	PUNCT
admet-491	48	1	x	x	PUNCT
admet-491	48	2	y	y	VERB
admet-491	48	3	y	y	PROPN
admet-491	48	4	n	n	INTJ
admet-491	48	5	x	x	SYM
admet-491	48	6	y	y	PROPN
admet-491	48	7			NUM
admet-491	48	8			NUM
admet-491	49	1			PROPN
admet-491	49	2			PROPN
admet-491	49	3			PROPN
admet-491	49	4			PROPN
admet-491	49	5			PROPN
admet-491	49	6			PROPN
admet-491	49	7			PUNCT
admet-491	49	8			PROPN
admet-491	49	9			VERB
admet-491	49	10			X
admet-491	49	11			X
admet-491	49	12			X
admet-491	49	13			X
admet-491	49	14	(	(	PUNCT
admet-491	49	15	4	4	X
admet-491	49	16	)	)	PUNCT
admet-491	49	17	where	where	SCONJ
admet-491	49	18	x	x	PUNCT
admet-491	49	19	and	and	CCONJ
admet-491	49	20	y	y	PROPN
admet-491	49	21	correspond	correspond	VERB
admet-491	49	22	to	to	ADP
admet-491	49	23	the	the	DET
admet-491	49	24	abscissa	abscissa	ADJ
admet-491	49	25	and	and	CCONJ
admet-491	49	26	ordinate	ordinate	VERB
admet-491	49	27	values	value	NOUN
admet-491	49	28	of	of	ADP
admet-491	49	29	the	the	DET
admet-491	49	30	correlation	correlation	NOUN
admet-491	49	31	plot	plot	NOUN
admet-491	49	32	,	,	PUNCT
admet-491	49	33	x	x	PUNCT
admet-491	49	34	and	and	CCONJ
admet-491	49	35	y	y	PROPN
admet-491	49	36	are	be	AUX
admet-491	49	37	mean	mean	VERB
admet-491	49	38	values	value	NOUN
admet-491	49	39	and	and	CCONJ
admet-491	49	40	n	n	PRON
admet-491	49	41	is	be	AUX
admet-491	49	42	the	the	DET
admet-491	49	43	number	number	NOUN
admet-491	49	44	of	of	ADP
admet-491	49	45	compounds	compound	NOUN
admet-491	49	46	in	in	ADP
admet-491	49	47	the	the	DET
admet-491	49	48	test	test	NOUN
admet-491	49	49	set	set	NOUN
admet-491	49	50	.	.	PUNCT
admet-491	50	1	the	the	DET
admet-491	50	2	main	main	ADJ
admet-491	50	3	advantage	advantage	NOUN
admet-491	50	4	of	of	ADP
admet-491	50	5	ccc	ccc	PROPN
admet-491	50	6	is	be	AUX
admet-491	50	7	the	the	DET
admet-491	50	8	independence	independence	NOUN
admet-491	50	9	of	of	ADP
admet-491	50	10	the	the	DET
admet-491	50	11	closeness	closeness	NOUN
admet-491	50	12	value	value	NOUN
admet-491	50	13	in	in	ADP
admet-491	50	14	relation	relation	NOUN
admet-491	50	15	to	to	ADP
admet-491	50	16	the	the	DET
admet-491	50	17	disposition	disposition	NOUN
admet-491	50	18	of	of	ADP
admet-491	50	19	the	the	DET
admet-491	50	20	axes	axis	NOUN
admet-491	50	21	.	.	PUNCT
admet-491	51	1	thus	thus	ADV
admet-491	51	2	,	,	PUNCT
admet-491	51	3	a	a	DET
admet-491	51	4	model	model	NOUN
admet-491	51	5	can	can	AUX
admet-491	51	6	be	be	AUX
admet-491	51	7	assessed	assess	VERB
admet-491	51	8	as	as	ADP
admet-491	51	9	externally	externally	ADV
admet-491	51	10	predictive	predictive	ADJ
admet-491	51	11	if	if	SCONJ
admet-491	51	12	r2	r2	PROPN
admet-491	51	13	and	and	CCONJ
admet-491	51	14	r0	r0	PROPN
admet-491	51	15	2	2	NUM
admet-491	51	16	are	be	AUX
admet-491	51	17	close	close	ADJ
admet-491	51	18	to	to	ADP
admet-491	51	19	1	1	NUM
admet-491	51	20	,	,	PUNCT
admet-491	51	21	slopes	slope	NOUN
admet-491	51	22	of	of	ADP
admet-491	51	23	linear	linear	PROPN
admet-491	51	24	regressions	regression	NOUN
admet-491	51	25	are	be	AUX
admet-491	51	26	in	in	ADP
admet-491	51	27	the	the	DET
admet-491	51	28	range	range	NOUN
admet-491	51	29	between	between	ADP
admet-491	51	30	0.85	0.85	NUM
admet-491	51	31	and	and	CCONJ
admet-491	51	32	1.15	1.15	NUM
admet-491	51	33	,	,	PUNCT
admet-491	51	34	and	and	CCONJ
admet-491	51	35	(	(	PUNCT
admet-491	51	36	r2	r2	NOUN
admet-491	51	37	-	-	PUNCT
admet-491	51	38	r0	r0	NOUN
admet-491	51	39	2)/r2	2)/r2	NUM
admet-491	51	40	<	<	X
admet-491	51	41	0.1	0.1	NUM
admet-491	52	1	[	[	X
admet-491	52	2	19	19	NUM
admet-491	52	3	]	]	X
admet-491	52	4	,	,	PUNCT
admet-491	52	5	or	or	CCONJ
admet-491	52	6	alternatively	alternatively	ADV
admet-491	52	7	if	if	SCONJ
admet-491	52	8	ccc	ccc	PROPN
admet-491	52	9	≥	≥	PUNCT
admet-491	52	10	0.85	0.85	NUM
admet-491	52	11	[	[	X
admet-491	52	12	20	20	NUM
admet-491	52	13	]	]	PUNCT
admet-491	52	14	.	.	PUNCT
admet-491	53	1	marti	marti	PROPN
admet-491	53	2	rosés	rosés	PROPN
admet-491	53	3	et	et	PROPN
admet-491	53	4	al	al	PROPN
admet-491	53	5	.	.	PROPN
admet-491	53	6	admet	admet	PROPN
admet-491	53	7	&	&	CCONJ
admet-491	53	8	dmpk	dmpk	PROPN
admet-491	53	9	6(2	6(2	NUM
admet-491	53	10	)	)	PUNCT
admet-491	53	11	(	(	PUNCT
admet-491	53	12	2018	2018	NUM
admet-491	53	13	)	)	PUNCT
admet-491	53	14	153	153	NUM
admet-491	53	15	-	-	SYM
admet-491	53	16	161	161	NUM
admet-491	53	17	156	156	NUM
admet-491	53	18	experimental	experimental	ADJ
admet-491	53	19	instrumentation	instrumentation	NOUN
admet-491	53	20	a	a	DET
admet-491	53	21	g1600	g1600	NOUN
admet-491	53	22	capillary	capillary	ADJ
admet-491	53	23	electrophoresis	electrophoresis	NOUN
admet-491	53	24	(	(	PUNCT
admet-491	53	25	agilent	agilent	PROPN
admet-491	53	26	,	,	PUNCT
admet-491	53	27	waldbronn	waldbronn	NOUN
admet-491	53	28	,	,	PUNCT
admet-491	53	29	germany	germany	PROPN
admet-491	53	30	)	)	PUNCT
admet-491	53	31	with	with	ADP
admet-491	53	32	uv	uv	NOUN
admet-491	53	33	detection	detection	NOUN
admet-491	53	34	and	and	CCONJ
admet-491	53	35	polyimide	polyimide	ADJ
admet-491	53	36	coated	coated	ADJ
admet-491	53	37	capillaries	capillary	NOUN
admet-491	53	38	of	of	ADP
admet-491	53	39	50	50	NUM
admet-491	53	40	μm	μm	NOUN
admet-491	53	41	i	i	PROPN
admet-491	53	42	d	d	PROPN
admet-491	53	43	,	,	PUNCT
admet-491	53	44	375	375	NUM
admet-491	53	45	μm	μm	NOUN
admet-491	53	46	od	od	NOUN
admet-491	53	47	and	and	CCONJ
admet-491	53	48	57.0±0.1/48.5±0.1	57.0±0.1/48.5±0.1	NUM
admet-491	53	49	cm	cm	NOUN
admet-491	53	50	of	of	ADP
admet-491	53	51	total	total	ADJ
admet-491	53	52	/	/	SYM
admet-491	53	53	effective	effective	ADJ
admet-491	53	54	lengths	length	NOUN
admet-491	53	55	(	(	PUNCT
admet-491	53	56	polymicro	polymicro	NOUN
admet-491	53	57	technologies	technology	NOUN
admet-491	53	58	,	,	PUNCT
admet-491	53	59	phoenix	phoenix	PROPN
admet-491	53	60	,	,	PUNCT
admet-491	53	61	usa	usa	PROPN
admet-491	53	62	)	)	PUNCT
admet-491	53	63	were	be	AUX
admet-491	53	64	used	use	VERB
admet-491	53	65	.	.	PUNCT
admet-491	54	1	the	the	DET
admet-491	54	2	cassette	cassette	NOUN
admet-491	54	3	temperature	temperature	NOUN
admet-491	54	4	was	be	AUX
admet-491	54	5	set	set	VERB
admet-491	54	6	to	to	ADP
admet-491	54	7	25	25	NUM
admet-491	54	8	°	°	NOUN
admet-491	54	9	c	c	NOUN
admet-491	54	10	(	(	PUNCT
admet-491	54	11	forced	force	VERB
admet-491	54	12	air	air	NOUN
admet-491	54	13	)	)	PUNCT
admet-491	54	14	and	and	CCONJ
admet-491	54	15	samples	sample	NOUN
admet-491	54	16	were	be	AUX
admet-491	54	17	injected	inject	VERB
admet-491	54	18	hydrodynamically	hydrodynamically	ADV
admet-491	54	19	by	by	ADP
admet-491	54	20	application	application	NOUN
admet-491	54	21	of	of	ADP
admet-491	54	22	a	a	DET
admet-491	54	23	pressure	pressure	NOUN
admet-491	54	24	of	of	ADP
admet-491	54	25	50	50	NUM
admet-491	54	26	mbar	mbar	NOUN
admet-491	54	27	for	for	ADP
admet-491	54	28	10	10	NUM
admet-491	54	29	s.	s.	PROPN
admet-491	54	30	separations	separation	NOUN
admet-491	54	31	were	be	AUX
admet-491	54	32	carried	carry	VERB
admet-491	54	33	by	by	ADP
admet-491	54	34	out	out	ADP
admet-491	54	35	applying	apply	VERB
admet-491	54	36	a	a	DET
admet-491	54	37	voltage	voltage	NOUN
admet-491	54	38	of	of	ADP
admet-491	54	39	-24	-24	X
admet-491	54	40	kv	kv	PROPN
admet-491	54	41	(	(	PUNCT
admet-491	54	42	inlet	inlet	NOUN
admet-491	54	43	,	,	PUNCT
admet-491	54	44	cathode	cathode	NOUN
admet-491	54	45	;	;	PUNCT
admet-491	54	46	outlet	outlet	NOUN
admet-491	54	47	,	,	PUNCT
admet-491	54	48	anode	anode	NOUN
admet-491	54	49	)	)	PUNCT
admet-491	54	50	and	and	CCONJ
admet-491	54	51	an	an	DET
admet-491	54	52	external	external	ADJ
admet-491	54	53	pressure	pressure	NOUN
admet-491	54	54	of	of	ADP
admet-491	54	55	50	50	NUM
admet-491	54	56	mbar	mbar	NOUN
admet-491	54	57	(	(	PUNCT
admet-491	54	58	on	on	ADP
admet-491	54	59	the	the	DET
admet-491	54	60	inlet	inlet	NOUN
admet-491	54	61	vial	vial	ADJ
admet-491	54	62	)	)	PUNCT
admet-491	54	63	.	.	PUNCT
admet-491	55	1	current	current	ADJ
admet-491	55	2	intensities	intensity	NOUN
admet-491	55	3	were	be	AUX
admet-491	55	4	typically	typically	ADV
admet-491	55	5	in	in	ADP
admet-491	55	6	the	the	DET
admet-491	55	7	range	range	NOUN
admet-491	55	8	between	between	ADP
admet-491	55	9	30	30	NUM
admet-491	55	10	and	and	CCONJ
admet-491	55	11	40	40	NUM
admet-491	55	12	µa	µa	NOUN
admet-491	55	13	.	.	PUNCT
admet-491	56	1	capillary	capillary	ADJ
admet-491	56	2	preconditioning	preconditioning	NOUN
admet-491	56	3	was	be	AUX
admet-491	56	4	performed	perform	VERB
admet-491	56	5	by	by	ADP
admet-491	56	6	me	i	PRON
admet-491	56	7	for	for	ADP
admet-491	56	8	2	2	NUM
admet-491	56	9	min	min	NOUN
admet-491	56	10	and	and	CCONJ
admet-491	56	11	postconditioning	postconditione	VERB
admet-491	56	12	by	by	ADP
admet-491	56	13	1	1	NUM
admet-491	56	14	m	m	NOUN
admet-491	56	15	sodium	sodium	NOUN
admet-491	56	16	hydroxide	hydroxide	NOUN
admet-491	56	17	and	and	CCONJ
admet-491	56	18	water	water	NOUN
admet-491	56	19	for	for	ADP
admet-491	56	20	2	2	NUM
admet-491	56	21	min	min	NOUN
admet-491	56	22	each	each	PRON
admet-491	56	23	.	.	PUNCT
admet-491	57	1	ph	ph	PROPN
admet-491	57	2	was	be	AUX
admet-491	57	3	measured	measure	VERB
admet-491	57	4	with	with	ADP
admet-491	57	5	a	a	DET
admet-491	57	6	crison	crison	NOUN
admet-491	57	7	glp	glp	PROPN
admet-491	57	8	22	22	NUM
admet-491	57	9	ph	ph	NOUN
admet-491	57	10	meter	meter	NOUN
admet-491	57	11	(	(	PUNCT
admet-491	57	12	barcelona	barcelona	PROPN
admet-491	57	13	,	,	PUNCT
admet-491	57	14	spain	spain	PROPN
admet-491	57	15	)	)	PUNCT
admet-491	57	16	using	use	VERB
admet-491	57	17	a	a	DET
admet-491	57	18	5014	5014	NUM
admet-491	57	19	combination	combination	NOUN
admet-491	57	20	glass	glass	NOUN
admet-491	57	21	electrode	electrode	NOUN
admet-491	57	22	and	and	CCONJ
admet-491	57	23	a	a	DET
admet-491	57	24	reference	reference	NOUN
admet-491	57	25	electrode	electrode	NOUN
admet-491	57	26	with	with	ADP
admet-491	57	27	a	a	DET
admet-491	57	28	3.0	3.0	NUM
admet-491	57	29	mol	mol	ADP
admet-491	57	30	l−1	l−1	PROPN
admet-491	57	31	kcl	kcl	ADJ
admet-491	57	32	solution	solution	NOUN
admet-491	57	33	in	in	ADP
admet-491	57	34	water	water	NOUN
admet-491	57	35	salt	salt	NOUN
admet-491	57	36	bridge	bridge	PROPN
admet-491	57	37	.	.	PUNCT
admet-491	58	1	mes	me	NOUN
admet-491	58	2	were	be	AUX
admet-491	58	3	sonicated	sonicate	VERB
admet-491	58	4	in	in	ADP
admet-491	58	5	a	a	DET
admet-491	58	6	j.p	j.p	PROPN
admet-491	58	7	.	.	PROPN
admet-491	58	8	selecta	selecta	PROPN
admet-491	58	9	(	(	PUNCT
admet-491	58	10	barcelona	barcelona	PROPN
admet-491	58	11	,	,	PUNCT
admet-491	58	12	spain	spain	PROPN
admet-491	58	13	)	)	PUNCT
admet-491	58	14	ultrasonic	ultrasonic	ADJ
admet-491	58	15	bath	bath	NOUN
admet-491	58	16	at	at	ADP
admet-491	58	17	a	a	DET
admet-491	58	18	power	power	NOUN
admet-491	58	19	of	of	ADP
admet-491	58	20	360	360	NUM
admet-491	58	21	w.	w.	NOUN
admet-491	58	22	reagents	reagent	NOUN
admet-491	58	23	water	water	NOUN
admet-491	58	24	was	be	AUX
admet-491	58	25	deionized	deionize	VERB
admet-491	58	26	to	to	ADP
admet-491	58	27	a	a	DET
admet-491	58	28	resistivity	resistivity	NOUN
admet-491	58	29	of	of	ADP
admet-491	58	30	18.2	18.2	NUM
admet-491	58	31	mω	mω	NOUN
admet-491	58	32	cm	cm	NOUN
admet-491	58	33	by	by	ADP
admet-491	58	34	a	a	DET
admet-491	58	35	milli	milli	ADJ
admet-491	58	36	-	-	ADJ
admet-491	58	37	q	q	ADJ
admet-491	58	38	®	®	NOUN
admet-491	58	39	plus	plus	CCONJ
admet-491	58	40	system	system	NOUN
admet-491	58	41	(	(	PUNCT
admet-491	58	42	millipore	millipore	PROPN
admet-491	58	43	,	,	PUNCT
admet-491	58	44	billerica	billerica	PROPN
admet-491	58	45	,	,	PUNCT
admet-491	58	46	ma	ma	PROPN
admet-491	58	47	,	,	PUNCT
admet-491	58	48	usa	usa	PROPN
admet-491	58	49	)	)	PUNCT
admet-491	58	50	,	,	PUNCT
admet-491	58	51	and	and	CCONJ
admet-491	58	52	buffers	buffer	NOUN
admet-491	58	53	were	be	AUX
admet-491	58	54	prepared	prepare	VERB
admet-491	58	55	for	for	ADP
admet-491	58	56	analysis	analysis	NOUN
admet-491	58	57	from	from	ADP
admet-491	58	58	phosphoric	phosphoric	NOUN
admet-491	58	59	acid	acid	NOUN
admet-491	58	60	(	(	PUNCT
admet-491	58	61	merck	merck	PROPN
admet-491	58	62	,	,	PUNCT
admet-491	58	63	85	85	NUM
admet-491	58	64	%	%	NOUN
admet-491	58	65	)	)	PUNCT
admet-491	58	66	,	,	PUNCT
admet-491	58	67	and	and	CCONJ
admet-491	58	68	sodium	sodium	NOUN
admet-491	58	69	hydroxide	hydroxide	NOUN
admet-491	58	70	(	(	PUNCT
admet-491	58	71	sigma	sigma	PROPN
admet-491	58	72	-	-	PUNCT
admet-491	58	73	aldrich	aldrich	NOUN
admet-491	58	74	,	,	PUNCT
admet-491	58	75	pellets	pellet	NOUN
admet-491	58	76	,	,	PUNCT
admet-491	58	77	>	>	PUNCT
admet-491	58	78	98	98	NUM
admet-491	58	79	%	%	NOUN
admet-491	58	80	)	)	PUNCT
admet-491	58	81	.	.	PUNCT
admet-491	59	1	me	i	PRON
admet-491	59	2	consisted	consist	VERB
admet-491	59	3	of	of	ADP
admet-491	59	4	sds	sds	PROPN
admet-491	59	5	(	(	PUNCT
admet-491	59	6	≥99.0	≥99.0	PUNCT
admet-491	59	7	%	%	NOUN
admet-491	59	8	)	)	PUNCT
admet-491	59	9	,	,	PUNCT
admet-491	59	10	1	1	NUM
admet-491	59	11	-	-	PUNCT
admet-491	59	12	butanol	butanol	NOUN
admet-491	59	13	(	(	PUNCT
admet-491	59	14	hplc	hplc	NOUN
admet-491	59	15	grade	grade	NOUN
admet-491	59	16	)	)	PUNCT
admet-491	59	17	,	,	PUNCT
admet-491	59	18	and	and	CCONJ
admet-491	59	19	heptane	heptane	NOUN
admet-491	59	20	(	(	PUNCT
admet-491	59	21	hplc	hplc	NOUN
admet-491	59	22	grade	grade	NOUN
admet-491	59	23	)	)	PUNCT
admet-491	59	24	,	,	PUNCT
admet-491	59	25	all	all	ADV
admet-491	59	26	from	from	ADP
admet-491	59	27	sigma	sigma	PROPN
admet-491	59	28	-	-	PUNCT
admet-491	59	29	aldrich	aldrich	NOUN
admet-491	59	30	.	.	PUNCT
admet-491	60	1	injected	inject	VERB
admet-491	60	2	compounds	compound	NOUN
admet-491	60	3	were	be	AUX
admet-491	60	4	purchased	purchase	VERB
admet-491	60	5	(	(	PUNCT
admet-491	60	6	table	table	NOUN
admet-491	60	7	1	1	NUM
admet-491	60	8	)	)	PUNCT
admet-491	60	9	from	from	ADP
admet-491	60	10	j.t	j.t	PROPN
admet-491	60	11	.	.	PROPN
admet-491	60	12	baker	baker	PROPN
admet-491	60	13	,	,	PUNCT
admet-491	60	14	carlo	carlo	PROPN
admet-491	60	15	erba	erba	PROPN
admet-491	60	16	,	,	PUNCT
admet-491	60	17	fluka	fluka	NOUN
admet-491	60	18	,	,	PUNCT
admet-491	60	19	merck	merck	PROPN
admet-491	60	20	,	,	PUNCT
admet-491	60	21	sigma	sigma	PROPN
admet-491	60	22	-	-	PUNCT
admet-491	60	23	aldrich	aldrich	NOUN
admet-491	60	24	,	,	PUNCT
admet-491	60	25	and	and	CCONJ
admet-491	60	26	schuhardt	schuhardt	NOUN
admet-491	60	27	;	;	PUNCT
admet-491	60	28	all	all	PRON
admet-491	60	29	of	of	ADP
admet-491	60	30	high	high	ADJ
admet-491	60	31	purity	purity	NOUN
admet-491	60	32	grade	grade	NOUN
admet-491	60	33	.	.	PUNCT
admet-491	61	1	the	the	DET
admet-491	61	2	neutral	neutral	ADJ
admet-491	61	3	and	and	CCONJ
admet-491	61	4	me	i	PRON
admet-491	61	5	markers	marker	NOUN
admet-491	61	6	were	be	AUX
admet-491	61	7	dmso	dmso	NOUN
admet-491	61	8	(	(	PUNCT
admet-491	61	9	merck	merck	PROPN
admet-491	61	10	,	,	PUNCT
admet-491	61	11	for	for	ADP
admet-491	61	12	analysis	analysis	NOUN
admet-491	61	13	)	)	PUNCT
admet-491	61	14	and	and	CCONJ
admet-491	61	15	dodecanophenone	dodecanophenone	NOUN
admet-491	61	16	(	(	PUNCT
admet-491	61	17	sigma	sigma	PROPN
admet-491	61	18	-	-	PUNCT
admet-491	61	19	aldrich	aldrich	NOUN
admet-491	61	20	,	,	PUNCT
admet-491	61	21	98	98	NUM
admet-491	61	22	%	%	NOUN
admet-491	61	23	)	)	PUNCT
admet-491	61	24	,	,	PUNCT
admet-491	61	25	respectively	respectively	ADV
admet-491	61	26	.	.	PUNCT
admet-491	62	1	microemulsion	microemulsion	NOUN
admet-491	62	2	and	and	CCONJ
admet-491	62	3	sample	sample	NOUN
admet-491	62	4	preparation	preparation	NOUN
admet-491	62	5	20	20	NUM
admet-491	62	6	mm	mm	NOUN
admet-491	62	7	aqueous	aqueous	ADJ
admet-491	62	8	buffers	buffer	NOUN
admet-491	62	9	were	be	AUX
admet-491	62	10	prepared	prepare	VERB
admet-491	62	11	from	from	ADP
admet-491	62	12	phosphoric	phosphoric	ADJ
admet-491	62	13	acid	acid	NOUN
admet-491	62	14	by	by	ADP
admet-491	62	15	adjusting	adjust	VERB
admet-491	62	16	the	the	DET
admet-491	62	17	ph	ph	NOUN
admet-491	62	18	to	to	ADP
admet-491	62	19	2.0	2.0	NUM
admet-491	62	20	by	by	ADP
admet-491	62	21	the	the	DET
admet-491	62	22	addition	addition	NOUN
admet-491	62	23	of	of	ADP
admet-491	62	24	small	small	ADJ
admet-491	62	25	volumes	volume	NOUN
admet-491	62	26	of	of	ADP
admet-491	62	27	a	a	DET
admet-491	62	28	3	3	NUM
admet-491	62	29	m	m	NOUN
admet-491	62	30	sodium	sodium	NOUN
admet-491	62	31	hydroxide	hydroxide	NOUN
admet-491	62	32	solution	solution	NOUN
admet-491	62	33	prepared	prepare	VERB
admet-491	62	34	shortly	shortly	ADV
admet-491	62	35	before	before	ADP
admet-491	62	36	use	use	NOUN
admet-491	62	37	.	.	PUNCT
admet-491	63	1	1.3	1.3	NUM
admet-491	63	2	%	%	NOUN
admet-491	63	3	w	w	PROPN
admet-491	63	4	/	/	SYM
admet-491	63	5	v	v	NOUN
admet-491	63	6	of	of	ADP
admet-491	63	7	sds	sds	PROPN
admet-491	63	8	was	be	AUX
admet-491	63	9	dissolved	dissolve	VERB
admet-491	63	10	in	in	ADP
admet-491	63	11	the	the	DET
admet-491	63	12	aqueous	aqueous	ADJ
admet-491	63	13	buffer	buffer	NOUN
admet-491	63	14	at	at	ADP
admet-491	63	15	room	room	NOUN
admet-491	63	16	temperature	temperature	NOUN
admet-491	63	17	and	and	CCONJ
admet-491	63	18	stirred	stir	VERB
admet-491	63	19	by	by	ADP
admet-491	63	20	magnetic	magnetic	ADJ
admet-491	63	21	stirrer	stirrer	NOUN
admet-491	63	22	until	until	SCONJ
admet-491	63	23	a	a	DET
admet-491	63	24	transparent	transparent	ADJ
admet-491	63	25	colorless	colorless	ADJ
admet-491	63	26	solution	solution	NOUN
admet-491	63	27	was	be	AUX
admet-491	63	28	obtained	obtain	VERB
admet-491	63	29	,	,	PUNCT
admet-491	63	30	and	and	CCONJ
admet-491	63	31	the	the	DET
admet-491	63	32	ph	ph	NOUN
admet-491	63	33	then	then	ADV
admet-491	63	34	adjusted	adjust	VERB
admet-491	63	35	if	if	SCONJ
admet-491	63	36	necessary	necessary	ADJ
admet-491	63	37	.	.	PUNCT
admet-491	64	1	afterwards	afterwards	ADV
admet-491	64	2	,	,	PUNCT
admet-491	64	3	1	1	NUM
admet-491	64	4	-	-	PUNCT
admet-491	64	5	butanol	butanol	NOUN
admet-491	64	6	(	(	PUNCT
admet-491	64	7	sigmaaldrich	sigmaaldrich	ADV
admet-491	64	8	,	,	PUNCT
admet-491	64	9	≥	≥	NOUN
admet-491	64	10	99.4	99.4	NUM
admet-491	64	11	%	%	NOUN
admet-491	64	12	)	)	PUNCT
admet-491	64	13	was	be	AUX
admet-491	64	14	added	add	VERB
admet-491	64	15	up	up	ADP
admet-491	64	16	to	to	PART
admet-491	64	17	8.15	8.15	NUM
admet-491	64	18	%	%	NOUN
admet-491	64	19	(	(	PUNCT
admet-491	64	20	v	v	NOUN
admet-491	64	21	/	/	SYM
admet-491	64	22	v	v	NOUN
admet-491	64	23	)	)	PUNCT
admet-491	64	24	,	,	PUNCT
admet-491	64	25	followed	follow	VERB
admet-491	64	26	by	by	ADP
admet-491	64	27	heptane	heptane	NOUN
admet-491	64	28	(	(	PUNCT
admet-491	64	29	sigma	sigma	PROPN
admet-491	64	30	-	-	PUNCT
admet-491	64	31	aldrich	aldrich	PROPN
admet-491	64	32	,	,	PUNCT
admet-491	64	33	≥	≥	NUM
admet-491	64	34	99	99	NUM
admet-491	64	35	%	%	NOUN
admet-491	64	36	)	)	PUNCT
admet-491	64	37	up	up	ADP
admet-491	64	38	to	to	PART
admet-491	64	39	1.15	1.15	NUM
admet-491	64	40	%	%	NOUN
admet-491	64	41	(	(	PUNCT
admet-491	64	42	v	v	NOUN
admet-491	64	43	/	/	SYM
admet-491	64	44	v	v	NOUN
admet-491	64	45	)	)	PUNCT
admet-491	64	46	.	.	PUNCT
admet-491	65	1	both	both	DET
admet-491	65	2	organic	organic	ADJ
admet-491	65	3	solvents	solvent	NOUN
admet-491	65	4	were	be	AUX
admet-491	65	5	slowly	slowly	ADV
admet-491	65	6	added	add	VERB
admet-491	65	7	with	with	ADP
admet-491	65	8	a	a	DET
admet-491	65	9	burette	burette	NOUN
admet-491	65	10	.	.	PUNCT
admet-491	66	1	at	at	ADP
admet-491	66	2	this	this	DET
admet-491	66	3	point	point	NOUN
admet-491	66	4	,	,	PUNCT
admet-491	66	5	the	the	DET
admet-491	66	6	solution	solution	NOUN
admet-491	66	7	became	become	VERB
admet-491	66	8	white	white	ADJ
admet-491	66	9	and	and	CCONJ
admet-491	66	10	turbid	turbid	ADJ
admet-491	66	11	.	.	PUNCT
admet-491	67	1	magnetic	magnetic	ADJ
admet-491	67	2	stirring	stirring	NOUN
admet-491	67	3	was	be	AUX
admet-491	67	4	maintained	maintain	VERB
admet-491	67	5	for	for	ADP
admet-491	67	6	5	5	NUM
admet-491	67	7	minutes	minute	NOUN
admet-491	67	8	and	and	CCONJ
admet-491	67	9	then	then	ADV
admet-491	67	10	the	the	DET
admet-491	67	11	me	i	PRON
admet-491	67	12	was	be	AUX
admet-491	67	13	sonicated	sonicate	VERB
admet-491	67	14	until	until	SCONJ
admet-491	67	15	it	it	PRON
admet-491	67	16	became	become	VERB
admet-491	67	17	clear	clear	ADJ
admet-491	67	18	again	again	ADV
admet-491	67	19	.	.	PUNCT
admet-491	68	1	finally	finally	ADV
admet-491	68	2	,	,	PUNCT
admet-491	68	3	the	the	DET
admet-491	68	4	solution	solution	NOUN
admet-491	68	5	was	be	AUX
admet-491	68	6	left	leave	VERB
admet-491	68	7	to	to	PART
admet-491	68	8	stand	stand	VERB
admet-491	68	9	at	at	ADP
admet-491	68	10	room	room	NOUN
admet-491	68	11	temperature	temperature	NOUN
admet-491	68	12	for	for	ADP
admet-491	68	13	at	at	ADV
admet-491	68	14	least	least	ADV
admet-491	68	15	1	1	NUM
admet-491	68	16	hour	hour	NOUN
admet-491	68	17	.	.	PUNCT
admet-491	69	1	immediately	immediately	ADV
admet-491	69	2	before	before	SCONJ
admet-491	69	3	use	use	VERB
admet-491	69	4	the	the	DET
admet-491	69	5	me	i	PRON
admet-491	69	6	was	be	AUX
admet-491	69	7	filtered	filter	VERB
admet-491	69	8	using	use	VERB
admet-491	69	9	a	a	DET
admet-491	69	10	0.45	0.45	NUM
admet-491	69	11	μm	μm	NOUN
admet-491	69	12	nylon	nylon	NOUN
admet-491	69	13	syringe	syringe	NOUN
admet-491	69	14	filter	filter	NOUN
admet-491	69	15	(	(	PUNCT
admet-491	69	16	simplepure	simplepure	NOUN
admet-491	69	17	,	,	PUNCT
admet-491	69	18	membrane	membrane	NOUN
admet-491	69	19	-	-	PUNCT
admet-491	69	20	solutions	solution	NOUN
admet-491	69	21	,	,	PUNCT
admet-491	69	22	usa	usa	PROPN
admet-491	69	23	)	)	PUNCT
admet-491	69	24	.	.	PUNCT
admet-491	70	1	sample	sample	NOUN
admet-491	70	2	solutions	solution	NOUN
admet-491	70	3	were	be	AUX
admet-491	70	4	prepared	prepare	VERB
admet-491	70	5	by	by	ADP
admet-491	70	6	dissolving	dissolve	VERB
admet-491	70	7	the	the	DET
admet-491	70	8	me	me	PROPN
admet-491	70	9	marker	marker	NOUN
admet-491	70	10	(	(	PUNCT
admet-491	70	11	dodecanophenone	dodecanophenone	NOUN
admet-491	70	12	,	,	PUNCT
admet-491	70	13	0.5	0.5	NUM
admet-491	70	14	mg	mg	NUM
admet-491	70	15	/	/	SYM
admet-491	70	16	ml	ml	NOUN
admet-491	70	17	)	)	PUNCT
admet-491	70	18	directly	directly	ADV
admet-491	70	19	into	into	ADP
admet-491	70	20	the	the	DET
admet-491	70	21	me	i	PRON
admet-491	70	22	by	by	ADP
admet-491	70	23	sonication	sonication	NOUN
admet-491	70	24	,	,	PUNCT
admet-491	70	25	followed	follow	VERB
admet-491	70	26	by	by	ADP
admet-491	70	27	the	the	DET
admet-491	70	28	addition	addition	NOUN
admet-491	70	29	of	of	ADP
admet-491	70	30	the	the	DET
admet-491	70	31	eof	eof	NOUN
admet-491	70	32	marker	marker	NOUN
admet-491	70	33	(	(	PUNCT
admet-491	70	34	dmso	dmso	NOUN
admet-491	70	35	,	,	PUNCT
admet-491	70	36	0.1	0.1	NUM
admet-491	70	37	%	%	NOUN
admet-491	70	38	in	in	ADP
admet-491	70	39	volume	volume	NOUN
admet-491	70	40	)	)	PUNCT
admet-491	70	41	and	and	CCONJ
admet-491	70	42	the	the	DET
admet-491	70	43	analytes	analyte	NOUN
admet-491	70	44	(	(	PUNCT
admet-491	70	45	0.5	0.5	NUM
admet-491	70	46	mg	mg	NOUN
admet-491	70	47	/	/	SYM
admet-491	70	48	ml	ml	NOUN
admet-491	70	49	from	from	ADP
admet-491	70	50	a	a	DET
admet-491	70	51	stock	stock	NOUN
admet-491	70	52	solution	solution	NOUN
admet-491	70	53	of	of	ADP
admet-491	70	54	10	10	NUM
admet-491	70	55	mg	mg	NUM
admet-491	70	56	/	/	SYM
admet-491	70	57	ml	ml	NOUN
admet-491	70	58	in	in	ADP
admet-491	70	59	methanol	methanol	NOUN
admet-491	70	60	)	)	PUNCT
admet-491	70	61	.	.	PUNCT
admet-491	71	1	results	result	NOUN
admet-491	71	2	and	and	CCONJ
admet-491	71	3	discussion	discussion	NOUN
admet-491	71	4	method	method	NOUN
admet-491	71	5	development	development	NOUN
admet-491	71	6	:	:	PUNCT
admet-491	71	7	pressure	pressure	NOUN
admet-491	71	8	-	-	PUNCT
admet-491	71	9	assisted	assist	VERB
admet-491	71	10	meekc	meekc	NOUN
admet-491	71	11	with	with	ADP
admet-491	71	12	reversed	reverse	VERB
admet-491	71	13	polarity	polarity	NOUN
admet-491	71	14	using	use	VERB
admet-491	71	15	uncoated	uncoated	ADJ
admet-491	71	16	fused	fuse	VERB
admet-491	71	17	silica	silica	NOUN
admet-491	71	18	capillaries	capillary	NOUN
admet-491	71	19	firstly	firstly	ADV
admet-491	71	20	,	,	PUNCT
admet-491	71	21	it	it	PRON
admet-491	71	22	was	be	AUX
admet-491	71	23	necessary	necessary	ADJ
admet-491	71	24	to	to	PART
admet-491	71	25	establish	establish	VERB
admet-491	71	26	the	the	DET
admet-491	71	27	experimental	experimental	ADJ
admet-491	71	28	conditions	condition	NOUN
admet-491	71	29	(	(	PUNCT
admet-491	71	30	ph	ph	PROPN
admet-491	71	31	,	,	PUNCT
admet-491	71	32	sds	sds	PROPN
admet-491	71	33	content	content	NOUN
admet-491	71	34	,	,	PUNCT
admet-491	71	35	capillary	capillary	ADJ
admet-491	71	36	length	length	NOUN
admet-491	71	37	,	,	PUNCT
admet-491	71	38	applied	apply	VERB
admet-491	71	39	voltage	voltage	NOUN
admet-491	71	40	and	and	CCONJ
admet-491	71	41	pressure	pressure	NOUN
admet-491	71	42	)	)	PUNCT
admet-491	71	43	to	to	PART
admet-491	71	44	allow	allow	VERB
admet-491	71	45	the	the	DET
admet-491	71	46	determination	determination	NOUN
admet-491	71	47	of	of	ADP
admet-491	71	48	a	a	DET
admet-491	71	49	wide	wide	ADJ
admet-491	71	50	range	range	NOUN
admet-491	71	51	of	of	ADP
admet-491	71	52	lipophilicity	lipophilicity	NOUN
admet-491	71	53	values	value	NOUN
admet-491	71	54	in	in	ADP
admet-491	71	55	relatively	relatively	ADV
admet-491	71	56	short	short	ADJ
admet-491	71	57	analysis	analysis	NOUN
admet-491	71	58	times	time	NOUN
admet-491	71	59	.	.	PUNCT
admet-491	72	1	thus	thus	ADV
admet-491	72	2	,	,	PUNCT
admet-491	72	3	mixtures	mixture	NOUN
admet-491	72	4	of	of	ADP
admet-491	72	5	substances	substance	NOUN
admet-491	72	6	with	with	ADP
admet-491	72	7	known	know	VERB
admet-491	72	8	log	log	NOUN
admet-491	72	9	po	po	NOUN
admet-491	72	10	/	/	SYM
admet-491	72	11	w	w	NOUN
admet-491	72	12	values	value	NOUN
admet-491	72	13	were	be	AUX
admet-491	72	14	injected	inject	VERB
admet-491	72	15	in	in	ADP
admet-491	72	16	order	order	NOUN
admet-491	72	17	to	to	PART
admet-491	72	18	test	test	VERB
admet-491	72	19	the	the	DET
admet-491	72	20	system	system	NOUN
admet-491	72	21	behavior	behavior	NOUN
admet-491	72	22	.	.	PUNCT
admet-491	73	1	these	these	DET
admet-491	73	2	compounds	compound	NOUN
admet-491	73	3	were	be	AUX
admet-491	73	4	n	n	PRON
admet-491	73	5	,	,	PUNCT
admet-491	73	6	n	n	CCONJ
admet-491	73	7	-	-	PUNCT
admet-491	73	8	dimethylacetamide	dimethylacetamide	ADJ
admet-491	73	9	,	,	PUNCT
admet-491	73	10	1	1	NUM
admet-491	73	11	-	-	PUNCT
admet-491	73	12	phenylthiourea	phenylthiourea	NOUN
admet-491	73	13	,	,	PUNCT
admet-491	73	14	acetophenone	acetophenone	NOUN
admet-491	73	15	,	,	PUNCT
admet-491	73	16	butyrophenone	butyrophenone	NOUN
admet-491	73	17	,	,	PUNCT
admet-491	73	18	propylbenzene	propylbenzene	NOUN
admet-491	73	19	,	,	PUNCT
admet-491	73	20	and	and	CCONJ
admet-491	73	21	pentachloronitrobenzene	pentachloronitrobenzene	NOUN
admet-491	73	22	,	,	PUNCT
admet-491	73	23	and	and	CCONJ
admet-491	73	24	their	their	PRON
admet-491	73	25	corresponding	corresponding	ADJ
admet-491	73	26	measured	measure	VERB
admet-491	73	27	log	log	NOUN
admet-491	73	28	po	po	NOUN
admet-491	73	29	/	/	SYM
admet-491	73	30	w	w	PROPN
admet-491	73	31	admet	admet	PROPN
admet-491	73	32	&	&	CCONJ
admet-491	73	33	dmpk	dmpk	PROPN
admet-491	73	34	6(2	6(2	NUM
admet-491	73	35	)	)	PUNCT
admet-491	73	36	(	(	PUNCT
admet-491	73	37	2018	2018	NUM
admet-491	73	38	)	)	PUNCT
admet-491	73	39	153	153	NUM
admet-491	73	40	-	-	SYM
admet-491	73	41	161	161	NUM
admet-491	73	42	lipophylicity	lipophylicity	NOUN
admet-491	73	43	determination	determination	NOUN
admet-491	73	44	of	of	ADP
admet-491	73	45	acidic	acidic	ADJ
admet-491	73	46	compounds	compound	NOUN
admet-491	73	47	by	by	ADP
admet-491	73	48	meekc	meekc	ADJ
admet-491	73	49	doi	doi	PROPN
admet-491	73	50	:	:	PUNCT
admet-491	73	51	10.5599	10.5599	NUM
admet-491	73	52	/	/	SYM
admet-491	73	53	admet.491	admet.491	PROPN
admet-491	73	54	157	157	NUM
admet-491	73	55	values	value	NOUN
admet-491	73	56	are	be	AUX
admet-491	73	57	-0.77	-0.77	ADJ
admet-491	73	58	,	,	PUNCT
admet-491	73	59	0.73	0.73	NUM
admet-491	73	60	,	,	PUNCT
admet-491	73	61	1.58	1.58	NUM
admet-491	73	62	,	,	PUNCT
admet-491	73	63	2.66	2.66	NUM
admet-491	73	64	,	,	PUNCT
admet-491	73	65	3.72	3.72	NUM
admet-491	73	66	,	,	PUNCT
admet-491	73	67	and	and	CCONJ
admet-491	73	68	5.10	5.10	NUM
admet-491	73	69	,	,	PUNCT
admet-491	73	70	respectively	respectively	ADV
admet-491	73	71	[	[	X
admet-491	73	72	21	21	NUM
admet-491	73	73	]	]	PUNCT
admet-491	73	74	.	.	PUNCT
admet-491	74	1	these	these	DET
admet-491	74	2	compounds	compound	NOUN
admet-491	74	3	were	be	AUX
admet-491	74	4	easily	easily	ADV
admet-491	74	5	detected	detect	VERB
admet-491	74	6	by	by	ADP
admet-491	74	7	uv	uv	NOUN
admet-491	74	8	and	and	CCONJ
admet-491	74	9	they	they	PRON
admet-491	74	10	behave	behave	VERB
admet-491	74	11	as	as	ADP
admet-491	74	12	neutral	neutral	ADJ
admet-491	74	13	species	specie	NOUN
admet-491	74	14	nearly	nearly	ADV
admet-491	74	15	over	over	ADP
admet-491	74	16	all	all	PRON
admet-491	74	17	of	of	ADP
admet-491	74	18	the	the	DET
admet-491	74	19	ph	ph	ADJ
admet-491	74	20	range	range	NOUN
admet-491	74	21	.	.	PUNCT
admet-491	75	1	only	only	ADV
admet-491	75	2	1	1	NUM
admet-491	75	3	-	-	PUNCT
admet-491	75	4	phenylthiourea	phenylthiourea	NOUN
admet-491	75	5	could	could	AUX
admet-491	75	6	behave	behave	VERB
admet-491	75	7	as	as	ADP
admet-491	75	8	an	an	DET
admet-491	75	9	ampholyte	ampholyte	NOUN
admet-491	75	10	,	,	PUNCT
admet-491	75	11	but	but	CCONJ
admet-491	75	12	basic	basic	ADJ
admet-491	75	13	and	and	CCONJ
admet-491	75	14	acidic	acidic	ADJ
admet-491	75	15	groups	group	NOUN
admet-491	75	16	were	be	AUX
admet-491	75	17	expected	expect	VERB
admet-491	75	18	to	to	PART
admet-491	75	19	be	be	AUX
admet-491	75	20	too	too	ADV
admet-491	75	21	extreme	extreme	ADJ
admet-491	75	22	to	to	PART
admet-491	75	23	cause	cause	VERB
admet-491	75	24	a	a	DET
admet-491	75	25	significant	significant	ADJ
admet-491	75	26	ionization	ionization	NOUN
admet-491	75	27	at	at	ADP
admet-491	75	28	ph	ph	PROPN
admet-491	75	29	2.0	2.0	NUM
admet-491	75	30	(	(	PUNCT
admet-491	75	31	their	their	PRON
admet-491	75	32	calculated	calculate	VERB
admet-491	75	33	pka	pka	PROPN
admet-491	75	34	values	value	NOUN
admet-491	75	35	are	be	AUX
admet-491	75	36	0.7	0.7	NUM
admet-491	75	37	and	and	CCONJ
admet-491	75	38	13.1	13.1	NUM
admet-491	75	39	,	,	PUNCT
admet-491	75	40	respectively	respectively	ADV
admet-491	75	41	[	[	X
admet-491	75	42	22	22	NUM
admet-491	75	43	]	]	PUNCT
admet-491	75	44	)	)	PUNCT
admet-491	75	45	.	.	PUNCT
admet-491	76	1	under	under	ADP
admet-491	76	2	the	the	DET
admet-491	76	3	conditions	condition	NOUN
admet-491	76	4	of	of	ADP
admet-491	76	5	assay	assay	NOUN
admet-491	76	6	in	in	ADP
admet-491	76	7	the	the	DET
admet-491	76	8	present	present	ADJ
admet-491	76	9	work	work	NOUN
admet-491	76	10	,	,	PUNCT
admet-491	76	11	pentachloronitrobenze	pentachloronitrobenze	PROPN
admet-491	76	12	was	be	AUX
admet-491	76	13	too	too	ADV
admet-491	76	14	lipophilic	lipophilic	ADJ
admet-491	76	15	to	to	PART
admet-491	76	16	be	be	AUX
admet-491	76	17	sufficiently	sufficiently	ADV
admet-491	76	18	resolved	resolve	VERB
admet-491	76	19	from	from	ADP
admet-491	76	20	the	the	DET
admet-491	76	21	me	me	PROPN
admet-491	76	22	marker	marker	NOUN
admet-491	76	23	(	(	PUNCT
admet-491	76	24	dodecanophenone	dodecanophenone	NOUN
admet-491	76	25	)	)	PUNCT
admet-491	76	26	.	.	PUNCT
admet-491	77	1	it	it	PRON
admet-491	77	2	must	must	AUX
admet-491	77	3	be	be	AUX
admet-491	77	4	pointed	point	VERB
admet-491	77	5	out	out	ADP
admet-491	77	6	that	that	SCONJ
admet-491	77	7	at	at	ADP
admet-491	77	8	very	very	ADV
admet-491	77	9	acidic	acidic	ADJ
admet-491	77	10	conditions	condition	NOUN
admet-491	77	11	the	the	DET
admet-491	77	12	direction	direction	NOUN
admet-491	77	13	of	of	ADP
admet-491	77	14	the	the	DET
admet-491	77	15	eof	eof	NOUN
admet-491	77	16	is	be	AUX
admet-491	77	17	found	find	VERB
admet-491	77	18	to	to	PART
admet-491	77	19	be	be	AUX
admet-491	77	20	reversed	reverse	VERB
admet-491	77	21	in	in	ADP
admet-491	77	22	relation	relation	NOUN
admet-491	77	23	to	to	ADP
admet-491	77	24	neutral	neutral	ADJ
admet-491	77	25	and	and	CCONJ
admet-491	77	26	alkaline	alkaline	NOUN
admet-491	77	27	running	running	NOUN
admet-491	77	28	buffers	buffer	NOUN
admet-491	77	29	.	.	PUNCT
admet-491	78	1	therefore	therefore	ADV
admet-491	78	2	,	,	PUNCT
admet-491	78	3	in	in	ADP
admet-491	78	4	order	order	NOUN
admet-491	78	5	to	to	PART
admet-491	78	6	overcome	overcome	VERB
admet-491	78	7	this	this	DET
admet-491	78	8	eof	eof	NOUN
admet-491	78	9	issue	issue	NOUN
admet-491	78	10	the	the	DET
admet-491	78	11	instrument	instrument	NOUN
admet-491	78	12	polarity	polarity	NOUN
admet-491	78	13	was	be	AUX
admet-491	78	14	reversed	reverse	VERB
admet-491	78	15	,	,	PUNCT
admet-491	78	16	with	with	ADP
admet-491	78	17	the	the	DET
admet-491	78	18	anode	anode	NOUN
admet-491	78	19	in	in	ADP
admet-491	78	20	the	the	DET
admet-491	78	21	destination	destination	NOUN
admet-491	78	22	vial	vial	ADJ
admet-491	78	23	(	(	PUNCT
admet-491	78	24	outlet	outlet	NOUN
admet-491	78	25	)	)	PUNCT
admet-491	78	26	and	and	CCONJ
admet-491	78	27	the	the	DET
admet-491	78	28	cathode	cathode	NOUN
admet-491	78	29	in	in	ADP
admet-491	78	30	source	source	NOUN
admet-491	78	31	vial	vial	ADJ
admet-491	78	32	(	(	PUNCT
admet-491	78	33	inlet	inlet	NOUN
admet-491	78	34	)	)	PUNCT
admet-491	78	35	.	.	PUNCT
admet-491	79	1	thus	thus	ADV
admet-491	79	2	,	,	PUNCT
admet-491	79	3	the	the	DET
admet-491	79	4	negatively	negatively	ADV
admet-491	79	5	charged	charge	VERB
admet-491	79	6	me	i	PRON
admet-491	79	7	droplets	droplet	NOUN
admet-491	79	8	(	(	PUNCT
admet-491	79	9	because	because	SCONJ
admet-491	79	10	of	of	ADP
admet-491	79	11	the	the	DET
admet-491	79	12	sds	sds	NOUN
admet-491	79	13	)	)	PUNCT
admet-491	79	14	were	be	AUX
admet-491	79	15	the	the	DET
admet-491	79	16	first	first	ADJ
admet-491	79	17	to	to	PART
admet-491	79	18	reach	reach	VERB
admet-491	79	19	the	the	DET
admet-491	79	20	detector	detector	NOUN
admet-491	79	21	window	window	NOUN
admet-491	79	22	,	,	PUNCT
admet-491	79	23	while	while	SCONJ
admet-491	79	24	the	the	DET
admet-491	79	25	eof	eof	NOUN
admet-491	79	26	marker	marker	NOUN
admet-491	79	27	migrated	migrate	VERB
admet-491	79	28	last	last	ADV
admet-491	79	29	.	.	PUNCT
admet-491	80	1	the	the	DET
admet-491	80	2	application	application	NOUN
admet-491	80	3	of	of	ADP
admet-491	80	4	an	an	DET
admet-491	80	5	external	external	ADJ
admet-491	80	6	pressure	pressure	NOUN
admet-491	80	7	,	,	PUNCT
admet-491	80	8	which	which	PRON
admet-491	80	9	pushes	push	VERB
admet-491	80	10	the	the	DET
admet-491	80	11	me	i	PRON
admet-491	80	12	filling	fill	VERB
admet-491	80	13	the	the	DET
admet-491	80	14	capillary	capillary	NOUN
admet-491	80	15	towards	towards	ADP
admet-491	80	16	the	the	DET
admet-491	80	17	detector	detector	NOUN
admet-491	80	18	,	,	PUNCT
admet-491	80	19	is	be	AUX
admet-491	80	20	fundamental	fundamental	ADJ
admet-491	80	21	to	to	ADP
admet-491	80	22	achieving	achieve	VERB
admet-491	80	23	a	a	DET
admet-491	80	24	good	good	ADJ
admet-491	80	25	separation	separation	NOUN
admet-491	80	26	of	of	ADP
admet-491	80	27	the	the	DET
admet-491	80	28	standard	standard	ADJ
admet-491	80	29	mixture	mixture	NOUN
admet-491	80	30	in	in	ADP
admet-491	80	31	relatively	relatively	ADV
admet-491	80	32	short	short	ADJ
admet-491	80	33	analysis	analysis	NOUN
admet-491	80	34	times	time	NOUN
admet-491	80	35	.	.	PUNCT
admet-491	80	36	table	table	NOUN
admet-491	80	37	1	1	NUM
admet-491	80	38	.	.	PUNCT
admet-491	80	39	experimental	experimental	PROPN
admet-491	80	40	log	log	PROPN
admet-491	80	41	po	po	PROPN
admet-491	80	42	/	/	SYM
admet-491	80	43	w	w	PROPN
admet-491	80	44	from	from	ADP
admet-491	80	45	the	the	DET
admet-491	80	46	literature	literature	NOUN
admet-491	80	47	[	[	X
admet-491	80	48	21	21	NUM
admet-491	80	49	]	]	PUNCT
admet-491	80	50	and	and	CCONJ
admet-491	80	51	the	the	DET
admet-491	80	52	calculated	calculated	ADJ
admet-491	80	53	pka	pka	PROPN
admet-491	80	54	values	value	NOUN
admet-491	80	55	(	(	PUNCT
admet-491	80	56	galas	gala	NOUN
admet-491	80	57	[	[	X
admet-491	80	58	22	22	NUM
admet-491	80	59	]	]	PUNCT
admet-491	80	60	)	)	PUNCT
admet-491	80	61	of	of	ADP
admet-491	80	62	the	the	DET
admet-491	80	63	acidic	acidic	ADJ
admet-491	80	64	compounds	compound	NOUN
admet-491	80	65	included	include	VERB
admet-491	80	66	in	in	ADP
admet-491	80	67	the	the	DET
admet-491	80	68	study	study	NOUN
admet-491	80	69	,	,	PUNCT
admet-491	80	70	together	together	ADV
admet-491	80	71	with	with	ADP
admet-491	80	72	the	the	DET
admet-491	80	73	estimated	estimate	VERB
admet-491	80	74	molar	molar	ADJ
admet-491	80	75	percentage	percentage	NOUN
admet-491	80	76	of	of	ADP
admet-491	80	77	the	the	DET
admet-491	80	78	neutral	neutral	ADJ
admet-491	80	79	species	specie	NOUN
admet-491	80	80	at	at	ADP
admet-491	80	81	ph	ph	PROPN
admet-491	80	82	2.0	2.0	NUM
admet-491	80	83	.	.	PUNCT
admet-491	81	1	compound	compound	PROPN
admet-491	81	2	log	log	PROPN
admet-491	81	3	po	po	PROPN
admet-491	81	4	/	/	SYM
admet-491	81	5	w	w	PROPN
admet-491	81	6	pka	pka	NOUN
admet-491	81	7	%	%	INTJ
admet-491	81	8	neutral	neutral	ADJ
admet-491	81	9	compound	compound	NOUN
admet-491	81	10	log	log	PROPN
admet-491	81	11	po	po	NOUN
admet-491	81	12	/	/	SYM
admet-491	81	13	w	w	PROPN
admet-491	81	14	pka	pka	NOUN
admet-491	81	15	%	%	INTJ
admet-491	81	16	neutral	neutral	ADJ
admet-491	81	17	piracetam	piracetam	NOUN
admet-491	81	18	-1.54	-1.54	NUM
admet-491	81	19	13.6	13.6	NUM
admet-491	81	20	100	100	NUM
admet-491	81	21	%	%	NOUN
admet-491	81	22	4	4	NUM
admet-491	81	23	-	-	PUNCT
admet-491	81	24	nitrobenzoic	nitrobenzoic	ADJ
admet-491	81	25	acid	acid	NOUN
admet-491	81	26	1.89	1.89	NUM
admet-491	81	27	3.3	3.3	NUM
admet-491	81	28	95	95	NUM
admet-491	81	29	%	%	NOUN
admet-491	81	30	barbituric	barbituric	NOUN
admet-491	81	31	acid	acid	NOUN
admet-491	81	32	-1.41	-1.41	NOUN
admet-491	81	33	4.0	4.0	NUM
admet-491	81	34	99	99	NUM
admet-491	81	35	%	%	NOUN
admet-491	81	36	4	4	NUM
admet-491	81	37	-	-	PUNCT
admet-491	81	38	nitrophenol	nitrophenol	NOUN
admet-491	81	39	1.91	1.91	NUM
admet-491	81	40	7.2	7.2	NUM
admet-491	81	41	100	100	NUM
admet-491	81	42	%	%	NOUN
admet-491	81	43	2,4	2,4	NUM
admet-491	81	44	-	-	PUNCT
admet-491	81	45	dithiouracil	dithiouracil	NOUN
admet-491	81	46	-0.86	-0.86	NUM
admet-491	81	47	6.7	6.7	NUM
admet-491	81	48	100	100	NUM
admet-491	81	49	%	%	NOUN
admet-491	81	50	furosemide	furosemide	ADV
admet-491	81	51	2.03	2.03	NUM
admet-491	81	52	3.5	3.5	NUM
admet-491	81	53	97	97	NUM
admet-491	81	54	%	%	NOUN
admet-491	81	55	hydroxypropyltheophylline	hydroxypropyltheophylline	NOUN
admet-491	81	56	-0.77	-0.77	PROPN
admet-491	81	57	13.6	13.6	NUM
admet-491	81	58	100	100	NUM
admet-491	81	59	%	%	NOUN
admet-491	81	60	pentobarbital	pentobarbital	NOUN
admet-491	81	61	2.10	2.10	NUM
admet-491	81	62	7.9	7.9	NUM
admet-491	81	63	100	100	NUM
admet-491	81	64	%	%	NOUN
admet-491	81	65	thymine	thymine	NOUN
admet-491	81	66	-0.62	-0.62	NOUN
admet-491	81	67	9.7	9.7	NUM
admet-491	81	68	100	100	NUM
admet-491	81	69	%	%	NOUN
admet-491	81	70	2	2	NUM
admet-491	81	71	-	-	PUNCT
admet-491	81	72	methyl-4,6	methyl-4,6	NOUN
admet-491	81	73	-	-	PUNCT
admet-491	81	74	dinitrophenol	dinitrophenol	NOUN
admet-491	81	75	2.13	2.13	NUM
admet-491	81	76	4.2	4.2	NUM
admet-491	81	77	99	99	NUM
admet-491	81	78	%	%	NOUN
admet-491	81	79	thiouracil	thiouracil	NOUN
admet-491	81	80	-0.28	-0.28	NUM
admet-491	81	81	7.5	7.5	NUM
admet-491	81	82	100	100	NUM
admet-491	81	83	%	%	NOUN
admet-491	81	84	cinnamic	cinnamic	ADJ
admet-491	81	85	acid	acid	NOUN
admet-491	81	86	2.13	2.13	NUM
admet-491	81	87	4.4	4.4	NUM
admet-491	81	88	100	100	NUM
admet-491	81	89	%	%	NOUN
admet-491	81	90	chlorothiazide	chlorothiazide	ADJ
admet-491	81	91	-0.24	-0.24	NOUN
admet-491	81	92	6.7	6.7	NUM
admet-491	81	93	100	100	NUM
admet-491	81	94	%	%	NOUN
admet-491	81	95	xipamide	xipamide	NOUN
admet-491	81	96	2.19	2.19	NUM
admet-491	81	97	4.8	4.8	NUM
admet-491	81	98	100	100	NUM
admet-491	81	99	%	%	NOUN
admet-491	81	100	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-491	81	101	-0.07	-0.07	NUM
admet-491	81	102	8.9	8.9	NUM
admet-491	81	103	100	100	NUM
admet-491	81	104	%	%	NOUN
admet-491	81	105	2,4	2,4	NUM
admet-491	81	106	-	-	PUNCT
admet-491	81	107	dimethylphenol	dimethylphenol	NOUN
admet-491	81	108	2.30	2.30	NUM
admet-491	81	109	10.0	10.0	NUM
admet-491	81	110	100	100	NUM
admet-491	81	111	%	%	NOUN
admet-491	81	112	theophylline	theophylline	NOUN
admet-491	81	113	-0.02	-0.02	NUM
admet-491	81	114	8.7	8.7	NUM
admet-491	81	115	100	100	NUM
admet-491	81	116	%	%	NOUN
admet-491	81	117	methyl	methyl	NOUN
admet-491	81	118	salicylate	salicylate	NOUN
admet-491	81	119	2.34	2.34	NUM
admet-491	81	120	9.8	9.8	NUM
admet-491	81	121	100	100	NUM
admet-491	81	122	%	%	NOUN
admet-491	81	123	pyrogallol	pyrogallol	NOUN
admet-491	81	124	*	*	PUNCT
admet-491	81	125	0.29	0.29	NUM
admet-491	81	126	9.0	9.0	NUM
admet-491	81	127	100	100	NUM
admet-491	81	128	%	%	NOUN
admet-491	81	129	3	3	NUM
admet-491	81	130	-	-	PUNCT
admet-491	81	131	methylbenzoic	methylbenzoic	NOUN
admet-491	81	132	acid	acid	NOUN
admet-491	81	133	2.37	2.37	NUM
admet-491	81	134	4.1	4.1	NUM
admet-491	81	135	99	99	NUM
admet-491	81	136	%	%	NOUN
admet-491	81	137	mandelic	mandelic	NOUN
admet-491	81	138	acid	acid	NOUN
admet-491	81	139	0.62	0.62	NUM
admet-491	81	140	3.4	3.4	NUM
admet-491	81	141	96	96	NUM
admet-491	81	142	%	%	NOUN
admet-491	81	143	2	2	NUM
admet-491	81	144	-	-	PUNCT
admet-491	81	145	methylbenzoic	methylbenzoic	NOUN
admet-491	81	146	acid	acid	NOUN
admet-491	81	147	2.40	2.40	NUM
admet-491	81	148	3.7	3.7	NUM
admet-491	81	149	98	98	NUM
admet-491	81	150	%	%	NOUN
admet-491	81	151	barbital	barbital	NOUN
admet-491	81	152	0.65	0.65	NUM
admet-491	81	153	7.9	7.9	NUM
admet-491	81	154	100	100	NUM
admet-491	81	155	%	%	NOUN
admet-491	81	156	estriol	estriol	NOUN
admet-491	81	157	2.54	2.54	NUM
admet-491	81	158	10.0	10.0	NUM
admet-491	81	159	100	100	NUM
admet-491	81	160	%	%	NOUN
admet-491	81	161	gallic	gallic	NOUN
admet-491	81	162	acid	acid	NOUN
admet-491	81	163	0.70	0.70	NUM
admet-491	81	164	4.3	4.3	NUM
admet-491	81	165	100	100	NUM
admet-491	81	166	%	%	NOUN
admet-491	81	167	clofibric	clofibric	ADJ
admet-491	81	168	acid	acid	NOUN
admet-491	81	169	2.57	2.57	NUM
admet-491	81	170	4.0	4.0	NUM
admet-491	81	171	99	99	NUM
admet-491	81	172	%	%	NOUN
admet-491	81	173	resorcinol	resorcinol	NOUN
admet-491	81	174	0.80	0.80	NUM
admet-491	81	175	9.6	9.6	NUM
admet-491	81	176	100	100	NUM
admet-491	81	177	%	%	NOUN
admet-491	81	178	warfarin	warfarin	NOUN
admet-491	81	179	2.70	2.70	NUM
admet-491	81	180	4.9	4.9	NUM
admet-491	81	181	100	100	NUM
admet-491	81	182	%	%	NOUN
admet-491	81	183	catechol	catechol	NOUN
admet-491	81	184	0.88	0.88	NUM
admet-491	81	185	10.0	10.0	NUM
admet-491	81	186	100	100	NUM
admet-491	81	187	%	%	NOUN
admet-491	81	188	2,4	2,4	NUM
admet-491	81	189	-	-	PUNCT
admet-491	81	190	dimethylbenzoic	dimethylbenzoic	ADJ
admet-491	81	191	acid	acid	NOUN
admet-491	81	192	*	*	NUM
admet-491	81	193	2.82	2.82	NUM
admet-491	81	194	3.7	3.7	NUM
admet-491	81	195	98	98	NUM
admet-491	81	196	%	%	NOUN
admet-491	81	197	acetylsalicylic	acetylsalicylic	NOUN
admet-491	81	198	acid	acid	NOUN
admet-491	81	199	1.19	1.19	NUM
admet-491	81	200	3.5	3.5	NUM
admet-491	81	201	97	97	NUM
admet-491	81	202	%	%	NOUN
admet-491	81	203	3	3	NUM
admet-491	81	204	-	-	PUNCT
admet-491	81	205	bromobenzoic	bromobenzoic	ADJ
admet-491	81	206	acid	acid	NOUN
admet-491	81	207	2.87	2.87	NUM
admet-491	81	208	3.6	3.6	NUM
admet-491	81	209	98	98	NUM
admet-491	81	210	%	%	NOUN
admet-491	81	211	vanillin	vanillin	NOUN
admet-491	81	212	1.21	1.21	NUM
admet-491	81	213	7.3	7.3	NUM
admet-491	81	214	100	100	NUM
admet-491	81	215	%	%	NOUN
admet-491	81	216	1	1	NUM
admet-491	81	217	-	-	PUNCT
admet-491	81	218	naphthoic	naphthoic	ADJ
admet-491	81	219	acid	acid	NOUN
admet-491	81	220	3.10	3.10	NUM
admet-491	81	221	3.5	3.5	NUM
admet-491	81	222	97	97	NUM
admet-491	81	223	%	%	NOUN
admet-491	81	224	2,6	2,6	NUM
admet-491	81	225	-	-	NOUN
admet-491	81	226	dinitrophenol	dinitrophenol	NOUN
admet-491	81	227	1.37	1.37	NUM
admet-491	81	228	3.5	3.5	NUM
admet-491	81	229	97	97	NUM
admet-491	81	230	%	%	NOUN
admet-491	81	231	ketoprofen	ketoprofen	VERB
admet-491	81	232	3.12	3.12	NUM
admet-491	81	233	4.1	4.1	NUM
admet-491	81	234	99	99	NUM
admet-491	81	235	%	%	NOUN
admet-491	81	236	phenol	phenol	NOUN
admet-491	81	237	1.47	1.47	NUM
admet-491	81	238	10.0	10.0	NUM
admet-491	81	239	100	100	NUM
admet-491	81	240	%	%	NOUN
admet-491	81	241	3,5	3,5	NUM
admet-491	81	242	-	-	PUNCT
admet-491	81	243	dichlorobenzoic	dichlorobenzoic	ADJ
admet-491	81	244	acid	acid	NOUN
admet-491	81	245	3.29	3.29	NUM
admet-491	81	246	3.3	3.3	NUM
admet-491	81	247	98	98	NUM
admet-491	81	248	%	%	NOUN
admet-491	81	249	phenobarbital	phenobarbital	ADJ
admet-491	81	250	1.47	1.47	NUM
admet-491	81	251	7.5	7.5	NUM
admet-491	81	252	100	100	NUM
admet-491	81	253	%	%	NOUN
admet-491	81	254	naproxen	naproxen	NOUN
admet-491	81	255	3.34	3.34	NUM
admet-491	81	256	7.2	7.2	NUM
admet-491	81	257	100	100	NUM
admet-491	81	258	%	%	NOUN
admet-491	81	259	carbromal	carbromal	ADJ
admet-491	81	260	1.54	1.54	NUM
admet-491	81	261	10.8	10.8	NUM
admet-491	81	262	100	100	NUM
admet-491	81	263	%	%	NOUN
admet-491	81	264	ibuprofen	ibuprofen	NOUN
admet-491	81	265	3.50	3.50	NUM
admet-491	81	266	3.5	3.5	NUM
admet-491	81	267	100	100	NUM
admet-491	81	268	%	%	NOUN
admet-491	81	269	morin	morin	NOUN
admet-491	81	270	1.54	1.54	NUM
admet-491	81	271	7.4	7.4	NUM
admet-491	81	272	100	100	NUM
admet-491	81	273	%	%	NOUN
admet-491	81	274	2,4,5	2,4,5	NUM
admet-491	81	275	-	-	PUNCT
admet-491	81	276	trichlorophenol	trichlorophenol	NOUN
admet-491	81	277	3.72	3.72	NUM
admet-491	81	278	7.9	7.9	NUM
admet-491	81	279	100	100	NUM
admet-491	81	280	%	%	NOUN
admet-491	81	281	4	4	NUM
admet-491	81	282	-	-	PUNCT
admet-491	81	283	hydroxybenzoic	hydroxybenzoic	NOUN
admet-491	81	284	acid	acid	NOUN
admet-491	81	285	1.58	1.58	NUM
admet-491	81	286	4.6	4.6	NUM
admet-491	81	287	100	100	NUM
admet-491	81	288	%	%	NOUN
admet-491	81	289	4	4	NUM
admet-491	81	290	-	-	PUNCT
admet-491	81	291	tert	tert	NOUN
admet-491	81	292	-	-	PUNCT
admet-491	81	293	butylbenzoic	butylbenzoic	ADJ
admet-491	81	294	acid	acid	NOUN
admet-491	81	295	3.85	3.85	NUM
admet-491	81	296	4.2	4.2	NUM
admet-491	81	297	99	99	NUM
admet-491	81	298	%	%	NOUN
admet-491	81	299	2,4	2,4	NUM
admet-491	81	300	-	-	PUNCT
admet-491	81	301	dinitrophenol	dinitrophenol	NOUN
admet-491	81	302	1.67	1.67	NUM
admet-491	81	303	4.2	4.2	NUM
admet-491	81	304	99	99	NUM
admet-491	81	305	%	%	NOUN
admet-491	81	306	estradiol	estradiol	PROPN
admet-491	81	307	4.01	4.01	NUM
admet-491	81	308	4.4	4.4	NUM
admet-491	81	309	100	100	NUM
admet-491	81	310	%	%	NOUN
admet-491	81	311	3	3	NUM
admet-491	81	312	-	-	PUNCT
admet-491	81	313	nitrobenzoic	nitrobenzoic	ADJ
admet-491	81	314	acid	acid	NOUN
admet-491	81	315	1.83	1.83	NUM
admet-491	81	316	3.4	3.4	NUM
admet-491	81	317	96	96	NUM
admet-491	81	318	%	%	NOUN
admet-491	81	319	diclofenac	diclofenac	NOUN
admet-491	81	320	4.50	4.50	NUM
admet-491	81	321	4.8	4.8	NUM
admet-491	81	322	100	100	NUM
admet-491	81	323	%	%	NOUN
admet-491	81	324	benzoic	benzoic	NOUN
admet-491	81	325	acid	acid	NOUN
admet-491	81	326	1.87	1.87	NUM
admet-491	81	327	4.1	4.1	NUM
admet-491	81	328	99	99	NUM
admet-491	81	329	%	%	NOUN
admet-491	81	330	*	*	PUNCT
admet-491	81	331	data	datum	NOUN
admet-491	81	332	from	from	ADP
admet-491	81	333	ref	ref	NOUN
admet-491	81	334	.	.	PUNCT
admet-491	82	1	[	[	X
admet-491	82	2	23	23	NUM
admet-491	82	3	]	]	PUNCT
admet-491	82	4	selected	select	VERB
admet-491	82	5	set	set	NOUN
admet-491	82	6	of	of	ADP
admet-491	82	7	substances	substance	NOUN
admet-491	82	8	a	a	DET
admet-491	82	9	set	set	NOUN
admet-491	82	10	of	of	ADP
admet-491	82	11	51	51	NUM
admet-491	82	12	acidic	acidic	ADJ
admet-491	82	13	substances	substance	NOUN
admet-491	82	14	,	,	PUNCT
admet-491	82	15	structurally	structurally	ADV
admet-491	82	16	different	different	ADJ
admet-491	82	17	,	,	PUNCT
admet-491	82	18	was	be	AUX
admet-491	82	19	selected	select	VERB
admet-491	82	20	for	for	ADP
admet-491	82	21	the	the	DET
admet-491	82	22	validation	validation	NOUN
admet-491	82	23	of	of	ADP
admet-491	82	24	the	the	DET
admet-491	82	25	proposed	propose	VERB
admet-491	82	26	method	method	NOUN
admet-491	82	27	(	(	PUNCT
admet-491	82	28	table	table	NOUN
admet-491	82	29	1	1	NUM
admet-491	82	30	)	)	PUNCT
admet-491	82	31	.	.	PUNCT
admet-491	83	1	they	they	PRON
admet-491	83	2	covered	cover	VERB
admet-491	83	3	a	a	DET
admet-491	83	4	wide	wide	ADJ
admet-491	83	5	region	region	NOUN
admet-491	83	6	of	of	ADP
admet-491	83	7	chemical	chemical	ADJ
admet-491	83	8	space	space	NOUN
admet-491	83	9	,	,	PUNCT
admet-491	83	10	with	with	ADP
admet-491	83	11	lipophilicity	lipophilicity	NOUN
admet-491	83	12	values	value	NOUN
admet-491	83	13	covering	cover	VERB
admet-491	83	14	5	5	NUM
admet-491	83	15	log	log	NOUN
admet-491	83	16	po	po	NOUN
admet-491	83	17	/	/	SYM
admet-491	83	18	w	w	PROPN
admet-491	83	19	units	unit	NOUN
admet-491	83	20	(	(	PUNCT
admet-491	83	21	between	between	ADP
admet-491	83	22	-1.5	-1.5	PUNCT
admet-491	83	23	and	and	CCONJ
admet-491	83	24	4.5	4.5	NUM
admet-491	83	25	)	)	PUNCT
admet-491	83	26	and	and	CCONJ
admet-491	83	27	calculated	calculate	VERB
admet-491	83	28	pka	pka	PROPN
admet-491	83	29	values	value	NOUN
admet-491	83	30	in	in	ADP
admet-491	83	31	the	the	DET
admet-491	83	32	range	range	NOUN
admet-491	83	33	between	between	ADP
admet-491	83	34	3.3	3.3	NUM
admet-491	83	35	and	and	CCONJ
admet-491	83	36	13.6	13.6	NUM
admet-491	83	37	.	.	PUNCT
admet-491	84	1	stronger	strong	ADJ
admet-491	84	2	acids	acid	NOUN
admet-491	84	3	had	have	VERB
admet-491	84	4	to	to	PART
admet-491	84	5	be	be	AUX
admet-491	84	6	excluded	exclude	VERB
admet-491	84	7	,	,	PUNCT
admet-491	84	8	since	since	SCONJ
admet-491	84	9	the	the	DET
admet-491	84	10	me	i	PRON
admet-491	84	11	employed	employ	VERB
admet-491	84	12	had	have	VERB
admet-491	84	13	a	a	DET
admet-491	84	14	ph	ph	ADJ
admet-491	84	15	value	value	NOUN
admet-491	84	16	of	of	ADP
admet-491	84	17	2.0	2.0	NUM
admet-491	84	18	and	and	CCONJ
admet-491	84	19	this	this	DET
admet-491	84	20	approach	approach	NOUN
admet-491	84	21	required	require	VERB
admet-491	84	22	the	the	DET
admet-491	84	23	solutes	solute	NOUN
admet-491	84	24	to	to	PART
admet-491	84	25	be	be	AUX
admet-491	84	26	in	in	ADP
admet-491	84	27	their	their	PRON
admet-491	84	28	neutral	neutral	ADJ
admet-491	84	29	form	form	NOUN
admet-491	84	30	(	(	PUNCT
admet-491	84	31	a	a	DET
admet-491	84	32	molar	molar	ADJ
admet-491	84	33	fraction	fraction	NOUN
admet-491	84	34	of	of	ADP
admet-491	84	35	5	5	NUM
admet-491	84	36	%	%	NOUN
admet-491	84	37	of	of	ADP
admet-491	84	38	ionized	ionized	ADJ
admet-491	84	39	species	specie	NOUN
admet-491	84	40	was	be	AUX
admet-491	84	41	set	set	VERB
admet-491	84	42	as	as	ADP
admet-491	84	43	threshold	threshold	NOUN
admet-491	84	44	)	)	PUNCT
admet-491	84	45	.	.	PUNCT
admet-491	85	1	marti	marti	PROPN
admet-491	85	2	rosés	rosés	PROPN
admet-491	85	3	et	et	PROPN
admet-491	85	4	al	al	PROPN
admet-491	85	5	.	.	PROPN
admet-491	85	6	admet	admet	PROPN
admet-491	85	7	&	&	CCONJ
admet-491	85	8	dmpk	dmpk	PROPN
admet-491	85	9	6(2	6(2	NUM
admet-491	85	10	)	)	PUNCT
admet-491	85	11	(	(	PUNCT
admet-491	85	12	2018	2018	NUM
admet-491	85	13	)	)	PUNCT
admet-491	85	14	153	153	NUM
admet-491	85	15	-	-	SYM
admet-491	85	16	161	161	NUM
admet-491	85	17	158	158	NUM
admet-491	85	18	internal	internal	ADJ
admet-491	85	19	validation	validation	NOUN
admet-491	85	20	as	as	SCONJ
admet-491	85	21	shown	show	VERB
admet-491	85	22	in	in	ADP
admet-491	85	23	figure	figure	NOUN
admet-491	85	24	1	1	NUM
admet-491	85	25	,	,	PUNCT
admet-491	85	26	there	there	PRON
admet-491	85	27	was	be	VERB
admet-491	85	28	an	an	DET
admet-491	85	29	excellent	excellent	ADJ
admet-491	85	30	correlation	correlation	NOUN
admet-491	85	31	between	between	ADP
admet-491	85	32	experimental	experimental	ADJ
admet-491	85	33	log	log	PROPN
admet-491	85	34	po	po	PROPN
admet-491	85	35	/	/	SYM
admet-491	85	36	w	w	NOUN
admet-491	85	37	values	value	NOUN
admet-491	85	38	found	find	VERB
admet-491	85	39	in	in	ADP
admet-491	85	40	the	the	DET
admet-491	85	41	literature	literature	NOUN
admet-491	85	42	and	and	CCONJ
admet-491	85	43	log	log	VERB
admet-491	85	44	kmeekc	kmeekc	PROPN
admet-491	85	45	measurements	measurement	NOUN
admet-491	85	46	performed	perform	VERB
admet-491	85	47	in	in	ADP
admet-491	85	48	the	the	DET
admet-491	85	49	present	present	ADJ
admet-491	85	50	work	work	NOUN
admet-491	85	51	.	.	PUNCT
admet-491	86	1	the	the	DET
admet-491	86	2	model	model	NOUN
admet-491	86	3	successfully	successfully	ADV
admet-491	86	4	explained	explain	VERB
admet-491	86	5	92.75	92.75	NUM
admet-491	86	6	%	%	NOUN
admet-491	86	7	of	of	ADP
admet-491	86	8	the	the	DET
admet-491	86	9	log	log	NOUN
admet-491	86	10	po	po	NOUN
admet-491	86	11	/	/	SYM
admet-491	86	12	w	w	NOUN
admet-491	86	13	variation	variation	NOUN
admet-491	86	14	in	in	ADP
admet-491	86	15	the	the	DET
admet-491	86	16	selected	select	VERB
admet-491	86	17	set	set	NOUN
admet-491	86	18	of	of	ADP
admet-491	86	19	compounds	compound	NOUN
admet-491	86	20	,	,	PUNCT
admet-491	86	21	and	and	CCONJ
admet-491	86	22	the	the	DET
admet-491	86	23	summarized	summarize	VERB
admet-491	86	24	overall	overall	ADJ
admet-491	86	25	error	error	NOUN
admet-491	86	26	in	in	ADP
admet-491	86	27	the	the	DET
admet-491	86	28	prediction	prediction	NOUN
admet-491	86	29	of	of	ADP
admet-491	86	30	the	the	DET
admet-491	86	31	model	model	NOUN
admet-491	86	32	(	(	PUNCT
admet-491	86	33	0.38	0.38	NUM
admet-491	86	34	)	)	PUNCT
admet-491	86	35	is	be	AUX
admet-491	86	36	only	only	ADV
admet-491	86	37	slightly	slightly	ADV
admet-491	86	38	higher	high	ADJ
admet-491	86	39	than	than	ADP
admet-491	86	40	the	the	DET
admet-491	86	41	admitted	admit	VERB
admet-491	86	42	differences	difference	NOUN
admet-491	86	43	from	from	ADP
admet-491	86	44	log	log	PROPN
admet-491	86	45	po	po	PROPN
admet-491	86	46	/	/	SYM
admet-491	86	47	w	w	NOUN
admet-491	86	48	replicates	replicate	NOUN
admet-491	86	49	by	by	ADP
admet-491	86	50	the	the	DET
admet-491	86	51	shake	shake	NOUN
admet-491	86	52	-	-	PUNCT
admet-491	86	53	flask	flask	NOUN
admet-491	86	54	methods	method	NOUN
admet-491	86	55	[	[	X
admet-491	86	56	3,24	3,24	X
admet-491	86	57	]	]	X
admet-491	86	58	.	.	PUNCT
admet-491	87	1	only	only	ADV
admet-491	87	2	three	three	NUM
admet-491	87	3	compounds	compound	NOUN
admet-491	87	4	presented	present	VERB
admet-491	87	5	higher	high	ADJ
admet-491	87	6	errors	error	NOUN
admet-491	87	7	than	than	ADP
admet-491	87	8	two	two	NUM
admet-491	87	9	times	time	NOUN
admet-491	87	10	the	the	DET
admet-491	87	11	standard	standard	ADJ
admet-491	87	12	error	error	NOUN
admet-491	87	13	of	of	ADP
admet-491	87	14	the	the	DET
admet-491	87	15	fitting	fitting	NOUN
admet-491	87	16	;	;	PUNCT
admet-491	87	17	these	these	PRON
admet-491	87	18	were	be	AUX
admet-491	87	19	2,4	2,4	NUM
admet-491	87	20	-	-	PUNCT
admet-491	87	21	dithiouracil	dithiouracil	NOUN
admet-491	87	22	,	,	PUNCT
admet-491	87	23	hydroxypropyltheophylline	hydroxypropyltheophylline	NOUN
admet-491	87	24	,	,	PUNCT
admet-491	87	25	and	and	CCONJ
admet-491	87	26	morin	morin	NOUN
admet-491	87	27	.	.	PUNCT
admet-491	88	1	in	in	ADP
admet-491	88	2	all	all	DET
admet-491	88	3	cases	case	NOUN
admet-491	88	4	,	,	PUNCT
admet-491	88	5	predicted	predict	VERB
admet-491	88	6	log	log	NOUN
admet-491	88	7	po	po	PROPN
admet-491	88	8	/	/	SYM
admet-491	88	9	w	w	NOUN
admet-491	88	10	values	value	NOUN
admet-491	88	11	were	be	AUX
admet-491	88	12	higher	high	ADJ
admet-491	88	13	(	(	PUNCT
admet-491	88	14	1.2	1.2	NUM
admet-491	88	15	,	,	PUNCT
admet-491	88	16	0.9	0.9	NUM
admet-491	88	17	,	,	PUNCT
admet-491	88	18	and	and	CCONJ
admet-491	88	19	2.5	2.5	NUM
admet-491	88	20	,	,	PUNCT
admet-491	88	21	respectively	respectively	ADV
admet-491	88	22	)	)	PUNCT
admet-491	88	23	than	than	ADP
admet-491	88	24	those	those	PRON
admet-491	88	25	found	find	VERB
admet-491	88	26	in	in	ADP
admet-491	88	27	the	the	DET
admet-491	88	28	literature	literature	NOUN
admet-491	88	29	.	.	PUNCT
admet-491	89	1	figure	figure	NOUN
admet-491	89	2	1	1	NUM
admet-491	89	3	.	.	PUNCT
admet-491	89	4	correlation	correlation	NOUN
admet-491	89	5	between	between	ADP
admet-491	89	6	log	log	PROPN
admet-491	89	7	po	po	PROPN
admet-491	89	8	/	/	SYM
admet-491	89	9	w	w	PROPN
admet-491	89	10	and	and	CCONJ
admet-491	89	11	log	log	VERB
admet-491	89	12	kmeekc	kmeekc	PROPN
admet-491	89	13	values	value	NOUN
admet-491	89	14	for	for	ADP
admet-491	89	15	the	the	DET
admet-491	89	16	acidic	acidic	ADJ
admet-491	89	17	compound	compound	NOUN
admet-491	89	18	studied	study	VERB
admet-491	89	19	(	(	PUNCT
admet-491	89	20	table	table	NOUN
admet-491	89	21	1	1	NUM
admet-491	89	22	)	)	PUNCT
admet-491	89	23	.	.	PUNCT
admet-491	90	1	statistical	statistical	ADJ
admet-491	90	2	parameters	parameter	NOUN
admet-491	90	3	for	for	ADP
admet-491	90	4	the	the	DET
admet-491	90	5	fitting	fitting	ADJ
admet-491	90	6	(	(	PUNCT
admet-491	90	7	correlation	correlation	NOUN
admet-491	90	8	coefficient	coefficient	NOUN
admet-491	90	9	,	,	PUNCT
admet-491	90	10	root	root	NOUN
admet-491	90	11	mean	mean	VERB
admet-491	90	12	square	square	NOUN
admet-491	90	13	error	error	NOUN
admet-491	90	14	,	,	PUNCT
admet-491	90	15	and	and	CCONJ
admet-491	90	16	the	the	DET
admet-491	90	17	fisher	fisher	PROPN
admet-491	90	18	statistic	statistic	PROPN
admet-491	90	19	)	)	PUNCT
admet-491	90	20	are	be	AUX
admet-491	90	21	also	also	ADV
admet-491	90	22	shown	show	VERB
admet-491	90	23	.	.	PUNCT
admet-491	91	1	legend	legend	NOUN
admet-491	91	2	:	:	PUNCT
admet-491	91	3	(	(	PUNCT
admet-491	91	4	■	■	NOUN
admet-491	91	5	)	)	PUNCT
admet-491	91	6	pka	pka	PROPN
admet-491	91	7	≤	≤	NUM
admet-491	91	8	4.0	4.0	NUM
admet-491	91	9	,	,	PUNCT
admet-491	91	10	(	(	PUNCT
admet-491	91	11	●	●	NOUN
admet-491	91	12	)	)	PUNCT
admet-491	91	13	4.0	4.0	NUM
admet-491	91	14	<	<	X
admet-491	91	15	pka	pka	PROPN
admet-491	91	16	≤	≤	NUM
admet-491	91	17	6.0	6.0	NUM
admet-491	91	18	,	,	PUNCT
admet-491	91	19	(	(	PUNCT
admet-491	91	20	▲	▲	PUNCT
admet-491	91	21	)	)	PUNCT
admet-491	91	22	6.0	6.0	NUM
admet-491	91	23	<	<	X
admet-491	91	24	pka	pka	PROPN
admet-491	91	25	≤	≤	NUM
admet-491	91	26	8.0	8.0	NUM
admet-491	91	27	,	,	PUNCT
admet-491	91	28	and	and	CCONJ
admet-491	91	29	(	(	PUNCT
admet-491	91	30	▼	▼	NOUN
admet-491	91	31	)	)	PUNCT
admet-491	91	32	pka	pka	PROPN
admet-491	91	33	>	>	X
admet-491	91	34	8.0	8.0	NUM
admet-491	91	35	.	.	PUNCT
admet-491	92	1	since	since	SCONJ
admet-491	92	2	the	the	DET
admet-491	92	3	validated	validate	VERB
admet-491	92	4	model	model	NOUN
admet-491	92	5	presents	present	VERB
admet-491	92	6	only	only	ADV
admet-491	92	7	one	one	NUM
admet-491	92	8	independent	independent	ADJ
admet-491	92	9	variable	variable	NOUN
admet-491	92	10	(	(	PUNCT
admet-491	92	11	log	log	PROPN
admet-491	92	12	kmeekc	kmeekc	PROPN
admet-491	92	13	)	)	PUNCT
admet-491	92	14	,	,	PUNCT
admet-491	92	15	as	as	SCONJ
admet-491	92	16	expected	expect	VERB
admet-491	92	17	the	the	DET
admet-491	92	18	crossvalidated	crossvalidate	VERB
admet-491	92	19	correlation	correlation	NOUN
admet-491	92	20	coefficients	coefficient	NOUN
admet-491	92	21	q2	q2	PROPN
admet-491	92	22	loo	loo	PROPN
admet-491	92	23	(	(	PUNCT
admet-491	92	24	0.9211	0.9211	NUM
admet-491	92	25	)	)	PUNCT
admet-491	92	26	was	be	AUX
admet-491	92	27	only	only	ADV
admet-491	92	28	slightly	slightly	ADV
admet-491	92	29	lower	low	ADJ
admet-491	92	30	than	than	ADP
admet-491	92	31	the	the	DET
admet-491	92	32	fitting	fitting	ADJ
admet-491	92	33	parameter	parameter	NOUN
admet-491	92	34	r2	r2	PROPN
admet-491	92	35	(	(	PUNCT
admet-491	92	36	0.9275	0.9275	NUM
admet-491	92	37	)	)	PUNCT
admet-491	92	38	,	,	PUNCT
admet-491	92	39	being	be	AUX
admet-491	92	40	all	all	PRON
admet-491	92	41	of	of	ADP
admet-491	92	42	them	they	PRON
admet-491	92	43	significantly	significantly	ADV
admet-491	92	44	much	much	ADV
admet-491	92	45	higher	high	ADJ
admet-491	92	46	than	than	ADP
admet-491	92	47	the	the	DET
admet-491	92	48	0.7	0.7	NUM
admet-491	92	49	threshold	threshold	NOUN
admet-491	92	50	.	.	PUNCT
admet-491	93	1	the	the	DET
admet-491	93	2	mean	mean	PROPN
admet-491	93	3	q2	q2	PROPN
admet-491	93	4	lmo	lmo	PROPN
admet-491	93	5	,	,	PUNCT
admet-491	93	6	which	which	PRON
admet-491	93	7	was	be	AUX
admet-491	93	8	calculated	calculate	VERB
admet-491	93	9	from	from	ADP
admet-491	93	10	2000	2000	NUM
admet-491	93	11	iterations	iteration	NOUN
admet-491	93	12	excluding	exclude	VERB
admet-491	93	13	randomly	randomly	ADV
admet-491	93	14	50	50	NUM
admet-491	93	15	%	%	NOUN
admet-491	93	16	of	of	ADP
admet-491	93	17	the	the	DET
admet-491	93	18	chemicals	chemical	NOUN
admet-491	93	19	of	of	ADP
admet-491	93	20	the	the	DET
admet-491	93	21	set	set	NOUN
admet-491	93	22	,	,	PUNCT
admet-491	93	23	presented	present	VERB
admet-491	93	24	a	a	DET
admet-491	93	25	value	value	NOUN
admet-491	93	26	of	of	ADP
admet-491	93	27	0.915	0.915	NUM
admet-491	93	28	with	with	ADP
admet-491	93	29	a	a	DET
admet-491	93	30	standard	standard	ADJ
admet-491	93	31	deviation	deviation	NOUN
admet-491	93	32	of	of	ADP
admet-491	93	33	0.023	0.023	NUM
admet-491	93	34	,	,	PUNCT
admet-491	93	35	being	be	AUX
admet-491	93	36	thus	thus	ADV
admet-491	93	37	very	very	ADV
admet-491	93	38	close	close	ADJ
admet-491	93	39	to	to	ADP
admet-491	93	40	q2	q2	NOUN
admet-491	93	41	loo	loo	NOUN
admet-491	93	42	and	and	CCONJ
admet-491	93	43	with	with	ADP
admet-491	93	44	a	a	DET
admet-491	93	45	low	low	ADJ
admet-491	93	46	dispersion	dispersion	NOUN
admet-491	93	47	.	.	PUNCT
admet-491	94	1	therefore	therefore	ADV
admet-491	94	2	,	,	PUNCT
admet-491	94	3	internal	internal	ADJ
admet-491	94	4	validation	validation	NOUN
admet-491	94	5	demonstrated	demonstrate	VERB
admet-491	94	6	that	that	SCONJ
admet-491	94	7	the	the	DET
admet-491	94	8	model	model	NOUN
admet-491	94	9	was	be	AUX
admet-491	94	10	stable	stable	ADJ
admet-491	94	11	and	and	CCONJ
admet-491	94	12	internally	internally	ADV
admet-491	94	13	predictive	predictive	ADJ
admet-491	94	14	,	,	PUNCT
admet-491	94	15	and	and	CCONJ
admet-491	94	16	thus	thus	ADV
admet-491	94	17	ready	ready	ADJ
admet-491	94	18	for	for	ADP
admet-491	94	19	the	the	DET
admet-491	94	20	external	external	ADJ
admet-491	94	21	validation	validation	NOUN
admet-491	94	22	step	step	NOUN
admet-491	94	23	.	.	PUNCT
admet-491	95	1	external	external	ADJ
admet-491	95	2	validation	validation	NOUN
admet-491	95	3	the	the	DET
admet-491	95	4	application	application	NOUN
admet-491	95	5	of	of	ADP
admet-491	95	6	this	this	DET
admet-491	95	7	method	method	NOUN
admet-491	95	8	for	for	ADP
admet-491	95	9	log	log	PROPN
admet-491	95	10	po	po	PROPN
admet-491	95	11	/	/	SYM
admet-491	95	12	w	w	NOUN
admet-491	95	13	determination	determination	NOUN
admet-491	95	14	requires	require	VERB
admet-491	95	15	first	first	ADV
admet-491	95	16	the	the	DET
admet-491	95	17	calibration	calibration	NOUN
admet-491	95	18	of	of	ADP
admet-491	95	19	the	the	DET
admet-491	95	20	response	response	NOUN
admet-491	95	21	of	of	ADP
admet-491	95	22	the	the	DET
admet-491	95	23	electrophoretic	electrophoretic	ADJ
admet-491	95	24	system	system	NOUN
admet-491	95	25	according	accord	VERB
admet-491	95	26	to	to	ADP
admet-491	95	27	equation	equation	NOUN
admet-491	95	28	(	(	PUNCT
admet-491	95	29	2	2	NUM
admet-491	95	30	)	)	PUNCT
admet-491	95	31	.	.	PUNCT
admet-491	96	1	thus	thus	ADV
admet-491	96	2	,	,	PUNCT
admet-491	96	3	it	it	PRON
admet-491	96	4	would	would	AUX
admet-491	96	5	be	be	AUX
admet-491	96	6	convenient	convenient	ADJ
admet-491	96	7	to	to	PART
admet-491	96	8	define	define	VERB
admet-491	96	9	a	a	DET
admet-491	96	10	small	small	ADJ
admet-491	96	11	set	set	NOUN
admet-491	96	12	of	of	ADP
admet-491	96	13	standards	standard	NOUN
admet-491	96	14	in	in	ADP
admet-491	96	15	order	order	NOUN
admet-491	96	16	to	to	PART
admet-491	96	17	allow	allow	VERB
admet-491	96	18	system	system	NOUN
admet-491	96	19	calibration	calibration	NOUN
admet-491	96	20	using	use	VERB
admet-491	96	21	a	a	DET
admet-491	96	22	single	single	ADJ
admet-491	96	23	injection	injection	NOUN
admet-491	96	24	of	of	ADP
admet-491	96	25	a	a	DET
admet-491	96	26	mixture	mixture	NOUN
admet-491	96	27	of	of	ADP
admet-491	96	28	these	these	DET
admet-491	96	29	compounds	compound	NOUN
admet-491	96	30	.	.	PUNCT
admet-491	97	1	with	with	ADP
admet-491	97	2	the	the	DET
admet-491	97	3	aim	aim	NOUN
admet-491	97	4	of	of	ADP
admet-491	97	5	finding	find	VERB
admet-491	97	6	a	a	DET
admet-491	97	7	suitable	suitable	ADJ
admet-491	97	8	set	set	NOUN
admet-491	97	9	,	,	PUNCT
admet-491	97	10	the	the	DET
admet-491	97	11	three	three	NUM
admet-491	97	12	compounds	compound	NOUN
admet-491	97	13	identified	identify	VERB
admet-491	97	14	as	as	ADP
admet-491	97	15	possible	possible	ADJ
admet-491	97	16	outliers	outlier	NOUN
admet-491	97	17	(	(	PUNCT
admet-491	97	18	2,4	2,4	NUM
admet-491	97	19	-	-	PUNCT
admet-491	97	20	dithiouracil	dithiouracil	NOUN
admet-491	97	21	,	,	PUNCT
admet-491	97	22	hydroxypropyltheophylline	hydroxypropyltheophylline	NOUN
admet-491	97	23	,	,	PUNCT
admet-491	97	24	and	and	CCONJ
admet-491	97	25	morin	morin	NOUN
admet-491	97	26	)	)	PUNCT
admet-491	97	27	were	be	AUX
admet-491	97	28	left	leave	VERB
admet-491	97	29	out	out	ADP
admet-491	97	30	and	and	CCONJ
admet-491	97	31	a	a	DET
admet-491	97	32	new	new	ADJ
admet-491	97	33	linear	linear	NOUN
admet-491	97	34	regression	regression	NOUN
admet-491	97	35	log	log	NOUN
admet-491	97	36	po	po	NOUN
admet-491	97	37	/	/	SYM
admet-491	97	38	w	w	PROPN
admet-491	97	39	vs.	vs.	ADP
admet-491	97	40	log	log	NOUN
admet-491	97	41	kmeekc	kmeekc	PROPN
admet-491	97	42	was	be	AUX
admet-491	97	43	calculated	calculate	VERB
admet-491	97	44	.	.	PUNCT
admet-491	98	1	four	four	NUM
admet-491	98	2	compounds	compound	NOUN
admet-491	98	3	covering	cover	VERB
admet-491	98	4	a	a	DET
admet-491	98	5	good	good	ADJ
admet-491	98	6	range	range	NOUN
admet-491	98	7	of	of	ADP
admet-491	98	8	lipophilicities	lipophilicitie	NOUN
admet-491	98	9	and	and	CCONJ
admet-491	98	10	showing	show	VERB
admet-491	98	11	very	very	ADV
admet-491	98	12	little	little	ADJ
admet-491	98	13	residuals	residual	NOUN
admet-491	98	14	were	be	AUX
admet-491	98	15	then	then	ADV
admet-491	98	16	selected	select	VERB
admet-491	98	17	as	as	ADP
admet-491	98	18	candidates	candidate	NOUN
admet-491	98	19	for	for	ADP
admet-491	98	20	the	the	DET
admet-491	98	21	calibration	calibration	NOUN
admet-491	98	22	curve	curve	NOUN
admet-491	98	23	and	and	CCONJ
admet-491	98	24	,	,	PUNCT
admet-491	98	25	consequently	consequently	ADV
admet-491	98	26	,	,	PUNCT
admet-491	98	27	as	as	ADP
admet-491	98	28	the	the	DET
admet-491	98	29	training	training	NOUN
admet-491	98	30	set	set	NOUN
admet-491	98	31	for	for	ADP
admet-491	98	32	the	the	DET
admet-491	98	33	external	external	ADJ
admet-491	98	34	validation	validation	NOUN
admet-491	98	35	.	.	PUNCT
admet-491	99	1	the	the	DET
admet-491	99	2	chosen	choose	VERB
admet-491	99	3	analytes	analyte	NOUN
admet-491	99	4	and	and	CCONJ
admet-491	99	5	the	the	DET
admet-491	99	6	calibration	calibration	NOUN
admet-491	99	7	plots	plot	NOUN
admet-491	99	8	obtained	obtain	VERB
admet-491	99	9	with	with	ADP
admet-491	99	10	the	the	DET
admet-491	99	11	equation	equation	NOUN
admet-491	99	12	are	be	AUX
admet-491	99	13	shown	show	VERB
admet-491	99	14	in	in	ADP
admet-491	99	15	figure	figure	NOUN
admet-491	99	16	2	2	NUM
admet-491	99	17	.	.	PUNCT
admet-491	100	1	after	after	ADP
admet-491	100	2	developing	develop	VERB
admet-491	100	3	the	the	DET
admet-491	100	4	model	model	NOUN
admet-491	100	5	with	with	ADP
admet-491	100	6	the	the	DET
admet-491	100	7	training	training	NOUN
admet-491	100	8	set	set	NOUN
admet-491	100	9	,	,	PUNCT
admet-491	100	10	the	the	DET
admet-491	100	11	44	44	NUM
admet-491	100	12	remaining	remain	VERB
admet-491	100	13	compounds	compound	NOUN
admet-491	100	14	(	(	PUNCT
admet-491	100	15	excluding	exclude	VERB
admet-491	100	16	the	the	DET
admet-491	100	17	three	three	NUM
admet-491	100	18	admet	admet	NOUN
admet-491	100	19	&	&	CCONJ
admet-491	100	20	dmpk	dmpk	PROPN
admet-491	100	21	6(2	6(2	NUM
admet-491	100	22	)	)	PUNCT
admet-491	100	23	(	(	PUNCT
admet-491	100	24	2018	2018	NUM
admet-491	100	25	)	)	PUNCT
admet-491	100	26	153	153	NUM
admet-491	100	27	-	-	SYM
admet-491	100	28	161	161	NUM
admet-491	100	29	lipophylicity	lipophylicity	NOUN
admet-491	100	30	determination	determination	NOUN
admet-491	100	31	of	of	ADP
admet-491	100	32	acidic	acidic	ADJ
admet-491	100	33	compounds	compound	NOUN
admet-491	100	34	by	by	ADP
admet-491	100	35	meekc	meekc	ADJ
admet-491	100	36	doi	doi	PROPN
admet-491	100	37	:	:	PUNCT
admet-491	100	38	10.5599	10.5599	NUM
admet-491	100	39	/	/	SYM
admet-491	100	40	admet.491	admet.491	PROPN
admet-491	100	41	159	159	NUM
admet-491	100	42	outliers	outlier	NOUN
admet-491	100	43	)	)	PUNCT
admet-491	100	44	were	be	AUX
admet-491	100	45	used	use	VERB
admet-491	100	46	as	as	ADP
admet-491	100	47	a	a	DET
admet-491	100	48	test	test	NOUN
admet-491	100	49	set	set	NOUN
admet-491	100	50	.	.	PUNCT
admet-491	101	1	in	in	ADP
admet-491	101	2	a	a	DET
admet-491	101	3	strict	strict	ADJ
admet-491	101	4	sense	sense	NOUN
admet-491	101	5	this	this	PRON
admet-491	101	6	was	be	AUX
admet-491	101	7	not	not	PART
admet-491	101	8	a	a	DET
admet-491	101	9	proper	proper	ADJ
admet-491	101	10	external	external	ADJ
admet-491	101	11	validation	validation	NOUN
admet-491	101	12	,	,	PUNCT
admet-491	101	13	since	since	SCONJ
admet-491	101	14	the	the	DET
admet-491	101	15	chemicals	chemical	NOUN
admet-491	101	16	belonging	belong	VERB
admet-491	101	17	to	to	ADP
admet-491	101	18	the	the	DET
admet-491	101	19	test	test	NOUN
admet-491	101	20	set	set	NOUN
admet-491	101	21	had	have	AUX
admet-491	101	22	been	be	AUX
admet-491	101	23	included	include	VERB
admet-491	101	24	in	in	ADP
admet-491	101	25	the	the	DET
admet-491	101	26	previous	previous	ADJ
admet-491	101	27	step	step	NOUN
admet-491	101	28	leading	lead	VERB
admet-491	101	29	to	to	ADP
admet-491	101	30	the	the	DET
admet-491	101	31	selection	selection	NOUN
admet-491	101	32	of	of	ADP
admet-491	101	33	the	the	DET
admet-491	101	34	four	four	NUM
admet-491	101	35	training	training	NOUN
admet-491	101	36	set	set	VERB
admet-491	101	37	compounds	compound	NOUN
admet-491	101	38	,	,	PUNCT
admet-491	101	39	thus	thus	ADV
admet-491	101	40	not	not	PART
admet-491	101	41	being	be	AUX
admet-491	101	42	completely	completely	ADV
admet-491	101	43	new	new	ADJ
admet-491	101	44	molecules	molecule	NOUN
admet-491	101	45	.	.	PUNCT
admet-491	102	1	however	however	ADV
admet-491	102	2	,	,	PUNCT
admet-491	102	3	the	the	DET
admet-491	102	4	aim	aim	NOUN
admet-491	102	5	of	of	ADP
admet-491	102	6	this	this	DET
admet-491	102	7	validation	validation	NOUN
admet-491	102	8	was	be	AUX
admet-491	102	9	to	to	PART
admet-491	102	10	prove	prove	VERB
admet-491	102	11	the	the	DET
admet-491	102	12	predictive	predictive	ADJ
admet-491	102	13	capacity	capacity	NOUN
admet-491	102	14	of	of	ADP
admet-491	102	15	the	the	DET
admet-491	102	16	standard	standard	ADJ
admet-491	102	17	compounds	compound	NOUN
admet-491	102	18	selected	select	VERB
admet-491	102	19	for	for	ADP
admet-491	102	20	the	the	DET
admet-491	102	21	calibration	calibration	NOUN
admet-491	102	22	of	of	ADP
admet-491	102	23	the	the	DET
admet-491	102	24	lipophilicity	lipophilicity	NOUN
admet-491	102	25	response	response	NOUN
admet-491	102	26	of	of	ADP
admet-491	102	27	the	the	DET
admet-491	102	28	meekc	meekc	ADJ
admet-491	102	29	system	system	NOUN
admet-491	102	30	.	.	PUNCT
admet-491	103	1	as	as	SCONJ
admet-491	103	2	shown	show	VERB
admet-491	103	3	in	in	ADP
admet-491	103	4	figure	figure	NOUN
admet-491	103	5	3	3	NUM
admet-491	103	6	,	,	PUNCT
admet-491	103	7	there	there	PRON
admet-491	103	8	was	be	VERB
admet-491	103	9	an	an	DET
admet-491	103	10	excellent	excellent	ADJ
admet-491	103	11	correspondence	correspondence	NOUN
admet-491	103	12	between	between	ADP
admet-491	103	13	predicted	predict	VERB
admet-491	103	14	and	and	CCONJ
admet-491	103	15	observed	observe	VERB
admet-491	103	16	log	log	NOUN
admet-491	103	17	po	po	PROPN
admet-491	103	18	/	/	SYM
admet-491	103	19	w	w	NOUN
admet-491	103	20	values	value	NOUN
admet-491	103	21	,	,	PUNCT
admet-491	103	22	the	the	DET
admet-491	103	23	slopes	slope	NOUN
admet-491	103	24	of	of	ADP
admet-491	103	25	the	the	DET
admet-491	103	26	normal	normal	ADJ
admet-491	103	27	regressions	regression	NOUN
admet-491	103	28	and	and	CCONJ
admet-491	103	29	that	that	SCONJ
admet-491	103	30	forced	force	VERB
admet-491	103	31	to	to	ADP
admet-491	103	32	the	the	DET
admet-491	103	33	origin	origin	NOUN
admet-491	103	34	being	be	AUX
admet-491	103	35	not	not	PART
admet-491	103	36	different	different	ADJ
admet-491	103	37	from	from	ADP
admet-491	103	38	1	1	NUM
admet-491	103	39	.	.	PUNCT
admet-491	104	1	moreover	moreover	ADV
admet-491	104	2	,	,	PUNCT
admet-491	104	3	(	(	PUNCT
admet-491	104	4	r2	r2	NOUN
admet-491	104	5	-	-	PUNCT
admet-491	104	6	r0	r0	NOUN
admet-491	104	7	2)/r2	2)/r2	NUM
admet-491	104	8	presented	present	VERB
admet-491	104	9	a	a	DET
admet-491	104	10	value	value	NOUN
admet-491	104	11	of	of	ADP
admet-491	104	12	0.002	0.002	NUM
admet-491	104	13	,	,	PUNCT
admet-491	104	14	suggesting	suggest	VERB
admet-491	104	15	that	that	SCONJ
admet-491	104	16	the	the	DET
admet-491	104	17	origin	origin	NOUN
admet-491	104	18	ordinate	ordinate	NOUN
admet-491	104	19	was	be	AUX
admet-491	104	20	not	not	PART
admet-491	104	21	significantly	significantly	ADV
admet-491	104	22	different	different	ADJ
admet-491	104	23	from	from	ADP
admet-491	104	24	0	0	NUM
admet-491	104	25	.	.	PUNCT
admet-491	105	1	in	in	ADP
admet-491	105	2	addition	addition	NOUN
admet-491	105	3	,	,	PUNCT
admet-491	105	4	the	the	DET
admet-491	105	5	value	value	NOUN
admet-491	105	6	for	for	ADP
admet-491	105	7	ccc	ccc	PROPN
admet-491	105	8	was	be	AUX
admet-491	105	9	0.974	0.974	NUM
admet-491	105	10	,	,	PUNCT
admet-491	105	11	pointing	point	VERB
admet-491	105	12	out	out	ADP
admet-491	105	13	the	the	DET
admet-491	105	14	very	very	ADV
admet-491	105	15	good	good	ADJ
admet-491	105	16	accuracy	accuracy	NOUN
admet-491	105	17	of	of	ADP
admet-491	105	18	the	the	DET
admet-491	105	19	model	model	NOUN
admet-491	105	20	in	in	ADP
admet-491	105	21	terms	term	NOUN
admet-491	105	22	of	of	ADP
admet-491	105	23	precision	precision	NOUN
admet-491	105	24	(	(	PUNCT
admet-491	105	25	scattering	scatter	VERB
admet-491	105	26	of	of	ADP
admet-491	105	27	observation	observation	NOUN
admet-491	105	28	in	in	ADP
admet-491	105	29	relation	relation	NOUN
admet-491	105	30	to	to	ADP
admet-491	105	31	the	the	DET
admet-491	105	32	fitting	fitting	ADJ
admet-491	105	33	line	line	NOUN
admet-491	105	34	)	)	PUNCT
admet-491	105	35	and	and	CCONJ
admet-491	105	36	trueness	trueness	NOUN
admet-491	105	37	(	(	PUNCT
admet-491	105	38	closeness	closeness	NOUN
admet-491	105	39	of	of	ADP
admet-491	105	40	the	the	DET
admet-491	105	41	regression	regression	NOUN
admet-491	105	42	to	to	ADP
admet-491	105	43	the	the	DET
admet-491	105	44	full	full	ADJ
admet-491	105	45	correspondence	correspondence	NOUN
admet-491	105	46	represented	represent	VERB
admet-491	105	47	by	by	ADP
admet-491	105	48	a	a	DET
admet-491	105	49	line	line	NOUN
admet-491	105	50	of	of	ADP
admet-491	105	51	slope	slope	NOUN
admet-491	105	52	1	1	NUM
admet-491	105	53	and	and	CCONJ
admet-491	105	54	intercept	intercept	NOUN
admet-491	105	55	0	0	NUM
admet-491	105	56	)	)	PUNCT
admet-491	105	57	.	.	PUNCT
admet-491	106	1	figure	figure	NOUN
admet-491	106	2	2	2	NUM
admet-491	106	3	.	.	X
admet-491	106	4	electropherogram	electropherogram	NOUN
admet-491	106	5	of	of	ADP
admet-491	106	6	the	the	DET
admet-491	106	7	mixture	mixture	NOUN
admet-491	106	8	of	of	ADP
admet-491	106	9	compounds	compound	NOUN
admet-491	106	10	selected	select	VERB
admet-491	106	11	as	as	ADP
admet-491	106	12	training	training	NOUN
admet-491	106	13	set	set	NOUN
admet-491	106	14	for	for	ADP
admet-491	106	15	the	the	DET
admet-491	106	16	external	external	ADJ
admet-491	106	17	validation	validation	NOUN
admet-491	106	18	and	and	CCONJ
admet-491	106	19	the	the	DET
admet-491	106	20	calibration	calibration	NOUN
admet-491	106	21	plot	plot	NOUN
admet-491	106	22	used	use	VERB
admet-491	106	23	as	as	ADP
admet-491	106	24	model	model	NOUN
admet-491	106	25	development	development	NOUN
admet-491	106	26	(	(	PUNCT
admet-491	106	27	dashed	dash	VERB
admet-491	106	28	line	line	NOUN
admet-491	106	29	)	)	PUNCT
admet-491	106	30	.	.	PUNCT
admet-491	107	1	figure	figure	VERB
admet-491	107	2	3	3	NUM
admet-491	107	3	.	.	PUNCT
admet-491	107	4	correlation	correlation	NOUN
admet-491	107	5	between	between	ADP
admet-491	107	6	observed	observe	VERB
admet-491	107	7	and	and	CCONJ
admet-491	107	8	predicted	predict	VERB
admet-491	107	9	log	log	PROPN
admet-491	107	10	po	po	PROPN
admet-491	107	11	/	/	SYM
admet-491	107	12	w	w	PROPN
admet-491	107	13	from	from	ADP
admet-491	107	14	external	external	ADJ
admet-491	107	15	validation	validation	NOUN
admet-491	107	16	.	.	PUNCT
admet-491	108	1	dashed	dash	VERB
admet-491	108	2	line	line	NOUN
admet-491	108	3	represents	represent	VERB
admet-491	108	4	the	the	DET
admet-491	108	5	regression	regression	NOUN
admet-491	108	6	forcing	force	VERB
admet-491	108	7	the	the	DET
admet-491	108	8	null	null	ADJ
admet-491	108	9	origin	origin	NOUN
admet-491	108	10	.	.	PUNCT
admet-491	109	1	marti	marti	PROPN
admet-491	109	2	rosés	rosés	PROPN
admet-491	109	3	et	et	PROPN
admet-491	109	4	al	al	PROPN
admet-491	109	5	.	.	PROPN
admet-491	109	6	admet	admet	PROPN
admet-491	109	7	&	&	CCONJ
admet-491	109	8	dmpk	dmpk	PROPN
admet-491	109	9	6(2	6(2	NUM
admet-491	109	10	)	)	PUNCT
admet-491	109	11	(	(	PUNCT
admet-491	109	12	2018	2018	NUM
admet-491	109	13	)	)	PUNCT
admet-491	109	14	153	153	NUM
admet-491	109	15	-	-	SYM
admet-491	109	16	161	161	NUM
admet-491	109	17	160	160	NUM
admet-491	109	18	conclusions	conclusion	NOUN
admet-491	109	19	in	in	ADP
admet-491	109	20	contrast	contrast	NOUN
admet-491	109	21	to	to	ADP
admet-491	109	22	hplc	hplc	NOUN
admet-491	109	23	methods	method	NOUN
admet-491	109	24	,	,	PUNCT
admet-491	109	25	meekc	meekc	ADJ
admet-491	109	26	measurements	measurement	NOUN
admet-491	109	27	can	can	AUX
admet-491	109	28	be	be	AUX
admet-491	109	29	accurately	accurately	ADV
admet-491	109	30	correlated	correlate	VERB
admet-491	109	31	with	with	ADP
admet-491	109	32	log	log	PROPN
admet-491	109	33	po	po	PROPN
admet-491	109	34	/	/	SYM
admet-491	109	35	w	w	NOUN
admet-491	109	36	without	without	ADP
admet-491	109	37	the	the	DET
admet-491	109	38	additional	additional	ADJ
admet-491	109	39	need	need	NOUN
admet-491	109	40	of	of	ADP
admet-491	109	41	molecular	molecular	ADJ
admet-491	109	42	descriptors	descriptor	NOUN
admet-491	109	43	.	.	PUNCT
admet-491	110	1	thus	thus	ADV
admet-491	110	2	,	,	PUNCT
admet-491	110	3	a	a	DET
admet-491	110	4	high	high	ADJ
admet-491	110	5	-	-	PUNCT
admet-491	110	6	throughput	throughput	NOUN
admet-491	110	7	pressure	pressure	NOUN
admet-491	110	8	-	-	PUNCT
admet-491	110	9	assisted	assist	VERB
admet-491	110	10	meekc	meekc	ADJ
admet-491	110	11	methodology	methodology	NOUN
admet-491	110	12	with	with	ADP
admet-491	110	13	reversed	reverse	VERB
admet-491	110	14	polarity	polarity	NOUN
admet-491	110	15	for	for	ADP
admet-491	110	16	log	log	PROPN
admet-491	110	17	po	po	PROPN
admet-491	110	18	/	/	SYM
admet-491	110	19	w	w	NOUN
admet-491	110	20	determination	determination	NOUN
admet-491	110	21	of	of	ADP
admet-491	110	22	acidic	acidic	ADJ
admet-491	110	23	compounds	compound	NOUN
admet-491	110	24	(	(	PUNCT
admet-491	110	25	pka	pka	X
admet-491	110	26	>	>	X
admet-491	110	27	3.5	3.5	NUM
admet-491	110	28	)	)	PUNCT
admet-491	110	29	has	have	AUX
admet-491	110	30	been	be	AUX
admet-491	110	31	proposed	propose	VERB
admet-491	110	32	and	and	CCONJ
admet-491	110	33	validated	validated	ADJ
admet-491	110	34	(	(	PUNCT
admet-491	110	35	internally	internally	ADV
admet-491	110	36	and	and	CCONJ
admet-491	110	37	externally	externally	ADV
admet-491	110	38	)	)	PUNCT
admet-491	110	39	,	,	PUNCT
admet-491	110	40	using	use	VERB
admet-491	110	41	a	a	DET
admet-491	110	42	conventional	conventional	ADJ
admet-491	110	43	ce	ce	NOUN
admet-491	110	44	instrument	instrument	NOUN
admet-491	110	45	with	with	ADP
admet-491	110	46	uv	uv	NOUN
admet-491	110	47	detection	detection	NOUN
admet-491	110	48	and	and	CCONJ
admet-491	110	49	uncoated	uncoated	ADJ
admet-491	110	50	fused	fuse	VERB
admet-491	110	51	silica	silica	NOUN
admet-491	110	52	capillaries	capillary	NOUN
admet-491	110	53	.	.	PUNCT
admet-491	111	1	3	3	NUM
admet-491	111	2	-	-	PUNCT
admet-491	111	3	methylbenzoic	methylbenzoic	ADJ
admet-491	111	4	acid	acid	NOUN
admet-491	111	5	,	,	PUNCT
admet-491	111	6	phenobarbital	phenobarbital	ADJ
admet-491	111	7	,	,	PUNCT
admet-491	111	8	barbital	barbital	NOUN
admet-491	111	9	,	,	PUNCT
admet-491	111	10	and	and	CCONJ
admet-491	111	11	thiouracil	thiouracil	NOUN
admet-491	111	12	are	be	AUX
admet-491	111	13	proposed	propose	VERB
admet-491	111	14	as	as	ADP
admet-491	111	15	calibration	calibration	NOUN
admet-491	111	16	standards	standard	NOUN
admet-491	111	17	,	,	PUNCT
admet-491	111	18	allowing	allow	VERB
admet-491	111	19	the	the	DET
admet-491	111	20	measurement	measurement	NOUN
admet-491	111	21	of	of	ADP
admet-491	111	22	log	log	PROPN
admet-491	111	23	po	po	PROPN
admet-491	111	24	/	/	SYM
admet-491	111	25	w	w	NOUN
admet-491	111	26	values	value	NOUN
admet-491	111	27	in	in	ADP
admet-491	111	28	the	the	DET
admet-491	111	29	range	range	NOUN
admet-491	111	30	between	between	ADP
admet-491	111	31	-1.54	-1.54	NOUN
admet-491	111	32	and	and	CCONJ
admet-491	111	33	4.75	4.75	NUM
admet-491	111	34	with	with	ADP
admet-491	111	35	a	a	DET
admet-491	111	36	prediction	prediction	NOUN
admet-491	111	37	accuracy	accuracy	NOUN
admet-491	111	38	of	of	ADP
admet-491	111	39	±0.4	±0.4	PROPN
admet-491	111	40	.	.	PUNCT
admet-491	112	1	acknowledgements	acknowledgement	NOUN
admet-491	112	2	:	:	PUNCT
admet-491	112	3	this	this	DET
admet-491	112	4	work	work	NOUN
admet-491	112	5	is	be	AUX
admet-491	112	6	supported	support	VERB
admet-491	112	7	by	by	ADP
admet-491	112	8	the	the	DET
admet-491	112	9	ministry	ministry	PROPN
admet-491	112	10	of	of	ADP
admet-491	112	11	economy	economy	NOUN
admet-491	112	12	and	and	CCONJ
admet-491	112	13	competitiveness	competitiveness	NOUN
admet-491	112	14	of	of	ADP
admet-491	112	15	spain	spain	PROPN
admet-491	112	16	(	(	PUNCT
admet-491	112	17	project	project	NOUN
admet-491	112	18	ctq2014	ctq2014	NOUN
admet-491	112	19	-	-	PUNCT
admet-491	112	20	56253	56253	NUM
admet-491	112	21	-	-	PUNCT
admet-491	112	22	p	p	NOUN
admet-491	112	23	)	)	PUNCT
admet-491	112	24	.	.	PUNCT
admet-491	113	1	prof	prof	PROPN
admet-491	113	2	.	.	PUNCT
admet-491	114	1	paola	paola	PROPN
admet-491	114	2	gramatica	gramatica	PROPN
admet-491	114	3	is	be	AUX
admet-491	114	4	acknowledged	acknowledge	VERB
admet-491	114	5	for	for	ADP
admet-491	114	6	the	the	DET
admet-491	114	7	free	free	ADJ
admet-491	114	8	license	license	NOUN
admet-491	114	9	of	of	ADP
admet-491	114	10	qsarins	qsarin	NOUN
admet-491	114	11	software	software	NOUN
admet-491	114	12	[	[	X
admet-491	114	13	25	25	NUM
admet-491	114	14	]	]	PUNCT
admet-491	114	15	.	.	PUNCT
admet-491	115	1	references	reference	NOUN
admet-491	115	2	[	[	X
admet-491	115	3	1	1	NUM
admet-491	115	4	]	]	X
admet-491	115	5	c.g	c.g	PROPN
admet-491	115	6	.	.	PROPN
admet-491	115	7	wermuth	wermuth	PROPN
admet-491	115	8	,	,	PUNCT
admet-491	115	9	c.r	c.r	PROPN
admet-491	115	10	.	.	PROPN
admet-491	115	11	ganellin	ganellin	PROPN
admet-491	115	12	,	,	PUNCT
admet-491	115	13	p.	p.	PROPN
admet-491	115	14	lindberg	lindberg	PROPN
admet-491	115	15	,	,	PUNCT
admet-491	115	16	l.	l.	PROPN
admet-491	115	17	a.	a.	NOUN
admet-491	115	18	mitscher	mitscher	PROPN
admet-491	115	19	,	,	PUNCT
admet-491	115	20	glossary	glossary	NOUN
admet-491	115	21	of	of	ADP
admet-491	115	22	terms	term	NOUN
admet-491	115	23	used	use	VERB
admet-491	115	24	in	in	ADP
admet-491	115	25	computational	computational	ADJ
admet-491	115	26	drug	drug	NOUN
admet-491	115	27	design	design	NOUN
admet-491	115	28	,	,	PUNCT
admet-491	115	29	pure	pure	ADJ
admet-491	115	30	appl	appl	NOUN
admet-491	115	31	.	.	PUNCT
admet-491	116	1	chem	chem	PROPN
admet-491	116	2	.	.	PUNCT
admet-491	117	1	70	70	NUM
admet-491	117	2	(	(	PUNCT
admet-491	117	3	1998	1998	NUM
admet-491	117	4	)	)	PUNCT
admet-491	117	5	1129–1143	1129–1143	NUM
admet-491	117	6	.	.	PUNCT
admet-491	118	1	doi:10.1351	doi:10.1351	NOUN
admet-491	118	2	/	/	SYM
admet-491	118	3	pac197951081725	pac197951081725	NOUN
admet-491	118	4	.	.	PUNCT
admet-491	119	1	[	[	X
admet-491	119	2	2	2	X
admet-491	119	3	]	]	X
admet-491	119	4	j.a	j.a	PROPN
admet-491	119	5	.	.	PROPN
admet-491	119	6	arnott	arnott	PROPN
admet-491	119	7	,	,	PUNCT
admet-491	119	8	s.l	s.l	PROPN
admet-491	119	9	.	.	PROPN
admet-491	119	10	planey	planey	PROPN
admet-491	119	11	,	,	PUNCT
admet-491	119	12	the	the	DET
admet-491	119	13	influence	influence	NOUN
admet-491	119	14	of	of	ADP
admet-491	119	15	lipophilicity	lipophilicity	NOUN
admet-491	119	16	in	in	ADP
admet-491	119	17	drug	drug	NOUN
admet-491	119	18	discovery	discovery	NOUN
admet-491	119	19	and	and	CCONJ
admet-491	119	20	design	design	NOUN
admet-491	119	21	,	,	PUNCT
admet-491	119	22	expert	expert	NOUN
admet-491	119	23	opin	opin	NOUN
admet-491	119	24	.	.	PUNCT
admet-491	119	25	drug	drug	NOUN
admet-491	119	26	discov	discov	NOUN
admet-491	119	27	.	.	PUNCT
admet-491	120	1	7	7	NUM
admet-491	120	2	(	(	PUNCT
admet-491	120	3	2012	2012	NUM
admet-491	120	4	)	)	PUNCT
admet-491	121	1	863–875	863–875	NUM
admet-491	121	2	.	.	PUNCT
admet-491	122	1	doi:10.1517/17460441.2012.714363	doi:10.1517/17460441.2012.714363	VERB
admet-491	122	2	.	.	PUNCT
admet-491	123	1	[	[	X
admet-491	123	2	3	3	NUM
admet-491	123	3	]	]	X
admet-491	123	4	oecd	oecd	PROPN
admet-491	123	5	,	,	PUNCT
admet-491	123	6	test	test	NOUN
admet-491	123	7	no	no	NOUN
admet-491	123	8	.	.	PUNCT
admet-491	124	1	107	107	NUM
admet-491	124	2	:	:	PUNCT
admet-491	124	3	partition	partition	NOUN
admet-491	124	4	coefficient	coefficient	NOUN
admet-491	124	5	(	(	PUNCT
admet-491	124	6	n	n	CCONJ
admet-491	124	7	-	-	PUNCT
admet-491	124	8	octanol	octanol	NOUN
admet-491	124	9	/	/	SYM
admet-491	124	10	water	water	NOUN
admet-491	124	11	):	):	PUNCT
admet-491	124	12	shake	shake	VERB
admet-491	124	13	flask	flask	NOUN
admet-491	124	14	method	method	NOUN
admet-491	124	15	,	,	PUNCT
admet-491	124	16	oecd	oecd	PROPN
admet-491	124	17	publishing	publishing	NOUN
admet-491	124	18	,	,	PUNCT
admet-491	124	19	1995	1995	NUM
admet-491	124	20	.	.	PUNCT
admet-491	125	1	[	[	X
admet-491	125	2	4	4	NUM
admet-491	125	3	]	]	X
admet-491	125	4	oecd	oecd	PROPN
admet-491	125	5	,	,	PUNCT
admet-491	125	6	test	test	NOUN
admet-491	125	7	no	no	NOUN
admet-491	125	8	.	.	PROPN
admet-491	125	9	117	117	NUM
admet-491	125	10	:	:	PUNCT
admet-491	125	11	partition	partition	NOUN
admet-491	125	12	coefficient	coefficient	NOUN
admet-491	125	13	(	(	PUNCT
admet-491	125	14	n	n	CCONJ
admet-491	125	15	-	-	PUNCT
admet-491	125	16	octanol	octanol	NOUN
admet-491	125	17	/	/	SYM
admet-491	125	18	water	water	NOUN
admet-491	125	19	)	)	PUNCT
admet-491	125	20	,	,	PUNCT
admet-491	125	21	hplc	hplc	NOUN
admet-491	125	22	method	method	NOUN
admet-491	125	23	,	,	PUNCT
admet-491	125	24	oecd	oecd	PROPN
admet-491	125	25	publishing	publishing	NOUN
admet-491	125	26	,	,	PUNCT
admet-491	125	27	2004	2004	NUM
admet-491	125	28	.	.	PUNCT
admet-491	126	1	[	[	X
admet-491	126	2	5	5	NUM
admet-491	126	3	]	]	X
admet-491	126	4	echa	echa	NOUN
admet-491	126	5	,	,	PUNCT
admet-491	126	6	guidance	guidance	NOUN
admet-491	126	7	on	on	ADP
admet-491	126	8	information	information	NOUN
admet-491	126	9	requirements	requirement	NOUN
admet-491	126	10	and	and	CCONJ
admet-491	126	11	chemical	chemical	NOUN
admet-491	126	12	safety	safety	NOUN
admet-491	126	13	assessment	assessment	NOUN
admet-491	126	14	.	.	PUNCT
admet-491	127	1	chapter	chapter	NOUN
admet-491	127	2	r.7a	r.7a	PROPN
admet-491	127	3	:	:	PUNCT
admet-491	127	4	endpoint	endpoint	VERB
admet-491	127	5	specific	specific	ADJ
admet-491	127	6	guidance	guidance	NOUN
admet-491	127	7	:	:	PUNCT
admet-491	127	8	2016	2016	NUM
admet-491	127	9	.	.	PUNCT
admet-491	128	1	doi:10.2823/2611	doi:10.2823/2611	NOUN
admet-491	128	2	.	.	PUNCT
admet-491	129	1	[	[	X
admet-491	129	2	6	6	NUM
admet-491	129	3	]	]	PUNCT
admet-491	129	4	a.	a.	NOUN
admet-491	129	5	avdeef	avdeef	PROPN
admet-491	129	6	,	,	PUNCT
admet-491	129	7	ph	ph	ADJ
admet-491	129	8	-	-	ADJ
admet-491	129	9	metric	metric	ADJ
admet-491	129	10	log	log	NOUN
admet-491	129	11	p.	p.	NOUN
admet-491	129	12	part	part	NOUN
admet-491	129	13	i.	i.	PROPN
admet-491	129	14	difference	difference	NOUN
admet-491	129	15	plots	plot	NOUN
admet-491	129	16	for	for	ADP
admet-491	129	17	determining	determine	VERB
admet-491	129	18	ion	ion	NOUN
admet-491	129	19	-	-	PUNCT
admet-491	129	20	pair	pair	NOUN
admet-491	129	21	octanol	octanol	NOUN
admet-491	129	22	-	-	PUNCT
admet-491	129	23	water	water	NOUN
admet-491	129	24	partition	partition	NOUN
admet-491	129	25	coefficients	coefficient	NOUN
admet-491	129	26	of	of	ADP
admet-491	129	27	multiprotic	multiprotic	ADJ
admet-491	129	28	substances	substance	NOUN
admet-491	129	29	,	,	PUNCT
admet-491	129	30	quant	quant	NOUN
admet-491	129	31	.	.	PUNCT
admet-491	129	32	struct	struct	NOUN
admet-491	129	33	.	.	PUNCT
admet-491	130	1	relationships	relationship	NOUN
admet-491	130	2	.	.	PUNCT
admet-491	131	1	11	11	NUM
admet-491	131	2	(	(	PUNCT
admet-491	131	3	1992	1992	NUM
admet-491	131	4	)	)	PUNCT
admet-491	132	1	510–517	510–517	NUM
admet-491	132	2	.	.	PUNCT
admet-491	133	1	doi:10.1002	doi:10.1002	NOUN
admet-491	133	2	/	/	SYM
admet-491	133	3	qsar.2660110408	qsar.2660110408	PROPN
admet-491	133	4	.	.	PUNCT
admet-491	134	1	[	[	X
admet-491	134	2	7	7	NUM
admet-491	134	3	]	]	PUNCT
admet-491	134	4	a.	a.	NOUN
admet-491	134	5	avdeef	avdeef	PROPN
admet-491	134	6	,	,	PUNCT
admet-491	134	7	ph	ph	ADJ
admet-491	134	8	-	-	ADJ
admet-491	134	9	metric	metric	ADJ
admet-491	134	10	log	log	NOUN
admet-491	134	11	p.	p.	PROPN
admet-491	134	12	ii	ii	PROPN
admet-491	134	13	:	:	PUNCT
admet-491	134	14	refinement	refinement	NOUN
admet-491	134	15	of	of	ADP
admet-491	134	16	partition	partition	NOUN
admet-491	134	17	coefficients	coefficient	NOUN
admet-491	134	18	and	and	CCONJ
admet-491	134	19	ionization	ionization	NOUN
admet-491	134	20	constants	constant	NOUN
admet-491	134	21	of	of	ADP
admet-491	134	22	multiprotic	multiprotic	ADJ
admet-491	134	23	substances	substance	NOUN
admet-491	134	24	,	,	PUNCT
admet-491	134	25	j.	j.	PROPN
admet-491	134	26	pharm	pharm	PROPN
admet-491	134	27	.	.	PUNCT
admet-491	135	1	sci	sci	PROPN
admet-491	135	2	.	.	PROPN
admet-491	136	1	82	82	NUM
admet-491	136	2	(	(	PUNCT
admet-491	136	3	1993	1993	NUM
admet-491	136	4	)	)	PUNCT
admet-491	136	5	183–190	183–190	NUM
admet-491	136	6	.	.	PUNCT
admet-491	137	1	doi:10.1002	doi:10.1002	NOUN
admet-491	137	2	/	/	SYM
admet-491	137	3	jps.2600820214	jps.2600820214	NUM
admet-491	137	4	.	.	PUNCT
admet-491	138	1	[	[	X
admet-491	138	2	8	8	NUM
admet-491	138	3	]	]	PUNCT
admet-491	138	4	k.	k.	PROPN
admet-491	138	5	takács	takács	PROPN
admet-491	138	6	-	-	PUNCT
admet-491	138	7	novák	novák	PROPN
admet-491	138	8	,	,	PUNCT
admet-491	138	9	a.	a.	NOUN
admet-491	138	10	avdeef	avdeef	PROPN
admet-491	138	11	,	,	PUNCT
admet-491	138	12	interlaboratory	interlaboratory	ADJ
admet-491	138	13	study	study	NOUN
admet-491	138	14	of	of	ADP
admet-491	138	15	log	log	NOUN
admet-491	138	16	p	p	NOUN
admet-491	138	17	determination	determination	NOUN
admet-491	138	18	by	by	ADP
admet-491	138	19	shake	shake	NOUN
admet-491	138	20	-	-	PUNCT
admet-491	138	21	flask	flask	NOUN
admet-491	138	22	and	and	CCONJ
admet-491	138	23	potentiometric	potentiometric	ADJ
admet-491	138	24	methods	method	NOUN
admet-491	138	25	,	,	PUNCT
admet-491	138	26	j.	j.	PROPN
admet-491	138	27	pharm	pharm	PROPN
admet-491	138	28	.	.	PUNCT
admet-491	138	29	biomed	biome	VERB
admet-491	138	30	.	.	PUNCT
admet-491	139	1	anal	anal	ADJ
admet-491	139	2	.	.	PUNCT
admet-491	140	1	14	14	NUM
admet-491	140	2	(	(	PUNCT
admet-491	140	3	1996	1996	NUM
admet-491	140	4	)	)	PUNCT
admet-491	140	5	1405–1413	1405–1413	NUM
admet-491	140	6	.	.	PUNCT
admet-491	141	1	doi:10.1016/07317085(96)01773	doi:10.1016/07317085(96)01773	PROPN
admet-491	141	2	-	-	PUNCT
admet-491	141	3	6	6	PROPN
admet-491	141	4	.	.	PUNCT
admet-491	142	1	[	[	X
admet-491	142	2	9	9	NUM
admet-491	142	3	]	]	PUNCT
admet-491	142	4	k.	k.	NOUN
admet-491	142	5	valkó	valkó	PROPN
admet-491	142	6	,	,	PUNCT
admet-491	142	7	physicochemical	physicochemical	ADJ
admet-491	142	8	and	and	CCONJ
admet-491	142	9	biomimetic	biomimetic	ADJ
admet-491	142	10	properties	property	NOUN
admet-491	142	11	in	in	ADP
admet-491	142	12	drug	drug	NOUN
admet-491	142	13	discovery	discovery	NOUN
admet-491	142	14	,	,	PUNCT
admet-491	142	15	wiley	wiley	PROPN
admet-491	142	16	,	,	PUNCT
admet-491	142	17	hoboken	hoboken	PROPN
admet-491	142	18	,	,	PUNCT
admet-491	142	19	nj	nj	PROPN
admet-491	142	20	,	,	PUNCT
admet-491	142	21	usa	usa	PROPN
admet-491	142	22	,	,	PUNCT
admet-491	142	23	2014	2014	NUM
admet-491	142	24	.	.	PUNCT
admet-491	143	1	[	[	X
admet-491	143	2	10	10	NUM
admet-491	143	3	]	]	X
admet-491	143	4	j.m	j.m	PROPN
admet-491	143	5	.	.	PROPN
admet-491	143	6	pallicer	pallicer	NOUN
admet-491	143	7	,	,	PUNCT
admet-491	143	8	s.	s.	PROPN
admet-491	143	9	pous	pous	ADJ
admet-491	143	10	-	-	PUNCT
admet-491	143	11	torres	torre	NOUN
admet-491	143	12	,	,	PUNCT
admet-491	143	13	j.	j.	PROPN
admet-491	143	14	sales	sales	PROPN
admet-491	143	15	,	,	PUNCT
admet-491	143	16	m.	m.	NOUN
admet-491	143	17	rosés	rosés	PROPN
admet-491	143	18	,	,	PUNCT
admet-491	143	19	c.	c.	PROPN
admet-491	143	20	ràfols	ràfols	PROPN
admet-491	143	21	,	,	PUNCT
admet-491	143	22	e.	e.	PROPN
admet-491	143	23	bosch	bosch	PROPN
admet-491	143	24	,	,	PUNCT
admet-491	143	25	determination	determination	NOUN
admet-491	143	26	of	of	ADP
admet-491	143	27	the	the	DET
admet-491	143	28	hydrophobicity	hydrophobicity	NOUN
admet-491	143	29	of	of	ADP
admet-491	143	30	organic	organic	ADJ
admet-491	143	31	compounds	compound	NOUN
admet-491	143	32	measured	measure	VERB
admet-491	143	33	as	as	ADP
admet-491	143	34	log	log	NOUN
admet-491	143	35	po	po	PROPN
admet-491	143	36	/	/	SYM
admet-491	143	37	w	w	NOUN
admet-491	143	38	through	through	ADP
admet-491	143	39	a	a	DET
admet-491	143	40	new	new	ADJ
admet-491	143	41	chromatographic	chromatographic	ADJ
admet-491	143	42	method	method	NOUN
admet-491	143	43	,	,	PUNCT
admet-491	143	44	j.	j.	PROPN
admet-491	143	45	chromatogr	chromatogr	PROPN
admet-491	143	46	.	.	PUNCT
admet-491	144	1	a.	a.	NOUN
admet-491	144	2	1217	1217	NUM
admet-491	144	3	(	(	PUNCT
admet-491	144	4	2010	2010	NUM
admet-491	144	5	)	)	PUNCT
admet-491	144	6	3026–3037	3026–3037	NUM
admet-491	144	7	.	.	PUNCT
admet-491	145	1	doi:10.1016	doi:10.1016	PROPN
admet-491	145	2	/	/	SYM
admet-491	145	3	j.chroma.2010.02.051	j.chroma.2010.02.051	PROPN
admet-491	145	4	.	.	PUNCT
admet-491	146	1	[	[	X
admet-491	146	2	11	11	NUM
admet-491	146	3	]	]	X
admet-491	146	4	j.m	j.m	PROPN
admet-491	146	5	.	.	PROPN
admet-491	146	6	pallicer	pallicer	PROPN
admet-491	146	7	,	,	PUNCT
admet-491	146	8	r.	r.	PROPN
admet-491	146	9	pascual	pascual	PROPN
admet-491	146	10	,	,	PUNCT
admet-491	146	11	a.	a.	NOUN
admet-491	146	12	port	port	NOUN
admet-491	146	13	,	,	PUNCT
admet-491	146	14	m.	m.	NOUN
admet-491	146	15	rosés	rosés	PROPN
admet-491	146	16	,	,	PUNCT
admet-491	146	17	c.	c.	PROPN
admet-491	146	18	ràfols	ràfols	PROPN
admet-491	146	19	,	,	PUNCT
admet-491	146	20	e.	e.	PROPN
admet-491	146	21	bosch	bosch	PROPN
admet-491	146	22	,	,	PUNCT
admet-491	146	23	the	the	DET
admet-491	146	24	contribution	contribution	NOUN
admet-491	146	25	of	of	ADP
admet-491	146	26	the	the	DET
admet-491	146	27	hydrogen	hydrogen	NOUN
admet-491	146	28	bond	bond	NOUN
admet-491	146	29	acidity	acidity	NOUN
admet-491	146	30	on	on	ADP
admet-491	146	31	the	the	DET
admet-491	146	32	lipophilicity	lipophilicity	NOUN
admet-491	146	33	of	of	ADP
admet-491	146	34	drugs	drug	NOUN
admet-491	146	35	estimated	estimate	VERB
admet-491	146	36	from	from	ADP
admet-491	146	37	chromatographic	chromatographic	ADJ
admet-491	146	38	measurements	measurement	NOUN
admet-491	146	39	,	,	PUNCT
admet-491	146	40	eur	eur	PROPN
admet-491	146	41	.	.	PUNCT
admet-491	146	42	j.	j.	PROPN
admet-491	146	43	pharm	pharm	PROPN
admet-491	146	44	.	.	PUNCT
admet-491	147	1	sci	sci	PROPN
admet-491	147	2	.	.	PROPN
admet-491	148	1	48	48	NUM
admet-491	148	2	(	(	PUNCT
admet-491	148	3	2013	2013	NUM
admet-491	148	4	)	)	PUNCT
admet-491	148	5	484–493	484–493	NUM
admet-491	148	6	.	.	PUNCT
admet-491	149	1	doi:10.1016	doi:10.1016	PROPN
admet-491	149	2	/	/	SYM
admet-491	149	3	j.ejps.2012.12.008	j.ejps.2012.12.008	PROPN
admet-491	149	4	.	.	PUNCT
admet-491	150	1	[	[	X
admet-491	150	2	12	12	NUM
admet-491	150	3	]	]	PUNCT
admet-491	150	4	x.	x.	NOUN
admet-491	150	5	subirats	subirat	NOUN
admet-491	150	6	,	,	PUNCT
admet-491	150	7	m.	m.	NOUN
admet-491	150	8	rosés	rosés	PROPN
admet-491	150	9	,	,	PUNCT
admet-491	150	10	e.	e.	PROPN
admet-491	150	11	bosch	bosch	PROPN
admet-491	150	12	,	,	PUNCT
admet-491	150	13	high	high	ADJ
admet-491	150	14	-	-	PUNCT
admet-491	150	15	throughput	throughput	NOUN
admet-491	150	16	log	log	NOUN
admet-491	150	17	po	po	NOUN
admet-491	150	18	/	/	SYM
admet-491	150	19	w	w	NOUN
admet-491	150	20	determination	determination	NOUN
admet-491	150	21	from	from	ADP
admet-491	150	22	uhplc	uhplc	PROPN
admet-491	150	23	measurements	measurement	NOUN
admet-491	150	24	:	:	PUNCT
admet-491	150	25	revisiting	revisit	VERB
admet-491	150	26	the	the	DET
admet-491	150	27	chromatographic	chromatographic	ADJ
admet-491	150	28	hydrophobicity	hydrophobicity	NOUN
admet-491	150	29	index	index	NOUN
admet-491	150	30	,	,	PUNCT
admet-491	150	31	j.	j.	PROPN
admet-491	150	32	pharm	pharm	PROPN
admet-491	150	33	.	.	PUNCT
admet-491	150	34	biomed	biome	VERB
admet-491	150	35	.	.	PUNCT
admet-491	151	1	anal	anal	ADJ
admet-491	151	2	.	.	PUNCT
admet-491	152	1	127	127	NUM
admet-491	152	2	(	(	PUNCT
admet-491	152	3	2015	2015	NUM
admet-491	152	4	)	)	PUNCT
admet-491	152	5	26–31	26–31	PROPN
admet-491	152	6	.	.	PUNCT
admet-491	152	7	doi:10.1016	doi:10.1016	PROPN
admet-491	152	8	/	/	SYM
admet-491	152	9	j.jpba.2015.12.015	j.jpba.2015.12.015	PROPN
admet-491	152	10	.	.	PUNCT
admet-491	153	1	[	[	X
admet-491	153	2	13	13	NUM
admet-491	153	3	]	]	X
admet-491	153	4	y.	y.	PROPN
admet-491	153	5	ishihama	ishihama	PROPN
admet-491	153	6	,	,	PUNCT
admet-491	153	7	y.	y.	PROPN
admet-491	153	8	oda	oda	PROPN
admet-491	153	9	,	,	PUNCT
admet-491	153	10	k.	k.	PROPN
admet-491	153	11	uchikawa	uchikawa	PROPN
admet-491	153	12	,	,	PUNCT
admet-491	153	13	n.	n.	PROPN
admet-491	153	14	asakawa	asakawa	PROPN
admet-491	153	15	,	,	PUNCT
admet-491	153	16	evaluation	evaluation	NOUN
admet-491	153	17	of	of	ADP
admet-491	153	18	solute	solute	NOUN
admet-491	153	19	hydrophobicity	hydrophobicity	NOUN
admet-491	153	20	by	by	ADP
admet-491	153	21	microemulsion	microemulsion	PROPN
admet-491	153	22	electrokinetic	electrokinetic	ADJ
admet-491	153	23	chromatography	chromatography	NOUN
admet-491	153	24	,	,	PUNCT
admet-491	153	25	anal	anal	NOUN
admet-491	153	26	.	.	PUNCT
admet-491	153	27	chem	chem	PROPN
admet-491	153	28	.	.	PUNCT
admet-491	154	1	67	67	NUM
admet-491	154	2	(	(	PUNCT
admet-491	154	3	1995	1995	NUM
admet-491	154	4	)	)	PUNCT
admet-491	154	5	1588–1595	1588–1595	NUM
admet-491	154	6	.	.	PUNCT
admet-491	155	1	doi:10.1002	doi:10.1002	NOUN
admet-491	155	2	/	/	SYM
admet-491	155	3	elps.200410141	elps.200410141	PROPN
admet-491	155	4	.	.	PROPN
admet-491	155	5	admet	admet	PROPN
admet-491	155	6	&	&	CCONJ
admet-491	155	7	dmpk	dmpk	PROPN
admet-491	155	8	6(2	6(2	NUM
admet-491	155	9	)	)	PUNCT
admet-491	155	10	(	(	PUNCT
admet-491	155	11	2018	2018	NUM
admet-491	155	12	)	)	PUNCT
admet-491	155	13	153	153	NUM
admet-491	155	14	-	-	SYM
admet-491	155	15	161	161	NUM
admet-491	155	16	lipophylicity	lipophylicity	NOUN
admet-491	155	17	determination	determination	NOUN
admet-491	155	18	of	of	ADP
admet-491	155	19	acidic	acidic	ADJ
admet-491	155	20	compounds	compound	NOUN
admet-491	155	21	by	by	ADP
admet-491	155	22	meekc	meekc	ADJ
admet-491	155	23	doi	doi	PROPN
admet-491	155	24	:	:	PUNCT
admet-491	155	25	10.5599	10.5599	NUM
admet-491	155	26	/	/	SYM
admet-491	155	27	admet.491	admet.491	PROPN
admet-491	155	28	161	161	NUM
admet-491	155	29	[	[	X
admet-491	155	30	14	14	NUM
admet-491	155	31	]	]	PUNCT
admet-491	155	32	x.	x.	NOUN
admet-491	155	33	subirats	subirat	NOUN
admet-491	155	34	,	,	PUNCT
admet-491	155	35	h.-p	h.-p	PROPN
admet-491	155	36	.	.	PUNCT
admet-491	156	1	yuan	yuan	NOUN
admet-491	156	2	,	,	PUNCT
admet-491	156	3	v.	v.	PROPN
admet-491	156	4	chaves	chave	NOUN
admet-491	156	5	,	,	PUNCT
admet-491	156	6	n.	n.	PROPN
admet-491	156	7	marzal	marzal	PROPN
admet-491	156	8	,	,	PUNCT
admet-491	156	9	m.	m.	NOUN
admet-491	156	10	rosés	rosés	PROPN
admet-491	156	11	,	,	PUNCT
admet-491	156	12	microemulsion	microemulsion	NOUN
admet-491	156	13	electrokinetic	electrokinetic	ADJ
admet-491	156	14	chromatography	chromatography	NOUN
admet-491	156	15	as	as	ADP
admet-491	156	16	a	a	DET
admet-491	156	17	suitable	suitable	ADJ
admet-491	156	18	tool	tool	NOUN
admet-491	156	19	for	for	ADP
admet-491	156	20	lipophilicity	lipophilicity	NOUN
admet-491	156	21	determination	determination	NOUN
admet-491	156	22	of	of	ADP
admet-491	156	23	acidic	acidic	ADJ
admet-491	156	24	,	,	PUNCT
admet-491	156	25	neutral	neutral	ADJ
admet-491	156	26	,	,	PUNCT
admet-491	156	27	and	and	CCONJ
admet-491	156	28	basic	basic	ADJ
admet-491	156	29	compounds	compound	NOUN
admet-491	156	30	,	,	PUNCT
admet-491	156	31	electrophoresis	electrophoresis	NOUN
admet-491	156	32	.	.	PUNCT
admet-491	157	1	37	37	NUM
admet-491	157	2	(	(	PUNCT
admet-491	157	3	2016	2016	NUM
admet-491	157	4	)	)	PUNCT
admet-491	157	5	2010–2016	2010–2016	NUM
admet-491	157	6	.	.	PUNCT
admet-491	158	1	doi:10.1002	doi:10.1002	NOUN
admet-491	158	2	/	/	SYM
admet-491	158	3	elps.201600080	elps.201600080	PROPN
admet-491	158	4	.	.	PUNCT
admet-491	159	1	[	[	X
admet-491	159	2	15	15	NUM
admet-491	159	3	]	]	X
admet-491	159	4	y.	y.	PROPN
admet-491	159	5	henchoz	henchoz	PROPN
admet-491	159	6	,	,	PUNCT
admet-491	159	7	s.	s.	PROPN
admet-491	159	8	romand	romand	PROPN
admet-491	159	9	,	,	PUNCT
admet-491	159	10	j.	j.	PROPN
admet-491	159	11	schappler	schappler	PROPN
admet-491	159	12	,	,	PUNCT
admet-491	159	13	s.	s.	PROPN
admet-491	159	14	rudaz	rudaz	PROPN
admet-491	159	15	,	,	PUNCT
admet-491	159	16	j.l	j.l	PROPN
admet-491	159	17	.	.	PROPN
admet-491	159	18	veuthey	veuthey	PROPN
admet-491	159	19	,	,	PUNCT
admet-491	159	20	p.a	p.a	PROPN
admet-491	159	21	.	.	PROPN
admet-491	159	22	carrupt	carrupt	PROPN
admet-491	159	23	,	,	PUNCT
admet-491	159	24	high	high	ADJ
admet-491	159	25	-	-	PUNCT
admet-491	159	26	throughput	throughput	NOUN
admet-491	159	27	log	log	NOUN
admet-491	159	28	p	p	NOUN
admet-491	159	29	determination	determination	NOUN
admet-491	159	30	by	by	ADP
admet-491	159	31	meekc	meekc	NOUN
admet-491	159	32	coupled	couple	VERB
admet-491	159	33	with	with	ADP
admet-491	159	34	uv	uv	NOUN
admet-491	159	35	and	and	CCONJ
admet-491	159	36	ms	ms	NOUN
admet-491	159	37	detections	detection	NOUN
admet-491	159	38	,	,	PUNCT
admet-491	159	39	electrophoresis	electrophoresis	NOUN
admet-491	159	40	.	.	NOUN
admet-491	160	1	31	31	NUM
admet-491	160	2	(	(	PUNCT
admet-491	160	3	2010	2010	NUM
admet-491	160	4	)	)	PUNCT
admet-491	161	1	952–964	952–964	NUM
admet-491	161	2	.	.	PUNCT
admet-491	162	1	doi:10.1002	doi:10.1002	NOUN
admet-491	162	2	/	/	SYM
admet-491	162	3	elps.200900540	elps.200900540	PROPN
admet-491	162	4	.	.	PUNCT
admet-491	163	1	[	[	X
admet-491	163	2	16	16	NUM
admet-491	163	3	]	]	X
admet-491	163	4	s.k	s.k	PROPN
admet-491	163	5	.	.	PROPN
admet-491	163	6	poole	poole	PROPN
admet-491	163	7	,	,	PUNCT
admet-491	163	8	d.	d.	PROPN
admet-491	163	9	durham	durham	PROPN
admet-491	163	10	,	,	PUNCT
admet-491	163	11	c.	c.	PROPN
admet-491	163	12	kibbey	kibbey	PROPN
admet-491	163	13	,	,	PUNCT
admet-491	163	14	rapid	rapid	ADJ
admet-491	163	15	method	method	NOUN
admet-491	163	16	for	for	ADP
admet-491	163	17	estimating	estimate	VERB
admet-491	163	18	the	the	DET
admet-491	163	19	octanol	octanol	NOUN
admet-491	163	20	-	-	PUNCT
admet-491	163	21	water	water	NOUN
admet-491	163	22	partition	partition	NOUN
admet-491	163	23	coefficient	coefficient	NOUN
admet-491	163	24	(	(	PUNCT
admet-491	163	25	log	log	NOUN
admet-491	163	26	pow	pow	NOUN
admet-491	163	27	)	)	PUNCT
admet-491	163	28	by	by	ADP
admet-491	163	29	microemulsion	microemulsion	PROPN
admet-491	163	30	electrokinetic	electrokinetic	ADJ
admet-491	163	31	chromatography	chromatography	NOUN
admet-491	163	32	,	,	PUNCT
admet-491	163	33	j.	j.	PROPN
admet-491	163	34	chromatogr	chromatogr	PROPN
admet-491	163	35	.	.	PUNCT
admet-491	164	1	b	b	X
admet-491	164	2	biomed	biome	VERB
admet-491	164	3	.	.	PUNCT
admet-491	165	1	sci	sci	PROPN
admet-491	165	2	.	.	PROPN
admet-491	165	3	appl	appl	PROPN
admet-491	165	4	.	.	PROPN
admet-491	166	1	745	745	NUM
admet-491	166	2	(	(	PUNCT
admet-491	166	3	2000	2000	NUM
admet-491	166	4	)	)	PUNCT
admet-491	167	1	117–126	117–126	NUM
admet-491	167	2	.	.	PUNCT
admet-491	168	1	doi:10.1016	doi:10.1016	PROPN
admet-491	168	2	/	/	SYM
admet-491	168	3	s0378	s0378	PROPN
admet-491	168	4	-	-	PUNCT
admet-491	168	5	4347(00)00072	4347(00)00072	NOUN
admet-491	168	6	-	-	PUNCT
admet-491	168	7	4	4	NUM
admet-491	168	8	.	.	PUNCT
admet-491	169	1	[	[	X
admet-491	169	2	17	17	NUM
admet-491	169	3	]	]	X
admet-491	169	4	m.-l	m.-l	PROPN
admet-491	169	5	.	.	PUNCT
admet-491	170	1	riekkola	riekkola	PROPN
admet-491	170	2	,	,	PUNCT
admet-491	170	3	j.å	j.å	PROPN
admet-491	170	4	.	.	PROPN
admet-491	170	5	jönsson	jönsson	PROPN
admet-491	170	6	,	,	PUNCT
admet-491	170	7	terminology	terminology	NOUN
admet-491	170	8	for	for	ADP
admet-491	170	9	analytical	analytical	ADJ
admet-491	170	10	capillary	capillary	ADJ
admet-491	170	11	electromigration	electromigration	NOUN
admet-491	170	12	techniques	technique	NOUN
admet-491	170	13	,	,	PUNCT
admet-491	170	14	int	int	NOUN
admet-491	170	15	.	.	PUNCT
admet-491	171	1	union	union	PROPN
admet-491	171	2	pure	pure	ADJ
admet-491	171	3	appl	appl	PROPN
admet-491	171	4	.	.	PUNCT
admet-491	172	1	chem	chem	PROPN
admet-491	172	2	.	.	PUNCT
admet-491	173	1	76	76	NUM
admet-491	173	2	(	(	PUNCT
admet-491	173	3	2001	2001	NUM
admet-491	173	4	)	)	PUNCT
admet-491	173	5	1–8	1–8	X
admet-491	173	6	.	.	PUNCT
admet-491	173	7	doi:10.1351	doi:10.1351	NOUN
admet-491	173	8	/	/	SYM
admet-491	173	9	pac200476020443	pac200476020443	NOUN
admet-491	173	10	.	.	PUNCT
admet-491	174	1	[	[	X
admet-491	174	2	18	18	NUM
admet-491	174	3	]	]	PUNCT
admet-491	174	4	p.	p.	NOUN
admet-491	174	5	gramatica	gramatica	PROPN
admet-491	174	6	,	,	PUNCT
admet-491	174	7	principles	principle	NOUN
admet-491	174	8	of	of	ADP
admet-491	174	9	qsar	qsar	NOUN
admet-491	174	10	models	model	NOUN
admet-491	174	11	validation	validation	NOUN
admet-491	174	12	:	:	PUNCT
admet-491	174	13	internal	internal	ADJ
admet-491	174	14	and	and	CCONJ
admet-491	174	15	external	external	ADJ
admet-491	174	16	,	,	PUNCT
admet-491	174	17	qsar	qsar	NOUN
admet-491	174	18	comb	comb	NOUN
admet-491	174	19	.	.	PUNCT
admet-491	175	1	sci	sci	PROPN
admet-491	175	2	.	.	PROPN
admet-491	175	3	26	26	NUM
admet-491	175	4	(	(	PUNCT
admet-491	175	5	2007	2007	NUM
admet-491	175	6	)	)	PUNCT
admet-491	175	7	694–701	694–701	NUM
admet-491	175	8	.	.	PUNCT
admet-491	175	9	doi:10.1002	doi:10.1002	NOUN
admet-491	175	10	/	/	SYM
admet-491	175	11	qsar.200610151	qsar.200610151	PROPN
admet-491	175	12	.	.	PUNCT
admet-491	176	1	[	[	X
admet-491	176	2	19	19	NUM
admet-491	176	3	]	]	PUNCT
admet-491	176	4	a.	a.	NOUN
admet-491	176	5	golbraikh	golbraikh	NOUN
admet-491	176	6	,	,	PUNCT
admet-491	176	7	a.	a.	NOUN
admet-491	176	8	tropsha	tropsha	PROPN
admet-491	176	9	,	,	PUNCT
admet-491	176	10	beware	beware	NOUN
admet-491	176	11	of	of	ADP
admet-491	176	12	q2	q2	NOUN
admet-491	176	13	!	!	PROPN
admet-491	176	14	,	,	PUNCT
admet-491	176	15	j.	j.	PROPN
admet-491	176	16	mol	mol	PROPN
admet-491	176	17	.	.	PROPN
admet-491	176	18	graph	graph	PROPN
admet-491	176	19	.	.	PUNCT
admet-491	176	20	model	model	NOUN
admet-491	176	21	.	.	PROPN
admet-491	177	1	20	20	NUM
admet-491	177	2	(	(	PUNCT
admet-491	177	3	2002	2002	NUM
admet-491	177	4	)	)	PUNCT
admet-491	178	1	269–276	269–276	NUM
admet-491	178	2	.	.	PUNCT
admet-491	178	3	doi:10.1016	doi:10.1016	PROPN
admet-491	178	4	/	/	SYM
admet-491	178	5	s1093	s1093	PROPN
admet-491	178	6	-	-	PUNCT
admet-491	178	7	3263(01)00123	3263(01)00123	NUM
admet-491	178	8	-	-	PUNCT
admet-491	178	9	1	1	NUM
admet-491	178	10	.	.	PUNCT
admet-491	179	1	[	[	X
admet-491	179	2	20	20	NUM
admet-491	179	3	]	]	X
admet-491	179	4	n.	n.	PROPN
admet-491	179	5	chirico	chirico	PROPN
admet-491	179	6	,	,	PUNCT
admet-491	179	7	p.	p.	NOUN
admet-491	179	8	gramatica	gramatica	PROPN
admet-491	179	9	,	,	PUNCT
admet-491	179	10	real	real	ADJ
admet-491	179	11	external	external	ADJ
admet-491	179	12	predictivity	predictivity	NOUN
admet-491	179	13	of	of	ADP
admet-491	179	14	qsar	qsar	NOUN
admet-491	179	15	models	model	NOUN
admet-491	179	16	:	:	PUNCT
admet-491	179	17	how	how	SCONJ
admet-491	179	18	to	to	PART
admet-491	179	19	evaluate	evaluate	VERB
admet-491	179	20	it	it	PRON
admet-491	179	21	?	?	PUNCT
admet-491	180	1	comparison	comparison	NOUN
admet-491	180	2	of	of	ADP
admet-491	180	3	different	different	ADJ
admet-491	180	4	validation	validation	NOUN
admet-491	180	5	criteria	criterion	NOUN
admet-491	180	6	and	and	CCONJ
admet-491	180	7	proposal	proposal	NOUN
admet-491	180	8	of	of	ADP
admet-491	180	9	using	use	VERB
admet-491	180	10	the	the	DET
admet-491	180	11	concordance	concordance	NOUN
admet-491	180	12	correlation	correlation	NOUN
admet-491	180	13	coefficient	coefficient	NOUN
admet-491	180	14	,	,	PUNCT
admet-491	180	15	j.	j.	PROPN
admet-491	180	16	chem	chem	PROPN
admet-491	180	17	.	.	PUNCT
admet-491	181	1	inf	inf	PROPN
admet-491	181	2	.	.	PROPN
admet-491	181	3	model	model	PROPN
admet-491	181	4	.	.	PUNCT
admet-491	182	1	51	51	NUM
admet-491	182	2	(	(	PUNCT
admet-491	182	3	2011	2011	NUM
admet-491	182	4	)	)	PUNCT
admet-491	182	5	2320–2335	2320–2335	NUM
admet-491	182	6	.	.	PUNCT
admet-491	183	1	doi:10.1021	doi:10.1021	PROPN
admet-491	183	2	/	/	SYM
admet-491	183	3	ci200211n	ci200211n	X
admet-491	183	4	.	.	PUNCT
admet-491	184	1	[	[	X
admet-491	184	2	21	21	NUM
admet-491	184	3	]	]	X
admet-491	184	4	bio	bio	NOUN
admet-491	184	5	-	-	NOUN
admet-491	184	6	loom	loom	NOUN
admet-491	184	7	.	.	PUNCT
admet-491	185	1	biobyte	biobyte	PROPN
admet-491	185	2	corp	corp	PROPN
admet-491	185	3	.	.	PROPN
admet-491	185	4	claremont	claremont	PROPN
admet-491	185	5	,	,	PUNCT
admet-491	185	6	ca	ca	PROPN
admet-491	185	7	,	,	PUNCT
admet-491	185	8	usa	usa	PROPN
admet-491	185	9	.	.	PROPN
admet-491	185	10	www.biobyte.com	www.biobyte.com	PROPN
admet-491	185	11	.	.	PUNCT
admet-491	186	1	[	[	X
admet-491	186	2	22	22	NUM
admet-491	186	3	]	]	X
admet-491	186	4	acd	acd	PROPN
admet-491	186	5	/	/	SYM
admet-491	186	6	labs	lab	NOUN
admet-491	186	7	.	.	PUNCT
admet-491	187	1	advanced	advanced	ADJ
admet-491	187	2	chemistry	chemistry	NOUN
admet-491	187	3	development	development	PROPN
admet-491	187	4	,	,	PUNCT
admet-491	187	5	inc	inc	PROPN
admet-491	187	6	.	.	PROPN
admet-491	187	7	toronto	toronto	PROPN
admet-491	187	8	,	,	PUNCT
admet-491	187	9	on	on	ADP
admet-491	187	10	,	,	PUNCT
admet-491	187	11	canada	canada	PROPN
admet-491	187	12	.	.	PUNCT
admet-491	188	1	www.acdlabs.com	www.acdlabs.com	X
admet-491	188	2	.	.	PUNCT
admet-491	189	1	[	[	X
admet-491	189	2	23	23	NUM
admet-491	189	3	]	]	X
admet-491	189	4	chemspider	chemspider	NOUN
admet-491	189	5	.	.	PUNCT
admet-491	190	1	royal	royal	ADJ
admet-491	190	2	society	society	NOUN
admet-491	190	3	of	of	ADP
admet-491	190	4	chemistry	chemistry	NOUN
admet-491	190	5	,	,	PUNCT
admet-491	190	6	uk	uk	PROPN
admet-491	190	7	.	.	PROPN
admet-491	190	8	www.chemspider.com	www.chemspider.com	PROPN
admet-491	190	9	.	.	PUNCT
admet-491	191	1	[	[	X
admet-491	191	2	24	24	NUM
admet-491	191	3	]	]	SYM
admet-491	191	4	epa	epa	PROPN
admet-491	191	5	,	,	PUNCT
admet-491	191	6	product	product	NOUN
admet-491	191	7	properties	property	NOUN
admet-491	191	8	test	test	NOUN
admet-491	191	9	guidelines	guideline	NOUN
admet-491	191	10	.	.	PUNCT
admet-491	192	1	oppts	oppts	PROPN
admet-491	192	2	830.7550	830.7550	NUM
admet-491	192	3	.	.	PUNCT
admet-491	193	1	partition	partition	NOUN
admet-491	193	2	coefficient	coefficient	NOUN
admet-491	193	3	(	(	PUNCT
admet-491	193	4	n	n	CCONJ
admet-491	193	5	-	-	PUNCT
admet-491	193	6	octanol	octanol	NOUN
admet-491	193	7	/	/	SYM
admet-491	193	8	water	water	NOUN
admet-491	193	9	)	)	PUNCT
admet-491	193	10	,	,	PUNCT
admet-491	193	11	shake	shake	VERB
admet-491	193	12	flask	flask	NOUN
admet-491	193	13	method	method	NOUN
admet-491	193	14	,	,	PUNCT
admet-491	193	15	u.s	u.s	PROPN
admet-491	193	16	.	.	PROPN
admet-491	193	17	environmental	environmental	PROPN
admet-491	193	18	protection	protection	PROPN
admet-491	193	19	agency	agency	PROPN
admet-491	193	20	,	,	PUNCT
admet-491	193	21	prevention	prevention	NOUN
admet-491	193	22	,	,	PUNCT
admet-491	193	23	pesticides	pesticide	NOUN
admet-491	193	24	and	and	CCONJ
admet-491	193	25	toxic	toxic	ADJ
admet-491	193	26	substances	substance	NOUN
admet-491	193	27	,	,	PUNCT
admet-491	193	28	united	united	PROPN
admet-491	193	29	states	states	PROPN
admet-491	193	30	,	,	PUNCT
admet-491	193	31	1996	1996	NUM
admet-491	193	32	.	.	PUNCT
admet-491	194	1	[	[	X
admet-491	194	2	25	25	NUM
admet-491	194	3	]	]	X
admet-491	194	4	p.	p.	NOUN
admet-491	194	5	gramatica	gramatica	PROPN
admet-491	194	6	,	,	PUNCT
admet-491	194	7	n.	n.	PROPN
admet-491	194	8	chirico	chirico	PROPN
admet-491	194	9	,	,	PUNCT
admet-491	194	10	e.	e.	PROPN
admet-491	194	11	papa	papa	PROPN
admet-491	194	12	,	,	PUNCT
admet-491	194	13	s.	s.	PROPN
admet-491	194	14	cassani	cassani	PROPN
admet-491	194	15	,	,	PUNCT
admet-491	194	16	s.	s.	PROPN
admet-491	194	17	kovarich	kovarich	PROPN
admet-491	194	18	,	,	PUNCT
admet-491	194	19	qsarins	qsarin	VERB
admet-491	194	20	:	:	PUNCT
admet-491	194	21	a	a	DET
admet-491	194	22	new	new	ADJ
admet-491	194	23	software	software	NOUN
admet-491	194	24	for	for	ADP
admet-491	194	25	the	the	DET
admet-491	194	26	development	development	NOUN
admet-491	194	27	,	,	PUNCT
admet-491	194	28	analysis	analysis	NOUN
admet-491	194	29	,	,	PUNCT
admet-491	194	30	and	and	CCONJ
admet-491	194	31	validation	validation	NOUN
admet-491	194	32	of	of	ADP
admet-491	194	33	qsar	qsar	NOUN
admet-491	194	34	mlr	mlr	NOUN
admet-491	194	35	models	model	NOUN
admet-491	194	36	,	,	PUNCT
admet-491	194	37	j.	j.	PROPN
admet-491	194	38	comput	comput	PROPN
admet-491	194	39	.	.	PUNCT
admet-491	195	1	chem	chem	NOUN
admet-491	195	2	.	.	PUNCT
admet-491	196	1	34	34	NUM
admet-491	196	2	(	(	PUNCT
admet-491	196	3	2013	2013	NUM
admet-491	196	4	)	)	PUNCT
admet-491	196	5	2121	2121	NUM
admet-491	196	6	–	–	PUNCT
admet-491	196	7	2132	2132	NUM
admet-491	196	8	.	.	PUNCT
admet-491	197	1	doi:10.1002	doi:10.1002	NOUN
admet-491	197	2	/	/	SYM
admet-491	197	3	jcc.23361	jcc.23361	PROPN
admet-491	197	4	.	.	PUNCT
admet-491	198	1	©	©	NOUN
admet-491	198	2	2018	2018	NUM
admet-491	198	3	by	by	ADP
admet-491	198	4	the	the	DET
admet-491	198	5	authors	author	NOUN
admet-491	198	6	;	;	PUNCT
admet-491	199	1	licensee	licensee	PROPN
admet-491	199	2	iapc	iapc	PROPN
admet-491	199	3	,	,	PUNCT
admet-491	199	4	zagreb	zagreb	PROPN
admet-491	199	5	,	,	PUNCT
admet-491	199	6	croatia	croatia	PROPN
admet-491	199	7	.	.	PUNCT
admet-491	200	1	this	this	DET
admet-491	200	2	article	article	NOUN
admet-491	200	3	is	be	AUX
admet-491	200	4	an	an	DET
admet-491	200	5	open	open	ADJ
admet-491	200	6	-	-	PUNCT
admet-491	200	7	access	access	NOUN
admet-491	200	8	article	article	NOUN
admet-491	200	9	distributed	distribute	VERB
admet-491	200	10	under	under	ADP
admet-491	200	11	the	the	DET
admet-491	200	12	terms	term	NOUN
admet-491	200	13	and	and	CCONJ
admet-491	200	14	conditions	condition	NOUN
admet-491	200	15	of	of	ADP
admet-491	200	16	the	the	DET
admet-491	200	17	creative	creative	ADJ
admet-491	200	18	commons	common	NOUN
admet-491	200	19	attribution	attribution	NOUN
admet-491	200	20	license	license	NOUN
admet-491	200	21	(	(	PUNCT
admet-491	200	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-491	200	23	)	)	PUNCT
admet-491	200	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN