id	sid	tid	token	lemma	pos
admet-514	1	1	subcellular	subcellular	ADJ
admet-514	1	2	localization	localization	NOUN
admet-514	1	3	of	of	ADP
admet-514	1	4	several	several	ADJ
admet-514	1	5	structurally	structurally	ADV
admet-514	1	6	different	different	ADJ
admet-514	1	7	tyrosine	tyrosine	NOUN
admet-514	1	8	kinase	kinase	PROPN
admet-514	1	9	inhibitors	inhibitor	NOUN
admet-514	1	10	doi	doi	NOUN
admet-514	1	11	:	:	PUNCT
admet-514	1	12	10.5599	10.5599	NUM
admet-514	1	13	/	/	SYM
admet-514	1	14	admet.514	admet.514	PROPN
admet-514	1	15	258	258	NUM
admet-514	1	16	admet	admet	NOUN
admet-514	1	17	&	&	CCONJ
admet-514	1	18	dmpk	dmpk	PROPN
admet-514	1	19	6(3	6(3	PROPN
admet-514	1	20	)	)	PUNCT
admet-514	1	21	(	(	PUNCT
admet-514	1	22	2018	2018	NUM
admet-514	1	23	)	)	PUNCT
admet-514	1	24	258	258	NUM
admet-514	1	25	-	-	SYM
admet-514	1	26	266	266	NUM
admet-514	1	27	;	;	PUNCT
admet-514	1	28	doi	doi	NOUN
admet-514	1	29	:	:	PUNCT
admet-514	1	30	http://dx.doi.org/10.5599/admet.514	http://dx.doi.org/10.5599/admet.514	X
admet-514	1	31	open	open	ADJ
admet-514	1	32	access	access	NOUN
admet-514	1	33	:	:	PUNCT
admet-514	1	34	issn	issn	PROPN
admet-514	1	35	:	:	PUNCT
admet-514	1	36	1848	1848	NUM
admet-514	1	37	-	-	SYM
admet-514	1	38	7718	7718	NUM
admet-514	1	39	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-514	1	40	original	original	ADJ
admet-514	1	41	scientific	scientific	ADJ
admet-514	1	42	article	article	NOUN
admet-514	1	43	subcellular	subcellular	ADJ
admet-514	1	44	localization	localization	NOUN
admet-514	1	45	of	of	ADP
admet-514	1	46	several	several	ADJ
admet-514	1	47	structurally	structurally	ADV
admet-514	1	48	different	different	ADJ
admet-514	1	49	tyrosine	tyrosine	NOUN
admet-514	1	50	kinase	kinase	PROPN
admet-514	1	51	inhibitors	inhibitors	PROPN
admet-514	1	52	richard	richard	PROPN
admet-514	1	53	j.	j.	PROPN
admet-514	1	54	honeywell	honeywell	PROPN
admet-514	1	55	*	*	PROPN
admet-514	1	56	,	,	PUNCT
admet-514	1	57	sarina	sarina	PROPN
admet-514	1	58	m.	m.	PROPN
admet-514	1	59	hitzerd	hitzerd	PROPN
admet-514	1	60	,	,	PUNCT
admet-514	1	61	g.a.m	g.a.m	PROPN
admet-514	1	62	.	.	PUNCT
admet-514	1	63	kathmann	kathmann	PROPN
admet-514	1	64	,	,	PUNCT
admet-514	1	65	godefridus	godefridus	PROPN
admet-514	1	66	j.	j.	PROPN
admet-514	1	67	peters	peters	PROPN
admet-514	1	68	dept	dept	PROPN
admet-514	1	69	of	of	ADP
admet-514	1	70	medical	medical	ADJ
admet-514	1	71	oncology	oncology	NOUN
admet-514	1	72	,	,	PUNCT
admet-514	1	73	vu	vu	PROPN
admet-514	1	74	university	university	PROPN
admet-514	1	75	medical	medical	ADJ
admet-514	1	76	center	center	NOUN
admet-514	1	77	,	,	PUNCT
admet-514	1	78	po	po	PROPN
admet-514	1	79	box	box	PROPN
admet-514	1	80	7057	7057	NUM
admet-514	1	81	,	,	PUNCT
admet-514	1	82	1007	1007	NUM
admet-514	1	83	mb	mb	ADP
admet-514	1	84	amsterdam	amsterdam	PROPN
admet-514	1	85	,	,	PUNCT
admet-514	2	1	the	the	DET
admet-514	2	2	netherlands	netherlands	PROPN
admet-514	2	3	*	*	PUNCT
admet-514	2	4	corresponding	correspond	VERB
admet-514	2	5	author	author	NOUN
admet-514	2	6	:	:	PUNCT
admet-514	2	7	e	e	NOUN
admet-514	2	8	-	-	NOUN
admet-514	2	9	mail	mail	NOUN
admet-514	2	10	:	:	PUNCT
admet-514	2	11	r.honeywell@vumc.nl	r.honeywell@vumc.nl	NOUN
admet-514	2	12	.	.	PUNCT
admet-514	2	13	received	receive	VERB
admet-514	2	14	:	:	PUNCT
admet-514	2	15	march	march	PROPN
admet-514	2	16	06	06	NUM
admet-514	2	17	,	,	PUNCT
admet-514	2	18	2018	2018	NUM
admet-514	2	19	;	;	PUNCT
admet-514	2	20	revised	revise	VERB
admet-514	2	21	:	:	PUNCT
admet-514	2	22	may	may	AUX
admet-514	2	23	21	21	NUM
admet-514	2	24	,	,	PUNCT
admet-514	2	25	2018	2018	NUM
admet-514	2	26	;	;	PUNCT
admet-514	2	27	available	available	ADJ
admet-514	2	28	online	online	NOUN
admet-514	2	29	:	:	PUNCT
admet-514	2	30	july	july	PROPN
admet-514	2	31	16	16	NUM
admet-514	2	32	,	,	PUNCT
admet-514	2	33	2018	2018	NUM
admet-514	2	34	abstract	abstract	ADJ
admet-514	2	35	protein	protein	NOUN
admet-514	2	36	tyrosine	tyrosine	NOUN
admet-514	2	37	kinases	kinase	NOUN
admet-514	2	38	form	form	VERB
admet-514	2	39	an	an	DET
admet-514	2	40	important	important	ADJ
admet-514	2	41	target	target	NOUN
admet-514	2	42	for	for	ADP
admet-514	2	43	a	a	DET
admet-514	2	44	new	new	ADJ
admet-514	2	45	class	class	NOUN
admet-514	2	46	of	of	ADP
admet-514	2	47	anticancer	anticancer	NOUN
admet-514	2	48	drugs	drug	NOUN
admet-514	2	49	,	,	PUNCT
admet-514	2	50	the	the	DET
admet-514	2	51	tyrosine	tyrosine	NOUN
admet-514	2	52	kinase	kinase	PROPN
admet-514	2	53	inhibitors	inhibitor	NOUN
admet-514	2	54	(	(	PUNCT
admet-514	2	55	tkis	tkis	NOUN
admet-514	2	56	)	)	PUNCT
admet-514	2	57	.	.	PUNCT
admet-514	3	1	recently	recently	ADV
admet-514	3	2	we	we	PRON
admet-514	3	3	demonstrated	demonstrate	VERB
admet-514	3	4	that	that	SCONJ
admet-514	3	5	sunitinib	sunitinib	NOUN
admet-514	3	6	,	,	PUNCT
admet-514	3	7	an	an	DET
admet-514	3	8	inhibitor	inhibitor	NOUN
admet-514	3	9	of	of	ADP
admet-514	3	10	the	the	DET
admet-514	3	11	membrane	membrane	NOUN
admet-514	3	12	-	-	PUNCT
admet-514	3	13	associated	associate	VERB
admet-514	3	14	vascular	vascular	ADJ
admet-514	3	15	endothelial	endothelial	NOUN
admet-514	3	16	growth	growth	NOUN
admet-514	3	17	factor	factor	NOUN
admet-514	3	18	receptor	receptor	NOUN
admet-514	3	19	(	(	PUNCT
admet-514	3	20	vegfr	vegfr	NOUN
admet-514	3	21	)	)	PUNCT
admet-514	3	22	,	,	PUNCT
admet-514	3	23	is	be	AUX
admet-514	3	24	trapped	trap	VERB
admet-514	3	25	in	in	ADP
admet-514	3	26	lysosomes	lysosome	NOUN
admet-514	3	27	which	which	PRON
admet-514	3	28	isolates	isolate	VERB
admet-514	3	29	the	the	DET
admet-514	3	30	drug	drug	NOUN
admet-514	3	31	from	from	ADP
admet-514	3	32	its	its	PRON
admet-514	3	33	intended	intended	ADJ
admet-514	3	34	target	target	NOUN
admet-514	3	35	.	.	PUNCT
admet-514	4	1	therefore	therefore	ADV
admet-514	4	2	we	we	PRON
admet-514	4	3	investigated	investigate	VERB
admet-514	4	4	whether	whether	SCONJ
admet-514	4	5	this	this	PRON
admet-514	4	6	also	also	ADV
admet-514	4	7	holds	hold	VERB
admet-514	4	8	for	for	ADP
admet-514	4	9	other	other	ADJ
admet-514	4	10	tkis	tkis	NOUN
admet-514	4	11	,	,	PUNCT
admet-514	4	12	targeted	target	VERB
admet-514	4	13	against	against	ADP
admet-514	4	14	different	different	ADJ
admet-514	4	15	protein	protein	NOUN
admet-514	4	16	kinases	kinase	NOUN
admet-514	4	17	.	.	PUNCT
admet-514	5	1	for	for	ADP
admet-514	5	2	this	this	DET
admet-514	5	3	purpose	purpose	NOUN
admet-514	5	4	we	we	PRON
admet-514	5	5	used	use	VERB
admet-514	5	6	the	the	DET
admet-514	5	7	proteoextractr	proteoextractr	PROPN
admet-514	5	8	kit	kit	PROPN
admet-514	5	9	,	,	PUNCT
admet-514	5	10	which	which	PRON
admet-514	5	11	enables	enable	VERB
admet-514	5	12	a	a	DET
admet-514	5	13	subcellular	subcellular	ADJ
admet-514	5	14	extraction	extraction	NOUN
admet-514	5	15	separating	separate	VERB
admet-514	5	16	cellular	cellular	ADJ
admet-514	5	17	proteins	protein	NOUN
admet-514	5	18	into	into	ADP
admet-514	5	19	four	four	NUM
admet-514	5	20	distinct	distinct	ADJ
admet-514	5	21	fractions	fraction	NOUN
admet-514	5	22	covering	cover	VERB
admet-514	5	23	the	the	DET
admet-514	5	24	cytosol	cytosol	NOUN
admet-514	5	25	,	,	PUNCT
admet-514	5	26	membranes	membrane	NOUN
admet-514	5	27	and	and	CCONJ
admet-514	5	28	membrane	membrane	NOUN
admet-514	5	29	organelles	organelle	NOUN
admet-514	5	30	(	(	PUNCT
admet-514	5	31	including	include	VERB
admet-514	5	32	lysosomes	lysosome	NOUN
admet-514	5	33	)	)	PUNCT
admet-514	5	34	,	,	PUNCT
admet-514	5	35	nuclear	nuclear	ADJ
admet-514	5	36	proteins	protein	NOUN
admet-514	5	37	and	and	CCONJ
admet-514	5	38	the	the	DET
admet-514	5	39	cytoskeleton	cytoskeleton	NOUN
admet-514	5	40	.	.	PUNCT
admet-514	6	1	since	since	SCONJ
admet-514	6	2	tkis	tkis	PROPN
admet-514	6	3	are	be	AUX
admet-514	6	4	98	98	NUM
admet-514	6	5	-	-	SYM
admet-514	6	6	100	100	NUM
admet-514	6	7	%	%	NOUN
admet-514	6	8	protein	protein	NOUN
admet-514	6	9	bound	bind	VERB
admet-514	6	10	we	we	PRON
admet-514	6	11	used	use	VERB
admet-514	6	12	this	this	DET
admet-514	6	13	property	property	NOUN
admet-514	6	14	to	to	PART
admet-514	6	15	study	study	VERB
admet-514	6	16	their	their	PRON
admet-514	6	17	subcellular	subcellular	ADJ
admet-514	6	18	distribution	distribution	NOUN
admet-514	6	19	and	and	CCONJ
admet-514	6	20	used	use	VERB
admet-514	6	21	caco-2	caco-2	NUM
admet-514	6	22	cells	cell	NOUN
admet-514	6	23	as	as	ADP
admet-514	6	24	a	a	DET
admet-514	6	25	model	model	NOUN
admet-514	6	26	.	.	PUNCT
admet-514	7	1	as	as	SCONJ
admet-514	7	2	expected	expect	VERB
admet-514	7	3	after	after	SCONJ
admet-514	7	4	2	2	NUM
admet-514	7	5	hours	hour	NOUN
admet-514	7	6	exposure	exposure	NOUN
admet-514	7	7	sunitinib	sunitinib	NOUN
admet-514	7	8	was	be	AUX
admet-514	7	9	trapped	trap	VERB
admet-514	7	10	in	in	ADP
admet-514	7	11	cytosol	cytosol	NOUN
admet-514	7	12	(	(	PUNCT
admet-514	7	13	58	58	NUM
admet-514	7	14	%	%	NOUN
admet-514	7	15	)	)	PUNCT
admet-514	7	16	and	and	CCONJ
admet-514	7	17	organelles	organelle	NOUN
admet-514	7	18	(	(	PUNCT
admet-514	7	19	42	42	NUM
admet-514	7	20	%	%	NOUN
admet-514	7	21	including	include	VERB
admet-514	7	22	lysosomes	lysosome	NOUN
admet-514	7	23	)	)	PUNCT
admet-514	7	24	.	.	PUNCT
admet-514	8	1	crizotinib	crizotinib	PROPN
admet-514	8	2	,	,	PUNCT
admet-514	8	3	an	an	DET
admet-514	8	4	inhibitor	inhibitor	NOUN
admet-514	8	5	of	of	ADP
admet-514	8	6	alk	alk	NOUN
admet-514	8	7	-	-	PUNCT
admet-514	8	8	eml4	eml4	PROPN
admet-514	8	9	,	,	PUNCT
admet-514	8	10	showed	show	VERB
admet-514	8	11	a	a	DET
admet-514	8	12	similar	similar	ADJ
admet-514	8	13	distribution	distribution	NOUN
admet-514	8	14	.	.	PUNCT
admet-514	9	1	however	however	ADV
admet-514	9	2	,	,	PUNCT
admet-514	9	3	erlotinib	erlotinib	PROPN
admet-514	9	4	,	,	PUNCT
admet-514	9	5	an	an	DET
admet-514	9	6	inhibitor	inhibitor	NOUN
admet-514	9	7	of	of	ADP
admet-514	9	8	the	the	DET
admet-514	9	9	epidermal	epidermal	ADJ
admet-514	9	10	growth	growth	NOUN
admet-514	9	11	factor	factor	NOUN
admet-514	9	12	receptor	receptor	NOUN
admet-514	9	13	(	(	PUNCT
admet-514	9	14	egfr	egfr	X
admet-514	9	15	)	)	PUNCT
admet-514	9	16	showed	show	VERB
admet-514	9	17	a	a	DET
admet-514	9	18	very	very	ADV
admet-514	9	19	low	low	ADJ
admet-514	9	20	cellular	cellular	ADJ
admet-514	9	21	accumulation	accumulation	NOUN
admet-514	9	22	and	and	CCONJ
admet-514	9	23	was	be	AUX
admet-514	9	24	limited	limit	VERB
admet-514	9	25	to	to	ADP
admet-514	9	26	the	the	DET
admet-514	9	27	organelle	organelle	NOUN
admet-514	9	28	fraction	fraction	NOUN
admet-514	9	29	.	.	PUNCT
admet-514	10	1	in	in	ADP
admet-514	10	2	contrast	contrast	NOUN
admet-514	10	3	,	,	PUNCT
admet-514	10	4	the	the	DET
admet-514	10	5	other	other	ADJ
admet-514	10	6	egfr	egfr	ADJ
admet-514	10	7	inhibitor	inhibitor	NOUN
admet-514	10	8	,	,	PUNCT
admet-514	10	9	gefitinib	gefitinib	NOUN
admet-514	10	10	was	be	AUX
admet-514	10	11	predominantly	predominantly	ADV
admet-514	10	12	located	locate	VERB
admet-514	10	13	in	in	ADP
admet-514	10	14	the	the	DET
admet-514	10	15	cytosolic	cytosolic	NOUN
admet-514	10	16	(	(	PUNCT
admet-514	10	17	39	39	NUM
admet-514	10	18	%	%	NOUN
admet-514	10	19	)	)	PUNCT
admet-514	10	20	and	and	CCONJ
admet-514	10	21	membrane	membrane	NOUN
admet-514	10	22	fraction	fraction	NOUN
admet-514	10	23	(	(	PUNCT
admet-514	10	24	44	44	NUM
admet-514	10	25	%	%	NOUN
admet-514	10	26	)	)	PUNCT
admet-514	10	27	.	.	PUNCT
admet-514	11	1	sorafenib	sorafenib	PROPN
admet-514	11	2	,	,	PUNCT
admet-514	11	3	another	another	DET
admet-514	11	4	vegfr	vegfr	ADJ
admet-514	11	5	inhibitor	inhibitor	NOUN
admet-514	11	6	was	be	AUX
admet-514	11	7	predominantly	predominantly	ADV
admet-514	11	8	located	locate	VERB
admet-514	11	9	in	in	ADP
admet-514	11	10	the	the	DET
admet-514	11	11	organelle	organelle	NOUN
admet-514	11	12	fraction	fraction	NOUN
admet-514	11	13	(	(	PUNCT
admet-514	11	14	85	85	NUM
admet-514	11	15	%	%	NOUN
admet-514	11	16	)	)	PUNCT
admet-514	11	17	and	and	CCONJ
admet-514	11	18	cytosol	cytosol	NOUN
admet-514	11	19	(	(	PUNCT
admet-514	11	20	15	15	NUM
admet-514	11	21	%	%	NOUN
admet-514	11	22	)	)	PUNCT
admet-514	11	23	after	after	ADP
admet-514	11	24	2	2	NUM
admet-514	11	25	hours	hour	NOUN
admet-514	11	26	,	,	PUNCT
admet-514	11	27	while	while	SCONJ
admet-514	11	28	after	after	SCONJ
admet-514	11	29	24	24	NUM
admet-514	11	30	hours	hour	NOUN
admet-514	11	31	distribution	distribution	NOUN
admet-514	11	32	decreased	decrease	VERB
admet-514	11	33	(	(	PUNCT
admet-514	11	34	9.9	9.9	NUM
admet-514	11	35	fold	fold	NOUN
admet-514	11	36	)	)	PUNCT
admet-514	11	37	with	with	ADP
admet-514	11	38	a	a	DET
admet-514	11	39	slight	slight	ADJ
admet-514	11	40	shift	shift	NOUN
admet-514	11	41	.	.	PUNCT
admet-514	12	1	dasatinib	dasatinib	NOUN
admet-514	12	2	,	,	PUNCT
admet-514	12	3	an	an	DET
admet-514	12	4	inhibitor	inhibitor	NOUN
admet-514	12	5	of	of	ADP
admet-514	12	6	bcr	bcr	PROPN
admet-514	12	7	-	-	PROPN
admet-514	12	8	abl	abl	PROPN
admet-514	12	9	was	be	AUX
admet-514	12	10	located	locate	VERB
admet-514	12	11	only	only	ADV
admet-514	12	12	in	in	ADP
admet-514	12	13	the	the	DET
admet-514	12	14	cytosol	cytosol	NOUN
admet-514	12	15	(	(	PUNCT
admet-514	12	16	100	100	NUM
admet-514	12	17	%	%	NOUN
admet-514	12	18	)	)	PUNCT
admet-514	12	19	.	.	PUNCT
admet-514	13	1	in	in	ADP
admet-514	13	2	general	general	ADJ
admet-514	13	3	localization	localization	NOUN
admet-514	13	4	after	after	SCONJ
admet-514	13	5	24	24	NUM
admet-514	13	6	hours	hour	NOUN
admet-514	13	7	was	be	AUX
admet-514	13	8	comparable	comparable	ADJ
admet-514	13	9	,	,	PUNCT
admet-514	13	10	albeit	albeit	SCONJ
admet-514	13	11	several	several	ADJ
admet-514	13	12	small	small	ADJ
admet-514	13	13	changes	change	NOUN
admet-514	13	14	were	be	AUX
admet-514	13	15	seen	see	VERB
admet-514	13	16	.	.	PUNCT
admet-514	14	1	in	in	ADP
admet-514	14	2	conclusion	conclusion	NOUN
admet-514	14	3	protein	protein	NOUN
admet-514	14	4	fractionation	fractionation	NOUN
admet-514	14	5	with	with	ADP
admet-514	14	6	the	the	DET
admet-514	14	7	proteoextractr	proteoextractr	ADJ
admet-514	14	8	subcellular	subcellular	ADJ
admet-514	14	9	proteome	proteome	ADJ
admet-514	14	10	extraction	extraction	NOUN
admet-514	14	11	kit	kit	NOUN
admet-514	14	12	demonstrated	demonstrate	VERB
admet-514	14	13	large	large	ADJ
admet-514	14	14	differences	difference	NOUN
admet-514	14	15	in	in	ADP
admet-514	14	16	tki	tki	NOUN
admet-514	14	17	levels	level	NOUN
admet-514	14	18	in	in	ADP
admet-514	14	19	various	various	ADJ
admet-514	14	20	cellular	cellular	ADJ
admet-514	14	21	organelles	organelle	NOUN
admet-514	14	22	,	,	PUNCT
admet-514	14	23	with	with	ADP
admet-514	14	24	a	a	DET
admet-514	14	25	pattern	pattern	NOUN
admet-514	14	26	in	in	ADP
admet-514	14	27	agreement	agreement	NOUN
admet-514	14	28	with	with	ADP
admet-514	14	29	lysosomal	lysosomal	ADJ
admet-514	14	30	accumulation	accumulation	NOUN
admet-514	14	31	of	of	ADP
admet-514	14	32	sunitinib	sunitinib	NOUN
admet-514	14	33	.	.	PUNCT
admet-514	15	1	keywords	keyword	VERB
admet-514	15	2	tyrosine	tyrosine	PROPN
admet-514	15	3	kinase	kinase	PROPN
admet-514	15	4	inhibitors	inhibitor	NOUN
admet-514	15	5	;	;	PUNCT
admet-514	15	6	lysosomal	lysosomal	ADJ
admet-514	15	7	accumulation	accumulation	NOUN
admet-514	15	8	;	;	PUNCT
admet-514	15	9	subcellular	subcellular	ADJ
admet-514	15	10	distribution	distribution	NOUN
admet-514	15	11	;	;	PUNCT
admet-514	15	12	sunitinib	sunitinib	NOUN
admet-514	15	13	;	;	PUNCT
admet-514	15	14	erlotinib	erlotinib	NOUN
admet-514	15	15	;	;	PUNCT
admet-514	15	16	dasatinib	dasatinib	NOUN
admet-514	15	17	introduction	introduction	NOUN
admet-514	15	18	protein	protein	NOUN
admet-514	15	19	tyrosine	tyrosine	NOUN
admet-514	15	20	kinases	kinase	NOUN
admet-514	15	21	(	(	PUNCT
admet-514	15	22	ptks	ptks	NOUN
admet-514	15	23	)	)	PUNCT
admet-514	15	24	regulate	regulate	VERB
admet-514	15	25	important	important	ADJ
admet-514	15	26	signaling	signal	VERB
admet-514	15	27	processes	process	NOUN
admet-514	15	28	specific	specific	ADJ
admet-514	15	29	for	for	ADP
admet-514	15	30	the	the	DET
admet-514	15	31	cancer	cancer	NOUN
admet-514	15	32	cell	cell	NOUN
admet-514	16	1	[	[	X
admet-514	16	2	1	1	NUM
admet-514	16	3	]	]	PUNCT
admet-514	16	4	.	.	PUNCT
admet-514	17	1	because	because	SCONJ
admet-514	17	2	of	of	ADP
admet-514	17	3	this	this	DET
admet-514	17	4	important	important	ADJ
admet-514	17	5	role	role	NOUN
admet-514	17	6	a	a	DET
admet-514	17	7	new	new	ADJ
admet-514	17	8	class	class	NOUN
admet-514	17	9	of	of	ADP
admet-514	17	10	drugs	drug	NOUN
admet-514	17	11	,	,	PUNCT
admet-514	17	12	the	the	DET
admet-514	17	13	tyrosine	tyrosine	NOUN
admet-514	17	14	kinase	kinase	PROPN
admet-514	17	15	inhibitors	inhibitor	NOUN
admet-514	17	16	(	(	PUNCT
admet-514	17	17	tkis	tkis	NOUN
admet-514	17	18	)	)	PUNCT
admet-514	17	19	have	have	AUX
admet-514	17	20	been	be	AUX
admet-514	17	21	developed	develop	VERB
admet-514	17	22	[	[	PUNCT
admet-514	17	23	2,3	2,3	NUM
admet-514	17	24	]	]	PUNCT
admet-514	17	25	.	.	PUNCT
admet-514	18	1	the	the	DET
admet-514	18	2	targets	target	NOUN
admet-514	18	3	for	for	ADP
admet-514	18	4	these	these	DET
admet-514	18	5	drugs	drug	NOUN
admet-514	18	6	are	be	AUX
admet-514	18	7	receptors	receptor	NOUN
admet-514	18	8	located	locate	VERB
admet-514	18	9	either	either	CCONJ
admet-514	18	10	on	on	ADP
admet-514	18	11	or	or	CCONJ
admet-514	18	12	in	in	ADP
admet-514	18	13	the	the	DET
admet-514	18	14	membrane	membrane	NOUN
admet-514	18	15	or	or	CCONJ
admet-514	18	16	intracellularly	intracellularly	NOUN
admet-514	18	17	.	.	PUNCT
admet-514	19	1	this	this	PRON
admet-514	19	2	holds	hold	VERB
admet-514	19	3	both	both	PRON
admet-514	19	4	for	for	ADP
admet-514	19	5	tumor	tumor	NOUN
admet-514	19	6	cells	cell	NOUN
admet-514	19	7	and	and	CCONJ
admet-514	19	8	tumor	tumor	NOUN
admet-514	19	9	-	-	PUNCT
admet-514	19	10	associated	associate	VERB
admet-514	19	11	endothelial	endothelial	ADJ
admet-514	19	12	cells	cell	NOUN
admet-514	19	13	[	[	X
admet-514	19	14	4	4	NUM
admet-514	19	15	]	]	PUNCT
admet-514	19	16	.	.	PUNCT
admet-514	20	1	a	a	DET
admet-514	20	2	decreased	decrease	VERB
admet-514	20	3	uptake	uptake	ADJ
admet-514	20	4	or	or	CCONJ
admet-514	20	5	increased	increase	VERB
admet-514	20	6	efflux	efflux	NOUN
admet-514	20	7	may	may	AUX
admet-514	20	8	limit	limit	VERB
admet-514	20	9	the	the	DET
admet-514	20	10	cellular	cellular	ADJ
admet-514	20	11	drug	drug	NOUN
admet-514	20	12	accumulation	accumulation	NOUN
admet-514	20	13	,	,	PUNCT
admet-514	20	14	and	and	CCONJ
admet-514	20	15	the	the	DET
admet-514	20	16	efficacy	efficacy	NOUN
admet-514	20	17	of	of	ADP
admet-514	20	18	these	these	DET
admet-514	20	19	drugs	drug	NOUN
admet-514	20	20	[	[	X
admet-514	20	21	5	5	NUM
admet-514	20	22	]	]	PUNCT
admet-514	20	23	.	.	PUNCT
admet-514	21	1	moreover	moreover	ADV
admet-514	21	2	,	,	PUNCT
admet-514	21	3	inhibition	inhibition	NOUN
admet-514	21	4	may	may	AUX
admet-514	21	5	be	be	AUX
admet-514	21	6	reversible	reversible	ADJ
admet-514	21	7	or	or	CCONJ
admet-514	21	8	irreversible	irreversible	ADJ
admet-514	21	9	;	;	PUNCT
admet-514	21	10	especially	especially	ADV
admet-514	21	11	novel	novel	ADJ
admet-514	21	12	third	third	ADJ
admet-514	21	13	or	or	CCONJ
admet-514	21	14	fourth	fourth	ADJ
admet-514	21	15	generation	generation	NOUN
admet-514	21	16	tkis	tkis	PROPN
admet-514	21	17	display	display	NOUN
admet-514	21	18	irreversible	irreversible	ADJ
admet-514	21	19	enzyme	enzyme	NOUN
admet-514	21	20	inhibition	inhibition	NOUN
admet-514	21	21	[	[	X
admet-514	21	22	6	6	NUM
admet-514	21	23	]	]	PUNCT
admet-514	21	24	.	.	PUNCT
admet-514	22	1	recently	recently	ADV
admet-514	22	2	we	we	PRON
admet-514	22	3	demonstrated	demonstrate	VERB
admet-514	22	4	that	that	SCONJ
admet-514	22	5	sunitinib	sunitinib	NOUN
admet-514	22	6	,	,	PUNCT
admet-514	22	7	an	an	DET
admet-514	22	8	inhibitor	inhibitor	NOUN
admet-514	22	9	of	of	ADP
admet-514	22	10	the	the	DET
admet-514	22	11	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-514	22	12	mailto:r.honeywell@vumc.nl	mailto:r.honeywell@vumc.nl	PROPN
admet-514	22	13	admet	admet	PROPN
admet-514	22	14	&	&	CCONJ
admet-514	22	15	dmpk	dmpk	PROPN
admet-514	22	16	6(3	6(3	PROPN
admet-514	22	17	)	)	PUNCT
admet-514	22	18	(	(	PUNCT
admet-514	22	19	2018	2018	NUM
admet-514	22	20	)	)	PUNCT
admet-514	22	21	258	258	NUM
admet-514	22	22	-	-	PUNCT
admet-514	22	23	266	266	NUM
admet-514	22	24	subcellular	subcellular	ADJ
admet-514	22	25	localization	localization	NOUN
admet-514	22	26	of	of	ADP
admet-514	22	27	several	several	ADJ
admet-514	22	28	structurally	structurally	ADV
admet-514	22	29	different	different	ADJ
admet-514	22	30	tkis	tkis	PROPN
admet-514	22	31	doi	doi	NOUN
admet-514	22	32	:	:	PUNCT
admet-514	22	33	10.5599	10.5599	NUM
admet-514	22	34	/	/	SYM
admet-514	22	35	admet.514	admet.514	PROPN
admet-514	22	36	259	259	NUM
admet-514	22	37	vascular	vascular	ADJ
admet-514	22	38	endothelial	endothelial	ADJ
admet-514	22	39	growth	growth	NOUN
admet-514	22	40	factor	factor	NOUN
admet-514	22	41	receptor	receptor	NOUN
admet-514	22	42	(	(	PUNCT
admet-514	22	43	vegfr	vegfr	NOUN
admet-514	22	44	)	)	PUNCT
admet-514	22	45	accumulates	accumulate	VERB
admet-514	22	46	in	in	ADP
admet-514	22	47	lysosomes	lysosome	NOUN
admet-514	22	48	[	[	X
admet-514	22	49	7	7	NUM
admet-514	22	50	]	]	PUNCT
admet-514	22	51	,	,	PUNCT
admet-514	22	52	while	while	SCONJ
admet-514	22	53	preliminary	preliminary	ADJ
admet-514	22	54	experiments	experiment	NOUN
admet-514	22	55	demonstrated	demonstrate	VERB
admet-514	22	56	a	a	DET
admet-514	22	57	similar	similar	ADJ
admet-514	22	58	distribution	distribution	NOUN
admet-514	22	59	for	for	ADP
admet-514	22	60	crizotinib	crizotinib	NOUN
admet-514	22	61	,	,	PUNCT
admet-514	22	62	an	an	DET
admet-514	22	63	alk	alk	NOUN
admet-514	22	64	-	-	PUNCT
admet-514	22	65	eml4	eml4	PROPN
admet-514	22	66	and	and	CCONJ
admet-514	22	67	cmet	cmet	VERB
admet-514	22	68	inhibitor	inhibitor	NOUN
admet-514	23	1	[	[	X
admet-514	23	2	5	5	NUM
admet-514	23	3	]	]	PUNCT
admet-514	23	4	.	.	PUNCT
admet-514	24	1	in	in	ADP
admet-514	24	2	contrast	contrast	NOUN
admet-514	24	3	,	,	PUNCT
admet-514	24	4	erlotinib	erlotinib	VERB
admet-514	24	5	an	an	DET
admet-514	24	6	inhibitor	inhibitor	NOUN
admet-514	24	7	of	of	ADP
admet-514	24	8	the	the	DET
admet-514	24	9	epidermal	epidermal	ADJ
admet-514	24	10	growth	growth	NOUN
admet-514	24	11	factor	factor	NOUN
admet-514	24	12	receptor	receptor	NOUN
admet-514	24	13	(	(	PUNCT
admet-514	24	14	egfr	egfr	X
admet-514	24	15	)	)	PUNCT
admet-514	24	16	showed	show	VERB
admet-514	24	17	a	a	DET
admet-514	24	18	very	very	ADV
admet-514	24	19	low	low	ADJ
admet-514	24	20	cellular	cellular	ADJ
admet-514	24	21	uptake	uptake	NOUN
admet-514	24	22	limited	limit	VERB
admet-514	24	23	to	to	ADP
admet-514	24	24	the	the	DET
admet-514	24	25	membrane	membrane	NOUN
admet-514	24	26	[	[	X
admet-514	24	27	8	8	NUM
admet-514	24	28	]	]	PUNCT
admet-514	24	29	.	.	PUNCT
admet-514	25	1	therefore	therefore	ADV
admet-514	25	2	,	,	PUNCT
admet-514	25	3	we	we	PRON
admet-514	25	4	wondered	wonder	VERB
admet-514	25	5	whether	whether	SCONJ
admet-514	25	6	drug	drug	NOUN
admet-514	25	7	accumulation	accumulation	NOUN
admet-514	25	8	or	or	CCONJ
admet-514	25	9	drug	drug	NOUN
admet-514	25	10	distribution	distribution	NOUN
admet-514	25	11	would	would	AUX
admet-514	25	12	be	be	AUX
admet-514	25	13	related	relate	VERB
admet-514	25	14	to	to	ADP
admet-514	25	15	their	their	PRON
admet-514	25	16	efficacy	efficacy	NOUN
admet-514	25	17	.	.	PUNCT
admet-514	26	1	since	since	SCONJ
admet-514	26	2	tkis	tkis	NOUN
admet-514	26	3	are	be	AUX
admet-514	26	4	98	98	NUM
admet-514	26	5	-	-	SYM
admet-514	26	6	100	100	NUM
admet-514	26	7	%	%	NOUN
admet-514	26	8	plasma	plasma	NOUN
admet-514	26	9	protein	protein	NOUN
admet-514	26	10	bound	bind	VERB
admet-514	26	11	[	[	PUNCT
admet-514	26	12	9,10	9,10	X
admet-514	26	13	]	]	X
admet-514	26	14	we	we	PRON
admet-514	26	15	also	also	ADV
admet-514	26	16	wondered	wonder	VERB
admet-514	26	17	whether	whether	SCONJ
admet-514	26	18	this	this	PRON
admet-514	26	19	is	be	AUX
admet-514	26	20	reflected	reflect	VERB
admet-514	26	21	cellularly	cellularly	ADV
admet-514	26	22	and	and	CCONJ
admet-514	26	23	whether	whether	SCONJ
admet-514	26	24	this	this	PRON
admet-514	26	25	would	would	AUX
admet-514	26	26	affect	affect	VERB
admet-514	26	27	the	the	DET
admet-514	26	28	distribution	distribution	NOUN
admet-514	26	29	and	and	CCONJ
admet-514	26	30	accumulation	accumulation	NOUN
admet-514	26	31	of	of	ADP
admet-514	26	32	a	a	DET
admet-514	26	33	tki	tki	NOUN
admet-514	26	34	.	.	PROPN
admet-514	27	1	for	for	ADP
admet-514	27	2	this	this	DET
admet-514	27	3	purpose	purpose	NOUN
admet-514	27	4	,	,	PUNCT
admet-514	27	5	we	we	PRON
admet-514	27	6	used	use	VERB
admet-514	27	7	methodology	methodology	NOUN
admet-514	27	8	,	,	PUNCT
admet-514	27	9	which	which	PRON
admet-514	27	10	is	be	AUX
admet-514	27	11	commonly	commonly	ADV
admet-514	27	12	applied	apply	VERB
admet-514	27	13	in	in	ADP
admet-514	27	14	the	the	DET
admet-514	27	15	field	field	NOUN
admet-514	27	16	of	of	ADP
admet-514	27	17	proteomics	proteomic	NOUN
admet-514	27	18	,	,	PUNCT
admet-514	27	19	in	in	ADP
admet-514	27	20	which	which	PRON
admet-514	27	21	the	the	DET
admet-514	27	22	isolation	isolation	NOUN
admet-514	27	23	and	and	CCONJ
admet-514	27	24	analysis	analysis	NOUN
admet-514	27	25	of	of	ADP
admet-514	27	26	proteins	protein	NOUN
admet-514	27	27	based	base	VERB
admet-514	27	28	on	on	ADP
admet-514	27	29	their	their	PRON
admet-514	27	30	cellular	cellular	ADJ
admet-514	27	31	location	location	NOUN
admet-514	27	32	is	be	AUX
admet-514	27	33	a	a	DET
admet-514	27	34	rapidly	rapidly	ADV
admet-514	27	35	expanding	expand	VERB
admet-514	27	36	field	field	NOUN
admet-514	27	37	.	.	PUNCT
admet-514	28	1	however	however	ADV
admet-514	28	2	,	,	PUNCT
admet-514	28	3	the	the	DET
admet-514	28	4	different	different	ADJ
admet-514	28	5	proteins	protein	NOUN
admet-514	28	6	that	that	PRON
admet-514	28	7	make	make	VERB
admet-514	28	8	up	up	ADP
admet-514	28	9	a	a	DET
admet-514	28	10	cellular	cellular	ADJ
admet-514	28	11	environment	environment	NOUN
admet-514	28	12	differ	differ	VERB
admet-514	28	13	greatly	greatly	ADV
admet-514	28	14	and	and	CCONJ
admet-514	28	15	are	be	AUX
admet-514	28	16	difficult	difficult	ADJ
admet-514	28	17	to	to	PART
admet-514	28	18	isolate	isolate	VERB
admet-514	28	19	due	due	ADJ
admet-514	28	20	to	to	ADP
admet-514	28	21	size	size	NOUN
admet-514	28	22	,	,	PUNCT
admet-514	28	23	hydrophobicity	hydrophobicity	NOUN
admet-514	28	24	and	and	CCONJ
admet-514	28	25	basicity	basicity	NOUN
admet-514	28	26	.	.	PUNCT
admet-514	29	1	using	use	VERB
admet-514	29	2	the	the	DET
admet-514	29	3	differential	differential	ADJ
admet-514	29	4	solubility	solubility	NOUN
admet-514	29	5	of	of	ADP
admet-514	29	6	different	different	ADJ
admet-514	29	7	proteins	protein	NOUN
admet-514	29	8	in	in	ADP
admet-514	29	9	the	the	DET
admet-514	29	10	various	various	ADJ
admet-514	29	11	subcellular	subcellular	ADJ
admet-514	29	12	compartments	compartment	NOUN
admet-514	29	13	has	have	AUX
admet-514	29	14	led	lead	VERB
admet-514	29	15	to	to	ADP
admet-514	29	16	the	the	DET
admet-514	29	17	separation	separation	NOUN
admet-514	29	18	of	of	ADP
admet-514	29	19	four	four	NUM
admet-514	29	20	distinct	distinct	ADJ
admet-514	29	21	fractions	fraction	NOUN
admet-514	29	22	,	,	PUNCT
admet-514	29	23	the	the	DET
admet-514	29	24	cytosolic	cytosolic	ADJ
admet-514	29	25	fraction	fraction	NOUN
admet-514	29	26	,	,	PUNCT
admet-514	29	27	the	the	DET
admet-514	29	28	membrane	membrane	NOUN
admet-514	29	29	and	and	CCONJ
admet-514	29	30	organelle	organelle	NOUN
admet-514	29	31	fraction	fraction	NOUN
admet-514	29	32	,	,	PUNCT
admet-514	29	33	cellular	cellular	ADJ
admet-514	29	34	nucleus	nucleus	NOUN
admet-514	29	35	,	,	PUNCT
admet-514	29	36	and	and	CCONJ
admet-514	29	37	the	the	DET
admet-514	29	38	cytoskeleton	cytoskeleton	NOUN
admet-514	29	39	,	,	PUNCT
admet-514	29	40	since	since	SCONJ
admet-514	29	41	we	we	PRON
admet-514	29	42	used	use	VERB
admet-514	29	43	this	this	DET
admet-514	29	44	approach	approach	NOUN
admet-514	29	45	to	to	PART
admet-514	29	46	successfully	successfully	ADV
admet-514	29	47	characterize	characterize	VERB
admet-514	29	48	the	the	DET
admet-514	29	49	cellular	cellular	ADJ
admet-514	29	50	distribution	distribution	NOUN
admet-514	29	51	of	of	ADP
admet-514	29	52	a	a	DET
admet-514	29	53	lipophilic	lipophilic	ADJ
admet-514	29	54	prodrug	prodrug	NOUN
admet-514	29	55	of	of	ADP
admet-514	29	56	cytarabine	cytarabine	NOUN
admet-514	29	57	[	[	X
admet-514	29	58	11	11	NUM
admet-514	29	59	]	]	PUNCT
admet-514	29	60	we	we	PRON
admet-514	29	61	applied	apply	VERB
admet-514	29	62	the	the	DET
admet-514	29	63	same	same	ADJ
admet-514	29	64	methodology	methodology	NOUN
admet-514	29	65	to	to	PART
admet-514	29	66	determine	determine	VERB
admet-514	29	67	the	the	DET
admet-514	29	68	cellular	cellular	ADJ
admet-514	29	69	distribution	distribution	NOUN
admet-514	29	70	of	of	ADP
admet-514	29	71	tkis	tkis	PROPN
admet-514	29	72	.	.	PUNCT
admet-514	30	1	since	since	SCONJ
admet-514	30	2	tkis	tkis	PROPN
admet-514	30	3	are	be	AUX
admet-514	30	4	almost	almost	ADV
admet-514	30	5	completely	completely	ADV
admet-514	30	6	bound	bind	VERB
admet-514	30	7	to	to	ADP
admet-514	30	8	proteins	protein	NOUN
admet-514	30	9	,	,	PUNCT
admet-514	30	10	a	a	DET
admet-514	30	11	cellular	cellular	ADJ
admet-514	30	12	fractionation	fractionation	NOUN
admet-514	30	13	of	of	ADP
admet-514	30	14	cells	cell	NOUN
admet-514	30	15	incubated	incubate	VERB
admet-514	30	16	with	with	ADP
admet-514	30	17	drug	drug	NOUN
admet-514	30	18	for	for	ADP
admet-514	30	19	a	a	DET
admet-514	30	20	suitable	suitable	ADJ
admet-514	30	21	time	time	NOUN
admet-514	30	22	period	period	NOUN
admet-514	30	23	should	should	AUX
admet-514	30	24	also	also	ADV
admet-514	30	25	provide	provide	VERB
admet-514	30	26	fractionation	fractionation	NOUN
admet-514	30	27	of	of	ADP
admet-514	30	28	the	the	DET
admet-514	30	29	accumulated	accumulate	VERB
admet-514	30	30	tki	tki	NOUN
admet-514	30	31	.	.	PUNCT
admet-514	31	1	simple	simple	ADJ
admet-514	31	2	extraction	extraction	NOUN
admet-514	31	3	of	of	ADP
admet-514	31	4	each	each	DET
admet-514	31	5	fraction	fraction	NOUN
admet-514	31	6	should	should	AUX
admet-514	31	7	then	then	ADV
admet-514	31	8	provide	provide	VERB
admet-514	31	9	data	datum	NOUN
admet-514	31	10	on	on	ADP
admet-514	31	11	the	the	DET
admet-514	31	12	distribution	distribution	NOUN
admet-514	31	13	of	of	ADP
admet-514	31	14	the	the	DET
admet-514	31	15	tki	tki	NOUN
admet-514	31	16	within	within	ADP
admet-514	31	17	the	the	DET
admet-514	31	18	cell	cell	NOUN
admet-514	31	19	.	.	PUNCT
admet-514	32	1	using	use	VERB
admet-514	32	2	a	a	DET
admet-514	32	3	previously	previously	ADV
admet-514	32	4	developed	develop	VERB
admet-514	32	5	analytical	analytical	ADJ
admet-514	32	6	liquid	liquid	ADJ
admet-514	32	7	chromatography	chromatography	NOUN
admet-514	32	8	–	–	PUNCT
admet-514	32	9	mass	mass	NOUN
admet-514	32	10	spectrometry	spectrometry	NOUN
admet-514	32	11	method	method	NOUN
admet-514	32	12	[	[	X
admet-514	32	13	12	12	NUM
admet-514	32	14	]	]	PUNCT
admet-514	32	15	the	the	DET
admet-514	32	16	exact	exact	ADJ
admet-514	32	17	proportion	proportion	NOUN
admet-514	32	18	of	of	ADP
admet-514	32	19	tki	tki	NOUN
admet-514	32	20	can	can	AUX
admet-514	32	21	be	be	AUX
admet-514	32	22	determined	determine	VERB
admet-514	32	23	in	in	ADP
admet-514	32	24	each	each	DET
admet-514	32	25	fraction	fraction	NOUN
admet-514	32	26	with	with	ADP
admet-514	32	27	a	a	DET
admet-514	32	28	high	high	ADJ
admet-514	32	29	degree	degree	NOUN
admet-514	32	30	of	of	ADP
admet-514	32	31	specificity	specificity	NOUN
admet-514	32	32	.	.	PUNCT
admet-514	33	1	using	use	VERB
admet-514	33	2	this	this	DET
admet-514	33	3	technique	technique	NOUN
admet-514	33	4	,	,	PUNCT
admet-514	33	5	we	we	PRON
admet-514	33	6	determined	determine	VERB
admet-514	33	7	the	the	DET
admet-514	33	8	subcellular	subcellular	ADJ
admet-514	33	9	distribution	distribution	NOUN
admet-514	33	10	of	of	ADP
admet-514	33	11	six	six	NUM
admet-514	33	12	tkis	tkis	NOUN
admet-514	33	13	(	(	PUNCT
admet-514	33	14	sunitinib	sunitinib	NOUN
admet-514	33	15	,	,	PUNCT
admet-514	33	16	crizotinib	crizotinib	PROPN
admet-514	33	17	,	,	PUNCT
admet-514	33	18	erlotinib	erlotinib	NOUN
admet-514	33	19	,	,	PUNCT
admet-514	33	20	gefitinib	gefitinib	NOUN
admet-514	33	21	,	,	PUNCT
admet-514	33	22	sorafenib	sorafenib	NOUN
admet-514	33	23	and	and	CCONJ
admet-514	33	24	dasatinib	dasatinib	NOUN
admet-514	33	25	)	)	PUNCT
admet-514	33	26	within	within	ADP
admet-514	33	27	the	the	DET
admet-514	33	28	colon	colon	NOUN
admet-514	33	29	cancer	cancer	NOUN
admet-514	33	30	cell	cell	NOUN
admet-514	33	31	line	line	NOUN
admet-514	33	32	,	,	PUNCT
admet-514	33	33	caco-2	caco-2	NUM
admet-514	33	34	.	.	PUNCT
admet-514	34	1	these	these	DET
admet-514	34	2	six	six	NUM
admet-514	34	3	inhibitors	inhibitor	NOUN
admet-514	34	4	were	be	AUX
admet-514	34	5	chosen	choose	VERB
admet-514	34	6	based	base	VERB
admet-514	34	7	on	on	ADP
admet-514	34	8	their	their	PRON
admet-514	34	9	fda	fda	PROPN
admet-514	34	10	status	status	NOUN
admet-514	34	11	and	and	CCONJ
admet-514	34	12	the	the	DET
admet-514	34	13	extent	extent	NOUN
admet-514	34	14	to	to	PART
admet-514	34	15	which	which	PRON
admet-514	34	16	they	they	PRON
admet-514	34	17	are	be	AUX
admet-514	34	18	used	use	VERB
admet-514	34	19	in	in	ADP
admet-514	34	20	the	the	DET
admet-514	34	21	clinic	clinic	NOUN
admet-514	34	22	.	.	PUNCT
admet-514	35	1	each	each	PRON
admet-514	35	2	of	of	ADP
admet-514	35	3	the	the	DET
admet-514	35	4	selected	select	VERB
admet-514	35	5	molecules	molecule	NOUN
admet-514	35	6	is	be	AUX
admet-514	35	7	the	the	DET
admet-514	35	8	first	first	ADJ
admet-514	35	9	line	line	NOUN
admet-514	35	10	treatment	treatment	NOUN
admet-514	35	11	in	in	ADP
admet-514	35	12	their	their	PRON
admet-514	35	13	specific	specific	ADJ
admet-514	35	14	area	area	NOUN
admet-514	35	15	and	and	CCONJ
admet-514	35	16	regularly	regularly	ADV
admet-514	35	17	used	use	VERB
admet-514	35	18	for	for	ADP
admet-514	35	19	clinical	clinical	ADJ
admet-514	35	20	patients	patient	NOUN
admet-514	35	21	.	.	PUNCT
admet-514	36	1	materials	material	NOUN
admet-514	36	2	and	and	CCONJ
admet-514	36	3	methods	method	NOUN
admet-514	36	4	cell	cell	NOUN
admet-514	36	5	culture	culture	VERB
admet-514	36	6	the	the	DET
admet-514	36	7	caco-2	caco-2	NUM
admet-514	36	8	cell	cell	NOUN
admet-514	36	9	line	line	NOUN
admet-514	36	10	,	,	PUNCT
admet-514	36	11	originating	originate	VERB
admet-514	36	12	from	from	ADP
admet-514	36	13	a	a	DET
admet-514	36	14	colorectal	colorectal	ADJ
admet-514	36	15	adenocarcinoma	adenocarcinoma	NOUN
admet-514	36	16	,	,	PUNCT
admet-514	36	17	was	be	AUX
admet-514	36	18	cultured	cultured	ADJ
admet-514	36	19	at	at	ADP
admet-514	36	20	37	37	NUM
admet-514	36	21	°	°	NOUN
admet-514	36	22	c	c	NOUN
admet-514	36	23	,	,	PUNCT
admet-514	36	24	5	5	NUM
admet-514	36	25	%	%	NOUN
admet-514	36	26	co2	co2	NOUN
admet-514	36	27	and	and	CCONJ
admet-514	36	28	100	100	NUM
admet-514	36	29	%	%	NOUN
admet-514	36	30	humidity	humidity	NOUN
admet-514	36	31	,	,	PUNCT
admet-514	36	32	in	in	ADP
admet-514	36	33	dulbecco	dulbecco	NOUN
admet-514	36	34	’s	’s	PART
admet-514	36	35	modified	modify	VERB
admet-514	36	36	eagle	eagle	PROPN
admet-514	36	37	medium	medium	ADJ
admet-514	36	38	(	(	PUNCT
admet-514	36	39	dmem	dmem	ADJ
admet-514	36	40	)	)	PUNCT
admet-514	36	41	supplemented	supplement	VERB
admet-514	36	42	with	with	ADP
admet-514	36	43	10	10	NUM
admet-514	36	44	%	%	NOUN
admet-514	36	45	fetal	fetal	ADJ
admet-514	36	46	bovine	bovine	NOUN
admet-514	36	47	serum	serum	NOUN
admet-514	36	48	(	(	PUNCT
admet-514	36	49	fbs	fbs	PROPN
admet-514	36	50	)	)	PUNCT
admet-514	36	51	and	and	CCONJ
admet-514	36	52	20	20	NUM
admet-514	36	53	mm	mm	NOUN
admet-514	36	54	hepes	hepe	NOUN
admet-514	36	55	[	[	X
admet-514	36	56	13	13	NUM
admet-514	36	57	]	]	PUNCT
admet-514	36	58	.	.	PUNCT
admet-514	37	1	for	for	ADP
admet-514	37	2	the	the	DET
admet-514	37	3	fractionation	fractionation	NOUN
admet-514	37	4	caco-2	caco-2	NUM
admet-514	37	5	cells	cell	NOUN
admet-514	37	6	were	be	AUX
admet-514	37	7	seeded	seed	VERB
admet-514	37	8	in	in	ADP
admet-514	37	9	6	6	NUM
admet-514	37	10	ml	ml	NOUN
admet-514	37	11	dmem	dmem	VERB
admet-514	37	12	culture	culture	NOUN
admet-514	37	13	medium	medium	NOUN
admet-514	37	14	with	with	ADP
admet-514	37	15	1	1	NUM
admet-514	37	16	%	%	NOUN
admet-514	37	17	penicillin	penicillin	NOUN
admet-514	37	18	/	/	SYM
admet-514	37	19	streptomycin	streptomycin	PROPN
admet-514	37	20	in	in	ADP
admet-514	37	21	25	25	NUM
admet-514	37	22	cm2	cm2	NOUN
admet-514	37	23	flasks	flask	NOUN
admet-514	37	24	.	.	PUNCT
admet-514	38	1	cells	cell	NOUN
admet-514	38	2	were	be	AUX
admet-514	38	3	allowed	allow	VERB
admet-514	38	4	to	to	PART
admet-514	38	5	attach	attach	VERB
admet-514	38	6	and	and	CCONJ
admet-514	38	7	grow	grow	VERB
admet-514	38	8	for	for	ADP
admet-514	38	9	72	72	NUM
admet-514	38	10	hours	hour	NOUN
admet-514	38	11	(	(	PUNCT
admet-514	38	12	aiming	aim	VERB
admet-514	38	13	at	at	ADP
admet-514	38	14	an	an	DET
admet-514	38	15	ultimate	ultimate	ADJ
admet-514	38	16	cell	cell	NOUN
admet-514	38	17	number	number	NOUN
admet-514	38	18	of	of	ADP
admet-514	38	19	3	3	NUM
admet-514	38	20	-	-	PUNCT
admet-514	38	21	5x106	5x106	NUM
admet-514	38	22	cells	cell	NOUN
admet-514	38	23	)	)	PUNCT
admet-514	38	24	.	.	PUNCT
admet-514	39	1	attached	attach	VERB
admet-514	39	2	cells	cell	NOUN
admet-514	39	3	were	be	AUX
admet-514	39	4	than	than	SCONJ
admet-514	39	5	exposed	expose	VERB
admet-514	39	6	to	to	ADP
admet-514	39	7	either	either	DET
admet-514	39	8	10	10	NUM
admet-514	39	9	µm	µm	NOUN
admet-514	39	10	erlotinib	erlotinib	NOUN
admet-514	39	11	,	,	PUNCT
admet-514	39	12	gefitinib	gefitinib	NOUN
admet-514	39	13	,	,	PUNCT
admet-514	39	14	sorafenib	sorafenib	NOUN
admet-514	39	15	,	,	PUNCT
admet-514	39	16	sunitinib	sunitinib	NOUN
admet-514	39	17	,	,	PUNCT
admet-514	39	18	crizotinib	crizotinib	VERB
admet-514	39	19	or	or	CCONJ
admet-514	39	20	1	1	NUM
admet-514	39	21	µm	µm	ADP
admet-514	39	22	dasatinib	dasatinib	NOUN
admet-514	39	23	for	for	ADP
admet-514	39	24	2	2	NUM
admet-514	39	25	and	and	CCONJ
admet-514	39	26	24	24	NUM
admet-514	39	27	hours	hour	NOUN
admet-514	39	28	.	.	PUNCT
admet-514	40	1	next	next	ADJ
admet-514	40	2	,	,	PUNCT
admet-514	40	3	medium	medium	NOUN
admet-514	40	4	was	be	AUX
admet-514	40	5	aspirated	aspirate	VERB
admet-514	40	6	and	and	CCONJ
admet-514	40	7	cells	cell	NOUN
admet-514	40	8	were	be	AUX
admet-514	40	9	washed	wash	VERB
admet-514	40	10	three	three	NUM
admet-514	40	11	times	time	NOUN
admet-514	40	12	with	with	ADP
admet-514	40	13	10	10	NUM
admet-514	40	14	ml	ml	NOUN
admet-514	40	15	ice	ice	PROPN
admet-514	40	16	cold	cold	PROPN
admet-514	40	17	pbs	pbs	PROPN
admet-514	40	18	.	.	PUNCT
admet-514	41	1	to	to	ADP
admet-514	41	2	each	each	DET
admet-514	41	3	flask	flask	NOUN
admet-514	41	4	500	500	NUM
admet-514	41	5	µl	µl	NOUN
admet-514	41	6	of	of	ADP
admet-514	41	7	trypsin	trypsin	NOUN
admet-514	41	8	/	/	SYM
admet-514	41	9	edta	edta	PROPN
admet-514	41	10	was	be	AUX
admet-514	41	11	added	add	VERB
admet-514	41	12	and	and	CCONJ
admet-514	41	13	cells	cell	NOUN
admet-514	41	14	were	be	AUX
admet-514	41	15	incubated	incubate	VERB
admet-514	41	16	for	for	ADP
admet-514	41	17	about	about	ADV
admet-514	41	18	5	5	NUM
admet-514	41	19	-	-	SYM
admet-514	41	20	10	10	NUM
admet-514	41	21	minutes	minute	NOUN
admet-514	41	22	at	at	ADP
admet-514	41	23	37	37	NUM
admet-514	41	24	°	°	NOUN
admet-514	41	25	c	c	NOUN
admet-514	41	26	,	,	PUNCT
admet-514	41	27	5	5	NUM
admet-514	41	28	%	%	NOUN
admet-514	41	29	co2	co2	NOUN
admet-514	41	30	and	and	CCONJ
admet-514	41	31	100	100	NUM
admet-514	41	32	%	%	NOUN
admet-514	41	33	humidity	humidity	NOUN
admet-514	41	34	.	.	PUNCT
admet-514	42	1	when	when	SCONJ
admet-514	42	2	cells	cell	NOUN
admet-514	42	3	were	be	AUX
admet-514	42	4	detached	detach	VERB
admet-514	42	5	,	,	PUNCT
admet-514	42	6	the	the	DET
admet-514	42	7	cells	cell	NOUN
admet-514	42	8	were	be	AUX
admet-514	42	9	resuspended	resuspend	VERB
admet-514	42	10	with	with	ADP
admet-514	42	11	1.5	1.5	NUM
admet-514	42	12	ml	ml	NOUN
admet-514	42	13	ice	ice	NOUN
admet-514	42	14	cold	cold	ADJ
admet-514	42	15	phosphate	phosphate	NOUN
admet-514	42	16	buffered	buffer	VERB
admet-514	42	17	saline	saline	NOUN
admet-514	42	18	and	and	CCONJ
admet-514	42	19	transferred	transfer	VERB
admet-514	42	20	into	into	ADP
admet-514	42	21	eppendorf	eppendorf	PROPN
admet-514	42	22	tubes	tube	NOUN
admet-514	42	23	.	.	PUNCT
admet-514	43	1	after	after	ADP
admet-514	43	2	centrifugation	centrifugation	NOUN
admet-514	43	3	,	,	PUNCT
admet-514	43	4	the	the	DET
admet-514	43	5	supernatant	supernatant	NOUN
admet-514	43	6	was	be	AUX
admet-514	43	7	discarded	discard	VERB
admet-514	43	8	and	and	CCONJ
admet-514	43	9	the	the	DET
admet-514	43	10	pellets	pellet	NOUN
admet-514	43	11	resuspended	resuspend	VERB
admet-514	43	12	in	in	ADP
admet-514	43	13	200	200	NUM
admet-514	43	14	µl	µl	NOUN
admet-514	43	15	of	of	ADP
admet-514	43	16	water	water	NOUN
admet-514	43	17	for	for	ADP
admet-514	43	18	fractionation	fractionation	NOUN
admet-514	43	19	.	.	PUNCT
admet-514	44	1	cellular	cellular	ADJ
admet-514	44	2	fractionation	fractionation	NOUN
admet-514	44	3	the	the	DET
admet-514	44	4	proteoextract	proteoextract	NOUN
admet-514	44	5	®	®	NOUN
admet-514	44	6	,	,	PUNCT
admet-514	44	7	subcellular	subcellular	ADJ
admet-514	44	8	proteome	proteome	ADJ
admet-514	44	9	extraction	extraction	NOUN
admet-514	44	10	kit	kit	NOUN
admet-514	44	11	from	from	ADP
admet-514	44	12	calbiochem	calbiochem	NOUN
admet-514	44	13	(	(	PUNCT
admet-514	44	14	cat	cat	NOUN
admet-514	44	15	.	.	PUNCT
admet-514	45	1	no	no	INTJ
admet-514	45	2	.	.	NOUN
admet-514	45	3	539791	539791	NUM
admet-514	45	4	)	)	PUNCT
admet-514	45	5	,	,	PUNCT
admet-514	45	6	was	be	AUX
admet-514	45	7	used	use	VERB
admet-514	45	8	to	to	PART
admet-514	45	9	fractionate	fractionate	VERB
admet-514	45	10	the	the	DET
admet-514	45	11	cell	cell	NOUN
admet-514	45	12	pellets	pellet	NOUN
admet-514	45	13	.	.	PUNCT
admet-514	46	1	the	the	DET
admet-514	46	2	differential	differential	ADJ
admet-514	46	3	solubility	solubility	NOUN
admet-514	46	4	of	of	ADP
admet-514	46	5	proteins	protein	NOUN
admet-514	46	6	in	in	ADP
admet-514	46	7	the	the	DET
admet-514	46	8	various	various	ADJ
admet-514	46	9	subcellular	subcellular	ADJ
admet-514	46	10	fractions	fraction	NOUN
admet-514	46	11	was	be	AUX
admet-514	46	12	used	use	VERB
admet-514	46	13	to	to	PART
admet-514	46	14	isolate	isolate	VERB
admet-514	46	15	these	these	DET
admet-514	46	16	fractions	fraction	NOUN
admet-514	46	17	by	by	ADP
admet-514	46	18	the	the	DET
admet-514	46	19	addition	addition	NOUN
admet-514	46	20	of	of	ADP
admet-514	46	21	four	four	NUM
admet-514	46	22	sequential	sequential	ADJ
admet-514	46	23	extraction	extraction	NOUN
admet-514	46	24	buffers	buffer	NOUN
admet-514	46	25	.	.	PUNCT
admet-514	47	1	each	each	DET
admet-514	47	2	buffer	buffer	NOUN
admet-514	47	3	specifically	specifically	ADV
admet-514	47	4	targets	target	VERB
admet-514	47	5	a	a	DET
admet-514	47	6	subcellular	subcellular	ADJ
admet-514	47	7	compartment	compartment	NOUN
admet-514	47	8	while	while	SCONJ
admet-514	47	9	maintaining	maintain	VERB
admet-514	47	10	structural	structural	ADJ
admet-514	47	11	integrity	integrity	NOUN
admet-514	47	12	of	of	ADP
admet-514	47	13	the	the	DET
admet-514	47	14	cell	cell	NOUN
admet-514	47	15	[	[	X
admet-514	47	16	13	13	NUM
admet-514	47	17	]	]	PUNCT
admet-514	47	18	.	.	PUNCT
admet-514	48	1	when	when	SCONJ
admet-514	48	2	correctly	correctly	ADV
admet-514	48	3	applied	apply	VERB
admet-514	48	4	these	these	DET
admet-514	48	5	fractions	fraction	NOUN
admet-514	48	6	are	be	AUX
admet-514	48	7	distinct	distinct	ADJ
admet-514	48	8	and	and	CCONJ
admet-514	48	9	can	can	AUX
admet-514	48	10	separate	separate	VERB
admet-514	48	11	the	the	DET
admet-514	48	12	different	different	ADJ
admet-514	48	13	subcellular	subcellular	ADJ
admet-514	48	14	compartments	compartment	NOUN
admet-514	48	15	with	with	ADP
admet-514	48	16	minimal	minimal	PROPN
admet-514	48	17	richard	richard	PROPN
admet-514	48	18	honeywell	honeywell	PROPN
admet-514	48	19	et	et	PROPN
admet-514	48	20	al	al	PROPN
admet-514	48	21	.	.	PROPN
admet-514	48	22	admet	admet	PROPN
admet-514	48	23	&	&	CCONJ
admet-514	48	24	dmpk	dmpk	PROPN
admet-514	48	25	6(3	6(3	PROPN
admet-514	48	26	)	)	PUNCT
admet-514	48	27	(	(	PUNCT
admet-514	48	28	2018	2018	NUM
admet-514	48	29	)	)	PUNCT
admet-514	48	30	258	258	NUM
admet-514	48	31	-	-	SYM
admet-514	48	32	266	266	NUM
admet-514	48	33	260	260	NUM
admet-514	48	34	to	to	ADP
admet-514	48	35	no	no	DET
admet-514	48	36	mixing	mixing	NOUN
admet-514	48	37	.	.	PUNCT
admet-514	49	1	cell	cell	NOUN
admet-514	49	2	suspensions	suspension	NOUN
admet-514	49	3	were	be	AUX
admet-514	49	4	centrifuged	centrifuge	VERB
admet-514	49	5	at	at	ADP
admet-514	49	6	100	100	NUM
admet-514	49	7	-	-	SYM
admet-514	49	8	300	300	NUM
admet-514	49	9	g	g	NOUN
admet-514	49	10	for	for	ADP
admet-514	49	11	10	10	NUM
admet-514	49	12	minutes	minute	NOUN
admet-514	49	13	at	at	ADP
admet-514	49	14	4	4	NUM
admet-514	49	15	°	°	NOUN
admet-514	49	16	c	c	NOUN
admet-514	49	17	,	,	PUNCT
admet-514	49	18	then	then	ADV
admet-514	49	19	the	the	DET
admet-514	49	20	supernatant	supernatant	NOUN
admet-514	49	21	was	be	AUX
admet-514	49	22	removed	remove	VERB
admet-514	49	23	.	.	PUNCT
admet-514	50	1	next	next	ADV
admet-514	50	2	,	,	PUNCT
admet-514	50	3	the	the	DET
admet-514	50	4	cell	cell	NOUN
admet-514	50	5	pellets	pellet	NOUN
admet-514	50	6	were	be	AUX
admet-514	50	7	washed	wash	VERB
admet-514	50	8	with	with	ADP
admet-514	50	9	2	2	NUM
admet-514	50	10	ml	ml	NOUN
admet-514	50	11	ice	ice	NOUN
admet-514	50	12	cold	cold	ADJ
admet-514	50	13	washing	washing	NOUN
admet-514	50	14	buffer	buffer	NOUN
admet-514	50	15	,	,	PUNCT
admet-514	50	16	gently	gently	ADV
admet-514	50	17	resuspended	resuspend	VERB
admet-514	50	18	,	,	PUNCT
admet-514	50	19	incubated	incubate	VERB
admet-514	50	20	for	for	ADP
admet-514	50	21	5	5	NUM
admet-514	50	22	minutes	minute	NOUN
admet-514	50	23	at	at	ADP
admet-514	50	24	4	4	NUM
admet-514	50	25	°	°	NOUN
admet-514	50	26	c	c	NOUN
admet-514	50	27	and	and	CCONJ
admet-514	50	28	centrifuged	centrifuge	VERB
admet-514	50	29	at	at	ADP
admet-514	50	30	100	100	NUM
admet-514	50	31	-	-	SYM
admet-514	50	32	300	300	NUM
admet-514	50	33	g	g	NOUN
admet-514	50	34	at	at	ADP
admet-514	50	35	4	4	NUM
admet-514	50	36	°	°	ADP
admet-514	50	37	c	c	NOUN
admet-514	50	38	for	for	ADP
admet-514	50	39	10	10	NUM
admet-514	50	40	minutes	minute	NOUN
admet-514	50	41	.	.	PUNCT
admet-514	51	1	the	the	DET
admet-514	51	2	supernatant	supernatant	NOUN
admet-514	51	3	was	be	AUX
admet-514	51	4	discarded	discard	VERB
admet-514	51	5	and	and	CCONJ
admet-514	51	6	the	the	DET
admet-514	51	7	washing	washing	NOUN
admet-514	51	8	step	step	NOUN
admet-514	51	9	was	be	AUX
admet-514	51	10	repeated	repeat	VERB
admet-514	51	11	once	once	ADV
admet-514	51	12	more	more	ADJ
admet-514	51	13	.	.	PUNCT
admet-514	52	1	the	the	DET
admet-514	52	2	resulting	result	VERB
admet-514	52	3	cell	cell	NOUN
admet-514	52	4	pellets	pellet	NOUN
admet-514	52	5	were	be	AUX
admet-514	52	6	used	use	VERB
admet-514	52	7	to	to	PART
admet-514	52	8	separate	separate	VERB
admet-514	52	9	4	4	NUM
admet-514	52	10	distinct	distinct	ADJ
admet-514	52	11	cellular	cellular	ADJ
admet-514	52	12	compartments	compartment	NOUN
admet-514	52	13	.	.	PUNCT
admet-514	53	1	the	the	DET
admet-514	53	2	initial	initial	ADJ
admet-514	53	3	stage	stage	NOUN
admet-514	53	4	of	of	ADP
admet-514	53	5	the	the	DET
admet-514	53	6	extraction	extraction	NOUN
admet-514	53	7	releases	release	VERB
admet-514	53	8	the	the	DET
admet-514	53	9	cytosolic	cytosolic	ADJ
admet-514	53	10	proteins	protein	NOUN
admet-514	53	11	from	from	ADP
admet-514	53	12	the	the	DET
admet-514	53	13	cell	cell	NOUN
admet-514	53	14	,	,	PUNCT
admet-514	53	15	by	by	ADP
admet-514	53	16	addition	addition	NOUN
admet-514	53	17	of	of	ADP
admet-514	53	18	1	1	NUM
admet-514	53	19	ml	ml	NOUN
admet-514	53	20	of	of	ADP
admet-514	53	21	ice	ice	NOUN
admet-514	53	22	cold	cold	ADJ
admet-514	53	23	extraction	extraction	NOUN
admet-514	53	24	buffer	buffer	NOUN
admet-514	53	25	i	i	PRON
admet-514	53	26	with	with	ADP
admet-514	53	27	5	5	NUM
admet-514	53	28	µl	µl	ADP
admet-514	53	29	protease	protease	NOUN
admet-514	53	30	inhibitor	inhibitor	NOUN
admet-514	53	31	cocktail	cocktail	NOUN
admet-514	53	32	(	(	PUNCT
admet-514	53	33	pic	pic	NOUN
admet-514	53	34	)	)	PUNCT
admet-514	53	35	to	to	ADP
admet-514	53	36	each	each	DET
admet-514	53	37	cell	cell	NOUN
admet-514	53	38	pellet	pellet	NOUN
admet-514	53	39	,	,	PUNCT
admet-514	53	40	which	which	PRON
admet-514	53	41	were	be	AUX
admet-514	53	42	incubated	incubate	VERB
admet-514	53	43	for	for	ADP
admet-514	53	44	10	10	NUM
admet-514	53	45	minutes	minute	NOUN
admet-514	53	46	at	at	ADP
admet-514	53	47	4	4	NUM
admet-514	53	48	°	°	NOUN
admet-514	53	49	c	c	NOUN
admet-514	53	50	and	and	CCONJ
admet-514	53	51	centrifuged	centrifuge	VERB
admet-514	53	52	at	at	ADP
admet-514	53	53	500	500	NUM
admet-514	53	54	-	-	SYM
admet-514	53	55	1000	1000	NUM
admet-514	53	56	g	g	NOUN
admet-514	53	57	at	at	ADP
admet-514	53	58	4	4	NUM
admet-514	53	59	°	°	ADP
admet-514	53	60	c	c	NOUN
admet-514	53	61	for	for	ADP
admet-514	53	62	10	10	NUM
admet-514	53	63	minutes	minute	NOUN
admet-514	53	64	.	.	PUNCT
admet-514	54	1	the	the	DET
admet-514	54	2	supernatant	supernatant	NOUN
admet-514	54	3	was	be	AUX
admet-514	54	4	then	then	ADV
admet-514	54	5	transferred	transfer	VERB
admet-514	54	6	quantitatively	quantitatively	ADV
admet-514	54	7	into	into	ADP
admet-514	54	8	a	a	DET
admet-514	54	9	clean	clean	ADJ
admet-514	54	10	labelled	label	VERB
admet-514	54	11	tube	tube	NOUN
admet-514	54	12	without	without	ADP
admet-514	54	13	disturbing	disturb	VERB
admet-514	54	14	the	the	DET
admet-514	54	15	pellet	pellet	NOUN
admet-514	54	16	(	(	PUNCT
admet-514	54	17	fraction	fraction	NOUN
admet-514	54	18	1	1	NUM
admet-514	54	19	,	,	PUNCT
admet-514	54	20	representing	represent	VERB
admet-514	54	21	the	the	DET
admet-514	54	22	cytosolic	cytosolic	ADJ
admet-514	54	23	proteins	protein	NOUN
admet-514	54	24	)	)	PUNCT
admet-514	54	25	and	and	CCONJ
admet-514	54	26	stored	store	VERB
admet-514	54	27	at	at	ADP
admet-514	54	28	-80	-80	NOUN
admet-514	54	29	°	°	ADP
admet-514	54	30	c	c	NOUN
admet-514	54	31	for	for	ADP
admet-514	54	32	future	future	ADJ
admet-514	54	33	analysis	analysis	NOUN
admet-514	54	34	.	.	PUNCT
admet-514	55	1	subsequently	subsequently	ADV
admet-514	55	2	,	,	PUNCT
admet-514	55	3	1	1	NUM
admet-514	55	4	ml	ml	NOUN
admet-514	55	5	of	of	ADP
admet-514	55	6	ice	ice	NOUN
admet-514	55	7	cold	cold	ADJ
admet-514	55	8	extraction	extraction	NOUN
admet-514	55	9	buffer	buffer	NOUN
admet-514	55	10	ii	ii	PROPN
admet-514	55	11	with	with	ADP
admet-514	55	12	5	5	NUM
admet-514	55	13	µl	µl	ADP
admet-514	55	14	pic	pic	NOUN
admet-514	55	15	was	be	AUX
admet-514	55	16	added	add	VERB
admet-514	55	17	to	to	ADP
admet-514	55	18	each	each	DET
admet-514	55	19	pellet	pellet	NOUN
admet-514	55	20	to	to	PART
admet-514	55	21	solubilize	solubilize	VERB
admet-514	55	22	the	the	DET
admet-514	55	23	membrane	membrane	NOUN
admet-514	55	24	and	and	CCONJ
admet-514	55	25	organelles	organelle	NOUN
admet-514	55	26	fraction	fraction	NOUN
admet-514	55	27	,	,	PUNCT
admet-514	55	28	incubated	incubate	VERB
admet-514	55	29	for	for	ADP
admet-514	55	30	30	30	NUM
admet-514	55	31	minutes	minute	NOUN
admet-514	55	32	at	at	ADP
admet-514	55	33	4	4	NUM
admet-514	55	34	°	°	ADP
admet-514	55	35	c	c	NOUN
admet-514	55	36	and	and	CCONJ
admet-514	55	37	then	then	ADV
admet-514	55	38	centrifuged	centrifuge	VERB
admet-514	55	39	at	at	ADP
admet-514	55	40	5000	5000	NUM
admet-514	55	41	-	-	SYM
admet-514	55	42	6000	6000	NUM
admet-514	55	43	g	g	NOUN
admet-514	55	44	at	at	ADP
admet-514	55	45	4	4	NUM
admet-514	55	46	°	°	ADP
admet-514	55	47	c	c	NOUN
admet-514	55	48	for	for	ADP
admet-514	55	49	10	10	NUM
admet-514	55	50	minutes	minute	NOUN
admet-514	55	51	.	.	PUNCT
admet-514	56	1	the	the	DET
admet-514	56	2	supernatant	supernatant	NOUN
admet-514	56	3	was	be	AUX
admet-514	56	4	transferred	transfer	VERB
admet-514	56	5	quantitatively	quantitatively	ADV
admet-514	56	6	into	into	ADP
admet-514	56	7	a	a	DET
admet-514	56	8	clean	clean	ADJ
admet-514	56	9	tube	tube	NOUN
admet-514	56	10	without	without	ADP
admet-514	56	11	disturbing	disturb	VERB
admet-514	56	12	the	the	DET
admet-514	56	13	pellet	pellet	NOUN
admet-514	56	14	(	(	PUNCT
admet-514	56	15	fraction	fraction	NOUN
admet-514	56	16	2	2	NUM
admet-514	56	17	representing	represent	VERB
admet-514	56	18	the	the	DET
admet-514	56	19	membrane	membrane	NOUN
admet-514	56	20	and	and	CCONJ
admet-514	56	21	organelle	organelle	NOUN
admet-514	56	22	proteins	protein	NOUN
admet-514	56	23	)	)	PUNCT
admet-514	56	24	and	and	CCONJ
admet-514	56	25	stored	store	VERB
admet-514	56	26	at	at	ADP
admet-514	56	27	-80	-80	NOUN
admet-514	56	28	°	°	NOUN
admet-514	56	29	c	c	NOUN
admet-514	56	30	for	for	ADP
admet-514	56	31	future	future	ADJ
admet-514	56	32	analysis	analysis	NOUN
admet-514	56	33	.	.	PUNCT
admet-514	57	1	next	next	ADJ
admet-514	57	2	,	,	PUNCT
admet-514	57	3	500	500	NUM
admet-514	57	4	µl	µl	NOUN
admet-514	57	5	of	of	ADP
admet-514	57	6	ice	ice	NOUN
admet-514	57	7	cold	cold	ADJ
admet-514	57	8	extraction	extraction	NOUN
admet-514	57	9	buffer	buffer	NOUN
admet-514	57	10	iii	iii	NOUN
admet-514	57	11	with	with	ADP
admet-514	57	12	5	5	NUM
admet-514	57	13	µl	µl	ADP
admet-514	57	14	pic	pic	NOUN
admet-514	57	15	and	and	CCONJ
admet-514	57	16	1.5	1.5	NUM
admet-514	57	17	µl	µl	ADP
admet-514	57	18	benzonase	benzonase	NOUN
admet-514	57	19	nuclease	nuclease	NOUN
admet-514	57	20	was	be	AUX
admet-514	57	21	added	add	VERB
admet-514	57	22	to	to	ADP
admet-514	57	23	each	each	DET
admet-514	57	24	pellet	pellet	NOUN
admet-514	57	25	,	,	PUNCT
admet-514	57	26	incubated	incubate	VERB
admet-514	57	27	for	for	ADP
admet-514	57	28	10	10	NUM
admet-514	57	29	minutes	minute	NOUN
admet-514	57	30	at	at	ADP
admet-514	57	31	4	4	NUM
admet-514	57	32	°	°	NOUN
admet-514	57	33	c	c	NOUN
admet-514	57	34	and	and	CCONJ
admet-514	57	35	centrifuged	centrifuge	VERB
admet-514	57	36	at	at	ADP
admet-514	57	37	6800	6800	NUM
admet-514	57	38	g	g	NOUN
admet-514	57	39	at	at	ADP
admet-514	57	40	4	4	NUM
admet-514	57	41	°	°	ADP
admet-514	57	42	c	c	NOUN
admet-514	57	43	for	for	ADP
admet-514	57	44	10	10	NUM
admet-514	57	45	minutes	minute	NOUN
admet-514	57	46	.	.	PUNCT
admet-514	58	1	the	the	DET
admet-514	58	2	supernatant	supernatant	NOUN
admet-514	58	3	was	be	AUX
admet-514	58	4	transferred	transfer	VERB
admet-514	58	5	into	into	ADP
admet-514	58	6	a	a	DET
admet-514	58	7	clean	clean	ADJ
admet-514	58	8	tube	tube	NOUN
admet-514	58	9	without	without	ADP
admet-514	58	10	disturbing	disturb	VERB
admet-514	58	11	the	the	DET
admet-514	58	12	pellet	pellet	NOUN
admet-514	58	13	,	,	PUNCT
admet-514	58	14	containing	contain	VERB
admet-514	58	15	nuclear	nuclear	ADJ
admet-514	58	16	proteins	protein	NOUN
admet-514	58	17	(	(	PUNCT
admet-514	58	18	fraction	fraction	NOUN
admet-514	58	19	3	3	NUM
admet-514	58	20	)	)	PUNCT
admet-514	58	21	and	and	CCONJ
admet-514	58	22	stored	store	VERB
admet-514	58	23	at	at	ADP
admet-514	58	24	-80	-80	NOUN
admet-514	58	25	°	°	ADP
admet-514	58	26	c	c	NOUN
admet-514	58	27	for	for	ADP
admet-514	58	28	future	future	ADJ
admet-514	58	29	analysis	analysis	NOUN
admet-514	58	30	.	.	PUNCT
admet-514	59	1	the	the	DET
admet-514	59	2	last	last	ADJ
admet-514	59	3	stage	stage	NOUN
admet-514	59	4	was	be	AUX
admet-514	59	5	to	to	PART
admet-514	59	6	add	add	VERB
admet-514	59	7	500	500	NUM
admet-514	59	8	µl	µl	NOUN
admet-514	59	9	of	of	ADP
admet-514	59	10	extraction	extraction	NOUN
admet-514	59	11	buffer	buffer	NOUN
admet-514	59	12	iv	iv	ADP
admet-514	59	13	with	with	ADP
admet-514	59	14	5	5	NUM
admet-514	59	15	µl	µl	ADP
admet-514	59	16	pic	pic	NOUN
admet-514	59	17	to	to	ADP
admet-514	59	18	each	each	DET
admet-514	59	19	cell	cell	NOUN
admet-514	59	20	pellet	pellet	NOUN
admet-514	59	21	,	,	PUNCT
admet-514	59	22	obtaining	obtain	VERB
admet-514	59	23	the	the	DET
admet-514	59	24	components	component	NOUN
admet-514	59	25	of	of	ADP
admet-514	59	26	the	the	DET
admet-514	59	27	cytoskeleton	cytoskeleton	NOUN
admet-514	59	28	(	(	PUNCT
admet-514	59	29	fraction	fraction	NOUN
admet-514	59	30	4	4	NUM
admet-514	59	31	)	)	PUNCT
admet-514	59	32	and	and	CCONJ
admet-514	59	33	stored	store	VERB
admet-514	59	34	at	at	ADP
admet-514	59	35	-80	-80	NOUN
admet-514	59	36	°	°	ADP
admet-514	59	37	c	c	NOUN
admet-514	59	38	for	for	ADP
admet-514	59	39	future	future	ADJ
admet-514	59	40	analysis	analysis	NOUN
admet-514	59	41	.	.	PUNCT
admet-514	60	1	data	datum	NOUN
admet-514	60	2	analysis	analysis	NOUN
admet-514	60	3	by	by	ADP
admet-514	60	4	lc	lc	PROPN
admet-514	60	5	-	-	PUNCT
admet-514	60	6	ms	ms	PROPN
admet-514	60	7	/	/	SYM
admet-514	60	8	ms	ms	NOUN
admet-514	60	9	all	all	DET
admet-514	60	10	samples	sample	NOUN
admet-514	60	11	of	of	ADP
admet-514	60	12	the	the	DET
admet-514	60	13	subcellular	subcellular	ADJ
admet-514	60	14	fractionation	fractionation	NOUN
admet-514	60	15	were	be	AUX
admet-514	60	16	measured	measure	VERB
admet-514	60	17	using	use	VERB
admet-514	60	18	liquid	liquid	ADJ
admet-514	60	19	chromatography	chromatography	NOUN
admet-514	60	20	coupled	couple	VERB
admet-514	60	21	to	to	PART
admet-514	60	22	mass	mass	VERB
admet-514	60	23	spectrometry	spectrometry	NOUN
admet-514	60	24	to	to	PART
admet-514	60	25	determine	determine	VERB
admet-514	60	26	the	the	DET
admet-514	60	27	amount	amount	NOUN
admet-514	60	28	of	of	ADP
admet-514	60	29	drug	drug	NOUN
admet-514	60	30	(	(	PUNCT
admet-514	60	31	tki	tki	NOUN
admet-514	60	32	)	)	PUNCT
admet-514	60	33	present	present	NOUN
admet-514	60	34	using	use	VERB
admet-514	60	35	a	a	DET
admet-514	60	36	previously	previously	ADV
admet-514	60	37	developed	develop	VERB
admet-514	60	38	method	method	NOUN
admet-514	60	39	for	for	ADP
admet-514	60	40	biological	biological	ADJ
admet-514	60	41	materials	material	NOUN
admet-514	60	42	.	.	PUNCT
admet-514	61	1	briefly	briefly	ADV
admet-514	61	2	,	,	PUNCT
admet-514	61	3	20	20	NUM
admet-514	61	4	µl	µl	NOUN
admet-514	61	5	of	of	ADP
admet-514	61	6	each	each	DET
admet-514	61	7	supernatant	supernatant	NOUN
admet-514	61	8	fraction	fraction	NOUN
admet-514	61	9	was	be	AUX
admet-514	61	10	transferred	transfer	VERB
admet-514	61	11	quantitatively	quantitatively	ADV
admet-514	61	12	into	into	ADP
admet-514	61	13	a	a	DET
admet-514	61	14	round	round	NOUN
admet-514	61	15	bottomed	bottom	VERB
admet-514	61	16	96	96	NUM
admet-514	61	17	-	-	PUNCT
admet-514	61	18	well	well	NOUN
admet-514	61	19	plate	plate	NOUN
admet-514	61	20	and	and	CCONJ
admet-514	61	21	80	80	NUM
admet-514	61	22	µl	µl	NOUN
admet-514	61	23	of	of	ADP
admet-514	61	24	ice	ice	NOUN
admet-514	61	25	cold	cold	ADJ
admet-514	61	26	acetonitrile	acetonitrile	NOUN
admet-514	61	27	added	add	VERB
admet-514	61	28	.	.	PUNCT
admet-514	62	1	each	each	DET
admet-514	62	2	plate	plate	NOUN
admet-514	62	3	was	be	AUX
admet-514	62	4	covered	cover	VERB
admet-514	62	5	with	with	ADP
admet-514	62	6	a	a	DET
admet-514	62	7	plastic	plastic	ADJ
admet-514	62	8	foil	foil	NOUN
admet-514	62	9	and	and	CCONJ
admet-514	62	10	allowed	allow	VERB
admet-514	62	11	to	to	PART
admet-514	62	12	stand	stand	VERB
admet-514	62	13	for	for	ADP
admet-514	62	14	10	10	NUM
admet-514	62	15	minutes	minute	NOUN
admet-514	62	16	.	.	PUNCT
admet-514	63	1	subsequently	subsequently	ADV
admet-514	63	2	the	the	DET
admet-514	63	3	96	96	NUM
admet-514	63	4	-	-	PUNCT
admet-514	63	5	well	well	NOUN
admet-514	63	6	plate	plate	NOUN
admet-514	63	7	was	be	AUX
admet-514	63	8	centrifuged	centrifuge	VERB
admet-514	63	9	at	at	ADP
admet-514	63	10	1500	1500	NUM
admet-514	63	11	g	g	NOUN
admet-514	63	12	at	at	ADP
admet-514	63	13	4	4	NUM
admet-514	63	14	°	°	ADP
admet-514	63	15	c	c	NOUN
admet-514	63	16	for	for	ADP
admet-514	63	17	10	10	NUM
admet-514	63	18	minutes	minute	NOUN
admet-514	63	19	.	.	PUNCT
admet-514	64	1	next	next	ADJ
admet-514	64	2	,	,	PUNCT
admet-514	64	3	50	50	NUM
admet-514	64	4	µl	µl	NOUN
admet-514	64	5	of	of	ADP
admet-514	64	6	each	each	DET
admet-514	64	7	sample	sample	NOUN
admet-514	64	8	was	be	AUX
admet-514	64	9	transferred	transfer	VERB
admet-514	64	10	to	to	ADP
admet-514	64	11	a	a	DET
admet-514	64	12	clean	clean	ADJ
admet-514	64	13	conical	conical	NOUN
admet-514	64	14	96	96	NUM
admet-514	64	15	-	-	PUNCT
admet-514	64	16	well	well	NOUN
admet-514	64	17	plate	plate	NOUN
admet-514	64	18	and	and	CCONJ
admet-514	64	19	covered	cover	VERB
admet-514	64	20	with	with	ADP
admet-514	64	21	a	a	DET
admet-514	64	22	nunc	nunc	NOUN
admet-514	64	23	well	well	NOUN
admet-514	64	24	plate	plate	NOUN
admet-514	64	25	seal	seal	NOUN
admet-514	64	26	.	.	PUNCT
admet-514	65	1	lastly	lastly	ADV
admet-514	65	2	,	,	PUNCT
admet-514	65	3	1	1	NUM
admet-514	65	4	µl	µl	ADP
admet-514	65	5	of	of	ADP
admet-514	65	6	each	each	DET
admet-514	65	7	sample	sample	NOUN
admet-514	65	8	was	be	AUX
admet-514	65	9	injected	inject	VERB
admet-514	65	10	into	into	ADP
admet-514	65	11	the	the	DET
admet-514	65	12	lc	lc	PROPN
admet-514	65	13	-	-	PUNCT
admet-514	65	14	ms	ms	PROPN
admet-514	65	15	/	/	PROPN
admet-514	65	16	ms	ms	NOUN
admet-514	65	17	under	under	ADP
admet-514	65	18	the	the	DET
admet-514	65	19	following	following	ADJ
admet-514	65	20	conditions	condition	NOUN
admet-514	65	21	.	.	PUNCT
admet-514	66	1	a	a	DET
admet-514	66	2	mobile	mobile	ADJ
admet-514	66	3	phase	phase	NOUN
admet-514	66	4	containing	contain	VERB
admet-514	66	5	0.578	0.578	NUM
admet-514	66	6	g	g	PROPN
admet-514	66	7	ammonium	ammonium	NOUN
admet-514	66	8	acetate	acetate	NOUN
admet-514	66	9	,	,	PUNCT
admet-514	66	10	375	375	NUM
admet-514	66	11	ml	ml	NOUN
admet-514	66	12	milliq	milliq	NOUN
admet-514	66	13	water	water	NOUN
admet-514	66	14	,	,	PUNCT
admet-514	66	15	125	125	NUM
admet-514	66	16	ml	ml	NOUN
admet-514	66	17	methanol	methanol	NOUN
admet-514	66	18	,	,	PUNCT
admet-514	66	19	0.1	0.1	NUM
admet-514	66	20	%	%	NOUN
admet-514	66	21	isopropanol	isopropanol	NOUN
admet-514	66	22	and	and	CCONJ
admet-514	66	23	1000	1000	NUM
admet-514	66	24	ml	ml	NOUN
admet-514	66	25	acetonitrile	acetonitrile	NOUN
admet-514	66	26	with	with	ADP
admet-514	66	27	a	a	DET
admet-514	66	28	ph	ph	NOUN
admet-514	66	29	of	of	ADP
admet-514	66	30	7.8	7.8	NUM
admet-514	66	31	was	be	AUX
admet-514	66	32	used	use	VERB
admet-514	66	33	at	at	ADP
admet-514	66	34	350	350	NUM
admet-514	66	35	µl	µl	NOUN
admet-514	66	36	/	/	SYM
admet-514	66	37	min	min	NOUN
admet-514	66	38	.	.	PROPN
admet-514	66	39	before	before	ADP
admet-514	66	40	use	use	NOUN
admet-514	66	41	,	,	PUNCT
admet-514	66	42	the	the	DET
admet-514	66	43	mobile	mobile	ADJ
admet-514	66	44	phase	phase	NOUN
admet-514	66	45	was	be	AUX
admet-514	66	46	filtered	filter	VERB
admet-514	66	47	using	use	VERB
admet-514	66	48	a	a	DET
admet-514	66	49	nylon	nylon	NOUN
admet-514	66	50	filter	filter	NOUN
admet-514	66	51	paper	paper	NOUN
admet-514	66	52	of	of	ADP
admet-514	66	53	0.2	0.2	NUM
admet-514	66	54	µm	µm	NOUN
admet-514	66	55	and	and	CCONJ
admet-514	66	56	subsequently	subsequently	ADV
admet-514	66	57	degassed	degas	VERB
admet-514	66	58	for	for	ADP
admet-514	66	59	10	10	NUM
admet-514	66	60	minutes	minute	NOUN
admet-514	66	61	.	.	PUNCT
admet-514	67	1	chromatography	chromatography	NOUN
admet-514	67	2	was	be	AUX
admet-514	67	3	performed	perform	VERB
admet-514	67	4	on	on	ADP
admet-514	67	5	a	a	DET
admet-514	67	6	phenomenex	phenomenex	ADV
admet-514	67	7	prodigy	prodigy	NOUN
admet-514	67	8	ods	ods	PROPN
admet-514	67	9	3	3	NUM
admet-514	67	10	column	column	NOUN
admet-514	67	11	(	(	PUNCT
admet-514	67	12	100x2	100x2	NUM
admet-514	67	13	mm	mm	NOUN
admet-514	67	14	,	,	PUNCT
admet-514	67	15	3	3	NUM
admet-514	67	16	µm	µm	NOUN
admet-514	67	17	)	)	PUNCT
admet-514	67	18	.	.	PUNCT
admet-514	68	1	data	datum	NOUN
admet-514	68	2	analysis	analysis	NOUN
admet-514	68	3	concentration	concentration	NOUN
admet-514	68	4	of	of	ADP
admet-514	68	5	compounds	compound	NOUN
admet-514	68	6	determined	determine	VERB
admet-514	68	7	by	by	ADP
admet-514	68	8	lc	lc	PROPN
admet-514	68	9	-	-	PUNCT
admet-514	68	10	ms	ms	PROPN
admet-514	68	11	/	/	PROPN
admet-514	68	12	ms	ms	NOUN
admet-514	68	13	in	in	ADP
admet-514	68	14	each	each	PRON
admet-514	68	15	of	of	ADP
admet-514	68	16	the	the	DET
admet-514	68	17	fractions	fraction	NOUN
admet-514	68	18	was	be	AUX
admet-514	68	19	normalized	normalize	VERB
admet-514	68	20	to	to	PART
admet-514	68	21	total	total	VERB
admet-514	68	22	volume	volume	NOUN
admet-514	68	23	of	of	ADP
admet-514	68	24	the	the	DET
admet-514	68	25	collected	collect	VERB
admet-514	68	26	fraction	fraction	NOUN
admet-514	68	27	and	and	CCONJ
admet-514	68	28	quantified	quantify	VERB
admet-514	68	29	as	as	ADP
admet-514	68	30	accumulated	accumulate	VERB
admet-514	68	31	drug	drug	NOUN
admet-514	68	32	within	within	ADP
admet-514	68	33	each	each	DET
admet-514	68	34	fraction	fraction	NOUN
admet-514	68	35	(	(	PUNCT
admet-514	68	36	fmol	fmol	NOUN
admet-514	68	37	)	)	PUNCT
admet-514	68	38	.	.	PUNCT
admet-514	69	1	protein	protein	NOUN
admet-514	69	2	content	content	NOUN
admet-514	69	3	of	of	ADP
admet-514	69	4	each	each	DET
admet-514	69	5	fraction	fraction	NOUN
admet-514	69	6	was	be	AUX
admet-514	69	7	determined	determine	VERB
admet-514	69	8	and	and	CCONJ
admet-514	69	9	data	datum	NOUN
admet-514	69	10	normalised	normalise	VERB
admet-514	69	11	to	to	ADP
admet-514	69	12	fmol	fmol	VERB
admet-514	69	13	/	/	SYM
admet-514	69	14	mg	mg	PROPN
admet-514	69	15	protein	protein	NOUN
admet-514	69	16	.	.	PUNCT
admet-514	70	1	the	the	DET
admet-514	70	2	percentage	percentage	NOUN
admet-514	70	3	of	of	ADP
admet-514	70	4	drug	drug	NOUN
admet-514	70	5	observed	observe	VERB
admet-514	70	6	in	in	ADP
admet-514	70	7	each	each	DET
admet-514	70	8	fraction	fraction	NOUN
admet-514	70	9	was	be	AUX
admet-514	70	10	then	then	ADV
admet-514	70	11	determined	determine	VERB
admet-514	70	12	in	in	ADP
admet-514	70	13	relation	relation	NOUN
admet-514	70	14	to	to	ADP
admet-514	70	15	the	the	DET
admet-514	70	16	total	total	ADJ
admet-514	70	17	drug	drug	NOUN
admet-514	70	18	accumulation	accumulation	NOUN
admet-514	70	19	(	(	PUNCT
admet-514	70	20	the	the	DET
admet-514	70	21	sum	sum	NOUN
admet-514	70	22	total	total	NOUN
admet-514	70	23	of	of	ADP
admet-514	70	24	all	all	DET
admet-514	70	25	fractions	fraction	NOUN
admet-514	70	26	per	per	ADP
admet-514	70	27	compound	compound	NOUN
admet-514	70	28	)	)	PUNCT
admet-514	70	29	.	.	PUNCT
admet-514	71	1	fold	fold	VERB
admet-514	71	2	changes	change	NOUN
admet-514	71	3	between	between	ADP
admet-514	71	4	the	the	DET
admet-514	71	5	2	2	NUM
admet-514	71	6	hour	hour	NOUN
admet-514	71	7	and	and	CCONJ
admet-514	71	8	24	24	NUM
admet-514	71	9	hour	hour	NOUN
admet-514	71	10	accumulation	accumulation	NOUN
admet-514	71	11	time	time	NOUN
admet-514	71	12	points	point	NOUN
admet-514	71	13	were	be	AUX
admet-514	71	14	determined	determine	VERB
admet-514	71	15	as	as	ADP
admet-514	71	16	the	the	DET
admet-514	71	17	ratio	ratio	NOUN
admet-514	71	18	of	of	ADP
admet-514	71	19	total	total	ADJ
admet-514	71	20	drug	drug	NOUN
admet-514	71	21	accumulated	accumulate	VERB
admet-514	71	22	at	at	ADP
admet-514	71	23	the	the	DET
admet-514	71	24	2	2	NUM
admet-514	71	25	hour	hour	NOUN
admet-514	71	26	mark	mark	NOUN
admet-514	71	27	to	to	ADP
admet-514	71	28	the	the	DET
admet-514	71	29	total	total	NOUN
admet-514	71	30	accumulated	accumulate	VERB
admet-514	71	31	at	at	ADP
admet-514	71	32	the	the	DET
admet-514	71	33	24	24	NUM
admet-514	71	34	hour	hour	NOUN
admet-514	71	35	time	time	NOUN
admet-514	71	36	mark	mark	NOUN
admet-514	71	37	.	.	PUNCT
admet-514	72	1	admet	admet	PROPN
admet-514	72	2	&	&	CCONJ
admet-514	72	3	dmpk	dmpk	PROPN
admet-514	72	4	6(3	6(3	PROPN
admet-514	72	5	)	)	PUNCT
admet-514	72	6	(	(	PUNCT
admet-514	72	7	2018	2018	NUM
admet-514	72	8	)	)	PUNCT
admet-514	72	9	258	258	NUM
admet-514	72	10	-	-	PUNCT
admet-514	72	11	266	266	NUM
admet-514	72	12	subcellular	subcellular	ADJ
admet-514	72	13	localization	localization	NOUN
admet-514	72	14	of	of	ADP
admet-514	72	15	several	several	ADJ
admet-514	72	16	structurally	structurally	ADV
admet-514	72	17	different	different	ADJ
admet-514	72	18	tkis	tkis	PROPN
admet-514	72	19	doi	doi	NOUN
admet-514	72	20	:	:	PUNCT
admet-514	72	21	10.5599	10.5599	NUM
admet-514	72	22	/	/	SYM
admet-514	72	23	admet.514	admet.514	PROPN
admet-514	72	24	261	261	NUM
admet-514	72	25	results	result	NOUN
admet-514	72	26	using	use	VERB
admet-514	72	27	the	the	DET
admet-514	72	28	proteome	proteome	PROPN
admet-514	72	29	extraction	extraction	NOUN
admet-514	72	30	kit	kit	NOUN
admet-514	72	31	we	we	PRON
admet-514	72	32	managed	manage	VERB
admet-514	72	33	to	to	PART
admet-514	72	34	separate	separate	VERB
admet-514	72	35	the	the	DET
admet-514	72	36	proteins	protein	NOUN
admet-514	72	37	bound	bind	VERB
admet-514	72	38	into	into	ADP
admet-514	72	39	representative	representative	ADJ
admet-514	72	40	fractions	fraction	NOUN
admet-514	72	41	of	of	ADP
admet-514	72	42	the	the	DET
admet-514	72	43	cellular	cellular	ADJ
admet-514	72	44	compartments	compartment	NOUN
admet-514	72	45	,	,	PUNCT
admet-514	72	46	even	even	ADV
admet-514	72	47	when	when	SCONJ
admet-514	72	48	accumulated	accumulate	VERB
admet-514	72	49	at	at	ADP
admet-514	72	50	very	very	ADV
admet-514	72	51	low	low	ADJ
admet-514	72	52	levels	level	NOUN
admet-514	72	53	.	.	PUNCT
admet-514	73	1	sunitinib	sunitinib	NOUN
admet-514	73	2	has	have	AUX
admet-514	73	3	previously	previously	ADV
admet-514	73	4	been	be	AUX
admet-514	73	5	shown	show	VERB
admet-514	73	6	to	to	PART
admet-514	73	7	accumulate	accumulate	VERB
admet-514	73	8	within	within	ADP
admet-514	73	9	the	the	DET
admet-514	73	10	lysosomal	lysosomal	ADJ
admet-514	73	11	compartment	compartment	NOUN
admet-514	73	12	of	of	ADP
admet-514	73	13	the	the	DET
admet-514	73	14	cellular	cellular	ADJ
admet-514	73	15	makeup	makeup	NOUN
admet-514	73	16	,	,	PUNCT
admet-514	73	17	where	where	SCONJ
admet-514	73	18	it	it	PRON
admet-514	73	19	can	can	AUX
admet-514	73	20	reach	reach	VERB
admet-514	73	21	very	very	ADV
admet-514	73	22	high	high	ADJ
admet-514	73	23	concentrations	concentration	NOUN
admet-514	73	24	.	.	PUNCT
admet-514	74	1	hence	hence	ADV
admet-514	74	2	,	,	PUNCT
admet-514	74	3	sunitinib	sunitinib	NOUN
admet-514	74	4	was	be	AUX
admet-514	74	5	used	use	VERB
admet-514	74	6	as	as	ADP
admet-514	74	7	a	a	DET
admet-514	74	8	control	control	NOUN
admet-514	74	9	for	for	ADP
admet-514	74	10	the	the	DET
admet-514	74	11	occurrence	occurrence	NOUN
admet-514	74	12	of	of	ADP
admet-514	74	13	lysosomal	lysosomal	ADJ
admet-514	74	14	accumulation	accumulation	NOUN
admet-514	74	15	.	.	PUNCT
admet-514	75	1	as	as	SCONJ
admet-514	75	2	expected	expect	VERB
admet-514	75	3	after	after	SCONJ
admet-514	75	4	2	2	NUM
admet-514	75	5	hours	hour	NOUN
admet-514	75	6	sunitinib	sunitinib	NOUN
admet-514	75	7	was	be	AUX
admet-514	75	8	predominantly	predominantly	ADV
admet-514	75	9	located	locate	VERB
admet-514	75	10	in	in	ADP
admet-514	75	11	the	the	DET
admet-514	75	12	cytosol	cytosol	NOUN
admet-514	75	13	(	(	PUNCT
admet-514	75	14	57.5	57.5	NUM
admet-514	75	15	%	%	NOUN
admet-514	75	16	)	)	PUNCT
admet-514	75	17	,	,	PUNCT
admet-514	75	18	membranes	membrane	NOUN
admet-514	75	19	and	and	CCONJ
admet-514	75	20	membrane	membrane	NOUN
admet-514	75	21	organelles	organelle	NOUN
admet-514	75	22	(	(	PUNCT
admet-514	75	23	42.1	42.1	NUM
admet-514	75	24	%	%	NOUN
admet-514	75	25	)	)	PUNCT
admet-514	75	26	(	(	PUNCT
admet-514	75	27	e.g.	e.g.	ADV
admet-514	75	28	lysosomes	lysosome	NOUN
admet-514	75	29	)	)	PUNCT
admet-514	75	30	.	.	PUNCT
admet-514	76	1	after	after	ADP
admet-514	76	2	24	24	NUM
admet-514	76	3	hours	hour	NOUN
admet-514	76	4	no	no	DET
admet-514	76	5	distribution	distribution	NOUN
admet-514	76	6	change	change	NOUN
admet-514	76	7	was	be	AUX
admet-514	76	8	observed	observe	VERB
admet-514	76	9	,	,	PUNCT
admet-514	76	10	although	although	SCONJ
admet-514	76	11	the	the	DET
admet-514	76	12	absolute	absolute	ADJ
admet-514	76	13	amount	amount	NOUN
admet-514	76	14	of	of	ADP
admet-514	76	15	sunitinib	sunitinib	NOUN
admet-514	76	16	decreased	decrease	VERB
admet-514	76	17	3.9	3.9	NUM
admet-514	76	18	fold	fold	NOUN
admet-514	76	19	(	(	PUNCT
admet-514	76	20	tables	table	NOUN
admet-514	76	21	1	1	NUM
admet-514	76	22	and	and	CCONJ
admet-514	76	23	2	2	NUM
admet-514	76	24	;	;	PUNCT
admet-514	76	25	figure	figure	NOUN
admet-514	76	26	1	1	NUM
admet-514	76	27	)	)	PUNCT
admet-514	76	28	.	.	PUNCT
admet-514	77	1	table	table	NOUN
admet-514	77	2	1	1	NUM
admet-514	77	3	.	.	PUNCT
admet-514	77	4	subcellular	subcellular	ADJ
admet-514	77	5	distribution	distribution	NOUN
admet-514	77	6	of	of	ADP
admet-514	77	7	6	6	NUM
admet-514	77	8	tyrosine	tyrosine	NOUN
admet-514	77	9	kinase	kinase	NOUN
admet-514	77	10	inhibitors	inhibitor	NOUN
admet-514	77	11	time	time	NOUN
admet-514	77	12	(	(	PUNCT
admet-514	77	13	hours	hour	NOUN
admet-514	77	14	)	)	PUNCT
admet-514	77	15	sunitinib	sunitinib	NOUN
admet-514	77	16	crizotinib	crizotinib	VERB
admet-514	77	17	erlotinib	erlotinib	NOUN
admet-514	77	18	gefitinib	gefitinib	NOUN
admet-514	77	19	sorafenib	sorafenib	VERB
admet-514	77	20	dasatinib	dasatinib	PROPN
admet-514	77	21	cytosolic	cytosolic	ADJ
admet-514	77	22	fraction	fraction	NOUN
admet-514	77	23	(	(	PUNCT
admet-514	77	24	1	1	NUM
admet-514	77	25	)	)	PUNCT
admet-514	77	26	2	2	NUM
admet-514	77	27	57.5	57.5	NUM
admet-514	77	28	58.3	58.3	NUM
admet-514	77	29	10.1	10.1	NUM
admet-514	77	30	38.8	38.8	NUM
admet-514	77	31	15.3	15.3	NUM
admet-514	77	32	100	100	NUM
admet-514	77	33	24	24	NUM
admet-514	77	34	56.6	56.6	NUM
admet-514	77	35	41.7	41.7	NUM
admet-514	77	36	0.0	0.0	NUM
admet-514	77	37	56.3	56.3	NUM
admet-514	77	38	0.0	0.0	NUM
admet-514	77	39	55.6	55.6	NUM
admet-514	77	40	membrane	membrane	NOUN
admet-514	77	41	fraction	fraction	NOUN
admet-514	77	42	(	(	PUNCT
admet-514	77	43	2	2	NUM
admet-514	77	44	)	)	PUNCT
admet-514	77	45	2	2	NUM
admet-514	77	46	42.1	42.1	NUM
admet-514	77	47	41.7	41.7	NUM
admet-514	77	48	7.1	7.1	NUM
admet-514	77	49	44.4	44.4	NUM
admet-514	77	50	84.7	84.7	NUM
admet-514	77	51	0.0	0.0	NUM
admet-514	77	52	24	24	NUM
admet-514	77	53	40.2	40.2	NUM
admet-514	77	54	56.4	56.4	NUM
admet-514	77	55	0.0	0.0	NUM
admet-514	77	56	30.0	30.0	NUM
admet-514	77	57	60.4	60.4	NUM
admet-514	77	58	27.9	27.9	NUM
admet-514	77	59	organelles	organelle	NOUN
admet-514	77	60	fraction	fraction	NOUN
admet-514	77	61	(	(	PUNCT
admet-514	77	62	3	3	NUM
admet-514	77	63	)	)	PUNCT
admet-514	77	64	2	2	NUM
admet-514	77	65	0.4	0.4	NUM
admet-514	77	66	0.0	0.0	NUM
admet-514	77	67	3.6	3.6	NUM
admet-514	77	68	16.8	16.8	NUM
admet-514	77	69	0.0	0.0	NUM
admet-514	77	70	0.0	0.0	NUM
admet-514	77	71	24	24	NUM
admet-514	77	72	2.7	2.7	NUM
admet-514	77	73	2.0	2.0	NUM
admet-514	77	74	0.0	0.0	NUM
admet-514	77	75	11.0	11.0	NUM
admet-514	77	76	13.9	13.9	NUM
admet-514	77	77	0.0	0.0	NUM
admet-514	77	78	cytoskeletal	cytoskeletal	ADJ
admet-514	77	79	fraction	fraction	NOUN
admet-514	77	80	(	(	PUNCT
admet-514	77	81	4	4	NUM
admet-514	77	82	)	)	PUNCT
admet-514	77	83	2	2	NUM
admet-514	77	84	0.0	0.0	NUM
admet-514	77	85	0.0	0.0	NUM
admet-514	77	86	79.2	79.2	NUM
admet-514	77	87	0.0	0.0	NUM
admet-514	77	88	0.0	0.0	NUM
admet-514	77	89	0.0	0.0	NUM
admet-514	77	90	24	24	NUM
admet-514	77	91	0.5	0.5	NUM
admet-514	77	92	0.0	0.0	NUM
admet-514	77	93	100.0	100.0	NUM
admet-514	77	94	2.8	2.8	NUM
admet-514	77	95	25.7	25.7	NUM
admet-514	77	96	16.5	16.5	NUM
admet-514	77	97	values	value	NOUN
admet-514	77	98	are	be	AUX
admet-514	77	99	percentages	percentage	NOUN
admet-514	77	100	(	(	PUNCT
admet-514	77	101	%	%	INTJ
admet-514	77	102	)	)	PUNCT
admet-514	77	103	of	of	ADP
admet-514	77	104	total	total	ADJ
admet-514	77	105	cellular	cellular	ADJ
admet-514	77	106	accumulation	accumulation	NOUN
admet-514	77	107	after	after	SCONJ
admet-514	77	108	2	2	NUM
admet-514	77	109	and	and	CCONJ
admet-514	77	110	24	24	NUM
admet-514	77	111	hr	hr	NOUN
admet-514	77	112	of	of	ADP
admet-514	77	113	analyses	analysis	NOUN
admet-514	77	114	performed	perform	VERB
admet-514	77	115	in	in	ADP
admet-514	77	116	duplicate	duplicate	ADJ
admet-514	77	117	table	table	NOUN
admet-514	77	118	2	2	NUM
admet-514	77	119	.	.	NOUN
admet-514	77	120	time	time	NOUN
admet-514	77	121	dependence	dependence	NOUN
admet-514	77	122	of	of	ADP
admet-514	77	123	total	total	ADJ
admet-514	77	124	cellular	cellular	ADJ
admet-514	77	125	accumulation	accumulation	NOUN
admet-514	77	126	of	of	ADP
admet-514	77	127	6	6	NUM
admet-514	77	128	tkis	tkis	NOUN
admet-514	77	129	drug	drug	NOUN
admet-514	77	130	total	total	ADJ
admet-514	77	131	cellular	cellular	ADJ
admet-514	77	132	accumulation	accumulation	NOUN
admet-514	77	133	(	(	PUNCT
admet-514	77	134	fmol	fmol	NOUN
admet-514	77	135	/	/	SYM
admet-514	77	136	mg	mg	PROPN
admet-514	77	137	protein	protein	NOUN
admet-514	77	138	)	)	PUNCT
admet-514	77	139	2	2	NUM
admet-514	77	140	hours	hour	NOUN
admet-514	77	141	24	24	NUM
admet-514	77	142	hours	hour	NOUN
admet-514	77	143	sunitinib	sunitinib	NOUN
admet-514	77	144	25692.8	25692.8	NUM
admet-514	77	145	4218.4	4218.4	NUM
admet-514	77	146	crizotinib	crizotinib	NOUN
admet-514	77	147	5581.4	5581.4	NUM
admet-514	77	148	19867.6	19867.6	NUM
admet-514	77	149	erlotinib	erlotinib	NOUN
admet-514	77	150	314.9	314.9	NUM
admet-514	77	151	88.4	88.4	NUM
admet-514	77	152	gefitinib	gefitinib	NOUN
admet-514	77	153	1572.8	1572.8	NUM
admet-514	77	154	462.9	462.9	NUM
admet-514	77	155	sorafenib	sorafenib	NOUN
admet-514	77	156	2056.2	2056.2	NUM
admet-514	77	157	267.1	267.1	NUM
admet-514	77	158	dasatinib	dasatinib	NOUN
admet-514	77	159	244.4	244.4	NUM
admet-514	77	160	97.1	97.1	NUM
admet-514	77	161	values	value	NOUN
admet-514	77	162	are	be	AUX
admet-514	77	163	means	mean	NOUN
admet-514	77	164	of	of	ADP
admet-514	77	165	analyses	analysis	NOUN
admet-514	77	166	performed	perform	VERB
admet-514	77	167	in	in	ADP
admet-514	77	168	duplicate	duplicate	NOUN
admet-514	77	169	.	.	PUNCT
admet-514	78	1	sem	sem	PROPN
admet-514	78	2	was	be	AUX
admet-514	78	3	below	below	ADP
admet-514	78	4	15	15	NUM
admet-514	78	5	%	%	NOUN
admet-514	78	6	crizotinib	crizotinib	NOUN
admet-514	78	7	showed	show	VERB
admet-514	78	8	a	a	DET
admet-514	78	9	similar	similar	ADJ
admet-514	78	10	distribution	distribution	NOUN
admet-514	78	11	pattern	pattern	NOUN
admet-514	78	12	compared	compare	VERB
admet-514	78	13	to	to	ADP
admet-514	78	14	sunitinib	sunitinib	NOUN
admet-514	78	15	.	.	PUNCT
admet-514	79	1	after	after	ADP
admet-514	79	2	2	2	NUM
admet-514	79	3	hours	hour	NOUN
admet-514	79	4	it	it	PRON
admet-514	79	5	was	be	AUX
admet-514	79	6	highly	highly	ADV
admet-514	79	7	distributed	distribute	VERB
admet-514	79	8	into	into	ADP
admet-514	79	9	the	the	DET
admet-514	79	10	cytosol	cytosol	NOUN
admet-514	79	11	(	(	PUNCT
admet-514	79	12	58.3	58.3	NUM
admet-514	79	13	%	%	NOUN
admet-514	79	14	)	)	PUNCT
admet-514	79	15	,	,	PUNCT
admet-514	79	16	membranes	membrane	NOUN
admet-514	79	17	and	and	CCONJ
admet-514	79	18	membrane	membrane	NOUN
admet-514	79	19	organelles	organelle	NOUN
admet-514	79	20	(	(	PUNCT
admet-514	79	21	41.7	41.7	NUM
admet-514	79	22	%	%	NOUN
admet-514	79	23	)	)	PUNCT
admet-514	79	24	.	.	PUNCT
admet-514	80	1	although	although	SCONJ
admet-514	80	2	the	the	DET
admet-514	80	3	distribution	distribution	NOUN
admet-514	80	4	remained	remain	VERB
admet-514	80	5	consistent	consistent	ADJ
admet-514	80	6	after	after	ADP
admet-514	80	7	24	24	NUM
admet-514	80	8	hours	hour	NOUN
admet-514	80	9	a	a	DET
admet-514	80	10	4.5	4.5	NUM
admet-514	80	11	-	-	ADJ
admet-514	80	12	fold	fold	ADJ
admet-514	80	13	increase	increase	NOUN
admet-514	80	14	in	in	ADP
admet-514	80	15	accumulation	accumulation	NOUN
admet-514	80	16	was	be	AUX
admet-514	80	17	observed	observe	VERB
admet-514	80	18	.	.	PUNCT
admet-514	81	1	one	one	NUM
admet-514	81	2	tki	tki	NOUN
admet-514	81	3	,	,	PUNCT
admet-514	81	4	which	which	PRON
admet-514	81	5	showed	show	VERB
admet-514	81	6	a	a	DET
admet-514	81	7	totally	totally	ADV
admet-514	81	8	different	different	ADJ
admet-514	81	9	distribution	distribution	NOUN
admet-514	81	10	pattern	pattern	NOUN
admet-514	81	11	,	,	PUNCT
admet-514	81	12	was	be	AUX
admet-514	81	13	erlotinib	erlotinib	NOUN
admet-514	81	14	(	(	PUNCT
admet-514	81	15	table	table	NOUN
admet-514	81	16	1	1	NUM
admet-514	81	17	)	)	PUNCT
admet-514	81	18	.	.	PUNCT
admet-514	82	1	a	a	DET
admet-514	82	2	distribution	distribution	NOUN
admet-514	82	3	of	of	ADP
admet-514	82	4	erlotinib	erlotinib	NOUN
admet-514	82	5	throughout	throughout	ADP
admet-514	82	6	the	the	DET
admet-514	82	7	whole	whole	ADJ
admet-514	82	8	cell	cell	NOUN
admet-514	82	9	was	be	AUX
admet-514	82	10	observed	observe	VERB
admet-514	82	11	after	after	ADP
admet-514	82	12	2	2	NUM
admet-514	82	13	hours	hour	NOUN
admet-514	82	14	exposure	exposure	NOUN
admet-514	82	15	,	,	PUNCT
admet-514	82	16	although	although	SCONJ
admet-514	82	17	most	most	ADJ
admet-514	82	18	of	of	ADP
admet-514	82	19	the	the	DET
admet-514	82	20	accumulated	accumulate	VERB
admet-514	82	21	erlotinib	erlotinib	NOUN
admet-514	82	22	was	be	AUX
admet-514	82	23	located	locate	VERB
admet-514	82	24	in	in	ADP
admet-514	82	25	cytoskeleton	cytoskeleton	NOUN
admet-514	82	26	components	component	NOUN
admet-514	82	27	.	.	PUNCT
admet-514	83	1	after	after	ADP
admet-514	83	2	24	24	NUM
admet-514	83	3	hours	hour	NOUN
admet-514	83	4	total	total	ADJ
admet-514	83	5	accumulation	accumulation	NOUN
admet-514	83	6	decreased	decrease	VERB
admet-514	83	7	20	20	NUM
admet-514	83	8	-	-	NUM
admet-514	83	9	fold	fold	VERB
admet-514	83	10	and	and	CCONJ
admet-514	83	11	was	be	AUX
admet-514	83	12	located	locate	VERB
admet-514	83	13	solely	solely	ADV
admet-514	83	14	in	in	ADP
admet-514	83	15	the	the	DET
admet-514	83	16	cytoskeleton	cytoskeleton	NOUN
admet-514	83	17	.	.	PUNCT
admet-514	84	1	gefitinib	gefitinib	NOUN
admet-514	84	2	,	,	PUNCT
admet-514	84	3	which	which	PRON
admet-514	84	4	also	also	ADV
admet-514	84	5	inhibits	inhibit	VERB
admet-514	84	6	egfr	egfr	NOUN
admet-514	84	7	showed	show	VERB
admet-514	84	8	a	a	DET
admet-514	84	9	completely	completely	ADV
admet-514	84	10	different	different	ADJ
admet-514	84	11	pattern	pattern	NOUN
admet-514	84	12	both	both	CCONJ
admet-514	84	13	after	after	ADP
admet-514	84	14	2	2	NUM
admet-514	84	15	and	and	CCONJ
admet-514	84	16	24	24	NUM
admet-514	84	17	hours	hour	NOUN
admet-514	84	18	exposure	exposure	NOUN
admet-514	84	19	(	(	PUNCT
admet-514	84	20	table	table	NOUN
admet-514	84	21	1	1	NUM
admet-514	84	22	)	)	PUNCT
admet-514	84	23	.	.	PUNCT
admet-514	85	1	after	after	SCONJ
admet-514	85	2	2	2	NUM
admet-514	85	3	hours	hour	NOUN
admet-514	85	4	gefitinib	gefitinib	NOUN
admet-514	85	5	was	be	AUX
admet-514	85	6	located	locate	VERB
admet-514	85	7	in	in	ADP
admet-514	85	8	the	the	DET
admet-514	85	9	cytosol	cytosol	NOUN
admet-514	85	10	(	(	PUNCT
admet-514	85	11	38.8	38.8	NUM
admet-514	85	12	%	%	NOUN
admet-514	85	13	)	)	PUNCT
admet-514	85	14	,	,	PUNCT
admet-514	85	15	membranes	membrane	NOUN
admet-514	85	16	and	and	CCONJ
admet-514	85	17	membrane	membrane	NOUN
admet-514	85	18	richard	richard	PROPN
admet-514	85	19	honeywell	honeywell	PROPN
admet-514	85	20	et	et	PROPN
admet-514	85	21	al	al	PROPN
admet-514	85	22	.	.	PROPN
admet-514	85	23	admet	admet	PROPN
admet-514	85	24	&	&	CCONJ
admet-514	85	25	dmpk	dmpk	PROPN
admet-514	85	26	6(3	6(3	PROPN
admet-514	85	27	)	)	PUNCT
admet-514	85	28	(	(	PUNCT
admet-514	85	29	2018	2018	NUM
admet-514	85	30	)	)	PUNCT
admet-514	85	31	258	258	NUM
admet-514	85	32	-	-	SYM
admet-514	85	33	266	266	NUM
admet-514	85	34	262	262	NUM
admet-514	85	35	organelles	organelle	NOUN
admet-514	85	36	(	(	PUNCT
admet-514	85	37	44.4	44.4	NUM
admet-514	85	38	%	%	NOUN
admet-514	85	39	)	)	PUNCT
admet-514	85	40	and	and	CCONJ
admet-514	85	41	nuclear	nuclear	ADJ
admet-514	85	42	proteins	protein	NOUN
admet-514	85	43	(	(	PUNCT
admet-514	85	44	16.8	16.8	NUM
admet-514	85	45	%	%	NOUN
admet-514	85	46	)	)	PUNCT
admet-514	85	47	,	,	PUNCT
admet-514	85	48	but	but	CCONJ
admet-514	85	49	not	not	PART
admet-514	85	50	in	in	ADP
admet-514	85	51	the	the	DET
admet-514	85	52	cytoskeleton	cytoskeleton	NOUN
admet-514	85	53	as	as	ADP
admet-514	85	54	erlotinib	erlotinib	NOUN
admet-514	85	55	,	,	PUNCT
admet-514	85	56	which	which	PRON
admet-514	85	57	hardly	hardly	ADV
admet-514	85	58	changed	change	VERB
admet-514	85	59	after	after	ADP
admet-514	85	60	24	24	NUM
admet-514	85	61	hours	hour	NOUN
admet-514	85	62	.	.	PUNCT
admet-514	86	1	5	5	NUM
admet-514	86	2	7	7	NUM
admet-514	86	3	.	.	PUNCT
admet-514	87	1	5	5	NUM
admet-514	87	2	0	0	NUM
admet-514	87	3	%	%	NOUN
admet-514	87	4	c	c	NOUN
admet-514	88	1	y	y	PROPN
admet-514	88	2	t	t	NOUN
admet-514	89	1	o	o	X
admet-514	89	2	s	s	X
admet-514	89	3	o	o	X
admet-514	89	4	le	le	ADP
admet-514	89	5	4	4	NUM
admet-514	89	6	2	2	NUM
admet-514	89	7	.	.	PUNCT
admet-514	89	8	1	1	NUM
admet-514	89	9	0	0	NUM
admet-514	89	10	%	%	NOUN
admet-514	90	1	c	c	NOUN
admet-514	90	2	e	e	NOUN
admet-514	90	3	l	l	NOUN
admet-514	90	4	l	l	X
admet-514	90	5	u	u	X
admet-514	90	6	l	l	NOUN
admet-514	90	7	a	a	DET
admet-514	90	8	r	r	NOUN
admet-514	90	9	m	m	VERB
admet-514	90	10	e	e	NOUN
admet-514	90	11	m	m	PROPN
admet-514	90	12	b	b	NOUN
admet-514	90	13	r	r	NOUN
admet-514	90	14	a	a	DET
admet-514	90	15	n	n	NOUN
admet-514	90	16	e	e	ADP
admet-514	90	17	2	2	NUM
admet-514	90	18	h	h	NOUN
admet-514	90	19	r	r	NOUN
admet-514	90	20	s	s	NOUN
admet-514	90	21	u	u	NOUN
admet-514	90	22	n	n	CCONJ
admet-514	91	1	i	i	PRON
admet-514	91	2	t	t	VERB
admet-514	91	3	i	i	PRON
admet-514	92	1	n	n	PROPN
admet-514	93	1	i	i	NOUN
admet-514	93	2	b	b	X
admet-514	93	3	e	e	NOUN
admet-514	93	4	x	x	X
admet-514	94	1	p	p	NOUN
admet-514	94	2	o	o	X
admet-514	94	3	s	s	X
admet-514	94	4	u	u	NOUN
admet-514	94	5	r	r	NOUN
admet-514	94	6	e	e	NOUN
admet-514	94	7	0	0	NUM
admet-514	94	8	.	.	PUNCT
admet-514	95	1	4	4	NUM
admet-514	95	2	0	0	NUM
admet-514	95	3	%	%	NOUN
admet-514	95	4	m	m	VERB
admet-514	96	1	i	i	PRON
admet-514	96	2	t	t	X
admet-514	97	1	o	o	X
admet-514	97	2	c	c	NOUN
admet-514	98	1	h	h	NOUN
admet-514	98	2	o	o	NOUN
admet-514	99	1	n	n	INTJ
admet-514	99	2	d	d	NOUN
admet-514	99	3	r	r	NOUN
admet-514	100	1	i	i	PRON
admet-514	101	1	a	a	PRON
admet-514	101	2	a	a	DET
admet-514	101	3	n	n	NOUN
admet-514	101	4	d	d	PROPN
admet-514	101	5	n	n	CCONJ
admet-514	101	6	u	u	NOUN
admet-514	101	7	c	c	X
admet-514	101	8	le	le	ADP
admet-514	101	9	u	u	NOUN
admet-514	101	10	s	s	PROPN
admet-514	101	11	2	2	NUM
admet-514	101	12	4	4	NUM
admet-514	101	13	s	s	NOUN
admet-514	101	14	u	u	NOUN
admet-514	101	15	n	n	CCONJ
admet-514	102	1	i	i	PRON
admet-514	103	1	t	t	VERB
admet-514	104	1	i	i	PRON
admet-514	105	1	n	n	PROPN
admet-514	106	1	i	i	PRON
admet-514	107	1	b	b	NOUN
admet-514	107	2	h	h	NOUN
admet-514	107	3	o	o	X
admet-514	107	4	u	u	NOUN
admet-514	107	5	r	r	NOUN
admet-514	107	6	e	e	NOUN
admet-514	107	7	x	x	X
admet-514	108	1	p	p	X
admet-514	108	2	o	o	X
admet-514	108	3	s	s	X
admet-514	108	4	u	u	NOUN
admet-514	108	5	r	r	NOUN
admet-514	108	6	e	e	NOUN
admet-514	108	7	4	4	NUM
admet-514	108	8	0	0	NUM
admet-514	108	9	.	.	PUNCT
admet-514	109	1	2	2	NUM
admet-514	109	2	0	0	NUM
admet-514	109	3	%	%	NOUN
admet-514	109	4	c	c	NOUN
admet-514	109	5	e	e	NOUN
admet-514	109	6	l	l	NOUN
admet-514	109	7	l	l	X
admet-514	109	8	u	u	X
admet-514	109	9	l	l	NOUN
admet-514	109	10	a	a	DET
admet-514	109	11	r	r	NOUN
admet-514	109	12	m	m	VERB
admet-514	109	13	e	e	NOUN
admet-514	109	14	m	m	PROPN
admet-514	109	15	b	b	NOUN
admet-514	109	16	r	r	NOUN
admet-514	109	17	a	a	DET
admet-514	109	18	n	n	NOUN
admet-514	109	19	e	e	NOUN
admet-514	109	20	2	2	NUM
admet-514	109	21	.	.	PUNCT
admet-514	109	22	7	7	NUM
admet-514	109	23	0	0	NUM
admet-514	109	24	%	%	NOUN
admet-514	109	25	m	m	VERB
admet-514	110	1	i	i	PRON
admet-514	110	2	t	t	X
admet-514	111	1	o	o	X
admet-514	111	2	c	c	NOUN
admet-514	112	1	h	h	NOUN
admet-514	112	2	o	o	NOUN
admet-514	113	1	n	n	INTJ
admet-514	113	2	d	d	NOUN
admet-514	113	3	r	r	NOUN
admet-514	114	1	i	i	PRON
admet-514	115	1	a	a	PRON
admet-514	115	2	a	a	DET
admet-514	115	3	n	n	NOUN
admet-514	115	4	d	d	PROPN
admet-514	115	5	n	n	CCONJ
admet-514	115	6	u	u	NOUN
admet-514	115	7	c	c	X
admet-514	115	8	le	le	ADP
admet-514	115	9	u	u	NOUN
admet-514	115	10	s	s	PROPN
admet-514	115	11	5	5	NUM
admet-514	115	12	6	6	NUM
admet-514	115	13	.	.	PUNCT
admet-514	115	14	6	6	NUM
admet-514	115	15	0	0	NUM
admet-514	115	16	%	%	NOUN
admet-514	116	1	c	c	NOUN
admet-514	116	2	y	y	PROPN
admet-514	116	3	t	t	NOUN
admet-514	117	1	o	o	X
admet-514	117	2	s	s	X
admet-514	117	3	o	o	X
admet-514	117	4	le	le	ADP
admet-514	117	5	1	1	NUM
admet-514	117	6	0	0	NUM
admet-514	117	7	0	0	NUM
admet-514	117	8	.	.	PUNCT
admet-514	118	1	0	0	NUM
admet-514	118	2	0	0	NUM
admet-514	118	3	%	%	NOUN
admet-514	119	1	c	c	NOUN
admet-514	119	2	y	y	PROPN
admet-514	119	3	t	t	NOUN
admet-514	120	1	o	o	X
admet-514	120	2	s	s	X
admet-514	120	3	o	o	X
admet-514	120	4	le	le	X
admet-514	120	5	2	2	NUM
admet-514	120	6	h	h	NOUN
admet-514	120	7	r	r	NOUN
admet-514	120	8	d	d	PROPN
admet-514	120	9	a	a	DET
admet-514	120	10	s	s	NOUN
admet-514	120	11	a	a	DET
admet-514	120	12	t	t	NOUN
admet-514	121	1	i	i	PRON
admet-514	121	2	n	n	NOUN
admet-514	121	3	i	i	NOUN
admet-514	121	4	b	b	X
admet-514	121	5	e	e	NOUN
admet-514	121	6	x	x	X
admet-514	122	1	p	p	NOUN
admet-514	122	2	o	o	X
admet-514	122	3	s	s	X
admet-514	122	4	u	u	NOUN
admet-514	122	5	r	r	NOUN
admet-514	122	6	e	e	NOUN
admet-514	122	7	2	2	NUM
admet-514	122	8	4	4	NUM
admet-514	122	9	h	h	NOUN
admet-514	122	10	o	o	NOUN
admet-514	122	11	u	u	NOUN
admet-514	122	12	r	r	NOUN
admet-514	122	13	d	d	PROPN
admet-514	122	14	a	a	PRON
admet-514	122	15	s	s	NOUN
admet-514	122	16	a	a	DET
admet-514	122	17	t	t	NOUN
admet-514	123	1	i	i	PRON
admet-514	124	1	n	n	NOUN
admet-514	125	1	i	i	NOUN
admet-514	125	2	b	b	X
admet-514	125	3	e	e	NOUN
admet-514	125	4	x	x	X
admet-514	126	1	p	p	NOUN
admet-514	126	2	o	o	X
admet-514	126	3	s	s	X
admet-514	126	4	u	u	NOUN
admet-514	126	5	r	r	NOUN
admet-514	126	6	e	e	NOUN
admet-514	126	7	2	2	NUM
admet-514	126	8	7	7	NUM
admet-514	126	9	.	.	PUNCT
admet-514	127	1	9	9	NUM
admet-514	127	2	0	0	NUM
admet-514	127	3	%	%	NOUN
admet-514	127	4	c	c	NOUN
admet-514	127	5	e	e	NOUN
admet-514	127	6	l	l	NOUN
admet-514	127	7	l	l	X
admet-514	127	8	u	u	X
admet-514	127	9	l	l	NOUN
admet-514	127	10	a	a	DET
admet-514	127	11	r	r	NOUN
admet-514	127	12	m	m	VERB
admet-514	127	13	e	e	NOUN
admet-514	127	14	m	m	PROPN
admet-514	127	15	b	b	NOUN
admet-514	127	16	r	r	NOUN
admet-514	127	17	a	a	DET
admet-514	127	18	n	n	NOUN
admet-514	127	19	e	e	NOUN
admet-514	127	20	1	1	NUM
admet-514	127	21	6	6	NUM
admet-514	127	22	.	.	PUNCT
admet-514	128	1	5	5	NUM
admet-514	128	2	0	0	NUM
admet-514	128	3	%	%	NOUN
admet-514	128	4	c	c	NOUN
admet-514	129	1	y	y	PROPN
admet-514	129	2	t	t	NOUN
admet-514	130	1	o	o	X
admet-514	130	2	s	s	X
admet-514	130	3	k	k	X
admet-514	130	4	e	e	PROPN
admet-514	130	5	la	la	PROPN
admet-514	130	6	t	t	PROPN
admet-514	130	7	a	a	DET
admet-514	130	8	l	l	NOUN
admet-514	130	9	5	5	NUM
admet-514	130	10	5	5	NUM
admet-514	130	11	.	.	PUNCT
admet-514	131	1	6	6	NUM
admet-514	131	2	0	0	NUM
admet-514	131	3	%	%	NOUN
admet-514	131	4	c	c	NOUN
admet-514	132	1	y	y	PROPN
admet-514	132	2	t	t	NOUN
admet-514	133	1	o	o	X
admet-514	133	2	s	s	X
admet-514	133	3	o	o	X
admet-514	133	4	le	le	X
admet-514	133	5	figure	figure	NOUN
admet-514	133	6	1	1	NUM
admet-514	133	7	.	.	PUNCT
admet-514	133	8	pie	pie	NOUN
admet-514	133	9	chart	chart	NOUN
admet-514	133	10	of	of	ADP
admet-514	133	11	the	the	DET
admet-514	133	12	cellular	cellular	ADJ
admet-514	133	13	distribution	distribution	NOUN
admet-514	133	14	of	of	ADP
admet-514	133	15	sunitinib	sunitinib	NOUN
admet-514	133	16	and	and	CCONJ
admet-514	133	17	dasatinib	dasatinib	NOUN
admet-514	133	18	after	after	ADP
admet-514	133	19	2	2	NUM
admet-514	133	20	and	and	CCONJ
admet-514	133	21	24	24	NUM
admet-514	133	22	hours	hour	NOUN
admet-514	133	23	exposure	exposure	NOUN
admet-514	133	24	to	to	ADP
admet-514	133	25	10	10	NUM
admet-514	133	26	μm	μm	NOUN
admet-514	133	27	of	of	ADP
admet-514	133	28	either	either	DET
admet-514	133	29	sunitinib	sunitinib	NOUN
admet-514	133	30	or	or	CCONJ
admet-514	133	31	dasatinib	dasatinib	NOUN
admet-514	133	32	respectively	respectively	ADV
admet-514	133	33	both	both	DET
admet-514	133	34	sorafenib	sorafenib	NOUN
admet-514	133	35	and	and	CCONJ
admet-514	133	36	dasatinib	dasatinib	NOUN
admet-514	133	37	do	do	AUX
admet-514	133	38	not	not	PART
admet-514	133	39	correspond	correspond	VERB
admet-514	133	40	with	with	ADP
admet-514	133	41	the	the	DET
admet-514	133	42	other	other	ADJ
admet-514	133	43	tkis	tkis	NOUN
admet-514	133	44	and	and	CCONJ
admet-514	133	45	each	each	DET
admet-514	133	46	other	other	ADJ
admet-514	133	47	’s	’s	PART
admet-514	133	48	distribution	distribution	NOUN
admet-514	133	49	pattern	pattern	NOUN
admet-514	133	50	(	(	PUNCT
admet-514	133	51	table	table	NOUN
admet-514	133	52	1	1	NUM
admet-514	133	53	;	;	PUNCT
admet-514	133	54	figure	figure	NOUN
admet-514	133	55	1	1	NUM
admet-514	133	56	)	)	PUNCT
admet-514	133	57	.	.	PUNCT
admet-514	134	1	after	after	ADP
admet-514	134	2	two	two	NUM
admet-514	134	3	hours	hour	NOUN
admet-514	134	4	exposure	exposure	NOUN
admet-514	134	5	,	,	PUNCT
admet-514	134	6	sorafenib	sorafenib	PROPN
admet-514	134	7	is	be	AUX
admet-514	134	8	solely	solely	ADV
admet-514	134	9	distributed	distribute	VERB
admet-514	134	10	in	in	ADP
admet-514	134	11	the	the	DET
admet-514	134	12	membranes	membrane	NOUN
admet-514	134	13	,	,	PUNCT
admet-514	134	14	membrane	membrane	ADJ
admet-514	134	15	organelles	organelle	NOUN
admet-514	134	16	(	(	PUNCT
admet-514	134	17	84.7	84.7	NUM
admet-514	134	18	%	%	NOUN
admet-514	134	19	)	)	PUNCT
admet-514	134	20	and	and	CCONJ
admet-514	134	21	cytosol	cytosol	NOUN
admet-514	134	22	(	(	PUNCT
admet-514	134	23	15.3	15.3	NUM
admet-514	134	24	%	%	NOUN
admet-514	134	25	)	)	PUNCT
admet-514	134	26	.	.	PUNCT
admet-514	135	1	after	after	SCONJ
admet-514	135	2	24	24	NUM
admet-514	135	3	hours	hour	NOUN
admet-514	135	4	accumulation	accumulation	NOUN
admet-514	135	5	decreased	decrease	VERB
admet-514	135	6	9.9	9.9	NUM
admet-514	135	7	-	-	NUM
admet-514	135	8	fold	fold	ADJ
admet-514	135	9	(	(	PUNCT
admet-514	135	10	table	table	NOUN
admet-514	135	11	2	2	NUM
admet-514	135	12	)	)	PUNCT
admet-514	135	13	and	and	CCONJ
admet-514	135	14	sorafenib	sorafenib	NOUN
admet-514	135	15	distribution	distribution	NOUN
admet-514	135	16	shifted	shift	VERB
admet-514	135	17	to	to	ADP
admet-514	135	18	membranes	membrane	NOUN
admet-514	135	19	and	and	CCONJ
admet-514	135	20	membrane	membrane	NOUN
admet-514	135	21	organelles	organelle	NOUN
admet-514	135	22	(	(	PUNCT
admet-514	135	23	60.4	60.4	NUM
admet-514	135	24	%	%	NOUN
admet-514	135	25	)	)	PUNCT
admet-514	135	26	,	,	PUNCT
admet-514	135	27	cytoskeleton	cytoskeleton	PROPN
admet-514	135	28	(	(	PUNCT
admet-514	135	29	25.7	25.7	NUM
admet-514	135	30	%	%	NOUN
admet-514	135	31	)	)	PUNCT
admet-514	135	32	and	and	CCONJ
admet-514	135	33	nuclear	nuclear	ADJ
admet-514	135	34	proteins	protein	NOUN
admet-514	135	35	(	(	PUNCT
admet-514	135	36	13.9	13.9	NUM
admet-514	135	37	%	%	NOUN
admet-514	135	38	)	)	PUNCT
admet-514	135	39	.	.	PUNCT
admet-514	136	1	accumulated	accumulate	VERB
admet-514	136	2	dasatinib	dasatinib	NOUN
admet-514	136	3	was	be	AUX
admet-514	136	4	located	locate	VERB
admet-514	136	5	solely	solely	ADV
admet-514	136	6	in	in	ADP
admet-514	136	7	the	the	DET
admet-514	136	8	cytosol	cytosol	NOUN
admet-514	136	9	after	after	ADP
admet-514	136	10	two	two	NUM
admet-514	136	11	hours	hour	NOUN
admet-514	136	12	exposure	exposure	NOUN
admet-514	136	13	(	(	PUNCT
admet-514	136	14	figure	figure	NOUN
admet-514	136	15	1	1	NUM
admet-514	136	16	;	;	PUNCT
admet-514	136	17	table	table	NOUN
admet-514	136	18	1	1	NUM
admet-514	136	19	)	)	PUNCT
admet-514	136	20	.	.	PUNCT
admet-514	137	1	admet	admet	PROPN
admet-514	137	2	&	&	CCONJ
admet-514	137	3	dmpk	dmpk	PROPN
admet-514	137	4	6(3	6(3	PROPN
admet-514	137	5	)	)	PUNCT
admet-514	137	6	(	(	PUNCT
admet-514	137	7	2018	2018	NUM
admet-514	137	8	)	)	PUNCT
admet-514	137	9	258	258	NUM
admet-514	137	10	-	-	PUNCT
admet-514	137	11	266	266	NUM
admet-514	137	12	subcellular	subcellular	ADJ
admet-514	137	13	localization	localization	NOUN
admet-514	137	14	of	of	ADP
admet-514	137	15	several	several	ADJ
admet-514	137	16	structurally	structurally	ADV
admet-514	137	17	different	different	ADJ
admet-514	137	18	tkis	tkis	PROPN
admet-514	137	19	doi	doi	NOUN
admet-514	137	20	:	:	PUNCT
admet-514	137	21	10.5599	10.5599	NUM
admet-514	137	22	/	/	SYM
admet-514	137	23	admet.514	admet.514	PROPN
admet-514	137	24	263	263	NUM
admet-514	137	25	similar	similar	ADJ
admet-514	137	26	to	to	ADP
admet-514	137	27	sorafenib	sorafenib	NOUN
admet-514	137	28	,	,	PUNCT
admet-514	137	29	the	the	DET
admet-514	137	30	distribution	distribution	NOUN
admet-514	137	31	of	of	ADP
admet-514	137	32	dasatinib	dasatinib	NOUN
admet-514	137	33	changed	change	VERB
admet-514	137	34	completely	completely	ADV
admet-514	137	35	after	after	ADP
admet-514	137	36	24	24	NUM
admet-514	137	37	hours	hour	NOUN
admet-514	137	38	.	.	PUNCT
admet-514	138	1	some	some	PRON
admet-514	138	2	of	of	ADP
admet-514	138	3	the	the	DET
admet-514	138	4	accumulated	accumulate	VERB
admet-514	138	5	dasatinib	dasatinib	NOUN
admet-514	138	6	shifted	shift	VERB
admet-514	138	7	from	from	ADP
admet-514	138	8	the	the	DET
admet-514	138	9	cytosol	cytosol	NOUN
admet-514	138	10	to	to	ADP
admet-514	138	11	membranes	membrane	NOUN
admet-514	138	12	and	and	CCONJ
admet-514	138	13	membrane	membrane	NOUN
admet-514	138	14	organelles	organelle	NOUN
admet-514	138	15	(	(	PUNCT
admet-514	138	16	27.9	27.9	NUM
admet-514	138	17	%	%	NOUN
admet-514	138	18	)	)	PUNCT
admet-514	138	19	and	and	CCONJ
admet-514	138	20	cytoskeleton	cytoskeleton	PROPN
admet-514	138	21	(	(	PUNCT
admet-514	138	22	16.5	16.5	NUM
admet-514	138	23	%	%	NOUN
admet-514	138	24	)	)	PUNCT
admet-514	138	25	.	.	PUNCT
admet-514	139	1	there	there	PRON
admet-514	139	2	was	be	VERB
admet-514	139	3	only	only	ADV
admet-514	139	4	a	a	DET
admet-514	139	5	small	small	ADJ
admet-514	139	6	change	change	NOUN
admet-514	139	7	in	in	ADP
admet-514	139	8	total	total	ADJ
admet-514	139	9	accumulated	accumulate	VERB
admet-514	139	10	drug	drug	NOUN
admet-514	139	11	.	.	PUNCT
admet-514	140	1	interestingly	interestingly	ADV
admet-514	140	2	the	the	DET
admet-514	140	3	total	total	ADJ
admet-514	140	4	accumulation	accumulation	NOUN
admet-514	140	5	of	of	ADP
admet-514	140	6	the	the	DET
admet-514	140	7	drugs	drug	NOUN
admet-514	140	8	was	be	AUX
admet-514	140	9	quite	quite	ADV
admet-514	140	10	different	different	ADJ
admet-514	140	11	both	both	PRON
admet-514	140	12	in	in	ADP
admet-514	140	13	the	the	DET
admet-514	140	14	amount	amount	NOUN
admet-514	140	15	and	and	CCONJ
admet-514	140	16	the	the	DET
admet-514	140	17	timecourse	timecourse	NOUN
admet-514	140	18	(	(	PUNCT
admet-514	140	19	table	table	NOUN
admet-514	140	20	2	2	NUM
admet-514	140	21	)	)	PUNCT
admet-514	140	22	.	.	PUNCT
admet-514	141	1	the	the	DET
admet-514	141	2	absolute	absolute	ADJ
admet-514	141	3	amount	amount	NOUN
admet-514	141	4	of	of	ADP
admet-514	141	5	sunitinib	sunitinib	NOUN
admet-514	141	6	accumulated	accumulate	VERB
admet-514	141	7	in	in	ADP
admet-514	141	8	the	the	DET
admet-514	141	9	cells	cell	NOUN
admet-514	141	10	decreased	decrease	VERB
admet-514	141	11	by	by	ADP
admet-514	141	12	3.9	3.9	NUM
admet-514	141	13	-	-	NOUN
admet-514	141	14	fold	fold	NOUN
admet-514	141	15	from	from	ADP
admet-514	141	16	2	2	NUM
admet-514	141	17	to	to	PART
admet-514	141	18	24	24	NUM
admet-514	141	19	hours	hour	NOUN
admet-514	141	20	which	which	PRON
admet-514	141	21	is	be	AUX
admet-514	141	22	in	in	ADP
admet-514	141	23	agreement	agreement	NOUN
admet-514	141	24	with	with	ADP
admet-514	141	25	the	the	DET
admet-514	141	26	decline	decline	NOUN
admet-514	141	27	of	of	ADP
admet-514	141	28	sunitinib	sunitinib	NOUN
admet-514	141	29	accumulation	accumulation	NOUN
admet-514	141	30	in	in	ADP
admet-514	141	31	the	the	DET
admet-514	141	32	temperature	temperature	NOUN
admet-514	141	33	dependent	dependent	ADJ
admet-514	141	34	accumulation	accumulation	NOUN
admet-514	141	35	study	study	NOUN
admet-514	141	36	after	after	ADP
admet-514	141	37	24	24	NUM
admet-514	141	38	hours	hour	NOUN
admet-514	141	39	[	[	X
admet-514	141	40	14	14	NUM
admet-514	141	41	]	]	PUNCT
admet-514	141	42	.	.	PUNCT
admet-514	142	1	in	in	ADP
admet-514	142	2	contrast	contrast	NOUN
admet-514	142	3	to	to	ADP
admet-514	142	4	sunitinib	sunitinib	NOUN
admet-514	142	5	,	,	PUNCT
admet-514	142	6	crizotinib	crizotinib	NOUN
admet-514	142	7	demonstrated	demonstrate	VERB
admet-514	142	8	a	a	DET
admet-514	142	9	4.5	4.5	NUM
admet-514	142	10	-	-	ADJ
admet-514	142	11	fold	fold	ADJ
admet-514	142	12	increase	increase	NOUN
admet-514	142	13	after	after	ADP
admet-514	142	14	24	24	NUM
admet-514	142	15	hours	hour	NOUN
admet-514	142	16	.	.	PUNCT
admet-514	143	1	accumulation	accumulation	NOUN
admet-514	143	2	of	of	ADP
admet-514	143	3	erlotinib	erlotinib	NOUN
admet-514	143	4	was	be	AUX
admet-514	143	5	very	very	ADV
admet-514	143	6	low	low	ADJ
admet-514	143	7	and	and	CCONJ
admet-514	143	8	even	even	ADV
admet-514	143	9	decreased	decrease	VERB
admet-514	143	10	after	after	ADP
admet-514	143	11	24	24	NUM
admet-514	143	12	hours	hour	NOUN
admet-514	143	13	to	to	ADP
admet-514	143	14	5.3	5.3	NUM
admet-514	143	15	%	%	NOUN
admet-514	143	16	of	of	ADP
admet-514	143	17	that	that	PRON
admet-514	143	18	after	after	ADP
admet-514	143	19	2	2	NUM
admet-514	143	20	hours	hour	NOUN
admet-514	143	21	.	.	PUNCT
admet-514	144	1	also	also	ADV
admet-514	144	2	,	,	PUNCT
admet-514	144	3	total	total	ADJ
admet-514	144	4	sorafenib	sorafenib	NOUN
admet-514	144	5	accumulation	accumulation	NOUN
admet-514	144	6	decreased	decrease	VERB
admet-514	144	7	considerably	considerably	ADV
admet-514	144	8	from	from	ADP
admet-514	144	9	2	2	NUM
admet-514	144	10	to	to	PART
admet-514	144	11	24	24	NUM
admet-514	144	12	hours	hour	NOUN
admet-514	144	13	.	.	PUNCT
admet-514	145	1	in	in	ADP
admet-514	145	2	contrast	contrast	NOUN
admet-514	145	3	to	to	ADP
admet-514	145	4	the	the	DET
admet-514	145	5	five	five	NUM
admet-514	145	6	other	other	ADJ
admet-514	145	7	tkis	tkis	NOUN
admet-514	145	8	,	,	PUNCT
admet-514	145	9	the	the	DET
admet-514	145	10	total	total	ADJ
admet-514	145	11	absolute	absolute	ADJ
admet-514	145	12	amount	amount	NOUN
admet-514	145	13	of	of	ADP
admet-514	145	14	dasatinib	dasatinib	NOUN
admet-514	145	15	accumulation	accumulation	NOUN
admet-514	145	16	in	in	ADP
admet-514	145	17	the	the	DET
admet-514	145	18	cell	cell	NOUN
admet-514	145	19	hardly	hardly	ADV
admet-514	145	20	changed	change	VERB
admet-514	145	21	after	after	ADP
admet-514	145	22	24	24	NUM
admet-514	145	23	hours	hour	NOUN
admet-514	145	24	compared	compare	VERB
admet-514	145	25	to	to	ADP
admet-514	145	26	2	2	NUM
admet-514	145	27	hours	hour	NOUN
admet-514	145	28	.	.	PUNCT
admet-514	146	1	discussion	discussion	NOUN
admet-514	146	2	the	the	DET
admet-514	146	3	data	datum	NOUN
admet-514	146	4	show	show	VERB
admet-514	146	5	a	a	DET
admet-514	146	6	large	large	ADJ
admet-514	146	7	difference	difference	NOUN
admet-514	146	8	in	in	ADP
admet-514	146	9	both	both	CCONJ
admet-514	146	10	the	the	DET
admet-514	146	11	cellular	cellular	ADJ
admet-514	146	12	uptake	uptake	NOUN
admet-514	146	13	and	and	CCONJ
admet-514	146	14	distribution	distribution	NOUN
admet-514	146	15	.	.	PUNCT
admet-514	147	1	structurally	structurally	ADV
admet-514	147	2	the	the	DET
admet-514	147	3	tkis	tkis	NOUN
admet-514	147	4	investigated	investigate	VERB
admet-514	147	5	differ	differ	VERB
admet-514	147	6	significantly	significantly	ADV
admet-514	147	7	(	(	PUNCT
admet-514	147	8	figure	figure	NOUN
admet-514	147	9	2	2	NUM
admet-514	147	10	)	)	PUNCT
admet-514	147	11	with	with	ADP
admet-514	147	12	a	a	DET
admet-514	147	13	smile	smile	ADJ
admet-514	147	14	correlations	correlation	NOUN
admet-514	147	15	of	of	ADP
admet-514	147	16	less	less	ADJ
admet-514	147	17	than	than	ADP
admet-514	147	18	0.4	0.4	NUM
admet-514	147	19	with	with	ADP
admet-514	147	20	a	a	DET
admet-514	147	21	median	median	NOUN
admet-514	147	22	of	of	ADP
admet-514	147	23	0.206538	0.206538	NUM
admet-514	147	24	(	(	PUNCT
admet-514	147	25	range	range	NOUN
admet-514	147	26	0.154453	0.154453	NUM
admet-514	147	27	–	–	PUNCT
admet-514	147	28	0.389155	0.389155	NUM
admet-514	147	29	)	)	PUNCT
admet-514	147	30	as	as	SCONJ
admet-514	147	31	calculated	calculate	VERB
admet-514	147	32	by	by	ADP
admet-514	147	33	chemmine	chemmine	NOUN
admet-514	147	34	,	,	PUNCT
admet-514	147	35	table	table	NOUN
admet-514	147	36	3	3	NUM
admet-514	147	37	[	[	X
admet-514	147	38	15	15	NUM
admet-514	147	39	]	]	PUNCT
admet-514	147	40	.	.	PUNCT
admet-514	148	1	no	no	DET
admet-514	148	2	relationship	relationship	NOUN
admet-514	148	3	could	could	AUX
admet-514	148	4	be	be	AUX
admet-514	148	5	determined	determine	VERB
admet-514	148	6	between	between	ADP
admet-514	148	7	the	the	DET
admet-514	148	8	cellular	cellular	ADJ
admet-514	148	9	localization	localization	NOUN
admet-514	148	10	of	of	ADP
admet-514	148	11	the	the	DET
admet-514	148	12	molecules	molecule	NOUN
admet-514	148	13	to	to	ADP
admet-514	148	14	their	their	PRON
admet-514	148	15	structural	structural	ADJ
admet-514	148	16	makeup	makeup	NOUN
admet-514	148	17	.	.	PUNCT
admet-514	149	1	the	the	DET
admet-514	149	2	nature	nature	NOUN
admet-514	149	3	of	of	ADP
admet-514	149	4	the	the	DET
admet-514	149	5	accumulation	accumulation	NOUN
admet-514	149	6	of	of	ADP
admet-514	149	7	these	these	DET
admet-514	149	8	compounds	compound	NOUN
admet-514	149	9	is	be	AUX
admet-514	149	10	highly	highly	ADV
admet-514	149	11	dependent	dependent	ADJ
admet-514	149	12	on	on	ADP
admet-514	149	13	the	the	DET
admet-514	149	14	degree	degree	NOUN
admet-514	149	15	to	to	PART
admet-514	149	16	which	which	PRON
admet-514	149	17	they	they	PRON
admet-514	149	18	are	be	AUX
admet-514	149	19	lysosomally	lysosomally	ADV
admet-514	149	20	accumulated	accumulate	VERB
admet-514	149	21	,	,	PUNCT
admet-514	149	22	our	our	PRON
admet-514	149	23	data	datum	NOUN
admet-514	149	24	demonstrates	demonstrate	VERB
admet-514	149	25	that	that	SCONJ
admet-514	149	26	sunitinib	sunitinib	NOUN
admet-514	149	27	and	and	CCONJ
admet-514	149	28	crizotinib	crizotinib	NOUN
admet-514	149	29	are	be	AUX
admet-514	149	30	in	in	ADP
admet-514	149	31	agreement	agreement	NOUN
admet-514	149	32	with	with	ADP
admet-514	149	33	the	the	DET
admet-514	149	34	physical	physical	ADJ
admet-514	149	35	properties	property	NOUN
admet-514	149	36	of	of	ADP
admet-514	149	37	lysosomal	lysosomal	ADJ
admet-514	149	38	accumulation	accumulation	NOUN
admet-514	149	39	.	.	PUNCT
admet-514	150	1	for	for	ADP
admet-514	150	2	sunitinib	sunitinib	NOUN
admet-514	150	3	,	,	PUNCT
admet-514	150	4	the	the	DET
admet-514	150	5	lysosomal	lysosomal	ADJ
admet-514	150	6	accumulation	accumulation	NOUN
admet-514	150	7	has	have	AUX
admet-514	150	8	also	also	ADV
admet-514	150	9	been	be	AUX
admet-514	150	10	demonstrated	demonstrate	VERB
admet-514	150	11	by	by	ADP
admet-514	150	12	using	use	VERB
admet-514	150	13	its	its	PRON
admet-514	150	14	fluorescent	fluorescent	ADJ
admet-514	150	15	properties	property	NOUN
admet-514	150	16	which	which	PRON
admet-514	150	17	co	co	VERB
admet-514	150	18	-	-	VERB
admet-514	150	19	localized	localized	ADJ
admet-514	150	20	with	with	ADP
admet-514	150	21	the	the	DET
admet-514	150	22	lysotracker	lysotracker	NOUN
admet-514	150	23	,	,	PUNCT
admet-514	150	24	a	a	DET
admet-514	150	25	marker	marker	NOUN
admet-514	150	26	for	for	ADP
admet-514	150	27	lysosomes	lysosome	NOUN
admet-514	150	28	[	[	X
admet-514	150	29	7	7	NUM
admet-514	150	30	]	]	PUNCT
admet-514	150	31	.	.	PUNCT
admet-514	151	1	moreover	moreover	ADV
admet-514	151	2	,	,	PUNCT
admet-514	151	3	pre	pre	ADJ
admet-514	151	4	-	-	NOUN
admet-514	151	5	incubation	incubation	NOUN
admet-514	151	6	with	with	ADP
admet-514	151	7	bafilomycin	bafilomycin	PROPN
admet-514	151	8	-	-	PUNCT
admet-514	151	9	a	a	DET
admet-514	151	10	prevented	prevent	VERB
admet-514	151	11	trapping	trapping	NOUN
admet-514	151	12	of	of	ADP
admet-514	151	13	sunitinib	sunitinib	NOUN
admet-514	151	14	in	in	ADP
admet-514	151	15	the	the	DET
admet-514	151	16	lysosomes	lysosome	NOUN
admet-514	151	17	[	[	X
admet-514	151	18	7,16	7,16	NOUN
admet-514	151	19	]	]	X
admet-514	151	20	.	.	PUNCT
admet-514	152	1	sunitinib	sunitinib	NOUN
admet-514	152	2	achieves	achieve	VERB
admet-514	152	3	very	very	ADV
admet-514	152	4	high	high	ADJ
admet-514	152	5	cellular	cellular	ADJ
admet-514	152	6	concentrations	concentration	NOUN
admet-514	152	7	since	since	SCONJ
admet-514	152	8	it	it	PRON
admet-514	152	9	has	have	AUX
admet-514	152	10	been	be	AUX
admet-514	152	11	shown	show	VERB
admet-514	152	12	that	that	SCONJ
admet-514	152	13	90	90	NUM
admet-514	152	14	%	%	NOUN
admet-514	152	15	of	of	ADP
admet-514	152	16	accumulated	accumulate	VERB
admet-514	152	17	drug	drug	NOUN
admet-514	152	18	is	be	AUX
admet-514	152	19	held	hold	VERB
admet-514	152	20	within	within	ADP
admet-514	152	21	lysosomes	lysosome	NOUN
admet-514	152	22	within	within	ADP
admet-514	152	23	the	the	DET
admet-514	152	24	cell	cell	NOUN
admet-514	152	25	structure	structure	NOUN
admet-514	152	26	.	.	PUNCT
admet-514	153	1	the	the	DET
admet-514	153	2	cell	cell	NOUN
admet-514	153	3	survives	survive	VERB
admet-514	153	4	this	this	DET
admet-514	153	5	accumulation	accumulation	NOUN
admet-514	153	6	since	since	SCONJ
admet-514	153	7	the	the	DET
admet-514	153	8	bulk	bulk	NOUN
admet-514	153	9	of	of	ADP
admet-514	153	10	the	the	DET
admet-514	153	11	drug	drug	NOUN
admet-514	153	12	is	be	AUX
admet-514	153	13	isolated	isolate	VERB
admet-514	153	14	away	away	ADV
admet-514	153	15	from	from	ADP
admet-514	153	16	its	its	PRON
admet-514	153	17	targets	target	NOUN
admet-514	153	18	.	.	PUNCT
admet-514	154	1	the	the	DET
admet-514	154	2	relationship	relationship	NOUN
admet-514	154	3	between	between	ADP
admet-514	154	4	physiochemical	physiochemical	ADJ
admet-514	154	5	properties	property	NOUN
admet-514	154	6	and	and	CCONJ
admet-514	154	7	the	the	DET
admet-514	154	8	observed	observed	ADJ
admet-514	154	9	absorption	absorption	NOUN
admet-514	154	10	characteristics	characteristic	NOUN
admet-514	154	11	is	be	AUX
admet-514	154	12	currently	currently	ADV
admet-514	154	13	under	under	ADP
admet-514	154	14	investigation	investigation	NOUN
admet-514	154	15	and	and	CCONJ
admet-514	154	16	out	out	ADP
admet-514	154	17	of	of	ADP
admet-514	154	18	the	the	DET
admet-514	154	19	scope	scope	NOUN
admet-514	154	20	of	of	ADP
admet-514	154	21	this	this	DET
admet-514	154	22	paper	paper	NOUN
admet-514	154	23	.	.	PUNCT
admet-514	155	1	table	table	NOUN
admet-514	155	2	3	3	NUM
admet-514	155	3	.	.	PUNCT
admet-514	155	4	comparison	comparison	NOUN
admet-514	155	5	of	of	ADP
admet-514	155	6	molecular	molecular	ADJ
admet-514	155	7	structures	structure	NOUN
admet-514	155	8	for	for	ADP
admet-514	155	9	crizotinib	crizotinib	NOUN
admet-514	155	10	,	,	PUNCT
admet-514	155	11	dasatinib	dasatinib	NOUN
admet-514	155	12	,	,	PUNCT
admet-514	155	13	erlotinib	erlotinib	NOUN
admet-514	155	14	,	,	PUNCT
admet-514	155	15	gefitinib	gefitinib	NOUN
admet-514	155	16	,	,	PUNCT
admet-514	155	17	sorafenib	sorafenib	NOUN
admet-514	155	18	and	and	CCONJ
admet-514	155	19	sunitinib	sunitinib	NOUN
admet-514	155	20	using	use	VERB
admet-514	155	21	chemmine	chemmine	NOUN
admet-514	155	22	correlation	correlation	NOUN
admet-514	155	23	of	of	ADP
admet-514	155	24	smiles	smile	NOUN
admet-514	155	25	.	.	PUNCT
admet-514	156	1	crizotinib	crizotinib	VERB
admet-514	156	2	dasatinib	dasatinib	NOUN
admet-514	156	3	erlotinib	erlotinib	PROPN
admet-514	156	4	gefitinib	gefitinib	NOUN
admet-514	156	5	sorafenib	sorafenib	VERB
admet-514	156	6	sunitinib	sunitinib	NOUN
admet-514	156	7	crizotinib	crizotinib	VERB
admet-514	156	8	0.231458	0.231458	NUM
admet-514	156	9	0.196302	0.196302	NUM
admet-514	156	10	0.285714	0.285714	NUM
admet-514	156	11	0.156522	0.156522	NUM
admet-514	156	12	0.203147	0.203147	NUM
admet-514	156	13	dasatinib	dasatinib	NOUN
admet-514	156	14	0.231458	0.231458	NUM
admet-514	156	15	0.208279	0.208279	NUM
admet-514	156	16	0.296345	0.296345	NUM
admet-514	156	17	0.154453	0.154453	NUM
admet-514	156	18	0.275956	0.275956	NUM
admet-514	156	19	erlotinib	erlotinib	NOUN
admet-514	156	20	0.196302	0.196302	NUM
admet-514	156	21	0.208279	0.208279	NUM
admet-514	156	22	0.389155	0.389155	NUM
admet-514	156	23	0.17601	0.17601	NUM
admet-514	156	24	0.206538	0.206538	NUM
admet-514	156	25	gefitinib	gefitinib	NOUN
admet-514	156	26	0.285714	0.285714	NUM
admet-514	156	27	0.296345	0.296345	NUM
admet-514	156	28	0.389155	0.389155	NUM
admet-514	156	29	0.18059	0.18059	NUM
admet-514	156	30	0.262319	0.262319	NUM
admet-514	156	31	sorafenib	sorafenib	NOUN
admet-514	156	32	0.156522	0.156522	NUM
admet-514	156	33	0.154453	0.154453	NUM
admet-514	156	34	0.17601	0.17601	NUM
admet-514	156	35	0.18059	0.18059	NUM
admet-514	156	36	0.191546	0.191546	NUM
admet-514	156	37	sunitinib	sunitinib	NOUN
admet-514	156	38	0.203147	0.203147	NUM
admet-514	156	39	0.275956	0.275956	NUM
admet-514	156	40	0.206538	0.206538	NUM
admet-514	157	1	0.262319	0.262319	NUM
admet-514	157	2	0.191546	0.191546	NUM
admet-514	157	3	richard	richard	PROPN
admet-514	157	4	honeywell	honeywell	PROPN
admet-514	157	5	et	et	PROPN
admet-514	157	6	al	al	PROPN
admet-514	157	7	.	.	PROPN
admet-514	157	8	admet	admet	PROPN
admet-514	157	9	&	&	CCONJ
admet-514	157	10	dmpk	dmpk	PROPN
admet-514	157	11	6(3	6(3	PROPN
admet-514	157	12	)	)	PUNCT
admet-514	157	13	(	(	PUNCT
admet-514	157	14	2018	2018	NUM
admet-514	157	15	)	)	PUNCT
admet-514	157	16	258	258	NUM
admet-514	157	17	-	-	SYM
admet-514	157	18	266	266	NUM
admet-514	157	19	264	264	NUM
admet-514	157	20	cl	cl	NOUN
admet-514	157	21	hn	hn	PROPN
admet-514	157	22	os	os	PROPN
admet-514	157	23	n	n	CCONJ
admet-514	157	24	n	n	PROPN
admet-514	157	25	h	h	NOUN
admet-514	157	26	nn	nn	PROPN
admet-514	157	27	n	n	CCONJ
admet-514	157	28	n	n	CCONJ
admet-514	157	29	ho	ho	PROPN
admet-514	157	30	dasatinib	dasatinib	NOUN
admet-514	157	31	exact	exact	ADJ
admet-514	157	32	mass	mass	NOUN
admet-514	157	33	:	:	PUNCT
admet-514	157	34	487.16	487.16	NUM
admet-514	157	35	molecular	molecular	ADJ
admet-514	157	36	weight	weight	NOUN
admet-514	157	37	:	:	PUNCT
admet-514	157	38	488.01	488.01	NUM
admet-514	157	39	protein	protein	NOUN
admet-514	157	40	binding	bind	VERB
admet-514	157	41	:	:	PUNCT
admet-514	157	42	96	96	NUM
admet-514	157	43	%	%	NOUN
admet-514	157	44	gibbs	gibbs	PROPN
admet-514	157	45	energy	energy	NOUN
admet-514	157	46	:	:	PUNCT
admet-514	157	47	836.07	836.07	NUM
admet-514	157	48	[	[	X
admet-514	157	49	kj	kj	PROPN
admet-514	157	50	/	/	SYM
admet-514	157	51	mol	mol	PROPN
admet-514	157	52	]	]	PUNCT
admet-514	157	53	log	log	NOUN
admet-514	157	54	p	p	X
admet-514	157	55	:	:	PUNCT
admet-514	157	56	5.06	5.06	NUM
admet-514	157	57	n	n	NUM
admet-514	157	58	nh2	nh2	NOUN
admet-514	157	59	o	o	NOUN
admet-514	157	60	cl	cl	NOUN
admet-514	157	61	cl	cl	NOUN
admet-514	158	1	fn	fn	NOUN
admet-514	159	1	n	n	INTJ
admet-514	159	2	hn	hn	INTJ
admet-514	159	3	log	log	VERB
admet-514	159	4	p	p	X
admet-514	159	5	:	:	PUNCT
admet-514	159	6	3.39	3.39	NUM
admet-514	159	7	crizotinib	crizotinib	VERB
admet-514	159	8	exact	exact	ADJ
admet-514	159	9	mass	mass	NOUN
admet-514	159	10	:	:	PUNCT
admet-514	159	11	449.12	449.12	NUM
admet-514	159	12	molecular	molecular	ADJ
admet-514	159	13	weight	weight	NOUN
admet-514	159	14	:	:	PUNCT
admet-514	159	15	450.34	450.34	NUM
admet-514	159	16	protein	protein	NOUN
admet-514	159	17	binding	bind	VERB
admet-514	159	18	:	:	PUNCT
admet-514	160	1	<	<	X
admet-514	160	2	90	90	NUM
admet-514	160	3	%	%	NOUN
admet-514	160	4	hn	hn	PROPN
admet-514	160	5	n	n	PROPN
admet-514	160	6	n	n	ADV
admet-514	160	7	o	o	NOUN
admet-514	160	8	oo	oo	INTJ
admet-514	160	9	o	o	X
admet-514	160	10	erlotinib	erlotinib	NOUN
admet-514	160	11	exact	exact	ADJ
admet-514	160	12	mass	mass	NOUN
admet-514	160	13	:	:	PUNCT
admet-514	160	14	393.17	393.17	NUM
admet-514	160	15	molecular	molecular	ADJ
admet-514	160	16	weight	weight	NOUN
admet-514	160	17	:	:	PUNCT
admet-514	160	18	393.44	393.44	NUM
admet-514	160	19	protein	protein	NOUN
admet-514	160	20	binding	bind	VERB
admet-514	160	21	:	:	PUNCT
admet-514	160	22	~95	~95	NUM
admet-514	160	23	%	%	X
admet-514	160	24	gibbs	gibbs	PROPN
admet-514	160	25	energy	energy	NOUN
admet-514	160	26	:	:	PUNCT
admet-514	160	27	473.87	473.87	NUM
admet-514	160	28	[	[	X
admet-514	160	29	kj	kj	PROPN
admet-514	160	30	/	/	SYM
admet-514	160	31	mol	mol	PROPN
admet-514	160	32	]	]	PUNCT
admet-514	160	33	log	log	NOUN
admet-514	160	34	p	p	NOUN
admet-514	160	35	:	:	PUNCT
admet-514	160	36	3.3	3.3	NUM
admet-514	160	37	f	f	NOUN
admet-514	160	38	cl	cl	NOUN
admet-514	160	39	hn	hn	PROPN
admet-514	160	40	n	n	ADV
admet-514	160	41	n	n	ADV
admet-514	160	42	o	o	NOUN
admet-514	160	43	o	o	X
admet-514	160	44	n	n	CCONJ
admet-514	160	45	o	o	NOUN
admet-514	160	46	gefitinib	gefitinib	NOUN
admet-514	160	47	exact	exact	ADJ
admet-514	160	48	mass	mass	NOUN
admet-514	160	49	:	:	PUNCT
admet-514	160	50	446.15	446.15	NUM
admet-514	160	51	molecular	molecular	ADJ
admet-514	160	52	weight	weight	NOUN
admet-514	160	53	:	:	PUNCT
admet-514	160	54	446.9	446.9	NUM
admet-514	160	55	protein	protein	NOUN
admet-514	160	56	binding	bind	VERB
admet-514	160	57	:	:	PUNCT
admet-514	160	58	~90	~90	NUM
admet-514	160	59	%	%	X
admet-514	160	60	gibbs	gibbs	PROPN
admet-514	160	61	energy	energy	NOUN
admet-514	160	62	:	:	PUNCT
admet-514	160	63	313.35	313.35	NUM
admet-514	160	64	[	[	X
admet-514	160	65	kj	kj	PROPN
admet-514	160	66	/	/	SYM
admet-514	160	67	mol	mol	PROPN
admet-514	160	68	]	]	PUNCT
admet-514	160	69	log	log	NOUN
admet-514	160	70	p	p	NOUN
admet-514	160	71	:	:	PUNCT
admet-514	160	72	3.87	3.87	NUM
admet-514	160	73	o	o	NOUN
admet-514	160	74	nh	nh	PROPN
admet-514	160	75	n	n	ADV
admet-514	160	76	h	h	NOUN
admet-514	160	77	f	f	NOUN
admet-514	160	78	o	o	PROPN
admet-514	160	79	nh	nh	PROPN
admet-514	160	80	n	n	PROPN
admet-514	160	81	sunitinib	sunitinib	NOUN
admet-514	160	82	exact	exact	ADJ
admet-514	160	83	mass	mass	NOUN
admet-514	160	84	:	:	PUNCT
admet-514	160	85	398.21	398.21	NUM
admet-514	160	86	molecular	molecular	ADJ
admet-514	160	87	weight	weight	NOUN
admet-514	160	88	:	:	PUNCT
admet-514	161	1	398.47	398.47	NUM
admet-514	161	2	hn	hn	PROPN
admet-514	161	3	o	o	NOUN
admet-514	161	4	n	n	CCONJ
admet-514	161	5	o	o	NOUN
admet-514	161	6	n	n	CCONJ
admet-514	161	7	h	h	NOUN
admet-514	162	1	o	o	NOUN
admet-514	162	2	n	n	CCONJ
admet-514	162	3	h	h	NOUN
admet-514	162	4	cl	cl	NOUN
admet-514	162	5	f	f	PROPN
admet-514	162	6	f	f	PROPN
admet-514	162	7	f	f	PROPN
admet-514	162	8	sorafenib	sorafenib	PROPN
admet-514	162	9	exact	exact	VERB
admet-514	162	10	mass	mass	NOUN
admet-514	162	11	:	:	PUNCT
admet-514	162	12	464.09	464.09	NUM
admet-514	162	13	molecular	molecular	ADJ
admet-514	162	14	weight	weight	NOUN
admet-514	162	15	:	:	PUNCT
admet-514	163	1	464.82	464.82	NUM
admet-514	163	2	log	log	NOUN
admet-514	163	3	p	p	X
admet-514	163	4	:	:	PUNCT
admet-514	163	5	2.03	2.03	NUM
admet-514	163	6	gibbs	gibbs	PROPN
admet-514	163	7	energy	energy	NOUN
admet-514	163	8	:	:	PUNCT
admet-514	163	9	-225.59	-225.59	PROPN
admet-514	164	1	[	[	X
admet-514	164	2	kj	kj	PROPN
admet-514	164	3	/	/	SYM
admet-514	164	4	mol	mol	PROPN
admet-514	164	5	]	]	PUNCT
admet-514	164	6	log	log	NOUN
admet-514	164	7	p	p	X
admet-514	164	8	:	:	PUNCT
admet-514	164	9	3.76	3.76	NUM
admet-514	164	10	figure	figure	NOUN
admet-514	164	11	2	2	NUM
admet-514	164	12	.	.	PUNCT
admet-514	165	1	the	the	DET
admet-514	165	2	molecular	molecular	ADJ
admet-514	165	3	structures	structure	NOUN
admet-514	165	4	and	and	CCONJ
admet-514	165	5	know	know	VERB
admet-514	165	6	physical	physical	ADJ
admet-514	165	7	chemical	chemical	NOUN
admet-514	165	8	properties	property	NOUN
admet-514	165	9	for	for	ADP
admet-514	165	10	the	the	DET
admet-514	165	11	six	six	NUM
admet-514	165	12	tyrosine	tyrosine	NOUN
admet-514	165	13	kinase	kinase	NOUN
admet-514	165	14	inhibitors	inhibitor	NOUN
admet-514	165	15	under	under	ADP
admet-514	165	16	investigation	investigation	NOUN
admet-514	165	17	also	also	ADV
admet-514	165	18	,	,	PUNCT
admet-514	165	19	for	for	ADP
admet-514	165	20	crizotinib	crizotinib	NOUN
admet-514	165	21	we	we	PRON
admet-514	165	22	demonstrated	demonstrate	VERB
admet-514	165	23	that	that	SCONJ
admet-514	165	24	bafilomycin	bafilomycin	PROPN
admet-514	165	25	prevented	prevent	VERB
admet-514	165	26	uptake	uptake	NOUN
admet-514	165	27	into	into	ADP
admet-514	165	28	lysosomes	lysosome	NOUN
admet-514	165	29	(	(	PUNCT
admet-514	165	30	unpublished	unpublished	ADJ
admet-514	165	31	data	datum	NOUN
admet-514	165	32	)	)	PUNCT
admet-514	165	33	.	.	PUNCT
admet-514	166	1	trapping	trap	VERB
admet-514	166	2	of	of	ADP
admet-514	166	3	these	these	DET
admet-514	166	4	drugs	drug	NOUN
admet-514	166	5	is	be	AUX
admet-514	166	6	possibly	possibly	ADV
admet-514	166	7	mediated	mediate	VERB
admet-514	166	8	by	by	ADP
admet-514	166	9	a	a	DET
admet-514	166	10	selective	selective	ADJ
admet-514	166	11	uptake	uptake	NOUN
admet-514	166	12	of	of	ADP
admet-514	166	13	the	the	DET
admet-514	166	14	drugs	drug	NOUN
admet-514	166	15	via	via	ADP
admet-514	166	16	multidrug	multidrug	NOUN
admet-514	166	17	resistance	resistance	NOUN
admet-514	166	18	proteins	protein	NOUN
admet-514	166	19	,	,	PUNCT
admet-514	166	20	subsequently	subsequently	ADV
admet-514	166	21	the	the	DET
admet-514	166	22	drugs	drug	NOUN
admet-514	166	23	are	be	AUX
admet-514	166	24	protonated	protonate	VERB
admet-514	166	25	and	and	CCONJ
admet-514	166	26	can	can	AUX
admet-514	166	27	not	not	PART
admet-514	166	28	subsequently	subsequently	ADV
admet-514	166	29	be	be	AUX
admet-514	166	30	effluxed	effluxe	VERB
admet-514	167	1	anymore	anymore	ADV
admet-514	167	2	[	[	X
admet-514	167	3	17,18	17,18	NUM
admet-514	167	4	]	]	X
admet-514	167	5	.	.	PUNCT
admet-514	168	1	for	for	ADP
admet-514	168	2	erlotinib	erlotinib	NOUN
admet-514	168	3	it	it	PRON
admet-514	168	4	is	be	AUX
admet-514	168	5	likely	likely	ADJ
admet-514	168	6	that	that	SCONJ
admet-514	168	7	it	it	PRON
admet-514	168	8	is	be	AUX
admet-514	168	9	transported	transport	VERB
admet-514	168	10	into	into	ADP
admet-514	168	11	the	the	DET
admet-514	168	12	membrane	membrane	NOUN
admet-514	168	13	,	,	PUNCT
admet-514	168	14	binds	bind	VERB
admet-514	168	15	to	to	ADP
admet-514	168	16	its	its	PRON
admet-514	168	17	target	target	NOUN
admet-514	168	18	,	,	PUNCT
admet-514	168	19	but	but	CCONJ
admet-514	168	20	is	be	AUX
admet-514	168	21	effluxed	effluxe	VERB
admet-514	168	22	before	before	SCONJ
admet-514	168	23	it	it	PRON
admet-514	168	24	can	can	AUX
admet-514	168	25	enter	enter	VERB
admet-514	168	26	the	the	DET
admet-514	168	27	cell	cell	NOUN
admet-514	168	28	[	[	X
admet-514	168	29	19	19	NUM
admet-514	168	30	]	]	PUNCT
admet-514	168	31	.	.	PUNCT
admet-514	169	1	in	in	ADP
admet-514	169	2	contrast	contrast	NOUN
admet-514	169	3	,	,	PUNCT
admet-514	169	4	the	the	DET
admet-514	169	5	other	other	ADJ
admet-514	169	6	egfr	egfr	NOUN
admet-514	169	7	targeted	target	VERB
admet-514	169	8	drug	drug	NOUN
admet-514	169	9	(	(	PUNCT
admet-514	169	10	gefitinib	gefitinib	NOUN
admet-514	169	11	)	)	PUNCT
admet-514	169	12	is	be	AUX
admet-514	169	13	taken	take	VERB
admet-514	169	14	up	up	ADP
admet-514	169	15	by	by	ADP
admet-514	169	16	an	an	DET
admet-514	169	17	active	active	ADJ
admet-514	169	18	transporter	transporter	NOUN
admet-514	169	19	[	[	X
admet-514	169	20	13,20,21	13,20,21	NUM
admet-514	169	21	]	]	PUNCT
admet-514	169	22	and	and	CCONJ
admet-514	169	23	subsequently	subsequently	ADV
admet-514	169	24	trapped	trap	VERB
admet-514	169	25	in	in	ADP
admet-514	169	26	the	the	DET
admet-514	169	27	cell	cell	NOUN
admet-514	169	28	.	.	PUNCT
admet-514	170	1	sorafenib	sorafenib	PROPN
admet-514	170	2	is	be	AUX
admet-514	170	3	not	not	PART
admet-514	170	4	only	only	ADV
admet-514	170	5	actively	actively	ADV
admet-514	170	6	being	be	AUX
admet-514	170	7	transported	transport	VERB
admet-514	170	8	into	into	ADP
admet-514	170	9	the	the	DET
admet-514	170	10	cell	cell	NOUN
admet-514	170	11	but	but	CCONJ
admet-514	170	12	is	be	AUX
admet-514	170	13	possibly	possibly	ADV
admet-514	170	14	also	also	ADV
admet-514	170	15	trapped	trap	VERB
admet-514	170	16	in	in	ADP
admet-514	170	17	the	the	DET
admet-514	170	18	cell	cell	NOUN
admet-514	170	19	,	,	PUNCT
admet-514	170	20	either	either	CCONJ
admet-514	170	21	as	as	ADP
admet-514	170	22	the	the	DET
admet-514	170	23	parent	parent	NOUN
admet-514	170	24	drug	drug	NOUN
admet-514	170	25	or	or	CCONJ
admet-514	170	26	as	as	ADP
admet-514	170	27	a	a	DET
admet-514	170	28	metabolite	metabolite	NOUN
admet-514	170	29	,	,	PUNCT
admet-514	170	30	since	since	SCONJ
admet-514	170	31	it	it	PRON
admet-514	170	32	is	be	AUX
admet-514	170	33	substrate	substrate	NOUN
admet-514	170	34	for	for	ADP
admet-514	170	35	various	various	ADJ
admet-514	170	36	phase	phase	NOUN
admet-514	171	1	i	i	PRON
admet-514	171	2	and	and	CCONJ
admet-514	171	3	phase	phase	NOUN
admet-514	171	4	ii	ii	NOUN
admet-514	171	5	enzymes	enzyme	NOUN
admet-514	171	6	[	[	X
admet-514	171	7	22,23	22,23	NOUN
admet-514	171	8	]	]	PUNCT
admet-514	171	9	.	.	PUNCT
admet-514	172	1	it	it	PRON
admet-514	172	2	seems	seem	VERB
admet-514	172	3	to	to	PART
admet-514	172	4	be	be	AUX
admet-514	172	5	effluxed	effluxe	VERB
admet-514	172	6	efficiently	efficiently	ADV
admet-514	172	7	from	from	ADP
admet-514	172	8	the	the	DET
admet-514	172	9	cell	cell	NOUN
admet-514	172	10	.	.	PUNCT
admet-514	173	1	lastly	lastly	ADV
admet-514	173	2	,	,	PUNCT
admet-514	173	3	dasatinib	dasatinib	NOUN
admet-514	173	4	is	be	AUX
admet-514	173	5	taken	take	VERB
admet-514	173	6	up	up	ADP
admet-514	173	7	by	by	ADP
admet-514	173	8	the	the	DET
admet-514	173	9	cell	cell	NOUN
admet-514	173	10	,	,	PUNCT
admet-514	173	11	but	but	CCONJ
admet-514	173	12	is	be	AUX
admet-514	173	13	not	not	PART
admet-514	173	14	further	far	ADV
admet-514	173	15	distributed	distribute	VERB
admet-514	173	16	and	and	CCONJ
admet-514	173	17	is	be	AUX
admet-514	173	18	not	not	PART
admet-514	173	19	effluxed	effluxe	VERB
admet-514	173	20	efficiently	efficiently	ADV
admet-514	173	21	either	either	ADV
admet-514	173	22	.	.	PUNCT
admet-514	174	1	however	however	ADV
admet-514	174	2	,	,	PUNCT
admet-514	174	3	its	its	PRON
admet-514	174	4	cytosolic	cytosolic	ADJ
admet-514	174	5	localization	localization	NOUN
admet-514	174	6	is	be	AUX
admet-514	174	7	in	in	ADP
admet-514	174	8	line	line	NOUN
admet-514	174	9	with	with	ADP
admet-514	174	10	its	its	PRON
admet-514	174	11	high	high	ADJ
admet-514	174	12	efficacy	efficacy	NOUN
admet-514	174	13	since	since	SCONJ
admet-514	174	14	its	its	PRON
admet-514	174	15	target	target	NOUN
admet-514	174	16	bcr	bcr	NOUN
admet-514	174	17	-	-	PROPN
admet-514	174	18	abl	abl	PROPN
admet-514	174	19	(	(	PUNCT
admet-514	174	20	only	only	ADV
admet-514	174	21	in	in	ADP
admet-514	174	22	chronic	chronic	ADJ
admet-514	174	23	myeloid	myeloid	NOUN
admet-514	174	24	leukemia	leukemia	NOUN
admet-514	174	25	)	)	PUNCT
admet-514	174	26	is	be	AUX
admet-514	174	27	located	locate	VERB
admet-514	174	28	in	in	ADP
admet-514	174	29	the	the	DET
admet-514	174	30	cytosol	cytosol	NOUN
admet-514	174	31	[	[	X
admet-514	174	32	1	1	NUM
admet-514	174	33	]	]	PUNCT
admet-514	174	34	.	.	PUNCT
admet-514	175	1	admet	admet	PROPN
admet-514	175	2	&	&	CCONJ
admet-514	175	3	dmpk	dmpk	PROPN
admet-514	175	4	6(3	6(3	PROPN
admet-514	175	5	)	)	PUNCT
admet-514	175	6	(	(	PUNCT
admet-514	175	7	2018	2018	NUM
admet-514	175	8	)	)	PUNCT
admet-514	175	9	258	258	NUM
admet-514	175	10	-	-	PUNCT
admet-514	175	11	266	266	NUM
admet-514	175	12	subcellular	subcellular	ADJ
admet-514	175	13	localization	localization	NOUN
admet-514	175	14	of	of	ADP
admet-514	175	15	several	several	ADJ
admet-514	175	16	structurally	structurally	ADV
admet-514	175	17	different	different	ADJ
admet-514	175	18	tkis	tkis	PROPN
admet-514	175	19	doi	doi	NOUN
admet-514	175	20	:	:	PUNCT
admet-514	175	21	10.5599	10.5599	NUM
admet-514	175	22	/	/	SYM
admet-514	175	23	admet.514	admet.514	PROPN
admet-514	175	24	265	265	NUM
admet-514	175	25	conclusion	conclusion	NOUN
admet-514	175	26	protein	protein	NOUN
admet-514	175	27	fractions	fraction	NOUN
admet-514	175	28	contained	contain	VERB
admet-514	175	29	considerable	considerable	ADJ
admet-514	175	30	tki	tki	NOUN
admet-514	175	31	levels	level	NOUN
admet-514	175	32	that	that	PRON
admet-514	175	33	changed	change	VERB
admet-514	175	34	markedly	markedly	ADV
admet-514	175	35	over	over	ADP
admet-514	175	36	time	time	NOUN
admet-514	175	37	.	.	PUNCT
admet-514	176	1	this	this	PRON
admet-514	176	2	could	could	AUX
admet-514	176	3	be	be	AUX
admet-514	176	4	demonstrated	demonstrate	VERB
admet-514	176	5	by	by	ADP
admet-514	176	6	using	use	VERB
admet-514	176	7	the	the	DET
admet-514	176	8	proteoextractr	proteoextractr	ADJ
admet-514	176	9	subcellular	subcellular	ADJ
admet-514	176	10	proteome	proteome	PROPN
admet-514	176	11	extraction	extraction	NOUN
admet-514	176	12	kit	kit	NOUN
admet-514	176	13	.	.	PUNCT
admet-514	177	1	in	in	ADP
admet-514	177	2	addition	addition	NOUN
admet-514	177	3	,	,	PUNCT
admet-514	177	4	it	it	PRON
admet-514	177	5	can	can	AUX
admet-514	177	6	be	be	AUX
admet-514	177	7	concluded	conclude	VERB
admet-514	177	8	that	that	SCONJ
admet-514	177	9	the	the	DET
admet-514	177	10	distribution	distribution	NOUN
admet-514	177	11	of	of	ADP
admet-514	177	12	the	the	DET
admet-514	177	13	six	six	NUM
admet-514	177	14	tkis	tkis	NOUN
admet-514	177	15	differs	differ	VERB
admet-514	177	16	a	a	DET
admet-514	177	17	lot	lot	NOUN
admet-514	177	18	and	and	CCONJ
admet-514	177	19	also	also	ADV
admet-514	177	20	changed	change	VERB
admet-514	177	21	over	over	ADP
admet-514	177	22	time	time	NOUN
admet-514	177	23	.	.	PUNCT
admet-514	178	1	this	this	PRON
admet-514	178	2	may	may	AUX
admet-514	178	3	be	be	AUX
admet-514	178	4	related	relate	VERB
admet-514	178	5	to	to	ADP
admet-514	178	6	the	the	DET
admet-514	178	7	different	different	ADJ
admet-514	178	8	physio	physio	NOUN
admet-514	178	9	-	-	PUNCT
admet-514	178	10	chemical	chemical	NOUN
admet-514	178	11	properties	property	NOUN
admet-514	178	12	of	of	ADP
admet-514	178	13	the	the	DET
admet-514	178	14	various	various	ADJ
admet-514	178	15	tkis	tkis	NOUN
admet-514	178	16	,	,	PUNCT
admet-514	178	17	favouring	favour	VERB
admet-514	178	18	either	either	CCONJ
admet-514	178	19	a	a	DET
admet-514	178	20	lysosomal	lysosomal	ADJ
admet-514	178	21	accumulation	accumulation	NOUN
admet-514	178	22	or	or	CCONJ
admet-514	178	23	a	a	DET
admet-514	178	24	rapid	rapid	ADJ
admet-514	178	25	efflux	efflux	NOUN
admet-514	178	26	from	from	ADP
admet-514	178	27	the	the	DET
admet-514	178	28	cell	cell	NOUN
admet-514	178	29	[	[	X
admet-514	178	30	10	10	NUM
admet-514	178	31	]	]	PUNCT
admet-514	178	32	.	.	PUNCT
admet-514	179	1	nevertheless	nevertheless	ADV
admet-514	179	2	,	,	PUNCT
admet-514	179	3	sunitinib	sunitinib	NOUN
admet-514	179	4	and	and	CCONJ
admet-514	179	5	crizotinib	crizotinib	VERB
admet-514	179	6	distribution	distribution	NOUN
admet-514	179	7	show	show	VERB
admet-514	179	8	comparable	comparable	ADJ
admet-514	179	9	patterns	pattern	NOUN
admet-514	179	10	,	,	PUNCT
admet-514	179	11	probably	probably	ADV
admet-514	179	12	due	due	ADP
admet-514	179	13	to	to	ADP
admet-514	179	14	the	the	DET
admet-514	179	15	lysosomal	lysosomal	ADJ
admet-514	179	16	accumulation	accumulation	NOUN
admet-514	179	17	.	.	PUNCT
admet-514	180	1	references	reference	NOUN
admet-514	180	2	[	[	X
admet-514	180	3	1	1	NUM
admet-514	180	4	]	]	X
admet-514	180	5	f.	f.	PROPN
admet-514	180	6	broekman	broekman	PROPN
admet-514	180	7	,	,	PUNCT
admet-514	180	8	e.	e.	PROPN
admet-514	180	9	giovannetti	giovannetti	PROPN
admet-514	180	10	,	,	PUNCT
admet-514	180	11	g.j	g.j	PROPN
admet-514	180	12	.	.	PROPN
admet-514	180	13	peters	peters	PROPN
admet-514	180	14	.	.	PUNCT
admet-514	181	1	tyrosine	tyrosine	PROPN
admet-514	181	2	kinase	kinase	PROPN
admet-514	181	3	inhibitors	inhibitor	NOUN
admet-514	181	4	:	:	PUNCT
admet-514	181	5	multi	multi	ADJ
admet-514	181	6	-	-	ADJ
admet-514	181	7	targeted	targeted	ADJ
admet-514	181	8	or	or	CCONJ
admet-514	181	9	singletargeted	singletargeted	ADJ
admet-514	181	10	?	?	PUNCT
admet-514	182	1	world	world	PROPN
admet-514	182	2	j.	j.	PROPN
admet-514	182	3	clin	clin	PROPN
admet-514	182	4	.	.	PUNCT
admet-514	183	1	oncol	oncol	ADJ
admet-514	183	2	.	.	PUNCT
admet-514	184	1	2	2	NUM
admet-514	184	2	(	(	PUNCT
admet-514	184	3	2011	2011	NUM
admet-514	184	4	)	)	PUNCT
admet-514	184	5	80–93	80–93	NUM
admet-514	184	6	.	.	PUNCT
admet-514	185	1	[	[	X
admet-514	185	2	2	2	NUM
admet-514	185	3	]	]	PUNCT
admet-514	185	4	r.	r.	NOUN
admet-514	185	5	chebib	chebib	PROPN
admet-514	185	6	,	,	PUNCT
admet-514	185	7	l.	l.	PROPN
admet-514	185	8	verlingue	verlingue	PROPN
admet-514	185	9	,	,	PUNCT
admet-514	185	10	n.	n.	PROPN
admet-514	185	11	cozic	cozic	PROPN
admet-514	185	12	,	,	PUNCT
admet-514	185	13	m.	m.	NOUN
admet-514	185	14	faron	faron	PROPN
admet-514	185	15	,	,	PUNCT
admet-514	185	16	p.	p.	PROPN
admet-514	185	17	burtin	burtin	PROPN
admet-514	185	18	,	,	PUNCT
admet-514	185	19	v.	v.	CCONJ
admet-514	185	20	boige	boige	ADJ
admet-514	185	21	,	,	PUNCT
admet-514	185	22	a.	a.	NOUN
admet-514	185	23	hollebecque	hollebecque	NOUN
admet-514	185	24	,	,	PUNCT
admet-514	185	25	d.	d.	PROPN
admet-514	185	26	malka	malka	PROPN
admet-514	185	27	.	.	PUNCT
admet-514	186	1	angiogenesis	angiogenesis	NOUN
admet-514	186	2	inhibition	inhibition	NOUN
admet-514	186	3	in	in	ADP
admet-514	186	4	the	the	DET
admet-514	186	5	second	second	ADJ
admet-514	186	6	-	-	PUNCT
admet-514	186	7	line	line	NOUN
admet-514	186	8	treatment	treatment	NOUN
admet-514	186	9	of	of	ADP
admet-514	186	10	metastatic	metastatic	ADJ
admet-514	186	11	colorectal	colorectal	ADJ
admet-514	186	12	cancer	cancer	NOUN
admet-514	186	13	:	:	PUNCT
admet-514	186	14	a	a	DET
admet-514	186	15	systematic	systematic	ADJ
admet-514	186	16	review	review	NOUN
admet-514	186	17	and	and	CCONJ
admet-514	186	18	pooled	pool	VERB
admet-514	186	19	analysis	analysis	NOUN
admet-514	186	20	.	.	PUNCT
admet-514	187	1	seminars	seminar	NOUN
admet-514	187	2	in	in	ADP
admet-514	187	3	oncology	oncology	NOUN
admet-514	187	4	44	44	NUM
admet-514	187	5	(	(	PUNCT
admet-514	187	6	2017	2017	NUM
admet-514	187	7	)	)	PUNCT
admet-514	187	8	114–128	114–128	NUM
admet-514	187	9	.	.	PUNCT
admet-514	188	1	[	[	X
admet-514	188	2	3	3	X
admet-514	188	3	]	]	PUNCT
admet-514	188	4	p.	p.	PROPN
admet-514	188	5	wu	wu	PROPN
admet-514	188	6	,	,	PUNCT
admet-514	188	7	t.e	t.e	PROPN
admet-514	188	8	.	.	PROPN
admet-514	188	9	nielsen	nielsen	PROPN
admet-514	188	10	,	,	PUNCT
admet-514	188	11	m.h	m.h	PROPN
admet-514	188	12	.	.	PROPN
admet-514	188	13	clausen	clausen	PROPN
admet-514	188	14	.	.	PUNCT
admet-514	189	1	fda	fda	PROPN
admet-514	189	2	-	-	PUNCT
admet-514	189	3	approved	approve	VERB
admet-514	189	4	small	small	ADJ
admet-514	189	5	-	-	PUNCT
admet-514	189	6	molecule	molecule	NOUN
admet-514	189	7	kinase	kinase	NOUN
admet-514	189	8	inhibitors	inhibitor	NOUN
admet-514	189	9	.	.	PUNCT
admet-514	190	1	trends	trend	NOUN
admet-514	190	2	in	in	ADP
admet-514	190	3	pharmacological	pharmacological	ADJ
admet-514	190	4	sciences	science	NOUN
admet-514	190	5	36	36	NUM
admet-514	190	6	(	(	PUNCT
admet-514	190	7	2015	2015	NUM
admet-514	190	8	)	)	PUNCT
admet-514	190	9	422–439	422–439	NUM
admet-514	190	10	.	.	PUNCT
admet-514	191	1	[	[	X
admet-514	191	2	4	4	NUM
admet-514	191	3	]	]	X
admet-514	191	4	m.p	m.p	PROPN
admet-514	191	5	.	.	PROPN
admet-514	191	6	pinto	pinto	PROPN
admet-514	191	7	,	,	PUNCT
admet-514	191	8	g.	g.	PROPN
admet-514	191	9	i.	i.	PROPN
admet-514	191	10	owen	owen	PROPN
admet-514	191	11	,	,	PUNCT
admet-514	191	12	i.	i.	PROPN
admet-514	191	13	retamal	retamal	PROPN
admet-514	191	14	,	,	PUNCT
admet-514	191	15	m.	m.	NOUN
admet-514	191	16	garrido	garrido	PROPN
admet-514	191	17	.	.	PUNCT
admet-514	192	1	angiogenesis	angiogenesis	NOUN
admet-514	192	2	inhibitors	inhibitor	NOUN
admet-514	192	3	in	in	ADP
admet-514	192	4	early	early	ADJ
admet-514	192	5	development	development	NOUN
admet-514	192	6	for	for	ADP
admet-514	192	7	gastric	gastric	ADJ
admet-514	192	8	cancer	cancer	NOUN
admet-514	192	9	.	.	PUNCT
admet-514	193	1	expert	expert	ADJ
admet-514	193	2	opinion	opinion	NOUN
admet-514	193	3	on	on	ADP
admet-514	193	4	investigational	investigational	ADJ
admet-514	193	5	drugs	drug	NOUN
admet-514	193	6	26	26	NUM
admet-514	193	7	(	(	PUNCT
admet-514	193	8	2017	2017	NUM
admet-514	193	9	)	)	PUNCT
admet-514	193	10	1007–1017	1007–1017	NUM
admet-514	193	11	.	.	PUNCT
admet-514	194	1	[	[	X
admet-514	194	2	5	5	NUM
admet-514	194	3	]	]	X
admet-514	194	4	c.g	c.g	PROPN
admet-514	194	5	.	.	PROPN
admet-514	194	6	da	da	PROPN
admet-514	194	7	silva	silva	PROPN
admet-514	194	8	,	,	PUNCT
admet-514	194	9	r.	r.	PROPN
admet-514	194	10	j.	j.	PROPN
admet-514	194	11	honeywell	honeywell	PROPN
admet-514	194	12	,	,	PUNCT
admet-514	194	13	h.	h.	PROPN
admet-514	194	14	dekker	dekker	PROPN
admet-514	194	15	,	,	PUNCT
admet-514	194	16	g.	g.	PROPN
admet-514	194	17	j.	j.	PROPN
admet-514	194	18	peters	peters	PROPN
admet-514	194	19	.	.	PUNCT
admet-514	195	1	physicochemical	physicochemical	ADJ
admet-514	195	2	properties	property	NOUN
admet-514	195	3	of	of	ADP
admet-514	195	4	novel	novel	ADJ
admet-514	195	5	protein	protein	NOUN
admet-514	195	6	kinase	kinase	NOUN
admet-514	195	7	inhibitors	inhibitor	NOUN
admet-514	195	8	in	in	ADP
admet-514	195	9	relation	relation	NOUN
admet-514	195	10	to	to	ADP
admet-514	195	11	their	their	PRON
admet-514	195	12	substrate	substrate	NOUN
admet-514	195	13	specificity	specificity	NOUN
admet-514	195	14	for	for	ADP
admet-514	195	15	drug	drug	NOUN
admet-514	195	16	transporters	transporter	NOUN
admet-514	195	17	.	.	PUNCT
admet-514	196	1	expert	expert	NOUN
admet-514	196	2	opin	opin	NOUN
admet-514	196	3	.	.	PUNCT
admet-514	197	1	drug	drug	NOUN
admet-514	197	2	metab	metab	NOUN
admet-514	197	3	.	.	PUNCT
admet-514	198	1	toxicol	toxicol	PROPN
admet-514	198	2	.	.	PUNCT
admet-514	199	1	11	11	NUM
admet-514	199	2	(	(	PUNCT
admet-514	199	3	2015	2015	NUM
admet-514	199	4	)	)	PUNCT
admet-514	199	5	703	703	NUM
admet-514	199	6	-	-	SYM
admet-514	199	7	717	717	NUM
admet-514	199	8	.	.	PUNCT
admet-514	200	1	[	[	X
admet-514	200	2	6	6	NUM
admet-514	200	3	]	]	X
admet-514	200	4	n.	n.	PROPN
admet-514	200	5	van	van	PROPN
admet-514	200	6	der	der	PROPN
admet-514	200	7	steen	steen	PROPN
admet-514	200	8	,	,	PUNCT
admet-514	200	9	c.	c.	PROPN
admet-514	200	10	caparello	caparello	PROPN
admet-514	200	11	,	,	PUNCT
admet-514	200	12	c.	c.	PROPN
admet-514	200	13	rolfo	rolfo	PROPN
admet-514	200	14	,	,	PUNCT
admet-514	200	15	p.	p.	NOUN
admet-514	200	16	pauwels	pauwel	NOUN
admet-514	200	17	,	,	PUNCT
admet-514	200	18	g.j	g.j	PROPN
admet-514	200	19	.	.	PROPN
admet-514	200	20	peters	peters	PROPN
admet-514	200	21	,	,	PUNCT
admet-514	200	22	e.	e.	PROPN
admet-514	200	23	giovannetti	giovannetti	PROPN
admet-514	200	24	.	.	PUNCT
admet-514	201	1	new	new	ADJ
admet-514	201	2	developments	development	NOUN
admet-514	201	3	in	in	ADP
admet-514	201	4	the	the	DET
admet-514	201	5	management	management	NOUN
admet-514	201	6	of	of	ADP
admet-514	201	7	non	non	ADJ
admet-514	201	8	-	-	ADJ
admet-514	201	9	small	small	ADJ
admet-514	201	10	-	-	PUNCT
admet-514	201	11	cell	cell	NOUN
admet-514	201	12	lung	lung	NOUN
admet-514	201	13	cancer	cancer	NOUN
admet-514	201	14	,	,	PUNCT
admet-514	201	15	focus	focus	VERB
admet-514	201	16	on	on	ADP
admet-514	201	17	rociletinib	rociletinib	NOUN
admet-514	201	18	:	:	PUNCT
admet-514	201	19	what	what	PRON
admet-514	201	20	went	go	VERB
admet-514	201	21	wrong	wrong	ADJ
admet-514	201	22	?	?	PUNCT
admet-514	202	1	oncotargets	oncotarget	NOUN
admet-514	202	2	and	and	CCONJ
admet-514	202	3	therapy	therapy	NOUN
admet-514	202	4	9	9	NUM
admet-514	202	5	(	(	PUNCT
admet-514	202	6	2016	2016	NUM
admet-514	202	7	)	)	PUNCT
admet-514	202	8	6065–6074	6065–6074	NUM
admet-514	202	9	.	.	PUNCT
admet-514	203	1	[	[	X
admet-514	203	2	7	7	X
admet-514	203	3	]	]	X
admet-514	203	4	k.j	k.j	PROPN
admet-514	203	5	.	.	PROPN
admet-514	203	6	gotink	gotink	PROPN
admet-514	203	7	,	,	PUNCT
admet-514	203	8	h.j	h.j	PROPN
admet-514	203	9	.	.	PROPN
admet-514	203	10	broxterman	broxterman	PROPN
admet-514	203	11	,	,	PUNCT
admet-514	203	12	m.	m.	NOUN
admet-514	203	13	labots	labots	PROPN
admet-514	203	14	,	,	PUNCT
admet-514	203	15	r.r	r.r	PROPN
admet-514	203	16	.	.	PROPN
admet-514	203	17	de	de	PROPN
admet-514	203	18	haas	haas	PROPN
admet-514	203	19	,	,	PUNCT
admet-514	203	20	h.	h.	PROPN
admet-514	203	21	dekker	dekker	PROPN
admet-514	203	22	,	,	PUNCT
admet-514	203	23	r.j	r.j	PROPN
admet-514	203	24	.	.	PROPN
admet-514	203	25	honeywell	honeywell	PROPN
admet-514	203	26	,	,	PUNCT
admet-514	203	27	m.a	m.a	PROPN
admet-514	203	28	.	.	PROPN
admet-514	203	29	rudek	rudek	PROPN
admet-514	203	30	,	,	PUNCT
admet-514	203	31	l.v	l.v	PROPN
admet-514	203	32	.	.	PROPN
admet-514	203	33	beerepoot	beerepoot	PROPN
admet-514	203	34	,	,	PUNCT
admet-514	203	35	r.j	r.j	PROPN
admet-514	203	36	.	.	PROPN
admet-514	203	37	musetrs	musetrs	PROPN
admet-514	203	38	,	,	PUNCT
admet-514	203	39	g.	g.	PROPN
admet-514	203	40	jansen	jansen	PROPN
admet-514	203	41	,	,	PUNCT
admet-514	203	42	a.w	a.w	PROPN
admet-514	203	43	.	.	PROPN
admet-514	203	44	griffioen	griffioen	PROPN
admet-514	203	45	,	,	PUNCT
admet-514	203	46	y.g	y.g	PROPN
admet-514	203	47	.	.	PROPN
admet-514	203	48	assaraf	assaraf	PROPN
admet-514	203	49	,	,	PUNCT
admet-514	203	50	r.	r.	PROPN
admet-514	203	51	pili	pili	PROPN
admet-514	203	52	,	,	PUNCT
admet-514	203	53	g.j	g.j	PROPN
admet-514	203	54	.	.	PROPN
admet-514	203	55	peters	peters	PROPN
admet-514	203	56	,	,	PUNCT
admet-514	203	57	h.m.w	h.m.w	PROPN
admet-514	203	58	.	.	PROPN
admet-514	203	59	verheul	verheul	PROPN
admet-514	203	60	.	.	PUNCT
admet-514	204	1	lysosomal	lysosomal	ADJ
admet-514	204	2	sequestration	sequestration	NOUN
admet-514	204	3	of	of	ADP
admet-514	204	4	sunitinib	sunitinib	NOUN
admet-514	204	5	:	:	PUNCT
admet-514	204	6	a	a	DET
admet-514	204	7	novel	novel	ADJ
admet-514	204	8	mechanism	mechanism	NOUN
admet-514	204	9	of	of	ADP
admet-514	204	10	drug	drug	NOUN
admet-514	204	11	resistance	resistance	NOUN
admet-514	204	12	.	.	PUNCT
admet-514	205	1	clin	clin	PROPN
admet-514	205	2	.	.	PUNCT
admet-514	206	1	cancer	cancer	NOUN
admet-514	206	2	res	re	NOUN
admet-514	206	3	.	.	PROPN
admet-514	207	1	17	17	NUM
admet-514	207	2	(	(	PUNCT
admet-514	207	3	2011	2011	NUM
admet-514	207	4	)	)	PUNCT
admet-514	207	5	7337	7337	NUM
admet-514	207	6	-	-	SYM
admet-514	207	7	7346	7346	NUM
admet-514	207	8	.	.	PUNCT
admet-514	208	1	[	[	X
admet-514	208	2	8	8	X
admet-514	208	3	]	]	X
admet-514	208	4	e.	e.	PROPN
admet-514	208	5	giovannetti	giovannetti	PROPN
admet-514	208	6	,	,	PUNCT
admet-514	208	7	m.	m.	NOUN
admet-514	208	8	labots	labots	PROPN
admet-514	208	9	,	,	PUNCT
admet-514	208	10	h.	h.	PROPN
admet-514	208	11	dekker	dekker	PROPN
admet-514	208	12	,	,	PUNCT
admet-514	208	13	e.	e.	PROPN
admet-514	208	14	galvani	galvani	PROPN
admet-514	208	15	,	,	PUNCT
admet-514	208	16	j.s.w	j.s.w	NOUN
admet-514	208	17	.	.	PUNCT
admet-514	208	18	lind	lind	PROPN
admet-514	208	19	,	,	PUNCT
admet-514	208	20	r.	r.	PROPN
admet-514	208	21	sciarillo	sciarillo	PROPN
admet-514	208	22	,	,	PUNCT
admet-514	208	23	r.	r.	PROPN
admet-514	208	24	honeywell	honeywell	PROPN
admet-514	208	25	,	,	PUNCT
admet-514	208	26	e.f	e.f	PROPN
admet-514	208	27	.	.	PROPN
admet-514	208	28	smit	smit	PROPN
admet-514	208	29	,	,	PUNCT
admet-514	208	30	h.m.w	h.m.w	PROPN
admet-514	208	31	.	.	PROPN
admet-514	208	32	verheul	verheul	PROPN
admet-514	208	33	,	,	PUNCT
admet-514	208	34	g.j	g.j	PROPN
admet-514	208	35	.	.	PROPN
admet-514	208	36	peters	peters	PROPN
admet-514	208	37	.	.	PUNCT
admet-514	209	1	molecular	molecular	ADJ
admet-514	209	2	mechanisms	mechanism	NOUN
admet-514	209	3	and	and	CCONJ
admet-514	209	4	modulation	modulation	NOUN
admet-514	209	5	of	of	ADP
admet-514	209	6	key	key	ADJ
admet-514	209	7	pathways	pathway	NOUN
admet-514	209	8	underlying	underlie	VERB
admet-514	209	9	the	the	DET
admet-514	209	10	synergistic	synergistic	ADJ
admet-514	209	11	interaction	interaction	NOUN
admet-514	209	12	of	of	ADP
admet-514	209	13	sorafenib	sorafenib	NOUN
admet-514	209	14	with	with	ADP
admet-514	209	15	erlotinib	erlotinib	NOUN
admet-514	209	16	in	in	ADP
admet-514	209	17	non	non	ADJ
admet-514	209	18	-	-	ADJ
admet-514	209	19	small	small	ADJ
admet-514	209	20	-	-	PUNCT
admet-514	209	21	cell	cell	NOUN
admet-514	209	22	-	-	PUNCT
admet-514	209	23	lung	lung	NOUN
admet-514	209	24	cancer	cancer	NOUN
admet-514	209	25	(	(	PUNCT
admet-514	209	26	nsclc	nsclc	NOUN
admet-514	209	27	)	)	PUNCT
admet-514	209	28	cells	cell	NOUN
admet-514	209	29	|	|	ADV
admet-514	209	30	benthamscience	benthamscience	NOUN
admet-514	209	31	.	.	PUNCT
admet-514	210	1	curr	curr	PROPN
admet-514	210	2	.	.	PUNCT
admet-514	211	1	pharm	pharm	PROPN
admet-514	211	2	.	.	PUNCT
admet-514	212	1	des	des	PROPN
admet-514	212	2	.	.	PROPN
admet-514	213	1	(	(	PUNCT
admet-514	213	2	2013	2013	NUM
admet-514	213	3	)	)	PUNCT
admet-514	214	1	927–939	927–939	NUM
admet-514	214	2	.	.	PUNCT
admet-514	215	1	[	[	X
admet-514	215	2	9	9	NUM
admet-514	215	3	]	]	X
admet-514	215	4	n.p	n.p	PROPN
admet-514	215	5	.	.	PROPN
admet-514	215	6	van	van	PROPN
admet-514	215	7	erp	erp	PROPN
admet-514	215	8	,	,	PUNCT
admet-514	215	9	h.	h.	PROPN
admet-514	215	10	gelderblom	gelderblom	PROPN
admet-514	215	11	,	,	PUNCT
admet-514	215	12	h.-j	h.-j	PROPN
admet-514	215	13	.	.	PUNCT
admet-514	215	14	guchelaar	guchelaar	NOUN
admet-514	215	15	.	.	PUNCT
admet-514	216	1	clinical	clinical	ADJ
admet-514	216	2	pharmacokinetics	pharmacokinetic	NOUN
admet-514	216	3	of	of	ADP
admet-514	216	4	tyrosine	tyrosine	NOUN
admet-514	216	5	kinase	kinase	PROPN
admet-514	216	6	inhibitors	inhibitor	NOUN
admet-514	216	7	.	.	PUNCT
admet-514	217	1	cancer	cancer	NOUN
admet-514	217	2	treat	treat	NOUN
admet-514	217	3	rev	rev	VERB
admet-514	217	4	35	35	NUM
admet-514	217	5	(	(	PUNCT
admet-514	217	6	2009	2009	NUM
admet-514	217	7	)	)	PUNCT
admet-514	217	8	692–706	692–706	NUM
admet-514	217	9	.	.	PUNCT
admet-514	218	1	[	[	X
admet-514	218	2	10	10	NUM
admet-514	218	3	]	]	PUNCT
admet-514	218	4	k.	k.	PROPN
admet-514	218	5	valko	valko	PROPN
admet-514	218	6	.	.	PUNCT
admet-514	219	1	bio	bio	PROPN
admet-514	219	2	-	-	ADJ
admet-514	219	3	mimetic	mimetic	ADJ
admet-514	219	4	chromatography	chromatography	NOUN
admet-514	219	5	to	to	PART
admet-514	219	6	predict	predict	VERB
admet-514	219	7	drug	drug	NOUN
admet-514	219	8	distribution	distribution	NOUN
admet-514	219	9	in	in	ADP
admet-514	219	10	vivo	vivo	NOUN
admet-514	219	11	.	.	PUNCT
admet-514	220	1	european	european	ADJ
admet-514	220	2	pharmaceutical	pharmaceutical	PROPN
admet-514	220	3	review	review	PROPN
admet-514	220	4	(	(	PUNCT
admet-514	220	5	2010	2010	NUM
admet-514	220	6	)	)	PUNCT
admet-514	220	7	.	.	PUNCT
admet-514	221	1	[	[	X
admet-514	221	2	11	11	NUM
admet-514	221	3	]	]	X
admet-514	221	4	a.d	a.d	PROPN
admet-514	221	5	.	.	PROPN
admet-514	221	6	adema	adema	PROPN
admet-514	221	7	,	,	PUNCT
admet-514	221	8	k.	k.	PROPN
admet-514	221	9	smid	smid	PROPN
admet-514	221	10	,	,	PUNCT
admet-514	221	11	n.	n.	PROPN
admet-514	221	12	losekoot	losekoot	PROPN
admet-514	221	13	,	,	PUNCT
admet-514	221	14	r.	r.	PROPN
admet-514	221	15	honeywell	honeywell	PROPN
admet-514	221	16	,	,	PUNCT
admet-514	221	17	h.m.w	h.m.w	PROPN
admet-514	221	18	.	.	PROPN
admet-514	221	19	verheul	verheul	PROPN
admet-514	221	20	,	,	PUNCT
admet-514	221	21	f.	f.	PROPN
admet-514	221	22	mihren	mihren	PROPN
admet-514	221	23	,	,	PUNCT
admet-514	221	24	m.l	m.l	PROPN
admet-514	221	25	.	.	PROPN
admet-514	221	26	sandvold	sandvold	PROPN
admet-514	221	27	,	,	PUNCT
admet-514	221	28	g.j	g.j	PROPN
admet-514	221	29	.	.	PROPN
admet-514	221	30	peters	peters	PROPN
admet-514	221	31	.	.	PUNCT
admet-514	221	32	metabolism	metabolism	NOUN
admet-514	221	33	and	and	CCONJ
admet-514	221	34	accumulation	accumulation	NOUN
admet-514	221	35	of	of	ADP
admet-514	221	36	the	the	DET
admet-514	221	37	lipophilic	lipophilic	ADJ
admet-514	221	38	deoxynucleoside	deoxynucleoside	NOUN
admet-514	221	39	analogs	analogs	PROPN
admet-514	221	40	elacytarabine	elacytarabine	NOUN
admet-514	221	41	and	and	CCONJ
admet-514	221	42	cp-4126	cp-4126	NOUN
admet-514	221	43	.	.	PUNCT
admet-514	222	1	invest	invest	VERB
admet-514	222	2	.	.	PUNCT
admet-514	223	1	new	new	ADJ
admet-514	223	2	drugs	drug	NOUN
admet-514	223	3	30	30	NUM
admet-514	223	4	(	(	PUNCT
admet-514	223	5	2012	2012	NUM
admet-514	223	6	)	)	PUNCT
admet-514	223	7	1908–1916	1908–1916	NUM
admet-514	223	8	.	.	PUNCT
admet-514	224	1	[	[	X
admet-514	224	2	12	12	NUM
admet-514	224	3	]	]	X
admet-514	224	4	r.j	r.j	PROPN
admet-514	224	5	.	.	PROPN
admet-514	224	6	honeywell	honeywell	PROPN
admet-514	224	7	,	,	PUNCT
admet-514	224	8	d.	d.	PROPN
admet-514	224	9	sarkisjan	sarkisjan	PROPN
admet-514	224	10	,	,	PUNCT
admet-514	224	11	i.	i.	PROPN
admet-514	224	12	kathmann	kathmann	PROPN
admet-514	224	13	,	,	PUNCT
admet-514	224	14	m.h	m.h	PROPN
admet-514	224	15	.	.	PROPN
admet-514	224	16	kristensen	kristensen	PROPN
admet-514	224	17	,	,	PUNCT
admet-514	224	18	g.j	g.j	PROPN
admet-514	224	19	.	.	PROPN
admet-514	224	20	peters	peters	PROPN
admet-514	224	21	.	.	PUNCT
admet-514	225	1	sensitive	sensitive	ADJ
admet-514	225	2	liquid	liquid	ADJ
admet-514	225	3	chromatography	chromatography	NOUN
admet-514	225	4	mass	mass	NOUN
admet-514	225	5	spectrometry	spectrometry	NOUN
admet-514	225	6	(	(	PUNCT
admet-514	225	7	lc	lc	PROPN
admet-514	225	8	-	-	PUNCT
admet-514	225	9	ms	ms	NOUN
admet-514	225	10	)	)	PUNCT
admet-514	225	11	assay	assay	PROPN
admet-514	225	12	reveals	reveal	VERB
admet-514	225	13	novel	novel	ADJ
admet-514	225	14	insights	insight	NOUN
admet-514	225	15	on	on	ADP
admet-514	225	16	dna	dna	PROPN
admet-514	225	17	methylation	methylation	NOUN
admet-514	225	18	and	and	CCONJ
admet-514	225	19	incorporation	incorporation	NOUN
admet-514	225	20	of	of	ADP
admet-514	225	21	gemcitabine	gemcitabine	NOUN
admet-514	225	22	,	,	PUNCT
admet-514	225	23	its	its	PRON
admet-514	225	24	metabolite	metabolite	NOUN
admet-514	225	25	difluorodeoxyuridine	difluorodeoxyuridine	NOUN
admet-514	225	26	,	,	PUNCT
admet-514	225	27	deoxyuridine	deoxyuridine	NOUN
admet-514	225	28	,	,	PUNCT
admet-514	225	29	and	and	CCONJ
admet-514	225	30	rx-3117	rx-3117	VERB
admet-514	225	31	into	into	ADP
admet-514	225	32	dna	dna	PROPN
admet-514	225	33	.	.	PUNCT
admet-514	226	1	nucleosides	nucleoside	NOUN
admet-514	226	2	,	,	PUNCT
admet-514	226	3	nucleotides	nucleotide	NOUN
admet-514	226	4	and	and	CCONJ
admet-514	226	5	nucleic	nucleic	ADJ
admet-514	226	6	acids	acid	NOUN
admet-514	226	7	35	35	NUM
admet-514	226	8	(	(	PUNCT
admet-514	226	9	2016	2016	NUM
admet-514	226	10	)	)	PUNCT
admet-514	226	11	652	652	NUM
admet-514	226	12	-	-	SYM
admet-514	226	13	662	662	NUM
admet-514	226	14	.	.	PUNCT
admet-514	227	1	[	[	X
admet-514	227	2	13	13	NUM
admet-514	227	3	]	]	X
admet-514	227	4	r.	r.	PROPN
admet-514	227	5	honeywell	honeywell	PROPN
admet-514	227	6	,	,	PUNCT
admet-514	227	7	c.	c.	PROPN
admet-514	227	8	fatmawati	fatmawati	PROPN
admet-514	227	9	,	,	PUNCT
admet-514	227	10	m.	m.	NOUN
admet-514	227	11	buddha	buddha	PROPN
admet-514	227	12	,	,	PUNCT
admet-514	227	13	s.	s.	PROPN
admet-514	227	14	hitzerd	hitzerd	PROPN
admet-514	227	15	,	,	PUNCT
admet-514	227	16	i.	i.	PROPN
admet-514	227	17	kathman	kathman	PROPN
admet-514	227	18	,	,	PUNCT
admet-514	227	19	g.j	g.j	PROPN
admet-514	227	20	.	.	PROPN
admet-514	227	21	peters	peters	PROPN
admet-514	227	22	.	.	PUNCT
admet-514	228	1	adaptation	adaptation	NOUN
admet-514	228	2	of	of	ADP
admet-514	228	3	a	a	DET
admet-514	228	4	human	human	ADJ
admet-514	228	5	gut	gut	NOUN
admet-514	228	6	epithelial	epithelial	ADJ
admet-514	228	7	model	model	NOUN
admet-514	228	8	in	in	ADP
admet-514	228	9	relation	relation	NOUN
admet-514	228	10	to	to	ADP
admet-514	228	11	the	the	DET
admet-514	228	12	assessment	assessment	NOUN
admet-514	228	13	of	of	ADP
admet-514	228	14	clinical	clinical	ADJ
admet-514	228	15	pharmacokinetic	pharmacokinetic	ADJ
admet-514	228	16	parameters	parameter	NOUN
admet-514	228	17	for	for	ADP
admet-514	228	18	selected	select	VERB
admet-514	228	19	tyrosine	tyrosine	NOUN
admet-514	228	20	kinase	kinase	PROPN
admet-514	228	21	inhibitors	inhibitor	NOUN
admet-514	228	22	.	.	PUNCT
admet-514	229	1	admet	admet	PROPN
admet-514	229	2	dmpk	dmpk	PROPN
admet-514	229	3	3	3	NUM
admet-514	229	4	(	(	PUNCT
admet-514	229	5	2015	2015	NUM
admet-514	229	6	)	)	PUNCT
admet-514	229	7	51–67	51–67	NUM
admet-514	229	8	.	.	PUNCT
admet-514	230	1	[	[	X
admet-514	230	2	14	14	NUM
admet-514	230	3	]	]	PUNCT
admet-514	230	4	t.	t.	NOUN
admet-514	230	5	rabilloud	rabilloud	PROPN
admet-514	230	6	,	,	PUNCT
admet-514	230	7	c.	c.	PROPN
admet-514	230	8	adessi	adessi	PROPN
admet-514	230	9	,	,	PUNCT
admet-514	230	10	a.	a.	PROPN
admet-514	230	11	giraudel	giraudel	PROPN
admet-514	230	12	,	,	PUNCT
admet-514	230	13	j.	j.	PROPN
admet-514	230	14	lunardi	lunardi	PROPN
admet-514	230	15	.	.	PUNCT
admet-514	231	1	improvement	improvement	NOUN
admet-514	231	2	of	of	ADP
admet-514	231	3	the	the	DET
admet-514	231	4	solubilization	solubilization	NOUN
admet-514	231	5	of	of	ADP
admet-514	231	6	proteins	protein	NOUN
admet-514	231	7	in	in	ADP
admet-514	231	8	twodimensional	twodimensional	ADJ
admet-514	231	9	electrophoresis	electrophoresis	NOUN
admet-514	231	10	with	with	ADP
admet-514	231	11	immobilized	immobilized	ADJ
admet-514	231	12	ph	ph	ADJ
admet-514	231	13	gradients	gradient	NOUN
admet-514	231	14	.	.	PUNCT
admet-514	232	1	electrophoresis	electrophoresis	NOUN
admet-514	232	2	18	18	NUM
admet-514	232	3	(	(	PUNCT
admet-514	232	4	1997	1997	NUM
admet-514	232	5	)	)	PUNCT
admet-514	233	1	307–316	307–316	NUM
admet-514	233	2	.	.	PUNCT
admet-514	234	1	richard	richard	PROPN
admet-514	234	2	honeywell	honeywell	PROPN
admet-514	234	3	et	et	PROPN
admet-514	234	4	al	al	PROPN
admet-514	234	5	.	.	PROPN
admet-514	234	6	admet	admet	PROPN
admet-514	234	7	&	&	CCONJ
admet-514	234	8	dmpk	dmpk	PROPN
admet-514	234	9	6(3	6(3	PROPN
admet-514	234	10	)	)	PUNCT
admet-514	234	11	(	(	PUNCT
admet-514	234	12	2018	2018	NUM
admet-514	234	13	)	)	PUNCT
admet-514	234	14	258	258	NUM
admet-514	234	15	-	-	SYM
admet-514	234	16	266	266	NUM
admet-514	234	17	266	266	NUM
admet-514	234	18	[	[	X
admet-514	234	19	15	15	NUM
admet-514	234	20	]	]	X
admet-514	234	21	t.w.h	t.w.h	PROPN
admet-514	234	22	.	.	PROPN
admet-514	234	23	backman	backman	PROPN
admet-514	234	24	,	,	PUNCT
admet-514	234	25	y.	y.	PROPN
admet-514	234	26	cao	cao	PROPN
admet-514	234	27	,	,	PUNCT
admet-514	234	28	t.	t.	NOUN
admet-514	234	29	girke	girke	NOUN
admet-514	234	30	.	.	PUNCT
admet-514	235	1	chemmine	chemmine	NOUN
admet-514	235	2	tools	tool	NOUN
admet-514	235	3	:	:	PUNCT
admet-514	235	4	an	an	DET
admet-514	235	5	online	online	ADJ
admet-514	235	6	service	service	NOUN
admet-514	235	7	for	for	ADP
admet-514	235	8	analyzing	analyze	VERB
admet-514	235	9	and	and	CCONJ
admet-514	235	10	clustering	cluster	VERB
admet-514	235	11	small	small	ADJ
admet-514	235	12	molecules	molecule	NOUN
admet-514	235	13	.	.	PUNCT
admet-514	236	1	nucleic	nucleic	ADJ
admet-514	236	2	acids	acid	NOUN
admet-514	236	3	res	re	NOUN
admet-514	236	4	.	.	PUNCT
admet-514	237	1	39	39	NUM
admet-514	237	2	(	(	PUNCT
admet-514	237	3	2011	2011	NUM
admet-514	237	4	)	)	PUNCT
admet-514	237	5	w486	w486	PROPN
admet-514	237	6	–	–	PUNCT
admet-514	237	7	w491	w491	PROPN
admet-514	237	8	.	.	PUNCT
admet-514	238	1	[	[	X
admet-514	238	2	16	16	NUM
admet-514	238	3	]	]	PUNCT
admet-514	238	4	k.	k.	PROPN
admet-514	238	5	azijli	azijli	PROPN
admet-514	238	6	,	,	PUNCT
admet-514	238	7	k.j	k.j	PROPN
admet-514	238	8	.	.	PROPN
admet-514	238	9	gotink	gotink	PROPN
admet-514	238	10	,	,	PUNCT
admet-514	238	11	h.m	h.m	PROPN
admet-514	238	12	.	.	PROPN
admet-514	238	13	verheul	verheul	PROPN
admet-514	238	14	.	.	PUNCT
admet-514	239	1	the	the	DET
admet-514	239	2	potential	potential	ADJ
admet-514	239	3	role	role	NOUN
admet-514	239	4	of	of	ADP
admet-514	239	5	lysosomal	lysosomal	ADJ
admet-514	239	6	sequestration	sequestration	NOUN
admet-514	239	7	in	in	ADP
admet-514	239	8	sunitinib	sunitinib	NOUN
admet-514	239	9	resistance	resistance	NOUN
admet-514	239	10	of	of	ADP
admet-514	239	11	renal	renal	ADJ
admet-514	239	12	cell	cell	NOUN
admet-514	239	13	cancer	cancer	NOUN
admet-514	239	14	.	.	PUNCT
admet-514	240	1	j.	j.	PROPN
admet-514	240	2	kidney	kidney	PROPN
admet-514	240	3	cancer	cancer	PROPN
admet-514	240	4	vhl	vhl	PROPN
admet-514	240	5	2	2	NUM
admet-514	240	6	(	(	PUNCT
admet-514	240	7	2016	2016	NUM
admet-514	240	8	)	)	PUNCT
admet-514	240	9	195	195	NUM
admet-514	240	10	-	-	SYM
admet-514	240	11	203	203	NUM
admet-514	240	12	.	.	PUNCT
admet-514	241	1	[	[	X
admet-514	241	2	17	17	NUM
admet-514	241	3	]	]	X
admet-514	241	4	b.	b.	PROPN
admet-514	241	5	zhitomirsky	zhitomirsky	PROPN
admet-514	241	6	,	,	PUNCT
admet-514	241	7	y.g	y.g	PROPN
admet-514	241	8	.	.	PROPN
admet-514	241	9	assaraf	assaraf	PROPN
admet-514	241	10	.	.	PUNCT
admet-514	242	1	lysosomes	lysosome	NOUN
admet-514	242	2	as	as	ADP
admet-514	242	3	mediators	mediator	NOUN
admet-514	242	4	of	of	ADP
admet-514	242	5	drug	drug	NOUN
admet-514	242	6	resistance	resistance	NOUN
admet-514	242	7	in	in	ADP
admet-514	242	8	cancer	cancer	NOUN
admet-514	242	9	.	.	PUNCT
admet-514	243	1	drug	drug	NOUN
admet-514	243	2	resist	resist	NOUN
admet-514	243	3	.	.	PUNCT
admet-514	244	1	updat	updat	PROPN
admet-514	244	2	.	.	PROPN
admet-514	245	1	24	24	NUM
admet-514	245	2	(	(	PUNCT
admet-514	245	3	2016	2016	NUM
admet-514	245	4	)	)	PUNCT
admet-514	245	5	23–33	23–33	NUM
admet-514	245	6	.	.	PUNCT
admet-514	246	1	[	[	X
admet-514	246	2	18	18	NUM
admet-514	246	3	]	]	X
admet-514	246	4	b.	b.	PROPN
admet-514	246	5	zhitomirsky	zhitomirsky	PROPN
admet-514	246	6	,	,	PUNCT
admet-514	246	7	y.g	y.g	PROPN
admet-514	246	8	.	.	PROPN
admet-514	246	9	assaraf	assaraf	PROPN
admet-514	246	10	.	.	PUNCT
admet-514	247	1	lysosomal	lysosomal	ADJ
admet-514	247	2	sequestration	sequestration	NOUN
admet-514	247	3	of	of	ADP
admet-514	247	4	hydrophobic	hydrophobic	NOUN
admet-514	247	5	weak	weak	ADJ
admet-514	247	6	base	base	NOUN
admet-514	247	7	chemotherapeutics	chemotherapeutic	NOUN
admet-514	247	8	triggers	trigger	VERB
admet-514	247	9	lysosomal	lysosomal	ADJ
admet-514	247	10	biogenesis	biogenesis	NOUN
admet-514	247	11	and	and	CCONJ
admet-514	247	12	lysosome	lysosome	NOUN
admet-514	247	13	-	-	PUNCT
admet-514	247	14	dependent	dependent	ADJ
admet-514	247	15	cancer	cancer	NOUN
admet-514	247	16	multidrug	multidrug	NOUN
admet-514	247	17	resistance	resistance	NOUN
admet-514	247	18	.	.	PUNCT
admet-514	248	1	oncotarget	oncotarget	NOUN
admet-514	248	2	6	6	NUM
admet-514	248	3	(	(	PUNCT
admet-514	248	4	2015	2015	NUM
admet-514	248	5	)	)	PUNCT
admet-514	248	6	1143–1156	1143–1156	NUM
admet-514	248	7	.	.	PUNCT
admet-514	249	1	[	[	X
admet-514	249	2	19	19	NUM
admet-514	249	3	]	]	X
admet-514	249	4	r.j	r.j	PROPN
admet-514	249	5	.	.	PROPN
admet-514	249	6	honeywell	honeywell	PROPN
admet-514	249	7	,	,	PUNCT
admet-514	249	8	s.	s.	PROPN
admet-514	249	9	hitzerd	hitzerd	PROPN
admet-514	249	10	,	,	PUNCT
admet-514	249	11	i.	i.	PROPN
admet-514	249	12	kathmann	kathmann	PROPN
admet-514	249	13	,	,	PUNCT
admet-514	249	14	g.	g.	PROPN
admet-514	249	15	j.	j.	PROPN
admet-514	249	16	peters	peters	PROPN
admet-514	249	17	.	.	PUNCT
admet-514	250	1	transport	transport	NOUN
admet-514	250	2	of	of	ADP
admet-514	250	3	six	six	NUM
admet-514	250	4	tyrosine	tyrosine	NOUN
admet-514	250	5	kinase	kinase	NOUN
admet-514	250	6	inhibitors	inhibitor	NOUN
admet-514	250	7	:	:	PUNCT
admet-514	250	8	active	active	ADJ
admet-514	250	9	or	or	CCONJ
admet-514	250	10	passive	passive	ADJ
admet-514	250	11	?	?	PUNCT
admet-514	251	1	admet	admet	PROPN
admet-514	251	2	dmpk	dmpk	NOUN
admet-514	251	3	4	4	NUM
admet-514	251	4	(	(	PUNCT
admet-514	251	5	2016	2016	NUM
admet-514	251	6	)	)	PUNCT
admet-514	251	7	23	23	NUM
admet-514	251	8	-	-	SYM
admet-514	251	9	34	34	NUM
admet-514	251	10	.	.	PUNCT
admet-514	252	1	[	[	X
admet-514	252	2	20	20	NUM
admet-514	252	3	]	]	X
admet-514	252	4	c.	c.	PROPN
admet-514	252	5	neul	neul	PROPN
admet-514	252	6	,	,	PUNCT
admet-514	252	7	e.	e.	PROPN
admet-514	252	8	schaeffeler	schaeffeler	PROPN
admet-514	252	9	,	,	PUNCT
admet-514	252	10	a.	a.	NOUN
admet-514	252	11	sparreboom	sparreboom	NOUN
admet-514	252	12	,	,	PUNCT
admet-514	252	13	s.	s.	PROPN
admet-514	252	14	laufer	laufer	PROPN
admet-514	252	15	,	,	PUNCT
admet-514	252	16	m.	m.	NOUN
admet-514	252	17	schwab	schwab	PROPN
admet-514	252	18	,	,	PUNCT
admet-514	252	19	a.t	a.t	PROPN
admet-514	252	20	.	.	PROPN
admet-514	252	21	nies	ny	NOUN
admet-514	252	22	.	.	PUNCT
admet-514	253	1	impact	impact	NOUN
admet-514	253	2	of	of	ADP
admet-514	253	3	membrane	membrane	NOUN
admet-514	253	4	drug	drug	NOUN
admet-514	253	5	transporters	transporter	NOUN
admet-514	253	6	on	on	ADP
admet-514	253	7	resistance	resistance	NOUN
admet-514	253	8	to	to	ADP
admet-514	253	9	small	small	ADJ
admet-514	253	10	-	-	PUNCT
admet-514	253	11	molecule	molecule	NOUN
admet-514	253	12	tyrosine	tyrosine	NOUN
admet-514	253	13	kinase	kinase	PROPN
admet-514	253	14	inhibitors	inhibitor	NOUN
admet-514	253	15	.	.	PUNCT
admet-514	254	1	trends	trend	NOUN
admet-514	254	2	in	in	ADP
admet-514	254	3	pharmacological	pharmacological	ADJ
admet-514	254	4	sciences	science	NOUN
admet-514	254	5	37	37	NUM
admet-514	254	6	(	(	PUNCT
admet-514	254	7	2016	2016	NUM
admet-514	254	8	)	)	PUNCT
admet-514	254	9	904–932	904–932	NUM
admet-514	254	10	.	.	PUNCT
admet-514	255	1	[	[	X
admet-514	255	2	21	21	NUM
admet-514	255	3	]	]	PUNCT
admet-514	255	4	m.	m.	NOUN
admet-514	255	5	galetti	galetti	PROPN
admet-514	255	6	,	,	PUNCT
admet-514	255	7	p.	p.	PROPN
admet-514	255	8	petronini	petronini	PROPN
admet-514	255	9	,	,	PUNCT
admet-514	255	10	c.	c.	PROPN
admet-514	255	11	fumarola	fumarola	PROPN
admet-514	255	12	,	,	PUNCT
admet-514	255	13	d.	d.	PROPN
admet-514	255	14	cretella	cretella	PROPN
admet-514	255	15	,	,	PUNCT
admet-514	255	16	s.	s.	PROPN
admet-514	255	17	la	la	PROPN
admet-514	255	18	monica	monica	PROPN
admet-514	255	19	,	,	PUNCT
admet-514	255	20	m.	m.	NOUN
admet-514	255	21	bonelli	bonelli	PROPN
admet-514	255	22	,	,	PUNCT
admet-514	255	23	a.	a.	NOUN
admet-514	255	24	cavazzoni	cavazzoni	PROPN
admet-514	255	25	,	,	PUNCT
admet-514	255	26	f.	f.	PROPN
admet-514	255	27	saccani	saccani	PROPN
admet-514	255	28	,	,	PUNCT
admet-514	255	29	c.	c.	PROPN
admet-514	255	30	caffarra	caffarra	PROPN
admet-514	255	31	,	,	PUNCT
admet-514	255	32	r.	r.	PROPN
admet-514	255	33	andreoli	andreoli	PROPN
admet-514	255	34	,	,	PUNCT
admet-514	255	35	a.	a.	PROPN
admet-514	255	36	mutti	mutti	PROPN
admet-514	255	37	,	,	PUNCT
admet-514	255	38	m.	m.	NOUN
admet-514	255	39	tiseo	tiseo	PROPN
admet-514	255	40	,	,	PUNCT
admet-514	255	41	a.	a.	NOUN
admet-514	255	42	ardizzoni	ardizzoni	NOUN
admet-514	255	43	,	,	PUNCT
admet-514	255	44	r.r	r.r	PROPN
admet-514	255	45	.	.	PROPN
admet-514	255	46	alfieri	alfieri	PROPN
admet-514	255	47	.	.	PUNCT
admet-514	256	1	effect	effect	NOUN
admet-514	256	2	of	of	ADP
admet-514	256	3	abcg2	abcg2	NOUN
admet-514	256	4	/	/	SYM
admet-514	256	5	bcrp	bcrp	NOUN
admet-514	256	6	expression	expression	NOUN
admet-514	256	7	on	on	ADP
admet-514	256	8	efflux	efflux	NOUN
admet-514	256	9	and	and	CCONJ
admet-514	256	10	uptake	uptake	ADJ
admet-514	256	11	of	of	ADP
admet-514	256	12	gefitinib	gefitinib	NOUN
admet-514	256	13	in	in	ADP
admet-514	256	14	nsclc	nsclc	NOUN
admet-514	256	15	cell	cell	NOUN
admet-514	256	16	lines	line	NOUN
admet-514	256	17	.	.	PUNCT
admet-514	257	1	plos	plos	PROPN
admet-514	257	2	one	one	NUM
admet-514	257	3	10	10	NUM
admet-514	257	4	(	(	PUNCT
admet-514	257	5	2015	2015	NUM
admet-514	257	6	)	)	PUNCT
admet-514	257	7	e0141795	e0141795	NUM
admet-514	257	8	.	.	PUNCT
admet-514	258	1	[	[	X
admet-514	258	2	22	22	NUM
admet-514	258	3	]	]	X
admet-514	258	4	e.i	e.i	PROPN
admet-514	258	5	.	.	PROPN
admet-514	258	6	zimmerman	zimmerman	PROPN
admet-514	258	7	,	,	PUNCT
admet-514	258	8	s.	s.	PROPN
admet-514	258	9	hu	hu	PROPN
admet-514	258	10	,	,	PUNCT
admet-514	258	11	j.l	j.l	PROPN
admet-514	258	12	.	.	PROPN
admet-514	258	13	roberts	roberts	PROPN
admet-514	258	14	,	,	PUNCT
admet-514	258	15	a.a	a.a	PROPN
admet-514	258	16	.	.	PROPN
admet-514	258	17	gibbson	gibbson	PROPN
admet-514	258	18	,	,	PUNCT
admet-514	258	19	s.j	s.j	PROPN
admet-514	258	20	.	.	PROPN
admet-514	258	21	orwick	orwick	PROPN
admet-514	258	22	,	,	PUNCT
admet-514	258	23	l.	l.	PROPN
admet-514	258	24	li	li	PROPN
admet-514	258	25	,	,	PUNCT
admet-514	258	26	a.	a.	NOUN
admet-514	258	27	sparreboom	sparreboom	PROPN
admet-514	258	28	,	,	PUNCT
admet-514	258	29	s.d	s.d	PROPN
admet-514	258	30	.	.	PROPN
admet-514	258	31	baker	baker	PROPN
admet-514	258	32	.	.	PUNCT
admet-514	259	1	contribution	contribution	NOUN
admet-514	259	2	of	of	ADP
admet-514	259	3	oatp1b1	oatp1b1	NOUN
admet-514	259	4	and	and	CCONJ
admet-514	259	5	oatp1b3	oatp1b3	NOUN
admet-514	259	6	to	to	ADP
admet-514	259	7	the	the	DET
admet-514	259	8	disposition	disposition	NOUN
admet-514	259	9	of	of	ADP
admet-514	259	10	sorafenib	sorafenib	NOUN
admet-514	259	11	and	and	CCONJ
admet-514	259	12	sorafenib	sorafenib	NOUN
admet-514	259	13	-	-	PUNCT
admet-514	259	14	glucuronide	glucuronide	NOUN
admet-514	259	15	.	.	PUNCT
admet-514	260	1	clin	clin	PROPN
admet-514	260	2	.	.	PUNCT
admet-514	261	1	cancer	cancer	NOUN
admet-514	261	2	res	re	NOUN
admet-514	261	3	.	.	PROPN
admet-514	262	1	19	19	NUM
admet-514	262	2	(	(	PUNCT
admet-514	262	3	2013	2013	NUM
admet-514	262	4	)	)	PUNCT
admet-514	262	5	1458–66	1458–66	NUM
admet-514	262	6	.	.	PUNCT
admet-514	263	1	[	[	X
admet-514	263	2	23	23	NUM
admet-514	263	3	]	]	X
admet-514	263	4	s.d	s.d	PROPN
admet-514	263	5	.	.	PROPN
admet-514	263	6	baker	baker	PROPN
admet-514	263	7	,	,	PUNCT
admet-514	263	8	s.	s.	PROPN
admet-514	263	9	hu	hu	PROPN
admet-514	263	10	.	.	PUNCT
admet-514	264	1	pharmacokinetic	pharmacokinetic	ADJ
admet-514	264	2	considerations	consideration	NOUN
admet-514	264	3	for	for	ADP
admet-514	264	4	new	new	ADJ
admet-514	264	5	targeted	target	VERB
admet-514	264	6	therapies	therapy	NOUN
admet-514	264	7	.	.	PUNCT
admet-514	265	1	clin	clin	PROPN
admet-514	265	2	.	.	PUNCT
admet-514	266	1	pharmacol	pharmacol	PROPN
admet-514	266	2	.	.	PUNCT
admet-514	267	1	ther	ther	PROPN
admet-514	267	2	.	.	PUNCT
admet-514	268	1	85	85	NUM
admet-514	268	2	(	(	PUNCT
admet-514	268	3	2009	2009	NUM
admet-514	268	4	)	)	PUNCT
admet-514	268	5	208–11	208–11	NOUN
admet-514	268	6	.	.	PUNCT
admet-514	269	1	©	©	PROPN
admet-514	269	2	2018	2018	NUM
admet-514	269	3	by	by	ADP
admet-514	269	4	the	the	DET
admet-514	269	5	authors	author	NOUN
admet-514	269	6	;	;	PUNCT
admet-514	270	1	licensee	licensee	PROPN
admet-514	270	2	iapc	iapc	PROPN
admet-514	270	3	,	,	PUNCT
admet-514	270	4	zagreb	zagreb	PROPN
admet-514	270	5	,	,	PUNCT
admet-514	270	6	croatia	croatia	PROPN
admet-514	270	7	.	.	PUNCT
admet-514	271	1	this	this	DET
admet-514	271	2	article	article	NOUN
admet-514	271	3	is	be	AUX
admet-514	271	4	an	an	DET
admet-514	271	5	open	open	ADJ
admet-514	271	6	-	-	PUNCT
admet-514	271	7	access	access	NOUN
admet-514	271	8	article	article	NOUN
admet-514	271	9	distributed	distribute	VERB
admet-514	271	10	under	under	ADP
admet-514	271	11	the	the	DET
admet-514	271	12	terms	term	NOUN
admet-514	271	13	and	and	CCONJ
admet-514	271	14	conditions	condition	NOUN
admet-514	271	15	of	of	ADP
admet-514	271	16	the	the	DET
admet-514	271	17	creative	creative	ADJ
admet-514	271	18	commons	common	NOUN
admet-514	271	19	attribution	attribution	NOUN
admet-514	271	20	license	license	NOUN
admet-514	271	21	(	(	PUNCT
admet-514	271	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-514	271	23	)	)	PUNCT
admet-514	271	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN