id	sid	tid	token	lemma	pos
admet-529	1	1	leveraging	leverage	VERB
admet-529	1	2	chromatography	chromatography	NOUN
admet-529	1	3	based	base	VERB
admet-529	1	4	physicochemical	physicochemical	ADJ
admet-529	1	5	properties	property	NOUN
admet-529	1	6	for	for	ADP
admet-529	1	7	efficient	efficient	ADJ
admet-529	1	8	drug	drug	NOUN
admet-529	1	9	design	design	NOUN
admet-529	1	10	doi	doi	NOUN
admet-529	1	11	:	:	PUNCT
admet-529	1	12	10.5599	10.5599	NUM
admet-529	1	13	/	/	SYM
admet-529	1	14	admet.529	admet.529	NOUN
admet-529	1	15	85	85	NUM
admet-529	1	16	admet	admet	X
admet-529	1	17	&	&	CCONJ
admet-529	1	18	dmpk	dmpk	PROPN
admet-529	1	19	6(2	6(2	NUM
admet-529	1	20	)	)	PUNCT
admet-529	1	21	(	(	PUNCT
admet-529	1	22	2018	2018	NUM
admet-529	1	23	)	)	PUNCT
admet-529	1	24	85	85	NUM
admet-529	1	25	-	-	SYM
admet-529	1	26	104	104	NUM
admet-529	1	27	;	;	PUNCT
admet-529	1	28	doi	doi	NOUN
admet-529	1	29	:	:	PUNCT
admet-529	1	30	http://dx.doi.org/10.5599/admet.529	http://dx.doi.org/10.5599/admet.529	ADV
admet-529	1	31	open	open	ADJ
admet-529	1	32	access	access	NOUN
admet-529	1	33	:	:	PUNCT
admet-529	1	34	issn	issn	PROPN
admet-529	1	35	:	:	PUNCT
admet-529	1	36	1848	1848	NUM
admet-529	1	37	-	-	SYM
admet-529	1	38	7718	7718	NUM
admet-529	1	39	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-529	1	40	review	review	NOUN
admet-529	1	41	leveraging	leverage	VERB
admet-529	1	42	chromatography	chromatography	NOUN
admet-529	1	43	based	base	VERB
admet-529	1	44	physicochemical	physicochemical	ADJ
admet-529	1	45	properties	property	NOUN
admet-529	1	46	for	for	ADP
admet-529	1	47	efficient	efficient	ADJ
admet-529	1	48	drug	drug	NOUN
admet-529	1	49	design	design	NOUN
admet-529	1	50	gilles	gilles	PROPN
admet-529	1	51	h.	h.	PROPN
admet-529	1	52	goetz	goetz	PROPN
admet-529	1	53	*	*	PROPN
admet-529	1	54	,	,	PUNCT
admet-529	1	55	marina	marina	PROPN
admet-529	1	56	shalaeva	shalaeva	VERB
admet-529	1	57	molecular	molecular	ADJ
admet-529	1	58	properties	property	NOUN
admet-529	1	59	group	group	NOUN
admet-529	1	60	,	,	PUNCT
admet-529	1	61	worldwide	worldwide	ADV
admet-529	1	62	medicinal	medicinal	ADJ
admet-529	1	63	chemistry	chemistry	NOUN
admet-529	1	64	,	,	PUNCT
admet-529	1	65	pfizer	pfizer	NOUN
admet-529	1	66	worldwide	worldwide	ADV
admet-529	1	67	research	research	PROPN
admet-529	1	68	&	&	CCONJ
admet-529	1	69	development	development	NOUN
admet-529	1	70	,	,	PUNCT
admet-529	1	71	pfizer	pfizer	PROPN
admet-529	1	72	,	,	PUNCT
admet-529	1	73	inc	inc	PROPN
admet-529	1	74	.	.	PROPN
admet-529	1	75	,	,	PUNCT
admet-529	1	76	groton	groton	PROPN
admet-529	1	77	,	,	PUNCT
admet-529	1	78	connecticut	connecticut	PROPN
admet-529	1	79	06340	06340	NUM
admet-529	1	80	,	,	PUNCT
admet-529	1	81	united	united	PROPN
admet-529	1	82	states	states	PROPN
admet-529	1	83	*	*	PUNCT
admet-529	1	84	corresponding	correspond	VERB
admet-529	1	85	author	author	NOUN
admet-529	1	86	e	e	NOUN
admet-529	1	87	-	-	NOUN
admet-529	1	88	mail	mail	NOUN
admet-529	1	89	:	:	PUNCT
admet-529	2	1	gilles.h.goetz@pfizer.com	gilles.h.goetz@pfizer.com	PROPN
admet-529	2	2	;	;	PUNCT
admet-529	2	3	tel	tel	PROPN
admet-529	2	4	.	.	PUNCT
admet-529	2	5	:	:	PUNCT
admet-529	3	1	+1	+1	PROPN
admet-529	3	2	-	-	PUNCT
admet-529	3	3	860	860	NUM
admet-529	3	4	-	-	PUNCT
admet-529	3	5	715	715	NUM
admet-529	3	6	-	-	SYM
admet-529	3	7	6311	6311	NUM
admet-529	3	8	received	receive	VERB
admet-529	3	9	:	:	PUNCT
admet-529	3	10	march	march	PROPN
admet-529	3	11	28	28	NUM
admet-529	3	12	,	,	PUNCT
admet-529	3	13	2018	2018	NUM
admet-529	3	14	;	;	PUNCT
admet-529	3	15	revised	revise	VERB
admet-529	3	16	:	:	PUNCT
admet-529	3	17	may	may	AUX
admet-529	3	18	26	26	NUM
admet-529	3	19	,	,	PUNCT
admet-529	3	20	2018	2018	NUM
admet-529	3	21	;	;	PUNCT
admet-529	3	22	available	available	ADJ
admet-529	3	23	online	online	ADV
admet-529	3	24	:	:	PUNCT
admet-529	3	25	june	june	PROPN
admet-529	3	26	04	04	NUM
admet-529	3	27	,	,	PUNCT
admet-529	3	28	2018	2018	NUM
admet-529	3	29	abstract	abstract	ADJ
admet-529	3	30	applications	application	NOUN
admet-529	3	31	of	of	ADP
admet-529	3	32	chromatography	chromatography	NOUN
admet-529	3	33	derived	derive	VERB
admet-529	3	34	lipophilicity	lipophilicity	NOUN
admet-529	3	35	,	,	PUNCT
admet-529	3	36	polarity	polarity	NOUN
admet-529	3	37	,	,	PUNCT
admet-529	3	38	and	and	CCONJ
admet-529	3	39	3d	3d	NUM
admet-529	3	40	concepts	concept	NOUN
admet-529	3	41	such	such	ADJ
admet-529	3	42	as	as	ADP
admet-529	3	43	conformational	conformational	ADJ
admet-529	3	44	states	state	NOUN
admet-529	3	45	,	,	PUNCT
admet-529	3	46	exposed	expose	VERB
admet-529	3	47	polarity	polarity	NOUN
admet-529	3	48	and	and	CCONJ
admet-529	3	49	intramolecular	intramolecular	ADJ
admet-529	3	50	hydrogen	hydrogen	NOUN
admet-529	3	51	bonds	bond	NOUN
admet-529	3	52	(	(	PUNCT
admet-529	3	53	imhb	imhb	NOUN
admet-529	3	54	)	)	PUNCT
admet-529	3	55	,	,	PUNCT
admet-529	3	56	are	be	AUX
admet-529	3	57	discussed	discuss	VERB
admet-529	3	58	along	along	ADP
admet-529	3	59	with	with	ADP
admet-529	3	60	recently	recently	ADV
admet-529	3	61	developed	develop	VERB
admet-529	3	62	methods	method	NOUN
admet-529	3	63	for	for	ADP
admet-529	3	64	incorporating	incorporate	VERB
admet-529	3	65	these	these	DET
admet-529	3	66	concepts	concept	NOUN
admet-529	3	67	into	into	ADP
admet-529	3	68	drug	drug	NOUN
admet-529	3	69	design	design	NOUN
admet-529	3	70	strategies	strategy	NOUN
admet-529	3	71	.	.	PUNCT
admet-529	4	1	in	in	ADP
admet-529	4	2	addition	addition	NOUN
admet-529	4	3	,	,	PUNCT
admet-529	4	4	the	the	DET
admet-529	4	5	drug	drug	NOUN
admet-529	4	6	design	design	NOUN
admet-529	4	7	process	process	NOUN
admet-529	4	8	is	be	AUX
admet-529	4	9	described	describe	VERB
admet-529	4	10	with	with	ADP
admet-529	4	11	examples	example	NOUN
admet-529	4	12	and	and	CCONJ
admet-529	4	13	practices	practice	NOUN
admet-529	4	14	used	use	VERB
admet-529	4	15	at	at	ADP
admet-529	4	16	pfizer	pfizer	NOUN
admet-529	4	17	,	,	PUNCT
admet-529	4	18	as	as	ADV
admet-529	4	19	well	well	ADV
admet-529	4	20	as	as	ADP
admet-529	4	21	experimental	experimental	ADJ
admet-529	4	22	and	and	CCONJ
admet-529	4	23	computed	computed	ADJ
admet-529	4	24	parameters	parameter	NOUN
admet-529	4	25	used	use	VERB
admet-529	4	26	for	for	ADP
admet-529	4	27	parallel	parallel	ADJ
admet-529	4	28	optimization	optimization	NOUN
admet-529	4	29	of	of	ADP
admet-529	4	30	properties	property	NOUN
admet-529	4	31	leading	lead	VERB
admet-529	4	32	to	to	ADP
admet-529	4	33	drug	drug	NOUN
admet-529	4	34	candidate	candidate	NOUN
admet-529	4	35	nominations	nomination	NOUN
admet-529	4	36	.	.	PUNCT
admet-529	5	1	keywords	keyword	NOUN
admet-529	5	2	elogd	elogd	ADJ
admet-529	5	3	,	,	PUNCT
admet-529	5	4	epsa	epsa	NOUN
admet-529	5	5	;	;	PUNCT
admet-529	5	6	lipophilicity	lipophilicity	NOUN
admet-529	5	7	,	,	PUNCT
admet-529	5	8	exposed	expose	VERB
admet-529	5	9	polarity	polarity	NOUN
admet-529	5	10	introduction	introduction	NOUN
admet-529	5	11	an	an	DET
admet-529	5	12	active	active	ADJ
admet-529	5	13	molecule	molecule	NOUN
admet-529	5	14	with	with	ADP
admet-529	5	15	favorable	favorable	ADJ
admet-529	5	16	pharmacokinetic	pharmacokinetic	ADJ
admet-529	5	17	/	/	SYM
admet-529	5	18	pharmacodynamic	pharmacodynamic	ADJ
admet-529	5	19	(	(	PUNCT
admet-529	5	20	pk	pk	NOUN
admet-529	5	21	/	/	SYM
admet-529	5	22	pd	pd	NOUN
admet-529	5	23	)	)	PUNCT
admet-529	5	24	properties	property	NOUN
admet-529	5	25	is	be	AUX
admet-529	5	26	the	the	DET
admet-529	5	27	goal	goal	NOUN
admet-529	5	28	of	of	ADP
admet-529	5	29	drug	drug	NOUN
admet-529	5	30	design	design	NOUN
admet-529	5	31	.	.	PUNCT
admet-529	6	1	this	this	PRON
admet-529	6	2	means	mean	VERB
admet-529	6	3	a	a	DET
admet-529	6	4	biologically	biologically	ADV
admet-529	6	5	active	active	ADJ
admet-529	6	6	molecule	molecule	NOUN
admet-529	6	7	can	can	AUX
admet-529	6	8	be	be	AUX
admet-529	6	9	developed	develop	VERB
admet-529	6	10	into	into	ADP
admet-529	6	11	a	a	DET
admet-529	6	12	drug	drug	NOUN
admet-529	6	13	only	only	ADV
admet-529	6	14	if	if	SCONJ
admet-529	6	15	it	it	PRON
admet-529	6	16	fits	fit	VERB
admet-529	6	17	strict	strict	ADJ
admet-529	6	18	pharmacological	pharmacological	NOUN
admet-529	6	19	profile	profile	NOUN
admet-529	6	20	requirements	requirement	NOUN
admet-529	6	21	.	.	PUNCT
admet-529	7	1	tablets	tablet	NOUN
admet-529	7	2	are	be	AUX
admet-529	7	3	the	the	DET
admet-529	7	4	preferred	preferred	ADJ
admet-529	7	5	form	form	NOUN
admet-529	7	6	of	of	ADP
admet-529	7	7	administration	administration	NOUN
admet-529	7	8	due	due	ADP
admet-529	7	9	to	to	ADP
admet-529	7	10	convenience	convenience	NOUN
admet-529	7	11	,	,	PUNCT
admet-529	7	12	patient	patient	ADJ
admet-529	7	13	compliance	compliance	NOUN
admet-529	7	14	and	and	CCONJ
admet-529	7	15	ease	ease	NOUN
admet-529	7	16	of	of	ADP
admet-529	7	17	manufacturing	manufacturing	NOUN
admet-529	7	18	.	.	PUNCT
admet-529	8	1	therefore	therefore	ADV
admet-529	8	2	most	most	ADJ
admet-529	8	3	drug	drug	NOUN
admet-529	8	4	design	design	NOUN
admet-529	8	5	projects	project	NOUN
admet-529	8	6	are	be	AUX
admet-529	8	7	focused	focus	VERB
admet-529	8	8	on	on	ADP
admet-529	8	9	creating	create	VERB
admet-529	8	10	drugs	drug	NOUN
admet-529	8	11	suitable	suitable	ADJ
admet-529	8	12	for	for	ADP
admet-529	8	13	oral	oral	ADJ
admet-529	8	14	dosage	dosage	NOUN
admet-529	8	15	.	.	PUNCT
admet-529	9	1	in	in	ADP
admet-529	9	2	order	order	NOUN
admet-529	9	3	to	to	PART
admet-529	9	4	be	be	AUX
admet-529	9	5	absorbed	absorb	VERB
admet-529	9	6	in	in	ADP
admet-529	9	7	the	the	DET
admet-529	9	8	gastrointestinal	gastrointestinal	ADJ
admet-529	9	9	(	(	PUNCT
admet-529	9	10	gi	gi	INTJ
admet-529	9	11	)	)	PUNCT
admet-529	9	12	tract	tract	NOUN
admet-529	9	13	,	,	PUNCT
admet-529	9	14	a	a	DET
admet-529	9	15	solid	solid	ADJ
admet-529	9	16	formulation	formulation	NOUN
admet-529	9	17	must	must	AUX
admet-529	9	18	be	be	AUX
admet-529	9	19	ingested	ingest	VERB
admet-529	9	20	,	,	PUNCT
admet-529	9	21	solubilized	solubilize	VERB
admet-529	9	22	.	.	PUNCT
admet-529	10	1	only	only	ADV
admet-529	10	2	then	then	ADV
admet-529	10	3	can	can	AUX
admet-529	10	4	the	the	DET
admet-529	10	5	solvated	solvate	VERB
admet-529	10	6	drug	drug	NOUN
admet-529	10	7	be	be	AUX
admet-529	10	8	absorbed	absorb	VERB
admet-529	10	9	into	into	ADP
admet-529	10	10	the	the	DET
admet-529	10	11	blood	blood	NOUN
admet-529	10	12	stream	stream	NOUN
admet-529	10	13	.	.	PUNCT
admet-529	11	1	here	here	ADV
admet-529	11	2	drug	drug	NOUN
admet-529	11	3	distribution	distribution	NOUN
admet-529	11	4	,	,	PUNCT
admet-529	11	5	metabolism	metabolism	NOUN
admet-529	11	6	and	and	CCONJ
admet-529	11	7	excretion	excretion	NOUN
admet-529	11	8	affect	affect	VERB
admet-529	11	9	its	its	PRON
admet-529	11	10	clearance	clearance	NOUN
admet-529	11	11	,	,	PUNCT
admet-529	11	12	defining	define	VERB
admet-529	11	13	the	the	DET
admet-529	11	14	pharmacokinetic	pharmacokinetic	ADJ
admet-529	11	15	parameters	parameter	NOUN
admet-529	11	16	,	,	PUNCT
admet-529	11	17	half	half	ADJ
admet-529	11	18	-	-	PUNCT
admet-529	11	19	life	life	NOUN
admet-529	11	20	and	and	CCONJ
admet-529	11	21	therapeutic	therapeutic	ADJ
admet-529	11	22	index	index	NOUN
admet-529	11	23	(	(	PUNCT
admet-529	11	24	ti	ti	NOUN
admet-529	11	25	)	)	PUNCT
admet-529	11	26	.	.	PUNCT
admet-529	12	1	balancing	balance	VERB
admet-529	12	2	absorption	absorption	NOUN
admet-529	12	3	,	,	PUNCT
admet-529	12	4	distribution	distribution	NOUN
admet-529	12	5	,	,	PUNCT
admet-529	12	6	metabolism	metabolism	NOUN
admet-529	12	7	,	,	PUNCT
admet-529	12	8	excretion	excretion	NOUN
admet-529	12	9	and	and	CCONJ
admet-529	12	10	toxicity	toxicity	NOUN
admet-529	12	11	(	(	PUNCT
admet-529	12	12	admet	admet	NOUN
admet-529	12	13	)	)	PUNCT
admet-529	12	14	properties	property	NOUN
admet-529	12	15	is	be	AUX
admet-529	12	16	a	a	DET
admet-529	12	17	major	major	ADJ
admet-529	12	18	challenge	challenge	NOUN
admet-529	12	19	in	in	ADP
admet-529	12	20	drug	drug	NOUN
admet-529	12	21	discovery	discovery	NOUN
admet-529	12	22	and	and	CCONJ
admet-529	12	23	development	development	NOUN
admet-529	12	24	.	.	PUNCT
admet-529	13	1	failure	failure	NOUN
admet-529	13	2	to	to	PART
admet-529	13	3	achieve	achieve	VERB
admet-529	13	4	the	the	DET
admet-529	13	5	right	right	ADJ
admet-529	13	6	admet	admet	NOUN
admet-529	13	7	balance	balance	NOUN
admet-529	13	8	was	be	AUX
admet-529	13	9	cited	cite	VERB
admet-529	13	10	in	in	ADP
admet-529	13	11	1997	1997	NUM
admet-529	13	12	as	as	ADP
admet-529	13	13	the	the	DET
admet-529	13	14	reason	reason	NOUN
admet-529	13	15	for	for	ADP
admet-529	13	16	the	the	DET
admet-529	13	17	attrition	attrition	NOUN
admet-529	13	18	of	of	ADP
admet-529	13	19	40	40	NUM
admet-529	13	20	%	%	NOUN
admet-529	13	21	of	of	ADP
admet-529	13	22	drug	drug	NOUN
admet-529	13	23	candidates	candidate	NOUN
admet-529	13	24	during	during	ADP
admet-529	13	25	development	development	NOUN
admet-529	13	26	[	[	X
admet-529	13	27	1	1	NUM
admet-529	13	28	]	]	PUNCT
admet-529	13	29	.	.	PUNCT
admet-529	14	1	here	here	ADV
admet-529	14	2	we	we	PRON
admet-529	14	3	present	present	VERB
admet-529	14	4	and	and	CCONJ
admet-529	14	5	discuss	discuss	VERB
admet-529	14	6	recent	recent	ADJ
admet-529	14	7	advances	advance	NOUN
admet-529	14	8	and	and	CCONJ
admet-529	14	9	approaches	approach	NOUN
admet-529	14	10	,	,	PUNCT
admet-529	14	11	mostly	mostly	ADV
admet-529	14	12	developed	develop	VERB
admet-529	14	13	at	at	ADP
admet-529	14	14	pfizer	pfizer	NOUN
admet-529	14	15	,	,	PUNCT
admet-529	14	16	using	use	VERB
admet-529	14	17	chromatographically	chromatographically	ADV
admet-529	14	18	determined	determine	VERB
admet-529	14	19	physicochemical	physicochemical	ADJ
admet-529	14	20	properties	property	NOUN
admet-529	14	21	for	for	ADP
admet-529	14	22	the	the	DET
admet-529	14	23	optimization	optimization	NOUN
admet-529	14	24	of	of	ADP
admet-529	14	25	admet	admet	PROPN
admet-529	14	26	properties	property	NOUN
admet-529	14	27	.	.	PUNCT
admet-529	15	1	lipophilicity	lipophilicity	NOUN
admet-529	15	2	lipophilicity	lipophilicity	NOUN
admet-529	15	3	(	(	PUNCT
admet-529	15	4	as	as	SCONJ
admet-529	15	5	defined	define	VERB
admet-529	15	6	by	by	ADP
admet-529	15	7	iupac	iupac	PROPN
admet-529	15	8	)	)	PUNCT
admet-529	15	9	represents	represent	VERB
admet-529	15	10	the	the	DET
admet-529	15	11	affinity	affinity	NOUN
admet-529	15	12	of	of	ADP
admet-529	15	13	a	a	DET
admet-529	15	14	molecule	molecule	NOUN
admet-529	15	15	or	or	CCONJ
admet-529	15	16	a	a	DET
admet-529	15	17	moiety	moiety	NOUN
admet-529	15	18	for	for	ADP
admet-529	15	19	a	a	DET
admet-529	15	20	lipophilic	lipophilic	ADJ
admet-529	15	21	environment	environment	NOUN
admet-529	15	22	.	.	PUNCT
admet-529	16	1	it	it	PRON
admet-529	16	2	is	be	AUX
admet-529	16	3	commonly	commonly	ADV
admet-529	16	4	measured	measure	VERB
admet-529	16	5	by	by	ADP
admet-529	16	6	its	its	PRON
admet-529	16	7	distribution	distribution	NOUN
admet-529	16	8	behavior	behavior	NOUN
admet-529	16	9	in	in	ADP
admet-529	16	10	a	a	DET
admet-529	16	11	biphasic	biphasic	ADJ
admet-529	16	12	system	system	NOUN
admet-529	16	13	,	,	PUNCT
admet-529	16	14	either	either	CCONJ
admet-529	16	15	liquid	liquid	NOUN
admet-529	16	16	-	-	PUNCT
admet-529	16	17	liquid	liquid	ADJ
admet-529	16	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-529	16	19	mailto:gilles.h.goetz@pfizer.com	mailto:gilles.h.goetz@pfizer.com	X
admet-529	16	20	g.h	g.h	PROPN
admet-529	16	21	.	.	PROPN
admet-529	16	22	goetz	goetz	PROPN
admet-529	16	23	and	and	CCONJ
admet-529	16	24	m.	m.	NOUN
admet-529	16	25	shalaeva	shalaeva	PROPN
admet-529	16	26	admet	admet	PROPN
admet-529	16	27	&	&	CCONJ
admet-529	16	28	dmpk	dmpk	PROPN
admet-529	16	29	6(2	6(2	NUM
admet-529	16	30	)	)	PUNCT
admet-529	16	31	(	(	PUNCT
admet-529	16	32	2018	2018	NUM
admet-529	16	33	)	)	PUNCT
admet-529	16	34	85	85	NUM
admet-529	16	35	-	-	SYM
admet-529	16	36	104	104	NUM
admet-529	16	37	86	86	NUM
admet-529	16	38	(	(	PUNCT
admet-529	16	39	partition	partition	NOUN
admet-529	16	40	coefficient	coefficient	NOUN
admet-529	16	41	between	between	ADP
admet-529	16	42	1	1	NUM
admet-529	16	43	-	-	PUNCT
admet-529	16	44	octanol	octanol	NOUN
admet-529	16	45	and	and	CCONJ
admet-529	16	46	water	water	NOUN
admet-529	16	47	)	)	PUNCT
admet-529	16	48	or	or	CCONJ
admet-529	16	49	solid	solid	ADJ
admet-529	16	50	-	-	PUNCT
admet-529	16	51	liquid	liquid	ADJ
admet-529	16	52	(	(	PUNCT
admet-529	16	53	retention	retention	NOUN
admet-529	16	54	on	on	ADP
admet-529	16	55	reversed	reverse	VERB
admet-529	16	56	phase	phase	NOUN
admet-529	16	57	high	high	ADJ
admet-529	16	58	performance	performance	NOUN
admet-529	16	59	liquid	liquid	NOUN
admet-529	16	60	chromatography	chromatography	NOUN
admet-529	16	61	(	(	PUNCT
admet-529	16	62	rp	rp	NOUN
admet-529	16	63	hplc	hplc	PROPN
admet-529	16	64	)	)	PUNCT
admet-529	16	65	)	)	PUNCT
admet-529	17	1	[	[	X
admet-529	17	2	2	2	NUM
admet-529	17	3	]	]	PUNCT
admet-529	17	4	:	:	PUNCT
admet-529	17	5	lipophilicity	lipophilicity	NOUN
admet-529	17	6	may	may	AUX
admet-529	17	7	be	be	AUX
admet-529	17	8	expressed	express	VERB
admet-529	17	9	as	as	ADP
admet-529	17	10	log	log	NOUN
admet-529	17	11	p	p	NOUN
admet-529	17	12	for	for	ADP
admet-529	17	13	neutral	neutral	ADJ
admet-529	17	14	molecules	molecule	NOUN
admet-529	17	15	and	and	CCONJ
admet-529	17	16	log	log	VERB
admet-529	17	17	d	d	NOUN
admet-529	17	18	for	for	ADP
admet-529	17	19	ionized	ionized	ADJ
admet-529	17	20	molecules	molecule	NOUN
admet-529	17	21	at	at	ADP
admet-529	17	22	a	a	DET
admet-529	17	23	particular	particular	ADJ
admet-529	17	24	ph	ph	NOUN
admet-529	17	25	(	(	PUNCT
admet-529	17	26	log	log	NOUN
admet-529	17	27	dph	dph	PROPN
admet-529	17	28	)	)	PUNCT
admet-529	17	29	,	,	PUNCT
admet-529	17	30	where	where	SCONJ
admet-529	17	31	permeation	permeation	NOUN
admet-529	17	32	p	p	NOUN
admet-529	17	33	and	and	CCONJ
admet-529	17	34	distribution	distribution	NOUN
admet-529	17	35	d	d	NOUN
admet-529	17	36	are	be	AUX
admet-529	17	37	defined	define	VERB
admet-529	17	38	by	by	ADP
admet-529	17	39	the	the	DET
admet-529	17	40	neutral	neutral	ADJ
admet-529	17	41	and	and	CCONJ
admet-529	17	42	ionized	ionized	ADJ
admet-529	17	43	species	specie	NOUN
admet-529	17	44	concentration	concentration	NOUN
admet-529	17	45	ratios	ratio	NOUN
admet-529	17	46	:	:	PUNCT
admet-529	17	47			ADJ
admet-529	17	48			ADP
admet-529	17	49			ADJ
admet-529	17	50			NOUN
admet-529	17	51	octanol	octanol	NOUN
admet-529	17	52	water	water	NOUN
admet-529	17	53	neutral	neutral	ADJ
admet-529	17	54	neutral	neutral	ADJ
admet-529	17	55	p	p	X
admet-529	17	56			PROPN
admet-529	17	57			ADJ
admet-529	17	58			ADP
admet-529	17	59			ADJ
admet-529	17	60			NOUN
admet-529	17	61	octanol	octanol	NOUN
admet-529	17	62	water	water	NOUN
admet-529	17	63	ionized	ionize	VERB
admet-529	17	64	+	+	CCONJ
admet-529	17	65	neutral	neutral	ADJ
admet-529	17	66	ionized	ionized	ADJ
admet-529	17	67	+	+	CCONJ
admet-529	17	68	neutral	neutral	ADJ
admet-529	17	69	d	d	X
admet-529	17	70			PROPN
admet-529	17	71	.	.	PUNCT
admet-529	18	1	successful	successful	ADJ
admet-529	18	2	drug	drug	NOUN
admet-529	18	3	designs	design	NOUN
admet-529	18	4	require	require	VERB
admet-529	18	5	careful	careful	ADJ
admet-529	18	6	balancing	balancing	NOUN
admet-529	18	7	of	of	ADP
admet-529	18	8	in	in	ADP
admet-529	18	9	vivo	vivo	NOUN
admet-529	18	10	and	and	CCONJ
admet-529	18	11	in	in	ADP
admet-529	18	12	vitro	vitro	X
admet-529	18	13	properties	property	NOUN
admet-529	18	14	.	.	PUNCT
admet-529	19	1	lipophilicity	lipophilicity	NOUN
admet-529	19	2	is	be	AUX
admet-529	19	3	a	a	DET
admet-529	19	4	descriptor	descriptor	NOUN
admet-529	19	5	intrinsic	intrinsic	ADJ
admet-529	19	6	to	to	ADP
admet-529	19	7	many	many	ADJ
admet-529	19	8	of	of	ADP
admet-529	19	9	these	these	DET
admet-529	19	10	properties	property	NOUN
admet-529	19	11	.	.	PUNCT
admet-529	20	1	computational	computational	ADJ
admet-529	20	2	models	model	NOUN
admet-529	20	3	of	of	ADP
admet-529	20	4	admet	admet	PROPN
admet-529	20	5	properties	property	NOUN
admet-529	20	6	generally	generally	ADV
admet-529	20	7	include	include	VERB
admet-529	20	8	log	log	NOUN
admet-529	20	9	p	p	NOUN
admet-529	20	10	as	as	ADP
admet-529	20	11	a	a	DET
admet-529	20	12	significant	significant	ADJ
admet-529	20	13	descriptor	descriptor	NOUN
admet-529	20	14	of	of	ADP
admet-529	20	15	the	the	DET
admet-529	20	16	modelled	model	VERB
admet-529	20	17	parameter	parameter	NOUN
admet-529	20	18	.	.	PUNCT
admet-529	21	1	an	an	DET
admet-529	21	2	extensive	extensive	ADJ
admet-529	21	3	analysis	analysis	NOUN
admet-529	21	4	of	of	ADP
admet-529	21	5	the	the	DET
admet-529	21	6	literature	literature	NOUN
admet-529	21	7	linking	link	VERB
admet-529	21	8	admet	admet	PROPN
admet-529	21	9	and	and	CCONJ
admet-529	21	10	lipophilicity	lipophilicity	NOUN
admet-529	21	11	in	in	ADP
admet-529	21	12	drug	drug	NOUN
admet-529	21	13	discovery	discovery	NOUN
admet-529	21	14	was	be	AUX
admet-529	21	15	published	publish	VERB
admet-529	21	16	by	by	ADP
admet-529	21	17	waring	ware	VERB
admet-529	21	18	[	[	X
admet-529	21	19	3	3	NUM
admet-529	21	20	]	]	PUNCT
admet-529	21	21	.	.	PUNCT
admet-529	22	1	it	it	PRON
admet-529	22	2	details	detail	VERB
admet-529	22	3	important	important	ADJ
admet-529	22	4	,	,	PUNCT
admet-529	22	5	but	but	CCONJ
admet-529	22	6	obscure	obscure	ADJ
admet-529	22	7	aspects	aspect	NOUN
admet-529	22	8	of	of	ADP
admet-529	22	9	the	the	DET
admet-529	22	10	log	log	NOUN
admet-529	22	11	d	d	NOUN
admet-529	22	12	parameter	parameter	NOUN
admet-529	22	13	.	.	PUNCT
admet-529	23	1	for	for	ADP
admet-529	23	2	example	example	NOUN
admet-529	23	3	,	,	PUNCT
admet-529	23	4	many	many	ADJ
admet-529	23	5	studies	study	NOUN
admet-529	23	6	rely	rely	VERB
admet-529	23	7	on	on	ADP
admet-529	23	8	compilations	compilation	NOUN
admet-529	23	9	of	of	ADP
admet-529	23	10	log	log	NOUN
admet-529	23	11	p	p	NOUN
admet-529	23	12	/	/	SYM
admet-529	23	13	log	log	NOUN
admet-529	23	14	d	d	NOUN
admet-529	23	15	values	value	NOUN
admet-529	23	16	from	from	ADP
admet-529	23	17	a	a	DET
admet-529	23	18	variety	variety	NOUN
admet-529	23	19	of	of	ADP
admet-529	23	20	sources	source	NOUN
admet-529	23	21	with	with	ADP
admet-529	23	22	poorly	poorly	ADV
admet-529	23	23	described	describe	VERB
admet-529	23	24	experimental	experimental	ADJ
admet-529	23	25	details	detail	NOUN
admet-529	23	26	.	.	PUNCT
admet-529	24	1	these	these	DET
admet-529	24	2	non	non	ADJ
admet-529	24	3	-	-	ADJ
admet-529	24	4	homogeneous	homogeneous	ADJ
admet-529	24	5	datasets	dataset	NOUN
admet-529	24	6	lead	lead	VERB
admet-529	24	7	to	to	ADP
admet-529	24	8	discrepancies	discrepancy	NOUN
admet-529	24	9	in	in	ADP
admet-529	24	10	analyses	analysis	NOUN
admet-529	24	11	.	.	PUNCT
admet-529	25	1	there	there	PRON
admet-529	25	2	is	be	VERB
admet-529	25	3	also	also	ADV
admet-529	25	4	confusion	confusion	NOUN
admet-529	25	5	between	between	ADP
admet-529	25	6	log	log	NOUN
admet-529	25	7	p	p	NOUN
admet-529	25	8	and	and	CCONJ
admet-529	25	9	log	log	VERB
admet-529	25	10	d	d	NOUN
admet-529	25	11	;	;	PUNCT
admet-529	25	12	terms	term	NOUN
admet-529	25	13	often	often	ADV
admet-529	25	14	used	use	VERB
admet-529	25	15	interchangeably	interchangeably	ADV
admet-529	25	16	.	.	PUNCT
admet-529	26	1	for	for	ADP
admet-529	26	2	drug	drug	NOUN
admet-529	26	3	compounds	compound	NOUN
admet-529	26	4	ionized	ionize	VERB
admet-529	26	5	at	at	ADP
admet-529	26	6	physiological	physiological	ADJ
admet-529	26	7	ph	ph	NOUN
admet-529	26	8	,	,	PUNCT
admet-529	26	9	log	log	PROPN
admet-529	26	10	dph	dph	PROPN
admet-529	26	11	is	be	AUX
admet-529	26	12	more	more	ADV
admet-529	26	13	relevant	relevant	ADJ
admet-529	26	14	than	than	ADP
admet-529	26	15	log	log	VERB
admet-529	26	16	p	p	PRON
admet-529	26	17	,	,	PUNCT
admet-529	26	18	however	however	ADV
admet-529	26	19	,	,	PUNCT
admet-529	26	20	it	it	PRON
admet-529	26	21	deviates	deviate	VERB
admet-529	26	22	because	because	SCONJ
admet-529	26	23	of	of	ADP
admet-529	26	24	its	its	PRON
admet-529	26	25	dependence	dependence	NOUN
admet-529	26	26	on	on	ADP
admet-529	26	27	pka	pka	PROPN
admet-529	26	28	.	.	PUNCT
admet-529	27	1	this	this	PRON
admet-529	27	2	is	be	AUX
admet-529	27	3	especially	especially	ADV
admet-529	27	4	flagrant	flagrant	ADJ
admet-529	27	5	,	,	PUNCT
admet-529	27	6	in	in	ADP
admet-529	27	7	case	case	NOUN
admet-529	27	8	of	of	ADP
admet-529	27	9	predicted	predict	VERB
admet-529	27	10	log	log	NOUN
admet-529	27	11	dph	dph	PROPN
admet-529	27	12	,	,	PUNCT
admet-529	27	13	due	due	ADP
admet-529	27	14	to	to	ADP
admet-529	27	15	unreliable	unreliable	ADJ
admet-529	27	16	pka	pka	NOUN
admet-529	27	17	predictions	prediction	NOUN
admet-529	27	18	.	.	PUNCT
admet-529	28	1	the	the	DET
admet-529	28	2	widely	widely	ADV
admet-529	28	3	cited	cite	VERB
admet-529	28	4	publication	publication	NOUN
admet-529	28	5	by	by	ADP
admet-529	28	6	mannhold	mannhold	PROPN
admet-529	28	7	et	et	PROPN
admet-529	28	8	al	al	PROPN
admet-529	28	9	.	.	PUNCT
admet-529	29	1	[	[	X
admet-529	29	2	4	4	X
admet-529	29	3	]	]	PUNCT
admet-529	29	4	compares	compare	VERB
admet-529	29	5	several	several	ADJ
admet-529	29	6	computed	computed	ADJ
admet-529	29	7	log	log	NOUN
admet-529	29	8	p	p	NOUN
admet-529	29	9	models	model	NOUN
admet-529	29	10	to	to	ADP
admet-529	29	11	over	over	ADP
admet-529	29	12	96,000	96,000	NUM
admet-529	29	13	measured	measure	VERB
admet-529	29	14	values	value	NOUN
admet-529	29	15	.	.	PUNCT
admet-529	30	1	unfortunately	unfortunately	ADV
admet-529	30	2	,	,	PUNCT
admet-529	30	3	actual	actual	ADJ
admet-529	30	4	experimental	experimental	ADJ
admet-529	30	5	details	detail	NOUN
admet-529	30	6	were	be	AUX
admet-529	30	7	not	not	PART
admet-529	30	8	provided	provide	VERB
admet-529	30	9	.	.	PUNCT
admet-529	31	1	many	many	ADJ
admet-529	31	2	research	research	NOUN
admet-529	31	3	organizations	organization	NOUN
admet-529	31	4	have	have	AUX
admet-529	31	5	developed	develop	VERB
admet-529	31	6	their	their	PRON
admet-529	31	7	own	own	ADJ
admet-529	31	8	methods	method	NOUN
admet-529	31	9	for	for	ADP
admet-529	31	10	lipophilicity	lipophilicity	NOUN
admet-529	31	11	measurements	measurement	NOUN
admet-529	31	12	.	.	PUNCT
admet-529	32	1	they	they	PRON
admet-529	32	2	use	use	VERB
admet-529	32	3	their	their	PRON
admet-529	32	4	particular	particular	ADJ
admet-529	32	5	values	value	NOUN
admet-529	32	6	for	for	ADP
admet-529	32	7	drug	drug	NOUN
admet-529	32	8	design	design	NOUN
admet-529	32	9	and	and	CCONJ
admet-529	32	10	optimization	optimization	NOUN
admet-529	32	11	,	,	PUNCT
admet-529	32	12	i.e.	i.e.	X
admet-529	32	13	chromatographic	chromatographic	ADJ
admet-529	32	14	hydrophobicity	hydrophobicity	NOUN
admet-529	32	15	index	index	NOUN
admet-529	32	16	(	(	PUNCT
admet-529	32	17	chi	chi	NOUN
admet-529	32	18	)	)	PUNCT
admet-529	32	19	at	at	ADP
admet-529	32	20	glaxosmithkline	glaxosmithkline	PROPN
admet-529	33	1	[	[	X
admet-529	33	2	5	5	NUM
admet-529	33	3	]	]	PUNCT
admet-529	33	4	,	,	PUNCT
admet-529	33	5	and	and	CCONJ
admet-529	33	6	elog	elog	NOUN
admet-529	33	7	d	d	NOUN
admet-529	33	8	at	at	ADP
admet-529	33	9	pfizer	pfizer	NOUN
admet-529	34	1	[	[	X
admet-529	34	2	6	6	NUM
admet-529	34	3	]	]	PUNCT
admet-529	34	4	.	.	PUNCT
admet-529	35	1	early	early	ADJ
admet-529	35	2	stage	stage	NOUN
admet-529	35	3	drug	drug	NOUN
admet-529	35	4	design	design	NOUN
admet-529	35	5	strives	strive	VERB
admet-529	35	6	to	to	PART
admet-529	35	7	create	create	VERB
admet-529	35	8	the	the	DET
admet-529	35	9	most	most	ADV
admet-529	35	10	active	active	ADJ
admet-529	35	11	molecule	molecule	NOUN
admet-529	35	12	for	for	ADP
admet-529	35	13	a	a	DET
admet-529	35	14	particular	particular	ADJ
admet-529	35	15	therapeutic	therapeutic	ADJ
admet-529	35	16	target	target	NOUN
admet-529	35	17	.	.	PUNCT
admet-529	36	1	the	the	DET
admet-529	36	2	ultimate	ultimate	ADJ
admet-529	36	3	goal	goal	NOUN
admet-529	36	4	is	be	AUX
admet-529	36	5	the	the	DET
admet-529	36	6	discovery	discovery	NOUN
admet-529	36	7	of	of	ADP
admet-529	36	8	a	a	DET
admet-529	36	9	molecule	molecule	NOUN
admet-529	36	10	possessing	possess	VERB
admet-529	36	11	“	"	PUNCT
admet-529	36	12	drug	drug	NOUN
admet-529	36	13	-	-	PUNCT
admet-529	36	14	like	like	ADJ
admet-529	36	15	”	"	PUNCT
admet-529	36	16	properties	property	NOUN
admet-529	36	17	.	.	PUNCT
admet-529	37	1	the	the	DET
admet-529	37	2	reliance	reliance	NOUN
admet-529	37	3	on	on	ADP
admet-529	37	4	lipophilicity	lipophilicity	NOUN
admet-529	37	5	to	to	PART
admet-529	37	6	understand	understand	VERB
admet-529	37	7	molecules	molecule	NOUN
admet-529	37	8	'	'	PART
admet-529	37	9	drug	drug	NOUN
admet-529	37	10	-	-	PUNCT
admet-529	37	11	like	like	ADJ
admet-529	37	12	properties	property	NOUN
admet-529	37	13	was	be	AUX
admet-529	37	14	defined	define	VERB
admet-529	37	15	in	in	ADP
admet-529	37	16	1997	1997	NUM
admet-529	37	17	lipinski	lipinski	PROPN
admet-529	37	18	's	's	PART
admet-529	37	19	“	"	PUNCT
admet-529	37	20	rule	rule	NOUN
admet-529	37	21	of	of	ADP
admet-529	37	22	five	five	NUM
admet-529	37	23	”	"	PUNCT
admet-529	37	24	(	(	PUNCT
admet-529	37	25	ro5	ro5	PROPN
admet-529	37	26	)	)	PUNCT
admet-529	37	27	[	[	X
admet-529	37	28	7	7	NUM
admet-529	37	29	]	]	PUNCT
admet-529	37	30	.	.	PUNCT
admet-529	38	1	now	now	ADV
admet-529	38	2	it	it	PRON
admet-529	38	3	is	be	AUX
admet-529	38	4	ingrained	ingrain	VERB
admet-529	38	5	into	into	ADP
admet-529	38	6	drug	drug	NOUN
admet-529	38	7	design	design	NOUN
admet-529	38	8	that	that	PRON
admet-529	38	9	oral	oral	ADJ
admet-529	38	10	drugs	drug	NOUN
admet-529	38	11	require	require	VERB
admet-529	38	12	a	a	DET
admet-529	38	13	clogp	clogp	NOUN
admet-529	38	14	<	<	X
admet-529	38	15	5	5	NUM
admet-529	38	16	.	.	PUNCT
admet-529	38	17	rules	rule	NOUN
admet-529	38	18	,	,	PUNCT
admet-529	38	19	depending	depend	VERB
admet-529	38	20	mostly	mostly	ADV
admet-529	38	21	on	on	ADP
admet-529	38	22	log	log	PROPN
admet-529	38	23	d	d	PROPN
admet-529	38	24	,	,	PUNCT
admet-529	38	25	help	help	VERB
admet-529	38	26	guide	guide	VERB
admet-529	38	27	designs	design	NOUN
admet-529	38	28	towards	towards	ADP
admet-529	38	29	optimal	optimal	ADJ
admet-529	38	30	drug	drug	NOUN
admet-529	38	31	-	-	PUNCT
admet-529	38	32	like	like	ADJ
admet-529	38	33	chemistry	chemistry	NOUN
admet-529	38	34	space	space	NOUN
admet-529	38	35	.	.	PUNCT
admet-529	39	1	log	log	PROPN
admet-529	39	2	d	d	NOUN
admet-529	39	3	is	be	AUX
admet-529	39	4	used	use	VERB
admet-529	39	5	to	to	PART
admet-529	39	6	calculate	calculate	VERB
admet-529	39	7	ligand	ligand	NOUN
admet-529	39	8	efficiency	efficiency	NOUN
admet-529	39	9	(	(	PUNCT
admet-529	39	10	le	le	X
admet-529	39	11	)	)	PUNCT
admet-529	40	1	[	[	X
admet-529	40	2	8,9	8,9	NUM
admet-529	40	3	]	]	PUNCT
admet-529	40	4	,	,	PUNCT
admet-529	40	5	metabolic	metabolic	NOUN
admet-529	40	6	efficiency	efficiency	NOUN
admet-529	40	7	(	(	PUNCT
admet-529	40	8	mete	mete	NOUN
admet-529	40	9	)	)	PUNCT
admet-529	41	1	[	[	X
admet-529	41	2	3,10,11	3,10,11	NUM
admet-529	41	3	]	]	PUNCT
admet-529	41	4	,	,	PUNCT
admet-529	41	5	central	central	ADJ
admet-529	41	6	nervous	nervous	ADJ
admet-529	41	7	system	system	NOUN
admet-529	41	8	multiparameter	multiparameter	NOUN
admet-529	41	9	optimization	optimization	NOUN
admet-529	41	10	(	(	PUNCT
admet-529	41	11	cns	cns	PROPN
admet-529	41	12	mpo	mpo	PROPN
admet-529	41	13	)	)	PUNCT
admet-529	42	1	[	[	X
admet-529	42	2	12,13	12,13	NUM
admet-529	42	3	]	]	PUNCT
admet-529	42	4	,	,	PUNCT
admet-529	42	5	and	and	CCONJ
admet-529	42	6	toxicity	toxicity	NOUN
admet-529	42	7	scores	score	NOUN
admet-529	43	1	[	[	X
admet-529	43	2	14	14	NUM
admet-529	43	3	-	-	SYM
admet-529	43	4	16	16	NUM
admet-529	43	5	]	]	PUNCT
admet-529	43	6	.	.	PUNCT
admet-529	44	1	recent	recent	ADJ
admet-529	44	2	developments	development	NOUN
admet-529	44	3	are	be	AUX
admet-529	44	4	reviewed	review	VERB
admet-529	44	5	in	in	ADP
admet-529	44	6	the	the	DET
admet-529	44	7	application	application	NOUN
admet-529	44	8	of	of	ADP
admet-529	44	9	log	log	NOUN
admet-529	44	10	d	d	PROPN
admet-529	44	11	for	for	ADP
admet-529	44	12	balancing	balance	VERB
admet-529	44	13	potency	potency	NOUN
admet-529	44	14	and	and	CCONJ
admet-529	44	15	adme	adme	NOUN
admet-529	44	16	properties	property	NOUN
admet-529	44	17	.	.	PUNCT
admet-529	45	1	lipophilicity	lipophilicity	NOUN
admet-529	45	2	and	and	CCONJ
admet-529	45	3	ligand	ligand	ADJ
admet-529	45	4	efficiency	efficiency	NOUN
admet-529	45	5	the	the	DET
admet-529	45	6	review	review	NOUN
admet-529	45	7	by	by	ADP
admet-529	45	8	hopkins	hopkins	PROPN
admet-529	45	9	et	et	PROPN
admet-529	45	10	al	al	PROPN
admet-529	45	11	.	.	PUNCT
admet-529	46	1	[	[	X
admet-529	46	2	17	17	NUM
admet-529	46	3	]	]	PUNCT
admet-529	46	4	concluded	conclude	VERB
admet-529	46	5	that	that	SCONJ
admet-529	46	6	recently	recently	ADV
admet-529	46	7	marketed	market	VERB
admet-529	46	8	oral	oral	ADJ
admet-529	46	9	drugs	drug	NOUN
admet-529	46	10	“	"	PUNCT
admet-529	46	11	frequently	frequently	ADV
admet-529	46	12	have	have	VERB
admet-529	46	13	highly	highly	ADV
admet-529	46	14	optimized	optimize	VERB
admet-529	46	15	ligand	ligand	NOUN
admet-529	46	16	efficiency	efficiency	NOUN
admet-529	46	17	values	value	NOUN
admet-529	46	18	for	for	ADP
admet-529	46	19	their	their	PRON
admet-529	46	20	targets	target	NOUN
admet-529	46	21	”	"	PUNCT
admet-529	46	22	.	.	PUNCT
admet-529	47	1	early	early	ADJ
admet-529	47	2	stage	stage	NOUN
admet-529	47	3	design	design	NOUN
admet-529	47	4	efforts	effort	NOUN
admet-529	47	5	often	often	ADV
admet-529	47	6	lead	lead	VERB
admet-529	47	7	to	to	ADP
admet-529	47	8	series	series	NOUN
admet-529	47	9	of	of	ADP
admet-529	47	10	hundreds	hundred	NOUN
admet-529	47	11	of	of	ADP
admet-529	47	12	newly	newly	ADV
admet-529	47	13	synthesized	synthesize	VERB
admet-529	47	14	compounds	compound	NOUN
admet-529	47	15	.	.	PUNCT
admet-529	48	1	these	these	DET
admet-529	48	2	structures	structure	NOUN
admet-529	48	3	need	need	VERB
admet-529	48	4	to	to	PART
admet-529	48	5	be	be	AUX
admet-529	48	6	rapidly	rapidly	ADV
admet-529	48	7	evaluated	evaluate	VERB
admet-529	48	8	for	for	SCONJ
admet-529	48	9	projects	project	NOUN
admet-529	48	10	to	to	PART
admet-529	48	11	proceed	proceed	VERB
admet-529	48	12	.	.	PUNCT
admet-529	49	1	promising	promise	VERB
admet-529	49	2	leads	lead	NOUN
admet-529	49	3	may	may	AUX
admet-529	49	4	be	be	AUX
admet-529	49	5	prioritized	prioritize	VERB
admet-529	49	6	using	use	VERB
admet-529	49	7	lipophilic	lipophilic	ADJ
admet-529	49	8	ligand	ligand	NOUN
admet-529	49	9	efficiency	efficiency	NOUN
admet-529	49	10	(	(	PUNCT
admet-529	49	11	lle	lle	PROPN
admet-529	49	12	)	)	PUNCT
admet-529	50	1	[	[	X
admet-529	50	2	9	9	NUM
admet-529	50	3	]	]	PUNCT
admet-529	50	4	or	or	CCONJ
admet-529	50	5	lipe	lipe	NOUN
admet-529	51	1	[	[	X
admet-529	51	2	10	10	NUM
admet-529	51	3	]	]	X
admet-529	51	4	:	:	PUNCT
admet-529	51	5	lle	lle	PROPN
admet-529	51	6	(	(	PUNCT
admet-529	51	7	or	or	CCONJ
admet-529	51	8	lipe	lipe	NOUN
admet-529	51	9	)	)	PUNCT
admet-529	52	1	=	=	SYM
admet-529	52	2	pic50	pic50	NOUN
admet-529	52	3	–	–	PUNCT
admet-529	52	4	clogp	clogp	ADJ
admet-529	52	5	.	.	PUNCT
admet-529	53	1	the	the	DET
admet-529	53	2	lle	lle	PROPN
admet-529	53	3	/	/	SYM
admet-529	53	4	lipe	lipe	PROPN
admet-529	53	5	concept	concept	NOUN
admet-529	53	6	has	have	AUX
admet-529	53	7	been	be	AUX
admet-529	53	8	developed	develop	VERB
admet-529	53	9	following	follow	VERB
admet-529	53	10	the	the	DET
admet-529	53	11	introduction	introduction	NOUN
admet-529	53	12	of	of	ADP
admet-529	53	13	ligand	ligand	ADJ
admet-529	53	14	efficiency	efficiency	NOUN
admet-529	53	15	(	(	PUNCT
admet-529	53	16	le	le	X
admet-529	53	17	)	)	PUNCT
admet-529	54	1	[	[	X
admet-529	54	2	8	8	NUM
admet-529	54	3	]	]	PUNCT
admet-529	54	4	.	.	PUNCT
admet-529	55	1	the	the	DET
admet-529	55	2	le	le	PROPN
admet-529	55	3	parameter	parameter	PROPN
admet-529	55	4	allows	allow	VERB
admet-529	55	5	direct	direct	ADJ
admet-529	55	6	comparison	comparison	NOUN
admet-529	55	7	of	of	ADP
admet-529	55	8	molecules	molecule	NOUN
admet-529	55	9	through	through	ADP
admet-529	55	10	their	their	PRON
admet-529	55	11	target	target	NOUN
admet-529	55	12	binding	bind	VERB
admet-529	55	13	energy	energy	NOUN
admet-529	55	14	.	.	PUNCT
admet-529	56	1	le	le	PROPN
admet-529	56	2	can	can	AUX
admet-529	56	3	be	be	AUX
admet-529	56	4	expressed	express	VERB
admet-529	56	5	admet	admet	PROPN
admet-529	56	6	&	&	CCONJ
admet-529	56	7	dmpk	dmpk	PROPN
admet-529	56	8	6(2	6(2	NUM
admet-529	56	9	)	)	PUNCT
admet-529	56	10	(	(	PUNCT
admet-529	56	11	2018	2018	NUM
admet-529	56	12	)	)	PUNCT
admet-529	56	13	85	85	NUM
admet-529	56	14	-	-	SYM
admet-529	56	15	104	104	NUM
admet-529	56	16	leveraging	leverage	VERB
admet-529	56	17	chromatography	chromatography	NOUN
admet-529	56	18	physchem	physchem	NOUN
admet-529	56	19	properties	property	NOUN
admet-529	56	20	in	in	ADP
admet-529	56	21	drug	drug	NOUN
admet-529	56	22	design	design	NOUN
admet-529	56	23	doi	doi	NOUN
admet-529	56	24	:	:	PUNCT
admet-529	56	25	10.5599	10.5599	NUM
admet-529	56	26	/	/	SYM
admet-529	56	27	admet.529	admet.529	NOUN
admet-529	56	28	87	87	NUM
admet-529	56	29	by	by	ADP
admet-529	56	30	the	the	DET
admet-529	56	31	following	following	ADJ
admet-529	56	32	simplified	simplified	ADJ
admet-529	56	33	equation	equation	NOUN
admet-529	56	34	in	in	ADP
admet-529	56	35	which	which	PRON
admet-529	56	36	n	n	ADV
admet-529	56	37	is	be	AUX
admet-529	56	38	the	the	DET
admet-529	56	39	number	number	NOUN
admet-529	56	40	of	of	ADP
admet-529	56	41	non	non	ADJ
admet-529	56	42	-	-	ADJ
admet-529	56	43	hydrogen	hydrogen	ADJ
admet-529	56	44	atoms	atom	NOUN
admet-529	56	45	:	:	PUNCT
admet-529	56	46	le	le	X
admet-529	56	47	=	=	SYM
admet-529	56	48	1.37(-log	1.37(-log	NUM
admet-529	56	49	ic50)/n	ic50)/n	NOUN
admet-529	56	50	.	.	PUNCT
admet-529	57	1	project	project	NOUN
admet-529	57	2	progress	progress	NOUN
admet-529	57	3	may	may	AUX
admet-529	57	4	be	be	AUX
admet-529	57	5	tracked	track	VERB
admet-529	57	6	using	use	VERB
admet-529	57	7	both	both	CCONJ
admet-529	57	8	le	le	X
admet-529	57	9	and	and	CCONJ
admet-529	57	10	lipe	lipe	PROPN
admet-529	57	11	;	;	PUNCT
admet-529	57	12	lipe	lipe	PROPN
admet-529	57	13	is	be	AUX
admet-529	57	14	expected	expect	VERB
admet-529	57	15	to	to	PART
admet-529	57	16	reach	reach	VERB
admet-529	57	17	values	value	NOUN
admet-529	57	18	of	of	ADP
admet-529	57	19	6	6	NUM
admet-529	57	20	or	or	CCONJ
admet-529	57	21	7	7	NUM
admet-529	57	22	for	for	ADP
admet-529	57	23	a	a	DET
admet-529	57	24	potential	potential	ADJ
admet-529	57	25	drug	drug	NOUN
admet-529	57	26	candidate	candidate	NOUN
admet-529	57	27	to	to	PART
admet-529	57	28	be	be	AUX
admet-529	57	29	chosen	choose	VERB
admet-529	57	30	for	for	ADP
admet-529	57	31	further	further	ADJ
admet-529	57	32	development	development	NOUN
admet-529	58	1	[	[	X
admet-529	58	2	18	18	NUM
admet-529	58	3	-	-	SYM
admet-529	58	4	20	20	NUM
admet-529	58	5	]	]	PUNCT
admet-529	58	6	.	.	PUNCT
admet-529	59	1	target	target	VERB
admet-529	59	2	binding	bind	VERB
admet-529	59	3	increases	increase	NOUN
admet-529	59	4	with	with	ADP
admet-529	59	5	the	the	DET
admet-529	59	6	addition	addition	NOUN
admet-529	59	7	of	of	ADP
admet-529	59	8	a	a	DET
admet-529	59	9	lipophilic	lipophilic	ADJ
admet-529	59	10	fragment	fragment	NOUN
admet-529	59	11	,	,	PUNCT
admet-529	59	12	at	at	ADP
admet-529	59	13	the	the	DET
admet-529	59	14	expense	expense	NOUN
admet-529	59	15	of	of	ADP
admet-529	59	16	potential	potential	NOUN
admet-529	59	17	for	for	ADP
admet-529	59	18	offtarget	offtarget	NOUN
admet-529	59	19	binding	bind	VERB
admet-529	59	20	and	and	CCONJ
admet-529	59	21	decreased	decrease	VERB
admet-529	59	22	solubility	solubility	NOUN
admet-529	59	23	.	.	PUNCT
admet-529	60	1	an	an	DET
admet-529	60	2	efficient	efficient	ADJ
admet-529	60	3	drug	drug	NOUN
admet-529	60	4	design	design	NOUN
admet-529	60	5	requires	require	VERB
admet-529	60	6	potency	potency	NOUN
admet-529	60	7	to	to	PART
admet-529	60	8	be	be	AUX
admet-529	60	9	achieved	achieve	VERB
admet-529	60	10	with	with	ADP
admet-529	60	11	a	a	DET
admet-529	60	12	minimal	minimal	ADJ
admet-529	60	13	increase	increase	NOUN
admet-529	60	14	in	in	ADP
admet-529	60	15	mw	mw	NOUN
admet-529	60	16	or	or	CCONJ
admet-529	60	17	lipophilicity	lipophilicity	NOUN
admet-529	60	18	[	[	X
admet-529	60	19	21	21	NUM
admet-529	60	20	-	-	SYM
admet-529	60	21	24	24	NUM
admet-529	60	22	]	]	PUNCT
admet-529	60	23	.	.	PUNCT
admet-529	61	1	lipophilicity	lipophilicity	NOUN
admet-529	61	2	and	and	CCONJ
admet-529	61	3	oral	oral	ADJ
admet-529	61	4	absorption	absorption	NOUN
admet-529	61	5	oral	oral	ADJ
admet-529	61	6	administration	administration	NOUN
admet-529	61	7	,	,	PUNCT
admet-529	61	8	the	the	DET
admet-529	61	9	most	most	ADV
admet-529	61	10	desirable	desirable	ADJ
admet-529	61	11	route	route	NOUN
admet-529	61	12	of	of	ADP
admet-529	61	13	medicine	medicine	NOUN
admet-529	61	14	delivery	delivery	NOUN
admet-529	61	15	,	,	PUNCT
admet-529	61	16	requires	require	VERB
admet-529	61	17	a	a	DET
admet-529	61	18	drug	drug	NOUN
admet-529	61	19	to	to	PART
admet-529	61	20	be	be	AUX
admet-529	61	21	absorbed	absorb	VERB
admet-529	61	22	while	while	SCONJ
admet-529	61	23	in	in	ADP
admet-529	61	24	the	the	DET
admet-529	61	25	gi	gi	NOUN
admet-529	61	26	tract	tract	NOUN
admet-529	61	27	,	,	PUNCT
admet-529	61	28	with	with	ADP
admet-529	61	29	cell	cell	NOUN
admet-529	61	30	membrane	membrane	NOUN
admet-529	61	31	permeation	permeation	NOUN
admet-529	61	32	being	be	AUX
admet-529	61	33	the	the	DET
admet-529	61	34	major	major	ADJ
admet-529	61	35	determinant	determinant	NOUN
admet-529	61	36	of	of	ADP
admet-529	61	37	absorption	absorption	NOUN
admet-529	61	38	.	.	PUNCT
admet-529	62	1	there	there	PRON
admet-529	62	2	are	be	VERB
admet-529	62	3	several	several	ADJ
admet-529	62	4	processes	process	NOUN
admet-529	62	5	involved	involve	VERB
admet-529	62	6	in	in	ADP
admet-529	62	7	crossing	cross	VERB
admet-529	62	8	the	the	DET
admet-529	62	9	intestinal	intestinal	ADJ
admet-529	62	10	mucosa	mucosa	NOUN
admet-529	62	11	,	,	PUNCT
admet-529	62	12	including	include	VERB
admet-529	62	13	active	active	ADJ
admet-529	62	14	transport	transport	NOUN
admet-529	62	15	[	[	X
admet-529	62	16	15	15	NUM
admet-529	62	17	]	]	PUNCT
admet-529	62	18	,	,	PUNCT
admet-529	62	19	paracellular	paracellular	ADJ
admet-529	62	20	transport	transport	NOUN
admet-529	62	21	,	,	PUNCT
admet-529	62	22	and	and	CCONJ
admet-529	62	23	drug	drug	NOUN
admet-529	62	24	efflux	efflux	NOUN
admet-529	62	25	.	.	PUNCT
admet-529	63	1	passive	passive	ADJ
admet-529	63	2	membrane	membrane	NOUN
admet-529	63	3	diffusion	diffusion	NOUN
admet-529	63	4	is	be	AUX
admet-529	63	5	considered	consider	VERB
admet-529	63	6	to	to	PART
admet-529	63	7	be	be	AUX
admet-529	63	8	the	the	DET
admet-529	63	9	major	major	ADJ
admet-529	63	10	contributing	contributing	NOUN
admet-529	63	11	process	process	NOUN
admet-529	63	12	[	[	X
admet-529	63	13	25	25	NUM
admet-529	63	14	]	]	PUNCT
admet-529	63	15	.	.	PUNCT
admet-529	64	1	recent	recent	ADJ
admet-529	64	2	analyses	analysis	NOUN
admet-529	64	3	continue	continue	VERB
admet-529	64	4	to	to	PART
admet-529	64	5	demonstrate	demonstrate	VERB
admet-529	64	6	the	the	DET
admet-529	64	7	significance	significance	NOUN
admet-529	64	8	of	of	ADP
admet-529	64	9	the	the	DET
admet-529	64	10	non	non	ADJ
admet-529	64	11	-	-	ADJ
admet-529	64	12	specific	specific	ADJ
admet-529	64	13	permeation	permeation	NOUN
admet-529	64	14	mechanisms	mechanism	NOUN
admet-529	64	15	governed	govern	VERB
admet-529	64	16	by	by	ADP
admet-529	64	17	molecular	molecular	ADJ
admet-529	64	18	properties	property	NOUN
admet-529	64	19	(	(	PUNCT
admet-529	64	20	namely	namely	ADV
admet-529	64	21	molecular	molecular	ADJ
admet-529	64	22	size	size	NOUN
admet-529	64	23	and	and	CCONJ
admet-529	64	24	polarity	polarity	NOUN
admet-529	64	25	)	)	PUNCT
admet-529	65	1	[	[	X
admet-529	65	2	16	16	NUM
admet-529	65	3	]	]	PUNCT
admet-529	65	4	.	.	PUNCT
admet-529	66	1	the	the	DET
admet-529	66	2	favorable	favorable	ADJ
admet-529	66	3	property	property	NOUN
admet-529	66	4	space	space	NOUN
admet-529	66	5	for	for	ADP
admet-529	66	6	an	an	DET
admet-529	66	7	orally	orally	ADV
admet-529	66	8	administered	administer	VERB
admet-529	66	9	drugs	drug	NOUN
admet-529	66	10	is	be	AUX
admet-529	66	11	defined	define	VERB
admet-529	66	12	by	by	ADP
admet-529	66	13	the	the	DET
admet-529	66	14	afore	afore	NOUN
admet-529	66	15	mentioned	mention	VERB
admet-529	66	16	ro5	ro5	ADJ
admet-529	66	17	[	[	X
admet-529	66	18	26,27	26,27	NUM
admet-529	66	19	]	]	PUNCT
admet-529	66	20	.	.	PUNCT
admet-529	67	1	in	in	ADP
admet-529	67	2	order	order	NOUN
admet-529	67	3	to	to	PART
admet-529	67	4	achieve	achieve	VERB
admet-529	67	5	absorption	absorption	NOUN
admet-529	67	6	,	,	PUNCT
admet-529	67	7	an	an	DET
admet-529	67	8	oral	oral	ADJ
admet-529	67	9	drug	drug	NOUN
admet-529	67	10	needs	need	VERB
admet-529	67	11	to	to	PART
admet-529	67	12	have	have	VERB
admet-529	67	13	a	a	DET
admet-529	67	14	clogp	clogp	NOUN
admet-529	67	15	<	<	X
admet-529	67	16	5	5	NUM
admet-529	67	17	;	;	PUNCT
admet-529	67	18	mw	mw	X
admet-529	67	19	<	<	X
admet-529	67	20	500	500	NUM
admet-529	67	21	;	;	PUNCT
admet-529	67	22	hydrogen	hydrogen	NOUN
admet-529	67	23	bond	bond	NOUN
admet-529	67	24	donor	donor	NOUN
admet-529	67	25	(	(	PUNCT
admet-529	67	26	hbd	hbd	NOUN
admet-529	67	27	)	)	PUNCT
admet-529	67	28	count	count	NOUN
admet-529	67	29	(	(	PUNCT
admet-529	67	30	nh+oh	nh+oh	NOUN
admet-529	67	31	)	)	PUNCT
admet-529	67	32	<	<	X
admet-529	67	33	5	5	NUM
admet-529	67	34	;	;	PUNCT
admet-529	67	35	and	and	CCONJ
admet-529	67	36	a	a	DET
admet-529	67	37	hydrogen	hydrogen	NOUN
admet-529	67	38	bond	bond	NOUN
admet-529	67	39	acceptor	acceptor	NOUN
admet-529	67	40	(	(	PUNCT
admet-529	67	41	hba	hba	NOUN
admet-529	67	42	)	)	PUNCT
admet-529	67	43	count	count	NOUN
admet-529	67	44	(	(	PUNCT
admet-529	67	45	n+o	n+o	NUM
admet-529	67	46	)	)	PUNCT
admet-529	67	47	<	<	X
admet-529	67	48	10	10	NUM
admet-529	67	49	.	.	PUNCT
admet-529	68	1	more	more	ADJ
admet-529	68	2	specific	specific	ADJ
admet-529	68	3	rules	rule	NOUN
admet-529	68	4	were	be	AUX
admet-529	68	5	developed	develop	VERB
admet-529	68	6	for	for	ADP
admet-529	68	7	central	central	ADJ
admet-529	68	8	nervous	nervous	ADJ
admet-529	68	9	system	system	NOUN
admet-529	68	10	(	(	PUNCT
admet-529	68	11	cns	cns	NOUN
admet-529	68	12	)	)	PUNCT
admet-529	68	13	projects	project	NOUN
admet-529	68	14	,	,	PUNCT
admet-529	68	15	where	where	SCONJ
admet-529	68	16	crossing	cross	VERB
admet-529	68	17	the	the	DET
admet-529	68	18	blood	blood	NOUN
admet-529	68	19	-	-	PUNCT
admet-529	68	20	brain	brain	NOUN
admet-529	68	21	barrier	barrier	NOUN
admet-529	68	22	is	be	AUX
admet-529	68	23	challenging	challenge	VERB
admet-529	68	24	due	due	ADJ
admet-529	68	25	to	to	ADP
admet-529	68	26	tighter	tight	ADJ
admet-529	68	27	junctions	junction	NOUN
admet-529	68	28	and	and	CCONJ
admet-529	68	29	higher	high	ADJ
admet-529	68	30	efflux	efflux	NOUN
admet-529	68	31	.	.	PUNCT
admet-529	69	1	the	the	DET
admet-529	69	2	cns	cns	PROPN
admet-529	69	3	mpo	mpo	PROPN
admet-529	69	4	score	score	NOUN
admet-529	69	5	introduced	introduce	VERB
admet-529	69	6	by	by	ADP
admet-529	69	7	wager	wager	NOUN
admet-529	69	8	et	et	PROPN
admet-529	69	9	al	al	PROPN
admet-529	69	10	.	.	PUNCT
admet-529	70	1	[	[	X
admet-529	70	2	12	12	NUM
admet-529	70	3	]	]	PUNCT
admet-529	70	4	was	be	AUX
admet-529	70	5	derived	derive	VERB
admet-529	70	6	by	by	ADP
admet-529	70	7	analysis	analysis	NOUN
admet-529	70	8	of	of	ADP
admet-529	70	9	drugs	drug	NOUN
admet-529	70	10	and	and	CCONJ
admet-529	70	11	candidates	candidate	NOUN
admet-529	70	12	with	with	ADP
admet-529	70	13	regard	regard	NOUN
admet-529	70	14	to	to	ADP
admet-529	70	15	their	their	PRON
admet-529	70	16	ability	ability	NOUN
admet-529	70	17	to	to	PART
admet-529	70	18	cross	cross	VERB
admet-529	70	19	the	the	DET
admet-529	70	20	blood	blood	NOUN
admet-529	70	21	-	-	PUNCT
admet-529	70	22	brain	brain	NOUN
admet-529	70	23	barrier	barrier	NOUN
admet-529	70	24	.	.	PUNCT
admet-529	71	1	the	the	DET
admet-529	71	2	cns	cns	PROPN
admet-529	71	3	mpo	mpo	PROPN
admet-529	71	4	includes	include	VERB
admet-529	71	5	ionization	ionization	NOUN
admet-529	71	6	constant	constant	ADJ
admet-529	71	7	(	(	PUNCT
admet-529	71	8	pka	pka	NOUN
admet-529	71	9	)	)	PUNCT
admet-529	71	10	,	,	PUNCT
admet-529	71	11	log	log	VERB
admet-529	71	12	p	p	NOUN
admet-529	71	13	,	,	PUNCT
admet-529	71	14	and	and	CCONJ
admet-529	71	15	log	log	VERB
admet-529	71	16	d7.4	d7.4	PROPN
admet-529	71	17	.	.	PUNCT
admet-529	72	1	this	this	PRON
admet-529	72	2	emphasizes	emphasize	VERB
admet-529	72	3	the	the	DET
admet-529	72	4	importance	importance	NOUN
admet-529	72	5	of	of	ADP
admet-529	72	6	ionization	ionization	NOUN
admet-529	72	7	and	and	CCONJ
admet-529	72	8	lipophilicity	lipophilicity	NOUN
admet-529	72	9	adjusted	adjust	VERB
admet-529	72	10	for	for	ADP
admet-529	72	11	ionization	ionization	NOUN
admet-529	72	12	[	[	X
admet-529	72	13	13,23,28,29	13,23,28,29	NUM
admet-529	72	14	]	]	PUNCT
admet-529	72	15	.	.	PUNCT
admet-529	73	1	recently	recently	ADV
admet-529	73	2	z.	z.	PROPN
admet-529	73	3	ranković	ranković	PROPN
admet-529	73	4	further	far	ADV
admet-529	73	5	refined	refine	VERB
admet-529	73	6	the	the	DET
admet-529	73	7	cns	cns	NOUN
admet-529	73	8	desirability	desirability	NOUN
admet-529	73	9	criteria	criterion	NOUN
admet-529	73	10	in	in	ADP
admet-529	73	11	cns	cns	PROPN
admet-529	73	12	mpov.2	mpov.2	PROPN
admet-529	73	13	[	[	X
admet-529	73	14	30	30	NUM
admet-529	73	15	]	]	PUNCT
admet-529	73	16	.	.	PUNCT
admet-529	74	1	lipophilicity	lipophilicity	NOUN
admet-529	74	2	measurements	measurement	NOUN
admet-529	74	3	also	also	ADV
admet-529	74	4	help	help	VERB
admet-529	74	5	to	to	PART
admet-529	74	6	estimate	estimate	VERB
admet-529	74	7	solubility	solubility	NOUN
admet-529	74	8	in	in	ADP
admet-529	74	9	discovery	discovery	NOUN
admet-529	74	10	settings	setting	NOUN
admet-529	74	11	[	[	X
admet-529	74	12	31	31	NUM
admet-529	74	13	]	]	PUNCT
admet-529	74	14	;	;	PUNCT
admet-529	74	15	solubility	solubility	NOUN
admet-529	74	16	decreases	decrease	VERB
admet-529	74	17	with	with	ADP
admet-529	74	18	log	log	PROPN
admet-529	74	19	p	p	PROPN
admet-529	74	20	>	>	X
admet-529	74	21	3	3	X
admet-529	74	22	.	.	PUNCT
admet-529	74	23	current	current	ADJ
admet-529	74	24	trend	trend	NOUN
admet-529	74	25	towards	towards	ADP
admet-529	74	26	and	and	CCONJ
admet-529	74	27	beyond	beyond	ADP
admet-529	74	28	ro5	ro5	ADJ
admet-529	74	29	compounds	compound	NOUN
admet-529	74	30	recently	recently	ADV
admet-529	74	31	,	,	PUNCT
admet-529	74	32	the	the	DET
admet-529	74	33	introduction	introduction	NOUN
admet-529	74	34	of	of	ADP
admet-529	74	35	innovative	innovative	ADJ
admet-529	74	36	“	"	PUNCT
admet-529	74	37	flat	flat	ADJ
admet-529	74	38	”	"	PUNCT
admet-529	74	39	targets	target	NOUN
admet-529	74	40	and	and	CCONJ
admet-529	74	41	the	the	DET
admet-529	74	42	potential	potential	NOUN
admet-529	74	43	for	for	ADP
admet-529	74	44	higher	high	ADJ
admet-529	74	45	potency	potency	NOUN
admet-529	74	46	and	and	CCONJ
admet-529	74	47	selectivity	selectivity	NOUN
admet-529	74	48	provided	provide	VERB
admet-529	74	49	by	by	ADP
admet-529	74	50	larger	large	ADJ
admet-529	74	51	molecules	molecule	NOUN
admet-529	74	52	,	,	PUNCT
admet-529	74	53	has	have	AUX
admet-529	74	54	led	lead	VERB
admet-529	74	55	to	to	ADP
admet-529	74	56	a	a	DET
admet-529	74	57	renewed	renew	VERB
admet-529	74	58	interest	interest	NOUN
admet-529	74	59	in	in	ADP
admet-529	74	60	peptide	peptide	NOUN
admet-529	74	61	-	-	PUNCT
admet-529	74	62	based	base	VERB
admet-529	74	63	drugs	drug	NOUN
admet-529	74	64	.	.	PUNCT
admet-529	75	1	these	these	PRON
admet-529	75	2	fill	fill	VERB
admet-529	75	3	the	the	DET
admet-529	75	4	gap	gap	NOUN
admet-529	75	5	between	between	ADP
admet-529	75	6	small	small	ADJ
admet-529	75	7	molecules	molecule	NOUN
admet-529	75	8	and	and	CCONJ
admet-529	75	9	biotherapeutics	biotherapeutic	NOUN
admet-529	75	10	,	,	PUNCT
admet-529	75	11	as	as	SCONJ
admet-529	75	12	illustrated	illustrate	VERB
admet-529	75	13	in	in	ADP
admet-529	75	14	figure	figure	NOUN
admet-529	75	15	1	1	NUM
admet-529	76	1	[	[	X
admet-529	76	2	32,33	32,33	NUM
admet-529	76	3	]	]	PUNCT
admet-529	76	4	.	.	PUNCT
admet-529	77	1	the	the	DET
admet-529	77	2	exploration	exploration	NOUN
admet-529	77	3	of	of	ADP
admet-529	77	4	new	new	ADJ
admet-529	77	5	targets	target	NOUN
admet-529	77	6	required	require	VERB
admet-529	77	7	new	new	ADJ
admet-529	77	8	design	design	NOUN
admet-529	77	9	concepts	concept	NOUN
admet-529	77	10	including	include	VERB
admet-529	77	11	“	"	PUNCT
admet-529	77	12	an	an	DET
admet-529	77	13	update	update	NOUN
admet-529	77	14	”	"	PUNCT
admet-529	77	15	to	to	ADP
admet-529	77	16	ro5	ro5	PROPN
admet-529	77	17	.	.	PROPN
admet-529	77	18	bunnage	bunnage	NOUN
admet-529	77	19	et	et	PROPN
admet-529	77	20	al	al	PROPN
admet-529	77	21	.	.	PROPN
admet-529	77	22	defined	define	VERB
admet-529	77	23	"	"	PUNCT
admet-529	77	24	four	four	NUM
admet-529	77	25	pillars	pillar	NOUN
admet-529	77	26	of	of	ADP
admet-529	77	27	target	target	NOUN
admet-529	77	28	validation	validation	NOUN
admet-529	77	29	”	"	PUNCT
admet-529	77	30	,	,	PUNCT
admet-529	77	31	the	the	DET
admet-529	77	32	first	first	ADJ
admet-529	77	33	pillar	pillar	NOUN
admet-529	77	34	being	be	AUX
admet-529	77	35	“	"	PUNCT
admet-529	77	36	exposure	exposure	NOUN
admet-529	77	37	at	at	ADP
admet-529	77	38	the	the	DET
admet-529	77	39	site	site	NOUN
admet-529	77	40	of	of	ADP
admet-529	77	41	action	action	NOUN
admet-529	77	42	”	"	PUNCT
admet-529	77	43	,	,	PUNCT
admet-529	77	44	defined	define	VERB
admet-529	77	45	largely	largely	ADV
admet-529	77	46	by	by	ADP
admet-529	77	47	permeability	permeability	NOUN
admet-529	77	48	,	,	PUNCT
admet-529	77	49	where	where	SCONJ
admet-529	77	50	tactics	tactic	NOUN
admet-529	77	51	such	such	ADJ
admet-529	77	52	as	as	ADP
admet-529	77	53	increasing	increase	VERB
admet-529	77	54	lipophilicity	lipophilicity	NOUN
admet-529	77	55	could	could	AUX
admet-529	77	56	help	help	VERB
admet-529	77	57	improve	improve	VERB
admet-529	77	58	both	both	DET
admet-529	77	59	potency	potency	NOUN
admet-529	77	60	and	and	CCONJ
admet-529	77	61	permeability	permeability	NOUN
admet-529	78	1	[	[	X
admet-529	78	2	34	34	NUM
admet-529	78	3	]	]	PUNCT
admet-529	78	4	.	.	PUNCT
admet-529	79	1	failing	fail	VERB
admet-529	79	2	one	one	NUM
admet-529	79	3	or	or	CCONJ
admet-529	79	4	more	more	ADJ
admet-529	79	5	of	of	ADP
admet-529	79	6	the	the	DET
admet-529	79	7	ro5	ro5	NOUN
admet-529	79	8	may	may	AUX
admet-529	79	9	decrease	decrease	VERB
admet-529	79	10	oral	oral	ADJ
admet-529	79	11	bioavailability	bioavailability	NOUN
admet-529	79	12	,	,	PUNCT
admet-529	79	13	due	due	ADP
admet-529	79	14	to	to	ADP
admet-529	79	15	low	low	ADJ
admet-529	79	16	solubility	solubility	NOUN
admet-529	79	17	,	,	PUNCT
admet-529	79	18	and	and	CCONJ
admet-529	79	19	or	or	CCONJ
admet-529	79	20	poor	poor	ADJ
admet-529	79	21	membrane	membrane	NOUN
admet-529	79	22	permeability	permeability	NOUN
admet-529	79	23	,	,	PUNCT
admet-529	79	24	in	in	ADP
admet-529	79	25	addition	addition	NOUN
admet-529	79	26	to	to	ADP
admet-529	79	27	metabolic	metabolic	NOUN
admet-529	79	28	instability	instability	NOUN
admet-529	79	29	,	,	PUNCT
admet-529	79	30	synthetic	synthetic	ADJ
admet-529	79	31	complexity	complexity	NOUN
admet-529	79	32	and	and	CCONJ
admet-529	79	33	other	other	ADJ
admet-529	79	34	disadvantages	disadvantage	NOUN
admet-529	79	35	of	of	ADP
admet-529	79	36	large	large	ADJ
admet-529	79	37	drug	drug	NOUN
admet-529	79	38	molecules	molecule	NOUN
admet-529	79	39	.	.	PUNCT
admet-529	80	1	the	the	DET
admet-529	80	2	study	study	NOUN
admet-529	80	3	by	by	ADP
admet-529	80	4	guimarães	guimarães	PROPN
admet-529	80	5	et	et	PROPN
admet-529	80	6	al	al	PROPN
admet-529	80	7	.	.	PUNCT
admet-529	81	1	[	[	X
admet-529	81	2	35	35	NUM
admet-529	81	3	]	]	PUNCT
admet-529	81	4	highlighted	highlight	VERB
admet-529	81	5	the	the	DET
admet-529	81	6	importance	importance	NOUN
admet-529	81	7	of	of	ADP
admet-529	81	8	3	3	NUM
admet-529	81	9	-	-	PUNCT
admet-529	81	10	d	d	NOUN
admet-529	81	11	properties	property	NOUN
admet-529	81	12	for	for	ADP
admet-529	81	13	passive	passive	ADJ
admet-529	81	14	permeation	permeation	NOUN
admet-529	81	15	of	of	ADP
admet-529	81	16	beyond	beyond	ADP
admet-529	81	17	ro5	ro5	ADJ
admet-529	81	18	(	(	PUNCT
admet-529	81	19	bro5	bro5	NOUN
admet-529	81	20	)	)	PUNCT
admet-529	81	21	molecules	molecule	NOUN
admet-529	81	22	,	,	PUNCT
admet-529	81	23	where	where	SCONJ
admet-529	81	24	taking	take	VERB
admet-529	81	25	molecular	molecular	ADJ
admet-529	81	26	conformation	conformation	NOUN
admet-529	81	27	into	into	ADP
admet-529	81	28	account	account	NOUN
admet-529	81	29	,	,	PUNCT
admet-529	81	30	as	as	ADV
admet-529	81	31	well	well	ADV
admet-529	81	32	as	as	ADP
admet-529	81	33	size	size	NOUN
admet-529	81	34	and	and	CCONJ
admet-529	81	35	polarity	polarity	NOUN
admet-529	81	36	assessments	assessment	NOUN
admet-529	81	37	,	,	PUNCT
admet-529	81	38	are	be	AUX
admet-529	81	39	needed	need	VERB
admet-529	81	40	to	to	PART
admet-529	81	41	aid	aid	VERB
admet-529	81	42	design	design	NOUN
admet-529	81	43	in	in	ADP
admet-529	81	44	bro5	bro5	NOUN
admet-529	81	45	space	space	NOUN
admet-529	81	46	.	.	PUNCT
admet-529	82	1	g.h	g.h	PROPN
admet-529	82	2	.	.	PROPN
admet-529	83	1	goetz	goetz	PROPN
admet-529	83	2	and	and	CCONJ
admet-529	83	3	m.	m.	NOUN
admet-529	83	4	shalaeva	shalaeva	PROPN
admet-529	83	5	admet	admet	PROPN
admet-529	83	6	&	&	CCONJ
admet-529	83	7	dmpk	dmpk	PROPN
admet-529	83	8	6(2	6(2	NUM
admet-529	83	9	)	)	PUNCT
admet-529	83	10	(	(	PUNCT
admet-529	83	11	2018	2018	NUM
admet-529	83	12	)	)	PUNCT
admet-529	83	13	85	85	NUM
admet-529	83	14	-	-	SYM
admet-529	83	15	104	104	NUM
admet-529	83	16	88	88	NUM
admet-529	83	17	figure	figure	NOUN
admet-529	83	18	1	1	NUM
admet-529	83	19	.	.	PUNCT
admet-529	83	20	schematic	schematic	ADJ
admet-529	83	21	illustration	illustration	NOUN
admet-529	83	22	of	of	ADP
admet-529	83	23	the	the	DET
admet-529	83	24	molecular	molecular	ADJ
admet-529	83	25	weight	weight	NOUN
admet-529	83	26	(	(	PUNCT
admet-529	83	27	mw	mw	NOUN
admet-529	83	28	)	)	PUNCT
admet-529	83	29	gap	gap	NOUN
admet-529	83	30	between	between	ADP
admet-529	83	31	conventional	conventional	ADJ
admet-529	83	32	small	small	ADJ
admet-529	83	33	molecule	molecule	NOUN
admet-529	83	34	drugs	drug	NOUN
admet-529	83	35	(	(	PUNCT
admet-529	83	36	<	<	X
admet-529	83	37	500	500	NUM
admet-529	83	38	)	)	PUNCT
admet-529	83	39	and	and	CCONJ
admet-529	83	40	biologics	biologic	NOUN
admet-529	83	41	(	(	PUNCT
admet-529	83	42	>	>	NOUN
admet-529	83	43	5000	5000	NUM
admet-529	83	44	)	)	PUNCT
admet-529	83	45	.	.	PUNCT
admet-529	84	1	reprinted	reprint	VERB
admet-529	84	2	from	from	ADP
admet-529	84	3	[	[	X
admet-529	84	4	32	32	NUM
admet-529	84	5	]	]	X
admet-529	84	6	copyright	copyright	NOUN
admet-529	84	7	(	(	PUNCT
admet-529	84	8	2013	2013	NUM
admet-529	84	9	)	)	PUNCT
admet-529	84	10	,	,	PUNCT
admet-529	84	11	with	with	ADP
admet-529	84	12	permission	permission	NOUN
admet-529	84	13	from	from	ADP
admet-529	84	14	wiley	wiley	NOUN
admet-529	84	15	.	.	PUNCT
admet-529	85	1	the	the	DET
admet-529	85	2	ro5	ro5	ADJ
admet-529	85	3	defines	define	NOUN
admet-529	85	4	properties	property	NOUN
admet-529	85	5	of	of	ADP
admet-529	85	6	drug	drug	NOUN
admet-529	85	7	-	-	PUNCT
admet-529	85	8	like	like	ADJ
admet-529	85	9	molecules	molecule	NOUN
admet-529	85	10	,	,	PUNCT
admet-529	85	11	essentially	essentially	ADV
admet-529	85	12	,	,	PUNCT
admet-529	85	13	via	via	ADP
admet-529	85	14	molecular	molecular	ADJ
admet-529	85	15	size	size	NOUN
admet-529	85	16	and	and	CCONJ
admet-529	85	17	polarity	polarity	NOUN
admet-529	85	18	,	,	PUNCT
admet-529	85	19	where	where	SCONJ
admet-529	85	20	mw	mw	PROPN
admet-529	85	21	describes	describe	VERB
admet-529	85	22	the	the	DET
admet-529	85	23	size	size	NOUN
admet-529	85	24	,	,	PUNCT
admet-529	85	25	hbd	hbd	NOUN
admet-529	85	26	and	and	CCONJ
admet-529	85	27	hba	hba	NOUN
admet-529	85	28	counts	count	NOUN
admet-529	85	29	describe	describe	VERB
admet-529	85	30	polarity	polarity	NOUN
admet-529	85	31	and	and	CCONJ
admet-529	85	32	log	log	NOUN
admet-529	85	33	d	d	NOUN
admet-529	85	34	describes	describe	VERB
admet-529	85	35	both	both	PRON
admet-529	85	36	.	.	PUNCT
admet-529	86	1	notably	notably	ADV
admet-529	86	2	,	,	PUNCT
admet-529	86	3	mw	mw	NOUN
admet-529	86	4	and	and	CCONJ
admet-529	86	5	nh	nh	PROPN
admet-529	86	6	,	,	PUNCT
admet-529	86	7	oh	oh	INTJ
admet-529	86	8	,	,	PUNCT
admet-529	86	9	o	o	PROPN
admet-529	86	10	and	and	CCONJ
admet-529	86	11	n	n	PROPN
admet-529	86	12	are	be	AUX
admet-529	86	13	just	just	ADV
admet-529	86	14	simple	simple	ADJ
admet-529	86	15	counts	count	NOUN
admet-529	86	16	and	and	CCONJ
admet-529	86	17	only	only	ADV
admet-529	86	18	roughly	roughly	ADV
admet-529	86	19	describe	describe	VERB
admet-529	86	20	interactions	interaction	NOUN
admet-529	86	21	with	with	ADP
admet-529	86	22	the	the	DET
admet-529	86	23	environment	environment	NOUN
admet-529	86	24	,	,	PUNCT
admet-529	86	25	especially	especially	ADV
admet-529	86	26	for	for	ADP
admet-529	86	27	molecules	molecule	NOUN
admet-529	86	28	of	of	ADP
admet-529	86	29	any	any	DET
admet-529	86	30	complexity	complexity	NOUN
admet-529	86	31	.	.	PUNCT
admet-529	87	1	for	for	ADP
admet-529	87	2	example	example	NOUN
admet-529	87	3	,	,	PUNCT
admet-529	87	4	intramolecular	intramolecular	ADJ
admet-529	87	5	hydrogen	hydrogen	NOUN
admet-529	87	6	bonding	bonding	NOUN
admet-529	87	7	(	(	PUNCT
admet-529	87	8	imhb	imhb	NOUN
admet-529	87	9	)	)	PUNCT
admet-529	87	10	in	in	ADP
admet-529	87	11	large	large	ADJ
admet-529	87	12	,	,	PUNCT
admet-529	87	13	flexible	flexible	ADJ
admet-529	87	14	molecules	molecule	NOUN
admet-529	87	15	could	could	AUX
admet-529	87	16	lead	lead	VERB
admet-529	87	17	to	to	ADP
admet-529	87	18	shielding	shielding	NOUN
admet-529	87	19	of	of	ADP
admet-529	87	20	hbd	hbd	NOUN
admet-529	87	21	and	and	CCONJ
admet-529	87	22	hba	hba	PROPN
admet-529	87	23	and	and	CCONJ
admet-529	87	24	,	,	PUNCT
admet-529	87	25	consequently	consequently	ADV
admet-529	87	26	,	,	PUNCT
admet-529	87	27	to	to	ADP
admet-529	87	28	changes	change	NOUN
admet-529	87	29	in	in	ADP
admet-529	87	30	molecular	molecular	ADJ
admet-529	87	31	shape	shape	NOUN
admet-529	87	32	and	and	CCONJ
admet-529	87	33	size	size	NOUN
admet-529	87	34	,	,	PUNCT
admet-529	87	35	which	which	PRON
admet-529	87	36	are	be	AUX
admet-529	87	37	not	not	PART
admet-529	87	38	accounted	account	VERB
admet-529	87	39	for	for	ADP
admet-529	87	40	by	by	ADP
admet-529	87	41	mw	mw	NOUN
admet-529	87	42	or	or	CCONJ
admet-529	87	43	hbd	hbd	NOUN
admet-529	87	44	and	and	CCONJ
admet-529	87	45	hba	hba	NOUN
admet-529	87	46	counts	count	NOUN
admet-529	87	47	.	.	PUNCT
admet-529	88	1	these	these	DET
admet-529	88	2	simple	simple	ADJ
admet-529	88	3	counts	count	NOUN
admet-529	88	4	,	,	PUNCT
admet-529	88	5	including	include	VERB
admet-529	88	6	polar	polar	ADJ
admet-529	88	7	surface	surface	NOUN
admet-529	88	8	area	area	NOUN
admet-529	88	9	(	(	PUNCT
admet-529	88	10	psa	psa	NOUN
admet-529	88	11	)	)	PUNCT
admet-529	88	12	,	,	PUNCT
admet-529	88	13	are	be	AUX
admet-529	88	14	indifferent	indifferent	ADJ
admet-529	88	15	to	to	ADP
admet-529	88	16	changes	change	NOUN
admet-529	88	17	in	in	ADP
admet-529	88	18	molecular	molecular	ADJ
admet-529	88	19	shape	shape	NOUN
admet-529	88	20	and	and	CCONJ
admet-529	88	21	size	size	NOUN
admet-529	88	22	,	,	PUNCT
admet-529	88	23	the	the	DET
admet-529	88	24	major	major	ADJ
admet-529	88	25	determinants	determinant	NOUN
admet-529	88	26	of	of	ADP
admet-529	88	27	passive	passive	ADJ
admet-529	88	28	diffusion	diffusion	NOUN
admet-529	88	29	[	[	X
admet-529	88	30	35	35	NUM
admet-529	88	31	]	]	PUNCT
admet-529	88	32	.	.	PUNCT
admet-529	89	1	experimental	experimental	ADJ
admet-529	89	2	log	log	PROPN
admet-529	89	3	d	d	NOUN
admet-529	89	4	,	,	PUNCT
admet-529	89	5	on	on	ADP
admet-529	89	6	the	the	DET
admet-529	89	7	other	other	ADJ
admet-529	89	8	hand	hand	NOUN
admet-529	89	9	,	,	PUNCT
admet-529	89	10	accounts	account	VERB
admet-529	89	11	for	for	ADP
admet-529	89	12	molecular	molecular	ADJ
admet-529	89	13	size	size	NOUN
admet-529	89	14	and	and	CCONJ
admet-529	89	15	polarity	polarity	NOUN
admet-529	89	16	in	in	ADP
admet-529	89	17	solution	solution	NOUN
admet-529	89	18	and	and	CCONJ
admet-529	89	19	for	for	ADP
admet-529	89	20	3d	3d	NUM
admet-529	89	21	conformational	conformational	ADJ
admet-529	89	22	changes	change	NOUN
admet-529	89	23	adopted	adopt	VERB
admet-529	89	24	by	by	ADP
admet-529	89	25	the	the	DET
admet-529	89	26	molecule	molecule	NOUN
admet-529	89	27	.	.	PUNCT
admet-529	90	1	therefore	therefore	ADV
admet-529	90	2	,	,	PUNCT
admet-529	90	3	the	the	DET
admet-529	90	4	“	"	PUNCT
admet-529	90	5	extension	extension	NOUN
admet-529	90	6	”	"	PUNCT
admet-529	90	7	of	of	ADP
admet-529	90	8	the	the	DET
admet-529	90	9	ro5	ro5	NOUN
admet-529	90	10	to	to	ADP
admet-529	90	11	large	large	ADJ
admet-529	90	12	molecules	molecule	NOUN
admet-529	90	13	depends	depend	VERB
admet-529	90	14	even	even	ADV
admet-529	90	15	more	more	ADV
admet-529	90	16	on	on	ADP
admet-529	90	17	the	the	DET
admet-529	90	18	“	"	PUNCT
admet-529	90	19	effectiveness	effectiveness	NOUN
admet-529	90	20	”	"	PUNCT
admet-529	90	21	of	of	ADP
admet-529	90	22	the	the	DET
admet-529	90	23	log	log	NOUN
admet-529	90	24	d	d	NOUN
admet-529	90	25	parameter	parameter	NOUN
admet-529	90	26	.	.	PUNCT
admet-529	91	1	while	while	SCONJ
admet-529	91	2	the	the	DET
admet-529	91	3	accuracy	accuracy	NOUN
admet-529	91	4	of	of	ADP
admet-529	91	5	log	log	NOUN
admet-529	91	6	d	d	NOUN
admet-529	91	7	prediction	prediction	NOUN
admet-529	91	8	is	be	AUX
admet-529	91	9	important	important	ADJ
admet-529	91	10	for	for	ADP
admet-529	91	11	large	large	ADJ
admet-529	91	12	,	,	PUNCT
admet-529	91	13	flexible	flexible	ADJ
admet-529	91	14	molecules	molecule	NOUN
admet-529	91	15	,	,	PUNCT
admet-529	91	16	it	it	PRON
admet-529	91	17	is	be	AUX
admet-529	91	18	also	also	ADV
admet-529	91	19	much	much	ADV
admet-529	91	20	more	more	ADV
admet-529	91	21	difficult	difficult	ADJ
admet-529	91	22	to	to	PART
admet-529	91	23	predict	predict	VERB
admet-529	91	24	,	,	PUNCT
admet-529	91	25	as	as	SCONJ
admet-529	91	26	it	it	PRON
admet-529	91	27	deals	deal	VERB
admet-529	91	28	with	with	ADP
admet-529	91	29	the	the	DET
admet-529	91	30	assessment	assessment	NOUN
admet-529	91	31	of	of	ADP
admet-529	91	32	multiple	multiple	ADJ
admet-529	91	33	conformations	conformation	NOUN
admet-529	91	34	and	and	CCONJ
admet-529	91	35	their	their	PRON
admet-529	91	36	populations	population	NOUN
admet-529	91	37	.	.	PUNCT
admet-529	92	1	measured	measure	VERB
admet-529	92	2	log	log	NOUN
admet-529	92	3	d	d	NOUN
admet-529	92	4	values	value	NOUN
admet-529	92	5	are	be	AUX
admet-529	92	6	necessary	necessary	ADJ
admet-529	92	7	to	to	PART
admet-529	92	8	build	build	VERB
admet-529	92	9	and	and	CCONJ
admet-529	92	10	test	test	VERB
admet-529	92	11	such	such	ADJ
admet-529	92	12	computational	computational	ADJ
admet-529	92	13	models	model	NOUN
admet-529	92	14	for	for	ADP
admet-529	92	15	bro5	bro5	NOUN
admet-529	92	16	compounds	compound	NOUN
admet-529	92	17	.	.	PUNCT
admet-529	93	1	however	however	ADV
admet-529	93	2	,	,	PUNCT
admet-529	93	3	log	log	VERB
admet-529	93	4	d	d	NOUN
admet-529	93	5	values	value	NOUN
admet-529	93	6	>	>	X
admet-529	93	7	3	3	NUM
admet-529	93	8	are	be	AUX
admet-529	93	9	challenging	challenge	VERB
admet-529	93	10	to	to	PART
admet-529	93	11	obtain	obtain	VERB
admet-529	93	12	via	via	ADP
admet-529	93	13	conventional	conventional	ADJ
admet-529	93	14	shake	shake	NOUN
admet-529	93	15	-	-	PUNCT
admet-529	93	16	flask	flask	NOUN
admet-529	93	17	log	log	NOUN
admet-529	93	18	d	d	NOUN
admet-529	93	19	(	(	PUNCT
admet-529	93	20	sflog	sflog	PROPN
admet-529	93	21	d	d	PROPN
admet-529	93	22	)	)	PUNCT
admet-529	93	23	,	,	PUNCT
admet-529	93	24	due	due	ADP
admet-529	93	25	to	to	ADP
admet-529	93	26	limits	limit	NOUN
admet-529	93	27	in	in	ADP
admet-529	93	28	quantitation	quantitation	NOUN
admet-529	93	29	for	for	ADP
admet-529	93	30	the	the	DET
admet-529	93	31	concentration	concentration	NOUN
admet-529	93	32	of	of	ADP
admet-529	93	33	above	above	ADP
admet-529	93	34	1000	1000	NUM
admet-529	93	35	between	between	ADP
admet-529	93	36	phases	phase	NOUN
admet-529	93	37	.	.	PUNCT
admet-529	94	1	kihlberg	kihlberg	PROPN
admet-529	94	2	et	et	PROPN
admet-529	94	3	al	al	PROPN
admet-529	94	4	.	.	PROPN
admet-529	94	5	analyzed	analyze	VERB
admet-529	94	6	orally	orally	ADV
admet-529	94	7	available	available	ADJ
admet-529	94	8	drugs	drug	NOUN
admet-529	94	9	in	in	ADP
admet-529	94	10	bro5	bro5	NOUN
admet-529	94	11	space	space	NOUN
admet-529	94	12	[	[	X
admet-529	94	13	36	36	NUM
admet-529	94	14	]	]	PUNCT
admet-529	94	15	and	and	CCONJ
admet-529	94	16	observed	observe	VERB
admet-529	94	17	significant	significant	ADJ
admet-529	94	18	extension	extension	NOUN
admet-529	94	19	,	,	PUNCT
admet-529	94	20	almost	almost	ADV
admet-529	94	21	doubling	double	VERB
admet-529	94	22	in	in	ADP
admet-529	94	23	values	value	NOUN
admet-529	94	24	of	of	ADP
admet-529	94	25	ro5	ro5	ADJ
admet-529	94	26	parameters	parameter	NOUN
admet-529	94	27	(	(	PUNCT
admet-529	94	28	figure	figure	NOUN
admet-529	94	29	2	2	NUM
admet-529	94	30	)	)	PUNCT
admet-529	94	31	.	.	PUNCT
admet-529	95	1	they	they	PRON
admet-529	95	2	proposed	propose	VERB
admet-529	95	3	an	an	DET
admet-529	95	4	“	"	PUNCT
admet-529	95	5	extended	extended	ADJ
admet-529	95	6	ro5	ro5	ADJ
admet-529	95	7	space	space	NOUN
admet-529	95	8	”	"	PUNCT
admet-529	95	9	(	(	PUNCT
admet-529	95	10	mw	mw	X
admet-529	95	11	<	<	X
admet-529	95	12	700	700	NUM
admet-529	95	13	,	,	PUNCT
admet-529	95	14	0	0	NUM
admet-529	95	15	<	<	X
admet-529	95	16	clogp	clogp	NOUN
admet-529	95	17	<	<	X
admet-529	95	18	7.5	7.5	NUM
admet-529	95	19	,	,	PUNCT
admet-529	95	20	hbd	hbd	NOUN
admet-529	95	21	<	<	X
admet-529	95	22	5	5	NUM
admet-529	95	23	,	,	PUNCT
admet-529	95	24	psa	psa	VERB
admet-529	95	25	<	<	X
admet-529	95	26	200	200	NUM
admet-529	95	27	å2	å2	NOUN
admet-529	95	28	,	,	PUNCT
admet-529	95	29	and	and	CCONJ
admet-529	95	30	the	the	DET
admet-529	95	31	number	number	NOUN
admet-529	95	32	of	of	ADP
admet-529	95	33	rotatable	rotatable	ADJ
admet-529	95	34	bonds	bond	NOUN
admet-529	95	35	(	(	PUNCT
admet-529	95	36	nrotb	nrotb	NOUN
admet-529	95	37	)	)	PUNCT
admet-529	95	38	<	<	X
admet-529	95	39	20	20	NUM
admet-529	95	40	.	.	PUNCT
admet-529	96	1	they	they	PRON
admet-529	96	2	also	also	ADV
admet-529	96	3	proposed	propose	VERB
admet-529	96	4	a	a	PRON
admet-529	96	5	substantially	substantially	ADV
admet-529	96	6	larger	large	ADJ
admet-529	96	7	‘	'	PUNCT
admet-529	96	8	‘	'	PUNCT
admet-529	96	9	possible	possible	ADJ
admet-529	96	10	to	to	PART
admet-529	96	11	be	be	AUX
admet-529	96	12	oral	oral	ADJ
admet-529	96	13	”	"	PUNCT
admet-529	96	14	bro5	bro5	NOUN
admet-529	96	15	space	space	NOUN
admet-529	96	16	with	with	ADP
admet-529	96	17	the	the	DET
admet-529	96	18	limits	limit	NOUN
admet-529	96	19	for	for	ADP
admet-529	96	20	oral	oral	ADJ
admet-529	96	21	bioavailability	bioavailability	NOUN
admet-529	96	22	extended	extend	VERB
admet-529	96	23	to	to	PART
admet-529	96	24	approximately	approximately	ADV
admet-529	96	25	mw	mw	VERB
admet-529	96	26	<	<	X
admet-529	96	27	1000	1000	NUM
admet-529	96	28	,	,	PUNCT
admet-529	96	29	-2	-2	NOUN
admet-529	96	30	<	<	X
admet-529	96	31	clogp	clogp	ADJ
admet-529	96	32	<	<	X
admet-529	96	33	10	10	NUM
admet-529	96	34	,	,	PUNCT
admet-529	96	35	hbd	hbd	NOUN
admet-529	96	36	<	<	X
admet-529	96	37	6	6	NUM
admet-529	96	38	,	,	PUNCT
admet-529	96	39	hba	hba	X
admet-529	96	40	<	<	X
admet-529	96	41	15	15	NUM
admet-529	96	42	,	,	PUNCT
admet-529	96	43	psa	psa	VERB
admet-529	96	44	<	<	X
admet-529	96	45	250	250	NUM
admet-529	96	46	å2	å2	NOUN
admet-529	96	47	,	,	PUNCT
admet-529	96	48	nrotb	nrotb	NOUN
admet-529	96	49	<	<	X
admet-529	96	50	20	20	NUM
admet-529	96	51	(	(	PUNCT
admet-529	96	52	dashed	dash	VERB
admet-529	96	53	box	box	NOUN
admet-529	96	54	)	)	PUNCT
admet-529	96	55	.	.	PUNCT
admet-529	97	1	notably	notably	ADV
admet-529	97	2	,	,	PUNCT
admet-529	97	3	hbd	hbd	PROPN
admet-529	97	4	has	have	AUX
admet-529	97	5	hardly	hardly	ADV
admet-529	97	6	changed	change	VERB
admet-529	97	7	(	(	PUNCT
admet-529	97	8	increased	increase	VERB
admet-529	97	9	by	by	ADP
admet-529	97	10	only	only	ADV
admet-529	97	11	1	1	NUM
admet-529	97	12	count	count	NOUN
admet-529	97	13	)	)	PUNCT
admet-529	97	14	highlighting	highlight	VERB
admet-529	97	15	the	the	DET
admet-529	97	16	significance	significance	NOUN
admet-529	97	17	of	of	ADP
admet-529	97	18	limiting	limit	VERB
admet-529	97	19	hbd	hbd	NOUN
admet-529	97	20	exposure	exposure	NOUN
admet-529	97	21	for	for	ADP
admet-529	97	22	oral	oral	ADJ
admet-529	97	23	absorption	absorption	NOUN
admet-529	97	24	of	of	ADP
admet-529	97	25	large	large	ADJ
admet-529	97	26	molecules	molecule	NOUN
admet-529	97	27	.	.	PUNCT
admet-529	98	1	admet	admet	PROPN
admet-529	98	2	&	&	CCONJ
admet-529	98	3	dmpk	dmpk	PROPN
admet-529	98	4	6(2	6(2	NUM
admet-529	98	5	)	)	PUNCT
admet-529	98	6	(	(	PUNCT
admet-529	98	7	2018	2018	NUM
admet-529	98	8	)	)	PUNCT
admet-529	98	9	85	85	NUM
admet-529	98	10	-	-	SYM
admet-529	98	11	104	104	NUM
admet-529	98	12	leveraging	leverage	VERB
admet-529	98	13	chromatography	chromatography	NOUN
admet-529	98	14	physchem	physchem	NOUN
admet-529	98	15	properties	property	NOUN
admet-529	98	16	in	in	ADP
admet-529	98	17	drug	drug	NOUN
admet-529	98	18	design	design	NOUN
admet-529	98	19	doi	doi	NOUN
admet-529	98	20	:	:	PUNCT
admet-529	98	21	10.5599	10.5599	NUM
admet-529	98	22	/	/	SYM
admet-529	98	23	admet.529	admet.529	NOUN
admet-529	98	24	89	89	NUM
admet-529	98	25	figure	figure	NOUN
admet-529	98	26	2	2	NUM
admet-529	98	27	.	.	NOUN
admet-529	98	28	physicochemical	physicochemical	ADJ
admet-529	98	29	property	property	NOUN
admet-529	98	30	space	space	NOUN
admet-529	98	31	of	of	ADP
admet-529	98	32	drugs	drug	NOUN
admet-529	98	33	and	and	CCONJ
admet-529	98	34	clinical	clinical	ADJ
admet-529	98	35	candidates	candidate	NOUN
admet-529	98	36	with	with	ADP
admet-529	98	37	mw	mw	PROPN
admet-529	98	38	>	>	X
admet-529	98	39	500	500	NUM
admet-529	98	40	.	.	PUNCT
admet-529	99	1	solid	solid	ADJ
admet-529	99	2	box	box	PROPN
admet-529	99	3	marks	mark	NOUN
admet-529	99	4	“	"	PUNCT
admet-529	99	5	extended	extended	ADJ
admet-529	99	6	ro5	ro5	NOUN
admet-529	99	7	”	"	PUNCT
admet-529	99	8	space	space	NOUN
admet-529	99	9	.	.	PUNCT
admet-529	99	10	dashed	dash	VERB
admet-529	99	11	box	box	NOUN
admet-529	99	12	marks	mark	NOUN
admet-529	99	13	“	"	PUNCT
admet-529	99	14	bro5	bro5	NOUN
admet-529	99	15	”	"	PUNCT
admet-529	99	16	space	space	NOUN
admet-529	99	17	.	.	PUNCT
admet-529	100	1	reprinted	reprint	VERB
admet-529	100	2	from	from	ADP
admet-529	100	3	[	[	X
admet-529	100	4	36	36	NUM
admet-529	100	5	]	]	X
admet-529	100	6	copyright	copyright	NOUN
admet-529	100	7	(	(	PUNCT
admet-529	100	8	2014	2014	NUM
admet-529	100	9	)	)	PUNCT
admet-529	100	10	,	,	PUNCT
admet-529	100	11	with	with	ADP
admet-529	100	12	permission	permission	NOUN
admet-529	100	13	from	from	ADP
admet-529	100	14	elsevier	elsevier	PROPN
admet-529	100	15	.	.	PUNCT
admet-529	101	1	wang	wang	PROPN
admet-529	101	2	et	et	PROPN
admet-529	101	3	al	al	PROPN
admet-529	101	4	.	.	PUNCT
admet-529	102	1	[	[	X
admet-529	102	2	37	37	NUM
admet-529	102	3	]	]	PUNCT
admet-529	102	4	observed	observe	VERB
admet-529	102	5	a	a	DET
admet-529	102	6	correlation	correlation	NOUN
admet-529	102	7	of	of	ADP
admet-529	102	8	rp	rp	NOUN
admet-529	102	9	hplc	hplc	PROPN
admet-529	102	10	log	log	VERB
admet-529	102	11	k	k	NOUN
admet-529	102	12	’	'	PUNCT
admet-529	102	13	with	with	ADP
admet-529	102	14	passive	passive	ADJ
admet-529	102	15	permeability	permeability	NOUN
admet-529	102	16	determined	determine	VERB
admet-529	102	17	by	by	ADP
admet-529	102	18	human	human	ADJ
admet-529	102	19	colorectal	colorectal	ADJ
admet-529	102	20	adenocarcinoma	adenocarcinoma	NOUN
admet-529	102	21	cells	cell	NOUN
admet-529	102	22	(	(	PUNCT
admet-529	102	23	caco-2	caco-2	NUM
admet-529	102	24	)	)	PUNCT
admet-529	102	25	and	and	CCONJ
admet-529	102	26	the	the	DET
admet-529	102	27	parallel	parallel	ADJ
admet-529	102	28	artificial	artificial	ADJ
admet-529	102	29	membrane	membrane	NOUN
admet-529	102	30	permeability	permeability	NOUN
admet-529	102	31	assay	assay	NOUN
admet-529	102	32	(	(	PUNCT
admet-529	102	33	pampa	pampa	PROPN
admet-529	102	34	)	)	PUNCT
admet-529	102	35	for	for	ADP
admet-529	102	36	a	a	DET
admet-529	102	37	set	set	NOUN
admet-529	102	38	of	of	ADP
admet-529	102	39	macrocyclic	macrocyclic	NOUN
admet-529	102	40	peptides	peptide	NOUN
admet-529	102	41	.	.	PUNCT
admet-529	103	1	bockus	bockus	NOUN
admet-529	104	1	et	et	PROPN
admet-529	104	2	al	al	PROPN
admet-529	104	3	.	.	PROPN
admet-529	105	1	used	use	VERB
admet-529	105	2	elog	elog	PROPN
admet-529	105	3	d	d	PROPN
admet-529	105	4	(	(	PUNCT
admet-529	105	5	5.5	5.5	NUM
admet-529	105	6	to	to	PART
admet-529	105	7	7.5	7.5	NUM
admet-529	105	8	)	)	PUNCT
admet-529	105	9	to	to	PART
admet-529	105	10	study	study	VERB
admet-529	105	11	macrocycles	macrocycle	NOUN
admet-529	105	12	.	.	PUNCT
admet-529	106	1	the	the	DET
admet-529	106	2	lipophilicity	lipophilicity	NOUN
admet-529	106	3	values	value	NOUN
admet-529	106	4	correlated	correlate	VERB
admet-529	106	5	with	with	ADP
admet-529	106	6	cell	cell	NOUN
admet-529	106	7	-	-	PUNCT
admet-529	106	8	based	base	VERB
admet-529	106	9	permeability	permeability	NOUN
admet-529	106	10	values	value	NOUN
admet-529	106	11	by	by	ADP
admet-529	106	12	madin	madin	PROPN
admet-529	106	13	-	-	PUNCT
admet-529	106	14	darby	darby	PROPN
admet-529	106	15	canine	canine	PROPN
admet-529	106	16	kidney	kidney	NOUN
admet-529	106	17	(	(	PUNCT
admet-529	106	18	mdck)low	mdck)low	NOUN
admet-529	106	19	efflux	efflux	NOUN
admet-529	106	20	cells	cell	NOUN
admet-529	106	21	(	(	PUNCT
admet-529	106	22	mdck	mdck	NOUN
admet-529	106	23	-	-	PUNCT
admet-529	106	24	le	le	NOUN
admet-529	106	25	)	)	PUNCT
admet-529	107	1	[	[	X
admet-529	107	2	38	38	NUM
admet-529	107	3	]	]	PUNCT
admet-529	107	4	.	.	PUNCT
admet-529	108	1	lokey	lokey	PROPN
admet-529	108	2	et	et	PROPN
admet-529	108	3	al	al	PROPN
admet-529	108	4	.	.	PROPN
admet-529	108	5	investigated	investigate	VERB
admet-529	108	6	ro5	ro5	NOUN
admet-529	108	7	and	and	CCONJ
admet-529	108	8	bro5	bro5	NOUN
admet-529	108	9	compounds	compound	NOUN
admet-529	108	10	with	with	ADP
admet-529	108	11	mw	mw	PROPN
admet-529	108	12	>	>	X
admet-529	108	13	1000	1000	NUM
admet-529	108	14	and	and	CCONJ
admet-529	108	15	demonstrated	demonstrate	VERB
admet-529	108	16	a	a	DET
admet-529	108	17	sharp	sharp	ADJ
admet-529	108	18	decline	decline	NOUN
admet-529	108	19	in	in	ADP
admet-529	108	20	apparent	apparent	ADJ
admet-529	108	21	passive	passive	ADJ
admet-529	108	22	permeability	permeability	NOUN
admet-529	108	23	for	for	ADP
admet-529	108	24	compounds	compound	NOUN
admet-529	108	25	with	with	ADP
admet-529	108	26	molecular	molecular	ADJ
admet-529	108	27	size	size	NOUN
admet-529	108	28	above	above	ADP
admet-529	108	29	750	750	NUM
admet-529	108	30	å	å	NOUN
admet-529	109	1	[	[	X
admet-529	109	2	39	39	NUM
admet-529	109	3	]	]	PUNCT
admet-529	109	4	.	.	PUNCT
admet-529	110	1	they	they	PRON
admet-529	110	2	also	also	ADV
admet-529	110	3	concluded	conclude	VERB
admet-529	110	4	that	that	SCONJ
admet-529	110	5	bulk	bulk	ADJ
admet-529	110	6	physical	physical	ADJ
admet-529	110	7	properties	property	NOUN
admet-529	110	8	contributing	contribute	VERB
admet-529	110	9	to	to	ADP
admet-529	110	10	passive	passive	ADJ
admet-529	110	11	permeability	permeability	NOUN
admet-529	110	12	could	could	AUX
admet-529	110	13	be	be	AUX
admet-529	110	14	approximated	approximate	VERB
admet-529	110	15	by	by	ADP
admet-529	110	16	lipophilicity	lipophilicity	NOUN
admet-529	110	17	and	and	CCONJ
admet-529	110	18	molecular	molecular	ADJ
admet-529	110	19	size	size	NOUN
admet-529	110	20	(	(	PUNCT
admet-529	110	21	log	log	NOUN
admet-529	110	22	khydrocarbon	khydrocarbon	NOUN
admet-529	110	23	/	/	SYM
admet-529	110	24	water	water	NOUN
admet-529	110	25	and	and	CCONJ
admet-529	110	26	mw	mw	X
admet-529	110	27	respectively	respectively	ADV
admet-529	110	28	)	)	PUNCT
admet-529	110	29	.	.	PUNCT
admet-529	111	1	molecular	molecular	ADJ
admet-529	111	2	size	size	NOUN
admet-529	111	3	relates	relate	VERB
admet-529	111	4	to	to	ADP
admet-529	111	5	passive	passive	ADJ
admet-529	111	6	permeability	permeability	NOUN
admet-529	111	7	with	with	ADP
admet-529	111	8	pka	pka	PROPN
admet-529	111	9	and	and	CCONJ
admet-529	111	10	aqueous	aqueous	ADJ
admet-529	111	11	solubility	solubility	NOUN
admet-529	111	12	also	also	ADV
admet-529	111	13	very	very	ADV
admet-529	111	14	important	important	ADJ
admet-529	111	15	properties	property	NOUN
admet-529	111	16	to	to	PART
admet-529	111	17	consider	consider	VERB
admet-529	111	18	.	.	PUNCT
admet-529	112	1	the	the	DET
admet-529	112	2	lipophilicity	lipophilicity	NOUN
admet-529	112	3	parameter	parameter	NOUN
admet-529	112	4	used	use	VERB
admet-529	112	5	by	by	ADP
admet-529	112	6	lokey	lokey	PROPN
admet-529	112	7	et	et	PROPN
admet-529	112	8	al	al	PROPN
admet-529	112	9	.	.	PUNCT
admet-529	113	1	(	(	PUNCT
admet-529	113	2	log	log	PROPN
admet-529	113	3	khydrocarbon	khydrocarbon	NOUN
admet-529	113	4	/	/	SYM
admet-529	113	5	water	water	NOUN
admet-529	113	6	)	)	PUNCT
admet-529	113	7	is	be	AUX
admet-529	113	8	lipophilicity	lipophilicity	NOUN
admet-529	113	9	measured	measure	VERB
admet-529	113	10	in	in	ADP
admet-529	113	11	a	a	DET
admet-529	113	12	non	non	ADJ
admet-529	113	13	-	-	ADJ
admet-529	113	14	polar	polar	ADJ
admet-529	113	15	environment	environment	NOUN
admet-529	113	16	and	and	CCONJ
admet-529	113	17	is	be	AUX
admet-529	113	18	different	different	ADJ
admet-529	113	19	from	from	ADP
admet-529	113	20	log	log	NOUN
admet-529	113	21	doctanol	doctanol	NOUN
admet-529	113	22	/	/	SYM
admet-529	113	23	water	water	NOUN
admet-529	113	24	.	.	PUNCT
admet-529	114	1	it	it	PRON
admet-529	114	2	has	have	AUX
admet-529	114	3	been	be	AUX
admet-529	114	4	shown	show	VERB
admet-529	114	5	to	to	PART
admet-529	114	6	correlate	correlate	VERB
admet-529	114	7	well	well	ADV
admet-529	114	8	with	with	ADP
admet-529	114	9	passive	passive	ADJ
admet-529	114	10	permeability	permeability	NOUN
admet-529	114	11	measured	measure	VERB
admet-529	114	12	by	by	ADP
admet-529	114	13	pampa	pampa	NOUN
admet-529	114	14	and	and	CCONJ
admet-529	114	15	mdck	mdck	PROPN
admet-529	114	16	-	-	PUNCT
admet-529	114	17	le	le	X
admet-529	114	18	.	.	PUNCT
admet-529	115	1	the	the	DET
admet-529	115	2	use	use	NOUN
admet-529	115	3	of	of	ADP
admet-529	115	4	δlog	δlog	NOUN
admet-529	115	5	p	p	PROPN
admet-529	115	6	=	=	PROPN
admet-529	115	7	log	log	VERB
admet-529	115	8	palkane	palkane	NOUN
admet-529	115	9	/	/	SYM
admet-529	115	10	water	water	NOUN
admet-529	115	11	–	–	PUNCT
admet-529	115	12	log	log	VERB
admet-529	115	13	poctanol	poctanol	NOUN
admet-529	115	14	/	/	SYM
admet-529	115	15	water	water	NOUN
admet-529	115	16	was	be	AUX
admet-529	115	17	first	first	ADV
admet-529	115	18	introduced	introduce	VERB
admet-529	115	19	by	by	ADP
admet-529	115	20	seiler	seiler	NOUN
admet-529	115	21	[	[	X
admet-529	115	22	40	40	NUM
admet-529	115	23	]	]	PUNCT
admet-529	115	24	and	and	CCONJ
admet-529	115	25	applied	apply	VERB
admet-529	115	26	to	to	PART
admet-529	115	27	improve	improve	VERB
admet-529	115	28	absorption	absorption	NOUN
admet-529	115	29	[	[	X
admet-529	115	30	41	41	NUM
admet-529	115	31	]	]	PUNCT
admet-529	115	32	,	,	PUNCT
admet-529	115	33	as	as	ADP
admet-529	115	34	a	a	DET
admet-529	115	35	guide	guide	NOUN
admet-529	115	36	in	in	ADP
admet-529	115	37	the	the	DET
admet-529	115	38	design	design	NOUN
admet-529	115	39	of	of	ADP
admet-529	115	40	novel	novel	ADJ
admet-529	115	41	brain	brain	NOUN
admet-529	115	42	-	-	PUNCT
admet-529	115	43	penetrating	penetrate	VERB
admet-529	115	44	h2	h2	NOUN
admet-529	115	45	antagonists	antagonist	NOUN
admet-529	115	46	[	[	X
admet-529	115	47	42	42	NUM
admet-529	115	48	]	]	PUNCT
admet-529	115	49	,	,	PUNCT
admet-529	115	50	or	or	CCONJ
admet-529	115	51	as	as	ADP
admet-529	115	52	a	a	DET
admet-529	115	53	measure	measure	NOUN
admet-529	115	54	of	of	ADP
admet-529	115	55	hbd	hbd	NOUN
admet-529	115	56	acidity	acidity	NOUN
admet-529	115	57	[	[	X
admet-529	115	58	43,44	43,44	X
admet-529	115	59	]	]	PUNCT
admet-529	115	60	.	.	PUNCT
admet-529	116	1	hydrogen	hydrogen	NOUN
admet-529	116	2	bonds	bond	NOUN
admet-529	116	3	characteristically	characteristically	ADV
admet-529	116	4	feature	feature	VERB
admet-529	116	5	binding	bind	VERB
admet-529	116	6	energies	energy	NOUN
admet-529	116	7	and	and	CCONJ
admet-529	116	8	contact	contact	NOUN
admet-529	116	9	distances	distance	NOUN
admet-529	116	10	that	that	PRON
admet-529	116	11	can	can	AUX
admet-529	116	12	lead	lead	VERB
admet-529	116	13	to	to	ADP
admet-529	116	14	large	large	ADJ
admet-529	116	15	variations	variation	NOUN
admet-529	116	16	even	even	ADV
admet-529	116	17	for	for	ADP
admet-529	116	18	a	a	DET
admet-529	116	19	single	single	ADJ
admet-529	116	20	donor	donor	NOUN
admet-529	116	21	-	-	PUNCT
admet-529	116	22	acceptor	acceptor	NOUN
admet-529	116	23	pair	pair	NOUN
admet-529	116	24	[	[	X
admet-529	116	25	45	45	NUM
admet-529	116	26	]	]	PUNCT
admet-529	116	27	.	.	PUNCT
admet-529	117	1	the	the	DET
admet-529	117	2	96	96	NUM
admet-529	117	3	-	-	PUNCT
admet-529	117	4	well	well	NOUN
admet-529	117	5	plate	plate	NOUN
admet-529	117	6	-	-	PUNCT
admet-529	117	7	based	base	VERB
admet-529	117	8	shake	shake	NOUN
admet-529	117	9	-	-	PUNCT
admet-529	117	10	flask	flask	NOUN
admet-529	117	11	log	log	NOUN
admet-529	117	12	ptoluene	ptoluene	NOUN
admet-529	117	13	/	/	SYM
admet-529	117	14	water	water	NOUN
admet-529	117	15	method	method	NOUN
admet-529	117	16	(	(	PUNCT
admet-529	117	17	ph	ph	NOUN
admet-529	117	18	1	1	NUM
admet-529	117	19	to	to	PART
admet-529	117	20	11	11	NUM
admet-529	117	21	)	)	PUNCT
admet-529	117	22	was	be	AUX
admet-529	117	23	developed	develop	VERB
admet-529	117	24	along	along	ADP
admet-529	117	25	with	with	ADP
admet-529	117	26	the	the	DET
admet-529	117	27	imhb	imhb	ADJ
admet-529	117	28	interpretation	interpretation	NOUN
admet-529	117	29	scheme	scheme	NOUN
admet-529	117	30	based	base	VERB
admet-529	117	31	on	on	ADP
admet-529	117	32	δlog	δlog	NOUN
admet-529	117	33	p	p	X
admet-529	118	1	[	[	X
admet-529	118	2	46	46	NUM
admet-529	118	3	]	]	PUNCT
admet-529	118	4	.	.	PUNCT
admet-529	119	1	this	this	DET
admet-529	119	2	method	method	NOUN
admet-529	119	3	allows	allow	VERB
admet-529	119	4	verification	verification	NOUN
admet-529	119	5	of	of	ADP
admet-529	119	6	molecular	molecular	ADJ
admet-529	119	7	conformations	conformation	NOUN
admet-529	119	8	predicted	predict	VERB
admet-529	119	9	by	by	ADP
admet-529	119	10	cosmo	cosmo	PROPN
admet-529	119	11	-	-	PUNCT
admet-529	119	12	rs	rs	NOUN
admet-529	119	13	software	software	NOUN
admet-529	119	14	[	[	X
admet-529	119	15	47	47	NUM
admet-529	119	16	]	]	PUNCT
admet-529	119	17	which	which	PRON
admet-529	119	18	describes	describe	VERB
admet-529	119	19	the	the	DET
admet-529	119	20	geometry	geometry	NOUN
admet-529	119	21	of	of	ADP
admet-529	119	22	virtual	virtual	ADJ
admet-529	119	23	molecules	molecule	NOUN
admet-529	119	24	'	'	PART
admet-529	119	25	interactions	interaction	NOUN
admet-529	119	26	in	in	ADP
admet-529	119	27	both	both	CCONJ
admet-529	119	28	polar	polar	ADJ
admet-529	119	29	and	and	CCONJ
admet-529	119	30	non	non	ADJ
admet-529	119	31	-	-	ADJ
admet-529	119	32	polar	polar	ADJ
admet-529	119	33	environments	environment	NOUN
admet-529	119	34	.	.	PUNCT
admet-529	120	1	furthermore	furthermore	ADV
admet-529	120	2	,	,	PUNCT
admet-529	120	3	an	an	DET
admet-529	120	4	rp	rp	NOUN
admet-529	120	5	hplc	hplc	NOUN
admet-529	120	6	method	method	NOUN
admet-529	120	7	using	use	VERB
admet-529	120	8	a	a	DET
admet-529	120	9	polystyrene	polystyrene	NOUN
admet-529	120	10	-	-	PUNCT
admet-529	120	11	divinylbenzene	divinylbenzene	NOUN
admet-529	120	12	stationary	stationary	ADJ
admet-529	120	13	phase	phase	NOUN
admet-529	120	14	(	(	PUNCT
admet-529	120	15	plrp	plrp	NOUN
admet-529	120	16	-	-	PUNCT
admet-529	120	17	s	s	NOUN
admet-529	120	18	)	)	PUNCT
admet-529	120	19	was	be	AUX
admet-529	120	20	developed	develop	VERB
admet-529	120	21	to	to	PART
admet-529	120	22	simulate	simulate	VERB
admet-529	120	23	a	a	DET
admet-529	120	24	non	non	ADJ
admet-529	120	25	-	-	ADJ
admet-529	120	26	polar	polar	ADJ
admet-529	120	27	lipidic	lipidic	ADJ
admet-529	120	28	membrane	membrane	NOUN
admet-529	120	29	environment	environment	NOUN
admet-529	120	30	[	[	X
admet-529	120	31	48	48	NUM
admet-529	120	32	]	]	PUNCT
admet-529	120	33	,	,	PUNCT
admet-529	120	34	and	and	CCONJ
admet-529	120	35	to	to	PART
admet-529	120	36	obtain	obtain	VERB
admet-529	120	37	experimental	experimental	ADJ
admet-529	120	38	lipophilicity	lipophilicity	NOUN
admet-529	120	39	values	value	NOUN
admet-529	120	40	.	.	PUNCT
admet-529	121	1	kihlberg	kihlberg	PROPN
admet-529	121	2	et	et	PROPN
admet-529	121	3	al	al	PROPN
admet-529	121	4	described	describe	VERB
admet-529	121	5	errors	error	NOUN
admet-529	121	6	in	in	ADP
admet-529	121	7	clogp	clogp	NOUN
admet-529	121	8	;	;	PUNCT
admet-529	121	9	log	log	VERB
admet-529	121	10	poct	poct	NOUN
admet-529	121	11	predictions	prediction	NOUN
admet-529	121	12	that	that	PRON
admet-529	121	13	were	be	AUX
admet-529	121	14	far	far	ADV
admet-529	121	15	from	from	ADP
admet-529	121	16	the	the	DET
admet-529	121	17	experimentally	experimentally	ADV
admet-529	121	18	determined	determine	VERB
admet-529	121	19	values	value	NOUN
admet-529	121	20	[	[	X
admet-529	121	21	36	36	NUM
admet-529	121	22	]	]	PUNCT
admet-529	121	23	.	.	PUNCT
admet-529	122	1	posaconazole	posaconazole	PROPN
admet-529	122	2	has	have	VERB
admet-529	122	3	a	a	DET
admet-529	122	4	clogp	clogp	NOUN
admet-529	122	5	of	of	ADP
admet-529	122	6	5.4	5.4	NUM
admet-529	122	7	,	,	PUNCT
admet-529	122	8	while	while	SCONJ
admet-529	122	9	the	the	DET
admet-529	122	10	experimentally	experimentally	ADV
admet-529	122	11	determined	determine	VERB
admet-529	122	12	log	log	NOUN
admet-529	122	13	p	p	NOUN
admet-529	122	14	is	be	AUX
admet-529	122	15	2.4	2.4	NUM
admet-529	122	16	[	[	SYM
admet-529	122	17	49	49	NUM
admet-529	122	18	]	]	PUNCT
admet-529	122	19	.	.	PUNCT
admet-529	123	1	however	however	ADV
admet-529	123	2	,	,	PUNCT
admet-529	123	3	in	in	ADP
admet-529	123	4	this	this	DET
admet-529	123	5	particular	particular	ADJ
admet-529	123	6	case	case	NOUN
admet-529	123	7	,	,	PUNCT
admet-529	123	8	the	the	DET
admet-529	123	9	measured	measured	ADJ
admet-529	123	10	value	value	NOUN
admet-529	123	11	may	may	AUX
admet-529	123	12	be	be	AUX
admet-529	123	13	incorrect	incorrect	ADJ
admet-529	123	14	.	.	PUNCT
admet-529	124	1	these	these	DET
admet-529	124	2	studies	study	NOUN
admet-529	124	3	reiterate	reiterate	VERB
admet-529	124	4	the	the	DET
admet-529	124	5	need	need	NOUN
admet-529	124	6	for	for	ADP
admet-529	124	7	an	an	DET
admet-529	124	8	extended	extended	ADJ
admet-529	124	9	range	range	NOUN
admet-529	124	10	of	of	ADP
admet-529	124	11	lipophilicity	lipophilicity	NOUN
admet-529	124	12	measurements	measurement	NOUN
admet-529	124	13	for	for	ADP
admet-529	124	14	bro5	bro5	NOUN
admet-529	124	15	compounds	compound	NOUN
admet-529	124	16	that	that	PRON
admet-529	124	17	would	would	AUX
admet-529	124	18	accommodate	accommodate	VERB
admet-529	124	19	the	the	DET
admet-529	124	20	large	large	ADJ
admet-529	124	21	lipophilic	lipophilic	ADJ
admet-529	124	22	molecules	molecule	NOUN
admet-529	124	23	designed	design	VERB
admet-529	124	24	for	for	ADP
admet-529	124	25	current	current	ADJ
admet-529	124	26	targets	target	NOUN
admet-529	124	27	.	.	PUNCT
admet-529	125	1	they	they	PRON
admet-529	125	2	highlight	highlight	VERB
admet-529	125	3	the	the	DET
admet-529	125	4	importance	importance	NOUN
admet-529	125	5	of	of	ADP
admet-529	125	6	lipophilicity	lipophilicity	NOUN
admet-529	125	7	as	as	ADP
admet-529	125	8	an	an	DET
admet-529	125	9	approximation	approximation	NOUN
admet-529	125	10	of	of	ADP
admet-529	125	11	molecular	molecular	ADJ
admet-529	125	12	size	size	NOUN
admet-529	125	13	and	and	CCONJ
admet-529	125	14	conformations	conformation	NOUN
admet-529	125	15	in	in	ADP
admet-529	125	16	specific	specific	ADJ
admet-529	125	17	environments	environment	NOUN
admet-529	125	18	.	.	PUNCT
admet-529	126	1	g.h	g.h	PROPN
admet-529	126	2	.	.	PROPN
admet-529	127	1	goetz	goetz	PROPN
admet-529	127	2	and	and	CCONJ
admet-529	127	3	m.	m.	NOUN
admet-529	127	4	shalaeva	shalaeva	PROPN
admet-529	127	5	admet	admet	PROPN
admet-529	127	6	&	&	CCONJ
admet-529	127	7	dmpk	dmpk	PROPN
admet-529	127	8	6(2	6(2	NUM
admet-529	127	9	)	)	PUNCT
admet-529	127	10	(	(	PUNCT
admet-529	127	11	2018	2018	NUM
admet-529	127	12	)	)	PUNCT
admet-529	127	13	85	85	NUM
admet-529	127	14	-	-	SYM
admet-529	127	15	104	104	NUM
admet-529	127	16	90	90	NUM
admet-529	127	17	lipophilicity	lipophilicity	NOUN
admet-529	127	18	and	and	CCONJ
admet-529	127	19	clearance	clearance	NOUN
admet-529	127	20	avoiding	avoid	VERB
admet-529	127	21	highly	highly	ADV
admet-529	127	22	lipophilic	lipophilic	ADJ
admet-529	127	23	compounds	compound	NOUN
admet-529	127	24	is	be	AUX
admet-529	127	25	a	a	DET
admet-529	127	26	design	design	NOUN
admet-529	127	27	principle	principle	NOUN
admet-529	127	28	used	use	VERB
admet-529	127	29	to	to	PART
admet-529	127	30	improve	improve	VERB
admet-529	127	31	clearance	clearance	NOUN
admet-529	127	32	[	[	X
admet-529	127	33	50	50	NUM
admet-529	127	34	]	]	PUNCT
admet-529	127	35	.	.	PUNCT
admet-529	128	1	the	the	DET
admet-529	128	2	analysis	analysis	NOUN
admet-529	128	3	of	of	ADP
admet-529	128	4	matching	match	VERB
admet-529	128	5	pairs	pair	NOUN
admet-529	128	6	conducted	conduct	VERB
admet-529	128	7	by	by	ADP
admet-529	128	8	stepan	stepan	PROPN
admet-529	128	9	et	et	PROPN
admet-529	128	10	al	al	PROPN
admet-529	128	11	.	.	PUNCT
admet-529	129	1	[	[	X
admet-529	129	2	11	11	NUM
admet-529	129	3	]	]	PUNCT
admet-529	129	4	confirmed	confirm	VERB
admet-529	129	5	that	that	SCONJ
admet-529	129	6	changes	change	NOUN
admet-529	129	7	in	in	ADP
admet-529	129	8	metabolic	metabolic	NOUN
admet-529	129	9	stability	stability	NOUN
admet-529	129	10	largely	largely	ADV
admet-529	129	11	come	come	VERB
admet-529	129	12	from	from	ADP
admet-529	129	13	changes	change	NOUN
admet-529	129	14	in	in	ADP
admet-529	129	15	lipophilicity	lipophilicity	NOUN
admet-529	129	16	(	(	PUNCT
admet-529	129	17	figure	figure	NOUN
admet-529	129	18	3	3	NUM
admet-529	129	19	)	)	PUNCT
admet-529	129	20	.	.	PUNCT
admet-529	130	1	to	to	PART
admet-529	130	2	determine	determine	VERB
admet-529	130	3	how	how	SCONJ
admet-529	130	4	structural	structural	ADJ
admet-529	130	5	changes	change	NOUN
admet-529	130	6	affect	affect	VERB
admet-529	130	7	the	the	DET
admet-529	130	8	relative	relative	ADJ
admet-529	130	9	clearance	clearance	NOUN
admet-529	130	10	between	between	ADP
admet-529	130	11	analogues	analogue	NOUN
admet-529	130	12	,	,	PUNCT
admet-529	130	13	the	the	DET
admet-529	130	14	lipophilic	lipophilic	ADJ
admet-529	130	15	metabolism	metabolism	NOUN
admet-529	130	16	efficiency	efficiency	NOUN
admet-529	130	17	parameter	parameter	NOUN
admet-529	130	18	(	(	PUNCT
admet-529	130	19	lipmete	lipmete	PROPN
admet-529	130	20	)	)	PUNCT
admet-529	130	21	was	be	AUX
admet-529	130	22	introduced	introduce	VERB
admet-529	130	23	.	.	PUNCT
admet-529	131	1	lipmete	lipmete	ADJ
admet-529	131	2	relates	relate	VERB
admet-529	131	3	lipophilicity	lipophilicity	NOUN
admet-529	131	4	to	to	ADP
admet-529	131	5	the	the	DET
admet-529	131	6	in	in	X
admet-529	131	7	vitro	vitro	X
admet-529	131	8	metabolic	metabolic	NOUN
admet-529	131	9	clearance	clearance	NOUN
admet-529	131	10	measured	measure	VERB
admet-529	131	11	by	by	ADP
admet-529	131	12	the	the	DET
admet-529	131	13	human	human	ADJ
admet-529	131	14	liver	liver	NOUN
admet-529	131	15	microsomes	microsome	NOUN
admet-529	131	16	(	(	PUNCT
admet-529	131	17	hlm	hlm	PROPN
admet-529	131	18	)	)	PUNCT
admet-529	131	19	assay	assay	NOUN
admet-529	131	20	.	.	PUNCT
admet-529	132	1	lipmete	lipmete	ADJ
admet-529	132	2	and	and	CCONJ
admet-529	132	3	unbound	unbound	NOUN
admet-529	132	4	clearance	clearance	NOUN
admet-529	132	5	(	(	PUNCT
admet-529	132	6	clint	clint	NOUN
admet-529	132	7	,	,	PUNCT
admet-529	132	8	u	u	NOUN
admet-529	132	9	)	)	PUNCT
admet-529	132	10	are	be	AUX
admet-529	132	11	defined	define	VERB
admet-529	132	12	as	as	SCONJ
admet-529	132	13	follows	follow	VERB
admet-529	132	14	:	:	PUNCT
admet-529	132	15	lipmete	lipmete	ADJ
admet-529	132	16	=	=	PUNCT
admet-529	132	17	log	log	NOUN
admet-529	132	18	d7.4	d7.4	NOUN
admet-529	132	19	−	−	NOUN
admet-529	132	20	log	log	NOUN
admet-529	132	21	(	(	PUNCT
admet-529	132	22	clint	clint	NOUN
admet-529	132	23	,	,	PUNCT
admet-529	132	24	u	u	NOUN
admet-529	132	25	)	)	PUNCT
admet-529	132	26	,	,	PUNCT
admet-529	132	27	clint	clint	NOUN
admet-529	132	28	,	,	PUNCT
admet-529	132	29	u	u	NOUN
admet-529	132	30	=	=	PROPN
admet-529	132	31	clint	clint	PROPN
admet-529	132	32	,	,	PUNCT
admet-529	132	33	app	app	PROPN
admet-529	132	34	/	/	SYM
admet-529	132	35	fu	fu	PROPN
admet-529	132	36	,	,	PUNCT
admet-529	132	37	mic	mic	ADJ
admet-529	132	38	.	.	PUNCT
admet-529	133	1	figure	figure	NOUN
admet-529	133	2	3	3	NUM
admet-529	133	3	.	.	PUNCT
admet-529	134	1	the	the	DET
admet-529	134	2	plot	plot	NOUN
admet-529	134	3	of	of	ADP
admet-529	134	4	unbound	unbound	NOUN
admet-529	134	5	clearance	clearance	NOUN
admet-529	134	6	,	,	PUNCT
admet-529	134	7	clint	clint	NOUN
admet-529	134	8	,	,	PUNCT
admet-529	134	9	u	u	NOUN
admet-529	134	10	,	,	PUNCT
admet-529	134	11	versus	versus	ADP
admet-529	134	12	experimental	experimental	ADJ
admet-529	134	13	log	log	PROPN
admet-529	134	14	d	d	PROPN
admet-529	134	15	,	,	PUNCT
admet-529	134	16	elog	elog	PROPN
admet-529	134	17	d.	d.	PROPN
admet-529	134	18	the	the	DET
admet-529	134	19	45	45	NUM
admet-529	134	20	°	°	PROPN
admet-529	134	21	lines	line	NOUN
admet-529	134	22	represent	represent	VERB
admet-529	134	23	different	different	ADJ
admet-529	134	24	values	value	NOUN
admet-529	134	25	of	of	ADP
admet-529	134	26	lipmete	lipmete	ADJ
admet-529	134	27	.	.	PUNCT
admet-529	135	1	compounds	compound	VERB
admet-529	135	2	that	that	PRON
admet-529	135	3	parallel	parallel	VERB
admet-529	135	4	the	the	DET
admet-529	135	5	same	same	ADJ
admet-529	135	6	45	45	NUM
admet-529	135	7	°	°	PROPN
admet-529	135	8	line	line	NOUN
admet-529	135	9	offer	offer	VERB
admet-529	135	10	the	the	DET
admet-529	135	11	same	same	ADJ
admet-529	135	12	ratio	ratio	NOUN
admet-529	135	13	of	of	ADP
admet-529	135	14	metabolic	metabolic	NOUN
admet-529	135	15	clearance	clearance	NOUN
admet-529	135	16	to	to	ADP
admet-529	135	17	lipophilicity	lipophilicity	PROPN
admet-529	135	18	.	.	PUNCT
admet-529	136	1	reprinted	reprint	VERB
admet-529	136	2	with	with	ADP
admet-529	136	3	permission	permission	NOUN
admet-529	136	4	from	from	ADP
admet-529	136	5	[	[	X
admet-529	136	6	11	11	NUM
admet-529	136	7	]	]	PUNCT
admet-529	136	8	.	.	PUNCT
admet-529	137	1	copyright	copyright	NOUN
admet-529	137	2	(	(	PUNCT
admet-529	137	3	2013	2013	NUM
admet-529	137	4	)	)	PUNCT
admet-529	137	5	american	american	PROPN
admet-529	137	6	chemical	chemical	PROPN
admet-529	137	7	society	society	PROPN
admet-529	137	8	.	.	PUNCT
admet-529	138	1	stepan	stepan	PROPN
admet-529	138	2	et	et	PROPN
admet-529	138	3	al	al	PROPN
admet-529	138	4	.	.	PUNCT
admet-529	139	1	[	[	X
admet-529	139	2	11	11	NUM
admet-529	139	3	]	]	PUNCT
admet-529	139	4	suggested	suggest	VERB
admet-529	139	5	choosing	choose	VERB
admet-529	139	6	high	high	ADJ
admet-529	139	7	lipmete	lipmete	ADJ
admet-529	139	8	compounds	compound	NOUN
admet-529	139	9	as	as	ADP
admet-529	139	10	a	a	DET
admet-529	139	11	starting	starting	NOUN
admet-529	139	12	point	point	NOUN
admet-529	139	13	for	for	ADP
admet-529	139	14	optimization	optimization	NOUN
admet-529	139	15	due	due	ADP
admet-529	139	16	to	to	ADP
admet-529	139	17	their	their	PRON
admet-529	139	18	wider	wide	ADJ
admet-529	139	19	logd	logd	NOUN
admet-529	139	20	range	range	NOUN
admet-529	139	21	.	.	PUNCT
admet-529	140	1	thus	thus	ADV
admet-529	140	2	,	,	PUNCT
admet-529	140	3	potency	potency	NOUN
admet-529	140	4	and	and	CCONJ
admet-529	140	5	permeability	permeability	NOUN
admet-529	140	6	could	could	AUX
admet-529	140	7	be	be	AUX
admet-529	140	8	improved	improve	VERB
admet-529	140	9	while	while	SCONJ
admet-529	140	10	maintaining	maintain	VERB
admet-529	140	11	low	low	ADJ
admet-529	140	12	clearance	clearance	NOUN
admet-529	140	13	.	.	PUNCT
admet-529	141	1	lipe	lipe	PROPN
admet-529	141	2	and	and	CCONJ
admet-529	141	3	lipmete	lipmete	NOUN
admet-529	141	4	have	have	AUX
admet-529	141	5	become	become	VERB
admet-529	141	6	complementary	complementary	ADJ
admet-529	141	7	opposites	opposite	NOUN
admet-529	141	8	(	(	PUNCT
admet-529	141	9	“	"	PUNCT
admet-529	141	10	yin	yin	PROPN
admet-529	141	11	and	and	CCONJ
admet-529	141	12	yang	yang	PROPN
admet-529	141	13	”	"	PUNCT
admet-529	141	14	)	)	PUNCT
admet-529	141	15	in	in	ADP
admet-529	141	16	medicinal	medicinal	ADJ
admet-529	141	17	chemistry	chemistry	NOUN
admet-529	141	18	decision	decision	NOUN
admet-529	141	19	making	make	VERB
admet-529	141	20	at	at	ADP
admet-529	141	21	pfizer	pfizer	NOUN
admet-529	141	22	and	and	CCONJ
admet-529	141	23	the	the	DET
admet-529	141	24	authors	author	NOUN
admet-529	141	25	provide	provide	VERB
admet-529	141	26	specific	specific	ADJ
admet-529	141	27	guidance	guidance	NOUN
admet-529	141	28	on	on	ADP
admet-529	141	29	simultaneously	simultaneously	ADV
admet-529	141	30	optimizing	optimize	VERB
admet-529	141	31	these	these	DET
admet-529	141	32	lipophilicity	lipophilicity	NOUN
admet-529	141	33	driven	drive	VERB
admet-529	141	34	parameters	parameter	NOUN
admet-529	141	35	.	.	PUNCT
admet-529	142	1	optimization	optimization	NOUN
admet-529	142	2	of	of	ADP
admet-529	142	3	adme	adme	NOUN
admet-529	142	4	properties	property	NOUN
admet-529	142	5	,	,	PUNCT
admet-529	142	6	such	such	ADJ
admet-529	142	7	as	as	ADP
admet-529	142	8	cell	cell	NOUN
admet-529	142	9	membrane	membrane	NOUN
admet-529	142	10	permeability	permeability	NOUN
admet-529	142	11	and	and	CCONJ
admet-529	142	12	metabolic	metabolic	NOUN
admet-529	142	13	stability	stability	NOUN
admet-529	142	14	,	,	PUNCT
admet-529	142	15	often	often	ADV
admet-529	142	16	comes	come	VERB
admet-529	142	17	to	to	ADP
admet-529	142	18	an	an	DET
admet-529	142	19	act	act	NOUN
admet-529	142	20	of	of	ADP
admet-529	142	21	balancing	balance	VERB
admet-529	142	22	these	these	DET
admet-529	142	23	orthogonal	orthogonal	ADJ
admet-529	142	24	parameters	parameter	NOUN
admet-529	142	25	.	.	PUNCT
admet-529	143	1	gleeson	gleeson	NOUN
admet-529	143	2	[	[	X
admet-529	143	3	14	14	NUM
admet-529	143	4	]	]	PUNCT
admet-529	143	5	describes	describe	VERB
admet-529	143	6	the	the	DET
admet-529	143	7	contribution	contribution	NOUN
admet-529	143	8	of	of	ADP
admet-529	143	9	mw	mw	PROPN
admet-529	143	10	,	,	PUNCT
admet-529	143	11	ionization	ionization	NOUN
admet-529	143	12	state	state	NOUN
admet-529	143	13	,	,	PUNCT
admet-529	143	14	and	and	CCONJ
admet-529	143	15	clogp	clogp	VERB
admet-529	143	16	to	to	ADP
admet-529	143	17	in	in	ADP
admet-529	143	18	vivo	vivo	ADJ
admet-529	143	19	clearance	clearance	NOUN
admet-529	143	20	.	.	PUNCT
admet-529	144	1	log	log	NOUN
admet-529	144	2	clearance	clearance	NOUN
admet-529	144	3	(	(	PUNCT
admet-529	144	4	log	log	NOUN
admet-529	144	5	cl	cl	NOUN
admet-529	144	6	)	)	PUNCT
admet-529	144	7	was	be	AUX
admet-529	144	8	largest	large	ADJ
admet-529	144	9	for	for	ADP
admet-529	144	10	a	a	DET
admet-529	144	11	clogp	clogp	NOUN
admet-529	144	12	>	>	X
admet-529	144	13	5	5	NUM
admet-529	144	14	,	,	PUNCT
admet-529	144	15	less	less	ADV
admet-529	144	16	pronounced	pronounced	ADJ
admet-529	144	17	for	for	ADP
admet-529	144	18	clogp	clogp	ADJ
admet-529	144	19	3–5	3–5	NOUN
admet-529	144	20	,	,	PUNCT
admet-529	144	21	and	and	CCONJ
admet-529	144	22	most	most	ADV
admet-529	144	23	favorable	favorable	ADJ
admet-529	144	24	for	for	ADP
admet-529	144	25	a	a	DET
admet-529	144	26	clogp	clogp	NOUN
admet-529	144	27	<	<	X
admet-529	144	28	3	3	NUM
admet-529	144	29	.	.	X
admet-529	144	30	johnson	johnson	PROPN
admet-529	144	31	et	et	PROPN
admet-529	144	32	al	al	PROPN
admet-529	144	33	.	.	PUNCT
admet-529	145	1	[	[	X
admet-529	145	2	16	16	NUM
admet-529	145	3	]	]	PUNCT
admet-529	145	4	analyzed	analyze	VERB
admet-529	145	5	permeability	permeability	NOUN
admet-529	145	6	and	and	CCONJ
admet-529	145	7	clearance	clearance	NOUN
admet-529	145	8	data	datum	NOUN
admet-529	145	9	for	for	ADP
admet-529	145	10	47,018	47,018	NUM
admet-529	145	11	pfizer	pfizer	NOUN
admet-529	145	12	compounds	compound	NOUN
admet-529	145	13	and	and	CCONJ
admet-529	145	14	observed	observe	VERB
admet-529	145	15	broad	broad	ADJ
admet-529	145	16	trends	trend	NOUN
admet-529	145	17	for	for	ADP
admet-529	145	18	favorable	favorable	ADJ
admet-529	145	19	clearance	clearance	NOUN
admet-529	145	20	and	and	CCONJ
admet-529	145	21	permeability	permeability	NOUN
admet-529	145	22	compared	compare	VERB
admet-529	145	23	to	to	AUX
admet-529	145	24	mw	mw	VERB
admet-529	145	25	and	and	CCONJ
admet-529	145	26	log	log	VERB
admet-529	145	27	d.	d.	PROPN
admet-529	145	28	using	use	VERB
admet-529	145	29	lipophilicity	lipophilicity	NOUN
admet-529	145	30	determination	determination	NOUN
admet-529	145	31	,	,	PUNCT
admet-529	145	32	they	they	PRON
admet-529	145	33	identified	identify	VERB
admet-529	145	34	a	a	DET
admet-529	145	35	“	"	PUNCT
admet-529	145	36	golden	golden	ADJ
admet-529	145	37	triangle	triangle	NOUN
admet-529	145	38	”	"	PUNCT
admet-529	145	39	of	of	ADP
admet-529	145	40	mw	mw	NOUN
admet-529	145	41	and	and	CCONJ
admet-529	145	42	log	log	VERB
admet-529	145	43	d	d	NOUN
admet-529	145	44	values	value	NOUN
admet-529	145	45	for	for	ADP
admet-529	145	46	optimal	optimal	ADJ
admet-529	145	47	permeability	permeability	NOUN
admet-529	145	48	and	and	CCONJ
admet-529	145	49	metabolic	metabolic	NOUN
admet-529	145	50	stability	stability	NOUN
admet-529	145	51	.	.	PUNCT
admet-529	146	1	figure	figure	VERB
admet-529	146	2	4	4	NUM
admet-529	146	3	shows	show	VERB
admet-529	146	4	permeable	permeable	ADJ
admet-529	146	5	and	and	CCONJ
admet-529	146	6	stable	stable	ADJ
admet-529	146	7	compounds	compound	NOUN
admet-529	146	8	in	in	ADP
admet-529	146	9	blue	blue	ADJ
admet-529	146	10	and	and	CCONJ
admet-529	146	11	compounds	compound	VERB
admet-529	146	12	failing	fail	VERB
admet-529	146	13	permeability	permeability	NOUN
admet-529	146	14	or	or	CCONJ
admet-529	146	15	metabolic	metabolic	NOUN
admet-529	146	16	stability	stability	NOUN
admet-529	146	17	in	in	ADP
admet-529	146	18	grey	grey	NOUN
admet-529	146	19	against	against	ADP
admet-529	146	20	mw	mw	NOUN
admet-529	146	21	and	and	CCONJ
admet-529	146	22	log	log	VERB
admet-529	146	23	d.	d.	PROPN
admet-529	146	24	compounds	compound	VERB
admet-529	146	25	with	with	ADP
admet-529	146	26	favorable	favorable	ADJ
admet-529	146	27	clearance	clearance	NOUN
admet-529	146	28	and	and	CCONJ
admet-529	146	29	permeability	permeability	NOUN
admet-529	146	30	properties	property	NOUN
admet-529	146	31	are	be	AUX
admet-529	146	32	clustered	cluster	VERB
admet-529	146	33	within	within	ADP
admet-529	146	34	this	this	DET
admet-529	146	35	“	"	PUNCT
admet-529	146	36	golden	golden	ADJ
admet-529	146	37	triangle	triangle	NOUN
admet-529	146	38	”	"	PUNCT
admet-529	146	39	of	of	ADP
admet-529	146	40	mw	mw	NOUN
admet-529	146	41	and	and	CCONJ
admet-529	146	42	log	log	VERB
admet-529	146	43	d.	d.	PROPN
admet-529	146	44	admet	admet	PROPN
admet-529	146	45	&	&	CCONJ
admet-529	146	46	dmpk	dmpk	PROPN
admet-529	146	47	6(2	6(2	NUM
admet-529	146	48	)	)	PUNCT
admet-529	146	49	(	(	PUNCT
admet-529	146	50	2018	2018	NUM
admet-529	146	51	)	)	PUNCT
admet-529	146	52	85	85	NUM
admet-529	146	53	-	-	SYM
admet-529	146	54	104	104	NUM
admet-529	146	55	leveraging	leverage	VERB
admet-529	146	56	chromatography	chromatography	NOUN
admet-529	146	57	physchem	physchem	NOUN
admet-529	146	58	properties	property	NOUN
admet-529	146	59	in	in	ADP
admet-529	146	60	drug	drug	NOUN
admet-529	146	61	design	design	NOUN
admet-529	146	62	doi	doi	NOUN
admet-529	146	63	:	:	PUNCT
admet-529	146	64	10.5599	10.5599	NUM
admet-529	146	65	/	/	SYM
admet-529	146	66	admet.529	admet.529	NOUN
admet-529	146	67	91	91	NUM
admet-529	146	68	figure	figure	NOUN
admet-529	146	69	4	4	NUM
admet-529	146	70	.	.	PUNCT
admet-529	146	71	combined	combine	VERB
admet-529	146	72	in	in	ADP
admet-529	146	73	vitro	vitro	X
admet-529	146	74	permeability	permeability	NOUN
admet-529	146	75	and	and	CCONJ
admet-529	146	76	clearance	clearance	NOUN
admet-529	146	77	trends	trend	NOUN
admet-529	146	78	across	across	ADP
admet-529	146	79	mw	mw	NOUN
admet-529	146	80	and	and	CCONJ
admet-529	146	81	log	log	PROPN
admet-529	146	82	d.	d.	PROPN
admet-529	146	83	reprinted	reprint	VERB
admet-529	146	84	from	from	ADP
admet-529	146	85	[	[	X
admet-529	146	86	16	16	NUM
admet-529	146	87	]	]	X
admet-529	146	88	copyright	copyright	NOUN
admet-529	146	89	(	(	PUNCT
admet-529	146	90	2009	2009	NUM
admet-529	146	91	)	)	PUNCT
admet-529	146	92	,	,	PUNCT
admet-529	146	93	with	with	ADP
admet-529	146	94	permission	permission	NOUN
admet-529	146	95	from	from	ADP
admet-529	146	96	elsevier	elsevier	PROPN
admet-529	146	97	.	.	PUNCT
admet-529	147	1	lipophilicity	lipophilicity	NOUN
admet-529	147	2	and	and	CCONJ
admet-529	147	3	toxicity	toxicity	NOUN
admet-529	147	4	avoiding	avoid	VERB
admet-529	147	5	high	high	ADJ
admet-529	147	6	lipophilicity	lipophilicity	NOUN
admet-529	147	7	is	be	AUX
admet-529	147	8	also	also	ADV
admet-529	147	9	critical	critical	ADJ
admet-529	147	10	for	for	ADP
admet-529	147	11	reducing	reduce	VERB
admet-529	147	12	the	the	DET
admet-529	147	13	probability	probability	NOUN
admet-529	147	14	of	of	ADP
admet-529	147	15	adverse	adverse	ADJ
admet-529	147	16	safety	safety	NOUN
admet-529	147	17	findings	finding	NOUN
admet-529	147	18	[	[	X
admet-529	147	19	3	3	NUM
admet-529	147	20	,	,	PUNCT
admet-529	147	21	51	51	NUM
admet-529	147	22	]	]	PUNCT
admet-529	147	23	.	.	PUNCT
admet-529	148	1	hughes	hughes	PROPN
admet-529	148	2	et	et	PROPN
admet-529	148	3	al	al	PROPN
admet-529	148	4	.	.	PUNCT
admet-529	149	1	[	[	X
admet-529	149	2	52	52	NUM
admet-529	149	3	]	]	PUNCT
admet-529	149	4	demonstrated	demonstrate	VERB
admet-529	149	5	that	that	SCONJ
admet-529	149	6	lipophilic	lipophilic	ADJ
admet-529	149	7	compounds	compound	NOUN
admet-529	149	8	(	(	PUNCT
admet-529	149	9	clogp	clogp	ADJ
admet-529	149	10	>	>	X
admet-529	149	11	3	3	NUM
admet-529	149	12	)	)	PUNCT
admet-529	149	13	with	with	ADP
admet-529	149	14	a	a	DET
admet-529	149	15	low	low	ADJ
admet-529	149	16	polar	polar	ADJ
admet-529	149	17	surface	surface	NOUN
admet-529	149	18	area	area	NOUN
admet-529	149	19	(	(	PUNCT
admet-529	149	20	psa	psa	VERB
admet-529	149	21	<	<	X
admet-529	149	22	75	75	NUM
admet-529	149	23	å2	å2	NOUN
admet-529	149	24	)	)	PUNCT
admet-529	149	25	have	have	VERB
admet-529	149	26	a	a	DET
admet-529	149	27	6	6	NUM
admet-529	149	28	-	-	ADJ
admet-529	149	29	fold	fold	VERB
admet-529	149	30	greater	great	ADJ
admet-529	149	31	risk	risk	NOUN
admet-529	149	32	of	of	ADP
admet-529	149	33	toxicity	toxicity	NOUN
admet-529	149	34	findings	finding	NOUN
admet-529	149	35	in	in	ADP
admet-529	149	36	preclinical	preclinical	ADJ
admet-529	149	37	toxicology	toxicology	NOUN
admet-529	149	38	studies	study	NOUN
admet-529	149	39	[	[	X
admet-529	149	40	53	53	NUM
admet-529	149	41	]	]	PUNCT
admet-529	149	42	.	.	PUNCT
admet-529	150	1	an	an	DET
admet-529	150	2	alternative	alternative	NOUN
admet-529	150	3	to	to	ADP
admet-529	150	4	using	use	VERB
admet-529	150	5	log	log	NOUN
admet-529	150	6	p	p	NOUN
admet-529	150	7	,	,	PUNCT
admet-529	150	8	which	which	PRON
admet-529	150	9	could	could	AUX
admet-529	150	10	oversimplify	oversimplify	VERB
admet-529	150	11	in	in	ADP
admet-529	150	12	vivo	vivo	ADJ
admet-529	150	13	behavior	behavior	NOUN
admet-529	150	14	of	of	ADP
admet-529	150	15	compounds	compound	NOUN
admet-529	150	16	,	,	PUNCT
admet-529	150	17	was	be	AUX
admet-529	150	18	proposed	propose	VERB
admet-529	150	19	by	by	ADP
admet-529	150	20	wenlock	wenlock	NOUN
admet-529	150	21	[	[	X
admet-529	150	22	54	54	NUM
admet-529	150	23	]	]	PUNCT
admet-529	150	24	.	.	PUNCT
admet-529	151	1	this	this	DET
admet-529	151	2	criterion	criterion	NOUN
admet-529	151	3	is	be	AUX
admet-529	151	4	based	base	VERB
admet-529	151	5	on	on	ADP
admet-529	151	6	the	the	DET
admet-529	151	7	amount	amount	NOUN
admet-529	151	8	of	of	ADP
admet-529	151	9	compound	compound	NOUN
admet-529	151	10	in	in	ADP
admet-529	151	11	the	the	DET
admet-529	151	12	body	body	NOUN
admet-529	151	13	at	at	ADP
admet-529	151	14	a	a	DET
admet-529	151	15	steady	steady	ADJ
admet-529	151	16	state	state	NOUN
admet-529	151	17	.	.	PUNCT
admet-529	152	1	the	the	DET
admet-529	152	2	relationship	relationship	NOUN
admet-529	152	3	of	of	ADP
admet-529	152	4	this	this	DET
admet-529	152	5	criterion	criterion	NOUN
admet-529	152	6	at	at	ADP
admet-529	152	7	an	an	DET
admet-529	152	8	acceptable	acceptable	ADJ
admet-529	152	9	human	human	ADJ
admet-529	152	10	dose	dose	NOUN
admet-529	152	11	of	of	ADP
admet-529	152	12	0.5	0.5	NUM
admet-529	152	13	mg/	mg/	NOUN
admet-529	152	14	kg	kg	NOUN
admet-529	152	15	for	for	ADP
admet-529	152	16	242	242	NUM
admet-529	152	17	oral	oral	ADJ
admet-529	152	18	drugs	drug	NOUN
admet-529	152	19	with	with	ADP
admet-529	152	20	different	different	ADJ
admet-529	152	21	in	in	ADP
admet-529	152	22	vivo	vivo	ADJ
admet-529	152	23	plasma	plasma	NOUN
admet-529	152	24	clearances	clearance	NOUN
admet-529	152	25	was	be	AUX
admet-529	152	26	established	establish	VERB
admet-529	152	27	with	with	ADP
admet-529	152	28	regard	regard	NOUN
admet-529	152	29	to	to	ADP
admet-529	152	30	their	their	PRON
admet-529	152	31	safety	safety	NOUN
admet-529	152	32	profiles	profile	NOUN
admet-529	152	33	.	.	PUNCT
admet-529	153	1	experimental	experimental	ADJ
admet-529	153	2	log	log	NOUN
admet-529	153	3	d	d	NOUN
admet-529	153	4	determinations	determination	VERB
admet-529	153	5	the	the	DET
admet-529	153	6	optimal	optimal	ADJ
admet-529	153	7	range	range	NOUN
admet-529	153	8	of	of	ADP
admet-529	153	9	log	log	NOUN
admet-529	153	10	d	d	NOUN
admet-529	153	11	to	to	PART
admet-529	153	12	satisfy	satisfy	VERB
admet-529	153	13	admet	admet	PROPN
admet-529	153	14	properties	property	NOUN
admet-529	153	15	centers	center	NOUN
admet-529	153	16	on	on	ADP
admet-529	153	17	2	2	NUM
admet-529	153	18	(	(	PUNCT
admet-529	153	19	+	+	NOUN
admet-529	153	20	/-1	/-1	PUNCT
admet-529	153	21	)	)	PUNCT
admet-529	154	1	[	[	X
admet-529	154	2	3	3	NUM
admet-529	154	3	]	]	PUNCT
admet-529	154	4	,	,	PUNCT
admet-529	154	5	but	but	CCONJ
admet-529	154	6	expands	expand	VERB
admet-529	154	7	far	far	ADV
admet-529	154	8	beyond	beyond	ADP
admet-529	154	9	that	that	DET
admet-529	154	10	range	range	NOUN
admet-529	154	11	for	for	ADP
admet-529	154	12	some	some	DET
admet-529	154	13	marketed	market	VERB
admet-529	154	14	drugs	drug	NOUN
admet-529	154	15	[	[	X
admet-529	154	16	36	36	NUM
admet-529	154	17	]	]	PUNCT
admet-529	154	18	.	.	PUNCT
admet-529	155	1	the	the	DET
admet-529	155	2	wide	wide	ADJ
admet-529	155	3	range	range	NOUN
admet-529	155	4	of	of	ADP
admet-529	155	5	lipophilicity	lipophilicity	NOUN
admet-529	155	6	employed	employ	VERB
admet-529	155	7	in	in	ADP
admet-529	155	8	modern	modern	ADJ
admet-529	155	9	drug	drug	NOUN
admet-529	155	10	design	design	NOUN
admet-529	155	11	requires	require	VERB
admet-529	155	12	experimental	experimental	ADJ
admet-529	155	13	methods	method	NOUN
admet-529	155	14	and	and	CCONJ
admet-529	155	15	computational	computational	ADJ
admet-529	155	16	models	model	NOUN
admet-529	155	17	to	to	PART
admet-529	155	18	support	support	VERB
admet-529	155	19	exploitation	exploitation	NOUN
admet-529	155	20	of	of	ADP
admet-529	155	21	these	these	DET
admet-529	155	22	chemical	chemical	ADJ
admet-529	155	23	spaces	space	NOUN
admet-529	155	24	.	.	PUNCT
admet-529	156	1	the	the	DET
admet-529	156	2	chromatography	chromatography	NOUN
admet-529	156	3	based	base	VERB
admet-529	156	4	elog	elog	PROPN
admet-529	156	5	d	d	PROPN
admet-529	156	6	method	method	NOUN
admet-529	156	7	[	[	X
admet-529	156	8	6	6	NUM
admet-529	156	9	,	,	PUNCT
admet-529	156	10	55	55	NUM
admet-529	156	11	]	]	PUNCT
admet-529	156	12	has	have	AUX
admet-529	156	13	been	be	AUX
admet-529	156	14	developed	develop	VERB
admet-529	156	15	at	at	ADP
admet-529	156	16	pfizer	pfizer	NOUN
admet-529	156	17	to	to	PART
admet-529	156	18	alleviate	alleviate	VERB
admet-529	156	19	limitations	limitation	NOUN
admet-529	156	20	the	the	PRON
admet-529	156	21	of	of	ADP
admet-529	156	22	the	the	DET
admet-529	156	23	classical	classical	ADJ
admet-529	156	24	shake	shake	NOUN
admet-529	156	25	-	-	PUNCT
admet-529	156	26	flask	flask	NOUN
admet-529	156	27	technique	technique	NOUN
admet-529	156	28	and	and	CCONJ
admet-529	156	29	to	to	PART
admet-529	156	30	extend	extend	VERB
admet-529	156	31	to	to	ADP
admet-529	156	32	compounds	compound	NOUN
admet-529	156	33	bro5	bro5	PROPN
admet-529	156	34	.	.	PUNCT
admet-529	157	1	since	since	SCONJ
admet-529	157	2	its	its	PRON
admet-529	157	3	introduction	introduction	NOUN
admet-529	157	4	,	,	PUNCT
admet-529	157	5	it	it	PRON
admet-529	157	6	has	have	AUX
admet-529	157	7	been	be	AUX
admet-529	157	8	used	use	VERB
admet-529	157	9	successfully	successfully	ADV
admet-529	157	10	in	in	ADP
admet-529	157	11	a	a	DET
admet-529	157	12	traditional	traditional	ADJ
admet-529	157	13	chemistry	chemistry	NOUN
admet-529	157	14	space	space	NOUN
admet-529	157	15	[	[	X
admet-529	157	16	22	22	NUM
admet-529	157	17	,	,	PUNCT
admet-529	157	18	56	56	NUM
admet-529	157	19	-	-	SYM
admet-529	157	20	60	60	NUM
admet-529	157	21	]	]	PUNCT
admet-529	157	22	as	as	ADV
admet-529	157	23	well	well	ADV
admet-529	157	24	as	as	ADP
admet-529	157	25	in	in	ADP
admet-529	157	26	the	the	DET
admet-529	157	27	bro5	bro5	NOUN
admet-529	157	28	programs	program	NOUN
admet-529	157	29	[	[	X
admet-529	157	30	38	38	NUM
admet-529	157	31	]	]	PUNCT
admet-529	157	32	.	.	PUNCT
admet-529	158	1	the	the	DET
admet-529	158	2	simultaneous	simultaneous	ADJ
admet-529	158	3	optimization	optimization	NOUN
admet-529	158	4	of	of	ADP
admet-529	158	5	potency	potency	NOUN
admet-529	158	6	and	and	CCONJ
admet-529	158	7	clearance	clearance	NOUN
admet-529	158	8	using	use	VERB
admet-529	158	9	both	both	CCONJ
admet-529	158	10	measured	measure	VERB
admet-529	158	11	and	and	CCONJ
admet-529	158	12	calculated	calculate	VERB
admet-529	158	13	elog	elog	PROPN
admet-529	158	14	d	d	X
admet-529	158	15	has	have	AUX
admet-529	158	16	been	be	AUX
admet-529	158	17	described	describe	VERB
admet-529	158	18	for	for	ADP
admet-529	158	19	the	the	DET
admet-529	158	20	takeda	takeda	NOUN
admet-529	158	21	-	-	PUNCT
admet-529	158	22	g	g	NOUN
admet-529	158	23	-	-	PUNCT
admet-529	158	24	protein	protein	NOUN
admet-529	158	25	-	-	PUNCT
admet-529	158	26	receptor-5	receptor-5	NOUN
admet-529	158	27	(	(	PUNCT
admet-529	158	28	tgr5	tgr5	PROPN
admet-529	158	29	)	)	PUNCT
admet-529	158	30	program	program	NOUN
admet-529	158	31	seeking	seek	VERB
admet-529	158	32	an	an	DET
admet-529	158	33	orally	orally	ADV
admet-529	158	34	available	available	ADJ
admet-529	158	35	compound	compound	NOUN
admet-529	158	36	for	for	ADP
admet-529	158	37	improved	improve	VERB
admet-529	158	38	glycemic	glycemic	ADJ
admet-529	158	39	control	control	NOUN
admet-529	158	40	via	via	ADP
admet-529	158	41	glucose	glucose	NOUN
admet-529	158	42	-	-	PUNCT
admet-529	158	43	dependent	dependent	ADJ
admet-529	158	44	insulin	insulin	NOUN
admet-529	158	45	secretion	secretion	NOUN
admet-529	158	46	.	.	PUNCT
admet-529	159	1	this	this	PRON
admet-529	159	2	has	have	AUX
admet-529	159	3	led	lead	VERB
admet-529	159	4	to	to	ADP
admet-529	159	5	significantly	significantly	ADV
admet-529	159	6	improved	improve	VERB
admet-529	159	7	clearance	clearance	NOUN
admet-529	159	8	(	(	PUNCT
admet-529	159	9	hlm	hlm	X
admet-529	159	10	<	<	X
admet-529	159	11	100	100	NUM
admet-529	159	12	)	)	PUNCT
admet-529	159	13	,	,	PUNCT
admet-529	159	14	log	log	VERB
admet-529	159	15	d	d	NOUN
admet-529	159	16	=	=	SYM
admet-529	159	17	2	2	NUM
admet-529	159	18	,	,	PUNCT
admet-529	159	19	and	and	CCONJ
admet-529	159	20	equivalent	equivalent	ADJ
admet-529	159	21	potency	potency	NOUN
admet-529	159	22	compared	compare	VERB
admet-529	159	23	to	to	ADP
admet-529	159	24	competitor	competitor	NOUN
admet-529	159	25	compounds	compound	NOUN
admet-529	159	26	with	with	ADP
admet-529	159	27	high	high	ADJ
admet-529	159	28	clearance	clearance	NOUN
admet-529	159	29	hlm	hlm	X
admet-529	159	30	>	>	NUM
admet-529	159	31	200	200	NUM
admet-529	159	32	and	and	CCONJ
admet-529	159	33	log	log	VERB
admet-529	160	1	d	d	X
admet-529	160	2	>	>	X
admet-529	160	3	2	2	NUM
admet-529	161	1	[	[	X
admet-529	161	2	50	50	NUM
admet-529	161	3	]	]	PUNCT
admet-529	161	4	.	.	PUNCT
admet-529	162	1	lipophilicity	lipophilicity	NOUN
admet-529	162	2	(	(	PUNCT
admet-529	162	3	elog	elog	NOUN
admet-529	162	4	d	d	PROPN
admet-529	162	5	)	)	PUNCT
admet-529	162	6	has	have	AUX
admet-529	162	7	also	also	ADV
admet-529	162	8	been	be	AUX
admet-529	162	9	utilized	utilize	VERB
admet-529	162	10	in	in	ADP
admet-529	162	11	clinical	clinical	ADJ
admet-529	162	12	studies	study	NOUN
admet-529	162	13	to	to	PART
admet-529	162	14	understand	understand	VERB
admet-529	162	15	the	the	DET
admet-529	162	16	specific	specific	ADJ
admet-529	162	17	and	and	CCONJ
admet-529	162	18	non	non	ADJ
admet-529	162	19	-	-	ADJ
admet-529	162	20	specific	specific	ADJ
admet-529	162	21	binding	binding	NOUN
admet-529	162	22	of	of	ADP
admet-529	162	23	an	an	DET
admet-529	162	24	active	active	ADJ
admet-529	162	25	ingredient	ingredient	NOUN
admet-529	162	26	to	to	ADP
admet-529	162	27	the	the	DET
admet-529	162	28	beta	beta	NOUN
admet-529	162	29	-	-	PUNCT
admet-529	162	30	amyloid	amyloid	NOUN
admet-529	162	31	plaques	plaque	NOUN
admet-529	162	32	in	in	ADP
admet-529	162	33	alzheimer	alzheimer	PROPN
admet-529	162	34	’s	’s	PART
admet-529	162	35	disease	disease	NOUN
admet-529	162	36	patients	patient	NOUN
admet-529	162	37	which	which	PRON
admet-529	162	38	has	have	AUX
admet-529	162	39	been	be	AUX
admet-529	162	40	observed	observe	VERB
admet-529	162	41	with	with	ADP
admet-529	162	42	high	high	ADJ
admet-529	162	43	contrast	contrast	NOUN
admet-529	162	44	positron	positron	NOUN
admet-529	162	45	emission	emission	NOUN
admet-529	162	46	tomography	tomography	NOUN
admet-529	162	47	(	(	PUNCT
admet-529	162	48	pet	pet	NOUN
admet-529	162	49	)	)	PUNCT
admet-529	162	50	imaging	imaging	NOUN
admet-529	163	1	[	[	X
admet-529	163	2	61	61	NUM
admet-529	163	3	]	]	PUNCT
admet-529	163	4	.	.	PUNCT
admet-529	164	1	at	at	ADP
admet-529	164	2	pfizer	pfizer	NOUN
admet-529	164	3	,	,	PUNCT
admet-529	164	4	log	log	VERB
admet-529	164	5	d	d	NOUN
admet-529	164	6	at	at	ADP
admet-529	164	7	ph	ph	PROPN
admet-529	164	8	7.4	7.4	NUM
admet-529	164	9	is	be	AUX
admet-529	164	10	routinely	routinely	ADV
admet-529	164	11	measured	measure	VERB
admet-529	164	12	for	for	ADP
admet-529	164	13	most	most	ADJ
admet-529	164	14	compounds	compound	NOUN
admet-529	164	15	using	use	VERB
admet-529	164	16	either	either	CCONJ
admet-529	164	17	sflog	sflog	PROPN
admet-529	164	18	d	d	NOUN
admet-529	164	19	or	or	CCONJ
admet-529	164	20	elog	elog	NOUN
admet-529	164	21	d	d	NOUN
admet-529	164	22	or	or	CCONJ
admet-529	164	23	both	both	DET
admet-529	164	24	methods	method	NOUN
admet-529	164	25	;	;	PUNCT
admet-529	164	26	each	each	DET
admet-529	164	27	method	method	NOUN
admet-529	164	28	has	have	VERB
admet-529	164	29	limitations	limitation	NOUN
admet-529	164	30	.	.	PUNCT
admet-529	165	1	while	while	SCONJ
admet-529	165	2	elog	elog	NOUN
admet-529	165	3	d	d	NOUN
admet-529	165	4	can	can	AUX
admet-529	165	5	not	not	PART
admet-529	165	6	be	be	AUX
admet-529	165	7	applied	apply	VERB
admet-529	165	8	to	to	ADP
admet-529	165	9	acids	acid	NOUN
admet-529	165	10	,	,	PUNCT
admet-529	165	11	sflog	sflog	PROPN
admet-529	165	12	d	d	PROPN
admet-529	165	13	has	have	VERB
admet-529	165	14	a	a	DET
admet-529	165	15	limitation	limitation	NOUN
admet-529	165	16	in	in	ADP
admet-529	165	17	measuring	measure	VERB
admet-529	165	18	values	value	NOUN
admet-529	165	19	above	above	ADP
admet-529	165	20	3.5	3.5	NUM
admet-529	165	21	due	due	ADP
admet-529	165	22	to	to	ADP
admet-529	165	23	the	the	DET
admet-529	165	24	increasing	increase	VERB
admet-529	165	25	errors	error	NOUN
admet-529	165	26	in	in	ADP
admet-529	165	27	quantification	quantification	NOUN
admet-529	165	28	of	of	ADP
admet-529	165	29	concentration	concentration	NOUN
admet-529	165	30	g.h	g.h	PROPN
admet-529	165	31	.	.	PROPN
admet-529	166	1	goetz	goetz	PROPN
admet-529	166	2	and	and	CCONJ
admet-529	166	3	m.	m.	NOUN
admet-529	166	4	shalaeva	shalaeva	PROPN
admet-529	166	5	admet	admet	PROPN
admet-529	166	6	&	&	CCONJ
admet-529	166	7	dmpk	dmpk	PROPN
admet-529	166	8	6(2	6(2	NUM
admet-529	166	9	)	)	PUNCT
admet-529	166	10	(	(	PUNCT
admet-529	166	11	2018	2018	NUM
admet-529	166	12	)	)	PUNCT
admet-529	166	13	85	85	NUM
admet-529	166	14	-	-	SYM
admet-529	166	15	104	104	NUM
admet-529	166	16	92	92	NUM
admet-529	166	17	extremes	extreme	NOUN
admet-529	166	18	(	(	PUNCT
admet-529	166	19	indeed	indeed	ADV
admet-529	166	20	,	,	PUNCT
admet-529	166	21	log	log	VERB
admet-529	166	22	d	d	NOUN
admet-529	166	23	=	=	SYM
admet-529	166	24	4	4	NUM
admet-529	166	25	implies	imply	VERB
admet-529	166	26	that	that	SCONJ
admet-529	166	27	the	the	DET
admet-529	166	28	concentration	concentration	NOUN
admet-529	166	29	in	in	ADP
admet-529	166	30	1	1	NUM
admet-529	166	31	-	-	PUNCT
admet-529	166	32	octanol	octanol	NOUN
admet-529	166	33	is	be	AUX
admet-529	166	34	10,000	10,000	NUM
admet-529	166	35	times	time	NOUN
admet-529	166	36	higher	high	ADJ
admet-529	166	37	than	than	ADP
admet-529	166	38	in	in	ADP
admet-529	166	39	the	the	DET
admet-529	166	40	aqueous	aqueous	ADJ
admet-529	166	41	phase	phase	NOUN
admet-529	166	42	)	)	PUNCT
admet-529	166	43	.	.	PUNCT
admet-529	167	1	additionally	additionally	ADV
admet-529	167	2	,	,	PUNCT
admet-529	167	3	an	an	DET
admet-529	167	4	accurate	accurate	ADJ
admet-529	167	5	prediction	prediction	NOUN
admet-529	167	6	of	of	ADP
admet-529	167	7	log	log	NOUN
admet-529	167	8	d	d	NOUN
admet-529	167	9	at	at	ADP
admet-529	167	10	ph	ph	NOUN
admet-529	167	11	=	=	SYM
admet-529	167	12	7.4	7.4	NUM
admet-529	167	13	is	be	AUX
admet-529	167	14	still	still	ADV
admet-529	167	15	an	an	DET
admet-529	167	16	issue	issue	NOUN
admet-529	167	17	for	for	ADP
admet-529	167	18	novel	novel	ADJ
admet-529	167	19	structures	structure	NOUN
admet-529	167	20	and	and	CCONJ
admet-529	167	21	therefore	therefore	ADV
admet-529	167	22	comparisons	comparison	NOUN
admet-529	167	23	of	of	ADP
admet-529	167	24	sflog	sflog	PROPN
admet-529	167	25	d	d	PROPN
admet-529	167	26	and	and	CCONJ
admet-529	167	27	elog	elog	PROPN
admet-529	167	28	d	d	PROPN
admet-529	167	29	values	value	NOUN
admet-529	167	30	are	be	AUX
admet-529	167	31	often	often	ADV
admet-529	167	32	useful	useful	ADJ
admet-529	167	33	.	.	PUNCT
admet-529	168	1	with	with	ADP
admet-529	168	2	project	project	NOUN
admet-529	168	3	x	x	X
admet-529	168	4	,	,	PUNCT
admet-529	168	5	compounds	compound	NOUN
admet-529	168	6	were	be	AUX
admet-529	168	7	evaluated	evaluate	VERB
admet-529	168	8	using	use	VERB
admet-529	168	9	sflog	sflog	PROPN
admet-529	168	10	d	d	PROPN
admet-529	168	11	(	(	PUNCT
admet-529	168	12	and	and	CCONJ
admet-529	168	13	occasionally	occasionally	ADV
admet-529	168	14	elog	elog	VERB
admet-529	168	15	d	d	PROPN
admet-529	168	16	)	)	PUNCT
admet-529	168	17	,	,	PUNCT
admet-529	168	18	but	but	CCONJ
admet-529	168	19	significant	significant	ADJ
admet-529	168	20	discrepancies	discrepancy	NOUN
admet-529	168	21	were	be	AUX
admet-529	168	22	observed	observe	VERB
admet-529	168	23	for	for	ADP
admet-529	168	24	“	"	PUNCT
admet-529	168	25	low	low	ADJ
admet-529	168	26	”	"	PUNCT
admet-529	168	27	sflog	sflog	NOUN
admet-529	168	28	d	d	PROPN
admet-529	168	29	samples	sample	NOUN
admet-529	168	30	(	(	PUNCT
admet-529	168	31	figure	figure	NOUN
admet-529	168	32	5	5	NUM
admet-529	168	33	.	.	PUNCT
admet-529	169	1	(	(	PUNCT
admet-529	169	2	a	a	NOUN
admet-529	169	3	)	)	PUNCT
admet-529	169	4	)	)	PUNCT
admet-529	169	5	.	.	PUNCT
admet-529	170	1	however	however	ADV
admet-529	170	2	,	,	PUNCT
admet-529	170	3	if	if	SCONJ
admet-529	170	4	elog	elog	PROPN
admet-529	170	5	d	d	PROPN
admet-529	170	6	–	–	PUNCT
admet-529	170	7	sflog	sflog	PROPN
admet-529	171	1	d	d	X
admet-529	171	2	differences	difference	NOUN
admet-529	171	3	(	(	PUNCT
admet-529	171	4	residuals	residual	NOUN
admet-529	171	5	)	)	PUNCT
admet-529	171	6	were	be	AUX
admet-529	171	7	plotted	plot	VERB
admet-529	171	8	against	against	ADP
admet-529	171	9	elog	elog	NOUN
admet-529	171	10	d	d	NOUN
admet-529	171	11	it	it	PRON
admet-529	171	12	became	become	VERB
admet-529	171	13	apparent	apparent	ADJ
admet-529	171	14	that	that	SCONJ
admet-529	171	15	the	the	DET
admet-529	171	16	largest	large	ADJ
admet-529	171	17	discrepancies	discrepancy	NOUN
admet-529	171	18	were	be	AUX
admet-529	171	19	in	in	ADP
admet-529	171	20	the	the	DET
admet-529	171	21	range	range	NOUN
admet-529	171	22	above	above	ADP
admet-529	171	23	3.0	3.0	NUM
admet-529	171	24	.	.	PUNCT
admet-529	172	1	(	(	PUNCT
admet-529	172	2	figure	figure	NOUN
admet-529	172	3	5(b	5(b	NUM
admet-529	172	4	)	)	PUNCT
admet-529	172	5	)	)	PUNCT
admet-529	172	6	.	.	PUNCT
admet-529	173	1	this	this	PRON
admet-529	173	2	illustrates	illustrate	VERB
admet-529	173	3	how	how	SCONJ
admet-529	173	4	the	the	DET
admet-529	173	5	sflog	sflog	NOUN
admet-529	173	6	d	d	PRON
admet-529	173	7	procedure	procedure	NOUN
admet-529	173	8	may	may	AUX
admet-529	173	9	underestimate	underestimate	VERB
admet-529	173	10	lipophilicity	lipophilicity	NOUN
admet-529	173	11	values	value	NOUN
admet-529	173	12	above	above	ADP
admet-529	173	13	3	3	NUM
admet-529	173	14	.	.	PUNCT
admet-529	173	15	figure	figure	NOUN
admet-529	173	16	5	5	NUM
admet-529	173	17	.	.	PUNCT
admet-529	174	1	(	(	PUNCT
admet-529	174	2	a	a	X
admet-529	174	3	)	)	PUNCT
admet-529	174	4	comparison	comparison	NOUN
admet-529	174	5	of	of	ADP
admet-529	174	6	sflog	sflog	PROPN
admet-529	174	7	d	d	PROPN
admet-529	174	8	and	and	CCONJ
admet-529	174	9	elog	elog	PROPN
admet-529	174	10	d	d	PROPN
admet-529	174	11	values	value	NOUN
admet-529	174	12	for	for	ADP
admet-529	174	13	project	project	NOUN
admet-529	174	14	x	x	X
admet-529	174	15	;	;	PUNCT
admet-529	174	16	(	(	PUNCT
admet-529	174	17	b	b	X
admet-529	174	18	)	)	PUNCT
admet-529	174	19	sflog	sflog	PROPN
admet-529	174	20	d	d	PROPN
admet-529	174	21	elog	elog	NOUN
admet-529	174	22	d	d	NOUN
admet-529	174	23	residuals	residual	NOUN
admet-529	174	24	vs.	vs.	ADP
admet-529	174	25	elog	elog	NOUN
admet-529	174	26	d	d	PROPN
admet-529	174	27	in	in	ADP
admet-529	174	28	summary	summary	NOUN
admet-529	174	29	,	,	PUNCT
admet-529	174	30	if	if	SCONJ
admet-529	174	31	analyzed	analyze	VERB
admet-529	174	32	by	by	ADP
admet-529	174	33	elog	elog	PROPN
admet-529	174	34	d	d	PROPN
admet-529	174	35	,	,	PUNCT
admet-529	174	36	both	both	PRON
admet-529	174	37	sflog	sflog	PROPN
admet-529	174	38	d	d	NOUN
admet-529	174	39	and	and	CCONJ
admet-529	174	40	elog	elog	PROPN
admet-529	174	41	d	d	AUX
admet-529	174	42	give	give	VERB
admet-529	174	43	,	,	PUNCT
admet-529	174	44	as	as	SCONJ
admet-529	174	45	expected	expect	VERB
admet-529	174	46	,	,	PUNCT
admet-529	174	47	very	very	ADV
admet-529	174	48	similar	similar	ADJ
admet-529	174	49	values	value	NOUN
admet-529	174	50	(	(	PUNCT
admet-529	174	51	within	within	ADP
admet-529	174	52	+0.5	+0.5	NUM
admet-529	174	53	)	)	PUNCT
admet-529	174	54	in	in	ADP
admet-529	174	55	the	the	DET
admet-529	174	56	elog	elog	NOUN
admet-529	175	1	d	d	X
admet-529	175	2	<	<	X
admet-529	175	3	3	3	NUM
admet-529	175	4	range	range	NOUN
admet-529	175	5	.	.	PUNCT
admet-529	176	1	however	however	ADV
admet-529	176	2	,	,	PUNCT
admet-529	176	3	in	in	ADP
admet-529	176	4	the	the	DET
admet-529	176	5	elog	elog	NOUN
admet-529	176	6	d	d	X
admet-529	176	7	>	>	X
admet-529	176	8	3	3	NUM
admet-529	176	9	range	range	NOUN
admet-529	176	10	,	,	PUNCT
admet-529	176	11	many	many	ADJ
admet-529	176	12	sflog	sflog	NOUN
admet-529	176	13	d	d	PROPN
admet-529	176	14	values	value	NOUN
admet-529	176	15	are	be	AUX
admet-529	176	16	under	under	ADV
admet-529	176	17	-	-	PUNCT
admet-529	176	18	evaluated	evaluate	VERB
admet-529	176	19	(	(	PUNCT
admet-529	176	20	by	by	ADP
admet-529	176	21	up	up	ADP
admet-529	176	22	to	to	PART
admet-529	176	23	2	2	NUM
admet-529	176	24	log	log	NOUN
admet-529	176	25	units	unit	NOUN
admet-529	176	26	)	)	PUNCT
admet-529	176	27	.	.	PUNCT
admet-529	177	1	therefore	therefore	ADV
admet-529	177	2	,	,	PUNCT
admet-529	177	3	it	it	PRON
admet-529	177	4	is	be	AUX
admet-529	177	5	important	important	ADJ
admet-529	177	6	to	to	PART
admet-529	177	7	recognize	recognize	VERB
admet-529	177	8	and	and	CCONJ
admet-529	177	9	respect	respect	VERB
admet-529	177	10	the	the	DET
admet-529	177	11	experimental	experimental	ADJ
admet-529	177	12	methods	method	NOUN
admet-529	177	13	applicability	applicability	NOUN
admet-529	177	14	domain	domain	NOUN
admet-529	177	15	when	when	SCONJ
admet-529	177	16	using	use	VERB
admet-529	177	17	log	log	NOUN
admet-529	177	18	d	d	PROPN
admet-529	177	19	for	for	ADP
admet-529	177	20	sar	sar	NOUN
admet-529	177	21	or	or	CCONJ
admet-529	177	22	building	build	VERB
admet-529	177	23	computational	computational	ADJ
admet-529	177	24	models	model	NOUN
admet-529	177	25	based	base	VERB
admet-529	177	26	on	on	ADP
admet-529	177	27	such	such	ADJ
admet-529	177	28	data	datum	NOUN
admet-529	177	29	.	.	PUNCT
admet-529	178	1	computed	compute	VERB
admet-529	178	2	log	log	NOUN
admet-529	178	3	d	d	NOUN
admet-529	178	4	day	day	NOUN
admet-529	178	5	-	-	PUNCT
admet-529	178	6	to	to	ADP
admet-529	178	7	-	-	PUNCT
admet-529	178	8	day	day	NOUN
admet-529	178	9	experience	experience	NOUN
admet-529	178	10	in	in	ADP
admet-529	178	11	measuring	measure	VERB
admet-529	178	12	log	log	NOUN
admet-529	178	13	d	d	NUM
admet-529	178	14	demonstrated	demonstrate	VERB
admet-529	178	15	that	that	SCONJ
admet-529	178	16	despite	despite	SCONJ
admet-529	178	17	great	great	ADJ
admet-529	178	18	efforts	effort	NOUN
admet-529	178	19	to	to	PART
admet-529	178	20	improve	improve	VERB
admet-529	178	21	log	log	NOUN
admet-529	178	22	d	d	NOUN
admet-529	178	23	calculations	calculation	NOUN
admet-529	178	24	,	,	PUNCT
admet-529	178	25	there	there	PRON
admet-529	178	26	were	be	VERB
admet-529	178	27	still	still	ADV
admet-529	178	28	instances	instance	NOUN
admet-529	178	29	where	where	SCONJ
admet-529	178	30	log	log	NOUN
admet-529	178	31	d	d	NOUN
admet-529	178	32	predictions	prediction	NOUN
admet-529	178	33	are	be	AUX
admet-529	178	34	inaccurate	inaccurate	ADJ
admet-529	178	35	;	;	PUNCT
admet-529	178	36	especially	especially	ADV
admet-529	178	37	if	if	SCONJ
admet-529	178	38	ionization	ionization	NOUN
admet-529	178	39	is	be	AUX
admet-529	178	40	involved	involve	VERB
admet-529	178	41	and	and	CCONJ
admet-529	178	42	an	an	DET
admet-529	178	43	accurate	accurate	ADJ
admet-529	178	44	pka	pka	PROPN
admet-529	178	45	is	be	AUX
admet-529	178	46	needed	need	VERB
admet-529	178	47	to	to	PART
admet-529	178	48	adjust	adjust	VERB
admet-529	178	49	the	the	DET
admet-529	178	50	calculated	calculate	VERB
admet-529	178	51	log	log	NOUN
admet-529	178	52	p	p	NOUN
admet-529	178	53	of	of	ADP
admet-529	178	54	a	a	DET
admet-529	178	55	neutral	neutral	ADJ
admet-529	178	56	form	form	NOUN
admet-529	178	57	to	to	ADP
admet-529	178	58	a	a	DET
admet-529	178	59	log	log	NOUN
admet-529	178	60	d	d	NOUN
admet-529	178	61	at	at	ADP
admet-529	178	62	a	a	DET
admet-529	178	63	particular	particular	ADJ
admet-529	178	64	ph	ph	NOUN
admet-529	178	65	,	,	PUNCT
admet-529	178	66	usually	usually	ADV
admet-529	178	67	7.4	7.4	NUM
admet-529	178	68	.	.	PUNCT
admet-529	179	1	the	the	DET
admet-529	179	2	cpflogd	cpflogd	ADJ
admet-529	179	3	model	model	NOUN
admet-529	179	4	built	build	VERB
admet-529	179	5	at	at	ADP
admet-529	179	6	pfizer	pfizer	NOUN
admet-529	179	7	takes	take	VERB
admet-529	179	8	into	into	ADP
admet-529	179	9	account	account	NOUN
admet-529	179	10	both	both	DET
admet-529	179	11	sflog	sflog	PROPN
admet-529	179	12	d	d	NOUN
admet-529	179	13	and	and	CCONJ
admet-529	179	14	elog	elog	PROPN
admet-529	179	15	d	d	X
admet-529	179	16	experimental	experimental	ADJ
admet-529	179	17	values	value	NOUN
admet-529	179	18	while	while	SCONJ
admet-529	179	19	respecting	respect	VERB
admet-529	179	20	the	the	DET
admet-529	179	21	limits	limit	NOUN
admet-529	179	22	of	of	ADP
admet-529	179	23	each	each	DET
admet-529	179	24	method	method	NOUN
admet-529	179	25	,	,	PUNCT
admet-529	179	26	i.e.	i.e.	X
admet-529	179	27	sflog	sflog	PROPN
admet-529	179	28	d	d	X
admet-529	179	29	<	<	X
admet-529	179	30	3	3	NUM
admet-529	179	31	and	and	CCONJ
admet-529	179	32	elog	elog	NOUN
admet-529	179	33	d	d	PROPN
admet-529	179	34	for	for	ADP
admet-529	179	35	bases	basis	NOUN
admet-529	179	36	and	and	CCONJ
admet-529	179	37	neutrals	neutral	NOUN
admet-529	179	38	only	only	ADV
admet-529	179	39	.	.	PUNCT
admet-529	180	1	consequently	consequently	ADV
admet-529	180	2	,	,	PUNCT
admet-529	180	3	the	the	DET
admet-529	180	4	model	model	NOUN
admet-529	180	5	gives	give	VERB
admet-529	180	6	preference	preference	NOUN
admet-529	180	7	to	to	PART
admet-529	180	8	sflog	sflog	VERB
admet-529	180	9	d	d	PROPN
admet-529	180	10	values	value	NOUN
admet-529	180	11	in	in	ADP
admet-529	180	12	the	the	DET
admet-529	180	13	log	log	NOUN
admet-529	181	1	d	d	NOUN
admet-529	181	2	range	range	NOUN
admet-529	181	3	below	below	ADP
admet-529	181	4	3	3	NUM
admet-529	181	5	and	and	CCONJ
admet-529	181	6	to	to	PART
admet-529	181	7	elog	elog	VERB
admet-529	181	8	d	d	NOUN
admet-529	181	9	values	value	NOUN
admet-529	181	10	in	in	ADP
admet-529	181	11	the	the	DET
admet-529	181	12	log	log	NOUN
admet-529	181	13	d	d	NOUN
admet-529	181	14	range	range	NOUN
admet-529	181	15	above	above	ADP
admet-529	181	16	3	3	NUM
admet-529	181	17	.	.	PUNCT
admet-529	182	1	the	the	DET
admet-529	182	2	cpflogd	cpflogd	ADJ
admet-529	182	3	model	model	NOUN
admet-529	182	4	is	be	AUX
admet-529	182	5	built	build	VERB
admet-529	182	6	using	use	VERB
admet-529	182	7	the	the	DET
admet-529	182	8	cubist	cubist	ADJ
admet-529	182	9	non	non	ADJ
admet-529	182	10	-	-	ADJ
admet-529	182	11	linear	linear	ADJ
admet-529	182	12	in	in	ADP
admet-529	182	13	-	-	PUNCT
admet-529	182	14	silico	silico	NOUN
admet-529	182	15	regression	regression	NOUN
admet-529	182	16	methodology	methodology	NOUN
admet-529	182	17	and	and	CCONJ
admet-529	182	18	it	it	PRON
admet-529	182	19	is	be	AUX
admet-529	182	20	regularly	regularly	ADV
admet-529	182	21	updated	update	VERB
admet-529	182	22	with	with	ADP
admet-529	182	23	the	the	DET
admet-529	182	24	latest	late	ADJ
admet-529	182	25	experimental	experimental	ADJ
admet-529	182	26	data	datum	NOUN
admet-529	182	27	,	,	PUNCT
admet-529	182	28	thus	thus	ADV
admet-529	182	29	providing	provide	VERB
admet-529	182	30	improved	improved	ADJ
admet-529	182	31	cpflogd	cpflogd	ADJ
admet-529	182	32	predictions	prediction	NOUN
admet-529	182	33	for	for	ADP
admet-529	182	34	the	the	DET
admet-529	182	35	next	next	ADJ
admet-529	182	36	design	design	NOUN
admet-529	182	37	cycle	cycle	NOUN
admet-529	182	38	.	.	PUNCT
admet-529	183	1	performance	performance	NOUN
admet-529	183	2	of	of	ADP
admet-529	183	3	the	the	DET
admet-529	183	4	cpflogd	cpflogd	NOUN
admet-529	183	5	model	model	NOUN
admet-529	183	6	is	be	AUX
admet-529	183	7	demonstrated	demonstrate	VERB
admet-529	183	8	in	in	ADP
admet-529	183	9	figure	figure	NOUN
admet-529	183	10	6	6	NUM
admet-529	183	11	on	on	ADP
admet-529	183	12	a	a	DET
admet-529	183	13	rather	rather	ADV
admet-529	183	14	challenging	challenging	ADJ
admet-529	183	15	subset	subset	NOUN
admet-529	183	16	of	of	ADP
admet-529	183	17	diverse	diverse	ADJ
admet-529	183	18	“	"	PUNCT
admet-529	183	19	natural	natural	ADJ
admet-529	183	20	-	-	PUNCT
admet-529	183	21	product	product	NOUN
admet-529	183	22	”	"	PUNCT
admet-529	183	23	like	like	ADP
admet-529	183	24	compounds	compound	NOUN
admet-529	183	25	.	.	PUNCT
admet-529	184	1	this	this	DET
admet-529	184	2	subset	subset	NOUN
admet-529	184	3	of	of	ADP
admet-529	184	4	about	about	ADV
admet-529	184	5	300	300	NUM
admet-529	184	6	molecules	molecule	NOUN
admet-529	184	7	is	be	AUX
admet-529	184	8	more	more	ADV
admet-529	184	9	complicated	complicated	ADJ
admet-529	184	10	than	than	SCONJ
admet-529	184	11	encountered	encounter	VERB
admet-529	184	12	in	in	ADP
admet-529	184	13	most	most	ADJ
admet-529	184	14	small	small	ADJ
admet-529	184	15	molecule	molecule	NOUN
admet-529	184	16	projects	project	NOUN
admet-529	184	17	.	.	PUNCT
admet-529	185	1	it	it	PRON
admet-529	185	2	encompasses	encompass	VERB
admet-529	185	3	mw	mw	NUM
admet-529	185	4	from	from	ADP
admet-529	185	5	200	200	NUM
admet-529	185	6	to	to	ADP
admet-529	185	7	2000	2000	NUM
admet-529	185	8	,	,	PUNCT
admet-529	185	9	has	have	VERB
admet-529	185	10	compounds	compound	NOUN
admet-529	185	11	violating	violate	VERB
admet-529	185	12	up	up	ADP
admet-529	185	13	to	to	PART
admet-529	185	14	four	four	NUM
admet-529	185	15	ro5	ro5	ADJ
admet-529	185	16	,	,	PUNCT
admet-529	185	17	with	with	ADP
admet-529	185	18	high	high	ADJ
admet-529	185	19	nrotb	nrotb	PROPN
admet-529	185	20	,	,	PUNCT
admet-529	185	21	hbd	hbd	NOUN
admet-529	185	22	and	and	CCONJ
admet-529	185	23	hba	hba	NOUN
admet-529	185	24	.	.	PUNCT
admet-529	186	1	for	for	ADP
admet-529	186	2	many	many	ADJ
admet-529	186	3	compounds	compound	NOUN
admet-529	186	4	in	in	ADP
admet-529	186	5	the	the	DET
admet-529	186	6	log	log	NOUN
admet-529	187	1	d	d	X
admet-529	187	2	>	>	SYM
admet-529	187	3	4	4	NUM
admet-529	187	4	range	range	NOUN
admet-529	187	5	a	a	DET
admet-529	187	6	sflog	sflog	NOUN
admet-529	187	7	d	d	NOUN
admet-529	187	8	value	value	NOUN
admet-529	187	9	could	could	AUX
admet-529	187	10	not	not	PART
admet-529	187	11	be	be	AUX
admet-529	187	12	acquired	acquire	VERB
admet-529	187	13	due	due	ADJ
admet-529	187	14	to	to	ADP
admet-529	187	15	extremely	extremely	ADV
admet-529	187	16	low	low	ADJ
admet-529	187	17	concentration	concentration	NOUN
admet-529	187	18	in	in	ADP
admet-529	187	19	the	the	DET
admet-529	187	20	aqueous	aqueous	ADJ
admet-529	187	21	phase	phase	NOUN
admet-529	187	22	and	and	CCONJ
admet-529	187	23	therefore	therefore	ADV
admet-529	187	24	elog	elog	PROPN
admet-529	187	25	d	d	PROPN
admet-529	187	26	values	value	NOUN
admet-529	187	27	were	be	AUX
admet-529	187	28	measured	measure	VERB
admet-529	187	29	on	on	ADP
admet-529	187	30	all	all	DET
admet-529	187	31	compounds	compound	NOUN
admet-529	187	32	,	,	PUNCT
admet-529	187	33	excluding	exclude	VERB
admet-529	187	34	acids	acid	NOUN
admet-529	187	35	.	.	PUNCT
admet-529	188	1	admet	admet	PROPN
admet-529	188	2	&	&	CCONJ
admet-529	188	3	dmpk	dmpk	PROPN
admet-529	188	4	6(2	6(2	NUM
admet-529	188	5	)	)	PUNCT
admet-529	188	6	(	(	PUNCT
admet-529	188	7	2018	2018	NUM
admet-529	188	8	)	)	PUNCT
admet-529	188	9	85	85	NUM
admet-529	188	10	-	-	SYM
admet-529	188	11	104	104	NUM
admet-529	188	12	leveraging	leverage	VERB
admet-529	188	13	chromatography	chromatography	NOUN
admet-529	188	14	physchem	physchem	NOUN
admet-529	188	15	properties	property	NOUN
admet-529	188	16	in	in	ADP
admet-529	188	17	drug	drug	NOUN
admet-529	188	18	design	design	NOUN
admet-529	188	19	doi	doi	NOUN
admet-529	188	20	:	:	PUNCT
admet-529	188	21	10.5599	10.5599	NUM
admet-529	188	22	/	/	SYM
admet-529	188	23	admet.529	admet.529	NOUN
admet-529	188	24	93	93	NUM
admet-529	188	25	figure	figure	NOUN
admet-529	188	26	6	6	NUM
admet-529	188	27	.	.	PUNCT
admet-529	189	1	(	(	PUNCT
admet-529	189	2	a	a	X
admet-529	189	3	)	)	PUNCT
admet-529	189	4	measured	measured	ADJ
admet-529	189	5	elog	elog	NOUN
admet-529	189	6	d	d	PROPN
admet-529	189	7	vs.	vs.	ADP
admet-529	189	8	cpflogd	cpflogd	NOUN
admet-529	189	9	;	;	PUNCT
admet-529	189	10	(	(	PUNCT
admet-529	189	11	b	b	X
admet-529	189	12	)	)	PUNCT
admet-529	189	13	measured	measure	VERB
admet-529	189	14	sflog	sflog	PROPN
admet-529	189	15	d	d	PROPN
admet-529	189	16	values	value	NOUN
admet-529	189	17	vs.	vs.	ADP
admet-529	189	18	cpflogd	cpflogd	NOUN
admet-529	189	19	.	.	PUNCT
admet-529	190	1	a	a	DET
admet-529	190	2	diverse	diverse	ADJ
admet-529	190	3	subset	subset	NOUN
admet-529	190	4	of	of	ADP
admet-529	190	5	“	"	PUNCT
admet-529	190	6	natural	natural	ADJ
admet-529	190	7	product”-like	product”-like	NOUN
admet-529	190	8	library	library	NOUN
admet-529	190	9	,	,	PUNCT
admet-529	190	10	about	about	ADV
admet-529	190	11	300	300	NUM
admet-529	190	12	compounds	compound	NOUN
admet-529	190	13	.	.	PUNCT
admet-529	191	1	the	the	DET
admet-529	191	2	size	size	NOUN
admet-529	191	3	of	of	ADP
admet-529	191	4	the	the	DET
admet-529	191	5	markers	marker	NOUN
admet-529	191	6	represents	represent	VERB
admet-529	191	7	molecular	molecular	ADJ
admet-529	191	8	weight	weight	NOUN
admet-529	191	9	(	(	PUNCT
admet-529	191	10	193	193	NUM
admet-529	191	11	to	to	PART
admet-529	191	12	2013	2013	NUM
admet-529	191	13	da	da	NOUN
admet-529	191	14	)	)	PUNCT
admet-529	191	15	.	.	PUNCT
admet-529	192	1	the	the	DET
admet-529	192	2	colours	colour	NOUN
admet-529	192	3	represent	represent	VERB
admet-529	192	4	violations	violation	NOUN
admet-529	192	5	of	of	ADP
admet-529	192	6	the	the	DET
admet-529	192	7	ro5	ro5	PROPN
admet-529	192	8	.	.	PROPN
admet-529	193	1	as	as	SCONJ
admet-529	193	2	expected	expect	VERB
admet-529	193	3	,	,	PUNCT
admet-529	193	4	cpflogd	cpflogd	PROPN
admet-529	193	5	predicted	predict	VERB
admet-529	193	6	sflog	sflog	PROPN
admet-529	193	7	d	d	X
admet-529	193	8	more	more	ADV
admet-529	193	9	accurately	accurately	ADV
admet-529	193	10	in	in	ADP
admet-529	193	11	the	the	DET
admet-529	193	12	<	<	X
admet-529	193	13	2	2	NUM
admet-529	193	14	range	range	NOUN
admet-529	193	15	and	and	CCONJ
admet-529	193	16	,	,	PUNCT
admet-529	193	17	elog	elog	NOUN
admet-529	193	18	d	d	X
admet-529	193	19	more	more	ADV
admet-529	193	20	accurately	accurately	ADV
admet-529	193	21	in	in	ADP
admet-529	193	22	the	the	DET
admet-529	193	23	>	>	SYM
admet-529	193	24	2	2	NUM
admet-529	193	25	range	range	NOUN
admet-529	193	26	.	.	PUNCT
admet-529	194	1	several	several	ADJ
admet-529	194	2	outliers	outlier	NOUN
admet-529	194	3	in	in	ADP
admet-529	194	4	the	the	DET
admet-529	194	5	upper	upper	ADJ
admet-529	194	6	left	left	ADJ
admet-529	194	7	corner	corner	NOUN
admet-529	194	8	of	of	ADP
admet-529	194	9	the	the	DET
admet-529	194	10	elog	elog	NOUN
admet-529	194	11	d	d	PROPN
admet-529	194	12	vs.	vs.	ADP
admet-529	194	13	cpflogd	cpflogd	ADJ
admet-529	194	14	figure	figure	NOUN
admet-529	194	15	6(a	6(a	NUM
admet-529	194	16	)	)	PUNCT
admet-529	194	17	represent	represent	VERB
admet-529	194	18	the	the	DET
admet-529	194	19	underestimated	underestimate	VERB
admet-529	194	20	sflogd	sflogd	NOUN
admet-529	194	21	results	result	NOUN
admet-529	194	22	used	use	VERB
admet-529	194	23	by	by	ADP
admet-529	194	24	the	the	DET
admet-529	194	25	cpflogd	cpflogd	ADJ
admet-529	194	26	model	model	NOUN
admet-529	194	27	leading	lead	VERB
admet-529	194	28	to	to	ADP
admet-529	194	29	underestimated	underestimated	ADJ
admet-529	194	30	prediction	prediction	NOUN
admet-529	194	31	values	value	NOUN
admet-529	194	32	.	.	PUNCT
admet-529	195	1	comparison	comparison	NOUN
admet-529	195	2	of	of	ADP
admet-529	195	3	cpflogd	cpflogd	NOUN
admet-529	195	4	to	to	ADP
admet-529	195	5	commercially	commercially	ADV
admet-529	195	6	available	available	ADJ
admet-529	195	7	acdlabs	acdlab	NOUN
admet-529	195	8	log	log	VERB
admet-529	195	9	d7.4	d7.4	NOUN
admet-529	195	10	predictions	prediction	NOUN
admet-529	195	11	for	for	ADP
admet-529	195	12	the	the	DET
admet-529	195	13	same	same	ADJ
admet-529	195	14	subset	subset	NOUN
admet-529	195	15	are	be	AUX
admet-529	195	16	shown	show	VERB
admet-529	195	17	in	in	ADP
admet-529	195	18	figure	figure	NOUN
admet-529	195	19	7	7	NUM
admet-529	195	20	,	,	PUNCT
admet-529	195	21	where	where	SCONJ
admet-529	195	22	many	many	ADJ
admet-529	195	23	compounds	compound	NOUN
admet-529	195	24	violating	violate	VERB
admet-529	195	25	three	three	NUM
admet-529	195	26	ro5	ro5	ADJ
admet-529	195	27	criteria	criterion	NOUN
admet-529	195	28	(	(	PUNCT
admet-529	195	29	yellow	yellow	ADJ
admet-529	195	30	markers	marker	NOUN
admet-529	195	31	)	)	PUNCT
admet-529	195	32	fell	fall	VERB
admet-529	195	33	far	far	ADV
admet-529	195	34	outside	outside	ADP
admet-529	195	35	cpflogd	cpflogd	NOUN
admet-529	195	36	,	,	PUNCT
admet-529	195	37	especially	especially	ADV
admet-529	195	38	in	in	ADP
admet-529	195	39	the	the	DET
admet-529	195	40	low	low	ADJ
admet-529	195	41	lipophilicity	lipophilicity	NOUN
admet-529	195	42	range	range	NOUN
admet-529	195	43	.	.	PUNCT
admet-529	196	1	figure	figure	NOUN
admet-529	196	2	7	7	NUM
admet-529	196	3	.	.	PUNCT
admet-529	196	4	lipophilicity	lipophilicity	NOUN
admet-529	196	5	calculations	calculation	NOUN
admet-529	196	6	using	use	VERB
admet-529	196	7	log	log	NOUN
admet-529	196	8	d7.4	d7.4	VERB
admet-529	196	9	by	by	ADP
admet-529	196	10	acd	acd	NOUN
admet-529	196	11	labs	lab	NOUN
admet-529	196	12	vs.	vs.	CCONJ
admet-529	196	13	cpflogd	cpflogd	NOUN
admet-529	196	14	for	for	ADP
admet-529	196	15	a	a	DET
admet-529	196	16	subset	subset	NOUN
admet-529	196	17	of	of	ADP
admet-529	196	18	a	a	DET
admet-529	196	19	“	"	PUNCT
admet-529	196	20	natural	natural	ADJ
admet-529	196	21	product”like	product”like	NOUN
admet-529	196	22	library	library	NOUN
admet-529	196	23	.	.	PUNCT
admet-529	197	1	it	it	PRON
admet-529	197	2	should	should	AUX
admet-529	197	3	be	be	AUX
admet-529	197	4	emphasized	emphasize	VERB
admet-529	197	5	that	that	SCONJ
admet-529	197	6	project	project	NOUN
admet-529	197	7	teams	team	NOUN
admet-529	197	8	usually	usually	ADV
admet-529	197	9	design	design	VERB
admet-529	197	10	around	around	ADP
admet-529	197	11	an	an	DET
admet-529	197	12	active	active	ADJ
admet-529	197	13	lead	lead	NOUN
admet-529	197	14	molecule	molecule	NOUN
admet-529	197	15	and	and	CCONJ
admet-529	197	16	work	work	NOUN
admet-529	197	17	on	on	ADP
admet-529	197	18	a	a	DET
admet-529	197	19	few	few	ADJ
admet-529	197	20	series	series	NOUN
admet-529	197	21	,	,	PUNCT
admet-529	197	22	where	where	SCONJ
admet-529	197	23	“	"	PUNCT
admet-529	197	24	diversity	diversity	NOUN
admet-529	197	25	”	"	PUNCT
admet-529	197	26	in	in	ADP
admet-529	197	27	a	a	DET
admet-529	197	28	general	general	ADJ
admet-529	197	29	chemistry	chemistry	NOUN
admet-529	197	30	sense	sense	NOUN
admet-529	197	31	is	be	AUX
admet-529	197	32	rather	rather	ADV
admet-529	197	33	limited	limited	ADJ
admet-529	197	34	.	.	PUNCT
admet-529	198	1	therefore	therefore	ADV
admet-529	198	2	,	,	PUNCT
admet-529	198	3	measured	measure	VERB
admet-529	198	4	log	log	NOUN
admet-529	198	5	d	d	NOUN
admet-529	198	6	values	value	NOUN
admet-529	198	7	determined	determine	VERB
admet-529	198	8	on	on	ADP
admet-529	198	9	a	a	DET
admet-529	198	10	few	few	ADJ
admet-529	198	11	compounds	compound	NOUN
admet-529	198	12	in	in	ADP
admet-529	198	13	a	a	DET
admet-529	198	14	series	series	NOUN
admet-529	198	15	introduced	introduce	VERB
admet-529	198	16	into	into	ADP
admet-529	198	17	the	the	DET
admet-529	198	18	model	model	NOUN
admet-529	198	19	often	often	ADV
admet-529	198	20	allow	allow	VERB
admet-529	198	21	significant	significant	ADJ
admet-529	198	22	improvement	improvement	NOUN
admet-529	198	23	in	in	ADP
admet-529	198	24	accuracy	accuracy	NOUN
admet-529	198	25	of	of	ADP
admet-529	198	26	cpflogd	cpflogd	ADJ
admet-529	198	27	predictions	prediction	NOUN
admet-529	198	28	in	in	ADP
admet-529	198	29	that	that	DET
admet-529	198	30	chemical	chemical	NOUN
admet-529	198	31	space	space	NOUN
admet-529	198	32	.	.	PUNCT
admet-529	199	1	polarity	polarity	NOUN
admet-529	199	2	in	in	ADP
admet-529	199	3	the	the	DET
admet-529	199	4	otherwise	otherwise	ADV
admet-529	199	5	comprehensive	comprehensive	ADJ
admet-529	199	6	iupac	iupac	PROPN
admet-529	199	7	compendium	compendium	NOUN
admet-529	199	8	of	of	ADP
admet-529	199	9	chemical	chemical	NOUN
admet-529	199	10	terminology	terminology	NOUN
admet-529	199	11	,	,	PUNCT
admet-529	199	12	also	also	ADV
admet-529	199	13	known	know	VERB
admet-529	199	14	as	as	ADP
admet-529	199	15	the	the	DET
admet-529	199	16	gold	gold	NOUN
admet-529	199	17	book	book	NOUN
admet-529	199	18	,	,	PUNCT
admet-529	199	19	(	(	PUNCT
admet-529	199	20	unlike	unlike	ADP
admet-529	199	21	lipophilicity	lipophilicity	NOUN
admet-529	199	22	,	,	PUNCT
admet-529	199	23	hydrophobicity	hydrophobicity	NOUN
admet-529	199	24	and	and	CCONJ
admet-529	199	25	hydrophilicity	hydrophilicity	NOUN
admet-529	199	26	)	)	PUNCT
admet-529	199	27	,	,	PUNCT
admet-529	199	28	the	the	DET
admet-529	199	29	compound	compound	NOUN
admet-529	199	30	polarity	polarity	NOUN
admet-529	199	31	is	be	AUX
admet-529	199	32	not	not	PART
admet-529	199	33	defined	define	VERB
admet-529	199	34	[	[	PUNCT
admet-529	199	35	2	2	NUM
admet-529	199	36	]	]	PUNCT
admet-529	199	37	.	.	PUNCT
admet-529	200	1	the	the	DET
admet-529	200	2	only	only	ADJ
admet-529	200	3	reference	reference	NOUN
admet-529	200	4	to	to	ADP
admet-529	200	5	polarity	polarity	NOUN
admet-529	200	6	in	in	ADP
admet-529	200	7	the	the	DET
admet-529	200	8	gold	gold	NOUN
admet-529	200	9	book	book	NOUN
admet-529	200	10	is	be	AUX
admet-529	200	11	coupled	couple	VERB
admet-529	200	12	with	with	ADP
admet-529	200	13	the	the	DET
admet-529	200	14	concept	concept	NOUN
admet-529	200	15	of	of	ADP
admet-529	200	16	solvent	solvent	NOUN
admet-529	200	17	rather	rather	ADV
admet-529	200	18	than	than	ADP
admet-529	200	19	solute	solute	VERB
admet-529	200	20	(	(	PUNCT
admet-529	200	21	see	see	VERB
admet-529	200	22	below	below	ADV
admet-529	200	23	)	)	PUNCT
admet-529	200	24	.	.	PUNCT
admet-529	201	1	g.h	g.h	PROPN
admet-529	201	2	.	.	PROPN
admet-529	202	1	goetz	goetz	PROPN
admet-529	202	2	and	and	CCONJ
admet-529	202	3	m.	m.	NOUN
admet-529	202	4	shalaeva	shalaeva	PROPN
admet-529	202	5	admet	admet	PROPN
admet-529	202	6	&	&	CCONJ
admet-529	202	7	dmpk	dmpk	PROPN
admet-529	202	8	6(2	6(2	NUM
admet-529	202	9	)	)	PUNCT
admet-529	202	10	(	(	PUNCT
admet-529	202	11	2018	2018	NUM
admet-529	202	12	)	)	PUNCT
admet-529	202	13	85	85	NUM
admet-529	202	14	-	-	SYM
admet-529	202	15	104	104	NUM
admet-529	202	16	94	94	NUM
admet-529	202	17	when	when	SCONJ
admet-529	202	18	applied	apply	VERB
admet-529	202	19	to	to	ADP
admet-529	202	20	solvents	solvent	NOUN
admet-529	202	21	,	,	PUNCT
admet-529	202	22	the	the	DET
admet-529	202	23	term	term	NOUN
admet-529	202	24	polarity	polarity	NOUN
admet-529	202	25	covers	cover	VERB
admet-529	202	26	their	their	PRON
admet-529	202	27	overall	overall	ADJ
admet-529	202	28	solvation	solvation	NOUN
admet-529	202	29	capability	capability	NOUN
admet-529	202	30	(	(	PUNCT
admet-529	202	31	solvation	solvation	NOUN
admet-529	202	32	power	power	NOUN
admet-529	202	33	)	)	PUNCT
admet-529	202	34	for	for	ADP
admet-529	202	35	solutes	solute	NOUN
admet-529	202	36	(	(	PUNCT
admet-529	202	37	i.e.	i.e.	X
admet-529	202	38	in	in	ADP
admet-529	202	39	chemical	chemical	ADJ
admet-529	202	40	equilibria	equilibrium	NOUN
admet-529	202	41	:	:	PUNCT
admet-529	202	42	reactants	reactant	NOUN
admet-529	202	43	and	and	CCONJ
admet-529	202	44	products	product	NOUN
admet-529	202	45	,	,	PUNCT
admet-529	202	46	in	in	ADP
admet-529	202	47	reaction	reaction	NOUN
admet-529	202	48	rates	rate	NOUN
admet-529	202	49	:	:	PUNCT
admet-529	202	50	reactants	reactant	NOUN
admet-529	202	51	and	and	CCONJ
admet-529	202	52	activated	activate	VERB
admet-529	202	53	complex	complex	NOUN
admet-529	202	54	,	,	PUNCT
admet-529	202	55	in	in	ADP
admet-529	202	56	light	light	ADJ
admet-529	202	57	absorptions	absorption	NOUN
admet-529	202	58	:	:	PUNCT
admet-529	202	59	ions	ion	NOUN
admet-529	202	60	or	or	CCONJ
admet-529	202	61	molecules	molecule	NOUN
admet-529	202	62	in	in	ADP
admet-529	202	63	the	the	DET
admet-529	202	64	ground	ground	NOUN
admet-529	202	65	and	and	CCONJ
admet-529	202	66	excited	excited	ADJ
admet-529	202	67	state	state	NOUN
admet-529	202	68	)	)	PUNCT
admet-529	202	69	.	.	PUNCT
admet-529	203	1	a	a	DET
admet-529	203	2	solvent	solvent	NOUN
admet-529	203	3	’s	’s	PART
admet-529	203	4	solvation	solvation	NOUN
admet-529	203	5	power	power	NOUN
admet-529	203	6	depends	depend	VERB
admet-529	203	7	on	on	ADP
admet-529	203	8	the	the	DET
admet-529	203	9	action	action	NOUN
admet-529	203	10	of	of	ADP
admet-529	203	11	all	all	DET
admet-529	203	12	possible	possible	ADJ
admet-529	203	13	intermolecular	intermolecular	ADJ
admet-529	203	14	interactions	interaction	NOUN
admet-529	203	15	between	between	ADP
admet-529	203	16	solute	solute	ADJ
admet-529	203	17	ions	ion	NOUN
admet-529	203	18	or	or	CCONJ
admet-529	203	19	molecules	molecule	NOUN
admet-529	203	20	and	and	CCONJ
admet-529	203	21	solvent	solvent	ADJ
admet-529	203	22	molecules	molecule	NOUN
admet-529	203	23	.	.	PUNCT
admet-529	204	1	those	those	DET
admet-529	204	2	interactions	interaction	NOUN
admet-529	204	3	can	can	AUX
admet-529	204	4	be	be	AUX
admet-529	204	5	both	both	CCONJ
admet-529	204	6	nonspecific	nonspecific	ADJ
admet-529	204	7	and	and	CCONJ
admet-529	204	8	specific	specific	ADJ
admet-529	204	9	but	but	CCONJ
admet-529	204	10	exclude	exclude	VERB
admet-529	204	11	the	the	DET
admet-529	204	12	interactions	interaction	NOUN
admet-529	204	13	leading	lead	VERB
admet-529	204	14	to	to	ADP
admet-529	204	15	definite	definite	ADJ
admet-529	204	16	chemical	chemical	NOUN
admet-529	204	17	alterations	alteration	NOUN
admet-529	204	18	of	of	ADP
admet-529	204	19	the	the	DET
admet-529	204	20	ions	ion	NOUN
admet-529	204	21	or	or	CCONJ
admet-529	204	22	molecules	molecule	NOUN
admet-529	204	23	of	of	ADP
admet-529	204	24	the	the	DET
admet-529	204	25	solute	solute	NOUN
admet-529	204	26	.	.	PUNCT
admet-529	205	1	tpsa	tpsa	NOUN
admet-529	205	2	in	in	ADP
admet-529	205	3	the	the	DET
admet-529	205	4	context	context	NOUN
admet-529	205	5	of	of	ADP
admet-529	205	6	drug	drug	NOUN
admet-529	205	7	design	design	NOUN
admet-529	205	8	,	,	PUNCT
admet-529	205	9	the	the	DET
admet-529	205	10	polarity	polarity	NOUN
admet-529	205	11	of	of	ADP
admet-529	205	12	a	a	DET
admet-529	205	13	molecule	molecule	NOUN
admet-529	205	14	has	have	AUX
admet-529	205	15	been	be	AUX
admet-529	205	16	redefined	redefine	VERB
admet-529	205	17	as	as	ADP
admet-529	205	18	its	its	PRON
admet-529	205	19	polar	polar	ADJ
admet-529	205	20	surface	surface	NOUN
admet-529	205	21	area	area	NOUN
admet-529	205	22	(	(	PUNCT
admet-529	205	23	psa	psa	NOUN
admet-529	205	24	)	)	PUNCT
admet-529	205	25	.	.	PUNCT
admet-529	206	1	originally	originally	ADV
admet-529	206	2	computed	compute	VERB
admet-529	206	3	using	use	VERB
admet-529	206	4	molecular	molecular	ADJ
admet-529	206	5	mechanics	mechanic	NOUN
admet-529	206	6	calculations	calculation	NOUN
admet-529	206	7	,	,	PUNCT
admet-529	206	8	the	the	DET
admet-529	206	9	fragments	fragment	NOUN
admet-529	206	10	of	of	ADP
admet-529	206	11	the	the	DET
admet-529	206	12	dynamic	dynamic	ADJ
admet-529	206	13	van	van	PROPN
admet-529	206	14	der	der	NOUN
admet-529	206	15	waals	waal	NOUN
admet-529	206	16	’	’	PART
admet-529	206	17	surface	surface	NOUN
admet-529	206	18	area	area	NOUN
admet-529	206	19	associated	associate	VERB
admet-529	206	20	with	with	ADP
admet-529	206	21	oxygen	oxygen	NOUN
admet-529	206	22	,	,	PUNCT
admet-529	206	23	nitrogen	nitrogen	NOUN
admet-529	206	24	and	and	CCONJ
admet-529	206	25	their	their	PRON
admet-529	206	26	attached	attached	ADJ
admet-529	206	27	hydrogen	hydrogen	NOUN
admet-529	206	28	atoms	atom	NOUN
admet-529	206	29	were	be	AUX
admet-529	206	30	considered	consider	VERB
admet-529	206	31	as	as	ADP
admet-529	206	32	the	the	DET
admet-529	206	33	polar	polar	ADJ
admet-529	206	34	portions	portion	NOUN
admet-529	206	35	of	of	ADP
admet-529	206	36	the	the	DET
admet-529	206	37	molecular	molecular	ADJ
admet-529	206	38	surface	surface	NOUN
admet-529	206	39	area	area	NOUN
admet-529	206	40	.	.	PUNCT
admet-529	207	1	this	this	PRON
admet-529	207	2	showed	show	VERB
admet-529	207	3	correlation	correlation	NOUN
admet-529	207	4	to	to	PART
admet-529	207	5	cell	cell	NOUN
admet-529	207	6	permeability	permeability	NOUN
admet-529	207	7	in	in	ADP
admet-529	207	8	caco-2	caco-2	NUM
admet-529	207	9	cells	cell	NOUN
admet-529	207	10	for	for	ADP
admet-529	207	11	a	a	DET
admet-529	207	12	homologous	homologous	ADJ
admet-529	207	13	series	series	NOUN
admet-529	207	14	of	of	ADP
admet-529	207	15	beta	beta	NOUN
admet-529	207	16	-	-	PUNCT
admet-529	207	17	adrenoreceptor	adrenoreceptor	NOUN
admet-529	207	18	antagonists	antagonist	NOUN
admet-529	207	19	[	[	X
admet-529	207	20	62	62	NUM
admet-529	207	21	]	]	PUNCT
admet-529	207	22	.	.	PUNCT
admet-529	208	1	the	the	DET
admet-529	208	2	popularity	popularity	NOUN
admet-529	208	3	of	of	ADP
admet-529	208	4	psa	psa	NOUN
admet-529	208	5	has	have	AUX
admet-529	208	6	recently	recently	ADV
admet-529	208	7	increased	increase	VERB
admet-529	208	8	significantly	significantly	ADV
admet-529	208	9	,	,	PUNCT
admet-529	208	10	due	due	ADP
admet-529	208	11	to	to	ADP
admet-529	208	12	its	its	PRON
admet-529	208	13	performance	performance	NOUN
admet-529	208	14	in	in	ADP
admet-529	208	15	predicting	predict	VERB
admet-529	208	16	intestinal	intestinal	ADJ
admet-529	208	17	adsorption	adsorption	NOUN
admet-529	208	18	as	as	ADV
admet-529	208	19	well	well	ADV
admet-529	208	20	as	as	ADP
admet-529	208	21	blood	blood	NOUN
admet-529	208	22	-	-	PUNCT
admet-529	208	23	brain	brain	NOUN
admet-529	208	24	barrier	barrier	NOUN
admet-529	208	25	penetration	penetration	NOUN
admet-529	208	26	[	[	PUNCT
admet-529	208	27	63	63	NUM
admet-529	208	28	-	-	SYM
admet-529	208	29	70	70	NUM
admet-529	208	30	]	]	PUNCT
admet-529	208	31	.	.	PUNCT
admet-529	209	1	in	in	ADP
admet-529	209	2	2000	2000	NUM
admet-529	209	3	ertl	ertl	X
admet-529	209	4	et	et	PROPN
admet-529	209	5	al	al	PROPN
admet-529	209	6	.	.	PROPN
admet-529	209	7	introduced	introduce	VERB
admet-529	209	8	the	the	DET
admet-529	209	9	topological	topological	ADJ
admet-529	209	10	polar	polar	ADJ
admet-529	209	11	surface	surface	NOUN
admet-529	209	12	area	area	NOUN
admet-529	209	13	(	(	PUNCT
admet-529	209	14	tpsa)[71	tpsa)[71	PROPN
admet-529	209	15	]	]	PUNCT
admet-529	209	16	,	,	PUNCT
admet-529	209	17	an	an	DET
admet-529	209	18	index	index	NOUN
admet-529	209	19	based	base	VERB
admet-529	209	20	on	on	ADP
admet-529	209	21	the	the	DET
admet-529	209	22	addition	addition	NOUN
admet-529	209	23	of	of	ADP
admet-529	209	24	tabulated	tabulate	VERB
admet-529	209	25	surface	surface	NOUN
admet-529	209	26	contributions	contribution	NOUN
admet-529	209	27	of	of	ADP
admet-529	209	28	polar	polar	ADJ
admet-529	209	29	fragments	fragment	NOUN
admet-529	209	30	.	.	PUNCT
admet-529	210	1	based	base	VERB
admet-529	210	2	on	on	ADP
admet-529	210	3	~35.000	~35.000	X
admet-529	210	4	drug	drug	NOUN
admet-529	210	5	-	-	PUNCT
admet-529	210	6	like	like	ADJ
admet-529	210	7	molecules	molecule	NOUN
admet-529	210	8	,	,	PUNCT
admet-529	210	9	the	the	DET
admet-529	210	10	surface	surface	NOUN
admet-529	210	11	contributions	contribution	NOUN
admet-529	210	12	of	of	ADP
admet-529	210	13	43	43	NUM
admet-529	210	14	fragments	fragment	NOUN
admet-529	210	15	centered	center	VERB
admet-529	210	16	on	on	ADP
admet-529	210	17	polar	polar	ADJ
admet-529	210	18	oxygen	oxygen	NOUN
admet-529	210	19	,	,	PUNCT
admet-529	210	20	nitrogen	nitrogen	NOUN
admet-529	210	21	,	,	PUNCT
admet-529	210	22	phosphorus	phosphorus	NOUN
admet-529	210	23	and	and	CCONJ
admet-529	210	24	sulfur	sulfur	NOUN
admet-529	210	25	were	be	AUX
admet-529	210	26	determined	determine	VERB
admet-529	210	27	by	by	ADP
admet-529	210	28	the	the	DET
admet-529	210	29	least	least	ADJ
admet-529	210	30	square	square	ADJ
admet-529	210	31	fit	fit	ADJ
admet-529	210	32	and	and	CCONJ
admet-529	210	33	tabulated	tabulate	VERB
admet-529	210	34	.	.	PUNCT
admet-529	211	1	this	this	DET
admet-529	211	2	methodology	methodology	NOUN
admet-529	211	3	proved	prove	VERB
admet-529	211	4	2	2	NUM
admet-529	211	5	-	-	SYM
admet-529	211	6	3	3	NUM
admet-529	211	7	orders	order	NOUN
admet-529	211	8	of	of	ADP
admet-529	211	9	magnitude	magnitude	NOUN
admet-529	211	10	less	less	ADV
admet-529	211	11	computationally	computationally	ADV
admet-529	211	12	intensive	intensive	ADJ
admet-529	211	13	than	than	ADP
admet-529	211	14	the	the	DET
admet-529	211	15	previous	previous	ADJ
admet-529	211	16	psa	psa	NOUN
admet-529	211	17	calculations	calculation	NOUN
admet-529	211	18	and	and	CCONJ
admet-529	211	19	gave	give	VERB
admet-529	211	20	similar	similar	ADJ
admet-529	211	21	results	result	NOUN
admet-529	211	22	[	[	X
admet-529	211	23	71	71	NUM
admet-529	211	24	]	]	PUNCT
admet-529	211	25	.	.	PUNCT
admet-529	212	1	the	the	DET
admet-529	212	2	use	use	NOUN
admet-529	212	3	of	of	ADP
admet-529	212	4	psa	psa	NOUN
admet-529	212	5	in	in	ADP
admet-529	212	6	medicinal	medicinal	ADJ
admet-529	212	7	research	research	NOUN
admet-529	212	8	has	have	AUX
admet-529	212	9	since	since	ADV
admet-529	212	10	been	be	AUX
admet-529	212	11	reviewed	review	VERB
admet-529	212	12	by	by	ADP
admet-529	212	13	ertl	ertl	PROPN
admet-529	212	14	[	[	X
admet-529	212	15	72	72	NUM
admet-529	212	16	]	]	PUNCT
admet-529	212	17	.	.	PUNCT
admet-529	213	1	in	in	ADP
admet-529	213	2	addition	addition	NOUN
admet-529	213	3	to	to	ADP
admet-529	213	4	dynamic	dynamic	ADJ
admet-529	213	5	,	,	PUNCT
admet-529	213	6	molecular	molecular	ADJ
admet-529	213	7	and	and	CCONJ
admet-529	213	8	topological	topological	ADJ
admet-529	213	9	polar	polar	ADJ
admet-529	213	10	surface	surface	NOUN
admet-529	213	11	areas	area	NOUN
admet-529	213	12	,	,	PUNCT
admet-529	213	13	quantum	quantum	ADJ
admet-529	213	14	mechanical	mechanical	ADJ
admet-529	213	15	polar	polar	ADJ
admet-529	213	16	surface	surface	NOUN
admet-529	213	17	area	area	NOUN
admet-529	213	18	(	(	PUNCT
admet-529	213	19	qmpsa	qmpsa	NOUN
admet-529	213	20	)	)	PUNCT
admet-529	213	21	was	be	AUX
admet-529	213	22	recently	recently	ADV
admet-529	213	23	introduced	introduce	VERB
admet-529	213	24	and	and	CCONJ
admet-529	213	25	showed	show	VERB
admet-529	213	26	a	a	DET
admet-529	213	27	good	good	ADJ
admet-529	213	28	correlation	correlation	NOUN
admet-529	213	29	with	with	ADP
admet-529	213	30	the	the	DET
admet-529	213	31	fraction	fraction	NOUN
admet-529	213	32	absorbed	absorb	VERB
admet-529	213	33	(	(	PUNCT
admet-529	213	34	fa	fa	NOUN
admet-529	213	35	)	)	PUNCT
admet-529	213	36	after	after	ADP
admet-529	213	37	oral	oral	ADJ
admet-529	213	38	administration	administration	NOUN
admet-529	213	39	for	for	ADP
admet-529	213	40	a	a	DET
admet-529	213	41	set	set	NOUN
admet-529	213	42	of	of	ADP
admet-529	213	43	18	18	NUM
admet-529	213	44	drugs	drug	NOUN
admet-529	213	45	when	when	SCONJ
admet-529	213	46	carboxyl	carboxyl	NOUN
admet-529	213	47	groups	group	NOUN
admet-529	213	48	were	be	AUX
admet-529	213	49	deprotonated	deprotonate	VERB
admet-529	213	50	,	,	PUNCT
admet-529	213	51	suggesting	suggest	VERB
admet-529	213	52	adsorption	adsorption	NOUN
admet-529	213	53	to	to	PART
admet-529	213	54	be	be	AUX
admet-529	213	55	strongly	strongly	ADV
admet-529	213	56	related	relate	VERB
admet-529	213	57	to	to	ADP
admet-529	213	58	polar	polar	ADJ
admet-529	213	59	interactions	interaction	NOUN
admet-529	213	60	of	of	ADP
admet-529	213	61	molecules	molecule	NOUN
admet-529	213	62	in	in	ADP
admet-529	213	63	water	water	NOUN
admet-529	213	64	solution	solution	NOUN
admet-529	213	65	[	[	X
admet-529	213	66	73	73	NUM
admet-529	213	67	]	]	PUNCT
admet-529	213	68	.	.	PUNCT
admet-529	214	1	it	it	PRON
admet-529	214	2	should	should	AUX
admet-529	214	3	be	be	AUX
admet-529	214	4	noted	note	VERB
admet-529	214	5	that	that	SCONJ
admet-529	214	6	significant	significant	ADJ
admet-529	214	7	increases	increase	NOUN
admet-529	214	8	in	in	ADP
admet-529	214	9	computing	compute	VERB
admet-529	214	10	resources	resource	NOUN
admet-529	214	11	are	be	AUX
admet-529	214	12	needed	need	VERB
admet-529	214	13	to	to	PART
admet-529	214	14	generate	generate	VERB
admet-529	214	15	qmpsa	qmpsa	NOUN
admet-529	214	16	,	,	PUNCT
admet-529	214	17	compared	compare	VERB
admet-529	214	18	to	to	ADP
admet-529	214	19	the	the	DET
admet-529	214	20	table	table	NOUN
admet-529	214	21	-	-	PUNCT
admet-529	214	22	entry	entry	NOUN
admet-529	214	23	recalling	recall	VERB
admet-529	214	24	tpsa	tpsa	NOUN
admet-529	214	25	.	.	PUNCT
admet-529	215	1	while	while	SCONJ
admet-529	215	2	mostly	mostly	ADV
admet-529	215	3	used	use	VERB
admet-529	215	4	for	for	ADP
admet-529	215	5	barrier	barrier	NOUN
admet-529	215	6	crossing	crossing	NOUN
admet-529	215	7	prediction	prediction	NOUN
admet-529	215	8	in	in	ADP
admet-529	215	9	an	an	DET
admet-529	215	10	adme	adme	NOUN
admet-529	215	11	context	context	NOUN
admet-529	215	12	,	,	PUNCT
admet-529	215	13	tpsa	tpsa	PROPN
admet-529	215	14	has	have	AUX
admet-529	215	15	also	also	ADV
admet-529	215	16	been	be	AUX
admet-529	215	17	recently	recently	ADV
admet-529	215	18	investigated	investigate	VERB
admet-529	215	19	as	as	ADP
admet-529	215	20	a	a	DET
admet-529	215	21	descriptor	descriptor	NOUN
admet-529	215	22	for	for	ADP
admet-529	215	23	2d	2d	NOUN
admet-529	215	24	-	-	PUNCT
admet-529	215	25	qsar	qsar	NOUN
admet-529	215	26	for	for	ADP
admet-529	215	27	diverse	diverse	ADJ
admet-529	215	28	pharmacological	pharmacological	ADJ
admet-529	215	29	activity	activity	NOUN
admet-529	215	30	data	datum	NOUN
admet-529	215	31	[	[	X
admet-529	215	32	74	74	NUM
admet-529	215	33	]	]	PUNCT
admet-529	215	34	,	,	PUNCT
admet-529	215	35	as	as	ADV
admet-529	215	36	well	well	ADV
admet-529	215	37	as	as	ADP
admet-529	215	38	for	for	ADP
admet-529	215	39	active	active	ADJ
admet-529	215	40	drug	drug	NOUN
admet-529	215	41	transport	transport	NOUN
admet-529	215	42	by	by	ADP
admet-529	215	43	multidrug	multidrug	NOUN
admet-529	215	44	resistance	resistance	NOUN
admet-529	215	45	associated	associate	VERB
admet-529	215	46	protein	protein	NOUN
admet-529	215	47	1	1	NUM
admet-529	215	48	(	(	PUNCT
admet-529	215	49	mrp1	mrp1	NOUN
admet-529	215	50	)	)	PUNCT
admet-529	216	1	[	[	X
admet-529	216	2	75	75	NUM
admet-529	216	3	]	]	PUNCT
admet-529	216	4	.	.	PUNCT
admet-529	217	1	the	the	DET
admet-529	217	2	first	first	ADJ
admet-529	217	3	study	study	NOUN
admet-529	217	4	pointing	pointing	NOUN
admet-529	217	5	to	to	ADP
admet-529	217	6	a	a	DET
admet-529	217	7	hard	hard	ADJ
admet-529	217	8	psa	psa	NOUN
admet-529	217	9	limit	limit	NOUN
admet-529	217	10	dates	date	VERB
admet-529	217	11	back	back	ADV
admet-529	217	12	to	to	ADP
admet-529	217	13	1997	1997	NUM
admet-529	217	14	,	,	PUNCT
admet-529	217	15	in	in	ADP
admet-529	217	16	which	which	PRON
admet-529	217	17	palm	palm	NOUN
admet-529	217	18	et	et	PROPN
admet-529	217	19	al	al	PROPN
admet-529	217	20	.	.	PUNCT
admet-529	218	1	[	[	X
admet-529	218	2	65	65	NUM
admet-529	218	3	]	]	PUNCT
admet-529	218	4	showed	show	VERB
admet-529	218	5	on	on	ADP
admet-529	218	6	a	a	DET
admet-529	218	7	diverse	diverse	ADJ
admet-529	218	8	set	set	NOUN
admet-529	218	9	of	of	ADP
admet-529	218	10	20	20	NUM
admet-529	218	11	model	model	NOUN
admet-529	218	12	drugs	drug	NOUN
admet-529	218	13	,	,	PUNCT
admet-529	218	14	that	that	SCONJ
admet-529	218	15	fully	fully	ADV
admet-529	218	16	absorbed	absorb	VERB
admet-529	218	17	drugs	drug	NOUN
admet-529	218	18	(	(	PUNCT
admet-529	218	19	fa	fa	INTJ
admet-529	218	20	>	>	X
admet-529	218	21	90	90	NUM
admet-529	218	22	%	%	NOUN
admet-529	218	23	)	)	PUNCT
admet-529	218	24	had	have	VERB
admet-529	218	25	a	a	DET
admet-529	218	26	psa	psa	NOUN
admet-529	218	27	≤	≤	NUM
admet-529	218	28	60	60	NUM
admet-529	218	29	å2	å2	NOUN
admet-529	218	30	while	while	SCONJ
admet-529	218	31	drugs	drug	NOUN
admet-529	218	32	that	that	PRON
admet-529	218	33	are	be	AUX
admet-529	218	34	less	less	ADJ
admet-529	218	35	than	than	ADP
admet-529	218	36	10	10	NUM
admet-529	218	37	%	%	NOUN
admet-529	218	38	absorbed	absorb	VERB
admet-529	218	39	had	have	VERB
admet-529	218	40	a	a	DET
admet-529	218	41	psa	psa	NOUN
admet-529	218	42	>	>	X
admet-529	218	43	140	140	NUM
admet-529	218	44	å2	å2	NOUN
admet-529	218	45	.	.	PUNCT
admet-529	219	1	later	later	ADV
admet-529	219	2	,	,	PUNCT
admet-529	219	3	veber	veber	ADV
admet-529	219	4	at	at	ADV
admet-529	219	5	all	all	ADV
admet-529	219	6	[	[	X
admet-529	219	7	76	76	NUM
admet-529	219	8	]	]	PUNCT
admet-529	219	9	showed	show	VERB
admet-529	219	10	that	that	SCONJ
admet-529	219	11	a	a	DET
admet-529	219	12	psa	psa	NOUN
admet-529	219	13	≤	≤	ADJ
admet-529	219	14	140	140	NUM
admet-529	219	15	å2	å2	NOUN
admet-529	219	16	and	and	CCONJ
admet-529	219	17	the	the	DET
admet-529	219	18	number	number	NOUN
admet-529	219	19	of	of	ADP
admet-529	219	20	rotatable	rotatable	ADJ
admet-529	219	21	bonds	bond	NOUN
admet-529	219	22	≤	≤	ADV
admet-529	219	23	10	10	NUM
admet-529	219	24	is	be	AUX
admet-529	219	25	as	as	ADV
admet-529	219	26	efficient	efficient	ADJ
admet-529	219	27	and	and	CCONJ
admet-529	219	28	selective	selective	ADJ
admet-529	219	29	a	a	DET
admet-529	219	30	criterion	criterion	NOUN
admet-529	219	31	as	as	ADP
admet-529	219	32	the	the	DET
admet-529	219	33	lipinski	lipinski	PROPN
admet-529	219	34	’s	’s	PART
admet-529	219	35	ro5	ro5	NOUN
admet-529	219	36	for	for	ADP
admet-529	219	37	selecting	select	VERB
admet-529	219	38	oral	oral	ADJ
admet-529	219	39	bioavailability	bioavailability	NOUN
admet-529	219	40	of	of	ADP
admet-529	219	41	>	>	X
admet-529	219	42	20	20	NUM
admet-529	219	43	-	-	SYM
admet-529	219	44	40	40	NUM
admet-529	219	45	%	%	NOUN
admet-529	219	46	.	.	PUNCT
admet-529	220	1	as	as	ADV
admet-529	220	2	far	far	ADV
admet-529	220	3	as	as	SCONJ
admet-529	220	4	the	the	DET
admet-529	220	5	blood	blood	NOUN
admet-529	220	6	-	-	PUNCT
admet-529	220	7	brain	brain	NOUN
admet-529	220	8	barrier	barrier	NOUN
admet-529	220	9	was	be	AUX
admet-529	220	10	concerned	concern	VERB
admet-529	220	11	,	,	PUNCT
admet-529	220	12	it	it	PRON
admet-529	220	13	was	be	AUX
admet-529	220	14	found	find	VERB
admet-529	220	15	that	that	SCONJ
admet-529	220	16	the	the	DET
admet-529	220	17	upper	upper	ADJ
admet-529	220	18	limit	limit	NOUN
admet-529	220	19	for	for	ADP
admet-529	220	20	psa	psa	NOUN
admet-529	220	21	for	for	ADP
admet-529	220	22	a	a	DET
admet-529	220	23	molecule	molecule	NOUN
admet-529	220	24	to	to	PART
admet-529	220	25	penetrate	penetrate	VERB
admet-529	220	26	the	the	DET
admet-529	220	27	brain	brain	NOUN
admet-529	220	28	was	be	AUX
admet-529	220	29	around	around	ADV
admet-529	220	30	90	90	NUM
admet-529	220	31	å2	å2	NOUN
admet-529	221	1	[	[	X
admet-529	221	2	69,77	69,77	NOUN
admet-529	221	3	]	]	PUNCT
admet-529	221	4	.	.	PUNCT
admet-529	222	1	tpsa	tpsa	NOUN
admet-529	222	2	in	in	ADP
admet-529	222	3	mpo	mpo	PROPN
admet-529	222	4	in	in	ADP
admet-529	222	5	2010	2010	NUM
admet-529	222	6	wager	wager	NOUN
admet-529	222	7	at	at	ADP
admet-529	222	8	al	al	PROPN
admet-529	222	9	introduced	introduce	VERB
admet-529	222	10	the	the	DET
admet-529	222	11	cns	cns	PROPN
admet-529	222	12	mpo	mpo	PROPN
admet-529	222	13	(	(	PUNCT
admet-529	222	14	multiparameter	multiparameter	NOUN
admet-529	222	15	optimization	optimization	NOUN
admet-529	222	16	)	)	PUNCT
admet-529	222	17	desirability	desirability	NOUN
admet-529	222	18	tool	tool	NOUN
admet-529	222	19	,	,	PUNCT
admet-529	222	20	which	which	PRON
admet-529	222	21	incorporated	incorporate	VERB
admet-529	222	22	tpsa	tpsa	NOUN
admet-529	222	23	along	along	ADP
admet-529	222	24	with	with	ADP
admet-529	222	25	5	5	NUM
admet-529	222	26	other	other	ADJ
admet-529	222	27	fundamental	fundamental	ADJ
admet-529	222	28	physicochemical	physicochemical	ADJ
admet-529	222	29	properties	property	NOUN
admet-529	222	30	:	:	PUNCT
admet-529	222	31	clogp	clogp	ADJ
admet-529	222	32	,	,	PUNCT
admet-529	222	33	clogd	clogd	ADJ
admet-529	222	34	,	,	PUNCT
admet-529	222	35	mw	mw	PROPN
admet-529	222	36	,	,	PUNCT
admet-529	222	37	pka	pka	NOUN
admet-529	222	38	,	,	PUNCT
admet-529	222	39	and	and	CCONJ
admet-529	222	40	hbd	hbd	NOUN
admet-529	222	41	.	.	PUNCT
admet-529	223	1	a	a	DET
admet-529	223	2	monotonic	monotonic	ADJ
admet-529	223	3	decreasing	decrease	VERB
admet-529	223	4	function	function	NOUN
admet-529	223	5	was	be	AUX
admet-529	223	6	used	use	VERB
admet-529	223	7	for	for	ADP
admet-529	223	8	clogp	clogp	ADJ
admet-529	223	9	,	,	PUNCT
admet-529	223	10	clogd	clogd	ADJ
admet-529	223	11	,	,	PUNCT
admet-529	223	12	mw	mw	PROPN
admet-529	223	13	,	,	PUNCT
admet-529	223	14	pka	pka	NOUN
admet-529	223	15	,	,	PUNCT
admet-529	223	16	and	and	CCONJ
admet-529	223	17	hbd	hbd	NOUN
admet-529	223	18	,	,	PUNCT
admet-529	223	19	and	and	CCONJ
admet-529	223	20	a	a	DET
admet-529	223	21	hump	hump	NOUN
admet-529	223	22	function	function	NOUN
admet-529	223	23	was	be	AUX
admet-529	223	24	used	use	VERB
admet-529	223	25	to	to	PART
admet-529	223	26	define	define	VERB
admet-529	223	27	tpsa	tpsa	NOUN
admet-529	223	28	(	(	PUNCT
admet-529	223	29	figure	figure	NOUN
admet-529	223	30	8)	8)	NUM
admet-529	223	31	.	.	PUNCT
admet-529	224	1	the	the	DET
admet-529	224	2	cns	cns	PROPN
admet-529	224	3	mpo	mpo	PROPN
admet-529	224	4	desirability	desirability	NOUN
admet-529	224	5	method	method	NOUN
admet-529	224	6	is	be	AUX
admet-529	224	7	quite	quite	ADV
admet-529	224	8	simple	simple	ADJ
admet-529	224	9	,	,	PUNCT
admet-529	224	10	with	with	ADP
admet-529	224	11	parameters	parameter	NOUN
admet-529	224	12	derived	derive	VERB
admet-529	224	13	from	from	ADP
admet-529	224	14	medicinal	medicinal	ADJ
admet-529	224	15	chemistry	chemistry	NOUN
admet-529	224	16	best	good	ADJ
admet-529	224	17	practices	practice	NOUN
admet-529	224	18	,	,	PUNCT
admet-529	224	19	and	and	CCONJ
admet-529	224	20	it	it	PRON
admet-529	224	21	is	be	AUX
admet-529	224	22	able	able	ADJ
admet-529	224	23	to	to	PART
admet-529	224	24	balance	balance	VERB
admet-529	224	25	multiple	multiple	ADJ
admet-529	224	26	variables	variable	NOUN
admet-529	224	27	admet	admet	PROPN
admet-529	224	28	&	&	CCONJ
admet-529	224	29	dmpk	dmpk	PROPN
admet-529	224	30	6(2	6(2	NUM
admet-529	224	31	)	)	PUNCT
admet-529	224	32	(	(	PUNCT
admet-529	224	33	2018	2018	NUM
admet-529	224	34	)	)	PUNCT
admet-529	224	35	85	85	NUM
admet-529	224	36	-	-	SYM
admet-529	224	37	104	104	NUM
admet-529	224	38	leveraging	leverage	VERB
admet-529	224	39	chromatography	chromatography	NOUN
admet-529	224	40	physchem	physchem	NOUN
admet-529	224	41	properties	property	NOUN
admet-529	224	42	in	in	ADP
admet-529	224	43	drug	drug	NOUN
admet-529	224	44	design	design	NOUN
admet-529	224	45	doi	doi	NOUN
admet-529	224	46	:	:	PUNCT
admet-529	224	47	10.5599	10.5599	NUM
admet-529	224	48	/	/	SYM
admet-529	224	49	admet.529	admet.529	NOUN
admet-529	224	50	95	95	NUM
admet-529	224	51	while	while	SCONJ
admet-529	224	52	avoiding	avoid	VERB
admet-529	224	53	hard	hard	ADJ
admet-529	224	54	cut	cut	NOUN
admet-529	224	55	-	-	PUNCT
admet-529	224	56	offs	off	NOUN
admet-529	224	57	.	.	PUNCT
admet-529	225	1	it	it	PRON
admet-529	225	2	demonstrated	demonstrate	VERB
admet-529	225	3	a	a	DET
admet-529	225	4	good	good	ADJ
admet-529	225	5	correlation	correlation	NOUN
admet-529	225	6	between	between	ADP
admet-529	225	7	a	a	DET
admet-529	225	8	high	high	ADJ
admet-529	225	9	score	score	NOUN
admet-529	225	10	(	(	PUNCT
admet-529	225	11	>	>	X
admet-529	225	12	4	4	NUM
admet-529	225	13	out	out	ADP
admet-529	225	14	of	of	ADP
admet-529	225	15	a	a	DET
admet-529	225	16	possible	possible	ADJ
admet-529	225	17	max	max	NOUN
admet-529	225	18	of	of	ADP
admet-529	225	19	6	6	NUM
admet-529	225	20	)	)	PUNCT
admet-529	225	21	and	and	CCONJ
admet-529	225	22	good	good	ADJ
admet-529	225	23	in	in	ADP
admet-529	225	24	vitro	vitro	X
admet-529	225	25	adme	adme	NOUN
admet-529	225	26	properties	property	NOUN
admet-529	225	27	[	[	X
admet-529	225	28	12,78	12,78	NUM
admet-529	225	29	]	]	PUNCT
admet-529	225	30	.	.	PUNCT
admet-529	226	1	figure	figure	NOUN
admet-529	226	2	8	8	NUM
admet-529	226	3	.	.	PUNCT
admet-529	227	1	components	component	NOUN
admet-529	227	2	of	of	ADP
admet-529	227	3	cns	cns	PROPN
admet-529	227	4	multiparameter	multiparameter	NOUN
admet-529	227	5	optimization	optimization	NOUN
admet-529	227	6	desirability	desirability	NOUN
admet-529	227	7	tool	tool	NOUN
admet-529	227	8	(	(	PUNCT
admet-529	227	9	mpo	mpo	PROPN
admet-529	227	10	)	)	PUNCT
admet-529	227	11	epsa	epsa	NOUN
admet-529	227	12	having	have	VERB
admet-529	227	13	access	access	NOUN
admet-529	227	14	to	to	ADP
admet-529	227	15	tpsa	tpsa	NOUN
admet-529	227	16	,	,	PUNCT
admet-529	227	17	a	a	DET
admet-529	227	18	simple	simple	ADJ
admet-529	227	19	,	,	PUNCT
admet-529	227	20	inexpensive	inexpensive	ADJ
admet-529	227	21	and	and	CCONJ
admet-529	227	22	efficient	efficient	ADJ
admet-529	227	23	way	way	NOUN
admet-529	227	24	to	to	PART
admet-529	227	25	assess	assess	VERB
admet-529	227	26	polarity	polarity	NOUN
admet-529	227	27	from	from	ADP
admet-529	227	28	a	a	DET
admet-529	227	29	2d	2d	NUM
admet-529	227	30	structure	structure	NOUN
admet-529	227	31	,	,	PUNCT
admet-529	227	32	which	which	PRON
admet-529	227	33	correlates	correlate	VERB
admet-529	227	34	reasonably	reasonably	ADV
admet-529	227	35	well	well	ADV
admet-529	227	36	with	with	ADP
admet-529	227	37	cell	cell	NOUN
admet-529	227	38	permeability	permeability	NOUN
admet-529	227	39	,	,	PUNCT
admet-529	227	40	the	the	DET
admet-529	227	41	need	need	NOUN
admet-529	227	42	for	for	ADP
admet-529	227	43	a	a	DET
admet-529	227	44	polarity	polarity	NOUN
admet-529	227	45	measurement	measurement	NOUN
admet-529	227	46	was	be	AUX
admet-529	227	47	never	never	ADV
admet-529	227	48	really	really	ADV
admet-529	227	49	felt	feel	VERB
admet-529	227	50	by	by	ADP
admet-529	227	51	drug	drug	NOUN
admet-529	227	52	design	design	NOUN
admet-529	227	53	professionals	professional	NOUN
admet-529	227	54	.	.	PUNCT
admet-529	228	1	while	while	SCONJ
admet-529	228	2	historically	historically	ADV
admet-529	228	3	relevant	relevant	ADJ
admet-529	228	4	for	for	ADP
admet-529	228	5	the	the	DET
admet-529	228	6	targets	target	NOUN
admet-529	228	7	pursued	pursue	VERB
admet-529	228	8	in	in	ADP
admet-529	228	9	the	the	DET
admet-529	228	10	late	late	ADJ
admet-529	228	11	1990s	1990	NOUN
admet-529	228	12	,	,	PUNCT
admet-529	228	13	criteria	criterion	NOUN
admet-529	228	14	such	such	ADJ
admet-529	228	15	as	as	ADP
admet-529	228	16	the	the	DET
admet-529	228	17	ro5	ro5	NOUN
admet-529	228	18	or	or	CCONJ
admet-529	228	19	the	the	DET
admet-529	228	20	veber	veber	ADJ
admet-529	228	21	psa	psa	VERB
admet-529	228	22	-	-	PUNCT
admet-529	228	23	rotatable	rotatable	ADJ
admet-529	228	24	bonds	bond	NOUN
admet-529	228	25	rule	rule	VERB
admet-529	228	26	[	[	X
admet-529	228	27	76	76	NUM
admet-529	228	28	]	]	PUNCT
admet-529	228	29	,	,	PUNCT
admet-529	228	30	tend	tend	VERB
admet-529	228	31	to	to	PART
admet-529	228	32	lose	lose	VERB
admet-529	228	33	traction	traction	NOUN
admet-529	228	34	due	due	ADP
admet-529	228	35	to	to	ADP
admet-529	228	36	the	the	DET
admet-529	228	37	rarity	rarity	NOUN
admet-529	228	38	of	of	ADP
admet-529	228	39	easy	easy	ADJ
admet-529	228	40	targets	target	NOUN
admet-529	228	41	,	,	PUNCT
admet-529	228	42	resulting	result	VERB
admet-529	228	43	in	in	ADP
admet-529	228	44	drug	drug	NOUN
admet-529	228	45	discovery	discovery	NOUN
admet-529	228	46	programs	program	NOUN
admet-529	228	47	having	have	VERB
admet-529	228	48	to	to	PART
admet-529	228	49	foray	foray	VERB
admet-529	228	50	into	into	ADP
admet-529	228	51	more	more	ADV
admet-529	228	52	challenging	challenging	ADJ
admet-529	228	53	chemical	chemical	ADJ
admet-529	228	54	spaces	space	NOUN
admet-529	228	55	.	.	PUNCT
admet-529	229	1	in	in	ADP
admet-529	229	2	jürgen	jürgen	PROPN
admet-529	229	3	drews	drews	PROPN
admet-529	229	4	’	'	PUNCT
admet-529	229	5	words	word	NOUN
admet-529	229	6	“	"	PUNCT
admet-529	229	7	one	one	NUM
admet-529	229	8	truth	truth	NOUN
admet-529	229	9	is	be	AUX
admet-529	229	10	there	there	ADV
admet-529	229	11	for	for	SCONJ
admet-529	229	12	all	all	PRON
admet-529	229	13	to	to	PART
admet-529	229	14	see	see	VERB
admet-529	229	15	:	:	PUNCT
admet-529	229	16	many	many	ADJ
admet-529	229	17	‘	'	PUNCT
admet-529	229	18	easy	easy	ADJ
admet-529	229	19	’	'	PUNCT
admet-529	229	20	targets	target	NOUN
admet-529	229	21	or	or	CCONJ
admet-529	229	22	molecules	molecule	NOUN
admet-529	229	23	have	have	AUX
admet-529	229	24	been	be	AUX
admet-529	229	25	found	find	VERB
admet-529	229	26	and	and	CCONJ
admet-529	229	27	developed	develop	VERB
admet-529	229	28	”	"	PUNCT
admet-529	229	29	[	[	X
admet-529	229	30	79	79	NUM
admet-529	229	31	]	]	PUNCT
admet-529	229	32	.	.	PUNCT
admet-529	230	1	over	over	ADP
admet-529	230	2	the	the	DET
admet-529	230	3	time	time	NOUN
admet-529	230	4	,	,	PUNCT
admet-529	230	5	simplification	simplification	NOUN
admet-529	230	6	of	of	ADP
admet-529	230	7	the	the	DET
admet-529	230	8	polar	polar	ADJ
admet-529	230	9	surface	surface	NOUN
admet-529	230	10	area	area	NOUN
admet-529	230	11	calculations	calculation	VERB
admet-529	230	12	down	down	ADP
admet-529	230	13	to	to	ADP
admet-529	230	14	tpsa	tpsa	NOUN
admet-529	230	15	may	may	AUX
admet-529	230	16	have	have	AUX
admet-529	230	17	led	lead	VERB
admet-529	230	18	to	to	ADP
admet-529	230	19	the	the	DET
admet-529	230	20	false	false	ADJ
admet-529	230	21	equivalency	equivalency	NOUN
admet-529	230	22	of	of	ADP
admet-529	230	23	certain	certain	ADJ
admet-529	230	24	considerations	consideration	NOUN
admet-529	230	25	such	such	ADJ
admet-529	230	26	as	as	ADP
admet-529	230	27	the	the	DET
admet-529	230	28	actual	actual	ADJ
admet-529	230	29	position	position	NOUN
admet-529	230	30	of	of	ADP
admet-529	230	31	a	a	DET
admet-529	230	32	polar	polar	ADJ
admet-529	230	33	group	group	NOUN
admet-529	230	34	in	in	ADP
admet-529	230	35	a	a	DET
admet-529	230	36	molecule	molecule	NOUN
admet-529	230	37	with	with	ADP
admet-529	230	38	regard	regard	NOUN
admet-529	230	39	to	to	ADP
admet-529	230	40	its	its	PRON
admet-529	230	41	immediate	immediate	ADJ
admet-529	230	42	and	and	CCONJ
admet-529	230	43	adjacent	adjacent	ADJ
admet-529	230	44	environment	environment	NOUN
admet-529	230	45	.	.	PUNCT
admet-529	231	1	for	for	ADP
admet-529	231	2	example	example	NOUN
admet-529	231	3	,	,	PUNCT
admet-529	231	4	the	the	DET
admet-529	231	5	tpsa	tpsa	NOUN
admet-529	231	6	values	value	NOUN
admet-529	231	7	for	for	ADP
admet-529	231	8	ortho-	ortho-	NOUN
admet-529	231	9	,	,	PUNCT
admet-529	231	10	metaand	metaand	NOUN
admet-529	231	11	paraanalogues	paraanalogue	NOUN
admet-529	231	12	of	of	ADP
admet-529	231	13	any	any	DET
admet-529	231	14	aromatic	aromatic	ADJ
admet-529	231	15	polar	polar	ADJ
admet-529	231	16	compound	compound	NOUN
admet-529	231	17	are	be	AUX
admet-529	231	18	identical	identical	ADJ
admet-529	231	19	,	,	PUNCT
admet-529	231	20	and	and	CCONJ
admet-529	231	21	similarly	similarly	ADV
admet-529	231	22	,	,	PUNCT
admet-529	231	23	the	the	DET
admet-529	231	24	tpsa	tpsa	NOUN
admet-529	231	25	values	value	NOUN
admet-529	231	26	of	of	ADP
admet-529	231	27	any	any	DET
admet-529	231	28	regioisomers	regioisomer	NOUN
admet-529	231	29	are	be	AUX
admet-529	231	30	also	also	ADV
admet-529	231	31	identical	identical	ADJ
admet-529	231	32	,	,	PUNCT
admet-529	231	33	due	due	ADP
admet-529	231	34	to	to	ADP
admet-529	231	35	the	the	DET
admet-529	231	36	nature	nature	NOUN
admet-529	231	37	of	of	ADP
admet-529	231	38	the	the	DET
admet-529	231	39	tpsa	tpsa	NOUN
admet-529	231	40	calculation	calculation	NOUN
admet-529	231	41	,	,	PUNCT
admet-529	231	42	solely	solely	ADV
admet-529	231	43	based	base	VERB
admet-529	231	44	on	on	ADP
admet-529	231	45	adding	add	VERB
admet-529	231	46	fragment	fragment	ADJ
admet-529	231	47	contributions	contribution	NOUN
admet-529	231	48	to	to	ADP
admet-529	231	49	overall	overall	ADJ
admet-529	231	50	polarity	polarity	NOUN
admet-529	231	51	.	.	PUNCT
admet-529	232	1	we	we	PRON
admet-529	232	2	contend	contend	VERB
admet-529	232	3	here	here	ADV
admet-529	232	4	that	that	SCONJ
admet-529	232	5	each	each	DET
admet-529	232	6	polar	polar	ADJ
admet-529	232	7	fragment	fragment	NOUN
admet-529	232	8	does	do	AUX
admet-529	232	9	not	not	PART
admet-529	232	10	contribute	contribute	VERB
admet-529	232	11	equally	equally	ADV
admet-529	232	12	to	to	ADP
admet-529	232	13	the	the	DET
admet-529	232	14	polar	polar	ADJ
admet-529	232	15	surface	surface	NOUN
admet-529	232	16	area	area	NOUN
admet-529	232	17	of	of	ADP
admet-529	232	18	a	a	DET
admet-529	232	19	molecule	molecule	NOUN
admet-529	232	20	;	;	PUNCT
admet-529	232	21	in	in	ADP
admet-529	232	22	essence	essence	NOUN
admet-529	232	23	advocating	advocate	VERB
admet-529	232	24	a	a	DET
admet-529	232	25	return	return	NOUN
admet-529	232	26	to	to	ADP
admet-529	232	27	a	a	DET
admet-529	232	28	more	more	ADV
admet-529	232	29	“	"	PUNCT
admet-529	232	30	3d	3d	NUM
admet-529	232	31	-	-	PUNCT
admet-529	232	32	psa”-like	psa”-like	NOUN
admet-529	232	33	descriptor	descriptor	NOUN
admet-529	232	34	[	[	X
admet-529	232	35	35,62	35,62	NOUN
admet-529	232	36	]	]	PUNCT
admet-529	232	37	.	.	PUNCT
admet-529	233	1	utilizing	utilize	VERB
admet-529	233	2	separation	separation	NOUN
admet-529	233	3	sciences	science	NOUN
admet-529	233	4	expertise	expertise	NOUN
admet-529	233	5	,	,	PUNCT
admet-529	233	6	a	a	DET
admet-529	233	7	team	team	NOUN
admet-529	233	8	of	of	ADP
admet-529	233	9	pfizer	pfizer	NOUN
admet-529	233	10	scientists	scientist	NOUN
admet-529	233	11	developed	develop	VERB
admet-529	233	12	an	an	DET
admet-529	233	13	assay	assay	NOUN
admet-529	233	14	which	which	PRON
admet-529	233	15	outputs	output	VERB
admet-529	233	16	a	a	DET
admet-529	233	17	polarity	polarity	NOUN
admet-529	233	18	readout	readout	VERB
admet-529	233	19	termed	term	VERB
admet-529	233	20	epsa	epsa	NOUN
admet-529	233	21	(	(	PUNCT
admet-529	233	22	not	not	PART
admet-529	233	23	an	an	DET
admet-529	233	24	acronym	acronym	NOUN
admet-529	233	25	)	)	PUNCT
admet-529	234	1	[	[	X
admet-529	234	2	80	80	NUM
admet-529	234	3	]	]	PUNCT
admet-529	234	4	.	.	PUNCT
admet-529	235	1	the	the	DET
admet-529	235	2	main	main	ADJ
admet-529	235	3	driver	driver	NOUN
admet-529	235	4	behind	behind	ADP
admet-529	235	5	epsa	epsa	NOUN
admet-529	235	6	was	be	AUX
admet-529	235	7	to	to	PART
admet-529	235	8	have	have	VERB
admet-529	235	9	access	access	NOUN
admet-529	235	10	to	to	ADP
admet-529	235	11	a	a	DET
admet-529	235	12	fast	fast	ADJ
admet-529	235	13	,	,	PUNCT
admet-529	235	14	robust	robust	ADJ
admet-529	235	15	method	method	NOUN
admet-529	235	16	capable	capable	ADJ
admet-529	235	17	of	of	ADP
admet-529	235	18	identifying	identify	VERB
admet-529	235	19	the	the	DET
admet-529	235	20	potential	potential	NOUN
admet-529	235	21	for	for	ADP
admet-529	235	22	a	a	DET
admet-529	235	23	compound	compound	NOUN
admet-529	235	24	to	to	PART
admet-529	235	25	form	form	VERB
admet-529	235	26	intramolecular	intramolecular	ADJ
admet-529	235	27	hydrogen	hydrogen	NOUN
admet-529	235	28	bonds	bond	NOUN
admet-529	235	29	(	(	PUNCT
admet-529	235	30	imhb	imhb	NOUN
admet-529	235	31	)	)	PUNCT
admet-529	235	32	enabling	enable	VERB
admet-529	235	33	it	it	PRON
admet-529	235	34	to	to	PART
admet-529	235	35	hide	hide	VERB
admet-529	235	36	polarity	polarity	NOUN
admet-529	235	37	that	that	PRON
admet-529	235	38	might	might	AUX
admet-529	235	39	otherwise	otherwise	ADV
admet-529	235	40	reduce	reduce	VERB
admet-529	235	41	its	its	PRON
admet-529	235	42	passive	passive	ADJ
admet-529	235	43	permeability	permeability	NOUN
admet-529	235	44	.	.	PUNCT
admet-529	236	1	indeed	indeed	ADV
admet-529	236	2	,	,	PUNCT
admet-529	236	3	the	the	DET
admet-529	236	4	identification	identification	NOUN
admet-529	236	5	of	of	ADP
admet-529	236	6	compounds	compound	NOUN
admet-529	236	7	likely	likely	ADJ
admet-529	236	8	to	to	PART
admet-529	236	9	form	form	VERB
admet-529	236	10	imhbs	imhbs	NOUN
admet-529	236	11	is	be	AUX
admet-529	236	12	an	an	DET
admet-529	236	13	important	important	ADJ
admet-529	236	14	drug	drug	NOUN
admet-529	236	15	design	design	NOUN
admet-529	236	16	consideration	consideration	NOUN
admet-529	236	17	given	give	VERB
admet-529	236	18	the	the	DET
admet-529	236	19	correlation	correlation	NOUN
admet-529	236	20	of	of	ADP
admet-529	236	21	intramolecular	intramolecular	ADJ
admet-529	236	22	hydrogen	hydrogen	NOUN
admet-529	236	23	bonding	bonding	NOUN
admet-529	236	24	with	with	ADP
admet-529	236	25	increased	increase	VERB
admet-529	236	26	membrane	membrane	NOUN
admet-529	236	27	permeability	permeability	NOUN
admet-529	236	28	[	[	X
admet-529	236	29	81	81	NUM
admet-529	236	30	-	-	SYM
admet-529	236	31	85	85	NUM
admet-529	236	32	]	]	PUNCT
admet-529	236	33	.	.	PUNCT
admet-529	237	1	the	the	DET
admet-529	237	2	epsa	epsa	NOUN
admet-529	237	3	method	method	NOUN
admet-529	237	4	provides	provide	VERB
admet-529	237	5	,	,	PUNCT
admet-529	237	6	under	under	ADP
admet-529	237	7	controlled	control	VERB
admet-529	237	8	supercritical	supercritical	ADJ
admet-529	237	9	fluid	fluid	NOUN
admet-529	237	10	chromatography	chromatography	NOUN
admet-529	237	11	(	(	PUNCT
admet-529	237	12	sfc	sfc	NOUN
admet-529	237	13	)	)	PUNCT
admet-529	237	14	conditions	condition	NOUN
admet-529	237	15	,	,	PUNCT
admet-529	237	16	an	an	DET
admet-529	237	17	exposed	expose	VERB
admet-529	237	18	/	/	SYM
admet-529	237	19	hidden	hide	VERB
admet-529	237	20	polarity	polarity	NOUN
admet-529	237	21	readout	readout	NOUN
admet-529	237	22	that	that	PRON
admet-529	237	23	is	be	AUX
admet-529	237	24	derived	derive	VERB
admet-529	237	25	from	from	ADP
admet-529	237	26	the	the	DET
admet-529	237	27	retention	retention	NOUN
admet-529	237	28	time	time	NOUN
admet-529	237	29	of	of	ADP
admet-529	237	30	a	a	DET
admet-529	237	31	compound	compound	NOUN
admet-529	237	32	on	on	ADP
admet-529	237	33	a	a	DET
admet-529	237	34	specific	specific	ADJ
admet-529	237	35	column	column	NOUN
admet-529	237	36	.	.	PUNCT
admet-529	238	1	the	the	DET
admet-529	238	2	stationary	stationary	ADJ
admet-529	238	3	phase	phase	NOUN
admet-529	238	4	,	,	PUNCT
admet-529	238	5	(	(	PUNCT
admet-529	238	6	phenomenex	phenomenex	ADV
admet-529	238	7	chirex	chirex	ADJ
admet-529	238	8	3014	3014	NUM
admet-529	238	9	)	)	PUNCT
admet-529	238	10	was	be	AUX
admet-529	238	11	selected	select	VERB
admet-529	238	12	for	for	ADP
admet-529	238	13	its	its	PRON
admet-529	238	14	balance	balance	NOUN
admet-529	238	15	of	of	ADP
admet-529	238	16	lipophilic	lipophilic	ADJ
admet-529	238	17	and	and	CCONJ
admet-529	238	18	polar	polar	ADJ
admet-529	238	19	attributes	attribute	NOUN
admet-529	238	20	and	and	CCONJ
admet-529	238	21	its	its	PRON
admet-529	238	22	capacity	capacity	NOUN
admet-529	238	23	to	to	PART
admet-529	238	24	separate	separate	VERB
admet-529	238	25	compounds	compound	NOUN
admet-529	238	26	with	with	ADP
admet-529	238	27	wide	wide	ADJ
admet-529	238	28	polarity	polarity	NOUN
admet-529	238	29	differences	difference	NOUN
admet-529	238	30	.	.	PUNCT
admet-529	239	1	sfc	sfc	NOUN
admet-529	239	2	,	,	PUNCT
admet-529	239	3	which	which	PRON
admet-529	239	4	essentially	essentially	ADV
admet-529	239	5	uses	use	VERB
admet-529	239	6	normal	normal	ADJ
admet-529	239	7	phase	phase	NOUN
admet-529	239	8	-	-	PUNCT
admet-529	239	9	like	like	ADJ
admet-529	239	10	conditions	condition	NOUN
admet-529	239	11	,	,	PUNCT
admet-529	239	12	provides	provide	VERB
admet-529	239	13	an	an	DET
admet-529	239	14	environment	environment	NOUN
admet-529	239	15	with	with	ADP
admet-529	239	16	a	a	DET
admet-529	239	17	low	low	ADJ
admet-529	239	18	dielectric	dielectric	ADJ
admet-529	239	19	constant	constant	ADJ
admet-529	239	20	conducive	conducive	ADJ
admet-529	239	21	to	to	PART
admet-529	239	22	imhb	imhb	VERB
admet-529	239	23	formation	formation	NOUN
admet-529	239	24	.	.	PUNCT
admet-529	240	1	polar	polar	ADJ
admet-529	240	2	compounds	compound	NOUN
admet-529	240	3	are	be	AUX
admet-529	240	4	retained	retain	VERB
admet-529	240	5	more	more	ADV
admet-529	240	6	under	under	ADP
admet-529	240	7	these	these	DET
admet-529	240	8	conditions	condition	NOUN
admet-529	240	9	,	,	PUNCT
admet-529	240	10	and	and	CCONJ
admet-529	240	11	a	a	DET
admet-529	240	12	low	low	ADJ
admet-529	240	13	-	-	PUNCT
admet-529	240	14	slope	slope	NOUN
admet-529	240	15	gradient	gradient	NOUN
admet-529	240	16	of	of	ADP
admet-529	240	17	methanol	methanol	NOUN
admet-529	240	18	achieves	achieve	VERB
admet-529	240	19	elution	elution	NOUN
admet-529	240	20	based	base	VERB
admet-529	240	21	on	on	ADP
admet-529	240	22	the	the	DET
admet-529	240	23	increasing	increase	VERB
admet-529	240	24	polarity	polarity	NOUN
admet-529	240	25	of	of	ADP
admet-529	240	26	the	the	DET
admet-529	240	27	mobile	mobile	ADJ
admet-529	240	28	phase	phase	NOUN
admet-529	240	29	.	.	PUNCT
admet-529	241	1	in	in	ADP
admet-529	241	2	the	the	DET
admet-529	241	3	cases	case	NOUN
admet-529	241	4	that	that	PRON
admet-529	241	5	have	have	AUX
admet-529	241	6	been	be	AUX
admet-529	241	7	studied	study	VERB
admet-529	241	8	,	,	PUNCT
admet-529	241	9	using	use	VERB
admet-529	241	10	matched	match	VERB
admet-529	241	11	molecular	molecular	ADJ
admet-529	241	12	pairs	pair	NOUN
admet-529	241	13	with	with	ADP
admet-529	241	14	or	or	CCONJ
admet-529	241	15	without	without	ADP
admet-529	241	16	imhbs	imhbs	ADJ
admet-529	241	17	,	,	PUNCT
admet-529	241	18	compounds	compound	NOUN
admet-529	241	19	with	with	ADP
admet-529	241	20	imhb	imhb	NOUN
admet-529	241	21	resulted	result	VERB
admet-529	241	22	in	in	ADP
admet-529	241	23	a	a	DET
admet-529	241	24	significant	significant	ADJ
admet-529	241	25	reduction	reduction	NOUN
admet-529	241	26	in	in	ADP
admet-529	241	27	polarity	polarity	NOUN
admet-529	241	28	and	and	CCONJ
admet-529	241	29	eluted	elute	VERB
admet-529	241	30	earlier	early	ADV
admet-529	241	31	in	in	ADP
admet-529	241	32	the	the	DET
admet-529	241	33	chromatogram	chromatogram	PROPN
admet-529	241	34	.	.	PUNCT
admet-529	242	1	results	result	NOUN
admet-529	242	2	are	be	AUX
admet-529	242	3	normalized	normalize	VERB
admet-529	242	4	through	through	ADP
admet-529	242	5	the	the	DET
admet-529	242	6	use	use	NOUN
admet-529	242	7	of	of	ADP
admet-529	242	8	calibration	calibration	NOUN
admet-529	242	9	standards	standard	NOUN
admet-529	242	10	generating	generate	VERB
admet-529	242	11	a	a	DET
admet-529	242	12	linear	linear	ADJ
admet-529	242	13	relationship	relationship	NOUN
admet-529	242	14	between	between	ADP
admet-529	242	15	retention	retention	NOUN
admet-529	242	16	times	time	NOUN
admet-529	242	17	and	and	CCONJ
admet-529	242	18	epsa	epsa	NOUN
admet-529	242	19	values	value	NOUN
admet-529	242	20	[	[	X
admet-529	242	21	80	80	NUM
admet-529	242	22	]	]	PUNCT
admet-529	242	23	.	.	PUNCT
admet-529	243	1	this	this	PRON
admet-529	243	2	is	be	AUX
admet-529	243	3	possible	possible	ADJ
admet-529	243	4	to	to	PART
admet-529	243	5	confirm	confirm	VERB
admet-529	243	6	or	or	CCONJ
admet-529	243	7	disprove	disprove	VERB
admet-529	243	8	the	the	DET
admet-529	243	9	presence	presence	NOUN
admet-529	243	10	of	of	ADP
admet-529	243	11	an	an	DET
admet-529	243	12	intramolecular	intramolecular	ADJ
admet-529	243	13	hydrogen	hydrogen	NOUN
admet-529	243	14	bond	bond	NOUN
admet-529	243	15	(	(	PUNCT
admet-529	243	16	imhb	imhb	NOUN
admet-529	243	17	)	)	PUNCT
admet-529	243	18	in	in	ADP
admet-529	243	19	small	small	ADJ
admet-529	243	20	g.h	g.h	PROPN
admet-529	243	21	.	.	PROPN
admet-529	243	22	goetz	goetz	PROPN
admet-529	243	23	and	and	CCONJ
admet-529	243	24	m.	m.	NOUN
admet-529	243	25	shalaeva	shalaeva	PROPN
admet-529	243	26	admet	admet	PROPN
admet-529	243	27	&	&	CCONJ
admet-529	243	28	dmpk	dmpk	PROPN
admet-529	243	29	6(2	6(2	NUM
admet-529	243	30	)	)	PUNCT
admet-529	243	31	(	(	PUNCT
admet-529	243	32	2018	2018	NUM
admet-529	243	33	)	)	PUNCT
admet-529	243	34	85	85	NUM
admet-529	243	35	-	-	SYM
admet-529	243	36	104	104	NUM
admet-529	243	37	96	96	NUM
admet-529	243	38	molecules	molecule	NOUN
admet-529	243	39	or	or	CCONJ
admet-529	243	40	peptides	peptide	NOUN
admet-529	243	41	using	use	VERB
admet-529	243	42	epsa	epsa	NOUN
admet-529	243	43	and	and	CCONJ
admet-529	243	44	pairwise	pairwise	NOUN
admet-529	243	45	analysis	analysis	NOUN
admet-529	243	46	.	.	PUNCT
admet-529	244	1	such	such	ADJ
admet-529	244	2	imhbs	imhbs	NOUN
admet-529	244	3	are	be	AUX
admet-529	244	4	a	a	DET
admet-529	244	5	critical	critical	ADJ
admet-529	244	6	factor	factor	NOUN
admet-529	244	7	affecting	affect	VERB
admet-529	244	8	the	the	DET
admet-529	244	9	conformation	conformation	NOUN
admet-529	244	10	of	of	ADP
admet-529	244	11	molecules	molecule	NOUN
admet-529	244	12	and	and	CCONJ
admet-529	244	13	can	can	AUX
admet-529	244	14	have	have	VERB
admet-529	244	15	a	a	DET
admet-529	244	16	direct	direct	ADJ
admet-529	244	17	impact	impact	NOUN
admet-529	244	18	on	on	ADP
admet-529	244	19	their	their	PRON
admet-529	244	20	absorption	absorption	NOUN
admet-529	244	21	into	into	ADP
admet-529	244	22	the	the	DET
admet-529	244	23	human	human	ADJ
admet-529	244	24	body	body	NOUN
admet-529	244	25	,	,	PUNCT
admet-529	244	26	their	their	PRON
admet-529	244	27	permeability	permeability	NOUN
admet-529	244	28	into	into	ADP
admet-529	244	29	target	target	NOUN
admet-529	244	30	cells	cell	NOUN
admet-529	244	31	,	,	PUNCT
admet-529	244	32	and	and	CCONJ
admet-529	244	33	even	even	ADV
admet-529	244	34	their	their	PRON
admet-529	244	35	potency	potency	NOUN
admet-529	244	36	against	against	ADP
admet-529	244	37	therapeutic	therapeutic	ADJ
admet-529	244	38	targets	target	NOUN
admet-529	244	39	.	.	PUNCT
admet-529	245	1	this	this	DET
admet-529	245	2	method	method	NOUN
admet-529	245	3	has	have	AUX
admet-529	245	4	been	be	AUX
admet-529	245	5	successfully	successfully	ADV
admet-529	245	6	used	use	VERB
admet-529	245	7	in	in	ADP
admet-529	245	8	a	a	DET
admet-529	245	9	small	small	ADJ
admet-529	245	10	molecule	molecule	NOUN
admet-529	245	11	medicinal	medicinal	ADJ
admet-529	245	12	chemistry	chemistry	NOUN
admet-529	245	13	project	project	NOUN
admet-529	245	14	to	to	PART
admet-529	245	15	assess	assess	VERB
admet-529	245	16	exposed	expose	VERB
admet-529	245	17	polarities	polarity	NOUN
admet-529	245	18	of	of	ADP
admet-529	245	19	their	their	PRON
admet-529	245	20	lead	lead	NOUN
admet-529	245	21	compounds	compound	NOUN
admet-529	245	22	.	.	PUNCT
admet-529	246	1	cheng	cheng	PROPN
admet-529	246	2	et	et	PROPN
admet-529	246	3	al	al	PROPN
admet-529	246	4	.	.	PUNCT
admet-529	247	1	[	[	X
admet-529	247	2	86	86	NUM
admet-529	247	3	]	]	PUNCT
admet-529	247	4	determined	determined	ADJ
admet-529	247	5	epsa	epsa	NOUN
admet-529	247	6	for	for	ADP
admet-529	247	7	their	their	PRON
admet-529	247	8	mechanistic	mechanistic	ADJ
admet-529	247	9	target	target	NOUN
admet-529	247	10	of	of	ADP
admet-529	247	11	rapamycin	rapamycin	NOUN
admet-529	247	12	(	(	PUNCT
admet-529	247	13	mtor	mtor	NOUN
admet-529	247	14	)	)	PUNCT
admet-529	247	15	,	,	PUNCT
admet-529	247	16	phosphatidylinositol-3	phosphatidylinositol-3	CCONJ
admet-529	247	17	kinase	kinase	NOUN
admet-529	247	18	(	(	PUNCT
admet-529	247	19	pi3k	pi3k	NOUN
admet-529	247	20	)	)	PUNCT
admet-529	247	21	dual	dual	ADJ
admet-529	247	22	inhibitors	inhibitor	NOUN
admet-529	247	23	series	series	NOUN
admet-529	247	24	and	and	CCONJ
admet-529	247	25	found	find	VERB
admet-529	247	26	no	no	DET
admet-529	247	27	direct	direct	ADJ
admet-529	247	28	correlation	correlation	NOUN
admet-529	247	29	between	between	ADP
admet-529	247	30	epsa	epsa	NOUN
admet-529	247	31	and	and	CCONJ
admet-529	247	32	tpsa	tpsa	NOUN
admet-529	247	33	.	.	PUNCT
admet-529	248	1	however	however	ADV
admet-529	248	2	,	,	PUNCT
admet-529	248	3	they	they	PRON
admet-529	248	4	showed	show	VERB
admet-529	248	5	that	that	SCONJ
admet-529	248	6	the	the	DET
admet-529	248	7	formation	formation	NOUN
admet-529	248	8	of	of	ADP
admet-529	248	9	imhb	imhb	NOUN
admet-529	248	10	can	can	AUX
admet-529	248	11	significantly	significantly	ADV
admet-529	248	12	reduce	reduce	VERB
admet-529	248	13	the	the	DET
admet-529	248	14	effective	effective	ADJ
admet-529	248	15	polar	polar	ADJ
admet-529	248	16	surface	surface	NOUN
admet-529	248	17	area	area	NOUN
admet-529	248	18	.	.	PUNCT
admet-529	249	1	suggesting	suggest	VERB
admet-529	249	2	that	that	SCONJ
admet-529	249	3	for	for	ADP
admet-529	249	4	designs	design	NOUN
admet-529	249	5	with	with	ADP
admet-529	249	6	high	high	ADJ
admet-529	249	7	tpsa	tpsa	NOUN
admet-529	249	8	,	,	PUNCT
admet-529	249	9	the	the	DET
admet-529	249	10	introduction	introduction	NOUN
admet-529	249	11	of	of	ADP
admet-529	249	12	an	an	DET
admet-529	249	13	imhb	imhb	NOUN
admet-529	249	14	can	can	AUX
admet-529	249	15	help	help	VERB
admet-529	249	16	achieve	achieve	VERB
admet-529	249	17	good	good	ADJ
admet-529	249	18	permeability	permeability	NOUN
admet-529	249	19	and	and	CCONJ
admet-529	249	20	cellular	cellular	ADJ
admet-529	249	21	potency	potency	NOUN
admet-529	249	22	by	by	ADP
admet-529	249	23	modulating	modulate	VERB
admet-529	249	24	the	the	DET
admet-529	249	25	epsa	epsa	NOUN
admet-529	249	26	to	to	ADP
admet-529	249	27	a	a	DET
admet-529	249	28	desirable	desirable	ADJ
admet-529	249	29	range	range	NOUN
admet-529	249	30	.	.	PUNCT
admet-529	250	1	indeed	indeed	ADV
admet-529	250	2	,	,	PUNCT
admet-529	250	3	several	several	ADJ
admet-529	250	4	compounds	compound	NOUN
admet-529	250	5	,	,	PUNCT
admet-529	250	6	with	with	ADP
admet-529	250	7	tpsa	tpsa	NOUN
admet-529	250	8	greater	great	ADJ
admet-529	250	9	than	than	ADP
admet-529	250	10	135	135	NUM
admet-529	250	11	å2	å2	NOUN
admet-529	250	12	,	,	PUNCT
admet-529	250	13	exhibit	exhibit	NOUN
admet-529	250	14	epsa	epsa	NOUN
admet-529	250	15	values	value	NOUN
admet-529	250	16	between	between	ADP
admet-529	250	17	82	82	NUM
admet-529	250	18	and	and	CCONJ
admet-529	250	19	101	101	NUM
admet-529	250	20	,	,	PUNCT
admet-529	250	21	which	which	PRON
admet-529	250	22	is	be	AUX
admet-529	250	23	a	a	DET
admet-529	250	24	range	range	NOUN
admet-529	250	25	capable	capable	ADJ
admet-529	250	26	for	for	ADP
admet-529	250	27	this	this	DET
admet-529	250	28	series	series	NOUN
admet-529	250	29	of	of	ADP
admet-529	250	30	yielding	yield	VERB
admet-529	250	31	permeability	permeability	NOUN
admet-529	250	32	and	and	CCONJ
admet-529	250	33	cellular	cellular	ADJ
admet-529	250	34	potency	potency	NOUN
admet-529	250	35	.	.	PUNCT
admet-529	251	1	wakenhut	wakenhut	PROPN
admet-529	251	2	et	et	PROPN
admet-529	251	3	al	al	PROPN
admet-529	251	4	.	.	PUNCT
admet-529	252	1	[	[	X
admet-529	252	2	87	87	NUM
admet-529	252	3	]	]	PUNCT
admet-529	252	4	determined	determine	VERB
admet-529	252	5	epsa	epsa	NOUN
admet-529	252	6	for	for	ADP
admet-529	252	7	non	non	ADJ
admet-529	252	8	-	-	ADJ
admet-529	252	9	structural	structural	ADJ
admet-529	252	10	protein	protein	NOUN
admet-529	252	11	5a	5a	NUM
admet-529	252	12	(	(	PUNCT
admet-529	252	13	ns5a	ns5a	NOUN
admet-529	252	14	)	)	PUNCT
admet-529	252	15	inhibitors	inhibitor	NOUN
admet-529	252	16	and	and	CCONJ
admet-529	252	17	notably	notably	ADV
admet-529	252	18	compared	compare	VERB
admet-529	252	19	two	two	NUM
admet-529	252	20	analogues	analogue	NOUN
admet-529	252	21	:	:	PUNCT
admet-529	252	22	12	12	NUM
admet-529	252	23	and	and	CCONJ
admet-529	252	24	13	13	NUM
admet-529	252	25	.	.	PUNCT
admet-529	253	1	compound	compound	NOUN
admet-529	253	2	12	12	NUM
admet-529	253	3	has	have	VERB
admet-529	253	4	less	less	ADJ
admet-529	253	5	hbd	hbd	NOUN
admet-529	253	6	and	and	CCONJ
admet-529	253	7	hba	hba	NOUN
admet-529	253	8	,	,	PUNCT
admet-529	253	9	less	less	ADV
admet-529	253	10	rotatable	rotatable	ADJ
admet-529	253	11	bonds	bond	NOUN
admet-529	253	12	,	,	PUNCT
admet-529	253	13	lower	low	ADJ
admet-529	253	14	tpsa	tpsa	NOUN
admet-529	253	15	(	(	PUNCT
admet-529	253	16	105	105	NUM
admet-529	253	17	å2	å2	NOUN
admet-529	253	18	)	)	PUNCT
admet-529	253	19	and	and	CCONJ
admet-529	253	20	,	,	PUNCT
admet-529	253	21	by	by	ADP
admet-529	253	22	all	all	DET
admet-529	253	23	standard	standard	ADJ
admet-529	253	24	medicinal	medicinal	ADJ
admet-529	253	25	chemistry	chemistry	NOUN
admet-529	253	26	principles	principle	NOUN
admet-529	253	27	,	,	PUNCT
admet-529	253	28	12	12	NUM
admet-529	253	29	was	be	AUX
admet-529	253	30	expected	expect	VERB
admet-529	253	31	to	to	PART
admet-529	253	32	be	be	AUX
admet-529	253	33	more	more	ADV
admet-529	253	34	permeable	permeable	ADJ
admet-529	253	35	than	than	ADP
admet-529	253	36	13	13	NUM
admet-529	253	37	(	(	PUNCT
admet-529	253	38	tpsa	tpsa	NOUN
admet-529	253	39	175	175	NUM
admet-529	253	40	å2	å2	NOUN
admet-529	253	41	)	)	PUNCT
admet-529	253	42	.	.	PUNCT
admet-529	254	1	it	it	PRON
admet-529	254	2	turned	turn	VERB
admet-529	254	3	out	out	ADP
admet-529	254	4	that	that	SCONJ
admet-529	254	5	the	the	DET
admet-529	254	6	opposite	opposite	ADJ
admet-529	254	7	was	be	AUX
admet-529	254	8	true	true	ADJ
admet-529	254	9	;	;	PUNCT
admet-529	254	10	compound	compound	NOUN
admet-529	254	11	12	12	NUM
admet-529	254	12	was	be	AUX
admet-529	254	13	not	not	PART
admet-529	254	14	permeable	permeable	ADJ
admet-529	254	15	while	while	SCONJ
admet-529	254	16	13	13	NUM
admet-529	254	17	was	be	AUX
admet-529	254	18	permeable	permeable	ADJ
admet-529	254	19	.	.	PUNCT
admet-529	255	1	compound	compound	NOUN
admet-529	255	2	12	12	NUM
admet-529	255	3	had	have	VERB
admet-529	255	4	an	an	DET
admet-529	255	5	exposed	expose	VERB
admet-529	255	6	polarity	polarity	NOUN
admet-529	255	7	value	value	NOUN
admet-529	255	8	(	(	PUNCT
admet-529	255	9	epsa	epsa	NOUN
admet-529	255	10	)	)	PUNCT
admet-529	255	11	of	of	ADP
admet-529	255	12	128	128	NUM
admet-529	255	13	,	,	PUNCT
admet-529	255	14	while	while	SCONJ
admet-529	255	15	the	the	DET
admet-529	255	16	epsa	epsa	NOUN
admet-529	255	17	value	value	NOUN
admet-529	255	18	of	of	ADP
admet-529	255	19	13	13	NUM
admet-529	255	20	was	be	AUX
admet-529	255	21	103	103	NUM
admet-529	255	22	,	,	PUNCT
admet-529	255	23	significantly	significantly	ADV
admet-529	255	24	lower	low	ADJ
admet-529	255	25	than	than	ADP
admet-529	255	26	for	for	ADP
admet-529	255	27	12	12	NUM
admet-529	255	28	.	.	PUNCT
admet-529	256	1	these	these	DET
admet-529	256	2	facts	fact	NOUN
admet-529	256	3	can	can	AUX
admet-529	256	4	be	be	AUX
admet-529	256	5	explained	explain	VERB
admet-529	256	6	by	by	ADP
admet-529	256	7	the	the	DET
admet-529	256	8	peripheral	peripheral	ADJ
admet-529	256	9	functionality	functionality	NOUN
admet-529	256	10	capable	capable	ADJ
admet-529	256	11	of	of	ADP
admet-529	256	12	forming	form	VERB
admet-529	256	13	imhbs	imhbs	NOUN
admet-529	256	14	in	in	ADP
admet-529	256	15	13	13	NUM
admet-529	256	16	within	within	ADP
admet-529	256	17	a	a	DET
admet-529	256	18	membrane	membrane	NOUN
admet-529	256	19	environment	environment	NOUN
admet-529	256	20	,	,	PUNCT
admet-529	256	21	thereby	thereby	ADV
admet-529	256	22	masking	mask	VERB
admet-529	256	23	h	h	NOUN
admet-529	256	24	-	-	PUNCT
admet-529	256	25	bonding	bonding	NOUN
admet-529	256	26	(	(	PUNCT
admet-529	256	27	hbd	hbd	NOUN
admet-529	256	28	and	and	CCONJ
admet-529	256	29	hba	hba	NOUN
admet-529	256	30	)	)	PUNCT
admet-529	256	31	character	character	NOUN
admet-529	256	32	and	and	CCONJ
admet-529	256	33	contributing	contribute	VERB
admet-529	256	34	to	to	ADP
admet-529	256	35	passive	passive	ADJ
admet-529	256	36	permeability	permeability	NOUN
admet-529	256	37	,	,	PUNCT
admet-529	256	38	as	as	SCONJ
admet-529	256	39	compared	compare	VERB
admet-529	256	40	with	with	ADP
admet-529	256	41	the	the	DET
admet-529	256	42	more	more	ADV
admet-529	256	43	extended	extended	ADJ
admet-529	256	44	conformations	conformation	NOUN
admet-529	256	45	available	available	ADJ
admet-529	256	46	to	to	ADP
admet-529	256	47	compounds	compound	NOUN
admet-529	256	48	such	such	ADJ
admet-529	256	49	as	as	ADP
admet-529	256	50	12	12	NUM
admet-529	256	51	incapables	incapable	NOUN
admet-529	256	52	of	of	ADP
admet-529	256	53	forming	form	VERB
admet-529	256	54	imhbs	imhbs	NOUN
admet-529	256	55	(	(	PUNCT
admet-529	256	56	figure	figure	NOUN
admet-529	256	57	9	9	NUM
admet-529	256	58	)	)	PUNCT
admet-529	256	59	.	.	PUNCT
admet-529	257	1	the	the	DET
admet-529	257	2	team	team	NOUN
admet-529	257	3	based	base	VERB
admet-529	257	4	its	its	PRON
admet-529	257	5	subsequent	subsequent	ADJ
admet-529	257	6	designs	design	NOUN
admet-529	257	7	on	on	ADP
admet-529	257	8	enabling	enable	VERB
admet-529	257	9	imhb	imhb	ADJ
admet-529	257	10	formation	formation	NOUN
admet-529	257	11	within	within	ADP
admet-529	257	12	the	the	DET
admet-529	257	13	analogues	analogue	NOUN
admet-529	257	14	being	be	AUX
admet-529	257	15	developed	develop	VERB
admet-529	257	16	.	.	PUNCT
admet-529	258	1	figure	figure	NOUN
admet-529	258	2	9	9	NUM
admet-529	258	3	.	.	PUNCT
admet-529	258	4	representation	representation	NOUN
admet-529	258	5	of	of	ADP
admet-529	258	6	compound	compound	NOUN
admet-529	258	7	12	12	NUM
admet-529	258	8	and	and	CCONJ
admet-529	258	9	13	13	NUM
admet-529	258	10	.	.	PUNCT
admet-529	259	1	compound	compound	NOUN
admet-529	259	2	13	13	NUM
admet-529	259	3	initially	initially	ADV
admet-529	259	4	in	in	ADP
admet-529	259	5	solution	solution	NOUN
admet-529	259	6	phase	phase	NOUN
admet-529	259	7	(	(	PUNCT
admet-529	259	8	6	6	NUM
admet-529	259	9	hba	hba	NOUN
admet-529	259	10	,	,	PUNCT
admet-529	259	11	4	4	NUM
admet-529	259	12	hbd	hbd	NOUN
admet-529	259	13	,	,	PUNCT
admet-529	259	14	psa	psa	VERB
admet-529	259	15	=	=	NOUN
admet-529	259	16	175	175	NUM
admet-529	259	17	å	å	PROPN
admet-529	259	18	2	2	NUM
admet-529	259	19	)	)	PUNCT
admet-529	259	20	and	and	CCONJ
admet-529	259	21	as	as	SCONJ
admet-529	259	22	it	it	PRON
admet-529	259	23	traverses	traverse	VERB
admet-529	259	24	a	a	DET
admet-529	259	25	hydrophobic	hydrophobic	NOUN
admet-529	259	26	membrane	membrane	NOUN
admet-529	259	27	(	(	PUNCT
admet-529	259	28	4	4	NUM
admet-529	259	29	hba	hba	NOUN
admet-529	259	30	,	,	PUNCT
admet-529	259	31	2	2	NUM
admet-529	259	32	hbd	hbd	NOUN
admet-529	259	33	,	,	PUNCT
admet-529	259	34	3d	3d	NOUN
admet-529	259	35	-	-	PUNCT
admet-529	259	36	psa~120	psa~120	ADJ
admet-529	259	37	å	å	PROPN
admet-529	259	38	2	2	NUM
admet-529	259	39	)	)	PUNCT
admet-529	259	40	as	as	ADP
admet-529	259	41	a	a	DET
admet-529	259	42	possible	possible	ADJ
admet-529	259	43	explanation	explanation	NOUN
admet-529	259	44	of	of	ADP
admet-529	259	45	the	the	DET
admet-529	259	46	good	good	ADJ
admet-529	259	47	membrane	membrane	NOUN
admet-529	259	48	permeability	permeability	NOUN
admet-529	259	49	of	of	ADP
admet-529	259	50	13	13	NUM
admet-529	259	51	.	.	PUNCT
admet-529	260	1	adapted	adapt	VERB
admet-529	260	2	from	from	ADP
admet-529	260	3	[	[	X
admet-529	260	4	87	87	NUM
admet-529	260	5	]	]	PUNCT
admet-529	260	6	copyright	copyright	NOUN
admet-529	260	7	(	(	PUNCT
admet-529	260	8	2014	2014	NUM
admet-529	260	9	)	)	PUNCT
admet-529	260	10	,	,	PUNCT
admet-529	260	11	with	with	ADP
admet-529	260	12	permission	permission	NOUN
admet-529	260	13	from	from	ADP
admet-529	260	14	wiley	wiley	PROPN
admet-529	260	15	.	.	PUNCT
admet-529	261	1	epsa	epsa	NOUN
admet-529	261	2	and	and	CCONJ
admet-529	261	3	peptides	peptide	NOUN
admet-529	261	4	once	once	ADV
admet-529	261	5	epsa	epsa	NOUN
admet-529	261	6	was	be	AUX
admet-529	261	7	established	establish	VERB
admet-529	261	8	as	as	ADP
admet-529	261	9	a	a	DET
admet-529	261	10	viable	viable	ADJ
admet-529	261	11	polarity	polarity	NOUN
admet-529	261	12	monitoring	monitor	VERB
admet-529	261	13	tool	tool	NOUN
admet-529	261	14	for	for	ADP
admet-529	261	15	small	small	ADJ
admet-529	261	16	molecules	molecule	NOUN
admet-529	261	17	,	,	PUNCT
admet-529	261	18	its	its	PRON
admet-529	261	19	remit	remit	NOUN
admet-529	261	20	was	be	AUX
admet-529	261	21	expanded	expand	VERB
admet-529	261	22	to	to	ADP
admet-529	261	23	peptides	peptide	NOUN
admet-529	261	24	,	,	PUNCT
admet-529	261	25	notably	notably	ADV
admet-529	261	26	cyclic	cyclic	ADJ
admet-529	261	27	peptides	peptide	NOUN
admet-529	261	28	,	,	PUNCT
admet-529	261	29	which	which	PRON
admet-529	261	30	have	have	AUX
admet-529	261	31	generally	generally	ADV
admet-529	261	32	demonstrated	demonstrate	VERB
admet-529	261	33	insufficient	insufficient	ADJ
admet-529	261	34	permeability	permeability	NOUN
admet-529	261	35	to	to	PART
admet-529	261	36	be	be	AUX
admet-529	261	37	used	use	VERB
admet-529	261	38	as	as	ADP
admet-529	261	39	oral	oral	ADJ
admet-529	261	40	drugs	drug	NOUN
admet-529	261	41	.	.	PUNCT
admet-529	262	1	guiding	guide	VERB
admet-529	262	2	the	the	DET
admet-529	262	3	design	design	NOUN
admet-529	262	4	of	of	ADP
admet-529	262	5	such	such	ADJ
admet-529	262	6	peptides	peptide	NOUN
admet-529	262	7	without	without	ADP
admet-529	262	8	a	a	DET
admet-529	262	9	reliable	reliable	ADJ
admet-529	262	10	permeability	permeability	NOUN
admet-529	262	11	monitoring	monitoring	NOUN
admet-529	262	12	method	method	NOUN
admet-529	262	13	is	be	AUX
admet-529	262	14	a	a	DET
admet-529	262	15	challenge	challenge	NOUN
admet-529	262	16	.	.	PUNCT
admet-529	263	1	since	since	SCONJ
admet-529	263	2	for	for	ADP
admet-529	263	3	peptides	peptide	NOUN
admet-529	263	4	,	,	PUNCT
admet-529	263	5	the	the	DET
admet-529	263	6	main	main	ADJ
admet-529	263	7	obstacle	obstacle	NOUN
admet-529	263	8	to	to	ADP
admet-529	263	9	permeability	permeability	NOUN
admet-529	263	10	is	be	AUX
admet-529	263	11	polarity	polarity	NOUN
admet-529	263	12	,	,	PUNCT
admet-529	263	13	the	the	DET
admet-529	263	14	epsa	epsa	NOUN
admet-529	263	15	experiment	experiment	NOUN
admet-529	263	16	was	be	AUX
admet-529	263	17	a	a	DET
admet-529	263	18	perfect	perfect	ADJ
admet-529	263	19	fit	fit	NOUN
admet-529	263	20	.	.	PUNCT
admet-529	264	1	admet	admet	PROPN
admet-529	264	2	&	&	CCONJ
admet-529	264	3	dmpk	dmpk	PROPN
admet-529	264	4	6(2	6(2	NUM
admet-529	264	5	)	)	PUNCT
admet-529	264	6	(	(	PUNCT
admet-529	264	7	2018	2018	NUM
admet-529	264	8	)	)	PUNCT
admet-529	264	9	85	85	NUM
admet-529	264	10	-	-	SYM
admet-529	264	11	104	104	NUM
admet-529	264	12	leveraging	leverage	VERB
admet-529	264	13	chromatography	chromatography	NOUN
admet-529	264	14	physchem	physchem	NOUN
admet-529	264	15	properties	property	NOUN
admet-529	264	16	in	in	ADP
admet-529	264	17	drug	drug	NOUN
admet-529	264	18	design	design	NOUN
admet-529	264	19	doi	doi	NOUN
admet-529	264	20	:	:	PUNCT
admet-529	264	21	10.5599	10.5599	NUM
admet-529	264	22	/	/	SYM
admet-529	264	23	admet.529	admet.529	NOUN
admet-529	264	24	97	97	NUM
admet-529	264	25	goetz	goetz	PROPN
admet-529	264	26	at	at	ADP
admet-529	264	27	al	al	PROPN
admet-529	264	28	.	.	PUNCT
admet-529	265	1	[	[	X
admet-529	265	2	88	88	NUM
admet-529	265	3	]	]	PUNCT
admet-529	265	4	have	have	AUX
admet-529	265	5	reported	report	VERB
admet-529	265	6	a	a	DET
admet-529	265	7	project	project	NOUN
admet-529	265	8	team	team	NOUN
admet-529	265	9	design	design	NOUN
admet-529	265	10	strategy	strategy	NOUN
admet-529	265	11	illustrating	illustrate	VERB
admet-529	265	12	the	the	DET
admet-529	265	13	suitability	suitability	NOUN
admet-529	265	14	of	of	ADP
admet-529	265	15	epsa	epsa	NOUN
admet-529	265	16	as	as	ADP
admet-529	265	17	a	a	DET
admet-529	265	18	surrogate	surrogate	NOUN
admet-529	265	19	for	for	ADP
admet-529	265	20	cyclic	cyclic	ADJ
admet-529	265	21	peptide	peptide	NOUN
admet-529	265	22	permeability	permeability	NOUN
admet-529	265	23	.	.	PUNCT
admet-529	266	1	while	while	SCONJ
admet-529	266	2	working	work	VERB
admet-529	266	3	towards	towards	ADP
admet-529	266	4	improving	improve	VERB
admet-529	266	5	permeability	permeability	NOUN
admet-529	266	6	of	of	ADP
admet-529	266	7	their	their	PRON
admet-529	266	8	lead	lead	NOUN
admet-529	266	9	compounds	compound	NOUN
admet-529	266	10	,	,	PUNCT
admet-529	266	11	the	the	DET
admet-529	266	12	team	team	NOUN
admet-529	266	13	was	be	AUX
admet-529	266	14	faced	face	VERB
admet-529	266	15	with	with	ADP
admet-529	266	16	a	a	DET
admet-529	266	17	flat	flat	ADJ
admet-529	266	18	structure	structure	NOUN
admet-529	266	19	-	-	PUNCT
admet-529	266	20	permeability	permeability	NOUN
admet-529	266	21	relationship	relationship	NOUN
admet-529	266	22	(	(	PUNCT
admet-529	266	23	no	no	DET
admet-529	266	24	significant	significant	ADJ
admet-529	266	25	improvement	improvement	NOUN
admet-529	266	26	in	in	ADP
admet-529	266	27	permeability	permeability	NOUN
admet-529	266	28	as	as	SCONJ
admet-529	266	29	measured	measure	VERB
admet-529	266	30	by	by	ADP
admet-529	266	31	rrck	rrck	NOUN
admet-529	266	32	cells	cell	NOUN
admet-529	266	33	was	be	AUX
admet-529	266	34	detected	detect	VERB
admet-529	266	35	with	with	ADP
admet-529	266	36	any	any	DET
admet-529	266	37	modification	modification	NOUN
admet-529	266	38	)	)	PUNCT
admet-529	266	39	.	.	PUNCT
admet-529	267	1	since	since	SCONJ
admet-529	267	2	the	the	DET
admet-529	267	3	lead	lead	NOUN
admet-529	267	4	compound	compound	NOUN
admet-529	267	5	had	have	VERB
admet-529	267	6	an	an	DET
admet-529	267	7	epsa	epsa	NOUN
admet-529	267	8	value	value	NOUN
admet-529	267	9	in	in	ADP
admet-529	267	10	the	the	DET
admet-529	267	11	high	high	ADJ
admet-529	267	12	160s	160	NOUN
admet-529	267	13	,	,	PUNCT
admet-529	267	14	reducing	reduce	VERB
admet-529	267	15	measured	measure	VERB
admet-529	267	16	polarity	polarity	NOUN
admet-529	267	17	became	become	VERB
admet-529	267	18	the	the	DET
admet-529	267	19	surrogate	surrogate	ADJ
admet-529	267	20	objective	objective	NOUN
admet-529	267	21	.	.	PUNCT
admet-529	268	1	epsa	epsa	NOUN
admet-529	268	2	measurements	measurement	NOUN
admet-529	268	3	drove	drive	VERB
admet-529	268	4	each	each	DET
admet-529	268	5	new	new	ADJ
admet-529	268	6	design	design	NOUN
admet-529	268	7	.	.	PUNCT
admet-529	269	1	plans	plan	VERB
admet-529	269	2	that	that	PRON
admet-529	269	3	increased	increase	VERB
admet-529	269	4	epsa	epsa	NOUN
admet-529	269	5	were	be	AUX
admet-529	269	6	abandoned	abandon	VERB
admet-529	269	7	in	in	ADP
admet-529	269	8	favor	favor	NOUN
admet-529	269	9	of	of	ADP
admet-529	269	10	those	those	DET
admet-529	269	11	decreasing	decrease	VERB
admet-529	269	12	epsa	epsa	NOUN
admet-529	269	13	.	.	PUNCT
admet-529	270	1	with	with	ADP
admet-529	270	2	each	each	DET
admet-529	270	3	design	design	NOUN
admet-529	270	4	cycle	cycle	NOUN
admet-529	270	5	it	it	PRON
admet-529	270	6	was	be	AUX
admet-529	270	7	observed	observe	VERB
admet-529	270	8	that	that	SCONJ
admet-529	270	9	a	a	DET
admet-529	270	10	gradual	gradual	ADJ
admet-529	270	11	decrease	decrease	NOUN
admet-529	270	12	in	in	ADP
admet-529	270	13	polarity	polarity	NOUN
admet-529	270	14	was	be	AUX
admet-529	270	15	obtained	obtain	VERB
admet-529	270	16	but	but	CCONJ
admet-529	270	17	without	without	ADP
admet-529	270	18	any	any	DET
admet-529	270	19	significant	significant	ADJ
admet-529	270	20	improvement	improvement	NOUN
admet-529	270	21	in	in	ADP
admet-529	270	22	permeability	permeability	NOUN
admet-529	270	23	as	as	SCONJ
admet-529	270	24	measured	measure	VERB
admet-529	270	25	by	by	ADP
admet-529	270	26	rrck	rrck	PROPN
admet-529	270	27	,	,	PUNCT
admet-529	270	28	until	until	SCONJ
admet-529	270	29	a	a	DET
admet-529	270	30	threshold	threshold	NOUN
admet-529	270	31	in	in	ADP
admet-529	270	32	epsa	epsa	NOUN
admet-529	270	33	was	be	AUX
admet-529	270	34	reached	reach	VERB
admet-529	270	35	(	(	PUNCT
admet-529	270	36	epsa	epsa	VERB
admet-529	270	37	<	<	X
admet-529	270	38	100	100	NUM
admet-529	270	39	)	)	PUNCT
admet-529	270	40	upon	upon	SCONJ
admet-529	270	41	which	which	DET
admet-529	270	42	permeability	permeability	NOUN
admet-529	270	43	became	become	VERB
admet-529	270	44	measurable	measurable	ADJ
admet-529	270	45	and	and	CCONJ
admet-529	270	46	increased	increase	VERB
admet-529	270	47	to	to	PART
admet-529	270	48	reach	reach	VERB
admet-529	270	49	acceptable	acceptable	ADJ
admet-529	270	50	levels	level	NOUN
admet-529	270	51	(	(	PUNCT
admet-529	270	52	epsa	epsa	VERB
admet-529	270	53	<	<	X
admet-529	270	54	80	80	NUM
admet-529	270	55	)	)	PUNCT
admet-529	270	56	.	.	PUNCT
admet-529	271	1	at	at	ADP
admet-529	271	2	pfizer	pfizer	NOUN
admet-529	271	3	,	,	PUNCT
admet-529	271	4	and	and	CCONJ
admet-529	271	5	across	across	ADP
admet-529	271	6	multiple	multiple	ADJ
admet-529	271	7	academic	academic	ADJ
admet-529	271	8	collaborations	collaboration	NOUN
admet-529	271	9	[	[	X
admet-529	271	10	38,89	38,89	NUM
admet-529	271	11	-	-	SYM
admet-529	271	12	91	91	NUM
admet-529	271	13	]	]	PUNCT
admet-529	271	14	,	,	PUNCT
admet-529	271	15	project	project	NOUN
admet-529	271	16	teams	team	NOUN
admet-529	271	17	routinely	routinely	ADV
admet-529	271	18	use	use	VERB
admet-529	271	19	epsa	epsa	NOUN
admet-529	271	20	data	datum	NOUN
admet-529	271	21	to	to	PART
admet-529	271	22	inform	inform	VERB
admet-529	271	23	peptide	peptide	ADJ
admet-529	271	24	design	design	NOUN
admet-529	271	25	as	as	ADP
admet-529	271	26	a	a	DET
admet-529	271	27	predictor	predictor	NOUN
admet-529	271	28	of	of	ADP
admet-529	271	29	permeability	permeability	NOUN
admet-529	271	30	and	and	CCONJ
admet-529	271	31	as	as	ADP
admet-529	271	32	an	an	DET
admet-529	271	33	indicator	indicator	NOUN
admet-529	271	34	of	of	ADP
admet-529	271	35	imhb	imhb	ADJ
admet-529	271	36	patterns	pattern	NOUN
admet-529	271	37	in	in	ADP
admet-529	271	38	cyclic	cyclic	ADJ
admet-529	271	39	peptides	peptide	NOUN
admet-529	271	40	.	.	PUNCT
admet-529	272	1	furthermore	furthermore	ADV
admet-529	272	2	,	,	PUNCT
admet-529	272	3	epsa	epsa	NOUN
admet-529	272	4	is	be	AUX
admet-529	272	5	now	now	ADV
admet-529	272	6	used	use	VERB
admet-529	272	7	in	in	ADP
admet-529	272	8	a	a	DET
admet-529	272	9	prospective	prospective	ADJ
admet-529	272	10	way	way	NOUN
admet-529	272	11	after	after	ADP
admet-529	272	12	the	the	DET
admet-529	272	13	development	development	NOUN
admet-529	272	14	of	of	ADP
admet-529	272	15	an	an	DET
admet-529	272	16	in	in	ADP
admet-529	272	17	-	-	PUNCT
admet-529	272	18	house	house	NOUN
admet-529	272	19	computational	computational	ADJ
admet-529	272	20	model	model	NOUN
admet-529	272	21	[	[	X
admet-529	272	22	92	92	NUM
admet-529	272	23	]	]	PUNCT
admet-529	272	24	.	.	PUNCT
admet-529	273	1	it	it	PRON
admet-529	273	2	was	be	AUX
admet-529	273	3	built	build	VERB
admet-529	273	4	using	use	VERB
admet-529	273	5	the	the	DET
admet-529	273	6	following	follow	VERB
admet-529	273	7	procedure	procedure	NOUN
admet-529	273	8	.	.	PUNCT
admet-529	274	1	compounds	compound	NOUN
admet-529	274	2	undergo	undergo	VERB
admet-529	274	3	a	a	DET
admet-529	274	4	thorough	thorough	ADJ
admet-529	274	5	conformational	conformational	ADJ
admet-529	274	6	analysis	analysis	NOUN
admet-529	274	7	(	(	PUNCT
admet-529	274	8	macro	macro	ADJ
admet-529	274	9	model	model	NOUN
admet-529	274	10	)	)	PUNCT
admet-529	274	11	followed	follow	VERB
admet-529	274	12	by	by	ADP
admet-529	274	13	3d	3d	PROPN
admet-529	274	14	descriptors	descriptor	NOUN
admet-529	274	15	calculation	calculation	NOUN
admet-529	274	16	(	(	PUNCT
admet-529	274	17	volsurf+	volsurf+	NOUN
admet-529	274	18	)	)	PUNCT
admet-529	274	19	based	base	VERB
admet-529	274	20	on	on	ADP
admet-529	274	21	molecular	molecular	ADJ
admet-529	274	22	interaction	interaction	NOUN
admet-529	274	23	fields	field	NOUN
admet-529	274	24	(	(	PUNCT
admet-529	274	25	mifs	mifs	PROPN
admet-529	274	26	)	)	PUNCT
admet-529	274	27	.	.	PUNCT
admet-529	275	1	a	a	DET
admet-529	275	2	partial	partial	ADJ
admet-529	275	3	least	least	ADJ
admet-529	275	4	squares	square	NOUN
admet-529	275	5	(	(	PUNCT
admet-529	275	6	pls	pls	INTJ
admet-529	275	7	)	)	PUNCT
admet-529	275	8	regression	regression	NOUN
admet-529	275	9	algorithm	algorithm	NOUN
admet-529	275	10	is	be	AUX
admet-529	275	11	then	then	ADV
admet-529	275	12	used	use	VERB
admet-529	275	13	to	to	PART
admet-529	275	14	establish	establish	VERB
admet-529	275	15	a	a	DET
admet-529	275	16	quantitative	quantitative	ADJ
admet-529	275	17	relationship	relationship	NOUN
admet-529	275	18	between	between	ADP
admet-529	275	19	the	the	DET
admet-529	275	20	matrix	matrix	NOUN
admet-529	275	21	of	of	ADP
admet-529	275	22	descriptors	descriptor	NOUN
admet-529	275	23	and	and	CCONJ
admet-529	275	24	the	the	DET
admet-529	275	25	epsa	epsa	NOUN
admet-529	275	26	endpoint	endpoint	NOUN
admet-529	275	27	.	.	PUNCT
admet-529	276	1	implementation	implementation	NOUN
admet-529	276	2	of	of	ADP
admet-529	276	3	the	the	DET
admet-529	276	4	computational	computational	ADJ
admet-529	276	5	epsa	epsa	NOUN
admet-529	276	6	prediction	prediction	NOUN
admet-529	276	7	model	model	NOUN
admet-529	276	8	,	,	PUNCT
admet-529	276	9	combined	combine	VERB
admet-529	276	10	with	with	ADP
admet-529	276	11	other	other	ADJ
admet-529	276	12	physicochemical	physicochemical	ADJ
admet-529	276	13	properties	property	NOUN
admet-529	276	14	,	,	PUNCT
admet-529	276	15	has	have	AUX
admet-529	276	16	enabled	enable	VERB
admet-529	276	17	virtual	virtual	ADJ
admet-529	276	18	compound	compound	NOUN
admet-529	276	19	design	design	NOUN
admet-529	276	20	,	,	PUNCT
admet-529	276	21	selection	selection	NOUN
admet-529	276	22	of	of	ADP
admet-529	276	23	better	well	ADJ
admet-529	276	24	candidates	candidate	NOUN
admet-529	276	25	for	for	ADP
admet-529	276	26	synthesis	synthesis	NOUN
admet-529	276	27	and	and	CCONJ
admet-529	276	28	has	have	AUX
admet-529	276	29	accelerated	accelerate	VERB
admet-529	276	30	efficiency	efficiency	NOUN
admet-529	276	31	of	of	ADP
admet-529	276	32	design	design	NOUN
admet-529	276	33	cycles	cycle	NOUN
admet-529	276	34	.	.	PUNCT
admet-529	277	1	figure	figure	NOUN
admet-529	277	2	10	10	NUM
admet-529	277	3	.	.	PUNCT
admet-529	278	1	illustration	illustration	NOUN
admet-529	278	2	of	of	ADP
admet-529	278	3	polarity	polarity	NOUN
admet-529	278	4	based	base	VERB
admet-529	278	5	design	design	NOUN
admet-529	278	6	cycle	cycle	NOUN
admet-529	278	7	enabled	enable	VERB
admet-529	278	8	by	by	ADP
admet-529	278	9	the	the	DET
admet-529	278	10	pfizer	pfizer	NOUN
admet-529	278	11	computational	computational	ADJ
admet-529	278	12	epsa	epsa	NOUN
admet-529	278	13	prediction	prediction	NOUN
admet-529	278	14	model	model	NOUN
admet-529	278	15	in	in	ADP
admet-529	278	16	the	the	DET
admet-529	278	17	particular	particular	ADJ
admet-529	278	18	example	example	NOUN
admet-529	278	19	depicted	depict	VERB
admet-529	278	20	in	in	ADP
admet-529	278	21	figure	figure	NOUN
admet-529	278	22	10	10	NUM
admet-529	278	23	,	,	PUNCT
admet-529	278	24	the	the	DET
admet-529	278	25	computational	computational	ADJ
admet-529	278	26	epsa	epsa	NOUN
admet-529	278	27	prediction	prediction	NOUN
admet-529	278	28	model	model	NOUN
admet-529	278	29	was	be	AUX
admet-529	278	30	successfully	successfully	ADV
admet-529	278	31	implemented	implement	VERB
admet-529	278	32	by	by	ADP
admet-529	278	33	the	the	DET
admet-529	278	34	project	project	NOUN
admet-529	278	35	team	team	NOUN
admet-529	278	36	,	,	PUNCT
admet-529	278	37	first	first	ADV
admet-529	278	38	designing	design	VERB
admet-529	278	39	virtual	virtual	ADJ
admet-529	278	40	compound	compound	NOUN
admet-529	278	41	libraries	library	NOUN
admet-529	278	42	,	,	PUNCT
admet-529	278	43	and	and	CCONJ
admet-529	278	44	then	then	ADV
admet-529	278	45	testing	test	VERB
admet-529	278	46	their	their	PRON
admet-529	278	47	epsa	epsa	NOUN
admet-529	278	48	predictions	prediction	NOUN
admet-529	278	49	,	,	PUNCT
admet-529	278	50	as	as	SCONJ
admet-529	278	51	a	a	DET
admet-529	278	52	permeability	permeability	NOUN
admet-529	278	53	surrogate	surrogate	NOUN
admet-529	278	54	.	.	PUNCT
admet-529	279	1	only	only	ADV
admet-529	279	2	compounds	compound	NOUN
admet-529	279	3	with	with	ADP
admet-529	279	4	predicted	predict	VERB
admet-529	279	5	epsa	epsa	NOUN
admet-529	279	6	values	value	NOUN
admet-529	279	7	<	<	X
admet-529	279	8	95	95	NUM
admet-529	279	9	were	be	AUX
admet-529	279	10	prioritized	prioritize	VERB
admet-529	279	11	for	for	ADP
admet-529	279	12	synthesis	synthesis	NOUN
admet-529	279	13	.	.	PUNCT
admet-529	280	1	compounds	compound	NOUN
admet-529	280	2	with	with	ADP
admet-529	280	3	reasonable	reasonable	ADJ
admet-529	280	4	potency	potency	NOUN
admet-529	280	5	and	and	CCONJ
admet-529	280	6	measured	measured	ADJ
admet-529	280	7	epsa	epsa	NOUN
admet-529	280	8	<	<	X
admet-529	280	9	100	100	NUM
admet-529	280	10	were	be	AUX
admet-529	280	11	prioritized	prioritize	VERB
admet-529	280	12	for	for	ADP
admet-529	280	13	cell	cell	NOUN
admet-529	280	14	-	-	PUNCT
admet-529	280	15	based	base	VERB
admet-529	280	16	passive	passive	ADJ
admet-529	280	17	permeability	permeability	NOUN
admet-529	280	18	evaluation	evaluation	NOUN
admet-529	280	19	and	and	CCONJ
admet-529	280	20	hlm	hlm	ADJ
admet-529	280	21	stability	stability	NOUN
admet-529	280	22	assessment	assessment	NOUN
admet-529	280	23	.	.	PUNCT
admet-529	281	1	learnings	learning	NOUN
admet-529	281	2	from	from	ADP
admet-529	281	3	this	this	DET
admet-529	281	4	data	datum	NOUN
admet-529	281	5	the	the	DET
admet-529	281	6	next	next	ADJ
admet-529	281	7	design	design	NOUN
admet-529	281	8	cycle	cycle	NOUN
admet-529	281	9	was	be	AUX
admet-529	281	10	refined	refine	VERB
admet-529	281	11	[	[	PUNCT
admet-529	281	12	93	93	NUM
admet-529	281	13	]	]	PUNCT
admet-529	281	14	.	.	PUNCT
admet-529	282	1	the	the	DET
admet-529	282	2	epsa	epsa	NOUN
admet-529	282	3	technique	technique	NOUN
admet-529	282	4	and	and	CCONJ
admet-529	282	5	its	its	PRON
admet-529	282	6	application	application	NOUN
admet-529	282	7	are	be	AUX
admet-529	282	8	not	not	PART
admet-529	282	9	reserved	reserve	VERB
admet-529	282	10	or	or	CCONJ
admet-529	282	11	limited	limit	VERB
admet-529	282	12	to	to	ADP
admet-529	282	13	pfizer	pfizer	NOUN
admet-529	282	14	and	and	CCONJ
admet-529	282	15	its	its	PRON
admet-529	282	16	collaborators	collaborator	NOUN
admet-529	282	17	,	,	PUNCT
admet-529	282	18	indeed	indeed	ADV
admet-529	282	19	,	,	PUNCT
admet-529	282	20	epsa	epsa	PROPN
admet-529	282	21	has	have	AUX
admet-529	282	22	been	be	AUX
admet-529	282	23	implemented	implement	VERB
admet-529	282	24	across	across	ADP
admet-529	282	25	the	the	DET
admet-529	282	26	pharmaceutical	pharmaceutical	ADJ
admet-529	282	27	industry	industry	NOUN
admet-529	282	28	,	,	PUNCT
admet-529	282	29	i.e.	i.e.	X
admet-529	282	30	at	at	ADP
admet-529	282	31	abbvie	abbvie	NOUN
admet-529	282	32	[	[	X
admet-529	282	33	94	94	NUM
admet-529	282	34	]	]	PUNCT
admet-529	282	35	,	,	PUNCT
admet-529	282	36	novartis	novartis	PROPN
admet-529	283	1	[	[	X
admet-529	283	2	95	95	NUM
admet-529	283	3	]	]	PUNCT
admet-529	283	4	,	,	PUNCT
admet-529	283	5	and	and	CCONJ
admet-529	283	6	merck	merck	PROPN
admet-529	284	1	[	[	X
admet-529	284	2	96	96	NUM
admet-529	284	3	]	]	PUNCT
admet-529	284	4	,	,	PUNCT
admet-529	284	5	epsa	epsa	NOUN
admet-529	284	6	services	service	NOUN
admet-529	284	7	are	be	AUX
admet-529	284	8	available	available	ADJ
admet-529	284	9	through	through	ADP
admet-529	284	10	an	an	DET
admet-529	284	11	established	establish	VERB
admet-529	284	12	analytical	analytical	ADJ
admet-529	284	13	cro	cro	NOUN
admet-529	284	14	[	[	X
admet-529	284	15	97	97	NUM
admet-529	284	16	]	]	PUNCT
admet-529	284	17	.	.	PUNCT
admet-529	285	1	additionally	additionally	ADV
admet-529	285	2	,	,	PUNCT
admet-529	285	3	peter	peter	PROPN
admet-529	285	4	wipf	wipf	VERB
admet-529	285	5	in	in	ADP
admet-529	285	6	his	his	PRON
admet-529	285	7	january	january	PROPN
admet-529	285	8	2017	2017	NUM
admet-529	285	9	editorial	editorial	NOUN
admet-529	285	10	[	[	X
admet-529	285	11	98	98	NUM
admet-529	285	12	]	]	SYM
admet-529	285	13	selected	select	VERB
admet-529	285	14	epsa	epsa	NOUN
admet-529	285	15	as	as	ADP
admet-529	285	16	one	one	NUM
admet-529	285	17	of	of	ADP
admet-529	285	18	the	the	DET
admet-529	285	19	6	6	NUM
admet-529	285	20	technical	technical	ADJ
admet-529	285	21	innovations	innovation	NOUN
admet-529	285	22	published	publish	VERB
admet-529	285	23	in	in	ADP
admet-529	285	24	acs	acs	PROPN
admet-529	285	25	medicinal	medicinal	ADJ
admet-529	285	26	chemistry	chemistry	NOUN
admet-529	285	27	letters	letter	NOUN
admet-529	285	28	over	over	ADP
admet-529	285	29	the	the	DET
admet-529	285	30	past	past	ADJ
admet-529	285	31	3	3	NUM
admet-529	285	32	years	year	NOUN
admet-529	285	33	that	that	PRON
admet-529	285	34	facilitate	facilitate	VERB
admet-529	285	35	the	the	DET
admet-529	285	36	practice	practice	NOUN
admet-529	285	37	of	of	ADP
admet-529	285	38	medicinal	medicinal	ADJ
admet-529	285	39	chemistry	chemistry	NOUN
admet-529	285	40	and	and	CCONJ
admet-529	285	41	are	be	AUX
admet-529	285	42	likely	likely	ADJ
admet-529	285	43	to	to	PART
admet-529	285	44	become	become	VERB
admet-529	285	45	essential	essential	ADJ
admet-529	285	46	items	item	NOUN
admet-529	285	47	in	in	ADP
admet-529	285	48	the	the	DET
admet-529	285	49	medicinal	medicinal	ADJ
admet-529	285	50	chemist	chemist	NOUN
admet-529	285	51	’s	’s	PART
admet-529	285	52	toolbox	toolbox	NOUN
admet-529	285	53	.	.	PUNCT
admet-529	286	1	g.h	g.h	PROPN
admet-529	286	2	.	.	PROPN
admet-529	287	1	goetz	goetz	PROPN
admet-529	287	2	and	and	CCONJ
admet-529	287	3	m.	m.	NOUN
admet-529	287	4	shalaeva	shalaeva	PROPN
admet-529	287	5	admet	admet	PROPN
admet-529	287	6	&	&	CCONJ
admet-529	287	7	dmpk	dmpk	PROPN
admet-529	287	8	6(2	6(2	NUM
admet-529	287	9	)	)	PUNCT
admet-529	287	10	(	(	PUNCT
admet-529	287	11	2018	2018	NUM
admet-529	287	12	)	)	PUNCT
admet-529	287	13	85	85	NUM
admet-529	287	14	-	-	SYM
admet-529	287	15	104	104	NUM
admet-529	287	16	98	98	NUM
admet-529	287	17	conclusions	conclusion	NOUN
admet-529	287	18	across	across	ADP
admet-529	287	19	the	the	DET
admet-529	287	20	pharmaceutical	pharmaceutical	ADJ
admet-529	287	21	industry	industry	NOUN
admet-529	287	22	,	,	PUNCT
admet-529	287	23	each	each	DET
admet-529	287	24	r&d	r&d	NOUN
admet-529	287	25	department	department	NOUN
admet-529	287	26	has	have	VERB
admet-529	287	27	its	its	PRON
admet-529	287	28	own	own	ADJ
admet-529	287	29	philosophy	philosophy	NOUN
admet-529	287	30	.	.	PUNCT
admet-529	288	1	based	base	VERB
admet-529	288	2	on	on	ADP
admet-529	288	3	historical	historical	ADJ
admet-529	288	4	approaches	approach	NOUN
admet-529	288	5	,	,	PUNCT
admet-529	288	6	resource	resource	NOUN
admet-529	288	7	allocations	allocation	NOUN
admet-529	288	8	and	and	CCONJ
admet-529	288	9	leadership	leadership	NOUN
admet-529	288	10	advocacy	advocacy	NOUN
admet-529	288	11	,	,	PUNCT
admet-529	288	12	drug	drug	NOUN
admet-529	288	13	design	design	NOUN
admet-529	288	14	strategies	strategy	NOUN
admet-529	288	15	essentially	essentially	ADV
admet-529	288	16	follow	follow	VERB
admet-529	288	17	the	the	DET
admet-529	288	18	same	same	ADJ
admet-529	288	19	guidelines	guideline	NOUN
admet-529	288	20	with	with	ADP
admet-529	288	21	regards	regard	NOUN
admet-529	288	22	to	to	PART
admet-529	288	23	lead	lead	VERB
admet-529	288	24	optimization	optimization	NOUN
admet-529	288	25	:	:	PUNCT
admet-529	288	26	exquisite	exquisite	ADJ
admet-529	288	27	potency	potency	NOUN
admet-529	288	28	along	along	ADP
admet-529	288	29	with	with	ADP
admet-529	288	30	favorable	favorable	ADJ
admet-529	288	31	admet	admet	NOUN
admet-529	288	32	profiles	profile	NOUN
admet-529	288	33	in	in	ADP
admet-529	288	34	the	the	DET
admet-529	288	35	least	least	ADJ
admet-529	288	36	amount	amount	NOUN
admet-529	288	37	of	of	ADP
admet-529	288	38	time	time	NOUN
admet-529	288	39	and	and	CCONJ
admet-529	288	40	at	at	ADP
admet-529	288	41	the	the	DET
admet-529	288	42	lowest	low	ADJ
admet-529	288	43	possible	possible	ADJ
admet-529	288	44	cost	cost	NOUN
admet-529	288	45	.	.	PUNCT
admet-529	289	1	guiding	guide	VERB
admet-529	289	2	those	those	DET
admet-529	289	3	design	design	NOUN
admet-529	289	4	strategies	strategy	NOUN
admet-529	289	5	through	through	ADP
admet-529	289	6	chromatography	chromatography	NOUN
admet-529	289	7	based	base	VERB
admet-529	289	8	physicochemical	physicochemical	ADJ
admet-529	289	9	properties	property	NOUN
admet-529	289	10	(	(	PUNCT
admet-529	289	11	i.e.	i.e.	X
admet-529	289	12	elog	elog	NOUN
admet-529	289	13	d	d	NOUN
admet-529	289	14	and	and	CCONJ
admet-529	289	15	epsa	epsa	NOUN
admet-529	289	16	)	)	PUNCT
admet-529	289	17	is	be	AUX
admet-529	289	18	one	one	NUM
admet-529	289	19	of	of	ADP
admet-529	289	20	the	the	DET
admet-529	289	21	more	more	ADV
admet-529	289	22	successful	successful	ADJ
admet-529	289	23	approaches	approach	NOUN
admet-529	289	24	developed	develop	VERB
admet-529	289	25	in	in	ADP
admet-529	289	26	order	order	NOUN
admet-529	289	27	to	to	PART
admet-529	289	28	accelerate	accelerate	VERB
admet-529	289	29	the	the	DET
admet-529	289	30	process	process	NOUN
admet-529	289	31	.	.	PUNCT
admet-529	290	1	acknowledgements	acknowledgement	NOUN
admet-529	290	2	:	:	PUNCT
admet-529	290	3	laurence	laurence	PROPN
admet-529	290	4	philippe	philippe	PROPN
admet-529	290	5	for	for	ADP
admet-529	290	6	her	her	PRON
admet-529	290	7	continuous	continuous	ADJ
admet-529	290	8	support	support	NOUN
admet-529	290	9	and	and	CCONJ
admet-529	290	10	mentorship	mentorship	NOUN
admet-529	290	11	,	,	PUNCT
admet-529	290	12	patrick	patrick	PROPN
admet-529	290	13	mullins	mullins	PROPN
admet-529	290	14	and	and	CCONJ
admet-529	290	15	jason	jason	PROPN
admet-529	290	16	ramsay	ramsay	PROPN
admet-529	290	17	for	for	ADP
admet-529	290	18	critical	critical	ADJ
admet-529	290	19	editing	editing	NOUN
admet-529	290	20	and	and	CCONJ
admet-529	290	21	justin	justin	PROPN
admet-529	290	22	montgommery	montgommery	PROPN
admet-529	290	23	for	for	ADP
admet-529	290	24	figures	figure	NOUN
admet-529	290	25	6	6	NUM
admet-529	290	26	and	and	CCONJ
admet-529	290	27	7	7	NUM
admet-529	290	28	.	.	NUM
admet-529	290	29	references	reference	NOUN
admet-529	290	30	[	[	X
admet-529	290	31	1	1	X
admet-529	290	32	]	]	PUNCT
admet-529	290	33	t.	t.	PROPN
admet-529	290	34	kennedy	kennedy	PROPN
admet-529	290	35	.	.	PUNCT
admet-529	291	1	managing	manage	VERB
admet-529	291	2	the	the	DET
admet-529	291	3	drug	drug	NOUN
admet-529	291	4	discovery	discovery	NOUN
admet-529	291	5	/	/	SYM
admet-529	291	6	development	development	NOUN
admet-529	291	7	interface	interface	NOUN
admet-529	291	8	.	.	PUNCT
admet-529	292	1	drug	drug	NOUN
admet-529	292	2	discov	discov	PROPN
admet-529	292	3	today	today	NOUN
admet-529	292	4	2	2	NUM
admet-529	292	5	(	(	PUNCT
admet-529	292	6	1997	1997	NUM
admet-529	292	7	)	)	PUNCT
admet-529	292	8	436444	436444	NUM
admet-529	292	9	.	.	PUNCT
admet-529	293	1	[	[	X
admet-529	293	2	2	2	NUM
admet-529	293	3	]	]	PUNCT
admet-529	293	4	a.d.w	a.d.w	NOUN
admet-529	293	5	.	.	PUNCT
admet-529	293	6	mcnaught	mcnaught	PROPN
admet-529	293	7	,	,	PUNCT
admet-529	293	8	m.	m.	PROPN
admet-529	293	9	nic	nic	PROPN
admet-529	293	10	,	,	PUNCT
admet-529	293	11	j.	j.	PROPN
admet-529	293	12	jirat	jirat	PROPN
admet-529	293	13	,	,	PUNCT
admet-529	293	14	b.	b.	PROPN
admet-529	293	15	kosata	kosata	PROPN
admet-529	293	16	,	,	PUNCT
admet-529	293	17	a.	a.	PROPN
admet-529	293	18	jenkins	jenkins	PROPN
admet-529	293	19	.	.	PUNCT
admet-529	294	1	iupac	iupac	PROPN
admet-529	294	2	.	.	PUNCT
admet-529	295	1	compendium	compendium	NOUN
admet-529	295	2	of	of	ADP
admet-529	295	3	chemical	chemical	NOUN
admet-529	295	4	terminology	terminology	NOUN
admet-529	295	5	,	,	PUNCT
admet-529	295	6	2nd	2nd	ADJ
admet-529	295	7	ed	ed	NOUN
admet-529	295	8	.	.	PUNCT
admet-529	296	1	iupac	iupac	PROPN
admet-529	296	2	the	the	DET
admet-529	296	3	"	"	PUNCT
admet-529	296	4	gold	gold	NOUN
admet-529	296	5	book	book	NOUN
admet-529	296	6	"	"	PUNCT
admet-529	296	7	,	,	PUNCT
admet-529	296	8	blackwell	blackwell	ADJ
admet-529	296	9	scientific	scientific	ADJ
admet-529	296	10	publications	publication	NOUN
admet-529	296	11	,	,	PUNCT
admet-529	296	12	oxford	oxford	PROPN
admet-529	296	13	2006	2006	NUM
admet-529	296	14	.	.	PUNCT
admet-529	297	1	[	[	X
admet-529	297	2	3	3	NUM
admet-529	297	3	]	]	X
admet-529	297	4	m.j	m.j	PROPN
admet-529	297	5	.	.	PROPN
admet-529	297	6	waring	waring	NOUN
admet-529	297	7	.	.	PUNCT
admet-529	298	1	lipophilicity	lipophilicity	NOUN
admet-529	298	2	in	in	ADP
admet-529	298	3	drug	drug	NOUN
admet-529	298	4	discovery	discovery	NOUN
admet-529	298	5	.	.	PUNCT
admet-529	299	1	expert	expert	ADJ
admet-529	299	2	opinion	opinion	NOUN
admet-529	299	3	on	on	ADP
admet-529	299	4	drug	drug	NOUN
admet-529	299	5	discovery	discovery	NOUN
admet-529	299	6	5	5	NUM
admet-529	299	7	(	(	PUNCT
admet-529	299	8	2010	2010	NUM
admet-529	299	9	)	)	PUNCT
admet-529	299	10	235	235	NUM
admet-529	299	11	-	-	SYM
admet-529	299	12	248	248	NUM
admet-529	299	13	.	.	PUNCT
admet-529	300	1	[	[	X
admet-529	300	2	4	4	NUM
admet-529	300	3	]	]	X
admet-529	300	4	r.	r.	PROPN
admet-529	300	5	mannhold	mannhold	PROPN
admet-529	300	6	,	,	PUNCT
admet-529	300	7	g.i	g.i	PROPN
admet-529	300	8	.	.	PROPN
admet-529	300	9	poda	poda	PROPN
admet-529	300	10	,	,	PUNCT
admet-529	300	11	c.	c.	PROPN
admet-529	300	12	ostermann	ostermann	PROPN
admet-529	300	13	,	,	PUNCT
admet-529	300	14	i.v	i.v	PROPN
admet-529	300	15	.	.	PUNCT
admet-529	300	16	tetko	tetko	PROPN
admet-529	300	17	.	.	PUNCT
admet-529	301	1	calculation	calculation	NOUN
admet-529	301	2	of	of	ADP
admet-529	301	3	molecular	molecular	ADJ
admet-529	301	4	lipophilicity	lipophilicity	NOUN
admet-529	301	5	:	:	PUNCT
admet-529	301	6	state	state	NOUN
admet-529	301	7	-	-	PUNCT
admet-529	301	8	ofthe	ofthe	NOUN
admet-529	301	9	-	-	PUNCT
admet-529	301	10	art	art	NOUN
admet-529	301	11	and	and	CCONJ
admet-529	301	12	comparison	comparison	NOUN
admet-529	301	13	of	of	ADP
admet-529	301	14	log	log	NOUN
admet-529	301	15	p	p	NOUN
admet-529	301	16	methods	method	NOUN
admet-529	301	17	on	on	ADP
admet-529	301	18	more	more	ADJ
admet-529	301	19	than	than	ADP
admet-529	301	20	96,000	96,000	NUM
admet-529	301	21	compounds	compound	NOUN
admet-529	301	22	.	.	PUNCT
admet-529	302	1	j	j	PROPN
admet-529	302	2	pharm	pharm	PROPN
admet-529	302	3	sci	sci	PROPN
admet-529	302	4	98	98	NUM
admet-529	302	5	(	(	PUNCT
admet-529	302	6	2009	2009	NUM
admet-529	302	7	)	)	PUNCT
admet-529	302	8	861	861	NUM
admet-529	302	9	-	-	SYM
admet-529	302	10	893	893	NUM
admet-529	302	11	.	.	PUNCT
admet-529	303	1	[	[	X
admet-529	303	2	5	5	X
admet-529	303	3	]	]	PUNCT
admet-529	303	4	k.	k.	NOUN
admet-529	303	5	valkó	valkó	PROPN
admet-529	303	6	,	,	PUNCT
admet-529	303	7	c.	c.	PROPN
admet-529	303	8	bevan	bevan	PROPN
admet-529	303	9	,	,	PUNCT
admet-529	303	10	d.	d.	PROPN
admet-529	303	11	reynolds	reynolds	PROPN
admet-529	303	12	.	.	PUNCT
admet-529	304	1	chromatographic	chromatographic	ADJ
admet-529	304	2	hydrophobicity	hydrophobicity	NOUN
admet-529	304	3	index	index	NOUN
admet-529	304	4	by	by	ADP
admet-529	304	5	fast	fast	ADJ
admet-529	304	6	-	-	PUNCT
admet-529	304	7	gradient	gradient	NOUN
admet-529	304	8	rp	rp	NOUN
admet-529	304	9	-	-	PUNCT
admet-529	304	10	hplc	hplc	NOUN
admet-529	304	11	:	:	PUNCT
admet-529	304	12	a	a	DET
admet-529	304	13	high	high	ADJ
admet-529	304	14	-	-	PUNCT
admet-529	304	15	throughput	throughput	NOUN
admet-529	304	16	alternative	alternative	NOUN
admet-529	304	17	to	to	PART
admet-529	304	18	log	log	VERB
admet-529	304	19	p	p	NOUN
admet-529	304	20	/	/	SYM
admet-529	304	21	log	log	NOUN
admet-529	304	22	d.	d.	PROPN
admet-529	304	23	analytical	analytical	ADJ
admet-529	304	24	chemistry	chemistry	NOUN
admet-529	304	25	69	69	NUM
admet-529	304	26	(	(	PUNCT
admet-529	304	27	1997	1997	NUM
admet-529	304	28	)	)	PUNCT
admet-529	304	29	2022	2022	NUM
admet-529	304	30	-	-	SYM
admet-529	304	31	2029	2029	NUM
admet-529	304	32	.	.	PUNCT
admet-529	305	1	[	[	X
admet-529	305	2	6	6	NUM
admet-529	305	3	]	]	PUNCT
admet-529	305	4	f.	f.	PROPN
admet-529	305	5	lombardo	lombardo	PROPN
admet-529	305	6	,	,	PUNCT
admet-529	305	7	m.y	m.y	PROPN
admet-529	305	8	.	.	PROPN
admet-529	305	9	shalaeva	shalaeva	PROPN
admet-529	305	10	,	,	PUNCT
admet-529	305	11	k.a	k.a	PROPN
admet-529	305	12	.	.	PROPN
admet-529	305	13	tupper	tupper	PROPN
admet-529	305	14	,	,	PUNCT
admet-529	305	15	f.	f.	PROPN
admet-529	305	16	gao	gao	PROPN
admet-529	305	17	.	.	PUNCT
admet-529	306	1	elogdoct	elogdoct	PROPN
admet-529	306	2	:	:	PUNCT
admet-529	306	3	a	a	DET
admet-529	306	4	tool	tool	NOUN
admet-529	306	5	for	for	ADP
admet-529	306	6	lipophilicity	lipophilicity	NOUN
admet-529	306	7	determination	determination	NOUN
admet-529	306	8	in	in	ADP
admet-529	306	9	drug	drug	NOUN
admet-529	306	10	discovery	discovery	NOUN
admet-529	306	11	.	.	PUNCT
admet-529	307	1	2	2	X
admet-529	307	2	.	.	NUM
admet-529	307	3	basic	basic	ADJ
admet-529	307	4	and	and	CCONJ
admet-529	307	5	neutral	neutral	ADJ
admet-529	307	6	compounds	compound	NOUN
admet-529	307	7	.	.	PUNCT
admet-529	308	1	journal	journal	NOUN
admet-529	308	2	of	of	ADP
admet-529	308	3	medicinal	medicinal	ADJ
admet-529	308	4	chemistry	chemistry	NOUN
admet-529	308	5	44	44	NUM
admet-529	308	6	(	(	PUNCT
admet-529	308	7	2001	2001	NUM
admet-529	308	8	)	)	PUNCT
admet-529	308	9	24902497	24902497	NUM
admet-529	308	10	.	.	PUNCT
admet-529	309	1	[	[	X
admet-529	309	2	7	7	NUM
admet-529	309	3	]	]	X
admet-529	309	4	c.a	c.a	PROPN
admet-529	309	5	.	.	PROPN
admet-529	309	6	lipinski	lipinski	PROPN
admet-529	309	7	,	,	PUNCT
admet-529	309	8	f.	f.	PROPN
admet-529	309	9	lombardo	lombardo	PROPN
admet-529	309	10	,	,	PUNCT
admet-529	309	11	b.w	b.w	PROPN
admet-529	309	12	.	.	PROPN
admet-529	309	13	dominy	dominy	PROPN
admet-529	309	14	,	,	PUNCT
admet-529	309	15	p.j	p.j	PROPN
admet-529	309	16	.	.	PROPN
admet-529	309	17	feeney	feeney	PROPN
admet-529	309	18	.	.	PUNCT
admet-529	310	1	experimental	experimental	ADJ
admet-529	310	2	and	and	CCONJ
admet-529	310	3	computational	computational	ADJ
admet-529	310	4	approaches	approach	NOUN
admet-529	310	5	to	to	PART
admet-529	310	6	estimate	estimate	VERB
admet-529	310	7	solubility	solubility	NOUN
admet-529	310	8	and	and	CCONJ
admet-529	310	9	permeability	permeability	NOUN
admet-529	310	10	in	in	ADP
admet-529	310	11	drug	drug	NOUN
admet-529	310	12	discovery	discovery	NOUN
admet-529	310	13	and	and	CCONJ
admet-529	310	14	development	development	NOUN
admet-529	310	15	settings1pii	settings1pii	NOUN
admet-529	310	16	of	of	ADP
admet-529	310	17	original	original	ADJ
admet-529	310	18	article	article	NOUN
admet-529	310	19	:	:	PUNCT
admet-529	310	20	s0169	s0169	PROPN
admet-529	310	21	-	-	PUNCT
admet-529	310	22	409x(96)00423	409x(96)00423	NUM
admet-529	310	23	-	-	PUNCT
admet-529	310	24	1	1	NUM
admet-529	310	25	.	.	PUNCT
admet-529	311	1	the	the	DET
admet-529	311	2	article	article	NOUN
admet-529	311	3	was	be	AUX
admet-529	311	4	originally	originally	ADV
admet-529	311	5	published	publish	VERB
admet-529	311	6	in	in	ADP
admet-529	311	7	advanced	advanced	ADJ
admet-529	311	8	drug	drug	NOUN
admet-529	311	9	delivery	delivery	NOUN
admet-529	311	10	reviews	review	VERB
admet-529	311	11	23	23	NUM
admet-529	311	12	(	(	PUNCT
admet-529	311	13	1997	1997	NUM
admet-529	311	14	)	)	PUNCT
admet-529	311	15	3–25.1	3–25.1	NUM
admet-529	311	16	.	.	PUNCT
admet-529	312	1	advanced	advanced	ADJ
admet-529	312	2	drug	drug	NOUN
admet-529	312	3	delivery	delivery	NOUN
admet-529	312	4	reviews	review	VERB
admet-529	312	5	46	46	NUM
admet-529	312	6	(	(	PUNCT
admet-529	312	7	2001	2001	NUM
admet-529	312	8	)	)	PUNCT
admet-529	312	9	3	3	NUM
admet-529	312	10	-	-	SYM
admet-529	312	11	26	26	NUM
admet-529	312	12	.	.	PUNCT
admet-529	313	1	[	[	X
admet-529	313	2	8	8	NUM
admet-529	313	3	]	]	X
admet-529	313	4	a.l	a.l	PROPN
admet-529	313	5	.	.	PROPN
admet-529	313	6	hopkins	hopkins	PROPN
admet-529	313	7	,	,	PUNCT
admet-529	313	8	c.r	c.r	PROPN
admet-529	313	9	.	.	PROPN
admet-529	313	10	groom	groom	PROPN
admet-529	313	11	,	,	PUNCT
admet-529	313	12	a.	a.	PROPN
admet-529	313	13	alex	alex	PROPN
admet-529	313	14	.	.	PROPN
admet-529	313	15	ligand	ligand	PROPN
admet-529	313	16	efficiency	efficiency	NOUN
admet-529	313	17	:	:	PUNCT
admet-529	313	18	a	a	DET
admet-529	313	19	useful	useful	ADJ
admet-529	313	20	metric	metric	NOUN
admet-529	313	21	for	for	ADP
admet-529	313	22	lead	lead	ADJ
admet-529	313	23	selection	selection	NOUN
admet-529	313	24	.	.	PUNCT
admet-529	314	1	drug	drug	NOUN
admet-529	314	2	discov	discov	PROPN
admet-529	314	3	today	today	NOUN
admet-529	314	4	9	9	NUM
admet-529	314	5	(	(	PUNCT
admet-529	314	6	2004	2004	NUM
admet-529	314	7	)	)	PUNCT
admet-529	314	8	430	430	NUM
admet-529	314	9	-	-	SYM
admet-529	314	10	431	431	NUM
admet-529	314	11	.	.	PUNCT
admet-529	315	1	[	[	X
admet-529	315	2	9	9	NUM
admet-529	315	3	]	]	X
admet-529	315	4	p.d	p.d	PROPN
admet-529	315	5	.	.	PROPN
admet-529	315	6	leeson	leeson	PROPN
admet-529	315	7	,	,	PUNCT
admet-529	315	8	b.	b.	PROPN
admet-529	315	9	springthorpe	springthorpe	PROPN
admet-529	315	10	.	.	PUNCT
admet-529	316	1	the	the	DET
admet-529	316	2	influence	influence	NOUN
admet-529	316	3	of	of	ADP
admet-529	316	4	drug	drug	NOUN
admet-529	316	5	-	-	PUNCT
admet-529	316	6	like	like	ADJ
admet-529	316	7	concepts	concept	NOUN
admet-529	316	8	on	on	ADP
admet-529	316	9	decision	decision	NOUN
admet-529	316	10	-	-	PUNCT
admet-529	316	11	making	making	NOUN
admet-529	316	12	in	in	ADP
admet-529	316	13	medicinal	medicinal	ADJ
admet-529	316	14	chemistry	chemistry	NOUN
admet-529	316	15	.	.	PUNCT
admet-529	317	1	nat	nat	PROPN
admet-529	317	2	rev	rev	PROPN
admet-529	317	3	drug	drug	PROPN
admet-529	317	4	discov	discov	PROPN
admet-529	317	5	6	6	NUM
admet-529	317	6	(	(	PUNCT
admet-529	317	7	2007	2007	NUM
admet-529	317	8	)	)	PUNCT
admet-529	317	9	881	881	NUM
admet-529	317	10	-	-	SYM
admet-529	317	11	890	890	NUM
admet-529	317	12	.	.	PUNCT
admet-529	318	1	[	[	X
admet-529	318	2	10	10	NUM
admet-529	318	3	]	]	PUNCT
admet-529	318	4	t.	t.	NOUN
admet-529	318	5	ryckmans	ryckmans	PROPN
admet-529	318	6	,	,	PUNCT
admet-529	318	7	m.p	m.p	PROPN
admet-529	318	8	.	.	PROPN
admet-529	318	9	edwards	edwards	PROPN
admet-529	318	10	,	,	PUNCT
admet-529	318	11	v.a	v.a	PROPN
admet-529	318	12	.	.	PROPN
admet-529	318	13	horne	horne	PROPN
admet-529	318	14	,	,	PUNCT
admet-529	318	15	a.m.	a.m.	PROPN
admet-529	318	16	correia	correia	PROPN
admet-529	318	17	,	,	PUNCT
admet-529	318	18	d.r	d.r	PROPN
admet-529	318	19	.	.	PROPN
admet-529	318	20	owen	owen	PROPN
admet-529	318	21	,	,	PUNCT
admet-529	318	22	l.r	l.r	PROPN
admet-529	318	23	.	.	PROPN
admet-529	318	24	thompson	thompson	PROPN
admet-529	318	25	,	,	PUNCT
admet-529	318	26	i.	i.	PROPN
admet-529	318	27	tran	tran	PROPN
admet-529	318	28	,	,	PUNCT
admet-529	318	29	m.f	m.f	PROPN
admet-529	318	30	.	.	PROPN
admet-529	318	31	tutt	tutt	PROPN
admet-529	318	32	,	,	PUNCT
admet-529	318	33	t.	t.	PROPN
admet-529	318	34	young	young	PROPN
admet-529	318	35	.	.	PUNCT
admet-529	319	1	rapid	rapid	ADJ
admet-529	319	2	assessment	assessment	NOUN
admet-529	319	3	of	of	ADP
admet-529	319	4	a	a	DET
admet-529	319	5	novel	novel	ADJ
admet-529	319	6	series	series	NOUN
admet-529	319	7	of	of	ADP
admet-529	319	8	selective	selective	ADJ
admet-529	319	9	cb(2	cb(2	PROPN
admet-529	319	10	)	)	PUNCT
admet-529	319	11	agonists	agonist	NOUN
admet-529	319	12	using	use	VERB
admet-529	319	13	parallel	parallel	ADJ
admet-529	319	14	synthesis	synthesis	NOUN
admet-529	319	15	protocols	protocol	NOUN
admet-529	319	16	:	:	PUNCT
admet-529	319	17	a	a	DET
admet-529	319	18	lipophilic	lipophilic	ADJ
admet-529	319	19	efficiency	efficiency	NOUN
admet-529	319	20	(	(	PUNCT
admet-529	319	21	lipe	lipe	PROPN
admet-529	319	22	)	)	PUNCT
admet-529	319	23	analysis	analysis	NOUN
admet-529	319	24	.	.	PUNCT
admet-529	320	1	bioorg	bioorg	PROPN
admet-529	320	2	med	med	PROPN
admet-529	320	3	chem	chem	NOUN
admet-529	320	4	lett	lett	NOUN
admet-529	320	5	19	19	NUM
admet-529	320	6	(	(	PUNCT
admet-529	320	7	2009	2009	NUM
admet-529	320	8	)	)	PUNCT
admet-529	320	9	4406	4406	NUM
admet-529	320	10	-	-	SYM
admet-529	320	11	4409	4409	NUM
admet-529	320	12	.	.	PUNCT
admet-529	321	1	[	[	X
admet-529	321	2	11	11	NUM
admet-529	321	3	]	]	X
admet-529	321	4	a.f	a.f	PROPN
admet-529	321	5	.	.	PROPN
admet-529	321	6	stepan	stepan	PROPN
admet-529	321	7	,	,	PUNCT
admet-529	321	8	g.w	g.w	PROPN
admet-529	321	9	.	.	PROPN
admet-529	321	10	kauffman	kauffman	PROPN
admet-529	321	11	,	,	PUNCT
admet-529	321	12	c.e	c.e	PROPN
admet-529	321	13	.	.	PROPN
admet-529	321	14	keefer	keefer	PROPN
admet-529	321	15	,	,	PUNCT
admet-529	321	16	p.r	p.r	PROPN
admet-529	321	17	.	.	PROPN
admet-529	321	18	verhoest	verhoest	PROPN
admet-529	321	19	,	,	PUNCT
admet-529	321	20	m.	m.	NOUN
admet-529	321	21	edwards	edwards	PROPN
admet-529	321	22	.	.	PUNCT
admet-529	322	1	evaluating	evaluate	VERB
admet-529	322	2	the	the	DET
admet-529	322	3	differences	difference	NOUN
admet-529	322	4	in	in	ADP
admet-529	322	5	cycloalkyl	cycloalkyl	ADJ
admet-529	322	6	ether	ether	NOUN
admet-529	322	7	metabolism	metabolism	NOUN
admet-529	322	8	using	use	VERB
admet-529	322	9	the	the	DET
admet-529	322	10	design	design	NOUN
admet-529	322	11	parameter	parameter	NOUN
admet-529	322	12	“	"	PUNCT
admet-529	322	13	lipophilic	lipophilic	ADJ
admet-529	322	14	metabolism	metabolism	NOUN
admet-529	322	15	efficiency	efficiency	NOUN
admet-529	322	16	”	"	PUNCT
admet-529	322	17	(	(	PUNCT
admet-529	322	18	lipmete	lipmete	NOUN
admet-529	322	19	)	)	PUNCT
admet-529	322	20	and	and	CCONJ
admet-529	322	21	a	a	DET
admet-529	322	22	matched	match	VERB
admet-529	322	23	molecular	molecular	ADJ
admet-529	322	24	pairs	pair	NOUN
admet-529	322	25	analysis	analysis	NOUN
admet-529	322	26	.	.	PUNCT
admet-529	323	1	journal	journal	NOUN
admet-529	323	2	of	of	ADP
admet-529	323	3	medicinal	medicinal	ADJ
admet-529	323	4	chemistry	chemistry	NOUN
admet-529	323	5	56	56	NUM
admet-529	323	6	(	(	PUNCT
admet-529	323	7	2013	2013	NUM
admet-529	323	8	)	)	PUNCT
admet-529	323	9	69856990	69856990	NUM
admet-529	323	10	.	.	PUNCT
admet-529	324	1	[	[	X
admet-529	324	2	12	12	NUM
admet-529	324	3	]	]	X
admet-529	324	4	t.t	t.t	PROPN
admet-529	324	5	.	.	PROPN
admet-529	324	6	wager	wager	PROPN
admet-529	324	7	,	,	PUNCT
admet-529	324	8	x.	x.	PROPN
admet-529	324	9	hou	hou	PROPN
admet-529	324	10	,	,	PUNCT
admet-529	324	11	p.r	p.r	PROPN
admet-529	324	12	.	.	PROPN
admet-529	324	13	verhoest	verhoest	PROPN
admet-529	324	14	,	,	PUNCT
admet-529	324	15	a.	a.	PROPN
admet-529	324	16	villalobos	villalobos	PROPN
admet-529	324	17	.	.	PUNCT
admet-529	325	1	moving	move	VERB
admet-529	325	2	beyond	beyond	ADP
admet-529	325	3	rules	rule	NOUN
admet-529	325	4	:	:	PUNCT
admet-529	325	5	the	the	DET
admet-529	325	6	development	development	NOUN
admet-529	325	7	of	of	ADP
admet-529	325	8	a	a	DET
admet-529	325	9	central	central	ADJ
admet-529	325	10	nervous	nervous	ADJ
admet-529	325	11	system	system	NOUN
admet-529	325	12	multiparameter	multiparameter	NOUN
admet-529	325	13	optimization	optimization	NOUN
admet-529	325	14	(	(	PUNCT
admet-529	325	15	cns	cns	PROPN
admet-529	325	16	mpo	mpo	PROPN
admet-529	325	17	)	)	PUNCT
admet-529	325	18	approach	approach	NOUN
admet-529	325	19	to	to	PART
admet-529	325	20	enable	enable	VERB
admet-529	325	21	alignment	alignment	NOUN
admet-529	325	22	of	of	ADP
admet-529	325	23	druglike	druglike	NOUN
admet-529	325	24	properties	property	NOUN
admet-529	325	25	.	.	PUNCT
admet-529	326	1	acs	acs	PROPN
admet-529	326	2	chemical	chemical	PROPN
admet-529	326	3	neuroscience	neuroscience	NOUN
admet-529	326	4	1	1	NUM
admet-529	326	5	(	(	PUNCT
admet-529	326	6	2010	2010	NUM
admet-529	326	7	)	)	PUNCT
admet-529	326	8	435	435	NUM
admet-529	326	9	-	-	SYM
admet-529	326	10	449	449	NUM
admet-529	326	11	.	.	PUNCT
admet-529	327	1	[	[	X
admet-529	327	2	13	13	NUM
admet-529	327	3	]	]	X
admet-529	327	4	m.m	m.m	PROPN
admet-529	327	5	.	.	PROPN
admet-529	327	6	claffey	claffey	PROPN
admet-529	327	7	,	,	PUNCT
admet-529	327	8	c.j	c.j	PROPN
admet-529	327	9	.	.	PROPN
admet-529	327	10	helal	helal	PROPN
admet-529	327	11	,	,	PUNCT
admet-529	327	12	p.r	p.r	PROPN
admet-529	327	13	.	.	PROPN
admet-529	327	14	verhoest	verhoest	PROPN
admet-529	327	15	,	,	PUNCT
admet-529	327	16	z.	z.	PROPN
admet-529	327	17	kang	kang	PROPN
admet-529	327	18	,	,	PUNCT
admet-529	327	19	k.s	k.s	PROPN
admet-529	327	20	.	.	PROPN
admet-529	327	21	fors	for	NOUN
admet-529	327	22	,	,	PUNCT
admet-529	327	23	s.	s.	PROPN
admet-529	327	24	jung	jung	PROPN
admet-529	327	25	,	,	PUNCT
admet-529	327	26	j.	j.	PROPN
admet-529	327	27	zhong	zhong	PROPN
admet-529	327	28	,	,	PUNCT
admet-529	327	29	m.w	m.w	PROPN
admet-529	327	30	.	.	PROPN
admet-529	327	31	bundesmann	bundesmann	PROPN
admet-529	327	32	,	,	PUNCT
admet-529	327	33	x.	x.	PROPN
admet-529	327	34	hou	hou	PROPN
admet-529	327	35	,	,	PUNCT
admet-529	327	36	s.	s.	PROPN
admet-529	327	37	lui	lui	PROPN
admet-529	327	38	,	,	PUNCT
admet-529	327	39	r.j	r.j	PROPN
admet-529	327	40	.	.	PROPN
admet-529	327	41	kleiman	kleiman	PROPN
admet-529	327	42	,	,	PUNCT
admet-529	327	43	m.	m.	NOUN
admet-529	327	44	vanase	vanase	NOUN
admet-529	327	45	-	-	PUNCT
admet-529	327	46	frawley	frawley	PROPN
admet-529	327	47	,	,	PUNCT
admet-529	327	48	a.w	a.w	PROPN
admet-529	327	49	.	.	PROPN
admet-529	327	50	schmidt	schmidt	PROPN
admet-529	327	51	,	,	PUNCT
admet-529	327	52	f.	f.	PROPN
admet-529	327	53	menniti	menniti	PROPN
admet-529	327	54	,	,	PUNCT
admet-529	327	55	c.j	c.j	PROPN
admet-529	327	56	.	.	PROPN
admet-529	327	57	schmidt	schmidt	PROPN
admet-529	327	58	,	,	PUNCT
admet-529	327	59	w.e	w.e	PROPN
admet-529	327	60	.	.	PROPN
admet-529	327	61	hoffman	hoffman	PROPN
admet-529	327	62	,	,	PUNCT
admet-529	327	63	m.	m.	NOUN
admet-529	327	64	hajos	hajos	PROPN
admet-529	327	65	,	,	PUNCT
admet-529	327	66	l.	l.	PROPN
admet-529	327	67	mcdowell	mcdowell	PROPN
admet-529	327	68	,	,	PUNCT
admet-529	327	69	r.e	r.e	PROPN
admet-529	327	70	.	.	PROPN
admet-529	327	71	o’connor	o’connor	PROPN
admet-529	327	72	,	,	PUNCT
admet-529	327	73	m.	m.	NOUN
admet-529	327	74	macdougall	macdougall	PROPN
admet-529	327	75	-	-	PUNCT
admet-529	327	76	murphy	murphy	PROPN
admet-529	327	77	,	,	PUNCT
admet-529	327	78	k.r	k.r	PROPN
admet-529	327	79	.	.	PROPN
admet-529	327	80	fonseca	fonseca	PROPN
admet-529	327	81	,	,	PUNCT
admet-529	327	82	s.l	s.l	PROPN
admet-529	327	83	.	.	PROPN
admet-529	327	84	becker	becker	PROPN
admet-529	327	85	,	,	PUNCT
admet-529	327	86	f.r	f.r	PROPN
admet-529	327	87	.	.	PROPN
admet-529	327	88	nelson	nelson	PROPN
admet-529	327	89	,	,	PUNCT
admet-529	327	90	s.	s.	PROPN
admet-529	327	91	liras	liras	PROPN
admet-529	327	92	.	.	PUNCT
admet-529	327	93	application	application	NOUN
admet-529	327	94	of	of	ADP
admet-529	327	95	structure	structure	NOUN
admet-529	327	96	-	-	PUNCT
admet-529	327	97	based	base	VERB
admet-529	327	98	drug	drug	NOUN
admet-529	327	99	design	design	NOUN
admet-529	327	100	and	and	CCONJ
admet-529	327	101	parallel	parallel	ADJ
admet-529	327	102	chemistry	chemistry	NOUN
admet-529	327	103	to	to	PART
admet-529	327	104	identify	identify	VERB
admet-529	327	105	admet	admet	PROPN
admet-529	327	106	&	&	CCONJ
admet-529	327	107	dmpk	dmpk	PROPN
admet-529	327	108	6(2	6(2	NUM
admet-529	327	109	)	)	PUNCT
admet-529	327	110	(	(	PUNCT
admet-529	327	111	2018	2018	NUM
admet-529	327	112	)	)	PUNCT
admet-529	327	113	85	85	NUM
admet-529	327	114	-	-	SYM
admet-529	327	115	104	104	NUM
admet-529	327	116	leveraging	leverage	VERB
admet-529	327	117	chromatography	chromatography	NOUN
admet-529	327	118	physchem	physchem	NOUN
admet-529	327	119	properties	property	NOUN
admet-529	327	120	in	in	ADP
admet-529	327	121	drug	drug	NOUN
admet-529	327	122	design	design	NOUN
admet-529	327	123	doi	doi	NOUN
admet-529	327	124	:	:	PUNCT
admet-529	327	125	10.5599	10.5599	NUM
admet-529	327	126	/	/	SYM
admet-529	327	127	admet.529	admet.529	NOUN
admet-529	327	128	99	99	NUM
admet-529	327	129	selective	selective	ADJ
admet-529	327	130	,	,	PUNCT
admet-529	327	131	brain	brain	NOUN
admet-529	327	132	penetrant	penetrant	NOUN
admet-529	327	133	,	,	PUNCT
admet-529	327	134	in	in	ADP
admet-529	327	135	vivo	vivo	ADJ
admet-529	327	136	active	active	ADJ
admet-529	327	137	phosphodiesterase	phosphodiesterase	NOUN
admet-529	327	138	9a	9a	NOUN
admet-529	327	139	inhibitors	inhibitor	NOUN
admet-529	327	140	.	.	PUNCT
admet-529	328	1	journal	journal	NOUN
admet-529	328	2	of	of	ADP
admet-529	328	3	medicinal	medicinal	ADJ
admet-529	328	4	chemistry	chemistry	NOUN
admet-529	328	5	55	55	NUM
admet-529	328	6	(	(	PUNCT
admet-529	328	7	2012	2012	NUM
admet-529	328	8	)	)	PUNCT
admet-529	328	9	9055	9055	NUM
admet-529	328	10	-	-	SYM
admet-529	328	11	9068	9068	NUM
admet-529	328	12	.	.	PUNCT
admet-529	329	1	[	[	X
admet-529	329	2	14	14	NUM
admet-529	329	3	]	]	X
admet-529	329	4	m.p	m.p	PROPN
admet-529	329	5	.	.	PROPN
admet-529	329	6	gleeson	gleeson	NOUN
admet-529	329	7	.	.	PUNCT
admet-529	330	1	generation	generation	NOUN
admet-529	330	2	of	of	ADP
admet-529	330	3	a	a	DET
admet-529	330	4	set	set	NOUN
admet-529	330	5	of	of	ADP
admet-529	330	6	simple	simple	ADJ
admet-529	330	7	,	,	PUNCT
admet-529	330	8	interpretable	interpretable	ADJ
admet-529	330	9	admet	admet	NOUN
admet-529	330	10	rules	rule	NOUN
admet-529	330	11	of	of	ADP
admet-529	330	12	thumb	thumb	NOUN
admet-529	330	13	.	.	PUNCT
admet-529	331	1	journal	journal	NOUN
admet-529	331	2	of	of	ADP
admet-529	331	3	medicinal	medicinal	ADJ
admet-529	331	4	chemistry	chemistry	NOUN
admet-529	331	5	51	51	NUM
admet-529	331	6	(	(	PUNCT
admet-529	331	7	2008	2008	NUM
admet-529	331	8	)	)	PUNCT
admet-529	331	9	817	817	NUM
admet-529	331	10	-	-	SYM
admet-529	331	11	834	834	NUM
admet-529	331	12	.	.	PUNCT
admet-529	332	1	[	[	X
admet-529	332	2	15	15	NUM
admet-529	332	3	]	]	X
admet-529	332	4	m.v	m.v	PROPN
admet-529	332	5	.	.	PROPN
admet-529	332	6	varma	varma	PROPN
admet-529	332	7	,	,	PUNCT
admet-529	332	8	r.s	r.s	PROPN
admet-529	332	9	.	.	PROPN
admet-529	332	10	obach	obach	PROPN
admet-529	332	11	,	,	PUNCT
admet-529	332	12	c.	c.	PROPN
admet-529	332	13	rotter	rotter	PROPN
admet-529	332	14	,	,	PUNCT
admet-529	332	15	h.r	h.r	PROPN
admet-529	332	16	.	.	PROPN
admet-529	332	17	miller	miller	PROPN
admet-529	332	18	,	,	PUNCT
admet-529	332	19	g.	g.	PROPN
admet-529	332	20	chang	chang	PROPN
admet-529	332	21	,	,	PUNCT
admet-529	332	22	s.j	s.j	PROPN
admet-529	332	23	.	.	PROPN
admet-529	332	24	steyn	steyn	PROPN
admet-529	332	25	,	,	PUNCT
admet-529	332	26	a.	a.	PROPN
admet-529	332	27	el	el	PROPN
admet-529	332	28	-	-	PROPN
admet-529	332	29	kattan	kattan	PROPN
admet-529	332	30	,	,	PUNCT
admet-529	332	31	m.d	m.d	PROPN
admet-529	332	32	.	.	PROPN
admet-529	332	33	troutman	troutman	PROPN
admet-529	332	34	.	.	PUNCT
admet-529	333	1	physicochemical	physicochemical	ADJ
admet-529	333	2	space	space	NOUN
admet-529	333	3	for	for	ADP
admet-529	333	4	optimum	optimum	ADJ
admet-529	333	5	oral	oral	ADJ
admet-529	333	6	bioavailability	bioavailability	NOUN
admet-529	333	7	:	:	PUNCT
admet-529	333	8	contribution	contribution	NOUN
admet-529	333	9	of	of	ADP
admet-529	333	10	human	human	ADJ
admet-529	333	11	intestinal	intestinal	ADJ
admet-529	333	12	absorption	absorption	NOUN
admet-529	333	13	and	and	CCONJ
admet-529	333	14	first	first	ADJ
admet-529	333	15	-	-	PUNCT
admet-529	333	16	pass	pass	NOUN
admet-529	333	17	elimination	elimination	NOUN
admet-529	333	18	.	.	PUNCT
admet-529	334	1	j	j	PROPN
admet-529	334	2	med	med	PROPN
admet-529	334	3	chem	chem	NOUN
admet-529	334	4	53	53	NUM
admet-529	334	5	(	(	PUNCT
admet-529	334	6	2010	2010	NUM
admet-529	334	7	)	)	PUNCT
admet-529	334	8	1098	1098	NUM
admet-529	334	9	-	-	SYM
admet-529	334	10	1108	1108	NUM
admet-529	334	11	.	.	PUNCT
admet-529	335	1	[	[	X
admet-529	335	2	16	16	NUM
admet-529	335	3	]	]	X
admet-529	335	4	t.w	t.w	PROPN
admet-529	335	5	.	.	PROPN
admet-529	335	6	johnson	johnson	PROPN
admet-529	335	7	,	,	PUNCT
admet-529	335	8	k.r	k.r	PROPN
admet-529	335	9	.	.	PROPN
admet-529	335	10	dress	dress	PROPN
admet-529	335	11	,	,	PUNCT
admet-529	335	12	m.	m.	NOUN
admet-529	335	13	edwards	edwards	PROPN
admet-529	335	14	.	.	PUNCT
admet-529	336	1	using	use	VERB
admet-529	336	2	the	the	DET
admet-529	336	3	golden	golden	ADJ
admet-529	336	4	triangle	triangle	NOUN
admet-529	336	5	to	to	PART
admet-529	336	6	optimize	optimize	VERB
admet-529	336	7	clearance	clearance	NOUN
admet-529	336	8	and	and	CCONJ
admet-529	336	9	oral	oral	ADJ
admet-529	336	10	absorption	absorption	NOUN
admet-529	336	11	.	.	PUNCT
admet-529	337	1	bioorganic	bioorganic	PROPN
admet-529	337	2	&	&	CCONJ
admet-529	337	3	medicinal	medicinal	ADJ
admet-529	337	4	chemistry	chemistry	NOUN
admet-529	337	5	letters	letter	NOUN
admet-529	337	6	19	19	NUM
admet-529	337	7	(	(	PUNCT
admet-529	337	8	2009	2009	NUM
admet-529	337	9	)	)	PUNCT
admet-529	337	10	5560	5560	NUM
admet-529	337	11	-	-	SYM
admet-529	337	12	5564	5564	NUM
admet-529	337	13	.	.	PUNCT
admet-529	338	1	[	[	X
admet-529	338	2	17	17	NUM
admet-529	338	3	]	]	X
admet-529	338	4	a.l	a.l	PROPN
admet-529	338	5	.	.	PROPN
admet-529	338	6	hopkins	hopkins	PROPN
admet-529	338	7	,	,	PUNCT
admet-529	338	8	g.m	g.m	PROPN
admet-529	338	9	.	.	PROPN
admet-529	338	10	keserü	keserü	PROPN
admet-529	338	11	,	,	PUNCT
admet-529	338	12	p.d	p.d	PROPN
admet-529	338	13	.	.	PROPN
admet-529	338	14	leeson	leeson	PROPN
admet-529	338	15	,	,	PUNCT
admet-529	338	16	d.c	d.c	PROPN
admet-529	338	17	.	.	PROPN
admet-529	338	18	rees	rees	PROPN
admet-529	338	19	,	,	PUNCT
admet-529	338	20	c.h	c.h	PROPN
admet-529	338	21	.	.	PROPN
admet-529	338	22	reynolds	reynolds	PROPN
admet-529	338	23	.	.	PUNCT
admet-529	339	1	the	the	DET
admet-529	339	2	role	role	NOUN
admet-529	339	3	of	of	ADP
admet-529	339	4	ligand	ligand	ADJ
admet-529	339	5	efficiency	efficiency	NOUN
admet-529	339	6	metrics	metric	NOUN
admet-529	339	7	in	in	ADP
admet-529	339	8	drug	drug	NOUN
admet-529	339	9	discovery	discovery	NOUN
admet-529	339	10	.	.	PUNCT
admet-529	340	1	nature	nature	NOUN
admet-529	340	2	reviews	review	VERB
admet-529	340	3	drug	drug	NOUN
admet-529	340	4	discovery	discovery	NOUN
admet-529	340	5	13	13	NUM
admet-529	340	6	(	(	PUNCT
admet-529	340	7	2014	2014	NUM
admet-529	340	8	)	)	PUNCT
admet-529	340	9	105	105	NUM
admet-529	340	10	.	.	PUNCT
admet-529	341	1	[	[	X
admet-529	341	2	18	18	NUM
admet-529	341	3	]	]	X
admet-529	341	4	j.s	j.s	PROPN
admet-529	341	5	.	.	PROPN
admet-529	341	6	scott	scott	PROPN
admet-529	341	7	,	,	PUNCT
admet-529	341	8	m.j	m.j	PROPN
admet-529	341	9	.	.	PROPN
admet-529	341	10	waring	waring	NOUN
admet-529	341	11	.	.	PUNCT
admet-529	342	1	practical	practical	ADJ
admet-529	342	2	application	application	NOUN
admet-529	342	3	of	of	ADP
admet-529	342	4	ligand	ligand	NOUN
admet-529	342	5	efficiency	efficiency	NOUN
admet-529	342	6	metrics	metric	NOUN
admet-529	342	7	in	in	ADP
admet-529	342	8	lead	lead	ADJ
admet-529	342	9	optimisation	optimisation	NOUN
admet-529	342	10	.	.	PUNCT
admet-529	343	1	bioorganic	bioorganic	PROPN
admet-529	343	2	&	&	CCONJ
admet-529	343	3	medicinal	medicinal	ADJ
admet-529	343	4	chemistry	chemistry	NOUN
admet-529	343	5	(	(	PUNCT
admet-529	343	6	2018	2018	NUM
admet-529	343	7	)	)	PUNCT
admet-529	343	8	.	.	PUNCT
admet-529	344	1	[	[	X
admet-529	344	2	19	19	NUM
admet-529	344	3	]	]	X
admet-529	344	4	r.j	r.j	PROPN
admet-529	344	5	.	.	PROPN
admet-529	344	6	young	young	PROPN
admet-529	344	7	,	,	PUNCT
admet-529	344	8	p.d	p.d	PROPN
admet-529	344	9	.	.	PROPN
admet-529	344	10	leeson	leeson	PROPN
admet-529	344	11	.	.	PUNCT
admet-529	345	1	mapping	map	VERB
admet-529	345	2	the	the	DET
admet-529	345	3	efficiency	efficiency	NOUN
admet-529	345	4	and	and	CCONJ
admet-529	345	5	physicochemical	physicochemical	ADJ
admet-529	345	6	trajectories	trajectory	NOUN
admet-529	345	7	of	of	ADP
admet-529	345	8	successful	successful	ADJ
admet-529	345	9	optimizations	optimization	NOUN
admet-529	345	10	.	.	PUNCT
admet-529	346	1	journal	journal	NOUN
admet-529	346	2	of	of	ADP
admet-529	346	3	medicinal	medicinal	ADJ
admet-529	346	4	chemistry	chemistry	NOUN
admet-529	346	5	(	(	PUNCT
admet-529	346	6	2018	2018	NUM
admet-529	346	7	)	)	PUNCT
admet-529	346	8	.	.	PUNCT
admet-529	347	1	[	[	X
admet-529	347	2	20	20	NUM
admet-529	347	3	]	]	X
admet-529	347	4	t.w	t.w	PROPN
admet-529	347	5	.	.	PROPN
admet-529	347	6	johnson	johnson	PROPN
admet-529	347	7	,	,	PUNCT
admet-529	347	8	r.a	r.a	PROPN
admet-529	347	9	.	.	PROPN
admet-529	347	10	gallego	gallego	PROPN
admet-529	347	11	,	,	PUNCT
admet-529	347	12	m.p	m.p	PROPN
admet-529	347	13	.	.	PROPN
admet-529	347	14	edwards	edwards	PROPN
admet-529	347	15	.	.	PUNCT
admet-529	347	16	lipophilic	lipophilic	ADJ
admet-529	347	17	efficiency	efficiency	NOUN
admet-529	347	18	as	as	ADP
admet-529	347	19	an	an	DET
admet-529	347	20	important	important	ADJ
admet-529	347	21	metric	metric	NOUN
admet-529	347	22	in	in	ADP
admet-529	347	23	drug	drug	NOUN
admet-529	347	24	design	design	NOUN
admet-529	347	25	.	.	PUNCT
admet-529	348	1	journal	journal	NOUN
admet-529	348	2	of	of	ADP
admet-529	348	3	medicinal	medicinal	ADJ
admet-529	348	4	chemistry	chemistry	NOUN
admet-529	348	5	(	(	PUNCT
admet-529	348	6	2018	2018	NUM
admet-529	348	7	)	)	PUNCT
admet-529	348	8	.	.	PUNCT
admet-529	349	1	[	[	X
admet-529	349	2	21	21	NUM
admet-529	349	3	]	]	X
admet-529	349	4	c.r	c.r	PROPN
admet-529	349	5	.	.	PROPN
admet-529	349	6	butler	butler	PROPN
admet-529	349	7	,	,	PUNCT
admet-529	349	8	e.m	e.m	PROPN
admet-529	349	9	.	.	PROPN
admet-529	349	10	beck	beck	PROPN
admet-529	349	11	,	,	PUNCT
admet-529	349	12	a.	a.	PROPN
admet-529	349	13	harris	harris	PROPN
admet-529	349	14	,	,	PUNCT
admet-529	349	15	z.	z.	PROPN
admet-529	349	16	huang	huang	PROPN
admet-529	349	17	,	,	PUNCT
admet-529	349	18	l.a	l.a	PROPN
admet-529	349	19	.	.	PROPN
admet-529	349	20	mcallister	mcallister	PROPN
admet-529	349	21	,	,	PUNCT
admet-529	349	22	c.w	c.w	PROPN
admet-529	349	23	.	.	PROPN
admet-529	349	24	am	be	AUX
admet-529	349	25	ende	ende	NOUN
admet-529	349	26	,	,	PUNCT
admet-529	349	27	k.	k.	PROPN
admet-529	349	28	fennell	fennell	PROPN
admet-529	349	29	,	,	PUNCT
admet-529	349	30	t.l	t.l	PROPN
admet-529	349	31	.	.	PUNCT
admet-529	349	32	foley	foley	PROPN
admet-529	349	33	,	,	PUNCT
admet-529	349	34	k.	k.	PROPN
admet-529	349	35	fonseca	fonseca	PROPN
admet-529	349	36	,	,	PUNCT
admet-529	349	37	s.j	s.j	PROPN
admet-529	349	38	.	.	PROPN
admet-529	349	39	hawrylik	hawrylik	PROPN
admet-529	349	40	,	,	PUNCT
admet-529	349	41	d.s	d.s	PROPN
admet-529	349	42	.	.	PROPN
admet-529	349	43	johnson	johnson	PROPN
admet-529	349	44	,	,	PUNCT
admet-529	349	45	j.d	j.d	PROPN
admet-529	349	46	.	.	PROPN
admet-529	349	47	knafels	knafels	PROPN
admet-529	349	48	,	,	PUNCT
admet-529	349	49	s.	s.	PROPN
admet-529	349	50	mente	mente	PROPN
admet-529	349	51	,	,	PUNCT
admet-529	349	52	g.s	g.s	PROPN
admet-529	349	53	.	.	PROPN
admet-529	349	54	noell	noell	PROPN
admet-529	349	55	,	,	PUNCT
admet-529	349	56	j.	j.	PROPN
admet-529	349	57	pandit	pandit	PROPN
admet-529	349	58	,	,	PUNCT
admet-529	349	59	t.b	t.b	PROPN
admet-529	349	60	.	.	PROPN
admet-529	349	61	phillips	phillips	PROPN
admet-529	349	62	,	,	PUNCT
admet-529	349	63	j.r	j.r	PROPN
admet-529	349	64	.	.	PROPN
admet-529	349	65	piro	piro	PROPN
admet-529	349	66	,	,	PUNCT
admet-529	349	67	b.n	b.n	PROPN
admet-529	349	68	.	.	PROPN
admet-529	349	69	rogers	rogers	PROPN
admet-529	349	70	,	,	PUNCT
admet-529	349	71	t.a	t.a	PROPN
admet-529	349	72	.	.	PROPN
admet-529	349	73	samad	samad	PROPN
admet-529	349	74	,	,	PUNCT
admet-529	349	75	j.	j.	PROPN
admet-529	349	76	wang	wang	PROPN
admet-529	349	77	,	,	PUNCT
admet-529	349	78	s.	s.	PROPN
admet-529	349	79	wan	wan	PROPN
admet-529	349	80	,	,	PUNCT
admet-529	349	81	m.a	m.a	PROPN
admet-529	349	82	.	.	PROPN
admet-529	349	83	brodney	brodney	PROPN
admet-529	349	84	.	.	PUNCT
admet-529	350	1	azetidine	azetidine	PROPN
admet-529	350	2	and	and	CCONJ
admet-529	350	3	piperidine	piperidine	NOUN
admet-529	350	4	carbamates	carbamate	NOUN
admet-529	350	5	as	as	ADP
admet-529	350	6	efficient	efficient	ADJ
admet-529	350	7	,	,	PUNCT
admet-529	350	8	covalent	covalent	ADJ
admet-529	350	9	inhibitors	inhibitor	NOUN
admet-529	350	10	of	of	ADP
admet-529	350	11	monoacylglycerol	monoacylglycerol	PROPN
admet-529	350	12	lipase	lipase	PROPN
admet-529	350	13	.	.	PUNCT
admet-529	351	1	journal	journal	NOUN
admet-529	351	2	of	of	ADP
admet-529	351	3	medicinal	medicinal	ADJ
admet-529	351	4	chemistry	chemistry	NOUN
admet-529	351	5	60	60	NUM
admet-529	351	6	(	(	PUNCT
admet-529	351	7	2017	2017	NUM
admet-529	351	8	)	)	PUNCT
admet-529	351	9	9860	9860	NUM
admet-529	351	10	-	-	SYM
admet-529	351	11	9873	9873	NUM
admet-529	351	12	.	.	PUNCT
admet-529	352	1	[	[	X
admet-529	352	2	22	22	NUM
admet-529	352	3	]	]	PUNCT
admet-529	352	4	m.	m.	NOUN
admet-529	352	5	ammirati	ammirati	PROPN
admet-529	352	6	,	,	PUNCT
admet-529	352	7	s.w	s.w	PROPN
admet-529	352	8	.	.	PROPN
admet-529	352	9	bagley	bagley	PROPN
admet-529	352	10	,	,	PUNCT
admet-529	352	11	s.k	s.k	PROPN
admet-529	352	12	.	.	PROPN
admet-529	352	13	bhattacharya	bhattacharya	PROPN
admet-529	352	14	,	,	PUNCT
admet-529	352	15	l.	l.	PROPN
admet-529	352	16	buckbinder	buckbinder	PROPN
admet-529	352	17	,	,	PUNCT
admet-529	352	18	a.a	a.a	PROPN
admet-529	352	19	.	.	PROPN
admet-529	352	20	carlo	carlo	PROPN
admet-529	352	21	,	,	PUNCT
admet-529	352	22	r.	r.	PROPN
admet-529	352	23	conrad	conrad	PROPN
admet-529	352	24	,	,	PUNCT
admet-529	352	25	c.	c.	PROPN
admet-529	352	26	cortes	cortes	PROPN
admet-529	352	27	,	,	PUNCT
admet-529	352	28	r.l	r.l	PROPN
admet-529	352	29	.	.	PROPN
admet-529	352	30	dow	dow	PROPN
admet-529	352	31	,	,	PUNCT
admet-529	352	32	m.s	m.s	PROPN
admet-529	352	33	.	.	PROPN
admet-529	352	34	dowling	dowling	PROPN
admet-529	352	35	,	,	PUNCT
admet-529	352	36	a.	a.	PROPN
admet-529	352	37	el	el	PROPN
admet-529	352	38	-	-	PUNCT
admet-529	352	39	kattan	kattan	PROPN
admet-529	352	40	,	,	PUNCT
admet-529	352	41	k.	k.	PROPN
admet-529	352	42	ford	ford	PROPN
admet-529	352	43	,	,	PUNCT
admet-529	352	44	c.r.w	c.r.w	PROPN
admet-529	352	45	.	.	PUNCT
admet-529	352	46	guimarães	guimarães	PROPN
admet-529	352	47	,	,	PUNCT
admet-529	352	48	d.	d.	PROPN
admet-529	352	49	hepworth	hepworth	PROPN
admet-529	352	50	,	,	PUNCT
admet-529	352	51	w.	w.	PROPN
admet-529	352	52	jiao	jiao	PROPN
admet-529	352	53	,	,	PUNCT
admet-529	352	54	j.	j.	PROPN
admet-529	352	55	laperle	laperle	PROPN
admet-529	352	56	,	,	PUNCT
admet-529	352	57	s.	s.	PROPN
admet-529	352	58	liu	liu	PROPN
admet-529	352	59	,	,	PUNCT
admet-529	352	60	a.	a.	NOUN
admet-529	352	61	londregan	londregan	NOUN
admet-529	352	62	,	,	PUNCT
admet-529	352	63	p.m.	p.m.	PROPN
admet-529	352	64	loria	loria	PROPN
admet-529	352	65	,	,	PUNCT
admet-529	352	66	a.m.	a.m.	PROPN
admet-529	352	67	mathiowetz	mathiowetz	PROPN
admet-529	352	68	,	,	PUNCT
admet-529	352	69	m.	m.	NOUN
admet-529	352	70	munchhof	munchhof	NOUN
admet-529	352	71	,	,	PUNCT
admet-529	352	72	s.t.m	s.t.m	PROPN
admet-529	352	73	.	.	PUNCT
admet-529	352	74	orr	orr	PROPN
admet-529	352	75	,	,	PUNCT
admet-529	352	76	d.n	d.n	PROPN
admet-529	352	77	.	.	PROPN
admet-529	352	78	petersen	petersen	PROPN
admet-529	352	79	,	,	PUNCT
admet-529	352	80	d.a	d.a	PROPN
admet-529	352	81	.	.	PROPN
admet-529	352	82	price	price	NOUN
admet-529	352	83	,	,	PUNCT
admet-529	352	84	a.	a.	NOUN
admet-529	352	85	skoura	skoura	PROPN
admet-529	352	86	,	,	PUNCT
admet-529	352	87	a.c	a.c	PROPN
admet-529	352	88	.	.	PROPN
admet-529	352	89	smith	smith	PROPN
admet-529	352	90	,	,	PUNCT
admet-529	352	91	j.	j.	PROPN
admet-529	352	92	wang	wang	PROPN
admet-529	352	93	.	.	PUNCT
admet-529	353	1	discovery	discovery	PROPN
admet-529	353	2	of	of	ADP
admet-529	353	3	an	an	DET
admet-529	353	4	in	in	ADP
admet-529	353	5	vivo	vivo	ADJ
admet-529	353	6	tool	tool	NOUN
admet-529	353	7	to	to	PART
admet-529	353	8	establish	establish	VERB
admet-529	353	9	proof	proof	NOUN
admet-529	353	10	-	-	PUNCT
admet-529	353	11	of	of	ADP
admet-529	353	12	-	-	PUNCT
admet-529	353	13	concept	concept	NOUN
admet-529	353	14	for	for	ADP
admet-529	353	15	map4k4based	map4k4base	VERB
admet-529	353	16	antidiabetic	antidiabetic	ADJ
admet-529	353	17	treatment	treatment	NOUN
admet-529	353	18	.	.	PUNCT
admet-529	354	1	acs	acs	PROPN
admet-529	354	2	medicinal	medicinal	ADJ
admet-529	354	3	chemistry	chemistry	NOUN
admet-529	354	4	letters	letter	NOUN
admet-529	354	5	6	6	NUM
admet-529	354	6	(	(	PUNCT
admet-529	354	7	2015	2015	NUM
admet-529	354	8	)	)	PUNCT
admet-529	354	9	1128	1128	NUM
admet-529	354	10	-	-	SYM
admet-529	354	11	1133	1133	NUM
admet-529	354	12	.	.	PUNCT
admet-529	355	1	[	[	X
admet-529	355	2	23	23	NUM
admet-529	355	3	]	]	X
admet-529	355	4	m.	m.	NOUN
admet-529	355	5	pettersson	pettersson	PROPN
admet-529	355	6	,	,	PUNCT
admet-529	355	7	d.s	d.s	PROPN
admet-529	355	8	.	.	PROPN
admet-529	355	9	johnson	johnson	PROPN
admet-529	355	10	,	,	PUNCT
admet-529	355	11	c.	c.	PROPN
admet-529	355	12	subramanyam	subramanyam	PROPN
admet-529	355	13	,	,	PUNCT
admet-529	355	14	k.r	k.r	PROPN
admet-529	355	15	.	.	PROPN
admet-529	355	16	bales	bale	NOUN
admet-529	355	17	,	,	PUNCT
admet-529	355	18	c.w	c.w	PROPN
admet-529	355	19	.	.	PROPN
admet-529	355	20	am	be	AUX
admet-529	355	21	ende	ende	NOUN
admet-529	355	22	,	,	PUNCT
admet-529	355	23	b.a	b.a	PROPN
admet-529	355	24	.	.	PROPN
admet-529	355	25	fish	fish	PROPN
admet-529	355	26	,	,	PUNCT
admet-529	355	27	m.e	m.e	PROPN
admet-529	355	28	.	.	PROPN
admet-529	355	29	green	green	PROPN
admet-529	355	30	,	,	PUNCT
admet-529	355	31	g.w	g.w	PROPN
admet-529	355	32	.	.	PROPN
admet-529	355	33	kauffman	kauffman	PROPN
admet-529	355	34	,	,	PUNCT
admet-529	355	35	p.b	p.b	PROPN
admet-529	355	36	.	.	PROPN
admet-529	355	37	mullins	mullins	PROPN
admet-529	355	38	,	,	PUNCT
admet-529	355	39	t.	t.	PROPN
admet-529	355	40	navaratnam	navaratnam	PROPN
admet-529	355	41	,	,	PUNCT
admet-529	355	42	s.m	s.m	PROPN
admet-529	355	43	.	.	PROPN
admet-529	355	44	sakya	sakya	PROPN
admet-529	355	45	,	,	PUNCT
admet-529	355	46	c.m	c.m	PROPN
admet-529	355	47	.	.	PROPN
admet-529	355	48	stiff	stiff	PROPN
admet-529	355	49	,	,	PUNCT
admet-529	355	50	t.p	t.p	PROPN
admet-529	355	51	.	.	PROPN
admet-529	355	52	tran	tran	PROPN
admet-529	355	53	,	,	PUNCT
admet-529	355	54	l.	l.	PROPN
admet-529	355	55	xie	xie	PROPN
admet-529	355	56	,	,	PUNCT
admet-529	355	57	l.	l.	PROPN
admet-529	355	58	zhang	zhang	PROPN
admet-529	355	59	,	,	PUNCT
admet-529	355	60	l.r	l.r	PROPN
admet-529	355	61	.	.	PROPN
admet-529	355	62	pustilnik	pustilnik	PROPN
admet-529	355	63	,	,	PUNCT
admet-529	355	64	b.c	b.c	PROPN
admet-529	355	65	.	.	PROPN
admet-529	355	66	vetelino	vetelino	PROPN
admet-529	355	67	,	,	PUNCT
admet-529	355	68	k.m	k.m	PROPN
admet-529	355	69	.	.	PROPN
admet-529	355	70	wood	wood	PROPN
admet-529	355	71	,	,	PUNCT
admet-529	355	72	n.	n.	NOUN
admet-529	355	73	pozdnyakov	pozdnyakov	PROPN
admet-529	355	74	,	,	PUNCT
admet-529	355	75	p.r	p.r	PROPN
admet-529	355	76	.	.	PROPN
admet-529	355	77	verhoest	verhoest	PROPN
admet-529	355	78	,	,	PUNCT
admet-529	355	79	c.j	c.j	PROPN
admet-529	355	80	.	.	NOUN
admet-529	355	81	o’donnell	o’donnell	PROPN
admet-529	355	82	.	.	PUNCT
admet-529	356	1	design	design	NOUN
admet-529	356	2	,	,	PUNCT
admet-529	356	3	synthesis	synthesis	NOUN
admet-529	356	4	,	,	PUNCT
admet-529	356	5	and	and	CCONJ
admet-529	356	6	pharmacological	pharmacological	ADJ
admet-529	356	7	evaluation	evaluation	NOUN
admet-529	356	8	of	of	ADP
admet-529	356	9	a	a	DET
admet-529	356	10	novel	novel	ADJ
admet-529	356	11	series	series	NOUN
admet-529	356	12	of	of	ADP
admet-529	356	13	pyridopyrazine-1,6	pyridopyrazine-1,6	PROPN
admet-529	356	14	-	-	PUNCT
admet-529	356	15	dione	dione	NOUN
admet-529	356	16	γ	γ	NOUN
admet-529	356	17	-	-	PUNCT
admet-529	356	18	secretase	secretase	ADJ
admet-529	356	19	modulators	modulator	NOUN
admet-529	356	20	.	.	PUNCT
admet-529	357	1	journal	journal	NOUN
admet-529	357	2	of	of	ADP
admet-529	357	3	medicinal	medicinal	ADJ
admet-529	357	4	chemistry	chemistry	NOUN
admet-529	357	5	57	57	NUM
admet-529	357	6	(	(	PUNCT
admet-529	357	7	2014	2014	NUM
admet-529	357	8	)	)	PUNCT
admet-529	357	9	1046	1046	NUM
admet-529	357	10	-	-	SYM
admet-529	357	11	1062	1062	NUM
admet-529	357	12	.	.	PUNCT
admet-529	358	1	[	[	X
admet-529	358	2	24	24	NUM
admet-529	358	3	]	]	PUNCT
admet-529	358	4	c.	c.	PROPN
admet-529	358	5	hansch	hansch	PROPN
admet-529	358	6	,	,	PUNCT
admet-529	358	7	j.p	j.p	PROPN
admet-529	358	8	.	.	PROPN
admet-529	358	9	bjorkroth	bjorkroth	PROPN
admet-529	358	10	,	,	PUNCT
admet-529	358	11	a.	a.	PROPN
admet-529	358	12	leo	leo	PROPN
admet-529	358	13	.	.	PROPN
admet-529	358	14	hydrophobicity	hydrophobicity	PROPN
admet-529	358	15	and	and	CCONJ
admet-529	358	16	central	central	ADJ
admet-529	358	17	nervous	nervous	ADJ
admet-529	358	18	system	system	NOUN
admet-529	358	19	agents	agent	NOUN
admet-529	358	20	:	:	PUNCT
admet-529	358	21	on	on	ADP
admet-529	358	22	the	the	DET
admet-529	358	23	principle	principle	NOUN
admet-529	358	24	of	of	ADP
admet-529	358	25	minimal	minimal	ADJ
admet-529	358	26	hydrophobicity	hydrophobicity	NOUN
admet-529	358	27	in	in	ADP
admet-529	358	28	drug	drug	NOUN
admet-529	358	29	design	design	NOUN
admet-529	358	30	.	.	PUNCT
admet-529	359	1	j	j	PROPN
admet-529	359	2	pharm	pharm	PROPN
admet-529	359	3	sci	sci	PROPN
admet-529	359	4	76	76	NUM
admet-529	359	5	(	(	PUNCT
admet-529	359	6	1987	1987	NUM
admet-529	359	7	)	)	PUNCT
admet-529	359	8	663	663	NUM
admet-529	359	9	-	-	SYM
admet-529	359	10	687	687	NUM
admet-529	359	11	.	.	PUNCT
admet-529	360	1	[	[	X
admet-529	360	2	25	25	NUM
admet-529	360	3	]	]	X
admet-529	360	4	l.	l.	PROPN
admet-529	360	5	di	di	PROPN
admet-529	360	6	,	,	PUNCT
admet-529	360	7	p.	p.	PROPN
admet-529	360	8	artursson	artursson	PROPN
admet-529	360	9	,	,	PUNCT
admet-529	360	10	a.	a.	PROPN
admet-529	360	11	avdeef	avdeef	PROPN
admet-529	360	12	,	,	PUNCT
admet-529	360	13	g.f	g.f	PROPN
admet-529	360	14	.	.	PROPN
admet-529	360	15	ecker	ecker	PROPN
admet-529	360	16	,	,	PUNCT
admet-529	360	17	b.	b.	PROPN
admet-529	360	18	faller	faller	PROPN
admet-529	360	19	,	,	PUNCT
admet-529	360	20	h.	h.	PROPN
admet-529	360	21	fischer	fischer	PROPN
admet-529	360	22	,	,	PUNCT
admet-529	360	23	j.b	j.b	PROPN
admet-529	360	24	.	.	PROPN
admet-529	360	25	houston	houston	PROPN
admet-529	360	26	,	,	PUNCT
admet-529	360	27	m.	m.	PROPN
admet-529	360	28	kansy	kansy	PROPN
admet-529	360	29	,	,	PUNCT
admet-529	360	30	e.h	e.h	PROPN
admet-529	360	31	.	.	PROPN
admet-529	360	32	kerns	kerns	PROPN
admet-529	360	33	,	,	PUNCT
admet-529	360	34	s.d	s.d	PROPN
admet-529	360	35	.	.	PROPN
admet-529	360	36	krämer	krämer	PROPN
admet-529	360	37	.	.	PUNCT
admet-529	361	1	evidence	evidence	NOUN
admet-529	361	2	-	-	PUNCT
admet-529	361	3	based	base	VERB
admet-529	361	4	approach	approach	NOUN
admet-529	361	5	to	to	PART
admet-529	361	6	assess	assess	VERB
admet-529	361	7	passive	passive	ADJ
admet-529	361	8	diffusion	diffusion	NOUN
admet-529	361	9	and	and	CCONJ
admet-529	361	10	carrier	carrier	NOUN
admet-529	361	11	-	-	PUNCT
admet-529	361	12	mediated	mediate	VERB
admet-529	361	13	drug	drug	NOUN
admet-529	361	14	transport	transport	NOUN
admet-529	361	15	.	.	PUNCT
admet-529	362	1	drug	drug	NOUN
admet-529	362	2	discov	discov	PROPN
admet-529	362	3	today	today	NOUN
admet-529	362	4	17	17	NUM
admet-529	362	5	(	(	PUNCT
admet-529	362	6	2012	2012	NUM
admet-529	362	7	)	)	PUNCT
admet-529	362	8	905	905	NUM
admet-529	362	9	-	-	SYM
admet-529	362	10	912	912	NUM
admet-529	362	11	.	.	PUNCT
admet-529	363	1	[	[	X
admet-529	363	2	26	26	NUM
admet-529	363	3	]	]	X
admet-529	363	4	c.a	c.a	PROPN
admet-529	363	5	.	.	PROPN
admet-529	363	6	lipinski	lipinski	PROPN
admet-529	363	7	,	,	PUNCT
admet-529	363	8	f.	f.	PROPN
admet-529	363	9	lombardo	lombardo	PROPN
admet-529	363	10	,	,	PUNCT
admet-529	363	11	b.w	b.w	PROPN
admet-529	363	12	.	.	PROPN
admet-529	363	13	dominy	dominy	PROPN
admet-529	363	14	,	,	PUNCT
admet-529	363	15	p.j	p.j	PROPN
admet-529	363	16	.	.	PROPN
admet-529	363	17	feeney	feeney	PROPN
admet-529	363	18	.	.	PUNCT
admet-529	364	1	experimental	experimental	ADJ
admet-529	364	2	and	and	CCONJ
admet-529	364	3	computational	computational	ADJ
admet-529	364	4	approaches	approach	NOUN
admet-529	364	5	to	to	PART
admet-529	364	6	estimate	estimate	VERB
admet-529	364	7	solubility	solubility	NOUN
admet-529	364	8	and	and	CCONJ
admet-529	364	9	permeability	permeability	NOUN
admet-529	364	10	in	in	ADP
admet-529	364	11	drug	drug	NOUN
admet-529	364	12	discovery	discovery	NOUN
admet-529	364	13	and	and	CCONJ
admet-529	364	14	development	development	NOUN
admet-529	364	15	settings1	settings1	PROPN
admet-529	364	16	.	.	PUNCT
admet-529	365	1	advanced	advanced	ADJ
admet-529	365	2	drug	drug	NOUN
admet-529	365	3	delivery	delivery	NOUN
admet-529	365	4	reviews	review	VERB
admet-529	365	5	23	23	NUM
admet-529	365	6	(	(	PUNCT
admet-529	365	7	1997	1997	NUM
admet-529	365	8	)	)	PUNCT
admet-529	365	9	3	3	NUM
admet-529	365	10	-	-	SYM
admet-529	365	11	25	25	NUM
admet-529	365	12	.	.	PUNCT
admet-529	366	1	[	[	X
admet-529	366	2	27	27	NUM
admet-529	366	3	]	]	X
admet-529	366	4	c.a	c.a	PROPN
admet-529	366	5	.	.	PROPN
admet-529	366	6	lipinski	lipinski	PROPN
admet-529	366	7	,	,	PUNCT
admet-529	366	8	f.	f.	PROPN
admet-529	366	9	lombardo	lombardo	PROPN
admet-529	366	10	,	,	PUNCT
admet-529	366	11	b.w	b.w	PROPN
admet-529	366	12	.	.	PROPN
admet-529	366	13	dominy	dominy	PROPN
admet-529	366	14	,	,	PUNCT
admet-529	366	15	p.j	p.j	PROPN
admet-529	366	16	.	.	PROPN
admet-529	366	17	feeney	feeney	PROPN
admet-529	366	18	.	.	PUNCT
admet-529	367	1	experimental	experimental	ADJ
admet-529	367	2	and	and	CCONJ
admet-529	367	3	computational	computational	ADJ
admet-529	367	4	approaches	approach	NOUN
admet-529	367	5	to	to	PART
admet-529	367	6	estimate	estimate	VERB
admet-529	367	7	solubility	solubility	NOUN
admet-529	367	8	and	and	CCONJ
admet-529	367	9	permeability	permeability	NOUN
admet-529	367	10	in	in	ADP
admet-529	367	11	drug	drug	NOUN
admet-529	367	12	discovery	discovery	NOUN
admet-529	367	13	and	and	CCONJ
admet-529	367	14	development	development	NOUN
admet-529	367	15	settings	setting	NOUN
admet-529	367	16	.	.	PUNCT
admet-529	368	1	advanced	advanced	ADJ
admet-529	368	2	drug	drug	NOUN
admet-529	368	3	delivery	delivery	NOUN
admet-529	368	4	reviews	review	VERB
admet-529	368	5	46	46	NUM
admet-529	368	6	(	(	PUNCT
admet-529	368	7	2001	2001	NUM
admet-529	368	8	)	)	PUNCT
admet-529	368	9	3	3	NUM
admet-529	368	10	-	-	SYM
admet-529	368	11	26	26	NUM
admet-529	368	12	.	.	PUNCT
admet-529	369	1	[	[	X
admet-529	369	2	28	28	NUM
admet-529	369	3	]	]	X
admet-529	369	4	m.e	m.e	PROPN
admet-529	369	5	.	.	PROPN
admet-529	369	6	kavanagh	kavanagh	PROPN
admet-529	369	7	,	,	PUNCT
admet-529	369	8	m.r	m.r	PROPN
admet-529	369	9	.	.	PROPN
admet-529	369	10	doddareddy	doddareddy	ADJ
admet-529	369	11	,	,	PUNCT
admet-529	369	12	m.	m.	NOUN
admet-529	369	13	kassiou	kassiou	NOUN
admet-529	369	14	.	.	PUNCT
admet-529	370	1	the	the	DET
admet-529	370	2	development	development	NOUN
admet-529	370	3	of	of	ADP
admet-529	370	4	cns	cns	NOUN
admet-529	370	5	-	-	PUNCT
admet-529	370	6	active	active	ADJ
admet-529	370	7	lrrk2	lrrk2	NOUN
admet-529	370	8	inhibitors	inhibitor	NOUN
admet-529	370	9	using	use	VERB
admet-529	370	10	property	property	NOUN
admet-529	370	11	-	-	PUNCT
admet-529	370	12	directed	direct	VERB
admet-529	370	13	optimisation	optimisation	NOUN
admet-529	370	14	.	.	PUNCT
admet-529	371	1	bioorganic	bioorganic	PROPN
admet-529	371	2	&	&	CCONJ
admet-529	371	3	medicinal	medicinal	ADJ
admet-529	371	4	chemistry	chemistry	NOUN
admet-529	371	5	letters	letter	NOUN
admet-529	371	6	23	23	NUM
admet-529	371	7	(	(	PUNCT
admet-529	371	8	2013	2013	NUM
admet-529	371	9	)	)	PUNCT
admet-529	371	10	36903696	36903696	NUM
admet-529	371	11	.	.	PUNCT
admet-529	372	1	[	[	X
admet-529	372	2	29	29	NUM
admet-529	372	3	]	]	X
admet-529	372	4	m.p	m.p	PROPN
admet-529	372	5	.	.	PROPN
admet-529	372	6	deninno	deninno	PROPN
admet-529	372	7	,	,	PUNCT
admet-529	372	8	m.	m.	PROPN
admet-529	372	9	andrews	andrews	PROPN
admet-529	372	10	,	,	PUNCT
admet-529	372	11	a.s	a.s	PROPN
admet-529	372	12	.	.	PROPN
admet-529	372	13	bell	bell	PROPN
admet-529	372	14	,	,	PUNCT
admet-529	372	15	y.	y.	PROPN
admet-529	372	16	chen	chen	PROPN
admet-529	372	17	,	,	PUNCT
admet-529	372	18	c.	c.	PROPN
admet-529	372	19	eller	eller	PROPN
admet-529	372	20	-	-	PUNCT
admet-529	372	21	zarbo	zarbo	PROPN
admet-529	372	22	,	,	PUNCT
admet-529	372	23	n.	n.	PROPN
admet-529	372	24	eshelby	eshelby	PROPN
admet-529	372	25	,	,	PUNCT
admet-529	372	26	j.b	j.b	PROPN
admet-529	372	27	.	.	PUNCT
admet-529	373	1	etienne	etienne	PROPN
admet-529	373	2	,	,	PUNCT
admet-529	373	3	d.e	d.e	PROPN
admet-529	373	4	.	.	PROPN
admet-529	373	5	moore	moore	PROPN
admet-529	373	6	,	,	PUNCT
admet-529	373	7	m.j	m.j	PROPN
admet-529	373	8	.	.	PROPN
admet-529	373	9	palmer	palmer	PROPN
admet-529	373	10	,	,	PUNCT
admet-529	373	11	m.s	m.s	PROPN
admet-529	373	12	.	.	PROPN
admet-529	373	13	visser	visser	PROPN
admet-529	373	14	,	,	PUNCT
admet-529	373	15	l.j	l.j	PROPN
admet-529	373	16	.	.	PROPN
admet-529	373	17	yu	yu	PROPN
admet-529	373	18	,	,	PUNCT
admet-529	373	19	w.j	w.j	PROPN
admet-529	373	20	.	.	PROPN
admet-529	373	21	zavadoski	zavadoski	PROPN
admet-529	373	22	,	,	PUNCT
admet-529	373	23	e.	e.	PROPN
admet-529	373	24	michael	michael	PROPN
admet-529	373	25	gibbs	gibbs	PROPN
admet-529	373	26	.	.	PUNCT
admet-529	374	1	the	the	DET
admet-529	374	2	discovery	discovery	NOUN
admet-529	374	3	of	of	ADP
admet-529	374	4	potent	potent	ADJ
admet-529	374	5	,	,	PUNCT
admet-529	374	6	selective	selective	ADJ
admet-529	374	7	,	,	PUNCT
admet-529	374	8	and	and	CCONJ
admet-529	374	9	orally	orally	ADV
admet-529	374	10	bioavailable	bioavailable	ADJ
admet-529	374	11	pde9	pde9	NOUN
admet-529	374	12	inhibitors	inhibitor	NOUN
admet-529	374	13	as	as	ADP
admet-529	374	14	potential	potential	ADJ
admet-529	374	15	hypoglycemic	hypoglycemic	ADJ
admet-529	374	16	agents	agent	NOUN
admet-529	374	17	.	.	PUNCT
admet-529	375	1	bioorg	bioorg	PROPN
admet-529	375	2	med	med	PROPN
admet-529	375	3	chem	chem	NOUN
admet-529	375	4	lett	lett	NOUN
admet-529	375	5	19	19	NUM
admet-529	375	6	(	(	PUNCT
admet-529	375	7	2009	2009	NUM
admet-529	375	8	)	)	PUNCT
admet-529	375	9	2537	2537	NUM
admet-529	375	10	-	-	SYM
admet-529	375	11	2541	2541	NUM
admet-529	375	12	.	.	PUNCT
admet-529	376	1	g.h	g.h	PROPN
admet-529	376	2	.	.	PROPN
admet-529	376	3	goetz	goetz	PROPN
admet-529	376	4	and	and	CCONJ
admet-529	376	5	m.	m.	NOUN
admet-529	376	6	shalaeva	shalaeva	PROPN
admet-529	376	7	admet	admet	PROPN
admet-529	376	8	&	&	CCONJ
admet-529	376	9	dmpk	dmpk	PROPN
admet-529	376	10	6(2	6(2	NUM
admet-529	376	11	)	)	PUNCT
admet-529	376	12	(	(	PUNCT
admet-529	376	13	2018	2018	NUM
admet-529	376	14	)	)	PUNCT
admet-529	376	15	85	85	NUM
admet-529	376	16	-	-	SYM
admet-529	376	17	104	104	NUM
admet-529	376	18	100	100	NUM
admet-529	376	19	[	[	X
admet-529	376	20	30	30	NUM
admet-529	376	21	]	]	PUNCT
admet-529	376	22	z.	z.	PROPN
admet-529	376	23	rankovic	rankovic	PROPN
admet-529	376	24	.	.	PUNCT
admet-529	377	1	cns	cns	PROPN
admet-529	377	2	physicochemical	physicochemical	ADJ
admet-529	377	3	property	property	NOUN
admet-529	377	4	space	space	NOUN
admet-529	377	5	shaped	shape	VERB
admet-529	377	6	by	by	ADP
admet-529	377	7	a	a	DET
admet-529	377	8	diverse	diverse	ADJ
admet-529	377	9	set	set	NOUN
admet-529	377	10	of	of	ADP
admet-529	377	11	molecules	molecule	NOUN
admet-529	377	12	with	with	ADP
admet-529	377	13	experimentally	experimentally	ADV
admet-529	377	14	determined	determine	VERB
admet-529	377	15	exposure	exposure	NOUN
admet-529	377	16	in	in	ADP
admet-529	377	17	the	the	DET
admet-529	377	18	mouse	mouse	NOUN
admet-529	377	19	brain	brain	NOUN
admet-529	377	20	.	.	PUNCT
admet-529	378	1	j	j	PROPN
admet-529	378	2	med	med	PROPN
admet-529	378	3	chem	chem	NOUN
admet-529	378	4	60	60	NUM
admet-529	378	5	(	(	PUNCT
admet-529	378	6	2017	2017	NUM
admet-529	378	7	)	)	PUNCT
admet-529	378	8	5943	5943	NUM
admet-529	378	9	-	-	SYM
admet-529	378	10	5954	5954	NUM
admet-529	378	11	.	.	PUNCT
admet-529	379	1	[	[	X
admet-529	379	2	31	31	NUM
admet-529	379	3	]	]	X
admet-529	379	4	n.m	n.m	PROPN
admet-529	379	5	.	.	PROPN
admet-529	379	6	ahmad	ahmad	PROPN
admet-529	379	7	.	.	PUNCT
admet-529	380	1	solubility	solubility	NOUN
admet-529	380	2	-	-	PUNCT
admet-529	380	3	driven	drive	VERB
admet-529	380	4	lead	lead	NOUN
admet-529	380	5	optimisation	optimisation	NOUN
admet-529	380	6	:	:	PUNCT
admet-529	380	7	recent	recent	ADJ
admet-529	380	8	examples	example	NOUN
admet-529	380	9	and	and	CCONJ
admet-529	380	10	personal	personal	ADJ
admet-529	380	11	perspectives	perspective	NOUN
admet-529	380	12	.	.	PUNCT
admet-529	381	1	bioorganic	bioorganic	PROPN
admet-529	381	2	&	&	CCONJ
admet-529	381	3	medicinal	medicinal	ADJ
admet-529	381	4	chemistry	chemistry	NOUN
admet-529	381	5	letters	letter	NOUN
admet-529	381	6	26	26	NUM
admet-529	381	7	(	(	PUNCT
admet-529	381	8	2016	2016	NUM
admet-529	381	9	)	)	PUNCT
admet-529	381	10	2975	2975	NUM
admet-529	381	11	-	-	SYM
admet-529	381	12	2979	2979	NUM
admet-529	381	13	.	.	PUNCT
admet-529	382	1	[	[	X
admet-529	382	2	32	32	NUM
admet-529	382	3	]	]	X
admet-529	382	4	d.j	d.j	PROPN
admet-529	382	5	.	.	PROPN
admet-529	382	6	craik	craik	PROPN
admet-529	382	7	,	,	PUNCT
admet-529	382	8	d.p	d.p	PROPN
admet-529	382	9	.	.	PROPN
admet-529	382	10	fairlie	fairlie	PROPN
admet-529	382	11	,	,	PUNCT
admet-529	382	12	s.	s.	PROPN
admet-529	382	13	liras	liras	PROPN
admet-529	382	14	,	,	PUNCT
admet-529	382	15	d.	d.	PROPN
admet-529	382	16	price	price	NOUN
admet-529	382	17	.	.	PUNCT
admet-529	383	1	the	the	DET
admet-529	383	2	future	future	NOUN
admet-529	383	3	of	of	ADP
admet-529	383	4	peptide	peptide	NOUN
admet-529	383	5	-	-	PUNCT
admet-529	383	6	based	base	VERB
admet-529	383	7	drugs	drug	NOUN
admet-529	383	8	.	.	PUNCT
admet-529	384	1	chem	chem	NOUN
admet-529	384	2	biol	biol	PROPN
admet-529	384	3	drug	drug	PROPN
admet-529	384	4	des	des	X
admet-529	384	5	81	81	NUM
admet-529	384	6	(	(	PUNCT
admet-529	384	7	2013	2013	NUM
admet-529	384	8	)	)	PUNCT
admet-529	384	9	136	136	NUM
admet-529	384	10	-	-	SYM
admet-529	384	11	147	147	NUM
admet-529	384	12	.	.	PUNCT
admet-529	385	1	[	[	X
admet-529	385	2	33	33	NUM
admet-529	385	3	]	]	PUNCT
admet-529	385	4	k.	k.	NOUN
admet-529	385	5	fosgerau	fosgerau	PROPN
admet-529	385	6	,	,	PUNCT
admet-529	385	7	t.	t.	PROPN
admet-529	385	8	hoffmann	hoffmann	PROPN
admet-529	385	9	.	.	PUNCT
admet-529	386	1	peptide	peptide	NOUN
admet-529	386	2	therapeutics	therapeutic	NOUN
admet-529	386	3	:	:	PUNCT
admet-529	386	4	current	current	ADJ
admet-529	386	5	status	status	NOUN
admet-529	386	6	and	and	CCONJ
admet-529	386	7	future	future	ADJ
admet-529	386	8	directions	direction	NOUN
admet-529	386	9	.	.	PUNCT
admet-529	387	1	drug	drug	NOUN
admet-529	387	2	discovery	discovery	PROPN
admet-529	387	3	today	today	NOUN
admet-529	387	4	20	20	NUM
admet-529	387	5	(	(	PUNCT
admet-529	387	6	2015	2015	NUM
admet-529	387	7	)	)	PUNCT
admet-529	387	8	122	122	NUM
admet-529	387	9	-	-	SYM
admet-529	387	10	128	128	NUM
admet-529	387	11	.	.	PUNCT
admet-529	388	1	[	[	X
admet-529	388	2	34	34	NUM
admet-529	388	3	]	]	X
admet-529	388	4	m.e	m.e	PROPN
admet-529	388	5	.	.	PROPN
admet-529	388	6	bunnage	bunnage	PROPN
admet-529	388	7	,	,	PUNCT
admet-529	388	8	e.l.p	e.l.p	NOUN
admet-529	388	9	.	.	PUNCT
admet-529	389	1	chekler	chekler	PROPN
admet-529	389	2	,	,	PUNCT
admet-529	389	3	l.h	l.h	PROPN
admet-529	389	4	.	.	PROPN
admet-529	389	5	jones	jones	PROPN
admet-529	389	6	.	.	PUNCT
admet-529	390	1	target	target	NOUN
admet-529	390	2	validation	validation	NOUN
admet-529	390	3	using	use	VERB
admet-529	390	4	chemical	chemical	NOUN
admet-529	390	5	probes	probe	NOUN
admet-529	390	6	.	.	PUNCT
admet-529	391	1	nature	nature	NOUN
admet-529	391	2	chemical	chemical	NOUN
admet-529	391	3	biology	biology	NOUN
admet-529	391	4	9	9	NUM
admet-529	391	5	(	(	PUNCT
admet-529	391	6	2013	2013	NUM
admet-529	391	7	)	)	PUNCT
admet-529	391	8	195	195	NUM
admet-529	391	9	.	.	PUNCT
admet-529	392	1	[	[	X
admet-529	392	2	35	35	NUM
admet-529	392	3	]	]	X
admet-529	392	4	c.r	c.r	PROPN
admet-529	392	5	.	.	PROPN
admet-529	392	6	guimaraes	guimaraes	PROPN
admet-529	392	7	,	,	PUNCT
admet-529	392	8	a.m.	a.m.	PROPN
admet-529	392	9	mathiowetz	mathiowetz	PROPN
admet-529	392	10	,	,	PUNCT
admet-529	392	11	m.	m.	NOUN
admet-529	392	12	shalaeva	shalaeva	PROPN
admet-529	392	13	,	,	PUNCT
admet-529	392	14	g.	g.	PROPN
admet-529	392	15	goetz	goetz	PROPN
admet-529	392	16	,	,	PUNCT
admet-529	392	17	s.	s.	PROPN
admet-529	392	18	liras	liras	PROPN
admet-529	392	19	.	.	PUNCT
admet-529	393	1	use	use	NOUN
admet-529	393	2	of	of	ADP
admet-529	393	3	3d	3d	NUM
admet-529	393	4	properties	property	NOUN
admet-529	393	5	to	to	PART
admet-529	393	6	characterize	characterize	VERB
admet-529	393	7	beyond	beyond	ADP
admet-529	393	8	rule	rule	NOUN
admet-529	393	9	-	-	PUNCT
admet-529	393	10	of-5	of-5	NOUN
admet-529	393	11	property	property	NOUN
admet-529	393	12	space	space	NOUN
admet-529	393	13	for	for	ADP
admet-529	393	14	passive	passive	ADJ
admet-529	393	15	permeation	permeation	NOUN
admet-529	393	16	.	.	PUNCT
admet-529	394	1	journal	journal	PROPN
admet-529	394	2	of	of	ADP
admet-529	394	3	chemical	chemical	ADJ
admet-529	394	4	information	information	NOUN
admet-529	394	5	and	and	CCONJ
admet-529	394	6	modeling	model	VERB
admet-529	394	7	52	52	NUM
admet-529	394	8	(	(	PUNCT
admet-529	394	9	2012	2012	NUM
admet-529	394	10	)	)	PUNCT
admet-529	394	11	882	882	NUM
admet-529	394	12	-	-	SYM
admet-529	394	13	890	890	NUM
admet-529	394	14	.	.	PUNCT
admet-529	395	1	[	[	X
admet-529	395	2	36	36	NUM
admet-529	395	3	]	]	SYM
admet-529	395	4	b.c	b.c	PROPN
admet-529	395	5	.	.	PROPN
admet-529	395	6	doak	doak	PROPN
admet-529	395	7	,	,	PUNCT
admet-529	395	8	b.	b.	PROPN
admet-529	395	9	over	over	PROPN
admet-529	395	10	,	,	PUNCT
admet-529	395	11	f.	f.	PROPN
admet-529	395	12	giordanetto	giordanetto	PROPN
admet-529	395	13	,	,	PUNCT
admet-529	395	14	j.	j.	PROPN
admet-529	395	15	kihlberg	kihlberg	PROPN
admet-529	395	16	.	.	PUNCT
admet-529	396	1	oral	oral	ADJ
admet-529	396	2	druggable	druggable	ADJ
admet-529	396	3	space	space	NOUN
admet-529	396	4	beyond	beyond	ADP
admet-529	396	5	the	the	DET
admet-529	396	6	rule	rule	NOUN
admet-529	396	7	of	of	ADP
admet-529	396	8	5	5	NUM
admet-529	396	9	:	:	PUNCT
admet-529	396	10	insights	insight	NOUN
admet-529	396	11	from	from	ADP
admet-529	396	12	drugs	drug	NOUN
admet-529	396	13	and	and	CCONJ
admet-529	396	14	clinical	clinical	ADJ
admet-529	396	15	candidates	candidate	NOUN
admet-529	396	16	.	.	PUNCT
admet-529	397	1	chem	chem	NOUN
admet-529	397	2	biol	biol	NOUN
admet-529	397	3	21	21	NUM
admet-529	397	4	(	(	PUNCT
admet-529	397	5	2014	2014	NUM
admet-529	397	6	)	)	PUNCT
admet-529	397	7	1115	1115	NUM
admet-529	397	8	-	-	SYM
admet-529	397	9	1142	1142	NUM
admet-529	397	10	.	.	PUNCT
admet-529	398	1	[	[	X
admet-529	398	2	37	37	NUM
admet-529	398	3	]	]	X
admet-529	398	4	c.k	c.k	PROPN
admet-529	398	5	.	.	PROPN
admet-529	398	6	wang	wang	PROPN
admet-529	398	7	,	,	PUNCT
admet-529	398	8	s.e	s.e	PROPN
admet-529	398	9	.	.	PROPN
admet-529	398	10	northfield	northfield	PROPN
admet-529	398	11	,	,	PUNCT
admet-529	398	12	j.e	j.e	PROPN
admet-529	398	13	.	.	PROPN
admet-529	398	14	swedberg	swedberg	PROPN
admet-529	398	15	,	,	PUNCT
admet-529	398	16	b.	b.	PROPN
admet-529	398	17	colless	colless	PROPN
admet-529	398	18	,	,	PUNCT
admet-529	398	19	s.	s.	PROPN
admet-529	398	20	chaousis	chaousis	PROPN
admet-529	398	21	,	,	PUNCT
admet-529	398	22	d.a	d.a	PROPN
admet-529	398	23	.	.	PROPN
admet-529	398	24	price	price	NOUN
admet-529	398	25	,	,	PUNCT
admet-529	398	26	s.	s.	PROPN
admet-529	398	27	liras	liras	PROPN
admet-529	398	28	,	,	PUNCT
admet-529	398	29	d.j	d.j	PROPN
admet-529	398	30	.	.	PROPN
admet-529	398	31	craik	craik	NOUN
admet-529	398	32	.	.	PUNCT
admet-529	399	1	exploring	explore	VERB
admet-529	399	2	experimental	experimental	ADJ
admet-529	399	3	and	and	CCONJ
admet-529	399	4	computational	computational	ADJ
admet-529	399	5	markers	marker	NOUN
admet-529	399	6	of	of	ADP
admet-529	399	7	cyclic	cyclic	ADJ
admet-529	399	8	peptides	peptide	NOUN
admet-529	399	9	:	:	PUNCT
admet-529	399	10	charting	chart	VERB
admet-529	399	11	islands	island	NOUN
admet-529	399	12	of	of	ADP
admet-529	399	13	permeability	permeability	NOUN
admet-529	399	14	.	.	PUNCT
admet-529	400	1	eur	eur	PROPN
admet-529	400	2	j	j	PROPN
admet-529	400	3	med	med	PROPN
admet-529	400	4	chem	chem	NOUN
admet-529	400	5	97	97	NUM
admet-529	400	6	(	(	PUNCT
admet-529	400	7	2015	2015	NUM
admet-529	400	8	)	)	PUNCT
admet-529	400	9	202	202	NUM
admet-529	400	10	-	-	SYM
admet-529	400	11	213	213	NUM
admet-529	400	12	.	.	PUNCT
admet-529	401	1	[	[	X
admet-529	401	2	38	38	NUM
admet-529	401	3	]	]	SYM
admet-529	401	4	a.t	a.t	PROPN
admet-529	401	5	.	.	PROPN
admet-529	401	6	bockus	bockus	PROPN
admet-529	401	7	,	,	PUNCT
admet-529	401	8	k.w	k.w	PROPN
admet-529	401	9	.	.	PROPN
admet-529	401	10	lexa	lexa	PROPN
admet-529	401	11	,	,	PUNCT
admet-529	401	12	c.r	c.r	PROPN
admet-529	401	13	.	.	PROPN
admet-529	401	14	pye	pye	PROPN
admet-529	401	15	,	,	PUNCT
admet-529	401	16	a.s	a.s	PROPN
admet-529	401	17	.	.	PROPN
admet-529	401	18	kalgutkar	kalgutkar	PROPN
admet-529	401	19	,	,	PUNCT
admet-529	401	20	j.w	j.w	PROPN
admet-529	401	21	.	.	PROPN
admet-529	401	22	gardner	gardner	PROPN
admet-529	401	23	,	,	PUNCT
admet-529	401	24	k.c.r	k.c.r	PROPN
admet-529	401	25	.	.	PUNCT
admet-529	402	1	hund	hund	PROPN
admet-529	402	2	,	,	PUNCT
admet-529	402	3	w.m	w.m	PROPN
admet-529	402	4	.	.	PROPN
admet-529	402	5	hewitt	hewitt	PROPN
admet-529	402	6	,	,	PUNCT
admet-529	402	7	j.a	j.a	PROPN
admet-529	402	8	.	.	PROPN
admet-529	402	9	schwochert	schwochert	PROPN
admet-529	402	10	,	,	PUNCT
admet-529	402	11	e.	e.	PROPN
admet-529	402	12	glassey	glassey	PROPN
admet-529	402	13	,	,	PUNCT
admet-529	402	14	d.a	d.a	PROPN
admet-529	402	15	.	.	PROPN
admet-529	402	16	price	price	NOUN
admet-529	402	17	,	,	PUNCT
admet-529	402	18	a.m.	a.m.	PROPN
admet-529	402	19	mathiowetz	mathiowetz	PROPN
admet-529	402	20	,	,	PUNCT
admet-529	402	21	s.	s.	PROPN
admet-529	402	22	liras	liras	PROPN
admet-529	402	23	,	,	PUNCT
admet-529	402	24	m.p	m.p	PROPN
admet-529	402	25	.	.	PROPN
admet-529	402	26	jacobson	jacobson	PROPN
admet-529	402	27	,	,	PUNCT
admet-529	402	28	r.s	r.s	PROPN
admet-529	402	29	.	.	PROPN
admet-529	402	30	lokey	lokey	PROPN
admet-529	402	31	.	.	PUNCT
admet-529	403	1	probing	probe	VERB
admet-529	403	2	the	the	DET
admet-529	403	3	physicochemical	physicochemical	ADJ
admet-529	403	4	boundaries	boundary	NOUN
admet-529	403	5	of	of	ADP
admet-529	403	6	cell	cell	NOUN
admet-529	403	7	permeability	permeability	NOUN
admet-529	403	8	and	and	CCONJ
admet-529	403	9	oral	oral	ADJ
admet-529	403	10	bioavailability	bioavailability	NOUN
admet-529	403	11	in	in	ADP
admet-529	403	12	lipophilic	lipophilic	ADJ
admet-529	403	13	macrocycles	macrocycle	NOUN
admet-529	403	14	inspired	inspire	VERB
admet-529	403	15	by	by	ADP
admet-529	403	16	natural	natural	ADJ
admet-529	403	17	products	product	NOUN
admet-529	403	18	.	.	PUNCT
admet-529	404	1	journal	journal	NOUN
admet-529	404	2	of	of	ADP
admet-529	404	3	medicinal	medicinal	ADJ
admet-529	404	4	chemistry	chemistry	NOUN
admet-529	404	5	58	58	NUM
admet-529	404	6	(	(	PUNCT
admet-529	404	7	2015	2015	NUM
admet-529	404	8	)	)	PUNCT
admet-529	404	9	4581	4581	NUM
admet-529	404	10	-	-	SYM
admet-529	404	11	4589	4589	NUM
admet-529	404	12	.	.	PUNCT
admet-529	405	1	[	[	X
admet-529	405	2	39	39	NUM
admet-529	405	3	]	]	X
admet-529	405	4	c.r	c.r	PROPN
admet-529	405	5	.	.	PROPN
admet-529	405	6	pye	pye	PROPN
admet-529	405	7	,	,	PUNCT
admet-529	405	8	w.m	w.m	PROPN
admet-529	405	9	.	.	PROPN
admet-529	405	10	hewitt	hewitt	PROPN
admet-529	405	11	,	,	PUNCT
admet-529	405	12	j.a	j.a	PROPN
admet-529	405	13	.	.	PROPN
admet-529	405	14	schwochert	schwochert	PROPN
admet-529	405	15	,	,	PUNCT
admet-529	405	16	t.d	t.d	PROPN
admet-529	405	17	.	.	PUNCT
admet-529	405	18	haddad	haddad	PROPN
admet-529	405	19	,	,	PUNCT
admet-529	405	20	c.e	c.e	PROPN
admet-529	405	21	.	.	PROPN
admet-529	405	22	townsend	townsend	PROPN
admet-529	405	23	,	,	PUNCT
admet-529	405	24	l.	l.	PROPN
admet-529	405	25	etienne	etienne	PROPN
admet-529	405	26	,	,	PUNCT
admet-529	405	27	y.	y.	PROPN
admet-529	405	28	lao	lao	PROPN
admet-529	405	29	,	,	PUNCT
admet-529	405	30	c.	c.	PROPN
admet-529	405	31	limberakis	limberakis	PROPN
admet-529	405	32	,	,	PUNCT
admet-529	405	33	a.	a.	NOUN
admet-529	405	34	furukawa	furukawa	PROPN
admet-529	405	35	,	,	PUNCT
admet-529	405	36	a.m.	a.m.	PROPN
admet-529	405	37	mathiowetz	mathiowetz	PROPN
admet-529	405	38	,	,	PUNCT
admet-529	405	39	d.a	d.a	PROPN
admet-529	405	40	.	.	PROPN
admet-529	405	41	price	price	NOUN
admet-529	405	42	,	,	PUNCT
admet-529	405	43	s.	s.	PROPN
admet-529	405	44	liras	liras	PROPN
admet-529	405	45	,	,	PUNCT
admet-529	405	46	r.s	r.s	PROPN
admet-529	405	47	.	.	PROPN
admet-529	405	48	lokey	lokey	PROPN
admet-529	405	49	.	.	PUNCT
admet-529	406	1	non	non	ADJ
admet-529	406	2	-	-	ADJ
admet-529	406	3	classical	classical	ADJ
admet-529	406	4	size	size	NOUN
admet-529	406	5	dependence	dependence	NOUN
admet-529	406	6	of	of	ADP
admet-529	406	7	permeation	permeation	NOUN
admet-529	406	8	defines	define	NOUN
admet-529	406	9	bounds	bound	VERB
admet-529	406	10	for	for	ADP
admet-529	406	11	passive	passive	ADJ
admet-529	406	12	adsorption	adsorption	NOUN
admet-529	406	13	of	of	ADP
admet-529	406	14	large	large	ADJ
admet-529	406	15	drug	drug	NOUN
admet-529	406	16	molecules	molecule	NOUN
admet-529	406	17	.	.	PUNCT
admet-529	407	1	journal	journal	NOUN
admet-529	407	2	of	of	ADP
admet-529	407	3	medicinal	medicinal	ADJ
admet-529	407	4	chemistry	chemistry	NOUN
admet-529	407	5	(	(	PUNCT
admet-529	407	6	2017	2017	NUM
admet-529	407	7	)	)	PUNCT
admet-529	407	8	.	.	PUNCT
admet-529	408	1	[	[	X
admet-529	408	2	40	40	NUM
admet-529	408	3	]	]	PUNCT
admet-529	408	4	p.	p.	NOUN
admet-529	408	5	seiler	seiler	PROPN
admet-529	408	6	.	.	PUNCT
admet-529	409	1	interconversion	interconversion	NOUN
admet-529	409	2	of	of	ADP
admet-529	409	3	lipophilicities	lipophilicitie	NOUN
admet-529	409	4	from	from	ADP
admet-529	409	5	hydrocarbon	hydrocarbon	NOUN
admet-529	409	6	/	/	SYM
admet-529	409	7	water	water	NOUN
admet-529	409	8	systems	system	NOUN
admet-529	409	9	into	into	ADP
admet-529	409	10	the	the	DET
admet-529	409	11	octanol	octanol	NOUN
admet-529	409	12	/	/	SYM
admet-529	409	13	water	water	NOUN
admet-529	409	14	system	system	NOUN
admet-529	409	15	.	.	PUNCT
admet-529	410	1	eur	eur	PROPN
admet-529	410	2	j	j	PROPN
admet-529	410	3	med	med	PROPN
admet-529	410	4	chem	chem	NOUN
admet-529	410	5	39	39	NUM
admet-529	410	6	(	(	PUNCT
admet-529	410	7	1974	1974	NUM
admet-529	410	8	)	)	PUNCT
admet-529	410	9	473	473	NUM
admet-529	410	10	-	-	SYM
admet-529	410	11	479	479	NUM
admet-529	410	12	.	.	PUNCT
admet-529	411	1	[	[	X
admet-529	411	2	41	41	NUM
admet-529	411	3	]	]	X
admet-529	411	4	t.w	t.w	PROPN
admet-529	411	5	.	.	PROPN
admet-529	411	6	von	von	PROPN
admet-529	411	7	geldern	geldern	PROPN
admet-529	411	8	,	,	PUNCT
admet-529	411	9	d.j	d.j	PROPN
admet-529	411	10	.	.	PROPN
admet-529	411	11	hoffman	hoffman	PROPN
admet-529	411	12	,	,	PUNCT
admet-529	411	13	j.a	j.a	PROPN
admet-529	411	14	.	.	PROPN
admet-529	411	15	kester	kester	PROPN
admet-529	411	16	,	,	PUNCT
admet-529	411	17	h.n	h.n	PROPN
admet-529	411	18	.	.	PROPN
admet-529	411	19	nellans	nellans	PROPN
admet-529	411	20	,	,	PUNCT
admet-529	411	21	b.d	b.d	PROPN
admet-529	411	22	.	.	PROPN
admet-529	411	23	dayton	dayton	PROPN
admet-529	411	24	,	,	PUNCT
admet-529	411	25	s.v	s.v	PROPN
admet-529	411	26	.	.	PROPN
admet-529	411	27	calzadilla	calzadilla	PROPN
admet-529	411	28	,	,	PUNCT
admet-529	411	29	k.c	k.c	PROPN
admet-529	411	30	.	.	PROPN
admet-529	411	31	marsh	marsh	PROPN
admet-529	411	32	,	,	PUNCT
admet-529	411	33	l.	l.	PROPN
admet-529	411	34	hernandez	hernandez	PROPN
admet-529	411	35	,	,	PUNCT
admet-529	411	36	w.	w.	PROPN
admet-529	411	37	chiou	chiou	PROPN
admet-529	411	38	,	,	PUNCT
admet-529	411	39	d.b	d.b	PROPN
admet-529	411	40	.	.	PROPN
admet-529	411	41	dixon	dixon	PROPN
admet-529	411	42	,	,	PUNCT
admet-529	411	43	j.r	j.r	PROPN
admet-529	411	44	.	.	PROPN
admet-529	411	45	wu	wu	PROPN
admet-529	411	46	-	-	PUNCT
admet-529	411	47	wong	wong	PROPN
admet-529	411	48	,	,	PUNCT
admet-529	411	49	t.j	t.j	PROPN
admet-529	411	50	.	.	PROPN
admet-529	411	51	opgenorth	opgenorth	PROPN
admet-529	411	52	.	.	PUNCT
admet-529	412	1	azole	azole	PROPN
admet-529	412	2	endothelin	endothelin	PROPN
admet-529	412	3	antagonists	antagonist	NOUN
admet-529	412	4	.	.	PUNCT
admet-529	413	1	3	3	X
admet-529	413	2	.	.	X
admet-529	413	3	using	use	VERB
admet-529	413	4	δ	δ	PROPN
admet-529	413	5	log	log	VERB
admet-529	413	6	p	p	NOUN
admet-529	413	7	as	as	ADP
admet-529	413	8	a	a	DET
admet-529	413	9	tool	tool	NOUN
admet-529	413	10	to	to	PART
admet-529	413	11	improve	improve	VERB
admet-529	413	12	absorption	absorption	NOUN
admet-529	413	13	.	.	PUNCT
admet-529	414	1	journal	journal	PROPN
admet-529	414	2	of	of	ADP
admet-529	414	3	medicinal	medicinal	ADJ
admet-529	414	4	chemistry	chemistry	NOUN
admet-529	414	5	39	39	NUM
admet-529	414	6	(	(	PUNCT
admet-529	414	7	1996	1996	NUM
admet-529	414	8	)	)	PUNCT
admet-529	414	9	982	982	NUM
admet-529	414	10	-	-	SYM
admet-529	414	11	991	991	NUM
admet-529	414	12	.	.	PUNCT
admet-529	415	1	[	[	X
admet-529	415	2	42	42	NUM
admet-529	415	3	]	]	X
admet-529	415	4	r.c	r.c	PROPN
admet-529	415	5	.	.	PROPN
admet-529	415	6	young	young	PROPN
admet-529	415	7	,	,	PUNCT
admet-529	415	8	r.c	r.c	PROPN
admet-529	415	9	.	.	PROPN
admet-529	415	10	mitchell	mitchell	PROPN
admet-529	415	11	,	,	PUNCT
admet-529	415	12	t.h	t.h	PROPN
admet-529	415	13	.	.	PROPN
admet-529	415	14	brown	brown	PROPN
admet-529	415	15	,	,	PUNCT
admet-529	415	16	c.r	c.r	PROPN
admet-529	415	17	.	.	PROPN
admet-529	415	18	ganellin	ganellin	PROPN
admet-529	415	19	,	,	PUNCT
admet-529	415	20	r.	r.	PROPN
admet-529	415	21	griffiths	griffiths	PROPN
admet-529	415	22	,	,	PUNCT
admet-529	415	23	m.	m.	PROPN
admet-529	415	24	jones	jones	PROPN
admet-529	415	25	,	,	PUNCT
admet-529	415	26	k.k	k.k	PROPN
admet-529	415	27	.	.	PROPN
admet-529	415	28	rana	rana	PROPN
admet-529	415	29	,	,	PUNCT
admet-529	415	30	d.	d.	PROPN
admet-529	415	31	saunders	saunders	PROPN
admet-529	415	32	,	,	PUNCT
admet-529	415	33	i.r	i.r	PROPN
admet-529	415	34	.	.	PROPN
admet-529	415	35	smith	smith	PROPN
admet-529	415	36	.	.	PUNCT
admet-529	416	1	development	development	NOUN
admet-529	416	2	of	of	ADP
admet-529	416	3	a	a	DET
admet-529	416	4	new	new	ADJ
admet-529	416	5	physicochemical	physicochemical	ADJ
admet-529	416	6	model	model	NOUN
admet-529	416	7	for	for	ADP
admet-529	416	8	brain	brain	NOUN
admet-529	416	9	penetration	penetration	NOUN
admet-529	416	10	and	and	CCONJ
admet-529	416	11	its	its	PRON
admet-529	416	12	application	application	NOUN
admet-529	416	13	to	to	ADP
admet-529	416	14	the	the	DET
admet-529	416	15	design	design	NOUN
admet-529	416	16	of	of	ADP
admet-529	416	17	centrally	centrally	ADV
admet-529	416	18	acting	act	VERB
admet-529	416	19	h2	h2	NOUN
admet-529	416	20	receptor	receptor	NOUN
admet-529	416	21	histamine	histamine	NOUN
admet-529	416	22	antagonists	antagonist	NOUN
admet-529	416	23	.	.	PUNCT
admet-529	417	1	journal	journal	NOUN
admet-529	417	2	of	of	ADP
admet-529	417	3	medicinal	medicinal	ADJ
admet-529	417	4	chemistry	chemistry	NOUN
admet-529	417	5	31	31	NUM
admet-529	417	6	(	(	PUNCT
admet-529	417	7	1988	1988	NUM
admet-529	417	8	)	)	PUNCT
admet-529	417	9	656	656	NUM
admet-529	417	10	-	-	SYM
admet-529	417	11	671	671	NUM
admet-529	417	12	.	.	PUNCT
admet-529	418	1	[	[	X
admet-529	418	2	43	43	NUM
admet-529	418	3	]	]	X
admet-529	418	4	j.t	j.t	PROPN
admet-529	418	5	.	.	PROPN
admet-529	418	6	goodwin	goodwin	PROPN
admet-529	418	7	,	,	PUNCT
admet-529	418	8	r.a	r.a	PROPN
admet-529	418	9	.	.	PROPN
admet-529	418	10	conradi	conradi	PROPN
admet-529	418	11	,	,	PUNCT
admet-529	418	12	n.f	n.f	PROPN
admet-529	418	13	.	.	PROPN
admet-529	418	14	ho	ho	PROPN
admet-529	418	15	,	,	PUNCT
admet-529	418	16	p.s	p.s	PROPN
admet-529	418	17	.	.	PROPN
admet-529	418	18	burton	burton	PROPN
admet-529	418	19	.	.	PUNCT
admet-529	419	1	physicochemical	physicochemical	ADJ
admet-529	419	2	determinants	determinant	NOUN
admet-529	419	3	of	of	ADP
admet-529	419	4	passive	passive	ADJ
admet-529	419	5	membrane	membrane	NOUN
admet-529	419	6	permeability	permeability	NOUN
admet-529	419	7	:	:	PUNCT
admet-529	419	8	role	role	NOUN
admet-529	419	9	of	of	ADP
admet-529	419	10	solute	solute	ADJ
admet-529	419	11	hydrogen	hydrogen	NOUN
admet-529	419	12	-	-	PUNCT
admet-529	419	13	bonding	bonding	NOUN
admet-529	419	14	potential	potential	NOUN
admet-529	419	15	and	and	CCONJ
admet-529	419	16	volume	volume	NOUN
admet-529	419	17	.	.	PUNCT
admet-529	420	1	j	j	PROPN
admet-529	420	2	med	med	PROPN
admet-529	420	3	chem	chem	NOUN
admet-529	420	4	44	44	NUM
admet-529	420	5	(	(	PUNCT
admet-529	420	6	2001	2001	NUM
admet-529	420	7	)	)	PUNCT
admet-529	420	8	3721	3721	NUM
admet-529	420	9	-	-	PUNCT
admet-529	420	10	3729	3729	NUM
admet-529	420	11	.	.	PUNCT
admet-529	421	1	[	[	X
admet-529	421	2	44	44	NUM
admet-529	421	3	]	]	X
admet-529	421	4	m.h	m.h	PROPN
admet-529	421	5	.	.	PROPN
admet-529	421	6	abraham	abraham	PROPN
admet-529	421	7	,	,	PUNCT
admet-529	421	8	r.e	r.e	PROPN
admet-529	421	9	.	.	PROPN
admet-529	421	10	smith	smith	PROPN
admet-529	421	11	,	,	PUNCT
admet-529	421	12	r.	r.	PROPN
admet-529	421	13	luchtefeld	luchtefeld	PROPN
admet-529	421	14	,	,	PUNCT
admet-529	421	15	a.j	a.j	PROPN
admet-529	421	16	.	.	PROPN
admet-529	421	17	boorem	boorem	PROPN
admet-529	421	18	,	,	PUNCT
admet-529	421	19	r.	r.	PROPN
admet-529	421	20	luo	luo	PROPN
admet-529	421	21	,	,	PUNCT
admet-529	421	22	w.e	w.e	PROPN
admet-529	421	23	.	.	PROPN
admet-529	421	24	acree	acree	PROPN
admet-529	421	25	,	,	PUNCT
admet-529	421	26	jr	jr	PROPN
admet-529	421	27	.	.	PROPN
admet-529	421	28	prediction	prediction	NOUN
admet-529	421	29	of	of	ADP
admet-529	421	30	solubility	solubility	NOUN
admet-529	421	31	of	of	ADP
admet-529	421	32	drugs	drug	NOUN
admet-529	421	33	and	and	CCONJ
admet-529	421	34	other	other	ADJ
admet-529	421	35	compounds	compound	NOUN
admet-529	421	36	in	in	ADP
admet-529	421	37	organic	organic	ADJ
admet-529	421	38	solvents	solvent	NOUN
admet-529	421	39	.	.	PUNCT
admet-529	422	1	j	j	PROPN
admet-529	422	2	pharm	pharm	PROPN
admet-529	422	3	sci	sci	PROPN
admet-529	422	4	99	99	NUM
admet-529	422	5	(	(	PUNCT
admet-529	422	6	2010	2010	NUM
admet-529	422	7	)	)	PUNCT
admet-529	422	8	1500	1500	NUM
admet-529	422	9	-	-	SYM
admet-529	422	10	1515	1515	NUM
admet-529	422	11	.	.	PUNCT
admet-529	423	1	[	[	X
admet-529	423	2	45	45	NUM
admet-529	423	3	]	]	X
admet-529	423	4	g.	g.	PROPN
admet-529	423	5	gilli	gilli	PROPN
admet-529	423	6	,	,	PUNCT
admet-529	423	7	p.	p.	PROPN
admet-529	423	8	gilli	gilli	PROPN
admet-529	423	9	,	,	PUNCT
admet-529	423	10	the	the	DET
admet-529	423	11	nature	nature	NOUN
admet-529	423	12	of	of	ADP
admet-529	423	13	the	the	DET
admet-529	423	14	hydrogen	hydrogen	NOUN
admet-529	423	15	bond	bond	NOUN
admet-529	423	16	:	:	PUNCT
admet-529	423	17	outline	outline	NOUN
admet-529	423	18	of	of	ADP
admet-529	423	19	a	a	DET
admet-529	423	20	comprehensive	comprehensive	ADJ
admet-529	423	21	hydrogen	hydrogen	NOUN
admet-529	423	22	bond	bond	NOUN
admet-529	423	23	theory	theory	NOUN
admet-529	423	24	oxford	oxford	PROPN
admet-529	423	25	university	university	PROPN
admet-529	423	26	press	press	NOUN
admet-529	423	27	,	,	PUNCT
admet-529	423	28	new	new	ADJ
admet-529	423	29	york2009	york2009	PROPN
admet-529	423	30	.	.	PUNCT
admet-529	424	1	[	[	X
admet-529	424	2	46	46	NUM
admet-529	424	3	]	]	PUNCT
admet-529	424	4	m.	m.	NOUN
admet-529	424	5	shalaeva	shalaeva	PROPN
admet-529	424	6	,	,	PUNCT
admet-529	424	7	g.	g.	PROPN
admet-529	424	8	caron	caron	PROPN
admet-529	424	9	,	,	PUNCT
admet-529	424	10	y.a	y.a	PROPN
admet-529	424	11	.	.	PROPN
admet-529	424	12	abramov	abramov	PROPN
admet-529	424	13	,	,	PUNCT
admet-529	424	14	t.n	t.n	PROPN
admet-529	424	15	.	.	PROPN
admet-529	424	16	o’connell	o’connell	PROPN
admet-529	424	17	,	,	PUNCT
admet-529	424	18	m.s	m.s	PROPN
admet-529	424	19	.	.	PROPN
admet-529	424	20	plummer	plummer	PROPN
admet-529	424	21	,	,	PUNCT
admet-529	424	22	g.	g.	PROPN
admet-529	424	23	yalamanchi	yalamanchi	PROPN
admet-529	424	24	,	,	PUNCT
admet-529	424	25	k.a	k.a	PROPN
admet-529	424	26	.	.	PROPN
admet-529	424	27	farley	farley	PROPN
admet-529	424	28	,	,	PUNCT
admet-529	424	29	g.h	g.h	PROPN
admet-529	424	30	.	.	PROPN
admet-529	424	31	goetz	goetz	PROPN
admet-529	424	32	,	,	PUNCT
admet-529	424	33	l.	l.	PROPN
admet-529	424	34	philippe	philippe	PROPN
admet-529	424	35	,	,	PUNCT
admet-529	424	36	m.j	m.j	PROPN
admet-529	424	37	.	.	PROPN
admet-529	424	38	shapiro	shapiro	PROPN
admet-529	424	39	.	.	PUNCT
admet-529	425	1	integrating	integrate	VERB
admet-529	425	2	intramolecular	intramolecular	ADJ
admet-529	425	3	hydrogen	hydrogen	NOUN
admet-529	425	4	bonding	bonding	NOUN
admet-529	425	5	(	(	PUNCT
admet-529	425	6	imhb	imhb	ADJ
admet-529	425	7	)	)	PUNCT
admet-529	425	8	considerations	consideration	NOUN
admet-529	425	9	in	in	ADP
admet-529	425	10	drug	drug	NOUN
admet-529	425	11	discovery	discovery	NOUN
admet-529	425	12	using	use	VERB
admet-529	425	13	δlogp	δlogp	NOUN
admet-529	425	14	as	as	ADP
admet-529	425	15	a	a	DET
admet-529	425	16	tool	tool	NOUN
admet-529	425	17	.	.	PUNCT
admet-529	426	1	journal	journal	NOUN
admet-529	426	2	of	of	ADP
admet-529	426	3	medicinal	medicinal	ADJ
admet-529	426	4	chemistry	chemistry	NOUN
admet-529	426	5	56	56	NUM
admet-529	426	6	(	(	PUNCT
admet-529	426	7	2013	2013	NUM
admet-529	426	8	)	)	PUNCT
admet-529	426	9	4870	4870	NUM
admet-529	426	10	-	-	SYM
admet-529	426	11	4879	4879	NUM
admet-529	426	12	.	.	PUNCT
admet-529	427	1	[	[	X
admet-529	427	2	47	47	NUM
admet-529	427	3	]	]	X
admet-529	427	4	c.k	c.k	PROPN
admet-529	427	5	.	.	PROPN
admet-529	427	6	wittekindt	wittekindt	PROPN
admet-529	427	7	,	,	PUNCT
admet-529	427	8	a.	a.	PROPN
admet-529	427	9	cosmo	cosmo	PROPN
admet-529	427	10	-	-	PUNCT
admet-529	427	11	rs	rs	PROPN
admet-529	427	12	as	as	ADP
admet-529	427	13	a	a	DET
admet-529	427	14	predictive	predictive	ADJ
admet-529	427	15	tool	tool	NOUN
admet-529	427	16	for	for	ADP
admet-529	427	17	lipophilicity	lipophilicity	NOUN
admet-529	427	18	.	.	PUNCT
admet-529	428	1	qsar	qsar	NOUN
admet-529	428	2	comb	comb	NOUN
admet-529	428	3	.	.	PUNCT
admet-529	429	1	sci	sci	PROPN
admet-529	429	2	.	.	PROPN
admet-529	429	3	28	28	NUM
admet-529	429	4	(	(	PUNCT
admet-529	429	5	2009	2009	NUM
admet-529	429	6	)	)	PUNCT
admet-529	429	7	874−877	874−877	NUM
admet-529	429	8	.	.	PUNCT
admet-529	429	9	admet	admet	PROPN
admet-529	429	10	&	&	CCONJ
admet-529	429	11	dmpk	dmpk	PROPN
admet-529	429	12	6(2	6(2	NUM
admet-529	429	13	)	)	PUNCT
admet-529	429	14	(	(	PUNCT
admet-529	429	15	2018	2018	NUM
admet-529	429	16	)	)	PUNCT
admet-529	429	17	85	85	NUM
admet-529	429	18	-	-	SYM
admet-529	429	19	104	104	NUM
admet-529	429	20	leveraging	leverage	VERB
admet-529	429	21	chromatography	chromatography	NOUN
admet-529	429	22	physchem	physchem	NOUN
admet-529	429	23	properties	property	NOUN
admet-529	429	24	in	in	ADP
admet-529	429	25	drug	drug	NOUN
admet-529	429	26	design	design	NOUN
admet-529	429	27	doi	doi	NOUN
admet-529	429	28	:	:	PUNCT
admet-529	429	29	10.5599	10.5599	NUM
admet-529	429	30	/	/	SYM
admet-529	429	31	admet.529	admet.529	NOUN
admet-529	429	32	101	101	NUM
admet-529	430	1	[	[	X
admet-529	430	2	48	48	NUM
admet-529	430	3	]	]	X
admet-529	430	4	g.	g.	PROPN
admet-529	430	5	caron	caron	PROPN
admet-529	430	6	,	,	PUNCT
admet-529	430	7	m.	m.	NOUN
admet-529	430	8	vallaro	vallaro	NOUN
admet-529	430	9	,	,	PUNCT
admet-529	430	10	g.	g.	PROPN
admet-529	430	11	ermondi	ermondi	PROPN
admet-529	430	12	,	,	PUNCT
admet-529	430	13	g.h	g.h	PROPN
admet-529	430	14	.	.	PROPN
admet-529	430	15	goetz	goetz	PROPN
admet-529	430	16	,	,	PUNCT
admet-529	430	17	y.a	y.a	PROPN
admet-529	430	18	.	.	PROPN
admet-529	430	19	abramov	abramov	PROPN
admet-529	430	20	,	,	PUNCT
admet-529	430	21	l.	l.	PROPN
admet-529	430	22	philippe	philippe	PROPN
admet-529	430	23	,	,	PUNCT
admet-529	430	24	m.	m.	NOUN
admet-529	430	25	shalaeva	shalaeva	PROPN
admet-529	430	26	.	.	PUNCT
admet-529	431	1	a	a	DET
admet-529	431	2	fast	fast	ADJ
admet-529	431	3	chromatographic	chromatographic	ADJ
admet-529	431	4	method	method	NOUN
admet-529	431	5	for	for	ADP
admet-529	431	6	estimating	estimate	VERB
admet-529	431	7	lipophilicity	lipophilicity	NOUN
admet-529	431	8	and	and	CCONJ
admet-529	431	9	ionization	ionization	NOUN
admet-529	431	10	in	in	ADP
admet-529	431	11	nonpolar	nonpolar	ADJ
admet-529	431	12	membrane	membrane	NOUN
admet-529	431	13	-	-	PUNCT
admet-529	431	14	like	like	ADJ
admet-529	431	15	environment	environment	NOUN
admet-529	431	16	.	.	PUNCT
admet-529	432	1	molecular	molecular	ADJ
admet-529	432	2	pharmaceutics	pharmaceutic	NOUN
admet-529	432	3	13	13	NUM
admet-529	432	4	(	(	PUNCT
admet-529	432	5	2016	2016	NUM
admet-529	432	6	)	)	PUNCT
admet-529	432	7	1100	1100	NUM
admet-529	432	8	-	-	SYM
admet-529	432	9	1110	1110	NUM
admet-529	432	10	.	.	PUNCT
admet-529	433	1	[	[	X
admet-529	433	2	49	49	NUM
admet-529	433	3	]	]	PUNCT
admet-529	433	4	p.	p.	PROPN
admet-529	433	5	saha	saha	PROPN
admet-529	433	6	,	,	PUNCT
admet-529	433	7	j.h	j.h	PROPN
admet-529	433	8	.	.	PROPN
admet-529	433	9	kou	kou	PROPN
admet-529	433	10	.	.	PUNCT
admet-529	434	1	effect	effect	NOUN
admet-529	434	2	of	of	ADP
admet-529	434	3	solubilizing	solubilize	VERB
admet-529	434	4	excipients	excipient	NOUN
admet-529	434	5	on	on	ADP
admet-529	434	6	permeation	permeation	NOUN
admet-529	434	7	of	of	ADP
admet-529	434	8	poorly	poorly	ADV
admet-529	434	9	water	water	NOUN
admet-529	434	10	-	-	PUNCT
admet-529	434	11	soluble	soluble	ADJ
admet-529	434	12	compounds	compound	NOUN
admet-529	434	13	across	across	ADP
admet-529	434	14	caco-2	caco-2	NUM
admet-529	434	15	cell	cell	NOUN
admet-529	434	16	monolayers	monolayer	NOUN
admet-529	434	17	.	.	PUNCT
admet-529	435	1	european	european	PROPN
admet-529	435	2	journal	journal	PROPN
admet-529	435	3	of	of	ADP
admet-529	435	4	pharmaceutics	pharmaceutic	NOUN
admet-529	435	5	and	and	CCONJ
admet-529	435	6	biopharmaceutics	biopharmaceutic	NOUN
admet-529	435	7	50	50	NUM
admet-529	435	8	(	(	PUNCT
admet-529	435	9	2000	2000	NUM
admet-529	435	10	)	)	PUNCT
admet-529	435	11	403	403	NUM
admet-529	435	12	-	-	SYM
admet-529	435	13	411	411	NUM
admet-529	435	14	.	.	PUNCT
admet-529	436	1	[	[	X
admet-529	436	2	50	50	NUM
admet-529	436	3	]	]	PUNCT
admet-529	436	4	k.	k.	PROPN
admet-529	436	5	futatsugi	futatsugi	PROPN
admet-529	436	6	,	,	PUNCT
admet-529	436	7	k.b	k.b	PROPN
admet-529	436	8	.	.	PROPN
admet-529	436	9	bahnck	bahnck	PROPN
admet-529	436	10	,	,	PUNCT
admet-529	436	11	m.b	m.b	PROPN
admet-529	436	12	.	.	PROPN
admet-529	436	13	brenner	brenner	PROPN
admet-529	436	14	,	,	PUNCT
admet-529	436	15	j.	j.	PROPN
admet-529	436	16	buxton	buxton	PROPN
admet-529	436	17	,	,	PUNCT
admet-529	436	18	j.e	j.e	PROPN
admet-529	436	19	.	.	PROPN
admet-529	436	20	chin	chin	PROPN
admet-529	436	21	,	,	PUNCT
admet-529	436	22	s.b	s.b	PROPN
admet-529	436	23	.	.	PROPN
admet-529	436	24	coffey	coffey	PROPN
admet-529	436	25	,	,	PUNCT
admet-529	436	26	j.	j.	PROPN
admet-529	436	27	dubins	dubins	PROPN
admet-529	436	28	,	,	PUNCT
admet-529	436	29	d.	d.	PROPN
admet-529	436	30	flynn	flynn	PROPN
admet-529	436	31	,	,	PUNCT
admet-529	436	32	d.	d.	PROPN
admet-529	436	33	gautreau	gautreau	PROPN
admet-529	436	34	,	,	PUNCT
admet-529	436	35	a.	a.	PROPN
admet-529	436	36	guzman	guzman	PROPN
admet-529	436	37	-	-	PUNCT
admet-529	436	38	perez	perez	PROPN
admet-529	436	39	,	,	PUNCT
admet-529	436	40	j.r	j.r	PROPN
admet-529	436	41	.	.	PROPN
admet-529	436	42	hadcock	hadcock	PROPN
admet-529	436	43	,	,	PUNCT
admet-529	436	44	d.	d.	PROPN
admet-529	436	45	hepworth	hepworth	PROPN
admet-529	436	46	,	,	PUNCT
admet-529	436	47	m.	m.	NOUN
admet-529	436	48	herr	herr	PROPN
admet-529	436	49	,	,	PUNCT
admet-529	436	50	t.	t.	PROPN
admet-529	436	51	hinchey	hinchey	PROPN
admet-529	436	52	,	,	PUNCT
admet-529	436	53	a.m.	a.m.	PROPN
admet-529	436	54	janssen	janssen	PROPN
admet-529	436	55	,	,	PUNCT
admet-529	436	56	s.m	s.m	PROPN
admet-529	436	57	.	.	PROPN
admet-529	436	58	jennings	jennings	PROPN
admet-529	436	59	,	,	PUNCT
admet-529	436	60	w.	w.	PROPN
admet-529	436	61	jiao	jiao	PROPN
admet-529	436	62	,	,	PUNCT
admet-529	436	63	s.y	s.y	PROPN
admet-529	436	64	.	.	PROPN
admet-529	436	65	lavergne	lavergne	PROPN
admet-529	436	66	,	,	PUNCT
admet-529	436	67	b.	b.	PROPN
admet-529	436	68	li	li	PROPN
admet-529	436	69	,	,	PUNCT
admet-529	436	70	m.	m.	PROPN
admet-529	436	71	li	li	PROPN
admet-529	436	72	,	,	PUNCT
admet-529	436	73	m.j	m.j	PROPN
admet-529	436	74	.	.	PROPN
admet-529	436	75	munchhof	munchhof	PROPN
admet-529	436	76	,	,	PUNCT
admet-529	437	1	s.t.m	s.t.m	PROPN
admet-529	437	2	.	.	PUNCT
admet-529	437	3	orr	orr	PROPN
admet-529	437	4	,	,	PUNCT
admet-529	437	5	d.w	d.w	PROPN
admet-529	437	6	.	.	PROPN
admet-529	437	7	piotrowski	piotrowski	PROPN
admet-529	437	8	,	,	PUNCT
admet-529	437	9	n.s	n.s	PROPN
admet-529	437	10	.	.	PROPN
admet-529	437	11	roush	roush	PROPN
admet-529	437	12	,	,	PUNCT
admet-529	437	13	m.	m.	NOUN
admet-529	437	14	sammons	sammons	PROPN
admet-529	437	15	,	,	PUNCT
admet-529	437	16	b.d	b.d	PROPN
admet-529	437	17	.	.	PROPN
admet-529	437	18	stevens	stevens	PROPN
admet-529	437	19	,	,	PUNCT
admet-529	437	20	g.	g.	PROPN
admet-529	437	21	storer	storer	PROPN
admet-529	437	22	,	,	PUNCT
admet-529	437	23	j.	j.	PROPN
admet-529	437	24	wang	wang	PROPN
admet-529	437	25	,	,	PUNCT
admet-529	437	26	j.s	j.s	PROPN
admet-529	437	27	.	.	PROPN
admet-529	437	28	warmus	warmus	PROPN
admet-529	437	29	,	,	PUNCT
admet-529	437	30	l.	l.	PROPN
admet-529	437	31	wei	wei	PROPN
admet-529	437	32	,	,	PUNCT
admet-529	437	33	a.c	a.c	PROPN
admet-529	437	34	.	.	PROPN
admet-529	437	35	wolford	wolford	PROPN
admet-529	437	36	.	.	PUNCT
admet-529	438	1	optimization	optimization	NOUN
admet-529	438	2	of	of	ADP
admet-529	438	3	triazole	triazole	NOUN
admet-529	438	4	-	-	PUNCT
admet-529	438	5	based	base	VERB
admet-529	438	6	tgr5	tgr5	NOUN
admet-529	438	7	agonists	agonist	NOUN
admet-529	438	8	towards	towards	ADP
admet-529	438	9	orally	orally	ADV
admet-529	438	10	available	available	ADJ
admet-529	438	11	agents	agent	NOUN
admet-529	438	12	.	.	PUNCT
admet-529	439	1	medchemcomm	medchemcomm	NOUN
admet-529	439	2	4	4	NUM
admet-529	439	3	(	(	PUNCT
admet-529	439	4	2013	2013	NUM
admet-529	439	5	)	)	PUNCT
admet-529	439	6	205	205	NUM
admet-529	439	7	-	-	SYM
admet-529	439	8	210	210	NUM
admet-529	439	9	.	.	PUNCT
admet-529	440	1	[	[	X
admet-529	440	2	51	51	NUM
admet-529	440	3	]	]	X
admet-529	440	4	m.j	m.j	PROPN
admet-529	440	5	.	.	PROPN
admet-529	440	6	waring	waring	PROPN
admet-529	440	7	,	,	PUNCT
admet-529	440	8	j.	j.	PROPN
admet-529	440	9	arrowsmith	arrowsmith	PROPN
admet-529	440	10	,	,	PUNCT
admet-529	440	11	a.r	a.r	PROPN
admet-529	440	12	.	.	PROPN
admet-529	440	13	leach	leach	NOUN
admet-529	440	14	,	,	PUNCT
admet-529	440	15	p.d	p.d	PROPN
admet-529	440	16	.	.	PROPN
admet-529	440	17	leeson	leeson	PROPN
admet-529	440	18	,	,	PUNCT
admet-529	440	19	s.	s.	PROPN
admet-529	440	20	mandrell	mandrell	PROPN
admet-529	440	21	,	,	PUNCT
admet-529	440	22	r.m	r.m	PROPN
admet-529	440	23	.	.	PROPN
admet-529	440	24	owen	owen	PROPN
admet-529	440	25	,	,	PUNCT
admet-529	440	26	g.	g.	PROPN
admet-529	440	27	pairaudeau	pairaudeau	PROPN
admet-529	440	28	,	,	PUNCT
admet-529	440	29	w.d	w.d	PROPN
admet-529	440	30	.	.	PROPN
admet-529	440	31	pennie	pennie	PROPN
admet-529	440	32	,	,	PUNCT
admet-529	440	33	s.d	s.d	PROPN
admet-529	440	34	.	.	PROPN
admet-529	440	35	pickett	pickett	PROPN
admet-529	440	36	,	,	PUNCT
admet-529	440	37	j.	j.	PROPN
admet-529	440	38	wang	wang	PROPN
admet-529	440	39	,	,	PUNCT
admet-529	440	40	o.	o.	PROPN
admet-529	440	41	wallace	wallace	PROPN
admet-529	440	42	,	,	PUNCT
admet-529	440	43	a.	a.	PROPN
admet-529	440	44	weir	weir	PROPN
admet-529	440	45	.	.	PUNCT
admet-529	441	1	an	an	DET
admet-529	441	2	analysis	analysis	NOUN
admet-529	441	3	of	of	ADP
admet-529	441	4	the	the	DET
admet-529	441	5	attrition	attrition	NOUN
admet-529	441	6	of	of	ADP
admet-529	441	7	drug	drug	NOUN
admet-529	441	8	candidates	candidate	NOUN
admet-529	441	9	from	from	ADP
admet-529	441	10	four	four	NUM
admet-529	441	11	major	major	ADJ
admet-529	441	12	pharmaceutical	pharmaceutical	ADJ
admet-529	441	13	companies	company	NOUN
admet-529	441	14	.	.	PUNCT
admet-529	442	1	nature	nature	NOUN
admet-529	442	2	reviews	review	VERB
admet-529	442	3	drug	drug	NOUN
admet-529	442	4	discovery	discovery	NOUN
admet-529	442	5	14	14	NUM
admet-529	442	6	(	(	PUNCT
admet-529	442	7	2015	2015	NUM
admet-529	442	8	)	)	PUNCT
admet-529	442	9	475	475	NUM
admet-529	442	10	.	.	PUNCT
admet-529	443	1	[	[	X
admet-529	443	2	52	52	NUM
admet-529	443	3	]	]	SYM
admet-529	443	4	j.d	j.d	PROPN
admet-529	443	5	.	.	PROPN
admet-529	443	6	hughes	hughes	PROPN
admet-529	443	7	,	,	PUNCT
admet-529	443	8	j.	j.	PROPN
admet-529	443	9	blagg	blagg	PROPN
admet-529	443	10	,	,	PUNCT
admet-529	443	11	d.a	d.a	PROPN
admet-529	443	12	.	.	PROPN
admet-529	443	13	price	price	NOUN
admet-529	443	14	,	,	PUNCT
admet-529	443	15	s.	s.	PROPN
admet-529	443	16	bailey	bailey	PROPN
admet-529	443	17	,	,	PUNCT
admet-529	443	18	g.a	g.a	PROPN
admet-529	443	19	.	.	PROPN
admet-529	443	20	decrescenzo	decrescenzo	PROPN
admet-529	443	21	,	,	PUNCT
admet-529	443	22	r.v	r.v	PROPN
admet-529	443	23	.	.	PROPN
admet-529	443	24	devraj	devraj	PROPN
admet-529	443	25	,	,	PUNCT
admet-529	443	26	e.	e.	PROPN
admet-529	443	27	ellsworth	ellsworth	PROPN
admet-529	443	28	,	,	PUNCT
admet-529	443	29	y.m	y.m	PROPN
admet-529	443	30	.	.	PROPN
admet-529	443	31	fobian	fobian	PROPN
admet-529	443	32	,	,	PUNCT
admet-529	443	33	m.e	m.e	PROPN
admet-529	443	34	.	.	PROPN
admet-529	443	35	gibbs	gibbs	PROPN
admet-529	443	36	,	,	PUNCT
admet-529	443	37	r.w	r.w	PROPN
admet-529	443	38	.	.	PROPN
admet-529	443	39	gilles	gilles	PROPN
admet-529	443	40	,	,	PUNCT
admet-529	443	41	n.	n.	PROPN
admet-529	443	42	greene	greene	PROPN
admet-529	443	43	,	,	PUNCT
admet-529	443	44	e.	e.	PROPN
admet-529	443	45	huang	huang	PROPN
admet-529	443	46	,	,	PUNCT
admet-529	443	47	t.	t.	PROPN
admet-529	443	48	krieger	krieger	PROPN
admet-529	443	49	-	-	PUNCT
admet-529	443	50	burke	burke	PROPN
admet-529	443	51	,	,	PUNCT
admet-529	443	52	j.	j.	PROPN
admet-529	443	53	loesel	loesel	PROPN
admet-529	443	54	,	,	PUNCT
admet-529	443	55	t.	t.	NOUN
admet-529	443	56	wager	wager	NOUN
admet-529	443	57	,	,	PUNCT
admet-529	443	58	l.	l.	PROPN
admet-529	443	59	whiteley	whiteley	PROPN
admet-529	443	60	,	,	PUNCT
admet-529	443	61	y.	y.	PROPN
admet-529	443	62	zhang	zhang	PROPN
admet-529	443	63	.	.	PUNCT
admet-529	444	1	physiochemical	physiochemical	ADJ
admet-529	444	2	drug	drug	NOUN
admet-529	444	3	properties	property	NOUN
admet-529	444	4	associated	associate	VERB
admet-529	444	5	with	with	ADP
admet-529	444	6	in	in	ADP
admet-529	444	7	vivo	vivo	ADJ
admet-529	444	8	toxicological	toxicological	ADJ
admet-529	444	9	outcomes	outcome	NOUN
admet-529	444	10	.	.	PUNCT
admet-529	445	1	bioorg	bioorg	PROPN
admet-529	445	2	med	med	PROPN
admet-529	445	3	chem	chem	NOUN
admet-529	445	4	lett	lett	NOUN
admet-529	445	5	18	18	NUM
admet-529	445	6	(	(	PUNCT
admet-529	445	7	2008	2008	NUM
admet-529	445	8	)	)	PUNCT
admet-529	445	9	4872	4872	NUM
admet-529	445	10	-	-	SYM
admet-529	445	11	4875	4875	NUM
admet-529	445	12	.	.	PUNCT
admet-529	446	1	[	[	X
admet-529	446	2	53	53	NUM
admet-529	446	3	]	]	SYM
admet-529	446	4	d.a	d.a	PROPN
admet-529	446	5	.	.	PROPN
admet-529	446	6	price	price	NOUN
admet-529	446	7	,	,	PUNCT
admet-529	446	8	j.	j.	PROPN
admet-529	446	9	blagg	blagg	PROPN
admet-529	446	10	,	,	PUNCT
admet-529	446	11	l.	l.	PROPN
admet-529	446	12	jones	jones	PROPN
admet-529	446	13	,	,	PUNCT
admet-529	446	14	n.	n.	PROPN
admet-529	446	15	greene	greene	PROPN
admet-529	446	16	,	,	PUNCT
admet-529	446	17	t.	t.	NOUN
admet-529	446	18	wager	wager	NOUN
admet-529	446	19	.	.	PUNCT
admet-529	447	1	physicochemical	physicochemical	ADJ
admet-529	447	2	drug	drug	NOUN
admet-529	447	3	properties	property	NOUN
admet-529	447	4	associated	associate	VERB
admet-529	447	5	with	with	ADP
admet-529	447	6	in	in	ADP
admet-529	447	7	vivo	vivo	ADJ
admet-529	447	8	toxicological	toxicological	ADJ
admet-529	447	9	outcomes	outcome	NOUN
admet-529	447	10	:	:	PUNCT
admet-529	447	11	a	a	DET
admet-529	447	12	review	review	NOUN
admet-529	447	13	.	.	PUNCT
admet-529	448	1	expert	expert	NOUN
admet-529	448	2	opin	opin	NOUN
admet-529	448	3	drug	drug	NOUN
admet-529	448	4	metab	metab	NOUN
admet-529	448	5	toxicol	toxicol	NOUN
admet-529	448	6	5	5	NUM
admet-529	448	7	(	(	PUNCT
admet-529	448	8	2009	2009	NUM
admet-529	448	9	)	)	PUNCT
admet-529	448	10	921	921	NUM
admet-529	448	11	-	-	SYM
admet-529	448	12	931	931	NUM
admet-529	448	13	.	.	PUNCT
admet-529	449	1	[	[	X
admet-529	449	2	54	54	NUM
admet-529	449	3	]	]	SYM
admet-529	449	4	m.c	m.c	PROPN
admet-529	449	5	.	.	PROPN
admet-529	449	6	wenlock	wenlock	PROPN
admet-529	449	7	.	.	PUNCT
admet-529	450	1	designing	design	VERB
admet-529	450	2	safer	safe	ADJ
admet-529	450	3	oral	oral	ADJ
admet-529	450	4	drugs	drug	NOUN
admet-529	450	5	.	.	PUNCT
admet-529	451	1	medchemcomm	medchemcomm	NOUN
admet-529	451	2	8	8	NUM
admet-529	451	3	(	(	PUNCT
admet-529	451	4	2017	2017	NUM
admet-529	451	5	)	)	PUNCT
admet-529	451	6	571	571	NUM
admet-529	451	7	-	-	SYM
admet-529	451	8	577	577	NUM
admet-529	451	9	.	.	PUNCT
admet-529	452	1	[	[	X
admet-529	452	2	55	55	NUM
admet-529	452	3	]	]	X
admet-529	452	4	f.	f.	PROPN
admet-529	452	5	lombardo	lombardo	PROPN
admet-529	452	6	,	,	PUNCT
admet-529	452	7	m.y	m.y	PROPN
admet-529	452	8	.	.	PROPN
admet-529	452	9	shalaeva	shalaeva	PROPN
admet-529	452	10	,	,	PUNCT
admet-529	452	11	k.a	k.a	PROPN
admet-529	452	12	.	.	PROPN
admet-529	452	13	tupper	tupper	PROPN
admet-529	452	14	,	,	PUNCT
admet-529	452	15	f.	f.	PROPN
admet-529	452	16	gao	gao	PROPN
admet-529	452	17	,	,	PUNCT
admet-529	452	18	m.h	m.h	PROPN
admet-529	452	19	.	.	PROPN
admet-529	452	20	abraham	abraham	PROPN
admet-529	452	21	.	.	PUNCT
admet-529	453	1	elogpoct	elogpoct	PROPN
admet-529	453	2	:	:	PUNCT
admet-529	453	3	a	a	DET
admet-529	453	4	tool	tool	NOUN
admet-529	453	5	for	for	ADP
admet-529	453	6	lipophilicity	lipophilicity	NOUN
admet-529	453	7	determination	determination	NOUN
admet-529	453	8	in	in	ADP
admet-529	453	9	drug	drug	NOUN
admet-529	453	10	discovery	discovery	NOUN
admet-529	453	11	.	.	PUNCT
admet-529	454	1	journal	journal	PROPN
admet-529	454	2	of	of	ADP
admet-529	454	3	medicinal	medicinal	ADJ
admet-529	454	4	chemistry	chemistry	NOUN
admet-529	454	5	43	43	NUM
admet-529	454	6	(	(	PUNCT
admet-529	454	7	2000	2000	NUM
admet-529	454	8	)	)	PUNCT
admet-529	454	9	2922	2922	NUM
admet-529	454	10	-	-	SYM
admet-529	454	11	2928	2928	NUM
admet-529	454	12	.	.	PUNCT
admet-529	455	1	[	[	X
admet-529	455	2	56	56	NUM
admet-529	455	3	]	]	X
admet-529	455	4	y.	y.	PROPN
admet-529	455	5	gravenfors	gravenfors	PROPN
admet-529	455	6	,	,	PUNCT
admet-529	455	7	j.	j.	PROPN
admet-529	455	8	viklund	viklund	PROPN
admet-529	455	9	,	,	PUNCT
admet-529	455	10	j.	j.	PROPN
admet-529	455	11	blid	blid	PROPN
admet-529	455	12	,	,	PUNCT
admet-529	455	13	t.	t.	NOUN
admet-529	455	14	ginman	ginman	NOUN
admet-529	455	15	,	,	PUNCT
admet-529	455	16	s.	s.	PROPN
admet-529	455	17	karlström	karlström	PROPN
admet-529	455	18	,	,	PUNCT
admet-529	455	19	j.	j.	PROPN
admet-529	455	20	kihlström	kihlström	PROPN
admet-529	455	21	,	,	PUNCT
admet-529	455	22	k.	k.	PROPN
admet-529	455	23	kolmodin	kolmodin	PROPN
admet-529	455	24	,	,	PUNCT
admet-529	455	25	j.	j.	PROPN
admet-529	455	26	lindström	lindström	PROPN
admet-529	455	27	,	,	PUNCT
admet-529	455	28	s.	s.	PROPN
admet-529	455	29	von	von	PROPN
admet-529	455	30	berg	berg	PROPN
admet-529	455	31	,	,	PUNCT
admet-529	455	32	f.	f.	PROPN
admet-529	455	33	von	von	PROPN
admet-529	455	34	kieseritzky	kieseritzky	PROPN
admet-529	455	35	,	,	PUNCT
admet-529	455	36	c.	c.	PROPN
admet-529	455	37	slivo	slivo	PROPN
admet-529	455	38	,	,	PUNCT
admet-529	455	39	b.-m	b.-m	PROPN
admet-529	455	40	.	.	PUNCT
admet-529	456	1	swahn	swahn	NOUN
admet-529	456	2	,	,	PUNCT
admet-529	456	3	l.-l	l.-l	PROPN
admet-529	456	4	.	.	PUNCT
admet-529	457	1	olsson	olsson	PROPN
admet-529	457	2	,	,	PUNCT
admet-529	457	3	p.	p.	PROPN
admet-529	457	4	johansson	johansson	PROPN
admet-529	457	5	,	,	PUNCT
admet-529	457	6	s.	s.	PROPN
admet-529	457	7	eketjäll	eketjäll	PROPN
admet-529	457	8	,	,	PUNCT
admet-529	457	9	j.	j.	PROPN
admet-529	457	10	fälting	fälting	PROPN
admet-529	457	11	,	,	PUNCT
admet-529	457	12	f.	f.	PROPN
admet-529	457	13	jeppsson	jeppsson	PROPN
admet-529	457	14	,	,	PUNCT
admet-529	457	15	k.	k.	PROPN
admet-529	457	16	strömberg	strömberg	PROPN
admet-529	457	17	,	,	PUNCT
admet-529	457	18	j.	j.	PROPN
admet-529	457	19	janson	janson	PROPN
admet-529	457	20	,	,	PUNCT
admet-529	457	21	f.	f.	PROPN
admet-529	457	22	rahm	rahm	PROPN
admet-529	457	23	.	.	PUNCT
admet-529	458	1	new	new	ADJ
admet-529	458	2	aminoimidazoles	aminoimidazole	NOUN
admet-529	458	3	as	as	ADP
admet-529	458	4	β	β	NOUN
admet-529	458	5	-	-	NOUN
admet-529	458	6	secretase	secretase	NOUN
admet-529	458	7	(	(	PUNCT
admet-529	458	8	bace-1	bace-1	PROPN
admet-529	458	9	)	)	PUNCT
admet-529	458	10	inhibitors	inhibitor	NOUN
admet-529	458	11	showing	show	VERB
admet-529	458	12	amyloid	amyloid	NOUN
admet-529	458	13	-	-	PUNCT
admet-529	458	14	β	β	X
admet-529	458	15	(	(	PUNCT
admet-529	458	16	aβ	aβ	NOUN
admet-529	458	17	)	)	PUNCT
admet-529	458	18	lowering	lower	VERB
admet-529	458	19	in	in	ADP
admet-529	458	20	brain	brain	NOUN
admet-529	458	21	.	.	PUNCT
admet-529	459	1	journal	journal	PROPN
admet-529	459	2	of	of	ADP
admet-529	459	3	medicinal	medicinal	ADJ
admet-529	459	4	chemistry	chemistry	NOUN
admet-529	459	5	55	55	NUM
admet-529	459	6	(	(	PUNCT
admet-529	459	7	2012	2012	NUM
admet-529	459	8	)	)	PUNCT
admet-529	459	9	9297	9297	NUM
admet-529	459	10	-	-	SYM
admet-529	459	11	9311	9311	NUM
admet-529	459	12	.	.	PUNCT
admet-529	460	1	[	[	X
admet-529	460	2	57	57	NUM
admet-529	460	3	]	]	PUNCT
admet-529	460	4	p.	p.	NOUN
admet-529	460	5	mukherjee	mukherjee	PROPN
admet-529	460	6	,	,	PUNCT
admet-529	460	7	m.	m.	NOUN
admet-529	460	8	pettersson	pettersson	PROPN
admet-529	460	9	,	,	PUNCT
admet-529	460	10	j.k	j.k	PROPN
admet-529	460	11	.	.	PROPN
admet-529	460	12	dutra	dutra	PROPN
admet-529	460	13	,	,	PUNCT
admet-529	460	14	l.	l.	PROPN
admet-529	460	15	xie	xie	PROPN
admet-529	460	16	,	,	PUNCT
admet-529	460	17	c.w	c.w	PROPN
admet-529	460	18	.	.	PROPN
admet-529	460	19	am	be	AUX
admet-529	460	20	ende	ende	ADJ
admet-529	460	21	.	.	PUNCT
admet-529	461	1	trifluoromethyl	trifluoromethyl	PROPN
admet-529	461	2	oxetanes	oxetane	NOUN
admet-529	461	3	:	:	PUNCT
admet-529	461	4	synthesis	synthesis	NOUN
admet-529	461	5	and	and	CCONJ
admet-529	461	6	evaluation	evaluation	NOUN
admet-529	461	7	as	as	ADP
admet-529	461	8	a	a	DET
admet-529	461	9	tert	tert	NOUN
admet-529	461	10	-	-	PUNCT
admet-529	461	11	butyl	butyl	NOUN
admet-529	461	12	isostere	isostere	NOUN
admet-529	461	13	.	.	PUNCT
admet-529	462	1	chemmedchem	chemmedchem	PROPN
admet-529	462	2	12	12	NUM
admet-529	462	3	(	(	PUNCT
admet-529	462	4	2017	2017	NUM
admet-529	462	5	)	)	PUNCT
admet-529	462	6	1574	1574	NUM
admet-529	462	7	-	-	SYM
admet-529	462	8	1577	1577	NUM
admet-529	462	9	.	.	PUNCT
admet-529	463	1	[	[	X
admet-529	463	2	58	58	NUM
admet-529	463	3	]	]	X
admet-529	463	4	a.f	a.f	PROPN
admet-529	463	5	.	.	PROPN
admet-529	463	6	stepan	stepan	PROPN
admet-529	463	7	,	,	PUNCT
admet-529	463	8	k.	k.	PROPN
admet-529	463	9	karki	karki	PROPN
admet-529	463	10	,	,	PUNCT
admet-529	463	11	w.s	w.s	PROPN
admet-529	463	12	.	.	PROPN
admet-529	463	13	mcdonald	mcdonald	PROPN
admet-529	463	14	,	,	PUNCT
admet-529	463	15	p.h	p.h	PROPN
admet-529	463	16	.	.	PROPN
admet-529	463	17	dorff	dorff	PROPN
admet-529	463	18	,	,	PUNCT
admet-529	463	19	j.k	j.k	PROPN
admet-529	463	20	.	.	PROPN
admet-529	463	21	dutra	dutra	PROPN
admet-529	463	22	,	,	PUNCT
admet-529	463	23	k.j	k.j	PROPN
admet-529	463	24	.	.	PROPN
admet-529	463	25	dirico	dirico	PROPN
admet-529	463	26	,	,	PUNCT
admet-529	463	27	a.	a.	NOUN
admet-529	463	28	won	won	PROPN
admet-529	463	29	,	,	PUNCT
admet-529	463	30	c.	c.	PROPN
admet-529	463	31	subramanyam	subramanyam	PROPN
admet-529	463	32	,	,	PUNCT
admet-529	463	33	i.v	i.v	PROPN
admet-529	463	34	.	.	PROPN
admet-529	463	35	efremov	efremov	PROPN
admet-529	463	36	,	,	PUNCT
admet-529	463	37	c.j	c.j	PROPN
admet-529	463	38	.	.	PROPN
admet-529	463	39	o'donnell	o'donnell	PROPN
admet-529	463	40	,	,	PUNCT
admet-529	463	41	c.e	c.e	PROPN
admet-529	463	42	.	.	PROPN
admet-529	463	43	nolan	nolan	PROPN
admet-529	463	44	,	,	PUNCT
admet-529	463	45	s.l	s.l	PROPN
admet-529	463	46	.	.	PROPN
admet-529	463	47	becker	becker	PROPN
admet-529	463	48	,	,	PUNCT
admet-529	463	49	l.r	l.r	PROPN
admet-529	463	50	.	.	PROPN
admet-529	463	51	pustilnik	pustilnik	PROPN
admet-529	463	52	,	,	PUNCT
admet-529	463	53	b.	b.	PROPN
admet-529	463	54	sneed	sneed	PROPN
admet-529	463	55	,	,	PUNCT
admet-529	463	56	h.	h.	PROPN
admet-529	463	57	sun	sun	PROPN
admet-529	463	58	,	,	PUNCT
admet-529	463	59	y.	y.	PROPN
admet-529	463	60	lu	lu	PROPN
admet-529	463	61	,	,	PUNCT
admet-529	463	62	a.e	a.e	PROPN
admet-529	463	63	.	.	PROPN
admet-529	463	64	robshaw	robshaw	PROPN
admet-529	463	65	,	,	PUNCT
admet-529	463	66	d.	d.	PROPN
admet-529	463	67	riddell	riddell	PROPN
admet-529	463	68	,	,	PUNCT
admet-529	463	69	t.j	t.j	PROPN
admet-529	463	70	.	.	PROPN
admet-529	463	71	o'sullivan	o'sullivan	PROPN
admet-529	463	72	,	,	PUNCT
admet-529	463	73	e.	e.	PROPN
admet-529	463	74	sibley	sibley	PROPN
admet-529	463	75	,	,	PUNCT
admet-529	463	76	s.	s.	PROPN
admet-529	463	77	capetta	capetta	PROPN
admet-529	463	78	,	,	PUNCT
admet-529	463	79	k.	k.	PROPN
admet-529	463	80	atchison	atchison	PROPN
admet-529	463	81	,	,	PUNCT
admet-529	463	82	a.j	a.j	PROPN
admet-529	463	83	.	.	PROPN
admet-529	463	84	hallgren	hallgren	PROPN
admet-529	463	85	,	,	PUNCT
admet-529	463	86	e.	e.	PROPN
admet-529	463	87	miller	miller	PROPN
admet-529	463	88	,	,	PUNCT
admet-529	463	89	a.	a.	NOUN
admet-529	463	90	wood	wood	PROPN
admet-529	463	91	,	,	PUNCT
admet-529	463	92	r.s	r.s	PROPN
admet-529	463	93	.	.	PROPN
admet-529	463	94	obach	obach	PROPN
admet-529	463	95	.	.	PUNCT
admet-529	464	1	metabolism	metabolism	NOUN
admet-529	464	2	-	-	PUNCT
admet-529	464	3	directed	direct	VERB
admet-529	464	4	design	design	NOUN
admet-529	464	5	of	of	ADP
admet-529	464	6	oxetane	oxetane	NOUN
admet-529	464	7	-	-	PUNCT
admet-529	464	8	containing	contain	VERB
admet-529	464	9	arylsulfonamide	arylsulfonamide	NOUN
admet-529	464	10	derivatives	derivative	NOUN
admet-529	464	11	as	as	ADP
admet-529	464	12	gamma	gamma	NOUN
admet-529	464	13	-	-	PUNCT
admet-529	464	14	secretase	secretase	NOUN
admet-529	464	15	inhibitors	inhibitor	NOUN
admet-529	464	16	.	.	PUNCT
admet-529	465	1	j	j	PROPN
admet-529	465	2	med	med	PROPN
admet-529	465	3	chem	chem	NOUN
admet-529	465	4	54	54	NUM
admet-529	465	5	(	(	PUNCT
admet-529	465	6	2011	2011	NUM
admet-529	465	7	)	)	PUNCT
admet-529	465	8	7772	7772	NUM
admet-529	465	9	-	-	SYM
admet-529	465	10	7783	7783	NUM
admet-529	465	11	.	.	PUNCT
admet-529	466	1	[	[	X
admet-529	466	2	59	59	NUM
admet-529	466	3	]	]	SYM
admet-529	466	4	d.a	d.a	PROPN
admet-529	466	5	.	.	PROPN
admet-529	466	6	griffith	griffith	PROPN
admet-529	466	7	,	,	PUNCT
admet-529	466	8	r.l	r.l	PROPN
admet-529	466	9	.	.	PROPN
admet-529	466	10	dow	dow	PROPN
admet-529	466	11	,	,	PUNCT
admet-529	466	12	k.	k.	PROPN
admet-529	466	13	huard	huard	PROPN
admet-529	466	14	,	,	PUNCT
admet-529	466	15	d.j	d.j	PROPN
admet-529	466	16	.	.	PROPN
admet-529	466	17	edmonds	edmonds	PROPN
admet-529	466	18	,	,	PUNCT
admet-529	466	19	s.w	s.w	PROPN
admet-529	466	20	.	.	PROPN
admet-529	466	21	bagley	bagley	PROPN
admet-529	466	22	,	,	PUNCT
admet-529	466	23	j.	j.	PROPN
admet-529	466	24	polivkova	polivkova	PROPN
admet-529	466	25	,	,	PUNCT
admet-529	466	26	d.	d.	PROPN
admet-529	466	27	zeng	zeng	PROPN
admet-529	466	28	,	,	PUNCT
admet-529	466	29	c.n	c.n	PROPN
admet-529	466	30	.	.	PROPN
admet-529	466	31	garciairizarry	garciairizarry	PROPN
admet-529	466	32	,	,	PUNCT
admet-529	466	33	j.a	j.a	PROPN
admet-529	466	34	.	.	PROPN
admet-529	466	35	southers	souther	NOUN
admet-529	466	36	,	,	PUNCT
admet-529	466	37	w.	w.	NOUN
admet-529	466	38	esler	esler	NOUN
admet-529	466	39	,	,	PUNCT
admet-529	466	40	p.	p.	PROPN
admet-529	466	41	amor	amor	PROPN
admet-529	466	42	,	,	PUNCT
admet-529	466	43	k.	k.	PROPN
admet-529	466	44	loomis	loomis	PROPN
admet-529	466	45	,	,	PUNCT
admet-529	466	46	k.	k.	PROPN
admet-529	466	47	mcpherson	mcpherson	PROPN
admet-529	466	48	,	,	PUNCT
admet-529	466	49	k.b	k.b	PROPN
admet-529	466	50	.	.	PROPN
admet-529	466	51	bahnck	bahnck	PROPN
admet-529	466	52	,	,	PUNCT
admet-529	466	53	c.	c.	PROPN
admet-529	466	54	preville	preville	PROPN
admet-529	466	55	,	,	PUNCT
admet-529	466	56	t.	t.	PROPN
admet-529	466	57	banks	banks	PROPN
admet-529	466	58	,	,	PUNCT
admet-529	466	59	d.e	d.e	PROPN
admet-529	466	60	.	.	PROPN
admet-529	466	61	moore	moore	PROPN
admet-529	466	62	,	,	PUNCT
admet-529	466	63	a.m.	a.m.	PROPN
admet-529	466	64	mathiowetz	mathiowetz	PROPN
admet-529	466	65	,	,	PUNCT
admet-529	466	66	e.	e.	PROPN
admet-529	466	67	menhaji	menhaji	PROPN
admet-529	466	68	-	-	PUNCT
admet-529	466	69	klotz	klotz	PROPN
admet-529	466	70	,	,	PUNCT
admet-529	466	71	a.c	a.c	PROPN
admet-529	466	72	.	.	PROPN
admet-529	466	73	smith	smith	PROPN
admet-529	466	74	,	,	PUNCT
admet-529	466	75	s.d	s.d	PROPN
admet-529	466	76	.	.	PROPN
admet-529	466	77	doran	doran	PROPN
admet-529	466	78	,	,	PUNCT
admet-529	466	79	d.a	d.a	PROPN
admet-529	466	80	.	.	PROPN
admet-529	466	81	beebe	beebe	PROPN
admet-529	466	82	,	,	PUNCT
admet-529	466	83	m.f	m.f	PROPN
admet-529	466	84	.	.	PUNCT
admet-529	467	1	dunn	dunn	PROPN
admet-529	467	2	.	.	PUNCT
admet-529	467	3	spirolactam	spirolactam	PROPN
admet-529	467	4	-	-	PUNCT
admet-529	467	5	based	base	VERB
admet-529	467	6	acetyl	acetyl	NOUN
admet-529	467	7	-	-	PUNCT
admet-529	467	8	coa	coa	NOUN
admet-529	467	9	carboxylase	carboxylase	NOUN
admet-529	467	10	inhibitors	inhibitor	NOUN
admet-529	467	11	:	:	PUNCT
admet-529	467	12	toward	toward	ADP
admet-529	467	13	improved	improve	VERB
admet-529	467	14	metabolic	metabolic	NOUN
admet-529	467	15	stability	stability	NOUN
admet-529	467	16	of	of	ADP
admet-529	467	17	a	a	DET
admet-529	467	18	chromanone	chromanone	NOUN
admet-529	467	19	lead	lead	NOUN
admet-529	467	20	structure	structure	NOUN
admet-529	467	21	.	.	PUNCT
admet-529	468	1	j	j	PROPN
admet-529	468	2	med	med	PROPN
admet-529	468	3	chem	chem	NOUN
admet-529	468	4	56	56	NUM
admet-529	468	5	(	(	PUNCT
admet-529	468	6	2013	2013	NUM
admet-529	468	7	)	)	PUNCT
admet-529	468	8	7110	7110	NUM
admet-529	468	9	-	-	SYM
admet-529	468	10	7119	7119	NUM
admet-529	468	11	.	.	PUNCT
admet-529	469	1	[	[	X
admet-529	469	2	60	60	NUM
admet-529	469	3	]	]	X
admet-529	469	4	j.e	j.e	PROPN
admet-529	469	5	.	.	PROPN
admet-529	469	6	davoren	davoren	PROPN
admet-529	469	7	,	,	PUNCT
admet-529	469	8	c.w	c.w	PROPN
admet-529	469	9	.	.	PROPN
admet-529	469	10	lee	lee	PROPN
admet-529	469	11	,	,	PUNCT
admet-529	469	12	m.	m.	PROPN
admet-529	469	13	garnsey	garnsey	PROPN
admet-529	469	14	,	,	PUNCT
admet-529	469	15	m.a	m.a	PROPN
admet-529	469	16	.	.	PROPN
admet-529	469	17	brodney	brodney	PROPN
admet-529	469	18	,	,	PUNCT
admet-529	469	19	j.	j.	PROPN
admet-529	469	20	cordes	cordes	PROPN
admet-529	469	21	,	,	PUNCT
admet-529	469	22	k.	k.	PROPN
admet-529	469	23	dlugolenski	dlugolenski	PROPN
admet-529	469	24	,	,	PUNCT
admet-529	469	25	j.r	j.r	PROPN
admet-529	469	26	.	.	PROPN
admet-529	469	27	edgerton	edgerton	PROPN
admet-529	469	28	,	,	PUNCT
admet-529	469	29	a.r	a.r	PROPN
admet-529	469	30	.	.	PROPN
admet-529	469	31	harris	harris	PROPN
admet-529	469	32	,	,	PUNCT
admet-529	469	33	c.j	c.j	PROPN
admet-529	469	34	.	.	PROPN
admet-529	469	35	helal	helal	PROPN
admet-529	469	36	,	,	PUNCT
admet-529	469	37	s.	s.	PROPN
admet-529	469	38	jenkinson	jenkinson	PROPN
admet-529	469	39	,	,	PUNCT
admet-529	469	40	g.w	g.w	PROPN
admet-529	469	41	.	.	PROPN
admet-529	469	42	kauffman	kauffman	PROPN
admet-529	469	43	,	,	PUNCT
admet-529	469	44	t.p	t.p	PROPN
admet-529	469	45	.	.	PROPN
admet-529	469	46	kenakin	kenakin	PROPN
admet-529	469	47	,	,	PUNCT
admet-529	469	48	j.t	j.t	PROPN
admet-529	469	49	.	.	PROPN
admet-529	469	50	lazzaro	lazzaro	PROPN
admet-529	469	51	,	,	PUNCT
admet-529	469	52	s.m	s.m	PROPN
admet-529	469	53	.	.	PROPN
admet-529	469	54	lotarski	lotarski	PROPN
admet-529	469	55	,	,	PUNCT
admet-529	469	56	y.	y.	PROPN
admet-529	469	57	mao	mao	PROPN
admet-529	469	58	,	,	PUNCT
admet-529	469	59	d.m	d.m	PROPN
admet-529	469	60	.	.	PUNCT
admet-529	469	61	nason	nason	PROPN
admet-529	469	62	,	,	PUNCT
admet-529	469	63	c.	c.	PROPN
admet-529	469	64	northcott	northcott	PROPN
admet-529	469	65	,	,	PUNCT
admet-529	469	66	l.	l.	PROPN
admet-529	469	67	nottebaum	nottebaum	PROPN
admet-529	469	68	,	,	PUNCT
admet-529	469	69	s.v	s.v	PROPN
admet-529	469	70	.	.	PROPN
admet-529	469	71	o'neil	o'neil	PROPN
admet-529	469	72	,	,	PUNCT
admet-529	469	73	b.	b.	PROPN
admet-529	469	74	pettersen	pettersen	PROPN
admet-529	469	75	,	,	PUNCT
admet-529	469	76	m.	m.	NOUN
admet-529	469	77	popiolek	popiolek	NOUN
admet-529	469	78	,	,	PUNCT
admet-529	469	79	v.	v.	PROPN
admet-529	469	80	reinhart	reinhart	PROPN
admet-529	469	81	,	,	PUNCT
admet-529	469	82	r.	r.	PROPN
admet-529	469	83	salomon	salomon	PROPN
admet-529	469	84	-	-	PUNCT
admet-529	469	85	ferrer	ferrer	PROPN
admet-529	469	86	,	,	PUNCT
admet-529	469	87	s.j	s.j	PROPN
admet-529	469	88	.	.	PROPN
admet-529	469	89	steyn	steyn	PROPN
admet-529	469	90	,	,	PUNCT
admet-529	469	91	d.	d.	PROPN
admet-529	469	92	webb	webb	PROPN
admet-529	469	93	,	,	PUNCT
admet-529	469	94	l.	l.	PROPN
admet-529	469	95	zhang	zhang	PROPN
admet-529	469	96	,	,	PUNCT
admet-529	469	97	s.	s.	PROPN
admet-529	469	98	grimwood	grimwood	PROPN
admet-529	469	99	.	.	PUNCT
admet-529	470	1	discovery	discovery	NOUN
admet-529	470	2	of	of	ADP
admet-529	470	3	the	the	DET
admet-529	470	4	potent	potent	ADJ
admet-529	470	5	and	and	CCONJ
admet-529	470	6	selective	selective	ADJ
admet-529	470	7	m1	m1	PROPN
admet-529	470	8	pam	pam	NOUN
admet-529	470	9	-	-	PUNCT
admet-529	470	10	agonist	agonist	NOUN
admet-529	470	11	n-[(3r,4s)-3	n-[(3r,4s)-3	PROPN
admet-529	470	12	-	-	PUNCT
admet-529	470	13	hydroxytetrahydro-2h	hydroxytetrahydro-2h	NOUN
admet-529	470	14	-	-	PUNCT
admet-529	470	15	pyran-4	pyran-4	NOUN
admet-529	470	16	-	-	PUNCT
admet-529	470	17	yl]-5	yl]-5	NOUN
admet-529	470	18	-	-	PUNCT
admet-529	470	19	methyl-4-[4-(1,3	methyl-4-[4-(1,3	NOUN
admet-529	470	20	-	-	PUNCT
admet-529	470	21	thiazol-4yl)ben	thiazol-4yl)ben	NOUN
admet-529	470	22	zyl]pyridine-2	zyl]pyridine-2	NOUN
admet-529	470	23	-	-	PUNCT
admet-529	470	24	carboxamide	carboxamide	NOUN
admet-529	470	25	(	(	PUNCT
admet-529	470	26	pf-06767832	pf-06767832	NOUN
admet-529	470	27	):	):	PUNCT
admet-529	470	28	evaluation	evaluation	NOUN
admet-529	470	29	of	of	ADP
admet-529	470	30	efficacy	efficacy	NOUN
admet-529	470	31	and	and	CCONJ
admet-529	470	32	cholinergic	cholinergic	ADJ
admet-529	470	33	side	side	NOUN
admet-529	470	34	effects	effect	NOUN
admet-529	470	35	.	.	PUNCT
admet-529	471	1	j	j	PROPN
admet-529	471	2	med	med	PROPN
admet-529	471	3	chem	chem	NOUN
admet-529	471	4	59	59	NUM
admet-529	471	5	(	(	PUNCT
admet-529	471	6	2016	2016	NUM
admet-529	471	7	)	)	PUNCT
admet-529	471	8	6313	6313	NUM
admet-529	471	9	-	-	SYM
admet-529	471	10	6328	6328	NUM
admet-529	471	11	.	.	PUNCT
admet-529	472	1	[	[	X
admet-529	472	2	61	61	NUM
admet-529	472	3	]	]	PUNCT
admet-529	472	4	a.	a.	NOUN
admet-529	472	5	forsberg	forsberg	PROPN
admet-529	472	6	,	,	PUNCT
admet-529	472	7	a.	a.	NOUN
admet-529	472	8	juréus	juréus	NOUN
admet-529	472	9	,	,	PUNCT
admet-529	472	10	z.	z.	PROPN
admet-529	472	11	cselényi	cselényi	PROPN
admet-529	472	12	,	,	PUNCT
admet-529	472	13	m.	m.	NOUN
admet-529	472	14	eriksdotter	eriksdotter	PROPN
admet-529	472	15	,	,	PUNCT
admet-529	472	16	y.	y.	PROPN
admet-529	472	17	freund	freund	PROPN
admet-529	472	18	-	-	PUNCT
admet-529	472	19	levi	levi	PROPN
admet-529	472	20	,	,	PUNCT
admet-529	472	21	f.	f.	PROPN
admet-529	472	22	jeppsson	jeppsson	PROPN
admet-529	472	23	,	,	PUNCT
admet-529	472	24	b.-m	b.-m	PROPN
admet-529	472	25	.	.	PUNCT
admet-529	473	1	swahn	swahn	PROPN
admet-529	473	2	,	,	PUNCT
admet-529	473	3	j.	j.	PROPN
admet-529	473	4	sandell	sandell	PROPN
admet-529	473	5	,	,	PUNCT
admet-529	473	6	p.	p.	PROPN
admet-529	473	7	julin	julin	PROPN
admet-529	473	8	,	,	PUNCT
admet-529	473	9	m.	m.	NOUN
admet-529	473	10	schou	schou	PROPN
admet-529	473	11	,	,	PUNCT
admet-529	473	12	j.	j.	PROPN
admet-529	473	13	andersson	andersson	PROPN
admet-529	473	14	,	,	PUNCT
admet-529	473	15	p.	p.	PROPN
admet-529	473	16	johnström	johnström	NOUN
admet-529	473	17	,	,	PUNCT
admet-529	473	18	k.	k.	PROPN
admet-529	473	19	varnäs	varnäs	PROPN
admet-529	473	20	,	,	PUNCT
admet-529	473	21	c.	c.	PROPN
admet-529	473	22	halldin	halldin	PROPN
admet-529	473	23	,	,	PUNCT
admet-529	473	24	l.	l.	PROPN
admet-529	473	25	farde	farde	PROPN
admet-529	473	26	,	,	PUNCT
admet-529	473	27	s.	s.	PROPN
admet-529	473	28	svensson	svensson	PROPN
admet-529	473	29	.	.	PUNCT
admet-529	474	1	low	low	ADJ
admet-529	474	2	background	background	NOUN
admet-529	474	3	and	and	CCONJ
admet-529	474	4	high	high	ADJ
admet-529	474	5	contrast	contrast	NOUN
admet-529	474	6	pet	pet	ADJ
admet-529	474	7	imaging	imaging	NOUN
admet-529	474	8	of	of	ADP
admet-529	474	9	amyloid	amyloid	NOUN
admet-529	474	10	-	-	PUNCT
admet-529	474	11	β	β	NOUN
admet-529	474	12	with	with	ADP
admet-529	474	13	[	[	X
admet-529	474	14	(	(	PUNCT
admet-529	474	15	11)c]azd2995	11)c]azd2995	NOUN
admet-529	474	16	and	and	CCONJ
admet-529	474	17	g.h	g.h	PROPN
admet-529	474	18	.	.	PROPN
admet-529	474	19	goetz	goetz	PROPN
admet-529	474	20	and	and	CCONJ
admet-529	474	21	m.	m.	NOUN
admet-529	474	22	shalaeva	shalaeva	PROPN
admet-529	474	23	admet	admet	PROPN
admet-529	474	24	&	&	CCONJ
admet-529	474	25	dmpk	dmpk	PROPN
admet-529	474	26	6(2	6(2	NUM
admet-529	474	27	)	)	PUNCT
admet-529	474	28	(	(	PUNCT
admet-529	474	29	2018	2018	NUM
admet-529	474	30	)	)	PUNCT
admet-529	474	31	85	85	NUM
admet-529	474	32	-	-	SYM
admet-529	474	33	104	104	NUM
admet-529	474	34	102	102	NUM
admet-529	474	35	[	[	X
admet-529	474	36	(	(	PUNCT
admet-529	474	37	11)c]azd2184	11)c]azd2184	NOUN
admet-529	474	38	in	in	ADP
admet-529	474	39	alzheimer	alzheimer	PROPN
admet-529	474	40	’s	’s	PART
admet-529	474	41	disease	disease	NOUN
admet-529	474	42	patients	patient	NOUN
admet-529	474	43	.	.	PUNCT
admet-529	475	1	european	european	ADJ
admet-529	475	2	journal	journal	PROPN
admet-529	475	3	of	of	ADP
admet-529	475	4	nuclear	nuclear	ADJ
admet-529	475	5	medicine	medicine	NOUN
admet-529	475	6	and	and	CCONJ
admet-529	475	7	molecular	molecular	ADJ
admet-529	475	8	imaging	imaging	NOUN
admet-529	475	9	40	40	NUM
admet-529	475	10	(	(	PUNCT
admet-529	475	11	2013	2013	NUM
admet-529	475	12	)	)	PUNCT
admet-529	475	13	580	580	NUM
admet-529	475	14	-	-	SYM
admet-529	475	15	593	593	NUM
admet-529	475	16	.	.	PUNCT
admet-529	476	1	[	[	X
admet-529	476	2	62	62	NUM
admet-529	476	3	]	]	PUNCT
admet-529	476	4	k.	k.	PROPN
admet-529	476	5	palm	palm	PROPN
admet-529	476	6	,	,	PUNCT
admet-529	476	7	k.	k.	PROPN
admet-529	476	8	luthman	luthman	PROPN
admet-529	476	9	,	,	PUNCT
admet-529	476	10	a.l	a.l	PROPN
admet-529	476	11	.	.	NOUN
admet-529	476	12	ungell	ungell	PROPN
admet-529	476	13	,	,	PUNCT
admet-529	476	14	g.	g.	PROPN
admet-529	476	15	strandlund	strandlund	PROPN
admet-529	476	16	,	,	PUNCT
admet-529	476	17	p.	p.	PROPN
admet-529	476	18	artursson	artursson	PROPN
admet-529	476	19	.	.	PUNCT
admet-529	477	1	correlation	correlation	NOUN
admet-529	477	2	of	of	ADP
admet-529	477	3	drug	drug	NOUN
admet-529	477	4	absorption	absorption	NOUN
admet-529	477	5	with	with	ADP
admet-529	477	6	molecular	molecular	ADJ
admet-529	477	7	surface	surface	NOUN
admet-529	477	8	properties	property	NOUN
admet-529	477	9	.	.	PUNCT
admet-529	478	1	j	j	PROPN
admet-529	478	2	pharm	pharm	PROPN
admet-529	478	3	sci	sci	PROPN
admet-529	478	4	85	85	NUM
admet-529	478	5	(	(	PUNCT
admet-529	478	6	1996	1996	NUM
admet-529	478	7	)	)	PUNCT
admet-529	478	8	32	32	NUM
admet-529	478	9	-	-	SYM
admet-529	478	10	39	39	NUM
admet-529	478	11	.	.	PUNCT
admet-529	479	1	[	[	X
admet-529	479	2	63	63	NUM
admet-529	479	3	]	]	PUNCT
admet-529	479	4	h.	h.	PROPN
admet-529	479	5	van	van	PROPN
admet-529	479	6	de	de	PROPN
admet-529	479	7	waterbeemd	waterbeemd	PROPN
admet-529	479	8	,	,	PUNCT
admet-529	479	9	g.	g.	PROPN
admet-529	479	10	camenisch	camenisch	PROPN
admet-529	479	11	,	,	PUNCT
admet-529	479	12	g.	g.	PROPN
admet-529	479	13	folkers	folkers	PROPN
admet-529	479	14	,	,	PUNCT
admet-529	479	15	o.a	o.a	PROPN
admet-529	479	16	.	.	PROPN
admet-529	479	17	raevsky	raevsky	PROPN
admet-529	479	18	.	.	PUNCT
admet-529	480	1	estimation	estimation	NOUN
admet-529	480	2	of	of	ADP
admet-529	480	3	caco-2	caco-2	NUM
admet-529	480	4	cell	cell	NOUN
admet-529	480	5	permeability	permeability	NOUN
admet-529	480	6	using	use	VERB
admet-529	480	7	calculated	calculate	VERB
admet-529	480	8	molecular	molecular	ADJ
admet-529	480	9	descriptors	descriptor	NOUN
admet-529	480	10	.	.	PUNCT
admet-529	481	1	quantitative	quantitative	ADJ
admet-529	481	2	structure	structure	NOUN
admet-529	481	3	-	-	PUNCT
admet-529	481	4	activity	activity	NOUN
admet-529	481	5	relationships	relationship	NOUN
admet-529	481	6	15	15	NUM
admet-529	481	7	(	(	PUNCT
admet-529	481	8	1996	1996	NUM
admet-529	481	9	)	)	PUNCT
admet-529	481	10	480	480	NUM
admet-529	481	11	-	-	SYM
admet-529	481	12	490	490	NUM
admet-529	481	13	.	.	PUNCT
admet-529	482	1	[	[	X
admet-529	482	2	64	64	NUM
admet-529	482	3	]	]	X
admet-529	482	4	y.h	y.h	PROPN
admet-529	482	5	.	.	PROPN
admet-529	482	6	zhao	zhao	PROPN
admet-529	482	7	,	,	PUNCT
admet-529	482	8	m.h	m.h	PROPN
admet-529	482	9	.	.	PROPN
admet-529	482	10	abraham	abraham	PROPN
admet-529	482	11	,	,	PUNCT
admet-529	482	12	a.	a.	PROPN
admet-529	482	13	ibrahim	ibrahim	PROPN
admet-529	482	14	,	,	PUNCT
admet-529	482	15	p.v	p.v	PROPN
admet-529	482	16	.	.	PROPN
admet-529	482	17	fish	fish	PROPN
admet-529	482	18	,	,	PUNCT
admet-529	482	19	s.	s.	PROPN
admet-529	482	20	cole	cole	PROPN
admet-529	482	21	,	,	PUNCT
admet-529	482	22	m.l	m.l	PROPN
admet-529	482	23	.	.	PROPN
admet-529	482	24	lewis	lewis	PROPN
admet-529	482	25	,	,	PUNCT
admet-529	482	26	m.j	m.j	PROPN
admet-529	482	27	.	.	PROPN
admet-529	482	28	de	de	PROPN
admet-529	482	29	groot	groot	PROPN
admet-529	482	30	,	,	PUNCT
admet-529	482	31	d.p	d.p	PROPN
admet-529	482	32	.	.	PROPN
admet-529	482	33	reynolds	reynolds	PROPN
admet-529	482	34	.	.	PUNCT
admet-529	482	35	predicting	predict	VERB
admet-529	482	36	penetration	penetration	NOUN
admet-529	482	37	across	across	ADP
admet-529	482	38	the	the	DET
admet-529	482	39	blood	blood	NOUN
admet-529	482	40	-	-	PUNCT
admet-529	482	41	brain	brain	NOUN
admet-529	482	42	barrier	barrier	NOUN
admet-529	482	43	from	from	ADP
admet-529	482	44	simple	simple	ADJ
admet-529	482	45	descriptors	descriptor	NOUN
admet-529	482	46	and	and	CCONJ
admet-529	482	47	fragmentation	fragmentation	NOUN
admet-529	482	48	schemes	scheme	NOUN
admet-529	482	49	.	.	PUNCT
admet-529	483	1	j	j	PROPN
admet-529	483	2	chem	chem	PROPN
admet-529	483	3	inf	inf	PROPN
admet-529	483	4	model	model	NOUN
admet-529	483	5	47	47	NUM
admet-529	483	6	(	(	PUNCT
admet-529	483	7	2007	2007	NUM
admet-529	483	8	)	)	PUNCT
admet-529	483	9	170	170	NUM
admet-529	483	10	-	-	SYM
admet-529	483	11	175	175	NUM
admet-529	483	12	.	.	PUNCT
admet-529	484	1	[	[	X
admet-529	484	2	65	65	NUM
admet-529	484	3	]	]	X
admet-529	484	4	k.	k.	PROPN
admet-529	484	5	palm	palm	PROPN
admet-529	484	6	,	,	PUNCT
admet-529	484	7	p.	p.	PROPN
admet-529	484	8	stenberg	stenberg	PROPN
admet-529	484	9	,	,	PUNCT
admet-529	484	10	k.	k.	PROPN
admet-529	484	11	luthman	luthman	PROPN
admet-529	484	12	,	,	PUNCT
admet-529	484	13	p.	p.	NOUN
admet-529	484	14	artursson1	artursson1	NOUN
admet-529	484	15	.	.	PUNCT
admet-529	485	1	polar	polar	ADJ
admet-529	485	2	molecular	molecular	ADJ
admet-529	485	3	surface	surface	NOUN
admet-529	485	4	properties	property	NOUN
admet-529	485	5	predict	predict	VERB
admet-529	485	6	the	the	DET
admet-529	485	7	intestinal	intestinal	ADJ
admet-529	485	8	absorption	absorption	NOUN
admet-529	485	9	of	of	ADP
admet-529	485	10	drugs	drug	NOUN
admet-529	485	11	in	in	ADP
admet-529	485	12	humans	human	NOUN
admet-529	485	13	.	.	PUNCT
admet-529	486	1	pharm	pharm	NOUN
admet-529	486	2	res	re	NOUN
admet-529	486	3	14	14	NUM
admet-529	486	4	(	(	PUNCT
admet-529	486	5	1997	1997	NUM
admet-529	486	6	)	)	PUNCT
admet-529	486	7	568	568	NUM
admet-529	486	8	-	-	SYM
admet-529	486	9	571	571	NUM
admet-529	486	10	.	.	PUNCT
admet-529	487	1	[	[	X
admet-529	487	2	66	66	NUM
admet-529	487	3	]	]	X
admet-529	487	4	d.e	d.e	PROPN
admet-529	487	5	.	.	PROPN
admet-529	487	6	clark	clark	PROPN
admet-529	487	7	.	.	PUNCT
admet-529	488	1	rapid	rapid	ADJ
admet-529	488	2	calculation	calculation	NOUN
admet-529	488	3	of	of	ADP
admet-529	488	4	polar	polar	ADJ
admet-529	488	5	molecular	molecular	ADJ
admet-529	488	6	surface	surface	NOUN
admet-529	488	7	area	area	NOUN
admet-529	488	8	and	and	CCONJ
admet-529	488	9	its	its	PRON
admet-529	488	10	application	application	NOUN
admet-529	488	11	to	to	ADP
admet-529	488	12	the	the	DET
admet-529	488	13	prediction	prediction	NOUN
admet-529	488	14	of	of	ADP
admet-529	488	15	transport	transport	NOUN
admet-529	488	16	phenomena	phenomenon	NOUN
admet-529	488	17	.	.	PUNCT
admet-529	489	1	1	1	X
admet-529	489	2	.	.	X
admet-529	489	3	prediction	prediction	NOUN
admet-529	489	4	of	of	ADP
admet-529	489	5	intestinal	intestinal	ADJ
admet-529	489	6	absorption	absorption	NOUN
admet-529	489	7	.	.	PUNCT
admet-529	490	1	j	j	PROPN
admet-529	490	2	pharm	pharm	PROPN
admet-529	490	3	sci	sci	PROPN
admet-529	490	4	88	88	NUM
admet-529	490	5	(	(	PUNCT
admet-529	490	6	1999	1999	NUM
admet-529	490	7	)	)	PUNCT
admet-529	490	8	807	807	NUM
admet-529	490	9	-	-	SYM
admet-529	490	10	814	814	NUM
admet-529	490	11	.	.	PUNCT
admet-529	491	1	[	[	X
admet-529	491	2	67	67	NUM
admet-529	491	3	]	]	X
admet-529	491	4	d.e	d.e	PROPN
admet-529	491	5	.	.	PROPN
admet-529	491	6	clark	clark	PROPN
admet-529	491	7	.	.	PUNCT
admet-529	492	1	rapid	rapid	ADJ
admet-529	492	2	calculation	calculation	NOUN
admet-529	492	3	of	of	ADP
admet-529	492	4	polar	polar	ADJ
admet-529	492	5	molecular	molecular	ADJ
admet-529	492	6	surface	surface	NOUN
admet-529	492	7	area	area	NOUN
admet-529	492	8	and	and	CCONJ
admet-529	492	9	its	its	PRON
admet-529	492	10	application	application	NOUN
admet-529	492	11	to	to	ADP
admet-529	492	12	the	the	DET
admet-529	492	13	prediction	prediction	NOUN
admet-529	492	14	of	of	ADP
admet-529	492	15	transport	transport	NOUN
admet-529	492	16	phenomena	phenomenon	NOUN
admet-529	492	17	.	.	PUNCT
admet-529	493	1	2	2	X
admet-529	493	2	.	.	X
admet-529	493	3	prediction	prediction	NOUN
admet-529	493	4	of	of	ADP
admet-529	493	5	blood	blood	NOUN
admet-529	493	6	-	-	PUNCT
admet-529	493	7	brain	brain	NOUN
admet-529	493	8	barrier	barrier	NOUN
admet-529	493	9	penetration	penetration	NOUN
admet-529	493	10	.	.	PUNCT
admet-529	494	1	j	j	PROPN
admet-529	494	2	pharm	pharm	PROPN
admet-529	494	3	sci	sci	PROPN
admet-529	494	4	88	88	NUM
admet-529	494	5	(	(	PUNCT
admet-529	494	6	1999	1999	NUM
admet-529	494	7	)	)	PUNCT
admet-529	494	8	815821	815821	NUM
admet-529	494	9	.	.	PUNCT
admet-529	495	1	[	[	X
admet-529	495	2	68	68	NUM
admet-529	495	3	]	]	PUNCT
admet-529	495	4	s.	s.	PROPN
admet-529	495	5	winiwarter	winiwarter	PROPN
admet-529	495	6	,	,	PUNCT
admet-529	495	7	n.m	n.m	PROPN
admet-529	495	8	.	.	PROPN
admet-529	495	9	bonham	bonham	PROPN
admet-529	495	10	,	,	PUNCT
admet-529	495	11	f.	f.	PROPN
admet-529	495	12	ax	ax	PROPN
admet-529	495	13	,	,	PUNCT
admet-529	495	14	a.	a.	PROPN
admet-529	495	15	hallberg	hallberg	PROPN
admet-529	495	16	,	,	PUNCT
admet-529	495	17	h.	h.	PROPN
admet-529	495	18	lennernas	lennernas	PROPN
admet-529	495	19	,	,	PUNCT
admet-529	495	20	a.	a.	PROPN
admet-529	495	21	karlen	karlen	PROPN
admet-529	495	22	.	.	PUNCT
admet-529	496	1	correlation	correlation	NOUN
admet-529	496	2	of	of	ADP
admet-529	496	3	human	human	ADJ
admet-529	496	4	jejunal	jejunal	ADJ
admet-529	496	5	permeability	permeability	NOUN
admet-529	496	6	(	(	PUNCT
admet-529	496	7	in	in	ADP
admet-529	496	8	vivo	vivo	NOUN
admet-529	496	9	)	)	PUNCT
admet-529	496	10	of	of	ADP
admet-529	496	11	drugs	drug	NOUN
admet-529	496	12	with	with	ADP
admet-529	496	13	experimentally	experimentally	ADV
admet-529	496	14	and	and	CCONJ
admet-529	496	15	theoretically	theoretically	ADV
admet-529	496	16	derived	derive	VERB
admet-529	496	17	parameters	parameter	NOUN
admet-529	496	18	.	.	PUNCT
admet-529	497	1	a	a	DET
admet-529	497	2	multivariate	multivariate	NOUN
admet-529	497	3	data	datum	NOUN
admet-529	497	4	analysis	analysis	NOUN
admet-529	497	5	approach	approach	NOUN
admet-529	497	6	.	.	PUNCT
admet-529	498	1	j	j	PROPN
admet-529	498	2	med	med	PROPN
admet-529	498	3	chem	chem	NOUN
admet-529	498	4	41	41	NUM
admet-529	498	5	(	(	PUNCT
admet-529	498	6	1998	1998	NUM
admet-529	498	7	)	)	PUNCT
admet-529	498	8	4939	4939	NUM
admet-529	498	9	-	-	SYM
admet-529	498	10	4949	4949	NUM
admet-529	498	11	.	.	PUNCT
admet-529	499	1	[	[	X
admet-529	499	2	69	69	NUM
admet-529	499	3	]	]	X
admet-529	499	4	j.	j.	PROPN
admet-529	499	5	kelder	kelder	PROPN
admet-529	499	6	,	,	PUNCT
admet-529	499	7	p.d	p.d	PROPN
admet-529	499	8	.	.	PROPN
admet-529	499	9	grootenhuis	grootenhuis	PROPN
admet-529	499	10	,	,	PUNCT
admet-529	499	11	d.m	d.m	PROPN
admet-529	499	12	.	.	PROPN
admet-529	499	13	bayada	bayada	PROPN
admet-529	499	14	,	,	PUNCT
admet-529	499	15	l.p	l.p	PROPN
admet-529	499	16	.	.	PROPN
admet-529	499	17	delbressine	delbressine	PROPN
admet-529	499	18	,	,	PUNCT
admet-529	499	19	j.p	j.p	PROPN
admet-529	499	20	.	.	PROPN
admet-529	499	21	ploemen	ploeman	NOUN
admet-529	499	22	.	.	PUNCT
admet-529	500	1	polar	polar	ADJ
admet-529	500	2	molecular	molecular	ADJ
admet-529	500	3	surface	surface	NOUN
admet-529	500	4	as	as	ADP
admet-529	500	5	a	a	DET
admet-529	500	6	dominating	dominating	NOUN
admet-529	500	7	determinant	determinant	ADJ
admet-529	500	8	for	for	ADP
admet-529	500	9	oral	oral	ADJ
admet-529	500	10	absorption	absorption	NOUN
admet-529	500	11	and	and	CCONJ
admet-529	500	12	brain	brain	NOUN
admet-529	500	13	penetration	penetration	NOUN
admet-529	500	14	of	of	ADP
admet-529	500	15	drugs	drug	NOUN
admet-529	500	16	.	.	PUNCT
admet-529	501	1	pharm	pharm	NOUN
admet-529	501	2	res	re	VERB
admet-529	501	3	16	16	NUM
admet-529	501	4	(	(	PUNCT
admet-529	501	5	1999	1999	NUM
admet-529	501	6	)	)	PUNCT
admet-529	501	7	1514	1514	NUM
admet-529	501	8	-	-	SYM
admet-529	501	9	1519	1519	NUM
admet-529	501	10	.	.	PUNCT
admet-529	502	1	[	[	X
admet-529	502	2	70	70	NUM
admet-529	502	3	]	]	X
admet-529	502	4	l.h	l.h	PROPN
admet-529	502	5	.	.	PROPN
admet-529	502	6	krarup	krarup	PROPN
admet-529	502	7	,	,	PUNCT
admet-529	502	8	i.t	i.t	PROPN
admet-529	502	9	.	.	PROPN
admet-529	502	10	christensen	christensen	PROPN
admet-529	502	11	,	,	PUNCT
admet-529	502	12	l.	l.	PROPN
admet-529	502	13	hovgaard	hovgaard	PROPN
admet-529	502	14	,	,	PUNCT
admet-529	502	15	s.	s.	PROPN
admet-529	502	16	frokjaer	frokjaer	PROPN
admet-529	502	17	.	.	PUNCT
admet-529	503	1	predicting	predict	VERB
admet-529	503	2	drug	drug	NOUN
admet-529	503	3	absorption	absorption	NOUN
admet-529	503	4	from	from	ADP
admet-529	503	5	molecular	molecular	ADJ
admet-529	503	6	surface	surface	NOUN
admet-529	503	7	properties	property	NOUN
admet-529	503	8	based	base	VERB
admet-529	503	9	on	on	ADP
admet-529	503	10	molecular	molecular	ADJ
admet-529	503	11	dynamics	dynamic	NOUN
admet-529	503	12	simulations	simulation	NOUN
admet-529	503	13	.	.	PUNCT
admet-529	504	1	pharm	pharm	NOUN
admet-529	504	2	res	re	VERB
admet-529	504	3	15	15	NUM
admet-529	504	4	(	(	PUNCT
admet-529	504	5	1998	1998	NUM
admet-529	504	6	)	)	PUNCT
admet-529	504	7	972	972	NUM
admet-529	504	8	-	-	SYM
admet-529	504	9	978	978	NUM
admet-529	504	10	.	.	PUNCT
admet-529	505	1	[	[	X
admet-529	505	2	71	71	NUM
admet-529	505	3	]	]	X
admet-529	505	4	p.	p.	NOUN
admet-529	505	5	ertl	ertl	PROPN
admet-529	505	6	,	,	PUNCT
admet-529	505	7	b.	b.	PROPN
admet-529	505	8	rohde	rohde	PROPN
admet-529	505	9	,	,	PUNCT
admet-529	505	10	p.	p.	NOUN
admet-529	505	11	selzer	selzer	PROPN
admet-529	505	12	.	.	PUNCT
admet-529	506	1	fast	fast	ADJ
admet-529	506	2	calculation	calculation	NOUN
admet-529	506	3	of	of	ADP
admet-529	506	4	molecular	molecular	ADJ
admet-529	506	5	polar	polar	ADJ
admet-529	506	6	surface	surface	NOUN
admet-529	506	7	area	area	NOUN
admet-529	506	8	as	as	ADP
admet-529	506	9	a	a	DET
admet-529	506	10	sum	sum	NOUN
admet-529	506	11	of	of	ADP
admet-529	506	12	fragmentbased	fragmentbase	VERB
admet-529	506	13	contributions	contribution	NOUN
admet-529	506	14	and	and	CCONJ
admet-529	506	15	its	its	PRON
admet-529	506	16	application	application	NOUN
admet-529	506	17	to	to	ADP
admet-529	506	18	the	the	DET
admet-529	506	19	prediction	prediction	NOUN
admet-529	506	20	of	of	ADP
admet-529	506	21	drug	drug	NOUN
admet-529	506	22	transport	transport	NOUN
admet-529	506	23	properties	property	NOUN
admet-529	506	24	.	.	PUNCT
admet-529	507	1	j	j	PROPN
admet-529	507	2	med	med	PROPN
admet-529	507	3	chem	chem	NOUN
admet-529	507	4	43	43	NUM
admet-529	507	5	(	(	PUNCT
admet-529	507	6	2000	2000	NUM
admet-529	507	7	)	)	PUNCT
admet-529	507	8	3714	3714	NUM
admet-529	507	9	-	-	SYM
admet-529	507	10	3717	3717	NUM
admet-529	507	11	.	.	PUNCT
admet-529	508	1	[	[	X
admet-529	508	2	72	72	NUM
admet-529	508	3	]	]	X
admet-529	508	4	p.	p.	NOUN
admet-529	508	5	ertl	ertl	PROPN
admet-529	508	6	,	,	PUNCT
admet-529	508	7	polar	polar	ADJ
admet-529	508	8	surface	surface	NOUN
admet-529	508	9	area	area	NOUN
admet-529	508	10	,	,	PUNCT
admet-529	508	11	molecular	molecular	ADJ
admet-529	508	12	drug	drug	NOUN
admet-529	508	13	properties	property	NOUN
admet-529	508	14	,	,	PUNCT
admet-529	508	15	wiley	wiley	PROPN
admet-529	508	16	-	-	PUNCT
admet-529	508	17	vch	vch	PROPN
admet-529	508	18	verlag	verlag	PROPN
admet-529	508	19	gmbh	gmbh	PROPN
admet-529	508	20	&	&	CCONJ
admet-529	508	21	co.	co.	PROPN
admet-529	508	22	kgaa2008	kgaa2008	PROPN
admet-529	508	23	,	,	PUNCT
admet-529	508	24	pp	pp	PROPN
admet-529	508	25	.	.	PUNCT
admet-529	509	1	111	111	NUM
admet-529	509	2	-	-	SYM
admet-529	509	3	126	126	NUM
admet-529	509	4	.	.	PUNCT
admet-529	510	1	[	[	X
admet-529	510	2	73	73	NUM
admet-529	510	3	]	]	X
admet-529	510	4	g.	g.	NOUN
admet-529	510	5	schaftenaar	schaftenaar	PROPN
admet-529	510	6	,	,	PUNCT
admet-529	510	7	j.	j.	PROPN
admet-529	510	8	de	de	PROPN
admet-529	510	9	vlieg	vlieg	PROPN
admet-529	510	10	.	.	PUNCT
admet-529	511	1	quantum	quantum	PROPN
admet-529	511	2	mechanical	mechanical	ADJ
admet-529	511	3	polar	polar	ADJ
admet-529	511	4	surface	surface	NOUN
admet-529	511	5	area	area	NOUN
admet-529	511	6	.	.	PUNCT
admet-529	512	1	journal	journal	PROPN
admet-529	512	2	of	of	ADP
admet-529	512	3	computer	computer	NOUN
admet-529	512	4	-	-	PUNCT
admet-529	512	5	aided	aid	VERB
admet-529	512	6	molecular	molecular	ADJ
admet-529	512	7	design	design	NOUN
admet-529	512	8	26	26	NUM
admet-529	512	9	(	(	PUNCT
admet-529	512	10	2012	2012	NUM
admet-529	512	11	)	)	PUNCT
admet-529	512	12	311	311	NUM
admet-529	512	13	-	-	SYM
admet-529	512	14	318	318	NUM
admet-529	512	15	.	.	PUNCT
admet-529	513	1	[	[	X
admet-529	513	2	74	74	NUM
admet-529	513	3	]	]	PUNCT
admet-529	513	4	s.	s.	PROPN
admet-529	513	5	prasanna	prasanna	PROPN
admet-529	513	6	,	,	PUNCT
admet-529	513	7	r.j	r.j	PROPN
admet-529	513	8	.	.	PROPN
admet-529	513	9	doerksen	doerksen	PROPN
admet-529	513	10	.	.	PUNCT
admet-529	514	1	topological	topological	ADJ
admet-529	514	2	polar	polar	ADJ
admet-529	514	3	surface	surface	NOUN
admet-529	514	4	area	area	NOUN
admet-529	514	5	:	:	PUNCT
admet-529	514	6	a	a	DET
admet-529	514	7	useful	useful	ADJ
admet-529	514	8	descriptor	descriptor	NOUN
admet-529	514	9	in	in	ADP
admet-529	514	10	2d	2d	NOUN
admet-529	514	11	-	-	PUNCT
admet-529	514	12	qsar	qsar	NOUN
admet-529	514	13	.	.	PUNCT
admet-529	515	1	curr	curr	PROPN
admet-529	515	2	med	med	PROPN
admet-529	515	3	chem	chem	NOUN
admet-529	515	4	16	16	NUM
admet-529	515	5	(	(	PUNCT
admet-529	515	6	2009	2009	NUM
admet-529	515	7	)	)	PUNCT
admet-529	515	8	21	21	NUM
admet-529	515	9	-	-	SYM
admet-529	515	10	41	41	NUM
admet-529	515	11	.	.	PUNCT
admet-529	516	1	[	[	X
admet-529	516	2	75	75	NUM
admet-529	516	3	]	]	PUNCT
admet-529	516	4	j.	j.	PROPN
admet-529	516	5	fernandes	fernandes	PROPN
admet-529	516	6	,	,	PUNCT
admet-529	516	7	c.r	c.r	PROPN
admet-529	516	8	.	.	PROPN
admet-529	516	9	gattass	gattass	PROPN
admet-529	516	10	.	.	PUNCT
admet-529	517	1	topological	topological	ADJ
admet-529	517	2	polar	polar	ADJ
admet-529	517	3	surface	surface	NOUN
admet-529	517	4	area	area	NOUN
admet-529	517	5	defines	define	VERB
admet-529	517	6	substrate	substrate	NOUN
admet-529	517	7	transport	transport	NOUN
admet-529	517	8	by	by	ADP
admet-529	517	9	multidrug	multidrug	NOUN
admet-529	517	10	resistance	resistance	NOUN
admet-529	517	11	associated	associate	VERB
admet-529	517	12	protein	protein	NOUN
admet-529	517	13	1	1	NUM
admet-529	517	14	(	(	PUNCT
admet-529	517	15	mrp1	mrp1	NOUN
admet-529	517	16	/	/	SYM
admet-529	517	17	abcc1	abcc1	PROPN
admet-529	517	18	)	)	PUNCT
admet-529	517	19	.	.	PUNCT
admet-529	518	1	j	j	PROPN
admet-529	518	2	med	med	PROPN
admet-529	518	3	chem	chem	NOUN
admet-529	518	4	52	52	NUM
admet-529	518	5	(	(	PUNCT
admet-529	518	6	2009	2009	NUM
admet-529	518	7	)	)	PUNCT
admet-529	518	8	1214	1214	NUM
admet-529	518	9	-	-	SYM
admet-529	518	10	1218	1218	NUM
admet-529	518	11	.	.	PUNCT
admet-529	519	1	[	[	X
admet-529	519	2	76	76	NUM
admet-529	519	3	]	]	X
admet-529	519	4	d.f	d.f	PROPN
admet-529	519	5	.	.	PROPN
admet-529	519	6	veber	veber	PROPN
admet-529	519	7	,	,	PUNCT
admet-529	519	8	s.r	s.r	PROPN
admet-529	519	9	.	.	PROPN
admet-529	519	10	johnson	johnson	PROPN
admet-529	519	11	,	,	PUNCT
admet-529	519	12	h.y	h.y	PROPN
admet-529	519	13	.	.	PROPN
admet-529	519	14	cheng	cheng	PROPN
admet-529	519	15	,	,	PUNCT
admet-529	519	16	b.r	b.r	PROPN
admet-529	519	17	.	.	PROPN
admet-529	519	18	smith	smith	PROPN
admet-529	519	19	,	,	PUNCT
admet-529	519	20	k.w	k.w	PROPN
admet-529	519	21	.	.	PROPN
admet-529	519	22	ward	ward	PROPN
admet-529	519	23	,	,	PUNCT
admet-529	519	24	k.d	k.d	PROPN
admet-529	519	25	.	.	PROPN
admet-529	519	26	kopple	kopple	PROPN
admet-529	519	27	.	.	PUNCT
admet-529	520	1	molecular	molecular	ADJ
admet-529	520	2	properties	property	NOUN
admet-529	520	3	that	that	PRON
admet-529	520	4	influence	influence	VERB
admet-529	520	5	the	the	DET
admet-529	520	6	oral	oral	ADJ
admet-529	520	7	bioavailability	bioavailability	NOUN
admet-529	520	8	of	of	ADP
admet-529	520	9	drug	drug	NOUN
admet-529	520	10	candidates	candidate	NOUN
admet-529	520	11	.	.	PUNCT
admet-529	521	1	j	j	PROPN
admet-529	521	2	med	med	PROPN
admet-529	521	3	chem	chem	NOUN
admet-529	521	4	45	45	NUM
admet-529	521	5	(	(	PUNCT
admet-529	521	6	2002	2002	NUM
admet-529	521	7	)	)	PUNCT
admet-529	521	8	2615	2615	NUM
admet-529	521	9	-	-	SYM
admet-529	521	10	2623	2623	NUM
admet-529	521	11	.	.	PUNCT
admet-529	522	1	[	[	X
admet-529	522	2	77	77	NUM
admet-529	522	3	]	]	X
admet-529	522	4	h.	h.	PROPN
admet-529	522	5	van	van	PROPN
admet-529	522	6	de	de	PROPN
admet-529	522	7	waterbeemd	waterbeemd	PROPN
admet-529	522	8	,	,	PUNCT
admet-529	522	9	g.	g.	PROPN
admet-529	522	10	camenisch	camenisch	PROPN
admet-529	522	11	,	,	PUNCT
admet-529	522	12	g.	g.	PROPN
admet-529	522	13	folkers	folkers	PROPN
admet-529	522	14	,	,	PUNCT
admet-529	522	15	j.r	j.r	PROPN
admet-529	522	16	.	.	PROPN
admet-529	522	17	chretien	chretien	PROPN
admet-529	522	18	,	,	PUNCT
admet-529	522	19	o.a	o.a	PROPN
admet-529	522	20	.	.	PROPN
admet-529	522	21	raevsky	raevsky	PROPN
admet-529	522	22	.	.	PUNCT
admet-529	523	1	estimation	estimation	NOUN
admet-529	523	2	of	of	ADP
admet-529	523	3	bloodbrain	bloodbrain	NOUN
admet-529	523	4	barrier	barrier	NOUN
admet-529	523	5	crossing	crossing	NOUN
admet-529	523	6	of	of	ADP
admet-529	523	7	drugs	drug	NOUN
admet-529	523	8	using	use	VERB
admet-529	523	9	molecular	molecular	ADJ
admet-529	523	10	size	size	NOUN
admet-529	523	11	and	and	CCONJ
admet-529	523	12	shape	shape	NOUN
admet-529	523	13	,	,	PUNCT
admet-529	523	14	and	and	CCONJ
admet-529	523	15	h	h	NOUN
admet-529	523	16	-	-	PUNCT
admet-529	523	17	bonding	bond	VERB
admet-529	523	18	descriptors	descriptor	NOUN
admet-529	523	19	.	.	PUNCT
admet-529	524	1	j	j	PROPN
admet-529	524	2	drug	drug	PROPN
admet-529	524	3	target	target	NOUN
admet-529	524	4	6	6	NUM
admet-529	524	5	(	(	PUNCT
admet-529	524	6	1998	1998	NUM
admet-529	524	7	)	)	PUNCT
admet-529	524	8	151	151	NUM
admet-529	524	9	-	-	SYM
admet-529	524	10	165	165	NUM
admet-529	524	11	.	.	PUNCT
admet-529	525	1	[	[	X
admet-529	525	2	78	78	NUM
admet-529	525	3	]	]	X
admet-529	525	4	t.t	t.t	PROPN
admet-529	525	5	.	.	PROPN
admet-529	525	6	wager	wager	PROPN
admet-529	525	7	,	,	PUNCT
admet-529	525	8	x.	x.	PROPN
admet-529	525	9	hou	hou	PROPN
admet-529	525	10	,	,	PUNCT
admet-529	525	11	p.r	p.r	PROPN
admet-529	525	12	.	.	PROPN
admet-529	525	13	verhoest	verhoest	PROPN
admet-529	525	14	,	,	PUNCT
admet-529	525	15	a.	a.	PROPN
admet-529	525	16	villalobos	villalobos	PROPN
admet-529	525	17	.	.	PUNCT
admet-529	526	1	central	central	ADJ
admet-529	526	2	nervous	nervous	ADJ
admet-529	526	3	system	system	NOUN
admet-529	526	4	multiparameter	multiparameter	NOUN
admet-529	526	5	optimization	optimization	NOUN
admet-529	526	6	desirability	desirability	NOUN
admet-529	526	7	:	:	PUNCT
admet-529	526	8	application	application	NOUN
admet-529	526	9	in	in	ADP
admet-529	526	10	drug	drug	NOUN
admet-529	526	11	discovery	discovery	NOUN
admet-529	526	12	.	.	PUNCT
admet-529	527	1	acs	acs	PROPN
admet-529	527	2	chem	chem	NOUN
admet-529	527	3	neurosci	neurosci	VERB
admet-529	527	4	7	7	NUM
admet-529	527	5	(	(	PUNCT
admet-529	527	6	2016	2016	NUM
admet-529	527	7	)	)	PUNCT
admet-529	527	8	767	767	NUM
admet-529	527	9	-	-	SYM
admet-529	527	10	775	775	NUM
admet-529	527	11	.	.	PUNCT
admet-529	528	1	[	[	X
admet-529	528	2	79	79	NUM
admet-529	528	3	]	]	PUNCT
admet-529	528	4	j.	j.	PROPN
admet-529	528	5	drews	drews	PROPN
admet-529	528	6	.	.	PUNCT
admet-529	529	1	stategic	stategic	ADJ
admet-529	529	2	trends	trend	NOUN
admet-529	529	3	in	in	ADP
admet-529	529	4	the	the	DET
admet-529	529	5	drug	drug	NOUN
admet-529	529	6	industry	industry	NOUN
admet-529	529	7	.	.	PUNCT
admet-529	530	1	drug	drug	NOUN
admet-529	530	2	discov	discov	PROPN
admet-529	530	3	today	today	NOUN
admet-529	530	4	8	8	NUM
admet-529	530	5	(	(	PUNCT
admet-529	530	6	2003	2003	NUM
admet-529	530	7	)	)	PUNCT
admet-529	530	8	411	411	NUM
admet-529	530	9	-	-	SYM
admet-529	530	10	420	420	NUM
admet-529	530	11	.	.	PUNCT
admet-529	531	1	[	[	X
admet-529	531	2	80	80	NUM
admet-529	531	3	]	]	X
admet-529	531	4	g.h	g.h	PROPN
admet-529	531	5	.	.	PROPN
admet-529	531	6	goetz	goetz	PROPN
admet-529	531	7	,	,	PUNCT
admet-529	531	8	w.	w.	PROPN
admet-529	531	9	farrell	farrell	PROPN
admet-529	531	10	,	,	PUNCT
admet-529	531	11	m.	m.	NOUN
admet-529	531	12	shalaeva	shalaeva	PROPN
admet-529	531	13	,	,	PUNCT
admet-529	531	14	s.	s.	PROPN
admet-529	531	15	sciabola	sciabola	PROPN
admet-529	531	16	,	,	PUNCT
admet-529	531	17	d.	d.	PROPN
admet-529	531	18	anderson	anderson	PROPN
admet-529	531	19	,	,	PUNCT
admet-529	531	20	j.	j.	PROPN
admet-529	531	21	yan	yan	PROPN
admet-529	531	22	,	,	PUNCT
admet-529	531	23	l.	l.	PROPN
admet-529	531	24	philippe	philippe	PROPN
admet-529	531	25	,	,	PUNCT
admet-529	531	26	m.j	m.j	PROPN
admet-529	531	27	.	.	PROPN
admet-529	531	28	shapiro	shapiro	PROPN
admet-529	531	29	.	.	PUNCT
admet-529	532	1	high	high	ADJ
admet-529	532	2	throughput	throughput	NOUN
admet-529	532	3	method	method	NOUN
admet-529	532	4	for	for	ADP
admet-529	532	5	the	the	DET
admet-529	532	6	indirect	indirect	ADJ
admet-529	532	7	detection	detection	NOUN
admet-529	532	8	of	of	ADP
admet-529	532	9	intramolecular	intramolecular	ADJ
admet-529	532	10	hydrogen	hydrogen	NOUN
admet-529	532	11	bonding	bonding	NOUN
admet-529	532	12	.	.	PUNCT
admet-529	533	1	journal	journal	NOUN
admet-529	533	2	of	of	ADP
admet-529	533	3	medicinal	medicinal	ADJ
admet-529	533	4	chemistry	chemistry	NOUN
admet-529	533	5	57	57	NUM
admet-529	533	6	(	(	PUNCT
admet-529	533	7	2014	2014	NUM
admet-529	533	8	)	)	PUNCT
admet-529	533	9	2920	2920	NUM
admet-529	533	10	-	-	SYM
admet-529	533	11	2929	2929	NUM
admet-529	533	12	.	.	PUNCT
admet-529	534	1	admet	admet	PROPN
admet-529	534	2	&	&	CCONJ
admet-529	534	3	dmpk	dmpk	PROPN
admet-529	534	4	6(2	6(2	NUM
admet-529	534	5	)	)	PUNCT
admet-529	534	6	(	(	PUNCT
admet-529	534	7	2018	2018	NUM
admet-529	534	8	)	)	PUNCT
admet-529	534	9	85	85	NUM
admet-529	534	10	-	-	SYM
admet-529	534	11	104	104	NUM
admet-529	534	12	leveraging	leverage	VERB
admet-529	534	13	chromatography	chromatography	NOUN
admet-529	534	14	physchem	physchem	NOUN
admet-529	534	15	properties	property	NOUN
admet-529	534	16	in	in	ADP
admet-529	534	17	drug	drug	NOUN
admet-529	534	18	design	design	NOUN
admet-529	534	19	doi	doi	NOUN
admet-529	534	20	:	:	PUNCT
admet-529	534	21	10.5599	10.5599	NUM
admet-529	534	22	/	/	SYM
admet-529	534	23	admet.529	admet.529	NOUN
admet-529	534	24	103	103	NUM
admet-529	534	25	[	[	X
admet-529	534	26	81	81	NUM
admet-529	534	27	]	]	PUNCT
admet-529	534	28	a.	a.	PROPN
admet-529	534	29	alex	alex	PROPN
admet-529	534	30	,	,	PUNCT
admet-529	534	31	d.s	d.s	PROPN
admet-529	534	32	.	.	PROPN
admet-529	534	33	millan	millan	PROPN
admet-529	534	34	,	,	PUNCT
admet-529	534	35	m.	m.	NOUN
admet-529	534	36	perez	perez	PROPN
admet-529	534	37	,	,	PUNCT
admet-529	534	38	f.	f.	PROPN
admet-529	534	39	wakenhut	wakenhut	PROPN
admet-529	534	40	,	,	PUNCT
admet-529	534	41	g.a	g.a	PROPN
admet-529	534	42	.	.	PROPN
admet-529	534	43	whitlock	whitlock	PROPN
admet-529	534	44	.	.	PUNCT
admet-529	535	1	intramolecular	intramolecular	ADJ
admet-529	535	2	hydrogen	hydrogen	NOUN
admet-529	535	3	bonding	bonding	NOUN
admet-529	535	4	to	to	PART
admet-529	535	5	improve	improve	VERB
admet-529	535	6	membrane	membrane	NOUN
admet-529	535	7	permeability	permeability	NOUN
admet-529	535	8	and	and	CCONJ
admet-529	535	9	absorption	absorption	NOUN
admet-529	535	10	in	in	ADP
admet-529	535	11	beyond	beyond	ADP
admet-529	535	12	rule	rule	NOUN
admet-529	535	13	of	of	ADP
admet-529	535	14	five	five	NUM
admet-529	535	15	chemical	chemical	ADJ
admet-529	535	16	space	space	NOUN
admet-529	535	17	.	.	PUNCT
admet-529	536	1	medchemcomm	medchemcomm	NOUN
admet-529	536	2	2	2	NUM
admet-529	536	3	(	(	PUNCT
admet-529	536	4	2011	2011	NUM
admet-529	536	5	)	)	PUNCT
admet-529	536	6	669	669	NUM
admet-529	536	7	-	-	SYM
admet-529	536	8	674	674	NUM
admet-529	536	9	.	.	PUNCT
admet-529	537	1	[	[	X
admet-529	537	2	82	82	NUM
admet-529	537	3	]	]	X
admet-529	537	4	b.	b.	PROPN
admet-529	537	5	kuhn	kuhn	PROPN
admet-529	537	6	,	,	PUNCT
admet-529	537	7	p.	p.	PROPN
admet-529	537	8	mohr	mohr	PROPN
admet-529	537	9	,	,	PUNCT
admet-529	537	10	m.	m.	NOUN
admet-529	537	11	stahl	stahl	PROPN
admet-529	537	12	.	.	PUNCT
admet-529	538	1	intramolecular	intramolecular	ADJ
admet-529	538	2	hydrogen	hydrogen	NOUN
admet-529	538	3	bonding	bonding	NOUN
admet-529	538	4	in	in	ADP
admet-529	538	5	medicinal	medicinal	ADJ
admet-529	538	6	chemistry	chemistry	NOUN
admet-529	538	7	.	.	PUNCT
admet-529	539	1	journal	journal	PROPN
admet-529	539	2	of	of	ADP
admet-529	539	3	medicinal	medicinal	ADJ
admet-529	539	4	chemistry	chemistry	NOUN
admet-529	539	5	53	53	NUM
admet-529	539	6	(	(	PUNCT
admet-529	539	7	2010	2010	NUM
admet-529	539	8	)	)	PUNCT
admet-529	539	9	2601	2601	NUM
admet-529	539	10	-	-	SYM
admet-529	539	11	2611	2611	NUM
admet-529	539	12	.	.	PUNCT
admet-529	540	1	[	[	X
admet-529	540	2	83	83	NUM
admet-529	540	3	]	]	SYM
admet-529	540	4	s.b	s.b	PROPN
admet-529	540	5	.	.	PROPN
admet-529	540	6	rafi	rafi	PROPN
admet-529	540	7	,	,	PUNCT
admet-529	540	8	b.r	b.r	PROPN
admet-529	540	9	.	.	PROPN
admet-529	540	10	hearn	hearn	PROPN
admet-529	540	11	,	,	PUNCT
admet-529	540	12	p.	p.	NOUN
admet-529	540	13	vedantham	vedantham	NOUN
admet-529	540	14	,	,	PUNCT
admet-529	540	15	m.p	m.p	PROPN
admet-529	540	16	.	.	PROPN
admet-529	540	17	jacobson	jacobson	PROPN
admet-529	540	18	,	,	PUNCT
admet-529	540	19	a.r	a.r	PROPN
admet-529	540	20	.	.	PROPN
admet-529	540	21	renslo	renslo	PROPN
admet-529	540	22	.	.	PUNCT
admet-529	541	1	predicting	predict	VERB
admet-529	541	2	and	and	CCONJ
admet-529	541	3	improving	improve	VERB
admet-529	541	4	the	the	DET
admet-529	541	5	membrane	membrane	NOUN
admet-529	541	6	permeability	permeability	NOUN
admet-529	541	7	of	of	ADP
admet-529	541	8	peptidic	peptidic	ADJ
admet-529	541	9	small	small	ADJ
admet-529	541	10	molecules	molecule	NOUN
admet-529	541	11	.	.	PUNCT
admet-529	542	1	journal	journal	NOUN
admet-529	542	2	of	of	ADP
admet-529	542	3	medicinal	medicinal	ADJ
admet-529	542	4	chemistry	chemistry	NOUN
admet-529	542	5	55	55	NUM
admet-529	542	6	(	(	PUNCT
admet-529	542	7	2012	2012	NUM
admet-529	542	8	)	)	PUNCT
admet-529	542	9	3163	3163	NUM
admet-529	542	10	-	-	SYM
admet-529	542	11	3169	3169	NUM
admet-529	542	12	.	.	PUNCT
admet-529	543	1	[	[	X
admet-529	543	2	84	84	NUM
admet-529	543	3	]	]	PUNCT
admet-529	543	4	t.	t.	NOUN
admet-529	543	5	rezai	rezai	NOUN
admet-529	543	6	,	,	PUNCT
admet-529	543	7	j.e	j.e	PROPN
admet-529	543	8	.	.	PROPN
admet-529	543	9	bock	bock	PROPN
admet-529	543	10	,	,	PUNCT
admet-529	543	11	m.v	m.v	PROPN
admet-529	543	12	.	.	PROPN
admet-529	543	13	zhou	zhou	PROPN
admet-529	543	14	,	,	PUNCT
admet-529	543	15	c.	c.	PROPN
admet-529	543	16	kalyanaraman	kalyanaraman	PROPN
admet-529	543	17	,	,	PUNCT
admet-529	543	18	r.s	r.s	PROPN
admet-529	543	19	.	.	PROPN
admet-529	543	20	lokey	lokey	PROPN
admet-529	543	21	,	,	PUNCT
admet-529	543	22	m.p	m.p	PROPN
admet-529	543	23	.	.	PROPN
admet-529	543	24	jacobson	jacobson	PROPN
admet-529	543	25	.	.	PUNCT
admet-529	544	1	conformational	conformational	ADJ
admet-529	544	2	flexibility	flexibility	NOUN
admet-529	544	3	,	,	PUNCT
admet-529	544	4	internal	internal	ADJ
admet-529	544	5	hydrogen	hydrogen	NOUN
admet-529	544	6	bonding	bonding	NOUN
admet-529	544	7	,	,	PUNCT
admet-529	544	8	and	and	CCONJ
admet-529	544	9	passive	passive	ADJ
admet-529	544	10	membrane	membrane	NOUN
admet-529	544	11	permeability	permeability	NOUN
admet-529	544	12	:	:	PUNCT
admet-529	544	13	  	  	SPACE
admet-529	544	14	successful	successful	ADJ
admet-529	544	15	in	in	ADP
admet-529	544	16	silico	silico	NOUN
admet-529	544	17	prediction	prediction	NOUN
admet-529	544	18	of	of	ADP
admet-529	544	19	the	the	DET
admet-529	544	20	relative	relative	ADJ
admet-529	544	21	permeabilities	permeability	NOUN
admet-529	544	22	of	of	ADP
admet-529	544	23	cyclic	cyclic	ADJ
admet-529	544	24	peptides	peptide	NOUN
admet-529	544	25	.	.	PUNCT
admet-529	545	1	journal	journal	NOUN
admet-529	545	2	of	of	ADP
admet-529	545	3	the	the	DET
admet-529	545	4	american	american	PROPN
admet-529	545	5	chemical	chemical	PROPN
admet-529	545	6	society	society	PROPN
admet-529	545	7	128	128	NUM
admet-529	545	8	(	(	PUNCT
admet-529	545	9	2006	2006	NUM
admet-529	545	10	)	)	PUNCT
admet-529	545	11	14073	14073	NUM
admet-529	545	12	-	-	SYM
admet-529	545	13	14080	14080	NUM
admet-529	545	14	.	.	PUNCT
admet-529	546	1	[	[	X
admet-529	546	2	85	85	NUM
admet-529	546	3	]	]	PUNCT
admet-529	546	4	t.	t.	NOUN
admet-529	546	5	rezai	rezai	PROPN
admet-529	546	6	,	,	PUNCT
admet-529	546	7	b.	b.	PROPN
admet-529	546	8	yu	yu	PROPN
admet-529	546	9	,	,	PUNCT
admet-529	546	10	g.l	g.l	PROPN
admet-529	546	11	.	.	PROPN
admet-529	546	12	millhauser	millhauser	PROPN
admet-529	546	13	,	,	PUNCT
admet-529	546	14	m.p	m.p	PROPN
admet-529	546	15	.	.	PROPN
admet-529	546	16	jacobson	jacobson	PROPN
admet-529	546	17	,	,	PUNCT
admet-529	546	18	r.s	r.s	PROPN
admet-529	546	19	.	.	PROPN
admet-529	546	20	lokey	lokey	PROPN
admet-529	546	21	.	.	PUNCT
admet-529	547	1	testing	test	VERB
admet-529	547	2	the	the	DET
admet-529	547	3	conformational	conformational	ADJ
admet-529	547	4	hypothesis	hypothesis	NOUN
admet-529	547	5	of	of	ADP
admet-529	547	6	passive	passive	ADJ
admet-529	547	7	membrane	membrane	NOUN
admet-529	547	8	permeability	permeability	NOUN
admet-529	547	9	using	use	VERB
admet-529	547	10	synthetic	synthetic	ADJ
admet-529	547	11	cyclic	cyclic	ADJ
admet-529	547	12	peptide	peptide	NOUN
admet-529	547	13	diastereomers	diastereomer	NOUN
admet-529	547	14	.	.	PUNCT
admet-529	548	1	j	j	PROPN
admet-529	548	2	am	be	AUX
admet-529	548	3	chem	chem	NOUN
admet-529	548	4	soc	soc	NOUN
admet-529	548	5	128	128	NUM
admet-529	548	6	(	(	PUNCT
admet-529	548	7	2006	2006	NUM
admet-529	548	8	)	)	PUNCT
admet-529	548	9	2510	2510	NUM
admet-529	548	10	-	-	SYM
admet-529	548	11	2511	2511	NUM
admet-529	548	12	.	.	PUNCT
admet-529	549	1	[	[	X
admet-529	549	2	86	86	NUM
admet-529	549	3	]	]	X
admet-529	549	4	h.	h.	PROPN
admet-529	549	5	cheng	cheng	PROPN
admet-529	549	6	,	,	PUNCT
admet-529	549	7	j.e	j.e	PROPN
admet-529	549	8	.	.	PROPN
admet-529	549	9	hoffman	hoffman	PROPN
admet-529	549	10	,	,	PUNCT
admet-529	549	11	p.t	p.t	PROPN
admet-529	549	12	.	.	PROPN
admet-529	549	13	le	le	PROPN
admet-529	549	14	,	,	PUNCT
admet-529	549	15	m.	m.	NOUN
admet-529	549	16	pairish	pairish	PROPN
admet-529	549	17	,	,	PUNCT
admet-529	549	18	r.	r.	PROPN
admet-529	549	19	kania	kania	PROPN
admet-529	549	20	,	,	PUNCT
admet-529	549	21	w.	w.	PROPN
admet-529	549	22	farrell	farrell	PROPN
admet-529	549	23	,	,	PUNCT
admet-529	549	24	s.	s.	PROPN
admet-529	549	25	bagrodia	bagrodia	PROPN
admet-529	549	26	,	,	PUNCT
admet-529	549	27	j.	j.	PROPN
admet-529	549	28	yuan	yuan	PROPN
admet-529	549	29	,	,	PUNCT
admet-529	549	30	s.	s.	PROPN
admet-529	549	31	sun	sun	PROPN
admet-529	549	32	,	,	PUNCT
admet-529	549	33	e.	e.	PROPN
admet-529	549	34	zhang	zhang	PROPN
admet-529	549	35	,	,	PUNCT
admet-529	549	36	c.	c.	PROPN
admet-529	549	37	xiang	xiang	PROPN
admet-529	549	38	,	,	PUNCT
admet-529	549	39	d.	d.	PROPN
admet-529	549	40	dalvie	dalvie	PROPN
admet-529	549	41	,	,	PUNCT
admet-529	549	42	s.v	s.v	PROPN
admet-529	549	43	.	.	PROPN
admet-529	549	44	rahavendran	rahavendran	PROPN
admet-529	549	45	.	.	PUNCT
admet-529	550	1	structure	structure	NOUN
admet-529	550	2	-	-	PUNCT
admet-529	550	3	based	base	VERB
admet-529	550	4	design	design	NOUN
admet-529	550	5	,	,	PUNCT
admet-529	550	6	sar	sar	NOUN
admet-529	550	7	analysis	analysis	NOUN
admet-529	550	8	and	and	CCONJ
admet-529	550	9	antitumor	antitumor	NOUN
admet-529	550	10	activity	activity	NOUN
admet-529	550	11	of	of	ADP
admet-529	550	12	pi3k	pi3k	PROPN
admet-529	550	13	/	/	SYM
admet-529	550	14	mtor	mtor	NOUN
admet-529	550	15	dual	dual	ADJ
admet-529	550	16	inhibitors	inhibitor	NOUN
admet-529	550	17	from	from	ADP
admet-529	550	18	4	4	NUM
admet-529	550	19	-	-	PUNCT
admet-529	550	20	methylpyridopyrimidinone	methylpyridopyrimidinone	NOUN
admet-529	550	21	series	series	NOUN
admet-529	550	22	.	.	PUNCT
admet-529	551	1	bioorganic	bioorganic	PROPN
admet-529	551	2	&	&	CCONJ
admet-529	551	3	medicinal	medicinal	ADJ
admet-529	551	4	chemistry	chemistry	NOUN
admet-529	551	5	letters	letter	NOUN
admet-529	551	6	23	23	NUM
admet-529	551	7	(	(	PUNCT
admet-529	551	8	2013	2013	NUM
admet-529	551	9	)	)	PUNCT
admet-529	551	10	2787	2787	NUM
admet-529	551	11	-	-	SYM
admet-529	551	12	2792	2792	NUM
admet-529	551	13	.	.	PUNCT
admet-529	552	1	[	[	X
admet-529	552	2	87	87	NUM
admet-529	552	3	]	]	PUNCT
admet-529	552	4	f.	f.	NOUN
admet-529	552	5	wakenhut	wakenhut	PROPN
admet-529	552	6	,	,	PUNCT
admet-529	552	7	t.d	t.d	PROPN
admet-529	552	8	.	.	PROPN
admet-529	552	9	tran	tran	PROPN
admet-529	552	10	,	,	PUNCT
admet-529	552	11	c.	c.	PROPN
admet-529	552	12	pickford	pickford	PROPN
admet-529	552	13	,	,	PUNCT
admet-529	552	14	s.	s.	PROPN
admet-529	552	15	shaw	shaw	PROPN
admet-529	552	16	,	,	PUNCT
admet-529	552	17	m.	m.	NOUN
admet-529	552	18	westby	westby	PROPN
admet-529	552	19	,	,	PUNCT
admet-529	552	20	c.	c.	PROPN
admet-529	552	21	smith	smith	PROPN
admet-529	552	22	-	-	PUNCT
admet-529	552	23	burchnell	burchnell	PROPN
admet-529	552	24	,	,	PUNCT
admet-529	552	25	l.	l.	PROPN
admet-529	552	26	watson	watson	PROPN
admet-529	552	27	,	,	PUNCT
admet-529	552	28	m.	m.	NOUN
admet-529	552	29	paradowski	paradowski	PROPN
admet-529	552	30	,	,	PUNCT
admet-529	552	31	j.	j.	PROPN
admet-529	552	32	milbank	milbank	PROPN
admet-529	552	33	,	,	PUNCT
admet-529	552	34	d.	d.	PROPN
admet-529	552	35	stonehouse	stonehouse	PROPN
admet-529	552	36	,	,	PUNCT
admet-529	552	37	k.	k.	PROPN
admet-529	552	38	cheung	cheung	PROPN
admet-529	552	39	,	,	PUNCT
admet-529	552	40	r.	r.	PROPN
admet-529	552	41	wybrow	wybrow	PROPN
admet-529	552	42	,	,	PUNCT
admet-529	552	43	f.	f.	PROPN
admet-529	552	44	daverio	daverio	PROPN
admet-529	552	45	,	,	PUNCT
admet-529	552	46	s.	s.	PROPN
admet-529	552	47	crook	crook	PROPN
admet-529	552	48	,	,	PUNCT
admet-529	552	49	k.	k.	PROPN
admet-529	552	50	statham	statham	PROPN
admet-529	552	51	,	,	PUNCT
admet-529	552	52	d.	d.	PROPN
admet-529	552	53	leese	leese	PROPN
admet-529	552	54	,	,	PUNCT
admet-529	552	55	d.	d.	PROPN
admet-529	552	56	stead	stead	PROPN
admet-529	552	57	,	,	PUNCT
admet-529	552	58	f.	f.	PROPN
admet-529	552	59	adam	adam	PROPN
admet-529	552	60	,	,	PUNCT
admet-529	552	61	d.	d.	PROPN
admet-529	552	62	hay	hay	PROPN
admet-529	552	63	,	,	PUNCT
admet-529	552	64	l.r	l.r	PROPN
admet-529	552	65	.	.	PROPN
admet-529	552	66	roberts	roberts	PROPN
admet-529	552	67	,	,	PUNCT
admet-529	552	68	j.y	j.y	PROPN
admet-529	552	69	.	.	PROPN
admet-529	552	70	chiva	chiva	PROPN
admet-529	552	71	,	,	PUNCT
admet-529	552	72	c.	c.	PROPN
admet-529	552	73	nichols	nichols	PROPN
admet-529	552	74	,	,	PUNCT
admet-529	552	75	d.c	d.c	PROPN
admet-529	552	76	.	.	PROPN
admet-529	552	77	blakemore	blakemore	PROPN
admet-529	552	78	,	,	PUNCT
admet-529	552	79	g.h	g.h	PROPN
admet-529	552	80	.	.	PROPN
admet-529	552	81	goetz	goetz	PROPN
admet-529	552	82	,	,	PUNCT
admet-529	552	83	y.	y.	PROPN
admet-529	552	84	che	che	PROPN
admet-529	552	85	,	,	PUNCT
admet-529	552	86	i.	i.	PROPN
admet-529	552	87	gardner	gardner	PROPN
admet-529	552	88	,	,	PUNCT
admet-529	552	89	s.	s.	PROPN
admet-529	552	90	dayal	dayal	PROPN
admet-529	552	91	,	,	PUNCT
admet-529	552	92	a.	a.	NOUN
admet-529	552	93	pike	pike	NOUN
admet-529	552	94	,	,	PUNCT
admet-529	552	95	r.	r.	PROPN
admet-529	552	96	webster	webster	PROPN
admet-529	552	97	,	,	PUNCT
admet-529	552	98	d.c	d.c	PROPN
admet-529	552	99	.	.	PUNCT
admet-529	552	100	pryde	pryde	PROPN
admet-529	552	101	.	.	PUNCT
admet-529	553	1	the	the	DET
admet-529	553	2	discovery	discovery	NOUN
admet-529	553	3	of	of	ADP
admet-529	553	4	potent	potent	ADJ
admet-529	553	5	nonstructural	nonstructural	ADJ
admet-529	553	6	protein	protein	NOUN
admet-529	553	7	5a	5a	NOUN
admet-529	553	8	(	(	PUNCT
admet-529	553	9	ns5a	ns5a	NOUN
admet-529	553	10	)	)	PUNCT
admet-529	553	11	inhibitors	inhibitor	NOUN
admet-529	553	12	with	with	ADP
admet-529	553	13	a	a	DET
admet-529	553	14	unique	unique	ADJ
admet-529	553	15	resistance	resistance	NOUN
admet-529	553	16	profile	profile	NOUN
admet-529	553	17	-	-	PUNCT
admet-529	553	18	part	part	NOUN
admet-529	553	19	2	2	NUM
admet-529	553	20	.	.	PUNCT
admet-529	553	21	chemmedchem	chemmedchem	PROPN
admet-529	553	22	9	9	NUM
admet-529	553	23	(	(	PUNCT
admet-529	553	24	2014	2014	NUM
admet-529	553	25	)	)	PUNCT
admet-529	553	26	13871396	13871396	NUM
admet-529	553	27	.	.	PUNCT
admet-529	554	1	[	[	X
admet-529	554	2	88	88	NUM
admet-529	554	3	]	]	X
admet-529	554	4	g.h	g.h	PROPN
admet-529	554	5	.	.	PROPN
admet-529	554	6	goetz	goetz	PROPN
admet-529	554	7	,	,	PUNCT
admet-529	554	8	l.	l.	PROPN
admet-529	554	9	philippe	philippe	PROPN
admet-529	554	10	,	,	PUNCT
admet-529	554	11	m.j	m.j	PROPN
admet-529	554	12	.	.	PROPN
admet-529	554	13	shapiro	shapiro	PROPN
admet-529	554	14	.	.	PUNCT
admet-529	555	1	epsa	epsa	PROPN
admet-529	555	2	:	:	PUNCT
admet-529	555	3	a	a	DET
admet-529	555	4	novel	novel	ADJ
admet-529	555	5	supercritical	supercritical	ADJ
admet-529	555	6	fluid	fluid	NOUN
admet-529	555	7	chromatography	chromatography	NOUN
admet-529	555	8	technique	technique	NOUN
admet-529	555	9	enabling	enable	VERB
admet-529	555	10	the	the	DET
admet-529	555	11	design	design	NOUN
admet-529	555	12	of	of	ADP
admet-529	555	13	permeable	permeable	ADJ
admet-529	555	14	cyclic	cyclic	ADJ
admet-529	555	15	peptides	peptide	NOUN
admet-529	555	16	.	.	PUNCT
admet-529	556	1	acs	acs	PROPN
admet-529	556	2	medicinal	medicinal	ADJ
admet-529	556	3	chemistry	chemistry	NOUN
admet-529	556	4	letters	letter	NOUN
admet-529	556	5	5	5	NUM
admet-529	556	6	(	(	PUNCT
admet-529	556	7	2014	2014	NUM
admet-529	556	8	)	)	PUNCT
admet-529	556	9	11671172	11671172	NUM
admet-529	556	10	.	.	PUNCT
admet-529	557	1	[	[	X
admet-529	557	2	89	89	NUM
admet-529	557	3	]	]	X
admet-529	557	4	d.s	d.s	PROPN
admet-529	557	5	.	.	PROPN
admet-529	557	6	nielsen	nielsen	PROPN
admet-529	557	7	,	,	PUNCT
admet-529	557	8	h.n	h.n	PROPN
admet-529	557	9	.	.	PROPN
admet-529	557	10	hoang	hoang	PROPN
admet-529	557	11	,	,	PUNCT
admet-529	557	12	r.j	r.j	PROPN
admet-529	557	13	.	.	PROPN
admet-529	557	14	lohman	lohman	PROPN
admet-529	557	15	,	,	PUNCT
admet-529	557	16	t.a	t.a	PROPN
admet-529	557	17	.	.	PROPN
admet-529	557	18	hill	hill	PROPN
admet-529	557	19	,	,	PUNCT
admet-529	557	20	a.j	a.j	PROPN
admet-529	557	21	.	.	PROPN
admet-529	557	22	lucke	lucke	PROPN
admet-529	557	23	,	,	PUNCT
admet-529	557	24	d.j	d.j	PROPN
admet-529	557	25	.	.	PROPN
admet-529	557	26	craik	craik	PROPN
admet-529	557	27	,	,	PUNCT
admet-529	557	28	d.j	d.j	PROPN
admet-529	557	29	.	.	PROPN
admet-529	557	30	edmonds	edmonds	PROPN
admet-529	557	31	,	,	PUNCT
admet-529	557	32	d.a	d.a	PROPN
admet-529	557	33	.	.	PROPN
admet-529	557	34	griffith	griffith	PROPN
admet-529	557	35	,	,	PUNCT
admet-529	557	36	c.j	c.j	PROPN
admet-529	557	37	.	.	PROPN
admet-529	557	38	rotter	rotter	PROPN
admet-529	557	39	,	,	PUNCT
admet-529	557	40	r.b	r.b	PROPN
admet-529	557	41	.	.	PUNCT
admet-529	557	42	ruggeri	ruggeri	PROPN
admet-529	557	43	.	.	PUNCT
admet-529	558	1	improving	improve	VERB
admet-529	558	2	on	on	ADP
admet-529	558	3	nature	nature	NOUN
admet-529	558	4	:	:	PUNCT
admet-529	558	5	making	make	VERB
admet-529	558	6	a	a	DET
admet-529	558	7	cyclic	cyclic	ADJ
admet-529	558	8	heptapeptide	heptapeptide	ADJ
admet-529	558	9	orally	orally	ADV
admet-529	558	10	bioavailable	bioavailable	ADJ
admet-529	558	11	.	.	PUNCT
admet-529	559	1	angewandte	angewandte	PROPN
admet-529	559	2	chemie	chemie	PROPN
admet-529	559	3	international	international	PROPN
admet-529	559	4	edition	edition	PROPN
admet-529	559	5	53	53	NUM
admet-529	559	6	(	(	PUNCT
admet-529	559	7	2014	2014	NUM
admet-529	559	8	)	)	PUNCT
admet-529	559	9	12059	12059	NUM
admet-529	559	10	-	-	SYM
admet-529	559	11	12063	12063	NUM
admet-529	559	12	.	.	PUNCT
admet-529	560	1	[	[	X
admet-529	560	2	90	90	NUM
admet-529	560	3	]	]	PUNCT
admet-529	560	4	j.	j.	PROPN
admet-529	560	5	schwochert	schwochert	PROPN
admet-529	560	6	,	,	PUNCT
admet-529	560	7	r.	r.	PROPN
admet-529	560	8	turner	turner	PROPN
admet-529	560	9	,	,	PUNCT
admet-529	560	10	m.	m.	PROPN
admet-529	560	11	thang	thang	PROPN
admet-529	560	12	,	,	PUNCT
admet-529	560	13	r.f	r.f	PROPN
admet-529	560	14	.	.	PROPN
admet-529	560	15	berkeley	berkeley	PROPN
admet-529	560	16	,	,	PUNCT
admet-529	560	17	a.r	a.r	PROPN
admet-529	560	18	.	.	PROPN
admet-529	560	19	ponkey	ponkey	PROPN
admet-529	560	20	,	,	PUNCT
admet-529	560	21	k.m	k.m	PROPN
admet-529	560	22	.	.	PROPN
admet-529	560	23	rodriguez	rodriguez	PROPN
admet-529	560	24	,	,	PUNCT
admet-529	560	25	s.s	s.s	PROPN
admet-529	560	26	.	.	PROPN
admet-529	560	27	leung	leung	PROPN
admet-529	560	28	,	,	PUNCT
admet-529	560	29	b.	b.	PROPN
admet-529	560	30	khunte	khunte	PROPN
admet-529	560	31	,	,	PUNCT
admet-529	560	32	g.	g.	PROPN
admet-529	560	33	goetz	goetz	PROPN
admet-529	560	34	,	,	PUNCT
admet-529	560	35	c.	c.	PROPN
admet-529	560	36	limberakis	limberakis	PROPN
admet-529	560	37	.	.	PUNCT
admet-529	561	1	peptide	peptide	NOUN
admet-529	561	2	to	to	ADP
admet-529	561	3	peptoid	peptoid	ADJ
admet-529	561	4	substitutions	substitution	NOUN
admet-529	561	5	increase	increase	VERB
admet-529	561	6	cell	cell	NOUN
admet-529	561	7	permeability	permeability	NOUN
admet-529	561	8	in	in	ADP
admet-529	561	9	cyclic	cyclic	ADJ
admet-529	561	10	hexapeptides	hexapeptide	NOUN
admet-529	561	11	.	.	PUNCT
admet-529	562	1	organic	organic	ADJ
admet-529	562	2	letters	letter	NOUN
admet-529	562	3	17	17	NUM
admet-529	562	4	(	(	PUNCT
admet-529	562	5	2015	2015	NUM
admet-529	562	6	)	)	PUNCT
admet-529	562	7	2928	2928	NUM
admet-529	562	8	-	-	SYM
admet-529	562	9	2931	2931	NUM
admet-529	562	10	.	.	PUNCT
admet-529	563	1	[	[	X
admet-529	563	2	91	91	NUM
admet-529	563	3	]	]	PUNCT
admet-529	563	4	s.	s.	PROPN
admet-529	563	5	sciabola	sciabola	PROPN
admet-529	563	6	,	,	PUNCT
admet-529	563	7	g.h	g.h	PROPN
admet-529	563	8	.	.	PROPN
admet-529	563	9	goetz	goetz	PROPN
admet-529	563	10	,	,	PUNCT
admet-529	563	11	g.	g.	PROPN
admet-529	563	12	bai	bai	PROPN
admet-529	563	13	,	,	PUNCT
admet-529	563	14	b.n	b.n	PROPN
admet-529	563	15	.	.	PROPN
admet-529	563	16	rogers	rogers	PROPN
admet-529	563	17	,	,	PUNCT
admet-529	563	18	d.l	d.l	PROPN
admet-529	563	19	.	.	PROPN
admet-529	563	20	gray	gray	PROPN
admet-529	563	21	,	,	PUNCT
admet-529	563	22	a.	a.	NOUN
admet-529	563	23	duplantier	duplantier	NOUN
admet-529	563	24	,	,	PUNCT
admet-529	563	25	k.r	k.r	PROPN
admet-529	563	26	.	.	PROPN
admet-529	563	27	fonseca	fonseca	PROPN
admet-529	563	28	,	,	PUNCT
admet-529	563	29	m.a	m.a	PROPN
admet-529	563	30	.	.	PROPN
admet-529	563	31	vanasefrawley	vanasefrawley	PROPN
admet-529	563	32	,	,	PUNCT
admet-529	563	33	n.m	n.m	PROPN
admet-529	563	34	.	.	PROPN
admet-529	563	35	kablaoui	kablaoui	PROPN
admet-529	563	36	.	.	PUNCT
admet-529	564	1	systematic	systematic	ADJ
admet-529	564	2	n	n	CCONJ
admet-529	564	3	-	-	PUNCT
admet-529	564	4	methylation	methylation	NOUN
admet-529	564	5	of	of	ADP
admet-529	564	6	oxytocin	oxytocin	PROPN
admet-529	564	7	:	:	PUNCT
admet-529	564	8	impact	impact	NOUN
admet-529	564	9	on	on	ADP
admet-529	564	10	pharmacology	pharmacology	NOUN
admet-529	564	11	and	and	CCONJ
admet-529	564	12	intramolecular	intramolecular	ADJ
admet-529	564	13	hydrogen	hydrogen	NOUN
admet-529	564	14	bonding	bonding	NOUN
admet-529	564	15	network	network	NOUN
admet-529	564	16	.	.	PUNCT
admet-529	565	1	bioorganic	bioorganic	PROPN
admet-529	565	2	&	&	CCONJ
admet-529	565	3	medicinal	medicinal	ADJ
admet-529	565	4	chemistry	chemistry	NOUN
admet-529	565	5	24	24	NUM
admet-529	565	6	(	(	PUNCT
admet-529	565	7	2016	2016	NUM
admet-529	565	8	)	)	PUNCT
admet-529	565	9	3513	3513	NUM
admet-529	565	10	-	-	SYM
admet-529	565	11	3520	3520	NUM
admet-529	565	12	.	.	PUNCT
admet-529	566	1	[	[	X
admet-529	566	2	92	92	NUM
admet-529	566	3	]	]	X
admet-529	566	4	s.g	s.g	PROPN
admet-529	566	5	.	.	PROPN
admet-529	566	6	sciabola	sciabola	PROPN
admet-529	566	7	,	,	PUNCT
admet-529	566	8	gilles	gille	NOUN
admet-529	566	9	;	;	PUNCT
admet-529	566	10	farrell	farrell	PROPN
admet-529	566	11	,	,	PUNCT
admet-529	566	12	william	william	PROPN
admet-529	566	13	high	high	ADJ
admet-529	566	14	-	-	PUNCT
admet-529	566	15	throughput	throughput	NOUN
admet-529	566	16	method	method	NOUN
admet-529	566	17	for	for	ADP
admet-529	566	18	the	the	DET
admet-529	566	19	indirect	indirect	ADJ
admet-529	566	20	detection	detection	NOUN
admet-529	566	21	of	of	ADP
admet-529	566	22	imhb	imhb	NOUN
admet-529	566	23	.	.	PUNCT
admet-529	567	1	ssc14	ssc14	VERB
admet-529	567	2	14th	14th	ADJ
admet-529	567	3	scandinavian	scandinavian	ADJ
admet-529	567	4	symposium	symposium	NOUN
admet-529	567	5	on	on	ADP
admet-529	567	6	chemometrics	chemometric	NOUN
admet-529	567	7	2015sardinia	2015sardinia	PROPN
admet-529	567	8	,	,	PUNCT
admet-529	567	9	italy	italy	PROPN
admet-529	567	10	,	,	PUNCT
admet-529	567	11	2015	2015	NUM
admet-529	567	12	.	.	PUNCT
admet-529	568	1	[	[	X
admet-529	568	2	93	93	NUM
admet-529	568	3	]	]	PUNCT
admet-529	568	4	g.	g.	PROPN
admet-529	568	5	goetz	goetz	PROPN
admet-529	568	6	.	.	PROPN
admet-529	568	7	epsa	epsa	PROPN
admet-529	568	8	:	:	PUNCT
admet-529	568	9	a	a	DET
admet-529	568	10	novel	novel	ADJ
admet-529	568	11	supercritical	supercritical	ADJ
admet-529	568	12	fluid	fluid	NOUN
admet-529	568	13	chromatography	chromatography	NOUN
admet-529	568	14	technique	technique	NOUN
admet-529	568	15	enabling	enable	VERB
admet-529	568	16	the	the	DET
admet-529	568	17	design	design	NOUN
admet-529	568	18	of	of	ADP
admet-529	568	19	permeable	permeable	ADJ
admet-529	568	20	cyclic	cyclic	ADJ
admet-529	568	21	peptides	peptide	NOUN
admet-529	568	22	.	.	PUNCT
admet-529	569	1	world	world	NOUN
admet-529	569	2	preclinical	preclinical	ADJ
admet-529	569	3	congressboston	congressboston	NOUN
admet-529	569	4	,	,	PUNCT
admet-529	569	5	2016	2016	NUM
admet-529	569	6	.	.	PUNCT
admet-529	570	1	[	[	X
admet-529	570	2	94	94	NUM
admet-529	570	3	]	]	X
admet-529	570	4	d.a	d.a	PROPN
admet-529	570	5	.	.	PROPN
admet-529	570	6	degoey	degoey	PROPN
admet-529	570	7	,	,	PUNCT
admet-529	570	8	h.-j	h.-j	PROPN
admet-529	570	9	.	.	PUNCT
admet-529	571	1	chen	chen	PROPN
admet-529	571	2	,	,	PUNCT
admet-529	571	3	p.b	p.b	PROPN
admet-529	571	4	.	.	PROPN
admet-529	571	5	cox	cox	PROPN
admet-529	571	6	,	,	PUNCT
admet-529	571	7	m.d	m.d	PROPN
admet-529	571	8	.	.	PROPN
admet-529	571	9	wendt	wendt	PROPN
admet-529	571	10	.	.	PUNCT
admet-529	572	1	beyond	beyond	ADP
admet-529	572	2	the	the	DET
admet-529	572	3	rule	rule	NOUN
admet-529	572	4	of	of	ADP
admet-529	572	5	5	5	NUM
admet-529	572	6	:	:	PUNCT
admet-529	572	7	lessons	lesson	NOUN
admet-529	572	8	learned	learn	VERB
admet-529	572	9	from	from	ADP
admet-529	572	10	abbvie	abbvie	PROPN
admet-529	572	11	’s	’s	PART
admet-529	572	12	drugs	drug	NOUN
admet-529	572	13	and	and	CCONJ
admet-529	572	14	compound	compound	NOUN
admet-529	572	15	collection	collection	NOUN
admet-529	572	16	:	:	PUNCT
admet-529	572	17	miniperspective	miniperspective	ADJ
admet-529	572	18	.	.	PUNCT
admet-529	573	1	journal	journal	PROPN
admet-529	573	2	of	of	ADP
admet-529	573	3	medicinal	medicinal	ADJ
admet-529	573	4	chemistry	chemistry	NOUN
admet-529	573	5	(	(	PUNCT
admet-529	573	6	2017	2017	NUM
admet-529	573	7	)	)	PUNCT
admet-529	573	8	.	.	PUNCT
admet-529	574	1	[	[	X
admet-529	574	2	95	95	NUM
admet-529	574	3	]	]	PUNCT
admet-529	574	4	t.	t.	PROPN
admet-529	574	5	vorherr	vorherr	PROPN
admet-529	574	6	,	,	PUNCT
admet-529	574	7	i.	i.	PROPN
admet-529	574	8	lewis	lewis	PROPN
admet-529	574	9	,	,	PUNCT
admet-529	574	10	j.	j.	PROPN
admet-529	574	11	berghausen	berghausen	PROPN
admet-529	574	12	,	,	PUNCT
admet-529	574	13	s.	s.	PROPN
admet-529	574	14	desrayaud	desrayaud	PROPN
admet-529	574	15	,	,	PUNCT
admet-529	574	16	m.	m.	NOUN
admet-529	574	17	schaefer	schaefer	PROPN
admet-529	574	18	.	.	PUNCT
admet-529	575	1	modulation	modulation	NOUN
admet-529	575	2	of	of	ADP
admet-529	575	3	oral	oral	ADJ
admet-529	575	4	bioavailability	bioavailability	NOUN
admet-529	575	5	and	and	CCONJ
admet-529	575	6	metabolism	metabolism	NOUN
admet-529	575	7	for	for	ADP
admet-529	575	8	closely	closely	ADV
admet-529	575	9	related	relate	VERB
admet-529	575	10	cyclic	cyclic	ADJ
admet-529	575	11	hexapeptides	hexapeptide	NOUN
admet-529	575	12	.	.	PUNCT
admet-529	576	1	international	international	ADJ
admet-529	576	2	journal	journal	PROPN
admet-529	576	3	of	of	ADP
admet-529	576	4	peptide	peptide	ADJ
admet-529	576	5	research	research	NOUN
admet-529	576	6	and	and	CCONJ
admet-529	576	7	therapeutics	therapeutic	NOUN
admet-529	576	8	(	(	PUNCT
admet-529	576	9	2017	2017	NUM
admet-529	576	10	)	)	PUNCT
admet-529	576	11	1	1	NUM
admet-529	576	12	-	-	SYM
admet-529	576	13	14	14	NUM
admet-529	576	14	.	.	PUNCT
admet-529	577	1	[	[	X
admet-529	577	2	96	96	NUM
admet-529	577	3	]	]	X
admet-529	577	4	s.c	s.c	PROPN
admet-529	577	5	.	.	PROPN
admet-529	577	6	ha	ha	PROPN
admet-529	577	7	,	,	PUNCT
admet-529	577	8	seth	seth	PROPN
admet-529	577	9	optimizing	optimize	VERB
admet-529	577	10	permeability	permeability	NOUN
admet-529	577	11	of	of	ADP
admet-529	577	12	peptides	peptide	NOUN
admet-529	577	13	.	.	PUNCT
admet-529	578	1	computational	computational	ADJ
admet-529	578	2	drug	drug	NOUN
admet-529	578	3	developmentboston	developmentboston	NOUN
admet-529	578	4	,	,	PUNCT
admet-529	578	5	2015	2015	NUM
admet-529	578	6	.	.	PUNCT
admet-529	579	1	[	[	X
admet-529	579	2	97	97	NUM
admet-529	579	3	]	]	X
admet-529	579	4	j.p.l	j.p.l	PROPN
admet-529	579	5	.	.	PUNCT
admet-529	579	6	kiplinger	kiplinger	PROPN
admet-529	579	7	,	,	PUNCT
admet-529	579	8	p.	p.	NOUN
admet-529	579	9	m.	m.	NOUN
admet-529	579	10	;	;	PUNCT
admet-529	579	11	rego	rego	NOUN
admet-529	579	12	,	,	PUNCT
admet-529	579	13	m.	m.	NOUN
admet-529	579	14	j.	j.	PROPN
admet-529	579	15	;	;	PUNCT
admet-529	579	16	rouse	rouse	VERB
admet-529	579	17	,	,	PUNCT
admet-529	579	18	e.	e.	PROPN
admet-529	579	19	s.	s.	PROPN
admet-529	579	20	.	.	PUNCT
admet-529	580	1	epsa	epsa	PROPN
admet-529	580	2	:	:	PUNCT
admet-529	580	3	a	a	DET
admet-529	580	4	new	new	ADJ
admet-529	580	5	bioavailability	bioavailability	NOUN
admet-529	580	6	/	/	SYM
admet-529	580	7	permeability	permeability	NOUN
admet-529	580	8	assay	assay	VERB
admet-529	580	9	.	.	PUNCT
admet-529	581	1	in	in	ADP
admet-529	581	2	:	:	PUNCT
admet-529	581	3	http://www.avericadiscovery.com/blog/epsa/	http://www.avericadiscovery.com/blog/epsa/	PROPN
admet-529	581	4	(	(	PUNCT
admet-529	581	5	ed	ed	NOUN
admet-529	581	6	.	.	PUNCT
admet-529	581	7	)	)	PUNCT
admet-529	581	8	,	,	PUNCT
admet-529	581	9	2015	2015	NUM
admet-529	581	10	.	.	PUNCT
admet-529	582	1	http://www.avericadiscovery.com/blog/epsa/	http://www.avericadiscovery.com/blog/epsa/	PROPN
admet-529	582	2	g.h	g.h	PROPN
admet-529	582	3	.	.	PROPN
admet-529	583	1	goetz	goetz	PROPN
admet-529	583	2	and	and	CCONJ
admet-529	583	3	m.	m.	NOUN
admet-529	583	4	shalaeva	shalaeva	PROPN
admet-529	583	5	admet	admet	PROPN
admet-529	583	6	&	&	CCONJ
admet-529	583	7	dmpk	dmpk	PROPN
admet-529	583	8	6(2	6(2	NUM
admet-529	583	9	)	)	PUNCT
admet-529	583	10	(	(	PUNCT
admet-529	583	11	2018	2018	NUM
admet-529	583	12	)	)	PUNCT
admet-529	583	13	85	85	NUM
admet-529	583	14	-	-	SYM
admet-529	583	15	104	104	NUM
admet-529	583	16	104	104	NUM
admet-529	584	1	[	[	X
admet-529	584	2	98	98	NUM
admet-529	584	3	]	]	PUNCT
admet-529	584	4	p.	p.	NOUN
admet-529	584	5	wipf	wipf	PROPN
admet-529	584	6	.	.	PUNCT
admet-529	585	1	acs	acs	PROPN
admet-529	585	2	medicinal	medicinal	ADJ
admet-529	585	3	chemistry	chemistry	NOUN
admet-529	585	4	letters	letter	NOUN
admet-529	585	5	:	:	PUNCT
admet-529	585	6	technology	technology	NOUN
admet-529	585	7	notes	note	VERB
admet-529	585	8	.	.	PUNCT
admet-529	586	1	acs	acs	PROPN
admet-529	586	2	medicinal	medicinal	ADJ
admet-529	586	3	chemistry	chemistry	NOUN
admet-529	586	4	letters	letter	NOUN
admet-529	586	5	8	8	NUM
admet-529	586	6	(	(	PUNCT
admet-529	586	7	2017	2017	NUM
admet-529	586	8	)	)	PUNCT
admet-529	586	9	1	1	NUM
admet-529	586	10	-	-	SYM
admet-529	586	11	2	2	NUM
admet-529	586	12	.	.	PUNCT
admet-529	587	1	©	©	SYM
admet-529	587	2	2018	2018	NUM
admet-529	587	3	by	by	ADP
admet-529	587	4	the	the	DET
admet-529	587	5	authors	author	NOUN
admet-529	587	6	;	;	PUNCT
admet-529	588	1	licensee	licensee	PROPN
admet-529	588	2	iapc	iapc	PROPN
admet-529	588	3	,	,	PUNCT
admet-529	588	4	zagreb	zagreb	PROPN
admet-529	588	5	,	,	PUNCT
admet-529	588	6	croatia	croatia	PROPN
admet-529	588	7	.	.	PUNCT
admet-529	589	1	this	this	DET
admet-529	589	2	article	article	NOUN
admet-529	589	3	is	be	AUX
admet-529	589	4	an	an	DET
admet-529	589	5	open	open	ADJ
admet-529	589	6	-	-	PUNCT
admet-529	589	7	access	access	NOUN
admet-529	589	8	article	article	NOUN
admet-529	589	9	distributed	distribute	VERB
admet-529	589	10	under	under	ADP
admet-529	589	11	the	the	DET
admet-529	589	12	terms	term	NOUN
admet-529	589	13	and	and	CCONJ
admet-529	589	14	conditions	condition	NOUN
admet-529	589	15	of	of	ADP
admet-529	589	16	the	the	DET
admet-529	589	17	creative	creative	ADJ
admet-529	589	18	commons	common	NOUN
admet-529	589	19	attribution	attribution	NOUN
admet-529	589	20	license	license	NOUN
admet-529	589	21	(	(	PUNCT
admet-529	589	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-529	589	23	)	)	PUNCT
admet-529	589	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN