id	sid	tid	token	lemma	pos
admet-530	1	1	the	the	DET
admet-530	1	2	role	role	NOUN
admet-530	1	3	and	and	CCONJ
admet-530	1	4	impact	impact	NOUN
admet-530	1	5	of	of	ADP
admet-530	1	6	high	high	ADJ
admet-530	1	7	throughput	throughput	NOUN
admet-530	1	8	biomimetic	biomimetic	ADJ
admet-530	1	9	measurements	measurement	NOUN
admet-530	1	10	in	in	ADP
admet-530	1	11	drug	drug	NOUN
admet-530	1	12	discovery	discovery	NOUN
admet-530	1	13	doi	doi	PROPN
admet-530	1	14	:	:	PUNCT
admet-530	1	15	10.5599	10.5599	NUM
admet-530	1	16	/	/	SYM
admet-530	1	17	admet.530	admet.530	VERB
admet-530	1	18	74	74	NUM
admet-530	1	19	admet	admet	NOUN
admet-530	1	20	&	&	CCONJ
admet-530	1	21	dmpk	dmpk	PROPN
admet-530	1	22	6(2	6(2	NUM
admet-530	1	23	)	)	PUNCT
admet-530	1	24	(	(	PUNCT
admet-530	1	25	2018	2018	NUM
admet-530	1	26	)	)	PUNCT
admet-530	1	27	74	74	NUM
admet-530	1	28	-	-	SYM
admet-530	1	29	84	84	NUM
admet-530	1	30	;	;	PUNCT
admet-530	1	31	doi	doi	NOUN
admet-530	1	32	:	:	PUNCT
admet-530	1	33	http://dx.doi.org/10.5599/admet.530	http://dx.doi.org/10.5599/admet.530	NOUN
admet-530	1	34	open	open	ADJ
admet-530	1	35	access	access	NOUN
admet-530	1	36	:	:	PUNCT
admet-530	1	37	issn	issn	PROPN
admet-530	1	38	:	:	PUNCT
admet-530	1	39	1848	1848	NUM
admet-530	1	40	-	-	SYM
admet-530	1	41	7718	7718	NUM
admet-530	1	42	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-530	1	43	review	review	VERB
admet-530	1	44	the	the	DET
admet-530	1	45	role	role	NOUN
admet-530	1	46	and	and	CCONJ
admet-530	1	47	impact	impact	NOUN
admet-530	1	48	of	of	ADP
admet-530	1	49	high	high	ADJ
admet-530	1	50	throughput	throughput	NOUN
admet-530	1	51	biomimetic	biomimetic	ADJ
admet-530	1	52	measurements	measurement	NOUN
admet-530	1	53	in	in	ADP
admet-530	1	54	drug	drug	NOUN
admet-530	1	55	discovery	discovery	NOUN
admet-530	1	56	shenaz	shenaz	VERB
admet-530	1	57	bunally	bunally	ADV
admet-530	1	58	*	*	PUNCT
admet-530	1	59	and	and	CCONJ
admet-530	1	60	robert	robert	PROPN
admet-530	1	61	j.	j.	PROPN
admet-530	1	62	young	young	PROPN
admet-530	1	63	*	*	PROPN
admet-530	1	64	drug	drug	NOUN
admet-530	1	65	design	design	NOUN
admet-530	1	66	&	&	CCONJ
admet-530	1	67	selection	selection	NOUN
admet-530	1	68	,	,	PUNCT
admet-530	1	69	glaxosmithkline	glaxosmithkline	PROPN
admet-530	1	70	medicines	medicines	PROPN
admet-530	1	71	research	research	NOUN
admet-530	1	72	centre	centre	NOUN
admet-530	1	73	,	,	PUNCT
admet-530	1	74	stevenage	stevenage	PROPN
admet-530	1	75	,	,	PUNCT
admet-530	1	76	sg1	sg1	PROPN
admet-530	1	77	2ny	2ny	ADJ
admet-530	1	78	,	,	PUNCT
admet-530	1	79	uk	uk	PROPN
admet-530	1	80	.	.	PROPN
admet-530	1	81	*	*	PUNCT
admet-530	1	82	corresponding	correspond	VERB
admet-530	1	83	authors	author	NOUN
admet-530	1	84	e	e	NOUN
admet-530	1	85	-	-	NOUN
admet-530	1	86	mail	mail	NOUN
admet-530	1	87	:	:	PUNCT
admet-530	1	88	shenaz.b.bunally@gsk.com	shenaz.b.bunally@gsk.com	PROPN
admet-530	1	89	,	,	PUNCT
admet-530	1	90	rob.j.young@gsk.com	rob.j.young@gsk.com	PROPN
admet-530	1	91	;	;	PUNCT
admet-530	1	92	tel	tel	PROPN
admet-530	1	93	.	.	PUNCT
admet-530	1	94	:	:	PUNCT
admet-530	2	1	+44	+44	PROPN
admet-530	2	2	1738	1738	NUM
admet-530	2	3	551372	551372	NUM
admet-530	2	4	received	receive	VERB
admet-530	2	5	:	:	PUNCT
admet-530	2	6	march	march	PROPN
admet-530	2	7	29	29	NUM
admet-530	2	8	,	,	PUNCT
admet-530	2	9	2018	2018	NUM
admet-530	2	10	;	;	PUNCT
admet-530	2	11	revised	revise	VERB
admet-530	2	12	:	:	PUNCT
admet-530	2	13	may	may	AUX
admet-530	2	14	16	16	NUM
admet-530	2	15	,	,	PUNCT
admet-530	2	16	2018	2018	NUM
admet-530	2	17	;	;	PUNCT
admet-530	2	18	available	available	ADJ
admet-530	2	19	online	online	ADV
admet-530	2	20	:	:	PUNCT
admet-530	2	21	may	may	AUX
admet-530	2	22	25	25	NUM
admet-530	2	23	,	,	PUNCT
admet-530	2	24	2018	2018	NUM
admet-530	2	25	abstract	abstract	NOUN
admet-530	2	26	during	during	ADP
admet-530	2	27	the	the	DET
admet-530	2	28	early	early	ADJ
admet-530	2	29	phase	phase	NOUN
admet-530	2	30	of	of	ADP
admet-530	2	31	drug	drug	NOUN
admet-530	2	32	discovery	discovery	NOUN
admet-530	2	33	,	,	PUNCT
admet-530	2	34	it	it	PRON
admet-530	2	35	is	be	AUX
admet-530	2	36	becoming	become	VERB
admet-530	2	37	increasingly	increasingly	ADV
admet-530	2	38	important	important	ADJ
admet-530	2	39	to	to	PART
admet-530	2	40	acquire	acquire	VERB
admet-530	2	41	the	the	DET
admet-530	2	42	full	full	ADJ
admet-530	2	43	physicochemical	physicochemical	ADJ
admet-530	2	44	profile	profile	NOUN
admet-530	2	45	of	of	ADP
admet-530	2	46	molecules	molecule	NOUN
admet-530	2	47	.	.	PUNCT
admet-530	3	1	for	for	ADP
admet-530	3	2	this	this	DET
admet-530	3	3	purpose	purpose	NOUN
admet-530	3	4	,	,	PUNCT
admet-530	3	5	there	there	PRON
admet-530	3	6	is	be	VERB
admet-530	3	7	a	a	DET
admet-530	3	8	strong	strong	ADJ
admet-530	3	9	interest	interest	NOUN
admet-530	3	10	in	in	ADP
admet-530	3	11	developing	develop	VERB
admet-530	3	12	efficient	efficient	ADJ
admet-530	3	13	and	and	CCONJ
admet-530	3	14	cost	cost	NOUN
admet-530	3	15	-	-	PUNCT
admet-530	3	16	effective	effective	ADJ
admet-530	3	17	platforms	platform	NOUN
admet-530	3	18	for	for	ADP
admet-530	3	19	fast	fast	ADJ
admet-530	3	20	and	and	CCONJ
admet-530	3	21	reliable	reliable	ADJ
admet-530	3	22	measurements	measurement	NOUN
admet-530	3	23	of	of	ADP
admet-530	3	24	physicochemical	physicochemical	ADJ
admet-530	3	25	properties	property	NOUN
admet-530	3	26	.	.	PUNCT
admet-530	4	1	we	we	PRON
admet-530	4	2	have	have	AUX
admet-530	4	3	developed	develop	VERB
admet-530	4	4	an	an	DET
admet-530	4	5	automated	automate	VERB
admet-530	4	6	physchem	physchem	NOUN
admet-530	4	7	platform	platform	NOUN
admet-530	4	8	which	which	PRON
admet-530	4	9	ensures	ensure	VERB
admet-530	4	10	that	that	SCONJ
admet-530	4	11	consistent	consistent	ADJ
admet-530	4	12	,	,	PUNCT
admet-530	4	13	comprehensive	comprehensive	ADJ
admet-530	4	14	,	,	PUNCT
admet-530	4	15	and	and	CCONJ
admet-530	4	16	highquality	highquality	NOUN
admet-530	4	17	physicochemical	physicochemical	ADJ
admet-530	4	18	property	property	NOUN
admet-530	4	19	measurements	measurement	NOUN
admet-530	4	20	and	and	CCONJ
admet-530	4	21	derived	derive	VERB
admet-530	4	22	property	property	NOUN
admet-530	4	23	information	information	NOUN
admet-530	4	24	for	for	ADP
admet-530	4	25	100	100	NUM
admet-530	4	26	's	'	NOUN
admet-530	4	27	of	of	ADP
admet-530	4	28	compounds	compound	NOUN
admet-530	4	29	per	per	ADP
admet-530	4	30	week	week	NOUN
admet-530	4	31	are	be	AUX
admet-530	4	32	available	available	ADJ
admet-530	4	33	alongside	alongside	ADP
admet-530	4	34	potency	potency	NOUN
admet-530	4	35	data	datum	NOUN
admet-530	4	36	at	at	ADP
admet-530	4	37	the	the	DET
admet-530	4	38	right	right	ADJ
admet-530	4	39	time	time	NOUN
admet-530	4	40	to	to	PART
admet-530	4	41	guide	guide	VERB
admet-530	4	42	compound	compound	NOUN
admet-530	4	43	progression	progression	NOUN
admet-530	4	44	decisions	decision	NOUN
admet-530	4	45	.	.	PUNCT
admet-530	5	1	we	we	PRON
admet-530	5	2	discuss	discuss	VERB
admet-530	5	3	the	the	DET
admet-530	5	4	routine	routine	ADJ
admet-530	5	5	assessments	assessment	NOUN
admet-530	5	6	of	of	ADP
admet-530	5	7	biomimetic	biomimetic	ADJ
admet-530	5	8	properties	property	NOUN
admet-530	5	9	using	use	VERB
admet-530	5	10	high	high	ADJ
admet-530	5	11	throughput	throughput	NOUN
admet-530	5	12	automated	automate	VERB
admet-530	5	13	highperformance	highperformance	NOUN
admet-530	5	14	liquid	liquid	NOUN
admet-530	5	15	chromatography	chromatography	NOUN
admet-530	5	16	(	(	PUNCT
admet-530	5	17	hplc	hplc	NOUN
admet-530	5	18	)	)	PUNCT
admet-530	5	19	platforms	platform	NOUN
admet-530	5	20	,	,	PUNCT
admet-530	5	21	with	with	ADP
admet-530	5	22	details	detail	NOUN
admet-530	5	23	of	of	ADP
admet-530	5	24	the	the	DET
admet-530	5	25	methods	method	NOUN
admet-530	5	26	and	and	CCONJ
admet-530	5	27	hardware	hardware	NOUN
admet-530	5	28	employed	employ	VERB
admet-530	5	29	,	,	PUNCT
admet-530	5	30	also	also	ADV
admet-530	5	31	with	with	ADP
admet-530	5	32	illustrations	illustration	NOUN
admet-530	5	33	of	of	ADP
admet-530	5	34	the	the	DET
admet-530	5	35	quality	quality	NOUN
admet-530	5	36	and	and	CCONJ
admet-530	5	37	impact	impact	NOUN
admet-530	5	38	of	of	ADP
admet-530	5	39	the	the	DET
admet-530	5	40	data	datum	NOUN
admet-530	5	41	generated	generate	VERB
admet-530	5	42	.	.	PUNCT
admet-530	6	1	keywords	keyword	NOUN
admet-530	6	2	lipophilicity	lipophilicity	NOUN
admet-530	6	3	;	;	PUNCT
admet-530	6	4	physicochemical	physicochemical	ADJ
admet-530	6	5	properties	property	NOUN
admet-530	6	6	;	;	PUNCT
admet-530	6	7	biomimetic	biomimetic	ADJ
admet-530	6	8	chromatography	chromatography	NOUN
admet-530	6	9	,	,	PUNCT
admet-530	6	10	drug	drug	NOUN
admet-530	6	11	efficiency	efficiency	NOUN
admet-530	6	12	;	;	PUNCT
admet-530	6	13	candidate	candidate	NOUN
admet-530	6	14	quality	quality	NOUN
admet-530	6	15	introduction	introduction	NOUN
admet-530	6	16	the	the	DET
admet-530	6	17	use	use	NOUN
admet-530	6	18	of	of	ADP
admet-530	6	19	biomimetic	biomimetic	ADJ
admet-530	6	20	/	/	SYM
admet-530	6	21	physicochemical	physicochemical	ADJ
admet-530	6	22	measurements	measurement	NOUN
admet-530	6	23	,	,	PUNCT
admet-530	6	24	such	such	ADJ
admet-530	6	25	as	as	ADP
admet-530	6	26	lipophilicity	lipophilicity	NOUN
admet-530	6	27	and	and	CCONJ
admet-530	6	28	protein	protein	NOUN
admet-530	6	29	/	/	SYM
admet-530	6	30	artificial	artificial	ADJ
admet-530	6	31	membrane	membrane	NOUN
admet-530	6	32	binding	bind	VERB
admet-530	6	33	,	,	PUNCT
admet-530	6	34	to	to	PART
admet-530	6	35	help	help	VERB
admet-530	6	36	rationalise	rationalise	VERB
admet-530	6	37	the	the	DET
admet-530	6	38	behaviour	behaviour	NOUN
admet-530	6	39	of	of	ADP
admet-530	6	40	experimental	experimental	ADJ
admet-530	6	41	molecules	molecule	NOUN
admet-530	6	42	in	in	ADP
admet-530	6	43	biological	biological	ADJ
admet-530	6	44	environments	environment	NOUN
admet-530	6	45	is	be	AUX
admet-530	6	46	an	an	DET
admet-530	6	47	important	important	ADJ
admet-530	6	48	facet	facet	NOUN
admet-530	6	49	of	of	ADP
admet-530	6	50	modern	modern	ADJ
admet-530	6	51	drug	drug	NOUN
admet-530	6	52	discovery	discovery	NOUN
admet-530	6	53	[	[	X
admet-530	6	54	1,2	1,2	NUM
admet-530	6	55	]	]	PUNCT
admet-530	6	56	.	.	PUNCT
admet-530	7	1	such	such	ADJ
admet-530	7	2	measurements	measurement	NOUN
admet-530	7	3	can	can	AUX
admet-530	7	4	be	be	AUX
admet-530	7	5	used	use	VERB
admet-530	7	6	not	not	PART
admet-530	7	7	only	only	ADV
admet-530	7	8	as	as	ADP
admet-530	7	9	surrogates	surrogate	NOUN
admet-530	7	10	to	to	ADP
admet-530	7	11	model	model	NOUN
admet-530	7	12	and	and	CCONJ
admet-530	7	13	predict	predict	VERB
admet-530	7	14	behaviour	behaviour	NOUN
admet-530	7	15	,	,	PUNCT
admet-530	7	16	but	but	CCONJ
admet-530	7	17	also	also	ADV
admet-530	7	18	to	to	PART
admet-530	7	19	estimate	estimate	VERB
admet-530	7	20	the	the	DET
admet-530	7	21	quality	quality	NOUN
admet-530	7	22	of	of	ADP
admet-530	7	23	a	a	DET
admet-530	7	24	given	give	VERB
admet-530	7	25	molecule	molecule	NOUN
admet-530	7	26	and	and	CCONJ
admet-530	7	27	thus	thus	ADV
admet-530	7	28	its	its	PRON
admet-530	7	29	chances	chance	NOUN
admet-530	7	30	of	of	ADP
admet-530	7	31	progression	progression	NOUN
admet-530	7	32	[	[	X
admet-530	7	33	2,3	2,3	NUM
admet-530	7	34	]	]	PUNCT
admet-530	7	35	;	;	PUNCT
admet-530	7	36	indeed	indeed	ADV
admet-530	7	37	,	,	PUNCT
admet-530	7	38	high	high	ADJ
admet-530	7	39	clinical	clinical	ADJ
admet-530	7	40	attrition	attrition	NOUN
admet-530	7	41	rates	rate	NOUN
admet-530	7	42	have	have	AUX
admet-530	7	43	been	be	AUX
admet-530	7	44	attributed	attribute	VERB
admet-530	7	45	to	to	ADP
admet-530	7	46	sub	sub	ADJ
admet-530	7	47	-	-	ADJ
admet-530	7	48	optimal	optimal	ADJ
admet-530	7	49	physicochemical	physicochemical	ADJ
admet-530	7	50	properties	property	NOUN
admet-530	7	51	[	[	X
admet-530	7	52	4,5	4,5	NUM
admet-530	7	53	]	]	PUNCT
admet-530	7	54	.	.	PUNCT
admet-530	8	1	high	high	ADJ
admet-530	8	2	quality	quality	NOUN
admet-530	8	3	,	,	PUNCT
admet-530	8	4	high	high	ADJ
admet-530	8	5	throughput	throughput	NOUN
admet-530	8	6	methods	method	NOUN
admet-530	8	7	for	for	ADP
admet-530	8	8	biomimetic	biomimetic	ADJ
admet-530	8	9	measurements	measurement	NOUN
admet-530	8	10	are	be	AUX
admet-530	8	11	key	key	ADJ
admet-530	8	12	elements	element	NOUN
admet-530	8	13	of	of	ADP
admet-530	8	14	these	these	DET
admet-530	8	15	approaches	approach	NOUN
admet-530	8	16	.	.	PUNCT
admet-530	9	1	the	the	DET
admet-530	9	2	partitioning	partitioning	NOUN
admet-530	9	3	and	and	CCONJ
admet-530	9	4	distribution	distribution	NOUN
admet-530	9	5	of	of	ADP
admet-530	9	6	drug	drug	NOUN
admet-530	9	7	molecules	molecule	NOUN
admet-530	9	8	between	between	ADP
admet-530	9	9	bio	bio	NOUN
admet-530	9	10	-	-	NOUN
admet-530	9	11	phases	phase	NOUN
admet-530	9	12	are	be	AUX
admet-530	9	13	fundamental	fundamental	ADJ
admet-530	9	14	to	to	ADP
admet-530	9	15	drug	drug	NOUN
admet-530	9	16	action	action	NOUN
admet-530	9	17	[	[	X
admet-530	9	18	6	6	NUM
admet-530	9	19	]	]	PUNCT
admet-530	9	20	,	,	PUNCT
admet-530	9	21	modelling	modelling	NOUN
admet-530	9	22	and	and	CCONJ
admet-530	9	23	understanding	understand	VERB
admet-530	9	24	these	these	DET
admet-530	9	25	processes	process	NOUN
admet-530	9	26	provides	provide	VERB
admet-530	9	27	insight	insight	NOUN
admet-530	9	28	into	into	ADP
admet-530	9	29	absorption	absorption	NOUN
admet-530	9	30	,	,	PUNCT
admet-530	9	31	distribution	distribution	NOUN
admet-530	9	32	,	,	PUNCT
admet-530	9	33	metabolism	metabolism	NOUN
admet-530	9	34	and	and	CCONJ
admet-530	9	35	excretion	excretion	NOUN
admet-530	9	36	,	,	PUNCT
admet-530	9	37	adme	adme	VERB
admet-530	10	1	[	[	X
admet-530	10	2	6	6	NUM
admet-530	10	3	]	]	PUNCT
admet-530	10	4	,	,	PUNCT
admet-530	10	5	the	the	DET
admet-530	10	6	key	key	ADJ
admet-530	10	7	elements	element	NOUN
admet-530	10	8	of	of	ADP
admet-530	10	9	pharmacokinetics	pharmacokinetic	NOUN
admet-530	10	10	,	,	PUNCT
admet-530	10	11	the	the	DET
admet-530	10	12	science	science	NOUN
admet-530	10	13	of	of	ADP
admet-530	10	14	what	what	PRON
admet-530	10	15	the	the	DET
admet-530	10	16	body	body	NOUN
admet-530	10	17	does	do	AUX
admet-530	10	18	to	to	ADP
admet-530	10	19	a	a	DET
admet-530	10	20	drug	drug	NOUN
admet-530	10	21	.	.	PUNCT
admet-530	11	1	the	the	DET
admet-530	11	2	partition	partition	NOUN
admet-530	11	3	and	and	CCONJ
admet-530	11	4	distribution	distribution	NOUN
admet-530	11	5	coefficients	coefficient	NOUN
admet-530	11	6	of	of	ADP
admet-530	11	7	drug	drug	NOUN
admet-530	11	8	molecules	molecule	NOUN
admet-530	11	9	between	between	ADP
admet-530	11	10	1	1	NUM
admet-530	11	11	-	-	PUNCT
admet-530	11	12	octanol	octanol	NOUN
admet-530	11	13	and	and	CCONJ
admet-530	11	14	aqueous	aqueous	ADJ
admet-530	11	15	buffers	buffer	NOUN
admet-530	11	16	(	(	PUNCT
admet-530	11	17	ow	ow	INTJ
admet-530	11	18	)	)	PUNCT
admet-530	11	19	are	be	AUX
admet-530	11	20	well	well	ADV
admet-530	11	21	-	-	PUNCT
admet-530	11	22	established	establish	VERB
admet-530	11	23	standards	standard	NOUN
admet-530	11	24	,	,	PUNCT
admet-530	11	25	and	and	CCONJ
admet-530	11	26	these	these	DET
admet-530	11	27	biomimetic	biomimetic	ADJ
admet-530	11	28	estimates	estimate	NOUN
admet-530	11	29	of	of	ADP
admet-530	11	30	lipophilicity	lipophilicity	PROPN
admet-530	11	31	/	/	SYM
admet-530	11	32	hydrophobicity	hydrophobicity	NOUN
admet-530	11	33	demonstrably	demonstrably	ADV
admet-530	11	34	influence	influence	NOUN
admet-530	11	35	adme	adme	NOUN
admet-530	11	36	profiles	profile	NOUN
admet-530	11	37	and	and	CCONJ
admet-530	11	38	other	other	ADJ
admet-530	11	39	outcomes	outcome	NOUN
admet-530	11	40	.	.	PUNCT
admet-530	12	1	the	the	DET
admet-530	12	2	negative	negative	ADJ
admet-530	12	3	impact	impact	NOUN
admet-530	12	4	of	of	ADP
admet-530	12	5	excessive	excessive	ADJ
admet-530	12	6	lipophilicity	lipophilicity	NOUN
admet-530	12	7	on	on	ADP
admet-530	12	8	the	the	DET
admet-530	12	9	chances	chance	NOUN
admet-530	12	10	of	of	ADP
admet-530	12	11	progression	progression	NOUN
admet-530	12	12	of	of	ADP
admet-530	12	13	experimental	experimental	ADJ
admet-530	12	14	molecules	molecule	NOUN
admet-530	12	15	has	have	AUX
admet-530	12	16	come	come	VERB
admet-530	12	17	under	under	ADP
admet-530	12	18	particular	particular	ADJ
admet-530	12	19	scrutiny	scrutiny	NOUN
admet-530	12	20	over	over	ADP
admet-530	12	21	the	the	DET
admet-530	12	22	past	past	ADJ
admet-530	12	23	decade	decade	NOUN
admet-530	12	24	and	and	CCONJ
admet-530	12	25	changed	change	VERB
admet-530	12	26	practices	practice	NOUN
admet-530	12	27	in	in	ADP
admet-530	12	28	drug	drug	NOUN
admet-530	12	29	discovery	discovery	NOUN
admet-530	12	30	are	be	AUX
admet-530	12	31	evident	evident	ADJ
admet-530	12	32	by	by	ADP
admet-530	12	33	recent	recent	ADJ
admet-530	12	34	improvements	improvement	NOUN
admet-530	12	35	in	in	ADP
admet-530	12	36	the	the	DET
admet-530	12	37	physicochemical	physicochemical	ADJ
admet-530	12	38	quality	quality	NOUN
admet-530	12	39	of	of	ADP
admet-530	12	40	molecules	molecule	NOUN
admet-530	12	41	[	[	X
admet-530	12	42	7	7	NUM
admet-530	12	43	]	]	PUNCT
admet-530	12	44	.	.	PUNCT
admet-530	13	1	lipophilicity	lipophilicity	NOUN
admet-530	13	2	measurements	measurement	NOUN
admet-530	13	3	(	(	PUNCT
admet-530	13	4	such	such	ADJ
admet-530	13	5	as	as	ADP
admet-530	13	6	log10	log10	PROPN
admet-530	13	7	[	[	PUNCT
admet-530	13	8	ow	ow	INTJ
admet-530	13	9	-	-	PUNCT
admet-530	13	10	partition	partition	NOUN
admet-530	13	11	]	]	PUNCT
admet-530	13	12	,	,	PUNCT
admet-530	13	13	log	log	VERB
admet-530	13	14	p	p	NOUN
admet-530	13	15	or	or	CCONJ
admet-530	13	16	the	the	DET
admet-530	13	17	distribution	distribution	NOUN
admet-530	13	18	at	at	ADP
admet-530	13	19	a	a	DET
admet-530	13	20	given	give	VERB
admet-530	13	21	ph	ph	VERB
admet-530	13	22	,	,	PUNCT
admet-530	13	23	log	log	NOUN
admet-530	13	24	dph	dph	NOUN
admet-530	13	25	)	)	PUNCT
admet-530	13	26	are	be	AUX
admet-530	13	27	demonstrably	demonstrably	ADV
admet-530	13	28	unreliable	unreliable	ADJ
admet-530	13	29	for	for	ADP
admet-530	13	30	poorly	poorly	ADJ
admet-530	13	31	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-530	13	32	mailto:shenaz.b.bunally@gsk.com	mailto:shenaz.b.bunally@gsk.com	PROPN
admet-530	13	33	mailto:rob.j.young@gsk.com	mailto:rob.j.young@gsk.com	PROPN
admet-530	13	34	admet	admet	PROPN
admet-530	13	35	&	&	CCONJ
admet-530	13	36	dmpk	dmpk	PROPN
admet-530	13	37	6(2	6(2	NUM
admet-530	13	38	)	)	PUNCT
admet-530	13	39	(	(	PUNCT
admet-530	13	40	2018	2018	NUM
admet-530	13	41	)	)	PUNCT
admet-530	13	42	74	74	NUM
admet-530	13	43	-	-	SYM
admet-530	13	44	84	84	NUM
admet-530	13	45	high	high	ADJ
admet-530	13	46	throughput	throughput	NOUN
admet-530	13	47	biomimetic	biomimetic	ADJ
admet-530	13	48	measurements	measurement	NOUN
admet-530	13	49	in	in	ADP
admet-530	13	50	drug	drug	NOUN
admet-530	13	51	discovery	discovery	NOUN
admet-530	13	52	doi	doi	PROPN
admet-530	13	53	:	:	PUNCT
admet-530	13	54	10.5599	10.5599	NUM
admet-530	13	55	/	/	SYM
admet-530	13	56	admet.530	admet.530	VERB
admet-530	13	57	75	75	NUM
admet-530	13	58	soluble	soluble	ADJ
admet-530	13	59	compounds	compound	NOUN
admet-530	13	60	[	[	X
admet-530	13	61	8	8	NUM
admet-530	13	62	]	]	PUNCT
admet-530	13	63	.	.	PUNCT
admet-530	14	1	however	however	ADV
admet-530	14	2	,	,	PUNCT
admet-530	14	3	fast	fast	ADJ
admet-530	14	4	gradient	gradient	NOUN
admet-530	14	5	reversed	reverse	VERB
admet-530	14	6	phase	phase	NOUN
admet-530	14	7	high	high	ADJ
admet-530	14	8	pressure	pressure	NOUN
admet-530	14	9	liquid	liquid	NOUN
admet-530	14	10	chromatographic	chromatographic	ADJ
admet-530	14	11	(	(	PUNCT
admet-530	14	12	hplc	hplc	NOUN
admet-530	14	13	)	)	PUNCT
admet-530	14	14	methodologies	methodology	NOUN
admet-530	14	15	using	use	VERB
admet-530	14	16	c-18	c-18	PROPN
admet-530	14	17	columns	column	NOUN
admet-530	14	18	provide	provide	VERB
admet-530	14	19	an	an	DET
admet-530	14	20	effective	effective	ADJ
admet-530	14	21	and	and	CCONJ
admet-530	14	22	reliable	reliable	ADJ
admet-530	14	23	replacement	replacement	NOUN
admet-530	15	1	[	[	X
admet-530	15	2	9	9	NUM
admet-530	15	3	]	]	PUNCT
admet-530	15	4	,	,	PUNCT
admet-530	15	5	irrespective	irrespective	ADV
admet-530	15	6	of	of	ADP
admet-530	15	7	solubility	solubility	NOUN
admet-530	15	8	[	[	X
admet-530	15	9	10	10	NUM
admet-530	15	10	]	]	PUNCT
admet-530	15	11	.	.	PUNCT
admet-530	16	1	analyses	analysis	NOUN
admet-530	16	2	of	of	ADP
admet-530	16	3	data	datum	NOUN
admet-530	16	4	generated	generate	VERB
admet-530	16	5	in	in	ADP
admet-530	16	6	this	this	DET
admet-530	16	7	manner	manner	NOUN
admet-530	16	8	gave	give	VERB
admet-530	16	9	an	an	DET
admet-530	16	10	improved	improved	ADJ
admet-530	16	11	resolution	resolution	NOUN
admet-530	16	12	of	of	ADP
admet-530	16	13	adme	adme	NOUN
admet-530	16	14	outcomes	outcome	NOUN
admet-530	16	15	;	;	PUNCT
admet-530	16	16	together	together	ADV
admet-530	16	17	with	with	ADP
admet-530	16	18	enhanced	enhanced	ADJ
admet-530	16	19	log	log	NOUN
admet-530	16	20	p	p	X
admet-530	16	21	/	/	SYM
admet-530	16	22	log	log	NOUN
admet-530	16	23	d	d	NOUN
admet-530	16	24	predictions	prediction	NOUN
admet-530	16	25	that	that	PRON
admet-530	16	26	have	have	AUX
admet-530	16	27	enabled	enable	VERB
admet-530	16	28	the	the	DET
admet-530	16	29	construction	construction	NOUN
admet-530	16	30	of	of	ADP
admet-530	16	31	better	well	ADJ
admet-530	16	32	structurebased	structurebase	VERB
admet-530	16	33	in	in	ADP
admet-530	16	34	silico	silico	NOUN
admet-530	16	35	predictive	predictive	ADJ
admet-530	16	36	models	model	NOUN
admet-530	16	37	.	.	PUNCT
admet-530	17	1	other	other	ADJ
admet-530	17	2	non	non	ADJ
admet-530	17	3	-	-	NOUN
admet-530	17	4	silica	silica	ADJ
admet-530	17	5	based	base	VERB
admet-530	17	6	polymeric	polymeric	ADJ
admet-530	17	7	stationary	stationary	ADJ
admet-530	17	8	phases	phase	NOUN
admet-530	17	9	are	be	AUX
admet-530	17	10	being	be	AUX
admet-530	17	11	investigated	investigate	VERB
admet-530	17	12	to	to	PART
admet-530	17	13	provide	provide	VERB
admet-530	17	14	insight	insight	NOUN
admet-530	17	15	into	into	ADP
admet-530	17	16	non	non	ADJ
admet-530	17	17	-	-	ADJ
admet-530	17	18	polar	polar	ADJ
admet-530	17	19	environments	environment	NOUN
admet-530	17	20	and	and	CCONJ
admet-530	17	21	the	the	DET
admet-530	17	22	potential	potential	NOUN
admet-530	17	23	for	for	ADP
admet-530	17	24	intramolecular	intramolecular	ADJ
admet-530	17	25	hydrogen	hydrogen	NOUN
admet-530	17	26	bonding	bonding	NOUN
admet-530	17	27	[	[	X
admet-530	17	28	11	11	NUM
admet-530	17	29	]	]	PUNCT
admet-530	17	30	.	.	PUNCT
admet-530	18	1	the	the	DET
admet-530	18	2	grafting	grafting	NOUN
admet-530	18	3	of	of	ADP
admet-530	18	4	stationary	stationary	ADJ
admet-530	18	5	phases	phase	NOUN
admet-530	18	6	other	other	ADJ
admet-530	18	7	than	than	ADP
admet-530	18	8	c-18	c-18	PROPN
admet-530	18	9	,	,	PUNCT
admet-530	18	10	onto	onto	ADP
admet-530	18	11	hplc	hplc	NOUN
admet-530	18	12	columns	column	NOUN
admet-530	18	13	,	,	PUNCT
admet-530	18	14	enables	enable	VERB
admet-530	18	15	the	the	DET
admet-530	18	16	high	high	ADJ
admet-530	18	17	throughput	throughput	NOUN
admet-530	18	18	assessment	assessment	NOUN
admet-530	18	19	of	of	ADP
admet-530	18	20	additional	additional	ADJ
admet-530	18	21	pertinent	pertinent	ADJ
admet-530	18	22	adme	adme	NOUN
admet-530	18	23	interactions	interaction	NOUN
admet-530	18	24	[	[	X
admet-530	18	25	12	12	NUM
admet-530	18	26	]	]	X
admet-530	18	27	,	,	PUNCT
admet-530	18	28	in	in	ADP
admet-530	18	29	particular	particular	ADJ
admet-530	18	30	the	the	DET
admet-530	18	31	plasma	plasma	NOUN
admet-530	18	32	proteins	protein	NOUN
admet-530	18	33	human	human	ADJ
admet-530	18	34	serum	serum	NOUN
admet-530	18	35	albumin	albumin	NOUN
admet-530	18	36	(	(	PUNCT
admet-530	18	37	hsa	hsa	PROPN
admet-530	18	38	)	)	PUNCT
admet-530	18	39	and	and	CCONJ
admet-530	18	40	alpha-1	alpha-1	NOUN
admet-530	18	41	-	-	PUNCT
admet-530	18	42	acid	acid	NOUN
admet-530	18	43	-	-	PUNCT
admet-530	18	44	glycoprotein	glycoprotein	NOUN
admet-530	18	45	(	(	PUNCT
admet-530	18	46	agp	agp	NOUN
admet-530	18	47	)	)	PUNCT
admet-530	18	48	,	,	PUNCT
admet-530	18	49	plus	plus	CCONJ
admet-530	18	50	phosphatidylcholine	phosphatidylcholine	NOUN
admet-530	18	51	,	,	PUNCT
admet-530	18	52	which	which	PRON
admet-530	18	53	acts	act	VERB
admet-530	18	54	as	as	ADP
admet-530	18	55	a	a	DET
admet-530	18	56	surrogate	surrogate	ADJ
admet-530	18	57	immobilised	immobilise	VERB
admet-530	18	58	artificial	artificial	ADJ
admet-530	18	59	membrane	membrane	NOUN
admet-530	18	60	(	(	PUNCT
admet-530	18	61	iam	iam	PROPN
admet-530	18	62	)	)	PUNCT
admet-530	18	63	.	.	PUNCT
admet-530	19	1	the	the	DET
admet-530	19	2	availability	availability	NOUN
admet-530	19	3	of	of	ADP
admet-530	19	4	these	these	DET
admet-530	19	5	various	various	ADJ
admet-530	19	6	biomimetic	biomimetic	ADJ
admet-530	19	7	columns	column	NOUN
admet-530	19	8	within	within	ADP
admet-530	19	9	fully	fully	ADV
admet-530	19	10	automated	automate	VERB
admet-530	19	11	hplc	hplc	NOUN
admet-530	19	12	platforms	platform	NOUN
admet-530	19	13	enables	enable	VERB
admet-530	19	14	the	the	DET
admet-530	19	15	high	high	ADJ
admet-530	19	16	throughput	throughput	NOUN
admet-530	19	17	and	and	CCONJ
admet-530	19	18	cost	cost	NOUN
admet-530	19	19	-	-	PUNCT
admet-530	19	20	effective	effective	ADJ
admet-530	19	21	gathering	gathering	NOUN
admet-530	19	22	of	of	ADP
admet-530	19	23	sets	set	NOUN
admet-530	19	24	of	of	ADP
admet-530	19	25	pertinent	pertinent	ADJ
admet-530	19	26	and	and	CCONJ
admet-530	19	27	reliable	reliable	ADJ
admet-530	19	28	data	datum	NOUN
admet-530	19	29	,	,	PUNCT
admet-530	19	30	which	which	PRON
admet-530	19	31	can	can	AUX
admet-530	19	32	provide	provide	VERB
admet-530	19	33	valuable	valuable	ADJ
admet-530	19	34	insight	insight	NOUN
admet-530	19	35	on	on	ADP
admet-530	19	36	the	the	DET
admet-530	19	37	likely	likely	ADJ
admet-530	19	38	behaviours	behaviour	NOUN
admet-530	19	39	in	in	ADP
admet-530	19	40	biological	biological	ADJ
admet-530	19	41	systems	system	NOUN
admet-530	19	42	.	.	PUNCT
admet-530	20	1	progressing	progress	VERB
admet-530	20	2	compounds	compound	NOUN
admet-530	20	3	with	with	ADP
admet-530	20	4	good	good	ADJ
admet-530	20	5	physicochemical	physicochemical	ADJ
admet-530	20	6	properties	property	NOUN
admet-530	20	7	are	be	AUX
admet-530	20	8	fundamental	fundamental	ADJ
admet-530	20	9	to	to	ADP
admet-530	20	10	pharmaceutical	pharmaceutical	ADJ
admet-530	20	11	companies	company	NOUN
admet-530	20	12	’	’	PART
admet-530	20	13	aspirations	aspiration	NOUN
admet-530	20	14	for	for	ADP
admet-530	20	15	the	the	DET
admet-530	20	16	objective	objective	ADJ
admet-530	20	17	assessment	assessment	NOUN
admet-530	20	18	of	of	ADP
admet-530	20	19	the	the	DET
admet-530	20	20	qualities	quality	NOUN
admet-530	20	21	of	of	ADP
admet-530	20	22	lead	lead	NOUN
admet-530	20	23	and	and	CCONJ
admet-530	20	24	candidate	candidate	NOUN
admet-530	20	25	molecules	molecule	NOUN
admet-530	20	26	[	[	X
admet-530	20	27	13	13	NUM
admet-530	20	28	]	]	PUNCT
admet-530	20	29	.	.	PUNCT
admet-530	21	1	an	an	DET
admet-530	21	2	automated	automate	VERB
admet-530	21	3	platform	platform	NOUN
admet-530	21	4	ensures	ensure	VERB
admet-530	21	5	that	that	SCONJ
admet-530	21	6	consistent	consistent	ADJ
admet-530	21	7	,	,	PUNCT
admet-530	21	8	comprehensive	comprehensive	ADJ
admet-530	21	9	,	,	PUNCT
admet-530	21	10	and	and	CCONJ
admet-530	21	11	high	high	ADJ
admet-530	21	12	-	-	PUNCT
admet-530	21	13	quality	quality	NOUN
admet-530	21	14	physicochemical	physicochemical	ADJ
admet-530	21	15	property	property	NOUN
admet-530	21	16	measurements	measurement	NOUN
admet-530	21	17	and	and	CCONJ
admet-530	21	18	derived	derive	VERB
admet-530	21	19	property	property	NOUN
admet-530	21	20	information	information	NOUN
admet-530	21	21	are	be	AUX
admet-530	21	22	available	available	ADJ
admet-530	21	23	at	at	ADP
admet-530	21	24	the	the	DET
admet-530	21	25	right	right	ADJ
admet-530	21	26	time	time	NOUN
admet-530	21	27	to	to	PART
admet-530	21	28	guide	guide	VERB
admet-530	21	29	compound	compound	NOUN
admet-530	21	30	progression	progression	NOUN
admet-530	21	31	decisions	decision	NOUN
admet-530	21	32	.	.	PUNCT
admet-530	22	1	the	the	DET
admet-530	22	2	role	role	NOUN
admet-530	22	3	and	and	CCONJ
admet-530	22	4	impact	impact	NOUN
admet-530	22	5	of	of	ADP
admet-530	22	6	biomimetic	biomimetic	ADJ
admet-530	22	7	methods	method	NOUN
admet-530	22	8	high	high	ADJ
admet-530	22	9	throughput	throughput	NOUN
admet-530	22	10	workflow	workflow	NOUN
admet-530	22	11	for	for	ADP
admet-530	22	12	hplc	hplc	NOUN
admet-530	22	13	based	base	VERB
admet-530	22	14	assays	assay	NOUN
admet-530	22	15	at	at	ADP
admet-530	22	16	gsk	gsk	NOUN
admet-530	22	17	the	the	DET
admet-530	22	18	physicochemical	physicochemical	ADJ
admet-530	22	19	/	/	SYM
admet-530	22	20	biomimetic	biomimetic	ADJ
admet-530	22	21	assays	assay	NOUN
admet-530	22	22	are	be	AUX
admet-530	22	23	bundled	bundle	VERB
admet-530	22	24	to	to	PART
admet-530	22	25	provide	provide	VERB
admet-530	22	26	kinetic	kinetic	ADJ
admet-530	22	27	solubility	solubility	NOUN
admet-530	23	1	[	[	X
admet-530	23	2	8	8	NUM
admet-530	23	3	]	]	PUNCT
admet-530	23	4	,	,	PUNCT
admet-530	23	5	lipophilicity	lipophilicity	NOUN
admet-530	23	6	and	and	CCONJ
admet-530	23	7	biomimetic	biomimetic	ADJ
admet-530	23	8	binding	bind	VERB
admet-530	23	9	data	datum	NOUN
admet-530	23	10	on	on	ADP
admet-530	23	11	the	the	DET
admet-530	23	12	majority	majority	NOUN
admet-530	23	13	of	of	ADP
admet-530	23	14	project	project	NOUN
admet-530	23	15	compounds	compound	NOUN
admet-530	23	16	during	during	ADP
admet-530	23	17	lead	lead	ADJ
admet-530	23	18	discovery	discovery	NOUN
admet-530	23	19	and	and	CCONJ
admet-530	23	20	optimisation	optimisation	NOUN
admet-530	23	21	.	.	PUNCT
admet-530	24	1	the	the	DET
admet-530	24	2	process	process	NOUN
admet-530	24	3	for	for	ADP
admet-530	24	4	preparing	prepare	VERB
admet-530	24	5	sample	sample	NOUN
admet-530	24	6	plates	plate	NOUN
admet-530	24	7	which	which	PRON
admet-530	24	8	are	be	AUX
admet-530	24	9	“	"	PUNCT
admet-530	24	10	ready	ready	ADJ
admet-530	24	11	to	to	PART
admet-530	24	12	run	run	VERB
admet-530	24	13	”	"	PUNCT
admet-530	24	14	on	on	ADP
admet-530	24	15	the	the	DET
admet-530	24	16	hplc	hplc	NOUN
admet-530	24	17	systems	system	NOUN
admet-530	24	18	is	be	AUX
admet-530	24	19	shown	show	VERB
admet-530	24	20	in	in	ADP
admet-530	24	21	figure	figure	NOUN
admet-530	24	22	1	1	NUM
admet-530	24	23	.	.	PUNCT
admet-530	25	1	at	at	ADP
admet-530	25	2	gsk	gsk	NOUN
admet-530	25	3	all	all	DET
admet-530	25	4	experimental	experimental	ADJ
admet-530	25	5	compounds	compound	NOUN
admet-530	25	6	are	be	AUX
admet-530	25	7	routinely	routinely	ADV
admet-530	25	8	dissolved	dissolve	VERB
admet-530	25	9	and	and	CCONJ
admet-530	25	10	stored	store	VERB
admet-530	25	11	at	at	ADP
admet-530	25	12	10	10	NUM
admet-530	25	13	mm	mm	NOUN
admet-530	25	14	in	in	ADP
admet-530	25	15	dimethyl	dimethyl	PROPN
admet-530	25	16	sulphoxide	sulphoxide	NOUN
admet-530	25	17	(	(	PUNCT
admet-530	25	18	dmso	dmso	ADJ
admet-530	25	19	)	)	PUNCT
admet-530	25	20	solution	solution	NOUN
admet-530	25	21	,	,	PUNCT
admet-530	25	22	for	for	ADP
admet-530	25	23	ease	ease	NOUN
admet-530	25	24	of	of	ADP
admet-530	25	25	automated	automate	VERB
admet-530	25	26	handling	handling	NOUN
admet-530	25	27	.	.	PUNCT
admet-530	26	1	50	50	NUM
admet-530	26	2	l	l	PROPN
admet-530	26	3	samples	sample	NOUN
admet-530	26	4	of	of	ADP
admet-530	26	5	this	this	DET
admet-530	26	6	stock	stock	NOUN
admet-530	26	7	are	be	AUX
admet-530	26	8	dispensed	dispense	VERB
admet-530	26	9	in	in	ADP
admet-530	26	10	96	96	NUM
admet-530	26	11	well	well	ADJ
admet-530	26	12	master	master	NOUN
admet-530	26	13	plates	plate	NOUN
admet-530	26	14	for	for	ADP
admet-530	26	15	the	the	DET
admet-530	26	16	kinetic	kinetic	NOUN
admet-530	26	17	solubility	solubility	NOUN
admet-530	26	18	assay	assay	VERB
admet-530	26	19	,	,	PUNCT
admet-530	26	20	merged	merge	VERB
admet-530	26	21	to	to	PART
admet-530	26	22	give	give	VERB
admet-530	26	23	fully	fully	ADV
admet-530	26	24	populated	populate	VERB
admet-530	26	25	plates	plate	NOUN
admet-530	26	26	.	.	PUNCT
admet-530	27	1	5l	5l	NUM
admet-530	27	2	of	of	ADP
admet-530	27	3	the	the	DET
admet-530	27	4	solutions	solution	NOUN
admet-530	27	5	in	in	ADP
admet-530	27	6	the	the	DET
admet-530	27	7	master	master	NOUN
admet-530	27	8	plates	plate	NOUN
admet-530	27	9	are	be	AUX
admet-530	27	10	dispensed	dispense	VERB
admet-530	27	11	into	into	ADP
admet-530	27	12	daughter	daughter	NOUN
admet-530	27	13	plates	plate	NOUN
admet-530	27	14	;	;	PUNCT
admet-530	27	15	standards	standard	NOUN
admet-530	27	16	and	and	CCONJ
admet-530	27	17	blanks	blank	NOUN
admet-530	27	18	are	be	AUX
admet-530	27	19	added	add	VERB
admet-530	27	20	to	to	ADP
admet-530	27	21	these	these	DET
admet-530	27	22	plates	plate	NOUN
admet-530	27	23	and	and	CCONJ
admet-530	27	24	all	all	DET
admet-530	27	25	the	the	DET
admet-530	27	26	samples	sample	NOUN
admet-530	27	27	are	be	AUX
admet-530	27	28	diluted	dilute	VERB
admet-530	27	29	using	use	VERB
admet-530	27	30	the	the	DET
admet-530	27	31	appropriate	appropriate	ADJ
admet-530	27	32	solvents	solvent	NOUN
admet-530	27	33	such	such	ADJ
admet-530	27	34	as	as	ADP
admet-530	27	35	dmso	dmso	NOUN
admet-530	27	36	and	and	CCONJ
admet-530	27	37	iso	iso	NOUN
admet-530	27	38	-	-	PUNCT
admet-530	27	39	propanol	propanol	NOUN
admet-530	27	40	/	/	SYM
admet-530	27	41	water	water	NOUN
admet-530	27	42	(	(	PUNCT
admet-530	27	43	50/50	50/50	NUM
admet-530	27	44	v	v	NOUN
admet-530	27	45	/	/	SYM
admet-530	27	46	v	v	NOUN
admet-530	27	47	)	)	PUNCT
admet-530	27	48	to	to	PART
admet-530	27	49	produce	produce	VERB
admet-530	27	50	daughter	daughter	NOUN
admet-530	27	51	plates	plate	NOUN
admet-530	27	52	for	for	ADP
admet-530	27	53	the	the	DET
admet-530	27	54	lipophilicity	lipophilicity	NOUN
admet-530	27	55	and	and	CCONJ
admet-530	27	56	biomimetic	biomimetic	ADJ
admet-530	27	57	binding	bind	VERB
admet-530	27	58	assays	assay	NOUN
admet-530	27	59	respectively	respectively	ADV
admet-530	27	60	.	.	PUNCT
admet-530	28	1	each	each	DET
admet-530	28	2	daughter	daughter	NOUN
admet-530	28	3	plate	plate	NOUN
admet-530	28	4	has	have	VERB
admet-530	28	5	a	a	DET
admet-530	28	6	unique	unique	ADJ
admet-530	28	7	barcode	barcode	NOUN
admet-530	28	8	used	use	VERB
admet-530	28	9	to	to	PART
admet-530	28	10	generate	generate	VERB
admet-530	28	11	the	the	DET
admet-530	28	12	plate	plate	NOUN
admet-530	28	13	map	map	NOUN
admet-530	28	14	.	.	PUNCT
admet-530	29	1	to	to	PART
admet-530	29	2	ensure	ensure	VERB
admet-530	29	3	production	production	NOUN
admet-530	29	4	of	of	ADP
admet-530	29	5	data	datum	NOUN
admet-530	29	6	of	of	ADP
admet-530	29	7	high	high	ADJ
admet-530	29	8	quality	quality	NOUN
admet-530	29	9	and	and	CCONJ
admet-530	29	10	integrity	integrity	NOUN
admet-530	29	11	,	,	PUNCT
admet-530	29	12	system	system	NOUN
admet-530	29	13	and	and	CCONJ
admet-530	29	14	assay	assay	NOUN
admet-530	29	15	suitability	suitability	NOUN
admet-530	29	16	checks	check	NOUN
admet-530	29	17	are	be	AUX
admet-530	29	18	embedded	embed	VERB
admet-530	29	19	in	in	ADP
admet-530	29	20	the	the	DET
admet-530	29	21	sample	sample	NOUN
admet-530	29	22	process	process	NOUN
admet-530	29	23	and	and	CCONJ
admet-530	29	24	data	datum	NOUN
admet-530	29	25	analysis	analysis	NOUN
admet-530	29	26	.	.	PUNCT
admet-530	30	1	calibration	calibration	NOUN
admet-530	30	2	data	datum	NOUN
admet-530	30	3	is	be	AUX
admet-530	30	4	monitored	monitor	VERB
admet-530	30	5	before	before	ADV
admet-530	30	6	and	and	CCONJ
admet-530	30	7	after	after	ADP
admet-530	30	8	running	run	VERB
admet-530	30	9	the	the	DET
admet-530	30	10	samples	sample	NOUN
admet-530	30	11	.	.	PUNCT
admet-530	31	1	a	a	DET
admet-530	31	2	set	set	NOUN
admet-530	31	3	of	of	ADP
admet-530	31	4	“	"	PUNCT
admet-530	31	5	check	check	NOUN
admet-530	31	6	”	"	PUNCT
admet-530	31	7	standards	standard	NOUN
admet-530	31	8	with	with	ADP
admet-530	31	9	known	known	ADJ
admet-530	31	10	lipophilicity	lipophilicity	NOUN
admet-530	31	11	and	and	CCONJ
admet-530	31	12	biomimetic	biomimetic	ADJ
admet-530	31	13	binding	bind	VERB
admet-530	31	14	data	datum	NOUN
admet-530	31	15	are	be	AUX
admet-530	31	16	run	run	VERB
admet-530	31	17	during	during	ADP
admet-530	31	18	each	each	DET
admet-530	31	19	sequence	sequence	NOUN
admet-530	31	20	of	of	ADP
admet-530	31	21	samples	sample	NOUN
admet-530	31	22	and	and	CCONJ
admet-530	31	23	the	the	DET
admet-530	31	24	data	datum	NOUN
admet-530	31	25	checked	check	VERB
admet-530	31	26	to	to	PART
admet-530	31	27	ensure	ensure	VERB
admet-530	31	28	they	they	PRON
admet-530	31	29	meet	meet	VERB
admet-530	31	30	the	the	DET
admet-530	31	31	defined	define	VERB
admet-530	31	32	criteria	criterion	NOUN
admet-530	31	33	.	.	PUNCT
admet-530	32	1	an	an	DET
admet-530	32	2	in	in	ADP
admet-530	32	3	-	-	PUNCT
admet-530	32	4	house	house	NOUN
admet-530	32	5	developed	develop	VERB
admet-530	32	6	application	application	NOUN
admet-530	32	7	(	(	PUNCT
admet-530	32	8	figure	figure	NOUN
admet-530	32	9	2	2	NUM
admet-530	32	10	)	)	PUNCT
admet-530	32	11	retrieves	retrieve	VERB
admet-530	32	12	the	the	DET
admet-530	32	13	relevant	relevant	ADJ
admet-530	32	14	compound	compound	NOUN
admet-530	32	15	information	information	NOUN
admet-530	32	16	from	from	ADP
admet-530	32	17	the	the	DET
admet-530	32	18	barcodes	barcode	NOUN
admet-530	32	19	and	and	CCONJ
admet-530	32	20	creates	create	VERB
admet-530	32	21	a	a	DET
admet-530	32	22	“	"	PUNCT
admet-530	32	23	worklist	worklist	NOUN
admet-530	32	24	”	"	PUNCT
admet-530	32	25	which	which	PRON
admet-530	32	26	is	be	AUX
admet-530	32	27	uploaded	upload	VERB
admet-530	32	28	into	into	ADP
admet-530	32	29	the	the	DET
admet-530	32	30	hplc	hplc	NOUN
admet-530	32	31	systems	system	NOUN
admet-530	32	32	and	and	CCONJ
admet-530	32	33	used	use	VERB
admet-530	32	34	for	for	ADP
admet-530	32	35	running	run	VERB
admet-530	32	36	the	the	DET
admet-530	32	37	samples	sample	NOUN
admet-530	32	38	.	.	PUNCT
admet-530	33	1	the	the	DET
admet-530	33	2	application	application	NOUN
admet-530	33	3	extracts	extract	VERB
admet-530	33	4	the	the	DET
admet-530	33	5	pertinent	pertinent	ADJ
admet-530	33	6	data	datum	NOUN
admet-530	33	7	from	from	ADP
admet-530	33	8	the	the	DET
admet-530	33	9	raw	raw	ADJ
admet-530	33	10	data	datum	NOUN
admet-530	33	11	and	and	CCONJ
admet-530	33	12	places	place	VERB
admet-530	33	13	it	it	PRON
admet-530	33	14	into	into	ADP
admet-530	33	15	an	an	DET
admet-530	33	16	excel	excel	NOUN
admet-530	33	17	spreadsheet	spreadsheet	NOUN
admet-530	33	18	where	where	SCONJ
admet-530	33	19	further	further	ADJ
admet-530	33	20	data	data	NOUN
admet-530	33	21	analysis	analysis	NOUN
admet-530	33	22	is	be	AUX
admet-530	33	23	conducted	conduct	VERB
admet-530	33	24	.	.	PUNCT
admet-530	34	1	the	the	DET
admet-530	34	2	automatic	automatic	ADJ
admet-530	34	3	extraction	extraction	NOUN
admet-530	34	4	of	of	ADP
admet-530	34	5	data	datum	NOUN
admet-530	34	6	is	be	AUX
admet-530	34	7	based	base	VERB
admet-530	34	8	on	on	ADP
admet-530	34	9	a	a	DET
admet-530	34	10	set	set	NOUN
admet-530	34	11	of	of	ADP
admet-530	34	12	user	user	NOUN
admet-530	34	13	-	-	PUNCT
admet-530	34	14	defined	define	VERB
admet-530	34	15	rules	rule	NOUN
admet-530	34	16	which	which	PRON
admet-530	34	17	interrogate	interrogate	VERB
admet-530	34	18	the	the	DET
admet-530	34	19	chromatograms	chromatogram	NOUN
admet-530	34	20	and	and	CCONJ
admet-530	34	21	flags	flag	VERB
admet-530	34	22	anomalous	anomalous	ADJ
admet-530	34	23	data	datum	NOUN
admet-530	34	24	,	,	PUNCT
admet-530	34	25	such	such	ADJ
admet-530	34	26	as	as	ADP
admet-530	34	27	multiple	multiple	ADJ
admet-530	34	28	peaks	peak	NOUN
admet-530	34	29	.	.	PUNCT
admet-530	35	1	this	this	PRON
admet-530	35	2	allows	allow	VERB
admet-530	35	3	more	more	ADV
admet-530	35	4	robust	robust	ADJ
admet-530	35	5	and	and	CCONJ
admet-530	35	6	efficient	efficient	ADJ
admet-530	35	7	data	datum	NOUN
admet-530	35	8	processing	processing	NOUN
admet-530	35	9	and	and	CCONJ
admet-530	35	10	analysis	analysis	NOUN
admet-530	35	11	.	.	PUNCT
admet-530	36	1	the	the	DET
admet-530	36	2	generation	generation	NOUN
admet-530	36	3	of	of	ADP
admet-530	36	4	such	such	ADJ
admet-530	36	5	volume	volume	NOUN
admet-530	36	6	of	of	ADP
admet-530	36	7	data	datum	NOUN
admet-530	36	8	has	have	AUX
admet-530	36	9	enabled	enable	VERB
admet-530	36	10	the	the	DET
admet-530	36	11	building	building	NOUN
admet-530	36	12	of	of	ADP
admet-530	36	13	high	high	ADJ
admet-530	36	14	quality	quality	NOUN
admet-530	36	15	in	in	ADP
admet-530	36	16	-	-	PUNCT
admet-530	36	17	house	house	NOUN
admet-530	36	18	predictive	predictive	ADJ
admet-530	36	19	models	model	NOUN
admet-530	36	20	(	(	PUNCT
admet-530	36	21	discussed	discuss	VERB
admet-530	36	22	later	later	ADV
admet-530	36	23	in	in	ADP
admet-530	36	24	this	this	DET
admet-530	36	25	publication	publication	NOUN
admet-530	36	26	)	)	PUNCT
admet-530	36	27	which	which	PRON
admet-530	36	28	are	be	AUX
admet-530	36	29	used	use	VERB
admet-530	36	30	for	for	ADP
admet-530	36	31	quality	quality	NOUN
admet-530	36	32	control	control	NOUN
admet-530	36	33	.	.	PUNCT
admet-530	37	1	comparison	comparison	NOUN
admet-530	37	2	of	of	ADP
admet-530	37	3	measured	measured	ADJ
admet-530	37	4	data	datum	NOUN
admet-530	37	5	with	with	ADP
admet-530	37	6	predicted	predict	VERB
admet-530	37	7	data	datum	NOUN
admet-530	37	8	using	use	VERB
admet-530	37	9	these	these	DET
admet-530	37	10	models	model	NOUN
admet-530	37	11	is	be	AUX
admet-530	37	12	routinely	routinely	ADV
admet-530	37	13	performed	perform	VERB
admet-530	37	14	to	to	PART
admet-530	37	15	highlight	highlight	VERB
admet-530	37	16	any	any	DET
admet-530	37	17	anomalous	anomalous	ADJ
admet-530	37	18	data	datum	NOUN
admet-530	37	19	.	.	PUNCT
admet-530	38	1	s.	s.	PROPN
admet-530	38	2	bunnally	bunnally	PROPN
admet-530	38	3	and	and	CCONJ
admet-530	38	4	r.j	r.j	PROPN
admet-530	38	5	.	.	PROPN
admet-530	38	6	young	young	ADJ
admet-530	38	7	admet	admet	PROPN
admet-530	38	8	&	&	CCONJ
admet-530	38	9	dmpk	dmpk	PROPN
admet-530	38	10	6(2	6(2	NUM
admet-530	38	11	)	)	PUNCT
admet-530	38	12	(	(	PUNCT
admet-530	38	13	2018	2018	NUM
admet-530	38	14	)	)	PUNCT
admet-530	38	15	74	74	NUM
admet-530	38	16	-	-	SYM
admet-530	38	17	84	84	NUM
admet-530	38	18	76	76	NUM
admet-530	38	19	figure	figure	NOUN
admet-530	38	20	1	1	NUM
admet-530	38	21	.	.	PUNCT
admet-530	39	1	the	the	DET
admet-530	39	2	gsk	gsk	NOUN
admet-530	39	3	high	high	ADJ
admet-530	39	4	throughput	throughput	NOUN
admet-530	39	5	physchem	physchem	PROPN
admet-530	39	6	sample	sample	NOUN
admet-530	39	7	preparation	preparation	NOUN
admet-530	39	8	workflow	workflow	NOUN
admet-530	39	9	in	in	ADP
admet-530	39	10	addition	addition	NOUN
admet-530	39	11	to	to	ADP
admet-530	39	12	the	the	DET
admet-530	39	13	kinetic	kinetic	ADJ
admet-530	39	14	solubility	solubility	NOUN
admet-530	39	15	data	datum	NOUN
admet-530	39	16	,	,	PUNCT
admet-530	39	17	this	this	DET
admet-530	39	18	process	process	NOUN
admet-530	39	19	enables	enable	VERB
admet-530	39	20	the	the	DET
admet-530	39	21	generation	generation	NOUN
admet-530	39	22	of	of	ADP
admet-530	39	23	high	high	ADJ
admet-530	39	24	-	-	PUNCT
admet-530	39	25	quality	quality	NOUN
admet-530	39	26	lipophilicity	lipophilicity	NOUN
admet-530	39	27	and	and	CCONJ
admet-530	39	28	biomimetic	biomimetic	ADJ
admet-530	39	29	binding	bind	VERB
admet-530	39	30	data	datum	NOUN
admet-530	39	31	for	for	ADP
admet-530	39	32	100	100	NUM
admet-530	39	33	’s	’s	NOUN
admet-530	39	34	of	of	ADP
admet-530	39	35	compounds	compound	NOUN
admet-530	39	36	to	to	PART
admet-530	39	37	be	be	AUX
admet-530	39	38	generated	generate	VERB
admet-530	39	39	weekly	weekly	ADJ
admet-530	39	40	.	.	PUNCT
admet-530	40	1	high	high	ADJ
admet-530	40	2	-	-	PUNCT
admet-530	40	3	performance	performance	NOUN
admet-530	40	4	liquid	liquid	ADJ
admet-530	40	5	chromatographic	chromatographic	ADJ
admet-530	40	6	(	(	PUNCT
admet-530	40	7	hplc	hplc	NOUN
admet-530	40	8	)	)	PUNCT
admet-530	40	9	based	base	VERB
admet-530	40	10	assays	assay	NOUN
admet-530	40	11	horváth	horváth	PROPN
admet-530	40	12	et	et	PROPN
admet-530	40	13	al	al	PROPN
admet-530	40	14	was	be	AUX
admet-530	40	15	amongst	amongst	ADP
admet-530	40	16	the	the	DET
admet-530	40	17	first	first	ADJ
admet-530	40	18	who	who	PRON
admet-530	40	19	used	use	VERB
admet-530	40	20	hplc	hplc	NOUN
admet-530	40	21	data	datum	NOUN
admet-530	40	22	for	for	ADP
admet-530	40	23	hydrophobicity	hydrophobicity	NOUN
admet-530	40	24	measurements	measurement	NOUN
admet-530	40	25	of	of	ADP
admet-530	40	26	amino	amino	ADJ
admet-530	40	27	acids	acid	NOUN
admet-530	40	28	[	[	X
admet-530	40	29	14	14	NUM
admet-530	40	30	]	]	PUNCT
admet-530	40	31	.	.	PUNCT
admet-530	41	1	it	it	PRON
admet-530	41	2	has	have	AUX
admet-530	41	3	been	be	AUX
admet-530	41	4	well	well	ADV
admet-530	41	5	described	describe	VERB
admet-530	41	6	that	that	SCONJ
admet-530	41	7	chromatographic	chromatographic	ADJ
admet-530	41	8	retention	retention	NOUN
admet-530	41	9	is	be	AUX
admet-530	41	10	related	relate	VERB
admet-530	41	11	to	to	ADP
admet-530	41	12	the	the	DET
admet-530	41	13	compound	compound	NOUN
admet-530	41	14	’s	’s	PART
admet-530	41	15	dynamic	dynamic	ADJ
admet-530	41	16	distribution	distribution	NOUN
admet-530	41	17	between	between	ADP
admet-530	41	18	the	the	DET
admet-530	41	19	stationary	stationary	ADJ
admet-530	41	20	and	and	CCONJ
admet-530	41	21	mobile	mobile	ADJ
admet-530	41	22	phases	phase	NOUN
admet-530	41	23	and	and	CCONJ
admet-530	41	24	this	this	PRON
admet-530	41	25	is	be	AUX
admet-530	41	26	governed	govern	VERB
admet-530	41	27	by	by	ADP
admet-530	41	28	a	a	DET
admet-530	41	29	compound	compound	NOUN
admet-530	41	30	’s	’s	PART
admet-530	41	31	hydrophobicity	hydrophobicity	NOUN
admet-530	42	1	[	[	X
admet-530	42	2	15	15	NUM
admet-530	42	3	-	-	SYM
admet-530	42	4	17	17	NUM
admet-530	42	5	]	]	PUNCT
admet-530	42	6	.	.	PUNCT
admet-530	43	1	hence	hence	ADV
admet-530	43	2	hplc	hplc	PROPN
admet-530	43	3	offers	offer	VERB
admet-530	43	4	an	an	DET
admet-530	43	5	excellent	excellent	ADJ
admet-530	43	6	automated	automate	VERB
admet-530	43	7	platform	platform	NOUN
admet-530	43	8	to	to	PART
admet-530	43	9	determine	determine	VERB
admet-530	43	10	distribution	distribution	NOUN
admet-530	43	11	coefficients	coefficient	NOUN
admet-530	43	12	of	of	ADP
admet-530	43	13	biologically	biologically	ADV
admet-530	43	14	active	active	ADJ
admet-530	43	15	compounds	compound	NOUN
admet-530	43	16	between	between	ADP
admet-530	43	17	aqueous	aqueous	ADJ
admet-530	43	18	mobile	mobile	ADJ
admet-530	43	19	phases	phase	NOUN
admet-530	43	20	and	and	CCONJ
admet-530	43	21	various	various	ADJ
admet-530	43	22	non	non	ADJ
admet-530	43	23	-	-	ADJ
admet-530	43	24	polar	polar	ADJ
admet-530	43	25	and	and	CCONJ
admet-530	43	26	biomimetic	biomimetic	ADJ
admet-530	43	27	stationary	stationary	ADJ
admet-530	43	28	phases	phase	NOUN
admet-530	43	29	through	through	ADP
admet-530	43	30	measurements	measurement	NOUN
admet-530	43	31	of	of	ADP
admet-530	43	32	retention	retention	NOUN
admet-530	43	33	times	time	NOUN
admet-530	43	34	.	.	PUNCT
admet-530	44	1	chromatographic	chromatographic	ADJ
admet-530	44	2	hydrophobicity	hydrophobicity	NOUN
admet-530	44	3	index	index	NOUN
admet-530	44	4	from	from	ADP
admet-530	44	5	fast	fast	ADJ
admet-530	44	6	gradient	gradient	PROPN
admet-530	44	7	c-18	c-18	PROPN
admet-530	44	8	hplc	hplc	NOUN
admet-530	44	9	:	:	PUNCT
admet-530	44	10	setting	set	VERB
admet-530	44	11	new	new	ADJ
admet-530	44	12	standards	standard	NOUN
admet-530	44	13	in	in	ADP
admet-530	44	14	lipophilicity	lipophilicity	NOUN
admet-530	44	15	/	/	SYM
admet-530	44	16	hydrophobicity	hydrophobicity	NOUN
admet-530	44	17	determinations	determination	NOUN
admet-530	44	18	the	the	DET
admet-530	44	19	lipophilicity	lipophilicity	NOUN
admet-530	44	20	values	value	NOUN
admet-530	44	21	of	of	ADP
admet-530	44	22	virtually	virtually	ADV
admet-530	44	23	all	all	DET
admet-530	44	24	new	new	ADJ
admet-530	44	25	compounds	compound	NOUN
admet-530	44	26	at	at	ADP
admet-530	44	27	gsk	gsk	NOUN
admet-530	44	28	is	be	AUX
admet-530	44	29	measured	measure	VERB
admet-530	44	30	by	by	ADP
admet-530	44	31	reversed	reverse	VERB
admet-530	44	32	phase	phase	NOUN
admet-530	44	33	hplc	hplc	NOUN
admet-530	44	34	using	use	VERB
admet-530	44	35	a	a	DET
admet-530	44	36	c-18	c-18	PROPN
admet-530	44	37	column	column	NOUN
admet-530	44	38	(	(	PUNCT
admet-530	44	39	50	50	NUM
admet-530	44	40	x	x	SYM
admet-530	44	41	2	2	NUM
admet-530	44	42	mm	mm	NOUN
admet-530	44	43	3	3	NUM
admet-530	44	44	µm	µm	ADP
admet-530	44	45	gemini	gemini	PROPN
admet-530	44	46	nx	nx	PROPN
admet-530	44	47	c18	c18	PROPN
admet-530	44	48	,	,	PUNCT
admet-530	44	49	phenomenex	phenomenex	ADV
admet-530	44	50	,	,	PUNCT
admet-530	44	51	uk	uk	PROPN
admet-530	44	52	)	)	PUNCT
admet-530	44	53	,	,	PUNCT
admet-530	44	54	at	at	ADP
admet-530	44	55	each	each	PRON
admet-530	44	56	of	of	ADP
admet-530	44	57	ph	ph	ADJ
admet-530	44	58	2	2	NUM
admet-530	44	59	,	,	PUNCT
admet-530	44	60	7.4	7.4	NUM
admet-530	44	61	and	and	CCONJ
admet-530	44	62	10.5	10.5	NUM
admet-530	44	63	,	,	PUNCT
admet-530	44	64	using	use	VERB
admet-530	44	65	buffered	buffer	VERB
admet-530	44	66	fast	fast	ADJ
admet-530	44	67	gradient	gradient	ADJ
admet-530	44	68	acetonitrile	acetonitrile	ADJ
admet-530	44	69	-	-	PUNCT
admet-530	44	70	water	water	NOUN
admet-530	44	71	mobile	mobile	ADJ
admet-530	44	72	phases	phase	NOUN
admet-530	44	73	.	.	PUNCT
admet-530	45	1	the	the	DET
admet-530	45	2	retention	retention	NOUN
admet-530	45	3	-	-	PUNCT
admet-530	45	4	time	time	NOUN
admet-530	45	5	derived	derive	VERB
admet-530	45	6	chromatographic	chromatographic	ADJ
admet-530	45	7	hydrophobicity	hydrophobicity	NOUN
admet-530	45	8	index	index	NOUN
admet-530	45	9	(	(	PUNCT
admet-530	45	10	chi	chi	NOUN
admet-530	45	11	)	)	PUNCT
admet-530	45	12	values	value	NOUN
admet-530	45	13	are	be	AUX
admet-530	45	14	derived	derive	VERB
admet-530	45	15	directly	directly	ADV
admet-530	45	16	from	from	ADP
admet-530	45	17	the	the	DET
admet-530	45	18	gradient	gradient	NOUN
admet-530	45	19	retention	retention	NOUN
admet-530	45	20	times	time	NOUN
admet-530	45	21	by	by	ADP
admet-530	45	22	using	use	VERB
admet-530	45	23	a	a	DET
admet-530	45	24	calibration	calibration	NOUN
admet-530	45	25	line	line	NOUN
admet-530	45	26	obtained	obtain	VERB
admet-530	45	27	for	for	ADP
admet-530	45	28	standard	standard	ADJ
admet-530	45	29	compounds	compound	NOUN
admet-530	45	30	[	[	X
admet-530	45	31	9	9	NUM
admet-530	45	32	]	]	PUNCT
admet-530	45	33	.	.	PUNCT
admet-530	46	1	translation	translation	NOUN
admet-530	46	2	of	of	ADP
admet-530	46	3	chi	chi	PROPN
admet-530	46	4	values	value	NOUN
admet-530	46	5	into	into	ADP
admet-530	46	6	chrom	chrom	PROPN
admet-530	46	7	log	log	NOUN
admet-530	46	8	d	d	NOUN
admet-530	46	9	values	value	NOUN
admet-530	46	10	at	at	ADP
admet-530	46	11	the	the	DET
admet-530	46	12	given	give	VERB
admet-530	46	13	ph	ph	NOUN
admet-530	46	14	is	be	AUX
admet-530	46	15	achieved	achieve	VERB
admet-530	46	16	using	use	VERB
admet-530	46	17	empirically	empirically	ADV
admet-530	46	18	-	-	PUNCT
admet-530	46	19	derived	derive	VERB
admet-530	46	20	equation	equation	NOUN
admet-530	46	21	1	1	NUM
admet-530	47	1	[	[	X
admet-530	47	2	10	10	NUM
admet-530	47	3	]	]	PUNCT
admet-530	47	4	.	.	PUNCT
admet-530	48	1	there	there	PRON
admet-530	48	2	is	be	VERB
admet-530	48	3	a	a	DET
admet-530	48	4	deliberate	deliberate	ADJ
admet-530	48	5	offset	offset	NOUN
admet-530	48	6	on	on	ADP
admet-530	48	7	the	the	DET
admet-530	48	8	scale	scale	NOUN
admet-530	48	9	to	to	PART
admet-530	48	10	differentiate	differentiate	VERB
admet-530	48	11	the	the	DET
admet-530	48	12	data	datum	NOUN
admet-530	48	13	from	from	ADP
admet-530	48	14	the	the	DET
admet-530	48	15	traditional	traditional	ADJ
admet-530	48	16	octanol	octanol	NOUN
admet-530	48	17	-	-	PUNCT
admet-530	48	18	water	water	NOUN
admet-530	48	19	measurements	measurement	NOUN
admet-530	48	20	,	,	PUNCT
admet-530	48	21	but	but	CCONJ
admet-530	48	22	there	there	PRON
admet-530	48	23	is	be	VERB
admet-530	48	24	a	a	DET
admet-530	48	25	high	high	ADJ
admet-530	48	26	correlation	correlation	NOUN
admet-530	48	27	between	between	ADP
admet-530	48	28	the	the	DET
admet-530	48	29	two	two	NUM
admet-530	48	30	(	(	PUNCT
admet-530	48	31	for	for	ADP
admet-530	48	32	soluble	soluble	ADJ
admet-530	48	33	compounds	compound	NOUN
admet-530	48	34	)	)	PUNCT
admet-530	48	35	.	.	PUNCT
admet-530	49	1	figure	figure	NOUN
admet-530	49	2	3	3	NUM
admet-530	49	3	indicates	indicate	VERB
admet-530	49	4	how	how	SCONJ
admet-530	49	5	the	the	DET
admet-530	49	6	charge	charge	NOUN
admet-530	49	7	profile	profile	NOUN
admet-530	49	8	of	of	ADP
admet-530	49	9	each	each	DET
admet-530	49	10	compound	compound	NOUN
admet-530	49	11	can	can	AUX
admet-530	49	12	be	be	AUX
admet-530	49	13	estimated	estimate	VERB
admet-530	49	14	based	base	VERB
admet-530	49	15	on	on	ADP
admet-530	49	16	the	the	DET
admet-530	49	17	changes	change	NOUN
admet-530	49	18	in	in	ADP
admet-530	49	19	logd	logd	NOUN
admet-530	49	20	across	across	ADP
admet-530	49	21	the	the	DET
admet-530	49	22	3	3	NUM
admet-530	49	23	ph	ph	ADJ
admet-530	49	24	values	value	NOUN
admet-530	49	25	.	.	PUNCT
admet-530	50	1	for	for	ADP
admet-530	50	2	neutral	neutral	ADJ
admet-530	50	3	molecules	molecule	NOUN
admet-530	50	4	,	,	PUNCT
admet-530	50	5	the	the	DET
admet-530	50	6	3	3	NUM
admet-530	50	7	are	be	AUX
admet-530	50	8	the	the	DET
admet-530	50	9	same	same	ADJ
admet-530	50	10	(	(	PUNCT
admet-530	50	11	i.e.	i.e.	X
admet-530	50	12	the	the	DET
admet-530	50	13	partition	partition	NOUN
admet-530	50	14	coefficient	coefficient	NOUN
admet-530	50	15	,	,	PUNCT
admet-530	50	16	chrom	chrom	PROPN
admet-530	50	17	log	log	NOUN
admet-530	50	18	p	p	PROPN
admet-530	50	19	)	)	PUNCT
admet-530	50	20	;	;	PUNCT
admet-530	50	21	additionally	additionally	ADV
admet-530	50	22	,	,	PUNCT
admet-530	50	23	the	the	DET
admet-530	50	24	highest	high	ADJ
admet-530	50	25	distribution	distribution	NOUN
admet-530	50	26	constant	constant	ADJ
admet-530	50	27	value	value	NOUN
admet-530	50	28	(	(	PUNCT
admet-530	50	29	for	for	ADP
admet-530	50	30	non	non	ADJ
admet-530	50	31	-	-	ADJ
admet-530	50	32	zwitterionic	zwitterionic	ADJ
admet-530	50	33	compounds	compound	NOUN
admet-530	50	34	)	)	PUNCT
admet-530	50	35	is	be	AUX
admet-530	50	36	usually	usually	ADV
admet-530	50	37	a	a	DET
admet-530	50	38	reliable	reliable	ADJ
admet-530	50	39	estimate	estimate	NOUN
admet-530	50	40	of	of	ADP
admet-530	50	41	the	the	DET
admet-530	50	42	chrom	chrom	NOUN
admet-530	50	43	log	log	NOUN
admet-530	50	44	p	p	PROPN
admet-530	50	45	of	of	ADP
admet-530	50	46	the	the	DET
admet-530	50	47	molecule	molecule	NOUN
admet-530	50	48	.	.	PUNCT
admet-530	51	1	chrom	chrom	PROPN
admet-530	51	2	log	log	PROPN
admet-530	51	3	d	d	PROPN
admet-530	51	4	=	=	PUNCT
admet-530	51	5	(	(	PUNCT
admet-530	51	6	0.0857)*chi	0.0857)*chi	NOUN
admet-530	51	7	2.00	2.00	NUM
admet-530	51	8	.	.	PUNCT
admet-530	52	1	(	(	PUNCT
admet-530	52	2	1	1	X
admet-530	52	3	)	)	PUNCT
admet-530	52	4	admet	admet	PROPN
admet-530	52	5	&	&	CCONJ
admet-530	52	6	dmpk	dmpk	PROPN
admet-530	52	7	6(2	6(2	NUM
admet-530	52	8	)	)	PUNCT
admet-530	52	9	(	(	PUNCT
admet-530	52	10	2018	2018	NUM
admet-530	52	11	)	)	PUNCT
admet-530	52	12	74	74	NUM
admet-530	52	13	-	-	SYM
admet-530	52	14	84	84	NUM
admet-530	52	15	high	high	ADJ
admet-530	52	16	throughput	throughput	NOUN
admet-530	52	17	biomimetic	biomimetic	ADJ
admet-530	52	18	measurements	measurement	NOUN
admet-530	52	19	in	in	ADP
admet-530	52	20	drug	drug	NOUN
admet-530	52	21	discovery	discovery	NOUN
admet-530	52	22	doi	doi	PROPN
admet-530	52	23	:	:	PUNCT
admet-530	52	24	10.5599	10.5599	NUM
admet-530	52	25	/	/	SYM
admet-530	52	26	admet.530	admet.530	VERB
admet-530	52	27	77	77	NUM
admet-530	52	28	figure	figure	NOUN
admet-530	52	29	2	2	NUM
admet-530	52	30	.	.	PUNCT
admet-530	53	1	use	use	NOUN
admet-530	53	2	of	of	ADP
admet-530	53	3	the	the	DET
admet-530	53	4	physchem	physchem	NOUN
admet-530	53	5	application	application	NOUN
admet-530	53	6	for	for	ADP
admet-530	53	7	data	datum	NOUN
admet-530	53	8	analysis	analysis	NOUN
admet-530	53	9	charge	charge	NOUN
admet-530	53	10	characteristic	characteristic	ADJ
admet-530	53	11	chrom	chrom	NOUN
admet-530	53	12	log	log	NOUN
admet-530	53	13	d	d	PROPN
admet-530	53	14	at	at	ADP
admet-530	53	15	ph	ph	ADJ
admet-530	53	16	:	:	PUNCT
admet-530	53	17	neutral	neutral	ADJ
admet-530	53	18	weak	weak	ADJ
admet-530	53	19	acid	acid	NOUN
admet-530	53	20	strong	strong	ADJ
admet-530	53	21	acid	acid	ADJ
admet-530	53	22	weak	weak	ADJ
admet-530	53	23	base	base	NOUN
admet-530	53	24	strong	strong	ADJ
admet-530	53	25	base	base	NOUN
admet-530	53	26	2	2	NUM
admet-530	53	27	=	=	SYM
admet-530	53	28	x	x	SYM
admet-530	53	29	=	=	PUNCT
admet-530	53	30	x	x	PUNCT
admet-530	53	31	>	>	PUNCT
admet-530	53	32	x	x	X
admet-530	53	33	<	<	X
admet-530	53	34	x	x	X
admet-530	53	35	=	=	SYM
admet-530	53	36	x	x	SYM
admet-530	53	37	7.4	7.4	NUM
admet-530	53	38	x	x	SYM
admet-530	53	39	x	x	PUNCT
admet-530	53	40	x	x	PUNCT
admet-530	53	41	x	x	SYM
admet-530	53	42	x	x	X
admet-530	53	43	10.5	10.5	NUM
admet-530	53	44	=	=	NOUN
admet-530	53	45	x	x	PUNCT
admet-530	53	46	<	<	X
admet-530	53	47	x	x	X
admet-530	53	48	=	=	PUNCT
admet-530	53	49	x	x	SYM
admet-530	53	50	=	=	PUNCT
admet-530	53	51	x	x	PUNCT
admet-530	53	52	>	>	PUNCT
admet-530	53	53	x	x	PUNCT
admet-530	53	54	figure	figure	NOUN
admet-530	54	1	3	3	NUM
admet-530	54	2	.	.	PUNCT
admet-530	54	3	patterns	pattern	NOUN
admet-530	54	4	of	of	ADP
admet-530	54	5	changes	change	NOUN
admet-530	54	6	in	in	ADP
admet-530	54	7	log	log	NOUN
admet-530	54	8	dph	dph	PROPN
admet-530	54	9	,	,	PUNCT
admet-530	54	10	at	at	ADP
admet-530	54	11	high	high	ADJ
admet-530	54	12	or	or	CCONJ
admet-530	54	13	low	low	ADJ
admet-530	54	14	ph	ph	VERB
admet-530	54	15	,	,	PUNCT
admet-530	54	16	compared	compare	VERB
admet-530	54	17	to	to	ADP
admet-530	54	18	the	the	DET
admet-530	54	19	measured	measure	VERB
admet-530	54	20	value	value	NOUN
admet-530	54	21	,	,	PUNCT
admet-530	54	22	x	x	PRON
admet-530	54	23	,	,	PUNCT
admet-530	54	24	at	at	ADP
admet-530	54	25	ph	ph	PROPN
admet-530	54	26	7.4	7.4	NUM
admet-530	54	27	,	,	PUNCT
admet-530	54	28	used	use	VERB
admet-530	54	29	to	to	PART
admet-530	54	30	classify	classify	VERB
admet-530	54	31	the	the	DET
admet-530	54	32	strength	strength	NOUN
admet-530	54	33	of	of	ADP
admet-530	54	34	charged	charge	VERB
admet-530	54	35	motifs	motif	NOUN
admet-530	54	36	in	in	ADP
admet-530	54	37	compounds	compound	NOUN
admet-530	54	38	.	.	PUNCT
admet-530	55	1	the	the	DET
admet-530	55	2	influence	influence	NOUN
admet-530	55	3	and	and	CCONJ
admet-530	55	4	impact	impact	NOUN
admet-530	55	5	of	of	ADP
admet-530	55	6	these	these	DET
admet-530	55	7	chromatographic	chromatographic	ADJ
admet-530	55	8	measurements	measurement	NOUN
admet-530	55	9	[	[	X
admet-530	55	10	1,10	1,10	NUM
admet-530	55	11	]	]	PUNCT
admet-530	55	12	reflect	reflect	VERB
admet-530	55	13	other	other	ADJ
admet-530	55	14	observations	observation	NOUN
admet-530	55	15	on	on	ADP
admet-530	55	16	the	the	DET
admet-530	55	17	crucial	crucial	ADJ
admet-530	55	18	role	role	NOUN
admet-530	55	19	of	of	ADP
admet-530	55	20	modulating	modulate	VERB
admet-530	55	21	lipophilicity	lipophilicity	NOUN
admet-530	55	22	in	in	ADP
admet-530	55	23	drug	drug	NOUN
admet-530	55	24	discovery	discovery	NOUN
admet-530	56	1	[	[	X
admet-530	56	2	2,18	2,18	X
admet-530	56	3	]	]	X
admet-530	56	4	,	,	PUNCT
admet-530	56	5	both	both	CCONJ
admet-530	56	6	through	through	ADP
admet-530	56	7	their	their	PRON
admet-530	56	8	impact	impact	NOUN
admet-530	56	9	in	in	ADP
admet-530	56	10	building	build	VERB
admet-530	56	11	rational	rational	ADJ
admet-530	56	12	understandings	understanding	NOUN
admet-530	56	13	of	of	ADP
admet-530	56	14	both	both	DET
admet-530	56	15	admet	admet	X
admet-530	56	16	outcomes	outcome	NOUN
admet-530	56	17	and	and	CCONJ
admet-530	56	18	chances	chance	NOUN
admet-530	56	19	of	of	ADP
admet-530	56	20	successful	successful	ADJ
admet-530	56	21	compound	compound	NOUN
admet-530	56	22	progression	progression	NOUN
admet-530	56	23	.	.	PUNCT
admet-530	57	1	increasingly	increasingly	ADV
admet-530	57	2	,	,	PUNCT
admet-530	57	3	appreciation	appreciation	NOUN
admet-530	57	4	of	of	ADP
admet-530	57	5	the	the	DET
admet-530	57	6	impact	impact	NOUN
admet-530	57	7	of	of	ADP
admet-530	57	8	maximising	maximise	VERB
admet-530	57	9	lipophilic	lipophilic	ADJ
admet-530	57	10	ligand	ligand	NOUN
admet-530	57	11	efficiency	efficiency	NOUN
admet-530	57	12	is	be	AUX
admet-530	57	13	driving	drive	VERB
admet-530	57	14	drug	drug	NOUN
admet-530	57	15	discovery	discovery	NOUN
admet-530	57	16	thinking	thinking	NOUN
admet-530	57	17	;	;	PUNCT
admet-530	57	18	this	this	PRON
admet-530	57	19	embodies	embody	VERB
admet-530	57	20	the	the	DET
admet-530	57	21	“	"	PUNCT
admet-530	57	22	minimum	minimum	ADJ
admet-530	57	23	lipophilicity	lipophilicity	NOUN
admet-530	57	24	principle	principle	NOUN
admet-530	57	25	”	"	PUNCT
admet-530	57	26	proposed	propose	VERB
admet-530	57	27	by	by	ADP
admet-530	57	28	hansch	hansch	PROPN
admet-530	57	29	[	[	X
admet-530	57	30	19	19	NUM
admet-530	57	31	]	]	PUNCT
admet-530	57	32	,	,	PUNCT
admet-530	57	33	who	who	PRON
admet-530	57	34	proposed	propose	VERB
admet-530	57	35	that	that	SCONJ
admet-530	57	36	“	"	PUNCT
admet-530	57	37	compounds	compound	NOUN
admet-530	57	38	should	should	AUX
admet-530	57	39	be	be	AUX
admet-530	57	40	made	make	VERB
admet-530	57	41	as	as	ADV
admet-530	57	42	hydrophilic	hydrophilic	NOUN
admet-530	57	43	as	as	ADP
admet-530	57	44	possible	possible	ADJ
admet-530	57	45	without	without	ADP
admet-530	57	46	loss	loss	NOUN
admet-530	57	47	of	of	ADP
admet-530	57	48	efficacy	efficacy	NOUN
admet-530	57	49	”	"	PUNCT
admet-530	57	50	by	by	ADP
admet-530	57	51	subtracting	subtract	VERB
admet-530	57	52	lipophilicity	lipophilicity	NOUN
admet-530	57	53	from	from	ADP
admet-530	57	54	potency	potency	NOUN
admet-530	57	55	(	(	PUNCT
admet-530	57	56	usually	usually	ADV
admet-530	57	57	expressed	express	VERB
admet-530	57	58	as	as	ADP
admet-530	57	59	ligand	ligand	NOUN
admet-530	57	60	lipophilicity	lipophilicity	NOUN
admet-530	57	61	efficiency	efficiency	NOUN
admet-530	57	62	,	,	PUNCT
admet-530	57	63	lle	lle	NOUN
admet-530	57	64	=	=	SYM
admet-530	57	65	pic50	pic50	NOUN
admet-530	57	66	–	–	PUNCT
admet-530	57	67	log	log	NOUN
admet-530	57	68	p	p	NOUN
admet-530	57	69	)	)	PUNCT
admet-530	58	1	[	[	X
admet-530	58	2	20	20	NUM
admet-530	58	3	]	]	PUNCT
admet-530	58	4	.	.	PUNCT
admet-530	59	1	furthermore	furthermore	ADV
admet-530	59	2	,	,	PUNCT
admet-530	59	3	the	the	DET
admet-530	59	4	principle	principle	NOUN
admet-530	59	5	of	of	ADP
admet-530	59	6	concurrently	concurrently	ADV
admet-530	59	7	minimising	minimise	VERB
admet-530	59	8	lipophilicity	lipophilicity	NOUN
admet-530	59	9	and	and	CCONJ
admet-530	59	10	aromaticity	aromaticity	NOUN
admet-530	59	11	[	[	X
admet-530	59	12	21	21	NUM
admet-530	59	13	]	]	PUNCT
admet-530	59	14	is	be	AUX
admet-530	59	15	represented	represent	VERB
admet-530	59	16	by	by	ADP
admet-530	59	17	the	the	DET
admet-530	59	18	property	property	NOUN
admet-530	59	19	forecast	forecast	NOUN
admet-530	59	20	index	index	NOUN
admet-530	59	21	(	(	PUNCT
admet-530	59	22	pfi	pfi	NOUN
admet-530	59	23	)	)	PUNCT
admet-530	59	24	,	,	PUNCT
admet-530	59	25	the	the	DET
admet-530	59	26	summation	summation	NOUN
admet-530	59	27	of	of	ADP
admet-530	59	28	aromatic	aromatic	ADJ
admet-530	59	29	ring	ring	NOUN
admet-530	59	30	count	count	NOUN
admet-530	60	1	[	[	X
admet-530	60	2	22,23	22,23	NOUN
admet-530	60	3	]	]	X
admet-530	60	4	and	and	CCONJ
admet-530	60	5	a	a	DET
admet-530	60	6	lipophilicity	lipophilicity	NOUN
admet-530	60	7	measure	measure	NOUN
admet-530	60	8	.	.	PUNCT
admet-530	61	1	the	the	DET
admet-530	61	2	measured	measure	VERB
admet-530	61	3	pfi	pfi	NOUN
admet-530	61	4	(	(	PUNCT
admet-530	61	5	chrom	chrom	NOUN
admet-530	61	6	log	log	NOUN
admet-530	61	7	d7.4	d7.4	PROPN
admet-530	61	8	+	+	CCONJ
admet-530	61	9	#	#	NUM
admet-530	61	10	ar	ar	NOUN
admet-530	61	11	)	)	PUNCT
admet-530	61	12	is	be	AUX
admet-530	61	13	an	an	DET
admet-530	61	14	integral	integral	ADJ
admet-530	61	15	part	part	NOUN
admet-530	61	16	of	of	ADP
admet-530	61	17	gsk	gsk	NOUN
admet-530	61	18	candidate	candidate	NOUN
admet-530	61	19	quality	quality	NOUN
admet-530	61	20	aspirations	aspiration	NOUN
admet-530	61	21	[	[	PUNCT
admet-530	61	22	13	13	NUM
admet-530	61	23	]	]	PUNCT
admet-530	61	24	,	,	PUNCT
admet-530	61	25	based	base	VERB
admet-530	61	26	on	on	ADP
admet-530	61	27	analyses	analysis	NOUN
admet-530	61	28	of	of	ADP
admet-530	61	29	marketed	market	VERB
admet-530	61	30	drugs	drug	NOUN
admet-530	61	31	and	and	CCONJ
admet-530	61	32	internal	internal	ADJ
admet-530	61	33	attrition	attrition	NOUN
admet-530	61	34	;	;	PUNCT
admet-530	61	35	ideally	ideally	ADV
admet-530	61	36	an	an	DET
admet-530	61	37	oral	oral	ADJ
admet-530	61	38	candidate	candidate	NOUN
admet-530	61	39	should	should	AUX
admet-530	61	40	have	have	VERB
admet-530	61	41	pfi	pfi	NOUN
admet-530	61	42	<	<	NOUN
admet-530	61	43	6	6	NUM
admet-530	61	44	,	,	PUNCT
admet-530	61	45	fasted	fast	VERB
admet-530	61	46	-	-	PUNCT
admet-530	61	47	state	state	NOUN
admet-530	61	48	simulated	simulate	VERB
admet-530	61	49	intestinal	intestinal	ADJ
admet-530	61	50	fluid	fluid	NOUN
admet-530	61	51	(	(	PUNCT
admet-530	61	52	fassif	fassif	NOUN
admet-530	61	53	)	)	PUNCT
admet-530	61	54	solubility	solubility	NOUN
admet-530	61	55	>	>	X
admet-530	61	56	100	100	NUM
admet-530	61	57	g	g	PROPN
admet-530	61	58	/	/	SYM
admet-530	61	59	ml	ml	PROPN
admet-530	61	60	and	and	CCONJ
admet-530	61	61	a	a	DET
admet-530	61	62	predicted	predict	VERB
admet-530	61	63	dose	dose	NOUN
admet-530	61	64	of	of	ADP
admet-530	61	65	<	<	X
admet-530	61	66	100	100	NUM
admet-530	61	67	mg	mg	NOUN
admet-530	61	68	.	.	PUNCT
admet-530	62	1	s.	s.	PROPN
admet-530	62	2	bunnally	bunnally	PROPN
admet-530	62	3	and	and	CCONJ
admet-530	62	4	r.j	r.j	PROPN
admet-530	62	5	.	.	PROPN
admet-530	62	6	young	young	ADJ
admet-530	62	7	admet	admet	PROPN
admet-530	62	8	&	&	CCONJ
admet-530	62	9	dmpk	dmpk	PROPN
admet-530	62	10	6(2	6(2	NUM
admet-530	62	11	)	)	PUNCT
admet-530	62	12	(	(	PUNCT
admet-530	62	13	2018	2018	NUM
admet-530	62	14	)	)	PUNCT
admet-530	62	15	74	74	NUM
admet-530	62	16	-	-	SYM
admet-530	62	17	84	84	NUM
admet-530	62	18	78	78	NUM
admet-530	62	19	protein	protein	NOUN
admet-530	62	20	binding	bind	VERB
admet-530	62	21	assay	assay	NOUN
admet-530	62	22	chemically	chemically	ADV
admet-530	62	23	bonded	bond	VERB
admet-530	62	24	hsa	hsa	PROPN
admet-530	62	25	hplc	hplc	PROPN
admet-530	62	26	stationary	stationary	ADJ
admet-530	62	27	phase	phase	NOUN
admet-530	62	28	with	with	ADP
admet-530	62	29	column	column	NOUN
admet-530	62	30	dimension	dimension	NOUN
admet-530	62	31	of	of	ADP
admet-530	62	32	50	50	NUM
admet-530	62	33	x	x	SYM
admet-530	62	34	3	3	NUM
admet-530	62	35	mm	mm	INTJ
admet-530	62	36	(	(	PUNCT
admet-530	62	37	chiral	chiral	ADJ
admet-530	62	38	technologies	technology	NOUN
admet-530	62	39	,	,	PUNCT
admet-530	62	40	france	france	PROPN
admet-530	62	41	)	)	PUNCT
admet-530	62	42	are	be	AUX
admet-530	62	43	used	use	VERB
admet-530	62	44	for	for	ADP
admet-530	62	45	measuring	measure	VERB
admet-530	62	46	compounds	compound	NOUN
admet-530	62	47	’	'	PUNCT
admet-530	62	48	binding	bind	VERB
admet-530	62	49	to	to	ADP
admet-530	62	50	plasma	plasma	NOUN
admet-530	62	51	proteins	protein	NOUN
admet-530	62	52	by	by	ADP
admet-530	62	53	applying	apply	VERB
admet-530	62	54	linear	linear	PROPN
admet-530	62	55	gradient	gradient	ADJ
admet-530	62	56	elution	elution	NOUN
admet-530	62	57	up	up	ADP
admet-530	62	58	to	to	PART
admet-530	62	59	30	30	NUM
admet-530	62	60	%	%	NOUN
admet-530	62	61	iso	iso	NOUN
admet-530	62	62	-	-	PUNCT
admet-530	62	63	propanol	propanol	NOUN
admet-530	62	64	with	with	ADP
admet-530	62	65	50	50	NUM
admet-530	62	66	mm	mm	NOUN
admet-530	62	67	ammonium	ammonium	NOUN
admet-530	62	68	acetate	acetate	NOUN
admet-530	62	69	buffer	buffer	NOUN
admet-530	62	70	,	,	PUNCT
admet-530	62	71	ph	ph	NOUN
admet-530	62	72	7.4	7.4	NUM
admet-530	63	1	[	[	X
admet-530	63	2	24	24	NUM
admet-530	63	3	]	]	PUNCT
admet-530	63	4	.	.	PUNCT
admet-530	64	1	the	the	DET
admet-530	64	2	gradient	gradient	ADJ
admet-530	64	3	retention	retention	NOUN
admet-530	64	4	times	time	NOUN
admet-530	64	5	are	be	AUX
admet-530	64	6	standardised	standardise	VERB
admet-530	64	7	using	use	VERB
admet-530	64	8	a	a	DET
admet-530	64	9	calibration	calibration	NOUN
admet-530	64	10	set	set	NOUN
admet-530	64	11	of	of	ADP
admet-530	64	12	mixtures	mixture	NOUN
admet-530	64	13	.	.	PUNCT
admet-530	65	1	the	the	DET
admet-530	65	2	%	%	NOUN
admet-530	65	3	hsa	hsa	PROPN
admet-530	65	4	bound	bind	VERB
admet-530	65	5	gives	give	VERB
admet-530	65	6	a	a	DET
admet-530	65	7	reliable	reliable	ADJ
admet-530	65	8	indication	indication	NOUN
admet-530	65	9	of	of	ADP
admet-530	65	10	the	the	DET
admet-530	65	11	free	free	ADJ
admet-530	65	12	fraction	fraction	NOUN
admet-530	65	13	of	of	ADP
admet-530	65	14	the	the	DET
admet-530	65	15	compound	compound	NOUN
admet-530	65	16	in	in	ADP
admet-530	65	17	plasma	plasma	NOUN
admet-530	65	18	when	when	SCONJ
admet-530	65	19	compared	compare	VERB
admet-530	65	20	to	to	ADP
admet-530	65	21	more	more	ADV
admet-530	65	22	complex	complex	ADJ
admet-530	65	23	pharmacokinetic	pharmacokinetic	ADJ
admet-530	65	24	methods	method	NOUN
admet-530	65	25	.	.	PUNCT
admet-530	66	1	the	the	DET
admet-530	66	2	%	%	NOUN
admet-530	66	3	hsa	hsa	PROPN
admet-530	66	4	is	be	AUX
admet-530	66	5	converted	convert	VERB
admet-530	66	6	to	to	ADP
admet-530	66	7	the	the	DET
admet-530	66	8	affinity	affinity	NOUN
admet-530	66	9	constant	constant	ADJ
admet-530	66	10	,	,	PUNCT
admet-530	66	11	log	log	PROPN
admet-530	66	12	khsa	khsa	NOUN
admet-530	66	13	,	,	PUNCT
admet-530	66	14	using	use	VERB
admet-530	66	15	equation	equation	NOUN
admet-530	66	16	2	2	NUM
admet-530	66	17	:	:	PUNCT
admet-530	66	18	log	log	VERB
admet-530	66	19	khsa	khsa	NOUN
admet-530	67	1	=	=	NOUN
admet-530	67	2	log	log	PROPN
admet-530	68	1	[	[	X
admet-530	68	2	hsa%	hsa%	NOUN
admet-530	68	3	/	/	SYM
admet-530	68	4	(	(	PUNCT
admet-530	68	5	101	101	NUM
admet-530	68	6	-	-	PUNCT
admet-530	68	7	hsa%	hsa%	NOUN
admet-530	68	8	)	)	PUNCT
admet-530	68	9	]	]	PUNCT
admet-530	68	10	(	(	PUNCT
admet-530	68	11	2	2	X
admet-530	68	12	)	)	PUNCT
admet-530	68	13	figure	figure	NOUN
admet-530	69	1	4	4	NUM
admet-530	69	2	.	.	PUNCT
admet-530	70	1	a	a	DET
admet-530	70	2	)	)	PUNCT
admet-530	70	3	levels	level	NOUN
admet-530	70	4	of	of	ADP
admet-530	70	5	hsa	hsa	PROPN
admet-530	70	6	binding	bind	VERB
admet-530	70	7	by	by	ADP
admet-530	70	8	hplc	hplc	PROPN
admet-530	70	9	measurement	measurement	NOUN
admet-530	70	10	,	,	PUNCT
admet-530	70	11	log	log	PROPN
admet-530	70	12	khsa	khsa	NOUN
admet-530	70	13	plotted	plot	VERB
admet-530	70	14	versus	versus	ADP
admet-530	70	15	chrom	chrom	PROPN
admet-530	70	16	log	log	NOUN
admet-530	70	17	d7.4	d7.4	PROPN
admet-530	70	18	with	with	ADP
admet-530	70	19	charges	charge	NOUN
admet-530	70	20	highlighted	highlight	VERB
admet-530	70	21	(	(	PUNCT
admet-530	70	22	see	see	VERB
admet-530	70	23	figure	figure	NOUN
admet-530	70	24	3	3	NUM
admet-530	70	25	)	)	PUNCT
admet-530	70	26	and	and	CCONJ
admet-530	70	27	b	b	X
admet-530	70	28	)	)	PUNCT
admet-530	70	29	box	box	NOUN
admet-530	70	30	-	-	PUNCT
admet-530	70	31	whisker	whisker	NOUN
admet-530	70	32	plot	plot	NOUN
admet-530	70	33	of	of	ADP
admet-530	70	34	log	log	NOUN
admet-530	70	35	khsa	khsa	NOUN
admet-530	70	36	vs	vs	ADP
admet-530	70	37	binned	bin	VERB
admet-530	70	38	measured	measure	VERB
admet-530	70	39	pfi	pfi	NOUN
admet-530	70	40	for	for	ADP
admet-530	70	41	gsk	gsk	NOUN
admet-530	70	42	compounds	compound	NOUN
admet-530	70	43	,	,	PUNCT
admet-530	70	44	wherein	wherein	SCONJ
admet-530	70	45	khsa	khsa	NOUN
admet-530	71	1	=	=	PUNCT
admet-530	72	1	[	[	X
admet-530	72	2	%	%	INTJ
admet-530	72	3	hsa	hsa	AUX
admet-530	72	4	binding/(101-%hsa	binding/(101-%hsa	NOUN
admet-530	72	5	binding	bind	VERB
admet-530	72	6	)	)	PUNCT
admet-530	72	7	]	]	PUNCT
admet-530	73	1	using	use	VERB
admet-530	73	2	the	the	DET
admet-530	73	3	%	%	NOUN
admet-530	73	4	binding	bind	VERB
admet-530	73	5	values	value	NOUN
admet-530	73	6	derived	derive	VERB
admet-530	73	7	from	from	ADP
admet-530	73	8	chromatographic	chromatographic	ADJ
admet-530	73	9	measurements	measurement	NOUN
admet-530	73	10	.	.	PUNCT
admet-530	74	1	analysis	analysis	NOUN
admet-530	74	2	of	of	ADP
admet-530	74	3	data	datum	NOUN
admet-530	74	4	derived	derive	VERB
admet-530	74	5	from	from	ADP
admet-530	74	6	the	the	DET
admet-530	74	7	hsa	hsa	PROPN
admet-530	74	8	measurements	measurement	NOUN
admet-530	74	9	show	show	VERB
admet-530	74	10	a	a	DET
admet-530	74	11	clear	clear	ADJ
admet-530	74	12	increase	increase	NOUN
admet-530	74	13	in	in	ADP
admet-530	74	14	hsa	hsa	NOUN
admet-530	74	15	binding	bind	VERB
admet-530	74	16	with	with	ADP
admet-530	74	17	increasing	increase	VERB
admet-530	74	18	lipophilicity	lipophilicity	NOUN
admet-530	74	19	(	(	PUNCT
admet-530	74	20	figure	figure	NOUN
admet-530	74	21	4a	4a	NUM
admet-530	74	22	)	)	PUNCT
admet-530	74	23	;	;	PUNCT
admet-530	74	24	when	when	SCONJ
admet-530	74	25	separated	separate	VERB
admet-530	74	26	by	by	ADP
admet-530	74	27	charge	charge	NOUN
admet-530	74	28	,	,	PUNCT
admet-530	74	29	the	the	DET
admet-530	74	30	increased	increase	VERB
admet-530	74	31	propensity	propensity	NOUN
admet-530	74	32	for	for	ADP
admet-530	74	33	binding	bind	VERB
admet-530	74	34	by	by	ADP
admet-530	74	35	acidic	acidic	ADJ
admet-530	74	36	a	a	DET
admet-530	74	37	)	)	PUNCT
admet-530	74	38	b	b	NOUN
admet-530	74	39	)	)	PUNCT
admet-530	74	40	admet	admet	PROPN
admet-530	74	41	&	&	CCONJ
admet-530	74	42	dmpk	dmpk	PROPN
admet-530	74	43	6(2	6(2	NUM
admet-530	74	44	)	)	PUNCT
admet-530	74	45	(	(	PUNCT
admet-530	74	46	2018	2018	NUM
admet-530	74	47	)	)	PUNCT
admet-530	74	48	74	74	NUM
admet-530	74	49	-	-	SYM
admet-530	74	50	84	84	NUM
admet-530	74	51	high	high	ADJ
admet-530	74	52	throughput	throughput	NOUN
admet-530	74	53	biomimetic	biomimetic	ADJ
admet-530	74	54	measurements	measurement	NOUN
admet-530	74	55	in	in	ADP
admet-530	74	56	drug	drug	NOUN
admet-530	74	57	discovery	discovery	NOUN
admet-530	74	58	doi	doi	PROPN
admet-530	74	59	:	:	PUNCT
admet-530	74	60	10.5599	10.5599	NUM
admet-530	74	61	/	/	SYM
admet-530	74	62	admet.530	admet.530	VERB
admet-530	74	63	79	79	NUM
admet-530	74	64	compounds	compound	NOUN
admet-530	74	65	,	,	PUNCT
admet-530	74	66	over	over	ADV
admet-530	74	67	and	and	CCONJ
admet-530	74	68	above	above	ADP
admet-530	74	69	their	their	PRON
admet-530	74	70	lipophilicity	lipophilicity	NOUN
admet-530	74	71	,	,	PUNCT
admet-530	74	72	is	be	AUX
admet-530	74	73	evident	evident	ADJ
admet-530	74	74	.	.	PUNCT
admet-530	75	1	the	the	DET
admet-530	75	2	impact	impact	NOUN
admet-530	75	3	of	of	ADP
admet-530	75	4	aromaticity	aromaticity	NOUN
admet-530	75	5	on	on	ADP
admet-530	75	6	hsa	hsa	PROPN
admet-530	75	7	binding	bind	VERB
admet-530	75	8	is	be	AUX
admet-530	75	9	also	also	ADV
admet-530	75	10	clear	clear	ADJ
admet-530	75	11	,	,	PUNCT
admet-530	75	12	given	give	VERB
admet-530	75	13	higher	high	ADJ
admet-530	75	14	binding	binding	NOUN
admet-530	75	15	as	as	ADP
admet-530	75	16	pfi	pfi	NOUN
admet-530	75	17	increases	increase	NOUN
admet-530	75	18	(	(	PUNCT
admet-530	75	19	figure	figure	NOUN
admet-530	75	20	4b	4b	PROPN
admet-530	75	21	)	)	PUNCT
admet-530	75	22	.	.	PUNCT
admet-530	76	1	phospholipid	phospholipid	NOUN
admet-530	76	2	binding	bind	VERB
admet-530	76	3	assay	assay	VERB
admet-530	76	4	the	the	DET
admet-530	76	5	binding	binding	NOUN
admet-530	76	6	of	of	ADP
admet-530	76	7	compounds	compound	NOUN
admet-530	76	8	to	to	ADP
admet-530	76	9	the	the	DET
admet-530	76	10	immobilised	immobilised	ADJ
admet-530	76	11	artificial	artificial	ADJ
admet-530	76	12	membrane	membrane	NOUN
admet-530	76	13	(	(	PUNCT
admet-530	76	14	iam	iam	PROPN
admet-530	76	15	)	)	PUNCT
admet-530	77	1	[	[	X
admet-530	77	2	25	25	NUM
admet-530	77	3	]	]	PUNCT
admet-530	77	4	is	be	AUX
admet-530	77	5	measured	measure	VERB
admet-530	77	6	using	use	VERB
admet-530	77	7	commercially	commercially	ADV
admet-530	77	8	available	available	ADJ
admet-530	77	9	immobilised	immobilised	ADJ
admet-530	77	10	phosphatidylcholine	phosphatidylcholine	NOUN
admet-530	77	11	(	(	PUNCT
admet-530	77	12	pc	pc	NOUN
admet-530	77	13	dd2	dd2	PROPN
admet-530	77	14	100	100	NUM
admet-530	77	15	x	x	SYM
admet-530	77	16	4.6	4.6	NUM
admet-530	77	17	mm	mm	NUM
admet-530	77	18	10	10	NUM
admet-530	77	19	µm	µm	NOUN
admet-530	77	20	,	,	PUNCT
admet-530	77	21	regis	regis	PROPN
admet-530	77	22	analytical	analytical	PROPN
admet-530	77	23	,	,	PUNCT
admet-530	77	24	west	west	PROPN
admet-530	77	25	lafayette	lafayette	PROPN
admet-530	77	26	,	,	PUNCT
admet-530	77	27	usa	usa	PROPN
admet-530	77	28	)	)	PUNCT
admet-530	77	29	hplc	hplc	NOUN
admet-530	77	30	columns	column	NOUN
admet-530	78	1	[	[	X
admet-530	78	2	26	26	NUM
admet-530	78	3	]	]	PUNCT
admet-530	78	4	.	.	PUNCT
admet-530	79	1	gradient	gradient	ADJ
admet-530	79	2	retention	retention	NOUN
admet-530	79	3	times	time	NOUN
admet-530	79	4	obtained	obtain	VERB
admet-530	79	5	by	by	ADP
admet-530	79	6	applying	apply	VERB
admet-530	79	7	an	an	DET
admet-530	79	8	acetonitrile	acetonitrile	ADJ
admet-530	79	9	gradient	gradient	NOUN
admet-530	79	10	up	up	ADP
admet-530	79	11	to	to	PART
admet-530	79	12	85	85	NUM
admet-530	79	13	%	%	NOUN
admet-530	79	14	are	be	AUX
admet-530	79	15	converted	convert	VERB
admet-530	79	16	to	to	ADP
admet-530	79	17	chromatographic	chromatographic	ADJ
admet-530	79	18	hydrophobicity	hydrophobicity	NOUN
admet-530	79	19	indices	index	NOUN
admet-530	79	20	(	(	PUNCT
admet-530	79	21	chiiam	chiiam	PROPN
admet-530	79	22	)	)	PUNCT
admet-530	79	23	using	use	VERB
admet-530	79	24	a	a	DET
admet-530	79	25	calibration	calibration	NOUN
admet-530	79	26	set	set	NOUN
admet-530	79	27	of	of	ADP
admet-530	79	28	compounds	compound	NOUN
admet-530	79	29	.	.	PUNCT
admet-530	80	1	the	the	DET
admet-530	80	2	chiiam	chiiam	PROPN
admet-530	80	3	values	value	NOUN
admet-530	80	4	are	be	AUX
admet-530	80	5	converted	convert	VERB
admet-530	80	6	to	to	ADP
admet-530	80	7	the	the	DET
admet-530	80	8	logarithmic	logarithmic	ADJ
admet-530	80	9	retention	retention	NOUN
admet-530	80	10	factors	factor	NOUN
admet-530	80	11	using	use	VERB
admet-530	80	12	the	the	DET
admet-530	80	13	following	follow	VERB
admet-530	80	14	formula	formula	NOUN
admet-530	80	15	:	:	PUNCT
admet-530	80	16	log	log	VERB
admet-530	80	17	kiam	kiam	PROPN
admet-530	81	1	=	=	PUNCT
admet-530	82	1	0.046*chiiam	0.046*chiiam	PROPN
admet-530	83	1	+	+	CCONJ
admet-530	84	1	0.42	0.42	NUM
admet-530	84	2	.	.	PUNCT
admet-530	85	1	chiiam	chiiam	PROPN
admet-530	85	2	binding	binding	NOUN
admet-530	85	3	gives	give	VERB
admet-530	85	4	an	an	DET
admet-530	85	5	indication	indication	NOUN
admet-530	85	6	of	of	ADP
admet-530	85	7	the	the	DET
admet-530	85	8	compound	compound	NOUN
admet-530	85	9	’s	’s	PART
admet-530	85	10	likely	likely	ADV
admet-530	85	11	binding	bind	VERB
admet-530	85	12	to	to	ADP
admet-530	85	13	tissues	tissue	NOUN
admet-530	85	14	and	and	CCONJ
admet-530	85	15	further	further	ADJ
admet-530	85	16	insights	insight	NOUN
admet-530	85	17	are	be	AUX
admet-530	85	18	emerging	emerge	VERB
admet-530	85	19	[	[	PUNCT
admet-530	85	20	27	27	NUM
admet-530	85	21	]	]	PUNCT
admet-530	85	22	,	,	PUNCT
admet-530	85	23	notably	notably	ADV
admet-530	85	24	semi	semi	ADJ
admet-530	85	25	-	-	ADJ
admet-530	85	26	quantitative	quantitative	ADJ
admet-530	85	27	indicators	indicator	NOUN
admet-530	85	28	of	of	ADP
admet-530	85	29	the	the	DET
admet-530	85	30	risk	risk	NOUN
admet-530	85	31	of	of	ADP
admet-530	85	32	phospholipidosis	phospholipidosis	NOUN
admet-530	85	33	[	[	X
admet-530	85	34	28	28	NUM
admet-530	85	35	]	]	X
admet-530	85	36	,	,	PUNCT
admet-530	85	37	a	a	DET
admet-530	85	38	cytotoxicity	cytotoxicity	NOUN
admet-530	85	39	outcome	outcome	NOUN
admet-530	85	40	characterised	characterise	VERB
admet-530	85	41	by	by	ADP
admet-530	85	42	the	the	DET
admet-530	85	43	breakdown	breakdown	NOUN
admet-530	85	44	of	of	ADP
admet-530	85	45	phospholipids	phospholipid	NOUN
admet-530	85	46	[	[	X
admet-530	85	47	29	29	NUM
admet-530	85	48	]	]	PUNCT
admet-530	85	49	,	,	PUNCT
admet-530	85	50	due	due	ADP
admet-530	85	51	to	to	ADP
admet-530	85	52	cationic	cationic	ADJ
admet-530	85	53	amphiphilic	amphiphilic	ADJ
admet-530	85	54	drugs	drug	NOUN
admet-530	85	55	(	(	PUNCT
admet-530	85	56	cads	cad	NOUN
admet-530	85	57	)	)	PUNCT
admet-530	85	58	.	.	PUNCT
admet-530	86	1	the	the	DET
admet-530	86	2	gsk	gsk	NOUN
admet-530	86	3	model	model	NOUN
admet-530	86	4	is	be	AUX
admet-530	86	5	based	base	VERB
admet-530	86	6	on	on	ADP
admet-530	86	7	the	the	DET
admet-530	86	8	equation	equation	NOUN
admet-530	86	9	cad	cad	NOUN
admet-530	86	10	likeness	likeness	NOUN
admet-530	86	11	=	=	PUNCT
admet-530	86	12	chiiam	chiiam	PROPN
admet-530	86	13	+	+	CCONJ
admet-530	86	14	delta	delta	NOUN
admet-530	86	15	chi	chi	NOUN
admet-530	86	16	,	,	PUNCT
admet-530	86	17	whereby	whereby	SCONJ
admet-530	86	18	delta	delta	NOUN
admet-530	86	19	chi	chi	NOUN
admet-530	86	20	=	=	PUNCT
admet-530	86	21	(	(	PUNCT
admet-530	86	22	chiph10.5	chiph10.5	VERB
admet-530	86	23	–	–	PUNCT
admet-530	86	24	chiph7.4	chiph7.4	NUM
admet-530	86	25	)	)	PUNCT
admet-530	86	26	as	as	SCONJ
admet-530	86	27	measured	measure	VERB
admet-530	86	28	in	in	ADP
admet-530	86	29	the	the	DET
admet-530	86	30	c-18	c-18	PROPN
admet-530	86	31	assays	assay	NOUN
admet-530	86	32	at	at	ADP
admet-530	86	33	the	the	DET
admet-530	86	34	given	give	VERB
admet-530	86	35	ph	ph	ADJ
admet-530	86	36	values	value	NOUN
admet-530	86	37	.	.	PUNCT
admet-530	87	1	unsurprisingly	unsurprisingly	ADV
admet-530	87	2	,	,	PUNCT
admet-530	87	3	given	give	VERB
admet-530	87	4	the	the	DET
admet-530	87	5	hydrophobic	hydrophobic	NOUN
admet-530	87	6	chains	chain	NOUN
admet-530	87	7	of	of	ADP
admet-530	87	8	the	the	DET
admet-530	87	9	phosphatidylcholine	phosphatidylcholine	NOUN
admet-530	87	10	,	,	PUNCT
admet-530	87	11	iam	iam	PROPN
admet-530	87	12	binding	bind	VERB
admet-530	87	13	is	be	AUX
admet-530	87	14	driven	drive	VERB
admet-530	87	15	by	by	ADP
admet-530	87	16	lipophilicity	lipophilicity	NOUN
admet-530	87	17	,	,	PUNCT
admet-530	87	18	but	but	CCONJ
admet-530	87	19	,	,	PUNCT
admet-530	87	20	in	in	ADP
admet-530	87	21	contrast	contrast	NOUN
admet-530	87	22	to	to	ADP
admet-530	87	23	acid	acid	NOUN
admet-530	87	24	-	-	PUNCT
admet-530	87	25	binding	bind	VERB
admet-530	87	26	hsa	hsa	NOUN
admet-530	87	27	,	,	PUNCT
admet-530	87	28	the	the	DET
admet-530	87	29	net	net	ADJ
admet-530	87	30	negative	negative	ADJ
admet-530	87	31	charge	charge	NOUN
admet-530	87	32	of	of	ADP
admet-530	87	33	the	the	DET
admet-530	87	34	phosphates	phosphate	NOUN
admet-530	87	35	leads	lead	VERB
admet-530	87	36	to	to	ADP
admet-530	87	37	enhanced	enhanced	ADJ
admet-530	87	38	binding	bind	VERB
admet-530	87	39	of	of	ADP
admet-530	87	40	basic	basic	ADJ
admet-530	87	41	molecules	molecule	NOUN
admet-530	87	42	(	(	PUNCT
admet-530	87	43	figure	figure	NOUN
admet-530	87	44	5	5	NUM
admet-530	87	45	)	)	PUNCT
admet-530	87	46	.	.	PUNCT
admet-530	88	1	figure	figure	NOUN
admet-530	88	2	5	5	NUM
admet-530	88	3	.	.	PUNCT
admet-530	89	1	levels	level	NOUN
admet-530	89	2	of	of	ADP
admet-530	89	3	iam	iam	PROPN
admet-530	89	4	binding	bind	VERB
admet-530	89	5	by	by	ADP
admet-530	89	6	hplc	hplc	NOUN
admet-530	89	7	measurement	measurement	NOUN
admet-530	89	8	(	(	PUNCT
admet-530	89	9	expressed	express	VERB
admet-530	89	10	as	as	ADP
admet-530	89	11	log	log	NOUN
admet-530	89	12	kiam	kiam	PROPN
admet-530	89	13	=	=	PUNCT
admet-530	90	1	0.046*chiiam	0.046*chiiam	PROPN
admet-530	91	1	+	+	CCONJ
admet-530	92	1	0.42	0.42	NUM
admet-530	92	2	)	)	PUNCT
admet-530	92	3	versus	versus	ADP
admet-530	92	4	chrom	chrom	PROPN
admet-530	92	5	log	log	NOUN
admet-530	92	6	d7.4	d7.4	PROPN
admet-530	92	7	with	with	ADP
admet-530	92	8	bases	basis	NOUN
admet-530	92	9	highlighted	highlight	VERB
admet-530	92	10	drug	drug	NOUN
admet-530	92	11	efficiency	efficiency	NOUN
admet-530	92	12	,	,	PUNCT
admet-530	92	13	hplc	hplc	NOUN
admet-530	92	14	demax	demax	NOUN
admet-530	92	15	drug	drug	NOUN
admet-530	92	16	efficiency	efficiency	NOUN
admet-530	92	17	(	(	PUNCT
admet-530	92	18	de	de	X
admet-530	92	19	,	,	PUNCT
admet-530	92	20	equation	equation	NOUN
admet-530	92	21	3	3	NUM
admet-530	92	22	)	)	PUNCT
admet-530	92	23	is	be	AUX
admet-530	92	24	a	a	DET
admet-530	92	25	concept	concept	NOUN
admet-530	92	26	based	base	VERB
admet-530	92	27	on	on	ADP
admet-530	92	28	measured	measure	VERB
admet-530	92	29	pharmacokinetic	pharmacokinetic	ADJ
admet-530	92	30	parameters	parameter	NOUN
admet-530	92	31	,	,	PUNCT
admet-530	92	32	designed	design	VERB
admet-530	92	33	to	to	PART
admet-530	92	34	guide	guide	VERB
admet-530	92	35	lead	lead	NOUN
admet-530	92	36	optimisation	optimisation	NOUN
admet-530	92	37	and	and	CCONJ
admet-530	92	38	developability	developability	NOUN
admet-530	92	39	assessment	assessment	NOUN
admet-530	92	40	,	,	PUNCT
admet-530	92	41	which	which	PRON
admet-530	92	42	reflects	reflect	VERB
admet-530	92	43	the	the	DET
admet-530	92	44	free	free	ADJ
admet-530	92	45	plasma	plasma	NOUN
admet-530	92	46	concentration	concentration	NOUN
admet-530	92	47	at	at	ADP
admet-530	92	48	the	the	DET
admet-530	92	49	site	site	NOUN
admet-530	92	50	of	of	ADP
admet-530	92	51	action	action	NOUN
admet-530	92	52	(	(	PUNCT
admet-530	92	53	expressed	express	VERB
admet-530	92	54	as	as	ADP
admet-530	92	55	the	the	DET
admet-530	92	56	fraction	fraction	NOUN
admet-530	92	57	of	of	ADP
admet-530	92	58	the	the	DET
admet-530	92	59	dose	dose	NOUN
admet-530	92	60	)	)	PUNCT
admet-530	93	1	[	[	X
admet-530	93	2	30	30	NUM
admet-530	93	3	]	]	PUNCT
admet-530	93	4	.	.	PUNCT
admet-530	94	1	measured	measure	VERB
admet-530	94	2	de	de	PROPN
admet-530	94	3	data	datum	NOUN
admet-530	94	4	correlate	correlate	VERB
admet-530	94	5	with	with	ADP
admet-530	94	6	hplc	hplc	NOUN
admet-530	94	7	demax	demax	NOUN
admet-530	94	8	values	value	NOUN
admet-530	94	9	(	(	PUNCT
admet-530	94	10	equation	equation	NOUN
admet-530	94	11	4	4	NUM
admet-530	94	12	)	)	PUNCT
admet-530	94	13	,	,	PUNCT
admet-530	94	14	generated	generate	VERB
admet-530	95	1	biomimetically	biomimetically	ADV
admet-530	95	2	[	[	X
admet-530	95	3	31	31	NUM
admet-530	95	4	]	]	PUNCT
admet-530	95	5	,	,	PUNCT
admet-530	95	6	using	use	VERB
admet-530	95	7	a	a	DET
admet-530	95	8	combination	combination	NOUN
admet-530	95	9	of	of	ADP
admet-530	95	10	hsa	hsa	PROPN
admet-530	95	11	and	and	CCONJ
admet-530	95	12	iam	iam	PROPN
admet-530	95	13	columns	column	NOUN
admet-530	95	14	figure	figure	VERB
admet-530	95	15	6	6	NUM
admet-530	95	16	.	.	PUNCT
admet-530	96	1	the	the	DET
admet-530	96	2	empirically	empirically	ADV
admet-530	96	3	-	-	PUNCT
admet-530	96	4	derived	derive	VERB
admet-530	96	5	model	model	NOUN
admet-530	96	6	generated	generate	VERB
admet-530	96	7	from	from	ADP
admet-530	96	8	the	the	DET
admet-530	96	9	data	datum	NOUN
admet-530	96	10	[	[	X
admet-530	96	11	32	32	NUM
admet-530	96	12	]	]	PUNCT
admet-530	96	13	is	be	AUX
admet-530	96	14	based	base	VERB
admet-530	96	15	on	on	ADP
admet-530	96	16	the	the	DET
admet-530	96	17	notion	notion	NOUN
admet-530	96	18	that	that	SCONJ
admet-530	96	19	the	the	DET
admet-530	96	20	unbound	unbound	NOUN
admet-530	96	21	concentration	concentration	NOUN
admet-530	96	22	is	be	AUX
admet-530	96	23	influenced	influence	VERB
admet-530	96	24	by	by	ADP
admet-530	96	25	both	both	DET
admet-530	96	26	plasma	plasma	NOUN
admet-530	96	27	protein	protein	NOUN
admet-530	96	28	binding	bind	VERB
admet-530	96	29	(	(	PUNCT
admet-530	96	30	hsa	hsa	PROPN
admet-530	96	31	data	data	PROPN
admet-530	96	32	)	)	PUNCT
admet-530	96	33	and	and	CCONJ
admet-530	96	34	the	the	DET
admet-530	96	35	volume	volume	NOUN
admet-530	96	36	of	of	ADP
admet-530	96	37	distribution	distribution	NOUN
admet-530	96	38	,	,	PUNCT
admet-530	96	39	for	for	ADP
admet-530	96	40	which	which	PRON
admet-530	96	41	the	the	DET
admet-530	96	42	hplc	hplc	NOUN
admet-530	96	43	iam	iam	PROPN
admet-530	96	44	data	datum	NOUN
admet-530	96	45	provides	provide	VERB
admet-530	96	46	an	an	DET
admet-530	96	47	excellent	excellent	ADJ
admet-530	96	48	surrogate	surrogate	NOUN
admet-530	96	49	for	for	SCONJ
admet-530	96	50	the	the	DET
admet-530	96	51	contributory	contributory	ADJ
admet-530	96	52	tissue	tissue	NOUN
admet-530	96	53	binding	bind	VERB
admet-530	96	54	[	[	X
admet-530	96	55	33	33	NUM
admet-530	96	56	]	]	PUNCT
admet-530	96	57	.	.	PUNCT
admet-530	97	1	increasingly	increasingly	ADV
admet-530	97	2	,	,	PUNCT
admet-530	97	3	these	these	DET
admet-530	97	4	measurements	measurement	NOUN
admet-530	97	5	are	be	AUX
admet-530	97	6	having	have	VERB
admet-530	97	7	an	an	DET
admet-530	97	8	impact	impact	NOUN
admet-530	97	9	in	in	ADP
admet-530	97	10	decision	decision	NOUN
admet-530	97	11	making	making	NOUN
admet-530	97	12	,	,	PUNCT
admet-530	97	13	through	through	ADP
admet-530	97	14	estimation	estimation	NOUN
admet-530	97	15	of	of	ADP
admet-530	97	16	clinical	clinical	ADJ
admet-530	97	17	dose	dose	NOUN
admet-530	97	18	[	[	X
admet-530	97	19	34	34	NUM
admet-530	97	20	]	]	PUNCT
admet-530	97	21	,	,	PUNCT
admet-530	97	22	and	and	CCONJ
admet-530	97	23	are	be	AUX
admet-530	97	24	being	be	AUX
admet-530	97	25	generated	generate	VERB
admet-530	97	26	prospectively	prospectively	ADV
admet-530	97	27	with	with	ADP
admet-530	97	28	in	in	ADP
admet-530	97	29	silico	silico	NOUN
admet-530	97	30	models	model	NOUN
admet-530	97	31	available	available	ADJ
admet-530	97	32	at	at	ADP
admet-530	97	33	gsk	gsk	NOUN
admet-530	97	34	.	.	PUNCT
admet-530	98	1	the	the	DET
admet-530	98	2	influence	influence	NOUN
admet-530	98	3	of	of	ADP
admet-530	98	4	s.	s.	PROPN
admet-530	98	5	bunnally	bunnally	PROPN
admet-530	98	6	and	and	CCONJ
admet-530	98	7	r.j	r.j	PROPN
admet-530	98	8	.	.	PROPN
admet-530	98	9	young	young	ADJ
admet-530	98	10	admet	admet	PROPN
admet-530	98	11	&	&	CCONJ
admet-530	98	12	dmpk	dmpk	PROPN
admet-530	98	13	6(2	6(2	NUM
admet-530	98	14	)	)	PUNCT
admet-530	98	15	(	(	PUNCT
admet-530	98	16	2018	2018	NUM
admet-530	98	17	)	)	PUNCT
admet-530	98	18	74	74	NUM
admet-530	98	19	-	-	SYM
admet-530	98	20	84	84	NUM
admet-530	98	21	80	80	NUM
admet-530	98	22	hplc	hplc	NOUN
admet-530	98	23	demax	demax	NOUN
admet-530	98	24	data	datum	NOUN
admet-530	98	25	on	on	ADP
admet-530	98	26	the	the	DET
admet-530	98	27	selection	selection	NOUN
admet-530	98	28	of	of	ADP
admet-530	98	29	compounds	compound	NOUN
admet-530	98	30	for	for	ADP
admet-530	98	31	progression	progression	NOUN
admet-530	98	32	is	be	AUX
admet-530	98	33	illustrated	illustrate	VERB
admet-530	98	34	in	in	ADP
admet-530	98	35	figure	figure	NOUN
admet-530	98	36	7	7	NUM
admet-530	98	37	for	for	ADP
admet-530	98	38	a	a	DET
admet-530	98	39	gsk	gsk	NOUN
admet-530	98	40	programme	programme	NOUN
admet-530	98	41	,	,	PUNCT
admet-530	98	42	where	where	SCONJ
admet-530	98	43	most	most	ADJ
admet-530	98	44	compounds	compound	NOUN
admet-530	98	45	had	have	VERB
admet-530	98	46	similar	similar	ADJ
admet-530	98	47	potencies	potency	NOUN
admet-530	98	48	(	(	PUNCT
admet-530	98	49	pic50	pic50	NOUN
admet-530	98	50	7	7	NUM
admet-530	98	51	to	to	ADP
admet-530	98	52	8)	8)	NUM
admet-530	98	53	but	but	CCONJ
admet-530	98	54	a	a	DET
admet-530	98	55	range	range	NOUN
admet-530	98	56	of	of	ADP
admet-530	98	57	hplc	hplc	NOUN
admet-530	98	58	demax	demax	NOUN
admet-530	98	59	values	value	NOUN
admet-530	98	60	.	.	PUNCT
admet-530	99	1	the	the	DET
admet-530	99	2	candidates	candidate	NOUN
admet-530	99	3	selected	select	VERB
admet-530	99	4	from	from	ADP
admet-530	99	5	this	this	DET
admet-530	99	6	set	set	NOUN
admet-530	99	7	have	have	VERB
admet-530	99	8	hplc	hplc	NOUN
admet-530	99	9	demax	demax	NOUN
admet-530	99	10	>	>	X
admet-530	99	11	1	1	NUM
admet-530	99	12	%	%	NOUN
admet-530	99	13	and	and	CCONJ
admet-530	99	14	are	be	AUX
admet-530	99	15	in	in	ADP
admet-530	99	16	the	the	DET
admet-530	99	17	same	same	ADJ
admet-530	99	18	space	space	NOUN
admet-530	99	19	as	as	ADP
admet-530	99	20	the	the	DET
admet-530	99	21	profiled	profile	VERB
admet-530	99	22	drugs	drug	NOUN
admet-530	99	23	.	.	PUNCT
admet-530	100	1	these	these	DET
admet-530	100	2	hplc	hplc	NOUN
admet-530	100	3	measurements	measurement	NOUN
admet-530	100	4	,	,	PUNCT
admet-530	100	5	pertinent	pertinent	ADJ
admet-530	100	6	to	to	ADP
admet-530	100	7	demax	demax	PROPN
admet-530	100	8	,	,	PUNCT
admet-530	100	9	are	be	AUX
admet-530	100	10	increasingly	increasingly	ADV
admet-530	100	11	being	be	AUX
admet-530	100	12	gathered	gather	VERB
admet-530	100	13	in	in	ADP
admet-530	100	14	programmes	programme	NOUN
admet-530	100	15	at	at	ADP
admet-530	100	16	gsk	gsk	NOUN
admet-530	100	17	and	and	CCONJ
admet-530	100	18	are	be	AUX
admet-530	100	19	starting	start	VERB
admet-530	100	20	to	to	PART
admet-530	100	21	influence	influence	VERB
admet-530	100	22	thinking	thinking	NOUN
admet-530	100	23	,	,	PUNCT
admet-530	100	24	design	design	NOUN
admet-530	100	25	and	and	CCONJ
admet-530	100	26	decision	decision	NOUN
admet-530	100	27	making	making	NOUN
admet-530	100	28	.	.	PUNCT
admet-530	101	1	biophaseconc	biophaseconc	ADJ
admet-530	101	2	(	(	PUNCT
admet-530	101	3	µg	µg	ADJ
admet-530	101	4	/	/	SYM
admet-530	101	5	ml	ml	NOUN
admet-530	101	6	)	)	PUNCT
admet-530	101	7	drug	drug	NOUN
admet-530	101	8	eff	eff	PROPN
admet-530	101	9	%	%	NOUN
admet-530	101	10	=	=	SYM
admet-530	102	1	x100	x100	PROPN
admet-530	102	2	dose	dose	PROPN
admet-530	102	3	(	(	PUNCT
admet-530	102	4	µg	µg	NOUN
admet-530	102	5	/	/	SYM
admet-530	102	6	g	g	NOUN
admet-530	102	7	)	)	PUNCT
admet-530	102	8	(	(	PUNCT
admet-530	102	9	3	3	X
admet-530	102	10	)	)	PUNCT
admet-530	102	11	log	log	NOUN
admet-530	102	12	hplc	hplc	NOUN
admet-530	102	13	demax	demax	NOUN
admet-530	102	14	=	=	SYM
admet-530	102	15	2	2	X
admet-530	102	16	–	–	PUNCT
admet-530	102	17	(	(	PUNCT
admet-530	102	18	0.23	0.23	NUM
admet-530	102	19	*	*	PUNCT
admet-530	102	20	log	log	NOUN
admet-530	102	21	khsa	khsa	NOUN
admet-530	102	22	+	+	CCONJ
admet-530	102	23	0.43	0.43	NUM
admet-530	102	24	*	*	PUNCT
admet-530	102	25	log	log	PROPN
admet-530	102	26	kiam	kiam	PROPN
admet-530	102	27	-0.72	-0.72	PROPN
admet-530	102	28	)	)	PUNCT
admet-530	102	29	(	(	PUNCT
admet-530	102	30	4	4	X
admet-530	102	31	)	)	PUNCT
admet-530	102	32	drug	drug	NOUN
admet-530	102	33	efficiency	efficiency	NOUN
admet-530	102	34	max	max	PROPN
admet-530	102	35	(	(	PUNCT
admet-530	102	36	demax	demax	PROPN
admet-530	102	37	)	)	PUNCT
admet-530	102	38	is	be	AUX
admet-530	102	39	the	the	DET
admet-530	102	40	maximum	maximum	ADJ
admet-530	102	41	in	in	ADP
admet-530	102	42	vivo	vivo	ADJ
admet-530	102	43	drug	drug	NOUN
admet-530	102	44	efficiency	efficiency	NOUN
admet-530	102	45	that	that	PRON
admet-530	102	46	could	could	AUX
admet-530	102	47	theoretically	theoretically	ADV
admet-530	102	48	be	be	AUX
admet-530	102	49	achieved	achieve	VERB
admet-530	102	50	assuming	assume	VERB
admet-530	102	51	100	100	NUM
admet-530	102	52	%	%	NOUN
admet-530	102	53	oral	oral	ADJ
admet-530	102	54	absorption	absorption	NOUN
admet-530	102	55	,	,	PUNCT
admet-530	102	56	no	no	DET
admet-530	102	57	clearance	clearance	NOUN
admet-530	102	58	,	,	PUNCT
admet-530	102	59	free	free	ADJ
admet-530	102	60	permeability	permeability	NOUN
admet-530	102	61	,	,	PUNCT
admet-530	102	62	and	and	CCONJ
admet-530	102	63	no	no	DET
admet-530	102	64	active	active	ADJ
admet-530	102	65	transport	transport	NOUN
admet-530	102	66	.	.	PUNCT
admet-530	103	1	high	high	ADJ
admet-530	103	2	potency	potency	NOUN
admet-530	103	3	plus	plus	CCONJ
admet-530	103	4	high	high	ADJ
admet-530	103	5	drug	drug	NOUN
admet-530	103	6	efficiency	efficiency	NOUN
admet-530	103	7	=	=	SYM
admet-530	103	8	lower	low	ADJ
admet-530	103	9	dose	dose	VERB
admet-530	103	10	lower	low	ADJ
admet-530	103	11	dose	dose	NOUN
admet-530	103	12	leads	lead	NOUN
admet-530	103	13	to	to	PART
admet-530	103	14	reduced	reduce	VERB
admet-530	103	15	off	off	ADP
admet-530	103	16	-	-	PUNCT
admet-530	103	17	target	target	NOUN
admet-530	103	18	risks	risk	NOUN
admet-530	103	19	.	.	PUNCT
admet-530	104	1	this	this	PRON
admet-530	104	2	contributes	contribute	VERB
admet-530	104	3	to	to	ADP
admet-530	104	4	reduced	reduce	VERB
admet-530	104	5	attrition	attrition	NOUN
admet-530	104	6	.	.	PUNCT
admet-530	105	1	figure	figure	NOUN
admet-530	105	2	6	6	NUM
admet-530	105	3	.	.	PUNCT
admet-530	106	1	the	the	DET
admet-530	106	2	plot	plot	NOUN
admet-530	106	3	of	of	ADP
admet-530	106	4	log	log	NOUN
admet-530	106	5	(	(	PUNCT
admet-530	106	6	in	in	ADP
admet-530	106	7	vivo	vivo	NOUN
admet-530	106	8	de	de	NOUN
admet-530	106	9	)	)	PUNCT
admet-530	106	10	vs	vs	ADP
admet-530	106	11	log	log	NOUN
admet-530	106	12	(	(	PUNCT
admet-530	106	13	hplc	hplc	PROPN
admet-530	106	14	demax	demax	NOUN
admet-530	106	15	)	)	PUNCT
admet-530	106	16	values	value	NOUN
admet-530	106	17	for	for	ADP
admet-530	106	18	the	the	DET
admet-530	106	19	training	training	NOUN
admet-530	106	20	set	set	NOUN
admet-530	106	21	of	of	ADP
admet-530	106	22	known	known	ADJ
admet-530	106	23	drugs	drug	NOUN
admet-530	106	24	an	an	DET
admet-530	106	25	additional	additional	ADJ
admet-530	106	26	parameter	parameter	NOUN
admet-530	106	27	,	,	PUNCT
admet-530	106	28	the	the	DET
admet-530	106	29	drug	drug	NOUN
admet-530	106	30	efficiency	efficiency	NOUN
admet-530	106	31	index	index	NOUN
admet-530	106	32	(	(	PUNCT
admet-530	106	33	dei	dei	NOUN
admet-530	106	34	)	)	PUNCT
admet-530	107	1	[	[	X
admet-530	107	2	29	29	NUM
admet-530	107	3	]	]	PUNCT
admet-530	107	4	,	,	PUNCT
admet-530	107	5	can	can	AUX
admet-530	107	6	be	be	AUX
admet-530	107	7	generated	generate	VERB
admet-530	107	8	by	by	ADP
admet-530	107	9	the	the	DET
admet-530	107	10	summation	summation	NOUN
admet-530	107	11	of	of	ADP
admet-530	107	12	pxc50	pxc50	PROPN
admet-530	107	13	and	and	CCONJ
admet-530	107	14	log10	log10	PROPN
admet-530	107	15	(	(	PUNCT
admet-530	107	16	hplc	hplc	PROPN
admet-530	107	17	demax	demax	PROPN
admet-530	107	18	)	)	PUNCT
admet-530	107	19	;	;	PUNCT
admet-530	107	20	dei	dei	NOUN
admet-530	107	21	gives	give	VERB
admet-530	107	22	an	an	DET
admet-530	107	23	estimate	estimate	NOUN
admet-530	107	24	of	of	ADP
admet-530	107	25	the	the	DET
admet-530	107	26	likely	likely	ADJ
admet-530	107	27	effective	effective	ADJ
admet-530	107	28	activity	activity	NOUN
admet-530	107	29	at	at	ADP
admet-530	107	30	the	the	DET
admet-530	107	31	site	site	NOUN
admet-530	107	32	of	of	ADP
admet-530	107	33	action	action	NOUN
admet-530	107	34	,	,	PUNCT
admet-530	107	35	i.e.	i.e.	X
admet-530	107	36	potency	potency	NOUN
admet-530	107	37	corrected	correct	VERB
admet-530	107	38	for	for	ADP
admet-530	107	39	the	the	DET
admet-530	107	40	free	free	ADJ
admet-530	107	41	concentration	concentration	NOUN
admet-530	107	42	.	.	PUNCT
admet-530	108	1	impact	impact	NOUN
admet-530	108	2	of	of	ADP
admet-530	108	3	measurements	measurement	NOUN
admet-530	108	4	to	to	PART
admet-530	108	5	enable	enable	VERB
admet-530	108	6	,	,	PUNCT
admet-530	108	7	validate	validate	VERB
admet-530	108	8	and	and	CCONJ
admet-530	108	9	improve	improve	VERB
admet-530	108	10	predictive	predictive	ADJ
admet-530	108	11	methods	method	NOUN
admet-530	108	12	data	datum	NOUN
admet-530	108	13	collected	collect	VERB
admet-530	108	14	by	by	ADP
admet-530	108	15	the	the	DET
admet-530	108	16	various	various	ADJ
admet-530	108	17	biomimetic	biomimetic	ADJ
admet-530	108	18	measurements	measurement	NOUN
admet-530	108	19	has	have	AUX
admet-530	108	20	enabled	enable	VERB
admet-530	108	21	the	the	DET
admet-530	108	22	building	building	NOUN
admet-530	108	23	of	of	ADP
admet-530	108	24	high	high	ADJ
admet-530	108	25	quality	quality	NOUN
admet-530	108	26	inhouse	inhouse	NOUN
admet-530	108	27	predictive	predictive	ADJ
admet-530	108	28	models	model	NOUN
admet-530	108	29	of	of	ADP
admet-530	108	30	each	each	DET
admet-530	108	31	descriptor	descriptor	NOUN
admet-530	108	32	(	(	PUNCT
admet-530	108	33	e.g.	e.g.	ADV
admet-530	108	34	figure	figure	NOUN
admet-530	108	35	8	8	NUM
admet-530	108	36	for	for	ADP
admet-530	108	37	chrom	chrom	PROPN
admet-530	108	38	log	log	NOUN
admet-530	108	39	d7.4	d7.4	PROPN
admet-530	108	40	)	)	PUNCT
admet-530	108	41	.	.	PUNCT
admet-530	109	1	good	good	ADJ
admet-530	109	2	practice	practice	NOUN
admet-530	109	3	exploits	exploit	VERB
admet-530	109	4	iterative	iterative	ADJ
admet-530	109	5	prediction	prediction	NOUN
admet-530	109	6	/	/	SYM
admet-530	109	7	measurement	measurement	NOUN
admet-530	109	8	cycles	cycle	NOUN
admet-530	109	9	to	to	PART
admet-530	109	10	build	build	VERB
admet-530	109	11	confidence	confidence	NOUN
admet-530	109	12	in	in	ADP
admet-530	109	13	each	each	DET
admet-530	109	14	series	series	NOUN
admet-530	109	15	under	under	ADP
admet-530	109	16	optimisation	optimisation	NOUN
admet-530	109	17	;	;	PUNCT
admet-530	109	18	this	this	PRON
admet-530	109	19	also	also	ADV
admet-530	109	20	enables	enable	VERB
admet-530	109	21	refinement	refinement	NOUN
admet-530	109	22	of	of	ADP
admet-530	109	23	models	model	NOUN
admet-530	109	24	on	on	ADP
admet-530	109	25	an	an	DET
admet-530	109	26	ad	ad	X
admet-530	109	27	hoc	hoc	X
admet-530	109	28	local	local	ADJ
admet-530	109	29	basis	basis	NOUN
admet-530	109	30	in	in	ADP
admet-530	109	31	the	the	DET
admet-530	109	32	rare	rare	ADJ
admet-530	109	33	cases	case	NOUN
admet-530	109	34	that	that	SCONJ
admet-530	109	35	the	the	DET
admet-530	109	36	global	global	ADJ
admet-530	109	37	model	model	NOUN
admet-530	109	38	does	do	AUX
admet-530	109	39	not	not	PART
admet-530	109	40	perform	perform	VERB
admet-530	109	41	well	well	ADV
admet-530	109	42	for	for	ADP
admet-530	109	43	a	a	DET
admet-530	109	44	given	give	VERB
admet-530	109	45	structural	structural	ADJ
admet-530	109	46	series	series	NOUN
admet-530	109	47	.	.	PUNCT
admet-530	110	1	the	the	DET
admet-530	110	2	next	next	ADJ
admet-530	110	3	level	level	NOUN
admet-530	110	4	is	be	AUX
admet-530	110	5	to	to	PART
admet-530	110	6	use	use	VERB
admet-530	110	7	these	these	DET
admet-530	110	8	predictions	prediction	NOUN
admet-530	110	9	as	as	ADP
admet-530	110	10	part	part	NOUN
admet-530	110	11	of	of	ADP
admet-530	110	12	multivariate	multivariate	NOUN
admet-530	110	13	and	and	CCONJ
admet-530	110	14	other	other	ADJ
admet-530	110	15	predictive	predictive	ADJ
admet-530	110	16	models	model	NOUN
admet-530	110	17	of	of	ADP
admet-530	110	18	various	various	ADJ
admet-530	110	19	dmpk	dmpk	NOUN
admet-530	110	20	parameters	parameter	NOUN
admet-530	110	21	(	(	PUNCT
admet-530	110	22	including	include	VERB
admet-530	110	23	drug	drug	NOUN
admet-530	110	24	efficiency	efficiency	NOUN
admet-530	110	25	)	)	PUNCT
admet-530	110	26	,	,	PUNCT
admet-530	110	27	which	which	PRON
admet-530	110	28	are	be	AUX
admet-530	110	29	demonstrably	demonstrably	ADV
admet-530	110	30	improved	improve	VERB
admet-530	110	31	by	by	ADP
admet-530	110	32	the	the	DET
admet-530	110	33	enhanced	enhance	VERB
admet-530	110	34	predictions	prediction	NOUN
admet-530	110	35	of	of	ADP
admet-530	110	36	physicochemical	physicochemical	ADJ
admet-530	110	37	descriptors	descriptor	NOUN
admet-530	110	38	.	.	PUNCT
admet-530	111	1	together	together	ADV
admet-530	111	2	,	,	PUNCT
admet-530	111	3	the	the	DET
admet-530	111	4	output	output	NOUN
admet-530	111	5	admet	admet	PROPN
admet-530	111	6	&	&	CCONJ
admet-530	111	7	dmpk	dmpk	PROPN
admet-530	111	8	6(2	6(2	NUM
admet-530	111	9	)	)	PUNCT
admet-530	111	10	(	(	PUNCT
admet-530	111	11	2018	2018	NUM
admet-530	111	12	)	)	PUNCT
admet-530	111	13	74	74	NUM
admet-530	111	14	-	-	SYM
admet-530	111	15	84	84	NUM
admet-530	111	16	high	high	ADJ
admet-530	111	17	throughput	throughput	NOUN
admet-530	111	18	biomimetic	biomimetic	ADJ
admet-530	111	19	measurements	measurement	NOUN
admet-530	111	20	in	in	ADP
admet-530	111	21	drug	drug	NOUN
admet-530	111	22	discovery	discovery	NOUN
admet-530	111	23	doi	doi	PROPN
admet-530	111	24	:	:	PUNCT
admet-530	111	25	10.5599	10.5599	NUM
admet-530	111	26	/	/	SYM
admet-530	111	27	admet.530	admet.530	PROPN
admet-530	111	28	81	81	NUM
admet-530	111	29	of	of	ADP
admet-530	111	30	these	these	DET
admet-530	111	31	initiatives	initiative	NOUN
admet-530	111	32	is	be	AUX
admet-530	111	33	enabling	enable	VERB
admet-530	111	34	an	an	DET
admet-530	111	35	aspiration	aspiration	NOUN
admet-530	111	36	to	to	PART
admet-530	111	37	predict	predict	VERB
admet-530	111	38	by	by	ADP
admet-530	111	39	first	first	ADJ
admet-530	111	40	intent	intent	NOUN
admet-530	111	41	in	in	ADP
admet-530	111	42	the	the	DET
admet-530	111	43	physicochemical	physicochemical	ADJ
admet-530	111	44	design	design	NOUN
admet-530	111	45	process	process	NOUN
admet-530	111	46	with	with	ADP
admet-530	111	47	demonstrable	demonstrable	ADJ
admet-530	111	48	impacts	impact	NOUN
admet-530	111	49	.	.	PUNCT
admet-530	112	1	figure	figure	NOUN
admet-530	112	2	7	7	NUM
admet-530	112	3	.	.	PUNCT
admet-530	112	4	plot	plot	NOUN
admet-530	112	5	of	of	ADP
admet-530	112	6	potency	potency	NOUN
admet-530	112	7	vs	vs	ADP
admet-530	112	8	log	log	NOUN
admet-530	112	9	(	(	PUNCT
admet-530	112	10	hplc	hplc	PROPN
admet-530	112	11	demax	demax	NOUN
admet-530	112	12	)	)	PUNCT
admet-530	112	13	values	value	NOUN
admet-530	112	14	for	for	ADP
admet-530	112	15	programme	programme	NOUN
admet-530	112	16	compounds	compound	NOUN
admet-530	112	17	(	(	PUNCT
admet-530	112	18	green	green	ADJ
admet-530	112	19	)	)	PUNCT
admet-530	112	20	overlaid	overlay	VERB
admet-530	112	21	with	with	ADP
admet-530	112	22	the	the	DET
admet-530	112	23	training	training	NOUN
admet-530	112	24	set	set	NOUN
admet-530	112	25	of	of	ADP
admet-530	112	26	known	know	VERB
admet-530	112	27	drugs	drug	NOUN
admet-530	112	28	blue	blue	ADJ
admet-530	112	29	,	,	PUNCT
admet-530	112	30	with	with	SCONJ
admet-530	112	31	the	the	DET
admet-530	112	32	candidates	candidate	NOUN
admet-530	112	33	are	be	AUX
admet-530	112	34	chosen	choose	VERB
admet-530	112	35	for	for	ADP
admet-530	112	36	progression	progression	NOUN
admet-530	112	37	in	in	ADP
admet-530	112	38	red	red	PROPN
admet-530	112	39	.	.	PUNCT
admet-530	113	1	figure	figure	NOUN
admet-530	113	2	8	8	NUM
admet-530	113	3	.	.	PUNCT
admet-530	114	1	trellised	trellis	VERB
admet-530	114	2	plot	plot	NOUN
admet-530	114	3	of	of	ADP
admet-530	114	4	calculated	calculate	VERB
admet-530	114	5	vs	vs	ADP
admet-530	114	6	measured	measure	VERB
admet-530	114	7	chrom	chrom	NOUN
admet-530	114	8	log	log	NOUN
admet-530	114	9	d7.4	d7.4	PROPN
admet-530	114	10	for	for	ADP
admet-530	114	11	compounds	compound	NOUN
admet-530	114	12	in	in	ADP
admet-530	114	13	6	6	NUM
admet-530	114	14	distinct	distinct	ADJ
admet-530	114	15	chemical	chemical	NOUN
admet-530	114	16	series	series	NOUN
admet-530	114	17	with	with	ADP
admet-530	114	18	lines	line	NOUN
admet-530	114	19	of	of	ADP
admet-530	114	20	best	good	ADJ
admet-530	114	21	fit	fit	ADJ
admet-530	114	22	and	and	CCONJ
admet-530	114	23	unity	unity	NOUN
admet-530	114	24	;	;	PUNCT
admet-530	114	25	the	the	DET
admet-530	114	26	r	r	NOUN
admet-530	114	27	2	2	NUM
admet-530	114	28	values	value	NOUN
admet-530	114	29	illustrate	illustrate	VERB
admet-530	114	30	the	the	DET
admet-530	114	31	quality	quality	NOUN
admet-530	114	32	of	of	ADP
admet-530	114	33	the	the	DET
admet-530	114	34	predictions	prediction	NOUN
admet-530	114	35	s.	s.	PROPN
admet-530	114	36	bunnally	bunnally	PROPN
admet-530	114	37	and	and	CCONJ
admet-530	114	38	r.j	r.j	PROPN
admet-530	114	39	.	.	PROPN
admet-530	114	40	young	young	ADJ
admet-530	114	41	admet	admet	PROPN
admet-530	114	42	&	&	CCONJ
admet-530	114	43	dmpk	dmpk	PROPN
admet-530	114	44	6(2	6(2	NUM
admet-530	114	45	)	)	PUNCT
admet-530	114	46	(	(	PUNCT
admet-530	114	47	2018	2018	NUM
admet-530	114	48	)	)	PUNCT
admet-530	114	49	74	74	NUM
admet-530	114	50	-	-	SYM
admet-530	114	51	84	84	NUM
admet-530	114	52	82	82	NUM
admet-530	114	53	conclusions	conclusion	NOUN
admet-530	114	54	the	the	DET
admet-530	114	55	extensive	extensive	ADJ
admet-530	114	56	use	use	NOUN
admet-530	114	57	of	of	ADP
admet-530	114	58	high	high	ADJ
admet-530	114	59	throughput	throughput	NOUN
admet-530	114	60	biomimetic	biomimetic	ADJ
admet-530	114	61	measurements	measurement	NOUN
admet-530	114	62	impacts	impact	NOUN
admet-530	114	63	on	on	ADP
admet-530	114	64	the	the	DET
admet-530	114	65	drug	drug	NOUN
admet-530	114	66	discovery	discovery	NOUN
admet-530	114	67	process	process	NOUN
admet-530	114	68	in	in	ADP
admet-530	114	69	many	many	ADJ
admet-530	114	70	ways	way	NOUN
admet-530	114	71	.	.	PUNCT
admet-530	115	1	chromatographic	chromatographic	ADJ
admet-530	115	2	lipophilicity	lipophilicity	NOUN
admet-530	115	3	measurements	measurement	NOUN
admet-530	115	4	are	be	AUX
admet-530	115	5	at	at	ADP
admet-530	115	6	the	the	DET
admet-530	115	7	core	core	NOUN
admet-530	115	8	of	of	ADP
admet-530	115	9	medicinal	medicinal	ADJ
admet-530	115	10	chemistry	chemistry	NOUN
admet-530	115	11	programmes	programme	NOUN
admet-530	115	12	and	and	CCONJ
admet-530	115	13	can	can	AUX
admet-530	115	14	be	be	AUX
admet-530	115	15	used	use	VERB
admet-530	115	16	to	to	PART
admet-530	115	17	predict	predict	VERB
admet-530	115	18	outcomes	outcome	NOUN
admet-530	115	19	,	,	PUNCT
admet-530	115	20	design	design	VERB
admet-530	115	21	better	well	ADJ
admet-530	115	22	compounds	compound	NOUN
admet-530	115	23	and	and	CCONJ
admet-530	115	24	as	as	ADP
admet-530	115	25	quality	quality	NOUN
admet-530	115	26	indicators	indicator	NOUN
admet-530	115	27	.	.	PUNCT
admet-530	116	1	the	the	DET
admet-530	116	2	complementary	complementary	ADJ
admet-530	116	3	measurements	measurement	NOUN
admet-530	116	4	from	from	ADP
admet-530	116	5	other	other	ADJ
admet-530	116	6	stationary	stationary	ADJ
admet-530	116	7	phases	phase	NOUN
admet-530	116	8	such	such	ADJ
admet-530	116	9	as	as	ADP
admet-530	116	10	hsa	hsa	PROPN
admet-530	116	11	and	and	CCONJ
admet-530	116	12	iam	iam	PROPN
admet-530	116	13	are	be	AUX
admet-530	116	14	now	now	ADV
admet-530	116	15	routinely	routinely	ADV
admet-530	116	16	used	use	VERB
admet-530	116	17	;	;	PUNCT
admet-530	116	18	increasing	increase	VERB
admet-530	116	19	awareness	awareness	NOUN
admet-530	116	20	with	with	ADP
admet-530	116	21	demonstrations	demonstration	NOUN
admet-530	116	22	of	of	ADP
admet-530	116	23	their	their	PRON
admet-530	116	24	utility	utility	NOUN
admet-530	116	25	and	and	CCONJ
admet-530	116	26	predictive	predictive	ADJ
admet-530	116	27	impact	impact	NOUN
admet-530	116	28	.	.	PUNCT
admet-530	117	1	this	this	PRON
admet-530	117	2	should	should	AUX
admet-530	117	3	give	give	VERB
admet-530	117	4	an	an	DET
admet-530	117	5	enhanced	enhanced	ADJ
admet-530	117	6	influence	influence	NOUN
admet-530	117	7	to	to	PART
admet-530	117	8	programme	programme	VERB
admet-530	117	9	progression	progression	NOUN
admet-530	117	10	in	in	ADP
admet-530	117	11	the	the	DET
admet-530	117	12	future	future	NOUN
admet-530	117	13	.	.	PUNCT
admet-530	118	1	acknowledgements	acknowledgement	NOUN
admet-530	118	2	:	:	PUNCT
admet-530	118	3	we	we	PRON
admet-530	118	4	gratefully	gratefully	ADV
admet-530	118	5	acknowledge	acknowledge	VERB
admet-530	118	6	the	the	DET
admet-530	118	7	contributions	contribution	NOUN
admet-530	118	8	of	of	ADP
admet-530	118	9	many	many	ADJ
admet-530	118	10	colleagues	colleague	NOUN
admet-530	118	11	in	in	ADP
admet-530	118	12	the	the	DET
admet-530	118	13	gsk	gsk	NOUN
admet-530	118	14	phys	phy	NOUN
admet-530	118	15	chem	chem	NOUN
admet-530	118	16	group	group	NOUN
admet-530	118	17	,	,	PUNCT
admet-530	118	18	present	present	ADJ
admet-530	118	19	and	and	CCONJ
admet-530	118	20	,	,	PUNCT
admet-530	118	21	largely	largely	ADV
admet-530	118	22	past	past	ADJ
admet-530	118	23	,	,	PUNCT
admet-530	118	24	notably	notably	ADV
admet-530	118	25	klara	klara	PROPN
admet-530	118	26	valko	valko	PROPN
admet-530	118	27	and	and	CCONJ
admet-530	118	28	alan	alan	PROPN
admet-530	118	29	hill	hill	PROPN
admet-530	118	30	,	,	PUNCT
admet-530	118	31	plus	plus	CCONJ
admet-530	118	32	many	many	ADJ
admet-530	118	33	colleagues	colleague	NOUN
admet-530	118	34	in	in	ADP
admet-530	118	35	computational	computational	ADJ
admet-530	118	36	and	and	CCONJ
admet-530	118	37	medicinal	medicinal	ADJ
admet-530	118	38	chemistry	chemistry	NOUN
admet-530	118	39	for	for	ADP
admet-530	118	40	model	model	NOUN
admet-530	118	41	development	development	NOUN
admet-530	118	42	and	and	CCONJ
admet-530	118	43	access	access	NOUN
admet-530	118	44	to	to	ADP
admet-530	118	45	data	datum	NOUN
admet-530	118	46	and	and	CCONJ
admet-530	118	47	examples	example	NOUN
admet-530	118	48	.	.	PUNCT
admet-530	119	1	references	reference	NOUN
admet-530	119	2	[	[	X
admet-530	119	3	1	1	NUM
admet-530	119	4	]	]	X
admet-530	119	5	r.j	r.j	PROPN
admet-530	119	6	.	.	PROPN
admet-530	119	7	young	young	ADJ
admet-530	119	8	,	,	PUNCT
admet-530	119	9	physical	physical	ADJ
admet-530	119	10	properties	property	NOUN
admet-530	119	11	in	in	ADP
admet-530	119	12	drug	drug	NOUN
admet-530	119	13	design	design	NOUN
admet-530	119	14	,	,	PUNCT
admet-530	119	15	in	in	ADP
admet-530	119	16	:	:	PUNCT
admet-530	119	17	n.a	n.a	PROPN
admet-530	119	18	.	.	PROPN
admet-530	119	19	meanwell	meanwell	PROPN
admet-530	119	20	(	(	PUNCT
admet-530	119	21	ed	ed	NOUN
admet-530	119	22	.	.	PUNCT
admet-530	119	23	)	)	PUNCT
admet-530	119	24	tactics	tactic	NOUN
admet-530	119	25	in	in	ADP
admet-530	119	26	contemporary	contemporary	ADJ
admet-530	119	27	drug	drug	NOUN
admet-530	119	28	design	design	NOUN
admet-530	119	29	,	,	PUNCT
admet-530	119	30	springer	springer	NOUN
admet-530	119	31	berlin	berlin	PROPN
admet-530	119	32	heidelberg	heidelberg	PROPN
admet-530	119	33	,	,	PUNCT
admet-530	119	34	berlin	berlin	PROPN
admet-530	119	35	,	,	PUNCT
admet-530	119	36	heidelberg	heidelberg	PROPN
admet-530	119	37	,	,	PUNCT
admet-530	119	38	2014	2014	NUM
admet-530	119	39	,	,	PUNCT
admet-530	119	40	pp	pp	ADJ
admet-530	119	41	.	.	PUNCT
admet-530	120	1	1	1	NUM
admet-530	120	2	-	-	SYM
admet-530	120	3	68	68	NUM
admet-530	120	4	.	.	PUNCT
admet-530	121	1	[	[	X
admet-530	121	2	2	2	X
admet-530	121	3	]	]	X
admet-530	121	4	n.a	n.a	PROPN
admet-530	121	5	.	.	PROPN
admet-530	121	6	meanwell	meanwell	PROPN
admet-530	121	7	.	.	PUNCT
admet-530	122	1	improving	improve	VERB
admet-530	122	2	drug	drug	NOUN
admet-530	122	3	candidates	candidate	NOUN
admet-530	122	4	by	by	ADP
admet-530	122	5	design	design	NOUN
admet-530	122	6	:	:	PUNCT
admet-530	122	7	a	a	DET
admet-530	122	8	focus	focus	NOUN
admet-530	122	9	on	on	ADP
admet-530	122	10	physicochemical	physicochemical	ADJ
admet-530	122	11	properties	property	NOUN
admet-530	122	12	as	as	ADP
admet-530	122	13	a	a	DET
admet-530	122	14	means	means	NOUN
admet-530	122	15	of	of	ADP
admet-530	122	16	improving	improve	VERB
admet-530	122	17	compound	compound	NOUN
admet-530	122	18	disposition	disposition	NOUN
admet-530	122	19	and	and	CCONJ
admet-530	122	20	safety	safety	NOUN
admet-530	122	21	.	.	PUNCT
admet-530	123	1	chemical	chemical	ADJ
admet-530	123	2	research	research	NOUN
admet-530	123	3	in	in	ADP
admet-530	123	4	toxicology	toxicology	NOUN
admet-530	123	5	24	24	NUM
admet-530	123	6	(	(	PUNCT
admet-530	123	7	2011	2011	NUM
admet-530	123	8	)	)	PUNCT
admet-530	123	9	1420	1420	NUM
admet-530	123	10	-	-	SYM
admet-530	123	11	1456	1456	NUM
admet-530	123	12	.	.	PUNCT
admet-530	124	1	[	[	X
admet-530	124	2	3	3	X
admet-530	124	3	]	]	X
admet-530	124	4	m.p	m.p	PROPN
admet-530	124	5	.	.	PROPN
admet-530	124	6	gleeson	gleeson	PROPN
admet-530	124	7	,	,	PUNCT
admet-530	124	8	p.d	p.d	PROPN
admet-530	124	9	.	.	PROPN
admet-530	124	10	leeson	leeson	PROPN
admet-530	124	11	,	,	PUNCT
admet-530	124	12	h.van	h.van	PROPN
admet-530	124	13	der	der	ADJ
admet-530	124	14	waterbeemd	waterbeemd	PROPN
admet-530	124	15	,	,	PUNCT
admet-530	124	16	chapter	chapter	NOUN
admet-530	124	17	1	1	NUM
admet-530	124	18	.	.	PUNCT
admet-530	124	19	physicochemical	physicochemical	ADJ
admet-530	124	20	properties	property	NOUN
admet-530	124	21	and	and	CCONJ
admet-530	124	22	compound	compound	NOUN
admet-530	124	23	quality	quality	NOUN
admet-530	124	24	,	,	PUNCT
admet-530	124	25	the	the	DET
admet-530	124	26	handbook	handbook	NOUN
admet-530	124	27	of	of	ADP
admet-530	124	28	medicinal	medicinal	ADJ
admet-530	124	29	chemistry	chemistry	NOUN
admet-530	124	30	,	,	PUNCT
admet-530	124	31	the	the	DET
admet-530	124	32	royal	royal	ADJ
admet-530	124	33	society	society	NOUN
admet-530	124	34	of	of	ADP
admet-530	124	35	chemistry2015	chemistry2015	PROPN
admet-530	124	36	,	,	PUNCT
admet-530	124	37	pp	pp	X
admet-530	124	38	.	.	PUNCT
admet-530	125	1	1	1	NUM
admet-530	125	2	-	-	SYM
admet-530	125	3	31	31	NUM
admet-530	125	4	.	.	PUNCT
admet-530	126	1	[	[	X
admet-530	126	2	4	4	NUM
admet-530	126	3	]	]	X
admet-530	126	4	p.d	p.d	PROPN
admet-530	126	5	.	.	PROPN
admet-530	126	6	leeson	leeson	PROPN
admet-530	126	7	,	,	PUNCT
admet-530	126	8	b.	b.	PROPN
admet-530	126	9	springthorpe	springthorpe	PROPN
admet-530	126	10	.	.	PUNCT
admet-530	127	1	the	the	DET
admet-530	127	2	influence	influence	NOUN
admet-530	127	3	of	of	ADP
admet-530	127	4	drug	drug	NOUN
admet-530	127	5	-	-	PUNCT
admet-530	127	6	like	like	ADJ
admet-530	127	7	concepts	concept	NOUN
admet-530	127	8	on	on	ADP
admet-530	127	9	decision	decision	NOUN
admet-530	127	10	-	-	PUNCT
admet-530	127	11	making	making	NOUN
admet-530	127	12	in	in	ADP
admet-530	127	13	medicinal	medicinal	ADJ
admet-530	127	14	chemistry	chemistry	NOUN
admet-530	127	15	.	.	PUNCT
admet-530	128	1	nat	nat	PROPN
admet-530	128	2	rev	rev	PROPN
admet-530	128	3	drug	drug	PROPN
admet-530	128	4	discov	discov	PROPN
admet-530	128	5	6	6	NUM
admet-530	128	6	(	(	PUNCT
admet-530	128	7	2007	2007	NUM
admet-530	128	8	)	)	PUNCT
admet-530	128	9	881	881	NUM
admet-530	128	10	-	-	SYM
admet-530	128	11	890	890	NUM
admet-530	128	12	.	.	PUNCT
admet-530	129	1	[	[	X
admet-530	129	2	5	5	NUM
admet-530	129	3	]	]	X
admet-530	129	4	p.d	p.d	PROPN
admet-530	129	5	.	.	PROPN
admet-530	129	6	leeson	leeson	PROPN
admet-530	129	7	,	,	PUNCT
admet-530	129	8	r.j	r.j	PROPN
admet-530	129	9	.	.	PROPN
admet-530	129	10	young	young	PROPN
admet-530	129	11	.	.	PUNCT
admet-530	130	1	molecular	molecular	ADJ
admet-530	130	2	property	property	NOUN
admet-530	130	3	design	design	NOUN
admet-530	130	4	:	:	PUNCT
admet-530	130	5	does	do	AUX
admet-530	130	6	everyone	everyone	PRON
admet-530	130	7	get	get	VERB
admet-530	130	8	it	it	PRON
admet-530	130	9	?	?	PUNCT
admet-530	131	1	acs	acs	PROPN
admet-530	131	2	medicinal	medicinal	ADJ
admet-530	131	3	chemistry	chemistry	NOUN
admet-530	131	4	letters	letter	NOUN
admet-530	131	5	6	6	NUM
admet-530	131	6	(	(	PUNCT
admet-530	131	7	2015	2015	NUM
admet-530	131	8	)	)	PUNCT
admet-530	131	9	722	722	NUM
admet-530	131	10	-	-	SYM
admet-530	131	11	725	725	NUM
admet-530	131	12	.	.	PUNCT
admet-530	132	1	[	[	X
admet-530	132	2	6	6	NUM
admet-530	132	3	]	]	X
admet-530	132	4	m.p	m.p	PROPN
admet-530	132	5	.	.	PROPN
admet-530	132	6	gleeson	gleeson	PROPN
admet-530	132	7	,	,	PUNCT
admet-530	132	8	a.	a.	PROPN
admet-530	132	9	hersey	hersey	PROPN
admet-530	132	10	,	,	PUNCT
admet-530	132	11	d.	d.	PROPN
admet-530	132	12	montanari	montanari	PROPN
admet-530	132	13	,	,	PUNCT
admet-530	132	14	j.	j.	PROPN
admet-530	132	15	overington	overington	PROPN
admet-530	132	16	.	.	PUNCT
admet-530	133	1	probing	probe	VERB
admet-530	133	2	the	the	DET
admet-530	133	3	links	link	NOUN
admet-530	133	4	between	between	ADP
admet-530	133	5	in	in	ADP
admet-530	133	6	vitro	vitro	X
admet-530	133	7	potency	potency	NOUN
admet-530	133	8	,	,	PUNCT
admet-530	133	9	admet	admet	PROPN
admet-530	133	10	and	and	CCONJ
admet-530	133	11	physicochemical	physicochemical	ADJ
admet-530	133	12	parameters	parameter	NOUN
admet-530	133	13	.	.	PUNCT
admet-530	134	1	nat	nat	PROPN
admet-530	134	2	rev	rev	VERB
admet-530	134	3	drug	drug	PROPN
admet-530	134	4	discov	discov	PROPN
admet-530	134	5	10	10	NUM
admet-530	134	6	(	(	PUNCT
admet-530	134	7	2011	2011	NUM
admet-530	134	8	)	)	PUNCT
admet-530	134	9	197	197	NUM
admet-530	134	10	-	-	SYM
admet-530	134	11	208	208	NUM
admet-530	134	12	.	.	PUNCT
admet-530	135	1	[	[	X
admet-530	135	2	7	7	NUM
admet-530	135	3	]	]	X
admet-530	135	4	r.j	r.j	PROPN
admet-530	135	5	.	.	PROPN
admet-530	135	6	young	young	PROPN
admet-530	135	7	,	,	PUNCT
admet-530	135	8	p.d	p.d	PROPN
admet-530	135	9	.	.	PROPN
admet-530	135	10	leeson	leeson	PROPN
admet-530	135	11	.	.	PUNCT
admet-530	136	1	mapping	map	VERB
admet-530	136	2	the	the	DET
admet-530	136	3	efficiency	efficiency	NOUN
admet-530	136	4	and	and	CCONJ
admet-530	136	5	physicochemical	physicochemical	ADJ
admet-530	136	6	trajectories	trajectory	NOUN
admet-530	136	7	of	of	ADP
admet-530	136	8	successful	successful	ADJ
admet-530	136	9	optimizations	optimization	NOUN
admet-530	136	10	.	.	PUNCT
admet-530	137	1	journal	journal	NOUN
admet-530	137	2	of	of	ADP
admet-530	137	3	medicinal	medicinal	ADJ
admet-530	137	4	chemistry	chemistry	NOUN
admet-530	137	5	in	in	ADP
admet-530	137	6	press	press	NOUN
admet-530	137	7	(	(	PUNCT
admet-530	137	8	2018	2018	NUM
admet-530	137	9	)	)	PUNCT
admet-530	137	10	.	.	PUNCT
admet-530	138	1	[	[	X
admet-530	138	2	8	8	NUM
admet-530	138	3	]	]	X
admet-530	138	4	a.p	a.p	PROPN
admet-530	138	5	.	.	PROPN
admet-530	138	6	hill	hill	PROPN
admet-530	138	7	,	,	PUNCT
admet-530	138	8	r.j	r.j	PROPN
admet-530	138	9	.	.	PROPN
admet-530	138	10	young	young	PROPN
admet-530	138	11	.	.	PUNCT
admet-530	139	1	getting	get	VERB
admet-530	139	2	physical	physical	ADJ
admet-530	139	3	in	in	ADP
admet-530	139	4	drug	drug	NOUN
admet-530	139	5	discovery	discovery	NOUN
admet-530	139	6	:	:	PUNCT
admet-530	139	7	a	a	DET
admet-530	139	8	contemporary	contemporary	ADJ
admet-530	139	9	perspective	perspective	NOUN
admet-530	139	10	on	on	ADP
admet-530	139	11	solubility	solubility	NOUN
admet-530	139	12	and	and	CCONJ
admet-530	139	13	hydrophobicity	hydrophobicity	NOUN
admet-530	139	14	.	.	PUNCT
admet-530	140	1	drug	drug	NOUN
admet-530	140	2	discov	discov	PROPN
admet-530	140	3	today	today	NOUN
admet-530	140	4	15	15	NUM
admet-530	140	5	(	(	PUNCT
admet-530	140	6	2010	2010	NUM
admet-530	140	7	)	)	PUNCT
admet-530	140	8	648	648	NUM
admet-530	140	9	-	-	SYM
admet-530	140	10	655	655	NUM
admet-530	140	11	.	.	PUNCT
admet-530	141	1	[	[	X
admet-530	141	2	9	9	NUM
admet-530	141	3	]	]	PUNCT
admet-530	141	4	k.	k.	PROPN
admet-530	141	5	valko	valko	PROPN
admet-530	141	6	,	,	PUNCT
admet-530	141	7	c.	c.	PROPN
admet-530	141	8	bevan	bevan	PROPN
admet-530	141	9	,	,	PUNCT
admet-530	141	10	d.	d.	PROPN
admet-530	141	11	reynolds	reynolds	PROPN
admet-530	141	12	.	.	PUNCT
admet-530	141	13	chromatographic	chromatographic	ADJ
admet-530	141	14	hydrophobicity	hydrophobicity	NOUN
admet-530	141	15	index	index	NOUN
admet-530	141	16	by	by	ADP
admet-530	141	17	fast	fast	ADJ
admet-530	141	18	-	-	PUNCT
admet-530	141	19	gradient	gradient	NOUN
admet-530	141	20	rp	rp	NOUN
admet-530	141	21	-	-	PUNCT
admet-530	141	22	hplc	hplc	NOUN
admet-530	141	23	:	:	PUNCT
admet-530	141	24	a	a	DET
admet-530	141	25	high	high	ADJ
admet-530	141	26	-	-	PUNCT
admet-530	141	27	throughput	throughput	NOUN
admet-530	141	28	alternative	alternative	NOUN
admet-530	141	29	to	to	PART
admet-530	141	30	log	log	VERB
admet-530	141	31	p	p	NOUN
admet-530	141	32	/	/	SYM
admet-530	141	33	log	log	NOUN
admet-530	141	34	d.	d.	PROPN
admet-530	141	35	analytical	analytical	ADJ
admet-530	141	36	chemistry	chemistry	NOUN
admet-530	141	37	69	69	NUM
admet-530	141	38	(	(	PUNCT
admet-530	141	39	1997	1997	NUM
admet-530	141	40	)	)	PUNCT
admet-530	141	41	2022	2022	NUM
admet-530	141	42	-	-	SYM
admet-530	141	43	2029	2029	NUM
admet-530	141	44	.	.	PUNCT
admet-530	142	1	[	[	X
admet-530	142	2	10	10	NUM
admet-530	142	3	]	]	X
admet-530	142	4	r.j	r.j	PROPN
admet-530	142	5	.	.	PROPN
admet-530	142	6	young	young	PROPN
admet-530	142	7	,	,	PUNCT
admet-530	142	8	d.v	d.v	PROPN
admet-530	142	9	.	.	PROPN
admet-530	142	10	green	green	PROPN
admet-530	142	11	,	,	PUNCT
admet-530	142	12	c.n	c.n	PROPN
admet-530	142	13	.	.	PROPN
admet-530	142	14	luscombe	luscombe	PROPN
admet-530	142	15	,	,	PUNCT
admet-530	142	16	a.p	a.p	PROPN
admet-530	142	17	.	.	PROPN
admet-530	142	18	hill	hill	PROPN
admet-530	142	19	.	.	PUNCT
admet-530	143	1	getting	get	VERB
admet-530	143	2	physical	physical	ADJ
admet-530	143	3	in	in	ADP
admet-530	143	4	drug	drug	PROPN
admet-530	143	5	discovery	discovery	PROPN
admet-530	143	6	ii	ii	PROPN
admet-530	143	7	:	:	PUNCT
admet-530	143	8	the	the	DET
admet-530	143	9	impact	impact	NOUN
admet-530	143	10	of	of	ADP
admet-530	143	11	chromatographic	chromatographic	ADJ
admet-530	143	12	hydrophobicity	hydrophobicity	NOUN
admet-530	143	13	measurements	measurement	NOUN
admet-530	143	14	and	and	CCONJ
admet-530	143	15	aromaticity	aromaticity	NOUN
admet-530	143	16	.	.	PUNCT
admet-530	144	1	drug	drug	NOUN
admet-530	144	2	discov	discov	PROPN
admet-530	144	3	today	today	NOUN
admet-530	144	4	16	16	NUM
admet-530	144	5	(	(	PUNCT
admet-530	144	6	2011	2011	NUM
admet-530	144	7	)	)	PUNCT
admet-530	144	8	822830	822830	NUM
admet-530	144	9	.	.	PUNCT
admet-530	145	1	[	[	X
admet-530	145	2	11	11	NUM
admet-530	145	3	]	]	X
admet-530	145	4	g.	g.	PROPN
admet-530	145	5	caron	caron	PROPN
admet-530	145	6	,	,	PUNCT
admet-530	145	7	m.	m.	NOUN
admet-530	145	8	vallaro	vallaro	NOUN
admet-530	145	9	,	,	PUNCT
admet-530	145	10	g.	g.	PROPN
admet-530	145	11	ermondi	ermondi	PROPN
admet-530	145	12	,	,	PUNCT
admet-530	145	13	g.h	g.h	PROPN
admet-530	145	14	.	.	PROPN
admet-530	145	15	goetz	goetz	PROPN
admet-530	145	16	,	,	PUNCT
admet-530	145	17	y.a	y.a	PROPN
admet-530	145	18	.	.	PROPN
admet-530	145	19	abramov	abramov	PROPN
admet-530	145	20	,	,	PUNCT
admet-530	145	21	l.	l.	PROPN
admet-530	145	22	philippe	philippe	PROPN
admet-530	145	23	,	,	PUNCT
admet-530	145	24	m.	m.	NOUN
admet-530	145	25	shalaeva	shalaeva	PROPN
admet-530	145	26	.	.	PUNCT
admet-530	146	1	a	a	DET
admet-530	146	2	fast	fast	ADJ
admet-530	146	3	chromatographic	chromatographic	ADJ
admet-530	146	4	method	method	NOUN
admet-530	146	5	for	for	ADP
admet-530	146	6	estimating	estimate	VERB
admet-530	146	7	lipophilicity	lipophilicity	NOUN
admet-530	146	8	and	and	CCONJ
admet-530	146	9	ionization	ionization	NOUN
admet-530	146	10	in	in	ADP
admet-530	146	11	nonpolar	nonpolar	ADJ
admet-530	146	12	membrane	membrane	NOUN
admet-530	146	13	-	-	PUNCT
admet-530	146	14	like	like	ADJ
admet-530	146	15	environment	environment	NOUN
admet-530	146	16	.	.	PUNCT
admet-530	147	1	molecular	molecular	ADJ
admet-530	147	2	pharmaceutics	pharmaceutic	NOUN
admet-530	147	3	13	13	NUM
admet-530	147	4	(	(	PUNCT
admet-530	147	5	2016	2016	NUM
admet-530	147	6	)	)	PUNCT
admet-530	147	7	1100	1100	NUM
admet-530	147	8	-	-	SYM
admet-530	147	9	1110	1110	NUM
admet-530	147	10	.	.	PUNCT
admet-530	148	1	[	[	X
admet-530	148	2	12	12	NUM
admet-530	148	3	]	]	X
admet-530	148	4	k.l	k.l	PROPN
admet-530	148	5	.	.	PROPN
admet-530	148	6	valkó	valkó	PROPN
admet-530	148	7	.	.	PUNCT
admet-530	149	1	lipophilicity	lipophilicity	NOUN
admet-530	149	2	and	and	CCONJ
admet-530	149	3	biomimetic	biomimetic	ADJ
admet-530	149	4	properties	property	NOUN
admet-530	149	5	measured	measure	VERB
admet-530	149	6	by	by	ADP
admet-530	149	7	hplc	hplc	NOUN
admet-530	149	8	to	to	PART
admet-530	149	9	support	support	VERB
admet-530	149	10	drug	drug	NOUN
admet-530	149	11	discovery	discovery	NOUN
admet-530	149	12	.	.	PUNCT
admet-530	150	1	journal	journal	PROPN
admet-530	150	2	of	of	ADP
admet-530	150	3	pharmaceutical	pharmaceutical	NOUN
admet-530	150	4	and	and	CCONJ
admet-530	150	5	biomedical	biomedical	ADJ
admet-530	150	6	analysis	analysis	NOUN
admet-530	150	7	130	130	NUM
admet-530	150	8	(	(	PUNCT
admet-530	150	9	2016	2016	NUM
admet-530	150	10	)	)	PUNCT
admet-530	150	11	35	35	NUM
admet-530	150	12	-	-	SYM
admet-530	150	13	54	54	NUM
admet-530	150	14	.	.	PUNCT
admet-530	151	1	[	[	X
admet-530	151	2	13	13	NUM
admet-530	151	3	]	]	X
admet-530	151	4	m.k	m.k	PROPN
admet-530	151	5	.	.	PROPN
admet-530	151	6	bayliss	bayliss	PROPN
admet-530	151	7	,	,	PUNCT
admet-530	151	8	j.	j.	PROPN
admet-530	151	9	butler	butler	PROPN
admet-530	151	10	,	,	PUNCT
admet-530	151	11	p.l	p.l	PROPN
admet-530	151	12	.	.	PROPN
admet-530	151	13	feldman	feldman	PROPN
admet-530	151	14	,	,	PUNCT
admet-530	151	15	d.v	d.v	PROPN
admet-530	151	16	.	.	PROPN
admet-530	151	17	green	green	PROPN
admet-530	151	18	,	,	PUNCT
admet-530	151	19	p.d	p.d	PROPN
admet-530	151	20	.	.	PROPN
admet-530	151	21	leeson	leeson	PROPN
admet-530	151	22	,	,	PUNCT
admet-530	151	23	m.r	m.r	PROPN
admet-530	151	24	.	.	PROPN
admet-530	151	25	palovich	palovich	PROPN
admet-530	151	26	,	,	PUNCT
admet-530	151	27	a.j	a.j	PROPN
admet-530	151	28	.	.	PROPN
admet-530	151	29	taylor	taylor	PROPN
admet-530	151	30	.	.	PUNCT
admet-530	152	1	quality	quality	NOUN
admet-530	152	2	guidelines	guideline	NOUN
admet-530	152	3	for	for	ADP
admet-530	152	4	oral	oral	ADJ
admet-530	152	5	drug	drug	NOUN
admet-530	152	6	candidates	candidate	NOUN
admet-530	152	7	:	:	PUNCT
admet-530	152	8	dose	dose	NOUN
admet-530	152	9	,	,	PUNCT
admet-530	152	10	solubility	solubility	NOUN
admet-530	152	11	and	and	CCONJ
admet-530	152	12	lipophilicity	lipophilicity	NOUN
admet-530	152	13	.	.	PUNCT
admet-530	153	1	drug	drug	NOUN
admet-530	153	2	discov	discov	PROPN
admet-530	153	3	today	today	NOUN
admet-530	153	4	21	21	NUM
admet-530	153	5	(	(	PUNCT
admet-530	153	6	2016	2016	NUM
admet-530	153	7	)	)	PUNCT
admet-530	153	8	1719	1719	NUM
admet-530	153	9	-	-	SYM
admet-530	153	10	1727	1727	NUM
admet-530	153	11	.	.	PUNCT
admet-530	154	1	[	[	X
admet-530	154	2	14	14	NUM
admet-530	154	3	]	]	X
admet-530	154	4	c.	c.	PROPN
admet-530	154	5	horváth	horváth	PROPN
admet-530	154	6	,	,	PUNCT
admet-530	154	7	w.	w.	NOUN
admet-530	154	8	melander	melander	NOUN
admet-530	154	9	,	,	PUNCT
admet-530	154	10	i.	i.	PROPN
admet-530	154	11	molnár	molnár	PROPN
admet-530	154	12	.	.	PUNCT
admet-530	155	1	solvophobic	solvophobic	ADJ
admet-530	155	2	interactions	interaction	NOUN
admet-530	155	3	in	in	ADP
admet-530	155	4	liquid	liquid	ADJ
admet-530	155	5	chromatography	chromatography	NOUN
admet-530	155	6	with	with	ADP
admet-530	155	7	nonpolar	nonpolar	ADJ
admet-530	155	8	stationary	stationary	ADJ
admet-530	155	9	phases	phase	NOUN
admet-530	155	10	.	.	PUNCT
admet-530	156	1	journal	journal	NOUN
admet-530	156	2	of	of	ADP
admet-530	156	3	chromatography	chromatography	NOUN
admet-530	156	4	a	a	DET
admet-530	156	5	125	125	NUM
admet-530	156	6	(	(	PUNCT
admet-530	156	7	1976	1976	NUM
admet-530	156	8	)	)	PUNCT
admet-530	156	9	129	129	NUM
admet-530	156	10	-	-	SYM
admet-530	156	11	156	156	NUM
admet-530	156	12	.	.	PUNCT
admet-530	157	1	admet	admet	PROPN
admet-530	157	2	&	&	CCONJ
admet-530	157	3	dmpk	dmpk	PROPN
admet-530	157	4	6(2	6(2	NUM
admet-530	157	5	)	)	PUNCT
admet-530	157	6	(	(	PUNCT
admet-530	157	7	2018	2018	NUM
admet-530	157	8	)	)	PUNCT
admet-530	157	9	74	74	NUM
admet-530	157	10	-	-	SYM
admet-530	157	11	84	84	NUM
admet-530	157	12	high	high	ADJ
admet-530	157	13	throughput	throughput	NOUN
admet-530	157	14	biomimetic	biomimetic	ADJ
admet-530	157	15	measurements	measurement	NOUN
admet-530	157	16	in	in	ADP
admet-530	157	17	drug	drug	NOUN
admet-530	157	18	discovery	discovery	NOUN
admet-530	157	19	doi	doi	PROPN
admet-530	157	20	:	:	PUNCT
admet-530	157	21	10.5599	10.5599	NUM
admet-530	157	22	/	/	SYM
admet-530	157	23	admet.530	admet.530	VERB
admet-530	157	24	83	83	NUM
admet-530	158	1	[	[	X
admet-530	158	2	15	15	NUM
admet-530	158	3	]	]	X
admet-530	158	4	f.	f.	PROPN
admet-530	158	5	lombardo	lombardo	PROPN
admet-530	158	6	,	,	PUNCT
admet-530	158	7	m.y	m.y	PROPN
admet-530	158	8	.	.	PROPN
admet-530	158	9	shalaeva	shalaeva	PROPN
admet-530	158	10	,	,	PUNCT
admet-530	158	11	k.a	k.a	PROPN
admet-530	158	12	.	.	PROPN
admet-530	158	13	tupper	tupper	PROPN
admet-530	158	14	,	,	PUNCT
admet-530	158	15	f.	f.	PROPN
admet-530	158	16	gao	gao	PROPN
admet-530	158	17	.	.	PUNCT
admet-530	159	1	elogdoct	elogdoct	PROPN
admet-530	159	2	:	:	PUNCT
admet-530	159	3	  	  	SPACE
admet-530	159	4	a	a	DET
admet-530	159	5	tool	tool	NOUN
admet-530	159	6	for	for	ADP
admet-530	159	7	lipophilicity	lipophilicity	NOUN
admet-530	159	8	determination	determination	NOUN
admet-530	159	9	in	in	ADP
admet-530	159	10	drug	drug	NOUN
admet-530	159	11	discovery	discovery	NOUN
admet-530	159	12	.	.	PUNCT
admet-530	160	1	2	2	X
admet-530	160	2	.	.	NUM
admet-530	160	3	basic	basic	ADJ
admet-530	160	4	and	and	CCONJ
admet-530	160	5	neutral	neutral	ADJ
admet-530	160	6	compounds	compound	NOUN
admet-530	160	7	.	.	PUNCT
admet-530	161	1	journal	journal	NOUN
admet-530	161	2	of	of	ADP
admet-530	161	3	medicinal	medicinal	ADJ
admet-530	161	4	chemistry	chemistry	NOUN
admet-530	161	5	44	44	NUM
admet-530	161	6	(	(	PUNCT
admet-530	161	7	2001	2001	NUM
admet-530	161	8	)	)	PUNCT
admet-530	161	9	24902497	24902497	NUM
admet-530	161	10	.	.	PUNCT
admet-530	162	1	[	[	X
admet-530	162	2	16	16	NUM
admet-530	162	3	]	]	PUNCT
admet-530	162	4	a.	a.	NOUN
admet-530	162	5	vailaya	vailaya	PROPN
admet-530	162	6	,	,	PUNCT
admet-530	162	7	c.	c.	PROPN
admet-530	162	8	horváth	horváth	PROPN
admet-530	162	9	.	.	PUNCT
admet-530	163	1	solvophobic	solvophobic	ADJ
admet-530	163	2	theory	theory	NOUN
admet-530	163	3	and	and	CCONJ
admet-530	163	4	normalized	normalize	VERB
admet-530	163	5	free	free	ADJ
admet-530	163	6	energies	energy	NOUN
admet-530	163	7	of	of	ADP
admet-530	163	8	nonpolar	nonpolar	ADJ
admet-530	163	9	substances	substance	NOUN
admet-530	163	10	in	in	ADP
admet-530	163	11	reversed	reverse	VERB
admet-530	163	12	phase	phase	NOUN
admet-530	163	13	chromatography	chromatography	NOUN
admet-530	163	14	.	.	PUNCT
admet-530	164	1	the	the	DET
admet-530	164	2	journal	journal	NOUN
admet-530	164	3	of	of	ADP
admet-530	164	4	physical	physical	ADJ
admet-530	164	5	chemistry	chemistry	NOUN
admet-530	164	6	b	b	PROPN
admet-530	164	7	101	101	NUM
admet-530	164	8	(	(	PUNCT
admet-530	164	9	1997	1997	NUM
admet-530	164	10	)	)	PUNCT
admet-530	164	11	5875	5875	NUM
admet-530	164	12	-	-	SYM
admet-530	164	13	5888	5888	NUM
admet-530	164	14	.	.	PUNCT
admet-530	165	1	[	[	X
admet-530	165	2	17	17	NUM
admet-530	165	3	]	]	PUNCT
admet-530	165	4	k.	k.	PROPN
admet-530	165	5	valkó	valkó	PROPN
admet-530	165	6	,	,	PUNCT
admet-530	165	7	l.r	l.r	PROPN
admet-530	165	8	.	.	PROPN
admet-530	165	9	snyder	snyder	PROPN
admet-530	165	10	,	,	PUNCT
admet-530	165	11	j.l	j.l	PROPN
admet-530	165	12	.	.	PROPN
admet-530	165	13	glajch	glajch	PROPN
admet-530	165	14	.	.	PUNCT
admet-530	166	1	retention	retention	NOUN
admet-530	166	2	in	in	ADP
admet-530	166	3	reversed	reverse	VERB
admet-530	166	4	-	-	PUNCT
admet-530	166	5	phase	phase	NOUN
admet-530	166	6	liquid	liquid	ADJ
admet-530	166	7	chromatography	chromatography	NOUN
admet-530	166	8	as	as	ADP
admet-530	166	9	a	a	DET
admet-530	166	10	function	function	NOUN
admet-530	166	11	of	of	ADP
admet-530	166	12	mobile	mobile	ADJ
admet-530	166	13	-	-	PUNCT
admet-530	166	14	phase	phase	NOUN
admet-530	166	15	composition	composition	NOUN
admet-530	166	16	.	.	PUNCT
admet-530	167	1	journal	journal	PROPN
admet-530	167	2	of	of	ADP
admet-530	167	3	chromatography	chromatography	NOUN
admet-530	167	4	a	a	DET
admet-530	167	5	656	656	NUM
admet-530	167	6	(	(	PUNCT
admet-530	167	7	1993	1993	NUM
admet-530	167	8	)	)	PUNCT
admet-530	167	9	501	501	NUM
admet-530	167	10	-	-	SYM
admet-530	167	11	520	520	NUM
admet-530	167	12	.	.	PUNCT
admet-530	168	1	[	[	X
admet-530	168	2	18	18	NUM
admet-530	168	3	]	]	X
admet-530	168	4	m.j	m.j	PROPN
admet-530	168	5	.	.	PROPN
admet-530	168	6	waring	waring	NOUN
admet-530	168	7	.	.	PUNCT
admet-530	169	1	lipophilicity	lipophilicity	NOUN
admet-530	169	2	in	in	ADP
admet-530	169	3	drug	drug	NOUN
admet-530	169	4	discovery	discovery	NOUN
admet-530	169	5	.	.	PUNCT
admet-530	170	1	expert	expert	NOUN
admet-530	170	2	opin	opin	NOUN
admet-530	170	3	drug	drug	NOUN
admet-530	170	4	discov	discov	NOUN
admet-530	170	5	5	5	NUM
admet-530	170	6	(	(	PUNCT
admet-530	170	7	2010	2010	NUM
admet-530	170	8	)	)	PUNCT
admet-530	170	9	235	235	NUM
admet-530	170	10	-	-	SYM
admet-530	170	11	248	248	NUM
admet-530	170	12	.	.	PUNCT
admet-530	171	1	[	[	X
admet-530	171	2	19	19	NUM
admet-530	171	3	]	]	X
admet-530	171	4	c.	c.	PROPN
admet-530	171	5	hansch	hansch	PROPN
admet-530	171	6	,	,	PUNCT
admet-530	171	7	j.p	j.p	PROPN
admet-530	171	8	.	.	PROPN
admet-530	171	9	bjorkroth	bjorkroth	PROPN
admet-530	171	10	,	,	PUNCT
admet-530	171	11	a.	a.	PROPN
admet-530	171	12	leo	leo	PROPN
admet-530	171	13	.	.	PROPN
admet-530	171	14	hydrophobicity	hydrophobicity	PROPN
admet-530	171	15	and	and	CCONJ
admet-530	171	16	central	central	ADJ
admet-530	171	17	nervous	nervous	ADJ
admet-530	171	18	system	system	NOUN
admet-530	171	19	agents	agent	NOUN
admet-530	171	20	:	:	PUNCT
admet-530	171	21	on	on	ADP
admet-530	171	22	the	the	DET
admet-530	171	23	principle	principle	NOUN
admet-530	171	24	of	of	ADP
admet-530	171	25	minimal	minimal	ADJ
admet-530	171	26	hydrophobicity	hydrophobicity	NOUN
admet-530	171	27	in	in	ADP
admet-530	171	28	drug	drug	NOUN
admet-530	171	29	design	design	NOUN
admet-530	171	30	.	.	PUNCT
admet-530	172	1	journal	journal	NOUN
admet-530	172	2	of	of	ADP
admet-530	172	3	pharmaceutical	pharmaceutical	PROPN
admet-530	172	4	sciences	science	NOUN
admet-530	172	5	76	76	NUM
admet-530	172	6	(	(	PUNCT
admet-530	172	7	1987	1987	NUM
admet-530	172	8	)	)	PUNCT
admet-530	172	9	663	663	NUM
admet-530	172	10	-	-	SYM
admet-530	172	11	687	687	NUM
admet-530	172	12	.	.	PUNCT
admet-530	173	1	[	[	X
admet-530	173	2	20	20	NUM
admet-530	173	3	]	]	X
admet-530	173	4	a.l	a.l	PROPN
admet-530	173	5	.	.	PROPN
admet-530	173	6	hopkins	hopkins	PROPN
admet-530	173	7	,	,	PUNCT
admet-530	173	8	g.m	g.m	PROPN
admet-530	173	9	.	.	PROPN
admet-530	173	10	keseru	keseru	PROPN
admet-530	173	11	,	,	PUNCT
admet-530	173	12	p.d	p.d	PROPN
admet-530	173	13	.	.	PROPN
admet-530	173	14	leeson	leeson	PROPN
admet-530	173	15	,	,	PUNCT
admet-530	173	16	d.c	d.c	PROPN
admet-530	173	17	.	.	PROPN
admet-530	173	18	rees	rees	PROPN
admet-530	173	19	,	,	PUNCT
admet-530	173	20	c.h	c.h	PROPN
admet-530	173	21	.	.	PROPN
admet-530	173	22	reynolds	reynolds	PROPN
admet-530	173	23	.	.	PUNCT
admet-530	174	1	the	the	DET
admet-530	174	2	role	role	NOUN
admet-530	174	3	of	of	ADP
admet-530	174	4	ligand	ligand	ADJ
admet-530	174	5	efficiency	efficiency	NOUN
admet-530	174	6	metrics	metric	NOUN
admet-530	174	7	in	in	ADP
admet-530	174	8	drug	drug	NOUN
admet-530	174	9	discovery	discovery	NOUN
admet-530	174	10	.	.	PUNCT
admet-530	175	1	nat	nat	PROPN
admet-530	175	2	rev	rev	PROPN
admet-530	175	3	drug	drug	PROPN
admet-530	175	4	discov	discov	PROPN
admet-530	175	5	13	13	NUM
admet-530	175	6	(	(	PUNCT
admet-530	175	7	2014	2014	NUM
admet-530	175	8	)	)	PUNCT
admet-530	175	9	105	105	NUM
admet-530	175	10	-	-	SYM
admet-530	175	11	121	121	NUM
admet-530	175	12	.	.	PUNCT
admet-530	176	1	[	[	X
admet-530	176	2	21	21	NUM
admet-530	176	3	]	]	X
admet-530	176	4	t.j	t.j	PROPN
admet-530	176	5	.	.	PROPN
admet-530	176	6	ritchie	ritchie	PROPN
admet-530	176	7	,	,	PUNCT
admet-530	176	8	s.j	s.j	PROPN
admet-530	176	9	.	.	PROPN
admet-530	176	10	macdonald	macdonald	PROPN
admet-530	176	11	.	.	PUNCT
admet-530	177	1	physicochemical	physicochemical	ADJ
admet-530	177	2	descriptors	descriptor	NOUN
admet-530	177	3	of	of	ADP
admet-530	177	4	aromatic	aromatic	ADJ
admet-530	177	5	character	character	NOUN
admet-530	177	6	and	and	CCONJ
admet-530	177	7	their	their	PRON
admet-530	177	8	use	use	NOUN
admet-530	177	9	in	in	ADP
admet-530	177	10	drug	drug	NOUN
admet-530	177	11	discovery	discovery	NOUN
admet-530	177	12	.	.	PUNCT
admet-530	178	1	journal	journal	PROPN
admet-530	178	2	of	of	ADP
admet-530	178	3	medicinal	medicinal	ADJ
admet-530	178	4	chemistry	chemistry	NOUN
admet-530	178	5	57	57	NUM
admet-530	178	6	(	(	PUNCT
admet-530	178	7	2014	2014	NUM
admet-530	178	8	)	)	PUNCT
admet-530	178	9	7206	7206	NUM
admet-530	178	10	-	-	SYM
admet-530	178	11	7215	7215	NUM
admet-530	178	12	.	.	PUNCT
admet-530	179	1	[	[	X
admet-530	179	2	22	22	NUM
admet-530	179	3	]	]	X
admet-530	179	4	t.j	t.j	PROPN
admet-530	179	5	.	.	PROPN
admet-530	179	6	ritchie	ritchie	PROPN
admet-530	179	7	,	,	PUNCT
admet-530	179	8	s.j	s.j	PROPN
admet-530	179	9	.	.	PROPN
admet-530	179	10	macdonald	macdonald	PROPN
admet-530	179	11	.	.	PUNCT
admet-530	180	1	the	the	DET
admet-530	180	2	impact	impact	NOUN
admet-530	180	3	of	of	ADP
admet-530	180	4	aromatic	aromatic	ADJ
admet-530	180	5	ring	ring	NOUN
admet-530	180	6	count	count	NOUN
admet-530	180	7	on	on	ADP
admet-530	180	8	compound	compound	NOUN
admet-530	180	9	developability	developability	NOUN
admet-530	180	10	--	--	PUNCT
admet-530	180	11	are	be	AUX
admet-530	180	12	too	too	ADV
admet-530	180	13	many	many	ADJ
admet-530	180	14	aromatic	aromatic	ADJ
admet-530	180	15	rings	ring	NOUN
admet-530	180	16	a	a	DET
admet-530	180	17	liability	liability	NOUN
admet-530	180	18	in	in	ADP
admet-530	180	19	drug	drug	NOUN
admet-530	180	20	design	design	NOUN
admet-530	180	21	?	?	PUNCT
admet-530	181	1	drug	drug	NOUN
admet-530	181	2	discov	discov	NOUN
admet-530	181	3	today	today	NOUN
admet-530	181	4	14	14	NUM
admet-530	181	5	(	(	PUNCT
admet-530	181	6	2009	2009	NUM
admet-530	181	7	)	)	PUNCT
admet-530	181	8	1011	1011	NUM
admet-530	181	9	-	-	SYM
admet-530	181	10	1020	1020	NUM
admet-530	181	11	.	.	PUNCT
admet-530	182	1	[	[	X
admet-530	182	2	23	23	NUM
admet-530	182	3	]	]	X
admet-530	182	4	t.j	t.j	PROPN
admet-530	182	5	.	.	PROPN
admet-530	182	6	ritchie	ritchie	PROPN
admet-530	182	7	,	,	PUNCT
admet-530	182	8	s.j	s.j	PROPN
admet-530	182	9	.	.	PROPN
admet-530	182	10	macdonald	macdonald	PROPN
admet-530	182	11	,	,	PUNCT
admet-530	182	12	r.j	r.j	PROPN
admet-530	182	13	.	.	PROPN
admet-530	182	14	young	young	PROPN
admet-530	182	15	,	,	PUNCT
admet-530	182	16	s.d	s.d	PROPN
admet-530	182	17	.	.	PROPN
admet-530	182	18	pickett	pickett	PROPN
admet-530	182	19	.	.	PUNCT
admet-530	183	1	the	the	DET
admet-530	183	2	impact	impact	NOUN
admet-530	183	3	of	of	ADP
admet-530	183	4	aromatic	aromatic	ADJ
admet-530	183	5	ring	ring	NOUN
admet-530	183	6	count	count	NOUN
admet-530	183	7	on	on	ADP
admet-530	183	8	compound	compound	NOUN
admet-530	183	9	developability	developability	NOUN
admet-530	183	10	:	:	PUNCT
admet-530	183	11	further	further	ADJ
admet-530	183	12	insights	insight	NOUN
admet-530	183	13	by	by	ADP
admet-530	183	14	examining	examine	VERB
admet-530	183	15	carboand	carboand	NOUN
admet-530	183	16	hetero	hetero	NOUN
admet-530	183	17	-	-	PUNCT
admet-530	183	18	aromatic	aromatic	ADJ
admet-530	183	19	and	and	CCONJ
admet-530	183	20	-aliphatic	-aliphatic	ADJ
admet-530	183	21	ring	ring	NOUN
admet-530	183	22	types	type	NOUN
admet-530	183	23	.	.	PUNCT
admet-530	184	1	drug	drug	NOUN
admet-530	184	2	discov	discov	PROPN
admet-530	184	3	today	today	NOUN
admet-530	184	4	16	16	NUM
admet-530	184	5	(	(	PUNCT
admet-530	184	6	2011	2011	NUM
admet-530	184	7	)	)	PUNCT
admet-530	184	8	164	164	NUM
admet-530	184	9	-	-	SYM
admet-530	184	10	171	171	NUM
admet-530	184	11	.	.	PUNCT
admet-530	185	1	[	[	X
admet-530	185	2	24	24	NUM
admet-530	185	3	]	]	PUNCT
admet-530	185	4	k.	k.	PROPN
admet-530	185	5	valko	valko	PROPN
admet-530	185	6	,	,	PUNCT
admet-530	185	7	s.	s.	PROPN
admet-530	185	8	nunhuck	nunhuck	PROPN
admet-530	185	9	,	,	PUNCT
admet-530	185	10	c.	c.	PROPN
admet-530	185	11	bevan	bevan	PROPN
admet-530	185	12	,	,	PUNCT
admet-530	185	13	m.h	m.h	PROPN
admet-530	185	14	.	.	PROPN
admet-530	185	15	abraham	abraham	PROPN
admet-530	185	16	,	,	PUNCT
admet-530	185	17	d.p	d.p	PROPN
admet-530	185	18	.	.	PROPN
admet-530	185	19	reynolds	reynolds	PROPN
admet-530	185	20	.	.	PUNCT
admet-530	186	1	fast	fast	ADJ
admet-530	186	2	gradient	gradient	NOUN
admet-530	186	3	hplc	hplc	NOUN
admet-530	186	4	method	method	NOUN
admet-530	186	5	to	to	PART
admet-530	186	6	determine	determine	VERB
admet-530	186	7	compounds	compound	NOUN
admet-530	186	8	binding	bind	VERB
admet-530	186	9	to	to	ADP
admet-530	186	10	human	human	ADJ
admet-530	186	11	serum	serum	NOUN
admet-530	186	12	albumin	albumin	NOUN
admet-530	186	13	.	.	PUNCT
admet-530	187	1	relationships	relationship	NOUN
admet-530	187	2	with	with	ADP
admet-530	187	3	octanol	octanol	NOUN
admet-530	187	4	/	/	SYM
admet-530	187	5	water	water	NOUN
admet-530	187	6	and	and	CCONJ
admet-530	187	7	immobilized	immobilize	VERB
admet-530	187	8	artificial	artificial	ADJ
admet-530	187	9	membrane	membrane	NOUN
admet-530	187	10	lipophilicity	lipophilicity	NOUN
admet-530	187	11	.	.	PUNCT
admet-530	188	1	journal	journal	NOUN
admet-530	188	2	of	of	ADP
admet-530	188	3	pharmaceutical	pharmaceutical	PROPN
admet-530	188	4	sciences	science	NOUN
admet-530	188	5	92	92	NUM
admet-530	188	6	(	(	PUNCT
admet-530	188	7	2003	2003	NUM
admet-530	188	8	)	)	PUNCT
admet-530	188	9	22362248	22362248	NUM
admet-530	188	10	.	.	PUNCT
admet-530	189	1	[	[	X
admet-530	189	2	25	25	NUM
admet-530	189	3	]	]	PUNCT
admet-530	189	4	c.	c.	NOUN
admet-530	189	5	pidgeon	pidgeon	PROPN
admet-530	189	6	,	,	PUNCT
admet-530	189	7	s.	s.	PROPN
admet-530	189	8	ong	ong	PROPN
admet-530	189	9	,	,	PUNCT
admet-530	189	10	h.	h.	PROPN
admet-530	189	11	liu	liu	PROPN
admet-530	189	12	,	,	PUNCT
admet-530	189	13	x.	x.	PROPN
admet-530	189	14	qiu	qiu	PROPN
admet-530	189	15	,	,	PUNCT
admet-530	189	16	m.	m.	NOUN
admet-530	189	17	pidgeon	pidgeon	NOUN
admet-530	189	18	,	,	PUNCT
admet-530	189	19	a.h	a.h	PROPN
admet-530	189	20	.	.	PROPN
admet-530	189	21	dantzig	dantzig	PROPN
admet-530	189	22	,	,	PUNCT
admet-530	189	23	j.	j.	PROPN
admet-530	189	24	munroe	munroe	PROPN
admet-530	189	25	,	,	PUNCT
admet-530	189	26	w.j	w.j	PROPN
admet-530	189	27	.	.	PROPN
admet-530	189	28	hornback	hornback	PROPN
admet-530	189	29	,	,	PUNCT
admet-530	189	30	j.s	j.s	PROPN
admet-530	189	31	.	.	PUNCT
admet-530	189	32	kasher	kasher	PROPN
admet-530	189	33	.	.	PUNCT
admet-530	190	1	iam	iam	PROPN
admet-530	190	2	chromatography	chromatography	NOUN
admet-530	190	3	:	:	PUNCT
admet-530	190	4	an	an	DET
admet-530	190	5	in	in	ADP
admet-530	190	6	vitro	vitro	X
admet-530	190	7	screen	screen	NOUN
admet-530	190	8	for	for	ADP
admet-530	190	9	predicting	predict	VERB
admet-530	190	10	drug	drug	NOUN
admet-530	190	11	membrane	membrane	NOUN
admet-530	190	12	permeability	permeability	NOUN
admet-530	190	13	.	.	PUNCT
admet-530	191	1	journal	journal	NOUN
admet-530	191	2	of	of	ADP
admet-530	191	3	medicinal	medicinal	ADJ
admet-530	191	4	chemistry	chemistry	NOUN
admet-530	191	5	38	38	NUM
admet-530	191	6	(	(	PUNCT
admet-530	191	7	1995	1995	NUM
admet-530	191	8	)	)	PUNCT
admet-530	191	9	590	590	NUM
admet-530	191	10	-	-	SYM
admet-530	191	11	594	594	NUM
admet-530	191	12	.	.	PUNCT
admet-530	192	1	[	[	X
admet-530	192	2	26	26	NUM
admet-530	192	3	]	]	PUNCT
admet-530	192	4	k.	k.	PROPN
admet-530	192	5	valko	valko	PROPN
admet-530	192	6	,	,	PUNCT
admet-530	192	7	c.m	c.m	PROPN
admet-530	192	8	.	.	PROPN
admet-530	192	9	du	du	PROPN
admet-530	192	10	,	,	PUNCT
admet-530	192	11	c.d	c.d	PROPN
admet-530	192	12	.	.	PROPN
admet-530	192	13	bevan	bevan	PROPN
admet-530	192	14	,	,	PUNCT
admet-530	192	15	d.p	d.p	PROPN
admet-530	192	16	.	.	PROPN
admet-530	192	17	reynolds	reynolds	PROPN
admet-530	192	18	,	,	PUNCT
admet-530	192	19	m.h	m.h	PROPN
admet-530	192	20	.	.	PROPN
admet-530	192	21	abraham	abraham	PROPN
admet-530	192	22	.	.	PUNCT
admet-530	193	1	rapid	rapid	ADJ
admet-530	193	2	-	-	PUNCT
admet-530	193	3	gradient	gradient	NOUN
admet-530	193	4	hplc	hplc	NOUN
admet-530	193	5	method	method	NOUN
admet-530	193	6	for	for	ADP
admet-530	193	7	measuring	measure	VERB
admet-530	193	8	drug	drug	NOUN
admet-530	193	9	interactions	interaction	NOUN
admet-530	193	10	with	with	ADP
admet-530	193	11	immobilized	immobilized	ADJ
admet-530	193	12	artificial	artificial	ADJ
admet-530	193	13	membrane	membrane	NOUN
admet-530	193	14	:	:	PUNCT
admet-530	193	15	comparison	comparison	NOUN
admet-530	193	16	with	with	ADP
admet-530	193	17	other	other	ADJ
admet-530	193	18	lipophilicity	lipophilicity	NOUN
admet-530	193	19	measures	measure	NOUN
admet-530	193	20	.	.	PUNCT
admet-530	194	1	journal	journal	NOUN
admet-530	194	2	of	of	ADP
admet-530	194	3	pharmaceutical	pharmaceutical	PROPN
admet-530	194	4	sciences	science	NOUN
admet-530	194	5	89	89	NUM
admet-530	194	6	(	(	PUNCT
admet-530	194	7	2000	2000	NUM
admet-530	194	8	)	)	PUNCT
admet-530	194	9	1085	1085	NUM
admet-530	194	10	-	-	SYM
admet-530	194	11	1096	1096	NUM
admet-530	194	12	.	.	PUNCT
admet-530	195	1	[	[	X
admet-530	195	2	27	27	NUM
admet-530	195	3	]	]	X
admet-530	195	4	f.	f.	PROPN
admet-530	195	5	tsopelas	tsopelas	PROPN
admet-530	195	6	,	,	PUNCT
admet-530	195	7	t.	t.	PROPN
admet-530	195	8	vallianatou	vallianatou	PROPN
admet-530	195	9	,	,	PUNCT
admet-530	195	10	a.	a.	NOUN
admet-530	195	11	tsantili	tsantili	NOUN
admet-530	195	12	-	-	PUNCT
admet-530	195	13	kakoulidou	kakoulidou	NOUN
admet-530	195	14	.	.	PUNCT
admet-530	196	1	advances	advance	NOUN
admet-530	196	2	in	in	ADP
admet-530	196	3	immobilized	immobilized	ADJ
admet-530	196	4	artificial	artificial	ADJ
admet-530	196	5	membrane	membrane	NOUN
admet-530	196	6	(	(	PUNCT
admet-530	196	7	iam	iam	PROPN
admet-530	196	8	)	)	PUNCT
admet-530	196	9	chromatography	chromatography	NOUN
admet-530	196	10	for	for	ADP
admet-530	196	11	novel	novel	ADJ
admet-530	196	12	drug	drug	NOUN
admet-530	196	13	discovery	discovery	NOUN
admet-530	196	14	.	.	PUNCT
admet-530	197	1	expert	expert	ADJ
admet-530	197	2	opinion	opinion	NOUN
admet-530	197	3	on	on	ADP
admet-530	197	4	drug	drug	NOUN
admet-530	197	5	discovery	discovery	NOUN
admet-530	197	6	11	11	NUM
admet-530	197	7	(	(	PUNCT
admet-530	197	8	2016	2016	NUM
admet-530	197	9	)	)	PUNCT
admet-530	197	10	473488	473488	NUM
admet-530	197	11	.	.	PUNCT
admet-530	198	1	[	[	X
admet-530	198	2	28	28	NUM
admet-530	198	3	]	]	X
admet-530	198	4	j.-m	j.-m	NOUN
admet-530	198	5	.	.	PUNCT
admet-530	199	1	alakoskela	alakoskela	PROPN
admet-530	199	2	,	,	PUNCT
admet-530	199	3	p.	p.	PROPN
admet-530	199	4	vitovič	vitovič	PROPN
admet-530	199	5	,	,	PUNCT
admet-530	199	6	p.k.j	p.k.j	PROPN
admet-530	199	7	.	.	PUNCT
admet-530	200	1	kinnunen	kinnunen	PROPN
admet-530	200	2	.	.	PUNCT
admet-530	201	1	screening	screen	VERB
admet-530	201	2	for	for	ADP
admet-530	201	3	the	the	DET
admet-530	201	4	drug	drug	NOUN
admet-530	201	5	–	–	PUNCT
admet-530	201	6	phospholipid	phospholipid	NOUN
admet-530	201	7	interaction	interaction	NOUN
admet-530	201	8	:	:	PUNCT
admet-530	201	9	correlation	correlation	NOUN
admet-530	201	10	to	to	ADP
admet-530	201	11	phospholipidosis	phospholipidosis	NOUN
admet-530	201	12	.	.	PUNCT
admet-530	202	1	chemmedchem	chemmedchem	PROPN
admet-530	202	2	4	4	NUM
admet-530	202	3	(	(	PUNCT
admet-530	202	4	2009	2009	NUM
admet-530	202	5	)	)	PUNCT
admet-530	202	6	1224	1224	NUM
admet-530	202	7	-	-	SYM
admet-530	202	8	1251	1251	NUM
admet-530	202	9	.	.	PUNCT
admet-530	203	1	[	[	X
admet-530	203	2	29	29	NUM
admet-530	203	3	]	]	X
admet-530	203	4	n.	n.	PROPN
admet-530	203	5	anderson	anderson	PROPN
admet-530	203	6	,	,	PUNCT
admet-530	203	7	j.	j.	PROPN
admet-530	203	8	borlak	borlak	PROPN
admet-530	203	9	.	.	PUNCT
admet-530	204	1	drug	drug	NOUN
admet-530	204	2	-	-	PUNCT
admet-530	204	3	induced	induce	VERB
admet-530	204	4	phospholipidosis	phospholipidosis	NOUN
admet-530	204	5	.	.	PUNCT
admet-530	205	1	febs	febs	NOUN
admet-530	205	2	letters	letter	NOUN
admet-530	205	3	580	580	NUM
admet-530	205	4	(	(	PUNCT
admet-530	205	5	2006	2006	NUM
admet-530	205	6	)	)	PUNCT
admet-530	205	7	5533	5533	NUM
admet-530	205	8	-	-	SYM
admet-530	205	9	5540	5540	NUM
admet-530	205	10	.	.	PUNCT
admet-530	206	1	[	[	X
admet-530	206	2	30	30	NUM
admet-530	206	3	]	]	X
admet-530	206	4	s.	s.	PROPN
admet-530	206	5	braggio	braggio	PROPN
admet-530	206	6	,	,	PUNCT
admet-530	206	7	d.	d.	PROPN
admet-530	206	8	montanari	montanari	PROPN
admet-530	206	9	,	,	PUNCT
admet-530	206	10	t.	t.	PROPN
admet-530	206	11	rossi	rossi	PROPN
admet-530	206	12	,	,	PUNCT
admet-530	207	1	e.	e.	PROPN
admet-530	207	2	ratti	ratti	PROPN
admet-530	207	3	.	.	PUNCT
admet-530	207	4	drug	drug	NOUN
admet-530	207	5	efficiency	efficiency	NOUN
admet-530	207	6	:	:	PUNCT
admet-530	207	7	a	a	DET
admet-530	207	8	new	new	ADJ
admet-530	207	9	concept	concept	NOUN
admet-530	207	10	to	to	PART
admet-530	207	11	guide	guide	VERB
admet-530	207	12	lead	lead	ADJ
admet-530	207	13	optimization	optimization	NOUN
admet-530	207	14	programs	program	NOUN
admet-530	207	15	towards	towards	ADP
admet-530	207	16	the	the	DET
admet-530	207	17	selection	selection	NOUN
admet-530	207	18	of	of	ADP
admet-530	207	19	better	well	ADJ
admet-530	207	20	clinical	clinical	ADJ
admet-530	207	21	candidates	candidate	NOUN
admet-530	207	22	.	.	PUNCT
admet-530	208	1	expert	expert	ADJ
admet-530	208	2	opinion	opinion	NOUN
admet-530	208	3	on	on	ADP
admet-530	208	4	drug	drug	NOUN
admet-530	208	5	discovery	discovery	NOUN
admet-530	208	6	5	5	NUM
admet-530	208	7	(	(	PUNCT
admet-530	208	8	2010	2010	NUM
admet-530	208	9	)	)	PUNCT
admet-530	208	10	609	609	NUM
admet-530	208	11	-	-	SYM
admet-530	208	12	618	618	NUM
admet-530	208	13	.	.	PUNCT
admet-530	209	1	[	[	X
admet-530	209	2	31	31	NUM
admet-530	209	3	]	]	X
admet-530	209	4	k.l	k.l	PROPN
admet-530	209	5	.	.	PROPN
admet-530	209	6	valkó	valkó	PROPN
admet-530	209	7	,	,	PUNCT
admet-530	209	8	s.b	s.b	PROPN
admet-530	209	9	.	.	PROPN
admet-530	209	10	nunhuck	nunhuck	PROPN
admet-530	209	11	,	,	PUNCT
admet-530	209	12	a.p	a.p	PROPN
admet-530	209	13	.	.	PROPN
admet-530	209	14	hill	hill	PROPN
admet-530	209	15	.	.	PUNCT
admet-530	210	1	estimating	estimate	VERB
admet-530	210	2	unbound	unbound	NOUN
admet-530	210	3	volume	volume	NOUN
admet-530	210	4	of	of	ADP
admet-530	210	5	distribution	distribution	NOUN
admet-530	210	6	and	and	CCONJ
admet-530	210	7	tissue	tissue	NOUN
admet-530	210	8	binding	bind	VERB
admet-530	210	9	by	by	ADP
admet-530	210	10	in	in	ADP
admet-530	210	11	vitro	vitro	X
admet-530	210	12	hplc	hplc	NOUN
admet-530	210	13	-	-	PUNCT
admet-530	210	14	based	base	VERB
admet-530	210	15	human	human	ADJ
admet-530	210	16	serum	serum	NOUN
admet-530	210	17	albumin	albumin	NOUN
admet-530	210	18	and	and	CCONJ
admet-530	210	19	immobilised	immobilise	VERB
admet-530	210	20	artificial	artificial	ADJ
admet-530	210	21	membrane	membrane	NOUN
admet-530	210	22	-	-	PUNCT
admet-530	210	23	binding	bind	VERB
admet-530	210	24	measurements	measurement	NOUN
admet-530	210	25	.	.	PUNCT
admet-530	211	1	journal	journal	NOUN
admet-530	211	2	of	of	ADP
admet-530	211	3	pharmaceutical	pharmaceutical	PROPN
admet-530	211	4	sciences	science	NOUN
admet-530	211	5	100	100	NUM
admet-530	211	6	(	(	PUNCT
admet-530	211	7	2011	2011	NUM
admet-530	211	8	)	)	PUNCT
admet-530	211	9	849	849	NUM
admet-530	211	10	-	-	SYM
admet-530	211	11	862	862	NUM
admet-530	211	12	.	.	PUNCT
admet-530	212	1	[	[	X
admet-530	212	2	32	32	NUM
admet-530	212	3	]	]	PUNCT
admet-530	212	4	k.	k.	PROPN
admet-530	212	5	valko	valko	PROPN
admet-530	212	6	,	,	PUNCT
admet-530	212	7	e.	e.	PROPN
admet-530	212	8	chiarparin	chiarparin	PROPN
admet-530	212	9	,	,	PUNCT
admet-530	212	10	s.	s.	PROPN
admet-530	212	11	nunhuck	nunhuck	PROPN
admet-530	212	12	,	,	PUNCT
admet-530	212	13	d.	d.	PROPN
admet-530	212	14	montanari	montanari	PROPN
admet-530	212	15	.	.	PUNCT
admet-530	213	1	in	in	ADP
admet-530	213	2	vitro	vitro	X
admet-530	213	3	measurement	measurement	NOUN
admet-530	213	4	of	of	ADP
admet-530	213	5	drug	drug	NOUN
admet-530	213	6	efficiency	efficiency	NOUN
admet-530	213	7	index	index	NOUN
admet-530	213	8	to	to	PART
admet-530	213	9	aid	aid	VERB
admet-530	213	10	early	early	ADJ
admet-530	213	11	lead	lead	ADJ
admet-530	213	12	optimization	optimization	NOUN
admet-530	213	13	.	.	PUNCT
admet-530	214	1	journal	journal	PROPN
admet-530	214	2	of	of	ADP
admet-530	214	3	pharmaceutical	pharmaceutical	PROPN
admet-530	214	4	sciences	science	NOUN
admet-530	214	5	101	101	NUM
admet-530	214	6	(	(	PUNCT
admet-530	214	7	2012	2012	NUM
admet-530	214	8	)	)	PUNCT
admet-530	214	9	4155	4155	NUM
admet-530	214	10	-	-	SYM
admet-530	214	11	4169	4169	NUM
admet-530	214	12	.	.	PUNCT
admet-530	215	1	[	[	X
admet-530	215	2	33	33	NUM
admet-530	215	3	]	]	X
admet-530	215	4	k.l	k.l	PROPN
admet-530	215	5	.	.	PROPN
admet-530	215	6	valko	valko	PROPN
admet-530	215	7	,	,	PUNCT
admet-530	215	8	s.p	s.p	PROPN
admet-530	215	9	.	.	PROPN
admet-530	215	10	teague	teague	PROPN
admet-530	215	11	,	,	PUNCT
admet-530	215	12	c.	c.	PROPN
admet-530	215	13	pidgeon	pidgeon	PROPN
admet-530	215	14	.	.	PUNCT
admet-530	216	1	in	in	ADP
admet-530	216	2	vitro	vitro	X
admet-530	216	3	membrane	membrane	NOUN
admet-530	216	4	binding	bind	VERB
admet-530	216	5	and	and	CCONJ
admet-530	216	6	protein	protein	NOUN
admet-530	216	7	binding	bind	VERB
admet-530	216	8	(	(	PUNCT
admet-530	216	9	iam	iam	PROPN
admet-530	216	10	mb	mb	PROPN
admet-530	216	11	/	/	SYM
admet-530	216	12	pb	pb	X
admet-530	216	13	technology	technology	NOUN
admet-530	216	14	)	)	PUNCT
admet-530	216	15	to	to	PART
admet-530	216	16	estimate	estimate	VERB
admet-530	216	17	in	in	ADP
admet-530	216	18	vivo	vivo	ADJ
admet-530	216	19	distribution	distribution	NOUN
admet-530	216	20	:	:	PUNCT
admet-530	216	21	applications	application	NOUN
admet-530	216	22	in	in	ADP
admet-530	216	23	early	early	ADJ
admet-530	216	24	drug	drug	NOUN
admet-530	216	25	discovery	discovery	NOUN
admet-530	216	26	.	.	PUNCT
admet-530	217	1	admet	admet	PROPN
admet-530	217	2	and	and	CCONJ
admet-530	217	3	dmpk	dmpk	X
admet-530	217	4	5	5	NUM
admet-530	217	5	(	(	PUNCT
admet-530	217	6	2017	2017	NUM
admet-530	217	7	)	)	PUNCT
admet-530	217	8	14	14	NUM
admet-530	217	9	-	-	SYM
admet-530	217	10	38	38	NUM
admet-530	217	11	.	.	PUNCT
admet-530	218	1	s.	s.	PROPN
admet-530	218	2	bunnally	bunnally	PROPN
admet-530	218	3	and	and	CCONJ
admet-530	218	4	r.j	r.j	PROPN
admet-530	218	5	.	.	PROPN
admet-530	218	6	young	young	ADJ
admet-530	218	7	admet	admet	PROPN
admet-530	218	8	&	&	CCONJ
admet-530	218	9	dmpk	dmpk	PROPN
admet-530	218	10	6(2	6(2	NUM
admet-530	218	11	)	)	PUNCT
admet-530	218	12	(	(	PUNCT
admet-530	218	13	2018	2018	NUM
admet-530	218	14	)	)	PUNCT
admet-530	218	15	74	74	NUM
admet-530	218	16	-	-	SYM
admet-530	218	17	84	84	NUM
admet-530	218	18	84	84	NUM
admet-530	218	19	[	[	X
admet-530	218	20	34	34	NUM
admet-530	218	21	]	]	X
admet-530	218	22	s.	s.	PROPN
admet-530	218	23	teague	teague	PROPN
admet-530	218	24	,	,	PUNCT
admet-530	218	25	k.	k.	PROPN
admet-530	218	26	valko	valko	PROPN
admet-530	218	27	.	.	PUNCT
admet-530	219	1	how	how	SCONJ
admet-530	219	2	to	to	PART
admet-530	219	3	identify	identify	VERB
admet-530	219	4	and	and	CCONJ
admet-530	219	5	eliminate	eliminate	VERB
admet-530	219	6	compounds	compound	NOUN
admet-530	219	7	with	with	ADP
admet-530	219	8	a	a	DET
admet-530	219	9	risk	risk	NOUN
admet-530	219	10	of	of	ADP
admet-530	219	11	high	high	ADJ
admet-530	219	12	clinical	clinical	ADJ
admet-530	219	13	dose	dose	NOUN
admet-530	219	14	during	during	ADP
admet-530	219	15	the	the	DET
admet-530	219	16	early	early	ADJ
admet-530	219	17	phase	phase	NOUN
admet-530	219	18	of	of	ADP
admet-530	219	19	lead	lead	ADJ
admet-530	219	20	optimisation	optimisation	NOUN
admet-530	219	21	in	in	ADP
admet-530	219	22	drug	drug	NOUN
admet-530	219	23	discovery	discovery	NOUN
admet-530	219	24	.	.	PUNCT
admet-530	220	1	european	european	PROPN
admet-530	220	2	journal	journal	PROPN
admet-530	220	3	of	of	ADP
admet-530	220	4	pharmaceutical	pharmaceutical	PROPN
admet-530	220	5	sciences	science	NOUN
admet-530	220	6	110	110	NUM
admet-530	220	7	(	(	PUNCT
admet-530	220	8	2017	2017	NUM
admet-530	220	9	)	)	PUNCT
admet-530	220	10	37	37	NUM
admet-530	220	11	-	-	SYM
admet-530	220	12	50	50	NUM
admet-530	220	13	.	.	PUNCT
admet-530	221	1	©	©	PROPN
admet-530	221	2	2018	2018	NUM
admet-530	221	3	by	by	ADP
admet-530	221	4	the	the	DET
admet-530	221	5	authors	author	NOUN
admet-530	221	6	;	;	PUNCT
admet-530	222	1	licensee	licensee	PROPN
admet-530	222	2	iapc	iapc	PROPN
admet-530	222	3	,	,	PUNCT
admet-530	222	4	zagreb	zagreb	PROPN
admet-530	222	5	,	,	PUNCT
admet-530	222	6	croatia	croatia	PROPN
admet-530	222	7	.	.	PUNCT
admet-530	223	1	this	this	DET
admet-530	223	2	article	article	NOUN
admet-530	223	3	is	be	AUX
admet-530	223	4	an	an	DET
admet-530	223	5	open	open	ADJ
admet-530	223	6	-	-	PUNCT
admet-530	223	7	access	access	NOUN
admet-530	223	8	article	article	NOUN
admet-530	223	9	distributed	distribute	VERB
admet-530	223	10	under	under	ADP
admet-530	223	11	the	the	DET
admet-530	223	12	terms	term	NOUN
admet-530	223	13	and	and	CCONJ
admet-530	223	14	conditions	condition	NOUN
admet-530	223	15	of	of	ADP
admet-530	223	16	the	the	DET
admet-530	223	17	creative	creative	ADJ
admet-530	223	18	commons	common	NOUN
admet-530	223	19	attribution	attribution	NOUN
admet-530	223	20	license	license	NOUN
admet-530	223	21	(	(	PUNCT
admet-530	223	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-530	223	23	)	)	PUNCT
admet-530	223	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN