id	sid	tid	token	lemma	pos
admet-535	1	1	cellular	cellular	ADJ
admet-535	1	2	membrane	membrane	NOUN
admet-535	1	3	affinity	affinity	NOUN
admet-535	1	4	chromatography	chromatography	NOUN
admet-535	1	5	(	(	PUNCT
admet-535	1	6	cmac	cmac	PROPN
admet-535	1	7	)	)	PUNCT
admet-535	1	8	in	in	ADP
admet-535	1	9	drug	drug	NOUN
admet-535	1	10	discovery	discovery	NOUN
admet-535	1	11	from	from	ADP
admet-535	1	12	complex	complex	ADJ
admet-535	1	13	natural	natural	ADJ
admet-535	1	14	matrices	matrix	NOUN
admet-535	1	15	doi	doi	NOUN
admet-535	1	16	:	:	PUNCT
admet-535	1	17	10.5599	10.5599	NUM
admet-535	1	18	/	/	SYM
admet-535	1	19	admet.535	admet.535	PROPN
admet-535	1	20	200	200	NUM
admet-535	1	21	admet	admet	X
admet-535	1	22	&	&	CCONJ
admet-535	1	23	dmpk	dmpk	PROPN
admet-535	1	24	6(3	6(3	PROPN
admet-535	1	25	)	)	PUNCT
admet-535	1	26	(	(	PUNCT
admet-535	1	27	2018	2018	NUM
admet-535	1	28	)	)	PUNCT
admet-535	1	29	200	200	NUM
admet-535	1	30	-	-	SYM
admet-535	1	31	214	214	NUM
admet-535	1	32	;	;	PUNCT
admet-535	1	33	doi	doi	NOUN
admet-535	1	34	:	:	PUNCT
admet-535	1	35	http://dx.doi.org/10.5599/admet.535	http://dx.doi.org/10.5599/admet.535	PROPN
admet-535	1	36	open	open	ADJ
admet-535	1	37	access	access	NOUN
admet-535	1	38	:	:	PUNCT
admet-535	1	39	issn	issn	PROPN
admet-535	1	40	:	:	PUNCT
admet-535	1	41	1848	1848	NUM
admet-535	1	42	-	-	SYM
admet-535	1	43	7718	7718	NUM
admet-535	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-535	1	45	review	review	NOUN
admet-535	1	46	cellular	cellular	ADJ
admet-535	1	47	membrane	membrane	NOUN
admet-535	1	48	affinity	affinity	NOUN
admet-535	1	49	chromatography	chromatography	NOUN
admet-535	1	50	(	(	PUNCT
admet-535	1	51	cmac	cmac	PROPN
admet-535	1	52	)	)	PUNCT
admet-535	1	53	in	in	ADP
admet-535	1	54	drug	drug	NOUN
admet-535	1	55	discovery	discovery	NOUN
admet-535	1	56	from	from	ADP
admet-535	1	57	complex	complex	ADJ
admet-535	1	58	natural	natural	ADJ
admet-535	1	59	matrices	matrix	NOUN
admet-535	1	60	cayman	cayman	NOUN
admet-535	1	61	stephen1	stephen1	PROPN
admet-535	1	62	,	,	PUNCT
admet-535	1	63	abdelfatteh	abdelfatteh	PROPN
admet-535	1	64	el	el	PROPN
admet-535	1	65	omri2	omri2	PROPN
admet-535	1	66	,	,	PUNCT
admet-535	1	67	lukasz	lukasz	PROPN
admet-535	1	68	ciesla*1	ciesla*1	PROPN
admet-535	1	69	1	1	NUM
admet-535	1	70	department	department	NOUN
admet-535	1	71	of	of	ADP
admet-535	1	72	biological	biological	ADJ
admet-535	1	73	sciences	science	NOUN
admet-535	1	74	,	,	PUNCT
admet-535	1	75	the	the	DET
admet-535	1	76	university	university	NOUN
admet-535	1	77	of	of	ADP
admet-535	1	78	alabama	alabama	PROPN
admet-535	1	79	,	,	PUNCT
admet-535	1	80	science	science	NOUN
admet-535	1	81	and	and	CCONJ
admet-535	1	82	engineering	engineering	NOUN
admet-535	1	83	complex	complex	ADJ
admet-535	1	84	2329	2329	NUM
admet-535	1	85	tuscaloosa	tuscaloosa	NOUN
admet-535	1	86	,	,	PUNCT
admet-535	1	87	al	al	PROPN
admet-535	1	88	35487	35487	NUM
admet-535	1	89	,	,	PUNCT
admet-535	1	90	usa	usa	PROPN
admet-535	1	91	2	2	NUM
admet-535	1	92	genomics	genomic	NOUN
admet-535	1	93	and	and	CCONJ
admet-535	1	94	biotechnology	biotechnology	NOUN
admet-535	1	95	section	section	NOUN
admet-535	1	96	and	and	CCONJ
admet-535	1	97	research	research	NOUN
admet-535	1	98	group	group	NOUN
admet-535	1	99	,	,	PUNCT
admet-535	1	100	department	department	NOUN
admet-535	1	101	of	of	ADP
admet-535	1	102	biological	biological	ADJ
admet-535	1	103	sciences	science	NOUN
admet-535	1	104	,	,	PUNCT
admet-535	1	105	faculty	faculty	NOUN
admet-535	1	106	of	of	ADP
admet-535	1	107	science	science	NOUN
admet-535	1	108	,	,	PUNCT
admet-535	1	109	king	king	PROPN
admet-535	1	110	abdulaziz	abdulaziz	PROPN
admet-535	1	111	university	university	PROPN
admet-535	1	112	(	(	PUNCT
admet-535	1	113	kau	kau	PROPN
admet-535	1	114	)	)	PUNCT
admet-535	1	115	,	,	PUNCT
admet-535	1	116	jeddah	jeddah	PROPN
admet-535	1	117	21589	21589	NUM
admet-535	1	118	,	,	PUNCT
admet-535	1	119	box	box	NOUN
admet-535	1	120	80141	80141	NUM
admet-535	1	121	,	,	PUNCT
admet-535	1	122	saudi	saudi	PROPN
admet-535	1	123	arabia	arabia	PROPN
admet-535	1	124	*	*	PUNCT
admet-535	1	125	corresponding	correspond	VERB
admet-535	1	126	author	author	NOUN
admet-535	1	127	:	:	PUNCT
admet-535	1	128	e	e	NOUN
admet-535	1	129	-	-	NOUN
admet-535	1	130	mail	mail	NOUN
admet-535	1	131	:	:	PUNCT
admet-535	1	132	lmciesla@ua.edu	lmciesla@ua.edu	PROPN
admet-535	1	133	;	;	PUNCT
admet-535	1	134	tel	tel	PROPN
admet-535	1	135	.	.	PUNCT
admet-535	1	136	:	:	PUNCT
admet-535	2	1	+1	+1	ADJ
admet-535	2	2	-	-	PUNCT
admet-535	2	3	205	205	NUM
admet-535	2	4	-	-	PUNCT
admet-535	2	5	348	348	NUM
admet-535	2	6	-	-	PUNCT
admet-535	2	7	1828	1828	NUM
admet-535	2	8	;	;	PUNCT
admet-535	2	9	received	receive	VERB
admet-535	2	10	:	:	PUNCT
admet-535	2	11	april	april	PROPN
admet-535	2	12	08	08	NUM
admet-535	2	13	,	,	PUNCT
admet-535	2	14	2018	2018	NUM
admet-535	2	15	;	;	PUNCT
admet-535	2	16	revised	revise	VERB
admet-535	2	17	:	:	PUNCT
admet-535	2	18	may	may	AUX
admet-535	2	19	06	06	NUM
admet-535	2	20	,	,	PUNCT
admet-535	2	21	2018	2018	NUM
admet-535	2	22	;	;	PUNCT
admet-535	2	23	published	publish	VERB
admet-535	2	24	:	:	PUNCT
admet-535	2	25	may	may	AUX
admet-535	2	26	21	21	NUM
admet-535	2	27	,	,	PUNCT
admet-535	2	28	2018	2018	NUM
admet-535	2	29	abstract	abstract	ADJ
admet-535	2	30	secondary	secondary	ADJ
admet-535	2	31	plant	plant	NOUN
admet-535	2	32	metabolites	metabolite	NOUN
admet-535	2	33	are	be	AUX
admet-535	2	34	evolutionary	evolutionary	ADJ
admet-535	2	35	-	-	PUNCT
admet-535	2	36	designed	design	VERB
admet-535	2	37	molecules	molecule	NOUN
admet-535	2	38	that	that	PRON
admet-535	2	39	interact	interact	VERB
admet-535	2	40	with	with	ADP
admet-535	2	41	multiple	multiple	ADJ
admet-535	2	42	biological	biological	ADJ
admet-535	2	43	targets	target	NOUN
admet-535	2	44	in	in	ADP
admet-535	2	45	human	human	ADJ
admet-535	2	46	organisms	organism	NOUN
admet-535	2	47	.	.	PUNCT
admet-535	3	1	identification	identification	NOUN
admet-535	3	2	of	of	ADP
admet-535	3	3	pharmacologically	pharmacologically	ADV
admet-535	3	4	active	active	ADJ
admet-535	3	5	phytochemicals	phytochemical	NOUN
admet-535	3	6	is	be	AUX
admet-535	3	7	usually	usually	ADV
admet-535	3	8	a	a	DET
admet-535	3	9	time	time	NOUN
admet-535	3	10	consuming	consume	VERB
admet-535	3	11	and	and	CCONJ
admet-535	3	12	costly	costly	ADJ
admet-535	3	13	process	process	NOUN
admet-535	3	14	.	.	PUNCT
admet-535	4	1	cellular	cellular	ADJ
admet-535	4	2	membrane	membrane	NOUN
admet-535	4	3	affinity	affinity	NOUN
admet-535	4	4	chromatography	chromatography	NOUN
admet-535	4	5	(	(	PUNCT
admet-535	4	6	cmac	cmac	PROPN
admet-535	4	7	)	)	PUNCT
admet-535	4	8	allows	allow	VERB
admet-535	4	9	the	the	DET
admet-535	4	10	detection	detection	NOUN
admet-535	4	11	of	of	ADP
admet-535	4	12	secondary	secondary	ADJ
admet-535	4	13	metabolites	metabolite	NOUN
admet-535	4	14	present	present	ADJ
admet-535	4	15	in	in	ADP
admet-535	4	16	complex	complex	ADJ
admet-535	4	17	natural	natural	ADJ
admet-535	4	18	matrices	matrix	NOUN
admet-535	4	19	,	,	PUNCT
admet-535	4	20	e.g.	e.g.	ADV
admet-535	4	21	plant	plant	NOUN
admet-535	4	22	extracts	extract	NOUN
admet-535	4	23	and	and	CCONJ
admet-535	4	24	their	their	PRON
admet-535	4	25	interactions	interaction	NOUN
admet-535	4	26	with	with	ADP
admet-535	4	27	the	the	DET
admet-535	4	28	immobilized	immobilized	ADJ
admet-535	4	29	fully	fully	ADV
admet-535	4	30	-	-	PUNCT
admet-535	4	31	functional	functional	ADJ
admet-535	4	32	transmembrane	transmembrane	ADJ
admet-535	4	33	proteins	protein	NOUN
admet-535	4	34	.	.	PUNCT
admet-535	5	1	after	after	ADP
admet-535	5	2	the	the	DET
admet-535	5	3	isolation	isolation	NOUN
admet-535	5	4	process	process	NOUN
admet-535	5	5	of	of	ADP
admet-535	5	6	the	the	DET
admet-535	5	7	binding	bind	VERB
admet-535	5	8	compounds	compound	NOUN
admet-535	5	9	,	,	PUNCT
admet-535	5	10	cmac	cmac	NOUN
admet-535	5	11	columns	column	NOUN
admet-535	5	12	can	can	AUX
admet-535	5	13	be	be	AUX
admet-535	5	14	used	use	VERB
admet-535	5	15	to	to	PART
admet-535	5	16	study	study	VERB
admet-535	5	17	the	the	DET
admet-535	5	18	binding	bind	VERB
admet-535	5	19	process	process	NOUN
admet-535	5	20	between	between	ADP
admet-535	5	21	the	the	DET
admet-535	5	22	potential	potential	ADJ
admet-535	5	23	new	new	ADJ
admet-535	5	24	ligands	ligand	NOUN
admet-535	5	25	and	and	CCONJ
admet-535	5	26	the	the	DET
admet-535	5	27	immobilized	immobilized	ADJ
admet-535	5	28	transmembrane	transmembrane	ADJ
admet-535	5	29	protein	protein	NOUN
admet-535	5	30	target	target	NOUN
admet-535	5	31	.	.	PUNCT
admet-535	6	1	the	the	DET
admet-535	6	2	following	follow	VERB
admet-535	6	3	parameters	parameter	NOUN
admet-535	6	4	can	can	AUX
admet-535	6	5	be	be	AUX
admet-535	6	6	determined	determine	VERB
admet-535	6	7	using	use	VERB
admet-535	6	8	cmac	cmac	NOUN
admet-535	6	9	columns	column	NOUN
admet-535	6	10	:	:	PUNCT
admet-535	6	11	binding	bind	VERB
admet-535	6	12	affinity	affinity	NOUN
admet-535	6	13	(	(	PUNCT
admet-535	6	14	kd	kd	PROPN
admet-535	6	15	)	)	PUNCT
admet-535	6	16	,	,	PUNCT
admet-535	6	17	association	association	NOUN
admet-535	6	18	rate	rate	NOUN
admet-535	6	19	constant	constant	ADJ
admet-535	6	20	(	(	PUNCT
admet-535	6	21	kon	kon	PROPN
admet-535	6	22	)	)	PUNCT
admet-535	6	23	,	,	PUNCT
admet-535	6	24	dissociation	dissociation	NOUN
admet-535	6	25	rate	rate	NOUN
admet-535	6	26	constant	constant	ADJ
admet-535	6	27	(	(	PUNCT
admet-535	6	28	koff	koff	PROPN
admet-535	6	29	)	)	PUNCT
admet-535	6	30	and	and	CCONJ
admet-535	6	31	the	the	DET
admet-535	6	32	equilibrium	equilibrium	NOUN
admet-535	6	33	constant	constant	ADJ
admet-535	6	34	for	for	ADP
admet-535	6	35	complex	complex	ADJ
admet-535	6	36	formation	formation	NOUN
admet-535	6	37	(	(	PUNCT
admet-535	6	38	k	k	NOUN
admet-535	6	39	)	)	PUNCT
admet-535	6	40	.	.	PUNCT
admet-535	7	1	this	this	DET
admet-535	7	2	review	review	NOUN
admet-535	7	3	summarizes	summarize	VERB
admet-535	7	4	the	the	DET
admet-535	7	5	preparation	preparation	NOUN
admet-535	7	6	steps	step	NOUN
admet-535	7	7	and	and	CCONJ
admet-535	7	8	the	the	DET
admet-535	7	9	use	use	NOUN
admet-535	7	10	of	of	ADP
admet-535	7	11	cmac	cmac	NOUN
admet-535	7	12	columns	column	NOUN
admet-535	7	13	in	in	ADP
admet-535	7	14	the	the	DET
admet-535	7	15	drug	drug	NOUN
admet-535	7	16	discovery	discovery	NOUN
admet-535	7	17	process	process	NOUN
admet-535	7	18	of	of	ADP
admet-535	7	19	new	new	ADJ
admet-535	7	20	potential	potential	ADJ
admet-535	7	21	drug	drug	NOUN
admet-535	7	22	leads	lead	VERB
admet-535	7	23	present	present	ADJ
admet-535	7	24	in	in	ADP
admet-535	7	25	complex	complex	ADJ
admet-535	7	26	natural	natural	ADJ
admet-535	7	27	matrices	matrix	NOUN
admet-535	7	28	.	.	PUNCT
admet-535	8	1	keywords	keyword	VERB
admet-535	8	2	artificial	artificial	ADJ
admet-535	8	3	membrane	membrane	NOUN
admet-535	8	4	stationary	stationary	ADJ
admet-535	8	5	phase	phase	NOUN
admet-535	8	6	;	;	PUNCT
admet-535	8	7	bioassay	bioassay	NOUN
admet-535	8	8	;	;	PUNCT
admet-535	8	9	chromatography	chromatography	NOUN
admet-535	8	10	;	;	PUNCT
admet-535	8	11	frontal	frontal	ADJ
admet-535	8	12	affinity	affinity	NOUN
admet-535	8	13	chromatography	chromatography	NOUN
admet-535	8	14	;	;	PUNCT
admet-535	8	15	iam.pc	iam.pc	PROPN
admet-535	8	16	;	;	PUNCT
admet-535	8	17	immobilized	immobilized	ADJ
admet-535	8	18	protein	protein	NOUN
admet-535	8	19	;	;	PUNCT
admet-535	8	20	phytochemicals	phytochemical	NOUN
admet-535	8	21	;	;	PUNCT
admet-535	8	22	plant	plant	NOUN
admet-535	8	23	extracts	extract	NOUN
admet-535	8	24	introduction	introduction	NOUN
admet-535	8	25	for	for	ADP
admet-535	8	26	thousands	thousand	NOUN
admet-535	8	27	of	of	ADP
admet-535	8	28	years	year	NOUN
admet-535	8	29	,	,	PUNCT
admet-535	8	30	humankind	humankind	NOUN
admet-535	8	31	has	have	AUX
admet-535	8	32	relied	rely	VERB
admet-535	8	33	on	on	ADP
admet-535	8	34	remedies	remedy	NOUN
admet-535	8	35	obtained	obtain	VERB
admet-535	8	36	from	from	ADP
admet-535	8	37	nature	nature	NOUN
admet-535	8	38	,	,	PUNCT
admet-535	8	39	mostly	mostly	ADV
admet-535	8	40	from	from	ADP
admet-535	8	41	plants	plant	NOUN
admet-535	8	42	.	.	PUNCT
admet-535	9	1	secondary	secondary	ADJ
admet-535	9	2	plant	plant	NOUN
admet-535	9	3	metabolites	metabolite	NOUN
admet-535	9	4	can	can	AUX
admet-535	9	5	be	be	AUX
admet-535	9	6	considered	consider	VERB
admet-535	9	7	as	as	ADP
admet-535	9	8	evolutionary	evolutionary	ADJ
admet-535	9	9	designed	design	VERB
admet-535	9	10	drugs	drug	NOUN
admet-535	9	11	,	,	PUNCT
admet-535	9	12	that	that	PRON
admet-535	9	13	have	have	AUX
admet-535	9	14	evolved	evolve	VERB
admet-535	9	15	as	as	ADP
admet-535	9	16	a	a	DET
admet-535	9	17	means	means	NOUN
admet-535	9	18	of	of	ADP
admet-535	9	19	herbal	herbal	ADJ
admet-535	9	20	communication	communication	NOUN
admet-535	9	21	with	with	ADP
admet-535	9	22	other	other	ADJ
admet-535	9	23	organisms	organism	NOUN
admet-535	9	24	.	.	PUNCT
admet-535	10	1	plants	plant	NOUN
admet-535	10	2	use	use	VERB
admet-535	10	3	the	the	DET
admet-535	10	4	array	array	NOUN
admet-535	10	5	of	of	ADP
admet-535	10	6	phytochemicals	phytochemical	NOUN
admet-535	10	7	that	that	PRON
admet-535	10	8	serve	serve	VERB
admet-535	10	9	multiple	multiple	ADJ
admet-535	10	10	purposes	purpose	NOUN
admet-535	10	11	,	,	PUNCT
admet-535	10	12	for	for	ADP
admet-535	10	13	example	example	NOUN
admet-535	10	14	:	:	PUNCT
admet-535	10	15	protection	protection	NOUN
admet-535	10	16	from	from	ADP
admet-535	10	17	abiotic	abiotic	ADJ
admet-535	10	18	stress	stress	NOUN
admet-535	10	19	,	,	PUNCT
admet-535	10	20	like	like	ADP
admet-535	10	21	excessive	excessive	ADJ
admet-535	10	22	uv	uv	NOUN
admet-535	10	23	radiation	radiation	NOUN
admet-535	10	24	(	(	PUNCT
admet-535	10	25	polyphenols	polyphenol	NOUN
admet-535	10	26	,	,	PUNCT
admet-535	10	27	terpenes	terpene	NOUN
admet-535	10	28	and	and	CCONJ
admet-535	10	29	terpenoids	terpenoid	NOUN
admet-535	10	30	)	)	PUNCT
admet-535	10	31	,	,	PUNCT
admet-535	10	32	attraction	attraction	NOUN
admet-535	10	33	of	of	ADP
admet-535	10	34	pollinators	pollinator	NOUN
admet-535	10	35	(	(	PUNCT
admet-535	10	36	volatile	volatile	ADJ
admet-535	10	37	terpenes	terpene	NOUN
admet-535	10	38	)	)	PUNCT
admet-535	10	39	,	,	PUNCT
admet-535	10	40	warding	ward	VERB
admet-535	10	41	off	off	ADP
admet-535	10	42	herbivores	herbivore	NOUN
admet-535	10	43	(	(	PUNCT
admet-535	10	44	noxious	noxious	ADJ
admet-535	10	45	phytochemicals	phytochemical	NOUN
admet-535	10	46	,	,	PUNCT
admet-535	10	47	e.g.	e.g.	ADV
admet-535	10	48	alkaloids	alkaloid	NOUN
admet-535	10	49	)	)	PUNCT
admet-535	10	50	,	,	PUNCT
admet-535	10	51	protection	protection	NOUN
admet-535	10	52	from	from	ADP
admet-535	10	53	bacterial	bacterial	ADJ
admet-535	10	54	or	or	CCONJ
admet-535	10	55	fungal	fungal	ADJ
admet-535	10	56	infections	infection	NOUN
admet-535	10	57	(	(	PUNCT
admet-535	10	58	polyphenols	polyphenol	NOUN
admet-535	10	59	,	,	PUNCT
admet-535	10	60	terpenoids	terpenoid	NOUN
admet-535	10	61	,	,	PUNCT
admet-535	10	62	etc	etc	X
admet-535	10	63	)	)	PUNCT
admet-535	11	1	[	[	X
admet-535	11	2	1	1	NUM
admet-535	11	3	-	-	SYM
admet-535	11	4	4	4	NUM
admet-535	11	5	]	]	PUNCT
admet-535	11	6	.	.	PUNCT
admet-535	12	1	herbivores	herbivore	NOUN
admet-535	12	2	evolved	evolve	VERB
admet-535	12	3	different	different	ADJ
admet-535	12	4	forms	form	NOUN
admet-535	12	5	of	of	ADP
admet-535	12	6	biochemical	biochemical	ADJ
admet-535	12	7	changes	change	NOUN
admet-535	12	8	,	,	PUNCT
admet-535	12	9	that	that	PRON
admet-535	12	10	protect	protect	VERB
admet-535	12	11	them	they	PRON
admet-535	12	12	from	from	ADP
admet-535	12	13	the	the	DET
admet-535	12	14	deleterious	deleterious	ADJ
admet-535	12	15	effects	effect	NOUN
admet-535	12	16	of	of	ADP
admet-535	12	17	some	some	PRON
admet-535	12	18	of	of	ADP
admet-535	12	19	the	the	DET
admet-535	12	20	phytochemicals	phytochemical	NOUN
admet-535	12	21	,	,	PUNCT
admet-535	12	22	for	for	ADP
admet-535	12	23	example	example	NOUN
admet-535	12	24	:	:	PUNCT
admet-535	12	25	cyp450	cyp450	NOUN
admet-535	12	26	superfamily	superfamily	ADV
admet-535	12	27	of	of	ADP
admet-535	12	28	enzymes	enzyme	NOUN
admet-535	12	29	,	,	PUNCT
admet-535	12	30	transporter	transporter	NOUN
admet-535	12	31	proteins	protein	NOUN
admet-535	12	32	and	and	CCONJ
admet-535	12	33	stress	stress	NOUN
admet-535	12	34	-	-	PUNCT
admet-535	12	35	response	response	NOUN
admet-535	12	36	cellular	cellular	ADJ
admet-535	12	37	signalling	signal	VERB
admet-535	12	38	pathways	pathway	NOUN
admet-535	13	1	[	[	X
admet-535	13	2	1	1	NUM
admet-535	13	3	-	-	SYM
admet-535	13	4	4	4	NUM
admet-535	13	5	]	]	PUNCT
admet-535	13	6	.	.	PUNCT
admet-535	14	1	many	many	ADJ
admet-535	14	2	of	of	ADP
admet-535	14	3	these	these	DET
admet-535	14	4	mechanisms	mechanism	NOUN
admet-535	14	5	are	be	AUX
admet-535	14	6	highly	highly	ADV
admet-535	14	7	conserved	conserve	VERB
admet-535	14	8	adaptive	adaptive	ADJ
admet-535	14	9	stress	stress	NOUN
admet-535	14	10	response	response	NOUN
admet-535	14	11	systems	system	NOUN
admet-535	14	12	that	that	PRON
admet-535	14	13	humans	human	NOUN
admet-535	14	14	share	share	VERB
admet-535	14	15	with	with	ADP
admet-535	14	16	simple	simple	ADJ
admet-535	14	17	herbivores	herbivore	NOUN
admet-535	14	18	.	.	PUNCT
admet-535	15	1	numerous	numerous	ADJ
admet-535	15	2	secondary	secondary	ADJ
admet-535	15	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-535	15	4	tel:205	tel:205	NOUN
admet-535	15	5	-	-	PUNCT
admet-535	15	6	348	348	NUM
admet-535	15	7	-	-	PUNCT
admet-535	15	8	1828	1828	NUM
admet-535	15	9	admet	admet	NOUN
admet-535	15	10	&	&	CCONJ
admet-535	15	11	dmpk	dmpk	PROPN
admet-535	15	12	6(3	6(3	PROPN
admet-535	15	13	)	)	PUNCT
admet-535	15	14	(	(	PUNCT
admet-535	15	15	2018	2018	NUM
admet-535	15	16	)	)	PUNCT
admet-535	15	17	200	200	NUM
admet-535	15	18	-	-	SYM
admet-535	15	19	214	214	NUM
admet-535	15	20	cell	cell	NOUN
admet-535	15	21	membrane	membrane	NOUN
admet-535	15	22	affinity	affinity	NOUN
admet-535	15	23	chromatography	chromatography	NOUN
admet-535	15	24	in	in	ADP
admet-535	15	25	drug	drug	NOUN
admet-535	15	26	discovery	discovery	NOUN
admet-535	15	27	doi	doi	PROPN
admet-535	15	28	:	:	PUNCT
admet-535	15	29	10.5599	10.5599	NUM
admet-535	15	30	/	/	SYM
admet-535	15	31	admet.535	admet.535	NOUN
admet-535	15	32	201	201	NUM
admet-535	15	33	metabolites	metabolite	NOUN
admet-535	15	34	can	can	AUX
admet-535	15	35	be	be	AUX
admet-535	15	36	considered	consider	VERB
admet-535	15	37	as	as	SCONJ
admet-535	15	38	already	already	ADV
admet-535	15	39	optimized	optimize	VERB
admet-535	15	40	drug	drug	NOUN
admet-535	15	41	leads	lead	VERB
admet-535	15	42	targeting	target	VERB
admet-535	15	43	specific	specific	ADJ
admet-535	15	44	receptors	receptor	NOUN
admet-535	15	45	,	,	PUNCT
admet-535	15	46	enzymes	enzyme	NOUN
admet-535	15	47	or	or	CCONJ
admet-535	15	48	biochemical	biochemical	ADJ
admet-535	15	49	processes	process	NOUN
admet-535	15	50	[	[	X
admet-535	15	51	5	5	NUM
admet-535	15	52	]	]	PUNCT
admet-535	15	53	.	.	PUNCT
admet-535	16	1	the	the	DET
admet-535	16	2	huge	huge	ADJ
admet-535	16	3	potential	potential	NOUN
admet-535	16	4	of	of	ADP
admet-535	16	5	plant	plant	NOUN
admet-535	16	6	-	-	PUNCT
admet-535	16	7	derived	derive	VERB
admet-535	16	8	drugs	drug	NOUN
admet-535	16	9	is	be	AUX
admet-535	16	10	exemplified	exemplify	VERB
admet-535	16	11	by	by	ADP
admet-535	16	12	numerous	numerous	ADJ
admet-535	16	13	secondary	secondary	ADJ
admet-535	16	14	plant	plant	NOUN
admet-535	16	15	metabolites	metabolite	NOUN
admet-535	16	16	currently	currently	ADV
admet-535	16	17	used	use	VERB
admet-535	16	18	in	in	ADP
admet-535	16	19	clinics	clinic	NOUN
admet-535	16	20	,	,	PUNCT
admet-535	16	21	for	for	ADP
admet-535	16	22	example	example	NOUN
admet-535	16	23	,	,	PUNCT
admet-535	16	24	artemisinin	artemisinin	PROPN
admet-535	16	25	,	,	PUNCT
admet-535	16	26	ivermectin	ivermectin	NOUN
admet-535	16	27	,	,	PUNCT
admet-535	16	28	morphine	morphine	NOUN
admet-535	16	29	,	,	PUNCT
admet-535	16	30	digitoxin	digitoxin	PROPN
admet-535	16	31	,	,	PUNCT
admet-535	16	32	vincristine	vincristine	NOUN
admet-535	16	33	,	,	PUNCT
admet-535	16	34	podophyllotoxin	podophyllotoxin	NOUN
admet-535	16	35	,	,	PUNCT
admet-535	16	36	and	and	CCONJ
admet-535	16	37	many	many	ADJ
admet-535	16	38	others	other	NOUN
admet-535	17	1	[	[	X
admet-535	17	2	6	6	NUM
admet-535	17	3	]	]	PUNCT
admet-535	17	4	.	.	PUNCT
admet-535	18	1	unfortunately	unfortunately	ADV
admet-535	18	2	,	,	PUNCT
admet-535	18	3	plants	plant	NOUN
admet-535	18	4	do	do	AUX
admet-535	18	5	not	not	PART
admet-535	18	6	reveal	reveal	VERB
admet-535	18	7	their	their	PRON
admet-535	18	8	secrets	secret	NOUN
admet-535	18	9	easily	easily	ADV
admet-535	18	10	as	as	SCONJ
admet-535	18	11	the	the	DET
admet-535	18	12	identification	identification	NOUN
admet-535	18	13	of	of	ADP
admet-535	18	14	pharmacologically	pharmacologically	ADV
admet-535	18	15	active	active	ADJ
admet-535	18	16	phytochemicals	phytochemical	NOUN
admet-535	18	17	is	be	AUX
admet-535	18	18	usually	usually	ADV
admet-535	18	19	a	a	DET
admet-535	18	20	difficult	difficult	ADJ
admet-535	18	21	and	and	CCONJ
admet-535	18	22	time	time	NOUN
admet-535	18	23	-	-	PUNCT
admet-535	18	24	consuming	consume	VERB
admet-535	18	25	process	process	NOUN
admet-535	18	26	[	[	X
admet-535	18	27	7	7	NUM
admet-535	18	28	]	]	PUNCT
admet-535	18	29	.	.	PUNCT
admet-535	19	1	many	many	ADJ
admet-535	19	2	pharmaceutical	pharmaceutical	ADJ
admet-535	19	3	companies	company	NOUN
admet-535	19	4	have	have	AUX
admet-535	19	5	abandoned	abandon	VERB
admet-535	19	6	drug	drug	NOUN
admet-535	19	7	discovery	discovery	NOUN
admet-535	19	8	from	from	ADP
admet-535	19	9	natural	natural	ADJ
admet-535	19	10	products	product	NOUN
admet-535	19	11	,	,	PUNCT
admet-535	19	12	considering	consider	VERB
admet-535	19	13	it	it	PRON
admet-535	19	14	as	as	ADP
admet-535	19	15	a	a	DET
admet-535	19	16	demanding	demand	VERB
admet-535	19	17	high	high	ADJ
admet-535	19	18	resource	resource	NOUN
admet-535	19	19	commitment	commitment	NOUN
admet-535	19	20	and	and	CCONJ
admet-535	19	21	often	often	ADV
admet-535	19	22	leading	lead	VERB
admet-535	19	23	to	to	ADP
admet-535	19	24	disappointing	disappointing	ADJ
admet-535	19	25	results	result	NOUN
admet-535	19	26	(	(	PUNCT
admet-535	19	27	identification	identification	NOUN
admet-535	19	28	of	of	ADP
admet-535	19	29	known	know	VERB
admet-535	19	30	compounds	compound	NOUN
admet-535	19	31	and	and	CCONJ
admet-535	19	32	poor	poor	ADJ
admet-535	19	33	biological	biological	ADJ
admet-535	19	34	activity	activity	NOUN
admet-535	19	35	)	)	PUNCT
admet-535	19	36	.	.	PUNCT
admet-535	20	1	technical	technical	ADJ
admet-535	20	2	problems	problem	NOUN
admet-535	20	3	also	also	ADV
admet-535	20	4	prevent	prevent	VERB
admet-535	20	5	now	now	ADV
admet-535	20	6	-	-	PUNCT
admet-535	20	7	commonly	commonly	ADV
admet-535	20	8	used	use	VERB
admet-535	20	9	high	high	ADJ
admet-535	20	10	-	-	PUNCT
admet-535	20	11	throughput	throughput	NOUN
admet-535	20	12	screening	screening	NOUN
admet-535	20	13	(	(	PUNCT
admet-535	20	14	hts	ht	NOUN
admet-535	20	15	)	)	PUNCT
admet-535	20	16	techniques	technique	NOUN
admet-535	20	17	from	from	ADP
admet-535	20	18	testing	test	VERB
admet-535	20	19	complex	complex	ADJ
admet-535	20	20	natural	natural	ADJ
admet-535	20	21	matrices	matrix	NOUN
admet-535	20	22	for	for	ADP
admet-535	20	23	pharmacologically	pharmacologically	ADV
admet-535	20	24	active	active	ADJ
admet-535	20	25	compounds	compound	NOUN
admet-535	20	26	[	[	X
admet-535	20	27	8	8	NUM
admet-535	20	28	]	]	PUNCT
admet-535	20	29	.	.	PUNCT
admet-535	21	1	hts	hts	PROPN
admet-535	21	2	techniques	technique	NOUN
admet-535	21	3	are	be	AUX
admet-535	21	4	designed	design	VERB
admet-535	21	5	to	to	PART
admet-535	21	6	test	test	VERB
admet-535	21	7	huge	huge	ADJ
admet-535	21	8	libraries	library	NOUN
admet-535	21	9	of	of	ADP
admet-535	21	10	individual	individual	ADJ
admet-535	21	11	compounds	compound	NOUN
admet-535	21	12	.	.	PUNCT
admet-535	22	1	in	in	ADP
admet-535	22	2	cases	case	NOUN
admet-535	22	3	of	of	ADP
admet-535	22	4	complex	complex	ADJ
admet-535	22	5	samples	sample	NOUN
admet-535	22	6	,	,	PUNCT
admet-535	22	7	only	only	ADV
admet-535	22	8	a	a	DET
admet-535	22	9	simple	simple	ADJ
admet-535	22	10	answer	answer	NOUN
admet-535	22	11	would	would	AUX
admet-535	22	12	be	be	AUX
admet-535	22	13	delivered	deliver	VERB
admet-535	22	14	if	if	SCONJ
admet-535	22	15	the	the	DET
admet-535	22	16	hts	hts	PROPN
admet-535	22	17	approach	approach	NOUN
admet-535	22	18	was	be	AUX
admet-535	22	19	used	use	VERB
admet-535	22	20	:	:	PUNCT
admet-535	22	21	the	the	DET
admet-535	22	22	extract	extract	NOUN
admet-535	22	23	is	be	AUX
admet-535	22	24	active	active	ADJ
admet-535	22	25	or	or	CCONJ
admet-535	22	26	not	not	PART
admet-535	22	27	active	active	ADJ
admet-535	22	28	.	.	PUNCT
admet-535	23	1	identification	identification	NOUN
admet-535	23	2	of	of	ADP
admet-535	23	3	pharmacologically	pharmacologically	ADV
admet-535	23	4	active	active	ADJ
admet-535	23	5	metabolites	metabolite	NOUN
admet-535	23	6	would	would	AUX
admet-535	23	7	have	have	VERB
admet-535	23	8	to	to	PART
admet-535	23	9	follow	follow	VERB
admet-535	23	10	the	the	DET
admet-535	23	11	hts	hts	PROPN
admet-535	23	12	approach	approach	NOUN
admet-535	23	13	.	.	PUNCT
admet-535	24	1	in	in	ADP
admet-535	24	2	the	the	DET
admet-535	24	3	traditional	traditional	ADJ
admet-535	24	4	approach	approach	NOUN
admet-535	24	5	to	to	ADP
admet-535	24	6	drug	drug	NOUN
admet-535	24	7	discovery	discovery	NOUN
admet-535	24	8	from	from	ADP
admet-535	24	9	natural	natural	ADJ
admet-535	24	10	samples	sample	NOUN
admet-535	24	11	,	,	PUNCT
admet-535	24	12	the	the	DET
admet-535	24	13	first	first	ADJ
admet-535	24	14	step	step	NOUN
admet-535	24	15	usually	usually	ADV
admet-535	24	16	involves	involve	VERB
admet-535	24	17	the	the	DET
admet-535	24	18	isolation	isolation	NOUN
admet-535	24	19	of	of	ADP
admet-535	24	20	individual	individual	ADJ
admet-535	24	21	compounds	compound	NOUN
admet-535	24	22	.	.	PUNCT
admet-535	25	1	this	this	DET
admet-535	25	2	step	step	NOUN
admet-535	25	3	often	often	ADV
admet-535	25	4	leads	lead	VERB
admet-535	25	5	to	to	ADP
admet-535	25	6	obtaining	obtain	VERB
admet-535	25	7	compounds	compound	NOUN
admet-535	25	8	which	which	PRON
admet-535	25	9	are	be	AUX
admet-535	25	10	easily	easily	ADV
admet-535	25	11	isolated	isolate	VERB
admet-535	25	12	with	with	ADP
admet-535	25	13	reasonable	reasonable	ADJ
admet-535	25	14	quantities	quantity	NOUN
admet-535	25	15	needed	need	VERB
admet-535	25	16	to	to	PART
admet-535	25	17	run	run	VERB
admet-535	25	18	biological	biological	ADJ
admet-535	25	19	activity	activity	NOUN
admet-535	25	20	assays	assay	NOUN
admet-535	25	21	.	.	PUNCT
admet-535	26	1	the	the	DET
admet-535	26	2	most	most	ADV
admet-535	26	3	abundant	abundant	ADJ
admet-535	26	4	secondary	secondary	ADJ
admet-535	26	5	metabolites	metabolite	NOUN
admet-535	26	6	are	be	AUX
admet-535	26	7	usually	usually	ADV
admet-535	26	8	isolated	isolate	VERB
admet-535	26	9	and	and	CCONJ
admet-535	26	10	many	many	ADJ
admet-535	26	11	of	of	ADP
admet-535	26	12	them	they	PRON
admet-535	26	13	have	have	VERB
admet-535	26	14	already	already	ADV
admet-535	26	15	well	well	ADV
admet-535	26	16	-	-	PUNCT
admet-535	26	17	established	establish	VERB
admet-535	26	18	and	and	CCONJ
admet-535	26	19	known	know	VERB
admet-535	26	20	pharmacological	pharmacological	ADJ
admet-535	26	21	activity	activity	NOUN
admet-535	26	22	profiles	profile	NOUN
admet-535	26	23	[	[	X
admet-535	26	24	7	7	NUM
admet-535	26	25	]	]	PUNCT
admet-535	26	26	.	.	PUNCT
admet-535	27	1	the	the	DET
admet-535	27	2	use	use	NOUN
admet-535	27	3	of	of	ADP
admet-535	27	4	bio	bio	NOUN
admet-535	27	5	-	-	PUNCT
admet-535	27	6	guided	guide	VERB
admet-535	27	7	fractionation	fractionation	NOUN
admet-535	27	8	has	have	AUX
admet-535	27	9	provided	provide	VERB
admet-535	27	10	some	some	DET
admet-535	27	11	solutions	solution	NOUN
admet-535	27	12	by	by	ADP
admet-535	27	13	narrowing	narrow	VERB
admet-535	27	14	down	down	ADP
admet-535	27	15	the	the	DET
admet-535	27	16	isolation	isolation	NOUN
admet-535	27	17	process	process	NOUN
admet-535	27	18	to	to	ADP
admet-535	27	19	subfractions	subfraction	NOUN
admet-535	27	20	that	that	PRON
admet-535	27	21	have	have	AUX
admet-535	27	22	been	be	AUX
admet-535	27	23	identified	identify	VERB
admet-535	27	24	as	as	ADP
admet-535	27	25	having	have	VERB
admet-535	27	26	the	the	DET
admet-535	27	27	highest	high	ADJ
admet-535	27	28	activity	activity	NOUN
admet-535	27	29	.	.	PUNCT
admet-535	28	1	however	however	ADV
admet-535	28	2	,	,	PUNCT
admet-535	28	3	bio	bio	ADJ
admet-535	28	4	-	-	PUNCT
admet-535	28	5	guided	guide	VERB
admet-535	28	6	fractionation	fractionation	NOUN
admet-535	28	7	still	still	ADV
admet-535	28	8	requires	require	VERB
admet-535	28	9	repetitive	repetitive	ADJ
admet-535	28	10	multiple	multiple	ADJ
admet-535	28	11	steps	step	NOUN
admet-535	28	12	to	to	PART
admet-535	28	13	identify	identify	VERB
admet-535	28	14	the	the	DET
admet-535	28	15	subfractions	subfraction	NOUN
admet-535	28	16	that	that	PRON
admet-535	28	17	are	be	AUX
admet-535	28	18	rich	rich	ADJ
admet-535	28	19	in	in	ADP
admet-535	28	20	biologically	biologically	ADV
admet-535	28	21	active	active	ADJ
admet-535	28	22	compounds	compound	NOUN
admet-535	28	23	.	.	PUNCT
admet-535	29	1	different	different	ADJ
admet-535	29	2	attempts	attempt	NOUN
admet-535	29	3	have	have	AUX
admet-535	29	4	been	be	AUX
admet-535	29	5	made	make	VERB
admet-535	29	6	to	to	PART
admet-535	29	7	shorten	shorten	VERB
admet-535	29	8	the	the	DET
admet-535	29	9	process	process	NOUN
admet-535	29	10	of	of	ADP
admet-535	29	11	drug	drug	NOUN
admet-535	29	12	lead	lead	NOUN
admet-535	29	13	identification	identification	NOUN
admet-535	29	14	from	from	ADP
admet-535	29	15	plant	plant	NOUN
admet-535	29	16	extracts	extract	NOUN
admet-535	29	17	.	.	PUNCT
admet-535	30	1	many	many	ADJ
admet-535	30	2	of	of	ADP
admet-535	30	3	these	these	DET
admet-535	30	4	attempts	attempt	NOUN
admet-535	30	5	focused	focus	VERB
admet-535	30	6	on	on	ADP
admet-535	30	7	developing	develop	VERB
admet-535	30	8	target	target	NOUN
admet-535	30	9	-	-	PUNCT
admet-535	30	10	oriented	orient	VERB
admet-535	30	11	assays	assay	NOUN
admet-535	30	12	enabling	enable	VERB
admet-535	30	13	identification	identification	NOUN
admet-535	30	14	of	of	ADP
admet-535	30	15	compounds	compound	NOUN
admet-535	30	16	with	with	ADP
admet-535	30	17	desired	desire	VERB
admet-535	30	18	activity	activity	NOUN
admet-535	30	19	.	.	PUNCT
admet-535	31	1	secondary	secondary	ADJ
admet-535	31	2	metabolites	metabolite	NOUN
admet-535	31	3	act	act	VERB
admet-535	31	4	by	by	ADP
admet-535	31	5	interacting	interact	VERB
admet-535	31	6	with	with	ADP
admet-535	31	7	numerous	numerous	ADJ
admet-535	31	8	targets	target	NOUN
admet-535	31	9	in	in	ADP
admet-535	31	10	the	the	DET
admet-535	31	11	human	human	ADJ
admet-535	31	12	body	body	NOUN
admet-535	31	13	,	,	PUNCT
admet-535	31	14	for	for	ADP
admet-535	31	15	example	example	NOUN
admet-535	31	16	,	,	PUNCT
admet-535	31	17	cytosolic	cytosolic	ADJ
admet-535	31	18	proteins	protein	NOUN
admet-535	31	19	or	or	CCONJ
admet-535	31	20	transmembrane	transmembrane	NOUN
admet-535	31	21	receptors	receptor	NOUN
admet-535	31	22	[	[	X
admet-535	31	23	5	5	NUM
admet-535	31	24	]	]	PUNCT
admet-535	31	25	.	.	PUNCT
admet-535	32	1	these	these	DET
admet-535	32	2	new	new	ADJ
admet-535	32	3	assays	assay	NOUN
admet-535	32	4	are	be	AUX
admet-535	32	5	designed	design	VERB
admet-535	32	6	to	to	PART
admet-535	32	7	screen	screen	VERB
admet-535	32	8	complex	complex	ADJ
admet-535	32	9	matrices	matrix	NOUN
admet-535	32	10	and	and	CCONJ
admet-535	32	11	identify	identify	VERB
admet-535	32	12	compounds	compound	NOUN
admet-535	32	13	that	that	PRON
admet-535	32	14	selectively	selectively	ADV
admet-535	32	15	interact	interact	VERB
admet-535	32	16	with	with	ADP
admet-535	32	17	the	the	DET
admet-535	32	18	biological	biological	ADJ
admet-535	32	19	target	target	NOUN
admet-535	32	20	(	(	PUNCT
admet-535	32	21	enzyme	enzyme	NOUN
admet-535	32	22	,	,	PUNCT
admet-535	32	23	receptor	receptor	NOUN
admet-535	32	24	)	)	PUNCT
admet-535	33	1	[	[	X
admet-535	33	2	7	7	NUM
admet-535	33	3	]	]	PUNCT
admet-535	33	4	.	.	PUNCT
admet-535	34	1	development	development	NOUN
admet-535	34	2	of	of	ADP
admet-535	34	3	target	target	NOUN
admet-535	34	4	-	-	PUNCT
admet-535	34	5	oriented	orient	VERB
admet-535	34	6	assays	assay	NOUN
admet-535	34	7	with	with	ADP
admet-535	34	8	immobilized	immobilized	ADJ
admet-535	34	9	functional	functional	ADJ
admet-535	34	10	enzymes	enzyme	NOUN
admet-535	34	11	has	have	AUX
admet-535	34	12	been	be	AUX
admet-535	34	13	more	more	ADV
admet-535	34	14	popular	popular	ADJ
admet-535	34	15	than	than	ADP
admet-535	34	16	the	the	DET
admet-535	34	17	attempts	attempt	NOUN
admet-535	34	18	to	to	PART
admet-535	34	19	design	design	VERB
admet-535	34	20	tests	test	NOUN
admet-535	34	21	aimed	aim	VERB
admet-535	34	22	at	at	ADP
admet-535	34	23	identification	identification	NOUN
admet-535	34	24	of	of	ADP
admet-535	34	25	compounds	compound	NOUN
admet-535	34	26	targeting	target	VERB
admet-535	34	27	cell	cell	NOUN
admet-535	34	28	membrane	membrane	NOUN
admet-535	34	29	proteins	protein	NOUN
admet-535	34	30	.	.	PUNCT
admet-535	35	1	cytosolic	cytosolic	ADJ
admet-535	35	2	proteins	protein	NOUN
admet-535	35	3	are	be	AUX
admet-535	35	4	usually	usually	ADV
admet-535	35	5	covalently	covalently	ADV
admet-535	35	6	bonded	bond	VERB
admet-535	35	7	using	use	VERB
admet-535	35	8	their	their	PRON
admet-535	35	9	nor	nor	CCONJ
admet-535	35	10	c	c	NOUN
admet-535	35	11	-	-	PUNCT
admet-535	35	12	terminus	terminus	NOUN
admet-535	35	13	groups	group	NOUN
admet-535	35	14	forming	form	VERB
admet-535	35	15	the	the	DET
admet-535	35	16	covalent	covalent	ADJ
admet-535	35	17	bond	bond	NOUN
admet-535	35	18	with	with	ADP
admet-535	35	19	chemical	chemical	ADJ
admet-535	35	20	moieties	moiety	NOUN
admet-535	35	21	on	on	ADP
admet-535	35	22	the	the	DET
admet-535	35	23	surface	surface	NOUN
admet-535	35	24	of	of	ADP
admet-535	35	25	the	the	DET
admet-535	35	26	assay	assay	NOUN
admet-535	35	27	scaffold	scaffold	NOUN
admet-535	35	28	,	,	PUNCT
admet-535	35	29	e.g.	e.g.	ADV
admet-535	35	30	the	the	DET
admet-535	35	31	inside	inside	NOUN
admet-535	35	32	of	of	ADP
admet-535	35	33	the	the	DET
admet-535	35	34	column	column	NOUN
admet-535	35	35	or	or	CCONJ
admet-535	35	36	magnetic	magnetic	ADJ
admet-535	35	37	beads	bead	NOUN
admet-535	35	38	[	[	X
admet-535	35	39	9	9	NUM
admet-535	35	40	,	,	PUNCT
admet-535	35	41	10	10	NUM
admet-535	35	42	]	]	PUNCT
admet-535	35	43	.	.	PUNCT
admet-535	36	1	many	many	ADJ
admet-535	36	2	natural	natural	ADJ
admet-535	36	3	compounds	compound	NOUN
admet-535	36	4	target	target	NOUN
admet-535	36	5	cell	cell	NOUN
admet-535	36	6	membrane	membrane	NOUN
admet-535	36	7	proteins	protein	NOUN
admet-535	36	8	but	but	CCONJ
admet-535	36	9	the	the	DET
admet-535	36	10	solutions	solution	NOUN
admet-535	36	11	developed	develop	VERB
admet-535	36	12	for	for	ADP
admet-535	36	13	cytosolic	cytosolic	ADJ
admet-535	36	14	proteins	protein	NOUN
admet-535	36	15	can	can	AUX
admet-535	36	16	not	not	PART
admet-535	36	17	be	be	AUX
admet-535	36	18	used	use	VERB
admet-535	36	19	to	to	PART
admet-535	36	20	immobilize	immobilize	VERB
admet-535	36	21	transmembrane	transmembrane	ADJ
admet-535	36	22	proteins	protein	NOUN
admet-535	36	23	[	[	X
admet-535	36	24	7	7	NUM
admet-535	36	25	]	]	PUNCT
admet-535	36	26	.	.	PUNCT
admet-535	37	1	this	this	DET
admet-535	37	2	review	review	NOUN
admet-535	37	3	focuses	focus	VERB
admet-535	37	4	on	on	ADP
admet-535	37	5	the	the	DET
admet-535	37	6	development	development	NOUN
admet-535	37	7	of	of	ADP
admet-535	37	8	novel	novel	ADJ
admet-535	37	9	bioassays	bioassay	NOUN
admet-535	37	10	with	with	ADP
admet-535	37	11	the	the	DET
admet-535	37	12	immobilized	immobilize	VERB
admet-535	37	13	fully	fully	ADV
admet-535	37	14	functional	functional	ADJ
admet-535	37	15	cell	cell	NOUN
admet-535	37	16	membrane	membrane	NOUN
admet-535	37	17	proteins	protein	NOUN
admet-535	37	18	and	and	CCONJ
admet-535	37	19	their	their	PRON
admet-535	37	20	use	use	NOUN
admet-535	37	21	in	in	ADP
admet-535	37	22	drug	drug	NOUN
admet-535	37	23	leads	lead	VERB
admet-535	37	24	discovery	discovery	NOUN
admet-535	37	25	from	from	ADP
admet-535	37	26	complex	complex	ADJ
admet-535	37	27	natural	natural	ADJ
admet-535	37	28	matrices	matrix	NOUN
admet-535	37	29	.	.	PUNCT
admet-535	38	1	one	one	NUM
admet-535	38	2	of	of	ADP
admet-535	38	3	the	the	DET
admet-535	38	4	most	most	ADV
admet-535	38	5	important	important	ADJ
admet-535	38	6	issues	issue	NOUN
admet-535	38	7	in	in	ADP
admet-535	38	8	developing	develop	VERB
admet-535	38	9	assays	assay	NOUN
admet-535	38	10	targeting	target	VERB
admet-535	38	11	transmembrane	transmembrane	ADJ
admet-535	38	12	receptors	receptor	NOUN
admet-535	38	13	is	be	AUX
admet-535	38	14	to	to	PART
admet-535	38	15	make	make	VERB
admet-535	38	16	sure	sure	ADJ
admet-535	38	17	functional	functional	ADJ
admet-535	38	18	protein	protein	NOUN
admet-535	38	19	is	be	AUX
admet-535	38	20	immobilized	immobilize	VERB
admet-535	38	21	.	.	PUNCT
admet-535	39	1	introducing	introduce	VERB
admet-535	39	2	chemical	chemical	NOUN
admet-535	39	3	changes	change	NOUN
admet-535	39	4	in	in	ADP
admet-535	39	5	the	the	DET
admet-535	39	6	immobilization	immobilization	NOUN
admet-535	39	7	process	process	NOUN
admet-535	39	8	of	of	ADP
admet-535	39	9	enzymes	enzyme	NOUN
admet-535	39	10	may	may	AUX
admet-535	39	11	lead	lead	VERB
admet-535	39	12	to	to	ADP
admet-535	39	13	irreversible	irreversible	ADJ
admet-535	39	14	modifications	modification	NOUN
admet-535	39	15	to	to	ADP
admet-535	39	16	protein	protein	NOUN
admet-535	39	17	structure	structure	NOUN
admet-535	39	18	and	and	CCONJ
admet-535	39	19	result	result	VERB
admet-535	39	20	in	in	ADP
admet-535	39	21	failure	failure	NOUN
admet-535	39	22	to	to	PART
admet-535	39	23	develop	develop	VERB
admet-535	39	24	functional	functional	ADJ
admet-535	39	25	assay	assay	NOUN
admet-535	39	26	[	[	X
admet-535	39	27	11	11	NUM
admet-535	39	28	]	]	PUNCT
admet-535	39	29	.	.	PUNCT
admet-535	40	1	it	it	PRON
admet-535	40	2	is	be	AUX
admet-535	40	3	important	important	ADJ
admet-535	40	4	to	to	PART
admet-535	40	5	keep	keep	VERB
admet-535	40	6	boundary	boundary	ADJ
admet-535	40	7	lipids	lipid	NOUN
admet-535	40	8	surrounding	surround	VERB
admet-535	40	9	the	the	DET
admet-535	40	10	transmembrane	transmembrane	ADJ
admet-535	40	11	protein	protein	NOUN
admet-535	40	12	intact	intact	ADJ
admet-535	40	13	as	as	ADP
admet-535	40	14	the	the	DET
admet-535	40	15	subtle	subtle	ADJ
admet-535	40	16	interactions	interaction	NOUN
admet-535	40	17	between	between	ADP
admet-535	40	18	transmembrane	transmembrane	ADJ
admet-535	40	19	domains	domain	NOUN
admet-535	40	20	and	and	CCONJ
admet-535	40	21	these	these	DET
admet-535	40	22	lipids	lipids	ADJ
admet-535	40	23	influences	influence	NOUN
admet-535	40	24	how	how	SCONJ
admet-535	40	25	the	the	DET
admet-535	40	26	potential	potential	ADJ
admet-535	40	27	ligands	ligand	NOUN
admet-535	40	28	bind	bind	VERB
admet-535	40	29	to	to	ADP
admet-535	40	30	the	the	DET
admet-535	40	31	protein	protein	NOUN
admet-535	40	32	.	.	PUNCT
admet-535	41	1	it	it	PRON
admet-535	41	2	must	must	AUX
admet-535	41	3	be	be	AUX
admet-535	41	4	remembered	remember	VERB
admet-535	41	5	that	that	SCONJ
admet-535	41	6	in	in	ADP
admet-535	41	7	the	the	DET
admet-535	41	8	process	process	NOUN
admet-535	41	9	of	of	ADP
admet-535	41	10	transmembrane	transmembrane	ADJ
admet-535	41	11	protein	protein	NOUN
admet-535	41	12	immobilization	immobilization	NOUN
admet-535	41	13	,	,	PUNCT
admet-535	41	14	the	the	DET
admet-535	41	15	cell	cell	NOUN
admet-535	41	16	membrane	membrane	NOUN
admet-535	41	17	fragments	fragment	NOUN
admet-535	41	18	and	and	CCONJ
admet-535	41	19	not	not	PART
admet-535	41	20	the	the	DET
admet-535	41	21	pure	pure	ADJ
admet-535	41	22	proteins	protein	NOUN
admet-535	41	23	are	be	AUX
admet-535	41	24	immobilized	immobilize	VERB
admet-535	41	25	[	[	PUNCT
admet-535	41	26	7	7	NUM
admet-535	41	27	]	]	PUNCT
admet-535	41	28	.	.	PUNCT
admet-535	42	1	stripping	strip	VERB
admet-535	42	2	off	off	ADP
admet-535	42	3	the	the	DET
admet-535	42	4	boundary	boundary	ADJ
admet-535	42	5	lipids	lipid	NOUN
admet-535	42	6	would	would	AUX
admet-535	42	7	not	not	PART
admet-535	42	8	only	only	ADV
admet-535	42	9	lead	lead	VERB
admet-535	42	10	to	to	ADP
admet-535	42	11	changing	change	VERB
admet-535	42	12	the	the	DET
admet-535	42	13	receptor	receptor	NOUN
admet-535	42	14	binding	bind	VERB
admet-535	42	15	activity	activity	NOUN
admet-535	42	16	but	but	CCONJ
admet-535	42	17	also	also	ADV
admet-535	42	18	would	would	AUX
admet-535	42	19	probably	probably	ADV
admet-535	42	20	result	result	VERB
admet-535	42	21	in	in	ADP
admet-535	42	22	the	the	DET
admet-535	42	23	immobilization	immobilization	NOUN
admet-535	42	24	of	of	ADP
admet-535	42	25	protein	protein	NOUN
admet-535	42	26	aggregates	aggregate	NOUN
admet-535	42	27	,	,	PUNCT
admet-535	42	28	that	that	PRON
admet-535	42	29	would	would	AUX
admet-535	42	30	form	form	VERB
admet-535	42	31	during	during	ADP
admet-535	42	32	the	the	DET
admet-535	42	33	cayman	cayman	NOUN
admet-535	42	34	,	,	PUNCT
admet-535	42	35	omri	omri	PROPN
admet-535	42	36	&	&	CCONJ
admet-535	42	37	ciesla	ciesla	PROPN
admet-535	42	38	admet	admet	PROPN
admet-535	42	39	&	&	CCONJ
admet-535	42	40	dmpk	dmpk	PROPN
admet-535	42	41	6(3	6(3	PROPN
admet-535	42	42	)	)	PUNCT
admet-535	42	43	(	(	PUNCT
admet-535	42	44	2018	2018	NUM
admet-535	42	45	)	)	PUNCT
admet-535	42	46	200	200	NUM
admet-535	42	47	-	-	SYM
admet-535	42	48	214	214	NUM
admet-535	42	49	202	202	NUM
admet-535	42	50	immobilization	immobilization	NOUN
admet-535	42	51	process	process	NOUN
admet-535	42	52	[	[	X
admet-535	42	53	11	11	NUM
admet-535	42	54	]	]	PUNCT
admet-535	42	55	.	.	PUNCT
admet-535	43	1	the	the	DET
admet-535	43	2	aggregates	aggregate	NOUN
admet-535	43	3	would	would	AUX
admet-535	43	4	develop	develop	VERB
admet-535	43	5	because	because	SCONJ
admet-535	43	6	nonpolar	nonpolar	ADJ
admet-535	43	7	amino	amino	NOUN
admet-535	43	8	acid	acid	NOUN
admet-535	43	9	residues	residue	NOUN
admet-535	43	10	,	,	PUNCT
admet-535	43	11	forming	form	VERB
admet-535	43	12	the	the	DET
admet-535	43	13	transmembrane	transmembrane	NOUN
admet-535	43	14	domains	domain	NOUN
admet-535	43	15	would	would	AUX
admet-535	43	16	bury	bury	VERB
admet-535	43	17	in	in	ADP
admet-535	43	18	the	the	DET
admet-535	43	19	interior	interior	NOUN
admet-535	43	20	of	of	ADP
admet-535	43	21	the	the	DET
admet-535	43	22	aggregates	aggregate	NOUN
admet-535	43	23	not	not	PART
admet-535	43	24	to	to	PART
admet-535	43	25	get	get	AUX
admet-535	43	26	exposed	expose	VERB
admet-535	43	27	to	to	ADP
admet-535	43	28	an	an	DET
admet-535	43	29	aqueous	aqueous	ADJ
admet-535	43	30	environment	environment	NOUN
admet-535	43	31	.	.	PUNCT
admet-535	44	1	the	the	DET
admet-535	44	2	immobilization	immobilization	NOUN
admet-535	44	3	of	of	ADP
admet-535	44	4	cell	cell	NOUN
admet-535	44	5	membrane	membrane	NOUN
admet-535	44	6	fragments	fragment	NOUN
admet-535	44	7	with	with	ADP
admet-535	44	8	functional	functional	ADJ
admet-535	44	9	transmembrane	transmembrane	NOUN
admet-535	44	10	receptors	receptor	NOUN
admet-535	44	11	can	can	AUX
admet-535	44	12	be	be	AUX
admet-535	44	13	achieved	achieve	VERB
admet-535	44	14	in	in	ADP
admet-535	44	15	the	the	DET
admet-535	44	16	process	process	NOUN
admet-535	44	17	of	of	ADP
admet-535	44	18	cellular	cellular	ADJ
admet-535	44	19	membrane	membrane	NOUN
admet-535	44	20	affinity	affinity	NOUN
admet-535	44	21	chromatography	chromatography	NOUN
admet-535	44	22	(	(	PUNCT
admet-535	44	23	cmac	cmac	NOUN
admet-535	44	24	)	)	PUNCT
admet-535	44	25	column	column	NOUN
admet-535	44	26	preparation	preparation	NOUN
admet-535	45	1	[	[	X
admet-535	45	2	11	11	NUM
admet-535	45	3	]	]	PUNCT
admet-535	45	4	.	.	PUNCT
admet-535	46	1	successful	successful	ADJ
admet-535	46	2	immobilization	immobilization	NOUN
admet-535	46	3	of	of	ADP
admet-535	46	4	transmembrane	transmembrane	ADJ
admet-535	46	5	fragments	fragment	NOUN
admet-535	46	6	will	will	AUX
admet-535	46	7	result	result	VERB
admet-535	46	8	in	in	ADP
admet-535	46	9	obtaining	obtain	VERB
admet-535	46	10	an	an	DET
admet-535	46	11	assay	assay	NOUN
admet-535	46	12	that	that	PRON
admet-535	46	13	enables	enable	VERB
admet-535	46	14	the	the	DET
admet-535	46	15	study	study	NOUN
admet-535	46	16	of	of	ADP
admet-535	46	17	ligand	ligand	NOUN
admet-535	46	18	-	-	PUNCT
admet-535	46	19	receptor	receptor	NOUN
admet-535	46	20	interactions	interaction	NOUN
admet-535	46	21	in	in	ADP
admet-535	46	22	close	close	ADJ
admet-535	46	23	to	to	ADP
admet-535	46	24	physiological	physiological	ADJ
admet-535	46	25	conditions	condition	NOUN
admet-535	46	26	(	(	PUNCT
admet-535	46	27	figure	figure	NOUN
admet-535	46	28	1	1	NUM
admet-535	46	29	)	)	PUNCT
admet-535	46	30	.	.	PUNCT
admet-535	47	1	cellular	cellular	ADJ
admet-535	47	2	membrane	membrane	NOUN
admet-535	47	3	affinity	affinity	NOUN
admet-535	47	4	chromatography	chromatography	NOUN
admet-535	47	5	columns	column	NOUN
admet-535	47	6	–	–	PUNCT
admet-535	47	7	a	a	DET
admet-535	47	8	short	short	ADJ
admet-535	47	9	historical	historical	ADJ
admet-535	47	10	perspective	perspective	NOUN
admet-535	47	11	to	to	ADP
admet-535	47	12	the	the	DET
admet-535	47	13	best	good	ADJ
admet-535	47	14	of	of	ADP
admet-535	47	15	our	our	PRON
admet-535	47	16	knowledge	knowledge	NOUN
admet-535	47	17	,	,	PUNCT
admet-535	47	18	lundahl	lundahl	PROPN
admet-535	47	19	’s	’s	PART
admet-535	47	20	group	group	NOUN
admet-535	47	21	was	be	AUX
admet-535	47	22	the	the	DET
admet-535	47	23	first	first	ADJ
admet-535	47	24	to	to	PART
admet-535	47	25	successfully	successfully	ADV
admet-535	47	26	immobilize	immobilize	VERB
admet-535	47	27	transmembrane	transmembrane	ADJ
admet-535	47	28	protein	protein	NOUN
admet-535	47	29	,	,	PUNCT
admet-535	47	30	the	the	DET
admet-535	47	31	glucose	glucose	NOUN
admet-535	47	32	transporter	transporter	NOUN
admet-535	47	33	,	,	PUNCT
admet-535	47	34	glut	glut	VERB
admet-535	47	35	1	1	NUM
admet-535	48	1	[	[	X
admet-535	48	2	12	12	NUM
admet-535	48	3	]	]	PUNCT
admet-535	48	4	.	.	PUNCT
admet-535	49	1	this	this	DET
admet-535	49	2	study	study	NOUN
admet-535	49	3	stimulated	stimulate	VERB
admet-535	49	4	wainer	wainer	NOUN
admet-535	49	5	’s	’s	PART
admet-535	49	6	group	group	NOUN
admet-535	49	7	to	to	PART
admet-535	49	8	approach	approach	VERB
admet-535	49	9	the	the	DET
admet-535	49	10	immobilization	immobilization	NOUN
admet-535	49	11	process	process	NOUN
admet-535	49	12	of	of	ADP
admet-535	49	13	nicotinic	nicotinic	ADJ
admet-535	49	14	acetylcholine	acetylcholine	NOUN
admet-535	49	15	receptors	receptor	NOUN
admet-535	49	16	(	(	PUNCT
admet-535	49	17	nachrs	nachrs	ADV
admet-535	49	18	)	)	PUNCT
admet-535	49	19	on	on	ADP
admet-535	49	20	lipid	lipid	ADJ
admet-535	49	21	monolayers	monolayer	NOUN
admet-535	49	22	[	[	X
admet-535	49	23	13	13	NUM
admet-535	49	24	]	]	PUNCT
admet-535	49	25	.	.	PUNCT
admet-535	50	1	interestingly	interestingly	ADV
admet-535	50	2	α3β4	α3β4	PRON
admet-535	50	3	nachrs	nachrs	ADJ
admet-535	50	4	were	be	AUX
admet-535	50	5	also	also	ADV
admet-535	50	6	successfully	successfully	ADV
admet-535	50	7	immobilized	immobilize	VERB
admet-535	50	8	on	on	ADP
admet-535	50	9	the	the	DET
admet-535	50	10	immobilized	immobilized	ADJ
admet-535	50	11	artificial	artificial	ADJ
admet-535	50	12	membrane	membrane	NOUN
admet-535	50	13	(	(	PUNCT
admet-535	50	14	iam	iam	PROPN
admet-535	50	15	)	)	PUNCT
admet-535	50	16	stationary	stationary	ADJ
admet-535	50	17	phase	phase	NOUN
admet-535	50	18	,	,	PUNCT
admet-535	50	19	developed	develop	VERB
admet-535	50	20	by	by	ADP
admet-535	50	21	pidgeon	pidgeon	NOUN
admet-535	50	22	et	et	PROPN
admet-535	50	23	al	al	PROPN
admet-535	50	24	.	.	PUNCT
admet-535	51	1	[	[	X
admet-535	51	2	14	14	NUM
admet-535	51	3	]	]	PUNCT
admet-535	51	4	and	and	CCONJ
admet-535	51	5	currently	currently	ADV
admet-535	51	6	available	available	ADJ
admet-535	51	7	from	from	ADP
admet-535	51	8	regis	regis	PROPN
admet-535	51	9	technologies	technology	NOUN
admet-535	51	10	,	,	PUNCT
admet-535	51	11	figure	figure	NOUN
admet-535	51	12	2	2	NUM
admet-535	51	13	.	.	PUNCT
admet-535	51	14	figure	figure	NOUN
admet-535	51	15	1	1	NUM
admet-535	51	16	.	.	PUNCT
admet-535	51	17	cellular	cellular	ADJ
admet-535	51	18	membrane	membrane	NOUN
admet-535	51	19	affinity	affinity	NOUN
admet-535	51	20	chromatography	chromatography	NOUN
admet-535	51	21	column	column	NOUN
admet-535	51	22	contains	contain	VERB
admet-535	51	23	cell	cell	NOUN
admet-535	51	24	membrane	membrane	NOUN
admet-535	51	25	fragments	fragment	NOUN
admet-535	51	26	with	with	ADP
admet-535	51	27	fully	fully	ADV
admet-535	51	28	functional	functional	ADJ
admet-535	51	29	transmembrane	transmembrane	ADJ
admet-535	51	30	protein	protein	NOUN
admet-535	51	31	(	(	PUNCT
admet-535	51	32	tpm	tpm	NOUN
admet-535	51	33	)	)	PUNCT
admet-535	51	34	targets	target	NOUN
admet-535	51	35	and	and	CCONJ
admet-535	51	36	therefore	therefore	ADV
admet-535	51	37	allows	allow	VERB
admet-535	51	38	for	for	ADP
admet-535	51	39	studying	study	VERB
admet-535	51	40	the	the	DET
admet-535	51	41	interactions	interaction	NOUN
admet-535	51	42	between	between	ADP
admet-535	51	43	small	small	ADJ
admet-535	51	44	molecules	molecule	NOUN
admet-535	51	45	and	and	CCONJ
admet-535	51	46	tmp	tmp	VERB
admet-535	51	47	in	in	ADP
admet-535	51	48	close	close	ADV
admet-535	51	49	to	to	ADP
admet-535	51	50	physiological	physiological	ADJ
admet-535	51	51	conditions	condition	NOUN
admet-535	51	52	studies	study	NOUN
admet-535	51	53	by	by	ADP
admet-535	51	54	the	the	DET
admet-535	51	55	wainer	wainer	NOUN
admet-535	51	56	group	group	NOUN
admet-535	51	57	showed	show	VERB
admet-535	51	58	that	that	SCONJ
admet-535	51	59	cmac	cmac	NOUN
admet-535	51	60	prepared	prepare	VERB
admet-535	51	61	with	with	ADP
admet-535	51	62	the	the	DET
admet-535	51	63	use	use	NOUN
admet-535	51	64	of	of	ADP
admet-535	51	65	iam	iam	PROPN
admet-535	51	66	particles	particle	NOUN
admet-535	51	67	were	be	AUX
admet-535	51	68	characterized	characterize	VERB
admet-535	51	69	by	by	ADP
admet-535	51	70	better	well	ADJ
admet-535	51	71	reproducibility	reproducibility	NOUN
admet-535	51	72	compared	compare	VERB
admet-535	51	73	to	to	ADP
admet-535	51	74	liposomal	liposomal	ADJ
admet-535	51	75	columns	column	NOUN
admet-535	51	76	[	[	X
admet-535	51	77	13	13	NUM
admet-535	51	78	]	]	PUNCT
admet-535	51	79	.	.	PUNCT
admet-535	52	1	since	since	SCONJ
admet-535	52	2	the	the	DET
admet-535	52	3	successful	successful	ADJ
admet-535	52	4	immobilization	immobilization	NOUN
admet-535	52	5	of	of	ADP
admet-535	52	6	nachrs	nachrs	ADJ
admet-535	52	7	on	on	ADP
admet-535	52	8	the	the	DET
admet-535	52	9	iam	iam	PROPN
admet-535	52	10	stationary	stationary	ADJ
admet-535	52	11	phase	phase	NOUN
admet-535	52	12	,	,	PUNCT
admet-535	52	13	multiple	multiple	ADJ
admet-535	52	14	transmembrane	transmembrane	ADJ
admet-535	52	15	proteins	protein	NOUN
admet-535	52	16	have	have	AUX
admet-535	52	17	been	be	AUX
admet-535	52	18	used	use	VERB
admet-535	52	19	to	to	PART
admet-535	52	20	prepare	prepare	VERB
admet-535	52	21	cmacs	cmac	NOUN
admet-535	52	22	with	with	ADP
admet-535	52	23	iam.pc	iam.pc	PROPN
admet-535	52	24	(	(	PUNCT
admet-535	52	25	immobilized	immobilize	VERB
admet-535	52	26	artificial	artificial	ADJ
admet-535	52	27	membrane	membrane	NOUN
admet-535	52	28	phosphatidylcholine	phosphatidylcholine	NOUN
admet-535	52	29	)	)	PUNCT
admet-535	52	30	.	.	PUNCT
admet-535	53	1	the	the	DET
admet-535	53	2	examples	example	NOUN
admet-535	53	3	of	of	ADP
admet-535	53	4	transmembrane	transmembrane	ADJ
admet-535	53	5	proteins	protein	NOUN
admet-535	53	6	immobilized	immobilize	VERB
admet-535	53	7	on	on	ADP
admet-535	53	8	iam.pc	iam.pc	PROPN
admet-535	53	9	particles	particle	NOUN
admet-535	53	10	include	include	VERB
admet-535	53	11	:	:	PUNCT
admet-535	53	12	ligand	ligand	NOUN
admet-535	53	13	-	-	PUNCT
admet-535	53	14	gated	gate	VERB
admet-535	53	15	ion	ion	NOUN
admet-535	53	16	channels	channel	NOUN
admet-535	53	17	(	(	PUNCT
admet-535	53	18	xy	xy	NOUN
admet-535	53	19	nachr	nachr	NOUN
admet-535	53	20	x	x	PUNCT
admet-535	54	1	=	=	SYM
admet-535	54	2	3,4,7	3,4,7	NUM
admet-535	54	3	;	;	PUNCT
admet-535	54	4	y	y	PROPN
admet-535	54	5	=	=	SYM
admet-535	54	6	2,3,4	2,3,4	NUM
admet-535	54	7	;	;	PUNCT
admet-535	54	8	gabaa	gabaa	NOUN
admet-535	54	9	,	,	PUNCT
admet-535	54	10	nmda	nmda	ADJ
admet-535	54	11	,	,	PUNCT
admet-535	54	12	combination	combination	NOUN
admet-535	54	13	of	of	ADP
admet-535	54	14	nachr	nachr	PROPN
admet-535	54	15	,	,	PUNCT
admet-535	54	16	nmda	nmda	ADJ
admet-535	54	17	)	)	PUNCT
admet-535	55	1	[	[	X
admet-535	55	2	11	11	NUM
admet-535	55	3	,	,	PUNCT
admet-535	55	4	13	13	NUM
admet-535	55	5	,	,	PUNCT
admet-535	55	6	15	15	NUM
admet-535	55	7	-	-	SYM
admet-535	55	8	30	30	NUM
admet-535	55	9	]	]	PUNCT
admet-535	55	10	,	,	PUNCT
admet-535	55	11	g	g	NOUN
admet-535	55	12	-	-	PUNCT
admet-535	55	13	protein	protein	NOUN
admet-535	55	14	coupled	couple	VERB
admet-535	55	15	receptors	receptor	NOUN
admet-535	55	16	(	(	PUNCT
admet-535	55	17	opioid	opioid	ADJ
admet-535	55	18	,	,	PUNCT
admet-535	55	19	-adrenergic	-adrenergic	PROPN
admet-535	55	20	,	,	PUNCT
admet-535	55	21	p2y1	p2y1	ADV
admet-535	55	22	,	,	PUNCT
admet-535	55	23	histamine	histamine	NOUN
admet-535	55	24	1	1	NUM
admet-535	55	25	-	-	SYM
admet-535	55	26	4	4	NUM
admet-535	55	27	,	,	PUNCT
admet-535	55	28	cb1	cb1	NOUN
admet-535	55	29	,	,	PUNCT
admet-535	55	30	cb2	cb2	PROPN
admet-535	55	31	)	)	PUNCT
admet-535	56	1	[	[	X
admet-535	56	2	31	31	NUM
admet-535	56	3	-	-	SYM
admet-535	56	4	35	35	NUM
admet-535	56	5	]	]	PUNCT
admet-535	56	6	and	and	CCONJ
admet-535	56	7	drug	drug	NOUN
admet-535	56	8	transporters	transporter	NOUN
admet-535	56	9	(	(	PUNCT
admet-535	56	10	abc	abc	PROPN
admet-535	56	11	:	:	PUNCT
admet-535	56	12	pgp	pgp	NOUN
admet-535	56	13	,	,	PUNCT
admet-535	56	14	mrp1	mrp1	PROPN
admet-535	56	15	,	,	PUNCT
admet-535	56	16	mrp2	mrp2	PROPN
admet-535	56	17	,	,	PUNCT
admet-535	56	18	bcrp	bcrp	ADV
admet-535	56	19	;	;	PUNCT
admet-535	56	20	slc	slc	PROPN
admet-535	56	21	:	:	PUNCT
admet-535	56	22	hoct	hoct	PROPN
admet-535	56	23	and	and	CCONJ
admet-535	56	24	hoct	hoct	PROPN
admet-535	56	25	snps	snps	PROPN
admet-535	56	26	,	,	PUNCT
admet-535	56	27	hoat	hoat	NOUN
admet-535	56	28	)	)	PUNCT
admet-535	57	1	[	[	X
admet-535	57	2	36	36	NUM
admet-535	57	3	-	-	SYM
admet-535	57	4	39	39	NUM
admet-535	57	5	]	]	PUNCT
admet-535	57	6	.	.	PUNCT
admet-535	58	1	iam.pc	iam.pc	PROPN
admet-535	58	2	mimics	mimic	VERB
admet-535	58	3	the	the	DET
admet-535	58	4	cell	cell	NOUN
admet-535	58	5	membrane	membrane	NOUN
admet-535	58	6	environment	environment	NOUN
admet-535	58	7	and	and	CCONJ
admet-535	58	8	keeps	keep	VERB
admet-535	58	9	the	the	DET
admet-535	58	10	experimental	experimental	ADJ
admet-535	58	11	conditions	condition	NOUN
admet-535	58	12	close	close	ADJ
admet-535	58	13	to	to	ADP
admet-535	58	14	the	the	DET
admet-535	58	15	physiological	physiological	ADJ
admet-535	58	16	state	state	NOUN
admet-535	58	17	.	.	PUNCT
admet-535	59	1	the	the	DET
admet-535	59	2	surface	surface	NOUN
admet-535	59	3	of	of	ADP
admet-535	59	4	the	the	DET
admet-535	59	5	iam.pc	iam.pc	PROPN
admet-535	59	6	stationary	stationary	ADJ
admet-535	59	7	phase	phase	NOUN
admet-535	59	8	still	still	ADV
admet-535	59	9	contains	contain	VERB
admet-535	59	10	residual	residual	ADJ
admet-535	59	11	silanol	silanol	NOUN
admet-535	59	12	and	and	CCONJ
admet-535	59	13	amine	amine	ADJ
admet-535	59	14	groups	group	NOUN
admet-535	59	15	on	on	ADP
admet-535	59	16	its	its	PRON
admet-535	59	17	surface	surface	NOUN
admet-535	59	18	,	,	PUNCT
admet-535	59	19	which	which	PRON
admet-535	59	20	may	may	AUX
admet-535	59	21	become	become	AUX
admet-535	59	22	charged	charge	VERB
admet-535	59	23	during	during	ADP
admet-535	59	24	the	the	DET
admet-535	59	25	analysis	analysis	NOUN
admet-535	59	26	,	,	PUNCT
admet-535	59	27	resulting	result	VERB
admet-535	59	28	in	in	ADP
admet-535	59	29	changed	change	VERB
admet-535	59	30	retention	retention	NOUN
admet-535	59	31	parameters	parameter	NOUN
admet-535	59	32	of	of	ADP
admet-535	59	33	the	the	DET
admet-535	59	34	studied	study	VERB
admet-535	59	35	ligands	ligand	NOUN
admet-535	59	36	.	.	PUNCT
admet-535	60	1	a	a	DET
admet-535	60	2	new	new	ADJ
admet-535	60	3	class	class	NOUN
admet-535	60	4	of	of	ADP
admet-535	60	5	stationary	stationary	ADJ
admet-535	60	6	phase	phase	NOUN
admet-535	60	7	has	have	AUX
admet-535	60	8	been	be	AUX
admet-535	60	9	developed	develop	VERB
admet-535	60	10	by	by	ADP
admet-535	60	11	regis	regis	PROPN
admet-535	60	12	,	,	PUNCT
admet-535	60	13	iam.pc.dd2	iam.pc.dd2	PROPN
admet-535	60	14	particles	particle	VERB
admet-535	60	15	with	with	ADP
admet-535	60	16	amine	amine	ADJ
admet-535	60	17	groups	group	NOUN
admet-535	60	18	endcapped	endcappe	VERB
admet-535	60	19	,	,	PUNCT
admet-535	60	20	figure	figure	NOUN
admet-535	60	21	2	2	NUM
admet-535	60	22	.	.	PUNCT
admet-535	61	1	the	the	DET
admet-535	61	2	endcapping	endcapping	NOUN
admet-535	61	3	leads	lead	VERB
admet-535	61	4	to	to	ADP
admet-535	61	5	an	an	DET
admet-535	61	6	increase	increase	NOUN
admet-535	61	7	of	of	ADP
admet-535	61	8	the	the	DET
admet-535	61	9	stationary	stationary	ADJ
admet-535	61	10	phase	phase	NOUN
admet-535	61	11	stability	stability	NOUN
admet-535	61	12	and	and	CCONJ
admet-535	61	13	its	its	PRON
admet-535	61	14	lipophilicity	lipophilicity	NOUN
admet-535	61	15	.	.	PUNCT
admet-535	62	1	to	to	ADP
admet-535	62	2	the	the	DET
admet-535	62	3	best	good	ADJ
admet-535	62	4	of	of	ADP
admet-535	62	5	our	our	PRON
admet-535	62	6	knowledge	knowledge	NOUN
admet-535	62	7	,	,	PUNCT
admet-535	62	8	there	there	PRON
admet-535	62	9	are	be	VERB
admet-535	62	10	no	no	DET
admet-535	62	11	data	datum	NOUN
admet-535	62	12	available	available	ADJ
admet-535	62	13	on	on	ADP
admet-535	62	14	the	the	DET
admet-535	62	15	possible	possible	ADJ
admet-535	62	16	use	use	NOUN
admet-535	62	17	of	of	ADP
admet-535	62	18	iam.pc.dd2	iam.pc.dd2	PROPN
admet-535	62	19	particles	particle	NOUN
admet-535	62	20	in	in	ADP
admet-535	62	21	the	the	DET
admet-535	62	22	preparation	preparation	NOUN
admet-535	62	23	of	of	ADP
admet-535	62	24	cmacs	cmacs	PROPN
admet-535	62	25	.	.	PUNCT
admet-535	63	1	future	future	ADJ
admet-535	63	2	experiments	experiment	NOUN
admet-535	63	3	should	should	AUX
admet-535	63	4	determine	determine	VERB
admet-535	63	5	whether	whether	SCONJ
admet-535	63	6	endcapping	endcappe	VERB
admet-535	63	7	the	the	DET
admet-535	63	8	residual	residual	ADJ
admet-535	63	9	amine	amine	ADJ
admet-535	63	10	and	and	CCONJ
admet-535	63	11	silanol	silanol	NOUN
admet-535	63	12	groups	group	NOUN
admet-535	63	13	would	would	AUX
admet-535	63	14	result	result	VERB
admet-535	63	15	in	in	ADP
admet-535	63	16	more	more	ADV
admet-535	63	17	reproducible	reproducible	ADJ
admet-535	63	18	data	datum	NOUN
admet-535	63	19	generated	generate	VERB
admet-535	63	20	with	with	ADP
admet-535	63	21	cmacs	cmac	NOUN
admet-535	63	22	.	.	PUNCT
admet-535	64	1	possible	possible	ADJ
admet-535	64	2	problems	problem	NOUN
admet-535	64	3	with	with	ADP
admet-535	64	4	the	the	DET
admet-535	64	5	use	use	NOUN
admet-535	64	6	of	of	ADP
admet-535	64	7	more	more	ADJ
admet-535	64	8	lipophilic	lipophilic	ADJ
admet-535	64	9	artificial	artificial	ADJ
admet-535	64	10	membrane	membrane	NOUN
admet-535	64	11	particles	particle	NOUN
admet-535	64	12	are	be	AUX
admet-535	64	13	discussed	discuss	VERB
admet-535	64	14	further	far	ADV
admet-535	64	15	in	in	ADP
admet-535	64	16	this	this	DET
admet-535	64	17	review	review	NOUN
admet-535	64	18	.	.	PUNCT
admet-535	65	1	admet	admet	PROPN
admet-535	65	2	&	&	CCONJ
admet-535	65	3	dmpk	dmpk	PROPN
admet-535	65	4	6(3	6(3	PROPN
admet-535	65	5	)	)	PUNCT
admet-535	65	6	(	(	PUNCT
admet-535	65	7	2018	2018	NUM
admet-535	65	8	)	)	PUNCT
admet-535	65	9	200	200	NUM
admet-535	65	10	-	-	SYM
admet-535	65	11	214	214	NUM
admet-535	65	12	cell	cell	NOUN
admet-535	65	13	membrane	membrane	NOUN
admet-535	65	14	affinity	affinity	NOUN
admet-535	65	15	chromatography	chromatography	NOUN
admet-535	65	16	in	in	ADP
admet-535	65	17	drug	drug	NOUN
admet-535	65	18	discovery	discovery	NOUN
admet-535	65	19	doi	doi	PROPN
admet-535	65	20	:	:	PUNCT
admet-535	65	21	10.5599	10.5599	NUM
admet-535	65	22	/	/	SYM
admet-535	65	23	admet.535	admet.535	PROPN
admet-535	65	24	203	203	NUM
admet-535	65	25	figure	figure	NOUN
admet-535	65	26	2	2	NUM
admet-535	65	27	.	.	PUNCT
admet-535	65	28	differences	difference	NOUN
admet-535	65	29	in	in	ADP
admet-535	65	30	surface	surface	NOUN
admet-535	65	31	chemistry	chemistry	NOUN
admet-535	65	32	of	of	ADP
admet-535	65	33	iam.pc	iam.pc	PROPN
admet-535	65	34	and	and	CCONJ
admet-535	65	35	iam.pc.dd2	iam.pc.dd2	PROPN
admet-535	65	36	particles	particle	NOUN
admet-535	65	37	.	.	PUNCT
admet-535	66	1	with	with	ADP
admet-535	66	2	permission	permission	NOUN
admet-535	66	3	from	from	ADP
admet-535	66	4	regis	regis	PROPN
admet-535	66	5	technologies	technology	NOUN
admet-535	66	6	another	another	DET
admet-535	66	7	approach	approach	NOUN
admet-535	66	8	developed	develop	VERB
admet-535	66	9	to	to	PART
admet-535	66	10	study	study	VERB
admet-535	66	11	ligand	ligand	ADJ
admet-535	66	12	-	-	PUNCT
admet-535	66	13	protein	protein	NOUN
admet-535	66	14	interactions	interaction	NOUN
admet-535	66	15	involves	involve	VERB
admet-535	66	16	the	the	DET
admet-535	66	17	use	use	NOUN
admet-535	66	18	of	of	ADP
admet-535	66	19	activated	activate	VERB
admet-535	66	20	silica	silica	NOUN
admet-535	66	21	for	for	ADP
admet-535	66	22	the	the	DET
admet-535	66	23	adsorption	adsorption	NOUN
admet-535	66	24	of	of	ADP
admet-535	66	25	cell	cell	NOUN
admet-535	66	26	membrane	membrane	NOUN
admet-535	66	27	fragments	fragment	NOUN
admet-535	66	28	and	and	CCONJ
admet-535	66	29	is	be	AUX
admet-535	66	30	called	call	VERB
admet-535	66	31	cell	cell	NOUN
admet-535	66	32	membrane	membrane	NOUN
admet-535	66	33	chromatography	chromatography	NOUN
admet-535	66	34	(	(	PUNCT
admet-535	66	35	cmc	cmc	PROPN
admet-535	66	36	)	)	PUNCT
admet-535	67	1	[	[	X
admet-535	67	2	40	40	NUM
admet-535	67	3	]	]	PUNCT
admet-535	67	4	.	.	PUNCT
admet-535	68	1	the	the	DET
admet-535	68	2	use	use	NOUN
admet-535	68	3	of	of	ADP
admet-535	68	4	silica	silica	NOUN
admet-535	68	5	introduces	introduce	NOUN
admet-535	68	6	silica	silica	NOUN
admet-535	68	7	groups	group	NOUN
admet-535	68	8	in	in	ADP
admet-535	68	9	the	the	DET
admet-535	68	10	process	process	NOUN
admet-535	68	11	of	of	ADP
admet-535	68	12	studying	study	VERB
admet-535	68	13	ligand	ligand	NOUN
admet-535	68	14	-	-	PUNCT
admet-535	68	15	protein	protein	NOUN
admet-535	68	16	interactions	interaction	NOUN
admet-535	68	17	,	,	PUNCT
admet-535	68	18	which	which	PRON
admet-535	68	19	does	do	AUX
admet-535	68	20	not	not	PART
admet-535	68	21	closely	closely	ADV
admet-535	68	22	resemble	resemble	VERB
admet-535	68	23	physiological	physiological	ADJ
admet-535	68	24	conditions	condition	NOUN
admet-535	68	25	.	.	PUNCT
admet-535	69	1	however	however	ADV
admet-535	69	2	,	,	PUNCT
admet-535	69	3	numerous	numerous	ADJ
admet-535	69	4	drug	drug	NOUN
admet-535	69	5	discovery	discovery	NOUN
admet-535	69	6	approaches	approach	NOUN
admet-535	69	7	utilizing	utilize	VERB
admet-535	69	8	cmcs	cmcs	ADV
admet-535	69	9	have	have	AUX
admet-535	69	10	been	be	AUX
admet-535	69	11	reported	report	VERB
admet-535	69	12	in	in	ADP
admet-535	69	13	the	the	DET
admet-535	69	14	literature	literature	NOUN
admet-535	69	15	,	,	PUNCT
admet-535	69	16	for	for	ADP
admet-535	69	17	example	example	NOUN
admet-535	69	18	[	[	X
admet-535	69	19	40	40	NUM
admet-535	69	20	-	-	SYM
admet-535	69	21	43	43	NUM
admet-535	69	22	]	]	PUNCT
admet-535	69	23	.	.	PUNCT
admet-535	70	1	this	this	DET
admet-535	70	2	review	review	NOUN
admet-535	70	3	purely	purely	ADV
admet-535	70	4	focuses	focus	VERB
admet-535	70	5	on	on	ADP
admet-535	70	6	the	the	DET
admet-535	70	7	approach	approach	NOUN
admet-535	70	8	with	with	ADP
admet-535	70	9	the	the	DET
admet-535	70	10	artificial	artificial	ADJ
admet-535	70	11	membrane	membrane	NOUN
admet-535	70	12	as	as	ADP
admet-535	70	13	the	the	DET
admet-535	70	14	support	support	NOUN
admet-535	70	15	for	for	ADP
admet-535	70	16	the	the	DET
admet-535	70	17	adsorbing	adsorb	VERB
admet-535	70	18	cell	cell	NOUN
admet-535	70	19	membrane	membrane	NOUN
admet-535	70	20	fragments	fragment	NOUN
admet-535	70	21	and	and	CCONJ
admet-535	70	22	therefore	therefore	ADV
admet-535	70	23	cmc	cmc	NOUN
admet-535	70	24	is	be	AUX
admet-535	70	25	not	not	PART
admet-535	70	26	further	far	ADV
admet-535	70	27	discussed	discuss	VERB
admet-535	70	28	in	in	ADP
admet-535	70	29	this	this	DET
admet-535	70	30	paper	paper	NOUN
admet-535	70	31	.	.	PUNCT
admet-535	71	1	preparation	preparation	NOUN
admet-535	71	2	steps	step	NOUN
admet-535	71	3	of	of	ADP
admet-535	71	4	cellular	cellular	ADJ
admet-535	71	5	membrane	membrane	NOUN
admet-535	71	6	affinity	affinity	NOUN
admet-535	71	7	chromatography	chromatography	NOUN
admet-535	71	8	columns	column	VERB
admet-535	71	9	the	the	DET
admet-535	71	10	process	process	NOUN
admet-535	71	11	of	of	ADP
admet-535	71	12	preparing	prepare	VERB
admet-535	71	13	cmac	cmac	NOUN
admet-535	71	14	columns	column	NOUN
admet-535	71	15	has	have	AUX
admet-535	71	16	been	be	AUX
admet-535	71	17	described	describe	VERB
admet-535	71	18	in	in	ADP
admet-535	71	19	detail	detail	NOUN
admet-535	71	20	elsewhere	elsewhere	ADV
admet-535	71	21	by	by	ADP
admet-535	71	22	moaddel	moaddel	NOUN
admet-535	71	23	and	and	CCONJ
admet-535	71	24	wainer	wainer	VERB
admet-535	72	1	[	[	X
admet-535	72	2	11	11	NUM
admet-535	72	3	]	]	PUNCT
admet-535	72	4	.	.	PUNCT
admet-535	73	1	in	in	ADP
admet-535	73	2	this	this	DET
admet-535	73	3	review	review	NOUN
admet-535	73	4	,	,	PUNCT
admet-535	73	5	critical	critical	ADJ
admet-535	73	6	steps	step	NOUN
admet-535	73	7	of	of	ADP
admet-535	73	8	column	column	NOUN
admet-535	73	9	preparation	preparation	NOUN
admet-535	73	10	are	be	AUX
admet-535	73	11	described	describe	VERB
admet-535	73	12	and	and	CCONJ
admet-535	73	13	particular	particular	ADJ
admet-535	73	14	attention	attention	NOUN
admet-535	73	15	is	be	AUX
admet-535	73	16	paid	pay	VERB
admet-535	73	17	to	to	ADP
admet-535	73	18	issues	issue	NOUN
admet-535	73	19	that	that	PRON
admet-535	73	20	have	have	VERB
admet-535	73	21	the	the	DET
admet-535	73	22	most	most	ADV
admet-535	73	23	critical	critical	ADJ
admet-535	73	24	impact	impact	NOUN
admet-535	73	25	on	on	ADP
admet-535	73	26	the	the	DET
admet-535	73	27	process	process	NOUN
admet-535	73	28	of	of	ADP
admet-535	73	29	developing	develop	VERB
admet-535	73	30	a	a	DET
admet-535	73	31	functional	functional	ADJ
admet-535	73	32	cmac	cmac	NOUN
admet-535	73	33	.	.	PUNCT
admet-535	74	1	the	the	DET
admet-535	74	2	process	process	NOUN
admet-535	74	3	of	of	ADP
admet-535	74	4	cmac	cmac	NOUN
admet-535	74	5	development	development	NOUN
admet-535	74	6	can	can	AUX
admet-535	74	7	be	be	AUX
admet-535	74	8	divided	divide	VERB
admet-535	74	9	into	into	ADP
admet-535	74	10	5	5	NUM
admet-535	74	11	consecutive	consecutive	ADJ
admet-535	74	12	steps	step	NOUN
admet-535	74	13	:	:	PUNCT
admet-535	74	14	(	(	PUNCT
admet-535	74	15	1	1	X
admet-535	74	16	)	)	PUNCT
admet-535	74	17	transmembrane	transmembrane	ADJ
admet-535	74	18	protein	protein	NOUN
admet-535	74	19	source	source	NOUN
admet-535	74	20	cell	cell	NOUN
admet-535	74	21	/	/	SYM
admet-535	74	22	tissue	tissue	NOUN
admet-535	74	23	homogenization	homogenization	NOUN
admet-535	74	24	,	,	PUNCT
admet-535	74	25	(	(	PUNCT
admet-535	74	26	2	2	NUM
admet-535	74	27	)	)	PUNCT
admet-535	74	28	solubilization	solubilization	NOUN
admet-535	74	29	,	,	PUNCT
admet-535	74	30	(	(	PUNCT
admet-535	74	31	3	3	X
admet-535	74	32	)	)	PUNCT
admet-535	74	33	dialysis	dialysis	NOUN
admet-535	74	34	and	and	CCONJ
admet-535	74	35	immobilization	immobilization	NOUN
admet-535	74	36	,	,	PUNCT
admet-535	74	37	(	(	PUNCT
admet-535	74	38	4	4	X
admet-535	74	39	)	)	PUNCT
admet-535	74	40	packing	packing	NOUN
admet-535	74	41	and	and	CCONJ
admet-535	74	42	(	(	PUNCT
admet-535	74	43	5	5	NUM
admet-535	74	44	)	)	PUNCT
admet-535	74	45	column	column	NOUN
admet-535	74	46	characterization	characterization	NOUN
admet-535	74	47	(	(	PUNCT
admet-535	74	48	figure	figure	NOUN
admet-535	74	49	3	3	NUM
admet-535	74	50	)	)	PUNCT
admet-535	74	51	.	.	PUNCT
admet-535	75	1	homogenization	homogenization	NOUN
admet-535	75	2	the	the	DET
admet-535	75	3	first	first	ADJ
admet-535	75	4	step	step	NOUN
admet-535	75	5	in	in	ADP
admet-535	75	6	preparing	prepare	VERB
admet-535	75	7	a	a	DET
admet-535	75	8	cmac	cmac	NOUN
admet-535	75	9	column	column	NOUN
admet-535	75	10	is	be	AUX
admet-535	75	11	the	the	DET
admet-535	75	12	choice	choice	NOUN
admet-535	75	13	of	of	ADP
admet-535	75	14	transmembrane	transmembrane	ADJ
admet-535	75	15	protein	protein	NOUN
admet-535	75	16	source	source	NOUN
admet-535	75	17	(	(	PUNCT
admet-535	75	18	cell	cell	NOUN
admet-535	75	19	line	line	NOUN
admet-535	75	20	or	or	CCONJ
admet-535	75	21	tissue	tissue	NOUN
admet-535	75	22	)	)	PUNCT
admet-535	75	23	.	.	PUNCT
admet-535	76	1	if	if	SCONJ
admet-535	76	2	cmac	cmac	NOUN
admet-535	76	3	is	be	AUX
admet-535	76	4	to	to	PART
admet-535	76	5	be	be	AUX
admet-535	76	6	used	use	VERB
admet-535	76	7	in	in	ADP
admet-535	76	8	the	the	DET
admet-535	76	9	drug	drug	NOUN
admet-535	76	10	discovery	discovery	NOUN
admet-535	76	11	screening	screening	NOUN
admet-535	76	12	process	process	NOUN
admet-535	76	13	of	of	ADP
admet-535	76	14	complex	complex	ADJ
admet-535	76	15	natural	natural	ADJ
admet-535	76	16	matrices	matrix	NOUN
admet-535	76	17	then	then	ADV
admet-535	76	18	the	the	DET
admet-535	76	19	use	use	NOUN
admet-535	76	20	of	of	ADP
admet-535	76	21	transfected	transfecte	VERB
admet-535	76	22	cell	cell	NOUN
admet-535	76	23	line	line	NOUN
admet-535	76	24	overexpressing	overexpresse	VERB
admet-535	76	25	the	the	DET
admet-535	76	26	transmembrane	transmembrane	ADJ
admet-535	76	27	protein	protein	NOUN
admet-535	76	28	of	of	ADP
admet-535	76	29	choice	choice	NOUN
admet-535	76	30	is	be	AUX
admet-535	76	31	recommended	recommend	VERB
admet-535	76	32	.	.	PUNCT
admet-535	77	1	a	a	DET
admet-535	77	2	cmac	cmac	NOUN
admet-535	77	3	column	column	NOUN
admet-535	77	4	prepared	prepare	VERB
admet-535	77	5	with	with	ADP
admet-535	77	6	a	a	DET
admet-535	77	7	transfected	transfecte	VERB
admet-535	77	8	cell	cell	NOUN
admet-535	77	9	line	line	NOUN
admet-535	77	10	will	will	AUX
admet-535	77	11	result	result	VERB
admet-535	77	12	in	in	ADP
admet-535	77	13	a	a	DET
admet-535	77	14	higher	high	ADJ
admet-535	77	15	number	number	NOUN
admet-535	77	16	of	of	ADP
admet-535	77	17	active	active	ADJ
admet-535	77	18	sites	site	NOUN
admet-535	77	19	increasing	increase	VERB
admet-535	77	20	the	the	DET
admet-535	77	21	capacity	capacity	NOUN
admet-535	77	22	and	and	CCONJ
admet-535	77	23	selectivity	selectivity	NOUN
admet-535	77	24	of	of	ADP
admet-535	77	25	the	the	DET
admet-535	77	26	new	new	ADJ
admet-535	77	27	column	column	NOUN
admet-535	77	28	[	[	X
admet-535	77	29	11	11	NUM
admet-535	77	30	]	]	PUNCT
admet-535	77	31	.	.	PUNCT
admet-535	78	1	however	however	ADV
admet-535	78	2	,	,	PUNCT
admet-535	78	3	if	if	SCONJ
admet-535	78	4	the	the	DET
admet-535	78	5	experiments	experiment	NOUN
admet-535	78	6	using	use	VERB
admet-535	78	7	cmac	cmac	NOUN
admet-535	78	8	focus	focus	NOUN
admet-535	78	9	on	on	ADP
admet-535	78	10	the	the	DET
admet-535	78	11	characterization	characterization	NOUN
admet-535	78	12	of	of	ADP
admet-535	78	13	transmembrane	transmembrane	ADJ
admet-535	78	14	protein	protein	NOUN
admet-535	78	15	and	and	CCONJ
admet-535	78	16	its	its	PRON
admet-535	78	17	interaction	interaction	NOUN
admet-535	78	18	with	with	ADP
admet-535	78	19	particular	particular	ADJ
admet-535	78	20	ligands	ligand	NOUN
admet-535	78	21	,	,	PUNCT
admet-535	78	22	the	the	DET
admet-535	78	23	use	use	NOUN
admet-535	78	24	of	of	ADP
admet-535	78	25	a	a	DET
admet-535	78	26	native	native	ADJ
admet-535	78	27	cell	cell	NOUN
admet-535	78	28	line	line	NOUN
admet-535	78	29	is	be	AUX
admet-535	78	30	advised	advise	VERB
admet-535	78	31	.	.	PUNCT
admet-535	79	1	the	the	DET
admet-535	79	2	use	use	NOUN
admet-535	79	3	of	of	ADP
admet-535	79	4	native	native	ADJ
admet-535	79	5	cell	cell	NOUN
admet-535	79	6	line	line	NOUN
admet-535	79	7	guarantees	guarantee	VERB
admet-535	79	8	that	that	SCONJ
admet-535	79	9	the	the	DET
admet-535	79	10	studied	study	VERB
admet-535	79	11	protein	protein	NOUN
admet-535	79	12	is	be	AUX
admet-535	79	13	surrounded	surround	VERB
admet-535	79	14	by	by	ADP
admet-535	79	15	the	the	DET
admet-535	79	16	boundary	boundary	ADJ
admet-535	79	17	lipids	lipid	NOUN
admet-535	79	18	that	that	PRON
admet-535	79	19	assure	assure	VERB
admet-535	79	20	its	its	PRON
admet-535	79	21	full	full	ADJ
admet-535	79	22	natural	natural	ADJ
admet-535	79	23	functionality	functionality	NOUN
admet-535	79	24	.	.	PUNCT
admet-535	80	1	in	in	ADP
admet-535	80	2	native	native	ADJ
admet-535	80	3	cell	cell	NOUN
admet-535	80	4	lines	line	NOUN
admet-535	80	5	,	,	PUNCT
admet-535	80	6	transmembrane	transmembrane	ADJ
admet-535	80	7	proteins	protein	NOUN
admet-535	80	8	also	also	ADV
admet-535	80	9	cayman	cayman	NOUN
admet-535	80	10	,	,	PUNCT
admet-535	80	11	omri	omri	PROPN
admet-535	80	12	&	&	CCONJ
admet-535	80	13	ciesla	ciesla	PROPN
admet-535	80	14	admet	admet	PROPN
admet-535	80	15	&	&	CCONJ
admet-535	80	16	dmpk	dmpk	PROPN
admet-535	80	17	6(3	6(3	PROPN
admet-535	80	18	)	)	PUNCT
admet-535	80	19	(	(	PUNCT
admet-535	80	20	2018	2018	NUM
admet-535	80	21	)	)	PUNCT
admet-535	80	22	200	200	NUM
admet-535	80	23	-	-	SYM
admet-535	80	24	214	214	NUM
admet-535	80	25	204	204	NUM
admet-535	80	26	may	may	AUX
admet-535	80	27	undergo	undergo	VERB
admet-535	80	28	some	some	DET
admet-535	80	29	specific	specific	ADJ
admet-535	80	30	post	post	ADJ
admet-535	80	31	-	-	ADJ
admet-535	80	32	translational	translational	ADJ
admet-535	80	33	modifications	modification	NOUN
admet-535	80	34	that	that	PRON
admet-535	80	35	may	may	AUX
admet-535	80	36	not	not	PART
admet-535	80	37	take	take	VERB
admet-535	80	38	place	place	NOUN
admet-535	80	39	in	in	ADP
admet-535	80	40	the	the	DET
admet-535	80	41	case	case	NOUN
admet-535	80	42	of	of	ADP
admet-535	80	43	a	a	DET
admet-535	80	44	transfected	transfecte	VERB
admet-535	80	45	cell	cell	NOUN
admet-535	80	46	line	line	NOUN
admet-535	80	47	.	.	PUNCT
admet-535	81	1	figure	figure	NOUN
admet-535	81	2	3	3	NUM
admet-535	81	3	.	.	PUNCT
admet-535	82	1	preparation	preparation	NOUN
admet-535	82	2	steps	step	NOUN
admet-535	82	3	of	of	ADP
admet-535	82	4	cell	cell	NOUN
admet-535	82	5	membrane	membrane	NOUN
admet-535	82	6	affinity	affinity	NOUN
admet-535	82	7	chromatography	chromatography	NOUN
admet-535	82	8	columns	column	NOUN
admet-535	82	9	(	(	PUNCT
admet-535	82	10	cmac	cmac	PROPN
admet-535	82	11	)	)	PUNCT
admet-535	82	12	the	the	DET
admet-535	82	13	homogenization	homogenization	NOUN
admet-535	82	14	process	process	NOUN
admet-535	82	15	is	be	AUX
admet-535	82	16	performed	perform	VERB
admet-535	82	17	in	in	ADP
admet-535	82	18	a	a	DET
admet-535	82	19	buffered	buffer	VERB
admet-535	82	20	environment	environment	NOUN
admet-535	82	21	(	(	PUNCT
admet-535	82	22	usually	usually	ADV
admet-535	82	23	tris	tris	ADJ
admet-535	82	24	-hcl	-hcl	ADJ
admet-535	82	25	buffer	buffer	NOUN
admet-535	82	26	,	,	PUNCT
admet-535	82	27	50	50	NUM
admet-535	82	28	mm	mm	NOUN
admet-535	82	29	,	,	PUNCT
admet-535	82	30	ph	ph	NOUN
admet-535	82	31	7.4	7.4	NUM
admet-535	82	32	)	)	PUNCT
admet-535	82	33	with	with	ADP
admet-535	82	34	the	the	DET
admet-535	82	35	addition	addition	NOUN
admet-535	82	36	of	of	ADP
admet-535	82	37	salts	salt	NOUN
admet-535	82	38	,	,	PUNCT
admet-535	82	39	to	to	PART
admet-535	82	40	keep	keep	VERB
admet-535	82	41	it	it	PRON
admet-535	82	42	close	close	ADJ
admet-535	82	43	to	to	ADP
admet-535	82	44	physiological	physiological	ADJ
admet-535	82	45	conditions	condition	NOUN
admet-535	82	46	and	and	CCONJ
admet-535	82	47	protect	protect	VERB
admet-535	82	48	the	the	DET
admet-535	82	49	transmembrane	transmembrane	ADJ
admet-535	82	50	protein	protein	NOUN
admet-535	82	51	from	from	ADP
admet-535	82	52	degradation	degradation	NOUN
admet-535	82	53	.	.	PUNCT
admet-535	83	1	the	the	DET
admet-535	83	2	homogenization	homogenization	NOUN
admet-535	83	3	procedures	procedure	NOUN
admet-535	83	4	are	be	AUX
admet-535	83	5	performed	perform	VERB
admet-535	83	6	on	on	ADP
admet-535	83	7	ice	ice	NOUN
admet-535	83	8	and	and	CCONJ
admet-535	83	9	all	all	DET
admet-535	83	10	centrifugation	centrifugation	NOUN
admet-535	83	11	steps	step	NOUN
admet-535	83	12	are	be	AUX
admet-535	83	13	executed	execute	VERB
admet-535	83	14	at	at	ADP
admet-535	83	15	4	4	NUM
admet-535	83	16	°	°	NOUN
admet-535	83	17	c	c	NOUN
admet-535	83	18	.	.	PUNCT
admet-535	84	1	glass	glass	NOUN
admet-535	84	2	-	-	PUNCT
admet-535	84	3	dounce	dounce	NOUN
admet-535	84	4	homogenizers	homogenizer	NOUN
admet-535	84	5	,	,	PUNCT
admet-535	84	6	polytron	polytron	NOUN
admet-535	84	7	homogenizers	homogenizer	NOUN
admet-535	84	8	or	or	CCONJ
admet-535	84	9	sonicators	sonicator	NOUN
admet-535	84	10	are	be	AUX
admet-535	84	11	commonly	commonly	ADV
admet-535	84	12	used	use	VERB
admet-535	84	13	in	in	ADP
admet-535	84	14	the	the	DET
admet-535	84	15	process	process	NOUN
admet-535	84	16	of	of	ADP
admet-535	84	17	cell	cell	NOUN
admet-535	84	18	homogenization	homogenization	NOUN
admet-535	84	19	[	[	X
admet-535	84	20	11	11	NUM
admet-535	84	21	]	]	PUNCT
admet-535	84	22	.	.	PUNCT
admet-535	85	1	the	the	DET
admet-535	85	2	use	use	NOUN
admet-535	85	3	of	of	ADP
admet-535	85	4	protease	protease	NOUN
admet-535	85	5	and	and	CCONJ
admet-535	85	6	peptidase	peptidase	NOUN
admet-535	85	7	inhibitors	inhibitor	NOUN
admet-535	85	8	is	be	AUX
admet-535	85	9	required	require	VERB
admet-535	85	10	to	to	PART
admet-535	85	11	immobilize	immobilize	VERB
admet-535	85	12	functional	functional	ADJ
admet-535	85	13	transmembrane	transmembrane	ADJ
admet-535	85	14	protein	protein	NOUN
admet-535	85	15	.	.	PUNCT
admet-535	86	1	the	the	DET
admet-535	86	2	choice	choice	NOUN
admet-535	86	3	of	of	ADP
admet-535	86	4	proper	proper	ADJ
admet-535	86	5	inhibitors	inhibitor	NOUN
admet-535	86	6	depends	depend	VERB
admet-535	86	7	on	on	ADP
admet-535	86	8	the	the	DET
admet-535	86	9	type	type	NOUN
admet-535	86	10	of	of	ADP
admet-535	86	11	cell	cell	NOUN
admet-535	86	12	line	line	NOUN
admet-535	86	13	used	use	VERB
admet-535	86	14	in	in	ADP
admet-535	86	15	the	the	DET
admet-535	86	16	experiments	experiment	NOUN
admet-535	86	17	.	.	PUNCT
admet-535	87	1	the	the	DET
admet-535	87	2	number	number	NOUN
admet-535	87	3	of	of	ADP
admet-535	87	4	cells	cell	NOUN
admet-535	87	5	used	use	VERB
admet-535	87	6	in	in	ADP
admet-535	87	7	the	the	DET
admet-535	87	8	experiment	experiment	NOUN
admet-535	87	9	depends	depend	VERB
admet-535	87	10	on	on	ADP
admet-535	87	11	the	the	DET
admet-535	87	12	level	level	NOUN
admet-535	87	13	of	of	ADP
admet-535	87	14	protein	protein	NOUN
admet-535	87	15	expression	expression	NOUN
admet-535	87	16	and	and	CCONJ
admet-535	87	17	may	may	AUX
admet-535	87	18	vary	vary	VERB
admet-535	87	19	from	from	ADP
admet-535	87	20	1	1	NUM
admet-535	87	21	million	million	NUM
admet-535	87	22	to	to	PART
admet-535	87	23	50	50	NUM
admet-535	87	24	million	million	NUM
admet-535	87	25	cells	cell	NOUN
admet-535	87	26	per	per	ADP
admet-535	87	27	pellet	pellet	NOUN
admet-535	87	28	.	.	PUNCT
admet-535	88	1	after	after	ADP
admet-535	88	2	rupturing	rupture	VERB
admet-535	88	3	the	the	DET
admet-535	88	4	cell	cell	NOUN
admet-535	88	5	structure	structure	NOUN
admet-535	88	6	,	,	PUNCT
admet-535	88	7	the	the	DET
admet-535	88	8	resulting	result	VERB
admet-535	88	9	homogenate	homogenate	NOUN
admet-535	88	10	is	be	AUX
admet-535	88	11	centrifuged	centrifuge	VERB
admet-535	88	12	at	at	ADP
admet-535	88	13	low	low	ADJ
admet-535	88	14	speed	speed	NOUN
admet-535	88	15	to	to	PART
admet-535	88	16	remove	remove	VERB
admet-535	88	17	nuclei	nucleus	NOUN
admet-535	88	18	and	and	CCONJ
admet-535	88	19	the	the	DET
admet-535	88	20	pellet	pellet	NOUN
admet-535	88	21	is	be	AUX
admet-535	88	22	discarded	discard	VERB
admet-535	88	23	.	.	PUNCT
admet-535	89	1	the	the	DET
admet-535	89	2	remaining	remain	VERB
admet-535	89	3	supernatant	supernatant	NOUN
admet-535	89	4	is	be	AUX
admet-535	89	5	subsequently	subsequently	ADV
admet-535	89	6	centrifuged	centrifuge	VERB
admet-535	89	7	at	at	ADP
admet-535	89	8	high	high	ADJ
admet-535	89	9	speed	speed	NOUN
admet-535	89	10	and	and	CCONJ
admet-535	89	11	the	the	DET
admet-535	89	12	pellet	pellet	NOUN
admet-535	89	13	containing	contain	VERB
admet-535	89	14	cell	cell	NOUN
admet-535	89	15	membranes	membrane	NOUN
admet-535	89	16	is	be	AUX
admet-535	89	17	collected	collect	VERB
admet-535	89	18	.	.	PUNCT
admet-535	90	1	in	in	ADP
admet-535	90	2	some	some	DET
admet-535	90	3	cases	case	NOUN
admet-535	90	4	,	,	PUNCT
admet-535	90	5	the	the	DET
admet-535	90	6	use	use	NOUN
admet-535	90	7	of	of	ADP
admet-535	90	8	additional	additional	ADJ
admet-535	90	9	reagents	reagent	NOUN
admet-535	90	10	is	be	AUX
admet-535	90	11	required	require	VERB
admet-535	90	12	for	for	ADP
admet-535	90	13	immobilization	immobilization	NOUN
admet-535	90	14	of	of	ADP
admet-535	90	15	functional	functional	ADJ
admet-535	90	16	protein	protein	NOUN
admet-535	90	17	.	.	PUNCT
admet-535	91	1	for	for	ADP
admet-535	91	2	example	example	NOUN
admet-535	91	3	,	,	PUNCT
admet-535	91	4	the	the	DET
admet-535	91	5	addition	addition	NOUN
admet-535	91	6	of	of	ADP
admet-535	91	7	glycerol	glycerol	NOUN
admet-535	91	8	enhances	enhance	VERB
admet-535	91	9	the	the	DET
admet-535	91	10	stability	stability	NOUN
admet-535	91	11	of	of	ADP
admet-535	91	12	the	the	DET
admet-535	91	13	protein	protein	NOUN
admet-535	91	14	in	in	ADP
admet-535	91	15	aqueous	aqueous	ADJ
admet-535	91	16	solutions	solution	NOUN
admet-535	91	17	and	and	CCONJ
admet-535	91	18	was	be	AUX
admet-535	91	19	found	find	VERB
admet-535	91	20	to	to	PART
admet-535	91	21	be	be	AUX
admet-535	91	22	useful	useful	ADJ
admet-535	91	23	in	in	ADP
admet-535	91	24	some	some	DET
admet-535	91	25	cmac	cmac	NOUN
admet-535	91	26	preparation	preparation	NOUN
admet-535	91	27	protocols	protocol	NOUN
admet-535	92	1	[	[	X
admet-535	92	2	11	11	NUM
admet-535	92	3	]	]	PUNCT
admet-535	92	4	.	.	PUNCT
admet-535	93	1	as	as	SCONJ
admet-535	93	2	previously	previously	ADV
admet-535	93	3	mentioned	mention	VERB
admet-535	93	4	the	the	DET
admet-535	93	5	interactions	interaction	NOUN
admet-535	93	6	of	of	ADP
admet-535	93	7	protein	protein	NOUN
admet-535	93	8	transmembrane	transmembrane	NOUN
admet-535	93	9	domains	domain	NOUN
admet-535	93	10	with	with	ADP
admet-535	93	11	boundary	boundary	ADJ
admet-535	93	12	lipids	lipids	ADJ
admet-535	93	13	influences	influence	NOUN
admet-535	93	14	the	the	DET
admet-535	93	15	activity	activity	NOUN
admet-535	93	16	of	of	ADP
admet-535	93	17	the	the	DET
admet-535	93	18	protein	protein	NOUN
admet-535	93	19	.	.	PUNCT
admet-535	94	1	the	the	DET
admet-535	94	2	addition	addition	NOUN
admet-535	94	3	of	of	ADP
admet-535	94	4	some	some	DET
admet-535	94	5	phospholipids	phospholipid	NOUN
admet-535	94	6	in	in	ADP
admet-535	94	7	the	the	DET
admet-535	94	8	buffer	buffer	NOUN
admet-535	94	9	solutions	solution	NOUN
admet-535	94	10	may	may	AUX
admet-535	94	11	be	be	AUX
admet-535	94	12	required	require	VERB
admet-535	94	13	in	in	ADP
admet-535	94	14	some	some	DET
admet-535	94	15	instances	instance	NOUN
admet-535	94	16	,	,	PUNCT
admet-535	94	17	as	as	SCONJ
admet-535	94	18	previously	previously	ADV
admet-535	94	19	reported	report	VERB
admet-535	94	20	[	[	X
admet-535	94	21	11	11	NUM
admet-535	94	22	]	]	PUNCT
admet-535	94	23	.	.	PUNCT
admet-535	95	1	for	for	ADP
admet-535	95	2	more	more	ADJ
admet-535	95	3	experimental	experimental	ADJ
admet-535	95	4	details	detail	NOUN
admet-535	95	5	please	please	INTJ
admet-535	95	6	refer	refer	VERB
admet-535	95	7	to	to	ADP
admet-535	95	8	the	the	DET
admet-535	95	9	manuscript	manuscript	NOUN
admet-535	95	10	by	by	ADP
admet-535	95	11	moaddel	moaddel	NOUN
admet-535	95	12	and	and	CCONJ
admet-535	95	13	wainer	wainer	VERB
admet-535	96	1	[	[	X
admet-535	96	2	11	11	NUM
admet-535	96	3	]	]	PUNCT
admet-535	96	4	.	.	PUNCT
admet-535	97	1	solubilization	solubilization	NOUN
admet-535	97	2	the	the	DET
admet-535	97	3	protein	protein	NOUN
admet-535	97	4	isolation	isolation	NOUN
admet-535	97	5	is	be	AUX
admet-535	97	6	completed	complete	VERB
admet-535	97	7	using	use	VERB
admet-535	97	8	the	the	DET
admet-535	97	9	solubilization	solubilization	NOUN
admet-535	97	10	step	step	NOUN
admet-535	97	11	.	.	PUNCT
admet-535	98	1	as	as	ADP
admet-535	98	2	in	in	ADP
admet-535	98	3	the	the	DET
admet-535	98	4	previous	previous	ADJ
admet-535	98	5	homogenization	homogenization	NOUN
admet-535	98	6	stage	stage	NOUN
admet-535	98	7	,	,	PUNCT
admet-535	98	8	all	all	DET
admet-535	98	9	the	the	DET
admet-535	98	10	experiments	experiment	NOUN
admet-535	98	11	are	be	AUX
admet-535	98	12	performed	perform	VERB
admet-535	98	13	at	at	ADP
admet-535	98	14	low	low	ADJ
admet-535	98	15	temperature	temperature	NOUN
admet-535	98	16	(	(	PUNCT
admet-535	98	17	4	4	NOUN
admet-535	98	18	°	°	NOUN
admet-535	98	19	c	c	NOUN
admet-535	98	20	)	)	PUNCT
admet-535	98	21	in	in	ADP
admet-535	98	22	a	a	DET
admet-535	98	23	buffered	buffer	VERB
admet-535	98	24	environment	environment	NOUN
admet-535	98	25	.	.	PUNCT
admet-535	99	1	compared	compare	VERB
admet-535	99	2	to	to	ADP
admet-535	99	3	the	the	DET
admet-535	99	4	homogenization	homogenization	NOUN
admet-535	99	5	buffer	buffer	NOUN
admet-535	99	6	,	,	PUNCT
admet-535	99	7	used	use	VERB
admet-535	99	8	in	in	ADP
admet-535	99	9	step	step	NOUN
admet-535	99	10	1	1	NUM
admet-535	99	11	,	,	PUNCT
admet-535	99	12	solubilization	solubilization	NOUN
admet-535	99	13	buffer	buffer	NOUN
admet-535	99	14	contains	contain	VERB
admet-535	99	15	detergent	detergent	NOUN
admet-535	99	16	,	,	PUNCT
admet-535	99	17	that	that	PRON
admet-535	99	18	solubilizes	solubilize	VERB
admet-535	99	19	transmembrane	transmembrane	ADJ
admet-535	99	20	proteins	protein	NOUN
admet-535	99	21	by	by	ADP
admet-535	99	22	forming	form	VERB
admet-535	99	23	micelles	micelle	NOUN
admet-535	99	24	around	around	ADP
admet-535	99	25	them	they	PRON
admet-535	99	26	.	.	PUNCT
admet-535	100	1	several	several	ADJ
admet-535	100	2	parameters	parameter	NOUN
admet-535	100	3	need	need	VERB
admet-535	100	4	to	to	PART
admet-535	100	5	be	be	AUX
admet-535	100	6	considered	consider	VERB
admet-535	100	7	when	when	SCONJ
admet-535	100	8	choosing	choose	VERB
admet-535	100	9	the	the	DET
admet-535	100	10	detergent	detergent	NOUN
admet-535	100	11	.	.	PUNCT
admet-535	101	1	again	again	ADV
admet-535	101	2	,	,	PUNCT
admet-535	101	3	it	it	PRON
admet-535	101	4	is	be	AUX
admet-535	101	5	of	of	ADP
admet-535	101	6	crucial	crucial	ADJ
admet-535	101	7	importance	importance	NOUN
admet-535	101	8	to	to	PART
admet-535	101	9	remember	remember	VERB
admet-535	101	10	that	that	SCONJ
admet-535	101	11	the	the	DET
admet-535	101	12	goal	goal	NOUN
admet-535	101	13	is	be	AUX
admet-535	101	14	to	to	PART
admet-535	101	15	immobilize	immobilize	VERB
admet-535	101	16	cell	cell	NOUN
admet-535	101	17	membrane	membrane	NOUN
admet-535	101	18	fragments	fragment	NOUN
admet-535	101	19	with	with	ADP
admet-535	101	20	transmembrane	transmembrane	ADJ
admet-535	101	21	proteins	protein	NOUN
admet-535	101	22	and	and	CCONJ
admet-535	101	23	not	not	PART
admet-535	101	24	the	the	DET
admet-535	101	25	purified	purified	ADJ
admet-535	101	26	proteins	protein	NOUN
admet-535	101	27	.	.	PUNCT
admet-535	102	1	the	the	DET
admet-535	102	2	use	use	NOUN
admet-535	102	3	of	of	ADP
admet-535	102	4	strong	strong	ADJ
admet-535	102	5	detergents	detergent	NOUN
admet-535	102	6	,	,	PUNCT
admet-535	102	7	like	like	ADP
admet-535	102	8	tween	tween	NOUN
admet-535	102	9	or	or	CCONJ
admet-535	102	10	triton	triton	PROPN
admet-535	102	11	x-100	x-100	PROPN
admet-535	102	12	,	,	PUNCT
admet-535	102	13	should	should	AUX
admet-535	102	14	be	be	AUX
admet-535	102	15	avoided	avoid	VERB
admet-535	102	16	as	as	SCONJ
admet-535	102	17	it	it	PRON
admet-535	102	18	may	may	AUX
admet-535	102	19	lead	lead	VERB
admet-535	102	20	to	to	ADP
admet-535	102	21	stripping	strip	VERB
admet-535	102	22	off	off	ADP
admet-535	102	23	the	the	DET
admet-535	102	24	boundary	boundary	ADJ
admet-535	102	25	lipids	lipid	NOUN
admet-535	102	26	resulting	result	VERB
admet-535	102	27	in	in	ADP
admet-535	102	28	the	the	DET
admet-535	102	29	immobilization	immobilization	NOUN
admet-535	102	30	of	of	ADP
admet-535	102	31	nonactive	nonactive	ADJ
admet-535	102	32	proteins	protein	NOUN
admet-535	102	33	or	or	CCONJ
admet-535	102	34	protein	protein	NOUN
admet-535	102	35	aggregates	aggregate	NOUN
admet-535	102	36	.	.	PUNCT
admet-535	103	1	these	these	DET
admet-535	103	2	detergents	detergent	NOUN
admet-535	103	3	would	would	AUX
admet-535	103	4	also	also	ADV
admet-535	103	5	cause	cause	VERB
admet-535	103	6	problems	problem	NOUN
admet-535	103	7	in	in	ADP
admet-535	103	8	the	the	DET
admet-535	103	9	next	next	ADJ
admet-535	103	10	step	step	NOUN
admet-535	103	11	,	,	PUNCT
admet-535	103	12	that	that	PRON
admet-535	103	13	requires	require	VERB
admet-535	103	14	elimination	elimination	NOUN
admet-535	103	15	of	of	ADP
admet-535	103	16	the	the	DET
admet-535	103	17	detergent	detergent	NOUN
admet-535	103	18	,	,	PUNCT
admet-535	103	19	as	as	SCONJ
admet-535	103	20	they	they	PRON
admet-535	103	21	are	be	AUX
admet-535	103	22	difficult	difficult	ADJ
admet-535	103	23	to	to	PART
admet-535	103	24	admet	admet	PROPN
admet-535	103	25	&	&	CCONJ
admet-535	103	26	dmpk	dmpk	PROPN
admet-535	103	27	6(3	6(3	PROPN
admet-535	103	28	)	)	PUNCT
admet-535	103	29	(	(	PUNCT
admet-535	103	30	2018	2018	NUM
admet-535	103	31	)	)	PUNCT
admet-535	103	32	200	200	NUM
admet-535	103	33	-	-	SYM
admet-535	103	34	214	214	NUM
admet-535	103	35	cell	cell	NOUN
admet-535	103	36	membrane	membrane	NOUN
admet-535	103	37	affinity	affinity	NOUN
admet-535	103	38	chromatography	chromatography	NOUN
admet-535	103	39	in	in	ADP
admet-535	103	40	drug	drug	NOUN
admet-535	103	41	discovery	discovery	NOUN
admet-535	103	42	doi	doi	PROPN
admet-535	103	43	:	:	PUNCT
admet-535	103	44	10.5599	10.5599	NUM
admet-535	103	45	/	/	SYM
admet-535	103	46	admet.535	admet.535	PROPN
admet-535	103	47	205	205	NUM
admet-535	103	48	remove	remove	NOUN
admet-535	103	49	using	use	VERB
admet-535	103	50	dialysis	dialysis	NOUN
admet-535	103	51	.	.	PUNCT
admet-535	104	1	previous	previous	ADJ
admet-535	104	2	studies	study	NOUN
admet-535	104	3	have	have	AUX
admet-535	104	4	shown	show	VERB
admet-535	104	5	the	the	DET
admet-535	104	6	use	use	NOUN
admet-535	104	7	of	of	ADP
admet-535	104	8	the	the	DET
admet-535	104	9	following	follow	VERB
admet-535	104	10	detergents	detergent	NOUN
admet-535	104	11	results	result	VERB
admet-535	104	12	in	in	ADP
admet-535	104	13	the	the	DET
admet-535	104	14	immobilization	immobilization	NOUN
admet-535	104	15	of	of	ADP
admet-535	104	16	functional	functional	ADJ
admet-535	104	17	transmembrane	transmembrane	ADJ
admet-535	104	18	proteins	protein	NOUN
admet-535	104	19	:	:	PUNCT
admet-535	104	20	sodium	sodium	NOUN
admet-535	104	21	cholate	cholate	NOUN
admet-535	104	22	(	(	PUNCT
admet-535	104	23	optimal	optimal	ADJ
admet-535	104	24	for	for	ADP
admet-535	104	25	immobilization	immobilization	NOUN
admet-535	104	26	of	of	ADP
admet-535	104	27	ligand	ligand	NOUN
admet-535	104	28	-	-	PUNCT
admet-535	104	29	gated	gate	VERB
admet-535	104	30	ion	ion	NOUN
admet-535	104	31	channels	channel	NOUN
admet-535	104	32	)	)	PUNCT
admet-535	104	33	,	,	PUNCT
admet-535	104	34	chaps	chap	NOUN
admet-535	104	35	(	(	PUNCT
admet-535	104	36	works	work	VERB
admet-535	104	37	well	well	ADV
admet-535	104	38	with	with	ADP
admet-535	104	39	gpcrs	gpcrs	PROPN
admet-535	104	40	)	)	PUNCT
admet-535	104	41	,	,	PUNCT
admet-535	104	42	and	and	CCONJ
admet-535	104	43	β	β	X
admet-535	104	44	-	-	PUNCT
admet-535	104	45	octyl	octyl	VERB
admet-535	104	46	glucopyranoside	glucopyranoside	NOUN
admet-535	105	1	[	[	X
admet-535	105	2	11	11	NUM
admet-535	105	3	]	]	PUNCT
admet-535	105	4	.	.	PUNCT
admet-535	106	1	the	the	DET
admet-535	106	2	pellet	pellet	NOUN
admet-535	106	3	collected	collect	VERB
admet-535	106	4	after	after	ADP
admet-535	106	5	the	the	DET
admet-535	106	6	completion	completion	NOUN
admet-535	106	7	of	of	ADP
admet-535	106	8	the	the	DET
admet-535	106	9	homogenization	homogenization	NOUN
admet-535	106	10	step	step	NOUN
admet-535	106	11	is	be	AUX
admet-535	106	12	mixed	mix	VERB
admet-535	106	13	with	with	ADP
admet-535	106	14	the	the	DET
admet-535	106	15	solubilization	solubilization	NOUN
admet-535	106	16	buffer	buffer	NOUN
admet-535	106	17	and	and	CCONJ
admet-535	106	18	left	leave	VERB
admet-535	106	19	overnight	overnight	ADV
admet-535	106	20	on	on	ADP
admet-535	106	21	the	the	DET
admet-535	106	22	orbital	orbital	ADJ
admet-535	106	23	shaker	shaker	NOUN
admet-535	106	24	at	at	ADP
admet-535	106	25	a	a	DET
admet-535	106	26	temperature	temperature	NOUN
admet-535	106	27	of	of	ADP
admet-535	106	28	4	4	NUM
admet-535	106	29	°	°	NOUN
admet-535	106	30	c	c	NOUN
admet-535	106	31	.	.	PUNCT
admet-535	107	1	dialysis	dialysis	NOUN
admet-535	107	2	and	and	CCONJ
admet-535	107	3	immobilization	immobilization	NOUN
admet-535	107	4	after	after	ADP
admet-535	107	5	the	the	DET
admet-535	107	6	completion	completion	NOUN
admet-535	107	7	of	of	ADP
admet-535	107	8	the	the	DET
admet-535	107	9	overnight	overnight	ADJ
admet-535	107	10	solubilization	solubilization	NOUN
admet-535	107	11	step	step	NOUN
admet-535	107	12	,	,	PUNCT
admet-535	107	13	the	the	DET
admet-535	107	14	mixture	mixture	NOUN
admet-535	107	15	is	be	AUX
admet-535	107	16	centrifuged	centrifuge	VERB
admet-535	107	17	at	at	ADP
admet-535	107	18	high	high	ADJ
admet-535	107	19	speed	speed	NOUN
admet-535	107	20	and	and	CCONJ
admet-535	107	21	the	the	DET
admet-535	107	22	pellet	pellet	NOUN
admet-535	107	23	discarded	discard	VERB
admet-535	107	24	.	.	PUNCT
admet-535	108	1	at	at	ADP
admet-535	108	2	this	this	DET
admet-535	108	3	point	point	NOUN
admet-535	108	4	,	,	PUNCT
admet-535	108	5	the	the	DET
admet-535	108	6	cell	cell	NOUN
admet-535	108	7	membrane	membrane	NOUN
admet-535	108	8	fragments	fragment	NOUN
admet-535	108	9	are	be	AUX
admet-535	108	10	in	in	ADP
admet-535	108	11	the	the	DET
admet-535	108	12	supernatant	supernatant	NOUN
admet-535	108	13	“	"	PUNCT
admet-535	108	14	trapped	trap	VERB
admet-535	108	15	”	"	PUNCT
admet-535	108	16	in	in	ADP
admet-535	108	17	the	the	DET
admet-535	108	18	micelles	micelle	NOUN
admet-535	108	19	formed	form	VERB
admet-535	108	20	by	by	ADP
admet-535	108	21	the	the	DET
admet-535	108	22	detergent	detergent	NOUN
admet-535	108	23	.	.	PUNCT
admet-535	109	1	the	the	DET
admet-535	109	2	resulting	result	VERB
admet-535	109	3	supernatant	supernatant	NOUN
admet-535	109	4	is	be	AUX
admet-535	109	5	put	put	VERB
admet-535	109	6	in	in	ADP
admet-535	109	7	contact	contact	NOUN
admet-535	109	8	with	with	ADP
admet-535	109	9	iam.pc	iam.pc	PROPN
admet-535	109	10	particles	particle	NOUN
admet-535	109	11	and	and	CCONJ
admet-535	109	12	left	leave	VERB
admet-535	109	13	on	on	ADP
admet-535	109	14	the	the	DET
admet-535	109	15	orbital	orbital	ADJ
admet-535	109	16	shaker	shaker	NOUN
admet-535	109	17	for	for	ADP
admet-535	109	18	1	1	NUM
admet-535	109	19	hour	hour	NOUN
admet-535	109	20	.	.	PUNCT
admet-535	110	1	to	to	PART
admet-535	110	2	complete	complete	VERB
admet-535	110	3	the	the	DET
admet-535	110	4	process	process	NOUN
admet-535	110	5	of	of	ADP
admet-535	110	6	immobilization	immobilization	NOUN
admet-535	110	7	of	of	ADP
admet-535	110	8	the	the	DET
admet-535	110	9	cell	cell	NOUN
admet-535	110	10	membrane	membrane	NOUN
admet-535	110	11	fragments	fragment	NOUN
admet-535	110	12	on	on	ADP
admet-535	110	13	the	the	DET
admet-535	110	14	iam	iam	PROPN
admet-535	110	15	particles	particle	NOUN
admet-535	110	16	,	,	PUNCT
admet-535	110	17	the	the	DET
admet-535	110	18	mixture	mixture	NOUN
admet-535	110	19	containing	contain	VERB
admet-535	110	20	iam.pc	iam.pc	PROPN
admet-535	110	21	stationary	stationary	ADJ
admet-535	110	22	phase	phase	NOUN
admet-535	110	23	and	and	CCONJ
admet-535	110	24	micelles	micelle	NOUN
admet-535	110	25	are	be	AUX
admet-535	110	26	placed	place	VERB
admet-535	110	27	in	in	ADP
admet-535	110	28	dialysis	dialysis	NOUN
admet-535	110	29	tubing	tubing	NOUN
admet-535	110	30	and	and	CCONJ
admet-535	110	31	dialysed	dialyse	VERB
admet-535	110	32	for	for	ADP
admet-535	110	33	48	48	NUM
admet-535	110	34	hours	hour	NOUN
admet-535	110	35	,	,	PUNCT
admet-535	110	36	to	to	PART
admet-535	110	37	get	get	AUX
admet-535	110	38	rid	rid	VERB
admet-535	110	39	of	of	ADP
admet-535	110	40	the	the	DET
admet-535	110	41	detergent	detergent	NOUN
admet-535	110	42	.	.	PUNCT
admet-535	111	1	disruption	disruption	NOUN
admet-535	111	2	of	of	ADP
admet-535	111	3	micelles	micelle	NOUN
admet-535	111	4	results	result	NOUN
admet-535	111	5	in	in	ADP
admet-535	111	6	freeing	free	VERB
admet-535	111	7	the	the	DET
admet-535	111	8	cell	cell	NOUN
admet-535	111	9	membrane	membrane	NOUN
admet-535	111	10	fragments	fragment	NOUN
admet-535	111	11	and	and	CCONJ
admet-535	111	12	the	the	DET
admet-535	111	13	phospholipids	phospholipid	NOUN
admet-535	111	14	forming	form	VERB
admet-535	111	15	cellular	cellular	ADJ
admet-535	111	16	bilayer	bilayer	NOUN
admet-535	111	17	adsorb	adsorb	VERB
admet-535	111	18	on	on	ADP
admet-535	111	19	iam	iam	PROPN
admet-535	111	20	particles	particle	NOUN
admet-535	111	21	to	to	PART
admet-535	111	22	protect	protect	VERB
admet-535	111	23	lipophilic	lipophilic	ADJ
admet-535	111	24	carbon	carbon	NOUN
admet-535	111	25	tails	tail	NOUN
admet-535	111	26	from	from	ADP
admet-535	111	27	their	their	PRON
admet-535	111	28	exposure	exposure	NOUN
admet-535	111	29	to	to	ADP
admet-535	111	30	the	the	DET
admet-535	111	31	aqueous	aqueous	ADJ
admet-535	111	32	environment	environment	NOUN
admet-535	111	33	.	.	PUNCT
admet-535	112	1	packing	pack	VERB
admet-535	112	2	after	after	ADP
admet-535	112	3	completing	complete	VERB
admet-535	112	4	the	the	DET
admet-535	112	5	dialysis	dialysis	NOUN
admet-535	112	6	step	step	VERB
admet-535	112	7	the	the	DET
admet-535	112	8	content	content	NOUN
admet-535	112	9	of	of	ADP
admet-535	112	10	the	the	DET
admet-535	112	11	dialysis	dialysis	NOUN
admet-535	112	12	tubing	tubing	NOUN
admet-535	112	13	is	be	AUX
admet-535	112	14	centrifuged	centrifuge	VERB
admet-535	112	15	at	at	ADP
admet-535	112	16	low	low	ADJ
admet-535	112	17	speed	speed	NOUN
admet-535	112	18	and	and	CCONJ
admet-535	112	19	the	the	DET
admet-535	112	20	supernatant	supernatant	NOUN
admet-535	112	21	is	be	AUX
admet-535	112	22	discarded	discard	VERB
admet-535	112	23	.	.	PUNCT
admet-535	113	1	the	the	DET
admet-535	113	2	remaining	remain	VERB
admet-535	113	3	pellet	pellet	NOUN
admet-535	113	4	is	be	AUX
admet-535	113	5	washed	wash	VERB
admet-535	113	6	three	three	NUM
admet-535	113	7	times	time	NOUN
admet-535	113	8	with	with	ADP
admet-535	113	9	ammonium	ammonium	NOUN
admet-535	113	10	acetate	acetate	NOUN
admet-535	113	11	buffer	buffer	NOUN
admet-535	113	12	(	(	PUNCT
admet-535	113	13	10	10	NUM
admet-535	113	14	mm	mm	NOUN
admet-535	113	15	,	,	PUNCT
admet-535	113	16	ph	ph	NOUN
admet-535	113	17	7.4	7.4	NUM
admet-535	113	18	)	)	PUNCT
admet-535	113	19	.	.	PUNCT
admet-535	114	1	ammonium	ammonium	NOUN
admet-535	114	2	acetate	acetate	NOUN
admet-535	114	3	buffer	buffer	NOUN
admet-535	114	4	is	be	AUX
admet-535	114	5	used	use	VERB
admet-535	114	6	also	also	ADV
admet-535	114	7	as	as	ADP
admet-535	114	8	running	run	VERB
admet-535	114	9	buffer	buffer	NOUN
admet-535	114	10	,	,	PUNCT
admet-535	114	11	as	as	SCONJ
admet-535	114	12	it	it	PRON
admet-535	114	13	is	be	AUX
admet-535	114	14	compatible	compatible	ADJ
admet-535	114	15	with	with	ADP
admet-535	114	16	mass	mass	ADJ
admet-535	114	17	spectrometers	spectrometer	NOUN
admet-535	114	18	,	,	PUNCT
admet-535	114	19	commonly	commonly	ADV
admet-535	114	20	used	use	VERB
admet-535	114	21	as	as	ADP
admet-535	114	22	detectors	detector	NOUN
admet-535	114	23	in	in	ADP
admet-535	114	24	subsequent	subsequent	ADJ
admet-535	114	25	experiments	experiment	NOUN
admet-535	114	26	involving	involve	VERB
admet-535	114	27	the	the	DET
admet-535	114	28	use	use	NOUN
admet-535	114	29	of	of	ADP
admet-535	114	30	cmac	cmac	NOUN
admet-535	114	31	.	.	PUNCT
admet-535	115	1	the	the	DET
admet-535	115	2	use	use	NOUN
admet-535	115	3	of	of	ADP
admet-535	115	4	tris	tris	ADJ
admet-535	115	5	-	-	PUNCT
admet-535	115	6	hcl	hcl	NOUN
admet-535	115	7	buffer	buffer	NOUN
admet-535	115	8	would	would	AUX
admet-535	115	9	result	result	VERB
admet-535	115	10	in	in	ADP
admet-535	115	11	an	an	DET
admet-535	115	12	additional	additional	ADJ
admet-535	115	13	tris	tris	NOUN
admet-535	115	14	peak	peak	NOUN
admet-535	115	15	(	(	PUNCT
admet-535	115	16	m	m	NOUN
admet-535	115	17	/	/	SYM
admet-535	115	18	z	z	NOUN
admet-535	115	19	122.1	122.1	NUM
admet-535	115	20	,	,	PUNCT
admet-535	115	21	positive	positive	ADJ
admet-535	115	22	ionization	ionization	NOUN
admet-535	115	23	mode	mode	NOUN
admet-535	115	24	)	)	PUNCT
admet-535	115	25	in	in	ADP
admet-535	115	26	the	the	DET
admet-535	115	27	chromatograms	chromatogram	NOUN
admet-535	115	28	.	.	PUNCT
admet-535	116	1	following	follow	VERB
admet-535	116	2	the	the	DET
admet-535	116	3	three	three	NUM
admet-535	116	4	washes	wash	NOUN
admet-535	116	5	,	,	PUNCT
admet-535	116	6	the	the	DET
admet-535	116	7	pellet	pellet	NOUN
admet-535	116	8	is	be	AUX
admet-535	116	9	suspended	suspend	VERB
admet-535	116	10	in	in	ADP
admet-535	116	11	1	1	NUM
admet-535	116	12	ml	ml	NOUN
admet-535	116	13	of	of	ADP
admet-535	116	14	ammonium	ammonium	NOUN
admet-535	116	15	acetate	acetate	NOUN
admet-535	116	16	buffer	buffer	NOUN
admet-535	116	17	and	and	CCONJ
admet-535	116	18	packed	pack	VERB
admet-535	116	19	in	in	ADP
admet-535	116	20	a	a	DET
admet-535	116	21	glass	glass	NOUN
admet-535	116	22	column	column	NOUN
admet-535	116	23	to	to	PART
admet-535	116	24	produce	produce	VERB
admet-535	116	25	a	a	DET
admet-535	116	26	transmembrane	transmembrane	ADJ
admet-535	116	27	protein	protein	NOUN
admet-535	116	28	iam.pc	iam.pc	PROPN
admet-535	116	29	cmac	cmac	NOUN
admet-535	116	30	column	column	NOUN
admet-535	116	31	tmp	tmp	NOUN
admet-535	116	32	-	-	PUNCT
admet-535	116	33	cmac	cmac	NOUN
admet-535	116	34	(	(	PUNCT
admet-535	116	35	figure	figure	NOUN
admet-535	116	36	4	4	NUM
admet-535	116	37	)	)	PUNCT
admet-535	116	38	.	.	PUNCT
admet-535	117	1	the	the	DET
admet-535	117	2	packing	packing	NOUN
admet-535	117	3	procedure	procedure	NOUN
admet-535	117	4	is	be	AUX
admet-535	117	5	a	a	DET
admet-535	117	6	low	low	ADJ
admet-535	117	7	-	-	PUNCT
admet-535	117	8	pressure	pressure	NOUN
admet-535	117	9	packing	packing	NOUN
admet-535	117	10	and	and	CCONJ
admet-535	117	11	therefore	therefore	ADV
admet-535	117	12	does	do	AUX
admet-535	117	13	not	not	PART
admet-535	117	14	require	require	VERB
admet-535	117	15	any	any	DET
admet-535	117	16	sophisticated	sophisticated	ADJ
admet-535	117	17	equipment	equipment	NOUN
admet-535	117	18	.	.	PUNCT
admet-535	118	1	the	the	DET
admet-535	118	2	packing	packing	NOUN
admet-535	118	3	process	process	NOUN
admet-535	118	4	resembles	resemble	VERB
admet-535	118	5	the	the	DET
admet-535	118	6	slurry	slurry	NOUN
admet-535	118	7	pack	pack	NOUN
admet-535	118	8	procedure	procedure	NOUN
admet-535	118	9	used	use	VERB
admet-535	118	10	in	in	ADP
admet-535	118	11	classical	classical	ADJ
admet-535	118	12	column	column	NOUN
admet-535	118	13	preparation	preparation	NOUN
admet-535	118	14	for	for	ADP
admet-535	118	15	the	the	DET
admet-535	118	16	isolation	isolation	NOUN
admet-535	118	17	of	of	ADP
admet-535	118	18	secondary	secondary	ADJ
admet-535	118	19	metabolites	metabolite	NOUN
admet-535	118	20	,	,	PUNCT
admet-535	118	21	but	but	CCONJ
admet-535	118	22	on	on	ADP
admet-535	118	23	a	a	DET
admet-535	118	24	smaller	small	ADJ
admet-535	118	25	scale	scale	NOUN
admet-535	118	26	.	.	PUNCT
admet-535	119	1	after	after	ADP
admet-535	119	2	packing	pack	VERB
admet-535	119	3	the	the	DET
admet-535	119	4	column	column	NOUN
admet-535	119	5	should	should	AUX
admet-535	119	6	be	be	AUX
admet-535	119	7	washed	wash	VERB
admet-535	119	8	with	with	ADP
admet-535	119	9	running	run	VERB
admet-535	119	10	buffer	buffer	NOUN
admet-535	119	11	(	(	PUNCT
admet-535	119	12	ammonium	ammonium	NOUN
admet-535	119	13	acetate	acetate	NOUN
admet-535	119	14	,	,	PUNCT
admet-535	119	15	10	10	NUM
admet-535	119	16	mm	mm	NOUN
admet-535	119	17	,	,	PUNCT
admet-535	119	18	ph	ph	NOUN
admet-535	119	19	7.4	7.4	NUM
admet-535	119	20	)	)	PUNCT
admet-535	119	21	at	at	ADP
admet-535	119	22	the	the	DET
admet-535	119	23	flow	flow	NOUN
admet-535	119	24	rate	rate	NOUN
admet-535	119	25	of	of	ADP
admet-535	119	26	approximately	approximately	ADV
admet-535	119	27	0.2	0.2	NUM
admet-535	119	28	ml	ml	NOUN
admet-535	119	29	/	/	SYM
admet-535	119	30	min	min	PROPN
admet-535	119	31	.	.	PROPN
admet-535	119	32	column	column	NOUN
admet-535	119	33	characterization	characterization	NOUN
admet-535	119	34	and	and	CCONJ
admet-535	119	35	usage	usage	NOUN
admet-535	119	36	after	after	ADP
admet-535	119	37	completing	complete	VERB
admet-535	119	38	all	all	DET
admet-535	119	39	the	the	DET
admet-535	119	40	preparation	preparation	NOUN
admet-535	119	41	steps	step	NOUN
admet-535	119	42	,	,	PUNCT
admet-535	119	43	the	the	DET
admet-535	119	44	moment	moment	NOUN
admet-535	119	45	of	of	ADP
admet-535	119	46	truth	truth	NOUN
admet-535	119	47	comes	come	VERB
admet-535	119	48	:	:	PUNCT
admet-535	119	49	testing	test	VERB
admet-535	119	50	the	the	DET
admet-535	119	51	column	column	NOUN
admet-535	119	52	to	to	PART
admet-535	119	53	check	check	VERB
admet-535	119	54	if	if	SCONJ
admet-535	119	55	functional	functional	ADJ
admet-535	119	56	receptors	receptor	NOUN
admet-535	119	57	are	be	AUX
admet-535	119	58	immobilized	immobilize	VERB
admet-535	119	59	on	on	ADP
admet-535	119	60	the	the	DET
admet-535	119	61	surface	surface	NOUN
admet-535	119	62	of	of	ADP
admet-535	119	63	the	the	DET
admet-535	119	64	iam	iam	PROPN
admet-535	119	65	particles	particle	NOUN
admet-535	119	66	.	.	PUNCT
admet-535	120	1	this	this	PRON
admet-535	120	2	can	can	AUX
admet-535	120	3	be	be	AUX
admet-535	120	4	achieved	achieve	VERB
admet-535	120	5	through	through	ADP
admet-535	120	6	several	several	ADJ
admet-535	120	7	experimental	experimental	ADJ
admet-535	120	8	ways	way	NOUN
admet-535	120	9	.	.	PUNCT
admet-535	121	1	firstly	firstly	ADV
admet-535	121	2	,	,	PUNCT
admet-535	121	3	the	the	DET
admet-535	121	4	immobilization	immobilization	NOUN
admet-535	121	5	of	of	ADP
admet-535	121	6	transmembrane	transmembrane	ADJ
admet-535	121	7	proteins	protein	NOUN
admet-535	121	8	onto	onto	ADP
admet-535	121	9	iam	iam	PROPN
admet-535	121	10	particles	particle	NOUN
admet-535	121	11	can	can	AUX
admet-535	121	12	be	be	AUX
admet-535	121	13	confirmed	confirm	VERB
admet-535	121	14	using	use	VERB
admet-535	121	15	confocal	confocal	ADJ
admet-535	121	16	microscopy	microscopy	NOUN
admet-535	121	17	[	[	X
admet-535	121	18	44	44	NUM
admet-535	121	19	]	]	PUNCT
admet-535	121	20	.	.	PUNCT
admet-535	122	1	iam	iam	PROPN
admet-535	122	2	with	with	ADP
admet-535	122	3	immobilized	immobilized	ADJ
admet-535	122	4	cell	cell	NOUN
admet-535	122	5	membrane	membrane	NOUN
admet-535	122	6	fragments	fragment	NOUN
admet-535	122	7	is	be	AUX
admet-535	122	8	incubated	incubate	VERB
admet-535	122	9	with	with	ADP
admet-535	122	10	a	a	DET
admet-535	122	11	ligand	ligand	NOUN
admet-535	122	12	known	know	VERB
admet-535	122	13	to	to	PART
admet-535	122	14	bind	bind	VERB
admet-535	122	15	to	to	ADP
admet-535	122	16	the	the	DET
admet-535	122	17	target	target	NOUN
admet-535	122	18	protein	protein	NOUN
admet-535	122	19	.	.	PUNCT
admet-535	123	1	the	the	DET
admet-535	123	2	ligand	ligand	NOUN
admet-535	123	3	used	use	VERB
admet-535	123	4	in	in	ADP
admet-535	123	5	the	the	DET
admet-535	123	6	study	study	NOUN
admet-535	123	7	should	should	AUX
admet-535	123	8	contain	contain	VERB
admet-535	123	9	fluorochrome	fluorochrome	NOUN
admet-535	123	10	for	for	ADP
admet-535	123	11	the	the	DET
admet-535	123	12	identification	identification	NOUN
admet-535	123	13	with	with	ADP
admet-535	123	14	the	the	DET
admet-535	123	15	confocal	confocal	ADJ
admet-535	123	16	microscope	microscope	NOUN
admet-535	123	17	.	.	PUNCT
admet-535	124	1	iam	iam	PROPN
admet-535	124	2	particles	particle	NOUN
admet-535	124	3	should	should	AUX
admet-535	124	4	also	also	ADV
admet-535	124	5	be	be	AUX
admet-535	124	6	coincubated	coincubate	VERB
admet-535	124	7	with	with	ADP
admet-535	124	8	a	a	DET
admet-535	124	9	series	series	NOUN
admet-535	124	10	of	of	ADP
admet-535	124	11	concentrations	concentration	NOUN
admet-535	124	12	of	of	ADP
admet-535	124	13	another	another	DET
admet-535	124	14	ligand	ligand	NOUN
admet-535	124	15	,	,	PUNCT
admet-535	124	16	binding	bind	VERB
admet-535	124	17	to	to	ADP
admet-535	124	18	the	the	DET
admet-535	124	19	same	same	ADJ
admet-535	124	20	site	site	NOUN
admet-535	124	21	of	of	ADP
admet-535	124	22	the	the	DET
admet-535	124	23	investigated	investigated	ADJ
admet-535	124	24	receptor	receptor	NOUN
admet-535	124	25	,	,	PUNCT
admet-535	124	26	to	to	PART
admet-535	124	27	confirm	confirm	VERB
admet-535	124	28	the	the	DET
admet-535	124	29	competitive	competitive	ADJ
admet-535	124	30	displacement	displacement	NOUN
admet-535	124	31	of	of	ADP
admet-535	124	32	the	the	DET
admet-535	124	33	ligand	ligand	NOUN
admet-535	124	34	containing	contain	VERB
admet-535	124	35	fluorochrome	fluorochrome	NOUN
admet-535	124	36	.	.	PUNCT
admet-535	125	1	in	in	ADP
admet-535	125	2	another	another	DET
admet-535	125	3	set	set	NOUN
admet-535	125	4	of	of	ADP
admet-535	125	5	experiments	experiment	NOUN
admet-535	125	6	confirming	confirm	VERB
admet-535	125	7	the	the	DET
admet-535	125	8	immobilization	immobilization	NOUN
admet-535	125	9	of	of	ADP
admet-535	125	10	functional	functional	ADJ
admet-535	125	11	receptors	receptor	NOUN
admet-535	125	12	onto	onto	ADP
admet-535	125	13	iam	iam	PROPN
admet-535	125	14	particles	particle	NOUN
admet-535	125	15	an	an	DET
admet-535	125	16	artificial	artificial	ADJ
admet-535	125	17	mixture	mixture	NOUN
admet-535	125	18	of	of	ADP
admet-535	125	19	known	know	VERB
admet-535	125	20	binders	binder	NOUN
admet-535	125	21	and	and	CCONJ
admet-535	125	22	non	non	NOUN
admet-535	125	23	-	-	NOUN
admet-535	125	24	binders	binder	NOUN
admet-535	125	25	is	be	AUX
admet-535	125	26	injected	inject	VERB
admet-535	125	27	onto	onto	ADP
admet-535	125	28	the	the	DET
admet-535	125	29	column	column	NOUN
admet-535	125	30	.	.	PUNCT
admet-535	126	1	known	know	VERB
admet-535	126	2	binders	binder	NOUN
admet-535	126	3	should	should	AUX
admet-535	126	4	be	be	AUX
admet-535	126	5	retained	retain	VERB
admet-535	126	6	on	on	ADP
admet-535	126	7	the	the	DET
admet-535	126	8	column	column	NOUN
admet-535	126	9	with	with	ADP
admet-535	126	10	the	the	DET
admet-535	126	11	immobilized	immobilized	ADJ
admet-535	126	12	receptors	receptor	NOUN
admet-535	126	13	significantly	significantly	ADV
admet-535	126	14	longer	long	ADV
admet-535	126	15	compared	compare	VERB
admet-535	126	16	to	to	ADP
admet-535	126	17	a	a	DET
admet-535	126	18	negative	negative	ADJ
admet-535	126	19	control	control	NOUN
admet-535	126	20	column	column	NOUN
admet-535	126	21	cmac	cmac	NOUN
admet-535	126	22	(	(	PUNCT
admet-535	126	23	-	-	PUNCT
admet-535	126	24	)	)	PUNCT
admet-535	126	25	.	.	PUNCT
admet-535	127	1	the	the	DET
admet-535	127	2	concept	concept	NOUN
admet-535	127	3	of	of	ADP
admet-535	127	4	negative	negative	ADJ
admet-535	127	5	control	control	NOUN
admet-535	127	6	columns	column	NOUN
admet-535	127	7	is	be	AUX
admet-535	127	8	fully	fully	ADV
admet-535	127	9	explained	explain	VERB
admet-535	127	10	in	in	ADP
admet-535	127	11	the	the	DET
admet-535	127	12	next	next	ADJ
admet-535	127	13	section	section	NOUN
admet-535	127	14	of	of	ADP
admet-535	127	15	this	this	DET
admet-535	127	16	article	article	NOUN
admet-535	127	17	discussing	discuss	VERB
admet-535	127	18	the	the	DET
admet-535	127	19	use	use	NOUN
admet-535	127	20	of	of	ADP
admet-535	127	21	cmac	cmac	NOUN
admet-535	127	22	columns	column	NOUN
admet-535	127	23	in	in	ADP
admet-535	127	24	drug	drug	NOUN
admet-535	127	25	discovery	discovery	NOUN
admet-535	127	26	from	from	ADP
admet-535	127	27	natural	natural	ADJ
admet-535	127	28	samples	sample	NOUN
admet-535	127	29	.	.	PUNCT
admet-535	128	1	cayman	cayman	PROPN
admet-535	128	2	,	,	PUNCT
admet-535	128	3	omri	omri	PROPN
admet-535	128	4	&	&	CCONJ
admet-535	128	5	ciesla	ciesla	PROPN
admet-535	128	6	admet	admet	PROPN
admet-535	128	7	&	&	CCONJ
admet-535	128	8	dmpk	dmpk	PROPN
admet-535	128	9	6(3	6(3	PROPN
admet-535	128	10	)	)	PUNCT
admet-535	128	11	(	(	PUNCT
admet-535	128	12	2018	2018	NUM
admet-535	128	13	)	)	PUNCT
admet-535	128	14	200	200	NUM
admet-535	128	15	-	-	SYM
admet-535	128	16	214	214	NUM
admet-535	128	17	206	206	NUM
admet-535	128	18	figure	figure	NOUN
admet-535	128	19	4	4	NUM
admet-535	128	20	.	.	PUNCT
admet-535	128	21	cell	cell	NOUN
admet-535	128	22	membrane	membrane	NOUN
admet-535	128	23	affinity	affinity	NOUN
admet-535	128	24	chromatography	chromatography	NOUN
admet-535	128	25	column	column	NOUN
admet-535	128	26	after	after	ADP
admet-535	128	27	packing	pack	VERB
admet-535	128	28	iam	iam	PROPN
admet-535	128	29	particles	particle	NOUN
admet-535	128	30	with	with	ADP
admet-535	128	31	the	the	DET
admet-535	128	32	immobilized	immobilized	ADJ
admet-535	128	33	cell	cell	NOUN
admet-535	128	34	membrane	membrane	NOUN
admet-535	128	35	fragments	fragment	NOUN
admet-535	128	36	into	into	ADP
admet-535	128	37	a	a	DET
admet-535	128	38	glass	glass	NOUN
admet-535	128	39	column	column	NOUN
admet-535	128	40	finally	finally	ADV
admet-535	128	41	,	,	PUNCT
admet-535	128	42	a	a	DET
admet-535	128	43	series	series	NOUN
admet-535	128	44	of	of	ADP
admet-535	128	45	concentrations	concentration	NOUN
admet-535	128	46	of	of	ADP
admet-535	128	47	a	a	DET
admet-535	128	48	known	know	VERB
admet-535	128	49	high	high	ADJ
admet-535	128	50	-	-	PUNCT
admet-535	128	51	affinity	affinity	NOUN
admet-535	128	52	ligand	ligand	NOUN
admet-535	128	53	should	should	AUX
admet-535	128	54	be	be	AUX
admet-535	128	55	injected	inject	VERB
admet-535	128	56	in	in	ADP
admet-535	128	57	consecutive	consecutive	ADJ
admet-535	128	58	runs	run	NOUN
admet-535	128	59	onto	onto	ADP
admet-535	128	60	the	the	DET
admet-535	128	61	cmac	cmac	NOUN
admet-535	128	62	column	column	NOUN
admet-535	128	63	to	to	PART
admet-535	128	64	determine	determine	VERB
admet-535	128	65	the	the	DET
admet-535	128	66	compound	compound	NOUN
admet-535	128	67	’s	’s	PART
admet-535	128	68	binding	bind	VERB
admet-535	128	69	affinity	affinity	NOUN
admet-535	128	70	(	(	PUNCT
admet-535	128	71	kd	kd	PROPN
admet-535	128	72	)	)	PUNCT
admet-535	129	1	[	[	X
admet-535	129	2	11	11	NUM
admet-535	129	3	]	]	PUNCT
admet-535	129	4	.	.	PUNCT
admet-535	130	1	the	the	DET
admet-535	130	2	binding	bind	VERB
admet-535	130	3	affinity	affinity	NOUN
admet-535	130	4	value	value	NOUN
admet-535	130	5	is	be	AUX
admet-535	130	6	obtained	obtain	VERB
admet-535	130	7	using	use	VERB
admet-535	130	8	frontal	frontal	ADJ
admet-535	130	9	affinity	affinity	NOUN
admet-535	130	10	chromatography	chromatography	NOUN
admet-535	130	11	(	(	PUNCT
admet-535	130	12	fac	fac	PROPN
admet-535	130	13	)	)	PUNCT
admet-535	130	14	and	and	CCONJ
admet-535	130	15	a	a	DET
admet-535	130	16	detector	detector	NOUN
admet-535	130	17	sensitive	sensitive	ADJ
admet-535	130	18	enough	enough	ADV
admet-535	130	19	to	to	PART
admet-535	130	20	detect	detect	VERB
admet-535	130	21	the	the	DET
admet-535	130	22	marker	marker	NOUN
admet-535	130	23	ligand	ligand	NOUN
admet-535	130	24	at	at	ADP
admet-535	130	25	the	the	DET
admet-535	130	26	used	use	VERB
admet-535	130	27	concentration	concentration	NOUN
admet-535	130	28	.	.	PUNCT
admet-535	131	1	mass	mass	ADJ
admet-535	131	2	spectrometers	spectrometer	NOUN
admet-535	131	3	are	be	AUX
admet-535	131	4	most	most	ADV
admet-535	131	5	commonly	commonly	ADV
admet-535	131	6	used	use	VERB
admet-535	131	7	in	in	ADP
admet-535	131	8	this	this	DET
admet-535	131	9	approach	approach	NOUN
admet-535	131	10	,	,	PUNCT
admet-535	131	11	but	but	CCONJ
admet-535	131	12	any	any	DET
admet-535	131	13	other	other	ADJ
admet-535	131	14	detector	detector	NOUN
admet-535	131	15	suitable	suitable	ADJ
admet-535	131	16	for	for	ADP
admet-535	131	17	the	the	DET
admet-535	131	18	detection	detection	NOUN
admet-535	131	19	of	of	ADP
admet-535	131	20	the	the	DET
admet-535	131	21	marker	marker	NOUN
admet-535	131	22	ligand	ligand	NOUN
admet-535	131	23	may	may	AUX
admet-535	131	24	be	be	AUX
admet-535	131	25	applied	apply	VERB
admet-535	131	26	.	.	PUNCT
admet-535	132	1	the	the	DET
admet-535	132	2	concept	concept	NOUN
admet-535	132	3	of	of	ADP
admet-535	132	4	frontal	frontal	ADJ
admet-535	132	5	affinity	affinity	NOUN
admet-535	132	6	chromatography	chromatography	NOUN
admet-535	132	7	was	be	AUX
admet-535	132	8	thoroughly	thoroughly	ADV
admet-535	132	9	reviewed	review	VERB
admet-535	132	10	in	in	ADP
admet-535	132	11	the	the	DET
admet-535	132	12	paper	paper	NOUN
admet-535	132	13	by	by	ADP
admet-535	132	14	ng	ng	PROPN
admet-535	132	15	et	et	PROPN
admet-535	132	16	al	al	PROPN
admet-535	132	17	.	.	PUNCT
admet-535	133	1	[	[	X
admet-535	133	2	45	45	NUM
admet-535	133	3	]	]	PUNCT
admet-535	133	4	and	and	CCONJ
admet-535	133	5	will	will	AUX
admet-535	133	6	only	only	ADV
admet-535	133	7	be	be	AUX
admet-535	133	8	shortly	shortly	ADV
admet-535	133	9	discussed	discuss	VERB
admet-535	133	10	in	in	ADP
admet-535	133	11	this	this	DET
admet-535	133	12	review	review	NOUN
admet-535	133	13	.	.	PUNCT
admet-535	134	1	frontal	frontal	ADJ
admet-535	134	2	affinity	affinity	NOUN
admet-535	134	3	chromatography	chromatography	NOUN
admet-535	134	4	is	be	AUX
admet-535	134	5	a	a	DET
admet-535	134	6	biophysical	biophysical	ADJ
admet-535	134	7	method	method	NOUN
admet-535	134	8	to	to	PART
admet-535	134	9	study	study	VERB
admet-535	134	10	the	the	DET
admet-535	134	11	interactions	interaction	NOUN
admet-535	134	12	between	between	ADP
admet-535	134	13	a	a	DET
admet-535	134	14	ligand	ligand	ADJ
admet-535	134	15	present	present	NOUN
admet-535	134	16	in	in	ADP
admet-535	134	17	the	the	DET
admet-535	134	18	mobile	mobile	ADJ
admet-535	134	19	phase	phase	NOUN
admet-535	134	20	and	and	CCONJ
admet-535	134	21	the	the	DET
admet-535	134	22	immobilized	immobilized	ADJ
admet-535	134	23	target	target	NOUN
admet-535	134	24	molecule	molecule	NOUN
admet-535	134	25	,	,	PUNCT
admet-535	134	26	e.g.	e.g.	ADV
admet-535	134	27	a	a	DET
admet-535	134	28	receptor	receptor	NOUN
admet-535	134	29	[	[	X
admet-535	134	30	45	45	NUM
admet-535	134	31	]	]	PUNCT
admet-535	134	32	.	.	PUNCT
admet-535	135	1	a	a	DET
admet-535	135	2	known	know	VERB
admet-535	135	3	marker	marker	NOUN
admet-535	135	4	ligand	ligand	NOUN
admet-535	135	5	(	(	PUNCT
admet-535	135	6	for	for	ADP
admet-535	135	7	example	example	NOUN
admet-535	135	8	epibatidine	epibatidine	VERB
admet-535	135	9	for	for	ADP
admet-535	135	10	nachrs	nachrs	ADV
admet-535	135	11	)	)	PUNCT
admet-535	135	12	at	at	ADP
admet-535	135	13	constant	constant	ADJ
admet-535	135	14	concentration	concentration	NOUN
admet-535	135	15	is	be	AUX
admet-535	135	16	run	run	VERB
admet-535	135	17	through	through	ADP
admet-535	135	18	the	the	DET
admet-535	135	19	column	column	NOUN
admet-535	135	20	with	with	ADP
admet-535	135	21	the	the	DET
admet-535	135	22	immobilized	immobilized	ADJ
admet-535	135	23	transmembrane	transmembrane	NOUN
admet-535	135	24	protein	protein	NOUN
admet-535	135	25	,	,	PUNCT
admet-535	135	26	producing	produce	VERB
admet-535	135	27	a	a	DET
admet-535	135	28	characteristic	characteristic	ADJ
admet-535	135	29	sigmoidal	sigmoidal	NOUN
admet-535	135	30	breakthrough	breakthrough	NOUN
admet-535	135	31	curve	curve	NOUN
admet-535	135	32	(	(	PUNCT
admet-535	135	33	figure	figure	NOUN
admet-535	135	34	5	5	NUM
admet-535	135	35	)	)	PUNCT
admet-535	135	36	.	.	PUNCT
admet-535	136	1	at	at	ADP
admet-535	136	2	the	the	DET
admet-535	136	3	beginning	beginning	NOUN
admet-535	136	4	of	of	ADP
admet-535	136	5	the	the	DET
admet-535	136	6	analysis	analysis	NOUN
admet-535	136	7	,	,	PUNCT
admet-535	136	8	the	the	DET
admet-535	136	9	number	number	NOUN
admet-535	136	10	of	of	ADP
admet-535	136	11	available	available	ADJ
admet-535	136	12	binding	bind	VERB
admet-535	136	13	sites	site	NOUN
admet-535	136	14	(	(	PUNCT
admet-535	136	15	immobilized	immobilized	ADJ
admet-535	136	16	transmembrane	transmembrane	ADJ
admet-535	136	17	protein	protein	NOUN
admet-535	136	18	)	)	PUNCT
admet-535	136	19	is	be	AUX
admet-535	136	20	higher	high	ADJ
admet-535	136	21	than	than	ADP
admet-535	136	22	the	the	DET
admet-535	136	23	number	number	NOUN
admet-535	136	24	of	of	ADP
admet-535	136	25	the	the	DET
admet-535	136	26	titrating	titrate	VERB
admet-535	136	27	molecules	molecule	NOUN
admet-535	136	28	of	of	ADP
admet-535	136	29	the	the	DET
admet-535	136	30	marker	marker	NOUN
admet-535	136	31	ligand	ligand	NOUN
admet-535	136	32	(	(	PUNCT
admet-535	136	33	the	the	DET
admet-535	136	34	flat	flat	ADJ
admet-535	136	35	bottom	bottom	ADJ
admet-535	136	36	portion	portion	NOUN
admet-535	136	37	of	of	ADP
admet-535	136	38	the	the	DET
admet-535	136	39	curve	curve	NOUN
admet-535	136	40	)	)	PUNCT
admet-535	136	41	.	.	PUNCT
admet-535	137	1	after	after	SCONJ
admet-535	137	2	all	all	DET
admet-535	137	3	the	the	DET
admet-535	137	4	binding	bind	VERB
admet-535	137	5	sites	site	NOUN
admet-535	137	6	are	be	AUX
admet-535	137	7	saturated	saturate	VERB
admet-535	137	8	with	with	ADP
admet-535	137	9	the	the	DET
admet-535	137	10	ligand	ligand	NOUN
admet-535	137	11	,	,	PUNCT
admet-535	137	12	the	the	DET
admet-535	137	13	concentration	concentration	NOUN
admet-535	137	14	of	of	ADP
admet-535	137	15	the	the	DET
admet-535	137	16	ligand	ligand	NOUN
admet-535	137	17	leaving	leave	VERB
admet-535	137	18	the	the	DET
admet-535	137	19	column	column	NOUN
admet-535	137	20	gradually	gradually	ADV
admet-535	137	21	increases	increase	VERB
admet-535	137	22	producing	produce	VERB
admet-535	137	23	the	the	DET
admet-535	137	24	breakthrough	breakthrough	NOUN
admet-535	137	25	.	.	PUNCT
admet-535	138	1	at	at	ADP
admet-535	138	2	the	the	DET
admet-535	138	3	end	end	NOUN
admet-535	138	4	of	of	ADP
admet-535	138	5	the	the	DET
admet-535	138	6	analysis	analysis	NOUN
admet-535	138	7	,	,	PUNCT
admet-535	138	8	the	the	DET
admet-535	138	9	concentration	concentration	NOUN
admet-535	138	10	of	of	ADP
admet-535	138	11	the	the	DET
admet-535	138	12	ligand	ligand	NOUN
admet-535	138	13	entering	entering	NOUN
admet-535	138	14	and	and	CCONJ
admet-535	138	15	eluting	eluting	NOUN
admet-535	138	16	from	from	ADP
admet-535	138	17	the	the	DET
admet-535	138	18	column	column	NOUN
admet-535	138	19	is	be	AUX
admet-535	138	20	identical	identical	ADJ
admet-535	138	21	as	as	SCONJ
admet-535	138	22	illustrated	illustrate	VERB
admet-535	138	23	by	by	ADP
admet-535	138	24	the	the	DET
admet-535	138	25	plateau	plateau	NOUN
admet-535	138	26	portion	portion	NOUN
admet-535	138	27	of	of	ADP
admet-535	138	28	the	the	DET
admet-535	138	29	curve	curve	NOUN
admet-535	138	30	.	.	PUNCT
admet-535	139	1	the	the	DET
admet-535	139	2	inflexion	inflexion	NOUN
admet-535	139	3	point	point	NOUN
admet-535	139	4	depends	depend	VERB
admet-535	139	5	on	on	ADP
admet-535	139	6	the	the	DET
admet-535	139	7	ligand	ligand	ADJ
admet-535	139	8	concentration	concentration	NOUN
admet-535	139	9	,	,	PUNCT
admet-535	139	10	the	the	DET
admet-535	139	11	number	number	NOUN
admet-535	139	12	of	of	ADP
admet-535	139	13	available	available	ADJ
admet-535	139	14	binding	bind	VERB
admet-535	139	15	sites	site	NOUN
admet-535	139	16	and	and	CCONJ
admet-535	139	17	the	the	DET
admet-535	139	18	compound	compound	NOUN
admet-535	139	19	’s	’s	PART
admet-535	139	20	binding	bind	VERB
admet-535	139	21	affinity	affinity	NOUN
admet-535	139	22	[	[	X
admet-535	139	23	45	45	NUM
admet-535	139	24	]	]	PUNCT
admet-535	139	25	.	.	PUNCT
admet-535	140	1	typical	typical	ADJ
admet-535	140	2	chromatograms	chromatogram	NOUN
admet-535	140	3	using	use	VERB
admet-535	140	4	fac	fac	PROPN
admet-535	140	5	obtained	obtain	VERB
admet-535	140	6	for	for	ADP
admet-535	140	7	orthosteric	orthosteric	ADJ
admet-535	140	8	(	(	PUNCT
admet-535	140	9	a	a	NOUN
admet-535	140	10	)	)	PUNCT
admet-535	140	11	and	and	CCONJ
admet-535	140	12	allosteric	allosteric	ADJ
admet-535	140	13	(	(	PUNCT
admet-535	140	14	b	b	NOUN
admet-535	140	15	)	)	PUNCT
admet-535	140	16	nachr	nachr	NOUN
admet-535	140	17	binding	bind	VERB
admet-535	140	18	sites	site	NOUN
admet-535	140	19	are	be	AUX
admet-535	140	20	presented	present	VERB
admet-535	140	21	in	in	ADP
admet-535	140	22	figure	figure	NOUN
admet-535	140	23	5	5	NUM
admet-535	141	1	[	[	X
admet-535	141	2	30	30	NUM
admet-535	141	3	]	]	PUNCT
admet-535	141	4	.	.	PUNCT
admet-535	142	1	using	use	VERB
admet-535	142	2	frontal	frontal	ADJ
admet-535	142	3	affinity	affinity	NOUN
admet-535	142	4	chromatography	chromatography	NOUN
admet-535	142	5	with	with	ADP
admet-535	142	6	cmac	cmac	NOUN
admet-535	142	7	columns	column	NOUN
admet-535	142	8	was	be	AUX
admet-535	142	9	proved	prove	VERB
admet-535	142	10	not	not	PART
admet-535	142	11	only	only	ADV
admet-535	142	12	to	to	PART
admet-535	142	13	be	be	AUX
admet-535	142	14	useful	useful	ADJ
admet-535	142	15	in	in	ADP
admet-535	142	16	characterization	characterization	NOUN
admet-535	142	17	and	and	CCONJ
admet-535	142	18	studies	study	NOUN
admet-535	142	19	involving	involve	VERB
admet-535	142	20	the	the	DET
admet-535	142	21	orthosteric	orthosteric	ADJ
admet-535	142	22	but	but	CCONJ
admet-535	142	23	also	also	ADV
admet-535	142	24	with	with	ADP
admet-535	142	25	the	the	DET
admet-535	142	26	allosteric	allosteric	ADJ
admet-535	142	27	binding	bind	VERB
admet-535	142	28	sites	site	NOUN
admet-535	142	29	of	of	ADP
admet-535	142	30	the	the	DET
admet-535	142	31	immobilized	immobilized	ADJ
admet-535	142	32	transmembrane	transmembrane	ADJ
admet-535	142	33	protein	protein	NOUN
admet-535	142	34	[	[	X
admet-535	142	35	30	30	NUM
admet-535	142	36	]	]	PUNCT
admet-535	142	37	.	.	PUNCT
admet-535	143	1	frontal	frontal	ADJ
admet-535	143	2	displacement	displacement	ADJ
admet-535	143	3	chromatography	chromatography	NOUN
admet-535	143	4	can	can	AUX
admet-535	143	5	be	be	AUX
admet-535	143	6	applied	apply	VERB
admet-535	143	7	to	to	PART
admet-535	143	8	determine	determine	VERB
admet-535	143	9	the	the	DET
admet-535	143	10	binding	bind	VERB
admet-535	143	11	affinity	affinity	NOUN
admet-535	143	12	of	of	ADP
admet-535	143	13	unknown	unknown	ADJ
admet-535	143	14	ligand	ligand	NOUN
admet-535	143	15	binding	bind	VERB
admet-535	143	16	to	to	ADP
admet-535	143	17	the	the	DET
admet-535	143	18	same	same	ADJ
admet-535	143	19	site	site	NOUN
admet-535	143	20	as	as	ADP
admet-535	143	21	the	the	DET
admet-535	143	22	marker	marker	NOUN
admet-535	143	23	ligand	ligand	NOUN
admet-535	143	24	.	.	PUNCT
admet-535	144	1	it	it	PRON
admet-535	144	2	is	be	AUX
admet-535	144	3	done	do	VERB
admet-535	144	4	by	by	ADP
admet-535	144	5	injecting	inject	VERB
admet-535	144	6	constant	constant	ADJ
admet-535	144	7	concentration	concentration	NOUN
admet-535	144	8	of	of	ADP
admet-535	144	9	the	the	DET
admet-535	144	10	marker	marker	NOUN
admet-535	144	11	ligand	ligand	NOUN
admet-535	144	12	with	with	ADP
admet-535	144	13	varying	vary	VERB
admet-535	144	14	concentrations	concentration	NOUN
admet-535	144	15	of	of	ADP
admet-535	144	16	the	the	DET
admet-535	144	17	studied	studied	ADJ
admet-535	144	18	displacer	displacer	NOUN
admet-535	144	19	and	and	CCONJ
admet-535	144	20	using	use	VERB
admet-535	144	21	the	the	DET
admet-535	144	22	following	follow	VERB
admet-535	144	23	equation	equation	NOUN
admet-535	144	24	[	[	X
admet-535	144	25	11	11	NUM
admet-535	144	26	]	]	SYM
admet-535	144	27	:	:	PUNCT
admet-535	144	28	-1	-1	INTJ
admet-535	145	1	where	where	SCONJ
admet-535	145	2	:	:	PUNCT
admet-535	145	3	[	[	X
admet-535	145	4	dis	dis	X
admet-535	145	5	]	]	X
admet-535	145	6	–	–	PUNCT
admet-535	145	7	concentration	concentration	NOUN
admet-535	145	8	of	of	ADP
admet-535	145	9	the	the	DET
admet-535	145	10	displacer	displacer	NOUN
admet-535	145	11	;	;	PUNCT
admet-535	145	12	v	v	X
admet-535	145	13	–	–	PUNCT
admet-535	145	14	retention	retention	NOUN
admet-535	145	15	volume	volume	NOUN
admet-535	145	16	of	of	ADP
admet-535	145	17	the	the	DET
admet-535	145	18	marker	marker	NOUN
admet-535	145	19	ligand	ligand	NOUN
admet-535	145	20	,	,	PUNCT
admet-535	145	21	when	when	SCONJ
admet-535	145	22	its	its	PRON
admet-535	145	23	specific	specific	ADJ
admet-535	145	24	concentration	concentration	NOUN
admet-535	145	25	is	be	AUX
admet-535	145	26	completely	completely	ADV
admet-535	145	27	suppressed	suppress	VERB
admet-535	145	28	,	,	PUNCT
admet-535	145	29	e.g.	e.g.	ADV
admet-535	145	30	by	by	ADP
admet-535	145	31	a	a	DET
admet-535	145	32	high	high	ADJ
admet-535	145	33	concentration	concentration	NOUN
admet-535	145	34	of	of	ADP
admet-535	145	35	the	the	DET
admet-535	145	36	displacer	displacer	NOUN
admet-535	145	37	;	;	PUNCT
admet-535	145	38	kddis	kddis	X
admet-535	145	39	–	–	PUNCT
admet-535	145	40	dissociation	dissociation	NOUN
admet-535	145	41	constant	constant	ADJ
admet-535	145	42	of	of	ADP
admet-535	145	43	the	the	DET
admet-535	145	44	displacer	displacer	NOUN
admet-535	145	45	;	;	PUNCT
admet-535	145	46	p	p	X
admet-535	145	47	–	–	PUNCT
admet-535	145	48	product	product	NOUN
admet-535	145	49	of	of	ADP
admet-535	145	50	the	the	DET
admet-535	145	51	bmax	bmax	NOUN
admet-535	145	52	(	(	PUNCT
admet-535	145	53	the	the	DET
admet-535	145	54	number	number	NOUN
admet-535	145	55	of	of	ADP
admet-535	145	56	the	the	DET
admet-535	145	57	available	available	ADJ
admet-535	145	58	binding	bind	VERB
admet-535	145	59	sites	site	NOUN
admet-535	145	60	)	)	PUNCT
admet-535	145	61	and	and	CCONJ
admet-535	145	62	(	(	PUNCT
admet-535	145	63	kddis	kddis	PROPN
admet-535	145	64	/	/	SYM
admet-535	145	65	kdmarker	kdmarker	NOUN
admet-535	145	66	)	)	PUNCT
admet-535	145	67	,	,	PUNCT
admet-535	145	68	kdmarker	kdmarker	NOUN
admet-535	145	69	–	–	PUNCT
admet-535	145	70	dissociation	dissociation	NOUN
admet-535	145	71	constant	constant	ADJ
admet-535	145	72	of	of	ADP
admet-535	145	73	the	the	DET
admet-535	145	74	marker	marker	NOUN
admet-535	145	75	ligand	ligand	NOUN
admet-535	146	1	[	[	X
admet-535	146	2	11	11	NUM
admet-535	146	3	]	]	PUNCT
admet-535	146	4	.	.	PUNCT
admet-535	147	1	admet	admet	PROPN
admet-535	147	2	&	&	CCONJ
admet-535	147	3	dmpk	dmpk	PROPN
admet-535	147	4	6(3	6(3	PROPN
admet-535	147	5	)	)	PUNCT
admet-535	147	6	(	(	PUNCT
admet-535	147	7	2018	2018	NUM
admet-535	147	8	)	)	PUNCT
admet-535	147	9	200	200	NUM
admet-535	147	10	-	-	SYM
admet-535	147	11	214	214	NUM
admet-535	147	12	cell	cell	NOUN
admet-535	147	13	membrane	membrane	NOUN
admet-535	147	14	affinity	affinity	NOUN
admet-535	147	15	chromatography	chromatography	NOUN
admet-535	147	16	in	in	ADP
admet-535	147	17	drug	drug	NOUN
admet-535	147	18	discovery	discovery	NOUN
admet-535	147	19	doi	doi	PROPN
admet-535	147	20	:	:	PUNCT
admet-535	147	21	10.5599	10.5599	NUM
admet-535	147	22	/	/	SYM
admet-535	147	23	admet.535	admet.535	PROPN
admet-535	147	24	207	207	NUM
admet-535	147	25	figure	figure	NOUN
admet-535	147	26	5	5	NUM
admet-535	147	27	.	.	PUNCT
admet-535	147	28	frontal	frontal	ADJ
admet-535	147	29	chromatograms	chromatogram	NOUN
admet-535	147	30	of	of	ADP
admet-535	147	31	(	(	PUNCT
admet-535	147	32	a	a	X
admet-535	147	33	)	)	PUNCT
admet-535	147	34	increasing	increase	VERB
admet-535	147	35	concentrations	concentration	NOUN
admet-535	147	36	of	of	ADP
admet-535	147	37	[	[	PUNCT
admet-535	147	38	3	3	NUM
admet-535	147	39	h]-epibatidine	h]-epibatidine	NOUN
admet-535	147	40	(	(	PUNCT
admet-535	147	41	a	a	DET
admet-535	147	42	=	=	NUM
admet-535	147	43	240	240	NUM
admet-535	147	44	pm	pm	NOUN
admet-535	147	45	,	,	PUNCT
admet-535	147	46	b=150	b=150	NOUN
admet-535	147	47	pm	pm	NOUN
admet-535	147	48	,	,	PUNCT
admet-535	147	49	c=100	c=100	PROPN
admet-535	147	50	pm	pm	NOUN
admet-535	147	51	,	,	PUNCT
admet-535	147	52	d=80	d=80	ADJ
admet-535	147	53	pm	pm	NOUN
admet-535	147	54	and	and	CCONJ
admet-535	147	55	e=60	e=60	ADV
admet-535	147	56	pm	pm	PROPN
admet-535	147	57	)	)	PUNCT
admet-535	147	58	on	on	ADP
admet-535	147	59	the	the	DET
admet-535	147	60	α3β4α5	α3β4α5	ADJ
admet-535	147	61	nicotinic	nicotinic	ADJ
admet-535	147	62	receptor	receptor	NOUN
admet-535	147	63	column	column	NOUN
admet-535	147	64	and	and	CCONJ
admet-535	147	65	(	(	PUNCT
admet-535	147	66	b	b	NOUN
admet-535	147	67	)	)	PUNCT
admet-535	147	68	increasing	increase	VERB
admet-535	147	69	concentrations	concentration	NOUN
admet-535	147	70	of	of	ADP
admet-535	147	71	mecamylamine	mecamylamine	NOUN
admet-535	147	72	on	on	ADP
admet-535	147	73	α3β4	α3β4	NUM
admet-535	147	74	nicotinic	nicotinic	ADJ
admet-535	147	75	receptor	receptor	NOUN
admet-535	147	76	column	column	NOUN
admet-535	147	77	.	.	PUNCT
admet-535	148	1	for	for	SCONJ
admet-535	148	2	details	detail	NOUN
admet-535	148	3	please	please	INTJ
admet-535	148	4	refer	refer	VERB
admet-535	148	5	to	to	ADP
admet-535	148	6	the	the	DET
admet-535	148	7	paper	paper	NOUN
admet-535	148	8	by	by	ADP
admet-535	148	9	ciesla	ciesla	PROPN
admet-535	148	10	et	et	PROPN
admet-535	148	11	al	al	PROPN
admet-535	148	12	.	.	PUNCT
admet-535	149	1	[	[	X
admet-535	149	2	30	30	NUM
admet-535	149	3	]	]	PUNCT
admet-535	149	4	.	.	PUNCT
admet-535	150	1	with	with	ADP
admet-535	150	2	permission	permission	NOUN
admet-535	150	3	from	from	ADP
admet-535	150	4	[	[	X
admet-535	150	5	30	30	NUM
admet-535	150	6	]	]	PUNCT
admet-535	150	7	this	this	DET
admet-535	150	8	approach	approach	NOUN
admet-535	150	9	was	be	AUX
admet-535	150	10	for	for	ADP
admet-535	150	11	example	example	NOUN
admet-535	150	12	used	use	VERB
admet-535	150	13	to	to	PART
admet-535	150	14	determine	determine	VERB
admet-535	150	15	kd	kd	PROPN
admet-535	150	16	values	value	NOUN
admet-535	150	17	of	of	ADP
admet-535	150	18	several	several	ADJ
admet-535	150	19	alkaloids	alkaloid	NOUN
admet-535	150	20	binding	bind	VERB
admet-535	150	21	to	to	ADP
admet-535	150	22	34	34	NUM
admet-535	150	23	and	and	CCONJ
admet-535	150	24	345	345	DET
admet-535	150	25	nicotinic	nicotinic	ADJ
admet-535	150	26	receptors	receptor	NOUN
admet-535	150	27	[	[	X
admet-535	150	28	30	30	NUM
admet-535	150	29	]	]	PUNCT
admet-535	150	30	.	.	PUNCT
admet-535	151	1	another	another	DET
admet-535	151	2	chromatographic	chromatographic	ADJ
admet-535	151	3	mode	mode	NOUN
admet-535	151	4	that	that	PRON
admet-535	151	5	can	can	AUX
admet-535	151	6	be	be	AUX
admet-535	151	7	used	use	VERB
admet-535	151	8	to	to	PART
admet-535	151	9	study	study	VERB
admet-535	151	10	interactions	interaction	NOUN
admet-535	151	11	between	between	ADP
admet-535	151	12	the	the	DET
admet-535	151	13	adsorbed	adsorb	VERB
admet-535	151	14	transmembrane	transmembrane	NOUN
admet-535	151	15	receptors	receptor	NOUN
admet-535	151	16	and	and	CCONJ
admet-535	151	17	ligands	ligand	NOUN
admet-535	151	18	is	be	AUX
admet-535	151	19	nonlinear	nonlinear	ADJ
admet-535	151	20	chromatography	chromatography	NOUN
admet-535	151	21	[	[	X
admet-535	151	22	11	11	NUM
admet-535	151	23	]	]	PUNCT
admet-535	151	24	.	.	PUNCT
admet-535	152	1	in	in	ADP
admet-535	152	2	this	this	DET
admet-535	152	3	approach	approach	NOUN
admet-535	152	4	,	,	PUNCT
admet-535	152	5	the	the	DET
admet-535	152	6	investigated	investigate	VERB
admet-535	152	7	small	small	ADJ
admet-535	152	8	molecular	molecular	ADJ
admet-535	152	9	compounds	compound	NOUN
admet-535	152	10	are	be	AUX
admet-535	152	11	injected	inject	VERB
admet-535	152	12	onto	onto	ADP
admet-535	152	13	a	a	DET
admet-535	152	14	cmac	cmac	NOUN
admet-535	152	15	column	column	NOUN
admet-535	152	16	close	close	ADJ
admet-535	152	17	to	to	ADP
admet-535	152	18	,	,	PUNCT
admet-535	152	19	or	or	CCONJ
admet-535	152	20	at	at	ADP
admet-535	152	21	target	target	NOUN
admet-535	152	22	saturation	saturation	NOUN
admet-535	152	23	.	.	PUNCT
admet-535	153	1	the	the	DET
admet-535	153	2	observed	observe	VERB
admet-535	153	3	peak	peak	NOUN
admet-535	153	4	asymmetry	asymmetry	NOUN
admet-535	153	5	allows	allow	VERB
admet-535	153	6	the	the	DET
admet-535	153	7	study	study	NOUN
admet-535	153	8	of	of	ADP
admet-535	153	9	the	the	DET
admet-535	153	10	kinetics	kinetic	NOUN
admet-535	153	11	and	and	CCONJ
admet-535	153	12	thermodynamics	thermodynamic	NOUN
admet-535	153	13	of	of	ADP
admet-535	153	14	interaction	interaction	NOUN
admet-535	153	15	between	between	ADP
admet-535	153	16	the	the	DET
admet-535	153	17	ligands	ligand	NOUN
admet-535	153	18	and	and	CCONJ
admet-535	153	19	immobilized	immobilized	ADJ
admet-535	153	20	protein	protein	NOUN
admet-535	153	21	target	target	NOUN
admet-535	153	22	.	.	PUNCT
admet-535	154	1	cmac	cmac	NOUN
admet-535	154	2	columns	column	NOUN
admet-535	154	3	can	can	AUX
admet-535	154	4	be	be	AUX
admet-535	154	5	used	use	VERB
admet-535	154	6	as	as	ADP
admet-535	154	7	a	a	DET
admet-535	154	8	first	first	ADJ
admet-535	154	9	step	step	NOUN
admet-535	154	10	to	to	PART
admet-535	154	11	identify	identify	VERB
admet-535	154	12	cayman	cayman	PROPN
admet-535	154	13	,	,	PUNCT
admet-535	154	14	omri	omri	PROPN
admet-535	154	15	&	&	CCONJ
admet-535	154	16	ciesla	ciesla	PROPN
admet-535	154	17	admet	admet	PROPN
admet-535	154	18	&	&	CCONJ
admet-535	154	19	dmpk	dmpk	PROPN
admet-535	154	20	6(3	6(3	PROPN
admet-535	154	21	)	)	PUNCT
admet-535	154	22	(	(	PUNCT
admet-535	154	23	2018	2018	NUM
admet-535	154	24	)	)	PUNCT
admet-535	154	25	200	200	NUM
admet-535	154	26	-	-	SYM
admet-535	154	27	214	214	NUM
admet-535	154	28	208	208	NUM
admet-535	154	29	pharmacologically	pharmacologically	ADV
admet-535	154	30	active	active	ADJ
admet-535	154	31	secondary	secondary	ADJ
admet-535	154	32	metabolites	metabolite	NOUN
admet-535	154	33	from	from	ADP
admet-535	154	34	natural	natural	ADJ
admet-535	154	35	mixtures	mixture	NOUN
admet-535	154	36	and	and	CCONJ
admet-535	154	37	after	after	ADP
admet-535	154	38	isolation	isolation	NOUN
admet-535	154	39	of	of	ADP
admet-535	154	40	these	these	DET
admet-535	154	41	compounds	compound	NOUN
admet-535	154	42	,	,	PUNCT
admet-535	154	43	they	they	PRON
admet-535	154	44	can	can	AUX
admet-535	154	45	be	be	AUX
admet-535	154	46	applied	apply	VERB
admet-535	154	47	to	to	PART
admet-535	154	48	obtain	obtain	VERB
admet-535	154	49	pharmacokinetic	pharmacokinetic	ADJ
admet-535	154	50	and	and	CCONJ
admet-535	154	51	pharmacodynamic	pharmacodynamic	ADJ
admet-535	154	52	data	datum	NOUN
admet-535	154	53	.	.	PUNCT
admet-535	155	1	in	in	ADP
admet-535	155	2	zonal	zonal	ADJ
admet-535	155	3	chromatography	chromatography	NOUN
admet-535	155	4	,	,	PUNCT
admet-535	155	5	a	a	DET
admet-535	155	6	small	small	ADJ
admet-535	155	7	amount	amount	NOUN
admet-535	155	8	of	of	ADP
admet-535	155	9	the	the	DET
admet-535	155	10	ligand	ligand	NOUN
admet-535	155	11	is	be	AUX
admet-535	155	12	loaded	load	VERB
admet-535	155	13	onto	onto	ADP
admet-535	155	14	the	the	DET
admet-535	155	15	column	column	NOUN
admet-535	155	16	and	and	CCONJ
admet-535	155	17	this	this	PRON
admet-535	155	18	allows	allow	VERB
admet-535	155	19	for	for	ADP
admet-535	155	20	ranking	rank	VERB
admet-535	155	21	the	the	DET
admet-535	155	22	affinity	affinity	NOUN
admet-535	155	23	of	of	ADP
admet-535	155	24	the	the	DET
admet-535	155	25	investigated	investigate	VERB
admet-535	155	26	compounds	compound	NOUN
admet-535	155	27	[	[	X
admet-535	155	28	11	11	NUM
admet-535	155	29	]	]	PUNCT
admet-535	155	30	.	.	PUNCT
admet-535	156	1	the	the	DET
admet-535	156	2	use	use	NOUN
admet-535	156	3	of	of	ADP
admet-535	156	4	cmacs	cmac	NOUN
admet-535	156	5	in	in	ADP
admet-535	156	6	identification	identification	NOUN
admet-535	156	7	of	of	ADP
admet-535	156	8	pharmacologically	pharmacologically	ADV
admet-535	156	9	active	active	ADJ
admet-535	156	10	metabolites	metabolite	NOUN
admet-535	156	11	from	from	ADP
admet-535	156	12	natural	natural	ADJ
admet-535	156	13	mixtures	mixture	NOUN
admet-535	156	14	in	in	ADP
admet-535	156	15	the	the	DET
admet-535	156	16	early	early	ADJ
admet-535	156	17	reports	report	NOUN
admet-535	156	18	of	of	ADP
admet-535	156	19	cmac	cmac	NOUN
admet-535	156	20	column	column	NOUN
admet-535	156	21	usage	usage	NOUN
admet-535	156	22	,	,	PUNCT
admet-535	156	23	the	the	DET
admet-535	156	24	columns	column	NOUN
admet-535	156	25	were	be	AUX
admet-535	156	26	applied	apply	VERB
admet-535	156	27	to	to	ADP
admet-535	156	28	the	the	DET
admet-535	156	29	study	study	NOUN
admet-535	156	30	of	of	ADP
admet-535	156	31	the	the	DET
admet-535	156	32	binding	bind	VERB
admet-535	156	33	characteristics	characteristic	NOUN
admet-535	156	34	of	of	ADP
admet-535	156	35	the	the	DET
admet-535	156	36	immobilized	immobilized	ADJ
admet-535	156	37	transmembrane	transmembrane	ADJ
admet-535	156	38	proteins	protein	NOUN
admet-535	156	39	[	[	X
admet-535	156	40	7	7	NUM
admet-535	156	41	]	]	PUNCT
admet-535	156	42	.	.	PUNCT
admet-535	157	1	however	however	ADV
admet-535	157	2	,	,	PUNCT
admet-535	157	3	cmac	cmac	NOUN
admet-535	157	4	columns	column	NOUN
admet-535	157	5	can	can	AUX
admet-535	157	6	be	be	AUX
admet-535	157	7	successfully	successfully	ADV
admet-535	157	8	applied	apply	VERB
admet-535	157	9	in	in	ADP
admet-535	157	10	the	the	DET
admet-535	157	11	process	process	NOUN
admet-535	157	12	of	of	ADP
admet-535	157	13	identification	identification	NOUN
admet-535	157	14	of	of	ADP
admet-535	157	15	pharmacologically	pharmacologically	ADV
admet-535	157	16	active	active	ADJ
admet-535	157	17	compounds	compound	NOUN
admet-535	157	18	present	present	ADJ
admet-535	157	19	in	in	ADP
admet-535	157	20	complex	complex	ADJ
admet-535	157	21	natural	natural	ADJ
admet-535	157	22	matrices	matrix	NOUN
admet-535	157	23	targeting	target	VERB
admet-535	157	24	transmembrane	transmembrane	ADJ
admet-535	157	25	receptors	receptor	NOUN
admet-535	157	26	[	[	X
admet-535	157	27	7	7	NUM
admet-535	157	28	,	,	PUNCT
admet-535	157	29	46	46	NUM
admet-535	157	30	]	]	PUNCT
admet-535	157	31	.	.	PUNCT
admet-535	158	1	there	there	PRON
admet-535	158	2	are	be	VERB
admet-535	158	3	several	several	ADJ
admet-535	158	4	issues	issue	NOUN
admet-535	158	5	that	that	PRON
admet-535	158	6	need	need	VERB
admet-535	158	7	to	to	PART
admet-535	158	8	be	be	AUX
admet-535	158	9	taken	take	VERB
admet-535	158	10	into	into	ADP
admet-535	158	11	consideration	consideration	NOUN
admet-535	158	12	when	when	SCONJ
admet-535	158	13	applying	apply	VERB
admet-535	158	14	cmacs	cmac	NOUN
admet-535	158	15	in	in	ADP
admet-535	158	16	drug	drug	NOUN
admet-535	158	17	discovery	discovery	NOUN
admet-535	158	18	from	from	ADP
admet-535	158	19	natural	natural	ADJ
admet-535	158	20	samples	sample	NOUN
admet-535	158	21	.	.	PUNCT
admet-535	159	1	the	the	DET
admet-535	159	2	first	first	ADJ
admet-535	159	3	decision	decision	NOUN
admet-535	159	4	that	that	PRON
admet-535	159	5	has	have	VERB
admet-535	159	6	to	to	PART
admet-535	159	7	be	be	AUX
admet-535	159	8	made	make	VERB
admet-535	159	9	is	be	AUX
admet-535	159	10	in	in	ADP
admet-535	159	11	choosing	choose	VERB
admet-535	159	12	extracts	extract	NOUN
admet-535	159	13	that	that	PRON
admet-535	159	14	will	will	AUX
admet-535	159	15	be	be	AUX
admet-535	159	16	screened	screen	VERB
admet-535	159	17	using	use	VERB
admet-535	159	18	the	the	DET
admet-535	159	19	newly	newly	ADV
admet-535	159	20	developed	develop	VERB
admet-535	159	21	bioassay	bioassay	NOUN
admet-535	159	22	.	.	PUNCT
admet-535	160	1	the	the	DET
admet-535	160	2	samples	sample	NOUN
admet-535	160	3	to	to	PART
admet-535	160	4	be	be	AUX
admet-535	160	5	run	run	VERB
admet-535	160	6	on	on	ADP
admet-535	160	7	the	the	DET
admet-535	160	8	cmac	cmac	NOUN
admet-535	160	9	columns	column	NOUN
admet-535	160	10	should	should	AUX
admet-535	160	11	not	not	PART
admet-535	160	12	be	be	AUX
admet-535	160	13	random	random	ADJ
admet-535	160	14	,	,	PUNCT
admet-535	160	15	but	but	CCONJ
admet-535	160	16	carefully	carefully	ADV
admet-535	160	17	selected	select	VERB
admet-535	160	18	.	.	PUNCT
admet-535	161	1	plant	plant	NOUN
admet-535	161	2	extracts	extract	NOUN
admet-535	161	3	that	that	PRON
admet-535	161	4	previously	previously	ADV
admet-535	161	5	were	be	AUX
admet-535	161	6	reported	report	VERB
admet-535	161	7	to	to	PART
admet-535	161	8	exert	exert	VERB
admet-535	161	9	desired	desire	VERB
admet-535	161	10	pharmacological	pharmacological	ADJ
admet-535	161	11	activity	activity	NOUN
admet-535	161	12	may	may	AUX
admet-535	161	13	be	be	AUX
admet-535	161	14	considered	consider	VERB
admet-535	161	15	for	for	ADP
admet-535	161	16	the	the	DET
admet-535	161	17	screening	screening	NOUN
admet-535	161	18	experiments	experiment	NOUN
admet-535	161	19	.	.	PUNCT
admet-535	162	1	however	however	ADV
admet-535	162	2	,	,	PUNCT
admet-535	162	3	the	the	DET
admet-535	162	4	observed	observe	VERB
admet-535	162	5	biological	biological	ADJ
admet-535	162	6	effect	effect	NOUN
admet-535	162	7	may	may	AUX
admet-535	162	8	not	not	PART
admet-535	162	9	be	be	AUX
admet-535	162	10	from	from	ADP
admet-535	162	11	the	the	DET
admet-535	162	12	result	result	NOUN
admet-535	162	13	of	of	ADP
admet-535	162	14	the	the	DET
admet-535	162	15	interaction	interaction	NOUN
admet-535	162	16	of	of	ADP
admet-535	162	17	secondary	secondary	ADJ
admet-535	162	18	metabolites	metabolite	NOUN
admet-535	162	19	present	present	ADJ
admet-535	162	20	in	in	ADP
admet-535	162	21	the	the	DET
admet-535	162	22	extract	extract	NOUN
admet-535	162	23	and	and	CCONJ
admet-535	162	24	the	the	DET
admet-535	162	25	targeted	target	VERB
admet-535	162	26	protein	protein	NOUN
admet-535	162	27	,	,	PUNCT
admet-535	162	28	immobilized	immobilize	VERB
admet-535	162	29	on	on	ADP
admet-535	162	30	the	the	DET
admet-535	162	31	artificial	artificial	ADJ
admet-535	162	32	membrane	membrane	NOUN
admet-535	162	33	support	support	NOUN
admet-535	162	34	.	.	PUNCT
admet-535	163	1	another	another	DET
admet-535	163	2	idea	idea	NOUN
admet-535	163	3	of	of	ADP
admet-535	163	4	narrowing	narrow	VERB
admet-535	163	5	down	down	ADP
admet-535	163	6	the	the	DET
admet-535	163	7	possible	possible	ADJ
admet-535	163	8	screening	screening	NOUN
admet-535	163	9	extract	extract	NOUN
admet-535	163	10	candidates	candidate	NOUN
admet-535	163	11	is	be	AUX
admet-535	163	12	to	to	PART
admet-535	163	13	use	use	VERB
admet-535	163	14	a	a	DET
admet-535	163	15	simple	simple	ADJ
admet-535	163	16	in	in	ADP
admet-535	163	17	vivo	vivo	NOUN
admet-535	163	18	model	model	NOUN
admet-535	163	19	(	(	PUNCT
admet-535	163	20	c.	c.	PROPN
admet-535	163	21	elegans	elegan	NOUN
admet-535	163	22	or	or	CCONJ
admet-535	163	23	d.	d.	NOUN
admet-535	163	24	melanogaster	melanogaster	NOUN
admet-535	163	25	)	)	PUNCT
admet-535	163	26	and	and	CCONJ
admet-535	163	27	test	test	VERB
admet-535	163	28	the	the	DET
admet-535	163	29	extracts	extract	NOUN
admet-535	163	30	for	for	ADP
admet-535	163	31	biological	biological	ADJ
admet-535	163	32	activity	activity	NOUN
admet-535	163	33	.	.	PUNCT
admet-535	164	1	the	the	DET
admet-535	164	2	extracts	extract	NOUN
admet-535	164	3	that	that	PRON
admet-535	164	4	exert	exert	VERB
admet-535	164	5	the	the	DET
admet-535	164	6	biological	biological	ADJ
admet-535	164	7	effect	effect	NOUN
admet-535	164	8	are	be	AUX
admet-535	164	9	further	far	ADV
admet-535	164	10	screened	screen	VERB
admet-535	164	11	to	to	PART
admet-535	164	12	identify	identify	VERB
admet-535	164	13	phytochemicals	phytochemical	NOUN
admet-535	164	14	responsible	responsible	ADJ
admet-535	164	15	for	for	ADP
admet-535	164	16	this	this	DET
admet-535	164	17	effect	effect	NOUN
admet-535	164	18	.	.	PUNCT
admet-535	165	1	again	again	ADV
admet-535	165	2	,	,	PUNCT
admet-535	165	3	there	there	PRON
admet-535	165	4	has	have	VERB
admet-535	165	5	to	to	PART
admet-535	165	6	be	be	AUX
admet-535	165	7	a	a	DET
admet-535	165	8	known	know	VERB
admet-535	165	9	,	,	PUNCT
admet-535	165	10	or	or	CCONJ
admet-535	165	11	at	at	ADP
admet-535	165	12	least	least	ADJ
admet-535	165	13	a	a	DET
admet-535	165	14	rightfully	rightfully	ADV
admet-535	165	15	hypothesized	hypothesize	VERB
admet-535	165	16	connection	connection	NOUN
admet-535	165	17	between	between	ADP
admet-535	165	18	activation	activation	NOUN
admet-535	165	19	/	/	SYM
admet-535	165	20	inhibition	inhibition	NOUN
admet-535	165	21	of	of	ADP
admet-535	165	22	the	the	DET
admet-535	165	23	targeted	target	VERB
admet-535	165	24	transmembrane	transmembrane	ADJ
admet-535	165	25	protein	protein	NOUN
admet-535	165	26	and	and	CCONJ
admet-535	165	27	pharmacological	pharmacological	ADJ
admet-535	165	28	activity	activity	NOUN
admet-535	165	29	tested	test	VERB
admet-535	165	30	in	in	ADP
admet-535	165	31	the	the	DET
admet-535	165	32	in	in	ADJ
admet-535	165	33	vivo	vivo	NOUN
admet-535	165	34	model	model	NOUN
admet-535	165	35	.	.	PUNCT
admet-535	166	1	the	the	DET
admet-535	166	2	easiest	easy	ADJ
admet-535	166	3	way	way	NOUN
admet-535	166	4	to	to	PART
admet-535	166	5	check	check	VERB
admet-535	166	6	for	for	ADP
admet-535	166	7	the	the	DET
admet-535	166	8	possible	possible	ADJ
admet-535	166	9	presence	presence	NOUN
admet-535	166	10	of	of	ADP
admet-535	166	11	phytochemicals	phytochemical	NOUN
admet-535	166	12	interacting	interact	VERB
admet-535	166	13	with	with	ADP
admet-535	166	14	the	the	DET
admet-535	166	15	transmembrane	transmembrane	NOUN
admet-535	166	16	receptors	receptor	NOUN
admet-535	166	17	is	be	AUX
admet-535	166	18	to	to	PART
admet-535	166	19	use	use	VERB
admet-535	166	20	frontal	frontal	ADJ
admet-535	166	21	affinity	affinity	NOUN
admet-535	166	22	chromatography	chromatography	NOUN
admet-535	166	23	and	and	CCONJ
admet-535	166	24	a	a	DET
admet-535	166	25	marker	marker	NOUN
admet-535	166	26	ligand	ligand	NOUN
admet-535	166	27	known	know	VERB
admet-535	166	28	to	to	PART
admet-535	166	29	bind	bind	VERB
admet-535	166	30	to	to	ADP
admet-535	166	31	the	the	DET
admet-535	166	32	transmembrane	transmembrane	ADJ
admet-535	166	33	receptor	receptor	NOUN
admet-535	166	34	[	[	X
admet-535	166	35	7	7	NUM
admet-535	166	36	,	,	PUNCT
admet-535	166	37	30	30	NUM
admet-535	166	38	]	]	PUNCT
admet-535	166	39	.	.	PUNCT
admet-535	167	1	the	the	DET
admet-535	167	2	displacement	displacement	NOUN
admet-535	167	3	observed	observe	VERB
admet-535	167	4	after	after	ADP
admet-535	167	5	co	co	VERB
admet-535	167	6	-	-	VERB
admet-535	167	7	injecting	inject	VERB
admet-535	167	8	the	the	DET
admet-535	167	9	analysed	analyse	VERB
admet-535	167	10	extract	extract	NOUN
admet-535	167	11	and	and	CCONJ
admet-535	167	12	the	the	DET
admet-535	167	13	marker	marker	NOUN
admet-535	167	14	ligand	ligand	NOUN
admet-535	167	15	would	would	AUX
admet-535	167	16	indicate	indicate	VERB
admet-535	167	17	the	the	DET
admet-535	167	18	presence	presence	NOUN
admet-535	167	19	of	of	ADP
admet-535	167	20	phytochemicals	phytochemical	NOUN
admet-535	167	21	competing	compete	VERB
admet-535	167	22	with	with	ADP
admet-535	167	23	the	the	DET
admet-535	167	24	marker	marker	NOUN
admet-535	167	25	for	for	ADP
admet-535	167	26	the	the	DET
admet-535	167	27	binding	bind	VERB
admet-535	167	28	site	site	NOUN
admet-535	167	29	.	.	PUNCT
admet-535	168	1	this	this	DET
admet-535	168	2	approach	approach	NOUN
admet-535	168	3	can	can	AUX
admet-535	168	4	be	be	AUX
admet-535	168	5	applied	apply	VERB
admet-535	168	6	to	to	ADP
admet-535	168	7	screen	screen	NOUN
admet-535	168	8	extracts	extract	NOUN
admet-535	168	9	for	for	ADP
admet-535	168	10	compounds	compound	NOUN
admet-535	168	11	interacting	interact	VERB
admet-535	168	12	with	with	ADP
admet-535	168	13	both	both	CCONJ
admet-535	168	14	orthosteric	orthosteric	ADJ
admet-535	168	15	and	and	CCONJ
admet-535	168	16	allosteric	allosteric	ADJ
admet-535	168	17	binding	bind	VERB
admet-535	168	18	sites	site	NOUN
admet-535	168	19	.	.	PUNCT
admet-535	169	1	figure	figure	VERB
admet-535	169	2	6	6	NUM
admet-535	169	3	presents	present	VERB
admet-535	169	4	the	the	DET
admet-535	169	5	displacement	displacement	NOUN
admet-535	169	6	of	of	ADP
admet-535	169	7	mecamylamine	mecamylamine	NOUN
admet-535	169	8	,	,	PUNCT
admet-535	169	9	a	a	DET
admet-535	169	10	known	know	VERB
admet-535	169	11	nachr	nachr	PROPN
admet-535	169	12	allosteric	allosteric	ADJ
admet-535	169	13	inhibitor	inhibitor	NOUN
admet-535	169	14	displaced	displace	VERB
admet-535	169	15	by	by	ADP
admet-535	169	16	lycopodium	lycopodium	PROPN
admet-535	169	17	clavatum	clavatum	PROPN
admet-535	169	18	l.	l.	PROPN
admet-535	169	19	extract	extract	VERB
admet-535	169	20	on	on	ADP
admet-535	169	21	cmac	cmac	NOUN
admet-535	169	22	columns	column	NOUN
admet-535	169	23	with	with	ADP
admet-535	169	24	immobilized	immobilize	VERB
admet-535	169	25	two	two	NUM
admet-535	169	26	types	type	NOUN
admet-535	169	27	of	of	ADP
admet-535	169	28	nicotinic	nicotinic	ADJ
admet-535	169	29	receptors	receptor	NOUN
admet-535	169	30	α3β4	α3β4	NUM
admet-535	169	31	and	and	CCONJ
admet-535	169	32	α3β4α5	α3β4α5	VERB
admet-535	169	33	[	[	X
admet-535	169	34	30	30	NUM
admet-535	169	35	]	]	PUNCT
admet-535	169	36	.	.	PUNCT
admet-535	170	1	the	the	DET
admet-535	170	2	identification	identification	NOUN
admet-535	170	3	process	process	NOUN
admet-535	170	4	of	of	ADP
admet-535	170	5	individual	individual	ADJ
admet-535	170	6	secondary	secondary	ADJ
admet-535	170	7	metabolites	metabolite	NOUN
admet-535	170	8	responsible	responsible	ADJ
admet-535	170	9	for	for	ADP
admet-535	170	10	the	the	DET
admet-535	170	11	observed	observe	VERB
admet-535	170	12	displacement	displacement	NOUN
admet-535	170	13	of	of	ADP
admet-535	170	14	the	the	DET
admet-535	170	15	marker	marker	NOUN
admet-535	170	16	ligand	ligand	NOUN
admet-535	170	17	is	be	AUX
admet-535	170	18	performed	perform	VERB
admet-535	170	19	using	use	VERB
admet-535	170	20	the	the	DET
admet-535	170	21	“	"	PUNCT
admet-535	170	22	missing	missing	ADJ
admet-535	170	23	peak	peak	NOUN
admet-535	170	24	chromatography	chromatography	NOUN
admet-535	170	25	”	"	PUNCT
admet-535	170	26	approach	approach	NOUN
admet-535	170	27	[	[	X
admet-535	170	28	46	46	NUM
admet-535	170	29	]	]	PUNCT
admet-535	170	30	.	.	PUNCT
admet-535	171	1	one	one	NUM
admet-535	171	2	of	of	ADP
admet-535	171	3	the	the	DET
admet-535	171	4	greatest	great	ADJ
admet-535	171	5	challenges	challenge	NOUN
admet-535	171	6	in	in	ADP
admet-535	171	7	drug	drug	NOUN
admet-535	171	8	discovery	discovery	NOUN
admet-535	171	9	from	from	ADP
admet-535	171	10	plant	plant	NOUN
admet-535	171	11	extracts	extract	NOUN
admet-535	171	12	,	,	PUNCT
admet-535	171	13	using	use	VERB
admet-535	171	14	cmac	cmac	NOUN
admet-535	171	15	columns	column	NOUN
admet-535	171	16	,	,	PUNCT
admet-535	171	17	is	be	AUX
admet-535	171	18	discerning	discern	VERB
admet-535	171	19	specific	specific	ADJ
admet-535	171	20	interactions	interaction	NOUN
admet-535	171	21	(	(	PUNCT
admet-535	171	22	phytochemicals	phytochemical	NOUN
admet-535	171	23	interacting	interact	VERB
admet-535	171	24	with	with	ADP
admet-535	171	25	the	the	DET
admet-535	171	26	immobilized	immobilized	ADJ
admet-535	171	27	transmembrane	transmembrane	NOUN
admet-535	171	28	target	target	NOUN
admet-535	171	29	)	)	PUNCT
admet-535	171	30	from	from	ADP
admet-535	171	31	nonspecific	nonspecific	ADJ
admet-535	171	32	interactions	interaction	NOUN
admet-535	171	33	(	(	PUNCT
admet-535	171	34	compounds	compound	NOUN
admet-535	171	35	interacting	interact	VERB
admet-535	171	36	with	with	ADP
admet-535	171	37	iam	iam	PROPN
admet-535	171	38	particles	particle	NOUN
admet-535	171	39	or	or	CCONJ
admet-535	171	40	other	other	ADJ
admet-535	171	41	transmembrane	transmembrane	ADJ
admet-535	171	42	proteins	protein	NOUN
admet-535	171	43	coimmobilized	coimmobilize	VERB
admet-535	171	44	with	with	ADP
admet-535	171	45	the	the	DET
admet-535	171	46	studied	study	VERB
admet-535	171	47	targeted	target	VERB
admet-535	171	48	receptor	receptor	NOUN
admet-535	171	49	)	)	PUNCT
admet-535	171	50	.	.	PUNCT
admet-535	172	1	lipophilic	lipophilic	ADJ
admet-535	172	2	compounds	compound	NOUN
admet-535	172	3	have	have	AUX
admet-535	172	4	been	be	AUX
admet-535	172	5	found	find	VERB
admet-535	172	6	to	to	PART
admet-535	172	7	be	be	AUX
admet-535	172	8	strongly	strongly	ADV
admet-535	172	9	retained	retain	VERB
admet-535	172	10	on	on	ADP
admet-535	172	11	iam.pc	iam.pc	PROPN
admet-535	172	12	particles	particle	NOUN
admet-535	172	13	and	and	CCONJ
admet-535	172	14	an	an	DET
admet-535	172	15	alternative	alternative	ADJ
admet-535	172	16	approach	approach	NOUN
admet-535	172	17	has	have	AUX
admet-535	172	18	been	be	AUX
admet-535	172	19	proposed	propose	VERB
admet-535	172	20	to	to	PART
admet-535	172	21	study	study	VERB
admet-535	172	22	such	such	ADJ
admet-535	172	23	ligands	ligand	NOUN
admet-535	172	24	:	:	PUNCT
admet-535	172	25	immobilization	immobilization	NOUN
admet-535	172	26	of	of	ADP
admet-535	172	27	cell	cell	NOUN
admet-535	172	28	membrane	membrane	NOUN
admet-535	172	29	fragments	fragment	NOUN
admet-535	172	30	onto	onto	ADP
admet-535	172	31	the	the	DET
admet-535	172	32	surface	surface	NOUN
admet-535	172	33	of	of	ADP
admet-535	172	34	an	an	DET
admet-535	172	35	open	open	ADJ
admet-535	172	36	tubular	tubular	ADJ
admet-535	172	37	capillary	capillary	ADJ
admet-535	172	38	(	(	PUNCT
admet-535	172	39	ot	ot	NOUN
admet-535	172	40	columns	column	NOUN
admet-535	172	41	)	)	PUNCT
admet-535	173	1	[	[	X
admet-535	173	2	7	7	NUM
admet-535	173	3	]	]	PUNCT
admet-535	173	4	.	.	PUNCT
admet-535	174	1	for	for	ADP
admet-535	174	2	example	example	NOUN
admet-535	174	3	,	,	PUNCT
admet-535	174	4	ot	ot	ADP
admet-535	174	5	columns	column	NOUN
admet-535	174	6	were	be	AUX
admet-535	174	7	successfully	successfully	ADV
admet-535	174	8	used	use	VERB
admet-535	174	9	to	to	PART
admet-535	174	10	immobilize	immobilize	VERB
admet-535	174	11	cell	cell	NOUN
admet-535	174	12	membrane	membrane	NOUN
admet-535	174	13	fragments	fragment	NOUN
admet-535	174	14	with	with	ADP
admet-535	174	15	cb1	cb1	PROPN
admet-535	174	16	/	/	SYM
admet-535	174	17	cb2	cb2	NOUN
admet-535	174	18	receptors	receptor	NOUN
admet-535	174	19	and	and	CCONJ
admet-535	174	20	further	far	ADV
admet-535	174	21	for	for	ADP
admet-535	174	22	the	the	DET
admet-535	174	23	identification	identification	NOUN
admet-535	174	24	of	of	ADP
admet-535	174	25	endocannabinoid	endocannabinoid	ADJ
admet-535	174	26	receptor	receptor	NOUN
admet-535	174	27	ligands	ligand	NOUN
admet-535	174	28	from	from	ADP
admet-535	174	29	the	the	DET
admet-535	174	30	extract	extract	NOUN
admet-535	174	31	of	of	ADP
admet-535	174	32	zanthoxylum	zanthoxylum	PROPN
admet-535	174	33	clava	clava	PROPN
admet-535	174	34	-	-	PUNCT
admet-535	174	35	herculis	herculis	PROPN
admet-535	174	36	l.	l.	NOUN
admet-535	175	1	[	[	X
admet-535	175	2	34	34	NUM
admet-535	175	3	,	,	PUNCT
admet-535	175	4	47	47	NUM
admet-535	175	5	]	]	PUNCT
admet-535	175	6	.	.	PUNCT
admet-535	176	1	the	the	DET
admet-535	176	2	development	development	NOUN
admet-535	176	3	and	and	CCONJ
admet-535	176	4	the	the	DET
admet-535	176	5	use	use	NOUN
admet-535	176	6	of	of	ADP
admet-535	176	7	ot	ot	NOUN
admet-535	176	8	columns	column	NOUN
admet-535	176	9	remain	remain	VERB
admet-535	176	10	beyond	beyond	ADP
admet-535	176	11	the	the	DET
admet-535	176	12	scope	scope	NOUN
admet-535	176	13	of	of	ADP
admet-535	176	14	this	this	DET
admet-535	176	15	review	review	NOUN
admet-535	176	16	and	and	CCONJ
admet-535	176	17	interested	interested	ADJ
admet-535	176	18	readers	reader	NOUN
admet-535	176	19	are	be	AUX
admet-535	176	20	encouraged	encourage	VERB
admet-535	176	21	to	to	PART
admet-535	176	22	refer	refer	VERB
admet-535	176	23	to	to	ADP
admet-535	176	24	other	other	ADJ
admet-535	176	25	publications	publication	NOUN
admet-535	177	1	[	[	X
admet-535	177	2	7	7	NUM
admet-535	177	3	]	]	PUNCT
admet-535	177	4	.	.	PUNCT
admet-535	178	1	coimmobilization	coimmobilization	NOUN
admet-535	178	2	of	of	ADP
admet-535	178	3	other	other	ADJ
admet-535	178	4	proteins	protein	NOUN
admet-535	178	5	does	do	AUX
admet-535	178	6	not	not	PART
admet-535	178	7	need	need	VERB
admet-535	178	8	to	to	PART
admet-535	178	9	be	be	AUX
admet-535	178	10	considered	consider	VERB
admet-535	178	11	as	as	ADP
admet-535	178	12	a	a	DET
admet-535	178	13	cmac	cmac	NOUN
admet-535	178	14	disadvantage	disadvantage	NOUN
admet-535	178	15	,	,	PUNCT
admet-535	178	16	as	as	SCONJ
admet-535	178	17	the	the	DET
admet-535	178	18	same	same	ADJ
admet-535	178	19	column	column	NOUN
admet-535	178	20	can	can	AUX
admet-535	178	21	be	be	AUX
admet-535	178	22	utilized	utilize	VERB
admet-535	178	23	to	to	PART
admet-535	178	24	study	study	VERB
admet-535	178	25	compounds	compound	NOUN
admet-535	178	26	binding	bind	VERB
admet-535	178	27	to	to	ADP
admet-535	178	28	multiple	multiple	ADJ
admet-535	178	29	transmembrane	transmembrane	ADJ
admet-535	178	30	proteins	protein	NOUN
admet-535	178	31	[	[	X
admet-535	178	32	28	28	NUM
admet-535	178	33	]	]	PUNCT
admet-535	178	34	.	.	PUNCT
admet-535	179	1	to	to	PART
admet-535	179	2	admet	admet	PROPN
admet-535	179	3	&	&	CCONJ
admet-535	179	4	dmpk	dmpk	PROPN
admet-535	179	5	6(3	6(3	PROPN
admet-535	179	6	)	)	PUNCT
admet-535	179	7	(	(	PUNCT
admet-535	179	8	2018	2018	NUM
admet-535	179	9	)	)	PUNCT
admet-535	179	10	200	200	NUM
admet-535	179	11	-	-	SYM
admet-535	179	12	214	214	NUM
admet-535	179	13	cell	cell	NOUN
admet-535	179	14	membrane	membrane	NOUN
admet-535	179	15	affinity	affinity	NOUN
admet-535	179	16	chromatography	chromatography	NOUN
admet-535	179	17	in	in	ADP
admet-535	179	18	drug	drug	NOUN
admet-535	179	19	discovery	discovery	NOUN
admet-535	179	20	doi	doi	PROPN
admet-535	179	21	:	:	PUNCT
admet-535	179	22	10.5599	10.5599	NUM
admet-535	179	23	/	/	SYM
admet-535	179	24	admet.535	admet.535	PROPN
admet-535	179	25	209	209	NUM
admet-535	179	26	characterize	characterize	VERB
admet-535	179	27	multiple	multiple	ADJ
admet-535	179	28	proteins	protein	NOUN
admet-535	179	29	co	co	VERB
admet-535	179	30	-	-	VERB
admet-535	179	31	immobilized	immobilized	ADJ
admet-535	179	32	on	on	ADP
admet-535	179	33	the	the	DET
admet-535	179	34	iam	iam	PROPN
admet-535	179	35	particles	particle	NOUN
admet-535	179	36	,	,	PUNCT
admet-535	179	37	different	different	ADJ
admet-535	179	38	marker	marker	NOUN
admet-535	179	39	ligands	ligand	NOUN
admet-535	179	40	have	have	VERB
admet-535	179	41	to	to	PART
admet-535	179	42	be	be	AUX
admet-535	179	43	used	use	VERB
admet-535	179	44	,	,	PUNCT
admet-535	179	45	that	that	SCONJ
admet-535	179	46	specifically	specifically	ADV
admet-535	179	47	bind	bind	VERB
admet-535	179	48	to	to	ADP
admet-535	179	49	the	the	DET
admet-535	179	50	receptors	receptor	NOUN
admet-535	179	51	of	of	ADP
admet-535	179	52	interest	interest	NOUN
admet-535	179	53	.	.	PUNCT
admet-535	180	1	every	every	DET
admet-535	180	2	receptor	receptor	NOUN
admet-535	180	3	has	have	VERB
admet-535	180	4	to	to	PART
admet-535	180	5	be	be	AUX
admet-535	180	6	characterized	characterize	VERB
admet-535	180	7	in	in	ADP
admet-535	180	8	separate	separate	ADJ
admet-535	180	9	runs	run	NOUN
admet-535	180	10	.	.	PUNCT
admet-535	181	1	figure	figure	VERB
admet-535	181	2	6	6	NUM
admet-535	181	3	.	.	PUNCT
admet-535	182	1	frontal	frontal	ADJ
admet-535	182	2	elution	elution	NOUN
admet-535	182	3	profile	profile	NOUN
admet-535	182	4	of	of	ADP
admet-535	182	5	1	1	NUM
admet-535	182	6	µm	µm	ADP
admet-535	182	7	mecamylamine	mecamylamine	NOUN
admet-535	182	8	(	(	PUNCT
admet-535	182	9	i	i	NOUN
admet-535	182	10	)	)	PUNCT
admet-535	182	11	and	and	CCONJ
admet-535	182	12	1	1	NUM
admet-535	182	13	µm	µm	NUM
admet-535	182	14	mecamylamine	mecamylamine	NOUN
admet-535	182	15	+	+	CCONJ
admet-535	182	16	5	5	NUM
admet-535	182	17	%	%	NOUN
admet-535	182	18	lycopodium	lycopodium	NOUN
admet-535	182	19	clavatum	clavatum	PROPN
admet-535	182	20	(	(	PUNCT
admet-535	182	21	ii	ii	NOUN
admet-535	182	22	)	)	PUNCT
admet-535	182	23	on	on	ADP
admet-535	182	24	(	(	PUNCT
admet-535	182	25	a	a	X
admet-535	182	26	)	)	PUNCT
admet-535	182	27	the	the	DET
admet-535	182	28	α3β4	α3β4	NUM
admet-535	182	29	nicotinic	nicotinic	ADJ
admet-535	182	30	receptor	receptor	NOUN
admet-535	182	31	column	column	NOUN
admet-535	182	32	and	and	CCONJ
admet-535	182	33	(	(	PUNCT
admet-535	182	34	b	b	X
admet-535	182	35	)	)	PUNCT
admet-535	182	36	α3β4α5	α3β4α5	ADJ
admet-535	182	37	nicotinic	nicotinic	ADJ
admet-535	182	38	receptor	receptor	NOUN
admet-535	182	39	column	column	NOUN
admet-535	182	40	.	.	PUNCT
admet-535	183	1	for	for	SCONJ
admet-535	183	2	details	detail	NOUN
admet-535	183	3	please	please	INTJ
admet-535	183	4	refer	refer	VERB
admet-535	183	5	to	to	ADP
admet-535	183	6	the	the	DET
admet-535	183	7	paper	paper	NOUN
admet-535	183	8	by	by	ADP
admet-535	183	9	ciesla	ciesla	PROPN
admet-535	183	10	et	et	PROPN
admet-535	183	11	al	al	PROPN
admet-535	183	12	.	.	PUNCT
admet-535	184	1	[	[	X
admet-535	184	2	30	30	NUM
admet-535	184	3	]	]	PUNCT
admet-535	184	4	.	.	PUNCT
admet-535	185	1	with	with	ADP
admet-535	185	2	permission	permission	NOUN
admet-535	185	3	from	from	ADP
admet-535	185	4	[	[	X
admet-535	185	5	30	30	NUM
admet-535	185	6	]	]	PUNCT
admet-535	185	7	.	.	PUNCT
admet-535	186	1	the	the	DET
admet-535	186	2	missing	miss	VERB
admet-535	186	3	peak	peak	NOUN
admet-535	186	4	chromatography	chromatography	NOUN
admet-535	186	5	approach	approach	NOUN
admet-535	186	6	requires	require	VERB
admet-535	186	7	the	the	DET
admet-535	186	8	use	use	NOUN
admet-535	186	9	of	of	ADP
admet-535	186	10	a	a	DET
admet-535	186	11	negative	negative	ADJ
admet-535	186	12	control	control	NOUN
admet-535	186	13	cmac	cmac	NOUN
admet-535	186	14	column	column	NOUN
admet-535	186	15	,	,	PUNCT
admet-535	186	16	cmac(-	cmac(-	PROPN
admet-535	186	17	)	)	PUNCT
admet-535	186	18	.	.	PUNCT
admet-535	187	1	as	as	SCONJ
admet-535	187	2	previously	previously	ADV
admet-535	187	3	stated	state	VERB
admet-535	187	4	,	,	PUNCT
admet-535	187	5	transfected	transfecte	VERB
admet-535	187	6	cell	cell	NOUN
admet-535	187	7	lines	line	NOUN
admet-535	187	8	stably	stably	ADV
admet-535	187	9	overexpressing	overexpresse	VERB
admet-535	187	10	studied	study	VERB
admet-535	187	11	transmembrane	transmembrane	ADJ
admet-535	187	12	proteins	protein	NOUN
admet-535	187	13	are	be	AUX
admet-535	187	14	recommended	recommend	VERB
admet-535	187	15	for	for	ADP
admet-535	187	16	the	the	DET
admet-535	187	17	preparation	preparation	NOUN
admet-535	187	18	of	of	ADP
admet-535	187	19	cmac	cmac	NOUN
admet-535	187	20	columns	column	NOUN
admet-535	187	21	.	.	PUNCT
admet-535	188	1	a	a	DET
admet-535	188	2	negative	negative	ADJ
admet-535	188	3	control	control	NOUN
admet-535	188	4	column	column	NOUN
admet-535	188	5	(	(	PUNCT
admet-535	188	6	cmac(-	cmac(-	NOUN
admet-535	188	7	)	)	PUNCT
admet-535	188	8	)	)	PUNCT
admet-535	188	9	is	be	AUX
admet-535	188	10	prepared	prepare	VERB
admet-535	188	11	using	use	VERB
admet-535	188	12	the	the	DET
admet-535	188	13	same	same	ADJ
admet-535	188	14	cell	cell	NOUN
admet-535	188	15	line	line	NOUN
admet-535	188	16	,	,	PUNCT
admet-535	188	17	however	however	ADV
admet-535	188	18	not	not	PART
admet-535	188	19	expressing	express	VERB
admet-535	188	20	the	the	DET
admet-535	188	21	receptors	receptor	NOUN
admet-535	188	22	overexpressed	overexpresse	VERB
admet-535	188	23	by	by	ADP
admet-535	188	24	the	the	DET
admet-535	188	25	transfected	transfecte	VERB
admet-535	188	26	line	line	NOUN
admet-535	188	27	.	.	PUNCT
admet-535	189	1	for	for	ADP
admet-535	189	2	example	example	NOUN
admet-535	189	3	,	,	PUNCT
admet-535	189	4	in	in	ADP
admet-535	189	5	the	the	DET
admet-535	189	6	case	case	NOUN
admet-535	189	7	of	of	ADP
admet-535	189	8	nachr	nachr	PROPN
admet-535	189	9	cmac	cmac	NOUN
admet-535	189	10	columns	column	NOUN
admet-535	189	11	,	,	PUNCT
admet-535	189	12	hek	hek	PROPN
admet-535	189	13	cells	cell	NOUN
admet-535	189	14	overexpressing	overexpresse	VERB
admet-535	189	15	desired	desire	VERB
admet-535	189	16	nachr	nachr	PROPN
admet-535	189	17	subtypes	subtype	NOUN
admet-535	189	18	were	be	AUX
admet-535	189	19	used	use	VERB
admet-535	189	20	cayman	cayman	NOUN
admet-535	189	21	,	,	PUNCT
admet-535	189	22	omri	omri	PROPN
admet-535	189	23	&	&	CCONJ
admet-535	189	24	ciesla	ciesla	PROPN
admet-535	189	25	admet	admet	PROPN
admet-535	189	26	&	&	CCONJ
admet-535	189	27	dmpk	dmpk	PROPN
admet-535	189	28	6(3	6(3	PROPN
admet-535	189	29	)	)	PUNCT
admet-535	189	30	(	(	PUNCT
admet-535	189	31	2018	2018	NUM
admet-535	189	32	)	)	PUNCT
admet-535	189	33	200	200	NUM
admet-535	189	34	-	-	SYM
admet-535	189	35	214	214	NUM
admet-535	189	36	210	210	NUM
admet-535	189	37	to	to	PART
admet-535	189	38	prepare	prepare	VERB
admet-535	189	39	cmac(+	cmac(+	NOUN
admet-535	189	40	)	)	PUNCT
admet-535	189	41	,	,	PUNCT
admet-535	189	42	while	while	SCONJ
admet-535	189	43	hek	hek	PROPN
admet-535	189	44	293	293	NUM
admet-535	189	45	cells	cell	NOUN
admet-535	189	46	were	be	AUX
admet-535	189	47	utilized	utilize	VERB
admet-535	189	48	to	to	PART
admet-535	189	49	develop	develop	VERB
admet-535	189	50	cmac(-	cmac(-	NOUN
admet-535	189	51	)	)	PUNCT
admet-535	190	1	[	[	X
admet-535	190	2	30	30	NUM
admet-535	190	3	]	]	PUNCT
admet-535	190	4	.	.	PUNCT
admet-535	191	1	in	in	ADP
admet-535	191	2	the	the	DET
admet-535	191	3	missing	miss	VERB
admet-535	191	4	peak	peak	NOUN
admet-535	191	5	chromatography	chromatography	NOUN
admet-535	191	6	technique	technique	NOUN
admet-535	191	7	,	,	PUNCT
admet-535	191	8	plant	plant	NOUN
admet-535	191	9	extracts	extract	NOUN
admet-535	191	10	are	be	AUX
admet-535	191	11	chromatographed	chromatographe	VERB
admet-535	191	12	on	on	ADP
admet-535	191	13	cmac(+	cmac(+	NOUN
admet-535	191	14	)	)	PUNCT
admet-535	191	15	and	and	CCONJ
admet-535	191	16	cmac(-	cmac(-	NOUN
admet-535	191	17	)	)	PUNCT
admet-535	191	18	columns	column	NOUN
admet-535	191	19	using	use	VERB
admet-535	191	20	ammonium	ammonium	NOUN
admet-535	191	21	acetate	acetate	NOUN
admet-535	191	22	buffer	buffer	NOUN
admet-535	191	23	(	(	PUNCT
admet-535	191	24	10	10	NUM
admet-535	191	25	mm	mm	NOUN
admet-535	191	26	,	,	PUNCT
admet-535	191	27	ph	ph	NOUN
admet-535	191	28	7.4	7.4	NUM
admet-535	191	29	)	)	PUNCT
admet-535	191	30	delivered	deliver	VERB
admet-535	191	31	at	at	ADP
admet-535	191	32	0.2	0.2	NUM
admet-535	191	33	ml	ml	NOUN
admet-535	191	34	/	/	SYM
admet-535	191	35	min	min	NOUN
admet-535	191	36	as	as	ADP
admet-535	191	37	mobile	mobile	ADJ
admet-535	191	38	phase	phase	NOUN
admet-535	191	39	[	[	X
admet-535	191	40	46	46	NUM
admet-535	191	41	]	]	PUNCT
admet-535	191	42	.	.	PUNCT
admet-535	192	1	fractions	fraction	NOUN
admet-535	192	2	are	be	AUX
admet-535	192	3	collected	collect	VERB
admet-535	192	4	based	base	VERB
admet-535	192	5	on	on	ADP
admet-535	192	6	the	the	DET
admet-535	192	7	observed	observe	VERB
admet-535	192	8	chromatograms	chromatogram	NOUN
admet-535	192	9	.	.	PUNCT
admet-535	193	1	the	the	DET
admet-535	193	2	obtained	obtain	VERB
admet-535	193	3	fractions	fraction	NOUN
admet-535	193	4	are	be	AUX
admet-535	193	5	subsequently	subsequently	ADV
admet-535	193	6	fingerprinted	fingerprint	VERB
admet-535	193	7	on	on	ADP
admet-535	193	8	c18	c18	NOUN
admet-535	193	9	columns	column	NOUN
admet-535	193	10	and	and	CCONJ
admet-535	193	11	the	the	DET
admet-535	193	12	fingerprints	fingerprint	NOUN
admet-535	193	13	obtained	obtain	VERB
admet-535	193	14	using	use	VERB
admet-535	193	15	cmac(+	cmac(+	NOUN
admet-535	193	16	)	)	PUNCT
admet-535	193	17	and	and	CCONJ
admet-535	193	18	cmac(-	cmac(-	PROPN
admet-535	193	19	)	)	PUNCT
admet-535	193	20	are	be	AUX
admet-535	193	21	compared	compare	VERB
admet-535	193	22	.	.	PUNCT
admet-535	194	1	the	the	DET
admet-535	194	2	difference	difference	NOUN
admet-535	194	3	between	between	ADP
admet-535	194	4	the	the	DET
admet-535	194	5	cmac(+	cmac(+	NOUN
admet-535	194	6	)	)	PUNCT
admet-535	194	7	and	and	CCONJ
admet-535	194	8	cmac(−	cmac(−	PROPN
admet-535	194	9	)	)	PUNCT
admet-535	194	10	columns	column	NOUN
admet-535	194	11	is	be	AUX
admet-535	194	12	in	in	ADP
admet-535	194	13	the	the	DET
admet-535	194	14	availability	availability	NOUN
admet-535	194	15	of	of	ADP
admet-535	194	16	the	the	DET
admet-535	194	17	immobilized	immobilized	ADJ
admet-535	194	18	protein	protein	NOUN
admet-535	194	19	target	target	NOUN
admet-535	194	20	.	.	PUNCT
admet-535	195	1	the	the	DET
admet-535	195	2	differences	difference	NOUN
admet-535	195	3	in	in	ADP
admet-535	195	4	the	the	DET
admet-535	195	5	retention	retention	NOUN
admet-535	195	6	of	of	ADP
admet-535	195	7	a	a	DET
admet-535	195	8	compound	compound	NOUN
admet-535	195	9	on	on	ADP
admet-535	195	10	the	the	DET
admet-535	195	11	cmac(+	cmac(+	NOUN
admet-535	195	12	)	)	PUNCT
admet-535	195	13	column	column	NOUN
admet-535	195	14	relative	relative	ADJ
admet-535	195	15	to	to	ADP
admet-535	195	16	the	the	DET
admet-535	195	17	cmac(−	cmac(−	PROPN
admet-535	195	18	)	)	PUNCT
admet-535	195	19	column	column	NOUN
admet-535	195	20	is	be	AUX
admet-535	195	21	due	due	ADJ
admet-535	195	22	to	to	ADP
admet-535	195	23	specific	specific	ADJ
admet-535	195	24	interactions	interaction	NOUN
admet-535	195	25	with	with	ADP
admet-535	195	26	the	the	DET
admet-535	195	27	target	target	NOUN
admet-535	195	28	[	[	X
admet-535	195	29	7	7	NUM
admet-535	195	30	,	,	PUNCT
admet-535	195	31	46	46	NUM
admet-535	195	32	]	]	PUNCT
admet-535	195	33	.	.	PUNCT
admet-535	196	1	a	a	DET
admet-535	196	2	peak	peak	NOUN
admet-535	196	3	that	that	PRON
admet-535	196	4	is	be	AUX
admet-535	196	5	missing	miss	VERB
admet-535	196	6	in	in	ADP
admet-535	196	7	the	the	DET
admet-535	196	8	fingerprint	fingerprint	NOUN
admet-535	196	9	of	of	ADP
admet-535	196	10	a	a	DET
admet-535	196	11	cmac(+	cmac(+	NOUN
admet-535	196	12	)	)	PUNCT
admet-535	196	13	early	early	ADJ
admet-535	196	14	fraction	fraction	NOUN
admet-535	196	15	,	,	PUNCT
admet-535	196	16	but	but	CCONJ
admet-535	196	17	present	present	ADJ
admet-535	196	18	in	in	ADP
admet-535	196	19	the	the	DET
admet-535	196	20	control	control	NOUN
admet-535	196	21	and	and	CCONJ
admet-535	196	22	corresponding	corresponding	ADJ
admet-535	196	23	cmac(−	cmac(−	PROPN
admet-535	196	24	)	)	PUNCT
admet-535	196	25	early	early	ADJ
admet-535	196	26	fraction	fraction	NOUN
admet-535	196	27	,	,	PUNCT
admet-535	196	28	is	be	AUX
admet-535	196	29	considered	consider	VERB
admet-535	196	30	to	to	PART
admet-535	196	31	bind	bind	VERB
admet-535	196	32	to	to	ADP
admet-535	196	33	the	the	DET
admet-535	196	34	immobilized	immobilized	ADJ
admet-535	196	35	transmembrane	transmembrane	ADJ
admet-535	196	36	protein	protein	NOUN
admet-535	196	37	target	target	NOUN
admet-535	196	38	on	on	ADP
admet-535	196	39	the	the	DET
admet-535	196	40	cmac(+	cmac(+	NOUN
admet-535	196	41	)	)	PUNCT
admet-535	196	42	column	column	NOUN
admet-535	197	1	[	[	X
admet-535	197	2	46	46	NUM
admet-535	197	3	]	]	PUNCT
admet-535	197	4	.	.	PUNCT
admet-535	198	1	elution	elution	NOUN
admet-535	198	2	of	of	ADP
admet-535	198	3	this	this	DET
admet-535	198	4	particular	particular	ADJ
admet-535	198	5	compound	compound	NOUN
admet-535	198	6	in	in	ADP
admet-535	198	7	a	a	DET
admet-535	198	8	later	later	ADJ
admet-535	198	9	fraction	fraction	NOUN
admet-535	198	10	of	of	ADP
admet-535	198	11	cmac(+	cmac(+	NOUN
admet-535	198	12	)	)	PUNCT
admet-535	198	13	,	,	PUNCT
admet-535	198	14	along	along	ADP
admet-535	198	15	with	with	ADP
admet-535	198	16	its	its	PRON
admet-535	198	17	absence	absence	NOUN
admet-535	198	18	in	in	ADP
admet-535	198	19	the	the	DET
admet-535	198	20	corresponding	corresponding	ADJ
admet-535	198	21	fraction	fraction	NOUN
admet-535	198	22	in	in	ADP
admet-535	198	23	cmac(−	cmac(−	PROPN
admet-535	198	24	)	)	PUNCT
admet-535	198	25	,	,	PUNCT
admet-535	198	26	is	be	AUX
admet-535	198	27	a	a	DET
admet-535	198	28	further	further	ADJ
admet-535	198	29	confirmation	confirmation	NOUN
admet-535	198	30	of	of	ADP
admet-535	198	31	the	the	DET
admet-535	198	32	affinity	affinity	NOUN
admet-535	198	33	of	of	ADP
admet-535	198	34	this	this	DET
admet-535	198	35	compound	compound	NOUN
admet-535	198	36	for	for	ADP
admet-535	198	37	the	the	DET
admet-535	198	38	targeted	target	VERB
admet-535	198	39	transmembrane	transmembrane	ADJ
admet-535	198	40	receptor	receptor	NOUN
admet-535	198	41	in	in	ADP
admet-535	198	42	cmac(+	cmac(+	NOUN
admet-535	198	43	)	)	PUNCT
admet-535	199	1	[	[	X
admet-535	199	2	46	46	NUM
admet-535	199	3	]	]	PUNCT
admet-535	199	4	.	.	PUNCT
admet-535	200	1	compounds	compound	NOUN
admet-535	200	2	identified	identify	VERB
admet-535	200	3	as	as	ADP
admet-535	200	4	specifically	specifically	ADV
admet-535	200	5	binding	bind	VERB
admet-535	200	6	to	to	ADP
admet-535	200	7	the	the	DET
admet-535	200	8	studied	study	VERB
admet-535	200	9	receptors	receptor	NOUN
admet-535	200	10	can	can	AUX
admet-535	200	11	be	be	AUX
admet-535	200	12	subsequently	subsequently	ADV
admet-535	200	13	isolated	isolate	VERB
admet-535	200	14	using	use	VERB
admet-535	200	15	analytical	analytical	ADJ
admet-535	200	16	or	or	CCONJ
admet-535	200	17	semipreparative	semipreparative	ADJ
admet-535	200	18	hplc	hplc	NOUN
admet-535	200	19	,	,	PUNCT
admet-535	200	20	their	their	PRON
admet-535	200	21	structures	structure	NOUN
admet-535	200	22	elucidated	elucidate	VERB
admet-535	200	23	and	and	CCONJ
admet-535	200	24	further	far	ADV
admet-535	200	25	tested	test	VERB
admet-535	200	26	in	in	ADP
admet-535	200	27	functional	functional	ADJ
admet-535	200	28	assays	assay	NOUN
admet-535	200	29	or	or	CCONJ
admet-535	200	30	in	in	ADP
admet-535	200	31	vivo	vivo	NOUN
admet-535	200	32	models	model	NOUN
admet-535	200	33	.	.	PUNCT
admet-535	201	1	cmac	cmac	NOUN
admet-535	201	2	chromatography	chromatography	NOUN
admet-535	201	3	columns	column	NOUN
admet-535	201	4	with	with	ADP
admet-535	201	5	immobilized	immobilized	ADJ
admet-535	201	6	cell	cell	NOUN
admet-535	201	7	membrane	membrane	NOUN
admet-535	201	8	fragments	fragment	NOUN
admet-535	201	9	on	on	ADP
admet-535	201	10	iam	iam	PROPN
admet-535	201	11	particles	particle	NOUN
admet-535	201	12	do	do	AUX
admet-535	201	13	not	not	PART
admet-535	201	14	solve	solve	VERB
admet-535	201	15	all	all	PRON
admet-535	201	16	of	of	ADP
admet-535	201	17	the	the	DET
admet-535	201	18	problems	problem	NOUN
admet-535	201	19	in	in	ADP
admet-535	201	20	the	the	DET
admet-535	201	21	drug	drug	NOUN
admet-535	201	22	discovery	discovery	NOUN
admet-535	201	23	process	process	NOUN
admet-535	201	24	from	from	ADP
admet-535	201	25	natural	natural	ADJ
admet-535	201	26	samples	sample	NOUN
admet-535	201	27	.	.	PUNCT
admet-535	202	1	this	this	DET
admet-535	202	2	approach	approach	NOUN
admet-535	202	3	requires	require	VERB
admet-535	202	4	the	the	DET
admet-535	202	5	use	use	NOUN
admet-535	202	6	of	of	ADP
admet-535	202	7	negative	negative	ADJ
admet-535	202	8	control	control	NOUN
admet-535	202	9	columns	column	NOUN
admet-535	202	10	and	and	CCONJ
admet-535	202	11	the	the	DET
admet-535	202	12	solvent	solvent	ADJ
admet-535	202	13	choice	choice	NOUN
admet-535	202	14	is	be	AUX
admet-535	202	15	limited	limit	VERB
admet-535	202	16	to	to	ADP
admet-535	202	17	buffered	buffer	VERB
admet-535	202	18	aqueous	aqueous	ADJ
admet-535	202	19	solvents	solvent	NOUN
admet-535	202	20	(	(	PUNCT
admet-535	202	21	with	with	ADP
admet-535	202	22	only	only	ADV
admet-535	202	23	up	up	ADP
admet-535	202	24	to	to	ADP
admet-535	202	25	approx	approx	PROPN
admet-535	202	26	.	.	PUNCT
admet-535	203	1	10	10	NUM
admet-535	203	2	%	%	NOUN
admet-535	203	3	of	of	ADP
admet-535	203	4	organic	organic	ADJ
admet-535	203	5	modifier	modifier	NOUN
admet-535	203	6	)	)	PUNCT
admet-535	203	7	.	.	PUNCT
admet-535	204	1	cmac	cmac	NOUN
admet-535	204	2	columns	column	NOUN
admet-535	204	3	,	,	PUNCT
admet-535	204	4	however	however	ADV
admet-535	204	5	,	,	PUNCT
admet-535	204	6	do	do	AUX
admet-535	204	7	speed	speed	VERB
admet-535	204	8	up	up	ADP
admet-535	204	9	the	the	DET
admet-535	204	10	process	process	NOUN
admet-535	204	11	of	of	ADP
admet-535	204	12	target	target	NOUN
admet-535	204	13	identification	identification	NOUN
admet-535	204	14	,	,	PUNCT
admet-535	204	15	without	without	ADP
admet-535	204	16	the	the	DET
admet-535	204	17	need	need	NOUN
admet-535	204	18	to	to	PART
admet-535	204	19	isolate	isolate	VERB
admet-535	204	20	individual	individual	ADJ
admet-535	204	21	compounds	compound	NOUN
admet-535	204	22	and	and	CCONJ
admet-535	204	23	test	test	VERB
admet-535	204	24	them	they	PRON
admet-535	204	25	separately	separately	ADV
admet-535	204	26	using	use	VERB
admet-535	204	27	different	different	ADJ
admet-535	204	28	assays	assay	NOUN
admet-535	204	29	.	.	PUNCT
admet-535	205	1	cmac	cmac	NOUN
admet-535	205	2	is	be	AUX
admet-535	205	3	an	an	DET
admet-535	205	4	assay	assay	NOUN
admet-535	205	5	,	,	PUNCT
admet-535	205	6	in	in	ADP
admet-535	205	7	which	which	PRON
admet-535	205	8	transmembrane	transmembrane	ADJ
admet-535	205	9	proteins	protein	NOUN
admet-535	205	10	remain	remain	VERB
admet-535	205	11	submerged	submerged	ADJ
admet-535	205	12	in	in	ADP
admet-535	205	13	a	a	DET
admet-535	205	14	natural	natural	ADJ
admet-535	205	15	lipid	lipid	NOUN
admet-535	205	16	environment	environment	NOUN
admet-535	205	17	,	,	PUNCT
admet-535	205	18	in	in	ADP
admet-535	205	19	close	close	ADV
admet-535	205	20	to	to	ADP
admet-535	205	21	physiological	physiological	ADJ
admet-535	205	22	conditions	condition	NOUN
admet-535	205	23	.	.	PUNCT
admet-535	206	1	cmac	cmac	NOUN
admet-535	206	2	columns	column	NOUN
admet-535	206	3	allow	allow	VERB
admet-535	206	4	for	for	ADP
admet-535	206	5	the	the	DET
admet-535	206	6	identification	identification	NOUN
admet-535	206	7	of	of	ADP
admet-535	206	8	compounds	compound	NOUN
admet-535	206	9	binding	bind	VERB
admet-535	206	10	to	to	ADP
admet-535	206	11	receptor	receptor	NOUN
admet-535	206	12	subtypes	subtype	NOUN
admet-535	206	13	.	.	PUNCT
admet-535	207	1	after	after	ADP
admet-535	207	2	identification	identification	NOUN
admet-535	207	3	and	and	CCONJ
admet-535	207	4	isolation	isolation	NOUN
admet-535	207	5	of	of	ADP
admet-535	207	6	pharmacologically	pharmacologically	ADV
admet-535	207	7	active	active	ADJ
admet-535	207	8	phytochemicals	phytochemical	NOUN
admet-535	207	9	,	,	PUNCT
admet-535	207	10	cmac	cmac	NOUN
admet-535	207	11	columns	column	NOUN
admet-535	207	12	may	may	AUX
admet-535	207	13	be	be	AUX
admet-535	207	14	used	use	VERB
admet-535	207	15	to	to	PART
admet-535	207	16	study	study	VERB
admet-535	207	17	their	their	PRON
admet-535	207	18	interaction	interaction	NOUN
admet-535	207	19	with	with	ADP
admet-535	207	20	the	the	DET
admet-535	207	21	immobilized	immobilized	ADJ
admet-535	207	22	protein	protein	NOUN
admet-535	207	23	target	target	NOUN
admet-535	207	24	(	(	PUNCT
admet-535	207	25	obtaining	obtain	VERB
admet-535	207	26	pharmacodynamics	pharmacodynamic	NOUN
admet-535	207	27	and	and	CCONJ
admet-535	207	28	pharmacokinetic	pharmacokinetic	ADJ
admet-535	207	29	data	datum	NOUN
admet-535	207	30	)	)	PUNCT
admet-535	207	31	.	.	PUNCT
admet-535	208	1	the	the	DET
admet-535	208	2	drug	drug	NOUN
admet-535	208	3	discovery	discovery	NOUN
admet-535	208	4	process	process	NOUN
admet-535	208	5	with	with	ADP
admet-535	208	6	cmacs	cmacs	PROPN
admet-535	208	7	is	be	AUX
admet-535	208	8	a	a	DET
admet-535	208	9	targetoriented	targetoriente	VERB
admet-535	208	10	technique	technique	NOUN
admet-535	208	11	,	,	PUNCT
admet-535	208	12	ideally	ideally	ADV
admet-535	208	13	suited	suit	VERB
admet-535	208	14	for	for	ADP
admet-535	208	15	creating	create	VERB
admet-535	208	16	libraries	library	NOUN
admet-535	208	17	of	of	ADP
admet-535	208	18	natural	natural	ADJ
admet-535	208	19	compounds	compound	NOUN
admet-535	208	20	interacting	interact	VERB
admet-535	208	21	with	with	ADP
admet-535	208	22	a	a	DET
admet-535	208	23	specific	specific	ADJ
admet-535	208	24	cell	cell	NOUN
admet-535	208	25	membrane	membrane	NOUN
admet-535	208	26	target	target	NOUN
admet-535	208	27	.	.	PUNCT
admet-535	209	1	future	future	ADJ
admet-535	209	2	directions	direction	NOUN
admet-535	209	3	the	the	DET
admet-535	209	4	potential	potential	NOUN
admet-535	209	5	of	of	ADP
admet-535	209	6	cell	cell	NOUN
admet-535	209	7	membrane	membrane	NOUN
admet-535	209	8	affinity	affinity	NOUN
admet-535	209	9	chromatography	chromatography	NOUN
admet-535	209	10	columns	column	NOUN
admet-535	209	11	in	in	ADP
admet-535	209	12	the	the	DET
admet-535	209	13	drug	drug	NOUN
admet-535	209	14	discovery	discovery	NOUN
admet-535	209	15	process	process	NOUN
admet-535	209	16	from	from	ADP
admet-535	209	17	natural	natural	ADJ
admet-535	209	18	samples	sample	NOUN
admet-535	209	19	has	have	AUX
admet-535	209	20	been	be	AUX
admet-535	209	21	underestimated	underestimate	VERB
admet-535	209	22	.	.	PUNCT
admet-535	210	1	pharmaceutical	pharmaceutical	ADJ
admet-535	210	2	companies	company	NOUN
admet-535	210	3	have	have	AUX
admet-535	210	4	focused	focus	VERB
admet-535	210	5	their	their	PRON
admet-535	210	6	discovery	discovery	NOUN
admet-535	210	7	programs	program	NOUN
admet-535	210	8	on	on	ADP
admet-535	210	9	automated	automate	VERB
admet-535	210	10	high	high	ADJ
admet-535	210	11	-	-	PUNCT
admet-535	210	12	throughput	throughput	NOUN
admet-535	210	13	screening	screening	NOUN
admet-535	210	14	techniques	technique	NOUN
admet-535	210	15	(	(	PUNCT
admet-535	210	16	hts	hts	PROPN
admet-535	210	17	)	)	PUNCT
admet-535	210	18	,	,	PUNCT
admet-535	210	19	which	which	PRON
admet-535	210	20	are	be	AUX
admet-535	210	21	not	not	PART
admet-535	210	22	suitable	suitable	ADJ
admet-535	210	23	for	for	ADP
admet-535	210	24	complex	complex	ADJ
admet-535	210	25	matrices	matrix	NOUN
admet-535	210	26	.	.	PUNCT
admet-535	211	1	however	however	ADV
admet-535	211	2	,	,	PUNCT
admet-535	211	3	the	the	DET
admet-535	211	4	introduction	introduction	NOUN
admet-535	211	5	of	of	ADP
admet-535	211	6	hts	hts	PROPN
admet-535	211	7	techniques	technique	NOUN
admet-535	211	8	did	do	AUX
admet-535	211	9	not	not	PART
admet-535	211	10	result	result	VERB
admet-535	211	11	in	in	ADP
admet-535	211	12	the	the	DET
admet-535	211	13	predicted	predict	VERB
admet-535	211	14	substantial	substantial	ADJ
admet-535	211	15	increase	increase	NOUN
admet-535	211	16	of	of	ADP
admet-535	211	17	new	new	ADJ
admet-535	211	18	classes	class	NOUN
admet-535	211	19	of	of	ADP
admet-535	211	20	drugs	drug	NOUN
admet-535	211	21	entering	enter	VERB
admet-535	211	22	the	the	DET
admet-535	211	23	market	market	NOUN
admet-535	211	24	[	[	X
admet-535	211	25	8	8	NUM
admet-535	211	26	]	]	PUNCT
admet-535	211	27	.	.	PUNCT
admet-535	212	1	secondary	secondary	ADJ
admet-535	212	2	metabolites	metabolite	NOUN
admet-535	212	3	are	be	AUX
admet-535	212	4	evolutionary	evolutionary	ADJ
admet-535	212	5	-	-	PUNCT
admet-535	212	6	designed	design	VERB
admet-535	212	7	compounds	compound	NOUN
admet-535	212	8	targeting	target	VERB
admet-535	212	9	specific	specific	ADJ
admet-535	212	10	,	,	PUNCT
admet-535	212	11	often	often	ADV
admet-535	212	12	highly	highly	ADV
admet-535	212	13	-	-	PUNCT
admet-535	212	14	conserved	conserved	ADJ
admet-535	212	15	signalling	signal	VERB
admet-535	212	16	pathways	pathway	NOUN
admet-535	212	17	and	and	CCONJ
admet-535	212	18	are	be	AUX
admet-535	212	19	already	already	ADV
admet-535	212	20	optimized	optimize	VERB
admet-535	212	21	to	to	PART
admet-535	212	22	be	be	AUX
admet-535	212	23	pharmacologically	pharmacologically	ADV
admet-535	212	24	active	active	ADJ
admet-535	212	25	.	.	PUNCT
admet-535	213	1	one	one	NUM
admet-535	213	2	of	of	ADP
admet-535	213	3	the	the	DET
admet-535	213	4	ways	way	NOUN
admet-535	213	5	of	of	ADP
admet-535	213	6	unravelling	unravel	VERB
admet-535	213	7	the	the	DET
admet-535	213	8	mysteries	mystery	NOUN
admet-535	213	9	of	of	ADP
admet-535	213	10	natural	natural	ADJ
admet-535	213	11	compounds	compound	NOUN
admet-535	213	12	is	be	AUX
admet-535	213	13	to	to	PART
admet-535	213	14	develop	develop	VERB
admet-535	213	15	approaches	approach	NOUN
admet-535	213	16	enabling	enable	VERB
admet-535	213	17	identification	identification	NOUN
admet-535	213	18	of	of	ADP
admet-535	213	19	these	these	DET
admet-535	213	20	phytochemicals	phytochemical	NOUN
admet-535	213	21	.	.	PUNCT
admet-535	214	1	cellular	cellular	ADJ
admet-535	214	2	membrane	membrane	NOUN
admet-535	214	3	affinity	affinity	NOUN
admet-535	214	4	chromatography	chromatography	NOUN
admet-535	214	5	columns	column	NOUN
admet-535	214	6	allow	allow	VERB
admet-535	214	7	phytochemists	phytochemist	NOUN
admet-535	214	8	to	to	PART
admet-535	214	9	selectively	selectively	ADV
admet-535	214	10	identify	identify	VERB
admet-535	214	11	compounds	compound	NOUN
admet-535	214	12	interacting	interact	VERB
admet-535	214	13	with	with	ADP
admet-535	214	14	transmembrane	transmembrane	ADJ
admet-535	214	15	proteins	protein	NOUN
admet-535	214	16	.	.	PUNCT
admet-535	215	1	we	we	PRON
admet-535	215	2	predict	predict	VERB
admet-535	215	3	cmac	cmac	NOUN
admet-535	215	4	columns	column	NOUN
admet-535	215	5	have	have	VERB
admet-535	215	6	a	a	DET
admet-535	215	7	potential	potential	NOUN
admet-535	215	8	to	to	PART
admet-535	215	9	become	become	VERB
admet-535	215	10	the	the	DET
admet-535	215	11	next	next	ADJ
admet-535	215	12	generation	generation	NOUN
admet-535	215	13	of	of	ADP
admet-535	215	14	drug	drug	NOUN
admet-535	215	15	discovery	discovery	NOUN
admet-535	215	16	tools	tool	NOUN
admet-535	215	17	in	in	ADP
admet-535	215	18	phytochemistry	phytochemistry	NOUN
admet-535	215	19	and	and	CCONJ
admet-535	215	20	pharmacology	pharmacology	NOUN
admet-535	215	21	labs	lab	NOUN
admet-535	215	22	.	.	PUNCT
admet-535	216	1	these	these	DET
admet-535	216	2	columns	column	NOUN
admet-535	216	3	may	may	AUX
admet-535	216	4	be	be	AUX
admet-535	216	5	easily	easily	ADV
admet-535	216	6	applied	apply	VERB
admet-535	216	7	to	to	PART
admet-535	216	8	build	build	VERB
admet-535	216	9	libraries	library	NOUN
admet-535	216	10	of	of	ADP
admet-535	216	11	natural	natural	ADJ
admet-535	216	12	compounds	compound	NOUN
admet-535	216	13	that	that	PRON
admet-535	216	14	can	can	AUX
admet-535	216	15	move	move	VERB
admet-535	216	16	drug	drug	NOUN
admet-535	216	17	discovery	discovery	NOUN
admet-535	216	18	projects	project	NOUN
admet-535	216	19	forward	forward	ADV
admet-535	216	20	to	to	ADP
admet-535	216	21	the	the	DET
admet-535	216	22	next	next	ADJ
admet-535	216	23	step	step	NOUN
admet-535	216	24	.	.	PUNCT
admet-535	217	1	some	some	DET
admet-535	217	2	advice	advice	NOUN
admet-535	217	3	is	be	AUX
admet-535	217	4	given	give	VERB
admet-535	217	5	:	:	PUNCT
admet-535	217	6	carefully	carefully	ADV
admet-535	217	7	choose	choose	VERB
admet-535	217	8	your	your	PRON
admet-535	217	9	transmembrane	transmembrane	NOUN
admet-535	217	10	target	target	NOUN
admet-535	217	11	by	by	ADP
admet-535	217	12	closely	closely	ADV
admet-535	217	13	studying	study	VERB
admet-535	217	14	the	the	DET
admet-535	217	15	possible	possible	ADJ
admet-535	217	16	pathways	pathway	NOUN
admet-535	217	17	involved	involve	VERB
admet-535	217	18	in	in	ADP
admet-535	217	19	the	the	DET
admet-535	217	20	disease	disease	NOUN
admet-535	217	21	.	.	PUNCT
admet-535	218	1	an	an	DET
admet-535	218	2	example	example	NOUN
admet-535	218	3	is	be	AUX
admet-535	218	4	given	give	VERB
admet-535	218	5	from	from	ADP
admet-535	218	6	our	our	PRON
admet-535	218	7	lab	lab	NOUN
admet-535	218	8	:	:	PUNCT
admet-535	218	9	we	we	PRON
admet-535	218	10	are	be	AUX
admet-535	218	11	interested	interested	ADJ
admet-535	218	12	in	in	ADP
admet-535	218	13	cellular	cellular	ADJ
admet-535	218	14	signalling	signal	VERB
admet-535	218	15	pathways	pathway	NOUN
admet-535	218	16	that	that	PRON
admet-535	218	17	have	have	AUX
admet-535	218	18	evolved	evolve	VERB
admet-535	218	19	to	to	PART
admet-535	218	20	protect	protect	VERB
admet-535	218	21	neurons	neuron	NOUN
admet-535	218	22	from	from	ADP
admet-535	218	23	different	different	ADJ
admet-535	218	24	forms	form	NOUN
admet-535	218	25	of	of	ADP
admet-535	218	26	biological	biological	ADJ
admet-535	218	27	stress	stress	NOUN
admet-535	218	28	(	(	PUNCT
admet-535	218	29	oxidative	oxidative	ADJ
admet-535	218	30	,	,	PUNCT
admet-535	218	31	metabolic	metabolic	NOUN
admet-535	218	32	,	,	PUNCT
admet-535	218	33	proteotoxic	proteotoxic	ADJ
admet-535	218	34	or	or	CCONJ
admet-535	218	35	admet	admet	PROPN
admet-535	218	36	&	&	CCONJ
admet-535	218	37	dmpk	dmpk	PROPN
admet-535	218	38	6(3	6(3	PROPN
admet-535	218	39	)	)	PUNCT
admet-535	218	40	(	(	PUNCT
admet-535	218	41	2018	2018	NUM
admet-535	218	42	)	)	PUNCT
admet-535	218	43	200	200	NUM
admet-535	218	44	-	-	SYM
admet-535	218	45	214	214	NUM
admet-535	218	46	cell	cell	NOUN
admet-535	218	47	membrane	membrane	NOUN
admet-535	218	48	affinity	affinity	NOUN
admet-535	218	49	chromatography	chromatography	NOUN
admet-535	218	50	in	in	ADP
admet-535	218	51	drug	drug	NOUN
admet-535	218	52	discovery	discovery	NOUN
admet-535	218	53	doi	doi	PROPN
admet-535	218	54	:	:	PUNCT
admet-535	218	55	10.5599	10.5599	NUM
admet-535	218	56	/	/	SYM
admet-535	218	57	admet.535	admet.535	PROPN
admet-535	218	58	211	211	NUM
admet-535	218	59	inflammatory	inflammatory	ADJ
admet-535	218	60	stress	stress	NOUN
admet-535	218	61	)	)	PUNCT
admet-535	218	62	.	.	PUNCT
admet-535	219	1	published	publish	VERB
admet-535	219	2	data	datum	NOUN
admet-535	219	3	indicated	indicate	VERB
admet-535	219	4	that	that	SCONJ
admet-535	219	5	the	the	DET
admet-535	219	6	activation	activation	NOUN
admet-535	219	7	of	of	ADP
admet-535	219	8	the	the	DET
admet-535	219	9	bdnf	bdnf	ADJ
admet-535	219	10	(	(	PUNCT
admet-535	219	11	brain	brain	NOUN
admet-535	219	12	-	-	PUNCT
admet-535	219	13	derived	derive	VERB
admet-535	219	14	neurotrophic	neurotrophic	ADJ
admet-535	219	15	factor	factor	NOUN
admet-535	219	16	)	)	PUNCT
admet-535	219	17	pathway	pathway	NOUN
admet-535	219	18	is	be	AUX
admet-535	219	19	neuroprotective	neuroprotective	ADJ
admet-535	219	20	[	[	X
admet-535	219	21	48	48	NUM
admet-535	219	22	]	]	PUNCT
admet-535	219	23	.	.	PUNCT
admet-535	220	1	bdnf	bdnf	PROPN
admet-535	220	2	works	work	VERB
admet-535	220	3	by	by	ADP
admet-535	220	4	binding	bind	VERB
admet-535	220	5	with	with	ADP
admet-535	220	6	transmembrane	transmembrane	ADJ
admet-535	220	7	tropomyosin	tropomyosin	PROPN
admet-535	220	8	receptor	receptor	PROPN
admet-535	220	9	kinase	kinase	PROPN
admet-535	220	10	(	(	PUNCT
admet-535	220	11	trkb	trkb	NOUN
admet-535	220	12	)	)	PUNCT
admet-535	220	13	.	.	PUNCT
admet-535	221	1	a	a	DET
admet-535	221	2	cmac	cmac	NOUN
admet-535	221	3	column	column	NOUN
admet-535	221	4	with	with	ADP
admet-535	221	5	the	the	DET
admet-535	221	6	immobilized	immobilized	ADJ
admet-535	221	7	trkb	trkb	NOUN
admet-535	221	8	receptors	receptor	NOUN
admet-535	221	9	is	be	AUX
admet-535	221	10	to	to	PART
admet-535	221	11	be	be	AUX
admet-535	221	12	used	use	VERB
admet-535	221	13	to	to	PART
admet-535	221	14	screen	screen	VERB
admet-535	221	15	selected	select	VERB
admet-535	221	16	plant	plant	NOUN
admet-535	221	17	extracts	extract	NOUN
admet-535	221	18	for	for	ADP
admet-535	221	19	natural	natural	ADJ
admet-535	221	20	compounds	compound	NOUN
admet-535	221	21	binding	bind	VERB
admet-535	221	22	to	to	ADP
admet-535	221	23	this	this	DET
admet-535	221	24	receptor	receptor	NOUN
admet-535	221	25	and	and	CCONJ
admet-535	221	26	mimicking	mimic	VERB
admet-535	221	27	the	the	DET
admet-535	221	28	neuroprotective	neuroprotective	ADJ
admet-535	221	29	effects	effect	NOUN
admet-535	221	30	of	of	ADP
admet-535	221	31	bdnf	bdnf	PROPN
admet-535	221	32	.	.	PUNCT
admet-535	222	1	preparation	preparation	NOUN
admet-535	222	2	of	of	ADP
admet-535	222	3	cmac	cmac	NOUN
admet-535	222	4	columns	column	NOUN
admet-535	222	5	appears	appear	VERB
admet-535	222	6	to	to	PART
admet-535	222	7	be	be	AUX
admet-535	222	8	considered	consider	VERB
admet-535	222	9	as	as	ADP
admet-535	222	10	a	a	DET
admet-535	222	11	complicated	complicated	ADJ
admet-535	222	12	approach	approach	NOUN
admet-535	222	13	and	and	CCONJ
admet-535	222	14	this	this	PRON
admet-535	222	15	may	may	AUX
admet-535	222	16	prevent	prevent	VERB
admet-535	222	17	it	it	PRON
admet-535	222	18	from	from	ADP
admet-535	222	19	common	common	ADJ
admet-535	222	20	use	use	NOUN
admet-535	222	21	in	in	ADP
admet-535	222	22	drug	drug	NOUN
admet-535	222	23	discovery	discovery	NOUN
admet-535	222	24	or	or	CCONJ
admet-535	222	25	phytochemistry	phytochemistry	NOUN
admet-535	222	26	laboratories	laboratory	NOUN
admet-535	222	27	.	.	PUNCT
admet-535	223	1	the	the	DET
admet-535	223	2	truth	truth	NOUN
admet-535	223	3	is	be	AUX
admet-535	223	4	,	,	PUNCT
admet-535	223	5	the	the	DET
admet-535	223	6	preparation	preparation	NOUN
admet-535	223	7	of	of	ADP
admet-535	223	8	cmac	cmac	NOUN
admet-535	223	9	columns	column	NOUN
admet-535	223	10	is	be	AUX
admet-535	223	11	possible	possible	ADJ
admet-535	223	12	in	in	ADP
admet-535	223	13	almost	almost	ADV
admet-535	223	14	every	every	PRON
admet-535	223	15	lab	lab	NOUN
admet-535	223	16	focusing	focus	VERB
admet-535	223	17	on	on	ADP
admet-535	223	18	natural	natural	ADJ
admet-535	223	19	product	product	NOUN
admet-535	223	20	discovery	discovery	NOUN
admet-535	223	21	.	.	PUNCT
admet-535	224	1	future	future	ADJ
admet-535	224	2	direction	direction	NOUN
admet-535	224	3	may	may	AUX
admet-535	224	4	include	include	VERB
admet-535	224	5	the	the	DET
admet-535	224	6	development	development	NOUN
admet-535	224	7	of	of	ADP
admet-535	224	8	a	a	DET
admet-535	224	9	kit	kit	NOUN
admet-535	224	10	that	that	PRON
admet-535	224	11	would	would	AUX
admet-535	224	12	allow	allow	VERB
admet-535	224	13	interested	interested	ADJ
admet-535	224	14	labs	lab	NOUN
admet-535	224	15	to	to	PART
admet-535	224	16	easily	easily	ADV
admet-535	224	17	develop	develop	VERB
admet-535	224	18	a	a	DET
admet-535	224	19	column	column	NOUN
admet-535	224	20	with	with	ADP
admet-535	224	21	the	the	DET
admet-535	224	22	immobilized	immobilized	ADJ
admet-535	224	23	desired	desire	VERB
admet-535	224	24	transmembrane	transmembrane	ADJ
admet-535	224	25	protein	protein	NOUN
admet-535	224	26	.	.	PUNCT
admet-535	225	1	cmac	cmac	NOUN
admet-535	225	2	has	have	VERB
admet-535	225	3	a	a	DET
admet-535	225	4	potential	potential	NOUN
admet-535	225	5	to	to	PART
admet-535	225	6	work	work	VERB
admet-535	225	7	well	well	ADV
admet-535	225	8	with	with	ADP
admet-535	225	9	other	other	ADJ
admet-535	225	10	drug	drug	NOUN
admet-535	225	11	discovery	discovery	NOUN
admet-535	225	12	approaches	approach	NOUN
admet-535	225	13	,	,	PUNCT
admet-535	225	14	for	for	ADP
admet-535	225	15	example	example	NOUN
admet-535	225	16	,	,	PUNCT
admet-535	225	17	ligand	ligand	ADJ
admet-535	225	18	fishing	fishing	NOUN
admet-535	225	19	techniques	technique	NOUN
admet-535	225	20	.	.	PUNCT
admet-535	226	1	pharmacologically	pharmacologically	ADV
admet-535	226	2	active	active	ADJ
admet-535	226	3	compounds	compound	NOUN
admet-535	226	4	may	may	AUX
admet-535	226	5	be	be	AUX
admet-535	226	6	first	first	ADV
admet-535	226	7	identified	identify	VERB
admet-535	226	8	using	use	VERB
admet-535	226	9	ligand	ligand	NOUN
admet-535	226	10	fishing	fishing	NOUN
admet-535	226	11	techniques	technique	NOUN
admet-535	226	12	followed	follow	VERB
admet-535	226	13	by	by	ADP
admet-535	226	14	ligand	ligand	ADJ
admet-535	226	15	-	-	PUNCT
admet-535	226	16	protein	protein	NOUN
admet-535	226	17	interaction	interaction	NOUN
admet-535	226	18	studies	study	NOUN
admet-535	226	19	with	with	ADP
admet-535	226	20	a	a	DET
admet-535	226	21	cmac	cmac	NOUN
admet-535	226	22	column	column	NOUN
admet-535	226	23	.	.	PUNCT
admet-535	227	1	the	the	DET
admet-535	227	2	advent	advent	NOUN
admet-535	227	3	of	of	ADP
admet-535	227	4	novel	novel	ADJ
admet-535	227	5	drug	drug	NOUN
admet-535	227	6	discovery	discovery	NOUN
admet-535	227	7	approaches	approach	NOUN
admet-535	227	8	is	be	AUX
admet-535	227	9	needed	need	VERB
admet-535	227	10	in	in	ADP
admet-535	227	11	this	this	DET
admet-535	227	12	new	new	ADJ
admet-535	227	13	era	era	NOUN
admet-535	227	14	when	when	SCONJ
admet-535	227	15	drug	drug	NOUN
admet-535	227	16	discovery	discovery	NOUN
admet-535	227	17	from	from	ADP
admet-535	227	18	natural	natural	ADJ
admet-535	227	19	samples	sample	NOUN
admet-535	227	20	is	be	AUX
admet-535	227	21	again	again	ADV
admet-535	227	22	becoming	become	VERB
admet-535	227	23	popular	popular	ADJ
admet-535	227	24	.	.	PUNCT
admet-535	228	1	the	the	DET
admet-535	228	2	use	use	NOUN
admet-535	228	3	of	of	ADP
admet-535	228	4	old	old	ADJ
admet-535	228	5	techniques	technique	NOUN
admet-535	228	6	,	,	PUNCT
admet-535	228	7	that	that	PRON
admet-535	228	8	were	be	AUX
admet-535	228	9	one	one	NUM
admet-535	228	10	of	of	ADP
admet-535	228	11	the	the	DET
admet-535	228	12	reasons	reason	NOUN
admet-535	228	13	for	for	ADP
admet-535	228	14	abandoning	abandon	VERB
admet-535	228	15	natural	natural	ADJ
admet-535	228	16	product	product	NOUN
admet-535	228	17	screening	screening	NOUN
admet-535	228	18	,	,	PUNCT
admet-535	228	19	need	need	VERB
admet-535	228	20	to	to	PART
admet-535	228	21	be	be	AUX
admet-535	228	22	replaced	replace	VERB
admet-535	228	23	by	by	ADP
admet-535	228	24	innovative	innovative	ADJ
admet-535	228	25	assays	assay	NOUN
admet-535	228	26	.	.	PUNCT
admet-535	229	1	cellular	cellular	ADJ
admet-535	229	2	membrane	membrane	NOUN
admet-535	229	3	affinity	affinity	NOUN
admet-535	229	4	chromatography	chromatography	NOUN
admet-535	229	5	together	together	ADV
admet-535	229	6	with	with	ADP
admet-535	229	7	ligand	ligand	ADJ
admet-535	229	8	fishing	fishing	NOUN
admet-535	229	9	techniques	technique	NOUN
admet-535	229	10	have	have	VERB
admet-535	229	11	everything	everything	PRON
admet-535	229	12	that	that	PRON
admet-535	229	13	is	be	AUX
admet-535	229	14	required	require	VERB
admet-535	229	15	to	to	PART
admet-535	229	16	become	become	VERB
admet-535	229	17	drug	drug	NOUN
admet-535	229	18	discovery	discovery	NOUN
admet-535	229	19	techniques	technique	NOUN
admet-535	229	20	of	of	ADP
admet-535	229	21	the	the	DET
admet-535	229	22	21st	21st	ADJ
admet-535	229	23	century	century	NOUN
admet-535	229	24	.	.	PUNCT
admet-535	230	1	references	reference	NOUN
admet-535	230	2	[	[	X
admet-535	230	3	1	1	NUM
admet-535	230	4	]	]	X
admet-535	230	5	m.p	m.p	PROPN
admet-535	230	6	.	.	PROPN
admet-535	230	7	mattson	mattson	PROPN
admet-535	230	8	.	.	PUNCT
admet-535	231	1	what	what	PRON
admet-535	231	2	does	do	AUX
admet-535	231	3	n't	not	PART
admet-535	231	4	kill	kill	VERB
admet-535	231	5	you	you	PRON
admet-535	231	6	.	.	PUNCT
admet-535	232	1	sci	sci	PROPN
admet-535	232	2	am	be	AUX
admet-535	232	3	313	313	NUM
admet-535	232	4	(	(	PUNCT
admet-535	232	5	2015	2015	NUM
admet-535	232	6	)	)	PUNCT
admet-535	232	7	40	40	NUM
admet-535	232	8	-	-	SYM
admet-535	232	9	45	45	NUM
admet-535	232	10	.	.	PUNCT
admet-535	233	1	[	[	X
admet-535	233	2	2	2	NUM
admet-535	233	3	]	]	X
admet-535	233	4	m.p	m.p	PROPN
admet-535	233	5	.	.	PROPN
admet-535	233	6	mattson	mattson	PROPN
admet-535	233	7	,	,	PUNCT
admet-535	233	8	a.	a.	PROPN
admet-535	233	9	cheng	cheng	PROPN
admet-535	233	10	.	.	PUNCT
admet-535	234	1	neurohormetic	neurohormetic	ADJ
admet-535	234	2	phytochemicals	phytochemical	NOUN
admet-535	234	3	:	:	PUNCT
admet-535	234	4	low	low	ADJ
admet-535	234	5	-	-	PUNCT
admet-535	234	6	dose	dose	NOUN
admet-535	234	7	toxins	toxin	NOUN
admet-535	234	8	that	that	PRON
admet-535	234	9	induce	induce	VERB
admet-535	234	10	adaptive	adaptive	ADJ
admet-535	234	11	neuronal	neuronal	ADJ
admet-535	234	12	stress	stress	NOUN
admet-535	234	13	responses	response	NOUN
admet-535	234	14	.	.	PUNCT
admet-535	235	1	trends	trend	NOUN
admet-535	235	2	neurosci	neurosci	VERB
admet-535	235	3	29	29	NUM
admet-535	235	4	(	(	PUNCT
admet-535	235	5	2006	2006	NUM
admet-535	235	6	)	)	PUNCT
admet-535	235	7	632	632	NUM
admet-535	235	8	-	-	SYM
admet-535	235	9	639	639	NUM
admet-535	235	10	.	.	PUNCT
admet-535	236	1	[	[	X
admet-535	236	2	3	3	X
admet-535	236	3	]	]	X
admet-535	236	4	m.p	m.p	PROPN
admet-535	236	5	.	.	PROPN
admet-535	236	6	mattson	mattson	PROPN
admet-535	236	7	,	,	PUNCT
admet-535	236	8	t.g	t.g	PROPN
admet-535	236	9	.	.	PROPN
admet-535	236	10	son	son	PROPN
admet-535	236	11	,	,	PUNCT
admet-535	236	12	s.	s.	PROPN
admet-535	236	13	camandola	camandola	PROPN
admet-535	236	14	.	.	PUNCT
admet-535	237	1	viewpoint	viewpoint	NOUN
admet-535	237	2	:	:	PUNCT
admet-535	238	1	mechanisms	mechanism	NOUN
admet-535	238	2	of	of	ADP
admet-535	238	3	action	action	NOUN
admet-535	238	4	and	and	CCONJ
admet-535	238	5	therapeutic	therapeutic	ADJ
admet-535	238	6	potential	potential	NOUN
admet-535	238	7	of	of	ADP
admet-535	238	8	neurohormetic	neurohormetic	ADJ
admet-535	238	9	phytochemicals	phytochemical	NOUN
admet-535	238	10	.	.	PUNCT
admet-535	239	1	dose	dose	VERB
admet-535	239	2	response	response	NOUN
admet-535	239	3	5	5	NUM
admet-535	239	4	(	(	PUNCT
admet-535	239	5	2007	2007	NUM
admet-535	239	6	)	)	PUNCT
admet-535	239	7	174	174	NUM
admet-535	239	8	-	-	SYM
admet-535	239	9	186	186	NUM
admet-535	239	10	.	.	PUNCT
admet-535	240	1	[	[	X
admet-535	240	2	4	4	X
admet-535	240	3	]	]	PUNCT
admet-535	240	4	v.	v.	ADP
admet-535	240	5	murugaiyah	murugaiyah	PROPN
admet-535	240	6	,	,	PUNCT
admet-535	240	7	m.p	m.p	PROPN
admet-535	240	8	.	.	PROPN
admet-535	240	9	mattson	mattson	PROPN
admet-535	240	10	.	.	PUNCT
admet-535	241	1	neurohormetic	neurohormetic	ADJ
admet-535	241	2	phytochemicals	phytochemical	NOUN
admet-535	241	3	:	:	PUNCT
admet-535	241	4	an	an	DET
admet-535	241	5	evolutionary	evolutionary	ADJ
admet-535	241	6	-	-	PUNCT
admet-535	241	7	bioenergetic	bioenergetic	NOUN
admet-535	241	8	perspective	perspective	NOUN
admet-535	241	9	.	.	PUNCT
admet-535	242	1	neurochem	neurochem	PROPN
admet-535	242	2	int	int	PROPN
admet-535	242	3	89	89	NUM
admet-535	242	4	(	(	PUNCT
admet-535	242	5	2015	2015	NUM
admet-535	242	6	)	)	PUNCT
admet-535	242	7	271	271	NUM
admet-535	242	8	-	-	SYM
admet-535	242	9	280	280	NUM
admet-535	242	10	.	.	PUNCT
admet-535	243	1	[	[	X
admet-535	243	2	5	5	X
admet-535	243	3	]	]	PUNCT
admet-535	243	4	j.	j.	PROPN
admet-535	243	5	lee	lee	PROPN
admet-535	243	6	,	,	PUNCT
admet-535	243	7	d.g	d.g	PROPN
admet-535	243	8	.	.	PROPN
admet-535	243	9	jo	jo	PROPN
admet-535	243	10	,	,	PUNCT
admet-535	243	11	d.	d.	PROPN
admet-535	243	12	park	park	PROPN
admet-535	243	13	,	,	PUNCT
admet-535	243	14	h.y	h.y	PROPN
admet-535	243	15	.	.	PROPN
admet-535	243	16	chung	chung	PROPN
admet-535	243	17	,	,	PUNCT
admet-535	243	18	m.p	m.p	PROPN
admet-535	243	19	.	.	PROPN
admet-535	243	20	mattson	mattson	PROPN
admet-535	243	21	.	.	PUNCT
admet-535	244	1	adaptive	adaptive	ADJ
admet-535	244	2	cellular	cellular	ADJ
admet-535	244	3	stress	stress	NOUN
admet-535	244	4	pathways	pathway	NOUN
admet-535	244	5	as	as	ADP
admet-535	244	6	therapeutic	therapeutic	ADJ
admet-535	244	7	targets	target	NOUN
admet-535	244	8	of	of	ADP
admet-535	244	9	dietary	dietary	ADJ
admet-535	244	10	phytochemicals	phytochemical	NOUN
admet-535	244	11	:	:	PUNCT
admet-535	244	12	focus	focus	VERB
admet-535	244	13	on	on	ADP
admet-535	244	14	the	the	DET
admet-535	244	15	nervous	nervous	ADJ
admet-535	244	16	system	system	NOUN
admet-535	244	17	.	.	PUNCT
admet-535	245	1	pharmacol	pharmacol	PROPN
admet-535	245	2	rev	rev	VERB
admet-535	245	3	66	66	NUM
admet-535	245	4	(	(	PUNCT
admet-535	245	5	2014	2014	NUM
admet-535	245	6	)	)	PUNCT
admet-535	245	7	815	815	NUM
admet-535	245	8	-	-	SYM
admet-535	245	9	868	868	NUM
admet-535	245	10	.	.	PUNCT
admet-535	246	1	[	[	X
admet-535	246	2	6	6	NUM
admet-535	246	3	]	]	PUNCT
admet-535	246	4	b.	b.	PROPN
admet-535	246	5	shen	shen	PROPN
admet-535	246	6	.	.	PUNCT
admet-535	247	1	a	a	DET
admet-535	247	2	new	new	ADJ
admet-535	247	3	golden	golden	ADJ
admet-535	247	4	age	age	NOUN
admet-535	247	5	of	of	ADP
admet-535	247	6	natural	natural	ADJ
admet-535	247	7	products	product	NOUN
admet-535	247	8	drug	drug	NOUN
admet-535	247	9	discovery	discovery	NOUN
admet-535	247	10	.	.	PUNCT
admet-535	248	1	cell	cell	NOUN
admet-535	248	2	163	163	NUM
admet-535	248	3	(	(	PUNCT
admet-535	248	4	2015	2015	NUM
admet-535	248	5	)	)	PUNCT
admet-535	248	6	1297	1297	NUM
admet-535	248	7	-	-	SYM
admet-535	248	8	1300	1300	NUM
admet-535	248	9	.	.	PUNCT
admet-535	249	1	[	[	X
admet-535	249	2	7	7	X
admet-535	249	3	]	]	X
admet-535	249	4	l.	l.	PROPN
admet-535	249	5	ciesla	ciesla	PROPN
admet-535	249	6	,	,	PUNCT
admet-535	249	7	r.	r.	PROPN
admet-535	249	8	moaddel	moaddel	PROPN
admet-535	249	9	.	.	PUNCT
admet-535	250	1	comparison	comparison	NOUN
admet-535	250	2	of	of	ADP
admet-535	250	3	analytical	analytical	ADJ
admet-535	250	4	techniques	technique	NOUN
admet-535	250	5	for	for	ADP
admet-535	250	6	the	the	DET
admet-535	250	7	identification	identification	NOUN
admet-535	250	8	of	of	ADP
admet-535	250	9	bioactive	bioactive	ADJ
admet-535	250	10	compounds	compound	NOUN
admet-535	250	11	from	from	ADP
admet-535	250	12	natural	natural	ADJ
admet-535	250	13	products	product	NOUN
admet-535	250	14	.	.	PUNCT
admet-535	251	1	nat	nat	PROPN
admet-535	251	2	prod	prod	PROPN
admet-535	251	3	rep	rep	PROPN
admet-535	251	4	33	33	NUM
admet-535	251	5	(	(	PUNCT
admet-535	251	6	2016	2016	NUM
admet-535	251	7	)	)	PUNCT
admet-535	251	8	1131	1131	NUM
admet-535	251	9	-	-	SYM
admet-535	251	10	1145	1145	NUM
admet-535	251	11	.	.	PUNCT
admet-535	252	1	[	[	X
admet-535	252	2	8	8	NUM
admet-535	252	3	]	]	X
admet-535	252	4	a.l	a.l	PROPN
admet-535	252	5	.	.	PROPN
admet-535	252	6	harvey	harvey	PROPN
admet-535	252	7	,	,	PUNCT
admet-535	252	8	r.	r.	PROPN
admet-535	252	9	edrada	edrada	PROPN
admet-535	252	10	-	-	PUNCT
admet-535	252	11	ebel	ebel	PROPN
admet-535	252	12	,	,	PUNCT
admet-535	252	13	r.j	r.j	PROPN
admet-535	252	14	.	.	PROPN
admet-535	252	15	quinn	quinn	PROPN
admet-535	252	16	.	.	PUNCT
admet-535	253	1	the	the	DET
admet-535	253	2	re	re	NOUN
admet-535	253	3	-	-	NOUN
admet-535	253	4	emergence	emergence	NOUN
admet-535	253	5	of	of	ADP
admet-535	253	6	natural	natural	ADJ
admet-535	253	7	products	product	NOUN
admet-535	253	8	for	for	ADP
admet-535	253	9	drug	drug	NOUN
admet-535	253	10	discovery	discovery	NOUN
admet-535	253	11	in	in	ADP
admet-535	253	12	the	the	DET
admet-535	253	13	genomics	genomics	NOUN
admet-535	253	14	era	era	NOUN
admet-535	253	15	.	.	PUNCT
admet-535	254	1	nat	nat	PROPN
admet-535	254	2	rev	rev	PROPN
admet-535	254	3	drug	drug	PROPN
admet-535	254	4	discov	discov	PROPN
admet-535	254	5	14	14	NUM
admet-535	254	6	(	(	PUNCT
admet-535	254	7	2015	2015	NUM
admet-535	254	8	)	)	PUNCT
admet-535	254	9	111	111	NUM
admet-535	254	10	-	-	SYM
admet-535	254	11	129	129	NUM
admet-535	254	12	.	.	PUNCT
admet-535	255	1	[	[	X
admet-535	255	2	9	9	NUM
admet-535	255	3	]	]	PUNCT
admet-535	255	4	m.	m.	NOUN
admet-535	255	5	yasuda	yasuda	PROPN
admet-535	255	6	,	,	PUNCT
admet-535	255	7	d.r	d.r	PROPN
admet-535	255	8	.	.	PROPN
admet-535	255	9	wilson	wilson	PROPN
admet-535	255	10	,	,	PUNCT
admet-535	255	11	s.d	s.d	PROPN
admet-535	255	12	.	.	PROPN
admet-535	255	13	fugmann	fugmann	PROPN
admet-535	255	14	,	,	PUNCT
admet-535	255	15	r.	r.	PROPN
admet-535	255	16	moaddel	moaddel	PROPN
admet-535	255	17	.	.	PUNCT
admet-535	256	1	synthesis	synthesis	NOUN
admet-535	256	2	and	and	CCONJ
admet-535	256	3	characterization	characterization	NOUN
admet-535	256	4	of	of	ADP
admet-535	256	5	sirt6	sirt6	NOUN
admet-535	256	6	protein	protein	NOUN
admet-535	256	7	coated	coat	VERB
admet-535	256	8	magnetic	magnetic	ADJ
admet-535	256	9	beads	bead	NOUN
admet-535	256	10	:	:	PUNCT
admet-535	256	11	identification	identification	NOUN
admet-535	256	12	of	of	ADP
admet-535	256	13	a	a	DET
admet-535	256	14	novel	novel	ADJ
admet-535	256	15	inhibitor	inhibitor	NOUN
admet-535	256	16	of	of	ADP
admet-535	256	17	sirt6	sirt6	NOUN
admet-535	256	18	deacetylase	deacetylase	NOUN
admet-535	256	19	from	from	ADP
admet-535	256	20	medicinal	medicinal	ADJ
admet-535	256	21	plant	plant	NOUN
admet-535	256	22	extracts	extract	NOUN
admet-535	256	23	.	.	PUNCT
admet-535	257	1	anal	anal	ADJ
admet-535	257	2	chem	chem	NOUN
admet-535	257	3	83	83	NUM
admet-535	257	4	(	(	PUNCT
admet-535	257	5	2011	2011	NUM
admet-535	257	6	)	)	PUNCT
admet-535	257	7	7400	7400	NUM
admet-535	257	8	-	-	SYM
admet-535	257	9	7407	7407	NUM
admet-535	257	10	.	.	PUNCT
admet-535	258	1	[	[	X
admet-535	258	2	10	10	NUM
admet-535	258	3	]	]	X
admet-535	258	4	n.	n.	PROPN
admet-535	258	5	singh	singh	PROPN
admet-535	258	6	,	,	PUNCT
admet-535	258	7	s.	s.	PROPN
admet-535	258	8	ravichandran	ravichandran	PROPN
admet-535	258	9	,	,	PUNCT
admet-535	258	10	d.d	d.d	PROPN
admet-535	258	11	.	.	PROPN
admet-535	258	12	norton	norton	PROPN
admet-535	258	13	,	,	PUNCT
admet-535	258	14	s.d	s.d	PROPN
admet-535	258	15	.	.	PROPN
admet-535	258	16	fugmann	fugmann	PROPN
admet-535	258	17	,	,	PUNCT
admet-535	258	18	r.	r.	PROPN
admet-535	258	19	moaddel	moaddel	PROPN
admet-535	258	20	.	.	PUNCT
admet-535	259	1	synthesis	synthesis	NOUN
admet-535	259	2	and	and	CCONJ
admet-535	259	3	characterization	characterization	NOUN
admet-535	259	4	of	of	ADP
admet-535	259	5	a	a	DET
admet-535	259	6	sirt6	sirt6	NOUN
admet-535	259	7	open	open	ADJ
admet-535	259	8	tubular	tubular	ADJ
admet-535	259	9	column	column	NOUN
admet-535	259	10	:	:	PUNCT
admet-535	259	11	predicting	predict	VERB
admet-535	259	12	deacetylation	deacetylation	NOUN
admet-535	259	13	activity	activity	NOUN
admet-535	259	14	using	use	VERB
admet-535	259	15	frontal	frontal	ADJ
admet-535	259	16	chromatography	chromatography	NOUN
admet-535	259	17	.	.	PUNCT
admet-535	260	1	anal	anal	ADJ
admet-535	260	2	biochem	biochem	NOUN
admet-535	260	3	436	436	NUM
admet-535	260	4	(	(	PUNCT
admet-535	260	5	2013	2013	NUM
admet-535	260	6	)	)	PUNCT
admet-535	260	7	78	78	NUM
admet-535	260	8	-	-	SYM
admet-535	260	9	83	83	NUM
admet-535	260	10	.	.	PUNCT
admet-535	261	1	[	[	X
admet-535	261	2	11	11	NUM
admet-535	261	3	]	]	X
admet-535	261	4	r.	r.	PROPN
admet-535	261	5	moaddel	moaddel	PROPN
admet-535	261	6	,	,	PUNCT
admet-535	261	7	i.w	i.w	PROPN
admet-535	261	8	.	.	PROPN
admet-535	261	9	wainer	wainer	PROPN
admet-535	261	10	.	.	PUNCT
admet-535	262	1	the	the	DET
admet-535	262	2	preparation	preparation	NOUN
admet-535	262	3	and	and	CCONJ
admet-535	262	4	development	development	NOUN
admet-535	262	5	of	of	ADP
admet-535	262	6	cellular	cellular	ADJ
admet-535	262	7	membrane	membrane	NOUN
admet-535	262	8	affinity	affinity	NOUN
admet-535	262	9	chromatography	chromatography	NOUN
admet-535	262	10	columns	column	NOUN
admet-535	262	11	.	.	PUNCT
admet-535	263	1	nat	nat	PROPN
admet-535	263	2	protoc	protoc	VERB
admet-535	263	3	4	4	NUM
admet-535	263	4	(	(	PUNCT
admet-535	263	5	2009	2009	NUM
admet-535	263	6	)	)	PUNCT
admet-535	263	7	197	197	NUM
admet-535	263	8	-	-	SYM
admet-535	263	9	205	205	NUM
admet-535	263	10	.	.	PUNCT
admet-535	264	1	[	[	X
admet-535	264	2	12	12	NUM
admet-535	264	3	]	]	X
admet-535	264	4	e.	e.	PROPN
admet-535	264	5	brekkan	brekkan	PROPN
admet-535	264	6	,	,	PUNCT
admet-535	264	7	a.	a.	PROPN
admet-535	264	8	lundqvist	lundqvist	PROPN
admet-535	264	9	,	,	PUNCT
admet-535	264	10	p.	p.	PROPN
admet-535	264	11	lundahl	lundahl	PROPN
admet-535	264	12	.	.	PUNCT
admet-535	265	1	immobilized	immobilized	ADJ
admet-535	265	2	membrane	membrane	NOUN
admet-535	265	3	vesicle	vesicle	NOUN
admet-535	265	4	or	or	CCONJ
admet-535	265	5	proteoliposome	proteoliposome	NOUN
admet-535	265	6	affinity	affinity	NOUN
admet-535	265	7	chromatography	chromatography	NOUN
admet-535	265	8	.	.	PUNCT
admet-535	266	1	frontal	frontal	ADJ
admet-535	266	2	analysis	analysis	NOUN
admet-535	266	3	of	of	ADP
admet-535	266	4	interactions	interaction	NOUN
admet-535	266	5	of	of	ADP
admet-535	266	6	cytochalasin	cytochalasin	PROPN
admet-535	266	7	b	b	PROPN
admet-535	266	8	and	and	CCONJ
admet-535	266	9	d	d	NOUN
admet-535	266	10	-	-	PUNCT
admet-535	266	11	glucose	glucose	NOUN
admet-535	266	12	with	with	ADP
admet-535	266	13	the	the	DET
admet-535	266	14	human	human	ADJ
admet-535	266	15	red	red	ADJ
admet-535	266	16	cell	cell	NOUN
admet-535	266	17	glucose	glucose	NOUN
admet-535	266	18	transporter	transporter	NOUN
admet-535	266	19	.	.	PUNCT
admet-535	267	1	biochemistry	biochemistry	NOUN
admet-535	267	2	35	35	NUM
admet-535	267	3	(	(	PUNCT
admet-535	267	4	1996	1996	NUM
admet-535	267	5	)	)	PUNCT
admet-535	267	6	12141	12141	NUM
admet-535	267	7	-	-	SYM
admet-535	267	8	12145	12145	NUM
admet-535	267	9	.	.	PUNCT
admet-535	268	1	cayman	cayman	PROPN
admet-535	268	2	,	,	PUNCT
admet-535	268	3	omri	omri	PROPN
admet-535	268	4	&	&	CCONJ
admet-535	268	5	ciesla	ciesla	PROPN
admet-535	268	6	admet	admet	PROPN
admet-535	268	7	&	&	CCONJ
admet-535	268	8	dmpk	dmpk	PROPN
admet-535	268	9	6(3	6(3	PROPN
admet-535	268	10	)	)	PUNCT
admet-535	268	11	(	(	PUNCT
admet-535	268	12	2018	2018	NUM
admet-535	268	13	)	)	PUNCT
admet-535	268	14	200	200	NUM
admet-535	268	15	-	-	SYM
admet-535	268	16	214	214	NUM
admet-535	268	17	212	212	NUM
admet-535	268	18	[	[	SYM
admet-535	268	19	13	13	NUM
admet-535	268	20	]	]	X
admet-535	268	21	y.	y.	PROPN
admet-535	268	22	zhang	zhang	PROPN
admet-535	268	23	,	,	PUNCT
admet-535	268	24	y.	y.	PROPN
admet-535	268	25	xiao	xiao	PROPN
admet-535	268	26	,	,	PUNCT
admet-535	268	27	k.j	k.j	PROPN
admet-535	268	28	.	.	PUNCT
admet-535	268	29	kellar	kellar	PROPN
admet-535	268	30	,	,	PUNCT
admet-535	268	31	i.w	i.w	PROPN
admet-535	268	32	.	.	PROPN
admet-535	268	33	wainer	wainer	PROPN
admet-535	268	34	.	.	PUNCT
admet-535	269	1	immobilized	immobilized	ADJ
admet-535	269	2	nicotinic	nicotinic	ADJ
admet-535	269	3	receptor	receptor	NOUN
admet-535	269	4	stationary	stationary	ADJ
admet-535	269	5	phase	phase	NOUN
admet-535	269	6	for	for	ADP
admet-535	269	7	on	on	ADP
admet-535	269	8	-	-	PUNCT
admet-535	269	9	line	line	NOUN
admet-535	269	10	liquid	liquid	ADJ
admet-535	269	11	chromatographic	chromatographic	ADJ
admet-535	269	12	determination	determination	NOUN
admet-535	269	13	of	of	ADP
admet-535	269	14	drug	drug	NOUN
admet-535	269	15	-	-	PUNCT
admet-535	269	16	receptor	receptor	NOUN
admet-535	269	17	affinities	affinity	NOUN
admet-535	269	18	.	.	PUNCT
admet-535	270	1	anal	anal	ADJ
admet-535	270	2	biochem	biochem	NOUN
admet-535	270	3	264	264	NUM
admet-535	270	4	(	(	PUNCT
admet-535	270	5	1998	1998	NUM
admet-535	270	6	)	)	PUNCT
admet-535	270	7	22	22	NUM
admet-535	270	8	-	-	SYM
admet-535	270	9	25	25	NUM
admet-535	270	10	.	.	PUNCT
admet-535	271	1	[	[	X
admet-535	271	2	14	14	NUM
admet-535	271	3	]	]	X
admet-535	271	4	s.	s.	PROPN
admet-535	271	5	ong	ong	PROPN
admet-535	271	6	,	,	PUNCT
admet-535	271	7	h.	h.	PROPN
admet-535	271	8	liu	liu	PROPN
admet-535	271	9	,	,	PUNCT
admet-535	271	10	x.	x.	PROPN
admet-535	271	11	qiu	qiu	PROPN
admet-535	271	12	,	,	PUNCT
admet-535	271	13	g.	g.	PROPN
admet-535	271	14	bhat	bhat	PROPN
admet-535	271	15	,	,	PUNCT
admet-535	271	16	c.	c.	PROPN
admet-535	271	17	pidgeon	pidgeon	PROPN
admet-535	271	18	.	.	PUNCT
admet-535	272	1	membrane	membrane	NOUN
admet-535	272	2	partition	partition	NOUN
admet-535	272	3	coefficients	coefficient	NOUN
admet-535	272	4	chromatographically	chromatographically	ADV
admet-535	272	5	measured	measure	VERB
admet-535	272	6	using	use	VERB
admet-535	272	7	immobilized	immobilized	ADJ
admet-535	272	8	artificial	artificial	ADJ
admet-535	272	9	membrane	membrane	NOUN
admet-535	272	10	surfaces	surface	NOUN
admet-535	272	11	.	.	PUNCT
admet-535	273	1	anal	anal	ADJ
admet-535	273	2	chem	chem	NOUN
admet-535	273	3	67	67	NUM
admet-535	273	4	(	(	PUNCT
admet-535	273	5	1995	1995	NUM
admet-535	273	6	)	)	PUNCT
admet-535	273	7	755	755	NUM
admet-535	273	8	-	-	SYM
admet-535	273	9	762	762	NUM
admet-535	273	10	.	.	PUNCT
admet-535	274	1	[	[	X
admet-535	274	2	15	15	NUM
admet-535	274	3	]	]	X
admet-535	274	4	i.w	i.w	PROPN
admet-535	274	5	.	.	PROPN
admet-535	274	6	wainer	wainer	PROPN
admet-535	274	7	,	,	PUNCT
admet-535	274	8	y.	y.	PROPN
admet-535	274	9	zhang	zhang	PROPN
admet-535	274	10	,	,	PUNCT
admet-535	274	11	y.	y.	PROPN
admet-535	274	12	xiao	xiao	PROPN
admet-535	274	13	,	,	PUNCT
admet-535	274	14	k.j	k.j	PROPN
admet-535	274	15	.	.	PUNCT
admet-535	274	16	kellar	kellar	PROPN
admet-535	274	17	.	.	PUNCT
admet-535	275	1	liquid	liquid	ADJ
admet-535	275	2	chromatographic	chromatographic	ADJ
admet-535	275	3	studies	study	NOUN
admet-535	275	4	with	with	ADP
admet-535	275	5	immobilized	immobilized	ADJ
admet-535	275	6	neuronal	neuronal	ADJ
admet-535	275	7	nicotinic	nicotinic	ADJ
admet-535	275	8	acetylcholine	acetylcholine	NOUN
admet-535	275	9	receptor	receptor	NOUN
admet-535	275	10	stationary	stationary	ADJ
admet-535	275	11	phases	phase	NOUN
admet-535	275	12	:	:	PUNCT
admet-535	275	13	effects	effect	NOUN
admet-535	275	14	of	of	ADP
admet-535	275	15	receptor	receptor	NOUN
admet-535	275	16	subtypes	subtype	NOUN
admet-535	275	17	,	,	PUNCT
admet-535	275	18	ph	ph	ADJ
admet-535	275	19	and	and	CCONJ
admet-535	275	20	ionic	ionic	ADJ
admet-535	275	21	strength	strength	NOUN
admet-535	275	22	on	on	ADP
admet-535	275	23	drug	drug	NOUN
admet-535	275	24	-	-	PUNCT
admet-535	275	25	receptor	receptor	NOUN
admet-535	275	26	interactions	interaction	NOUN
admet-535	275	27	.	.	PUNCT
admet-535	276	1	j	j	PROPN
admet-535	276	2	chromatogr	chromatogr	PROPN
admet-535	276	3	b	b	PROPN
admet-535	276	4	biomed	biome	VERB
admet-535	276	5	sci	sci	PROPN
admet-535	276	6	appl	appl	PROPN
admet-535	276	7	724	724	NUM
admet-535	276	8	(	(	PUNCT
admet-535	276	9	1999	1999	NUM
admet-535	276	10	)	)	PUNCT
admet-535	276	11	65	65	NUM
admet-535	276	12	-	-	SYM
admet-535	276	13	72	72	NUM
admet-535	276	14	.	.	PUNCT
admet-535	277	1	[	[	X
admet-535	277	2	16	16	NUM
admet-535	277	3	]	]	X
admet-535	277	4	m.t	m.t	PROPN
admet-535	277	5	.	.	PROPN
admet-535	277	6	baynham	baynham	PROPN
admet-535	277	7	,	,	PUNCT
admet-535	277	8	s.	s.	PROPN
admet-535	277	9	patel	patel	PROPN
admet-535	277	10	,	,	PUNCT
admet-535	277	11	r.	r.	PROPN
admet-535	277	12	moaddel	moaddel	PROPN
admet-535	277	13	,	,	PUNCT
admet-535	277	14	i.w	i.w	PROPN
admet-535	277	15	.	.	PROPN
admet-535	277	16	wainer	wainer	PROPN
admet-535	277	17	.	.	PUNCT
admet-535	278	1	multidimensional	multidimensional	ADJ
admet-535	278	2	on	on	ADP
admet-535	278	3	-	-	PUNCT
admet-535	278	4	line	line	NOUN
admet-535	278	5	screening	screening	NOUN
admet-535	278	6	for	for	ADP
admet-535	278	7	ligands	ligand	NOUN
admet-535	278	8	to	to	ADP
admet-535	278	9	the	the	DET
admet-535	278	10	alpha3beta4	alpha3beta4	NOUN
admet-535	278	11	neuronal	neuronal	ADJ
admet-535	278	12	nicotinic	nicotinic	ADJ
admet-535	278	13	acetylcholine	acetylcholine	NOUN
admet-535	278	14	receptor	receptor	NOUN
admet-535	278	15	using	use	VERB
admet-535	278	16	an	an	DET
admet-535	278	17	immobilized	immobilized	ADJ
admet-535	278	18	nicotinic	nicotinic	ADJ
admet-535	278	19	receptor	receptor	NOUN
admet-535	278	20	liquid	liquid	ADJ
admet-535	278	21	chromatographic	chromatographic	ADJ
admet-535	278	22	stationary	stationary	ADJ
admet-535	278	23	phase	phase	NOUN
admet-535	278	24	.	.	PUNCT
admet-535	279	1	j	j	PROPN
admet-535	279	2	chromatogr	chromatogr	PROPN
admet-535	279	3	b	b	PROPN
admet-535	279	4	analyt	analyt	PROPN
admet-535	279	5	technol	technol	PROPN
admet-535	279	6	biomed	biome	VERB
admet-535	279	7	life	life	NOUN
admet-535	279	8	sci	sci	PROPN
admet-535	279	9	772	772	NUM
admet-535	279	10	(	(	PUNCT
admet-535	279	11	2002	2002	NUM
admet-535	279	12	)	)	PUNCT
admet-535	279	13	155	155	NUM
admet-535	279	14	-	-	SYM
admet-535	279	15	161	161	NUM
admet-535	279	16	.	.	PUNCT
admet-535	280	1	[	[	X
admet-535	280	2	17	17	NUM
admet-535	280	3	]	]	X
admet-535	280	4	k.	k.	PROPN
admet-535	280	5	jozwiak	jozwiak	PROPN
admet-535	280	6	,	,	PUNCT
admet-535	280	7	j.	j.	PROPN
admet-535	280	8	haginaka	haginaka	PROPN
admet-535	280	9	,	,	PUNCT
admet-535	280	10	r.	r.	PROPN
admet-535	280	11	moaddel	moaddel	PROPN
admet-535	280	12	,	,	PUNCT
admet-535	280	13	i.w	i.w	PROPN
admet-535	280	14	.	.	PROPN
admet-535	280	15	wainer	wainer	PROPN
admet-535	280	16	.	.	PUNCT
admet-535	281	1	displacement	displacement	NOUN
admet-535	281	2	and	and	CCONJ
admet-535	281	3	nonlinear	nonlinear	ADJ
admet-535	281	4	chromatographic	chromatographic	ADJ
admet-535	281	5	techniques	technique	NOUN
admet-535	281	6	in	in	ADP
admet-535	281	7	the	the	DET
admet-535	281	8	investigation	investigation	NOUN
admet-535	281	9	of	of	ADP
admet-535	281	10	interaction	interaction	NOUN
admet-535	281	11	of	of	ADP
admet-535	281	12	noncompetitive	noncompetitive	ADJ
admet-535	281	13	inhibitors	inhibitor	NOUN
admet-535	281	14	with	with	ADP
admet-535	281	15	an	an	DET
admet-535	281	16	immobilized	immobilized	ADJ
admet-535	281	17	alpha3beta4	alpha3beta4	NOUN
admet-535	281	18	nicotinic	nicotinic	ADJ
admet-535	281	19	acetylcholine	acetylcholine	NOUN
admet-535	281	20	receptor	receptor	NOUN
admet-535	281	21	liquid	liquid	VERB
admet-535	281	22	chromatographic	chromatographic	ADJ
admet-535	281	23	stationary	stationary	ADJ
admet-535	281	24	phase	phase	NOUN
admet-535	281	25	.	.	PUNCT
admet-535	282	1	anal	anal	ADJ
admet-535	282	2	chem	chem	NOUN
admet-535	282	3	74	74	NUM
admet-535	282	4	(	(	PUNCT
admet-535	282	5	2002	2002	NUM
admet-535	282	6	)	)	PUNCT
admet-535	282	7	4618	4618	NUM
admet-535	282	8	-	-	SYM
admet-535	282	9	4624	4624	NUM
admet-535	282	10	.	.	PUNCT
admet-535	283	1	[	[	X
admet-535	283	2	18	18	NUM
admet-535	283	3	]	]	X
admet-535	283	4	r.	r.	PROPN
admet-535	283	5	moaddel	moaddel	PROPN
admet-535	283	6	,	,	PUNCT
admet-535	283	7	i.w	i.w	PROPN
admet-535	283	8	.	.	PROPN
admet-535	283	9	wainer	wainer	PROPN
admet-535	283	10	.	.	PUNCT
admet-535	284	1	immobilized	immobilized	ADJ
admet-535	284	2	nicotinic	nicotinic	ADJ
admet-535	284	3	receptor	receptor	NOUN
admet-535	284	4	stationary	stationary	ADJ
admet-535	284	5	phases	phase	NOUN
admet-535	284	6	:	:	PUNCT
admet-535	284	7	going	go	VERB
admet-535	284	8	with	with	ADP
admet-535	284	9	the	the	DET
admet-535	284	10	flow	flow	NOUN
admet-535	284	11	in	in	ADP
admet-535	284	12	high	high	ADJ
admet-535	284	13	-	-	PUNCT
admet-535	284	14	throughput	throughput	NOUN
admet-535	284	15	screening	screening	NOUN
admet-535	284	16	and	and	CCONJ
admet-535	284	17	pharmacological	pharmacological	ADJ
admet-535	284	18	studies	study	NOUN
admet-535	284	19	.	.	PUNCT
admet-535	285	1	j	j	PROPN
admet-535	285	2	pharm	pharm	PROPN
admet-535	285	3	biomed	biome	VERB
admet-535	285	4	anal	anal	ADJ
admet-535	285	5	30	30	NUM
admet-535	285	6	(	(	PUNCT
admet-535	285	7	2003	2003	NUM
admet-535	285	8	)	)	PUNCT
admet-535	285	9	1715	1715	NUM
admet-535	285	10	-	-	SYM
admet-535	285	11	1724	1724	NUM
admet-535	285	12	.	.	PUNCT
admet-535	286	1	[	[	X
admet-535	286	2	19	19	NUM
admet-535	286	3	]	]	PUNCT
admet-535	286	4	k.	k.	PROPN
admet-535	286	5	jozwiak	jozwiak	PROPN
admet-535	286	6	,	,	PUNCT
admet-535	286	7	s.c	s.c	PROPN
admet-535	286	8	.	.	PROPN
admet-535	286	9	hernandez	hernandez	PROPN
admet-535	286	10	,	,	PUNCT
admet-535	286	11	k.j	k.j	PROPN
admet-535	286	12	.	.	PUNCT
admet-535	286	13	kellar	kellar	PROPN
admet-535	286	14	,	,	PUNCT
admet-535	286	15	i.w	i.w	PROPN
admet-535	286	16	.	.	PROPN
admet-535	286	17	wainer	wainer	PROPN
admet-535	286	18	.	.	PUNCT
admet-535	287	1	enantioselective	enantioselective	ADJ
admet-535	287	2	interactions	interaction	NOUN
admet-535	287	3	of	of	ADP
admet-535	287	4	dextromethorphan	dextromethorphan	NOUN
admet-535	287	5	and	and	CCONJ
admet-535	287	6	levomethorphan	levomethorphan	ADV
admet-535	287	7	with	with	ADP
admet-535	287	8	the	the	DET
admet-535	287	9	alpha	alpha	NOUN
admet-535	287	10	3	3	NUM
admet-535	287	11	beta	beta	NOUN
admet-535	287	12	4	4	NUM
admet-535	287	13	-	-	PUNCT
admet-535	287	14	nicotinic	nicotinic	ADJ
admet-535	287	15	acetylcholine	acetylcholine	NOUN
admet-535	287	16	receptor	receptor	NOUN
admet-535	287	17	:	:	PUNCT
admet-535	287	18	comparison	comparison	NOUN
admet-535	287	19	of	of	ADP
admet-535	287	20	chromatographic	chromatographic	ADJ
admet-535	287	21	and	and	CCONJ
admet-535	287	22	functional	functional	ADJ
admet-535	287	23	data	datum	NOUN
admet-535	287	24	.	.	PUNCT
admet-535	288	1	j	j	PROPN
admet-535	288	2	chromatogr	chromatogr	PROPN
admet-535	288	3	b	b	PROPN
admet-535	288	4	analyt	analyt	PROPN
admet-535	288	5	technol	technol	PROPN
admet-535	288	6	biomed	biome	VERB
admet-535	288	7	life	life	NOUN
admet-535	288	8	sci	sci	PROPN
admet-535	288	9	797	797	NUM
admet-535	288	10	(	(	PUNCT
admet-535	288	11	2003	2003	NUM
admet-535	288	12	)	)	PUNCT
admet-535	288	13	373	373	NUM
admet-535	288	14	-	-	SYM
admet-535	288	15	379	379	NUM
admet-535	288	16	.	.	PUNCT
admet-535	289	1	[	[	X
admet-535	289	2	20	20	NUM
admet-535	289	3	]	]	PUNCT
admet-535	289	4	k.	k.	PROPN
admet-535	289	5	jozwiak	jozwiak	PROPN
admet-535	289	6	,	,	PUNCT
admet-535	289	7	s.	s.	PROPN
admet-535	289	8	ravichandran	ravichandran	PROPN
admet-535	289	9	,	,	PUNCT
admet-535	289	10	j.r	j.r	PROPN
admet-535	289	11	.	.	PROPN
admet-535	289	12	collins	collins	PROPN
admet-535	289	13	,	,	PUNCT
admet-535	289	14	i.w	i.w	PROPN
admet-535	289	15	.	.	PROPN
admet-535	289	16	wainer	wainer	PROPN
admet-535	289	17	.	.	PUNCT
admet-535	290	1	interaction	interaction	NOUN
admet-535	290	2	of	of	ADP
admet-535	290	3	noncompetitive	noncompetitive	ADJ
admet-535	290	4	inhibitors	inhibitor	NOUN
admet-535	290	5	with	with	ADP
admet-535	290	6	an	an	DET
admet-535	290	7	immobilized	immobilized	ADJ
admet-535	290	8	alpha3beta4	alpha3beta4	NOUN
admet-535	290	9	nicotinic	nicotinic	ADJ
admet-535	290	10	acetylcholine	acetylcholine	NOUN
admet-535	290	11	receptor	receptor	NOUN
admet-535	290	12	investigated	investigate	VERB
admet-535	290	13	by	by	ADP
admet-535	290	14	affinity	affinity	NOUN
admet-535	290	15	chromatography	chromatography	NOUN
admet-535	290	16	,	,	PUNCT
admet-535	290	17	quantitative	quantitative	ADJ
admet-535	290	18	-	-	PUNCT
admet-535	290	19	structure	structure	NOUN
admet-535	290	20	activity	activity	NOUN
admet-535	290	21	relationship	relationship	NOUN
admet-535	290	22	analysis	analysis	NOUN
admet-535	290	23	,	,	PUNCT
admet-535	290	24	and	and	CCONJ
admet-535	290	25	molecular	molecular	ADJ
admet-535	290	26	docking	docking	NOUN
admet-535	290	27	.	.	PUNCT
admet-535	291	1	j	j	PROPN
admet-535	291	2	med	med	PROPN
admet-535	291	3	chem	chem	NOUN
admet-535	291	4	47	47	NUM
admet-535	291	5	(	(	PUNCT
admet-535	291	6	2004	2004	NUM
admet-535	291	7	)	)	PUNCT
admet-535	291	8	4008	4008	NUM
admet-535	291	9	-	-	SYM
admet-535	291	10	4021	4021	NUM
admet-535	291	11	.	.	PUNCT
admet-535	292	1	[	[	X
admet-535	292	2	21	21	NUM
admet-535	292	3	]	]	X
admet-535	292	4	r.	r.	PROPN
admet-535	292	5	moaddel	moaddel	PROPN
admet-535	292	6	,	,	PUNCT
admet-535	292	7	k.	k.	PROPN
admet-535	292	8	jozwiak	jozwiak	PROPN
admet-535	292	9	,	,	PUNCT
admet-535	292	10	r.	r.	PROPN
admet-535	292	11	yamaguchi	yamaguchi	PROPN
admet-535	292	12	,	,	PUNCT
admet-535	292	13	c.	c.	PROPN
admet-535	292	14	cobello	cobello	PROPN
admet-535	292	15	,	,	PUNCT
admet-535	292	16	k.	k.	PROPN
admet-535	292	17	whittington	whittington	PROPN
admet-535	292	18	,	,	PUNCT
admet-535	292	19	t.k	t.k	PROPN
admet-535	292	20	.	.	PROPN
admet-535	292	21	sarkar	sarkar	PROPN
admet-535	292	22	,	,	PUNCT
admet-535	292	23	s.	s.	PROPN
admet-535	292	24	basak	basak	PROPN
admet-535	292	25	,	,	PUNCT
admet-535	292	26	i.w	i.w	PROPN
admet-535	292	27	.	.	PROPN
admet-535	292	28	wainer	wainer	PROPN
admet-535	292	29	.	.	PUNCT
admet-535	293	1	on	on	ADP
admet-535	293	2	-	-	PUNCT
admet-535	293	3	line	line	NOUN
admet-535	293	4	screening	screening	NOUN
admet-535	293	5	of	of	ADP
admet-535	293	6	conformationally	conformationally	ADV
admet-535	293	7	constrained	constrain	VERB
admet-535	293	8	nicotines	nicotine	NOUN
admet-535	293	9	and	and	CCONJ
admet-535	293	10	anabasines	anabasine	NOUN
admet-535	293	11	for	for	ADP
admet-535	293	12	agonist	agonist	NOUN
admet-535	293	13	activity	activity	NOUN
admet-535	293	14	at	at	ADP
admet-535	293	15	the	the	DET
admet-535	293	16	alpha3beta4and	alpha3beta4and	NUM
admet-535	293	17	alpha4beta2	alpha4beta2	ADJ
admet-535	293	18	-	-	ADJ
admet-535	293	19	nicotinic	nicotinic	ADJ
admet-535	293	20	acetylcholine	acetylcholine	NOUN
admet-535	293	21	receptors	receptor	NOUN
admet-535	293	22	using	use	VERB
admet-535	293	23	immobilized	immobilized	ADJ
admet-535	293	24	receptorbased	receptorbase	VERB
admet-535	293	25	liquid	liquid	ADJ
admet-535	293	26	chromatographic	chromatographic	ADJ
admet-535	293	27	stationary	stationary	ADJ
admet-535	293	28	phases	phase	NOUN
admet-535	293	29	.	.	PUNCT
admet-535	294	1	j	j	PROPN
admet-535	294	2	chromatogr	chromatogr	PROPN
admet-535	294	3	b	b	PROPN
admet-535	294	4	analyt	analyt	PROPN
admet-535	294	5	technol	technol	PROPN
admet-535	294	6	biomed	biome	VERB
admet-535	294	7	life	life	NOUN
admet-535	294	8	sci	sci	PROPN
admet-535	294	9	813	813	NUM
admet-535	294	10	(	(	PUNCT
admet-535	294	11	2004	2004	NUM
admet-535	294	12	)	)	PUNCT
admet-535	294	13	235	235	NUM
admet-535	294	14	-	-	SYM
admet-535	294	15	240	240	NUM
admet-535	294	16	.	.	PUNCT
admet-535	295	1	[	[	X
admet-535	295	2	22	22	NUM
admet-535	295	3	]	]	PUNCT
admet-535	295	4	r.	r.	PROPN
admet-535	295	5	moaddel	moaddel	PROPN
admet-535	295	6	,	,	PUNCT
admet-535	295	7	k.	k.	PROPN
admet-535	295	8	jozwiak	jozwiak	PROPN
admet-535	295	9	,	,	PUNCT
admet-535	295	10	k.	k.	PROPN
admet-535	295	11	whittington	whittington	PROPN
admet-535	295	12	,	,	PUNCT
admet-535	295	13	i.w	i.w	PROPN
admet-535	295	14	.	.	PROPN
admet-535	295	15	wainer	wainer	PROPN
admet-535	295	16	.	.	PUNCT
admet-535	296	1	conformational	conformational	ADJ
admet-535	296	2	mobility	mobility	NOUN
admet-535	296	3	of	of	ADP
admet-535	296	4	immobilized	immobilized	ADJ
admet-535	296	5	alpha3beta2	alpha3beta2	PROPN
admet-535	296	6	,	,	PUNCT
admet-535	296	7	alpha3beta4	alpha3beta4	NOUN
admet-535	296	8	,	,	PUNCT
admet-535	296	9	alpha4beta2	alpha4beta2	PRON
admet-535	296	10	,	,	PUNCT
admet-535	296	11	and	and	CCONJ
admet-535	296	12	alpha4beta4	alpha4beta4	NOUN
admet-535	296	13	nicotinic	nicotinic	ADJ
admet-535	296	14	acetylcholine	acetylcholine	NOUN
admet-535	296	15	receptors	receptor	NOUN
admet-535	296	16	.	.	PUNCT
admet-535	297	1	anal	anal	ADJ
admet-535	297	2	chem	chem	NOUN
admet-535	297	3	77	77	NUM
admet-535	297	4	(	(	PUNCT
admet-535	297	5	2005	2005	NUM
admet-535	297	6	)	)	PUNCT
admet-535	297	7	895	895	NUM
admet-535	297	8	-	-	SYM
admet-535	297	9	901	901	NUM
admet-535	297	10	.	.	PUNCT
admet-535	298	1	[	[	X
admet-535	298	2	23	23	NUM
admet-535	298	3	]	]	X
admet-535	298	4	r.	r.	PROPN
admet-535	298	5	moaddel	moaddel	PROPN
admet-535	298	6	,	,	PUNCT
admet-535	298	7	k.	k.	PROPN
admet-535	298	8	jozwiak	jozwiak	PROPN
admet-535	298	9	,	,	PUNCT
admet-535	298	10	r.	r.	PROPN
admet-535	298	11	yamaguchi	yamaguchi	PROPN
admet-535	298	12	,	,	PUNCT
admet-535	298	13	i.w	i.w	PROPN
admet-535	298	14	.	.	PROPN
admet-535	298	15	wainer	wainer	PROPN
admet-535	298	16	.	.	PUNCT
admet-535	299	1	direct	direct	ADJ
admet-535	299	2	chromatographic	chromatographic	ADJ
admet-535	299	3	determination	determination	NOUN
admet-535	299	4	of	of	ADP
admet-535	299	5	dissociation	dissociation	NOUN
admet-535	299	6	rate	rate	NOUN
admet-535	299	7	constants	constant	NOUN
admet-535	299	8	of	of	ADP
admet-535	299	9	ligand	ligand	NOUN
admet-535	299	10	-	-	PUNCT
admet-535	299	11	receptor	receptor	NOUN
admet-535	299	12	complexes	complex	NOUN
admet-535	299	13	:	:	PUNCT
admet-535	299	14	assessment	assessment	NOUN
admet-535	299	15	of	of	ADP
admet-535	299	16	the	the	DET
admet-535	299	17	interaction	interaction	NOUN
admet-535	299	18	of	of	ADP
admet-535	299	19	noncompetitive	noncompetitive	ADJ
admet-535	299	20	inhibitors	inhibitor	NOUN
admet-535	299	21	with	with	ADP
admet-535	299	22	an	an	DET
admet-535	299	23	immobilized	immobilized	ADJ
admet-535	299	24	nicotinic	nicotinic	ADJ
admet-535	299	25	acetylcholine	acetylcholine	NOUN
admet-535	299	26	receptor	receptor	NOUN
admet-535	299	27	-	-	PUNCT
admet-535	299	28	based	base	VERB
admet-535	299	29	liquid	liquid	ADJ
admet-535	299	30	chromatography	chromatography	NOUN
admet-535	299	31	stationary	stationary	ADJ
admet-535	299	32	phase	phase	NOUN
admet-535	299	33	.	.	PUNCT
admet-535	300	1	anal	anal	ADJ
admet-535	300	2	chem	chem	NOUN
admet-535	300	3	77	77	NUM
admet-535	300	4	(	(	PUNCT
admet-535	300	5	2005	2005	NUM
admet-535	300	6	)	)	PUNCT
admet-535	300	7	5421	5421	NUM
admet-535	300	8	-	-	SYM
admet-535	300	9	5426	5426	NUM
admet-535	300	10	.	.	PUNCT
admet-535	301	1	[	[	X
admet-535	301	2	24	24	NUM
admet-535	301	3	]	]	PUNCT
admet-535	301	4	k.	k.	PROPN
admet-535	301	5	jozwiak	jozwiak	PROPN
admet-535	301	6	,	,	PUNCT
admet-535	301	7	r.	r.	PROPN
admet-535	301	8	moaddel	moaddel	PROPN
admet-535	301	9	,	,	PUNCT
admet-535	301	10	r.	r.	PROPN
admet-535	301	11	yamaguchi	yamaguchi	PROPN
admet-535	301	12	,	,	PUNCT
admet-535	301	13	a.	a.	NOUN
admet-535	301	14	maciuk	maciuk	PROPN
admet-535	301	15	,	,	PUNCT
admet-535	301	16	i.w	i.w	PROPN
admet-535	301	17	.	.	PROPN
admet-535	301	18	wainer	wainer	PROPN
admet-535	301	19	.	.	PUNCT
admet-535	302	1	non	non	ADJ
admet-535	302	2	-	-	ADJ
admet-535	302	3	competitive	competitive	ADJ
admet-535	302	4	inhibitory	inhibitory	ADJ
admet-535	302	5	activities	activity	NOUN
admet-535	302	6	of	of	ADP
admet-535	302	7	morphinan	morphinan	PROPN
admet-535	302	8	and	and	CCONJ
admet-535	302	9	morphine	morphine	NOUN
admet-535	302	10	derivatives	derivative	NOUN
admet-535	302	11	at	at	ADP
admet-535	302	12	the	the	DET
admet-535	302	13	alpha	alpha	NOUN
admet-535	302	14	3	3	NUM
admet-535	302	15	beta	beta	NOUN
admet-535	302	16	4	4	NUM
admet-535	302	17	neuronal	neuronal	ADJ
admet-535	302	18	nicotinic	nicotinic	ADJ
admet-535	302	19	acetylcholine	acetylcholine	NOUN
admet-535	302	20	receptor	receptor	NOUN
admet-535	302	21	determined	determine	VERB
admet-535	302	22	using	use	VERB
admet-535	302	23	nonlinear	nonlinear	ADJ
admet-535	302	24	chromatography	chromatography	NOUN
admet-535	302	25	and	and	CCONJ
admet-535	302	26	chemometric	chemometric	ADJ
admet-535	302	27	techniques	technique	NOUN
admet-535	302	28	.	.	PUNCT
admet-535	303	1	pharm	pharm	NOUN
admet-535	303	2	res	re	VERB
admet-535	303	3	23	23	NUM
admet-535	303	4	(	(	PUNCT
admet-535	303	5	2006	2006	NUM
admet-535	303	6	)	)	PUNCT
admet-535	303	7	2175	2175	NUM
admet-535	303	8	-	-	SYM
admet-535	303	9	2182	2182	NUM
admet-535	303	10	.	.	PUNCT
admet-535	304	1	[	[	X
admet-535	304	2	25	25	NUM
admet-535	304	3	]	]	X
admet-535	304	4	r.	r.	PROPN
admet-535	304	5	moaddel	moaddel	PROPN
admet-535	304	6	,	,	PUNCT
admet-535	304	7	k.	k.	PROPN
admet-535	304	8	jozwiak	jozwiak	PROPN
admet-535	304	9	,	,	PUNCT
admet-535	304	10	i.w	i.w	PROPN
admet-535	304	11	.	.	PROPN
admet-535	304	12	wainer	wainer	PROPN
admet-535	304	13	.	.	PUNCT
admet-535	305	1	allosteric	allosteric	ADJ
admet-535	305	2	modifiers	modifier	NOUN
admet-535	305	3	of	of	ADP
admet-535	305	4	neuronal	neuronal	ADJ
admet-535	305	5	nicotinic	nicotinic	ADJ
admet-535	305	6	acetylcholine	acetylcholine	NOUN
admet-535	305	7	receptors	receptor	NOUN
admet-535	305	8	:	:	PUNCT
admet-535	305	9	new	new	ADJ
admet-535	305	10	methods	method	NOUN
admet-535	305	11	,	,	PUNCT
admet-535	305	12	new	new	ADJ
admet-535	305	13	opportunities	opportunity	NOUN
admet-535	305	14	.	.	PUNCT
admet-535	306	1	med	med	ADJ
admet-535	306	2	res	re	NOUN
admet-535	306	3	rev	rev	VERB
admet-535	306	4	27	27	NUM
admet-535	306	5	(	(	PUNCT
admet-535	306	6	2007	2007	NUM
admet-535	306	7	)	)	PUNCT
admet-535	306	8	723	723	NUM
admet-535	306	9	-	-	SYM
admet-535	306	10	753	753	NUM
admet-535	306	11	.	.	PUNCT
admet-535	307	1	[	[	X
admet-535	307	2	26	26	NUM
admet-535	307	3	]	]	PUNCT
admet-535	307	4	k.	k.	PROPN
admet-535	307	5	jozwiak	jozwiak	PROPN
admet-535	307	6	,	,	PUNCT
admet-535	307	7	s.	s.	PROPN
admet-535	307	8	ravichandran	ravichandran	PROPN
admet-535	307	9	,	,	PUNCT
admet-535	307	10	j.r	j.r	PROPN
admet-535	307	11	.	.	PROPN
admet-535	307	12	collins	collins	PROPN
admet-535	307	13	,	,	PUNCT
admet-535	307	14	r.	r.	PROPN
admet-535	307	15	moaddel	moaddel	PROPN
admet-535	307	16	,	,	PUNCT
admet-535	307	17	i.w	i.w	PROPN
admet-535	307	18	.	.	PROPN
admet-535	307	19	wainer	wainer	PROPN
admet-535	307	20	.	.	PUNCT
admet-535	308	1	interaction	interaction	NOUN
admet-535	308	2	of	of	ADP
admet-535	308	3	noncompetitive	noncompetitive	ADJ
admet-535	308	4	inhibitors	inhibitor	NOUN
admet-535	308	5	with	with	ADP
admet-535	308	6	the	the	DET
admet-535	308	7	alpha3beta2	alpha3beta2	PROPN
admet-535	308	8	nicotinic	nicotinic	ADJ
admet-535	308	9	acetylcholine	acetylcholine	NOUN
admet-535	308	10	receptor	receptor	NOUN
admet-535	308	11	investigated	investigate	VERB
admet-535	308	12	by	by	ADP
admet-535	308	13	affinity	affinity	NOUN
admet-535	308	14	chromatography	chromatography	NOUN
admet-535	308	15	and	and	CCONJ
admet-535	308	16	molecular	molecular	ADJ
admet-535	308	17	docking	docking	NOUN
admet-535	308	18	.	.	PUNCT
admet-535	309	1	j	j	PROPN
admet-535	309	2	med	med	PROPN
admet-535	309	3	chem	chem	NOUN
admet-535	309	4	50	50	NUM
admet-535	309	5	(	(	PUNCT
admet-535	309	6	2007	2007	NUM
admet-535	309	7	)	)	PUNCT
admet-535	309	8	6279	6279	NUM
admet-535	309	9	-	-	SYM
admet-535	309	10	6283	6283	NUM
admet-535	309	11	.	.	PUNCT
admet-535	310	1	[	[	X
admet-535	310	2	27	27	NUM
admet-535	310	3	]	]	X
admet-535	310	4	r.	r.	PROPN
admet-535	310	5	moaddel	moaddel	PROPN
admet-535	310	6	,	,	PUNCT
admet-535	310	7	r.v	r.v	PROPN
admet-535	310	8	.	.	PROPN
admet-535	310	9	oliveira	oliveira	PROPN
admet-535	310	10	,	,	PUNCT
admet-535	310	11	t.	t.	PROPN
admet-535	310	12	kimura	kimura	NOUN
admet-535	310	13	,	,	PUNCT
admet-535	310	14	p.	p.	NOUN
admet-535	310	15	hyppolite	hyppolite	PROPN
admet-535	310	16	,	,	PUNCT
admet-535	310	17	m.	m.	NOUN
admet-535	310	18	juhaszova	juhaszova	PROPN
admet-535	310	19	,	,	PUNCT
admet-535	310	20	y.	y.	PROPN
admet-535	310	21	xiao	xiao	PROPN
admet-535	310	22	,	,	PUNCT
admet-535	310	23	k.j	k.j	PROPN
admet-535	310	24	.	.	PUNCT
admet-535	310	25	kellar	kellar	PROPN
admet-535	310	26	,	,	PUNCT
admet-535	310	27	m.	m.	NOUN
admet-535	310	28	bernier	bernier	NOUN
admet-535	310	29	,	,	PUNCT
admet-535	310	30	i.w	i.w	PROPN
admet-535	310	31	.	.	PROPN
admet-535	310	32	wainer	wainer	PROPN
admet-535	310	33	.	.	PUNCT
admet-535	311	1	initial	initial	ADJ
admet-535	311	2	synthesis	synthesis	NOUN
admet-535	311	3	and	and	CCONJ
admet-535	311	4	characterization	characterization	NOUN
admet-535	311	5	of	of	ADP
admet-535	311	6	an	an	DET
admet-535	311	7	alpha7	alpha7	PROPN
admet-535	311	8	nicotinic	nicotinic	ADJ
admet-535	311	9	receptor	receptor	NOUN
admet-535	311	10	cellular	cellular	ADJ
admet-535	311	11	membrane	membrane	NOUN
admet-535	311	12	affinity	affinity	NOUN
admet-535	311	13	chromatography	chromatography	NOUN
admet-535	311	14	column	column	NOUN
admet-535	311	15	:	:	PUNCT
admet-535	311	16	effect	effect	NOUN
admet-535	311	17	of	of	ADP
admet-535	311	18	receptor	receptor	NOUN
admet-535	311	19	subtype	subtype	NOUN
admet-535	311	20	and	and	CCONJ
admet-535	311	21	cell	cell	NOUN
admet-535	311	22	type	type	NOUN
admet-535	311	23	.	.	PUNCT
admet-535	312	1	anal	anal	ADJ
admet-535	312	2	chem	chem	NOUN
admet-535	312	3	80	80	NUM
admet-535	312	4	(	(	PUNCT
admet-535	312	5	2008	2008	NUM
admet-535	312	6	)	)	PUNCT
admet-535	312	7	4854	4854	NUM
admet-535	312	8	.	.	PUNCT
admet-535	313	1	admet	admet	PROPN
admet-535	313	2	&	&	CCONJ
admet-535	313	3	dmpk	dmpk	PROPN
admet-535	313	4	6(3	6(3	PROPN
admet-535	313	5	)	)	PUNCT
admet-535	313	6	(	(	PUNCT
admet-535	313	7	2018	2018	NUM
admet-535	313	8	)	)	PUNCT
admet-535	313	9	200	200	NUM
admet-535	313	10	-	-	SYM
admet-535	313	11	214	214	NUM
admet-535	313	12	cell	cell	NOUN
admet-535	313	13	membrane	membrane	NOUN
admet-535	313	14	affinity	affinity	NOUN
admet-535	313	15	chromatography	chromatography	NOUN
admet-535	313	16	in	in	ADP
admet-535	313	17	drug	drug	NOUN
admet-535	313	18	discovery	discovery	NOUN
admet-535	313	19	doi	doi	PROPN
admet-535	313	20	:	:	PUNCT
admet-535	313	21	10.5599	10.5599	NUM
admet-535	313	22	/	/	SYM
admet-535	313	23	admet.535	admet.535	PROPN
admet-535	313	24	213	213	NUM
admet-535	313	25	[	[	SYM
admet-535	313	26	28	28	NUM
admet-535	313	27	]	]	X
admet-535	313	28	t.	t.	PROPN
admet-535	313	29	kitabatake	kitabatake	PROPN
admet-535	313	30	,	,	PUNCT
admet-535	313	31	r.	r.	PROPN
admet-535	313	32	moaddel	moaddel	PROPN
admet-535	313	33	,	,	PUNCT
admet-535	313	34	r.	r.	PROPN
admet-535	313	35	cole	cole	PROPN
admet-535	313	36	,	,	PUNCT
admet-535	313	37	m.	m.	NOUN
admet-535	313	38	gandhari	gandhari	PROPN
admet-535	313	39	,	,	PUNCT
admet-535	313	40	c.	c.	PROPN
admet-535	313	41	frazier	frazier	PROPN
admet-535	313	42	,	,	PUNCT
admet-535	313	43	j.	j.	PROPN
admet-535	313	44	hartenstein	hartenstein	PROPN
admet-535	313	45	,	,	PUNCT
admet-535	313	46	a.	a.	PROPN
admet-535	313	47	rosenberg	rosenberg	PROPN
admet-535	313	48	,	,	PUNCT
admet-535	313	49	m.	m.	NOUN
admet-535	313	50	bernier	bernier	NOUN
admet-535	313	51	,	,	PUNCT
admet-535	313	52	i.w	i.w	PROPN
admet-535	313	53	.	.	PROPN
admet-535	313	54	wainer	wainer	PROPN
admet-535	313	55	.	.	PUNCT
admet-535	314	1	characterization	characterization	NOUN
admet-535	314	2	of	of	ADP
admet-535	314	3	a	a	DET
admet-535	314	4	multiple	multiple	ADJ
admet-535	314	5	ligand	ligand	NOUN
admet-535	314	6	-	-	PUNCT
admet-535	314	7	gated	gate	VERB
admet-535	314	8	ion	ion	NOUN
admet-535	314	9	channel	channel	NOUN
admet-535	314	10	cellular	cellular	ADJ
admet-535	314	11	membrane	membrane	NOUN
admet-535	314	12	affinity	affinity	NOUN
admet-535	314	13	chromatography	chromatography	NOUN
admet-535	314	14	column	column	NOUN
admet-535	314	15	and	and	CCONJ
admet-535	314	16	identification	identification	NOUN
admet-535	314	17	of	of	ADP
admet-535	314	18	endogenously	endogenously	ADV
admet-535	314	19	expressed	express	VERB
admet-535	314	20	receptors	receptor	NOUN
admet-535	314	21	in	in	ADP
admet-535	314	22	astrocytoma	astrocytoma	NOUN
admet-535	314	23	cell	cell	NOUN
admet-535	314	24	lines	line	NOUN
admet-535	314	25	.	.	PUNCT
admet-535	315	1	anal	anal	ADJ
admet-535	315	2	chem	chem	NOUN
admet-535	315	3	80	80	NUM
admet-535	315	4	(	(	PUNCT
admet-535	315	5	2008	2008	NUM
admet-535	315	6	)	)	PUNCT
admet-535	315	7	8673	8673	NUM
admet-535	315	8	-	-	SYM
admet-535	315	9	8680	8680	NUM
admet-535	315	10	.	.	PUNCT
admet-535	316	1	[	[	X
admet-535	316	2	29	29	NUM
admet-535	316	3	]	]	X
admet-535	316	4	r.	r.	PROPN
admet-535	316	5	moaddel	moaddel	PROPN
admet-535	316	6	,	,	PUNCT
admet-535	316	7	j.f	j.f	PROPN
admet-535	316	8	.	.	PROPN
admet-535	316	9	cloix	cloix	PROPN
admet-535	316	10	,	,	PUNCT
admet-535	316	11	g.	g.	PROPN
admet-535	316	12	ertem	ertem	PROPN
admet-535	316	13	,	,	PUNCT
admet-535	316	14	i.w	i.w	PROPN
admet-535	316	15	.	.	PROPN
admet-535	316	16	wainer	wainer	PROPN
admet-535	316	17	.	.	PUNCT
admet-535	317	1	multiple	multiple	ADJ
admet-535	317	2	receptor	receptor	NOUN
admet-535	317	3	liquid	liquid	ADJ
admet-535	317	4	chromatographic	chromatographic	ADJ
admet-535	317	5	stationary	stationary	ADJ
admet-535	317	6	phases	phase	NOUN
admet-535	317	7	:	:	PUNCT
admet-535	317	8	the	the	DET
admet-535	317	9	co	co	NOUN
admet-535	317	10	-	-	NOUN
admet-535	317	11	immobilization	immobilization	NOUN
admet-535	317	12	of	of	ADP
admet-535	317	13	nicotinic	nicotinic	ADJ
admet-535	317	14	receptors	receptor	NOUN
admet-535	317	15	,	,	PUNCT
admet-535	317	16	gamma	gamma	NOUN
admet-535	317	17	-	-	PUNCT
admet-535	317	18	amino	amino	NOUN
admet-535	317	19	-	-	PUNCT
admet-535	317	20	butyric	butyric	ADJ
admet-535	317	21	acid	acid	NOUN
admet-535	317	22	receptors	receptor	NOUN
admet-535	317	23	,	,	PUNCT
admet-535	317	24	and	and	CCONJ
admet-535	317	25	nmethyl	nmethyl	ADJ
admet-535	317	26	d	d	ADJ
admet-535	317	27	-	-	PUNCT
admet-535	317	28	aspartate	aspartate	ADJ
admet-535	317	29	receptors	receptor	NOUN
admet-535	317	30	.	.	PUNCT
admet-535	318	1	pharm	pharm	NOUN
admet-535	318	2	res	re	VERB
admet-535	318	3	19	19	NUM
admet-535	318	4	(	(	PUNCT
admet-535	318	5	2002	2002	NUM
admet-535	318	6	)	)	PUNCT
admet-535	318	7	104	104	NUM
admet-535	318	8	-	-	SYM
admet-535	318	9	107	107	NUM
admet-535	318	10	.	.	PUNCT
admet-535	319	1	[	[	X
admet-535	319	2	30	30	NUM
admet-535	319	3	]	]	X
admet-535	319	4	l.	l.	PROPN
admet-535	319	5	ciesla	ciesla	PROPN
admet-535	319	6	,	,	PUNCT
admet-535	319	7	m.	m.	NOUN
admet-535	319	8	okine	okine	PROPN
admet-535	319	9	,	,	PUNCT
admet-535	319	10	a.	a.	PROPN
admet-535	319	11	rosenberg	rosenberg	PROPN
admet-535	319	12	,	,	PUNCT
admet-535	319	13	k.s.s	k.s.s	PROPN
admet-535	319	14	.	.	PROPN
admet-535	319	15	dossou	dossou	PROPN
admet-535	319	16	,	,	PUNCT
admet-535	319	17	l.	l.	PROPN
admet-535	319	18	toll	toll	PROPN
admet-535	319	19	,	,	PUNCT
admet-535	319	20	i.w	i.w	PROPN
admet-535	319	21	.	.	PROPN
admet-535	319	22	wainer	wainer	PROPN
admet-535	319	23	,	,	PUNCT
admet-535	319	24	r.	r.	PROPN
admet-535	319	25	moaddel	moaddel	PROPN
admet-535	319	26	.	.	PUNCT
admet-535	320	1	development	development	NOUN
admet-535	320	2	and	and	CCONJ
admet-535	320	3	characterization	characterization	NOUN
admet-535	320	4	of	of	ADP
admet-535	320	5	the	the	DET
admet-535	320	6	alpha3beta4alpha5	alpha3beta4alpha5	ADJ
admet-535	320	7	nicotinic	nicotinic	ADJ
admet-535	320	8	receptor	receptor	NOUN
admet-535	320	9	cellular	cellular	ADJ
admet-535	320	10	membrane	membrane	NOUN
admet-535	320	11	affinity	affinity	NOUN
admet-535	320	12	chromatography	chromatography	NOUN
admet-535	320	13	column	column	NOUN
admet-535	320	14	and	and	CCONJ
admet-535	320	15	its	its	PRON
admet-535	320	16	application	application	NOUN
admet-535	320	17	for	for	ADP
admet-535	320	18	on	on	ADP
admet-535	320	19	line	line	NOUN
admet-535	320	20	screening	screening	NOUN
admet-535	320	21	of	of	ADP
admet-535	320	22	plant	plant	NOUN
admet-535	320	23	extracts	extract	NOUN
admet-535	320	24	.	.	PUNCT
admet-535	321	1	j	j	PROPN
admet-535	321	2	chromatogr	chromatogr	VERB
admet-535	321	3	a	a	DET
admet-535	321	4	1431	1431	NUM
admet-535	321	5	(	(	PUNCT
admet-535	321	6	2016	2016	NUM
admet-535	321	7	)	)	PUNCT
admet-535	321	8	138	138	NUM
admet-535	321	9	-	-	SYM
admet-535	321	10	144	144	NUM
admet-535	321	11	.	.	PUNCT
admet-535	322	1	[	[	X
admet-535	322	2	31	31	NUM
admet-535	322	3	]	]	PUNCT
admet-535	322	4	f.	f.	PROPN
admet-535	322	5	beigi	beigi	PROPN
admet-535	322	6	,	,	PUNCT
admet-535	322	7	i.w	i.w	PROPN
admet-535	322	8	.	.	PROPN
admet-535	322	9	wainer	wainer	PROPN
admet-535	322	10	.	.	PUNCT
admet-535	323	1	syntheses	synthesis	NOUN
admet-535	323	2	of	of	ADP
admet-535	323	3	immobilized	immobilize	VERB
admet-535	323	4	g	g	PROPN
admet-535	323	5	protein	protein	NOUN
admet-535	323	6	-	-	PUNCT
admet-535	323	7	coupled	couple	VERB
admet-535	323	8	receptor	receptor	NOUN
admet-535	323	9	chromatographic	chromatographic	ADJ
admet-535	323	10	stationary	stationary	ADJ
admet-535	323	11	phases	phase	NOUN
admet-535	323	12	:	:	PUNCT
admet-535	323	13	characterization	characterization	NOUN
admet-535	323	14	of	of	ADP
admet-535	323	15	immobilized	immobilized	ADJ
admet-535	323	16	mu	mu	PROPN
admet-535	323	17	and	and	CCONJ
admet-535	323	18	kappa	kappa	VERB
admet-535	323	19	opioid	opioid	ADJ
admet-535	323	20	receptors	receptor	NOUN
admet-535	323	21	.	.	PUNCT
admet-535	324	1	anal	anal	ADJ
admet-535	324	2	chem	chem	NOUN
admet-535	324	3	75	75	NUM
admet-535	324	4	(	(	PUNCT
admet-535	324	5	2003	2003	NUM
admet-535	324	6	)	)	PUNCT
admet-535	324	7	4480	4480	NUM
admet-535	324	8	-	-	SYM
admet-535	324	9	4485	4485	NUM
admet-535	324	10	.	.	PUNCT
admet-535	325	1	[	[	X
admet-535	325	2	32	32	NUM
admet-535	325	3	]	]	PUNCT
admet-535	325	4	f.	f.	PROPN
admet-535	325	5	beigi	beigi	PROPN
admet-535	325	6	,	,	PUNCT
admet-535	325	7	k.	k.	PROPN
admet-535	325	8	chakir	chakir	PROPN
admet-535	325	9	,	,	PUNCT
admet-535	325	10	r.p	r.p	PROPN
admet-535	325	11	.	.	PROPN
admet-535	325	12	xiao	xiao	PROPN
admet-535	325	13	,	,	PUNCT
admet-535	325	14	i.w	i.w	PROPN
admet-535	325	15	.	.	PROPN
admet-535	325	16	wainer	wainer	PROPN
admet-535	325	17	.	.	PUNCT
admet-535	326	1	g	g	NOUN
admet-535	326	2	-	-	PUNCT
admet-535	326	3	protein	protein	NOUN
admet-535	326	4	-	-	PUNCT
admet-535	326	5	coupled	couple	VERB
admet-535	326	6	receptor	receptor	NOUN
admet-535	326	7	chromatographic	chromatographic	ADJ
admet-535	326	8	stationary	stationary	ADJ
admet-535	326	9	phases	phase	NOUN
admet-535	326	10	.	.	PUNCT
admet-535	327	1	2	2	X
admet-535	327	2	.	.	X
admet-535	327	3	ligand	ligand	NOUN
admet-535	327	4	-	-	PUNCT
admet-535	327	5	induced	induce	VERB
admet-535	327	6	conformational	conformational	ADJ
admet-535	327	7	mobility	mobility	NOUN
admet-535	327	8	in	in	ADP
admet-535	327	9	an	an	DET
admet-535	327	10	immobilized	immobilized	ADJ
admet-535	327	11	beta2	beta2	NOUN
admet-535	327	12	-	-	PUNCT
admet-535	327	13	adrenergic	adrenergic	ADJ
admet-535	327	14	receptor	receptor	NOUN
admet-535	327	15	.	.	PUNCT
admet-535	328	1	anal	anal	ADJ
admet-535	328	2	chem	chem	NOUN
admet-535	328	3	76	76	NUM
admet-535	328	4	(	(	PUNCT
admet-535	328	5	2004	2004	NUM
admet-535	328	6	)	)	PUNCT
admet-535	328	7	7187	7187	NUM
admet-535	328	8	-	-	SYM
admet-535	328	9	7193	7193	NUM
admet-535	328	10	.	.	PUNCT
admet-535	329	1	[	[	X
admet-535	329	2	33	33	NUM
admet-535	329	3	]	]	PUNCT
admet-535	329	4	r.	r.	PROPN
admet-535	329	5	moaddel	moaddel	PROPN
admet-535	329	6	,	,	PUNCT
admet-535	329	7	h.k	h.k	PROPN
admet-535	329	8	.	.	PROPN
admet-535	329	9	musyimi	musyimi	PROPN
admet-535	329	10	,	,	PUNCT
admet-535	329	11	m.	m.	NOUN
admet-535	329	12	sanghvi	sanghvi	PROPN
admet-535	329	13	,	,	PUNCT
admet-535	329	14	c.	c.	PROPN
admet-535	329	15	bashore	bashore	PROPN
admet-535	329	16	,	,	PUNCT
admet-535	329	17	c.r	c.r	PROPN
admet-535	329	18	.	.	PROPN
admet-535	329	19	frazier	frazier	PROPN
admet-535	329	20	,	,	PUNCT
admet-535	329	21	m.	m.	NOUN
admet-535	329	22	khadeer	khadeer	NOUN
admet-535	329	23	,	,	PUNCT
admet-535	329	24	p.	p.	PROPN
admet-535	329	25	bhatia	bhatia	PROPN
admet-535	329	26	,	,	PUNCT
admet-535	329	27	i.w	i.w	PROPN
admet-535	329	28	.	.	PROPN
admet-535	329	29	wainer	wainer	PROPN
admet-535	329	30	.	.	PUNCT
admet-535	330	1	synthesis	synthesis	NOUN
admet-535	330	2	and	and	CCONJ
admet-535	330	3	characterization	characterization	NOUN
admet-535	330	4	of	of	ADP
admet-535	330	5	a	a	DET
admet-535	330	6	cellular	cellular	ADJ
admet-535	330	7	membrane	membrane	NOUN
admet-535	330	8	affinity	affinity	NOUN
admet-535	330	9	chromatography	chromatography	NOUN
admet-535	330	10	column	column	NOUN
admet-535	330	11	containing	contain	VERB
admet-535	330	12	histamine	histamine	NOUN
admet-535	330	13	1	1	NUM
admet-535	330	14	and	and	CCONJ
admet-535	330	15	p2y(1	p2y(1	ADJ
admet-535	330	16	)	)	PUNCT
admet-535	330	17	receptors	receptor	NOUN
admet-535	330	18	:	:	PUNCT
admet-535	330	19	a	a	DET
admet-535	330	20	multiple	multiple	ADJ
admet-535	330	21	g	g	NOUN
admet-535	330	22	-	-	PUNCT
admet-535	330	23	protein	protein	NOUN
admet-535	330	24	coupled	couple	VERB
admet-535	330	25	receptor	receptor	NOUN
admet-535	330	26	column	column	NOUN
admet-535	330	27	.	.	PUNCT
admet-535	331	1	j	j	PROPN
admet-535	331	2	pharm	pharm	PROPN
admet-535	331	3	biomed	biome	VERB
admet-535	331	4	anal	anal	ADJ
admet-535	331	5	52	52	NUM
admet-535	331	6	(	(	PUNCT
admet-535	331	7	2010	2010	NUM
admet-535	331	8	)	)	PUNCT
admet-535	331	9	416	416	NUM
admet-535	331	10	-	-	SYM
admet-535	331	11	419	419	NUM
admet-535	331	12	.	.	PUNCT
admet-535	332	1	[	[	X
admet-535	332	2	34	34	NUM
admet-535	332	3	]	]	X
admet-535	332	4	r.	r.	PROPN
admet-535	332	5	moaddel	moaddel	PROPN
admet-535	332	6	,	,	PUNCT
admet-535	332	7	a.	a.	PROPN
admet-535	332	8	rosenberg	rosenberg	PROPN
admet-535	332	9	,	,	PUNCT
admet-535	332	10	k.	k.	PROPN
admet-535	332	11	spelman	spelman	PROPN
admet-535	332	12	,	,	PUNCT
admet-535	332	13	j.	j.	PROPN
admet-535	332	14	frazier	frazier	PROPN
admet-535	332	15	,	,	PUNCT
admet-535	332	16	c.	c.	PROPN
admet-535	332	17	frazier	frazier	PROPN
admet-535	332	18	,	,	PUNCT
admet-535	332	19	s.	s.	PROPN
admet-535	332	20	nocerino	nocerino	PROPN
admet-535	332	21	,	,	PUNCT
admet-535	332	22	a.	a.	NOUN
admet-535	332	23	brizzi	brizzi	NOUN
admet-535	332	24	,	,	PUNCT
admet-535	332	25	c.	c.	PROPN
admet-535	332	26	mugnaini	mugnaini	PROPN
admet-535	332	27	,	,	PUNCT
admet-535	332	28	i.w	i.w	PROPN
admet-535	332	29	.	.	PROPN
admet-535	332	30	wainer	wainer	PROPN
admet-535	332	31	.	.	PUNCT
admet-535	333	1	development	development	NOUN
admet-535	333	2	and	and	CCONJ
admet-535	333	3	characterization	characterization	NOUN
admet-535	333	4	of	of	ADP
admet-535	333	5	immobilized	immobilized	ADJ
admet-535	333	6	cannabinoid	cannabinoid	NOUN
admet-535	333	7	receptor	receptor	NOUN
admet-535	333	8	(	(	PUNCT
admet-535	333	9	cb1	cb1	PROPN
admet-535	333	10	/	/	SYM
admet-535	333	11	cb2	cb2	PROPN
admet-535	333	12	)	)	PUNCT
admet-535	333	13	open	open	ADJ
admet-535	333	14	tubular	tubular	ADJ
admet-535	333	15	column	column	NOUN
admet-535	333	16	for	for	ADP
admet-535	333	17	on	on	ADP
admet-535	333	18	-	-	PUNCT
admet-535	333	19	line	line	NOUN
admet-535	333	20	screening	screening	NOUN
admet-535	333	21	.	.	PUNCT
admet-535	334	1	anal	anal	ADJ
admet-535	334	2	biochem	biochem	NOUN
admet-535	334	3	412	412	NUM
admet-535	334	4	(	(	PUNCT
admet-535	334	5	2011	2011	NUM
admet-535	334	6	)	)	PUNCT
admet-535	334	7	85	85	NUM
admet-535	334	8	-	-	SYM
admet-535	334	9	91	91	NUM
admet-535	334	10	.	.	PUNCT
admet-535	335	1	[	[	X
admet-535	335	2	35	35	NUM
admet-535	335	3	]	]	X
admet-535	335	4	i.	i.	PROPN
admet-535	335	5	gonzalez	gonzalez	PROPN
admet-535	335	6	-	-	PUNCT
admet-535	335	7	mariscal	mariscal	PROPN
admet-535	335	8	,	,	PUNCT
admet-535	335	9	s.m	s.m	PROPN
admet-535	335	10	.	.	PUNCT
admet-535	335	11	krzysik	krzysik	PROPN
admet-535	335	12	-	-	PUNCT
admet-535	335	13	walker	walker	PROPN
admet-535	335	14	,	,	PUNCT
admet-535	335	15	m.e	m.e	PROPN
admet-535	335	16	.	.	PROPN
admet-535	335	17	doyle	doyle	PROPN
admet-535	335	18	,	,	PUNCT
admet-535	335	19	q.r	q.r	PROPN
admet-535	335	20	.	.	PROPN
admet-535	335	21	liu	liu	PROPN
admet-535	335	22	,	,	PUNCT
admet-535	335	23	r.	r.	PROPN
admet-535	335	24	cimbro	cimbro	PROPN
admet-535	335	25	,	,	PUNCT
admet-535	335	26	s.	s.	PROPN
admet-535	335	27	santa	santa	PROPN
admet-535	335	28	-	-	PUNCT
admet-535	335	29	cruz	cruz	PROPN
admet-535	335	30	calvo	calvo	PROPN
admet-535	335	31	,	,	PUNCT
admet-535	335	32	s.	s.	PROPN
admet-535	335	33	ghosh	ghosh	PROPN
admet-535	335	34	,	,	PUNCT
admet-535	335	35	l.	l.	PROPN
admet-535	335	36	ciesla	ciesla	PROPN
admet-535	335	37	,	,	PUNCT
admet-535	335	38	r.	r.	PROPN
admet-535	335	39	moaddel	moaddel	PROPN
admet-535	335	40	,	,	PUNCT
admet-535	335	41	o.d	o.d	PROPN
admet-535	335	42	.	.	PROPN
admet-535	335	43	carlson	carlson	PROPN
admet-535	335	44	,	,	PUNCT
admet-535	335	45	r.p	r.p	PROPN
admet-535	335	46	.	.	PROPN
admet-535	335	47	witek	witek	PROPN
admet-535	335	48	,	,	PUNCT
admet-535	335	49	j.f	j.f	PROPN
admet-535	335	50	.	.	PROPN
admet-535	335	51	o'connell	o'connell	PROPN
admet-535	335	52	,	,	PUNCT
admet-535	335	53	j.m	j.m	PROPN
admet-535	335	54	.	.	PROPN
admet-535	335	55	egan	egan	PROPN
admet-535	335	56	.	.	PUNCT
admet-535	336	1	human	human	PROPN
admet-535	336	2	cb1	cb1	PROPN
admet-535	336	3	receptor	receptor	NOUN
admet-535	336	4	isoforms	isoform	NOUN
admet-535	336	5	,	,	PUNCT
admet-535	336	6	present	present	ADJ
admet-535	336	7	in	in	ADP
admet-535	336	8	hepatocytes	hepatocyte	NOUN
admet-535	336	9	and	and	CCONJ
admet-535	336	10	beta	beta	NOUN
admet-535	336	11	-	-	PUNCT
admet-535	336	12	cells	cell	NOUN
admet-535	336	13	,	,	PUNCT
admet-535	336	14	are	be	AUX
admet-535	336	15	involved	involve	VERB
admet-535	336	16	in	in	ADP
admet-535	336	17	regulating	regulate	VERB
admet-535	336	18	metabolism	metabolism	NOUN
admet-535	336	19	.	.	PUNCT
admet-535	337	1	sci	sci	PROPN
admet-535	337	2	rep	rep	PROPN
admet-535	337	3	6	6	NUM
admet-535	337	4	(	(	PUNCT
admet-535	337	5	2016	2016	NUM
admet-535	337	6	)	)	PUNCT
admet-535	337	7	33302	33302	NUM
admet-535	337	8	.	.	PUNCT
admet-535	338	1	[	[	X
admet-535	338	2	36	36	NUM
admet-535	338	3	]	]	X
admet-535	338	4	r.	r.	PROPN
admet-535	338	5	moaddel	moaddel	PROPN
admet-535	338	6	,	,	PUNCT
admet-535	338	7	l.	l.	PROPN
admet-535	338	8	lu	lu	PROPN
admet-535	338	9	,	,	PUNCT
admet-535	338	10	m.	m.	PROPN
admet-535	338	11	baynham	baynham	PROPN
admet-535	338	12	,	,	PUNCT
admet-535	338	13	i.w	i.w	PROPN
admet-535	338	14	.	.	PROPN
admet-535	338	15	wainer	wainer	PROPN
admet-535	338	16	.	.	PUNCT
admet-535	339	1	immobilized	immobilized	PROPN
admet-535	339	2	receptorand	receptorand	NOUN
admet-535	339	3	transporter	transporter	NOUN
admet-535	339	4	-	-	PUNCT
admet-535	339	5	based	base	VERB
admet-535	339	6	liquid	liquid	ADJ
admet-535	339	7	chromatographic	chromatographic	ADJ
admet-535	339	8	phases	phase	NOUN
admet-535	339	9	for	for	ADP
admet-535	339	10	on	on	ADP
admet-535	339	11	-	-	PUNCT
admet-535	339	12	line	line	NOUN
admet-535	339	13	pharmacological	pharmacological	ADJ
admet-535	339	14	and	and	CCONJ
admet-535	339	15	biochemical	biochemical	ADJ
admet-535	339	16	studies	study	NOUN
admet-535	339	17	:	:	PUNCT
admet-535	339	18	a	a	DET
admet-535	339	19	mini	mini	NOUN
admet-535	339	20	-	-	NOUN
admet-535	339	21	review	review	NOUN
admet-535	339	22	.	.	PUNCT
admet-535	340	1	j	j	PROPN
admet-535	340	2	chromatogr	chromatogr	PROPN
admet-535	340	3	b	b	PROPN
admet-535	340	4	analyt	analyt	PROPN
admet-535	340	5	technol	technol	PROPN
admet-535	340	6	biomed	biome	VERB
admet-535	340	7	life	life	NOUN
admet-535	340	8	sci	sci	PROPN
admet-535	340	9	768	768	NUM
admet-535	340	10	(	(	PUNCT
admet-535	340	11	2002	2002	NUM
admet-535	340	12	)	)	PUNCT
admet-535	340	13	41	41	NUM
admet-535	340	14	-	-	SYM
admet-535	340	15	53	53	NUM
admet-535	340	16	.	.	PUNCT
admet-535	341	1	[	[	X
admet-535	341	2	37	37	NUM
admet-535	341	3	]	]	X
admet-535	341	4	r.	r.	PROPN
admet-535	341	5	moaddel	moaddel	PROPN
admet-535	341	6	,	,	PUNCT
admet-535	341	7	p.l	p.l	PROPN
admet-535	341	8	.	.	PROPN
admet-535	341	9	bullock	bullock	PROPN
admet-535	341	10	,	,	PUNCT
admet-535	341	11	i.w	i.w	PROPN
admet-535	341	12	.	.	PROPN
admet-535	341	13	wainer	wainer	PROPN
admet-535	341	14	.	.	PUNCT
admet-535	342	1	development	development	NOUN
admet-535	342	2	and	and	CCONJ
admet-535	342	3	characterization	characterization	NOUN
admet-535	342	4	of	of	ADP
admet-535	342	5	an	an	DET
admet-535	342	6	open	open	ADJ
admet-535	342	7	tubular	tubular	ADJ
admet-535	342	8	column	column	NOUN
admet-535	342	9	containing	contain	VERB
admet-535	342	10	immobilized	immobilize	VERB
admet-535	342	11	p	p	NOUN
admet-535	342	12	-	-	PUNCT
admet-535	342	13	glycoprotein	glycoprotein	NOUN
admet-535	342	14	for	for	ADP
admet-535	342	15	rapid	rapid	ADJ
admet-535	342	16	on	on	ADP
admet-535	342	17	-	-	PUNCT
admet-535	342	18	line	line	NOUN
admet-535	342	19	screening	screening	NOUN
admet-535	342	20	for	for	ADP
admet-535	342	21	p	p	NOUN
admet-535	342	22	-	-	PUNCT
admet-535	342	23	glycoprotein	glycoprotein	NOUN
admet-535	342	24	substrates	substrate	NOUN
admet-535	342	25	.	.	PUNCT
admet-535	343	1	j	j	PROPN
admet-535	343	2	chromatogr	chromatogr	PROPN
admet-535	343	3	b	b	PROPN
admet-535	343	4	analyt	analyt	PROPN
admet-535	343	5	technol	technol	PROPN
admet-535	343	6	biomed	biome	VERB
admet-535	343	7	life	life	NOUN
admet-535	343	8	sci	sci	PROPN
admet-535	343	9	799	799	NUM
admet-535	343	10	(	(	PUNCT
admet-535	343	11	2004	2004	NUM
admet-535	343	12	)	)	PUNCT
admet-535	343	13	255	255	NUM
admet-535	343	14	-	-	SYM
admet-535	343	15	263	263	NUM
admet-535	343	16	.	.	PUNCT
admet-535	344	1	[	[	X
admet-535	344	2	38	38	NUM
admet-535	344	3	]	]	PUNCT
admet-535	344	4	r.	r.	PROPN
admet-535	344	5	moaddel	moaddel	PROPN
admet-535	344	6	,	,	PUNCT
admet-535	344	7	r.	r.	PROPN
admet-535	344	8	hamid	hamid	PROPN
admet-535	344	9	,	,	PUNCT
admet-535	344	10	s.	s.	PROPN
admet-535	344	11	patel	patel	PROPN
admet-535	344	12	,	,	PUNCT
admet-535	344	13	p.l	p.l	PROPN
admet-535	344	14	.	.	PROPN
admet-535	344	15	bullock	bullock	PROPN
admet-535	344	16	,	,	PUNCT
admet-535	344	17	i.w	i.w	PROPN
admet-535	344	18	.	.	PROPN
admet-535	344	19	wainer	wainer	PROPN
admet-535	344	20	.	.	PUNCT
admet-535	345	1	identification	identification	NOUN
admet-535	345	2	of	of	ADP
admet-535	345	3	p	p	NOUN
admet-535	345	4	-	-	PUNCT
admet-535	345	5	glycoprotein	glycoprotein	NOUN
admet-535	345	6	substrates	substrate	NOUN
admet-535	345	7	using	use	VERB
admet-535	345	8	open	open	ADJ
admet-535	345	9	tubular	tubular	ADJ
admet-535	345	10	chromatography	chromatography	NOUN
admet-535	345	11	on	on	ADP
admet-535	345	12	an	an	DET
admet-535	345	13	immobilized	immobilized	ADJ
admet-535	345	14	p	p	NOUN
admet-535	345	15	-	-	PUNCT
admet-535	345	16	glycoprotein	glycoprotein	NOUN
admet-535	345	17	column	column	NOUN
admet-535	345	18	:	:	PUNCT
admet-535	345	19	comparison	comparison	NOUN
admet-535	345	20	of	of	ADP
admet-535	345	21	chromatographic	chromatographic	ADJ
admet-535	345	22	results	result	NOUN
admet-535	345	23	with	with	ADP
admet-535	345	24	caco-2	caco-2	NUM
admet-535	345	25	permeability	permeability	NOUN
admet-535	345	26	.	.	PUNCT
admet-535	346	1	anal	anal	PROPN
admet-535	346	2	chim	chim	PROPN
admet-535	346	3	acta	acta	PROPN
admet-535	346	4	578	578	NUM
admet-535	346	5	(	(	PUNCT
admet-535	346	6	2006	2006	NUM
admet-535	346	7	)	)	PUNCT
admet-535	346	8	25	25	NUM
admet-535	346	9	-	-	SYM
admet-535	346	10	30	30	NUM
admet-535	346	11	.	.	PUNCT
admet-535	347	1	[	[	X
admet-535	347	2	39	39	NUM
admet-535	347	3	]	]	X
admet-535	347	4	k.l	k.l	PROPN
admet-535	347	5	.	.	PROPN
admet-535	347	6	habicht	habicht	PROPN
admet-535	347	7	,	,	PUNCT
admet-535	347	8	n.s	n.s	PROPN
admet-535	347	9	.	.	PROPN
admet-535	347	10	singh	singh	PROPN
admet-535	347	11	,	,	PUNCT
admet-535	347	12	m.a	m.a	PROPN
admet-535	347	13	.	.	PROPN
admet-535	347	14	khadeer	khadeer	PROPN
admet-535	347	15	,	,	PUNCT
admet-535	347	16	r.	r.	PROPN
admet-535	347	17	shimmo	shimmo	NOUN
admet-535	347	18	,	,	PUNCT
admet-535	347	19	i.w	i.w	PROPN
admet-535	347	20	.	.	PROPN
admet-535	347	21	wainer	wainer	PROPN
admet-535	347	22	,	,	PUNCT
admet-535	347	23	r.	r.	PROPN
admet-535	347	24	moaddel	moaddel	PROPN
admet-535	347	25	.	.	PUNCT
admet-535	348	1	characterization	characterization	NOUN
admet-535	348	2	of	of	ADP
admet-535	348	3	a	a	DET
admet-535	348	4	multiple	multiple	NOUN
admet-535	348	5	endogenously	endogenously	ADV
admet-535	348	6	expressed	express	VERB
admet-535	348	7	adenosine	adenosine	ADJ
admet-535	348	8	triphosphate	triphosphate	NOUN
admet-535	348	9	-	-	PUNCT
admet-535	348	10	binding	bind	VERB
admet-535	348	11	cassette	cassette	NOUN
admet-535	348	12	transporters	transporter	NOUN
admet-535	348	13	using	use	VERB
admet-535	348	14	nuclear	nuclear	ADJ
admet-535	348	15	and	and	CCONJ
admet-535	348	16	cellular	cellular	ADJ
admet-535	348	17	membrane	membrane	NOUN
admet-535	348	18	affinity	affinity	NOUN
admet-535	348	19	chromatography	chromatography	NOUN
admet-535	348	20	columns	column	NOUN
admet-535	348	21	.	.	PUNCT
admet-535	349	1	j	j	PROPN
admet-535	349	2	chromatogr	chromatogr	VERB
admet-535	349	3	a	a	DET
admet-535	349	4	1339	1339	NUM
admet-535	349	5	(	(	PUNCT
admet-535	349	6	2014	2014	NUM
admet-535	349	7	)	)	PUNCT
admet-535	349	8	80	80	NUM
admet-535	349	9	-	-	SYM
admet-535	349	10	85	85	NUM
admet-535	349	11	.	.	PUNCT
admet-535	350	1	[	[	X
admet-535	350	2	40	40	NUM
admet-535	350	3	]	]	PUNCT
admet-535	350	4	s.	s.	PROPN
admet-535	350	5	wang	wang	PROPN
admet-535	350	6	,	,	PUNCT
admet-535	350	7	m.	m.	NOUN
admet-535	350	8	sun	sun	PROPN
admet-535	350	9	,	,	PUNCT
admet-535	350	10	y.	y.	PROPN
admet-535	350	11	zhang	zhang	PROPN
admet-535	350	12	,	,	PUNCT
admet-535	350	13	h.	h.	PROPN
admet-535	350	14	du	du	PROPN
admet-535	350	15	,	,	PUNCT
admet-535	350	16	l.	l.	PROPN
admet-535	350	17	he	he	PRON
admet-535	350	18	.	.	PUNCT
admet-535	351	1	a	a	DET
admet-535	351	2	new	new	ADJ
admet-535	351	3	a431	a431	PROPN
admet-535	351	4	/	/	SYM
admet-535	351	5	cell	cell	NOUN
admet-535	351	6	membrane	membrane	NOUN
admet-535	351	7	chromatography	chromatography	NOUN
admet-535	351	8	and	and	CCONJ
admet-535	351	9	online	online	ADJ
admet-535	351	10	high	high	ADJ
admet-535	351	11	performance	performance	NOUN
admet-535	351	12	liquid	liquid	NOUN
admet-535	351	13	chromatography	chromatography	NOUN
admet-535	351	14	/	/	SYM
admet-535	351	15	mass	mass	NOUN
admet-535	351	16	spectrometry	spectrometry	NOUN
admet-535	351	17	method	method	NOUN
admet-535	351	18	for	for	ADP
admet-535	351	19	screening	screen	VERB
admet-535	351	20	epidermal	epidermal	ADJ
admet-535	351	21	growth	growth	NOUN
admet-535	351	22	factor	factor	NOUN
admet-535	351	23	receptor	receptor	NOUN
admet-535	351	24	antagonists	antagonist	NOUN
admet-535	351	25	from	from	ADP
admet-535	351	26	radix	radix	PROPN
admet-535	351	27	sophorae	sophorae	PROPN
admet-535	351	28	flavescentis	flavescentis	PROPN
admet-535	351	29	.	.	PUNCT
admet-535	352	1	j	j	PROPN
admet-535	352	2	chromatogr	chromatogr	VERB
admet-535	352	3	a	a	DET
admet-535	352	4	1217	1217	NUM
admet-535	352	5	(	(	PUNCT
admet-535	352	6	2010	2010	NUM
admet-535	352	7	)	)	PUNCT
admet-535	352	8	52465252	52465252	NUM
admet-535	352	9	.	.	PUNCT
admet-535	353	1	[	[	X
admet-535	353	2	41	41	NUM
admet-535	353	3	]	]	X
admet-535	353	4	l.c	l.c	PROPN
admet-535	353	5	.	.	PUNCT
admet-535	354	1	he	he	PRON
admet-535	354	2	,	,	PUNCT
admet-535	354	3	s.c	s.c	PROPN
admet-535	354	4	.	.	PROPN
admet-535	354	5	wang	wang	PROPN
admet-535	354	6	,	,	PUNCT
admet-535	354	7	g.d	g.d	PROPN
admet-535	354	8	.	.	PROPN
admet-535	354	9	yang	yang	PROPN
admet-535	354	10	,	,	PUNCT
admet-535	354	11	y.m	y.m	PROPN
admet-535	354	12	.	.	PROPN
admet-535	354	13	zhang	zhang	PROPN
admet-535	354	14	,	,	PUNCT
admet-535	354	15	c.h	c.h	PROPN
admet-535	354	16	.	.	PROPN
admet-535	354	17	wang	wang	PROPN
admet-535	354	18	,	,	PUNCT
admet-535	354	19	b.x	b.x	PROPN
admet-535	354	20	.	.	PROPN
admet-535	354	21	yuan	yuan	PROPN
admet-535	354	22	,	,	PUNCT
admet-535	354	23	x.f	x.f	PROPN
admet-535	354	24	.	.	PUNCT
admet-535	355	1	hou	hou	PROPN
admet-535	355	2	.	.	PUNCT
admet-535	356	1	progress	progress	NOUN
admet-535	356	2	in	in	ADP
admet-535	356	3	cell	cell	NOUN
admet-535	356	4	membrane	membrane	NOUN
admet-535	356	5	chromatography	chromatography	NOUN
admet-535	356	6	.	.	PUNCT
admet-535	357	1	drug	drug	NOUN
admet-535	357	2	discov	discov	PROPN
admet-535	357	3	ther	ther	PROPN
admet-535	357	4	1	1	NUM
admet-535	357	5	(	(	PUNCT
admet-535	357	6	2007	2007	NUM
admet-535	357	7	)	)	PUNCT
admet-535	357	8	104	104	NUM
admet-535	357	9	-	-	SYM
admet-535	357	10	107	107	NUM
admet-535	357	11	.	.	PUNCT
admet-535	358	1	[	[	X
admet-535	358	2	42	42	NUM
admet-535	358	3	]	]	PUNCT
admet-535	358	4	s.	s.	PROPN
admet-535	358	5	han	han	PROPN
admet-535	358	6	,	,	PUNCT
admet-535	358	7	y.	y.	PROPN
admet-535	358	8	lv	lv	PROPN
admet-535	358	9	,	,	PUNCT
admet-535	358	10	f.	f.	PROPN
admet-535	358	11	wei	wei	PROPN
admet-535	358	12	,	,	PUNCT
admet-535	358	13	j.	j.	PROPN
admet-535	358	14	fu	fu	PROPN
admet-535	358	15	,	,	PUNCT
admet-535	358	16	q.	q.	PROPN
admet-535	358	17	hu	hu	PROPN
admet-535	358	18	,	,	PUNCT
admet-535	358	19	s.	s.	PROPN
admet-535	358	20	wang	wang	PROPN
admet-535	358	21	.	.	PUNCT
admet-535	359	1	screening	screen	VERB
admet-535	359	2	of	of	ADP
admet-535	359	3	bioactive	bioactive	ADJ
admet-535	359	4	components	component	NOUN
admet-535	359	5	from	from	ADP
admet-535	359	6	traditional	traditional	ADJ
admet-535	359	7	chinese	chinese	ADJ
admet-535	359	8	medicines	medicine	NOUN
admet-535	359	9	using	use	VERB
admet-535	359	10	cell	cell	NOUN
admet-535	359	11	membrane	membrane	NOUN
admet-535	359	12	chromatography	chromatography	NOUN
admet-535	359	13	coupled	couple	VERB
admet-535	359	14	with	with	ADP
admet-535	359	15	mass	mass	ADJ
admet-535	359	16	spectrometry	spectrometry	NOUN
admet-535	359	17	.	.	PUNCT
admet-535	360	1	phytochem	phytochem	PROPN
admet-535	360	2	anal	anal	NOUN
admet-535	360	3	(	(	PUNCT
admet-535	360	4	2018	2018	NUM
admet-535	360	5	)	)	PUNCT
admet-535	360	6	.	.	PUNCT
admet-535	361	1	cayman	cayman	PROPN
admet-535	361	2	,	,	PUNCT
admet-535	361	3	omri	omri	PROPN
admet-535	361	4	&	&	CCONJ
admet-535	361	5	ciesla	ciesla	PROPN
admet-535	361	6	admet	admet	PROPN
admet-535	361	7	&	&	CCONJ
admet-535	361	8	dmpk	dmpk	PROPN
admet-535	361	9	6(3	6(3	PROPN
admet-535	361	10	)	)	PUNCT
admet-535	361	11	(	(	PUNCT
admet-535	361	12	2018	2018	NUM
admet-535	361	13	)	)	PUNCT
admet-535	361	14	200	200	NUM
admet-535	361	15	-	-	SYM
admet-535	361	16	214	214	NUM
admet-535	361	17	214	214	NUM
admet-535	362	1	[	[	X
admet-535	362	2	43	43	NUM
admet-535	362	3	]	]	X
admet-535	362	4	y.	y.	PROPN
admet-535	362	5	lin	lin	PROPN
admet-535	362	6	,	,	PUNCT
admet-535	362	7	c.	c.	PROPN
admet-535	362	8	wang	wang	PROPN
admet-535	362	9	,	,	PUNCT
admet-535	362	10	y.	y.	PROPN
admet-535	362	11	hou	hou	PROPN
admet-535	362	12	,	,	PUNCT
admet-535	362	13	w.	w.	PROPN
admet-535	362	14	sun	sun	PROPN
admet-535	362	15	,	,	PUNCT
admet-535	362	16	d.	d.	PROPN
admet-535	362	17	che	che	PROPN
admet-535	362	18	,	,	PUNCT
admet-535	362	19	l.	l.	PROPN
admet-535	362	20	yang	yang	PROPN
admet-535	362	21	,	,	PUNCT
admet-535	362	22	t.	t.	PROPN
admet-535	362	23	zhang	zhang	PROPN
admet-535	362	24	,	,	PUNCT
admet-535	362	25	m.	m.	NOUN
admet-535	362	26	sun	sun	PROPN
admet-535	362	27	,	,	PUNCT
admet-535	362	28	h.	h.	PROPN
admet-535	362	29	hehe	hehe	PROPN
admet-535	362	30	,	,	PUNCT
admet-535	362	31	l.	l.	PROPN
admet-535	362	32	he	he	PRON
admet-535	362	33	.	.	PUNCT
admet-535	363	1	simultaneous	simultaneous	ADJ
admet-535	363	2	identification	identification	NOUN
admet-535	363	3	of	of	ADP
admet-535	363	4	three	three	NUM
admet-535	363	5	pseudo	pseudo	NOUN
admet-535	363	6	-	-	ADJ
admet-535	363	7	allergic	allergic	ADJ
admet-535	363	8	components	component	NOUN
admet-535	363	9	in	in	ADP
admet-535	363	10	danshen	danshen	ADJ
admet-535	363	11	injection	injection	NOUN
admet-535	363	12	by	by	ADP
admet-535	363	13	using	use	VERB
admet-535	363	14	high	high	ADJ
admet-535	363	15	-	-	PUNCT
admet-535	363	16	expression	expression	NOUN
admet-535	363	17	mas	mas	NOUN
admet-535	363	18	-	-	PUNCT
admet-535	363	19	related	relate	VERB
admet-535	363	20	g	g	NOUN
admet-535	363	21	protein	protein	NOUN
admet-535	363	22	coupled	couple	VERB
admet-535	363	23	receptor	receptor	NOUN
admet-535	363	24	x2	x2	PROPN
admet-535	363	25	cell	cell	NOUN
admet-535	363	26	membrane	membrane	NOUN
admet-535	363	27	chromatography	chromatography	NOUN
admet-535	363	28	coupled	couple	VERB
admet-535	363	29	online	online	ADV
admet-535	363	30	to	to	ADP
admet-535	363	31	hplcesi	hplcesi	PROPN
admet-535	363	32	-	-	PUNCT
admet-535	363	33	ms	ms	PROPN
admet-535	363	34	/	/	SYM
admet-535	363	35	ms	ms	PROPN
admet-535	363	36	.	.	PROPN
admet-535	363	37	j	j	PROPN
admet-535	363	38	sep	sep	PROPN
admet-535	363	39	sci	sci	PROPN
admet-535	363	40	(	(	PUNCT
admet-535	363	41	2018	2018	NUM
admet-535	363	42	)	)	PUNCT
admet-535	363	43	.	.	PUNCT
admet-535	364	1	[	[	X
admet-535	364	2	44	44	NUM
admet-535	364	3	]	]	X
admet-535	364	4	k.l	k.l	PROPN
admet-535	364	5	.	.	PROPN
admet-535	364	6	habicht	habicht	PROPN
admet-535	364	7	,	,	PUNCT
admet-535	364	8	n.s	n.s	PROPN
admet-535	364	9	.	.	PROPN
admet-535	364	10	singh	singh	PROPN
admet-535	364	11	,	,	PUNCT
admet-535	364	12	f.e	f.e	PROPN
admet-535	364	13	.	.	PROPN
admet-535	364	14	indig	indig	PROPN
admet-535	364	15	,	,	PUNCT
admet-535	364	16	i.w	i.w	PROPN
admet-535	364	17	.	.	PROPN
admet-535	364	18	wainer	wainer	PROPN
admet-535	364	19	,	,	PUNCT
admet-535	364	20	r.	r.	PROPN
admet-535	364	21	moaddel	moaddel	PROPN
admet-535	364	22	,	,	PUNCT
admet-535	364	23	r.	r.	NOUN
admet-535	364	24	shimmo	shimmo	NOUN
admet-535	364	25	.	.	PUNCT
admet-535	365	1	the	the	DET
admet-535	365	2	development	development	NOUN
admet-535	365	3	of	of	ADP
admet-535	365	4	mitochondrial	mitochondrial	ADJ
admet-535	365	5	membrane	membrane	NOUN
admet-535	365	6	affinity	affinity	NOUN
admet-535	365	7	chromatography	chromatography	NOUN
admet-535	365	8	columns	column	NOUN
admet-535	365	9	for	for	ADP
admet-535	365	10	the	the	DET
admet-535	365	11	study	study	NOUN
admet-535	365	12	of	of	ADP
admet-535	365	13	mitochondrial	mitochondrial	ADJ
admet-535	365	14	transmembrane	transmembrane	ADJ
admet-535	365	15	proteins	protein	NOUN
admet-535	365	16	.	.	PUNCT
admet-535	366	1	anal	anal	ADJ
admet-535	366	2	biochem	biochem	NOUN
admet-535	366	3	484	484	NUM
admet-535	366	4	(	(	PUNCT
admet-535	366	5	2015	2015	NUM
admet-535	366	6	)	)	PUNCT
admet-535	366	7	154	154	NUM
admet-535	366	8	-	-	SYM
admet-535	366	9	161	161	NUM
admet-535	366	10	.	.	PUNCT
admet-535	367	1	[	[	X
admet-535	367	2	45	45	NUM
admet-535	367	3	]	]	X
admet-535	367	4	e.s	e.s	PROPN
admet-535	367	5	.	.	PROPN
admet-535	367	6	ng	ng	PROPN
admet-535	367	7	,	,	PUNCT
admet-535	367	8	n.w	n.w	PROPN
admet-535	367	9	.	.	PROPN
admet-535	367	10	chan	chan	PROPN
admet-535	367	11	,	,	PUNCT
admet-535	367	12	d.f	d.f	PROPN
admet-535	367	13	.	.	PROPN
admet-535	367	14	lewis	lewis	PROPN
admet-535	367	15	,	,	PUNCT
admet-535	367	16	o.	o.	PROPN
admet-535	367	17	hindsgaul	hindsgaul	PROPN
admet-535	367	18	,	,	PUNCT
admet-535	367	19	d.c	d.c	PROPN
admet-535	367	20	.	.	PUNCT
admet-535	367	21	schriemer	schriemer	PROPN
admet-535	367	22	.	.	PUNCT
admet-535	368	1	frontal	frontal	ADJ
admet-535	368	2	affinity	affinity	NOUN
admet-535	368	3	chromatography	chromatography	NOUN
admet-535	368	4	-	-	PUNCT
admet-535	368	5	mass	mass	NOUN
admet-535	368	6	spectrometry	spectrometry	NOUN
admet-535	368	7	.	.	PUNCT
admet-535	369	1	nat	nat	PROPN
admet-535	369	2	protoc	protoc	VERB
admet-535	369	3	2	2	NUM
admet-535	369	4	(	(	PUNCT
admet-535	369	5	2007	2007	NUM
admet-535	369	6	)	)	PUNCT
admet-535	369	7	1907	1907	NUM
admet-535	369	8	-	-	SYM
admet-535	369	9	1917	1917	NUM
admet-535	369	10	.	.	PUNCT
admet-535	370	1	[	[	X
admet-535	370	2	46	46	NUM
admet-535	370	3	]	]	PUNCT
admet-535	370	4	a.	a.	NOUN
admet-535	370	5	maciuk	maciuk	PROPN
admet-535	370	6	,	,	PUNCT
admet-535	370	7	r.	r.	PROPN
admet-535	370	8	moaddel	moaddel	PROPN
admet-535	370	9	,	,	PUNCT
admet-535	370	10	j.	j.	PROPN
admet-535	370	11	haginaka	haginaka	PROPN
admet-535	370	12	,	,	PUNCT
admet-535	370	13	i.w	i.w	PROPN
admet-535	370	14	.	.	PROPN
admet-535	370	15	wainer	wainer	PROPN
admet-535	370	16	.	.	PUNCT
admet-535	371	1	screening	screen	VERB
admet-535	371	2	of	of	ADP
admet-535	371	3	tobacco	tobacco	NOUN
admet-535	371	4	smoke	smoke	NOUN
admet-535	371	5	condensate	condensate	NOUN
admet-535	371	6	for	for	ADP
admet-535	371	7	nicotinic	nicotinic	ADJ
admet-535	371	8	acetylcholine	acetylcholine	NOUN
admet-535	371	9	receptor	receptor	NOUN
admet-535	371	10	ligands	ligand	NOUN
admet-535	371	11	using	use	VERB
admet-535	371	12	cellular	cellular	ADJ
admet-535	371	13	membrane	membrane	NOUN
admet-535	371	14	affinity	affinity	NOUN
admet-535	371	15	chromatography	chromatography	NOUN
admet-535	371	16	columns	column	NOUN
admet-535	371	17	and	and	CCONJ
admet-535	371	18	missing	miss	VERB
admet-535	371	19	peak	peak	NOUN
admet-535	371	20	chromatography	chromatography	NOUN
admet-535	371	21	.	.	PUNCT
admet-535	372	1	j	j	PROPN
admet-535	372	2	pharm	pharm	PROPN
admet-535	372	3	biomed	biome	VERB
admet-535	372	4	anal	anal	ADJ
admet-535	372	5	48	48	NUM
admet-535	372	6	(	(	PUNCT
admet-535	372	7	2008	2008	NUM
admet-535	372	8	)	)	PUNCT
admet-535	372	9	238	238	NUM
admet-535	372	10	-	-	SYM
admet-535	372	11	246	246	NUM
admet-535	372	12	.	.	PUNCT
admet-535	373	1	[	[	X
admet-535	373	2	47	47	NUM
admet-535	373	3	]	]	X
admet-535	373	4	k.s	k.s	PROPN
admet-535	373	5	.	.	PROPN
admet-535	373	6	dossou	dossou	PROPN
admet-535	373	7	,	,	PUNCT
admet-535	373	8	k.p	k.p	PROPN
admet-535	373	9	.	.	PROPN
admet-535	373	10	devkota	devkota	PROPN
admet-535	373	11	,	,	PUNCT
admet-535	373	12	c.	c.	PROPN
admet-535	373	13	morton	morton	PROPN
admet-535	373	14	,	,	PUNCT
admet-535	373	15	j.m	j.m	PROPN
admet-535	373	16	.	.	PROPN
admet-535	373	17	egan	egan	PROPN
admet-535	373	18	,	,	PUNCT
admet-535	373	19	g.	g.	PROPN
admet-535	373	20	lu	lu	PROPN
admet-535	373	21	,	,	PUNCT
admet-535	373	22	j.a	j.a	PROPN
admet-535	373	23	.	.	PROPN
admet-535	373	24	beutler	beutler	PROPN
admet-535	373	25	,	,	PUNCT
admet-535	373	26	r.	r.	PROPN
admet-535	373	27	moaddel	moaddel	PROPN
admet-535	373	28	.	.	PUNCT
admet-535	374	1	identification	identification	NOUN
admet-535	374	2	of	of	ADP
admet-535	374	3	cb1	cb1	PROPN
admet-535	374	4	/	/	SYM
admet-535	374	5	cb2	cb2	PROPN
admet-535	374	6	ligands	ligand	NOUN
admet-535	374	7	from	from	ADP
admet-535	374	8	zanthoxylum	zanthoxylum	ADJ
admet-535	374	9	bungeanum	bungeanum	NOUN
admet-535	374	10	.	.	PUNCT
admet-535	375	1	j	j	PROPN
admet-535	375	2	nat	nat	PROPN
admet-535	375	3	prod	prod	NOUN
admet-535	375	4	76	76	NUM
admet-535	375	5	(	(	PUNCT
admet-535	375	6	2013	2013	NUM
admet-535	375	7	)	)	PUNCT
admet-535	375	8	2060	2060	NUM
admet-535	375	9	-	-	SYM
admet-535	375	10	2064	2064	NUM
admet-535	375	11	.	.	PUNCT
admet-535	376	1	[	[	X
admet-535	376	2	48	48	NUM
admet-535	376	3	]	]	X
admet-535	376	4	m.p	m.p	PROPN
admet-535	376	5	.	.	PROPN
admet-535	376	6	mattson	mattson	PROPN
admet-535	376	7	,	,	PUNCT
admet-535	376	8	k.	k.	PROPN
admet-535	376	9	moehl	moehl	PROPN
admet-535	376	10	,	,	PUNCT
admet-535	376	11	n.	n.	NOUN
admet-535	376	12	ghena	ghena	PROPN
admet-535	376	13	,	,	PUNCT
admet-535	376	14	m.	m.	NOUN
admet-535	376	15	schmaedick	schmaedick	PROPN
admet-535	376	16	,	,	PUNCT
admet-535	376	17	a.	a.	PROPN
admet-535	376	18	cheng	cheng	PROPN
admet-535	376	19	.	.	PUNCT
admet-535	377	1	intermittent	intermittent	PROPN
admet-535	377	2	metabolic	metabolic	NOUN
admet-535	377	3	switching	switching	NOUN
admet-535	377	4	,	,	PUNCT
admet-535	377	5	neuroplasticity	neuroplasticity	NOUN
admet-535	377	6	and	and	CCONJ
admet-535	377	7	brain	brain	NOUN
admet-535	377	8	health	health	NOUN
admet-535	377	9	.	.	PUNCT
admet-535	378	1	nat	nat	PROPN
admet-535	378	2	rev	rev	PROPN
admet-535	378	3	neurosci	neurosci	PROPN
admet-535	378	4	19	19	NUM
admet-535	378	5	(	(	PUNCT
admet-535	378	6	2018	2018	NUM
admet-535	378	7	)	)	PUNCT
admet-535	378	8	63	63	NUM
admet-535	378	9	-	-	SYM
admet-535	378	10	80	80	NUM
admet-535	378	11	.	.	PUNCT
admet-535	379	1	©	©	PROPN
admet-535	379	2	2018	2018	NUM
admet-535	379	3	by	by	ADP
admet-535	379	4	the	the	DET
admet-535	379	5	authors	author	NOUN
admet-535	379	6	;	;	PUNCT
admet-535	380	1	licensee	licensee	PROPN
admet-535	380	2	iapc	iapc	PROPN
admet-535	380	3	,	,	PUNCT
admet-535	380	4	zagreb	zagreb	PROPN
admet-535	380	5	,	,	PUNCT
admet-535	380	6	croatia	croatia	PROPN
admet-535	380	7	.	.	PUNCT
admet-535	381	1	this	this	DET
admet-535	381	2	article	article	NOUN
admet-535	381	3	is	be	AUX
admet-535	381	4	an	an	DET
admet-535	381	5	open	open	ADJ
admet-535	381	6	-	-	PUNCT
admet-535	381	7	access	access	NOUN
admet-535	381	8	article	article	NOUN
admet-535	381	9	distributed	distribute	VERB
admet-535	381	10	under	under	ADP
admet-535	381	11	the	the	DET
admet-535	381	12	terms	term	NOUN
admet-535	381	13	and	and	CCONJ
admet-535	381	14	conditions	condition	NOUN
admet-535	381	15	of	of	ADP
admet-535	381	16	the	the	DET
admet-535	381	17	creative	creative	ADJ
admet-535	381	18	commons	common	NOUN
admet-535	381	19	attribution	attribution	NOUN
admet-535	381	20	license	license	NOUN
admet-535	381	21	(	(	PUNCT
admet-535	381	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-535	381	23	)	)	PUNCT
admet-535	381	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN