id	sid	tid	token	lemma	pos
admet-544	1	1	application	application	NOUN
admet-544	1	2	of	of	ADP
admet-544	1	3	biomimetic	biomimetic	ADJ
admet-544	1	4	hplc	hplc	NOUN
admet-544	1	5	to	to	PART
admet-544	1	6	estimate	estimate	VERB
admet-544	1	7	lipophilicity	lipophilicity	NOUN
admet-544	1	8	,	,	PUNCT
admet-544	1	9	protein	protein	NOUN
admet-544	1	10	and	and	CCONJ
admet-544	1	11	phospholipid	phospholipid	NOUN
admet-544	1	12	binding	bind	VERB
admet-544	1	13	of	of	ADP
admet-544	1	14	potential	potential	ADJ
admet-544	1	15	peptide	peptide	NOUN
admet-544	1	16	therapeutics	therapeutic	NOUN
admet-544	1	17	doi	doi	NOUN
admet-544	1	18	:	:	PUNCT
admet-544	1	19	10.5599	10.5599	NUM
admet-544	1	20	/	/	SYM
admet-544	1	21	admet.544	admet.544	PROPN
admet-544	1	22	162	162	NUM
admet-544	1	23	admet	admet	X
admet-544	1	24	&	&	CCONJ
admet-544	1	25	dmpk	dmpk	PROPN
admet-544	1	26	6(2	6(2	NUM
admet-544	1	27	)	)	PUNCT
admet-544	1	28	(	(	PUNCT
admet-544	1	29	2018	2018	NUM
admet-544	1	30	)	)	PUNCT
admet-544	1	31	162	162	NUM
admet-544	1	32	-	-	SYM
admet-544	1	33	175	175	NUM
admet-544	1	34	;	;	PUNCT
admet-544	1	35	doi	doi	NOUN
admet-544	1	36	:	:	PUNCT
admet-544	1	37	http://dx.doi.org/10.5599/admet.544	http://dx.doi.org/10.5599/admet.544	VERB
admet-544	1	38	open	open	ADJ
admet-544	1	39	access	access	NOUN
admet-544	1	40	:	:	PUNCT
admet-544	1	41	issn	issn	PROPN
admet-544	1	42	:	:	PUNCT
admet-544	1	43	1848	1848	NUM
admet-544	1	44	-	-	SYM
admet-544	1	45	7718	7718	NUM
admet-544	1	46	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-544	1	47	original	original	ADJ
admet-544	1	48	scientific	scientific	ADJ
admet-544	1	49	paper	paper	NOUN
admet-544	1	50	application	application	NOUN
admet-544	1	51	of	of	ADP
admet-544	1	52	biomimetic	biomimetic	ADJ
admet-544	1	53	hplc	hplc	NOUN
admet-544	1	54	to	to	PART
admet-544	1	55	estimate	estimate	VERB
admet-544	1	56	lipophilicity	lipophilicity	NOUN
admet-544	1	57	,	,	PUNCT
admet-544	1	58	protein	protein	NOUN
admet-544	1	59	and	and	CCONJ
admet-544	1	60	phospholipid	phospholipid	NOUN
admet-544	1	61	binding	bind	VERB
admet-544	1	62	of	of	ADP
admet-544	1	63	potential	potential	ADJ
admet-544	1	64	peptide	peptide	NOUN
admet-544	1	65	therapeutics	therapeutic	NOUN
admet-544	1	66	klara	klara	PROPN
admet-544	1	67	valko*1,2	valko*1,2	PROPN
admet-544	1	68	,	,	PUNCT
admet-544	1	69	gabriela	gabriela	PROPN
admet-544	1	70	ivanova	ivanova	PROPN
admet-544	1	71	-	-	PUNCT
admet-544	1	72	berndt3	berndt3	PROPN
admet-544	1	73	,	,	PUNCT
admet-544	1	74	paul	paul	PROPN
admet-544	1	75	beswick3	beswick3	PROPN
admet-544	1	76	,	,	PUNCT
admet-544	1	77	mark	mark	PROPN
admet-544	1	78	kindey4,5	kindey4,5	PROPN
admet-544	1	79	,	,	PUNCT
admet-544	1	80	dorothy	dorothy	PROPN
admet-544	1	81	ko6	ko6	PROPN
admet-544	1	82	1	1	NUM
admet-544	1	83	bio	bio	ADJ
admet-544	1	84	-	-	ADJ
admet-544	1	85	mimetic	mimetic	ADJ
admet-544	1	86	chromatography	chromatography	PROPN
admet-544	1	87	ltd	ltd	PROPN
admet-544	1	88	,	,	PUNCT
admet-544	1	89	business	business	PROPN
admet-544	1	90	&	&	CCONJ
admet-544	1	91	technology	technology	PROPN
admet-544	1	92	centre	centre	PROPN
admet-544	1	93	,	,	PUNCT
admet-544	1	94	stevenage	stevenage	PROPN
admet-544	1	95	,	,	PUNCT
admet-544	1	96	sg1	sg1	PROPN
admet-544	1	97	2dx	2dx	PROPN
admet-544	1	98	united	united	PROPN
admet-544	1	99	kingdom	kingdom	PROPN
admet-544	1	100	2	2	NUM
admet-544	1	101	department	department	NOUN
admet-544	1	102	of	of	ADP
admet-544	1	103	biological	biological	ADJ
admet-544	1	104	and	and	CCONJ
admet-544	1	105	pharmaceutical	pharmaceutical	NOUN
admet-544	1	106	chemistry	chemistry	NOUN
admet-544	1	107	,	,	PUNCT
admet-544	1	108	ucl	ucl	VERB
admet-544	1	109	school	school	NOUN
admet-544	1	110	of	of	ADP
admet-544	1	111	pharmacy	pharmacy	NOUN
admet-544	1	112	london	london	PROPN
admet-544	1	113	wc1n	wc1n	PROPN
admet-544	1	114	1ax	1ax	ADJ
admet-544	1	115	united	united	ADJ
admet-544	1	116	kingdom	kingdom	PROPN
admet-544	1	117	3	3	NUM
admet-544	1	118	bicycle	bicycle	NOUN
admet-544	1	119	therapeutics	therapeutics	PROPN
admet-544	1	120	ltd	ltd	PROPN
admet-544	1	121	,	,	PUNCT
admet-544	1	122	cambridge	cambridge	PROPN
admet-544	1	123	,	,	PUNCT
admet-544	1	124	united	united	PROPN
admet-544	1	125	kingdom	kingdom	PROPN
admet-544	1	126	4	4	NUM
admet-544	1	127	department	department	NOUN
admet-544	1	128	of	of	ADP
admet-544	1	129	pharmaceutical	pharmaceutical	NOUN
admet-544	1	130	sciences	science	NOUN
admet-544	1	131	,	,	PUNCT
admet-544	1	132	college	college	NOUN
admet-544	1	133	of	of	ADP
admet-544	1	134	pharmacy	pharmacy	NOUN
admet-544	1	135	,	,	PUNCT
admet-544	1	136	university	university	NOUN
admet-544	1	137	of	of	ADP
admet-544	1	138	south	south	PROPN
admet-544	1	139	florida	florida	PROPN
admet-544	1	140	,	,	PUNCT
admet-544	1	141	tampa	tampa	PROPN
admet-544	1	142	,	,	PUNCT
admet-544	1	143	fl	fl	PROPN
admet-544	1	144	,	,	PUNCT
admet-544	1	145	usa	usa	PROPN
admet-544	1	146	5	5	NUM
admet-544	1	147	james	james	PROPN
admet-544	1	148	a.	a.	PROPN
admet-544	1	149	haley	haley	PROPN
admet-544	1	150	vamc	vamc	PROPN
admet-544	1	151	,	,	PUNCT
admet-544	1	152	tampa	tampa	PROPN
admet-544	1	153	,	,	PUNCT
admet-544	1	154	fl	fl	PROPN
admet-544	1	155	,	,	PUNCT
admet-544	1	156	usa	usa	PROPN
admet-544	1	157	6	6	NUM
admet-544	1	158	genervon	genervon	PROPN
admet-544	1	159	biopharmaceuticals	biopharmaceutical	NOUN
admet-544	1	160	llc	llc	PROPN
admet-544	1	161	,	,	PUNCT
admet-544	1	162	pasadena	pasadena	PROPN
admet-544	1	163	,	,	PUNCT
admet-544	1	164	ca	ca	PROPN
admet-544	1	165	,	,	PUNCT
admet-544	1	166	usa	usa	PROPN
admet-544	1	167	*	*	PUNCT
admet-544	1	168	corresponding	correspond	VERB
admet-544	1	169	author	author	NOUN
admet-544	1	170	:	:	PUNCT
admet-544	1	171	e	e	NOUN
admet-544	1	172	-	-	NOUN
admet-544	1	173	mail	mail	NOUN
admet-544	1	174	:	:	PUNCT
admet-544	1	175	klara_valko@bio-mimetic-chromatography.com	klara_valko@bio-mimetic-chromatography.com	NOUN
admet-544	1	176	;	;	PUNCT
admet-544	1	177	tel	tel	PROPN
admet-544	1	178	.	.	PUNCT
admet-544	1	179	:	:	PUNCT
admet-544	1	180	+447521	+447521	NOUN
admet-544	1	181	989558	989558	NUM
admet-544	1	182	received	receive	VERB
admet-544	1	183	:	:	PUNCT
admet-544	1	184	april	april	PROPN
admet-544	1	185	27	27	NUM
admet-544	1	186	,	,	PUNCT
admet-544	1	187	2018	2018	NUM
admet-544	1	188	;	;	PUNCT
admet-544	1	189	revised	revise	VERB
admet-544	1	190	:	:	PUNCT
admet-544	1	191	may	may	AUX
admet-544	1	192	28	28	NUM
admet-544	1	193	,	,	PUNCT
admet-544	1	194	2018	2018	NUM
admet-544	1	195	;	;	PUNCT
admet-544	1	196	published	publish	VERB
admet-544	1	197	:	:	PUNCT
admet-544	1	198	june	june	PROPN
admet-544	1	199	06	06	NUM
admet-544	1	200	,	,	PUNCT
admet-544	1	201	2018	2018	NUM
admet-544	1	202	abstract	abstract	ADJ
admet-544	1	203	peptide	peptide	NOUN
admet-544	1	204	therapeutics	therapeutic	NOUN
admet-544	1	205	are	be	AUX
admet-544	1	206	new	new	ADJ
admet-544	1	207	modalities	modality	NOUN
admet-544	1	208	offering	offer	VERB
admet-544	1	209	several	several	ADJ
admet-544	1	210	challenges	challenge	NOUN
admet-544	1	211	to	to	ADP
admet-544	1	212	drug	drug	NOUN
admet-544	1	213	discovery	discovery	NOUN
admet-544	1	214	.	.	PUNCT
admet-544	2	1	they	they	PRON
admet-544	2	2	are	be	AUX
admet-544	2	3	generally	generally	ADV
admet-544	2	4	less	less	ADV
admet-544	2	5	stable	stable	ADJ
admet-544	2	6	and	and	CCONJ
admet-544	2	7	permeable	permeable	ADJ
admet-544	2	8	in	in	ADP
admet-544	2	9	vivo	vivo	NOUN
admet-544	2	10	.	.	PUNCT
admet-544	3	1	the	the	DET
admet-544	3	2	characterization	characterization	NOUN
admet-544	3	3	of	of	ADP
admet-544	3	4	their	their	PRON
admet-544	3	5	lipophilicity	lipophilicity	NOUN
admet-544	3	6	can	can	AUX
admet-544	3	7	not	not	PART
admet-544	3	8	be	be	AUX
admet-544	3	9	carried	carry	VERB
admet-544	3	10	out	out	ADP
admet-544	3	11	using	use	VERB
admet-544	3	12	the	the	DET
admet-544	3	13	traditional	traditional	ADJ
admet-544	3	14	in	in	ADP
admet-544	3	15	silico	silico	NOUN
admet-544	3	16	or	or	CCONJ
admet-544	3	17	wet	wet	ADJ
admet-544	3	18	octanol	octanol	NOUN
admet-544	3	19	/	/	SYM
admet-544	3	20	water	water	NOUN
admet-544	3	21	partition	partition	NOUN
admet-544	3	22	coefficients	coefficient	NOUN
admet-544	3	23	.	.	PUNCT
admet-544	4	1	the	the	DET
admet-544	4	2	prediction	prediction	NOUN
admet-544	4	3	of	of	ADP
admet-544	4	4	their	their	PRON
admet-544	4	5	in	in	ADP
admet-544	4	6	vivo	vivo	ADJ
admet-544	4	7	distribution	distribution	NOUN
admet-544	4	8	and	and	CCONJ
admet-544	4	9	permeability	permeability	NOUN
admet-544	4	10	is	be	AUX
admet-544	4	11	also	also	ADV
admet-544	4	12	challenging	challenge	VERB
admet-544	4	13	.	.	PUNCT
admet-544	5	1	in	in	ADP
admet-544	5	2	this	this	DET
admet-544	5	3	paper	paper	NOUN
admet-544	5	4	,	,	PUNCT
admet-544	5	5	it	it	PRON
admet-544	5	6	is	be	AUX
admet-544	5	7	demonstrated	demonstrate	VERB
admet-544	5	8	that	that	SCONJ
admet-544	5	9	the	the	DET
admet-544	5	10	biomimetic	biomimetic	ADJ
admet-544	5	11	properties	property	NOUN
admet-544	5	12	such	such	ADJ
admet-544	5	13	as	as	ADP
admet-544	5	14	lipophilicity	lipophilicity	NOUN
admet-544	5	15	,	,	PUNCT
admet-544	5	16	protein	protein	NOUN
admet-544	5	17	and	and	CCONJ
admet-544	5	18	phospholipid	phospholipid	NOUN
admet-544	5	19	binding	bind	VERB
admet-544	5	20	can	can	AUX
admet-544	5	21	be	be	AUX
admet-544	5	22	easily	easily	ADV
admet-544	5	23	assessed	assess	VERB
admet-544	5	24	by	by	ADP
admet-544	5	25	hplc	hplc	NOUN
admet-544	5	26	using	use	VERB
admet-544	5	27	chemically	chemically	ADV
admet-544	5	28	bonded	bond	VERB
admet-544	5	29	protein	protein	NOUN
admet-544	5	30	and	and	CCONJ
admet-544	5	31	immobilized	immobilize	VERB
admet-544	5	32	artificial	artificial	ADJ
admet-544	5	33	membrane	membrane	NOUN
admet-544	5	34	(	(	PUNCT
admet-544	5	35	iam	iam	PROPN
admet-544	5	36	)	)	PUNCT
admet-544	5	37	stationary	stationary	ADJ
admet-544	5	38	phases	phase	NOUN
admet-544	5	39	.	.	PUNCT
admet-544	6	1	the	the	DET
admet-544	6	2	obtained	obtain	VERB
admet-544	6	3	properties	property	NOUN
admet-544	6	4	for	for	ADP
admet-544	6	5	a	a	DET
admet-544	6	6	set	set	NOUN
admet-544	6	7	of	of	ADP
admet-544	6	8	potential	potential	ADJ
admet-544	6	9	therapeutic	therapeutic	ADJ
admet-544	6	10	peptides	peptide	NOUN
admet-544	6	11	with	with	ADP
admet-544	6	12	3	3	NUM
admet-544	6	13	to	to	PART
admet-544	6	14	33	33	NUM
admet-544	6	15	amino	amino	NOUN
admet-544	6	16	acids	acid	NOUN
admet-544	6	17	have	have	AUX
admet-544	6	18	been	be	AUX
admet-544	6	19	analysed	analyse	VERB
admet-544	6	20	and	and	CCONJ
admet-544	6	21	it	it	PRON
admet-544	6	22	was	be	AUX
admet-544	6	23	found	find	VERB
admet-544	6	24	that	that	SCONJ
admet-544	6	25	similar	similar	ADJ
admet-544	6	26	characteristics	characteristic	NOUN
admet-544	6	27	of	of	ADP
admet-544	6	28	the	the	DET
admet-544	6	29	properties	property	NOUN
admet-544	6	30	could	could	AUX
admet-544	6	31	be	be	AUX
admet-544	6	32	observed	observe	VERB
admet-544	6	33	as	as	ADP
admet-544	6	34	for	for	ADP
admet-544	6	35	small	small	ADJ
admet-544	6	36	molecule	molecule	NOUN
admet-544	6	37	drugs	drug	NOUN
admet-544	6	38	.	.	PUNCT
admet-544	7	1	the	the	DET
admet-544	7	2	albumin	albumin	ADJ
admet-544	7	3	binding	binding	NOUN
admet-544	7	4	showed	show	VERB
admet-544	7	5	correlation	correlation	NOUN
admet-544	7	6	with	with	ADP
admet-544	7	7	their	their	PRON
admet-544	7	8	measured	measure	VERB
admet-544	7	9	lipophilicity	lipophilicity	NOUN
admet-544	7	10	on	on	ADP
admet-544	7	11	the	the	DET
admet-544	7	12	c-18	c-18	PROPN
admet-544	7	13	stationary	stationary	ADJ
admet-544	7	14	phase	phase	NOUN
admet-544	7	15	with	with	ADP
admet-544	7	16	acidic	acidic	ADJ
admet-544	7	17	peptides	peptide	NOUN
admet-544	7	18	showing	show	VERB
admet-544	7	19	stronger	strong	ADJ
admet-544	7	20	than	than	SCONJ
admet-544	7	21	expected	expect	VERB
admet-544	7	22	albumin	albumin	ADJ
admet-544	7	23	binding	binding	NOUN
admet-544	7	24	.	.	PUNCT
admet-544	8	1	the	the	DET
admet-544	8	2	(	(	PUNCT
admet-544	8	3	iam	iam	PROPN
admet-544	8	4	)	)	PUNCT
admet-544	8	5	chromatography	chromatography	NOUN
admet-544	8	6	revealed	reveal	VERB
admet-544	8	7	peptide	peptide	ADJ
admet-544	8	8	membrane	membrane	NOUN
admet-544	8	9	affinity	affinity	NOUN
admet-544	8	10	,	,	PUNCT
admet-544	8	11	which	which	PRON
admet-544	8	12	was	be	AUX
admet-544	8	13	stronger	strong	ADJ
admet-544	8	14	for	for	ADP
admet-544	8	15	positively	positively	ADV
admet-544	8	16	charged	charge	VERB
admet-544	8	17	peptides	peptide	NOUN
admet-544	8	18	(	(	PUNCT
admet-544	8	19	containing	contain	VERB
admet-544	8	20	arginine	arginine	NOUN
admet-544	8	21	)	)	PUNCT
admet-544	8	22	and	and	CCONJ
admet-544	8	23	showed	show	VERB
admet-544	8	24	correlation	correlation	NOUN
admet-544	8	25	to	to	ADP
admet-544	8	26	the	the	DET
admet-544	8	27	alpha-1	alpha-1	NOUN
admet-544	8	28	-	-	PUNCT
admet-544	8	29	acid	acid	NOUN
admet-544	8	30	glycoprotein	glycoprotein	NOUN
admet-544	8	31	(	(	PUNCT
admet-544	8	32	agp	agp	NOUN
admet-544	8	33	)	)	PUNCT
admet-544	8	34	binding	binding	NOUN
admet-544	8	35	,	,	PUNCT
admet-544	8	36	which	which	PRON
admet-544	8	37	was	be	AUX
admet-544	8	38	also	also	ADV
admet-544	8	39	stronger	strong	ADJ
admet-544	8	40	for	for	ADP
admet-544	8	41	positively	positively	ADV
admet-544	8	42	charged	charge	VERB
admet-544	8	43	compounds	compound	NOUN
admet-544	8	44	.	.	PUNCT
admet-544	9	1	the	the	DET
admet-544	9	2	in	in	ADP
admet-544	9	3	vivo	vivo	ADJ
admet-544	9	4	volume	volume	NOUN
admet-544	9	5	of	of	ADP
admet-544	9	6	distribution	distribution	NOUN
admet-544	9	7	and	and	CCONJ
admet-544	9	8	drug	drug	NOUN
admet-544	9	9	efficiency	efficiency	NOUN
admet-544	9	10	of	of	ADP
admet-544	9	11	the	the	DET
admet-544	9	12	peptides	peptide	NOUN
admet-544	9	13	have	have	AUX
admet-544	9	14	been	be	AUX
admet-544	9	15	estimated	estimate	VERB
admet-544	9	16	using	use	VERB
admet-544	9	17	the	the	DET
admet-544	9	18	models	model	NOUN
admet-544	9	19	developed	develop	VERB
admet-544	9	20	for	for	ADP
admet-544	9	21	small	small	ADJ
admet-544	9	22	molecules	molecule	NOUN
admet-544	9	23	.	.	PUNCT
admet-544	10	1	one	one	NUM
admet-544	10	2	of	of	ADP
admet-544	10	3	the	the	DET
admet-544	10	4	candidate	candidate	NOUN
admet-544	10	5	linear	linear	ADJ
admet-544	10	6	peptides	peptide	NOUN
admet-544	10	7	has	have	AUX
admet-544	10	8	been	be	AUX
admet-544	10	9	assessed	assess	VERB
admet-544	10	10	in	in	ADP
admet-544	10	11	various	various	ADJ
admet-544	10	12	cellular	cellular	NOUN
admet-544	10	13	and	and	CCONJ
admet-544	10	14	in	in	ADP
admet-544	10	15	vivo	vivo	ADJ
admet-544	10	16	assays	assay	NOUN
admet-544	10	17	and	and	CCONJ
admet-544	10	18	the	the	DET
admet-544	10	19	results	result	NOUN
admet-544	10	20	have	have	AUX
admet-544	10	21	confirmed	confirm	VERB
admet-544	10	22	the	the	DET
admet-544	10	23	estimated	estimate	VERB
admet-544	10	24	cell	cell	NOUN
admet-544	10	25	partition	partition	NOUN
admet-544	10	26	and	and	CCONJ
admet-544	10	27	brain	brain	NOUN
admet-544	10	28	to	to	ADP
admet-544	10	29	plasma	plasma	NOUN
admet-544	10	30	ratio	ratio	NOUN
admet-544	10	31	.	.	PUNCT
admet-544	11	1	it	it	PRON
admet-544	11	2	can	can	AUX
admet-544	11	3	be	be	AUX
admet-544	11	4	demonstrated	demonstrate	VERB
admet-544	11	5	,	,	PUNCT
admet-544	11	6	that	that	SCONJ
admet-544	11	7	up	up	ADP
admet-544	11	8	to	to	PART
admet-544	11	9	21	21	NUM
admet-544	11	10	amino	amino	NOUN
admet-544	11	11	acids	acid	NOUN
admet-544	11	12	,	,	PUNCT
admet-544	11	13	the	the	DET
admet-544	11	14	peaks	peak	NOUN
admet-544	11	15	of	of	ADP
admet-544	11	16	the	the	DET
admet-544	11	17	peptides	peptide	NOUN
admet-544	11	18	obtained	obtain	VERB
admet-544	11	19	on	on	ADP
admet-544	11	20	the	the	DET
admet-544	11	21	protein	protein	NOUN
admet-544	11	22	phase	phase	NOUN
admet-544	11	23	were	be	AUX
admet-544	11	24	symmetrical	symmetrical	ADJ
admet-544	11	25	and	and	CCONJ
admet-544	11	26	narrow	narrow	ADJ
admet-544	11	27	.	.	PUNCT
admet-544	12	1	the	the	DET
admet-544	12	2	interaction	interaction	NOUN
admet-544	12	3	of	of	ADP
admet-544	12	4	larger	large	ADJ
admet-544	12	5	peptides	peptide	NOUN
admet-544	12	6	with	with	ADP
admet-544	12	7	the	the	DET
admet-544	12	8	protein	protein	NOUN
admet-544	12	9	stationary	stationary	ADJ
admet-544	12	10	phases	phase	NOUN
admet-544	12	11	resulted	result	VERB
admet-544	12	12	in	in	ADP
admet-544	12	13	wide	wide	ADJ
admet-544	12	14	peaks	peak	NOUN
admet-544	12	15	showing	show	VERB
admet-544	12	16	multiple	multiple	ADJ
admet-544	12	17	equilibrium	equilibrium	NOUN
admet-544	12	18	processes	process	NOUN
admet-544	12	19	with	with	ADP
admet-544	12	20	slow	slow	ADJ
admet-544	12	21	kinetics	kinetic	NOUN
admet-544	12	22	during	during	ADP
admet-544	12	23	chromatography	chromatography	NOUN
admet-544	12	24	.	.	PUNCT
admet-544	13	1	the	the	DET
admet-544	13	2	larger	large	ADJ
admet-544	13	3	peptides	peptide	NOUN
admet-544	13	4	showed	show	VERB
admet-544	13	5	narrow	narrow	ADJ
admet-544	13	6	and	and	CCONJ
admet-544	13	7	symmetrical	symmetrical	ADJ
admet-544	13	8	peaks	peak	NOUN
admet-544	13	9	on	on	ADP
admet-544	13	10	the	the	DET
admet-544	13	11	iam	iam	PROPN
admet-544	13	12	column	column	NOUN
admet-544	13	13	enabling	enable	VERB
admet-544	13	14	the	the	DET
admet-544	13	15	quantification	quantification	NOUN
admet-544	13	16	of	of	ADP
admet-544	13	17	peptide	peptide	ADJ
admet-544	13	18	cell	cell	NOUN
admet-544	13	19	membrane	membrane	NOUN
admet-544	13	20	interactions	interaction	NOUN
admet-544	13	21	.	.	PUNCT
admet-544	14	1	keywords	keyword	NOUN
admet-544	14	2	human	human	ADJ
admet-544	14	3	serum	serum	NOUN
admet-544	14	4	albumin	albumin	PROPN
admet-544	14	5	binding	binding	NOUN
admet-544	14	6	;	;	PUNCT
admet-544	14	7	immobilized	immobilize	VERB
admet-544	14	8	artificial	artificial	ADJ
admet-544	14	9	membrane	membrane	NOUN
admet-544	14	10	;	;	PUNCT
admet-544	14	11	chromatography	chromatography	NOUN
admet-544	14	12	,	,	PUNCT
admet-544	14	13	peptides	peptide	NOUN
admet-544	14	14	,	,	PUNCT
admet-544	14	15	tissue	tissue	NOUN
admet-544	14	16	binding	bind	VERB
admet-544	14	17	,	,	PUNCT
admet-544	14	18	brain	brain	NOUN
admet-544	14	19	to	to	ADP
admet-544	14	20	plasma	plasma	NOUN
admet-544	14	21	ratio	ratio	PROPN
admet-544	14	22	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-544	14	23	mailto:klara_valko@bio-mimetic-chromatography.com	mailto:klara_valko@bio-mimetic-chromatography.com	PROPN
admet-544	14	24	admet	admet	PROPN
admet-544	14	25	&	&	CCONJ
admet-544	14	26	dmpk	dmpk	PROPN
admet-544	14	27	6(2	6(2	NUM
admet-544	14	28	)	)	PUNCT
admet-544	14	29	(	(	PUNCT
admet-544	14	30	2018	2018	NUM
admet-544	14	31	)	)	PUNCT
admet-544	14	32	162	162	NUM
admet-544	14	33	-	-	SYM
admet-544	14	34	175	175	NUM
admet-544	14	35	biomimetic	biomimetic	ADJ
admet-544	14	36	hplc	hplc	NOUN
admet-544	14	37	in	in	ADP
admet-544	14	38	the	the	DET
admet-544	14	39	estimation	estimation	NOUN
admet-544	14	40	of	of	ADP
admet-544	14	41	physchem	physchem	NOUN
admet-544	14	42	properties	property	NOUN
admet-544	14	43	of	of	ADP
admet-544	14	44	peptides	peptide	NOUN
admet-544	14	45	doi	doi	NOUN
admet-544	14	46	:	:	PUNCT
admet-544	14	47	10.5599	10.5599	NUM
admet-544	14	48	/	/	SYM
admet-544	14	49	admet.544	admet.544	PROPN
admet-544	14	50	163	163	NUM
admet-544	14	51	introduction	introduction	NOUN
admet-544	14	52	pharmaceutical	pharmaceutical	NOUN
admet-544	14	53	and	and	CCONJ
admet-544	14	54	drug	drug	NOUN
admet-544	14	55	discovery	discovery	NOUN
admet-544	14	56	companies	company	NOUN
admet-544	14	57	are	be	AUX
admet-544	14	58	searching	search	VERB
admet-544	14	59	for	for	ADP
admet-544	14	60	new	new	ADJ
admet-544	14	61	modalities	modality	NOUN
admet-544	14	62	outside	outside	ADP
admet-544	14	63	the	the	DET
admet-544	14	64	traditional	traditional	ADJ
admet-544	14	65	small	small	ADJ
admet-544	14	66	molecular	molecular	ADJ
admet-544	14	67	drug	drug	NOUN
admet-544	14	68	space	space	NOUN
admet-544	14	69	.	.	PUNCT
admet-544	15	1	peptides	peptide	NOUN
admet-544	15	2	,	,	PUNCT
admet-544	15	3	defined	define	VERB
admet-544	15	4	as	as	ADP
admet-544	15	5	having	have	VERB
admet-544	15	6	less	less	ADJ
admet-544	15	7	than	than	ADP
admet-544	15	8	50	50	NUM
admet-544	15	9	amino	amino	NOUN
admet-544	15	10	acids	acid	NOUN
admet-544	15	11	,	,	PUNCT
admet-544	15	12	have	have	AUX
admet-544	15	13	been	be	AUX
admet-544	15	14	long	long	ADV
admet-544	15	15	recognized	recognize	VERB
admet-544	15	16	as	as	ADP
admet-544	15	17	potential	potential	ADJ
admet-544	15	18	therapeutics	therapeutic	NOUN
admet-544	15	19	[	[	X
admet-544	15	20	1	1	NUM
admet-544	15	21	]	]	PUNCT
admet-544	15	22	.	.	PUNCT
admet-544	16	1	more	more	ADJ
admet-544	16	2	than	than	ADP
admet-544	16	3	140	140	NUM
admet-544	16	4	peptides	peptide	NOUN
admet-544	16	5	are	be	AUX
admet-544	16	6	now	now	ADV
admet-544	16	7	in	in	ADP
admet-544	16	8	clinical	clinical	ADJ
admet-544	16	9	trials	trial	NOUN
admet-544	16	10	and	and	CCONJ
admet-544	16	11	more	more	ADJ
admet-544	16	12	than	than	ADP
admet-544	16	13	60	60	NUM
admet-544	16	14	peptide	peptide	ADJ
admet-544	16	15	drugs	drug	NOUN
admet-544	16	16	have	have	AUX
admet-544	16	17	been	be	AUX
admet-544	16	18	approved	approve	VERB
admet-544	16	19	by	by	ADP
admet-544	16	20	fda	fda	PROPN
admet-544	17	1	[	[	X
admet-544	17	2	2	2	NUM
admet-544	17	3	]	]	PUNCT
admet-544	17	4	.	.	PUNCT
admet-544	18	1	the	the	DET
admet-544	18	2	therapeutic	therapeutic	ADJ
admet-544	18	3	area	area	NOUN
admet-544	18	4	ranges	range	VERB
admet-544	18	5	from	from	ADP
admet-544	18	6	antimicrobial	antimicrobial	ADJ
admet-544	18	7	to	to	ADP
admet-544	18	8	anticancer	anticancer	NOUN
admet-544	18	9	,	,	PUNCT
admet-544	18	10	but	but	CCONJ
admet-544	18	11	it	it	PRON
admet-544	18	12	is	be	AUX
admet-544	18	13	continuously	continuously	ADV
admet-544	18	14	expanding	expand	VERB
admet-544	18	15	to	to	ADP
admet-544	18	16	new	new	ADJ
admet-544	18	17	areas	area	NOUN
admet-544	18	18	such	such	ADJ
admet-544	18	19	as	as	ADP
admet-544	18	20	irritable	irritable	ADJ
admet-544	18	21	bowel	bowel	NOUN
admet-544	18	22	syndrome	syndrome	NOUN
admet-544	18	23	(	(	PUNCT
admet-544	18	24	linaclotide	linaclotide	ADV
admet-544	18	25	)	)	PUNCT
admet-544	18	26	,	,	PUNCT
admet-544	18	27	cushing	cushing	NOUN
admet-544	18	28	’s	’s	PART
admet-544	18	29	syndrome	syndrome	NOUN
admet-544	18	30	(	(	PUNCT
admet-544	18	31	pasireotide	pasireotide	NOUN
admet-544	18	32	)	)	PUNCT
admet-544	18	33	,	,	PUNCT
admet-544	18	34	myeloma	myeloma	PROPN
admet-544	18	35	(	(	PUNCT
admet-544	18	36	carfilzomib	carfilzomib	PROPN
admet-544	18	37	)	)	PUNCT
admet-544	18	38	and	and	CCONJ
admet-544	18	39	a	a	DET
admet-544	18	40	few	few	ADJ
admet-544	18	41	new	new	ADJ
admet-544	18	42	peptides	peptide	NOUN
admet-544	18	43	in	in	ADP
admet-544	18	44	phase	phase	NOUN
admet-544	18	45	iii	iii	NUM
admet-544	18	46	clinical	clinical	ADJ
admet-544	18	47	trials	trial	NOUN
admet-544	18	48	for	for	ADP
admet-544	18	49	osteoporosis	osteoporosis	NOUN
admet-544	18	50	and	and	CCONJ
admet-544	18	51	type	type	NOUN
admet-544	18	52	ii	ii	NOUN
admet-544	18	53	diabetes	diabetes	NOUN
admet-544	18	54	.	.	PUNCT
admet-544	19	1	it	it	PRON
admet-544	19	2	is	be	AUX
admet-544	19	3	worth	worth	ADJ
admet-544	19	4	mentioning	mention	VERB
admet-544	19	5	that	that	SCONJ
admet-544	19	6	6	6	NUM
admet-544	19	7	peptides	peptide	NOUN
admet-544	19	8	therapeutics	therapeutic	NOUN
admet-544	19	9	out	out	ADP
admet-544	19	10	of	of	ADP
admet-544	19	11	14	14	NUM
admet-544	19	12	which	which	PRON
admet-544	19	13	are	be	AUX
admet-544	19	14	in	in	ADP
admet-544	19	15	phase	phase	NOUN
admet-544	19	16	iii	iii	NUM
admet-544	19	17	clinical	clinical	ADJ
admet-544	19	18	trials	trial	NOUN
admet-544	19	19	[	[	X
admet-544	19	20	1	1	X
admet-544	19	21	]	]	PUNCT
admet-544	19	22	are	be	AUX
admet-544	19	23	targeting	target	VERB
admet-544	19	24	central	central	ADJ
admet-544	19	25	nervous	nervous	ADJ
admet-544	19	26	system	system	NOUN
admet-544	19	27	(	(	PUNCT
admet-544	19	28	cns	cns	NOUN
admet-544	19	29	)	)	PUNCT
admet-544	19	30	.	.	PUNCT
admet-544	20	1	peptide	peptide	NOUN
admet-544	20	2	therapeutics	therapeutic	NOUN
admet-544	20	3	are	be	AUX
admet-544	20	4	able	able	ADJ
admet-544	20	5	to	to	PART
admet-544	20	6	inhibit	inhibit	VERB
admet-544	20	7	protein	protein	NOUN
admet-544	20	8	-	-	PUNCT
admet-544	20	9	protein	protein	NOUN
admet-544	20	10	interactions	interaction	NOUN
admet-544	20	11	(	(	PUNCT
admet-544	20	12	ppi	ppi	NOUN
admet-544	20	13	)	)	PUNCT
admet-544	20	14	and	and	CCONJ
admet-544	20	15	are	be	AUX
admet-544	20	16	opening	open	VERB
admet-544	20	17	up	up	ADP
admet-544	20	18	numerous	numerous	ADJ
admet-544	20	19	ppi	ppi	NOUN
admet-544	20	20	targets	target	NOUN
admet-544	20	21	for	for	ADP
admet-544	20	22	peptides	peptide	NOUN
admet-544	20	23	and	and	CCONJ
admet-544	20	24	macrocyclic	macrocyclic	ADJ
admet-544	20	25	large	large	ADJ
admet-544	20	26	molecules	molecule	NOUN
admet-544	20	27	that	that	PRON
admet-544	20	28	are	be	AUX
admet-544	20	29	outside	outside	ADP
admet-544	20	30	the	the	DET
admet-544	20	31	traditional	traditional	ADJ
admet-544	20	32	drug	drug	NOUN
admet-544	20	33	property	property	NOUN
admet-544	20	34	space	space	NOUN
admet-544	20	35	as	as	SCONJ
admet-544	20	36	defined	define	VERB
admet-544	20	37	by	by	ADP
admet-544	20	38	the	the	DET
admet-544	20	39	lipinski	lipinski	PROPN
admet-544	20	40	rule	rule	NOUN
admet-544	20	41	of	of	ADP
admet-544	20	42	five	five	NUM
admet-544	20	43	[	[	X
admet-544	20	44	3	3	NUM
admet-544	20	45	]	]	PUNCT
admet-544	20	46	.	.	PUNCT
admet-544	21	1	in	in	ADP
admet-544	21	2	general	general	ADJ
admet-544	21	3	,	,	PUNCT
admet-544	21	4	peptides	peptide	NOUN
admet-544	21	5	are	be	AUX
admet-544	21	6	selective	selective	ADJ
admet-544	21	7	and	and	CCONJ
admet-544	21	8	efficacious	efficacious	ADJ
admet-544	21	9	signalling	signal	VERB
admet-544	21	10	molecules	molecule	NOUN
admet-544	21	11	such	such	ADJ
admet-544	21	12	as	as	ADP
admet-544	21	13	hormones	hormone	NOUN
admet-544	21	14	,	,	PUNCT
admet-544	21	15	neurotransmitters	neurotransmitter	NOUN
admet-544	21	16	,	,	PUNCT
admet-544	21	17	growth	growth	NOUN
admet-544	21	18	factors	factor	NOUN
admet-544	21	19	and	and	CCONJ
admet-544	21	20	ion	ion	NOUN
admet-544	21	21	channel	channel	NOUN
admet-544	21	22	ligands	ligand	NOUN
admet-544	21	23	.	.	PUNCT
admet-544	22	1	however	however	ADV
admet-544	22	2	,	,	PUNCT
admet-544	22	3	there	there	PRON
admet-544	22	4	are	be	VERB
admet-544	22	5	several	several	ADJ
admet-544	22	6	issues	issue	NOUN
admet-544	22	7	with	with	ADP
admet-544	22	8	peptide	peptide	ADJ
admet-544	22	9	therapeutics	therapeutic	NOUN
admet-544	22	10	that	that	PRON
admet-544	22	11	have	have	VERB
admet-544	22	12	to	to	PART
admet-544	22	13	be	be	AUX
admet-544	22	14	resolved	resolve	VERB
admet-544	22	15	.	.	PUNCT
admet-544	23	1	in	in	ADP
admet-544	23	2	spite	spite	NOUN
admet-544	23	3	of	of	ADP
admet-544	23	4	usually	usually	ADV
admet-544	23	5	being	be	AUX
admet-544	23	6	water	water	NOUN
admet-544	23	7	soluble	soluble	ADJ
admet-544	23	8	,	,	PUNCT
admet-544	23	9	their	their	PRON
admet-544	23	10	oral	oral	ADJ
admet-544	23	11	absorption	absorption	NOUN
admet-544	23	12	is	be	AUX
admet-544	23	13	compromised	compromise	VERB
admet-544	23	14	because	because	SCONJ
admet-544	23	15	of	of	ADP
admet-544	23	16	peptide	peptide	ADJ
admet-544	23	17	hydrolysis	hydrolysis	NOUN
admet-544	23	18	occurring	occur	VERB
admet-544	23	19	in	in	ADP
admet-544	23	20	the	the	DET
admet-544	23	21	gastrointestinal	gastrointestinal	ADJ
admet-544	23	22	tract	tract	NOUN
admet-544	23	23	.	.	PUNCT
admet-544	24	1	proteolytic	proteolytic	ADJ
admet-544	24	2	enzymes	enzyme	NOUN
admet-544	24	3	can	can	AUX
admet-544	24	4	decompose	decompose	VERB
admet-544	24	5	peptides	peptide	NOUN
admet-544	24	6	quickly	quickly	ADV
admet-544	24	7	resulting	result	VERB
admet-544	24	8	in	in	ADP
admet-544	24	9	short	short	ADJ
admet-544	24	10	plasma	plasma	NOUN
admet-544	24	11	halflife	halflife	NOUN
admet-544	24	12	even	even	ADV
admet-544	24	13	when	when	SCONJ
admet-544	24	14	the	the	DET
admet-544	24	15	peptides	peptide	NOUN
admet-544	24	16	are	be	AUX
admet-544	24	17	administered	administer	VERB
admet-544	24	18	intravenously	intravenously	ADV
admet-544	24	19	[	[	X
admet-544	24	20	4	4	NUM
admet-544	24	21	]	]	PUNCT
admet-544	24	22	.	.	PUNCT
admet-544	25	1	approaches	approach	NOUN
admet-544	25	2	to	to	PART
admet-544	25	3	extend	extend	VERB
admet-544	25	4	the	the	DET
admet-544	25	5	plasma	plasma	NOUN
admet-544	25	6	half	half	ADJ
admet-544	25	7	-	-	PUNCT
admet-544	25	8	life	life	NOUN
admet-544	25	9	include	include	VERB
admet-544	25	10	substitution	substitution	NOUN
admet-544	25	11	of	of	ADP
admet-544	25	12	cleavage	cleavage	NOUN
admet-544	25	13	sites	site	NOUN
admet-544	25	14	by	by	ADP
admet-544	25	15	other	other	ADJ
admet-544	25	16	amino	amino	ADJ
admet-544	25	17	acids	acid	NOUN
admet-544	25	18	,	,	PUNCT
admet-544	25	19	or	or	CCONJ
admet-544	25	20	to	to	PART
admet-544	25	21	change	change	VERB
admet-544	25	22	the	the	DET
admet-544	25	23	folding	folding	NOUN
admet-544	25	24	through	through	ADP
admet-544	25	25	enhancement	enhancement	NOUN
admet-544	25	26	of	of	ADP
admet-544	25	27	the	the	DET
admet-544	25	28	secondary	secondary	ADJ
admet-544	25	29	structure	structure	NOUN
admet-544	25	30	of	of	ADP
admet-544	25	31	the	the	DET
admet-544	25	32	peptide	peptide	NOUN
admet-544	25	33	.	.	PUNCT
admet-544	26	1	it	it	PRON
admet-544	26	2	is	be	AUX
admet-544	26	3	common	common	ADJ
admet-544	26	4	to	to	PART
admet-544	26	5	use	use	VERB
admet-544	26	6	lactam	lactam	NOUN
admet-544	26	7	bridges	bridge	NOUN
admet-544	26	8	,	,	PUNCT
admet-544	26	9	cyclisation	cyclisation	NOUN
admet-544	26	10	and	and	CCONJ
admet-544	26	11	acylation	acylation	NOUN
admet-544	26	12	.	.	PUNCT
admet-544	27	1	another	another	DET
admet-544	27	2	approach	approach	NOUN
admet-544	27	3	is	be	AUX
admet-544	27	4	to	to	PART
admet-544	27	5	increase	increase	VERB
admet-544	27	6	the	the	DET
admet-544	27	7	serum	serum	NOUN
admet-544	27	8	albumin	albumin	NOUN
admet-544	27	9	binding	bind	VERB
admet-544	27	10	of	of	ADP
admet-544	27	11	peptide	peptide	ADJ
admet-544	27	12	therapeutics	therapeutic	NOUN
admet-544	27	13	to	to	PART
admet-544	27	14	potentially	potentially	ADV
admet-544	27	15	increase	increase	VERB
admet-544	27	16	the	the	DET
admet-544	27	17	plasma	plasma	NOUN
admet-544	27	18	half	half	ADJ
admet-544	27	19	-	-	PUNCT
admet-544	27	20	life	life	NOUN
admet-544	27	21	[	[	X
admet-544	27	22	4	4	NUM
admet-544	27	23	]	]	PUNCT
admet-544	27	24	.	.	PUNCT
admet-544	28	1	therefore	therefore	ADV
admet-544	28	2	,	,	PUNCT
admet-544	28	3	measurements	measurement	NOUN
admet-544	28	4	of	of	ADP
admet-544	28	5	albumin	albumin	ADJ
admet-544	28	6	binding	binding	NOUN
admet-544	28	7	of	of	ADP
admet-544	28	8	potential	potential	ADJ
admet-544	28	9	peptide	peptide	NOUN
admet-544	28	10	therapeutics	therapeutic	NOUN
admet-544	28	11	are	be	AUX
admet-544	28	12	very	very	ADV
admet-544	28	13	important	important	ADJ
admet-544	28	14	.	.	PUNCT
admet-544	29	1	it	it	PRON
admet-544	29	2	is	be	AUX
admet-544	29	3	possible	possible	ADJ
admet-544	29	4	that	that	SCONJ
admet-544	29	5	pharmacologically	pharmacologically	ADV
admet-544	29	6	active	active	ADJ
admet-544	29	7	peptide	peptide	NOUN
admet-544	29	8	therapeutics	therapeutic	NOUN
admet-544	29	9	do	do	AUX
admet-544	29	10	not	not	PART
admet-544	29	11	necessarily	necessarily	ADV
admet-544	29	12	possess	possess	VERB
admet-544	29	13	long	long	ADJ
admet-544	29	14	plasma	plasma	NOUN
admet-544	29	15	half	half	NOUN
admet-544	29	16	-	-	PUNCT
admet-544	29	17	lives	life	NOUN
admet-544	29	18	.	.	PUNCT
admet-544	30	1	for	for	ADP
admet-544	30	2	example	example	NOUN
admet-544	30	3	,	,	PUNCT
admet-544	30	4	studies	study	NOUN
admet-544	30	5	on	on	ADP
admet-544	30	6	sgx93	sgx93	PROPN
admet-544	30	7	(	(	PUNCT
admet-544	30	8	soligenix	soligenix	PROPN
admet-544	30	9	inc	inc	PROPN
admet-544	30	10	)	)	PUNCT
admet-544	31	1	[	[	X
admet-544	31	2	5	5	NUM
admet-544	31	3	]	]	PUNCT
admet-544	31	4	,	,	PUNCT
admet-544	31	5	a	a	DET
admet-544	31	6	short	short	ADJ
admet-544	31	7	peptide	peptide	NOUN
admet-544	31	8	drug	drug	NOUN
admet-544	31	9	candidate	candidate	NOUN
admet-544	31	10	that	that	PRON
admet-544	31	11	exhibited	exhibit	VERB
admet-544	31	12	potential	potential	NOUN
admet-544	31	13	in	in	ADP
admet-544	31	14	oral	oral	ADJ
admet-544	31	15	mucositis	mucositis	NOUN
admet-544	31	16	in	in	ADP
admet-544	31	17	clinical	clinical	ADJ
admet-544	31	18	trials	trial	NOUN
admet-544	31	19	showed	show	VERB
admet-544	31	20	a	a	DET
admet-544	31	21	rapid	rapid	ADJ
admet-544	31	22	degradation	degradation	NOUN
admet-544	31	23	in	in	ADP
admet-544	31	24	plasma	plasma	NOUN
admet-544	31	25	.	.	PUNCT
admet-544	32	1	due	due	ADP
admet-544	32	2	to	to	ADP
admet-544	32	3	their	their	PRON
admet-544	32	4	polar	polar	ADJ
admet-544	32	5	nature	nature	NOUN
admet-544	32	6	,	,	PUNCT
admet-544	32	7	peptides	peptide	NOUN
admet-544	32	8	often	often	ADV
admet-544	32	9	have	have	VERB
admet-544	32	10	limited	limit	VERB
admet-544	32	11	cell	cell	NOUN
admet-544	32	12	permeability	permeability	NOUN
admet-544	32	13	.	.	PUNCT
admet-544	33	1	cyclisation	cyclisation	NOUN
admet-544	33	2	,	,	PUNCT
admet-544	33	3	reduction	reduction	NOUN
admet-544	33	4	of	of	ADP
admet-544	33	5	the	the	DET
admet-544	33	6	hbond	hbond	ADJ
admet-544	33	7	donor	donor	NOUN
admet-544	33	8	groups	group	NOUN
admet-544	33	9	and	and	CCONJ
admet-544	33	10	other	other	ADJ
admet-544	33	11	methods	method	NOUN
admet-544	33	12	have	have	AUX
admet-544	33	13	been	be	AUX
admet-544	33	14	tried	try	VERB
admet-544	33	15	to	to	PART
admet-544	33	16	identify	identify	VERB
admet-544	33	17	cell	cell	NOUN
admet-544	33	18	-	-	PUNCT
admet-544	33	19	permeable	permeable	ADJ
admet-544	33	20	peptides	peptide	NOUN
admet-544	33	21	(	(	PUNCT
admet-544	33	22	cpp	cpp	NOUN
admet-544	33	23	)	)	PUNCT
admet-544	34	1	[	[	X
admet-544	34	2	6	6	NUM
admet-544	34	3	-	-	SYM
admet-544	34	4	7	7	NUM
admet-544	34	5	]	]	PUNCT
admet-544	34	6	.	.	PUNCT
admet-544	35	1	there	there	PRON
admet-544	35	2	are	be	VERB
admet-544	35	3	three	three	NUM
admet-544	35	4	possible	possible	ADJ
admet-544	35	5	mechanisms	mechanism	NOUN
admet-544	35	6	by	by	ADP
admet-544	35	7	which	which	PRON
admet-544	35	8	peptides	peptide	NOUN
admet-544	35	9	can	can	AUX
admet-544	35	10	enter	enter	VERB
admet-544	35	11	into	into	ADP
admet-544	35	12	the	the	DET
admet-544	35	13	cell	cell	NOUN
admet-544	35	14	:	:	PUNCT
admet-544	36	1	1	1	X
admet-544	36	2	.	.	X
admet-544	36	3	the	the	DET
admet-544	36	4	inverted	inverted	ADJ
admet-544	36	5	micelle	micelle	NOUN
admet-544	36	6	model	model	NOUN
admet-544	36	7	;	;	PUNCT
admet-544	36	8	2	2	X
admet-544	36	9	.	.	X
admet-544	36	10	direct	direct	ADJ
admet-544	36	11	penetration	penetration	NOUN
admet-544	36	12	and	and	CCONJ
admet-544	36	13	3	3	NUM
admet-544	36	14	.	.	NOUN
admet-544	36	15	endocytic	endocytic	ADJ
admet-544	36	16	uptake	uptake	NOUN
admet-544	36	17	[	[	X
admet-544	36	18	8	8	NUM
admet-544	36	19	]	]	PUNCT
admet-544	36	20	.	.	PUNCT
admet-544	37	1	when	when	SCONJ
admet-544	37	2	the	the	DET
admet-544	37	3	target	target	NOUN
admet-544	37	4	is	be	AUX
admet-544	37	5	intracellular	intracellular	ADJ
admet-544	37	6	it	it	PRON
admet-544	37	7	is	be	AUX
admet-544	37	8	important	important	ADJ
admet-544	37	9	to	to	PART
admet-544	37	10	design	design	VERB
admet-544	37	11	cell	cell	NOUN
admet-544	37	12	penetrating	penetrate	VERB
admet-544	37	13	peptide	peptide	NOUN
admet-544	37	14	therapeutics	therapeutic	NOUN
admet-544	37	15	[	[	X
admet-544	37	16	9	9	NUM
admet-544	37	17	-	-	SYM
admet-544	37	18	10	10	NUM
admet-544	37	19	]	]	PUNCT
admet-544	37	20	.	.	PUNCT
admet-544	38	1	various	various	ADJ
admet-544	38	2	mechanisms	mechanism	NOUN
admet-544	38	3	on	on	ADP
admet-544	38	4	how	how	SCONJ
admet-544	38	5	peptides	peptide	NOUN
admet-544	38	6	can	can	AUX
admet-544	38	7	enter	enter	VERB
admet-544	38	8	into	into	ADP
admet-544	38	9	the	the	DET
admet-544	38	10	cells	cell	NOUN
admet-544	38	11	have	have	AUX
admet-544	38	12	been	be	AUX
admet-544	38	13	reviewed	review	VERB
admet-544	38	14	by	by	ADP
admet-544	38	15	madani	madani	PROPN
admet-544	38	16	et	et	PROPN
admet-544	38	17	al	al	PROPN
admet-544	38	18	.	.	PUNCT
admet-544	39	1	[	[	X
admet-544	39	2	11	11	NUM
admet-544	39	3	]	]	PUNCT
admet-544	39	4	.	.	PUNCT
admet-544	40	1	all	all	PRON
admet-544	40	2	of	of	ADP
admet-544	40	3	the	the	DET
admet-544	40	4	aforementioned	aforementione	VERB
admet-544	40	5	mechanisms	mechanism	NOUN
admet-544	40	6	require	require	VERB
admet-544	40	7	the	the	DET
admet-544	40	8	peptide	peptide	NOUN
admet-544	40	9	to	to	PART
admet-544	40	10	have	have	VERB
admet-544	40	11	good	good	ADJ
admet-544	40	12	affinity	affinity	NOUN
admet-544	40	13	to	to	ADP
admet-544	40	14	the	the	DET
admet-544	40	15	negatively	negatively	ADV
admet-544	40	16	charged	charge	VERB
admet-544	40	17	membrane	membrane	NOUN
admet-544	40	18	surface	surface	NOUN
admet-544	40	19	.	.	PUNCT
admet-544	41	1	thus	thus	ADV
admet-544	41	2	including	include	VERB
admet-544	41	3	arginine	arginine	NOUN
admet-544	41	4	in	in	ADP
admet-544	41	5	the	the	DET
admet-544	41	6	sequence	sequence	NOUN
admet-544	41	7	could	could	AUX
admet-544	41	8	offer	offer	VERB
admet-544	41	9	the	the	DET
admet-544	41	10	potential	potential	NOUN
admet-544	41	11	to	to	PART
admet-544	41	12	increases	increase	VERB
admet-544	41	13	the	the	DET
admet-544	41	14	cell	cell	NOUN
admet-544	41	15	permeability	permeability	NOUN
admet-544	41	16	of	of	ADP
admet-544	41	17	the	the	DET
admet-544	41	18	peptides	peptide	NOUN
admet-544	41	19	[	[	X
admet-544	41	20	12	12	NUM
admet-544	41	21	]	]	PUNCT
admet-544	41	22	.	.	PUNCT
admet-544	42	1	chromatography	chromatography	NOUN
admet-544	42	2	using	use	VERB
admet-544	42	3	immobilized	immobilized	ADJ
admet-544	42	4	artificial	artificial	ADJ
admet-544	42	5	membrane	membrane	NOUN
admet-544	42	6	(	(	PUNCT
admet-544	42	7	iam	iam	PROPN
admet-544	42	8	)	)	PUNCT
admet-544	42	9	as	as	ADP
admet-544	42	10	a	a	DET
admet-544	42	11	stationary	stationary	ADJ
admet-544	42	12	phase	phase	NOUN
admet-544	42	13	[	[	X
admet-544	42	14	13	13	NUM
admet-544	42	15	-	-	SYM
admet-544	42	16	14	14	NUM
admet-544	42	17	]	]	PUNCT
admet-544	42	18	is	be	AUX
admet-544	42	19	a	a	DET
admet-544	42	20	promising	promising	ADJ
admet-544	42	21	tool	tool	NOUN
admet-544	42	22	to	to	PART
admet-544	42	23	measure	measure	VERB
admet-544	42	24	the	the	DET
admet-544	42	25	affinity	affinity	NOUN
admet-544	42	26	of	of	ADP
admet-544	42	27	the	the	DET
admet-544	42	28	peptide	peptide	NOUN
admet-544	42	29	to	to	ADP
admet-544	42	30	the	the	DET
admet-544	42	31	phospholipid	phospholipid	NOUN
admet-544	42	32	membrane	membrane	NOUN
admet-544	42	33	and	and	CCONJ
admet-544	42	34	relate	relate	VERB
admet-544	42	35	it	it	PRON
admet-544	42	36	to	to	ADP
admet-544	42	37	cell	cell	NOUN
admet-544	42	38	permeability	permeability	NOUN
admet-544	42	39	.	.	PUNCT
admet-544	43	1	another	another	DET
admet-544	43	2	aspect	aspect	NOUN
admet-544	43	3	of	of	ADP
admet-544	43	4	the	the	DET
admet-544	43	5	rational	rational	ADJ
admet-544	43	6	design	design	NOUN
admet-544	43	7	of	of	ADP
admet-544	43	8	peptide	peptide	ADJ
admet-544	43	9	therapeutics	therapeutic	NOUN
admet-544	43	10	is	be	AUX
admet-544	43	11	to	to	PART
admet-544	43	12	improve	improve	VERB
admet-544	43	13	their	their	PRON
admet-544	43	14	physicochemical	physicochemical	ADJ
admet-544	43	15	properties	property	NOUN
admet-544	43	16	,	,	PUNCT
admet-544	43	17	such	such	ADJ
admet-544	43	18	as	as	ADP
admet-544	43	19	solubility	solubility	NOUN
admet-544	43	20	and	and	CCONJ
admet-544	43	21	stability	stability	NOUN
admet-544	43	22	and	and	CCONJ
admet-544	43	23	to	to	PART
admet-544	43	24	avoid	avoid	VERB
admet-544	43	25	aggregation	aggregation	NOUN
admet-544	43	26	.	.	PUNCT
admet-544	44	1	the	the	DET
admet-544	44	2	stability	stability	NOUN
admet-544	44	3	of	of	ADP
admet-544	44	4	peptides	peptide	NOUN
admet-544	44	5	can	can	AUX
admet-544	44	6	be	be	AUX
admet-544	44	7	improved	improve	VERB
admet-544	44	8	by	by	ADP
admet-544	44	9	stabilizing	stabilize	VERB
admet-544	44	10	α	α	NOUN
admet-544	44	11	-	-	PUNCT
admet-544	44	12	helixes	helix	NOUN
admet-544	44	13	,	,	PUNCT
admet-544	44	14	salt	salt	NOUN
admet-544	44	15	bridges	bridge	NOUN
admet-544	44	16	or	or	CCONJ
admet-544	44	17	lactam	lactam	NOUN
admet-544	44	18	bridges	bridge	NOUN
admet-544	44	19	.	.	PUNCT
admet-544	45	1	therefore	therefore	ADV
admet-544	45	2	,	,	PUNCT
admet-544	45	3	several	several	ADJ
admet-544	45	4	efforts	effort	NOUN
admet-544	45	5	have	have	AUX
admet-544	45	6	been	be	AUX
admet-544	45	7	published	publish	VERB
admet-544	45	8	[	[	X
admet-544	45	9	6,15–19	6,15–19	NUM
admet-544	45	10	]	]	PUNCT
admet-544	45	11	,	,	PUNCT
admet-544	45	12	for	for	ADP
admet-544	45	13	the	the	DET
admet-544	45	14	synthesis	synthesis	NOUN
admet-544	45	15	of	of	ADP
admet-544	45	16	rigid	rigid	ADJ
admet-544	45	17	or	or	CCONJ
admet-544	45	18	flexible	flexible	ADJ
admet-544	45	19	cyclic	cyclic	ADJ
admet-544	45	20	peptides	peptide	NOUN
admet-544	45	21	in	in	ADP
admet-544	45	22	relation	relation	NOUN
admet-544	45	23	to	to	ADP
admet-544	45	24	their	their	PRON
admet-544	45	25	cell	cell	NOUN
admet-544	45	26	permeability	permeability	NOUN
admet-544	45	27	.	.	PUNCT
admet-544	46	1	due	due	ADP
admet-544	46	2	to	to	ADP
admet-544	46	3	the	the	DET
admet-544	46	4	low	low	ADJ
admet-544	46	5	oral	oral	ADJ
admet-544	46	6	bioavailability	bioavailability	NOUN
admet-544	46	7	of	of	ADP
admet-544	46	8	peptides	peptide	NOUN
admet-544	46	9	,	,	PUNCT
admet-544	46	10	various	various	ADJ
admet-544	46	11	formulation	formulation	NOUN
admet-544	46	12	strategies	strategy	NOUN
admet-544	46	13	have	have	AUX
admet-544	46	14	been	be	AUX
admet-544	46	15	developed	develop	VERB
admet-544	46	16	such	such	ADJ
admet-544	46	17	as	as	ADP
admet-544	46	18	liquid	liquid	ADJ
admet-544	46	19	formulations	formulation	NOUN
admet-544	46	20	.	.	PUNCT
admet-544	47	1	the	the	DET
admet-544	47	2	search	search	NOUN
admet-544	47	3	for	for	ADP
admet-544	47	4	a	a	DET
admet-544	47	5	non	non	ADJ
admet-544	47	6	-	-	ADJ
admet-544	47	7	conventional	conventional	ADJ
admet-544	47	8	administration	administration	NOUN
admet-544	47	9	route	route	NOUN
admet-544	47	10	such	such	ADJ
admet-544	47	11	as	as	ADP
admet-544	47	12	inhaled	inhaled	ADJ
admet-544	47	13	,	,	PUNCT
admet-544	47	14	topical	topical	ADJ
admet-544	47	15	or	or	CCONJ
admet-544	47	16	intravenous	intravenous	ADJ
admet-544	47	17	is	be	AUX
admet-544	47	18	a	a	DET
admet-544	47	19	potential	potential	ADJ
admet-544	47	20	option	option	NOUN
admet-544	47	21	to	to	PART
admet-544	47	22	improve	improve	VERB
admet-544	47	23	bioavailability	bioavailability	NOUN
admet-544	47	24	.	.	PUNCT
admet-544	48	1	klara	klara	PROPN
admet-544	48	2	valko	valko	PROPN
admet-544	48	3	et	et	PROPN
admet-544	48	4	al	al	PROPN
admet-544	48	5	.	.	PROPN
admet-544	48	6	admet	admet	PROPN
admet-544	48	7	&	&	CCONJ
admet-544	48	8	dmpk	dmpk	PROPN
admet-544	48	9	6(2	6(2	NUM
admet-544	48	10	)	)	PUNCT
admet-544	48	11	(	(	PUNCT
admet-544	48	12	2018	2018	NUM
admet-544	48	13	)	)	PUNCT
admet-544	48	14	162	162	NUM
admet-544	48	15	-	-	SYM
admet-544	48	16	175	175	NUM
admet-544	48	17	164	164	NUM
admet-544	48	18	therefore	therefore	ADV
admet-544	48	19	,	,	PUNCT
admet-544	48	20	any	any	DET
admet-544	48	21	predictive	predictive	ADJ
admet-544	48	22	tool	tool	NOUN
admet-544	48	23	that	that	PRON
admet-544	48	24	can	can	AUX
admet-544	48	25	be	be	AUX
admet-544	48	26	used	use	VERB
admet-544	48	27	to	to	PART
admet-544	48	28	estimate	estimate	VERB
admet-544	48	29	the	the	DET
admet-544	48	30	in	in	ADP
admet-544	48	31	vivo	vivo	ADJ
admet-544	48	32	distribution	distribution	NOUN
admet-544	48	33	of	of	ADP
admet-544	48	34	potential	potential	ADJ
admet-544	48	35	peptide	peptide	NOUN
admet-544	48	36	therapeutics	therapeutic	NOUN
admet-544	48	37	would	would	AUX
admet-544	48	38	be	be	AUX
admet-544	48	39	very	very	ADV
admet-544	48	40	valuable	valuable	ADJ
admet-544	48	41	.	.	PUNCT
admet-544	49	1	lipophilicity	lipophilicity	NOUN
admet-544	49	2	of	of	ADP
admet-544	49	3	molecules	molecule	NOUN
admet-544	49	4	,	,	PUNCT
admet-544	49	5	expressed	express	VERB
admet-544	49	6	as	as	ADP
admet-544	49	7	an	an	DET
admet-544	49	8	octanol	octanol	NOUN
admet-544	49	9	/	/	SYM
admet-544	49	10	water	water	NOUN
admet-544	49	11	partition	partition	NOUN
admet-544	49	12	coefficient	coefficient	NOUN
admet-544	49	13	(	(	PUNCT
admet-544	49	14	log	log	NOUN
admet-544	49	15	d	d	NOUN
admet-544	49	16	)	)	PUNCT
admet-544	49	17	,	,	PUNCT
admet-544	49	18	has	have	AUX
admet-544	49	19	been	be	AUX
admet-544	49	20	used	use	VERB
admet-544	49	21	traditionally	traditionally	ADV
admet-544	49	22	to	to	PART
admet-544	49	23	model	model	VERB
admet-544	49	24	biological	biological	ADJ
admet-544	49	25	distribution	distribution	NOUN
admet-544	49	26	processes	process	NOUN
admet-544	49	27	[	[	X
admet-544	49	28	20	20	NUM
admet-544	49	29	]	]	PUNCT
admet-544	49	30	.	.	PUNCT
admet-544	50	1	it	it	PRON
admet-544	50	2	was	be	AUX
admet-544	50	3	found	find	VERB
admet-544	50	4	that	that	SCONJ
admet-544	50	5	the	the	DET
admet-544	50	6	traditional	traditional	ADJ
admet-544	50	7	octanol	octanol	NOUN
admet-544	50	8	/	/	SYM
admet-544	50	9	water	water	NOUN
admet-544	50	10	partition	partition	NOUN
admet-544	50	11	coefficient	coefficient	NOUN
admet-544	50	12	measurements	measurement	NOUN
admet-544	50	13	were	be	AUX
admet-544	50	14	not	not	PART
admet-544	50	15	suitable	suitable	ADJ
admet-544	50	16	for	for	ADP
admet-544	50	17	the	the	DET
admet-544	50	18	lipophilicity	lipophilicity	NOUN
admet-544	50	19	determination	determination	NOUN
admet-544	50	20	of	of	ADP
admet-544	50	21	peptides	peptide	NOUN
admet-544	50	22	as	as	SCONJ
admet-544	50	23	peptides	peptide	NOUN
admet-544	50	24	are	be	AUX
admet-544	50	25	charged	charge	VERB
admet-544	50	26	and	and	CCONJ
admet-544	50	27	very	very	ADV
admet-544	50	28	polar	polar	ADJ
admet-544	50	29	and	and	CCONJ
admet-544	50	30	do	do	AUX
admet-544	50	31	not	not	PART
admet-544	50	32	partition	partition	VERB
admet-544	50	33	into	into	ADP
admet-544	50	34	octanol	octanol	NOUN
admet-544	50	35	at	at	ADV
admet-544	50	36	all	all	ADV
admet-544	50	37	[	[	X
admet-544	50	38	21	21	NUM
admet-544	50	39	]	]	PUNCT
admet-544	50	40	.	.	PUNCT
admet-544	51	1	moreover	moreover	ADV
admet-544	51	2	it	it	PRON
admet-544	51	3	is	be	AUX
admet-544	51	4	likely	likely	ADJ
admet-544	51	5	peptides	peptide	NOUN
admet-544	51	6	could	could	AUX
admet-544	51	7	be	be	AUX
admet-544	51	8	concentrated	concentrate	VERB
admet-544	51	9	on	on	ADP
admet-544	51	10	the	the	DET
admet-544	51	11	interface	interface	NOUN
admet-544	51	12	between	between	ADP
admet-544	51	13	the	the	DET
admet-544	51	14	octanol	octanol	NOUN
admet-544	51	15	and	and	CCONJ
admet-544	51	16	the	the	DET
admet-544	51	17	water	water	NOUN
admet-544	51	18	.	.	PUNCT
admet-544	52	1	for	for	ADP
admet-544	52	2	instance	instance	NOUN
admet-544	52	3	,	,	PUNCT
admet-544	52	4	surface	surface	VERB
admet-544	52	5	active	active	ADJ
admet-544	52	6	peptides	peptide	NOUN
admet-544	52	7	may	may	AUX
admet-544	52	8	help	help	VERB
admet-544	52	9	to	to	PART
admet-544	52	10	form	form	VERB
admet-544	52	11	foams	foam	NOUN
admet-544	52	12	and	and	CCONJ
admet-544	52	13	emulsions	emulsion	NOUN
admet-544	52	14	that	that	PRON
admet-544	52	15	make	make	VERB
admet-544	52	16	the	the	DET
admet-544	52	17	log	log	NOUN
admet-544	52	18	d	d	NOUN
admet-544	52	19	determination	determination	NOUN
admet-544	52	20	very	very	ADV
admet-544	52	21	difficult	difficult	ADJ
admet-544	52	22	.	.	PUNCT
admet-544	53	1	there	there	PRON
admet-544	53	2	is	be	VERB
admet-544	53	3	a	a	DET
admet-544	53	4	study	study	NOUN
admet-544	53	5	that	that	PRON
admet-544	53	6	describes	describe	VERB
admet-544	53	7	a	a	DET
admet-544	53	8	possible	possible	ADJ
admet-544	53	9	calculation	calculation	NOUN
admet-544	53	10	method	method	NOUN
admet-544	53	11	using	use	VERB
admet-544	53	12	3d	3d	NUM
admet-544	53	13	descriptors	descriptor	NOUN
admet-544	53	14	for	for	ADP
admet-544	53	15	the	the	DET
admet-544	53	16	lipophilicity	lipophilicity	NOUN
admet-544	53	17	of	of	ADP
admet-544	53	18	the	the	DET
admet-544	53	19	peptides	peptide	NOUN
admet-544	53	20	in	in	ADP
admet-544	53	21	the	the	DET
admet-544	53	22	octanol	octanol	NOUN
admet-544	53	23	/	/	SYM
admet-544	53	24	water	water	NOUN
admet-544	53	25	system	system	NOUN
admet-544	53	26	[	[	X
admet-544	53	27	22	22	NUM
admet-544	53	28	]	]	PUNCT
admet-544	53	29	.	.	PUNCT
admet-544	54	1	in	in	ADP
admet-544	54	2	silico	silico	NOUN
admet-544	54	3	calculation	calculation	NOUN
admet-544	54	4	software	software	NOUN
admet-544	54	5	for	for	ADP
admet-544	54	6	log	log	NOUN
admet-544	54	7	d	d	PROPN
admet-544	54	8	provides	provide	VERB
admet-544	54	9	very	very	ADV
admet-544	54	10	low	low	ADJ
admet-544	54	11	calculated	calculate	VERB
admet-544	54	12	lipophilicities	lipophilicitie	NOUN
admet-544	54	13	(	(	PUNCT
admet-544	54	14	below	below	ADP
admet-544	54	15	-5	-5	PUNCT
admet-544	54	16	and	and	CCONJ
admet-544	54	17	-10	-10	NUM
admet-544	54	18	)	)	PUNCT
admet-544	54	19	in	in	ADP
admet-544	54	20	most	most	ADJ
admet-544	54	21	cases	case	NOUN
admet-544	54	22	.	.	PUNCT
admet-544	55	1	for	for	ADP
admet-544	55	2	example	example	NOUN
admet-544	55	3	,	,	PUNCT
admet-544	55	4	in	in	ADP
admet-544	55	5	this	this	DET
admet-544	55	6	study	study	NOUN
admet-544	55	7	the	the	DET
admet-544	55	8	calculated	calculated	ADJ
admet-544	55	9	log	log	NOUN
admet-544	55	10	d	d	NOUN
admet-544	55	11	values	value	NOUN
admet-544	55	12	using	use	VERB
admet-544	55	13	acdlabs	acdlab	NOUN
admet-544	55	14	(	(	PUNCT
admet-544	55	15	advanced	advanced	ADJ
admet-544	55	16	chemical	chemical	PROPN
admet-544	55	17	development	development	PROPN
admet-544	55	18	inc	inc	PROPN
admet-544	55	19	.	.	PROPN
admet-544	55	20	toronto	toronto	PROPN
admet-544	55	21	,	,	PUNCT
admet-544	55	22	canada	canada	PROPN
admet-544	55	23	)	)	PUNCT
admet-544	55	24	software	software	NOUN
admet-544	55	25	for	for	ADP
admet-544	55	26	lp5	lp5	NOUN
admet-544	55	27	was	be	AUX
admet-544	55	28	-9.27	-9.27	ADJ
admet-544	55	29	and	and	CCONJ
admet-544	55	30	for	for	ADP
admet-544	55	31	lp7	lp7	PROPN
admet-544	55	32	it	it	PRON
admet-544	55	33	was	be	AUX
admet-544	55	34	-9.84	-9.84	PRON
admet-544	55	35	.	.	PUNCT
admet-544	56	1	on	on	ADP
admet-544	56	2	the	the	DET
admet-544	56	3	other	other	ADJ
admet-544	56	4	hand	hand	NOUN
admet-544	56	5	,	,	PUNCT
admet-544	56	6	these	these	DET
admet-544	56	7	two	two	NUM
admet-544	56	8	compounds	compound	NOUN
admet-544	56	9	showed	show	VERB
admet-544	56	10	interactions	interaction	NOUN
admet-544	56	11	with	with	ADP
admet-544	56	12	the	the	DET
admet-544	56	13	iam	iam	PROPN
admet-544	56	14	stationary	stationary	ADJ
admet-544	56	15	phase	phase	NOUN
admet-544	56	16	and	and	CCONJ
admet-544	56	17	also	also	ADV
admet-544	56	18	had	have	VERB
admet-544	56	19	retention	retention	NOUN
admet-544	56	20	on	on	ADP
admet-544	56	21	the	the	DET
admet-544	56	22	c-18	c-18	PROPN
admet-544	56	23	stationary	stationary	ADJ
admet-544	56	24	phase	phase	NOUN
admet-544	56	25	.	.	PUNCT
admet-544	57	1	ermondi	ermondi	PROPN
admet-544	57	2	et	et	PROPN
admet-544	57	3	al	al	PROPN
admet-544	57	4	.	.	PUNCT
admet-544	58	1	[	[	X
admet-544	58	2	23	23	NUM
admet-544	58	3	]	]	PUNCT
admet-544	58	4	demonstrated	demonstrate	VERB
admet-544	58	5	that	that	SCONJ
admet-544	58	6	reversed	reverse	VERB
admet-544	58	7	phase	phase	NOUN
admet-544	58	8	chromatography	chromatography	NOUN
admet-544	58	9	could	could	AUX
admet-544	58	10	be	be	AUX
admet-544	58	11	used	use	VERB
admet-544	58	12	to	to	PART
admet-544	58	13	assess	assess	VERB
admet-544	58	14	and	and	CCONJ
admet-544	58	15	compare	compare	VERB
admet-544	58	16	the	the	DET
admet-544	58	17	lipophilicity	lipophilicity	NOUN
admet-544	58	18	of	of	ADP
admet-544	58	19	peptides	peptide	NOUN
admet-544	58	20	.	.	PUNCT
admet-544	59	1	others	other	NOUN
admet-544	59	2	have	have	AUX
admet-544	59	3	also	also	ADV
admet-544	59	4	reported	report	VERB
admet-544	59	5	[	[	PUNCT
admet-544	59	6	24	24	NUM
admet-544	59	7	-	-	SYM
admet-544	59	8	25	25	NUM
admet-544	59	9	]	]	PUNCT
admet-544	59	10	that	that	SCONJ
admet-544	59	11	the	the	DET
admet-544	59	12	lipophilicity	lipophilicity	NOUN
admet-544	59	13	of	of	ADP
admet-544	59	14	peptides	peptide	NOUN
admet-544	59	15	is	be	AUX
admet-544	59	16	an	an	DET
admet-544	59	17	important	important	ADJ
admet-544	59	18	physicochemical	physicochemical	ADJ
admet-544	59	19	property	property	NOUN
admet-544	59	20	and	and	CCONJ
admet-544	59	21	that	that	PRON
admet-544	59	22	reversed	reverse	VERB
admet-544	59	23	phase	phase	NOUN
admet-544	59	24	chromatography	chromatography	NOUN
admet-544	59	25	can	can	AUX
admet-544	59	26	provide	provide	VERB
admet-544	59	27	a	a	DET
admet-544	59	28	tool	tool	NOUN
admet-544	59	29	to	to	PART
admet-544	59	30	assess	assess	VERB
admet-544	59	31	lipophilicity	lipophilicity	NOUN
admet-544	59	32	via	via	ADP
admet-544	59	33	retention	retention	NOUN
admet-544	59	34	time	time	NOUN
admet-544	59	35	measurements	measurement	NOUN
admet-544	59	36	.	.	PUNCT
admet-544	60	1	biswas	biswas	PROPN
admet-544	60	2	et	et	PROPN
admet-544	60	3	al	al	PROPN
admet-544	60	4	.	.	PUNCT
admet-544	61	1	[	[	X
admet-544	61	2	25	25	NUM
admet-544	61	3	]	]	PUNCT
admet-544	61	4	applied	apply	VERB
admet-544	61	5	reversed	reverse	VERB
admet-544	61	6	-	-	PUNCT
admet-544	61	7	phase	phase	NOUN
admet-544	61	8	chromatography	chromatography	NOUN
admet-544	61	9	for	for	ADP
admet-544	61	10	lipophilicity	lipophilicity	NOUN
admet-544	61	11	assessment	assessment	NOUN
admet-544	61	12	of	of	ADP
admet-544	61	13	amino	amino	ADJ
admet-544	61	14	acids	acid	NOUN
admet-544	61	15	and	and	CCONJ
admet-544	61	16	established	establish	VERB
admet-544	61	17	an	an	DET
admet-544	61	18	additivity	additivity	NOUN
admet-544	61	19	rule	rule	NOUN
admet-544	61	20	of	of	ADP
admet-544	61	21	lipophilicity	lipophilicity	NOUN
admet-544	61	22	of	of	ADP
admet-544	61	23	peptides	peptide	NOUN
admet-544	61	24	up	up	ADP
admet-544	61	25	to	to	PART
admet-544	61	26	15	15	NUM
admet-544	61	27	amino	amino	NOUN
admet-544	61	28	acids	acid	NOUN
admet-544	61	29	.	.	PUNCT
admet-544	62	1	however	however	ADV
admet-544	62	2	,	,	PUNCT
admet-544	62	3	the	the	DET
admet-544	62	4	additivity	additivity	NOUN
admet-544	62	5	rule	rule	NOUN
admet-544	62	6	appeared	appear	VERB
admet-544	62	7	to	to	PART
admet-544	62	8	break	break	VERB
admet-544	62	9	down	down	ADP
admet-544	62	10	in	in	ADP
admet-544	62	11	larger	large	ADJ
admet-544	62	12	peptides	peptide	NOUN
admet-544	62	13	due	due	ADP
admet-544	62	14	to	to	ADP
admet-544	62	15	the	the	DET
admet-544	62	16	secondary	secondary	ADJ
admet-544	62	17	structure	structure	NOUN
admet-544	62	18	formation	formation	NOUN
admet-544	62	19	.	.	PUNCT
admet-544	63	1	in	in	ADP
admet-544	63	2	silico	silico	NOUN
admet-544	63	3	predictions	prediction	NOUN
admet-544	63	4	of	of	ADP
admet-544	63	5	reversed	reverse	VERB
admet-544	63	6	phase	phase	NOUN
admet-544	63	7	retention	retention	NOUN
admet-544	63	8	may	may	AUX
admet-544	63	9	provide	provide	VERB
admet-544	63	10	the	the	DET
admet-544	63	11	possibility	possibility	NOUN
admet-544	63	12	to	to	PART
admet-544	63	13	assess	assess	VERB
admet-544	63	14	the	the	DET
admet-544	63	15	lipophilicity	lipophilicity	NOUN
admet-544	63	16	of	of	ADP
admet-544	63	17	peptides	peptide	NOUN
admet-544	63	18	based	base	VERB
admet-544	63	19	on	on	ADP
admet-544	63	20	the	the	DET
admet-544	63	21	retention	retention	NOUN
admet-544	63	22	coefficients	coefficient	NOUN
admet-544	63	23	for	for	ADP
admet-544	63	24	amino	amino	ADJ
admet-544	63	25	acids	acid	NOUN
admet-544	63	26	[	[	X
admet-544	63	27	26	26	NUM
admet-544	63	28	-	-	SYM
admet-544	63	29	28	28	NUM
admet-544	63	30	]	]	PUNCT
admet-544	63	31	.	.	PUNCT
admet-544	64	1	gussakovsky	gussakovsky	NOUN
admet-544	64	2	et	et	PROPN
admet-544	64	3	al	al	PROPN
admet-544	64	4	.	.	PUNCT
admet-544	65	1	[	[	X
admet-544	65	2	29	29	NUM
admet-544	65	3	]	]	PUNCT
admet-544	65	4	analysed	analyse	VERB
admet-544	65	5	over	over	ADP
admet-544	65	6	29	29	NUM
admet-544	65	7	thousand	thousand	NUM
admet-544	65	8	tryptic	tryptic	ADJ
admet-544	65	9	peptides	peptide	NOUN
admet-544	65	10	on	on	ADP
admet-544	65	11	the	the	DET
admet-544	65	12	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	65	13	stationary	stationary	ADJ
admet-544	65	14	phase	phase	NOUN
admet-544	65	15	and	and	CCONJ
admet-544	65	16	compared	compare	VERB
admet-544	65	17	the	the	DET
admet-544	65	18	retention	retention	NOUN
admet-544	65	19	contribution	contribution	NOUN
admet-544	65	20	of	of	ADP
admet-544	65	21	the	the	DET
admet-544	65	22	amino	amino	NOUN
admet-544	65	23	acids	acid	NOUN
admet-544	65	24	with	with	ADP
admet-544	65	25	those	those	PRON
admet-544	65	26	from	from	ADP
admet-544	65	27	the	the	DET
admet-544	65	28	c-18	c-18	PROPN
admet-544	65	29	columns	column	NOUN
admet-544	65	30	.	.	PUNCT
admet-544	66	1	they	they	PRON
admet-544	66	2	found	find	VERB
admet-544	66	3	that	that	SCONJ
admet-544	66	4	amino	amino	NOUN
admet-544	66	5	acids	acid	NOUN
admet-544	66	6	containing	contain	VERB
admet-544	66	7	positive	positive	ADJ
admet-544	66	8	charges	charge	NOUN
admet-544	66	9	such	such	ADJ
admet-544	66	10	as	as	ADP
admet-544	66	11	arginine	arginine	NOUN
admet-544	66	12	and	and	CCONJ
admet-544	66	13	lysine	lysine	NOUN
admet-544	66	14	retain	retain	VERB
admet-544	66	15	stronger	strong	ADJ
admet-544	66	16	on	on	ADP
admet-544	66	17	the	the	DET
admet-544	66	18	iam	iam	PROPN
admet-544	66	19	phase	phase	NOUN
admet-544	66	20	than	than	ADP
admet-544	66	21	on	on	ADP
admet-544	66	22	the	the	DET
admet-544	66	23	c18	c18	NOUN
admet-544	66	24	phase	phase	NOUN
admet-544	66	25	.	.	PUNCT
admet-544	67	1	they	they	PRON
admet-544	67	2	also	also	ADV
admet-544	67	3	determined	determine	VERB
admet-544	67	4	that	that	SCONJ
admet-544	67	5	the	the	DET
admet-544	67	6	amino	amino	NOUN
admet-544	67	7	acid	acid	NOUN
admet-544	67	8	contributions	contribution	NOUN
admet-544	67	9	depended	depend	VERB
admet-544	67	10	on	on	ADP
admet-544	67	11	the	the	DET
admet-544	67	12	location	location	NOUN
admet-544	67	13	of	of	ADP
admet-544	67	14	the	the	DET
admet-544	67	15	amino	amino	NOUN
admet-544	67	16	acid	acid	NOUN
admet-544	67	17	in	in	ADP
admet-544	67	18	the	the	DET
admet-544	67	19	sequence	sequence	NOUN
admet-544	67	20	.	.	PUNCT
admet-544	68	1	in	in	ADP
admet-544	68	2	this	this	DET
admet-544	68	3	paper	paper	NOUN
admet-544	68	4	,	,	PUNCT
admet-544	68	5	we	we	PRON
admet-544	68	6	have	have	AUX
admet-544	68	7	investigated	investigate	VERB
admet-544	68	8	the	the	DET
admet-544	68	9	retention	retention	NOUN
admet-544	68	10	behaviour	behaviour	NOUN
admet-544	68	11	of	of	ADP
admet-544	68	12	20	20	NUM
admet-544	68	13	potential	potential	ADJ
admet-544	68	14	peptide	peptide	NOUN
admet-544	68	15	therapeutics	therapeutic	NOUN
admet-544	68	16	,	,	PUNCT
admet-544	68	17	(	(	PUNCT
admet-544	68	18	one	one	NUM
admet-544	68	19	of	of	ADP
admet-544	68	20	them	they	PRON
admet-544	68	21	has	have	AUX
admet-544	68	22	been	be	AUX
admet-544	68	23	tested	test	VERB
admet-544	68	24	in	in	ADP
admet-544	68	25	vivo	vivo	NOUN
admet-544	68	26	)	)	PUNCT
admet-544	68	27	including	include	VERB
admet-544	68	28	linear	linear	NOUN
admet-544	68	29	and	and	CCONJ
admet-544	68	30	bicyclic	bicyclic	ADJ
admet-544	68	31	peptides	peptide	NOUN
admet-544	68	32	on	on	ADP
admet-544	68	33	reversed	reverse	VERB
admet-544	68	34	-	-	PUNCT
admet-544	68	35	phase	phase	NOUN
admet-544	68	36	and	and	CCONJ
admet-544	68	37	biomimetic	biomimetic	ADJ
admet-544	68	38	hplc	hplc	NOUN
admet-544	68	39	stationary	stationary	ADJ
admet-544	68	40	phases	phase	NOUN
admet-544	68	41	such	such	ADJ
admet-544	68	42	as	as	ADP
admet-544	68	43	human	human	ADJ
admet-544	68	44	serum	serum	NOUN
admet-544	68	45	albumin	albumin	PROPN
admet-544	68	46	(	(	PUNCT
admet-544	68	47	hsa	hsa	PROPN
admet-544	68	48	)	)	PUNCT
admet-544	68	49	,	,	PUNCT
admet-544	68	50	alpha-1	alpha-1	NOUN
admet-544	68	51	-	-	PUNCT
admet-544	68	52	acid	acid	NOUN
admet-544	68	53	-	-	PUNCT
admet-544	68	54	glycoprotein	glycoprotein	NOUN
admet-544	68	55	(	(	PUNCT
admet-544	68	56	agp	agp	NOUN
admet-544	68	57	)	)	PUNCT
admet-544	68	58	and	and	CCONJ
admet-544	68	59	iam	iam	PROPN
admet-544	68	60	phases	phase	NOUN
admet-544	68	61	[	[	X
admet-544	68	62	14,30,32	14,30,32	NUM
admet-544	68	63	]	]	PUNCT
admet-544	68	64	.	.	PUNCT
admet-544	69	1	the	the	DET
admet-544	69	2	measured	measure	VERB
admet-544	69	3	properties	property	NOUN
admet-544	69	4	have	have	AUX
admet-544	69	5	been	be	AUX
admet-544	69	6	analysed	analyse	VERB
admet-544	69	7	in	in	ADP
admet-544	69	8	comparison	comparison	NOUN
admet-544	69	9	to	to	ADP
admet-544	69	10	marketed	market	VERB
admet-544	69	11	drugs	drug	NOUN
admet-544	69	12	’	'	PUNCT
admet-544	69	13	properties	property	NOUN
admet-544	69	14	.	.	PUNCT
admet-544	70	1	the	the	DET
admet-544	70	2	models	model	NOUN
admet-544	70	3	developed	develop	VERB
admet-544	70	4	for	for	ADP
admet-544	70	5	small	small	ADJ
admet-544	70	6	molecules	molecule	NOUN
admet-544	70	7	have	have	AUX
admet-544	70	8	been	be	AUX
admet-544	70	9	applied	apply	VERB
admet-544	70	10	to	to	ADP
admet-544	70	11	the	the	DET
admet-544	70	12	peptides	peptide	NOUN
admet-544	70	13	to	to	PART
admet-544	70	14	predict	predict	VERB
admet-544	70	15	in	in	ADP
admet-544	70	16	vivo	vivo	ADJ
admet-544	70	17	distribution	distribution	NOUN
admet-544	70	18	and	and	CCONJ
admet-544	70	19	cell	cell	NOUN
admet-544	70	20	penetration	penetration	NOUN
admet-544	70	21	.	.	PUNCT
admet-544	71	1	experimental	experimental	ADJ
admet-544	71	2	all	all	DET
admet-544	71	3	chromatographic	chromatographic	ADJ
admet-544	71	4	measurements	measurement	NOUN
admet-544	71	5	were	be	AUX
admet-544	71	6	carried	carry	VERB
admet-544	71	7	out	out	ADP
admet-544	71	8	on	on	ADP
admet-544	71	9	an	an	DET
admet-544	71	10	agilent	agilent	PROPN
admet-544	71	11	1100	1100	NUM
admet-544	71	12	series	series	PROPN
admet-544	71	13	hplc	hplc	PROPN
admet-544	71	14	equipped	equip	VERB
admet-544	71	15	with	with	ADP
admet-544	71	16	a	a	DET
admet-544	71	17	uv	uv	NOUN
admet-544	71	18	-	-	PUNCT
admet-544	71	19	diode	diode	NOUN
admet-544	71	20	array	array	NOUN
admet-544	71	21	detector	detector	NOUN
admet-544	71	22	.	.	PUNCT
admet-544	72	1	lipophilicity	lipophilicity	NOUN
admet-544	72	2	measurements	measurement	NOUN
admet-544	72	3	using	use	VERB
admet-544	72	4	c-18	c-18	PROPN
admet-544	72	5	stationary	stationary	ADJ
admet-544	72	6	phase	phase	NOUN
admet-544	72	7	with	with	ADP
admet-544	72	8	acidic	acidic	ADJ
admet-544	72	9	,	,	PUNCT
admet-544	72	10	neutral	neutral	ADJ
admet-544	72	11	and	and	CCONJ
admet-544	72	12	basic	basic	ADJ
admet-544	72	13	phs	phs	NOUN
admet-544	72	14	the	the	DET
admet-544	72	15	reversed	reverse	VERB
admet-544	72	16	phase	phase	NOUN
admet-544	72	17	fast	fast	ADJ
admet-544	72	18	gradient	gradient	NOUN
admet-544	72	19	retention	retention	NOUN
admet-544	72	20	times	time	NOUN
admet-544	72	21	have	have	AUX
admet-544	72	22	been	be	AUX
admet-544	72	23	measured	measure	VERB
admet-544	72	24	using	use	VERB
admet-544	72	25	a	a	DET
admet-544	72	26	gemini	gemini	NOUN
admet-544	72	27	nt	nt	PROPN
admet-544	72	28	c-18	c-18	PROPN
admet-544	72	29	column	column	NOUN
admet-544	72	30	with	with	ADP
admet-544	72	31	the	the	DET
admet-544	72	32	dimensions	dimension	NOUN
admet-544	72	33	of	of	ADP
admet-544	72	34	50	50	NUM
admet-544	72	35	x	x	SYM
admet-544	72	36	3	3	NUM
admet-544	72	37	mm	mm	NOUN
admet-544	72	38	,	,	PUNCT
admet-544	72	39	particle	particle	NOUN
admet-544	72	40	size	size	NOUN
admet-544	72	41	5	5	NUM
admet-544	72	42	µm	µm	NOUN
admet-544	72	43	with	with	ADP
admet-544	72	44	a	a	DET
admet-544	72	45	110	110	NUM
admet-544	72	46	å	å	PRON
admet-544	72	47	pore	pore	ADJ
admet-544	72	48	size	size	NOUN
admet-544	72	49	(	(	PUNCT
admet-544	72	50	phenomenex	phenomenex	ADV
admet-544	72	51	uk	uk	PROPN
admet-544	72	52	)	)	PUNCT
admet-544	72	53	.	.	PUNCT
admet-544	73	1	the	the	DET
admet-544	73	2	starting	start	VERB
admet-544	73	3	mobile	mobile	ADJ
admet-544	73	4	phase	phase	NOUN
admet-544	73	5	was	be	AUX
admet-544	73	6	0.01	0.01	NUM
admet-544	73	7	m	m	NOUN
admet-544	73	8	formic	formic	ADJ
admet-544	73	9	acid	acid	NOUN
admet-544	73	10	at	at	ADP
admet-544	73	11	ph	ph	PROPN
admet-544	73	12	2.6	2.6	NUM
admet-544	73	13	for	for	ADP
admet-544	73	14	low	low	ADJ
admet-544	73	15	ph	ph	ADJ
admet-544	73	16	lipophilicity	lipophilicity	NOUN
admet-544	73	17	,	,	PUNCT
admet-544	73	18	50	50	NUM
admet-544	73	19	mm	mm	NOUN
admet-544	73	20	ammonium	ammonium	NOUN
admet-544	73	21	acetate	acetate	NOUN
admet-544	73	22	buffers	buffer	NOUN
admet-544	73	23	with	with	ADP
admet-544	73	24	ph	ph	PROPN
admet-544	73	25	adjusted	adjust	VERB
admet-544	73	26	to	to	ADP
admet-544	73	27	7.4	7.4	NUM
admet-544	73	28	and	and	CCONJ
admet-544	73	29	10.5	10.5	NUM
admet-544	73	30	by	by	ADP
admet-544	73	31	concentrated	concentrated	ADJ
admet-544	73	32	ammonia	ammonia	NOUN
admet-544	73	33	solution	solution	NOUN
admet-544	73	34	for	for	ADP
admet-544	73	35	neutral	neutral	ADJ
admet-544	73	36	and	and	CCONJ
admet-544	73	37	basic	basic	ADJ
admet-544	73	38	ph	ph	ADJ
admet-544	73	39	lipophilicity	lipophilicity	NOUN
admet-544	73	40	admet	admet	X
admet-544	73	41	&	&	CCONJ
admet-544	73	42	dmpk	dmpk	PROPN
admet-544	73	43	6(2	6(2	NUM
admet-544	73	44	)	)	PUNCT
admet-544	73	45	(	(	PUNCT
admet-544	73	46	2018	2018	NUM
admet-544	73	47	)	)	PUNCT
admet-544	73	48	162	162	NUM
admet-544	73	49	-	-	SYM
admet-544	73	50	175	175	NUM
admet-544	73	51	biomimetic	biomimetic	ADJ
admet-544	73	52	hplc	hplc	NOUN
admet-544	73	53	in	in	ADP
admet-544	73	54	the	the	DET
admet-544	73	55	estimation	estimation	NOUN
admet-544	73	56	of	of	ADP
admet-544	73	57	physchem	physchem	NOUN
admet-544	73	58	properties	property	NOUN
admet-544	73	59	of	of	ADP
admet-544	73	60	peptides	peptide	NOUN
admet-544	73	61	doi	doi	NOUN
admet-544	73	62	:	:	PUNCT
admet-544	73	63	10.5599	10.5599	NUM
admet-544	73	64	/	/	SYM
admet-544	73	65	admet.544	admet.544	PROPN
admet-544	73	66	165	165	NUM
admet-544	73	67	measurements	measurement	NOUN
admet-544	73	68	,	,	PUNCT
admet-544	73	69	respectively	respectively	ADV
admet-544	73	70	.	.	PUNCT
admet-544	74	1	all	all	DET
admet-544	74	2	reagents	reagent	NOUN
admet-544	74	3	were	be	AUX
admet-544	74	4	hplc	hplc	NOUN
admet-544	74	5	grade	grade	NOUN
admet-544	74	6	obtained	obtain	VERB
admet-544	74	7	from	from	ADP
admet-544	74	8	honeywell	honeywell	PROPN
admet-544	74	9	/	/	SYM
admet-544	74	10	sigma	sigma	PROPN
admet-544	74	11	-	-	PUNCT
admet-544	74	12	aldrich	aldrich	PROPN
admet-544	74	13	,	,	PUNCT
admet-544	74	14	germany	germany	PROPN
admet-544	74	15	.	.	PUNCT
admet-544	75	1	a	a	DET
admet-544	75	2	1.00	1.00	NUM
admet-544	75	3	ml	ml	NOUN
admet-544	75	4	/	/	SYM
admet-544	75	5	min	min	NOUN
admet-544	75	6	flow	flow	NOUN
admet-544	75	7	rate	rate	NOUN
admet-544	75	8	was	be	AUX
admet-544	75	9	applied	apply	VERB
admet-544	75	10	.	.	PUNCT
admet-544	76	1	the	the	DET
admet-544	76	2	acetonitrile	acetonitrile	ADJ
admet-544	76	3	gradient	gradient	NOUN
admet-544	76	4	was	be	AUX
admet-544	76	5	from	from	ADP
admet-544	76	6	0	0	NUM
admet-544	76	7	to	to	PART
admet-544	76	8	100	100	NUM
admet-544	76	9	%	%	NOUN
admet-544	76	10	from	from	ADP
admet-544	76	11	0	0	NUM
admet-544	76	12	to	to	ADP
admet-544	76	13	3.5	3.5	NUM
admet-544	76	14	min	min	NOUN
admet-544	76	15	then	then	ADV
admet-544	76	16	100	100	NUM
admet-544	76	17	%	%	NOUN
admet-544	76	18	acetonitrile	acetonitrile	NOUN
admet-544	76	19	was	be	AUX
admet-544	76	20	kept	keep	VERB
admet-544	76	21	until	until	ADP
admet-544	76	22	4.5	4.5	NUM
admet-544	76	23	min	min	NOUN
admet-544	76	24	and	and	CCONJ
admet-544	76	25	then	then	ADV
admet-544	76	26	returned	return	VERB
admet-544	76	27	to	to	ADP
admet-544	76	28	0	0	NUM
admet-544	76	29	%	%	NOUN
admet-544	76	30	at	at	ADP
admet-544	76	31	4.7	4.7	NUM
admet-544	76	32	min	min	NOUN
admet-544	76	33	.	.	PUNCT
admet-544	77	1	the	the	DET
admet-544	77	2	run	run	NOUN
admet-544	77	3	time	time	NOUN
admet-544	77	4	was	be	AUX
admet-544	77	5	6	6	NUM
admet-544	77	6	min	min	NOUN
admet-544	77	7	.	.	PROPN
admet-544	77	8	hplc	hplc	PROPN
admet-544	77	9	grade	grade	NOUN
admet-544	77	10	water	water	NOUN
admet-544	77	11	and	and	CCONJ
admet-544	77	12	acetonitrile	acetonitrile	NOUN
admet-544	77	13	were	be	AUX
admet-544	77	14	obtained	obtain	VERB
admet-544	77	15	from	from	ADP
admet-544	77	16	rathburn	rathburn	PROPN
admet-544	77	17	chemicals	chemicals	PROPN
admet-544	77	18	ltd	ltd	PROPN
admet-544	77	19	,	,	PUNCT
admet-544	77	20	walkerburn	walkerburn	NOUN
admet-544	77	21	,	,	PUNCT
admet-544	77	22	uk	uk	PROPN
admet-544	77	23	.	.	PUNCT
admet-544	78	1	the	the	DET
admet-544	78	2	gradient	gradient	ADJ
admet-544	78	3	retention	retention	NOUN
admet-544	78	4	times	time	NOUN
admet-544	78	5	were	be	AUX
admet-544	78	6	standardized	standardize	VERB
admet-544	78	7	using	use	VERB
admet-544	78	8	the	the	DET
admet-544	78	9	valko	valko	ADJ
admet-544	78	10	test	test	NOUN
admet-544	78	11	mixture	mixture	NOUN
admet-544	78	12	and	and	CCONJ
admet-544	78	13	the	the	DET
admet-544	78	14	chromatographic	chromatographic	ADJ
admet-544	78	15	hydrophobicity	hydrophobicity	NOUN
admet-544	78	16	index	index	NOUN
admet-544	78	17	(	(	PUNCT
admet-544	78	18	chi	chi	NOUN
admet-544	78	19	)	)	PUNCT
admet-544	78	20	values	value	NOUN
admet-544	78	21	as	as	SCONJ
admet-544	78	22	described	describe	VERB
admet-544	78	23	previously	previously	ADV
admet-544	78	24	[	[	X
admet-544	78	25	14,32	14,32	NUM
admet-544	78	26	]	]	PUNCT
admet-544	78	27	.	.	PUNCT
admet-544	79	1	the	the	DET
admet-544	79	2	chi	chi	PROPN
admet-544	79	3	values	value	NOUN
admet-544	79	4	were	be	AUX
admet-544	79	5	converted	convert	VERB
admet-544	79	6	to	to	ADP
admet-544	79	7	the	the	DET
admet-544	79	8	octanol	octanol	NOUN
admet-544	79	9	/	/	SYM
admet-544	79	10	water	water	NOUN
admet-544	79	11	log	log	NOUN
admet-544	79	12	d	d	NOUN
admet-544	79	13	scale	scale	NOUN
admet-544	79	14	using	use	VERB
admet-544	79	15	equation	equation	NOUN
admet-544	79	16	1	1	NUM
admet-544	79	17	.	.	PUNCT
admet-544	80	1	chi	chi	PROPN
admet-544	80	2	log	log	PROPN
admet-544	80	3	d	d	NOUN
admet-544	80	4	=	=	SYM
admet-544	80	5	0.0525	0.0525	NUM
admet-544	80	6	chi	chi	NOUN
admet-544	80	7	–	–	PUNCT
admet-544	80	8	1.467	1.467	NUM
admet-544	80	9	(	(	PUNCT
admet-544	80	10	1	1	NUM
admet-544	80	11	)	)	PUNCT
admet-544	80	12	in	in	ADP
admet-544	80	13	this	this	DET
admet-544	80	14	way	way	NOUN
admet-544	80	15	,	,	PUNCT
admet-544	80	16	the	the	DET
admet-544	80	17	peptides	peptide	NOUN
admet-544	80	18	lipophilicity	lipophilicity	NOUN
admet-544	80	19	can	can	AUX
admet-544	80	20	be	be	AUX
admet-544	80	21	compared	compare	VERB
admet-544	80	22	to	to	ADP
admet-544	80	23	their	their	PRON
admet-544	80	24	octanol	octanol	NOUN
admet-544	80	25	/	/	SYM
admet-544	80	26	water	water	NOUN
admet-544	80	27	lipophilicity	lipophilicity	NOUN
admet-544	80	28	.	.	PUNCT
admet-544	81	1	measurements	measurement	NOUN
admet-544	81	2	of	of	ADP
admet-544	81	3	membrane	membrane	NOUN
admet-544	81	4	binding	binding	NOUN
admet-544	81	5	using	use	VERB
admet-544	81	6	immobilized	immobilized	ADJ
admet-544	81	7	artificial	artificial	ADJ
admet-544	81	8	membrane	membrane	NOUN
admet-544	81	9	(	(	PUNCT
admet-544	81	10	iam	iam	PROPN
admet-544	81	11	)	)	PUNCT
admet-544	81	12	chromatography	chromatography	NOUN
admet-544	81	13	for	for	ADP
admet-544	81	14	the	the	DET
admet-544	81	15	measurements	measurement	NOUN
admet-544	81	16	of	of	ADP
admet-544	81	17	the	the	DET
admet-544	81	18	peptides	peptide	NOUN
admet-544	81	19	interactions	interaction	NOUN
admet-544	81	20	with	with	ADP
admet-544	81	21	phospholipids	phospholipid	NOUN
admet-544	81	22	,	,	PUNCT
admet-544	81	23	the	the	DET
admet-544	81	24	gradient	gradient	ADJ
admet-544	81	25	retention	retention	NOUN
admet-544	81	26	times	time	NOUN
admet-544	81	27	of	of	ADP
admet-544	81	28	the	the	DET
admet-544	81	29	peptides	peptide	NOUN
admet-544	81	30	have	have	AUX
admet-544	81	31	been	be	AUX
admet-544	81	32	measured	measure	VERB
admet-544	81	33	using	use	VERB
admet-544	81	34	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	81	35	100	100	NUM
admet-544	81	36	x	x	SYM
admet-544	81	37	4.6	4.6	NUM
admet-544	81	38	mm	mm	NOUN
admet-544	81	39	column	column	NOUN
admet-544	81	40	with	with	ADP
admet-544	81	41	10	10	NUM
admet-544	81	42	µm	µm	ADP
admet-544	81	43	diameter	diameter	NOUN
admet-544	81	44	and	and	CCONJ
admet-544	81	45	300	300	NUM
admet-544	81	46	å	å	NOUN
admet-544	81	47	pore	pore	ADJ
admet-544	81	48	size	size	NOUN
admet-544	81	49	particles	particle	NOUN
admet-544	81	50	.	.	PUNCT
admet-544	82	1	the	the	DET
admet-544	82	2	starting	start	VERB
admet-544	82	3	mobile	mobile	ADJ
admet-544	82	4	phase	phase	NOUN
admet-544	82	5	was	be	AUX
admet-544	82	6	50	50	NUM
admet-544	82	7	mm	mm	NOUN
admet-544	82	8	ammonium	ammonium	NOUN
admet-544	82	9	acetate	acetate	NOUN
admet-544	82	10	with	with	ADP
admet-544	82	11	the	the	DET
admet-544	82	12	ph	ph	NOUN
admet-544	82	13	adjusted	adjust	VERB
admet-544	82	14	to	to	ADP
admet-544	82	15	7.4	7.4	NUM
admet-544	82	16	.	.	PUNCT
admet-544	83	1	the	the	DET
admet-544	83	2	acetonitrile	acetonitrile	ADJ
admet-544	83	3	gradient	gradient	NOUN
admet-544	83	4	was	be	AUX
admet-544	83	5	applied	apply	VERB
admet-544	83	6	from	from	ADP
admet-544	83	7	0	0	NUM
admet-544	83	8	to	to	PART
admet-544	83	9	90	90	NUM
admet-544	83	10	%	%	NOUN
admet-544	83	11	from	from	ADP
admet-544	83	12	0	0	NUM
admet-544	83	13	to	to	ADP
admet-544	83	14	4.75	4.75	NUM
admet-544	83	15	min	min	NOUN
admet-544	83	16	and	and	CCONJ
admet-544	83	17	kept	keep	VERB
admet-544	83	18	at	at	ADP
admet-544	83	19	90	90	NUM
admet-544	83	20	%	%	NOUN
admet-544	83	21	until	until	ADP
admet-544	83	22	5.25	5.25	NUM
admet-544	83	23	min	min	NOUN
admet-544	83	24	.	.	PROPN
admet-544	83	25	from	from	ADP
admet-544	83	26	5.25	5.25	NUM
admet-544	83	27	to	to	ADP
admet-544	83	28	5.5	5.5	NUM
admet-544	83	29	min	min	NOUN
admet-544	83	30	the	the	DET
admet-544	83	31	acetonitrile	acetonitrile	ADJ
admet-544	83	32	concentration	concentration	NOUN
admet-544	83	33	was	be	AUX
admet-544	83	34	dropped	drop	VERB
admet-544	83	35	to	to	ADP
admet-544	83	36	0	0	NUM
admet-544	83	37	.	.	PUNCT
admet-544	84	1	the	the	DET
admet-544	84	2	mobile	mobile	ADJ
admet-544	84	3	phase	phase	NOUN
admet-544	84	4	flow	flow	NOUN
admet-544	84	5	rate	rate	NOUN
admet-544	84	6	was	be	AUX
admet-544	84	7	1.5	1.5	NUM
admet-544	84	8	ml	ml	NOUN
admet-544	84	9	/	/	SYM
admet-544	84	10	min	min	NOUN
admet-544	84	11	and	and	CCONJ
admet-544	84	12	the	the	DET
admet-544	84	13	run	run	NOUN
admet-544	84	14	time	time	NOUN
admet-544	84	15	was	be	AUX
admet-544	84	16	6	6	NUM
admet-544	84	17	min	min	NOUN
admet-544	84	18	.	.	PUNCT
admet-544	85	1	the	the	DET
admet-544	85	2	retention	retention	NOUN
admet-544	85	3	times	time	NOUN
admet-544	85	4	were	be	AUX
admet-544	85	5	standardized	standardize	VERB
admet-544	85	6	using	use	VERB
admet-544	85	7	the	the	DET
admet-544	85	8	iam	iam	PROPN
admet-544	85	9	calibration	calibration	NOUN
admet-544	85	10	mixture	mixture	NOUN
admet-544	85	11	as	as	SCONJ
admet-544	85	12	described	describe	VERB
admet-544	85	13	previously	previously	ADV
admet-544	85	14	[	[	X
admet-544	85	15	33	33	NUM
admet-544	85	16	]	]	PUNCT
admet-544	85	17	.	.	PUNCT
admet-544	86	1	the	the	DET
admet-544	86	2	natural	natural	ADJ
admet-544	86	3	state	state	NOUN
admet-544	86	4	of	of	ADP
admet-544	86	5	the	the	DET
admet-544	86	6	phosphatidyl	phosphatidyl	PROPN
admet-544	86	7	choline	choline	NOUN
admet-544	86	8	headgroup	headgroup	NOUN
admet-544	86	9	on	on	ADP
admet-544	86	10	the	the	DET
admet-544	86	11	iam	iam	PROPN
admet-544	86	12	stationary	stationary	ADJ
admet-544	86	13	phase	phase	NOUN
admet-544	86	14	was	be	AUX
admet-544	86	15	tested	test	VERB
admet-544	86	16	using	use	VERB
admet-544	86	17	the	the	DET
admet-544	86	18	six	six	NUM
admet-544	86	19	system	system	NOUN
admet-544	86	20	suitability	suitability	NOUN
admet-544	86	21	test	test	NOUN
admet-544	86	22	compounds	compound	NOUN
admet-544	86	23	listed	list	VERB
admet-544	86	24	in	in	ADP
admet-544	86	25	table	table	NOUN
admet-544	86	26	1	1	NUM
admet-544	86	27	.	.	PUNCT
admet-544	87	1	the	the	DET
admet-544	87	2	chi	chi	PROPN
admet-544	87	3	iam	iam	PROPN
admet-544	87	4	values	value	NOUN
admet-544	87	5	were	be	AUX
admet-544	87	6	converted	convert	VERB
admet-544	87	7	to	to	ADP
admet-544	87	8	the	the	DET
admet-544	87	9	octanol	octanol	NOUN
admet-544	87	10	/	/	SYM
admet-544	87	11	water	water	NOUN
admet-544	87	12	scale	scale	NOUN
admet-544	87	13	using	use	VERB
admet-544	87	14	equation	equation	NOUN
admet-544	87	15	2	2	NUM
admet-544	87	16	[	[	X
admet-544	87	17	33	33	NUM
admet-544	87	18	]	]	PUNCT
admet-544	87	19	.	.	PUNCT
admet-544	88	1	log	log	PROPN
admet-544	88	2	kiam	kiam	PROPN
admet-544	89	1	=	=	PUNCT
admet-544	89	2	0.29*exp(0.046	0.29*exp(0.046	NOUN
admet-544	89	3	chi	chi	NOUN
admet-544	89	4	iam+0.42	iam+0.42	PROPN
admet-544	89	5	)	)	PUNCT
admet-544	89	6	+	+	CCONJ
admet-544	89	7	0.70	0.70	NUM
admet-544	89	8	(	(	PUNCT
admet-544	89	9	2	2	NUM
admet-544	89	10	)	)	PUNCT
admet-544	89	11	the	the	DET
admet-544	89	12	log	log	NOUN
admet-544	89	13	kiam	kiam	PROPN
admet-544	89	14	values	value	NOUN
admet-544	89	15	express	express	VERB
admet-544	89	16	the	the	DET
admet-544	89	17	membrane	membrane	NOUN
admet-544	89	18	partition	partition	NOUN
admet-544	89	19	comparable	comparable	ADJ
admet-544	89	20	to	to	ADP
admet-544	89	21	the	the	DET
admet-544	89	22	octanol	octanol	NOUN
admet-544	89	23	/	/	SYM
admet-544	89	24	water	water	NOUN
admet-544	89	25	lipophilicity	lipophilicity	NOUN
admet-544	89	26	.	.	PUNCT
admet-544	90	1	table	table	NOUN
admet-544	90	2	1	1	NUM
admet-544	90	3	.	.	PUNCT
admet-544	91	1	the	the	DET
admet-544	91	2	iam	iam	PROPN
admet-544	91	3	system	system	NOUN
admet-544	91	4	suitability	suitability	NOUN
admet-544	91	5	test	test	NOUN
admet-544	91	6	compounds	compound	NOUN
admet-544	91	7	and	and	CCONJ
admet-544	91	8	their	their	PRON
admet-544	91	9	expected	expect	VERB
admet-544	91	10	chi	chi	PROPN
admet-544	91	11	iam	iam	PROPN
admet-544	91	12	values	value	VERB
admet-544	91	13	[	[	X
admet-544	91	14	14	14	NUM
admet-544	91	15	]	]	PUNCT
admet-544	91	16	.	.	PUNCT
admet-544	92	1	compound	compound	NOUN
admet-544	92	2	acid	acid	NOUN
admet-544	92	3	/	/	SYM
admet-544	92	4	base	base	NOUN
admet-544	92	5	typical	typical	ADJ
admet-544	92	6	retention	retention	NOUN
admet-544	92	7	time	time	NOUN
admet-544	92	8	(	(	PUNCT
admet-544	92	9	min	min	NOUN
admet-544	92	10	)	)	PUNCT
admet-544	92	11	chi	chi	PROPN
admet-544	92	12	iam	iam	PROPN
admet-544	92	13	carbamazepine	carbamazepine	VERB
admet-544	92	14	neutral	neutral	ADJ
admet-544	92	15	2.98	2.98	NUM
admet-544	92	16	22.3	22.3	NUM
admet-544	92	17	colchicin	colchicin	NOUN
admet-544	92	18	neutral	neutral	ADJ
admet-544	92	19	3.31	3.31	NUM
admet-544	92	20	28.0	28.0	NUM
admet-544	92	21	warfarin	warfarin	NOUN
admet-544	92	22	acidic	acidic	ADJ
admet-544	92	23	2.62	2.62	NUM
admet-544	92	24	16.4	16.4	NUM
admet-544	92	25	indomethacin	indomethacin	NOUN
admet-544	92	26	acidic	acidic	ADJ
admet-544	92	27	3.15	3.15	NUM
admet-544	92	28	25.3	25.3	NUM
admet-544	92	29	nicardipine	nicardipine	NOUN
admet-544	92	30	basic	basic	ADJ
admet-544	92	31	4.38	4.38	NUM
admet-544	92	32	46.1	46.1	NUM
admet-544	92	33	propranolol	propranolol	NOUN
admet-544	92	34	basic	basic	ADJ
admet-544	92	35	4.72	4.72	NUM
admet-544	92	36	51.9	51.9	NUM
admet-544	92	37	protein	protein	NOUN
admet-544	92	38	binding	bind	VERB
admet-544	92	39	measurements	measurement	NOUN
admet-544	92	40	using	use	VERB
admet-544	92	41	biomimetic	biomimetic	ADJ
admet-544	92	42	protein	protein	NOUN
admet-544	92	43	stationary	stationary	ADJ
admet-544	92	44	phases	phase	NOUN
admet-544	92	45	the	the	DET
admet-544	92	46	peptides	peptide	NOUN
admet-544	92	47	interactions	interaction	NOUN
admet-544	92	48	with	with	ADP
admet-544	92	49	hsa	hsa	PROPN
admet-544	92	50	and	and	CCONJ
admet-544	92	51	agp	agp	NOUN
admet-544	92	52	have	have	AUX
admet-544	92	53	been	be	AUX
admet-544	92	54	measured	measure	VERB
admet-544	92	55	using	use	VERB
admet-544	92	56	commercially	commercially	ADV
admet-544	92	57	available	available	ADJ
admet-544	92	58	chemically	chemically	ADV
admet-544	92	59	bonded	bond	VERB
admet-544	92	60	hsa	hsa	PROPN
admet-544	92	61	(	(	PUNCT
admet-544	92	62	chiralpak	chiralpak	NOUN
admet-544	92	63	-	-	PUNCT
admet-544	92	64	hsa	hsa	NOUN
admet-544	92	65	)	)	PUNCT
admet-544	92	66	and	and	CCONJ
admet-544	92	67	agp	agp	PROPN
admet-544	92	68	(	(	PUNCT
admet-544	92	69	chiralpak	chiralpak	ADJ
admet-544	92	70	-	-	ADJ
admet-544	92	71	agp	agp	NOUN
admet-544	92	72	)	)	PUNCT
admet-544	92	73	hplc	hplc	NOUN
admet-544	92	74	columns	column	NOUN
admet-544	92	75	with	with	ADP
admet-544	92	76	the	the	DET
admet-544	92	77	dimensions	dimension	NOUN
admet-544	92	78	of	of	ADP
admet-544	92	79	50	50	NUM
admet-544	92	80	x	x	SYM
admet-544	92	81	3	3	NUM
admet-544	92	82	mm	mm	NOUN
admet-544	92	83	with	with	ADP
admet-544	92	84	5	5	NUM
admet-544	92	85	µm	µm	ADP
admet-544	92	86	particle	particle	NOUN
admet-544	92	87	size	size	NOUN
admet-544	92	88	obtained	obtain	VERB
admet-544	92	89	from	from	ADP
admet-544	92	90	hichrom	hichrom	ADP
admet-544	92	91	ltd	ltd	PROPN
admet-544	92	92	,	,	PUNCT
admet-544	92	93	reading	reading	NOUN
admet-544	92	94	,	,	PUNCT
admet-544	92	95	uk	uk	PROPN
admet-544	92	96	.	.	PUNCT
admet-544	93	1	the	the	DET
admet-544	93	2	mobile	mobile	ADJ
admet-544	93	3	phase	phase	NOUN
admet-544	93	4	was	be	AUX
admet-544	93	5	50	50	NUM
admet-544	93	6	mm	mm	NOUN
admet-544	93	7	ammonium	ammonium	NOUN
admet-544	93	8	acetate	acetate	NOUN
admet-544	93	9	with	with	ADP
admet-544	93	10	the	the	DET
admet-544	93	11	ph	ph	NOUN
admet-544	93	12	adjusted	adjust	VERB
admet-544	93	13	to	to	ADP
admet-544	93	14	7.4	7.4	NUM
admet-544	93	15	.	.	PUNCT
admet-544	94	1	an	an	DET
admet-544	94	2	iso	iso	NOUN
admet-544	94	3	-	-	PUNCT
admet-544	94	4	propanol	propanol	NOUN
admet-544	94	5	gradient	gradient	NOUN
admet-544	94	6	(	(	PUNCT
admet-544	94	7	hplc	hplc	NOUN
admet-544	94	8	grade	grade	NOUN
admet-544	94	9	,	,	PUNCT
admet-544	94	10	rathburn	rathburn	NOUN
admet-544	94	11	chemicals	chemical	NOUN
admet-544	94	12	,	,	PUNCT
admet-544	94	13	walkerburn	walkerburn	NOUN
admet-544	94	14	,	,	PUNCT
admet-544	94	15	uk	uk	PROPN
admet-544	94	16	)	)	PUNCT
admet-544	94	17	was	be	AUX
admet-544	94	18	used	use	VERB
admet-544	94	19	from	from	ADP
admet-544	94	20	0	0	NUM
admet-544	94	21	to	to	ADP
admet-544	94	22	35	35	NUM
admet-544	94	23	%	%	NOUN
admet-544	94	24	from	from	ADP
admet-544	94	25	0	0	NUM
admet-544	94	26	to	to	ADP
admet-544	94	27	3.5	3.5	NUM
admet-544	94	28	min	min	NOUN
admet-544	94	29	with	with	ADP
admet-544	94	30	a	a	DET
admet-544	94	31	flow	flow	NOUN
admet-544	94	32	rate	rate	NOUN
admet-544	94	33	of	of	ADP
admet-544	94	34	1.5	1.5	NUM
admet-544	94	35	ml	ml	NOUN
admet-544	94	36	/	/	SYM
admet-544	94	37	min	min	NOUN
admet-544	94	38	.	.	PUNCT
admet-544	94	39	the	the	DET
admet-544	94	40	35	35	NUM
admet-544	94	41	%	%	NOUN
admet-544	94	42	iso	iso	NOUN
admet-544	94	43	-	-	PUNCT
admet-544	94	44	propanol	propanol	ADJ
admet-544	94	45	mobile	mobile	ADJ
admet-544	94	46	phase	phase	NOUN
admet-544	94	47	was	be	AUX
admet-544	94	48	run	run	VERB
admet-544	94	49	till	till	SCONJ
admet-544	94	50	4.5	4.5	NUM
admet-544	94	51	min	min	NOUN
admet-544	94	52	and	and	CCONJ
admet-544	94	53	then	then	ADV
admet-544	94	54	back	back	ADV
admet-544	94	55	to	to	ADP
admet-544	94	56	0	0	NUM
admet-544	94	57	%	%	NOUN
admet-544	94	58	within	within	ADP
admet-544	94	59	0.2	0.2	NUM
admet-544	94	60	min	min	NOUN
admet-544	94	61	.	.	PUNCT
admet-544	95	1	the	the	DET
admet-544	95	2	run	run	NOUN
admet-544	95	3	time	time	NOUN
admet-544	95	4	was	be	AUX
admet-544	95	5	6	6	NUM
admet-544	95	6	min	min	NOUN
admet-544	95	7	to	to	PART
admet-544	95	8	allow	allow	VERB
admet-544	95	9	re	re	VERB
admet-544	95	10	-	-	NOUN
admet-544	95	11	equilibrate	equilibrate	NOUN
admet-544	95	12	of	of	ADP
admet-544	95	13	the	the	DET
admet-544	95	14	protein	protein	NOUN
admet-544	95	15	phase	phase	NOUN
admet-544	95	16	with	with	ADP
admet-544	95	17	the	the	DET
admet-544	95	18	buffer	buffer	NOUN
admet-544	95	19	.	.	PUNCT
admet-544	96	1	the	the	DET
admet-544	96	2	retention	retention	NOUN
admet-544	96	3	times	time	NOUN
admet-544	96	4	were	be	AUX
admet-544	96	5	standardized	standardize	VERB
admet-544	96	6	using	use	VERB
admet-544	96	7	the	the	DET
admet-544	96	8	calibration	calibration	NOUN
admet-544	96	9	set	set	NOUN
admet-544	96	10	of	of	ADP
admet-544	96	11	compounds	compound	NOUN
admet-544	96	12	as	as	SCONJ
admet-544	96	13	described	describe	VERB
admet-544	96	14	previously	previously	ADV
admet-544	96	15	.	.	PUNCT
admet-544	97	1	using	use	VERB
admet-544	97	2	the	the	DET
admet-544	97	3	slope	slope	NOUN
admet-544	97	4	and	and	CCONJ
admet-544	97	5	intercept	intercept	NOUN
admet-544	97	6	values	value	NOUN
admet-544	97	7	from	from	ADP
admet-544	97	8	the	the	DET
admet-544	97	9	calibration	calibration	NOUN
admet-544	97	10	line	line	NOUN
admet-544	97	11	the	the	DET
admet-544	97	12	logarithmic	logarithmic	ADJ
admet-544	97	13	retention	retention	NOUN
admet-544	97	14	times	time	NOUN
admet-544	97	15	were	be	AUX
admet-544	97	16	converted	convert	VERB
admet-544	97	17	to	to	PART
admet-544	97	18	log	log	VERB
admet-544	97	19	k	k	PROPN
admet-544	97	20	values	value	NOUN
admet-544	97	21	that	that	PRON
admet-544	97	22	can	can	AUX
admet-544	97	23	be	be	AUX
admet-544	97	24	converted	convert	VERB
admet-544	97	25	to	to	ADP
admet-544	97	26	%	%	NOUN
admet-544	97	27	binding	bind	VERB
admet-544	97	28	values	value	NOUN
admet-544	97	29	(	(	PUNCT
admet-544	97	30	%	%	INTJ
admet-544	97	31	hsa	hsa	NOUN
admet-544	97	32	and	and	CCONJ
admet-544	97	33	%	%	INTJ
admet-544	97	34	agp	agp	NOUN
admet-544	97	35	)	)	PUNCT
admet-544	97	36	using	use	VERB
admet-544	97	37	equation	equation	NOUN
admet-544	97	38	3	3	NUM
admet-544	97	39	[	[	X
admet-544	97	40	34	34	NUM
admet-544	97	41	]	]	PUNCT
admet-544	97	42	.	.	PUNCT
admet-544	98	1	klara	klara	PROPN
admet-544	98	2	valko	valko	PROPN
admet-544	98	3	et	et	PROPN
admet-544	98	4	al	al	PROPN
admet-544	98	5	.	.	PROPN
admet-544	98	6	admet	admet	PROPN
admet-544	98	7	&	&	CCONJ
admet-544	98	8	dmpk	dmpk	PROPN
admet-544	98	9	6(2	6(2	NUM
admet-544	98	10	)	)	PUNCT
admet-544	98	11	(	(	PUNCT
admet-544	98	12	2018	2018	NUM
admet-544	98	13	)	)	PUNCT
admet-544	98	14	162	162	NUM
admet-544	98	15	-	-	SYM
admet-544	98	16	175	175	NUM
admet-544	98	17	166	166	NUM
admet-544	98	18	log	log	NOUN
admet-544	98	19	log	log	NOUN
admet-544	98	20	101	101	NUM
admet-544	98	21	10	10	NUM
admet-544	98	22	%	%	NOUN
admet-544	98	23	bound	bind	VERB
admet-544	98	24	1	1	NUM
admet-544	98	25	10	10	NUM
admet-544	98	26	k	k	NOUN
admet-544	98	27	k	k	PROPN
admet-544	99	1			PROPN
admet-544	99	2			PROPN
admet-544	99	3			PUNCT
admet-544	99	4	(	(	PUNCT
admet-544	99	5	3	3	X
admet-544	99	6	)	)	PUNCT
admet-544	99	7	compounds	compound	NOUN
admet-544	99	8	studied	study	VERB
admet-544	99	9	the	the	DET
admet-544	99	10	linear	linear	ADJ
admet-544	99	11	peptides	peptide	NOUN
admet-544	99	12	were	be	AUX
admet-544	99	13	obtained	obtain	VERB
admet-544	99	14	from	from	ADP
admet-544	99	15	genervon	genervon	PROPN
admet-544	99	16	biopharmaceuticals	biopharmaceutical	NOUN
admet-544	99	17	llc	llc	PROPN
admet-544	99	18	(	(	PUNCT
admet-544	99	19	california	california	PROPN
admet-544	99	20	,	,	PUNCT
admet-544	99	21	usa	usa	PROPN
admet-544	99	22	)	)	PUNCT
admet-544	99	23	.	.	PUNCT
admet-544	100	1	these	these	DET
admet-544	100	2	peptides	peptide	NOUN
admet-544	100	3	were	be	AUX
admet-544	100	4	discovered	discover	VERB
admet-544	100	5	as	as	ADP
admet-544	100	6	endogenous	endogenous	ADJ
admet-544	100	7	motor	motor	NOUN
admet-544	100	8	neuron	neuron	NOUN
admet-544	100	9	trophic	trophic	ADJ
admet-544	100	10	peptides	peptide	NOUN
admet-544	100	11	that	that	PRON
admet-544	100	12	have	have	VERB
admet-544	100	13	a	a	DET
admet-544	100	14	great	great	ADJ
admet-544	100	15	potential	potential	NOUN
admet-544	100	16	to	to	PART
admet-544	100	17	cure	cure	VERB
admet-544	100	18	amyotrophic	amyotrophic	ADJ
admet-544	100	19	lateral	lateral	ADJ
admet-544	100	20	sclerosis	sclerosis	NOUN
admet-544	100	21	(	(	PUNCT
admet-544	100	22	als	als	NOUN
admet-544	100	23	)	)	PUNCT
admet-544	100	24	.	.	PUNCT
admet-544	101	1	the	the	DET
admet-544	101	2	peptide	peptide	NOUN
admet-544	101	3	with	with	ADP
admet-544	101	4	6	6	NUM
admet-544	101	5	amino	amino	ADJ
admet-544	101	6	acids	acid	NOUN
admet-544	101	7	(	(	PUNCT
admet-544	101	8	gm6	gm6	NOUN
admet-544	101	9	)	)	PUNCT
admet-544	101	10	has	have	AUX
admet-544	101	11	already	already	ADV
admet-544	101	12	been	be	AUX
admet-544	101	13	tested	test	VERB
admet-544	101	14	in	in	ADP
admet-544	101	15	animal	animal	NOUN
admet-544	101	16	models	model	NOUN
admet-544	101	17	of	of	ADP
admet-544	101	18	als	al	NOUN
admet-544	101	19	and	and	CCONJ
admet-544	101	20	in	in	ADP
admet-544	101	21	phase	phase	NOUN
admet-544	101	22	ii	ii	PROPN
admet-544	101	23	human	human	ADJ
admet-544	101	24	clinical	clinical	ADJ
admet-544	101	25	trials	trial	NOUN
admet-544	101	26	.	.	PUNCT
admet-544	102	1	the	the	DET
admet-544	102	2	analogues	analogue	NOUN
admet-544	102	3	are	be	AUX
admet-544	102	4	marked	mark	VERB
admet-544	102	5	as	as	ADP
admet-544	102	6	linear	linear	ADJ
admet-544	102	7	peptides	peptide	NOUN
admet-544	102	8	(	(	PUNCT
admet-544	102	9	lp	lp	NOUN
admet-544	102	10	)	)	PUNCT
admet-544	102	11	with	with	ADP
admet-544	102	12	a	a	DET
admet-544	102	13	serial	serial	ADJ
admet-544	102	14	number	number	NOUN
admet-544	102	15	.	.	PUNCT
admet-544	103	1	the	the	DET
admet-544	103	2	bicyclic	bicyclic	ADJ
admet-544	103	3	peptides	peptide	NOUN
admet-544	103	4	were	be	AUX
admet-544	103	5	obtained	obtain	VERB
admet-544	103	6	from	from	ADP
admet-544	103	7	bicycle	bicycle	PROPN
admet-544	103	8	tx	tx	PROPN
admet-544	103	9	,	,	PUNCT
admet-544	103	10	cambridge	cambridge	PROPN
admet-544	103	11	,	,	PUNCT
admet-544	103	12	uk	uk	PROPN
admet-544	103	13	and	and	CCONJ
admet-544	103	14	are	be	AUX
admet-544	103	15	marked	mark	VERB
admet-544	103	16	as	as	ADP
admet-544	103	17	bcp	bcp	NOUN
admet-544	103	18	with	with	ADP
admet-544	103	19	a	a	DET
admet-544	103	20	serial	serial	ADJ
admet-544	103	21	number	number	NOUN
admet-544	103	22	.	.	PUNCT
admet-544	104	1	these	these	PRON
admet-544	104	2	are	be	AUX
admet-544	104	3	in	in	ADP
admet-544	104	4	the	the	DET
admet-544	104	5	early	early	ADJ
admet-544	104	6	stages	stage	NOUN
admet-544	104	7	of	of	ADP
admet-544	104	8	the	the	DET
admet-544	104	9	drug	drug	NOUN
admet-544	104	10	discovery	discovery	NOUN
admet-544	104	11	process	process	NOUN
admet-544	104	12	.	.	PUNCT
admet-544	105	1	data	datum	NOUN
admet-544	105	2	analysis	analysis	NOUN
admet-544	105	3	the	the	DET
admet-544	105	4	calculation	calculation	NOUN
admet-544	105	5	of	of	ADP
admet-544	105	6	the	the	DET
admet-544	105	7	biomimetic	biomimetic	ADJ
admet-544	105	8	binding	bind	VERB
admet-544	105	9	properties	property	NOUN
admet-544	105	10	from	from	ADP
admet-544	105	11	the	the	DET
admet-544	105	12	measured	measure	VERB
admet-544	105	13	retention	retention	NOUN
admet-544	105	14	time	time	NOUN
admet-544	105	15	values	value	NOUN
admet-544	105	16	and	and	CCONJ
admet-544	105	17	estimating	estimate	VERB
admet-544	105	18	the	the	DET
admet-544	105	19	in	in	ADP
admet-544	105	20	vivo	vivo	ADJ
admet-544	105	21	distribution	distribution	NOUN
admet-544	105	22	characteristics	characteristic	NOUN
admet-544	105	23	and	and	CCONJ
admet-544	105	24	cellular	cellular	ADJ
admet-544	105	25	concentration	concentration	NOUN
admet-544	105	26	[	[	X
admet-544	105	27	35	35	NUM
admet-544	105	28	]	]	PUNCT
admet-544	105	29	are	be	AUX
admet-544	105	30	based	base	VERB
admet-544	105	31	on	on	ADP
admet-544	105	32	the	the	DET
admet-544	105	33	published	publish	VERB
admet-544	105	34	models	model	NOUN
admet-544	105	35	[	[	X
admet-544	105	36	36	36	NUM
admet-544	105	37	]	]	PUNCT
admet-544	105	38	and	and	CCONJ
admet-544	105	39	have	have	AUX
admet-544	105	40	been	be	AUX
admet-544	105	41	carried	carry	VERB
admet-544	105	42	out	out	ADP
admet-544	105	43	using	use	VERB
admet-544	105	44	the	the	DET
admet-544	105	45	bio	bio	ADJ
admet-544	105	46	-	-	ADJ
admet-544	105	47	mimetic	mimetic	ADJ
admet-544	105	48	chromatography	chromatography	NOUN
admet-544	105	49	ltd	ltd	PROPN
admet-544	105	50	propriety	propriety	NOUN
admet-544	105	51	excel	excel	VERB
admet-544	105	52	macros	macro	NOUN
admet-544	105	53	.	.	PUNCT
admet-544	106	1	the	the	DET
admet-544	106	2	statistical	statistical	ADJ
admet-544	106	3	analysis	analysis	NOUN
admet-544	106	4	was	be	AUX
admet-544	106	5	carried	carry	VERB
admet-544	106	6	out	out	ADP
admet-544	106	7	using	use	VERB
admet-544	106	8	jmp	jmp	PROPN
admet-544	106	9	13	13	NUM
admet-544	106	10	(	(	PUNCT
admet-544	106	11	sas	sas	PROPN
admet-544	106	12	institute	institute	PROPN
admet-544	106	13	,	,	PUNCT
admet-544	106	14	usa	usa	PROPN
admet-544	106	15	)	)	PUNCT
admet-544	106	16	and	and	CCONJ
admet-544	106	17	the	the	DET
admet-544	106	18	visualizations	visualization	NOUN
admet-544	106	19	have	have	AUX
admet-544	106	20	been	be	AUX
admet-544	106	21	made	make	VERB
admet-544	106	22	by	by	ADP
admet-544	106	23	stardrop	stardrop	NOUN
admet-544	106	24	software	software	NOUN
admet-544	106	25	(	(	PUNCT
admet-544	106	26	optibrium	optibrium	PROPN
admet-544	106	27	ltd	ltd	PROPN
admet-544	106	28	.	.	PROPN
admet-544	106	29	cambridge	cambridge	PROPN
admet-544	106	30	,	,	PUNCT
admet-544	106	31	uk	uk	PROPN
admet-544	106	32	)	)	PUNCT
admet-544	106	33	.	.	PUNCT
admet-544	107	1	results	result	NOUN
admet-544	107	2	and	and	CCONJ
admet-544	107	3	discussion	discussion	NOUN
admet-544	107	4	the	the	DET
admet-544	107	5	chromatographic	chromatographic	ADJ
admet-544	107	6	peaks	peak	NOUN
admet-544	107	7	were	be	AUX
admet-544	107	8	symmetrical	symmetrical	ADJ
admet-544	107	9	and	and	CCONJ
admet-544	107	10	narrow	narrow	ADJ
admet-544	107	11	on	on	ADP
admet-544	107	12	the	the	DET
admet-544	107	13	c18	c18	NOUN
admet-544	107	14	and	and	CCONJ
admet-544	107	15	iam	iam	PROPN
admet-544	107	16	stationary	stationary	ADJ
admet-544	107	17	phases	phase	NOUN
admet-544	107	18	.	.	PUNCT
admet-544	108	1	a	a	DET
admet-544	108	2	few	few	ADJ
admet-544	108	3	examples	example	NOUN
admet-544	108	4	are	be	AUX
admet-544	108	5	shown	show	VERB
admet-544	108	6	in	in	ADP
admet-544	108	7	figure	figure	NOUN
admet-544	108	8	1	1	NUM
admet-544	108	9	.	.	PUNCT
admet-544	109	1	however	however	ADV
admet-544	109	2	,	,	PUNCT
admet-544	109	3	larger	large	ADJ
admet-544	109	4	peptides	peptide	NOUN
admet-544	109	5	(	(	PUNCT
admet-544	109	6	containing	contain	VERB
admet-544	109	7	more	more	ADJ
admet-544	109	8	than	than	ADP
admet-544	109	9	10	10	NUM
admet-544	109	10	amino	amino	ADJ
admet-544	109	11	acids	acid	NOUN
admet-544	109	12	)	)	PUNCT
admet-544	109	13	showed	show	VERB
admet-544	109	14	wide	wide	ADJ
admet-544	109	15	peaks	peak	NOUN
admet-544	109	16	on	on	ADP
admet-544	109	17	the	the	DET
admet-544	109	18	hsa	hsa	PROPN
admet-544	109	19	column	column	NOUN
admet-544	109	20	with	with	ADP
admet-544	109	21	a	a	DET
admet-544	109	22	narrow	narrow	ADJ
admet-544	109	23	peak	peak	NOUN
admet-544	109	24	at	at	ADP
admet-544	109	25	the	the	DET
admet-544	109	26	dead	dead	ADJ
admet-544	109	27	time	time	NOUN
admet-544	109	28	showing	show	VERB
admet-544	109	29	a	a	DET
admet-544	109	30	size	size	NOUN
admet-544	109	31	exclusion	exclusion	NOUN
admet-544	109	32	effect	effect	NOUN
admet-544	109	33	(	(	PUNCT
admet-544	109	34	figure	figure	NOUN
admet-544	109	35	2	2	NUM
admet-544	109	36	)	)	PUNCT
admet-544	109	37	.	.	PUNCT
admet-544	110	1	size	size	NOUN
admet-544	110	2	exclusion	exclusion	NOUN
admet-544	110	3	occurs	occur	VERB
admet-544	110	4	when	when	SCONJ
admet-544	110	5	large	large	ADJ
admet-544	110	6	molecules	molecule	NOUN
admet-544	110	7	can	can	AUX
admet-544	110	8	not	not	PART
admet-544	110	9	get	get	VERB
admet-544	110	10	into	into	ADP
admet-544	110	11	the	the	DET
admet-544	110	12	pores	pore	NOUN
admet-544	110	13	of	of	ADP
admet-544	110	14	the	the	DET
admet-544	110	15	stationary	stationary	ADJ
admet-544	110	16	phases	phase	NOUN
admet-544	110	17	and	and	CCONJ
admet-544	110	18	elute	elute	VERB
admet-544	110	19	with	with	ADP
admet-544	110	20	short	short	ADJ
admet-544	110	21	retention	retention	NOUN
admet-544	110	22	times	time	NOUN
admet-544	110	23	.	.	PUNCT
admet-544	111	1	it	it	PRON
admet-544	111	2	is	be	AUX
admet-544	111	3	worth	worth	ADJ
admet-544	111	4	mentioning	mention	VERB
admet-544	111	5	that	that	SCONJ
admet-544	111	6	the	the	DET
admet-544	111	7	gemini	gemini	PROPN
admet-544	111	8	nt	nt	PROPN
admet-544	111	9	c-18	c-18	PROPN
admet-544	111	10	column	column	NOUN
admet-544	111	11	particle	particle	NOUN
admet-544	111	12	pore	pore	ADJ
admet-544	111	13	size	size	NOUN
admet-544	111	14	is	be	AUX
admet-544	111	15	110	110	NUM
admet-544	111	16	å	å	PROPN
admet-544	111	17	and	and	CCONJ
admet-544	111	18	the	the	DET
admet-544	111	19	iam	iam	PROPN
admet-544	111	20	pc.dd2	pc.dd2	PROPN
admet-544	111	21	column	column	NOUN
admet-544	111	22	pore	pore	ADJ
admet-544	111	23	size	size	NOUN
admet-544	111	24	is	be	AUX
admet-544	111	25	300	300	NUM
admet-544	111	26	å	å	PROPN
admet-544	111	27	and	and	CCONJ
admet-544	111	28	that	that	PRON
admet-544	111	29	would	would	AUX
admet-544	111	30	not	not	PART
admet-544	111	31	produce	produce	VERB
admet-544	111	32	a	a	DET
admet-544	111	33	size	size	NOUN
admet-544	111	34	exclusion	exclusion	NOUN
admet-544	111	35	effect	effect	NOUN
admet-544	111	36	for	for	ADP
admet-544	111	37	peptides	peptide	NOUN
admet-544	111	38	below	below	ADP
admet-544	111	39	3000	3000	NUM
admet-544	111	40	da	da	NOUN
admet-544	111	41	molecular	molecular	ADJ
admet-544	111	42	weight	weight	NOUN
admet-544	111	43	.	.	PUNCT
admet-544	112	1	the	the	DET
admet-544	112	2	good	good	ADJ
admet-544	112	3	peak	peak	NOUN
admet-544	112	4	shape	shape	NOUN
admet-544	112	5	also	also	ADV
admet-544	112	6	suggests	suggest	VERB
admet-544	112	7	single	single	ADJ
admet-544	112	8	interaction	interaction	NOUN
admet-544	112	9	points	point	NOUN
admet-544	112	10	between	between	ADP
admet-544	112	11	the	the	DET
admet-544	112	12	peptide	peptide	NOUN
admet-544	112	13	and	and	CCONJ
admet-544	112	14	the	the	DET
admet-544	112	15	stationary	stationary	ADJ
admet-544	112	16	phase	phase	NOUN
admet-544	112	17	on	on	ADP
admet-544	112	18	the	the	DET
admet-544	112	19	c-18	c-18	PROPN
admet-544	112	20	and	and	CCONJ
admet-544	112	21	on	on	ADP
admet-544	112	22	the	the	DET
admet-544	112	23	iam	iam	PROPN
admet-544	112	24	stationary	stationary	ADJ
admet-544	112	25	phases	phase	NOUN
admet-544	112	26	.	.	PUNCT
admet-544	113	1	the	the	DET
admet-544	113	2	broad	broad	ADJ
admet-544	113	3	peak	peak	NOUN
admet-544	113	4	observed	observe	VERB
admet-544	113	5	for	for	ADP
admet-544	113	6	lp10	lp10	PROPN
admet-544	113	7	indicates	indicate	VERB
admet-544	113	8	multiple	multiple	ADJ
admet-544	113	9	binding	bind	VERB
admet-544	113	10	interactions	interaction	NOUN
admet-544	113	11	with	with	ADP
admet-544	113	12	a	a	DET
admet-544	113	13	slow	slow	ADJ
admet-544	113	14	kinetics	kinetic	NOUN
admet-544	113	15	between	between	ADP
admet-544	113	16	the	the	DET
admet-544	113	17	peptide	peptide	NOUN
admet-544	113	18	and	and	CCONJ
admet-544	113	19	the	the	DET
admet-544	113	20	protein	protein	NOUN
admet-544	113	21	.	.	PUNCT
admet-544	114	1	the	the	DET
admet-544	114	2	bicyclic	bicyclic	NOUN
admet-544	114	3	peptides	peptide	NOUN
admet-544	114	4	also	also	ADV
admet-544	114	5	showed	show	VERB
admet-544	114	6	broad	broad	ADJ
admet-544	114	7	peaks	peak	NOUN
admet-544	114	8	both	both	PRON
admet-544	114	9	for	for	ADP
admet-544	114	10	compounds	compound	NOUN
admet-544	114	11	with	with	ADP
admet-544	114	12	shorter	short	ADJ
admet-544	114	13	and	and	CCONJ
admet-544	114	14	longer	long	ADJ
admet-544	114	15	retention	retention	NOUN
admet-544	114	16	times	time	NOUN
admet-544	114	17	.	.	PUNCT
admet-544	115	1	the	the	DET
admet-544	115	2	peak	peak	NOUN
admet-544	115	3	shape	shape	NOUN
admet-544	115	4	of	of	ADP
admet-544	115	5	the	the	DET
admet-544	115	6	linear	linear	ADJ
admet-544	115	7	peptides	peptide	NOUN
admet-544	115	8	was	be	AUX
admet-544	115	9	narrow	narrow	ADJ
admet-544	115	10	and	and	CCONJ
admet-544	115	11	symmetrical	symmetrical	ADJ
admet-544	115	12	up	up	ADP
admet-544	115	13	to	to	PART
admet-544	115	14	21	21	NUM
admet-544	115	15	amino	amino	NOUN
admet-544	115	16	acids	acid	NOUN
admet-544	115	17	.	.	PUNCT
admet-544	116	1	table	table	NOUN
admet-544	116	2	2	2	NUM
admet-544	116	3	shows	show	VERB
admet-544	116	4	the	the	DET
admet-544	116	5	measured	measured	ADJ
admet-544	116	6	data	datum	NOUN
admet-544	116	7	for	for	ADP
admet-544	116	8	10	10	NUM
admet-544	116	9	linear	linear	ADJ
admet-544	116	10	and	and	CCONJ
admet-544	116	11	10	10	NUM
admet-544	116	12	bicyclic	bicyclic	ADJ
admet-544	116	13	peptides	peptide	NOUN
admet-544	116	14	.	.	PUNCT
admet-544	117	1	the	the	DET
admet-544	117	2	lipophilicity	lipophilicity	NOUN
admet-544	117	3	difference	difference	NOUN
admet-544	117	4	at	at	ADP
admet-544	117	5	acidic	acidic	ADJ
admet-544	117	6	,	,	PUNCT
admet-544	117	7	neutral	neutral	ADJ
admet-544	117	8	and	and	CCONJ
admet-544	117	9	basic	basic	ADJ
admet-544	117	10	phs	phs	NOUN
admet-544	117	11	reveal	reveal	VERB
admet-544	117	12	the	the	DET
admet-544	117	13	overall	overall	ADJ
admet-544	117	14	charges	charge	NOUN
admet-544	117	15	on	on	ADP
admet-544	117	16	the	the	DET
admet-544	117	17	molecules	molecule	NOUN
admet-544	117	18	at	at	ADP
admet-544	117	19	physiological	physiological	ADJ
admet-544	117	20	phs	phs	NOUN
admet-544	117	21	and	and	CCONJ
admet-544	117	22	whether	whether	SCONJ
admet-544	117	23	the	the	DET
admet-544	117	24	peptides	peptide	NOUN
admet-544	117	25	are	be	AUX
admet-544	117	26	more	more	ADV
admet-544	117	27	positively	positively	ADV
admet-544	117	28	or	or	CCONJ
admet-544	117	29	negatively	negatively	ADV
admet-544	117	30	charged	charge	VERB
admet-544	117	31	.	.	PUNCT
admet-544	118	1	it	it	PRON
admet-544	118	2	has	have	AUX
admet-544	118	3	been	be	AUX
admet-544	118	4	found	find	VERB
admet-544	118	5	that	that	SCONJ
admet-544	118	6	the	the	DET
admet-544	118	7	ph	ph	ADJ
admet-544	118	8	dependence	dependence	NOUN
admet-544	118	9	of	of	ADP
admet-544	118	10	the	the	DET
admet-544	118	11	gradient	gradient	ADJ
admet-544	118	12	retention	retention	NOUN
admet-544	118	13	times	time	NOUN
admet-544	118	14	shows	show	VERB
admet-544	118	15	a	a	DET
admet-544	118	16	similar	similar	ADJ
admet-544	118	17	profile	profile	NOUN
admet-544	118	18	to	to	ADP
admet-544	118	19	the	the	DET
admet-544	118	20	ph	ph	ADJ
admet-544	118	21	dependence	dependence	NOUN
admet-544	118	22	of	of	ADP
admet-544	118	23	the	the	DET
admet-544	118	24	octanol	octanol	NOUN
admet-544	118	25	/	/	SYM
admet-544	118	26	water	water	NOUN
admet-544	118	27	distribution	distribution	NOUN
admet-544	118	28	coefficients	coefficient	NOUN
admet-544	118	29	(	(	PUNCT
admet-544	118	30	log	log	NOUN
admet-544	118	31	d	d	NOUN
admet-544	118	32	)	)	PUNCT
admet-544	119	1	[	[	X
admet-544	119	2	37	37	NUM
admet-544	119	3	]	]	PUNCT
admet-544	119	4	.	.	PUNCT
admet-544	120	1	if	if	SCONJ
admet-544	120	2	the	the	DET
admet-544	120	3	lipophilicity	lipophilicity	NOUN
admet-544	120	4	increased	increase	VERB
admet-544	120	5	at	at	ADP
admet-544	120	6	a	a	DET
admet-544	120	7	basic	basic	ADJ
admet-544	120	8	ph	ph	NOUN
admet-544	120	9	relative	relative	NOUN
admet-544	120	10	to	to	ADP
admet-544	120	11	the	the	DET
admet-544	120	12	neutral	neutral	ADJ
admet-544	120	13	ph	ph	ADJ
admet-544	120	14	lipophilicity	lipophilicity	NOUN
admet-544	120	15	,	,	PUNCT
admet-544	120	16	it	it	PRON
admet-544	120	17	would	would	AUX
admet-544	120	18	suggest	suggest	VERB
admet-544	120	19	that	that	SCONJ
admet-544	120	20	the	the	DET
admet-544	120	21	peptide	peptide	NOUN
admet-544	120	22	has	have	VERB
admet-544	120	23	more	more	ADV
admet-544	120	24	positive	positive	ADJ
admet-544	120	25	than	than	ADP
admet-544	120	26	negative	negative	ADJ
admet-544	120	27	charge	charge	NOUN
admet-544	120	28	.	.	PUNCT
admet-544	121	1	if	if	SCONJ
admet-544	121	2	the	the	DET
admet-544	121	3	lipophilicity	lipophilicity	NOUN
admet-544	121	4	increases	increase	VERB
admet-544	121	5	at	at	ADP
admet-544	121	6	an	an	DET
admet-544	121	7	acidic	acidic	ADJ
admet-544	121	8	ph	ph	NOUN
admet-544	121	9	,	,	PUNCT
admet-544	121	10	the	the	DET
admet-544	121	11	peptide	peptide	NOUN
admet-544	121	12	has	have	VERB
admet-544	121	13	more	more	ADV
admet-544	121	14	negative	negative	ADJ
admet-544	121	15	charge	charge	NOUN
admet-544	121	16	.	.	PUNCT
admet-544	122	1	it	it	PRON
admet-544	122	2	can	can	AUX
admet-544	122	3	be	be	AUX
admet-544	122	4	seen	see	VERB
admet-544	122	5	that	that	SCONJ
admet-544	122	6	the	the	DET
admet-544	122	7	linear	linear	ADJ
admet-544	122	8	peptides	peptide	NOUN
admet-544	122	9	are	be	AUX
admet-544	122	10	positively	positively	ADV
admet-544	122	11	charged	charge	VERB
admet-544	122	12	at	at	ADP
admet-544	122	13	physiological	physiological	ADJ
admet-544	122	14	ph	ph	NOUN
admet-544	122	15	,	,	PUNCT
admet-544	122	16	while	while	SCONJ
admet-544	122	17	bcp1	bcp1	PROPN
admet-544	122	18	,	,	PUNCT
admet-544	122	19	bcp2	bcp2	NOUN
admet-544	122	20	and	and	CCONJ
admet-544	122	21	bcp10	bcp10	PROPN
admet-544	122	22	have	have	VERB
admet-544	122	23	more	more	ADV
admet-544	122	24	negative	negative	ADJ
admet-544	122	25	charge	charge	NOUN
admet-544	122	26	at	at	ADP
admet-544	122	27	physiological	physiological	ADJ
admet-544	122	28	phs	ph	NOUN
admet-544	122	29	.	.	PUNCT
admet-544	123	1	when	when	SCONJ
admet-544	123	2	plotting	plot	VERB
admet-544	123	3	the	the	DET
admet-544	123	4	chi	chi	NOUN
admet-544	123	5	log	log	NOUN
admet-544	123	6	d	d	NOUN
admet-544	123	7	at	at	ADP
admet-544	123	8	ph	ph	NOUN
admet-544	123	9	7.4	7.4	NUM
admet-544	123	10	as	as	ADP
admet-544	123	11	a	a	DET
admet-544	123	12	function	function	NOUN
admet-544	123	13	of	of	ADP
admet-544	123	14	the	the	DET
admet-544	123	15	molecular	molecular	ADJ
admet-544	123	16	weight	weight	NOUN
admet-544	123	17	,	,	PUNCT
admet-544	123	18	we	we	PRON
admet-544	123	19	can	can	AUX
admet-544	123	20	see	see	VERB
admet-544	123	21	some	some	DET
admet-544	123	22	trends	trend	NOUN
admet-544	123	23	for	for	ADP
admet-544	123	24	the	the	DET
admet-544	123	25	linear	linear	ADJ
admet-544	123	26	peptides	peptide	NOUN
admet-544	123	27	as	as	SCONJ
admet-544	123	28	shown	show	VERB
admet-544	123	29	in	in	ADP
admet-544	123	30	figure	figure	NOUN
admet-544	123	31	3	3	NUM
admet-544	123	32	.	.	PUNCT
admet-544	123	33	admet	admet	PROPN
admet-544	123	34	&	&	CCONJ
admet-544	123	35	dmpk	dmpk	PROPN
admet-544	123	36	6(2	6(2	NUM
admet-544	123	37	)	)	PUNCT
admet-544	123	38	(	(	PUNCT
admet-544	123	39	2018	2018	NUM
admet-544	123	40	)	)	PUNCT
admet-544	123	41	162	162	NUM
admet-544	123	42	-	-	SYM
admet-544	123	43	175	175	NUM
admet-544	123	44	biomimetic	biomimetic	ADJ
admet-544	123	45	hplc	hplc	NOUN
admet-544	123	46	in	in	ADP
admet-544	123	47	the	the	DET
admet-544	123	48	estimation	estimation	NOUN
admet-544	123	49	of	of	ADP
admet-544	123	50	physchem	physchem	NOUN
admet-544	123	51	properties	property	NOUN
admet-544	123	52	of	of	ADP
admet-544	123	53	peptides	peptide	NOUN
admet-544	123	54	doi	doi	NOUN
admet-544	123	55	:	:	PUNCT
admet-544	123	56	10.5599	10.5599	NUM
admet-544	123	57	/	/	SYM
admet-544	123	58	admet.544	admet.544	PROPN
admet-544	123	59	167	167	NUM
admet-544	123	60	table	table	NOUN
admet-544	123	61	2	2	NUM
admet-544	123	62	.	.	PUNCT
admet-544	124	1	the	the	DET
admet-544	124	2	measured	measured	ADJ
admet-544	124	3	protein	protein	NOUN
admet-544	124	4	binding	bind	VERB
admet-544	124	5	(	(	PUNCT
admet-544	124	6	%	%	INTJ
admet-544	124	7	hsa	hsa	PROPN
admet-544	124	8	,	,	PUNCT
admet-544	124	9	log	log	VERB
admet-544	124	10	k	k	PROPN
admet-544	124	11	hsa	hsa	PROPN
admet-544	124	12	,	,	PUNCT
admet-544	124	13	%	%	INTJ
admet-544	124	14	agp	agp	NOUN
admet-544	124	15	,	,	PUNCT
admet-544	124	16	log	log	VERB
admet-544	124	17	k	k	PROPN
admet-544	124	18	agp	agp	PROPN
admet-544	124	19	)	)	PUNCT
admet-544	124	20	,	,	PUNCT
admet-544	124	21	phospholipid	phospholipid	NOUN
admet-544	124	22	binding	bind	VERB
admet-544	124	23	(	(	PUNCT
admet-544	124	24	chi	chi	PROPN
admet-544	124	25	iam	iam	PROPN
admet-544	124	26	,	,	PUNCT
admet-544	124	27	log	log	VERB
admet-544	124	28	k	k	PROPN
admet-544	124	29	iam	iam	PROPN
admet-544	124	30	)	)	PUNCT
admet-544	124	31	and	and	CCONJ
admet-544	124	32	lipophilicity	lipophilicity	NOUN
admet-544	124	33	at	at	ADP
admet-544	124	34	three	three	NUM
admet-544	124	35	phs	phs	NOUN
admet-544	124	36	(	(	PUNCT
admet-544	124	37	chi	chi	NOUN
admet-544	124	38	log	log	VERB
admet-544	124	39	d	d	PROPN
admet-544	124	40	2.6	2.6	NUM
admet-544	124	41	,	,	PUNCT
admet-544	124	42	chi	chi	NOUN
admet-544	124	43	log	log	NOUN
admet-544	124	44	d	d	PROPN
admet-544	124	45	7.4	7.4	NUM
admet-544	124	46	,	,	PUNCT
admet-544	124	47	chi	chi	NOUN
admet-544	124	48	log	log	VERB
admet-544	124	49	d	d	PROPN
admet-544	124	50	10.5	10.5	NUM
admet-544	124	51	)	)	PUNCT
admet-544	124	52	and	and	CCONJ
admet-544	124	53	phospholipid	phospholipid	NOUN
admet-544	124	54	binding	bind	VERB
admet-544	124	55	of	of	ADP
admet-544	124	56	the	the	DET
admet-544	124	57	investigated	investigate	VERB
admet-544	124	58	linear	linear	NOUN
admet-544	124	59	(	(	PUNCT
admet-544	124	60	lp	lp	NOUN
admet-544	124	61	)	)	PUNCT
admet-544	124	62	and	and	CCONJ
admet-544	124	63	bicyclic	bicyclic	NOUN
admet-544	124	64	peptides	peptide	NOUN
admet-544	124	65	(	(	PUNCT
admet-544	124	66	bcp	bcp	PROPN
admet-544	124	67	)	)	PUNCT
admet-544	124	68	.	.	PUNCT
admet-544	125	1	the	the	DET
admet-544	125	2	data	datum	NOUN
admet-544	125	3	of	of	ADP
admet-544	125	4	the	the	DET
admet-544	125	5	known	know	VERB
admet-544	125	6	macrocyclic	macrocyclic	NOUN
admet-544	125	7	drug	drug	NOUN
admet-544	125	8	,	,	PUNCT
admet-544	125	9	cyclosporine	cyclosporine	PROPN
admet-544	125	10	is	be	AUX
admet-544	125	11	marked	mark	VERB
admet-544	125	12	as	as	ADP
admet-544	125	13	cp	cp	PROPN
admet-544	125	14	.	.	PROPN
admet-544	125	15	peptide	peptide	NOUN
admet-544	125	16	%	%	NOUN
admet-544	125	17	bound	bind	VERB
admet-544	125	18	hsa	hsa	PROPN
admet-544	125	19	log	log	VERB
admet-544	125	20	k	k	PROPN
admet-544	125	21	hsa	hsa	PROPN
admet-544	125	22	%	%	INTJ
admet-544	125	23	bound	bind	VERB
admet-544	125	24	agp	agp	PROPN
admet-544	125	25	log	log	NOUN
admet-544	126	1	k	k	PROPN
admet-544	126	2	agp	agp	PROPN
admet-544	126	3	chi	chi	PROPN
admet-544	126	4	iam	iam	PROPN
admet-544	126	5	log	log	VERB
admet-544	126	6	k	k	PROPN
admet-544	126	7	iam	iam	PROPN
admet-544	126	8	chi	chi	PROPN
admet-544	126	9	log	log	PROPN
admet-544	126	10	d	d	PROPN
admet-544	126	11	2.6	2.6	NUM
admet-544	126	12	chi	chi	NOUN
admet-544	126	13	log	log	NOUN
admet-544	126	14	d	d	NOUN
admet-544	126	15	7.4	7.4	NUM
admet-544	126	16	chi	chi	NOUN
admet-544	126	17	log	log	NOUN
admet-544	126	18	d	d	PROPN
admet-544	126	19	10.5	10.5	NUM
admet-544	126	20	lp1	lp1	PROPN
admet-544	126	21	7.85	7.85	NUM
admet-544	126	22	-1.07	-1.07	NUM
admet-544	126	23	3.70	3.70	NUM
admet-544	126	24	-1.42	-1.42	NUM
admet-544	126	25	5.47	5.47	NUM
admet-544	126	26	1.27	1.27	NUM
admet-544	126	27	-1.94	-1.94	NOUN
admet-544	126	28	-0.54	-0.54	NOUN
admet-544	126	29	-0.50	-0.50	PROPN
admet-544	126	30	lp2	lp2	PROPN
admet-544	126	31	13.58	13.58	NUM
admet-544	126	32	-0.81	-0.81	NUM
admet-544	126	33	6.85	6.85	NUM
admet-544	126	34	-1.14	-1.14	NUM
admet-544	126	35	15.32	15.32	NUM
admet-544	126	36	1.59	1.59	NUM
admet-544	126	37	-0.75	-0.75	NUM
admet-544	126	38	-0.26	-0.26	X
admet-544	126	39	-0.23	-0.23	PROPN
admet-544	126	40	lp3	lp3	PROPN
admet-544	126	41	13.15	13.15	NUM
admet-544	126	42	-0.82	-0.82	NUM
admet-544	126	43	6.82	6.82	NUM
admet-544	126	44	-1.14	-1.14	NUM
admet-544	126	45	17.46	17.46	NUM
admet-544	126	46	1.69	1.69	NUM
admet-544	126	47	-0.71	-0.71	NOUN
admet-544	126	48	-0.14	-0.14	PRON
admet-544	126	49	-0.11	-0.11	NUM
admet-544	126	50	lp4	lp4	NOUN
admet-544	126	51	24.87	24.87	NUM
admet-544	126	52	-0.49	-0.49	ADP
admet-544	126	53	61.24	61.24	NUM
admet-544	126	54	0.19	0.19	NUM
admet-544	126	55	43.04	43.04	NUM
admet-544	126	56	3.90	3.90	NUM
admet-544	126	57	-3.39	-3.39	NUM
admet-544	126	58	-0.14	-0.14	NUM
admet-544	126	59	0.22	0.22	NUM
admet-544	126	60	lp5	lp5	NOUN
admet-544	126	61	20.73	20.73	NUM
admet-544	126	62	-0.59	-0.59	NUM
admet-544	126	63	37.97	37.97	NUM
admet-544	126	64	-0.22	-0.22	NUM
admet-544	126	65	42.25	42.25	NUM
admet-544	126	66	3.78	3.78	NUM
admet-544	126	67	-3.37	-3.37	PROPN
admet-544	126	68	-0.17	-0.17	PROPN
admet-544	126	69	0.19	0.19	NUM
admet-544	126	70	lp6	lp6	NOUN
admet-544	126	71	77.54	77.54	NUM
admet-544	126	72	0.52	0.52	NUM
admet-544	126	73	49.58	49.58	NUM
admet-544	126	74	-0.02	-0.02	NUM
admet-544	126	75	25.82	25.82	NUM
admet-544	126	76	2.15	2.15	NUM
admet-544	126	77	0.87	0.87	NUM
admet-544	126	78	1.01	1.01	NUM
admet-544	126	79	1.05	1.05	NUM
admet-544	126	80	lp7	lp7	NOUN
admet-544	126	81	52.66	52.66	NUM
admet-544	126	82	0.04	0.04	NUM
admet-544	126	83	69.83	69.83	NUM
admet-544	126	84	0.35	0.35	NUM
admet-544	126	85	43.29	43.29	NUM
admet-544	126	86	3.93	3.93	NUM
admet-544	126	87	-0.15	-0.15	NUM
admet-544	126	88	0.77	0.77	NUM
admet-544	126	89	1.07	1.07	NUM
admet-544	126	90	lp8	lp8	PRON
admet-544	126	91	95.75	95.75	NUM
admet-544	126	92	1.26	1.26	NUM
admet-544	126	93	74.92	74.92	NUM
admet-544	126	94	0.46	0.46	NUM
admet-544	126	95	37.47	37.47	NUM
admet-544	126	96	3.17	3.17	NUM
admet-544	126	97	0.18	0.18	NUM
admet-544	126	98	0.83	0.83	NUM
admet-544	126	99	0.82	0.82	NUM
admet-544	126	100	lp9	lp9	PROPN
admet-544	126	101	98.97	98.97	NUM
admet-544	126	102	1.69	1.69	NUM
admet-544	126	103	89.84	89.84	NUM
admet-544	126	104	0.91	0.91	NUM
admet-544	126	105	43.80	43.80	NUM
admet-544	126	106	4.01	4.01	NUM
admet-544	126	107	1.18	1.18	NUM
admet-544	126	108	1.59	1.59	NUM
admet-544	126	109	0.61	0.61	NUM
admet-544	127	1	lp10	lp10	PROPN
admet-544	127	2	99.07	99.07	NUM
admet-544	127	3	1.71	1.71	NUM
admet-544	127	4	87.83	87.83	NUM
admet-544	127	5	0.82	0.82	NUM
admet-544	127	6	37.66	37.66	NUM
admet-544	127	7	3.20	3.20	NUM
admet-544	127	8	1.17	1.17	NUM
admet-544	127	9	1.60	1.60	NUM
admet-544	127	10	0.61	0.61	NUM
admet-544	127	11	bcp1	bcp1	NOUN
admet-544	127	12	71.25	71.25	NUM
admet-544	127	13	0.38	0.38	NUM
admet-544	127	14	63.54	63.54	NUM
admet-544	127	15	0.23	0.23	NUM
admet-544	127	16	16.51	16.51	NUM
admet-544	127	17	1.64	1.64	NUM
admet-544	127	18	0.98	0.98	NUM
admet-544	127	19	0.59	0.59	NUM
admet-544	127	20	0.28	0.28	NUM
admet-544	127	21	bcp2	bcp2	NOUN
admet-544	127	22	88.58	88.58	NUM
admet-544	127	23	0.85	0.85	NUM
admet-544	127	24	1.31	1.31	NUM
admet-544	127	25	-1.88	-1.88	NUM
admet-544	127	26	17.84	17.84	NUM
admet-544	127	27	1.70	1.70	NUM
admet-544	127	28	1.11	1.11	NUM
admet-544	127	29	0.75	0.75	NUM
admet-544	127	30	0.36	0.36	NUM
admet-544	127	31	bcp3	bcp3	NOUN
admet-544	127	32	19.03	19.03	NUM
admet-544	127	33	-0.63	-0.63	NUM
admet-544	127	34	1.30	1.30	NUM
admet-544	127	35	-1.89	-1.89	NUM
admet-544	127	36	16.10	16.10	NUM
admet-544	127	37	1.63	1.63	NUM
admet-544	127	38	0.24	0.24	NUM
admet-544	127	39	0.54	0.54	NUM
admet-544	127	40	0.25	0.25	NUM
admet-544	127	41	bcp4	bcp4	NOUN
admet-544	127	42	18.24	18.24	NUM
admet-544	127	43	-0.66	-0.66	NUM
admet-544	127	44	35.68	35.68	NUM
admet-544	127	45	-0.26	-0.26	NOUN
admet-544	127	46	32.48	32.48	NUM
admet-544	127	47	2.67	2.67	NUM
admet-544	127	48	0.02	0.02	NUM
admet-544	127	49	0.89	0.89	NUM
admet-544	127	50	0.38	0.38	NUM
admet-544	127	51	bcp5	bcp5	NOUN
admet-544	127	52	92.92	92.92	NUM
admet-544	127	53	1.06	1.06	NUM
admet-544	127	54	73.34	73.34	NUM
admet-544	127	55	0.42	0.42	NUM
admet-544	127	56	39.98	39.98	NUM
admet-544	127	57	3.48	3.48	NUM
admet-544	127	58	0.89	0.89	NUM
admet-544	127	59	1.79	1.79	NUM
admet-544	127	60	1.54	1.54	NUM
admet-544	127	61	bcp6	bcp6	NOUN
admet-544	127	62	26.00	26.00	NUM
admet-544	127	63	-0.46	-0.46	NUM
admet-544	127	64	2.69	2.69	NUM
admet-544	127	65	-1.56	-1.56	NUM
admet-544	127	66	21.77	21.77	NUM
admet-544	127	67	1.90	1.90	NUM
admet-544	127	68	0.75	0.75	NUM
admet-544	127	69	0.84	0.84	NUM
admet-544	127	70	0.56	0.56	NUM
admet-544	127	71	bcp7	bcp7	NOUN
admet-544	127	72	9.24	9.24	NUM
admet-544	127	73	-1.00	-1.00	NUM
admet-544	127	74	1.58	1.58	NUM
admet-544	127	75	-1.80	-1.80	NUM
admet-544	127	76	18.08	18.08	NUM
admet-544	127	77	1.71	1.71	NUM
admet-544	127	78	0.57	0.57	NUM
admet-544	127	79	0.65	0.65	NUM
admet-544	127	80	0.36	0.36	NUM
admet-544	127	81	bcp8	bcp8	PROPN
admet-544	127	82	94.41	94.41	NUM
admet-544	127	83	1.16	1.16	NUM
admet-544	127	84	83.76	83.76	NUM
admet-544	127	85	0.69	0.69	NUM
admet-544	127	86	44.90	44.90	NUM
admet-544	127	87	4.18	4.18	NUM
admet-544	127	88	1.02	1.02	NUM
admet-544	127	89	1.79	1.79	NUM
admet-544	127	90	1.70	1.70	NUM
admet-544	127	91	bcp9	bcp9	NOUN
admet-544	127	92	82.29	82.29	NUM
admet-544	127	93	0.64	0.64	NUM
admet-544	127	94	32.81	32.81	NUM
admet-544	127	95	-0.32	-0.32	VERB
admet-544	127	96	25.91	25.91	NUM
admet-544	127	97	2.15	2.15	NUM
admet-544	127	98	1.00	1.00	NUM
admet-544	127	99	1.20	1.20	NUM
admet-544	127	100	0.93	0.93	NUM
admet-544	127	101	bcp10	bcp10	NOUN
admet-544	127	102	96.28	96.28	NUM
admet-544	127	103	1.31	1.31	NUM
admet-544	127	104	49.46	49.46	NUM
admet-544	127	105	-0.02	-0.02	NUM
admet-544	127	106	21.50	21.50	NUM
admet-544	127	107	1.89	1.89	NUM
admet-544	127	108	2.27	2.27	NUM
admet-544	127	109	1.23	1.23	NUM
admet-544	127	110	0.92	0.92	NUM
admet-544	127	111	cp	cp	NUM
admet-544	127	112	91.00	91.00	NUM
admet-544	127	113	0.97	0.97	NUM
admet-544	127	114	60.9	60.9	NUM
admet-544	127	115	0.18	0.18	NUM
admet-544	127	116	51.33	51.33	NUM
admet-544	127	117	5.38	5.38	NUM
admet-544	127	118	5.31	5.31	NUM
admet-544	127	119	figure	figure	NOUN
admet-544	127	120	1	1	NUM
admet-544	127	121	.	.	NOUN
admet-544	127	122	chromatograms	chromatogram	NOUN
admet-544	127	123	of	of	ADP
admet-544	127	124	lp2	lp2	PROPN
admet-544	127	125	and	and	CCONJ
admet-544	127	126	lp8	lp8	PRON
admet-544	127	127	obtained	obtain	VERB
admet-544	127	128	on	on	ADP
admet-544	127	129	gemini	gemini	PROPN
admet-544	127	130	nx	nx	PROPN
admet-544	127	131	c-18	c-18	PROPN
admet-544	127	132	and	and	CCONJ
admet-544	127	133	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	127	134	columns	column	NOUN
admet-544	127	135	at	at	ADP
admet-544	127	136	ph	ph	PROPN
admet-544	127	137	7.4	7.4	NUM
admet-544	127	138	.	.	PUNCT
admet-544	128	1	a	a	DET
admet-544	128	2	)	)	PUNCT
admet-544	128	3	lp2	lp2	PROPN
admet-544	128	4	c-18	c-18	PROPN
admet-544	128	5	column	column	NOUN
admet-544	128	6	,	,	PUNCT
admet-544	128	7	b	b	X
admet-544	128	8	)	)	PUNCT
admet-544	128	9	lp8	lp8	X
admet-544	128	10	on	on	ADP
admet-544	128	11	c-18	c-18	PROPN
admet-544	128	12	column	column	NOUN
admet-544	128	13	,	,	PUNCT
admet-544	128	14	c	c	NOUN
admet-544	128	15	)	)	PUNCT
admet-544	128	16	lp2	lp2	PROPN
admet-544	128	17	on	on	ADP
admet-544	128	18	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	128	19	column	column	PROPN
admet-544	128	20	,	,	PUNCT
admet-544	128	21	d	d	X
admet-544	128	22	)	)	PUNCT
admet-544	128	23	lp8	lp8	NOUN
admet-544	128	24	on	on	ADP
admet-544	128	25	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	128	26	column	column	PROPN
admet-544	128	27	klara	klara	PROPN
admet-544	128	28	valko	valko	PROPN
admet-544	128	29	et	et	PROPN
admet-544	128	30	al	al	PROPN
admet-544	128	31	.	.	PROPN
admet-544	128	32	admet	admet	PROPN
admet-544	128	33	&	&	CCONJ
admet-544	128	34	dmpk	dmpk	PROPN
admet-544	128	35	6(2	6(2	NUM
admet-544	128	36	)	)	PUNCT
admet-544	128	37	(	(	PUNCT
admet-544	128	38	2018	2018	NUM
admet-544	128	39	)	)	PUNCT
admet-544	128	40	162	162	NUM
admet-544	128	41	-	-	SYM
admet-544	128	42	175	175	NUM
admet-544	128	43	168	168	NUM
admet-544	128	44	figure	figure	NOUN
admet-544	128	45	2	2	NUM
admet-544	128	46	.	.	PUNCT
admet-544	129	1	the	the	DET
admet-544	129	2	chromatogram	chromatogram	NOUN
admet-544	129	3	obtained	obtain	VERB
admet-544	129	4	on	on	ADP
admet-544	129	5	chiralpak	chiralpak	ADJ
admet-544	129	6	-	-	PUNCT
admet-544	129	7	hsa	hsa	PROPN
admet-544	129	8	column	column	NOUN
admet-544	129	9	for	for	ADP
admet-544	129	10	lp4	lp4	PROPN
admet-544	129	11	(	(	PUNCT
admet-544	129	12	a	a	NOUN
admet-544	129	13	)	)	PUNCT
admet-544	129	14	and	and	CCONJ
admet-544	129	15	lp10	lp10	PROPN
admet-544	129	16	(	(	PUNCT
admet-544	129	17	b	b	NOUN
admet-544	129	18	)	)	PUNCT
admet-544	129	19	.	.	PUNCT
admet-544	130	1	chromatographic	chromatographic	ADJ
admet-544	130	2	conditions	condition	NOUN
admet-544	130	3	as	as	SCONJ
admet-544	130	4	described	describe	VERB
admet-544	130	5	in	in	ADP
admet-544	130	6	the	the	DET
admet-544	130	7	experimental	experimental	ADJ
admet-544	130	8	section	section	NOUN
admet-544	130	9	.	.	PUNCT
admet-544	131	1	figure	figure	NOUN
admet-544	131	2	3	3	NUM
admet-544	131	3	.	.	PUNCT
admet-544	132	1	the	the	DET
admet-544	132	2	chi	chi	PROPN
admet-544	132	3	log	log	NOUN
admet-544	132	4	d7.4	d7.4	NOUN
admet-544	132	5	values	value	NOUN
admet-544	132	6	of	of	ADP
admet-544	132	7	the	the	DET
admet-544	132	8	investigated	investigate	VERB
admet-544	132	9	peptides	peptide	NOUN
admet-544	132	10	as	as	ADP
admet-544	132	11	a	a	DET
admet-544	132	12	function	function	NOUN
admet-544	132	13	of	of	ADP
admet-544	132	14	their	their	PRON
admet-544	132	15	molecular	molecular	ADJ
admet-544	132	16	weight	weight	NOUN
admet-544	132	17	.	.	PUNCT
admet-544	133	1	figure	figure	NOUN
admet-544	133	2	4	4	NUM
admet-544	133	3	.	.	PUNCT
admet-544	134	1	the	the	DET
admet-544	134	2	chi	chi	PROPN
admet-544	134	3	iam	iam	PROPN
admet-544	134	4	values	value	NOUN
admet-544	134	5	of	of	ADP
admet-544	134	6	the	the	DET
admet-544	134	7	investigated	investigate	VERB
admet-544	134	8	peptides	peptide	NOUN
admet-544	134	9	as	as	ADP
admet-544	134	10	a	a	DET
admet-544	134	11	function	function	NOUN
admet-544	134	12	of	of	ADP
admet-544	134	13	molecular	molecular	ADJ
admet-544	134	14	weight	weight	NOUN
admet-544	134	15	.	.	PUNCT
admet-544	135	1	admet	admet	PROPN
admet-544	135	2	&	&	CCONJ
admet-544	135	3	dmpk	dmpk	PROPN
admet-544	135	4	6(2	6(2	NUM
admet-544	135	5	)	)	PUNCT
admet-544	135	6	(	(	PUNCT
admet-544	135	7	2018	2018	NUM
admet-544	135	8	)	)	PUNCT
admet-544	135	9	162	162	NUM
admet-544	135	10	-	-	SYM
admet-544	135	11	175	175	NUM
admet-544	135	12	biomimetic	biomimetic	ADJ
admet-544	135	13	hplc	hplc	NOUN
admet-544	135	14	in	in	ADP
admet-544	135	15	the	the	DET
admet-544	135	16	estimation	estimation	NOUN
admet-544	135	17	of	of	ADP
admet-544	135	18	physchem	physchem	NOUN
admet-544	135	19	properties	property	NOUN
admet-544	135	20	of	of	ADP
admet-544	135	21	peptides	peptide	NOUN
admet-544	135	22	doi	doi	NOUN
admet-544	135	23	:	:	PUNCT
admet-544	135	24	10.5599	10.5599	NUM
admet-544	135	25	/	/	SYM
admet-544	135	26	admet.544	admet.544	PROPN
admet-544	135	27	169	169	NUM
admet-544	135	28	figure	figure	NOUN
admet-544	135	29	5	5	NUM
admet-544	135	30	.	.	PUNCT
admet-544	136	1	the	the	DET
admet-544	136	2	human	human	ADJ
admet-544	136	3	serum	serum	NOUN
admet-544	136	4	albumin	albumin	NOUN
admet-544	136	5	binding	bind	VERB
admet-544	136	6	(	(	PUNCT
admet-544	136	7	log	log	PROPN
admet-544	136	8	khsa	khsa	NOUN
admet-544	136	9	)	)	PUNCT
admet-544	136	10	of	of	ADP
admet-544	136	11	the	the	DET
admet-544	136	12	investigated	investigate	VERB
admet-544	136	13	peptides	peptide	NOUN
admet-544	136	14	as	as	ADP
admet-544	136	15	a	a	DET
admet-544	136	16	function	function	NOUN
admet-544	136	17	of	of	ADP
admet-544	136	18	molecular	molecular	ADJ
admet-544	136	19	weight	weight	NOUN
admet-544	136	20	.	.	PUNCT
admet-544	137	1	from	from	ADP
admet-544	137	2	lp1	lp1	PROPN
admet-544	137	3	to	to	ADP
admet-544	137	4	lp10	lp10	PROPN
admet-544	137	5	the	the	DET
admet-544	137	6	lipophilicity	lipophilicity	NOUN
admet-544	137	7	increases	increase	VERB
admet-544	137	8	with	with	ADP
admet-544	137	9	size	size	NOUN
admet-544	137	10	,	,	PUNCT
admet-544	137	11	while	while	SCONJ
admet-544	137	12	lp6	lp6	ADV
admet-544	137	13	is	be	AUX
admet-544	137	14	slightly	slightly	ADV
admet-544	137	15	more	more	ADV
admet-544	137	16	lipophilic	lipophilic	ADJ
admet-544	137	17	.	.	PUNCT
admet-544	138	1	with	with	ADP
admet-544	138	2	the	the	DET
admet-544	138	3	linear	linear	ADJ
admet-544	138	4	peptides	peptide	NOUN
admet-544	138	5	(	(	PUNCT
admet-544	138	6	lp8	lp8	X
admet-544	138	7	and	and	CCONJ
admet-544	138	8	lp10	lp10	PROPN
admet-544	138	9	)	)	PUNCT
admet-544	138	10	the	the	DET
admet-544	138	11	lipophilicity	lipophilicity	NOUN
admet-544	138	12	increased	increase	VERB
admet-544	138	13	but	but	CCONJ
admet-544	138	14	not	not	PART
admet-544	138	15	proportionally	proportionally	ADV
admet-544	138	16	with	with	ADP
admet-544	138	17	their	their	PRON
admet-544	138	18	larger	large	ADJ
admet-544	138	19	molecular	molecular	ADJ
admet-544	138	20	weight	weight	NOUN
admet-544	138	21	.	.	PUNCT
admet-544	139	1	this	this	PRON
admet-544	139	2	is	be	AUX
admet-544	139	3	in	in	ADP
admet-544	139	4	agreement	agreement	NOUN
admet-544	139	5	with	with	ADP
admet-544	139	6	the	the	DET
admet-544	139	7	finding	finding	NOUN
admet-544	139	8	that	that	SCONJ
admet-544	139	9	peptides	peptide	NOUN
admet-544	139	10	with	with	ADP
admet-544	139	11	more	more	ADJ
admet-544	139	12	than	than	ADP
admet-544	139	13	16	16	NUM
admet-544	139	14	amino	amino	ADJ
admet-544	139	15	acids	acid	NOUN
admet-544	139	16	start	start	VERB
admet-544	139	17	to	to	PART
admet-544	139	18	fold	fold	VERB
admet-544	139	19	and	and	CCONJ
admet-544	139	20	have	have	VERB
admet-544	139	21	secondary	secondary	ADJ
admet-544	139	22	structure	structure	NOUN
admet-544	139	23	that	that	PRON
admet-544	139	24	may	may	AUX
admet-544	139	25	hinder	hinder	VERB
admet-544	139	26	the	the	DET
admet-544	139	27	effect	effect	NOUN
admet-544	139	28	of	of	ADP
admet-544	139	29	certain	certain	ADJ
admet-544	139	30	amino	amino	ADJ
admet-544	139	31	acids	acid	NOUN
admet-544	139	32	on	on	ADP
admet-544	139	33	their	their	PRON
admet-544	139	34	lipophilicity	lipophilicity	NOUN
admet-544	139	35	[	[	X
admet-544	139	36	25	25	NUM
admet-544	139	37	]	]	PUNCT
admet-544	139	38	.	.	PUNCT
admet-544	140	1	similar	similar	ADJ
admet-544	140	2	trends	trend	NOUN
admet-544	140	3	have	have	AUX
admet-544	140	4	been	be	AUX
admet-544	140	5	observed	observe	VERB
admet-544	140	6	on	on	ADP
admet-544	140	7	the	the	DET
admet-544	140	8	iam.pc.dd2	iam.pc.dd2	PROPN
admet-544	140	9	stationary	stationary	ADJ
admet-544	140	10	phase	phase	NOUN
admet-544	140	11	.	.	PUNCT
admet-544	141	1	the	the	DET
admet-544	141	2	interactions	interaction	NOUN
admet-544	141	3	with	with	ADP
admet-544	141	4	the	the	DET
admet-544	141	5	phospholipid	phospholipid	NOUN
admet-544	141	6	increased	increase	VERB
admet-544	141	7	with	with	ADP
admet-544	141	8	the	the	DET
admet-544	141	9	increasing	increase	VERB
admet-544	141	10	number	number	NOUN
admet-544	141	11	of	of	ADP
admet-544	141	12	amino	amino	ADJ
admet-544	141	13	acids	acid	NOUN
admet-544	141	14	as	as	SCONJ
admet-544	141	15	shown	show	VERB
admet-544	141	16	in	in	ADP
admet-544	141	17	figure	figure	NOUN
admet-544	141	18	4	4	NUM
admet-544	141	19	.	.	PUNCT
admet-544	142	1	the	the	DET
admet-544	142	2	trend	trend	NOUN
admet-544	142	3	breaks	break	VERB
admet-544	142	4	for	for	ADP
admet-544	142	5	larger	large	ADJ
admet-544	142	6	amino	amino	NOUN
admet-544	142	7	acids	acid	NOUN
admet-544	142	8	.	.	PUNCT
admet-544	143	1	interestingly	interestingly	ADV
admet-544	143	2	,	,	PUNCT
admet-544	143	3	the	the	DET
admet-544	143	4	candidate	candidate	NOUN
admet-544	143	5	peptide	peptide	NOUN
admet-544	143	6	drug	drug	NOUN
admet-544	143	7	lp4	lp4	PROPN
admet-544	143	8	has	have	VERB
admet-544	143	9	stronger	strong	ADJ
admet-544	143	10	interactions	interaction	NOUN
admet-544	143	11	with	with	ADP
admet-544	143	12	the	the	DET
admet-544	143	13	phospholipids	phospholipid	NOUN
admet-544	143	14	than	than	SCONJ
admet-544	143	15	the	the	DET
admet-544	143	16	trend	trend	NOUN
admet-544	143	17	would	would	AUX
admet-544	143	18	show	show	VERB
admet-544	143	19	with	with	ADP
admet-544	143	20	the	the	DET
admet-544	143	21	molecular	molecular	ADJ
admet-544	143	22	weight	weight	NOUN
admet-544	143	23	due	due	ADP
admet-544	143	24	to	to	ADP
admet-544	143	25	its	its	PRON
admet-544	143	26	positive	positive	ADJ
admet-544	143	27	charge	charge	NOUN
admet-544	143	28	having	have	VERB
admet-544	143	29	two	two	NUM
admet-544	143	30	arginine	arginine	NOUN
admet-544	143	31	in	in	ADP
admet-544	143	32	its	its	PRON
admet-544	143	33	sequence	sequence	NOUN
admet-544	143	34	.	.	PUNCT
admet-544	144	1	figure	figure	NOUN
admet-544	144	2	5	5	NUM
admet-544	144	3	shows	show	VERB
admet-544	144	4	a	a	DET
admet-544	144	5	similar	similar	ADJ
admet-544	144	6	plot	plot	NOUN
admet-544	144	7	for	for	ADP
admet-544	144	8	the	the	DET
admet-544	144	9	human	human	ADJ
admet-544	144	10	serum	serum	NOUN
admet-544	144	11	albumin	albumin	NOUN
admet-544	144	12	binding	bind	VERB
admet-544	144	13	in	in	ADP
admet-544	144	14	the	the	DET
admet-544	144	15	function	function	NOUN
admet-544	144	16	of	of	ADP
admet-544	144	17	molecular	molecular	ADJ
admet-544	144	18	weight	weight	NOUN
admet-544	144	19	.	.	PUNCT
admet-544	145	1	for	for	ADP
admet-544	145	2	the	the	DET
admet-544	145	3	linear	linear	ADJ
admet-544	145	4	peptides	peptide	NOUN
admet-544	145	5	,	,	PUNCT
admet-544	145	6	as	as	ADP
admet-544	145	7	the	the	DET
admet-544	145	8	amino	amino	NOUN
admet-544	145	9	acid	acid	NOUN
admet-544	145	10	number	number	NOUN
admet-544	145	11	increase	increase	NOUN
admet-544	145	12	,	,	PUNCT
admet-544	145	13	the	the	DET
admet-544	145	14	albumin	albumin	ADJ
admet-544	145	15	binding	bind	VERB
admet-544	145	16	increases	increase	VERB
admet-544	145	17	up	up	ADP
admet-544	145	18	to	to	ADP
admet-544	145	19	lp8	lp8	PRON
admet-544	145	20	.	.	PUNCT
admet-544	146	1	although	although	SCONJ
admet-544	146	2	the	the	DET
admet-544	146	3	albumin	albumin	NOUN
admet-544	146	4	binding	binding	NOUN
admet-544	146	5	is	be	AUX
admet-544	146	6	stronger	strong	ADJ
admet-544	146	7	for	for	ADP
admet-544	146	8	lp8	lp8	PRON
admet-544	146	9	and	and	CCONJ
admet-544	146	10	lp10	lp10	PROPN
admet-544	146	11	,	,	PUNCT
admet-544	146	12	it	it	PRON
admet-544	146	13	does	do	AUX
admet-544	146	14	not	not	PART
admet-544	146	15	increase	increase	VERB
admet-544	146	16	proportionally	proportionally	ADV
admet-544	146	17	with	with	ADP
admet-544	146	18	the	the	DET
admet-544	146	19	molecular	molecular	ADJ
admet-544	146	20	weight	weight	NOUN
admet-544	146	21	.	.	PUNCT
admet-544	147	1	some	some	PRON
admet-544	147	2	of	of	ADP
admet-544	147	3	the	the	DET
admet-544	147	4	bicyclic	bicyclic	ADJ
admet-544	147	5	peptides	peptide	NOUN
admet-544	147	6	showed	show	VERB
admet-544	147	7	much	much	ADV
admet-544	147	8	weaker	weak	ADJ
admet-544	147	9	albumin	albumin	ADJ
admet-544	147	10	binding	binding	NOUN
admet-544	147	11	,	,	PUNCT
admet-544	147	12	probably	probably	ADV
admet-544	147	13	because	because	SCONJ
admet-544	147	14	the	the	DET
admet-544	147	15	cyclization	cyclization	NOUN
admet-544	147	16	hindered	hinder	VERB
admet-544	147	17	several	several	ADJ
admet-544	147	18	amino	amino	ADJ
admet-544	147	19	acids	acid	NOUN
admet-544	147	20	’	'	PUNCT
admet-544	147	21	interactions	interaction	NOUN
admet-544	147	22	with	with	ADP
admet-544	147	23	the	the	DET
admet-544	147	24	protein	protein	NOUN
admet-544	147	25	.	.	PUNCT
admet-544	148	1	almost	almost	ADV
admet-544	148	2	all	all	PRON
admet-544	148	3	of	of	ADP
admet-544	148	4	the	the	DET
admet-544	148	5	bicyclic	bicyclic	ADJ
admet-544	148	6	peptides	peptide	NOUN
admet-544	148	7	showed	show	VERB
admet-544	148	8	wide	wide	ADJ
admet-544	148	9	peaks	peak	NOUN
admet-544	148	10	on	on	ADP
admet-544	148	11	the	the	DET
admet-544	148	12	protein	protein	NOUN
admet-544	148	13	phases	phase	NOUN
admet-544	148	14	indicating	indicate	VERB
admet-544	148	15	multiple	multiple	ADJ
admet-544	148	16	equilibria	equilibrium	NOUN
admet-544	148	17	and	and	CCONJ
admet-544	148	18	sluggish	sluggish	ADJ
admet-544	148	19	kinetics	kinetic	NOUN
admet-544	148	20	.	.	PUNCT
admet-544	149	1	based	base	VERB
admet-544	149	2	on	on	ADP
admet-544	149	3	the	the	DET
admet-544	149	4	measured	measure	VERB
admet-544	149	5	biomimetic	biomimetic	ADJ
admet-544	149	6	properties	property	NOUN
admet-544	149	7	we	we	PRON
admet-544	149	8	have	have	AUX
admet-544	149	9	estimated	estimate	VERB
admet-544	149	10	the	the	DET
admet-544	149	11	in	in	ADP
admet-544	149	12	vivo	vivo	ADJ
admet-544	149	13	distribution	distribution	NOUN
admet-544	149	14	behaviour	behaviour	NOUN
admet-544	149	15	of	of	ADP
admet-544	149	16	the	the	DET
admet-544	149	17	investigated	investigate	VERB
admet-544	149	18	compounds	compound	NOUN
admet-544	149	19	.	.	PUNCT
admet-544	150	1	the	the	DET
admet-544	150	2	model	model	NOUN
admet-544	150	3	equations	equation	NOUN
admet-544	150	4	with	with	ADP
admet-544	150	5	the	the	DET
admet-544	150	6	source	source	NOUN
admet-544	150	7	references	reference	NOUN
admet-544	150	8	are	be	AUX
admet-544	150	9	listed	list	VERB
admet-544	150	10	in	in	ADP
admet-544	150	11	table	table	NOUN
admet-544	150	12	3	3	NUM
admet-544	150	13	.	.	PUNCT
admet-544	150	14	table	table	NOUN
admet-544	150	15	4	4	NUM
admet-544	150	16	contains	contain	VERB
admet-544	150	17	the	the	DET
admet-544	150	18	calculated	calculated	ADJ
admet-544	150	19	total	total	ADJ
admet-544	150	20	plasma	plasma	NOUN
admet-544	150	21	protein	protein	NOUN
admet-544	150	22	binding	bind	VERB
admet-544	150	23	(	(	PUNCT
admet-544	150	24	log	log	NOUN
admet-544	150	25	k	k	PROPN
admet-544	150	26	ppb	ppb	NOUN
admet-544	150	27	)	)	PUNCT
admet-544	150	28	,	,	PUNCT
admet-544	150	29	brain	brain	NOUN
admet-544	150	30	to	to	AUX
admet-544	150	31	plasma	plasma	NOUN
admet-544	150	32	total	total	ADJ
admet-544	150	33	concentration	concentration	NOUN
admet-544	150	34	ratio	ratio	NOUN
admet-544	150	35	(	(	PUNCT
admet-544	150	36	log	log	NOUN
admet-544	150	37	k	k	PROPN
admet-544	150	38	bb	bb	PROPN
admet-544	150	39	,	,	PUNCT
admet-544	150	40	brain	brain	NOUN
admet-544	150	41	to	to	ADP
admet-544	150	42	plasma	plasma	NOUN
admet-544	150	43	ratio	ratio	NOUN
admet-544	150	44	)	)	PUNCT
admet-544	150	45	,	,	PUNCT
admet-544	150	46	volume	volume	NOUN
admet-544	150	47	of	of	ADP
admet-544	150	48	distribution	distribution	NOUN
admet-544	150	49	(	(	PUNCT
admet-544	150	50	log	log	VERB
admet-544	150	51	vdss	vdss	ADV
admet-544	150	52	and	and	CCONJ
admet-544	150	53	vdss	vdss	ADJ
admet-544	150	54	l	l	NOUN
admet-544	150	55	/	/	SYM
admet-544	150	56	kg	kg	PROPN
admet-544	150	57	)	)	PUNCT
admet-544	150	58	,	,	PUNCT
admet-544	150	59	unbound	unbound	NOUN
admet-544	150	60	volume	volume	NOUN
admet-544	150	61	of	of	ADP
admet-544	150	62	distribution	distribution	NOUN
admet-544	150	63	(	(	PUNCT
admet-544	150	64	log	log	PROPN
admet-544	150	65	vdu	vdu	PROPN
admet-544	150	66	,	,	PUNCT
admet-544	150	67	vdu	vdu	PROPN
admet-544	150	68	)	)	PUNCT
admet-544	150	69	,	,	PUNCT
admet-544	150	70	drug	drug	NOUN
admet-544	150	71	efficiency	efficiency	NOUN
admet-544	150	72	(	(	PUNCT
admet-544	150	73	demax%	demax%	NUM
admet-544	150	74	)	)	PUNCT
admet-544	150	75	and	and	CCONJ
admet-544	150	76	estimated	estimate	VERB
admet-544	150	77	cell	cell	NOUN
admet-544	150	78	partition	partition	NOUN
admet-544	150	79	(	(	PUNCT
admet-544	150	80	kpcell	kpcell	NOUN
admet-544	150	81	)	)	PUNCT
admet-544	150	82	data	datum	NOUN
admet-544	150	83	.	.	PUNCT
admet-544	151	1	the	the	DET
admet-544	151	2	brain	brain	NOUN
admet-544	151	3	to	to	AUX
admet-544	151	4	plasma	plasma	VERB
admet-544	151	5	total	total	ADJ
admet-544	151	6	concentration	concentration	NOUN
admet-544	151	7	ratio	ratio	NOUN
admet-544	151	8	has	have	AUX
admet-544	151	9	been	be	AUX
admet-544	151	10	calculated	calculate	VERB
admet-544	151	11	using	use	VERB
admet-544	151	12	the	the	DET
admet-544	151	13	plasma	plasma	NOUN
admet-544	151	14	protein	protein	NOUN
admet-544	151	15	binding	bind	VERB
admet-544	151	16	(	(	PUNCT
admet-544	151	17	%	%	INTJ
admet-544	151	18	ppb	ppb	NOUN
admet-544	151	19	)	)	PUNCT
admet-544	151	20	and	and	CCONJ
admet-544	151	21	brain	brain	NOUN
admet-544	151	22	tissue	tissue	NOUN
admet-544	151	23	binding	bind	VERB
admet-544	151	24	(	(	PUNCT
admet-544	151	25	%	%	INTJ
admet-544	151	26	btb	btb	NOUN
admet-544	151	27	)	)	PUNCT
admet-544	151	28	models	model	NOUN
admet-544	151	29	shown	show	VERB
admet-544	151	30	in	in	ADP
admet-544	151	31	table	table	NOUN
admet-544	151	32	3	3	NUM
admet-544	151	33	and	and	CCONJ
admet-544	151	34	described	describe	VERB
admet-544	151	35	in	in	ADP
admet-544	151	36	[	[	X
admet-544	151	37	35	35	NUM
admet-544	151	38	]	]	PUNCT
admet-544	151	39	.	.	PUNCT
admet-544	152	1	from	from	ADP
admet-544	152	2	the	the	DET
admet-544	152	3	%	%	NOUN
admet-544	152	4	ppb	ppb	NOUN
admet-544	153	1	and	and	CCONJ
admet-544	153	2	%	%	INTJ
admet-544	153	3	btb	btb	INTJ
admet-544	153	4	we	we	PRON
admet-544	153	5	can	can	AUX
admet-544	153	6	calculate	calculate	VERB
admet-544	153	7	the	the	DET
admet-544	153	8	unbound	unbound	NOUN
admet-544	153	9	fraction	fraction	NOUN
admet-544	153	10	of	of	ADP
admet-544	153	11	the	the	DET
admet-544	153	12	peptides	peptide	NOUN
admet-544	153	13	(	(	PUNCT
admet-544	153	14	fu	fu	NOUN
admet-544	153	15	)	)	PUNCT
admet-544	153	16	in	in	ADP
admet-544	153	17	plasma	plasma	NOUN
admet-544	153	18	and	and	CCONJ
admet-544	153	19	brain	brain	NOUN
admet-544	153	20	tissue	tissue	NOUN
admet-544	153	21	using	use	VERB
admet-544	153	22	the	the	DET
admet-544	153	23	equations	equation	NOUN
admet-544	153	24	listed	list	VERB
admet-544	153	25	in	in	ADP
admet-544	153	26	table	table	NOUN
admet-544	153	27	3	3	NUM
admet-544	153	28	.	.	PUNCT
admet-544	154	1	according	accord	VERB
admet-544	154	2	to	to	ADP
admet-544	154	3	the	the	DET
admet-544	154	4	free	free	ADJ
admet-544	154	5	drug	drug	NOUN
admet-544	154	6	hypothesis	hypothesis	NOUN
admet-544	154	7	,	,	PUNCT
admet-544	154	8	the	the	DET
admet-544	154	9	unbound	unbound	NOUN
admet-544	154	10	concentration	concentration	NOUN
admet-544	154	11	in	in	ADP
admet-544	154	12	plasma	plasma	NOUN
admet-544	154	13	(	(	PUNCT
admet-544	154	14	cu	cu	NOUN
admet-544	154	15	,	,	PUNCT
admet-544	154	16	plasma	plasma	NOUN
admet-544	154	17	)	)	PUNCT
admet-544	154	18	and	and	CCONJ
admet-544	154	19	brain	brain	NOUN
admet-544	154	20	(	(	PUNCT
admet-544	154	21	cu	cu	PROPN
admet-544	154	22	,	,	PUNCT
admet-544	154	23	brain	brain	NOUN
admet-544	154	24	)	)	PUNCT
admet-544	154	25	should	should	AUX
admet-544	154	26	be	be	AUX
admet-544	154	27	equal	equal	ADJ
admet-544	154	28	.	.	PUNCT
admet-544	155	1	the	the	DET
admet-544	155	2	unbound	unbound	NOUN
admet-544	155	3	concentrations	concentration	NOUN
admet-544	155	4	can	can	AUX
admet-544	155	5	be	be	AUX
admet-544	155	6	expressed	express	VERB
admet-544	155	7	as	as	ADP
admet-544	155	8	fu	fu	PROPN
admet-544	155	9	klara	klara	PROPN
admet-544	155	10	valko	valko	PROPN
admet-544	155	11	et	et	PROPN
admet-544	155	12	al	al	PROPN
admet-544	155	13	.	.	PROPN
admet-544	155	14	admet	admet	PROPN
admet-544	155	15	&	&	CCONJ
admet-544	155	16	dmpk	dmpk	PROPN
admet-544	155	17	6(2	6(2	NUM
admet-544	155	18	)	)	PUNCT
admet-544	155	19	(	(	PUNCT
admet-544	155	20	2018	2018	NUM
admet-544	155	21	)	)	PUNCT
admet-544	155	22	162	162	NUM
admet-544	155	23	-	-	SYM
admet-544	155	24	175	175	NUM
admet-544	155	25	170	170	NUM
admet-544	155	26	times	time	NOUN
admet-544	155	27	ctotal	ctotal	ADJ
admet-544	155	28	which	which	PRON
admet-544	155	29	leads	lead	VERB
admet-544	155	30	to	to	ADP
admet-544	155	31	equation	equation	NOUN
admet-544	155	32	4	4	NUM
admet-544	155	33	.	.	PUNCT
admet-544	155	34	table	table	NOUN
admet-544	155	35	3	3	NUM
admet-544	155	36	.	.	PUNCT
admet-544	156	1	the	the	DET
admet-544	156	2	model	model	NOUN
admet-544	156	3	equations	equation	NOUN
admet-544	156	4	used	use	VERB
admet-544	156	5	to	to	PART
admet-544	156	6	derive	derive	VERB
admet-544	156	7	estimated	estimate	VERB
admet-544	156	8	in	in	ADP
admet-544	156	9	vivo	vivo	ADJ
admet-544	156	10	distribution	distribution	NOUN
admet-544	156	11	(	(	PUNCT
admet-544	156	12	log	log	VERB
admet-544	156	13	vdss	vdss	ADV
admet-544	156	14	,	,	PUNCT
admet-544	156	15	log	log	PROPN
admet-544	156	16	vdu	vdu	PROPN
admet-544	156	17	)	)	PUNCT
admet-544	156	18	,	,	PUNCT
admet-544	156	19	drug	drug	NOUN
admet-544	156	20	efficiency	efficiency	NOUN
admet-544	156	21	(	(	PUNCT
admet-544	156	22	demax	demax	NOUN
admet-544	156	23	)	)	PUNCT
admet-544	156	24	,	,	PUNCT
admet-544	156	25	brain	brain	NOUN
admet-544	156	26	tissue	tissue	NOUN
admet-544	156	27	binding	bind	VERB
admet-544	156	28	(	(	PUNCT
admet-544	156	29	log	log	NOUN
admet-544	156	30	kbtb	kbtb	NOUN
admet-544	156	31	)	)	PUNCT
admet-544	156	32	,	,	PUNCT
admet-544	156	33	fraction	fraction	NOUN
admet-544	156	34	unbound	unbound	NOUN
admet-544	156	35	in	in	ADP
admet-544	156	36	brain	brain	NOUN
admet-544	156	37	and	and	CCONJ
admet-544	156	38	plasma	plasma	NOUN
admet-544	156	39	(	(	PUNCT
admet-544	156	40	fu	fu	NOUN
admet-544	156	41	btb	btb	NOUN
admet-544	156	42	and	and	CCONJ
admet-544	156	43	fu	fu	ADJ
admet-544	156	44	ppb	ppb	NOUN
admet-544	156	45	)	)	PUNCT
admet-544	156	46	,	,	PUNCT
admet-544	156	47	brain	brain	NOUN
admet-544	156	48	to	to	ADP
admet-544	156	49	plasma	plasma	NOUN
admet-544	156	50	ratio	ratio	NOUN
admet-544	156	51	(	(	PUNCT
admet-544	156	52	kbb	kbb	PROPN
admet-544	156	53	)	)	PUNCT
admet-544	156	54	and	and	CCONJ
admet-544	156	55	cell	cell	NOUN
admet-544	156	56	partition	partition	NOUN
admet-544	156	57	log	log	NOUN
admet-544	156	58	kpcell	kpcell	ADJ
admet-544	156	59	)	)	PUNCT
admet-544	156	60	.	.	PUNCT
admet-544	157	1	log	log	PROPN
admet-544	157	2	kiam	kiam	PROPN
admet-544	158	1	[	[	X
admet-544	158	2	33	33	NUM
admet-544	158	3	]	]	X
admet-544	158	4	=	=	SYM
admet-544	158	5	0.29*e	0.29*e	NUM
admet-544	158	6	(	(	PUNCT
admet-544	158	7	0.026chi(iam)+0.42	0.026chi(iam)+0.42	NUM
admet-544	158	8	)	)	PUNCT
admet-544	158	9	+	+	CCONJ
admet-544	158	10	0.7	0.7	NUM
admet-544	158	11	log	log	NOUN
admet-544	158	12	kiam	kiam	PROPN
admet-544	159	1	[	[	X
admet-544	159	2	33	33	NUM
admet-544	159	3	]	]	X
admet-544	159	4	=	=	SYM
admet-544	159	5	0.046*chi(iam	0.046*chi(iam	NUM
admet-544	159	6	)	)	PUNCT
admet-544	160	1	+	+	CCONJ
admet-544	160	2	0.42	0.42	NUM
admet-544	160	3	log	log	NOUN
admet-544	160	4	khsa	khsa	NOUN
admet-544	161	1	[	[	X
admet-544	161	2	33	33	NUM
admet-544	161	3	]	]	PUNCT
admet-544	161	4	=	=	PUNCT
admet-544	161	5	e	e	X
admet-544	161	6	log	log	NOUN
admet-544	161	7	k(hsa	k(hsa	NOUN
admet-544	161	8	)	)	PUNCT
admet-544	161	9	log	log	NOUN
admet-544	161	10	khsa	khsa	NOUN
admet-544	162	1	[	[	X
admet-544	162	2	34	34	NUM
admet-544	162	3	]	]	X
admet-544	162	4	=	=	PUNCT
admet-544	162	5	log	log	NOUN
admet-544	162	6	(	(	PUNCT
admet-544	162	7	%	%	INTJ
admet-544	162	8	hsabound/(101%hsa	hsabound/(101%hsa	NOUN
admet-544	162	9	bound	bind	VERB
admet-544	162	10	)	)	PUNCT
admet-544	162	11	)	)	PUNCT
admet-544	162	12	estimated	estimate	VERB
admet-544	162	13	log	log	VERB
admet-544	162	14	vdss	vdss	ADV
admet-544	163	1	[	[	X
admet-544	163	2	33	33	NUM
admet-544	163	3	]	]	X
admet-544	163	4	=	=	SYM
admet-544	163	5	0.44*log	0.44*log	PROPN
admet-544	163	6	kiam	kiam	PROPN
admet-544	163	7	-0.22*log	-0.22*log	PROPN
admet-544	163	8	khsa	khsa	PROPN
admet-544	163	9	0.62	0.62	NUM
admet-544	163	10	estimated	estimate	VERB
admet-544	163	11	log	log	NOUN
admet-544	163	12	vdu	vdu	PROPN
admet-544	164	1	[	[	X
admet-544	164	2	38	38	NUM
admet-544	164	3	]	]	PUNCT
admet-544	164	4	=	=	SYM
admet-544	164	5	0.23*log	0.23*log	PROPN
admet-544	164	6	khsa	khsa	PROPN
admet-544	164	7	+0.43*log	+0.43*log	PROPN
admet-544	164	8	kiam	kiam	PROPN
admet-544	164	9	0.72	0.72	NUM
admet-544	164	10	demax	demax	NOUN
admet-544	165	1	[	[	X
admet-544	165	2	39	39	NUM
admet-544	165	3	]	]	PUNCT
admet-544	165	4	=	=	SYM
admet-544	165	5	100	100	NUM
admet-544	165	6	/	/	SYM
admet-544	165	7	vdu	vdu	PROPN
admet-544	165	8	log	log	NOUN
admet-544	165	9	kbtb	kbtb	NOUN
admet-544	165	10	[	[	X
admet-544	165	11	36	36	NUM
admet-544	165	12	]	]	X
admet-544	165	13	=	=	SYM
admet-544	165	14	1.29*log	1.29*log	NUM
admet-544	165	15	kiam+1.03*log	kiam+1.03*log	PROPN
admet-544	165	16	khsa	khsa	VERB
admet-544	165	17	2.37	2.37	NUM
admet-544	165	18	log	log	NOUN
admet-544	165	19	kppb	kppb	PROPN
admet-544	166	1	[	[	X
admet-544	166	2	36	36	NUM
admet-544	166	3	]	]	X
admet-544	166	4	=	=	NOUN
admet-544	166	5	0.98∗log	0.98∗log	NUM
admet-544	166	6	𝑘𝐻𝑆𝐴+0.19∗log	𝑘𝐻𝑆𝐴+0.19∗log	NUM
admet-544	166	7	𝑘𝐴𝐺𝑃+0.031∗chi	𝑘𝐴𝐺𝑃+0.031∗chi	NOUN
admet-544	166	8	log	log	NOUN
admet-544	166	9	d7.4−0.20	d7.4−0.20	NOUN
admet-544	166	10	%	%	INTJ
admet-544	166	11	btb	btb	ADP
admet-544	166	12	[	[	NOUN
admet-544	166	13	36	36	NUM
admet-544	166	14	]	]	X
admet-544	166	15	=	=	NOUN
admet-544	167	1	100	100	NUM
admet-544	167	2	*	*	NUM
admet-544	167	3	10^log	10^log	NUM
admet-544	167	4	kbtb/(1	kbtb/(1	ADJ
admet-544	167	5	+	+	ADJ
admet-544	167	6	10^log	10^log	ADJ
admet-544	167	7	kbtb	kbtb	NOUN
admet-544	167	8	)	)	PUNCT
admet-544	167	9	%	%	NOUN
admet-544	167	10	ppb	ppb	NOUN
admet-544	168	1	[	[	X
admet-544	168	2	36	36	NUM
admet-544	168	3	]	]	X
admet-544	168	4	=	=	NOUN
admet-544	169	1	100	100	NUM
admet-544	169	2	*	*	NUM
admet-544	169	3	10^log	10^log	NUM
admet-544	169	4	kppb/(1	kppb/(1	VERB
admet-544	169	5	+	+	ADJ
admet-544	169	6	10^log	10^log	ADJ
admet-544	169	7	kppb	kppb	NOUN
admet-544	169	8	)	)	PUNCT
admet-544	169	9	fu	fu	NOUN
admet-544	169	10	btb	btb	NOUN
admet-544	169	11	and	and	CCONJ
admet-544	169	12	ppb	ppb	VERB
admet-544	170	1	[	[	X
admet-544	170	2	36	36	NUM
admet-544	170	3	]	]	X
admet-544	170	4	=	=	X
admet-544	170	5	(	(	PUNCT
admet-544	170	6	100-%btb)/100	100-%btb)/100	NUM
admet-544	170	7	and	and	CCONJ
admet-544	170	8	(	(	PUNCT
admet-544	170	9	100-%ppb)/100	100-%ppb)/100	NUM
admet-544	170	10	kbb	kbb	NOUN
admet-544	170	11	[	[	X
admet-544	170	12	36	36	NUM
admet-544	170	13	]	]	X
admet-544	170	14	=	=	SYM
admet-544	170	15	fuppb	fuppb	ADJ
admet-544	170	16	/	/	SYM
admet-544	170	17	fubtb	fubtb	NOUN
admet-544	170	18	log	log	NOUN
admet-544	170	19	kpcell	kpcell	NOUN
admet-544	170	20	[	[	X
admet-544	170	21	35	35	NUM
admet-544	170	22	]	]	X
admet-544	170	23	=	=	PROPN
admet-544	170	24	1.1*log	1.1*log	PROPN
admet-544	170	25	kiam	kiam	PROPN
admet-544	170	26	1.9	1.9	NUM
admet-544	170	27	fu	fu	NOUN
admet-544	170	28	,	,	PUNCT
admet-544	170	29	plasma	plasma	NOUN
admet-544	170	30	x	x	SYM
admet-544	170	31	ct	ct	NOUN
admet-544	170	32	,	,	PUNCT
admet-544	170	33	plasma	plasma	NOUN
admet-544	170	34	=	=	SYM
admet-544	170	35	fu	fu	NOUN
admet-544	170	36	,	,	PUNCT
admet-544	170	37	brain	brain	NOUN
admet-544	170	38	x	x	SYM
admet-544	170	39	ct	ct	PROPN
admet-544	170	40	,	,	PUNCT
admet-544	170	41	brain	brain	NOUN
admet-544	170	42	(	(	PUNCT
admet-544	170	43	4	4	X
admet-544	170	44	)	)	PUNCT
admet-544	170	45	expressing	express	VERB
admet-544	170	46	the	the	DET
admet-544	170	47	ratio	ratio	NOUN
admet-544	170	48	of	of	ADP
admet-544	170	49	the	the	DET
admet-544	170	50	total	total	ADJ
admet-544	170	51	concentrations	concentration	NOUN
admet-544	170	52	from	from	ADP
admet-544	170	53	equation	equation	NOUN
admet-544	170	54	4	4	NUM
admet-544	170	55	,	,	PUNCT
admet-544	170	56	the	the	DET
admet-544	170	57	equation	equation	NOUN
admet-544	170	58	for	for	ADP
admet-544	170	59	kbb	kbb	PROPN
admet-544	170	60	can	can	AUX
admet-544	170	61	be	be	AUX
admet-544	170	62	obtained	obtain	VERB
admet-544	170	63	and	and	CCONJ
admet-544	170	64	is	be	AUX
admet-544	170	65	listed	list	VERB
admet-544	170	66	in	in	ADP
admet-544	170	67	table	table	NOUN
admet-544	170	68	3	3	NUM
admet-544	170	69	.	.	PUNCT
admet-544	171	1	drugs	drug	NOUN
admet-544	171	2	that	that	PRON
admet-544	171	3	are	be	AUX
admet-544	171	4	able	able	ADJ
admet-544	171	5	to	to	PART
admet-544	171	6	go	go	VERB
admet-544	171	7	to	to	ADP
admet-544	171	8	the	the	DET
admet-544	171	9	central	central	ADJ
admet-544	171	10	nervous	nervous	ADJ
admet-544	171	11	system	system	NOUN
admet-544	171	12	(	(	PUNCT
admet-544	171	13	cns	cns	NOUN
admet-544	171	14	)	)	PUNCT
admet-544	171	15	have	have	VERB
admet-544	171	16	significantly	significantly	ADV
admet-544	171	17	higher	high	ADJ
admet-544	171	18	kbb	kbb	PROPN
admet-544	171	19	values	value	NOUN
admet-544	171	20	than	than	ADP
admet-544	171	21	drugs	drug	NOUN
admet-544	171	22	that	that	PRON
admet-544	171	23	do	do	AUX
admet-544	171	24	not	not	PART
admet-544	171	25	partition	partition	VERB
admet-544	171	26	into	into	ADP
admet-544	171	27	the	the	DET
admet-544	171	28	cns	cns	NOUN
admet-544	171	29	.	.	PUNCT
admet-544	172	1	when	when	SCONJ
admet-544	172	2	kbb	kbb	PROPN
admet-544	172	3	is	be	AUX
admet-544	172	4	larger	large	ADJ
admet-544	172	5	than	than	ADP
admet-544	172	6	1	1	NUM
admet-544	172	7	it	it	PRON
admet-544	172	8	means	mean	VERB
admet-544	172	9	that	that	SCONJ
admet-544	172	10	the	the	DET
admet-544	172	11	total	total	ADJ
admet-544	172	12	concentration	concentration	NOUN
admet-544	172	13	of	of	ADP
admet-544	172	14	the	the	DET
admet-544	172	15	compound	compound	NOUN
admet-544	172	16	in	in	ADP
admet-544	172	17	the	the	DET
admet-544	172	18	brain	brain	NOUN
admet-544	172	19	is	be	AUX
admet-544	172	20	higher	high	ADJ
admet-544	172	21	than	than	ADP
admet-544	172	22	in	in	ADP
admet-544	172	23	the	the	DET
admet-544	172	24	plasma	plasma	NOUN
admet-544	172	25	.	.	PUNCT
admet-544	173	1	therefore	therefore	ADV
admet-544	173	2	it	it	PRON
admet-544	173	3	is	be	AUX
admet-544	173	4	very	very	ADV
admet-544	173	5	likely	likely	ADJ
admet-544	173	6	that	that	SCONJ
admet-544	173	7	the	the	DET
admet-544	173	8	compounds	compound	NOUN
admet-544	173	9	partition	partition	NOUN
admet-544	173	10	into	into	ADP
admet-544	173	11	the	the	DET
admet-544	173	12	brain	brain	NOUN
admet-544	173	13	tissue	tissue	NOUN
admet-544	173	14	(	(	PUNCT
admet-544	173	15	unless	unless	SCONJ
admet-544	173	16	active	active	ADJ
admet-544	173	17	transporters	transporter	NOUN
admet-544	173	18	efflux	efflux	VERB
admet-544	173	19	the	the	DET
admet-544	173	20	compound	compound	NOUN
admet-544	173	21	back	back	ADV
admet-544	173	22	to	to	ADP
admet-544	173	23	the	the	DET
admet-544	173	24	plasma	plasma	NOUN
admet-544	173	25	)	)	PUNCT
admet-544	173	26	.	.	PUNCT
admet-544	174	1	as	as	SCONJ
admet-544	174	2	the	the	DET
admet-544	174	3	peptides	peptide	NOUN
admet-544	174	4	easily	easily	ADV
admet-544	174	5	decompose	decompose	VERB
admet-544	174	6	in	in	ADP
admet-544	174	7	plasma	plasma	NOUN
admet-544	174	8	or	or	CCONJ
admet-544	174	9	blood	blood	NOUN
admet-544	174	10	under	under	ADV
admet-544	174	11	in	in	ADP
admet-544	174	12	vitro	vitro	X
admet-544	174	13	experimental	experimental	ADJ
admet-544	174	14	conditions	condition	NOUN
admet-544	174	15	,	,	PUNCT
admet-544	174	16	it	it	PRON
admet-544	174	17	is	be	AUX
admet-544	174	18	very	very	ADV
admet-544	174	19	useful	useful	ADJ
admet-544	174	20	to	to	PART
admet-544	174	21	estimate	estimate	VERB
admet-544	174	22	the	the	DET
admet-544	174	23	peptides	peptide	NOUN
admet-544	174	24	in	in	ADP
admet-544	174	25	vivo	vivo	ADJ
admet-544	174	26	distribution	distribution	NOUN
admet-544	174	27	behaviour	behaviour	NOUN
admet-544	174	28	considering	consider	VERB
admet-544	174	29	them	they	PRON
admet-544	174	30	as	as	ADP
admet-544	174	31	intact	intact	ADJ
admet-544	174	32	molecules	molecule	NOUN
admet-544	174	33	.	.	PUNCT
admet-544	175	1	the	the	DET
admet-544	175	2	data	datum	NOUN
admet-544	175	3	in	in	ADP
admet-544	175	4	table	table	NOUN
admet-544	175	5	4	4	NUM
admet-544	175	6	reveals	reveal	VERB
admet-544	175	7	that	that	SCONJ
admet-544	175	8	there	there	PRON
admet-544	175	9	is	be	VERB
admet-544	175	10	a	a	DET
admet-544	175	11	wide	wide	ADJ
admet-544	175	12	range	range	NOUN
admet-544	175	13	of	of	ADP
admet-544	175	14	estimated	estimate	VERB
admet-544	175	15	total	total	ADJ
admet-544	175	16	plasma	plasma	NOUN
admet-544	175	17	protein	protein	NOUN
admet-544	175	18	binding	bind	VERB
admet-544	175	19	in	in	ADP
admet-544	175	20	spite	spite	NOUN
admet-544	175	21	of	of	ADP
admet-544	175	22	the	the	DET
admet-544	175	23	polar	polar	ADJ
admet-544	175	24	character	character	NOUN
admet-544	175	25	of	of	ADP
admet-544	175	26	the	the	DET
admet-544	175	27	peptides	peptide	NOUN
admet-544	175	28	.	.	PUNCT
admet-544	176	1	the	the	DET
admet-544	176	2	brain	brain	NOUN
admet-544	176	3	to	to	ADP
admet-544	176	4	plasma	plasma	NOUN
admet-544	176	5	distribution	distribution	NOUN
admet-544	176	6	ratio	ratio	NOUN
admet-544	176	7	is	be	AUX
admet-544	176	8	generally	generally	ADV
admet-544	176	9	low	low	ADJ
admet-544	176	10	but	but	CCONJ
admet-544	176	11	some	some	PRON
admet-544	176	12	of	of	ADP
admet-544	176	13	the	the	DET
admet-544	176	14	derivatives	derivative	NOUN
admet-544	176	15	especially	especially	ADV
admet-544	176	16	those	those	PRON
admet-544	176	17	that	that	PRON
admet-544	176	18	have	have	AUX
admet-544	176	19	positively	positively	ADV
admet-544	176	20	charged	charge	VERB
admet-544	176	21	amino	amino	NOUN
admet-544	176	22	acids	acid	NOUN
admet-544	176	23	,	,	PUNCT
admet-544	176	24	particularly	particularly	ADV
admet-544	176	25	with	with	ADP
admet-544	176	26	an	an	DET
admet-544	176	27	arginine	arginine	NOUN
admet-544	176	28	in	in	ADP
admet-544	176	29	the	the	DET
admet-544	176	30	sequence	sequence	NOUN
admet-544	176	31	,	,	PUNCT
admet-544	176	32	bind	bind	VERB
admet-544	176	33	more	more	ADV
admet-544	176	34	strongly	strongly	ADV
admet-544	176	35	to	to	ADP
admet-544	176	36	phospholipids	phospholipid	NOUN
admet-544	176	37	than	than	ADP
admet-544	176	38	to	to	ADP
admet-544	176	39	albumins	albumin	NOUN
admet-544	176	40	thus	thus	ADV
admet-544	176	41	increasing	increase	VERB
admet-544	176	42	the	the	DET
admet-544	176	43	expected	expect	VERB
admet-544	176	44	brain	brain	NOUN
admet-544	176	45	to	to	AUX
admet-544	176	46	plasma	plasma	VERB
admet-544	176	47	total	total	ADJ
admet-544	176	48	concentration	concentration	NOUN
admet-544	176	49	ratio	ratio	NOUN
admet-544	176	50	.	.	PUNCT
admet-544	177	1	the	the	DET
admet-544	177	2	linear	linear	ADJ
admet-544	177	3	peptides	peptide	NOUN
admet-544	177	4	are	be	AUX
admet-544	177	5	designed	design	VERB
admet-544	177	6	as	as	ADP
admet-544	177	7	candidate	candidate	NOUN
admet-544	177	8	therapeutics	therapeutic	NOUN
admet-544	177	9	for	for	ADP
admet-544	177	10	amyotrophic	amyotrophic	ADJ
admet-544	177	11	lateral	lateral	ADJ
admet-544	177	12	sclerosis	sclerosis	NOUN
admet-544	177	13	(	(	PUNCT
admet-544	177	14	als	als	NOUN
admet-544	177	15	)	)	PUNCT
admet-544	177	16	.	.	PUNCT
admet-544	178	1	therefore	therefore	ADV
admet-544	178	2	brain	brain	NOUN
admet-544	178	3	penetration	penetration	NOUN
admet-544	178	4	and	and	CCONJ
admet-544	178	5	cellular	cellular	ADJ
admet-544	178	6	penetration	penetration	NOUN
admet-544	178	7	are	be	AUX
admet-544	178	8	desired	desire	VERB
admet-544	178	9	for	for	ADP
admet-544	178	10	these	these	DET
admet-544	178	11	peptides	peptide	NOUN
admet-544	178	12	.	.	PUNCT
admet-544	179	1	we	we	PRON
admet-544	179	2	can	can	AUX
admet-544	179	3	see	see	VERB
admet-544	179	4	from	from	ADP
admet-544	179	5	the	the	DET
admet-544	179	6	measured	measure	VERB
admet-544	179	7	data	datum	NOUN
admet-544	179	8	that	that	PRON
admet-544	179	9	lp4	lp4	NOUN
admet-544	179	10	(	(	PUNCT
admet-544	179	11	gm6	gm6	PROPN
admet-544	179	12	patented	patent	VERB
admet-544	179	13	by	by	ADP
admet-544	179	14	genervon	genervon	PROPN
admet-544	179	15	)	)	PUNCT
admet-544	179	16	is	be	AUX
admet-544	179	17	predicted	predict	VERB
admet-544	179	18	to	to	PART
admet-544	179	19	have	have	VERB
admet-544	179	20	a	a	DET
admet-544	179	21	good	good	ADJ
admet-544	179	22	brain	brain	NOUN
admet-544	179	23	to	to	ADP
admet-544	179	24	plasma	plasma	NOUN
admet-544	179	25	ratio	ratio	NOUN
admet-544	179	26	.	.	PUNCT
admet-544	180	1	the	the	DET
admet-544	180	2	volume	volume	NOUN
admet-544	180	3	of	of	ADP
admet-544	180	4	distribution	distribution	NOUN
admet-544	180	5	is	be	AUX
admet-544	180	6	also	also	ADV
admet-544	180	7	quite	quite	ADV
admet-544	180	8	large	large	ADJ
admet-544	180	9	which	which	PRON
admet-544	180	10	means	mean	VERB
admet-544	180	11	that	that	SCONJ
admet-544	180	12	it	it	PRON
admet-544	180	13	partitions	partition	VERB
admet-544	180	14	into	into	ADP
admet-544	180	15	tissues	tissue	NOUN
admet-544	180	16	extensively	extensively	ADV
admet-544	180	17	.	.	PUNCT
admet-544	181	1	peptides	peptide	NOUN
admet-544	181	2	that	that	PRON
admet-544	181	3	are	be	AUX
admet-544	181	4	more	more	ADV
admet-544	181	5	lipophilic	lipophilic	ADJ
admet-544	181	6	at	at	ADP
admet-544	181	7	high	high	ADJ
admet-544	181	8	ph	ph	NOUN
admet-544	181	9	(	(	PUNCT
admet-544	181	10	chi	chi	NOUN
admet-544	181	11	log	log	NOUN
admet-544	181	12	d	d	NOUN
admet-544	181	13	at	at	ADP
admet-544	181	14	ph	ph	PROPN
admet-544	181	15	10.5	10.5	NUM
admet-544	181	16	is	be	AUX
admet-544	181	17	greater	great	ADJ
admet-544	181	18	than	than	ADP
admet-544	181	19	chi	chi	PROPN
admet-544	181	20	log	log	NOUN
admet-544	181	21	d	d	NOUN
admet-544	181	22	at	at	ADP
admet-544	181	23	ph	ph	PROPN
admet-544	181	24	7.4	7.4	NUM
admet-544	181	25	)	)	PUNCT
admet-544	181	26	are	be	AUX
admet-544	181	27	predicted	predict	VERB
admet-544	181	28	to	to	PART
admet-544	181	29	have	have	VERB
admet-544	181	30	good	good	ADJ
admet-544	181	31	cell	cell	NOUN
admet-544	181	32	penetration	penetration	NOUN
admet-544	181	33	and	and	CCONJ
admet-544	181	34	the	the	DET
admet-544	181	35	brain	brain	NOUN
admet-544	181	36	to	to	ADP
admet-544	181	37	plasma	plasma	NOUN
admet-544	181	38	ratio	ratio	NOUN
admet-544	181	39	is	be	AUX
admet-544	181	40	predicted	predict	VERB
admet-544	181	41	to	to	PART
admet-544	181	42	be	be	AUX
admet-544	181	43	greater	great	ADJ
admet-544	181	44	than	than	ADP
admet-544	181	45	1	1	NUM
admet-544	181	46	.	.	PUNCT
admet-544	182	1	this	this	PRON
admet-544	182	2	is	be	AUX
admet-544	182	3	because	because	SCONJ
admet-544	182	4	the	the	DET
admet-544	182	5	phospholipid	phospholipid	NOUN
admet-544	182	6	binding	bind	VERB
admet-544	182	7	of	of	ADP
admet-544	182	8	positively	positively	ADV
admet-544	182	9	charged	charge	VERB
admet-544	182	10	peptides	peptide	NOUN
admet-544	182	11	is	be	AUX
admet-544	182	12	stronger	strong	ADJ
admet-544	182	13	than	than	ADP
admet-544	182	14	that	that	PRON
admet-544	182	15	of	of	ADP
admet-544	182	16	the	the	DET
admet-544	182	17	neutral	neutral	ADJ
admet-544	182	18	molecules	molecule	NOUN
admet-544	182	19	.	.	PUNCT
admet-544	183	1	admet	admet	PROPN
admet-544	183	2	&	&	CCONJ
admet-544	183	3	dmpk	dmpk	PROPN
admet-544	183	4	6(2	6(2	NUM
admet-544	183	5	)	)	PUNCT
admet-544	183	6	(	(	PUNCT
admet-544	183	7	2018	2018	NUM
admet-544	183	8	)	)	PUNCT
admet-544	183	9	162	162	NUM
admet-544	183	10	-	-	SYM
admet-544	183	11	175	175	NUM
admet-544	183	12	biomimetic	biomimetic	ADJ
admet-544	183	13	hplc	hplc	NOUN
admet-544	183	14	in	in	ADP
admet-544	183	15	the	the	DET
admet-544	183	16	estimation	estimation	NOUN
admet-544	183	17	of	of	ADP
admet-544	183	18	physchem	physchem	NOUN
admet-544	183	19	properties	property	NOUN
admet-544	183	20	of	of	ADP
admet-544	183	21	peptides	peptide	NOUN
admet-544	183	22	doi	doi	NOUN
admet-544	183	23	:	:	PUNCT
admet-544	183	24	10.5599	10.5599	NUM
admet-544	183	25	/	/	SYM
admet-544	183	26	admet.544	admet.544	PROPN
admet-544	183	27	171	171	NUM
admet-544	183	28	table	table	NOUN
admet-544	183	29	4	4	NUM
admet-544	183	30	.	.	PUNCT
admet-544	183	31	estimated	estimate	VERB
admet-544	183	32	in	in	ADP
admet-544	183	33	vivo	vivo	ADJ
admet-544	183	34	distribution	distribution	NOUN
admet-544	183	35	and	and	CCONJ
admet-544	183	36	tissue	tissue	NOUN
admet-544	183	37	binding	bind	VERB
admet-544	183	38	properties	property	NOUN
admet-544	183	39	of	of	ADP
admet-544	183	40	the	the	DET
admet-544	183	41	investigated	investigate	VERB
admet-544	183	42	peptides	peptide	NOUN
admet-544	183	43	.	.	PUNCT
admet-544	184	1	peptide	peptide	NOUN
admet-544	184	2	%	%	NOUN
admet-544	184	3	bound	bind	VERB
admet-544	184	4	ppb	ppb	NOUN
admet-544	184	5	log	log	NOUN
admet-544	184	6	k	k	PROPN
admet-544	184	7	ppb	ppb	NOUN
admet-544	184	8	log	log	NOUN
admet-544	184	9	k	k	PROPN
admet-544	184	10	bb	bb	NOUN
admet-544	184	11	brain	brain	NOUN
admet-544	184	12	to	to	AUX
admet-544	184	13	plasma	plasma	NOUN
admet-544	184	14	log	log	NOUN
admet-544	184	15	vd	vd	NOUN
admet-544	184	16	vd	vd	X
admet-544	184	17	l	l	X
admet-544	184	18	/	/	SYM
admet-544	184	19	kg	kg	PROPN
admet-544	184	20	log	log	NOUN
admet-544	184	21	vdu	vdu	PROPN
admet-544	184	22	vdu	vdu	PROPN
admet-544	184	23	%	%	NOUN
admet-544	185	1	demax	demax	NOUN
admet-544	185	2	kpcell	kpcell	PROPN
admet-544	185	3	lp1	lp1	PROPN
admet-544	185	4	6.85	6.85	NUM
admet-544	185	5	-1.14	-1.14	PRON
admet-544	185	6	-0.03	-0.03	NUM
admet-544	185	7	0.93	0.93	NUM
admet-544	185	8	-0.18	-0.18	NUM
admet-544	185	9	0.66	0.66	NUM
admet-544	185	10	-0.10	-0.10	NUM
admet-544	185	11	0.80	0.80	NUM
admet-544	185	12	124.83	124.83	NUM
admet-544	185	13	0.07	0.07	NUM
admet-544	185	14	lp2	lp2	PROPN
admet-544	185	15	13.36	13.36	NUM
admet-544	185	16	-0.82	-0.82	X
admet-544	185	17	-0.05	-0.05	NUM
admet-544	185	18	0.88	0.88	NUM
admet-544	185	19	-0.06	-0.06	NUM
admet-544	185	20	0.88	0.88	NUM
admet-544	185	21	0.07	0.07	NUM
admet-544	185	22	1.17	1.17	NUM
admet-544	185	23	85.62	85.62	NUM
admet-544	185	24	0.22	0.22	NUM
admet-544	185	25	lp3	lp3	NOUN
admet-544	185	26	13.03	13.03	NUM
admet-544	185	27	-0.83	-0.83	NOUN
admet-544	185	28	-0.05	-0.05	NUM
admet-544	185	29	0.89	0.89	NUM
admet-544	185	30	-0.01	-0.01	NUM
admet-544	185	31	0.97	0.97	NUM
admet-544	185	32	0.11	0.11	NUM
admet-544	185	33	1.27	1.27	NUM
admet-544	185	34	78.44	78.44	NUM
admet-544	185	35	0.28	0.28	NUM
admet-544	185	36	lp4	lp4	NOUN
admet-544	185	37	36.55	36.55	NUM
admet-544	185	38	-0.25	-0.25	NUM
admet-544	185	39	0.23	0.23	NUM
admet-544	185	40	1.70	1.70	NUM
admet-544	185	41	0.92	0.92	NUM
admet-544	185	42	8.29	8.29	NUM
admet-544	185	43	1.10	1.10	NUM
admet-544	185	44	12.49	12.49	NUM
admet-544	185	45	8.00	8.00	NUM
admet-544	185	46	5.49	5.49	NUM
admet-544	185	47	lp5	lp5	NOUN
admet-544	185	48	27.63	27.63	NUM
admet-544	185	49	-0.42	-0.42	NUM
admet-544	185	50	0.20	0.20	NUM
admet-544	185	51	1.58	1.58	NUM
admet-544	185	52	0.88	0.88	NUM
admet-544	185	53	7.62	7.62	NUM
admet-544	185	54	1.03	1.03	NUM
admet-544	185	55	10.82	10.82	NUM
admet-544	185	56	9.25	9.25	NUM
admet-544	185	57	5.01	5.01	NUM
admet-544	185	58	lp6	lp6	NOUN
admet-544	185	59	85.20	85.20	NUM
admet-544	185	60	0.73	0.73	NUM
admet-544	185	61	-0.39	-0.39	NUM
admet-544	185	62	0.40	0.40	NUM
admet-544	185	63	-0.08	-0.08	NUM
admet-544	185	64	0.82	0.82	NUM
admet-544	185	65	0.59	0.59	NUM
admet-544	185	66	3.89	3.89	NUM
admet-544	185	67	25.70	25.70	NUM
admet-544	185	68	0.74	0.74	NUM
admet-544	185	69	lp7	lp7	X
admet-544	185	70	68.47	68.47	NUM
admet-544	185	71	0.32	0.32	NUM
admet-544	185	72	0.34	0.34	NUM
admet-544	185	73	2.21	2.21	NUM
admet-544	185	74	0.84	0.84	NUM
admet-544	185	75	6.96	6.96	NUM
admet-544	185	76	1.21	1.21	NUM
admet-544	185	77	16.23	16.23	NUM
admet-544	185	78	6.16	6.16	NUM
admet-544	185	79	5.66	5.66	NUM
admet-544	185	80	lp8	lp8	NOUN
admet-544	185	81	98.17	98.17	NUM
admet-544	185	82	1.54	1.54	NUM
admet-544	185	83	-0.04	-0.04	NUM
admet-544	185	84	0.92	0.92	NUM
admet-544	185	85	-0.04	-0.04	NUM
admet-544	185	86	0.91	0.91	NUM
admet-544	185	87	1.46	1.46	NUM
admet-544	185	88	28.62	28.62	NUM
admet-544	185	89	3.49	3.49	NUM
admet-544	185	90	2.87	2.87	NUM
admet-544	185	91	lp9	lp9	NOUN
admet-544	185	92	99.99	99.99	NUM
admet-544	185	93	2.00	2.00	NUM
admet-544	185	94	-1.49	-1.49	NUM
admet-544	185	95	0.03	0.03	NUM
admet-544	185	96	-0.08	-0.08	NUM
admet-544	185	97	0.82	0.82	NUM
admet-544	185	98	2.25	2.25	NUM
admet-544	185	99	176.76	176.76	NUM
admet-544	185	100	0.57	0.57	NUM
admet-544	185	101	6.00	6.00	NUM
admet-544	185	102	lp10	lp10	PROPN
admet-544	185	103	99.99	99.99	NUM
admet-544	185	104	2.00	2.00	NUM
admet-544	185	105	-1.83	-1.83	NOUN
admet-544	185	106	0.01	0.01	NUM
admet-544	185	107	-0.47	-0.47	DET
admet-544	185	108	0.34	0.34	NUM
admet-544	185	109	1.92	1.92	NUM
admet-544	185	110	84.13	84.13	NUM
admet-544	185	111	1.19	1.19	NUM
admet-544	185	112	2.93	2.93	NUM
admet-544	185	113	bcp1	bcp1	NOUN
admet-544	185	114	81.77	81.77	NUM
admet-544	185	115	0.63	0.63	NUM
admet-544	185	116	-0.25	-0.25	NUM
admet-544	185	117	0.25	0.25	NUM
admet-544	185	118	-0.26	-0.26	NOUN
admet-544	185	119	0.55	0.55	NUM
admet-544	185	120	0.32	0.32	NUM
admet-544	185	121	2.10	2.10	NUM
admet-544	185	122	47.56	47.56	NUM
admet-544	185	123	0.25	0.25	NUM
admet-544	185	124	bcp2	bcp2	NOUN
admet-544	185	125	84.04	84.04	NUM
admet-544	185	126	0.70	0.70	NUM
admet-544	185	127	0.19	0.19	NUM
admet-544	185	128	0.36	0.36	NUM
admet-544	185	129	-0.43	-0.43	NUM
admet-544	185	130	0.37	0.37	NUM
admet-544	185	131	0.55	0.55	NUM
admet-544	185	132	3.56	3.56	NUM
admet-544	185	133	28.06	28.06	NUM
admet-544	185	134	0.29	0.29	NUM
admet-544	185	135	bcp3	bcp3	PROPN
admet-544	185	136	14.84	14.84	NUM
admet-544	185	137	-0.76	-0.76	PROPN
admet-544	185	138	-0.01	-0.01	NUM
admet-544	185	139	0.88	0.88	NUM
admet-544	185	140	-0.06	-0.06	NUM
admet-544	185	141	0.87	0.87	NUM
admet-544	185	142	0.10	0.10	NUM
admet-544	185	143	1.26	1.26	NUM
admet-544	185	144	79.24	79.24	NUM
admet-544	185	145	0.24	0.24	NUM
admet-544	185	146	bcp4	bcp4	NOUN
admet-544	185	147	25.70	25.70	NUM
admet-544	185	148	-0.47	-0.47	PRON
admet-544	185	149	-0.03	-0.03	NUM
admet-544	185	150	0.94	0.94	NUM
admet-544	185	151	0.40	0.40	NUM
admet-544	185	152	2.51	2.51	NUM
admet-544	185	153	0.55	0.55	NUM
admet-544	185	154	3.51	3.51	NUM
admet-544	185	155	28.47	28.47	NUM
admet-544	185	156	1.60	1.60	NUM
admet-544	185	157	bcp5	bcp5	NOUN
admet-544	185	158	96.85	96.85	NUM
admet-544	185	159	1.37	1.37	NUM
admet-544	185	160	0.52	0.52	NUM
admet-544	185	161	1.40	1.40	NUM
admet-544	185	162	0.23	0.23	NUM
admet-544	185	163	1.72	1.72	NUM
admet-544	185	164	1.44	1.44	NUM
admet-544	185	165	27.51	27.51	NUM
admet-544	185	166	3.64	3.64	NUM
admet-544	185	167	3.85	3.85	NUM
admet-544	185	168	bcp6	bcp6	NOUN
admet-544	185	169	23.29	23.29	NUM
admet-544	185	170	-0.52	-0.52	NUM
admet-544	185	171	0.00	0.00	NUM
admet-544	185	172	0.84	0.84	NUM
admet-544	185	173	0.04	0.04	NUM
admet-544	185	174	1.09	1.09	NUM
admet-544	185	175	0.24	0.24	NUM
admet-544	185	176	1.75	1.75	NUM
admet-544	185	177	57.17	57.17	NUM
admet-544	185	178	0.46	0.46	NUM
admet-544	185	179	bcp7	bcp7	NOUN
admet-544	185	180	7.46	7.46	NUM
admet-544	185	181	-1.10	-1.10	NOUN
admet-544	185	182	-0.02	-0.02	NUM
admet-544	185	183	0.94	0.94	NUM
admet-544	185	184	0.01	0.01	NUM
admet-544	185	185	1.03	1.03	NUM
admet-544	185	186	0.10	0.10	NUM
admet-544	185	187	1.26	1.26	NUM
admet-544	185	188	79.11	79.11	NUM
admet-544	185	189	0.30	0.30	NUM
admet-544	185	190	bcp8	bcp8	PROPN
admet-544	185	191	97.98	97.98	NUM
admet-544	185	192	1.51	1.51	NUM
admet-544	185	193	0.63	0.63	NUM
admet-544	185	194	2.17	2.17	NUM
admet-544	185	195	0.48	0.48	NUM
admet-544	185	196	3.03	3.03	NUM
admet-544	185	197	1.81	1.81	NUM
admet-544	185	198	64.42	64.42	NUM
admet-544	185	199	1.55	1.55	NUM
admet-544	185	200	6.82	6.82	NUM
admet-544	185	201	bcp9	bcp9	PROPN
admet-544	185	202	87.21	87.21	NUM
admet-544	185	203	0.80	0.80	NUM
admet-544	185	204	0.11	0.11	NUM
admet-544	185	205	0.43	0.43	NUM
admet-544	185	206	-0.13	-0.13	NUM
admet-544	185	207	0.74	0.74	NUM
admet-544	185	208	0.64	0.64	NUM
admet-544	185	209	4.40	4.40	NUM
admet-544	185	210	22.72	22.72	NUM
admet-544	185	211	0.75	0.75	NUM
admet-544	185	212	bcp10	bcp10	NOUN
admet-544	185	213	97.97	97.97	NUM
admet-544	185	214	1.51	1.51	NUM
admet-544	185	215	-0.38	-0.38	NUM
admet-544	185	216	0.15	0.15	NUM
admet-544	185	217	-0.64	-0.64	NUM
admet-544	185	218	0.23	0.23	NUM
admet-544	185	219	0.94	0.94	NUM
admet-544	185	220	8.77	8.77	NUM
admet-544	185	221	11.40	11.40	NUM
admet-544	185	222	0.45	0.45	NUM
admet-544	185	223	cp	cp	NUM
admet-544	185	224	100	100	NUM
admet-544	185	225	2.00	2.00	NUM
admet-544	185	226	0.78	0.78	NUM
admet-544	185	227	5.63	5.63	NUM
admet-544	185	228	1.13	1.13	NUM
admet-544	185	229	13.39	13.39	NUM
admet-544	185	230	2.20	2.20	NUM
admet-544	185	231	158	158	NUM
admet-544	185	232	0.68	0.68	NUM
admet-544	185	233	14.43	14.43	NUM
admet-544	185	234	it	it	PRON
admet-544	185	235	is	be	AUX
admet-544	185	236	well	well	ADV
admet-544	185	237	known	know	VERB
admet-544	185	238	that	that	SCONJ
admet-544	185	239	cell	cell	NOUN
admet-544	185	240	penetration	penetration	NOUN
admet-544	185	241	of	of	ADP
admet-544	185	242	peptides	peptide	NOUN
admet-544	185	243	is	be	AUX
admet-544	185	244	usually	usually	ADV
admet-544	185	245	impaired	impair	VERB
admet-544	185	246	,	,	PUNCT
admet-544	185	247	as	as	SCONJ
admet-544	185	248	they	they	PRON
admet-544	185	249	are	be	AUX
admet-544	185	250	very	very	ADV
admet-544	185	251	hydrophilic	hydrophilic	ADJ
admet-544	185	252	and	and	CCONJ
admet-544	185	253	can	can	AUX
admet-544	185	254	not	not	PART
admet-544	185	255	go	go	VERB
admet-544	185	256	through	through	ADP
admet-544	185	257	the	the	DET
admet-544	185	258	cell	cell	NOUN
admet-544	185	259	membrane	membrane	NOUN
admet-544	185	260	with	with	ADP
admet-544	185	261	the	the	DET
admet-544	185	262	same	same	ADJ
admet-544	185	263	mechanism	mechanism	NOUN
admet-544	185	264	as	as	ADP
admet-544	185	265	small	small	ADJ
admet-544	185	266	molecules	molecule	NOUN
admet-544	185	267	[	[	X
admet-544	185	268	8	8	NUM
admet-544	185	269	]	]	PUNCT
admet-544	185	270	.	.	PUNCT
admet-544	186	1	however	however	ADV
admet-544	186	2	,	,	PUNCT
admet-544	186	3	endocytosis	endocytosis	NOUN
admet-544	186	4	or	or	CCONJ
admet-544	186	5	micelle	micelle	NOUN
admet-544	186	6	formation	formation	NOUN
admet-544	186	7	with	with	ADP
admet-544	186	8	phospholipids	phospholipid	NOUN
admet-544	186	9	are	be	AUX
admet-544	186	10	possible	possible	ADJ
admet-544	186	11	cell	cell	NOUN
admet-544	186	12	penetration	penetration	NOUN
admet-544	186	13	mechanisms	mechanism	NOUN
admet-544	186	14	which	which	PRON
admet-544	186	15	require	require	VERB
admet-544	186	16	strong	strong	ADJ
admet-544	186	17	interactions	interaction	NOUN
admet-544	186	18	between	between	ADP
admet-544	186	19	the	the	DET
admet-544	186	20	peptides	peptide	NOUN
admet-544	186	21	and	and	CCONJ
admet-544	186	22	the	the	DET
admet-544	186	23	phospholipid	phospholipid	NOUN
admet-544	186	24	membrane	membrane	NOUN
admet-544	186	25	.	.	PUNCT
admet-544	187	1	the	the	DET
admet-544	187	2	model	model	NOUN
admet-544	187	3	for	for	ADP
admet-544	187	4	cell	cell	NOUN
admet-544	187	5	partition	partition	NOUN
admet-544	187	6	has	have	AUX
admet-544	187	7	been	be	AUX
admet-544	187	8	investigated	investigate	VERB
admet-544	187	9	using	use	VERB
admet-544	187	10	small	small	ADJ
admet-544	187	11	molecule	molecule	NOUN
admet-544	187	12	partition	partition	NOUN
admet-544	187	13	into	into	ADP
admet-544	187	14	hela	hela	ADJ
admet-544	187	15	cells	cell	NOUN
admet-544	187	16	[	[	X
admet-544	187	17	35	35	NUM
admet-544	187	18	]	]	PUNCT
admet-544	187	19	and	and	CCONJ
admet-544	187	20	it	it	PRON
admet-544	187	21	was	be	AUX
admet-544	187	22	found	find	VERB
admet-544	187	23	that	that	SCONJ
admet-544	187	24	the	the	DET
admet-544	187	25	iam	iam	PROPN
admet-544	187	26	partition	partition	NOUN
admet-544	187	27	correlated	correlate	VERB
admet-544	187	28	better	well	ADV
admet-544	187	29	with	with	ADP
admet-544	187	30	intracellular	intracellular	ADJ
admet-544	187	31	concentration	concentration	NOUN
admet-544	187	32	than	than	ADP
admet-544	187	33	other	other	ADJ
admet-544	187	34	lipophilicity	lipophilicity	NOUN
admet-544	187	35	values	value	NOUN
admet-544	187	36	.	.	PUNCT
admet-544	188	1	therefore	therefore	ADV
admet-544	188	2	,	,	PUNCT
admet-544	188	3	the	the	DET
admet-544	188	4	cell	cell	NOUN
admet-544	188	5	partition	partition	NOUN
admet-544	188	6	(	(	PUNCT
admet-544	188	7	kp	kp	PROPN
admet-544	188	8	cell	cell	PROPN
admet-544	188	9	)	)	PUNCT
admet-544	188	10	has	have	AUX
admet-544	188	11	been	be	AUX
admet-544	188	12	estimated	estimate	VERB
admet-544	188	13	using	use	VERB
admet-544	188	14	the	the	DET
admet-544	188	15	correlation	correlation	NOUN
admet-544	188	16	with	with	ADP
admet-544	188	17	the	the	DET
admet-544	188	18	iam	iam	PROPN
admet-544	188	19	retention	retention	NOUN
admet-544	188	20	.	.	PUNCT
admet-544	189	1	although	although	SCONJ
admet-544	189	2	the	the	DET
admet-544	189	3	distribution	distribution	NOUN
admet-544	189	4	models	model	NOUN
admet-544	189	5	have	have	AUX
admet-544	189	6	been	be	AUX
admet-544	189	7	developed	develop	VERB
admet-544	189	8	using	use	VERB
admet-544	189	9	the	the	DET
admet-544	189	10	properties	property	NOUN
admet-544	189	11	of	of	ADP
admet-544	189	12	small	small	ADJ
admet-544	189	13	molecule	molecule	NOUN
admet-544	189	14	marketed	market	VERB
admet-544	189	15	drugs	drug	NOUN
admet-544	189	16	based	base	VERB
admet-544	189	17	on	on	ADP
admet-544	189	18	their	their	PRON
admet-544	189	19	clinical	clinical	ADJ
admet-544	189	20	data	datum	NOUN
admet-544	189	21	,	,	PUNCT
admet-544	189	22	it	it	PRON
admet-544	189	23	was	be	AUX
admet-544	189	24	supposed	suppose	VERB
admet-544	189	25	that	that	SCONJ
admet-544	189	26	the	the	DET
admet-544	189	27	same	same	ADJ
admet-544	189	28	models	model	NOUN
admet-544	189	29	could	could	AUX
admet-544	189	30	be	be	AUX
admet-544	189	31	applied	apply	VERB
admet-544	189	32	to	to	ADP
admet-544	189	33	peptides	peptide	NOUN
admet-544	189	34	.	.	PUNCT
admet-544	190	1	diaz	diaz	PROPN
admet-544	190	2	-	-	PUNCT
admet-544	190	3	eufracio	eufracio	PROPN
admet-544	190	4	et	et	PROPN
admet-544	190	5	al	al	PROPN
admet-544	191	1	[	[	X
admet-544	191	2	40	40	NUM
admet-544	191	3	]	]	PUNCT
admet-544	191	4	have	have	AUX
admet-544	191	5	compared	compare	VERB
admet-544	191	6	the	the	DET
admet-544	191	7	physicochemical	physicochemical	ADJ
admet-544	191	8	property	property	NOUN
admet-544	191	9	space	space	NOUN
admet-544	191	10	of	of	ADP
admet-544	191	11	marketed	market	VERB
admet-544	191	12	peptide	peptide	ADJ
admet-544	191	13	therapeutics	therapeutic	NOUN
admet-544	191	14	with	with	ADP
admet-544	191	15	other	other	ADJ
admet-544	191	16	marketed	market	VERB
admet-544	191	17	drugs	drug	NOUN
admet-544	191	18	and	and	CCONJ
admet-544	191	19	they	they	PRON
admet-544	191	20	found	find	VERB
admet-544	191	21	that	that	SCONJ
admet-544	191	22	they	they	PRON
admet-544	191	23	occupy	occupy	VERB
admet-544	191	24	similar	similar	ADJ
admet-544	191	25	property	property	NOUN
admet-544	191	26	space	space	NOUN
admet-544	191	27	.	.	PUNCT
admet-544	192	1	this	this	DET
admet-544	192	2	study	study	NOUN
admet-544	192	3	suggests	suggest	VERB
admet-544	192	4	that	that	SCONJ
admet-544	192	5	physicochemical	physicochemical	ADJ
admet-544	192	6	properties	property	NOUN
admet-544	192	7	of	of	ADP
admet-544	192	8	the	the	DET
admet-544	192	9	peptides	peptide	NOUN
admet-544	192	10	are	be	AUX
admet-544	192	11	not	not	PART
admet-544	192	12	significantly	significantly	ADV
admet-544	192	13	different	different	ADJ
admet-544	192	14	from	from	ADP
admet-544	192	15	small	small	ADJ
admet-544	192	16	molecule	molecule	NOUN
admet-544	192	17	marketed	market	VERB
admet-544	192	18	drugs	drug	NOUN
admet-544	192	19	and	and	CCONJ
admet-544	192	20	the	the	DET
admet-544	192	21	drug	drug	NOUN
admet-544	192	22	-	-	PUNCT
admet-544	192	23	like	like	ADJ
admet-544	192	24	properties	property	NOUN
admet-544	192	25	can	can	AUX
admet-544	192	26	be	be	AUX
admet-544	192	27	described	describe	VERB
admet-544	192	28	by	by	ADP
admet-544	192	29	the	the	DET
admet-544	192	30	same	same	ADJ
admet-544	192	31	physicochemical	physicochemical	ADJ
admet-544	192	32	properties	property	NOUN
admet-544	192	33	.	.	PUNCT
admet-544	193	1	they	they	PRON
admet-544	193	2	used	use	VERB
admet-544	193	3	calculated	calculate	VERB
admet-544	193	4	physicochemical	physicochemical	ADJ
admet-544	193	5	properties	property	NOUN
admet-544	193	6	.	.	PUNCT
admet-544	194	1	in	in	ADP
admet-544	194	2	this	this	DET
admet-544	194	3	study	study	NOUN
admet-544	194	4	,	,	PUNCT
admet-544	194	5	the	the	DET
admet-544	194	6	measured	measure	VERB
admet-544	194	7	physicochemical	physicochemical	ADJ
admet-544	194	8	and	and	CCONJ
admet-544	194	9	biomimetic	biomimetic	ADJ
admet-544	194	10	properties	property	NOUN
admet-544	194	11	are	be	AUX
admet-544	194	12	compared	compare	VERB
admet-544	194	13	with	with	ADP
admet-544	194	14	marketed	market	VERB
admet-544	194	15	drugs	drug	NOUN
admet-544	194	16	[	[	X
admet-544	194	17	36	36	NUM
admet-544	194	18	]	]	PUNCT
admet-544	194	19	and	and	CCONJ
admet-544	194	20	macrolides	macrolide	NOUN
admet-544	194	21	[	[	X
admet-544	194	22	41	41	NUM
admet-544	194	23	]	]	PUNCT
admet-544	194	24	.	.	PUNCT
admet-544	195	1	the	the	DET
admet-544	195	2	marketed	market	VERB
admet-544	195	3	drugs	drug	NOUN
admet-544	195	4	were	be	AUX
admet-544	195	5	divided	divide	VERB
admet-544	195	6	into	into	ADP
admet-544	195	7	inhaled	inhaled	ADJ
admet-544	195	8	and	and	CCONJ
admet-544	195	9	cns	cns	NOUN
admet-544	195	10	group	group	NOUN
admet-544	195	11	.	.	PUNCT
admet-544	196	1	a	a	DET
admet-544	196	2	cyclic	cyclic	ADJ
admet-544	196	3	peptide	peptide	NOUN
admet-544	196	4	natural	natural	ADJ
admet-544	196	5	product	product	NOUN
admet-544	196	6	drug	drug	NOUN
admet-544	196	7	cyclosporine	cyclosporine	NOUN
admet-544	196	8	(	(	PUNCT
admet-544	196	9	marked	mark	VERB
admet-544	196	10	as	as	ADP
admet-544	196	11	cp	cp	PROPN
admet-544	196	12	)	)	PUNCT
admet-544	196	13	was	be	AUX
admet-544	196	14	also	also	ADV
admet-544	196	15	included	include	VERB
admet-544	196	16	in	in	ADP
admet-544	196	17	the	the	DET
admet-544	196	18	analysis	analysis	NOUN
admet-544	196	19	.	.	PUNCT
admet-544	197	1	figure	figure	NOUN
admet-544	197	2	6a	6a	NOUN
admet-544	197	3	shows	show	VERB
admet-544	197	4	the	the	DET
admet-544	197	5	lipophilicity	lipophilicity	NOUN
admet-544	197	6	distribution	distribution	NOUN
admet-544	197	7	and	and	CCONJ
admet-544	197	8	figure	figure	NOUN
admet-544	197	9	6b	6b	NOUN
admet-544	197	10	shows	show	VERB
admet-544	197	11	the	the	DET
admet-544	197	12	iam	iam	PROPN
admet-544	197	13	binding	bind	VERB
admet-544	197	14	distribution	distribution	NOUN
admet-544	197	15	of	of	ADP
admet-544	197	16	the	the	DET
admet-544	197	17	peptides	peptide	NOUN
admet-544	197	18	and	and	CCONJ
admet-544	197	19	the	the	DET
admet-544	197	20	marketed	market	VERB
admet-544	197	21	drugs	drug	NOUN
admet-544	197	22	.	.	PUNCT
admet-544	198	1	it	it	PRON
admet-544	198	2	can	can	AUX
admet-544	198	3	be	be	AUX
admet-544	198	4	seen	see	VERB
admet-544	198	5	that	that	SCONJ
admet-544	198	6	the	the	DET
admet-544	198	7	peptides	peptide	NOUN
admet-544	198	8	are	be	AUX
admet-544	198	9	less	less	ADV
admet-544	198	10	lipophilic	lipophilic	ADJ
admet-544	198	11	but	but	CCONJ
admet-544	198	12	their	their	PRON
admet-544	198	13	membrane	membrane	NOUN
admet-544	198	14	partition	partition	NOUN
admet-544	198	15	(	(	PUNCT
admet-544	198	16	iam	iam	PROPN
admet-544	198	17	binding	bind	VERB
admet-544	198	18	)	)	PUNCT
admet-544	198	19	is	be	AUX
admet-544	198	20	within	within	ADP
admet-544	198	21	the	the	DET
admet-544	198	22	range	range	NOUN
admet-544	198	23	of	of	ADP
admet-544	198	24	other	other	ADJ
admet-544	198	25	drug	drug	NOUN
admet-544	198	26	molecules	molecule	NOUN
admet-544	198	27	.	.	PUNCT
admet-544	199	1	klara	klara	PROPN
admet-544	199	2	valko	valko	PROPN
admet-544	199	3	et	et	PROPN
admet-544	199	4	al	al	PROPN
admet-544	199	5	.	.	PROPN
admet-544	199	6	admet	admet	PROPN
admet-544	199	7	&	&	CCONJ
admet-544	199	8	dmpk	dmpk	PROPN
admet-544	199	9	6(2	6(2	NUM
admet-544	199	10	)	)	PUNCT
admet-544	199	11	(	(	PUNCT
admet-544	199	12	2018	2018	NUM
admet-544	199	13	)	)	PUNCT
admet-544	199	14	162	162	NUM
admet-544	199	15	-	-	SYM
admet-544	199	16	175	175	NUM
admet-544	199	17	172	172	NUM
admet-544	199	18	a	a	DET
admet-544	199	19	)	)	PUNCT
admet-544	199	20	b	b	NOUN
admet-544	199	21	)	)	PUNCT
admet-544	199	22	figure	figure	NOUN
admet-544	199	23	6	6	NUM
admet-544	199	24	.	.	PUNCT
admet-544	200	1	the	the	DET
admet-544	200	2	lipophilicity	lipophilicity	NOUN
admet-544	200	3	(	(	PUNCT
admet-544	200	4	chi	chi	NOUN
admet-544	200	5	log	log	NOUN
admet-544	200	6	d7.4	d7.4	PROPN
admet-544	200	7	)	)	PUNCT
admet-544	200	8	(	(	PUNCT
admet-544	200	9	a	a	NOUN
admet-544	200	10	)	)	PUNCT
admet-544	200	11	and	and	CCONJ
admet-544	200	12	membrane	membrane	NOUN
admet-544	200	13	partition	partition	NOUN
admet-544	200	14	(	(	PUNCT
admet-544	200	15	chi	chi	PROPN
admet-544	200	16	iam	iam	PROPN
admet-544	200	17	)	)	PUNCT
admet-544	200	18	(	(	PUNCT
admet-544	200	19	b	b	NOUN
admet-544	200	20	)	)	PUNCT
admet-544	200	21	,	,	PUNCT
admet-544	200	22	of	of	ADP
admet-544	200	23	the	the	DET
admet-544	200	24	peptides	peptide	NOUN
admet-544	200	25	in	in	ADP
admet-544	200	26	comparison	comparison	NOUN
admet-544	200	27	to	to	ADP
admet-544	200	28	macrocycle	macrocycle	NOUN
admet-544	200	29	(	(	PUNCT
admet-544	200	30	mc	mc	PROPN
admet-544	200	31	)	)	PUNCT
admet-544	200	32	,	,	PUNCT
admet-544	200	33	small	small	ADJ
admet-544	200	34	molecule	molecule	NOUN
admet-544	200	35	drugs	drug	NOUN
admet-544	200	36	(	(	PUNCT
admet-544	200	37	drug	drug	NOUN
admet-544	200	38	)	)	PUNCT
admet-544	200	39	,	,	PUNCT
admet-544	200	40	inhaled	inhale	VERB
admet-544	200	41	drugs	drug	NOUN
admet-544	200	42	and	and	CCONJ
admet-544	200	43	drugs	drug	NOUN
admet-544	200	44	that	that	PRON
admet-544	200	45	can	can	AUX
admet-544	200	46	go	go	VERB
admet-544	200	47	to	to	ADP
admet-544	200	48	the	the	DET
admet-544	200	49	central	central	ADJ
admet-544	200	50	nervous	nervous	ADJ
admet-544	200	51	system	system	NOUN
admet-544	200	52	(	(	PUNCT
admet-544	200	53	cns	cns	NOUN
admet-544	200	54	)	)	PUNCT
admet-544	200	55	.	.	PUNCT
admet-544	201	1	cp	cp	PROPN
admet-544	201	2	stands	stand	VERB
admet-544	201	3	for	for	ADP
admet-544	201	4	the	the	DET
admet-544	201	5	natural	natural	ADJ
admet-544	201	6	cyclic	cyclic	ADJ
admet-544	201	7	peptide	peptide	NOUN
admet-544	201	8	drug	drug	NOUN
admet-544	201	9	cyclosporin	cyclosporin	NOUN
admet-544	201	10	.	.	PUNCT
admet-544	202	1	the	the	DET
admet-544	202	2	estimated	estimate	VERB
admet-544	202	3	brain	brain	NOUN
admet-544	202	4	to	to	ADP
admet-544	202	5	blood	blood	NOUN
admet-544	202	6	ratio	ratio	NOUN
admet-544	202	7	(	(	PUNCT
admet-544	202	8	log	log	NOUN
admet-544	202	9	k	k	PROPN
admet-544	202	10	bb	bb	PROPN
admet-544	202	11	)	)	PUNCT
admet-544	202	12	and	and	CCONJ
admet-544	202	13	cell	cell	NOUN
admet-544	202	14	partition	partition	NOUN
admet-544	202	15	(	(	PUNCT
admet-544	202	16	log	log	NOUN
admet-544	202	17	kpcell	kpcell	ADJ
admet-544	202	18	)	)	PUNCT
admet-544	202	19	have	have	AUX
admet-544	202	20	been	be	AUX
admet-544	202	21	also	also	ADV
admet-544	202	22	compared	compare	VERB
admet-544	202	23	based	base	VERB
admet-544	202	24	on	on	ADP
admet-544	202	25	the	the	DET
admet-544	202	26	measured	measure	VERB
admet-544	202	27	hplc	hplc	NOUN
admet-544	202	28	based	base	VERB
admet-544	202	29	biomimetic	biomimetic	ADJ
admet-544	202	30	properties	property	NOUN
admet-544	202	31	for	for	ADP
admet-544	202	32	the	the	DET
admet-544	202	33	peptides	peptide	NOUN
admet-544	202	34	,	,	PUNCT
admet-544	202	35	for	for	ADP
admet-544	202	36	the	the	DET
admet-544	202	37	known	know	VERB
admet-544	202	38	drugs	drug	NOUN
admet-544	202	39	and	and	CCONJ
admet-544	202	40	for	for	ADP
admet-544	202	41	the	the	DET
admet-544	202	42	macrolides	macrolide	NOUN
admet-544	202	43	as	as	SCONJ
admet-544	202	44	shown	show	VERB
admet-544	202	45	in	in	ADP
admet-544	202	46	figure	figure	NOUN
admet-544	202	47	7	7	NUM
admet-544	202	48	.	.	PUNCT
admet-544	202	49	a	a	DET
admet-544	202	50	)	)	PUNCT
admet-544	202	51	b	b	NOUN
admet-544	202	52	)	)	PUNCT
admet-544	202	53	figure	figure	NOUN
admet-544	202	54	7	7	NUM
admet-544	202	55	.	.	PUNCT
admet-544	203	1	distribution	distribution	NOUN
admet-544	203	2	of	of	ADP
admet-544	203	3	the	the	DET
admet-544	203	4	estimated	estimate	VERB
admet-544	203	5	brain	brain	NOUN
admet-544	203	6	to	to	ADP
admet-544	203	7	blood	blood	NOUN
admet-544	203	8	ratio	ratio	NOUN
admet-544	203	9	(	(	PUNCT
admet-544	203	10	log	log	NOUN
admet-544	203	11	k	k	PROPN
admet-544	203	12	bb	bb	PROPN
admet-544	203	13	)	)	PUNCT
admet-544	203	14	(	(	PUNCT
admet-544	203	15	a	a	NOUN
admet-544	203	16	)	)	PUNCT
admet-544	203	17	and	and	CCONJ
admet-544	203	18	cell	cell	NOUN
admet-544	203	19	partition	partition	NOUN
admet-544	203	20	(	(	PUNCT
admet-544	203	21	kpcell	kpcell	ADJ
admet-544	203	22	)	)	PUNCT
admet-544	203	23	(	(	PUNCT
admet-544	203	24	b	b	NOUN
admet-544	203	25	)	)	PUNCT
admet-544	203	26	,	,	PUNCT
admet-544	203	27	for	for	ADP
admet-544	203	28	the	the	DET
admet-544	203	29	peptides	peptide	NOUN
admet-544	203	30	in	in	ADP
admet-544	203	31	comparison	comparison	NOUN
admet-544	203	32	to	to	ADP
admet-544	203	33	macrocycle	macrocycle	NOUN
admet-544	203	34	(	(	PUNCT
admet-544	203	35	mc	mc	PROPN
admet-544	203	36	)	)	PUNCT
admet-544	203	37	,	,	PUNCT
admet-544	203	38	small	small	ADJ
admet-544	203	39	molecule	molecule	NOUN
admet-544	203	40	drugs	drug	NOUN
admet-544	203	41	(	(	PUNCT
admet-544	203	42	drug	drug	NOUN
admet-544	203	43	)	)	PUNCT
admet-544	203	44	,	,	PUNCT
admet-544	203	45	inhaled	inhale	VERB
admet-544	203	46	drugs	drug	NOUN
admet-544	203	47	and	and	CCONJ
admet-544	203	48	drugs	drug	NOUN
admet-544	203	49	that	that	PRON
admet-544	203	50	can	can	AUX
admet-544	203	51	go	go	VERB
admet-544	203	52	to	to	ADP
admet-544	203	53	the	the	DET
admet-544	203	54	central	central	ADJ
admet-544	203	55	nervous	nervous	ADJ
admet-544	203	56	system	system	NOUN
admet-544	203	57	(	(	PUNCT
admet-544	203	58	cns	cns	NOUN
admet-544	203	59	)	)	PUNCT
admet-544	203	60	.	.	PUNCT
admet-544	204	1	cp	cp	PROPN
admet-544	204	2	stands	stand	VERB
admet-544	204	3	for	for	ADP
admet-544	204	4	the	the	DET
admet-544	204	5	natural	natural	ADJ
admet-544	204	6	cyclic	cyclic	ADJ
admet-544	204	7	peptide	peptide	NOUN
admet-544	204	8	drug	drug	NOUN
admet-544	204	9	cyclosporin	cyclosporin	NOUN
admet-544	204	10	.	.	PUNCT
admet-544	205	1	(	(	PUNCT
admet-544	205	2	the	the	DET
admet-544	205	3	macrocycles	macrocycle	NOUN
admet-544	205	4	(	(	PUNCT
admet-544	205	5	mc	mc	PROPN
admet-544	205	6	)	)	PUNCT
admet-544	205	7	did	do	AUX
admet-544	205	8	not	not	PART
admet-544	205	9	have	have	VERB
admet-544	205	10	all	all	DET
admet-544	205	11	the	the	DET
admet-544	205	12	data	datum	NOUN
admet-544	205	13	for	for	ADP
admet-544	205	14	estimating	estimate	VERB
admet-544	205	15	the	the	DET
admet-544	205	16	log	log	NOUN
admet-544	206	1	k	k	PROPN
admet-544	206	2	bb	bb	INTJ
admet-544	206	3	therefore	therefore	ADV
admet-544	206	4	they	they	PRON
admet-544	206	5	are	be	AUX
admet-544	206	6	not	not	PART
admet-544	206	7	shown	show	VERB
admet-544	206	8	in	in	ADP
admet-544	206	9	(	(	PUNCT
admet-544	206	10	a	a	X
admet-544	206	11	)	)	PUNCT
admet-544	206	12	the	the	DET
admet-544	206	13	interrelationship	interrelationship	NOUN
admet-544	206	14	between	between	ADP
admet-544	206	15	the	the	DET
admet-544	206	16	measured	measure	VERB
admet-544	206	17	lipophilicity	lipophilicity	NOUN
admet-544	206	18	and	and	CCONJ
admet-544	206	19	biomimetic	biomimetic	ADJ
admet-544	206	20	properties	property	NOUN
admet-544	206	21	of	of	ADP
admet-544	206	22	the	the	DET
admet-544	206	23	peptides	peptide	NOUN
admet-544	206	24	have	have	AUX
admet-544	206	25	been	be	AUX
admet-544	206	26	investigated	investigate	VERB
admet-544	206	27	and	and	CCONJ
admet-544	206	28	a	a	DET
admet-544	206	29	comparison	comparison	NOUN
admet-544	206	30	made	make	VERB
admet-544	206	31	to	to	ADP
admet-544	206	32	the	the	DET
admet-544	206	33	marketed	market	VERB
admet-544	206	34	drugs	drug	NOUN
admet-544	206	35	.	.	PUNCT
admet-544	207	1	in	in	ADP
admet-544	207	2	every	every	DET
admet-544	207	3	respect	respect	NOUN
admet-544	207	4	,	,	PUNCT
admet-544	207	5	very	very	ADV
admet-544	207	6	similar	similar	ADJ
admet-544	207	7	relationships	relationship	NOUN
admet-544	207	8	were	be	AUX
admet-544	207	9	observed	observe	VERB
admet-544	207	10	.	.	PUNCT
admet-544	208	1	figure	figure	NOUN
admet-544	208	2	8	8	NUM
admet-544	208	3	shows	show	VERB
admet-544	208	4	a	a	DET
admet-544	208	5	good	good	ADJ
admet-544	208	6	trend	trend	NOUN
admet-544	208	7	between	between	ADP
admet-544	208	8	the	the	DET
admet-544	208	9	agp	agp	PROPN
admet-544	208	10	and	and	CCONJ
admet-544	208	11	iam	iam	PROPN
admet-544	208	12	binding	bind	VERB
admet-544	208	13	of	of	ADP
admet-544	208	14	the	the	DET
admet-544	208	15	compounds	compound	NOUN
admet-544	208	16	,	,	PUNCT
admet-544	208	17	as	as	SCONJ
admet-544	208	18	both	both	DET
admet-544	208	19	bindings	binding	NOUN
admet-544	208	20	are	be	AUX
admet-544	208	21	influenced	influence	VERB
admet-544	208	22	by	by	ADP
admet-544	208	23	the	the	DET
admet-544	208	24	presence	presence	NOUN
admet-544	208	25	of	of	ADP
admet-544	208	26	the	the	DET
admet-544	208	27	positive	positive	ADJ
admet-544	208	28	charge	charge	NOUN
admet-544	208	29	and	and	CCONJ
admet-544	208	30	general	general	ADJ
admet-544	208	31	lipophilicity	lipophilicity	NOUN
admet-544	208	32	of	of	ADP
admet-544	208	33	the	the	DET
admet-544	208	34	compounds	compound	NOUN
admet-544	208	35	.	.	PUNCT
admet-544	209	1	both	both	CCONJ
admet-544	209	2	the	the	DET
admet-544	209	3	linear	linear	NOUN
admet-544	209	4	and	and	CCONJ
admet-544	209	5	the	the	DET
admet-544	209	6	cyclic	cyclic	ADJ
admet-544	209	7	peptides	peptide	NOUN
admet-544	209	8	follow	follow	VERB
admet-544	209	9	the	the	DET
admet-544	209	10	same	same	ADJ
admet-544	209	11	trend	trend	NOUN
admet-544	209	12	as	as	ADP
admet-544	209	13	the	the	DET
admet-544	209	14	marketed	market	VERB
admet-544	209	15	drugs	drug	NOUN
admet-544	209	16	and	and	CCONJ
admet-544	209	17	macrolides	macrolide	NOUN
admet-544	209	18	.	.	PUNCT
admet-544	210	1	one	one	NUM
admet-544	210	2	of	of	ADP
admet-544	210	3	the	the	DET
admet-544	210	4	investigated	investigate	VERB
admet-544	210	5	compounds	compound	NOUN
admet-544	210	6	,	,	PUNCT
admet-544	210	7	genervon	genervon	PROPN
admet-544	210	8	’s	’s	PART
admet-544	210	9	gm6	gm6	PROPN
admet-544	210	10	has	have	AUX
admet-544	210	11	been	be	AUX
admet-544	210	12	evaluated	evaluate	VERB
admet-544	210	13	in	in	ADP
admet-544	210	14	vivo	vivo	NOUN
admet-544	210	15	in	in	ADP
admet-544	210	16	a	a	DET
admet-544	210	17	mouse	mouse	NOUN
admet-544	210	18	model	model	NOUN
admet-544	210	19	and	and	CCONJ
admet-544	210	20	also	also	ADV
admet-544	210	21	in	in	ADP
admet-544	210	22	humans	human	NOUN
admet-544	210	23	.	.	PUNCT
admet-544	211	1	it	it	PRON
admet-544	211	2	has	have	AUX
admet-544	211	3	shown	show	VERB
admet-544	211	4	an	an	DET
admet-544	211	5	effect	effect	NOUN
admet-544	211	6	in	in	ADP
admet-544	211	7	the	the	DET
admet-544	211	8	sod1	sod1	ADJ
admet-544	211	9	mouse	mouse	NOUN
admet-544	211	10	model	model	NOUN
admet-544	211	11	for	for	ADP
admet-544	211	12	als	al	NOUN
admet-544	211	13	and	and	CCONJ
admet-544	211	14	in	in	ADP
admet-544	211	15	als	als	NOUN
admet-544	211	16	patients	patient	NOUN
admet-544	211	17	[	[	X
admet-544	211	18	42	42	NUM
admet-544	211	19	]	]	PUNCT
admet-544	211	20	.	.	PUNCT
admet-544	212	1	as	as	SCONJ
admet-544	212	2	predicted	predict	VERB
admet-544	212	3	,	,	PUNCT
admet-544	212	4	the	the	DET
admet-544	212	5	peptide	peptide	NOUN
admet-544	212	6	has	have	AUX
admet-544	212	7	been	be	AUX
admet-544	212	8	detected	detect	VERB
admet-544	212	9	in	in	ADP
admet-544	212	10	the	the	DET
admet-544	212	11	cells	cell	NOUN
admet-544	212	12	,	,	PUNCT
admet-544	212	13	especially	especially	ADV
admet-544	212	14	in	in	ADP
admet-544	212	15	the	the	DET
admet-544	212	16	motoneuron	motoneuron	NOUN
admet-544	212	17	cells	cell	NOUN
admet-544	212	18	and	and	CCONJ
admet-544	212	19	was	be	AUX
admet-544	212	20	strongly	strongly	ADV
admet-544	212	21	associated	associate	VERB
admet-544	212	22	with	with	ADP
admet-544	212	23	the	the	DET
admet-544	212	24	cell	cell	NOUN
admet-544	212	25	membrane	membrane	NOUN
admet-544	212	26	as	as	SCONJ
admet-544	212	27	confirmed	confirm	VERB
admet-544	212	28	using	use	VERB
admet-544	212	29	immune	immune	ADJ
admet-544	212	30	imaging	imaging	NOUN
admet-544	212	31	technology	technology	NOUN
admet-544	212	32	.	.	PUNCT
admet-544	213	1	gm6	gm6	PROPN
admet-544	213	2	(	(	PUNCT
admet-544	213	3	lp4	lp4	PROPN
admet-544	213	4	)	)	PUNCT
admet-544	213	5	has	have	AUX
admet-544	213	6	also	also	ADV
admet-544	213	7	been	be	AUX
admet-544	213	8	detected	detect	VERB
admet-544	213	9	in	in	ADP
admet-544	213	10	the	the	DET
admet-544	213	11	cerebrospinal	cerebrospinal	ADJ
admet-544	213	12	fluid	fluid	NOUN
admet-544	213	13	in	in	ADP
admet-544	213	14	mice	mouse	NOUN
admet-544	213	15	after	after	ADP
admet-544	213	16	4	4	NUM
admet-544	213	17	hours	hour	NOUN
admet-544	213	18	.	.	PUNCT
admet-544	214	1	these	these	DET
admet-544	214	2	preliminary	preliminary	ADJ
admet-544	214	3	results	result	NOUN
admet-544	214	4	encourage	encourage	VERB
admet-544	214	5	further	further	ADJ
admet-544	214	6	studies	study	NOUN
admet-544	214	7	of	of	ADP
admet-544	214	8	new	new	ADJ
admet-544	214	9	modalities	modality	NOUN
admet-544	214	10	,	,	PUNCT
admet-544	214	11	such	such	ADJ
admet-544	214	12	as	as	ADP
admet-544	214	13	peptides	peptide	NOUN
admet-544	214	14	,	,	PUNCT
admet-544	214	15	cyclic	cyclic	ADJ
admet-544	214	16	peptides	peptide	NOUN
admet-544	214	17	and	and	CCONJ
admet-544	214	18	macrocycles	macrocycle	NOUN
admet-544	214	19	using	use	VERB
admet-544	214	20	biomimetic	biomimetic	ADJ
admet-544	214	21	chromatographic	chromatographic	ADJ
admet-544	214	22	methods	method	NOUN
admet-544	214	23	and	and	CCONJ
admet-544	214	24	models	model	NOUN
admet-544	214	25	.	.	PUNCT
admet-544	215	1	admet	admet	PROPN
admet-544	215	2	&	&	CCONJ
admet-544	215	3	dmpk	dmpk	PROPN
admet-544	215	4	6(2	6(2	NUM
admet-544	215	5	)	)	PUNCT
admet-544	215	6	(	(	PUNCT
admet-544	215	7	2018	2018	NUM
admet-544	215	8	)	)	PUNCT
admet-544	215	9	162	162	NUM
admet-544	215	10	-	-	SYM
admet-544	215	11	175	175	NUM
admet-544	215	12	biomimetic	biomimetic	ADJ
admet-544	215	13	hplc	hplc	NOUN
admet-544	215	14	in	in	ADP
admet-544	215	15	the	the	DET
admet-544	215	16	estimation	estimation	NOUN
admet-544	215	17	of	of	ADP
admet-544	215	18	physchem	physchem	NOUN
admet-544	215	19	properties	property	NOUN
admet-544	215	20	of	of	ADP
admet-544	215	21	peptides	peptide	NOUN
admet-544	215	22	doi	doi	NOUN
admet-544	215	23	:	:	PUNCT
admet-544	215	24	10.5599	10.5599	NUM
admet-544	215	25	/	/	SYM
admet-544	215	26	admet.544	admet.544	PROPN
admet-544	215	27	173	173	NUM
admet-544	215	28	figure	figure	NOUN
admet-544	215	29	8	8	NUM
admet-544	215	30	.	.	PUNCT
admet-544	216	1	the	the	DET
admet-544	216	2	trend	trend	NOUN
admet-544	216	3	between	between	ADP
admet-544	216	4	the	the	DET
admet-544	216	5	alpha-1	alpha-1	NOUN
admet-544	216	6	-	-	PUNCT
admet-544	216	7	acid	acid	NOUN
admet-544	216	8	glycoprotein	glycoprotein	NOUN
admet-544	216	9	binding	bind	VERB
admet-544	216	10	(	(	PUNCT
admet-544	216	11	log	log	NOUN
admet-544	216	12	k	k	PROPN
admet-544	216	13	agp	agp	PROPN
admet-544	216	14	)	)	PUNCT
admet-544	216	15	and	and	CCONJ
admet-544	216	16	phospholipid	phospholipid	NOUN
admet-544	216	17	binding	bind	VERB
admet-544	216	18	(	(	PUNCT
admet-544	216	19	log	log	PROPN
admet-544	216	20	k	k	PROPN
admet-544	216	21	iam	iam	PROPN
admet-544	216	22	)	)	PUNCT
admet-544	216	23	for	for	ADP
admet-544	216	24	peptides	peptide	NOUN
admet-544	216	25	,	,	PUNCT
admet-544	216	26	marketed	market	VERB
admet-544	216	27	drugs	drug	NOUN
admet-544	216	28	and	and	CCONJ
admet-544	216	29	macrolides	macrolide	NOUN
admet-544	216	30	.	.	PUNCT
admet-544	217	1	(	(	PUNCT
admet-544	217	2	colour	colour	NOUN
admet-544	217	3	code	code	NOUN
admet-544	217	4	is	be	AUX
admet-544	217	5	the	the	DET
admet-544	217	6	same	same	ADJ
admet-544	217	7	as	as	ADP
admet-544	217	8	in	in	ADP
admet-544	217	9	figure	figure	NOUN
admet-544	217	10	6	6	NUM
admet-544	217	11	and	and	CCONJ
admet-544	217	12	7	7	NUM
admet-544	217	13	.	.	PUNCT
admet-544	218	1	conclusions	conclusion	NOUN
admet-544	218	2	the	the	DET
admet-544	218	3	hplc	hplc	NOUN
admet-544	218	4	based	base	VERB
admet-544	218	5	physicochemical	physicochemical	ADJ
admet-544	218	6	and	and	CCONJ
admet-544	218	7	biomimetic	biomimetic	ADJ
admet-544	218	8	property	property	NOUN
admet-544	218	9	measurements	measurement	NOUN
admet-544	218	10	have	have	AUX
admet-544	218	11	been	be	AUX
admet-544	218	12	carried	carry	VERB
admet-544	218	13	out	out	ADP
admet-544	218	14	on	on	ADP
admet-544	218	15	linear	linear	ADJ
admet-544	218	16	and	and	CCONJ
admet-544	218	17	bicyclic	bicyclic	ADJ
admet-544	218	18	peptides	peptide	NOUN
admet-544	218	19	.	.	PUNCT
admet-544	219	1	the	the	DET
admet-544	219	2	measured	measure	VERB
admet-544	219	3	properties	property	NOUN
admet-544	219	4	,	,	PUNCT
admet-544	219	5	such	such	ADJ
admet-544	219	6	as	as	ADP
admet-544	219	7	lipophilicity	lipophilicity	NOUN
admet-544	219	8	expressed	express	VERB
admet-544	219	9	as	as	ADP
admet-544	219	10	chi	chi	PROPN
admet-544	219	11	log	log	PROPN
admet-544	219	12	d	d	PROPN
admet-544	219	13	,	,	PUNCT
admet-544	219	14	phospholipid	phospholipid	NOUN
admet-544	219	15	binding	binding	NOUN
admet-544	219	16	expressed	express	VERB
admet-544	219	17	as	as	ADP
admet-544	219	18	chi	chi	PROPN
admet-544	219	19	iam	iam	PROPN
admet-544	219	20	(	(	PUNCT
admet-544	219	21	log	log	PROPN
admet-544	219	22	k	k	PROPN
admet-544	219	23	iam	iam	PROPN
admet-544	219	24	)	)	PUNCT
admet-544	219	25	and	and	CCONJ
admet-544	219	26	protein	protein	NOUN
admet-544	219	27	binding	bind	VERB
admet-544	219	28	(	(	PUNCT
admet-544	219	29	%	%	INTJ
admet-544	219	30	hsa	hsa	NOUN
admet-544	219	31	and	and	CCONJ
admet-544	219	32	%	%	INTJ
admet-544	219	33	agp	agp	PROPN
admet-544	219	34	)	)	PUNCT
admet-544	219	35	of	of	ADP
admet-544	219	36	selected	select	VERB
admet-544	219	37	linear	linear	NOUN
admet-544	219	38	and	and	CCONJ
admet-544	219	39	bicyclic	bicyclic	ADJ
admet-544	219	40	peptides	peptide	NOUN
admet-544	219	41	have	have	AUX
admet-544	219	42	been	be	AUX
admet-544	219	43	compared	compare	VERB
admet-544	219	44	to	to	ADP
admet-544	219	45	the	the	DET
admet-544	219	46	similar	similar	ADJ
admet-544	219	47	measured	measured	ADJ
admet-544	219	48	properties	property	NOUN
admet-544	219	49	of	of	ADP
admet-544	219	50	marketed	market	VERB
admet-544	219	51	drugs	drug	NOUN
admet-544	219	52	.	.	PUNCT
admet-544	220	1	the	the	DET
admet-544	220	2	lipophilicity	lipophilicity	NOUN
admet-544	220	3	,	,	PUNCT
admet-544	220	4	phospholipid	phospholipid	NOUN
admet-544	220	5	binding	bind	VERB
admet-544	220	6	and	and	CCONJ
admet-544	220	7	protein	protein	NOUN
admet-544	220	8	binding	bind	VERB
admet-544	220	9	have	have	AUX
admet-544	220	10	been	be	AUX
admet-544	220	11	compared	compare	VERB
admet-544	220	12	to	to	ADP
admet-544	220	13	the	the	DET
admet-544	220	14	molecular	molecular	ADJ
admet-544	220	15	weight	weight	NOUN
admet-544	220	16	of	of	ADP
admet-544	220	17	the	the	DET
admet-544	220	18	peptides	peptide	NOUN
admet-544	220	19	.	.	PUNCT
admet-544	221	1	it	it	PRON
admet-544	221	2	was	be	AUX
admet-544	221	3	found	find	VERB
admet-544	221	4	that	that	SCONJ
admet-544	221	5	larger	large	ADJ
admet-544	221	6	molecular	molecular	ADJ
admet-544	221	7	weight	weight	NOUN
admet-544	221	8	peptides	peptide	NOUN
admet-544	221	9	had	have	VERB
admet-544	221	10	greater	great	ADJ
admet-544	221	11	lipophilicity	lipophilicity	NOUN
admet-544	221	12	,	,	PUNCT
admet-544	221	13	phospholipid	phospholipid	NOUN
admet-544	221	14	and	and	CCONJ
admet-544	221	15	protein	protein	NOUN
admet-544	221	16	binding	binding	NOUN
admet-544	221	17	;	;	PUNCT
admet-544	221	18	however	however	ADV
admet-544	221	19	,	,	PUNCT
admet-544	221	20	the	the	DET
admet-544	221	21	trend	trend	NOUN
admet-544	221	22	was	be	AUX
admet-544	221	23	broken	break	VERB
admet-544	221	24	for	for	ADP
admet-544	221	25	bicyclic	bicyclic	ADJ
admet-544	221	26	peptides	peptide	NOUN
admet-544	221	27	and	and	CCONJ
admet-544	221	28	linear	linear	ADJ
admet-544	221	29	peptides	peptide	NOUN
admet-544	221	30	above	above	ADP
admet-544	221	31	16	16	NUM
admet-544	221	32	amino	amino	NOUN
admet-544	221	33	acids	acid	NOUN
admet-544	221	34	.	.	PUNCT
admet-544	222	1	it	it	PRON
admet-544	222	2	suggests	suggest	VERB
admet-544	222	3	that	that	SCONJ
admet-544	222	4	the	the	DET
admet-544	222	5	effect	effect	NOUN
admet-544	222	6	of	of	ADP
admet-544	222	7	the	the	DET
admet-544	222	8	amino	amino	NOUN
admet-544	222	9	acids	acid	NOUN
admet-544	222	10	on	on	ADP
admet-544	222	11	the	the	DET
admet-544	222	12	interactions	interaction	NOUN
admet-544	222	13	with	with	ADP
admet-544	222	14	lipids	lipid	NOUN
admet-544	222	15	and	and	CCONJ
admet-544	222	16	proteins	protein	NOUN
admet-544	222	17	are	be	AUX
admet-544	222	18	shielded	shield	VERB
admet-544	222	19	for	for	ADP
admet-544	222	20	larger	large	ADJ
admet-544	222	21	or	or	CCONJ
admet-544	222	22	cyclic	cyclic	ADJ
admet-544	222	23	peptides	peptide	NOUN
admet-544	222	24	.	.	PUNCT
admet-544	223	1	the	the	DET
admet-544	223	2	in	in	ADP
admet-544	223	3	vivo	vivo	ADJ
admet-544	223	4	distribution	distribution	NOUN
admet-544	223	5	models	model	NOUN
admet-544	223	6	developed	develop	VERB
admet-544	223	7	for	for	ADP
admet-544	223	8	small	small	ADJ
admet-544	223	9	molecules	molecule	NOUN
admet-544	223	10	have	have	AUX
admet-544	223	11	been	be	AUX
admet-544	223	12	applied	apply	VERB
admet-544	223	13	for	for	ADP
admet-544	223	14	the	the	DET
admet-544	223	15	first	first	ADJ
admet-544	223	16	time	time	NOUN
admet-544	223	17	to	to	ADP
admet-544	223	18	peptides	peptide	NOUN
admet-544	223	19	.	.	PUNCT
admet-544	224	1	the	the	DET
admet-544	224	2	estimation	estimation	NOUN
admet-544	224	3	of	of	ADP
admet-544	224	4	good	good	ADJ
admet-544	224	5	cell	cell	NOUN
admet-544	224	6	and	and	CCONJ
admet-544	224	7	brain	brain	NOUN
admet-544	224	8	penetration	penetration	NOUN
admet-544	224	9	for	for	ADP
admet-544	224	10	lp4	lp4	PROPN
admet-544	224	11	(	(	PUNCT
admet-544	224	12	gm6	gm6	PROPN
admet-544	224	13	)	)	PUNCT
admet-544	224	14	,	,	PUNCT
admet-544	224	15	a	a	DET
admet-544	224	16	linear	linear	ADJ
admet-544	224	17	peptide	peptide	NOUN
admet-544	224	18	with	with	ADP
admet-544	224	19	6	6	NUM
admet-544	224	20	amino	amino	NOUN
admet-544	224	21	acids	acid	NOUN
admet-544	224	22	,	,	PUNCT
admet-544	224	23	has	have	AUX
admet-544	224	24	been	be	AUX
admet-544	224	25	validated	validate	VERB
admet-544	224	26	in	in	ADP
admet-544	224	27	in	in	ADP
admet-544	224	28	vitro	vitro	X
admet-544	224	29	assays	assay	NOUN
admet-544	224	30	.	.	PUNCT
admet-544	225	1	biomimetic	biomimetic	ADJ
admet-544	225	2	hplc	hplc	NOUN
admet-544	225	3	measurements	measurement	NOUN
admet-544	225	4	can	can	AUX
admet-544	225	5	,	,	PUNCT
admet-544	225	6	therefore	therefore	ADV
admet-544	225	7	,	,	PUNCT
admet-544	225	8	contribute	contribute	VERB
admet-544	225	9	to	to	ADP
admet-544	225	10	the	the	DET
admet-544	225	11	design	design	NOUN
admet-544	225	12	of	of	ADP
admet-544	225	13	peptide	peptide	ADJ
admet-544	225	14	therapeutics	therapeutic	NOUN
admet-544	225	15	with	with	ADP
admet-544	225	16	good	good	ADJ
admet-544	225	17	drug	drug	NOUN
admet-544	225	18	-	-	PUNCT
admet-544	225	19	like	like	ADJ
admet-544	225	20	properties	property	NOUN
admet-544	225	21	.	.	PUNCT
admet-544	226	1	references	reference	NOUN
admet-544	226	2	[	[	X
admet-544	226	3	1	1	NUM
admet-544	226	4	]	]	X
admet-544	226	5	a.a	a.a	PROPN
admet-544	226	6	.	.	PROPN
admet-544	226	7	kaspar	kaspar	PROPN
admet-544	226	8	,	,	PUNCT
admet-544	226	9	j.m	j.m	PROPN
admet-544	226	10	.	.	PROPN
admet-544	226	11	reichert	reichert	PROPN
admet-544	226	12	.	.	PUNCT
admet-544	227	1	future	future	ADJ
admet-544	227	2	directions	direction	NOUN
admet-544	227	3	for	for	ADP
admet-544	227	4	peptide	peptide	ADJ
admet-544	227	5	therapeutics	therapeutic	NOUN
admet-544	227	6	development	development	NOUN
admet-544	227	7	.	.	PUNCT
admet-544	228	1	drug	drug	NOUN
admet-544	228	2	discov	discov	NOUN
admet-544	228	3	.	.	PUNCT
admet-544	229	1	today	today	NOUN
admet-544	229	2	18	18	NUM
admet-544	229	3	(	(	PUNCT
admet-544	229	4	2013	2013	NUM
admet-544	229	5	)	)	PUNCT
admet-544	229	6	807–817	807–817	NUM
admet-544	229	7	.	.	PUNCT
admet-544	230	1	[	[	X
admet-544	230	2	2	2	NUM
admet-544	230	3	]	]	PUNCT
admet-544	230	4	k.	k.	NOUN
admet-544	230	5	fosgerau	fosgerau	PROPN
admet-544	230	6	,	,	PUNCT
admet-544	230	7	t.	t.	PROPN
admet-544	230	8	hoffmann	hoffmann	PROPN
admet-544	230	9	.	.	PUNCT
admet-544	231	1	peptide	peptide	NOUN
admet-544	231	2	therapeutics	therapeutic	NOUN
admet-544	231	3	:	:	PUNCT
admet-544	231	4	current	current	ADJ
admet-544	231	5	status	status	NOUN
admet-544	231	6	and	and	CCONJ
admet-544	231	7	future	future	ADJ
admet-544	231	8	directions	direction	NOUN
admet-544	231	9	.	.	PUNCT
admet-544	232	1	drug	drug	NOUN
admet-544	232	2	discov	discov	NOUN
admet-544	232	3	.	.	PUNCT
admet-544	233	1	today	today	NOUN
admet-544	233	2	20	20	NUM
admet-544	233	3	(	(	PUNCT
admet-544	233	4	2015	2015	NUM
admet-544	233	5	)	)	PUNCT
admet-544	233	6	122–128	122–128	NUM
admet-544	233	7	.	.	PUNCT
admet-544	234	1	[	[	X
admet-544	234	2	3	3	X
admet-544	234	3	]	]	X
admet-544	234	4	c.a	c.a	PROPN
admet-544	234	5	.	.	PROPN
admet-544	234	6	lipinski	lipinski	PROPN
admet-544	234	7	,	,	PUNCT
admet-544	234	8	f.	f.	PROPN
admet-544	234	9	lombardo	lombardo	PROPN
admet-544	234	10	,	,	PUNCT
admet-544	234	11	b.w	b.w	PROPN
admet-544	234	12	.	.	PROPN
admet-544	234	13	dominy	dominy	PROPN
admet-544	234	14	,	,	PUNCT
admet-544	234	15	p.j	p.j	PROPN
admet-544	234	16	.	.	PROPN
admet-544	234	17	feeney	feeney	PROPN
admet-544	234	18	.	.	PUNCT
admet-544	235	1	experimental	experimental	ADJ
admet-544	235	2	and	and	CCONJ
admet-544	235	3	computational	computational	ADJ
admet-544	235	4	approaches	approach	NOUN
admet-544	235	5	to	to	PART
admet-544	235	6	estimate	estimate	VERB
admet-544	235	7	solubility	solubility	NOUN
admet-544	235	8	and	and	CCONJ
admet-544	235	9	permeability	permeability	NOUN
admet-544	235	10	in	in	ADP
admet-544	235	11	drug	drug	NOUN
admet-544	235	12	discovery	discovery	NOUN
admet-544	235	13	and	and	CCONJ
admet-544	235	14	develop	develop	VERB
admet-544	235	15	ment	ment	ADJ
admet-544	235	16	settings	setting	NOUN
admet-544	235	17	.	.	PUNCT
admet-544	236	1	adv	adv	PROPN
admet-544	236	2	.	.	PUNCT
admet-544	236	3	drug	drug	PROPN
admet-544	236	4	deliv	deliv	PROPN
admet-544	236	5	.	.	PUNCT
admet-544	237	1	rev	rev	PROPN
admet-544	237	2	.	.	PROPN
admet-544	237	3	23	23	NUM
admet-544	237	4	(	(	PUNCT
admet-544	237	5	1997	1997	NUM
admet-544	237	6	)	)	PUNCT
admet-544	238	1	3–25	3–25	VERB
admet-544	238	2	.	.	PUNCT
admet-544	239	1	[	[	X
admet-544	239	2	4	4	NUM
admet-544	239	3	]	]	X
admet-544	239	4	l.t	l.t	PROPN
admet-544	239	5	.	.	PROPN
admet-544	239	6	nguyen	nguyen	PROPN
admet-544	239	7	,	,	PUNCT
admet-544	239	8	j.k	j.k	PROPN
admet-544	239	9	.	.	PROPN
admet-544	239	10	chau	chau	PROPN
admet-544	239	11	,	,	PUNCT
admet-544	239	12	n.a	n.a	PROPN
admet-544	239	13	.	.	PROPN
admet-544	239	14	perry	perry	PROPN
admet-544	239	15	,	,	PUNCT
admet-544	239	16	l.	l.	PROPN
admet-544	239	17	de	de	PROPN
admet-544	239	18	boer	boer	PROPN
admet-544	239	19	,	,	PUNCT
admet-544	239	20	s.a.j	s.a.j	ADJ
admet-544	239	21	.	.	PUNCT
admet-544	240	1	zaat	zaat	PROPN
admet-544	240	2	,	,	PUNCT
admet-544	240	3	h.j	h.j	PROPN
admet-544	240	4	.	.	PROPN
admet-544	240	5	vogel	vogel	PROPN
admet-544	240	6	.	.	PUNCT
admet-544	241	1	serum	serum	NOUN
admet-544	241	2	stabilities	stability	NOUN
admet-544	241	3	of	of	ADP
admet-544	241	4	short	short	ADJ
admet-544	241	5	tryptophanand	tryptophanand	NOUN
admet-544	241	6	arginine	arginine	NOUN
admet-544	241	7	-	-	PUNCT
admet-544	241	8	rich	rich	ADJ
admet-544	241	9	antimicrobial	antimicrobial	ADJ
admet-544	241	10	peptide	peptide	NOUN
admet-544	241	11	analogs	analog	NOUN
admet-544	241	12	.	.	PUNCT
admet-544	242	1	plos	plos	PROPN
admet-544	242	2	one	one	NUM
admet-544	242	3	5	5	NUM
admet-544	242	4	(	(	PUNCT
admet-544	242	5	2010	2010	NUM
admet-544	242	6	)	)	PUNCT
admet-544	242	7	1–8	1–8	X
admet-544	242	8	.	.	PUNCT
admet-544	243	1	[	[	X
admet-544	243	2	5	5	NUM
admet-544	243	3	]	]	X
admet-544	243	4	j.r	j.r	PROPN
admet-544	243	5	.	.	PROPN
admet-544	243	6	north	north	PROPN
admet-544	243	7	,	,	PUNCT
admet-544	243	8	s.	s.	PROPN
admet-544	243	9	takenaka	takenaka	PROPN
admet-544	243	10	,	,	PUNCT
admet-544	243	11	a.	a.	NOUN
admet-544	243	12	rozek	rozek	NOUN
admet-544	243	13	,	,	PUNCT
admet-544	243	14	a.	a.	NOUN
admet-544	243	15	kielczewska	kielczewska	PROPN
admet-544	243	16	,	,	PUNCT
admet-544	243	17	s.	s.	PROPN
admet-544	243	18	opal	opal	PROPN
admet-544	243	19	,	,	PUNCT
admet-544	243	20	l.a	l.a	PROPN
admet-544	243	21	.	.	PROPN
admet-544	243	22	morici	morici	PROPN
admet-544	243	23	,	,	PUNCT
admet-544	243	24	b.b	b.b	PROPN
admet-544	243	25	.	.	PROPN
admet-544	243	26	finlay	finlay	PROPN
admet-544	243	27	,	,	PUNCT
admet-544	243	28	c.j	c.j	PROPN
admet-544	243	29	.	.	PROPN
admet-544	243	30	schaber	schaber	PROPN
admet-544	243	31	,	,	PUNCT
admet-544	243	32	r.	r.	PROPN
admet-544	243	33	straube	straube	PROPN
admet-544	243	34	,	,	PUNCT
admet-544	243	35	o.	o.	PROPN
admet-544	243	36	donini	donini	PROPN
admet-544	243	37	.	.	PUNCT
admet-544	244	1	a	a	DET
admet-544	244	2	novel	novel	ADJ
admet-544	244	3	approach	approach	NOUN
admet-544	244	4	for	for	ADP
admet-544	244	5	emerging	emerge	VERB
admet-544	244	6	and	and	CCONJ
admet-544	244	7	antibiotic	antibiotic	ADJ
admet-544	244	8	resistant	resistant	ADJ
admet-544	244	9	infections	infection	NOUN
admet-544	244	10	:	:	PUNCT
admet-544	244	11	innate	innate	ADJ
admet-544	244	12	defense	defense	NOUN
admet-544	244	13	regulators	regulator	NOUN
admet-544	244	14	as	as	ADP
admet-544	244	15	an	an	DET
admet-544	244	16	agnostic	agnostic	ADJ
admet-544	244	17	therapy	therapy	NOUN
admet-544	244	18	.	.	PUNCT
admet-544	245	1	j.	j.	PROPN
admet-544	245	2	biotechnol	biotechnol	PROPN
admet-544	245	3	.	.	PUNCT
admet-544	246	1	226	226	NUM
admet-544	246	2	(	(	PUNCT
admet-544	246	3	2016	2016	NUM
admet-544	246	4	)	)	PUNCT
admet-544	246	5	24–34	24–34	NUM
admet-544	246	6	.	.	PUNCT
admet-544	247	1	[	[	X
admet-544	247	2	6	6	NUM
admet-544	247	3	]	]	PUNCT
admet-544	247	4	z.	z.	PROPN
admet-544	247	5	qian	qian	PROPN
admet-544	247	6	,	,	PUNCT
admet-544	247	7	t.	t.	PROPN
admet-544	247	8	liu	liu	PROPN
admet-544	247	9	,	,	PUNCT
admet-544	247	10	y.y	y.y	PROPN
admet-544	247	11	.	.	PROPN
admet-544	247	12	liu	liu	PROPN
admet-544	247	13	,	,	PUNCT
admet-544	247	14	r.	r.	PROPN
admet-544	247	15	briesewitz	briesewitz	PROPN
admet-544	247	16	,	,	PUNCT
admet-544	247	17	a.m.	a.m.	PROPN
admet-544	247	18	barrios	barrios	PROPN
admet-544	247	19	,	,	PUNCT
admet-544	247	20	s.m	s.m	PROPN
admet-544	247	21	.	.	PROPN
admet-544	247	22	jhiang	jhiang	PROPN
admet-544	247	23	,	,	PUNCT
admet-544	247	24	d.	d.	PROPN
admet-544	247	25	pei	pei	PROPN
admet-544	247	26	.	.	PUNCT
admet-544	248	1	efficient	efficient	ADJ
admet-544	248	2	delivery	delivery	NOUN
admet-544	248	3	of	of	ADP
admet-544	248	4	cyclic	cyclic	ADJ
admet-544	248	5	peptides	peptide	NOUN
admet-544	248	6	into	into	ADP
admet-544	248	7	mammalian	mammalian	ADJ
admet-544	248	8	cells	cell	NOUN
admet-544	248	9	with	with	ADP
admet-544	248	10	short	short	ADJ
admet-544	248	11	sequence	sequence	NOUN
admet-544	248	12	motifs	motif	NOUN
admet-544	248	13	.	.	PUNCT
admet-544	249	1	acs	acs	PROPN
admet-544	249	2	chem	chem	NOUN
admet-544	249	3	.	.	PUNCT
admet-544	250	1	biol	biol	PROPN
admet-544	250	2	.	.	PUNCT
admet-544	251	1	8	8	NUM
admet-544	251	2	(	(	PUNCT
admet-544	251	3	2013	2013	NUM
admet-544	251	4	)	)	PUNCT
admet-544	251	5	423–31	423–31	PROPN
admet-544	251	6	.	.	PUNCT
admet-544	252	1	klara	klara	PROPN
admet-544	252	2	valko	valko	PROPN
admet-544	252	3	et	et	PROPN
admet-544	252	4	al	al	PROPN
admet-544	252	5	.	.	PROPN
admet-544	252	6	admet	admet	PROPN
admet-544	252	7	&	&	CCONJ
admet-544	252	8	dmpk	dmpk	PROPN
admet-544	252	9	6(2	6(2	NUM
admet-544	252	10	)	)	PUNCT
admet-544	252	11	(	(	PUNCT
admet-544	252	12	2018	2018	NUM
admet-544	252	13	)	)	PUNCT
admet-544	252	14	162	162	NUM
admet-544	252	15	-	-	SYM
admet-544	252	16	175	175	NUM
admet-544	252	17	174	174	NUM
admet-544	253	1	[	[	X
admet-544	253	2	7	7	X
admet-544	253	3	]	]	PUNCT
admet-544	253	4	v.	v.	ADP
admet-544	253	5	sebbage	sebbage	NOUN
admet-544	253	6	.	.	PUNCT
admet-544	254	1	cell	cell	NOUN
admet-544	254	2	-	-	PUNCT
admet-544	254	3	penetrating	penetrate	VERB
admet-544	254	4	peptides	peptide	NOUN
admet-544	254	5	and	and	CCONJ
admet-544	254	6	their	their	PRON
admet-544	254	7	therapeutic	therapeutic	ADJ
admet-544	254	8	applications	application	NOUN
admet-544	254	9	.	.	PUNCT
admet-544	255	1	biosci	biosci	PROPN
admet-544	255	2	.	.	PUNCT
admet-544	256	1	horizons	horizon	NOUN
admet-544	256	2	,	,	PUNCT
admet-544	256	3	2	2	NUM
admet-544	256	4	(	(	PUNCT
admet-544	256	5	2009	2009	NUM
admet-544	256	6	)	)	PUNCT
admet-544	256	7	64–72	64–72	NOUN
admet-544	256	8	.	.	PUNCT
admet-544	257	1	[	[	X
admet-544	257	2	8	8	NUM
admet-544	257	3	]	]	X
admet-544	257	4	r.	r.	PROPN
admet-544	257	5	trehin	trehin	PROPN
admet-544	257	6	,	,	PUNCT
admet-544	257	7	h.p	h.p	PROPN
admet-544	257	8	.	.	PROPN
admet-544	257	9	merkle	merkle	PROPN
admet-544	257	10	.	.	PUNCT
admet-544	258	1	chances	chance	NOUN
admet-544	258	2	and	and	CCONJ
admet-544	258	3	pitfalls	pitfall	NOUN
admet-544	258	4	of	of	ADP
admet-544	258	5	cell	cell	NOUN
admet-544	258	6	penetrating	penetrate	VERB
admet-544	258	7	peptides	peptide	NOUN
admet-544	258	8	for	for	ADP
admet-544	258	9	cellular	cellular	ADJ
admet-544	258	10	drug	drug	NOUN
admet-544	258	11	delivery	delivery	NOUN
admet-544	258	12	.	.	PUNCT
admet-544	259	1	eur	eur	PROPN
admet-544	259	2	.	.	PUNCT
admet-544	260	1	j.	j.	PROPN
admet-544	260	2	pharm	pharm	PROPN
admet-544	260	3	.	.	PUNCT
admet-544	261	1	biopharm	biopharm	PROPN
admet-544	261	2	.	.	PUNCT
admet-544	262	1	58	58	NUM
admet-544	262	2	(	(	PUNCT
admet-544	262	3	2004	2004	NUM
admet-544	262	4	)	)	PUNCT
admet-544	263	1	209–223	209–223	NUM
admet-544	263	2	.	.	PUNCT
admet-544	264	1	[	[	X
admet-544	264	2	9	9	NUM
admet-544	264	3	]	]	SYM
admet-544	264	4	j.d	j.d	PROPN
admet-544	264	5	.	.	PROPN
admet-544	264	6	ramsey	ramsey	PROPN
admet-544	264	7	,	,	PUNCT
admet-544	264	8	n.h	n.h	PROPN
admet-544	264	9	.	.	PUNCT
admet-544	264	10	flynn	flynn	PROPN
admet-544	264	11	.	.	PUNCT
admet-544	264	12	cell	cell	NOUN
admet-544	264	13	-	-	PUNCT
admet-544	264	14	penetrating	penetrate	VERB
admet-544	264	15	peptides	peptide	NOUN
admet-544	264	16	transport	transport	NOUN
admet-544	264	17	therapeutics	therapeutic	NOUN
admet-544	264	18	into	into	ADP
admet-544	264	19	cells	cell	NOUN
admet-544	264	20	.	.	PUNCT
admet-544	265	1	pharmacol	pharmacol	PROPN
admet-544	265	2	.	.	PUNCT
admet-544	266	1	ther	ther	PROPN
admet-544	266	2	.	.	PUNCT
admet-544	267	1	154	154	NUM
admet-544	267	2	(	(	PUNCT
admet-544	267	3	2015	2015	NUM
admet-544	267	4	)	)	PUNCT
admet-544	267	5	78–86	78–86	NUM
admet-544	267	6	.	.	PUNCT
admet-544	268	1	[	[	X
admet-544	268	2	10	10	NUM
admet-544	268	3	]	]	X
admet-544	268	4	f.	f.	PROPN
admet-544	268	5	wang	wang	PROPN
admet-544	268	6	,	,	PUNCT
admet-544	268	7	y	y	PROPN
admet-544	268	8	wang	wang	PROPN
admet-544	268	9	,	,	PUNCT
admet-544	268	10	x.	x.	PROPN
admet-544	268	11	zhang	zhang	PROPN
admet-544	268	12	,	,	PUNCT
admet-544	268	13	w.	w.	PROPN
admet-544	268	14	zhang	zhang	PROPN
admet-544	268	15	,	,	PUNCT
admet-544	268	16	s.	s.	PROPN
admet-544	268	17	guo	guo	PROPN
admet-544	268	18	,	,	PUNCT
admet-544	268	19	f.	f.	PROPN
admet-544	268	20	jin	jin	PROPN
admet-544	268	21	.	.	PUNCT
admet-544	269	1	recent	recent	ADJ
admet-544	269	2	progress	progress	NOUN
admet-544	269	3	of	of	ADP
admet-544	269	4	cell	cell	NOUN
admet-544	269	5	-	-	PUNCT
admet-544	269	6	penetrating	penetrate	VERB
admet-544	269	7	peptides	peptide	NOUN
admet-544	269	8	as	as	ADP
admet-544	269	9	new	new	ADJ
admet-544	269	10	carriers	carrier	NOUN
admet-544	269	11	for	for	ADP
admet-544	269	12	intracellular	intracellular	ADJ
admet-544	269	13	cargo	cargo	NOUN
admet-544	269	14	delivery	delivery	NOUN
admet-544	269	15	.	.	PUNCT
admet-544	270	1	j.	j.	PROPN
admet-544	270	2	control	control	PROPN
admet-544	270	3	.	.	PUNCT
admet-544	271	1	release	release	VERB
admet-544	271	2	174	174	NUM
admet-544	271	3	(	(	PUNCT
admet-544	271	4	2014	2014	NUM
admet-544	271	5	)	)	PUNCT
admet-544	271	6	78–86	78–86	NUM
admet-544	271	7	.	.	PUNCT
admet-544	272	1	[	[	X
admet-544	272	2	11	11	NUM
admet-544	272	3	]	]	PUNCT
admet-544	272	4	a.	a.	NOUN
admet-544	272	5	gräslund	gräslund	NOUN
admet-544	272	6	,	,	PUNCT
admet-544	272	7	f.	f.	PROPN
admet-544	272	8	madani	madani	PROPN
admet-544	272	9	,	,	PUNCT
admet-544	272	10	s.	s.	PROPN
admet-544	272	11	lindberg	lindberg	PROPN
admet-544	272	12	,	,	PUNCT
admet-544	272	13	ü.	ü.	NOUN
admet-544	272	14	langel	langel	PROPN
admet-544	272	15	,	,	PUNCT
admet-544	272	16	s.	s.	PROPN
admet-544	272	17	futaki	futaki	PROPN
admet-544	272	18	.	.	PUNCT
admet-544	273	1	mechanisms	mechanism	NOUN
admet-544	273	2	of	of	ADP
admet-544	273	3	cellular	cellular	ADJ
admet-544	273	4	uptake	uptake	NOUN
admet-544	273	5	of	of	ADP
admet-544	273	6	cellpenetrating	cellpenetrate	VERB
admet-544	273	7	peptides	peptide	NOUN
admet-544	273	8	.	.	PUNCT
admet-544	274	1	j.	j.	PROPN
admet-544	274	2	biophys	biophys	PROPN
admet-544	274	3	.	.	PUNCT
admet-544	274	4	,	,	PUNCT
admet-544	274	5	2011	2011	NUM
admet-544	274	6	(	(	PUNCT
admet-544	274	7	2011	2011	NUM
admet-544	274	8	)	)	PUNCT
admet-544	274	9	414729	414729	NUM
admet-544	274	10	.	.	PUNCT
admet-544	275	1	[	[	X
admet-544	275	2	12	12	NUM
admet-544	275	3	]	]	X
admet-544	275	4	n.	n.	PROPN
admet-544	275	5	schmidt	schmidt	PROPN
admet-544	275	6	,	,	PUNCT
admet-544	275	7	a.	a.	PROPN
admet-544	275	8	mishra	mishra	PROPN
admet-544	275	9	,	,	PUNCT
admet-544	275	10	g.h	g.h	PROPN
admet-544	275	11	.	.	PROPN
admet-544	275	12	lai	lai	PROPN
admet-544	275	13	,	,	PUNCT
admet-544	275	14	g.c.l	g.c.l	PROPN
admet-544	275	15	.	.	PUNCT
admet-544	276	1	wong	wong	PROPN
admet-544	276	2	.	.	PUNCT
admet-544	276	3	arginine	arginine	PROPN
admet-544	276	4	-	-	PUNCT
admet-544	276	5	rich	rich	ADJ
admet-544	276	6	cell	cell	NOUN
admet-544	276	7	-	-	PUNCT
admet-544	276	8	penetrating	penetrate	VERB
admet-544	276	9	peptides	peptide	NOUN
admet-544	276	10	.	.	PUNCT
admet-544	277	1	febs	febs	PROPN
admet-544	277	2	lett	lett	PROPN
admet-544	277	3	.	.	PUNCT
admet-544	278	1	584	584	NUM
admet-544	278	2	(	(	PUNCT
admet-544	278	3	2010	2010	NUM
admet-544	278	4	)	)	PUNCT
admet-544	278	5	1806–1813	1806–1813	NUM
admet-544	278	6	.	.	PUNCT
admet-544	279	1	[	[	X
admet-544	279	2	13	13	NUM
admet-544	279	3	]	]	PUNCT
admet-544	279	4	k.	k.	PROPN
admet-544	279	5	valko	valko	PROPN
admet-544	279	6	,	,	PUNCT
admet-544	279	7	c.	c.	PROPN
admet-544	279	8	m.	m.	PROPN
admet-544	279	9	du	du	PROPN
admet-544	279	10	,	,	PUNCT
admet-544	279	11	c.	c.	PROPN
admet-544	279	12	bevan	bevan	PROPN
admet-544	279	13	,	,	PUNCT
admet-544	279	14	d.	d.	PROPN
admet-544	279	15	reynolds	reynolds	PROPN
admet-544	279	16	,	,	PUNCT
admet-544	279	17	m.h	m.h	PROPN
admet-544	279	18	.	.	PROPN
admet-544	279	19	abraham	abraham	PROPN
admet-544	279	20	.	.	PUNCT
admet-544	280	1	rapid	rapid	ADJ
admet-544	280	2	-	-	PUNCT
admet-544	280	3	gradient	gradient	NOUN
admet-544	280	4	hplc	hplc	NOUN
admet-544	280	5	method	method	NOUN
admet-544	280	6	for	for	ADP
admet-544	280	7	measuring	measure	VERB
admet-544	280	8	drug	drug	NOUN
admet-544	280	9	interactions	interaction	NOUN
admet-544	280	10	with	with	ADP
admet-544	280	11	immobilised	immobilised	ADJ
admet-544	280	12	artificial	artificial	ADJ
admet-544	280	13	membrane	membrane	NOUN
admet-544	280	14	:	:	PUNCT
admet-544	280	15	comparison	comparison	NOUN
admet-544	280	16	with	with	ADP
admet-544	280	17	other	other	ADJ
admet-544	280	18	lipophilicity	lipophilicity	NOUN
admet-544	280	19	measures	measure	NOUN
admet-544	280	20	.	.	PUNCT
admet-544	281	1	j.	j.	PROPN
admet-544	281	2	pharm	pharm	PROPN
admet-544	281	3	.	.	PUNCT
admet-544	282	1	sci	sci	PROPN
admet-544	282	2	.	.	PROPN
admet-544	282	3	89	89	NUM
admet-544	282	4	(	(	PUNCT
admet-544	282	5	2000	2000	NUM
admet-544	282	6	)	)	PUNCT
admet-544	282	7	1085–1095	1085–1095	NUM
admet-544	282	8	.	.	PUNCT
admet-544	283	1	[	[	X
admet-544	283	2	14	14	NUM
admet-544	283	3	]	]	X
admet-544	283	4	k.l	k.l	PROPN
admet-544	283	5	.	.	PROPN
admet-544	283	6	valko	valko	PROPN
admet-544	283	7	,	,	PUNCT
admet-544	283	8	s.p	s.p	PROPN
admet-544	283	9	.	.	PROPN
admet-544	283	10	teague	teague	PROPN
admet-544	283	11	,	,	PUNCT
admet-544	283	12	c.	c.	PROPN
admet-544	283	13	pidgeon	pidgeon	PROPN
admet-544	283	14	.	.	PUNCT
admet-544	284	1	in	in	ADP
admet-544	284	2	vitro	vitro	X
admet-544	284	3	membrane	membrane	NOUN
admet-544	284	4	binding	bind	VERB
admet-544	284	5	and	and	CCONJ
admet-544	284	6	protein	protein	NOUN
admet-544	284	7	binding	bind	VERB
admet-544	284	8	(	(	PUNCT
admet-544	284	9	iam	iam	PROPN
admet-544	284	10	mb	mb	PROPN
admet-544	284	11	/	/	SYM
admet-544	284	12	pb	pb	X
admet-544	284	13	technology	technology	NOUN
admet-544	284	14	)	)	PUNCT
admet-544	284	15	to	to	PART
admet-544	284	16	estimate	estimate	VERB
admet-544	284	17	in	in	ADP
admet-544	284	18	vivo	vivo	ADJ
admet-544	284	19	distribution	distribution	NOUN
admet-544	284	20	:	:	PUNCT
admet-544	284	21	applications	application	NOUN
admet-544	284	22	in	in	ADP
admet-544	284	23	early	early	ADJ
admet-544	284	24	drug	drug	NOUN
admet-544	284	25	discovery	discovery	NOUN
admet-544	284	26	.	.	PUNCT
admet-544	285	1	admet	admet	PROPN
admet-544	285	2	dmpk	dmpk	PROPN
admet-544	285	3	5	5	NUM
admet-544	285	4	(	(	PUNCT
admet-544	285	5	2017	2017	NUM
admet-544	285	6	)	)	PUNCT
admet-544	285	7	14	14	NUM
admet-544	285	8	-	-	SYM
admet-544	285	9	38	38	NUM
admet-544	285	10	.	.	PUNCT
admet-544	286	1	[	[	X
admet-544	286	2	15	15	NUM
admet-544	286	3	]	]	X
admet-544	286	4	s.h	s.h	PROPN
admet-544	286	5	.	.	PROPN
admet-544	286	6	joo	joo	PROPN
admet-544	286	7	.	.	PUNCT
admet-544	287	1	cyclic	cyclic	ADJ
admet-544	287	2	peptides	peptide	NOUN
admet-544	287	3	as	as	ADP
admet-544	287	4	therapeutic	therapeutic	ADJ
admet-544	287	5	agents	agent	NOUN
admet-544	287	6	and	and	CCONJ
admet-544	287	7	biochemical	biochemical	ADJ
admet-544	287	8	tools	tool	NOUN
admet-544	287	9	.	.	PUNCT
admet-544	288	1	biomol	biomol	PROPN
admet-544	288	2	.	.	PUNCT
admet-544	289	1	ther	ther	INTJ
admet-544	289	2	.	.	PUNCT
admet-544	290	1	20	20	NUM
admet-544	290	2	(	(	PUNCT
admet-544	290	3	2012	2012	NUM
admet-544	290	4	)	)	PUNCT
admet-544	290	5	19–26	19–26	NOUN
admet-544	290	6	.	.	PUNCT
admet-544	291	1	[	[	X
admet-544	291	2	16	16	NUM
admet-544	291	3	]	]	X
admet-544	291	4	p.	p.	NOUN
admet-544	291	5	thansandote	thansandote	NOUN
admet-544	291	6	,	,	PUNCT
admet-544	291	7	r.m	r.m	PROPN
admet-544	291	8	.	.	PROPN
admet-544	291	9	harris	harris	PROPN
admet-544	291	10	,	,	PUNCT
admet-544	291	11	h.l	h.l	PROPN
admet-544	291	12	.	.	PROPN
admet-544	291	13	dexter	dexter	PROPN
admet-544	291	14	,	,	PUNCT
admet-544	291	15	g.l	g.l	PROPN
admet-544	291	16	.	.	PROPN
admet-544	291	17	simpson	simpson	PROPN
admet-544	291	18	,	,	PUNCT
admet-544	291	19	s.	s.	PROPN
admet-544	291	20	pal	pal	PROPN
admet-544	291	21	,	,	PUNCT
admet-544	291	22	r.j	r.j	PROPN
admet-544	291	23	.	.	PROPN
admet-544	291	24	upton	upton	PROPN
admet-544	291	25	,	,	PUNCT
admet-544	291	26	k.	k.	PROPN
admet-544	291	27	valko	valko	PROPN
admet-544	291	28	.	.	PUNCT
admet-544	292	1	improving	improve	VERB
admet-544	292	2	the	the	DET
admet-544	292	3	passive	passive	ADJ
admet-544	292	4	permeability	permeability	NOUN
admet-544	292	5	of	of	ADP
admet-544	292	6	macrocyclic	macrocyclic	NOUN
admet-544	292	7	peptides	peptide	NOUN
admet-544	292	8	:	:	PUNCT
admet-544	292	9	balancing	balance	VERB
admet-544	292	10	permeability	permeability	NOUN
admet-544	292	11	with	with	ADP
admet-544	292	12	other	other	ADJ
admet-544	292	13	physicochemical	physicochemical	ADJ
admet-544	292	14	properties	property	NOUN
admet-544	292	15	.	.	PUNCT
admet-544	293	1	bioorganic	bioorganic	PROPN
admet-544	293	2	med	med	PROPN
admet-544	293	3	.	.	PUNCT
admet-544	293	4	chem	chem	PROPN
admet-544	293	5	.	.	PUNCT
admet-544	294	1	23	23	NUM
admet-544	294	2	(	(	PUNCT
admet-544	294	3	2015	2015	NUM
admet-544	294	4	)	)	PUNCT
admet-544	295	1	322–327	322–327	NUM
admet-544	295	2	.	.	PUNCT
admet-544	296	1	[	[	X
admet-544	296	2	17	17	NUM
admet-544	296	3	]	]	X
admet-544	296	4	j.g	j.g	PROPN
admet-544	296	5	.	.	PROPN
admet-544	296	6	beck	beck	PROPN
admet-544	296	7	,	,	PUNCT
admet-544	296	8	j.	j.	PROPN
admet-544	296	9	chatterjee	chatterjee	PROPN
admet-544	296	10	,	,	PUNCT
admet-544	296	11	b.	b.	PROPN
admet-544	296	12	laufer	laufer	PROPN
admet-544	296	13	,	,	PUNCT
admet-544	296	14	m.u	m.u	PROPN
admet-544	296	15	.	.	PROPN
admet-544	296	16	kiran	kiran	PROPN
admet-544	296	17	,	,	PUNCT
admet-544	296	18	a.o	a.o	PROPN
admet-544	296	19	.	.	PROPN
admet-544	296	20	frank	frank	PROPN
admet-544	296	21	,	,	PUNCT
admet-544	296	22	s.	s.	PROPN
admet-544	296	23	neubauer	neubauer	PROPN
admet-544	296	24	,	,	PUNCT
admet-544	296	25	o.	o.	PROPN
admet-544	296	26	ovadia	ovadia	PROPN
admet-544	296	27	,	,	PUNCT
admet-544	296	28	s.	s.	PROPN
admet-544	296	29	greenberg	greenberg	PROPN
admet-544	296	30	,	,	PUNCT
admet-544	296	31	c.	c.	PROPN
admet-544	296	32	gilon	gilon	PROPN
admet-544	296	33	,	,	PUNCT
admet-544	296	34	a.	a.	NOUN
admet-544	296	35	hoffman	hoffman	PROPN
admet-544	296	36	,	,	PUNCT
admet-544	296	37	h.	h.	PROPN
admet-544	296	38	kessler	kessler	PROPN
admet-544	296	39	.	.	PUNCT
admet-544	297	1	intestinal	intestinal	ADJ
admet-544	297	2	permeability	permeability	NOUN
admet-544	297	3	of	of	ADP
admet-544	297	4	cyclic	cyclic	ADJ
admet-544	297	5	peptides	peptide	NOUN
admet-544	297	6	:	:	PUNCT
admet-544	297	7	common	common	ADJ
admet-544	297	8	key	key	ADJ
admet-544	297	9	backbone	backbone	NOUN
admet-544	297	10	motifs	motif	NOUN
admet-544	297	11	identified	identify	VERB
admet-544	297	12	.	.	PUNCT
admet-544	298	1	j.	j.	PROPN
admet-544	298	2	am	am	PROPN
admet-544	298	3	.	.	PUNCT
admet-544	299	1	chem	chem	NOUN
admet-544	299	2	.	.	PUNCT
admet-544	300	1	soc	soc	PROPN
admet-544	300	2	.	.	PUNCT
admet-544	301	1	134	134	NUM
admet-544	301	2	(	(	PUNCT
admet-544	301	3	2012	2012	NUM
admet-544	301	4	)	)	PUNCT
admet-544	301	5	12125–12133	12125–12133	NUM
admet-544	301	6	.	.	PUNCT
admet-544	302	1	[	[	X
admet-544	302	2	18	18	NUM
admet-544	302	3	]	]	X
admet-544	302	4	f.	f.	PROPN
admet-544	302	5	giordanetto	giordanetto	PROPN
admet-544	302	6	,	,	PUNCT
admet-544	302	7	j.	j.	PROPN
admet-544	302	8	kihlberg	kihlberg	PROPN
admet-544	302	9	.	.	PUNCT
admet-544	303	1	macrocyclic	macrocyclic	ADJ
admet-544	303	2	drugs	drug	NOUN
admet-544	303	3	and	and	CCONJ
admet-544	303	4	clinical	clinical	ADJ
admet-544	303	5	candidates	candidate	NOUN
admet-544	303	6	:	:	PUNCT
admet-544	303	7	what	what	PRON
admet-544	303	8	can	can	AUX
admet-544	303	9	medicinal	medicinal	ADJ
admet-544	303	10	chemists	chemist	NOUN
admet-544	303	11	learn	learn	VERB
admet-544	303	12	from	from	ADP
admet-544	303	13	their	their	PRON
admet-544	303	14	properties	property	NOUN
admet-544	303	15	?	?	PUNCT
admet-544	303	16	.	.	PUNCT
admet-544	304	1	j.	j.	PROPN
admet-544	304	2	med	med	PROPN
admet-544	304	3	.	.	PROPN
admet-544	304	4	chem	chem	PROPN
admet-544	304	5	.	.	PUNCT
admet-544	305	1	57	57	NUM
admet-544	305	2	(	(	PUNCT
admet-544	305	3	2014	2014	NUM
admet-544	305	4	)	)	PUNCT
admet-544	306	1	278–295	278–295	NUM
admet-544	306	2	.	.	PUNCT
admet-544	307	1	[	[	X
admet-544	307	2	19	19	NUM
admet-544	307	3	]	]	X
admet-544	307	4	n.c	n.c	PROPN
admet-544	307	5	.	.	PROPN
admet-544	307	6	tan	tan	PROPN
admet-544	307	7	,	,	PUNCT
admet-544	307	8	p.	p.	PROPN
admet-544	307	9	yu	yu	PROPN
admet-544	307	10	,	,	PUNCT
admet-544	307	11	y.u	y.u	PROPN
admet-544	307	12	.	.	PROPN
admet-544	307	13	kwon	kwon	PROPN
admet-544	307	14	,	,	PUNCT
admet-544	307	15	t.	t.	PROPN
admet-544	307	16	kodadek	kodadek	PROPN
admet-544	307	17	.	.	PUNCT
admet-544	308	1	high	high	ADJ
admet-544	308	2	-	-	PUNCT
admet-544	308	3	throughput	throughput	NOUN
admet-544	308	4	evaluation	evaluation	NOUN
admet-544	308	5	of	of	ADP
admet-544	308	6	relative	relative	ADJ
admet-544	308	7	cell	cell	NOUN
admet-544	308	8	permeability	permeability	NOUN
admet-544	308	9	between	between	ADP
admet-544	308	10	peptoids	peptoid	NOUN
admet-544	308	11	and	and	CCONJ
admet-544	308	12	peptides	peptide	NOUN
admet-544	308	13	.	.	PUNCT
admet-544	309	1	bioorganic	bioorganic	PROPN
admet-544	309	2	med	med	PROPN
admet-544	309	3	.	.	PROPN
admet-544	309	4	chem	chem	PROPN
admet-544	309	5	.	.	PUNCT
admet-544	310	1	16	16	NUM
admet-544	310	2	(	(	PUNCT
admet-544	310	3	2008	2008	NUM
admet-544	310	4	)	)	PUNCT
admet-544	310	5	5853–5861	5853–5861	NUM
admet-544	310	6	.	.	PUNCT
admet-544	311	1	[	[	X
admet-544	311	2	20	20	NUM
admet-544	311	3	]	]	PUNCT
admet-544	311	4	b.	b.	PROPN
admet-544	311	5	testa	testa	PROPN
admet-544	311	6	,	,	PUNCT
admet-544	311	7	p.	p.	NOUN
admet-544	311	8	crivori	crivori	NOUN
admet-544	311	9	,	,	PUNCT
admet-544	311	10	m.	m.	NOUN
admet-544	311	11	reist	reist	PROPN
admet-544	311	12	,	,	PUNCT
admet-544	311	13	p.a	p.a	PROPN
admet-544	311	14	.	.	PUNCT
admet-544	311	15	carrupt	carrupt	PROPN
admet-544	311	16	.	.	PUNCT
admet-544	312	1	the	the	DET
admet-544	312	2	influence	influence	NOUN
admet-544	312	3	of	of	ADP
admet-544	312	4	lipophilicity	lipophilicity	NOUN
admet-544	312	5	on	on	ADP
admet-544	312	6	the	the	DET
admet-544	312	7	pharmacokinetic	pharmacokinetic	ADJ
admet-544	312	8	behavior	behavior	NOUN
admet-544	312	9	of	of	ADP
admet-544	312	10	drugs	drug	NOUN
admet-544	312	11	:	:	PUNCT
admet-544	312	12	concepts	concept	NOUN
admet-544	312	13	and	and	CCONJ
admet-544	312	14	examples	example	NOUN
admet-544	312	15	.	.	PUNCT
admet-544	313	1	perspect	perspect	VERB
admet-544	313	2	.	.	PUNCT
admet-544	314	1	drug	drug	NOUN
admet-544	314	2	discov	discov	NOUN
admet-544	314	3	.	.	PUNCT
admet-544	315	1	des	des	PROPN
admet-544	315	2	.	.	PROPN
admet-544	315	3	19	19	NUM
admet-544	315	4	(	(	PUNCT
admet-544	315	5	2000	2000	NUM
admet-544	315	6	)	)	PUNCT
admet-544	315	7	179–211	179–211	NUM
admet-544	315	8	.	.	PUNCT
admet-544	316	1	[	[	X
admet-544	316	2	21	21	NUM
admet-544	316	3	]	]	X
admet-544	316	4	r.	r.	PROPN
admet-544	316	5	gulaboski	gulaboski	PROPN
admet-544	316	6	,	,	PUNCT
admet-544	316	7	f.	f.	PROPN
admet-544	316	8	scholz	scholz	PROPN
admet-544	316	9	.	.	PUNCT
admet-544	317	1	lipophilicity	lipophilicity	NOUN
admet-544	317	2	of	of	ADP
admet-544	317	3	peptide	peptide	ADJ
admet-544	317	4	anions	anion	NOUN
admet-544	317	5	:	:	PUNCT
admet-544	317	6	an	an	DET
admet-544	317	7	experimental	experimental	ADJ
admet-544	317	8	data	datum	NOUN
admet-544	317	9	set	set	VERB
admet-544	317	10	for	for	ADP
admet-544	317	11	lipophilicity	lipophilicity	NOUN
admet-544	317	12	calculations	calculation	NOUN
admet-544	317	13	.	.	PUNCT
admet-544	318	1	j.	j.	PROPN
admet-544	318	2	phys	phys	PROPN
admet-544	318	3	.	.	PUNCT
admet-544	319	1	chem	chem	PROPN
admet-544	319	2	.	.	PUNCT
admet-544	320	1	b	b	X
admet-544	320	2	(	(	PUNCT
admet-544	320	3	2003	2003	NUM
admet-544	320	4	)	)	PUNCT
admet-544	320	5	5650–5657	5650–5657	NUM
admet-544	320	6	.	.	PUNCT
admet-544	321	1	[	[	X
admet-544	321	2	22	22	NUM
admet-544	321	3	]	]	PUNCT
admet-544	321	4	a.	a.	NOUN
admet-544	321	5	visconti	visconti	PROPN
admet-544	321	6	,	,	PUNCT
admet-544	321	7	g.	g.	PROPN
admet-544	321	8	ermondi	ermondi	PROPN
admet-544	321	9	,	,	PUNCT
admet-544	321	10	g.	g.	PROPN
admet-544	321	11	caron	caron	PROPN
admet-544	321	12	,	,	PUNCT
admet-544	321	13	r.	r.	PROPN
admet-544	321	14	esposito	esposito	PROPN
admet-544	321	15	.	.	PROPN
admet-544	321	16	prediction	prediction	NOUN
admet-544	321	17	and	and	CCONJ
admet-544	321	18	interpretation	interpretation	NOUN
admet-544	321	19	of	of	ADP
admet-544	321	20	the	the	DET
admet-544	321	21	lipophilicity	lipophilicity	NOUN
admet-544	321	22	of	of	ADP
admet-544	321	23	small	small	ADJ
admet-544	321	24	peptides	peptide	NOUN
admet-544	321	25	.	.	PUNCT
admet-544	322	1	j.	j.	PROPN
admet-544	322	2	comput	comput	PROPN
admet-544	322	3	.	.	PUNCT
admet-544	322	4	aided	aid	VERB
admet-544	322	5	.	.	PUNCT
admet-544	323	1	mol	mol	X
admet-544	323	2	.	.	PUNCT
admet-544	324	1	des	des	PROPN
admet-544	324	2	.	.	PROPN
admet-544	324	3	29	29	NUM
admet-544	324	4	(	(	PUNCT
admet-544	324	5	2015	2015	NUM
admet-544	324	6	)	)	PUNCT
admet-544	324	7	361–370	361–370	NUM
admet-544	324	8	.	.	PUNCT
admet-544	325	1	[	[	X
admet-544	325	2	23	23	NUM
admet-544	325	3	]	]	X
admet-544	325	4	g.	g.	PROPN
admet-544	325	5	ermondi	ermondi	PROPN
admet-544	325	6	,	,	PUNCT
admet-544	325	7	f.	f.	PROPN
admet-544	325	8	catalano	catalano	PROPN
admet-544	325	9	,	,	PUNCT
admet-544	325	10	m.	m.	NOUN
admet-544	325	11	vallaro	vallaro	NOUN
admet-544	325	12	,	,	PUNCT
admet-544	325	13	i.	i.	NOUN
admet-544	325	14	ermondi	ermondi	PROPN
admet-544	325	15	,	,	PUNCT
admet-544	325	16	m.p	m.p	PROPN
admet-544	325	17	.	.	PROPN
admet-544	325	18	leal	leal	PROPN
admet-544	325	19	,	,	PUNCT
admet-544	325	20	l.	l.	PROPN
admet-544	325	21	rinaldi	rinaldi	PROPN
admet-544	325	22	,	,	PUNCT
admet-544	325	23	s.	s.	PROPN
admet-544	325	24	visentin	visentin	PROPN
admet-544	325	25	,	,	PUNCT
admet-544	325	26	g.	g.	PROPN
admet-544	325	27	caron	caron	PROPN
admet-544	325	28	.	.	PUNCT
admet-544	326	1	lipophilicity	lipophilicity	NOUN
admet-544	326	2	of	of	ADP
admet-544	326	3	amyloid	amyloid	NOUN
admet-544	326	4	β	β	NOUN
admet-544	326	5	-	-	NOUN
admet-544	326	6	peptide	peptide	ADJ
admet-544	326	7	12	12	NUM
admet-544	326	8	-	-	SYM
admet-544	326	9	28	28	NUM
admet-544	326	10	and	and	CCONJ
admet-544	326	11	25	25	NUM
admet-544	326	12	-	-	SYM
admet-544	326	13	35	35	NUM
admet-544	326	14	to	to	PART
admet-544	326	15	unravel	unravel	VERB
admet-544	326	16	their	their	PRON
admet-544	326	17	ability	ability	NOUN
admet-544	326	18	to	to	PART
admet-544	326	19	promote	promote	VERB
admet-544	326	20	hydrophobic	hydrophobic	NOUN
admet-544	326	21	and	and	CCONJ
admet-544	326	22	electrostatic	electrostatic	ADJ
admet-544	326	23	interactions	interaction	NOUN
admet-544	326	24	.	.	PUNCT
admet-544	327	1	int	int	NOUN
admet-544	327	2	.	.	PUNCT
admet-544	328	1	j.	j.	PROPN
admet-544	328	2	pharm	pharm	PROPN
admet-544	328	3	.	.	PUNCT
admet-544	329	1	495	495	NUM
admet-544	329	2	(	(	PUNCT
admet-544	329	3	2015	2015	NUM
admet-544	329	4	)	)	PUNCT
admet-544	330	1	179–185	179–185	NUM
admet-544	330	2	.	.	PUNCT
admet-544	331	1	[	[	X
admet-544	331	2	24	24	NUM
admet-544	331	3	]	]	X
admet-544	331	4	j.l	j.l	PROPN
admet-544	331	5	.	.	PROPN
admet-544	331	6	meek	meek	PROPN
admet-544	331	7	.	.	PUNCT
admet-544	332	1	prediction	prediction	NOUN
admet-544	332	2	of	of	ADP
admet-544	332	3	peptide	peptide	ADJ
admet-544	332	4	retention	retention	NOUN
admet-544	332	5	times	time	NOUN
admet-544	332	6	in	in	ADP
admet-544	332	7	high	high	ADJ
admet-544	332	8	-	-	PUNCT
admet-544	332	9	pressure	pressure	NOUN
admet-544	332	10	liquid	liquid	ADJ
admet-544	332	11	chromatography	chromatography	NOUN
admet-544	332	12	on	on	ADP
admet-544	332	13	the	the	DET
admet-544	332	14	basis	basis	NOUN
admet-544	332	15	of	of	ADP
admet-544	332	16	amino	amino	NOUN
admet-544	332	17	acid	acid	NOUN
admet-544	332	18	composition	composition	NOUN
admet-544	332	19	.	.	PUNCT
admet-544	333	1	proc	proc	PROPN
admet-544	333	2	.	.	PUNCT
admet-544	334	1	natl	natl	PROPN
admet-544	334	2	.	.	PUNCT
admet-544	335	1	acad	acad	PROPN
admet-544	335	2	.	.	PUNCT
admet-544	336	1	sci	sci	PROPN
admet-544	336	2	.	.	PROPN
admet-544	337	1	77	77	NUM
admet-544	337	2	(	(	PUNCT
admet-544	337	3	1980	1980	NUM
admet-544	337	4	)	)	PUNCT
admet-544	337	5	1632–1636	1632–1636	NUM
admet-544	337	6	.	.	PUNCT
admet-544	338	1	[	[	X
admet-544	338	2	25	25	NUM
admet-544	338	3	]	]	X
admet-544	338	4	k.m	k.m	PROPN
admet-544	338	5	.	.	PROPN
admet-544	338	6	biswas	biswas	PROPN
admet-544	338	7	,	,	PUNCT
admet-544	338	8	d.r	d.r	PROPN
admet-544	338	9	.	.	PROPN
admet-544	338	10	devido	devido	PROPN
admet-544	338	11	,	,	PUNCT
admet-544	338	12	j.g	j.g	PROPN
admet-544	338	13	.	.	PROPN
admet-544	338	14	dorsey	dorsey	PROPN
admet-544	338	15	.	.	PUNCT
admet-544	339	1	evaluation	evaluation	NOUN
admet-544	339	2	of	of	ADP
admet-544	339	3	methods	method	NOUN
admet-544	339	4	for	for	ADP
admet-544	339	5	measuring	measure	VERB
admet-544	339	6	amino	amino	NOUN
admet-544	339	7	acid	acid	NOUN
admet-544	339	8	hydrophobicities	hydrophobicity	NOUN
admet-544	339	9	and	and	CCONJ
admet-544	339	10	interactions	interaction	NOUN
admet-544	339	11	.	.	PUNCT
admet-544	340	1	j.	j.	PROPN
admet-544	340	2	chromatogr	chromatogr	PROPN
admet-544	340	3	.	.	PUNCT
admet-544	341	1	a	a	DET
admet-544	341	2	1000	1000	NUM
admet-544	341	3	(	(	PUNCT
admet-544	341	4	2003	2003	NUM
admet-544	341	5	)	)	PUNCT
admet-544	341	6	637–655	637–655	NUM
admet-544	341	7	.	.	PUNCT
admet-544	342	1	[	[	X
admet-544	342	2	26	26	NUM
admet-544	342	3	]	]	X
admet-544	342	4	c.t	c.t	PROPN
admet-544	342	5	.	.	PROPN
admet-544	342	6	mant	mant	PROPN
admet-544	342	7	,	,	PUNCT
admet-544	342	8	r.s	r.s	PROPN
admet-544	342	9	.	.	PROPN
admet-544	342	10	hodges	hodges	PROPN
admet-544	342	11	.	.	PUNCT
admet-544	342	12	reversed	reverse	VERB
admet-544	342	13	-	-	PUNCT
admet-544	342	14	phase	phase	NOUN
admet-544	342	15	liquid	liquid	ADJ
admet-544	342	16	chromatography	chromatography	NOUN
admet-544	342	17	as	as	ADP
admet-544	342	18	a	a	DET
admet-544	342	19	tool	tool	NOUN
admet-544	342	20	in	in	ADP
admet-544	342	21	the	the	DET
admet-544	342	22	determination	determination	NOUN
admet-544	342	23	of	of	ADP
admet-544	342	24	the	the	DET
admet-544	342	25	hydrophilicity	hydrophilicity	NOUN
admet-544	342	26	/	/	SYM
admet-544	342	27	hydrophobicity	hydrophobicity	NOUN
admet-544	342	28	of	of	ADP
admet-544	342	29	amino	amino	NOUN
admet-544	342	30	acid	acid	NOUN
admet-544	342	31	side	side	NOUN
admet-544	342	32	-	-	PUNCT
admet-544	342	33	chains	chain	NOUN
admet-544	342	34	at	at	ADP
admet-544	342	35	a	a	DET
admet-544	342	36	ligand	ligand	ADJ
admet-544	342	37	-	-	PUNCT
admet-544	342	38	receptor	receptor	NOUN
admet-544	342	39	interface	interface	NOUN
admet-544	342	40	in	in	ADP
admet-544	342	41	the	the	DET
admet-544	342	42	presence	presence	NOUN
admet-544	342	43	of	of	ADP
admet-544	342	44	different	different	ADJ
admet-544	342	45	aqueous	aqueous	ADJ
admet-544	342	46	environments	environment	NOUN
admet-544	342	47	:	:	PUNCT
admet-544	342	48	ii	ii	X
admet-544	342	49	.	.	PROPN
admet-544	342	50	effect	effect	NOUN
admet-544	342	51	of	of	ADP
admet-544	342	52	varying	vary	VERB
admet-544	342	53	peptide	peptide	ADJ
admet-544	342	54	ligand	ligand	NOUN
admet-544	342	55	hydro	hydro	PROPN
admet-544	342	56	.	.	PUNCT
admet-544	343	1	j.	j.	PROPN
admet-544	343	2	chromatogr	chromatogr	PROPN
admet-544	343	3	.	.	PUNCT
admet-544	344	1	a	a	DET
admet-544	344	2	972	972	NUM
admet-544	344	3	(	(	PUNCT
admet-544	344	4	2002	2002	NUM
admet-544	344	5	)	)	PUNCT
admet-544	344	6	61–75	61–75	NUM
admet-544	344	7	.	.	PUNCT
admet-544	345	1	[	[	X
admet-544	345	2	27	27	NUM
admet-544	345	3	]	]	X
admet-544	345	4	c.	c.	PROPN
admet-544	345	5	vraka	vraka	PROPN
admet-544	345	6	,	,	PUNCT
admet-544	345	7	s.	s.	PROPN
admet-544	345	8	mijailović	mijailović	PROPN
admet-544	345	9	,	,	PUNCT
admet-544	345	10	v.	v.	PROPN
admet-544	345	11	fröhlich	fröhlich	PROPN
admet-544	345	12	,	,	PUNCT
admet-544	345	13	m.	m.	NOUN
admet-544	345	14	mitterhauser	mitterhauser	NOUN
admet-544	345	15	.	.	PUNCT
admet-544	346	1	expanding	expand	VERB
admet-544	346	2	logp	logp	NOUN
admet-544	346	3	:	:	PUNCT
admet-544	346	4	present	present	ADJ
admet-544	346	5	possibilities	possibility	NOUN
admet-544	346	6	.	.	PUNCT
admet-544	347	1	nucl	nucl	PROPN
admet-544	347	2	.	.	PUNCT
admet-544	348	1	med	med	PROPN
admet-544	348	2	.	.	PUNCT
admet-544	349	1	biol	biol	PROPN
admet-544	349	2	.	.	PUNCT
admet-544	350	1	58	58	NUM
admet-544	350	2	(	(	PUNCT
admet-544	350	3	2013	2013	NUM
admet-544	350	4	)	)	PUNCT
admet-544	350	5	20–32	20–32	NUM
admet-544	350	6	.	.	PUNCT
admet-544	351	1	admet	admet	PROPN
admet-544	351	2	&	&	CCONJ
admet-544	351	3	dmpk	dmpk	PROPN
admet-544	351	4	6(2	6(2	NUM
admet-544	351	5	)	)	PUNCT
admet-544	351	6	(	(	PUNCT
admet-544	351	7	2018	2018	NUM
admet-544	351	8	)	)	PUNCT
admet-544	351	9	162	162	NUM
admet-544	351	10	-	-	SYM
admet-544	351	11	175	175	NUM
admet-544	351	12	biomimetic	biomimetic	ADJ
admet-544	351	13	hplc	hplc	NOUN
admet-544	351	14	in	in	ADP
admet-544	351	15	the	the	DET
admet-544	351	16	estimation	estimation	NOUN
admet-544	351	17	of	of	ADP
admet-544	351	18	physchem	physchem	NOUN
admet-544	351	19	properties	property	NOUN
admet-544	351	20	of	of	ADP
admet-544	351	21	peptides	peptide	NOUN
admet-544	351	22	doi	doi	NOUN
admet-544	351	23	:	:	PUNCT
admet-544	351	24	10.5599	10.5599	NUM
admet-544	351	25	/	/	SYM
admet-544	351	26	admet.544	admet.544	PROPN
admet-544	351	27	175	175	NUM
admet-544	352	1	[	[	X
admet-544	352	2	28	28	NUM
admet-544	352	3	]	]	X
admet-544	352	4	k.m	k.m	PROPN
admet-544	352	5	.	.	PROPN
admet-544	352	6	biswas	biswas	PROPN
admet-544	352	7	,	,	PUNCT
admet-544	352	8	d.r	d.r	PROPN
admet-544	352	9	.	.	PROPN
admet-544	352	10	devido	devido	PROPN
admet-544	352	11	,	,	PUNCT
admet-544	352	12	j.g	j.g	PROPN
admet-544	352	13	.	.	PROPN
admet-544	352	14	dorsey	dorsey	PROPN
admet-544	352	15	.	.	PUNCT
admet-544	352	16	evaluation	evaluation	NOUN
admet-544	352	17	of	of	ADP
admet-544	352	18	methods	method	NOUN
admet-544	352	19	for	for	ADP
admet-544	352	20	measuring	measure	VERB
admet-544	352	21	amino	amino	ADJ
admet-544	352	22	acids	acid	NOUN
admet-544	352	23	hydrophobicities	hydrophobicity	NOUN
admet-544	352	24	and	and	CCONJ
admet-544	352	25	interactions	interaction	NOUN
admet-544	352	26	.	.	PUNCT
admet-544	353	1	j.	j.	PROPN
admet-544	353	2	chromatogr	chromatogr	PROPN
admet-544	353	3	.	.	PUNCT
admet-544	354	1	a	a	DET
admet-544	354	2	1000	1000	NUM
admet-544	354	3	(	(	PUNCT
admet-544	354	4	2003	2003	NUM
admet-544	354	5	)	)	PUNCT
admet-544	354	6	637	637	NUM
admet-544	354	7	-	-	SYM
admet-544	354	8	655	655	NUM
admet-544	354	9	.	.	PUNCT
admet-544	355	1	[	[	X
admet-544	355	2	29	29	NUM
admet-544	355	3	]	]	X
admet-544	355	4	d.	d.	PROPN
admet-544	355	5	gussakovsky	gussakovsky	PROPN
admet-544	355	6	,	,	PUNCT
admet-544	355	7	h.	h.	PROPN
admet-544	355	8	neustaeter	neustaeter	PROPN
admet-544	355	9	,	,	PUNCT
admet-544	355	10	v.	v.	PROPN
admet-544	355	11	spicer	spicer	PROPN
admet-544	355	12	,	,	PUNCT
admet-544	355	13	o.	o.	PROPN
admet-544	355	14	krokhine	krokhine	PROPN
admet-544	355	15	.	.	PUNCT
admet-544	356	1	peptide	peptide	ADJ
admet-544	356	2	retention	retention	NOUN
admet-544	356	3	time	time	NOUN
admet-544	356	4	prediction	prediction	NOUN
admet-544	356	5	for	for	ADP
admet-544	356	6	immobilized	immobilized	ADJ
admet-544	356	7	artificial	artificial	PROPN
admet-544	356	8	k.m	k.m	PROPN
admet-544	356	9	.	.	PROPN
admet-544	356	10	biswas	biswas	PROPN
admet-544	356	11	,	,	PUNCT
admet-544	356	12	d.r	d.r	PROPN
admet-544	356	13	.	.	PROPN
admet-544	356	14	devido	devido	PROPN
admet-544	356	15	,	,	PUNCT
admet-544	356	16	j.g	j.g	PROPN
admet-544	356	17	.	.	PROPN
admet-544	356	18	dorsey	dorsey	PROPN
admet-544	356	19	.	.	PUNCT
admet-544	357	1	evaluation	evaluation	NOUN
admet-544	357	2	of	of	ADP
admet-544	357	3	methods	method	NOUN
admet-544	357	4	for	for	ADP
admet-544	357	5	measuring	measure	VERB
admet-544	357	6	amino	amino	ADJ
admet-544	357	7	acids	acid	NOUN
admet-544	357	8	hydrophobicities	hydrophobicity	NOUN
admet-544	357	9	and	and	CCONJ
admet-544	357	10	interactions	interaction	NOUN
admet-544	357	11	.	.	PUNCT
admet-544	358	1	j.	j.	PROPN
admet-544	358	2	chromatogr	chromatogr	PROPN
admet-544	358	3	.	.	PUNCT
admet-544	359	1	a	a	DET
admet-544	359	2	1000	1000	NUM
admet-544	359	3	(	(	PUNCT
admet-544	359	4	2003	2003	NUM
admet-544	359	5	)	)	PUNCT
admet-544	359	6	637	637	NUM
admet-544	359	7	-	-	PUNCT
admet-544	359	8	50655membrane	50655membrane	NUM
admet-544	359	9	phosphatydilcholine	phosphatydilcholine	NOUN
admet-544	359	10	stationary	stationary	ADJ
admet-544	359	11	phase	phase	NOUN
admet-544	359	12	:	:	PUNCT
admet-544	359	13	method	method	NOUN
admet-544	359	14	development	development	NOUN
admet-544	359	15	and	and	CCONJ
admet-544	359	16	preliminary	preliminary	ADJ
admet-544	359	17	observations	observation	NOUN
admet-544	359	18	.	.	PUNCT
admet-544	360	1	admet	admet	PROPN
admet-544	360	2	dmpk	dmpk	PROPN
admet-544	360	3	(	(	PUNCT
admet-544	360	4	2018	2018	NUM
admet-544	360	5	)	)	PUNCT
admet-544	360	6	doi	doi	NOUN
admet-544	360	7	:	:	PUNCT
admet-544	360	8	http://dx.doi.org/10.5599/admet.520	http://dx.doi.org/10.5599/admet.520	NOUN
admet-544	360	9	.	.	PUNCT
admet-544	361	1	[	[	X
admet-544	361	2	30	30	NUM
admet-544	361	3	]	]	PUNCT
admet-544	361	4	k.	k.	PROPN
admet-544	361	5	valko	valko	PROPN
admet-544	361	6	.	.	PUNCT
admet-544	362	1	lipophilicity	lipophilicity	PROPN
admet-544	362	2	and	and	CCONJ
admet-544	362	3	biomimetic	biomimetic	ADJ
admet-544	362	4	properties	property	NOUN
admet-544	362	5	measured	measure	VERB
admet-544	362	6	by	by	ADP
admet-544	362	7	hplc	hplc	NOUN
admet-544	362	8	to	to	PART
admet-544	362	9	support	support	VERB
admet-544	362	10	drug	drug	NOUN
admet-544	362	11	discovery	discovery	NOUN
admet-544	362	12	.	.	PUNCT
admet-544	363	1	j.	j.	PROPN
admet-544	363	2	pharm	pharm	PROPN
admet-544	363	3	.	.	PUNCT
admet-544	363	4	biomed	biome	VERB
admet-544	363	5	.	.	PUNCT
admet-544	364	1	anal	anal	ADJ
admet-544	364	2	.	.	PUNCT
admet-544	365	1	130	130	NUM
admet-544	365	2	(	(	PUNCT
admet-544	365	3	2016	2016	NUM
admet-544	365	4	)	)	PUNCT
admet-544	365	5	35–54	35–54	NUM
admet-544	365	6	.	.	PUNCT
admet-544	366	1	[	[	X
admet-544	366	2	31	31	NUM
admet-544	366	3	]	]	X
admet-544	366	4	f.	f.	PROPN
admet-544	366	5	tsopelas	tsopelas	PROPN
admet-544	366	6	,	,	PUNCT
admet-544	366	7	c.	c.	PROPN
admet-544	366	8	giaginis	giaginis	PROPN
admet-544	366	9	,	,	PUNCT
admet-544	366	10	a.	a.	NOUN
admet-544	366	11	tsantili	tsantili	NOUN
admet-544	366	12	-	-	PUNCT
admet-544	366	13	kakoulidou	kakoulidou	NOUN
admet-544	366	14	.	.	PUNCT
admet-544	366	15	lipophilicity	lipophilicity	PROPN
admet-544	366	16	and	and	CCONJ
admet-544	366	17	biomimetic	biomimetic	ADJ
admet-544	366	18	properties	property	NOUN
admet-544	366	19	to	to	PART
admet-544	366	20	support	support	VERB
admet-544	366	21	drug	drug	NOUN
admet-544	366	22	discovery	discovery	NOUN
admet-544	366	23	.	.	PUNCT
admet-544	367	1	expert	expert	ADJ
admet-544	367	2	opinion	opinion	NOUN
admet-544	367	3	on	on	ADP
admet-544	367	4	drug	drug	NOUN
admet-544	367	5	discovery	discovery	NOUN
admet-544	367	6	12	12	NUM
admet-544	367	7	(	(	PUNCT
admet-544	367	8	2017	2017	NUM
admet-544	367	9	)	)	PUNCT
admet-544	367	10	885	885	NUM
admet-544	367	11	-	-	SYM
admet-544	367	12	896	896	NUM
admet-544	367	13	.	.	PUNCT
admet-544	368	1	[	[	X
admet-544	368	2	32	32	NUM
admet-544	368	3	]	]	PUNCT
admet-544	368	4	k.	k.	PROPN
admet-544	368	5	valko	valko	PROPN
admet-544	368	6	,	,	PUNCT
admet-544	368	7	c.	c.	PROPN
admet-544	368	8	du	du	PROPN
admet-544	368	9	,	,	PUNCT
admet-544	368	10	c.	c.	PROPN
admet-544	368	11	bevan	bevan	PROPN
admet-544	368	12	,	,	PUNCT
admet-544	368	13	d.	d.	PROPN
admet-544	368	14	reynolds	reynolds	PROPN
admet-544	368	15	,	,	PUNCT
admet-544	368	16	m.	m.	PROPN
admet-544	368	17	abraham	abraham	PROPN
admet-544	368	18	.	.	PUNCT
admet-544	369	1	rapid	rapid	ADJ
admet-544	369	2	method	method	NOUN
admet-544	369	3	for	for	ADP
admet-544	369	4	the	the	DET
admet-544	369	5	estimation	estimation	NOUN
admet-544	369	6	of	of	ADP
admet-544	369	7	octanol	octanol	NOUN
admet-544	369	8	/	/	SYM
admet-544	369	9	water	water	NOUN
admet-544	369	10	partition	partition	NOUN
admet-544	369	11	coefficient	coefficient	NOUN
admet-544	369	12	(	(	PUNCT
admet-544	369	13	log	log	PROPN
admet-544	369	14	poct	poct	PROPN
admet-544	369	15	)	)	PUNCT
admet-544	369	16	from	from	ADP
admet-544	369	17	gradient	gradient	ADJ
admet-544	369	18	rp	rp	NOUN
admet-544	369	19	-	-	PUNCT
admet-544	369	20	hplc	hplc	NOUN
admet-544	369	21	retention	retention	NOUN
admet-544	369	22	and	and	CCONJ
admet-544	369	23	a	a	DET
admet-544	369	24	hydrogen	hydrogen	NOUN
admet-544	369	25	bond	bond	NOUN
admet-544	369	26	acidity	acidity	NOUN
admet-544	369	27	term	term	NOUN
admet-544	369	28	(	(	PUNCT
admet-544	369	29	sigma	sigma	NOUN
admet-544	369	30	alpha2h	alpha2h	ADV
admet-544	369	31	)	)	PUNCT
admet-544	369	32	.	.	PUNCT
admet-544	370	1	curr	curr	AUX
admet-544	370	2	.	.	PUNCT
admet-544	370	3	med	med	PROPN
admet-544	370	4	.	.	PROPN
admet-544	370	5	chem	chem	PROPN
admet-544	370	6	.	.	PUNCT
admet-544	371	1	8	8	NUM
admet-544	371	2	(	(	PUNCT
admet-544	371	3	2001	2001	NUM
admet-544	371	4	)	)	PUNCT
admet-544	371	5	1137–1146	1137–1146	NUM
admet-544	371	6	.	.	PUNCT
admet-544	372	1	[	[	X
admet-544	372	2	33	33	NUM
admet-544	372	3	]	]	PUNCT
admet-544	372	4	f.	f.	PROPN
admet-544	372	5	hollosy	hollosy	PROPN
admet-544	372	6	,	,	PUNCT
admet-544	372	7	k.	k.	PROPN
admet-544	372	8	valkó	valkó	PROPN
admet-544	372	9	,	,	PUNCT
admet-544	372	10	a.	a.	NOUN
admet-544	372	11	hersey	hersey	PROPN
admet-544	372	12	,	,	PUNCT
admet-544	372	13	s.	s.	PROPN
admet-544	372	14	nunhuck	nunhuck	PROPN
admet-544	372	15	,	,	PUNCT
admet-544	372	16	g.	g.	PROPN
admet-544	372	17	kéri	kéri	PROPN
admet-544	372	18	,	,	PUNCT
admet-544	372	19	c.	c.	PROPN
admet-544	372	20	bevan	bevan	PROPN
admet-544	372	21	.	.	PUNCT
admet-544	373	1	estimation	estimation	NOUN
admet-544	373	2	of	of	ADP
admet-544	373	3	volume	volume	NOUN
admet-544	373	4	of	of	ADP
admet-544	373	5	distribution	distribution	NOUN
admet-544	373	6	in	in	ADP
admet-544	373	7	humans	human	NOUN
admet-544	373	8	from	from	ADP
admet-544	373	9	hplc	hplc	NOUN
admet-544	373	10	measurements	measurement	NOUN
admet-544	373	11	of	of	ADP
admet-544	373	12	human	human	ADJ
admet-544	373	13	serum	serum	NOUN
admet-544	373	14	albumin	albumin	NOUN
admet-544	373	15	binding	bind	VERB
admet-544	373	16	and	and	CCONJ
admet-544	373	17	immobilized	immobilize	VERB
admet-544	373	18	artificial	artificial	ADJ
admet-544	373	19	membrane	membrane	NOUN
admet-544	373	20	partitioning	partitioning	NOUN
admet-544	373	21	.	.	PUNCT
admet-544	374	1	j.	j.	PROPN
admet-544	374	2	med	med	PROPN
admet-544	374	3	.	.	PROPN
admet-544	374	4	chem	chem	PROPN
admet-544	374	5	.	.	PUNCT
admet-544	375	1	49	49	NUM
admet-544	375	2	(	(	PUNCT
admet-544	375	3	2006	2006	NUM
admet-544	375	4	)	)	PUNCT
admet-544	375	5	6958–6971	6958–6971	NUM
admet-544	375	6	.	.	PUNCT
admet-544	376	1	[	[	X
admet-544	376	2	34	34	NUM
admet-544	376	3	]	]	PUNCT
admet-544	376	4	k.	k.	PROPN
admet-544	376	5	valko	valko	PROPN
admet-544	376	6	,	,	PUNCT
admet-544	376	7	s.	s.	PROPN
admet-544	376	8	nunhuck	nunhuck	PROPN
admet-544	376	9	,	,	PUNCT
admet-544	376	10	c.	c.	PROPN
admet-544	376	11	bevan	bevan	PROPN
admet-544	376	12	,	,	PUNCT
admet-544	376	13	m.h	m.h	PROPN
admet-544	376	14	.	.	PROPN
admet-544	376	15	abraham	abraham	PROPN
admet-544	376	16	,	,	PUNCT
admet-544	376	17	d.p	d.p	PROPN
admet-544	376	18	.	.	PROPN
admet-544	376	19	reynolds	reynolds	PROPN
admet-544	376	20	.	.	PUNCT
admet-544	377	1	fast	fast	ADJ
admet-544	377	2	gradient	gradient	NOUN
admet-544	377	3	hplc	hplc	NOUN
admet-544	377	4	method	method	NOUN
admet-544	377	5	to	to	PART
admet-544	377	6	determine	determine	VERB
admet-544	377	7	compounds	compound	NOUN
admet-544	377	8	binding	bind	VERB
admet-544	377	9	to	to	ADP
admet-544	377	10	human	human	ADJ
admet-544	377	11	serum	serum	NOUN
admet-544	377	12	albumin	albumin	NOUN
admet-544	377	13	.	.	PUNCT
admet-544	378	1	relationships	relationship	NOUN
admet-544	378	2	with	with	ADP
admet-544	378	3	octanol	octanol	NOUN
admet-544	378	4	/	/	SYM
admet-544	378	5	water	water	NOUN
admet-544	378	6	and	and	CCONJ
admet-544	378	7	immobilized	immobilize	VERB
admet-544	378	8	artificial	artificial	ADJ
admet-544	378	9	membrane	membrane	NOUN
admet-544	378	10	lipophilicity	lipophilicity	NOUN
admet-544	378	11	.	.	PUNCT
admet-544	379	1	j.	j.	PROPN
admet-544	379	2	pharm	pharm	PROPN
admet-544	379	3	.	.	PUNCT
admet-544	380	1	sci	sci	PROPN
admet-544	380	2	.	.	PROPN
admet-544	381	1	92	92	NUM
admet-544	381	2	(	(	PUNCT
admet-544	381	3	2003	2003	NUM
admet-544	381	4	)	)	PUNCT
admet-544	381	5	2236	2236	NUM
admet-544	381	6	-	-	SYM
admet-544	381	7	2248	2248	NUM
admet-544	381	8	.	.	PUNCT
admet-544	382	1	[	[	X
admet-544	382	2	35	35	NUM
admet-544	382	3	]	]	X
admet-544	382	4	l.j	l.j	PROPN
admet-544	382	5	.	.	PROPN
admet-544	382	6	gordon	gordon	PROPN
admet-544	382	7	.	.	PUNCT
admet-544	383	1	m.	m.	PROPN
admet-544	383	2	allen	allen	PROPN
admet-544	383	3	,	,	PUNCT
admet-544	383	4	p.	p.	PROPN
admet-544	383	5	artursson	artursson	PROPN
admet-544	383	6	,	,	PUNCT
admet-544	383	7	m.m	m.m	PROPN
admet-544	383	8	.	.	PROPN
admet-544	383	9	hann	hann	PROPN
admet-544	383	10	,	,	PUNCT
admet-544	383	11	b.j	b.j	PROPN
admet-544	383	12	.	.	PROPN
admet-544	383	13	leavens	leaven	VERB
admet-544	383	14	,	,	PUNCT
admet-544	383	15	a.	a.	NOUN
admet-544	383	16	mateus	mateus	PROPN
admet-544	383	17	,	,	PUNCT
admet-544	383	18	s.	s.	PROPN
admet-544	383	19	readshaw	readshaw	PROPN
admet-544	383	20	,	,	PUNCT
admet-544	383	21	k.	k.	PROPN
admet-544	383	22	valko	valko	PROPN
admet-544	383	23	,	,	PUNCT
admet-544	383	24	g.j	g.j	PROPN
admet-544	383	25	.	.	PROPN
admet-544	383	26	wayne	wayne	PROPN
admet-544	383	27	,	,	PUNCT
admet-544	383	28	a.	a.	PROPN
admet-544	383	29	west	west	PROPN
admet-544	383	30	.	.	PUNCT
admet-544	384	1	direct	direct	ADJ
admet-544	384	2	measurement	measurement	NOUN
admet-544	384	3	of	of	ADP
admet-544	384	4	intracellular	intracellular	ADJ
admet-544	384	5	compound	compound	NOUN
admet-544	384	6	concentration	concentration	NOUN
admet-544	384	7	by	by	ADP
admet-544	384	8	rapidfire	rapidfire	NOUN
admet-544	384	9	mass	mass	PROPN
admet-544	384	10	spectrometry	spectrometry	NOUN
admet-544	384	11	offers	offer	VERB
admet-544	384	12	insights	insight	NOUN
admet-544	384	13	into	into	ADP
admet-544	384	14	cell	cell	NOUN
admet-544	384	15	permeability	permeability	NOUN
admet-544	384	16	.	.	PUNCT
admet-544	385	1	j.	j.	PROPN
admet-544	385	2	biomol	biomol	PROPN
admet-544	385	3	.	.	PUNCT
admet-544	386	1	screen	screen	NOUN
admet-544	386	2	.	.	PUNCT
admet-544	387	1	21	21	NUM
admet-544	387	2	(	(	PUNCT
admet-544	387	3	2016	2016	NUM
admet-544	387	4	)	)	PUNCT
admet-544	387	5	156	156	NUM
admet-544	387	6	-	-	SYM
admet-544	387	7	164	164	NUM
admet-544	387	8	.	.	PUNCT
admet-544	388	1	[	[	X
admet-544	388	2	36	36	NUM
admet-544	388	3	]	]	PUNCT
admet-544	388	4	k.	k.	PROPN
admet-544	388	5	valko	valko	PROPN
admet-544	388	6	,	,	PUNCT
admet-544	388	7	physicochemical	physicochemical	ADJ
admet-544	388	8	and	and	CCONJ
admet-544	388	9	biomimetic	biomimetic	ADJ
admet-544	388	10	properties	property	NOUN
admet-544	388	11	in	in	ADP
admet-544	388	12	drug	drug	NOUN
admet-544	388	13	discovery	discovery	NOUN
admet-544	388	14	chromatographic	chromatographic	ADJ
admet-544	388	15	techniques	technique	NOUN
admet-544	388	16	for	for	ADP
admet-544	388	17	lead	lead	ADJ
admet-544	388	18	optimization	optimization	NOUN
admet-544	388	19	.	.	PUNCT
admet-544	389	1	wiley	wiley	PROPN
admet-544	389	2	,	,	PUNCT
admet-544	389	3	hoboken	hoboken	PROPN
admet-544	389	4	,	,	PUNCT
admet-544	389	5	nj	nj	PROPN
admet-544	389	6	(	(	PUNCT
admet-544	389	7	2014	2014	NUM
admet-544	389	8	)	)	PUNCT
admet-544	389	9	.	.	PUNCT
admet-544	390	1	[	[	X
admet-544	390	2	37	37	NUM
admet-544	390	3	]	]	PUNCT
admet-544	390	4	i.	i.	NOUN
admet-544	390	5	canals	canal	NOUN
admet-544	390	6	,	,	PUNCT
admet-544	390	7	k.	k.	PROPN
admet-544	390	8	valkó	valkó	PROPN
admet-544	390	9	,	,	PUNCT
admet-544	390	10	e.	e.	PROPN
admet-544	390	11	bosch	bosch	PROPN
admet-544	390	12	,	,	PUNCT
admet-544	390	13	a.p	a.p	PROPN
admet-544	390	14	.	.	PROPN
admet-544	390	15	hill	hill	PROPN
admet-544	390	16	,	,	PUNCT
admet-544	390	17	m.	m.	NOUN
admet-544	390	18	rosés	rosés	PROPN
admet-544	390	19	.	.	PUNCT
admet-544	391	1	retention	retention	NOUN
admet-544	391	2	of	of	ADP
admet-544	391	3	ionizable	ionizable	ADJ
admet-544	391	4	compounds	compound	NOUN
admet-544	391	5	on	on	ADP
admet-544	391	6	hplc	hplc	NOUN
admet-544	391	7	.	.	PUNCT
admet-544	392	1	8	8	X
admet-544	392	2	.	.	X
admet-544	392	3	influence	influence	NOUN
admet-544	392	4	of	of	ADP
admet-544	392	5	mobile	mobile	ADJ
admet-544	392	6	-	-	PUNCT
admet-544	392	7	phase	phase	NOUN
admet-544	392	8	ph	ph	NOUN
admet-544	392	9	change	change	NOUN
admet-544	392	10	on	on	ADP
admet-544	392	11	the	the	DET
admet-544	392	12	chromatographic	chromatographic	ADJ
admet-544	392	13	retention	retention	NOUN
admet-544	392	14	of	of	ADP
admet-544	392	15	acids	acid	NOUN
admet-544	392	16	and	and	CCONJ
admet-544	392	17	bases	basis	NOUN
admet-544	392	18	during	during	ADP
admet-544	392	19	gradient	gradient	ADJ
admet-544	392	20	elution	elution	NOUN
admet-544	392	21	.	.	PUNCT
admet-544	393	1	anal	anal	PROPN
admet-544	393	2	.	.	PUNCT
admet-544	393	3	chem	chem	PROPN
admet-544	393	4	.	.	PUNCT
admet-544	394	1	73	73	NUM
admet-544	394	2	(	(	PUNCT
admet-544	394	3	2001	2001	NUM
admet-544	394	4	)	)	PUNCT
admet-544	394	5	4937–4945	4937–4945	NUM
admet-544	394	6	.	.	PUNCT
admet-544	395	1	[	[	X
admet-544	395	2	38	38	NUM
admet-544	395	3	]	]	X
admet-544	395	4	k.l	k.l	PROPN
admet-544	395	5	.	.	PROPN
admet-544	395	6	valkó	valkó	PROPN
admet-544	395	7	,	,	PUNCT
admet-544	395	8	s.b	s.b	PROPN
admet-544	395	9	.	.	PROPN
admet-544	395	10	nunhuck	nunhuck	PROPN
admet-544	395	11	,	,	PUNCT
admet-544	395	12	a.p	a.p	PROPN
admet-544	395	13	.	.	PROPN
admet-544	395	14	hill	hill	PROPN
admet-544	395	15	.	.	PUNCT
admet-544	396	1	estimating	estimate	VERB
admet-544	396	2	unbound	unbound	NOUN
admet-544	396	3	volume	volume	NOUN
admet-544	396	4	of	of	ADP
admet-544	396	5	distribution	distribution	NOUN
admet-544	396	6	and	and	CCONJ
admet-544	396	7	tissue	tissue	NOUN
admet-544	396	8	binding	bind	VERB
admet-544	396	9	by	by	ADP
admet-544	396	10	in	in	ADP
admet-544	396	11	vitro	vitro	X
admet-544	396	12	hplc	hplc	NOUN
admet-544	396	13	-	-	PUNCT
admet-544	396	14	based	base	VERB
admet-544	396	15	human	human	ADJ
admet-544	396	16	serum	serum	NOUN
admet-544	396	17	albumin	albumin	NOUN
admet-544	396	18	and	and	CCONJ
admet-544	396	19	immobilized	immobilize	VERB
admet-544	396	20	artificial	artificial	ADJ
admet-544	396	21	artificial	artificial	ADJ
admet-544	396	22	membrane	membrane	NOUN
admet-544	396	23	-	-	PUNCT
admet-544	396	24	binding	bind	VERB
admet-544	396	25	measurements	measurement	NOUN
admet-544	396	26	.	.	PUNCT
admet-544	397	1	j.	j.	PROPN
admet-544	397	2	pharm	pharm	PROPN
admet-544	397	3	.	.	PUNCT
admet-544	398	1	sci	sci	PROPN
admet-544	398	2	.	.	PROPN
admet-544	398	3	100	100	NUM
admet-544	398	4	(	(	PUNCT
admet-544	398	5	2011	2011	NUM
admet-544	398	6	)	)	PUNCT
admet-544	398	7	849–862	849–862	NUM
admet-544	398	8	.	.	PUNCT
admet-544	399	1	[	[	X
admet-544	399	2	39	39	NUM
admet-544	399	3	]	]	PUNCT
admet-544	399	4	k.	k.	PROPN
admet-544	399	5	valko	valko	PROPN
admet-544	399	6	,	,	PUNCT
admet-544	399	7	e.	e.	PROPN
admet-544	399	8	chiarparin	chiarparin	PROPN
admet-544	399	9	,	,	PUNCT
admet-544	399	10	s.	s.	PROPN
admet-544	399	11	nunhuck	nunhuck	PROPN
admet-544	399	12	,	,	PUNCT
admet-544	399	13	d.	d.	PROPN
admet-544	399	14	montanari	montanari	PROPN
admet-544	399	15	.	.	PUNCT
admet-544	400	1	in	in	ADP
admet-544	400	2	vitro	vitro	X
admet-544	400	3	measurement	measurement	NOUN
admet-544	400	4	of	of	ADP
admet-544	400	5	drug	drug	NOUN
admet-544	400	6	efficiency	efficiency	NOUN
admet-544	400	7	index	index	NOUN
admet-544	400	8	to	to	PART
admet-544	400	9	aid	aid	VERB
admet-544	400	10	early	early	ADJ
admet-544	400	11	lead	lead	ADJ
admet-544	400	12	optimization	optimization	NOUN
admet-544	400	13	.	.	PUNCT
admet-544	401	1	j.	j.	PROPN
admet-544	401	2	pharm	pharm	PROPN
admet-544	401	3	.	.	PUNCT
admet-544	402	1	sci	sci	PROPN
admet-544	402	2	.	.	PROPN
admet-544	403	1	101	101	NUM
admet-544	403	2	(	(	PUNCT
admet-544	403	3	2012	2012	NUM
admet-544	403	4	)	)	PUNCT
admet-544	403	5	4155	4155	NUM
admet-544	403	6	-	-	SYM
admet-544	403	7	4169	4169	NUM
admet-544	403	8	.	.	PUNCT
admet-544	404	1	[	[	X
admet-544	404	2	40	40	NUM
admet-544	404	3	]	]	PUNCT
admet-544	404	4	b.	b.	PROPN
admet-544	404	5	i.	i.	PROPN
admet-544	404	6	díaz	díaz	PROPN
admet-544	404	7	-	-	PUNCT
admet-544	404	8	eufracio	eufracio	NOUN
admet-544	404	9	,	,	PUNCT
admet-544	404	10	o.	o.	PROPN
admet-544	404	11	palomino	palomino	PROPN
admet-544	404	12	-	-	PUNCT
admet-544	404	13	hernández	hernández	PROPN
admet-544	404	14	,	,	PUNCT
admet-544	404	15	r.	r.	PROPN
admet-544	404	16	a.	a.	PROPN
admet-544	404	17	houghten	houghten	PROPN
admet-544	404	18	,	,	PUNCT
admet-544	404	19	j.l	j.l	PROPN
admet-544	404	20	.	.	PROPN
admet-544	404	21	medina	medina	PROPN
admet-544	404	22	-	-	PUNCT
admet-544	404	23	franco	franco	PROPN
admet-544	404	24	.	.	PUNCT
admet-544	405	1	exploring	explore	VERB
admet-544	405	2	the	the	DET
admet-544	405	3	chemical	chemical	ADJ
admet-544	405	4	space	space	NOUN
admet-544	405	5	of	of	ADP
admet-544	405	6	peptides	peptide	NOUN
admet-544	405	7	for	for	ADP
admet-544	405	8	drug	drug	NOUN
admet-544	405	9	discovery	discovery	NOUN
admet-544	405	10	:	:	PUNCT
admet-544	405	11	a	a	DET
admet-544	405	12	focus	focus	NOUN
admet-544	405	13	on	on	ADP
admet-544	405	14	linear	linear	ADJ
admet-544	405	15	and	and	CCONJ
admet-544	405	16	cyclic	cyclic	ADJ
admet-544	405	17	penta	penta	NOUN
admet-544	405	18	-	-	PUNCT
admet-544	405	19	peptides	peptide	NOUN
admet-544	405	20	.	.	PUNCT
admet-544	406	1	mol	mol	PROPN
admet-544	406	2	.	.	PUNCT
admet-544	407	1	divers	divers	PROPN
admet-544	407	2	.	.	PUNCT
admet-544	408	1	(	(	PUNCT
admet-544	408	2	2018	2018	NUM
admet-544	408	3	)	)	PUNCT
admet-544	408	4	doi	doi	NOUN
admet-544	408	5	:	:	PUNCT
admet-544	408	6	10.1007	10.1007	NUM
admet-544	408	7	/	/	SYM
admet-544	408	8	s11030	s11030	PROPN
admet-544	408	9	-	-	PUNCT
admet-544	408	10	018	018	NUM
admet-544	408	11	-	-	PUNCT
admet-544	408	12	9812	9812	NUM
admet-544	408	13	-	-	PUNCT
admet-544	408	14	9	9	NUM
admet-544	408	15	.	.	PUNCT
admet-544	409	1	[	[	X
admet-544	409	2	41	41	NUM
admet-544	409	3	]	]	PUNCT
admet-544	409	4	v.	v.	ADP
admet-544	409	5	stepanić	stepanić	PROPN
admet-544	409	6	,	,	PUNCT
admet-544	409	7	d.	d.	PROPN
admet-544	409	8	žiher	žiher	PROPN
admet-544	409	9	,	,	PUNCT
admet-544	409	10	v.	v.	ADP
admet-544	409	11	gabelica	gabelica	NOUN
admet-544	409	12	-	-	PUNCT
admet-544	409	13	marković	marković	NOUN
admet-544	409	14	,	,	PUNCT
admet-544	409	15	d.	d.	PROPN
admet-544	409	16	jelić	jelić	PROPN
admet-544	409	17	,	,	PUNCT
admet-544	409	18	s.	s.	PROPN
admet-544	409	19	nunhuck	nunhuck	PROPN
admet-544	409	20	,	,	PUNCT
admet-544	409	21	k.	k.	PROPN
admet-544	409	22	valko	valko	PROPN
admet-544	409	23	,	,	PUNCT
admet-544	409	24	s.	s.	PROPN
admet-544	409	25	koštrun	koštrun	PROPN
admet-544	409	26	..	..	PUNCT
admet-544	409	27	physicochemical	physicochemical	ADJ
admet-544	409	28	profile	profile	NOUN
admet-544	409	29	of	of	ADP
admet-544	409	30	macrolides	macrolide	NOUN
admet-544	409	31	and	and	CCONJ
admet-544	409	32	their	their	PRON
admet-544	409	33	comparison	comparison	NOUN
admet-544	409	34	with	with	ADP
admet-544	409	35	small	small	ADJ
admet-544	409	36	molecules	molecule	NOUN
admet-544	409	37	.	.	PUNCT
admet-544	410	1	eur	eur	PROPN
admet-544	410	2	.	.	PUNCT
admet-544	411	1	j.	j.	PROPN
admet-544	411	2	med	med	PROPN
admet-544	411	3	.	.	PROPN
admet-544	411	4	chem	chem	PROPN
admet-544	411	5	.	.	PUNCT
admet-544	412	1	47	47	NUM
admet-544	412	2	(	(	PUNCT
admet-544	412	3	2012	2012	NUM
admet-544	412	4	)	)	PUNCT
admet-544	412	5	462–472	462–472	NUM
admet-544	412	6	.	.	PUNCT
admet-544	413	1	[	[	X
admet-544	413	2	42	42	NUM
admet-544	413	3	]	]	PUNCT
admet-544	413	4	k.	k.	PROPN
admet-544	413	5	valko	valko	PROPN
admet-544	413	6	,	,	PUNCT
admet-544	413	7	m.	m.	NOUN
admet-544	413	8	kindy	kindy	PROPN
admet-544	413	9	,	,	PUNCT
admet-544	413	10	j.	j.	PROPN
admet-544	413	11	evans	evans	PROPN
admet-544	413	12	,	,	PUNCT
admet-544	413	13	d.	d.	PROPN
admet-544	413	14	ko	ko	PROPN
admet-544	413	15	.	.	PUNCT
admet-544	414	1	in	in	ADP
admet-544	414	2	vitro	vitro	X
admet-544	414	3	and	and	CCONJ
admet-544	414	4	in	in	ADP
admet-544	414	5	vivo	vivo	ADJ
admet-544	414	6	characterization	characterization	NOUN
admet-544	414	7	of	of	ADP
admet-544	414	8	gm6	gm6	PROPN
admet-544	414	9	an	an	DET
admet-544	414	10	endogenous	endogenous	ADJ
admet-544	414	11	regulator	regulator	NOUN
admet-544	414	12	peptide	peptide	NOUN
admet-544	414	13	drug	drug	NOUN
admet-544	414	14	candidate	candidate	NOUN
admet-544	414	15	for	for	ADP
admet-544	414	16	amyotrophic	amyotrophic	ADJ
admet-544	414	17	lateral	lateral	ADJ
admet-544	414	18	sclerosis	sclerosis	NOUN
admet-544	414	19	(	(	PUNCT
admet-544	414	20	als	als	NOUN
admet-544	414	21	)	)	PUNCT
admet-544	414	22	.	.	PUNCT
admet-544	415	1	admet	admet	PROPN
admet-544	415	2	dmpk	dmpk	PROPN
admet-544	415	3	(	(	PUNCT
admet-544	415	4	2018	2018	NUM
admet-544	415	5	)	)	PUNCT
admet-544	415	6	doi	doi	NOUN
admet-544	415	7	:	:	PUNCT
admet-544	415	8	http://dx.doi.org/10.5599/admet.547	http://dx.doi.org/10.5599/admet.547	NOUN
admet-544	415	9	.	.	PUNCT
admet-544	416	1	©	©	PROPN
admet-544	416	2	2018	2018	NUM
admet-544	416	3	by	by	ADP
admet-544	416	4	the	the	DET
admet-544	416	5	authors	author	NOUN
admet-544	416	6	;	;	PUNCT
admet-544	416	7	licensee	licensee	PROPN
admet-544	416	8	iapc	iapc	PROPN
admet-544	416	9	,	,	PUNCT
admet-544	416	10	zagreb	zagreb	PROPN
admet-544	416	11	,	,	PUNCT
admet-544	416	12	croatia	croatia	PROPN
admet-544	416	13	.	.	PUNCT
admet-544	417	1	this	this	DET
admet-544	417	2	article	article	NOUN
admet-544	417	3	is	be	AUX
admet-544	417	4	an	an	DET
admet-544	417	5	open	open	ADJ
admet-544	417	6	-	-	PUNCT
admet-544	417	7	access	access	NOUN
admet-544	417	8	article	article	NOUN
admet-544	417	9	distributed	distribute	VERB
admet-544	417	10	under	under	ADP
admet-544	417	11	the	the	DET
admet-544	417	12	terms	term	NOUN
admet-544	417	13	and	and	CCONJ
admet-544	417	14	conditions	condition	NOUN
admet-544	417	15	of	of	ADP
admet-544	417	16	the	the	DET
admet-544	417	17	creative	creative	ADJ
admet-544	417	18	commons	common	NOUN
admet-544	417	19	attribution	attribution	NOUN
admet-544	417	20	license	license	NOUN
admet-544	417	21	(	(	PUNCT
admet-544	417	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-544	417	23	)	)	PUNCT
admet-544	417	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN