id	sid	tid	token	lemma	pos
admet-547	1	1	in	in	ADP
admet-547	1	2	vitro	vitro	X
admet-547	1	3	biomimetic	biomimetic	ADJ
admet-547	1	4	hplc	hplc	NOUN
admet-547	1	5	and	and	CCONJ
admet-547	1	6	in	in	ADP
admet-547	1	7	vivo	vivo	ADJ
admet-547	1	8	characterisation	characterisation	NOUN
admet-547	1	9	of	of	ADP
admet-547	1	10	gm6	gm6	PROPN
admet-547	1	11	,	,	PUNCT
admet-547	1	12	an	an	DET
admet-547	1	13	endogenous	endogenous	ADJ
admet-547	1	14	regulator	regulator	NOUN
admet-547	1	15	peptide	peptide	NOUN
admet-547	1	16	drug	drug	NOUN
admet-547	1	17	candidate	candidate	NOUN
admet-547	1	18	for	for	ADP
admet-547	1	19	amyotrophic	amyotrophic	ADJ
admet-547	1	20	lateral	lateral	ADJ
admet-547	1	21	sclerosis	sclerosis	NOUN
admet-547	1	22	doi	doi	PROPN
admet-547	1	23	:	:	PUNCT
admet-547	1	24	10.5599	10.5599	NUM
admet-547	1	25	/	/	SYM
admet-547	1	26	admet.547	admet.547	NOUN
admet-547	1	27	176	176	NUM
admet-547	1	28	admet	admet	NOUN
admet-547	1	29	&	&	CCONJ
admet-547	1	30	dmpk	dmpk	PROPN
admet-547	1	31	6(2	6(2	NUM
admet-547	1	32	)	)	PUNCT
admet-547	1	33	(	(	PUNCT
admet-547	1	34	2018	2018	NUM
admet-547	1	35	)	)	PUNCT
admet-547	1	36	176	176	NUM
admet-547	1	37	-	-	SYM
admet-547	1	38	189	189	NUM
admet-547	1	39	;	;	PUNCT
admet-547	1	40	doi	doi	NOUN
admet-547	1	41	:	:	PUNCT
admet-547	1	42	http://dx.doi.org/10.5599/admet.547	http://dx.doi.org/10.5599/admet.547	NOUN
admet-547	1	43	open	open	ADJ
admet-547	1	44	access	access	NOUN
admet-547	1	45	:	:	PUNCT
admet-547	1	46	issn	issn	PROPN
admet-547	1	47	:	:	PUNCT
admet-547	1	48	1848	1848	NUM
admet-547	1	49	-	-	SYM
admet-547	1	50	7718	7718	NUM
admet-547	1	51	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-547	1	52	original	original	ADJ
admet-547	1	53	scientific	scientific	ADJ
admet-547	1	54	paper	paper	NOUN
admet-547	1	55	in	in	ADP
admet-547	1	56	vitro	vitro	X
admet-547	1	57	biomimetic	biomimetic	ADJ
admet-547	1	58	hplc	hplc	NOUN
admet-547	1	59	and	and	CCONJ
admet-547	1	60	in	in	ADP
admet-547	1	61	vivo	vivo	ADJ
admet-547	1	62	characterisation	characterisation	NOUN
admet-547	1	63	of	of	ADP
admet-547	1	64	gm6	gm6	PROPN
admet-547	1	65	,	,	PUNCT
admet-547	1	66	an	an	DET
admet-547	1	67	endogenous	endogenous	ADJ
admet-547	1	68	regulator	regulator	NOUN
admet-547	1	69	peptide	peptide	NOUN
admet-547	1	70	drug	drug	NOUN
admet-547	1	71	candidate	candidate	NOUN
admet-547	1	72	for	for	ADP
admet-547	1	73	amyotrophic	amyotrophic	ADJ
admet-547	1	74	lateral	lateral	ADJ
admet-547	1	75	sclerosis	sclerosis	NOUN
admet-547	1	76	klara	klara	PROPN
admet-547	1	77	valko*1,2	valko*1,2	PROPN
admet-547	1	78	,	,	PUNCT
admet-547	1	79	mark	mark	PROPN
admet-547	1	80	kindy3,4	kindy3,4	PROPN
admet-547	1	81	,	,	PUNCT
admet-547	1	82	james	james	PROPN
admet-547	1	83	evans5	evans5	PROPN
admet-547	1	84	,	,	PUNCT
admet-547	1	85	dorothy	dorothy	PROPN
admet-547	1	86	ko6	ko6	PROPN
admet-547	1	87	1	1	NUM
admet-547	1	88	bio	bio	ADJ
admet-547	1	89	-	-	ADJ
admet-547	1	90	mimetic	mimetic	ADJ
admet-547	1	91	chromatography	chromatography	PROPN
admet-547	1	92	ltd	ltd	PROPN
admet-547	1	93	,	,	PUNCT
admet-547	1	94	business	business	PROPN
admet-547	1	95	&	&	CCONJ
admet-547	1	96	technology	technology	PROPN
admet-547	1	97	centre	centre	PROPN
admet-547	1	98	,	,	PUNCT
admet-547	1	99	stevenage	stevenage	PROPN
admet-547	1	100	,	,	PUNCT
admet-547	1	101	sg1	sg1	PROPN
admet-547	1	102	2dx	2dx	PROPN
admet-547	1	103	united	united	PROPN
admet-547	1	104	kingdom	kingdom	PROPN
admet-547	1	105	2	2	NUM
admet-547	1	106	department	department	NOUN
admet-547	1	107	of	of	ADP
admet-547	1	108	biological	biological	ADJ
admet-547	1	109	and	and	CCONJ
admet-547	1	110	pharmaceutical	pharmaceutical	NOUN
admet-547	1	111	chemistry	chemistry	NOUN
admet-547	1	112	,	,	PUNCT
admet-547	1	113	ucl	ucl	VERB
admet-547	1	114	school	school	NOUN
admet-547	1	115	of	of	ADP
admet-547	1	116	pharmacy	pharmacy	NOUN
admet-547	1	117	london	london	PROPN
admet-547	1	118	wc1n	wc1n	PROPN
admet-547	1	119	1ax	1ax	ADJ
admet-547	1	120	united	united	ADJ
admet-547	1	121	kingdom	kingdom	PROPN
admet-547	1	122	3	3	NUM
admet-547	1	123	department	department	NOUN
admet-547	1	124	of	of	ADP
admet-547	1	125	pharmaceutical	pharmaceutical	NOUN
admet-547	1	126	sciences	science	NOUN
admet-547	1	127	,	,	PUNCT
admet-547	1	128	college	college	NOUN
admet-547	1	129	of	of	ADP
admet-547	1	130	pharmacy	pharmacy	NOUN
admet-547	1	131	,	,	PUNCT
admet-547	1	132	university	university	NOUN
admet-547	1	133	of	of	ADP
admet-547	1	134	south	south	PROPN
admet-547	1	135	florida	florida	PROPN
admet-547	1	136	,	,	PUNCT
admet-547	1	137	tampa	tampa	PROPN
admet-547	1	138	,	,	PUNCT
admet-547	1	139	fl	fl	PROPN
admet-547	1	140	,	,	PUNCT
admet-547	1	141	usa	usa	PROPN
admet-547	1	142	.	.	PROPN
admet-547	1	143	4	4	NUM
admet-547	1	144	james	james	PROPN
admet-547	1	145	a.	a.	PROPN
admet-547	1	146	haley	haley	PROPN
admet-547	1	147	vamc	vamc	PROPN
admet-547	1	148	,	,	PUNCT
admet-547	1	149	tampa	tampa	PROPN
admet-547	1	150	,	,	PUNCT
admet-547	1	151	fl	fl	PROPN
admet-547	1	152	,	,	PUNCT
admet-547	1	153	usa	usa	PROPN
admet-547	1	154	.	.	PROPN
admet-547	1	155	5	5	NUM
admet-547	1	156	phenovista	phenovista	NOUN
admet-547	1	157	,	,	PUNCT
admet-547	1	158	san	san	PROPN
admet-547	1	159	diego	diego	PROPN
admet-547	1	160	,	,	PUNCT
admet-547	1	161	ca	ca	PROPN
admet-547	1	162	,	,	PUNCT
admet-547	1	163	usa	usa	PROPN
admet-547	1	164	6	6	NUM
admet-547	1	165	genervon	genervon	PROPN
admet-547	1	166	biopharmaceuticals	biopharmaceutical	NOUN
admet-547	1	167	llc	llc	PROPN
admet-547	1	168	,	,	PUNCT
admet-547	1	169	pasadena	pasadena	PROPN
admet-547	1	170	,	,	PUNCT
admet-547	1	171	ca	ca	PROPN
admet-547	1	172	,	,	PUNCT
admet-547	1	173	usa	usa	PROPN
admet-547	1	174	*	*	PUNCT
admet-547	1	175	corresponding	correspond	VERB
admet-547	1	176	author	author	NOUN
admet-547	1	177	e	e	NOUN
admet-547	1	178	-	-	NOUN
admet-547	1	179	mail	mail	NOUN
admet-547	1	180	:	:	PUNCT
admet-547	1	181	k.valko@ucl.ac.uk	k.valko@ucl.ac.uk	ADJ
admet-547	1	182	and	and	CCONJ
admet-547	1	183	klara_valko@bio-mimetic-chromatography.com	klara_valko@bio-mimetic-chromatography.com	NOUN
admet-547	1	184	;	;	PUNCT
admet-547	1	185	tel	tel	PROPN
admet-547	1	186	.	.	PUNCT
admet-547	1	187	:	:	PUNCT
admet-547	2	1	+44	+44	PROPN
admet-547	2	2	7521	7521	NUM
admet-547	2	3	989558	989558	NUM
admet-547	2	4	received	receive	VERB
admet-547	2	5	:	:	PUNCT
admet-547	2	6	may	may	AUX
admet-547	2	7	08	08	NUM
admet-547	2	8	,	,	PUNCT
admet-547	2	9	2018	2018	NUM
admet-547	2	10	;	;	PUNCT
admet-547	2	11	revised	revise	VERB
admet-547	2	12	:	:	PUNCT
admet-547	2	13	may	may	AUX
admet-547	2	14	28	28	NUM
admet-547	2	15	,	,	PUNCT
admet-547	2	16	2018	2018	NUM
admet-547	2	17	;	;	PUNCT
admet-547	2	18	published	publish	VERB
admet-547	2	19	:	:	PUNCT
admet-547	2	20	june	june	PROPN
admet-547	2	21	16	16	NUM
admet-547	2	22	,	,	PUNCT
admet-547	2	23	2018	2018	NUM
admet-547	2	24	abstract	abstract	ADJ
admet-547	2	25	amyotrophic	amyotrophic	ADJ
admet-547	2	26	lateral	lateral	ADJ
admet-547	2	27	sclerosis	sclerosis	NOUN
admet-547	2	28	(	(	PUNCT
admet-547	2	29	als	als	NOUN
admet-547	2	30	)	)	PUNCT
admet-547	2	31	is	be	AUX
admet-547	2	32	an	an	DET
admet-547	2	33	idiopathic	idiopathic	ADJ
admet-547	2	34	,	,	PUNCT
admet-547	2	35	fatal	fatal	ADJ
admet-547	2	36	neurodegenerative	neurodegenerative	ADJ
admet-547	2	37	disease	disease	NOUN
admet-547	2	38	of	of	ADP
admet-547	2	39	the	the	DET
admet-547	2	40	human	human	ADJ
admet-547	2	41	motor	motor	NOUN
admet-547	2	42	system	system	NOUN
admet-547	2	43	.	.	PUNCT
admet-547	3	1	subunits	subunit	NOUN
admet-547	3	2	of	of	ADP
admet-547	3	3	the	the	DET
admet-547	3	4	33	33	NUM
admet-547	3	5	-	-	PUNCT
admet-547	3	6	amino	amino	NOUN
admet-547	3	7	acid	acid	NOUN
admet-547	3	8	containing	contain	VERB
admet-547	3	9	motorneurontrophic	motorneurontrophic	ADJ
admet-547	3	10	factor	factor	NOUN
admet-547	3	11	(	(	PUNCT
admet-547	3	12	mntf	mntf	VERB
admet-547	3	13	)	)	PUNCT
admet-547	3	14	have	have	AUX
admet-547	3	15	been	be	AUX
admet-547	3	16	investigated	investigate	VERB
admet-547	3	17	and	and	CCONJ
admet-547	3	18	gm6	gm6	PROPN
admet-547	3	19	has	have	AUX
admet-547	3	20	been	be	AUX
admet-547	3	21	found	find	VERB
admet-547	3	22	as	as	ADP
admet-547	3	23	a	a	DET
admet-547	3	24	potential	potential	ADJ
admet-547	3	25	peptide	peptide	NOUN
admet-547	3	26	therapeutic	therapeutic	ADJ
admet-547	3	27	for	for	ADP
admet-547	3	28	als	al	NOUN
admet-547	3	29	.	.	PUNCT
admet-547	4	1	this	this	DET
admet-547	4	2	linear	linear	PROPN
admet-547	4	3	peptide	peptide	NOUN
admet-547	4	4	drug	drug	NOUN
admet-547	4	5	candidate	candidate	NOUN
admet-547	4	6	has	have	AUX
admet-547	4	7	been	be	AUX
admet-547	4	8	characterized	characterize	VERB
admet-547	4	9	by	by	ADP
admet-547	4	10	hplc	hplc	NOUN
admet-547	4	11	based	base	VERB
admet-547	4	12	physicochemical	physicochemical	ADJ
admet-547	4	13	and	and	CCONJ
admet-547	4	14	biomimetic	biomimetic	ADJ
admet-547	4	15	measurements	measurement	NOUN
admet-547	4	16	to	to	PART
admet-547	4	17	estimate	estimate	VERB
admet-547	4	18	its	its	PRON
admet-547	4	19	in	in	ADP
admet-547	4	20	vivo	vivo	ADJ
admet-547	4	21	distribution	distribution	NOUN
admet-547	4	22	behavior	behavior	NOUN
admet-547	4	23	and	and	CCONJ
admet-547	4	24	to	to	PART
admet-547	4	25	estimate	estimate	VERB
admet-547	4	26	its	its	PRON
admet-547	4	27	cell	cell	NOUN
admet-547	4	28	penetration	penetration	NOUN
admet-547	4	29	and	and	CCONJ
admet-547	4	30	brain	brain	NOUN
admet-547	4	31	to	to	ADP
admet-547	4	32	plasma	plasma	NOUN
admet-547	4	33	concentration	concentration	NOUN
admet-547	4	34	ratio	ratio	NOUN
admet-547	4	35	.	.	PUNCT
admet-547	5	1	the	the	DET
admet-547	5	2	free	free	ADJ
admet-547	5	3	tissue	tissue	NOUN
admet-547	5	4	concentration	concentration	NOUN
admet-547	5	5	vs	vs	ADP
admet-547	5	6	time	time	NOUN
admet-547	5	7	profile	profile	NOUN
admet-547	5	8	has	have	AUX
admet-547	5	9	been	be	AUX
admet-547	5	10	estimated	estimate	VERB
admet-547	5	11	using	use	VERB
admet-547	5	12	the	the	DET
admet-547	5	13	measured	measure	VERB
admet-547	5	14	physicochemical	physicochemical	ADJ
admet-547	5	15	and	and	CCONJ
admet-547	5	16	biomimetic	biomimetic	ADJ
admet-547	5	17	properties	property	NOUN
admet-547	5	18	of	of	ADP
admet-547	5	19	the	the	DET
admet-547	5	20	intact	intact	ADJ
admet-547	5	21	gm6	gm6	PROPN
admet-547	5	22	molecules	molecule	NOUN
admet-547	5	23	and	and	CCONJ
admet-547	5	24	its	its	PRON
admet-547	5	25	microsomal	microsomal	ADJ
admet-547	5	26	stability	stability	NOUN
admet-547	5	27	.	.	PUNCT
admet-547	6	1	the	the	DET
admet-547	6	2	in	in	ADP
admet-547	6	3	vitro	vitro	X
admet-547	6	4	and	and	CCONJ
admet-547	6	5	in	in	ADP
admet-547	6	6	vivo	vivo	ADJ
admet-547	6	7	measurements	measurement	NOUN
admet-547	6	8	supported	support	VERB
admet-547	6	9	the	the	DET
admet-547	6	10	estimated	estimate	VERB
admet-547	6	11	in	in	ADP
admet-547	6	12	vivo	vivo	ADJ
admet-547	6	13	distribution	distribution	NOUN
admet-547	6	14	behavior	behavior	NOUN
admet-547	6	15	of	of	ADP
admet-547	6	16	gm6	gm6	PROPN
admet-547	6	17	.	.	PUNCT
admet-547	7	1	keywords	keyword	VERB
admet-547	7	2	motoneuron	motoneuron	NOUN
admet-547	7	3	degeneration	degeneration	NOUN
admet-547	7	4	;	;	PUNCT
admet-547	7	5	peptide	peptide	ADJ
admet-547	7	6	drug	drug	NOUN
admet-547	7	7	candidate	candidate	NOUN
admet-547	7	8	;	;	PUNCT
admet-547	7	9	adme	adme	NOUN
admet-547	7	10	of	of	ADP
admet-547	7	11	peptide	peptide	ADJ
admet-547	7	12	drugs	drug	NOUN
admet-547	7	13	;	;	PUNCT
admet-547	7	14	biomimetic	biomimetic	ADJ
admet-547	7	15	properties	property	NOUN
admet-547	7	16	;	;	PUNCT
admet-547	7	17	pk	pk	NOUN
admet-547	7	18	profile	profile	NOUN
admet-547	7	19	;	;	PUNCT
admet-547	7	20	free	free	ADJ
admet-547	7	21	tissue	tissue	NOUN
admet-547	7	22	concentration	concentration	NOUN
admet-547	7	23	vs	vs	ADP
admet-547	7	24	time	time	NOUN
admet-547	7	25	pk	pk	NOUN
admet-547	7	26	introduction	introduction	NOUN
admet-547	7	27	amyotrophic	amyotrophic	ADJ
admet-547	7	28	lateral	lateral	ADJ
admet-547	7	29	sclerosis	sclerosis	NOUN
admet-547	7	30	(	(	PUNCT
admet-547	7	31	als	als	NOUN
admet-547	7	32	)	)	PUNCT
admet-547	7	33	is	be	AUX
admet-547	7	34	an	an	DET
admet-547	7	35	idiopathic	idiopathic	ADJ
admet-547	7	36	,	,	PUNCT
admet-547	7	37	fatal	fatal	ADJ
admet-547	7	38	neurodegenerative	neurodegenerative	ADJ
admet-547	7	39	disease	disease	NOUN
admet-547	7	40	of	of	ADP
admet-547	7	41	the	the	DET
admet-547	7	42	human	human	ADJ
admet-547	7	43	motor	motor	NOUN
admet-547	7	44	system	system	NOUN
admet-547	7	45	.	.	PUNCT
admet-547	8	1	it	it	PRON
admet-547	8	2	is	be	AUX
admet-547	8	3	the	the	DET
admet-547	8	4	most	most	ADV
admet-547	8	5	common	common	ADJ
admet-547	8	6	motoneuron	motoneuron	NOUN
admet-547	8	7	disease	disease	NOUN
admet-547	8	8	in	in	ADP
admet-547	8	9	human	human	NOUN
admet-547	8	10	affecting	affect	VERB
admet-547	8	11	approximately	approximately	ADV
admet-547	8	12	2	2	NUM
admet-547	8	13	people	people	NOUN
admet-547	8	14	in	in	ADP
admet-547	8	15	100,000	100,000	NUM
admet-547	8	16	in	in	ADP
admet-547	8	17	both	both	CCONJ
admet-547	8	18	the	the	DET
admet-547	8	19	us	us	PROPN
admet-547	8	20	and	and	CCONJ
admet-547	8	21	europe	europe	PROPN
admet-547	8	22	and	and	CCONJ
admet-547	8	23	therefore	therefore	ADV
admet-547	8	24	it	it	PRON
admet-547	8	25	is	be	AUX
admet-547	8	26	considered	consider	VERB
admet-547	8	27	as	as	ADP
admet-547	8	28	a	a	DET
admet-547	8	29	rare	rare	ADJ
admet-547	8	30	orphan	orphan	NOUN
admet-547	8	31	disease	disease	NOUN
admet-547	9	1	[	[	X
admet-547	9	2	1	1	NUM
admet-547	9	3	]	]	PUNCT
admet-547	9	4	.	.	PUNCT
admet-547	10	1	als	als	NOUN
admet-547	10	2	manifests	manifest	VERB
admet-547	10	3	itself	itself	PRON
admet-547	10	4	in	in	ADP
admet-547	10	5	the	the	DET
admet-547	10	6	death	death	NOUN
admet-547	10	7	of	of	ADP
admet-547	10	8	motoneurons	motoneuron	NOUN
admet-547	10	9	which	which	PRON
admet-547	10	10	control	control	VERB
admet-547	10	11	the	the	DET
admet-547	10	12	voluntary	voluntary	ADJ
admet-547	10	13	muscles	muscle	NOUN
admet-547	10	14	.	.	PUNCT
admet-547	11	1	the	the	DET
admet-547	11	2	cause	cause	NOUN
admet-547	11	3	of	of	ADP
admet-547	11	4	als	als	NOUN
admet-547	11	5	is	be	AUX
admet-547	11	6	not	not	PART
admet-547	11	7	known	know	VERB
admet-547	11	8	in	in	ADP
admet-547	11	9	90	90	NUM
admet-547	11	10	to	to	PART
admet-547	11	11	95	95	NUM
admet-547	11	12	%	%	NOUN
admet-547	11	13	of	of	ADP
admet-547	11	14	cases	case	NOUN
admet-547	11	15	while	while	SCONJ
admet-547	11	16	familial	familial	ADJ
admet-547	11	17	inherited	inherit	VERB
admet-547	11	18	causes	cause	NOUN
admet-547	11	19	have	have	AUX
admet-547	11	20	been	be	AUX
admet-547	11	21	identified	identify	VERB
admet-547	11	22	in	in	ADP
admet-547	11	23	5	5	NUM
admet-547	11	24	to	to	PART
admet-547	11	25	10	10	NUM
admet-547	11	26	%	%	NOUN
admet-547	11	27	of	of	ADP
admet-547	11	28	cases	case	NOUN
admet-547	11	29	.	.	PUNCT
admet-547	12	1	there	there	PRON
admet-547	12	2	is	be	VERB
admet-547	12	3	no	no	DET
admet-547	12	4	cure	cure	NOUN
admet-547	12	5	for	for	ADP
admet-547	12	6	als	al	NOUN
admet-547	12	7	.	.	PUNCT
admet-547	13	1	the	the	DET
admet-547	13	2	clinical	clinical	ADJ
admet-547	13	3	onset	onset	NOUN
admet-547	13	4	of	of	ADP
admet-547	13	5	the	the	DET
admet-547	13	6	disease	disease	NOUN
admet-547	13	7	usually	usually	ADV
admet-547	13	8	starts	start	VERB
admet-547	13	9	at	at	ADP
admet-547	13	10	around	around	ADP
admet-547	13	11	age	age	NOUN
admet-547	13	12	60	60	NUM
admet-547	13	13	and	and	CCONJ
admet-547	13	14	the	the	DET
admet-547	13	15	survival	survival	NOUN
admet-547	13	16	time	time	NOUN
admet-547	13	17	is	be	AUX
admet-547	13	18	around	around	ADV
admet-547	13	19	2	2	NUM
admet-547	13	20	to	to	PART
admet-547	13	21	4	4	NUM
admet-547	13	22	years	year	NOUN
admet-547	13	23	.	.	PUNCT
admet-547	14	1	it	it	PRON
admet-547	14	2	is	be	AUX
admet-547	14	3	very	very	ADV
admet-547	14	4	difficult	difficult	ADJ
admet-547	14	5	to	to	PART
admet-547	14	6	determine	determine	VERB
admet-547	14	7	a	a	DET
admet-547	14	8	specific	specific	ADJ
admet-547	14	9	date	date	NOUN
admet-547	14	10	for	for	ADP
admet-547	14	11	the	the	DET
admet-547	14	12	onset	onset	NOUN
admet-547	14	13	of	of	ADP
admet-547	14	14	the	the	DET
admet-547	14	15	disease	disease	NOUN
admet-547	14	16	and	and	CCONJ
admet-547	14	17	the	the	DET
admet-547	14	18	potentially	potentially	ADV
admet-547	14	19	long	long	ADJ
admet-547	14	20	duration	duration	NOUN
admet-547	14	21	between	between	ADP
admet-547	14	22	the	the	DET
admet-547	14	23	onset	onset	NOUN
admet-547	14	24	of	of	ADP
admet-547	14	25	pathological	pathological	ADJ
admet-547	14	26	changes	change	NOUN
admet-547	14	27	and	and	CCONJ
admet-547	14	28	the	the	DET
admet-547	14	29	manifestation	manifestation	NOUN
admet-547	14	30	of	of	ADP
admet-547	14	31	the	the	DET
admet-547	14	32	clinical	clinical	ADJ
admet-547	14	33	disease	disease	NOUN
admet-547	14	34	.	.	PUNCT
admet-547	15	1	patients	patient	NOUN
admet-547	15	2	can	can	AUX
admet-547	15	3	present	present	VERB
admet-547	15	4	with	with	ADP
admet-547	15	5	bulbar	bulbar	ADJ
admet-547	15	6	-	-	PUNCT
admet-547	15	7	onset	onset	NOUN
admet-547	15	8	disease	disease	NOUN
admet-547	15	9	(	(	PUNCT
admet-547	15	10	about	about	ADV
admet-547	15	11	25	25	NUM
admet-547	15	12	%	%	NOUN
admet-547	15	13	)	)	PUNCT
admet-547	15	14	or	or	CCONJ
admet-547	15	15	limb	limb	NOUN
admet-547	15	16	-	-	PUNCT
admet-547	15	17	onset	onset	NOUN
admet-547	15	18	disease	disease	NOUN
admet-547	15	19	(	(	PUNCT
admet-547	15	20	about	about	ADP
admet-547	15	21	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-547	15	22	mailto:k.valko@ucl.ac.uk	mailto:k.valko@ucl.ac.uk	PROPN
admet-547	15	23	mailto:klara_valko@bio-mimetic-chromatography.com	mailto:klara_valko@bio-mimetic-chromatography.com	X
admet-547	15	24	admet	admet	PROPN
admet-547	15	25	&	&	CCONJ
admet-547	15	26	dmpk	dmpk	PROPN
admet-547	15	27	6(2	6(2	NUM
admet-547	15	28	)	)	PUNCT
admet-547	15	29	(	(	PUNCT
admet-547	15	30	2018	2018	NUM
admet-547	15	31	)	)	PUNCT
admet-547	15	32	176	176	NUM
admet-547	15	33	-	-	SYM
admet-547	15	34	189	189	NUM
admet-547	15	35	in	in	ADP
admet-547	15	36	vitro	vitro	X
admet-547	15	37	and	and	CCONJ
admet-547	15	38	in	in	ADP
admet-547	15	39	vivo	vivo	ADJ
admet-547	15	40	characterization	characterization	NOUN
admet-547	15	41	of	of	ADP
admet-547	15	42	gm6	gm6	PROPN
admet-547	15	43	doi	doi	NOUN
admet-547	15	44	:	:	PUNCT
admet-547	15	45	10.5599	10.5599	NUM
admet-547	15	46	/	/	SYM
admet-547	15	47	admet.547	admet.547	NOUN
admet-547	15	48	177	177	NUM
admet-547	15	49	70	70	NUM
admet-547	15	50	%	%	NOUN
admet-547	15	51	)	)	PUNCT
admet-547	15	52	or	or	CCONJ
admet-547	15	53	with	with	ADP
admet-547	15	54	initial	initial	ADJ
admet-547	15	55	trunk	trunk	NOUN
admet-547	15	56	or	or	CCONJ
admet-547	15	57	respiratory	respiratory	ADJ
admet-547	15	58	involvement	involvement	NOUN
admet-547	15	59	(	(	PUNCT
admet-547	15	60	5	5	NUM
admet-547	15	61	%	%	NOUN
admet-547	15	62	)	)	PUNCT
admet-547	15	63	.	.	PUNCT
admet-547	16	1	atypical	atypical	ADJ
admet-547	16	2	modes	mode	NOUN
admet-547	16	3	of	of	ADP
admet-547	16	4	presentation	presentation	NOUN
admet-547	16	5	can	can	AUX
admet-547	16	6	include	include	VERB
admet-547	16	7	weight	weight	NOUN
admet-547	16	8	loss	loss	NOUN
admet-547	16	9	,	,	PUNCT
admet-547	16	10	which	which	PRON
admet-547	16	11	is	be	AUX
admet-547	16	12	an	an	DET
admet-547	16	13	indicator	indicator	NOUN
admet-547	16	14	of	of	ADP
admet-547	16	15	a	a	DET
admet-547	16	16	poor	poor	ADJ
admet-547	16	17	prognosis	prognosis	NOUN
admet-547	16	18	,	,	PUNCT
admet-547	16	19	cramps	cramp	NOUN
admet-547	16	20	,	,	PUNCT
admet-547	16	21	emotional	emotional	ADJ
admet-547	16	22	lability	lability	NOUN
admet-547	16	23	and	and	CCONJ
admet-547	16	24	frontal	frontal	ADJ
admet-547	16	25	lobe	lobe	NOUN
admet-547	16	26	-	-	PUNCT
admet-547	16	27	type	type	NOUN
admet-547	16	28	cognitive	cognitive	ADJ
admet-547	16	29	dysfunction	dysfunction	NOUN
admet-547	16	30	.	.	PUNCT
admet-547	17	1	the	the	DET
admet-547	17	2	pathophysiological	pathophysiological	ADJ
admet-547	17	3	mechanisms	mechanism	NOUN
admet-547	17	4	underlying	underlie	VERB
admet-547	17	5	the	the	DET
admet-547	17	6	development	development	NOUN
admet-547	17	7	of	of	ADP
admet-547	17	8	als	al	NOUN
admet-547	17	9	seem	seem	VERB
admet-547	17	10	multifactorial	multifactorial	ADJ
admet-547	17	11	with	with	ADP
admet-547	17	12	emerging	emerge	VERB
admet-547	17	13	evidence	evidence	NOUN
admet-547	17	14	of	of	ADP
admet-547	17	15	a	a	DET
admet-547	17	16	complex	complex	ADJ
admet-547	17	17	interaction	interaction	NOUN
admet-547	17	18	between	between	ADP
admet-547	17	19	genetic	genetic	ADJ
admet-547	17	20	and	and	CCONJ
admet-547	17	21	molecular	molecular	ADJ
admet-547	17	22	pathways	pathway	NOUN
admet-547	17	23	[	[	X
admet-547	17	24	2,3	2,3	NUM
admet-547	17	25	]	]	PUNCT
admet-547	17	26	.	.	PUNCT
admet-547	18	1	als	als	NOUN
admet-547	18	2	is	be	AUX
admet-547	18	3	relentlessly	relentlessly	ADV
admet-547	18	4	progressive	progressive	ADJ
admet-547	18	5	–	–	PUNCT
admet-547	18	6	50	50	NUM
admet-547	18	7	%	%	NOUN
admet-547	18	8	of	of	ADP
admet-547	18	9	patients	patient	NOUN
admet-547	18	10	die	die	VERB
admet-547	18	11	within	within	ADP
admet-547	18	12	30	30	NUM
admet-547	18	13	months	month	NOUN
admet-547	18	14	of	of	ADP
admet-547	18	15	symptom	symptom	NOUN
admet-547	18	16	onset	onset	NOUN
admet-547	18	17	and	and	CCONJ
admet-547	18	18	about	about	ADV
admet-547	18	19	20	20	NUM
admet-547	18	20	%	%	NOUN
admet-547	18	21	of	of	ADP
admet-547	18	22	patients	patient	NOUN
admet-547	18	23	survive	survive	VERB
admet-547	18	24	between	between	ADP
admet-547	18	25	5	5	NUM
admet-547	18	26	10	10	NUM
admet-547	18	27	years	year	NOUN
admet-547	18	28	after	after	ADP
admet-547	18	29	symptom	symptom	NOUN
admet-547	18	30	onset	onset	NOUN
admet-547	18	31	.	.	PUNCT
admet-547	19	1	some	some	DET
admet-547	19	2	als	als	NOUN
admet-547	19	3	subtypes	subtype	NOUN
admet-547	19	4	tend	tend	VERB
admet-547	19	5	to	to	PART
admet-547	19	6	lead	lead	VERB
admet-547	19	7	to	to	ADP
admet-547	19	8	a	a	DET
admet-547	19	9	better	well	ADJ
admet-547	19	10	prognosis	prognosis	NOUN
admet-547	19	11	;	;	PUNCT
admet-547	19	12	for	for	ADP
admet-547	19	13	example	example	NOUN
admet-547	19	14	,	,	PUNCT
admet-547	19	15	flail	flail	NOUN
admet-547	19	16	-	-	PUNCT
admet-547	19	17	limb	limb	NOUN
admet-547	19	18	variants	variant	NOUN
admet-547	19	19	als	als	VERB
admet-547	19	20	and	and	CCONJ
admet-547	19	21	progressive	progressive	ADJ
admet-547	19	22	muscular	muscular	ADJ
admet-547	19	23	atrophy	atrophy	NOUN
admet-547	19	24	.	.	PUNCT
admet-547	20	1	both	both	PRON
admet-547	20	2	are	be	AUX
admet-547	20	3	predominantly	predominantly	ADV
admet-547	20	4	lower	low	ADJ
admet-547	20	5	motoneuron	motoneuron	NOUN
admet-547	20	6	forms	form	NOUN
admet-547	20	7	that	that	PRON
admet-547	20	8	are	be	AUX
admet-547	20	9	characterised	characterise	VERB
admet-547	20	10	by	by	ADP
admet-547	20	11	slower	slow	ADJ
admet-547	20	12	progression	progression	NOUN
admet-547	20	13	.	.	PUNCT
admet-547	21	1	advances	advance	NOUN
admet-547	21	2	in	in	ADP
admet-547	21	3	the	the	DET
admet-547	21	4	understanding	understanding	NOUN
admet-547	21	5	of	of	ADP
admet-547	21	6	the	the	DET
admet-547	21	7	glutamate	glutamate	ADJ
admet-547	21	8	neurotransmitter	neurotransmitter	NOUN
admet-547	21	9	system	system	NOUN
admet-547	21	10	and	and	CCONJ
admet-547	21	11	the	the	DET
admet-547	21	12	discovery	discovery	NOUN
admet-547	21	13	of	of	ADP
admet-547	21	14	causal	causal	ADJ
admet-547	21	15	genes	gene	NOUN
admet-547	21	16	linked	link	VERB
admet-547	21	17	to	to	ADP
admet-547	21	18	the	the	DET
admet-547	21	19	development	development	NOUN
admet-547	21	20	of	of	ADP
admet-547	21	21	familial	familial	ADJ
admet-547	21	22	als	als	NOUN
admet-547	21	23	has	have	AUX
admet-547	21	24	stimulated	stimulate	VERB
admet-547	21	25	research	research	NOUN
admet-547	21	26	interest	interest	NOUN
admet-547	21	27	.	.	PUNCT
admet-547	22	1	the	the	DET
admet-547	22	2	survival	survival	NOUN
admet-547	22	3	in	in	ADP
admet-547	22	4	als	als	NOUN
admet-547	22	5	is	be	AUX
admet-547	22	6	now	now	ADV
admet-547	22	7	understood	understand	VERB
admet-547	22	8	to	to	PART
admet-547	22	9	be	be	AUX
admet-547	22	10	dependent	dependent	ADJ
admet-547	22	11	on	on	ADP
admet-547	22	12	several	several	ADJ
admet-547	22	13	factors	factor	NOUN
admet-547	22	14	,	,	PUNCT
admet-547	22	15	such	such	ADJ
admet-547	22	16	as	as	ADP
admet-547	22	17	clinical	clinical	ADJ
admet-547	22	18	presentation	presentation	NOUN
admet-547	22	19	,	,	PUNCT
admet-547	22	20	the	the	DET
admet-547	22	21	rate	rate	NOUN
admet-547	22	22	of	of	ADP
admet-547	22	23	disease	disease	NOUN
admet-547	22	24	progression	progression	NOUN
admet-547	22	25	,	,	PUNCT
admet-547	22	26	early	early	ADJ
admet-547	22	27	presence	presence	NOUN
admet-547	22	28	of	of	ADP
admet-547	22	29	respiratory	respiratory	ADJ
admet-547	22	30	failure	failure	NOUN
admet-547	22	31	and	and	CCONJ
admet-547	22	32	the	the	DET
admet-547	22	33	nutritional	nutritional	ADJ
admet-547	22	34	status	status	NOUN
admet-547	22	35	of	of	ADP
admet-547	22	36	the	the	DET
admet-547	22	37	patients	patient	NOUN
admet-547	22	38	.	.	PUNCT
admet-547	23	1	the	the	DET
admet-547	23	2	process	process	NOUN
admet-547	23	3	by	by	ADP
admet-547	23	4	which	which	PRON
admet-547	23	5	motoneurons	motoneuron	NOUN
admet-547	23	6	die	die	VERB
admet-547	23	7	remains	remain	VERB
admet-547	23	8	unclear	unclear	ADJ
admet-547	23	9	with	with	SCONJ
admet-547	23	10	several	several	ADJ
admet-547	23	11	inter	inter	ADJ
admet-547	23	12	-	-	ADJ
admet-547	23	13	related	relate	VERB
admet-547	23	14	mechanisms	mechanism	NOUN
admet-547	23	15	suggested	suggest	VERB
admet-547	23	16	[	[	X
admet-547	23	17	1	1	NUM
admet-547	23	18	]	]	PUNCT
admet-547	23	19	.	.	PUNCT
admet-547	24	1	the	the	DET
admet-547	24	2	neurodegeneration	neurodegeneration	NOUN
admet-547	24	3	in	in	ADP
admet-547	24	4	als	als	NOUN
admet-547	24	5	may	may	AUX
admet-547	24	6	result	result	VERB
admet-547	24	7	from	from	ADP
admet-547	24	8	any	any	PRON
admet-547	24	9	of	of	ADP
admet-547	24	10	the	the	DET
admet-547	24	11	following	following	NOUN
admet-547	24	12	:	:	PUNCT
admet-547	24	13	complex	complex	ADJ
admet-547	24	14	interactions	interaction	NOUN
admet-547	24	15	of	of	ADP
admet-547	24	16	glutamate	glutamate	ADJ
admet-547	24	17	excitotoxicity	excitotoxicity	NOUN
admet-547	24	18	,	,	PUNCT
admet-547	24	19	generation	generation	NOUN
admet-547	24	20	of	of	ADP
admet-547	24	21	free	free	ADJ
admet-547	24	22	radicals	radical	NOUN
admet-547	24	23	,	,	PUNCT
admet-547	24	24	cytoplasmic	cytoplasmic	ADJ
admet-547	24	25	protein	protein	NOUN
admet-547	24	26	aggregates	aggregate	NOUN
admet-547	24	27	,	,	PUNCT
admet-547	24	28	sod1	sod1	ADJ
admet-547	24	29	enzymes	enzyme	NOUN
admet-547	24	30	,	,	PUNCT
admet-547	24	31	combined	combine	VERB
admet-547	24	32	with	with	ADP
admet-547	24	33	mitochondrial	mitochondrial	ADJ
admet-547	24	34	dysfunction	dysfunction	NOUN
admet-547	24	35	,	,	PUNCT
admet-547	24	36	and	and	CCONJ
admet-547	24	37	disruption	disruption	NOUN
admet-547	24	38	of	of	ADP
admet-547	24	39	axonal	axonal	ADJ
admet-547	24	40	transport	transport	NOUN
admet-547	24	41	processes	process	NOUN
admet-547	24	42	through	through	ADP
admet-547	24	43	the	the	DET
admet-547	24	44	accumulation	accumulation	NOUN
admet-547	24	45	of	of	ADP
admet-547	24	46	neurofilament	neurofilament	ADJ
admet-547	24	47	intracellular	intracellular	ADJ
admet-547	24	48	aggregates	aggregate	NOUN
admet-547	24	49	.	.	PUNCT
admet-547	25	1	riluzole	riluzole	PROPN
admet-547	25	2	has	have	AUX
admet-547	25	3	been	be	AUX
admet-547	25	4	approved	approve	VERB
admet-547	25	5	by	by	ADP
admet-547	25	6	the	the	DET
admet-547	25	7	fda	fda	PROPN
admet-547	25	8	for	for	ADP
admet-547	25	9	20	20	NUM
admet-547	25	10	years	year	NOUN
admet-547	25	11	and	and	CCONJ
admet-547	25	12	inhibits	inhibit	VERB
admet-547	25	13	the	the	DET
admet-547	25	14	release	release	NOUN
admet-547	25	15	of	of	ADP
admet-547	25	16	glutamic	glutamic	ADJ
admet-547	25	17	acid	acid	NOUN
admet-547	25	18	from	from	ADP
admet-547	25	19	cultured	cultured	ADJ
admet-547	25	20	neurons	neuron	NOUN
admet-547	25	21	,	,	PUNCT
admet-547	25	22	from	from	ADP
admet-547	25	23	brain	brain	NOUN
admet-547	25	24	slices	slice	NOUN
admet-547	25	25	,	,	PUNCT
admet-547	25	26	and	and	CCONJ
admet-547	25	27	from	from	ADP
admet-547	25	28	corticostriatal	corticostriatal	ADJ
admet-547	25	29	neurons	neuron	NOUN
admet-547	25	30	in	in	ADP
admet-547	25	31	vivo	vivo	NOUN
admet-547	25	32	.	.	PUNCT
admet-547	26	1	it	it	PRON
admet-547	26	2	increases	increase	VERB
admet-547	26	3	the	the	DET
admet-547	26	4	als	als	NOUN
admet-547	26	5	patients	patient	NOUN
admet-547	26	6	’	'	PUNCT
admet-547	26	7	life	life	NOUN
admet-547	26	8	by	by	ADP
admet-547	26	9	two	two	NUM
admet-547	26	10	to	to	PART
admet-547	26	11	three	three	NUM
admet-547	26	12	months	month	NOUN
admet-547	26	13	by	by	ADP
admet-547	26	14	blocking	block	VERB
admet-547	26	15	glutamatergic	glutamatergic	ADJ
admet-547	26	16	neurotransmission	neurotransmission	NOUN
admet-547	26	17	in	in	ADP
admet-547	26	18	the	the	DET
admet-547	26	19	cns	cns	NOUN
admet-547	26	20	.	.	PUNCT
admet-547	27	1	there	there	PRON
admet-547	27	2	is	be	VERB
admet-547	27	3	an	an	DET
admet-547	27	4	unmet	unmet	NOUN
admet-547	27	5	medical	medical	ADJ
admet-547	27	6	need	need	NOUN
admet-547	27	7	to	to	PART
admet-547	27	8	lengthen	lengthen	VERB
admet-547	27	9	the	the	DET
admet-547	27	10	life	life	NOUN
admet-547	27	11	expectancy	expectancy	NOUN
admet-547	27	12	,	,	PUNCT
admet-547	27	13	slow	slow	VERB
admet-547	27	14	down	down	ADP
admet-547	27	15	the	the	DET
admet-547	27	16	disease	disease	NOUN
admet-547	27	17	progression	progression	NOUN
admet-547	27	18	and	and	CCONJ
admet-547	27	19	ultimately	ultimately	ADV
admet-547	27	20	cure	cure	VERB
admet-547	27	21	als	als	NOUN
admet-547	27	22	patients	patient	NOUN
admet-547	27	23	.	.	PUNCT
admet-547	28	1	discovering	discover	VERB
admet-547	28	2	a	a	DET
admet-547	28	3	therapeutic	therapeutic	ADJ
admet-547	28	4	agent	agent	NOUN
admet-547	28	5	that	that	PRON
admet-547	28	6	significantly	significantly	ADV
admet-547	28	7	increases	increase	VERB
admet-547	28	8	the	the	DET
admet-547	28	9	life	life	NOUN
admet-547	28	10	expectancy	expectancy	NOUN
admet-547	28	11	of	of	ADP
admet-547	28	12	als	als	NOUN
admet-547	28	13	patients	patient	NOUN
admet-547	28	14	or	or	CCONJ
admet-547	28	15	cures	cure	VERB
admet-547	28	16	the	the	DET
admet-547	28	17	disease	disease	NOUN
admet-547	28	18	would	would	AUX
admet-547	28	19	provide	provide	VERB
admet-547	28	20	a	a	DET
admet-547	28	21	significant	significant	ADJ
admet-547	28	22	breakthrough	breakthrough	NOUN
admet-547	28	23	in	in	ADP
admet-547	28	24	this	this	DET
admet-547	28	25	field	field	NOUN
admet-547	28	26	.	.	PUNCT
admet-547	29	1	potential	potential	ADJ
admet-547	29	2	disease	disease	NOUN
admet-547	29	3	mechanisms	mechanism	VERB
admet-547	29	4	protein	protein	NOUN
admet-547	29	5	misfolding	misfolde	VERB
admet-547	29	6	and	and	CCONJ
admet-547	29	7	protein	protein	NOUN
admet-547	29	8	aggregation	aggregation	NOUN
admet-547	29	9	are	be	AUX
admet-547	29	10	known	know	VERB
admet-547	29	11	characteristics	characteristic	NOUN
admet-547	29	12	of	of	ADP
admet-547	29	13	various	various	ADJ
admet-547	29	14	diseases	disease	NOUN
admet-547	29	15	,	,	PUNCT
admet-547	29	16	including	include	VERB
admet-547	29	17	major	major	ADJ
admet-547	29	18	neurodegenerative	neurodegenerative	ADJ
admet-547	29	19	disorders	disorder	NOUN
admet-547	29	20	such	such	ADJ
admet-547	29	21	as	as	ADP
admet-547	29	22	als	al	NOUN
admet-547	29	23	,	,	PUNCT
admet-547	29	24	alzheimer	alzheimer	PROPN
admet-547	29	25	’s	’s	PART
admet-547	29	26	and	and	CCONJ
admet-547	29	27	parkinson	parkinson	NOUN
admet-547	29	28	’s	’s	PART
admet-547	29	29	diseases	disease	NOUN
admet-547	29	30	.	.	PUNCT
admet-547	30	1	while	while	SCONJ
admet-547	30	2	the	the	DET
admet-547	30	3	mechanistic	mechanistic	ADJ
admet-547	30	4	link	link	NOUN
admet-547	30	5	between	between	ADP
admet-547	30	6	protein	protein	NOUN
admet-547	30	7	aggregation	aggregation	NOUN
admet-547	30	8	and	and	CCONJ
admet-547	30	9	cell	cell	NOUN
admet-547	30	10	degeneration	degeneration	NOUN
admet-547	30	11	remains	remain	VERB
admet-547	30	12	unclear	unclear	ADJ
admet-547	30	13	,	,	PUNCT
admet-547	30	14	approaches	approach	VERB
admet-547	30	15	to	to	PART
admet-547	30	16	halt	halt	VERB
admet-547	30	17	or	or	CCONJ
admet-547	30	18	reverse	reverse	VERB
admet-547	30	19	the	the	DET
admet-547	30	20	aggregation	aggregation	NOUN
admet-547	30	21	process	process	NOUN
admet-547	30	22	are	be	AUX
admet-547	30	23	a	a	DET
admet-547	30	24	focus	focus	NOUN
admet-547	30	25	of	of	ADP
admet-547	30	26	current	current	ADJ
admet-547	30	27	drug	drug	NOUN
admet-547	30	28	discovery	discovery	NOUN
admet-547	30	29	approaches	approach	NOUN
admet-547	30	30	.	.	PUNCT
admet-547	31	1	insulin	insulin	NOUN
admet-547	31	2	-	-	PUNCT
admet-547	31	3	like	like	ADJ
admet-547	31	4	growth	growth	NOUN
admet-547	31	5	factor	factor	NOUN
admet-547	31	6	-	-	PUNCT
admet-547	31	7	i	i	PRON
admet-547	31	8	(	(	PUNCT
admet-547	31	9	igf	igf	PROPN
admet-547	31	10	-	-	PROPN
admet-547	31	11	i	i	NOUN
admet-547	31	12	)	)	PUNCT
admet-547	31	13	receptors	receptor	NOUN
admet-547	31	14	are	be	AUX
admet-547	31	15	present	present	ADJ
admet-547	31	16	in	in	ADP
admet-547	31	17	the	the	DET
admet-547	31	18	spinal	spinal	ADJ
admet-547	31	19	cord	cord	NOUN
admet-547	31	20	and	and	CCONJ
admet-547	31	21	,	,	PUNCT
admet-547	31	22	as	as	ADP
admet-547	31	23	members	member	NOUN
admet-547	31	24	of	of	ADP
admet-547	31	25	the	the	DET
admet-547	31	26	neurotrophin	neurotrophin	PROPN
admet-547	31	27	receptor	receptor	NOUN
admet-547	31	28	family	family	NOUN
admet-547	31	29	,	,	PUNCT
admet-547	31	30	igf	igf	PROPN
admet-547	31	31	-	-	PROPN
admet-547	31	32	i	i	PROPN
admet-547	31	33	receptors	receptor	NOUN
admet-547	31	34	mediate	mediate	VERB
admet-547	31	35	signal	signal	ADJ
admet-547	31	36	transduction	transduction	NOUN
admet-547	31	37	via	via	ADP
admet-547	31	38	the	the	DET
admet-547	31	39	tyrosine	tyrosine	NOUN
admet-547	31	40	kinase	kinase	PROPN
admet-547	31	41	domain	domain	PROPN
admet-547	31	42	.	.	PUNCT
admet-547	32	1	igf	igf	PROPN
admet-547	32	2	-	-	PROPN
admet-547	32	3	i	i	PRON
admet-547	32	4	was	be	AUX
admet-547	32	5	found	find	VERB
admet-547	32	6	to	to	PART
admet-547	32	7	prevent	prevent	VERB
admet-547	32	8	the	the	DET
admet-547	32	9	loss	loss	NOUN
admet-547	32	10	of	of	ADP
admet-547	32	11	choline	choline	NOUN
admet-547	32	12	acetyltransferase	acetyltransferase	NOUN
admet-547	32	13	activity	activity	NOUN
admet-547	32	14	in	in	ADP
admet-547	32	15	embryonic	embryonic	ADJ
admet-547	32	16	spinal	spinal	ADJ
admet-547	32	17	cord	cord	NOUN
admet-547	32	18	cultures	culture	NOUN
admet-547	32	19	,	,	PUNCT
admet-547	32	20	as	as	ADV
admet-547	32	21	well	well	ADV
admet-547	32	22	as	as	ADP
admet-547	32	23	reducing	reduce	VERB
admet-547	32	24	the	the	DET
admet-547	32	25	programmed	program	VERB
admet-547	32	26	cell	cell	NOUN
admet-547	32	27	death	death	NOUN
admet-547	32	28	of	of	ADP
admet-547	32	29	motor	motor	NOUN
admet-547	32	30	neurons	neuron	NOUN
admet-547	32	31	in	in	ADP
admet-547	32	32	vivo	vivo	NOUN
admet-547	32	33	during	during	ADP
admet-547	32	34	normal	normal	ADJ
admet-547	32	35	development	development	NOUN
admet-547	32	36	or	or	CCONJ
admet-547	32	37	following	follow	VERB
admet-547	32	38	axotomy	axotomy	ADV
admet-547	32	39	[	[	X
admet-547	32	40	4	4	NUM
admet-547	32	41	]	]	PUNCT
admet-547	32	42	.	.	PUNCT
admet-547	33	1	over	over	ADP
admet-547	33	2	the	the	DET
admet-547	33	3	past	past	ADJ
admet-547	33	4	30	30	NUM
admet-547	33	5	years	year	NOUN
admet-547	33	6	,	,	PUNCT
admet-547	33	7	glucose	glucose	NOUN
admet-547	33	8	intolerance	intolerance	NOUN
admet-547	33	9	has	have	AUX
admet-547	33	10	been	be	AUX
admet-547	33	11	reported	report	VERB
admet-547	33	12	in	in	ADP
admet-547	33	13	a	a	DET
admet-547	33	14	significant	significant	ADJ
admet-547	33	15	percentage	percentage	NOUN
admet-547	33	16	of	of	ADP
admet-547	33	17	als	als	NOUN
admet-547	33	18	patients	patient	NOUN
admet-547	33	19	.	.	PUNCT
admet-547	34	1	a	a	DET
admet-547	34	2	reduction	reduction	NOUN
admet-547	34	3	in	in	ADP
admet-547	34	4	glucose	glucose	NOUN
admet-547	34	5	receptor	receptor	NOUN
admet-547	34	6	space	space	NOUN
admet-547	34	7	and	and	CCONJ
admet-547	34	8	insulin	insulin	NOUN
admet-547	34	9	resistance	resistance	NOUN
admet-547	34	10	has	have	AUX
admet-547	34	11	been	be	AUX
admet-547	34	12	postulated	postulate	VERB
admet-547	34	13	for	for	ADP
admet-547	34	14	a	a	DET
admet-547	34	15	number	number	NOUN
admet-547	34	16	of	of	ADP
admet-547	34	17	neuromuscular	neuromuscular	ADJ
admet-547	34	18	diseases	disease	NOUN
admet-547	34	19	[	[	X
admet-547	34	20	5	5	NUM
admet-547	34	21	]	]	PUNCT
admet-547	34	22	.	.	PUNCT
admet-547	35	1	the	the	DET
admet-547	35	2	structurally	structurally	ADV
admet-547	35	3	related	relate	VERB
admet-547	35	4	peptides	peptide	NOUN
admet-547	35	5	,	,	PUNCT
admet-547	35	6	insulin	insulin	NOUN
admet-547	35	7	and	and	CCONJ
admet-547	35	8	insulin	insulin	NOUN
admet-547	35	9	-	-	PUNCT
admet-547	35	10	like	like	ADJ
admet-547	35	11	growth	growth	NOUN
admet-547	35	12	factors	factor	NOUN
admet-547	35	13	(	(	PUNCT
admet-547	35	14	igf	igf	X
admet-547	35	15	-	-	PROPN
admet-547	35	16	i	i	PROPN
admet-547	35	17	and	and	CCONJ
admet-547	35	18	igf	igf	PROPN
admet-547	35	19	-	-	PROPN
admet-547	35	20	ii	ii	NOUN
admet-547	35	21	)	)	PUNCT
admet-547	35	22	,	,	PUNCT
admet-547	35	23	have	have	VERB
admet-547	35	24	neurotrophic	neurotrophic	ADJ
admet-547	35	25	properties	property	NOUN
admet-547	35	26	and	and	CCONJ
admet-547	35	27	potentially	potentially	ADV
admet-547	35	28	could	could	AUX
admet-547	35	29	be	be	AUX
admet-547	35	30	of	of	ADP
admet-547	35	31	therapeutic	therapeutic	ADJ
admet-547	35	32	value	value	NOUN
admet-547	35	33	in	in	ADP
admet-547	35	34	human	human	ADJ
admet-547	35	35	neurodegenerative	neurodegenerative	ADJ
admet-547	35	36	disorders	disorder	NOUN
admet-547	35	37	[	[	X
admet-547	35	38	6	6	NUM
admet-547	35	39	]	]	PUNCT
admet-547	35	40	.	.	PUNCT
admet-547	36	1	the	the	DET
admet-547	36	2	nerve	nerve	NOUN
admet-547	36	3	growth	growth	NOUN
admet-547	36	4	factor	factor	NOUN
admet-547	36	5	(	(	PUNCT
admet-547	36	6	ngf	ngf	ADV
admet-547	36	7	)	)	PUNCT
admet-547	36	8	was	be	AUX
admet-547	36	9	discovered	discover	VERB
admet-547	36	10	by	by	ADP
admet-547	36	11	levi	levi	PROPN
admet-547	36	12	-	-	PUNCT
admet-547	36	13	montalcini	montalcini	PROPN
admet-547	36	14	and	and	CCONJ
admet-547	36	15	cohen	cohen	VERB
admet-547	36	16	some	some	DET
admet-547	36	17	50	50	NUM
admet-547	36	18	years	year	NOUN
admet-547	36	19	ago	ago	ADV
admet-547	37	1	[	[	X
admet-547	37	2	7	7	X
admet-547	37	3	]	]	PUNCT
admet-547	37	4	which	which	PRON
admet-547	37	5	supported	support	VERB
admet-547	37	6	the	the	DET
admet-547	37	7	concept	concept	NOUN
admet-547	37	8	that	that	SCONJ
admet-547	37	9	secreted	secrete	VERB
admet-547	37	10	molecules	molecule	NOUN
admet-547	37	11	produced	produce	VERB
admet-547	37	12	by	by	ADP
admet-547	37	13	the	the	DET
admet-547	37	14	target	target	NOUN
admet-547	37	15	of	of	ADP
admet-547	37	16	a	a	DET
admet-547	37	17	developing	develop	VERB
admet-547	37	18	neuron	neuron	NOUN
admet-547	37	19	are	be	AUX
admet-547	37	20	required	require	VERB
admet-547	37	21	for	for	SCONJ
admet-547	37	22	it	it	PRON
admet-547	37	23	to	to	PART
admet-547	37	24	survive	survive	VERB
admet-547	37	25	programmed	programmed	ADJ
admet-547	37	26	cell	cell	NOUN
admet-547	37	27	death	death	NOUN
admet-547	37	28	(	(	PUNCT
admet-547	37	29	pcd	pcd	PROPN
admet-547	37	30	)	)	PUNCT
admet-547	37	31	.	.	PUNCT
admet-547	38	1	this	this	DET
admet-547	38	2	neurotrophic	neurotrophic	ADJ
admet-547	38	3	hypothesis	hypothesis	NOUN
admet-547	38	4	provided	provide	VERB
admet-547	38	5	the	the	DET
admet-547	38	6	klara	klara	PROPN
admet-547	38	7	valko	valko	PROPN
admet-547	38	8	et	et	PROPN
admet-547	38	9	al	al	PROPN
admet-547	38	10	.	.	PROPN
admet-547	38	11	admet	admet	PROPN
admet-547	38	12	&	&	CCONJ
admet-547	38	13	dmpk	dmpk	PROPN
admet-547	38	14	6(2	6(2	NUM
admet-547	38	15	)	)	PUNCT
admet-547	38	16	(	(	PUNCT
admet-547	38	17	2018	2018	NUM
admet-547	38	18	)	)	PUNCT
admet-547	38	19	176	176	NUM
admet-547	38	20	-	-	SYM
admet-547	38	21	189	189	NUM
admet-547	38	22	178	178	NUM
admet-547	38	23	background	background	NOUN
admet-547	38	24	for	for	ADP
admet-547	38	25	the	the	DET
admet-547	38	26	identification	identification	NOUN
admet-547	38	27	of	of	ADP
admet-547	38	28	neurotrophic	neurotrophic	ADJ
admet-547	38	29	factors	factor	NOUN
admet-547	38	30	(	(	PUNCT
admet-547	38	31	ntfs	ntfs	PROPN
admet-547	38	32	)	)	PUNCT
admet-547	38	33	.	.	PUNCT
admet-547	39	1	the	the	DET
admet-547	39	2	motor	motor	PROPN
admet-547	39	3	neuron	neuron	PROPN
admet-547	39	4	trophic	trophic	PROPN
admet-547	39	5	factor	factor	NOUN
admet-547	39	6	(	(	PUNCT
admet-547	39	7	mntf	mntf	VERB
admet-547	39	8	)	)	PUNCT
admet-547	39	9	is	be	AUX
admet-547	39	10	a	a	DET
admet-547	39	11	33	33	NUM
admet-547	39	12	-	-	PUNCT
admet-547	39	13	amino	amino	NOUN
admet-547	39	14	acid	acid	NOUN
admet-547	39	15	peptide	peptide	NOUN
admet-547	39	16	.	.	PUNCT
admet-547	40	1	it	it	PRON
admet-547	40	2	was	be	AUX
admet-547	40	3	identified	identify	VERB
admet-547	40	4	,	,	PUNCT
admet-547	40	5	isolated	isolated	ADJ
admet-547	40	6	and	and	CCONJ
admet-547	40	7	characterized	characterize	VERB
admet-547	40	8	by	by	ADP
admet-547	40	9	using	use	VERB
admet-547	40	10	monoclonal	monoclonal	NOUN
admet-547	40	11	antibodies	antibody	NOUN
admet-547	40	12	against	against	ADP
admet-547	40	13	a	a	DET
admet-547	40	14	35	35	NUM
admet-547	40	15	kd	kd	NOUN
admet-547	40	16	rat	rat	NOUN
admet-547	40	17	peptide	peptide	NOUN
admet-547	40	18	,	,	PUNCT
admet-547	40	19	isolated	isolate	VERB
admet-547	40	20	from	from	ADP
admet-547	40	21	3	3	NUM
admet-547	40	22	-	-	PUNCT
admet-547	40	23	week	week	NOUN
admet-547	40	24	-	-	PUNCT
admet-547	40	25	old	old	ADJ
admet-547	40	26	rat	rat	NOUN
admet-547	40	27	muscle	muscle	NOUN
admet-547	40	28	extract	extract	NOUN
admet-547	40	29	.	.	PUNCT
admet-547	41	1	mntf	mntf	PROPN
admet-547	41	2	was	be	AUX
admet-547	41	3	subsequently	subsequently	ADV
admet-547	41	4	derived	derive	VERB
admet-547	41	5	by	by	ADP
admet-547	41	6	the	the	DET
admet-547	41	7	cloning	cloning	NOUN
admet-547	41	8	of	of	ADP
admet-547	41	9	a	a	DET
admet-547	41	10	recombinant	recombinant	ADJ
admet-547	41	11	mntf1	mntf1	NOUN
admet-547	41	12	-	-	PUNCT
admet-547	41	13	f6	f6	NUM
admet-547	41	14	gene	gene	NOUN
admet-547	41	15	from	from	ADP
admet-547	41	16	a	a	DET
admet-547	41	17	human	human	ADJ
admet-547	41	18	retinoblastoma	retinoblastoma	NOUN
admet-547	41	19	cdna	cdna	PROPN
admet-547	41	20	expression	expression	NOUN
admet-547	41	21	library	library	NOUN
admet-547	41	22	(	(	PUNCT
admet-547	41	23	clontech	clontech	NOUN
admet-547	41	24	)	)	PUNCT
admet-547	41	25	and	and	CCONJ
admet-547	41	26	analyzed	analyze	VERB
admet-547	41	27	to	to	PART
admet-547	41	28	determine	determine	VERB
admet-547	41	29	its	its	PRON
admet-547	41	30	amino	amino	NOUN
admet-547	41	31	acid	acid	NOUN
admet-547	41	32	and	and	CCONJ
admet-547	41	33	cdna	cdna	PROPN
admet-547	41	34	sequences	sequence	NOUN
admet-547	42	1	[	[	X
admet-547	42	2	8	8	NUM
admet-547	42	3	]	]	PUNCT
admet-547	42	4	.	.	PUNCT
admet-547	43	1	gm6	gm6	PROPN
admet-547	43	2	is	be	AUX
admet-547	43	3	a	a	DET
admet-547	43	4	6	6	NUM
admet-547	43	5	amino	amino	NOUN
admet-547	43	6	acid	acid	NOUN
admet-547	43	7	analogue	analogue	NOUN
admet-547	43	8	of	of	ADP
admet-547	43	9	the	the	DET
admet-547	43	10	mntf	mntf	ADJ
admet-547	43	11	active	active	ADJ
admet-547	43	12	site	site	NOUN
admet-547	43	13	.	.	PUNCT
admet-547	44	1	gm6	gm6	PROPN
admet-547	44	2	is	be	AUX
admet-547	44	3	a	a	DET
admet-547	44	4	cationic	cationic	ADJ
admet-547	44	5	linear	linear	NOUN
admet-547	44	6	peptide	peptide	NOUN
admet-547	44	7	drug	drug	NOUN
admet-547	44	8	consisting	consist	VERB
admet-547	44	9	of	of	ADP
admet-547	44	10	6	6	NUM
admet-547	44	11	amino	amino	NOUN
admet-547	44	12	acids	acid	NOUN
admet-547	44	13	in	in	ADP
admet-547	44	14	their	their	PRON
admet-547	44	15	natural	natural	ADJ
admet-547	44	16	configurations	configuration	NOUN
admet-547	44	17	(	(	PUNCT
admet-547	44	18	phe	phe	PROPN
admet-547	44	19	-	-	PUNCT
admet-547	44	20	ser	ser	NOUN
admet-547	44	21	-	-	PUNCT
admet-547	44	22	arg	arg	NOUN
admet-547	44	23	-	-	PUNCT
admet-547	44	24	tyr	tyr	PROPN
admet-547	44	25	-	-	PUNCT
admet-547	44	26	ala	ala	ADJ
admet-547	44	27	-	-	PUNCT
admet-547	44	28	arg	arg	NOUN
admet-547	44	29	acetate	acetate	NOUN
admet-547	44	30	salt	salt	NOUN
admet-547	44	31	)	)	PUNCT
admet-547	45	1	[	[	X
admet-547	45	2	9,10	9,10	NUM
admet-547	45	3	]	]	X
admet-547	45	4	.	.	PUNCT
admet-547	46	1	mntf	mntf	PROPN
admet-547	46	2	33	33	NUM
admet-547	46	3	(	(	PUNCT
admet-547	46	4	1	1	NUM
admet-547	46	5	µg	µg	NOUN
admet-547	46	6	/	/	SYM
admet-547	46	7	ml	ml	NOUN
admet-547	46	8	)	)	PUNCT
admet-547	46	9	and	and	CCONJ
admet-547	46	10	mntf	mntf	VERB
admet-547	46	11	10	10	NUM
admet-547	46	12	(	(	PUNCT
admet-547	46	13	1	1	NUM
admet-547	46	14	µg	µg	ADJ
admet-547	46	15	/	/	SYM
admet-547	46	16	ml	ml	NOUN
admet-547	46	17	)	)	PUNCT
admet-547	46	18	induced	induced	ADJ
admet-547	46	19	differentiation	differentiation	NOUN
admet-547	46	20	of	of	ADP
admet-547	46	21	embryonic	embryonic	ADJ
admet-547	46	22	stem	stem	NOUN
admet-547	46	23	cells	cell	NOUN
admet-547	46	24	(	(	PUNCT
admet-547	46	25	es	es	NOUN
admet-547	46	26	)	)	PUNCT
admet-547	46	27	that	that	PRON
admet-547	46	28	resulted	result	VERB
admet-547	46	29	in	in	ADP
admet-547	46	30	the	the	DET
admet-547	46	31	expression	expression	NOUN
admet-547	46	32	of	of	ADP
admet-547	46	33	the	the	DET
admet-547	46	34	mature	mature	ADJ
admet-547	46	35	motor	motor	NOUN
admet-547	46	36	neuron	neuron	NOUN
admet-547	46	37	transcription	transcription	NOUN
admet-547	46	38	factors	factor	VERB
admet-547	46	39	hb9	hb9	PROPN
admet-547	46	40	,	,	PUNCT
admet-547	46	41	chat	chat	VERB
admet-547	46	42	and	and	CCONJ
admet-547	46	43	islet	islet	NOUN
admet-547	46	44	1/2	1/2	NUM
admet-547	46	45	.	.	PUNCT
admet-547	47	1	mntf	mntf	PROPN
admet-547	47	2	was	be	AUX
admet-547	47	3	found	find	VERB
admet-547	47	4	to	to	PART
admet-547	47	5	have	have	VERB
admet-547	47	6	an	an	DET
admet-547	47	7	affinity	affinity	NOUN
admet-547	47	8	for	for	ADP
admet-547	47	9	the	the	DET
admet-547	47	10	insulin	insulin	NOUN
admet-547	47	11	receptor	receptor	NOUN
admet-547	47	12	(	(	PUNCT
admet-547	47	13	ir	ir	NOUN
admet-547	47	14	)	)	PUNCT
admet-547	47	15	and	and	CCONJ
admet-547	47	16	the	the	DET
admet-547	47	17	insulin	insulin	NOUN
admet-547	47	18	-	-	PUNCT
admet-547	47	19	like	like	ADJ
admet-547	47	20	growth	growth	NOUN
admet-547	47	21	factor	factor	NOUN
admet-547	47	22	(	(	PUNCT
admet-547	47	23	igf	igf	PROPN
admet-547	47	24	)	)	PUNCT
admet-547	47	25	of	of	ADP
admet-547	47	26	es	es	X
admet-547	47	27	cells	cell	NOUN
admet-547	47	28	that	that	PRON
admet-547	47	29	resulted	result	VERB
admet-547	47	30	in	in	ADP
admet-547	47	31	the	the	DET
admet-547	47	32	autophosphorylation	autophosphorylation	NOUN
admet-547	47	33	of	of	ADP
admet-547	47	34	tyr972	tyr972	PROPN
admet-547	47	35	and	and	CCONJ
admet-547	47	36	tyr	tyr	PROPN
admet-547	47	37	1162/1163	1162/1163	NUM
admet-547	47	38	markers	marker	NOUN
admet-547	47	39	of	of	ADP
admet-547	47	40	ir	ir	NOUN
admet-547	47	41	activation	activation	NOUN
admet-547	47	42	receptor	receptor	NOUN
admet-547	47	43	(	(	PUNCT
admet-547	47	44	igf-1r	igf-1r	PROPN
admet-547	47	45	)	)	PUNCT
admet-547	47	46	based	base	VERB
admet-547	47	47	on	on	ADP
admet-547	47	48	embryonic	embryonic	ADJ
admet-547	47	49	stem	stem	NOUN
admet-547	47	50	cell	cell	NOUN
admet-547	47	51	differentiation	differentiation	NOUN
admet-547	47	52	studies	study	NOUN
admet-547	47	53	[	[	X
admet-547	47	54	10	10	NUM
admet-547	47	55	]	]	PUNCT
admet-547	47	56	.	.	PUNCT
admet-547	48	1	in	in	ADP
admet-547	48	2	this	this	DET
admet-547	48	3	paper	paper	NOUN
admet-547	48	4	,	,	PUNCT
admet-547	48	5	the	the	DET
admet-547	48	6	in	in	ADP
admet-547	48	7	vitro	vitro	X
admet-547	48	8	and	and	CCONJ
admet-547	48	9	in	in	ADP
admet-547	48	10	vivo	vivo	ADJ
admet-547	48	11	properties	property	NOUN
admet-547	48	12	of	of	ADP
admet-547	48	13	the	the	DET
admet-547	48	14	mntf-33	mntf-33	PROPN
admet-547	48	15	derived	derive	VERB
admet-547	48	16	gm6	gm6	PROPN
admet-547	48	17	,	,	PUNCT
admet-547	48	18	a	a	DET
admet-547	48	19	six	six	NUM
admet-547	48	20	-	-	PUNCT
admet-547	48	21	amino	amino	NOUN
admet-547	48	22	acid	acid	NOUN
admet-547	48	23	part	part	NOUN
admet-547	48	24	of	of	ADP
admet-547	48	25	the	the	DET
admet-547	48	26	endogenous	endogenous	ADJ
admet-547	48	27	motor	motor	NOUN
admet-547	48	28	neuron	neuron	PROPN
admet-547	48	29	trophic	trophic	PROPN
admet-547	48	30	factor	factor	NOUN
admet-547	48	31	is	be	AUX
admet-547	48	32	described	describe	VERB
admet-547	48	33	,	,	PUNCT
admet-547	48	34	summarizing	summarize	VERB
admet-547	48	35	its	its	PRON
admet-547	48	36	potential	potential	NOUN
admet-547	48	37	as	as	ADP
admet-547	48	38	a	a	DET
admet-547	48	39	new	new	ADJ
admet-547	48	40	peptide	peptide	NOUN
admet-547	48	41	therapeutic	therapeutic	ADJ
admet-547	48	42	for	for	ADP
admet-547	48	43	als	al	NOUN
admet-547	48	44	.	.	PUNCT
admet-547	49	1	peptide	peptide	NOUN
admet-547	49	2	therapeutics	therapeutic	NOUN
admet-547	49	3	have	have	VERB
admet-547	49	4	several	several	ADJ
admet-547	49	5	advantages	advantage	NOUN
admet-547	49	6	being	be	AUX
admet-547	49	7	highly	highly	ADV
admet-547	49	8	selective	selective	ADJ
admet-547	49	9	and	and	CCONJ
admet-547	49	10	efficacious	efficacious	ADJ
admet-547	49	11	and	and	CCONJ
admet-547	49	12	are	be	AUX
admet-547	49	13	well	well	ADV
admet-547	49	14	tolerated	tolerate	VERB
admet-547	49	15	with	with	ADP
admet-547	49	16	good	good	ADJ
admet-547	49	17	safety	safety	NOUN
admet-547	49	18	profiles	profile	NOUN
admet-547	49	19	[	[	X
admet-547	49	20	11	11	NUM
admet-547	49	21	]	]	PUNCT
admet-547	49	22	.	.	PUNCT
admet-547	50	1	the	the	DET
admet-547	50	2	challenges	challenge	NOUN
admet-547	50	3	with	with	ADP
admet-547	50	4	peptide	peptide	ADJ
admet-547	50	5	therapeutics	therapeutic	NOUN
admet-547	50	6	are	be	AUX
admet-547	50	7	their	their	PRON
admet-547	50	8	impaired	impaired	ADJ
admet-547	50	9	cell	cell	NOUN
admet-547	50	10	permeability	permeability	NOUN
admet-547	50	11	and	and	CCONJ
admet-547	50	12	their	their	PRON
admet-547	50	13	stability	stability	NOUN
admet-547	50	14	in	in	ADP
admet-547	50	15	plasma	plasma	NOUN
admet-547	50	16	that	that	PRON
admet-547	50	17	has	have	VERB
admet-547	50	18	to	to	PART
admet-547	50	19	be	be	AUX
admet-547	50	20	improved	improve	VERB
admet-547	50	21	[	[	X
admet-547	50	22	11	11	NUM
admet-547	50	23	]	]	PUNCT
admet-547	50	24	.	.	PUNCT
admet-547	51	1	therefore	therefore	ADV
admet-547	51	2	,	,	PUNCT
admet-547	51	3	the	the	DET
admet-547	51	4	biomimetic	biomimetic	ADJ
admet-547	51	5	properties	property	NOUN
admet-547	51	6	of	of	ADP
admet-547	51	7	gm6	gm6	PROPN
admet-547	51	8	have	have	AUX
admet-547	51	9	been	be	AUX
admet-547	51	10	measured	measure	VERB
admet-547	51	11	by	by	ADP
admet-547	51	12	hplc	hplc	NOUN
admet-547	51	13	using	use	VERB
admet-547	51	14	chemically	chemically	ADV
admet-547	51	15	bonded	bond	VERB
admet-547	51	16	protein	protein	NOUN
admet-547	51	17	and	and	CCONJ
admet-547	51	18	phospholipid	phospholipid	NOUN
admet-547	51	19	stationary	stationary	ADJ
admet-547	51	20	phases	phase	NOUN
admet-547	51	21	[	[	X
admet-547	51	22	12	12	NUM
admet-547	51	23	]	]	PUNCT
admet-547	51	24	.	.	PUNCT
admet-547	52	1	the	the	DET
admet-547	52	2	models	model	NOUN
admet-547	52	3	developed	develop	VERB
admet-547	52	4	for	for	ADP
admet-547	52	5	small	small	ADJ
admet-547	52	6	molecules	molecule	NOUN
admet-547	52	7	[	[	X
admet-547	52	8	13	13	NUM
admet-547	52	9	]	]	PUNCT
admet-547	52	10	have	have	AUX
admet-547	52	11	been	be	AUX
admet-547	52	12	applied	apply	VERB
admet-547	52	13	to	to	PART
admet-547	52	14	estimate	estimate	VERB
admet-547	52	15	the	the	DET
admet-547	52	16	in	in	ADP
admet-547	52	17	vivo	vivo	NOUN
admet-547	52	18	pk	pk	NOUN
admet-547	52	19	profile	profile	NOUN
admet-547	52	20	of	of	ADP
admet-547	52	21	gm6	gm6	PROPN
admet-547	52	22	with	with	ADP
admet-547	52	23	special	special	ADJ
admet-547	52	24	emphasis	emphasis	NOUN
admet-547	52	25	on	on	ADP
admet-547	52	26	the	the	DET
admet-547	52	27	expected	expect	VERB
admet-547	52	28	free	free	ADJ
admet-547	52	29	tissue	tissue	NOUN
admet-547	52	30	concentration	concentration	NOUN
admet-547	52	31	.	.	PUNCT
admet-547	53	1	gm6	gm6	PROPN
admet-547	53	2	has	have	AUX
admet-547	53	3	been	be	AUX
admet-547	53	4	found	find	VERB
admet-547	53	5	to	to	PART
admet-547	53	6	have	have	VERB
admet-547	53	7	good	good	ADJ
admet-547	53	8	drug	drug	NOUN
admet-547	53	9	-	-	PUNCT
admet-547	53	10	like	like	ADJ
admet-547	53	11	properties	property	NOUN
admet-547	53	12	with	with	ADP
admet-547	53	13	an	an	DET
admet-547	53	14	estimated	estimate	VERB
admet-547	53	15	good	good	ADJ
admet-547	53	16	cellular	cellular	ADJ
admet-547	53	17	accumulation	accumulation	NOUN
admet-547	53	18	and	and	CCONJ
admet-547	53	19	tissue	tissue	NOUN
admet-547	53	20	partition	partition	NOUN
admet-547	53	21	as	as	SCONJ
admet-547	53	22	has	have	AUX
admet-547	53	23	been	be	AUX
admet-547	53	24	described	describe	VERB
admet-547	53	25	previously	previously	ADV
admet-547	53	26	[	[	X
admet-547	53	27	14	14	NUM
admet-547	53	28	]	]	PUNCT
admet-547	53	29	.	.	PUNCT
admet-547	54	1	discovery	discovery	NOUN
admet-547	54	2	of	of	ADP
admet-547	54	3	gm6	gm6	PROPN
admet-547	54	4	genervon	genervon	PROPN
admet-547	54	5	biopharmaceuticals	biopharmaceutical	NOUN
admet-547	54	6	llc	llc	PROPN
admet-547	54	7	has	have	AUX
admet-547	54	8	discovered	discover	VERB
admet-547	54	9	and	and	CCONJ
admet-547	54	10	patented	patent	VERB
admet-547	54	11	[	[	X
admet-547	54	12	9	9	NUM
admet-547	54	13	]	]	PUNCT
admet-547	54	14	several	several	ADJ
admet-547	54	15	peptides	peptide	NOUN
admet-547	54	16	.	.	PUNCT
admet-547	55	1	the	the	DET
admet-547	55	2	hypothesis	hypothesis	NOUN
admet-547	55	3	is	be	AUX
admet-547	55	4	that	that	SCONJ
admet-547	55	5	the	the	DET
admet-547	55	6	master	master	NOUN
admet-547	55	7	regulator	regulator	NOUN
admet-547	55	8	for	for	ADP
admet-547	55	9	the	the	DET
admet-547	55	10	differentiation	differentiation	NOUN
admet-547	55	11	of	of	ADP
admet-547	55	12	the	the	DET
admet-547	55	13	human	human	ADJ
admet-547	55	14	nervous	nervous	ADJ
admet-547	55	15	system	system	NOUN
admet-547	55	16	must	must	AUX
admet-547	55	17	be	be	AUX
admet-547	55	18	endogenous	endogenous	ADJ
admet-547	55	19	and	and	CCONJ
admet-547	55	20	the	the	DET
admet-547	55	21	3d	3d	NOUN
admet-547	55	22	structure	structure	NOUN
admet-547	55	23	should	should	AUX
admet-547	55	24	not	not	PART
admet-547	55	25	be	be	AUX
admet-547	55	26	modified	modify	VERB
admet-547	55	27	in	in	ADP
admet-547	55	28	order	order	NOUN
admet-547	55	29	to	to	PART
admet-547	55	30	be	be	AUX
admet-547	55	31	able	able	ADJ
admet-547	55	32	to	to	PART
admet-547	55	33	bind	bind	VERB
admet-547	55	34	to	to	ADP
admet-547	55	35	a	a	DET
admet-547	55	36	specific	specific	ADJ
admet-547	55	37	receptor	receptor	NOUN
admet-547	55	38	.	.	PUNCT
admet-547	56	1	the	the	DET
admet-547	56	2	natural	natural	ADJ
admet-547	56	3	motoneuron	motoneuron	NOUN
admet-547	56	4	trophic	trophic	ADJ
admet-547	56	5	factor	factor	NOUN
admet-547	56	6	(	(	PUNCT
admet-547	56	7	mntf	mntf	ADJ
admet-547	56	8	)	)	PUNCT
admet-547	56	9	consists	consist	VERB
admet-547	56	10	of	of	ADP
admet-547	56	11	33	33	NUM
admet-547	56	12	amino	amino	ADJ
admet-547	56	13	acids	acid	NOUN
admet-547	56	14	.	.	PUNCT
admet-547	57	1	it	it	PRON
admet-547	57	2	's	be	AUX
admet-547	57	3	smaller	small	ADJ
admet-547	57	4	analogue	analogue	NOUN
admet-547	57	5	gm6	gm6	PROPN
admet-547	57	6	which	which	PRON
admet-547	57	7	is	be	AUX
admet-547	57	8	a	a	DET
admet-547	57	9	partial	partial	ADJ
admet-547	57	10	sequence	sequence	NOUN
admet-547	57	11	of	of	ADP
admet-547	57	12	mntf	mntf	PROPN
admet-547	57	13	and	and	CCONJ
admet-547	57	14	is	be	AUX
admet-547	57	15	a	a	DET
admet-547	57	16	6	6	NUM
admet-547	57	17	amino	amino	NOUN
admet-547	57	18	acid	acid	NOUN
admet-547	57	19	cationic	cationic	ADJ
admet-547	57	20	peptide	peptide	NOUN
admet-547	57	21	.	.	PUNCT
admet-547	58	1	this	this	DET
admet-547	58	2	potential	potential	ADJ
admet-547	58	3	drug	drug	NOUN
admet-547	58	4	modelled	model	VERB
admet-547	58	5	on	on	ADP
admet-547	58	6	an	an	DET
admet-547	58	7	endogenous	endogenous	ADJ
admet-547	58	8	multi	multi	ADJ
admet-547	58	9	-	-	ADJ
admet-547	58	10	target	target	ADJ
admet-547	58	11	embryonic	embryonic	ADJ
admet-547	58	12	stage	stage	NOUN
admet-547	58	13	protein	protein	NOUN
admet-547	58	14	isolated	isolate	VERB
admet-547	58	15	from	from	ADP
admet-547	58	16	the	the	DET
admet-547	58	17	nervous	nervous	ADJ
admet-547	58	18	system	system	NOUN
admet-547	58	19	.	.	PUNCT
admet-547	59	1	it	it	PRON
admet-547	59	2	was	be	AUX
admet-547	59	3	synthesized	synthesize	VERB
admet-547	59	4	and	and	CCONJ
admet-547	59	5	then	then	ADV
admet-547	59	6	tested	test	VERB
admet-547	59	7	in	in	ADP
admet-547	59	8	the	the	DET
admet-547	59	9	sod1	sod1	NOUN
admet-547	59	10	/	/	SYM
admet-547	59	11	g93a	g93a	NOUN
admet-547	59	12	transgenic	transgenic	NOUN
admet-547	59	13	mouse	mouse	NOUN
admet-547	59	14	model	model	NOUN
admet-547	59	15	for	for	ADP
admet-547	59	16	als	al	NOUN
admet-547	59	17	,	,	PUNCT
admet-547	59	18	gm6	gm6	PROPN
admet-547	59	19	delayed	delay	VERB
admet-547	59	20	disease	disease	NOUN
admet-547	59	21	onset	onset	NOUN
admet-547	59	22	(	(	PUNCT
admet-547	59	23	27	27	NUM
admet-547	59	24	%	%	NOUN
admet-547	59	25	)	)	PUNCT
admet-547	59	26	and	and	CCONJ
admet-547	59	27	significantly	significantly	ADV
admet-547	59	28	extended	extend	VERB
admet-547	59	29	the	the	DET
admet-547	59	30	survival	survival	NOUN
admet-547	59	31	(	(	PUNCT
admet-547	59	32	30	30	NUM
admet-547	59	33	%	%	NOUN
admet-547	59	34	)	)	PUNCT
admet-547	59	35	and	and	CCONJ
admet-547	59	36	improved	improve	VERB
admet-547	59	37	motor	motor	NOUN
admet-547	59	38	function	function	NOUN
admet-547	59	39	(	(	PUNCT
admet-547	59	40	4143	4143	NUM
admet-547	59	41	%	%	NOUN
admet-547	59	42	)	)	PUNCT
admet-547	60	1	[	[	X
admet-547	60	2	15	15	NUM
admet-547	60	3	]	]	PUNCT
admet-547	60	4	.	.	PUNCT
admet-547	61	1	experimental	experimental	ADJ
admet-547	61	2	physicochemical	physicochemical	ADJ
admet-547	61	3	and	and	CCONJ
admet-547	61	4	biomimetic	biomimetic	ADJ
admet-547	61	5	property	property	NOUN
admet-547	61	6	measurements	measurement	NOUN
admet-547	61	7	–	–	PUNCT
admet-547	61	8	estimating	estimate	VERB
admet-547	61	9	in	in	ADP
admet-547	61	10	vivo	vivo	ADJ
admet-547	61	11	distribution	distribution	NOUN
admet-547	61	12	of	of	ADP
admet-547	61	13	gm6	gm6	PROPN
admet-547	61	14	all	all	DET
admet-547	61	15	high	high	ADJ
admet-547	61	16	-	-	PUNCT
admet-547	61	17	performance	performance	NOUN
admet-547	61	18	liquid	liquid	ADJ
admet-547	61	19	chromatography	chromatography	NOUN
admet-547	61	20	(	(	PUNCT
admet-547	61	21	hplc	hplc	PROPN
admet-547	61	22	)	)	PUNCT
admet-547	61	23	measurement	measurement	NOUN
admet-547	61	24	were	be	AUX
admet-547	61	25	performed	perform	VERB
admet-547	61	26	on	on	ADP
admet-547	61	27	an	an	DET
admet-547	61	28	agilent	agilent	PROPN
admet-547	61	29	100	100	NUM
admet-547	61	30	equipped	equip	VERB
admet-547	61	31	with	with	ADP
admet-547	61	32	an	an	DET
admet-547	61	33	ultraviolet	ultraviolet	ADJ
admet-547	61	34	diode	diode	NOUN
admet-547	61	35	array	array	NOUN
admet-547	61	36	detector	detector	NOUN
admet-547	61	37	(	(	PUNCT
admet-547	61	38	uv	uv	NOUN
admet-547	61	39	-	-	PUNCT
admet-547	61	40	dad	dad	NOUN
admet-547	61	41	)	)	PUNCT
admet-547	61	42	.	.	PUNCT
admet-547	62	1	the	the	DET
admet-547	62	2	reversed	reverse	VERB
admet-547	62	3	phase	phase	NOUN
admet-547	62	4	fast	fast	ADJ
admet-547	62	5	gradient	gradient	NOUN
admet-547	62	6	retention	retention	NOUN
admet-547	62	7	times	time	NOUN
admet-547	62	8	have	have	AUX
admet-547	62	9	been	be	AUX
admet-547	62	10	measured	measure	VERB
admet-547	62	11	using	use	VERB
admet-547	62	12	a	a	DET
admet-547	62	13	gemini	gemini	NOUN
admet-547	62	14	nt	nt	PROPN
admet-547	62	15	c-18	c-18	PROPN
admet-547	62	16	column	column	NOUN
admet-547	62	17	with	with	ADP
admet-547	62	18	the	the	DET
admet-547	62	19	dimensions	dimension	NOUN
admet-547	62	20	of	of	ADP
admet-547	62	21	50	50	NUM
admet-547	62	22	x	x	SYM
admet-547	62	23	3	3	NUM
admet-547	62	24	mm	mm	NOUN
admet-547	62	25	,	,	PUNCT
admet-547	62	26	particle	particle	NOUN
admet-547	62	27	size	size	NOUN
admet-547	62	28	5	5	NUM
admet-547	62	29	µm	µm	NOUN
admet-547	62	30	with	with	ADP
admet-547	62	31	a	a	DET
admet-547	62	32	110	110	NUM
admet-547	62	33	å	å	PRON
admet-547	62	34	pore	pore	ADJ
admet-547	62	35	size	size	NOUN
admet-547	62	36	(	(	PUNCT
admet-547	62	37	phenomenex	phenomenex	ADV
admet-547	62	38	uk	uk	PROPN
admet-547	62	39	)	)	PUNCT
admet-547	62	40	.	.	PUNCT
admet-547	63	1	the	the	DET
admet-547	63	2	starting	start	VERB
admet-547	63	3	mobile	mobile	ADJ
admet-547	63	4	phase	phase	NOUN
admet-547	63	5	was	be	AUX
admet-547	63	6	ph	ph	VERB
admet-547	63	7	2.6	2.6	NUM
admet-547	63	8	0.01	0.01	NUM
admet-547	63	9	m	m	NOUN
admet-547	63	10	formic	formic	ADJ
admet-547	63	11	acid	acid	NOUN
admet-547	63	12	for	for	ADP
admet-547	63	13	low	low	ADJ
admet-547	63	14	ph	ph	ADJ
admet-547	63	15	lipophilicity	lipophilicity	NOUN
admet-547	63	16	,	,	PUNCT
admet-547	63	17	50	50	NUM
admet-547	63	18	mm	mm	NOUN
admet-547	63	19	ammonium	ammonium	NOUN
admet-547	63	20	acetate	acetate	NOUN
admet-547	63	21	buffers	buffer	NOUN
admet-547	63	22	with	with	ADP
admet-547	63	23	ph	ph	PROPN
admet-547	63	24	adjusted	adjust	VERB
admet-547	63	25	to	to	ADP
admet-547	63	26	7.4	7.4	NUM
admet-547	63	27	and	and	CCONJ
admet-547	63	28	10.5	10.5	NUM
admet-547	63	29	by	by	ADP
admet-547	63	30	concentrated	concentrated	ADJ
admet-547	63	31	ammonia	ammonia	NOUN
admet-547	63	32	solution	solution	NOUN
admet-547	63	33	for	for	ADP
admet-547	63	34	neutral	neutral	ADJ
admet-547	63	35	and	and	CCONJ
admet-547	63	36	basic	basic	ADJ
admet-547	63	37	ph	ph	ADJ
admet-547	63	38	lipophilicity	lipophilicity	NOUN
admet-547	63	39	measurements	measurement	NOUN
admet-547	63	40	respectively	respectively	ADV
admet-547	63	41	.	.	PUNCT
admet-547	64	1	all	all	DET
admet-547	64	2	reagents	reagent	NOUN
admet-547	64	3	were	be	AUX
admet-547	64	4	hplc	hplc	NOUN
admet-547	64	5	grade	grade	NOUN
admet-547	64	6	obtained	obtain	VERB
admet-547	64	7	from	from	ADP
admet-547	64	8	honeywell	honeywell	PROPN
admet-547	64	9	/	/	SYM
admet-547	64	10	sigma	sigma	PROPN
admet-547	64	11	-	-	PUNCT
admet-547	64	12	aldrich	aldrich	PROPN
admet-547	64	13	,	,	PUNCT
admet-547	64	14	germany	germany	PROPN
admet-547	64	15	.	.	PUNCT
admet-547	65	1	a	a	DET
admet-547	65	2	1.00	1.00	NUM
admet-547	65	3	ml	ml	NOUN
admet-547	65	4	/	/	SYM
admet-547	65	5	min	min	NOUN
admet-547	65	6	flow	flow	NOUN
admet-547	65	7	rate	rate	NOUN
admet-547	65	8	was	be	AUX
admet-547	65	9	applied	apply	VERB
admet-547	65	10	.	.	PUNCT
admet-547	66	1	the	the	DET
admet-547	66	2	acetonitrile	acetonitrile	ADJ
admet-547	66	3	gradient	gradient	NOUN
admet-547	66	4	was	be	AUX
admet-547	66	5	admet	admet	PROPN
admet-547	66	6	&	&	CCONJ
admet-547	66	7	dmpk	dmpk	PROPN
admet-547	66	8	6(2	6(2	NUM
admet-547	66	9	)	)	PUNCT
admet-547	66	10	(	(	PUNCT
admet-547	66	11	2018	2018	NUM
admet-547	66	12	)	)	PUNCT
admet-547	66	13	176	176	NUM
admet-547	66	14	-	-	SYM
admet-547	66	15	189	189	NUM
admet-547	66	16	in	in	ADP
admet-547	66	17	vitro	vitro	X
admet-547	66	18	and	and	CCONJ
admet-547	66	19	in	in	ADP
admet-547	66	20	vivo	vivo	ADJ
admet-547	66	21	characterization	characterization	NOUN
admet-547	66	22	of	of	ADP
admet-547	66	23	gm6	gm6	PROPN
admet-547	66	24	doi	doi	NOUN
admet-547	66	25	:	:	PUNCT
admet-547	66	26	10.5599	10.5599	NUM
admet-547	66	27	/	/	SYM
admet-547	66	28	admet.547	admet.547	NOUN
admet-547	66	29	179	179	NUM
admet-547	66	30	from	from	ADP
admet-547	66	31	0	0	NUM
admet-547	66	32	to	to	PART
admet-547	66	33	100	100	NUM
admet-547	66	34	%	%	NOUN
admet-547	66	35	from	from	ADP
admet-547	66	36	0	0	NUM
admet-547	66	37	to	to	ADP
admet-547	66	38	3.5	3.5	NUM
admet-547	66	39	min	min	NOUN
admet-547	66	40	then	then	ADV
admet-547	66	41	100	100	NUM
admet-547	66	42	%	%	NOUN
admet-547	66	43	acetonitrile	acetonitrile	NOUN
admet-547	66	44	was	be	AUX
admet-547	66	45	kept	keep	VERB
admet-547	66	46	until	until	ADP
admet-547	66	47	4.5	4.5	NUM
admet-547	66	48	min	min	NOUN
admet-547	66	49	and	and	CCONJ
admet-547	66	50	then	then	ADV
admet-547	66	51	returned	return	VERB
admet-547	66	52	to	to	ADP
admet-547	66	53	0	0	NUM
admet-547	66	54	%	%	NOUN
admet-547	66	55	at	at	ADP
admet-547	66	56	4.7	4.7	NUM
admet-547	66	57	min	min	NOUN
admet-547	66	58	.	.	PUNCT
admet-547	67	1	the	the	DET
admet-547	67	2	run	run	NOUN
admet-547	67	3	time	time	NOUN
admet-547	67	4	was	be	AUX
admet-547	67	5	6	6	NUM
admet-547	67	6	min	min	NOUN
admet-547	67	7	.	.	PROPN
admet-547	67	8	hplc	hplc	PROPN
admet-547	67	9	grade	grade	NOUN
admet-547	67	10	water	water	NOUN
admet-547	67	11	and	and	CCONJ
admet-547	67	12	acetonitrile	acetonitrile	NOUN
admet-547	67	13	were	be	AUX
admet-547	67	14	obtained	obtain	VERB
admet-547	67	15	from	from	ADP
admet-547	67	16	rathburn	rathburn	PROPN
admet-547	67	17	chemicals	chemicals	PROPN
admet-547	67	18	ltd	ltd	PROPN
admet-547	67	19	,	,	PUNCT
admet-547	67	20	walkerburn	walkerburn	NOUN
admet-547	67	21	,	,	PUNCT
admet-547	67	22	uk	uk	PROPN
admet-547	67	23	.	.	PUNCT
admet-547	68	1	the	the	DET
admet-547	68	2	gradient	gradient	ADJ
admet-547	68	3	retention	retention	NOUN
admet-547	68	4	times	time	NOUN
admet-547	68	5	were	be	AUX
admet-547	68	6	standardized	standardize	VERB
admet-547	68	7	using	use	VERB
admet-547	68	8	the	the	DET
admet-547	68	9	valko	valko	ADJ
admet-547	68	10	test	test	NOUN
admet-547	68	11	mixture	mixture	NOUN
admet-547	68	12	and	and	CCONJ
admet-547	68	13	the	the	DET
admet-547	68	14	chromatographic	chromatographic	ADJ
admet-547	68	15	hydrophobicity	hydrophobicity	NOUN
admet-547	68	16	index	index	NOUN
admet-547	68	17	(	(	PUNCT
admet-547	68	18	chi	chi	NOUN
admet-547	68	19	)	)	PUNCT
admet-547	68	20	values	value	NOUN
admet-547	68	21	as	as	SCONJ
admet-547	68	22	described	describe	VERB
admet-547	68	23	previously	previously	ADV
admet-547	68	24	[	[	X
admet-547	68	25	13,16	13,16	NUM
admet-547	68	26	]	]	PUNCT
admet-547	68	27	.	.	PUNCT
admet-547	69	1	the	the	DET
admet-547	69	2	chi	chi	PROPN
admet-547	69	3	values	value	NOUN
admet-547	69	4	were	be	AUX
admet-547	69	5	converted	convert	VERB
admet-547	69	6	to	to	ADP
admet-547	69	7	the	the	DET
admet-547	69	8	octanol	octanol	NOUN
admet-547	69	9	/	/	SYM
admet-547	69	10	water	water	NOUN
admet-547	69	11	log	log	NOUN
admet-547	69	12	d	d	NOUN
admet-547	69	13	scale	scale	NOUN
admet-547	69	14	using	use	VERB
admet-547	69	15	equation	equation	NOUN
admet-547	69	16	1	1	NUM
admet-547	69	17	.	.	PUNCT
admet-547	70	1	chi	chi	PROPN
admet-547	70	2	log	log	PROPN
admet-547	70	3	d	d	NOUN
admet-547	70	4	=	=	SYM
admet-547	70	5	0.0525	0.0525	NUM
admet-547	70	6	chi	chi	NOUN
admet-547	70	7	–	–	PUNCT
admet-547	70	8	1.467	1.467	NUM
admet-547	70	9	(	(	PUNCT
admet-547	70	10	1	1	NUM
admet-547	70	11	)	)	PUNCT
admet-547	70	12	in	in	ADP
admet-547	70	13	this	this	DET
admet-547	70	14	way	way	NOUN
admet-547	70	15	,	,	PUNCT
admet-547	70	16	the	the	DET
admet-547	70	17	peptides	peptide	NOUN
admet-547	70	18	lipophilicity	lipophilicity	NOUN
admet-547	70	19	can	can	AUX
admet-547	70	20	be	be	AUX
admet-547	70	21	compared	compare	VERB
admet-547	70	22	to	to	ADP
admet-547	70	23	their	their	PRON
admet-547	70	24	octanol	octanol	NOUN
admet-547	70	25	/	/	SYM
admet-547	70	26	water	water	NOUN
admet-547	70	27	lipophilicity	lipophilicity	NOUN
admet-547	70	28	.	.	PUNCT
admet-547	71	1	measurements	measurement	NOUN
admet-547	71	2	of	of	ADP
admet-547	71	3	membrane	membrane	NOUN
admet-547	71	4	binding	binding	NOUN
admet-547	71	5	using	use	VERB
admet-547	71	6	immobilized	immobilized	ADJ
admet-547	71	7	artificial	artificial	ADJ
admet-547	71	8	membrane	membrane	NOUN
admet-547	71	9	(	(	PUNCT
admet-547	71	10	iam	iam	PROPN
admet-547	71	11	)	)	PUNCT
admet-547	71	12	chromatography	chromatography	NOUN
admet-547	71	13	for	for	ADP
admet-547	71	14	the	the	DET
admet-547	71	15	measurements	measurement	NOUN
admet-547	71	16	of	of	ADP
admet-547	71	17	gm6	gm6	PROPN
admet-547	71	18	interactions	interaction	NOUN
admet-547	71	19	with	with	ADP
admet-547	71	20	phospholipids	phospholipid	NOUN
admet-547	71	21	,	,	PUNCT
admet-547	71	22	the	the	DET
admet-547	71	23	gradient	gradient	NOUN
admet-547	71	24	retention	retention	NOUN
admet-547	71	25	times	time	NOUN
admet-547	71	26	have	have	AUX
admet-547	71	27	been	be	AUX
admet-547	71	28	measured	measure	VERB
admet-547	71	29	using	use	VERB
admet-547	71	30	an	an	DET
admet-547	71	31	iam.pc.dd2	iam.pc.dd2	PROPN
admet-547	71	32	100x4.6	100x4.6	NUM
admet-547	71	33	mm	mm	PROPN
admet-547	71	34	column	column	NOUN
admet-547	71	35	with	with	ADP
admet-547	71	36	10	10	NUM
admet-547	71	37	µm	µm	ADP
admet-547	71	38	diameter	diameter	NOUN
admet-547	71	39	and	and	CCONJ
admet-547	71	40	300	300	NUM
admet-547	71	41	å	å	NOUN
admet-547	71	42	pore	pore	ADJ
admet-547	71	43	size	size	NOUN
admet-547	71	44	particles	particle	NOUN
admet-547	71	45	.	.	PUNCT
admet-547	72	1	the	the	DET
admet-547	72	2	starting	start	VERB
admet-547	72	3	mobile	mobile	ADJ
admet-547	72	4	phase	phase	NOUN
admet-547	72	5	was	be	AUX
admet-547	72	6	50	50	NUM
admet-547	72	7	mm	mm	NOUN
admet-547	72	8	ammonium	ammonium	NOUN
admet-547	72	9	acetate	acetate	NOUN
admet-547	72	10	with	with	ADP
admet-547	72	11	the	the	DET
admet-547	72	12	ph	ph	NOUN
admet-547	72	13	adjusted	adjust	VERB
admet-547	72	14	to	to	ADP
admet-547	72	15	7.4	7.4	NUM
admet-547	72	16	.	.	PUNCT
admet-547	73	1	the	the	DET
admet-547	73	2	acetonitrile	acetonitrile	ADJ
admet-547	73	3	gradient	gradient	NOUN
admet-547	73	4	was	be	AUX
admet-547	73	5	applied	apply	VERB
admet-547	73	6	from	from	ADP
admet-547	73	7	0	0	NUM
admet-547	73	8	to	to	PART
admet-547	73	9	90	90	NUM
admet-547	73	10	%	%	NOUN
admet-547	73	11	from	from	ADP
admet-547	73	12	0	0	NUM
admet-547	73	13	to	to	ADP
admet-547	73	14	4.75	4.75	NUM
admet-547	73	15	min	min	NOUN
admet-547	73	16	and	and	CCONJ
admet-547	73	17	kept	keep	VERB
admet-547	73	18	at	at	ADP
admet-547	73	19	90	90	NUM
admet-547	73	20	%	%	NOUN
admet-547	73	21	until	until	ADP
admet-547	73	22	5.25	5.25	NUM
admet-547	73	23	min	min	NOUN
admet-547	73	24	.	.	PROPN
admet-547	73	25	from	from	ADP
admet-547	73	26	5.25	5.25	NUM
admet-547	73	27	to	to	ADP
admet-547	73	28	5.5	5.5	NUM
admet-547	73	29	min	min	NOUN
admet-547	73	30	the	the	DET
admet-547	73	31	acetonitrile	acetonitrile	ADJ
admet-547	73	32	concentration	concentration	NOUN
admet-547	73	33	was	be	AUX
admet-547	73	34	dropped	drop	VERB
admet-547	73	35	to	to	ADP
admet-547	73	36	0	0	NUM
admet-547	73	37	%	%	NOUN
admet-547	73	38	.	.	PUNCT
admet-547	74	1	the	the	DET
admet-547	74	2	mobile	mobile	ADJ
admet-547	74	3	phase	phase	NOUN
admet-547	74	4	flow	flow	NOUN
admet-547	74	5	rate	rate	NOUN
admet-547	74	6	was	be	AUX
admet-547	74	7	1.5	1.5	NUM
admet-547	74	8	ml	ml	NOUN
admet-547	74	9	/	/	SYM
admet-547	74	10	min	min	NOUN
admet-547	74	11	and	and	CCONJ
admet-547	74	12	the	the	DET
admet-547	74	13	run	run	NOUN
admet-547	74	14	time	time	NOUN
admet-547	74	15	was	be	AUX
admet-547	74	16	6	6	NUM
admet-547	74	17	min	min	NOUN
admet-547	74	18	.	.	PUNCT
admet-547	75	1	the	the	DET
admet-547	75	2	retention	retention	NOUN
admet-547	75	3	times	time	NOUN
admet-547	75	4	were	be	AUX
admet-547	75	5	standardized	standardize	VERB
admet-547	75	6	using	use	VERB
admet-547	75	7	the	the	DET
admet-547	75	8	iam	iam	PROPN
admet-547	75	9	calibration	calibration	NOUN
admet-547	75	10	mixture	mixture	NOUN
admet-547	75	11	as	as	SCONJ
admet-547	75	12	described	describe	VERB
admet-547	75	13	previously	previously	ADV
admet-547	75	14	[	[	X
admet-547	75	15	17	17	NUM
admet-547	75	16	]	]	X
admet-547	75	17	(	(	PUNCT
admet-547	75	18	equation	equation	NOUN
admet-547	75	19	2	2	NUM
admet-547	75	20	)	)	PUNCT
admet-547	75	21	.	.	PUNCT
admet-547	76	1	log	log	VERB
admet-547	76	2	kiam	kiam	PROPN
admet-547	77	1	=	=	PUNCT
admet-547	77	2	0.29*exp(0.046	0.29*exp(0.046	NOUN
admet-547	77	3	chi	chi	NOUN
admet-547	77	4	iam+0.42	iam+0.42	PROPN
admet-547	77	5	)	)	PUNCT
admet-547	77	6	+	+	CCONJ
admet-547	77	7	0.70	0.70	NUM
admet-547	77	8	(	(	PUNCT
admet-547	77	9	2	2	NUM
admet-547	77	10	)	)	PUNCT
admet-547	77	11	the	the	DET
admet-547	77	12	log	log	NOUN
admet-547	77	13	kiam	kiam	PROPN
admet-547	77	14	values	value	NOUN
admet-547	77	15	express	express	VERB
admet-547	77	16	the	the	DET
admet-547	77	17	membrane	membrane	NOUN
admet-547	77	18	partition	partition	NOUN
admet-547	77	19	comparable	comparable	ADJ
admet-547	77	20	to	to	ADP
admet-547	77	21	the	the	DET
admet-547	77	22	octanol	octanol	NOUN
admet-547	77	23	/	/	SYM
admet-547	77	24	water	water	NOUN
admet-547	77	25	lipophilicity	lipophilicity	NOUN
admet-547	77	26	.	.	PUNCT
admet-547	78	1	protein	protein	NOUN
admet-547	78	2	binding	bind	VERB
admet-547	78	3	measurements	measurement	NOUN
admet-547	78	4	using	use	VERB
admet-547	78	5	biomimetic	biomimetic	ADJ
admet-547	78	6	protein	protein	NOUN
admet-547	78	7	stationary	stationary	ADJ
admet-547	78	8	phases	phase	NOUN
admet-547	78	9	the	the	DET
admet-547	78	10	peptides	peptide	NOUN
admet-547	78	11	interactions	interaction	NOUN
admet-547	78	12	with	with	ADP
admet-547	78	13	human	human	ADJ
admet-547	78	14	serum	serum	NOUN
admet-547	78	15	albumin	albumin	PROPN
admet-547	78	16	(	(	PUNCT
admet-547	78	17	hsa	hsa	PROPN
admet-547	78	18	)	)	PUNCT
admet-547	78	19	and	and	CCONJ
admet-547	78	20	alpha-1	alpha-1	NOUN
admet-547	78	21	-	-	PUNCT
admet-547	78	22	acid	acid	NOUN
admet-547	78	23	-	-	PUNCT
admet-547	78	24	glycoprotein	glycoprotein	NOUN
admet-547	78	25	(	(	PUNCT
admet-547	78	26	agp	agp	NOUN
admet-547	78	27	)	)	PUNCT
admet-547	78	28	have	have	AUX
admet-547	78	29	been	be	AUX
admet-547	78	30	measured	measure	VERB
admet-547	78	31	using	use	VERB
admet-547	78	32	commercially	commercially	ADV
admet-547	78	33	available	available	ADJ
admet-547	78	34	chemically	chemically	ADV
admet-547	78	35	bonded	bond	VERB
admet-547	78	36	hsa	hsa	PROPN
admet-547	78	37	(	(	PUNCT
admet-547	78	38	chiralpak	chiralpak	NOUN
admet-547	78	39	-	-	PUNCT
admet-547	78	40	hsa	hsa	NOUN
admet-547	78	41	)	)	PUNCT
admet-547	78	42	and	and	CCONJ
admet-547	78	43	agp	agp	PROPN
admet-547	78	44	(	(	PUNCT
admet-547	78	45	chiralpakagp	chiralpakagp	NOUN
admet-547	78	46	)	)	PUNCT
admet-547	78	47	hplc	hplc	NOUN
admet-547	78	48	columns	column	NOUN
admet-547	78	49	with	with	ADP
admet-547	78	50	the	the	DET
admet-547	78	51	dimensions	dimension	NOUN
admet-547	78	52	of	of	ADP
admet-547	78	53	50	50	NUM
admet-547	78	54	x	x	SYM
admet-547	78	55	3	3	NUM
admet-547	78	56	mm	mm	NOUN
admet-547	78	57	with	with	ADP
admet-547	78	58	a	a	DET
admet-547	78	59	5	5	NUM
admet-547	78	60	µm	µm	NOUN
admet-547	78	61	particle	particle	NOUN
admet-547	78	62	size	size	NOUN
admet-547	78	63	obtained	obtain	VERB
admet-547	78	64	from	from	ADP
admet-547	78	65	hichrom	hichrom	ADP
admet-547	78	66	ltd	ltd	PROPN
admet-547	78	67	,	,	PUNCT
admet-547	78	68	reading	reading	NOUN
admet-547	78	69	,	,	PUNCT
admet-547	78	70	uk	uk	PROPN
admet-547	78	71	.	.	PUNCT
admet-547	79	1	the	the	DET
admet-547	79	2	mobile	mobile	ADJ
admet-547	79	3	phase	phase	NOUN
admet-547	79	4	was	be	AUX
admet-547	79	5	50	50	NUM
admet-547	79	6	mm	mm	NOUN
admet-547	79	7	ammonium	ammonium	NOUN
admet-547	79	8	acetate	acetate	NOUN
admet-547	79	9	with	with	ADP
admet-547	79	10	the	the	DET
admet-547	79	11	ph	ph	NOUN
admet-547	79	12	adjusted	adjust	VERB
admet-547	79	13	to	to	ADP
admet-547	79	14	7.4	7.4	NUM
admet-547	79	15	.	.	PUNCT
admet-547	80	1	an	an	DET
admet-547	80	2	isopropanol	isopropanol	NOUN
admet-547	80	3	gradient	gradient	NOUN
admet-547	80	4	(	(	PUNCT
admet-547	80	5	hplc	hplc	NOUN
admet-547	80	6	grade	grade	NOUN
admet-547	80	7	,	,	PUNCT
admet-547	80	8	rathburn	rathburn	NOUN
admet-547	80	9	chemicals	chemical	NOUN
admet-547	80	10	,	,	PUNCT
admet-547	80	11	walkerburn	walkerburn	NOUN
admet-547	80	12	,	,	PUNCT
admet-547	80	13	uk	uk	PROPN
admet-547	80	14	)	)	PUNCT
admet-547	80	15	was	be	AUX
admet-547	80	16	used	use	VERB
admet-547	80	17	from	from	ADP
admet-547	80	18	0	0	NUM
admet-547	80	19	to	to	ADP
admet-547	80	20	35	35	NUM
admet-547	80	21	%	%	NOUN
admet-547	80	22	from	from	ADP
admet-547	80	23	0	0	NUM
admet-547	80	24	to	to	ADP
admet-547	80	25	3.5	3.5	NUM
admet-547	80	26	min	min	NOUN
admet-547	80	27	with	with	ADP
admet-547	80	28	a	a	DET
admet-547	80	29	flow	flow	NOUN
admet-547	80	30	rate	rate	NOUN
admet-547	80	31	of	of	ADP
admet-547	80	32	1.5	1.5	NUM
admet-547	80	33	ml	ml	NOUN
admet-547	80	34	/	/	SYM
admet-547	80	35	min	min	NOUN
admet-547	80	36	.	.	PUNCT
admet-547	80	37	the	the	DET
admet-547	80	38	35	35	NUM
admet-547	80	39	%	%	NOUN
admet-547	80	40	iso	iso	NOUN
admet-547	80	41	-	-	PUNCT
admet-547	80	42	propanol	propanol	ADJ
admet-547	80	43	mobile	mobile	ADJ
admet-547	80	44	phase	phase	NOUN
admet-547	80	45	was	be	AUX
admet-547	80	46	run	run	VERB
admet-547	80	47	till	till	SCONJ
admet-547	80	48	4.5	4.5	NUM
admet-547	80	49	min	min	NOUN
admet-547	80	50	and	and	CCONJ
admet-547	80	51	then	then	ADV
admet-547	80	52	back	back	ADV
admet-547	80	53	to	to	ADP
admet-547	80	54	0	0	NUM
admet-547	80	55	%	%	NOUN
admet-547	80	56	within	within	ADP
admet-547	80	57	0.2	0.2	NUM
admet-547	80	58	min	min	NOUN
admet-547	80	59	.	.	PUNCT
admet-547	81	1	the	the	DET
admet-547	81	2	run	run	NOUN
admet-547	81	3	time	time	NOUN
admet-547	81	4	was	be	AUX
admet-547	81	5	6	6	NUM
admet-547	81	6	min	min	NOUN
admet-547	81	7	to	to	PART
admet-547	81	8	allow	allow	VERB
admet-547	81	9	re	re	VERB
admet-547	81	10	-	-	NOUN
admet-547	81	11	equilibrate	equilibrate	NOUN
admet-547	81	12	of	of	ADP
admet-547	81	13	the	the	DET
admet-547	81	14	protein	protein	NOUN
admet-547	81	15	phase	phase	NOUN
admet-547	81	16	with	with	ADP
admet-547	81	17	the	the	DET
admet-547	81	18	buffer	buffer	NOUN
admet-547	81	19	.	.	PUNCT
admet-547	82	1	the	the	DET
admet-547	82	2	retention	retention	NOUN
admet-547	82	3	times	time	NOUN
admet-547	82	4	were	be	AUX
admet-547	82	5	standardized	standardize	VERB
admet-547	82	6	using	use	VERB
admet-547	82	7	the	the	DET
admet-547	82	8	calibration	calibration	NOUN
admet-547	82	9	set	set	NOUN
admet-547	82	10	of	of	ADP
admet-547	82	11	compounds	compound	NOUN
admet-547	82	12	as	as	SCONJ
admet-547	82	13	described	describe	VERB
admet-547	82	14	previously	previously	ADV
admet-547	82	15	.	.	PUNCT
admet-547	83	1	using	use	VERB
admet-547	83	2	the	the	DET
admet-547	83	3	slope	slope	NOUN
admet-547	83	4	and	and	CCONJ
admet-547	83	5	intercept	intercept	NOUN
admet-547	83	6	values	value	NOUN
admet-547	83	7	from	from	ADP
admet-547	83	8	the	the	DET
admet-547	83	9	calibration	calibration	NOUN
admet-547	83	10	line	line	NOUN
admet-547	83	11	the	the	DET
admet-547	83	12	logarithmic	logarithmic	ADJ
admet-547	83	13	retention	retention	NOUN
admet-547	83	14	times	time	NOUN
admet-547	83	15	were	be	AUX
admet-547	83	16	converted	convert	VERB
admet-547	83	17	to	to	PART
admet-547	83	18	log	log	VERB
admet-547	83	19	k	k	PROPN
admet-547	83	20	values	value	NOUN
admet-547	83	21	that	that	PRON
admet-547	83	22	can	can	AUX
admet-547	83	23	be	be	AUX
admet-547	83	24	converted	convert	VERB
admet-547	83	25	to	to	ADP
admet-547	83	26	%	%	NOUN
admet-547	83	27	binding	bind	VERB
admet-547	83	28	values	value	NOUN
admet-547	83	29	(	(	PUNCT
admet-547	83	30	%	%	INTJ
admet-547	83	31	hsa	hsa	NOUN
admet-547	83	32	and	and	CCONJ
admet-547	83	33	%	%	INTJ
admet-547	83	34	agp	agp	NOUN
admet-547	83	35	)	)	PUNCT
admet-547	83	36	using	use	VERB
admet-547	83	37	equation	equation	NOUN
admet-547	83	38	3	3	NUM
admet-547	83	39	[	[	X
admet-547	83	40	18	18	NUM
admet-547	83	41	]	]	PUNCT
admet-547	83	42	.	.	PUNCT
admet-547	84	1	log	log	VERB
admet-547	84	2	log	log	NOUN
admet-547	84	3	101	101	NUM
admet-547	84	4	10	10	NUM
admet-547	84	5	%	%	NOUN
admet-547	84	6	bound	bind	VERB
admet-547	84	7	1	1	NUM
admet-547	84	8	10	10	NUM
admet-547	85	1	k	k	NOUN
admet-547	85	2	k	k	PROPN
admet-547	85	3			PROPN
admet-547	85	4			PROPN
admet-547	85	5			PUNCT
admet-547	85	6	(	(	PUNCT
admet-547	85	7	3	3	NUM
admet-547	85	8	)	)	PUNCT
admet-547	85	9	in	in	ADP
admet-547	85	10	order	order	NOUN
admet-547	85	11	to	to	PART
admet-547	85	12	be	be	AUX
admet-547	85	13	able	able	ADJ
admet-547	85	14	to	to	PART
admet-547	85	15	estimate	estimate	VERB
admet-547	85	16	the	the	DET
admet-547	85	17	in	in	ADP
admet-547	85	18	vivo	vivo	ADJ
admet-547	85	19	distribution	distribution	NOUN
admet-547	85	20	,	,	PUNCT
admet-547	85	21	cell	cell	NOUN
admet-547	85	22	penetration	penetration	NOUN
admet-547	85	23	,	,	PUNCT
admet-547	85	24	cell	cell	NOUN
admet-547	85	25	membrane	membrane	NOUN
admet-547	85	26	affinity	affinity	NOUN
admet-547	85	27	and	and	CCONJ
admet-547	85	28	plasma	plasma	NOUN
admet-547	85	29	protein	protein	NOUN
admet-547	85	30	binding	bind	VERB
admet-547	85	31	biomimetic	biomimetic	ADJ
admet-547	85	32	hplc	hplc	NOUN
admet-547	85	33	characterization	characterization	NOUN
admet-547	85	34	of	of	ADP
admet-547	85	35	gm6	gm6	PROPN
admet-547	85	36	were	be	AUX
admet-547	85	37	carried	carry	VERB
admet-547	85	38	out	out	ADP
admet-547	85	39	using	use	VERB
admet-547	85	40	the	the	DET
admet-547	85	41	methods	method	NOUN
admet-547	85	42	described	describe	VERB
admet-547	85	43	earlier	early	ADV
admet-547	85	44	[	[	X
admet-547	85	45	13,14,19	13,14,19	NUM
admet-547	85	46	]	]	PUNCT
admet-547	85	47	.	.	PUNCT
admet-547	86	1	the	the	DET
admet-547	86	2	in	in	ADP
admet-547	86	3	vivo	vivo	ADJ
admet-547	86	4	distribution	distribution	NOUN
admet-547	86	5	behaviour	behaviour	NOUN
admet-547	86	6	of	of	ADP
admet-547	86	7	gm6	gm6	PROPN
admet-547	86	8	has	have	AUX
admet-547	86	9	been	be	AUX
admet-547	86	10	estimated	estimate	VERB
admet-547	86	11	on	on	ADP
admet-547	86	12	c-18	c-18	PROPN
admet-547	86	13	,	,	PUNCT
admet-547	86	14	iam	iam	PROPN
admet-547	86	15	,	,	PUNCT
admet-547	86	16	hsa	hsa	PROPN
admet-547	86	17	and	and	CCONJ
admet-547	86	18	agp	agp	NOUN
admet-547	86	19	stationary	stationary	ADJ
admet-547	86	20	phases	phase	NOUN
admet-547	86	21	based	base	VERB
admet-547	86	22	on	on	ADP
admet-547	86	23	the	the	DET
admet-547	86	24	measured	measure	VERB
admet-547	86	25	generic	generic	ADJ
admet-547	86	26	gradient	gradient	NOUN
admet-547	86	27	retention	retention	NOUN
admet-547	86	28	times	time	NOUN
admet-547	86	29	described	describe	VERB
admet-547	86	30	above	above	ADV
admet-547	86	31	.	.	PUNCT
admet-547	87	1	the	the	DET
admet-547	87	2	model	model	NOUN
admet-547	87	3	equations	equation	NOUN
admet-547	87	4	with	with	ADP
admet-547	87	5	the	the	DET
admet-547	87	6	source	source	NOUN
admet-547	87	7	references	reference	NOUN
admet-547	87	8	are	be	AUX
admet-547	87	9	listed	list	VERB
admet-547	87	10	in	in	ADP
admet-547	87	11	table	table	NOUN
admet-547	87	12	1	1	NUM
admet-547	87	13	.	.	PUNCT
admet-547	87	14	stability	stability	NOUN
admet-547	87	15	measurements	measurement	NOUN
admet-547	87	16	in	in	ADP
admet-547	87	17	human	human	ADJ
admet-547	87	18	plasma	plasma	NOUN
admet-547	87	19	the	the	DET
admet-547	87	20	plasma	plasma	NOUN
admet-547	87	21	stability	stability	NOUN
admet-547	87	22	of	of	ADP
admet-547	87	23	gm6	gm6	PROPN
admet-547	87	24	has	have	AUX
admet-547	87	25	been	be	AUX
admet-547	87	26	investigated	investigate	VERB
admet-547	87	27	by	by	ADP
admet-547	87	28	using	use	VERB
admet-547	87	29	a	a	DET
admet-547	87	30	standard	standard	ADJ
admet-547	87	31	hplc	hplc	NOUN
admet-547	87	32	/	/	SYM
admet-547	87	33	ms	ms	PROPN
admet-547	87	34	/	/	SYM
admet-547	87	35	ms	ms	NOUN
admet-547	87	36	procedure	procedure	NOUN
admet-547	87	37	by	by	ADP
admet-547	87	38	frontage	frontage	PROPN
admet-547	87	39	laboratory	laboratory	PROPN
admet-547	87	40	inc	inc	PROPN
admet-547	87	41	(	(	PUNCT
admet-547	87	42	malvern	malvern	PROPN
admet-547	87	43	,	,	PUNCT
admet-547	87	44	pa	pa	PROPN
admet-547	87	45	,	,	PUNCT
admet-547	87	46	usa	usa	PROPN
admet-547	87	47	)	)	PUNCT
admet-547	87	48	.	.	PUNCT
admet-547	88	1	this	this	DET
admet-547	88	2	bioanalytical	bioanalytical	ADJ
admet-547	88	3	laboratory	laboratory	NOUN
admet-547	88	4	measured	measure	VERB
admet-547	88	5	the	the	DET
admet-547	88	6	concentration	concentration	NOUN
admet-547	88	7	of	of	ADP
admet-547	88	8	klara	klara	PROPN
admet-547	88	9	valko	valko	PROPN
admet-547	88	10	et	et	PROPN
admet-547	88	11	al	al	PROPN
admet-547	88	12	.	.	PROPN
admet-547	88	13	admet	admet	PROPN
admet-547	88	14	&	&	CCONJ
admet-547	88	15	dmpk	dmpk	PROPN
admet-547	88	16	6(2	6(2	NUM
admet-547	88	17	)	)	PUNCT
admet-547	88	18	(	(	PUNCT
admet-547	88	19	2018	2018	NUM
admet-547	88	20	)	)	PUNCT
admet-547	88	21	176	176	NUM
admet-547	88	22	-	-	SYM
admet-547	88	23	189	189	NUM
admet-547	88	24	180	180	NUM
admet-547	88	25	gm6	gm6	NOUN
admet-547	88	26	in	in	ADP
admet-547	88	27	human	human	ADJ
admet-547	88	28	plasma	plasma	NOUN
admet-547	88	29	using	use	VERB
admet-547	88	30	k2edta	k2edta	PROPN
admet-547	88	31	as	as	ADP
admet-547	88	32	the	the	DET
admet-547	88	33	anticoagulant	anticoagulant	NOUN
admet-547	88	34	.	.	PUNCT
admet-547	89	1	the	the	DET
admet-547	89	2	system	system	NOUN
admet-547	89	3	was	be	AUX
admet-547	89	4	calibrated	calibrate	VERB
admet-547	89	5	using	use	VERB
admet-547	89	6	gm6	gm6	PROPN
admet-547	89	7	in	in	ADP
admet-547	89	8	the	the	DET
admet-547	89	9	concentration	concentration	NOUN
admet-547	89	10	range	range	NOUN
admet-547	89	11	of	of	ADP
admet-547	89	12	250	250	NUM
admet-547	89	13	ng	ng	NOUN
admet-547	89	14	/	/	SYM
admet-547	89	15	ml	ml	NOUN
admet-547	89	16	to	to	ADP
admet-547	89	17	50	50	NUM
admet-547	89	18	mg	mg	NUM
admet-547	89	19	/	/	SYM
admet-547	89	20	ml	ml	NOUN
admet-547	89	21	.	.	PUNCT
admet-547	90	1	the	the	DET
admet-547	90	2	mean	mean	ADJ
admet-547	90	3	gm6	gm6	PROPN
admet-547	90	4	concentration	concentration	NOUN
admet-547	90	5	was	be	AUX
admet-547	90	6	measured	measure	VERB
admet-547	90	7	at	at	ADP
admet-547	90	8	10	10	NUM
admet-547	90	9	,	,	PUNCT
admet-547	90	10	15	15	NUM
admet-547	90	11	,	,	PUNCT
admet-547	90	12	30	30	NUM
admet-547	90	13	and	and	CCONJ
admet-547	90	14	60	60	NUM
admet-547	90	15	min	min	NOUN
admet-547	90	16	time	time	NOUN
admet-547	90	17	points	point	NOUN
admet-547	90	18	after	after	ADP
admet-547	90	19	incubation	incubation	NOUN
admet-547	90	20	.	.	PUNCT
admet-547	91	1	a	a	DET
admet-547	91	2	considerable	considerable	ADJ
admet-547	91	3	difference	difference	NOUN
admet-547	91	4	was	be	AUX
admet-547	91	5	observed	observe	VERB
admet-547	91	6	in	in	ADP
admet-547	91	7	the	the	DET
admet-547	91	8	mean	mean	ADJ
admet-547	91	9	concentration	concentration	NOUN
admet-547	91	10	of	of	ADP
admet-547	91	11	the	the	DET
admet-547	91	12	peptide	peptide	NOUN
admet-547	91	13	gm6	gm6	PROPN
admet-547	91	14	within	within	ADP
admet-547	91	15	each	each	DET
admet-547	91	16	individual	individual	ADJ
admet-547	91	17	lot	lot	NOUN
admet-547	91	18	of	of	ADP
admet-547	91	19	whole	whole	ADJ
admet-547	91	20	human	human	ADJ
admet-547	91	21	blood	blood	NOUN
admet-547	91	22	at	at	ADP
admet-547	91	23	times	time	NOUN
admet-547	91	24	10	10	NUM
admet-547	91	25	,	,	PUNCT
admet-547	91	26	15	15	NUM
admet-547	91	27	,	,	PUNCT
admet-547	91	28	30	30	NUM
admet-547	91	29	and	and	CCONJ
admet-547	91	30	60	60	NUM
admet-547	91	31	min	min	NOUN
admet-547	91	32	compared	compare	VERB
admet-547	91	33	with	with	ADP
admet-547	91	34	the	the	DET
admet-547	91	35	1	1	NUM
admet-547	91	36	minute	minute	NOUN
admet-547	91	37	time	time	NOUN
admet-547	91	38	point	point	NOUN
admet-547	91	39	,	,	PUNCT
admet-547	91	40	which	which	PRON
admet-547	91	41	indicated	indicate	VERB
admet-547	91	42	that	that	SCONJ
admet-547	91	43	in	in	ADP
admet-547	91	44	the	the	DET
admet-547	91	45	absence	absence	NOUN
admet-547	91	46	of	of	ADP
admet-547	91	47	stabilizer	stabilizer	NOUN
admet-547	91	48	,	,	PUNCT
admet-547	91	49	gm6	gm6	PROPN
admet-547	91	50	is	be	AUX
admet-547	91	51	not	not	PART
admet-547	91	52	stable	stable	ADJ
admet-547	91	53	in	in	ADP
admet-547	91	54	fresh	fresh	ADJ
admet-547	91	55	human	human	ADJ
admet-547	91	56	blood	blood	NOUN
admet-547	91	57	.	.	PUNCT
admet-547	92	1	it	it	PRON
admet-547	92	2	is	be	AUX
admet-547	92	3	worth	worth	ADJ
admet-547	92	4	mentioning	mention	VERB
admet-547	92	5	that	that	SCONJ
admet-547	92	6	in	in	ADP
admet-547	92	7	this	this	DET
admet-547	92	8	study	study	NOUN
admet-547	92	9	only	only	ADV
admet-547	92	10	the	the	DET
admet-547	92	11	intact	intact	ADJ
admet-547	92	12	gm6	gm6	PROPN
admet-547	92	13	molecule	molecule	NOUN
admet-547	92	14	concentration	concentration	NOUN
admet-547	92	15	was	be	AUX
admet-547	92	16	monitored	monitor	VERB
admet-547	92	17	.	.	PUNCT
admet-547	93	1	table	table	NOUN
admet-547	93	2	1	1	NUM
admet-547	93	3	.	.	PUNCT
admet-547	94	1	the	the	DET
admet-547	94	2	model	model	NOUN
admet-547	94	3	equations	equation	NOUN
admet-547	94	4	used	use	VERB
admet-547	94	5	to	to	PART
admet-547	94	6	derive	derive	VERB
admet-547	94	7	estimated	estimate	VERB
admet-547	94	8	in	in	ADP
admet-547	94	9	vivo	vivo	ADJ
admet-547	94	10	distribution	distribution	NOUN
admet-547	94	11	(	(	PUNCT
admet-547	94	12	log	log	VERB
admet-547	94	13	vdss	vdss	ADV
admet-547	94	14	=	=	SYM
admet-547	94	15	logarithm	logarithm	NOUN
admet-547	94	16	of	of	ADP
admet-547	94	17	the	the	DET
admet-547	94	18	volume	volume	NOUN
admet-547	94	19	of	of	ADP
admet-547	94	20	distribution	distribution	NOUN
admet-547	94	21	,	,	PUNCT
admet-547	94	22	log	log	VERB
admet-547	94	23	vdu=	vdu=	ADJ
admet-547	94	24	logarithm	logarithm	NOUN
admet-547	94	25	of	of	ADP
admet-547	94	26	the	the	DET
admet-547	94	27	unbound	unbound	NOUN
admet-547	94	28	volume	volume	NOUN
admet-547	94	29	of	of	ADP
admet-547	94	30	distribution	distribution	NOUN
admet-547	94	31	)	)	PUNCT
admet-547	94	32	,	,	PUNCT
admet-547	94	33	drug	drug	NOUN
admet-547	94	34	efficiency	efficiency	NOUN
admet-547	94	35	(	(	PUNCT
admet-547	94	36	demax	demax	NOUN
admet-547	94	37	)	)	PUNCT
admet-547	94	38	,	,	PUNCT
admet-547	94	39	brain	brain	NOUN
admet-547	94	40	tissue	tissue	NOUN
admet-547	94	41	binding	bind	VERB
admet-547	94	42	(	(	PUNCT
admet-547	94	43	log	log	NOUN
admet-547	94	44	kbtb	kbtb	NOUN
admet-547	94	45	)	)	PUNCT
admet-547	94	46	,	,	PUNCT
admet-547	94	47	fraction	fraction	NOUN
admet-547	94	48	unbound	unbound	NOUN
admet-547	94	49	in	in	ADP
admet-547	94	50	brain	brain	NOUN
admet-547	94	51	and	and	CCONJ
admet-547	94	52	plasma	plasma	NOUN
admet-547	94	53	(	(	PUNCT
admet-547	94	54	fubtb	fubtb	NOUN
admet-547	94	55	and	and	CCONJ
admet-547	94	56	fuppb	fuppb	NOUN
admet-547	94	57	)	)	PUNCT
admet-547	94	58	,	,	PUNCT
admet-547	94	59	brain	brain	NOUN
admet-547	94	60	to	to	ADP
admet-547	94	61	plasma	plasma	NOUN
admet-547	94	62	ratio	ratio	NOUN
admet-547	94	63	(	(	PUNCT
admet-547	94	64	kbb	kbb	PROPN
admet-547	94	65	)	)	PUNCT
admet-547	94	66	and	and	CCONJ
admet-547	94	67	cell	cell	NOUN
admet-547	94	68	partition	partition	NOUN
admet-547	94	69	log	log	NOUN
admet-547	94	70	kpcell	kpcell	ADJ
admet-547	94	71	)	)	PUNCT
admet-547	94	72	.	.	PUNCT
admet-547	95	1	log	log	PROPN
admet-547	95	2	kiam	kiam	PROPN
admet-547	96	1	[	[	X
admet-547	96	2	17	17	NUM
admet-547	96	3	]	]	X
admet-547	96	4	=	=	SYM
admet-547	96	5	0.29*e	0.29*e	NUM
admet-547	96	6	(	(	PUNCT
admet-547	96	7	0.026chi(iam)+0.42	0.026chi(iam)+0.42	NUM
admet-547	96	8	)	)	PUNCT
admet-547	97	1	+	+	CCONJ
admet-547	97	2	0.7	0.7	NUM
admet-547	97	3	log	log	NOUN
admet-547	97	4	kiam	kiam	PROPN
admet-547	98	1	[	[	X
admet-547	98	2	17	17	NUM
admet-547	98	3	]	]	X
admet-547	98	4	=	=	SYM
admet-547	98	5	0.046*chi(iam	0.046*chi(iam	NUM
admet-547	98	6	)	)	PUNCT
admet-547	99	1	+	+	CCONJ
admet-547	99	2	0.42	0.42	NUM
admet-547	99	3	log	log	NOUN
admet-547	99	4	khsa	khsa	NOUN
admet-547	100	1	[	[	X
admet-547	100	2	17	17	NUM
admet-547	100	3	]	]	PUNCT
admet-547	100	4	=	=	PUNCT
admet-547	100	5	e	e	X
admet-547	100	6	log	log	NOUN
admet-547	100	7	k(hsa	k(hsa	NOUN
admet-547	100	8	)	)	PUNCT
admet-547	100	9	log	log	NOUN
admet-547	100	10	khsa	khsa	NOUN
admet-547	101	1	[	[	X
admet-547	101	2	18	18	NUM
admet-547	101	3	]	]	X
admet-547	101	4	=	=	PUNCT
admet-547	101	5	log	log	NOUN
admet-547	101	6	(	(	PUNCT
admet-547	101	7	%	%	INTJ
admet-547	101	8	hsabound/(101%hsa	hsabound/(101%hsa	NOUN
admet-547	101	9	bound	bind	VERB
admet-547	101	10	)	)	PUNCT
admet-547	101	11	)	)	PUNCT
admet-547	101	12	estimated	estimate	VERB
admet-547	101	13	log	log	VERB
admet-547	101	14	vdss	vdss	ADV
admet-547	102	1	[	[	X
admet-547	102	2	17	17	NUM
admet-547	102	3	]	]	X
admet-547	102	4	=	=	SYM
admet-547	102	5	0.44*log	0.44*log	PROPN
admet-547	102	6	kiam	kiam	PROPN
admet-547	102	7	-0.22*log	-0.22*log	PROPN
admet-547	102	8	khsa	khsa	PROPN
admet-547	102	9	0.62	0.62	NUM
admet-547	102	10	estimated	estimate	VERB
admet-547	102	11	log	log	NOUN
admet-547	102	12	vdu	vdu	PROPN
admet-547	103	1	[	[	X
admet-547	103	2	20	20	NUM
admet-547	103	3	]	]	X
admet-547	103	4	=	=	SYM
admet-547	103	5	0.23*log	0.23*log	PROPN
admet-547	103	6	khsa	khsa	PROPN
admet-547	103	7	+0.43*log	+0.43*log	PROPN
admet-547	103	8	kiam	kiam	PROPN
admet-547	103	9	0.72	0.72	NUM
admet-547	103	10	demax	demax	NOUN
admet-547	103	11	[	[	X
admet-547	103	12	21	21	NUM
admet-547	103	13	]	]	X
admet-547	103	14	=	=	SYM
admet-547	103	15	100	100	NUM
admet-547	103	16	/	/	SYM
admet-547	103	17	vdu	vdu	PROPN
admet-547	103	18	log	log	NOUN
admet-547	103	19	kbtb	kbtb	NOUN
admet-547	104	1	[	[	X
admet-547	104	2	22	22	NUM
admet-547	104	3	]	]	X
admet-547	104	4	=	=	SYM
admet-547	104	5	1.29*log	1.29*log	NUM
admet-547	104	6	kiam+1.03*log	kiam+1.03*log	PROPN
admet-547	104	7	khsa	khsa	VERB
admet-547	104	8	2.37	2.37	NUM
admet-547	104	9	log	log	NOUN
admet-547	104	10	kppb	kppb	PROPN
admet-547	105	1	[	[	X
admet-547	105	2	22	22	NUM
admet-547	105	3	]	]	X
admet-547	105	4	=	=	NOUN
admet-547	105	5	0.98∗log	0.98∗log	NUM
admet-547	105	6	𝑘𝐻𝑆𝐴+0.19∗log	𝑘𝐻𝑆𝐴+0.19∗log	NUM
admet-547	105	7	𝑘𝐴𝐺𝑃+0.031∗chi	𝑘𝐴𝐺𝑃+0.031∗chi	NOUN
admet-547	105	8	log	log	NOUN
admet-547	105	9	d7.4−0.20	d7.4−0.20	NOUN
admet-547	105	10	%	%	INTJ
admet-547	105	11	btb	btb	ADP
admet-547	105	12	[	[	NOUN
admet-547	105	13	22	22	NUM
admet-547	105	14	]	]	X
admet-547	105	15	=	=	NOUN
admet-547	105	16	100	100	NUM
admet-547	105	17	*	*	SYM
admet-547	105	18	10	10	NUM
admet-547	105	19	log	log	NOUN
admet-547	105	20	kbtb	kbtb	NOUN
admet-547	105	21	/(1	/(1	PUNCT
admet-547	106	1	+	+	NOUN
admet-547	106	2	10	10	NUM
admet-547	106	3	log	log	NOUN
admet-547	106	4	kbtb	kbtb	NOUN
admet-547	106	5	)	)	PUNCT
admet-547	107	1	%	%	NOUN
admet-547	108	1	ppb	ppb	NOUN
admet-547	109	1	[	[	X
admet-547	109	2	22	22	NUM
admet-547	109	3	]	]	X
admet-547	109	4	=	=	NOUN
admet-547	109	5	100	100	NUM
admet-547	109	6	*	*	SYM
admet-547	109	7	10	10	NUM
admet-547	109	8	log	log	NOUN
admet-547	109	9	kppb/(1	kppb/(1	PROPN
admet-547	109	10	+	+	PROPN
admet-547	109	11	10	10	NUM
admet-547	109	12	log	log	NOUN
admet-547	109	13	kppb	kppb	NOUN
admet-547	109	14	)	)	PUNCT
admet-547	109	15	fu	fu	NOUN
admet-547	109	16	btb	btb	NOUN
admet-547	109	17	and	and	CCONJ
admet-547	109	18	ppb	ppb	VERB
admet-547	109	19	[	[	X
admet-547	109	20	22	22	NUM
admet-547	109	21	]	]	X
admet-547	109	22	=	=	NOUN
admet-547	109	23	(	(	PUNCT
admet-547	109	24	100-%btb)/100	100-%btb)/100	NUM
admet-547	109	25	and	and	CCONJ
admet-547	109	26	(	(	PUNCT
admet-547	109	27	100-%ppb)/100	100-%ppb)/100	NUM
admet-547	109	28	kbb	kbb	NOUN
admet-547	110	1	[	[	X
admet-547	110	2	22	22	NUM
admet-547	110	3	]	]	X
admet-547	110	4	=	=	SYM
admet-547	110	5	fuppb	fuppb	ADJ
admet-547	110	6	/	/	SYM
admet-547	110	7	fubtb	fubtb	NOUN
admet-547	110	8	log	log	NOUN
admet-547	110	9	kpcell	kpcell	NOUN
admet-547	110	10	[	[	X
admet-547	110	11	23	23	NUM
admet-547	110	12	]	]	X
admet-547	110	13	=	=	PROPN
admet-547	110	14	1.1*log	1.1*log	PROPN
admet-547	110	15	kiam	kiam	PROPN
admet-547	110	16	1.9	1.9	NUM
admet-547	110	17	in	in	ADP
admet-547	110	18	vitro	vitro	X
admet-547	110	19	clearance	clearance	NOUN
admet-547	110	20	and	and	CCONJ
admet-547	110	21	estimated	estimate	VERB
admet-547	110	22	pk	pk	NOUN
admet-547	110	23	profile	profile	NOUN
admet-547	110	24	of	of	ADP
admet-547	110	25	gm6	gm6	PROPN
admet-547	110	26	in	in	ADP
admet-547	110	27	order	order	NOUN
admet-547	110	28	to	to	PART
admet-547	110	29	estimate	estimate	VERB
admet-547	110	30	the	the	DET
admet-547	110	31	expected	expect	VERB
admet-547	110	32	pk	pk	NOUN
admet-547	110	33	profile	profile	NOUN
admet-547	110	34	of	of	ADP
admet-547	110	35	gm6	gm6	PROPN
admet-547	110	36	in	in	ADP
admet-547	110	37	human	human	ADJ
admet-547	110	38	the	the	DET
admet-547	110	39	in	in	ADV
admet-547	110	40	vitro	vitro	X
admet-547	110	41	microsomal	microsomal	ADJ
admet-547	110	42	stability	stability	NOUN
admet-547	110	43	has	have	AUX
admet-547	110	44	been	be	AUX
admet-547	110	45	measured	measure	VERB
admet-547	110	46	.	.	PUNCT
admet-547	111	1	eurofins	eurofins	PROPN
admet-547	111	2	pharma	pharma	PROPN
admet-547	111	3	discovery	discovery	PROPN
admet-547	111	4	services	services	PROPN
admet-547	111	5	cerep	cerep	PROPN
admet-547	111	6	inc	inc	PROPN
admet-547	111	7	(	(	PUNCT
admet-547	111	8	france	france	PROPN
admet-547	111	9	)	)	PUNCT
admet-547	111	10	carried	carry	VERB
admet-547	111	11	out	out	ADP
admet-547	111	12	in	in	ADP
admet-547	111	13	vitro	vitro	X
admet-547	111	14	clearance	clearance	NOUN
admet-547	111	15	measurements	measurement	NOUN
admet-547	111	16	on	on	ADP
admet-547	111	17	gm6	gm6	PROPN
admet-547	111	18	using	use	VERB
admet-547	111	19	human	human	ADJ
admet-547	111	20	liver	liver	NOUN
admet-547	111	21	microsomes	microsome	NOUN
admet-547	111	22	.	.	PUNCT
admet-547	112	1	the	the	DET
admet-547	112	2	in	in	ADV
admet-547	112	3	vitro	vitro	X
admet-547	112	4	clearance	clearance	NOUN
admet-547	112	5	data	datum	NOUN
admet-547	112	6	so	so	ADV
admet-547	112	7	obtained	obtain	VERB
admet-547	112	8	can	can	AUX
admet-547	112	9	be	be	AUX
admet-547	112	10	used	use	VERB
admet-547	112	11	to	to	PART
admet-547	112	12	estimate	estimate	VERB
admet-547	112	13	the	the	DET
admet-547	112	14	in	in	ADP
admet-547	112	15	vivo	vivo	ADJ
admet-547	112	16	clearance	clearance	NOUN
admet-547	112	17	and	and	CCONJ
admet-547	112	18	half	half	ADJ
admet-547	112	19	-	-	PUNCT
admet-547	112	20	life	life	NOUN
admet-547	112	21	using	use	VERB
admet-547	112	22	a	a	DET
admet-547	112	23	well	well	ADV
admet-547	112	24	-	-	PUNCT
admet-547	112	25	stirred	stir	VERB
admet-547	112	26	model	model	NOUN
admet-547	112	27	[	[	X
admet-547	112	28	24	24	NUM
admet-547	112	29	]	]	PUNCT
admet-547	112	30	.	.	PUNCT
admet-547	113	1	a	a	DET
admet-547	113	2	comparative	comparative	ADJ
admet-547	113	3	study	study	NOUN
admet-547	113	4	was	be	AUX
admet-547	113	5	carried	carry	VERB
admet-547	113	6	out	out	ADP
admet-547	113	7	using	use	VERB
admet-547	113	8	gm6	gm6	PROPN
admet-547	113	9	and	and	CCONJ
admet-547	113	10	riluzole	riluzole	PROPN
admet-547	113	11	,	,	PUNCT
admet-547	113	12	an	an	DET
admet-547	113	13	fda	fda	PROPN
admet-547	113	14	approved	approve	VERB
admet-547	113	15	drug	drug	NOUN
admet-547	113	16	for	for	ADP
admet-547	113	17	als	al	NOUN
admet-547	113	18	.	.	PUNCT
admet-547	114	1	the	the	DET
admet-547	114	2	purpose	purpose	NOUN
admet-547	114	3	of	of	ADP
admet-547	114	4	the	the	DET
admet-547	114	5	study	study	NOUN
admet-547	114	6	was	be	AUX
admet-547	114	7	to	to	PART
admet-547	114	8	test	test	VERB
admet-547	114	9	whether	whether	SCONJ
admet-547	114	10	there	there	PRON
admet-547	114	11	was	be	VERB
admet-547	114	12	any	any	DET
admet-547	114	13	interaction	interaction	NOUN
admet-547	114	14	between	between	ADP
admet-547	114	15	gm6	gm6	PROPN
admet-547	114	16	and	and	CCONJ
admet-547	114	17	riluzole	riluzole	NOUN
admet-547	114	18	in	in	ADP
admet-547	114	19	the	the	DET
admet-547	114	20	intrinsic	intrinsic	ADJ
admet-547	114	21	clearance	clearance	NOUN
admet-547	114	22	assay	assay	VERB
admet-547	114	23	using	use	VERB
admet-547	114	24	human	human	ADJ
admet-547	114	25	liver	liver	NOUN
admet-547	114	26	microsomes	microsome	NOUN
admet-547	114	27	.	.	PUNCT
admet-547	115	1	a	a	DET
admet-547	115	2	pool	pool	NOUN
admet-547	115	3	of	of	ADP
admet-547	115	4	50	50	NUM
admet-547	115	5	mixed	mixed	ADJ
admet-547	115	6	gender	gender	NOUN
admet-547	115	7	human	human	ADJ
admet-547	115	8	liver	liver	NOUN
admet-547	115	9	microsomes	microsome	NOUN
admet-547	115	10	was	be	AUX
admet-547	115	11	used	use	VERB
admet-547	115	12	with	with	ADP
admet-547	115	13	a	a	DET
admet-547	115	14	final	final	ADJ
admet-547	115	15	microsomal	microsomal	ADJ
admet-547	115	16	concentration	concentration	NOUN
admet-547	115	17	0.1	0.1	NUM
admet-547	115	18	mg	mg	NUM
admet-547	115	19	/	/	SYM
admet-547	115	20	ml	ml	NOUN
admet-547	115	21	.	.	PUNCT
admet-547	116	1	the	the	DET
admet-547	116	2	test	test	NOUN
admet-547	116	3	compounds	compound	NOUN
admet-547	116	4	were	be	AUX
admet-547	116	5	dissolved	dissolve	VERB
admet-547	116	6	to	to	ADP
admet-547	116	7	a	a	DET
admet-547	116	8	0.1	0.1	NUM
admet-547	116	9	µm	µm	ADP
admet-547	116	10	concentration	concentration	NOUN
admet-547	116	11	in	in	ADP
admet-547	116	12	0.01	0.01	NUM
admet-547	116	13	%	%	NOUN
admet-547	116	14	dmso	dmso	NOUN
admet-547	116	15	,	,	PUNCT
admet-547	116	16	0.25	0.25	NUM
admet-547	116	17	%	%	NOUN
admet-547	116	18	acetonitrile	acetonitrile	NOUN
admet-547	116	19	and	and	CCONJ
admet-547	116	20	0.25	0.25	NUM
admet-547	116	21	%	%	NOUN
admet-547	116	22	methanol	methanol	NOUN
admet-547	116	23	.	.	PUNCT
admet-547	117	1	the	the	DET
admet-547	117	2	test	test	NOUN
admet-547	117	3	compounds	compound	NOUN
admet-547	117	4	were	be	AUX
admet-547	117	5	pre	pre	ADJ
admet-547	117	6	-	-	VERB
admet-547	117	7	incubated	incubate	VERB
admet-547	117	8	with	with	ADP
admet-547	117	9	the	the	DET
admet-547	117	10	pooled	pooled	ADJ
admet-547	117	11	liver	liver	NOUN
admet-547	117	12	microsomes	microsome	NOUN
admet-547	117	13	in	in	ADP
admet-547	117	14	phosphate	phosphate	ADJ
admet-547	117	15	buffer	buffer	NOUN
admet-547	117	16	and	and	CCONJ
admet-547	117	17	shaken	shake	VERB
admet-547	117	18	for	for	ADP
admet-547	117	19	5	5	NUM
admet-547	117	20	min	min	NOUN
admet-547	117	21	at	at	ADP
admet-547	117	22	37	37	NUM
admet-547	117	23	centigrade	centigrade	NOUN
admet-547	117	24	.	.	PUNCT
admet-547	118	1	the	the	DET
admet-547	118	2	reaction	reaction	NOUN
admet-547	118	3	was	be	AUX
admet-547	118	4	initiated	initiate	VERB
admet-547	118	5	by	by	ADP
admet-547	118	6	an	an	DET
admet-547	118	7	nadphgenerating	nadphgenerating	ADJ
admet-547	118	8	system	system	NOUN
admet-547	118	9	and	and	CCONJ
admet-547	118	10	incubated	incubate	VERB
admet-547	118	11	for	for	ADP
admet-547	118	12	0	0	NUM
admet-547	118	13	,	,	PUNCT
admet-547	118	14	15	15	NUM
admet-547	118	15	,	,	PUNCT
admet-547	118	16	30	30	NUM
admet-547	118	17	,	,	PUNCT
admet-547	118	18	45	45	NUM
admet-547	118	19	and	and	CCONJ
admet-547	118	20	60	60	NUM
admet-547	118	21	min	min	NOUN
admet-547	118	22	.	.	PUNCT
admet-547	119	1	the	the	DET
admet-547	119	2	reaction	reaction	NOUN
admet-547	119	3	was	be	AUX
admet-547	119	4	then	then	ADV
admet-547	119	5	stopped	stop	VERB
admet-547	119	6	by	by	ADP
admet-547	119	7	transferring	transfer	VERB
admet-547	119	8	the	the	DET
admet-547	119	9	incubation	incubation	NOUN
admet-547	119	10	mixture	mixture	NOUN
admet-547	119	11	to	to	ADP
admet-547	119	12	an	an	DET
admet-547	119	13	acetonitrile	acetonitrile	ADJ
admet-547	119	14	/	/	SYM
admet-547	119	15	methanol	methanol	NOUN
admet-547	119	16	mixture	mixture	NOUN
admet-547	119	17	.	.	PUNCT
admet-547	120	1	samples	sample	NOUN
admet-547	120	2	were	be	AUX
admet-547	120	3	then	then	ADV
admet-547	120	4	mixed	mixed	ADJ
admet-547	120	5	and	and	CCONJ
admet-547	120	6	centrifuged	centrifuge	VERB
admet-547	120	7	and	and	CCONJ
admet-547	120	8	the	the	DET
admet-547	120	9	supernatant	supernatant	NOUN
admet-547	120	10	analysed	analyse	VERB
admet-547	120	11	by	by	ADP
admet-547	120	12	hplc	hplc	PROPN
admet-547	120	13	-	-	PUNCT
admet-547	120	14	ms	ms	PROPN
admet-547	120	15	/	/	SYM
admet-547	120	16	ms	ms	PROPN
admet-547	120	17	.	.	PROPN
admet-547	121	1	the	the	DET
admet-547	121	2	compound	compound	NOUN
admet-547	121	3	remaining	remain	VERB
admet-547	121	4	after	after	ADP
admet-547	121	5	incubation	incubation	NOUN
admet-547	121	6	was	be	AUX
admet-547	121	7	admet	admet	PROPN
admet-547	121	8	&	&	CCONJ
admet-547	121	9	dmpk	dmpk	PROPN
admet-547	121	10	6(2	6(2	NUM
admet-547	121	11	)	)	PUNCT
admet-547	121	12	(	(	PUNCT
admet-547	121	13	2018	2018	NUM
admet-547	121	14	)	)	PUNCT
admet-547	121	15	176	176	NUM
admet-547	121	16	-	-	SYM
admet-547	121	17	189	189	NUM
admet-547	121	18	in	in	ADP
admet-547	121	19	vitro	vitro	X
admet-547	121	20	and	and	CCONJ
admet-547	121	21	in	in	ADP
admet-547	121	22	vivo	vivo	ADJ
admet-547	121	23	characterization	characterization	NOUN
admet-547	121	24	of	of	ADP
admet-547	121	25	gm6	gm6	PROPN
admet-547	121	26	doi	doi	NOUN
admet-547	121	27	:	:	PUNCT
admet-547	121	28	10.5599	10.5599	NUM
admet-547	121	29	/	/	SYM
admet-547	121	30	admet.547	admet.547	NOUN
admet-547	121	31	181	181	NUM
admet-547	121	32	calculated	calculate	VERB
admet-547	121	33	from	from	ADP
admet-547	121	34	the	the	DET
admet-547	121	35	peak	peak	NOUN
admet-547	121	36	area	area	NOUN
admet-547	121	37	obtained	obtain	VERB
admet-547	121	38	for	for	ADP
admet-547	121	39	each	each	DET
admet-547	121	40	sample	sample	NOUN
admet-547	121	41	time	time	NOUN
admet-547	121	42	point	point	NOUN
admet-547	121	43	relative	relative	ADJ
admet-547	121	44	to	to	ADP
admet-547	121	45	the	the	DET
admet-547	121	46	zero	zero	NUM
admet-547	121	47	-	-	PUNCT
admet-547	121	48	time	time	NOUN
admet-547	121	49	point	point	NOUN
admet-547	121	50	.	.	PUNCT
admet-547	122	1	the	the	DET
admet-547	122	2	half	half	ADJ
admet-547	122	3	-	-	PUNCT
admet-547	122	4	life	life	NOUN
admet-547	122	5	was	be	AUX
admet-547	122	6	calculated	calculate	VERB
admet-547	122	7	from	from	ADP
admet-547	122	8	the	the	DET
admet-547	122	9	slope	slope	NOUN
admet-547	122	10	of	of	ADP
admet-547	122	11	the	the	DET
admet-547	122	12	initial	initial	ADJ
admet-547	122	13	linear	linear	ADJ
admet-547	122	14	range	range	NOUN
admet-547	122	15	of	of	ADP
admet-547	122	16	the	the	DET
admet-547	122	17	logarithmic	logarithmic	ADJ
admet-547	122	18	curve	curve	NOUN
admet-547	122	19	of	of	ADP
admet-547	122	20	the	the	DET
admet-547	122	21	compound	compound	NOUN
admet-547	122	22	remaining	remain	VERB
admet-547	122	23	intact	intact	ADJ
admet-547	122	24	(	(	PUNCT
admet-547	122	25	%	%	NOUN
admet-547	122	26	)	)	PUNCT
admet-547	122	27	versus	versus	ADP
admet-547	122	28	time	time	NOUN
admet-547	122	29	,	,	PUNCT
admet-547	122	30	assuming	assume	VERB
admet-547	122	31	first	first	ADJ
admet-547	122	32	-	-	PUNCT
admet-547	122	33	order	order	NOUN
admet-547	122	34	kinetics	kinetic	NOUN
admet-547	122	35	.	.	PUNCT
admet-547	123	1	the	the	DET
admet-547	123	2	intrinsic	intrinsic	ADJ
admet-547	123	3	clearance	clearance	NOUN
admet-547	123	4	was	be	AUX
admet-547	123	5	calculated	calculate	VERB
admet-547	123	6	using	use	VERB
admet-547	123	7	equation	equation	NOUN
admet-547	123	8	(	(	PUNCT
admet-547	123	9	4	4	NUM
admet-547	123	10	)	)	PUNCT
admet-547	123	11	.	.	PUNCT
admet-547	124	1			PROPN
admet-547	124	2	int	int	PROPN
admet-547	124	3	1/2	1/2	NUM
admet-547	124	4	0.693	0.693	NUM
admet-547	124	5	μl	μl	PROPN
admet-547	124	6	/	/	SYM
admet-547	124	7	min	min	NOUN
admet-547	124	8	/	/	SYM
admet-547	124	9	mg	mg	ADJ
admet-547	124	10	protein	protein	NOUN
admet-547	124	11	protein	protein	NOUN
admet-547	124	12	conc	conc	NOUN
admet-547	124	13	.	.	PUNCT
admet-547	125	1	cl	cl	NOUN
admet-547	125	2	t	t	NOUN
admet-547	125	3			PROPN
admet-547	125	4			PROPN
admet-547	125	5	(	(	PUNCT
admet-547	125	6	4	4	NUM
admet-547	125	7	)	)	PUNCT
admet-547	125	8	quantitative	quantitative	ADJ
admet-547	125	9	immunofluorescence	immunofluorescence	NOUN
admet-547	125	10	imaging	imaging	NOUN
admet-547	125	11	phenovista	phenovista	NOUN
admet-547	125	12	biosciences	bioscience	NOUN
admet-547	125	13	llc	llc	PROPN
admet-547	125	14	(	(	PUNCT
admet-547	125	15	san	san	PROPN
admet-547	125	16	diego	diego	PROPN
admet-547	125	17	,	,	PUNCT
admet-547	125	18	ca	ca	PROPN
admet-547	125	19	,	,	PUNCT
admet-547	125	20	usa	usa	PROPN
admet-547	125	21	)	)	PUNCT
admet-547	125	22	provided	provide	VERB
admet-547	125	23	several	several	ADJ
admet-547	125	24	phenotypic	phenotypic	ADJ
admet-547	125	25	assays	assay	NOUN
admet-547	125	26	on	on	ADP
admet-547	125	27	four	four	NUM
admet-547	125	28	different	different	ADJ
admet-547	125	29	cell	cell	NOUN
admet-547	125	30	types	type	NOUN
admet-547	125	31	treated	treat	VERB
admet-547	125	32	with	with	ADP
admet-547	125	33	gm6	gm6	PROPN
admet-547	125	34	in	in	ADP
admet-547	125	35	order	order	NOUN
admet-547	125	36	to	to	PART
admet-547	125	37	reveal	reveal	VERB
admet-547	125	38	the	the	DET
admet-547	125	39	presence	presence	NOUN
admet-547	125	40	of	of	ADP
admet-547	125	41	,	,	PUNCT
admet-547	125	42	and	and	CCONJ
admet-547	125	43	reaction	reaction	NOUN
admet-547	125	44	to	to	ADP
admet-547	125	45	,	,	PUNCT
admet-547	125	46	gm6	gm6	PROPN
admet-547	125	47	in	in	ADP
admet-547	125	48	these	these	DET
admet-547	125	49	cells	cell	NOUN
admet-547	125	50	.	.	PUNCT
admet-547	126	1	the	the	DET
admet-547	126	2	primary	primary	ADJ
admet-547	126	3	goal	goal	NOUN
admet-547	126	4	of	of	ADP
admet-547	126	5	the	the	DET
admet-547	126	6	study	study	NOUN
admet-547	126	7	was	be	AUX
admet-547	126	8	to	to	PART
admet-547	126	9	identify	identify	VERB
admet-547	126	10	antibody	antibody	NOUN
admet-547	126	11	-	-	PUNCT
admet-547	126	12	based	base	VERB
admet-547	126	13	markers	marker	NOUN
admet-547	126	14	that	that	PRON
admet-547	126	15	could	could	AUX
admet-547	126	16	be	be	AUX
admet-547	126	17	used	use	VERB
admet-547	126	18	successfully	successfully	ADV
admet-547	126	19	in	in	ADP
admet-547	126	20	quantitative	quantitative	ADJ
admet-547	126	21	imaging	imaging	NOUN
admet-547	126	22	-	-	PUNCT
admet-547	126	23	based	base	VERB
admet-547	126	24	analysis	analysis	NOUN
admet-547	126	25	and	and	CCONJ
admet-547	126	26	to	to	PART
admet-547	126	27	determine	determine	VERB
admet-547	126	28	if	if	SCONJ
admet-547	126	29	the	the	DET
admet-547	126	30	application	application	NOUN
admet-547	126	31	of	of	ADP
admet-547	126	32	gm6	gm6	PROPN
admet-547	126	33	caused	cause	VERB
admet-547	126	34	quantifiable	quantifiable	ADJ
admet-547	126	35	effects	effect	NOUN
admet-547	126	36	on	on	ADP
admet-547	126	37	signalling	signal	VERB
admet-547	126	38	pathways	pathway	NOUN
admet-547	126	39	identified	identify	VERB
admet-547	126	40	by	by	ADP
admet-547	126	41	a	a	DET
admet-547	126	42	series	series	NOUN
admet-547	126	43	of	of	ADP
admet-547	126	44	antibody	antibody	NOUN
admet-547	126	45	markers	marker	NOUN
admet-547	126	46	.	.	PUNCT
admet-547	127	1	four	four	NUM
admet-547	127	2	human	human	ADJ
admet-547	127	3	cell	cell	NOUN
admet-547	127	4	types	type	NOUN
admet-547	127	5	were	be	AUX
admet-547	127	6	used	use	VERB
admet-547	127	7	:	:	PUNCT
admet-547	127	8	1	1	X
admet-547	127	9	.	.	X
admet-547	127	10	ips	ip	NOUN
admet-547	127	11	-	-	PUNCT
admet-547	127	12	derived	derive	VERB
admet-547	127	13	icell	icell	NOUN
admet-547	127	14	hepatocytes	hepatocyte	NOUN
admet-547	127	15	2.0	2.0	NUM
admet-547	127	16	(	(	PUNCT
admet-547	127	17	cdi	cdi	PROPN
admet-547	127	18	phc-100	phc-100	PROPN
admet-547	127	19	-	-	PUNCT
admet-547	127	20	020	020	NUM
admet-547	127	21	-	-	PUNCT
admet-547	127	22	001	001	NUM
admet-547	127	23	)	)	PUNCT
admet-547	127	24	(	(	PUNCT
admet-547	127	25	cultured	cultured	ADJ
admet-547	127	26	10	10	NUM
admet-547	127	27	days	day	NOUN
admet-547	127	28	in	in	ADP
admet-547	127	29	manufacturers	manufacturer	NOUN
admet-547	127	30	suggested	suggest	VERB
admet-547	127	31	media	medium	NOUN
admet-547	127	32	then	then	ADV
admet-547	127	33	treated	treat	VERB
admet-547	127	34	with	with	ADP
admet-547	127	35	gm6	gm6	PROPN
admet-547	127	36	)	)	PUNCT
admet-547	127	37	,	,	PUNCT
admet-547	127	38	2	2	X
admet-547	127	39	.	.	X
admet-547	127	40	human	human	ADJ
admet-547	127	41	brain	brain	NOUN
admet-547	127	42	microvascular	microvascular	NOUN
admet-547	127	43	endothelial	endothelial	ADJ
admet-547	127	44	cells	cell	NOUN
admet-547	127	45	[	[	X
admet-547	127	46	hbmvecs	hbmvecs	X
admet-547	127	47	]	]	PUNCT
admet-547	127	48	(	(	PUNCT
admet-547	127	49	ix	ix	PROPN
admet-547	127	50	cells	cell	NOUN
admet-547	127	51	10hu-051	10hu-051	NUM
admet-547	127	52	)	)	PUNCT
admet-547	127	53	(	(	PUNCT
admet-547	127	54	cultured	cultured	ADJ
admet-547	127	55	2	2	NUM
admet-547	127	56	days	day	NOUN
admet-547	127	57	in	in	ADP
admet-547	127	58	manufacturers	manufacturer	NOUN
admet-547	127	59	suggested	suggest	VERB
admet-547	127	60	media	medium	NOUN
admet-547	127	61	then	then	ADV
admet-547	127	62	treated	treat	VERB
admet-547	127	63	with	with	ADP
admet-547	127	64	gm6	gm6	PROPN
admet-547	127	65	)	)	PUNCT
admet-547	127	66	,	,	PUNCT
admet-547	127	67	3	3	X
admet-547	127	68	.	.	PUNCT
admet-547	127	69	ntera2	ntera2	PROPN
admet-547	127	70	differentiated	differentiated	ADJ
admet-547	127	71	cells	cell	NOUN
admet-547	127	72	(	(	PUNCT
admet-547	127	73	atcc	atcc	ADJ
admet-547	127	74	#	#	ADJ
admet-547	127	75	crl-1973	crl-1973	NOUN
admet-547	127	76	)	)	PUNCT
admet-547	127	77	(	(	PUNCT
admet-547	127	78	differentiated	differentiate	VERB
admet-547	127	79	for	for	ADP
admet-547	127	80	21	21	NUM
admet-547	127	81	days	day	NOUN
admet-547	127	82	in	in	ADP
admet-547	127	83	10	10	NUM
admet-547	127	84	µm	µm	ADP
admet-547	127	85	retinoic	retinoic	PROPN
admet-547	127	86	acid	acid	PROPN
admet-547	127	87	(	(	PUNCT
admet-547	127	88	ra	ra	PROPN
admet-547	127	89	)	)	PUNCT
admet-547	127	90	,	,	PUNCT
admet-547	127	91	0.5	0.5	NUM
admet-547	127	92	mm	mm	NOUN
admet-547	127	93	ibmx	ibmx	NOUN
admet-547	127	94	and	and	CCONJ
admet-547	127	95	1	1	NUM
admet-547	127	96	mm	mm	NUM
admet-547	127	97	8	8	NUM
admet-547	127	98	-	-	PUNCT
admet-547	127	99	br	br	NOUN
admet-547	127	100	-	-	PUNCT
admet-547	127	101	camp	camp	NOUN
admet-547	127	102	then	then	ADV
admet-547	127	103	treated	treat	VERB
admet-547	127	104	with	with	ADP
admet-547	127	105	gm6	gm6	PROPN
admet-547	127	106	)	)	PUNCT
admet-547	127	107	,	,	PUNCT
admet-547	127	108	4	4	X
admet-547	127	109	.	.	X
admet-547	127	110	ips	ip	NOUN
admet-547	127	111	-	-	PUNCT
admet-547	127	112	derived	derive	VERB
admet-547	127	113	icell	icell	NOUN
admet-547	127	114	gabaergic	gabaergic	ADJ
admet-547	127	115	neurons	neuron	NOUN
admet-547	127	116	(	(	PUNCT
admet-547	127	117	cdi	cdi	PROPN
admet-547	127	118	nrc-100	nrc-100	PROPN
admet-547	127	119	-	-	PUNCT
admet-547	127	120	010	010	NUM
admet-547	127	121	-	-	PUNCT
admet-547	127	122	001	001	NUM
admet-547	127	123	)	)	PUNCT
admet-547	127	124	(	(	PUNCT
admet-547	127	125	cultured	cultured	ADJ
admet-547	127	126	7	7	NUM
admet-547	127	127	days	day	NOUN
admet-547	127	128	in	in	ADP
admet-547	127	129	manufacturers	manufacturer	NOUN
admet-547	127	130	suggested	suggest	VERB
admet-547	127	131	media	medium	NOUN
admet-547	127	132	then	then	ADV
admet-547	127	133	treated	treat	VERB
admet-547	127	134	with	with	ADP
admet-547	127	135	gm6	gm6	PROPN
admet-547	127	136	)	)	PUNCT
admet-547	127	137	.	.	PUNCT
admet-547	128	1	all	all	DET
admet-547	128	2	cells	cell	NOUN
admet-547	128	3	were	be	AUX
admet-547	128	4	cultured	cultured	ADJ
admet-547	128	5	and	and	CCONJ
admet-547	128	6	treated	treat	VERB
admet-547	128	7	in	in	ADP
admet-547	128	8	high	high	ADJ
admet-547	128	9	density	density	NOUN
admet-547	128	10	384	384	NUM
admet-547	128	11	well	well	NOUN
admet-547	128	12	microplates	microplate	NOUN
admet-547	128	13	before	before	ADP
admet-547	128	14	fixation	fixation	NOUN
admet-547	128	15	,	,	PUNCT
admet-547	128	16	immunofluorescence	immunofluorescence	NOUN
admet-547	128	17	staining	staining	NOUN
admet-547	128	18	and	and	CCONJ
admet-547	128	19	analysis	analysis	NOUN
admet-547	128	20	using	use	VERB
admet-547	128	21	automated	automate	VERB
admet-547	128	22	quantitative	quantitative	ADJ
admet-547	128	23	microscopy	microscopy	NOUN
admet-547	128	24	.	.	PUNCT
admet-547	129	1	the	the	DET
admet-547	129	2	aim	aim	NOUN
admet-547	129	3	of	of	ADP
admet-547	129	4	the	the	DET
admet-547	129	5	analysis	analysis	NOUN
admet-547	129	6	was	be	AUX
admet-547	129	7	to	to	PART
admet-547	129	8	determine	determine	VERB
admet-547	129	9	uptake	uptake	ADJ
admet-547	129	10	and	and	CCONJ
admet-547	129	11	downstream	downstream	ADJ
admet-547	129	12	signalling	signalling	ADJ
admet-547	129	13	effects	effect	NOUN
admet-547	129	14	of	of	ADP
admet-547	129	15	gm6	gm6	PROPN
admet-547	129	16	via	via	ADP
admet-547	129	17	assessment	assessment	NOUN
admet-547	129	18	of	of	ADP
admet-547	129	19	the	the	DET
admet-547	129	20	marker	marker	NOUN
admet-547	129	21	levels	level	NOUN
admet-547	129	22	in	in	ADP
admet-547	129	23	each	each	DET
admet-547	129	24	cell	cell	NOUN
admet-547	129	25	type	type	NOUN
admet-547	129	26	under	under	ADP
admet-547	129	27	each	each	DET
admet-547	129	28	treatment	treatment	NOUN
admet-547	129	29	condition	condition	NOUN
admet-547	129	30	.	.	PUNCT
admet-547	130	1	due	due	ADP
admet-547	130	2	to	to	ADP
admet-547	130	3	the	the	DET
admet-547	130	4	unknown	unknown	ADJ
admet-547	130	5	distribution	distribution	NOUN
admet-547	130	6	and	and	CCONJ
admet-547	130	7	response	response	NOUN
admet-547	130	8	of	of	ADP
admet-547	130	9	the	the	DET
admet-547	130	10	twelve	twelve	NUM
admet-547	130	11	unique	unique	ADJ
admet-547	130	12	markers	marker	NOUN
admet-547	130	13	selected	select	VERB
admet-547	130	14	,	,	PUNCT
admet-547	130	15	a	a	DET
admet-547	130	16	general	general	ADJ
admet-547	130	17	-	-	PUNCT
admet-547	130	18	purpose	purpose	NOUN
admet-547	130	19	image	image	NOUN
admet-547	130	20	analysis	analysis	NOUN
admet-547	130	21	strategy	strategy	NOUN
admet-547	130	22	was	be	AUX
admet-547	130	23	taken	take	VERB
admet-547	130	24	whereby	whereby	SCONJ
admet-547	130	25	changes	change	NOUN
admet-547	130	26	in	in	ADP
admet-547	130	27	cellular	cellular	ADJ
admet-547	130	28	intensity	intensity	NOUN
admet-547	130	29	for	for	ADP
admet-547	130	30	each	each	DET
admet-547	130	31	marker	marker	NOUN
admet-547	130	32	would	would	AUX
admet-547	130	33	be	be	AUX
admet-547	130	34	quantified	quantify	VERB
admet-547	130	35	.	.	PUNCT
admet-547	131	1	cells	cell	NOUN
admet-547	131	2	were	be	AUX
admet-547	131	3	seeded	seed	VERB
admet-547	131	4	in	in	ADP
admet-547	131	5	384	384	NUM
admet-547	131	6	well	well	ADJ
admet-547	131	7	plates	plate	NOUN
admet-547	131	8	(	(	PUNCT
admet-547	131	9	greiner	greiner	PROPN
admet-547	131	10	)	)	PUNCT
admet-547	131	11	in	in	ADP
admet-547	131	12	culture	culture	NOUN
admet-547	131	13	media	medium	NOUN
admet-547	131	14	according	accord	VERB
admet-547	131	15	to	to	ADP
admet-547	131	16	manufacturer	manufacturer	NOUN
admet-547	131	17	’s	’s	PART
admet-547	131	18	guidelines	guideline	NOUN
admet-547	131	19	and	and	CCONJ
admet-547	131	20	where	where	SCONJ
admet-547	131	21	applicable	applicable	ADJ
admet-547	131	22	differentiated	differentiate	VERB
admet-547	131	23	before	before	ADP
admet-547	131	24	treatment	treatment	NOUN
admet-547	131	25	with	with	ADP
admet-547	131	26	gm6	gm6	PROPN
admet-547	131	27	for	for	ADP
admet-547	131	28	15	15	NUM
admet-547	131	29	minutes	minute	NOUN
admet-547	131	30	,	,	PUNCT
admet-547	131	31	2	2	NUM
admet-547	131	32	or	or	CCONJ
admet-547	131	33	4	4	NUM
admet-547	131	34	hours	hour	NOUN
admet-547	131	35	.	.	PUNCT
admet-547	132	1	treatments	treatment	NOUN
admet-547	132	2	were	be	AUX
admet-547	132	3	performed	perform	VERB
admet-547	132	4	via	via	ADP
admet-547	132	5	the	the	DET
admet-547	132	6	addition	addition	NOUN
admet-547	132	7	of	of	ADP
admet-547	132	8	a	a	DET
admet-547	132	9	10x	10x	NOUN
admet-547	132	10	solution	solution	NOUN
admet-547	132	11	as	as	ADP
admet-547	132	12	10	10	NUM
admet-547	132	13	%	%	NOUN
admet-547	132	14	of	of	ADP
admet-547	132	15	the	the	DET
admet-547	132	16	final	final	ADJ
admet-547	132	17	culture	culture	NOUN
admet-547	132	18	volume	volume	NOUN
admet-547	132	19	(	(	PUNCT
admet-547	132	20	e.g.	e.g.	ADV
admet-547	132	21	2.2	2.2	NUM
admet-547	132	22	µl	µl	NOUN
admet-547	132	23	of	of	ADP
admet-547	132	24	10	10	NUM
admet-547	132	25	mm	mm	NOUN
admet-547	132	26	gm6	gm6	PROPN
admet-547	132	27	added	add	VERB
admet-547	132	28	to	to	ADP
admet-547	132	29	20	20	NUM
admet-547	132	30	µl	µl	ADP
admet-547	132	31	culture	culture	NOUN
admet-547	132	32	volume	volume	NOUN
admet-547	132	33	for	for	ADP
admet-547	132	34	a	a	DET
admet-547	132	35	final	final	ADJ
admet-547	132	36	concentration	concentration	NOUN
admet-547	132	37	of	of	ADP
admet-547	132	38	1	1	NUM
admet-547	132	39	mm	mm	NUM
admet-547	132	40	gm6	gm6	PROPN
admet-547	132	41	)	)	PUNCT
admet-547	132	42	.	.	PUNCT
admet-547	133	1	after	after	ADP
admet-547	133	2	treatment	treatment	NOUN
admet-547	133	3	the	the	DET
admet-547	133	4	cells	cell	NOUN
admet-547	133	5	were	be	AUX
admet-547	133	6	fixed	fix	VERB
admet-547	133	7	in	in	ADP
admet-547	133	8	4	4	NUM
admet-547	133	9	%	%	NOUN
admet-547	133	10	formaldehyde	formaldehyde	NOUN
admet-547	133	11	for	for	ADP
admet-547	133	12	15	15	NUM
admet-547	133	13	minutes	minute	NOUN
admet-547	133	14	,	,	PUNCT
admet-547	133	15	washed	wash	VERB
admet-547	133	16	in	in	ADP
admet-547	133	17	pbs	pbs	NOUN
admet-547	133	18	containing	contain	VERB
admet-547	133	19	0.3	0.3	NUM
admet-547	133	20	%	%	NOUN
admet-547	133	21	triton	triton	PROPN
admet-547	133	22	x-100	x-100	PROPN
admet-547	133	23	for	for	ADP
admet-547	133	24	5	5	NUM
admet-547	133	25	minutes	minute	NOUN
admet-547	133	26	at	at	ADP
admet-547	133	27	room	room	NOUN
admet-547	133	28	temperature	temperature	NOUN
admet-547	133	29	then	then	ADV
admet-547	133	30	blocked	block	VERB
admet-547	133	31	in	in	ADP
admet-547	133	32	pbs	pbs	NOUN
admet-547	133	33	containing	contain	VERB
admet-547	133	34	either	either	CCONJ
admet-547	133	35	5	5	NUM
admet-547	133	36	%	%	NOUN
admet-547	133	37	goat	goat	NOUN
admet-547	133	38	serum	serum	NOUN
admet-547	133	39	or	or	CCONJ
admet-547	133	40	5	5	NUM
admet-547	133	41	%	%	NOUN
admet-547	133	42	donkey	donkey	NOUN
admet-547	133	43	serum	serum	NOUN
admet-547	133	44	(	(	PUNCT
admet-547	133	45	depending	depend	VERB
admet-547	133	46	on	on	ADP
admet-547	133	47	primary	primary	ADJ
admet-547	133	48	antibody	antibody	NOUN
admet-547	133	49	host	host	NOUN
admet-547	133	50	used	use	VERB
admet-547	133	51	)	)	PUNCT
admet-547	133	52	,	,	PUNCT
admet-547	133	53	1	1	NUM
admet-547	133	54	%	%	NOUN
admet-547	133	55	bsa	bsa	NOUN
admet-547	133	56	,	,	PUNCT
admet-547	133	57	and	and	CCONJ
admet-547	133	58	0.2	0.2	NUM
admet-547	133	59	%	%	NOUN
admet-547	133	60	fish	fish	NOUN
admet-547	133	61	gelatin	gelatin	NOUN
admet-547	133	62	overnight	overnight	ADV
admet-547	133	63	at	at	ADP
admet-547	133	64	4	4	NUM
admet-547	133	65	°	°	NOUN
admet-547	133	66	c	c	NOUN
admet-547	133	67	.	.	PUNCT
admet-547	134	1	primary	primary	ADJ
admet-547	134	2	antibody	antibody	NOUN
admet-547	134	3	diluted	dilute	VERB
admet-547	134	4	in	in	ADP
admet-547	134	5	blocking	block	VERB
admet-547	134	6	buffer	buffer	NOUN
admet-547	134	7	was	be	AUX
admet-547	134	8	incubated	incubate	VERB
admet-547	134	9	at	at	ADP
admet-547	134	10	4	4	NUM
admet-547	134	11	°	°	NOUN
admet-547	134	12	c	c	PROPN
admet-547	134	13	overnight	overnight	ADV
admet-547	134	14	followed	follow	VERB
admet-547	134	15	by	by	ADP
admet-547	134	16	three	three	NUM
admet-547	134	17	washes	wash	NOUN
admet-547	134	18	in	in	ADP
admet-547	134	19	pbs	pbs	PROPN
admet-547	134	20	then	then	ADV
admet-547	134	21	fluorescentlyconjugated	fluorescentlyconjugate	VERB
admet-547	134	22	secondary	secondary	ADJ
admet-547	134	23	antibodies	antibody	NOUN
admet-547	134	24	(	(	PUNCT
admet-547	134	25	1:500	1:500	NUM
admet-547	134	26	dilution	dilution	NOUN
admet-547	134	27	,	,	PUNCT
admet-547	134	28	and	and	CCONJ
admet-547	134	29	hoechst	hoechst	ADJ
admet-547	134	30	33342	33342	NUM
admet-547	134	31	(	(	PUNCT
admet-547	134	32	10	10	NUM
admet-547	134	33	µg	µg	NOUN
admet-547	134	34	/	/	SYM
admet-547	134	35	ml	ml	NOUN
admet-547	134	36	final	final	ADJ
admet-547	134	37	)	)	PUNCT
admet-547	134	38	added	add	VERB
admet-547	134	39	in	in	ADP
admet-547	134	40	pbs	pbs	PROPN
admet-547	134	41	and	and	CCONJ
admet-547	134	42	incubated	incubate	VERB
admet-547	134	43	at	at	ADP
admet-547	134	44	room	room	NOUN
admet-547	134	45	temperature	temperature	NOUN
admet-547	134	46	for	for	ADP
admet-547	134	47	1	1	NUM
admet-547	134	48	hour	hour	NOUN
admet-547	134	49	before	before	ADP
admet-547	134	50	washing	wash	VERB
admet-547	134	51	in	in	ADP
admet-547	134	52	pbs	pbs	PROPN
admet-547	134	53	three	three	NUM
admet-547	134	54	times	time	NOUN
admet-547	134	55	and	and	CCONJ
admet-547	134	56	storage	storage	NOUN
admet-547	134	57	at	at	ADP
admet-547	134	58	4	4	NUM
admet-547	134	59	°	°	NOUN
admet-547	134	60	c	c	NOUN
admet-547	134	61	.	.	PUNCT
admet-547	135	1	twelve	twelve	NUM
admet-547	135	2	unique	unique	ADJ
admet-547	135	3	markers	marker	NOUN
admet-547	135	4	were	be	AUX
admet-547	135	5	assessed	assess	VERB
admet-547	135	6	in	in	ADP
admet-547	135	7	combination	combination	NOUN
admet-547	135	8	with	with	ADP
admet-547	135	9	the	the	DET
admet-547	135	10	nuclear	nuclear	ADJ
admet-547	135	11	marker	marker	NOUN
admet-547	135	12	hoechst	hoechst	NOUN
admet-547	135	13	33342	33342	NUM
admet-547	135	14	in	in	ADP
admet-547	135	15	six	six	NUM
admet-547	135	16	staining	stain	VERB
admet-547	135	17	sets	set	NOUN
admet-547	135	18	(	(	PUNCT
admet-547	135	19	aka	aka	ADV
admet-547	135	20	palettes	palette	NOUN
admet-547	135	21	)	)	PUNCT
admet-547	135	22	;	;	PUNCT
admet-547	135	23	chicken	chicken	NOUN
admet-547	135	24	anti	anti	ADJ
admet-547	135	25	-	-	ADJ
admet-547	135	26	gm6	gm6	INTJ
admet-547	135	27	(	(	PUNCT
admet-547	135	28	genervon	genervon	PROPN
admet-547	135	29	)	)	PUNCT
admet-547	135	30	,	,	PUNCT
admet-547	135	31	rabbit	rabbit	NOUN
admet-547	135	32	anti	anti	ADJ
admet-547	135	33	-	-	ADJ
admet-547	135	34	insulin	insulin	ADJ
admet-547	135	35	receptor	receptor	NOUN
admet-547	135	36	(	(	PUNCT
admet-547	135	37	abcam	abcam	VERB
admet-547	135	38	#	#	SYM
admet-547	135	39	ab131238	ab131238	NOUN
admet-547	135	40	)	)	PUNCT
admet-547	135	41	,	,	PUNCT
admet-547	135	42	goat	goat	PROPN
admet-547	135	43	anti	anti	PROPN
admet-547	135	44	-	-	ADJ
admet-547	135	45	sod1	sod1	ADJ
admet-547	135	46	(	(	PUNCT
admet-547	135	47	abcam	abcam	VERB
admet-547	135	48	#	#	SYM
admet-547	135	49	ab62800	ab62800	NOUN
admet-547	135	50	)	)	PUNCT
admet-547	135	51	,	,	PUNCT
admet-547	135	52	mouse	mouse	NOUN
admet-547	135	53	anti	anti	ADJ
admet-547	135	54	-	-	ADJ
admet-547	135	55	insulin	insulin	ADJ
admet-547	135	56	receptor	receptor	NOUN
admet-547	135	57	beta	beta	NOUN
admet-547	135	58	(	(	PUNCT
admet-547	135	59	abcam	abcam	NOUN
admet-547	135	60	#	#	NOUN
admet-547	135	61	ab983	ab983	NOUN
admet-547	135	62	)	)	PUNCT
admet-547	135	63	,	,	PUNCT
admet-547	135	64	rabbit	rabbit	NOUN
admet-547	135	65	anti	anti	ADJ
admet-547	135	66	-	-	ADJ
admet-547	135	67	phospho	phospho	ADJ
admet-547	135	68	tau	tau	NOUN
admet-547	135	69	s356	s356	PROPN
admet-547	135	70	(	(	PUNCT
admet-547	135	71	abcam	abcam	VERB
admet-547	135	72	#	#	SYM
admet-547	135	73	ab75603	ab75603	PROPN
admet-547	135	74	)	)	PUNCT
admet-547	135	75	,	,	PUNCT
admet-547	135	76	mouse	mouse	NOUN
admet-547	135	77	anti	anti	NOUN
admet-547	135	78	-	-	NOUN
admet-547	135	79	pi3kp85	pi3kp85	ADJ
admet-547	135	80	(	(	PUNCT
admet-547	135	81	abcam	abcam	VERB
admet-547	135	82	#	#	SYM
admet-547	135	83	ab86714	ab86714	NOUN
admet-547	135	84	)	)	PUNCT
admet-547	135	85	,	,	PUNCT
admet-547	135	86	rabbit	rabbit	NOUN
admet-547	135	87	anti	anti	ADJ
admet-547	135	88	-	-	ADJ
admet-547	135	89	tdp43	tdp43	ADJ
admet-547	135	90	(	(	PUNCT
admet-547	135	91	thermoscientific	thermoscientific	NOUN
admet-547	135	92	#	#	SYM
admet-547	135	93	pa5	pa5	NOUN
admet-547	135	94	-	-	PUNCT
admet-547	135	95	29949	29949	NUM
admet-547	135	96	)	)	PUNCT
admet-547	135	97	,	,	PUNCT
admet-547	135	98	rabbit	rabbit	NOUN
admet-547	135	99	anti	anti	PROPN
admet-547	135	100	igf1	igf1	PROPN
admet-547	135	101	receptor	receptor	NOUN
admet-547	135	102	beta	beta	NOUN
admet-547	135	103	(	(	PUNCT
admet-547	135	104	cell	cell	NOUN
admet-547	135	105	signalling	signal	VERB
admet-547	135	106	#	#	SYM
admet-547	135	107	9750	9750	NUM
admet-547	135	108	)	)	PUNCT
admet-547	135	109	,	,	PUNCT
admet-547	135	110	mouse	mouse	NOUN
admet-547	135	111	anti	anti	ADJ
admet-547	135	112	-	-	ADJ
admet-547	135	113	tau	tau	ADJ
admet-547	135	114	(	(	PUNCT
admet-547	135	115	synaptic	synaptic	ADJ
admet-547	135	116	systems	system	NOUN
admet-547	135	117	klara	klara	PROPN
admet-547	135	118	valko	valko	PROPN
admet-547	135	119	et	et	PROPN
admet-547	135	120	al	al	PROPN
admet-547	135	121	.	.	PROPN
admet-547	135	122	admet	admet	PROPN
admet-547	135	123	&	&	CCONJ
admet-547	135	124	dmpk	dmpk	PROPN
admet-547	135	125	6(2	6(2	NUM
admet-547	135	126	)	)	PUNCT
admet-547	135	127	(	(	PUNCT
admet-547	135	128	2018	2018	NUM
admet-547	135	129	)	)	PUNCT
admet-547	135	130	176	176	NUM
admet-547	135	131	-	-	SYM
admet-547	135	132	189	189	NUM
admet-547	135	133	182	182	NUM
admet-547	135	134	#	#	SYM
admet-547	135	135	314011	314011	NUM
admet-547	135	136	)	)	PUNCT
admet-547	135	137	,	,	PUNCT
admet-547	135	138	rabbit	rabbit	NOUN
admet-547	135	139	anti	anti	ADJ
admet-547	135	140	-	-	ADJ
admet-547	135	141	phospho	phospho	ADJ
admet-547	135	142	tau	tau	NOUN
admet-547	135	143	t231	t231	PROPN
admet-547	135	144	(	(	PUNCT
admet-547	135	145	abcam	abcam	NOUN
admet-547	135	146	#	#	SYM
admet-547	135	147	ab151559	ab151559	PROPN
admet-547	135	148	)	)	PUNCT
admet-547	135	149	,	,	PUNCT
admet-547	135	150	mouse	mouse	NOUN
admet-547	135	151	anti	anti	ADJ
admet-547	135	152	-	-	ADJ
admet-547	135	153	igf1	igf1	ADJ
admet-547	135	154	receptor	receptor	NOUN
admet-547	135	155	(	(	PUNCT
admet-547	135	156	abcam	abcam	VERB
admet-547	135	157	ab16890	ab16890	ADJ
admet-547	135	158	)	)	PUNCT
admet-547	135	159	and	and	CCONJ
admet-547	135	160	rabbit	rabbit	NOUN
admet-547	135	161	anti	anti	ADJ
admet-547	135	162	-	-	ADJ
admet-547	135	163	phospho	phospho	ADJ
admet-547	135	164	insulin	insulin	NOUN
admet-547	135	165	recptor	recptor	NOUN
admet-547	135	166	beta	beta	NOUN
admet-547	135	167	y972	y972	PROPN
admet-547	135	168	(	(	PUNCT
admet-547	135	169	abcam	abcam	PROPN
admet-547	135	170	5678	5678	NUM
admet-547	135	171	)	)	PUNCT
admet-547	135	172	.	.	PUNCT
admet-547	136	1	imaging	imaging	NOUN
admet-547	136	2	was	be	AUX
admet-547	136	3	performed	perform	VERB
admet-547	136	4	using	use	VERB
admet-547	136	5	a	a	DET
admet-547	136	6	thermoscientific	thermoscientific	NOUN
admet-547	136	7	cx7	cx7	NOUN
admet-547	136	8	automated	automate	VERB
admet-547	136	9	fluorescence	fluorescence	NOUN
admet-547	136	10	microscope	microscope	NOUN
admet-547	136	11	.	.	PUNCT
admet-547	137	1	images	image	NOUN
admet-547	137	2	were	be	AUX
admet-547	137	3	collected	collect	VERB
admet-547	137	4	using	use	VERB
admet-547	137	5	filter	filter	NOUN
admet-547	137	6	sets	set	NOUN
admet-547	137	7	appropriate	appropriate	ADJ
admet-547	137	8	for	for	ADP
admet-547	137	9	the	the	DET
admet-547	137	10	fluorescently	fluorescently	ADV
admet-547	137	11	-	-	PUNCT
admet-547	137	12	conjugated	conjugate	VERB
admet-547	137	13	secondary	secondary	ADJ
admet-547	137	14	antibodies	antibody	NOUN
admet-547	137	15	and	and	CCONJ
admet-547	137	16	images	image	NOUN
admet-547	137	17	analysed	analyse	VERB
admet-547	137	18	using	use	VERB
admet-547	137	19	the	the	DET
admet-547	137	20	compartmental	compartmental	ADJ
admet-547	137	21	analysis	analysis	NOUN
admet-547	137	22	(	(	PUNCT
admet-547	137	23	thermoscientific	thermoscientific	NOUN
admet-547	137	24	)	)	PUNCT
admet-547	137	25	algorithm	algorithm	NOUN
admet-547	137	26	as	as	ADP
admet-547	137	27	part	part	NOUN
admet-547	137	28	of	of	ADP
admet-547	137	29	the	the	DET
admet-547	137	30	hcs	hcs	PROPN
admet-547	137	31	studio	studio	PROPN
admet-547	137	32	software	software	NOUN
admet-547	137	33	package	package	NOUN
admet-547	137	34	.	.	PUNCT
admet-547	138	1	data	datum	NOUN
admet-547	138	2	were	be	AUX
admet-547	138	3	processed	process	VERB
admet-547	138	4	using	use	VERB
admet-547	138	5	microsoft	microsoft	PROPN
admet-547	138	6	excel	excel	VERB
admet-547	138	7	to	to	PART
admet-547	138	8	calculate	calculate	NOUN
admet-547	138	9	mean	mean	VERB
admet-547	138	10	,	,	PUNCT
admet-547	138	11	standard	standard	ADJ
admet-547	138	12	deviation	deviation	NOUN
admet-547	138	13	and	and	CCONJ
admet-547	138	14	strictly	strictly	ADV
admet-547	138	15	standardized	standardized	ADJ
admet-547	138	16	mean	mean	ADJ
admet-547	138	17	difference	difference	NOUN
admet-547	138	18	(	(	PUNCT
admet-547	138	19	ssmd	ssmd	NOUN
admet-547	138	20	)	)	PUNCT
admet-547	138	21	scores	score	NOUN
admet-547	138	22	to	to	PART
admet-547	138	23	assess	assess	VERB
admet-547	138	24	statistical	statistical	ADJ
admet-547	138	25	significance	significance	NOUN
admet-547	138	26	versus	versus	ADP
admet-547	138	27	control	control	NOUN
admet-547	138	28	treatments	treatment	NOUN
admet-547	138	29	.	.	PUNCT
admet-547	139	1	in	in	ADP
admet-547	139	2	vivo	vivo	ADJ
admet-547	139	3	brain	brain	NOUN
admet-547	139	4	penetration	penetration	NOUN
admet-547	139	5	studies	study	NOUN
admet-547	139	6	c57bl6	c57bl6	NOUN
admet-547	139	7	mice	mouse	NOUN
admet-547	139	8	were	be	AUX
admet-547	139	9	injected	inject	VERB
admet-547	139	10	with	with	ADP
admet-547	139	11	a	a	DET
admet-547	139	12	single	single	ADJ
admet-547	139	13	bolus	bolus	NOUN
admet-547	139	14	iv	iv	NUM
admet-547	139	15	tail	tail	NOUN
admet-547	139	16	vein	vein	VERB
admet-547	139	17	injection	injection	NOUN
admet-547	139	18	of	of	ADP
admet-547	139	19	gm6	gm6	PROPN
admet-547	139	20	at	at	ADP
admet-547	139	21	0.2	0.2	NUM
admet-547	139	22	and	and	CCONJ
admet-547	139	23	2.0	2.0	NUM
admet-547	139	24	mg	mg	PROPN
admet-547	139	25	/	/	SYM
admet-547	139	26	kg	kg	PROPN
admet-547	139	27	.	.	PUNCT
admet-547	140	1	at	at	ADP
admet-547	140	2	four	four	NUM
admet-547	140	3	hours	hour	NOUN
admet-547	140	4	,	,	PUNCT
admet-547	140	5	the	the	DET
admet-547	140	6	animals	animal	NOUN
admet-547	140	7	were	be	AUX
admet-547	140	8	sacrificed	sacrifice	VERB
admet-547	140	9	,	,	PUNCT
admet-547	140	10	and	and	CCONJ
admet-547	140	11	half	half	NOUN
admet-547	140	12	of	of	ADP
admet-547	140	13	the	the	DET
admet-547	140	14	brain	brain	NOUN
admet-547	140	15	was	be	AUX
admet-547	140	16	frozen	freeze	VERB
admet-547	140	17	for	for	ADP
admet-547	140	18	elisa	elisa	NOUN
admet-547	140	19	analysis	analysis	NOUN
admet-547	140	20	.	.	PUNCT
admet-547	141	1	the	the	DET
admet-547	141	2	detailed	detailed	ADJ
admet-547	141	3	experimental	experimental	ADJ
admet-547	141	4	process	process	NOUN
admet-547	141	5	has	have	AUX
admet-547	141	6	been	be	AUX
admet-547	141	7	published	publish	VERB
admet-547	141	8	previously	previously	ADV
admet-547	141	9	[	[	X
admet-547	141	10	25	25	NUM
admet-547	141	11	]	]	PUNCT
admet-547	141	12	.	.	PUNCT
admet-547	142	1	results	result	NOUN
admet-547	142	2	and	and	CCONJ
admet-547	142	3	discussion	discussion	NOUN
admet-547	142	4	physicochemical	physicochemical	ADJ
admet-547	142	5	and	and	CCONJ
admet-547	142	6	biomimetic	biomimetic	ADJ
admet-547	142	7	properties	property	NOUN
admet-547	142	8	of	of	ADP
admet-547	142	9	gm6	gm6	PROPN
admet-547	142	10	it	it	PRON
admet-547	142	11	is	be	AUX
admet-547	142	12	important	important	ADJ
admet-547	142	13	to	to	PART
admet-547	142	14	determine	determine	VERB
admet-547	142	15	how	how	SCONJ
admet-547	142	16	gm6	gm6	PROPN
admet-547	142	17	behaves	behave	VERB
admet-547	142	18	in	in	ADP
admet-547	142	19	vivo	vivo	NOUN
admet-547	142	20	and	and	CCONJ
admet-547	142	21	what	what	PRON
admet-547	142	22	are	be	AUX
admet-547	142	23	its	its	PRON
admet-547	142	24	physicochemical	physicochemical	ADJ
admet-547	142	25	and	and	CCONJ
admet-547	142	26	drug	drug	NOUN
admet-547	142	27	-	-	PUNCT
admet-547	142	28	like	like	ADJ
admet-547	142	29	properties	property	NOUN
admet-547	142	30	and	and	CCONJ
admet-547	142	31	can	can	AUX
admet-547	142	32	it	it	PRON
admet-547	142	33	’s	’	VERB
admet-547	142	34	in	in	ADP
admet-547	142	35	vivo	vivo	ADJ
admet-547	142	36	distribution	distribution	NOUN
admet-547	142	37	and	and	CCONJ
admet-547	142	38	pharmacokinetic	pharmacokinetic	ADJ
admet-547	142	39	behaviour	behaviour	NOUN
admet-547	142	40	be	be	AUX
admet-547	142	41	predicted	predict	VERB
admet-547	142	42	.	.	PUNCT
admet-547	143	1	similar	similar	ADJ
admet-547	143	2	to	to	ADP
admet-547	143	3	other	other	ADJ
admet-547	143	4	peptide	peptide	ADJ
admet-547	143	5	therapeutics	therapeutic	NOUN
admet-547	143	6	it	it	PRON
admet-547	143	7	was	be	AUX
admet-547	143	8	expected	expect	VERB
admet-547	143	9	that	that	SCONJ
admet-547	143	10	gm6	gm6	PRON
admet-547	143	11	would	would	AUX
admet-547	143	12	not	not	PART
admet-547	143	13	be	be	AUX
admet-547	143	14	stable	stable	ADJ
admet-547	143	15	in	in	ADP
admet-547	143	16	plasma	plasma	NOUN
admet-547	143	17	,	,	PUNCT
admet-547	143	18	so	so	ADV
admet-547	143	19	measurement	measurement	NOUN
admet-547	143	20	of	of	ADP
admet-547	143	21	the	the	DET
admet-547	143	22	traditionally	traditionally	ADV
admet-547	143	23	used	use	VERB
admet-547	143	24	plasma	plasma	NOUN
admet-547	143	25	vs.	vs.	ADP
admet-547	143	26	time	time	NOUN
admet-547	143	27	pk	pk	NOUN
admet-547	143	28	profile	profile	NOUN
admet-547	143	29	would	would	AUX
admet-547	143	30	not	not	PART
admet-547	143	31	be	be	AUX
admet-547	143	32	feasible	feasible	ADJ
admet-547	143	33	.	.	PUNCT
admet-547	144	1	therefore	therefore	ADV
admet-547	144	2	,	,	PUNCT
admet-547	144	3	the	the	DET
admet-547	144	4	protein	protein	NOUN
admet-547	144	5	and	and	CCONJ
admet-547	144	6	phospholipid	phospholipid	NOUN
admet-547	144	7	binding	binding	NOUN
admet-547	144	8	of	of	ADP
admet-547	144	9	gm6	gm6	PROPN
admet-547	144	10	was	be	AUX
admet-547	144	11	assessed	assess	VERB
admet-547	144	12	using	use	VERB
admet-547	144	13	biomimetic	biomimetic	ADJ
admet-547	144	14	hplc	hplc	NOUN
admet-547	144	15	experiments	experiment	NOUN
admet-547	144	16	.	.	PUNCT
admet-547	145	1	the	the	DET
admet-547	145	2	results	result	NOUN
admet-547	145	3	of	of	ADP
admet-547	145	4	the	the	DET
admet-547	145	5	measurements	measurement	NOUN
admet-547	145	6	of	of	ADP
admet-547	145	7	protein	protein	NOUN
admet-547	145	8	and	and	CCONJ
admet-547	145	9	phospholipid	phospholipid	NOUN
admet-547	145	10	binding	binding	NOUN
admet-547	145	11	of	of	ADP
admet-547	145	12	gm6	gm6	PROPN
admet-547	145	13	are	be	AUX
admet-547	145	14	listed	list	VERB
admet-547	145	15	in	in	ADP
admet-547	145	16	table	table	NOUN
admet-547	145	17	2	2	NUM
admet-547	145	18	,	,	PUNCT
admet-547	145	19	including	include	VERB
admet-547	145	20	the	the	DET
admet-547	145	21	estimated	estimate	VERB
admet-547	145	22	in	in	ADP
admet-547	145	23	vivo	vivo	ADJ
admet-547	145	24	distribution	distribution	NOUN
admet-547	145	25	properties	property	NOUN
admet-547	145	26	of	of	ADP
admet-547	145	27	gm6	gm6	PROPN
admet-547	145	28	using	use	VERB
admet-547	145	29	the	the	DET
admet-547	145	30	model	model	NOUN
admet-547	145	31	equations	equation	NOUN
admet-547	145	32	listed	list	VERB
admet-547	145	33	in	in	ADP
admet-547	145	34	table	table	NOUN
admet-547	145	35	1	1	NUM
admet-547	145	36	.	.	PUNCT
admet-547	146	1	it	it	PRON
admet-547	146	2	can	can	AUX
admet-547	146	3	be	be	AUX
admet-547	146	4	seen	see	VERB
admet-547	146	5	that	that	SCONJ
admet-547	146	6	due	due	ADP
admet-547	146	7	to	to	ADP
admet-547	146	8	the	the	DET
admet-547	146	9	two	two	NUM
admet-547	146	10	arginine	arginine	NOUN
admet-547	146	11	amino	amino	NOUN
admet-547	146	12	acids	acid	NOUN
admet-547	146	13	in	in	ADP
admet-547	146	14	the	the	DET
admet-547	146	15	sequence	sequence	NOUN
admet-547	146	16	gm6	gm6	PROPN
admet-547	146	17	is	be	AUX
admet-547	146	18	positively	positively	ADV
admet-547	146	19	charged	charge	VERB
admet-547	146	20	at	at	ADP
admet-547	146	21	physiological	physiological	ADJ
admet-547	146	22	ph	ph	NOUN
admet-547	146	23	.	.	PUNCT
admet-547	147	1	therefore	therefore	ADV
admet-547	147	2	,	,	PUNCT
admet-547	147	3	it	it	PRON
admet-547	147	4	's	be	AUX
admet-547	147	5	binding	bind	VERB
admet-547	147	6	to	to	ADP
admet-547	147	7	alpha-1	alpha-1	NOUN
admet-547	147	8	-	-	PUNCT
admet-547	147	9	acid	acid	NOUN
admet-547	147	10	glycoprotein	glycoprotein	NOUN
admet-547	147	11	(	(	PUNCT
admet-547	147	12	agp	agp	NOUN
admet-547	147	13	)	)	PUNCT
admet-547	147	14	and	and	CCONJ
admet-547	147	15	immobilized	immobilize	VERB
admet-547	147	16	artificial	artificial	ADJ
admet-547	147	17	membrane	membrane	NOUN
admet-547	147	18	(	(	PUNCT
admet-547	147	19	iam	iam	PROPN
admet-547	147	20	)	)	PUNCT
admet-547	147	21	is	be	AUX
admet-547	147	22	very	very	ADV
admet-547	147	23	strong	strong	ADJ
admet-547	147	24	.	.	PUNCT
admet-547	148	1	the	the	DET
admet-547	148	2	total	total	ADJ
admet-547	148	3	plasma	plasma	NOUN
admet-547	148	4	protein	protein	NOUN
admet-547	148	5	binding	bind	VERB
admet-547	148	6	is	be	AUX
admet-547	148	7	expected	expect	VERB
admet-547	148	8	to	to	PART
admet-547	148	9	be	be	AUX
admet-547	148	10	31	31	NUM
admet-547	148	11	%	%	NOUN
admet-547	148	12	.	.	PUNCT
admet-547	149	1	however	however	ADV
admet-547	149	2	,	,	PUNCT
admet-547	149	3	due	due	ADP
admet-547	149	4	to	to	ADP
admet-547	149	5	the	the	DET
admet-547	149	6	strong	strong	ADJ
admet-547	149	7	iam	iam	PROPN
admet-547	149	8	binding	bind	VERB
admet-547	149	9	,	,	PUNCT
admet-547	149	10	it	it	PRON
admet-547	149	11	is	be	AUX
admet-547	149	12	very	very	ADV
admet-547	149	13	likely	likely	ADJ
admet-547	149	14	that	that	SCONJ
admet-547	149	15	gm6	gm6	PRON
admet-547	149	16	also	also	ADV
admet-547	149	17	partitions	partition	VERB
admet-547	149	18	quickly	quickly	ADV
admet-547	149	19	into	into	ADP
admet-547	149	20	the	the	DET
admet-547	149	21	blood	blood	NOUN
admet-547	149	22	cells	cell	NOUN
admet-547	149	23	.	.	PUNCT
admet-547	150	1	the	the	DET
admet-547	150	2	volume	volume	NOUN
admet-547	150	3	of	of	ADP
admet-547	150	4	distribution	distribution	NOUN
admet-547	150	5	was	be	AUX
admet-547	150	6	estimated	estimate	VERB
admet-547	150	7	from	from	ADP
admet-547	150	8	the	the	DET
admet-547	150	9	difference	difference	NOUN
admet-547	150	10	of	of	ADP
admet-547	150	11	binding	binding	NOUN
admet-547	150	12	of	of	ADP
admet-547	150	13	gm6	gm6	PROPN
admet-547	150	14	to	to	ADP
admet-547	150	15	albumin	albumin	NOUN
admet-547	150	16	and	and	CCONJ
admet-547	150	17	iam	iam	PROPN
admet-547	150	18	according	accord	VERB
admet-547	150	19	to	to	ADP
admet-547	150	20	the	the	DET
admet-547	150	21	model	model	NOUN
admet-547	150	22	published	publish	VERB
admet-547	150	23	for	for	ADP
admet-547	150	24	marketed	market	VERB
admet-547	150	25	drugs	drug	NOUN
admet-547	150	26	[	[	X
admet-547	150	27	17	17	NUM
admet-547	150	28	]	]	PUNCT
admet-547	150	29	that	that	PRON
admet-547	150	30	was	be	AUX
admet-547	150	31	7.8	7.8	NUM
admet-547	150	32	l	l	NOUN
admet-547	150	33	/	/	SYM
admet-547	150	34	kg	kg	NOUN
admet-547	150	35	using	use	VERB
admet-547	150	36	the	the	DET
admet-547	150	37	equation	equation	NOUN
admet-547	150	38	listed	list	VERB
admet-547	150	39	in	in	ADP
admet-547	150	40	table	table	NOUN
admet-547	150	41	1	1	NUM
admet-547	150	42	.	.	PUNCT
admet-547	151	1	the	the	DET
admet-547	151	2	brain	brain	NOUN
admet-547	151	3	tissue	tissue	NOUN
admet-547	151	4	binding	bind	VERB
admet-547	151	5	of	of	ADP
admet-547	151	6	gm6	gm6	PROPN
admet-547	151	7	is	be	AUX
admet-547	151	8	estimated	estimate	VERB
admet-547	151	9	to	to	PART
admet-547	151	10	be	be	AUX
admet-547	151	11	58.3	58.3	NUM
admet-547	151	12	%	%	NOUN
admet-547	151	13	which	which	PRON
admet-547	151	14	is	be	AUX
admet-547	151	15	higher	high	ADJ
admet-547	151	16	than	than	ADP
admet-547	151	17	the	the	DET
admet-547	151	18	plasma	plasma	NOUN
admet-547	151	19	protein	protein	NOUN
admet-547	151	20	binding	bind	VERB
admet-547	151	21	suggesting	suggest	VERB
admet-547	151	22	higher	high	ADJ
admet-547	151	23	total	total	ADJ
admet-547	151	24	brain	brain	NOUN
admet-547	151	25	concentration	concentration	NOUN
admet-547	151	26	than	than	ADP
admet-547	151	27	total	total	ADJ
admet-547	151	28	plasma	plasma	NOUN
admet-547	151	29	concentration	concentration	NOUN
admet-547	151	30	.	.	PUNCT
admet-547	152	1	the	the	DET
admet-547	152	2	brain	brain	NOUN
admet-547	152	3	to	to	AUX
admet-547	152	4	plasma	plasma	VERB
admet-547	152	5	total	total	ADJ
admet-547	152	6	concentration	concentration	NOUN
admet-547	152	7	ratio	ratio	NOUN
admet-547	152	8	is	be	AUX
admet-547	152	9	expected	expect	VERB
admet-547	152	10	to	to	PART
admet-547	152	11	be	be	AUX
admet-547	152	12	1.65	1.65	NUM
admet-547	152	13	.	.	PUNCT
admet-547	153	1	due	due	ADP
admet-547	153	2	to	to	ADP
admet-547	153	3	the	the	DET
admet-547	153	4	strong	strong	ADJ
admet-547	153	5	iam	iam	PROPN
admet-547	153	6	binding	bind	VERB
admet-547	153	7	,	,	PUNCT
admet-547	153	8	the	the	DET
admet-547	153	9	estimated	estimate	VERB
admet-547	153	10	intracellular	intracellular	ADJ
admet-547	153	11	concentration	concentration	NOUN
admet-547	153	12	is	be	AUX
admet-547	153	13	approximately	approximately	ADV
admet-547	153	14	5	5	NUM
admet-547	153	15	times	time	NOUN
admet-547	153	16	higher	high	ADJ
admet-547	153	17	than	than	ADP
admet-547	153	18	the	the	DET
admet-547	153	19	extracellular	extracellular	ADJ
admet-547	153	20	concentration	concentration	NOUN
admet-547	153	21	using	use	VERB
admet-547	153	22	the	the	DET
admet-547	153	23	models	model	NOUN
admet-547	153	24	obtained	obtain	VERB
admet-547	153	25	with	with	ADP
admet-547	153	26	hela	hela	PROPN
admet-547	153	27	cell	cell	NOUN
admet-547	154	1	[	[	X
admet-547	154	2	23	23	NUM
admet-547	154	3	]	]	PUNCT
admet-547	154	4	.	.	PUNCT
admet-547	155	1	the	the	DET
admet-547	155	2	drug	drug	NOUN
admet-547	155	3	efficiency	efficiency	NOUN
admet-547	155	4	which	which	PRON
admet-547	155	5	is	be	AUX
admet-547	155	6	defined	define	VERB
admet-547	155	7	as	as	ADP
admet-547	155	8	the	the	DET
admet-547	155	9	free	free	ADJ
admet-547	155	10	bio	bio	NOUN
admet-547	155	11	-	-	ADJ
admet-547	155	12	phase	phase	NOUN
admet-547	155	13	concentration	concentration	NOUN
admet-547	155	14	relative	relative	ADJ
admet-547	155	15	to	to	ADP
admet-547	155	16	the	the	DET
admet-547	155	17	dose	dose	NOUN
admet-547	155	18	[	[	X
admet-547	155	19	26	26	NUM
admet-547	155	20	]	]	PUNCT
admet-547	155	21	is	be	AUX
admet-547	155	22	over	over	ADP
admet-547	155	23	8	8	NUM
admet-547	155	24	%	%	NOUN
admet-547	155	25	which	which	PRON
admet-547	155	26	is	be	AUX
admet-547	155	27	much	much	ADV
admet-547	155	28	above	above	ADP
admet-547	155	29	the	the	DET
admet-547	155	30	expected	expect	VERB
admet-547	155	31	1	1	NUM
admet-547	155	32	%	%	NOUN
admet-547	155	33	that	that	PRON
admet-547	155	34	is	be	AUX
admet-547	155	35	characteristic	characteristic	ADJ
admet-547	155	36	of	of	ADP
admet-547	155	37	the	the	DET
admet-547	155	38	marketed	market	VERB
admet-547	155	39	drugs	drug	NOUN
admet-547	155	40	.	.	PUNCT
admet-547	156	1	from	from	ADP
admet-547	156	2	the	the	DET
admet-547	156	3	biomimetic	biomimetic	ADJ
admet-547	156	4	models	model	NOUN
admet-547	156	5	only	only	ADV
admet-547	156	6	,	,	PUNCT
admet-547	156	7	the	the	DET
admet-547	156	8	total	total	ADJ
admet-547	156	9	brain	brain	NOUN
admet-547	156	10	to	to	ADP
admet-547	156	11	plasma	plasma	NOUN
admet-547	156	12	concentration	concentration	NOUN
admet-547	156	13	ratio	ratio	NOUN
admet-547	156	14	can	can	AUX
admet-547	156	15	be	be	AUX
admet-547	156	16	estimated	estimate	VERB
admet-547	156	17	based	base	VERB
admet-547	156	18	on	on	ADP
admet-547	156	19	the	the	DET
admet-547	156	20	difference	difference	NOUN
admet-547	156	21	between	between	ADP
admet-547	156	22	the	the	DET
admet-547	156	23	brain	brain	NOUN
admet-547	156	24	tissue	tissue	NOUN
admet-547	156	25	and	and	CCONJ
admet-547	156	26	the	the	DET
admet-547	156	27	plasma	plasma	NOUN
admet-547	156	28	protein	protein	NOUN
admet-547	156	29	binding	bind	VERB
admet-547	156	30	as	as	SCONJ
admet-547	156	31	shown	show	VERB
admet-547	156	32	in	in	ADP
admet-547	156	33	table	table	NOUN
admet-547	156	34	1	1	NUM
admet-547	156	35	.	.	PUNCT
admet-547	157	1	figures	figure	NOUN
admet-547	157	2	1	1	NUM
admet-547	157	3	and	and	CCONJ
admet-547	157	4	2	2	NUM
admet-547	157	5	show	show	NOUN
admet-547	157	6	that	that	SCONJ
admet-547	157	7	gm6	gm6	PROPN
admet-547	157	8	has	have	VERB
admet-547	157	9	good	good	ADJ
admet-547	157	10	drug	drug	NOUN
admet-547	157	11	-	-	PUNCT
admet-547	157	12	like	like	ADJ
admet-547	157	13	properties	property	NOUN
admet-547	157	14	similar	similar	ADJ
admet-547	157	15	to	to	ADP
admet-547	157	16	marketed	market	VERB
admet-547	157	17	small	small	ADJ
admet-547	157	18	molecule	molecule	NOUN
admet-547	157	19	drugs	drug	NOUN
admet-547	157	20	.	.	PUNCT
admet-547	158	1	gm6	gm6	PROPN
admet-547	158	2	is	be	AUX
admet-547	158	3	well	well	ADV
admet-547	158	4	positioned	position	VERB
admet-547	158	5	in	in	ADP
admet-547	158	6	the	the	DET
admet-547	158	7	middle	middle	NOUN
admet-547	158	8	of	of	ADP
admet-547	158	9	the	the	DET
admet-547	158	10	marketed	market	VERB
admet-547	158	11	drugs	drug	NOUN
admet-547	158	12	based	base	VERB
admet-547	158	13	on	on	ADP
admet-547	158	14	the	the	DET
admet-547	158	15	plot	plot	NOUN
admet-547	158	16	of	of	ADP
admet-547	158	17	the	the	DET
admet-547	158	18	estimated	estimate	VERB
admet-547	158	19	brain	brain	NOUN
admet-547	158	20	to	to	ADP
admet-547	158	21	blood	blood	NOUN
admet-547	158	22	ratio	ratio	NOUN
admet-547	158	23	(	(	PUNCT
admet-547	158	24	log	log	PROPN
admet-547	158	25	kbb	kbb	PROPN
admet-547	158	26	)	)	PUNCT
admet-547	158	27	and	and	CCONJ
admet-547	158	28	steady	steady	ADJ
admet-547	158	29	-	-	PUNCT
admet-547	158	30	state	state	NOUN
admet-547	158	31	volume	volume	NOUN
admet-547	158	32	of	of	ADP
admet-547	158	33	distribution	distribution	NOUN
admet-547	158	34	(	(	PUNCT
admet-547	158	35	log	log	VERB
admet-547	158	36	vdss	vdss	ADV
admet-547	158	37	)	)	PUNCT
admet-547	158	38	.	.	PUNCT
admet-547	159	1	it	it	PRON
admet-547	159	2	was	be	AUX
admet-547	159	3	found	find	VERB
admet-547	159	4	that	that	SCONJ
admet-547	159	5	70	70	NUM
admet-547	159	6	%	%	NOUN
admet-547	159	7	of	of	ADP
admet-547	159	8	gm6	gm6	PROPN
admet-547	159	9	was	be	AUX
admet-547	159	10	stable	stable	ADJ
admet-547	159	11	in	in	ADP
admet-547	159	12	human	human	ADJ
admet-547	159	13	liver	liver	NOUN
admet-547	159	14	microsomes	microsome	NOUN
admet-547	159	15	after	after	ADP
admet-547	159	16	60	60	NUM
admet-547	159	17	min	min	NOUN
admet-547	159	18	.	.	PUNCT
admet-547	160	1	the	the	DET
admet-547	160	2	addition	addition	NOUN
admet-547	160	3	of	of	ADP
admet-547	160	4	admet	admet	PROPN
admet-547	160	5	&	&	CCONJ
admet-547	160	6	dmpk	dmpk	PROPN
admet-547	160	7	6(2	6(2	NUM
admet-547	160	8	)	)	PUNCT
admet-547	160	9	(	(	PUNCT
admet-547	160	10	2018	2018	NUM
admet-547	160	11	)	)	PUNCT
admet-547	160	12	176	176	NUM
admet-547	160	13	-	-	SYM
admet-547	160	14	189	189	NUM
admet-547	160	15	in	in	ADP
admet-547	160	16	vitro	vitro	X
admet-547	160	17	and	and	CCONJ
admet-547	160	18	in	in	ADP
admet-547	160	19	vivo	vivo	ADJ
admet-547	160	20	characterization	characterization	NOUN
admet-547	160	21	of	of	ADP
admet-547	160	22	gm6	gm6	PROPN
admet-547	160	23	doi	doi	NOUN
admet-547	160	24	:	:	PUNCT
admet-547	160	25	10.5599	10.5599	NUM
admet-547	160	26	/	/	SYM
admet-547	160	27	admet.547	admet.547	ADJ
admet-547	160	28	183	183	NUM
admet-547	160	29	riluzole	riluzole	NOUN
admet-547	160	30	to	to	ADP
admet-547	160	31	the	the	DET
admet-547	160	32	liver	liver	NOUN
admet-547	160	33	microsomes	microsome	NOUN
admet-547	160	34	did	do	AUX
admet-547	160	35	not	not	PART
admet-547	160	36	change	change	VERB
admet-547	160	37	the	the	DET
admet-547	160	38	clearance	clearance	NOUN
admet-547	160	39	of	of	ADP
admet-547	160	40	gm6	gm6	PROPN
admet-547	160	41	nor	nor	CCONJ
admet-547	160	42	the	the	DET
admet-547	160	43	riluzole	riluzole	NOUN
admet-547	160	44	clearance	clearance	NOUN
admet-547	160	45	,	,	PUNCT
admet-547	160	46	suggesting	suggest	VERB
admet-547	160	47	no	no	DET
admet-547	160	48	drug	drug	NOUN
admet-547	160	49	-	-	PUNCT
admet-547	160	50	drug	drug	NOUN
admet-547	160	51	interactions	interaction	NOUN
admet-547	160	52	.	.	PUNCT
admet-547	161	1	further	further	ADJ
admet-547	161	2	studies	study	NOUN
admet-547	161	3	will	will	AUX
admet-547	161	4	be	be	AUX
admet-547	161	5	needed	need	VERB
admet-547	161	6	to	to	PART
admet-547	161	7	estimate	estimate	VERB
admet-547	161	8	the	the	DET
admet-547	161	9	renal	renal	ADJ
admet-547	161	10	clearance	clearance	NOUN
admet-547	161	11	of	of	ADP
admet-547	161	12	peptides	peptide	NOUN
admet-547	161	13	which	which	PRON
admet-547	161	14	is	be	AUX
admet-547	161	15	a	a	DET
admet-547	161	16	more	more	ADV
admet-547	161	17	typical	typical	ADJ
admet-547	161	18	route	route	NOUN
admet-547	161	19	of	of	ADP
admet-547	161	20	elimination	elimination	NOUN
admet-547	161	21	[	[	X
admet-547	161	22	27	27	NUM
admet-547	161	23	]	]	PUNCT
admet-547	161	24	.	.	PUNCT
admet-547	162	1	table	table	NOUN
admet-547	162	2	2	2	NUM
admet-547	162	3	.	.	PUNCT
admet-547	163	1	the	the	DET
admet-547	163	2	measured	measure	VERB
admet-547	163	3	biomimetic	biomimetic	ADJ
admet-547	163	4	properties	property	NOUN
admet-547	163	5	of	of	ADP
admet-547	163	6	gm6	gm6	PROPN
admet-547	163	7	using	use	VERB
admet-547	163	8	published	publish	VERB
admet-547	163	9	models	model	NOUN
admet-547	163	10	for	for	ADP
admet-547	163	11	small	small	ADJ
admet-547	163	12	molecule	molecule	NOUN
admet-547	163	13	marketed	market	VERB
admet-547	163	14	drugs	drug	NOUN
admet-547	163	15	[	[	X
admet-547	163	16	22	22	NUM
admet-547	163	17	]	]	PUNCT
admet-547	163	18	property	property	NOUN
admet-547	163	19	value	value	NOUN
admet-547	163	20	explanation	explanation	NOUN
admet-547	163	21	%	%	NOUN
admet-547	163	22	bound	bind	VERB
admet-547	163	23	hsa	hsa	PROPN
admet-547	163	24	22.90	22.90	NUM
admet-547	163	25	albumin	albumin	ADJ
admet-547	163	26	binding	bind	VERB
admet-547	163	27	%	%	NOUN
admet-547	163	28	bound	bind	VERB
admet-547	163	29	agp	agp	NOUN
admet-547	163	30	45.06	45.06	NUM
admet-547	163	31	glycoprotein	glycoprotein	NOUN
admet-547	163	32	binding	bind	VERB
admet-547	163	33	calc	calc	NOUN
admet-547	163	34	%	%	NOUN
admet-547	163	35	ppb	ppb	VERB
admet-547	163	36	31.40	31.40	NUM
admet-547	163	37	plasma	plasma	NOUN
admet-547	163	38	protein	protein	NOUN
admet-547	163	39	binding	bind	VERB
admet-547	163	40	calc	calc	NOUN
admet-547	163	41	%	%	NOUN
admet-547	163	42	blood	blood	NOUN
admet-547	163	43	23.60	23.60	NUM
admet-547	163	44	blood	blood	NOUN
admet-547	163	45	binding	bind	VERB
admet-547	163	46	chi	chi	PROPN
admet-547	163	47	log	log	PROPN
admet-547	163	48	d2	d2	PROPN
admet-547	163	49	-3.38	-3.38	NUM
admet-547	163	50	lipophilicity	lipophilicity	NOUN
admet-547	163	51	at	at	ADP
admet-547	163	52	ph	ph	PROPN
admet-547	163	53	2	2	NUM
admet-547	163	54	chi	chi	NOUN
admet-547	163	55	log	log	NOUN
admet-547	163	56	d7.4	d7.4	PROPN
admet-547	163	57	-0.16	-0.16	NUM
admet-547	163	58	lipophilicity	lipophilicity	NOUN
admet-547	163	59	at	at	ADP
admet-547	163	60	ph	ph	PROPN
admet-547	163	61	7.4	7.4	NUM
admet-547	163	62	chi	chi	NOUN
admet-547	163	63	log	log	NOUN
admet-547	163	64	d10.5	d10.5	X
admet-547	163	65	0.20	0.20	NUM
admet-547	163	66	lipophilicity	lipophilicity	NOUN
admet-547	163	67	at	at	ADP
admet-547	163	68	ph	ph	PROPN
admet-547	163	69	10.6	10.6	NUM
admet-547	163	70	chi	chi	NOUN
admet-547	163	71	log	log	NOUN
admet-547	163	72	p	p	NOUN
admet-547	163	73	0.20	0.20	NUM
admet-547	163	74	neutral	neutral	ADJ
admet-547	163	75	form	form	NOUN
admet-547	163	76	lipophilicity	lipophilicity	NOUN
admet-547	163	77	iam	iam	PROPN
admet-547	163	78	42.5	42.5	NUM
admet-547	163	79	phospholipid	phospholipid	NOUN
admet-547	163	80	binding	bind	VERB
admet-547	163	81	cad	cad	NOUN
admet-547	163	82	-	-	PUNCT
admet-547	163	83	likeness	likeness	NOUN
admet-547	163	84	49.4	49.4	NUM
admet-547	163	85	phospholipidotic	phospholipidotic	ADJ
admet-547	163	86	potential	potential	ADJ
admet-547	163	87	est	est	X
admet-547	163	88	log	log	NOUN
admet-547	163	89	bb	bb	NOUN
admet-547	163	90	0.22	0.22	NUM
admet-547	163	91	brain	brain	NOUN
admet-547	163	92	to	to	ADP
admet-547	163	93	blood	blood	NOUN
admet-547	163	94	ratio	ratio	NOUN
admet-547	163	95	(	(	PUNCT
admet-547	163	96	log	log	NOUN
admet-547	163	97	)	)	PUNCT
admet-547	163	98	brain	brain	NOUN
admet-547	163	99	to	to	AUX
admet-547	163	100	plasma	plasma	VERB
admet-547	163	101	1.65	1.65	NUM
admet-547	163	102	brain	brain	NOUN
admet-547	163	103	to	to	ADP
admet-547	163	104	plasma	plasma	NOUN
admet-547	163	105	ratio	ratio	NOUN
admet-547	163	106	log	log	NOUN
admet-547	163	107	vd	vd	NOUN
admet-547	163	108	0.89	0.89	NUM
admet-547	163	109	log	log	NOUN
admet-547	163	110	volume	volume	NOUN
admet-547	163	111	of	of	ADP
admet-547	163	112	distribution	distribution	NOUN
admet-547	163	113	vd	vd	NOUN
admet-547	163	114	l	l	X
admet-547	163	115	/	/	SYM
admet-547	163	116	kg	kg	PROPN
admet-547	163	117	7.83	7.83	NUM
admet-547	163	118	volume	volume	NOUN
admet-547	163	119	of	of	ADP
admet-547	163	120	distribution	distribution	NOUN
admet-547	163	121	log	log	NOUN
admet-547	163	122	vdu	vdu	PROPN
admet-547	163	123	1.06	1.06	NUM
admet-547	163	124	log	log	NOUN
admet-547	163	125	unbound	unbound	NOUN
admet-547	163	126	volume	volume	NOUN
admet-547	163	127	of	of	ADP
admet-547	163	128	distribution	distribution	NOUN
admet-547	163	129	vdu	vdu	PROPN
admet-547	163	130	11.5	11.5	NUM
admet-547	163	131	the	the	DET
admet-547	163	132	unbound	unbound	NOUN
admet-547	163	133	volume	volume	NOUN
admet-547	163	134	of	of	ADP
admet-547	163	135	distribution	distribution	NOUN
admet-547	163	136	demax%	demax%	PUNCT
admet-547	163	137	8.74	8.74	NUM
admet-547	163	138	max	max	PROPN
admet-547	163	139	drug	drug	NOUN
admet-547	163	140	efficiency	efficiency	NOUN
admet-547	163	141	mw	mw	VERB
admet-547	163	142	799.00	799.00	NUM
admet-547	163	143	molecular	molecular	ADJ
admet-547	163	144	weight	weight	NOUN
admet-547	163	145	log	log	NOUN
admet-547	163	146	kbrain	kbrain	VERB
admet-547	163	147	0.15	0.15	NUM
admet-547	163	148	brain	brain	NOUN
admet-547	163	149	tissue	tissue	NOUN
admet-547	163	150	partition	partition	NOUN
admet-547	163	151	%	%	NOUN
admet-547	163	152	btb	btb	ADP
admet-547	163	153	58.3	58.3	NUM
admet-547	163	154	brain	brain	NOUN
admet-547	163	155	tissue	tissue	NOUN
admet-547	163	156	binding	bind	VERB
admet-547	163	157	log	log	NOUN
admet-547	163	158	k	k	PROPN
admet-547	163	159	lung	lung	NOUN
admet-547	163	160	tissue	tissue	NOUN
admet-547	163	161	0.51	0.51	NUM
admet-547	163	162	lung	lung	NOUN
admet-547	163	163	tissue	tissue	NOUN
admet-547	163	164	partition	partition	NOUN
admet-547	163	165	%	%	NOUN
admet-547	163	166	lung	lung	NOUN
admet-547	163	167	tissue	tissue	NOUN
admet-547	163	168	binding	bind	VERB
admet-547	163	169	72.3	72.3	NUM
admet-547	163	170	lung	lung	NOUN
admet-547	163	171	tissue	tissue	NOUN
admet-547	163	172	binding	bind	VERB
admet-547	163	173	log	log	NOUN
admet-547	163	174	kp	kp	PROPN
admet-547	163	175	skin	skin	NOUN
admet-547	163	176	-7.10	-7.10	NUM
admet-547	163	177	log	log	NOUN
admet-547	163	178	skin	skin	NOUN
admet-547	163	179	partition	partition	NOUN
admet-547	163	180	log	log	NOUN
admet-547	163	181	kp	kp	PROPN
admet-547	163	182	skin	skin	NOUN
admet-547	163	183	-7.69	-7.69	NOUN
admet-547	163	184	skin	skin	NOUN
admet-547	163	185	partition	partition	NOUN
admet-547	163	186	log	log	NOUN
admet-547	163	187	kp	kp	PROPN
admet-547	163	188	cell	cell	NOUN
admet-547	163	189	0.71	0.71	NUM
admet-547	163	190	log	log	NOUN
admet-547	163	191	cell	cell	NOUN
admet-547	163	192	partition	partition	NOUN
admet-547	163	193	kp	kp	PROPN
admet-547	163	194	cell	cell	VERB
admet-547	163	195	5.2	5.2	NUM
admet-547	163	196	cell	cell	NOUN
admet-547	163	197	partition	partition	NOUN
admet-547	163	198	it	it	PRON
admet-547	163	199	is	be	AUX
admet-547	163	200	well	well	ADV
admet-547	163	201	-	-	PUNCT
admet-547	163	202	known	know	VERB
admet-547	163	203	that	that	SCONJ
admet-547	163	204	plasma	plasma	NOUN
admet-547	163	205	proteases	protease	NOUN
admet-547	163	206	can	can	AUX
admet-547	163	207	hydrolyse	hydrolyse	VERB
admet-547	163	208	peptides	peptide	NOUN
admet-547	163	209	rapidly	rapidly	ADV
admet-547	163	210	and	and	CCONJ
admet-547	163	211	that	that	SCONJ
admet-547	163	212	special	special	ADJ
admet-547	163	213	method	method	NOUN
admet-547	163	214	should	should	AUX
admet-547	163	215	be	be	AUX
admet-547	163	216	applied	apply	VERB
admet-547	163	217	to	to	ADP
admet-547	163	218	the	the	DET
admet-547	163	219	plasma	plasma	NOUN
admet-547	163	220	concentration	concentration	NOUN
admet-547	163	221	determination	determination	NOUN
admet-547	164	1	[	[	X
admet-547	164	2	28,29	28,29	X
admet-547	164	3	]	]	X
admet-547	164	4	.	.	PUNCT
admet-547	165	1	gm6	gm6	PROPN
admet-547	165	2	showed	show	VERB
admet-547	165	3	15	15	NUM
admet-547	165	4	min	min	NOUN
admet-547	165	5	half	half	ADJ
admet-547	165	6	-	-	PUNCT
admet-547	165	7	life	life	NOUN
admet-547	165	8	in	in	ADP
admet-547	165	9	vitro	vitro	X
admet-547	165	10	in	in	ADP
admet-547	165	11	human	human	ADJ
admet-547	165	12	blood	blood	NOUN
admet-547	165	13	.	.	PUNCT
admet-547	166	1	it	it	PRON
admet-547	166	2	has	have	AUX
admet-547	166	3	been	be	AUX
admet-547	166	4	also	also	ADV
admet-547	166	5	reported	report	VERB
admet-547	166	6	that	that	SCONJ
admet-547	166	7	some	some	DET
admet-547	166	8	therapeutic	therapeutic	ADJ
admet-547	166	9	peptides	peptide	NOUN
admet-547	166	10	could	could	AUX
admet-547	166	11	not	not	PART
admet-547	166	12	be	be	AUX
admet-547	166	13	detected	detect	VERB
admet-547	166	14	in	in	ADP
admet-547	166	15	the	the	DET
admet-547	166	16	plasma	plasma	NOUN
admet-547	166	17	but	but	CCONJ
admet-547	166	18	they	they	PRON
admet-547	166	19	still	still	ADV
admet-547	166	20	had	have	VERB
admet-547	166	21	a	a	DET
admet-547	166	22	long	long	ADV
admet-547	166	23	-	-	PUNCT
admet-547	166	24	lasting	last	VERB
admet-547	166	25	pharmacological	pharmacological	ADJ
admet-547	166	26	effect	effect	NOUN
admet-547	167	1	[	[	X
admet-547	167	2	30	30	NUM
admet-547	167	3	]	]	PUNCT
admet-547	167	4	.	.	PUNCT
admet-547	168	1	there	there	PRON
admet-547	168	2	are	be	VERB
admet-547	168	3	various	various	ADJ
admet-547	168	4	methods	method	NOUN
admet-547	168	5	for	for	ADP
admet-547	168	6	increasing	increase	VERB
admet-547	168	7	the	the	DET
admet-547	168	8	plasma	plasma	NOUN
admet-547	168	9	half	half	ADJ
admet-547	168	10	-	-	PUNCT
admet-547	168	11	life	life	NOUN
admet-547	168	12	of	of	ADP
admet-547	168	13	peptides	peptide	NOUN
admet-547	168	14	such	such	ADJ
admet-547	168	15	as	as	ADP
admet-547	168	16	replacing	replace	VERB
admet-547	168	17	l	l	ADJ
admet-547	168	18	-	-	ADJ
admet-547	168	19	amino	amino	ADJ
admet-547	168	20	acids	acid	NOUN
admet-547	168	21	to	to	ADP
admet-547	168	22	damino	damino	PROPN
admet-547	168	23	acids	acid	NOUN
admet-547	168	24	,	,	PUNCT
admet-547	168	25	blocking	block	VERB
admet-547	168	26	the	the	DET
admet-547	168	27	n	n	NOUN
admet-547	168	28	or	or	CCONJ
admet-547	168	29	c	c	NOUN
admet-547	168	30	terminals	terminal	NOUN
admet-547	168	31	,	,	PUNCT
admet-547	168	32	conjugations	conjugation	NOUN
admet-547	168	33	to	to	ADP
admet-547	168	34	macromolecules	macromolecule	NOUN
admet-547	168	35	like	like	ADP
admet-547	168	36	peg	peg	NOUN
admet-547	168	37	and	and	CCONJ
admet-547	168	38	cyclisation	cyclisation	NOUN
admet-547	168	39	[	[	X
admet-547	168	40	27	27	NUM
admet-547	168	41	]	]	PUNCT
admet-547	168	42	.	.	PUNCT
admet-547	169	1	other	other	ADJ
admet-547	169	2	approaches	approach	NOUN
admet-547	169	3	such	such	ADJ
admet-547	169	4	as	as	ADP
admet-547	169	5	increasing	increase	VERB
admet-547	169	6	the	the	DET
admet-547	169	7	albumin	albumin	ADJ
admet-547	169	8	binding	binding	NOUN
admet-547	169	9	are	be	AUX
admet-547	169	10	also	also	ADV
admet-547	169	11	used	use	VERB
admet-547	169	12	to	to	PART
admet-547	169	13	improve	improve	VERB
admet-547	169	14	the	the	DET
admet-547	169	15	physicochemical	physicochemical	NOUN
admet-547	169	16	and	and	CCONJ
admet-547	169	17	in	in	ADP
admet-547	169	18	vivo	vivo	ADJ
admet-547	169	19	admet	admet	NOUN
admet-547	169	20	properties	property	NOUN
admet-547	169	21	of	of	ADP
admet-547	169	22	peptides	peptide	NOUN
admet-547	169	23	[	[	X
admet-547	169	24	31	31	NUM
admet-547	169	25	]	]	PUNCT
admet-547	169	26	in	in	ADP
admet-547	169	27	order	order	NOUN
admet-547	169	28	to	to	PART
admet-547	169	29	open	open	VERB
admet-547	169	30	up	up	ADP
admet-547	169	31	new	new	ADJ
admet-547	169	32	modalities	modality	NOUN
admet-547	169	33	in	in	ADP
admet-547	169	34	drug	drug	NOUN
admet-547	169	35	discovery	discovery	NOUN
admet-547	169	36	.	.	PUNCT
admet-547	170	1	with	with	ADP
admet-547	170	2	gm6	gm6	PROPN
admet-547	170	3	,	,	PUNCT
admet-547	170	4	the	the	DET
admet-547	170	5	idea	idea	NOUN
admet-547	170	6	was	be	AUX
admet-547	170	7	not	not	PART
admet-547	170	8	to	to	PART
admet-547	170	9	change	change	VERB
admet-547	170	10	the	the	DET
admet-547	170	11	peptide	peptide	NOUN
admet-547	170	12	structure	structure	NOUN
admet-547	170	13	but	but	CCONJ
admet-547	170	14	to	to	PART
admet-547	170	15	remain	remain	VERB
admet-547	170	16	close	close	ADJ
admet-547	170	17	to	to	ADP
admet-547	170	18	the	the	DET
admet-547	170	19	endogenous	endogenous	ADJ
admet-547	170	20	mntf	mntf	NOUN
admet-547	170	21	using	use	VERB
admet-547	170	22	the	the	DET
admet-547	170	23	6	6	NUM
admet-547	170	24	-	-	PUNCT
admet-547	170	25	amino	amino	NOUN
admet-547	170	26	acid	acid	NOUN
admet-547	170	27	sequence	sequence	NOUN
admet-547	170	28	which	which	PRON
admet-547	170	29	was	be	AUX
admet-547	170	30	thought	think	VERB
admet-547	170	31	to	to	PART
admet-547	170	32	be	be	AUX
admet-547	170	33	responsible	responsible	ADJ
admet-547	170	34	for	for	ADP
admet-547	170	35	the	the	DET
admet-547	170	36	neuroprotective	neuroprotective	ADJ
admet-547	170	37	effect	effect	NOUN
admet-547	170	38	.	.	PUNCT
admet-547	171	1	klara	klara	PROPN
admet-547	171	2	valko	valko	PROPN
admet-547	171	3	et	et	PROPN
admet-547	171	4	al	al	PROPN
admet-547	171	5	.	.	PROPN
admet-547	171	6	admet	admet	PROPN
admet-547	171	7	&	&	CCONJ
admet-547	171	8	dmpk	dmpk	PROPN
admet-547	171	9	6(2	6(2	NUM
admet-547	171	10	)	)	PUNCT
admet-547	171	11	(	(	PUNCT
admet-547	171	12	2018	2018	NUM
admet-547	171	13	)	)	PUNCT
admet-547	171	14	176	176	NUM
admet-547	171	15	-	-	SYM
admet-547	171	16	189	189	NUM
admet-547	171	17	184	184	NUM
admet-547	171	18	figure	figure	NOUN
admet-547	171	19	1	1	NUM
admet-547	171	20	.	.	X
admet-547	171	21	boxplot	boxplot	NOUN
admet-547	171	22	of	of	ADP
admet-547	171	23	the	the	DET
admet-547	171	24	average	average	ADJ
admet-547	171	25	estimated	estimate	VERB
admet-547	171	26	log	log	NOUN
admet-547	171	27	kbb	kbb	PROPN
admet-547	171	28	values	value	NOUN
admet-547	171	29	of	of	ADP
admet-547	171	30	marketed	market	VERB
admet-547	171	31	drugs	drug	NOUN
admet-547	171	32	,	,	PUNCT
admet-547	171	33	drugs	drug	NOUN
admet-547	171	34	that	that	PRON
admet-547	171	35	enter	enter	VERB
admet-547	171	36	into	into	ADP
admet-547	171	37	the	the	DET
admet-547	171	38	central	central	ADJ
admet-547	171	39	nervous	nervous	ADJ
admet-547	171	40	system	system	NOUN
admet-547	171	41	(	(	PUNCT
admet-547	171	42	cns	cns	NOUN
admet-547	171	43	)	)	PUNCT
admet-547	171	44	and	and	CCONJ
admet-547	171	45	inhaled	inhaled	ADJ
admet-547	171	46	drugs	drug	NOUN
admet-547	171	47	,	,	PUNCT
admet-547	171	48	as	as	ADV
admet-547	171	49	well	well	ADV
admet-547	171	50	as	as	ADP
admet-547	171	51	gm6	gm6	PROPN
admet-547	171	52	.	.	PUNCT
admet-547	172	1	the	the	DET
admet-547	172	2	estimated	estimate	VERB
admet-547	172	3	brain	brain	NOUN
admet-547	172	4	to	to	AUX
admet-547	172	5	plasma	plasma	NOUN
admet-547	172	6	total	total	ADJ
admet-547	172	7	concentration	concentration	NOUN
admet-547	172	8	ratio	ratio	NOUN
admet-547	172	9	was	be	AUX
admet-547	172	10	calculated	calculate	VERB
admet-547	172	11	using	use	VERB
admet-547	172	12	the	the	DET
admet-547	172	13	equations	equation	NOUN
admet-547	172	14	given	give	VERB
admet-547	172	15	in	in	ADP
admet-547	172	16	table	table	NOUN
admet-547	172	17	1	1	NUM
admet-547	172	18	.	.	PUNCT
admet-547	172	19	figure	figure	NOUN
admet-547	172	20	2	2	NUM
admet-547	172	21	.	.	PUNCT
admet-547	173	1	the	the	DET
admet-547	173	2	plot	plot	NOUN
admet-547	173	3	of	of	ADP
admet-547	173	4	the	the	DET
admet-547	173	5	estimated	estimate	VERB
admet-547	173	6	brain	brain	NOUN
admet-547	173	7	to	to	ADP
admet-547	173	8	blood	blood	NOUN
admet-547	173	9	ratio	ratio	NOUN
admet-547	173	10	(	(	PUNCT
admet-547	173	11	log	log	PROPN
admet-547	173	12	kbb	kbb	PROPN
admet-547	173	13	)	)	PUNCT
admet-547	173	14	and	and	CCONJ
admet-547	173	15	the	the	DET
admet-547	173	16	steady	steady	ADJ
admet-547	173	17	-	-	PUNCT
admet-547	173	18	state	state	NOUN
admet-547	173	19	volume	volume	NOUN
admet-547	173	20	of	of	ADP
admet-547	173	21	distribution	distribution	NOUN
admet-547	173	22	(	(	PUNCT
admet-547	173	23	log	log	VERB
admet-547	173	24	vdss	vdss	ADV
admet-547	173	25	)	)	PUNCT
admet-547	173	26	of	of	ADP
admet-547	173	27	marketed	market	VERB
admet-547	173	28	drugs	drug	NOUN
admet-547	173	29	that	that	PRON
admet-547	173	30	enter	enter	VERB
admet-547	173	31	into	into	ADP
admet-547	173	32	the	the	DET
admet-547	173	33	cns	cns	NOUN
admet-547	173	34	.	.	PUNCT
admet-547	174	1	based	base	VERB
admet-547	174	2	on	on	ADP
admet-547	174	3	the	the	DET
admet-547	174	4	measured	measure	VERB
admet-547	174	5	physicochemical	physicochemical	ADJ
admet-547	174	6	and	and	CCONJ
admet-547	174	7	biomimetic	biomimetic	ADJ
admet-547	174	8	properties	property	NOUN
admet-547	174	9	listed	list	VERB
admet-547	174	10	in	in	ADP
admet-547	174	11	table	table	NOUN
admet-547	174	12	2	2	NUM
admet-547	174	13	,	,	PUNCT
admet-547	174	14	it	it	PRON
admet-547	174	15	can	can	AUX
admet-547	174	16	be	be	AUX
admet-547	174	17	seen	see	VERB
admet-547	174	18	that	that	SCONJ
admet-547	174	19	gm6	gm6	PROPN
admet-547	174	20	is	be	AUX
admet-547	174	21	predicted	predict	VERB
admet-547	174	22	to	to	PART
admet-547	174	23	have	have	VERB
admet-547	174	24	high	high	ADJ
admet-547	174	25	cell	cell	NOUN
admet-547	174	26	partition	partition	NOUN
admet-547	174	27	(	(	PUNCT
admet-547	174	28	kpcell	kpcell	NOUN
admet-547	174	29	=	=	SYM
admet-547	174	30	5.2	5.2	NUM
admet-547	174	31	)	)	PUNCT
admet-547	174	32	which	which	PRON
admet-547	174	33	means	mean	VERB
admet-547	174	34	5	5	NUM
admet-547	174	35	times	time	NOUN
admet-547	174	36	higher	high	ADJ
admet-547	174	37	concentration	concentration	NOUN
admet-547	174	38	inside	inside	ADP
admet-547	174	39	the	the	DET
admet-547	174	40	cells	cell	NOUN
admet-547	174	41	that	that	PRON
admet-547	174	42	outside	outside	ADP
admet-547	174	43	the	the	DET
admet-547	174	44	cells	cell	NOUN
admet-547	174	45	.	.	PUNCT
admet-547	175	1	the	the	DET
admet-547	175	2	model	model	NOUN
admet-547	175	3	has	have	AUX
admet-547	175	4	been	be	AUX
admet-547	175	5	developed	develop	VERB
admet-547	175	6	using	use	VERB
admet-547	175	7	300	300	NUM
admet-547	175	8	compounds	compound	NOUN
admet-547	175	9	data	datum	NOUN
admet-547	175	10	that	that	PRON
admet-547	175	11	were	be	AUX
admet-547	175	12	equilibrated	equilibrate	VERB
admet-547	175	13	with	with	ADP
admet-547	175	14	hela	hela	ADJ
admet-547	175	15	cells	cell	NOUN
admet-547	175	16	and	and	CCONJ
admet-547	175	17	measured	measure	VERB
admet-547	175	18	the	the	DET
admet-547	175	19	intracellular	intracellular	ADJ
admet-547	175	20	concentration	concentration	NOUN
admet-547	176	1	[	[	X
admet-547	176	2	23	23	NUM
admet-547	176	3	]	]	PUNCT
admet-547	176	4	.	.	PUNCT
admet-547	177	1	hela	hela	PROPN
admet-547	177	2	cells	cell	NOUN
admet-547	177	3	do	do	AUX
admet-547	177	4	not	not	PART
admet-547	177	5	contain	contain	VERB
admet-547	177	6	active	active	ADJ
admet-547	177	7	transporters	transporter	NOUN
admet-547	177	8	,	,	PUNCT
admet-547	177	9	so	so	SCONJ
admet-547	177	10	it	it	PRON
admet-547	177	11	can	can	AUX
admet-547	177	12	be	be	AUX
admet-547	177	13	assumed	assume	VERB
admet-547	177	14	that	that	SCONJ
admet-547	177	15	this	this	PRON
admet-547	177	16	is	be	AUX
admet-547	177	17	the	the	DET
admet-547	177	18	passive	passive	ADJ
admet-547	177	19	partition	partition	NOUN
admet-547	177	20	of	of	ADP
admet-547	177	21	gm6	gm6	PROPN
admet-547	177	22	into	into	ADP
admet-547	177	23	cells	cell	NOUN
admet-547	177	24	.	.	PUNCT
admet-547	178	1	quantitative	quantitative	ADJ
admet-547	178	2	immunofluorescence	immunofluorescence	NOUN
admet-547	178	3	imaging	image	VERB
admet-547	178	4	the	the	DET
admet-547	178	5	results	result	NOUN
admet-547	178	6	of	of	ADP
admet-547	178	7	the	the	DET
admet-547	178	8	quantitative	quantitative	ADJ
admet-547	178	9	imaging	imaging	NOUN
admet-547	178	10	experiments	experiment	NOUN
admet-547	178	11	gave	give	VERB
admet-547	178	12	a	a	DET
admet-547	178	13	very	very	ADV
admet-547	178	14	good	good	ADJ
admet-547	178	15	indication	indication	NOUN
admet-547	178	16	that	that	SCONJ
admet-547	178	17	gm6	gm6	PROPN
admet-547	178	18	associates	associate	NOUN
admet-547	178	19	with	with	ADP
admet-547	178	20	cells	cell	NOUN
admet-547	178	21	well	well	ADV
admet-547	178	22	,	,	PUNCT
admet-547	178	23	especially	especially	ADV
admet-547	178	24	to	to	ADP
admet-547	178	25	ips	ips	NOUN
admet-547	178	26	-	-	PUNCT
admet-547	178	27	derived	derive	VERB
admet-547	178	28	neurons	neuron	NOUN
admet-547	178	29	.	.	PUNCT
admet-547	179	1	gm6	gm6	PROPN
admet-547	179	2	demonstrated	demonstrate	VERB
admet-547	179	3	quantifiable	quantifiable	ADJ
admet-547	179	4	labelling	labelling	NOUN
admet-547	179	5	of	of	ADP
admet-547	179	6	cellular	cellular	ADJ
admet-547	179	7	structures	structure	NOUN
admet-547	179	8	in	in	ADP
admet-547	179	9	all	all	PRON
admet-547	179	10	of	of	ADP
admet-547	179	11	the	the	DET
admet-547	179	12	cell	cell	NOUN
admet-547	179	13	types	type	NOUN
admet-547	179	14	tested	test	VERB
admet-547	179	15	with	with	ADP
admet-547	179	16	chicken	chicken	NOUN
admet-547	179	17	anti	anti	ADJ
admet-547	179	18	-	-	ADJ
admet-547	179	19	gm6	gm6	INTJ
admet-547	179	20	(	(	PUNCT
admet-547	179	21	genervon	genervon	PROPN
admet-547	179	22	)	)	PUNCT
admet-547	179	23	.	.	PUNCT
admet-547	180	1	while	while	SCONJ
admet-547	180	2	it	it	PRON
admet-547	180	3	is	be	AUX
admet-547	180	4	difficult	difficult	ADJ
admet-547	180	5	to	to	PART
admet-547	180	6	determine	determine	VERB
admet-547	180	7	whether	whether	SCONJ
admet-547	180	8	gm6	gm6	PROPN
admet-547	180	9	was	be	AUX
admet-547	180	10	restricted	restrict	VERB
admet-547	180	11	to	to	ADP
admet-547	180	12	the	the	DET
admet-547	180	13	surface	surface	NOUN
admet-547	180	14	of	of	ADP
admet-547	180	15	the	the	DET
admet-547	180	16	cells	cell	NOUN
admet-547	180	17	that	that	PRON
admet-547	180	18	it	it	PRON
admet-547	180	19	interacted	interact	VERB
admet-547	180	20	with	with	ADP
admet-547	180	21	or	or	CCONJ
admet-547	180	22	was	be	AUX
admet-547	180	23	internalized	internalize	VERB
admet-547	180	24	or	or	CCONJ
admet-547	180	25	degraded	degraded	ADJ
admet-547	180	26	,	,	PUNCT
admet-547	180	27	based	base	VERB
admet-547	180	28	on	on	ADP
admet-547	180	29	the	the	DET
admet-547	180	30	time	time	NOUN
admet-547	180	31	and	and	CCONJ
admet-547	180	32	dose	dose	NOUN
admet-547	180	33	-	-	PUNCT
admet-547	180	34	dependent	dependent	ADJ
admet-547	180	35	effects	effect	NOUN
admet-547	180	36	on	on	ADP
admet-547	180	37	markers	marker	NOUN
admet-547	180	38	,	,	PUNCT
admet-547	180	39	it	it	PRON
admet-547	180	40	did	do	AUX
admet-547	180	41	suggest	suggest	VERB
admet-547	180	42	that	that	SCONJ
admet-547	180	43	gm6	gm6	PROPN
admet-547	180	44	was	be	AUX
admet-547	180	45	able	able	ADJ
admet-547	180	46	to	to	PART
admet-547	180	47	elicit	elicit	VERB
admet-547	180	48	cellular	cellular	ADJ
admet-547	180	49	responses	response	NOUN
admet-547	180	50	that	that	PRON
admet-547	180	51	could	could	AUX
admet-547	180	52	be	be	AUX
admet-547	180	53	a	a	DET
admet-547	180	54	result	result	NOUN
admet-547	180	55	of	of	ADP
admet-547	180	56	cell	cell	NOUN
admet-547	180	57	surface	surface	NOUN
admet-547	180	58	binding	bind	VERB
admet-547	180	59	,	,	PUNCT
admet-547	180	60	via	via	ADP
admet-547	180	61	uptake	uptake	NOUN
admet-547	180	62	or	or	CCONJ
admet-547	180	63	via	via	ADP
admet-547	180	64	a	a	DET
admet-547	180	65	combination	combination	NOUN
admet-547	180	66	of	of	ADP
admet-547	180	67	admet	admet	PROPN
admet-547	180	68	&	&	CCONJ
admet-547	180	69	dmpk	dmpk	PROPN
admet-547	180	70	6(2	6(2	NUM
admet-547	180	71	)	)	PUNCT
admet-547	180	72	(	(	PUNCT
admet-547	180	73	2018	2018	NUM
admet-547	180	74	)	)	PUNCT
admet-547	180	75	176	176	NUM
admet-547	180	76	-	-	SYM
admet-547	180	77	189	189	NUM
admet-547	180	78	in	in	ADP
admet-547	180	79	vitro	vitro	X
admet-547	180	80	and	and	CCONJ
admet-547	180	81	in	in	ADP
admet-547	180	82	vivo	vivo	ADJ
admet-547	180	83	characterization	characterization	NOUN
admet-547	180	84	of	of	ADP
admet-547	180	85	gm6	gm6	PROPN
admet-547	180	86	doi	doi	NOUN
admet-547	180	87	:	:	PUNCT
admet-547	180	88	10.5599	10.5599	NUM
admet-547	180	89	/	/	SYM
admet-547	180	90	admet.547	admet.547	NOUN
admet-547	180	91	185	185	NUM
admet-547	180	92	both	both	DET
admet-547	180	93	processes	process	NOUN
admet-547	180	94	.	.	PUNCT
admet-547	181	1	it	it	PRON
admet-547	181	2	was	be	AUX
admet-547	181	3	found	find	VERB
admet-547	181	4	that	that	SCONJ
admet-547	181	5	an	an	DET
admet-547	181	6	increase	increase	NOUN
admet-547	181	7	in	in	ADP
admet-547	181	8	gm6	gm6	PROPN
admet-547	181	9	abundance	abundance	NOUN
admet-547	181	10	in	in	ADP
admet-547	181	11	all	all	DET
admet-547	181	12	cell	cell	NOUN
admet-547	181	13	types	type	NOUN
admet-547	181	14	could	could	AUX
admet-547	181	15	be	be	AUX
admet-547	181	16	quantified	quantify	VERB
admet-547	181	17	.	.	PUNCT
admet-547	182	1	the	the	DET
admet-547	182	2	response	response	NOUN
admet-547	182	3	of	of	ADP
admet-547	182	4	gm6	gm6	PROPN
admet-547	182	5	treatment	treatment	NOUN
admet-547	182	6	on	on	ADP
admet-547	182	7	the	the	DET
admet-547	182	8	gabaergic	gabaergic	ADJ
admet-547	182	9	neurons	neuron	NOUN
admet-547	182	10	was	be	AUX
admet-547	182	11	much	much	ADV
admet-547	182	12	more	more	ADV
admet-547	182	13	significant	significant	ADJ
admet-547	182	14	than	than	ADP
admet-547	182	15	on	on	ADP
admet-547	182	16	the	the	DET
admet-547	182	17	hepatocytes	hepatocyte	NOUN
admet-547	182	18	,	,	PUNCT
admet-547	182	19	which	which	PRON
admet-547	182	20	suggested	suggest	VERB
admet-547	182	21	a	a	DET
admet-547	182	22	specific	specific	ADJ
admet-547	182	23	affinity	affinity	NOUN
admet-547	182	24	of	of	ADP
admet-547	182	25	gm6	gm6	PROPN
admet-547	182	26	to	to	ADP
admet-547	182	27	tissues	tissue	NOUN
admet-547	182	28	of	of	ADP
admet-547	182	29	the	the	DET
admet-547	182	30	nervous	nervous	ADJ
admet-547	182	31	system	system	NOUN
admet-547	182	32	and	and	CCONJ
admet-547	182	33	less	less	ADV
admet-547	182	34	so	so	ADV
admet-547	182	35	to	to	ADP
admet-547	182	36	the	the	DET
admet-547	182	37	liver	liver	NOUN
admet-547	182	38	.	.	PUNCT
admet-547	183	1	based	base	VERB
admet-547	183	2	on	on	ADP
admet-547	183	3	the	the	DET
admet-547	183	4	study	study	NOUN
admet-547	183	5	we	we	PRON
admet-547	183	6	can	can	AUX
admet-547	183	7	hypothesize	hypothesize	VERB
admet-547	183	8	that	that	SCONJ
admet-547	183	9	this	this	DET
admet-547	183	10	cationic	cationic	ADJ
admet-547	183	11	peptide	peptide	NOUN
admet-547	183	12	,	,	PUNCT
admet-547	183	13	gm6	gm6	PROPN
admet-547	183	14	,	,	PUNCT
admet-547	183	15	crosses	cross	VERB
admet-547	183	16	the	the	DET
admet-547	183	17	cell	cell	NOUN
admet-547	183	18	membrane	membrane	NOUN
admet-547	183	19	and	and	CCONJ
admet-547	183	20	enters	enter	VERB
admet-547	183	21	the	the	DET
admet-547	183	22	cytoplasm	cytoplasm	NOUN
admet-547	183	23	.	.	PUNCT
admet-547	184	1	figure	figure	NOUN
admet-547	184	2	3	3	NUM
admet-547	184	3	shows	show	VERB
admet-547	184	4	representative	representative	ADJ
admet-547	184	5	immunofluorescence	immunofluorescence	NOUN
admet-547	184	6	images	image	NOUN
admet-547	184	7	obtained	obtain	VERB
admet-547	184	8	in	in	ADP
admet-547	184	9	gaba	gaba	PROPN
admet-547	184	10	neuron	neuron	NOUN
admet-547	184	11	cells	cell	NOUN
admet-547	184	12	after	after	ADP
admet-547	184	13	treatment	treatment	NOUN
admet-547	184	14	of	of	ADP
admet-547	184	15	gm6	gm6	PROPN
admet-547	184	16	.	.	PUNCT
admet-547	185	1	figure	figure	NOUN
admet-547	185	2	3	3	NUM
admet-547	185	3	.	.	PUNCT
admet-547	185	4	immunofluorescence	immunofluorescence	NOUN
admet-547	185	5	images	image	NOUN
admet-547	185	6	obtained	obtain	VERB
admet-547	185	7	after	after	ADP
admet-547	185	8	treating	treat	VERB
admet-547	185	9	the	the	DET
admet-547	185	10	gaba	gaba	PROPN
admet-547	185	11	neuron	neuron	NOUN
admet-547	185	12	cells	cell	NOUN
admet-547	185	13	with	with	ADP
admet-547	185	14	1	1	NUM
admet-547	185	15	mm	mm	NOUN
admet-547	185	16	gm6	gm6	PROPN
admet-547	185	17	or	or	CCONJ
admet-547	185	18	pbsonly	pbsonly	ADV
admet-547	185	19	control	control	NOUN
admet-547	185	20	.	.	PUNCT
admet-547	186	1	(	(	PUNCT
admet-547	186	2	top	top	ADJ
admet-547	186	3	row	row	NOUN
admet-547	186	4	shows	show	NOUN
admet-547	186	5	staining	stain	VERB
admet-547	186	6	of	of	ADP
admet-547	186	7	human	human	ADJ
admet-547	186	8	ips	ip	NOUN
admet-547	186	9	-	-	PUNCT
admet-547	186	10	derived	derive	VERB
admet-547	186	11	gabaergic	gabaergic	ADJ
admet-547	186	12	neurons	neuron	NOUN
admet-547	186	13	treated	treat	VERB
admet-547	186	14	with	with	ADP
admet-547	186	15	1	1	NUM
admet-547	186	16	mm	mm	NOUN
admet-547	186	17	gm6	gm6	PROPN
admet-547	186	18	for	for	ADP
admet-547	186	19	15	15	NUM
admet-547	186	20	minutes	minute	NOUN
admet-547	186	21	while	while	SCONJ
admet-547	186	22	the	the	DET
admet-547	186	23	bottom	bottom	NOUN
admet-547	186	24	row	row	NOUN
admet-547	186	25	shows	show	VERB
admet-547	186	26	control	control	PROPN
admet-547	186	27	pbs	pbs	PROPN
admet-547	186	28	-	-	PUNCT
admet-547	186	29	treated	treat	VERB
admet-547	186	30	neurons	neuron	NOUN
admet-547	186	31	.	.	PUNCT
admet-547	187	1	leftmost	leftmost	ADJ
admet-547	187	2	panels	panel	NOUN
admet-547	187	3	show	show	VERB
admet-547	187	4	hoechst	hoechst	ADJ
admet-547	187	5	staining	stain	VERB
admet-547	187	6	that	that	PRON
admet-547	187	7	identifies	identify	VERB
admet-547	187	8	neuronal	neuronal	ADJ
admet-547	187	9	nuclei	nucleus	NOUN
admet-547	187	10	.	.	PUNCT
admet-547	188	1	panels	panel	NOUN
admet-547	188	2	in	in	ADP
admet-547	188	3	the	the	DET
admet-547	188	4	middle	middle	ADJ
admet-547	188	5	column	column	NOUN
admet-547	188	6	show	show	VERB
admet-547	188	7	detection	detection	NOUN
admet-547	188	8	of	of	ADP
admet-547	188	9	gm6	gm6	PROPN
admet-547	188	10	in	in	ADP
admet-547	188	11	the	the	DET
admet-547	188	12	same	same	ADJ
admet-547	188	13	cells	cell	NOUN
admet-547	188	14	using	use	VERB
admet-547	188	15	an	an	DET
admet-547	188	16	anti	anti	ADJ
admet-547	188	17	-	-	ADJ
admet-547	188	18	gm6	gm6	ADJ
admet-547	188	19	antibody	antibody	NOUN
admet-547	188	20	while	while	SCONJ
admet-547	188	21	columns	column	NOUN
admet-547	188	22	to	to	ADP
admet-547	188	23	the	the	DET
admet-547	188	24	right	right	ADJ
admet-547	188	25	show	show	NOUN
admet-547	188	26	corresponding	correspond	VERB
admet-547	188	27	insulin	insulin	NOUN
admet-547	188	28	receptor	receptor	NOUN
admet-547	188	29	staining	stain	VERB
admet-547	188	30	intensity	intensity	NOUN
admet-547	188	31	,	,	PUNCT
admet-547	188	32	which	which	PRON
admet-547	188	33	has	have	AUX
admet-547	188	34	been	be	AUX
admet-547	188	35	included	include	VERB
admet-547	188	36	to	to	PART
admet-547	188	37	show	show	VERB
admet-547	188	38	the	the	DET
admet-547	188	39	location	location	NOUN
admet-547	188	40	of	of	ADP
admet-547	188	41	the	the	DET
admet-547	188	42	cell	cell	NOUN
admet-547	188	43	bodies	body	NOUN
admet-547	188	44	and	and	CCONJ
admet-547	188	45	neurites	neurite	NOUN
admet-547	188	46	.	.	PUNCT
admet-547	189	1	red	red	ADJ
admet-547	189	2	arrows	arrow	NOUN
admet-547	189	3	show	show	VERB
admet-547	189	4	gm6	gm6	PROPN
admet-547	189	5	in	in	ADP
admet-547	189	6	the	the	DET
admet-547	189	7	cell	cell	NOUN
admet-547	189	8	body	body	NOUN
admet-547	189	9	while	while	SCONJ
admet-547	189	10	yellow	yellow	ADJ
admet-547	189	11	arrows	arrow	NOUN
admet-547	189	12	show	show	VERB
admet-547	189	13	gm6	gm6	PRON
admet-547	189	14	puncta	puncta	NOUN
admet-547	189	15	localized	localize	VERB
admet-547	189	16	to	to	ADP
admet-547	189	17	neurites	neurite	NOUN
admet-547	189	18	.	.	PUNCT
admet-547	190	1	in	in	ADP
admet-547	190	2	some	some	DET
admet-547	190	3	cases	case	NOUN
admet-547	190	4	,	,	PUNCT
admet-547	190	5	staining	stain	VERB
admet-547	190	6	of	of	ADP
admet-547	190	7	gm6	gm6	PROPN
admet-547	190	8	and	and	CCONJ
admet-547	190	9	insr	insr	NOUN
admet-547	190	10	is	be	AUX
admet-547	190	11	coincident	coincident	ADJ
admet-547	190	12	.	.	PUNCT
admet-547	190	13	)	)	PUNCT
admet-547	191	1	results	result	NOUN
admet-547	191	2	of	of	ADP
admet-547	191	3	the	the	DET
admet-547	191	4	in	in	ADP
admet-547	191	5	vivo	vivo	ADJ
admet-547	191	6	brain	brain	NOUN
admet-547	191	7	penetration	penetration	NOUN
admet-547	191	8	studies	study	NOUN
admet-547	191	9	in	in	ADP
admet-547	191	10	mice	mouse	NOUN
admet-547	191	11	elisa	elisa	VERB
admet-547	191	12	assays	assay	NOUN
admet-547	191	13	with	with	ADP
admet-547	191	14	brain	brain	NOUN
admet-547	191	15	homogenate	homogenate	NOUN
admet-547	191	16	supernatant	supernatant	NOUN
admet-547	191	17	detected	detect	VERB
admet-547	191	18	gm6	gm6	PROPN
admet-547	191	19	at	at	ADP
admet-547	191	20	statistically	statistically	ADV
admet-547	191	21	significant	significant	ADJ
admet-547	191	22	levels	level	NOUN
admet-547	191	23	,	,	PUNCT
admet-547	191	24	at	at	ADP
admet-547	191	25	all	all	DET
admet-547	191	26	doses	dose	NOUN
admet-547	191	27	,	,	PUNCT
admet-547	191	28	compared	compare	VERB
admet-547	191	29	to	to	ADP
admet-547	191	30	the	the	DET
admet-547	191	31	control	control	NOUN
admet-547	191	32	(	(	PUNCT
admet-547	191	33	p=0.0001	p=0.0001	PROPN
admet-547	191	34	)	)	PUNCT
admet-547	191	35	as	as	SCONJ
admet-547	191	36	shown	show	VERB
admet-547	191	37	in	in	ADP
admet-547	191	38	figure	figure	NOUN
admet-547	191	39	4	4	NUM
admet-547	191	40	.	.	PUNCT
admet-547	192	1	the	the	DET
admet-547	192	2	vehicle	vehicle	NOUN
admet-547	192	3	group	group	NOUN
admet-547	192	4	has	have	VERB
admet-547	192	5	some	some	DET
admet-547	192	6	detection	detection	NOUN
admet-547	192	7	of	of	ADP
admet-547	192	8	gm6	gm6	PROPN
admet-547	192	9	(	(	PUNCT
admet-547	192	10	0.4050	0.4050	NUM
admet-547	192	11	µm	µm	NOUN
admet-547	192	12	)	)	PUNCT
admet-547	192	13	.	.	PUNCT
admet-547	193	1	the	the	DET
admet-547	193	2	0.2	0.2	NUM
admet-547	193	3	mg	mg	PROPN
admet-547	193	4	/	/	SYM
admet-547	193	5	kg	kg	PROPN
admet-547	193	6	group	group	NOUN
admet-547	193	7	has	have	VERB
admet-547	193	8	1.76	1.76	NUM
admet-547	193	9	µm	µm	NOUN
admet-547	193	10	,	,	PUNCT
admet-547	193	11	the	the	DET
admet-547	193	12	2.0	2.0	NUM
admet-547	193	13	mg	mg	PROPN
admet-547	193	14	/	/	SYM
admet-547	193	15	kg	kg	PROPN
admet-547	193	16	group	group	NOUN
admet-547	193	17	has	have	VERB
admet-547	193	18	12.92	12.92	NUM
admet-547	193	19	µm	µm	NOUN
admet-547	193	20	.	.	PUNCT
admet-547	194	1	if	if	SCONJ
admet-547	194	2	we	we	PRON
admet-547	194	3	subtract	subtract	VERB
admet-547	194	4	the	the	DET
admet-547	194	5	gm6	gm6	PROPN
admet-547	194	6	in	in	ADP
admet-547	194	7	the	the	DET
admet-547	194	8	vehicle	vehicle	NOUN
admet-547	194	9	group	group	NOUN
admet-547	194	10	,	,	PUNCT
admet-547	194	11	the	the	DET
admet-547	194	12	net	net	ADJ
admet-547	194	13	increase	increase	NOUN
admet-547	194	14	from	from	ADP
admet-547	194	15	injection	injection	NOUN
admet-547	194	16	of	of	ADP
admet-547	194	17	gm6	gm6	PROPN
admet-547	194	18	for	for	ADP
admet-547	194	19	the	the	DET
admet-547	194	20	0.2	0.2	NUM
admet-547	194	21	mg	mg	PROPN
admet-547	194	22	/	/	SYM
admet-547	194	23	kg	kg	PROPN
admet-547	194	24	is	be	AUX
admet-547	194	25	1.36	1.36	NUM
admet-547	194	26	µm	µm	NOUN
admet-547	194	27	,	,	PUNCT
admet-547	194	28	for	for	ADP
admet-547	194	29	the	the	DET
admet-547	194	30	2.0	2.0	NUM
admet-547	194	31	mg	mg	NOUN
admet-547	194	32	/	/	SYM
admet-547	194	33	kg	kg	PROPN
admet-547	194	34	is	be	AUX
admet-547	194	35	12.52	12.52	NUM
admet-547	194	36	µm	µm	NOUN
admet-547	194	37	.	.	PUNCT
admet-547	195	1	the	the	DET
admet-547	195	2	net	net	ADJ
admet-547	195	3	increase	increase	NOUN
admet-547	195	4	of	of	ADP
admet-547	195	5	gm6	gm6	PROPN
admet-547	195	6	detected	detect	VERB
admet-547	195	7	is	be	AUX
admet-547	195	8	almost	almost	ADV
admet-547	195	9	proportional	proportional	ADJ
admet-547	195	10	.	.	PUNCT
admet-547	196	1	these	these	DET
admet-547	196	2	results	result	NOUN
admet-547	196	3	support	support	VERB
admet-547	196	4	the	the	DET
admet-547	196	5	prediction	prediction	NOUN
admet-547	196	6	that	that	PRON
admet-547	196	7	gm6	gm6	PROPN
admet-547	196	8	can	can	AUX
admet-547	196	9	partition	partition	VERB
admet-547	196	10	into	into	ADP
admet-547	196	11	tissues	tissue	NOUN
admet-547	196	12	based	base	VERB
admet-547	196	13	on	on	ADP
admet-547	196	14	its	its	PRON
admet-547	196	15	large	large	ADJ
admet-547	196	16	volume	volume	NOUN
admet-547	196	17	of	of	ADP
admet-547	196	18	distribution	distribution	NOUN
admet-547	196	19	and	and	CCONJ
admet-547	196	20	that	that	PRON
admet-547	196	21	has	have	VERB
admet-547	196	22	also	also	ADV
admet-547	196	23	a	a	DET
admet-547	196	24	good	good	ADJ
admet-547	196	25	brain	brain	NOUN
admet-547	196	26	penetration	penetration	NOUN
admet-547	196	27	[	[	X
admet-547	196	28	25	25	NUM
admet-547	196	29	]	]	PUNCT
admet-547	196	30	(	(	PUNCT
admet-547	196	31	brain	brain	NOUN
admet-547	196	32	to	to	ADP
admet-547	196	33	plasma	plasma	NOUN
admet-547	196	34	ratio	ratio	NOUN
admet-547	196	35	was	be	AUX
admet-547	196	36	estimated	estimate	VERB
admet-547	196	37	as	as	ADP
admet-547	196	38	1.65	1.65	NUM
admet-547	196	39	as	as	SCONJ
admet-547	196	40	indicated	indicate	VERB
admet-547	196	41	in	in	ADP
admet-547	196	42	table	table	NOUN
admet-547	196	43	2	2	NUM
admet-547	196	44	)	)	PUNCT
admet-547	196	45	.	.	PUNCT
admet-547	197	1	estimated	estimate	VERB
admet-547	197	2	pk	pk	NOUN
admet-547	197	3	profile	profile	NOUN
admet-547	197	4	of	of	ADP
admet-547	197	5	gm6	gm6	PROPN
admet-547	197	6	in	in	ADP
admet-547	197	7	order	order	NOUN
admet-547	197	8	to	to	PART
admet-547	197	9	estimate	estimate	VERB
admet-547	197	10	the	the	DET
admet-547	197	11	dose	dose	NOUN
admet-547	197	12	we	we	PRON
admet-547	197	13	have	have	AUX
admet-547	197	14	calculated	calculate	VERB
admet-547	197	15	the	the	DET
admet-547	197	16	minimum	minimum	ADJ
admet-547	197	17	effective	effective	ADJ
admet-547	197	18	concentration	concentration	NOUN
admet-547	197	19	of	of	ADP
admet-547	197	20	gm6	gm6	PROPN
admet-547	197	21	obtained	obtain	VERB
admet-547	197	22	from	from	ADP
admet-547	197	23	the	the	DET
admet-547	197	24	in	in	ADP
admet-547	197	25	vivo	vivo	NOUN
admet-547	197	26	mouse	mouse	NOUN
admet-547	197	27	experiment	experiment	NOUN
admet-547	197	28	described	describe	VERB
admet-547	197	29	in	in	ADP
admet-547	197	30	more	more	ADJ
admet-547	197	31	detail	detail	NOUN
admet-547	197	32	later	later	ADV
admet-547	197	33	.	.	PUNCT
admet-547	198	1	the	the	DET
admet-547	198	2	in	in	ADP
admet-547	198	3	vivo	vivo	NOUN
admet-547	198	4	results	result	NOUN
admet-547	198	5	showed	show	VERB
admet-547	198	6	that	that	SCONJ
admet-547	198	7	klara	klara	PROPN
admet-547	198	8	valko	valko	PROPN
admet-547	198	9	et	et	PROPN
admet-547	198	10	al	al	PROPN
admet-547	198	11	.	.	PROPN
admet-547	198	12	admet	admet	PROPN
admet-547	198	13	&	&	CCONJ
admet-547	198	14	dmpk	dmpk	PROPN
admet-547	198	15	6(2	6(2	NUM
admet-547	198	16	)	)	PUNCT
admet-547	198	17	(	(	PUNCT
admet-547	198	18	2018	2018	NUM
admet-547	198	19	)	)	PUNCT
admet-547	198	20	176	176	NUM
admet-547	198	21	-	-	SYM
admet-547	198	22	189	189	NUM
admet-547	198	23	186	186	NUM
admet-547	198	24	a	a	DET
admet-547	198	25	20	20	NUM
admet-547	198	26	mg	mg	NUM
admet-547	198	27	/	/	SYM
admet-547	198	28	kg	kg	PROPN
admet-547	198	29	dose	dose	NOUN
admet-547	198	30	of	of	ADP
admet-547	198	31	gm6	gm6	PROPN
admet-547	198	32	was	be	AUX
admet-547	198	33	efficacious	efficacious	ADJ
admet-547	198	34	in	in	ADP
admet-547	198	35	the	the	DET
admet-547	198	36	mouse	mouse	NOUN
admet-547	198	37	.	.	PUNCT
admet-547	199	1	using	use	VERB
admet-547	199	2	the	the	DET
admet-547	199	3	12.3	12.3	NUM
admet-547	199	4	factor	factor	NOUN
admet-547	199	5	from	from	ADP
admet-547	199	6	mouse	mouse	PROPN
admet-547	199	7	to	to	ADP
admet-547	199	8	human	human	NOUN
admet-547	199	9	according	accord	VERB
admet-547	199	10	to	to	ADP
admet-547	199	11	the	the	DET
admet-547	199	12	fda	fda	PROPN
admet-547	199	13	guidelines	guideline	NOUN
admet-547	199	14	[	[	X
admet-547	199	15	32	32	NUM
admet-547	199	16	]	]	PUNCT
admet-547	199	17	,	,	PUNCT
admet-547	199	18	the	the	DET
admet-547	199	19	dose	dose	NOUN
admet-547	199	20	was	be	AUX
admet-547	199	21	estimated	estimate	VERB
admet-547	199	22	to	to	PART
admet-547	199	23	be	be	AUX
admet-547	199	24	1.6	1.6	NUM
admet-547	199	25	mg	mg	NOUN
admet-547	199	26	/	/	SYM
admet-547	199	27	kg	kg	PROPN
admet-547	199	28	in	in	ADP
admet-547	199	29	human	human	NOUN
admet-547	199	30	.	.	PUNCT
admet-547	200	1	as	as	SCONJ
admet-547	200	2	the	the	DET
admet-547	200	3	drug	drug	NOUN
admet-547	200	4	efficiency	efficiency	NOUN
admet-547	200	5	of	of	ADP
admet-547	200	6	the	the	DET
admet-547	200	7	compound	compound	NOUN
admet-547	200	8	is	be	AUX
admet-547	200	9	around	around	ADV
admet-547	200	10	8	8	NUM
admet-547	200	11	%	%	NOUN
admet-547	200	12	it	it	PRON
admet-547	200	13	means	mean	VERB
admet-547	200	14	that	that	SCONJ
admet-547	200	15	only	only	ADV
admet-547	200	16	8	8	NUM
admet-547	200	17	%	%	NOUN
admet-547	200	18	of	of	ADP
admet-547	200	19	the	the	DET
admet-547	200	20	administered	administer	VERB
admet-547	200	21	dose	dose	NOUN
admet-547	200	22	is	be	AUX
admet-547	200	23	available	available	ADJ
admet-547	200	24	as	as	ADP
admet-547	200	25	free	free	ADJ
admet-547	200	26	.	.	PUNCT
admet-547	201	1	that	that	PRON
admet-547	201	2	is	be	AUX
admet-547	201	3	equivalent	equivalent	ADJ
admet-547	201	4	to	to	ADP
admet-547	201	5	0.08·1.6	0.08·1.6	NUM
admet-547	201	6	mg	mg	PROPN
admet-547	201	7	/	/	SYM
admet-547	201	8	kg	kg	PROPN
admet-547	201	9	,	,	PUNCT
admet-547	201	10	which	which	PRON
admet-547	201	11	is	be	AUX
admet-547	201	12	0.13	0.13	NUM
admet-547	201	13	mg	mg	PROPN
admet-547	201	14	/	/	SYM
admet-547	201	15	kg	kg	NOUN
admet-547	201	16	which	which	PRON
admet-547	201	17	equals	equal	VERB
admet-547	201	18	1.3·10	1.3·10	NOUN
admet-547	201	19	-4	-4	NOUN
admet-547	201	20	g	g	NOUN
admet-547	201	21	/	/	SYM
admet-547	201	22	kg	kg	PROPN
admet-547	201	23	.	.	PUNCT
admet-547	202	1	taking	take	VERB
admet-547	202	2	into	into	ADP
admet-547	202	3	account	account	NOUN
admet-547	202	4	the	the	DET
admet-547	202	5	799	799	NUM
admet-547	202	6	da	da	NOUN
admet-547	202	7	molecular	molecular	ADJ
admet-547	202	8	weight	weight	NOUN
admet-547	202	9	of	of	ADP
admet-547	202	10	gm6	gm6	PROPN
admet-547	202	11	it	it	PRON
admet-547	202	12	is	be	AUX
admet-547	202	13	equivalent	equivalent	ADJ
admet-547	202	14	to	to	ADP
admet-547	202	15	a	a	DET
admet-547	202	16	1.6·10	1.6·10	NUM
admet-547	202	17	-7	-7	NOUN
admet-547	202	18	m	m	NOUN
admet-547	202	19	concentration	concentration	NOUN
admet-547	202	20	.	.	PUNCT
admet-547	203	1	it	it	PRON
admet-547	203	2	means	mean	VERB
admet-547	203	3	that	that	SCONJ
admet-547	203	4	the	the	DET
admet-547	203	5	pic50	pic50	NOUN
admet-547	203	6	or	or	CCONJ
admet-547	203	7	in	in	ADP
admet-547	203	8	other	other	ADJ
admet-547	203	9	words	word	NOUN
admet-547	203	10	the	the	DET
admet-547	203	11	minimum	minimum	ADJ
admet-547	203	12	effective	effective	ADJ
admet-547	203	13	concentration	concentration	NOUN
admet-547	203	14	(	(	PUNCT
admet-547	203	15	mec	mec	NOUN
admet-547	203	16	)	)	PUNCT
admet-547	203	17	of	of	ADP
admet-547	203	18	the	the	DET
admet-547	203	19	peptide	peptide	NOUN
admet-547	203	20	is	be	AUX
admet-547	203	21	estimated	estimate	VERB
admet-547	203	22	to	to	PART
admet-547	203	23	be	be	AUX
admet-547	203	24	around	around	ADP
admet-547	203	25	1.6·10	1.6·10	NUM
admet-547	203	26	-7	-7	PUNCT
admet-547	203	27	m.	m.	NOUN
admet-547	203	28	the	the	DET
admet-547	203	29	dose	dose	NOUN
admet-547	203	30	can	can	AUX
admet-547	203	31	be	be	AUX
admet-547	203	32	estimated	estimate	VERB
admet-547	203	33	from	from	ADP
admet-547	203	34	the	the	DET
admet-547	203	35	pic50	pic50	NOUN
admet-547	203	36	and	and	CCONJ
admet-547	203	37	the	the	DET
admet-547	203	38	drug	drug	NOUN
admet-547	203	39	efficiency	efficiency	NOUN
admet-547	203	40	as	as	SCONJ
admet-547	203	41	it	it	PRON
admet-547	203	42	has	have	AUX
admet-547	203	43	been	be	AUX
admet-547	203	44	described	describe	VERB
admet-547	203	45	earlier	early	ADV
admet-547	203	46	[	[	X
admet-547	203	47	21	21	NUM
admet-547	203	48	]	]	PUNCT
admet-547	203	49	.	.	PUNCT
admet-547	204	1	this	this	DET
admet-547	204	2	dose	dose	NOUN
admet-547	204	3	estimation	estimation	NOUN
admet-547	204	4	refers	refer	VERB
admet-547	204	5	to	to	ADP
admet-547	204	6	a	a	DET
admet-547	204	7	steady	steady	ADJ
admet-547	204	8	state	state	NOUN
admet-547	204	9	and	and	CCONJ
admet-547	204	10	does	do	AUX
admet-547	204	11	not	not	PART
admet-547	204	12	take	take	VERB
admet-547	204	13	into	into	ADP
admet-547	204	14	account	account	NOUN
admet-547	204	15	the	the	DET
admet-547	204	16	elimination	elimination	NOUN
admet-547	204	17	rate	rate	NOUN
admet-547	204	18	and	and	CCONJ
admet-547	204	19	dosing	dosing	NOUN
admet-547	204	20	frequency	frequency	NOUN
admet-547	204	21	.	.	PUNCT
admet-547	205	1	figure	figure	NOUN
admet-547	205	2	4	4	NUM
admet-547	205	3	.	.	PUNCT
admet-547	206	1	detection	detection	NOUN
admet-547	206	2	gm6	gm6	PROPN
admet-547	206	3	in	in	ADP
admet-547	206	4	mouse	mouse	NOUN
admet-547	206	5	brain	brain	NOUN
admet-547	206	6	after	after	ADP
admet-547	206	7	four	four	NUM
admet-547	206	8	hours	hour	NOUN
admet-547	206	9	of	of	ADP
admet-547	206	10	the	the	DET
admet-547	206	11	treatment	treatment	NOUN
admet-547	206	12	by	by	ADP
admet-547	206	13	elisa	elisa	NOUN
admet-547	206	14	analysis	analysis	NOUN
admet-547	206	15	.	.	PUNCT
admet-547	207	1	using	use	VERB
admet-547	207	2	the	the	DET
admet-547	207	3	one	one	NUM
admet-547	207	4	-	-	PUNCT
admet-547	207	5	compartment	compartment	NOUN
admet-547	207	6	model	model	NOUN
admet-547	207	7	[	[	X
admet-547	207	8	33	33	NUM
admet-547	207	9	]	]	PUNCT
admet-547	207	10	and	and	CCONJ
admet-547	207	11	a	a	DET
admet-547	207	12	132.5	132.5	NUM
admet-547	207	13	mg	mg	NOUN
admet-547	207	14	dose	dose	NOUN
admet-547	207	15	for	for	ADP
admet-547	207	16	an	an	DET
admet-547	207	17	average	average	ADJ
admet-547	207	18	70	70	NUM
admet-547	207	19	kg	kg	NOUN
admet-547	207	20	human	human	NOUN
admet-547	207	21	,	,	PUNCT
admet-547	207	22	a	a	DET
admet-547	207	23	hypothetical	hypothetical	ADJ
admet-547	207	24	pk	pk	NOUN
admet-547	207	25	profile	profile	NOUN
admet-547	207	26	can	can	AUX
admet-547	207	27	be	be	AUX
admet-547	207	28	calculated	calculate	VERB
admet-547	207	29	using	use	VERB
admet-547	207	30	the	the	DET
admet-547	207	31	parameters	parameter	NOUN
admet-547	207	32	listed	list	VERB
admet-547	207	33	in	in	ADP
admet-547	207	34	table	table	NOUN
admet-547	207	35	3	3	NUM
admet-547	207	36	based	base	VERB
admet-547	207	37	on	on	ADP
admet-547	207	38	equation	equation	NOUN
admet-547	207	39	(	(	PUNCT
admet-547	207	40	5	5	NUM
admet-547	207	41	)	)	PUNCT
admet-547	207	42	.	.	PUNCT
admet-547	208	1			NOUN
admet-547	208	2			NOUN
admet-547	209	1			PROPN
admet-547	209	2	24	24	NUM
admet-547	209	3	mec	mec	PROPN
admet-547	209	4	exp	exp	NOUN
admet-547	209	5	1	1	NUM
admet-547	209	6	dose	dose	PROPN
admet-547	209	7	(	(	PUNCT
admet-547	209	8	mg	mg	PROPN
admet-547	209	9	/	/	SYM
admet-547	209	10	kg	kg	PROPN
admet-547	209	11	/	/	SYM
admet-547	209	12	day	day	NOUN
admet-547	209	13	)	)	PUNCT
admet-547	209	14	dss	dss	NOUN
admet-547	209	15	elv	elv	PROPN
admet-547	210	1	k	k	PROPN
admet-547	210	2	f	f	PROPN
admet-547	210	3			NOUN
admet-547	210	4			VERB
admet-547	210	5			VERB
admet-547	210	6			NOUN
admet-547	210	7			NUM
admet-547	210	8	(	(	PUNCT
admet-547	210	9	5	5	NUM
admet-547	210	10	)	)	PUNCT
admet-547	210	11	where	where	SCONJ
admet-547	210	12	τ	τ	PROPN
admet-547	210	13	is	be	AUX
admet-547	210	14	the	the	DET
admet-547	210	15	dosing	dosing	ADJ
admet-547	210	16	interval	interval	NOUN
admet-547	210	17	,	,	PUNCT
admet-547	210	18	kel	kel	PROPN
admet-547	210	19	is	be	AUX
admet-547	210	20	the	the	DET
admet-547	210	21	elimination	elimination	NOUN
admet-547	210	22	rate	rate	NOUN
admet-547	210	23	calculated	calculate	VERB
admet-547	210	24	from	from	ADP
admet-547	210	25	the	the	DET
admet-547	210	26	in	in	ADV
admet-547	210	27	vitro	vitro	X
admet-547	210	28	clearance	clearance	NOUN
admet-547	210	29	(	(	PUNCT
admet-547	210	30	equation	equation	NOUN
admet-547	210	31	(	(	PUNCT
admet-547	210	32	4	4	NUM
admet-547	210	33	)	)	PUNCT
admet-547	210	34	)	)	PUNCT
admet-547	210	35	,	,	PUNCT
admet-547	210	36	vdss	vdss	ADV
admet-547	210	37	is	be	AUX
admet-547	210	38	the	the	DET
admet-547	210	39	steady	steady	ADJ
admet-547	210	40	-	-	PUNCT
admet-547	210	41	state	state	NOUN
admet-547	210	42	volume	volume	NOUN
admet-547	210	43	of	of	ADP
admet-547	210	44	distribution	distribution	NOUN
admet-547	210	45	,	,	PUNCT
admet-547	210	46	f	f	PROPN
admet-547	210	47	is	be	AUX
admet-547	210	48	the	the	DET
admet-547	210	49	bioavailability	bioavailability	NOUN
admet-547	210	50	considered	consider	VERB
admet-547	210	51	1	1	NUM
admet-547	210	52	and	and	CCONJ
admet-547	210	53	the	the	DET
admet-547	210	54	absorption	absorption	NOUN
admet-547	210	55	rate	rate	NOUN
admet-547	210	56	considered	consider	VERB
admet-547	210	57	fast	fast	ADV
admet-547	210	58	after	after	ADP
admet-547	210	59	iv	iv	NUM
admet-547	210	60	administration	administration	NOUN
admet-547	210	61	.	.	PUNCT
admet-547	211	1	the	the	DET
admet-547	211	2	intrinsic	intrinsic	ADJ
admet-547	211	3	clearance	clearance	NOUN
admet-547	211	4	(	(	PUNCT
admet-547	211	5	clint	clint	NOUN
admet-547	211	6	)	)	PUNCT
admet-547	211	7	for	for	ADP
admet-547	211	8	gm6	gm6	PROPN
admet-547	211	9	in	in	ADP
admet-547	211	10	human	human	ADJ
admet-547	211	11	microsome	microsome	ADJ
admet-547	211	12	assays	assay	NOUN
admet-547	211	13	was	be	AUX
admet-547	211	14	determined	determine	VERB
admet-547	211	15	to	to	PART
admet-547	211	16	be	be	AUX
admet-547	211	17	<	<	X
admet-547	211	18	115.5	115.5	NUM
admet-547	211	19	µg	µg	NOUN
admet-547	211	20	/	/	SYM
admet-547	211	21	ml	ml	NOUN
admet-547	211	22	/	/	SYM
admet-547	211	23	min	min	NOUN
admet-547	211	24	/	/	SYM
admet-547	211	25	mg	mg	PROPN
admet-547	211	26	.	.	PUNCT
admet-547	212	1	to	to	PART
admet-547	212	2	convert	convert	VERB
admet-547	212	3	the	the	DET
admet-547	212	4	clint	clint	NOUN
admet-547	212	5	data	datum	NOUN
admet-547	212	6	from	from	ADP
admet-547	212	7	115	115	NUM
admet-547	212	8	ug	ug	ADP
admet-547	212	9	/	/	SYM
admet-547	212	10	min	min	PROPN
admet-547	212	11	/	/	SYM
admet-547	212	12	mg	mg	PROPN
admet-547	212	13	human	human	ADJ
admet-547	212	14	liver	liver	NOUN
admet-547	212	15	microsomes	microsome	NOUN
admet-547	212	16	to	to	PART
admet-547	212	17	ml	ml	NOUN
admet-547	212	18	/	/	SYM
admet-547	212	19	min	min	NOUN
admet-547	212	20	/	/	SYM
admet-547	212	21	kg	kg	NOUN
admet-547	212	22	we	we	PRON
admet-547	212	23	used	use	VERB
admet-547	212	24	the	the	DET
admet-547	212	25	human	human	ADJ
admet-547	212	26	scaling	scale	VERB
admet-547	212	27	factor	factor	NOUN
admet-547	212	28	of	of	ADP
admet-547	212	29	mg	mg	PROPN
admet-547	212	30	protein	protein	NOUN
admet-547	212	31	in	in	ADP
admet-547	212	32	liver	liver	NOUN
admet-547	212	33	:	:	PUNCT
admet-547	212	34	115	115	NUM
admet-547	212	35	x	x	SYM
admet-547	212	36	39.7	39.7	NUM
admet-547	212	37	=	=	SYM
admet-547	212	38	4565.5	4565.5	NUM
admet-547	212	39	µg	µg	NOUN
admet-547	212	40	/	/	SYM
admet-547	212	41	min	min	NOUN
admet-547	212	42	/	/	SYM
admet-547	212	43	g	g	NOUN
admet-547	212	44	liver	liver	NOUN
admet-547	212	45	which	which	PRON
admet-547	212	46	is	be	AUX
admet-547	212	47	equivalent	equivalent	ADJ
admet-547	212	48	to	to	ADP
admet-547	212	49	4565/1000	4565/1000	NUM
admet-547	212	50	=	=	SYM
admet-547	212	51	4.565	4.565	NUM
admet-547	212	52	ml	ml	NOUN
admet-547	212	53	/	/	SYM
admet-547	212	54	min	min	NOUN
admet-547	212	55	/	/	SYM
admet-547	212	56	g	g	NOUN
admet-547	212	57	liver	liver	NOUN
admet-547	212	58	.	.	PUNCT
admet-547	213	1	this	this	DET
admet-547	213	2	value	value	NOUN
admet-547	213	3	should	should	AUX
admet-547	213	4	go	go	VERB
admet-547	213	5	to	to	ADP
admet-547	213	6	the	the	DET
admet-547	213	7	well	well	ADV
admet-547	213	8	-	-	PUNCT
admet-547	213	9	stirred	stir	VERB
admet-547	213	10	model	model	NOUN
admet-547	213	11	(	(	PUNCT
admet-547	213	12	wsm	wsm	NOUN
admet-547	213	13	)	)	PUNCT
admet-547	213	14	to	to	PART
admet-547	213	15	estimate	estimate	VERB
admet-547	213	16	the	the	DET
admet-547	213	17	human	human	ADJ
admet-547	213	18	whole	whole	ADJ
admet-547	213	19	-	-	PUNCT
admet-547	213	20	body	body	NOUN
admet-547	213	21	clearance	clearance	NOUN
admet-547	213	22	(	(	PUNCT
admet-547	213	23	kel	kel	NOUN
admet-547	213	24	)	)	PUNCT
admet-547	213	25	.	.	PUNCT
admet-547	214	1	using	use	VERB
admet-547	214	2	the	the	DET
admet-547	214	3	wsm	wsm	NOUN
admet-547	214	4	model	model	NOUN
admet-547	214	5	it	it	PRON
admet-547	214	6	is	be	AUX
admet-547	214	7	equivalent	equivalent	ADJ
admet-547	214	8	to	to	ADP
admet-547	214	9	15.5	15.5	NUM
admet-547	214	10	ml	ml	NOUN
admet-547	214	11	/	/	SYM
admet-547	214	12	min	min	NOUN
admet-547	214	13	/	/	SYM
admet-547	214	14	kg	kg	X
admet-547	214	15	(	(	PUNCT
admet-547	214	16	which	which	PRON
admet-547	214	17	is	be	AUX
admet-547	214	18	equivalent	equivalent	ADJ
admet-547	214	19	to	to	ADP
admet-547	214	20	86	86	NUM
admet-547	214	21	%	%	NOUN
admet-547	214	22	of	of	ADP
admet-547	214	23	the	the	DET
admet-547	214	24	liver	liver	NOUN
admet-547	214	25	blood	blood	NOUN
admet-547	214	26	flow	flow	NOUN
admet-547	214	27	)	)	PUNCT
admet-547	214	28	as	as	ADP
admet-547	214	29	the	the	DET
admet-547	214	30	clearance	clearance	NOUN
admet-547	214	31	of	of	ADP
admet-547	214	32	gm6	gm6	PROPN
admet-547	214	33	which	which	PRON
admet-547	214	34	is	be	AUX
admet-547	214	35	relatively	relatively	ADV
admet-547	214	36	rapid	rapid	ADJ
admet-547	214	37	.	.	PUNCT
admet-547	215	1	it	it	PRON
admet-547	215	2	is	be	AUX
admet-547	215	3	supposed	suppose	VERB
admet-547	215	4	that	that	SCONJ
admet-547	215	5	gm6	gm6	PRON
admet-547	215	6	being	be	AUX
admet-547	215	7	an	an	DET
admet-547	215	8	endogenous	endogenous	ADJ
admet-547	215	9	neuropeptide	neuropeptide	NOUN
admet-547	215	10	with	with	ADP
admet-547	215	11	two	two	NUM
admet-547	215	12	positive	positive	ADJ
admet-547	215	13	charges	charge	NOUN
admet-547	215	14	and	and	CCONJ
admet-547	215	15	relatively	relatively	ADV
admet-547	215	16	small	small	ADJ
admet-547	215	17	(	(	PUNCT
admet-547	215	18	mw=799	mw=799	PROPN
admet-547	215	19	)	)	PUNCT
admet-547	215	20	the	the	DET
admet-547	215	21	liver	liver	NOUN
admet-547	215	22	microsomes	microsome	NOUN
admet-547	215	23	provide	provide	VERB
admet-547	215	24	the	the	DET
admet-547	215	25	major	major	ADJ
admet-547	215	26	elimination	elimination	NOUN
admet-547	215	27	route	route	NOUN
admet-547	215	28	.	.	PUNCT
admet-547	216	1	it	it	PRON
admet-547	216	2	is	be	AUX
admet-547	216	3	also	also	ADV
admet-547	216	4	important	important	ADJ
admet-547	216	5	to	to	PART
admet-547	216	6	note	note	VERB
admet-547	216	7	that	that	SCONJ
admet-547	216	8	gm6	gm6	PROPN
admet-547	216	9	has	have	VERB
admet-547	216	10	a	a	DET
admet-547	216	11	large	large	ADJ
admet-547	216	12	estimated	estimate	VERB
admet-547	216	13	volume	volume	NOUN
admet-547	216	14	of	of	ADP
admet-547	216	15	distribution	distribution	NOUN
admet-547	216	16	(	(	PUNCT
admet-547	216	17	over	over	ADP
admet-547	216	18	7.8	7.8	NUM
admet-547	216	19	l	l	NOUN
admet-547	216	20	/	/	SYM
admet-547	216	21	kg	kg	NOUN
admet-547	216	22	)	)	PUNCT
admet-547	216	23	unlike	unlike	ADP
admet-547	216	24	other	other	ADJ
admet-547	216	25	peptides	peptide	NOUN
admet-547	216	26	and	and	CCONJ
admet-547	216	27	it	it	PRON
admet-547	216	28	binds	bind	VERB
admet-547	216	29	to	to	ADP
admet-547	216	30	phospholipid	phospholipid	NOUN
admet-547	216	31	very	very	ADV
admet-547	216	32	strongly	strongly	ADV
admet-547	216	33	(	(	PUNCT
admet-547	216	34	chi	chi	PROPN
admet-547	216	35	iam	iam	PROPN
admet-547	216	36	value	value	NOUN
admet-547	216	37	is	be	AUX
admet-547	216	38	above	above	ADP
admet-547	216	39	42	42	NUM
admet-547	216	40	)	)	PUNCT
admet-547	216	41	.	.	PUNCT
admet-547	217	1	in	in	ADP
admet-547	217	2	a	a	DET
admet-547	217	3	recent	recent	ADJ
admet-547	217	4	review	review	NOUN
admet-547	217	5	[	[	X
admet-547	217	6	34	34	NUM
admet-547	217	7	]	]	PUNCT
admet-547	217	8	about	about	ADP
admet-547	217	9	the	the	DET
admet-547	217	10	pharmacokinetic	pharmacokinetic	ADJ
admet-547	217	11	studies	study	NOUN
admet-547	217	12	of	of	ADP
admet-547	217	13	protein	protein	NOUN
admet-547	217	14	,	,	PUNCT
admet-547	217	15	drugs	drug	NOUN
admet-547	217	16	raise	raise	VERB
admet-547	217	17	the	the	DET
admet-547	217	18	question	question	NOUN
admet-547	217	19	whether	whether	SCONJ
admet-547	217	20	the	the	DET
admet-547	217	21	blood	blood	NOUN
admet-547	217	22	concentration	concentration	NOUN
admet-547	217	23	is	be	AUX
admet-547	217	24	relevant	relevant	ADJ
admet-547	217	25	or	or	CCONJ
admet-547	217	26	not	not	PART
admet-547	217	27	to	to	ADP
admet-547	217	28	pharmacodynamics	pharmacodynamic	NOUN
admet-547	217	29	with	with	ADP
admet-547	217	30	the	the	DET
admet-547	217	31	emphasis	emphasis	NOUN
admet-547	217	32	on	on	ADP
admet-547	217	33	the	the	DET
admet-547	217	34	tissue	tissue	NOUN
admet-547	217	35	concentration	concentration	NOUN
admet-547	217	36	.	.	PUNCT
admet-547	218	1	admet	admet	PROPN
admet-547	218	2	&	&	CCONJ
admet-547	218	3	dmpk	dmpk	PROPN
admet-547	218	4	6(2	6(2	NUM
admet-547	218	5	)	)	PUNCT
admet-547	218	6	(	(	PUNCT
admet-547	218	7	2018	2018	NUM
admet-547	218	8	)	)	PUNCT
admet-547	218	9	176	176	NUM
admet-547	218	10	-	-	SYM
admet-547	218	11	189	189	NUM
admet-547	218	12	in	in	ADP
admet-547	218	13	vitro	vitro	X
admet-547	218	14	and	and	CCONJ
admet-547	218	15	in	in	ADP
admet-547	218	16	vivo	vivo	ADJ
admet-547	218	17	characterization	characterization	NOUN
admet-547	218	18	of	of	ADP
admet-547	218	19	gm6	gm6	PROPN
admet-547	218	20	doi	doi	NOUN
admet-547	218	21	:	:	PUNCT
admet-547	218	22	10.5599	10.5599	NUM
admet-547	218	23	/	/	SYM
admet-547	218	24	admet.547	admet.547	ADJ
admet-547	218	25	187	187	NUM
admet-547	218	26	table	table	NOUN
admet-547	218	27	3	3	NUM
admet-547	218	28	.	.	PUNCT
admet-547	219	1	the	the	DET
admet-547	219	2	parameters	parameter	NOUN
admet-547	219	3	used	use	VERB
admet-547	219	4	in	in	ADP
admet-547	219	5	estimating	estimate	VERB
admet-547	219	6	the	the	DET
admet-547	219	7	pk	pk	NOUN
admet-547	219	8	profile	profile	NOUN
admet-547	219	9	of	of	ADP
admet-547	219	10	gm6	gm6	PROPN
admet-547	219	11	in	in	ADP
admet-547	219	12	human	human	NOUN
admet-547	219	13	after	after	ADP
admet-547	219	14	132	132	NUM
admet-547	219	15	mg	mg	NUM
admet-547	219	16	iv	iv	NUM
admet-547	219	17	dose	dose	PROPN
admet-547	219	18	.	.	PUNCT
admet-547	220	1	body	body	NOUN
admet-547	220	2	weight	weight	NOUN
admet-547	220	3	(	(	PUNCT
admet-547	220	4	kg	kg	NOUN
admet-547	220	5	)	)	PUNCT
admet-547	220	6	70	70	NUM
admet-547	220	7	dosing	dose	VERB
admet-547	220	8	interval	interval	NOUN
admet-547	220	9	(	(	PUNCT
admet-547	220	10	τ	τ	NOUN
admet-547	220	11	)	)	PUNCT
admet-547	220	12	1	1	NUM
admet-547	220	13	dose	dose	NOUN
admet-547	220	14	(	(	PUNCT
admet-547	220	15	mg	mg	PROPN
admet-547	220	16	/	/	SYM
admet-547	220	17	day	day	NOUN
admet-547	220	18	)	)	PUNCT
admet-547	220	19	132.5	132.5	NUM
admet-547	220	20	dose	dose	NOUN
admet-547	220	21	(	(	PUNCT
admet-547	220	22	mg	mg	PROPN
admet-547	220	23	/	/	SYM
admet-547	220	24	kg	kg	NOUN
admet-547	220	25	)	)	PUNCT
admet-547	220	26	1.89	1.89	NUM
admet-547	220	27	vd	vd	NOUN
admet-547	220	28	(	(	PUNCT
admet-547	220	29	l	l	NOUN
admet-547	220	30	/	/	SYM
admet-547	220	31	kg	kg	NOUN
admet-547	220	32	)	)	PUNCT
admet-547	220	33	7.8	7.8	NUM
admet-547	220	34	cl	cl	NOUN
admet-547	220	35	(	(	PUNCT
admet-547	220	36	ml	ml	NOUN
admet-547	220	37	/	/	SYM
admet-547	220	38	min	min	NOUN
admet-547	220	39	/	/	SYM
admet-547	220	40	kg	kg	NOUN
admet-547	220	41	)	)	PUNCT
admet-547	220	42	15.5	15.5	NUM
admet-547	220	43	cl	cl	NOUN
admet-547	220	44	(	(	PUNCT
admet-547	220	45	l	l	NOUN
admet-547	220	46	/	/	SYM
admet-547	220	47	h	h	NOUN
admet-547	220	48	/	/	SYM
admet-547	220	49	kg	kg	NOUN
admet-547	220	50	)	)	PUNCT
admet-547	220	51	)	)	PUNCT
admet-547	221	1	0.93	0.93	NUM
admet-547	221	2	cl	cl	NOUN
admet-547	221	3	(	(	PUNCT
admet-547	221	4	ml	ml	NOUN
admet-547	221	5	/	/	SYM
admet-547	221	6	min	min	NOUN
admet-547	221	7	)	)	PUNCT
admet-547	221	8	1085.0	1085.0	NUM
admet-547	221	9	cl	cl	NOUN
admet-547	221	10	/	/	SYM
admet-547	221	11	f	f	NOUN
admet-547	221	12	(	(	PUNCT
admet-547	221	13	ml	ml	PROPN
admet-547	221	14	/	/	SYM
admet-547	221	15	min	min	NOUN
admet-547	221	16	)	)	PUNCT
admet-547	221	17	1085.0	1085.0	NUM
admet-547	221	18	cl	cl	NOUN
admet-547	221	19	/	/	SYM
admet-547	221	20	f	f	NOUN
admet-547	221	21	(	(	PUNCT
admet-547	221	22	l	l	NOUN
admet-547	221	23	/	/	SYM
admet-547	221	24	min	min	NOUN
admet-547	221	25	)	)	PUNCT
admet-547	221	26	1.085	1.085	NUM
admet-547	221	27	fu	fu	NOUN
admet-547	221	28	blood	blood	NOUN
admet-547	221	29	(	(	PUNCT
admet-547	221	30	%	%	NOUN
admet-547	221	31	)	)	PUNCT
admet-547	221	32	68.60	68.60	NUM
admet-547	221	33	tmax	tmax	PROPN
admet-547	221	34	(	(	PUNCT
admet-547	221	35	h	h	NOUN
admet-547	221	36	)	)	PUNCT
admet-547	221	37	0.8	0.8	NUM
admet-547	221	38	cmax	cmax	NOUN
admet-547	221	39	(	(	PUNCT
admet-547	221	40	ng	ng	NOUN
admet-547	221	41	/	/	SYM
admet-547	221	42	ml	ml	NOUN
admet-547	221	43	)	)	PUNCT
admet-547	221	44	222	222	NUM
admet-547	221	45	ke	ke	NOUN
admet-547	221	46	(	(	PUNCT
admet-547	221	47	1	1	NUM
admet-547	221	48	/	/	SYM
admet-547	221	49	h	h	NOUN
admet-547	221	50	)	)	PUNCT
admet-547	221	51	0.12	0.12	NUM
admet-547	221	52	t1/2	t1/2	NOUN
admet-547	221	53	(	(	PUNCT
admet-547	221	54	h	h	NOUN
admet-547	221	55	)	)	PUNCT
admet-547	221	56	5.8	5.8	NUM
admet-547	221	57	auc	auc	NOUN
admet-547	221	58	(	(	PUNCT
admet-547	221	59	ng	ng	PROPN
admet-547	221	60	/	/	SYM
admet-547	221	61	ml*h	ml*h	NUM
admet-547	221	62	)	)	PUNCT
admet-547	221	63	2037	2037	NUM
admet-547	221	64	vdu	vdu	PROPN
admet-547	221	65	(	(	PUNCT
admet-547	221	66	l	l	NOUN
admet-547	221	67	/	/	SYM
admet-547	221	68	kg	kg	NOUN
admet-547	221	69	)	)	PUNCT
admet-547	221	70	11.4	11.4	NUM
admet-547	221	71	drugeff	drugeff	NOUN
admet-547	221	72	max	max	PROPN
admet-547	221	73	(	(	PUNCT
admet-547	221	74	%	%	INTJ
admet-547	221	75	)	)	PUNCT
admet-547	221	76	8.8	8.8	NUM
admet-547	221	77	drugeff	drugeff	NOUN
admet-547	221	78	blood	blood	NOUN
admet-547	221	79	cmax	cmax	NOUN
admet-547	221	80	u	u	NOUN
admet-547	221	81	(	(	PUNCT
admet-547	221	82	%	%	INTJ
admet-547	221	83	)	)	PUNCT
admet-547	221	84	8.03	8.03	NUM
admet-547	221	85	compound	compound	NOUN
admet-547	221	86	information	information	NOUN
admet-547	221	87	gm6	gm6	PROPN
admet-547	221	88	molecular	molecular	ADJ
admet-547	221	89	weight	weight	NOUN
admet-547	221	90	799	799	NUM
admet-547	221	91	pxc50	pxc50	NOUN
admet-547	221	92	(	(	PUNCT
admet-547	221	93	based	base	VERB
admet-547	221	94	on	on	ADP
admet-547	221	95	in	in	ADP
admet-547	221	96	vivo	vivo	ADJ
admet-547	221	97	efficacious	efficacious	ADJ
admet-547	221	98	concentration	concentration	NOUN
admet-547	221	99	)	)	PUNCT
admet-547	221	100	7	7	NUM
admet-547	221	101	conc	conc	NOUN
admet-547	221	102	(	(	PUNCT
admet-547	221	103	nm	nm	NOUN
admet-547	221	104	)	)	PUNCT
admet-547	221	105	100.00	100.00	NUM
admet-547	221	106	total	total	NOUN
admet-547	221	107	conc	conc	NOUN
admet-547	221	108	(	(	PUNCT
admet-547	221	109	nm	nm	NOUN
admet-547	221	110	)	)	PUNCT
admet-547	221	111	145.77	145.77	NUM
admet-547	221	112	conc	conc	NOUN
admet-547	221	113	(	(	PUNCT
admet-547	221	114	ng	ng	NOUN
admet-547	221	115	/	/	SYM
admet-547	221	116	ml	ml	NOUN
admet-547	221	117	)	)	PUNCT
admet-547	221	118	79.90	79.90	NUM
admet-547	221	119	total	total	NOUN
admet-547	221	120	conc	conc	NOUN
admet-547	221	121	(	(	PUNCT
admet-547	221	122	ng	ng	NOUN
admet-547	221	123	/	/	SYM
admet-547	221	124	ml	ml	NOUN
admet-547	221	125	)	)	PUNCT
admet-547	221	126	116.47	116.47	NUM
admet-547	221	127	equation	equation	NOUN
admet-547	221	128	5	5	NUM
admet-547	221	129	describes	describe	VERB
admet-547	221	130	the	the	DET
admet-547	221	131	hypothetical	hypothetical	ADJ
admet-547	221	132	plasma	plasma	NOUN
admet-547	221	133	concentration	concentration	NOUN
admet-547	221	134	vs	vs	ADP
admet-547	221	135	time	time	NOUN
admet-547	221	136	profile	profile	NOUN
admet-547	221	137	of	of	ADP
admet-547	221	138	drugs	drug	NOUN
admet-547	221	139	.	.	PUNCT
admet-547	222	1	as	as	SCONJ
admet-547	222	2	gm6	gm6	PROPN
admet-547	222	3	has	have	VERB
admet-547	222	4	a	a	DET
admet-547	222	5	short	short	ADJ
admet-547	222	6	half	half	ADJ
admet-547	222	7	-	-	PUNCT
admet-547	222	8	life	life	NOUN
admet-547	222	9	in	in	ADP
admet-547	222	10	plasma	plasma	NOUN
admet-547	222	11	but	but	CCONJ
admet-547	222	12	it	it	PRON
admet-547	222	13	was	be	AUX
admet-547	222	14	detected	detect	VERB
admet-547	222	15	in	in	ADP
admet-547	222	16	brain	brain	NOUN
admet-547	222	17	tissue	tissue	NOUN
admet-547	222	18	after	after	ADP
admet-547	222	19	4	4	NUM
admet-547	222	20	hours	hour	NOUN
admet-547	222	21	,	,	PUNCT
admet-547	222	22	instead	instead	ADV
admet-547	222	23	of	of	ADP
admet-547	222	24	the	the	DET
admet-547	222	25	total	total	ADJ
admet-547	222	26	plasma	plasma	NOUN
admet-547	222	27	concentration	concentration	NOUN
admet-547	222	28	vs	vs	ADP
admet-547	222	29	time	time	NOUN
admet-547	222	30	profile	profile	NOUN
admet-547	222	31	the	the	DET
admet-547	222	32	free	free	ADJ
admet-547	222	33	concentration	concentration	NOUN
admet-547	222	34	-	-	PUNCT
admet-547	222	35	time	time	NOUN
admet-547	222	36	profile	profile	NOUN
admet-547	222	37	was	be	AUX
admet-547	222	38	calculated	calculate	VERB
admet-547	222	39	that	that	PRON
admet-547	222	40	is	be	AUX
admet-547	222	41	referred	refer	VERB
admet-547	222	42	to	to	ADP
admet-547	222	43	tissues	tissue	NOUN
admet-547	222	44	.	.	PUNCT
admet-547	223	1	the	the	DET
admet-547	223	2	estimated	estimate	VERB
admet-547	223	3	half	half	ADJ
admet-547	223	4	-	-	PUNCT
admet-547	223	5	life	life	NOUN
admet-547	223	6	in	in	ADP
admet-547	223	7	tissues	tissue	NOUN
admet-547	223	8	including	include	VERB
admet-547	223	9	only	only	ADV
admet-547	223	10	the	the	DET
admet-547	223	11	microsomal	microsomal	ADJ
admet-547	223	12	clearance	clearance	NOUN
admet-547	223	13	was	be	AUX
admet-547	223	14	calculated	calculate	VERB
admet-547	223	15	as	as	ADP
admet-547	223	16	5.8	5.8	NUM
admet-547	223	17	h.	h.	NOUN
admet-547	223	18	this	this	DET
admet-547	223	19	pk	pk	NOUN
admet-547	223	20	profile	profile	NOUN
admet-547	223	21	would	would	AUX
admet-547	223	22	have	have	AUX
admet-547	223	23	been	be	AUX
admet-547	223	24	very	very	ADV
admet-547	223	25	difficult	difficult	ADJ
admet-547	223	26	to	to	PART
admet-547	223	27	measure	measure	VERB
admet-547	223	28	in	in	ADP
admet-547	223	29	vivo	vivo	NOUN
admet-547	223	30	due	due	ADP
admet-547	223	31	to	to	ADP
admet-547	223	32	the	the	DET
admet-547	223	33	technical	technical	ADJ
admet-547	223	34	difficulties	difficulty	NOUN
admet-547	223	35	of	of	ADP
admet-547	223	36	detecting	detect	VERB
admet-547	223	37	gm6	gm6	PROPN
admet-547	223	38	in	in	ADP
admet-547	223	39	human	human	ADJ
admet-547	223	40	blood	blood	NOUN
admet-547	223	41	.	.	PUNCT
admet-547	224	1	at	at	ADP
admet-547	224	2	this	this	DET
admet-547	224	3	stage	stage	NOUN
admet-547	224	4	,	,	PUNCT
admet-547	224	5	the	the	DET
admet-547	224	6	renal	renal	ADJ
admet-547	224	7	clearance	clearance	NOUN
admet-547	224	8	of	of	ADP
admet-547	224	9	the	the	DET
admet-547	224	10	compound	compound	NOUN
admet-547	224	11	had	have	AUX
admet-547	224	12	not	not	PART
admet-547	224	13	been	be	AUX
admet-547	224	14	tested	test	VERB
admet-547	224	15	.	.	PUNCT
admet-547	225	1	even	even	ADV
admet-547	225	2	if	if	SCONJ
admet-547	225	3	the	the	DET
admet-547	225	4	elimination	elimination	NOUN
admet-547	225	5	rate	rate	NOUN
admet-547	225	6	is	be	AUX
admet-547	225	7	double	double	ADJ
admet-547	225	8	(	(	PUNCT
admet-547	225	9	30	30	NUM
admet-547	225	10	ml	ml	NOUN
admet-547	225	11	/	/	SYM
admet-547	225	12	min	min	NOUN
admet-547	225	13	/	/	SYM
admet-547	225	14	kg	kg	NOUN
admet-547	225	15	)	)	PUNCT
admet-547	225	16	due	due	ADP
admet-547	225	17	to	to	ADP
admet-547	225	18	renal	renal	ADJ
admet-547	225	19	clearance	clearance	NOUN
admet-547	225	20	of	of	ADP
admet-547	225	21	gm6	gm6	PROPN
admet-547	225	22	we	we	PRON
admet-547	225	23	can	can	AUX
admet-547	225	24	expect	expect	VERB
admet-547	225	25	3	3	NUM
admet-547	225	26	hours	hour	NOUN
admet-547	225	27	half	half	ADJ
admet-547	225	28	-	-	PUNCT
admet-547	225	29	life	life	NOUN
admet-547	225	30	in	in	ADP
admet-547	225	31	the	the	DET
admet-547	225	32	tissues	tissue	NOUN
admet-547	225	33	when	when	SCONJ
admet-547	225	34	calculated	calculate	VERB
admet-547	225	35	using	use	VERB
admet-547	225	36	equation	equation	NOUN
admet-547	225	37	5	5	NUM
admet-547	225	38	.	.	PUNCT
admet-547	225	39	conclusions	conclusion	NOUN
admet-547	225	40	in	in	ADP
admet-547	225	41	this	this	DET
admet-547	225	42	paper	paper	NOUN
admet-547	225	43	,	,	PUNCT
admet-547	225	44	results	result	NOUN
admet-547	225	45	have	have	AUX
admet-547	225	46	been	be	AUX
admet-547	225	47	shown	show	VERB
admet-547	225	48	and	and	CCONJ
admet-547	225	49	discussed	discuss	VERB
admet-547	225	50	for	for	ADP
admet-547	225	51	a	a	DET
admet-547	225	52	6	6	NUM
admet-547	225	53	-	-	PUNCT
admet-547	225	54	amino	amino	NOUN
admet-547	225	55	acid	acid	NOUN
admet-547	225	56	fragment	fragment	NOUN
admet-547	225	57	(	(	PUNCT
admet-547	225	58	gm6	gm6	PROPN
admet-547	225	59	)	)	PUNCT
admet-547	225	60	of	of	ADP
admet-547	225	61	the	the	DET
admet-547	225	62	endogenous	endogenous	ADJ
admet-547	225	63	motor	motor	NOUN
admet-547	225	64	neuron	neuron	PROPN
admet-547	225	65	trophic	trophic	ADJ
admet-547	225	66	factor	factor	NOUN
admet-547	225	67	(	(	PUNCT
admet-547	225	68	mntf	mntf	VERB
admet-547	225	69	)	)	PUNCT
admet-547	225	70	containing	contain	VERB
admet-547	225	71	33	33	NUM
admet-547	225	72	amino	amino	ADJ
admet-547	225	73	acids	acid	NOUN
admet-547	225	74	and	and	CCONJ
admet-547	225	75	further	far	ADV
admet-547	225	76	discussed	discuss	VERB
admet-547	225	77	as	as	ADP
admet-547	225	78	a	a	DET
admet-547	225	79	potential	potential	ADJ
admet-547	225	80	peptide	peptide	NOUN
admet-547	225	81	therapeutic	therapeutic	ADJ
admet-547	225	82	for	for	ADP
admet-547	225	83	amyotrophic	amyotrophic	ADJ
admet-547	225	84	lateral	lateral	ADJ
admet-547	225	85	sclerosis	sclerosis	NOUN
admet-547	225	86	(	(	PUNCT
admet-547	225	87	als	als	NOUN
admet-547	225	88	)	)	PUNCT
admet-547	225	89	.	.	PUNCT
admet-547	226	1	the	the	DET
admet-547	226	2	physicochemical	physicochemical	ADJ
admet-547	226	3	properties	property	NOUN
admet-547	226	4	of	of	ADP
admet-547	226	5	gm6	gm6	PROPN
admet-547	226	6	were	be	AUX
admet-547	226	7	measured	measure	VERB
admet-547	226	8	using	use	VERB
admet-547	226	9	biomimetic	biomimetic	ADJ
admet-547	226	10	hplc	hplc	NOUN
admet-547	226	11	membrane	membrane	NOUN
admet-547	226	12	and	and	CCONJ
admet-547	226	13	protein	protein	NOUN
admet-547	226	14	binding	bind	VERB
admet-547	226	15	.	.	PUNCT
admet-547	227	1	gm6	gm6	PROPN
admet-547	227	2	showed	show	VERB
admet-547	227	3	very	very	ADV
admet-547	227	4	good	good	ADJ
admet-547	227	5	druglike	druglike	NOUN
admet-547	227	6	properties	property	NOUN
admet-547	227	7	.	.	PUNCT
admet-547	228	1	due	due	ADP
admet-547	228	2	to	to	ADP
admet-547	228	3	the	the	DET
admet-547	228	4	two	two	NUM
admet-547	228	5	positively	positively	ADV
admet-547	228	6	charged	charge	VERB
admet-547	228	7	arginine	arginine	NOUN
admet-547	228	8	amino	amino	NOUN
admet-547	228	9	acids	acid	NOUN
admet-547	228	10	and	and	CCONJ
admet-547	228	11	based	base	VERB
admet-547	228	12	on	on	ADP
admet-547	228	13	the	the	DET
admet-547	228	14	measured	measured	ADJ
admet-547	228	15	phospholipid	phospholipid	NOUN
admet-547	228	16	and	and	CCONJ
admet-547	228	17	protein	protein	NOUN
admet-547	228	18	binding	bind	VERB
admet-547	228	19	,	,	PUNCT
admet-547	228	20	gm6	gm6	PROPN
admet-547	228	21	has	have	AUX
admet-547	228	22	been	be	AUX
admet-547	228	23	predicted	predict	VERB
admet-547	228	24	to	to	PART
admet-547	228	25	have	have	VERB
admet-547	228	26	very	very	ADV
admet-547	228	27	strong	strong	ADJ
admet-547	228	28	tissue	tissue	NOUN
admet-547	228	29	partition	partition	NOUN
admet-547	228	30	with	with	ADP
admet-547	228	31	an	an	DET
admet-547	228	32	estimated	estimate	VERB
admet-547	228	33	volume	volume	NOUN
admet-547	228	34	of	of	ADP
admet-547	228	35	distribution	distribution	NOUN
admet-547	228	36	of	of	ADP
admet-547	228	37	7.8	7.8	NUM
admet-547	228	38	l	l	NOUN
admet-547	229	1	/	/	SYM
admet-547	229	2	kg	kg	NOUN
admet-547	229	3	.	.	PUNCT
admet-547	230	1	it	it	PRON
admet-547	230	2	was	be	AUX
admet-547	230	3	also	also	ADV
admet-547	230	4	predicted	predict	VERB
admet-547	230	5	that	that	SCONJ
admet-547	230	6	it	it	PRON
admet-547	230	7	partitions	partition	VERB
admet-547	230	8	into	into	ADP
admet-547	230	9	cells	cell	NOUN
admet-547	230	10	(	(	PUNCT
admet-547	230	11	kpcell	kpcell	NOUN
admet-547	230	12	=	=	NOUN
admet-547	230	13	5.2	5.2	NUM
admet-547	230	14	)	)	PUNCT
admet-547	230	15	and	and	CCONJ
admet-547	230	16	has	have	VERB
admet-547	230	17	a	a	DET
admet-547	230	18	good	good	ADJ
admet-547	230	19	brain	brain	NOUN
admet-547	230	20	to	to	ADP
admet-547	230	21	plasma	plasma	NOUN
admet-547	230	22	ratio	ratio	NOUN
admet-547	230	23	(	(	PUNCT
admet-547	230	24	1.65	1.65	NUM
admet-547	230	25	)	)	PUNCT
admet-547	230	26	.	.	PUNCT
admet-547	231	1	studies	study	NOUN
admet-547	231	2	in	in	ADP
admet-547	231	3	mice	mice	NOUN
admet-547	231	4	show	show	NOUN
admet-547	231	5	penetration	penetration	NOUN
admet-547	231	6	of	of	ADP
admet-547	231	7	the	the	DET
admet-547	231	8	gm6	gm6	PROPN
admet-547	231	9	into	into	ADP
admet-547	231	10	the	the	DET
admet-547	231	11	brain	brain	NOUN
admet-547	231	12	following	follow	VERB
admet-547	231	13	a	a	DET
admet-547	231	14	bolus	bolus	NOUN
admet-547	231	15	iv	iv	NUM
admet-547	231	16	injection	injection	NOUN
admet-547	231	17	with	with	ADP
admet-547	231	18	the	the	DET
admet-547	231	19	drug	drug	NOUN
admet-547	231	20	still	still	ADV
admet-547	231	21	present	present	ADJ
admet-547	231	22	after	after	ADP
admet-547	231	23	four	four	NUM
admet-547	231	24	hours	hour	NOUN
admet-547	231	25	.	.	PUNCT
admet-547	232	1	the	the	DET
admet-547	232	2	concentration	concentration	NOUN
admet-547	232	3	of	of	ADP
admet-547	232	4	gm6	gm6	PROPN
admet-547	232	5	klara	klara	PROPN
admet-547	232	6	valko	valko	PROPN
admet-547	232	7	et	et	PROPN
admet-547	232	8	al	al	PROPN
admet-547	232	9	.	.	PROPN
admet-547	232	10	admet	admet	PROPN
admet-547	232	11	&	&	CCONJ
admet-547	232	12	dmpk	dmpk	PROPN
admet-547	232	13	6(2	6(2	NUM
admet-547	232	14	)	)	PUNCT
admet-547	232	15	(	(	PUNCT
admet-547	232	16	2018	2018	NUM
admet-547	232	17	)	)	PUNCT
admet-547	232	18	176	176	NUM
admet-547	232	19	-	-	SYM
admet-547	232	20	189	189	NUM
admet-547	232	21	188	188	NUM
admet-547	232	22	decreased	decrease	VERB
admet-547	232	23	rapidly	rapidly	ADV
admet-547	232	24	in	in	ADP
admet-547	232	25	blood	blood	NOUN
admet-547	232	26	suggesting	suggest	VERB
admet-547	232	27	a	a	DET
admet-547	232	28	high	high	ADJ
admet-547	232	29	affinity	affinity	NOUN
admet-547	232	30	for	for	ADP
admet-547	232	31	target	target	NOUN
admet-547	232	32	sites	site	NOUN
admet-547	232	33	in	in	ADP
admet-547	232	34	the	the	DET
admet-547	232	35	brain	brain	NOUN
admet-547	232	36	and/or	and/or	CCONJ
admet-547	232	37	active	active	ADJ
admet-547	232	38	uptake	uptake	NOUN
admet-547	232	39	into	into	ADP
admet-547	232	40	brain	brain	NOUN
admet-547	232	41	cells	cell	NOUN
admet-547	232	42	and	and	CCONJ
admet-547	232	43	gaba	gaba	NOUN
admet-547	232	44	-	-	PUNCT
admet-547	232	45	ergic	ergic	NOUN
admet-547	232	46	neuron	neuron	NOUN
admet-547	232	47	cells	cell	NOUN
admet-547	232	48	as	as	SCONJ
admet-547	232	49	shown	show	VERB
admet-547	232	50	by	by	ADP
admet-547	232	51	immunofluorescence	immunofluorescence	NOUN
admet-547	232	52	imaging	imaging	NOUN
admet-547	232	53	studies	study	NOUN
admet-547	232	54	.	.	PUNCT
admet-547	233	1	the	the	DET
admet-547	233	2	estimated	estimate	VERB
admet-547	233	3	free	free	ADJ
admet-547	233	4	tissue	tissue	NOUN
admet-547	233	5	concentration	concentration	NOUN
admet-547	233	6	–	–	PUNCT
admet-547	233	7	time	time	NOUN
admet-547	233	8	profile	profile	NOUN
admet-547	233	9	based	base	VERB
admet-547	233	10	on	on	ADP
admet-547	233	11	only	only	ADJ
admet-547	233	12	microsomal	microsomal	ADJ
admet-547	233	13	elimination	elimination	NOUN
admet-547	233	14	showed	show	VERB
admet-547	233	15	approximately	approximately	ADV
admet-547	233	16	6	6	NUM
admet-547	233	17	hours	hour	NOUN
admet-547	233	18	half	half	ADJ
admet-547	233	19	-	-	PUNCT
admet-547	233	20	life	life	NOUN
admet-547	233	21	.	.	PUNCT
admet-547	234	1	the	the	DET
admet-547	234	2	in	in	ADP
admet-547	234	3	vivo	vivo	ADJ
admet-547	234	4	beneficial	beneficial	ADJ
admet-547	234	5	effects	effect	NOUN
admet-547	234	6	of	of	ADP
admet-547	234	7	gm6	gm6	PROPN
admet-547	234	8	are	be	AUX
admet-547	234	9	longer	long	ADV
admet-547	234	10	lasting	last	VERB
admet-547	234	11	.	.	PUNCT
admet-547	235	1	this	this	PRON
admet-547	235	2	would	would	AUX
admet-547	235	3	indicate	indicate	VERB
admet-547	235	4	that	that	SCONJ
admet-547	235	5	it	it	PRON
admet-547	235	6	probably	probably	ADV
admet-547	235	7	provokes	provoke	VERB
admet-547	235	8	a	a	DET
admet-547	235	9	cascade	cascade	NOUN
admet-547	235	10	of	of	ADP
admet-547	235	11	biochemical	biochemical	ADJ
admet-547	235	12	events	event	NOUN
admet-547	235	13	,	,	PUNCT
admet-547	235	14	after	after	ADP
admet-547	235	15	initial	initial	ADJ
admet-547	235	16	binding	binding	NOUN
admet-547	235	17	,	,	PUNCT
admet-547	235	18	and	and	CCONJ
admet-547	235	19	that	that	PRON
admet-547	235	20	influences	influence	VERB
admet-547	235	21	multiple	multiple	ADJ
admet-547	235	22	pathways	pathway	NOUN
admet-547	235	23	that	that	PRON
admet-547	235	24	promote	promote	VERB
admet-547	235	25	neuron	neuron	NOUN
admet-547	235	26	regeneration	regeneration	NOUN
admet-547	235	27	.	.	PUNCT
admet-547	236	1	references	reference	NOUN
admet-547	236	2	[	[	X
admet-547	236	3	1	1	X
admet-547	236	4	]	]	PUNCT
admet-547	236	5	s.	s.	PROPN
admet-547	236	6	przedborski	przedborski	PROPN
admet-547	236	7	,	,	PUNCT
admet-547	236	8	h.	h.	PROPN
admet-547	236	9	mitsumoto	mitsumoto	PROPN
admet-547	236	10	,	,	PUNCT
admet-547	236	11	l.p	l.p	PROPN
admet-547	236	12	.	.	PROPN
admet-547	236	13	rowland	rowland	PROPN
admet-547	236	14	.	.	PUNCT
admet-547	237	1	recent	recent	ADJ
admet-547	237	2	advances	advance	NOUN
admet-547	237	3	in	in	ADP
admet-547	237	4	amyotrophic	amyotrophic	ADJ
admet-547	237	5	lateral	lateral	ADJ
admet-547	237	6	sclerosis	sclerosis	NOUN
admet-547	237	7	research	research	NOUN
admet-547	237	8	.	.	PUNCT
admet-547	238	1	curr	curr	PROPN
admet-547	238	2	.	.	PUNCT
admet-547	239	1	neurol	neurol	PROPN
admet-547	239	2	.	.	PUNCT
admet-547	240	1	neurosci	neurosci	PROPN
admet-547	240	2	.	.	PUNCT
admet-547	241	1	rep	rep	PROPN
admet-547	241	2	.	.	PROPN
admet-547	241	3	3	3	NUM
admet-547	241	4	(	(	PUNCT
admet-547	241	5	2003	2003	NUM
admet-547	241	6	)	)	PUNCT
admet-547	241	7	70–77	70–77	NUM
admet-547	241	8	.	.	PUNCT
admet-547	242	1	[	[	X
admet-547	242	2	2	2	NUM
admet-547	242	3	]	]	X
admet-547	242	4	m.c	m.c	PROPN
admet-547	242	5	.	.	PROPN
admet-547	242	6	kiernan	kiernan	PROPN
admet-547	242	7	,	,	PUNCT
admet-547	242	8	s.	s.	PROPN
admet-547	242	9	vučić	vučić	PROPN
admet-547	242	10	,	,	PUNCT
admet-547	242	11	b.s	b.s	PROPN
admet-547	242	12	.	.	PROPN
admet-547	242	13	cheah	cheah	PROPN
admet-547	242	14	,	,	PUNCT
admet-547	242	15	m.r	m.r	PROPN
admet-547	242	16	.	.	PROPN
admet-547	242	17	turner	turner	PROPN
admet-547	242	18	,	,	PUNCT
admet-547	242	19	a.	a.	NOUN
admet-547	242	20	eisen	eisen	PROPN
admet-547	242	21	,	,	PUNCT
admet-547	242	22	o.	o.	PROPN
admet-547	242	23	hardiman	hardiman	PROPN
admet-547	242	24	,	,	PUNCT
admet-547	242	25	j.r	j.r	PROPN
admet-547	242	26	.	.	PROPN
admet-547	242	27	burrel	burrel	PROPN
admet-547	242	28	,	,	PUNCT
admet-547	242	29	m.c	m.c	PROPN
admet-547	242	30	.	.	PROPN
admet-547	242	31	zoing	zoing	PROPN
admet-547	242	32	.	.	PUNCT
admet-547	243	1	amyotrophic	amyotrophic	ADJ
admet-547	243	2	lateral	lateral	ADJ
admet-547	243	3	sclerosis	sclerosis	NOUN
admet-547	243	4	.	.	PUNCT
admet-547	244	1	lancet	lancet	PROPN
admet-547	244	2	(	(	PUNCT
admet-547	244	3	london	london	PROPN
admet-547	244	4	,	,	PUNCT
admet-547	244	5	england	england	PROPN
admet-547	244	6	)	)	PUNCT
admet-547	244	7	377	377	NUM
admet-547	244	8	(	(	PUNCT
admet-547	244	9	2011	2011	NUM
admet-547	244	10	)	)	PUNCT
admet-547	244	11	942–955	942–955	NUM
admet-547	244	12	.	.	PUNCT
admet-547	245	1	[	[	X
admet-547	245	2	3	3	NUM
admet-547	245	3	]	]	X
admet-547	245	4	p.	p.	NOUN
admet-547	245	5	pasinelli	pasinelli	PROPN
admet-547	245	6	,	,	PUNCT
admet-547	245	7	r.h	r.h	PROPN
admet-547	245	8	.	.	PROPN
admet-547	245	9	brown	brown	PROPN
admet-547	245	10	.	.	PUNCT
admet-547	246	1	molecular	molecular	ADJ
admet-547	246	2	biology	biology	NOUN
admet-547	246	3	of	of	ADP
admet-547	246	4	amyotrophic	amyotrophic	ADJ
admet-547	246	5	lateral	lateral	ADJ
admet-547	246	6	sclerosis	sclerosis	NOUN
admet-547	246	7	:	:	PUNCT
admet-547	246	8	insights	insight	NOUN
admet-547	246	9	from	from	ADP
admet-547	246	10	genetics	genetic	NOUN
admet-547	246	11	.	.	PUNCT
admet-547	247	1	nat	nat	PROPN
admet-547	247	2	.	.	PUNCT
admet-547	248	1	rev	rev	PROPN
admet-547	248	2	.	.	PROPN
admet-547	248	3	neurosci	neurosci	PROPN
admet-547	248	4	.	.	PUNCT
admet-547	249	1	7	7	NUM
admet-547	249	2	(	(	PUNCT
admet-547	249	3	2006	2006	NUM
admet-547	249	4	)	)	PUNCT
admet-547	250	1	710–723	710–723	NUM
admet-547	250	2	.	.	PUNCT
admet-547	251	1	[	[	X
admet-547	251	2	4	4	NUM
admet-547	251	3	]	]	X
admet-547	251	4	r.e	r.e	PROPN
admet-547	251	5	.	.	PROPN
admet-547	251	6	ellis	ellis	PROPN
admet-547	251	7	,	,	PUNCT
admet-547	251	8	j.y	j.y	PROPN
admet-547	251	9	.	.	PROPN
admet-547	251	10	yuan	yuan	PROPN
admet-547	251	11	,	,	PUNCT
admet-547	251	12	h.r	h.r	PROPN
admet-547	251	13	.	.	PROPN
admet-547	251	14	horvitz	horvitz	PROPN
admet-547	251	15	.	.	PUNCT
admet-547	252	1	mechanisms	mechanism	NOUN
admet-547	252	2	and	and	CCONJ
admet-547	252	3	functions	function	NOUN
admet-547	252	4	of	of	ADP
admet-547	252	5	cell	cell	NOUN
admet-547	252	6	death	death	NOUN
admet-547	252	7	.	.	PUNCT
admet-547	253	1	annu	annu	NOUN
admet-547	253	2	.	.	PUNCT
admet-547	254	1	rev	rev	PROPN
admet-547	254	2	.	.	PROPN
admet-547	254	3	cell	cell	PROPN
admet-547	254	4	biol	biol	PROPN
admet-547	254	5	.	.	PUNCT
admet-547	255	1	7	7	NUM
admet-547	255	2	(	(	PUNCT
admet-547	255	3	1991	1991	NUM
admet-547	255	4	)	)	PUNCT
admet-547	256	1	663–698	663–698	NUM
admet-547	256	2	.	.	PUNCT
admet-547	257	1	[	[	X
admet-547	257	2	5	5	NUM
admet-547	257	3	]	]	X
admet-547	257	4	e.t	e.t	PROPN
admet-547	257	5	.	.	PROPN
admet-547	257	6	reyes	reyes	PROPN
admet-547	257	7	,	,	PUNCT
admet-547	257	8	o.h	o.h	PROPN
admet-547	257	9	.	.	PROPN
admet-547	257	10	perurena	perurena	PROPN
admet-547	257	11	,	,	PUNCT
admet-547	257	12	b.w	b.w	PROPN
admet-547	257	13	.	.	PROPN
admet-547	257	14	festoff	festoff	PROPN
admet-547	257	15	,	,	PUNCT
admet-547	257	16	r.	r.	PROPN
admet-547	257	17	jorgensen	jorgensen	PROPN
admet-547	257	18	,	,	PUNCT
admet-547	257	19	w.v	w.v	PROPN
admet-547	257	20	moore	moore	PROPN
admet-547	257	21	.	.	PUNCT
admet-547	258	1	insulin	insulin	NOUN
admet-547	258	2	resistance	resistance	NOUN
admet-547	258	3	in	in	ADP
admet-547	258	4	amyotrophic	amyotrophic	ADJ
admet-547	258	5	lateral	lateral	ADJ
admet-547	258	6	sclerosis	sclerosis	NOUN
admet-547	258	7	.	.	PUNCT
admet-547	259	1	j.	j.	PROPN
admet-547	259	2	neurol	neurol	PROPN
admet-547	259	3	.	.	PUNCT
admet-547	260	1	sci	sci	PROPN
admet-547	260	2	.	.	PROPN
admet-547	260	3	63	63	NUM
admet-547	260	4	(	(	PUNCT
admet-547	260	5	1984	1984	NUM
admet-547	260	6	)	)	PUNCT
admet-547	261	1	317–324	317–324	NUM
admet-547	261	2	.	.	PUNCT
admet-547	262	1	[	[	X
admet-547	262	2	6	6	NUM
admet-547	262	3	]	]	PUNCT
admet-547	262	4	s.	s.	PROPN
admet-547	262	5	cohen	cohen	PROPN
admet-547	262	6	.	.	PUNCT
admet-547	263	1	purification	purification	NOUN
admet-547	263	2	of	of	ADP
admet-547	263	3	a	a	DET
admet-547	263	4	nerve	nerve	NOUN
admet-547	263	5	-	-	PUNCT
admet-547	263	6	growth	growth	NOUN
admet-547	263	7	promoting	promote	VERB
admet-547	263	8	protein	protein	NOUN
admet-547	263	9	from	from	ADP
admet-547	263	10	the	the	DET
admet-547	263	11	mouse	mouse	NOUN
admet-547	263	12	salivary	salivary	ADJ
admet-547	263	13	gland	gland	NOUN
admet-547	263	14	and	and	CCONJ
admet-547	263	15	its	its	PRON
admet-547	263	16	neuro	neuro	NOUN
admet-547	263	17	-	-	PUNCT
admet-547	263	18	cytotxic	cytotxic	NOUN
admet-547	263	19	antiserum	antiserum	NOUN
admet-547	263	20	.	.	PUNCT
admet-547	264	1	proc	proc	PROPN
admet-547	264	2	.	.	PUNCT
admet-547	265	1	natl	natl	PROPN
admet-547	265	2	.	.	PUNCT
admet-547	266	1	acad	acad	PROPN
admet-547	266	2	.	.	PUNCT
admet-547	267	1	sci	sci	PROPN
admet-547	267	2	.	.	PUNCT
admet-547	268	1	u.	u.	PROPN
admet-547	268	2	s.	s.	PROPN
admet-547	268	3	a.	a.	PROPN
admet-547	268	4	46	46	NUM
admet-547	268	5	(	(	PUNCT
admet-547	268	6	1960	1960	NUM
admet-547	268	7	)	)	PUNCT
admet-547	269	1	302–311	302–311	NUM
admet-547	269	2	.	.	PUNCT
admet-547	270	1	[	[	X
admet-547	270	2	7	7	NUM
admet-547	270	3	]	]	X
admet-547	270	4	i.a	i.a	PROPN
admet-547	270	5	.	.	PROPN
admet-547	270	6	hendry	hendry	PROPN
admet-547	270	7	,	,	PUNCT
admet-547	270	8	k.	k.	PROPN
admet-547	270	9	stöckel	stöckel	PROPN
admet-547	270	10	,	,	PUNCT
admet-547	270	11	h.	h.	PROPN
admet-547	270	12	thoenen	thoenen	PROPN
admet-547	270	13	,	,	PUNCT
admet-547	270	14	l.l	l.l	PROPN
admet-547	270	15	.	.	PROPN
admet-547	270	16	iversen	iversen	PROPN
admet-547	270	17	.	.	PUNCT
admet-547	271	1	the	the	DET
admet-547	271	2	retrograde	retrograde	ADJ
admet-547	271	3	axonal	axonal	ADJ
admet-547	271	4	transport	transport	NOUN
admet-547	271	5	of	of	ADP
admet-547	271	6	nerve	nerve	NOUN
admet-547	271	7	growth	growth	NOUN
admet-547	271	8	factor	factor	NOUN
admet-547	271	9	.	.	PUNCT
admet-547	272	1	brain	brain	NOUN
admet-547	272	2	res	re	NOUN
admet-547	272	3	.	.	PUNCT
admet-547	273	1	68	68	NUM
admet-547	273	2	(	(	PUNCT
admet-547	273	3	1974	1974	NUM
admet-547	273	4	)	)	PUNCT
admet-547	273	5	103–121	103–121	NUM
admet-547	273	6	.	.	PUNCT
admet-547	274	1	[	[	X
admet-547	274	2	8	8	NUM
admet-547	274	3	]	]	X
admet-547	274	4	r.m	r.m	PROPN
admet-547	274	5	.	.	PROPN
admet-547	274	6	wah	wah	PROPN
admet-547	274	7	.	.	PUNCT
admet-547	275	1	polynucleotides	polynucleotide	NOUN
admet-547	275	2	encoding	encode	VERB
admet-547	275	3	motoneurontrophic	motoneurontrophic	ADJ
admet-547	275	4	factors	factor	NOUN
admet-547	275	5	.	.	PUNCT
admet-547	276	1	us	we	PRON
admet-547	276	2	patent	patent	NOUN
admet-547	276	3	6309877	6309877	NUM
admet-547	276	4	.	.	PUNCT
admet-547	277	1	[	[	X
admet-547	277	2	9	9	NUM
admet-547	277	3	]	]	X
admet-547	277	4	r.m.w	r.m.w	NOUN
admet-547	277	5	.	.	PUNCT
admet-547	277	6	chau	chau	PROPN
admet-547	277	7	,	,	PUNCT
admet-547	277	8	p.-y.d.ko	p.-y.d.ko	PROPN
admet-547	277	9	.	.	PUNCT
admet-547	278	1	hong	hong	PROPN
admet-547	278	2	kong	kong	PROPN
admet-547	278	3	.	.	PUNCT
admet-547	279	1	mntf	mntf	VERB
admet-547	279	2	peptides	peptide	NOUN
admet-547	279	3	and	and	CCONJ
admet-547	279	4	compositions	composition	NOUN
admet-547	279	5	and	and	CCONJ
admet-547	279	6	methods	method	NOUN
admet-547	279	7	of	of	ADP
admet-547	279	8	use	use	NOUN
admet-547	279	9	.	.	PUNCT
admet-547	280	1	us	we	PRON
admet-547	280	2	patent	patent	NOUN
admet-547	280	3	7183373	7183373	NUM
admet-547	280	4	,	,	PUNCT
admet-547	280	5	(	(	PUNCT
admet-547	280	6	2007	2007	NUM
admet-547	280	7	)	)	PUNCT
admet-547	280	8	.	.	PUNCT
admet-547	281	1	[	[	X
admet-547	281	2	10	10	NUM
admet-547	281	3	]	]	X
admet-547	281	4	d.m	d.m	PROPN
admet-547	281	5	.	.	PUNCT
admet-547	281	6	deshpande	deshpande	PROPN
admet-547	281	7	,	,	PUNCT
admet-547	281	8	d.	d.	PROPN
admet-547	281	9	a.	a.	PROPN
admet-547	281	10	kerr	kerr	PROPN
admet-547	281	11	,	,	PUNCT
admet-547	281	12	m.	m.	NOUN
admet-547	281	13	ruxton	ruxton	PROPN
admet-547	281	14	,	,	PUNCT
admet-547	281	15	d.p.-y	d.p.-y	NOUN
admet-547	281	16	.	.	PUNCT
admet-547	282	1	ko	ko	PROPN
admet-547	282	2	.	.	PROPN
admet-547	283	1	nmntf	nmntf	PROPN
admet-547	283	2	differentiation	differentiation	NOUN
admet-547	283	3	and	and	CCONJ
admet-547	283	4	growth	growth	NOUN
admet-547	283	5	of	of	ADP
admet-547	283	6	stem	stem	NOUN
admet-547	283	7	cellso	cellso	ADJ
admet-547	283	8	title	title	NOUN
admet-547	283	9	.	.	PUNCT
admet-547	284	1	us	we	PRON
admet-547	284	2	patent	patent	NOUN
admet-547	284	3	no	no	DET
admet-547	284	4	8986676	8986676	NUM
admet-547	284	5	,	,	PUNCT
admet-547	284	6	(	(	PUNCT
admet-547	284	7	2015	2015	NUM
admet-547	284	8	)	)	PUNCT
admet-547	284	9	.	.	PUNCT
admet-547	285	1	[	[	X
admet-547	285	2	11	11	NUM
admet-547	285	3	]	]	PUNCT
admet-547	285	4	k.	k.	NOUN
admet-547	285	5	fosgerau	fosgerau	PROPN
admet-547	285	6	,	,	PUNCT
admet-547	285	7	t.	t.	PROPN
admet-547	285	8	hoffmann	hoffmann	PROPN
admet-547	285	9	.	.	PUNCT
admet-547	286	1	peptide	peptide	NOUN
admet-547	286	2	therapeutics	therapeutic	NOUN
admet-547	286	3	:	:	PUNCT
admet-547	286	4	current	current	ADJ
admet-547	286	5	status	status	NOUN
admet-547	286	6	and	and	CCONJ
admet-547	286	7	future	future	ADJ
admet-547	286	8	directions	direction	NOUN
admet-547	286	9	.	.	PUNCT
admet-547	287	1	drug	drug	NOUN
admet-547	287	2	discov	discov	NOUN
admet-547	287	3	.	.	PUNCT
admet-547	288	1	today	today	NOUN
admet-547	288	2	20	20	NUM
admet-547	288	3	(	(	PUNCT
admet-547	288	4	2015	2015	NUM
admet-547	288	5	)	)	PUNCT
admet-547	288	6	122–128	122–128	NUM
admet-547	288	7	.	.	PUNCT
admet-547	289	1	[	[	X
admet-547	289	2	12	12	NUM
admet-547	289	3	]	]	X
admet-547	289	4	k.l	k.l	PROPN
admet-547	289	5	.	.	PROPN
admet-547	289	6	valkó	valkó	PROPN
admet-547	289	7	.	.	PUNCT
admet-547	290	1	lipophilicity	lipophilicity	NOUN
admet-547	290	2	and	and	CCONJ
admet-547	290	3	biomimetic	biomimetic	ADJ
admet-547	290	4	properties	property	NOUN
admet-547	290	5	measured	measure	VERB
admet-547	290	6	by	by	ADP
admet-547	290	7	hplc	hplc	NOUN
admet-547	290	8	to	to	PART
admet-547	290	9	support	support	VERB
admet-547	290	10	drug	drug	NOUN
admet-547	290	11	discovery	discovery	NOUN
admet-547	290	12	.	.	PUNCT
admet-547	291	1	j.	j.	PROPN
admet-547	291	2	pharm	pharm	PROPN
admet-547	291	3	.	.	PUNCT
admet-547	291	4	biomed	biome	VERB
admet-547	291	5	.	.	PUNCT
admet-547	292	1	anal	anal	ADJ
admet-547	292	2	.	.	PUNCT
admet-547	293	1	130	130	NUM
admet-547	293	2	(	(	PUNCT
admet-547	293	3	2016	2016	NUM
admet-547	293	4	)	)	PUNCT
admet-547	293	5	35–54	35–54	NUM
admet-547	293	6	.	.	PUNCT
admet-547	294	1	[	[	X
admet-547	294	2	13	13	NUM
admet-547	294	3	]	]	X
admet-547	294	4	k.l	k.l	PROPN
admet-547	294	5	.	.	PROPN
admet-547	294	6	valko	valko	PROPN
admet-547	294	7	,	,	PUNCT
admet-547	294	8	s.p	s.p	PROPN
admet-547	294	9	.	.	PROPN
admet-547	294	10	teague	teague	PROPN
admet-547	294	11	,	,	PUNCT
admet-547	294	12	c.	c.	PROPN
admet-547	294	13	pidgeon	pidgeon	PROPN
admet-547	294	14	.	.	PUNCT
admet-547	295	1	in	in	ADP
admet-547	295	2	vitro	vitro	X
admet-547	295	3	membrane	membrane	NOUN
admet-547	295	4	binding	bind	VERB
admet-547	295	5	and	and	CCONJ
admet-547	295	6	protein	protein	NOUN
admet-547	295	7	binding	bind	VERB
admet-547	295	8	(	(	PUNCT
admet-547	295	9	iam	iam	PROPN
admet-547	295	10	mb	mb	PROPN
admet-547	295	11	/	/	SYM
admet-547	295	12	pb	pb	X
admet-547	295	13	technology	technology	NOUN
admet-547	295	14	)	)	PUNCT
admet-547	295	15	to	to	PART
admet-547	295	16	estimate	estimate	VERB
admet-547	295	17	in	in	ADP
admet-547	295	18	vivo	vivo	ADJ
admet-547	295	19	distribution	distribution	NOUN
admet-547	295	20	:	:	PUNCT
admet-547	295	21	applications	application	NOUN
admet-547	295	22	in	in	ADP
admet-547	295	23	early	early	ADJ
admet-547	295	24	drug	drug	NOUN
admet-547	295	25	discovery	discovery	NOUN
admet-547	295	26	.	.	PUNCT
admet-547	296	1	admet	admet	PROPN
admet-547	296	2	dmpk	dmpk	PROPN
admet-547	296	3	5	5	NUM
admet-547	296	4	(	(	PUNCT
admet-547	296	5	2017	2017	NUM
admet-547	296	6	)	)	PUNCT
admet-547	296	7	14	14	NUM
admet-547	296	8	-	-	SYM
admet-547	296	9	38	38	NUM
admet-547	296	10	.	.	PUNCT
admet-547	297	1	[	[	X
admet-547	297	2	14	14	NUM
admet-547	297	3	]	]	PUNCT
admet-547	297	4	k.	k.	PROPN
admet-547	297	5	valko	valko	PROPN
admet-547	297	6	,	,	PUNCT
admet-547	297	7	g.	g.	PROPN
admet-547	297	8	ivanova	ivanova	PROPN
admet-547	297	9	-	-	PUNCT
admet-547	297	10	berndt	berndt	PROPN
admet-547	297	11	,	,	PUNCT
admet-547	297	12	p.	p.	PROPN
admet-547	297	13	beswick	beswick	PROPN
admet-547	297	14	,	,	PUNCT
admet-547	297	15	m.	m.	PROPN
admet-547	297	16	kindey	kindey	PROPN
admet-547	297	17	,	,	PUNCT
admet-547	297	18	d.	d.	PROPN
admet-547	297	19	ko	ko	PROPN
admet-547	297	20	.	.	PUNCT
admet-547	298	1	application	application	NOUN
admet-547	298	2	of	of	ADP
admet-547	298	3	biomimetic	biomimetic	ADJ
admet-547	298	4	hplc	hplc	NOUN
admet-547	298	5	to	to	PART
admet-547	298	6	estimate	estimate	VERB
admet-547	298	7	lipophilicity	lipophilicity	NOUN
admet-547	298	8	,	,	PUNCT
admet-547	298	9	protein	protein	NOUN
admet-547	298	10	and	and	CCONJ
admet-547	298	11	phospholipid	phospholipid	NOUN
admet-547	298	12	binding	bind	VERB
admet-547	298	13	of	of	ADP
admet-547	298	14	potential	potential	ADJ
admet-547	298	15	peptide	peptide	NOUN
admet-547	298	16	therapeutics	therapeutic	NOUN
admet-547	298	17	.	.	PUNCT
admet-547	299	1	admet	admet	PROPN
admet-547	299	2	dmpk	dmpk	PROPN
admet-547	299	3	(	(	PUNCT
admet-547	299	4	2018	2018	NUM
admet-547	299	5	)	)	PUNCT
admet-547	299	6	http://dx.doi.org/10.5599/admet.544	http://dx.doi.org/10.5599/admet.544	NOUN
admet-547	299	7	.	.	PUNCT
admet-547	300	1	[	[	X
admet-547	300	2	15	15	NUM
admet-547	300	3	]	]	X
admet-547	300	4	m.k	m.k	PROPN
admet-547	300	5	.	.	PROPN
admet-547	300	6	d.	d.	PROPN
admet-547	300	7	ko	ko	PROPN
admet-547	300	8	.	.	PUNCT
admet-547	301	1	methods	method	NOUN
admet-547	301	2	of	of	ADP
admet-547	301	3	treating	treat	VERB
admet-547	301	4	neuronal	neuronal	ADJ
admet-547	301	5	disorders	disorder	NOUN
admet-547	301	6	using	use	VERB
admet-547	301	7	mntf	mntf	VERB
admet-547	301	8	peptides	peptide	NOUN
admet-547	301	9	and	and	CCONJ
admet-547	301	10	analogs	analog	NOUN
admet-547	301	11	.	.	PUNCT
admet-547	302	1	us	us	PROPN
admet-547	302	2	patent	patent	NOUN
admet-547	302	3	8673852	8673852	NUM
admet-547	302	4	,	,	PUNCT
admet-547	302	5	(	(	PUNCT
admet-547	302	6	2014	2014	NUM
admet-547	302	7	)	)	PUNCT
admet-547	302	8	.	.	PUNCT
admet-547	303	1	[	[	X
admet-547	303	2	16	16	NUM
admet-547	303	3	]	]	PUNCT
admet-547	303	4	k.	k.	PROPN
admet-547	303	5	valko	valko	PROPN
admet-547	303	6	,	,	PUNCT
admet-547	303	7	c.	c.	PROPN
admet-547	303	8	du	du	PROPN
admet-547	303	9	,	,	PUNCT
admet-547	303	10	c.	c.	PROPN
admet-547	303	11	bevan	bevan	PROPN
admet-547	303	12	,	,	PUNCT
admet-547	303	13	d.	d.	PROPN
admet-547	303	14	reynolds	reynolds	PROPN
admet-547	303	15	,	,	PUNCT
admet-547	303	16	m.	m.	PROPN
admet-547	303	17	abraham	abraham	PROPN
admet-547	303	18	.	.	PUNCT
admet-547	304	1	rapid	rapid	ADJ
admet-547	304	2	method	method	NOUN
admet-547	304	3	for	for	ADP
admet-547	304	4	the	the	DET
admet-547	304	5	estimation	estimation	NOUN
admet-547	304	6	of	of	ADP
admet-547	304	7	octanol	octanol	NOUN
admet-547	304	8	/	/	SYM
admet-547	304	9	water	water	NOUN
admet-547	304	10	partition	partition	NOUN
admet-547	304	11	coefficient	coefficient	NOUN
admet-547	304	12	(	(	PUNCT
admet-547	304	13	log	log	PROPN
admet-547	304	14	poct	poct	PROPN
admet-547	304	15	)	)	PUNCT
admet-547	304	16	from	from	ADP
admet-547	304	17	gradient	gradient	ADJ
admet-547	304	18	rp	rp	NOUN
admet-547	304	19	-	-	PUNCT
admet-547	304	20	hplc	hplc	NOUN
admet-547	304	21	retention	retention	NOUN
admet-547	304	22	and	and	CCONJ
admet-547	304	23	a	a	DET
admet-547	304	24	hydrogen	hydrogen	NOUN
admet-547	304	25	bond	bond	NOUN
admet-547	304	26	acidity	acidity	NOUN
admet-547	304	27	term	term	NOUN
admet-547	304	28	(	(	PUNCT
admet-547	304	29	sigma	sigma	NOUN
admet-547	304	30	alpha2h	alpha2h	ADV
admet-547	304	31	)	)	PUNCT
admet-547	304	32	.	.	PUNCT
admet-547	305	1	curr	curr	AUX
admet-547	305	2	.	.	PUNCT
admet-547	305	3	med	med	PROPN
admet-547	305	4	.	.	PROPN
admet-547	305	5	chem	chem	PROPN
admet-547	305	6	.	.	PUNCT
admet-547	306	1	8	8	NUM
admet-547	306	2	(	(	PUNCT
admet-547	306	3	2001	2001	NUM
admet-547	306	4	)	)	PUNCT
admet-547	306	5	1137–1146	1137–1146	NUM
admet-547	306	6	.	.	PUNCT
admet-547	307	1	[	[	X
admet-547	307	2	17	17	NUM
admet-547	307	3	]	]	X
admet-547	307	4	f.	f.	PROPN
admet-547	307	5	hollósy	hollósy	PROPN
admet-547	307	6	,	,	PUNCT
admet-547	307	7	k.	k.	PROPN
admet-547	307	8	valkó	valkó	PROPN
admet-547	307	9	,	,	PUNCT
admet-547	307	10	a.	a.	NOUN
admet-547	307	11	hersey	hersey	PROPN
admet-547	307	12	,	,	PUNCT
admet-547	307	13	s.	s.	PROPN
admet-547	307	14	nunhuck	nunhuck	PROPN
admet-547	307	15	,	,	PUNCT
admet-547	307	16	g.	g.	PROPN
admet-547	307	17	kéri	kéri	PROPN
admet-547	307	18	,	,	PUNCT
admet-547	307	19	c.	c.	PROPN
admet-547	307	20	bevan	bevan	PROPN
admet-547	307	21	.	.	PUNCT
admet-547	308	1	estimation	estimation	NOUN
admet-547	308	2	of	of	ADP
admet-547	308	3	volume	volume	NOUN
admet-547	308	4	of	of	ADP
admet-547	308	5	distribution	distribution	NOUN
admet-547	308	6	in	in	ADP
admet-547	308	7	humans	human	NOUN
admet-547	308	8	from	from	ADP
admet-547	308	9	high	high	ADJ
admet-547	308	10	throughput	throughput	NOUN
admet-547	308	11	hplc	hplc	NOUN
admet-547	308	12	-	-	PUNCT
admet-547	308	13	based	base	VERB
admet-547	308	14	measurements	measurement	NOUN
admet-547	308	15	of	of	ADP
admet-547	308	16	human	human	ADJ
admet-547	308	17	serum	serum	NOUN
admet-547	308	18	albumin	albumin	NOUN
admet-547	308	19	binding	bind	VERB
admet-547	308	20	and	and	CCONJ
admet-547	308	21	immobilized	immobilize	VERB
admet-547	308	22	artificial	artificial	ADJ
admet-547	308	23	membrane	membrane	NOUN
admet-547	308	24	partitioning	partitioning	NOUN
admet-547	308	25	.	.	PUNCT
admet-547	309	1	j.	j.	PROPN
admet-547	309	2	med	med	PROPN
admet-547	309	3	.	.	PROPN
admet-547	309	4	chem	chem	PROPN
admet-547	309	5	.	.	PUNCT
admet-547	310	1	49	49	NUM
admet-547	310	2	(	(	PUNCT
admet-547	310	3	2006	2006	NUM
admet-547	310	4	)	)	PUNCT
admet-547	310	5	6958–6971	6958–6971	NUM
admet-547	310	6	.	.	PUNCT
admet-547	311	1	[	[	X
admet-547	311	2	18	18	NUM
admet-547	311	3	]	]	PUNCT
admet-547	311	4	k.	k.	PROPN
admet-547	311	5	valko	valko	PROPN
admet-547	311	6	,	,	PUNCT
admet-547	311	7	s.	s.	PROPN
admet-547	311	8	nunhuck	nunhuck	PROPN
admet-547	311	9	,	,	PUNCT
admet-547	311	10	c.	c.	PROPN
admet-547	311	11	bevan	bevan	PROPN
admet-547	311	12	,	,	PUNCT
admet-547	311	13	m.h	m.h	PROPN
admet-547	311	14	.	.	PROPN
admet-547	311	15	abraham	abraham	PROPN
admet-547	311	16	,	,	PUNCT
admet-547	311	17	d.p	d.p	PROPN
admet-547	311	18	.	.	PROPN
admet-547	311	19	reynolds	reynolds	PROPN
admet-547	311	20	.	.	PUNCT
admet-547	312	1	fast	fast	ADJ
admet-547	312	2	gradient	gradient	NOUN
admet-547	312	3	hplc	hplc	NOUN
admet-547	312	4	method	method	NOUN
admet-547	312	5	to	to	PART
admet-547	312	6	determine	determine	VERB
admet-547	312	7	compounds	compound	NOUN
admet-547	312	8	binding	bind	VERB
admet-547	312	9	to	to	ADP
admet-547	312	10	human	human	ADJ
admet-547	312	11	serum	serum	NOUN
admet-547	312	12	albumin	albumin	NOUN
admet-547	312	13	.	.	PUNCT
admet-547	313	1	relationships	relationship	NOUN
admet-547	313	2	with	with	ADP
admet-547	313	3	octanol	octanol	NOUN
admet-547	313	4	/	/	SYM
admet-547	313	5	water	water	NOUN
admet-547	313	6	and	and	CCONJ
admet-547	313	7	immobilized	immobilize	VERB
admet-547	313	8	artificial	artificial	ADJ
admet-547	313	9	membrane	membrane	NOUN
admet-547	313	10	lipophilicity	lipophilicity	NOUN
admet-547	313	11	.	.	PUNCT
admet-547	314	1	j.	j.	PROPN
admet-547	314	2	pharm	pharm	PROPN
admet-547	314	3	.	.	PUNCT
admet-547	315	1	sci	sci	PROPN
admet-547	315	2	.	.	PROPN
admet-547	316	1	92	92	NUM
admet-547	316	2	(	(	PUNCT
admet-547	316	3	2003	2003	NUM
admet-547	316	4	)	)	PUNCT
admet-547	316	5	2236	2236	NUM
admet-547	316	6	-	-	SYM
admet-547	316	7	2248	2248	NUM
admet-547	316	8	.	.	PUNCT
admet-547	317	1	admet	admet	PROPN
admet-547	317	2	&	&	CCONJ
admet-547	317	3	dmpk	dmpk	PROPN
admet-547	317	4	6(2	6(2	NUM
admet-547	317	5	)	)	PUNCT
admet-547	317	6	(	(	PUNCT
admet-547	317	7	2018	2018	NUM
admet-547	317	8	)	)	PUNCT
admet-547	317	9	176	176	NUM
admet-547	317	10	-	-	SYM
admet-547	317	11	189	189	NUM
admet-547	317	12	in	in	ADP
admet-547	317	13	vitro	vitro	X
admet-547	317	14	and	and	CCONJ
admet-547	317	15	in	in	ADP
admet-547	317	16	vivo	vivo	ADJ
admet-547	317	17	characterization	characterization	NOUN
admet-547	317	18	of	of	ADP
admet-547	317	19	gm6	gm6	PROPN
admet-547	317	20	doi	doi	NOUN
admet-547	317	21	:	:	PUNCT
admet-547	317	22	10.5599	10.5599	NUM
admet-547	317	23	/	/	SYM
admet-547	317	24	admet.547	admet.547	NOUN
admet-547	317	25	189	189	NUM
admet-547	317	26	[	[	X
admet-547	317	27	19	19	NUM
admet-547	317	28	]	]	PUNCT
admet-547	317	29	k.	k.	PROPN
admet-547	317	30	valko	valko	PROPN
admet-547	317	31	.	.	PUNCT
admet-547	318	1	lipophilicity	lipophilicity	PROPN
admet-547	318	2	and	and	CCONJ
admet-547	318	3	biomimetic	biomimetic	ADJ
admet-547	318	4	properties	property	NOUN
admet-547	318	5	measured	measure	VERB
admet-547	318	6	by	by	ADP
admet-547	318	7	hplc	hplc	NOUN
admet-547	318	8	to	to	PART
admet-547	318	9	support	support	VERB
admet-547	318	10	drug	drug	NOUN
admet-547	318	11	discovery	discovery	NOUN
admet-547	318	12	.	.	PUNCT
admet-547	319	1	j.	j.	PROPN
admet-547	319	2	pharm	pharm	PROPN
admet-547	319	3	.	.	PUNCT
admet-547	319	4	biomed	biome	VERB
admet-547	319	5	.	.	PUNCT
admet-547	320	1	anal	anal	ADJ
admet-547	320	2	.	.	PUNCT
admet-547	321	1	130	130	NUM
admet-547	321	2	(	(	PUNCT
admet-547	321	3	2016	2016	NUM
admet-547	321	4	)	)	PUNCT
admet-547	321	5	35–54	35–54	NUM
admet-547	321	6	.	.	PUNCT
admet-547	322	1	[	[	X
admet-547	322	2	20	20	NUM
admet-547	322	3	]	]	X
admet-547	322	4	k.l	k.l	PROPN
admet-547	322	5	.	.	PROPN
admet-547	322	6	valkó	valkó	PROPN
admet-547	322	7	,	,	PUNCT
admet-547	322	8	s.b	s.b	PROPN
admet-547	322	9	.	.	PROPN
admet-547	322	10	nunhuck	nunhuck	PROPN
admet-547	322	11	,	,	PUNCT
admet-547	322	12	a.p	a.p	PROPN
admet-547	322	13	.	.	PROPN
admet-547	322	14	hill	hill	PROPN
admet-547	322	15	.	.	PUNCT
admet-547	323	1	estimating	estimate	VERB
admet-547	323	2	unbound	unbound	NOUN
admet-547	323	3	volume	volume	NOUN
admet-547	323	4	of	of	ADP
admet-547	323	5	distribution	distribution	NOUN
admet-547	323	6	and	and	CCONJ
admet-547	323	7	tissue	tissue	NOUN
admet-547	323	8	binding	bind	VERB
admet-547	323	9	by	by	ADP
admet-547	323	10	in	in	ADP
admet-547	323	11	vitro	vitro	X
admet-547	323	12	hplc	hplc	NOUN
admet-547	323	13	-	-	PUNCT
admet-547	323	14	based	base	VERB
admet-547	323	15	human	human	ADJ
admet-547	323	16	serum	serum	NOUN
admet-547	323	17	albumin	albumin	NOUN
admet-547	323	18	and	and	CCONJ
admet-547	323	19	immobilized	immobilize	VERB
admet-547	323	20	artificial	artificial	ADJ
admet-547	323	21	artificial	artificial	ADJ
admet-547	323	22	membrane	membrane	NOUN
admet-547	323	23	-	-	PUNCT
admet-547	323	24	binding	bind	VERB
admet-547	323	25	measurements	measurement	NOUN
admet-547	323	26	.	.	PUNCT
admet-547	324	1	j.	j.	PROPN
admet-547	324	2	pharm	pharm	PROPN
admet-547	324	3	.	.	PUNCT
admet-547	325	1	sci	sci	PROPN
admet-547	325	2	.	.	PROPN
admet-547	325	3	100	100	NUM
admet-547	325	4	(	(	PUNCT
admet-547	325	5	2011	2011	NUM
admet-547	325	6	)	)	PUNCT
admet-547	325	7	849–862	849–862	NUM
admet-547	325	8	.	.	PUNCT
admet-547	326	1	[	[	X
admet-547	326	2	21	21	NUM
admet-547	326	3	]	]	PUNCT
admet-547	326	4	k.	k.	PROPN
admet-547	326	5	valko	valko	PROPN
admet-547	326	6	,	,	PUNCT
admet-547	326	7	e.	e.	PROPN
admet-547	326	8	chiarparin	chiarparin	PROPN
admet-547	326	9	,	,	PUNCT
admet-547	326	10	s.	s.	PROPN
admet-547	326	11	nunhuck	nunhuck	PROPN
admet-547	326	12	,	,	PUNCT
admet-547	326	13	d.	d.	PROPN
admet-547	326	14	montanari	montanari	PROPN
admet-547	326	15	.	.	PUNCT
admet-547	327	1	in	in	ADP
admet-547	327	2	vitro	vitro	X
admet-547	327	3	measurement	measurement	NOUN
admet-547	327	4	of	of	ADP
admet-547	327	5	drug	drug	NOUN
admet-547	327	6	efficiency	efficiency	NOUN
admet-547	327	7	index	index	NOUN
admet-547	327	8	to	to	PART
admet-547	327	9	aid	aid	VERB
admet-547	327	10	early	early	ADJ
admet-547	327	11	lead	lead	ADJ
admet-547	327	12	optimization	optimization	NOUN
admet-547	327	13	.	.	PUNCT
admet-547	328	1	j.	j.	PROPN
admet-547	328	2	pharm	pharm	PROPN
admet-547	328	3	.	.	PUNCT
admet-547	329	1	sci	sci	PROPN
admet-547	329	2	.	.	PROPN
admet-547	330	1	101	101	NUM
admet-547	330	2	(	(	PUNCT
admet-547	330	3	2012	2012	NUM
admet-547	330	4	)	)	PUNCT
admet-547	330	5	4155	4155	NUM
admet-547	330	6	-	-	SYM
admet-547	330	7	4169	4169	NUM
admet-547	330	8	.	.	PUNCT
admet-547	331	1	[	[	X
admet-547	331	2	22	22	NUM
admet-547	331	3	]	]	PUNCT
admet-547	331	4	k.	k.	PROPN
admet-547	331	5	valko	valko	PROPN
admet-547	331	6	,	,	PUNCT
admet-547	331	7	physicochemical	physicochemical	ADJ
admet-547	331	8	and	and	CCONJ
admet-547	331	9	biomimetic	biomimetic	ADJ
admet-547	331	10	properties	property	NOUN
admet-547	331	11	in	in	ADP
admet-547	331	12	drug	drug	NOUN
admet-547	331	13	discovery	discovery	NOUN
admet-547	331	14	chromatographic	chromatographic	ADJ
admet-547	331	15	techniques	technique	NOUN
admet-547	331	16	for	for	ADP
admet-547	331	17	lead	lead	ADJ
admet-547	331	18	optimization	optimization	NOUN
admet-547	331	19	.	.	PUNCT
admet-547	332	1	wiley	wiley	PROPN
admet-547	332	2	,	,	PUNCT
admet-547	332	3	hoboken	hoboken	PROPN
admet-547	332	4	nj	nj	PROPN
admet-547	332	5	(	(	PUNCT
admet-547	332	6	2014	2014	NUM
admet-547	332	7	)	)	PUNCT
admet-547	332	8	.	.	PUNCT
admet-547	333	1	[	[	X
admet-547	333	2	23	23	NUM
admet-547	333	3	]	]	X
admet-547	333	4	l.j	l.j	PROPN
admet-547	333	5	.	.	PROPN
admet-547	333	6	gordon	gordon	PROPN
admet-547	333	7	,	,	PUNCT
admet-547	333	8	m.	m.	NOUN
admet-547	333	9	allen	allen	PROPN
admet-547	333	10	,	,	PUNCT
admet-547	333	11	p.	p.	PROPN
admet-547	333	12	artursson	artursson	PROPN
admet-547	333	13	,	,	PUNCT
admet-547	333	14	m.m	m.m	PROPN
admet-547	333	15	.	.	PROPN
admet-547	333	16	hann	hann	PROPN
admet-547	333	17	,	,	PUNCT
admet-547	333	18	b.j	b.j	PROPN
admet-547	333	19	.	.	PROPN
admet-547	333	20	leavens	leaven	VERB
admet-547	333	21	,	,	PUNCT
admet-547	333	22	a.	a.	NOUN
admet-547	333	23	mateus	mateus	PROPN
admet-547	333	24	,	,	PUNCT
admet-547	333	25	s.	s.	PROPN
admet-547	333	26	readshaw	readshaw	PROPN
admet-547	333	27	,	,	PUNCT
admet-547	333	28	k.	k.	PROPN
admet-547	333	29	valko	valko	PROPN
admet-547	333	30	,	,	PUNCT
admet-547	333	31	g.j	g.j	PROPN
admet-547	333	32	.	.	PROPN
admet-547	333	33	wayne	wayne	PROPN
admet-547	333	34	,	,	PUNCT
admet-547	333	35	a.	a.	PROPN
admet-547	333	36	west	west	PROPN
admet-547	333	37	.	.	PUNCT
admet-547	334	1	direct	direct	ADJ
admet-547	334	2	measurement	measurement	NOUN
admet-547	334	3	of	of	ADP
admet-547	334	4	intracellular	intracellular	ADJ
admet-547	334	5	compound	compound	NOUN
admet-547	334	6	concentration	concentration	NOUN
admet-547	334	7	by	by	ADP
admet-547	334	8	rapidfire	rapidfire	NOUN
admet-547	334	9	mass	mass	PROPN
admet-547	334	10	spectrometry	spectrometry	NOUN
admet-547	334	11	offers	offer	VERB
admet-547	334	12	insights	insight	NOUN
admet-547	334	13	into	into	ADP
admet-547	334	14	cell	cell	NOUN
admet-547	334	15	permeability	permeability	NOUN
admet-547	334	16	.	.	PUNCT
admet-547	335	1	j.	j.	PROPN
admet-547	335	2	biomol	biomol	PROPN
admet-547	335	3	.	.	PUNCT
admet-547	336	1	screen	screen	NOUN
admet-547	336	2	.	.	PUNCT
admet-547	337	1	21	21	NUM
admet-547	337	2	(	(	PUNCT
admet-547	337	3	2016	2016	NUM
admet-547	337	4	)	)	PUNCT
admet-547	337	5	156	156	NUM
admet-547	337	6	-	-	SYM
admet-547	337	7	164	164	NUM
admet-547	337	8	.	.	PUNCT
admet-547	338	1	[	[	X
admet-547	338	2	24	24	NUM
admet-547	338	3	]	]	SYM
admet-547	338	4	a.b	a.b	PROPN
admet-547	338	5	.	.	PROPN
admet-547	338	6	ahmad	ahmad	PROPN
admet-547	338	7	,	,	PUNCT
admet-547	338	8	p.n	p.n	PROPN
admet-547	338	9	.	.	PROPN
admet-547	338	10	bennett	bennett	PROPN
admet-547	338	11	,	,	PUNCT
admet-547	338	12	m.	m.	NOUN
admet-547	338	13	rowland	rowland	PROPN
admet-547	338	14	.	.	PUNCT
admet-547	339	1	models	model	NOUN
admet-547	339	2	of	of	ADP
admet-547	339	3	hepatic	hepatic	ADJ
admet-547	339	4	drug	drug	NOUN
admet-547	339	5	clearance	clearance	NOUN
admet-547	339	6	:	:	PUNCT
admet-547	339	7	discrimination	discrimination	NOUN
admet-547	339	8	between	between	ADP
admet-547	339	9	the	the	DET
admet-547	339	10	‘	'	PUNCT
admet-547	339	11	well	well	ADV
admet-547	339	12	stirred	stir	VERB
admet-547	339	13	’	'	PUNCT
admet-547	339	14	and	and	CCONJ
admet-547	339	15	‘	'	PUNCT
admet-547	339	16	parallel	parallel	ADJ
admet-547	339	17	-	-	PUNCT
admet-547	339	18	tube	tube	NOUN
admet-547	339	19	’	'	PUNCT
admet-547	339	20	models	model	NOUN
admet-547	339	21	.	.	PUNCT
admet-547	340	1	j.	j.	PROPN
admet-547	340	2	pharm	pharm	PROPN
admet-547	340	3	.	.	PUNCT
admet-547	341	1	pharmacol	pharmacol	PROPN
admet-547	341	2	.	.	PROPN
admet-547	342	1	35	35	NUM
admet-547	342	2	(	(	PUNCT
admet-547	342	3	1983	1983	NUM
admet-547	342	4	)	)	PUNCT
admet-547	342	5	219	219	NUM
admet-547	342	6	-	-	SYM
admet-547	342	7	224	224	NUM
admet-547	342	8	.	.	PUNCT
admet-547	343	1	[	[	X
admet-547	343	2	25	25	NUM
admet-547	343	3	]	]	PUNCT
admet-547	343	4	j.	j.	PROPN
admet-547	343	5	yu	yu	PROPN
admet-547	343	6	,	,	PUNCT
admet-547	343	7	h.	h.	PROPN
admet-547	343	8	zhu	zhu	PROPN
admet-547	343	9	,	,	PUNCT
admet-547	343	10	d.	d.	PROPN
admet-547	343	11	ko	ko	PROPN
admet-547	343	12	,	,	PUNCT
admet-547	343	13	m.s	m.s	PROPN
admet-547	343	14	.	.	PROPN
admet-547	343	15	kindy	kindy	PROPN
admet-547	343	16	.	.	PUNCT
admet-547	343	17	motoneuronotrophic	motoneuronotrophic	ADJ
admet-547	343	18	factor	factor	NOUN
admet-547	343	19	analog	analog	NOUN
admet-547	343	20	gm6	gm6	PROPN
admet-547	343	21	reduces	reduce	VERB
admet-547	343	22	infarct	infarct	ADJ
admet-547	343	23	volume	volume	NOUN
admet-547	343	24	and	and	CCONJ
admet-547	343	25	behavioral	behavioral	ADJ
admet-547	343	26	deficits	deficit	NOUN
admet-547	343	27	following	follow	VERB
admet-547	343	28	transient	transient	ADJ
admet-547	343	29	ischemia	ischemia	NOUN
admet-547	343	30	in	in	ADP
admet-547	343	31	the	the	DET
admet-547	343	32	mouse	mouse	NOUN
admet-547	343	33	.	.	PUNCT
admet-547	344	1	brain	brain	NOUN
admet-547	344	2	res	re	NOUN
admet-547	344	3	.	.	PUNCT
admet-547	344	4	1238	1238	NUM
admet-547	344	5	(	(	PUNCT
admet-547	344	6	2008	2008	NUM
admet-547	344	7	)	)	PUNCT
admet-547	345	1	143–153	143–153	NUM
admet-547	345	2	.	.	PUNCT
admet-547	346	1	[	[	X
admet-547	346	2	26	26	NUM
admet-547	346	3	]	]	X
admet-547	346	4	s.	s.	PROPN
admet-547	346	5	braggio	braggio	PROPN
admet-547	346	6	,	,	PUNCT
admet-547	346	7	d.	d.	PROPN
admet-547	346	8	montanari	montanari	PROPN
admet-547	346	9	,	,	PUNCT
admet-547	346	10	t.	t.	PROPN
admet-547	346	11	rossi	rossi	PROPN
admet-547	346	12	,	,	PUNCT
admet-547	346	13	e.	e.	PROPN
admet-547	346	14	ratti	ratti	PROPN
admet-547	346	15	.	.	PUNCT
admet-547	346	16	drug	drug	NOUN
admet-547	346	17	efficiency	efficiency	NOUN
admet-547	346	18	:	:	PUNCT
admet-547	346	19	a	a	DET
admet-547	346	20	new	new	ADJ
admet-547	346	21	concept	concept	NOUN
admet-547	346	22	to	to	PART
admet-547	346	23	guide	guide	VERB
admet-547	346	24	lead	lead	ADJ
admet-547	346	25	optimization	optimization	NOUN
admet-547	346	26	programs	program	NOUN
admet-547	346	27	towards	towards	ADP
admet-547	346	28	the	the	DET
admet-547	346	29	selection	selection	NOUN
admet-547	346	30	of	of	ADP
admet-547	346	31	better	well	ADJ
admet-547	346	32	clinical	clinical	ADJ
admet-547	346	33	candidates	candidate	NOUN
admet-547	346	34	.	.	PUNCT
admet-547	347	1	expert	expert	NOUN
admet-547	347	2	opin	opin	NOUN
admet-547	347	3	.	.	PUNCT
admet-547	348	1	drug	drug	NOUN
admet-547	348	2	discov	discov	NOUN
admet-547	348	3	.	.	PUNCT
admet-547	349	1	5	5	NUM
admet-547	349	2	(	(	PUNCT
admet-547	349	3	2010	2010	NUM
admet-547	349	4	)	)	PUNCT
admet-547	349	5	609	609	NUM
admet-547	349	6	–	–	PUNCT
admet-547	349	7	618	618	NUM
admet-547	349	8	.	.	PUNCT
admet-547	350	1	[	[	X
admet-547	350	2	27	27	NUM
admet-547	350	3	]	]	X
admet-547	350	4	l.	l.	PROPN
admet-547	350	5	di	di	PROPN
admet-547	350	6	.	.	PROPN
admet-547	350	7	strategic	strategic	ADJ
admet-547	350	8	approaches	approach	NOUN
admet-547	350	9	to	to	ADP
admet-547	350	10	optimizing	optimize	VERB
admet-547	350	11	peptide	peptide	NOUN
admet-547	350	12	adme	adme	NOUN
admet-547	350	13	properties	property	NOUN
admet-547	350	14	.	.	PUNCT
admet-547	351	1	aaps	aaps	PROPN
admet-547	351	2	j.	j.	PROPN
admet-547	351	3	17	17	NUM
admet-547	351	4	(	(	PUNCT
admet-547	351	5	2015	2015	NUM
admet-547	351	6	)	)	PUNCT
admet-547	351	7	134	134	NUM
admet-547	351	8	-	-	SYM
admet-547	351	9	143	143	NUM
admet-547	351	10	.	.	PUNCT
admet-547	352	1	[	[	X
admet-547	352	2	28	28	NUM
admet-547	352	3	]	]	X
admet-547	352	4	w.	w.	PROPN
admet-547	352	5	li	li	PROPN
admet-547	352	6	,	,	PUNCT
admet-547	352	7	j.	j.	PROPN
admet-547	352	8	zhang	zhang	PROPN
admet-547	352	9	,	,	PUNCT
admet-547	352	10	f.l	f.l	PROPN
admet-547	352	11	.	.	PROPN
admet-547	352	12	tse	tse	PROPN
admet-547	352	13	.	.	PUNCT
admet-547	352	14	strategies	strategy	NOUN
admet-547	352	15	in	in	ADP
admet-547	352	16	quantitative	quantitative	ADJ
admet-547	352	17	lc‐ms	lc‐ms	AUX
admet-547	352	18	/	/	SYM
admet-547	353	1	ms	ms	NOUN
admet-547	353	2	analysis	analysis	NOUN
admet-547	353	3	of	of	ADP
admet-547	353	4	unstable	unstable	ADJ
admet-547	353	5	small	small	ADJ
admet-547	353	6	molecules	molecule	NOUN
admet-547	353	7	in	in	ADP
admet-547	353	8	biological	biological	ADJ
admet-547	353	9	matrices	matrix	NOUN
admet-547	353	10	.	.	PUNCT
admet-547	353	11	biomed	biome	VERB
admet-547	353	12	.	.	PUNCT
admet-547	354	1	chromatogr	chromatogr	PROPN
admet-547	354	2	.	.	PUNCT
admet-547	355	1	25	25	NUM
admet-547	355	2	(	(	PUNCT
admet-547	355	3	2011	2011	NUM
admet-547	355	4	)	)	PUNCT
admet-547	356	1	258–277	258–277	NUM
admet-547	356	2	.	.	PUNCT
admet-547	357	1	[	[	X
admet-547	357	2	29	29	NUM
admet-547	357	3	]	]	X
admet-547	357	4	l.t	l.t	PROPN
admet-547	357	5	.	.	PROPN
admet-547	357	6	nguyen	nguyen	PROPN
admet-547	357	7	,	,	PUNCT
admet-547	357	8	j.k	j.k	PROPN
admet-547	357	9	.	.	PROPN
admet-547	357	10	chau	chau	PROPN
admet-547	357	11	,	,	PUNCT
admet-547	357	12	n.a	n.a	PROPN
admet-547	357	13	.	.	PROPN
admet-547	357	14	perry	perry	PROPN
admet-547	357	15	,	,	PUNCT
admet-547	357	16	l.	l.	PROPN
admet-547	357	17	de	de	PROPN
admet-547	357	18	boer	boer	PROPN
admet-547	357	19	,	,	PUNCT
admet-547	357	20	s.a	s.a	PROPN
admet-547	357	21	.	.	PROPN
admet-547	357	22	j.	j.	PROPN
admet-547	357	23	zaat	zaat	PROPN
admet-547	357	24	,	,	PUNCT
admet-547	357	25	h.j	h.j	PROPN
admet-547	357	26	.	.	PROPN
admet-547	357	27	vogel	vogel	PROPN
admet-547	357	28	.	.	PUNCT
admet-547	358	1	serum	serum	NOUN
admet-547	358	2	stabilities	stability	NOUN
admet-547	358	3	of	of	ADP
admet-547	358	4	short	short	ADJ
admet-547	358	5	tryptophanand	tryptophanand	NOUN
admet-547	358	6	arginine	arginine	NOUN
admet-547	358	7	-	-	PUNCT
admet-547	358	8	rich	rich	ADJ
admet-547	358	9	antimicrobial	antimicrobial	ADJ
admet-547	358	10	peptide	peptide	NOUN
admet-547	358	11	analogs	analog	NOUN
admet-547	358	12	.	.	PUNCT
admet-547	359	1	plos	plos	PROPN
admet-547	359	2	one	one	NUM
admet-547	359	3	5	5	NUM
admet-547	359	4	(	(	PUNCT
admet-547	359	5	2010	2010	NUM
admet-547	359	6	)	)	PUNCT
admet-547	359	7	1–8	1–8	X
admet-547	359	8	.	.	PUNCT
admet-547	360	1	[	[	X
admet-547	360	2	30	30	NUM
admet-547	360	3	]	]	X
admet-547	360	4	h.	h.	PROPN
admet-547	360	5	hui	hui	PROPN
admet-547	360	6	,	,	PUNCT
admet-547	360	7	l.	l.	PROPN
admet-547	360	8	farilla	farilla	PROPN
admet-547	360	9	,	,	PUNCT
admet-547	360	10	p.	p.	PROPN
admet-547	360	11	merkel	merkel	PROPN
admet-547	360	12	,	,	PUNCT
admet-547	360	13	r.	r.	PROPN
admet-547	360	14	perfetti	perfetti	PROPN
admet-547	360	15	.	.	PUNCT
admet-547	361	1	the	the	DET
admet-547	361	2	short	short	ADJ
admet-547	361	3	half	half	ADJ
admet-547	361	4	-	-	PUNCT
admet-547	361	5	life	life	NOUN
admet-547	361	6	of	of	ADP
admet-547	361	7	glucagon	glucagon	NOUN
admet-547	361	8	-	-	PUNCT
admet-547	361	9	like	like	ADJ
admet-547	361	10	peptide-1	peptide-1	NOUN
admet-547	361	11	in	in	ADP
admet-547	361	12	plasma	plasma	NOUN
admet-547	361	13	does	do	AUX
admet-547	361	14	not	not	PART
admet-547	361	15	reflect	reflect	VERB
admet-547	361	16	its	its	PRON
admet-547	361	17	long	long	ADV
admet-547	361	18	lasting	last	VERB
admet-547	361	19	beneficial	beneficial	ADJ
admet-547	361	20	effects	effect	NOUN
admet-547	361	21	.	.	PUNCT
admet-547	362	1	eur	eur	PROPN
admet-547	362	2	.	.	PUNCT
admet-547	363	1	j.	j.	PROPN
admet-547	363	2	endocrinol	endocrinol	PROPN
admet-547	363	3	.	.	PUNCT
admet-547	364	1	146	146	NUM
admet-547	364	2	(	(	PUNCT
admet-547	364	3	2002	2002	NUM
admet-547	364	4	)	)	PUNCT
admet-547	365	1	863–869	863–869	NUM
admet-547	365	2	.	.	PUNCT
admet-547	366	1	[	[	X
admet-547	366	2	31	31	NUM
admet-547	366	3	]	]	X
admet-547	366	4	n.	n.	NOUN
admet-547	366	5	tsomaia	tsomaia	PROPN
admet-547	366	6	.	.	PUNCT
admet-547	367	1	peptide	peptide	NOUN
admet-547	367	2	therapeutics	therapeutic	NOUN
admet-547	367	3	:	:	PUNCT
admet-547	367	4	targeting	target	VERB
admet-547	367	5	the	the	DET
admet-547	367	6	undruggable	undruggable	ADJ
admet-547	367	7	space	space	NOUN
admet-547	367	8	.	.	PUNCT
admet-547	368	1	eur	eur	PROPN
admet-547	368	2	.	.	PUNCT
admet-547	369	1	j.	j.	PROPN
admet-547	369	2	med	med	PROPN
admet-547	369	3	.	.	PROPN
admet-547	369	4	chem	chem	PROPN
admet-547	369	5	.	.	PUNCT
admet-547	370	1	94	94	NUM
admet-547	370	2	(	(	PUNCT
admet-547	370	3	2015	2015	NUM
admet-547	370	4	)	)	PUNCT
admet-547	371	1	459–470	459–470	NUM
admet-547	371	2	.	.	PUNCT
admet-547	372	1	[	[	X
admet-547	372	2	32	32	NUM
admet-547	372	3	]	]	SYM
admet-547	372	4	center	center	NOUN
admet-547	372	5	for	for	ADP
admet-547	372	6	drug	drug	NOUN
admet-547	372	7	evaluation	evaluation	NOUN
admet-547	372	8	and	and	CCONJ
admet-547	372	9	research	research	NOUN
admet-547	372	10	.	.	PUNCT
admet-547	373	1	guidance	guidance	NOUN
admet-547	373	2	for	for	ADP
admet-547	373	3	industry	industry	NOUN
admet-547	373	4	:	:	PUNCT
admet-547	373	5	estimating	estimate	VERB
admet-547	373	6	the	the	DET
admet-547	373	7	maximum	maximum	ADJ
admet-547	373	8	safe	safe	ADJ
admet-547	373	9	starting	starting	NOUN
admet-547	373	10	dose	dose	VERB
admet-547	373	11	in	in	ADP
admet-547	373	12	initial	initial	ADJ
admet-547	373	13	clinical	clinical	ADJ
admet-547	373	14	trials	trial	NOUN
admet-547	373	15	for	for	ADP
admet-547	373	16	therapeutics	therapeutic	NOUN
admet-547	373	17	in	in	ADP
admet-547	373	18	adult	adult	NOUN
admet-547	373	19	healthy	healthy	ADJ
admet-547	373	20	volunteers	volunteer	NOUN
admet-547	373	21	.	.	PUNCT
admet-547	374	1	us	us	PROPN
admet-547	374	2	dep	dep	PROPN
admet-547	374	3	.	.	PUNCT
admet-547	374	4	heal	heal	NOUN
admet-547	374	5	.	.	PUNCT
admet-547	375	1	hum	hum	ADJ
admet-547	375	2	.	.	PUNCT
admet-547	376	1	serv	serv	X
admet-547	376	2	.	.	PUNCT
admet-547	377	1	(	(	PUNCT
admet-547	377	2	2005	2005	NUM
admet-547	377	3	)	)	PUNCT
admet-547	377	4	1–27	1–27	NOUN
admet-547	377	5	.	.	PUNCT
admet-547	378	1	[	[	X
admet-547	378	2	33	33	NUM
admet-547	378	3	]	]	X
admet-547	378	4	d.f	d.f	PROPN
admet-547	378	5	.	.	PROPN
admet-547	378	6	mcginnity	mcginnity	PROPN
admet-547	378	7	,	,	PUNCT
admet-547	378	8	j.	j.	PROPN
admet-547	378	9	collington	collington	PROPN
admet-547	378	10	,	,	PUNCT
admet-547	378	11	r.p	r.p	PROPN
admet-547	378	12	.	.	PROPN
admet-547	378	13	austin	austin	PROPN
admet-547	378	14	,	,	PUNCT
admet-547	378	15	r.j	r.j	PROPN
admet-547	378	16	.	.	PROPN
admet-547	378	17	riley	riley	PROPN
admet-547	378	18	.	.	PUNCT
admet-547	379	1	evaluation	evaluation	NOUN
admet-547	379	2	of	of	ADP
admet-547	379	3	human	human	ADJ
admet-547	379	4	pharmacokinetics	pharmacokinetic	NOUN
admet-547	379	5	,	,	PUNCT
admet-547	379	6	therapeutic	therapeutic	ADJ
admet-547	379	7	dose	dose	NOUN
admet-547	379	8	and	and	CCONJ
admet-547	379	9	exposure	exposure	NOUN
admet-547	379	10	predictions	prediction	NOUN
admet-547	379	11	using	use	VERB
admet-547	379	12	marketed	market	VERB
admet-547	379	13	oral	oral	ADJ
admet-547	379	14	drugs	drug	NOUN
admet-547	379	15	.	.	PUNCT
admet-547	380	1	curr	curr	PROPN
admet-547	380	2	.	.	PUNCT
admet-547	380	3	drug	drug	NOUN
admet-547	380	4	metabol	metabol	NOUN
admet-547	380	5	.	.	PUNCT
admet-547	381	1	8	8	NUM
admet-547	381	2	(	(	PUNCT
admet-547	381	3	2007	2007	NUM
admet-547	381	4	)	)	PUNCT
admet-547	381	5	463	463	NUM
admet-547	381	6	-	-	SYM
admet-547	381	7	479	479	NUM
admet-547	381	8	.	.	PUNCT
admet-547	382	1	[	[	X
admet-547	382	2	34	34	NUM
admet-547	382	3	]	]	X
admet-547	382	4	e.	e.	PROPN
admet-547	382	5	ezan	ezan	PROPN
admet-547	382	6	.	.	PUNCT
admet-547	383	1	pharmacokinetic	pharmacokinetic	ADJ
admet-547	383	2	studies	study	NOUN
admet-547	383	3	of	of	ADP
admet-547	383	4	protein	protein	NOUN
admet-547	383	5	drugs	drug	NOUN
admet-547	383	6	:	:	PUNCT
admet-547	383	7	past	past	ADJ
admet-547	383	8	,	,	PUNCT
admet-547	383	9	present	present	ADJ
admet-547	383	10	and	and	CCONJ
admet-547	383	11	future	future	NOUN
admet-547	383	12	.	.	PUNCT
admet-547	384	1	adv	adv	PROPN
admet-547	384	2	.	.	PUNCT
admet-547	384	3	drug	drug	PROPN
admet-547	384	4	deliv	deliv	PROPN
admet-547	384	5	.	.	PUNCT
admet-547	385	1	rev	rev	PROPN
admet-547	385	2	.	.	PROPN
admet-547	386	1	65	65	NUM
admet-547	386	2	(	(	PUNCT
admet-547	386	3	2013	2013	NUM
admet-547	386	4	)	)	PUNCT
admet-547	386	5	1065–1073	1065–1073	NUM
admet-547	386	6	.	.	PUNCT
admet-547	387	1	©	©	PROPN
admet-547	387	2	2018	2018	NUM
admet-547	387	3	by	by	ADP
admet-547	387	4	the	the	DET
admet-547	387	5	authors	author	NOUN
admet-547	387	6	;	;	PUNCT
admet-547	388	1	licensee	licensee	PROPN
admet-547	388	2	iapc	iapc	PROPN
admet-547	388	3	,	,	PUNCT
admet-547	388	4	zagreb	zagreb	PROPN
admet-547	388	5	,	,	PUNCT
admet-547	388	6	croatia	croatia	PROPN
admet-547	388	7	.	.	PUNCT
admet-547	389	1	this	this	DET
admet-547	389	2	article	article	NOUN
admet-547	389	3	is	be	AUX
admet-547	389	4	an	an	DET
admet-547	389	5	open	open	ADJ
admet-547	389	6	-	-	PUNCT
admet-547	389	7	access	access	NOUN
admet-547	389	8	article	article	NOUN
admet-547	389	9	distributed	distribute	VERB
admet-547	389	10	under	under	ADP
admet-547	389	11	the	the	DET
admet-547	389	12	terms	term	NOUN
admet-547	389	13	and	and	CCONJ
admet-547	389	14	conditions	condition	NOUN
admet-547	389	15	of	of	ADP
admet-547	389	16	the	the	DET
admet-547	389	17	creative	creative	ADJ
admet-547	389	18	commons	common	NOUN
admet-547	389	19	attribution	attribution	NOUN
admet-547	389	20	license	license	NOUN
admet-547	389	21	(	(	PUNCT
admet-547	389	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-547	389	23	)	)	PUNCT
admet-547	389	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN