id	sid	tid	token	lemma	pos
admet-553	1	1	immobilized	immobilize	VERB
admet-553	1	2	artificial	artificial	ADJ
admet-553	1	3	membrane	membrane	NOUN
admet-553	1	4	chromatography	chromatography	NOUN
admet-553	1	5	:	:	PUNCT
admet-553	1	6	from	from	ADP
admet-553	1	7	medicinal	medicinal	ADJ
admet-553	1	8	chemistry	chemistry	NOUN
admet-553	1	9	to	to	ADP
admet-553	1	10	environmental	environmental	ADJ
admet-553	1	11	sciences	science	NOUN
admet-553	1	12	doi	doi	NOUN
admet-553	1	13	:	:	PUNCT
admet-553	1	14	10.5599	10.5599	NUM
admet-553	1	15	/	/	SYM
admet-553	1	16	admet.553	admet.553	NOUN
admet-553	1	17	225	225	NUM
admet-553	1	18	admet	admet	X
admet-553	1	19	&	&	CCONJ
admet-553	1	20	dmpk	dmpk	PROPN
admet-553	1	21	6(3	6(3	PROPN
admet-553	1	22	)	)	PUNCT
admet-553	1	23	(	(	PUNCT
admet-553	1	24	2018	2018	NUM
admet-553	1	25	)	)	PUNCT
admet-553	1	26	225	225	NUM
admet-553	1	27	-	-	SYM
admet-553	1	28	241	241	NUM
admet-553	1	29	;	;	PUNCT
admet-553	1	30	doi	doi	NOUN
admet-553	1	31	:	:	PUNCT
admet-553	1	32	http://dx.doi.org/10.5599/admet.553	http://dx.doi.org/10.5599/admet.553	X
admet-553	1	33	open	open	ADJ
admet-553	1	34	access	access	NOUN
admet-553	1	35	:	:	PUNCT
admet-553	1	36	issn	issn	PROPN
admet-553	1	37	:	:	PUNCT
admet-553	1	38	1848	1848	NUM
admet-553	1	39	-	-	SYM
admet-553	1	40	7718	7718	NUM
admet-553	1	41	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-553	1	42	review	review	NOUN
admet-553	1	43	immobilized	immobilize	VERB
admet-553	1	44	artificial	artificial	ADJ
admet-553	1	45	membrane	membrane	NOUN
admet-553	1	46	chromatography	chromatography	NOUN
admet-553	1	47	:	:	PUNCT
admet-553	1	48	from	from	ADP
admet-553	1	49	medicinal	medicinal	ADJ
admet-553	1	50	chemistry	chemistry	NOUN
admet-553	1	51	to	to	ADP
admet-553	1	52	environmental	environmental	ADJ
admet-553	1	53	sciences	science	NOUN
admet-553	1	54	fotios	fotio	NOUN
admet-553	1	55	tsopelas1	tsopelas1	PROPN
admet-553	1	56	*	*	PROPN
admet-553	1	57	,	,	PUNCT
admet-553	1	58	chrysanthos	chrysanthos	PROPN
admet-553	1	59	stergiopoulos1	stergiopoulos1	PROPN
admet-553	1	60	and	and	CCONJ
admet-553	1	61	anna	anna	PROPN
admet-553	1	62	tsantili	tsantili	PROPN
admet-553	1	63	-	-	PUNCT
admet-553	1	64	kakoulidou2	kakoulidou2	NOUN
admet-553	1	65	1	1	NUM
admet-553	1	66	laboratory	laboratory	NOUN
admet-553	1	67	of	of	ADP
admet-553	1	68	inorganic	inorganic	ADJ
admet-553	1	69	and	and	CCONJ
admet-553	1	70	analytical	analytical	ADJ
admet-553	1	71	chemistry	chemistry	NOUN
admet-553	1	72	,	,	PUNCT
admet-553	1	73	school	school	NOUN
admet-553	1	74	of	of	ADP
admet-553	1	75	chemical	chemical	PROPN
admet-553	1	76	engineering	engineering	NOUN
admet-553	1	77	,	,	PUNCT
admet-553	1	78	national	national	PROPN
admet-553	1	79	technical	technical	PROPN
admet-553	1	80	university	university	PROPN
admet-553	1	81	of	of	ADP
admet-553	1	82	athens	athens	PROPN
admet-553	1	83	,	,	PUNCT
admet-553	1	84	iroon	iroon	NOUN
admet-553	1	85	polytechniou	polytechniou	NOUN
admet-553	1	86	9	9	NUM
admet-553	1	87	,	,	PUNCT
admet-553	1	88	157	157	NUM
admet-553	1	89	80	80	NUM
admet-553	1	90	athens	athens	PROPN
admet-553	1	91	,	,	PUNCT
admet-553	1	92	greece	greece	PROPN
admet-553	1	93	.	.	PROPN
admet-553	2	1	2	2	NUM
admet-553	2	2	laboratory	laboratory	NOUN
admet-553	2	3	of	of	ADP
admet-553	2	4	pharmaceutical	pharmaceutical	ADJ
admet-553	2	5	chemistry	chemistry	NOUN
admet-553	2	6	,	,	PUNCT
admet-553	2	7	school	school	NOUN
admet-553	2	8	of	of	ADP
admet-553	2	9	pharmacy	pharmacy	NOUN
admet-553	2	10	,	,	PUNCT
admet-553	2	11	university	university	NOUN
admet-553	2	12	of	of	ADP
admet-553	2	13	athens	athens	PROPN
admet-553	2	14	,	,	PUNCT
admet-553	2	15	panepistimiopolis	panepistimiopolis	PROPN
admet-553	2	16	,	,	PUNCT
admet-553	2	17	zografou	zografou	PROPN
admet-553	2	18	,	,	PUNCT
admet-553	2	19	157	157	NUM
admet-553	2	20	71	71	NUM
admet-553	2	21	athens	athen	NOUN
admet-553	2	22	,	,	PUNCT
admet-553	2	23	greece	greece	PROPN
admet-553	2	24	.	.	PUNCT
admet-553	3	1	*	*	PUNCT
admet-553	3	2	corresponding	correspond	VERB
admet-553	3	3	author	author	NOUN
admet-553	3	4	:	:	PUNCT
admet-553	3	5	e	e	NOUN
admet-553	3	6	-	-	NOUN
admet-553	3	7	mail	mail	NOUN
admet-553	3	8	:	:	PUNCT
admet-553	3	9	ftsop@central.ntua.gr	ftsop@central.ntua.gr	ADJ
admet-553	3	10	phone	phone	NOUN
admet-553	3	11	:	:	PUNCT
admet-553	3	12	+30	+30	NUM
admet-553	3	13	210	210	NUM
admet-553	3	14	7724022	7724022	NUM
admet-553	3	15	,	,	PUNCT
admet-553	3	16	+30	+30	NOUN
admet-553	3	17	210	210	NUM
admet-553	3	18	7723210	7723210	NUM
admet-553	3	19	received	receive	VERB
admet-553	3	20	:	:	PUNCT
admet-553	3	21	may	may	AUX
admet-553	3	22	21	21	NUM
admet-553	3	23	,	,	PUNCT
admet-553	3	24	2018	2018	NUM
admet-553	3	25	;	;	PUNCT
admet-553	3	26	revised	revise	VERB
admet-553	3	27	:	:	PUNCT
admet-553	3	28	august	august	PROPN
admet-553	3	29	15	15	NUM
admet-553	3	30	,	,	PUNCT
admet-553	3	31	2018	2018	NUM
admet-553	3	32	;	;	PUNCT
admet-553	3	33	available	available	ADJ
admet-553	3	34	online	online	NOUN
admet-553	3	35	:	:	PUNCT
admet-553	3	36	september	september	PROPN
admet-553	3	37	22	22	NUM
admet-553	3	38	,	,	PUNCT
admet-553	3	39	2018	2018	NUM
admet-553	3	40	abstract	abstract	ADJ
admet-553	3	41	immobilized	immobilize	VERB
admet-553	3	42	artificial	artificial	ADJ
admet-553	3	43	membrane	membrane	NOUN
admet-553	3	44	(	(	PUNCT
admet-553	3	45	iam	iam	PROPN
admet-553	3	46	)	)	PUNCT
admet-553	3	47	chromatography	chromatography	NOUN
admet-553	3	48	constitutes	constitute	VERB
admet-553	3	49	a	a	DET
admet-553	3	50	valuable	valuable	ADJ
admet-553	3	51	tool	tool	NOUN
admet-553	3	52	for	for	ADP
admet-553	3	53	medicinal	medicinal	ADJ
admet-553	3	54	chemists	chemist	NOUN
admet-553	3	55	to	to	PART
admet-553	3	56	prioritize	prioritize	VERB
admet-553	3	57	drug	drug	NOUN
admet-553	3	58	candidates	candidate	NOUN
admet-553	3	59	in	in	ADP
admet-553	3	60	early	early	ADJ
admet-553	3	61	drug	drug	NOUN
admet-553	3	62	development	development	NOUN
admet-553	3	63	.	.	PUNCT
admet-553	4	1	the	the	DET
admet-553	4	2	retention	retention	NOUN
admet-553	4	3	on	on	ADP
admet-553	4	4	iam	iam	PROPN
admet-553	4	5	stationary	stationary	ADJ
admet-553	4	6	phases	phase	NOUN
admet-553	4	7	encodes	encodes	PRON
admet-553	4	8	lipophilicity	lipophilicity	NOUN
admet-553	4	9	,	,	PUNCT
admet-553	4	10	electrostatic	electrostatic	ADJ
admet-553	4	11	and	and	CCONJ
admet-553	4	12	other	other	ADJ
admet-553	4	13	secondary	secondary	ADJ
admet-553	4	14	interactions	interaction	NOUN
admet-553	4	15	contrary	contrary	ADJ
admet-553	4	16	to	to	ADP
admet-553	4	17	traditional	traditional	ADJ
admet-553	4	18	octanol	octanol	NOUN
admet-553	4	19	-	-	PUNCT
admet-553	4	20	water	water	NOUN
admet-553	4	21	partitioning	partitioning	NOUN
admet-553	4	22	.	.	PUNCT
admet-553	5	1	an	an	DET
admet-553	5	2	increasing	increase	VERB
admet-553	5	3	number	number	NOUN
admet-553	5	4	of	of	ADP
admet-553	5	5	publications	publication	NOUN
admet-553	5	6	in	in	ADP
admet-553	5	7	recent	recent	ADJ
admet-553	5	8	years	year	NOUN
admet-553	5	9	have	have	AUX
admet-553	5	10	suggested	suggest	VERB
admet-553	5	11	that	that	SCONJ
admet-553	5	12	iam	iam	PROPN
admet-553	5	13	indices	index	NOUN
admet-553	5	14	,	,	PUNCT
admet-553	5	15	including	include	VERB
admet-553	5	16	isocratic	isocratic	ADJ
admet-553	5	17	log	log	NOUN
admet-553	5	18	k(iam	k(iam	PROPN
admet-553	5	19	)	)	PUNCT
admet-553	5	20	or	or	CCONJ
admet-553	5	21	extrapolated	extrapolate	VERB
admet-553	5	22	log	log	NOUN
admet-553	5	23	kw(iam	kw(iam	NOUN
admet-553	5	24	)	)	PUNCT
admet-553	5	25	retention	retention	NOUN
admet-553	5	26	factors	factor	NOUN
admet-553	5	27	,	,	PUNCT
admet-553	5	28	chromatographic	chromatographic	ADJ
admet-553	5	29	hydrophobicity	hydrophobicity	NOUN
admet-553	5	30	index	index	NOUN
admet-553	5	31	chi(iam	chi(iam	NOUN
admet-553	5	32	)	)	PUNCT
admet-553	5	33	or	or	CCONJ
admet-553	5	34	the	the	DET
admet-553	5	35	polarity	polarity	NOUN
admet-553	5	36	parameter	parameter	NOUN
admet-553	5	37	δlog	δlog	PROPN
admet-553	5	38	kw(iam	kw(iam	PROPN
admet-553	5	39	)	)	PUNCT
admet-553	5	40	can	can	AUX
admet-553	5	41	successfully	successfully	ADV
admet-553	5	42	model	model	VERB
admet-553	5	43	the	the	DET
admet-553	5	44	passage	passage	NOUN
admet-553	5	45	of	of	ADP
admet-553	5	46	xeniobiotics	xeniobiotic	NOUN
admet-553	5	47	through	through	ADP
admet-553	5	48	biological	biological	ADJ
admet-553	5	49	membranes	membrane	NOUN
admet-553	5	50	and	and	CCONJ
admet-553	5	51	barriers	barrier	NOUN
admet-553	5	52	and	and	CCONJ
admet-553	5	53	predict	predict	VERB
admet-553	5	54	pharmacokinetic	pharmacokinetic	ADJ
admet-553	5	55	properties	property	NOUN
admet-553	5	56	,	,	PUNCT
admet-553	5	57	often	often	ADV
admet-553	5	58	in	in	ADP
admet-553	5	59	combination	combination	NOUN
admet-553	5	60	with	with	ADP
admet-553	5	61	additional	additional	ADJ
admet-553	5	62	descriptors	descriptor	NOUN
admet-553	5	63	.	.	PUNCT
admet-553	6	1	examples	example	NOUN
admet-553	6	2	referring	refer	VERB
admet-553	6	3	to	to	ADP
admet-553	6	4	the	the	DET
admet-553	6	5	modeling	modeling	NOUN
admet-553	6	6	of	of	ADP
admet-553	6	7	human	human	ADJ
admet-553	6	8	oral	oral	ADJ
admet-553	6	9	absorption	absorption	NOUN
admet-553	6	10	,	,	PUNCT
admet-553	6	11	blood	blood	NOUN
admet-553	6	12	-	-	PUNCT
admet-553	6	13	brain	brain	NOUN
admet-553	6	14	penetration	penetration	NOUN
admet-553	6	15	and	and	CCONJ
admet-553	6	16	skin	skin	NOUN
admet-553	6	17	partition	partition	NOUN
admet-553	6	18	are	be	AUX
admet-553	6	19	described	describe	VERB
admet-553	6	20	.	.	PUNCT
admet-553	7	1	more	more	ADV
admet-553	7	2	recently	recently	ADV
admet-553	7	3	,	,	PUNCT
admet-553	7	4	iam	iam	PROPN
admet-553	7	5	chromatography	chromatography	NOUN
admet-553	7	6	has	have	AUX
admet-553	7	7	been	be	AUX
admet-553	7	8	applied	apply	VERB
admet-553	7	9	to	to	PART
admet-553	7	10	estimate	estimate	VERB
admet-553	7	11	toxicological	toxicological	ADJ
admet-553	7	12	endpoints	endpoint	NOUN
admet-553	7	13	in	in	ADP
admet-553	7	14	regard	regard	NOUN
admet-553	7	15	to	to	ADP
admet-553	7	16	drug	drug	NOUN
admet-553	7	17	safety	safety	NOUN
admet-553	7	18	,	,	PUNCT
admet-553	7	19	such	such	ADJ
admet-553	7	20	as	as	ADP
admet-553	7	21	phospholipidosis	phospholipidosis	NOUN
admet-553	7	22	potential	potential	NOUN
admet-553	7	23	,	,	PUNCT
admet-553	7	24	or	or	CCONJ
admet-553	7	25	in	in	ADP
admet-553	7	26	regard	regard	NOUN
admet-553	7	27	to	to	ADP
admet-553	7	28	chemical	chemical	ADJ
admet-553	7	29	risk	risk	NOUN
admet-553	7	30	hazards	hazard	NOUN
admet-553	7	31	including	include	VERB
admet-553	7	32	the	the	DET
admet-553	7	33	bioconcentration	bioconcentration	NOUN
admet-553	7	34	factor	factor	NOUN
admet-553	7	35	and	and	CCONJ
admet-553	7	36	aquatic	aquatic	ADJ
admet-553	7	37	organisms	organism	NOUN
admet-553	7	38	’	'	PUNCT
admet-553	7	39	toxicity	toxicity	NOUN
admet-553	7	40	.	.	PUNCT
admet-553	8	1	the	the	DET
admet-553	8	2	promising	promising	ADJ
admet-553	8	3	results	result	NOUN
admet-553	8	4	in	in	ADP
admet-553	8	5	both	both	CCONJ
admet-553	8	6	medicinal	medicinal	ADJ
admet-553	8	7	chemistry	chemistry	NOUN
admet-553	8	8	and	and	CCONJ
admet-553	8	9	in	in	ADP
admet-553	8	10	environmental	environmental	ADJ
admet-553	8	11	science	science	NOUN
admet-553	8	12	in	in	ADP
admet-553	8	13	combination	combination	NOUN
admet-553	8	14	with	with	ADP
admet-553	8	15	the	the	DET
admet-553	8	16	speed	speed	NOUN
admet-553	8	17	,	,	PUNCT
admet-553	8	18	reproducibility	reproducibility	NOUN
admet-553	8	19	and	and	CCONJ
admet-553	8	20	low	low	ADJ
admet-553	8	21	analyte	analyte	NOUN
admet-553	8	22	consumption	consumption	NOUN
admet-553	8	23	suggest	suggest	VERB
admet-553	8	24	that	that	SCONJ
admet-553	8	25	a	a	DET
admet-553	8	26	broader	broad	ADJ
admet-553	8	27	application	application	NOUN
admet-553	8	28	of	of	ADP
admet-553	8	29	iam	iam	PROPN
admet-553	8	30	chromatography	chromatography	NOUN
admet-553	8	31	in	in	ADP
admet-553	8	32	the	the	DET
admet-553	8	33	early	early	ADJ
admet-553	8	34	drug	drug	NOUN
admet-553	8	35	discovery	discovery	NOUN
admet-553	8	36	process	process	NOUN
admet-553	8	37	and	and	CCONJ
admet-553	8	38	in	in	ADP
admet-553	8	39	ecotoxicity	ecotoxicity	NOUN
admet-553	8	40	may	may	AUX
admet-553	8	41	save	save	VERB
admet-553	8	42	time	time	NOUN
admet-553	8	43	and	and	CCONJ
admet-553	8	44	money	money	NOUN
admet-553	8	45	in	in	ADP
admet-553	8	46	initial	initial	ADJ
admet-553	8	47	drug	drug	NOUN
admet-553	8	48	candidate	candidate	NOUN
admet-553	8	49	selection	selection	NOUN
admet-553	8	50	and	and	CCONJ
admet-553	8	51	will	will	AUX
admet-553	8	52	contribute	contribute	VERB
admet-553	8	53	to	to	ADP
admet-553	8	54	a	a	DET
admet-553	8	55	reduced	reduce	VERB
admet-553	8	56	risk	risk	NOUN
admet-553	8	57	hazard	hazard	NOUN
admet-553	8	58	of	of	ADP
admet-553	8	59	chemicals	chemical	NOUN
admet-553	8	60	.	.	PUNCT
admet-553	9	1	keywords	keyword	VERB
admet-553	9	2	iam	iam	PROPN
admet-553	9	3	chromatography	chromatography	NOUN
admet-553	9	4	;	;	PUNCT
admet-553	9	5	lipophilicity	lipophilicity	NOUN
admet-553	9	6	;	;	PUNCT
admet-553	9	7	phospholipophilicity	phospholipophilicity	NOUN
admet-553	9	8	;	;	PUNCT
admet-553	9	9	membrane	membrane	NOUN
admet-553	9	10	permeability	permeability	NOUN
admet-553	9	11	;	;	PUNCT
admet-553	9	12	human	human	ADJ
admet-553	9	13	oral	oral	ADJ
admet-553	9	14	absorption	absorption	NOUN
admet-553	9	15	;	;	PUNCT
admet-553	9	16	ecotoxicity	ecotoxicity	NOUN
admet-553	9	17	;	;	PUNCT
admet-553	9	18	aquatic	aquatic	ADJ
admet-553	9	19	toxicity	toxicity	NOUN
admet-553	9	20	;	;	PUNCT
admet-553	9	21	bioconcentration	bioconcentration	NOUN
admet-553	9	22	factor	factor	NOUN
admet-553	9	23	(	(	PUNCT
admet-553	9	24	bcf	bcf	NOUN
admet-553	9	25	)	)	PUNCT
admet-553	9	26	introduction	introduction	NOUN
admet-553	9	27	to	to	ADP
admet-553	9	28	iam	iam	VERB
admet-553	9	29	chromatography	chromatography	NOUN
admet-553	9	30	high	high	ADJ
admet-553	9	31	-	-	PUNCT
admet-553	9	32	performance	performance	NOUN
admet-553	9	33	liquid	liquid	ADJ
admet-553	9	34	chromatography	chromatography	NOUN
admet-553	9	35	(	(	PUNCT
admet-553	9	36	hplc	hplc	PROPN
admet-553	9	37	)	)	PUNCT
admet-553	9	38	is	be	AUX
admet-553	9	39	a	a	DET
admet-553	9	40	powerful	powerful	ADJ
admet-553	9	41	analytical	analytical	ADJ
admet-553	9	42	technique	technique	NOUN
admet-553	9	43	based	base	VERB
admet-553	9	44	on	on	ADP
admet-553	9	45	the	the	DET
admet-553	9	46	differentiation	differentiation	NOUN
admet-553	9	47	in	in	ADP
admet-553	9	48	the	the	DET
admet-553	9	49	elution	elution	NOUN
admet-553	9	50	of	of	ADP
admet-553	9	51	different	different	ADJ
admet-553	9	52	compounds	compound	NOUN
admet-553	9	53	in	in	ADP
admet-553	9	54	a	a	DET
admet-553	9	55	given	give	VERB
admet-553	9	56	sample	sample	NOUN
admet-553	9	57	when	when	SCONJ
admet-553	9	58	passed	pass	VERB
admet-553	9	59	through	through	ADP
admet-553	9	60	a	a	DET
admet-553	9	61	chromatographic	chromatographic	ADJ
admet-553	9	62	column	column	NOUN
admet-553	9	63	(	(	PUNCT
admet-553	9	64	stationary	stationary	ADJ
admet-553	9	65	phase	phase	NOUN
admet-553	9	66	)	)	PUNCT
admet-553	9	67	by	by	ADP
admet-553	9	68	the	the	DET
admet-553	9	69	flow	flow	NOUN
admet-553	9	70	of	of	ADP
admet-553	9	71	a	a	DET
admet-553	9	72	mobile	mobile	ADJ
admet-553	9	73	phase	phase	NOUN
admet-553	9	74	.	.	PUNCT
admet-553	10	1	thus	thus	ADV
admet-553	10	2	,	,	PUNCT
admet-553	10	3	dissolved	dissolve	VERB
admet-553	10	4	in	in	ADP
admet-553	10	5	the	the	DET
admet-553	10	6	mobile	mobile	ADJ
admet-553	10	7	phase	phase	NOUN
admet-553	10	8	chemicals	chemical	NOUN
admet-553	10	9	participate	participate	VERB
admet-553	10	10	in	in	ADP
admet-553	10	11	a	a	DET
admet-553	10	12	dynamic	dynamic	ADJ
admet-553	10	13	equilibrium	equilibrium	NOUN
admet-553	10	14	between	between	ADP
admet-553	10	15	the	the	DET
admet-553	10	16	mobile	mobile	ADJ
admet-553	10	17	and	and	CCONJ
admet-553	10	18	stationary	stationary	ADJ
admet-553	10	19	phase	phase	NOUN
admet-553	10	20	and	and	CCONJ
admet-553	10	21	their	their	PRON
admet-553	10	22	elution	elution	NOUN
admet-553	10	23	expresses	express	VERB
admet-553	10	24	their	their	PRON
admet-553	10	25	distribution	distribution	NOUN
admet-553	10	26	coefficients	coefficient	NOUN
admet-553	10	27	between	between	ADP
admet-553	10	28	the	the	DET
admet-553	10	29	two	two	NUM
admet-553	10	30	phases	phase	NOUN
admet-553	10	31	,	,	PUNCT
admet-553	10	32	depending	depend	VERB
admet-553	10	33	on	on	ADP
admet-553	10	34	various	various	ADJ
admet-553	10	35	primary	primary	ADJ
admet-553	10	36	and	and	CCONJ
admet-553	10	37	secondary	secondary	ADJ
admet-553	10	38	interactions	interaction	NOUN
admet-553	10	39	.	.	PUNCT
admet-553	11	1	as	as	SCONJ
admet-553	11	2	several	several	ADJ
admet-553	11	3	pharmacokinetic	pharmacokinetic	ADJ
admet-553	11	4	and	and	CCONJ
admet-553	11	5	ecotoxicological	ecotoxicological	ADJ
admet-553	11	6	properties	property	NOUN
admet-553	11	7	involve	involve	VERB
admet-553	11	8	a	a	DET
admet-553	11	9	dynamic	dynamic	ADJ
admet-553	11	10	distribution	distribution	NOUN
admet-553	11	11	of	of	ADP
admet-553	11	12	xenobiotics	xenobiotic	NOUN
admet-553	11	13	between	between	ADP
admet-553	11	14	general	general	ADJ
admet-553	11	15	circulation	circulation	NOUN
admet-553	11	16	and	and	CCONJ
admet-553	11	17	tissues	tissue	NOUN
admet-553	11	18	,	,	PUNCT
admet-553	11	19	or	or	CCONJ
admet-553	11	20	aqueous	aqueous	ADJ
admet-553	11	21	environment	environment	NOUN
admet-553	11	22	and	and	CCONJ
admet-553	11	23	tissues	tissue	NOUN
admet-553	11	24	of	of	ADP
admet-553	11	25	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-553	11	26	mailto:ftsop@central.ntua.gr	mailto:ftsop@central.ntua.gr	PROPN
admet-553	11	27	f.	f.	PROPN
admet-553	11	28	tsopelas	tsopelas	PROPN
admet-553	11	29	,	,	PUNCT
admet-553	11	30	c.	c.	PROPN
admet-553	11	31	stergiopoulos	stergiopoulos	PROPN
admet-553	11	32	,	,	PUNCT
admet-553	11	33	a.	a.	NOUN
admet-553	11	34	tsantili	tsantili	NOUN
admet-553	11	35	-	-	PUNCT
admet-553	11	36	kakoulidou	kakoulidou	NOUN
admet-553	11	37	admet	admet	PROPN
admet-553	11	38	&	&	CCONJ
admet-553	11	39	dmpk	dmpk	PROPN
admet-553	11	40	6(3	6(3	PROPN
admet-553	11	41	)	)	PUNCT
admet-553	11	42	(	(	PUNCT
admet-553	11	43	2018	2018	NUM
admet-553	11	44	)	)	PUNCT
admet-553	11	45	225	225	NUM
admet-553	11	46	-	-	SYM
admet-553	11	47	241	241	NUM
admet-553	11	48	226	226	NUM
admet-553	11	49	aquatic	aquatic	ADJ
admet-553	11	50	organisms	organism	NOUN
admet-553	11	51	,	,	PUNCT
admet-553	11	52	hplc	hplc	NOUN
admet-553	11	53	can	can	AUX
admet-553	11	54	be	be	AUX
admet-553	11	55	used	use	VERB
admet-553	11	56	in	in	ADP
admet-553	11	57	order	order	NOUN
admet-553	11	58	to	to	PART
admet-553	11	59	predict	predict	VERB
admet-553	11	60	pharmacokinetic	pharmacokinetic	ADJ
admet-553	11	61	properties	property	NOUN
admet-553	11	62	and	and	CCONJ
admet-553	11	63	environmental	environmental	ADJ
admet-553	11	64	risk	risk	NOUN
admet-553	11	65	indices	index	NOUN
admet-553	11	66	.	.	PUNCT
admet-553	12	1	the	the	DET
admet-553	12	2	strategy	strategy	NOUN
admet-553	12	3	and	and	CCONJ
admet-553	12	4	the	the	DET
admet-553	12	5	key	key	ADJ
admet-553	12	6	advantages	advantage	NOUN
admet-553	12	7	of	of	ADP
admet-553	12	8	using	use	VERB
admet-553	12	9	hplc	hplc	NOUN
admet-553	12	10	as	as	ADP
admet-553	12	11	a	a	DET
admet-553	12	12	tool	tool	NOUN
admet-553	12	13	to	to	PART
admet-553	12	14	achieve	achieve	VERB
admet-553	12	15	biomimetic	biomimetic	ADJ
admet-553	12	16	conditions	condition	NOUN
admet-553	12	17	have	have	AUX
admet-553	12	18	been	be	AUX
admet-553	12	19	addressed	address	VERB
admet-553	12	20	by	by	ADP
admet-553	12	21	valko	valko	NOUN
admet-553	12	22	[	[	X
admet-553	12	23	1,2	1,2	NUM
admet-553	12	24	]	]	PUNCT
admet-553	12	25	.	.	PUNCT
admet-553	13	1	the	the	DET
admet-553	13	2	use	use	NOUN
admet-553	13	3	of	of	ADP
admet-553	13	4	a	a	DET
admet-553	13	5	chromatographic	chromatographic	ADJ
admet-553	13	6	index	index	NOUN
admet-553	13	7	(	(	PUNCT
admet-553	13	8	e.g.	e.g.	ADV
admet-553	13	9	retention	retention	NOUN
admet-553	13	10	factor	factor	NOUN
admet-553	13	11	)	)	PUNCT
admet-553	13	12	as	as	ADP
admet-553	13	13	a	a	DET
admet-553	13	14	measure	measure	NOUN
admet-553	13	15	of	of	ADP
admet-553	13	16	a	a	DET
admet-553	13	17	biological	biological	ADJ
admet-553	13	18	endpoint	endpoint	NOUN
admet-553	13	19	(	(	PUNCT
admet-553	13	20	e.g.	e.g.	ADV
admet-553	13	21	pharmacokinetic	pharmacokinetic	ADJ
admet-553	13	22	properties	property	NOUN
admet-553	13	23	,	,	PUNCT
admet-553	13	24	toxicity	toxicity	NOUN
admet-553	13	25	and	and	CCONJ
admet-553	13	26	ecotoxicological	ecotoxicological	ADJ
admet-553	13	27	profile	profile	NOUN
admet-553	13	28	)	)	PUNCT
admet-553	13	29	has	have	AUX
admet-553	13	30	generated	generate	VERB
admet-553	13	31	quantitative	quantitative	ADJ
admet-553	13	32	retention	retention	NOUN
admet-553	13	33	activity	activity	NOUN
admet-553	13	34	relationships	relationship	NOUN
admet-553	13	35	(	(	PUNCT
admet-553	13	36	qrar	qrar	NOUN
admet-553	13	37	)	)	PUNCT
admet-553	14	1	[	[	X
admet-553	14	2	3	3	NUM
admet-553	14	3	]	]	PUNCT
admet-553	14	4	.	.	PUNCT
admet-553	15	1	the	the	DET
admet-553	15	2	main	main	ADJ
admet-553	15	3	advantage	advantage	NOUN
admet-553	15	4	of	of	ADP
admet-553	15	5	qrar	qrar	NOUN
admet-553	15	6	is	be	AUX
admet-553	15	7	that	that	SCONJ
admet-553	15	8	it	it	PRON
admet-553	15	9	is	be	AUX
admet-553	15	10	not	not	PART
admet-553	15	11	necessary	necessary	ADJ
admet-553	15	12	to	to	PART
admet-553	15	13	know	know	VERB
admet-553	15	14	the	the	DET
admet-553	15	15	values	value	NOUN
admet-553	15	16	of	of	ADP
admet-553	15	17	the	the	DET
admet-553	15	18	molecular	molecular	ADJ
admet-553	15	19	descriptors	descriptor	NOUN
admet-553	15	20	of	of	ADP
admet-553	15	21	the	the	DET
admet-553	15	22	compound	compound	NOUN
admet-553	15	23	under	under	ADP
admet-553	15	24	investigation	investigation	NOUN
admet-553	15	25	in	in	ADP
admet-553	15	26	order	order	NOUN
admet-553	15	27	to	to	PART
admet-553	15	28	estimate	estimate	VERB
admet-553	15	29	its	its	PRON
admet-553	15	30	pharmacokinetic	pharmacokinetic	ADJ
admet-553	15	31	or	or	CCONJ
admet-553	15	32	ecotoxicological	ecotoxicological	ADJ
admet-553	15	33	profile	profile	NOUN
admet-553	15	34	as	as	ADP
admet-553	15	35	in	in	ADP
admet-553	15	36	classic	classic	ADJ
admet-553	15	37	quantitative	quantitative	ADJ
admet-553	15	38	structure	structure	NOUN
admet-553	15	39	-	-	PUNCT
admet-553	15	40	activity	activity	NOUN
admet-553	15	41	relationship	relationship	NOUN
admet-553	15	42	(	(	PUNCT
admet-553	15	43	qsar	qsar	NOUN
admet-553	15	44	)	)	PUNCT
admet-553	15	45	studies	study	NOUN
admet-553	15	46	.	.	PUNCT
admet-553	16	1	this	this	PRON
admet-553	16	2	is	be	AUX
admet-553	16	3	important	important	ADJ
admet-553	16	4	in	in	ADP
admet-553	16	5	the	the	DET
admet-553	16	6	case	case	NOUN
admet-553	16	7	of	of	ADP
admet-553	16	8	new	new	ADJ
admet-553	16	9	compounds	compound	NOUN
admet-553	16	10	.	.	PUNCT
admet-553	17	1	the	the	DET
admet-553	17	2	first	first	ADJ
admet-553	17	3	attempt	attempt	NOUN
admet-553	17	4	of	of	ADP
admet-553	17	5	introducing	introduce	VERB
admet-553	17	6	hplc	hplc	NOUN
admet-553	17	7	to	to	ADP
admet-553	17	8	the	the	DET
admet-553	17	9	modelling	modelling	NOUN
admet-553	17	10	of	of	ADP
admet-553	17	11	biological	biological	ADJ
admet-553	17	12	processes	process	NOUN
admet-553	17	13	with	with	ADP
admet-553	17	14	the	the	DET
admet-553	17	15	employment	employment	NOUN
admet-553	17	16	of	of	ADP
admet-553	17	17	reversed	reverse	VERB
admet-553	17	18	-	-	PUNCT
admet-553	17	19	phase	phase	NOUN
admet-553	17	20	liquid	liquid	ADJ
admet-553	17	21	chromatography	chromatography	NOUN
admet-553	17	22	as	as	ADP
admet-553	17	23	an	an	DET
admet-553	17	24	alternative	alternative	NOUN
admet-553	17	25	for	for	ADP
admet-553	17	26	lipophilicity	lipophilicity	NOUN
admet-553	17	27	assessment	assessment	NOUN
admet-553	17	28	was	be	AUX
admet-553	17	29	made	make	VERB
admet-553	17	30	in	in	ADP
admet-553	17	31	order	order	NOUN
admet-553	17	32	to	to	PART
admet-553	17	33	overcome	overcome	VERB
admet-553	17	34	certain	certain	ADJ
admet-553	17	35	disadvantages	disadvantage	NOUN
admet-553	17	36	of	of	ADP
admet-553	17	37	direct	direct	ADJ
admet-553	17	38	partitioning	partitioning	NOUN
admet-553	17	39	experiments	experiment	NOUN
admet-553	17	40	[	[	X
admet-553	17	41	4	4	NUM
admet-553	17	42	]	]	PUNCT
admet-553	17	43	.	.	PUNCT
admet-553	18	1	lipophilicity	lipophilicity	PROPN
admet-553	18	2	was	be	AUX
admet-553	18	3	known	know	VERB
admet-553	18	4	as	as	ADP
admet-553	18	5	a	a	DET
admet-553	18	6	predominant	predominant	ADJ
admet-553	18	7	determinant	determinant	ADJ
admet-553	18	8	in	in	ADP
admet-553	18	9	drug	drug	NOUN
admet-553	18	10	transport	transport	NOUN
admet-553	18	11	across	across	ADP
admet-553	18	12	membranes	membrane	NOUN
admet-553	18	13	as	as	SCONJ
admet-553	18	14	proved	prove	VERB
admet-553	18	15	by	by	ADP
admet-553	18	16	the	the	DET
admet-553	18	17	traditional	traditional	ADJ
admet-553	18	18	hansch	hansch	NOUN
admet-553	18	19	analysis	analysis	NOUN
admet-553	18	20	[	[	X
admet-553	18	21	5	5	NUM
admet-553	18	22	]	]	PUNCT
admet-553	18	23	.	.	PUNCT
admet-553	19	1	the	the	DET
admet-553	19	2	development	development	NOUN
admet-553	19	3	of	of	ADP
admet-553	19	4	biomimetic	biomimetic	ADJ
admet-553	19	5	chromatographic	chromatographic	ADJ
admet-553	19	6	columns	column	NOUN
admet-553	19	7	provided	provide	VERB
admet-553	19	8	a	a	DET
admet-553	19	9	substantial	substantial	ADJ
admet-553	19	10	advance	advance	NOUN
admet-553	19	11	for	for	ADP
admet-553	19	12	the	the	DET
admet-553	19	13	experimental	experimental	ADJ
admet-553	19	14	evaluation	evaluation	NOUN
admet-553	19	15	of	of	ADP
admet-553	19	16	admet	admet	NOUN
admet-553	19	17	properties	property	NOUN
admet-553	19	18	in	in	ADP
admet-553	19	19	the	the	DET
admet-553	19	20	early	early	ADJ
admet-553	19	21	stages	stage	NOUN
admet-553	19	22	of	of	ADP
admet-553	19	23	drug	drug	NOUN
admet-553	19	24	/	/	SYM
admet-553	19	25	chemical	chemical	NOUN
admet-553	19	26	development	development	NOUN
admet-553	19	27	,	,	PUNCT
admet-553	19	28	combining	combine	VERB
admet-553	19	29	the	the	DET
admet-553	19	30	simulation	simulation	NOUN
admet-553	19	31	of	of	ADP
admet-553	19	32	biological	biological	ADJ
admet-553	19	33	processes	process	NOUN
admet-553	19	34	with	with	ADP
admet-553	19	35	rapid	rapid	ADJ
admet-553	19	36	measurements	measurement	NOUN
admet-553	19	37	[	[	X
admet-553	19	38	6	6	NUM
admet-553	19	39	-	-	SYM
admet-553	19	40	8	8	NUM
admet-553	19	41	]	]	PUNCT
admet-553	19	42	.	.	PUNCT
admet-553	20	1	in	in	ADP
admet-553	20	2	pharmaceutical	pharmaceutical	NOUN
admet-553	20	3	and	and	CCONJ
admet-553	20	4	environmental	environmental	ADJ
admet-553	20	5	sciences	science	NOUN
admet-553	20	6	three	three	NUM
admet-553	20	7	types	type	NOUN
admet-553	20	8	of	of	ADP
admet-553	20	9	biomimetic	biomimetic	ADJ
admet-553	20	10	chromatography	chromatography	NOUN
admet-553	20	11	are	be	AUX
admet-553	20	12	used	use	VERB
admet-553	20	13	;	;	PUNCT
admet-553	20	14	immobilized	immobilize	VERB
admet-553	20	15	artificial	artificial	ADJ
admet-553	20	16	membrane	membrane	NOUN
admet-553	20	17	(	(	PUNCT
admet-553	20	18	iam	iam	PROPN
admet-553	20	19	)	)	PUNCT
admet-553	20	20	,	,	PUNCT
admet-553	20	21	immobilized	immobilize	VERB
admet-553	20	22	plasma	plasma	NOUN
admet-553	20	23	protein	protein	NOUN
admet-553	20	24	chromatography	chromatography	NOUN
admet-553	20	25	as	as	ADV
admet-553	20	26	well	well	ADV
admet-553	20	27	as	as	ADP
admet-553	20	28	biopartitioning	biopartitione	VERB
admet-553	20	29	micellar	micellar	ADJ
admet-553	20	30	chromatography	chromatography	NOUN
admet-553	20	31	(	(	PUNCT
admet-553	20	32	bmc	bmc	PROPN
admet-553	20	33	)	)	PUNCT
admet-553	20	34	.	.	PUNCT
admet-553	21	1	the	the	DET
admet-553	21	2	first	first	ADJ
admet-553	21	3	two	two	NUM
admet-553	21	4	types	type	NOUN
admet-553	21	5	are	be	AUX
admet-553	21	6	based	base	VERB
admet-553	21	7	on	on	ADP
admet-553	21	8	biomimetic	biomimetic	ADJ
admet-553	21	9	stationary	stationary	ADJ
admet-553	21	10	phases	phase	NOUN
admet-553	21	11	,	,	PUNCT
admet-553	21	12	iam	iam	PROPN
admet-553	21	13	and	and	CCONJ
admet-553	21	14	immobilized	immobilized	ADJ
admet-553	21	15	plasma	plasma	NOUN
admet-553	21	16	protein	protein	NOUN
admet-553	21	17	(	(	PUNCT
admet-553	21	18	i.e.	i.e.	X
admet-553	21	19	human	human	ADJ
admet-553	21	20	serum	serum	NOUN
admet-553	21	21	albumin	albumin	NOUN
admet-553	21	22	and	and	CCONJ
admet-553	21	23	alpha-1	alpha-1	NUM
admet-553	21	24	acid	acid	NOUN
admet-553	21	25	glycoprotein	glycoprotein	NOUN
admet-553	21	26	)	)	PUNCT
admet-553	21	27	,	,	PUNCT
admet-553	21	28	respectively	respectively	ADV
admet-553	21	29	.	.	PUNCT
admet-553	22	1	the	the	DET
admet-553	22	2	third	third	ADJ
admet-553	22	3	uses	use	NOUN
admet-553	22	4	reversed	reverse	VERB
admet-553	22	5	phase	phase	NOUN
admet-553	22	6	columns	column	NOUN
admet-553	22	7	and	and	CCONJ
admet-553	22	8	the	the	DET
admet-553	22	9	biological	biological	ADJ
admet-553	22	10	environment	environment	NOUN
admet-553	22	11	is	be	AUX
admet-553	22	12	mimicked	mimic	VERB
admet-553	22	13	by	by	ADP
admet-553	22	14	micellar	micellar	ADJ
admet-553	22	15	mobile	mobile	ADJ
admet-553	22	16	phases	phase	NOUN
admet-553	22	17	obtained	obtain	VERB
admet-553	22	18	upon	upon	SCONJ
admet-553	22	19	addition	addition	NOUN
admet-553	22	20	of	of	ADP
admet-553	22	21	a	a	DET
admet-553	22	22	surfactant	surfactant	NOUN
admet-553	22	23	above	above	ADP
admet-553	22	24	its	its	PRON
admet-553	22	25	critical	critical	ADJ
admet-553	22	26	micellar	micellar	ADJ
admet-553	22	27	concentration	concentration	NOUN
admet-553	22	28	[	[	X
admet-553	22	29	9,10	9,10	X
admet-553	22	30	]	]	X
admet-553	22	31	.	.	PUNCT
admet-553	23	1	the	the	DET
admet-553	23	2	retention	retention	NOUN
admet-553	23	3	under	under	ADP
admet-553	23	4	biomimetic	biomimetic	ADJ
admet-553	23	5	conditions	condition	NOUN
admet-553	23	6	is	be	AUX
admet-553	23	7	referred	refer	VERB
admet-553	23	8	to	to	ADP
admet-553	23	9	as	as	ADP
admet-553	23	10	biomimetic	biomimetic	ADJ
admet-553	23	11	properties	property	NOUN
admet-553	23	12	which	which	PRON
admet-553	23	13	may	may	AUX
admet-553	23	14	play	play	VERB
admet-553	23	15	an	an	DET
admet-553	23	16	essential	essential	ADJ
admet-553	23	17	role	role	NOUN
admet-553	23	18	in	in	ADP
admet-553	23	19	the	the	DET
admet-553	23	20	drug	drug	NOUN
admet-553	23	21	design	design	NOUN
admet-553	23	22	process	process	NOUN
admet-553	23	23	of	of	ADP
admet-553	23	24	selecting	select	VERB
admet-553	23	25	the	the	DET
admet-553	23	26	appropriate	appropriate	ADJ
admet-553	23	27	compound	compound	NOUN
admet-553	23	28	with	with	ADP
admet-553	23	29	the	the	DET
admet-553	23	30	right	right	ADJ
admet-553	23	31	pharmacokinetic/	pharmacokinetic/	NUM
admet-553	23	32	toxicological	toxicological	ADJ
admet-553	23	33	profile	profile	NOUN
admet-553	23	34	to	to	PART
admet-553	23	35	become	become	VERB
admet-553	23	36	an	an	DET
admet-553	23	37	effective	effective	ADJ
admet-553	23	38	drug	drug	NOUN
admet-553	23	39	[	[	X
admet-553	23	40	11	11	NUM
admet-553	23	41	]	]	PUNCT
admet-553	23	42	.	.	PUNCT
admet-553	24	1	biomimetic	biomimetic	ADJ
admet-553	24	2	chromatography	chromatography	NOUN
admet-553	24	3	has	have	VERB
admet-553	24	4	the	the	DET
admet-553	24	5	advantage	advantage	NOUN
admet-553	24	6	of	of	ADP
admet-553	24	7	combining	combine	VERB
admet-553	24	8	simulation	simulation	NOUN
admet-553	24	9	of	of	ADP
admet-553	24	10	the	the	DET
admet-553	24	11	biological	biological	ADJ
admet-553	24	12	environment	environment	NOUN
admet-553	24	13	with	with	ADP
admet-553	24	14	high	high	ADJ
admet-553	24	15	speed	speed	NOUN
admet-553	24	16	,	,	PUNCT
admet-553	24	17	is	be	AUX
admet-553	24	18	economic	economic	ADJ
admet-553	24	19	and	and	CCONJ
admet-553	24	20	user	user	NOUN
admet-553	24	21	friendly	friendly	ADJ
admet-553	24	22	and	and	CCONJ
admet-553	24	23	requires	require	VERB
admet-553	24	24	only	only	ADV
admet-553	24	25	a	a	DET
admet-553	24	26	small	small	ADJ
admet-553	24	27	amount	amount	NOUN
admet-553	24	28	of	of	ADP
admet-553	24	29	the	the	DET
admet-553	24	30	analyte	analyte	NOUN
admet-553	24	31	without	without	ADP
admet-553	24	32	the	the	DET
admet-553	24	33	necessity	necessity	NOUN
admet-553	24	34	to	to	PART
admet-553	24	35	be	be	AUX
admet-553	24	36	pure	pure	ADJ
admet-553	24	37	[	[	X
admet-553	24	38	12,13	12,13	NUM
admet-553	24	39	]	]	PUNCT
admet-553	24	40	.	.	PUNCT
admet-553	25	1	of	of	ADP
admet-553	25	2	particular	particular	ADJ
admet-553	25	3	importance	importance	NOUN
admet-553	25	4	is	be	AUX
admet-553	25	5	the	the	DET
admet-553	25	6	modelling	modelling	NOUN
admet-553	25	7	of	of	ADP
admet-553	25	8	biological	biological	ADJ
admet-553	25	9	membranes	membrane	NOUN
admet-553	25	10	which	which	PRON
admet-553	25	11	constitute	constitute	VERB
admet-553	25	12	barriers	barrier	NOUN
admet-553	25	13	,	,	PUNCT
admet-553	25	14	which	which	PRON
admet-553	25	15	bioactive	bioactive	VERB
admet-553	25	16	compounds	compound	NOUN
admet-553	25	17	have	have	VERB
admet-553	25	18	to	to	PART
admet-553	25	19	cross	cross	VERB
admet-553	25	20	in	in	ADP
admet-553	25	21	order	order	NOUN
admet-553	25	22	to	to	PART
admet-553	25	23	reach	reach	VERB
admet-553	25	24	their	their	PRON
admet-553	25	25	molecular	molecular	ADJ
admet-553	25	26	target	target	NOUN
admet-553	25	27	and	and	CCONJ
admet-553	25	28	exert	exert	VERB
admet-553	25	29	their	their	PRON
admet-553	25	30	pharmacological	pharmacological	ADJ
admet-553	25	31	actions	action	NOUN
admet-553	25	32	or	or	CCONJ
admet-553	25	33	their	their	PRON
admet-553	25	34	potential	potential	ADJ
admet-553	25	35	adverse	adverse	ADJ
admet-553	25	36	effects	effect	NOUN
admet-553	25	37	.	.	PUNCT
admet-553	26	1	membrane	membrane	NOUN
admet-553	26	2	permeability	permeability	NOUN
admet-553	26	3	can	can	AUX
admet-553	26	4	be	be	AUX
admet-553	26	5	modeled	model	VERB
admet-553	26	6	by	by	ADP
admet-553	26	7	a	a	DET
admet-553	26	8	range	range	NOUN
admet-553	26	9	of	of	ADP
admet-553	26	10	approaches	approach	NOUN
admet-553	26	11	,	,	PUNCT
admet-553	26	12	starting	start	VERB
admet-553	26	13	with	with	ADP
admet-553	26	14	the	the	DET
admet-553	26	15	traditional	traditional	ADJ
admet-553	26	16	octanol	octanol	NOUN
admet-553	26	17	-	-	PUNCT
admet-553	26	18	water	water	NOUN
admet-553	26	19	partitioning	partitioning	NOUN
admet-553	26	20	,	,	PUNCT
admet-553	26	21	or	or	CCONJ
admet-553	26	22	liposomes	liposome	VERB
admet-553	26	23	partitioning	partition	VERB
admet-553	26	24	and	and	CCONJ
admet-553	26	25	proceeding	proceed	VERB
admet-553	26	26	to	to	ADP
admet-553	26	27	the	the	DET
admet-553	26	28	development	development	NOUN
admet-553	26	29	of	of	ADP
admet-553	26	30	different	different	ADJ
admet-553	26	31	cell	cell	NOUN
admet-553	26	32	cultures	culture	NOUN
admet-553	26	33	or	or	CCONJ
admet-553	26	34	artificial	artificial	ADJ
admet-553	26	35	membrane	membrane	NOUN
admet-553	26	36	assays	assay	NOUN
admet-553	26	37	,	,	PUNCT
admet-553	26	38	iam	iam	PROPN
admet-553	26	39	chromatography	chromatography	NOUN
admet-553	26	40	however	however	ADV
admet-553	26	41	,	,	PUNCT
admet-553	26	42	constitutes	constitute	VERB
admet-553	26	43	a	a	DET
admet-553	26	44	powerful	powerful	ADJ
admet-553	26	45	alternative	alternative	NOUN
admet-553	26	46	due	due	ADP
admet-553	26	47	to	to	ADP
admet-553	26	48	its	its	PRON
admet-553	26	49	superior	superior	ADJ
admet-553	26	50	performance	performance	NOUN
admet-553	26	51	in	in	ADP
admet-553	26	52	terms	term	NOUN
admet-553	26	53	of	of	ADP
admet-553	26	54	the	the	DET
admet-553	26	55	simplicity	simplicity	NOUN
admet-553	26	56	of	of	ADP
admet-553	26	57	the	the	DET
admet-553	26	58	experiments	experiment	NOUN
admet-553	26	59	,	,	PUNCT
admet-553	26	60	high	high	ADJ
admet-553	26	61	throughput	throughput	NOUN
admet-553	26	62	,	,	PUNCT
admet-553	26	63	reproducibility	reproducibility	NOUN
admet-553	26	64	and	and	CCONJ
admet-553	26	65	the	the	DET
admet-553	26	66	possibility	possibility	NOUN
admet-553	26	67	of	of	ADP
admet-553	26	68	automation	automation	NOUN
admet-553	26	69	.	.	PUNCT
admet-553	27	1	in	in	ADP
admet-553	27	2	this	this	DET
admet-553	27	3	present	present	ADJ
admet-553	27	4	review	review	NOUN
admet-553	27	5	,	,	PUNCT
admet-553	27	6	the	the	DET
admet-553	27	7	latest	late	ADJ
admet-553	27	8	advances	advance	NOUN
admet-553	27	9	in	in	ADP
admet-553	27	10	iam	iam	PROPN
admet-553	27	11	chromatography	chromatography	NOUN
admet-553	27	12	in	in	ADP
admet-553	27	13	both	both	CCONJ
admet-553	27	14	the	the	DET
admet-553	27	15	pharmaceutical	pharmaceutical	NOUN
admet-553	27	16	and	and	CCONJ
admet-553	27	17	the	the	DET
admet-553	27	18	environmental	environmental	ADJ
admet-553	27	19	sciences	science	NOUN
admet-553	27	20	are	be	AUX
admet-553	27	21	presented	present	VERB
admet-553	27	22	and	and	CCONJ
admet-553	27	23	discussed	discuss	VERB
admet-553	27	24	.	.	PUNCT
admet-553	28	1	types	type	NOUN
admet-553	28	2	of	of	ADP
admet-553	28	3	iam	iam	PROPN
admet-553	28	4	stationary	stationary	ADJ
admet-553	28	5	phases	phase	NOUN
admet-553	28	6	and	and	CCONJ
admet-553	28	7	their	their	PRON
admet-553	28	8	interrelation	interrelation	NOUN
admet-553	28	9	iam	iam	PROPN
admet-553	28	10	stationary	stationary	ADJ
admet-553	28	11	phases	phase	NOUN
admet-553	28	12	are	be	AUX
admet-553	28	13	prepared	prepare	VERB
admet-553	28	14	by	by	ADP
admet-553	28	15	immobilization	immobilization	NOUN
admet-553	28	16	of	of	ADP
admet-553	28	17	phospholipids	phospholipid	NOUN
admet-553	28	18	(	(	PUNCT
admet-553	28	19	e.g.	e.g.	ADV
admet-553	28	20	phosphatidylcholine	phosphatidylcholine	NOUN
admet-553	28	21	)	)	PUNCT
admet-553	28	22	on	on	ADP
admet-553	28	23	propylamino	propylamino	NOUN
admet-553	28	24	-	-	PUNCT
admet-553	28	25	silica	silica	NOUN
admet-553	28	26	skeleton	skeleton	NOUN
admet-553	28	27	.	.	PUNCT
admet-553	29	1	at	at	ADP
admet-553	29	2	present	present	ADJ
admet-553	29	3	,	,	PUNCT
admet-553	29	4	three	three	NUM
admet-553	29	5	types	type	NOUN
admet-553	29	6	of	of	ADP
admet-553	29	7	iam	iam	PROPN
admet-553	29	8	columns	column	NOUN
admet-553	29	9	are	be	AUX
admet-553	29	10	commercially	commercially	ADV
admet-553	29	11	available	available	ADJ
admet-553	29	12	;	;	PUNCT
admet-553	29	13	the	the	DET
admet-553	29	14	single	single	ADJ
admet-553	29	15	chain	chain	NOUN
admet-553	29	16	iam.pc	iam.pc	PROPN
admet-553	29	17	(	(	PUNCT
admet-553	29	18	pc	pc	NOUN
admet-553	29	19	stands	stand	VERB
admet-553	29	20	for	for	ADP
admet-553	29	21	“	"	PUNCT
admet-553	29	22	phosphatidylcholine	phosphatidylcholine	NOUN
admet-553	29	23	”	"	PUNCT
admet-553	29	24	)	)	PUNCT
admet-553	29	25	;	;	PUNCT
admet-553	29	26	the	the	DET
admet-553	29	27	double	double	ADJ
admet-553	29	28	-	-	PUNCT
admet-553	29	29	chain	chain	NOUN
admet-553	29	30	iam.pc.mg	iam.pc.mg	NUM
admet-553	29	31	(	(	PUNCT
admet-553	29	32	mg	mg	PROPN
admet-553	29	33	stands	stand	VERB
admet-553	29	34	for	for	ADP
admet-553	29	35	“	"	PUNCT
admet-553	29	36	methylglycolate	methylglycolate	NOUN
admet-553	29	37	”	"	PUNCT
admet-553	29	38	)	)	PUNCT
admet-553	29	39	and	and	CCONJ
admet-553	29	40	the	the	DET
admet-553	29	41	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	29	42	(	(	PUNCT
admet-553	29	43	dd	dd	VERB
admet-553	29	44	stands	stand	VERB
admet-553	29	45	for	for	ADP
admet-553	29	46	“	"	PUNCT
admet-553	29	47	drug	drug	NOUN
admet-553	29	48	discovery	discovery	NOUN
admet-553	29	49	”	"	PUNCT
admet-553	29	50	)	)	PUNCT
admet-553	29	51	.	.	PUNCT
admet-553	30	1	according	accord	VERB
admet-553	30	2	to	to	ADP
admet-553	30	3	its	its	PRON
admet-553	30	4	producer	producer	NOUN
admet-553	30	5	iam.pc	iam.pc	PROPN
admet-553	30	6	and	and	CCONJ
admet-553	30	7	iam.pc.mg	iam.pc.mg	PROPN
admet-553	30	8	are	be	AUX
admet-553	30	9	suggested	suggest	VERB
admet-553	30	10	for	for	ADP
admet-553	30	11	“	"	PUNCT
admet-553	30	12	membrane	membrane	ADJ
admet-553	30	13	protein	protein	NOUN
admet-553	30	14	purification	purification	NOUN
admet-553	30	15	”	"	PUNCT
admet-553	30	16	,	,	PUNCT
admet-553	30	17	while	while	SCONJ
admet-553	30	18	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	30	19	is	be	AUX
admet-553	30	20	recommended	recommend	VERB
admet-553	30	21	admet	admet	PROPN
admet-553	30	22	&	&	CCONJ
admet-553	30	23	dmpk	dmpk	PROPN
admet-553	30	24	6(3	6(3	PROPN
admet-553	30	25	)	)	PUNCT
admet-553	30	26	(	(	PUNCT
admet-553	30	27	2018	2018	NUM
admet-553	30	28	)	)	PUNCT
admet-553	30	29	225	225	NUM
admet-553	30	30	-	-	SYM
admet-553	30	31	241	241	NUM
admet-553	30	32	iam	iam	PROPN
admet-553	30	33	chromatography	chromatography	NOUN
admet-553	30	34	in	in	ADP
admet-553	30	35	medicinal	medicinal	ADJ
admet-553	30	36	chemistry	chemistry	NOUN
admet-553	30	37	and	and	CCONJ
admet-553	30	38	environment	environment	NOUN
admet-553	30	39	doi	doi	PROPN
admet-553	30	40	:	:	PUNCT
admet-553	30	41	10.5599	10.5599	NUM
admet-553	30	42	/	/	SYM
admet-553	30	43	admet.553	admet.553	NOUN
admet-553	30	44	227	227	NUM
admet-553	30	45	for	for	ADP
admet-553	30	46	drug	drug	NOUN
admet-553	30	47	discovery	discovery	NOUN
admet-553	30	48	purposes	purpose	NOUN
admet-553	30	49	.	.	PUNCT
admet-553	31	1	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	31	2	is	be	AUX
admet-553	31	3	available	available	ADJ
admet-553	31	4	in	in	ADP
admet-553	31	5	3	3	NUM
admet-553	31	6	,	,	PUNCT
admet-553	31	7	10	10	NUM
admet-553	31	8	and	and	CCONJ
admet-553	31	9	15	15	NUM
admet-553	31	10	cm	cm	NOUN
admet-553	31	11	long	long	ADJ
admet-553	31	12	columns	column	NOUN
admet-553	31	13	,	,	PUNCT
admet-553	31	14	iam.pc	iam.pc	PROPN
admet-553	31	15	in	in	ADP
admet-553	31	16	15	15	NUM
admet-553	31	17	and	and	CCONJ
admet-553	31	18	30	30	NUM
admet-553	31	19	cm	cm	NOUN
admet-553	31	20	columns	column	NOUN
admet-553	31	21	,	,	PUNCT
admet-553	31	22	while	while	SCONJ
admet-553	31	23	iam.pc.mg	iam.pc.mg	PROPN
admet-553	31	24	is	be	AUX
admet-553	31	25	produced	produce	VERB
admet-553	31	26	in	in	ADP
admet-553	31	27	3	3	NUM
admet-553	31	28	and	and	CCONJ
admet-553	31	29	15	15	NUM
admet-553	31	30	cm	cm	NOUN
admet-553	31	31	length	length	NOUN
admet-553	31	32	columns	column	NOUN
admet-553	31	33	.	.	PUNCT
admet-553	32	1	all	all	DET
admet-553	32	2	types	type	NOUN
admet-553	32	3	of	of	ADP
admet-553	32	4	the	the	DET
admet-553	32	5	columns	column	NOUN
admet-553	32	6	have	have	VERB
admet-553	32	7	an	an	DET
admet-553	32	8	i.d	i.d	PROPN
admet-553	32	9	.	.	PROPN
admet-553	32	10	of	of	ADP
admet-553	32	11	4.6	4.6	NUM
admet-553	32	12	mm	mm	NOUN
admet-553	32	13	and	and	CCONJ
admet-553	32	14	a	a	DET
admet-553	32	15	stationary	stationary	ADJ
admet-553	32	16	phase	phase	NOUN
admet-553	32	17	of	of	ADP
admet-553	32	18	10	10	NUM
admet-553	32	19	μm	μm	NOUN
admet-553	32	20	particle	particle	NOUN
admet-553	32	21	size	size	NOUN
admet-553	32	22	.	.	PUNCT
admet-553	33	1	an	an	DET
admet-553	33	2	iam	iam	PROPN
admet-553	33	3	fastscreen	fastscreen	PROPN
admet-553	33	4	mini	mini	ADJ
admet-553	33	5	column	column	NOUN
admet-553	33	6	(	(	PUNCT
admet-553	33	7	1	1	NUM
admet-553	33	8	cm	cm	NOUN
admet-553	33	9	x	x	SYM
admet-553	33	10	3	3	NUM
admet-553	33	11	mm	mm	NOUN
admet-553	33	12	)	)	PUNCT
admet-553	33	13	is	be	AUX
admet-553	33	14	also	also	ADV
admet-553	33	15	available	available	ADJ
admet-553	33	16	for	for	ADP
admet-553	33	17	rapid	rapid	ADJ
admet-553	33	18	estimations	estimation	NOUN
admet-553	33	19	of	of	ADP
admet-553	33	20	drug	drug	NOUN
admet-553	33	21	permeability	permeability	NOUN
admet-553	33	22	in	in	ADP
admet-553	33	23	highthroughput	highthroughput	ADJ
admet-553	33	24	screening	screen	VERB
admet-553	33	25	programs	program	NOUN
admet-553	33	26	for	for	ADP
admet-553	33	27	the	the	DET
admet-553	33	28	characterization	characterization	NOUN
admet-553	33	29	of	of	ADP
admet-553	33	30	large	large	ADJ
admet-553	33	31	libraries	library	NOUN
admet-553	33	32	of	of	ADP
admet-553	33	33	compounds	compound	NOUN
admet-553	33	34	[	[	X
admet-553	33	35	14	14	NUM
admet-553	33	36	]	]	PUNCT
admet-553	33	37	.	.	PUNCT
admet-553	34	1	according	accord	VERB
admet-553	34	2	to	to	ADP
admet-553	34	3	the	the	DET
admet-553	34	4	literature	literature	NOUN
admet-553	34	5	,	,	PUNCT
admet-553	34	6	not	not	PART
admet-553	34	7	only	only	ADV
admet-553	34	8	the	the	DET
admet-553	34	9	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	34	10	column	column	NOUN
admet-553	34	11	but	but	CCONJ
admet-553	34	12	also	also	ADV
admet-553	34	13	the	the	DET
admet-553	34	14	iam.pc.mg	iam.pc.mg	PROPN
admet-553	34	15	column	column	NOUN
admet-553	34	16	are	be	AUX
admet-553	34	17	widely	widely	ADV
admet-553	34	18	employed	employ	VERB
admet-553	34	19	in	in	ADP
admet-553	34	20	pharmaceutical	pharmaceutical	NOUN
admet-553	34	21	[	[	X
admet-553	34	22	15	15	NUM
admet-553	34	23	-	-	SYM
admet-553	34	24	20	20	NUM
admet-553	34	25	]	]	PUNCT
admet-553	34	26	and	and	CCONJ
admet-553	34	27	environmental	environmental	ADJ
admet-553	34	28	research	research	NOUN
admet-553	34	29	[	[	X
admet-553	34	30	21	21	NUM
admet-553	34	31	]	]	PUNCT
admet-553	34	32	.	.	PUNCT
admet-553	35	1	the	the	DET
admet-553	35	2	difference	difference	NOUN
admet-553	35	3	between	between	ADP
admet-553	35	4	the	the	DET
admet-553	35	5	two	two	NUM
admet-553	35	6	columns	column	NOUN
admet-553	35	7	is	be	AUX
admet-553	35	8	in	in	ADP
admet-553	35	9	the	the	DET
admet-553	35	10	end	end	NOUN
admet-553	35	11	-	-	PUNCT
admet-553	35	12	capping	capping	NOUN
admet-553	35	13	of	of	ADP
admet-553	35	14	the	the	DET
admet-553	35	15	free	free	ADJ
admet-553	35	16	(	(	PUNCT
admet-553	35	17	unreacted	unreacted	ADJ
admet-553	35	18	)	)	PUNCT
admet-553	35	19	propylamino	propylamino	NOUN
admet-553	35	20	residues	residue	NOUN
admet-553	35	21	,	,	PUNCT
admet-553	35	22	performed	perform	VERB
admet-553	35	23	either	either	ADV
admet-553	35	24	by	by	ADP
admet-553	35	25	methylglycolate	methylglycolate	NOUN
admet-553	35	26	or	or	CCONJ
admet-553	35	27	decyl	decyl	NOUN
admet-553	35	28	/	/	SYM
admet-553	35	29	propyl	propyl	NOUN
admet-553	35	30	anhydride	anhydride	NOUN
admet-553	35	31	as	as	SCONJ
admet-553	35	32	described	describe	VERB
admet-553	35	33	in	in	ADP
admet-553	35	34	detail	detail	NOUN
admet-553	35	35	in	in	ADP
admet-553	35	36	the	the	DET
admet-553	35	37	literature	literature	NOUN
admet-553	35	38	[	[	X
admet-553	35	39	6,7,22	6,7,22	NUM
admet-553	35	40	-	-	SYM
admet-553	35	41	24	24	NUM
admet-553	35	42	]	]	PUNCT
admet-553	35	43	.	.	PUNCT
admet-553	36	1	previous	previous	ADJ
admet-553	36	2	comparative	comparative	ADJ
admet-553	36	3	investigations	investigation	NOUN
admet-553	36	4	on	on	ADP
admet-553	36	5	the	the	DET
admet-553	36	6	two	two	NUM
admet-553	36	7	iam	iam	PROPN
admet-553	36	8	stationary	stationary	ADJ
admet-553	36	9	phases	phase	NOUN
admet-553	36	10	using	use	VERB
admet-553	36	11	a	a	DET
admet-553	36	12	structurally	structurally	ADV
admet-553	36	13	diverse	diverse	ADJ
admet-553	36	14	set	set	NOUN
admet-553	36	15	of	of	ADP
admet-553	36	16	compounds	compound	NOUN
admet-553	36	17	[	[	X
admet-553	36	18	16,18,25	16,18,25	NUM
admet-553	36	19	-	-	SYM
admet-553	36	20	27	27	NUM
admet-553	36	21	]	]	PUNCT
admet-553	36	22	showed	show	VERB
admet-553	36	23	a	a	DET
admet-553	36	24	similar	similar	ADJ
admet-553	36	25	underlying	underlying	ADJ
admet-553	36	26	elution	elution	NOUN
admet-553	36	27	mechanism	mechanism	NOUN
admet-553	36	28	with	with	ADP
admet-553	36	29	an	an	DET
admet-553	36	30	almost	almost	ADV
admet-553	36	31	1:1	1:1	NUM
admet-553	36	32	correlation	correlation	NOUN
admet-553	36	33	between	between	ADP
admet-553	36	34	the	the	DET
admet-553	36	35	retention	retention	NOUN
admet-553	36	36	factors	factor	NOUN
admet-553	36	37	measured	measure	VERB
admet-553	36	38	in	in	ADP
admet-553	36	39	a	a	DET
admet-553	36	40	pure	pure	ADJ
admet-553	36	41	aqueous	aqueous	ADJ
admet-553	36	42	phase	phase	NOUN
admet-553	36	43	,	,	PUNCT
admet-553	36	44	log	log	NOUN
admet-553	36	45	kw(iam	kw(iam	NOUN
admet-553	36	46	)	)	PUNCT
admet-553	36	47	.	.	PUNCT
admet-553	37	1	a	a	DET
admet-553	37	2	representative	representative	ADJ
admet-553	37	3	interrelationship	interrelationship	NOUN
admet-553	37	4	based	base	VERB
admet-553	37	5	on	on	ADP
admet-553	37	6	161	161	NUM
admet-553	37	7	structurally	structurally	ADV
admet-553	37	8	diverse	diverse	ADJ
admet-553	37	9	compounds	compound	NOUN
admet-553	37	10	is	be	AUX
admet-553	37	11	expressed	express	VERB
admet-553	37	12	by	by	ADP
admet-553	37	13	eq.(1	eq.(1	ADJ
admet-553	37	14	)	)	PUNCT
admet-553	38	1	[	[	X
admet-553	38	2	27	27	NUM
admet-553	38	3	]	]	PUNCT
admet-553	38	4	:	:	PUNCT
admet-553	38	5	log	log	VERB
admet-553	38	6	kw(iam.dd2	kw(iam.dd2	PROPN
admet-553	38	7	)	)	PUNCT
admet-553	39	1	=	=	PUNCT
admet-553	40	1	0.1437	0.1437	NUM
admet-553	40	2	+	+	CCONJ
admet-553	40	3	1.0757	1.0757	NUM
admet-553	40	4	·	·	PUNCT
admet-553	40	5	log	log	NOUN
admet-553	40	6	kw(iam.pc.mg	kw(iam.pc.mg	PROPN
admet-553	40	7	)	)	PUNCT
admet-553	40	8	(	(	PUNCT
admet-553	40	9	1	1	X
admet-553	40	10	)	)	PUNCT
admet-553	40	11	(	(	PUNCT
admet-553	40	12	n=161	n=161	ADJ
admet-553	40	13	,	,	PUNCT
admet-553	40	14	r2=0.93	r2=0.93	INTJ
admet-553	40	15	,	,	PUNCT
admet-553	40	16	s=0.314	s=0.314	ADJ
admet-553	40	17	)	)	PUNCT
admet-553	40	18	where	where	SCONJ
admet-553	40	19	n	n	PRON
admet-553	40	20	is	be	AUX
admet-553	40	21	the	the	DET
admet-553	40	22	number	number	NOUN
admet-553	40	23	of	of	ADP
admet-553	40	24	compounds	compound	NOUN
admet-553	40	25	,	,	PUNCT
admet-553	40	26	r	r	NOUN
admet-553	40	27	2	2	NUM
admet-553	40	28	is	be	AUX
admet-553	40	29	the	the	DET
admet-553	40	30	correlation	correlation	NOUN
admet-553	40	31	coefficient	coefficient	NOUN
admet-553	40	32	and	and	CCONJ
admet-553	40	33	s	s	NOUN
admet-553	40	34	is	be	AUX
admet-553	40	35	the	the	DET
admet-553	40	36	standard	standard	ADJ
admet-553	40	37	deviation	deviation	NOUN
admet-553	40	38	.	.	PUNCT
admet-553	41	1	the	the	DET
admet-553	41	2	similarity	similarity	NOUN
admet-553	41	3	between	between	ADP
admet-553	41	4	the	the	DET
admet-553	41	5	two	two	NUM
admet-553	41	6	columns	column	NOUN
admet-553	41	7	permits	permit	VERB
admet-553	41	8	the	the	DET
admet-553	41	9	combination	combination	NOUN
admet-553	41	10	of	of	ADP
admet-553	41	11	retention	retention	NOUN
admet-553	41	12	factors	factor	NOUN
admet-553	41	13	measured	measure	VERB
admet-553	41	14	on	on	ADP
admet-553	41	15	both	both	DET
admet-553	41	16	iam	iam	PROPN
admet-553	41	17	stationary	stationary	ADJ
admet-553	41	18	phases	phase	NOUN
admet-553	41	19	in	in	ADP
admet-553	41	20	order	order	NOUN
admet-553	41	21	to	to	PART
admet-553	41	22	model	model	VERB
admet-553	41	23	biological	biological	ADJ
admet-553	41	24	processes	process	NOUN
admet-553	41	25	.	.	PUNCT
admet-553	42	1	iam	iam	PROPN
admet-553	42	2	indices	index	NOUN
admet-553	42	3	and	and	CCONJ
admet-553	42	4	conditions	condition	NOUN
admet-553	42	5	used	use	VERB
admet-553	42	6	the	the	DET
admet-553	42	7	most	most	ADV
admet-553	42	8	common	common	ADJ
admet-553	42	9	approach	approach	NOUN
admet-553	42	10	for	for	ADP
admet-553	42	11	the	the	DET
admet-553	42	12	employment	employment	NOUN
admet-553	42	13	of	of	ADP
admet-553	42	14	iam	iam	PROPN
admet-553	42	15	chromatography	chromatography	NOUN
admet-553	42	16	is	be	AUX
admet-553	42	17	the	the	DET
admet-553	42	18	simple	simple	ADJ
admet-553	42	19	determination	determination	NOUN
admet-553	42	20	of	of	ADP
admet-553	42	21	the	the	DET
admet-553	42	22	retention	retention	NOUN
admet-553	42	23	factor	factor	NOUN
admet-553	42	24	of	of	ADP
admet-553	42	25	the	the	DET
admet-553	42	26	solute	solute	NOUN
admet-553	42	27	,	,	PUNCT
admet-553	42	28	according	accord	VERB
admet-553	42	29	to	to	ADP
admet-553	42	30	eq	eq	PROPN
admet-553	42	31	.	.	PUNCT
admet-553	43	1	(	(	PUNCT
admet-553	43	2	2	2	NUM
admet-553	43	3	):	):	PUNCT
admet-553	43	4	0	0	NUM
admet-553	43	5	0	0	NUM
admet-553	43	6	r	r	NOUN
admet-553	43	7	(	(	PUNCT
admet-553	43	8	)	)	PUNCT
admet-553	43	9	t	t	PROPN
admet-553	43	10	t	t	PROPN
admet-553	43	11	k	k	PROPN
admet-553	43	12	iam	iam	PROPN
admet-553	44	1	t	t	PROPN
admet-553	44	2			PROPN
admet-553	44	3	(	(	PUNCT
admet-553	44	4	2	2	NUM
admet-553	44	5	)	)	PUNCT
admet-553	44	6	where	where	SCONJ
admet-553	44	7	tr	tr	PRON
admet-553	44	8	is	be	AUX
admet-553	44	9	the	the	DET
admet-553	44	10	retention	retention	NOUN
admet-553	44	11	of	of	ADP
admet-553	44	12	the	the	DET
admet-553	44	13	test	test	NOUN
admet-553	44	14	compound	compound	NOUN
admet-553	44	15	and	and	CCONJ
admet-553	44	16	t0	t0	PROPN
admet-553	44	17	is	be	AUX
admet-553	44	18	the	the	DET
admet-553	44	19	elution	elution	NOUN
admet-553	44	20	time	time	NOUN
admet-553	44	21	of	of	ADP
admet-553	44	22	an	an	DET
admet-553	44	23	unretained	unretained	ADJ
admet-553	44	24	compound	compound	NOUN
admet-553	44	25	,	,	PUNCT
admet-553	44	26	such	such	ADJ
admet-553	44	27	as	as	ADP
admet-553	44	28	sodium	sodium	NOUN
admet-553	44	29	citrate	citrate	NOUN
admet-553	44	30	,	,	PUNCT
admet-553	44	31	lcysteine	lcysteine	ADJ
admet-553	44	32	or	or	CCONJ
admet-553	44	33	ammonium	ammonium	NOUN
admet-553	44	34	oxalate	oxalate	NOUN
admet-553	44	35	[	[	X
admet-553	44	36	28	28	NUM
admet-553	44	37	]	]	PUNCT
admet-553	44	38	.	.	PUNCT
admet-553	45	1	the	the	DET
admet-553	45	2	iam	iam	PROPN
admet-553	45	3	retention	retention	NOUN
admet-553	45	4	factor	factor	NOUN
admet-553	45	5	,	,	PUNCT
admet-553	45	6	k(iam	k(iam	PROPN
admet-553	45	7	)	)	PUNCT
admet-553	45	8	,	,	PUNCT
admet-553	45	9	is	be	AUX
admet-553	45	10	proportional	proportional	ADJ
admet-553	45	11	to	to	ADP
admet-553	45	12	the	the	DET
admet-553	45	13	partition	partition	NOUN
admet-553	45	14	coefficient	coefficient	NOUN
admet-553	45	15	,	,	PUNCT
admet-553	45	16	k(iam	k(iam	PROPN
admet-553	45	17	)	)	PUNCT
admet-553	45	18	,	,	PUNCT
admet-553	45	19	between	between	ADP
admet-553	45	20	the	the	DET
admet-553	45	21	iam	iam	PROPN
admet-553	45	22	stationary	stationary	ADJ
admet-553	45	23	phase	phase	NOUN
admet-553	45	24	and	and	CCONJ
admet-553	45	25	the	the	DET
admet-553	45	26	mobile	mobile	ADJ
admet-553	45	27	phase	phase	NOUN
admet-553	45	28	according	accord	VERB
admet-553	45	29	to	to	ADP
admet-553	45	30	equation	equation	NOUN
admet-553	45	31	(	(	PUNCT
admet-553	45	32	3	3	NUM
admet-553	45	33	):	):	PUNCT
admet-553	45	34	s=	s=	NOUN
admet-553	45	35	×	×	PROPN
admet-553	45	36	(	(	PUNCT
admet-553	45	37	iam	iam	PROPN
admet-553	45	38	)	)	PUNCT
admet-553	45	39	(	(	PUNCT
admet-553	45	40	iam	iam	PROPN
admet-553	45	41	)	)	PUNCT
admet-553	45	42	m	m	PROPN
admet-553	45	43	v	v	ADP
admet-553	45	44	k	k	PROPN
admet-553	45	45	k	k	X
admet-553	45	46	v	v	PROPN
admet-553	45	47	(	(	PUNCT
admet-553	45	48	3	3	NUM
admet-553	45	49	)	)	PUNCT
admet-553	45	50	where	where	SCONJ
admet-553	45	51	vs	vs	ADP
admet-553	45	52	and	and	CCONJ
admet-553	45	53	vm	vm	PROPN
admet-553	45	54	are	be	AUX
admet-553	45	55	the	the	DET
admet-553	45	56	volumes	volume	NOUN
admet-553	45	57	of	of	ADP
admet-553	45	58	stationary	stationary	ADJ
admet-553	45	59	and	and	CCONJ
admet-553	45	60	mobile	mobile	ADJ
admet-553	45	61	phase	phase	NOUN
admet-553	45	62	,	,	PUNCT
admet-553	45	63	respectively	respectively	ADV
admet-553	45	64	,	,	PUNCT
admet-553	45	65	whose	whose	DET
admet-553	45	66	ratio	ratio	NOUN
admet-553	45	67	for	for	ADP
admet-553	45	68	a	a	DET
admet-553	45	69	given	give	VERB
admet-553	45	70	column	column	NOUN
admet-553	45	71	is	be	AUX
admet-553	45	72	constant	constant	ADJ
admet-553	45	73	.	.	PUNCT
admet-553	46	1	for	for	ADP
admet-553	46	2	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	46	3	,	,	PUNCT
admet-553	46	4	vs	vs	PROPN
admet-553	46	5	/	/	SYM
admet-553	46	6	vm	vm	NOUN
admet-553	46	7	is	be	AUX
admet-553	46	8	equal	equal	ADJ
admet-553	46	9	to	to	ADP
admet-553	46	10	0.053	0.053	NUM
admet-553	46	11	[	[	X
admet-553	46	12	29	29	NUM
admet-553	46	13	]	]	PUNCT
admet-553	46	14	and	and	CCONJ
admet-553	46	15	,	,	PUNCT
admet-553	46	16	therefore	therefore	ADV
admet-553	46	17	,	,	PUNCT
admet-553	46	18	the	the	DET
admet-553	46	19	k(iam)/k(iam	k(iam)/k(iam	PROPN
admet-553	46	20	)	)	PUNCT
admet-553	46	21	relation	relation	NOUN
admet-553	46	22	is	be	AUX
admet-553	46	23	given	give	VERB
admet-553	46	24	according	accord	VERB
admet-553	46	25	to	to	ADP
admet-553	46	26	eq	eq	PROPN
admet-553	46	27	.	.	PUNCT
admet-553	47	1	(	(	PUNCT
admet-553	47	2	4	4	NUM
admet-553	47	3	):	):	SYM
admet-553	47	4	1	1	NUM
admet-553	47	5	r	r	NOUN
admet-553	47	6	0	0	NUM
admet-553	47	7	=	=	SYM
admet-553	47	8	×	×	NOUN
admet-553	47	9	=	=	SYM
admet-553	47	10	18.9	18.9	NUM
admet-553	47	11	×	×	NOUN
admet-553	47	12	(	(	PUNCT
admet-553	47	13	iam	iam	PROPN
admet-553	47	14	)	)	PUNCT
admet-553	47	15	(	(	PUNCT
admet-553	48	1	iam)0.053	iam)0.053	PROPN
admet-553	48	2	0	0	PUNCT
admet-553	49	1	t	t	PROPN
admet-553	49	2	t	t	PROPN
admet-553	49	3	k	k	PROPN
admet-553	49	4	k	k	PROPN
admet-553	49	5	t	t	PROPN
admet-553	49	6	(	(	PUNCT
admet-553	49	7	4	4	NUM
admet-553	49	8	)	)	PUNCT
admet-553	49	9	in	in	ADP
admet-553	49	10	modelling	model	VERB
admet-553	49	11	biological	biological	ADJ
admet-553	49	12	processes	process	NOUN
admet-553	49	13	or	or	CCONJ
admet-553	49	14	ecotoxicity	ecotoxicity	NOUN
admet-553	49	15	,	,	PUNCT
admet-553	49	16	retention	retention	NOUN
admet-553	49	17	factors	factor	NOUN
admet-553	49	18	are	be	AUX
admet-553	49	19	usually	usually	ADV
admet-553	49	20	used	use	VERB
admet-553	49	21	in	in	ADP
admet-553	49	22	their	their	PRON
admet-553	49	23	logarithmic	logarithmic	ADJ
admet-553	49	24	form	form	NOUN
admet-553	49	25	in	in	ADP
admet-553	49	26	order	order	NOUN
admet-553	49	27	to	to	PART
admet-553	49	28	achieve	achieve	VERB
admet-553	49	29	linear	linear	ADJ
admet-553	49	30	relationships	relationship	NOUN
admet-553	49	31	with	with	ADP
admet-553	49	32	free	free	ADJ
admet-553	49	33	energy	energy	NOUN
admet-553	49	34	.	.	PUNCT
admet-553	50	1	iam	iam	PROPN
admet-553	50	2	measurements	measurement	NOUN
admet-553	50	3	are	be	AUX
admet-553	50	4	performed	perform	VERB
admet-553	50	5	at	at	ADP
admet-553	50	6	ambient	ambient	ADJ
admet-553	50	7	temperature	temperature	NOUN
admet-553	50	8	[	[	X
admet-553	50	9	17,20,26,30	17,20,26,30	NUM
admet-553	50	10	-	-	SYM
admet-553	50	11	34	34	NUM
admet-553	50	12	]	]	PUNCT
admet-553	50	13	contrary	contrary	ADV
admet-553	50	14	to	to	ADP
admet-553	50	15	biopartitioning	biopartitione	VERB
admet-553	50	16	micellar	micellar	ADJ
admet-553	50	17	chromatography	chromatography	NOUN
admet-553	50	18	which	which	PRON
admet-553	50	19	is	be	AUX
admet-553	50	20	usually	usually	ADV
admet-553	50	21	employed	employ	VERB
admet-553	50	22	at	at	ADP
admet-553	50	23	36.5	36.5	NUM
admet-553	50	24	-	-	SYM
admet-553	50	25	37.0	37.0	NUM
admet-553	50	26	°	°	NUM
admet-553	50	27	c	c	NOUN
admet-553	50	28	[	[	X
admet-553	50	29	9	9	NUM
admet-553	50	30	,	,	PUNCT
admet-553	50	31	10	10	NUM
admet-553	50	32	]	]	PUNCT
admet-553	50	33	.	.	PUNCT
admet-553	51	1	mobile	mobile	ADJ
admet-553	51	2	phases	phase	NOUN
admet-553	51	3	consist	consist	VERB
admet-553	51	4	of	of	ADP
admet-553	51	5	a	a	DET
admet-553	51	6	buffer	buffer	NOUN
admet-553	51	7	,	,	PUNCT
admet-553	51	8	typically	typically	ADV
admet-553	51	9	phosphate	phosphate	ADJ
admet-553	51	10	-	-	PUNCT
admet-553	51	11	buffered	buffer	VERB
admet-553	51	12	saline	saline	NOUN
admet-553	51	13	(	(	PUNCT
admet-553	51	14	pbs	pbs	PROPN
admet-553	51	15	)	)	PUNCT
admet-553	51	16	in	in	ADP
admet-553	51	17	order	order	NOUN
admet-553	51	18	to	to	PART
admet-553	51	19	mimic	mimic	VERB
admet-553	51	20	physiological	physiological	ADJ
admet-553	51	21	conditions	condition	NOUN
admet-553	51	22	.	.	PUNCT
admet-553	52	1	a	a	DET
admet-553	52	2	limitation	limitation	NOUN
admet-553	52	3	in	in	ADP
admet-553	52	4	the	the	DET
admet-553	52	5	preparation	preparation	NOUN
admet-553	52	6	of	of	ADP
admet-553	52	7	mobile	mobile	ADJ
admet-553	52	8	phases	phase	NOUN
admet-553	52	9	is	be	AUX
admet-553	52	10	f.	f.	PROPN
admet-553	52	11	tsopelas	tsopelas	PROPN
admet-553	52	12	,	,	PUNCT
admet-553	52	13	c.	c.	PROPN
admet-553	52	14	stergiopoulos	stergiopoulos	PROPN
admet-553	52	15	,	,	PUNCT
admet-553	52	16	a.	a.	NOUN
admet-553	52	17	tsantili	tsantili	NOUN
admet-553	52	18	-	-	PUNCT
admet-553	52	19	kakoulidou	kakoulidou	NOUN
admet-553	52	20	admet	admet	PROPN
admet-553	52	21	&	&	CCONJ
admet-553	52	22	dmpk	dmpk	PROPN
admet-553	52	23	6(3	6(3	PROPN
admet-553	52	24	)	)	PUNCT
admet-553	52	25	(	(	PUNCT
admet-553	52	26	2018	2018	NUM
admet-553	52	27	)	)	PUNCT
admet-553	52	28	225	225	NUM
admet-553	52	29	-	-	SYM
admet-553	52	30	241	241	NUM
admet-553	52	31	228	228	NUM
admet-553	52	32	their	their	PRON
admet-553	52	33	ph	ph	ADJ
admet-553	52	34	value	value	NOUN
admet-553	52	35	,	,	PUNCT
admet-553	52	36	which	which	PRON
admet-553	52	37	should	should	AUX
admet-553	52	38	be	be	AUX
admet-553	52	39	adjusted	adjust	VERB
admet-553	52	40	to	to	ADP
admet-553	52	41	between	between	ADP
admet-553	52	42	2.5	2.5	NUM
admet-553	52	43	and	and	CCONJ
admet-553	52	44	7.4	7.4	NUM
admet-553	52	45	.	.	PUNCT
admet-553	53	1	although	although	SCONJ
admet-553	53	2	it	it	PRON
admet-553	53	3	is	be	AUX
admet-553	53	4	common	common	ADJ
admet-553	53	5	to	to	PART
admet-553	53	6	add	add	VERB
admet-553	53	7	an	an	DET
admet-553	53	8	organic	organic	ADJ
admet-553	53	9	modifier	modifier	NOUN
admet-553	53	10	to	to	ADP
admet-553	53	11	the	the	DET
admet-553	53	12	mobile	mobile	ADJ
admet-553	53	13	phases	phase	NOUN
admet-553	53	14	,	,	PUNCT
admet-553	53	15	iam	iam	PROPN
admet-553	53	16	stationary	stationary	ADJ
admet-553	53	17	phases	phase	NOUN
admet-553	53	18	can	can	AUX
admet-553	53	19	also	also	ADV
admet-553	53	20	be	be	AUX
admet-553	53	21	used	use	VERB
admet-553	53	22	with	with	ADP
admet-553	53	23	a	a	DET
admet-553	53	24	pure	pure	ADJ
admet-553	53	25	aqueous	aqueous	ADJ
admet-553	53	26	phase	phase	NOUN
admet-553	53	27	[	[	X
admet-553	53	28	26,28,31,34,35	26,28,31,34,35	NOUN
admet-553	53	29	]	]	X
admet-553	53	30	.	.	PUNCT
admet-553	54	1	in	in	ADP
admet-553	54	2	such	such	ADJ
admet-553	54	3	cases	case	NOUN
admet-553	54	4	,	,	PUNCT
admet-553	54	5	the	the	DET
admet-553	54	6	measured	measure	VERB
admet-553	54	7	log	log	NOUN
admet-553	54	8	k(iam	k(iam	PROPN
admet-553	54	9	)	)	PUNCT
admet-553	54	10	values	value	NOUN
admet-553	54	11	correspond	correspond	VERB
admet-553	54	12	to	to	ADP
admet-553	54	13	the	the	DET
admet-553	54	14	actual	actual	ADJ
admet-553	54	15	log	log	NOUN
admet-553	54	16	kw(iam	kw(iam	NOUN
admet-553	54	17	)	)	PUNCT
admet-553	54	18	values	value	NOUN
admet-553	54	19	,	,	PUNCT
admet-553	54	20	where	where	SCONJ
admet-553	54	21	the	the	DET
admet-553	54	22	symbol	symbol	NOUN
admet-553	54	23	“	"	PUNCT
admet-553	54	24	w	w	PROPN
admet-553	54	25	”	"	PUNCT
admet-553	54	26	denotes	denote	VERB
admet-553	54	27	the	the	DET
admet-553	54	28	pure	pure	ADJ
admet-553	54	29	aqueous	aqueous	ADJ
admet-553	54	30	phase	phase	NOUN
admet-553	54	31	.	.	PUNCT
admet-553	55	1	in	in	ADP
admet-553	55	2	the	the	DET
admet-553	55	3	case	case	NOUN
admet-553	55	4	of	of	ADP
admet-553	55	5	compounds	compound	NOUN
admet-553	55	6	exhibiting	exhibit	VERB
admet-553	55	7	strong	strong	ADJ
admet-553	55	8	affinity	affinity	NOUN
admet-553	55	9	with	with	ADP
admet-553	55	10	the	the	DET
admet-553	55	11	iam	iam	PROPN
admet-553	55	12	stationary	stationary	ADJ
admet-553	55	13	phase	phase	NOUN
admet-553	55	14	,	,	PUNCT
admet-553	55	15	acetonitrile	acetonitrile	NOUN
admet-553	55	16	can	can	AUX
admet-553	55	17	be	be	AUX
admet-553	55	18	added	add	VERB
admet-553	55	19	up	up	ADP
admet-553	55	20	to	to	ADP
admet-553	55	21	concentrations	concentration	NOUN
admet-553	55	22	of	of	ADP
admet-553	55	23	30	30	NUM
admet-553	55	24	%	%	NOUN
admet-553	55	25	and	and	CCONJ
admet-553	55	26	log	log	PROPN
admet-553	55	27	kw(iam	kw(iam	NOUN
admet-553	55	28	)	)	PUNCT
admet-553	55	29	values	value	NOUN
admet-553	55	30	can	can	AUX
admet-553	55	31	be	be	AUX
admet-553	55	32	obtained	obtain	VERB
admet-553	55	33	by	by	ADP
admet-553	55	34	linear	linear	ADJ
admet-553	55	35	extrapolation	extrapolation	NOUN
admet-553	55	36	of	of	ADP
admet-553	55	37	isocratic	isocratic	ADJ
admet-553	55	38	log	log	NOUN
admet-553	55	39	k(iam	k(iam	PROPN
admet-553	55	40	)	)	PUNCT
admet-553	55	41	values	value	NOUN
admet-553	55	42	,	,	PUNCT
admet-553	55	43	measured	measure	VERB
admet-553	55	44	in	in	ADP
admet-553	55	45	the	the	DET
admet-553	55	46	presence	presence	NOUN
admet-553	55	47	of	of	ADP
admet-553	55	48	at	at	ADV
admet-553	55	49	least	least	ADV
admet-553	55	50	four	four	NUM
admet-553	55	51	different	different	ADJ
admet-553	55	52	acetonitrile	acetonitrile	ADJ
admet-553	55	53	fractions	fraction	NOUN
admet-553	55	54	(	(	PUNCT
admet-553	55	55	φ	φ	NOUN
admet-553	55	56	)	)	PUNCT
admet-553	55	57	in	in	ADP
admet-553	55	58	the	the	DET
admet-553	55	59	mobile	mobile	ADJ
admet-553	55	60	phase	phase	NOUN
admet-553	55	61	,	,	PUNCT
admet-553	55	62	according	accord	VERB
admet-553	55	63	to	to	ADP
admet-553	55	64	eq.(5	eq.(5	NOUN
admet-553	55	65	):	):	PUNCT
admet-553	55	66	log	log	NOUN
admet-553	55	67	=	=	SYM
admet-553	55	68	log	log	PROPN
admet-553	55	69	×	×	NOUN
admet-553	55	70	(	(	PUNCT
admet-553	55	71	iam	iam	PROPN
admet-553	55	72	)	)	PUNCT
admet-553	55	73	w(iam)k	w(iam)k	NOUN
admet-553	56	1	k	k	PROPN
admet-553	56	2	s	s	PROPN
admet-553	56	3	φ	φ	X
admet-553	56	4	(	(	PUNCT
admet-553	56	5	5	5	NUM
admet-553	56	6	)	)	PUNCT
admet-553	56	7	where	where	SCONJ
admet-553	56	8	s	s	NOUN
admet-553	56	9	is	be	AUX
admet-553	56	10	the	the	DET
admet-553	56	11	slope	slope	NOUN
admet-553	56	12	of	of	ADP
admet-553	56	13	the	the	DET
admet-553	56	14	log	log	NOUN
admet-553	56	15	k	k	PROPN
admet-553	56	16	vs	vs	ADP
admet-553	56	17	φ	φ	PROPN
admet-553	56	18	relationship	relationship	NOUN
admet-553	56	19	,	,	PUNCT
admet-553	56	20	calculated	calculate	VERB
admet-553	56	21	by	by	ADP
admet-553	56	22	linear	linear	PROPN
admet-553	56	23	regression	regression	NOUN
admet-553	56	24	.	.	PUNCT
admet-553	57	1	comparative	comparative	ADJ
admet-553	57	2	studies	study	NOUN
admet-553	57	3	between	between	ADP
admet-553	57	4	actual	actual	ADJ
admet-553	57	5	and	and	CCONJ
admet-553	57	6	extrapolated	extrapolate	VERB
admet-553	57	7	log	log	NOUN
admet-553	57	8	kw(iam	kw(iam	NOUN
admet-553	57	9	)	)	PUNCT
admet-553	57	10	values	value	NOUN
admet-553	57	11	showed	show	VERB
admet-553	57	12	only	only	ADV
admet-553	57	13	small	small	ADJ
admet-553	57	14	differences	difference	NOUN
admet-553	58	1	[	[	X
admet-553	58	2	17,26	17,26	NOUN
admet-553	58	3	]	]	X
admet-553	58	4	.	.	PUNCT
admet-553	59	1	such	such	ADJ
admet-553	59	2	findings	finding	NOUN
admet-553	59	3	permit	permit	VERB
admet-553	59	4	the	the	DET
admet-553	59	5	combined	combine	VERB
admet-553	59	6	use	use	NOUN
admet-553	59	7	of	of	ADP
admet-553	59	8	actual	actual	ADJ
admet-553	59	9	log	log	NOUN
admet-553	59	10	kw(iam	kw(iam	NOUN
admet-553	59	11	)	)	PUNCT
admet-553	59	12	values	value	NOUN
admet-553	59	13	with	with	ADP
admet-553	59	14	extrapolated	extrapolated	ADJ
admet-553	59	15	values	value	NOUN
admet-553	59	16	in	in	ADP
admet-553	59	17	the	the	DET
admet-553	59	18	case	case	NOUN
admet-553	59	19	of	of	ADP
admet-553	59	20	lipophilic	lipophilic	ADJ
admet-553	59	21	compounds	compound	NOUN
admet-553	59	22	.	.	PUNCT
admet-553	60	1	however	however	ADV
admet-553	60	2	,	,	PUNCT
admet-553	60	3	the	the	DET
admet-553	60	4	use	use	NOUN
admet-553	60	5	of	of	ADP
admet-553	60	6	mobile	mobile	ADJ
admet-553	60	7	phases	phase	NOUN
admet-553	60	8	with	with	ADP
admet-553	60	9	high	high	ADJ
admet-553	60	10	concentration	concentration	NOUN
admet-553	60	11	of	of	ADP
admet-553	60	12	acetonitrile	acetonitrile	NOUN
admet-553	60	13	should	should	AUX
admet-553	60	14	be	be	AUX
admet-553	60	15	avoided	avoid	VERB
admet-553	60	16	as	as	SCONJ
admet-553	60	17	the	the	DET
admet-553	60	18	structure	structure	NOUN
admet-553	60	19	of	of	ADP
admet-553	60	20	water	water	NOUN
admet-553	60	21	layer	layer	NOUN
admet-553	60	22	on	on	ADP
admet-553	60	23	the	the	DET
admet-553	60	24	stationary	stationary	ADJ
admet-553	60	25	phase	phase	NOUN
admet-553	60	26	surface	surface	NOUN
admet-553	60	27	can	can	AUX
admet-553	60	28	be	be	AUX
admet-553	60	29	disrupted	disrupt	VERB
admet-553	60	30	[	[	X
admet-553	60	31	36	36	NUM
admet-553	60	32	]	]	PUNCT
admet-553	60	33	.	.	PUNCT
admet-553	61	1	the	the	DET
admet-553	61	2	use	use	NOUN
admet-553	61	3	of	of	ADP
admet-553	61	4	methanol	methanol	NOUN
admet-553	61	5	as	as	ADP
admet-553	61	6	an	an	DET
admet-553	61	7	organic	organic	ADJ
admet-553	61	8	modifier	modifier	NOUN
admet-553	61	9	should	should	AUX
admet-553	61	10	also	also	ADV
admet-553	61	11	be	be	AUX
admet-553	61	12	avoided	avoid	VERB
admet-553	61	13	as	as	SCONJ
admet-553	61	14	it	it	PRON
admet-553	61	15	can	can	AUX
admet-553	61	16	cause	cause	VERB
admet-553	61	17	instability	instability	NOUN
admet-553	61	18	of	of	ADP
admet-553	61	19	the	the	DET
admet-553	61	20	stationary	stationary	ADJ
admet-553	61	21	phase	phase	NOUN
admet-553	61	22	due	due	ADP
admet-553	61	23	to	to	ADP
admet-553	61	24	methanolysis	methanolysis	NOUN
admet-553	61	25	of	of	ADP
admet-553	61	26	the	the	DET
admet-553	61	27	phospholipids	phospholipid	NOUN
admet-553	62	1	[	[	X
admet-553	62	2	37,38	37,38	NOUN
admet-553	62	3	]	]	PUNCT
admet-553	62	4	.	.	PUNCT
admet-553	63	1	to	to	ADP
admet-553	63	2	this	this	DET
admet-553	63	3	point	point	NOUN
admet-553	63	4	,	,	PUNCT
admet-553	63	5	the	the	DET
admet-553	63	6	high	high	ADJ
admet-553	63	7	interand	interand	VERB
admet-553	63	8	intra	intra	ADJ
admet-553	63	9	-	-	ADJ
admet-553	63	10	laboratory	laboratory	ADJ
admet-553	63	11	reproducibility	reproducibility	NOUN
admet-553	63	12	of	of	ADP
admet-553	63	13	actual	actual	ADJ
admet-553	63	14	or	or	CCONJ
admet-553	63	15	extrapolated	extrapolate	VERB
admet-553	63	16	log	log	NOUN
admet-553	63	17	kw(iam	kw(iam	NOUN
admet-553	63	18	)	)	PUNCT
admet-553	63	19	values	value	NOUN
admet-553	63	20	under	under	ADP
admet-553	63	21	standard	standard	ADJ
admet-553	63	22	conditions	condition	NOUN
admet-553	63	23	(	(	PUNCT
admet-553	63	24	buffer	buffer	VERB
admet-553	63	25	pbs	pb	NOUN
admet-553	63	26	and	and	CCONJ
admet-553	63	27	acetonitrile	acetonitrile	NOUN
admet-553	63	28	as	as	ADP
admet-553	63	29	organic	organic	ADJ
admet-553	63	30	modifier	modifier	NOUN
admet-553	63	31	)	)	PUNCT
admet-553	63	32	should	should	AUX
admet-553	63	33	be	be	AUX
admet-553	63	34	highlighted	highlight	VERB
admet-553	63	35	[	[	X
admet-553	63	36	7	7	NUM
admet-553	63	37	]	]	PUNCT
admet-553	63	38	.	.	PUNCT
admet-553	64	1	as	as	ADP
admet-553	64	2	an	an	DET
admet-553	64	3	alternative	alternative	NOUN
admet-553	64	4	to	to	ADP
admet-553	64	5	using	use	VERB
admet-553	64	6	iam	iam	PROPN
admet-553	64	7	retention	retention	NOUN
admet-553	64	8	factors	factor	NOUN
admet-553	64	9	,	,	PUNCT
admet-553	64	10	valko	valko	PROPN
admet-553	64	11	has	have	AUX
admet-553	64	12	proposed	propose	VERB
admet-553	64	13	the	the	DET
admet-553	64	14	chromatographic	chromatographic	ADJ
admet-553	64	15	hydrophobicity	hydrophobicity	NOUN
admet-553	64	16	index	index	NOUN
admet-553	64	17	for	for	ADP
admet-553	64	18	iam	iam	PROPN
admet-553	64	19	chromatography	chromatography	NOUN
admet-553	64	20	,	,	PUNCT
admet-553	64	21	chi(iam	chi(iam	PROPN
admet-553	64	22	)	)	PUNCT
admet-553	65	1	[	[	X
admet-553	65	2	1,39,40	1,39,40	NUM
admet-553	65	3	]	]	X
admet-553	65	4	,	,	PUNCT
admet-553	65	5	which	which	PRON
admet-553	65	6	,	,	PUNCT
admet-553	65	7	in	in	ADP
admet-553	65	8	recent	recent	ADJ
admet-553	65	9	literature	literature	NOUN
admet-553	65	10	,	,	PUNCT
admet-553	65	11	has	have	AUX
admet-553	65	12	been	be	AUX
admet-553	65	13	also	also	ADV
admet-553	65	14	termed	term	VERB
admet-553	65	15	as	as	ADP
admet-553	65	16	“	"	PUNCT
admet-553	65	17	membrane	membrane	ADJ
admet-553	65	18	binding	bind	VERB
admet-553	65	19	index	index	NOUN
admet-553	65	20	”	"	PUNCT
admet-553	65	21	(	(	PUNCT
admet-553	65	22	iam	iam	PROPN
admet-553	65	23	mb	mb	PROPN
admet-553	65	24	)	)	PUNCT
admet-553	66	1	[	[	X
admet-553	66	2	41	41	NUM
admet-553	66	3	]	]	PUNCT
admet-553	66	4	.	.	PUNCT
admet-553	67	1	chi(iam	chi(iam	X
admet-553	67	2	)	)	PUNCT
admet-553	67	3	corresponds	correspond	VERB
admet-553	67	4	to	to	ADP
admet-553	67	5	the	the	DET
admet-553	67	6	percentage	percentage	NOUN
admet-553	67	7	of	of	ADP
admet-553	67	8	acetonitrile	acetonitrile	NOUN
admet-553	67	9	required	require	VERB
admet-553	67	10	for	for	ADP
admet-553	67	11	the	the	DET
admet-553	67	12	equal	equal	ADJ
admet-553	67	13	partitioning	partitioning	NOUN
admet-553	67	14	of	of	ADP
admet-553	67	15	the	the	DET
admet-553	67	16	solute	solute	NOUN
admet-553	67	17	between	between	ADP
admet-553	67	18	the	the	DET
admet-553	67	19	mobile	mobile	NOUN
admet-553	67	20	and	and	CCONJ
admet-553	67	21	the	the	DET
admet-553	67	22	stationary	stationary	ADJ
admet-553	67	23	phase	phase	NOUN
admet-553	67	24	(	(	PUNCT
admet-553	67	25	e.i	e.i	PROPN
admet-553	67	26	.	.	PROPN
admet-553	67	27	log	log	PROPN
admet-553	67	28	k=0	k=0	PROPN
admet-553	67	29	)	)	PUNCT
admet-553	67	30	,	,	PUNCT
admet-553	67	31	which	which	PRON
admet-553	67	32	according	accord	VERB
admet-553	67	33	to	to	ADP
admet-553	67	34	eq.(5	eq.(5	NOUN
admet-553	67	35	)	)	PUNCT
admet-553	67	36	is	be	AUX
admet-553	67	37	equal	equal	ADJ
admet-553	67	38	to	to	ADP
admet-553	67	39	φ0	φ0	PROPN
admet-553	67	40	=	=	NOUN
admet-553	67	41	log	log	NOUN
admet-553	67	42	kw(iam)/	kw(iam)/	ADV
admet-553	67	43	s.	s.	PROPN
admet-553	67	44	the	the	DET
admet-553	67	45	rapid	rapid	ADJ
admet-553	67	46	determination	determination	NOUN
admet-553	67	47	of	of	ADP
admet-553	67	48	chi(iam	chi(iam	NOUN
admet-553	67	49	)	)	PUNCT
admet-553	68	1	[	[	X
admet-553	68	2	1,39	1,39	X
admet-553	68	3	]	]	X
admet-553	68	4	can	can	AUX
admet-553	68	5	be	be	AUX
admet-553	68	6	easily	easily	ADV
admet-553	68	7	performed	perform	VERB
admet-553	68	8	by	by	ADP
admet-553	68	9	the	the	DET
admet-553	68	10	measurement	measurement	NOUN
admet-553	68	11	of	of	ADP
admet-553	68	12	the	the	DET
admet-553	68	13	gradient	gradient	PROPN
admet-553	68	14	elution	elution	NOUN
admet-553	68	15	times	time	NOUN
admet-553	68	16	(	(	PUNCT
admet-553	68	17	tg	tg	X
admet-553	68	18	)	)	PUNCT
admet-553	68	19	measured	measure	VERB
admet-553	68	20	under	under	ADP
admet-553	68	21	the	the	DET
admet-553	68	22	appropriate	appropriate	ADJ
admet-553	68	23	gradient	gradient	ADJ
admet-553	68	24	conditions	condition	NOUN
admet-553	68	25	.	.	PUNCT
admet-553	69	1	the	the	PRON
admet-553	69	2	obtained	obtain	VERB
admet-553	69	3	tg	tg	PROPN
admet-553	69	4	for	for	ADP
admet-553	69	5	each	each	DET
admet-553	69	6	analyte	analyte	NOUN
admet-553	69	7	is	be	AUX
admet-553	69	8	converted	convert	VERB
admet-553	69	9	to	to	ADP
admet-553	69	10	its	its	PRON
admet-553	69	11	chi(iam	chi(iam	NOUN
admet-553	69	12	)	)	PUNCT
admet-553	69	13	value	value	NOUN
admet-553	69	14	by	by	ADP
admet-553	69	15	using	use	VERB
admet-553	69	16	a	a	DET
admet-553	69	17	linear	linear	ADJ
admet-553	69	18	calibration	calibration	NOUN
admet-553	69	19	equation	equation	NOUN
admet-553	69	20	regression	regression	NOUN
admet-553	69	21	line	line	NOUN
admet-553	69	22	chi(iam)=	chi(iam)=	PROPN
admet-553	69	23	f(tg	f(tg	PROPN
admet-553	69	24	)	)	PUNCT
admet-553	69	25	obtained	obtain	VERB
admet-553	69	26	by	by	ADP
admet-553	69	27	using	use	VERB
admet-553	69	28	9	9	NUM
admet-553	69	29	standard	standard	ADJ
admet-553	69	30	compounds	compound	NOUN
admet-553	69	31	,	,	PUNCT
admet-553	69	32	namely	namely	ADV
admet-553	69	33	octanophenone	octanophenone	ADJ
admet-553	69	34	,	,	PUNCT
admet-553	69	35	heptanophenone	heptanophenone	NOUN
admet-553	69	36	,	,	PUNCT
admet-553	69	37	hexanophenone	hexanophenone	NOUN
admet-553	69	38	,	,	PUNCT
admet-553	69	39	valerophenone	valerophenone	NOUN
admet-553	69	40	,	,	PUNCT
admet-553	69	41	butyrophenone	butyrophenone	NOUN
admet-553	69	42	,	,	PUNCT
admet-553	69	43	propiophenone	propiophenone	NOUN
admet-553	69	44	,	,	PUNCT
admet-553	69	45	acetophenone	acetophenone	PROPN
admet-553	69	46	,	,	PUNCT
admet-553	69	47	acetanilide	acetanilide	ADJ
admet-553	69	48	and	and	CCONJ
admet-553	69	49	paracetamol	paracetamol	VERB
admet-553	69	50	[	[	X
admet-553	69	51	39	39	NUM
admet-553	69	52	]	]	PUNCT
admet-553	69	53	.	.	PUNCT
admet-553	70	1	in	in	ADP
admet-553	70	2	such	such	ADJ
admet-553	70	3	experiments	experiment	NOUN
admet-553	70	4	usually	usually	ADV
admet-553	70	5	,	,	PUNCT
admet-553	70	6	ammonium	ammonium	NOUN
admet-553	70	7	acetate	acetate	NOUN
admet-553	70	8	is	be	AUX
admet-553	70	9	the	the	DET
admet-553	70	10	buffer	buffer	NOUN
admet-553	70	11	,	,	PUNCT
admet-553	70	12	which	which	PRON
admet-553	70	13	is	be	AUX
admet-553	70	14	compatible	compatible	ADJ
admet-553	70	15	with	with	ADP
admet-553	70	16	mass	mass	ADJ
admet-553	70	17	spectrometry	spectrometry	NOUN
admet-553	70	18	,	,	PUNCT
admet-553	70	19	while	while	SCONJ
admet-553	70	20	acetonitrile	acetonitrile	NOUN
admet-553	70	21	is	be	AUX
admet-553	70	22	the	the	DET
admet-553	70	23	organic	organic	ADJ
admet-553	70	24	modifier	modifier	NOUN
admet-553	70	25	[	[	X
admet-553	70	26	39	39	NUM
admet-553	70	27	]	]	PUNCT
admet-553	70	28	.	.	PUNCT
admet-553	71	1	chi(iam	chi(iam	PROPN
admet-553	71	2	)	)	PUNCT
admet-553	71	3	can	can	AUX
admet-553	71	4	be	be	AUX
admet-553	71	5	further	far	ADV
admet-553	71	6	converted	convert	VERB
admet-553	71	7	to	to	PART
admet-553	71	8	log	log	VERB
admet-553	71	9	kw(iam	kw(iam	NOUN
admet-553	71	10	)	)	PUNCT
admet-553	71	11	for	for	ADP
admet-553	71	12	the	the	DET
admet-553	71	13	neutral	neutral	ADJ
admet-553	71	14	form	form	NOUN
admet-553	71	15	of	of	ADP
admet-553	71	16	the	the	DET
admet-553	71	17	molecule	molecule	NOUN
admet-553	71	18	by	by	ADP
admet-553	71	19	means	mean	NOUN
admet-553	71	20	of	of	ADP
admet-553	71	21	eq.(6	eq.(6	NOUN
admet-553	71	22	)	)	PUNCT
admet-553	71	23	which	which	PRON
admet-553	71	24	was	be	AUX
admet-553	71	25	established	establish	VERB
admet-553	71	26	from	from	ADP
admet-553	71	27	86	86	NUM
admet-553	71	28	diverse	diverse	ADJ
admet-553	71	29	drug	drug	NOUN
admet-553	71	30	molecules	molecule	NOUN
admet-553	71	31	[	[	X
admet-553	71	32	11	11	NUM
admet-553	71	33	]	]	PUNCT
admet-553	71	34	.	.	PUNCT
admet-553	72	1	log	log	PROPN
admet-553	72	2	kw(iam)=0.046	kw(iam)=0.046	PROPN
admet-553	72	3	chi(iam	chi(iam	PROPN
admet-553	72	4	)	)	PUNCT
admet-553	73	1	+0.42	+0.42	PRON
admet-553	73	2	(	(	PUNCT
admet-553	73	3	6	6	NUM
admet-553	73	4	)	)	PUNCT
admet-553	73	5	(	(	PUNCT
admet-553	73	6	n=86	n=86	PROPN
admet-553	73	7	,	,	PUNCT
admet-553	73	8	r2=0.94	r2=0.94	NOUN
admet-553	73	9	,	,	PUNCT
admet-553	73	10	s=0.29	s=0.29	NOUN
admet-553	73	11	)	)	PUNCT
admet-553	73	12	relationship	relationship	NOUN
admet-553	73	13	of	of	ADP
admet-553	73	14	iam	iam	PROPN
admet-553	73	15	retention	retention	NOUN
admet-553	73	16	with	with	ADP
admet-553	73	17	lipophilicity	lipophilicity	NOUN
admet-553	73	18	and	and	CCONJ
admet-553	73	19	other	other	ADJ
admet-553	73	20	molecular	molecular	ADJ
admet-553	73	21	factors	factor	NOUN
admet-553	73	22	in	in	ADP
admet-553	73	23	order	order	NOUN
admet-553	73	24	to	to	PART
admet-553	73	25	unravel	unravel	VERB
admet-553	73	26	the	the	DET
admet-553	73	27	potential	potential	ADJ
admet-553	73	28	applications	application	NOUN
admet-553	73	29	of	of	ADP
admet-553	73	30	iam	iam	PROPN
admet-553	73	31	chromatography	chromatography	NOUN
admet-553	73	32	in	in	ADP
admet-553	73	33	pharmaceutical	pharmaceutical	NOUN
admet-553	73	34	and	and	CCONJ
admet-553	73	35	environmental	environmental	ADJ
admet-553	73	36	sciences	science	NOUN
admet-553	73	37	,	,	PUNCT
admet-553	73	38	it	it	PRON
admet-553	73	39	is	be	AUX
admet-553	73	40	crucial	crucial	ADJ
admet-553	73	41	to	to	PART
admet-553	73	42	investigate	investigate	VERB
admet-553	73	43	the	the	DET
admet-553	73	44	elution	elution	NOUN
admet-553	73	45	mechanism	mechanism	NOUN
admet-553	73	46	,	,	PUNCT
admet-553	73	47	governing	govern	VERB
admet-553	73	48	the	the	DET
admet-553	73	49	iam	iam	PROPN
admet-553	73	50	retention	retention	NOUN
admet-553	73	51	mechanism	mechanism	NOUN
admet-553	73	52	.	.	PUNCT
admet-553	74	1	there	there	PRON
admet-553	74	2	is	be	VERB
admet-553	74	3	general	general	ADJ
admet-553	74	4	agreement	agreement	NOUN
admet-553	74	5	that	that	PRON
admet-553	74	6	iam	iam	PROPN
admet-553	74	7	retention	retention	NOUN
admet-553	74	8	is	be	AUX
admet-553	74	9	governed	govern	VERB
admet-553	74	10	by	by	ADP
admet-553	74	11	lipophilicity	lipophilicity	NOUN
admet-553	74	12	,	,	PUNCT
admet-553	74	13	involving	involve	VERB
admet-553	74	14	hydrophobicity	hydrophobicity	NOUN
admet-553	74	15	,	,	PUNCT
admet-553	74	16	polarity	polarity	NOUN
admet-553	74	17	and	and	CCONJ
admet-553	74	18	the	the	DET
admet-553	74	19	additional	additional	ADJ
admet-553	74	20	factors	factor	NOUN
admet-553	74	21	,	,	PUNCT
admet-553	74	22	of	of	ADP
admet-553	74	23	electrostatic	electrostatic	ADJ
admet-553	74	24	interactions	interaction	NOUN
admet-553	74	25	in	in	ADP
admet-553	74	26	the	the	DET
admet-553	74	27	case	case	NOUN
admet-553	74	28	of	of	ADP
admet-553	74	29	ionizable	ionizable	ADJ
admet-553	74	30	compounds	compound	NOUN
admet-553	74	31	(	(	PUNCT
admet-553	74	32	e.g.	e.g.	ADV
admet-553	74	33	deprotonated	deprotonated	ADJ
admet-553	74	34	acids	acid	NOUN
admet-553	74	35	,	,	PUNCT
admet-553	74	36	protonated	protonate	VERB
admet-553	74	37	bases	basis	NOUN
admet-553	74	38	and	and	CCONJ
admet-553	74	39	zwitterions	zwitterion	NOUN
admet-553	74	40	)	)	PUNCT
admet-553	74	41	with	with	ADP
admet-553	74	42	the	the	DET
admet-553	74	43	charged	charge	VERB
admet-553	74	44	centres	centre	NOUN
admet-553	74	45	of	of	ADP
admet-553	74	46	the	the	DET
admet-553	74	47	phospholipids	phospholipid	NOUN
admet-553	74	48	and	and	CCONJ
admet-553	74	49	the	the	DET
admet-553	74	50	consequent	consequent	ADJ
admet-553	74	51	formation	formation	NOUN
admet-553	74	52	of	of	ADP
admet-553	74	53	ionic	ionic	ADJ
admet-553	74	54	bonds	bond	NOUN
admet-553	74	55	[	[	X
admet-553	74	56	17,21,26,31,34,38	17,21,26,31,34,38	NUM
admet-553	74	57	]	]	PUNCT
admet-553	74	58	.	.	PUNCT
admet-553	75	1	in	in	ADP
admet-553	75	2	such	such	ADJ
admet-553	75	3	cases	case	NOUN
admet-553	75	4	,	,	PUNCT
admet-553	75	5	iam	iam	PROPN
admet-553	75	6	retention	retention	NOUN
admet-553	75	7	may	may	AUX
admet-553	75	8	be	be	AUX
admet-553	75	9	considered	consider	VERB
admet-553	75	10	as	as	ADP
admet-553	75	11	a	a	DET
admet-553	75	12	border	border	NOUN
admet-553	75	13	case	case	NOUN
admet-553	75	14	between	between	ADP
admet-553	75	15	passive	passive	ADJ
admet-553	75	16	diffusion	diffusion	NOUN
admet-553	75	17	and	and	CCONJ
admet-553	75	18	binding	binding	NOUN
admet-553	75	19	as	as	SCONJ
admet-553	75	20	was	be	AUX
admet-553	75	21	highlighted	highlight	VERB
admet-553	75	22	by	by	ADP
admet-553	75	23	van	van	PROPN
admet-553	75	24	balen	balen	PROPN
admet-553	75	25	et	et	PROPN
admet-553	75	26	al	al	PROPN
admet-553	75	27	.	.	PUNCT
admet-553	76	1	[	[	X
admet-553	76	2	42	42	NUM
admet-553	76	3	]	]	PUNCT
admet-553	76	4	.	.	PUNCT
admet-553	77	1	the	the	DET
admet-553	77	2	specific	specific	ADJ
admet-553	77	3	contribution	contribution	NOUN
admet-553	77	4	of	of	ADP
admet-553	77	5	each	each	DET
admet-553	77	6	parameter	parameter	NOUN
admet-553	77	7	to	to	ADP
admet-553	77	8	the	the	DET
admet-553	77	9	so	so	ADV
admet-553	77	10	-	-	PUNCT
admet-553	77	11	called	call	VERB
admet-553	77	12	“	"	PUNCT
admet-553	77	13	phospholipophilicity	phospholipophilicity	NOUN
admet-553	77	14	”	"	PUNCT
admet-553	77	15	admet	admet	PROPN
admet-553	77	16	&	&	CCONJ
admet-553	77	17	dmpk	dmpk	PROPN
admet-553	77	18	6(3	6(3	PROPN
admet-553	77	19	)	)	PUNCT
admet-553	77	20	(	(	PUNCT
admet-553	77	21	2018	2018	NUM
admet-553	77	22	)	)	PUNCT
admet-553	77	23	225	225	NUM
admet-553	77	24	-	-	SYM
admet-553	77	25	241	241	NUM
admet-553	77	26	iam	iam	PROPN
admet-553	77	27	chromatography	chromatography	NOUN
admet-553	77	28	in	in	ADP
admet-553	77	29	medicinal	medicinal	ADJ
admet-553	77	30	chemistry	chemistry	NOUN
admet-553	77	31	and	and	CCONJ
admet-553	77	32	environment	environment	NOUN
admet-553	77	33	doi	doi	PROPN
admet-553	77	34	:	:	PUNCT
admet-553	77	35	10.5599	10.5599	NUM
admet-553	77	36	/	/	SYM
admet-553	77	37	admet.553	admet.553	NOUN
admet-553	77	38	229	229	NUM
admet-553	77	39	can	can	AUX
admet-553	77	40	be	be	AUX
admet-553	77	41	expressed	express	VERB
admet-553	77	42	by	by	ADP
admet-553	77	43	eq	eq	PROPN
admet-553	77	44	.	.	PUNCT
admet-553	78	1	(	(	PUNCT
admet-553	78	2	7	7	NUM
admet-553	78	3	)	)	PUNCT
admet-553	78	4	and	and	CCONJ
admet-553	78	5	has	have	AUX
admet-553	78	6	been	be	AUX
admet-553	78	7	discussed	discuss	VERB
admet-553	78	8	in	in	ADP
admet-553	78	9	a	a	DET
admet-553	78	10	previous	previous	ADJ
admet-553	78	11	review	review	NOUN
admet-553	79	1	[	[	X
admet-553	79	2	7,8	7,8	NUM
admet-553	79	3	]	]	PUNCT
admet-553	79	4	:	:	PUNCT
admet-553	79	5	phospholipophilicity	phospholipophilicity	NOUN
admet-553	79	6	=	=	SYM
admet-553	79	7	hydrophobicity	hydrophobicity	NOUN
admet-553	79	8	±	±	NUM
admet-553	79	9	polarity	polarity	NOUN
admet-553	79	10	+	+	CCONJ
admet-553	79	11	electrostatic	electrostatic	ADJ
admet-553	79	12	interactions	interaction	NOUN
admet-553	79	13	(	(	PUNCT
admet-553	79	14	7	7	X
admet-553	79	15	)	)	PUNCT
admet-553	79	16	the	the	DET
admet-553	79	17	sign	sign	NOUN
admet-553	79	18	of	of	ADP
admet-553	79	19	polarity	polarity	NOUN
admet-553	79	20	in	in	ADP
admet-553	79	21	eq	eq	ADP
admet-553	79	22	.	.	PUNCT
admet-553	80	1	(	(	PUNCT
admet-553	80	2	7	7	X
admet-553	80	3	)	)	PUNCT
admet-553	80	4	can	can	AUX
admet-553	80	5	be	be	AUX
admet-553	80	6	negative	negative	ADJ
admet-553	80	7	reducing	reduce	VERB
admet-553	80	8	phospholipophilicity	phospholipophilicity	NOUN
admet-553	80	9	in	in	ADP
admet-553	80	10	an	an	DET
admet-553	80	11	analogous	analogous	ADJ
admet-553	80	12	manner	manner	NOUN
admet-553	80	13	to	to	ADP
admet-553	80	14	its	its	PRON
admet-553	80	15	effect	effect	NOUN
admet-553	80	16	on	on	ADP
admet-553	80	17	lipophilicity	lipophilicity	NOUN
admet-553	80	18	,	,	PUNCT
admet-553	80	19	or	or	CCONJ
admet-553	80	20	positive	positive	ADJ
admet-553	80	21	as	as	ADP
admet-553	80	22	a	a	DET
admet-553	80	23	result	result	NOUN
admet-553	80	24	of	of	ADP
admet-553	80	25	hydrogen	hydrogen	NOUN
admet-553	80	26	bonding	bonding	NOUN
admet-553	80	27	to	to	ADP
admet-553	80	28	the	the	DET
admet-553	80	29	glycerol	glycerol	NOUN
admet-553	80	30	ester	ester	NOUN
admet-553	80	31	group	group	NOUN
admet-553	80	32	of	of	ADP
admet-553	80	33	the	the	DET
admet-553	80	34	phospholipids	phospholipid	NOUN
admet-553	80	35	.	.	PUNCT
admet-553	81	1	electrostatic	electrostatic	ADJ
admet-553	81	2	interactions	interaction	NOUN
admet-553	81	3	lead	lead	VERB
admet-553	81	4	overall	overall	ADV
admet-553	81	5	to	to	ADP
admet-553	81	6	enhanced	enhanced	ADJ
admet-553	81	7	retention	retention	NOUN
admet-553	81	8	,	,	PUNCT
admet-553	81	9	although	although	SCONJ
admet-553	81	10	repulsive	repulsive	ADJ
admet-553	81	11	forces	force	NOUN
admet-553	81	12	between	between	ADP
admet-553	81	13	solute	solute	NOUN
admet-553	81	14	anions	anion	NOUN
admet-553	81	15	and	and	CCONJ
admet-553	81	16	iam	iam	PROPN
admet-553	81	17	phosphate	phosphate	ADJ
admet-553	81	18	groups	group	NOUN
admet-553	81	19	may	may	AUX
admet-553	81	20	also	also	ADV
admet-553	81	21	occur	occur	VERB
admet-553	81	22	.	.	PUNCT
admet-553	82	1	the	the	DET
admet-553	82	2	crucial	crucial	ADJ
admet-553	82	3	role	role	NOUN
admet-553	82	4	of	of	ADP
admet-553	82	5	hydrophobicity	hydrophobicity	NOUN
admet-553	82	6	to	to	ADP
admet-553	82	7	iam	iam	VERB
admet-553	82	8	retention	retention	NOUN
admet-553	82	9	can	can	AUX
admet-553	82	10	be	be	AUX
admet-553	82	11	highlighted	highlight	VERB
admet-553	82	12	by	by	ADP
admet-553	82	13	considering	consider	VERB
admet-553	82	14	log	log	NOUN
admet-553	82	15	kw(iam)/	kw(iam)/	ADV
admet-553	82	16	log	log	VERB
admet-553	82	17	p	p	NOUN
admet-553	82	18	relationships	relationship	NOUN
admet-553	82	19	,	,	PUNCT
admet-553	82	20	which	which	PRON
admet-553	82	21	are	be	AUX
admet-553	82	22	generally	generally	ADV
admet-553	82	23	characterized	characterize	VERB
admet-553	82	24	by	by	ADP
admet-553	82	25	good	good	ADJ
admet-553	82	26	statistics	statistic	NOUN
admet-553	82	27	.	.	PUNCT
admet-553	83	1	in	in	ADP
admet-553	83	2	the	the	DET
admet-553	83	3	case	case	NOUN
admet-553	83	4	of	of	ADP
admet-553	83	5	ionizable	ionizable	ADJ
admet-553	83	6	compounds	compound	NOUN
admet-553	83	7	log	log	NOUN
admet-553	83	8	kw(iam	kw(iam	NOUN
admet-553	83	9	)	)	PUNCT
admet-553	83	10	may	may	AUX
admet-553	83	11	still	still	ADV
admet-553	83	12	correlate	correlate	VERB
admet-553	83	13	better	well	ADV
admet-553	83	14	with	with	ADP
admet-553	83	15	log	log	NOUN
admet-553	83	16	p	p	NOUN
admet-553	83	17	than	than	ADP
admet-553	83	18	log	log	NOUN
admet-553	83	19	d	d	NOUN
admet-553	83	20	as	as	ADP
admet-553	83	21	a	a	DET
admet-553	83	22	result	result	NOUN
admet-553	83	23	of	of	ADP
admet-553	83	24	the	the	DET
admet-553	83	25	partial	partial	ADJ
admet-553	83	26	compensation	compensation	NOUN
admet-553	83	27	of	of	ADP
admet-553	83	28	ionization	ionization	NOUN
admet-553	83	29	via	via	ADP
admet-553	83	30	electrostatic	electrostatic	ADJ
admet-553	83	31	interactions	interaction	NOUN
admet-553	83	32	[	[	X
admet-553	83	33	26	26	NUM
admet-553	83	34	]	]	PUNCT
admet-553	83	35	.	.	PUNCT
admet-553	84	1	however	however	ADV
admet-553	84	2	,	,	PUNCT
admet-553	84	3	the	the	DET
admet-553	84	4	relationship	relationship	NOUN
admet-553	84	5	of	of	ADP
admet-553	84	6	log	log	NOUN
admet-553	84	7	kw(iam	kw(iam	NOUN
admet-553	84	8	)	)	PUNCT
admet-553	84	9	with	with	ADP
admet-553	84	10	log	log	PROPN
admet-553	84	11	d	d	NOUN
admet-553	84	12	can	can	AUX
admet-553	84	13	be	be	AUX
admet-553	84	14	considerably	considerably	ADV
admet-553	84	15	improved	improve	VERB
admet-553	84	16	by	by	ADP
admet-553	84	17	introducing	introduce	VERB
admet-553	84	18	the	the	DET
admet-553	84	19	positively	positively	ADV
admet-553	84	20	(	(	PUNCT
admet-553	84	21	f+	f+	NOUN
admet-553	84	22	)	)	PUNCT
admet-553	84	23	or	or	CCONJ
admet-553	84	24	negatively	negatively	ADV
admet-553	84	25	charged	charge	VERB
admet-553	84	26	(	(	PUNCT
admet-553	84	27	f-	f-	ADJ
admet-553	84	28	)	)	PUNCT
admet-553	84	29	molecular	molecular	ADJ
admet-553	84	30	fraction	fraction	NOUN
admet-553	84	31	of	of	ADP
admet-553	84	32	the	the	DET
admet-553	84	33	analytes	analyte	NOUN
admet-553	84	34	[	[	X
admet-553	84	35	17,21,26,31,34	17,21,26,31,34	X
admet-553	84	36	]	]	X
admet-553	84	37	as	as	ADP
admet-553	84	38	additional	additional	ADJ
admet-553	84	39	parameters	parameter	NOUN
admet-553	84	40	.	.	PUNCT
admet-553	85	1	positive	positive	ADJ
admet-553	85	2	signs	sign	NOUN
admet-553	85	3	(	(	PUNCT
admet-553	85	4	higher	high	ADJ
admet-553	85	5	for	for	ADP
admet-553	85	6	f	f	PROPN
admet-553	85	7	+	+	CCONJ
admet-553	85	8	than	than	ADP
admet-553	85	9	for	for	ADP
admet-553	85	10	f	f	PROPN
admet-553	85	11	)	)	PUNCT
admet-553	85	12	are	be	AUX
admet-553	85	13	generated	generate	VERB
admet-553	85	14	,	,	PUNCT
admet-553	85	15	as	as	SCONJ
admet-553	85	16	shown	show	VERB
admet-553	85	17	in	in	ADP
admet-553	85	18	eq	eq	ADP
admet-553	85	19	.	.	PUNCT
admet-553	86	1	(	(	PUNCT
admet-553	86	2	8)	8)	NUM
admet-553	86	3	at	at	ADP
admet-553	86	4	ph=7.4	ph=7.4	PROPN
admet-553	86	5	,	,	PUNCT
admet-553	86	6	supporting	support	VERB
admet-553	86	7	the	the	DET
admet-553	86	8	overall	overall	ADJ
admet-553	86	9	positive	positive	ADJ
admet-553	86	10	contribution	contribution	NOUN
admet-553	86	11	of	of	ADP
admet-553	86	12	electrostatic	electrostatic	ADJ
admet-553	86	13	interactions	interaction	NOUN
admet-553	86	14	.	.	PUNCT
admet-553	87	1	+	+	CCONJ
admet-553	87	2	-log	-log	X
admet-553	87	3	=	=	SYM
admet-553	87	4	0.62	0.62	NUM
admet-553	87	5	×	×	NOUN
admet-553	87	6	log	log	NOUN
admet-553	87	7	+	+	CCONJ
admet-553	87	8	1.14	1.14	NUM
admet-553	87	9	×	×	NOUN
admet-553	87	10	f	f	PROPN
admet-553	87	11	+	+	CCONJ
admet-553	87	12	0.48	0.48	NUM
admet-553	87	13	×	×	NOUN
admet-553	87	14	f	f	NOUN
admet-553	88	1	+	+	CCONJ
admet-553	88	2	0.327.4w(iam)k	0.327.4w(iam)k	PROPN
admet-553	88	3	d	d	X
admet-553	88	4	(	(	PUNCT
admet-553	88	5	8)	8)	NUM
admet-553	88	6	(	(	PUNCT
admet-553	88	7	n=	n=	ADJ
admet-553	88	8	56	56	NUM
admet-553	88	9	,	,	PUNCT
admet-553	88	10	r2=	r2=	PROPN
admet-553	88	11	0.938	0.938	NUM
admet-553	88	12	,	,	PUNCT
admet-553	88	13	s=	s=	NOUN
admet-553	88	14	0.413	0.413	NUM
admet-553	88	15	)	)	PUNCT
admet-553	88	16	the	the	DET
admet-553	88	17	roustness	roustness	NOUN
admet-553	88	18	of	of	ADP
admet-553	88	19	equation	equation	NOUN
admet-553	88	20	(	(	PUNCT
admet-553	88	21	8)	8)	NUM
admet-553	88	22	has	have	AUX
admet-553	88	23	been	be	AUX
admet-553	88	24	sucessfully	sucessfully	ADV
admet-553	88	25	validated	validate	VERB
admet-553	88	26	by	by	ADP
admet-553	88	27	other	other	ADJ
admet-553	88	28	sets	set	NOUN
admet-553	88	29	of	of	ADP
admet-553	88	30	structurally	structurally	ADV
admet-553	88	31	diverse	diverse	ADJ
admet-553	88	32	drugs	drug	NOUN
admet-553	88	33	[	[	X
admet-553	88	34	17,26	17,26	NOUN
admet-553	88	35	]	]	X
admet-553	88	36	.	.	PUNCT
admet-553	89	1	other	other	ADJ
admet-553	89	2	authors	author	NOUN
admet-553	89	3	have	have	AUX
admet-553	89	4	confirmed	confirm	VERB
admet-553	89	5	the	the	DET
admet-553	89	6	electrostatic	electrostatic	ADJ
admet-553	89	7	interactions	interaction	NOUN
admet-553	89	8	in	in	ADP
admet-553	89	9	iam	iam	PROPN
admet-553	89	10	retention	retention	NOUN
admet-553	89	11	using	use	VERB
admet-553	89	12	linear	linear	PROPN
admet-553	89	13	free	free	ADJ
admet-553	89	14	energy	energy	NOUN
admet-553	89	15	relationships	relationship	NOUN
admet-553	89	16	(	(	PUNCT
admet-553	89	17	lfer	lfer	NOUN
admet-553	89	18	)	)	PUNCT
admet-553	89	19	upon	upon	SCONJ
admet-553	89	20	introduction	introduction	NOUN
admet-553	89	21	of	of	ADP
admet-553	89	22	the	the	DET
admet-553	89	23	ionization	ionization	NOUN
admet-553	89	24	correction	correction	NOUN
admet-553	89	25	factors	factor	NOUN
admet-553	89	26	(	(	PUNCT
admet-553	89	27	δ	δ	NOUN
admet-553	89	28	-	-	PUNCT
admet-553	89	29	correction	correction	NOUN
admet-553	89	30	or	or	CCONJ
admet-553	89	31	j	j	PROPN
admet-553	89	32	+	+	PUNCT
admet-553	89	33	and	and	CCONJ
admet-553	89	34	j	j	PROPN
admet-553	89	35	for	for	ADP
admet-553	89	36	ionic	ionic	ADJ
admet-553	89	37	species	specie	NOUN
admet-553	89	38	)	)	PUNCT
admet-553	89	39	as	as	ADP
admet-553	89	40	additional	additional	ADJ
admet-553	89	41	parameters	parameter	NOUN
admet-553	89	42	[	[	X
admet-553	89	43	43,44	43,44	X
admet-553	89	44	]	]	X
admet-553	89	45	.	.	PUNCT
admet-553	90	1	a	a	DET
admet-553	90	2	representative	representative	ADJ
admet-553	90	3	equation	equation	NOUN
admet-553	90	4	obtained	obtain	VERB
admet-553	90	5	at	at	ADP
admet-553	90	6	ph=7.0	ph=7.0	PROPN
admet-553	90	7	is	be	AUX
admet-553	90	8	shown	show	VERB
admet-553	90	9	in	in	ADP
admet-553	90	10	eq	eq	ADP
admet-553	90	11	.	.	PUNCT
admet-553	91	1	(	(	PUNCT
admet-553	91	2	9	9	NUM
admet-553	91	3	)	)	PUNCT
admet-553	92	1	[	[	X
admet-553	92	2	44	44	NUM
admet-553	92	3	]	]	X
admet-553	92	4	:	:	PUNCT
admet-553	92	5	log	log	VERB
admet-553	92	6	kw(iam)=	kw(iam)=	NOUN
admet-553	92	7	-0.607	-0.607	PUNCT
admet-553	93	1	+	+	CCONJ
admet-553	94	1	0.881	0.881	NUM
admet-553	94	2	·	·	PUNCT
admet-553	94	3	e	e	X
admet-553	94	4	–	–	PUNCT
admet-553	94	5	0.562	0.562	NUM
admet-553	94	6	·	·	PUNCT
admet-553	94	7	s	s	PART
admet-553	94	8	–	–	PUNCT
admet-553	94	9	0.348	0.348	NUM
admet-553	94	10	·	·	PUNCT
admet-553	94	11	a1.794	a1.794	X
admet-553	94	12	·	·	PUNCT
admet-553	95	1	b	b	X
admet-553	95	2	+	+	CCONJ
admet-553	95	3	2.250	2.250	NUM
admet-553	95	4	·	·	SYM
admet-553	95	5	v	v	X
admet-553	95	6	-0.245	-0.245	X
admet-553	95	7	·	·	PUNCT
admet-553	96	1	j+	j+	NUM
admet-553	96	2	+	+	PUNCT
admet-553	96	3	2.010	2.010	NUM
admet-553	96	4	·	·	PUNCT
admet-553	96	5	j	j	NOUN
admet-553	96	6	(	(	PUNCT
admet-553	96	7	9	9	NUM
admet-553	96	8	)	)	PUNCT
admet-553	96	9	(	(	PUNCT
admet-553	96	10	n=68	n=68	ADV
admet-553	96	11	,	,	PUNCT
admet-553	96	12	r2=	r2=	PROPN
admet-553	96	13	0.896	0.896	NUM
admet-553	96	14	,	,	PUNCT
admet-553	96	15	s=0.431	s=0.431	NUM
admet-553	96	16	)	)	PUNCT
admet-553	96	17	in	in	ADP
admet-553	96	18	eq	eq	ADP
admet-553	96	19	.	.	PUNCT
admet-553	96	20	(	(	PUNCT
admet-553	96	21	9	9	NUM
admet-553	96	22	)	)	PUNCT
admet-553	96	23	,	,	PUNCT
admet-553	96	24	the	the	DET
admet-553	96	25	solute	solute	NOUN
admet-553	96	26	descriptors	descriptor	NOUN
admet-553	96	27	are	be	AUX
admet-553	96	28	as	as	SCONJ
admet-553	96	29	follows	follow	VERB
admet-553	96	30	:	:	PUNCT
admet-553	96	31	v	v	NOUN
admet-553	96	32	is	be	AUX
admet-553	96	33	the	the	DET
admet-553	96	34	mcgowan	mcgowan	PROPN
admet-553	96	35	’s	’s	PART
admet-553	96	36	characteristic	characteristic	ADJ
admet-553	96	37	volume	volume	NOUN
admet-553	96	38	,	,	PUNCT
admet-553	96	39	e	e	PROPN
admet-553	96	40	is	be	AUX
admet-553	96	41	the	the	DET
admet-553	96	42	excess	excess	ADJ
admet-553	96	43	molar	molar	ADJ
admet-553	96	44	refraction	refraction	NOUN
admet-553	96	45	,	,	PUNCT
admet-553	96	46	s	s	VERB
admet-553	96	47	is	be	AUX
admet-553	96	48	the	the	DET
admet-553	96	49	dipolarity	dipolarity	NOUN
admet-553	96	50	/	/	SYM
admet-553	96	51	polarizability	polarizability	NOUN
admet-553	96	52	,	,	PUNCT
admet-553	96	53	and	and	CCONJ
admet-553	96	54	a	a	PRON
admet-553	96	55	and	and	CCONJ
admet-553	96	56	b	b	NOUN
admet-553	96	57	are	be	AUX
admet-553	96	58	the	the	DET
admet-553	96	59	hydrogen	hydrogen	NOUN
admet-553	96	60	-	-	PUNCT
admet-553	96	61	bond	bond	NOUN
admet-553	96	62	acidity	acidity	NOUN
admet-553	96	63	and	and	CCONJ
admet-553	96	64	basicity	basicity	NOUN
admet-553	96	65	,	,	PUNCT
admet-553	96	66	respectively	respectively	ADV
admet-553	96	67	.	.	PUNCT
admet-553	97	1	the	the	DET
admet-553	97	2	additional	additional	ADJ
admet-553	97	3	terms	term	NOUN
admet-553	97	4	,	,	PUNCT
admet-553	97	5	δ	δ	NOUN
admet-553	97	6	-	-	NOUN
admet-553	97	7	correction	correction	NOUN
admet-553	97	8	or	or	CCONJ
admet-553	97	9	j+	j+	NUM
admet-553	97	10	and	and	CCONJ
admet-553	97	11	jhave	jhave	VERB
admet-553	97	12	positive	positive	ADJ
admet-553	97	13	signs	sign	NOUN
admet-553	97	14	(	(	PUNCT
admet-553	97	15	higher	high	ADJ
admet-553	97	16	for	for	ADP
admet-553	97	17	cations	cation	NOUN
admet-553	97	18	than	than	ADP
admet-553	97	19	for	for	ADP
admet-553	97	20	anions	anion	NOUN
admet-553	97	21	)	)	PUNCT
admet-553	97	22	.	.	PUNCT
admet-553	98	1	a	a	DET
admet-553	98	2	possible	possible	ADJ
admet-553	98	3	explanation	explanation	NOUN
admet-553	98	4	for	for	ADP
admet-553	98	5	the	the	DET
admet-553	98	6	stronger	strong	ADJ
admet-553	98	7	electrostatic	electrostatic	ADJ
admet-553	98	8	interactions	interaction	NOUN
admet-553	98	9	of	of	ADP
admet-553	98	10	cations	cation	NOUN
admet-553	98	11	is	be	AUX
admet-553	98	12	the	the	DET
admet-553	98	13	location	location	NOUN
admet-553	98	14	of	of	ADP
admet-553	98	15	the	the	DET
admet-553	98	16	iam	iam	PROPN
admet-553	98	17	phosphate	phosphate	ADJ
admet-553	98	18	groups	group	NOUN
admet-553	98	19	close	close	ADJ
admet-553	98	20	to	to	ADP
admet-553	98	21	the	the	DET
admet-553	98	22	hydrophobic	hydrophobic	NOUN
admet-553	98	23	part	part	NOUN
admet-553	98	24	of	of	ADP
admet-553	98	25	phospholipids	phospholipid	NOUN
admet-553	98	26	,	,	PUNCT
admet-553	98	27	in	in	ADP
admet-553	98	28	contrast	contrast	NOUN
admet-553	98	29	to	to	ADP
admet-553	98	30	the	the	DET
admet-553	98	31	choline	choline	NOUN
admet-553	98	32	nitrogen	nitrogen	NOUN
admet-553	98	33	which	which	PRON
admet-553	98	34	is	be	AUX
admet-553	98	35	more	more	ADV
admet-553	98	36	exposed	expose	VERB
admet-553	98	37	to	to	ADP
admet-553	98	38	the	the	DET
admet-553	98	39	solvent	solvent	ADJ
admet-553	98	40	effect	effect	NOUN
admet-553	98	41	at	at	ADP
admet-553	98	42	the	the	DET
admet-553	98	43	outer	outer	ADJ
admet-553	98	44	terminal	terminal	NOUN
admet-553	98	45	of	of	ADP
admet-553	98	46	the	the	DET
admet-553	98	47	iam	iam	PROPN
admet-553	98	48	surface	surface	NOUN
admet-553	98	49	[	[	X
admet-553	98	50	21,26	21,26	NOUN
admet-553	98	51	]	]	PUNCT
admet-553	98	52	.	.	PUNCT
admet-553	99	1	thus	thus	ADV
admet-553	99	2	,	,	PUNCT
admet-553	99	3	phosphate	phosphate	ADJ
admet-553	99	4	anions	anion	NOUN
admet-553	99	5	enhance	enhance	VERB
admet-553	99	6	the	the	DET
admet-553	99	7	partitioning	partitioning	NOUN
admet-553	99	8	of	of	ADP
admet-553	99	9	cations	cation	NOUN
admet-553	99	10	into	into	ADP
admet-553	99	11	the	the	DET
admet-553	99	12	iam	iam	PROPN
admet-553	99	13	stationary	stationary	ADJ
admet-553	99	14	phase	phase	NOUN
admet-553	99	15	by	by	ADP
admet-553	99	16	attraction	attraction	NOUN
admet-553	99	17	forces	force	NOUN
admet-553	99	18	,	,	PUNCT
admet-553	99	19	while	while	SCONJ
admet-553	99	20	as	as	SCONJ
admet-553	99	21	already	already	ADV
admet-553	99	22	commented	comment	VERB
admet-553	99	23	,	,	PUNCT
admet-553	99	24	repulsive	repulsive	ADJ
admet-553	99	25	forces	force	NOUN
admet-553	99	26	may	may	AUX
admet-553	99	27	occur	occur	VERB
admet-553	99	28	with	with	ADP
admet-553	99	29	anions	anion	NOUN
admet-553	99	30	[	[	X
admet-553	99	31	21,26	21,26	NUM
admet-553	99	32	]	]	X
admet-553	99	33	.	.	PUNCT
admet-553	100	1	however	however	ADV
admet-553	100	2	,	,	PUNCT
admet-553	100	3	in	in	ADP
admet-553	100	4	the	the	DET
admet-553	100	5	case	case	NOUN
admet-553	100	6	of	of	ADP
admet-553	100	7	very	very	ADV
admet-553	100	8	hydrophilic	hydrophilic	ADJ
admet-553	100	9	anions	anion	NOUN
admet-553	100	10	,	,	PUNCT
admet-553	100	11	partitioning	partition	VERB
admet-553	100	12	into	into	ADP
admet-553	100	13	the	the	DET
admet-553	100	14	hydrophobic	hydrophobic	NOUN
admet-553	100	15	core	core	NOUN
admet-553	100	16	may	may	AUX
admet-553	100	17	not	not	PART
admet-553	100	18	be	be	AUX
admet-553	100	19	the	the	DET
admet-553	100	20	determinant	determinant	ADJ
admet-553	100	21	factor	factor	NOUN
admet-553	100	22	and	and	CCONJ
admet-553	100	23	attraction	attraction	NOUN
admet-553	100	24	by	by	ADP
admet-553	100	25	the	the	DET
admet-553	100	26	positively	positively	ADV
admet-553	100	27	charged	charge	VERB
admet-553	100	28	choline	choline	NOUN
admet-553	100	29	nitrogen	nitrogen	NOUN
admet-553	100	30	becomes	become	VERB
admet-553	100	31	similarly	similarly	ADV
admet-553	100	32	important	important	ADJ
admet-553	100	33	.	.	PUNCT
admet-553	101	1	in	in	ADP
admet-553	101	2	such	such	ADJ
admet-553	101	3	cases	case	NOUN
admet-553	101	4	,	,	PUNCT
admet-553	101	5	retention	retention	NOUN
admet-553	101	6	is	be	AUX
admet-553	101	7	mainly	mainly	ADV
admet-553	101	8	governed	govern	VERB
admet-553	101	9	by	by	ADP
admet-553	101	10	electrostatic	electrostatic	ADJ
admet-553	101	11	interactions	interaction	NOUN
admet-553	101	12	[	[	X
admet-553	101	13	17	17	NUM
admet-553	101	14	]	]	PUNCT
admet-553	101	15	.	.	PUNCT
admet-553	102	1	comparative	comparative	ADJ
admet-553	102	2	block	block	NOUN
admet-553	102	3	relevance	relevance	NOUN
admet-553	102	4	analysis	analysis	NOUN
admet-553	102	5	of	of	ADP
admet-553	102	6	pls	pls	NOUN
admet-553	102	7	models	model	NOUN
admet-553	102	8	based	base	VERB
admet-553	102	9	on	on	ADP
admet-553	102	10	volsurf	volsurf	PROPN
admet-553	102	11	descriptors	descriptor	NOUN
admet-553	102	12	further	far	ADV
admet-553	102	13	supports	support	VERB
admet-553	102	14	the	the	DET
admet-553	102	15	similar	similar	ADJ
admet-553	102	16	information	information	NOUN
admet-553	102	17	content	content	NOUN
admet-553	102	18	of	of	ADP
admet-553	102	19	log	log	PROPN
admet-553	102	20	kw(iam	kw(iam	NOUN
admet-553	102	21	)	)	PUNCT
admet-553	102	22	and	and	CCONJ
admet-553	102	23	log	log	VERB
admet-553	102	24	p	p	NOUN
admet-553	102	25	for	for	ADP
admet-553	102	26	neutral	neutral	ADJ
admet-553	102	27	compounds	compound	NOUN
admet-553	102	28	.	.	PUNCT
admet-553	103	1	as	as	ADP
admet-553	103	2	for	for	ADP
admet-553	103	3	bases	basis	NOUN
admet-553	103	4	and	and	CCONJ
admet-553	103	5	acids	acid	VERB
admet-553	103	6	the	the	DET
admet-553	103	7	analysis	analysis	NOUN
admet-553	103	8	of	of	ADP
admet-553	103	9	log	log	NOUN
admet-553	103	10	kw(iam	kw(iam	NOUN
admet-553	103	11	)	)	PUNCT
admet-553	103	12	(	(	PUNCT
admet-553	103	13	and	and	CCONJ
admet-553	103	14	also	also	ADV
admet-553	103	15	of	of	ADP
admet-553	103	16	log	log	NOUN
admet-553	103	17	p	p	NOUN
admet-553	103	18	)	)	PUNCT
admet-553	103	19	generates	generate	VERB
admet-553	103	20	a	a	DET
admet-553	103	21	positive	positive	ADJ
admet-553	103	22	sign	sign	NOUN
admet-553	103	23	for	for	ADP
admet-553	103	24	the	the	DET
admet-553	103	25	block	block	NOUN
admet-553	103	26	of	of	ADP
admet-553	103	27	h	h	NOUN
admet-553	103	28	-	-	PUNCT
admet-553	103	29	bond	bond	NOUN
admet-553	103	30	donor	donor	NOUN
admet-553	103	31	(	(	PUNCT
admet-553	103	32	hbd	hbd	NOUN
admet-553	103	33	)	)	PUNCT
admet-553	103	34	properties	property	NOUN
admet-553	103	35	in	in	ADP
admet-553	103	36	accordance	accordance	NOUN
admet-553	103	37	with	with	ADP
admet-553	103	38	the	the	DET
admet-553	103	39	enhanced	enhanced	ADJ
admet-553	103	40	affinity	affinity	NOUN
admet-553	103	41	to	to	ADP
admet-553	103	42	the	the	DET
admet-553	103	43	iam	iam	PROPN
admet-553	103	44	stationary	stationary	ADJ
admet-553	103	45	phase	phase	NOUN
admet-553	103	46	,	,	PUNCT
admet-553	103	47	favoured	favour	VERB
admet-553	103	48	for	for	ADP
admet-553	103	49	cations	cation	NOUN
admet-553	103	50	over	over	ADP
admet-553	103	51	anions	anion	NOUN
admet-553	103	52	,	,	PUNCT
admet-553	103	53	while	while	SCONJ
admet-553	103	54	the	the	DET
admet-553	103	55	opposite	opposite	ADJ
admet-553	103	56	sign	sign	NOUN
admet-553	103	57	(	(	PUNCT
admet-553	103	58	negative	negative	ADJ
admet-553	103	59	)	)	PUNCT
admet-553	103	60	is	be	AUX
admet-553	103	61	observed	observe	VERB
admet-553	103	62	in	in	ADP
admet-553	103	63	the	the	DET
admet-553	103	64	log	log	NOUN
admet-553	103	65	d	d	PROPN
admet-553	103	66	model	model	NOUN
admet-553	104	1	[	[	X
admet-553	104	2	45	45	NUM
admet-553	104	3	]	]	PUNCT
admet-553	104	4	.	.	PUNCT
admet-553	105	1	f.	f.	PROPN
admet-553	105	2	tsopelas	tsopelas	PROPN
admet-553	105	3	,	,	PUNCT
admet-553	105	4	c.	c.	PROPN
admet-553	105	5	stergiopoulos	stergiopoulos	PROPN
admet-553	105	6	,	,	PUNCT
admet-553	105	7	a.	a.	NOUN
admet-553	105	8	tsantili	tsantili	NOUN
admet-553	105	9	-	-	PUNCT
admet-553	105	10	kakoulidou	kakoulidou	NOUN
admet-553	105	11	admet	admet	PROPN
admet-553	105	12	&	&	CCONJ
admet-553	105	13	dmpk	dmpk	PROPN
admet-553	105	14	6(3	6(3	PROPN
admet-553	105	15	)	)	PUNCT
admet-553	105	16	(	(	PUNCT
admet-553	105	17	2018	2018	NUM
admet-553	105	18	)	)	PUNCT
admet-553	105	19	225	225	NUM
admet-553	105	20	-	-	SYM
admet-553	105	21	241	241	NUM
admet-553	105	22	230	230	NUM
admet-553	105	23	the	the	DET
admet-553	105	24	contribution	contribution	NOUN
admet-553	105	25	of	of	ADP
admet-553	105	26	hydrogen	hydrogen	NOUN
admet-553	105	27	bonding	bonding	NOUN
admet-553	105	28	has	have	AUX
admet-553	105	29	also	also	ADV
admet-553	105	30	been	be	AUX
admet-553	105	31	reported	report	VERB
admet-553	105	32	[	[	X
admet-553	105	33	7,25,31,34	7,25,31,34	NUM
admet-553	105	34	]	]	X
admet-553	105	35	and	and	CCONJ
admet-553	105	36	barbato	barbato	NOUN
admet-553	106	1	[	[	X
admet-553	106	2	46	46	NUM
admet-553	106	3	]	]	PUNCT
admet-553	106	4	has	have	AUX
admet-553	106	5	discussed	discuss	VERB
admet-553	106	6	the	the	DET
admet-553	106	7	role	role	NOUN
admet-553	106	8	of	of	ADP
admet-553	106	9	glycerol	glycerol	NOUN
admet-553	106	10	as	as	ADP
admet-553	106	11	a	a	DET
admet-553	106	12	hydrogen	hydrogen	NOUN
admet-553	106	13	acceptor	acceptor	NOUN
admet-553	106	14	in	in	ADP
admet-553	106	15	solute	solute	ADJ
admet-553	106	16	retention	retention	NOUN
admet-553	106	17	.	.	PUNCT
admet-553	107	1	this	this	PRON
admet-553	107	2	may	may	AUX
admet-553	107	3	be	be	AUX
admet-553	107	4	the	the	DET
admet-553	107	5	reason	reason	NOUN
admet-553	107	6	for	for	ADP
admet-553	107	7	only	only	ADV
admet-553	107	8	the	the	DET
admet-553	107	9	moderate	moderate	ADJ
admet-553	107	10	interrelation	interrelation	NOUN
admet-553	107	11	between	between	ADP
admet-553	107	12	log	log	NOUN
admet-553	107	13	kw(iam	kw(iam	NOUN
admet-553	107	14	)	)	PUNCT
admet-553	107	15	on	on	ADP
admet-553	107	16	the	the	DET
admet-553	107	17	two	two	NUM
admet-553	107	18	columns	column	NOUN
admet-553	107	19	,	,	PUNCT
admet-553	107	20	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	107	21	and	and	CCONJ
admet-553	107	22	iam.pc.mg	iam.pc.mg	PROPN
admet-553	107	23	obtained	obtain	VERB
admet-553	107	24	for	for	ADP
admet-553	107	25	a	a	DET
admet-553	107	26	set	set	NOUN
admet-553	107	27	of	of	ADP
admet-553	107	28	41	41	NUM
admet-553	107	29	flavonoids	flavonoid	NOUN
admet-553	107	30	,	,	PUNCT
admet-553	107	31	mainly	mainly	ADV
admet-553	107	32	as	as	ADP
admet-553	107	33	a	a	DET
admet-553	107	34	result	result	NOUN
admet-553	107	35	of	of	ADP
admet-553	107	36	their	their	PRON
admet-553	107	37	different	different	ADJ
admet-553	107	38	content	content	NOUN
admet-553	107	39	in	in	ADP
admet-553	107	40	alcoholic	alcoholic	ADJ
admet-553	107	41	hydroxyl	hydroxyl	NOUN
admet-553	107	42	groups	group	NOUN
admet-553	107	43	[	[	X
admet-553	107	44	20	20	NUM
admet-553	107	45	]	]	PUNCT
admet-553	107	46	.	.	PUNCT
admet-553	108	1	the	the	DET
admet-553	108	2	polar	polar	ADJ
admet-553	108	3	/	/	SYM
admet-553	108	4	electrostatic	electrostatic	ADJ
admet-553	108	5	interactions	interaction	NOUN
admet-553	108	6	can	can	AUX
admet-553	108	7	be	be	AUX
admet-553	108	8	expressed	express	VERB
admet-553	108	9	as	as	ADP
admet-553	108	10	(	(	PUNCT
admet-553	108	11	δlog	δlog	NOUN
admet-553	108	12	kw(iam	kw(iam	NOUN
admet-553	108	13	)	)	PUNCT
admet-553	108	14	)	)	PUNCT
admet-553	108	15	,	,	PUNCT
admet-553	108	16	which	which	PRON
admet-553	108	17	is	be	AUX
admet-553	108	18	the	the	DET
admet-553	108	19	difference	difference	NOUN
admet-553	108	20	between	between	ADP
admet-553	108	21	the	the	DET
admet-553	108	22	experimental	experimental	ADJ
admet-553	108	23	log	log	NOUN
admet-553	108	24	kw(iam	kw(iam	NOUN
admet-553	108	25	)	)	PUNCT
admet-553	108	26	value	value	NOUN
admet-553	108	27	and	and	CCONJ
admet-553	108	28	the	the	DET
admet-553	108	29	log	log	NOUN
admet-553	108	30	kw(iam	kw(iam	NOUN
admet-553	108	31	)	)	PUNCT
admet-553	108	32	estimated	estimate	VERB
admet-553	108	33	by	by	ADP
admet-553	108	34	a	a	DET
admet-553	108	35	calibration	calibration	NOUN
admet-553	108	36	equation	equation	NOUN
admet-553	108	37	of	of	ADP
admet-553	108	38	log	log	PROPN
admet-553	108	39	kw(iam	kw(iam	NOUN
admet-553	108	40	)	)	PUNCT
admet-553	108	41	versus	versus	ADP
admet-553	108	42	log	log	VERB
admet-553	108	43	p	p	X
admet-553	108	44	,	,	PUNCT
admet-553	108	45	which	which	PRON
admet-553	108	46	is	be	AUX
admet-553	108	47	obtained	obtain	VERB
admet-553	108	48	for	for	ADP
admet-553	108	49	neutral	neutral	ADJ
admet-553	108	50	compounds	compound	NOUN
admet-553	108	51	,	,	PUNCT
admet-553	108	52	interacting	interact	VERB
admet-553	108	53	with	with	ADP
admet-553	108	54	the	the	DET
admet-553	108	55	iam	iam	PROPN
admet-553	108	56	stationary	stationary	ADJ
admet-553	108	57	phase	phase	NOUN
admet-553	108	58	by	by	ADP
admet-553	108	59	a	a	DET
admet-553	108	60	purely	purely	ADV
admet-553	108	61	hydrophobic	hydrophobic	ADJ
admet-553	108	62	mechanism	mechanism	NOUN
admet-553	108	63	.	.	PUNCT
admet-553	109	1	δlog	δlog	PROPN
admet-553	109	2	kw(iam	kw(iam	PROPN
admet-553	109	3	)	)	PUNCT
admet-553	109	4	is	be	AUX
admet-553	109	5	higher	high	ADJ
admet-553	109	6	for	for	ADP
admet-553	109	7	poorly	poorly	ADV
admet-553	109	8	lipophilic	lipophilic	ADJ
admet-553	109	9	compounds	compound	NOUN
admet-553	109	10	,	,	PUNCT
admet-553	109	11	while	while	SCONJ
admet-553	109	12	high	high	ADJ
admet-553	109	13	lipophilicity	lipophilicity	NOUN
admet-553	109	14	produces	produce	VERB
admet-553	109	15	negative	negative	ADJ
admet-553	109	16	values	value	NOUN
admet-553	109	17	[	[	X
admet-553	109	18	16,18,19,25	16,18,19,25	NUM
admet-553	109	19	]	]	PUNCT
admet-553	109	20	.	.	PUNCT
admet-553	110	1	as	as	SCONJ
admet-553	110	2	confirmed	confirm	VERB
admet-553	110	3	also	also	ADV
admet-553	110	4	by	by	ADP
admet-553	110	5	block	block	NOUN
admet-553	110	6	relevance	relevance	NOUN
admet-553	110	7	analysis	analysis	NOUN
admet-553	110	8	at	at	ADP
admet-553	110	9	least	least	ADJ
admet-553	110	10	for	for	ADP
admet-553	110	11	neutral	neutral	ADJ
admet-553	110	12	compounds	compound	NOUN
admet-553	110	13	,	,	PUNCT
admet-553	110	14	δlog	δlog	NOUN
admet-553	110	15	kw(iam	kw(iam	NOUN
admet-553	110	16	)	)	PUNCT
admet-553	110	17	is	be	AUX
admet-553	110	18	considered	consider	VERB
admet-553	110	19	as	as	ADP
admet-553	110	20	a	a	DET
admet-553	110	21	polarity	polarity	NOUN
admet-553	110	22	index	index	NOUN
admet-553	110	23	,	,	PUNCT
admet-553	110	24	which	which	PRON
admet-553	110	25	can	can	AUX
admet-553	110	26	be	be	AUX
admet-553	110	27	used	use	VERB
admet-553	110	28	in	in	ADP
admet-553	110	29	qspr	qspr	NOUN
admet-553	110	30	studies	study	NOUN
admet-553	110	31	replacing	replace	VERB
admet-553	110	32	other	other	ADJ
admet-553	110	33	polarity	polarity	NOUN
admet-553	110	34	parameters	parameter	NOUN
admet-553	110	35	such	such	ADJ
admet-553	110	36	as	as	ADP
admet-553	110	37	polar	polar	ADJ
admet-553	110	38	surface	surface	NOUN
admet-553	110	39	area	area	NOUN
admet-553	110	40	(	(	PUNCT
admet-553	110	41	psa	psa	NOUN
admet-553	110	42	)	)	PUNCT
admet-553	110	43	or	or	CCONJ
admet-553	110	44	δlog	δlog	PROPN
admet-553	110	45	poct	poct	NOUN
admet-553	110	46	-	-	PUNCT
admet-553	110	47	alk	alk	NOUN
admet-553	111	1	[	[	X
admet-553	111	2	45	45	NUM
admet-553	111	3	]	]	PUNCT
admet-553	111	4	.	.	PUNCT
admet-553	112	1	recently	recently	ADV
admet-553	112	2	,	,	PUNCT
admet-553	112	3	the	the	DET
admet-553	112	4	contribution	contribution	NOUN
admet-553	112	5	of	of	ADP
admet-553	112	6	secondary	secondary	ADJ
admet-553	112	7	interactions	interaction	NOUN
admet-553	112	8	due	due	ADP
admet-553	112	9	to	to	ADP
admet-553	112	10	residual	residual	ADJ
admet-553	112	11	silanol	silanol	NOUN
admet-553	112	12	and	and	CCONJ
admet-553	112	13	propylamine	propylamine	ADJ
admet-553	112	14	groups	group	NOUN
admet-553	112	15	to	to	ADP
admet-553	112	16	the	the	DET
admet-553	112	17	elution	elution	NOUN
admet-553	112	18	mechanism	mechanism	NOUN
admet-553	112	19	on	on	ADP
admet-553	112	20	iam	iam	PROPN
admet-553	112	21	stationary	stationary	ADJ
admet-553	112	22	phases	phase	NOUN
admet-553	112	23	has	have	AUX
admet-553	112	24	been	be	AUX
admet-553	112	25	investigated	investigate	VERB
admet-553	112	26	.	.	PUNCT
admet-553	113	1	such	such	ADJ
admet-553	113	2	secondary	secondary	ADJ
admet-553	113	3	interactions	interaction	NOUN
admet-553	113	4	are	be	AUX
admet-553	113	5	attributed	attribute	VERB
admet-553	113	6	to	to	ADP
admet-553	113	7	the	the	DET
admet-553	113	8	change	change	NOUN
admet-553	113	9	of	of	ADP
admet-553	113	10	the	the	DET
admet-553	113	11	net	net	ADJ
admet-553	113	12	charge	charge	NOUN
admet-553	113	13	of	of	ADP
admet-553	113	14	the	the	DET
admet-553	113	15	iam	iam	PROPN
admet-553	113	16	surface	surface	NOUN
admet-553	113	17	as	as	ADP
admet-553	113	18	a	a	DET
admet-553	113	19	function	function	NOUN
admet-553	113	20	of	of	ADP
admet-553	113	21	ph	ph	PROPN
admet-553	113	22	.	.	PROPN
admet-553	113	23	at	at	ADP
admet-553	113	24	ph	ph	PROPN
admet-553	113	25	>	>	X
admet-553	113	26	5	5	NUM
admet-553	113	27	there	there	PRON
admet-553	113	28	is	be	VERB
admet-553	113	29	an	an	DET
admet-553	113	30	overall	overall	ADJ
admet-553	113	31	negative	negative	ADJ
admet-553	113	32	charge	charge	NOUN
admet-553	113	33	on	on	ADP
admet-553	113	34	the	the	DET
admet-553	113	35	iam	iam	PROPN
admet-553	113	36	surface	surface	NOUN
admet-553	113	37	due	due	ADP
admet-553	113	38	to	to	ADP
admet-553	113	39	the	the	DET
admet-553	113	40	predominance	predominance	NOUN
admet-553	113	41	of	of	ADP
admet-553	113	42	ionized	ionized	ADJ
admet-553	113	43	silanol	silanol	NOUN
admet-553	113	44	groups	group	NOUN
admet-553	113	45	,	,	PUNCT
admet-553	113	46	while	while	SCONJ
admet-553	113	47	at	at	ADP
admet-553	113	48	lower	low	ADJ
admet-553	113	49	ph	ph	ADJ
admet-553	113	50	protonated	protonate	VERB
admet-553	113	51	propylamine	propylamine	NOUN
admet-553	113	52	groups	group	NOUN
admet-553	113	53	prevail	prevail	VERB
admet-553	113	54	resulting	result	VERB
admet-553	113	55	in	in	ADP
admet-553	113	56	a	a	DET
admet-553	113	57	positive	positive	ADJ
admet-553	113	58	charge	charge	NOUN
admet-553	113	59	.	.	PUNCT
admet-553	114	1	hence	hence	ADV
admet-553	114	2	,	,	PUNCT
admet-553	114	3	at	at	ADP
admet-553	114	4	physiological	physiological	ADJ
admet-553	114	5	conditions	condition	NOUN
admet-553	114	6	,	,	PUNCT
admet-553	114	7	an	an	DET
admet-553	114	8	increased	increase	VERB
admet-553	114	9	retention	retention	NOUN
admet-553	114	10	capacity	capacity	NOUN
admet-553	114	11	of	of	ADP
admet-553	114	12	protonated	protonate	VERB
admet-553	114	13	bases	basis	NOUN
admet-553	114	14	can	can	AUX
admet-553	114	15	be	be	AUX
admet-553	114	16	anticipated	anticipate	VERB
admet-553	114	17	and	and	CCONJ
admet-553	114	18	therefore	therefore	ADV
admet-553	114	19	,	,	PUNCT
admet-553	114	20	an	an	DET
admet-553	114	21	overestimation	overestimation	NOUN
admet-553	114	22	of	of	ADP
admet-553	114	23	the	the	DET
admet-553	114	24	affinity	affinity	NOUN
admet-553	114	25	of	of	ADP
admet-553	114	26	such	such	ADJ
admet-553	114	27	compounds	compound	NOUN
admet-553	114	28	to	to	ADP
admet-553	114	29	phospholipids	phospholipid	NOUN
admet-553	114	30	.	.	PUNCT
admet-553	115	1	the	the	DET
admet-553	115	2	resulting	result	VERB
admet-553	115	3	electrostatic	electrostatic	ADJ
admet-553	115	4	effect	effect	NOUN
admet-553	115	5	is	be	AUX
admet-553	115	6	more	more	ADV
admet-553	115	7	pronounced	pronounced	ADJ
admet-553	115	8	in	in	ADP
admet-553	115	9	low	low	ADJ
admet-553	115	10	salinities	salinity	NOUN
admet-553	115	11	of	of	ADP
admet-553	115	12	eluents	eluent	NOUN
admet-553	115	13	[	[	X
admet-553	115	14	47	47	NUM
admet-553	115	15	]	]	PUNCT
admet-553	115	16	.	.	PUNCT
admet-553	116	1	the	the	DET
admet-553	116	2	role	role	NOUN
admet-553	116	3	of	of	ADP
admet-553	116	4	silanophilic	silanophilic	ADJ
admet-553	116	5	interactions	interaction	NOUN
admet-553	116	6	in	in	ADP
admet-553	116	7	iam	iam	PROPN
admet-553	116	8	retention	retention	NOUN
admet-553	116	9	has	have	AUX
admet-553	116	10	also	also	ADV
admet-553	116	11	been	be	AUX
admet-553	116	12	reported	report	VERB
admet-553	116	13	by	by	ADP
admet-553	116	14	other	other	ADJ
admet-553	116	15	authors	author	NOUN
admet-553	116	16	[	[	X
admet-553	116	17	30,34,38	30,34,38	NUM
admet-553	116	18	]	]	PUNCT
admet-553	116	19	.	.	PUNCT
admet-553	117	1	the	the	DET
admet-553	117	2	identification	identification	NOUN
admet-553	117	3	of	of	ADP
admet-553	117	4	the	the	DET
admet-553	117	5	molecular	molecular	ADJ
admet-553	117	6	factors	factor	NOUN
admet-553	117	7	expressed	express	VERB
admet-553	117	8	in	in	ADP
admet-553	117	9	iam	iam	PROPN
admet-553	117	10	retention	retention	NOUN
admet-553	117	11	has	have	AUX
admet-553	117	12	provided	provide	VERB
admet-553	117	13	tools	tool	NOUN
admet-553	117	14	for	for	ADP
admet-553	117	15	in	in	ADP
admet-553	117	16	silico	silico	NOUN
admet-553	117	17	prediction	prediction	NOUN
admet-553	117	18	of	of	ADP
admet-553	117	19	phospholipophilicity	phospholipophilicity	NOUN
admet-553	117	20	.	.	PUNCT
admet-553	118	1	ledbetter	ledbetter	PROPN
admet-553	118	2	et	et	PROPN
admet-553	118	3	al	al	PROPN
admet-553	118	4	.	.	PUNCT
admet-553	119	1	[	[	X
admet-553	119	2	48	48	NUM
admet-553	119	3	]	]	PUNCT
admet-553	119	4	developed	develop	VERB
admet-553	119	5	an	an	DET
admet-553	119	6	algorithm	algorithm	NOUN
admet-553	119	7	for	for	ADP
admet-553	119	8	the	the	DET
admet-553	119	9	prediction	prediction	NOUN
admet-553	119	10	of	of	ADP
admet-553	119	11	log	log	PROPN
admet-553	119	12	kw(iam	kw(iam	NOUN
admet-553	119	13	)	)	PUNCT
admet-553	119	14	values	value	NOUN
admet-553	119	15	of	of	ADP
admet-553	119	16	compounds	compound	NOUN
admet-553	119	17	based	base	VERB
admet-553	119	18	on	on	ADP
admet-553	119	19	fragments	fragment	NOUN
admet-553	119	20	and	and	CCONJ
admet-553	119	21	correction	correction	NOUN
admet-553	119	22	factors	factor	NOUN
admet-553	119	23	using	use	VERB
admet-553	119	24	a	a	DET
admet-553	119	25	data	data	NOUN
admet-553	119	26	set	set	VERB
admet-553	119	27	which	which	PRON
admet-553	119	28	consisted	consist	VERB
admet-553	119	29	of	of	ADP
admet-553	119	30	22	22	NUM
admet-553	119	31	aliphatic	aliphatic	ADJ
admet-553	119	32	and	and	CCONJ
admet-553	119	33	42	42	NUM
admet-553	119	34	aromatic	aromatic	ADJ
admet-553	119	35	compounds	compound	NOUN
admet-553	119	36	.	.	PUNCT
admet-553	120	1	recently	recently	ADV
admet-553	120	2	,	,	PUNCT
admet-553	120	3	russo	russo	PROPN
admet-553	120	4	et	et	PROPN
admet-553	120	5	al	al	PROPN
admet-553	120	6	.	.	PUNCT
admet-553	121	1	[	[	X
admet-553	121	2	27	27	NUM
admet-553	121	3	]	]	PUNCT
admet-553	121	4	proposed	propose	VERB
admet-553	121	5	a	a	DET
admet-553	121	6	model	model	NOUN
admet-553	121	7	for	for	ADP
admet-553	121	8	prediction	prediction	NOUN
admet-553	121	9	of	of	ADP
admet-553	121	10	log	log	PROPN
admet-553	121	11	kw(iam	kw(iam	NOUN
admet-553	121	12	)	)	PUNCT
admet-553	121	13	values	value	NOUN
admet-553	121	14	,	,	PUNCT
admet-553	121	15	involving	involve	VERB
admet-553	121	16	four	four	NUM
admet-553	121	17	in	in	ADP
admet-553	121	18	silico	silico	NOUN
admet-553	121	19	calculated	calculate	VERB
admet-553	121	20	parameters	parameter	NOUN
admet-553	121	21	;	;	PUNCT
admet-553	121	22	lipophilicity	lipophilicity	NOUN
admet-553	121	23	,	,	PUNCT
admet-553	121	24	hydrophilic/	hydrophilic/	NUM
admet-553	121	25	lipophilic	lipophilic	ADJ
admet-553	121	26	balance	balance	NOUN
admet-553	121	27	,	,	PUNCT
admet-553	121	28	molecular	molecular	ADJ
admet-553	121	29	size	size	NOUN
admet-553	121	30	and	and	CCONJ
admet-553	121	31	molecular	molecular	ADJ
admet-553	121	32	flexibility	flexibility	NOUN
admet-553	121	33	.	.	PUNCT
admet-553	122	1	the	the	DET
admet-553	122	2	work	work	NOUN
admet-553	122	3	was	be	AUX
admet-553	122	4	based	base	VERB
admet-553	122	5	on	on	ADP
admet-553	122	6	their	their	PRON
admet-553	122	7	measurements	measurement	NOUN
admet-553	122	8	on	on	ADP
admet-553	122	9	205	205	NUM
admet-553	122	10	experimental	experimental	ADJ
admet-553	122	11	values	value	NOUN
admet-553	122	12	made	make	VERB
admet-553	122	13	by	by	ADP
admet-553	122	14	them	they	PRON
admet-553	122	15	on	on	ADP
admet-553	122	16	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	122	17	and	and	CCONJ
admet-553	122	18	iam.pc.mg	iam.pc.mg	PROPN
admet-553	122	19	column	column	NOUN
admet-553	122	20	types	type	NOUN
admet-553	122	21	,	,	PUNCT
admet-553	122	22	to	to	PART
admet-553	122	23	minimize	minimize	VERB
admet-553	122	24	inter	inter	ADJ
admet-553	122	25	-	-	ADJ
admet-553	122	26	laboratory	laboratory	ADJ
admet-553	122	27	variability	variability	NOUN
admet-553	122	28	,	,	PUNCT
admet-553	122	29	leading	lead	VERB
admet-553	122	30	to	to	ADP
admet-553	122	31	a	a	DET
admet-553	122	32	good	good	ADJ
admet-553	122	33	degree	degree	NOUN
admet-553	122	34	of	of	ADP
admet-553	122	35	accuracy	accuracy	NOUN
admet-553	122	36	(	(	PUNCT
admet-553	122	37	r2=	r2=	PROPN
admet-553	122	38	0.85	0.85	NUM
admet-553	122	39	)	)	PUNCT
admet-553	122	40	.	.	PUNCT
admet-553	123	1	the	the	DET
admet-553	123	2	applications	application	NOUN
admet-553	123	3	of	of	ADP
admet-553	123	4	iam	iam	PROPN
admet-553	123	5	chromatography	chromatography	NOUN
admet-553	123	6	to	to	PART
admet-553	123	7	predict	predict	VERB
admet-553	123	8	admet	admet	NOUN
admet-553	123	9	properties	property	NOUN
admet-553	123	10	in	in	ADP
admet-553	123	11	pharmaceutical	pharmaceutical	ADJ
admet-553	123	12	sciences	science	NOUN
admet-553	123	13	interactions	interaction	NOUN
admet-553	123	14	between	between	ADP
admet-553	123	15	drugs	drug	NOUN
admet-553	123	16	and	and	CCONJ
admet-553	123	17	immobilized	immobilized	ADJ
admet-553	123	18	phospholipids	phospholipid	NOUN
admet-553	123	19	,	,	PUNCT
admet-553	123	20	expressed	express	VERB
admet-553	123	21	in	in	ADP
admet-553	123	22	iam	iam	PROPN
admet-553	123	23	retention	retention	NOUN
admet-553	123	24	,	,	PUNCT
admet-553	123	25	can	can	AUX
admet-553	123	26	serve	serve	VERB
admet-553	123	27	as	as	ADP
admet-553	123	28	important	important	ADJ
admet-553	123	29	indices	index	NOUN
admet-553	123	30	for	for	ADP
admet-553	123	31	various	various	ADJ
admet-553	123	32	processes	process	NOUN
admet-553	123	33	,	,	PUNCT
admet-553	123	34	such	such	ADJ
admet-553	123	35	as	as	ADP
admet-553	123	36	drug	drug	NOUN
admet-553	123	37	permeability	permeability	NOUN
admet-553	123	38	and	and	CCONJ
admet-553	123	39	absorption	absorption	NOUN
admet-553	123	40	(	(	PUNCT
admet-553	123	41	considering	consider	VERB
admet-553	123	42	passive	passive	ADJ
admet-553	123	43	diffusion	diffusion	NOUN
admet-553	123	44	as	as	ADP
admet-553	123	45	the	the	DET
admet-553	123	46	main	main	ADJ
admet-553	123	47	process	process	NOUN
admet-553	123	48	)	)	PUNCT
admet-553	123	49	,	,	PUNCT
admet-553	123	50	tissue	tissue	NOUN
admet-553	123	51	and	and	CCONJ
admet-553	123	52	subcellular	subcellular	ADJ
admet-553	123	53	distribution	distribution	NOUN
admet-553	123	54	as	as	ADV
admet-553	123	55	well	well	ADV
admet-553	123	56	as	as	ADP
admet-553	123	57	toxicity	toxicity	NOUN
admet-553	123	58	due	due	ADP
admet-553	123	59	to	to	ADP
admet-553	123	60	functional	functional	ADJ
admet-553	123	61	and	and	CCONJ
admet-553	123	62	morphological	morphological	ADJ
admet-553	123	63	changes	change	NOUN
admet-553	123	64	in	in	ADP
admet-553	123	65	cells	cell	NOUN
admet-553	123	66	as	as	ADP
admet-553	123	67	for	for	ADP
admet-553	123	68	instance	instance	NOUN
admet-553	123	69	phospholipidosis	phospholipidosis	NOUN
admet-553	123	70	.	.	PUNCT
admet-553	124	1	comparative	comparative	ADJ
admet-553	124	2	studies	study	NOUN
admet-553	124	3	have	have	AUX
admet-553	124	4	shown	show	VERB
admet-553	124	5	that	that	SCONJ
admet-553	124	6	iam	iam	PROPN
admet-553	124	7	retention	retention	NOUN
admet-553	124	8	factors	factor	NOUN
admet-553	124	9	correlate	correlate	VERB
admet-553	124	10	with	with	ADP
admet-553	124	11	caco-2	caco-2	NUM
admet-553	124	12	permeability	permeability	NOUN
admet-553	124	13	[	[	X
admet-553	124	14	49	49	NUM
admet-553	124	15	-	-	SYM
admet-553	124	16	51	51	NUM
admet-553	124	17	]	]	PUNCT
admet-553	124	18	or	or	CCONJ
admet-553	124	19	with	with	ADP
admet-553	124	20	permeability	permeability	NOUN
admet-553	124	21	through	through	ADP
admet-553	124	22	mdck	mdck	PROPN
admet-553	124	23	cell	cell	NOUN
admet-553	124	24	lines	line	NOUN
admet-553	124	25	,	,	PUNCT
admet-553	124	26	two	two	NUM
admet-553	124	27	standard	standard	ADJ
admet-553	124	28	protocols	protocol	NOUN
admet-553	124	29	which	which	PRON
admet-553	124	30	used	use	VERB
admet-553	124	31	to	to	PART
admet-553	124	32	measure	measure	VERB
admet-553	124	33	permeability	permeability	NOUN
admet-553	124	34	in	in	ADP
admet-553	124	35	vitro	vitro	X
admet-553	124	36	[	[	X
admet-553	124	37	17	17	NUM
admet-553	124	38	]	]	PUNCT
admet-553	124	39	.	.	PUNCT
admet-553	125	1	of	of	ADP
admet-553	125	2	significant	significant	ADJ
admet-553	125	3	importance	importance	NOUN
admet-553	125	4	are	be	AUX
admet-553	125	5	the	the	DET
admet-553	125	6	applications	application	NOUN
admet-553	125	7	of	of	ADP
admet-553	125	8	iam	iam	PROPN
admet-553	125	9	chromatography	chromatography	NOUN
admet-553	125	10	to	to	PART
admet-553	125	11	model	model	VERB
admet-553	125	12	gastrointestinal	gastrointestinal	ADJ
admet-553	125	13	absorption/	absorption/	NUM
admet-553	125	14	bioavailability	bioavailability	NOUN
admet-553	125	15	.	.	PUNCT
admet-553	126	1	it	it	PRON
admet-553	126	2	is	be	AUX
admet-553	126	3	known	know	VERB
admet-553	126	4	that	that	SCONJ
admet-553	126	5	passive	passive	ADJ
admet-553	126	6	permeation	permeation	NOUN
admet-553	126	7	routes	route	NOUN
admet-553	126	8	for	for	ADP
admet-553	126	9	drugs	drug	NOUN
admet-553	126	10	involve	involve	VERB
admet-553	126	11	diffusion	diffusion	NOUN
admet-553	126	12	through	through	ADP
admet-553	126	13	the	the	DET
admet-553	126	14	aqueous	aqueous	ADJ
admet-553	126	15	pores	pore	NOUN
admet-553	126	16	at	at	ADP
admet-553	126	17	the	the	DET
admet-553	126	18	tight	tight	ADJ
admet-553	126	19	junctions	junction	NOUN
admet-553	126	20	,	,	PUNCT
admet-553	126	21	the	the	DET
admet-553	126	22	so	so	ADV
admet-553	126	23	-	-	PUNCT
admet-553	126	24	called	call	VERB
admet-553	126	25	paracellular	paracellular	ADJ
admet-553	126	26	absorption	absorption	NOUN
admet-553	126	27	and	and	CCONJ
admet-553	126	28	transcellular	transcellular	NOUN
admet-553	126	29	absorption	absorption	NOUN
admet-553	126	30	through	through	ADP
admet-553	126	31	the	the	DET
admet-553	126	32	enterocyte	enterocyte	NOUN
admet-553	126	33	itself	itself	PRON
admet-553	127	1	[	[	X
admet-553	127	2	52	52	NUM
admet-553	127	3	]	]	PUNCT
admet-553	127	4	.	.	PUNCT
admet-553	128	1	published	publish	VERB
admet-553	128	2	investigations	investigation	NOUN
admet-553	128	3	have	have	AUX
admet-553	128	4	reported	report	VERB
admet-553	128	5	mainly	mainly	ADV
admet-553	128	6	the	the	DET
admet-553	128	7	establishment	establishment	NOUN
admet-553	128	8	of	of	ADP
admet-553	128	9	non	non	ADJ
admet-553	128	10	linear	linear	PROPN
admet-553	128	11	models	model	NOUN
admet-553	128	12	for	for	ADP
admet-553	128	13	transcellular	transcellular	NOUN
admet-553	128	14	based	base	VERB
admet-553	128	15	human	human	ADJ
admet-553	128	16	oral	oral	ADJ
admet-553	128	17	absorption	absorption	NOUN
admet-553	128	18	(	(	PUNCT
admet-553	128	19	hoa	hoa	NOUN
admet-553	128	20	)	)	PUNCT
admet-553	128	21	combining	combine	VERB
admet-553	128	22	iam	iam	PROPN
admet-553	128	23	retention	retention	NOUN
admet-553	128	24	with	with	ADP
admet-553	128	25	other	other	ADJ
admet-553	128	26	admet	admet	PROPN
admet-553	128	27	&	&	CCONJ
admet-553	128	28	dmpk	dmpk	PROPN
admet-553	128	29	6(3	6(3	PROPN
admet-553	128	30	)	)	PUNCT
admet-553	128	31	(	(	PUNCT
admet-553	128	32	2018	2018	NUM
admet-553	128	33	)	)	PUNCT
admet-553	128	34	225	225	NUM
admet-553	128	35	-	-	SYM
admet-553	128	36	241	241	NUM
admet-553	128	37	iam	iam	PROPN
admet-553	128	38	chromatography	chromatography	NOUN
admet-553	128	39	in	in	ADP
admet-553	128	40	medicinal	medicinal	ADJ
admet-553	128	41	chemistry	chemistry	NOUN
admet-553	128	42	and	and	CCONJ
admet-553	128	43	environment	environment	NOUN
admet-553	128	44	doi	doi	PROPN
admet-553	128	45	:	:	PUNCT
admet-553	128	46	10.5599	10.5599	NUM
admet-553	128	47	/	/	SYM
admet-553	128	48	admet.553	admet.553	NOUN
admet-553	128	49	231	231	NUM
admet-553	128	50	physicochemical	physicochemical	ADJ
admet-553	128	51	properties	property	NOUN
admet-553	128	52	,	,	PUNCT
admet-553	128	53	such	such	ADJ
admet-553	128	54	as	as	ADP
admet-553	128	55	molecular	molecular	ADJ
admet-553	128	56	weight	weight	NOUN
admet-553	128	57	(	(	PUNCT
admet-553	128	58	mw	mw	NOUN
admet-553	128	59	)	)	PUNCT
admet-553	128	60	or	or	CCONJ
admet-553	128	61	polarity	polarity	NOUN
admet-553	128	62	terms	term	NOUN
admet-553	128	63	.	.	PUNCT
admet-553	129	1	yoon	yoon	PROPN
admet-553	129	2	et	et	PROPN
admet-553	129	3	al	al	PROPN
admet-553	129	4	.	.	PROPN
admet-553	129	5	reported	report	VERB
admet-553	129	6	a	a	DET
admet-553	129	7	sigmoidal	sigmoidal	NOUN
admet-553	129	8	model	model	NOUN
admet-553	129	9	for	for	ADP
admet-553	129	10	a	a	DET
admet-553	129	11	data	datum	NOUN
admet-553	129	12	set	set	VERB
admet-553	129	13	of	of	ADP
admet-553	129	14	40	40	NUM
admet-553	129	15	structurally	structurally	ADV
admet-553	129	16	diverse	diverse	ADJ
admet-553	129	17	drugs	drug	NOUN
admet-553	130	1	[	[	X
admet-553	130	2	53	53	NUM
admet-553	130	3	]	]	PUNCT
admet-553	130	4	using	use	VERB
admet-553	130	5	isocratic	isocratic	ADJ
admet-553	130	6	retention	retention	NOUN
admet-553	130	7	factors	factor	NOUN
admet-553	130	8	corrected	correct	VERB
admet-553	130	9	with	with	ADP
admet-553	130	10	mw	mw	NOUN
admet-553	130	11	to	to	ADP
admet-553	130	12	the	the	DET
admet-553	130	13	nth	nth	NOUN
admet-553	130	14	power	power	NOUN
admet-553	130	15	.	.	PUNCT
admet-553	131	1	the	the	DET
admet-553	131	2	best	good	ADJ
admet-553	131	3	fit	fit	NOUN
admet-553	131	4	was	be	AUX
admet-553	131	5	obtained	obtain	VERB
admet-553	131	6	for	for	ADP
admet-553	131	7	k(iam	k(iam	PROPN
admet-553	131	8	)	)	PUNCT
admet-553	131	9	with	with	ADP
admet-553	131	10	n=2.5	n=2.5	NOUN
admet-553	131	11	.	.	PUNCT
admet-553	132	1	the	the	DET
admet-553	132	2	same	same	ADJ
admet-553	132	3	group	group	NOUN
admet-553	132	4	continued	continue	VERB
admet-553	132	5	their	their	PRON
admet-553	132	6	study	study	NOUN
admet-553	132	7	combining	combine	VERB
admet-553	132	8	iam	iam	PROPN
admet-553	132	9	retention	retention	NOUN
admet-553	132	10	with	with	ADP
admet-553	132	11	hepatic	hepatic	ADJ
admet-553	132	12	metabolic	metabolic	NOUN
admet-553	132	13	clearance	clearance	NOUN
admet-553	132	14	to	to	PART
admet-553	132	15	model	model	VERB
admet-553	132	16	the	the	DET
admet-553	132	17	oral	oral	ADJ
admet-553	132	18	absorption	absorption	NOUN
admet-553	132	19	potential	potential	NOUN
admet-553	132	20	for	for	ADP
admet-553	132	21	a	a	DET
admet-553	132	22	limited	limited	ADJ
admet-553	132	23	set	set	NOUN
admet-553	132	24	of	of	ADP
admet-553	132	25	15	15	NUM
admet-553	132	26	drugs	drug	NOUN
admet-553	132	27	[	[	X
admet-553	132	28	54	54	NUM
admet-553	132	29	]	]	PUNCT
admet-553	132	30	.	.	PUNCT
admet-553	133	1	yen	yen	NOUN
admet-553	133	2	et	et	PROPN
admet-553	133	3	al	al	PROPN
admet-553	133	4	.	.	PROPN
admet-553	133	5	reported	report	VERB
admet-553	133	6	a	a	DET
admet-553	133	7	reciprocal	reciprocal	ADJ
admet-553	133	8	correlation	correlation	NOUN
admet-553	133	9	between	between	ADP
admet-553	133	10	the	the	DET
admet-553	133	11	negative	negative	ADJ
admet-553	133	12	value	value	NOUN
admet-553	133	13	of	of	ADP
admet-553	133	14	the	the	DET
admet-553	133	15	iam	iam	PROPN
admet-553	133	16	retention	retention	NOUN
admet-553	133	17	factor	factor	NOUN
admet-553	133	18	(	(	PUNCT
admet-553	133	19	-1	-1	ADJ
admet-553	133	20	/	/	SYM
admet-553	133	21	k(iam	k(iam	PROPN
admet-553	133	22	)	)	PUNCT
admet-553	133	23	)	)	PUNCT
admet-553	134	1	and	and	CCONJ
admet-553	134	2	human	human	ADJ
admet-553	134	3	intestinal	intestinal	ADJ
admet-553	134	4	absorption	absorption	NOUN
admet-553	134	5	for	for	ADP
admet-553	134	6	52	52	NUM
admet-553	134	7	drugs	drug	NOUN
admet-553	134	8	(	(	PUNCT
admet-553	134	9	r=0.64	r=0.64	NOUN
admet-553	134	10	)	)	PUNCT
admet-553	134	11	.	.	PUNCT
admet-553	135	1	this	this	DET
admet-553	135	2	correlation	correlation	NOUN
admet-553	135	3	was	be	AUX
admet-553	135	4	further	far	ADV
admet-553	135	5	improved	improve	VERB
admet-553	135	6	upon	upon	SCONJ
admet-553	135	7	the	the	DET
admet-553	135	8	inclusion	inclusion	NOUN
admet-553	135	9	of	of	ADP
admet-553	135	10	molecular	molecular	ADJ
admet-553	135	11	descriptors	descriptor	NOUN
admet-553	135	12	expressing	express	VERB
admet-553	135	13	molecular	molecular	ADJ
admet-553	135	14	size	size	NOUN
admet-553	135	15	and	and	CCONJ
admet-553	135	16	shape	shape	NOUN
admet-553	135	17	,	,	PUNCT
admet-553	135	18	solubility	solubility	NOUN
admet-553	135	19	and	and	CCONJ
admet-553	135	20	polarity	polarity	NOUN
admet-553	135	21	(	(	PUNCT
admet-553	135	22	r=0.83	r=0.83	PROPN
admet-553	135	23	)	)	PUNCT
admet-553	136	1	[	[	X
admet-553	136	2	55	55	NUM
admet-553	136	3	]	]	PUNCT
admet-553	136	4	.	.	PUNCT
admet-553	136	5	kotecha	kotecha	PROPN
admet-553	136	6	et	et	PROPN
admet-553	136	7	al	al	PROPN
admet-553	136	8	.	.	PROPN
admet-553	136	9	suggested	suggest	VERB
admet-553	136	10	that	that	SCONJ
admet-553	136	11	as	as	SCONJ
admet-553	136	12	intestinal	intestinal	ADJ
admet-553	136	13	absorption	absorption	NOUN
admet-553	136	14	occurs	occur	VERB
admet-553	136	15	along	along	ADP
admet-553	136	16	the	the	DET
admet-553	136	17	gastrointestinal	gastrointestinal	ADJ
admet-553	136	18	tract	tract	NOUN
admet-553	136	19	and	and	CCONJ
admet-553	136	20	mainly	mainly	ADV
admet-553	136	21	in	in	ADP
admet-553	136	22	the	the	DET
admet-553	136	23	small	small	ADJ
admet-553	136	24	intestine	intestine	NOUN
admet-553	136	25	with	with	ADP
admet-553	136	26	a	a	DET
admet-553	136	27	ph	ph	ADJ
admet-553	136	28	gradient	gradient	NOUN
admet-553	136	29	,	,	PUNCT
admet-553	136	30	the	the	DET
admet-553	136	31	maximum	maximum	ADJ
admet-553	136	32	log	log	NOUN
admet-553	136	33	kw(iam	kw(iam	NOUN
admet-553	136	34	)	)	PUNCT
admet-553	136	35	,	,	PUNCT
admet-553	136	36	measured	measure	VERB
admet-553	136	37	in	in	ADP
admet-553	136	38	a	a	DET
admet-553	136	39	certain	certain	ADJ
admet-553	136	40	ph	ph	ADJ
admet-553	136	41	range	range	NOUN
admet-553	136	42	(	(	PUNCT
admet-553	136	43	e.g.	e.g.	ADV
admet-553	136	44	4.5	4.5	NUM
admet-553	136	45	-	-	SYM
admet-553	136	46	7.4	7.4	NUM
admet-553	136	47	)	)	PUNCT
admet-553	136	48	and	and	CCONJ
admet-553	136	49	defined	define	VERB
admet-553	136	50	as	as	ADP
admet-553	136	51	best	good	ADJ
admet-553	136	52	w(iam)log	w(iam)log	NOUN
admet-553	136	53	k	k	PROPN
admet-553	136	54	should	should	AUX
admet-553	136	55	be	be	AUX
admet-553	136	56	considered	consider	VERB
admet-553	136	57	[	[	PUNCT
admet-553	136	58	32,33	32,33	NUM
admet-553	136	59	]	]	PUNCT
admet-553	136	60	.	.	PUNCT
admet-553	137	1	the	the	DET
admet-553	137	2	general	general	ADJ
admet-553	137	3	model	model	NOUN
admet-553	137	4	proposed	propose	VERB
admet-553	137	5	by	by	ADP
admet-553	137	6	kotecha	kotecha	PROPN
admet-553	137	7	et	et	PROPN
admet-553	137	8	al	al	PROPN
admet-553	137	9	.	.	PROPN
admet-553	137	10	is	be	AUX
admet-553	137	11	a	a	DET
admet-553	137	12	sigmoidal	sigmoidal	NOUN
admet-553	137	13	function	function	NOUN
admet-553	137	14	of	of	ADP
admet-553	137	15	%	%	PROPN
admet-553	137	16	hoa	hoa	PROPN
admet-553	137	17	,	,	PUNCT
admet-553	137	18	which	which	PRON
admet-553	137	19	can	can	AUX
admet-553	137	20	be	be	AUX
admet-553	137	21	improved	improve	VERB
admet-553	137	22	by	by	ADP
admet-553	137	23	additional	additional	ADJ
admet-553	137	24	physicochemical	physicochemical	ADJ
admet-553	137	25	parameters	parameter	NOUN
admet-553	137	26	,	,	PUNCT
admet-553	137	27	leading	lead	VERB
admet-553	137	28	to	to	ADP
admet-553	137	29	the	the	DET
admet-553	137	30	general	general	NOUN
admet-553	137	31	eq	eq	PROPN
admet-553	137	32	.	.	PUNCT
admet-553	138	1	(	(	PUNCT
admet-553	138	2	10	10	NUM
admet-553	138	3	):	):	PUNCT
admet-553	138	4			PROPN
admet-553	138	5	α	α	PROPN
admet-553	139	1	+	+	CCONJ
admet-553	139	2	α	α	NUM
admet-553	139	3	×	×	NOUN
admet-553	139	4	x	x	INTJ
admet-553	140	1	+	+	NOUN
admet-553	140	2	α	α	NUM
admet-553	140	3	×	×	NOUN
admet-553	140	4	x	x	X
admet-553	140	5	+	+	PUNCT
admet-553	140	6	…	…	PUNCT
admet-553	140	7	+	+	NUM
admet-553	140	8	α	α	NOUN
admet-553	140	9	xn	xn	PROPN
admet-553	140	10	n1	n1	PROPN
admet-553	140	11	10	10	NUM
admet-553	140	12	2	2	NUM
admet-553	140	13	2	2	NUM
admet-553	140	14	100	100	NUM
admet-553	140	15	%	%	NOUN
admet-553	140	16	hoa	hoa	NOUN
admet-553	140	17	=	=	NOUN
admet-553	140	18	1	1	NUM
admet-553	141	1	+	+	NUM
admet-553	141	2	10	10	NUM
admet-553	141	3	(	(	PUNCT
admet-553	141	4	10	10	NUM
admet-553	141	5	)	)	PUNCT
admet-553	141	6	where	where	SCONJ
admet-553	141	7	x1	x1	PROPN
admet-553	141	8	stands	stand	VERB
admet-553	141	9	for	for	ADP
admet-553	141	10	best	good	ADJ
admet-553	141	11	w(iam)log	w(iam)log	PROPN
admet-553	141	12	k	k	PROPN
admet-553	141	13	,	,	PUNCT
admet-553	141	14	x2	x2	PROPN
admet-553	141	15	,	,	PUNCT
admet-553	141	16	x3	x3	ADJ
admet-553	141	17	,	,	PUNCT
admet-553	141	18	..	..	PUNCT
admet-553	141	19	xn	xn	PROPN
admet-553	141	20	are	be	AUX
admet-553	141	21	additional	additional	ADJ
admet-553	141	22	physicochemical	physicochemical	ADJ
admet-553	141	23	properties	property	NOUN
admet-553	141	24	and	and	CCONJ
admet-553	141	25	α0	α0	ADJ
admet-553	141	26	,	,	PUNCT
admet-553	141	27	α1	α1	PROPN
admet-553	141	28	,	,	PUNCT
admet-553	141	29	α2	α2	ADJ
admet-553	141	30	,	,	PUNCT
admet-553	141	31	..	..	PUNCT
admet-553	141	32	,	,	PUNCT
admet-553	141	33	αn	αn	NOUN
admet-553	141	34	are	be	AUX
admet-553	141	35	regression	regression	NOUN
admet-553	141	36	coefficients	coefficient	NOUN
admet-553	141	37	obtained	obtain	VERB
admet-553	141	38	by	by	ADP
admet-553	141	39	non	non	ADJ
admet-553	141	40	-	-	ADJ
admet-553	141	41	linear	linear	ADJ
admet-553	141	42	fitting	fitting	NOUN
admet-553	141	43	.	.	PUNCT
admet-553	142	1	the	the	DET
admet-553	142	2	best	good	ADJ
admet-553	142	3	model	model	NOUN
admet-553	142	4	for	for	ADP
admet-553	142	5	27	27	NUM
admet-553	142	6	structurally	structurally	ADV
admet-553	142	7	diverse	diverse	ADJ
admet-553	142	8	drugs	drug	NOUN
admet-553	142	9	was	be	AUX
admet-553	142	10	obtained	obtain	VERB
admet-553	142	11	using	use	VERB
admet-553	142	12	best	good	ADJ
admet-553	142	13	w(iam)log	w(iam)log	PROPN
admet-553	142	14	k	k	NOUN
admet-553	142	15	in	in	ADP
admet-553	142	16	combination	combination	NOUN
admet-553	142	17	with	with	ADP
admet-553	142	18	the	the	DET
admet-553	142	19	polar	polar	ADJ
admet-553	142	20	surface	surface	NOUN
admet-553	142	21	area	area	NOUN
admet-553	143	1	[	[	X
admet-553	143	2	33	33	NUM
admet-553	143	3	]	]	PUNCT
admet-553	143	4	.	.	PUNCT
admet-553	144	1	tsopelas	tsopela	NOUN
admet-553	144	2	et	et	PROPN
admet-553	144	3	al	al	PROPN
admet-553	144	4	.	.	PROPN
admet-553	144	5	used	use	VERB
admet-553	144	6	an	an	DET
admet-553	144	7	extended	extended	ADJ
admet-553	144	8	data	datum	NOUN
admet-553	144	9	set	set	VERB
admet-553	144	10	of	of	ADP
admet-553	144	11	85	85	NUM
admet-553	144	12	drugs	drug	NOUN
admet-553	144	13	to	to	PART
admet-553	144	14	fit	fit	VERB
admet-553	144	15	best	good	ADJ
admet-553	144	16	w(iam)log	w(iam)log	NOUN
admet-553	144	17	k	k	PROPN
admet-553	144	18	in	in	ADP
admet-553	144	19	eq	eq	ADP
admet-553	144	20	.	.	PUNCT
admet-553	145	1	(	(	PUNCT
admet-553	145	2	10	10	NUM
admet-553	145	3	)	)	PUNCT
admet-553	145	4	.	.	PUNCT
admet-553	146	1	they	they	PRON
admet-553	146	2	obtained	obtain	VERB
admet-553	146	3	successfully	successfully	ADV
admet-553	146	4	validated	validate	VERB
admet-553	146	5	models	model	NOUN
admet-553	146	6	by	by	ADP
admet-553	146	7	including	include	VERB
admet-553	146	8	mw	mw	PROPN
admet-553	146	9	,	,	PUNCT
admet-553	146	10	the	the	DET
admet-553	146	11	abraham	abraham	PROPN
admet-553	146	12	’s	’s	PART
admet-553	146	13	hydrogen	hydrogen	NOUN
admet-553	146	14	-	-	PUNCT
admet-553	146	15	bond	bond	NOUN
admet-553	146	16	acidity	acidity	NOUN
admet-553	146	17	parameter	parameter	NOUN
admet-553	146	18	(	(	PUNCT
admet-553	146	19	a	a	X
admet-553	146	20	)	)	PUNCT
admet-553	146	21	,	,	PUNCT
admet-553	146	22	both	both	CCONJ
admet-553	146	23	with	with	ADP
admet-553	146	24	a	a	DET
admet-553	146	25	negative	negative	ADJ
admet-553	146	26	sign	sign	NOUN
admet-553	146	27	,	,	PUNCT
admet-553	146	28	and	and	CCONJ
admet-553	146	29	the	the	DET
admet-553	146	30	negatively	negatively	ADV
admet-553	146	31	charged	charge	VERB
admet-553	146	32	molecular	molecular	ADJ
admet-553	146	33	fraction	fraction	NOUN
admet-553	146	34	with	with	ADP
admet-553	146	35	a	a	DET
admet-553	146	36	positive	positive	ADJ
admet-553	146	37	sign	sign	NOUN
admet-553	146	38	.	.	PUNCT
admet-553	147	1	if	if	SCONJ
admet-553	147	2	zwitterions	zwitterion	NOUN
admet-553	147	3	were	be	AUX
admet-553	147	4	excluded	exclude	VERB
admet-553	147	5	from	from	ADP
admet-553	147	6	the	the	DET
admet-553	147	7	data	datum	NOUN
admet-553	147	8	set	set	VERB
admet-553	147	9	the	the	DET
admet-553	147	10	model	model	NOUN
admet-553	147	11	will	will	AUX
admet-553	147	12	include	include	VERB
admet-553	147	13	mw	mw	X
admet-553	147	14	and	and	CCONJ
admet-553	147	15	positively	positively	ADV
admet-553	147	16	charged	charge	VERB
admet-553	147	17	molecular	molecular	ADJ
admet-553	147	18	fraction	fraction	NOUN
admet-553	147	19	(	(	PUNCT
admet-553	147	20	f+	f+	PROPN
admet-553	147	21	)	)	PUNCT
admet-553	147	22	,	,	PUNCT
admet-553	147	23	both	both	CCONJ
admet-553	147	24	with	with	ADP
admet-553	147	25	a	a	DET
admet-553	147	26	negative	negative	ADJ
admet-553	147	27	sign	sign	NOUN
admet-553	147	28	.	.	PUNCT
admet-553	148	1	the	the	DET
admet-553	148	2	negative	negative	ADJ
admet-553	148	3	sign	sign	NOUN
admet-553	148	4	of	of	ADP
admet-553	148	5	f	f	PROPN
admet-553	148	6	+	+	NUM
admet-553	148	7	indicates	indicate	VERB
admet-553	148	8	that	that	SCONJ
admet-553	148	9	electrostatic	electrostatic	ADJ
admet-553	148	10	interactions	interaction	NOUN
admet-553	148	11	with	with	ADP
admet-553	148	12	the	the	DET
admet-553	148	13	phosphate	phosphate	ADJ
admet-553	148	14	anions	anion	NOUN
admet-553	148	15	on	on	ADP
admet-553	148	16	the	the	DET
admet-553	148	17	iam	iam	PROPN
admet-553	148	18	surface	surface	NOUN
admet-553	148	19	are	be	AUX
admet-553	148	20	over	over	ADV
admet-553	148	21	expressed	express	VERB
admet-553	148	22	and	and	CCONJ
admet-553	148	23	may	may	AUX
admet-553	148	24	be	be	AUX
admet-553	148	25	associated	associate	VERB
admet-553	148	26	with	with	ADP
admet-553	148	27	the	the	DET
admet-553	148	28	binding	bind	VERB
admet-553	148	29	component	component	NOUN
admet-553	148	30	,	,	PUNCT
admet-553	148	31	reflecting	reflect	VERB
admet-553	148	32	drug	drug	NOUN
admet-553	148	33	-	-	PUNCT
admet-553	148	34	membrane	membrane	NOUN
admet-553	148	35	interactions	interaction	NOUN
admet-553	148	36	besides	besides	SCONJ
admet-553	148	37	membrane	membrane	NOUN
admet-553	148	38	permeability	permeability	NOUN
admet-553	148	39	.	.	PUNCT
admet-553	149	1	analogous	analogous	ADJ
admet-553	149	2	models	model	NOUN
admet-553	149	3	in	in	ADP
admet-553	149	4	terms	term	NOUN
admet-553	149	5	of	of	ADP
admet-553	149	6	statistics	statistic	NOUN
admet-553	149	7	and	and	CCONJ
admet-553	149	8	predictive	predictive	ADJ
admet-553	149	9	performance	performance	NOUN
admet-553	149	10	were	be	AUX
admet-553	149	11	obtained	obtain	VERB
admet-553	149	12	by	by	ADP
admet-553	149	13	replacing	replace	VERB
admet-553	149	14	the	the	DET
admet-553	149	15	iam	iam	PROPN
admet-553	149	16	retention	retention	NOUN
admet-553	149	17	factors	factor	NOUN
admet-553	149	18	with	with	ADP
admet-553	149	19	octanol	octanol	NOUN
admet-553	149	20	-	-	PUNCT
admet-553	149	21	water	water	NOUN
admet-553	149	22	distribution	distribution	NOUN
admet-553	149	23	coefficients	coefficient	NOUN
admet-553	149	24	.	.	PUNCT
admet-553	150	1	the	the	DET
admet-553	150	2	main	main	ADJ
admet-553	150	3	difference	difference	NOUN
admet-553	150	4	between	between	ADP
admet-553	150	5	the	the	DET
admet-553	150	6	two	two	NUM
admet-553	150	7	models	model	NOUN
admet-553	150	8	relies	rely	VERB
admet-553	150	9	on	on	ADP
admet-553	150	10	the	the	DET
admet-553	150	11	opposite	opposite	ADJ
admet-553	150	12	sign	sign	NOUN
admet-553	150	13	of	of	ADP
admet-553	150	14	the	the	DET
admet-553	150	15	f+	f+	ADJ
admet-553	150	16	parameter	parameter	NOUN
admet-553	150	17	(	(	PUNCT
admet-553	150	18	positive	positive	ADJ
admet-553	150	19	in	in	ADP
admet-553	150	20	the	the	DET
admet-553	150	21	log	log	NOUN
admet-553	150	22	dbest	db	ADJ
admet-553	150	23	model	model	NOUN
admet-553	150	24	,	,	PUNCT
admet-553	150	25	negative	negative	ADJ
admet-553	150	26	in	in	ADP
admet-553	150	27	the	the	DET
admet-553	150	28	iam	iam	PROPN
admet-553	150	29	model	model	NOUN
admet-553	150	30	)	)	PUNCT
admet-553	150	31	attraction	attraction	NOUN
admet-553	150	32	forces	force	NOUN
admet-553	150	33	to	to	ADP
admet-553	150	34	the	the	DET
admet-553	150	35	negatively	negatively	ADV
admet-553	150	36	charged	charge	VERB
admet-553	150	37	inner	inner	ADJ
admet-553	150	38	membrane	membrane	NOUN
admet-553	150	39	,	,	PUNCT
admet-553	150	40	which	which	PRON
admet-553	150	41	do	do	AUX
admet-553	150	42	play	play	VERB
admet-553	150	43	a	a	DET
admet-553	150	44	role	role	NOUN
admet-553	150	45	in	in	ADP
admet-553	150	46	absorption	absorption	NOUN
admet-553	150	47	but	but	CCONJ
admet-553	150	48	are	be	AUX
admet-553	150	49	not	not	PART
admet-553	150	50	expressed	express	VERB
admet-553	150	51	in	in	ADP
admet-553	150	52	the	the	DET
admet-553	150	53	octanol	octanol	NOUN
admet-553	150	54	-	-	PUNCT
admet-553	150	55	water	water	NOUN
admet-553	150	56	system	system	NOUN
admet-553	150	57	.	.	PUNCT
admet-553	151	1	in	in	ADP
admet-553	151	2	addition	addition	NOUN
admet-553	151	3	,	,	PUNCT
admet-553	151	4	the	the	DET
admet-553	151	5	hydrogen	hydrogen	NOUN
admet-553	151	6	bond	bond	NOUN
admet-553	151	7	acidity	acidity	NOUN
admet-553	151	8	a	a	PRON
admet-553	151	9	is	be	AUX
admet-553	151	10	statistically	statistically	ADV
admet-553	151	11	non	non	ADJ
admet-553	151	12	-	-	ADJ
admet-553	151	13	significant	significant	ADJ
admet-553	151	14	in	in	ADP
admet-553	151	15	the	the	DET
admet-553	151	16	log	log	NOUN
admet-553	151	17	dbest	db	ADJ
admet-553	151	18	model	model	NOUN
admet-553	151	19	[	[	X
admet-553	151	20	17	17	NUM
admet-553	151	21	]	]	PUNCT
admet-553	151	22	.	.	PUNCT
admet-553	152	1	iam	iam	PROPN
admet-553	152	2	retention	retention	NOUN
admet-553	152	3	factors	factor	NOUN
admet-553	152	4	have	have	AUX
admet-553	152	5	also	also	ADV
admet-553	152	6	served	serve	VERB
admet-553	152	7	to	to	PART
admet-553	152	8	model	model	VERB
admet-553	152	9	blood	blood	NOUN
admet-553	152	10	-	-	PUNCT
admet-553	152	11	brain	brain	NOUN
admet-553	152	12	barrier	barrier	NOUN
admet-553	152	13	(	(	PUNCT
admet-553	152	14	bbb	bbb	NOUN
admet-553	152	15	)	)	PUNCT
admet-553	152	16	penetration	penetration	NOUN
admet-553	152	17	in	in	ADP
admet-553	152	18	combination	combination	NOUN
admet-553	152	19	with	with	ADP
admet-553	152	20	other	other	ADJ
admet-553	152	21	physicochemical	physicochemical	ADJ
admet-553	152	22	parameters	parameter	NOUN
admet-553	152	23	such	such	ADJ
admet-553	152	24	as	as	ADP
admet-553	152	25	molecular	molecular	ADJ
admet-553	152	26	volume	volume	NOUN
admet-553	152	27	and	and	CCONJ
admet-553	152	28	structural	structural	ADJ
admet-553	152	29	indices	index	NOUN
admet-553	152	30	.	.	PUNCT
admet-553	153	1	in	in	ADP
admet-553	153	2	an	an	DET
admet-553	153	3	early	early	ADJ
admet-553	153	4	study	study	NOUN
admet-553	153	5	,	,	PUNCT
admet-553	153	6	the	the	DET
admet-553	153	7	performance	performance	NOUN
admet-553	153	8	of	of	ADP
admet-553	153	9	iam	iam	PROPN
admet-553	153	10	to	to	PART
admet-553	153	11	model	model	VERB
admet-553	153	12	bbb	bbb	PROPN
admet-553	153	13	penetration	penetration	NOUN
admet-553	153	14	(	(	PUNCT
admet-553	153	15	log	log	NOUN
admet-553	153	16	bb	bb	NOUN
admet-553	153	17	)	)	PUNCT
admet-553	153	18	was	be	AUX
admet-553	153	19	compared	compare	VERB
admet-553	153	20	with	with	ADP
admet-553	153	21	octanol	octanol	NOUN
admet-553	153	22	-	-	PUNCT
admet-553	153	23	water	water	NOUN
admet-553	153	24	partitioning	partitioning	NOUN
admet-553	153	25	.	.	PUNCT
admet-553	154	1	the	the	DET
admet-553	154	2	log	log	NOUN
admet-553	154	3	bb/	bb/	NOUN
admet-553	154	4	log	log	NOUN
admet-553	154	5	kw	kw	PROPN
admet-553	154	6	correlations	correlation	NOUN
admet-553	154	7	were	be	AUX
admet-553	154	8	slightly	slightly	ADV
admet-553	154	9	inferior	inferior	ADJ
admet-553	154	10	in	in	ADP
admet-553	154	11	terms	term	NOUN
admet-553	154	12	of	of	ADP
admet-553	154	13	statistics	statistic	NOUN
admet-553	154	14	when	when	SCONJ
admet-553	154	15	compared	compare	VERB
admet-553	154	16	to	to	ADP
admet-553	154	17	the	the	DET
admet-553	154	18	corresponding	corresponding	ADJ
admet-553	154	19	log	log	NOUN
admet-553	154	20	bb/	bb/	NOUN
admet-553	154	21	log	log	NOUN
admet-553	154	22	p	p	NOUN
admet-553	154	23	data	data	NOUN
admet-553	154	24	.	.	PUNCT
admet-553	155	1	molecular	molecular	ADJ
admet-553	155	2	volume	volume	NOUN
admet-553	155	3	was	be	AUX
admet-553	155	4	statistically	statistically	ADV
admet-553	155	5	significant	significant	ADJ
admet-553	155	6	with	with	ADP
admet-553	155	7	a	a	DET
admet-553	155	8	negative	negative	ADJ
admet-553	155	9	contribution	contribution	NOUN
admet-553	155	10	in	in	ADP
admet-553	155	11	both	both	DET
admet-553	155	12	models	model	NOUN
admet-553	155	13	[	[	X
admet-553	155	14	56	56	NUM
admet-553	155	15	]	]	PUNCT
admet-553	155	16	.	.	PUNCT
admet-553	156	1	reichel	reichel	PROPN
admet-553	156	2	and	and	CCONJ
admet-553	156	3	begley	begley	PROPN
admet-553	156	4	found	find	VERB
admet-553	156	5	a	a	DET
admet-553	156	6	significant	significant	ADJ
admet-553	156	7	correlation	correlation	NOUN
admet-553	156	8	between	between	ADP
admet-553	156	9	the	the	DET
admet-553	156	10	logarithm	logarithm	NOUN
admet-553	156	11	of	of	ADP
admet-553	156	12	brain	brain	NOUN
admet-553	156	13	uptake	uptake	ADJ
admet-553	156	14	indices	index	NOUN
admet-553	156	15	divided	divide	VERB
admet-553	156	16	by	by	ADP
admet-553	156	17	the	the	DET
admet-553	156	18	square	square	ADJ
admet-553	156	19	root	root	NOUN
admet-553	156	20	of	of	ADP
admet-553	156	21	the	the	DET
admet-553	156	22	molecular	molecular	ADJ
admet-553	156	23	weight	weight	NOUN
admet-553	156	24	(	(	PUNCT
admet-553	156	25	log	log	NOUN
admet-553	156	26	bui	bui	NOUN
admet-553	156	27	)	)	PUNCT
admet-553	156	28	of	of	ADP
admet-553	156	29	six	six	NUM
admet-553	156	30	biogenic	biogenic	ADJ
admet-553	156	31	amines	amine	NOUN
admet-553	156	32	with	with	ADP
admet-553	156	33	iam	iam	PROPN
admet-553	156	34	retention	retention	NOUN
admet-553	156	35	(	(	PUNCT
admet-553	156	36	r2=0,747	r2=0,747	PROPN
admet-553	156	37	)	)	PUNCT
admet-553	156	38	,	,	PUNCT
admet-553	156	39	although	although	SCONJ
admet-553	156	40	the	the	DET
admet-553	156	41	same	same	ADJ
admet-553	156	42	indices	index	NOUN
admet-553	156	43	for	for	ADP
admet-553	156	44	six	six	NUM
admet-553	156	45	steroids	steroid	NOUN
admet-553	156	46	correlated	correlate	VERB
admet-553	156	47	better	well	ADV
admet-553	156	48	with	with	ADP
admet-553	156	49	computational	computational	ADJ
admet-553	156	50	clogp	clogp	NOUN
admet-553	156	51	than	than	ADP
admet-553	156	52	with	with	ADP
admet-553	156	53	log	log	NOUN
admet-553	156	54	kw(iam	kw(iam	NOUN
admet-553	156	55	)	)	PUNCT
admet-553	156	56	(	(	PUNCT
admet-553	156	57	r2=	r2=	PROPN
admet-553	156	58	0.809	0.809	NUM
admet-553	156	59	and	and	CCONJ
admet-553	156	60	r2=	r2=	PROPN
admet-553	156	61	0.729	0.729	NUM
admet-553	156	62	,	,	PUNCT
admet-553	156	63	respectively	respectively	ADV
admet-553	156	64	)	)	PUNCT
admet-553	157	1	[	[	X
admet-553	157	2	57	57	NUM
admet-553	157	3	]	]	PUNCT
admet-553	157	4	.	.	PUNCT
admet-553	158	1	pehourcq	pehourcq	NOUN
admet-553	158	2	et	et	PROPN
admet-553	158	3	al	al	PROPN
admet-553	158	4	.	.	PROPN
admet-553	158	5	reported	report	VERB
admet-553	158	6	a	a	DET
admet-553	158	7	parabolic	parabolic	ADJ
admet-553	158	8	relationship	relationship	NOUN
admet-553	158	9	for	for	ADP
admet-553	158	10	the	the	DET
admet-553	158	11	diffusion	diffusion	NOUN
admet-553	158	12	of	of	ADP
admet-553	158	13	cerebrospinal	cerebrospinal	ADJ
admet-553	158	14	fluid	fluid	NOUN
admet-553	158	15	(	(	PUNCT
admet-553	158	16	csf	csf	NOUN
admet-553	158	17	)	)	PUNCT
admet-553	158	18	for	for	ADP
admet-553	158	19	a	a	DET
admet-553	158	20	set	set	NOUN
admet-553	158	21	of	of	ADP
admet-553	158	22	eight	eight	NUM
admet-553	158	23	amyl	amyl	NOUN
admet-553	158	24	propionate	propionate	ADJ
admet-553	158	25	non	non	ADJ
admet-553	158	26	-	-	ADJ
admet-553	158	27	steroidal	steroidal	ADJ
admet-553	158	28	anti	anti	ADJ
admet-553	158	29	-	-	ADJ
admet-553	158	30	inflammatory	inflammatory	ADJ
admet-553	158	31	drugs	drug	NOUN
admet-553	158	32	.	.	PUNCT
admet-553	159	1	the	the	DET
admet-553	159	2	inclusion	inclusion	NOUN
admet-553	159	3	of	of	ADP
admet-553	159	4	molecular	molecular	ADJ
admet-553	159	5	weight	weight	NOUN
admet-553	159	6	led	lead	VERB
admet-553	159	7	to	to	ADP
admet-553	159	8	an	an	DET
admet-553	159	9	improved	improved	ADJ
admet-553	159	10	model	model	NOUN
admet-553	159	11	[	[	X
admet-553	159	12	58	58	NUM
admet-553	159	13	]	]	PUNCT
admet-553	159	14	.	.	PUNCT
admet-553	160	1	grumetto	grumetto	PROPN
admet-553	160	2	et	et	PROPN
admet-553	160	3	al	al	PROPN
admet-553	160	4	.	.	PROPN
admet-553	160	5	established	establish	VERB
admet-553	160	6	also	also	ADV
admet-553	160	7	parabolic	parabolic	ADJ
admet-553	160	8	relationships	relationship	NOUN
admet-553	160	9	for	for	ADP
admet-553	160	10	the	the	DET
admet-553	160	11	bbb	bbb	PROPN
admet-553	160	12	passage	passage	NOUN
admet-553	160	13	for	for	ADP
admet-553	160	14	a	a	DET
admet-553	160	15	set	set	NOUN
admet-553	160	16	of	of	ADP
admet-553	160	17	14	14	NUM
admet-553	160	18	f.	f.	PROPN
admet-553	160	19	tsopelas	tsopelas	PROPN
admet-553	160	20	,	,	PUNCT
admet-553	160	21	c.	c.	PROPN
admet-553	160	22	stergiopoulos	stergiopoulos	PROPN
admet-553	160	23	,	,	PUNCT
admet-553	160	24	a.	a.	NOUN
admet-553	160	25	tsantili	tsantili	NOUN
admet-553	160	26	-	-	PUNCT
admet-553	160	27	kakoulidou	kakoulidou	NOUN
admet-553	160	28	admet	admet	PROPN
admet-553	160	29	&	&	CCONJ
admet-553	160	30	dmpk	dmpk	PROPN
admet-553	160	31	6(3	6(3	PROPN
admet-553	160	32	)	)	PUNCT
admet-553	160	33	(	(	PUNCT
admet-553	160	34	2018	2018	NUM
admet-553	160	35	)	)	PUNCT
admet-553	160	36	225	225	NUM
admet-553	160	37	-	-	SYM
admet-553	160	38	241	241	NUM
admet-553	160	39	232	232	NUM
admet-553	160	40	basic	basic	ADJ
admet-553	160	41	drugs	drug	NOUN
admet-553	160	42	with	with	ADP
admet-553	160	43	retention	retention	NOUN
admet-553	160	44	on	on	ADP
admet-553	160	45	either	either	DET
admet-553	160	46	iam.pc.mg	iam.pc.mg	PROPN
admet-553	160	47	or	or	CCONJ
admet-553	160	48	iam.pc.dd2	iam.pc.dd2	PROPN
admet-553	160	49	stationary	stationary	ADJ
admet-553	160	50	phases	phase	NOUN
admet-553	160	51	.	.	PUNCT
admet-553	161	1	however	however	ADV
admet-553	161	2	,	,	PUNCT
admet-553	161	3	the	the	DET
admet-553	161	4	better	well	ADJ
admet-553	161	5	model	model	NOUN
admet-553	161	6	obtained	obtain	VERB
admet-553	161	7	with	with	ADP
admet-553	161	8	log	log	NOUN
admet-553	161	9	p	p	PROPN
admet-553	161	10	directed	direct	VERB
admet-553	161	11	the	the	DET
admet-553	161	12	authors	author	NOUN
admet-553	161	13	to	to	PART
admet-553	161	14	use	use	VERB
admet-553	161	15	the	the	DET
admet-553	161	16	δlog	δlog	NOUN
admet-553	161	17	kw(iam	kw(iam	NOUN
admet-553	161	18	)	)	PUNCT
admet-553	161	19	parameter	parameter	NOUN
admet-553	161	20	,	,	PUNCT
admet-553	161	21	assuming	assume	VERB
admet-553	161	22	that	that	SCONJ
admet-553	161	23	the	the	DET
admet-553	161	24	electrostatic	electrostatic	ADJ
admet-553	161	25	interactions	interaction	NOUN
admet-553	161	26	were	be	AUX
admet-553	161	27	encoded	encode	VERB
admet-553	161	28	in	in	ADP
admet-553	161	29	the	the	DET
admet-553	161	30	iam	iam	PROPN
admet-553	161	31	retention	retention	NOUN
admet-553	161	32	as	as	ADP
admet-553	161	33	a	a	DET
admet-553	161	34	factor	factor	NOUN
admet-553	161	35	that	that	PRON
admet-553	161	36	hinders	hinder	VERB
admet-553	161	37	drugs	drug	NOUN
admet-553	161	38	from	from	ADP
admet-553	161	39	transmembrane	transmembrane	ADJ
admet-553	161	40	penetration	penetration	NOUN
admet-553	161	41	[	[	X
admet-553	161	42	59	59	NUM
admet-553	161	43	]	]	PUNCT
admet-553	161	44	.	.	PUNCT
admet-553	162	1	they	they	PRON
admet-553	162	2	established	establish	VERB
admet-553	162	3	significant	significant	ADJ
admet-553	162	4	linear	linear	ADJ
admet-553	162	5	negative	negative	ADJ
admet-553	162	6	log	log	NOUN
admet-553	162	7	bb/	bb/	NOUN
admet-553	162	8	δlog	δlog	PROPN
admet-553	162	9	kw(iam	kw(iam	PROPN
admet-553	162	10	)	)	PUNCT
admet-553	162	11	,	,	PUNCT
admet-553	162	12	which	which	PRON
admet-553	162	13	were	be	AUX
admet-553	162	14	confirmed	confirm	VERB
admet-553	162	15	for	for	ADP
admet-553	162	16	an	an	DET
admet-553	162	17	enlarged	enlarged	ADJ
admet-553	162	18	set	set	NOUN
admet-553	162	19	of	of	ADP
admet-553	162	20	40	40	NUM
admet-553	162	21	structurally	structurally	ADV
admet-553	162	22	diverse	diverse	ADJ
admet-553	162	23	drugs	drug	NOUN
admet-553	162	24	[	[	X
admet-553	162	25	25	25	NUM
admet-553	162	26	]	]	PUNCT
admet-553	162	27	.	.	PUNCT
admet-553	163	1	more	more	ADV
admet-553	163	2	recently	recently	ADV
admet-553	163	3	,	,	PUNCT
admet-553	163	4	they	they	PRON
admet-553	163	5	have	have	AUX
admet-553	163	6	proposed	propose	VERB
admet-553	163	7	a	a	DET
admet-553	163	8	partial	partial	ADJ
admet-553	163	9	least	least	ADJ
admet-553	163	10	square	square	ADJ
admet-553	163	11	(	(	PUNCT
admet-553	163	12	pls	pls	INTJ
admet-553	163	13	)	)	PUNCT
admet-553	163	14	model	model	NOUN
admet-553	163	15	based	base	VERB
admet-553	163	16	on	on	ADP
admet-553	163	17	isocratic	isocratic	PROPN
admet-553	163	18	iam	iam	PROPN
admet-553	163	19	retention	retention	NOUN
admet-553	163	20	factors	factor	NOUN
admet-553	163	21	in	in	ADP
admet-553	163	22	the	the	DET
admet-553	163	23	presence	presence	NOUN
admet-553	163	24	of	of	ADP
admet-553	163	25	30	30	NUM
admet-553	163	26	%	%	NOUN
admet-553	163	27	meoh	meoh	NOUN
admet-553	163	28	and	and	CCONJ
admet-553	163	29	in	in	ADP
admet-553	163	30	silico	silico	NOUN
admet-553	163	31	calculated	calculate	VERB
admet-553	163	32	physicochemical	physicochemical	ADJ
admet-553	163	33	and	and	CCONJ
admet-553	163	34	topological	topological	ADJ
admet-553	163	35	indices	index	NOUN
admet-553	163	36	.	.	PUNCT
admet-553	164	1	the	the	DET
admet-553	164	2	pls	pls	PROPN
admet-553	164	3	model	model	NOUN
admet-553	164	4	constructed	construct	VERB
admet-553	164	5	for	for	ADP
admet-553	164	6	79	79	NUM
admet-553	164	7	structurally	structurally	ADV
admet-553	164	8	unrelated	unrelated	ADJ
admet-553	164	9	analytes	analyte	NOUN
admet-553	164	10	had	have	VERB
admet-553	164	11	however	however	ADV
admet-553	164	12	slightly	slightly	ADV
admet-553	164	13	inferior	inferior	ADJ
admet-553	164	14	statistics	statistic	NOUN
admet-553	164	15	to	to	ADP
admet-553	164	16	that	that	PRON
admet-553	164	17	obtained	obtain	VERB
admet-553	164	18	with	with	ADP
admet-553	164	19	retention	retention	NOUN
admet-553	164	20	factors	factor	NOUN
admet-553	164	21	on	on	ADP
admet-553	164	22	biopartitioning	biopartitione	VERB
admet-553	164	23	micellar	micellar	ADJ
admet-553	164	24	chromatography	chromatography	NOUN
admet-553	164	25	in	in	ADP
admet-553	164	26	the	the	DET
admet-553	164	27	presence	presence	NOUN
admet-553	164	28	of	of	ADP
admet-553	164	29	sodium	sodium	NOUN
admet-553	164	30	dodecyl	dodecyl	PROPN
admet-553	164	31	sulfate	sulfate	PROPN
admet-553	164	32	(	(	PUNCT
admet-553	164	33	sds	sds	PROPN
admet-553	164	34	)	)	PUNCT
admet-553	165	1	[	[	X
admet-553	165	2	10	10	NUM
admet-553	165	3	]	]	PUNCT
admet-553	165	4	.	.	PUNCT
admet-553	166	1	grumetto	grumetto	PROPN
admet-553	166	2	et	et	PROPN
admet-553	166	3	al	al	PROPN
admet-553	166	4	.	.	PUNCT
admet-553	167	1	[	[	X
admet-553	167	2	19	19	NUM
admet-553	167	3	]	]	PUNCT
admet-553	167	4	have	have	AUX
admet-553	167	5	found	find	VERB
admet-553	167	6	a	a	DET
admet-553	167	7	parabolic	parabolic	ADJ
admet-553	167	8	relationship	relationship	NOUN
admet-553	167	9	between	between	ADP
admet-553	167	10	log	log	NOUN
admet-553	167	11	bb	bb	NOUN
admet-553	167	12	and	and	CCONJ
admet-553	167	13	log	log	PROPN
admet-553	167	14	kw(iam	kw(iam	NOUN
admet-553	167	15	)	)	PUNCT
admet-553	167	16	or	or	CCONJ
admet-553	167	17	δlog	δlog	PROPN
admet-553	167	18	kw(iam	kw(iam	PROPN
admet-553	167	19	)	)	PUNCT
admet-553	167	20	,	,	PUNCT
admet-553	167	21	measured	measure	VERB
admet-553	167	22	on	on	ADP
admet-553	167	23	an	an	DET
admet-553	167	24	iamdd2	iamdd2	NOUN
admet-553	167	25	column	column	NOUN
admet-553	167	26	,	,	PUNCT
admet-553	167	27	with	with	ADP
admet-553	167	28	an	an	DET
admet-553	167	29	opposite	opposite	ADJ
admet-553	167	30	sign	sign	NOUN
admet-553	167	31	for	for	ADP
admet-553	167	32	the	the	DET
admet-553	167	33	linear	linear	ADJ
admet-553	167	34	term	term	NOUN
admet-553	167	35	(	(	PUNCT
admet-553	167	36	r2=	r2=	PROPN
admet-553	167	37	0.825	0.825	NUM
admet-553	167	38	and	and	CCONJ
admet-553	167	39	r2=	r2=	PROPN
admet-553	167	40	0.826	0.826	NUM
admet-553	167	41	respectively	respectively	ADV
admet-553	167	42	)	)	PUNCT
admet-553	167	43	.	.	PUNCT
admet-553	168	1	results	result	NOUN
admet-553	168	2	were	be	AUX
admet-553	168	3	inferior	inferior	ADJ
admet-553	168	4	when	when	SCONJ
admet-553	168	5	an	an	DET
admet-553	168	6	iam.mg	iam.mg	PROPN
admet-553	168	7	column	column	NOUN
admet-553	168	8	was	be	AUX
admet-553	168	9	used	use	VERB
admet-553	168	10	.	.	PUNCT
admet-553	169	1	better	well	ADJ
admet-553	169	2	parabolic	parabolic	ADJ
admet-553	169	3	relationships	relationship	NOUN
admet-553	169	4	,	,	PUNCT
admet-553	169	5	however	however	ADV
admet-553	169	6	,	,	PUNCT
admet-553	169	7	were	be	AUX
admet-553	169	8	obtained	obtain	VERB
admet-553	169	9	with	with	ADP
admet-553	169	10	log	log	NOUN
admet-553	169	11	p	p	PROPN
admet-553	169	12	of	of	ADP
admet-553	169	13	the	the	DET
admet-553	169	14	neutral	neutral	ADJ
admet-553	169	15	form	form	NOUN
admet-553	169	16	(	(	PUNCT
admet-553	169	17	r	r	NOUN
admet-553	169	18	2	2	NUM
admet-553	169	19	=	=	SYM
admet-553	169	20	0.880	0.880	NUM
admet-553	169	21	)	)	PUNCT
admet-553	170	1	[	[	X
admet-553	170	2	59	59	NUM
admet-553	170	3	]	]	PUNCT
admet-553	170	4	.	.	PUNCT
admet-553	171	1	the	the	DET
admet-553	171	2	same	same	ADJ
admet-553	171	3	research	research	NOUN
admet-553	171	4	group	group	NOUN
admet-553	171	5	performed	perform	VERB
admet-553	171	6	a	a	DET
admet-553	171	7	comparative	comparative	ADJ
admet-553	171	8	study	study	NOUN
admet-553	171	9	between	between	ADP
admet-553	171	10	iam	iam	PROPN
admet-553	171	11	retention	retention	NOUN
admet-553	171	12	indices	index	NOUN
admet-553	171	13	(	(	PUNCT
admet-553	171	14	log	log	NOUN
admet-553	171	15	kw(iam	kw(iam	NOUN
admet-553	171	16	)	)	PUNCT
admet-553	171	17	and	and	CCONJ
admet-553	171	18	δlog	δlog	PROPN
admet-553	171	19	kw(iam	kw(iam	PROPN
admet-553	171	20	)	)	PUNCT
admet-553	171	21	)	)	PUNCT
admet-553	171	22	and	and	CCONJ
admet-553	171	23	pampa	pampa	NOUN
admet-553	171	24	using	use	VERB
admet-553	171	25	a	a	DET
admet-553	171	26	porcine	porcine	NOUN
admet-553	171	27	brain	brain	NOUN
admet-553	171	28	lipid	lipid	NOUN
admet-553	171	29	extract	extract	NOUN
admet-553	171	30	for	for	ADP
admet-553	171	31	the	the	DET
admet-553	171	32	prediction	prediction	NOUN
admet-553	171	33	of	of	ADP
admet-553	171	34	in	in	ADP
admet-553	171	35	situ	situ	ADJ
admet-553	171	36	bbb	bbb	NOUN
admet-553	171	37	permeability	permeability	NOUN
admet-553	171	38	where	where	SCONJ
admet-553	171	39	they	they	PRON
admet-553	171	40	found	find	VERB
admet-553	171	41	the	the	DET
admet-553	171	42	δlog	δlog	NOUN
admet-553	171	43	kw(iam	kw(iam	NOUN
admet-553	171	44	)	)	PUNCT
admet-553	171	45	parameter	parameter	NOUN
admet-553	171	46	to	to	PART
admet-553	171	47	be	be	AUX
admet-553	171	48	more	more	ADV
admet-553	171	49	efficient	efficient	ADJ
admet-553	171	50	than	than	ADP
admet-553	171	51	pampa	pampa	NOUN
admet-553	171	52	[	[	X
admet-553	171	53	19	19	NUM
admet-553	171	54	]	]	PUNCT
admet-553	171	55	.	.	PUNCT
admet-553	172	1	yoon	yoon	PROPN
admet-553	172	2	et	et	PROPN
admet-553	172	3	al	al	PROPN
admet-553	172	4	.	.	PUNCT
admet-553	173	1	[	[	X
admet-553	173	2	60	60	NUM
admet-553	173	3	]	]	PUNCT
admet-553	173	4	developed	develop	VERB
admet-553	173	5	a	a	DET
admet-553	173	6	classification	classification	NOUN
admet-553	173	7	model	model	NOUN
admet-553	173	8	based	base	VERB
admet-553	173	9	on	on	ADP
admet-553	173	10	iam	iam	PROPN
admet-553	173	11	retention	retention	NOUN
admet-553	173	12	divided	divide	VERB
admet-553	173	13	by	by	ADP
admet-553	173	14	mw	mw	NOUN
admet-553	173	15	to	to	ADP
admet-553	173	16	the	the	DET
admet-553	173	17	n	n	PRON
admet-553	173	18	th	th	X
admet-553	173	19	power	power	NOUN
admet-553	173	20	(	(	PUNCT
admet-553	173	21	kw(iam)/mw	kw(iam)/mw	NOUN
admet-553	173	22	n	n	PROPN
admet-553	173	23	)	)	PUNCT
admet-553	173	24	.	.	PUNCT
admet-553	174	1	the	the	DET
admet-553	174	2	best	good	ADJ
admet-553	174	3	model	model	NOUN
admet-553	174	4	was	be	AUX
admet-553	174	5	obtained	obtain	VERB
admet-553	174	6	using	use	VERB
admet-553	174	7	kw(iam)/mw	kw(iam)/mw	NOUN
admet-553	174	8	4	4	NUM
admet-553	174	9	measured	measure	VERB
admet-553	174	10	at	at	ADP
admet-553	174	11	ph	ph	ADJ
admet-553	174	12	values	value	NOUN
admet-553	174	13	of	of	ADP
admet-553	174	14	5.5	5.5	NUM
admet-553	174	15	and	and	CCONJ
admet-553	174	16	7.0	7.0	NUM
admet-553	174	17	,	,	PUNCT
admet-553	174	18	with	with	ADP
admet-553	174	19	cutoff	cutoff	NOUN
admet-553	174	20	values	value	NOUN
admet-553	174	21	equal	equal	ADJ
admet-553	174	22	to	to	ADP
admet-553	174	23	1.01	1.01	NUM
admet-553	174	24	and	and	CCONJ
admet-553	174	25	0.85	0.85	NUM
admet-553	174	26	,	,	PUNCT
admet-553	174	27	respectively	respectively	ADV
admet-553	174	28	.	.	PUNCT
admet-553	175	1	efforts	effort	NOUN
admet-553	175	2	have	have	AUX
admet-553	175	3	also	also	ADV
admet-553	175	4	been	be	AUX
admet-553	175	5	made	make	VERB
admet-553	175	6	for	for	ADP
admet-553	175	7	the	the	DET
admet-553	175	8	employment	employment	NOUN
admet-553	175	9	of	of	ADP
admet-553	175	10	iam	iam	PROPN
admet-553	175	11	chromatography	chromatography	NOUN
admet-553	175	12	as	as	ADP
admet-553	175	13	a	a	DET
admet-553	175	14	tool	tool	NOUN
admet-553	175	15	to	to	PART
admet-553	175	16	model	model	VERB
admet-553	175	17	the	the	DET
admet-553	175	18	transdermal	transdermal	ADJ
admet-553	175	19	transport	transport	NOUN
admet-553	175	20	of	of	ADP
admet-553	175	21	drugs	drug	NOUN
admet-553	175	22	.	.	PUNCT
admet-553	176	1	in	in	ADP
admet-553	176	2	a	a	DET
admet-553	176	3	comparative	comparative	ADJ
admet-553	176	4	investigation	investigation	NOUN
admet-553	176	5	,	,	PUNCT
admet-553	176	6	lazaro	lazaro	PROPN
admet-553	176	7	et	et	PROPN
admet-553	176	8	al	al	PROPN
admet-553	176	9	.	.	PROPN
admet-553	176	10	explored	explore	VERB
admet-553	176	11	the	the	DET
admet-553	176	12	potential	potential	NOUN
admet-553	176	13	of	of	ADP
admet-553	176	14	iam	iam	PROPN
admet-553	176	15	and	and	CCONJ
admet-553	176	16	c18	c18	NOUN
admet-553	176	17	stationary	stationary	ADJ
admet-553	176	18	phases	phase	NOUN
admet-553	176	19	.	.	PUNCT
admet-553	177	1	they	they	PRON
admet-553	177	2	suggested	suggest	VERB
admet-553	177	3	that	that	SCONJ
admet-553	177	4	iam	iam	PROPN
admet-553	177	5	can	can	AUX
admet-553	177	6	mimic	mimic	VERB
admet-553	177	7	skin	skin	NOUN
admet-553	177	8	partition	partition	NOUN
admet-553	177	9	but	but	CCONJ
admet-553	177	10	that	that	SCONJ
admet-553	177	11	skin	skin	NOUN
admet-553	177	12	permeation	permeation	NOUN
admet-553	177	13	is	be	AUX
admet-553	177	14	closer	close	ADJ
admet-553	177	15	to	to	AUX
admet-553	177	16	elution	elution	NOUN
admet-553	177	17	on	on	ADP
admet-553	177	18	reversed	reverse	VERB
admet-553	177	19	-	-	PUNCT
admet-553	177	20	phase	phase	NOUN
admet-553	177	21	columns	column	NOUN
admet-553	177	22	[	[	X
admet-553	177	23	30	30	NUM
admet-553	177	24	]	]	PUNCT
admet-553	177	25	.	.	PUNCT
admet-553	178	1	barbato	barbato	PROPN
admet-553	178	2	et	et	PROPN
admet-553	178	3	al	al	PROPN
admet-553	178	4	.	.	PROPN
admet-553	178	5	investigated	investigate	VERB
admet-553	178	6	a	a	DET
admet-553	178	7	limited	limited	ADJ
admet-553	178	8	set	set	NOUN
admet-553	178	9	of	of	ADP
admet-553	178	10	12	12	NUM
admet-553	178	11	drugs	drug	NOUN
admet-553	178	12	and	and	CCONJ
admet-553	178	13	used	use	VERB
admet-553	178	14	both	both	CCONJ
admet-553	178	15	the	the	DET
admet-553	178	16	log	log	NOUN
admet-553	178	17	kw(iam	kw(iam	NOUN
admet-553	178	18	)	)	PUNCT
admet-553	178	19	and	and	CCONJ
admet-553	178	20	the	the	DET
admet-553	178	21	δlog	δlog	PROPN
admet-553	178	22	kw(iam	kw(iam	NOUN
admet-553	178	23	)	)	PUNCT
admet-553	178	24	parameters	parameter	NOUN
admet-553	178	25	with	with	ADP
admet-553	178	26	no	no	DET
admet-553	178	27	correlation	correlation	NOUN
admet-553	178	28	of	of	ADP
admet-553	178	29	skin	skin	NOUN
admet-553	178	30	permeability	permeability	NOUN
admet-553	178	31	have	have	AUX
admet-553	178	32	been	be	AUX
admet-553	178	33	observed	observe	VERB
admet-553	178	34	with	with	ADP
admet-553	178	35	log	log	PROPN
admet-553	178	36	kw(iam	kw(iam	NOUN
admet-553	178	37	)	)	PUNCT
admet-553	178	38	,	,	PUNCT
admet-553	178	39	but	but	CCONJ
admet-553	178	40	a	a	DET
admet-553	178	41	negative	negative	ADJ
admet-553	178	42	correlation	correlation	NOUN
admet-553	178	43	with	with	ADP
admet-553	178	44	δlog	δlog	PROPN
admet-553	178	45	kw(iam	kw(iam	PROPN
admet-553	178	46	)	)	PUNCT
admet-553	178	47	was	be	AUX
admet-553	178	48	evident	evident	ADJ
admet-553	178	49	,	,	PUNCT
admet-553	178	50	indicating	indicate	VERB
admet-553	178	51	that	that	SCONJ
admet-553	178	52	polar	polar	ADJ
admet-553	178	53	and	and	CCONJ
admet-553	178	54	electrostatic	electrostatic	ADJ
admet-553	178	55	interactions	interaction	NOUN
admet-553	178	56	hinder	hinder	VERB
admet-553	178	57	molecules	molecule	NOUN
admet-553	178	58	from	from	ADP
admet-553	178	59	crossing	cross	VERB
admet-553	178	60	the	the	DET
admet-553	178	61	skin	skin	NOUN
admet-553	178	62	layer	layer	NOUN
admet-553	178	63	,	,	PUNCT
admet-553	178	64	possibly	possibly	ADV
admet-553	178	65	due	due	ADP
admet-553	178	66	to	to	ADP
admet-553	178	67	repulsive	repulsive	ADJ
admet-553	178	68	forces	force	NOUN
admet-553	178	69	[	[	X
admet-553	178	70	61	61	NUM
admet-553	178	71	]	]	PUNCT
admet-553	178	72	.	.	PUNCT
admet-553	179	1	a	a	DET
admet-553	179	2	point	point	NOUN
admet-553	179	3	of	of	ADP
admet-553	179	4	major	major	ADJ
admet-553	179	5	importance	importance	NOUN
admet-553	179	6	lies	lie	VERB
admet-553	179	7	in	in	ADP
admet-553	179	8	early	early	ADJ
admet-553	179	9	drug	drug	NOUN
admet-553	179	10	safety	safety	NOUN
admet-553	179	11	assessment	assessment	NOUN
admet-553	179	12	.	.	PUNCT
admet-553	180	1	considering	consider	VERB
admet-553	180	2	the	the	DET
admet-553	180	3	binding	bind	VERB
admet-553	180	4	component	component	NOUN
admet-553	180	5	of	of	ADP
admet-553	180	6	the	the	DET
admet-553	180	7	iam	iam	PROPN
admet-553	180	8	retention	retention	NOUN
admet-553	180	9	mechanism	mechanism	NOUN
admet-553	180	10	,	,	PUNCT
admet-553	180	11	a	a	DET
admet-553	180	12	high	high	ADJ
admet-553	180	13	affinity	affinity	NOUN
admet-553	180	14	to	to	PART
admet-553	180	15	iam	iam	VERB
admet-553	180	16	stationary	stationary	ADJ
admet-553	180	17	phases	phase	NOUN
admet-553	180	18	in	in	ADP
admet-553	180	19	the	the	DET
admet-553	180	20	case	case	NOUN
admet-553	180	21	of	of	ADP
admet-553	180	22	basic	basic	ADJ
admet-553	180	23	amphiphilic	amphiphilic	ADJ
admet-553	180	24	drugs	drug	NOUN
admet-553	180	25	may	may	AUX
admet-553	180	26	be	be	AUX
admet-553	180	27	considered	consider	VERB
admet-553	180	28	as	as	ADP
admet-553	180	29	an	an	DET
admet-553	180	30	indication	indication	NOUN
admet-553	180	31	of	of	ADP
admet-553	180	32	drug	drug	NOUN
admet-553	180	33	-	-	PUNCT
admet-553	180	34	induced	induce	VERB
admet-553	180	35	phospholipidosis	phospholipidosis	NOUN
admet-553	180	36	,	,	PUNCT
admet-553	180	37	a	a	DET
admet-553	180	38	situation	situation	NOUN
admet-553	180	39	associated	associate	VERB
admet-553	180	40	with	with	ADP
admet-553	180	41	excessive	excessive	ADJ
admet-553	180	42	accumulation	accumulation	NOUN
admet-553	180	43	of	of	ADP
admet-553	180	44	phospholipids	phospholipid	NOUN
admet-553	180	45	within	within	ADP
admet-553	180	46	lysosomes	lysosome	NOUN
admet-553	180	47	[	[	X
admet-553	180	48	62,63	62,63	NOUN
admet-553	180	49	]	]	PUNCT
admet-553	180	50	.	.	PUNCT
admet-553	181	1	investigations	investigation	NOUN
admet-553	181	2	have	have	AUX
admet-553	181	3	shown	show	VERB
admet-553	181	4	good	good	ADJ
admet-553	181	5	correlation	correlation	NOUN
admet-553	181	6	between	between	ADP
admet-553	181	7	iam	iam	PROPN
admet-553	181	8	-	-	PUNCT
admet-553	181	9	chi	chi	NOUN
admet-553	181	10	indexes	index	NOUN
admet-553	181	11	and	and	CCONJ
admet-553	181	12	phospholipidosis	phospholipidosis	NOUN
admet-553	181	13	risk	risk	NOUN
admet-553	181	14	[	[	X
admet-553	181	15	64	64	NUM
admet-553	181	16	]	]	PUNCT
admet-553	181	17	or	or	CCONJ
admet-553	181	18	phospholipidogenic	phospholipidogenic	ADJ
admet-553	181	19	potential	potential	NOUN
admet-553	181	20	[	[	X
admet-553	181	21	65	65	NUM
admet-553	181	22	]	]	PUNCT
admet-553	181	23	.	.	PUNCT
admet-553	182	1	in	in	ADP
admet-553	182	2	terms	term	NOUN
admet-553	182	3	of	of	ADP
admet-553	182	4	chi(iam	chi(iam	NOUN
admet-553	182	5	)	)	PUNCT
admet-553	182	6	a	a	DET
admet-553	182	7	value	value	NOUN
admet-553	182	8	>	>	X
admet-553	182	9	50	50	NUM
admet-553	182	10	may	may	AUX
admet-553	182	11	be	be	AUX
admet-553	182	12	related	relate	VERB
admet-553	182	13	to	to	ADP
admet-553	182	14	phospholipidosis	phospholipidosis	NOUN
admet-553	182	15	[	[	X
admet-553	182	16	41	41	NUM
admet-553	182	17	]	]	PUNCT
admet-553	182	18	.	.	PUNCT
admet-553	183	1	in	in	ADP
admet-553	183	2	a	a	DET
admet-553	183	3	comparative	comparative	ADJ
admet-553	183	4	study	study	NOUN
admet-553	183	5	of	of	ADP
admet-553	183	6	36	36	NUM
admet-553	183	7	drugs	drug	NOUN
admet-553	183	8	,	,	PUNCT
admet-553	183	9	jiang	jiang	PROPN
admet-553	183	10	and	and	CCONJ
admet-553	183	11	reilly	reilly	ADV
admet-553	183	12	developed	develop	VERB
admet-553	183	13	a	a	DET
admet-553	183	14	simple	simple	ADJ
admet-553	183	15	and	and	CCONJ
admet-553	183	16	rapid	rapid	ADJ
admet-553	183	17	physicochemical	physicochemical	ADJ
admet-553	183	18	screening	screening	NOUN
admet-553	183	19	approach	approach	NOUN
admet-553	183	20	based	base	VERB
admet-553	183	21	on	on	ADP
admet-553	183	22	chromatographic	chromatographic	ADJ
admet-553	183	23	methods	method	NOUN
admet-553	183	24	for	for	ADP
admet-553	183	25	predicting	predict	VERB
admet-553	183	26	the	the	DET
admet-553	183	27	potential	potential	NOUN
admet-553	183	28	of	of	ADP
admet-553	183	29	compounds	compound	NOUN
admet-553	183	30	to	to	PART
admet-553	183	31	induce	induce	VERB
admet-553	183	32	phospholipidosis	phospholipidosis	NOUN
admet-553	183	33	[	[	X
admet-553	183	34	66	66	NUM
admet-553	183	35	]	]	PUNCT
admet-553	183	36	.	.	PUNCT
admet-553	184	1	they	they	PRON
admet-553	184	2	found	find	VERB
admet-553	184	3	an	an	DET
admet-553	184	4	equally	equally	ADV
admet-553	184	5	satisfactory	satisfactory	ADJ
admet-553	184	6	correlation	correlation	NOUN
admet-553	184	7	with	with	ADP
admet-553	184	8	the	the	DET
admet-553	184	9	retention	retention	NOUN
admet-553	184	10	on	on	ADP
admet-553	184	11	electrokinetic	electrokinetic	ADJ
admet-553	184	12	chromatography	chromatography	NOUN
admet-553	184	13	based	base	VERB
admet-553	184	14	on	on	ADP
admet-553	184	15	docusate	docusate	NOUN
admet-553	184	16	sodium	sodium	NOUN
admet-553	184	17	salt	salt	NOUN
admet-553	184	18	(	(	PUNCT
admet-553	184	19	r2=0.87	r2=0.87	NOUN
admet-553	184	20	and	and	CCONJ
admet-553	184	21	r2=0.86	r2=0.86	NOUN
admet-553	184	22	respectively	respectively	ADV
admet-553	184	23	)	)	PUNCT
admet-553	184	24	or	or	CCONJ
admet-553	184	25	with	with	ADP
admet-553	184	26	the	the	DET
admet-553	184	27	logarithm	logarithm	NOUN
admet-553	184	28	of	of	ADP
admet-553	184	29	the	the	DET
admet-553	184	30	volume	volume	NOUN
admet-553	184	31	of	of	ADP
admet-553	184	32	distribution	distribution	NOUN
admet-553	184	33	log	log	NOUN
admet-553	184	34	vd	vd	NOUN
admet-553	184	35	calculated	calculate	VERB
admet-553	184	36	from	from	ADP
admet-553	184	37	iam	iam	PROPN
admet-553	184	38	chromatography	chromatography	NOUN
admet-553	184	39	(	(	PUNCT
admet-553	184	40	chi	chi	NOUN
admet-553	184	41	-	-	PUNCT
admet-553	184	42	iam	iam	PROPN
admet-553	184	43	)	)	PUNCT
admet-553	184	44	and	and	CCONJ
admet-553	184	45	human	human	ADJ
admet-553	184	46	serum	serum	NOUN
admet-553	184	47	albumin	albumin	PROPN
admet-553	184	48	chromatography	chromatography	NOUN
admet-553	184	49	,	,	PUNCT
admet-553	184	50	according	accord	VERB
admet-553	184	51	to	to	ADP
admet-553	184	52	εq	εq	NUM
admet-553	184	53	.	.	PUNCT
admet-553	185	1	(	(	PUNCT
admet-553	185	2	11	11	NUM
admet-553	185	3	)	)	PUNCT
admet-553	185	4	as	as	SCONJ
admet-553	185	5	suggested	suggest	VERB
admet-553	185	6	by	by	ADP
admet-553	185	7	hollosy	hollosy	NOUN
admet-553	185	8	et	et	PROPN
admet-553	185	9	al	al	PROPN
admet-553	186	1	[	[	X
admet-553	186	2	40	40	NUM
admet-553	186	3	]	]	PUNCT
admet-553	186	4	.	.	PUNCT
admet-553	187	1	log	log	VERB
admet-553	187	2	vd	vd	NOUN
admet-553	187	3	=	=	SYM
admet-553	187	4	0.44	0.44	NUM
admet-553	187	5	·	·	PUNCT
admet-553	187	6	log	log	PROPN
admet-553	187	7	k(iam	k(iam	PROPN
admet-553	187	8	)	)	PUNCT
admet-553	187	9	–	–	PUNCT
admet-553	187	10	0.22	0.22	NUM
admet-553	187	11	log	log	NOUN
admet-553	187	12	k(hsa	k(hsa	NOUN
admet-553	187	13	)	)	PUNCT
admet-553	187	14	-0.66	-0.66	NOUN
admet-553	187	15	(	(	PUNCT
admet-553	187	16	11	11	NUM
admet-553	187	17	)	)	PUNCT
admet-553	187	18	(	(	PUNCT
admet-553	187	19	n=	n=	ADJ
admet-553	187	20	179	179	NUM
admet-553	187	21	,	,	PUNCT
admet-553	187	22	r2=	r2=	PROPN
admet-553	187	23	0.76	0.76	NUM
admet-553	187	24	,	,	PUNCT
admet-553	187	25	s=	s=	NOUN
admet-553	187	26	0.33	0.33	NUM
admet-553	187	27	)	)	PUNCT
admet-553	187	28	an	an	DET
admet-553	187	29	analogous	analogous	ADJ
admet-553	187	30	relationship	relationship	NOUN
admet-553	187	31	,	,	PUNCT
admet-553	187	32	resulting	result	VERB
admet-553	187	33	from	from	ADP
admet-553	187	34	a	a	DET
admet-553	187	35	combination	combination	NOUN
admet-553	187	36	of	of	ADP
admet-553	187	37	retention	retention	NOUN
admet-553	187	38	on	on	ADP
admet-553	187	39	both	both	CCONJ
admet-553	187	40	iam	iam	PROPN
admet-553	187	41	and	and	CCONJ
admet-553	187	42	hsa	hsa	PROPN
admet-553	187	43	stationary	stationary	PROPN
admet-553	187	44	admet	admet	PROPN
admet-553	187	45	&	&	CCONJ
admet-553	187	46	dmpk	dmpk	PROPN
admet-553	187	47	6(3	6(3	PROPN
admet-553	187	48	)	)	PUNCT
admet-553	187	49	(	(	PUNCT
admet-553	187	50	2018	2018	NUM
admet-553	187	51	)	)	PUNCT
admet-553	187	52	225	225	NUM
admet-553	187	53	-	-	SYM
admet-553	187	54	241	241	NUM
admet-553	187	55	iam	iam	PROPN
admet-553	187	56	chromatography	chromatography	NOUN
admet-553	187	57	in	in	ADP
admet-553	187	58	medicinal	medicinal	ADJ
admet-553	187	59	chemistry	chemistry	NOUN
admet-553	187	60	and	and	CCONJ
admet-553	187	61	environment	environment	NOUN
admet-553	187	62	doi	doi	PROPN
admet-553	187	63	:	:	PUNCT
admet-553	187	64	10.5599	10.5599	NUM
admet-553	187	65	/	/	SYM
admet-553	187	66	admet.553	admet.553	NOUN
admet-553	187	67	233	233	NUM
admet-553	187	68	phases	phase	NOUN
admet-553	187	69	was	be	AUX
admet-553	187	70	reported	report	VERB
admet-553	187	71	by	by	ADP
admet-553	187	72	valko	valko	PROPN
admet-553	187	73	et	et	PROPN
admet-553	187	74	al	al	PROPN
admet-553	187	75	.	.	PUNCT
admet-553	188	1	[	[	X
admet-553	188	2	67	67	NUM
admet-553	188	3	]	]	PUNCT
admet-553	188	4	to	to	PART
admet-553	188	5	predict	predict	VERB
admet-553	188	6	the	the	DET
admet-553	188	7	unbound	unbound	NOUN
admet-553	188	8	volume	volume	NOUN
admet-553	188	9	of	of	ADP
admet-553	188	10	distribution	distribution	NOUN
admet-553	188	11	(	(	PUNCT
admet-553	188	12	vdu	vdu	PROPN
admet-553	188	13	)	)	PUNCT
admet-553	188	14	,	,	PUNCT
admet-553	188	15	defined	define	VERB
admet-553	188	16	as	as	ADP
admet-553	188	17	the	the	DET
admet-553	188	18	volume	volume	NOUN
admet-553	188	19	of	of	ADP
admet-553	188	20	distribution	distribution	NOUN
admet-553	188	21	divided	divide	VERB
admet-553	188	22	by	by	ADP
admet-553	188	23	the	the	DET
admet-553	188	24	unbound	unbound	NOUN
admet-553	188	25	fraction	fraction	NOUN
admet-553	188	26	(	(	PUNCT
admet-553	188	27	fu	fu	NOUN
admet-553	188	28	)	)	PUNCT
admet-553	188	29	of	of	ADP
admet-553	188	30	the	the	DET
admet-553	188	31	drug	drug	NOUN
admet-553	188	32	in	in	ADP
admet-553	188	33	plasma	plasma	NOUN
admet-553	188	34	:	:	PUNCT
admet-553	188	35	vdu	vdu	PROPN
admet-553	188	36	=	=	SYM
admet-553	188	37	vd	vd	PROPN
admet-553	188	38	/	/	SYM
admet-553	188	39	fu	fu	NOUN
admet-553	188	40	.	.	PUNCT
admet-553	189	1	log	log	VERB
admet-553	189	2	vdu	vdu	PROPN
admet-553	189	3	=	=	PROPN
admet-553	189	4	0.43	0.43	NUM
admet-553	189	5	log	log	NOUN
admet-553	189	6	k(iam	k(iam	PROPN
admet-553	189	7	)	)	PUNCT
admet-553	190	1	+	+	NUM
admet-553	190	2	0.23	0.23	NUM
admet-553	190	3	log	log	NOUN
admet-553	190	4	k(hsa	k(hsa	NOUN
admet-553	190	5	)	)	PUNCT
admet-553	190	6	0.72	0.72	NUM
admet-553	190	7	(	(	PUNCT
admet-553	190	8	12	12	NUM
admet-553	190	9	)	)	PUNCT
admet-553	190	10	(	(	PUNCT
admet-553	190	11	n=70	n=70	PROPN
admet-553	190	12	,	,	PUNCT
admet-553	190	13	r	r	NOUN
admet-553	190	14	2	2	NUM
admet-553	190	15	=	=	SYM
admet-553	190	16	0.84	0.84	NUM
admet-553	190	17	,	,	PUNCT
admet-553	190	18	s=0.32	s=0.32	ADV
admet-553	190	19	)	)	PUNCT
admet-553	190	20	the	the	DET
admet-553	190	21	unbound	unbound	NOUN
admet-553	190	22	volume	volume	NOUN
admet-553	190	23	of	of	ADP
admet-553	190	24	distribution	distribution	NOUN
admet-553	190	25	is	be	AUX
admet-553	190	26	an	an	DET
admet-553	190	27	important	important	ADJ
admet-553	190	28	pharmacokinetic	pharmacokinetic	ADJ
admet-553	190	29	parameter	parameter	NOUN
admet-553	190	30	since	since	SCONJ
admet-553	190	31	it	it	PRON
admet-553	190	32	is	be	AUX
admet-553	190	33	in	in	ADP
admet-553	190	34	principle	principle	NOUN
admet-553	190	35	the	the	DET
admet-553	190	36	reciprocal	reciprocal	ADJ
admet-553	190	37	value	value	NOUN
admet-553	190	38	of	of	ADP
admet-553	190	39	the	the	DET
admet-553	190	40	maximum	maximum	ADJ
admet-553	190	41	drug	drug	NOUN
admet-553	190	42	efficiency	efficiency	NOUN
admet-553	190	43	(	(	PUNCT
admet-553	190	44	demax	demax	NOUN
admet-553	190	45	)	)	PUNCT
admet-553	190	46	defined	define	VERB
admet-553	190	47	by	by	ADP
admet-553	190	48	braggio	braggio	NOUN
admet-553	190	49	et	et	PROPN
admet-553	190	50	al	al	PROPN
admet-553	190	51	.	.	PUNCT
admet-553	191	1	[	[	X
admet-553	191	2	68	68	NUM
admet-553	191	3	]	]	PUNCT
admet-553	191	4	.	.	PUNCT
admet-553	192	1	cell	cell	NOUN
admet-553	192	2	accumulation	accumulation	NOUN
admet-553	192	3	and	and	CCONJ
admet-553	192	4	retention	retention	NOUN
admet-553	192	5	may	may	AUX
admet-553	192	6	be	be	AUX
admet-553	192	7	very	very	ADV
admet-553	192	8	important	important	ADJ
admet-553	192	9	for	for	ADP
admet-553	192	10	drug	drug	NOUN
admet-553	192	11	action	action	NOUN
admet-553	192	12	in	in	ADP
admet-553	192	13	particular	particular	ADJ
admet-553	192	14	for	for	ADP
admet-553	192	15	drugs	drug	NOUN
admet-553	192	16	which	which	PRON
admet-553	192	17	are	be	AUX
admet-553	192	18	intended	intend	VERB
admet-553	192	19	to	to	PART
admet-553	192	20	penetrate	penetrate	VERB
admet-553	192	21	to	to	ADP
admet-553	192	22	intracellular	intracellular	ADJ
admet-553	192	23	targets	target	NOUN
admet-553	192	24	or	or	CCONJ
admet-553	192	25	intracellular	intracellular	ADJ
admet-553	192	26	pathogens	pathogen	NOUN
admet-553	192	27	,	,	PUNCT
admet-553	192	28	as	as	ADV
admet-553	192	29	well	well	ADV
admet-553	192	30	as	as	ADP
admet-553	192	31	to	to	PART
admet-553	192	32	maintain	maintain	VERB
admet-553	192	33	a	a	DET
admet-553	192	34	prolonged	prolonged	ADJ
admet-553	192	35	presence	presence	NOUN
admet-553	192	36	in	in	ADP
admet-553	192	37	the	the	DET
admet-553	192	38	inflammatory	inflammatory	ADJ
admet-553	192	39	cells	cell	NOUN
admet-553	192	40	[	[	X
admet-553	192	41	69	69	NUM
admet-553	192	42	]	]	PUNCT
admet-553	192	43	.	.	PUNCT
admet-553	193	1	encouraging	encourage	VERB
admet-553	193	2	results	result	NOUN
admet-553	193	3	have	have	AUX
admet-553	193	4	been	be	AUX
admet-553	193	5	reported	report	VERB
admet-553	193	6	by	by	ADP
admet-553	193	7	gordon	gordon	PROPN
admet-553	193	8	et	et	PROPN
admet-553	193	9	al	al	PROPN
admet-553	193	10	.	.	PUNCT
admet-553	194	1	[	[	X
admet-553	194	2	70	70	X
admet-553	194	3	]	]	PUNCT
admet-553	194	4	when	when	SCONJ
admet-553	194	5	plotting	plot	VERB
admet-553	194	6	the	the	DET
admet-553	194	7	log	log	NOUN
admet-553	194	8	cell	cell	NOUN
admet-553	194	9	concentration	concentration	NOUN
admet-553	194	10	,	,	PUNCT
admet-553	194	11	determined	determine	VERB
admet-553	194	12	by	by	ADP
admet-553	194	13	the	the	DET
admet-553	194	14	high	high	ADJ
admet-553	194	15	-	-	PUNCT
admet-553	194	16	throughput	throughput	NOUN
admet-553	194	17	screening	screen	VERB
admet-553	194	18	assay	assay	NOUN
admet-553	194	19	rapidfire	rapidfire	NOUN
admet-553	194	20	,	,	PUNCT
admet-553	194	21	versus	versus	X
admet-553	194	22	log	log	PROPN
admet-553	194	23	k(iam	k(iam	PROPN
admet-553	194	24	)	)	PUNCT
admet-553	194	25	a	a	DET
admet-553	194	26	positive	positive	ADJ
admet-553	194	27	trend	trend	NOUN
admet-553	194	28	was	be	AUX
admet-553	194	29	observed	observe	VERB
admet-553	194	30	with	with	ADP
admet-553	194	31	a	a	DET
admet-553	194	32	correlation	correlation	NOUN
admet-553	194	33	coefficient	coefficient	NOUN
admet-553	194	34	r=0.69	r=0.69	NOUN
admet-553	194	35	,	,	PUNCT
admet-553	194	36	while	while	SCONJ
admet-553	194	37	the	the	DET
admet-553	194	38	corresponding	corresponding	ADJ
admet-553	194	39	correlation	correlation	NOUN
admet-553	194	40	with	with	ADP
admet-553	194	41	clogp	clogp	NOUN
admet-553	194	42	showed	show	VERB
admet-553	194	43	a	a	DET
admet-553	194	44	correlation	correlation	NOUN
admet-553	194	45	coefficient	coefficient	NOUN
admet-553	194	46	r=0.42	r=0.42	NOUN
admet-553	194	47	.	.	PUNCT
admet-553	195	1	the	the	DET
admet-553	195	2	use	use	NOUN
admet-553	195	3	of	of	ADP
admet-553	195	4	iam	iam	PROPN
admet-553	195	5	chromatography	chromatography	NOUN
admet-553	195	6	for	for	ADP
admet-553	195	7	the	the	DET
admet-553	195	8	prediction	prediction	NOUN
admet-553	195	9	of	of	ADP
admet-553	195	10	ecotoxicity	ecotoxicity	NOUN
admet-553	195	11	the	the	DET
admet-553	195	12	environment	environment	NOUN
admet-553	195	13	is	be	AUX
admet-553	195	14	continuously	continuously	ADV
admet-553	195	15	exposed	expose	VERB
admet-553	195	16	to	to	ADP
admet-553	195	17	a	a	DET
admet-553	195	18	great	great	ADJ
admet-553	195	19	variety	variety	NOUN
admet-553	195	20	of	of	ADP
admet-553	195	21	chemical	chemical	ADJ
admet-553	195	22	substances	substance	NOUN
admet-553	195	23	coming	come	VERB
admet-553	195	24	from	from	ADP
admet-553	195	25	industrial	industrial	ADJ
admet-553	195	26	,	,	PUNCT
admet-553	195	27	agricultural	agricultural	ADJ
admet-553	195	28	,	,	PUNCT
admet-553	195	29	municipal	municipal	ADJ
admet-553	195	30	and	and	CCONJ
admet-553	195	31	natural	natural	ADJ
admet-553	195	32	physicochemical	physicochemical	ADJ
admet-553	195	33	and	and	CCONJ
admet-553	195	34	biological	biological	ADJ
admet-553	195	35	processes	process	NOUN
admet-553	195	36	.	.	PUNCT
admet-553	196	1	new	new	ADJ
admet-553	196	2	compounds	compound	NOUN
admet-553	196	3	are	be	AUX
admet-553	196	4	synthesized	synthesize	VERB
admet-553	196	5	and	and	CCONJ
admet-553	196	6	tested	test	VERB
admet-553	196	7	as	as	ADP
admet-553	196	8	drugs	drug	NOUN
admet-553	196	9	,	,	PUNCT
admet-553	196	10	ingredients	ingredient	NOUN
admet-553	196	11	of	of	ADP
admet-553	196	12	cosmetics	cosmetic	NOUN
admet-553	196	13	,	,	PUNCT
admet-553	196	14	food	food	NOUN
admet-553	196	15	additives	additive	NOUN
admet-553	196	16	,	,	PUNCT
admet-553	196	17	pesticides	pesticide	NOUN
admet-553	196	18	,	,	PUNCT
admet-553	196	19	plasticizers	plasticizer	NOUN
admet-553	196	20	or	or	CCONJ
admet-553	196	21	for	for	ADP
admet-553	196	22	general	general	ADJ
admet-553	196	23	use	use	NOUN
admet-553	196	24	in	in	ADP
admet-553	196	25	technical	technical	ADJ
admet-553	196	26	and	and	CCONJ
admet-553	196	27	industrial	industrial	ADJ
admet-553	196	28	purposes	purpose	NOUN
admet-553	196	29	,	,	PUNCT
admet-553	196	30	while	while	SCONJ
admet-553	196	31	others	other	NOUN
admet-553	196	32	can	can	AUX
admet-553	196	33	be	be	AUX
admet-553	196	34	produced	produce	VERB
admet-553	196	35	as	as	ADP
admet-553	196	36	a	a	DET
admet-553	196	37	result	result	NOUN
admet-553	196	38	of	of	ADP
admet-553	196	39	natural	natural	ADJ
admet-553	196	40	biological	biological	ADJ
admet-553	196	41	processes	process	NOUN
admet-553	196	42	[	[	X
admet-553	196	43	71	71	NUM
admet-553	196	44	]	]	PUNCT
admet-553	196	45	.	.	PUNCT
admet-553	197	1	responsible	responsible	ADJ
admet-553	197	2	product	product	NOUN
admet-553	197	3	design	design	NOUN
admet-553	197	4	should	should	AUX
admet-553	197	5	take	take	VERB
admet-553	197	6	into	into	ADP
admet-553	197	7	consideration	consideration	NOUN
admet-553	197	8	the	the	DET
admet-553	197	9	possible	possible	ADJ
admet-553	197	10	risks	risk	NOUN
admet-553	197	11	in	in	ADP
admet-553	197	12	human	human	ADJ
admet-553	197	13	health	health	NOUN
admet-553	197	14	and	and	CCONJ
admet-553	197	15	to	to	ADP
admet-553	197	16	ecosystems	ecosystem	NOUN
admet-553	197	17	.	.	PUNCT
admet-553	198	1	the	the	DET
admet-553	198	2	evaluation	evaluation	NOUN
admet-553	198	3	of	of	ADP
admet-553	198	4	ecotoxicity	ecotoxicity	NOUN
admet-553	198	5	indices	index	NOUN
admet-553	198	6	is	be	AUX
admet-553	198	7	involved	involve	VERB
admet-553	198	8	in	in	ADP
admet-553	198	9	the	the	DET
admet-553	198	10	reach	reach	NOUN
admet-553	198	11	regulation	regulation	NOUN
admet-553	198	12	“	"	PUNCT
admet-553	198	13	no	no	DET
admet-553	198	14	data	data	NOUN
admet-553	198	15	no	no	DET
admet-553	198	16	market	market	NOUN
admet-553	198	17	”	"	PUNCT
admet-553	199	1	[	[	X
admet-553	199	2	72	72	NUM
admet-553	199	3	]	]	PUNCT
admet-553	199	4	.	.	PUNCT
admet-553	200	1	among	among	ADP
admet-553	200	2	other	other	ADJ
admet-553	200	3	eco	eco	NOUN
admet-553	200	4	-	-	PUNCT
admet-553	200	5	toxicological	toxicological	ADJ
admet-553	200	6	endpoints	endpoint	NOUN
admet-553	200	7	,	,	PUNCT
admet-553	200	8	median	median	ADJ
admet-553	200	9	toxicity	toxicity	NOUN
admet-553	200	10	,	,	PUNCT
admet-553	200	11	i.e.	i.e.	X
admet-553	200	12	lethal	lethal	ADJ
admet-553	200	13	concentration	concentration	NOUN
admet-553	200	14	lc50	lc50	PROPN
admet-553	200	15	in	in	ADP
admet-553	200	16	aquatic	aquatic	ADJ
admet-553	200	17	organisms	organism	NOUN
admet-553	200	18	and	and	CCONJ
admet-553	200	19	lethal	lethal	ADJ
admet-553	200	20	dose	dose	NOUN
admet-553	200	21	,	,	PUNCT
admet-553	200	22	ld50	ld50	PROPN
admet-553	200	23	,	,	PUNCT
admet-553	200	24	for	for	ADP
admet-553	200	25	terrestrial	terrestrial	ADJ
admet-553	200	26	organisms	organism	NOUN
admet-553	200	27	as	as	ADV
admet-553	200	28	well	well	ADV
admet-553	200	29	as	as	ADP
admet-553	200	30	bioaccumulation	bioaccumulation	NOUN
admet-553	200	31	are	be	AUX
admet-553	200	32	of	of	ADP
admet-553	200	33	major	major	ADJ
admet-553	200	34	importance	importance	NOUN
admet-553	200	35	.	.	PUNCT
admet-553	201	1	experimental	experimental	ADJ
admet-553	201	2	measurements	measurement	NOUN
admet-553	201	3	on	on	ADP
admet-553	201	4	biological	biological	ADJ
admet-553	201	5	organisms	organism	NOUN
admet-553	201	6	for	for	ADP
admet-553	201	7	the	the	DET
admet-553	201	8	thousands	thousand	NOUN
admet-553	201	9	of	of	ADP
admet-553	201	10	compounds	compound	NOUN
admet-553	201	11	for	for	ADP
admet-553	201	12	various	various	ADJ
admet-553	201	13	uses	use	NOUN
admet-553	201	14	are	be	AUX
admet-553	201	15	simply	simply	ADV
admet-553	201	16	not	not	PART
admet-553	201	17	possible	possible	ADJ
admet-553	201	18	.	.	PUNCT
admet-553	202	1	in	in	ADP
admet-553	202	2	silico	silico	NOUN
admet-553	202	3	systems	system	NOUN
admet-553	202	4	can	can	AUX
admet-553	202	5	be	be	AUX
admet-553	202	6	employed	employ	VERB
admet-553	202	7	for	for	ADP
admet-553	202	8	ecotoxicological	ecotoxicological	ADJ
admet-553	202	9	investigations	investigation	NOUN
admet-553	202	10	,	,	PUNCT
admet-553	202	11	in	in	ADP
admet-553	202	12	which	which	PRON
admet-553	202	13	the	the	DET
admet-553	202	14	logarithm	logarithm	NOUN
admet-553	202	15	of	of	ADP
admet-553	202	16	the	the	DET
admet-553	202	17	octanol	octanol	NOUN
admet-553	202	18	-	-	PUNCT
admet-553	202	19	water	water	NOUN
admet-553	202	20	partition	partition	NOUN
admet-553	202	21	coefficient	coefficient	NOUN
admet-553	202	22	,	,	PUNCT
admet-553	202	23	symbolized	symbolize	VERB
admet-553	202	24	in	in	ADP
admet-553	202	25	such	such	ADJ
admet-553	202	26	studies	study	NOUN
admet-553	202	27	as	as	ADP
admet-553	202	28	log	log	PROPN
admet-553	202	29	kow	kow	PROPN
admet-553	202	30	,	,	PUNCT
admet-553	202	31	is	be	AUX
admet-553	202	32	a	a	DET
admet-553	202	33	principal	principal	ADJ
admet-553	202	34	parameter	parameter	NOUN
admet-553	203	1	[	[	X
admet-553	203	2	73	73	NUM
admet-553	203	3	]	]	PUNCT
admet-553	203	4	.	.	PUNCT
admet-553	204	1	several	several	ADJ
admet-553	204	2	authors	author	NOUN
admet-553	204	3	have	have	AUX
admet-553	204	4	proposed	propose	VERB
admet-553	204	5	linear	linear	ADJ
admet-553	204	6	solvation	solvation	NOUN
admet-553	204	7	energy	energy	NOUN
admet-553	204	8	relationships	relationship	NOUN
admet-553	204	9	(	(	PUNCT
admet-553	204	10	lser	lser	NOUN
admet-553	204	11	)	)	PUNCT
admet-553	204	12	for	for	ADP
admet-553	204	13	ecological	ecological	ADJ
admet-553	204	14	risk	risk	NOUN
admet-553	204	15	assessment	assessment	NOUN
admet-553	205	1	[	[	X
admet-553	205	2	71,74	71,74	NUM
admet-553	205	3	-	-	PUNCT
admet-553	205	4	81	81	NUM
admet-553	205	5	]	]	PUNCT
admet-553	205	6	.	.	PUNCT
admet-553	206	1	however	however	ADV
admet-553	206	2	,	,	PUNCT
admet-553	206	3	failure	failure	NOUN
admet-553	206	4	in	in	ADP
admet-553	206	5	the	the	DET
admet-553	206	6	selection	selection	NOUN
admet-553	206	7	of	of	ADP
admet-553	206	8	the	the	DET
admet-553	206	9	appropriate	appropriate	ADJ
admet-553	206	10	model	model	NOUN
admet-553	206	11	can	can	AUX
admet-553	206	12	result	result	VERB
admet-553	206	13	in	in	ADP
admet-553	206	14	a	a	DET
admet-553	206	15	1000	1000	NUM
admet-553	206	16	-	-	PUNCT
admet-553	206	17	fold	fold	ADJ
admet-553	206	18	error	error	NOUN
admet-553	206	19	in	in	ADP
admet-553	206	20	the	the	DET
admet-553	206	21	estimated	estimate	VERB
admet-553	206	22	indices	index	NOUN
admet-553	206	23	[	[	X
admet-553	206	24	82	82	NUM
admet-553	206	25	]	]	PUNCT
admet-553	206	26	.	.	PUNCT
admet-553	207	1	a	a	DET
admet-553	207	2	popular	popular	ADJ
admet-553	207	3	predictive	predictive	ADJ
admet-553	207	4	tool	tool	NOUN
admet-553	207	5	for	for	ADP
admet-553	207	6	environmental	environmental	ADJ
admet-553	207	7	investigations	investigation	NOUN
admet-553	207	8	is	be	AUX
admet-553	207	9	the	the	DET
admet-553	207	10	estimation	estimation	NOUN
admet-553	207	11	program	program	NOUN
admet-553	207	12	interface	interface	NOUN
admet-553	207	13	(	(	PUNCT
admet-553	207	14	epi	epi	NOUN
admet-553	207	15	suite	suite	NOUN
admet-553	207	16	)	)	PUNCT
admet-553	207	17	software	software	NOUN
admet-553	207	18	,	,	PUNCT
admet-553	207	19	freely	freely	ADV
admet-553	207	20	available	available	ADJ
admet-553	207	21	from	from	ADP
admet-553	207	22	the	the	DET
admet-553	207	23	environmental	environmental	PROPN
admet-553	207	24	protection	protection	PROPN
admet-553	207	25	agency	agency	PROPN
admet-553	207	26	(	(	PUNCT
admet-553	207	27	epa	epa	PROPN
admet-553	207	28	)	)	PUNCT
admet-553	208	1	[	[	X
admet-553	208	2	83	83	NUM
admet-553	208	3	]	]	PUNCT
admet-553	208	4	.	.	PUNCT
admet-553	209	1	module	module	NOUN
admet-553	209	2	bcfbaf	bcfbaf	PROPN
admet-553	209	3	,	,	PUNCT
admet-553	209	4	based	base	VERB
admet-553	209	5	on	on	ADP
admet-553	209	6	the	the	DET
admet-553	209	7	work	work	NOUN
admet-553	209	8	of	of	ADP
admet-553	209	9	meylan	meylan	PROPN
admet-553	209	10	et	et	PROPN
admet-553	209	11	al	al	PROPN
admet-553	209	12	.	.	PUNCT
admet-553	210	1	[	[	X
admet-553	210	2	84	84	NUM
admet-553	210	3	]	]	PUNCT
admet-553	210	4	,	,	PUNCT
admet-553	210	5	calculates	calculate	VERB
admet-553	210	6	fish	fish	VERB
admet-553	210	7	the	the	DET
admet-553	210	8	bioconcentration	bioconcentration	NOUN
admet-553	210	9	factor	factor	NOUN
admet-553	210	10	and	and	CCONJ
admet-553	210	11	ecosar	ecosar	PROPN
admet-553	210	12	module	module	NOUN
admet-553	210	13	,	,	PUNCT
admet-553	210	14	based	base	VERB
admet-553	210	15	on	on	ADP
admet-553	210	16	the	the	DET
admet-553	210	17	work	work	NOUN
admet-553	210	18	of	of	ADP
admet-553	210	19	russon	russon	NOUN
admet-553	210	20	et	et	PROPN
admet-553	210	21	al	al	PROPN
admet-553	210	22	.	.	PUNCT
admet-553	211	1	[	[	X
admet-553	211	2	82	82	NUM
admet-553	211	3	]	]	PUNCT
admet-553	211	4	,	,	PUNCT
admet-553	211	5	and	and	CCONJ
admet-553	211	6	estimates	estimate	VERB
admet-553	211	7	the	the	DET
admet-553	211	8	aquatic	aquatic	ADJ
admet-553	211	9	toxicity	toxicity	NOUN
admet-553	211	10	of	of	ADP
admet-553	211	11	compounds	compound	NOUN
admet-553	211	12	.	.	PUNCT
admet-553	212	1	chromatographic	chromatographic	ADJ
admet-553	212	2	techniques	technique	NOUN
admet-553	212	3	offer	offer	VERB
admet-553	212	4	an	an	DET
admet-553	212	5	experimental	experimental	ADJ
admet-553	212	6	alternative	alternative	NOUN
admet-553	212	7	for	for	ADP
admet-553	212	8	the	the	DET
admet-553	212	9	rapid	rapid	ADJ
admet-553	212	10	evaluation	evaluation	NOUN
admet-553	212	11	of	of	ADP
admet-553	212	12	ecotoxicological	ecotoxicological	ADJ
admet-553	212	13	endpoints	endpoint	NOUN
admet-553	212	14	.	.	PUNCT
admet-553	213	1	bio	bio	ADJ
admet-553	213	2	-	-	ADJ
admet-553	213	3	partitioning	partitioning	ADJ
admet-553	213	4	liquid	liquid	ADJ
admet-553	213	5	chromatography	chromatography	NOUN
admet-553	213	6	(	(	PUNCT
admet-553	213	7	blc	blc	NOUN
admet-553	213	8	)	)	PUNCT
admet-553	213	9	,	,	PUNCT
admet-553	213	10	as	as	SCONJ
admet-553	213	11	named	name	VERB
admet-553	213	12	by	by	ADP
admet-553	213	13	the	the	DET
admet-553	213	14	escuder	escuder	NOUN
admet-553	213	15	-	-	PUNCT
admet-553	213	16	gilabert	gilabert	NOUN
admet-553	213	17	group	group	NOUN
admet-553	213	18	[	[	X
admet-553	213	19	85	85	NUM
admet-553	213	20	]	]	PUNCT
admet-553	213	21	was	be	AUX
admet-553	213	22	the	the	DET
admet-553	213	23	first	first	ADJ
admet-553	213	24	biomimetic	biomimetic	ADJ
admet-553	213	25	liquid	liquid	ADJ
admet-553	213	26	chromatographic	chromatographic	ADJ
admet-553	213	27	approach	approach	NOUN
admet-553	213	28	implemented	implement	VERB
admet-553	213	29	for	for	ADP
admet-553	213	30	ecotoxicological	ecotoxicological	ADJ
admet-553	213	31	purposes	purpose	NOUN
admet-553	213	32	.	.	PUNCT
admet-553	214	1	blc	blc	PROPN
admet-553	214	2	uses	use	VERB
admet-553	214	3	micellar	micellar	ADJ
admet-553	214	4	mobile	mobile	ADJ
admet-553	214	5	phases	phase	NOUN
admet-553	214	6	formed	form	VERB
admet-553	214	7	mainly	mainly	ADV
admet-553	214	8	by	by	ADP
admet-553	214	9	the	the	DET
admet-553	214	10	addition	addition	NOUN
admet-553	214	11	of	of	ADP
admet-553	214	12	the	the	DET
admet-553	214	13	non	non	ADJ
admet-553	214	14	-	-	ADJ
admet-553	214	15	ionic	ionic	ADJ
admet-553	214	16	surfactant	surfactant	ADJ
admet-553	214	17	polyoxyethylene(23)lauryl	polyoxyethylene(23)lauryl	NOUN
admet-553	214	18	ether	ether	NOUN
admet-553	214	19	(	(	PUNCT
admet-553	214	20	brij35	brij35	PROPN
admet-553	214	21	)	)	PUNCT
admet-553	214	22	.	.	PUNCT
admet-553	215	1	it	it	PRON
admet-553	215	2	has	have	AUX
admet-553	215	3	been	be	AUX
admet-553	215	4	employed	employ	VERB
admet-553	215	5	for	for	ADP
admet-553	215	6	the	the	DET
admet-553	215	7	predictions	prediction	NOUN
admet-553	215	8	of	of	ADP
admet-553	215	9	bioconcentration	bioconcentration	NOUN
admet-553	215	10	factors	factor	NOUN
admet-553	215	11	[	[	X
admet-553	215	12	86,87	86,87	X
admet-553	215	13	]	]	PUNCT
admet-553	215	14	,	,	PUNCT
admet-553	215	15	skin	skin	NOUN
admet-553	215	16	permeability	permeability	NOUN
admet-553	215	17	[	[	X
admet-553	215	18	87	87	NUM
admet-553	215	19	]	]	PUNCT
admet-553	215	20	and	and	CCONJ
admet-553	215	21	toxicity	toxicity	NOUN
admet-553	215	22	(	(	PUNCT
admet-553	215	23	plc50	plc50	VERB
admet-553	215	24	in	in	ADP
admet-553	215	25	fathead	fathead	NOUN
admet-553	215	26	minnow	minnow	PROPN
admet-553	215	27	)	)	PUNCT
admet-553	216	1	[	[	X
admet-553	216	2	88	88	NUM
admet-553	216	3	]	]	PUNCT
admet-553	216	4	of	of	ADP
admet-553	216	5	xenobiotics	xenobiotics	PROPN
admet-553	216	6	.	.	PUNCT
admet-553	217	1	in	in	ADP
admet-553	217	2	recent	recent	ADJ
admet-553	217	3	years	year	NOUN
admet-553	217	4	,	,	PUNCT
admet-553	217	5	iam	iam	PROPN
admet-553	217	6	technology	technology	NOUN
admet-553	217	7	has	have	AUX
admet-553	217	8	unfolded	unfold	VERB
admet-553	217	9	new	new	ADJ
admet-553	217	10	perspectives	perspective	NOUN
admet-553	217	11	in	in	ADP
admet-553	217	12	the	the	DET
admet-553	217	13	field	field	NOUN
admet-553	217	14	of	of	ADP
admet-553	217	15	ecotoxicology	ecotoxicology	NOUN
admet-553	217	16	.	.	PUNCT
admet-553	218	1	as	as	SCONJ
admet-553	218	2	iam	iam	PROPN
admet-553	218	3	retention	retention	NOUN
admet-553	218	4	factors	factor	NOUN
admet-553	218	5	reflect	reflect	VERB
admet-553	218	6	permeability	permeability	NOUN
admet-553	218	7	of	of	ADP
admet-553	218	8	xenobiotics	xenobiotics	PROPN
admet-553	218	9	through	through	ADP
admet-553	218	10	cell	cell	NOUN
admet-553	218	11	membranes	membrane	NOUN
admet-553	218	12	governed	govern	VERB
admet-553	218	13	by	by	ADP
admet-553	218	14	passive	passive	ADJ
admet-553	218	15	diffusion	diffusion	NOUN
admet-553	218	16	as	as	ADV
admet-553	218	17	well	well	ADV
admet-553	218	18	as	as	ADP
admet-553	218	19	membrane	membrane	NOUN
admet-553	218	20	accumulation	accumulation	NOUN
admet-553	218	21	,	,	PUNCT
admet-553	218	22	it	it	PRON
admet-553	218	23	is	be	AUX
admet-553	218	24	plausible	plausible	ADJ
admet-553	218	25	that	that	SCONJ
admet-553	218	26	it	it	PRON
admet-553	218	27	can	can	AUX
admet-553	218	28	be	be	AUX
admet-553	218	29	used	use	VERB
admet-553	218	30	to	to	PART
admet-553	218	31	provide	provide	VERB
admet-553	218	32	ecotoxicological	ecotoxicological	ADJ
admet-553	218	33	indices	index	NOUN
admet-553	218	34	to	to	ADP
admet-553	218	35	f.	f.	PROPN
admet-553	218	36	tsopelas	tsopelas	PROPN
admet-553	218	37	,	,	PUNCT
admet-553	218	38	c.	c.	PROPN
admet-553	218	39	stergiopoulos	stergiopoulos	PROPN
admet-553	218	40	,	,	PUNCT
admet-553	218	41	a.	a.	NOUN
admet-553	218	42	tsantili	tsantili	NOUN
admet-553	218	43	-	-	PUNCT
admet-553	218	44	kakoulidou	kakoulidou	NOUN
admet-553	218	45	admet	admet	PROPN
admet-553	218	46	&	&	CCONJ
admet-553	218	47	dmpk	dmpk	PROPN
admet-553	218	48	6(3	6(3	PROPN
admet-553	218	49	)	)	PUNCT
admet-553	218	50	(	(	PUNCT
admet-553	218	51	2018	2018	NUM
admet-553	218	52	)	)	PUNCT
admet-553	218	53	225	225	NUM
admet-553	218	54	-	-	SYM
admet-553	218	55	241	241	NUM
admet-553	218	56	234	234	NUM
admet-553	218	57	express	express	ADJ
admet-553	218	58	median	median	ADJ
admet-553	218	59	toxicity	toxicity	NOUN
admet-553	218	60	and	and	CCONJ
admet-553	218	61	bioconcentration	bioconcentration	NOUN
admet-553	218	62	or	or	CCONJ
admet-553	218	63	to	to	PART
admet-553	218	64	construct	construct	VERB
admet-553	218	65	a	a	DET
admet-553	218	66	lipophilicity	lipophilicity	NOUN
admet-553	218	67	scale	scale	NOUN
admet-553	218	68	.	.	PUNCT
admet-553	219	1	stepnowski	stepnowski	PROPN
admet-553	219	2	and	and	CCONJ
admet-553	219	3	storoniak	storoniak	NOUN
admet-553	219	4	[	[	X
admet-553	219	5	89	89	NUM
admet-553	219	6	]	]	PUNCT
admet-553	219	7	compared	compare	VERB
admet-553	219	8	iam	iam	PROPN
admet-553	219	9	and	and	CCONJ
admet-553	219	10	reversed	reverse	VERB
admet-553	219	11	phase	phase	NOUN
admet-553	219	12	retention	retention	NOUN
admet-553	219	13	as	as	ADV
admet-553	219	14	well	well	ADV
admet-553	219	15	as	as	ADP
admet-553	219	16	octanol	octanol	NOUN
admet-553	219	17	-	-	PUNCT
admet-553	219	18	water	water	NOUN
admet-553	219	19	partitioning	partitioning	NOUN
admet-553	219	20	as	as	ADP
admet-553	219	21	lipophilicity	lipophilicity	NOUN
admet-553	219	22	indices	index	NOUN
admet-553	219	23	of	of	ADP
admet-553	219	24	hydrophilic	hydrophilic	ADJ
admet-553	219	25	imidazolium	imidazolium	NOUN
admet-553	219	26	ionic	ionic	ADJ
admet-553	219	27	liquids	liquid	NOUN
admet-553	219	28	.	.	PUNCT
admet-553	220	1	the	the	DET
admet-553	220	2	extrapolated	extrapolate	VERB
admet-553	220	3	log	log	NOUN
admet-553	220	4	kw(iam	kw(iam	NOUN
admet-553	220	5	)	)	PUNCT
admet-553	220	6	values	value	NOUN
admet-553	220	7	were	be	AUX
admet-553	220	8	higher	high	ADJ
admet-553	220	9	than	than	ADP
admet-553	220	10	the	the	DET
admet-553	220	11	corresponding	corresponding	ADJ
admet-553	220	12	logkw	logkw	NOUN
admet-553	220	13	on	on	ADP
admet-553	220	14	reversedphase	reversedphase	NOUN
admet-553	220	15	stationary	stationary	ADJ
admet-553	220	16	phases	phase	NOUN
admet-553	220	17	and	and	CCONJ
admet-553	220	18	log	log	VERB
admet-553	220	19	p	p	PRON
admet-553	220	20	,	,	PUNCT
admet-553	220	21	due	due	ADP
admet-553	220	22	to	to	ADP
admet-553	220	23	the	the	DET
admet-553	220	24	development	development	NOUN
admet-553	220	25	of	of	ADP
admet-553	220	26	electrostatic	electrostatic	ADJ
admet-553	220	27	interactions	interaction	NOUN
admet-553	220	28	of	of	ADP
admet-553	220	29	the	the	DET
admet-553	220	30	positively	positively	ADV
admet-553	220	31	charged	charge	VERB
admet-553	220	32	nitrogen	nitrogen	NOUN
admet-553	220	33	of	of	ADP
admet-553	220	34	the	the	DET
admet-553	220	35	solutes	solute	NOUN
admet-553	220	36	with	with	ADP
admet-553	220	37	the	the	DET
admet-553	220	38	phosphate	phosphate	ADJ
admet-553	220	39	anions	anion	NOUN
admet-553	220	40	of	of	ADP
admet-553	220	41	the	the	DET
admet-553	220	42	iam	iam	PROPN
admet-553	220	43	surface	surface	NOUN
admet-553	220	44	[	[	X
admet-553	220	45	89	89	NUM
admet-553	220	46	]	]	PUNCT
admet-553	220	47	.	.	PUNCT
admet-553	221	1	an	an	DET
admet-553	221	2	analogous	analogous	ADJ
admet-553	221	3	investigation	investigation	NOUN
admet-553	221	4	was	be	AUX
admet-553	221	5	performed	perform	VERB
admet-553	221	6	by	by	ADP
admet-553	221	7	janicka	janicka	PROPN
admet-553	222	1	[	[	X
admet-553	222	2	90	90	NUM
admet-553	222	3	]	]	PUNCT
admet-553	222	4	,	,	PUNCT
admet-553	222	5	who	who	PRON
admet-553	222	6	compared	compare	VERB
admet-553	222	7	iam	iam	PROPN
admet-553	222	8	with	with	ADP
admet-553	222	9	reversedphase	reversedphase	NOUN
admet-553	222	10	,	,	PUNCT
admet-553	222	11	cholesterol	cholesterol	NOUN
admet-553	222	12	phase	phase	NOUN
admet-553	222	13	and	and	CCONJ
admet-553	222	14	micellar	micellar	NOUN
admet-553	222	15	chromatography	chromatography	NOUN
admet-553	222	16	.	.	PUNCT
admet-553	223	1	the	the	DET
admet-553	223	2	authors	author	NOUN
admet-553	223	3	used	use	VERB
admet-553	223	4	retention	retention	NOUN
admet-553	223	5	under	under	ADP
admet-553	223	6	the	the	DET
admet-553	223	7	different	different	ADJ
admet-553	223	8	chromatographic	chromatographic	ADJ
admet-553	223	9	conditions	condition	NOUN
admet-553	223	10	as	as	SCONJ
admet-553	223	11	lipophilicity	lipophilicity	NOUN
admet-553	223	12	indices	indice	VERB
admet-553	223	13	for	for	ADP
admet-553	223	14	15	15	NUM
admet-553	223	15	phenoxyacetic	phenoxyacetic	ADJ
admet-553	223	16	and	and	CCONJ
admet-553	223	17	carbamic	carbamic	ADJ
admet-553	223	18	acid	acid	NOUN
admet-553	223	19	derivatives	derivative	NOUN
admet-553	223	20	with	with	ADP
admet-553	223	21	potential	potential	ADJ
admet-553	223	22	use	use	NOUN
admet-553	223	23	as	as	ADP
admet-553	223	24	herbicides	herbicide	NOUN
admet-553	223	25	.	.	PUNCT
admet-553	224	1	comparison	comparison	NOUN
admet-553	224	2	with	with	ADP
admet-553	224	3	in	in	ADP
admet-553	224	4	silico	silico	NOUN
admet-553	224	5	calculated	calculate	VERB
admet-553	224	6	biological	biological	ADJ
admet-553	224	7	endpoints	endpoint	NOUN
admet-553	224	8	showed	show	VERB
admet-553	224	9	that	that	SCONJ
admet-553	224	10	all	all	PRON
admet-553	224	11	of	of	ADP
admet-553	224	12	the	the	DET
admet-553	224	13	chromatographic	chromatographic	ADJ
admet-553	224	14	indices	index	NOUN
admet-553	224	15	were	be	AUX
admet-553	224	16	promising	promise	VERB
admet-553	224	17	measures	measure	NOUN
admet-553	224	18	for	for	ADP
admet-553	224	19	the	the	DET
admet-553	224	20	partitioning	partitioning	NOUN
admet-553	224	21	of	of	ADP
admet-553	224	22	chemicals	chemical	NOUN
admet-553	224	23	in	in	ADP
admet-553	224	24	waterplant	waterplant	ADJ
admet-553	224	25	cuticle	cuticle	NOUN
admet-553	224	26	,	,	PUNCT
admet-553	224	27	waterhuman	waterhuman	ADJ
admet-553	224	28	serum	serum	NOUN
admet-553	224	29	albumin	albumin	PROPN
admet-553	224	30	and	and	CCONJ
admet-553	224	31	waterskin	waterskin	PROPN
admet-553	224	32	systems	system	NOUN
admet-553	224	33	[	[	X
admet-553	224	34	90	90	NUM
admet-553	224	35	]	]	PUNCT
admet-553	224	36	.	.	PUNCT
admet-553	225	1	cimpean	cimpean	PROPN
admet-553	225	2	et	et	PROPN
admet-553	225	3	al	al	PROPN
admet-553	225	4	.	.	PROPN
admet-553	225	5	correlated	correlate	VERB
admet-553	225	6	iam	iam	PROPN
admet-553	225	7	retention	retention	NOUN
admet-553	225	8	factors	factor	NOUN
admet-553	225	9	in	in	ADP
admet-553	225	10	the	the	DET
admet-553	225	11	presence	presence	NOUN
admet-553	225	12	of	of	ADP
admet-553	225	13	10	10	NUM
admet-553	225	14	%	%	NOUN
admet-553	225	15	methanol	methanol	NOUN
admet-553	225	16	with	with	ADP
admet-553	225	17	the	the	DET
admet-553	225	18	nonspecific	nonspecific	ADJ
admet-553	225	19	toxicity	toxicity	NOUN
admet-553	225	20	(	(	PUNCT
admet-553	225	21	-log	-log	PUNCT
admet-553	225	22	lc50	lc50	PROPN
admet-553	225	23	)	)	PUNCT
admet-553	225	24	of	of	ADP
admet-553	225	25	the	the	DET
admet-553	225	26	fathead	fathead	NOUN
admet-553	225	27	minnow	minnow	NOUN
admet-553	225	28	fish	fish	NOUN
admet-553	225	29	(	(	PUNCT
admet-553	225	30	pimephales	pimephale	NOUN
admet-553	225	31	promelas	promela	NOUN
admet-553	225	32	)	)	PUNCT
admet-553	226	1	[	[	X
admet-553	226	2	91	91	NUM
admet-553	226	3	]	]	PUNCT
admet-553	226	4	.	.	PUNCT
admet-553	227	1	hidalgorodriguez	hidalgorodriguez	NOUN
admet-553	227	2	et	et	PROPN
admet-553	227	3	al	al	PROPN
admet-553	227	4	.	.	PUNCT
admet-553	228	1	[	[	X
admet-553	228	2	92,93	92,93	X
admet-553	228	3	]	]	X
admet-553	228	4	and	and	CCONJ
admet-553	228	5	fernandez	fernandez	PROPN
admet-553	228	6	pumarega	pumarega	PROPN
admet-553	228	7	et	et	PROPN
admet-553	228	8	al	al	PROPN
admet-553	228	9	.	.	PUNCT
admet-553	229	1	[	[	X
admet-553	229	2	94	94	NUM
admet-553	229	3	]	]	SYM
admet-553	229	4	measured	measure	VERB
admet-553	229	5	retention	retention	NOUN
admet-553	229	6	on	on	ADP
admet-553	229	7	several	several	ADJ
admet-553	229	8	chromatographic	chromatographic	ADJ
admet-553	229	9	and	and	CCONJ
admet-553	229	10	electrophoretic	electrophoretic	ADJ
admet-553	229	11	systems	system	NOUN
admet-553	229	12	in	in	ADP
admet-553	229	13	order	order	NOUN
admet-553	229	14	to	to	PART
admet-553	229	15	find	find	VERB
admet-553	229	16	the	the	DET
admet-553	229	17	best	good	ADJ
admet-553	229	18	conditions	condition	NOUN
admet-553	229	19	to	to	PART
admet-553	229	20	emulate	emulate	VERB
admet-553	229	21	non	non	ADJ
admet-553	229	22	-	-	ADJ
admet-553	229	23	specific	specific	ADJ
admet-553	229	24	aquatic	aquatic	ADJ
admet-553	229	25	toxicity	toxicity	NOUN
admet-553	229	26	and	and	CCONJ
admet-553	229	27	soil	soil	NOUN
admet-553	229	28	sorption	sorption	NOUN
admet-553	229	29	.	.	PUNCT
admet-553	230	1	as	as	ADP
admet-553	230	2	aquatic	aquatic	ADJ
admet-553	230	3	toxicity	toxicity	NOUN
admet-553	230	4	endpoints	endpoint	NOUN
admet-553	230	5	,	,	PUNCT
admet-553	230	6	the	the	DET
admet-553	230	7	lethal	lethal	ADJ
admet-553	230	8	concentration	concentration	NOUN
admet-553	230	9	(	(	PUNCT
admet-553	230	10	lc50	lc50	PROPN
admet-553	230	11	)	)	PUNCT
admet-553	230	12	of	of	ADP
admet-553	230	13	fathead	fathead	NOUN
admet-553	230	14	minnow	minnow	NOUN
admet-553	230	15	fish	fish	NOUN
admet-553	231	1	[	[	X
admet-553	231	2	92	92	NUM
admet-553	231	3	]	]	PUNCT
admet-553	231	4	and	and	CCONJ
admet-553	231	5	the	the	DET
admet-553	231	6	tadpole	tadpole	NOUN
admet-553	231	7	narcosis	narcosis	NOUN
admet-553	231	8	concentration	concentration	NOUN
admet-553	231	9	(	(	PUNCT
admet-553	231	10	nar	nar	NOUN
admet-553	231	11	1	1	NUM
admet-553	231	12	log	log	NOUN
admet-553	231	13	c	c	NOUN
admet-553	231	14			NOUN
admet-553	232	1			PROPN
admet-553	232	2			PROPN
admet-553	232	3			PROPN
admet-553	233	1			PROPN
admet-553	233	2			NOUN
admet-553	233	3	)	)	PUNCT
admet-553	234	1	[	[	X
admet-553	234	2	94	94	NUM
admet-553	234	3	]	]	PUNCT
admet-553	234	4	were	be	AUX
admet-553	234	5	used	use	VERB
admet-553	234	6	,	,	PUNCT
admet-553	234	7	while	while	SCONJ
admet-553	234	8	soil	soil	NOUN
admet-553	234	9	sorption	sorption	NOUN
admet-553	234	10	was	be	AUX
admet-553	234	11	also	also	ADV
admet-553	234	12	considered	consider	VERB
admet-553	234	13	,	,	PUNCT
admet-553	234	14	expressed	express	VERB
admet-553	234	15	by	by	ADP
admet-553	234	16	the	the	DET
admet-553	234	17	logarithm	logarithm	NOUN
admet-553	234	18	of	of	ADP
admet-553	234	19	the	the	DET
admet-553	234	20	organic	organic	ADJ
admet-553	234	21	carbon	carbon	NOUN
admet-553	234	22	normalized	normalize	VERB
admet-553	234	23	sorption	sorption	NOUN
admet-553	234	24	coefficient	coefficient	NOUN
admet-553	234	25	,	,	PUNCT
admet-553	234	26	log	log	PROPN
admet-553	234	27	koc	koc	PROPN
admet-553	235	1	[	[	X
admet-553	235	2	93	93	NUM
admet-553	235	3	]	]	PUNCT
admet-553	235	4	.	.	PUNCT
admet-553	236	1	chromatographic	chromatographic	ADJ
admet-553	236	2	and	and	CCONJ
admet-553	236	3	ecotoxicological	ecotoxicological	ADJ
admet-553	236	4	data	datum	NOUN
admet-553	236	5	were	be	AUX
admet-553	236	6	submitted	submit	VERB
admet-553	236	7	to	to	ADP
admet-553	236	8	lser	lser	VERB
admet-553	236	9	analysis	analysis	NOUN
admet-553	236	10	.	.	PUNCT
admet-553	237	1	comparison	comparison	NOUN
admet-553	237	2	of	of	ADP
admet-553	237	3	the	the	DET
admet-553	237	4	solvation	solvation	NOUN
admet-553	237	5	parameter	parameter	NOUN
admet-553	237	6	models	model	NOUN
admet-553	237	7	(	(	PUNCT
admet-553	237	8	spm	spm	PROPN
admet-553	237	9	)	)	PUNCT
admet-553	237	10	was	be	AUX
admet-553	237	11	based	base	VERB
admet-553	237	12	on	on	ADP
admet-553	237	13	the	the	DET
admet-553	237	14	distance	distance	NOUN
admet-553	237	15	parameter	parameter	NOUN
admet-553	237	16	d	d	PROPN
admet-553	237	17	(	(	PUNCT
admet-553	237	18	the	the	DET
admet-553	237	19	difference	difference	NOUN
admet-553	237	20	between	between	ADP
admet-553	237	21	the	the	DET
admet-553	237	22	coefficients	coefficient	NOUN
admet-553	237	23	of	of	ADP
admet-553	237	24	the	the	DET
admet-553	237	25	respective	respective	ADJ
admet-553	237	26	spms	spm	NOUN
admet-553	237	27	)	)	PUNCT
admet-553	237	28	,	,	PUNCT
admet-553	237	29	on	on	ADP
admet-553	237	30	the	the	DET
admet-553	237	31	precision	precision	NOUN
admet-553	237	32	of	of	ADP
admet-553	237	33	biological	biological	ADJ
admet-553	237	34	-	-	PUNCT
admet-553	237	35	chromatographic	chromatographic	ADJ
admet-553	237	36	correlations	correlation	NOUN
admet-553	237	37	,	,	PUNCT
admet-553	237	38	on	on	ADP
admet-553	237	39	principal	principal	ADJ
admet-553	237	40	component	component	NOUN
admet-553	237	41	analysis	analysis	NOUN
admet-553	237	42	(	(	PUNCT
admet-553	237	43	pca	pca	NOUN
admet-553	237	44	)	)	PUNCT
admet-553	237	45	of	of	ADP
admet-553	237	46	the	the	DET
admet-553	237	47	coefficients	coefficient	NOUN
admet-553	237	48	of	of	ADP
admet-553	237	49	the	the	DET
admet-553	237	50	compared	compare	VERB
admet-553	237	51	systems	system	NOUN
admet-553	237	52	and	and	CCONJ
admet-553	237	53	on	on	ADP
admet-553	237	54	dendrogram	dendrogram	NOUN
admet-553	237	55	plots	plot	NOUN
admet-553	237	56	.	.	PUNCT
admet-553	238	1	finally	finally	ADV
admet-553	238	2	,	,	PUNCT
admet-553	238	3	the	the	DET
admet-553	238	4	chromatographic	chromatographic	ADJ
admet-553	238	5	indices	index	NOUN
admet-553	238	6	selected	select	VERB
admet-553	238	7	according	accord	VERB
admet-553	238	8	to	to	ADP
admet-553	238	9	the	the	DET
admet-553	238	10	above	above	ADJ
admet-553	238	11	tools	tool	NOUN
admet-553	238	12	were	be	AUX
admet-553	238	13	directly	directly	ADV
admet-553	238	14	correlated	correlate	VERB
admet-553	238	15	with	with	ADP
admet-553	238	16	the	the	DET
admet-553	238	17	ecotoxicological	ecotoxicological	ADJ
admet-553	238	18	data	datum	NOUN
admet-553	238	19	.	.	PUNCT
admet-553	239	1	for	for	ADP
admet-553	239	2	aquatic	aquatic	ADJ
admet-553	239	3	toxicity	toxicity	NOUN
admet-553	239	4	,	,	PUNCT
admet-553	239	5	iam	iam	PROPN
admet-553	239	6	chromatography	chromatography	NOUN
admet-553	239	7	along	along	ADP
admet-553	239	8	with	with	ADP
admet-553	239	9	micellar	micellar	ADJ
admet-553	239	10	electrokinetic	electrokinetic	ADJ
admet-553	239	11	chromatography	chromatography	NOUN
admet-553	239	12	based	base	VERB
admet-553	239	13	on	on	ADP
admet-553	239	14	sodium	sodium	NOUN
admet-553	239	15	taurocholate	taurocholate	NOUN
admet-553	239	16	showed	show	VERB
admet-553	239	17	the	the	DET
admet-553	239	18	best	good	ADJ
admet-553	239	19	predictive	predictive	ADJ
admet-553	239	20	performance	performance	NOUN
admet-553	239	21	[	[	X
admet-553	239	22	92,94	92,94	NUM
admet-553	239	23	]	]	PUNCT
admet-553	239	24	.	.	PUNCT
admet-553	240	1	furthermore	furthermore	ADV
admet-553	240	2	,	,	PUNCT
admet-553	240	3	iam	iam	PROPN
admet-553	240	4	and	and	CCONJ
admet-553	240	5	electrokinetic	electrokinetic	ADJ
admet-553	240	6	chromatography	chromatography	NOUN
admet-553	240	7	based	base	VERB
admet-553	240	8	either	either	CCONJ
admet-553	240	9	on	on	ADP
admet-553	240	10	sodium	sodium	NOUN
admet-553	240	11	dodecyl	dodecyl	INTJ
admet-553	240	12	sulfate	sulfate	NOUN
admet-553	240	13	or	or	CCONJ
admet-553	240	14	sodium	sodium	NOUN
admet-553	240	15	taurocholate	taurocholate	NOUN
admet-553	240	16	provided	provide	VERB
admet-553	240	17	the	the	DET
admet-553	240	18	most	most	ADV
admet-553	240	19	precise	precise	ADJ
admet-553	240	20	correlation	correlation	NOUN
admet-553	240	21	models	model	NOUN
admet-553	240	22	for	for	ADP
admet-553	240	23	soil	soil	NOUN
admet-553	240	24	sorption	sorption	NOUN
admet-553	240	25	.	.	PUNCT
admet-553	241	1	especially	especially	ADV
admet-553	241	2	,	,	PUNCT
admet-553	241	3	the	the	DET
admet-553	241	4	iam	iam	PROPN
admet-553	241	5	model	model	NOUN
admet-553	241	6	showed	show	VERB
admet-553	241	7	the	the	DET
admet-553	241	8	lowest	low	ADJ
admet-553	241	9	experimental	experimental	ADJ
admet-553	241	10	error	error	NOUN
admet-553	241	11	as	as	SCONJ
admet-553	241	12	reflected	reflect	VERB
admet-553	241	13	in	in	ADP
admet-553	241	14	the	the	DET
admet-553	241	15	standard	standard	ADJ
admet-553	241	16	deviation	deviation	NOUN
admet-553	241	17	between	between	ADP
admet-553	241	18	the	the	DET
admet-553	241	19	observed	observe	VERB
admet-553	241	20	and	and	CCONJ
admet-553	241	21	calculated	calculated	ADJ
admet-553	241	22	data	datum	NOUN
admet-553	241	23	[	[	X
admet-553	241	24	92	92	NUM
admet-553	241	25	]	]	PUNCT
admet-553	241	26	.	.	PUNCT
admet-553	242	1	the	the	DET
admet-553	242	2	potential	potential	NOUN
admet-553	242	3	of	of	ADP
admet-553	242	4	iam	iam	PROPN
admet-553	242	5	chromatography	chromatography	NOUN
admet-553	242	6	to	to	PART
admet-553	242	7	predict	predict	VERB
admet-553	242	8	bioconcentration	bioconcentration	NOUN
admet-553	242	9	of	of	ADP
admet-553	242	10	pharmaceutical	pharmaceutical	NOUN
admet-553	242	11	compounds	compound	NOUN
admet-553	242	12	in	in	ADP
admet-553	242	13	aquatic	aquatic	ADJ
admet-553	242	14	organisms	organism	NOUN
admet-553	242	15	was	be	AUX
admet-553	242	16	recently	recently	ADV
admet-553	242	17	investigated	investigate	VERB
admet-553	242	18	by	by	ADP
admet-553	242	19	our	our	PRON
admet-553	242	20	group	group	NOUN
admet-553	242	21	[	[	X
admet-553	242	22	21	21	NUM
admet-553	242	23	]	]	PUNCT
admet-553	242	24	.	.	PUNCT
admet-553	243	1	since	since	SCONJ
admet-553	243	2	very	very	ADV
admet-553	243	3	limited	limited	ADJ
admet-553	243	4	experimental	experimental	ADJ
admet-553	243	5	bioconcentration	bioconcentration	NOUN
admet-553	243	6	factors	factor	NOUN
admet-553	243	7	(	(	PUNCT
admet-553	243	8	bcf	bcf	NOUN
admet-553	243	9	)	)	PUNCT
admet-553	243	10	of	of	ADP
admet-553	243	11	pharmaceutical	pharmaceutical	ADJ
admet-553	243	12	compounds	compound	NOUN
admet-553	243	13	are	be	AUX
admet-553	243	14	available	available	ADJ
admet-553	243	15	,	,	PUNCT
admet-553	243	16	bcf	bcf	PROPN
admet-553	243	17	values	value	NOUN
admet-553	243	18	predicted	predict	VERB
admet-553	243	19	by	by	ADP
admet-553	243	20	epi	epi	NOUN
admet-553	243	21	suite	suite	NOUN
admet-553	243	22	software	software	NOUN
admet-553	243	23	were	be	AUX
admet-553	243	24	used	use	VERB
admet-553	243	25	to	to	PART
admet-553	243	26	compile	compile	VERB
admet-553	243	27	a	a	DET
admet-553	243	28	data	data	NOUN
admet-553	243	29	set	set	VERB
admet-553	243	30	of	of	ADP
admet-553	243	31	125	125	NUM
admet-553	243	32	structurally	structurally	ADV
admet-553	243	33	diverse	diverse	ADJ
admet-553	243	34	drugs	drug	NOUN
admet-553	243	35	.	.	PUNCT
admet-553	244	1	epi	epi	NOUN
admet-553	244	2	suite	suite	PROPN
admet-553	244	3	software	software	NOUN
admet-553	244	4	employs	employ	VERB
admet-553	244	5	log	log	VERB
admet-553	244	6	kow	kow	PROPN
admet-553	244	7	(	(	PUNCT
admet-553	244	8	log	log	PROPN
admet-553	244	9	p	p	NOUN
admet-553	244	10	calculated	calculate	VERB
admet-553	244	11	according	accord	VERB
admet-553	244	12	to	to	ADP
admet-553	244	13	meylan	meylan	PROPN
admet-553	244	14	et	et	PROPN
admet-553	244	15	al	al	PROPN
admet-553	244	16	.	.	PUNCT
admet-553	245	1	[	[	X
admet-553	245	2	84	84	NUM
admet-553	245	3	]	]	SYM
admet-553	245	4	)	)	PUNCT
admet-553	245	5	as	as	ADP
admet-553	245	6	a	a	DET
admet-553	245	7	major	major	ADJ
admet-553	245	8	descriptor	descriptor	NOUN
admet-553	245	9	for	for	ADP
admet-553	245	10	bcf	bcf	NOUN
admet-553	245	11	calculations	calculation	NOUN
admet-553	245	12	,	,	PUNCT
admet-553	245	13	while	while	SCONJ
admet-553	245	14	for	for	ADP
admet-553	245	15	ionic	ionic	ADJ
admet-553	245	16	and	and	CCONJ
admet-553	245	17	highly	highly	ADV
admet-553	245	18	hydrophilic	hydrophilic	ADJ
admet-553	245	19	compounds	compound	VERB
admet-553	245	20	an	an	DET
admet-553	245	21	arbitrary	arbitrary	ADJ
admet-553	245	22	value	value	NOUN
admet-553	245	23	of	of	ADP
admet-553	245	24	log	log	NOUN
admet-553	245	25	bcf	bcf	NOUN
admet-553	245	26	=	=	SYM
admet-553	245	27	0.50	0.50	NUM
admet-553	245	28	is	be	AUX
admet-553	245	29	assigned	assign	VERB
admet-553	245	30	by	by	ADP
admet-553	245	31	the	the	DET
admet-553	245	32	software	software	NOUN
admet-553	245	33	.	.	PUNCT
admet-553	246	1	therefore	therefore	ADV
admet-553	246	2	,	,	PUNCT
admet-553	246	3	such	such	ADJ
admet-553	246	4	drugs	drug	NOUN
admet-553	246	5	were	be	AUX
admet-553	246	6	excluded	exclude	VERB
admet-553	246	7	from	from	ADP
admet-553	246	8	the	the	DET
admet-553	246	9	analysis	analysis	NOUN
admet-553	246	10	and	and	CCONJ
admet-553	246	11	were	be	AUX
admet-553	246	12	posteriori	posteriori	NOUN
admet-553	246	13	predicted	predict	VERB
admet-553	246	14	by	by	ADP
admet-553	246	15	the	the	DET
admet-553	246	16	iam	iam	PROPN
admet-553	246	17	model	model	NOUN
admet-553	246	18	.	.	PUNCT
admet-553	247	1	highly	highly	ADV
admet-553	247	2	significant	significant	ADJ
admet-553	247	3	linear	linear	NOUN
admet-553	247	4	log	log	VERB
admet-553	247	5	bcf/	bcf/	NUM
admet-553	247	6	log	log	NOUN
admet-553	247	7	kw(iam	kw(iam	NOUN
admet-553	247	8	)	)	PUNCT
admet-553	247	9	values	value	NOUN
admet-553	247	10	were	be	AUX
admet-553	247	11	established	establish	VERB
admet-553	247	12	.	.	PUNCT
admet-553	248	1	the	the	DET
admet-553	248	2	constructed	constructed	ADJ
admet-553	248	3	model	model	NOUN
admet-553	248	4	was	be	AUX
admet-553	248	5	improved	improve	VERB
admet-553	248	6	by	by	ADP
admet-553	248	7	the	the	DET
admet-553	248	8	inclusion	inclusion	NOUN
admet-553	248	9	of	of	ADP
admet-553	248	10	the	the	DET
admet-553	248	11	parameter	parameter	NOUN
admet-553	248	12	biowin5	biowin5	PROPN
admet-553	248	13	,	,	PUNCT
admet-553	248	14	which	which	PRON
admet-553	248	15	expresses	express	VERB
admet-553	248	16	the	the	DET
admet-553	248	17	decrease	decrease	NOUN
admet-553	248	18	in	in	ADP
admet-553	248	19	the	the	DET
admet-553	248	20	bioaccumulation	bioaccumulation	NOUN
admet-553	248	21	tendency	tendency	NOUN
admet-553	248	22	as	as	ADP
admet-553	248	23	a	a	DET
admet-553	248	24	result	result	NOUN
admet-553	248	25	of	of	ADP
admet-553	248	26	the	the	DET
admet-553	248	27	degradation	degradation	NOUN
admet-553	248	28	potential	potential	NOUN
admet-553	248	29	of	of	ADP
admet-553	248	30	the	the	DET
admet-553	248	31	compounds	compound	NOUN
admet-553	248	32	.	.	PUNCT
admet-553	249	1	biowin5	biowin5	PROPN
admet-553	249	2	is	be	AUX
admet-553	249	3	predicted	predict	VERB
admet-553	249	4	by	by	ADP
admet-553	249	5	the	the	DET
admet-553	249	6	epi	epi	NOUN
admet-553	249	7	suite	suite	NOUN
admet-553	249	8	software	software	NOUN
admet-553	249	9	and	and	CCONJ
admet-553	249	10	is	be	AUX
admet-553	249	11	included	include	VERB
admet-553	249	12	also	also	ADV
admet-553	249	13	in	in	ADP
admet-553	249	14	the	the	DET
admet-553	249	15	epi	epi	NOUN
admet-553	249	16	-	-	PROPN
admet-553	249	17	bcf	bcf	ADJ
admet-553	249	18	model	model	NOUN
admet-553	249	19	.	.	PUNCT
admet-553	250	1	the	the	DET
admet-553	250	2	log	log	NOUN
admet-553	250	3	bcf/	bcf/	NUM
admet-553	250	4	log	log	NOUN
admet-553	250	5	kw(iam	kw(iam	NOUN
admet-553	250	6	)	)	PUNCT
admet-553	250	7	relationship	relationship	NOUN
admet-553	250	8	is	be	AUX
admet-553	250	9	shown	show	VERB
admet-553	250	10	in	in	ADP
admet-553	250	11	eq.(13	eq.(13	NOUN
admet-553	250	12	)	)	PUNCT
admet-553	251	1	[	[	X
admet-553	251	2	21	21	NUM
admet-553	251	3	]	]	PUNCT
admet-553	251	4	:	:	PUNCT
admet-553	251	5	log	log	VERB
admet-553	251	6	bcf	bcf	NOUN
admet-553	251	7	=	=	SYM
admet-553	251	8	0.85	0.85	NUM
admet-553	251	9	·	·	PUNCT
admet-553	251	10	log	log	VERB
admet-553	251	11	7.4	7.4	NUM
admet-553	251	12	w(iam)k	w(iam)k	NOUN
admet-553	251	13	0.47	0.47	NUM
admet-553	251	14	·	·	PUNCT
admet-553	251	15	biowin5	biowin5	VERB
admet-553	252	1	+	+	CCONJ
admet-553	252	2	0.08	0.08	NUM
admet-553	252	3	(	(	PUNCT
admet-553	252	4	13	13	NUM
admet-553	252	5	)	)	PUNCT
admet-553	252	6	(	(	PUNCT
admet-553	252	7	n=	n=	ADJ
admet-553	252	8	77	77	NUM
admet-553	252	9	,	,	PUNCT
admet-553	252	10	r2=	r2=	PROPN
admet-553	252	11	0.761	0.761	NUM
admet-553	252	12	,	,	PUNCT
admet-553	252	13	s=	s=	NOUN
admet-553	252	14	0.437	0.437	NUM
admet-553	252	15	)	)	PUNCT
admet-553	252	16	admet	admet	PROPN
admet-553	252	17	&	&	CCONJ
admet-553	252	18	dmpk	dmpk	PROPN
admet-553	252	19	6(3	6(3	PROPN
admet-553	252	20	)	)	PUNCT
admet-553	252	21	(	(	PUNCT
admet-553	252	22	2018	2018	NUM
admet-553	252	23	)	)	PUNCT
admet-553	252	24	225	225	NUM
admet-553	252	25	-	-	SYM
admet-553	252	26	241	241	NUM
admet-553	252	27	iam	iam	PROPN
admet-553	252	28	chromatography	chromatography	NOUN
admet-553	252	29	in	in	ADP
admet-553	252	30	medicinal	medicinal	ADJ
admet-553	252	31	chemistry	chemistry	NOUN
admet-553	252	32	and	and	CCONJ
admet-553	252	33	environment	environment	NOUN
admet-553	252	34	doi	doi	PROPN
admet-553	252	35	:	:	PUNCT
admet-553	252	36	10.5599	10.5599	NUM
admet-553	252	37	/	/	SYM
admet-553	252	38	admet.553	admet.553	NOUN
admet-553	252	39	235	235	NUM
admet-553	252	40	validation	validation	NOUN
admet-553	252	41	of	of	ADP
admet-553	252	42	the	the	DET
admet-553	252	43	constructed	construct	VERB
admet-553	252	44	models	model	NOUN
admet-553	252	45	was	be	AUX
admet-553	252	46	based	base	VERB
admet-553	252	47	on	on	ADP
admet-553	252	48	a	a	DET
admet-553	252	49	test	test	NOUN
admet-553	252	50	set	set	NOUN
admet-553	252	51	of	of	ADP
admet-553	252	52	drugs	drug	NOUN
admet-553	252	53	with	with	ADP
admet-553	252	54	experimentally	experimentally	ADV
admet-553	252	55	determined	determine	VERB
admet-553	252	56	bcf	bcf	NOUN
admet-553	252	57	values	value	NOUN
admet-553	252	58	reported	report	VERB
admet-553	252	59	in	in	ADP
admet-553	252	60	the	the	DET
admet-553	252	61	literature	literature	NOUN
admet-553	252	62	.	.	PUNCT
admet-553	253	1	predictions	prediction	NOUN
admet-553	253	2	of	of	ADP
admet-553	253	3	the	the	DET
admet-553	253	4	test	test	NOUN
admet-553	253	5	set	set	NOUN
admet-553	253	6	were	be	AUX
admet-553	253	7	compared	compare	VERB
admet-553	253	8	with	with	ADP
admet-553	253	9	those	those	PRON
admet-553	253	10	provided	provide	VERB
admet-553	253	11	by	by	ADP
admet-553	253	12	the	the	DET
admet-553	253	13	epi	epi	NOUN
admet-553	253	14	software	software	NOUN
admet-553	253	15	and	and	CCONJ
admet-553	253	16	in	in	ADP
admet-553	253	17	most	most	ADJ
admet-553	253	18	cases	case	NOUN
admet-553	253	19	,	,	PUNCT
admet-553	253	20	they	they	PRON
admet-553	253	21	were	be	AUX
admet-553	253	22	in	in	ADP
admet-553	253	23	favour	favour	NOUN
admet-553	253	24	of	of	ADP
admet-553	253	25	the	the	DET
admet-553	253	26	iam	iam	PROPN
admet-553	253	27	model	model	NOUN
admet-553	253	28	.	.	PUNCT
admet-553	254	1	this	this	PRON
admet-553	254	2	can	can	AUX
admet-553	254	3	be	be	AUX
admet-553	254	4	explained	explain	VERB
admet-553	254	5	on	on	ADP
admet-553	254	6	the	the	DET
admet-553	254	7	basis	basis	NOUN
admet-553	254	8	that	that	PRON
admet-553	254	9	log	log	VERB
admet-553	254	10	kw(iam	kw(iam	NOUN
admet-553	254	11	)	)	PUNCT
admet-553	254	12	values	value	NOUN
admet-553	254	13	involved	involve	VERB
admet-553	254	14	electrostatic	electrostatic	ADJ
admet-553	254	15	interactions	interaction	NOUN
admet-553	254	16	due	due	ADP
admet-553	254	17	to	to	ADP
admet-553	254	18	ionization	ionization	NOUN
admet-553	254	19	of	of	ADP
admet-553	254	20	the	the	DET
admet-553	254	21	species	specie	NOUN
admet-553	254	22	at	at	ADP
admet-553	254	23	a	a	DET
admet-553	254	24	ph	ph	NOUN
admet-553	254	25	close	close	NOUN
admet-553	254	26	to	to	ADP
admet-553	254	27	those	those	PRON
admet-553	254	28	of	of	ADP
admet-553	254	29	a	a	DET
admet-553	254	30	marine/	marine/	NUM
admet-553	254	31	freshwater	freshwater	NOUN
admet-553	254	32	environment	environment	NOUN
admet-553	254	33	,	,	PUNCT
admet-553	254	34	while	while	SCONJ
admet-553	254	35	log	log	VERB
admet-553	254	36	kow	kow	PROPN
admet-553	254	37	is	be	AUX
admet-553	254	38	refers	refer	VERB
admet-553	254	39	only	only	ADV
admet-553	254	40	to	to	ADP
admet-553	254	41	a	a	DET
admet-553	254	42	neutral	neutral	ADJ
admet-553	254	43	species	specie	NOUN
admet-553	254	44	expressing	express	VERB
admet-553	254	45	only	only	ADV
admet-553	254	46	a	a	DET
admet-553	254	47	lipiddriven	lipiddriven	ADJ
admet-553	254	48	bioconcentration	bioconcentration	NOUN
admet-553	254	49	[	[	X
admet-553	254	50	95	95	NUM
admet-553	254	51	]	]	PUNCT
admet-553	254	52	.	.	PUNCT
admet-553	255	1	in	in	ADP
admet-553	255	2	recent	recent	ADJ
admet-553	255	3	work	work	NOUN
admet-553	255	4	by	by	ADP
admet-553	255	5	russo	russo	PROPN
admet-553	255	6	et	et	PROPN
admet-553	255	7	al	al	PROPN
admet-553	255	8	.	.	PUNCT
admet-553	256	1	[	[	X
admet-553	256	2	96	96	NUM
admet-553	256	3	]	]	PUNCT
admet-553	256	4	,	,	PUNCT
admet-553	256	5	the	the	DET
admet-553	256	6	iam	iam	PROPN
admet-553	256	7	phospholipophilicity	phospholipophilicity	NOUN
admet-553	256	8	of	of	ADP
admet-553	256	9	seven	seven	NUM
admet-553	256	10	bisphenol	bisphenol	NOUN
admet-553	256	11	a	a	DET
admet-553	256	12	analogues	analogue	NOUN
admet-553	256	13	was	be	AUX
admet-553	256	14	compared	compare	VERB
admet-553	256	15	with	with	ADP
admet-553	256	16	toxicity	toxicity	NOUN
admet-553	256	17	investigated	investigate	VERB
admet-553	256	18	on	on	ADP
admet-553	256	19	four	four	NUM
admet-553	256	20	different	different	ADJ
admet-553	256	21	cell	cell	NOUN
admet-553	256	22	cultures	culture	NOUN
admet-553	256	23	.	.	PUNCT
admet-553	257	1	results	result	NOUN
admet-553	257	2	showed	show	VERB
admet-553	257	3	that	that	SCONJ
admet-553	257	4	the	the	DET
admet-553	257	5	ranking	ranking	NOUN
admet-553	257	6	of	of	ADP
admet-553	257	7	toxicity	toxicity	NOUN
admet-553	257	8	according	accord	VERB
admet-553	257	9	to	to	ADP
admet-553	257	10	the	the	DET
admet-553	257	11	cell	cell	NOUN
admet-553	257	12	cultures	culture	NOUN
admet-553	257	13	was	be	AUX
admet-553	257	14	partly	partly	ADV
admet-553	257	15	consistent	consistent	ADJ
admet-553	257	16	with	with	ADP
admet-553	257	17	the	the	DET
admet-553	257	18	iam	iam	PROPN
admet-553	257	19	retention	retention	NOUN
admet-553	257	20	,	,	PUNCT
admet-553	257	21	indicating	indicate	VERB
admet-553	257	22	that	that	SCONJ
admet-553	257	23	toxicity	toxicity	NOUN
admet-553	257	24	increases	increase	NOUN
admet-553	257	25	with	with	ADP
admet-553	257	26	increasing	increase	VERB
admet-553	257	27	membrane	membrane	ADJ
admet-553	257	28	affinity	affinity	NOUN
admet-553	258	1	[	[	X
admet-553	258	2	96	96	NUM
admet-553	258	3	]	]	PUNCT
admet-553	258	4	.	.	PUNCT
admet-553	259	1	unpublished	unpublished	ADJ
admet-553	259	2	results	result	NOUN
admet-553	259	3	from	from	ADP
admet-553	259	4	our	our	PRON
admet-553	259	5	research	research	NOUN
admet-553	259	6	group	group	NOUN
admet-553	259	7	have	have	AUX
admet-553	259	8	revealed	reveal	VERB
admet-553	259	9	the	the	DET
admet-553	259	10	ability	ability	NOUN
admet-553	259	11	of	of	ADP
admet-553	259	12	iam	iam	PROPN
admet-553	259	13	chromatography	chromatography	NOUN
admet-553	259	14	to	to	AUX
admet-553	259	15	model	model	VERB
admet-553	259	16	median	median	ADJ
admet-553	259	17	toxicity	toxicity	NOUN
admet-553	259	18	of	of	ADP
admet-553	259	19	a	a	DET
admet-553	259	20	series	series	NOUN
admet-553	259	21	of	of	ADP
admet-553	259	22	structurally	structurally	ADV
admet-553	259	23	diverse	diverse	ADJ
admet-553	259	24	pesticides	pesticide	NOUN
admet-553	259	25	in	in	ADP
admet-553	259	26	aquatic	aquatic	ADJ
admet-553	259	27	organisms	organism	NOUN
admet-553	259	28	,	,	PUNCT
admet-553	259	29	involving	involve	VERB
admet-553	259	30	fish	fish	NOUN
admet-553	259	31	species	specie	NOUN
admet-553	259	32	(	(	PUNCT
admet-553	259	33	e.g.	e.g.	ADV
admet-553	259	34	fathead	fathead	NOUN
admet-553	259	35	minnow	minnow	NOUN
admet-553	259	36	and	and	CCONJ
admet-553	259	37	rainbow	rainbow	NOUN
admet-553	259	38	trout	trout	NOUN
admet-553	259	39	)	)	PUNCT
admet-553	259	40	,	,	PUNCT
admet-553	259	41	eastern	eastern	ADJ
admet-553	259	42	oyster	oyster	NOUN
admet-553	259	43	and	and	CCONJ
admet-553	259	44	water	water	NOUN
admet-553	259	45	flea	flea	NOUN
admet-553	259	46	as	as	ADV
admet-553	259	47	well	well	ADV
admet-553	259	48	as	as	ADP
admet-553	259	49	in	in	ADP
admet-553	259	50	honey	honey	NOUN
admet-553	259	51	bee	bee	NOUN
admet-553	259	52	.	.	PUNCT
admet-553	260	1	in	in	ADP
admet-553	260	2	comparison	comparison	NOUN
admet-553	260	3	with	with	ADP
admet-553	260	4	octanol	octanol	NOUN
admet-553	260	5	-	-	PUNCT
admet-553	260	6	water	water	NOUN
admet-553	260	7	partitioning	partitioning	NOUN
admet-553	260	8	,	,	PUNCT
admet-553	260	9	models	model	NOUN
admet-553	260	10	based	base	VERB
admet-553	260	11	on	on	ADP
admet-553	260	12	log	log	PROPN
admet-553	260	13	kw(iam	kw(iam	NOUN
admet-553	260	14	)	)	PUNCT
admet-553	260	15	demonstrate	demonstrate	VERB
admet-553	260	16	equal	equal	ADJ
admet-553	260	17	or	or	CCONJ
admet-553	260	18	superior	superior	ADJ
admet-553	260	19	statistics	statistic	NOUN
admet-553	260	20	and	and	CCONJ
admet-553	260	21	,	,	PUNCT
admet-553	260	22	in	in	ADP
admet-553	260	23	some	some	DET
admet-553	260	24	cases	case	NOUN
admet-553	260	25	,	,	PUNCT
admet-553	260	26	they	they	PRON
admet-553	260	27	do	do	AUX
admet-553	260	28	not	not	PART
admet-553	260	29	require	require	VERB
admet-553	260	30	the	the	DET
admet-553	260	31	use	use	NOUN
admet-553	260	32	of	of	ADP
admet-553	260	33	any	any	DET
admet-553	260	34	additional	additional	ADJ
admet-553	260	35	physicochemical	physicochemical	ADJ
admet-553	260	36	or	or	CCONJ
admet-553	260	37	topological	topological	ADJ
admet-553	260	38	parameters	parameter	NOUN
admet-553	260	39	[	[	X
admet-553	260	40	97	97	NUM
admet-553	260	41	]	]	PUNCT
admet-553	260	42	.	.	PUNCT
admet-553	261	1	conclusions	conclusion	NOUN
admet-553	261	2	the	the	DET
admet-553	261	3	nature	nature	NOUN
admet-553	261	4	of	of	ADP
admet-553	261	5	iam	iam	PROPN
admet-553	261	6	retention	retention	NOUN
admet-553	261	7	is	be	AUX
admet-553	261	8	between	between	ADP
admet-553	261	9	passive	passive	ADJ
admet-553	261	10	diffusion	diffusion	NOUN
admet-553	261	11	and	and	CCONJ
admet-553	261	12	binding	bind	VERB
admet-553	261	13	underlines	underline	VERB
admet-553	261	14	its	its	PRON
admet-553	261	15	potential	potential	NOUN
admet-553	261	16	for	for	ADP
admet-553	261	17	numerous	numerous	ADJ
admet-553	261	18	applications	application	NOUN
admet-553	261	19	in	in	ADP
admet-553	261	20	the	the	DET
admet-553	261	21	field	field	NOUN
admet-553	261	22	of	of	ADP
admet-553	261	23	pharmaceutical	pharmaceutical	NOUN
admet-553	261	24	and	and	CCONJ
admet-553	261	25	environmental	environmental	ADJ
admet-553	261	26	sciences	science	NOUN
admet-553	261	27	.	.	PUNCT
admet-553	262	1	an	an	DET
admet-553	262	2	increasing	increase	VERB
admet-553	262	3	number	number	NOUN
admet-553	262	4	of	of	ADP
admet-553	262	5	publications	publication	NOUN
admet-553	262	6	suggest	suggest	VERB
admet-553	262	7	that	that	SCONJ
admet-553	262	8	iam	iam	PROPN
admet-553	262	9	indices	index	NOUN
admet-553	262	10	can	can	AUX
admet-553	262	11	be	be	AUX
admet-553	262	12	an	an	DET
admet-553	262	13	equal	equal	ADJ
admet-553	262	14	or	or	CCONJ
admet-553	262	15	even	even	ADV
admet-553	262	16	a	a	DET
admet-553	262	17	more	more	ADV
admet-553	262	18	effective	effective	ADJ
admet-553	262	19	tool	tool	NOUN
admet-553	262	20	than	than	ADP
admet-553	262	21	traditional	traditional	ADJ
admet-553	262	22	octanol	octanol	NOUN
admet-553	262	23	-	-	PUNCT
admet-553	262	24	water	water	NOUN
admet-553	262	25	partitioning	partitioning	NOUN
admet-553	262	26	to	to	PART
admet-553	262	27	express	express	VERB
admet-553	262	28	the	the	DET
admet-553	262	29	passage	passage	NOUN
admet-553	262	30	of	of	ADP
admet-553	262	31	xenobiotics	xenobiotics	PROPN
admet-553	262	32	through	through	ADP
admet-553	262	33	biological	biological	ADJ
admet-553	262	34	membranes	membrane	NOUN
admet-553	262	35	and	and	CCONJ
admet-553	262	36	barriers	barrier	NOUN
admet-553	262	37	as	as	ADV
admet-553	262	38	well	well	ADV
admet-553	262	39	as	as	ADP
admet-553	262	40	drug	drug	NOUN
admet-553	262	41	-	-	PUNCT
admet-553	262	42	membrane	membrane	NOUN
admet-553	262	43	interactions	interaction	NOUN
admet-553	262	44	.	.	PUNCT
admet-553	263	1	the	the	DET
admet-553	263	2	great	great	ADJ
admet-553	263	3	advantages	advantage	NOUN
admet-553	263	4	are	be	AUX
admet-553	263	5	speed	speed	NOUN
admet-553	263	6	,	,	PUNCT
admet-553	263	7	reproducibility	reproducibility	NOUN
admet-553	263	8	and	and	CCONJ
admet-553	263	9	low	low	ADJ
admet-553	263	10	analyte	analyte	NOUN
admet-553	263	11	consumption	consumption	NOUN
admet-553	263	12	,	,	PUNCT
admet-553	263	13	as	as	ADV
admet-553	263	14	well	well	ADV
admet-553	263	15	as	as	ADP
admet-553	263	16	the	the	DET
admet-553	263	17	flexibility	flexibility	NOUN
admet-553	263	18	to	to	PART
admet-553	263	19	provide	provide	VERB
admet-553	263	20	more	more	ADJ
admet-553	263	21	than	than	ADP
admet-553	263	22	one	one	NUM
admet-553	263	23	index	index	NOUN
admet-553	263	24	(	(	PUNCT
admet-553	263	25	different	different	ADJ
admet-553	263	26	isocratic	isocratic	ADJ
admet-553	263	27	log	log	NOUN
admet-553	263	28	k(iam	k(iam	PROPN
admet-553	263	29	)	)	PUNCT
admet-553	263	30	,	,	PUNCT
admet-553	263	31	extrapolated	extrapolate	VERB
admet-553	263	32	log	log	NOUN
admet-553	263	33	kw(iam	kw(iam	NOUN
admet-553	263	34	)	)	PUNCT
admet-553	263	35	,	,	PUNCT
admet-553	263	36	chi(iam	chi(iam	PROPN
admet-553	263	37	)	)	PUNCT
admet-553	263	38	or	or	CCONJ
admet-553	263	39	δlog	δlog	PROPN
admet-553	263	40	kw(iam	kw(iam	PROPN
admet-553	263	41	)	)	PUNCT
admet-553	263	42	)	)	PUNCT
admet-553	263	43	which	which	PRON
admet-553	263	44	can	can	AUX
admet-553	263	45	be	be	AUX
admet-553	263	46	alternatively	alternatively	ADV
admet-553	263	47	used	use	VERB
admet-553	263	48	in	in	ADP
admet-553	263	49	correlation	correlation	NOUN
admet-553	263	50	with	with	ADP
admet-553	263	51	biological	biological	ADJ
admet-553	263	52	endpoints	endpoint	NOUN
admet-553	263	53	.	.	PUNCT
admet-553	264	1	in	in	ADP
admet-553	264	2	addition	addition	NOUN
admet-553	264	3	,	,	PUNCT
admet-553	264	4	pharmacokinetic	pharmacokinetic	ADJ
admet-553	264	5	parameters	parameter	NOUN
admet-553	264	6	like	like	ADP
admet-553	264	7	the	the	DET
admet-553	264	8	volume	volume	NOUN
admet-553	264	9	of	of	ADP
admet-553	264	10	distribution	distribution	NOUN
admet-553	264	11	or	or	CCONJ
admet-553	264	12	the	the	DET
admet-553	264	13	fraction	fraction	NOUN
admet-553	264	14	of	of	ADP
admet-553	264	15	unbound	unbound	NOUN
admet-553	264	16	in	in	ADP
admet-553	264	17	tissue	tissue	NOUN
admet-553	264	18	can	can	AUX
admet-553	264	19	be	be	AUX
admet-553	264	20	easily	easily	ADV
admet-553	264	21	estimated	estimate	VERB
admet-553	264	22	on	on	ADP
admet-553	264	23	the	the	DET
admet-553	264	24	basis	basis	NOUN
admet-553	264	25	of	of	ADP
admet-553	264	26	iam	iam	PROPN
admet-553	264	27	chromatographic	chromatographic	ADJ
admet-553	264	28	indices	index	NOUN
admet-553	264	29	,	,	PUNCT
admet-553	264	30	while	while	SCONJ
admet-553	264	31	they	they	PRON
admet-553	264	32	may	may	AUX
admet-553	264	33	also	also	ADV
admet-553	264	34	serve	serve	VERB
admet-553	264	35	for	for	ADP
admet-553	264	36	drug	drug	NOUN
admet-553	264	37	classification	classification	NOUN
admet-553	264	38	according	accord	VERB
admet-553	264	39	to	to	ADP
admet-553	264	40	certain	certain	ADJ
admet-553	264	41	properties	property	NOUN
admet-553	264	42	,	,	PUNCT
admet-553	264	43	such	such	ADJ
admet-553	264	44	as	as	ADP
admet-553	264	45	cns	cns	NOUN
admet-553	264	46	penetration	penetration	NOUN
admet-553	264	47	or	or	CCONJ
admet-553	264	48	phospholipidosis	phospholipidosis	NOUN
admet-553	264	49	potential	potential	NOUN
admet-553	264	50	.	.	PUNCT
admet-553	265	1	less	less	ADV
admet-553	265	2	investigated	investigate	VERB
admet-553	265	3	has	have	AUX
admet-553	265	4	been	be	AUX
admet-553	265	5	the	the	DET
admet-553	265	6	performance	performance	NOUN
admet-553	265	7	of	of	ADP
admet-553	265	8	iam	iam	PROPN
admet-553	265	9	chromatography	chromatography	NOUN
admet-553	265	10	in	in	ADP
admet-553	265	11	predicting	predict	VERB
admet-553	265	12	the	the	DET
admet-553	265	13	toxicity	toxicity	NOUN
admet-553	265	14	of	of	ADP
admet-553	265	15	candidate	candidate	NOUN
admet-553	265	16	drugs	drug	NOUN
admet-553	265	17	and	and	CCONJ
admet-553	265	18	ecotoxicity	ecotoxicity	NOUN
admet-553	265	19	of	of	ADP
admet-553	265	20	xenobiotics	xenobiotics	PROPN
admet-553	265	21	as	as	ADV
admet-553	265	22	well	well	ADV
admet-553	265	23	as	as	ADP
admet-553	265	24	the	the	DET
admet-553	265	25	combined	combined	ADJ
admet-553	265	26	use	use	NOUN
admet-553	265	27	of	of	ADP
admet-553	265	28	iam	iam	PROPN
admet-553	265	29	with	with	ADP
admet-553	265	30	other	other	ADJ
admet-553	265	31	biomimetic	biomimetic	ADJ
admet-553	265	32	chromatographic	chromatographic	ADJ
admet-553	265	33	indices	index	NOUN
admet-553	265	34	.	.	PUNCT
admet-553	266	1	such	such	ADJ
admet-553	266	2	studies	study	NOUN
admet-553	266	3	need	need	VERB
admet-553	266	4	to	to	PART
admet-553	266	5	be	be	AUX
admet-553	266	6	extended	extend	VERB
admet-553	266	7	to	to	ADP
admet-553	266	8	further	further	ADJ
admet-553	266	9	toxicity	toxicity	NOUN
admet-553	266	10	endpoints	endpoint	NOUN
admet-553	266	11	(	(	PUNCT
admet-553	266	12	e.g.	e.g.	ADV
admet-553	266	13	cardiotoxicity	cardiotoxicity	NOUN
admet-553	266	14	)	)	PUNCT
admet-553	266	15	and	and	CCONJ
admet-553	266	16	ecotoxicity	ecotoxicity	NOUN
admet-553	266	17	indices	index	NOUN
admet-553	266	18	on	on	ADP
admet-553	266	19	terrestrial	terrestrial	ADJ
admet-553	266	20	organisms	organism	NOUN
admet-553	266	21	(	(	PUNCT
admet-553	266	22	e.g.	e.g.	ADV
admet-553	266	23	honey	honey	NOUN
admet-553	266	24	bee	bee	PROPN
admet-553	266	25	)	)	PUNCT
admet-553	266	26	.	.	PUNCT
admet-553	267	1	the	the	DET
admet-553	267	2	promising	promising	ADJ
admet-553	267	3	results	result	NOUN
admet-553	267	4	obtained	obtain	VERB
admet-553	267	5	mainly	mainly	ADV
admet-553	267	6	in	in	ADP
admet-553	267	7	modelling	model	VERB
admet-553	267	8	pharmacokinetic	pharmacokinetic	ADJ
admet-553	267	9	and	and	CCONJ
admet-553	267	10	drug	drug	NOUN
admet-553	267	11	efficacy	efficacy	NOUN
admet-553	267	12	related	relate	VERB
admet-553	267	13	properties	property	NOUN
admet-553	267	14	and	and	CCONJ
admet-553	267	15	,	,	PUNCT
admet-553	267	16	more	more	ADV
admet-553	267	17	recently	recently	ADV
admet-553	267	18	,	,	PUNCT
admet-553	267	19	also	also	ADV
admet-553	267	20	in	in	ADP
admet-553	267	21	ecotoxicology	ecotoxicology	NOUN
admet-553	267	22	suggest	suggest	VERB
admet-553	267	23	that	that	SCONJ
admet-553	267	24	a	a	DET
admet-553	267	25	broader	broad	ADJ
admet-553	267	26	application	application	NOUN
admet-553	267	27	of	of	ADP
admet-553	267	28	iam	iam	PROPN
admet-553	267	29	chromatography	chromatography	NOUN
admet-553	267	30	in	in	ADP
admet-553	267	31	early	early	ADJ
admet-553	267	32	drug	drug	NOUN
admet-553	267	33	discovery	discovery	NOUN
admet-553	267	34	processes	process	NOUN
admet-553	267	35	and	and	CCONJ
admet-553	267	36	in	in	ADP
admet-553	267	37	environmental	environmental	ADJ
admet-553	267	38	science	science	NOUN
admet-553	267	39	may	may	AUX
admet-553	267	40	save	save	VERB
admet-553	267	41	time	time	NOUN
admet-553	267	42	and	and	CCONJ
admet-553	267	43	money	money	NOUN
admet-553	267	44	in	in	ADP
admet-553	267	45	initial	initial	ADJ
admet-553	267	46	drug	drug	NOUN
admet-553	267	47	candidate	candidate	NOUN
admet-553	267	48	selection	selection	NOUN
admet-553	267	49	and	and	CCONJ
admet-553	267	50	contribute	contribute	VERB
admet-553	267	51	to	to	ADP
admet-553	267	52	a	a	DET
admet-553	267	53	reduced	reduce	VERB
admet-553	267	54	risk	risk	NOUN
admet-553	267	55	hazard	hazard	NOUN
admet-553	267	56	of	of	ADP
admet-553	267	57	chemicals	chemical	NOUN
admet-553	267	58	.	.	PUNCT
admet-553	268	1	the	the	DET
admet-553	268	2	high	high	ADJ
admet-553	268	3	intralaboratory	intralaboratory	ADJ
admet-553	268	4	reproducibility	reproducibility	NOUN
admet-553	268	5	of	of	ADP
admet-553	268	6	logkw(iam	logkw(iam	PROPN
admet-553	268	7	)	)	PUNCT
admet-553	268	8	and	and	CCONJ
admet-553	268	9	chi(iam	chi(iam	NOUN
admet-553	268	10	)	)	PUNCT
admet-553	268	11	values	value	NOUN
admet-553	268	12	under	under	ADP
admet-553	268	13	analogous	analogous	ADJ
admet-553	268	14	conditions	condition	NOUN
admet-553	268	15	permits	permit	VERB
admet-553	268	16	their	their	PRON
admet-553	268	17	incorporation	incorporation	NOUN
admet-553	268	18	in	in	ADP
admet-553	268	19	to	to	ADP
admet-553	268	20	databases	database	NOUN
admet-553	268	21	which	which	PRON
admet-553	268	22	could	could	AUX
admet-553	268	23	then	then	ADV
admet-553	268	24	serve	serve	VERB
admet-553	268	25	as	as	ADP
admet-553	268	26	a	a	DET
admet-553	268	27	tool	tool	NOUN
admet-553	268	28	for	for	ADP
admet-553	268	29	classification	classification	NOUN
admet-553	268	30	purposes	purpose	NOUN
admet-553	268	31	,	,	PUNCT
admet-553	268	32	as	as	ADV
admet-553	268	33	well	well	ADV
admet-553	268	34	as	as	ADP
admet-553	268	35	to	to	PART
admet-553	268	36	expand	expand	VERB
admet-553	268	37	the	the	DET
admet-553	268	38	druglike	druglike	NOUN
admet-553	268	39	concept	concept	NOUN
admet-553	268	40	,	,	PUNCT
admet-553	268	41	by	by	ADP
admet-553	268	42	incorporating	incorporate	VERB
admet-553	268	43	limit	limit	NOUN
admet-553	268	44	values	value	NOUN
admet-553	268	45	or	or	CCONJ
admet-553	268	46	ranges	range	NOUN
admet-553	268	47	for	for	ADP
admet-553	268	48	iam	iam	PROPN
admet-553	268	49	chromatographic	chromatographic	ADJ
admet-553	268	50	indices	index	NOUN
admet-553	268	51	.	.	PUNCT
admet-553	269	1	f.	f.	PROPN
admet-553	269	2	tsopelas	tsopelas	PROPN
admet-553	269	3	,	,	PUNCT
admet-553	269	4	c.	c.	PROPN
admet-553	269	5	stergiopoulos	stergiopoulos	PROPN
admet-553	269	6	,	,	PUNCT
admet-553	269	7	a.	a.	NOUN
admet-553	269	8	tsantili	tsantili	NOUN
admet-553	269	9	-	-	PUNCT
admet-553	269	10	kakoulidou	kakoulidou	NOUN
admet-553	269	11	admet	admet	PROPN
admet-553	269	12	&	&	CCONJ
admet-553	269	13	dmpk	dmpk	PROPN
admet-553	269	14	6(3	6(3	PROPN
admet-553	269	15	)	)	PUNCT
admet-553	269	16	(	(	PUNCT
admet-553	269	17	2018	2018	NUM
admet-553	269	18	)	)	PUNCT
admet-553	269	19	225	225	NUM
admet-553	269	20	-	-	SYM
admet-553	269	21	241	241	NUM
admet-553	269	22	236	236	NUM
admet-553	269	23	acknowledgements	acknowledgement	NOUN
admet-553	269	24	:	:	PUNCT
admet-553	269	25	under	under	ADP
admet-553	269	26	the	the	DET
admet-553	269	27	‘	'	PUNCT
admet-553	269	28	‘	'	PUNCT
admet-553	269	29	special	special	ADJ
admet-553	269	30	grant	grant	NOUN
admet-553	269	31	and	and	CCONJ
admet-553	269	32	support	support	NOUN
admet-553	269	33	program	program	NOUN
admet-553	269	34	for	for	ADP
admet-553	269	35	scholars	scholar	NOUN
admet-553	269	36	’	’	PART
admet-553	269	37	association	association	NOUN
admet-553	269	38	members	member	NOUN
admet-553	269	39	”	"	PUNCT
admet-553	269	40	(	(	PUNCT
admet-553	269	41	grant	grant	VERB
admet-553	269	42	no	no	INTJ
admet-553	269	43	.	.	PUNCT
admet-553	270	1	r	r	NOUN
admet-553	270	2	zn	zn	NUM
admet-553	270	3	004	004	NUM
admet-553	270	4	-	-	PUNCT
admet-553	270	5	1/2017	1/2017	NUM
admet-553	270	6	-	-	PUNCT
admet-553	270	7	2018	2018	NUM
admet-553	270	8	)	)	PUNCT
admet-553	270	9	.	.	PUNCT
admet-553	271	1	references	reference	NOUN
admet-553	271	2	[	[	X
admet-553	271	3	1	1	NUM
admet-553	271	4	]	]	PUNCT
admet-553	271	5	k.	k.	PROPN
admet-553	271	6	valko	valko	PROPN
admet-553	271	7	.	.	PUNCT
admet-553	272	1	application	application	NOUN
admet-553	272	2	of	of	ADP
admet-553	272	3	highperformance	highperformance	NOUN
admet-553	272	4	liquid	liquid	ADJ
admet-553	272	5	chromatography	chromatography	NOUN
admet-553	272	6	based	base	VERB
admet-553	272	7	measurements	measurement	NOUN
admet-553	272	8	of	of	ADP
admet-553	272	9	lipophilicity	lipophilicity	NOUN
admet-553	272	10	to	to	PART
admet-553	272	11	model	model	VERB
admet-553	272	12	biological	biological	ADJ
admet-553	272	13	distribution	distribution	NOUN
admet-553	272	14	.	.	PUNCT
admet-553	273	1	journal	journal	NOUN
admet-553	273	2	of	of	ADP
admet-553	273	3	chromatography	chromatography	NOUN
admet-553	273	4	a	a	DET
admet-553	273	5	1037	1037	NUM
admet-553	273	6	(	(	PUNCT
admet-553	273	7	2004	2004	NUM
admet-553	273	8	)	)	PUNCT
admet-553	273	9	299	299	NUM
admet-553	273	10	-	-	SYM
admet-553	273	11	310	310	NUM
admet-553	273	12	.	.	PUNCT
admet-553	274	1	[	[	X
admet-553	274	2	2	2	NUM
admet-553	274	3	]	]	PUNCT
admet-553	274	4	k.	k.	PROPN
admet-553	274	5	valko	valko	PROPN
admet-553	274	6	.	.	PUNCT
admet-553	275	1	physicochemical	physicochemical	ADJ
admet-553	275	2	and	and	CCONJ
admet-553	275	3	biomimetic	biomimetic	ADJ
admet-553	275	4	properties	property	NOUN
admet-553	275	5	in	in	ADP
admet-553	275	6	drug	drug	NOUN
admet-553	275	7	discovery	discovery	NOUN
admet-553	275	8	:	:	PUNCT
admet-553	275	9	chromatographic	chromatographic	ADJ
admet-553	275	10	techniques	technique	NOUN
admet-553	275	11	for	for	ADP
admet-553	275	12	lead	lead	ADJ
admet-553	275	13	optimization	optimization	NOUN
admet-553	275	14	.	.	PUNCT
admet-553	276	1	wiley	wiley	PROPN
admet-553	276	2	,	,	PUNCT
admet-553	276	3	hoboken	hoboken	PROPN
admet-553	276	4	,	,	PUNCT
admet-553	276	5	nj	nj	PROPN
admet-553	276	6	,	,	PUNCT
admet-553	276	7	2014	2014	NUM
admet-553	276	8	.	.	PUNCT
admet-553	277	1	[	[	X
admet-553	277	2	3	3	X
admet-553	277	3	]	]	X
admet-553	277	4	r.	r.	PROPN
admet-553	277	5	kaliszan	kaliszan	PROPN
admet-553	277	6	.	.	PUNCT
admet-553	278	1	chromatography	chromatography	NOUN
admet-553	278	2	and	and	CCONJ
admet-553	278	3	capillary	capillary	ADJ
admet-553	278	4	electrophoresis	electrophoresis	NOUN
admet-553	278	5	in	in	ADP
admet-553	278	6	modeling	model	VERB
admet-553	278	7	the	the	DET
admet-553	278	8	basic	basic	ADJ
admet-553	278	9	process	process	NOUN
admet-553	278	10	of	of	ADP
admet-553	278	11	drug	drug	NOUN
admet-553	278	12	action	action	NOUN
admet-553	278	13	.	.	PUNCT
admet-553	279	1	tractrends	tractrend	NOUN
admet-553	279	2	in	in	ADP
admet-553	279	3	analytical	analytical	ADJ
admet-553	279	4	chemistry	chemistry	NOUN
admet-553	279	5	18	18	NUM
admet-553	279	6	(	(	PUNCT
admet-553	279	7	1999	1999	NUM
admet-553	279	8	)	)	PUNCT
admet-553	279	9	400	400	NUM
admet-553	279	10	-	-	SYM
admet-553	279	11	410	410	NUM
admet-553	279	12	.	.	PUNCT
admet-553	280	1	[	[	X
admet-553	280	2	4	4	X
admet-553	280	3	]	]	X
admet-553	280	4	j.g	j.g	PROPN
admet-553	280	5	.	.	PROPN
admet-553	280	6	dorsey	dorsey	PROPN
admet-553	280	7	,	,	PUNCT
admet-553	280	8	m.g	m.g	PROPN
admet-553	280	9	.	.	PROPN
admet-553	280	10	khaledi	khaledi	PROPN
admet-553	280	11	.	.	PUNCT
admet-553	281	1	hydrophobicity	hydrophobicity	NOUN
admet-553	281	2	estimations	estimation	NOUN
admet-553	281	3	by	by	ADP
admet-553	281	4	reversed	reverse	VERB
admet-553	281	5	-	-	PUNCT
admet-553	281	6	phase	phase	NOUN
admet-553	281	7	liquid	liquid	ADJ
admet-553	281	8	chromatography	chromatography	NOUN
admet-553	281	9	.	.	PUNCT
admet-553	282	1	implications	implication	NOUN
admet-553	282	2	for	for	ADP
admet-553	282	3	biological	biological	ADJ
admet-553	282	4	partitioning	partitioning	NOUN
admet-553	282	5	processes	process	NOUN
admet-553	282	6	.	.	PUNCT
admet-553	283	1	journal	journal	PROPN
admet-553	283	2	of	of	ADP
admet-553	283	3	chromatography	chromatography	NOUN
admet-553	283	4	a	a	DET
admet-553	283	5	656	656	NUM
admet-553	283	6	(	(	PUNCT
admet-553	283	7	1993	1993	NUM
admet-553	283	8	)	)	PUNCT
admet-553	283	9	485	485	NUM
admet-553	283	10	-	-	SYM
admet-553	283	11	499	499	NUM
admet-553	283	12	.	.	PUNCT
admet-553	284	1	[	[	X
admet-553	284	2	5	5	NUM
admet-553	284	3	]	]	PUNCT
admet-553	284	4	a.	a.	NOUN
admet-553	284	5	leo	leo	PROPN
admet-553	284	6	,	,	PUNCT
admet-553	284	7	c.	c.	PROPN
admet-553	284	8	hansch	hansch	PROPN
admet-553	284	9	,	,	PUNCT
admet-553	284	10	d.	d.	PROPN
admet-553	284	11	elkins	elkins	PROPN
admet-553	284	12	.	.	PUNCT
admet-553	285	1	partition	partition	NOUN
admet-553	285	2	coefficients	coefficient	NOUN
admet-553	285	3	and	and	CCONJ
admet-553	285	4	their	their	PRON
admet-553	285	5	uses	use	NOUN
admet-553	285	6	.	.	PUNCT
admet-553	286	1	chemical	chemical	ADJ
admet-553	286	2	reviews	review	NOUN
admet-553	286	3	71	71	NUM
admet-553	286	4	(	(	PUNCT
admet-553	286	5	1971	1971	NUM
admet-553	286	6	)	)	PUNCT
admet-553	286	7	525616	525616	NUM
admet-553	286	8	.	.	PUNCT
admet-553	287	1	[	[	X
admet-553	287	2	6	6	NUM
admet-553	287	3	]	]	PUNCT
admet-553	287	4	m.	m.	NOUN
admet-553	287	5	chrysanthakopoulos	chrysanthakopoulo	NOUN
admet-553	287	6	,	,	PUNCT
admet-553	287	7	f.	f.	PROPN
admet-553	287	8	tsopelas	tsopelas	PROPN
admet-553	287	9	,	,	PUNCT
admet-553	287	10	a.	a.	PROPN
admet-553	287	11	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	287	12	.	.	PUNCT
admet-553	288	1	biomimetic	biomimetic	ADJ
admet-553	288	2	chromatography	chromatography	NOUN
admet-553	288	3	,	,	PUNCT
admet-553	288	4	a	a	DET
admet-553	288	5	useful	useful	ADJ
admet-553	288	6	tool	tool	NOUN
admet-553	288	7	in	in	ADP
admet-553	288	8	the	the	DET
admet-553	288	9	drug	drug	NOUN
admet-553	288	10	discovery	discovery	NOUN
admet-553	288	11	process	process	NOUN
admet-553	288	12	.	.	PUNCT
admet-553	289	1	in	in	ADP
admet-553	289	2	:	:	PUNCT
admet-553	289	3	e.	e.	PROPN
admet-553	289	4	grunshka	grunshka	PROPN
admet-553	289	5	,	,	PUNCT
admet-553	289	6	n.	n.	PROPN
admet-553	289	7	grinberg	grinberg	PROPN
admet-553	289	8	(	(	PUNCT
admet-553	289	9	eds	eds	PROPN
admet-553	289	10	.	.	PUNCT
admet-553	289	11	)	)	PUNCT
admet-553	289	12	.	.	PUNCT
admet-553	290	1	advances	advance	NOUN
admet-553	290	2	in	in	ADP
admet-553	290	3	chromatography	chromatography	NOUN
admet-553	290	4	,	,	PUNCT
admet-553	290	5	vol	vol	NOUN
admet-553	290	6	.	.	PROPN
admet-553	291	1	51	51	NUM
admet-553	291	2	(	(	PUNCT
admet-553	291	3	2014	2014	NUM
admet-553	291	4	)	)	PUNCT
admet-553	291	5	,	,	PUNCT
admet-553	292	1	pp	pp	PROPN
admet-553	292	2	.	.	PUNCT
admet-553	293	1	91	91	NUM
admet-553	293	2	-	-	SYM
admet-553	293	3	125	125	NUM
admet-553	293	4	.	.	PUNCT
admet-553	294	1	new	new	PROPN
admet-553	294	2	york	york	PROPN
admet-553	294	3	,	,	PUNCT
admet-553	294	4	crc	crc	NOUN
admet-553	294	5	press	press	NOUN
admet-553	294	6	.	.	PUNCT
admet-553	295	1	[	[	X
admet-553	295	2	7	7	X
admet-553	295	3	]	]	X
admet-553	295	4	f.	f.	PROPN
admet-553	295	5	tsopelas	tsopelas	PROPN
admet-553	295	6	,	,	PUNCT
admet-553	295	7	t.	t.	PROPN
admet-553	295	8	vallianatou	vallianatou	PROPN
admet-553	295	9	,	,	PUNCT
admet-553	295	10	a.	a.	NOUN
admet-553	295	11	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	295	12	.	.	PUNCT
admet-553	296	1	advances	advance	NOUN
admet-553	296	2	in	in	ADP
admet-553	296	3	immobilized	immobilized	ADJ
admet-553	296	4	artificial	artificial	ADJ
admet-553	296	5	membrane	membrane	NOUN
admet-553	296	6	(	(	PUNCT
admet-553	296	7	iam	iam	PROPN
admet-553	296	8	)	)	PUNCT
admet-553	296	9	chromatography	chromatography	NOUN
admet-553	296	10	for	for	ADP
admet-553	296	11	novel	novel	ADJ
admet-553	296	12	drug	drug	NOUN
admet-553	296	13	discovery	discovery	NOUN
admet-553	296	14	.	.	PUNCT
admet-553	297	1	expert	expert	ADJ
admet-553	297	2	opinion	opinion	NOUN
admet-553	297	3	on	on	ADP
admet-553	297	4	drug	drug	NOUN
admet-553	297	5	discovery	discovery	NOUN
admet-553	297	6	11	11	NUM
admet-553	297	7	(	(	PUNCT
admet-553	297	8	2016	2016	NUM
admet-553	297	9	)	)	PUNCT
admet-553	297	10	473488	473488	NUM
admet-553	297	11	.	.	PUNCT
admet-553	298	1	[	[	X
admet-553	298	2	8	8	NUM
admet-553	298	3	]	]	X
admet-553	298	4	f.	f.	PROPN
admet-553	298	5	tsopelas	tsopelas	PROPN
admet-553	298	6	,	,	PUNCT
admet-553	298	7	c.	c.	PROPN
admet-553	298	8	giaginis	giaginis	PROPN
admet-553	298	9	,	,	PUNCT
admet-553	298	10	a.	a.	NOUN
admet-553	298	11	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	298	12	.	.	PUNCT
admet-553	299	1	lipophilicity	lipophilicity	NOUN
admet-553	299	2	and	and	CCONJ
admet-553	299	3	biomimetic	biomimetic	ADJ
admet-553	299	4	properties	property	NOUN
admet-553	299	5	to	to	PART
admet-553	299	6	support	support	VERB
admet-553	299	7	drug	drug	NOUN
admet-553	299	8	discovery	discovery	NOUN
admet-553	299	9	.	.	PUNCT
admet-553	300	1	expert	expert	ADJ
admet-553	300	2	opinion	opinion	NOUN
admet-553	300	3	in	in	ADP
admet-553	300	4	drug	drug	NOUN
admet-553	300	5	discovery	discovery	NOUN
admet-553	300	6	12	12	NUM
admet-553	300	7	(	(	PUNCT
admet-553	300	8	2017	2017	NUM
admet-553	300	9	)	)	PUNCT
admet-553	300	10	885	885	NUM
admet-553	300	11	-	-	SYM
admet-553	300	12	896	896	NUM
admet-553	300	13	.	.	PUNCT
admet-553	301	1	[	[	X
admet-553	301	2	9	9	NUM
admet-553	301	3	]	]	PUNCT
admet-553	301	4	m.	m.	NOUN
admet-553	301	5	salary	salary	NOUN
admet-553	301	6	,	,	PUNCT
admet-553	301	7	m.	m.	NOUN
admet-553	301	8	hadjmohammadi	hadjmohammadi	NOUN
admet-553	301	9	.	.	PUNCT
admet-553	302	1	human	human	ADJ
admet-553	302	2	serum	serum	PROPN
admet-553	302	3	albuminmimetic	albuminmimetic	PROPN
admet-553	302	4	chromatography	chromatography	NOUN
admet-553	302	5	based	base	VERB
admet-553	302	6	hexadecyltrimethylammonium	hexadecyltrimethylammonium	NOUN
admet-553	302	7	bromide	bromide	NOUN
admet-553	302	8	as	as	ADP
admet-553	302	9	a	a	DET
admet-553	302	10	novel	novel	ADJ
admet-553	302	11	direct	direct	ADJ
admet-553	302	12	probe	probe	NOUN
admet-553	302	13	for	for	ADP
admet-553	302	14	protein	protein	NOUN
admet-553	302	15	binding	bind	VERB
admet-553	302	16	of	of	ADP
admet-553	302	17	acidic	acidic	ADJ
admet-553	302	18	drugs	drug	NOUN
admet-553	302	19	.	.	PUNCT
admet-553	303	1	journal	journal	NOUN
admet-553	303	2	of	of	ADP
admet-553	303	3	pharmaceutical	pharmaceutical	NOUN
admet-553	303	4	and	and	CCONJ
admet-553	303	5	biomedical	biomedical	ADJ
admet-553	303	6	analysis	analysis	NOUN
admet-553	303	7	114	114	NUM
admet-553	303	8	(	(	PUNCT
admet-553	303	9	2015	2015	NUM
admet-553	303	10	)	)	PUNCT
admet-553	303	11	1	1	NUM
admet-553	303	12	-	-	SYM
admet-553	303	13	7	7	NUM
admet-553	303	14	.	.	PUNCT
admet-553	304	1	[	[	X
admet-553	304	2	10	10	NUM
admet-553	304	3	]	]	X
admet-553	304	4	g.	g.	PROPN
admet-553	304	5	russo	russo	PROPN
admet-553	304	6	,	,	PUNCT
admet-553	304	7	l.	l.	PROPN
admet-553	304	8	grumetto	grumetto	PROPN
admet-553	304	9	,	,	PUNCT
admet-553	304	10	r.	r.	PROPN
admet-553	304	11	szucs	szucs	PROPN
admet-553	304	12	,	,	PUNCT
admet-553	304	13	f.	f.	PROPN
admet-553	304	14	barbato	barbato	PROPN
admet-553	304	15	,	,	PUNCT
admet-553	304	16	f.	f.	PROPN
admet-553	304	17	lynen	lynen	PROPN
admet-553	304	18	.	.	PUNCT
admet-553	305	1	determination	determination	NOUN
admet-553	305	2	of	of	ADP
admet-553	305	3	in	in	ADP
admet-553	305	4	vitro	vitro	X
admet-553	305	5	and	and	CCONJ
admet-553	305	6	in	in	ADP
admet-553	305	7	silico	silico	NOUN
admet-553	305	8	indexes	index	NOUN
admet-553	305	9	for	for	ADP
admet-553	305	10	the	the	DET
admet-553	305	11	modeling	modeling	NOUN
admet-553	305	12	of	of	ADP
admet-553	305	13	blood	blood	NOUN
admet-553	305	14	-	-	PUNCT
admet-553	305	15	brain	brain	NOUN
admet-553	305	16	barrier	barrier	NOUN
admet-553	305	17	partitioning	partitioning	NOUN
admet-553	305	18	of	of	ADP
admet-553	305	19	drugs	drug	NOUN
admet-553	305	20	via	via	ADP
admet-553	305	21	micellar	micellar	NOUN
admet-553	305	22	and	and	CCONJ
admet-553	305	23	immobilized	immobilize	VERB
admet-553	305	24	artificial	artificial	ADJ
admet-553	305	25	membrane	membrane	NOUN
admet-553	305	26	liquid	liquid	ADJ
admet-553	305	27	chromatography	chromatography	NOUN
admet-553	305	28	.	.	PUNCT
admet-553	306	1	journal	journal	PROPN
admet-553	306	2	of	of	ADP
admet-553	306	3	medicinal	medicinal	ADJ
admet-553	306	4	chemistry	chemistry	NOUN
admet-553	306	5	60	60	NUM
admet-553	306	6	(	(	PUNCT
admet-553	306	7	2017	2017	NUM
admet-553	306	8	)	)	PUNCT
admet-553	306	9	3739	3739	NUM
admet-553	306	10	-	-	SYM
admet-553	306	11	3754	3754	NUM
admet-553	306	12	.	.	PUNCT
admet-553	307	1	[	[	X
admet-553	307	2	11	11	NUM
admet-553	307	3	]	]	PUNCT
admet-553	307	4	k.	k.	PROPN
admet-553	307	5	valko	valko	PROPN
admet-553	307	6	.	.	PUNCT
admet-553	308	1	lipophilicity	lipophilicity	PROPN
admet-553	308	2	and	and	CCONJ
admet-553	308	3	biomimetic	biomimetic	ADJ
admet-553	308	4	properties	property	NOUN
admet-553	308	5	measured	measure	VERB
admet-553	308	6	by	by	ADP
admet-553	308	7	hplc	hplc	NOUN
admet-553	308	8	to	to	PART
admet-553	308	9	support	support	VERB
admet-553	308	10	drug	drug	NOUN
admet-553	308	11	discovery	discovery	NOUN
admet-553	308	12	.	.	PUNCT
admet-553	309	1	journal	journal	PROPN
admet-553	309	2	of	of	ADP
admet-553	309	3	pharmaceutical	pharmaceutical	NOUN
admet-553	309	4	and	and	CCONJ
admet-553	309	5	biomedical	biomedical	ADJ
admet-553	309	6	analysis	analysis	NOUN
admet-553	309	7	130	130	NUM
admet-553	309	8	(	(	PUNCT
admet-553	309	9	2016	2016	NUM
admet-553	309	10	)	)	PUNCT
admet-553	309	11	35	35	NUM
admet-553	309	12	-	-	SYM
admet-553	309	13	54	54	NUM
admet-553	309	14	.	.	PUNCT
admet-553	310	1	[	[	X
admet-553	310	2	12	12	NUM
admet-553	310	3	]	]	X
admet-553	310	4	c.j	c.j	PROPN
admet-553	310	5	.	.	PROPN
admet-553	310	6	van	van	PROPN
admet-553	310	7	leeuwen	leeuwen	PROPN
admet-553	310	8	,	,	PUNCT
admet-553	310	9	j.l.m	j.l.m	ADV
admet-553	310	10	.	.	PUNCT
admet-553	310	11	hermens	hermen	NOUN
admet-553	310	12	,	,	PUNCT
admet-553	310	13	risk	risk	NOUN
admet-553	310	14	assessment	assessment	NOUN
admet-553	310	15	of	of	ADP
admet-553	310	16	chemicals	chemical	NOUN
admet-553	310	17	.	.	PUNCT
admet-553	311	1	an	an	DET
admet-553	311	2	introduction	introduction	NOUN
admet-553	311	3	.	.	PUNCT
admet-553	312	1	kluwer	kluwer	PROPN
admet-553	312	2	academic	academic	PROPN
admet-553	312	3	,	,	PUNCT
admet-553	312	4	dordrecht	dordrecht	PROPN
admet-553	312	5	,	,	PUNCT
admet-553	312	6	1995	1995	NUM
admet-553	312	7	.	.	PUNCT
admet-553	313	1	[	[	X
admet-553	313	2	13	13	NUM
admet-553	313	3	]	]	PUNCT
admet-553	313	4	v.	v.	ADP
admet-553	313	5	pliska	pliska	PROPN
admet-553	313	6	,	,	PUNCT
admet-553	313	7	b.	b.	PROPN
admet-553	313	8	testa	testa	PROPN
admet-553	313	9	,	,	PUNCT
admet-553	313	10	h.	h.	PROPN
admet-553	313	11	van	van	PROPN
admet-553	313	12	de	de	PROPN
admet-553	313	13	waterbeemd	waterbeemd	PROPN
admet-553	313	14	(	(	PUNCT
admet-553	313	15	eds	ed	NOUN
admet-553	313	16	.	.	PUNCT
admet-553	313	17	)	)	PUNCT
admet-553	313	18	,	,	PUNCT
admet-553	313	19	lipophilicity	lipophilicity	NOUN
admet-553	313	20	in	in	ADP
admet-553	313	21	drug	drug	NOUN
admet-553	313	22	action	action	NOUN
admet-553	313	23	and	and	CCONJ
admet-553	313	24	toxicology	toxicology	NOUN
admet-553	313	25	,	,	PUNCT
admet-553	313	26	vch	vch	PROPN
admet-553	313	27	,	,	PUNCT
admet-553	313	28	weinheim	weinheim	PROPN
admet-553	313	29	,	,	PUNCT
admet-553	313	30	1996	1996	NUM
admet-553	313	31	.	.	PUNCT
admet-553	314	1	[	[	X
admet-553	314	2	14	14	NUM
admet-553	314	3	]	]	PUNCT
admet-553	314	4	regies	regie	NOUN
admet-553	314	5	technologies	technology	NOUN
admet-553	314	6	,	,	PUNCT
admet-553	314	7	inc	inc	PROPN
admet-553	314	8	,	,	PUNCT
admet-553	314	9	2016	2016	NUM
admet-553	314	10	.	.	PUNCT
admet-553	314	11	available	available	ADJ
admet-553	314	12	at	at	ADP
admet-553	314	13	http://www.registech.com/	http://www.registech.com/	NOUN
admet-553	314	14	(	(	PUNCT
admet-553	314	15	retrieved	retrieve	VERB
admet-553	314	16	at	at	ADP
admet-553	314	17	8	8	NUM
admet-553	314	18	-	-	SYM
admet-553	314	19	5	5	NUM
admet-553	314	20	-	-	PUNCT
admet-553	314	21	2018	2018	NUM
admet-553	314	22	)	)	PUNCT
admet-553	314	23	.	.	PUNCT
admet-553	315	1	[	[	X
admet-553	315	2	15	15	NUM
admet-553	315	3	]	]	X
admet-553	315	4	f.	f.	PROPN
admet-553	315	5	tsopelas	tsopelas	PROPN
admet-553	315	6	,	,	PUNCT
admet-553	315	7	a.	a.	NOUN
admet-553	315	8	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	315	9	,	,	PUNCT
admet-553	315	10	m.	m.	PROPN
admet-553	315	11	ochsenkühnpetropoulou	ochsenkühnpetropoulou	PROPN
admet-553	315	12	.	.	PUNCT
admet-553	316	1	biomimetic	biomimetic	ADJ
admet-553	316	2	chromatographic	chromatographic	ADJ
admet-553	316	3	analysis	analysis	NOUN
admet-553	316	4	of	of	ADP
admet-553	316	5	selenium	selenium	NOUN
admet-553	316	6	species	specie	NOUN
admet-553	316	7	:	:	PUNCT
admet-553	316	8	application	application	NOUN
admet-553	316	9	for	for	ADP
admet-553	316	10	the	the	DET
admet-553	316	11	estimation	estimation	NOUN
admet-553	316	12	of	of	ADP
admet-553	316	13	their	their	PRON
admet-553	316	14	pharmacokinetic	pharmacokinetic	ADJ
admet-553	316	15	properties	property	NOUN
admet-553	316	16	.	.	PUNCT
admet-553	317	1	analytical	analytical	ADJ
admet-553	317	2	and	and	CCONJ
admet-553	317	3	bioanalytical	bioanalytical	ADJ
admet-553	317	4	chemistry	chemistry	NOUN
admet-553	317	5	397	397	NUM
admet-553	317	6	(	(	PUNCT
admet-553	317	7	2010	2010	NUM
admet-553	317	8	)	)	PUNCT
admet-553	317	9	2171	2171	NUM
admet-553	317	10	-	-	SYM
admet-553	317	11	2180	2180	NUM
admet-553	317	12	.	.	PUNCT
admet-553	318	1	[	[	X
admet-553	318	2	16	16	NUM
admet-553	318	3	]	]	X
admet-553	318	4	l.	l.	PROPN
admet-553	318	5	grumetto	grumetto	PROPN
admet-553	318	6	,	,	PUNCT
admet-553	318	7	c.	c.	PROPN
admet-553	318	8	carpentiero	carpentiero	PROPN
admet-553	318	9	,	,	PUNCT
admet-553	318	10	p.	p.	NOUN
admet-553	318	11	di	di	NOUN
admet-553	318	12	vaio	vaio	PROPN
admet-553	318	13	,	,	PUNCT
admet-553	318	14	f.	f.	PROPN
admet-553	318	15	frecentese	frecentese	PROPN
admet-553	318	16	,	,	PUNCT
admet-553	318	17	f.	f.	PROPN
admet-553	318	18	barbato	barbato	PROPN
admet-553	318	19	.	.	PUNCT
admet-553	319	1	lipophilic	lipophilic	ADJ
admet-553	319	2	and	and	CCONJ
admet-553	319	3	polar	polar	ADJ
admet-553	319	4	interaction	interaction	NOUN
admet-553	319	5	forces	force	NOUN
admet-553	319	6	between	between	ADP
admet-553	319	7	acidic	acidic	ADJ
admet-553	319	8	drugs	drug	NOUN
admet-553	319	9	and	and	CCONJ
admet-553	319	10	membrane	membrane	NOUN
admet-553	319	11	phospholipids	phospholipid	NOUN
admet-553	319	12	encoded	encode	VERB
admet-553	319	13	in	in	ADP
admet-553	319	14	iamhplc	iamhplc	NOUN
admet-553	319	15	indices	index	NOUN
admet-553	319	16	:	:	PUNCT
admet-553	319	17	their	their	PRON
admet-553	319	18	role	role	NOUN
admet-553	319	19	in	in	ADP
admet-553	319	20	membrane	membrane	NOUN
admet-553	319	21	partition	partition	NOUN
admet-553	319	22	and	and	CCONJ
admet-553	319	23	relationships	relationship	NOUN
admet-553	319	24	with	with	ADP
admet-553	319	25	bbb	bbb	PROPN
admet-553	319	26	permeation	permeation	NOUN
admet-553	319	27	data	datum	NOUN
admet-553	319	28	.	.	PUNCT
admet-553	320	1	journal	journal	PROPN
admet-553	320	2	of	of	ADP
admet-553	320	3	pharmaceutical	pharmaceutical	NOUN
admet-553	320	4	and	and	CCONJ
admet-553	320	5	biomedical	biomedical	ADJ
admet-553	320	6	analysis	analysis	NOUN
admet-553	320	7	75	75	NUM
admet-553	320	8	(	(	PUNCT
admet-553	320	9	2013	2013	NUM
admet-553	320	10	)	)	PUNCT
admet-553	320	11	165	165	NUM
admet-553	320	12	-	-	SYM
admet-553	320	13	172	172	NUM
admet-553	320	14	.	.	PUNCT
admet-553	321	1	admet	admet	PROPN
admet-553	321	2	&	&	CCONJ
admet-553	321	3	dmpk	dmpk	PROPN
admet-553	321	4	6(3	6(3	PROPN
admet-553	321	5	)	)	PUNCT
admet-553	321	6	(	(	PUNCT
admet-553	321	7	2018	2018	NUM
admet-553	321	8	)	)	PUNCT
admet-553	321	9	225	225	NUM
admet-553	321	10	-	-	SYM
admet-553	321	11	241	241	NUM
admet-553	321	12	iam	iam	PROPN
admet-553	321	13	chromatography	chromatography	NOUN
admet-553	321	14	in	in	ADP
admet-553	321	15	medicinal	medicinal	ADJ
admet-553	321	16	chemistry	chemistry	NOUN
admet-553	321	17	and	and	CCONJ
admet-553	321	18	environment	environment	NOUN
admet-553	321	19	doi	doi	PROPN
admet-553	321	20	:	:	PUNCT
admet-553	321	21	10.5599	10.5599	NUM
admet-553	321	22	/	/	SYM
admet-553	321	23	admet.553	admet.553	NOUN
admet-553	321	24	237	237	NUM
admet-553	321	25	[	[	X
admet-553	321	26	17	17	NUM
admet-553	321	27	]	]	X
admet-553	321	28	f.	f.	PROPN
admet-553	321	29	tsopelas	tsopelas	PROPN
admet-553	321	30	,	,	PUNCT
admet-553	321	31	t.	t.	PROPN
admet-553	321	32	vallianatou	vallianatou	PROPN
admet-553	321	33	,	,	PUNCT
admet-553	321	34	a.	a.	NOUN
admet-553	321	35	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	321	36	.	.	PUNCT
admet-553	322	1	the	the	DET
admet-553	322	2	potential	potential	NOUN
admet-553	322	3	of	of	ADP
admet-553	322	4	immobilized	immobilized	ADJ
admet-553	322	5	artificial	artificial	ADJ
admet-553	322	6	membrane	membrane	NOUN
admet-553	322	7	chromatography	chromatography	NOUN
admet-553	322	8	to	to	PART
admet-553	322	9	predict	predict	VERB
admet-553	322	10	human	human	ADJ
admet-553	322	11	oral	oral	ADJ
admet-553	322	12	absorption	absorption	NOUN
admet-553	322	13	.	.	PUNCT
admet-553	323	1	european	european	PROPN
admet-553	323	2	journal	journal	PROPN
admet-553	323	3	of	of	ADP
admet-553	323	4	pharmaceutical	pharmaceutical	PROPN
admet-553	323	5	sciences	science	NOUN
admet-553	323	6	81	81	NUM
admet-553	323	7	(	(	PUNCT
admet-553	323	8	2016	2016	NUM
admet-553	323	9	)	)	PUNCT
admet-553	323	10	82	82	NUM
admet-553	323	11	-	-	SYM
admet-553	323	12	93	93	NUM
admet-553	323	13	.	.	PUNCT
admet-553	324	1	[	[	X
admet-553	324	2	18	18	NUM
admet-553	324	3	]	]	X
admet-553	324	4	l.	l.	PROPN
admet-553	324	5	grumetto	grumetto	PROPN
admet-553	324	6	,	,	PUNCT
admet-553	324	7	g.	g.	PROPN
admet-553	324	8	russo	russo	PROPN
admet-553	324	9	,	,	PUNCT
admet-553	324	10	f.	f.	PROPN
admet-553	324	11	barbato	barbato	PROPN
admet-553	324	12	.	.	PUNCT
admet-553	325	1	polar	polar	ADJ
admet-553	325	2	interactions	interaction	NOUN
admet-553	325	3	drug/	drug/	NUM
admet-553	325	4	phospholipids	phospholipid	NOUN
admet-553	325	5	and	and	CCONJ
admet-553	325	6	comparison	comparison	NOUN
admet-553	325	7	of	of	ADP
admet-553	325	8	their	their	PRON
admet-553	325	9	effectiveness	effectiveness	NOUN
admet-553	325	10	in	in	ADP
admet-553	325	11	predicting	predict	VERB
admet-553	325	12	drug	drug	NOUN
admet-553	325	13	human	human	ADJ
admet-553	325	14	intestinal	intestinal	ADJ
admet-553	325	15	absorption	absorption	NOUN
admet-553	325	16	.	.	PUNCT
admet-553	326	1	international	international	ADJ
admet-553	326	2	journal	journal	NOUN
admet-553	326	3	of	of	ADP
admet-553	326	4	pharmacy	pharmacy	NOUN
admet-553	326	5	500	500	NUM
admet-553	326	6	(	(	PUNCT
admet-553	326	7	2016	2016	NUM
admet-553	326	8	)	)	PUNCT
admet-553	326	9	275	275	NUM
admet-553	326	10	-	-	SYM
admet-553	326	11	290	290	NUM
admet-553	326	12	.	.	PUNCT
admet-553	327	1	[	[	X
admet-553	327	2	19	19	NUM
admet-553	327	3	]	]	X
admet-553	327	4	l.	l.	PROPN
admet-553	327	5	grumetto	grumetto	PROPN
admet-553	327	6	,	,	PUNCT
admet-553	327	7	g.	g.	PROPN
admet-553	327	8	russo	russo	PROPN
admet-553	327	9	,	,	PUNCT
admet-553	327	10	f.	f.	PROPN
admet-553	327	11	barbato	barbato	PROPN
admet-553	327	12	.	.	PUNCT
admet-553	328	1	immobilized	immobilize	VERB
admet-553	328	2	artificial	artificial	ADJ
admet-553	328	3	membrane	membrane	NOUN
admet-553	328	4	hplc	hplc	NOUN
admet-553	328	5	derived	derive	VERB
admet-553	328	6	parameters	parameter	NOUN
admet-553	328	7	vs	vs	ADP
admet-553	328	8	pampabbb	pampabbb	ADJ
admet-553	328	9	data	datum	NOUN
admet-553	328	10	in	in	ADP
admet-553	328	11	estimating	estimate	VERB
admet-553	328	12	in	in	ADP
admet-553	328	13	situ	situ	ADJ
admet-553	328	14	measured	measure	VERB
admet-553	328	15	blood	blood	NOUN
admet-553	328	16	-	-	PUNCT
admet-553	328	17	brain	brain	NOUN
admet-553	328	18	barrier	barrier	NOUN
admet-553	328	19	permeation	permeation	NOUN
admet-553	328	20	of	of	ADP
admet-553	328	21	drugs	drug	NOUN
admet-553	328	22	.	.	PUNCT
admet-553	329	1	molecular	molecular	ADJ
admet-553	329	2	pharmaceutics	pharmaceutic	NOUN
admet-553	329	3	13	13	NUM
admet-553	329	4	(	(	PUNCT
admet-553	329	5	2016	2016	NUM
admet-553	329	6	)	)	PUNCT
admet-553	329	7	2808	2808	NUM
admet-553	329	8	-	-	SYM
admet-553	329	9	2816	2816	NUM
admet-553	329	10	.	.	PUNCT
admet-553	330	1	[	[	X
admet-553	330	2	20	20	NUM
admet-553	330	3	]	]	X
admet-553	330	4	f.	f.	PROPN
admet-553	330	5	tsopelas	tsopelas	PROPN
admet-553	330	6	,	,	PUNCT
admet-553	330	7	m.	m.	NOUN
admet-553	330	8	tsagkrasouli	tsagkrasouli	PROPN
admet-553	330	9	,	,	PUNCT
admet-553	330	10	p.	p.	NOUN
admet-553	330	11	poursanidis	poursanidis	NOUN
admet-553	330	12	,	,	PUNCT
admet-553	330	13	m.	m.	NOUN
admet-553	330	14	pitsaki	pitsaki	PROPN
admet-553	330	15	,	,	PUNCT
admet-553	330	16	g.	g.	PROPN
admet-553	330	17	vasios	vasios	PROPN
admet-553	330	18	,	,	PUNCT
admet-553	330	19	p.	p.	NOUN
admet-553	330	20	danias	danias	PROPN
admet-553	330	21	,	,	PUNCT
admet-553	330	22	i.	i.	PROPN
admet-553	330	23	panderi	panderi	PROPN
admet-553	330	24	,	,	PUNCT
admet-553	330	25	a.	a.	NOUN
admet-553	330	26	tsantili	tsantili	PROPN
admet-553	330	27	kakoulidou	kakoulidou	PROPN
admet-553	330	28	.	.	PUNCT
admet-553	331	1	retention	retention	NOUN
admet-553	331	2	behavior	behavior	NOUN
admet-553	331	3	of	of	ADP
admet-553	331	4	flavonoids	flavonoid	NOUN
admet-553	331	5	on	on	ADP
admet-553	331	6	immobilized	immobilized	ADJ
admet-553	331	7	artificial	artificial	ADJ
admet-553	331	8	membrane	membrane	NOUN
admet-553	331	9	chromatography	chromatography	NOUN
admet-553	331	10	and	and	CCONJ
admet-553	331	11	correlation	correlation	NOUN
admet-553	331	12	with	with	ADP
admet-553	331	13	cell	cell	NOUN
admet-553	331	14	-	-	PUNCT
admet-553	331	15	based	base	VERB
admet-553	331	16	permeability	permeability	NOUN
admet-553	331	17	.	.	PUNCT
admet-553	332	1	biomedical	biomedical	ADJ
admet-553	332	2	chromatography	chromatography	NOUN
admet-553	332	3	32	32	NUM
admet-553	332	4	(	(	PUNCT
admet-553	332	5	2018	2018	NUM
admet-553	332	6	)	)	PUNCT
admet-553	332	7	e4108	e4108	NOUN
admet-553	332	8	.	.	PUNCT
admet-553	333	1	[	[	X
admet-553	333	2	21	21	NUM
admet-553	333	3	]	]	X
admet-553	333	4	f.	f.	PROPN
admet-553	333	5	tsopelas	tsopelas	PROPN
admet-553	333	6	,	,	PUNCT
admet-553	333	7	c.	c.	PROPN
admet-553	333	8	stergiopoulos	stergiopoulos	PROPN
admet-553	333	9	,	,	PUNCT
admet-553	333	10	l.a	l.a	PROPN
admet-553	333	11	.	.	PROPN
admet-553	333	12	tsakanika	tsakanika	PROPN
admet-553	333	13	,	,	PUNCT
admet-553	333	14	m.	m.	PROPN
admet-553	333	15	ochsenkühnpetropoulou	ochsenkühnpetropoulou	PROPN
admet-553	333	16	,	,	PUNCT
admet-553	333	17	a.	a.	PROPN
admet-553	333	18	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	333	19	.	.	PUNCT
admet-553	334	1	the	the	DET
admet-553	334	2	use	use	NOUN
admet-553	334	3	of	of	ADP
admet-553	334	4	immobilized	immobilized	ADJ
admet-553	334	5	artificial	artificial	ADJ
admet-553	334	6	membrane	membrane	NOUN
admet-553	334	7	chromatography	chromatography	NOUN
admet-553	334	8	to	to	PART
admet-553	334	9	predict	predict	VERB
admet-553	334	10	bioconcentration	bioconcentration	NOUN
admet-553	334	11	of	of	ADP
admet-553	334	12	pharmaceutical	pharmaceutical	NOUN
admet-553	334	13	compounds	compound	NOUN
admet-553	334	14	.	.	PUNCT
admet-553	335	1	ecotoxicology	ecotoxicology	NOUN
admet-553	335	2	and	and	CCONJ
admet-553	335	3	environmental	environmental	ADJ
admet-553	335	4	safety	safety	NOUN
admet-553	335	5	139	139	NUM
admet-553	335	6	(	(	PUNCT
admet-553	335	7	2017	2017	NUM
admet-553	335	8	)	)	PUNCT
admet-553	335	9	150	150	NUM
admet-553	335	10	-	-	SYM
admet-553	335	11	157	157	NUM
admet-553	335	12	.	.	PUNCT
admet-553	336	1	[	[	X
admet-553	336	2	22	22	NUM
admet-553	336	3	]	]	PUNCT
admet-553	336	4	h.	h.	PROPN
admet-553	336	5	liu	liu	PROPN
admet-553	336	6	,	,	PUNCT
admet-553	336	7	s.	s.	PROPN
admet-553	336	8	ong	ong	PROPN
admet-553	336	9	,	,	PUNCT
admet-553	336	10	l.	l.	PROPN
admet-553	336	11	glunz	glunz	PROPN
admet-553	336	12	,	,	PUNCT
admet-553	336	13	c.	c.	PROPN
admet-553	336	14	pidgeon	pidgeon	PROPN
admet-553	336	15	.	.	PUNCT
admet-553	337	1	predicting	predict	VERB
admet-553	337	2	drugmembrane	drugmembrane	ADJ
admet-553	337	3	interactions	interaction	NOUN
admet-553	337	4	by	by	ADP
admet-553	337	5	hplc	hplc	NOUN
admet-553	337	6	:	:	PUNCT
admet-553	337	7	structural	structural	ADJ
admet-553	337	8	requirements	requirement	NOUN
admet-553	337	9	of	of	ADP
admet-553	337	10	chromatographic	chromatographic	ADJ
admet-553	337	11	surfaces	surface	NOUN
admet-553	337	12	.	.	PUNCT
admet-553	338	1	analytical	analytical	ADJ
admet-553	338	2	chemistry	chemistry	NOUN
admet-553	338	3	67	67	NUM
admet-553	338	4	(	(	PUNCT
admet-553	338	5	1995	1995	NUM
admet-553	338	6	)	)	PUNCT
admet-553	338	7	355	355	NUM
admet-553	338	8	-	-	SYM
admet-553	338	9	3557	3557	NUM
admet-553	338	10	.	.	PUNCT
admet-553	339	1	[	[	X
admet-553	339	2	23	23	NUM
admet-553	339	3	]	]	X
admet-553	339	4	f.	f.	PROPN
admet-553	339	5	barbato	barbato	PROPN
admet-553	339	6	,	,	PUNCT
admet-553	339	7	g.	g.	PROPN
admet-553	339	8	di	di	PROPN
admet-553	339	9	martino	martino	PROPN
admet-553	339	10	,	,	PUNCT
admet-553	339	11	l.	l.	PROPN
admet-553	339	12	grumetto	grumetto	PROPN
admet-553	339	13	,	,	PUNCT
admet-553	339	14	m.i	m.i	PROPN
admet-553	339	15	.	.	PROPN
admet-553	339	16	la	la	PROPN
admet-553	339	17	rotonda	rotonda	PROPN
admet-553	339	18	.	.	PUNCT
admet-553	340	1	can	can	AUX
admet-553	340	2	protonated	protonate	VERB
admet-553	340	3	β	β	NOUN
admet-553	340	4	-	-	NOUN
admet-553	340	5	blockers	blocker	NOUN
admet-553	340	6	interact	interact	VERB
admet-553	340	7	with	with	ADP
admet-553	340	8	biomembranes	biomembrane	NOUN
admet-553	340	9	stronger	strong	ADJ
admet-553	340	10	than	than	ADP
admet-553	340	11	neutral	neutral	ADJ
admet-553	340	12	isolipophilic	isolipophilic	ADJ
admet-553	340	13	compounds	compound	NOUN
admet-553	340	14	?	?	PUNCT
admet-553	341	1	a	a	DET
admet-553	341	2	chromatographic	chromatographic	ADJ
admet-553	341	3	study	study	NOUN
admet-553	341	4	on	on	ADP
admet-553	341	5	three	three	NUM
admet-553	341	6	different	different	ADJ
admet-553	341	7	phospholipid	phospholipid	NOUN
admet-553	341	8	stationary	stationary	ADJ
admet-553	341	9	phases	phase	NOUN
admet-553	341	10	(	(	PUNCT
admet-553	341	11	iamhplc	iamhplc	NOUN
admet-553	341	12	)	)	PUNCT
admet-553	341	13	.	.	PUNCT
admet-553	342	1	european	european	PROPN
admet-553	342	2	journal	journal	PROPN
admet-553	342	3	of	of	ADP
admet-553	342	4	pharmaceutical	pharmaceutical	PROPN
admet-553	342	5	sciences	science	NOUN
admet-553	342	6	25	25	NUM
admet-553	342	7	(	(	PUNCT
admet-553	342	8	2005	2005	NUM
admet-553	342	9	)	)	PUNCT
admet-553	342	10	379	379	NUM
admet-553	342	11	-	-	SYM
admet-553	342	12	386	386	NUM
admet-553	342	13	.	.	PUNCT
admet-553	343	1	[	[	X
admet-553	343	2	24	24	NUM
admet-553	343	3	]	]	PUNCT
admet-553	343	4	c.	c.	NOUN
admet-553	343	5	giaginis	giaginis	PROPN
admet-553	343	6	,	,	PUNCT
admet-553	343	7	a.	a.	NOUN
admet-553	343	8	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	343	9	.	.	PUNCT
admet-553	344	1	alternative	alternative	ADJ
admet-553	344	2	measures	measure	NOUN
admet-553	344	3	of	of	ADP
admet-553	344	4	lipophilicity	lipophilicity	NOUN
admet-553	344	5	:	:	PUNCT
admet-553	344	6	from	from	ADP
admet-553	344	7	octanol	octanol	NOUN
admet-553	344	8	-	-	PUNCT
admet-553	344	9	water	water	NOUN
admet-553	344	10	partitioning	partitioning	NOUN
admet-553	344	11	to	to	ADP
admet-553	344	12	iam	iam	PROPN
admet-553	344	13	retention	retention	NOUN
admet-553	344	14	.	.	PUNCT
admet-553	345	1	journal	journal	NOUN
admet-553	345	2	of	of	ADP
admet-553	345	3	pharmaceutical	pharmaceutical	PROPN
admet-553	345	4	sciences	science	NOUN
admet-553	345	5	97	97	NUM
admet-553	345	6	(	(	PUNCT
admet-553	345	7	2008	2008	NUM
admet-553	345	8	)	)	PUNCT
admet-553	345	9	2984	2984	NUM
admet-553	345	10	-	-	SYM
admet-553	345	11	3004	3004	NUM
admet-553	345	12	.	.	PUNCT
admet-553	346	1	[	[	X
admet-553	346	2	25	25	NUM
admet-553	346	3	]	]	X
admet-553	346	4	l.	l.	PROPN
admet-553	346	5	grumetto	grumetto	PROPN
admet-553	346	6	,	,	PUNCT
admet-553	346	7	g.	g.	PROPN
admet-553	346	8	russo	russo	PROPN
admet-553	346	9	,	,	PUNCT
admet-553	346	10	f.	f.	PROPN
admet-553	346	11	barbato	barbato	PROPN
admet-553	346	12	.	.	PUNCT
admet-553	347	1	indexes	index	NOUN
admet-553	347	2	of	of	ADP
admet-553	347	3	polar	polar	ADJ
admet-553	347	4	interactions	interaction	NOUN
admet-553	347	5	between	between	ADP
admet-553	347	6	ionizable	ionizable	ADJ
admet-553	347	7	drugs	drug	NOUN
admet-553	347	8	and	and	CCONJ
admet-553	347	9	membrane	membrane	NOUN
admet-553	347	10	phospholipids	phospholipid	NOUN
admet-553	347	11	measured	measure	VERB
admet-553	347	12	by	by	ADP
admet-553	347	13	iamhplc	iamhplc	PROPN
admet-553	347	14	:	:	PUNCT
admet-553	347	15	their	their	PRON
admet-553	347	16	relationships	relationship	NOUN
admet-553	347	17	with	with	ADP
admet-553	347	18	data	datum	NOUN
admet-553	347	19	of	of	ADP
admet-553	347	20	blood	blood	NOUN
admet-553	347	21	-	-	PUNCT
admet-553	347	22	brain	brain	NOUN
admet-553	347	23	barrier	barrier	NOUN
admet-553	347	24	passage	passage	NOUN
admet-553	347	25	.	.	PUNCT
admet-553	348	1	european	european	ADJ
admet-553	348	2	journal	journal	PROPN
admet-553	348	3	of	of	ADP
admet-553	348	4	pharmaceutical	pharmaceutical	PROPN
admet-553	348	5	sciences	science	NOUN
admet-553	348	6	65	65	NUM
admet-553	348	7	(	(	PUNCT
admet-553	348	8	2014	2014	NUM
admet-553	348	9	)	)	PUNCT
admet-553	348	10	139	139	NUM
admet-553	348	11	-	-	SYM
admet-553	348	12	146	146	NUM
admet-553	348	13	.	.	PUNCT
admet-553	349	1	[	[	X
admet-553	349	2	26	26	NUM
admet-553	349	3	]	]	X
admet-553	349	4	f.	f.	PROPN
admet-553	349	5	tsopelas	tsopelas	PROPN
admet-553	349	6	,	,	PUNCT
admet-553	349	7	n.	n.	PROPN
admet-553	349	8	malaki	malaki	PROPN
admet-553	349	9	,	,	PUNCT
admet-553	349	10	t.	t.	NOUN
admet-553	349	11	vallianatou	vallianatou	NOUN
admet-553	349	12	,	,	PUNCT
admet-553	349	13	m.	m.	NOUN
admet-553	349	14	chrysanthakopoulos	chrysanthakopoulo	NOUN
admet-553	349	15	,	,	PUNCT
admet-553	349	16	d.	d.	PROPN
admet-553	349	17	vrakas	vrakas	PROPN
admet-553	349	18	,	,	PUNCT
admet-553	349	19	m.	m.	PROPN
admet-553	349	20	ochsenkühn	ochsenkühn	PROPN
admet-553	349	21	petropoulou	petropoulou	PROPN
admet-553	349	22	,	,	PUNCT
admet-553	349	23	a.	a.	NOUN
admet-553	349	24	tsantili	tsantili	NOUN
admet-553	349	25	-	-	PUNCT
admet-553	349	26	kakoulidou	kakoulidou	NOUN
admet-553	349	27	.	.	PUNCT
admet-553	349	28	insight	insight	NOUN
admet-553	349	29	into	into	ADP
admet-553	349	30	the	the	DET
admet-553	349	31	retention	retention	NOUN
admet-553	349	32	mechanism	mechanism	NOUN
admet-553	349	33	on	on	ADP
admet-553	349	34	immobilized	immobilized	ADJ
admet-553	349	35	artificial	artificial	ADJ
admet-553	349	36	membrane	membrane	NOUN
admet-553	349	37	chromatography	chromatography	NOUN
admet-553	349	38	using	use	VERB
admet-553	349	39	two	two	NUM
admet-553	349	40	stationary	stationary	ADJ
admet-553	349	41	phases	phase	NOUN
admet-553	349	42	.	.	PUNCT
admet-553	350	1	journal	journal	NOUN
admet-553	350	2	of	of	ADP
admet-553	350	3	chromatography	chromatography	NOUN
admet-553	350	4	a	a	DET
admet-553	350	5	1396	1396	NUM
admet-553	350	6	(	(	PUNCT
admet-553	350	7	2015	2015	NUM
admet-553	350	8	)	)	PUNCT
admet-553	350	9	25	25	NUM
admet-553	350	10	-	-	SYM
admet-553	350	11	33	33	NUM
admet-553	350	12	.	.	PUNCT
admet-553	351	1	[	[	X
admet-553	351	2	27	27	NUM
admet-553	351	3	]	]	X
admet-553	351	4	g.	g.	PROPN
admet-553	351	5	russo	russo	PROPN
admet-553	351	6	,	,	PUNCT
admet-553	351	7	l.	l.	PROPN
admet-553	351	8	grumetto	grumetto	PROPN
admet-553	351	9	,	,	PUNCT
admet-553	351	10	f.	f.	PROPN
admet-553	351	11	barbato	barbato	PROPN
admet-553	351	12	,	,	PUNCT
admet-553	351	13	g.	g.	PROPN
admet-553	351	14	vistoli	vistoli	PROPN
admet-553	351	15	,	,	PUNCT
admet-553	351	16	a.	a.	NOUN
admet-553	351	17	pedretti	pedretti	PROPN
admet-553	351	18	.	.	PUNCT
admet-553	352	1	prediction	prediction	NOUN
admet-553	352	2	and	and	CCONJ
admet-553	352	3	mechanism	mechanism	NOUN
admet-553	352	4	elucidation	elucidation	NOUN
admet-553	352	5	of	of	ADP
admet-553	352	6	analyte	analyte	NOUN
admet-553	352	7	retention	retention	NOUN
admet-553	352	8	on	on	ADP
admet-553	352	9	phospholipid	phospholipid	NOUN
admet-553	352	10	stationary	stationary	ADJ
admet-553	352	11	phases	phase	NOUN
admet-553	352	12	(	(	PUNCT
admet-553	352	13	iamhplc	iamhplc	NOUN
admet-553	352	14	)	)	PUNCT
admet-553	352	15	by	by	ADP
admet-553	352	16	in	in	ADP
admet-553	352	17	silico	silico	NOUN
admet-553	352	18	calculated	calculate	VERB
admet-553	352	19	physicochemical	physicochemical	ADJ
admet-553	352	20	descriptors	descriptor	NOUN
admet-553	352	21	.	.	PUNCT
admet-553	353	1	european	european	ADJ
admet-553	353	2	journal	journal	PROPN
admet-553	353	3	of	of	ADP
admet-553	353	4	pharmaceutical	pharmaceutical	PROPN
admet-553	353	5	sciences	science	NOUN
admet-553	353	6	99	99	NUM
admet-553	353	7	(	(	PUNCT
admet-553	353	8	2017	2017	NUM
admet-553	353	9	)	)	PUNCT
admet-553	353	10	173	173	NUM
admet-553	353	11	-	-	SYM
admet-553	353	12	184	184	NUM
admet-553	353	13	.	.	PUNCT
admet-553	354	1	[	[	X
admet-553	354	2	28	28	NUM
admet-553	354	3	]	]	X
admet-553	354	4	f.	f.	PROPN
admet-553	354	5	tsopelas	tsopelas	PROPN
admet-553	354	6	,	,	PUNCT
admet-553	354	7	m.	m.	PROPN
admet-553	354	8	ochsenkühnpetropoulou	ochsenkühnpetropoulou	PROPN
admet-553	354	9	,	,	PUNCT
admet-553	354	10	a.	a.	NOUN
admet-553	354	11	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	354	12	.	.	PUNCT
admet-553	355	1	void	void	ADJ
admet-553	355	2	volume	volume	NOUN
admet-553	355	3	markers	marker	NOUN
admet-553	355	4	in	in	ADP
admet-553	355	5	reversed	reverse	VERB
admet-553	355	6	phase	phase	NOUN
admet-553	355	7	and	and	CCONJ
admet-553	355	8	biomimetic	biomimetic	ADJ
admet-553	355	9	liquid	liquid	ADJ
admet-553	355	10	chromatography	chromatography	NOUN
admet-553	355	11	.	.	PUNCT
admet-553	356	1	journal	journal	PROPN
admet-553	356	2	of	of	ADP
admet-553	356	3	chromatography	chromatography	NOUN
admet-553	356	4	a	a	DET
admet-553	356	5	1217	1217	NUM
admet-553	356	6	(	(	PUNCT
admet-553	356	7	2010	2010	NUM
admet-553	356	8	)	)	PUNCT
admet-553	356	9	2847	2847	NUM
admet-553	356	10	-	-	SYM
admet-553	356	11	2854	2854	NUM
admet-553	356	12	.	.	PUNCT
admet-553	357	1	[	[	X
admet-553	357	2	29	29	NUM
admet-553	357	3	]	]	PUNCT
admet-553	357	4	s.	s.	PROPN
admet-553	357	5	ong	ong	PROPN
admet-553	357	6	,	,	PUNCT
admet-553	357	7	c.	c.	PROPN
admet-553	357	8	pidgeon	pidgeon	PROPN
admet-553	357	9	.	.	PUNCT
admet-553	358	1	thermodynamics	thermodynamic	NOUN
admet-553	358	2	of	of	ADP
admet-553	358	3	solute	solute	NOUN
admet-553	358	4	partitioning	partition	VERB
admet-553	358	5	into	into	ADP
admet-553	358	6	immobilized	immobilized	ADJ
admet-553	358	7	artificial	artificial	ADJ
admet-553	358	8	membranes	membrane	NOUN
admet-553	358	9	.	.	PUNCT
admet-553	359	1	analytical	analytical	ADJ
admet-553	359	2	chemistry	chemistry	NOUN
admet-553	359	3	67	67	NUM
admet-553	359	4	(	(	PUNCT
admet-553	359	5	1995	1995	NUM
admet-553	359	6	)	)	PUNCT
admet-553	359	7	2119	2119	NUM
admet-553	359	8	-	-	SYM
admet-553	359	9	2128	2128	NUM
admet-553	359	10	.	.	PUNCT
admet-553	360	1	[	[	X
admet-553	360	2	30	30	NUM
admet-553	360	3	]	]	X
admet-553	360	4	e.	e.	PROPN
admet-553	360	5	lazaro	lazaro	PROPN
admet-553	360	6	,	,	PUNCT
admet-553	360	7	c.	c.	PROPN
admet-553	360	8	rafols	rafols	PROPN
admet-553	360	9	,	,	PUNCT
admet-553	360	10	m.h	m.h	PROPN
admet-553	360	11	.	.	PROPN
admet-553	360	12	abraham	abraham	PROPN
admet-553	360	13	,	,	PUNCT
admet-553	360	14	m.	m.	NOUN
admet-553	360	15	roses	rose	NOUN
admet-553	360	16	.	.	PUNCT
admet-553	361	1	chromatographic	chromatographic	ADJ
admet-553	361	2	estimation	estimation	NOUN
admet-553	361	3	of	of	ADP
admet-553	361	4	drug	drug	NOUN
admet-553	361	5	disposition	disposition	NOUN
admet-553	361	6	properties	property	NOUN
admet-553	361	7	by	by	ADP
admet-553	361	8	means	mean	NOUN
admet-553	361	9	of	of	ADP
admet-553	361	10	immobilized	immobilized	ADJ
admet-553	361	11	artificial	artificial	ADJ
admet-553	361	12	membranes	membrane	NOUN
admet-553	361	13	(	(	PUNCT
admet-553	361	14	iam	iam	PROPN
admet-553	361	15	)	)	PUNCT
admet-553	361	16	and	and	CCONJ
admet-553	361	17	c18	c18	NOUN
admet-553	361	18	columns	column	NOUN
admet-553	361	19	.	.	PUNCT
admet-553	362	1	journal	journal	PROPN
admet-553	362	2	of	of	ADP
admet-553	362	3	medicinal	medicinal	ADJ
admet-553	362	4	chemistry	chemistry	NOUN
admet-553	362	5	49	49	NUM
admet-553	362	6	(	(	PUNCT
admet-553	362	7	2006	2006	NUM
admet-553	362	8	)	)	PUNCT
admet-553	362	9	4861	4861	NUM
admet-553	362	10	-	-	SYM
admet-553	362	11	4870	4870	NUM
admet-553	362	12	.	.	PUNCT
admet-553	363	1	[	[	X
admet-553	363	2	31	31	NUM
admet-553	363	3	]	]	X
admet-553	363	4	d.	d.	PROPN
admet-553	363	5	vrakas	vrakas	PROPN
admet-553	363	6	,	,	PUNCT
admet-553	363	7	c.	c.	PROPN
admet-553	363	8	giaginis	giaginis	PROPN
admet-553	363	9	,	,	PUNCT
admet-553	363	10	a.	a.	NOUN
admet-553	363	11	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	363	12	.	.	PUNCT
admet-553	364	1	the	the	DET
admet-553	364	2	different	different	ADJ
admet-553	364	3	behaviour	behaviour	NOUN
admet-553	364	4	of	of	ADP
admet-553	364	5	structurally	structurally	ADV
admet-553	364	6	diverse	diverse	ADJ
admet-553	364	7	basic	basic	ADJ
admet-553	364	8	and	and	CCONJ
admet-553	364	9	neutral	neutral	ADJ
admet-553	364	10	drugs	drug	NOUN
admet-553	364	11	in	in	ADP
admet-553	364	12	the	the	DET
admet-553	364	13	immobilized	immobilized	ADJ
admet-553	364	14	artificial	artificial	ADJ
admet-553	364	15	membrane	membrane	NOUN
admet-553	364	16	and	and	CCONJ
admet-553	364	17	reversed	reversed	ADJ
admet-553	364	18	-	-	PUNCT
admet-553	364	19	phase	phase	NOUN
admet-553	364	20	high	high	ADJ
admet-553	364	21	-	-	PUNCT
admet-553	364	22	performance	performance	NOUN
admet-553	364	23	liquid	liquid	ADJ
admet-553	364	24	chromatography	chromatography	NOUN
admet-553	364	25	:	:	PUNCT
admet-553	364	26	comparison	comparison	NOUN
admet-553	364	27	with	with	ADP
admet-553	364	28	octanol	octanol	NOUN
admet-553	364	29	-	-	PUNCT
admet-553	364	30	water	water	NOUN
admet-553	364	31	partitioning	partitioning	NOUN
admet-553	364	32	.	.	PUNCT
admet-553	365	1	journal	journal	PROPN
admet-553	365	2	of	of	ADP
admet-553	365	3	chromatography	chromatography	NOUN
admet-553	365	4	a	a	DET
admet-553	365	5	1116	1116	NUM
admet-553	365	6	(	(	PUNCT
admet-553	365	7	2006	2006	NUM
admet-553	365	8	)	)	PUNCT
admet-553	365	9	158	158	NUM
admet-553	365	10	-	-	SYM
admet-553	365	11	164	164	NUM
admet-553	365	12	.	.	PUNCT
admet-553	366	1	[	[	X
admet-553	366	2	32	32	NUM
admet-553	366	3	]	]	PUNCT
admet-553	366	4	j.	j.	PROPN
admet-553	366	5	kotecha	kotecha	PROPN
admet-553	366	6	,	,	PUNCT
admet-553	366	7	s.	s.	PROPN
admet-553	366	8	shah	shah	PROPN
admet-553	366	9	,	,	PUNCT
admet-553	366	10	i.	i.	PROPN
admet-553	366	11	rathod	rathod	PROPN
admet-553	366	12	,	,	PUNCT
admet-553	366	13	g.	g.	PROPN
admet-553	366	14	subbaiah	subbaiah	PROPN
admet-553	366	15	.	.	PUNCT
admet-553	367	1	relationships	relationship	NOUN
admet-553	367	2	between	between	ADP
admet-553	367	3	immobilized	immobilized	ADJ
admet-553	367	4	artificial	artificial	ADJ
admet-553	367	5	membrane	membrane	NOUN
admet-553	367	6	chromatographic	chromatographic	ADJ
admet-553	367	7	retention	retention	NOUN
admet-553	367	8	and	and	CCONJ
admet-553	367	9	human	human	ADJ
admet-553	367	10	oral	oral	ADJ
admet-553	367	11	absorption	absorption	NOUN
admet-553	367	12	of	of	ADP
admet-553	367	13	structurally	structurally	ADV
admet-553	367	14	diverse	diverse	ADJ
admet-553	367	15	drugs	drug	NOUN
admet-553	367	16	.	.	PUNCT
admet-553	368	1	international	international	ADJ
admet-553	368	2	journal	journal	PROPN
admet-553	368	3	of	of	ADP
admet-553	368	4	pharmaceutics	pharmaceutic	NOUN
admet-553	368	5	333	333	NUM
admet-553	368	6	(	(	PUNCT
admet-553	368	7	2007	2007	NUM
admet-553	368	8	)	)	PUNCT
admet-553	368	9	127	127	NUM
admet-553	368	10	-	-	SYM
admet-553	368	11	135	135	NUM
admet-553	368	12	.	.	PUNCT
admet-553	369	1	[	[	X
admet-553	369	2	33	33	NUM
admet-553	369	3	]	]	PUNCT
admet-553	369	4	j.	j.	PROPN
admet-553	369	5	kotecha	kotecha	PROPN
admet-553	369	6	,	,	PUNCT
admet-553	369	7	s.	s.	PROPN
admet-553	369	8	shah	shah	PROPN
admet-553	369	9	,	,	PUNCT
admet-553	369	10	i.	i.	PROPN
admet-553	369	11	rathod	rathod	PROPN
admet-553	369	12	,	,	PUNCT
admet-553	369	13	g.	g.	PROPN
admet-553	369	14	subbaiah	subbaiah	PROPN
admet-553	369	15	.	.	PUNCT
admet-553	370	1	prediction	prediction	NOUN
admet-553	370	2	of	of	ADP
admet-553	370	3	oral	oral	ADJ
admet-553	370	4	absorption	absorption	NOUN
admet-553	370	5	in	in	ADP
admet-553	370	6	humans	human	NOUN
admet-553	370	7	by	by	ADP
admet-553	370	8	experimental	experimental	ADJ
admet-553	370	9	immobilized	immobilized	ADJ
admet-553	370	10	artificial	artificial	ADJ
admet-553	370	11	membrane	membrane	NOUN
admet-553	370	12	chromatography	chromatography	NOUN
admet-553	370	13	indices	index	NOUN
admet-553	370	14	and	and	CCONJ
admet-553	370	15	physicochemical	physicochemical	ADJ
admet-553	370	16	descriptors	descriptor	NOUN
admet-553	370	17	.	.	PUNCT
admet-553	371	1	international	international	ADJ
admet-553	371	2	journal	journal	PROPN
admet-553	371	3	of	of	ADP
admet-553	371	4	pharmaceutics	pharmaceutic	NOUN
admet-553	371	5	360	360	NUM
admet-553	371	6	(	(	PUNCT
admet-553	371	7	2008	2008	NUM
admet-553	371	8	)	)	PUNCT
admet-553	371	9	96	96	NUM
admet-553	371	10	-	-	SYM
admet-553	371	11	106	106	NUM
admet-553	371	12	.	.	PUNCT
admet-553	372	1	f.	f.	PROPN
admet-553	372	2	tsopelas	tsopelas	PROPN
admet-553	372	3	,	,	PUNCT
admet-553	372	4	c.	c.	PROPN
admet-553	372	5	stergiopoulos	stergiopoulos	PROPN
admet-553	372	6	,	,	PUNCT
admet-553	372	7	a.	a.	NOUN
admet-553	372	8	tsantili	tsantili	NOUN
admet-553	372	9	-	-	PUNCT
admet-553	372	10	kakoulidou	kakoulidou	NOUN
admet-553	372	11	admet	admet	PROPN
admet-553	372	12	&	&	CCONJ
admet-553	372	13	dmpk	dmpk	PROPN
admet-553	372	14	6(3	6(3	PROPN
admet-553	372	15	)	)	PUNCT
admet-553	372	16	(	(	PUNCT
admet-553	372	17	2018	2018	NUM
admet-553	372	18	)	)	PUNCT
admet-553	372	19	225	225	NUM
admet-553	372	20	-	-	SYM
admet-553	372	21	241	241	NUM
admet-553	372	22	238	238	NUM
admet-553	372	23	[	[	X
admet-553	372	24	34	34	NUM
admet-553	372	25	]	]	X
admet-553	372	26	d.	d.	PROPN
admet-553	372	27	vrakas	vrakas	PROPN
admet-553	372	28	,	,	PUNCT
admet-553	372	29	c.	c.	PROPN
admet-553	372	30	giaginis	giaginis	PROPN
admet-553	372	31	,	,	PUNCT
admet-553	372	32	a.	a.	NOUN
admet-553	372	33	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	372	34	.	.	PUNCT
admet-553	373	1	electrostatic	electrostatic	ADJ
admet-553	373	2	interactions	interaction	NOUN
admet-553	373	3	and	and	CCONJ
admet-553	373	4	ionization	ionization	NOUN
admet-553	373	5	effect	effect	NOUN
admet-553	373	6	in	in	ADP
admet-553	373	7	immobilized	immobilized	ADJ
admet-553	373	8	artificial	artificial	ADJ
admet-553	373	9	membrane	membrane	NOUN
admet-553	373	10	retention	retention	NOUN
admet-553	373	11	.	.	PUNCT
admet-553	374	1	a	a	DET
admet-553	374	2	comparative	comparative	ADJ
admet-553	374	3	study	study	NOUN
admet-553	374	4	with	with	ADP
admet-553	374	5	octanol	octanol	NOUN
admet-553	374	6	-	-	PUNCT
admet-553	374	7	water	water	NOUN
admet-553	374	8	partitioning	partitioning	NOUN
admet-553	374	9	.	.	PUNCT
admet-553	375	1	journal	journal	PROPN
admet-553	375	2	of	of	ADP
admet-553	375	3	chromatography	chromatography	NOUN
admet-553	375	4	a	a	PRON
admet-553	375	5	1187	1187	NUM
admet-553	375	6	(	(	PUNCT
admet-553	375	7	2008	2008	NUM
admet-553	375	8	)	)	PUNCT
admet-553	375	9	67	67	NUM
admet-553	375	10	-	-	SYM
admet-553	375	11	78	78	NUM
admet-553	375	12	.	.	PUNCT
admet-553	376	1	[	[	X
admet-553	376	2	35	35	NUM
admet-553	376	3	]	]	X
admet-553	376	4	f.	f.	PROPN
admet-553	376	5	tsopelas	tsopelas	PROPN
admet-553	376	6	,	,	PUNCT
admet-553	376	7	a.	a.	NOUN
admet-553	376	8	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	376	9	,	,	PUNCT
admet-553	376	10	m.	m.	PROPN
admet-553	376	11	ochsenkühnpetropoulou	ochsenkühnpetropoulou	PROPN
admet-553	376	12	.	.	PUNCT
admet-553	377	1	lipophilicity	lipophilicity	PROPN
admet-553	377	2	,	,	PUNCT
admet-553	377	3	biomimetic	biomimetic	ADJ
admet-553	377	4	retention	retention	NOUN
admet-553	377	5	profile	profile	NOUN
admet-553	377	6	and	and	CCONJ
admet-553	377	7	antioxidant	antioxidant	ADJ
admet-553	377	8	activity	activity	NOUN
admet-553	377	9	of	of	ADP
admet-553	377	10	selenium	selenium	NOUN
admet-553	377	11	species	specie	NOUN
admet-553	377	12	.	.	PUNCT
admet-553	378	1	microchemical	microchemical	ADJ
admet-553	378	2	journal	journal	NOUN
admet-553	378	3	110	110	NUM
admet-553	378	4	(	(	PUNCT
admet-553	378	5	2013	2013	NUM
admet-553	378	6	)	)	PUNCT
admet-553	378	7	711	711	NUM
admet-553	378	8	-	-	SYM
admet-553	378	9	718	718	NUM
admet-553	378	10	.	.	PUNCT
admet-553	379	1	[	[	X
admet-553	379	2	36	36	NUM
admet-553	379	3	]	]	X
admet-553	379	4	y.	y.	PROPN
admet-553	379	5	marcus	marcus	PROPN
admet-553	379	6	,	,	PUNCT
admet-553	379	7	y.	y.	PROPN
admet-553	379	8	migron	migron	PROPN
admet-553	379	9	.	.	PUNCT
admet-553	380	1	polarity	polarity	NOUN
admet-553	380	2	,	,	PUNCT
admet-553	380	3	hydrogen	hydrogen	NOUN
admet-553	380	4	bonding	bonding	NOUN
admet-553	380	5	,	,	PUNCT
admet-553	380	6	and	and	CCONJ
admet-553	380	7	structure	structure	NOUN
admet-553	380	8	of	of	ADP
admet-553	380	9	mixtures	mixture	NOUN
admet-553	380	10	of	of	ADP
admet-553	380	11	water	water	NOUN
admet-553	380	12	and	and	CCONJ
admet-553	380	13	cyanomethane	cyanomethane	NOUN
admet-553	380	14	.	.	PUNCT
admet-553	381	1	journal	journal	PROPN
admet-553	381	2	of	of	ADP
admet-553	381	3	physical	physical	ADJ
admet-553	381	4	chemistry	chemistry	NOUN
admet-553	381	5	95	95	NUM
admet-553	381	6	(	(	PUNCT
admet-553	381	7	1991	1991	NUM
admet-553	381	8	)	)	PUNCT
admet-553	381	9	400	400	NUM
admet-553	381	10	-	-	SYM
admet-553	381	11	406	406	NUM
admet-553	381	12	.	.	PUNCT
admet-553	382	1	[	[	X
admet-553	382	2	37	37	NUM
admet-553	382	3	]	]	PUNCT
admet-553	382	4	k.	k.	PROPN
admet-553	382	5	morse	morse	PROPN
admet-553	382	6	,	,	PUNCT
admet-553	382	7	c.	c.	PROPN
admet-553	382	8	pidgeon	pidgeon	PROPN
admet-553	382	9	.	.	PUNCT
admet-553	383	1	importance	importance	NOUN
admet-553	383	2	of	of	ADP
admet-553	383	3	mobile	mobile	ADJ
admet-553	383	4	phase	phase	NOUN
admet-553	383	5	in	in	ADP
admet-553	383	6	immobilized	immobilized	ADJ
admet-553	383	7	artificial	artificial	ADJ
admet-553	383	8	membrane	membrane	NOUN
admet-553	383	9	chromatography	chromatography	NOUN
admet-553	383	10	.	.	PUNCT
admet-553	384	1	in	in	ADP
admet-553	384	2	:	:	PUNCT
admet-553	384	3	b.	b.	PROPN
admet-553	384	4	testa	testa	PROPN
admet-553	384	5	,	,	PUNCT
admet-553	384	6	h.	h.	PROPN
admet-553	384	7	van	van	PROPN
admet-553	384	8	de	de	PROPN
admet-553	384	9	waterbeemd	waterbeemd	PROPN
admet-553	384	10	,	,	PUNCT
admet-553	384	11	g.	g.	PROPN
admet-553	384	12	folkers	folkers	PROPN
admet-553	384	13	,	,	PUNCT
admet-553	384	14	r.	r.	PROPN
admet-553	384	15	guy	guy	PROPN
admet-553	384	16	(	(	PUNCT
admet-553	384	17	eds	ed	NOUN
admet-553	384	18	.	.	PUNCT
admet-553	384	19	)	)	PUNCT
admet-553	384	20	,	,	PUNCT
admet-553	384	21	pharmacokinetic	pharmacokinetic	ADJ
admet-553	384	22	optimization	optimization	NOUN
admet-553	384	23	in	in	ADP
admet-553	384	24	drug	drug	NOUN
admet-553	384	25	research	research	NOUN
admet-553	384	26	,	,	PUNCT
admet-553	384	27	verlag	verlag	PROPN
admet-553	384	28	helvetica	helvetica	PROPN
admet-553	384	29	chimica	chimica	PROPN
admet-553	384	30	acta	acta	PROPN
admet-553	384	31	,	,	PUNCT
admet-553	384	32	zurich	zurich	PROPN
admet-553	384	33	and	and	CCONJ
admet-553	384	34	wileyvch	wileyvch	PROPN
admet-553	384	35	,	,	PUNCT
admet-553	384	36	weinheim	weinheim	NOUN
admet-553	384	37	,	,	PUNCT
admet-553	384	38	2001	2001	NUM
admet-553	384	39	,	,	PUNCT
admet-553	384	40	pp	pp	ADJ
admet-553	384	41	.	.	PUNCT
admet-553	384	42	351	351	NUM
admet-553	384	43	-	-	SYM
admet-553	384	44	381	381	NUM
admet-553	384	45	.	.	PUNCT
admet-553	385	1	[	[	X
admet-553	385	2	38	38	NUM
admet-553	385	3	]	]	PUNCT
admet-553	385	4	a.	a.	NOUN
admet-553	385	5	taillardatbertschinger	taillardatbertschinger	PROPN
admet-553	385	6	,	,	PUNCT
admet-553	385	7	p.a	p.a	PROPN
admet-553	385	8	.	.	PROPN
admet-553	385	9	carrupt	carrupt	PROPN
admet-553	385	10	,	,	PUNCT
admet-553	385	11	f.	f.	PROPN
admet-553	385	12	barbato	barbato	PROPN
admet-553	385	13	,	,	PUNCT
admet-553	385	14	b.	b.	PROPN
admet-553	385	15	testa	testa	PROPN
admet-553	385	16	.	.	PUNCT
admet-553	385	17	immobilized	immobilize	VERB
admet-553	385	18	artificial	artificial	ADJ
admet-553	385	19	membrane	membrane	NOUN
admet-553	385	20	hplc	hplc	NOUN
admet-553	385	21	in	in	ADP
admet-553	385	22	drug	drug	NOUN
admet-553	385	23	research	research	NOUN
admet-553	385	24	.	.	PUNCT
admet-553	386	1	journal	journal	NOUN
admet-553	386	2	of	of	ADP
admet-553	386	3	medicinal	medicinal	ADJ
admet-553	386	4	chemistry	chemistry	NOUN
admet-553	386	5	46	46	NUM
admet-553	386	6	(	(	PUNCT
admet-553	386	7	2003	2003	NUM
admet-553	386	8	)	)	PUNCT
admet-553	386	9	655	655	NUM
admet-553	386	10	-	-	SYM
admet-553	386	11	665	665	NUM
admet-553	386	12	.	.	PUNCT
admet-553	387	1	[	[	X
admet-553	387	2	39	39	NUM
admet-553	387	3	]	]	PUNCT
admet-553	387	4	k.	k.	PROPN
admet-553	387	5	valko	valko	PROPN
admet-553	387	6	,	,	PUNCT
admet-553	387	7	c.m	c.m	PROPN
admet-553	387	8	.	.	PROPN
admet-553	387	9	du	du	PROPN
admet-553	387	10	,	,	PUNCT
admet-553	387	11	c.d	c.d	PROPN
admet-553	387	12	.	.	PROPN
admet-553	387	13	bevan	bevan	PROPN
admet-553	387	14	,	,	PUNCT
admet-553	387	15	d.p	d.p	PROPN
admet-553	387	16	.	.	PROPN
admet-553	387	17	reynolds	reynolds	PROPN
admet-553	387	18	,	,	PUNCT
admet-553	387	19	m.h	m.h	PROPN
admet-553	387	20	.	.	PROPN
admet-553	387	21	abraham	abraham	PROPN
admet-553	387	22	.	.	PUNCT
admet-553	388	1	rapidgradient	rapidgradient	PROPN
admet-553	388	2	hplc	hplc	NOUN
admet-553	388	3	method	method	NOUN
admet-553	388	4	for	for	ADP
admet-553	388	5	measuring	measure	VERB
admet-553	388	6	drug	drug	NOUN
admet-553	388	7	interactions	interaction	NOUN
admet-553	388	8	with	with	ADP
admet-553	388	9	immobilized	immobilized	ADJ
admet-553	388	10	artificial	artificial	ADJ
admet-553	388	11	membrane	membrane	NOUN
admet-553	388	12	:	:	PUNCT
admet-553	388	13	comparison	comparison	NOUN
admet-553	388	14	with	with	ADP
admet-553	388	15	other	other	ADJ
admet-553	388	16	lipophilicity	lipophilicity	NOUN
admet-553	388	17	measures	measure	NOUN
admet-553	388	18	.	.	PUNCT
admet-553	389	1	journal	journal	NOUN
admet-553	389	2	of	of	ADP
admet-553	389	3	pharmaceutical	pharmaceutical	PROPN
admet-553	389	4	sciences	science	NOUN
admet-553	389	5	89	89	NUM
admet-553	389	6	(	(	PUNCT
admet-553	389	7	2000	2000	NUM
admet-553	389	8	)	)	PUNCT
admet-553	389	9	1085	1085	NUM
admet-553	389	10	-	-	SYM
admet-553	389	11	1096	1096	NUM
admet-553	389	12	.	.	PUNCT
admet-553	390	1	[	[	X
admet-553	390	2	40	40	NUM
admet-553	390	3	]	]	PUNCT
admet-553	390	4	f.	f.	PROPN
admet-553	390	5	hollosy	hollosy	PROPN
admet-553	390	6	,	,	PUNCT
admet-553	390	7	k.	k.	PROPN
admet-553	390	8	valko	valko	PROPN
admet-553	390	9	,	,	PUNCT
admet-553	390	10	a.	a.	PROPN
admet-553	390	11	hersey	hersey	PROPN
admet-553	390	12	,	,	PUNCT
admet-553	390	13	s.	s.	PROPN
admet-553	390	14	nunhuck	nunhuck	PROPN
admet-553	390	15	,	,	PUNCT
admet-553	390	16	g.	g.	PROPN
admet-553	390	17	keri	keri	PROPN
admet-553	390	18	,	,	PUNCT
admet-553	390	19	c.	c.	PROPN
admet-553	390	20	bevan	bevan	PROPN
admet-553	390	21	.	.	PUNCT
admet-553	391	1	estimation	estimation	NOUN
admet-553	391	2	of	of	ADP
admet-553	391	3	volume	volume	NOUN
admet-553	391	4	of	of	ADP
admet-553	391	5	distribution	distribution	NOUN
admet-553	391	6	in	in	ADP
admet-553	391	7	humans	human	NOUN
admet-553	391	8	from	from	ADP
admet-553	391	9	high	high	ADJ
admet-553	391	10	throughput	throughput	NOUN
admet-553	391	11	hplcbased	hplcbase	VERB
admet-553	391	12	measurements	measurement	NOUN
admet-553	391	13	of	of	ADP
admet-553	391	14	human	human	ADJ
admet-553	391	15	serum	serum	NOUN
admet-553	391	16	albumin	albumin	NOUN
admet-553	391	17	binding	bind	VERB
admet-553	391	18	and	and	CCONJ
admet-553	391	19	immobilized	immobilize	VERB
admet-553	391	20	artificial	artificial	ADJ
admet-553	391	21	membrane	membrane	NOUN
admet-553	391	22	partitioning	partitioning	NOUN
admet-553	391	23	.	.	PUNCT
admet-553	392	1	journal	journal	PROPN
admet-553	392	2	of	of	ADP
admet-553	392	3	medicinal	medicinal	ADJ
admet-553	392	4	chemistry	chemistry	NOUN
admet-553	392	5	49	49	NUM
admet-553	392	6	(	(	PUNCT
admet-553	392	7	2006	2006	NUM
admet-553	392	8	)	)	PUNCT
admet-553	392	9	6958	6958	NUM
admet-553	392	10	-	-	SYM
admet-553	392	11	6971	6971	NUM
admet-553	392	12	.	.	PUNCT
admet-553	393	1	[	[	X
admet-553	393	2	41	41	NUM
admet-553	393	3	]	]	PUNCT
admet-553	393	4	k.	k.	PROPN
admet-553	393	5	valko	valko	PROPN
admet-553	393	6	,	,	PUNCT
admet-553	393	7	s.	s.	PROPN
admet-553	393	8	teague	teague	PROPN
admet-553	393	9	,	,	PUNCT
admet-553	393	10	c.	c.	PROPN
admet-553	393	11	pidgeon	pidgeon	PROPN
admet-553	393	12	.	.	PUNCT
admet-553	394	1	in	in	ADP
admet-553	394	2	vitro	vitro	X
admet-553	394	3	membrane	membrane	NOUN
admet-553	394	4	binding	bind	VERB
admet-553	394	5	and	and	CCONJ
admet-553	394	6	protein	protein	NOUN
admet-553	394	7	binding	bind	VERB
admet-553	394	8	(	(	PUNCT
admet-553	394	9	iam	iam	PROPN
admet-553	394	10	mb	mb	PROPN
admet-553	394	11	/	/	SYM
admet-553	394	12	pb	pb	X
admet-553	394	13	technology	technology	NOUN
admet-553	394	14	)	)	PUNCT
admet-553	394	15	to	to	PART
admet-553	394	16	estimate	estimate	VERB
admet-553	394	17	in	in	ADP
admet-553	394	18	vivo	vivo	ADJ
admet-553	394	19	distribution	distribution	NOUN
admet-553	394	20	:	:	PUNCT
admet-553	394	21	applications	application	NOUN
admet-553	394	22	in	in	ADP
admet-553	394	23	early	early	ADJ
admet-553	394	24	drug	drug	NOUN
admet-553	394	25	discovery	discovery	NOUN
admet-553	394	26	.	.	PUNCT
admet-553	395	1	admet	admet	PROPN
admet-553	395	2	&	&	CCONJ
admet-553	395	3	dmpk	dmpk	PROPN
admet-553	395	4	5(1	5(1	NUM
admet-553	395	5	)	)	PUNCT
admet-553	395	6	(	(	PUNCT
admet-553	395	7	2017	2017	NUM
admet-553	395	8	)	)	PUNCT
admet-553	395	9	14	14	NUM
admet-553	395	10	-	-	SYM
admet-553	395	11	38	38	NUM
admet-553	395	12	.	.	PUNCT
admet-553	396	1	[	[	X
admet-553	396	2	42	42	NUM
admet-553	396	3	]	]	X
admet-553	396	4	g.p	g.p	PROPN
admet-553	396	5	.	.	PROPN
admet-553	396	6	van	van	PROPN
admet-553	396	7	balen	balen	PROPN
admet-553	396	8	,	,	PUNCT
admet-553	396	9	c.a.m	c.a.m	X
admet-553	396	10	.	.	PUNCT
admet-553	396	11	martinet	martinet	PROPN
admet-553	396	12	,	,	PUNCT
admet-553	396	13	g.	g.	PROPN
admet-553	396	14	caron	caron	PROPN
admet-553	396	15	,	,	PUNCT
admet-553	396	16	g.	g.	PROPN
admet-553	396	17	bouchard	bouchard	PROPN
admet-553	396	18	,	,	PUNCT
admet-553	396	19	m.	m.	NOUN
admet-553	396	20	reist	reist	PROPN
admet-553	396	21	,	,	PUNCT
admet-553	396	22	p.a	p.a	PROPN
admet-553	396	23	.	.	PROPN
admet-553	396	24	carrupt	carrupt	PROPN
admet-553	396	25	,	,	PUNCT
admet-553	396	26	r.	r.	PROPN
admet-553	396	27	fruttero	fruttero	PROPN
admet-553	396	28	,	,	PUNCT
admet-553	396	29	a.	a.	NOUN
admet-553	396	30	gasco	gasco	PROPN
admet-553	396	31	,	,	PUNCT
admet-553	396	32	b.	b.	PROPN
admet-553	396	33	testa	testa	PROPN
admet-553	396	34	.	.	PUNCT
admet-553	397	1	liposome/	liposome/	NUM
admet-553	397	2	water	water	NOUN
admet-553	397	3	lipophilicity	lipophilicity	NOUN
admet-553	397	4	:	:	PUNCT
admet-553	397	5	methods	method	NOUN
admet-553	397	6	,	,	PUNCT
admet-553	397	7	information	information	NOUN
admet-553	397	8	content	content	NOUN
admet-553	397	9	,	,	PUNCT
admet-553	397	10	and	and	CCONJ
admet-553	397	11	pharmaceutical	pharmaceutical	NOUN
admet-553	397	12	applications	application	NOUN
admet-553	397	13	.	.	PUNCT
admet-553	398	1	medicinal	medicinal	ADJ
admet-553	398	2	research	research	NOUN
admet-553	398	3	reviews	review	NOUN
admet-553	398	4	24	24	NUM
admet-553	398	5	(	(	PUNCT
admet-553	398	6	2004	2004	NUM
admet-553	398	7	)	)	PUNCT
admet-553	398	8	299	299	NUM
admet-553	398	9	-	-	SYM
admet-553	398	10	324	324	NUM
admet-553	398	11	.	.	PUNCT
admet-553	399	1	[	[	X
admet-553	399	2	43	43	NUM
admet-553	399	3	]	]	X
admet-553	399	4	j.	j.	PROPN
admet-553	399	5	li	li	PROPN
admet-553	399	6	,	,	PUNCT
admet-553	399	7	j.	j.	PROPN
admet-553	399	8	sun	sun	PROPN
admet-553	399	9	,	,	PUNCT
admet-553	399	10	z.	z.	PROPN
admet-553	399	11	he	he	PRON
admet-553	399	12	.	.	PUNCT
admet-553	400	1	quantitative	quantitative	ADJ
admet-553	400	2	structure	structure	NOUN
admet-553	400	3	-	-	PUNCT
admet-553	400	4	retention	retention	NOUN
admet-553	400	5	relationship	relationship	NOUN
admet-553	400	6	studies	study	NOUN
admet-553	400	7	using	use	VERB
admet-553	400	8	immobilized	immobilized	ADJ
admet-553	400	9	artificial	artificial	ADJ
admet-553	400	10	membrane	membrane	NOUN
admet-553	400	11	chromatography	chromatography	NOUN
admet-553	401	1	i	i	PRON
admet-553	401	2	:	:	PUNCT
admet-553	401	3	amended	amend	VERB
admet-553	401	4	linear	linear	PROPN
admet-553	401	5	solvation	solvation	NOUN
admet-553	401	6	energy	energy	NOUN
admet-553	401	7	relationships	relationship	NOUN
admet-553	401	8	with	with	ADP
admet-553	401	9	the	the	DET
admet-553	401	10	introduction	introduction	NOUN
admet-553	401	11	of	of	ADP
admet-553	401	12	a	a	DET
admet-553	401	13	molecular	molecular	ADJ
admet-553	401	14	electronic	electronic	ADJ
admet-553	401	15	factor	factor	NOUN
admet-553	401	16	.	.	PUNCT
admet-553	402	1	journal	journal	PROPN
admet-553	402	2	of	of	ADP
admet-553	402	3	chromatography	chromatography	NOUN
admet-553	402	4	a	a	DET
admet-553	402	5	1132	1132	NUM
admet-553	402	6	(	(	PUNCT
admet-553	402	7	2006	2006	NUM
admet-553	402	8	)	)	PUNCT
admet-553	402	9	174	174	NUM
admet-553	402	10	-	-	SYM
admet-553	402	11	182	182	NUM
admet-553	402	12	.	.	PUNCT
admet-553	403	1	[	[	X
admet-553	403	2	44	44	NUM
admet-553	403	3	]	]	X
admet-553	403	4	m.h	m.h	PROPN
admet-553	403	5	.	.	PROPN
admet-553	403	6	abraham	abraham	PROPN
admet-553	403	7	,	,	PUNCT
admet-553	403	8	w.e	w.e	PROPN
admet-553	403	9	.	.	PROPN
admet-553	403	10	acree	acree	PROPN
admet-553	403	11	,	,	PUNCT
admet-553	403	12	a.	a.	PROPN
admet-553	403	13	fahr	fahr	PROPN
admet-553	403	14	,	,	PUNCT
admet-553	403	15	x.	x.	PROPN
admet-553	403	16	liu	liu	PROPN
admet-553	403	17	.	.	PUNCT
admet-553	404	1	analysis	analysis	NOUN
admet-553	404	2	of	of	ADP
admet-553	404	3	immobilized	immobilized	ADJ
admet-553	404	4	artificial	artificial	ADJ
admet-553	404	5	membrane	membrane	NOUN
admet-553	404	6	retention	retention	NOUN
admet-553	404	7	factors	factor	NOUN
admet-553	404	8	for	for	ADP
admet-553	404	9	both	both	CCONJ
admet-553	404	10	neutral	neutral	ADJ
admet-553	404	11	and	and	CCONJ
admet-553	404	12	ionic	ionic	ADJ
admet-553	404	13	species	specie	NOUN
admet-553	404	14	.	.	PUNCT
admet-553	405	1	journal	journal	PROPN
admet-553	405	2	of	of	ADP
admet-553	405	3	chromatography	chromatography	NOUN
admet-553	405	4	a	a	DET
admet-553	405	5	1298	1298	NUM
admet-553	405	6	(	(	PUNCT
admet-553	405	7	2013	2013	NUM
admet-553	405	8	)	)	PUNCT
admet-553	405	9	44	44	NUM
admet-553	405	10	-	-	SYM
admet-553	405	11	49	49	NUM
admet-553	405	12	.	.	PUNCT
admet-553	406	1	[	[	X
admet-553	406	2	45	45	NUM
admet-553	406	3	]	]	X
admet-553	406	4	g.	g.	NOUN
admet-553	406	5	ermondi	ermondi	PROPN
admet-553	406	6	,	,	PUNCT
admet-553	406	7	m.	m.	NOUN
admet-553	406	8	vallaro	vallaro	NOUN
admet-553	406	9	,	,	PUNCT
admet-553	406	10	g.	g.	PROPN
admet-553	406	11	caron	caron	PROPN
admet-553	406	12	.	.	PUNCT
admet-553	407	1	learning	learn	VERB
admet-553	407	2	how	how	SCONJ
admet-553	407	3	to	to	PART
admet-553	407	4	use	use	VERB
admet-553	407	5	iam	iam	PROPN
admet-553	407	6	chromatography	chromatography	NOUN
admet-553	407	7	for	for	ADP
admet-553	407	8	predicting	predict	VERB
admet-553	407	9	permeability	permeability	NOUN
admet-553	407	10	.	.	PUNCT
admet-553	408	1	european	european	PROPN
admet-553	408	2	journal	journal	PROPN
admet-553	408	3	of	of	ADP
admet-553	408	4	pharmaceutical	pharmaceutical	PROPN
admet-553	408	5	sciences	science	NOUN
admet-553	408	6	114	114	NUM
admet-553	408	7	(	(	PUNCT
admet-553	408	8	2018	2018	NUM
admet-553	408	9	)	)	PUNCT
admet-553	408	10	385	385	NUM
admet-553	408	11	-	-	SYM
admet-553	408	12	390	390	NUM
admet-553	408	13	.	.	PUNCT
admet-553	409	1	[	[	X
admet-553	409	2	46	46	NUM
admet-553	409	3	]	]	X
admet-553	409	4	f.	f.	PROPN
admet-553	409	5	barbato	barbato	PROPN
admet-553	409	6	.	.	PUNCT
admet-553	410	1	the	the	DET
admet-553	410	2	use	use	NOUN
admet-553	410	3	of	of	ADP
admet-553	410	4	immobilized	immobilized	ADJ
admet-553	410	5	artificial	artificial	ADJ
admet-553	410	6	membrane	membrane	NOUN
admet-553	410	7	(	(	PUNCT
admet-553	410	8	iam	iam	PROPN
admet-553	410	9	)	)	PUNCT
admet-553	410	10	chromatography	chromatography	NOUN
admet-553	410	11	for	for	ADP
admet-553	410	12	determination	determination	NOUN
admet-553	410	13	of	of	ADP
admet-553	410	14	lipophilicity	lipophilicity	NOUN
admet-553	410	15	.	.	PUNCT
admet-553	411	1	current	current	ADJ
admet-553	411	2	computer	computer	NOUN
admet-553	411	3	-	-	PUNCT
admet-553	411	4	aided	aid	VERB
admet-553	411	5	drug	drug	NOUN
admet-553	411	6	design	design	NOUN
admet-553	411	7	2	2	NUM
admet-553	411	8	(	(	PUNCT
admet-553	411	9	2006	2006	NUM
admet-553	411	10	)	)	PUNCT
admet-553	411	11	341	341	NUM
admet-553	411	12	-	-	SYM
admet-553	411	13	352	352	NUM
admet-553	411	14	.	.	PUNCT
admet-553	412	1	[	[	X
admet-553	412	2	47	47	NUM
admet-553	412	3	]	]	X
admet-553	412	4	s.t.j	s.t.j	NOUN
admet-553	412	5	.	.	PUNCT
admet-553	412	6	droge	droge	PROPN
admet-553	412	7	.	.	PUNCT
admet-553	413	1	dealing	deal	VERB
admet-553	413	2	with	with	ADP
admet-553	413	3	confounding	confound	VERB
admet-553	413	4	ph	ph	ADJ
admet-553	413	5	-	-	ADJ
admet-553	413	6	dependent	dependent	ADJ
admet-553	413	7	surface	surface	NOUN
admet-553	413	8	charges	charge	NOUN
admet-553	413	9	in	in	ADP
admet-553	413	10	immobilized	immobilized	ADJ
admet-553	413	11	artificial	artificial	ADJ
admet-553	413	12	hplc	hplc	NOUN
admet-553	413	13	columns	column	NOUN
admet-553	413	14	.	.	PUNCT
admet-553	414	1	analytical	analytical	ADJ
admet-553	414	2	chemistry	chemistry	NOUN
admet-553	414	3	88	88	NUM
admet-553	414	4	(	(	PUNCT
admet-553	414	5	2016	2016	NUM
admet-553	414	6	)	)	PUNCT
admet-553	414	7	960	960	NUM
admet-553	414	8	-	-	SYM
admet-553	414	9	967	967	NUM
admet-553	414	10	.	.	PUNCT
admet-553	415	1	[	[	X
admet-553	415	2	48	48	NUM
admet-553	415	3	]	]	X
admet-553	415	4	m.r	m.r	PROPN
admet-553	415	5	.	.	PROPN
admet-553	415	6	ledbetter	ledbetter	PROPN
admet-553	415	7	,	,	PUNCT
admet-553	415	8	s.	s.	PROPN
admet-553	415	9	gutsell	gutsell	PROPN
admet-553	415	10	,	,	PUNCT
admet-553	415	11	g.	g.	PROPN
admet-553	415	12	hodges	hodges	PROPN
admet-553	415	13	,	,	PUNCT
admet-553	415	14	s.	s.	PROPN
admet-553	415	15	o’connor	o’connor	PROPN
admet-553	415	16	,	,	PUNCT
admet-553	415	17	j.c	j.c	PROPN
admet-553	415	18	.	.	PROPN
admet-553	415	19	madden	madden	PROPN
admet-553	415	20	,	,	PUNCT
admet-553	415	21	p.h	p.h	PROPN
admet-553	415	22	.	.	PROPN
admet-553	415	23	rowe	rowe	PROPN
admet-553	415	24	,	,	PUNCT
admet-553	415	25	m.t.d	m.t.d	PROPN
admet-553	415	26	.	.	PUNCT
admet-553	415	27	cronin	cronin	PROPN
admet-553	415	28	.	.	PUNCT
admet-553	416	1	prediction	prediction	NOUN
admet-553	416	2	of	of	ADP
admet-553	416	3	immobilized	immobilized	ADJ
admet-553	416	4	artificial	artificial	ADJ
admet-553	416	5	membrane	membrane	NOUN
admet-553	416	6	chromatography	chromatography	NOUN
admet-553	416	7	retention	retention	NOUN
admet-553	416	8	factors	factor	NOUN
admet-553	416	9	using	use	VERB
admet-553	416	10	theoretical	theoretical	ADJ
admet-553	416	11	molecular	molecular	ADJ
admet-553	416	12	fragments	fragment	NOUN
admet-553	416	13	and	and	CCONJ
admet-553	416	14	structural	structural	ADJ
admet-553	416	15	features	feature	NOUN
admet-553	416	16	.	.	PUNCT
admet-553	417	1	sar	sar	PROPN
admet-553	417	2	and	and	CCONJ
admet-553	417	3	qsar	qsar	VERB
admet-553	417	4	in	in	ADP
admet-553	417	5	environmental	environmental	ADJ
admet-553	417	6	research	research	NOUN
admet-553	417	7	24	24	NUM
admet-553	417	8	(	(	PUNCT
admet-553	417	9	2013	2013	NUM
admet-553	417	10	)	)	PUNCT
admet-553	417	11	661	661	NUM
admet-553	417	12	-	-	SYM
admet-553	417	13	678	678	NUM
admet-553	417	14	.	.	PUNCT
admet-553	418	1	[	[	X
admet-553	418	2	49	49	NUM
admet-553	418	3	]	]	X
admet-553	418	4	b.h	b.h	PROPN
admet-553	418	5	.	.	PROPN
admet-553	418	6	stewart	stewart	PROPN
admet-553	418	7	,	,	PUNCT
admet-553	418	8	f.y	f.y	PROPN
admet-553	418	9	.	.	PROPN
admet-553	418	10	chung	chung	PROPN
admet-553	418	11	,	,	PUNCT
admet-553	418	12	b.	b.	PROPN
admet-553	418	13	tait	tait	PROPN
admet-553	418	14	,	,	PUNCT
admet-553	418	15	c.j	c.j	PROPN
admet-553	418	16	.	.	PROPN
admet-553	418	17	blankley	blankley	PROPN
admet-553	418	18	,	,	PUNCT
admet-553	418	19	o.h	o.h	PROPN
admet-553	418	20	.	.	PROPN
admet-553	418	21	chan	chan	PROPN
admet-553	418	22	.	.	PUNCT
admet-553	419	1	hydrophobicity	hydrophobicity	NOUN
admet-553	419	2	of	of	ADP
admet-553	419	3	hiv	hiv	PROPN
admet-553	419	4	protease	protease	NOUN
admet-553	419	5	inhibitors	inhibitor	NOUN
admet-553	419	6	by	by	ADP
admet-553	419	7	immobilized	immobilized	ADJ
admet-553	419	8	artificial	artificial	ADJ
admet-553	419	9	membrane	membrane	NOUN
admet-553	419	10	chromatography	chromatography	NOUN
admet-553	419	11	:	:	PUNCT
admet-553	419	12	application	application	NOUN
admet-553	419	13	and	and	CCONJ
admet-553	419	14	significance	significance	NOUN
admet-553	419	15	to	to	ADP
admet-553	419	16	drug	drug	NOUN
admet-553	419	17	transport	transport	NOUN
admet-553	419	18	.	.	PUNCT
admet-553	420	1	pharmaceutical	pharmaceutical	ADJ
admet-553	420	2	research	research	NOUN
admet-553	420	3	15	15	NUM
admet-553	420	4	(	(	PUNCT
admet-553	420	5	1998	1998	NUM
admet-553	420	6	)	)	PUNCT
admet-553	420	7	1401	1401	NUM
admet-553	420	8	-	-	SYM
admet-553	420	9	1406	1406	NUM
admet-553	420	10	.	.	PUNCT
admet-553	421	1	[	[	X
admet-553	421	2	50	50	NUM
admet-553	421	3	]	]	PUNCT
admet-553	421	4	t.	t.	PROPN
admet-553	421	5	osterberg	osterberg	PROPN
admet-553	421	6	,	,	PUNCT
admet-553	421	7	m.	m.	PROPN
admet-553	421	8	svensson	svensson	PROPN
admet-553	421	9	,	,	PUNCT
admet-553	421	10	p.	p.	PROPN
admet-553	421	11	lundahl	lundahl	PROPN
admet-553	421	12	.	.	PUNCT
admet-553	422	1	chromatographic	chromatographic	ADJ
admet-553	422	2	retention	retention	NOUN
admet-553	422	3	of	of	ADP
admet-553	422	4	drug	drug	NOUN
admet-553	422	5	molecules	molecule	NOUN
admet-553	422	6	on	on	ADP
admet-553	422	7	immobilized	immobilized	ADJ
admet-553	422	8	liposomes	liposome	NOUN
admet-553	422	9	prepared	prepare	VERB
admet-553	422	10	from	from	ADP
admet-553	422	11	egg	egg	NOUN
admet-553	422	12	phospholipids	phospholipid	NOUN
admet-553	422	13	and	and	CCONJ
admet-553	422	14	from	from	ADP
admet-553	422	15	chemically	chemically	ADV
admet-553	422	16	pure	pure	ADJ
admet-553	422	17	phospholipids	phospholipid	NOUN
admet-553	422	18	.	.	PUNCT
admet-553	423	1	european	european	PROPN
admet-553	423	2	journal	journal	PROPN
admet-553	423	3	of	of	ADP
admet-553	423	4	pharmaceutical	pharmaceutical	PROPN
admet-553	423	5	sciences	science	NOUN
admet-553	423	6	12	12	NUM
admet-553	423	7	(	(	PUNCT
admet-553	423	8	2001	2001	NUM
admet-553	423	9	)	)	PUNCT
admet-553	423	10	427	427	NUM
admet-553	423	11	-	-	SYM
admet-553	423	12	439	439	NUM
admet-553	423	13	.	.	PUNCT
admet-553	424	1	[	[	X
admet-553	424	2	51	51	NUM
admet-553	424	3	]	]	X
admet-553	424	4	e.c	e.c	PROPN
admet-553	424	5	.	.	PROPN
admet-553	424	6	chan	chan	PROPN
admet-553	424	7	,	,	PUNCT
admet-553	424	8	w.l	w.l	PROPN
admet-553	424	9	.	.	PROPN
admet-553	424	10	tan	tan	PROPN
admet-553	424	11	,	,	PUNCT
admet-553	424	12	p.c	p.c	PROPN
admet-553	424	13	.	.	PROPN
admet-553	424	14	ho	ho	PROPN
admet-553	424	15	,	,	PUNCT
admet-553	424	16	l.j	l.j	PROPN
admet-553	424	17	.	.	PROPN
admet-553	424	18	fang	fang	PROPN
admet-553	424	19	.	.	PUNCT
admet-553	425	1	modelling	model	VERB
admet-553	425	2	caco-2	caco-2	NUM
admet-553	425	3	permeability	permeability	NOUN
admet-553	425	4	of	of	ADP
admet-553	425	5	drugs	drug	NOUN
admet-553	425	6	using	use	VERB
admet-553	425	7	immobilized	immobilized	ADJ
admet-553	425	8	artificial	artificial	ADJ
admet-553	425	9	membrane	membrane	NOUN
admet-553	425	10	chromatography	chromatography	NOUN
admet-553	425	11	and	and	CCONJ
admet-553	425	12	physicochemical	physicochemical	ADJ
admet-553	425	13	descriptors	descriptor	NOUN
admet-553	425	14	.	.	PUNCT
admet-553	426	1	journal	journal	NOUN
admet-553	426	2	of	of	ADP
admet-553	426	3	chromatography	chromatography	NOUN
admet-553	426	4	a	a	DET
admet-553	426	5	1072	1072	NUM
admet-553	426	6	(	(	PUNCT
admet-553	426	7	2005	2005	NUM
admet-553	426	8	)	)	PUNCT
admet-553	426	9	159	159	NUM
admet-553	426	10	-	-	SYM
admet-553	426	11	168	168	NUM
admet-553	426	12	.	.	PUNCT
admet-553	427	1	admet	admet	PROPN
admet-553	427	2	&	&	CCONJ
admet-553	427	3	dmpk	dmpk	PROPN
admet-553	427	4	6(3	6(3	PROPN
admet-553	427	5	)	)	PUNCT
admet-553	427	6	(	(	PUNCT
admet-553	427	7	2018	2018	NUM
admet-553	427	8	)	)	PUNCT
admet-553	427	9	225	225	NUM
admet-553	427	10	-	-	SYM
admet-553	427	11	241	241	NUM
admet-553	427	12	iam	iam	PROPN
admet-553	427	13	chromatography	chromatography	NOUN
admet-553	427	14	in	in	ADP
admet-553	427	15	medicinal	medicinal	ADJ
admet-553	427	16	chemistry	chemistry	NOUN
admet-553	427	17	and	and	CCONJ
admet-553	427	18	environment	environment	NOUN
admet-553	427	19	doi	doi	PROPN
admet-553	427	20	:	:	PUNCT
admet-553	427	21	10.5599	10.5599	NUM
admet-553	427	22	/	/	SYM
admet-553	427	23	admet.553	admet.553	NOUN
admet-553	427	24	239	239	NUM
admet-553	427	25	[	[	X
admet-553	427	26	52	52	NUM
admet-553	427	27	]	]	PUNCT
admet-553	427	28	j.	j.	PROPN
admet-553	427	29	keldenich	keldenich	PROPN
admet-553	427	30	.	.	PUNCT
admet-553	428	1	measurement	measurement	NOUN
admet-553	428	2	and	and	CCONJ
admet-553	428	3	prediction	prediction	NOUN
admet-553	428	4	of	of	ADP
admet-553	428	5	oral	oral	ADJ
admet-553	428	6	absorption	absorption	NOUN
admet-553	428	7	.	.	PUNCT
admet-553	429	1	chemistry	chemistry	NOUN
admet-553	429	2	and	and	CCONJ
admet-553	429	3	biodiversity	biodiversity	NOUN
admet-553	429	4	6	6	NUM
admet-553	429	5	(	(	PUNCT
admet-553	429	6	2009	2009	NUM
admet-553	429	7	)	)	PUNCT
admet-553	429	8	2000	2000	NUM
admet-553	429	9	-	-	SYM
admet-553	429	10	2013	2013	NUM
admet-553	429	11	.	.	PUNCT
admet-553	430	1	[	[	X
admet-553	430	2	53	53	NUM
admet-553	430	3	]	]	X
admet-553	430	4	c.h	c.h	PROPN
admet-553	430	5	.	.	PROPN
admet-553	430	6	yoon	yoon	PROPN
admet-553	430	7	,	,	PUNCT
admet-553	430	8	b.s	b.s	PROPN
admet-553	430	9	.	.	PROPN
admet-553	430	10	shin	shin	PROPN
admet-553	430	11	,	,	PUNCT
admet-553	430	12	h.s	h.s	PROPN
admet-553	430	13	.	.	PROPN
admet-553	430	14	chang	chang	PROPN
admet-553	430	15	,	,	PUNCT
admet-553	430	16	l.s	l.s	PROPN
admet-553	430	17	.	.	PROPN
admet-553	430	18	kwon	kwon	PROPN
admet-553	430	19	,	,	PUNCT
admet-553	430	20	h.y	h.y	PROPN
admet-553	430	21	.	.	PROPN
admet-553	430	22	kim	kim	PROPN
admet-553	430	23	,	,	PUNCT
admet-553	430	24	s.e	s.e	PROPN
admet-553	430	25	.	.	PROPN
admet-553	430	26	yoo	yoo	PROPN
admet-553	430	27	,	,	PUNCT
admet-553	430	28	s.d	s.d	PROPN
admet-553	430	29	.	.	PROPN
admet-553	430	30	yoo	yoo	PROPN
admet-553	430	31	.	.	PUNCT
admet-553	430	32	rapid	rapid	ADJ
admet-553	430	33	screening	screening	NOUN
admet-553	430	34	of	of	ADP
admet-553	430	35	drug	drug	NOUN
admet-553	430	36	absorption	absorption	NOUN
admet-553	430	37	potential	potential	NOUN
admet-553	430	38	using	use	VERB
admet-553	430	39	the	the	DET
admet-553	430	40	immobilized	immobilized	ADJ
admet-553	430	41	artificial	artificial	ADJ
admet-553	430	42	membrane	membrane	NOUN
admet-553	430	43	phosphatidylcholine	phosphatidylcholine	NOUN
admet-553	430	44	column	column	NOUN
admet-553	430	45	and	and	CCONJ
admet-553	430	46	molar	molar	ADJ
admet-553	430	47	volume	volume	NOUN
admet-553	430	48	.	.	PUNCT
admet-553	431	1	chromatographia	chromatographia	PROPN
admet-553	431	2	60	60	NUM
admet-553	431	3	(	(	PUNCT
admet-553	431	4	2004	2004	NUM
admet-553	431	5	)	)	PUNCT
admet-553	431	6	399	399	NUM
admet-553	431	7	-	-	SYM
admet-553	431	8	404	404	NUM
admet-553	431	9	.	.	PUNCT
admet-553	432	1	[	[	X
admet-553	432	2	54	54	NUM
admet-553	432	3	]	]	X
admet-553	432	4	b.s	b.s	PROPN
admet-553	432	5	.	.	PROPN
admet-553	432	6	shin	shin	PROPN
admet-553	432	7	,	,	PUNCT
admet-553	432	8	c.h	c.h	PROPN
admet-553	432	9	.	.	PROPN
admet-553	432	10	yoon	yoon	PROPN
admet-553	432	11	,	,	PUNCT
admet-553	432	12	j.p	j.p	PROPN
admet-553	432	13	.	.	PROPN
admet-553	432	14	balthasar	balthasar	PROPN
admet-553	432	15	,	,	PUNCT
admet-553	432	16	b.y	b.y	PROPN
admet-553	432	17	.	.	PROPN
admet-553	432	18	choi	choi	PROPN
admet-553	432	19	,	,	PUNCT
admet-553	432	20	s.h	s.h	PROPN
admet-553	432	21	.	.	PROPN
admet-553	432	22	hong	hong	PROPN
admet-553	432	23	,	,	PUNCT
admet-553	432	24	h.j	h.j	PROPN
admet-553	432	25	.	.	PROPN
admet-553	432	26	kim	kim	PROPN
admet-553	432	27	,	,	PUNCT
admet-553	432	28	j.b	j.b	PROPN
admet-553	432	29	.	.	PROPN
admet-553	432	30	lee	lee	PROPN
admet-553	432	31	,	,	PUNCT
admet-553	432	32	s.w	s.w	PROPN
admet-553	432	33	.	.	PROPN
admet-553	432	34	hwang	hwang	PROPN
admet-553	432	35	,	,	PUNCT
admet-553	432	36	s.d	s.d	PROPN
admet-553	432	37	.	.	PROPN
admet-553	432	38	yoo	yoo	PROPN
admet-553	432	39	.	.	PUNCT
admet-553	433	1	prediction	prediction	NOUN
admet-553	433	2	of	of	ADP
admet-553	433	3	drug	drug	NOUN
admet-553	433	4	bioavailability	bioavailability	NOUN
admet-553	433	5	in	in	ADP
admet-553	433	6	humans	human	NOUN
admet-553	433	7	using	use	VERB
admet-553	433	8	immobilized	immobilized	ADJ
admet-553	433	9	artificial	artificial	ADJ
admet-553	433	10	membrane	membrane	NOUN
admet-553	433	11	phosphatidylcholine	phosphatidylcholine	NOUN
admet-553	433	12	column	column	NOUN
admet-553	433	13	chromatography	chromatography	NOUN
admet-553	433	14	and	and	CCONJ
admet-553	433	15	in	in	ADP
admet-553	433	16	vitro	vitro	X
admet-553	433	17	hepatic	hepatic	ADJ
admet-553	433	18	metabolic	metabolic	NOUN
admet-553	433	19	clearance	clearance	NOUN
admet-553	433	20	.	.	PUNCT
admet-553	434	1	biomedical	biomedical	ADJ
admet-553	434	2	chromatography	chromatography	NOUN
admet-553	434	3	23	23	NUM
admet-553	434	4	(	(	PUNCT
admet-553	434	5	2009	2009	NUM
admet-553	434	6	)	)	PUNCT
admet-553	434	7	764	764	NUM
admet-553	434	8	-	-	SYM
admet-553	434	9	769	769	NUM
admet-553	434	10	.	.	PUNCT
admet-553	435	1	[	[	X
admet-553	435	2	55	55	NUM
admet-553	435	3	]	]	X
admet-553	435	4	t.e	t.e	PROPN
admet-553	435	5	.	.	PROPN
admet-553	435	6	yen	yen	PROPN
admet-553	435	7	,	,	PUNCT
admet-553	435	8	s.	s.	PROPN
admet-553	435	9	agatonovickustrin	agatonovickustrin	PROPN
admet-553	435	10	,	,	PUNCT
admet-553	435	11	a.m.	a.m.	PROPN
admet-553	435	12	evans	evans	PROPN
admet-553	435	13	,	,	PUNCT
admet-553	435	14	r.l	r.l	PROPN
admet-553	435	15	.	.	PROPN
admet-553	435	16	nation	nation	PROPN
admet-553	435	17	,	,	PUNCT
admet-553	435	18	j.	j.	PROPN
admet-553	435	19	ryand	ryand	PROPN
admet-553	435	20	.	.	PUNCT
admet-553	436	1	prediction	prediction	NOUN
admet-553	436	2	of	of	ADP
admet-553	436	3	drug	drug	NOUN
admet-553	436	4	absorption	absorption	NOUN
admet-553	436	5	based	base	VERB
admet-553	436	6	on	on	ADP
admet-553	436	7	immobilized	immobilized	ADJ
admet-553	436	8	artificial	artificial	ADJ
admet-553	436	9	membrane	membrane	NOUN
admet-553	436	10	(	(	PUNCT
admet-553	436	11	iam	iam	PROPN
admet-553	436	12	)	)	PUNCT
admet-553	436	13	chromatography	chromatography	NOUN
admet-553	436	14	separation	separation	NOUN
admet-553	436	15	and	and	CCONJ
admet-553	436	16	calculated	calculate	VERB
admet-553	436	17	molecular	molecular	ADJ
admet-553	436	18	descriptors	descriptor	NOUN
admet-553	436	19	.	.	PUNCT
admet-553	437	1	journal	journal	NOUN
admet-553	437	2	of	of	ADP
admet-553	437	3	pharmaceutical	pharmaceutical	NOUN
admet-553	437	4	and	and	CCONJ
admet-553	437	5	biomedical	biomedical	ADJ
admet-553	437	6	analysis	analysis	NOUN
admet-553	437	7	38	38	NUM
admet-553	437	8	(	(	PUNCT
admet-553	437	9	2005	2005	NUM
admet-553	437	10	)	)	PUNCT
admet-553	437	11	472	472	NUM
admet-553	437	12	-	-	SYM
admet-553	437	13	478	478	NUM
admet-553	437	14	.	.	PUNCT
admet-553	438	1	[	[	X
admet-553	438	2	56	56	NUM
admet-553	438	3	]	]	X
admet-553	438	4	t.	t.	NOUN
admet-553	438	5	salminen	salminen	PROPN
admet-553	438	6	,	,	PUNCT
admet-553	438	7	a.	a.	PROPN
admet-553	438	8	pulli	pulli	PROPN
admet-553	438	9	,	,	PUNCT
admet-553	438	10	j.	j.	PROPN
admet-553	438	11	taskinen	taskinen	PROPN
admet-553	438	12	.	.	PUNCT
admet-553	438	13	relationship	relationship	NOUN
admet-553	438	14	between	between	ADP
admet-553	438	15	immobilized	immobilized	ADJ
admet-553	438	16	artificial	artificial	ADJ
admet-553	438	17	membrane	membrane	NOUN
admet-553	438	18	chromatographic	chromatographic	ADJ
admet-553	438	19	retention	retention	NOUN
admet-553	438	20	and	and	CCONJ
admet-553	438	21	the	the	DET
admet-553	438	22	brain	brain	NOUN
admet-553	438	23	penetration	penetration	NOUN
admet-553	438	24	of	of	ADP
admet-553	438	25	structurally	structurally	ADV
admet-553	438	26	diverse	diverse	ADJ
admet-553	438	27	drugs	drug	NOUN
admet-553	438	28	.	.	PUNCT
admet-553	439	1	journal	journal	NOUN
admet-553	439	2	of	of	ADP
admet-553	439	3	pharmaceutical	pharmaceutical	NOUN
admet-553	439	4	and	and	CCONJ
admet-553	439	5	biomedical	biomedical	ADJ
admet-553	439	6	analysis	analysis	NOUN
admet-553	439	7	15	15	NUM
admet-553	439	8	(	(	PUNCT
admet-553	439	9	1997	1997	NUM
admet-553	439	10	)	)	PUNCT
admet-553	439	11	469	469	NUM
admet-553	439	12	-	-	NOUN
admet-553	439	13	477	477	NUM
admet-553	439	14	.	.	PUNCT
admet-553	440	1	[	[	X
admet-553	440	2	57	57	NUM
admet-553	440	3	]	]	PUNCT
admet-553	440	4	a.	a.	NOUN
admet-553	440	5	reichel	reichel	PROPN
admet-553	440	6	,	,	PUNCT
admet-553	440	7	d.j	d.j	PROPN
admet-553	440	8	.	.	PROPN
admet-553	440	9	begley	begley	PROPN
admet-553	440	10	.	.	PUNCT
admet-553	441	1	potential	potential	NOUN
admet-553	441	2	of	of	ADP
admet-553	441	3	immobilized	immobilized	ADJ
admet-553	441	4	artificial	artificial	ADJ
admet-553	441	5	membranes	membrane	NOUN
admet-553	441	6	for	for	ADP
admet-553	441	7	predicting	predict	VERB
admet-553	441	8	drug	drug	NOUN
admet-553	441	9	penetration	penetration	NOUN
admet-553	441	10	across	across	ADP
admet-553	441	11	the	the	DET
admet-553	441	12	blood	blood	NOUN
admet-553	441	13	-	-	PUNCT
admet-553	441	14	brain	brain	NOUN
admet-553	441	15	barrier	barrier	NOUN
admet-553	441	16	.	.	PUNCT
admet-553	442	1	pharmaceutical	pharmaceutical	NOUN
admet-553	442	2	research	research	NOUN
admet-553	442	3	15	15	NUM
admet-553	442	4	(	(	PUNCT
admet-553	442	5	1998	1998	NUM
admet-553	442	6	)	)	PUNCT
admet-553	442	7	1270	1270	NUM
admet-553	442	8	-	-	SYM
admet-553	442	9	1274	1274	NUM
admet-553	442	10	.	.	PUNCT
admet-553	443	1	[	[	X
admet-553	443	2	58	58	NUM
admet-553	443	3	]	]	X
admet-553	443	4	f.	f.	PROPN
admet-553	443	5	pehourcq	pehourcq	PROPN
admet-553	443	6	,	,	PUNCT
admet-553	443	7	m.	m.	NOUN
admet-553	443	8	matoga	matoga	NOUN
admet-553	443	9	,	,	PUNCT
admet-553	443	10	b.	b.	PROPN
admet-553	443	11	bannwarth	bannwarth	PROPN
admet-553	443	12	.	.	PUNCT
admet-553	444	1	diffusion	diffusion	NOUN
admet-553	444	2	of	of	ADP
admet-553	444	3	arylpropionate	arylpropionate	NOUN
admet-553	444	4	nonsteroidal	nonsteroidal	NOUN
admet-553	444	5	anti	anti	ADJ
admet-553	444	6	-	-	ADJ
admet-553	444	7	inflammatory	inflammatory	ADJ
admet-553	444	8	drugs	drug	NOUN
admet-553	444	9	into	into	ADP
admet-553	444	10	the	the	DET
admet-553	444	11	cerebrospinal	cerebrospinal	ADJ
admet-553	444	12	fluid	fluid	NOUN
admet-553	444	13	:	:	PUNCT
admet-553	444	14	a	a	DET
admet-553	444	15	quantitative	quantitative	ADJ
admet-553	444	16	structure	structure	NOUN
admet-553	444	17	-	-	PUNCT
admet-553	444	18	activity	activity	NOUN
admet-553	444	19	relationship	relationship	NOUN
admet-553	444	20	approach	approach	NOUN
admet-553	444	21	.	.	PUNCT
admet-553	445	1	fundamental	fundamental	ADJ
admet-553	445	2	and	and	CCONJ
admet-553	445	3	clinical	clinical	ADJ
admet-553	445	4	pharmacology	pharmacology	NOUN
admet-553	445	5	18	18	NUM
admet-553	445	6	(	(	PUNCT
admet-553	445	7	2004	2004	NUM
admet-553	445	8	)	)	PUNCT
admet-553	445	9	65	65	NUM
admet-553	445	10	-	-	SYM
admet-553	445	11	70	70	NUM
admet-553	445	12	.	.	PUNCT
admet-553	446	1	[	[	X
admet-553	446	2	59	59	NUM
admet-553	446	3	]	]	PUNCT
admet-553	446	4	l.	l.	PROPN
admet-553	446	5	grumetto	grumetto	PROPN
admet-553	446	6	,	,	PUNCT
admet-553	446	7	c.	c.	PROPN
admet-553	446	8	carpentiero	carpentiero	PROPN
admet-553	446	9	,	,	PUNCT
admet-553	446	10	f.	f.	PROPN
admet-553	446	11	barbato	barbato	PROPN
admet-553	446	12	.	.	PUNCT
admet-553	447	1	lipophilic	lipophilic	ADJ
admet-553	447	2	and	and	CCONJ
admet-553	447	3	electrostatic	electrostatic	ADJ
admet-553	447	4	forces	force	NOUN
admet-553	447	5	encoded	encode	VERB
admet-553	447	6	in	in	ADP
admet-553	447	7	iam	iam	PROPN
admet-553	447	8	-	-	PUNCT
admet-553	447	9	hplc	hplc	NOUN
admet-553	447	10	indexes	index	NOUN
admet-553	447	11	of	of	ADP
admet-553	447	12	basic	basic	ADJ
admet-553	447	13	drugs	drug	NOUN
admet-553	447	14	:	:	PUNCT
admet-553	447	15	their	their	PRON
admet-553	447	16	role	role	NOUN
admet-553	447	17	in	in	ADP
admet-553	447	18	membrane	membrane	NOUN
admet-553	447	19	partition	partition	NOUN
admet-553	447	20	and	and	CCONJ
admet-553	447	21	their	their	PRON
admet-553	447	22	relationships	relationship	NOUN
admet-553	447	23	with	with	ADP
admet-553	447	24	bbb	bbb	PROPN
admet-553	447	25	passage	passage	NOUN
admet-553	447	26	data	datum	NOUN
admet-553	447	27	.	.	PUNCT
admet-553	448	1	european	european	PROPN
admet-553	448	2	journal	journal	PROPN
admet-553	448	3	of	of	ADP
admet-553	448	4	pharmaceutical	pharmaceutical	PROPN
admet-553	448	5	sciences	science	NOUN
admet-553	448	6	45	45	NUM
admet-553	448	7	(	(	PUNCT
admet-553	448	8	2012	2012	NUM
admet-553	448	9	)	)	PUNCT
admet-553	448	10	685	685	NUM
admet-553	448	11	-	-	SYM
admet-553	448	12	692	692	NUM
admet-553	448	13	.	.	PUNCT
admet-553	449	1	[	[	X
admet-553	449	2	60	60	NUM
admet-553	449	3	]	]	X
admet-553	449	4	c.h	c.h	PROPN
admet-553	449	5	.	.	PROPN
admet-553	449	6	yoon	yoon	PROPN
admet-553	449	7	,	,	PUNCT
admet-553	449	8	s.j	s.j	PROPN
admet-553	449	9	.	.	PROPN
admet-553	449	10	kim	kim	PROPN
admet-553	449	11	,	,	PUNCT
admet-553	449	12	b.s	b.s	PROPN
admet-553	449	13	.	.	PROPN
admet-553	449	14	shin	shin	PROPN
admet-553	449	15	,	,	PUNCT
admet-553	449	16	k.c	k.c	PROPN
admet-553	449	17	.	.	PROPN
admet-553	449	18	lee	lee	PROPN
admet-553	449	19	,	,	PUNCT
admet-553	450	1	s.d	s.d	PROPN
admet-553	450	2	.	.	PROPN
admet-553	450	3	yo	yo	PROPN
admet-553	450	4	.	.	PUNCT
admet-553	451	1	rapid	rapid	ADJ
admet-553	451	2	screening	screening	NOUN
admet-553	451	3	of	of	ADP
admet-553	451	4	blood	blood	NOUN
admet-553	451	5	-	-	PUNCT
admet-553	451	6	brain	brain	NOUN
admet-553	451	7	barrier	barrier	NOUN
admet-553	451	8	penetration	penetration	NOUN
admet-553	451	9	of	of	ADP
admet-553	451	10	drugs	drug	NOUN
admet-553	451	11	using	use	VERB
admet-553	451	12	the	the	DET
admet-553	451	13	immobilized	immobilized	ADJ
admet-553	451	14	artificial	artificial	ADJ
admet-553	451	15	membrane	membrane	NOUN
admet-553	451	16	phosphatidylcholine	phosphatidylcholine	NOUN
admet-553	451	17	column	column	NOUN
admet-553	451	18	chromatography	chromatography	NOUN
admet-553	451	19	.	.	PUNCT
admet-553	452	1	journal	journal	PROPN
admet-553	452	2	of	of	ADP
admet-553	452	3	biomolecular	biomolecular	ADJ
admet-553	452	4	screening	screen	VERB
admet-553	452	5	11	11	NUM
admet-553	452	6	(	(	PUNCT
admet-553	452	7	2006	2006	NUM
admet-553	452	8	)	)	PUNCT
admet-553	452	9	13	13	NUM
admet-553	452	10	-	-	SYM
admet-553	452	11	20	20	NUM
admet-553	452	12	.	.	PUNCT
admet-553	453	1	[	[	X
admet-553	453	2	61	61	NUM
admet-553	453	3	]	]	X
admet-553	453	4	f.	f.	PROPN
admet-553	453	5	barbato	barbato	PROPN
admet-553	453	6	,	,	PUNCT
admet-553	453	7	b.	b.	PROPN
admet-553	453	8	cappello	cappello	PROPN
admet-553	453	9	,	,	PUNCT
admet-553	453	10	a.	a.	PROPN
admet-553	453	11	miro	miro	PROPN
admet-553	453	12	,	,	PUNCT
admet-553	453	13	m.i	m.i	PROPN
admet-553	453	14	.	.	PROPN
admet-553	453	15	la	la	PROPN
admet-553	453	16	rotonda	rotonda	PROPN
admet-553	453	17	,	,	PUNCT
admet-553	453	18	f.	f.	PROPN
admet-553	453	19	quaglia	quaglia	PROPN
admet-553	453	20	.	.	PUNCT
admet-553	454	1	chromatographic	chromatographic	ADJ
admet-553	454	2	indexes	index	NOUN
admet-553	454	3	on	on	ADP
admet-553	454	4	immobilized	immobilized	ADJ
admet-553	454	5	artificial	artificial	ADJ
admet-553	454	6	membranes	membrane	NOUN
admet-553	454	7	for	for	ADP
admet-553	454	8	the	the	DET
admet-553	454	9	prediction	prediction	NOUN
admet-553	454	10	of	of	ADP
admet-553	454	11	transdermal	transdermal	ADJ
admet-553	454	12	transport	transport	NOUN
admet-553	454	13	of	of	ADP
admet-553	454	14	drugs	drug	NOUN
admet-553	454	15	.	.	PUNCT
admet-553	455	1	farmaco	farmaco	PROPN
admet-553	455	2	53	53	NUM
admet-553	455	3	(	(	PUNCT
admet-553	455	4	1998	1998	NUM
admet-553	455	5	)	)	PUNCT
admet-553	455	6	655	655	NUM
admet-553	455	7	-	-	PUNCT
admet-553	455	8	661	661	NUM
admet-553	455	9	.	.	PUNCT
admet-553	456	1	[	[	X
admet-553	456	2	62	62	NUM
admet-553	456	3	]	]	X
admet-553	456	4	b.r	b.r	PROPN
admet-553	456	5	.	.	PROPN
admet-553	456	6	berridge	berridge	PROPN
admet-553	456	7	,	,	PUNCT
admet-553	456	8	l.a	l.a	PROPN
admet-553	456	9	.	.	PROPN
admet-553	456	10	chatman	chatman	PROPN
admet-553	456	11	,	,	PUNCT
admet-553	456	12	m.	m.	NOUN
admet-553	456	13	odin	odin	PROPN
admet-553	456	14	,	,	PUNCT
admet-553	456	15	a.e	a.e	PROPN
admet-553	456	16	.	.	PROPN
admet-553	456	17	schultze	schultze	PROPN
admet-553	456	18	,	,	PUNCT
admet-553	456	19	p.e	p.e	PROPN
admet-553	456	20	.	.	PROPN
admet-553	456	21	losco	losco	PROPN
admet-553	456	22	,	,	PUNCT
admet-553	456	23	j.t	j.t	PROPN
admet-553	456	24	.	.	PROPN
admet-553	456	25	meehan	meehan	PROPN
admet-553	456	26	,	,	PUNCT
admet-553	456	27	t.	t.	PROPN
admet-553	456	28	peters	peters	PROPN
admet-553	456	29	,	,	PUNCT
admet-553	456	30	s.l	s.l	PROPN
admet-553	456	31	.	.	PROPN
admet-553	456	32	vonderfecht	vonderfecht	PROPN
admet-553	456	33	.	.	PUNCT
admet-553	457	1	phospholipidosis	phospholipidosis	NOUN
admet-553	457	2	in	in	ADP
admet-553	457	3	nonclinical	nonclinical	ADJ
admet-553	457	4	toxicity	toxicity	NOUN
admet-553	457	5	studies	study	NOUN
admet-553	457	6	.	.	PUNCT
admet-553	458	1	toxicologic	toxicologic	ADJ
admet-553	458	2	pathology	pathology	NOUN
admet-553	458	3	35	35	NUM
admet-553	458	4	(	(	PUNCT
admet-553	458	5	2007	2007	NUM
admet-553	458	6	)	)	PUNCT
admet-553	458	7	325	325	NUM
admet-553	458	8	.	.	PUNCT
admet-553	459	1	[	[	X
admet-553	459	2	63	63	NUM
admet-553	459	3	]	]	SYM
admet-553	459	4	u.m	u.m	PROPN
admet-553	459	5	.	.	PROPN
admet-553	459	6	hanumegowda	hanumegowda	PROPN
admet-553	459	7	,	,	PUNCT
admet-553	459	8	g.	g.	PROPN
admet-553	459	9	wenke	wenke	NOUN
admet-553	459	10	,	,	PUNCT
admet-553	459	11	a.	a.	NOUN
admet-553	459	12	regueiroren	regueiroren	PROPN
admet-553	459	13	,	,	PUNCT
admet-553	459	14	r.	r.	PROPN
admet-553	459	15	yordanova	yordanova	PROPN
admet-553	459	16	,	,	PUNCT
admet-553	459	17	j.p	j.p	PROPN
admet-553	459	18	.	.	PROPN
admet-553	459	19	corradi	corradi	PROPN
admet-553	459	20	,	,	PUNCT
admet-553	459	21	s.p	s.p	PROPN
admet-553	459	22	.	.	PROPN
admet-553	459	23	adams	adams	PROPN
admet-553	459	24	.	.	PUNCT
admet-553	460	1	phospholipidosis	phospholipidosis	NOUN
admet-553	460	2	as	as	ADP
admet-553	460	3	a	a	DET
admet-553	460	4	function	function	NOUN
admet-553	460	5	of	of	ADP
admet-553	460	6	basicity	basicity	NOUN
admet-553	460	7	,	,	PUNCT
admet-553	460	8	lipophilicity	lipophilicity	NOUN
admet-553	460	9	and	and	CCONJ
admet-553	460	10	volume	volume	NOUN
admet-553	460	11	of	of	ADP
admet-553	460	12	distribution	distribution	NOUN
admet-553	460	13	of	of	ADP
admet-553	460	14	compounds	compound	NOUN
admet-553	460	15	.	.	PUNCT
admet-553	461	1	chemical	chemical	ADJ
admet-553	461	2	research	research	NOUN
admet-553	461	3	in	in	ADP
admet-553	461	4	toxicology	toxicology	NOUN
admet-553	461	5	23	23	NUM
admet-553	461	6	(	(	PUNCT
admet-553	461	7	2010	2010	NUM
admet-553	461	8	)	)	PUNCT
admet-553	461	9	749	749	NUM
admet-553	461	10	-	-	SYM
admet-553	461	11	755	755	NUM
admet-553	461	12	.	.	PUNCT
admet-553	462	1	[	[	X
admet-553	462	2	64	64	NUM
admet-553	462	3	]	]	X
admet-553	462	4	j.m	j.m	PROPN
admet-553	462	5	.	.	PROPN
admet-553	462	6	alakoskela	alakoskela	PROPN
admet-553	462	7	,	,	PUNCT
admet-553	462	8	p.	p.	NOUN
admet-553	462	9	vitovic	vitovic	ADJ
admet-553	462	10	,	,	PUNCT
admet-553	462	11	p.k.j	p.k.j	PROPN
admet-553	462	12	.	.	PUNCT
admet-553	463	1	kinnunen	kinnunen	PROPN
admet-553	463	2	.	.	PUNCT
admet-553	464	1	screening	screen	VERB
admet-553	464	2	for	for	ADP
admet-553	464	3	the	the	DET
admet-553	464	4	drugphospholipid	drugphospholipid	ADJ
admet-553	464	5	interaction	interaction	NOUN
admet-553	464	6	:	:	PUNCT
admet-553	464	7	correlation	correlation	NOUN
admet-553	464	8	to	to	ADP
admet-553	464	9	phospholipidosis	phospholipidosis	NOUN
admet-553	464	10	.	.	PUNCT
admet-553	465	1	chemmedchem	chemmedchem	PROPN
admet-553	465	2	4	4	NUM
admet-553	465	3	(	(	PUNCT
admet-553	465	4	2009	2009	NUM
admet-553	465	5	)	)	PUNCT
admet-553	465	6	1224	1224	NUM
admet-553	465	7	-	-	SYM
admet-553	465	8	1251	1251	NUM
admet-553	465	9	.	.	PUNCT
admet-553	466	1	[	[	X
admet-553	466	2	65	65	NUM
admet-553	466	3	]	]	X
admet-553	466	4	a.	a.	NOUN
admet-553	466	5	casartelli	casartelli	PROPN
admet-553	466	6	,	,	PUNCT
admet-553	466	7	m.	m.	NOUN
admet-553	466	8	bonato	bonato	PROPN
admet-553	466	9	,	,	PUNCT
admet-553	466	10	p.	p.	PROPN
admet-553	466	11	cristofori	cristofori	PROPN
admet-553	466	12	,	,	PUNCT
admet-553	466	13	f.	f.	PROPN
admet-553	466	14	crivellente	crivellente	PROPN
admet-553	466	15	,	,	PUNCT
admet-553	466	16	g.	g.	PROPN
admet-553	466	17	dal	dal	PROPN
admet-553	466	18	negro	negro	PROPN
admet-553	466	19	,	,	PUNCT
admet-553	466	20	i.	i.	NOUN
admet-553	466	21	masotto	masotto	PROPN
admet-553	466	22	,	,	PUNCT
admet-553	466	23	c.	c.	PROPN
admet-553	466	24	mutinelli	mutinelli	PROPN
admet-553	466	25	,	,	PUNCT
admet-553	466	26	k.	k.	PROPN
admet-553	466	27	valko	valko	PROPN
admet-553	466	28	,	,	PUNCT
admet-553	466	29	v.	v.	PROPN
admet-553	466	30	bonfante	bonfante	ADJ
admet-553	466	31	.	.	PUNCT
admet-553	467	1	a	a	DET
admet-553	467	2	cell	cell	NOUN
admet-553	467	3	-	-	PUNCT
admet-553	467	4	based	base	VERB
admet-553	467	5	approach	approach	NOUN
admet-553	467	6	for	for	ADP
admet-553	467	7	the	the	DET
admet-553	467	8	early	early	ADJ
admet-553	467	9	assessment	assessment	NOUN
admet-553	467	10	of	of	ADP
admet-553	467	11	the	the	DET
admet-553	467	12	phospholipidogenic	phospholipidogenic	ADJ
admet-553	467	13	potential	potential	NOUN
admet-553	467	14	in	in	ADP
admet-553	467	15	pharmaceutical	pharmaceutical	ADJ
admet-553	467	16	research	research	NOUN
admet-553	467	17	and	and	CCONJ
admet-553	467	18	drug	drug	NOUN
admet-553	467	19	development	development	NOUN
admet-553	467	20	.	.	PUNCT
admet-553	468	1	cell	cell	NOUN
admet-553	468	2	biology	biology	NOUN
admet-553	468	3	and	and	CCONJ
admet-553	468	4	toxicology	toxicology	NOUN
admet-553	468	5	19	19	NUM
admet-553	468	6	(	(	PUNCT
admet-553	468	7	2003	2003	NUM
admet-553	468	8	)	)	PUNCT
admet-553	468	9	161	161	NUM
admet-553	468	10	-	-	SYM
admet-553	468	11	176	176	NUM
admet-553	468	12	.	.	PUNCT
admet-553	469	1	[	[	X
admet-553	469	2	66	66	NUM
admet-553	469	3	]	]	PUNCT
admet-553	469	4	z.	z.	PROPN
admet-553	469	5	jiang	jiang	PROPN
admet-553	469	6	,	,	PUNCT
admet-553	469	7	j.	j.	PROPN
admet-553	469	8	reilly	reilly	PROPN
admet-553	469	9	.	.	PUNCT
admet-553	470	1	chromatography	chromatography	NOUN
admet-553	470	2	approaches	approach	VERB
admet-553	470	3	for	for	ADP
admet-553	470	4	early	early	ADJ
admet-553	470	5	screening	screening	NOUN
admet-553	470	6	of	of	ADP
admet-553	470	7	the	the	DET
admet-553	470	8	phospholipidosisinducing	phospholipidosisinducing	ADJ
admet-553	470	9	potential	potential	NOUN
admet-553	470	10	of	of	ADP
admet-553	470	11	pharmaceuticals	pharmaceutical	NOUN
admet-553	470	12	.	.	PUNCT
admet-553	471	1	journal	journal	NOUN
admet-553	471	2	of	of	ADP
admet-553	471	3	pharmaceutical	pharmaceutical	NOUN
admet-553	471	4	and	and	CCONJ
admet-553	471	5	biomedical	biomedical	ADJ
admet-553	471	6	analysis	analysis	NOUN
admet-553	471	7	61	61	NUM
admet-553	471	8	(	(	PUNCT
admet-553	471	9	2012	2012	NUM
admet-553	471	10	)	)	PUNCT
admet-553	471	11	184	184	NUM
admet-553	471	12	-	-	SYM
admet-553	471	13	190	190	NUM
admet-553	471	14	.	.	PUNCT
admet-553	472	1	[	[	X
admet-553	472	2	67	67	NUM
admet-553	472	3	]	]	PUNCT
admet-553	472	4	k.	k.	PROPN
admet-553	472	5	valko	valko	PROPN
admet-553	472	6	,	,	PUNCT
admet-553	472	7	s.b	s.b	PROPN
admet-553	472	8	.	.	PROPN
admet-553	472	9	nunhuck	nunhuck	PROPN
admet-553	472	10	,	,	PUNCT
admet-553	472	11	a.p	a.p	PROPN
admet-553	472	12	.	.	PROPN
admet-553	472	13	hill	hill	PROPN
admet-553	472	14	.	.	PUNCT
admet-553	473	1	estimating	estimate	VERB
admet-553	473	2	unbound	unbound	NOUN
admet-553	473	3	volume	volume	NOUN
admet-553	473	4	of	of	ADP
admet-553	473	5	distribution	distribution	NOUN
admet-553	473	6	and	and	CCONJ
admet-553	473	7	tissue	tissue	NOUN
admet-553	473	8	binding	bind	VERB
admet-553	473	9	by	by	ADP
admet-553	473	10	in	in	ADP
admet-553	473	11	vitro	vitro	X
admet-553	473	12	hplcbased	hplcbase	VERB
admet-553	473	13	human	human	ADJ
admet-553	473	14	serum	serum	NOUN
admet-553	473	15	albumin	albumin	NOUN
admet-553	473	16	and	and	CCONJ
admet-553	473	17	immobilized	immobilize	VERB
admet-553	473	18	artificial	artificial	ADJ
admet-553	473	19	membranebinding	membranebinding	ADJ
admet-553	473	20	measurements	measurement	NOUN
admet-553	473	21	.	.	PUNCT
admet-553	474	1	journal	journal	NOUN
admet-553	474	2	of	of	ADP
admet-553	474	3	pharmaceutical	pharmaceutical	PROPN
admet-553	474	4	sciences	science	NOUN
admet-553	474	5	100	100	NUM
admet-553	474	6	(	(	PUNCT
admet-553	474	7	2011	2011	NUM
admet-553	474	8	)	)	PUNCT
admet-553	474	9	849	849	NUM
admet-553	474	10	-	-	SYM
admet-553	474	11	862	862	NUM
admet-553	474	12	.	.	PUNCT
admet-553	475	1	[	[	X
admet-553	475	2	68	68	NUM
admet-553	475	3	]	]	PUNCT
admet-553	475	4	s.	s.	PROPN
admet-553	475	5	braggio	braggio	PROPN
admet-553	475	6	,	,	PUNCT
admet-553	475	7	d.	d.	PROPN
admet-553	475	8	montanari	montanari	PROPN
admet-553	475	9	,	,	PUNCT
admet-553	475	10	t.	t.	PROPN
admet-553	475	11	rossi	rossi	PROPN
admet-553	475	12	,	,	PUNCT
admet-553	475	13	e.	e.	PROPN
admet-553	475	14	ratti	ratti	PROPN
admet-553	475	15	.	.	PUNCT
admet-553	476	1	application	application	NOUN
admet-553	476	2	of	of	ADP
admet-553	476	3	drug	drug	NOUN
admet-553	476	4	efficiency	efficiency	NOUN
admet-553	476	5	index	index	NOUN
admet-553	476	6	in	in	ADP
admet-553	476	7	drug	drug	NOUN
admet-553	476	8	discovery	discovery	NOUN
admet-553	476	9	:	:	PUNCT
admet-553	476	10	a	a	DET
admet-553	476	11	strategy	strategy	NOUN
admet-553	476	12	towards	towards	ADP
admet-553	476	13	low	low	ADJ
admet-553	476	14	therapeutic	therapeutic	ADJ
admet-553	476	15	dose	dose	NOUN
admet-553	476	16	.	.	PUNCT
admet-553	477	1	expert	expert	ADJ
admet-553	477	2	opinion	opinion	NOUN
admet-553	477	3	in	in	ADP
admet-553	477	4	drug	drug	NOUN
admet-553	477	5	discovery	discovery	NOUN
admet-553	477	6	5	5	NUM
admet-553	477	7	(	(	PUNCT
admet-553	477	8	2010	2010	NUM
admet-553	477	9	)	)	PUNCT
admet-553	478	1	609–618	609–618	NUM
admet-553	478	2	.	.	PUNCT
admet-553	479	1	[	[	X
admet-553	479	2	69	69	NUM
admet-553	479	3	]	]	X
admet-553	479	4	g.w	g.w	PROPN
admet-553	479	5	.	.	PROPN
admet-553	479	6	amsden	amsden	PROPN
admet-553	479	7	.	.	PUNCT
admet-553	480	1	advanced	advanced	ADJ
admet-553	480	2	-	-	PUNCT
admet-553	480	3	generation	generation	NOUN
admet-553	480	4	macrolides	macrolide	NOUN
admet-553	480	5	:	:	PUNCT
admet-553	480	6	tissuedirected	tissuedirecte	VERB
admet-553	480	7	antibiotics	antibiotic	NOUN
admet-553	480	8	.	.	PUNCT
admet-553	481	1	international	international	ADJ
admet-553	481	2	journal	journal	PROPN
admet-553	481	3	of	of	ADP
admet-553	481	4	antimicrobial	antimicrobial	ADJ
admet-553	481	5	agents	agent	NOUN
admet-553	481	6	18	18	NUM
admet-553	481	7	(	(	PUNCT
admet-553	481	8	supplement	supplement	NOUN
admet-553	481	9	1	1	NUM
admet-553	481	10	)	)	PUNCT
admet-553	481	11	(	(	PUNCT
admet-553	481	12	2001	2001	NUM
admet-553	481	13	)	)	PUNCT
admet-553	481	14	11	11	NUM
admet-553	481	15	-	-	SYM
admet-553	481	16	15	15	NUM
admet-553	481	17	.	.	PUNCT
admet-553	482	1	f.	f.	PROPN
admet-553	482	2	tsopelas	tsopelas	PROPN
admet-553	482	3	,	,	PUNCT
admet-553	482	4	c.	c.	PROPN
admet-553	482	5	stergiopoulos	stergiopoulos	PROPN
admet-553	482	6	,	,	PUNCT
admet-553	482	7	a.	a.	NOUN
admet-553	482	8	tsantili	tsantili	NOUN
admet-553	482	9	-	-	PUNCT
admet-553	482	10	kakoulidou	kakoulidou	NOUN
admet-553	482	11	admet	admet	PROPN
admet-553	482	12	&	&	CCONJ
admet-553	482	13	dmpk	dmpk	PROPN
admet-553	482	14	6(3	6(3	PROPN
admet-553	482	15	)	)	PUNCT
admet-553	482	16	(	(	PUNCT
admet-553	482	17	2018	2018	NUM
admet-553	482	18	)	)	PUNCT
admet-553	482	19	225	225	NUM
admet-553	482	20	-	-	SYM
admet-553	482	21	241	241	NUM
admet-553	482	22	240	240	NUM
admet-553	482	23	[	[	X
admet-553	482	24	70	70	NUM
admet-553	482	25	]	]	X
admet-553	482	26	l.j	l.j	PROPN
admet-553	482	27	.	.	PROPN
admet-553	482	28	gordon	gordon	PROPN
admet-553	482	29	,	,	PUNCT
admet-553	482	30	m.	m.	NOUN
admet-553	482	31	allen	allen	PROPN
admet-553	482	32	,	,	PUNCT
admet-553	482	33	p.	p.	PROPN
admet-553	482	34	artursson	artursson	PROPN
admet-553	482	35	,	,	PUNCT
admet-553	482	36	m.m	m.m	PROPN
admet-553	482	37	.	.	PROPN
admet-553	482	38	hann	hann	PROPN
admet-553	482	39	,	,	PUNCT
admet-553	482	40	b.j	b.j	PROPN
admet-553	482	41	.	.	PROPN
admet-553	482	42	leavens	leaven	VERB
admet-553	482	43	,	,	PUNCT
admet-553	482	44	a.	a.	NOUN
admet-553	482	45	mateus	mateus	PROPN
admet-553	482	46	,	,	PUNCT
admet-553	482	47	s.	s.	PROPN
admet-553	482	48	readshaw	readshaw	PROPN
admet-553	482	49	,	,	PUNCT
admet-553	482	50	k.	k.	PROPN
admet-553	482	51	valko	valko	PROPN
admet-553	482	52	,	,	PUNCT
admet-553	482	53	g.j	g.j	PROPN
admet-553	482	54	.	.	PROPN
admet-553	482	55	wayne	wayne	PROPN
admet-553	482	56	,	,	PUNCT
admet-553	482	57	a.	a.	PROPN
admet-553	482	58	west	west	PROPN
admet-553	482	59	.	.	PUNCT
admet-553	483	1	direct	direct	ADJ
admet-553	483	2	measurement	measurement	NOUN
admet-553	483	3	of	of	ADP
admet-553	483	4	intracellular	intracellular	ADJ
admet-553	483	5	compound	compound	NOUN
admet-553	483	6	concentration	concentration	NOUN
admet-553	483	7	by	by	ADP
admet-553	483	8	rapidfire	rapidfire	NOUN
admet-553	483	9	mass	mass	PROPN
admet-553	483	10	spectrometry	spectrometry	NOUN
admet-553	483	11	offers	offer	VERB
admet-553	483	12	insights	insight	NOUN
admet-553	483	13	into	into	ADP
admet-553	483	14	cell	cell	NOUN
admet-553	483	15	permeability	permeability	NOUN
admet-553	483	16	.	.	PUNCT
admet-553	484	1	journal	journal	NOUN
admet-553	484	2	of	of	ADP
admet-553	484	3	biomolecular	biomolecular	ADJ
admet-553	484	4	screening	screen	VERB
admet-553	484	5	21	21	NUM
admet-553	484	6	(	(	PUNCT
admet-553	484	7	2016	2016	NUM
admet-553	484	8	)	)	PUNCT
admet-553	484	9	156	156	NUM
admet-553	484	10	-	-	SYM
admet-553	484	11	164	164	NUM
admet-553	484	12	.	.	PUNCT
admet-553	485	1	[	[	X
admet-553	485	2	71	71	NUM
admet-553	485	3	]	]	X
admet-553	485	4	k.r	k.r	PROPN
admet-553	485	5	.	.	PROPN
admet-553	485	6	hoover	hoover	PROPN
admet-553	485	7	,	,	PUNCT
admet-553	485	8	w.e	w.e	PROPN
admet-553	485	9	.	.	PROPN
admet-553	485	10	acree	acree	PROPN
admet-553	485	11	,	,	PUNCT
admet-553	485	12	m.h	m.h	PROPN
admet-553	485	13	.	.	PROPN
admet-553	485	14	abraham	abraham	PROPN
admet-553	485	15	.	.	PUNCT
admet-553	486	1	chemical	chemical	NOUN
admet-553	486	2	toxicity	toxicity	NOUN
admet-553	486	3	correlations	correlation	NOUN
admet-553	486	4	for	for	ADP
admet-553	486	5	several	several	ADJ
admet-553	486	6	fish	fish	NOUN
admet-553	486	7	species	specie	NOUN
admet-553	486	8	based	base	VERB
admet-553	486	9	on	on	ADP
admet-553	486	10	the	the	DET
admet-553	486	11	abraham	abraham	PROPN
admet-553	486	12	solvation	solvation	PROPN
admet-553	486	13	parameter	parameter	PROPN
admet-553	486	14	model	model	PROPN
admet-553	486	15	.	.	PUNCT
admet-553	487	1	chemical	chemical	ADJ
admet-553	487	2	research	research	NOUN
admet-553	487	3	in	in	ADP
admet-553	487	4	toxicology	toxicology	NOUN
admet-553	487	5	18	18	NUM
admet-553	487	6	(	(	PUNCT
admet-553	487	7	2005	2005	NUM
admet-553	487	8	)	)	PUNCT
admet-553	487	9	1497	1497	NUM
admet-553	487	10	-	-	SYM
admet-553	487	11	1505	1505	NUM
admet-553	487	12	.	.	PUNCT
admet-553	488	1	[	[	X
admet-553	488	2	72	72	NUM
admet-553	488	3	]	]	SYM
admet-553	488	4	regulation	regulation	NOUN
admet-553	488	5	(	(	PUNCT
admet-553	488	6	ec	ec	PROPN
admet-553	488	7	)	)	PUNCT
admet-553	488	8	no	no	PRON
admet-553	488	9	1907/	1907/	NUM
admet-553	488	10	2006	2006	NUM
admet-553	488	11	of	of	ADP
admet-553	488	12	the	the	DET
admet-553	488	13	european	european	ADJ
admet-553	488	14	parliament	parliament	NOUN
admet-553	488	15	and	and	CCONJ
admet-553	488	16	the	the	DET
admet-553	488	17	council	council	NOUN
admet-553	488	18	of	of	ADP
admet-553	488	19	18	18	NUM
admet-553	488	20	december	december	PROPN
admet-553	488	21	2006	2006	NUM
admet-553	488	22	concerning	concern	VERB
admet-553	488	23	the	the	DET
admet-553	488	24	registration	registration	NOUN
admet-553	488	25	,	,	PUNCT
admet-553	488	26	evaluation	evaluation	NOUN
admet-553	488	27	,	,	PUNCT
admet-553	488	28	authorisation	authorisation	NOUN
admet-553	488	29	and	and	CCONJ
admet-553	488	30	restriction	restriction	NOUN
admet-553	488	31	of	of	ADP
admet-553	488	32	chemicals	chemical	NOUN
admet-553	488	33	(	(	PUNCT
admet-553	488	34	reach	reach	NOUN
admet-553	488	35	)	)	PUNCT
admet-553	488	36	.	.	PUNCT
admet-553	489	1	available	available	ADJ
admet-553	489	2	at	at	ADP
admet-553	489	3	http://eur-lex.europa.eu/legal-content/en/txt/?uri=celex:32006r1907	http://eur-lex.europa.eu/legal-content/en/txt/?uri=celex:32006r1907	PROPN
admet-553	489	4	(	(	PUNCT
admet-553	489	5	retrieved	retrieve	VERB
admet-553	489	6	at	at	ADP
admet-553	489	7	53	53	NUM
admet-553	489	8	-	-	SYM
admet-553	489	9	2018	2018	NUM
admet-553	489	10	)	)	PUNCT
admet-553	489	11	.	.	PUNCT
admet-553	490	1	[	[	X
admet-553	490	2	73	73	NUM
admet-553	490	3	]	]	X
admet-553	490	4	european	european	PROPN
admet-553	490	5	commission	commission	PROPN
admet-553	490	6	,	,	PUNCT
admet-553	490	7	joint	joint	ADJ
admet-553	490	8	research	research	NOUN
admet-553	490	9	centre	centre	NOUN
admet-553	490	10	,	,	PUNCT
admet-553	490	11	european	european	PROPN
admet-553	490	12	union	union	PROPN
admet-553	490	13	reference	reference	NOUN
admet-553	490	14	laboratory	laboratory	NOUN
admet-553	490	15	for	for	ADP
admet-553	490	16	alternatives	alternative	NOUN
admet-553	490	17	to	to	ADP
admet-553	490	18	animal	animal	NOUN
admet-553	490	19	testing	testing	NOUN
admet-553	490	20	,	,	PUNCT
admet-553	490	21	2018	2018	NUM
admet-553	490	22	.	.	PUNCT
admet-553	491	1	retrieved	retrieve	VERB
admet-553	491	2	from	from	ADP
admet-553	491	3	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatoryacceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatoryacceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation	NOUN
admet-553	491	4	on	on	ADP
admet-553	491	5	23	23	NUM
admet-553	491	6	-	-	SYM
admet-553	491	7	4	4	NUM
admet-553	491	8	-	-	NUM
admet-553	491	9	2018	2018	NUM
admet-553	491	10	.	.	PUNCT
admet-553	492	1	[	[	X
admet-553	492	2	74	74	NUM
admet-553	492	3	]	]	X
admet-553	492	4	m.h	m.h	PROPN
admet-553	492	5	.	.	PROPN
admet-553	492	6	abraham	abraham	PROPN
admet-553	492	7	,	,	PUNCT
admet-553	492	8	c.	c.	PROPN
admet-553	492	9	rafols	rafol	NOUN
admet-553	492	10	.	.	PUNCT
admet-553	493	1	factors	factor	NOUN
admet-553	493	2	that	that	PRON
admet-553	493	3	influence	influence	VERB
admet-553	493	4	tadpole	tadpole	NOUN
admet-553	493	5	narcosis	narcosis	NOUN
admet-553	493	6	.	.	PUNCT
admet-553	494	1	an	an	DET
admet-553	494	2	lfer	lfer	NOUN
admet-553	494	3	analysis	analysis	NOUN
admet-553	494	4	.	.	PUNCT
admet-553	495	1	journal	journal	NOUN
admet-553	495	2	of	of	ADP
admet-553	495	3	the	the	DET
admet-553	495	4	chemical	chemical	NOUN
admet-553	495	5	society	society	NOUN
admet-553	495	6	,	,	PUNCT
admet-553	495	7	perkin	perkin	PROPN
admet-553	495	8	transactions	transaction	VERB
admet-553	495	9	2	2	NUM
admet-553	495	10	10	10	NUM
admet-553	495	11	(	(	PUNCT
admet-553	495	12	1995	1995	NUM
admet-553	495	13	)	)	PUNCT
admet-553	495	14	1843	1843	NUM
admet-553	495	15	-	-	SYM
admet-553	495	16	1851	1851	NUM
admet-553	495	17	.	.	PUNCT
admet-553	496	1	[	[	X
admet-553	496	2	75	75	NUM
admet-553	496	3	]	]	SYM
admet-553	496	4	k.r.bowen	k.r.bowen	PROPN
admet-553	496	5	,	,	PUNCT
admet-553	496	6	k.b	k.b	PROPN
admet-553	496	7	.	.	PROPN
admet-553	496	8	flanagan	flanagan	PROPN
admet-553	496	9	,	,	PUNCT
admet-553	496	10	w.e	w.e	PROPN
admet-553	496	11	.	.	PROPN
admet-553	496	12	acree	acree	PROPN
admet-553	496	13	,	,	PUNCT
admet-553	496	14	m.h	m.h	PROPN
admet-553	496	15	.	.	PROPN
admet-553	496	16	abraham	abraham	PROPN
admet-553	496	17	,	,	PUNCT
admet-553	496	18	c.	c.	PROPN
admet-553	496	19	rafols	rafol	NOUN
admet-553	496	20	.	.	PUNCT
admet-553	497	1	correlation	correlation	NOUN
admet-553	497	2	of	of	ADP
admet-553	497	3	the	the	DET
admet-553	497	4	toxicity	toxicity	NOUN
admet-553	497	5	of	of	ADP
admet-553	497	6	organic	organic	ADJ
admet-553	497	7	compounds	compound	NOUN
admet-553	497	8	to	to	ADP
admet-553	497	9	tadpoles	tadpole	NOUN
admet-553	497	10	using	use	VERB
admet-553	497	11	the	the	DET
admet-553	497	12	abraham	abraham	PROPN
admet-553	497	13	model	model	PROPN
admet-553	497	14	.	.	PUNCT
admet-553	498	1	the	the	DET
admet-553	498	2	science	science	NOUN
admet-553	498	3	of	of	ADP
admet-553	498	4	the	the	DET
admet-553	498	5	total	total	ADJ
admet-553	498	6	environment	environment	NOUN
admet-553	498	7	371	371	NUM
admet-553	498	8	(	(	PUNCT
admet-553	498	9	2006	2006	NUM
admet-553	498	10	)	)	PUNCT
admet-553	498	11	99	99	NUM
admet-553	498	12	-	-	SYM
admet-553	498	13	109	109	NUM
admet-553	498	14	.	.	PUNCT
admet-553	499	1	[	[	X
admet-553	499	2	76	76	NUM
admet-553	499	3	]	]	X
admet-553	499	4	h.	h.	PROPN
admet-553	499	5	laue	laue	PROPN
admet-553	499	6	,	,	PUNCT
admet-553	499	7	h.	h.	PROPN
admet-553	499	8	gfeller	gfeller	NOUN
admet-553	499	9	,	,	PUNCT
admet-553	499	10	k.j	k.j	PROPN
admet-553	499	11	.	.	PROPN
admet-553	499	12	jenner	jenner	PROPN
admet-553	499	13	,	,	PUNCT
admet-553	499	14	j.w	j.w	PROPN
admet-553	499	15	.	.	PROPN
admet-553	499	16	nichols	nichols	PROPN
admet-553	499	17	,	,	PUNCT
admet-553	499	18	s.	s.	PROPN
admet-553	499	19	kern	kern	PROPN
admet-553	499	20	,	,	PUNCT
admet-553	499	21	a.	a.	PROPN
admet-553	499	22	natsch	natsch	PROPN
admet-553	499	23	.	.	PUNCT
admet-553	500	1	predicting	predict	VERB
admet-553	500	2	the	the	DET
admet-553	500	3	bioconcentration	bioconcentration	NOUN
admet-553	500	4	of	of	ADP
admet-553	500	5	fragrance	fragrance	NOUN
admet-553	500	6	ingredients	ingredient	NOUN
admet-553	500	7	by	by	ADP
admet-553	500	8	rainbow	rainbow	NOUN
admet-553	500	9	trout	trout	NOUN
admet-553	500	10	using	use	VERB
admet-553	500	11	measured	measured	ADJ
admet-553	500	12	rates	rate	NOUN
admet-553	500	13	of	of	ADP
admet-553	500	14	in	in	ADP
admet-553	500	15	vitro	vitro	X
admet-553	500	16	intrinsic	intrinsic	ADJ
admet-553	500	17	clearance	clearance	NOUN
admet-553	500	18	.	.	PUNCT
admet-553	501	1	environmental	environmental	ADJ
admet-553	501	2	science	science	NOUN
admet-553	501	3	and	and	CCONJ
admet-553	501	4	technology	technology	NOUN
admet-553	501	5	48	48	NUM
admet-553	501	6	(	(	PUNCT
admet-553	501	7	2014	2014	NUM
admet-553	501	8	)	)	PUNCT
admet-553	501	9	9486	9486	NUM
admet-553	501	10	-	-	SYM
admet-553	501	11	9495	9495	NUM
admet-553	501	12	.	.	PUNCT
admet-553	502	1	[	[	X
admet-553	502	2	77	77	NUM
admet-553	502	3	]	]	X
admet-553	502	4	n.	n.	NOUN
admet-553	502	5	kluver	kluver	PROPN
admet-553	502	6	,	,	PUNCT
admet-553	502	7	c.	c.	PROPN
admet-553	502	8	vogs	vog	VERB
admet-553	502	9	,	,	PUNCT
admet-553	502	10	r.	r.	PROPN
admet-553	502	11	altenburger	altenburger	PROPN
admet-553	502	12	,	,	PUNCT
admet-553	502	13	b.i	b.i	PROPN
admet-553	502	14	.	.	PROPN
admet-553	502	15	escher	escher	PROPN
admet-553	502	16	,	,	PUNCT
admet-553	502	17	s.	s.	PROPN
admet-553	502	18	scholz	scholz	PROPN
admet-553	502	19	.	.	PUNCT
admet-553	503	1	development	development	NOUN
admet-553	503	2	of	of	ADP
admet-553	503	3	a	a	DET
admet-553	503	4	general	general	ADJ
admet-553	503	5	baseline	baseline	NOUN
admet-553	503	6	toxicity	toxicity	NOUN
admet-553	503	7	qsar	qsar	NOUN
admet-553	503	8	model	model	NOUN
admet-553	503	9	for	for	ADP
admet-553	503	10	the	the	DET
admet-553	503	11	fish	fish	NOUN
admet-553	503	12	embryo	embryo	NOUN
admet-553	503	13	acute	acute	NOUN
admet-553	503	14	toxicity	toxicity	NOUN
admet-553	503	15	test	test	NOUN
admet-553	503	16	.	.	PUNCT
admet-553	504	1	chemosphere	chemosphere	VERB
admet-553	504	2	164	164	NUM
admet-553	504	3	(	(	PUNCT
admet-553	504	4	2016	2016	NUM
admet-553	504	5	)	)	PUNCT
admet-553	504	6	164	164	NUM
admet-553	504	7	-	-	SYM
admet-553	504	8	173	173	NUM
admet-553	504	9	.	.	PUNCT
admet-553	505	1	[	[	X
admet-553	505	2	78	78	NUM
admet-553	505	3	]	]	PUNCT
admet-553	505	4	e.	e.	PROPN
admet-553	505	5	perales	perales	PROPN
admet-553	505	6	,	,	PUNCT
admet-553	505	7	j.i	j.i	PROPN
admet-553	505	8	.	.	PROPN
admet-553	505	9	garcia	garcia	PROPN
admet-553	505	10	,	,	PUNCT
admet-553	505	11	e.	e.	PROPN
admet-553	505	12	pires	pires	PROPN
admet-553	505	13	,	,	PUNCT
admet-553	505	14	l.	l.	PROPN
admet-553	505	15	aldea	aldea	PROPN
admet-553	505	16	,	,	PUNCT
admet-553	505	17	l.	l.	PROPN
admet-553	505	18	lomba	lomba	PROPN
admet-553	505	19	,	,	PUNCT
admet-553	505	20	b.	b.	PROPN
admet-553	505	21	giner	giner	PROPN
admet-553	505	22	.	.	PUNCT
admet-553	506	1	ecotoxicity	ecotoxicity	NOUN
admet-553	506	2	and	and	CCONJ
admet-553	506	3	qsar	qsar	NOUN
admet-553	506	4	studies	study	NOUN
admet-553	506	5	of	of	ADP
admet-553	506	6	glycerol	glycerol	NOUN
admet-553	506	7	ethers	ether	NOUN
admet-553	506	8	in	in	ADP
admet-553	506	9	daphnia	daphnia	PROPN
admet-553	506	10	magna	magna	PROPN
admet-553	506	11	.	.	PUNCT
admet-553	506	12	chemosphere	chemosphere	PROPN
admet-553	506	13	183	183	NUM
admet-553	506	14	(	(	PUNCT
admet-553	506	15	2017	2017	NUM
admet-553	506	16	)	)	PUNCT
admet-553	506	17	277	277	NUM
admet-553	506	18	-	-	PUNCT
admet-553	506	19	285	285	NUM
admet-553	506	20	.	.	PUNCT
admet-553	507	1	[	[	X
admet-553	507	2	79	79	NUM
admet-553	507	3	]	]	PUNCT
admet-553	507	4	s.	s.	PROPN
admet-553	507	5	bakire	bakire	PROPN
admet-553	507	6	,	,	PUNCT
admet-553	507	7	x.	x.	PROPN
admet-553	507	8	yang	yang	PROPN
admet-553	507	9	,	,	PUNCT
admet-553	507	10	g.	g.	PROPN
admet-553	507	11	ma	ma	PROPN
admet-553	507	12	,	,	PUNCT
admet-553	507	13	x.	x.	PROPN
admet-553	507	14	wei	wei	PROPN
admet-553	507	15	,	,	PUNCT
admet-553	507	16	h.	h.	PROPN
admet-553	507	17	yu	yu	PROPN
admet-553	507	18	,	,	PUNCT
admet-553	507	19	j.	j.	PROPN
admet-553	507	20	chen	chen	PROPN
admet-553	507	21	,	,	PUNCT
admet-553	507	22	h.	h.	PROPN
admet-553	507	23	lin	lin	PROPN
admet-553	507	24	.	.	PUNCT
admet-553	508	1	developing	develop	VERB
admet-553	508	2	predictive	predictive	ADJ
admet-553	508	3	models	model	NOUN
admet-553	508	4	for	for	ADP
admet-553	508	5	toxicity	toxicity	NOUN
admet-553	508	6	of	of	ADP
admet-553	508	7	organic	organic	ADJ
admet-553	508	8	chemicals	chemical	NOUN
admet-553	508	9	to	to	ADP
admet-553	508	10	green	green	ADJ
admet-553	508	11	algae	algae	NOUN
admet-553	508	12	based	base	VERB
admet-553	508	13	on	on	ADP
admet-553	508	14	mode	mode	NOUN
admet-553	508	15	of	of	ADP
admet-553	508	16	action	action	NOUN
admet-553	508	17	.	.	PUNCT
admet-553	509	1	chemosphere	chemosphere	PROPN
admet-553	509	2	190	190	NUM
admet-553	509	3	(	(	PUNCT
admet-553	509	4	2018	2018	NUM
admet-553	509	5	)	)	PUNCT
admet-553	509	6	463	463	NUM
admet-553	509	7	-	-	SYM
admet-553	509	8	470	470	NUM
admet-553	509	9	.	.	PUNCT
admet-553	510	1	[	[	X
admet-553	510	2	80	80	NUM
admet-553	510	3	]	]	PUNCT
admet-553	510	4	p.	p.	NOUN
admet-553	510	5	gramatica	gramatica	PROPN
admet-553	510	6	,	,	PUNCT
admet-553	510	7	e.	e.	PROPN
admet-553	510	8	papa	papa	PROPN
admet-553	510	9	,	,	PUNCT
admet-553	510	10	a.	a.	NOUN
admet-553	510	11	sangion	sangion	NOUN
admet-553	510	12	.	.	PUNCT
admet-553	511	1	qsar	qsar	PROPN
admet-553	511	2	modeling	modeling	NOUN
admet-553	511	3	of	of	ADP
admet-553	511	4	cumulative	cumulative	ADJ
admet-553	511	5	environmental	environmental	ADJ
admet-553	511	6	endpoints	endpoint	NOUN
admet-553	511	7	for	for	ADP
admet-553	511	8	the	the	DET
admet-553	511	9	prioritization	prioritization	NOUN
admet-553	511	10	of	of	ADP
admet-553	511	11	hazardous	hazardous	ADJ
admet-553	511	12	chemicals	chemical	NOUN
admet-553	511	13	.	.	PUNCT
admet-553	512	1	environmental	environmental	ADJ
admet-553	512	2	science	science	NOUN
admet-553	512	3	:	:	PUNCT
admet-553	512	4	processes	process	NOUN
admet-553	512	5	and	and	CCONJ
admet-553	512	6	impacts	impact	NOUN
admet-553	512	7	20	20	NUM
admet-553	512	8	(	(	PUNCT
admet-553	512	9	2018	2018	NUM
admet-553	512	10	)	)	PUNCT
admet-553	512	11	3847	3847	NUM
admet-553	512	12	.	.	PUNCT
admet-553	513	1	[	[	X
admet-553	513	2	81	81	NUM
admet-553	513	3	]	]	PUNCT
admet-553	513	4	j.	j.	PROPN
admet-553	513	5	he	he	PROPN
admet-553	513	6	,	,	PUNCT
admet-553	513	7	t.	t.	PROPN
admet-553	513	8	peng	peng	PROPN
admet-553	513	9	,	,	PUNCT
admet-553	513	10	x.	x.	PROPN
admet-553	513	11	yang	yang	PROPN
admet-553	513	12	,	,	PUNCT
admet-553	513	13	h.	h.	PROPN
admet-553	513	14	liu	liu	PROPN
admet-553	513	15	.	.	PUNCT
admet-553	514	1	development	development	NOUN
admet-553	514	2	of	of	ADP
admet-553	514	3	qsar	qsar	NOUN
admet-553	514	4	models	model	NOUN
admet-553	514	5	for	for	ADP
admet-553	514	6	predicting	predict	VERB
admet-553	514	7	the	the	DET
admet-553	514	8	binding	bind	VERB
admet-553	514	9	affinity	affinity	NOUN
admet-553	514	10	of	of	ADP
admet-553	514	11	endocrine	endocrine	NOUN
admet-553	514	12	disrupting	disrupt	VERB
admet-553	514	13	chemicals	chemical	NOUN
admet-553	514	14	to	to	ADP
admet-553	514	15	eight	eight	NUM
admet-553	514	16	fish	fish	NOUN
admet-553	514	17	estrogen	estrogen	NOUN
admet-553	514	18	receptor	receptor	NOUN
admet-553	514	19	.	.	PUNCT
admet-553	515	1	ecotoxicology	ecotoxicology	NOUN
admet-553	515	2	and	and	CCONJ
admet-553	515	3	environmental	environmental	ADJ
admet-553	515	4	safety	safety	NOUN
admet-553	515	5	148	148	NUM
admet-553	515	6	(	(	PUNCT
admet-553	515	7	2018	2018	NUM
admet-553	515	8	)	)	PUNCT
admet-553	515	9	211	211	NUM
admet-553	515	10	-	-	SYM
admet-553	515	11	219	219	NUM
admet-553	515	12	.	.	PUNCT
admet-553	516	1	[	[	X
admet-553	516	2	82	82	NUM
admet-553	516	3	]	]	X
admet-553	516	4	c.	c.	PROPN
admet-553	516	5	l.	l.	PROPN
admet-553	516	6	russom	russom	PROPN
admet-553	516	7	,	,	PUNCT
admet-553	516	8	s.p	s.p	PROPN
admet-553	516	9	.	.	PROPN
admet-553	516	10	bradbury	bradbury	PROPN
admet-553	516	11	,	,	PUNCT
admet-553	516	12	s.j	s.j	PROPN
admet-553	516	13	.	.	PROPN
admet-553	516	14	broderius	broderius	PROPN
admet-553	516	15	,	,	PUNCT
admet-553	516	16	d.e	d.e	PROPN
admet-553	516	17	.	.	PROPN
admet-553	516	18	hammermeister	hammermeister	PROPN
admet-553	516	19	,	,	PUNCT
admet-553	516	20	r.a	r.a	PROPN
admet-553	516	21	.	.	PROPN
admet-553	516	22	drummond	drummond	PROPN
admet-553	516	23	.	.	PUNCT
admet-553	516	24	predicting	predict	VERB
admet-553	516	25	modes	mode	NOUN
admet-553	516	26	of	of	ADP
admet-553	516	27	toxic	toxic	ADJ
admet-553	516	28	action	action	NOUN
admet-553	516	29	from	from	ADP
admet-553	516	30	chemical	chemical	ADJ
admet-553	516	31	structure	structure	NOUN
admet-553	516	32	:	:	PUNCT
admet-553	516	33	acute	acute	ADJ
admet-553	516	34	toxicity	toxicity	NOUN
admet-553	516	35	in	in	ADP
admet-553	516	36	the	the	DET
admet-553	516	37	fathead	fathead	NOUN
admet-553	516	38	minnow	minnow	NOUN
admet-553	516	39	(	(	PUNCT
admet-553	516	40	pimephales	pimephale	NOUN
admet-553	516	41	promelas	promela	NOUN
admet-553	516	42	)	)	PUNCT
admet-553	516	43	.	.	PUNCT
admet-553	517	1	environmental	environmental	ADJ
admet-553	517	2	toxicology	toxicology	NOUN
admet-553	517	3	and	and	CCONJ
admet-553	517	4	chemistry	chemistry	NOUN
admet-553	517	5	16	16	NUM
admet-553	517	6	(	(	PUNCT
admet-553	517	7	1997	1997	NUM
admet-553	517	8	)	)	PUNCT
admet-553	517	9	948	948	NUM
admet-553	517	10	-	-	SYM
admet-553	517	11	967	967	NUM
admet-553	517	12	.	.	PUNCT
admet-553	518	1	[	[	X
admet-553	518	2	83	83	NUM
admet-553	518	3	]	]	X
admet-553	518	4	u.s	u.s	PROPN
admet-553	518	5	.	.	PROPN
admet-553	518	6	,	,	PUNCT
admet-553	518	7	environmental	environmental	PROPN
admet-553	518	8	protection	protection	PROPN
admet-553	518	9	agency	agency	PROPN
admet-553	518	10	(	(	PUNCT
admet-553	518	11	epa	epa	PROPN
admet-553	518	12	)	)	PUNCT
admet-553	518	13	.	.	PUNCT
admet-553	519	1	estimation	estimation	NOUN
admet-553	519	2	program	program	NOUN
admet-553	519	3	interface	interface	NOUN
admet-553	519	4	(	(	PUNCT
admet-553	519	5	epi	epi	NOUN
admet-553	519	6	)	)	PUNCT
admet-553	519	7	suite	suite	NOUN
admet-553	519	8	,	,	PUNCT
admet-553	519	9	version	version	NOUN
admet-553	519	10	4.11	4.11	NUM
admet-553	519	11	.	.	PUNCT
admet-553	519	12	,	,	PUNCT
admet-553	519	13	2012	2012	NUM
admet-553	519	14	.	.	PUNCT
admet-553	520	1	u.s	u.s	PROPN
admet-553	520	2	.	.	PROPN
admet-553	520	3	environmental	environmental	PROPN
admet-553	520	4	protection	protection	PROPN
admet-553	520	5	agency	agency	PROPN
admet-553	520	6	,	,	PUNCT
admet-553	520	7	office	office	NOUN
admet-553	520	8	of	of	ADP
admet-553	520	9	pollution	pollution	NOUN
admet-553	520	10	,	,	PUNCT
admet-553	520	11	prevention	prevention	NOUN
admet-553	520	12	and	and	CCONJ
admet-553	520	13	toxics	toxic	NOUN
admet-553	520	14	:	:	PUNCT
admet-553	520	15	washington	washington	PROPN
admet-553	520	16	.	.	PUNCT
admet-553	521	1	available	available	ADJ
admet-553	521	2	at	at	ADP
admet-553	521	3	https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface	https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface	NOUN
admet-553	521	4	(	(	PUNCT
admet-553	521	5	retrieved	retrieve	VERB
admet-553	521	6	at	at	ADP
admet-553	521	7	21	21	NUM
admet-553	521	8	-	-	SYM
admet-553	521	9	4	4	NUM
admet-553	521	10	-	-	NUM
admet-553	521	11	2018	2018	NUM
admet-553	521	12	)	)	PUNCT
admet-553	521	13	.	.	PUNCT
admet-553	522	1	[	[	X
admet-553	522	2	84	84	NUM
admet-553	522	3	]	]	X
admet-553	522	4	w.m	w.m	PROPN
admet-553	522	5	.	.	PROPN
admet-553	522	6	meylan	meylan	PROPN
admet-553	522	7	,	,	PUNCT
admet-553	522	8	p.h	p.h	PROPN
admet-553	522	9	.	.	PROPN
admet-553	522	10	howard	howard	PROPN
admet-553	522	11	,	,	PUNCT
admet-553	522	12	r.s	r.s	PROPN
admet-553	522	13	.	.	PROPN
admet-553	522	14	boethling	boethling	PROPN
admet-553	522	15	,	,	PUNCT
admet-553	522	16	d.	d.	PROPN
admet-553	522	17	aronson	aronson	PROPN
admet-553	522	18	,	,	PUNCT
admet-553	522	19	h.	h.	PROPN
admet-553	522	20	printu	printu	PROPN
admet-553	522	21	,	,	PUNCT
admet-553	522	22	s.	s.	PROPN
admet-553	522	23	gouchie	gouchie	PROPN
admet-553	522	24	.	.	PUNCT
admet-553	523	1	improved	improve	VERB
admet-553	523	2	method	method	NOUN
admet-553	523	3	for	for	ADP
admet-553	523	4	estimating	estimate	VERB
admet-553	523	5	bioconcentration/	bioconcentration/	NUM
admet-553	523	6	bioaccumulation	bioaccumulation	NOUN
admet-553	523	7	factor	factor	NOUN
admet-553	523	8	from	from	ADP
admet-553	523	9	octanol/	octanol/	ADJ
admet-553	523	10	water	water	NOUN
admet-553	523	11	partition	partition	NOUN
admet-553	523	12	coefficient	coefficient	NOUN
admet-553	523	13	.	.	PUNCT
admet-553	524	1	environmental	environmental	ADJ
admet-553	524	2	toxicology	toxicology	NOUN
admet-553	524	3	and	and	CCONJ
admet-553	524	4	chemistry	chemistry	NOUN
admet-553	524	5	18	18	NUM
admet-553	524	6	(	(	PUNCT
admet-553	524	7	1999	1999	NUM
admet-553	524	8	)	)	PUNCT
admet-553	524	9	664	664	NUM
admet-553	524	10	-	-	SYM
admet-553	524	11	672	672	NUM
admet-553	524	12	.	.	PUNCT
admet-553	525	1	[	[	X
admet-553	525	2	85	85	NUM
admet-553	525	3	]	]	X
admet-553	525	4	l.	l.	PROPN
admet-553	525	5	escudergilabert	escudergilabert	PROPN
admet-553	525	6	,	,	PUNCT
admet-553	525	7	s.	s.	PROPN
admet-553	525	8	sagrado	sagrado	PROPN
admet-553	525	9	,	,	PUNCT
admet-553	525	10	r.m	r.m	PROPN
admet-553	525	11	.	.	PROPN
admet-553	525	12	villanuevacamanas	villanuevacamanas	PROPN
admet-553	525	13	,	,	PUNCT
admet-553	525	14	m.j	m.j	PROPN
admet-553	525	15	.	.	PROPN
admet-553	525	16	medinahernandez	medinahernandez	PROPN
admet-553	525	17	.	.	PUNCT
admet-553	526	1	quantitative	quantitative	ADJ
admet-553	526	2	retentionstructureactivity	retentionstructureactivity	NOUN
admet-553	526	3	relationship	relationship	NOUN
admet-553	526	4	studies	study	NOUN
admet-553	526	5	of	of	ADP
admet-553	526	6	local	local	ADJ
admet-553	526	7	anesthetics	anesthetic	NOUN
admet-553	526	8	by	by	ADP
admet-553	526	9	micellar	micellar	ADJ
admet-553	526	10	liquid	liquid	ADJ
admet-553	526	11	chromatography	chromatography	NOUN
admet-553	526	12	,	,	PUNCT
admet-553	526	13	analytical	analytical	ADJ
admet-553	526	14	chemistry	chemistry	NOUN
admet-553	526	15	70	70	NUM
admet-553	526	16	(	(	PUNCT
admet-553	526	17	1998	1998	NUM
admet-553	526	18	)	)	PUNCT
admet-553	526	19	28	28	NUM
admet-553	526	20	-	-	SYM
admet-553	526	21	34	34	NUM
admet-553	526	22	.	.	PUNCT
admet-553	527	1	[	[	X
admet-553	527	2	86	86	NUM
admet-553	527	3	]	]	X
admet-553	527	4	j.m	j.m	PROPN
admet-553	527	5	.	.	PROPN
admet-553	527	6	bermudezsaldana	bermudezsaldana	PROPN
admet-553	527	7	,	,	PUNCT
admet-553	527	8	l.	l.	PROPN
admet-553	527	9	escudergilabert	escudergilabert	PROPN
admet-553	527	10	,	,	PUNCT
admet-553	527	11	m.j	m.j	PROPN
admet-553	527	12	.	.	PROPN
admet-553	527	13	medinahernandez	medinahernandez	PROPN
admet-553	527	14	,	,	PUNCT
admet-553	527	15	r.m	r.m	PROPN
admet-553	527	16	.	.	PROPN
admet-553	527	17	villanuevacamanas	villanuevacamanas	PROPN
admet-553	527	18	,	,	PUNCT
admet-553	527	19	s.	s.	PROPN
admet-553	527	20	sagrado	sagrado	PROPN
admet-553	527	21	.	.	PUNCT
admet-553	528	1	modelling	model	VERB
admet-553	528	2	bioconcentration	bioconcentration	NOUN
admet-553	528	3	of	of	ADP
admet-553	528	4	pesticides	pesticide	NOUN
admet-553	528	5	in	in	ADP
admet-553	528	6	fish	fish	NOUN
admet-553	528	7	using	use	VERB
admet-553	528	8	biopartitioning	biopartitione	VERB
admet-553	528	9	micellar	micellar	ADJ
admet-553	528	10	chromatography	chromatography	NOUN
admet-553	528	11	.	.	PUNCT
admet-553	529	1	journal	journal	PROPN
admet-553	529	2	of	of	ADP
admet-553	529	3	chromatography	chromatography	NOUN
admet-553	529	4	a	a	DET
admet-553	529	5	1063	1063	NUM
admet-553	529	6	(	(	PUNCT
admet-553	529	7	2005	2005	NUM
admet-553	529	8	)	)	PUNCT
admet-553	529	9	153	153	NUM
admet-553	529	10	-	-	SYM
admet-553	529	11	160	160	NUM
admet-553	529	12	.	.	PUNCT
admet-553	530	1	http://eur-lex.europa.eu/legal-content/en/txt/?uri=celex:32006r1907	http://eur-lex.europa.eu/legal-content/en/txt/?uri=celex:32006r1907	PROPN
admet-553	530	2	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatory-acceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation%20on%2023-4-2018	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatory-acceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation%20on%2023-4-2018	VERB
admet-553	530	3	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatory-acceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation%20on%2023-4-2018	https://eurl-ecvam.jrc.ec.europa.eu/validation-regulatory-acceptance/environmental-toxicity-fate/environmental-toxicity-bioaccumulation%20on%2023-4-2018	PROPN
admet-553	530	4	https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface	https://www.epa.gov/tsca-screening-tools/epi-suitetm-estimation-program-interface	PROPN
admet-553	530	5	admet	admet	PROPN
admet-553	530	6	&	&	CCONJ
admet-553	530	7	dmpk	dmpk	PROPN
admet-553	530	8	6(3	6(3	PROPN
admet-553	530	9	)	)	PUNCT
admet-553	530	10	(	(	PUNCT
admet-553	530	11	2018	2018	NUM
admet-553	530	12	)	)	PUNCT
admet-553	530	13	225	225	NUM
admet-553	530	14	-	-	SYM
admet-553	530	15	241	241	NUM
admet-553	530	16	iam	iam	PROPN
admet-553	530	17	chromatography	chromatography	NOUN
admet-553	530	18	in	in	ADP
admet-553	530	19	medicinal	medicinal	ADJ
admet-553	530	20	chemistry	chemistry	NOUN
admet-553	530	21	and	and	CCONJ
admet-553	530	22	environment	environment	NOUN
admet-553	530	23	doi	doi	PROPN
admet-553	530	24	:	:	PUNCT
admet-553	530	25	10.5599	10.5599	NUM
admet-553	530	26	/	/	SYM
admet-553	530	27	admet.553	admet.553	NOUN
admet-553	530	28	241	241	NUM
admet-553	530	29	[	[	X
admet-553	530	30	87	87	NUM
admet-553	530	31	]	]	SYM
admet-553	530	32	c	c	PROPN
admet-553	530	33	-	-	PUNCT
admet-553	530	34	r.	r.	PROPN
admet-553	530	35	yin	yin	PROPN
admet-553	530	36	,	,	PUNCT
admet-553	530	37	l	l	PROPN
admet-553	530	38	-	-	PROPN
admet-553	530	39	y.	y.	PROPN
admet-553	530	40	ma	ma	PROPN
admet-553	530	41	,	,	PUNCT
admet-553	530	42	j	j	PROPN
admet-553	530	43	-	-	PROPN
admet-553	530	44	g.	g.	PROPN
admet-553	530	45	huang	huang	PROPN
admet-553	530	46	,	,	PUNCT
admet-553	530	47	l.	l.	PROPN
admet-553	530	48	xu	xu	PROPN
admet-553	530	49	,	,	PUNCT
admet-553	530	50	z	z	PROPN
admet-553	530	51	-	-	PUNCT
admet-553	530	52	g.	g.	PROPN
admet-553	530	53	shi	shi	PROPN
admet-553	530	54	.	.	PUNCT
admet-553	531	1	fast	fast	ADJ
admet-553	531	2	profiling	profiling	NOUN
admet-553	531	3	ecotoxicity	ecotoxicity	NOUN
admet-553	531	4	and	and	CCONJ
admet-553	531	5	skin	skin	NOUN
admet-553	531	6	permeability	permeability	NOUN
admet-553	531	7	of	of	ADP
admet-553	531	8	benzophenone	benzophenone	NOUN
admet-553	531	9	ultraviolet	ultraviolet	NOUN
admet-553	531	10	filters	filter	NOUN
admet-553	531	11	using	use	VERB
admet-553	531	12	biopartitioning	biopartitione	VERB
admet-553	531	13	micellar	micellar	ADJ
admet-553	531	14	chromatography	chromatography	NOUN
admet-553	531	15	based	base	VERB
admet-553	531	16	on	on	ADP
admet-553	531	17	penetrable	penetrable	ADJ
admet-553	531	18	silica	silica	NOUN
admet-553	531	19	spheres	sphere	NOUN
admet-553	531	20	.	.	PUNCT
admet-553	532	1	analytica	analytica	PROPN
admet-553	532	2	chimica	chimica	PROPN
admet-553	532	3	acta	acta	PROPN
admet-553	532	4	804	804	NUM
admet-553	532	5	(	(	PUNCT
admet-553	532	6	2013	2013	NUM
admet-553	532	7	)	)	PUNCT
admet-553	532	8	321	321	NUM
admet-553	532	9	-	-	SYM
admet-553	532	10	327	327	NUM
admet-553	532	11	.	.	PUNCT
admet-553	533	1	[	[	X
admet-553	533	2	88	88	NUM
admet-553	533	3	]	]	X
admet-553	533	4	j.m	j.m	PROPN
admet-553	533	5	.	.	PROPN
admet-553	533	6	bermudezsaldana	bermudezsaldana	PROPN
admet-553	533	7	,	,	PUNCT
admet-553	533	8	l.	l.	PROPN
admet-553	533	9	escudergilabert	escudergilabert	PROPN
admet-553	533	10	,	,	PUNCT
admet-553	533	11	m.j	m.j	PROPN
admet-553	533	12	.	.	PROPN
admet-553	533	13	medinahernandez	medinahernandez	PROPN
admet-553	533	14	,	,	PUNCT
admet-553	533	15	r.m	r.m	PROPN
admet-553	533	16	.	.	PROPN
admet-553	533	17	villanuevacamanas	villanuevacamanas	PROPN
admet-553	533	18	,	,	PUNCT
admet-553	533	19	s.	s.	PROPN
admet-553	533	20	sagrado	sagrado	PROPN
admet-553	533	21	.	.	PUNCT
admet-553	534	1	modelling	model	VERB
admet-553	534	2	bioconcentration	bioconcentration	NOUN
admet-553	534	3	of	of	ADP
admet-553	534	4	pesticides	pesticide	NOUN
admet-553	534	5	in	in	ADP
admet-553	534	6	fish	fish	NOUN
admet-553	534	7	using	use	VERB
admet-553	534	8	biopartitioning	biopartitione	VERB
admet-553	534	9	micellar	micellar	ADJ
admet-553	534	10	chromatography	chromatography	NOUN
admet-553	534	11	.	.	PUNCT
admet-553	535	1	journal	journal	PROPN
admet-553	535	2	of	of	ADP
admet-553	535	3	chromatography	chromatography	PROPN
admet-553	535	4	b	b	PROPN
admet-553	535	5	852	852	NUM
admet-553	535	6	(	(	PUNCT
admet-553	535	7	2007	2007	NUM
admet-553	535	8	)	)	PUNCT
admet-553	535	9	353	353	NUM
admet-553	535	10	-	-	SYM
admet-553	535	11	361	361	NUM
admet-553	535	12	.	.	PUNCT
admet-553	536	1	[	[	X
admet-553	536	2	89	89	NUM
admet-553	536	3	]	]	X
admet-553	536	4	p.	p.	NOUN
admet-553	536	5	stepnowski	stepnowski	PROPN
admet-553	536	6	,	,	PUNCT
admet-553	536	7	p.	p.	PROPN
admet-553	536	8	storoniak	storoniak	PROPN
admet-553	536	9	.	.	PUNCT
admet-553	537	1	lipophilicity	lipophilicity	PROPN
admet-553	537	2	and	and	CCONJ
admet-553	537	3	metabolic	metabolic	NOUN
admet-553	537	4	route	route	NOUN
admet-553	537	5	prediction	prediction	NOUN
admet-553	537	6	of	of	ADP
admet-553	537	7	imidazolium	imidazolium	NOUN
admet-553	537	8	ionic	ionic	ADJ
admet-553	537	9	liquids	liquid	NOUN
admet-553	537	10	.	.	PUNCT
admet-553	538	1	environmental	environmental	ADJ
admet-553	538	2	science	science	NOUN
admet-553	538	3	and	and	CCONJ
admet-553	538	4	pollution	pollution	NOUN
admet-553	538	5	research	research	NOUN
admet-553	538	6	12	12	NUM
admet-553	538	7	(	(	PUNCT
admet-553	538	8	2005	2005	NUM
admet-553	538	9	)	)	PUNCT
admet-553	538	10	199	199	NUM
admet-553	538	11	-	-	SYM
admet-553	538	12	204	204	NUM
admet-553	538	13	.	.	PUNCT
admet-553	539	1	[	[	X
admet-553	539	2	90	90	NUM
admet-553	539	3	]	]	PUNCT
admet-553	539	4	m.	m.	NOUN
admet-553	539	5	janicka	janicka	PROPN
admet-553	539	6	.	.	PUNCT
admet-553	540	1	correlations	correlation	NOUN
admet-553	540	2	between	between	ADP
admet-553	540	3	chromatographic	chromatographic	ADJ
admet-553	540	4	parameters	parameter	NOUN
admet-553	540	5	and	and	CCONJ
admet-553	540	6	bioactivity	bioactivity	NOUN
admet-553	540	7	predictors	predictor	NOUN
admet-553	540	8	of	of	ADP
admet-553	540	9	potential	potential	ADJ
admet-553	540	10	herbicides	herbicide	NOUN
admet-553	540	11	.	.	PUNCT
admet-553	541	1	journal	journal	NOUN
admet-553	541	2	of	of	ADP
admet-553	541	3	chromatographic	chromatographic	ADJ
admet-553	541	4	science	science	NOUN
admet-553	541	5	52	52	NUM
admet-553	541	6	(	(	PUNCT
admet-553	541	7	2014	2014	NUM
admet-553	541	8	)	)	PUNCT
admet-553	541	9	676	676	NUM
admet-553	541	10	-	-	SYM
admet-553	541	11	684	684	NUM
admet-553	541	12	.	.	PUNCT
admet-553	542	1	[	[	X
admet-553	542	2	91	91	NUM
admet-553	542	3	]	]	X
admet-553	542	4	cimpean	cimpean	PROPN
admet-553	542	5	d.m	d.m	PROPN
admet-553	542	6	.	.	PROPN
admet-553	542	7	,	,	PUNCT
admet-553	542	8	poole	poole	PROPN
admet-553	542	9	c.f	c.f	PROPN
admet-553	542	10	.	.	PUNCT
admet-553	542	11	systematic	systematic	ADJ
admet-553	542	12	search	search	NOUN
admet-553	542	13	for	for	ADP
admet-553	542	14	surrogate	surrogate	ADJ
admet-553	542	15	chromatographic	chromatographic	ADJ
admet-553	542	16	models	model	NOUN
admet-553	542	17	of	of	ADP
admet-553	542	18	biopartitioning	biopartitione	VERB
admet-553	542	19	processes	process	NOUN
admet-553	542	20	.	.	PUNCT
admet-553	543	1	analyst	analyst	NOUN
admet-553	543	2	127	127	NUM
admet-553	543	3	(	(	PUNCT
admet-553	543	4	2002	2002	NUM
admet-553	543	5	)	)	PUNCT
admet-553	543	6	724	724	NUM
admet-553	543	7	-	-	SYM
admet-553	543	8	729	729	NUM
admet-553	543	9	.	.	PUNCT
admet-553	544	1	[	[	X
admet-553	544	2	92	92	NUM
admet-553	544	3	]	]	PUNCT
admet-553	544	4	m.	m.	NOUN
admet-553	544	5	hidalgorodriguez	hidalgorodriguez	NOUN
admet-553	544	6	,	,	PUNCT
admet-553	544	7	e.	e.	PROPN
admet-553	544	8	fuguet	fuguet	PROPN
admet-553	544	9	,	,	PUNCT
admet-553	544	10	c.	c.	PROPN
admet-553	544	11	rafols	rafols	PROPN
admet-553	544	12	,	,	PUNCT
admet-553	544	13	m.	m.	NOUN
admet-553	544	14	roses	rose	NOUN
admet-553	544	15	.	.	PUNCT
admet-553	545	1	modelling	model	VERB
admet-553	545	2	nonspecific	nonspecific	ADJ
admet-553	545	3	toxicity	toxicity	NOUN
admet-553	545	4	of	of	ADP
admet-553	545	5	organic	organic	ADJ
admet-553	545	6	compounds	compound	NOUN
admet-553	545	7	to	to	ADP
admet-553	545	8	the	the	DET
admet-553	545	9	fathead	fathead	NOUN
admet-553	545	10	minnow	minnow	NOUN
admet-553	545	11	fish	fish	NOUN
admet-553	545	12	by	by	ADP
admet-553	545	13	means	mean	NOUN
admet-553	545	14	of	of	ADP
admet-553	545	15	chromatographic	chromatographic	ADJ
admet-553	545	16	systems	system	NOUN
admet-553	545	17	.	.	PUNCT
admet-553	546	1	analytical	analytical	ADJ
admet-553	546	2	chemistry	chemistry	NOUN
admet-553	546	3	84	84	NUM
admet-553	546	4	(	(	PUNCT
admet-553	546	5	2012	2012	NUM
admet-553	546	6	)	)	PUNCT
admet-553	546	7	3446	3446	NUM
admet-553	546	8	-	-	SYM
admet-553	546	9	3452	3452	NUM
admet-553	546	10	.	.	PUNCT
admet-553	547	1	[	[	X
admet-553	547	2	93	93	NUM
admet-553	547	3	]	]	PUNCT
admet-553	547	4	m.	m.	NOUN
admet-553	547	5	hidalgorodriguez	hidalgorodriguez	PROPN
admet-553	547	6	,	,	PUNCT
admet-553	547	7	e.	e.	PROPN
admet-553	547	8	fuguet	fuguet	PROPN
admet-553	547	9	,	,	PUNCT
admet-553	547	10	c.	c.	PROPN
admet-553	547	11	rafols	rafols	PROPN
admet-553	547	12	,	,	PUNCT
admet-553	547	13	m.	m.	NOUN
admet-553	547	14	roses	rose	NOUN
admet-553	547	15	.	.	PUNCT
admet-553	548	1	performance	performance	NOUN
admet-553	548	2	of	of	ADP
admet-553	548	3	chromatographic	chromatographic	ADJ
admet-553	548	4	systems	system	NOUN
admet-553	548	5	to	to	PART
admet-553	548	6	model	model	VERB
admet-553	548	7	soilwater	soilwater	PROPN
admet-553	548	8	sorption	sorption	NOUN
admet-553	548	9	.	.	PUNCT
admet-553	549	1	journal	journal	PROPN
admet-553	549	2	of	of	ADP
admet-553	549	3	chromatography	chromatography	NOUN
admet-553	549	4	a	a	DET
admet-553	549	5	1252	1252	NUM
admet-553	549	6	(	(	PUNCT
admet-553	549	7	2012	2012	NUM
admet-553	549	8	)	)	PUNCT
admet-553	549	9	136	136	NUM
admet-553	549	10	-	-	SYM
admet-553	549	11	145	145	NUM
admet-553	549	12	.	.	PUNCT
admet-553	550	1	[	[	X
admet-553	550	2	94	94	NUM
admet-553	550	3	]	]	X
admet-553	550	4	a.	a.	NOUN
admet-553	550	5	fernandezpumarega	fernandezpumarega	PROPN
admet-553	550	6	,	,	PUNCT
admet-553	550	7	s.	s.	PROPN
admet-553	550	8	amezqueta	amezqueta	PROPN
admet-553	550	9	,	,	PUNCT
admet-553	550	10	e.	e.	PROPN
admet-553	550	11	fuguet	fuguet	PROPN
admet-553	550	12	,	,	PUNCT
admet-553	550	13	m.	m.	NOUN
admet-553	550	14	roses	rose	NOUN
admet-553	550	15	.	.	PUNCT
admet-553	551	1	tadpole	tadpole	NOUN
admet-553	551	2	toxicity	toxicity	NOUN
admet-553	551	3	prediction	prediction	NOUN
admet-553	551	4	using	use	VERB
admet-553	551	5	chromatographic	chromatographic	ADJ
admet-553	551	6	systems	system	NOUN
admet-553	551	7	.	.	PUNCT
admet-553	552	1	journal	journal	PROPN
admet-553	552	2	of	of	ADP
admet-553	552	3	chromatography	chromatography	NOUN
admet-553	552	4	a	a	DET
admet-553	552	5	1418	1418	NUM
admet-553	552	6	(	(	PUNCT
admet-553	552	7	2015	2015	NUM
admet-553	552	8	)	)	PUNCT
admet-553	552	9	167	167	NUM
admet-553	552	10	-	-	SYM
admet-553	552	11	176	176	NUM
admet-553	552	12	.	.	PUNCT
admet-553	553	1	[	[	X
admet-553	553	2	95	95	NUM
admet-553	553	3	]	]	X
admet-553	553	4	f.	f.	PROPN
admet-553	553	5	grisoni	grisoni	PROPN
admet-553	553	6	,	,	PUNCT
admet-553	553	7	v.	v.	PROPN
admet-553	553	8	consonni	consonni	PROPN
admet-553	553	9	,	,	PUNCT
admet-553	553	10	s.	s.	PROPN
admet-553	553	11	villa	villa	PROPN
admet-553	553	12	,	,	PUNCT
admet-553	553	13	m.	m.	NOUN
admet-553	553	14	vighi	vighi	PROPN
admet-553	553	15	,	,	PUNCT
admet-553	553	16	r.	r.	PROPN
admet-553	553	17	todeschini	todeschini	PROPN
admet-553	553	18	.	.	PUNCT
admet-553	554	1	qsar	qsar	NOUN
admet-553	554	2	models	model	NOUN
admet-553	554	3	for	for	ADP
admet-553	554	4	bioconcentration	bioconcentration	NOUN
admet-553	554	5	:	:	PUNCT
admet-553	554	6	is	be	AUX
admet-553	554	7	the	the	DET
admet-553	554	8	increase	increase	NOUN
admet-553	554	9	in	in	ADP
admet-553	554	10	the	the	DET
admet-553	554	11	complexity	complexity	NOUN
admet-553	554	12	justified	justify	VERB
admet-553	554	13	by	by	ADP
admet-553	554	14	more	more	ADJ
admet-553	554	15	accurate	accurate	ADJ
admet-553	554	16	predictions	prediction	NOUN
admet-553	554	17	?	?	PUNCT
admet-553	555	1	chemosphere	chemosphere	VERB
admet-553	555	2	127	127	NUM
admet-553	555	3	(	(	PUNCT
admet-553	555	4	2015	2015	NUM
admet-553	555	5	)	)	PUNCT
admet-553	555	6	171	171	NUM
admet-553	555	7	-	-	SYM
admet-553	555	8	179	179	NUM
admet-553	555	9	.	.	PUNCT
admet-553	556	1	[	[	X
admet-553	556	2	96	96	NUM
admet-553	556	3	]	]	X
admet-553	556	4	g.	g.	PROPN
admet-553	556	5	russo	russo	PROPN
admet-553	556	6	,	,	PUNCT
admet-553	556	7	a.	a.	NOUN
admet-553	556	8	capuozzo	capuozzo	PROPN
admet-553	556	9	,	,	PUNCT
admet-553	556	10	f.	f.	PROPN
admet-553	556	11	barbato	barbato	PROPN
admet-553	556	12	,	,	PUNCT
admet-553	556	13	c.	c.	NOUN
admet-553	556	14	irace	irace	NOUN
admet-553	556	15	,	,	PUNCT
admet-553	556	16	r.	r.	PROPN
admet-553	556	17	santamaria	santamaria	PROPN
admet-553	556	18	,	,	PUNCT
admet-553	556	19	l.	l.	PROPN
admet-553	556	20	grumetto	grumetto	PROPN
admet-553	556	21	.	.	PUNCT
admet-553	557	1	cytotoxicity	cytotoxicity	NOUN
admet-553	557	2	of	of	ADP
admet-553	557	3	seven	seven	NUM
admet-553	557	4	bisphenol	bisphenol	NOUN
admet-553	557	5	analogues	analogue	NOUN
admet-553	557	6	compared	compare	VERB
admet-553	557	7	to	to	PART
admet-553	557	8	bisphenol	bisphenol	VERB
admet-553	557	9	a	a	PRON
admet-553	557	10	and	and	CCONJ
admet-553	557	11	relationships	relationship	NOUN
admet-553	557	12	with	with	ADP
admet-553	557	13	membrane	membrane	NOUN
admet-553	557	14	affinity	affinity	NOUN
admet-553	557	15	data	datum	NOUN
admet-553	557	16	.	.	PUNCT
admet-553	558	1	chemosphere	chemosphere	PROPN
admet-553	558	2	201	201	NUM
admet-553	558	3	(	(	PUNCT
admet-553	558	4	2018	2018	NUM
admet-553	558	5	)	)	PUNCT
admet-553	558	6	432	432	NUM
admet-553	558	7	-	-	SYM
admet-553	558	8	440	440	NUM
admet-553	558	9	.	.	PUNCT
admet-553	559	1	[	[	X
admet-553	559	2	97	97	NUM
admet-553	559	3	]	]	X
admet-553	559	4	c.	c.	PROPN
admet-553	559	5	stergiopoulos	stergiopoulos	PROPN
admet-553	559	6	,	,	PUNCT
admet-553	559	7	d.	d.	PROPN
admet-553	559	8	makarouni	makarouni	PROPN
admet-553	559	9	,	,	PUNCT
admet-553	559	10	m.	m.	NOUN
admet-553	559	11	ochsenkuhnpetropoulou	ochsenkuhnpetropoulou	PROPN
admet-553	559	12	,	,	PUNCT
admet-553	559	13	a.	a.	NOUN
admet-553	559	14	tsantilikakoulidou	tsantilikakoulidou	NOUN
admet-553	559	15	,	,	PUNCT
admet-553	559	16	f.	f.	PROPN
admet-553	559	17	tsopelas	tsopelas	PROPN
admet-553	559	18	.	.	PUNCT
admet-553	559	19	immobilized	immobilize	VERB
admet-553	559	20	artificial	artificial	ADJ
admet-553	559	21	membrane	membrane	NOUN
admet-553	559	22	chromatography	chromatography	NOUN
admet-553	559	23	as	as	ADP
admet-553	559	24	a	a	DET
admet-553	559	25	tool	tool	NOUN
admet-553	559	26	for	for	ADP
admet-553	559	27	the	the	DET
admet-553	559	28	prediction	prediction	NOUN
admet-553	559	29	of	of	ADP
admet-553	559	30	ecotoxicity	ecotoxicity	NOUN
admet-553	559	31	of	of	ADP
admet-553	559	32	pesticides	pesticide	NOUN
admet-553	559	33	.	.	PUNCT
admet-553	560	1	2018	2018	NUM
admet-553	560	2	.	.	PUNCT
admet-553	561	1	(	(	PUNCT
admet-553	561	2	unpublished	unpublished	ADJ
admet-553	561	3	results	result	NOUN
admet-553	561	4	)	)	PUNCT
admet-553	561	5	.	.	PUNCT
admet-553	562	1	©	©	PROPN
admet-553	562	2	2018	2018	NUM
admet-553	562	3	by	by	ADP
admet-553	562	4	the	the	DET
admet-553	562	5	authors	author	NOUN
admet-553	562	6	;	;	PUNCT
admet-553	563	1	licensee	licensee	PROPN
admet-553	563	2	iapc	iapc	PROPN
admet-553	563	3	,	,	PUNCT
admet-553	563	4	zagreb	zagreb	PROPN
admet-553	563	5	,	,	PUNCT
admet-553	563	6	croatia	croatia	PROPN
admet-553	563	7	.	.	PUNCT
admet-553	564	1	this	this	DET
admet-553	564	2	article	article	NOUN
admet-553	564	3	is	be	AUX
admet-553	564	4	an	an	DET
admet-553	564	5	open	open	ADJ
admet-553	564	6	-	-	PUNCT
admet-553	564	7	access	access	NOUN
admet-553	564	8	article	article	NOUN
admet-553	564	9	distributed	distribute	VERB
admet-553	564	10	under	under	ADP
admet-553	564	11	the	the	DET
admet-553	564	12	terms	term	NOUN
admet-553	564	13	and	and	CCONJ
admet-553	564	14	conditions	condition	NOUN
admet-553	564	15	of	of	ADP
admet-553	564	16	the	the	DET
admet-553	564	17	creative	creative	ADJ
admet-553	564	18	commons	common	NOUN
admet-553	564	19	attribution	attribution	NOUN
admet-553	564	20	license	license	NOUN
admet-553	564	21	(	(	PUNCT
admet-553	564	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-553	564	23	)	)	PUNCT
admet-553	564	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN