id	sid	tid	token	lemma	pos
admet-557	1	1	development	development	NOUN
admet-557	1	2	and	and	CCONJ
admet-557	1	3	validation	validation	NOUN
admet-557	1	4	of	of	ADP
admet-557	1	5	a	a	DET
admet-557	1	6	novel	novel	ADJ
admet-557	1	7	method	method	NOUN
admet-557	1	8	for	for	ADP
admet-557	1	9	simultaneous	simultaneous	ADJ
admet-557	1	10	quantification	quantification	NOUN
admet-557	1	11	of	of	ADP
admet-557	1	12	enzalutamide	enzalutamide	NOUN
admet-557	1	13	,	,	PUNCT
admet-557	1	14	darolutamide	darolutamide	NOUN
admet-557	1	15	and	and	CCONJ
admet-557	1	16	their	their	PRON
admet-557	1	17	active	active	ADJ
admet-557	1	18	metabolites	metabolite	NOUN
admet-557	1	19	in	in	ADP
admet-557	1	20	mice	mouse	NOUN
admet-557	1	21	dried	dry	VERB
admet-557	1	22	blood	blood	NOUN
admet-557	1	23	spots	spot	NOUN
admet-557	1	24	using	use	VERB
admet-557	1	25	lc	lc	PROPN
admet-557	1	26	-	-	PUNCT
admet-557	1	27	ms	ms	PROPN
admet-557	1	28	/	/	SYM
admet-557	1	29	ms	ms	NOUN
admet-557	1	30	:	:	PUNCT
admet-557	1	31	application	application	NOUN
admet-557	1	32	to	to	ADP
admet-557	1	33	pharmacokinetic	pharmacokinetic	ADJ
admet-557	1	34	study	study	NOUN
admet-557	1	35	in	in	ADP
admet-557	1	36	mice	mouse	NOUN
admet-557	1	37	doi	doi	NOUN
admet-557	1	38	:	:	PUNCT
admet-557	1	39	10.5599	10.5599	NUM
admet-557	1	40	/	/	SYM
admet-557	1	41	admet.557	admet.557	PROPN
admet-557	1	42	242	242	NUM
admet-557	1	43	admet	admet	X
admet-557	1	44	&	&	CCONJ
admet-557	1	45	dmpk	dmpk	PROPN
admet-557	1	46	6(3	6(3	PROPN
admet-557	1	47	)	)	PUNCT
admet-557	1	48	(	(	PUNCT
admet-557	1	49	2018	2018	NUM
admet-557	1	50	)	)	PUNCT
admet-557	1	51	242	242	NUM
admet-557	1	52	-	-	SYM
admet-557	1	53	257	257	NUM
admet-557	1	54	;	;	PUNCT
admet-557	1	55	doi	doi	NOUN
admet-557	1	56	:	:	PUNCT
admet-557	1	57	http://dx.doi.org/10.5599/admet.557	http://dx.doi.org/10.5599/admet.557	X
admet-557	1	58	open	open	ADJ
admet-557	1	59	access	access	NOUN
admet-557	1	60	:	:	PUNCT
admet-557	1	61	issn	issn	PROPN
admet-557	1	62	:	:	PUNCT
admet-557	1	63	1848	1848	NUM
admet-557	1	64	-	-	SYM
admet-557	1	65	7718	7718	NUM
admet-557	1	66	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-557	1	67	original	original	ADJ
admet-557	1	68	scientific	scientific	ADJ
admet-557	1	69	paper	paper	NOUN
admet-557	1	70	development	development	NOUN
admet-557	1	71	and	and	CCONJ
admet-557	1	72	validation	validation	NOUN
admet-557	1	73	of	of	ADP
admet-557	1	74	a	a	DET
admet-557	1	75	novel	novel	ADJ
admet-557	1	76	method	method	NOUN
admet-557	1	77	for	for	ADP
admet-557	1	78	simultaneous	simultaneous	ADJ
admet-557	1	79	quantification	quantification	NOUN
admet-557	1	80	of	of	ADP
admet-557	1	81	enzalutamide	enzalutamide	NOUN
admet-557	1	82	,	,	PUNCT
admet-557	1	83	darolutamide	darolutamide	NOUN
admet-557	1	84	and	and	CCONJ
admet-557	1	85	their	their	PRON
admet-557	1	86	active	active	ADJ
admet-557	1	87	metabolites	metabolite	NOUN
admet-557	1	88	in	in	ADP
admet-557	1	89	mice	mouse	NOUN
admet-557	1	90	dried	dry	VERB
admet-557	1	91	blood	blood	NOUN
admet-557	1	92	spots	spot	NOUN
admet-557	1	93	using	use	VERB
admet-557	1	94	lcms	lcms	PROPN
admet-557	1	95	/	/	SYM
admet-557	1	96	ms	ms	PROPN
admet-557	1	97	:	:	PUNCT
admet-557	1	98	application	application	NOUN
admet-557	1	99	to	to	ADP
admet-557	1	100	pharmacokinetic	pharmacokinetic	ADJ
admet-557	1	101	study	study	NOUN
admet-557	1	102	in	in	ADP
admet-557	1	103	mice	mouse	NOUN
admet-557	1	104	neraj	neraj	VERB
admet-557	1	105	kumar	kumar	PROPN
admet-557	1	106	saini	saini	PROPN
admet-557	1	107	,	,	PUNCT
admet-557	1	108	suresh	suresh	PROPN
admet-557	1	109	p.	p.	PROPN
admet-557	1	110	sulochana	sulochana	PROPN
admet-557	1	111	,	,	PUNCT
admet-557	1	112	mohd	mohd	PROPN
admet-557	1	113	zainuddin	zainuddin	PROPN
admet-557	1	114	,	,	PUNCT
admet-557	1	115	ramesh	ramesh	PROPN
admet-557	1	116	mullangi	mullangi	PROPN
admet-557	1	117	*	*	PUNCT
admet-557	1	118	drug	drug	NOUN
admet-557	1	119	metabolism	metabolism	NOUN
admet-557	1	120	and	and	CCONJ
admet-557	1	121	pharmacokinetics	pharmacokinetic	NOUN
admet-557	1	122	,	,	PUNCT
admet-557	1	123	jubilant	jubilant	ADJ
admet-557	1	124	biosys	biosy	NOUN
admet-557	1	125	,	,	PUNCT
admet-557	1	126	industrial	industrial	ADJ
admet-557	1	127	suburb	suburb	NOUN
admet-557	1	128	,	,	PUNCT
admet-557	1	129	yeshwanthpur	yeshwanthpur	PROPN
admet-557	1	130	,	,	PUNCT
admet-557	1	131	bangalore-560	bangalore-560	PROPN
admet-557	1	132	022	022	NUM
admet-557	1	133	,	,	PUNCT
admet-557	1	134	india	india	PROPN
admet-557	1	135	*	*	PUNCT
admet-557	1	136	corresponding	correspond	VERB
admet-557	1	137	author	author	NOUN
admet-557	1	138	:	:	PUNCT
admet-557	1	139	e	e	NOUN
admet-557	1	140	-	-	NOUN
admet-557	1	141	mail	mail	NOUN
admet-557	1	142	:	:	PUNCT
admet-557	1	143	mullangi.ramesh@jubilantinnovation.com	mullangi.ramesh@jubilantinnovation.com	X
admet-557	1	144	;	;	PUNCT
admet-557	1	145	tel	tel	PROPN
admet-557	1	146	.	.	PUNCT
admet-557	1	147	:	:	PUNCT
admet-557	2	1	+91	+91	NOUN
admet-557	2	2	-	-	PUNCT
admet-557	2	3	80	80	NUM
admet-557	2	4	-	-	PUNCT
admet-557	2	5	66628339	66628339	NUM
admet-557	2	6	received	receive	VERB
admet-557	2	7	:	:	PUNCT
admet-557	2	8	june	june	PROPN
admet-557	2	9	08	08	NUM
admet-557	2	10	,	,	PUNCT
admet-557	2	11	2018	2018	NUM
admet-557	2	12	;	;	PUNCT
admet-557	2	13	revised	revise	VERB
admet-557	2	14	:	:	PUNCT
admet-557	2	15	july	july	PROPN
admet-557	2	16	05	05	NUM
admet-557	2	17	,	,	PUNCT
admet-557	2	18	2018	2018	NUM
admet-557	2	19	;	;	PUNCT
admet-557	2	20	available	available	ADJ
admet-557	2	21	online	online	NOUN
admet-557	2	22	:	:	PUNCT
admet-557	2	23	july	july	PROPN
admet-557	2	24	15	15	NUM
admet-557	2	25	,	,	PUNCT
admet-557	2	26	2018	2018	NUM
admet-557	2	27	abstract	abstract	NOUN
admet-557	2	28	a	a	DET
admet-557	2	29	simple	simple	ADJ
admet-557	2	30	,	,	PUNCT
admet-557	2	31	sensitive	sensitive	ADJ
admet-557	2	32	and	and	CCONJ
admet-557	2	33	rapid	rapid	ADJ
admet-557	2	34	assay	assay	NOUN
admet-557	2	35	method	method	NOUN
admet-557	2	36	has	have	AUX
admet-557	2	37	been	be	AUX
admet-557	2	38	developed	develop	VERB
admet-557	2	39	and	and	CCONJ
admet-557	2	40	validated	validate	VERB
admet-557	2	41	for	for	ADP
admet-557	2	42	the	the	DET
admet-557	2	43	estimation	estimation	NOUN
admet-557	2	44	of	of	ADP
admet-557	2	45	enzalutamide	enzalutamide	NOUN
admet-557	2	46	,	,	PUNCT
admet-557	2	47	n	n	CCONJ
admet-557	2	48	-	-	PUNCT
admet-557	2	49	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	2	50	(	(	PUNCT
admet-557	2	51	active	active	ADJ
admet-557	2	52	metabolite	metabolite	NOUN
admet-557	2	53	of	of	ADP
admet-557	2	54	enzalutamide	enzalutamide	NOUN
admet-557	2	55	)	)	PUNCT
admet-557	2	56	,	,	PUNCT
admet-557	2	57	darolutamide	darolutamide	NOUN
admet-557	2	58	and	and	CCONJ
admet-557	2	59	orm15341	orm15341	NOUN
admet-557	2	60	(	(	PUNCT
admet-557	2	61	active	active	ADJ
admet-557	2	62	metabolite	metabolite	NOUN
admet-557	2	63	of	of	ADP
admet-557	2	64	darolutamide	darolutamide	NOUN
admet-557	2	65	)	)	PUNCT
admet-557	2	66	on	on	ADP
admet-557	2	67	mice	mouse	NOUN
admet-557	2	68	dried	dry	VERB
admet-557	2	69	blood	blood	NOUN
admet-557	2	70	spots	spot	NOUN
admet-557	2	71	(	(	PUNCT
admet-557	2	72	dbs	dbs	PROPN
admet-557	2	73	)	)	PUNCT
admet-557	2	74	using	use	VERB
admet-557	2	75	liquid	liquid	ADJ
admet-557	2	76	chromatography	chromatography	NOUN
admet-557	2	77	coupled	couple	VERB
admet-557	2	78	to	to	PART
admet-557	2	79	tandem	tandem	VERB
admet-557	2	80	mass	mass	ADJ
admet-557	2	81	spectrometry	spectrometry	NOUN
admet-557	2	82	with	with	ADP
admet-557	2	83	electro	electro	NOUN
admet-557	2	84	spray	spray	VERB
admet-557	2	85	ionization	ionization	NOUN
admet-557	2	86	in	in	ADP
admet-557	2	87	the	the	DET
admet-557	2	88	positive	positive	ADJ
admet-557	2	89	-	-	PUNCT
admet-557	2	90	ion	ion	NOUN
admet-557	2	91	mode	mode	NOUN
admet-557	2	92	.	.	PUNCT
admet-557	3	1	the	the	DET
admet-557	3	2	method	method	NOUN
admet-557	3	3	utilizes	utilize	VERB
admet-557	3	4	liquid	liquid	ADJ
admet-557	3	5	extraction	extraction	NOUN
admet-557	3	6	of	of	ADP
admet-557	3	7	enzalutamide	enzalutamide	NOUN
admet-557	3	8	,	,	PUNCT
admet-557	3	9	n	n	CCONJ
admet-557	3	10	-	-	PUNCT
admet-557	3	11	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	3	12	,	,	PUNCT
admet-557	3	13	darolutamide	darolutamide	NOUN
admet-557	3	14	and	and	CCONJ
admet-557	3	15	orm-15341	orm-15341	NOUN
admet-557	3	16	from	from	ADP
admet-557	3	17	3	3	NUM
admet-557	3	18	mm	mm	NOUN
admet-557	3	19	punched	punch	VERB
admet-557	3	20	disks	disk	NOUN
admet-557	3	21	from	from	ADP
admet-557	3	22	dbs	dbs	PROPN
admet-557	3	23	cards	card	NOUN
admet-557	3	24	(	(	PUNCT
admet-557	3	25	spiked	spiked	ADJ
admet-557	3	26	or	or	CCONJ
admet-557	3	27	study	study	NOUN
admet-557	3	28	samples	sample	NOUN
admet-557	3	29	)	)	PUNCT
admet-557	3	30	.	.	PUNCT
admet-557	4	1	the	the	DET
admet-557	4	2	extracted	extract	VERB
admet-557	4	3	sample	sample	NOUN
admet-557	4	4	was	be	AUX
admet-557	4	5	chromatographed	chromatographe	VERB
admet-557	4	6	using	use	VERB
admet-557	4	7	an	an	DET
admet-557	4	8	isocratic	isocratic	ADJ
admet-557	4	9	mobile	mobile	ADJ
admet-557	4	10	phase	phase	NOUN
admet-557	4	11	(	(	PUNCT
admet-557	4	12	0.2	0.2	NUM
admet-557	4	13	%	%	NOUN
admet-557	4	14	formic	formic	PROPN
admet-557	4	15	acid	acid	NOUN
admet-557	4	16	:	:	PUNCT
admet-557	4	17	acetonitrile	acetonitrile	NOUN
admet-557	4	18	;	;	PUNCT
admet-557	4	19	30:70	30:70	NUM
admet-557	4	20	,	,	PUNCT
admet-557	4	21	v	v	NOUN
admet-557	4	22	/	/	SYM
admet-557	4	23	v	v	NOUN
admet-557	4	24	)	)	PUNCT
admet-557	4	25	on	on	ADP
admet-557	4	26	an	an	DET
admet-557	4	27	atlantis	atlantis	PROPN
admet-557	4	28	dc18	dc18	PROPN
admet-557	4	29	column	column	NOUN
admet-557	4	30	.	.	PUNCT
admet-557	5	1	the	the	DET
admet-557	5	2	total	total	ADJ
admet-557	5	3	run	run	NOUN
admet-557	5	4	time	time	NOUN
admet-557	5	5	was	be	AUX
admet-557	5	6	2.5	2.5	NUM
admet-557	5	7	min	min	NOUN
admet-557	5	8	.	.	PUNCT
admet-557	6	1	the	the	DET
admet-557	6	2	ms	ms	PROPN
admet-557	6	3	/	/	SYM
admet-557	6	4	ms	ms	PROPN
admet-557	6	5	ion	ion	NOUN
admet-557	6	6	transitions	transition	NOUN
admet-557	6	7	monitored	monitor	VERB
admet-557	6	8	were	be	AUX
admet-557	6	9	m	m	PROPN
admet-557	6	10	/	/	SYM
admet-557	6	11	z	z	PROPN
admet-557	6	12	465	465	NUM
admet-557	6	13	→	→	SYM
admet-557	6	14	m	m	NOUN
admet-557	6	15	/	/	SYM
admet-557	6	16	z	z	PROPN
admet-557	6	17	209	209	NUM
admet-557	6	18	,	,	PUNCT
admet-557	6	19	m	m	NOUN
admet-557	6	20	/	/	SYM
admet-557	6	21	z	z	NOUN
admet-557	6	22	451	451	NUM
admet-557	6	23	→	→	SYM
admet-557	6	24	m	m	NOUN
admet-557	6	25	/	/	SYM
admet-557	6	26	z	z	PROPN
admet-557	6	27	195	195	NUM
admet-557	6	28	,	,	PUNCT
admet-557	6	29	m	m	NOUN
admet-557	6	30	/	/	SYM
admet-557	6	31	z	z	PROPN
admet-557	6	32	399	399	NUM
admet-557	6	33	→	→	SYM
admet-557	6	34	m	m	NOUN
admet-557	6	35	/	/	SYM
admet-557	6	36	z	z	PROPN
admet-557	6	37	178	178	NUM
admet-557	6	38	,	,	PUNCT
admet-557	6	39	m	m	NOUN
admet-557	6	40	/	/	SYM
admet-557	6	41	z	z	PROPN
admet-557	6	42	397	397	NUM
admet-557	6	43	→	→	SYM
admet-557	6	44	m	m	NOUN
admet-557	6	45	/	/	SYM
admet-557	6	46	z	z	PROPN
admet-557	6	47	194	194	NUM
admet-557	6	48	and	and	CCONJ
admet-557	6	49	m	m	PROPN
admet-557	6	50	/	/	SYM
admet-557	6	51	z	z	PROPN
admet-557	6	52	481	481	NUM
admet-557	6	53	→	→	SYM
admet-557	6	54	m	m	NOUN
admet-557	6	55	/	/	SYM
admet-557	6	56	z	z	NOUN
admet-557	6	57	453	453	NUM
admet-557	6	58	for	for	ADP
admet-557	6	59	enzalutamide	enzalutamide	NOUN
admet-557	6	60	,	,	PUNCT
admet-557	6	61	n	n	CCONJ
admet-557	6	62	-	-	PUNCT
admet-557	6	63	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	6	64	,	,	PUNCT
admet-557	6	65	darolutamide	darolutamide	NOUN
admet-557	6	66	,	,	PUNCT
admet-557	6	67	orm-15341	orm-15341	NOUN
admet-557	6	68	and	and	CCONJ
admet-557	6	69	the	the	DET
admet-557	6	70	is	be	AUX
admet-557	6	71	(	(	PUNCT
admet-557	6	72	apalutamide	apalutamide	NOUN
admet-557	6	73	-	-	PUNCT
admet-557	6	74	d3	d3	PROPN
admet-557	6	75	)	)	PUNCT
admet-557	6	76	,	,	PUNCT
admet-557	6	77	respectively	respectively	ADV
admet-557	6	78	.	.	PUNCT
admet-557	7	1	method	method	PROPN
admet-557	7	2	validation	validation	NOUN
admet-557	7	3	was	be	AUX
admet-557	7	4	performed	perform	VERB
admet-557	7	5	as	as	ADP
admet-557	7	6	per	per	ADP
admet-557	7	7	regulatory	regulatory	ADJ
admet-557	7	8	guideline	guideline	NOUN
admet-557	7	9	.	.	PUNCT
admet-557	8	1	the	the	DET
admet-557	8	2	assay	assay	NOUN
admet-557	8	3	had	have	VERB
admet-557	8	4	a	a	DET
admet-557	8	5	good	good	ADJ
admet-557	8	6	linearity	linearity	NOUN
admet-557	8	7	over	over	ADP
admet-557	8	8	the	the	DET
admet-557	8	9	range	range	NOUN
admet-557	8	10	of	of	ADP
admet-557	8	11	0.93	0.93	NUM
admet-557	8	12	-	-	PUNCT
admet-557	8	13	2000	2000	NUM
admet-557	8	14	ng	ng	PROPN
admet-557	8	15	/	/	SYM
admet-557	8	16	ml	ml	PROPN
admet-557	8	17	.	.	PUNCT
admet-557	9	1	the	the	DET
admet-557	9	2	intraand	intraand	NOUN
admet-557	9	3	inter	inter	ADJ
admet-557	9	4	-	-	NOUN
admet-557	9	5	batch	batch	NOUN
admet-557	9	6	accuracy	accuracy	NOUN
admet-557	9	7	and	and	CCONJ
admet-557	9	8	precision	precision	NOUN
admet-557	9	9	(	(	PUNCT
admet-557	9	10	%	%	INTJ
admet-557	9	11	re	re	X
admet-557	9	12	&	&	CCONJ
admet-557	9	13	rsd	rsd	PROPN
admet-557	9	14	)	)	PUNCT
admet-557	9	15	across	across	ADP
admet-557	9	16	quality	quality	NOUN
admet-557	9	17	controls	control	NOUN
admet-557	9	18	met	meet	VERB
admet-557	9	19	the	the	DET
admet-557	9	20	acceptance	acceptance	NOUN
admet-557	9	21	criteria	criterion	NOUN
admet-557	9	22	for	for	ADP
admet-557	9	23	all	all	DET
admet-557	9	24	the	the	DET
admet-557	9	25	analytes	analyte	NOUN
admet-557	9	26	.	.	PUNCT
admet-557	10	1	stability	stability	NOUN
admet-557	10	2	studies	study	NOUN
admet-557	10	3	showed	show	VERB
admet-557	10	4	that	that	SCONJ
admet-557	10	5	all	all	DET
admet-557	10	6	the	the	DET
admet-557	10	7	analytes	analyte	NOUN
admet-557	10	8	were	be	AUX
admet-557	10	9	stable	stable	ADJ
admet-557	10	10	on	on	ADP
admet-557	10	11	dbs	dbs	PROPN
admet-557	10	12	cards	card	NOUN
admet-557	10	13	for	for	ADP
admet-557	10	14	one	one	NUM
admet-557	10	15	month	month	NOUN
admet-557	10	16	.	.	PUNCT
admet-557	11	1	this	this	DET
admet-557	11	2	novel	novel	ADJ
admet-557	11	3	method	method	NOUN
admet-557	11	4	has	have	AUX
admet-557	11	5	been	be	AUX
admet-557	11	6	applied	apply	VERB
admet-557	11	7	to	to	PART
admet-557	11	8	analyze	analyze	VERB
admet-557	11	9	the	the	DET
admet-557	11	10	dbs	dbs	PROPN
admet-557	11	11	samples	sample	NOUN
admet-557	11	12	of	of	ADP
admet-557	11	13	enzalutamide	enzalutamide	ADJ
admet-557	11	14	,	,	PUNCT
admet-557	11	15	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	11	16	,	,	PUNCT
admet-557	11	17	darolutamide	darolutamide	NOUN
admet-557	11	18	and	and	CCONJ
admet-557	11	19	orm-15341	orm-15341	NOUN
admet-557	11	20	obtained	obtain	VERB
admet-557	11	21	from	from	ADP
admet-557	11	22	a	a	DET
admet-557	11	23	pharmacokinetic	pharmacokinetic	ADJ
admet-557	11	24	study	study	NOUN
admet-557	11	25	in	in	ADP
admet-557	11	26	mice	mouse	NOUN
admet-557	11	27	.	.	PUNCT
admet-557	12	1	keywords	keyword	NOUN
admet-557	12	2	enzalutamide	enzalutamide	ADV
admet-557	12	3	;	;	PUNCT
admet-557	12	4	n	n	CCONJ
admet-557	12	5	-	-	PUNCT
admet-557	12	6	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	12	7	;	;	PUNCT
admet-557	12	8	darolutamide	darolutamide	ADJ
admet-557	12	9	;	;	PUNCT
admet-557	12	10	orm-15341	orm-15341	NOUN
admet-557	12	11	;	;	PUNCT
admet-557	12	12	dried	dry	VERB
admet-557	12	13	blood	blood	NOUN
admet-557	12	14	spot	spot	NOUN
admet-557	12	15	;	;	PUNCT
admet-557	12	16	lc	lc	PROPN
admet-557	12	17	-	-	PUNCT
admet-557	12	18	ms	ms	PROPN
admet-557	12	19	/	/	SYM
admet-557	12	20	ms	ms	PROPN
admet-557	12	21	;	;	PUNCT
admet-557	12	22	method	method	NOUN
admet-557	12	23	validation	validation	NOUN
admet-557	12	24	;	;	PUNCT
admet-557	12	25	mice	mouse	NOUN
admet-557	12	26	;	;	PUNCT
admet-557	12	27	pharmacokinetics	pharmacokinetic	NOUN
admet-557	12	28	introduction	introduction	NOUN
admet-557	12	29	despite	despite	SCONJ
admet-557	12	30	therapeutic	therapeutic	ADJ
admet-557	12	31	advances	advance	NOUN
admet-557	12	32	,	,	PUNCT
admet-557	12	33	prostate	prostate	NOUN
admet-557	12	34	adenocarcinoma	adenocarcinoma	NOUN
admet-557	12	35	is	be	AUX
admet-557	12	36	the	the	DET
admet-557	12	37	highly	highly	ADV
admet-557	12	38	prevalent	prevalent	ADJ
admet-557	12	39	cancer	cancer	NOUN
admet-557	12	40	in	in	ADP
admet-557	12	41	men	man	NOUN
admet-557	12	42	and	and	CCONJ
admet-557	12	43	responsible	responsible	ADJ
admet-557	12	44	for	for	ADP
admet-557	12	45	20	20	NUM
admet-557	12	46	%	%	NOUN
admet-557	12	47	of	of	ADP
admet-557	12	48	cancer	cancer	NOUN
admet-557	12	49	related	relate	VERB
admet-557	12	50	deaths	death	NOUN
admet-557	12	51	in	in	ADP
admet-557	12	52	the	the	DET
admet-557	12	53	western	western	ADJ
admet-557	12	54	world	world	NOUN
admet-557	13	1	[	[	X
admet-557	13	2	1	1	NUM
admet-557	13	3	]	]	PUNCT
admet-557	13	4	.	.	PUNCT
admet-557	14	1	initial	initial	ADJ
admet-557	14	2	approach	approach	NOUN
admet-557	14	3	to	to	PART
admet-557	14	4	cure	cure	VERB
admet-557	14	5	the	the	DET
admet-557	14	6	localized	localize	VERB
admet-557	14	7	prostate	prostate	NOUN
admet-557	14	8	cancer	cancer	NOUN
admet-557	14	9	is	be	AUX
admet-557	14	10	through	through	ADP
admet-557	14	11	radiation	radiation	NOUN
admet-557	14	12	therapy	therapy	NOUN
admet-557	14	13	or	or	CCONJ
admet-557	14	14	surgical	surgical	ADJ
admet-557	14	15	castration	castration	NOUN
admet-557	14	16	or	or	CCONJ
admet-557	14	17	treatment	treatment	NOUN
admet-557	14	18	with	with	ADP
admet-557	14	19	firstgeneration	firstgeneration	NOUN
admet-557	14	20	anti	anti	ADJ
admet-557	14	21	-	-	ADJ
admet-557	14	22	androgens	androgens	ADJ
admet-557	14	23	(	(	PUNCT
admet-557	14	24	flutamide	flutamide	NOUN
admet-557	14	25	,	,	PUNCT
admet-557	14	26	nilutamide	nilutamide	ADV
admet-557	14	27	,	,	PUNCT
admet-557	14	28	bicalutamide	bicalutamide	VERB
admet-557	14	29	etc	etc	X
admet-557	14	30	.	.	PUNCT
admet-557	14	31	)	)	PUNCT
admet-557	15	1	[	[	X
admet-557	15	2	2	2	NUM
admet-557	15	3	]	]	PUNCT
admet-557	15	4	.	.	PUNCT
admet-557	16	1	however	however	ADV
admet-557	16	2	,	,	PUNCT
admet-557	16	3	despite	despite	SCONJ
admet-557	16	4	an	an	DET
admet-557	16	5	initial	initial	ADJ
admet-557	16	6	response	response	NOUN
admet-557	16	7	,	,	PUNCT
admet-557	16	8	most	most	ADJ
admet-557	16	9	patients	patient	NOUN
admet-557	16	10	develop	develop	VERB
admet-557	16	11	a	a	DET
admet-557	16	12	most	most	ADV
admet-557	16	13	aggressive	aggressive	ADJ
admet-557	16	14	form	form	NOUN
admet-557	16	15	of	of	ADP
admet-557	16	16	disease	disease	NOUN
admet-557	16	17	called	call	VERB
admet-557	16	18	metastatic	metastatic	ADJ
admet-557	16	19	castration	castration	NOUN
admet-557	16	20	-	-	PUNCT
admet-557	16	21	resistant	resistant	ADJ
admet-557	16	22	prostate	prostate	NOUN
admet-557	16	23	cancer	cancer	NOUN
admet-557	16	24	(	(	PUNCT
admet-557	16	25	mcrpc	mcrpc	NOUN
admet-557	16	26	)	)	PUNCT
admet-557	16	27	that	that	PRON
admet-557	16	28	is	be	AUX
admet-557	16	29	associated	associate	VERB
admet-557	16	30	with	with	ADP
admet-557	16	31	tumor	tumor	NOUN
admet-557	16	32	progression	progression	NOUN
admet-557	16	33	and	and	CCONJ
admet-557	16	34	survival	survival	NOUN
admet-557	16	35	less	less	ADJ
admet-557	16	36	than	than	ADP
admet-557	16	37	18	18	NUM
admet-557	16	38	-	-	SYM
admet-557	16	39	24	24	NUM
admet-557	16	40	months	month	NOUN
admet-557	16	41	[	[	X
admet-557	16	42	3	3	NUM
admet-557	16	43	]	]	PUNCT
admet-557	16	44	.	.	PUNCT
admet-557	17	1	consequently	consequently	ADV
admet-557	17	2	,	,	PUNCT
admet-557	17	3	in	in	ADP
admet-557	17	4	recent	recent	ADJ
admet-557	17	5	years	year	NOUN
admet-557	17	6	,	,	PUNCT
admet-557	17	7	new	new	ADJ
admet-557	17	8	therapy	therapy	NOUN
admet-557	17	9	options	option	NOUN
admet-557	17	10	for	for	ADP
admet-557	17	11	mcrpc	mcrpc	NOUN
admet-557	17	12	with	with	ADP
admet-557	17	13	different	different	ADJ
admet-557	17	14	mechanisms	mechanism	NOUN
admet-557	17	15	of	of	ADP
admet-557	17	16	action	action	NOUN
admet-557	17	17	have	have	VERB
admet-557	17	18	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-557	17	19	mailto:mullangi.ramesh@jubilantinnovation.com	mailto:mullangi.ramesh@jubilantinnovation.com	PROPN
admet-557	17	20	admet	admet	PROPN
admet-557	17	21	&	&	CCONJ
admet-557	17	22	dmpk	dmpk	PROPN
admet-557	17	23	6(3	6(3	PROPN
admet-557	17	24	)	)	PUNCT
admet-557	17	25	(	(	PUNCT
admet-557	17	26	2018	2018	NUM
admet-557	17	27	)	)	PUNCT
admet-557	17	28	242	242	NUM
admet-557	17	29	-	-	SYM
admet-557	17	30	257	257	NUM
admet-557	17	31	lc	lc	PROPN
admet-557	17	32	-	-	PUNCT
admet-557	17	33	ms	ms	PROPN
admet-557	17	34	/	/	SYM
admet-557	17	35	ms	ms	NOUN
admet-557	17	36	determination	determination	NOUN
admet-557	17	37	of	of	ADP
admet-557	17	38	enzalutamide	enzalutamide	ADV
admet-557	17	39	/	/	SYM
admet-557	17	40	darolutamide	darolutamide	NOUN
admet-557	17	41	with	with	ADP
admet-557	17	42	metabolites	metabolite	NOUN
admet-557	17	43	on	on	ADP
admet-557	17	44	dbs	dbs	PROPN
admet-557	17	45	doi	doi	PROPN
admet-557	17	46	:	:	PUNCT
admet-557	17	47	10.5599	10.5599	NUM
admet-557	17	48	/	/	SYM
admet-557	17	49	admet.557	admet.557	PROPN
admet-557	17	50	243	243	NUM
admet-557	17	51	become	become	VERB
admet-557	17	52	available	available	ADJ
admet-557	17	53	like	like	ADP
admet-557	17	54	targeting	target	VERB
admet-557	17	55	androgen	androgen	NOUN
admet-557	17	56	receptor	receptor	NOUN
admet-557	17	57	signalling	signal	VERB
admet-557	17	58	such	such	ADJ
admet-557	17	59	as	as	ADP
admet-557	17	60	cyp17a1	cyp17a1	NOUN
admet-557	17	61	inhibitor	inhibitor	NOUN
admet-557	17	62	(	(	PUNCT
admet-557	17	63	abiraterone	abiraterone	NOUN
admet-557	17	64	acetate	acetate	NOUN
admet-557	17	65	)	)	PUNCT
admet-557	18	1	[	[	X
admet-557	18	2	4	4	X
admet-557	18	3	]	]	PUNCT
admet-557	18	4	and	and	CCONJ
admet-557	18	5	a	a	DET
admet-557	18	6	second	second	ADJ
admet-557	18	7	-	-	PUNCT
admet-557	18	8	generation	generation	NOUN
admet-557	18	9	androgen	androgen	NOUN
admet-557	18	10	receptor	receptor	NOUN
admet-557	18	11	antagonist	antagonist	NOUN
admet-557	18	12	(	(	PUNCT
admet-557	18	13	enzalutamide	enzalutamide	ADJ
admet-557	18	14	,	,	PUNCT
admet-557	18	15	apalutamide	apalutamide	ADJ
admet-557	18	16	and	and	CCONJ
admet-557	18	17	darolutamide	darolutamide	ADJ
admet-557	18	18	)	)	PUNCT
admet-557	19	1	[	[	X
admet-557	19	2	5	5	NUM
admet-557	19	3	-	-	SYM
admet-557	19	4	7	7	NUM
admet-557	19	5	]	]	PUNCT
admet-557	19	6	.	.	PUNCT
admet-557	20	1	treatment	treatment	NOUN
admet-557	20	2	with	with	ADP
admet-557	20	3	these	these	DET
admet-557	20	4	drugs	drug	NOUN
admet-557	20	5	showed	show	VERB
admet-557	20	6	improved	improve	VERB
admet-557	20	7	overall	overall	ADJ
admet-557	20	8	survival	survival	NOUN
admet-557	20	9	and	and	CCONJ
admet-557	20	10	quality	quality	NOUN
admet-557	20	11	of	of	ADP
admet-557	20	12	life	life	NOUN
admet-557	20	13	in	in	ADP
admet-557	20	14	mcrpc	mcrpc	PROPN
admet-557	20	15	patients	patient	NOUN
admet-557	20	16	.	.	PUNCT
admet-557	21	1	enzalutamide	enzalutamide	INTJ
admet-557	21	2	(	(	PUNCT
admet-557	21	3	xtandi	xtandi	PROPN
admet-557	21	4			PROPN
admet-557	21	5	;	;	PUNCT
admet-557	21	6	fig	fig	NOUN
admet-557	21	7	.	.	NOUN
admet-557	21	8	1	1	NUM
admet-557	21	9	)	)	PUNCT
admet-557	21	10	was	be	AUX
admet-557	21	11	recently	recently	ADV
admet-557	21	12	approved	approve	VERB
admet-557	21	13	for	for	ADP
admet-557	21	14	the	the	DET
admet-557	21	15	treatment	treatment	NOUN
admet-557	21	16	of	of	ADP
admet-557	21	17	mcrpc	mcrpc	NOUN
admet-557	21	18	[	[	X
admet-557	21	19	5,8	5,8	NUM
admet-557	21	20	]	]	X
admet-557	21	21	.	.	PUNCT
admet-557	22	1	enzalutamide	enzalutamide	PROPN
admet-557	22	2	is	be	AUX
admet-557	22	3	metabolized	metabolize	VERB
admet-557	22	4	by	by	ADP
admet-557	22	5	cyp3a4	cyp3a4	NOUN
admet-557	22	6	and	and	CCONJ
admet-557	22	7	2c8	2c8	NUM
admet-557	22	8	to	to	PART
admet-557	22	9	produce	produce	VERB
admet-557	22	10	an	an	DET
admet-557	22	11	active	active	ADJ
admet-557	22	12	circulatory	circulatory	ADJ
admet-557	22	13	metabolite	metabolite	NOUN
admet-557	22	14	,	,	PUNCT
admet-557	22	15	n	n	CCONJ
admet-557	22	16	-	-	PUNCT
admet-557	22	17	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	22	18	(	(	PUNCT
admet-557	22	19	fig	fig	NOUN
admet-557	22	20	.	.	PUNCT
admet-557	23	1	1	1	NUM
admet-557	23	2	)	)	PUNCT
admet-557	23	3	,	,	PUNCT
admet-557	23	4	which	which	PRON
admet-557	23	5	has	have	AUX
admet-557	23	6	similar	similar	ADJ
admet-557	23	7	in	in	ADP
admet-557	23	8	vitro	vitro	X
admet-557	23	9	potency	potency	NOUN
admet-557	23	10	to	to	ADP
admet-557	23	11	enzalutamide	enzalutamide	NOUN
admet-557	23	12	[	[	X
admet-557	23	13	9,10	9,10	NUM
admet-557	23	14	]	]	X
admet-557	23	15	.	.	PUNCT
admet-557	24	1	darolutamide	darolutamide	PROPN
admet-557	24	2	(	(	PUNCT
admet-557	24	3	odm-201	odm-201	ADJ
admet-557	24	4	;	;	PUNCT
admet-557	24	5	fig	fig	NOUN
admet-557	24	6	.	.	NOUN
admet-557	24	7	1	1	NUM
admet-557	24	8	)	)	PUNCT
admet-557	24	9	is	be	AUX
admet-557	24	10	a	a	DET
admet-557	24	11	novel	novel	NOUN
admet-557	24	12	,	,	PUNCT
admet-557	24	13	orally	orally	ADV
admet-557	24	14	active	active	ADJ
admet-557	24	15	,	,	PUNCT
admet-557	24	16	second	second	ADJ
admet-557	24	17	-	-	PUNCT
admet-557	24	18	generation	generation	NOUN
admet-557	24	19	non	non	ADJ
admet-557	24	20	-	-	ADJ
admet-557	24	21	steroidal	steroidal	ADJ
admet-557	24	22	anti	anti	NOUN
admet-557	24	23	-	-	NOUN
admet-557	24	24	androgen	androgen	NOUN
admet-557	24	25	.	.	PUNCT
admet-557	25	1	it	it	PRON
admet-557	25	2	is	be	AUX
admet-557	25	3	an	an	DET
admet-557	25	4	equi	equi	NOUN
admet-557	25	5	-	-	PUNCT
admet-557	25	6	mixture	mixture	NOUN
admet-557	25	7	of	of	ADP
admet-557	25	8	two	two	NUM
admet-557	25	9	pharmacologically	pharmacologically	ADV
admet-557	25	10	active	active	ADJ
admet-557	25	11	diastereomers	diastereomer	NOUN
admet-557	25	12	namely	namely	ADV
admet-557	25	13	orm-16497	orm-16497	NOUN
admet-557	25	14	and	and	CCONJ
admet-557	25	15	orm-16555	orm-16555	NOUN
admet-557	25	16	.	.	PUNCT
admet-557	26	1	darolutamide	darolutamide	PROPN
admet-557	26	2	undergoes	undergo	VERB
admet-557	26	3	extensive	extensive	ADJ
admet-557	26	4	phase	phase	NOUN
admet-557	26	5	-	-	PUNCT
admet-557	26	6	i	i	PRON
admet-557	26	7	metabolism	metabolism	NOUN
admet-557	26	8	and	and	CCONJ
admet-557	26	9	produces	produce	VERB
admet-557	26	10	circulatory	circulatory	ADJ
admet-557	26	11	metabolite	metabolite	NOUN
admet-557	26	12	i.e.	i.e.	X
admet-557	26	13	,	,	PUNCT
admet-557	26	14	orm-15341	orm-15341	NOUN
admet-557	26	15	(	(	PUNCT
admet-557	26	16	fig	fig	NOUN
admet-557	26	17	.	.	PUNCT
admet-557	27	1	1	1	NUM
admet-557	27	2	)	)	PUNCT
admet-557	27	3	.	.	PUNCT
admet-557	28	1	orm-16497	orm-16497	PROPN
admet-557	28	2	,	,	PUNCT
admet-557	28	3	orm-16555	orm-16555	NOUN
admet-557	28	4	and	and	CCONJ
admet-557	28	5	orm-15341	orm-15341	NOUN
admet-557	28	6	are	be	AUX
admet-557	28	7	fully	fully	ADV
admet-557	28	8	antagonist	antagonist	ADJ
admet-557	28	9	against	against	ADP
admet-557	28	10	bicalutamide	bicalutamide	VERB
admet-557	28	11	,	,	PUNCT
admet-557	28	12	hydroxyflutamide	hydroxyflutamide	NOUN
admet-557	28	13	,	,	PUNCT
admet-557	28	14	enzalutamide	enzalutamide	ADV
admet-557	28	15	and	and	CCONJ
admet-557	28	16	arn-509	arn-509	ADJ
admet-557	28	17	mutants	mutant	NOUN
admet-557	29	1	[	[	X
admet-557	29	2	11,12	11,12	NUM
admet-557	29	3	]	]	PUNCT
admet-557	29	4	.	.	PUNCT
admet-557	30	1	unlike	unlike	ADP
admet-557	30	2	enzalutamide	enzalutamide	ADV
admet-557	30	3	and	and	CCONJ
admet-557	30	4	apalutamide	apalutamide	ADJ
admet-557	30	5	,	,	PUNCT
admet-557	30	6	penetration	penetration	NOUN
admet-557	30	7	of	of	ADP
admet-557	30	8	darolutamide	darolutamide	NOUN
admet-557	30	9	and	and	CCONJ
admet-557	30	10	orm-15341	orm-15341	NOUN
admet-557	30	11	into	into	ADP
admet-557	30	12	brain	brain	NOUN
admet-557	30	13	is	be	AUX
admet-557	30	14	negligible	negligible	ADJ
admet-557	30	15	(	(	PUNCT
admet-557	30	16	in	in	ADP
admet-557	30	17	preclinical	preclinical	ADJ
admet-557	30	18	species	specie	NOUN
admet-557	30	19	)	)	PUNCT
admet-557	31	1	suggests	suggest	VERB
admet-557	31	2	that	that	SCONJ
admet-557	31	3	low	low	ADJ
admet-557	31	4	risk	risk	NOUN
admet-557	31	5	of	of	ADP
admet-557	31	6	causing	cause	VERB
admet-557	31	7	seizures	seizure	NOUN
admet-557	31	8	in	in	ADP
admet-557	31	9	patients	patient	NOUN
admet-557	31	10	[	[	X
admet-557	31	11	7	7	NUM
admet-557	31	12	]	]	PUNCT
admet-557	31	13	.	.	PUNCT
admet-557	32	1	in	in	ADP
admet-557	32	2	clinic	clinic	NOUN
admet-557	32	3	,	,	PUNCT
admet-557	32	4	darolutamide	darolutamide	PROPN
admet-557	32	5	was	be	AUX
admet-557	32	6	tolerated	tolerate	VERB
admet-557	32	7	up	up	ADP
admet-557	32	8	to	to	ADP
admet-557	32	9	1800	1800	NUM
admet-557	32	10	mg	mg	NOUN
admet-557	33	1	and	and	CCONJ
admet-557	33	2	no	no	DET
admet-557	33	3	dose	dose	NOUN
admet-557	33	4	-	-	PUNCT
admet-557	33	5	limiting	limit	VERB
admet-557	33	6	toxic	toxic	ADJ
admet-557	33	7	effects	effect	NOUN
admet-557	33	8	were	be	AUX
admet-557	33	9	reported	report	VERB
admet-557	33	10	.	.	PUNCT
admet-557	34	1	it	it	PRON
admet-557	34	2	was	be	AUX
admet-557	34	3	reported	report	VERB
admet-557	34	4	that	that	SCONJ
admet-557	34	5	orm-15341	orm-15341	NOUN
admet-557	34	6	plasma	plasma	NOUN
admet-557	34	7	concentrations	concentration	NOUN
admet-557	34	8	were	be	AUX
admet-557	34	9	higher	high	ADJ
admet-557	34	10	than	than	ADP
admet-557	34	11	sum	sum	NOUN
admet-557	34	12	of	of	ADP
admet-557	34	13	orm-16497	orm-16497	NOUN
admet-557	34	14	and	and	CCONJ
admet-557	34	15	orm-16555	orm-16555	NOUN
admet-557	34	16	plasma	plasma	NOUN
admet-557	34	17	concentrations	concentration	NOUN
admet-557	34	18	[	[	X
admet-557	34	19	13	13	NUM
admet-557	34	20	]	]	PUNCT
admet-557	34	21	.	.	PUNCT
admet-557	35	1	currently	currently	ADV
admet-557	35	2	phase	phase	NOUN
admet-557	35	3	-	-	PUNCT
admet-557	35	4	iii	iii	NOUN
admet-557	35	5	clinical	clinical	ADJ
admet-557	35	6	trials	trial	NOUN
admet-557	35	7	are	be	AUX
admet-557	35	8	being	be	AUX
admet-557	35	9	conducted	conduct	VERB
admet-557	35	10	with	with	ADP
admet-557	35	11	darolutamide	darolutamide	NOUN
admet-557	35	12	in	in	ADP
admet-557	35	13	non	non	ADJ
admet-557	35	14	-	-	ADJ
admet-557	35	15	mcrpc	mcrpc	ADJ
admet-557	35	16	patients	patient	NOUN
admet-557	35	17	globally	globally	ADV
admet-557	35	18	[	[	X
admet-557	35	19	7	7	NUM
admet-557	35	20	]	]	PUNCT
admet-557	35	21	.	.	PUNCT
admet-557	36	1	n	n	CCONJ
admet-557	37	1	n	n	PROPN
admet-557	37	2	cf	cf	NOUN
admet-557	37	3	3	3	NUM
admet-557	37	4	nc	nc	PROPN
admet-557	37	5	o	o	PROPN
admet-557	37	6	s	s	X
admet-557	37	7	f	f	X
admet-557	37	8	o	o	NOUN
admet-557	37	9	r	r	NOUN
admet-557	37	10	n	n	CCONJ
admet-557	37	11	n	n	PROPN
admet-557	37	12	cl	cl	NOUN
admet-557	37	13	nc	nc	PROPN
admet-557	37	14	n	n	PROPN
admet-557	37	15	n	n	PRON
admet-557	37	16	h	h	NOUN
admet-557	38	1	oh	oh	INTJ
admet-557	38	2	n	n	ADV
admet-557	39	1	h	h	NOUN
admet-557	39	2	o	o	NOUN
admet-557	39	3	enzalutamide	enzalutamide	ADV
admet-557	39	4	,	,	PUNCT
admet-557	39	5	r	r	NOUN
admet-557	39	6	=	=	SYM
admet-557	39	7	nhch3	nhch3	ADJ
admet-557	39	8	n	n	CCONJ
admet-557	39	9	-	-	PUNCT
admet-557	39	10	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	39	11	,	,	PUNCT
admet-557	39	12	r	r	NOUN
admet-557	39	13	=	=	SYM
admet-557	39	14	nh2	nh2	NOUN
admet-557	39	15	darolutamide	darolutamide	NOUN
admet-557	39	16	n	n	CCONJ
admet-557	39	17	n	n	ADV
admet-557	39	18	cl	cl	PROPN
admet-557	39	19	nc	nc	PROPN
admet-557	39	20	n	n	PROPN
admet-557	39	21	n	n	PROPN
admet-557	39	22	h	h	NOUN
admet-557	40	1	n	n	ADV
admet-557	40	2	h	h	NOUN
admet-557	41	1	o	o	NOUN
admet-557	41	2	o	o	NOUN
admet-557	41	3	n	n	CCONJ
admet-557	41	4	n	n	CCONJ
admet-557	41	5	n	n	NOUN
admet-557	41	6	cf	cf	NOUN
admet-557	41	7	3	3	NUM
admet-557	42	1	nc	nc	PROPN
admet-557	42	2	o	o	PROPN
admet-557	42	3	s	s	PROPN
admet-557	42	4	f	f	PROPN
admet-557	42	5	n	n	PROPN
admet-557	42	6	h	h	NOUN
admet-557	42	7	cd	cd	PROPN
admet-557	42	8	3	3	NUM
admet-557	42	9	o	o	NOUN
admet-557	42	10	orm-15341	orm-15341	NOUN
admet-557	42	11	apalutamide	apalutamide	NOUN
admet-557	42	12	-	-	PUNCT
admet-557	42	13	d3	d3	PROPN
admet-557	42	14	(	(	PUNCT
admet-557	42	15	is	be	AUX
admet-557	42	16	)	)	PUNCT
admet-557	42	17	figure	figure	NOUN
admet-557	42	18	1	1	NUM
admet-557	42	19	.	.	PUNCT
admet-557	42	20	structural	structural	ADJ
admet-557	42	21	representation	representation	NOUN
admet-557	42	22	of	of	ADP
admet-557	42	23	enzalutamide	enzalutamide	NOUN
admet-557	42	24	,	,	PUNCT
admet-557	42	25	n	n	CCONJ
admet-557	42	26	-	-	PUNCT
admet-557	42	27	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	42	28	,	,	PUNCT
admet-557	42	29	darolutamide	darolutamide	NOUN
admet-557	42	30	,	,	PUNCT
admet-557	42	31	orm-15341	orm-15341	NOUN
admet-557	42	32	and	and	CCONJ
admet-557	42	33	apalutamide	apalutamide	NOUN
admet-557	42	34	-	-	PUNCT
admet-557	42	35	d3	d3	PROPN
admet-557	42	36	(	(	PUNCT
admet-557	42	37	is	be	AUX
admet-557	42	38	)	)	PUNCT
admet-557	42	39	in	in	ADP
admet-557	42	40	contemporary	contemporary	PROPN
admet-557	42	41	literature	literature	PROPN
admet-557	42	42	few	few	ADJ
admet-557	42	43	lc	lc	PROPN
admet-557	42	44	-	-	PUNCT
admet-557	42	45	ms	ms	PROPN
admet-557	42	46	/	/	SYM
admet-557	42	47	ms	ms	ADJ
admet-557	42	48	bioanalytical	bioanalytical	ADJ
admet-557	42	49	methods	method	NOUN
admet-557	42	50	were	be	AUX
admet-557	42	51	reported	report	VERB
admet-557	42	52	for	for	ADP
admet-557	42	53	quantification	quantification	NOUN
admet-557	42	54	of	of	ADP
admet-557	42	55	enzalutamide	enzalutamide	ADV
admet-557	42	56	alone	alone	ADV
admet-557	43	1	[	[	X
admet-557	43	2	14	14	NUM
admet-557	43	3	]	]	PUNCT
admet-557	43	4	or	or	CCONJ
admet-557	43	5	along	along	ADP
admet-557	43	6	with	with	ADP
admet-557	43	7	its	its	PRON
admet-557	43	8	metabolites	metabolite	NOUN
admet-557	43	9	[	[	X
admet-557	43	10	15,16	15,16	NUM
admet-557	43	11	]	]	PUNCT
admet-557	43	12	and	and	CCONJ
admet-557	43	13	other	other	ADJ
admet-557	43	14	anti	anti	ADJ
admet-557	43	15	-	-	ADJ
admet-557	43	16	androgens	androgens	ADJ
admet-557	44	1	[	[	X
admet-557	44	2	17	17	NUM
admet-557	44	3	-	-	SYM
admet-557	44	4	19	19	NUM
admet-557	44	5	]	]	PUNCT
admet-557	44	6	or	or	CCONJ
admet-557	44	7	anticancer	anticancer	NOUN
admet-557	44	8	drugs	drug	NOUN
admet-557	44	9	[	[	X
admet-557	44	10	20	20	NUM
admet-557	44	11	]	]	PUNCT
admet-557	44	12	in	in	ADP
admet-557	44	13	various	various	ADJ
admet-557	44	14	biological	biological	ADJ
admet-557	44	15	matrices	matrix	NOUN
admet-557	44	16	(	(	PUNCT
admet-557	44	17	preclinical	preclinical	ADJ
admet-557	44	18	species	specie	NOUN
admet-557	44	19	plasma	plasma	NOUN
admet-557	44	20	/	/	SYM
admet-557	44	21	tissues	tissue	NOUN
admet-557	44	22	and	and	CCONJ
admet-557	44	23	human	human	ADJ
admet-557	44	24	plasma	plasma	NOUN
admet-557	44	25	)	)	PUNCT
admet-557	44	26	.	.	PUNCT
admet-557	45	1	similarly	similarly	ADV
admet-557	45	2	darolutamide	darolutamide	ADV
admet-557	45	3	and	and	CCONJ
admet-557	45	4	orm-15341	orm-15341	VERB
admet-557	45	5	quantification	quantification	NOUN
admet-557	45	6	in	in	ADP
admet-557	45	7	mice	mice	NOUN
admet-557	45	8	plasma	plasma	NOUN
admet-557	45	9	was	be	AUX
admet-557	45	10	reported	report	VERB
admet-557	45	11	post	post	ADJ
admet-557	45	12	-	-	NOUN
admet-557	45	13	administration	administration	NOUN
admet-557	45	14	of	of	ADP
admet-557	45	15	darolutamide	darolutamide	NOUN
admet-557	46	1	[	[	X
admet-557	46	2	21	21	NUM
admet-557	46	3	]	]	PUNCT
admet-557	46	4	and	and	CCONJ
admet-557	46	5	along	along	ADP
admet-557	46	6	with	with	ADP
admet-557	46	7	other	other	ADJ
admet-557	46	8	second	second	ADJ
admet-557	46	9	-	-	PUNCT
admet-557	46	10	generation	generation	NOUN
admet-557	46	11	non	non	ADJ
admet-557	46	12	-	-	ADJ
admet-557	46	13	steroidal	steroidal	ADJ
admet-557	46	14	anti	anti	ADJ
admet-557	46	15	-	-	ADJ
admet-557	46	16	androgens	androgens	ADJ
admet-557	46	17	(	(	PUNCT
admet-557	46	18	enzalutamide	enzalutamide	ADV
admet-557	46	19	,	,	PUNCT
admet-557	46	20	apalutamide	apalutamide	ADV
admet-557	46	21	)	)	PUNCT
admet-557	47	1	[	[	X
admet-557	47	2	20	20	NUM
admet-557	47	3	]	]	PUNCT
admet-557	47	4	using	use	VERB
admet-557	47	5	conventional	conventional	ADJ
admet-557	47	6	achiral	achiral	ADJ
admet-557	47	7	columns	column	NOUN
admet-557	47	8	on	on	ADP
admet-557	47	9	lc	lc	PROPN
admet-557	47	10	-	-	PUNCT
admet-557	47	11	ms	ms	PROPN
admet-557	47	12	/	/	SYM
admet-557	47	13	ms	ms	PROPN
admet-557	47	14	.	.	PROPN
admet-557	48	1	apart	apart	ADV
admet-557	48	2	from	from	ADP
admet-557	48	3	these	these	DET
admet-557	48	4	achiral	achiral	ADJ
admet-557	48	5	methods	method	NOUN
admet-557	48	6	,	,	PUNCT
admet-557	48	7	two	two	NUM
admet-557	48	8	chiral	chiral	ADJ
admet-557	48	9	lc	lc	PROPN
admet-557	48	10	-	-	PUNCT
admet-557	48	11	ms	ms	PROPN
admet-557	48	12	/	/	SYM
admet-557	48	13	ms	ms	NOUN
admet-557	48	14	methods	method	NOUN
admet-557	48	15	for	for	ADP
admet-557	48	16	quantification	quantification	NOUN
admet-557	48	17	darolutamide	darolutamide	ADJ
admet-557	48	18	diastereomers	diastereomer	NOUN
admet-557	48	19	alone	alone	ADV
admet-557	49	1	[	[	X
admet-557	49	2	22	22	NUM
admet-557	49	3	]	]	PUNCT
admet-557	49	4	or	or	CCONJ
admet-557	49	5	along	along	ADP
admet-557	49	6	with	with	ADP
admet-557	49	7	its	its	PRON
admet-557	49	8	metabolite	metabolite	NOUN
admet-557	49	9	[	[	X
admet-557	49	10	23	23	NUM
admet-557	49	11	]	]	PUNCT
admet-557	49	12	were	be	AUX
admet-557	49	13	reported	report	VERB
admet-557	49	14	in	in	ADP
admet-557	49	15	recent	recent	ADJ
admet-557	49	16	times	time	NOUN
admet-557	49	17	.	.	PUNCT
admet-557	50	1	traditional	traditional	ADJ
admet-557	50	2	bioanalysis	bioanalysis	NOUN
admet-557	50	3	of	of	ADP
admet-557	50	4	samples	sample	NOUN
admet-557	50	5	from	from	ADP
admet-557	50	6	preclinical	preclinical	ADJ
admet-557	50	7	species	specie	NOUN
admet-557	50	8	and	and	CCONJ
admet-557	50	9	clinical	clinical	ADJ
admet-557	50	10	trials	trial	NOUN
admet-557	50	11	relies	rely	VERB
admet-557	50	12	on	on	ADP
admet-557	50	13	collection	collection	NOUN
admet-557	50	14	of	of	ADP
admet-557	50	15	blood	blood	NOUN
admet-557	50	16	or	or	CCONJ
admet-557	50	17	its	its	PRON
admet-557	50	18	products	product	NOUN
admet-557	50	19	(	(	PUNCT
admet-557	50	20	serum	serum	NOUN
admet-557	50	21	and	and	CCONJ
admet-557	50	22	plasma	plasma	NOUN
admet-557	50	23	)	)	PUNCT
admet-557	50	24	.	.	PUNCT
admet-557	51	1	collection	collection	NOUN
admet-557	51	2	of	of	ADP
admet-557	51	3	blood	blood	NOUN
admet-557	51	4	in	in	ADP
admet-557	51	5	a	a	DET
admet-557	51	6	preclinical	preclinical	NOUN
admet-557	51	7	set	set	VERB
admet-557	51	8	up	up	ADP
admet-557	51	9	especially	especially	ADV
admet-557	51	10	with	with	ADP
admet-557	51	11	rodents	rodent	NOUN
admet-557	51	12	,	,	PUNCT
admet-557	51	13	pediatric	pediatric	ADJ
admet-557	51	14	cases	case	NOUN
admet-557	51	15	and	and	CCONJ
admet-557	51	16	new	new	ADJ
admet-557	51	17	-	-	PUNCT
admet-557	51	18	borns	born	NOUN
admet-557	51	19	is	be	AUX
admet-557	51	20	a	a	DET
admet-557	51	21	challenge	challenge	NOUN
admet-557	51	22	and	and	CCONJ
admet-557	51	23	not	not	PART
admet-557	51	24	possible	possible	ADJ
admet-557	51	25	to	to	PART
admet-557	51	26	draw	draw	VERB
admet-557	51	27	blood	blood	NOUN
admet-557	51	28	samples	sample	NOUN
admet-557	51	29	at	at	ADP
admet-557	51	30	multiple	multiple	ADJ
admet-557	51	31	time	time	NOUN
admet-557	52	1	r.	r.	PROPN
admet-557	52	2	mullangi	mullangi	PROPN
admet-557	52	3	et	et	PROPN
admet-557	52	4	al	al	PROPN
admet-557	52	5	.	.	PROPN
admet-557	52	6	admet	admet	PROPN
admet-557	52	7	&	&	CCONJ
admet-557	52	8	dmpk	dmpk	PROPN
admet-557	52	9	6(3	6(3	PROPN
admet-557	52	10	)	)	PUNCT
admet-557	52	11	(	(	PUNCT
admet-557	52	12	2018	2018	NUM
admet-557	52	13	)	)	PUNCT
admet-557	52	14	242	242	NUM
admet-557	52	15	-	-	SYM
admet-557	52	16	257	257	NUM
admet-557	52	17	244	244	NUM
admet-557	52	18	points	point	NOUN
admet-557	52	19	.	.	PUNCT
admet-557	53	1	this	this	PRON
admet-557	53	2	will	will	AUX
admet-557	53	3	force	force	VERB
admet-557	53	4	researcher	researcher	NOUN
admet-557	53	5	to	to	PART
admet-557	53	6	adopt	adopt	VERB
admet-557	53	7	sparse	sparse	ADJ
admet-557	53	8	sampling	sampling	NOUN
admet-557	53	9	,	,	PUNCT
admet-557	53	10	which	which	PRON
admet-557	53	11	limits	limit	VERB
admet-557	53	12	the	the	DET
admet-557	53	13	researcher	researcher	NOUN
admet-557	53	14	to	to	PART
admet-557	53	15	study	study	VERB
admet-557	53	16	the	the	DET
admet-557	53	17	pharmacokinetics	pharmacokinetic	NOUN
admet-557	53	18	from	from	ADP
admet-557	53	19	individual	individual	ADJ
admet-557	53	20	animal	animal	NOUN
admet-557	53	21	/	/	SYM
admet-557	53	22	neonate	neonate	NOUN
admet-557	53	23	.	.	PUNCT
admet-557	54	1	traditional	traditional	ADJ
admet-557	54	2	samples	sample	NOUN
admet-557	54	3	are	be	AUX
admet-557	54	4	normally	normally	ADV
admet-557	54	5	shipped	ship	VERB
admet-557	54	6	on	on	ADP
admet-557	54	7	dry	dry	ADJ
admet-557	54	8	ice	ice	NOUN
admet-557	54	9	from	from	ADP
admet-557	54	10	one	one	NUM
admet-557	54	11	place	place	NOUN
admet-557	54	12	to	to	ADP
admet-557	54	13	other	other	ADJ
admet-557	54	14	,	,	PUNCT
admet-557	54	15	which	which	PRON
admet-557	54	16	incurs	incur	VERB
admet-557	54	17	shipping	shipping	NOUN
admet-557	54	18	and	and	CCONJ
admet-557	54	19	handling	handling	NOUN
admet-557	54	20	costs	cost	NOUN
admet-557	54	21	.	.	PUNCT
admet-557	55	1	over	over	ADP
admet-557	55	2	the	the	DET
admet-557	55	3	wet	wet	ADJ
admet-557	55	4	sampling	sampling	NOUN
admet-557	55	5	(	(	PUNCT
admet-557	55	6	blood	blood	NOUN
admet-557	55	7	/	/	SYM
admet-557	55	8	plasma	plasma	NOUN
admet-557	55	9	/	/	SYM
admet-557	55	10	serum	serum	NOUN
admet-557	55	11	)	)	PUNCT
admet-557	55	12	techniques	technique	NOUN
admet-557	55	13	,	,	PUNCT
admet-557	55	14	dried	dry	VERB
admet-557	55	15	blood	blood	NOUN
admet-557	55	16	spots	spot	NOUN
admet-557	55	17	(	(	PUNCT
admet-557	55	18	dbs	dbs	PROPN
admet-557	55	19	)	)	PUNCT
admet-557	55	20	method	method	NOUN
admet-557	55	21	offers	offer	VERB
admet-557	55	22	several	several	ADJ
admet-557	55	23	advantages	advantage	NOUN
admet-557	55	24	like	like	ADP
admet-557	55	25	reduced	reduce	VERB
admet-557	55	26	blood	blood	NOUN
admet-557	55	27	/	/	SYM
admet-557	55	28	plasma	plasma	NOUN
admet-557	55	29	/	/	SYM
admet-557	55	30	serum	serum	NOUN
admet-557	55	31	volume	volume	NOUN
admet-557	55	32	per	per	ADP
admet-557	55	33	time	time	NOUN
admet-557	55	34	point	point	NOUN
admet-557	55	35	,	,	PUNCT
admet-557	55	36	ease	ease	NOUN
admet-557	55	37	and	and	CCONJ
admet-557	55	38	safety	safety	NOUN
admet-557	55	39	in	in	ADP
admet-557	55	40	handling	handling	NOUN
admet-557	55	41	,	,	PUNCT
admet-557	55	42	potential	potential	ADJ
admet-557	55	43	cost	cost	NOUN
admet-557	55	44	saving	saving	NOUN
admet-557	55	45	in	in	ADP
admet-557	55	46	storage	storage	NOUN
admet-557	55	47	and	and	CCONJ
admet-557	55	48	shipment	shipment	NOUN
admet-557	55	49	at	at	ADP
admet-557	55	50	ambient	ambient	ADJ
admet-557	55	51	room	room	NOUN
admet-557	55	52	temperature	temperature	NOUN
admet-557	55	53	,	,	PUNCT
admet-557	55	54	less	less	ADJ
admet-557	55	55	sample	sample	NOUN
admet-557	55	56	processing	processing	NOUN
admet-557	55	57	time	time	NOUN
admet-557	55	58	and	and	CCONJ
admet-557	55	59	increase	increase	VERB
admet-557	55	60	in	in	ADP
admet-557	55	61	throughput	throughput	NOUN
admet-557	55	62	etc	etc	X
admet-557	55	63	.	.	PUNCT
admet-557	56	1	[	[	X
admet-557	56	2	24	24	NUM
admet-557	56	3	]	]	PUNCT
admet-557	56	4	.	.	PUNCT
admet-557	57	1	to	to	ADP
admet-557	57	2	the	the	DET
admet-557	57	3	best	good	ADJ
admet-557	57	4	of	of	ADP
admet-557	57	5	our	our	PRON
admet-557	57	6	knowledge	knowledge	NOUN
admet-557	57	7	,	,	PUNCT
admet-557	57	8	simultaneous	simultaneous	ADJ
admet-557	57	9	method	method	NOUN
admet-557	57	10	for	for	ADP
admet-557	57	11	the	the	DET
admet-557	57	12	determination	determination	NOUN
admet-557	57	13	of	of	ADP
admet-557	57	14	enzalutamide	enzalutamide	ADJ
admet-557	57	15	,	,	PUNCT
admet-557	57	16	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	57	17	,	,	PUNCT
admet-557	57	18	darolutamide	darolutamide	NOUN
admet-557	57	19	and	and	CCONJ
admet-557	57	20	orm-15341	orm-15341	NOUN
admet-557	57	21	on	on	ADP
admet-557	57	22	mice	mouse	NOUN
admet-557	57	23	dbs	dbs	PROPN
admet-557	57	24	has	have	AUX
admet-557	57	25	not	not	PART
admet-557	57	26	been	be	AUX
admet-557	57	27	reported	report	VERB
admet-557	57	28	in	in	ADP
admet-557	57	29	the	the	DET
admet-557	57	30	literature	literature	NOUN
admet-557	57	31	.	.	PUNCT
admet-557	58	1	for	for	ADP
admet-557	58	2	this	this	DET
admet-557	58	3	purpose	purpose	NOUN
admet-557	58	4	,	,	PUNCT
admet-557	58	5	the	the	DET
admet-557	58	6	present	present	ADJ
admet-557	58	7	study	study	NOUN
admet-557	58	8	is	be	AUX
admet-557	58	9	aimed	aim	VERB
admet-557	58	10	to	to	PART
admet-557	58	11	develop	develop	VERB
admet-557	58	12	and	and	CCONJ
admet-557	58	13	validate	validate	VERB
admet-557	58	14	a	a	DET
admet-557	58	15	simple	simple	ADJ
admet-557	58	16	and	and	CCONJ
admet-557	58	17	rapid	rapid	ADJ
admet-557	58	18	lcms	lcms	PROPN
admet-557	58	19	/	/	SYM
admet-557	58	20	ms	ms	PROPN
admet-557	58	21	method	method	NOUN
admet-557	58	22	for	for	ADP
admet-557	58	23	simultaneous	simultaneous	ADJ
admet-557	58	24	quantification	quantification	NOUN
admet-557	58	25	of	of	ADP
admet-557	58	26	enzalutamide	enzalutamide	NOUN
admet-557	58	27	,	,	PUNCT
admet-557	58	28	n	n	CCONJ
admet-557	58	29	-	-	PUNCT
admet-557	58	30	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	58	31	,	,	PUNCT
admet-557	58	32	darolutamide	darolutamide	NOUN
admet-557	58	33	and	and	CCONJ
admet-557	58	34	orm-15341	orm-15341	NOUN
admet-557	58	35	on	on	ADP
admet-557	58	36	mice	mouse	NOUN
admet-557	58	37	dbs	dbs	PROPN
admet-557	58	38	without	without	ADP
admet-557	58	39	compromising	compromise	VERB
admet-557	58	40	on	on	ADP
admet-557	58	41	sensitivity	sensitivity	NOUN
admet-557	58	42	.	.	PUNCT
admet-557	59	1	the	the	DET
admet-557	59	2	validated	validate	VERB
admet-557	59	3	method	method	NOUN
admet-557	59	4	was	be	AUX
admet-557	59	5	successfully	successfully	ADV
admet-557	59	6	used	use	VERB
admet-557	59	7	in	in	ADP
admet-557	59	8	a	a	DET
admet-557	59	9	mice	mice	NOUN
admet-557	59	10	pharmacokinetic	pharmacokinetic	ADJ
admet-557	59	11	study	study	NOUN
admet-557	59	12	following	follow	VERB
admet-557	59	13	intravenous	intravenous	ADJ
admet-557	59	14	administration	administration	NOUN
admet-557	59	15	of	of	ADP
admet-557	59	16	enzalutamide	enzalutamide	ADV
admet-557	59	17	and	and	CCONJ
admet-557	59	18	darolutamide	darolutamide	ADV
admet-557	59	19	at	at	ADP
admet-557	59	20	1.0	1.0	NUM
admet-557	59	21	mg	mg	PROPN
admet-557	59	22	/	/	SYM
admet-557	59	23	kg	kg	PROPN
admet-557	59	24	dose	dose	NOUN
admet-557	59	25	.	.	PUNCT
admet-557	60	1	materials	material	NOUN
admet-557	60	2	and	and	CCONJ
admet-557	60	3	methods	method	NOUN
admet-557	60	4	materials	material	NOUN
admet-557	60	5	enzalutamide	enzalutamide	ADV
admet-557	60	6	(	(	PUNCT
admet-557	60	7	purity	purity	NOUN
admet-557	60	8	:	:	PUNCT
admet-557	60	9	>	>	PUNCT
admet-557	60	10	98.3	98.3	NUM
admet-557	60	11	%	%	NOUN
admet-557	60	12	)	)	PUNCT
admet-557	60	13	and	and	CCONJ
admet-557	60	14	n	n	CCONJ
admet-557	60	15	-	-	PUNCT
admet-557	60	16	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	60	17	(	(	PUNCT
admet-557	60	18	purity	purity	NOUN
admet-557	60	19	:	:	PUNCT
admet-557	60	20	>	>	PUNCT
admet-557	60	21	99.6	99.6	NUM
admet-557	60	22	%	%	NOUN
admet-557	60	23	)	)	PUNCT
admet-557	60	24	were	be	AUX
admet-557	60	25	purchased	purchase	VERB
admet-557	60	26	from	from	ADP
admet-557	60	27	bioorganics	bioorganic	NOUN
admet-557	60	28	,	,	PUNCT
admet-557	60	29	bangalore	bangalore	PROPN
admet-557	60	30	,	,	PUNCT
admet-557	60	31	india	india	PROPN
admet-557	60	32	.	.	PROPN
admet-557	61	1	darolutamide	darolutamide	PROPN
admet-557	61	2	(	(	PUNCT
admet-557	61	3	purity	purity	NOUN
admet-557	61	4	:	:	PUNCT
admet-557	61	5	98	98	NUM
admet-557	61	6	%	%	NOUN
admet-557	61	7	)	)	PUNCT
admet-557	61	8	was	be	AUX
admet-557	61	9	procured	procure	VERB
admet-557	61	10	from	from	ADP
admet-557	61	11	angene	angene	PROPN
admet-557	61	12	international	international	PROPN
admet-557	61	13	limited	limited	PROPN
admet-557	61	14	,	,	PUNCT
admet-557	61	15	china	china	PROPN
admet-557	61	16	.	.	PROPN
admet-557	61	17	orm-15341	orm-15341	PROPN
admet-557	61	18	(	(	PUNCT
admet-557	61	19	purity	purity	NOUN
admet-557	61	20	:	:	PUNCT
admet-557	61	21	99.4	99.4	NUM
admet-557	61	22	%	%	NOUN
admet-557	61	23	)	)	PUNCT
admet-557	61	24	and	and	CCONJ
admet-557	61	25	apalutamide	apalutamide	NOUN
admet-557	61	26	-	-	PUNCT
admet-557	61	27	d3	d3	PROPN
admet-557	61	28	(	(	PUNCT
admet-557	61	29	purity	purity	NOUN
admet-557	61	30	:	:	PUNCT
admet-557	61	31	99.5	99.5	NUM
admet-557	61	32	%	%	NOUN
admet-557	61	33	;	;	PUNCT
admet-557	61	34	fig	fig	NOUN
admet-557	61	35	.	.	NOUN
admet-557	62	1	1	1	NUM
admet-557	62	2	)	)	PUNCT
admet-557	62	3	were	be	AUX
admet-557	62	4	synthesized	synthesize	VERB
admet-557	62	5	by	by	ADP
admet-557	62	6	the	the	DET
admet-557	62	7	medicinal	medicinal	ADJ
admet-557	62	8	chemistry	chemistry	NOUN
admet-557	62	9	group	group	NOUN
admet-557	62	10	,	,	PUNCT
admet-557	62	11	jubilant	jubilant	ADJ
admet-557	62	12	biosys	biosys	NOUN
admet-557	62	13	(	(	PUNCT
admet-557	62	14	bangalore	bangalore	PROPN
admet-557	62	15	,	,	PUNCT
admet-557	62	16	india	india	PROPN
admet-557	62	17	)	)	PUNCT
admet-557	62	18	using	use	VERB
admet-557	62	19	literature	literature	NOUN
admet-557	62	20	information	information	NOUN
admet-557	63	1	[	[	X
admet-557	63	2	25,26	25,26	X
admet-557	63	3	]	]	PUNCT
admet-557	63	4	and	and	CCONJ
admet-557	63	5	characterized	characterize	VERB
admet-557	63	6	using	use	VERB
admet-557	63	7	chromatographic	chromatographic	ADJ
admet-557	63	8	(	(	PUNCT
admet-557	63	9	hplc	hplc	NOUN
admet-557	63	10	,	,	PUNCT
admet-557	63	11	lc	lc	PROPN
admet-557	63	12	-	-	PUNCT
admet-557	63	13	ms	ms	PROPN
admet-557	63	14	/	/	SYM
admet-557	63	15	ms	ms	PROPN
admet-557	63	16	)	)	PUNCT
admet-557	63	17	and	and	CCONJ
admet-557	63	18	spectral	spectral	ADJ
admet-557	63	19	techniques	technique	NOUN
admet-557	63	20	(	(	PUNCT
admet-557	63	21	ir	ir	NOUN
admet-557	63	22	,	,	PUNCT
admet-557	63	23	uv	uv	PROPN
admet-557	63	24	,	,	PUNCT
admet-557	63	25	mass	mass	PROPN
admet-557	63	26	,	,	PUNCT
admet-557	63	27	1h	1h	NUM
admet-557	63	28	and	and	CCONJ
admet-557	63	29	13c	13c	NOUN
admet-557	63	30	-	-	NOUN
admet-557	63	31	nmr	nmr	NOUN
admet-557	63	32	)	)	PUNCT
admet-557	63	33	by	by	ADP
admet-557	63	34	the	the	DET
admet-557	63	35	analytical	analytical	ADJ
admet-557	63	36	research	research	NOUN
admet-557	63	37	group	group	NOUN
admet-557	63	38	,	,	PUNCT
admet-557	63	39	jubilant	jubilant	ADJ
admet-557	63	40	biosys	biosys	NOUN
admet-557	63	41	.	.	PUNCT
admet-557	64	1	hplc	hplc	NOUN
admet-557	64	2	-	-	PUNCT
admet-557	64	3	grade	grade	NOUN
admet-557	64	4	acetonitrile	acetonitrile	NOUN
admet-557	64	5	,	,	PUNCT
admet-557	64	6	methanol	methanol	NOUN
admet-557	64	7	,	,	PUNCT
admet-557	64	8	methyl	methyl	NOUN
admet-557	64	9	tert	tert	NOUN
admet-557	64	10	-	-	PUNCT
admet-557	64	11	butyl	butyl	NOUN
admet-557	64	12	ether	ether	NOUN
admet-557	64	13	(	(	PUNCT
admet-557	64	14	tbme	tbme	NOUN
admet-557	64	15	)	)	PUNCT
admet-557	64	16	and	and	CCONJ
admet-557	64	17	ethyl	ethyl	PROPN
admet-557	64	18	acetate	acetate	PROPN
admet-557	64	19	were	be	AUX
admet-557	64	20	purchased	purchase	VERB
admet-557	64	21	from	from	ADP
admet-557	64	22	rankem	rankem	PROPN
admet-557	64	23	,	,	PUNCT
admet-557	64	24	new	new	ADJ
admet-557	64	25	delhi	delhi	PROPN
admet-557	64	26	,	,	PUNCT
admet-557	64	27	india	india	PROPN
admet-557	64	28	.	.	PUNCT
admet-557	65	1	whatman	whatman	PROPN
admet-557	65	2	fta	fta	PROPN
admet-557	65	3	dmpk	dmpk	PROPN
admet-557	65	4	card	card	PROPN
admet-557	65	5	c	c	PROPN
admet-557	65	6	dbs	dbs	PROPN
admet-557	65	7	cards	card	NOUN
admet-557	65	8	were	be	AUX
admet-557	65	9	purchased	purchase	VERB
admet-557	65	10	from	from	ADP
admet-557	65	11	ge	ge	PROPN
admet-557	65	12	,	,	PUNCT
admet-557	65	13	bangalore	bangalore	PROPN
admet-557	65	14	.	.	PUNCT
admet-557	66	1	silica	silica	NOUN
admet-557	66	2	gel	gel	NOUN
admet-557	66	3	sachets	sachet	NOUN
admet-557	66	4	and	and	CCONJ
admet-557	66	5	sealable	sealable	ADJ
admet-557	66	6	plastic	plastic	NOUN
admet-557	66	7	bags	bag	NOUN
admet-557	66	8	for	for	ADP
admet-557	66	9	the	the	DET
admet-557	66	10	storage	storage	NOUN
admet-557	66	11	of	of	ADP
admet-557	66	12	dbs	dbs	PROPN
admet-557	66	13	cards	card	NOUN
admet-557	66	14	were	be	AUX
admet-557	66	15	purchased	purchase	VERB
admet-557	66	16	from	from	ADP
admet-557	66	17	local	local	ADJ
admet-557	66	18	market	market	NOUN
admet-557	66	19	.	.	PUNCT
admet-557	67	1	instrumentation	instrumentation	NOUN
admet-557	67	2	and	and	CCONJ
admet-557	67	3	chromatographic	chromatographic	ADJ
admet-557	67	4	conditions	condition	NOUN
admet-557	67	5	a	a	DET
admet-557	67	6	shimadzu	shimadzu	ADJ
admet-557	67	7	vp	vp	PROPN
admet-557	67	8	(	(	PUNCT
admet-557	67	9	shimadzu	shimadzu	PROPN
admet-557	67	10	,	,	PUNCT
admet-557	67	11	japan	japan	PROPN
admet-557	67	12	)	)	PUNCT
admet-557	67	13	lc	lc	PROPN
admet-557	67	14	system	system	NOUN
admet-557	67	15	equipped	equip	VERB
admet-557	67	16	with	with	ADP
admet-557	67	17	degasser	degasser	PROPN
admet-557	67	18	(	(	PUNCT
admet-557	67	19	g1379a	g1379a	NOUN
admet-557	67	20	)	)	PUNCT
admet-557	67	21	,	,	PUNCT
admet-557	67	22	quaternary	quaternary	ADJ
admet-557	67	23	pump	pump	NOUN
admet-557	67	24	(	(	PUNCT
admet-557	67	25	10advp	10advp	NUM
admet-557	67	26	)	)	PUNCT
admet-557	67	27	,	,	PUNCT
admet-557	67	28	column	column	NOUN
admet-557	67	29	oven	oven	PROPN
admet-557	67	30	(	(	PUNCT
admet-557	67	31	cto-10asvp	cto-10asvp	PROPN
admet-557	67	32	)	)	PUNCT
admet-557	67	33	,	,	PUNCT
admet-557	67	34	auto	auto	NOUN
admet-557	67	35	-	-	PUNCT
admet-557	67	36	sampler	sampler	NOUN
admet-557	67	37	(	(	PUNCT
admet-557	67	38	sil	sil	PROPN
admet-557	67	39	-	-	PUNCT
admet-557	67	40	htc	htc	NOUN
admet-557	67	41	)	)	PUNCT
admet-557	67	42	along	along	ADP
admet-557	67	43	with	with	ADP
admet-557	67	44	system	system	NOUN
admet-557	67	45	controller	controller	NOUN
admet-557	67	46	(	(	PUNCT
admet-557	67	47	scl-10avp	scl-10avp	PROPN
admet-557	67	48	)	)	PUNCT
admet-557	67	49	was	be	AUX
admet-557	67	50	used	use	VERB
admet-557	67	51	to	to	PART
admet-557	67	52	inject	inject	VERB
admet-557	67	53	5.0	5.0	NUM
admet-557	67	54	µl	µl	ADP
admet-557	67	55	aliquots	aliquot	NOUN
admet-557	67	56	of	of	ADP
admet-557	67	57	the	the	DET
admet-557	67	58	processed	process	VERB
admet-557	67	59	samples	sample	NOUN
admet-557	67	60	on	on	ADP
admet-557	67	61	an	an	DET
admet-557	67	62	atlantis	atlantis	PROPN
admet-557	67	63	dc18	dc18	PROPN
admet-557	67	64	column	column	NOUN
admet-557	67	65	(	(	PUNCT
admet-557	67	66	50	50	NUM
admet-557	67	67	x	x	SYM
admet-557	67	68	4.6	4.6	NUM
admet-557	67	69	mm	mm	NOUN
admet-557	67	70	,	,	PUNCT
admet-557	67	71	3	3	NUM
admet-557	67	72	µm	µm	NOUN
admet-557	67	73	;	;	PUNCT
admet-557	67	74	waters	water	NOUN
admet-557	67	75	,	,	PUNCT
admet-557	67	76	milford	milford	PROPN
admet-557	67	77	,	,	PUNCT
admet-557	67	78	ma	ma	PROPN
admet-557	67	79	,	,	PUNCT
admet-557	67	80	usa	usa	PROPN
admet-557	67	81	)	)	PUNCT
admet-557	67	82	,	,	PUNCT
admet-557	67	83	which	which	PRON
admet-557	67	84	was	be	AUX
admet-557	67	85	kept	keep	VERB
admet-557	67	86	at	at	ADP
admet-557	67	87	ambient	ambient	ADJ
admet-557	67	88	temperature	temperature	NOUN
admet-557	67	89	(	(	PUNCT
admet-557	67	90	24	24	NUM
admet-557	67	91	±	±	NUM
admet-557	67	92	1	1	NUM
admet-557	67	93	°	°	ADP
admet-557	67	94	c	c	NOUN
admet-557	67	95	)	)	PUNCT
admet-557	67	96	.	.	PUNCT
admet-557	68	1	the	the	DET
admet-557	68	2	isocratic	isocratic	ADJ
admet-557	68	3	mobile	mobile	ADJ
admet-557	68	4	phase	phase	NOUN
admet-557	68	5	,	,	PUNCT
admet-557	68	6	a	a	DET
admet-557	68	7	mixture	mixture	NOUN
admet-557	68	8	of	of	ADP
admet-557	68	9	0.2	0.2	NUM
admet-557	68	10	%	%	NOUN
admet-557	68	11	formic	formic	ADJ
admet-557	68	12	acid	acid	NOUN
admet-557	68	13	:	:	PUNCT
admet-557	68	14	acetonitrile	acetonitrile	NOUN
admet-557	68	15	(	(	PUNCT
admet-557	68	16	30:70	30:70	NUM
admet-557	68	17	,	,	PUNCT
admet-557	68	18	v	v	NOUN
admet-557	68	19	/	/	SYM
admet-557	68	20	v	v	NOUN
admet-557	68	21	)	)	PUNCT
admet-557	68	22	was	be	AUX
admet-557	68	23	filtered	filter	VERB
admet-557	68	24	through	through	ADP
admet-557	68	25	a	a	DET
admet-557	68	26	0.45	0.45	NUM
admet-557	68	27	µm	µm	ADP
admet-557	68	28	membrane	membrane	NOUN
admet-557	68	29	filter	filter	NOUN
admet-557	68	30	(	(	PUNCT
admet-557	68	31	xi5522050	xi5522050	PROPN
admet-557	68	32	)	)	PUNCT
admet-557	68	33	(	(	PUNCT
admet-557	68	34	millipore	millipore	PROPN
admet-557	68	35	,	,	PUNCT
admet-557	68	36	usa	usa	PROPN
admet-557	68	37	or	or	CCONJ
admet-557	68	38	equivalent	equivalent	ADJ
admet-557	68	39	)	)	PUNCT
admet-557	68	40	and	and	CCONJ
admet-557	68	41	then	then	ADV
admet-557	68	42	degassed	degas	VERB
admet-557	68	43	ultrasonically	ultrasonically	NOUN
admet-557	68	44	for	for	SCONJ
admet-557	68	45	5	5	NUM
admet-557	68	46	min	min	NOUN
admet-557	68	47	was	be	AUX
admet-557	68	48	delivered	deliver	VERB
admet-557	68	49	at	at	ADP
admet-557	68	50	a	a	DET
admet-557	68	51	flow	flow	NOUN
admet-557	68	52	rate	rate	NOUN
admet-557	68	53	of	of	ADP
admet-557	68	54	0.8	0.8	NUM
admet-557	68	55	ml	ml	NOUN
admet-557	68	56	/	/	SYM
admet-557	68	57	min	min	NOUN
admet-557	68	58	(	(	PUNCT
admet-557	68	59	with	with	ADP
admet-557	68	60	splitter	splitter	NOUN
admet-557	68	61	50	50	NUM
admet-557	68	62	%	%	NOUN
admet-557	68	63	)	)	PUNCT
admet-557	68	64	into	into	ADP
admet-557	68	65	the	the	DET
admet-557	68	66	mass	mass	NOUN
admet-557	68	67	spectrometer	spectrometer	NOUN
admet-557	68	68	electro	electro	NOUN
admet-557	68	69	spray	spray	VERB
admet-557	68	70	ionization	ionization	NOUN
admet-557	68	71	chamber	chamber	PROPN
admet-557	68	72	.	.	PUNCT
admet-557	69	1	quantitation	quantitation	NOUN
admet-557	69	2	was	be	AUX
admet-557	69	3	achieved	achieve	VERB
admet-557	69	4	by	by	ADP
admet-557	69	5	ms	ms	PROPN
admet-557	69	6	/	/	SYM
admet-557	69	7	ms	ms	PROPN
admet-557	69	8	detection	detection	NOUN
admet-557	69	9	in	in	ADP
admet-557	69	10	positive	positive	ADJ
admet-557	69	11	ion	ion	NOUN
admet-557	69	12	mode	mode	NOUN
admet-557	69	13	for	for	ADP
admet-557	69	14	the	the	DET
admet-557	69	15	analytes	analyte	NOUN
admet-557	69	16	and	and	CCONJ
admet-557	69	17	the	the	PRON
admet-557	69	18	is	be	AUX
admet-557	69	19	using	use	VERB
admet-557	69	20	sciex	sciex	NOUN
admet-557	69	21	(	(	PUNCT
admet-557	69	22	foster	foster	ADJ
admet-557	69	23	city	city	NOUN
admet-557	69	24	,	,	PUNCT
admet-557	69	25	ca	ca	PROPN
admet-557	69	26	,	,	PUNCT
admet-557	69	27	usa	usa	PROPN
admet-557	69	28	)	)	PUNCT
admet-557	69	29	api-6500	api-6500	NOUN
admet-557	69	30	mass	mass	PROPN
admet-557	69	31	spectrometer	spectrometer	NOUN
admet-557	69	32	,	,	PUNCT
admet-557	69	33	equipped	equip	VERB
admet-557	69	34	with	with	ADP
admet-557	69	35	a	a	DET
admet-557	69	36	turboionspray	turboionspray	PROPN
admet-557	69	37	interface	interface	NOUN
admet-557	69	38	at	at	ADP
admet-557	69	39	500	500	NUM
admet-557	69	40	°	°	NOUN
admet-557	69	41	c	c	NOUN
admet-557	69	42	and	and	CCONJ
admet-557	69	43	5500	5500	NUM
admet-557	69	44	v	v	NOUN
admet-557	69	45	ion	ion	NOUN
admet-557	69	46	spray	spray	NOUN
admet-557	69	47	voltage	voltage	NOUN
admet-557	69	48	.	.	PUNCT
admet-557	70	1	the	the	DET
admet-557	70	2	common	common	ADJ
admet-557	70	3	parameters	parameter	NOUN
admet-557	70	4	,	,	PUNCT
admet-557	70	5	i.e.	i.e.	X
admet-557	70	6	curtain	curtain	NOUN
admet-557	70	7	gas	gas	NOUN
admet-557	70	8	(	(	PUNCT
admet-557	70	9	cur	cur	PROPN
admet-557	70	10	)	)	PUNCT
admet-557	70	11	,	,	PUNCT
admet-557	70	12	nebulizer	nebulizer	NOUN
admet-557	70	13	gas	gas	NOUN
admet-557	70	14	(	(	PUNCT
admet-557	70	15	gs1	gs1	NOUN
admet-557	70	16	)	)	PUNCT
admet-557	70	17	,	,	PUNCT
admet-557	70	18	auxiliary	auxiliary	ADJ
admet-557	70	19	gas	gas	NOUN
admet-557	70	20	(	(	PUNCT
admet-557	70	21	gs2	gs2	NOUN
admet-557	70	22	)	)	PUNCT
admet-557	70	23	and	and	CCONJ
admet-557	70	24	collision	collision	NOUN
admet-557	70	25	gas	gas	NOUN
admet-557	70	26	(	(	PUNCT
admet-557	70	27	cad	cad	NOUN
admet-557	70	28	)	)	PUNCT
admet-557	70	29	were	be	AUX
admet-557	70	30	set	set	VERB
admet-557	70	31	at	at	ADP
admet-557	70	32	55	55	NUM
admet-557	70	33	,	,	PUNCT
admet-557	70	34	55	55	NUM
admet-557	70	35	,	,	PUNCT
admet-557	70	36	65	65	NUM
admet-557	70	37	and	and	CCONJ
admet-557	70	38	10	10	NUM
admet-557	70	39	psi	psi	NOUN
admet-557	70	40	,	,	PUNCT
admet-557	70	41	respectively	respectively	ADV
admet-557	70	42	.	.	PUNCT
admet-557	71	1	the	the	DET
admet-557	71	2	compounds	compound	NOUN
admet-557	71	3	parameters	parameter	NOUN
admet-557	71	4	,	,	PUNCT
admet-557	71	5	i.e.	i.e.	X
admet-557	71	6	declustering	declustere	VERB
admet-557	71	7	potential	potential	ADJ
admet-557	71	8	(	(	PUNCT
admet-557	71	9	dp	dp	NOUN
admet-557	71	10	)	)	PUNCT
admet-557	71	11	,	,	PUNCT
admet-557	71	12	collision	collision	NOUN
admet-557	71	13	energy	energy	NOUN
admet-557	71	14	(	(	PUNCT
admet-557	71	15	ce	ce	PROPN
admet-557	71	16	)	)	PUNCT
admet-557	71	17	,	,	PUNCT
admet-557	71	18	collision	collision	NOUN
admet-557	71	19	exit	exit	NOUN
admet-557	71	20	potential	potential	NOUN
admet-557	71	21	(	(	PUNCT
admet-557	71	22	cxp	cxp	PROPN
admet-557	71	23	)	)	PUNCT
admet-557	71	24	and	and	CCONJ
admet-557	71	25	entrance	entrance	NOUN
admet-557	71	26	potential	potential	NOUN
admet-557	71	27	(	(	PUNCT
admet-557	71	28	ep	ep	PROPN
admet-557	71	29	)	)	PUNCT
admet-557	71	30	for	for	ADP
admet-557	71	31	the	the	DET
admet-557	71	32	analytes	analyte	NOUN
admet-557	71	33	and	and	CCONJ
admet-557	71	34	the	the	PRON
admet-557	71	35	is	be	AUX
admet-557	71	36	are	be	AUX
admet-557	71	37	shown	show	VERB
admet-557	71	38	in	in	ADP
admet-557	71	39	table	table	NOUN
admet-557	71	40	1	1	NUM
admet-557	71	41	.	.	PUNCT
admet-557	72	1	the	the	DET
admet-557	72	2	dwell	dwell	NOUN
admet-557	72	3	time	time	NOUN
admet-557	72	4	was	be	AUX
admet-557	72	5	100	100	NUM
admet-557	72	6	msec	msec	NOUN
admet-557	72	7	.	.	PUNCT
admet-557	73	1	quantitation	quantitation	NOUN
admet-557	73	2	of	of	ADP
admet-557	73	3	enzalutamide	enzalutamide	NOUN
admet-557	73	4	,	,	PUNCT
admet-557	73	5	n	n	CCONJ
admet-557	73	6	-	-	PUNCT
admet-557	73	7	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	73	8	,	,	PUNCT
admet-557	73	9	darolutamide	darolutamide	NOUN
admet-557	73	10	,	,	PUNCT
admet-557	73	11	orm-15341	orm-15341	NOUN
admet-557	73	12	and	and	CCONJ
admet-557	73	13	the	the	DET
admet-557	73	14	is	be	AUX
admet-557	73	15	was	be	AUX
admet-557	73	16	achieved	achieve	VERB
admet-557	73	17	by	by	ADP
admet-557	73	18	admet	admet	PROPN
admet-557	73	19	&	&	CCONJ
admet-557	73	20	dmpk	dmpk	PROPN
admet-557	73	21	6(3	6(3	PROPN
admet-557	73	22	)	)	PUNCT
admet-557	73	23	(	(	PUNCT
admet-557	73	24	2018	2018	NUM
admet-557	73	25	)	)	PUNCT
admet-557	73	26	242	242	NUM
admet-557	73	27	-	-	SYM
admet-557	73	28	257	257	NUM
admet-557	73	29	lc	lc	PROPN
admet-557	73	30	-	-	PUNCT
admet-557	73	31	ms	ms	PROPN
admet-557	73	32	/	/	SYM
admet-557	73	33	ms	ms	NOUN
admet-557	73	34	determination	determination	NOUN
admet-557	73	35	of	of	ADP
admet-557	73	36	enzalutamide	enzalutamide	ADV
admet-557	73	37	/	/	SYM
admet-557	73	38	darolutamide	darolutamide	NOUN
admet-557	73	39	with	with	ADP
admet-557	73	40	metabolites	metabolite	NOUN
admet-557	73	41	on	on	ADP
admet-557	73	42	dbs	dbs	PROPN
admet-557	73	43	doi	doi	PROPN
admet-557	73	44	:	:	PUNCT
admet-557	73	45	10.5599	10.5599	NUM
admet-557	73	46	/	/	SYM
admet-557	73	47	admet.557	admet.557	PROPN
admet-557	73	48	245	245	NUM
admet-557	73	49	monitoring	monitor	VERB
admet-557	73	50	the	the	DET
admet-557	73	51	precursor	precursor	NOUN
admet-557	73	52	q1	q1	PROPN
admet-557	73	53	→	→	SYM
admet-557	73	54	q3	q3	NOUN
admet-557	73	55	ions	ion	NOUN
admet-557	73	56	at	at	ADP
admet-557	73	57	m	m	PROPN
admet-557	73	58	/	/	SYM
admet-557	73	59	z	z	PROPN
admet-557	73	60	465→209	465→209	NOUN
admet-557	73	61	,	,	PUNCT
admet-557	73	62	451→195	451→195	PROPN
admet-557	73	63	,	,	PUNCT
admet-557	73	64	399→178	399→178	PROPN
admet-557	73	65	,	,	PUNCT
admet-557	73	66	397→194	397→194	NUM
admet-557	73	67	and	and	CCONJ
admet-557	73	68	481→453	481→453	NOUN
admet-557	73	69	,	,	PUNCT
admet-557	73	70	respectively	respectively	ADV
admet-557	73	71	.	.	PUNCT
admet-557	74	1	both	both	PRON
admet-557	74	2	q1	q1	PROPN
admet-557	74	3	and	and	CCONJ
admet-557	74	4	q3	q3	PROPN
admet-557	74	5	quadruples	quadruple	NOUN
admet-557	74	6	were	be	AUX
admet-557	74	7	set	set	VERB
admet-557	74	8	on	on	ADP
admet-557	74	9	unit	unit	NOUN
admet-557	74	10	resolution	resolution	NOUN
admet-557	74	11	.	.	PUNCT
admet-557	75	1	the	the	DET
admet-557	75	2	analytical	analytical	ADJ
admet-557	75	3	data	datum	NOUN
admet-557	75	4	was	be	AUX
admet-557	75	5	processed	process	VERB
admet-557	75	6	by	by	ADP
admet-557	75	7	analyst	analyst	NOUN
admet-557	75	8	software	software	NOUN
admet-557	75	9	(	(	PUNCT
admet-557	75	10	version	version	NOUN
admet-557	75	11	1.6.2	1.6.2	NUM
admet-557	75	12	)	)	PUNCT
admet-557	75	13	.	.	PUNCT
admet-557	76	1	table	table	NOUN
admet-557	76	2	1	1	NUM
admet-557	76	3	.	.	PUNCT
admet-557	76	4	optimized	optimize	VERB
admet-557	76	5	mass	mass	NOUN
admet-557	76	6	spectrometry	spectrometry	NOUN
admet-557	76	7	parameters	parameter	NOUN
admet-557	76	8	for	for	ADP
admet-557	76	9	analytes	analyte	NOUN
admet-557	76	10	and	and	CCONJ
admet-557	76	11	the	the	PRON
admet-557	76	12	is	be	AUX
admet-557	76	13	in	in	ADP
admet-557	76	14	volts	volts	NOUN
admet-557	76	15	analyte	analyte	NOUN
admet-557	76	16	dp	dp	PROPN
admet-557	76	17	ep	ep	PROPN
admet-557	76	18	ce	ce	PROPN
admet-557	76	19	cxp	cxp	PROPN
admet-557	76	20	enzalutamide	enzalutamide	ADV
admet-557	76	21	80	80	NUM
admet-557	76	22	10	10	NUM
admet-557	76	23	41	41	NUM
admet-557	76	24	12	12	NUM
admet-557	76	25	n	n	CCONJ
admet-557	76	26	-	-	PUNCT
admet-557	76	27	desmethylenzalutamide	desmethylenzalutamide	NOUN
admet-557	76	28	80	80	NUM
admet-557	76	29	10	10	NUM
admet-557	76	30	41	41	NUM
admet-557	76	31	12	12	NUM
admet-557	76	32	darolutamide	darolutamide	NOUN
admet-557	76	33	91	91	NUM
admet-557	76	34	10	10	NUM
admet-557	76	35	31	31	NUM
admet-557	76	36	30	30	NUM
admet-557	76	37	orm-15341	orm-15341	NOUN
admet-557	77	1	60	60	NUM
admet-557	77	2	10	10	NUM
admet-557	77	3	27	27	NUM
admet-557	77	4	12	12	NUM
admet-557	77	5	apalutamide	apalutamide	NOUN
admet-557	77	6	-	-	PUNCT
admet-557	77	7	d3	d3	PROPN
admet-557	77	8	(	(	PUNCT
admet-557	77	9	is	be	AUX
admet-557	77	10	)	)	PUNCT
admet-557	77	11	100	100	NUM
admet-557	77	12	10	10	NUM
admet-557	77	13	33	33	NUM
admet-557	77	14	12	12	NUM
admet-557	77	15	dp	dp	NOUN
admet-557	77	16	:	:	PUNCT
admet-557	77	17	declustering	declustere	VERB
admet-557	77	18	potential	potential	NOUN
admet-557	77	19	;	;	PUNCT
admet-557	77	20	ep	ep	NOUN
admet-557	77	21	:	:	PUNCT
admet-557	77	22	entrance	entrance	NOUN
admet-557	77	23	potential	potential	NOUN
admet-557	77	24	;	;	PUNCT
admet-557	77	25	ce	ce	PROPN
admet-557	77	26	:	:	PUNCT
admet-557	77	27	collision	collision	VERB
admet-557	77	28	energy	energy	NOUN
admet-557	77	29	and	and	CCONJ
admet-557	77	30	cxp	cxp	PROPN
admet-557	77	31	:	:	PUNCT
admet-557	77	32	collision	collision	NOUN
admet-557	77	33	cell	cell	NOUN
admet-557	77	34	exit	exit	NOUN
admet-557	77	35	potential	potential	ADJ
admet-557	77	36	preparation	preparation	NOUN
admet-557	77	37	of	of	ADP
admet-557	77	38	stock	stock	NOUN
admet-557	77	39	and	and	CCONJ
admet-557	77	40	standard	standard	ADJ
admet-557	77	41	solutions	solution	NOUN
admet-557	77	42	primary	primary	ADJ
admet-557	77	43	stock	stock	NOUN
admet-557	77	44	solutions	solution	NOUN
admet-557	77	45	of	of	ADP
admet-557	77	46	enzalutamide	enzalutamide	NOUN
admet-557	77	47	,	,	PUNCT
admet-557	77	48	n	n	CCONJ
admet-557	77	49	-	-	PUNCT
admet-557	77	50	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	77	51	,	,	PUNCT
admet-557	77	52	darolutamide	darolutamide	NOUN
admet-557	77	53	and	and	CCONJ
admet-557	77	54	orm-15341	orm-15341	NOUN
admet-557	77	55	for	for	ADP
admet-557	77	56	preparation	preparation	NOUN
admet-557	77	57	of	of	ADP
admet-557	77	58	calibration	calibration	NOUN
admet-557	77	59	curve	curve	NOUN
admet-557	77	60	(	(	PUNCT
admet-557	77	61	cc	cc	NOUN
admet-557	77	62	)	)	PUNCT
admet-557	77	63	and	and	CCONJ
admet-557	77	64	quality	quality	NOUN
admet-557	77	65	control	control	NOUN
admet-557	77	66	(	(	PUNCT
admet-557	77	67	qc	qc	PROPN
admet-557	77	68	)	)	PUNCT
admet-557	77	69	samples	sample	NOUN
admet-557	77	70	were	be	AUX
admet-557	77	71	prepared	prepare	VERB
admet-557	77	72	from	from	ADP
admet-557	77	73	separate	separate	ADJ
admet-557	77	74	weighing	weighing	NOUN
admet-557	77	75	.	.	PUNCT
admet-557	78	1	individual	individual	ADJ
admet-557	78	2	primary	primary	ADJ
admet-557	78	3	stock	stock	NOUN
admet-557	78	4	solution	solution	NOUN
admet-557	78	5	of	of	ADP
admet-557	78	6	all	all	DET
admet-557	78	7	the	the	DET
admet-557	78	8	analytes	analyte	NOUN
admet-557	78	9	at	at	ADP
admet-557	78	10	200	200	NUM
admet-557	78	11	µg	µg	NOUN
admet-557	78	12	/	/	SYM
admet-557	78	13	ml	ml	NOUN
admet-557	78	14	were	be	AUX
admet-557	78	15	prepared	prepare	VERB
admet-557	78	16	in	in	ADP
admet-557	78	17	dmso	dmso	NOUN
admet-557	78	18	:	:	PUNCT
admet-557	78	19	methanol	methanol	NOUN
admet-557	78	20	(	(	PUNCT
admet-557	78	21	0.2:99.8	0.2:99.8	NUM
admet-557	78	22	,	,	PUNCT
admet-557	78	23	v	v	NOUN
admet-557	78	24	/	/	SYM
admet-557	78	25	v	v	NOUN
admet-557	78	26	)	)	PUNCT
admet-557	78	27	.	.	PUNCT
admet-557	79	1	similarly	similarly	ADV
admet-557	79	2	the	the	DET
admet-557	79	3	primary	primary	ADJ
admet-557	79	4	stock	stock	NOUN
admet-557	79	5	solution	solution	NOUN
admet-557	79	6	of	of	ADP
admet-557	79	7	the	the	DET
admet-557	79	8	is	is	NOUN
admet-557	79	9	(	(	PUNCT
admet-557	79	10	200	200	NUM
admet-557	79	11	µg	µg	NOUN
admet-557	79	12	/	/	SYM
admet-557	79	13	ml	ml	NOUN
admet-557	79	14	)	)	PUNCT
admet-557	79	15	was	be	AUX
admet-557	79	16	prepared	prepare	VERB
admet-557	79	17	in	in	ADP
admet-557	79	18	methanol	methanol	NOUN
admet-557	79	19	.	.	PUNCT
admet-557	80	1	the	the	DET
admet-557	80	2	primary	primary	ADJ
admet-557	80	3	stock	stock	NOUN
admet-557	80	4	solutions	solution	NOUN
admet-557	80	5	of	of	ADP
admet-557	80	6	enzalutamide	enzalutamide	NOUN
admet-557	80	7	,	,	PUNCT
admet-557	80	8	n	n	CCONJ
admet-557	80	9	-	-	PUNCT
admet-557	80	10	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	80	11	,	,	PUNCT
admet-557	80	12	darolutamide	darolutamide	NOUN
admet-557	80	13	,	,	PUNCT
admet-557	80	14	orm15341	orm15341	NOUN
admet-557	80	15	and	and	CCONJ
admet-557	80	16	the	the	DET
admet-557	80	17	is	be	AUX
admet-557	80	18	were	be	AUX
admet-557	80	19	stored	store	VERB
admet-557	80	20	at	at	ADP
admet-557	80	21	-20	-20	PROPN
admet-557	80	22	°	°	ADP
admet-557	80	23	c	c	NOUN
admet-557	80	24	,	,	PUNCT
admet-557	80	25	which	which	PRON
admet-557	80	26	were	be	AUX
admet-557	80	27	found	find	VERB
admet-557	80	28	to	to	PART
admet-557	80	29	be	be	AUX
admet-557	80	30	stable	stable	ADJ
admet-557	80	31	for	for	ADP
admet-557	80	32	one	one	NUM
admet-557	80	33	month	month	NOUN
admet-557	80	34	.	.	PUNCT
admet-557	81	1	the	the	DET
admet-557	81	2	primary	primary	ADJ
admet-557	81	3	stock	stock	NOUN
admet-557	81	4	solutions	solution	NOUN
admet-557	81	5	of	of	ADP
admet-557	81	6	enzalutamide	enzalutamide	NOUN
admet-557	81	7	,	,	PUNCT
admet-557	81	8	n	n	CCONJ
admet-557	81	9	-	-	PUNCT
admet-557	81	10	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	81	11	,	,	PUNCT
admet-557	81	12	darolutamide	darolutamide	NOUN
admet-557	81	13	and	and	CCONJ
admet-557	81	14	orm-15341	orm-15341	NOUN
admet-557	81	15	were	be	AUX
admet-557	81	16	successively	successively	ADV
admet-557	81	17	diluted	dilute	VERB
admet-557	81	18	in	in	ADP
admet-557	81	19	dmso	dmso	NOUN
admet-557	81	20	:	:	PUNCT
admet-557	81	21	methanol	methanol	NOUN
admet-557	81	22	(	(	PUNCT
admet-557	81	23	0.2:99.8	0.2:99.8	NUM
admet-557	81	24	,	,	PUNCT
admet-557	81	25	v	v	NOUN
admet-557	81	26	/	/	SYM
admet-557	81	27	v	v	NOUN
admet-557	81	28	)	)	PUNCT
admet-557	81	29	to	to	PART
admet-557	81	30	prepare	prepare	VERB
admet-557	81	31	secondary	secondary	ADJ
admet-557	81	32	stock	stock	NOUN
admet-557	81	33	and	and	CCONJ
admet-557	81	34	working	work	VERB
admet-557	81	35	stock	stock	NOUN
admet-557	81	36	solutions	solution	NOUN
admet-557	81	37	to	to	PART
admet-557	81	38	prepare	prepare	VERB
admet-557	81	39	cc	cc	PROPN
admet-557	81	40	and	and	CCONJ
admet-557	81	41	qc	qc	PROPN
admet-557	81	42	samples	sample	NOUN
admet-557	81	43	.	.	PUNCT
admet-557	82	1	working	work	VERB
admet-557	82	2	stock	stock	NOUN
admet-557	82	3	solutions	solution	NOUN
admet-557	82	4	were	be	AUX
admet-557	82	5	stored	store	VERB
admet-557	82	6	approximately	approximately	ADV
admet-557	82	7	at	at	ADP
admet-557	82	8	4	4	NUM
admet-557	82	9	°	°	ADP
admet-557	82	10	c	c	NOUN
admet-557	82	11	for	for	ADP
admet-557	82	12	30	30	NUM
admet-557	82	13	days	day	NOUN
admet-557	82	14	and	and	CCONJ
admet-557	82	15	found	find	VERB
admet-557	82	16	to	to	PART
admet-557	82	17	be	be	AUX
admet-557	82	18	stable	stable	ADJ
admet-557	82	19	.	.	PUNCT
admet-557	83	1	a	a	DET
admet-557	83	2	working	work	VERB
admet-557	83	3	stock	stock	NOUN
admet-557	83	4	of	of	ADP
admet-557	83	5	the	the	PRON
admet-557	83	6	is	be	AUX
admet-557	83	7	solution	solution	NOUN
admet-557	83	8	(	(	PUNCT
admet-557	83	9	25	25	NUM
admet-557	83	10	ng	ng	PROPN
admet-557	83	11	/	/	SYM
admet-557	83	12	ml	ml	PROPN
admet-557	83	13	)	)	PUNCT
admet-557	83	14	was	be	AUX
admet-557	83	15	prepared	prepare	VERB
admet-557	83	16	in	in	ADP
admet-557	83	17	methanol	methanol	NOUN
admet-557	83	18	.	.	PUNCT
admet-557	84	1	samples	sample	NOUN
admet-557	84	2	for	for	ADP
admet-557	84	3	the	the	DET
admet-557	84	4	determination	determination	NOUN
admet-557	84	5	of	of	ADP
admet-557	84	6	precision	precision	NOUN
admet-557	84	7	and	and	CCONJ
admet-557	84	8	accuracy	accuracy	NOUN
admet-557	84	9	were	be	AUX
admet-557	84	10	prepared	prepare	VERB
admet-557	84	11	by	by	ADP
admet-557	84	12	spiking	spike	VERB
admet-557	84	13	control	control	NOUN
admet-557	84	14	mice	mice	NOUN
admet-557	84	15	blood	blood	NOUN
admet-557	84	16	in	in	ADP
admet-557	84	17	bulk	bulk	NOUN
admet-557	84	18	with	with	ADP
admet-557	84	19	mixed	mixed	ADJ
admet-557	84	20	working	working	NOUN
admet-557	84	21	stock	stock	NOUN
admet-557	84	22	solution	solution	NOUN
admet-557	84	23	of	of	ADP
admet-557	84	24	enzalutamide	enzalutamide	NOUN
admet-557	84	25	,	,	PUNCT
admet-557	84	26	n	n	CCONJ
admet-557	84	27	-	-	PUNCT
admet-557	84	28	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	84	29	,	,	PUNCT
admet-557	84	30	darolutamide	darolutamide	NOUN
admet-557	84	31	and	and	CCONJ
admet-557	84	32	orm-15341	orm-15341	NOUN
admet-557	84	33	at	at	ADP
admet-557	84	34	appropriate	appropriate	ADJ
admet-557	84	35	concentrations	concentration	NOUN
admet-557	84	36	0.93	0.93	NUM
admet-557	84	37	ng	ng	PROPN
admet-557	84	38	/	/	SYM
admet-557	84	39	ml	ml	PROPN
admet-557	84	40	(	(	PUNCT
admet-557	84	41	lower	low	ADJ
admet-557	84	42	limit	limit	NOUN
admet-557	84	43	of	of	ADP
admet-557	84	44	quantitation	quantitation	NOUN
admet-557	84	45	quality	quality	NOUN
admet-557	84	46	control	control	NOUN
admet-557	84	47	,	,	PUNCT
admet-557	84	48	lloq	lloq	PROPN
admet-557	84	49	qc	qc	PROPN
admet-557	84	50	)	)	PUNCT
admet-557	84	51	,	,	PUNCT
admet-557	84	52	2.80	2.80	NUM
admet-557	84	53	ng	ng	PROPN
admet-557	84	54	/	/	SYM
admet-557	84	55	ml	ml	PROPN
admet-557	84	56	(	(	PUNCT
admet-557	84	57	low	low	ADJ
admet-557	84	58	quality	quality	NOUN
admet-557	84	59	control	control	NOUN
admet-557	84	60	,	,	PUNCT
admet-557	84	61	lqc	lqc	PROPN
admet-557	84	62	)	)	PUNCT
admet-557	84	63	,	,	PUNCT
admet-557	84	64	853	853	NUM
admet-557	84	65	ng	ng	PROPN
admet-557	84	66	/	/	SYM
admet-557	84	67	ml	ml	PROPN
admet-557	84	68	(	(	PUNCT
admet-557	84	69	medium	medium	ADJ
admet-557	84	70	quality	quality	NOUN
admet-557	84	71	control	control	NOUN
admet-557	84	72	,	,	PUNCT
admet-557	84	73	mqc	mqc	PROPN
admet-557	84	74	)	)	PUNCT
admet-557	84	75	and	and	CCONJ
admet-557	84	76	1493	1493	NUM
admet-557	84	77	ng	ng	PROPN
admet-557	84	78	/	/	SYM
admet-557	84	79	ml	ml	PROPN
admet-557	84	80	(	(	PUNCT
admet-557	84	81	high	high	ADJ
admet-557	84	82	quality	quality	NOUN
admet-557	84	83	control	control	NOUN
admet-557	84	84	,	,	PUNCT
admet-557	84	85	hqc	hqc	PROPN
admet-557	84	86	)	)	PUNCT
admet-557	84	87	.	.	PUNCT
admet-557	85	1	dbs	dbs	PROPN
admet-557	85	2	cards	card	NOUN
admet-557	85	3	were	be	AUX
admet-557	85	4	prepared	prepare	VERB
admet-557	85	5	(	(	PUNCT
admet-557	85	6	as	as	SCONJ
admet-557	85	7	mentioned	mention	VERB
admet-557	85	8	in	in	ADP
admet-557	85	9	blood	blood	NOUN
admet-557	85	10	spotting	spot	VERB
admet-557	85	11	section	section	NOUN
admet-557	85	12	)	)	PUNCT
admet-557	85	13	at	at	ADP
admet-557	85	14	each	each	DET
admet-557	85	15	qc	qc	PROPN
admet-557	85	16	level	level	NOUN
admet-557	85	17	and	and	CCONJ
admet-557	85	18	were	be	AUX
admet-557	85	19	stored	store	VERB
admet-557	85	20	at	at	ADP
admet-557	85	21	-80	-80	SYM
admet-557	85	22	±	±	NUM
admet-557	85	23	10	10	NUM
admet-557	85	24	°	°	ADP
admet-557	85	25	c	c	NOUN
admet-557	85	26	until	until	ADP
admet-557	85	27	analysis	analysis	NOUN
admet-557	85	28	.	.	PUNCT
admet-557	86	1	blood	blood	NOUN
admet-557	86	2	spotting	spot	VERB
admet-557	86	3	the	the	DET
admet-557	86	4	dbs	dbs	PROPN
admet-557	86	5	cards	card	NOUN
admet-557	86	6	were	be	AUX
admet-557	86	7	prepared	prepare	VERB
admet-557	86	8	from	from	ADP
admet-557	86	9	freshly	freshly	ADV
admet-557	86	10	drawn	draw	VERB
admet-557	86	11	whole	whole	ADJ
admet-557	86	12	blood	blood	NOUN
admet-557	86	13	,	,	PUNCT
admet-557	86	14	harvested	harvest	VERB
admet-557	86	15	on	on	ADP
admet-557	86	16	the	the	DET
admet-557	86	17	same	same	ADJ
admet-557	86	18	day	day	NOUN
admet-557	86	19	by	by	ADP
admet-557	86	20	spotting	spot	VERB
admet-557	86	21	25	25	NUM
admet-557	86	22	µl	µl	NOUN
admet-557	86	23	of	of	ADP
admet-557	86	24	the	the	DET
admet-557	86	25	respective	respective	ADJ
admet-557	86	26	spiked	spiked	ADJ
admet-557	86	27	cc	cc	PROPN
admet-557	86	28	/	/	SYM
admet-557	86	29	qc	qc	PROPN
admet-557	86	30	or	or	CCONJ
admet-557	86	31	whole	whole	ADJ
admet-557	86	32	blood	blood	NOUN
admet-557	86	33	from	from	ADP
admet-557	86	34	the	the	DET
admet-557	86	35	enzalutamide	enzalutamide	NOUN
admet-557	86	36	,	,	PUNCT
admet-557	86	37	n	n	CCONJ
admet-557	86	38	-	-	PUNCT
admet-557	86	39	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	86	40	,	,	PUNCT
admet-557	86	41	darolutamide	darolutamide	NOUN
admet-557	86	42	and	and	CCONJ
admet-557	86	43	orm-15341	orm-15341	NOUN
admet-557	86	44	treated	treat	VERB
admet-557	86	45	mouse	mouse	NOUN
admet-557	86	46	onto	onto	ADP
admet-557	86	47	sampling	sample	VERB
admet-557	86	48	paper	paper	NOUN
admet-557	86	49	using	use	VERB
admet-557	86	50	a	a	DET
admet-557	86	51	calibrated	calibrate	VERB
admet-557	86	52	pipette	pipette	NOUN
admet-557	86	53	.	.	PUNCT
admet-557	87	1	the	the	DET
admet-557	87	2	samples	sample	NOUN
admet-557	87	3	were	be	AUX
admet-557	87	4	left	leave	VERB
admet-557	87	5	to	to	PART
admet-557	87	6	dry	dry	VERB
admet-557	87	7	at	at	ADP
admet-557	87	8	room	room	NOUN
admet-557	87	9	temperature	temperature	NOUN
admet-557	87	10	least	least	ADV
admet-557	87	11	3	3	NUM
admet-557	87	12	h	h	NOUN
admet-557	87	13	before	before	ADP
admet-557	87	14	storing	store	VERB
admet-557	87	15	at	at	ADP
admet-557	87	16	controlled	control	VERB
admet-557	87	17	room	room	NOUN
admet-557	87	18	temperature	temperature	NOUN
admet-557	87	19	(	(	PUNCT
admet-557	87	20	24	24	NUM
admet-557	87	21	±	±	NUM
admet-557	87	22	1	1	NUM
admet-557	87	23	°	°	ADP
admet-557	87	24	c	c	NOUN
admet-557	87	25	)	)	PUNCT
admet-557	87	26	until	until	ADP
admet-557	87	27	analysis	analysis	NOUN
admet-557	87	28	.	.	PUNCT
admet-557	88	1	recovery	recovery	NOUN
admet-557	88	2	the	the	DET
admet-557	88	3	efficiency	efficiency	NOUN
admet-557	88	4	of	of	ADP
admet-557	88	5	enzalutamide	enzalutamide	NOUN
admet-557	88	6	,	,	PUNCT
admet-557	88	7	n	n	CCONJ
admet-557	88	8	-	-	PUNCT
admet-557	88	9	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	88	10	,	,	PUNCT
admet-557	88	11	darolutamide	darolutamide	NOUN
admet-557	88	12	,	,	PUNCT
admet-557	88	13	orm-15341	orm-15341	NOUN
admet-557	88	14	and	and	CCONJ
admet-557	88	15	the	the	PRON
admet-557	88	16	is	be	AUX
admet-557	88	17	extraction	extraction	NOUN
admet-557	88	18	from	from	ADP
admet-557	88	19	dbs	dbs	PROPN
admet-557	88	20	samples	sample	NOUN
admet-557	88	21	was	be	AUX
admet-557	88	22	determined	determine	VERB
admet-557	88	23	by	by	ADP
admet-557	88	24	comparing	compare	VERB
admet-557	88	25	the	the	DET
admet-557	88	26	responses	response	NOUN
admet-557	88	27	of	of	ADP
admet-557	88	28	the	the	DET
admet-557	88	29	analyte	analyte	NOUN
admet-557	88	30	extracted	extract	VERB
admet-557	88	31	from	from	ADP
admet-557	88	32	replicate	replicate	PROPN
admet-557	88	33	qc	qc	PROPN
admet-557	88	34	samples	sample	NOUN
admet-557	88	35	(	(	PUNCT
admet-557	88	36	n	n	NOUN
admet-557	88	37	=	=	SYM
admet-557	88	38	6	6	NUM
admet-557	88	39	)	)	PUNCT
admet-557	88	40	with	with	ADP
admet-557	88	41	the	the	DET
admet-557	88	42	response	response	NOUN
admet-557	88	43	of	of	ADP
admet-557	88	44	analyte	analyte	NOUN
admet-557	88	45	from	from	ADP
admet-557	88	46	neat	neat	ADJ
admet-557	88	47	standards	standard	NOUN
admet-557	88	48	at	at	ADP
admet-557	88	49	equivalent	equivalent	ADJ
admet-557	88	50	concentrations	concentration	NOUN
admet-557	88	51	by	by	ADP
admet-557	88	52	liquid	liquid	ADJ
admet-557	88	53	extraction	extraction	NOUN
admet-557	88	54	process	process	NOUN
admet-557	88	55	.	.	PUNCT
admet-557	89	1	recovery	recovery	NOUN
admet-557	89	2	of	of	ADP
admet-557	89	3	enzalutamide	enzalutamide	NOUN
admet-557	89	4	,	,	PUNCT
admet-557	89	5	n	n	CCONJ
admet-557	89	6	-	-	PUNCT
admet-557	89	7	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	89	8	,	,	PUNCT
admet-557	89	9	darolutamide	darolutamide	NOUN
admet-557	89	10	and	and	CCONJ
admet-557	89	11	r.	r.	PROPN
admet-557	89	12	mullangi	mullangi	PROPN
admet-557	89	13	et	et	PROPN
admet-557	89	14	al	al	PROPN
admet-557	89	15	.	.	PROPN
admet-557	89	16	admet	admet	PROPN
admet-557	89	17	&	&	CCONJ
admet-557	89	18	dmpk	dmpk	PROPN
admet-557	89	19	6(3	6(3	PROPN
admet-557	89	20	)	)	PUNCT
admet-557	89	21	(	(	PUNCT
admet-557	89	22	2018	2018	NUM
admet-557	89	23	)	)	PUNCT
admet-557	89	24	242	242	NUM
admet-557	89	25	-	-	SYM
admet-557	89	26	257	257	NUM
admet-557	89	27	246	246	NUM
admet-557	89	28	orm-15341	orm-15341	NOUN
admet-557	89	29	was	be	AUX
admet-557	89	30	determined	determine	VERB
admet-557	89	31	at	at	ADP
admet-557	89	32	lqc	lqc	PROPN
admet-557	89	33	(	(	PUNCT
admet-557	89	34	2.80	2.80	NUM
admet-557	89	35	ng	ng	PROPN
admet-557	89	36	/	/	SYM
admet-557	89	37	ml	ml	PROPN
admet-557	89	38	)	)	PUNCT
admet-557	89	39	and	and	CCONJ
admet-557	89	40	hqc	hqc	INTJ
admet-557	89	41	(	(	PUNCT
admet-557	89	42	1493	1493	NUM
admet-557	89	43	ng	ng	PROPN
admet-557	89	44	/	/	SYM
admet-557	89	45	ml	ml	NOUN
admet-557	89	46	)	)	PUNCT
admet-557	89	47	concentrations	concentration	NOUN
admet-557	89	48	.	.	PUNCT
admet-557	90	1	recovery	recovery	NOUN
admet-557	90	2	of	of	ADP
admet-557	90	3	the	the	PRON
admet-557	90	4	is	be	AUX
admet-557	90	5	was	be	AUX
admet-557	90	6	determined	determine	VERB
admet-557	90	7	at	at	ADP
admet-557	90	8	a	a	DET
admet-557	90	9	single	single	ADJ
admet-557	90	10	concentration	concentration	NOUN
admet-557	90	11	of	of	ADP
admet-557	90	12	25	25	NUM
admet-557	90	13	ng	ng	PROPN
admet-557	90	14	/	/	SYM
admet-557	90	15	ml	ml	NOUN
admet-557	90	16	.	.	PUNCT
admet-557	91	1	samples	sample	NOUN
admet-557	91	2	were	be	AUX
admet-557	91	3	prepared	prepare	VERB
admet-557	91	4	by	by	ADP
admet-557	91	5	punching	punch	VERB
admet-557	91	6	a	a	DET
admet-557	91	7	3	3	NUM
admet-557	91	8	mm	mm	NOUN
admet-557	91	9	diameter	diameter	NOUN
admet-557	91	10	disk	disk	NOUN
admet-557	91	11	from	from	ADP
admet-557	91	12	the	the	DET
admet-557	91	13	centre	centre	NOUN
admet-557	91	14	of	of	ADP
admet-557	91	15	the	the	DET
admet-557	91	16	dbs	dbs	NOUN
admet-557	91	17	using	use	VERB
admet-557	91	18	a	a	DET
admet-557	91	19	hole	hole	NOUN
admet-557	91	20	puncher	puncher	NOUN
admet-557	91	21	(	(	PUNCT
admet-557	91	22	harri	harri	NOUN
admet-557	91	23	-	-	PUNCT
admet-557	91	24	micro	micro	NOUN
admet-557	91	25	-	-	NOUN
admet-557	91	26	punch	punch	ADJ
admet-557	91	27			PROPN
admet-557	91	28	,	,	PUNCT
admet-557	91	29	3	3	NUM
admet-557	91	30	mm	mm	NOUN
admet-557	91	31	circle	circle	NOUN
admet-557	91	32	)	)	PUNCT
admet-557	91	33	into	into	ADP
admet-557	91	34	a	a	DET
admet-557	91	35	2.0	2.0	NUM
admet-557	91	36	ml	ml	NOUN
admet-557	91	37	microcentrifuge	microcentrifuge	ADJ
admet-557	91	38	tube	tube	NOUN
admet-557	91	39	using	use	VERB
admet-557	91	40	the	the	DET
admet-557	91	41	200	200	NUM
admet-557	91	42	µl	µl	NOUN
admet-557	91	43	of	of	ADP
admet-557	91	44	extraction	extraction	NOUN
admet-557	91	45	solvents	solvent	NOUN
admet-557	91	46	viz	viz	PROPN
admet-557	91	47	.	.	PROPN
admet-557	91	48	,	,	PUNCT
admet-557	91	49	tbme	tbme	PROPN
admet-557	91	50	,	,	PUNCT
admet-557	91	51	ethyl	ethyl	PROPN
admet-557	91	52	acetate	acetate	NOUN
admet-557	91	53	,	,	PUNCT
admet-557	91	54	methanol	methanol	NOUN
admet-557	91	55	,	,	PUNCT
admet-557	91	56	acetonitrile	acetonitrile	NOUN
admet-557	91	57	,	,	PUNCT
admet-557	91	58	methanol	methanol	NOUN
admet-557	91	59	/	/	SYM
admet-557	91	60	acetonitrile	acetonitrile	NOUN
admet-557	91	61	:	:	PUNCT
admet-557	91	62	water	water	NOUN
admet-557	91	63	(	(	PUNCT
admet-557	91	64	in	in	ADP
admet-557	91	65	different	different	ADJ
admet-557	91	66	ratios	ratio	NOUN
admet-557	91	67	)	)	PUNCT
admet-557	91	68	.	.	PUNCT
admet-557	92	1	sample	sample	NOUN
admet-557	92	2	preparation	preparation	NOUN
admet-557	92	3	to	to	ADP
admet-557	92	4	each	each	DET
admet-557	92	5	dbs	dbs	NOUN
admet-557	92	6	card	card	NOUN
admet-557	92	7	(	(	PUNCT
admet-557	92	8	3	3	NUM
admet-557	92	9	mm	mm	NOUN
admet-557	92	10	)	)	PUNCT
admet-557	92	11	in	in	ADP
admet-557	92	12	a	a	DET
admet-557	92	13	glass	glass	NOUN
admet-557	92	14	tube	tube	NOUN
admet-557	92	15	,	,	PUNCT
admet-557	92	16	200	200	NUM
admet-557	92	17	µl	µl	NOUN
admet-557	92	18	of	of	ADP
admet-557	92	19	water	water	NOUN
admet-557	92	20	was	be	AUX
admet-557	92	21	added	add	VERB
admet-557	92	22	vortex	vortex	NOUN
admet-557	92	23	mixed	mix	VERB
admet-557	92	24	for	for	ADP
admet-557	92	25	10	10	NUM
admet-557	92	26	min	min	NOUN
admet-557	92	27	and	and	CCONJ
admet-557	92	28	sonicated	sonicate	VERB
admet-557	92	29	for	for	ADP
admet-557	92	30	10	10	NUM
admet-557	92	31	min	min	NOUN
admet-557	92	32	at	at	ADP
admet-557	92	33	room	room	NOUN
admet-557	92	34	temperature	temperature	NOUN
admet-557	92	35	.	.	PUNCT
admet-557	93	1	post	post	NOUN
admet-557	93	2	sonication	sonication	NOUN
admet-557	93	3	200	200	NUM
admet-557	93	4	µl	µl	NOUN
admet-557	93	5	of	of	ADP
admet-557	93	6	acetonitrile	acetonitrile	NOUN
admet-557	93	7	enriched	enrich	VERB
admet-557	93	8	with	with	ADP
admet-557	93	9	the	the	DET
admet-557	93	10	is	is	NOUN
admet-557	93	11	(	(	PUNCT
admet-557	93	12	25	25	NUM
admet-557	93	13	ng	ng	PROPN
admet-557	93	14	/	/	SYM
admet-557	93	15	ml	ml	PROPN
admet-557	93	16	)	)	PUNCT
admet-557	93	17	was	be	AUX
admet-557	93	18	added	add	VERB
admet-557	93	19	vortex	vortex	NOUN
admet-557	93	20	mixed	mix	VERB
admet-557	93	21	for	for	ADP
admet-557	93	22	10	10	NUM
admet-557	93	23	min	min	NOUN
admet-557	93	24	followed	follow	VERB
admet-557	93	25	by	by	ADP
admet-557	93	26	centrifugation	centrifugation	NOUN
admet-557	93	27	10	10	NUM
admet-557	93	28	min	min	NOUN
admet-557	93	29	.	.	PROPN
admet-557	93	30	clear	clear	ADJ
admet-557	93	31	supernatant	supernatant	NOUN
admet-557	93	32	(	(	PUNCT
admet-557	93	33	200	200	NUM
admet-557	93	34	µl	µl	NOUN
admet-557	93	35	)	)	PUNCT
admet-557	93	36	was	be	AUX
admet-557	93	37	separated	separate	VERB
admet-557	93	38	and	and	CCONJ
admet-557	93	39	transferred	transfer	VERB
admet-557	93	40	into	into	ADP
admet-557	93	41	a	a	DET
admet-557	93	42	hplc	hplc	NOUN
admet-557	93	43	vial	vial	NOUN
admet-557	93	44	for	for	ADP
admet-557	93	45	injection	injection	NOUN
admet-557	93	46	and	and	CCONJ
admet-557	93	47	5.0	5.0	NUM
admet-557	93	48	µl	µl	NOUN
admet-557	93	49	was	be	AUX
admet-557	93	50	injected	inject	VERB
admet-557	93	51	onto	onto	ADP
admet-557	93	52	lcms	lcms	PROPN
admet-557	93	53	/	/	SYM
admet-557	93	54	ms	ms	NOUN
admet-557	93	55	system	system	NOUN
admet-557	93	56	.	.	PUNCT
admet-557	94	1	method	method	PROPN
admet-557	94	2	validation	validation	NOUN
admet-557	94	3	the	the	DET
admet-557	94	4	validation	validation	NOUN
admet-557	94	5	experiments	experiment	NOUN
admet-557	94	6	were	be	AUX
admet-557	94	7	performed	perform	VERB
admet-557	94	8	in	in	ADP
admet-557	94	9	accordance	accordance	NOUN
admet-557	94	10	with	with	ADP
admet-557	94	11	the	the	DET
admet-557	94	12	us	us	PROPN
admet-557	94	13	food	food	NOUN
admet-557	94	14	and	and	CCONJ
admet-557	94	15	drug	drug	PROPN
admet-557	94	16	administration	administration	PROPN
admet-557	94	17	guideline	guideline	NOUN
admet-557	95	1	[	[	X
admet-557	95	2	27	27	NUM
admet-557	95	3	]	]	PUNCT
admet-557	95	4	.	.	PUNCT
admet-557	96	1	selectivity	selectivity	ADJ
admet-557	96	2	selectivity	selectivity	NOUN
admet-557	96	3	of	of	ADP
admet-557	96	4	the	the	DET
admet-557	96	5	method	method	NOUN
admet-557	96	6	was	be	AUX
admet-557	96	7	determined	determine	VERB
admet-557	96	8	by	by	ADP
admet-557	96	9	determining	determine	VERB
admet-557	96	10	the	the	DET
admet-557	96	11	presence	presence	NOUN
admet-557	96	12	of	of	ADP
admet-557	96	13	interfering	interfere	VERB
admet-557	96	14	peaks	peak	NOUN
admet-557	96	15	from	from	ADP
admet-557	96	16	six	six	NUM
admet-557	96	17	individual	individual	ADJ
admet-557	96	18	drug	drug	NOUN
admet-557	96	19	-	-	PUNCT
admet-557	96	20	free	free	ADJ
admet-557	96	21	mice	mouse	NOUN
admet-557	96	22	dbs	dbs	NOUN
admet-557	96	23	samples	sample	NOUN
admet-557	96	24	at	at	ADP
admet-557	96	25	the	the	DET
admet-557	96	26	retention	retention	NOUN
admet-557	96	27	times	time	NOUN
admet-557	96	28	of	of	ADP
admet-557	96	29	enzalutamide	enzalutamide	NOUN
admet-557	96	30	,	,	PUNCT
admet-557	96	31	n	n	CCONJ
admet-557	96	32	-	-	PUNCT
admet-557	96	33	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	96	34	,	,	PUNCT
admet-557	96	35	darolutamide	darolutamide	NOUN
admet-557	96	36	,	,	PUNCT
admet-557	96	37	orm-15341	orm-15341	NOUN
admet-557	96	38	and	and	CCONJ
admet-557	96	39	the	the	PRON
admet-557	96	40	is	be	AUX
admet-557	96	41	.	.	PUNCT
admet-557	97	1	limit	limit	NOUN
admet-557	97	2	of	of	ADP
admet-557	97	3	quantification	quantification	NOUN
admet-557	97	4	and	and	CCONJ
admet-557	97	5	carry	carry	VERB
admet-557	97	6	over	over	ADP
admet-557	97	7	the	the	DET
admet-557	97	8	lloq	lloq	NOUN
admet-557	97	9	was	be	AUX
admet-557	97	10	determined	determine	VERB
admet-557	97	11	as	as	ADP
admet-557	97	12	the	the	DET
admet-557	97	13	concentration	concentration	NOUN
admet-557	97	14	that	that	PRON
admet-557	97	15	has	have	VERB
admet-557	97	16	a	a	DET
admet-557	97	17	precision	precision	NOUN
admet-557	97	18	of	of	ADP
admet-557	97	19	<	<	X
admet-557	97	20	20	20	NUM
admet-557	97	21	%	%	NOUN
admet-557	97	22	of	of	ADP
admet-557	97	23	the	the	DET
admet-557	97	24	relative	relative	ADJ
admet-557	97	25	standard	standard	ADJ
admet-557	97	26	deviation	deviation	NOUN
admet-557	97	27	and	and	CCONJ
admet-557	97	28	accuracy	accuracy	NOUN
admet-557	97	29	between	between	ADP
admet-557	97	30	80	80	NUM
admet-557	97	31	-	-	SYM
admet-557	97	32	120	120	NUM
admet-557	97	33	%	%	NOUN
admet-557	97	34	of	of	ADP
admet-557	97	35	the	the	DET
admet-557	97	36	theoretical	theoretical	ADJ
admet-557	97	37	value	value	NOUN
admet-557	97	38	.	.	PUNCT
admet-557	98	1	the	the	DET
admet-557	98	2	auto	auto	NOUN
admet-557	98	3	-	-	PUNCT
admet-557	98	4	injector	injector	NOUN
admet-557	98	5	carryover	carryover	NOUN
admet-557	98	6	was	be	AUX
admet-557	98	7	determined	determine	VERB
admet-557	98	8	by	by	ADP
admet-557	98	9	injecting	inject	VERB
admet-557	98	10	the	the	DET
admet-557	98	11	highest	high	ADJ
admet-557	98	12	calibration	calibration	NOUN
admet-557	98	13	standard	standard	NOUN
admet-557	98	14	,	,	PUNCT
admet-557	98	15	followed	follow	VERB
admet-557	98	16	by	by	ADP
admet-557	98	17	injection	injection	NOUN
admet-557	98	18	of	of	ADP
admet-557	98	19	blank	blank	ADJ
admet-557	98	20	samples	sample	NOUN
admet-557	98	21	.	.	PUNCT
admet-557	99	1	the	the	DET
admet-557	99	2	response	response	NOUN
admet-557	99	3	of	of	ADP
admet-557	99	4	the	the	DET
admet-557	99	5	blanks	blank	NOUN
admet-557	99	6	was	be	AUX
admet-557	99	7	then	then	ADV
admet-557	99	8	compared	compare	VERB
admet-557	99	9	to	to	ADP
admet-557	99	10	that	that	PRON
admet-557	99	11	of	of	ADP
admet-557	99	12	the	the	DET
admet-557	99	13	lloq	lloq	NOUN
admet-557	99	14	.	.	PUNCT
admet-557	100	1	calibration	calibration	NOUN
admet-557	100	2	curve	curve	NOUN
admet-557	100	3	calibration	calibration	NOUN
admet-557	100	4	samples	sample	NOUN
admet-557	100	5	(	(	PUNCT
admet-557	100	6	for	for	ADP
admet-557	100	7	all	all	DET
admet-557	100	8	the	the	DET
admet-557	100	9	analytes	analyte	NOUN
admet-557	100	10	)	)	PUNCT
admet-557	100	11	were	be	AUX
admet-557	100	12	prepared	prepare	VERB
admet-557	100	13	on	on	ADP
admet-557	100	14	each	each	DET
admet-557	100	15	validation	validation	NOUN
admet-557	100	16	day	day	NOUN
admet-557	100	17	.	.	PUNCT
admet-557	101	1	peak	peak	NOUN
admet-557	101	2	area	area	NOUN
admet-557	101	3	ratios	ratio	NOUN
admet-557	101	4	of	of	ADP
admet-557	101	5	each	each	DET
admet-557	101	6	analyte	analyte	NOUN
admet-557	101	7	to	to	ADP
admet-557	101	8	that	that	PRON
admet-557	101	9	of	of	ADP
admet-557	101	10	is	be	AUX
admet-557	101	11	were	be	AUX
admet-557	101	12	used	use	VERB
admet-557	101	13	for	for	ADP
admet-557	101	14	all	all	DET
admet-557	101	15	calculations	calculation	NOUN
admet-557	101	16	.	.	PUNCT
admet-557	102	1	a	a	DET
admet-557	102	2	least	least	ADJ
admet-557	102	3	squares	square	NOUN
admet-557	102	4	linear	linear	ADJ
admet-557	102	5	regression	regression	NOUN
admet-557	102	6	(	(	PUNCT
admet-557	102	7	1	1	NUM
admet-557	102	8	/	/	SYM
admet-557	102	9	x2	x2	ADJ
admet-557	102	10	weighting	weighting	NOUN
admet-557	102	11	factor	factor	NOUN
admet-557	102	12	)	)	PUNCT
admet-557	102	13	of	of	ADP
admet-557	102	14	eight	eight	NUM
admet-557	102	15	non	non	ADJ
admet-557	102	16	-	-	ADJ
admet-557	102	17	zero	zero	NUM
admet-557	102	18	samples	sample	NOUN
admet-557	102	19	was	be	AUX
admet-557	102	20	used	use	VERB
admet-557	102	21	to	to	PART
admet-557	102	22	define	define	VERB
admet-557	102	23	the	the	DET
admet-557	102	24	calibration	calibration	NOUN
admet-557	102	25	curve	curve	NOUN
admet-557	102	26	.	.	PUNCT
admet-557	103	1	precision	precision	NOUN
admet-557	103	2	and	and	CCONJ
admet-557	103	3	accuracy	accuracy	NOUN
admet-557	103	4	the	the	DET
admet-557	103	5	precision	precision	NOUN
admet-557	103	6	and	and	CCONJ
admet-557	103	7	accuracy	accuracy	NOUN
admet-557	103	8	of	of	ADP
admet-557	103	9	the	the	DET
admet-557	103	10	method	method	NOUN
admet-557	103	11	were	be	AUX
admet-557	103	12	evaluated	evaluate	VERB
admet-557	103	13	by	by	ADP
admet-557	103	14	measuring	measure	VERB
admet-557	103	15	the	the	DET
admet-557	103	16	four	four	NUM
admet-557	103	17	qc	qc	NOUN
admet-557	103	18	samples	sample	NOUN
admet-557	103	19	(	(	PUNCT
admet-557	103	20	lloq	lloq	PROPN
admet-557	103	21	qc	qc	PROPN
admet-557	103	22	,	,	PUNCT
admet-557	103	23	lqc	lqc	PROPN
admet-557	103	24	,	,	PUNCT
admet-557	103	25	mqc	mqc	PROPN
admet-557	103	26	and	and	CCONJ
admet-557	103	27	hqc	hqc	PROPN
admet-557	103	28	)	)	PUNCT
admet-557	103	29	,	,	PUNCT
admet-557	103	30	which	which	PRON
admet-557	103	31	were	be	AUX
admet-557	103	32	prepared	prepare	VERB
admet-557	103	33	on	on	ADP
admet-557	103	34	each	each	DET
admet-557	103	35	validation	validation	NOUN
admet-557	103	36	day	day	NOUN
admet-557	103	37	(	(	PUNCT
admet-557	103	38	n	n	NOUN
admet-557	103	39	=	=	SYM
admet-557	103	40	6	6	NUM
admet-557	103	41	each	each	PRON
admet-557	103	42	)	)	PUNCT
admet-557	103	43	.	.	PUNCT
admet-557	104	1	inter	inter	ADJ
admet-557	104	2	-	-	ADJ
admet-557	104	3	day	day	ADJ
admet-557	104	4	precision	precision	NOUN
admet-557	104	5	was	be	AUX
admet-557	104	6	assessed	assess	VERB
admet-557	104	7	on	on	ADP
admet-557	104	8	three	three	NUM
admet-557	104	9	separate	separate	ADJ
admet-557	104	10	days	day	NOUN
admet-557	104	11	.	.	PUNCT
admet-557	105	1	interand	interand	VERB
admet-557	105	2	intra	intra	ADJ
admet-557	105	3	-	-	ADJ
admet-557	105	4	day	day	NOUN
admet-557	105	5	precisions	precision	NOUN
admet-557	105	6	were	be	AUX
admet-557	105	7	determined	determine	VERB
admet-557	105	8	by	by	ADP
admet-557	105	9	calculating	calculate	VERB
admet-557	105	10	percent	percent	NOUN
admet-557	105	11	relative	relative	ADJ
admet-557	105	12	standard	standard	ADJ
admet-557	105	13	deviation	deviation	NOUN
admet-557	105	14	(	(	PUNCT
admet-557	105	15	%	%	INTJ
admet-557	105	16	rsd	rsd	NOUN
admet-557	105	17	)	)	PUNCT
admet-557	105	18	that	that	PRON
admet-557	105	19	should	should	AUX
admet-557	105	20	be	be	AUX
admet-557	105	21	<	<	X
admet-557	105	22	15	15	NUM
admet-557	105	23	%	%	NOUN
admet-557	105	24	for	for	ADP
admet-557	105	25	all	all	DET
admet-557	105	26	the	the	DET
admet-557	105	27	qc	qc	PROPN
admet-557	105	28	levels	level	NOUN
admet-557	105	29	except	except	SCONJ
admet-557	105	30	for	for	ADP
admet-557	105	31	lloq	lloq	PROPN
admet-557	105	32	qc	qc	PROPN
admet-557	105	33	where	where	SCONJ
admet-557	105	34	it	it	PRON
admet-557	105	35	should	should	AUX
admet-557	105	36	be	be	AUX
admet-557	105	37	<	<	X
admet-557	105	38	20	20	NUM
admet-557	105	39	%	%	NOUN
admet-557	105	40	.	.	PUNCT
admet-557	106	1	the	the	DET
admet-557	106	2	interand	interand	NOUN
admet-557	106	3	intra	intra	ADJ
admet-557	106	4	-	-	ADJ
admet-557	106	5	day	day	NOUN
admet-557	106	6	accuracy	accuracy	NOUN
admet-557	106	7	expressed	express	VERB
admet-557	106	8	as	as	ADP
admet-557	106	9	percent	percent	NOUN
admet-557	106	10	relative	relative	ADJ
admet-557	106	11	error	error	NOUN
admet-557	106	12	(	(	PUNCT
admet-557	106	13	%	%	INTJ
admet-557	106	14	re	re	VERB
admet-557	106	15	)	)	PUNCT
admet-557	106	16	was	be	AUX
admet-557	106	17	calculated	calculate	VERB
admet-557	106	18	by	by	ADP
admet-557	106	19	comparing	compare	VERB
admet-557	106	20	the	the	DET
admet-557	106	21	measured	measured	ADJ
admet-557	106	22	concentration	concentration	NOUN
admet-557	106	23	with	with	ADP
admet-557	106	24	the	the	DET
admet-557	106	25	nominal	nominal	ADJ
admet-557	106	26	value	value	NOUN
admet-557	106	27	and	and	CCONJ
admet-557	106	28	deviation	deviation	NOUN
admet-557	106	29	was	be	AUX
admet-557	106	30	limited	limit	VERB
admet-557	106	31	within	within	ADP
admet-557	106	32	±15	±15	NOUN
admet-557	106	33	%	%	NOUN
admet-557	106	34	except	except	SCONJ
admet-557	106	35	for	for	ADP
admet-557	106	36	lloq	lloq	PROPN
admet-557	106	37	qc	qc	PROPN
admet-557	106	38	where	where	SCONJ
admet-557	106	39	it	it	PRON
admet-557	106	40	should	should	AUX
admet-557	106	41	be	be	AUX
admet-557	106	42	<	<	X
admet-557	106	43	20	20	NUM
admet-557	106	44	%	%	NOUN
admet-557	106	45	.	.	PUNCT
admet-557	107	1	matrix	matrix	NOUN
admet-557	107	2	effect	effect	NOUN
admet-557	107	3	matrix	matrix	NOUN
admet-557	107	4	effect	effect	NOUN
admet-557	107	5	for	for	ADP
admet-557	107	6	enzalutamide	enzalutamide	NOUN
admet-557	107	7	,	,	PUNCT
admet-557	107	8	n	n	CCONJ
admet-557	107	9	-	-	PUNCT
admet-557	107	10	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	107	11	,	,	PUNCT
admet-557	107	12	darolutamide	darolutamide	NOUN
admet-557	107	13	and	and	CCONJ
admet-557	107	14	orm-15341	orm-15341	NOUN
admet-557	107	15	was	be	AUX
admet-557	107	16	assessed	assess	VERB
admet-557	107	17	by	by	ADP
admet-557	107	18	comparing	compare	VERB
admet-557	107	19	each	each	DET
admet-557	107	20	analyte	analyte	NOUN
admet-557	107	21	mean	mean	VERB
admet-557	107	22	peak	peak	NOUN
admet-557	107	23	areas	area	NOUN
admet-557	107	24	at	at	ADP
admet-557	107	25	lqc	lqc	NOUN
admet-557	107	26	and	and	CCONJ
admet-557	107	27	hqc	hqc	INTJ
admet-557	107	28	concentration	concentration	NOUN
admet-557	107	29	after	after	ADP
admet-557	107	30	with	with	ADP
admet-557	107	31	the	the	DET
admet-557	107	32	mean	mean	ADJ
admet-557	107	33	peak	peak	NOUN
admet-557	107	34	areas	area	NOUN
admet-557	107	35	for	for	ADP
admet-557	107	36	post	post	NOUN
admet-557	107	37	extracted	extract	VERB
admet-557	107	38	dbs	dbs	NOUN
admet-557	107	39	samples	sample	NOUN
admet-557	107	40	spiked	spike	VERB
admet-557	107	41	with	with	ADP
admet-557	107	42	analyte	analyte	NOUN
admet-557	107	43	at	at	ADP
admet-557	107	44	equivalent	equivalent	ADJ
admet-557	107	45	concentrations	concentration	NOUN
admet-557	107	46	.	.	PUNCT
admet-557	108	1	matrix	matrix	NOUN
admet-557	108	2	effect	effect	NOUN
admet-557	108	3	for	for	ADP
admet-557	108	4	the	the	PRON
admet-557	108	5	is	be	AUX
admet-557	108	6	admet	admet	PROPN
admet-557	108	7	&	&	CCONJ
admet-557	108	8	dmpk	dmpk	PROPN
admet-557	108	9	6(3	6(3	PROPN
admet-557	108	10	)	)	PUNCT
admet-557	108	11	(	(	PUNCT
admet-557	108	12	2018	2018	NUM
admet-557	108	13	)	)	PUNCT
admet-557	108	14	242	242	NUM
admet-557	108	15	-	-	SYM
admet-557	108	16	257	257	NUM
admet-557	108	17	lc	lc	PROPN
admet-557	108	18	-	-	PUNCT
admet-557	108	19	ms	ms	PROPN
admet-557	108	20	/	/	SYM
admet-557	108	21	ms	ms	NOUN
admet-557	108	22	determination	determination	NOUN
admet-557	108	23	of	of	ADP
admet-557	108	24	enzalutamide	enzalutamide	ADV
admet-557	108	25	/	/	SYM
admet-557	108	26	darolutamide	darolutamide	NOUN
admet-557	108	27	with	with	ADP
admet-557	108	28	metabolites	metabolite	NOUN
admet-557	108	29	on	on	ADP
admet-557	108	30	dbs	dbs	PROPN
admet-557	108	31	doi	doi	PROPN
admet-557	108	32	:	:	PUNCT
admet-557	108	33	10.5599	10.5599	NUM
admet-557	108	34	/	/	SYM
admet-557	108	35	admet.557	admet.557	PROPN
admet-557	108	36	247	247	NUM
admet-557	108	37	was	be	AUX
admet-557	108	38	assessed	assess	VERB
admet-557	108	39	at	at	ADP
admet-557	108	40	single	single	ADJ
admet-557	108	41	concentration	concentration	NOUN
admet-557	108	42	(	(	PUNCT
admet-557	108	43	25	25	NUM
admet-557	108	44	ng	ng	PROPN
admet-557	108	45	/	/	SYM
admet-557	108	46	ml	ml	NOUN
admet-557	108	47	)	)	PUNCT
admet-557	108	48	.	.	PUNCT
admet-557	109	1	stability	stability	NOUN
admet-557	109	2	the	the	DET
admet-557	109	3	stability	stability	NOUN
admet-557	109	4	of	of	ADP
admet-557	109	5	enzalutamide	enzalutamide	NOUN
admet-557	109	6	,	,	PUNCT
admet-557	109	7	n	n	CCONJ
admet-557	109	8	-	-	PUNCT
admet-557	109	9	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	109	10	,	,	PUNCT
admet-557	109	11	darolutamide	darolutamide	NOUN
admet-557	109	12	and	and	CCONJ
admet-557	109	13	orm-15341	orm-15341	NOUN
admet-557	109	14	was	be	AUX
admet-557	109	15	assessed	assess	VERB
admet-557	109	16	at	at	ADP
admet-557	109	17	lqc	lqc	NOUN
admet-557	109	18	and	and	CCONJ
admet-557	109	19	hqc	hqc	PROPN
admet-557	109	20	levels	level	NOUN
admet-557	109	21	in	in	ADP
admet-557	109	22	six	six	NUM
admet-557	109	23	replicates	replicate	NOUN
admet-557	109	24	under	under	ADP
admet-557	109	25	all	all	DET
admet-557	109	26	storage	storage	NOUN
admet-557	109	27	conditions	condition	NOUN
admet-557	109	28	.	.	PUNCT
admet-557	110	1	freeze	freeze	NOUN
admet-557	110	2	-	-	PUNCT
admet-557	110	3	thaw	thaw	NOUN
admet-557	110	4	stability	stability	NOUN
admet-557	110	5	was	be	AUX
admet-557	110	6	performed	perform	VERB
admet-557	110	7	following	follow	VERB
admet-557	110	8	three	three	NUM
admet-557	110	9	freeze	freeze	ADJ
admet-557	110	10	-	-	PUNCT
admet-557	110	11	thaw	thaw	NOUN
admet-557	110	12	cycles	cycle	NOUN
admet-557	110	13	was	be	AUX
admet-557	110	14	evaluated	evaluate	VERB
admet-557	110	15	(	(	PUNCT
admet-557	110	16	dbs	dbs	ADJ
admet-557	110	17	cards	card	NOUN
admet-557	110	18	were	be	AUX
admet-557	110	19	stored	store	VERB
admet-557	110	20	in	in	ADP
admet-557	110	21	-80	-80	PUNCT
admet-557	110	22	±	±	NUM
admet-557	110	23	10	10	NUM
admet-557	110	24	°	°	ADP
admet-557	110	25	c	c	NOUN
admet-557	110	26	between	between	ADP
admet-557	110	27	freeze	freeze	VERB
admet-557	110	28	/	/	SYM
admet-557	110	29	thaw	thaw	NOUN
admet-557	110	30	cycles	cycle	NOUN
admet-557	110	31	)	)	PUNCT
admet-557	110	32	.	.	PUNCT
admet-557	111	1	short	short	ADJ
admet-557	111	2	-	-	PUNCT
admet-557	111	3	term	term	NOUN
admet-557	111	4	temperature	temperature	NOUN
admet-557	111	5	stability	stability	NOUN
admet-557	111	6	was	be	AUX
admet-557	111	7	assessed	assess	VERB
admet-557	111	8	by	by	ADP
admet-557	111	9	analyzing	analyze	VERB
admet-557	111	10	samples	sample	NOUN
admet-557	111	11	that	that	PRON
admet-557	111	12	had	have	AUX
admet-557	111	13	been	be	AUX
admet-557	111	14	kept	keep	VERB
admet-557	111	15	at	at	ADP
admet-557	111	16	ambient	ambient	ADJ
admet-557	111	17	temperature	temperature	NOUN
admet-557	111	18	(	(	PUNCT
admet-557	111	19	25	25	NUM
admet-557	111	20	±	±	NUM
admet-557	111	21	1	1	NUM
admet-557	111	22	°	°	ADP
admet-557	111	23	c	c	NOUN
admet-557	111	24	)	)	PUNCT
admet-557	111	25	for	for	ADP
admet-557	111	26	7	7	NUM
admet-557	111	27	days	day	NOUN
admet-557	111	28	.	.	PUNCT
admet-557	112	1	long	long	ADJ
admet-557	112	2	-	-	PUNCT
admet-557	112	3	term	term	NOUN
admet-557	112	4	stability	stability	NOUN
admet-557	112	5	was	be	AUX
admet-557	112	6	performed	perform	VERB
admet-557	112	7	by	by	ADP
admet-557	112	8	analyzing	analyze	VERB
admet-557	112	9	samples	sample	NOUN
admet-557	112	10	that	that	PRON
admet-557	112	11	had	have	AUX
admet-557	112	12	been	be	AUX
admet-557	112	13	stored	store	VERB
admet-557	112	14	at	at	ADP
admet-557	112	15	-80	-80	PUNCT
admet-557	112	16	±	±	NUM
admet-557	112	17	10	10	NUM
admet-557	112	18	°	°	ADP
admet-557	112	19	c	c	NOUN
admet-557	112	20	for	for	ADP
admet-557	112	21	30	30	NUM
admet-557	112	22	days	day	NOUN
admet-557	112	23	.	.	PUNCT
admet-557	113	1	the	the	DET
admet-557	113	2	stability	stability	NOUN
admet-557	113	3	of	of	ADP
admet-557	113	4	enzalutamide	enzalutamide	NOUN
admet-557	113	5	,	,	PUNCT
admet-557	113	6	n	n	CCONJ
admet-557	113	7	-	-	PUNCT
admet-557	113	8	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	113	9	,	,	PUNCT
admet-557	113	10	darolutamide	darolutamide	NOUN
admet-557	113	11	,	,	PUNCT
admet-557	113	12	orm-15341	orm-15341	NOUN
admet-557	113	13	and	and	CCONJ
admet-557	113	14	the	the	PRON
admet-557	113	15	is	be	AUX
admet-557	113	16	in	in	ADP
admet-557	113	17	the	the	DET
admet-557	113	18	injection	injection	NOUN
admet-557	113	19	solvent	solvent	NOUN
admet-557	113	20	was	be	AUX
admet-557	113	21	determined	determine	VERB
admet-557	113	22	periodically	periodically	ADV
admet-557	113	23	by	by	ADP
admet-557	113	24	injecting	inject	VERB
admet-557	113	25	replicate	replicate	ADJ
admet-557	113	26	preparations	preparation	NOUN
admet-557	113	27	of	of	ADP
admet-557	113	28	processed	process	VERB
admet-557	113	29	dbs	dbs	NOUN
admet-557	113	30	samples	sample	NOUN
admet-557	113	31	for	for	ADP
admet-557	113	32	up	up	ADP
admet-557	113	33	to	to	PART
admet-557	113	34	24	24	NUM
admet-557	113	35	h	h	NOUN
admet-557	113	36	(	(	PUNCT
admet-557	113	37	in	in	ADP
admet-557	113	38	the	the	DET
admet-557	113	39	auto	auto	NOUN
admet-557	113	40	-	-	PUNCT
admet-557	113	41	sampler	sampler	NOUN
admet-557	113	42	at	at	ADP
admet-557	113	43	5	5	NUM
admet-557	113	44	°	°	NOUN
admet-557	113	45	c	c	NOUN
admet-557	113	46	)	)	PUNCT
admet-557	113	47	after	after	ADP
admet-557	113	48	the	the	DET
admet-557	113	49	initial	initial	ADJ
admet-557	113	50	injection	injection	NOUN
admet-557	113	51	.	.	PUNCT
admet-557	114	1	dilution	dilution	NOUN
admet-557	114	2	effect	effect	NOUN
admet-557	114	3	to	to	PART
admet-557	114	4	evaluate	evaluate	VERB
admet-557	114	5	the	the	DET
admet-557	114	6	effect	effect	NOUN
admet-557	114	7	of	of	ADP
admet-557	114	8	dilution	dilution	NOUN
admet-557	114	9	over	over	ADP
admet-557	114	10	the	the	DET
admet-557	114	11	calibration	calibration	NOUN
admet-557	114	12	range	range	NOUN
admet-557	114	13	,	,	PUNCT
admet-557	114	14	the	the	DET
admet-557	114	15	accuracy	accuracy	NOUN
admet-557	114	16	and	and	CCONJ
admet-557	114	17	precision	precision	NOUN
admet-557	114	18	of	of	ADP
admet-557	114	19	dilution	dilution	NOUN
admet-557	114	20	control	control	NOUN
admet-557	114	21	samples	sample	NOUN
admet-557	114	22	at	at	ADP
admet-557	114	23	10,000	10,000	NUM
admet-557	114	24	ng	ng	NOUN
admet-557	114	25	/	/	SYM
admet-557	114	26	ml	ml	PROPN
admet-557	114	27	(	(	PUNCT
admet-557	114	28	n	n	NOUN
admet-557	114	29	=	=	SYM
admet-557	114	30	6	6	NUM
admet-557	114	31	;	;	PUNCT
admet-557	114	32	5	5	NUM
admet-557	114	33	times	time	NOUN
admet-557	114	34	of	of	ADP
admet-557	114	35	the	the	DET
admet-557	114	36	uloq	uloq	NOUN
admet-557	114	37	)	)	PUNCT
admet-557	114	38	were	be	AUX
admet-557	114	39	assessed	assess	VERB
admet-557	114	40	by	by	ADP
admet-557	114	41	performing	perform	VERB
admet-557	114	42	a	a	DET
admet-557	114	43	10	10	NUM
admet-557	114	44	-	-	ADJ
admet-557	114	45	fold	fold	ADJ
admet-557	114	46	dilution	dilution	NOUN
admet-557	114	47	.	.	PUNCT
admet-557	115	1	influence	influence	NOUN
admet-557	115	2	of	of	ADP
admet-557	115	3	hematocrit	hematocrit	PROPN
admet-557	115	4	hematocrit	hematocrit	PROPN
admet-557	115	5	(	(	PUNCT
admet-557	115	6	hct	hct	PROPN
admet-557	115	7	)	)	PUNCT
admet-557	115	8	has	have	VERB
admet-557	115	9	a	a	DET
admet-557	115	10	significant	significant	ADJ
admet-557	115	11	effect	effect	NOUN
admet-557	115	12	on	on	ADP
admet-557	115	13	the	the	DET
admet-557	115	14	viscosity	viscosity	NOUN
admet-557	115	15	of	of	ADP
admet-557	115	16	the	the	DET
admet-557	115	17	blood	blood	NOUN
admet-557	115	18	,	,	PUNCT
admet-557	115	19	which	which	PRON
admet-557	115	20	influences	influence	VERB
admet-557	115	21	the	the	DET
admet-557	115	22	flux	flux	NOUN
admet-557	115	23	and	and	CCONJ
admet-557	115	24	diffusion	diffusion	NOUN
admet-557	115	25	properties	property	NOUN
admet-557	115	26	of	of	ADP
admet-557	115	27	the	the	DET
admet-557	115	28	blood	blood	NOUN
admet-557	115	29	through	through	ADP
admet-557	115	30	dbs	dbs	PROPN
admet-557	115	31	card	card	NOUN
admet-557	115	32	used	use	VERB
admet-557	115	33	for	for	ADP
admet-557	115	34	sample	sample	NOUN
admet-557	115	35	collection	collection	NOUN
admet-557	115	36	.	.	PUNCT
admet-557	116	1	it	it	PRON
admet-557	116	2	can	can	AUX
admet-557	116	3	directly	directly	ADV
admet-557	116	4	affect	affect	VERB
admet-557	116	5	the	the	DET
admet-557	116	6	accuracy	accuracy	NOUN
admet-557	116	7	of	of	ADP
admet-557	116	8	the	the	DET
admet-557	116	9	analysis	analysis	NOUN
admet-557	116	10	in	in	ADP
admet-557	116	11	dbs	dbs	PROPN
admet-557	116	12	samples	sample	NOUN
admet-557	116	13	.	.	PUNCT
admet-557	117	1	hct	hct	NOUN
admet-557	117	2	is	be	AUX
admet-557	117	3	normally	normally	ADV
admet-557	117	4	about	about	ADV
admet-557	117	5	43	43	NUM
admet-557	117	6	-	-	SYM
admet-557	117	7	48	48	NUM
admet-557	117	8	for	for	ADP
admet-557	117	9	balb	balb	ADJ
admet-557	117	10	/	/	SYM
admet-557	117	11	c	c	NOUN
admet-557	117	12	mice	mouse	NOUN
admet-557	117	13	(	(	PUNCT
admet-557	117	14	in	in	ADP
admet-557	117	15	house	house	NOUN
admet-557	117	16	data	data	PROPN
admet-557	117	17	)	)	PUNCT
admet-557	117	18	.	.	PUNCT
admet-557	118	1	the	the	DET
admet-557	118	2	effect	effect	NOUN
admet-557	118	3	of	of	ADP
admet-557	118	4	the	the	DET
admet-557	118	5	hct	hct	NOUN
admet-557	118	6	on	on	ADP
admet-557	118	7	analytical	analytical	ADJ
admet-557	118	8	performance	performance	NOUN
admet-557	118	9	was	be	AUX
admet-557	118	10	investigated	investigate	VERB
admet-557	118	11	by	by	ADP
admet-557	118	12	measuring	measure	VERB
admet-557	118	13	lqcs	lqcs	ADJ
admet-557	118	14	and	and	CCONJ
admet-557	118	15	hqcs	hqc	NOUN
admet-557	118	16	spiked	spike	VERB
admet-557	118	17	in	in	ADP
admet-557	118	18	six	six	NUM
admet-557	118	19	different	different	ADJ
admet-557	118	20	sources	source	NOUN
admet-557	118	21	of	of	ADP
admet-557	118	22	blood	blood	NOUN
admet-557	118	23	adjusted	adjust	VERB
admet-557	118	24	with	with	ADP
admet-557	118	25	plasma	plasma	NOUN
admet-557	118	26	to	to	PART
admet-557	118	27	obtain	obtain	VERB
admet-557	118	28	values	value	NOUN
admet-557	118	29	at	at	ADP
admet-557	118	30	25	25	NUM
admet-557	118	31	,	,	PUNCT
admet-557	118	32	35	35	NUM
admet-557	118	33	and	and	CCONJ
admet-557	118	34	45	45	NUM
admet-557	118	35	%	%	NOUN
admet-557	118	36	haematocrit	haematocrit	NOUN
admet-557	118	37	that	that	PRON
admet-557	118	38	were	be	AUX
admet-557	118	39	analysed	analyse	VERB
admet-557	118	40	with	with	ADP
admet-557	118	41	calibrators	calibrator	NOUN
admet-557	118	42	prepared	prepare	VERB
admet-557	118	43	in	in	ADP
admet-557	118	44	blood	blood	NOUN
admet-557	118	45	at	at	ADP
admet-557	118	46	standard	standard	ADJ
admet-557	118	47	fixed	fix	VERB
admet-557	118	48	40	40	NUM
admet-557	118	49	%	%	NOUN
admet-557	118	50	hct	hct	PROPN
admet-557	118	51	.	.	PUNCT
admet-557	119	1	the	the	DET
admet-557	119	2	relative	relative	ADJ
admet-557	119	3	error	error	NOUN
admet-557	119	4	of	of	ADP
admet-557	119	5	±15	±15	NOUN
admet-557	119	6	%	%	NOUN
admet-557	119	7	and	and	CCONJ
admet-557	119	8	precision	precision	NOUN
admet-557	119	9	of	of	ADP
admet-557	119	10	≤15	≤15	NOUN
admet-557	119	11	%	%	NOUN
admet-557	119	12	was	be	AUX
admet-557	119	13	considered	consider	VERB
admet-557	119	14	acceptable	acceptable	ADJ
admet-557	119	15	.	.	PUNCT
admet-557	120	1	hematocrits	hematocrit	NOUN
admet-557	120	2	were	be	AUX
admet-557	120	3	measured	measure	VERB
admet-557	120	4	using	use	VERB
admet-557	120	5	mindray	mindray	NOUN
admet-557	120	6	bc-5000vet	bc-5000vet	PROPN
admet-557	120	7	.	.	PUNCT
admet-557	121	1	pharmacokinetic	pharmacokinetic	ADJ
admet-557	121	2	study	study	NOUN
admet-557	121	3	all	all	DET
admet-557	121	4	the	the	DET
admet-557	121	5	animal	animal	NOUN
admet-557	121	6	experiments	experiment	NOUN
admet-557	121	7	were	be	AUX
admet-557	121	8	approved	approve	VERB
admet-557	121	9	by	by	ADP
admet-557	121	10	institutional	institutional	ADJ
admet-557	121	11	animal	animal	NOUN
admet-557	121	12	ethical	ethical	PROPN
admet-557	121	13	committee	committee	NOUN
admet-557	121	14	(	(	PUNCT
admet-557	121	15	iaec	iaec	PROPN
admet-557	121	16	/	/	SYM
admet-557	121	17	jdc/2017/133	jdc/2017/133	NOUN
admet-557	121	18	)	)	PUNCT
admet-557	121	19	.	.	PUNCT
admet-557	122	1	male	male	ADJ
admet-557	122	2	balb	balb	NOUN
admet-557	122	3	/	/	SYM
admet-557	122	4	c	c	NOUN
admet-557	122	5	mice	mouse	NOUN
admet-557	122	6	(	(	PUNCT
admet-557	122	7	n	n	NOUN
admet-557	122	8	=	=	SYM
admet-557	122	9	12	12	NUM
admet-557	122	10	)	)	PUNCT
admet-557	122	11	purchased	purchase	VERB
admet-557	122	12	from	from	ADP
admet-557	122	13	vivo	vivo	ADJ
admet-557	122	14	biotech	biotech	NOUN
admet-557	122	15	,	,	PUNCT
admet-557	122	16	hyderabad	hyderabad	PROPN
admet-557	122	17	were	be	AUX
admet-557	122	18	housed	house	VERB
admet-557	122	19	in	in	ADP
admet-557	122	20	jubilant	jubilant	ADJ
admet-557	122	21	biosys	biosys	NOUN
admet-557	122	22	animal	animal	PROPN
admet-557	122	23	house	house	NOUN
admet-557	122	24	facility	facility	NOUN
admet-557	122	25	in	in	ADP
admet-557	122	26	a	a	DET
admet-557	122	27	temperature	temperature	NOUN
admet-557	122	28	(	(	PUNCT
admet-557	122	29	22	22	NUM
admet-557	122	30	±	±	NUM
admet-557	122	31	1	1	NUM
admet-557	122	32	°	°	ADP
admet-557	122	33	c	c	NOUN
admet-557	122	34	)	)	PUNCT
admet-557	122	35	and	and	CCONJ
admet-557	122	36	humidity	humidity	NOUN
admet-557	122	37	(	(	PUNCT
admet-557	122	38	30	30	NUM
admet-557	122	39	-	-	SYM
admet-557	122	40	70	70	NUM
admet-557	122	41	%	%	NOUN
admet-557	122	42	)	)	PUNCT
admet-557	122	43	controlled	control	VERB
admet-557	122	44	room	room	NOUN
admet-557	122	45	(	(	PUNCT
admet-557	122	46	15	15	NUM
admet-557	122	47	air	air	NOUN
admet-557	122	48	changes	change	NOUN
admet-557	122	49	/	/	SYM
admet-557	122	50	h	h	NOUN
admet-557	122	51	)	)	PUNCT
admet-557	122	52	with	with	ADP
admet-557	122	53	a	a	DET
admet-557	122	54	12:12	12:12	NUM
admet-557	122	55	h	h	NOUN
admet-557	122	56	light	light	NOUN
admet-557	122	57	:	:	PUNCT
admet-557	122	58	dark	dark	ADJ
admet-557	122	59	cycles	cycle	NOUN
admet-557	122	60	,	,	PUNCT
admet-557	122	61	had	have	VERB
admet-557	122	62	free	free	ADJ
admet-557	122	63	access	access	NOUN
admet-557	122	64	to	to	ADP
admet-557	122	65	rodent	rodent	ADJ
admet-557	122	66	feed	feed	NOUN
admet-557	122	67	(	(	PUNCT
admet-557	122	68	altromin	altromin	NOUN
admet-557	122	69	spezialfutter	spezialfutter	PROPN
admet-557	122	70	gmbh	gmbh	PROPN
admet-557	122	71	&	&	CCONJ
admet-557	122	72	co.	co.	PROPN
admet-557	123	1	kg	kg	PROPN
admet-557	123	2	.	.	PROPN
admet-557	123	3	,	,	PUNCT
admet-557	124	1	i	i	PRON
admet-557	124	2	m	m	VERB
admet-557	124	3	seelenkamp	seelenkamp	ADJ
admet-557	124	4	20	20	NUM
admet-557	124	5	,	,	PUNCT
admet-557	124	6	d-32791	d-32791	PROPN
admet-557	124	7	,	,	PUNCT
admet-557	124	8	lage	lage	NOUN
admet-557	124	9	,	,	PUNCT
admet-557	124	10	germany	germany	PROPN
admet-557	124	11	)	)	PUNCT
admet-557	124	12	and	and	CCONJ
admet-557	124	13	water	water	NOUN
admet-557	124	14	for	for	ADP
admet-557	124	15	one	one	NUM
admet-557	124	16	week	week	NOUN
admet-557	124	17	before	before	ADP
admet-557	124	18	using	use	VERB
admet-557	124	19	for	for	ADP
admet-557	124	20	experimental	experimental	ADJ
admet-557	124	21	purpose	purpose	NOUN
admet-557	124	22	.	.	PUNCT
admet-557	125	1	following	follow	VERB
admet-557	125	2	~4	~4	NOUN
admet-557	126	1	h	h	ADV
admet-557	127	1	fast	fast	ADV
admet-557	128	1	(	(	PUNCT
admet-557	128	2	during	during	ADP
admet-557	128	3	the	the	DET
admet-557	128	4	fasting	fast	VERB
admet-557	128	5	period	period	NOUN
admet-557	128	6	animals	animal	NOUN
admet-557	128	7	had	have	VERB
admet-557	128	8	free	free	ADJ
admet-557	128	9	access	access	NOUN
admet-557	128	10	to	to	ADP
admet-557	128	11	water	water	NOUN
admet-557	128	12	)	)	PUNCT
admet-557	128	13	mice	mouse	NOUN
admet-557	128	14	(	(	PUNCT
admet-557	128	15	25	25	NUM
admet-557	128	16	-	-	SYM
admet-557	128	17	32	32	NUM
admet-557	128	18	g	g	NOUN
admet-557	128	19	)	)	PUNCT
admet-557	128	20	received	receive	VERB
admet-557	128	21	enzalutamide	enzalutamide	ADV
admet-557	128	22	and	and	CCONJ
admet-557	128	23	darolutamide	darolutamide	VERB
admet-557	128	24	intravenously	intravenously	ADV
admet-557	128	25	[	[	X
admet-557	128	26	5	5	NUM
admet-557	128	27	%	%	NOUN
admet-557	128	28	dmso	dmso	NOUN
admet-557	128	29	,	,	PUNCT
admet-557	128	30	5	5	NUM
admet-557	128	31	%	%	NOUN
admet-557	128	32	solutol	solutol	NOUN
admet-557	128	33	:	:	PUNCT
admet-557	128	34	absolute	absolute	ADJ
admet-557	128	35	alcohol	alcohol	NOUN
admet-557	128	36	(	(	PUNCT
admet-557	128	37	1:1	1:1	NUM
admet-557	128	38	,	,	PUNCT
admet-557	128	39	v	v	NOUN
admet-557	128	40	/	/	SYM
admet-557	128	41	v	v	NOUN
admet-557	128	42	)	)	PUNCT
admet-557	128	43	and	and	CCONJ
admet-557	128	44	90	90	NUM
admet-557	128	45	%	%	NOUN
admet-557	128	46	of	of	ADP
admet-557	128	47	normal	normal	ADJ
admet-557	128	48	saline	saline	NOUN
admet-557	128	49	;	;	PUNCT
admet-557	128	50	strength	strength	NOUN
admet-557	128	51	:	:	PUNCT
admet-557	128	52	0.1	0.1	NUM
admet-557	128	53	mg	mg	NUM
admet-557	128	54	/	/	SYM
admet-557	128	55	ml	ml	PROPN
admet-557	128	56	;	;	PUNCT
admet-557	128	57	dose	dose	NOUN
admet-557	128	58	volume	volume	NOUN
admet-557	128	59	:	:	PUNCT
admet-557	128	60	10	10	NUM
admet-557	128	61	ml	ml	NOUN
admet-557	128	62	/	/	SYM
admet-557	128	63	kg	kg	NOUN
admet-557	128	64	]	]	X
admet-557	128	65	as	as	ADP
admet-557	128	66	a	a	DET
admet-557	128	67	cassette	cassette	NOUN
admet-557	128	68	dose	dose	VERB
admet-557	128	69	at	at	ADP
admet-557	128	70	1.0	1.0	NUM
admet-557	128	71	mg	mg	PROPN
admet-557	128	72	/	/	SYM
admet-557	128	73	kg	kg	PROPN
admet-557	128	74	.	.	PUNCT
admet-557	129	1	post	post	ADJ
admet-557	129	2	-	-	ADJ
admet-557	129	3	dosing	dosing	ADJ
admet-557	129	4	serial	serial	ADJ
admet-557	129	5	blood	blood	NOUN
admet-557	129	6	samples	sample	NOUN
admet-557	129	7	(	(	PUNCT
admet-557	129	8	25	25	NUM
admet-557	129	9	µl	µl	NOUN
admet-557	129	10	,	,	PUNCT
admet-557	129	11	sparse	sparse	ADJ
admet-557	129	12	sampling	sampling	NOUN
admet-557	129	13	was	be	AUX
admet-557	129	14	done	do	VERB
admet-557	129	15	and	and	CCONJ
admet-557	129	16	at	at	ADP
admet-557	129	17	each	each	DET
admet-557	129	18	time	time	NOUN
admet-557	129	19	point	point	NOUN
admet-557	129	20	three	three	NUM
admet-557	129	21	mice	mouse	NOUN
admet-557	129	22	were	be	AUX
admet-557	129	23	used	use	VERB
admet-557	129	24	for	for	ADP
admet-557	129	25	blood	blood	NOUN
admet-557	129	26	sampling	sampling	NOUN
admet-557	129	27	)	)	PUNCT
admet-557	129	28	were	be	AUX
admet-557	129	29	collected	collect	VERB
admet-557	129	30	at	at	ADP
admet-557	129	31	regular	regular	ADJ
admet-557	129	32	intervals	interval	NOUN
admet-557	129	33	using	use	VERB
admet-557	129	34	micropipettes	micropipette	NOUN
admet-557	129	35	(	(	PUNCT
admet-557	129	36	microcaps	microcap	NOUN
admet-557	129	37	®	®	NOUN
admet-557	129	38	;	;	PUNCT
admet-557	129	39	catalogue	catalogue	NOUN
admet-557	129	40	number	number	NOUN
admet-557	129	41	:	:	PUNCT
admet-557	129	42	1	1	NUM
admet-557	129	43	-	-	PUNCT
admet-557	129	44	000	000	NUM
admet-557	129	45	-	-	PUNCT
admet-557	129	46	0500	0500	NUM
admet-557	129	47	)	)	PUNCT
admet-557	129	48	through	through	ADP
admet-557	129	49	tail	tail	NOUN
admet-557	129	50	vein	vein	NOUN
admet-557	129	51	into	into	ADP
admet-557	129	52	polypropylene	polypropylene	NOUN
admet-557	129	53	tubes	tube	NOUN
admet-557	129	54	containing	contain	VERB
admet-557	129	55	k2.edta	k2.edta	NOUN
admet-557	129	56	solution	solution	NOUN
admet-557	129	57	as	as	ADP
admet-557	129	58	an	an	DET
admet-557	129	59	anti	anti	ADJ
admet-557	129	60	-	-	ADJ
admet-557	129	61	coagulant	coagulant	ADJ
admet-557	129	62	0.12	0.12	NUM
admet-557	129	63	,	,	PUNCT
admet-557	129	64	0.25	0.25	NUM
admet-557	129	65	,	,	PUNCT
admet-557	129	66	0.5	0.5	NUM
admet-557	129	67	,	,	PUNCT
admet-557	129	68	1	1	NUM
admet-557	129	69	,	,	PUNCT
admet-557	129	70	2	2	NUM
admet-557	129	71	,	,	PUNCT
admet-557	129	72	4	4	NUM
admet-557	129	73	,	,	PUNCT
admet-557	129	74	8	8	NUM
admet-557	129	75	,	,	PUNCT
admet-557	129	76	24	24	NUM
admet-557	129	77	,	,	PUNCT
admet-557	129	78	48	48	NUM
admet-557	129	79	,	,	PUNCT
admet-557	129	80	72	72	NUM
admet-557	129	81	,	,	PUNCT
admet-557	129	82	96	96	NUM
admet-557	129	83	,	,	PUNCT
admet-557	129	84	120	120	NUM
admet-557	129	85	,	,	PUNCT
admet-557	129	86	144	144	NUM
admet-557	129	87	and	and	CCONJ
admet-557	129	88	168	168	NUM
admet-557	129	89	h	h	NOUN
admet-557	129	90	and	and	CCONJ
admet-557	129	91	spotted	spot	VERB
admet-557	129	92	onto	onto	ADP
admet-557	129	93	the	the	DET
admet-557	129	94	cards	card	NOUN
admet-557	129	95	and	and	CCONJ
admet-557	129	96	air	air	NOUN
admet-557	129	97	dried	dry	VERB
admet-557	129	98	at	at	ADP
admet-557	129	99	room	room	NOUN
admet-557	129	100	temperature	temperature	NOUN
admet-557	129	101	for	for	ADP
admet-557	129	102	3	3	NUM
admet-557	129	103	h	h	NOUN
admet-557	129	104	before	before	ADP
admet-557	129	105	storing	store	VERB
admet-557	129	106	at	at	ADP
admet-557	129	107	controlled	control	VERB
admet-557	129	108	room	room	NOUN
admet-557	129	109	temperature	temperature	NOUN
admet-557	129	110	(	(	PUNCT
admet-557	129	111	25	25	NUM
admet-557	129	112	°	°	NOUN
admet-557	129	113	c	c	NOUN
admet-557	129	114	)	)	PUNCT
admet-557	129	115	until	until	ADP
admet-557	129	116	analysis	analysis	NOUN
admet-557	129	117	.	.	PUNCT
admet-557	130	1	animals	animal	NOUN
admet-557	130	2	were	be	AUX
admet-557	130	3	allowed	allow	VERB
admet-557	130	4	to	to	PART
admet-557	130	5	eat	eat	VERB
admet-557	130	6	feed	feed	NOUN
admet-557	130	7	2	2	NUM
admet-557	130	8	h	h	NOUN
admet-557	130	9	post	post	NOUN
admet-557	130	10	-	-	ADJ
admet-557	130	11	dose	dose	NOUN
admet-557	130	12	of	of	ADP
admet-557	130	13	enzalutamide	enzalutamide	ADV
admet-557	130	14	and	and	CCONJ
admet-557	130	15	darolutamide	darolutamide	ADV
admet-557	130	16	.	.	PUNCT
admet-557	131	1	the	the	DET
admet-557	131	2	criteria	criterion	NOUN
admet-557	131	3	for	for	ADP
admet-557	131	4	acceptance	acceptance	NOUN
admet-557	131	5	of	of	ADP
admet-557	131	6	the	the	DET
admet-557	131	7	analytical	analytical	ADJ
admet-557	131	8	runs	run	NOUN
admet-557	131	9	encompassed	encompass	VERB
admet-557	131	10	the	the	DET
admet-557	131	11	following	following	NOUN
admet-557	131	12	:	:	PUNCT
admet-557	131	13	(	(	PUNCT
admet-557	131	14	i	i	NOUN
admet-557	131	15	)	)	PUNCT
admet-557	131	16	67	67	NUM
admet-557	131	17	%	%	NOUN
admet-557	131	18	of	of	ADP
admet-557	131	19	the	the	DET
admet-557	131	20	qc	qc	PROPN
admet-557	131	21	samples	sample	NOUN
admet-557	131	22	accuracy	accuracy	NOUN
admet-557	131	23	must	must	AUX
admet-557	131	24	be	be	AUX
admet-557	131	25	within	within	ADP
admet-557	131	26	85	85	NUM
admet-557	131	27	-	-	SYM
admet-557	131	28	115	115	NUM
admet-557	131	29	%	%	NOUN
admet-557	131	30	of	of	ADP
admet-557	131	31	the	the	DET
admet-557	131	32	nominal	nominal	ADJ
admet-557	131	33	concentration	concentration	NOUN
admet-557	131	34	(	(	PUNCT
admet-557	131	35	ii	ii	NOUN
admet-557	131	36	)	)	PUNCT
admet-557	131	37	not	not	PART
admet-557	131	38	less	less	ADJ
admet-557	131	39	than	than	ADP
admet-557	131	40	50	50	NUM
admet-557	131	41	%	%	NOUN
admet-557	131	42	at	at	ADP
admet-557	131	43	each	each	DET
admet-557	131	44	qc	qc	PROPN
admet-557	131	45	concentration	concentration	NOUN
admet-557	131	46	level	level	NOUN
admet-557	131	47	must	must	AUX
admet-557	131	48	meet	meet	VERB
admet-557	131	49	the	the	DET
admet-557	131	50	acceptance	acceptance	NOUN
admet-557	131	51	criteria	criterion	NOUN
admet-557	131	52	[	[	X
admet-557	131	53	27	27	NUM
admet-557	131	54	]	]	PUNCT
admet-557	131	55	.	.	PUNCT
admet-557	132	1	blood	blood	NOUN
admet-557	132	2	concentration	concentration	NOUN
admet-557	132	3	versus	versus	ADP
admet-557	132	4	time	time	NOUN
admet-557	132	5	data	datum	NOUN
admet-557	132	6	of	of	ADP
admet-557	132	7	r.	r.	PROPN
admet-557	132	8	mullangi	mullangi	PROPN
admet-557	132	9	et	et	PROPN
admet-557	132	10	al	al	PROPN
admet-557	132	11	.	.	PROPN
admet-557	132	12	admet	admet	PROPN
admet-557	132	13	&	&	CCONJ
admet-557	132	14	dmpk	dmpk	PROPN
admet-557	132	15	6(3	6(3	PROPN
admet-557	132	16	)	)	PUNCT
admet-557	132	17	(	(	PUNCT
admet-557	132	18	2018	2018	NUM
admet-557	132	19	)	)	PUNCT
admet-557	132	20	242	242	NUM
admet-557	132	21	-	-	SYM
admet-557	132	22	257	257	NUM
admet-557	132	23	248	248	NUM
admet-557	132	24	enzalutamide	enzalutamide	ADV
admet-557	132	25	,	,	PUNCT
admet-557	132	26	darolutamide	darolutamide	NOUN
admet-557	132	27	and	and	CCONJ
admet-557	132	28	orm-15341	orm-15341	NOUN
admet-557	132	29	was	be	AUX
admet-557	132	30	analyzed	analyze	VERB
admet-557	132	31	by	by	ADP
admet-557	132	32	non	non	ADJ
admet-557	132	33	-	-	ADJ
admet-557	132	34	compartmental	compartmental	ADJ
admet-557	132	35	method	method	NOUN
admet-557	132	36	using	use	VERB
admet-557	132	37	phoenix	phoenix	PROPN
admet-557	132	38	winnonlin	winnonlin	PROPN
admet-557	132	39	version	version	PROPN
admet-557	132	40	7.0	7.0	NUM
admet-557	132	41	.	.	PUNCT
admet-557	132	42	results	result	VERB
admet-557	132	43	ms	ms	PROPN
admet-557	132	44	/	/	SYM
admet-557	132	45	ms	ms	NOUN
admet-557	132	46	conditions	condition	NOUN
admet-557	132	47	and	and	CCONJ
admet-557	132	48	chromatography	chromatography	NOUN
admet-557	132	49	the	the	DET
admet-557	132	50	optimum	optimum	ADJ
admet-557	132	51	lc	lc	PROPN
admet-557	132	52	-	-	PUNCT
admet-557	132	53	ms	ms	PROPN
admet-557	132	54	/	/	SYM
admet-557	132	55	ms	ms	PROPN
admet-557	132	56	mobile	mobile	ADJ
admet-557	132	57	phase	phase	NOUN
admet-557	132	58	was	be	AUX
admet-557	132	59	determined	determine	VERB
admet-557	132	60	through	through	ADP
admet-557	132	61	several	several	ADJ
admet-557	132	62	trials	trial	NOUN
admet-557	132	63	to	to	PART
admet-557	132	64	achieve	achieve	VERB
admet-557	132	65	good	good	ADJ
admet-557	132	66	resolution	resolution	NOUN
admet-557	132	67	and	and	CCONJ
admet-557	132	68	symmetric	symmetric	ADJ
admet-557	132	69	peak	peak	NOUN
admet-557	132	70	shapes	shape	NOUN
admet-557	132	71	for	for	ADP
admet-557	132	72	the	the	DET
admet-557	132	73	analytes	analyte	NOUN
admet-557	132	74	and	and	CCONJ
admet-557	132	75	the	the	PRON
admet-557	132	76	is	be	AUX
admet-557	132	77	in	in	ADP
admet-557	132	78	short	short	ADJ
admet-557	132	79	run	run	NOUN
admet-557	132	80	time	time	NOUN
admet-557	132	81	.	.	PUNCT
admet-557	133	1	to	to	PART
admet-557	133	2	obtain	obtain	VERB
admet-557	133	3	good	good	ADJ
admet-557	133	4	separation	separation	NOUN
admet-557	133	5	,	,	PUNCT
admet-557	133	6	resolution	resolution	NOUN
admet-557	133	7	and	and	CCONJ
admet-557	133	8	peak	peak	NOUN
admet-557	133	9	shape	shape	NOUN
admet-557	133	10	for	for	ADP
admet-557	133	11	enzalutamide	enzalutamide	NOUN
admet-557	133	12	,	,	PUNCT
admet-557	133	13	n	n	CCONJ
admet-557	133	14	-	-	PUNCT
admet-557	133	15	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	133	16	,	,	PUNCT
admet-557	133	17	darolutamide	darolutamide	NOUN
admet-557	133	18	,	,	PUNCT
admet-557	133	19	orm15341	orm15341	NOUN
admet-557	133	20	and	and	CCONJ
admet-557	133	21	the	the	PRON
admet-557	133	22	is	be	AUX
admet-557	134	1	isocratic	isocratic	ADJ
admet-557	134	2	elution	elution	NOUN
admet-557	134	3	was	be	AUX
admet-557	134	4	used	use	VERB
admet-557	134	5	at	at	ADP
admet-557	134	6	a	a	DET
admet-557	134	7	flow	flow	NOUN
admet-557	134	8	rate	rate	NOUN
admet-557	134	9	0.8	0.8	NUM
admet-557	134	10	ml	ml	NOUN
admet-557	134	11	/	/	SYM
admet-557	134	12	min	min	NOUN
admet-557	134	13	.	.	PROPN
admet-557	135	1	among	among	ADP
admet-557	135	2	the	the	DET
admet-557	135	3	several	several	ADJ
admet-557	135	4	commercial	commercial	ADJ
admet-557	135	5	columns	column	NOUN
admet-557	135	6	(	(	PUNCT
admet-557	135	7	inertsil	inertsil	PROPN
admet-557	135	8	,	,	PUNCT
admet-557	135	9	atlantis	atlantis	PROPN
admet-557	135	10	,	,	PUNCT
admet-557	135	11	kromasil	kromasil	PROPN
admet-557	135	12	,	,	PUNCT
admet-557	135	13	hypersil	hypersil	NOUN
admet-557	135	14	etc	etc	X
admet-557	135	15	.	.	X
admet-557	135	16	)	)	PUNCT
admet-557	135	17	tested	test	VERB
admet-557	135	18	,	,	PUNCT
admet-557	135	19	an	an	DET
admet-557	135	20	atlantis	atlantis	PROPN
admet-557	135	21	dc18	dc18	PROPN
admet-557	135	22	column	column	NOUN
admet-557	135	23	(	(	PUNCT
admet-557	135	24	50	50	NUM
admet-557	135	25	x	x	SYM
admet-557	135	26	4.6	4.6	NUM
admet-557	135	27	mm	mm	NOUN
admet-557	135	28	,	,	PUNCT
admet-557	135	29	5	5	NUM
admet-557	135	30	µm	µm	NOUN
admet-557	135	31	)	)	PUNCT
admet-557	135	32	was	be	AUX
admet-557	135	33	selected	select	VERB
admet-557	135	34	because	because	SCONJ
admet-557	135	35	it	it	PRON
admet-557	135	36	provided	provide	VERB
admet-557	135	37	symmetric	symmetric	ADJ
admet-557	135	38	peaks	peak	NOUN
admet-557	135	39	and	and	CCONJ
admet-557	135	40	baseline	baseline	NOUN
admet-557	135	41	separation	separation	NOUN
admet-557	135	42	of	of	ADP
admet-557	135	43	enzalutamide	enzalutamide	NOUN
admet-557	135	44	,	,	PUNCT
admet-557	135	45	n	n	CCONJ
admet-557	135	46	-	-	PUNCT
admet-557	135	47	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	135	48	,	,	PUNCT
admet-557	135	49	darolutamide	darolutamide	NOUN
admet-557	135	50	,	,	PUNCT
admet-557	135	51	orm-15341	orm-15341	NOUN
admet-557	135	52	and	and	CCONJ
admet-557	135	53	the	the	PRON
admet-557	135	54	is	be	AUX
admet-557	135	55	within	within	ADP
admet-557	135	56	2.5	2.5	NUM
admet-557	135	57	min	min	NOUN
admet-557	135	58	run	run	NOUN
admet-557	135	59	time	time	NOUN
admet-557	135	60	.	.	PUNCT
admet-557	136	1	the	the	DET
admet-557	136	2	ms	ms	PROPN
admet-557	136	3	/	/	SYM
admet-557	136	4	ms	ms	PROPN
admet-557	136	5	ion	ion	NOUN
admet-557	136	6	transitions	transition	NOUN
admet-557	136	7	monitored	monitor	VERB
admet-557	136	8	were	be	AUX
admet-557	136	9	m	m	PROPN
admet-557	136	10	/	/	SYM
admet-557	136	11	z	z	PROPN
admet-557	136	12	465→209	465→209	PROPN
admet-557	136	13	,	,	PUNCT
admet-557	136	14	m	m	PROPN
admet-557	136	15	/	/	SYM
admet-557	136	16	z	z	PROPN
admet-557	136	17	451→195	451→195	PROPN
admet-557	136	18	,	,	PUNCT
admet-557	136	19	m	m	PROPN
admet-557	136	20	/	/	SYM
admet-557	136	21	z	z	PROPN
admet-557	136	22	399→178	399→178	PROPN
admet-557	136	23	,	,	PUNCT
admet-557	136	24	m	m	PROPN
admet-557	136	25	/	/	SYM
admet-557	136	26	z	z	PROPN
admet-557	136	27	397→194	397→194	NUM
admet-557	136	28	and	and	CCONJ
admet-557	136	29	m	m	PROPN
admet-557	136	30	/	/	SYM
admet-557	136	31	z	z	PROPN
admet-557	136	32	481→453	481→453	PROPN
admet-557	136	33	for	for	ADP
admet-557	136	34	enzalutamide	enzalutamide	NOUN
admet-557	136	35	,	,	PUNCT
admet-557	136	36	n	n	CCONJ
admet-557	136	37	-	-	PUNCT
admet-557	136	38	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	136	39	,	,	PUNCT
admet-557	136	40	darolutamide	darolutamide	NOUN
admet-557	136	41	,	,	PUNCT
admet-557	136	42	orm-15341	orm-15341	NOUN
admet-557	136	43	and	and	CCONJ
admet-557	136	44	the	the	PRON
admet-557	136	45	is	be	AUX
admet-557	136	46	,	,	PUNCT
admet-557	136	47	respectively	respectively	ADV
admet-557	136	48	for	for	ADP
admet-557	136	49	quantitation	quantitation	NOUN
admet-557	136	50	.	.	PUNCT
admet-557	137	1	the	the	DET
admet-557	137	2	retention	retention	NOUN
admet-557	137	3	time	time	NOUN
admet-557	137	4	of	of	ADP
admet-557	137	5	enzalutamide	enzalutamide	NOUN
admet-557	137	6	,	,	PUNCT
admet-557	137	7	n	n	CCONJ
admet-557	137	8	-	-	PUNCT
admet-557	137	9	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	137	10	,	,	PUNCT
admet-557	137	11	darolutamide	darolutamide	NOUN
admet-557	137	12	,	,	PUNCT
admet-557	137	13	orm-15341	orm-15341	NOUN
admet-557	137	14	and	and	CCONJ
admet-557	137	15	the	the	PRON
admet-557	137	16	is	be	AUX
admet-557	137	17	was	be	AUX
admet-557	137	18	1.32	1.32	NUM
admet-557	137	19	,	,	PUNCT
admet-557	137	20	1.23	1.23	NUM
admet-557	137	21	,	,	PUNCT
admet-557	137	22	1.01	1.01	NUM
admet-557	137	23	,	,	PUNCT
admet-557	137	24	1.12	1.12	NUM
admet-557	137	25	and	and	CCONJ
admet-557	137	26	1.43	1.43	NUM
admet-557	137	27	min	min	NOUN
admet-557	137	28	,	,	PUNCT
admet-557	137	29	respectively	respectively	ADV
admet-557	137	30	.	.	PUNCT
admet-557	138	1	the	the	DET
admet-557	138	2	total	total	ADJ
admet-557	138	3	run	run	NOUN
admet-557	138	4	time	time	NOUN
admet-557	138	5	is	be	AUX
admet-557	138	6	2.5	2.5	NUM
admet-557	138	7	min	min	NOUN
admet-557	138	8	(	(	PUNCT
admet-557	138	9	fig	fig	NOUN
admet-557	138	10	.	.	PUNCT
admet-557	139	1	2a	2a	NUM
admet-557	139	2	-	-	PUNCT
admet-557	139	3	d	d	NOUN
admet-557	139	4	)	)	PUNCT
admet-557	139	5	.	.	PUNCT
admet-557	140	1	method	method	NOUN
admet-557	140	2	validation	validation	NOUN
admet-557	140	3	selectivity	selectivity	NOUN
admet-557	140	4	as	as	SCONJ
admet-557	140	5	shown	show	VERB
admet-557	140	6	in	in	ADP
admet-557	140	7	figures	figure	NOUN
admet-557	140	8	2a	2a	NUM
admet-557	140	9	-	-	SYM
admet-557	140	10	d	d	NOUN
admet-557	140	11	no	no	DET
admet-557	140	12	significant	significant	ADJ
admet-557	140	13	interferences	interference	NOUN
admet-557	140	14	in	in	ADP
admet-557	140	15	the	the	DET
admet-557	140	16	blank	blank	ADJ
admet-557	140	17	dbs	dbs	PROPN
admet-557	140	18	traces	trace	NOUN
admet-557	140	19	were	be	AUX
admet-557	140	20	found	find	VERB
admet-557	140	21	from	from	ADP
admet-557	140	22	endogenous	endogenous	ADJ
admet-557	140	23	components	component	NOUN
admet-557	140	24	in	in	ADP
admet-557	140	25	drug	drug	NOUN
admet-557	140	26	-	-	PUNCT
admet-557	140	27	free	free	ADJ
admet-557	140	28	mice	mouse	NOUN
admet-557	140	29	blood	blood	NOUN
admet-557	140	30	at	at	ADP
admet-557	140	31	the	the	DET
admet-557	140	32	retention	retention	NOUN
admet-557	140	33	times	time	NOUN
admet-557	140	34	of	of	ADP
admet-557	140	35	the	the	DET
admet-557	140	36	enzalutamide	enzalutamide	ADJ
admet-557	140	37	,	,	PUNCT
admet-557	140	38	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	140	39	,	,	PUNCT
admet-557	140	40	darolutamide	darolutamide	NOUN
admet-557	140	41	,	,	PUNCT
admet-557	140	42	orm-15341	orm-15341	NOUN
admet-557	140	43	and	and	CCONJ
admet-557	140	44	the	the	PRON
admet-557	140	45	is	be	AUX
admet-557	140	46	indicating	indicate	VERB
admet-557	140	47	that	that	SCONJ
admet-557	140	48	the	the	DET
admet-557	140	49	method	method	NOUN
admet-557	140	50	is	be	AUX
admet-557	140	51	selective	selective	ADJ
admet-557	140	52	.	.	PUNCT
admet-557	141	1	sensitivity	sensitivity	NOUN
admet-557	141	2	the	the	DET
admet-557	141	3	lowest	low	ADJ
admet-557	141	4	limit	limit	NOUN
admet-557	141	5	of	of	ADP
admet-557	141	6	reliable	reliable	ADJ
admet-557	141	7	quantification	quantification	NOUN
admet-557	141	8	for	for	ADP
admet-557	141	9	the	the	DET
admet-557	141	10	analyte	analyte	NOUN
admet-557	141	11	was	be	AUX
admet-557	141	12	set	set	VERB
admet-557	141	13	at	at	ADP
admet-557	141	14	the	the	DET
admet-557	141	15	concentration	concentration	NOUN
admet-557	141	16	of	of	ADP
admet-557	141	17	the	the	DET
admet-557	141	18	lloq	lloq	NOUN
admet-557	141	19	.	.	PUNCT
admet-557	142	1	the	the	DET
admet-557	142	2	precision	precision	NOUN
admet-557	142	3	and	and	CCONJ
admet-557	142	4	accuracy	accuracy	NOUN
admet-557	142	5	at	at	ADP
admet-557	142	6	lloq	lloq	PROPN
admet-557	142	7	concentration	concentration	NOUN
admet-557	142	8	were	be	AUX
admet-557	142	9	found	find	VERB
admet-557	142	10	to	to	PART
admet-557	142	11	be	be	AUX
admet-557	142	12	7.00	7.00	NUM
admet-557	142	13	and	and	CCONJ
admet-557	142	14	103	103	NUM
admet-557	142	15	%	%	NOUN
admet-557	142	16	for	for	ADP
admet-557	142	17	enzalutamide	enzalutamide	NOUN
admet-557	142	18	;	;	PUNCT
admet-557	142	19	3.70	3.70	NUM
admet-557	142	20	and	and	CCONJ
admet-557	142	21	98.0	98.0	NUM
admet-557	142	22	%	%	NOUN
admet-557	142	23	for	for	ADP
admet-557	142	24	n	n	X
admet-557	142	25	-	-	PUNCT
admet-557	142	26	desmethylenzalutamide	desmethylenzalutamide	NOUN
admet-557	142	27	;	;	PUNCT
admet-557	142	28	5.25	5.25	NUM
admet-557	142	29	and	and	CCONJ
admet-557	142	30	95.2	95.2	NUM
admet-557	142	31	%	%	NOUN
admet-557	142	32	for	for	ADP
admet-557	142	33	darolutamide	darolutamide	NOUN
admet-557	142	34	and	and	CCONJ
admet-557	142	35	2.85	2.85	NUM
admet-557	142	36	and	and	CCONJ
admet-557	142	37	103	103	NUM
admet-557	142	38	%	%	NOUN
admet-557	142	39	for	for	ADP
admet-557	142	40	orm15341	orm15341	NOUN
admet-557	142	41	.	.	PUNCT
admet-557	143	1	there	there	PRON
admet-557	143	2	was	be	VERB
admet-557	143	3	no	no	DET
admet-557	143	4	carry	carry	NOUN
admet-557	143	5	-	-	PUNCT
admet-557	143	6	over	over	NOUN
admet-557	143	7	produced	produce	VERB
admet-557	143	8	by	by	ADP
admet-557	143	9	the	the	DET
admet-557	143	10	highest	high	ADJ
admet-557	143	11	calibration	calibration	NOUN
admet-557	143	12	sample	sample	NOUN
admet-557	143	13	on	on	ADP
admet-557	143	14	the	the	DET
admet-557	143	15	following	following	NOUN
admet-557	143	16	injected	inject	VERB
admet-557	143	17	blank	blank	ADJ
admet-557	143	18	dbs	dbs	PROPN
admet-557	143	19	extract	extract	NOUN
admet-557	143	20	sample	sample	NOUN
admet-557	143	21	.	.	PUNCT
admet-557	144	1	recovery	recovery	NOUN
admet-557	144	2	the	the	DET
admet-557	144	3	recovery	recovery	NOUN
admet-557	144	4	(	(	PUNCT
admet-557	144	5	mean	mean	PROPN
admet-557	144	6	±	±	NUM
admet-557	144	7	s.d	s.d	PROPN
admet-557	144	8	)	)	PUNCT
admet-557	144	9	for	for	ADP
admet-557	144	10	enzalutamide	enzalutamide	ADJ
admet-557	144	11	,	,	PUNCT
admet-557	144	12	n	n	CCONJ
admet-557	144	13	-	-	PUNCT
admet-557	144	14	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	144	15	,	,	PUNCT
admet-557	144	16	darolutamide	darolutamide	NOUN
admet-557	144	17	and	and	CCONJ
admet-557	144	18	orm-15341	orm-15341	NOUN
admet-557	144	19	(	(	PUNCT
admet-557	144	20	at	at	ADP
admet-557	144	21	lqc	lqc	PROPN
admet-557	144	22	,	,	PUNCT
admet-557	144	23	mqc	mqc	PROPN
admet-557	144	24	and	and	CCONJ
admet-557	144	25	hqc	hqc	PROPN
admet-557	144	26	)	)	PUNCT
admet-557	144	27	is	be	AUX
admet-557	144	28	presented	present	VERB
admet-557	144	29	in	in	ADP
admet-557	144	30	table	table	NOUN
admet-557	144	31	2	2	NUM
admet-557	144	32	.	.	PUNCT
admet-557	144	33	recovery	recovery	NOUN
admet-557	144	34	for	for	ADP
admet-557	144	35	the	the	PRON
admet-557	144	36	is	be	AUX
admet-557	144	37	was	be	AUX
admet-557	144	38	85.4	85.4	NUM
admet-557	144	39	±	±	NUM
admet-557	144	40	5.89	5.89	NUM
admet-557	144	41	%	%	NOUN
admet-557	144	42	.	.	PUNCT
admet-557	145	1	matrix	matrix	NOUN
admet-557	145	2	effect	effect	NOUN
admet-557	145	3	six	six	NUM
admet-557	145	4	different	different	ADJ
admet-557	145	5	lots	lot	NOUN
admet-557	145	6	of	of	ADP
admet-557	145	7	dbs	dbs	PROPN
admet-557	145	8	samples	sample	NOUN
admet-557	145	9	,	,	PUNCT
admet-557	145	10	spiked	spike	VERB
admet-557	145	11	with	with	ADP
admet-557	145	12	analytes	analyte	NOUN
admet-557	145	13	concentration	concentration	NOUN
admet-557	145	14	levels	level	NOUN
admet-557	145	15	at	at	ADP
admet-557	145	16	lqc	lqc	NOUN
admet-557	145	17	and	and	CCONJ
admet-557	145	18	hqc	hqc	PROPN
admet-557	145	19	levels	level	NOUN
admet-557	145	20	were	be	AUX
admet-557	145	21	analyzed	analyze	VERB
admet-557	145	22	.	.	PUNCT
admet-557	146	1	the	the	DET
admet-557	146	2	results	result	NOUN
admet-557	146	3	have	have	AUX
admet-557	146	4	shown	show	VERB
admet-557	146	5	that	that	SCONJ
admet-557	146	6	the	the	DET
admet-557	146	7	precision	precision	NOUN
admet-557	146	8	and	and	CCONJ
admet-557	146	9	accuracy	accuracy	NOUN
admet-557	146	10	for	for	ADP
admet-557	146	11	analyzed	analyze	VERB
admet-557	146	12	samples	sample	NOUN
admet-557	146	13	were	be	AUX
admet-557	146	14	within	within	ADP
admet-557	146	15	acceptance	acceptance	NOUN
admet-557	146	16	range	range	NOUN
admet-557	146	17	(	(	PUNCT
admet-557	146	18	table	table	NOUN
admet-557	146	19	2	2	NUM
admet-557	146	20	)	)	PUNCT
admet-557	146	21	.	.	PUNCT
admet-557	147	1	overall	overall	ADV
admet-557	147	2	it	it	PRON
admet-557	147	3	was	be	AUX
admet-557	147	4	found	find	VERB
admet-557	147	5	that	that	SCONJ
admet-557	147	6	there	there	PRON
admet-557	147	7	is	be	VERB
admet-557	147	8	no	no	DET
admet-557	147	9	impact	impact	NOUN
admet-557	147	10	on	on	ADP
admet-557	147	11	the	the	DET
admet-557	147	12	ionization	ionization	NOUN
admet-557	147	13	of	of	ADP
admet-557	147	14	analytes	analyte	NOUN
admet-557	147	15	and	and	CCONJ
admet-557	147	16	the	the	PRON
admet-557	147	17	is	be	AUX
admet-557	147	18	.	.	PUNCT
admet-557	147	19	matrix	matrix	NOUN
admet-557	147	20	effect	effect	NOUN
admet-557	147	21	for	for	ADP
admet-557	147	22	the	the	PRON
admet-557	147	23	is	be	AUX
admet-557	147	24	was	be	AUX
admet-557	147	25	105	105	NUM
admet-557	147	26	±	±	NUM
admet-557	147	27	1.25	1.25	NUM
admet-557	147	28	%	%	NOUN
admet-557	147	29	.	.	PUNCT
admet-557	148	1	admet	admet	PROPN
admet-557	148	2	&	&	CCONJ
admet-557	148	3	dmpk	dmpk	PROPN
admet-557	148	4	6(3	6(3	PROPN
admet-557	148	5	)	)	PUNCT
admet-557	148	6	(	(	PUNCT
admet-557	148	7	2018	2018	NUM
admet-557	148	8	)	)	PUNCT
admet-557	148	9	242	242	NUM
admet-557	148	10	-	-	SYM
admet-557	148	11	257	257	NUM
admet-557	148	12	lc	lc	PROPN
admet-557	148	13	-	-	PUNCT
admet-557	148	14	ms	ms	PROPN
admet-557	148	15	/	/	SYM
admet-557	148	16	ms	ms	NOUN
admet-557	148	17	determination	determination	NOUN
admet-557	148	18	of	of	ADP
admet-557	148	19	enzalutamide	enzalutamide	ADV
admet-557	148	20	/	/	SYM
admet-557	148	21	darolutamide	darolutamide	NOUN
admet-557	148	22	with	with	ADP
admet-557	148	23	metabolites	metabolite	NOUN
admet-557	148	24	on	on	ADP
admet-557	148	25	dbs	dbs	PROPN
admet-557	148	26	doi	doi	PROPN
admet-557	148	27	:	:	PUNCT
admet-557	148	28	10.5599	10.5599	NUM
admet-557	148	29	/	/	SYM
admet-557	148	30	admet.557	admet.557	PROPN
admet-557	148	31	249	249	NUM
admet-557	148	32	a	a	DET
admet-557	148	33	)	)	PUNCT
admet-557	148	34	b	b	NOUN
admet-557	148	35	)	)	PUNCT
admet-557	148	36	c	c	NOUN
admet-557	148	37	)	)	PUNCT
admet-557	148	38	d	d	NOUN
admet-557	148	39	)	)	PUNCT
admet-557	148	40	figure	figure	NOUN
admet-557	148	41	2.typical	2.typical	PROPN
admet-557	148	42	mrm	mrm	PROPN
admet-557	148	43	chromatograms	chromatograms	PROPN
admet-557	148	44	mice	mouse	NOUN
admet-557	148	45	blank	blank	ADJ
admet-557	148	46	dbs	dbs	PROPN
admet-557	148	47	(	(	PUNCT
admet-557	148	48	left	leave	VERB
admet-557	148	49	panel	panel	NOUN
admet-557	148	50	)	)	PUNCT
admet-557	148	51	,	,	PUNCT
admet-557	148	52	is	be	AUX
admet-557	148	53	(	(	PUNCT
admet-557	148	54	middle	middle	ADJ
admet-557	148	55	panel	panel	NOUN
admet-557	148	56	)	)	PUNCT
admet-557	148	57	and	and	CCONJ
admet-557	148	58	lloq	lloq	PROPN
admet-557	148	59	(	(	PUNCT
admet-557	148	60	right	right	ADJ
admet-557	148	61	panel	panel	NOUN
admet-557	148	62	)	)	PUNCT
admet-557	148	63	for	for	ADP
admet-557	148	64	(	(	PUNCT
admet-557	148	65	a	a	X
admet-557	148	66	)	)	PUNCT
admet-557	148	67	enzalutamide	enzalutamide	NOUN
admet-557	148	68	(	(	PUNCT
admet-557	148	69	b	b	NOUN
admet-557	148	70	)	)	PUNCT
admet-557	148	71	n	n	CCONJ
admet-557	148	72	-	-	PUNCT
admet-557	148	73	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	148	74	(	(	PUNCT
admet-557	148	75	c	c	NOUN
admet-557	148	76	)	)	PUNCT
admet-557	148	77	darolutamide	darolutamide	NOUN
admet-557	149	1	and	and	CCONJ
admet-557	149	2	(	(	PUNCT
admet-557	149	3	d	d	NOUN
admet-557	149	4	)	)	PUNCT
admet-557	149	5	orm-15341	orm-15341	PROPN
admet-557	149	6	r.	r.	PROPN
admet-557	149	7	mullangi	mullangi	PROPN
admet-557	149	8	et	et	PROPN
admet-557	149	9	al	al	PROPN
admet-557	149	10	.	.	PROPN
admet-557	149	11	admet	admet	PROPN
admet-557	149	12	&	&	CCONJ
admet-557	149	13	dmpk	dmpk	PROPN
admet-557	149	14	6(3	6(3	PROPN
admet-557	149	15	)	)	PUNCT
admet-557	149	16	(	(	PUNCT
admet-557	149	17	2018	2018	NUM
admet-557	149	18	)	)	PUNCT
admet-557	149	19	242	242	NUM
admet-557	149	20	-	-	SYM
admet-557	149	21	257	257	NUM
admet-557	149	22	250	250	NUM
admet-557	149	23	table	table	NOUN
admet-557	149	24	2	2	NUM
admet-557	149	25	.	.	PUNCT
admet-557	149	26	recovery	recovery	NOUN
admet-557	149	27	and	and	CCONJ
admet-557	149	28	matrix	matrix	NOUN
admet-557	149	29	data	datum	NOUN
admet-557	149	30	for	for	ADP
admet-557	149	31	enzalutamide	enzalutamide	NOUN
admet-557	149	32	,	,	PUNCT
admet-557	149	33	n	n	CCONJ
admet-557	149	34	-	-	PUNCT
admet-557	149	35	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	149	36	,	,	PUNCT
admet-557	149	37	darolutamide	darolutamide	NOUN
admet-557	149	38	and	and	CCONJ
admet-557	149	39	orm-15341	orm-15341	NOUN
admet-557	149	40	quality	quality	NOUN
admet-557	149	41	controls	control	NOUN
admet-557	149	42	on	on	ADP
admet-557	149	43	dbs	dbs	PROPN
admet-557	149	44	cards	card	NOUN
admet-557	149	45	mean	mean	VERB
admet-557	149	46	recovery	recovery	NOUN
admet-557	149	47	,	,	PUNCT
admet-557	149	48	%	%	NOUN
admet-557	149	49	mean	mean	NOUN
admet-557	149	50	±	±	NUM
admet-557	149	51	sd	sd	NOUN
admet-557	149	52	(	(	PUNCT
admet-557	149	53	n=4	n=4	NOUN
admet-557	149	54	)	)	PUNCT
admet-557	149	55	mean	mean	VERB
admet-557	149	56	absolute	absolute	ADJ
admet-557	149	57	matrix	matrix	NOUN
admet-557	149	58	effect	effect	NOUN
admet-557	149	59	,	,	PUNCT
admet-557	150	1	%	%	INTJ
admet-557	150	2	mean	mean	NOUN
admet-557	150	3	±	±	NUM
admet-557	150	4	sd	sd	NOUN
admet-557	150	5	(	(	PUNCT
admet-557	150	6	n=4	n=4	NOUN
admet-557	150	7	)	)	PUNCT
admet-557	150	8	lqc	lqc	NOUN
admet-557	150	9	(	(	PUNCT
admet-557	150	10	2.80	2.80	NUM
admet-557	150	11	ng	ng	PROPN
admet-557	150	12	/	/	SYM
admet-557	150	13	ml	ml	NOUN
admet-557	150	14	)	)	PUNCT
admet-557	150	15	enzalutamide	enzalutamide	ADV
admet-557	150	16	n	n	CCONJ
admet-557	150	17	-	-	PUNCT
admet-557	150	18	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	150	19	darolutamide	darolutamide	NOUN
admet-557	150	20	orm-15341	orm-15341	NOUN
admet-557	150	21	84.4	84.4	NUM
admet-557	150	22	±	±	NUM
admet-557	150	23	11.0	11.0	NUM
admet-557	150	24	78.0	78.0	NUM
admet-557	150	25	±	±	NUM
admet-557	150	26	7.83	7.83	NUM
admet-557	150	27	47.2	47.2	NUM
admet-557	150	28	±	±	NUM
admet-557	150	29	4.55	4.55	NUM
admet-557	150	30	79.7	79.7	NUM
admet-557	150	31	±	±	NUM
admet-557	150	32	15.4	15.4	NUM
admet-557	150	33	99.2	99.2	NUM
admet-557	150	34	±	±	NUM
admet-557	150	35	5.85	5.85	NUM
admet-557	150	36	101	101	NUM
admet-557	150	37	±	±	NUM
admet-557	150	38	8.58	8.58	NUM
admet-557	150	39	88.3	88.3	NUM
admet-557	150	40	±	±	NUM
admet-557	150	41	2.34	2.34	NUM
admet-557	150	42	95.8	95.8	NUM
admet-557	150	43	±	±	NUM
admet-557	150	44	6.23	6.23	NUM
admet-557	150	45	hqc	hqc	PROPN
admet-557	150	46	(	(	PUNCT
admet-557	150	47	1493	1493	NUM
admet-557	150	48	ng	ng	PROPN
admet-557	150	49	/	/	SYM
admet-557	150	50	ml	ml	NOUN
admet-557	150	51	)	)	PUNCT
admet-557	150	52	enzalutamide	enzalutamide	ADV
admet-557	150	53	n	n	CCONJ
admet-557	150	54	-	-	PUNCT
admet-557	150	55	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	150	56	darolutamide	darolutamide	NOUN
admet-557	150	57	orm-15341	orm-15341	NOUN
admet-557	150	58	78.6	78.6	NUM
admet-557	150	59	±	±	NUM
admet-557	150	60	4.50	4.50	NUM
admet-557	150	61	76.7	76.7	NUM
admet-557	150	62	±	±	NUM
admet-557	150	63	3.75	3.75	NUM
admet-557	150	64	50.3	50.3	NUM
admet-557	150	65	±	±	NUM
admet-557	150	66	1.99	1.99	NUM
admet-557	150	67	77.1	77.1	NUM
admet-557	150	68	±	±	NUM
admet-557	150	69	3.32	3.32	NUM
admet-557	150	70	95.3	95.3	NUM
admet-557	150	71	±	±	NUM
admet-557	150	72	12.0	12.0	NUM
admet-557	150	73	108	108	NUM
admet-557	150	74	±	±	NUM
admet-557	150	75	5.68	5.68	NUM
admet-557	150	76	85.2	85.2	NUM
admet-557	150	77	±	±	NUM
admet-557	150	78	1.35	1.35	NUM
admet-557	150	79	98.6	98.6	NUM
admet-557	150	80	±	±	NUM
admet-557	150	81	2.38	2.38	NUM
admet-557	150	82	sd	sd	NOUN
admet-557	150	83	:	:	PUNCT
admet-557	150	84	standard	standard	ADJ
admet-557	150	85	deviation	deviation	NOUN
admet-557	150	86	calibration	calibration	NOUN
admet-557	150	87	curve	curve	VERB
admet-557	150	88	the	the	DET
admet-557	150	89	blood	blood	NOUN
admet-557	150	90	calibration	calibration	NOUN
admet-557	150	91	curve	curve	NOUN
admet-557	150	92	was	be	AUX
admet-557	150	93	constructed	construct	VERB
admet-557	150	94	using	use	VERB
admet-557	150	95	eight	eight	NUM
admet-557	150	96	calibration	calibration	NOUN
admet-557	150	97	standards	standard	NOUN
admet-557	150	98	(	(	PUNCT
admet-557	150	99	viz	viz	PROPN
admet-557	150	100	.	.	PROPN
admet-557	150	101	,	,	PUNCT
admet-557	150	102	0.93	0.93	NUM
admet-557	150	103	-	-	SYM
admet-557	150	104	2000	2000	NUM
admet-557	150	105	ng	ng	PROPN
admet-557	150	106	/	/	SYM
admet-557	150	107	ml	ml	PROPN
admet-557	150	108	)	)	PUNCT
admet-557	150	109	.	.	PUNCT
admet-557	151	1	the	the	DET
admet-557	151	2	calibration	calibration	NOUN
admet-557	151	3	standard	standard	PROPN
admet-557	151	4	curve	curve	NOUN
admet-557	151	5	had	have	VERB
admet-557	151	6	a	a	DET
admet-557	151	7	reliable	reliable	ADJ
admet-557	151	8	reproducibility	reproducibility	NOUN
admet-557	151	9	over	over	ADP
admet-557	151	10	the	the	DET
admet-557	151	11	standard	standard	ADJ
admet-557	151	12	concentrations	concentration	NOUN
admet-557	151	13	across	across	ADP
admet-557	151	14	the	the	DET
admet-557	151	15	calibration	calibration	NOUN
admet-557	151	16	range	range	NOUN
admet-557	151	17	.	.	PUNCT
admet-557	152	1	calibration	calibration	NOUN
admet-557	152	2	curve	curve	NOUN
admet-557	152	3	was	be	AUX
admet-557	152	4	prepared	prepare	VERB
admet-557	152	5	by	by	ADP
admet-557	152	6	determining	determine	VERB
admet-557	152	7	the	the	DET
admet-557	152	8	best	good	ADJ
admet-557	152	9	fit	fit	NOUN
admet-557	152	10	of	of	ADP
admet-557	152	11	peak	peak	NOUN
admet-557	152	12	-	-	PUNCT
admet-557	152	13	area	area	NOUN
admet-557	152	14	ratios	ratio	NOUN
admet-557	152	15	(	(	PUNCT
admet-557	152	16	peak	peak	NOUN
admet-557	152	17	area	area	NOUN
admet-557	152	18	analyte	analyte	NOUN
admet-557	152	19	/	/	SYM
admet-557	152	20	peak	peak	NOUN
admet-557	152	21	area	area	NOUN
admet-557	152	22	is	be	AUX
admet-557	152	23	)	)	PUNCT
admet-557	152	24	versus	versus	ADP
admet-557	152	25	concentration	concentration	NOUN
admet-557	152	26	,	,	PUNCT
admet-557	152	27	and	and	CCONJ
admet-557	152	28	fitted	fit	VERB
admet-557	152	29	to	to	ADP
admet-557	152	30	the	the	DET
admet-557	152	31	y	y	PROPN
admet-557	152	32	=	=	SYM
admet-557	152	33	mx	mx	PROPN
admet-557	153	1	+	+	NOUN
admet-557	153	2	c	c	VERB
admet-557	153	3	using	use	VERB
admet-557	153	4	weighing	weighing	NOUN
admet-557	153	5	factor	factor	NOUN
admet-557	153	6	(	(	PUNCT
admet-557	153	7	1	1	NUM
admet-557	153	8	/	/	SYM
admet-557	153	9	x2	x2	NUM
admet-557	153	10	)	)	PUNCT
admet-557	153	11	.	.	PUNCT
admet-557	154	1	the	the	DET
admet-557	154	2	average	average	ADJ
admet-557	154	3	slope	slope	NOUN
admet-557	154	4	and	and	CCONJ
admet-557	154	5	intercept	intercept	NOUN
admet-557	154	6	values	value	NOUN
admet-557	154	7	were	be	AUX
admet-557	154	8	found	find	VERB
admet-557	154	9	to	to	PART
admet-557	154	10	be	be	AUX
admet-557	154	11	0.005358	0.005358	NOUN
admet-557	154	12	and	and	CCONJ
admet-557	154	13	0.002326	0.002326	NUM
admet-557	154	14	;	;	PUNCT
admet-557	154	15	0.005078	0.005078	NUM
admet-557	154	16	and	and	CCONJ
admet-557	154	17	-0.000221	-0.000221	NOUN
admet-557	154	18	;	;	PUNCT
admet-557	154	19	0.00682	0.00682	NUM
admet-557	154	20	and	and	CCONJ
admet-557	154	21	0.000485	0.000485	NUM
admet-557	154	22	;	;	PUNCT
admet-557	154	23	0.00967	0.00967	NUM
admet-557	154	24	and	and	CCONJ
admet-557	154	25	0.000272	0.000272	NUM
admet-557	154	26	for	for	ADP
admet-557	154	27	enzalutamide	enzalutamide	NOUN
admet-557	154	28	,	,	PUNCT
admet-557	154	29	n	n	CCONJ
admet-557	154	30	-	-	PUNCT
admet-557	154	31	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	154	32	,	,	PUNCT
admet-557	154	33	darolutamide	darolutamide	NOUN
admet-557	154	34	and	and	CCONJ
admet-557	154	35	orm-15341	orm-15341	NOUN
admet-557	154	36	,	,	PUNCT
admet-557	154	37	respectively	respectively	ADV
admet-557	154	38	.	.	PUNCT
admet-557	155	1	the	the	DET
admet-557	155	2	average	average	ADJ
admet-557	155	3	regression	regression	NOUN
admet-557	155	4	(	(	PUNCT
admet-557	155	5	n	n	NOUN
admet-557	155	6	=	=	SYM
admet-557	155	7	4	4	X
admet-557	155	8	)	)	PUNCT
admet-557	155	9	was	be	AUX
admet-557	155	10	found	find	VERB
admet-557	155	11	to	to	PART
admet-557	155	12	be	be	AUX
admet-557	155	13	>	>	X
admet-557	155	14	0.99	0.99	NUM
admet-557	155	15	for	for	ADP
admet-557	155	16	all	all	DET
admet-557	155	17	the	the	DET
admet-557	155	18	analytes	analyte	NOUN
admet-557	155	19	.	.	PUNCT
admet-557	156	1	the	the	DET
admet-557	156	2	lowest	low	ADJ
admet-557	156	3	concentration	concentration	NOUN
admet-557	156	4	with	with	ADP
admet-557	156	5	the	the	DET
admet-557	156	6	rsd	rsd	NOUN
admet-557	156	7	<	<	NOUN
admet-557	156	8	20	20	NUM
admet-557	156	9	%	%	NOUN
admet-557	156	10	was	be	AUX
admet-557	156	11	taken	take	VERB
admet-557	156	12	as	as	ADP
admet-557	156	13	lloq	lloq	NOUN
admet-557	156	14	and	and	CCONJ
admet-557	156	15	was	be	AUX
admet-557	156	16	found	find	VERB
admet-557	156	17	to	to	PART
admet-557	156	18	be	be	AUX
admet-557	156	19	0.93	0.93	NUM
admet-557	156	20	ng	ng	PROPN
admet-557	156	21	/	/	SYM
admet-557	156	22	ml	ml	PROPN
admet-557	156	23	.	.	PUNCT
admet-557	157	1	the	the	DET
admet-557	157	2	%	%	NOUN
admet-557	157	3	accuracy	accuracy	NOUN
admet-557	157	4	observed	observe	VERB
admet-557	157	5	for	for	ADP
admet-557	157	6	the	the	DET
admet-557	157	7	mean	mean	NOUN
admet-557	157	8	of	of	ADP
admet-557	157	9	back	back	ADV
admet-557	157	10	-	-	PUNCT
admet-557	157	11	calculated	calculate	VERB
admet-557	157	12	concentrations	concentration	NOUN
admet-557	157	13	for	for	ADP
admet-557	157	14	four	four	NUM
admet-557	157	15	calibration	calibration	NOUN
admet-557	157	16	curves	curve	NOUN
admet-557	157	17	was	be	AUX
admet-557	157	18	within	within	ADP
admet-557	157	19	86.8	86.8	NUM
admet-557	157	20	-	-	SYM
admet-557	157	21	114	114	NUM
admet-557	157	22	;	;	PUNCT
admet-557	157	23	85.0	85.0	NUM
admet-557	157	24	-	-	SYM
admet-557	157	25	108	108	NUM
admet-557	157	26	;	;	PUNCT
admet-557	157	27	87.1	87.1	NUM
admet-557	157	28	-	-	SYM
admet-557	157	29	110	110	NUM
admet-557	157	30	and	and	CCONJ
admet-557	157	31	90.9	90.9	NUM
admet-557	157	32	-	-	SYM
admet-557	157	33	103	103	NUM
admet-557	157	34	;	;	PUNCT
admet-557	157	35	while	while	SCONJ
admet-557	157	36	the	the	DET
admet-557	157	37	precision	precision	NOUN
admet-557	157	38	(	(	PUNCT
admet-557	157	39	%	%	INTJ
admet-557	157	40	cv	cv	NOUN
admet-557	157	41	)	)	PUNCT
admet-557	157	42	values	value	NOUN
admet-557	157	43	ranged	range	VERB
admet-557	157	44	from	from	ADP
admet-557	157	45	4.42	4.42	NUM
admet-557	157	46	-	-	SYM
admet-557	157	47	10.3	10.3	NUM
admet-557	157	48	;	;	PUNCT
admet-557	157	49	5.319.34	5.319.34	NUM
admet-557	157	50	;	;	PUNCT
admet-557	157	51	1.60	1.60	NUM
admet-557	157	52	-	-	SYM
admet-557	157	53	11.5	11.5	NUM
admet-557	157	54	and	and	CCONJ
admet-557	157	55	1.12	1.12	NUM
admet-557	157	56	-	-	NUM
admet-557	157	57	9.62	9.62	NUM
admet-557	157	58	for	for	ADP
admet-557	157	59	enzalutamide	enzalutamide	NOUN
admet-557	157	60	,	,	PUNCT
admet-557	157	61	n	n	CCONJ
admet-557	157	62	-	-	PUNCT
admet-557	157	63	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	157	64	,	,	PUNCT
admet-557	157	65	darolutamide	darolutamide	NOUN
admet-557	157	66	and	and	CCONJ
admet-557	157	67	orm-15341	orm-15341	NOUN
admet-557	157	68	,	,	PUNCT
admet-557	157	69	respectively	respectively	ADV
admet-557	157	70	.	.	PUNCT
admet-557	158	1	accuracy	accuracy	NOUN
admet-557	158	2	and	and	CCONJ
admet-557	158	3	precision	precision	NOUN
admet-557	158	4	accuracy	accuracy	NOUN
admet-557	158	5	and	and	CCONJ
admet-557	158	6	precision	precision	NOUN
admet-557	158	7	data	datum	NOUN
admet-557	158	8	for	for	ADP
admet-557	158	9	intraand	intraand	NOUN
admet-557	158	10	inter	inter	ADJ
admet-557	158	11	-	-	ADJ
admet-557	158	12	day	day	ADJ
admet-557	158	13	dbs	dbs	NOUN
admet-557	158	14	samples	sample	NOUN
admet-557	158	15	for	for	ADP
admet-557	158	16	enzalutamide	enzalutamide	ADJ
admet-557	158	17	,	,	PUNCT
admet-557	158	18	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	158	19	,	,	PUNCT
admet-557	158	20	darolutamide	darolutamide	NOUN
admet-557	158	21	and	and	CCONJ
admet-557	158	22	orm-15341	orm-15341	NOUN
admet-557	158	23	are	be	AUX
admet-557	158	24	presented	present	VERB
admet-557	158	25	in	in	ADP
admet-557	158	26	table	table	NOUN
admet-557	158	27	3	3	NUM
admet-557	158	28	.	.	PUNCT
admet-557	159	1	the	the	DET
admet-557	159	2	assay	assay	ADJ
admet-557	159	3	values	value	NOUN
admet-557	159	4	on	on	ADP
admet-557	159	5	both	both	CCONJ
admet-557	159	6	the	the	DET
admet-557	159	7	occasions	occasion	NOUN
admet-557	159	8	(	(	PUNCT
admet-557	159	9	intraand	intraand	X
admet-557	159	10	inter	inter	NOUN
admet-557	159	11	-	-	NOUN
admet-557	159	12	day	day	NOUN
admet-557	159	13	)	)	PUNCT
admet-557	159	14	were	be	AUX
admet-557	159	15	found	find	VERB
admet-557	159	16	to	to	PART
admet-557	159	17	be	be	AUX
admet-557	159	18	within	within	ADP
admet-557	159	19	the	the	DET
admet-557	159	20	accepted	accepted	ADJ
admet-557	159	21	variable	variable	ADJ
admet-557	159	22	limits	limit	NOUN
admet-557	159	23	.	.	PUNCT
admet-557	160	1	stability	stability	NOUN
admet-557	160	2	the	the	DET
admet-557	160	3	measured	measure	VERB
admet-557	160	4	concentrations	concentration	NOUN
admet-557	160	5	for	for	ADP
admet-557	160	6	enzalutamide	enzalutamide	NOUN
admet-557	160	7	,	,	PUNCT
admet-557	160	8	n	n	CCONJ
admet-557	160	9	-	-	PUNCT
admet-557	160	10	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	160	11	,	,	PUNCT
admet-557	160	12	darolutamide	darolutamide	NOUN
admet-557	160	13	and	and	CCONJ
admet-557	160	14	orm15341	orm15341	NOUN
admet-557	160	15	at	at	ADP
admet-557	160	16	2.80	2.80	NUM
admet-557	160	17	and	and	CCONJ
admet-557	160	18	1493	1493	NUM
admet-557	160	19	ng	ng	PROPN
admet-557	160	20	/	/	SYM
admet-557	160	21	ml	ml	NOUN
admet-557	160	22	were	be	AUX
admet-557	160	23	within	within	ADP
admet-557	160	24	85	85	NUM
admet-557	160	25	-	-	SYM
admet-557	160	26	115	115	NUM
admet-557	160	27	%	%	NOUN
admet-557	160	28	of	of	ADP
admet-557	160	29	re	re	NOUN
admet-557	160	30	and	and	CCONJ
admet-557	160	31	<	<	X
admet-557	160	32	15	15	NUM
admet-557	160	33	%	%	NOUN
admet-557	160	34	rsd	rsd	NOUN
admet-557	160	35	in	in	ADP
admet-557	160	36	a	a	DET
admet-557	160	37	battery	battery	NOUN
admet-557	160	38	of	of	ADP
admet-557	160	39	stability	stability	NOUN
admet-557	160	40	tests	test	NOUN
admet-557	160	41	viz	viz	VERB
admet-557	160	42	.	.	PUNCT
admet-557	160	43	,	,	PUNCT
admet-557	160	44	in	in	ADP
admet-557	160	45	-	-	PUNCT
admet-557	160	46	injector	injector	NOUN
admet-557	160	47	(	(	PUNCT
admet-557	160	48	24	24	NUM
admet-557	160	49	h	h	NOUN
admet-557	160	50	)	)	PUNCT
admet-557	160	51	,	,	PUNCT
admet-557	160	52	at	at	ADP
admet-557	160	53	room	room	NOUN
admet-557	160	54	temperature	temperature	NOUN
admet-557	160	55	for	for	ADP
admet-557	160	56	7	7	NUM
admet-557	160	57	days	day	NOUN
admet-557	160	58	,	,	PUNCT
admet-557	160	59	repeated	repeat	VERB
admet-557	160	60	three	three	NUM
admet-557	160	61	freeze	freeze	NOUN
admet-557	160	62	/	/	SYM
admet-557	160	63	thaw	thaw	NOUN
admet-557	160	64	cycles	cycle	NOUN
admet-557	160	65	and	and	CCONJ
admet-557	160	66	freezer	freezer	NOUN
admet-557	160	67	stability	stability	NOUN
admet-557	160	68	at	at	ADP
admet-557	160	69	-80	-80	PUNCT
admet-557	160	70	±	±	NUM
admet-557	160	71	10	10	NUM
admet-557	160	72	°	°	ADP
admet-557	160	73	c	c	NOUN
admet-557	160	74	for	for	ADP
admet-557	160	75	at	at	ADV
admet-557	160	76	least	least	ADJ
admet-557	160	77	for	for	ADP
admet-557	160	78	30	30	NUM
admet-557	160	79	days	day	NOUN
admet-557	160	80	(	(	PUNCT
admet-557	160	81	table	table	NOUN
admet-557	160	82	4	4	NUM
admet-557	160	83	)	)	PUNCT
admet-557	160	84	.	.	PUNCT
admet-557	161	1	dilution	dilution	NOUN
admet-557	161	2	effect	effect	NOUN
admet-557	161	3	the	the	DET
admet-557	161	4	accuracy	accuracy	NOUN
admet-557	161	5	of	of	ADP
admet-557	161	6	the	the	DET
admet-557	161	7	nominal	nominal	ADJ
admet-557	161	8	concentration	concentration	NOUN
admet-557	161	9	of	of	ADP
admet-557	161	10	the	the	DET
admet-557	161	11	diluted	dilute	VERB
admet-557	161	12	dbs	dbs	NOUN
admet-557	161	13	samples	sample	NOUN
admet-557	161	14	were	be	AUX
admet-557	161	15	within	within	ADP
admet-557	161	16	5.28	5.28	NUM
admet-557	161	17	%	%	NOUN
admet-557	161	18	and	and	CCONJ
admet-557	161	19	the	the	DET
admet-557	161	20	precision	precision	NOUN
admet-557	161	21	was	be	AUX
admet-557	161	22	8.56	8.56	NUM
admet-557	161	23	%	%	NOUN
admet-557	161	24	for	for	ADP
admet-557	161	25	all	all	DET
admet-557	161	26	the	the	DET
admet-557	161	27	analytes	analyte	NOUN
admet-557	161	28	,	,	PUNCT
admet-557	161	29	which	which	PRON
admet-557	161	30	show	show	VERB
admet-557	161	31	the	the	DET
admet-557	161	32	ability	ability	NOUN
admet-557	161	33	to	to	PART
admet-557	161	34	dilute	dilute	VERB
admet-557	161	35	samples	sample	NOUN
admet-557	161	36	up	up	ADP
admet-557	161	37	to	to	ADP
admet-557	161	38	a	a	DET
admet-557	161	39	dilution	dilution	NOUN
admet-557	161	40	factor	factor	NOUN
admet-557	161	41	of	of	ADP
admet-557	161	42	ten	ten	NUM
admet-557	161	43	in	in	ADP
admet-557	161	44	a	a	DET
admet-557	161	45	linear	linear	ADJ
admet-557	161	46	fashion	fashion	NOUN
admet-557	161	47	.	.	PUNCT
admet-557	162	1	admet	admet	PROPN
admet-557	162	2	&	&	CCONJ
admet-557	162	3	dmpk	dmpk	PROPN
admet-557	162	4	6(3	6(3	PROPN
admet-557	162	5	)	)	PUNCT
admet-557	162	6	(	(	PUNCT
admet-557	162	7	2018	2018	NUM
admet-557	162	8	)	)	PUNCT
admet-557	162	9	242	242	NUM
admet-557	162	10	-	-	SYM
admet-557	162	11	257	257	NUM
admet-557	162	12	lc	lc	PROPN
admet-557	162	13	-	-	PUNCT
admet-557	162	14	ms	ms	PROPN
admet-557	162	15	/	/	SYM
admet-557	162	16	ms	ms	NOUN
admet-557	162	17	determination	determination	NOUN
admet-557	162	18	of	of	ADP
admet-557	162	19	enzalutamide	enzalutamide	ADV
admet-557	162	20	/	/	SYM
admet-557	162	21	darolutamide	darolutamide	NOUN
admet-557	162	22	with	with	ADP
admet-557	162	23	metabolites	metabolite	NOUN
admet-557	162	24	on	on	ADP
admet-557	162	25	dbs	dbs	PROPN
admet-557	162	26	doi	doi	PROPN
admet-557	162	27	:	:	PUNCT
admet-557	162	28	10.5599	10.5599	NUM
admet-557	162	29	/	/	SYM
admet-557	162	30	admet.557	admet.557	PROPN
admet-557	162	31	251	251	NUM
admet-557	162	32	table	table	NOUN
admet-557	162	33	3	3	NUM
admet-557	162	34	.	.	PUNCT
admet-557	163	1	intraand	intraand	PROPN
admet-557	163	2	inter	inter	ADJ
admet-557	163	3	-	-	ADJ
admet-557	163	4	day	day	ADJ
admet-557	163	5	precision	precision	NOUN
admet-557	163	6	and	and	CCONJ
admet-557	163	7	accuracy	accuracy	NOUN
admet-557	163	8	determination	determination	NOUN
admet-557	163	9	for	for	ADP
admet-557	163	10	determination	determination	NOUN
admet-557	163	11	of	of	ADP
admet-557	163	12	enzalutamide	enzalutamide	ADJ
admet-557	163	13	,	,	PUNCT
admet-557	163	14	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	163	15	,	,	PUNCT
admet-557	163	16	darolutamide	darolutamide	NOUN
admet-557	163	17	and	and	CCONJ
admet-557	163	18	orm-15341	orm-15341	NOUN
admet-557	163	19	quality	quality	NOUN
admet-557	163	20	controls	control	NOUN
admet-557	163	21	on	on	ADP
admet-557	163	22	dbs	dbs	PROPN
admet-557	163	23	cards	card	NOUN
admet-557	163	24	parameters	parameter	NOUN
admet-557	163	25	enzalutamide	enzalutamide	ADV
admet-557	163	26	n	n	ADV
admet-557	163	27	-	-	PUNCT
admet-557	163	28	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	163	29	darolutamide	darolutamide	PROPN
admet-557	163	30	orm-15341	orm-15341	NOUN
admet-557	163	31	intra	intra	PROPN
admet-557	163	32	-	-	ADJ
admet-557	163	33	day	day	ADJ
admet-557	163	34	lloq	lloq	PROPN
admet-557	163	35	qc	qc	PROPN
admet-557	163	36	(	(	PUNCT
admet-557	163	37	0.93	0.93	NUM
admet-557	163	38	ng	ng	PROPN
admet-557	163	39	/	/	SYM
admet-557	163	40	ml	ml	NOUN
admet-557	163	41	)	)	PUNCT
admet-557	163	42	precision	precision	NOUN
admet-557	163	43	(	(	PUNCT
admet-557	163	44	%	%	NOUN
admet-557	163	45	rsd	rsd	NOUN
admet-557	163	46	)	)	PUNCT
admet-557	163	47	6.09	6.09	NUM
admet-557	163	48	2.08	2.08	NUM
admet-557	163	49	9.36	9.36	NUM
admet-557	163	50	2.68	2.68	NUM
admet-557	163	51	accuracy	accuracy	NOUN
admet-557	163	52	(	(	PUNCT
admet-557	163	53	%	%	INTJ
admet-557	163	54	re	re	NOUN
admet-557	163	55	)	)	PUNCT
admet-557	163	56	0.97	0.97	NUM
admet-557	163	57	0.92	0.92	NUM
admet-557	163	58	1.02	1.02	NUM
admet-557	163	59	0.96	0.96	NUM
admet-557	163	60	lqc	lqc	NOUN
admet-557	163	61	(	(	PUNCT
admet-557	163	62	2.80	2.80	NUM
admet-557	163	63	ng	ng	PROPN
admet-557	163	64	/	/	SYM
admet-557	163	65	ml	ml	NOUN
admet-557	163	66	)	)	PUNCT
admet-557	163	67	precision	precision	NOUN
admet-557	163	68	(	(	PUNCT
admet-557	163	69	%	%	NOUN
admet-557	163	70	rsd	rsd	NOUN
admet-557	163	71	)	)	PUNCT
admet-557	163	72	3.24	3.24	NUM
admet-557	163	73	0.18	0.18	NUM
admet-557	163	74	10.2	10.2	NUM
admet-557	163	75	11.7	11.7	NUM
admet-557	163	76	accuracy	accuracy	NOUN
admet-557	163	77	(	(	PUNCT
admet-557	163	78	%	%	INTJ
admet-557	163	79	re	re	NOUN
admet-557	163	80	)	)	PUNCT
admet-557	163	81	0.90	0.90	NUM
admet-557	163	82	0.96	0.96	NUM
admet-557	163	83	1.09	1.09	NUM
admet-557	163	84	0.96	0.96	NUM
admet-557	163	85	mqc	mqc	NOUN
admet-557	163	86	(	(	PUNCT
admet-557	163	87	853	853	NUM
admet-557	163	88	ng	ng	PROPN
admet-557	163	89	/	/	SYM
admet-557	163	90	ml	ml	NOUN
admet-557	163	91	)	)	PUNCT
admet-557	163	92	precision	precision	NOUN
admet-557	163	93	(	(	PUNCT
admet-557	163	94	%	%	NOUN
admet-557	163	95	rsd	rsd	NOUN
admet-557	163	96	)	)	PUNCT
admet-557	163	97	6.53	6.53	NUM
admet-557	163	98	3.45	3.45	NUM
admet-557	163	99	5.17	5.17	NUM
admet-557	163	100	4.73	4.73	NUM
admet-557	163	101	accuracy	accuracy	NOUN
admet-557	163	102	(	(	PUNCT
admet-557	163	103	%	%	INTJ
admet-557	163	104	re	re	NOUN
admet-557	163	105	)	)	PUNCT
admet-557	163	106	1.04	1.04	NUM
admet-557	163	107	1.11	1.11	NUM
admet-557	163	108	0.97	0.97	NUM
admet-557	163	109	1.14	1.14	NUM
admet-557	163	110	hqc	hqc	PROPN
admet-557	163	111	(	(	PUNCT
admet-557	163	112	1493	1493	NUM
admet-557	163	113	ng	ng	PROPN
admet-557	163	114	/	/	SYM
admet-557	163	115	ml	ml	NOUN
admet-557	163	116	)	)	PUNCT
admet-557	163	117	precision	precision	NOUN
admet-557	163	118	(	(	PUNCT
admet-557	163	119	%	%	NOUN
admet-557	163	120	rsd	rsd	NOUN
admet-557	163	121	)	)	PUNCT
admet-557	163	122	0.90	0.90	NUM
admet-557	163	123	3.92	3.92	NUM
admet-557	163	124	5.26	5.26	NUM
admet-557	163	125	12.0	12.0	NUM
admet-557	163	126	accuracy	accuracy	NOUN
admet-557	163	127	(	(	PUNCT
admet-557	163	128	%	%	INTJ
admet-557	163	129	re	re	NOUN
admet-557	163	130	)	)	PUNCT
admet-557	163	131	0.99	0.99	NUM
admet-557	163	132	1.00	1.00	NUM
admet-557	163	133	0.86	0.86	NUM
admet-557	163	134	1.13	1.13	NUM
admet-557	163	135	inter	inter	ADJ
admet-557	163	136	-	-	ADJ
admet-557	163	137	day	day	ADJ
admet-557	163	138	lloq	lloq	PROPN
admet-557	163	139	qc	qc	PROPN
admet-557	163	140	(	(	PUNCT
admet-557	163	141	0.93	0.93	NUM
admet-557	163	142	ng	ng	PROPN
admet-557	163	143	/	/	SYM
admet-557	163	144	ml	ml	NOUN
admet-557	163	145	)	)	PUNCT
admet-557	163	146	precision	precision	NOUN
admet-557	163	147	(	(	PUNCT
admet-557	163	148	%	%	NOUN
admet-557	163	149	rsd	rsd	NOUN
admet-557	163	150	)	)	PUNCT
admet-557	163	151	8.01	8.01	NUM
admet-557	163	152	5.01	5.01	NUM
admet-557	163	153	6.54	6.54	NUM
admet-557	163	154	1.02	1.02	NUM
admet-557	163	155	accuracy	accuracy	NOUN
admet-557	163	156	(	(	PUNCT
admet-557	163	157	%	%	INTJ
admet-557	163	158	re	re	NOUN
admet-557	163	159	)	)	PUNCT
admet-557	163	160	1.00	1.00	NUM
admet-557	163	161	1.07	1.07	NUM
admet-557	163	162	1.05	1.05	NUM
admet-557	163	163	1.06	1.06	NUM
admet-557	163	164	lqc	lqc	NOUN
admet-557	163	165	(	(	PUNCT
admet-557	163	166	2.80	2.80	NUM
admet-557	163	167	ng	ng	PROPN
admet-557	163	168	/	/	SYM
admet-557	163	169	ml	ml	NOUN
admet-557	163	170	)	)	PUNCT
admet-557	163	171	precision	precision	NOUN
admet-557	163	172	(	(	PUNCT
admet-557	163	173	%	%	NOUN
admet-557	163	174	rsd	rsd	NOUN
admet-557	163	175	)	)	PUNCT
admet-557	163	176	7.54	7.54	NUM
admet-557	163	177	3.29	3.29	NUM
admet-557	163	178	10.8	10.8	NUM
admet-557	163	179	5.25	5.25	NUM
admet-557	163	180	accuracy	accuracy	NOUN
admet-557	163	181	(	(	PUNCT
admet-557	163	182	%	%	INTJ
admet-557	163	183	re	re	NOUN
admet-557	163	184	)	)	PUNCT
admet-557	163	185	0.96	0.96	NUM
admet-557	163	186	1.04	1.04	NUM
admet-557	163	187	0.96	0.96	NUM
admet-557	163	188	1.02	1.02	NUM
admet-557	163	189	mqc	mqc	NOUN
admet-557	163	190	(	(	PUNCT
admet-557	163	191	853	853	NUM
admet-557	163	192	ng	ng	PROPN
admet-557	163	193	/	/	SYM
admet-557	163	194	ml	ml	NOUN
admet-557	163	195	)	)	PUNCT
admet-557	163	196	precision	precision	NOUN
admet-557	163	197	(	(	PUNCT
admet-557	163	198	%	%	NOUN
admet-557	163	199	rsd	rsd	NOUN
admet-557	163	200	)	)	PUNCT
admet-557	163	201	2.38	2.38	NUM
admet-557	163	202	2.73	2.73	NUM
admet-557	163	203	8.58	8.58	NUM
admet-557	163	204	10.8	10.8	NUM
admet-557	163	205	accuracy	accuracy	NOUN
admet-557	163	206	(	(	PUNCT
admet-557	163	207	%	%	INTJ
admet-557	163	208	re	re	NOUN
admet-557	163	209	)	)	PUNCT
admet-557	163	210	1.02	1.02	NUM
admet-557	163	211	1.12	1.12	NUM
admet-557	163	212	1.12	1.12	NUM
admet-557	163	213	1.14	1.14	NUM
admet-557	163	214	hqc	hqc	PROPN
admet-557	163	215	(	(	PUNCT
admet-557	163	216	1493	1493	NUM
admet-557	163	217	ng	ng	PROPN
admet-557	163	218	/	/	SYM
admet-557	163	219	ml	ml	NOUN
admet-557	163	220	)	)	PUNCT
admet-557	163	221	precision	precision	NOUN
admet-557	163	222	(	(	PUNCT
admet-557	163	223	%	%	NOUN
admet-557	163	224	rsd	rsd	NOUN
admet-557	163	225	)	)	PUNCT
admet-557	163	226	2.18	2.18	NUM
admet-557	163	227	1.58	1.58	NUM
admet-557	163	228	11.2	11.2	NUM
admet-557	163	229	9.28	9.28	NUM
admet-557	163	230	accuracy	accuracy	NOUN
admet-557	163	231	(	(	PUNCT
admet-557	163	232	%	%	INTJ
admet-557	163	233	re	re	NOUN
admet-557	163	234	)	)	PUNCT
admet-557	163	235	1.04	1.04	NUM
admet-557	163	236	0.99	0.99	NUM
admet-557	163	237	1.00	1.00	NUM
admet-557	163	238	1.14	1.14	NUM
admet-557	163	239	%	%	NOUN
admet-557	163	240	rsd	rsd	NOUN
admet-557	163	241	:	:	PUNCT
admet-557	163	242	relative	relative	ADJ
admet-557	163	243	standard	standard	ADJ
admet-557	163	244	deviation	deviation	NOUN
admet-557	163	245	(	(	PUNCT
admet-557	163	246	sd	sd	NOUN
admet-557	163	247	x	x	SYM
admet-557	163	248	100	100	NUM
admet-557	163	249	/	/	SYM
admet-557	163	250	mean	mean	NOUN
admet-557	163	251	)	)	PUNCT
admet-557	163	252	%	%	NOUN
admet-557	163	253	re	re	ADP
admet-557	163	254	:	:	PUNCT
admet-557	163	255	relative	relative	ADJ
admet-557	163	256	error	error	NOUN
admet-557	163	257	(	(	PUNCT
admet-557	163	258	measured	measure	VERB
admet-557	163	259	value	value	NOUN
admet-557	163	260	/	/	SYM
admet-557	163	261	actual	actual	ADJ
admet-557	163	262	value	value	NOUN
admet-557	163	263	)	)	PUNCT
admet-557	163	264	hematocrit	hematocrit	PROPN
admet-557	163	265	effect	effect	NOUN
admet-557	163	266	the	the	DET
admet-557	163	267	measured	measured	ADJ
admet-557	163	268	enzalutamide	enzalutamide	NOUN
admet-557	163	269	,	,	PUNCT
admet-557	163	270	n	n	CCONJ
admet-557	163	271	-	-	PUNCT
admet-557	163	272	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	163	273	,	,	PUNCT
admet-557	163	274	darolutamide	darolutamide	NOUN
admet-557	163	275	and	and	CCONJ
admet-557	163	276	orm-15341	orm-15341	NOUN
admet-557	163	277	concentrations	concentration	NOUN
admet-557	163	278	were	be	AUX
admet-557	163	279	compared	compare	VERB
admet-557	163	280	with	with	ADP
admet-557	163	281	the	the	DET
admet-557	163	282	results	result	NOUN
admet-557	163	283	obtained	obtain	VERB
admet-557	163	284	from	from	ADP
admet-557	163	285	dbs	dbs	PROPN
admet-557	163	286	samples	sample	NOUN
admet-557	163	287	are	be	AUX
admet-557	163	288	given	give	VERB
admet-557	163	289	in	in	ADP
admet-557	163	290	table	table	NOUN
admet-557	163	291	5	5	NUM
admet-557	163	292	.	.	PUNCT
admet-557	164	1	the	the	DET
admet-557	164	2	%	%	NOUN
admet-557	164	3	difference	difference	NOUN
admet-557	164	4	was	be	AUX
admet-557	164	5	calculated	calculate	VERB
admet-557	164	6	by	by	ADP
admet-557	164	7	subtracting	subtract	VERB
admet-557	164	8	the	the	DET
admet-557	164	9	%	%	NOUN
admet-557	164	10	relative	relative	ADJ
admet-557	164	11	error	error	NOUN
admet-557	164	12	of	of	ADP
admet-557	164	13	hct	hct	PROPN
admet-557	164	14	25	25	NUM
admet-557	164	15	and	and	CCONJ
admet-557	164	16	45	45	NUM
admet-557	164	17	%	%	NOUN
admet-557	164	18	from	from	ADP
admet-557	164	19	%	%	NOUN
admet-557	164	20	relative	relative	ADJ
admet-557	164	21	error	error	NOUN
admet-557	164	22	of	of	ADP
admet-557	164	23	40	40	NUM
admet-557	164	24	%	%	NOUN
admet-557	164	25	hct	hct	NOUN
admet-557	164	26	which	which	PRON
admet-557	164	27	was	be	AUX
admet-557	164	28	taken	take	VERB
admet-557	164	29	as	as	ADP
admet-557	164	30	standard	standard	ADJ
admet-557	164	31	hct	hct	NOUN
admet-557	164	32	value	value	NOUN
admet-557	164	33	.	.	PUNCT
admet-557	165	1	no	no	DET
admet-557	165	2	significant	significant	ADJ
admet-557	165	3	impact	impact	NOUN
admet-557	165	4	of	of	ADP
admet-557	165	5	hct	hct	NOUN
admet-557	165	6	on	on	ADP
admet-557	165	7	accuracy	accuracy	NOUN
admet-557	165	8	was	be	AUX
admet-557	165	9	observed	observe	VERB
admet-557	165	10	for	for	ADP
admet-557	165	11	all	all	DET
admet-557	165	12	the	the	DET
admet-557	165	13	analytes	analyte	NOUN
admet-557	165	14	.	.	PUNCT
admet-557	166	1	r.	r.	PROPN
admet-557	166	2	mullangi	mullangi	VERB
admet-557	166	3	et	et	PROPN
admet-557	166	4	al	al	PROPN
admet-557	166	5	.	.	PROPN
admet-557	166	6	admet	admet	PROPN
admet-557	166	7	&	&	CCONJ
admet-557	166	8	dmpk	dmpk	PROPN
admet-557	166	9	6(3	6(3	PROPN
admet-557	166	10	)	)	PUNCT
admet-557	166	11	(	(	PUNCT
admet-557	166	12	2018	2018	NUM
admet-557	166	13	)	)	PUNCT
admet-557	166	14	242	242	NUM
admet-557	166	15	-	-	SYM
admet-557	166	16	257	257	NUM
admet-557	166	17	252	252	NUM
admet-557	166	18	table	table	NOUN
admet-557	166	19	4	4	NUM
admet-557	166	20	.	.	PUNCT
admet-557	167	1	stability	stability	NOUN
admet-557	167	2	data	datum	NOUN
admet-557	167	3	of	of	ADP
admet-557	167	4	enzalutamide	enzalutamide	NOUN
admet-557	167	5	,	,	PUNCT
admet-557	167	6	n	n	CCONJ
admet-557	167	7	-	-	PUNCT
admet-557	167	8	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	167	9	,	,	PUNCT
admet-557	167	10	darolutamide	darolutamide	NOUN
admet-557	167	11	and	and	CCONJ
admet-557	167	12	orm-15341	orm-15341	NOUN
admet-557	167	13	quality	quality	NOUN
admet-557	167	14	controls	control	NOUN
admet-557	167	15	on	on	ADP
admet-557	167	16	dbs	dbs	PROPN
admet-557	167	17	cards	card	NOUN
admet-557	167	18	parameters	parameter	NOUN
admet-557	167	19	enzalutamide	enzalutamide	ADV
admet-557	167	20	n	n	ADV
admet-557	167	21	-	-	PUNCT
admet-557	167	22	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	167	23	darolutamide	darolutamide	NOUN
admet-557	167	24	orm15341	orm15341	NOUN
admet-557	167	25	room	room	NOUN
admet-557	167	26	temperature	temperature	NOUN
admet-557	167	27	(	(	PUNCT
admet-557	167	28	7	7	NUM
admet-557	167	29	days	day	NOUN
admet-557	167	30	)	)	PUNCT
admet-557	167	31	lqc	lqc	NOUN
admet-557	167	32	(	(	PUNCT
admet-557	167	33	2.80	2.80	NUM
admet-557	167	34	ng	ng	PROPN
admet-557	167	35	/	/	SYM
admet-557	167	36	ml	ml	NOUN
admet-557	167	37	)	)	PUNCT
admet-557	167	38	precision	precision	NOUN
admet-557	167	39	(	(	PUNCT
admet-557	167	40	%	%	NOUN
admet-557	167	41	rsd	rsd	NOUN
admet-557	167	42	)	)	PUNCT
admet-557	167	43	2.58	2.58	NUM
admet-557	167	44	7.58	7.58	NUM
admet-557	167	45	5.98	5.98	NUM
admet-557	167	46	7.68	7.68	NUM
admet-557	167	47	accuracy	accuracy	NOUN
admet-557	167	48	(	(	PUNCT
admet-557	167	49	%	%	INTJ
admet-557	167	50	re	re	NOUN
admet-557	167	51	)	)	PUNCT
admet-557	167	52	0.91	0.91	NUM
admet-557	167	53	0.86	0.86	NUM
admet-557	167	54	0.95	0.95	NUM
admet-557	167	55	0.98	0.98	NUM
admet-557	167	56	hqc	hqc	PROPN
admet-557	167	57	(	(	PUNCT
admet-557	167	58	1493	1493	NUM
admet-557	167	59	ng	ng	PROPN
admet-557	167	60	/	/	SYM
admet-557	167	61	ml	ml	NOUN
admet-557	167	62	)	)	PUNCT
admet-557	167	63	precision	precision	NOUN
admet-557	167	64	(	(	PUNCT
admet-557	167	65	%	%	NOUN
admet-557	167	66	rsd	rsd	NOUN
admet-557	167	67	)	)	PUNCT
admet-557	167	68	5.84	5.84	NUM
admet-557	167	69	5.68	5.68	NUM
admet-557	167	70	3.56	3.56	NUM
admet-557	167	71	4.89	4.89	NUM
admet-557	167	72	accuracy	accuracy	NOUN
admet-557	167	73	(	(	PUNCT
admet-557	167	74	%	%	INTJ
admet-557	167	75	re	re	NOUN
admet-557	167	76	)	)	PUNCT
admet-557	167	77	1.02	1.02	NUM
admet-557	167	78	0.95	0.95	NUM
admet-557	167	79	0.98	0.98	NUM
admet-557	167	80	0.86	0.86	NUM
admet-557	167	81	in	in	ADP
admet-557	167	82	-	-	PUNCT
admet-557	167	83	injector	injector	NOUN
admet-557	167	84	(	(	PUNCT
admet-557	167	85	24	24	NUM
admet-557	167	86	h	h	NOUN
admet-557	167	87	)	)	PUNCT
admet-557	167	88	lqc	lqc	NOUN
admet-557	167	89	(	(	PUNCT
admet-557	167	90	2.80	2.80	NUM
admet-557	167	91	ng	ng	PROPN
admet-557	167	92	/	/	SYM
admet-557	167	93	ml	ml	NOUN
admet-557	167	94	)	)	PUNCT
admet-557	167	95	precision	precision	NOUN
admet-557	167	96	(	(	PUNCT
admet-557	167	97	%	%	NOUN
admet-557	167	98	rsd	rsd	NOUN
admet-557	167	99	)	)	PUNCT
admet-557	167	100	6.78	6.78	NUM
admet-557	167	101	0.73	0.73	NUM
admet-557	167	102	7.04	7.04	NUM
admet-557	167	103	4.60	4.60	NUM
admet-557	167	104	accuracy	accuracy	NOUN
admet-557	167	105	(	(	PUNCT
admet-557	167	106	%	%	INTJ
admet-557	167	107	re	re	NOUN
admet-557	167	108	)	)	PUNCT
admet-557	167	109	0.87	0.87	NUM
admet-557	167	110	0.85	0.85	NUM
admet-557	167	111	0.90	0.90	NUM
admet-557	167	112	0.94	0.94	NUM
admet-557	167	113	hqc	hqc	PROPN
admet-557	167	114	(	(	PUNCT
admet-557	167	115	1493	1493	NUM
admet-557	167	116	ng	ng	PROPN
admet-557	167	117	/	/	SYM
admet-557	167	118	ml	ml	NOUN
admet-557	167	119	)	)	PUNCT
admet-557	167	120	precision	precision	NOUN
admet-557	167	121	(	(	PUNCT
admet-557	167	122	%	%	NOUN
admet-557	167	123	rsd	rsd	NOUN
admet-557	167	124	)	)	PUNCT
admet-557	167	125	8.58	8.58	NUM
admet-557	167	126	10.3	10.3	NUM
admet-557	167	127	9.08	9.08	NUM
admet-557	167	128	11.0	11.0	NUM
admet-557	167	129	accuracy	accuracy	NOUN
admet-557	167	130	(	(	PUNCT
admet-557	167	131	%	%	INTJ
admet-557	167	132	re	re	NOUN
admet-557	167	133	)	)	PUNCT
admet-557	167	134	0.95	0.95	NUM
admet-557	167	135	0.86	0.86	NUM
admet-557	167	136	1.00	1.00	NUM
admet-557	167	137	0.87	0.87	NUM
admet-557	167	138	3	3	NUM
admet-557	167	139	f	f	PROPN
admet-557	167	140	/	/	SYM
admet-557	167	141	t	t	PROPN
admet-557	167	142	cycle	cycle	NOUN
admet-557	167	143	lqc	lqc	NOUN
admet-557	167	144	(	(	PUNCT
admet-557	167	145	2.80	2.80	NUM
admet-557	167	146	ng	ng	PROPN
admet-557	167	147	/	/	SYM
admet-557	167	148	ml	ml	NOUN
admet-557	167	149	)	)	PUNCT
admet-557	167	150	precision	precision	NOUN
admet-557	167	151	(	(	PUNCT
admet-557	167	152	%	%	NOUN
admet-557	167	153	rsd	rsd	NOUN
admet-557	167	154	)	)	PUNCT
admet-557	167	155	5.03	5.03	NUM
admet-557	167	156	6.60	6.60	NUM
admet-557	167	157	8.65	8.65	NUM
admet-557	167	158	5.68	5.68	NUM
admet-557	167	159	accuracy	accuracy	NOUN
admet-557	167	160	(	(	PUNCT
admet-557	167	161	%	%	INTJ
admet-557	167	162	re	re	NOUN
admet-557	167	163	)	)	PUNCT
admet-557	167	164	1.10	1.10	NUM
admet-557	167	165	0.99	0.99	NUM
admet-557	167	166	0.95	0.95	NUM
admet-557	167	167	0.88	0.88	NUM
admet-557	167	168	hqc	hqc	PROPN
admet-557	167	169	(	(	PUNCT
admet-557	167	170	1493	1493	NUM
admet-557	167	171	ng	ng	PROPN
admet-557	167	172	/	/	SYM
admet-557	167	173	ml	ml	NOUN
admet-557	167	174	)	)	PUNCT
admet-557	167	175	precision	precision	NOUN
admet-557	167	176	(	(	PUNCT
admet-557	167	177	%	%	NOUN
admet-557	167	178	rsd	rsd	NOUN
admet-557	167	179	)	)	PUNCT
admet-557	167	180	6.47	6.47	NUM
admet-557	167	181	11.6	11.6	NUM
admet-557	167	182	5.28	5.28	NUM
admet-557	167	183	11.7	11.7	NUM
admet-557	167	184	accuracy	accuracy	NOUN
admet-557	167	185	(	(	PUNCT
admet-557	167	186	%	%	INTJ
admet-557	167	187	re	re	NOUN
admet-557	167	188	)	)	PUNCT
admet-557	167	189	1.03	1.03	NUM
admet-557	167	190	0.94	0.94	NUM
admet-557	167	191	0.94	0.94	NUM
admet-557	167	192	0.86	0.86	NUM
admet-557	167	193	long	long	ADJ
admet-557	167	194	-	-	PUNCT
admet-557	167	195	term	term	NOUN
admet-557	167	196	stability	stability	NOUN
admet-557	167	197	at	at	ADP
admet-557	167	198	-80	-80	NOUN
admet-557	167	199	°	°	PROPN
admet-557	167	200	c	c	NOUN
admet-557	167	201	(	(	PUNCT
admet-557	167	202	30	30	NUM
admet-557	167	203	days	day	NOUN
admet-557	167	204	)	)	PUNCT
admet-557	167	205	lqc	lqc	NOUN
admet-557	167	206	(	(	PUNCT
admet-557	167	207	2.80	2.80	NUM
admet-557	167	208	ng	ng	PROPN
admet-557	167	209	/	/	SYM
admet-557	167	210	ml	ml	NOUN
admet-557	167	211	)	)	PUNCT
admet-557	167	212	precision	precision	NOUN
admet-557	167	213	(	(	PUNCT
admet-557	167	214	%	%	NOUN
admet-557	167	215	rsd	rsd	NOUN
admet-557	167	216	)	)	PUNCT
admet-557	167	217	4.77	4.77	NUM
admet-557	167	218	9.21	9.21	NUM
admet-557	167	219	10.2	10.2	NUM
admet-557	167	220	6.60	6.60	NUM
admet-557	167	221	accuracy	accuracy	NOUN
admet-557	167	222	(	(	PUNCT
admet-557	167	223	%	%	INTJ
admet-557	167	224	re	re	NOUN
admet-557	167	225	)	)	PUNCT
admet-557	167	226	1.01	1.01	NUM
admet-557	167	227	1.02	1.02	NUM
admet-557	167	228	0.91	0.91	NUM
admet-557	167	229	0.89	0.89	NUM
admet-557	167	230	hqc	hqc	PROPN
admet-557	167	231	(	(	PUNCT
admet-557	167	232	1493	1493	NUM
admet-557	167	233	ng	ng	PROPN
admet-557	167	234	/	/	SYM
admet-557	167	235	ml	ml	NOUN
admet-557	167	236	)	)	PUNCT
admet-557	167	237	precision	precision	NOUN
admet-557	167	238	(	(	PUNCT
admet-557	167	239	%	%	NOUN
admet-557	167	240	rsd	rsd	NOUN
admet-557	167	241	)	)	PUNCT
admet-557	167	242	4.03	4.03	NUM
admet-557	167	243	8.81	8.81	NUM
admet-557	167	244	10.2	10.2	NUM
admet-557	167	245	4.85	4.85	NUM
admet-557	167	246	accuracy	accuracy	NOUN
admet-557	167	247	(	(	PUNCT
admet-557	167	248	%	%	INTJ
admet-557	167	249	re	re	NOUN
admet-557	167	250	)	)	PUNCT
admet-557	167	251	1.04	1.04	NUM
admet-557	167	252	0.99	0.99	NUM
admet-557	167	253	0.87	0.87	NUM
admet-557	167	254	0.85	0.85	NUM
admet-557	167	255	%	%	NOUN
admet-557	167	256	rsd	rsd	NOUN
admet-557	167	257	:	:	PUNCT
admet-557	167	258	relative	relative	ADJ
admet-557	167	259	standard	standard	ADJ
admet-557	167	260	deviation	deviation	NOUN
admet-557	167	261	(	(	PUNCT
admet-557	167	262	sd	sd	NOUN
admet-557	167	263	x	x	SYM
admet-557	167	264	100	100	NUM
admet-557	167	265	/	/	SYM
admet-557	167	266	mean	mean	NOUN
admet-557	167	267	)	)	PUNCT
admet-557	167	268	%	%	NOUN
admet-557	167	269	re	re	ADP
admet-557	167	270	:	:	PUNCT
admet-557	167	271	relative	relative	ADJ
admet-557	167	272	error	error	NOUN
admet-557	167	273	(	(	PUNCT
admet-557	167	274	measured	measure	VERB
admet-557	167	275	value	value	NOUN
admet-557	167	276	/	/	SYM
admet-557	167	277	actual	actual	ADJ
admet-557	167	278	value	value	NOUN
admet-557	167	279	)	)	PUNCT
admet-557	167	280	pharmacokinetic	pharmacokinetic	ADJ
admet-557	167	281	study	study	NOUN
admet-557	167	282	the	the	DET
admet-557	167	283	sensitivity	sensitivity	NOUN
admet-557	167	284	and	and	CCONJ
admet-557	167	285	specificity	specificity	NOUN
admet-557	167	286	of	of	ADP
admet-557	167	287	the	the	DET
admet-557	167	288	assay	assay	NOUN
admet-557	167	289	were	be	AUX
admet-557	167	290	found	find	VERB
admet-557	167	291	to	to	PART
admet-557	167	292	be	be	AUX
admet-557	167	293	sufficient	sufficient	ADJ
admet-557	167	294	for	for	ADP
admet-557	167	295	accurately	accurately	ADV
admet-557	167	296	characterizing	characterize	VERB
admet-557	167	297	the	the	DET
admet-557	167	298	pharmacokinetics	pharmacokinetic	NOUN
admet-557	167	299	of	of	ADP
admet-557	167	300	enzalutamide	enzalutamide	NOUN
admet-557	167	301	,	,	PUNCT
admet-557	167	302	n	n	CCONJ
admet-557	167	303	-	-	PUNCT
admet-557	167	304	desmethylenzalutamide	desmethylenzalutamide	NOUN
admet-557	167	305	(	(	PUNCT
admet-557	167	306	released	release	VERB
admet-557	167	307	from	from	ADP
admet-557	167	308	enzalutamide	enzalutamide	ADJ
admet-557	167	309	)	)	PUNCT
admet-557	167	310	,	,	PUNCT
admet-557	167	311	darolutamide	darolutamide	NOUN
admet-557	167	312	and	and	CCONJ
admet-557	167	313	orm-15341	orm-15341	NOUN
admet-557	167	314	(	(	PUNCT
admet-557	167	315	released	release	VERB
admet-557	167	316	from	from	ADP
admet-557	167	317	darolutamide	darolutamide	NOUN
admet-557	167	318	)	)	PUNCT
admet-557	167	319	in	in	ADP
admet-557	167	320	blood	blood	NOUN
admet-557	167	321	following	follow	VERB
admet-557	167	322	cassette	cassette	NOUN
admet-557	167	323	dose	dose	VERB
admet-557	167	324	intravenous	intravenous	ADJ
admet-557	167	325	administration	administration	NOUN
admet-557	167	326	at	at	ADP
admet-557	167	327	1.0	1.0	NUM
admet-557	167	328	mg	mg	PROPN
admet-557	167	329	/	/	SYM
admet-557	167	330	kg	kg	PROPN
admet-557	167	331	dose	dose	NOUN
admet-557	167	332	of	of	ADP
admet-557	167	333	enzalutamide	enzalutamide	ADV
admet-557	167	334	and	and	CCONJ
admet-557	167	335	darolutamide	darolutamide	VERB
admet-557	167	336	to	to	PART
admet-557	167	337	male	male	VERB
admet-557	167	338	balbc	balbc	ADJ
admet-557	167	339	mice	mouse	NOUN
admet-557	167	340	.	.	PUNCT
admet-557	168	1	fig	fig	NOUN
admet-557	168	2	.	.	PUNCT
admet-557	169	1	3a	3a	PROPN
admet-557	169	2	shows	show	VERB
admet-557	169	3	mean	mean	VERB
admet-557	169	4	blood	blood	NOUN
admet-557	169	5	concentration	concentration	NOUN
admet-557	169	6	-	-	PUNCT
admet-557	169	7	time	time	NOUN
admet-557	169	8	profile	profile	NOUN
admet-557	169	9	for	for	ADP
admet-557	169	10	enzalutamide	enzalutamide	NOUN
admet-557	170	1	and	and	CCONJ
admet-557	170	2	it	it	PRON
admet-557	170	3	was	be	AUX
admet-557	170	4	quantified	quantify	VERB
admet-557	170	5	till	till	SCONJ
admet-557	170	6	168	168	NUM
admet-557	170	7	h	h	NOUN
admet-557	170	8	post	post	ADJ
admet-557	170	9	-	-	ADJ
admet-557	170	10	dosing	dosing	ADJ
admet-557	170	11	by	by	ADP
admet-557	170	12	intravenous	intravenous	ADJ
admet-557	170	13	route	route	NOUN
admet-557	170	14	.	.	PUNCT
admet-557	171	1	however	however	ADV
admet-557	171	2	the	the	DET
admet-557	171	3	blood	blood	NOUN
admet-557	171	4	concentrations	concentration	NOUN
admet-557	171	5	for	for	ADP
admet-557	171	6	n	n	CCONJ
admet-557	171	7	-	-	PUNCT
admet-557	171	8	desmethylenzalutamide	desmethylenzalutamide	NOUN
admet-557	171	9	were	be	AUX
admet-557	171	10	seen	see	VERB
admet-557	171	11	just	just	ADV
admet-557	171	12	above	above	ADP
admet-557	171	13	lloq	lloq	NOUN
admet-557	171	14	at	at	ADP
admet-557	171	15	4	4	NUM
admet-557	171	16	,	,	PUNCT
admet-557	171	17	8	8	NUM
admet-557	171	18	,	,	PUNCT
admet-557	171	19	24	24	NUM
admet-557	171	20	and	and	CCONJ
admet-557	171	21	48	48	NUM
admet-557	171	22	h	h	NOUN
admet-557	171	23	(	(	PUNCT
admet-557	171	24	ranged	range	VERB
admet-557	171	25	between	between	ADP
admet-557	171	26	1.23	1.23	NUM
admet-557	171	27	-	-	SYM
admet-557	171	28	4.30	4.30	NUM
admet-557	171	29	ng	ng	PROPN
admet-557	171	30	/	/	SYM
admet-557	171	31	ml	ml	PROPN
admet-557	171	32	)	)	PUNCT
admet-557	171	33	and	and	CCONJ
admet-557	171	34	below	below	ADP
admet-557	171	35	lloq	lloq	NOUN
admet-557	171	36	at	at	ADP
admet-557	171	37	remaining	remain	VERB
admet-557	171	38	time	time	NOUN
admet-557	171	39	points	point	NOUN
admet-557	171	40	hence	hence	ADV
admet-557	171	41	admet	admet	PROPN
admet-557	171	42	&	&	CCONJ
admet-557	171	43	dmpk	dmpk	PROPN
admet-557	171	44	6(3	6(3	PROPN
admet-557	171	45	)	)	PUNCT
admet-557	171	46	(	(	PUNCT
admet-557	171	47	2018	2018	NUM
admet-557	171	48	)	)	PUNCT
admet-557	171	49	242	242	NUM
admet-557	171	50	-	-	SYM
admet-557	171	51	257	257	NUM
admet-557	171	52	lc	lc	PROPN
admet-557	171	53	-	-	PUNCT
admet-557	171	54	ms	ms	PROPN
admet-557	171	55	/	/	SYM
admet-557	171	56	ms	ms	NOUN
admet-557	171	57	determination	determination	NOUN
admet-557	171	58	of	of	ADP
admet-557	171	59	enzalutamide	enzalutamide	ADV
admet-557	171	60	/	/	SYM
admet-557	171	61	darolutamide	darolutamide	NOUN
admet-557	171	62	with	with	ADP
admet-557	171	63	metabolites	metabolite	NOUN
admet-557	171	64	on	on	ADP
admet-557	171	65	dbs	dbs	PROPN
admet-557	171	66	doi	doi	PROPN
admet-557	171	67	:	:	PUNCT
admet-557	171	68	10.5599	10.5599	NUM
admet-557	171	69	/	/	SYM
admet-557	171	70	admet.557	admet.557	PROPN
admet-557	171	71	253	253	NUM
admet-557	171	72	pharmacokinetic	pharmacokinetic	ADJ
admet-557	171	73	parameters	parameter	NOUN
admet-557	171	74	are	be	AUX
admet-557	171	75	not	not	PART
admet-557	171	76	calculated	calculate	VERB
admet-557	171	77	for	for	ADP
admet-557	171	78	n	n	CCONJ
admet-557	171	79	-	-	PUNCT
admet-557	171	80	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	171	81	by	by	ADP
admet-557	171	82	using	use	VERB
admet-557	171	83	this	this	DET
admet-557	171	84	limited	limited	ADJ
admet-557	171	85	data	datum	NOUN
admet-557	171	86	.	.	PUNCT
admet-557	172	1	fig	fig	NOUN
admet-557	172	2	.	.	PUNCT
admet-557	173	1	3b	3b	NOUN
admet-557	173	2	shows	show	VERB
admet-557	173	3	mean	mean	VERB
admet-557	173	4	blood	blood	NOUN
admet-557	173	5	concentration	concentration	NOUN
admet-557	173	6	-	-	PUNCT
admet-557	173	7	time	time	NOUN
admet-557	173	8	profile	profile	NOUN
admet-557	173	9	for	for	ADP
admet-557	173	10	darolutamide	darolutamide	NOUN
admet-557	173	11	and	and	CCONJ
admet-557	173	12	orm-15341	orm-15341	NOUN
admet-557	173	13	,	,	PUNCT
admet-557	173	14	both	both	PRON
admet-557	173	15	were	be	AUX
admet-557	173	16	quantified	quantify	VERB
admet-557	173	17	till	till	SCONJ
admet-557	173	18	24	24	NUM
admet-557	173	19	and	and	CCONJ
admet-557	173	20	8	8	NUM
admet-557	173	21	h	h	NOUN
admet-557	173	22	,	,	PUNCT
admet-557	173	23	respectively	respectively	ADV
admet-557	173	24	post	post	ADJ
admet-557	173	25	-	-	ADJ
admet-557	173	26	dosing	dosing	ADJ
admet-557	173	27	by	by	ADP
admet-557	173	28	intravenous	intravenous	ADJ
admet-557	173	29	route	route	NOUN
admet-557	173	30	.	.	PUNCT
admet-557	174	1	summary	summary	NOUN
admet-557	174	2	of	of	ADP
admet-557	174	3	the	the	DET
admet-557	174	4	pharmacokinetic	pharmacokinetic	ADJ
admet-557	174	5	profiles	profile	NOUN
admet-557	174	6	of	of	ADP
admet-557	174	7	enzalutamide	enzalutamide	NOUN
admet-557	174	8	,	,	PUNCT
admet-557	174	9	darolutamide	darolutamide	NOUN
admet-557	174	10	and	and	CCONJ
admet-557	174	11	orm-15341	orm-15341	NOUN
admet-557	174	12	after	after	SCONJ
admet-557	174	13	single	single	ADJ
admet-557	174	14	dose	dose	PROPN
admet-557	174	15	intravenous	intravenous	PROPN
admet-557	174	16	administration	administration	NOUN
admet-557	174	17	in	in	ADP
admet-557	174	18	male	male	ADJ
admet-557	174	19	balbc	balbc	ADJ
admet-557	174	20	mice	mouse	NOUN
admet-557	174	21	were	be	AUX
admet-557	174	22	shown	show	VERB
admet-557	174	23	in	in	ADP
admet-557	174	24	table	table	NOUN
admet-557	174	25	6	6	NUM
admet-557	174	26	.	.	PUNCT
admet-557	175	1	in	in	ADP
admet-557	175	2	order	order	NOUN
admet-557	175	3	to	to	PART
admet-557	175	4	validate	validate	VERB
admet-557	175	5	this	this	DET
admet-557	175	6	method	method	NOUN
admet-557	175	7	the	the	DET
admet-557	175	8	pharmacokinetics	pharmacokinetic	NOUN
admet-557	175	9	results	result	NOUN
admet-557	175	10	of	of	ADP
admet-557	175	11	enzalutamide	enzalutamide	NOUN
admet-557	175	12	,	,	PUNCT
admet-557	175	13	darolutamide	darolutamide	NOUN
admet-557	175	14	and	and	CCONJ
admet-557	175	15	orm-15341	orm-15341	NOUN
admet-557	175	16	in	in	ADP
admet-557	175	17	the	the	DET
admet-557	175	18	present	present	ADJ
admet-557	175	19	study	study	NOUN
admet-557	175	20	were	be	AUX
admet-557	175	21	compared	compare	VERB
admet-557	175	22	with	with	ADP
admet-557	175	23	earlier	early	ADV
admet-557	175	24	reported	report	VERB
admet-557	175	25	pharmacokinetic	pharmacokinetic	ADJ
admet-557	175	26	parameters	parameter	NOUN
admet-557	175	27	determined	determine	VERB
admet-557	175	28	using	use	VERB
admet-557	175	29	plasma	plasma	NOUN
admet-557	175	30	as	as	ADP
admet-557	175	31	a	a	DET
admet-557	175	32	matrix	matrix	NOUN
admet-557	175	33	[	[	X
admet-557	175	34	19	19	NUM
admet-557	175	35	]	]	PUNCT
admet-557	175	36	and	and	CCONJ
admet-557	175	37	found	find	VERB
admet-557	175	38	that	that	SCONJ
admet-557	175	39	good	good	ADJ
admet-557	175	40	correlation	correlation	NOUN
admet-557	175	41	between	between	ADP
admet-557	175	42	both	both	DET
admet-557	175	43	measurements	measurement	NOUN
admet-557	175	44	.	.	PUNCT
admet-557	176	1	this	this	PRON
admet-557	176	2	shows	show	VERB
admet-557	176	3	that	that	SCONJ
admet-557	176	4	dbs	dbs	PROPN
admet-557	176	5	can	can	AUX
admet-557	176	6	be	be	AUX
admet-557	176	7	used	use	VERB
admet-557	176	8	as	as	ADP
admet-557	176	9	a	a	DET
admet-557	176	10	promising	promising	ADJ
admet-557	176	11	alternative	alternative	NOUN
admet-557	176	12	suitable	suitable	ADJ
admet-557	176	13	to	to	PART
admet-557	176	14	predict	predict	VERB
admet-557	176	15	exposure	exposure	NOUN
admet-557	176	16	of	of	ADP
admet-557	176	17	enzalutamide	enzalutamide	NOUN
admet-557	176	18	,	,	PUNCT
admet-557	176	19	darolutamide	darolutamide	NOUN
admet-557	176	20	and	and	CCONJ
admet-557	176	21	orm-15341	orm-15341	NOUN
admet-557	176	22	.	.	PUNCT
admet-557	177	1	n	n	CCONJ
admet-557	177	2	-	-	PUNCT
admet-557	177	3	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	177	4	pharmacokinetic	pharmacokinetic	ADJ
admet-557	177	5	parameters	parameter	NOUN
admet-557	177	6	were	be	AUX
admet-557	177	7	not	not	PART
admet-557	177	8	calculated	calculate	VERB
admet-557	177	9	due	due	ADJ
admet-557	177	10	to	to	ADP
admet-557	177	11	low	low	ADJ
admet-557	177	12	exposure	exposure	NOUN
admet-557	177	13	and	and	CCONJ
admet-557	177	14	in	in	ADP
admet-557	177	15	our	our	PRON
admet-557	177	16	earlier	early	ADJ
admet-557	177	17	study	study	NOUN
admet-557	177	18	we	we	PRON
admet-557	177	19	did	do	AUX
admet-557	177	20	not	not	PART
admet-557	177	21	calculate	calculate	VERB
admet-557	177	22	n	n	CCONJ
admet-557	177	23	-	-	PUNCT
admet-557	177	24	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	177	25	pharmacokinetic	pharmacokinetic	ADJ
admet-557	177	26	parameters	parameter	NOUN
admet-557	177	27	[	[	X
admet-557	177	28	19	19	NUM
admet-557	177	29	]	]	PUNCT
admet-557	177	30	.	.	PUNCT
admet-557	178	1	table	table	NOUN
admet-557	178	2	5	5	NUM
admet-557	178	3	.	.	PUNCT
admet-557	178	4	impact	impact	NOUN
admet-557	178	5	of	of	ADP
admet-557	178	6	hematocrit	hematocrit	ADJ
admet-557	178	7	value	value	NOUN
admet-557	178	8	of	of	ADP
admet-557	178	9	enzalutamide	enzalutamide	NOUN
admet-557	178	10	,	,	PUNCT
admet-557	178	11	n	n	CCONJ
admet-557	178	12	-	-	PUNCT
admet-557	178	13	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	178	14	,	,	PUNCT
admet-557	178	15	darolutamide	darolutamide	NOUN
admet-557	178	16	and	and	CCONJ
admet-557	178	17	orm-15341	orm-15341	NOUN
admet-557	178	18	on	on	ADP
admet-557	178	19	the	the	DET
admet-557	178	20	quality	quality	NOUN
admet-557	178	21	control	control	NOUN
admet-557	178	22	sample	sample	NOUN
admet-557	178	23	concentration	concentration	NOUN
admet-557	178	24	(	(	PUNCT
admet-557	178	25	n	n	NOUN
admet-557	178	26	=	=	SYM
admet-557	178	27	3	3	NUM
admet-557	178	28	)	)	PUNCT
admet-557	178	29	concentration	concentration	NOUN
admet-557	178	30	spiked	spike	VERB
admet-557	178	31	2.80	2.80	NUM
admet-557	178	32	ng	ng	PROPN
admet-557	178	33	/	/	SYM
admet-557	178	34	ml	ml	PROPN
admet-557	178	35	1493	1493	NUM
admet-557	178	36	ng	ng	PROPN
admet-557	178	37	/	/	SYM
admet-557	178	38	ml	ml	NOUN
admet-557	178	39	concentration	concentration	NOUN
admet-557	178	40	found	find	VERB
admet-557	178	41	(	(	PUNCT
admet-557	178	42	ng	ng	NOUN
admet-557	178	43	/	/	SYM
admet-557	178	44	ml	ml	NOUN
admet-557	178	45	)	)	PUNCT
admet-557	178	46	hematocrit	hematocrit	NOUN
admet-557	178	47	(	(	PUNCT
admet-557	178	48	%	%	NOUN
admet-557	178	49	)	)	PUNCT
admet-557	178	50	25	25	NUM
admet-557	178	51	35	35	NUM
admet-557	178	52	45	45	NUM
admet-557	178	53	25	25	NUM
admet-557	178	54	35	35	NUM
admet-557	178	55	45	45	NUM
admet-557	178	56	enzalutamide	enzalutamide	ADV
admet-557	178	57	2.63	2.63	NUM
admet-557	178	58	2.53	2.53	NUM
admet-557	178	59	2.79	2.79	NUM
admet-557	178	60	150	150	NUM
admet-557	178	61	6	6	NUM
admet-557	178	62	1561	1561	NUM
admet-557	178	63	1526	1526	NUM
admet-557	178	64	n	n	CCONJ
admet-557	178	65	-	-	PUNCT
admet-557	178	66	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	178	67	2.96	2.96	NUM
admet-557	178	68	3.04	3.04	NUM
admet-557	178	69	2.78	2.78	NUM
admet-557	178	70	155	155	NUM
admet-557	178	71	4	4	NUM
admet-557	178	72	1498	1498	NUM
admet-557	178	73	1585	1585	NUM
admet-557	178	74	darolutamide	darolutamide	NOUN
admet-557	178	75	2.80	2.80	NUM
admet-557	178	76	2.85	2.85	NUM
admet-557	178	77	2.86	2.86	NUM
admet-557	178	78	153	153	NUM
admet-557	178	79	7	7	NUM
admet-557	178	80	1633	1633	NUM
admet-557	178	81	1583	1583	NUM
admet-557	178	82	orm-15341	orm-15341	NOUN
admet-557	178	83	3.07	3.07	NUM
admet-557	178	84	3.06	3.06	NUM
admet-557	178	85	2.56	2.56	NUM
admet-557	178	86	146	146	NUM
admet-557	178	87	6	6	NUM
admet-557	178	88	1604	1604	NUM
admet-557	178	89	1498	1498	NUM
admet-557	178	90	accuracy	accuracy	NOUN
admet-557	178	91	(	(	PUNCT
admet-557	178	92	%	%	INTJ
admet-557	178	93	re	re	NOUN
admet-557	178	94	)	)	PUNCT
admet-557	178	95	enzalutamide	enzalutamide	ADV
admet-557	178	96	0.94	0.94	NUM
admet-557	178	97	0.90	0.90	NUM
admet-557	178	98	1.00	1.00	NUM
admet-557	178	99	1.01	1.01	NUM
admet-557	178	100	1.05	1.05	NUM
admet-557	178	101	1.02	1.02	NUM
admet-557	178	102	n	n	CCONJ
admet-557	178	103	-	-	PUNCT
admet-557	178	104	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	178	105	1.06	1.06	NUM
admet-557	178	106	1.09	1.09	NUM
admet-557	178	107	0.99	0.99	NUM
admet-557	178	108	1.04	1.04	NUM
admet-557	178	109	1.00	1.00	NUM
admet-557	178	110	1.06	1.06	NUM
admet-557	178	111	darolutamide	darolutamide	NOUN
admet-557	178	112	1.00	1.00	NUM
admet-557	178	113	1.02	1.02	NUM
admet-557	178	114	1.02	1.02	NUM
admet-557	178	115	1.03	1.03	NUM
admet-557	178	116	1.09	1.09	NUM
admet-557	178	117	1.06	1.06	NUM
admet-557	178	118	orm-15341	orm-15341	NOUN
admet-557	178	119	1.10	1.10	NUM
admet-557	178	120	1.09	1.09	NUM
admet-557	178	121	0.91	0.91	NUM
admet-557	178	122	0.98	0.98	NUM
admet-557	178	123	1.07	1.07	NUM
admet-557	178	124	1.00	1.00	NUM
admet-557	178	125	precision	precision	NOUN
admet-557	178	126	(	(	PUNCT
admet-557	178	127	%	%	NOUN
admet-557	178	128	rsd	rsd	NOUN
admet-557	178	129	)	)	PUNCT
admet-557	178	130	enzalutamide	enzalutamide	ADV
admet-557	178	131	3.96	3.96	NUM
admet-557	178	132	2.38	2.38	NUM
admet-557	178	133	5.89	5.89	NUM
admet-557	178	134	10.2	10.2	NUM
admet-557	178	135	7.10	7.10	NUM
admet-557	178	136	9.85	9.85	NUM
admet-557	178	137	n	n	CCONJ
admet-557	178	138	-	-	PUNCT
admet-557	178	139	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	178	140	7.12	7.12	NUM
admet-557	178	141	7.33	7.33	NUM
admet-557	178	142	8.65	8.65	NUM
admet-557	178	143	5.87	5.87	NUM
admet-557	178	144	10.6	10.6	NUM
admet-557	178	145	8.36	8.36	NUM
admet-557	178	146	darolutamide	darolutamide	NOUN
admet-557	178	147	9.21	9.21	NUM
admet-557	178	148	7.12	7.12	NUM
admet-557	178	149	2.35	2.35	NUM
admet-557	178	150	11.2	11.2	NUM
admet-557	178	151	12.3	12.3	NUM
admet-557	178	152	10.9	10.9	NUM
admet-557	178	153	orm-15341	orm-15341	NOUN
admet-557	178	154	8.18	8.18	NUM
admet-557	178	155	5.55	5.55	NUM
admet-557	178	156	9.38	9.38	NUM
admet-557	178	157	12.4	12.4	NUM
admet-557	178	158	2.95	2.95	NUM
admet-557	178	159	12.3	12.3	NUM
admet-557	178	160	table	table	NOUN
admet-557	178	161	6	6	NUM
admet-557	178	162	.	.	PUNCT
admet-557	178	163	pharmacokinetic	pharmacokinetic	ADJ
admet-557	178	164	parameters	parameter	NOUN
admet-557	178	165	for	for	ADP
admet-557	178	166	enzaluatmide	enzaluatmide	ADJ
admet-557	178	167	,	,	PUNCT
admet-557	178	168	daroluatmide	daroluatmide	ADV
admet-557	178	169	and	and	CCONJ
admet-557	178	170	orm-15341	orm-15341	NOUN
admet-557	178	171	following	follow	VERB
admet-557	178	172	cassette	cassette	NOUN
admet-557	178	173	dose	dose	VERB
admet-557	178	174	intravenous	intravenous	ADJ
admet-557	178	175	administration	administration	NOUN
admet-557	178	176	to	to	PART
admet-557	178	177	mice	mice	VERB
admet-557	178	178	at	at	ADP
admet-557	178	179	1	1	NUM
admet-557	178	180	mg	mg	PROPN
admet-557	178	181	/	/	SYM
admet-557	178	182	kg	kg	PROPN
admet-557	178	183	pk	pk	NOUN
admet-557	178	184	parameters	parameter	NOUN
admet-557	178	185	enzalutamide	enzalutamide	ADP
admet-557	178	186	darolutamide	darolutamide	ADJ
admet-557	178	187	orm-15341	orm-15341	NOUN
admet-557	178	188	auc(0-	auc(0-	NUM
admet-557	178	189	)	)	PUNCT
admet-557	179	1	(	(	PUNCT
admet-557	179	2	ng	ng	PROPN
admet-557	179	3			PROPN
admet-557	179	4	h	h	PROPN
admet-557	179	5	/	/	SYM
admet-557	179	6	ml	ml	NOUN
admet-557	179	7	)	)	PUNCT
admet-557	179	8	24332	24332	NUM
admet-557	179	9	1514	1514	NUM
admet-557	179	10	2214	2214	NUM
admet-557	179	11	c0	c0	NOUN
admet-557	179	12	(	(	PUNCT
admet-557	179	13	ng	ng	PROPN
admet-557	179	14	/	/	SYM
admet-557	179	15	ml	ml	PROPN
admet-557	179	16	)	)	PUNCT
admet-557	179	17	1180	1180	NUM
admet-557	179	18	3042	3042	NUM
admet-557	179	19	1251	1251	NUM
admet-557	179	20	t1/2	t1/2	NOUN
admet-557	179	21	(	(	PUNCT
admet-557	179	22	h	h	NOUN
admet-557	179	23	)	)	PUNCT
admet-557	179	24	31.0	31.0	NUM
admet-557	179	25	4.64	4.64	NUM
admet-557	179	26	1.56	1.56	NUM
admet-557	179	27	cl	cl	NOUN
admet-557	179	28	(	(	PUNCT
admet-557	179	29	ml	ml	NOUN
admet-557	179	30	/	/	SYM
admet-557	179	31	min	min	NOUN
admet-557	179	32	/	/	SYM
admet-557	179	33	kg	kg	NOUN
admet-557	179	34	)	)	PUNCT
admet-557	179	35	0.68	0.68	NUM
admet-557	179	36	11.0	11.0	NUM
admet-557	179	37	--	--	PUNCT
admet-557	179	38	vd	vd	NOUN
admet-557	179	39	(	(	PUNCT
admet-557	179	40	l	l	NOUN
admet-557	179	41	/	/	SYM
admet-557	179	42	kg	kg	NOUN
admet-557	179	43	)	)	PUNCT
admet-557	179	44	1.84	1.84	NUM
admet-557	179	45	4.42	4.42	NUM
admet-557	179	46	--	--	PUNCT
admet-557	179	47	r.	r.	PROPN
admet-557	179	48	mullangi	mullangi	VERB
admet-557	179	49	et	et	PROPN
admet-557	179	50	al	al	PROPN
admet-557	179	51	.	.	PROPN
admet-557	179	52	admet	admet	PROPN
admet-557	179	53	&	&	CCONJ
admet-557	179	54	dmpk	dmpk	PROPN
admet-557	179	55	6(3	6(3	PROPN
admet-557	179	56	)	)	PUNCT
admet-557	179	57	(	(	PUNCT
admet-557	179	58	2018	2018	NUM
admet-557	179	59	)	)	PUNCT
admet-557	179	60	242	242	NUM
admet-557	179	61	-	-	SYM
admet-557	179	62	257	257	NUM
admet-557	179	63	254	254	NUM
admet-557	179	64	a	a	PRON
admet-557	179	65	)	)	PUNCT
admet-557	179	66	0	0	NUM
admet-557	179	67	24	24	NUM
admet-557	179	68	48	48	NUM
admet-557	179	69	72	72	NUM
admet-557	179	70	96	96	NUM
admet-557	179	71	120	120	NUM
admet-557	179	72	144	144	NUM
admet-557	179	73	168	168	NUM
admet-557	179	74	1	1	NUM
admet-557	179	75	10	10	NUM
admet-557	179	76	100	100	NUM
admet-557	179	77	1000	1000	NUM
admet-557	179	78	10000	10000	NUM
admet-557	179	79	enzalutamide	enzalutamide	ADJ
admet-557	179	80	time	time	NOUN
admet-557	179	81	(	(	PUNCT
admet-557	179	82	h	h	NOUN
admet-557	179	83	)	)	PUNCT
admet-557	179	84	c	c	NOUN
admet-557	179	85	o	o	NOUN
admet-557	179	86	n	n	ADP
admet-557	179	87	c	c	NOUN
admet-557	179	88	e	e	X
admet-557	179	89	n	n	X
admet-557	179	90	tr	tr	DET
admet-557	179	91	a	a	DET
admet-557	179	92	ti	ti	NOUN
admet-557	179	93	o	o	NOUN
admet-557	179	94	n	n	CCONJ
admet-557	180	1	i	i	PRON
admet-557	181	1	n	n	PROPN
admet-557	181	2	b	b	PROPN
admet-557	182	1	lo	lo	NOUN
admet-557	182	2	o	o	NOUN
admet-557	183	1	d	d	X
admet-557	183	2	(	(	PUNCT
admet-557	183	3	n	n	CCONJ
admet-557	183	4	g	g	PROPN
admet-557	183	5	/m	/m	X
admet-557	183	6	l	l	NOUN
admet-557	183	7	)	)	PUNCT
admet-557	183	8	0	0	NUM
admet-557	183	9	4	4	NUM
admet-557	183	10	8	8	NUM
admet-557	183	11	12	12	NUM
admet-557	183	12	16	16	NUM
admet-557	183	13	20	20	NUM
admet-557	183	14	24	24	NUM
admet-557	183	15	1	1	NUM
admet-557	183	16	10	10	NUM
admet-557	183	17	100	100	NUM
admet-557	183	18	1000	1000	NUM
admet-557	183	19	10000	10000	NUM
admet-557	183	20	enzalutamide	enzalutamide	ADJ
admet-557	183	21	time	time	NOUN
admet-557	183	22	(	(	PUNCT
admet-557	183	23	h	h	NOUN
admet-557	183	24	)	)	PUNCT
admet-557	183	25	b	b	NOUN
admet-557	183	26	)	)	PUNCT
admet-557	183	27	0	0	NUM
admet-557	183	28	4	4	NUM
admet-557	183	29	8	8	NUM
admet-557	183	30	12	12	NUM
admet-557	183	31	16	16	NUM
admet-557	183	32	20	20	NUM
admet-557	183	33	24	24	NUM
admet-557	183	34	1	1	NUM
admet-557	183	35	10	10	NUM
admet-557	183	36	100	100	NUM
admet-557	183	37	1000	1000	NUM
admet-557	183	38	10000	10000	NUM
admet-557	183	39	darolutamide	darolutamide	ADJ
admet-557	183	40	time	time	NOUN
admet-557	183	41	(	(	PUNCT
admet-557	183	42	h	h	NOUN
admet-557	183	43	)	)	PUNCT
admet-557	183	44	c	c	NOUN
admet-557	183	45	o	o	NOUN
admet-557	183	46	n	n	ADP
admet-557	183	47	c	c	NOUN
admet-557	183	48	e	e	X
admet-557	183	49	n	n	X
admet-557	183	50	tr	tr	DET
admet-557	183	51	a	a	DET
admet-557	183	52	ti	ti	NOUN
admet-557	183	53	o	o	NOUN
admet-557	183	54	n	n	CCONJ
admet-557	184	1	i	i	PRON
admet-557	184	2	n	n	PROPN
admet-557	184	3	b	b	PROPN
admet-557	184	4	lo	lo	NOUN
admet-557	185	1	o	o	NOUN
admet-557	185	2	d	d	X
admet-557	185	3	(	(	PUNCT
admet-557	185	4	n	n	CCONJ
admet-557	185	5	g	g	PROPN
admet-557	185	6	/m	/m	PUNCT
admet-557	185	7	l	l	NOUN
admet-557	185	8	)	)	PUNCT
admet-557	185	9	orm-15341	orm-15341	NOUN
admet-557	185	10	figure	figure	NOUN
admet-557	185	11	3	3	NUM
admet-557	185	12	.	.	PUNCT
admet-557	186	1	mean	mean	VERB
admet-557	186	2	blood	blood	NOUN
admet-557	186	3	concentration	concentration	NOUN
admet-557	186	4	-	-	PUNCT
admet-557	186	5	time	time	NOUN
admet-557	186	6	profile	profile	NOUN
admet-557	186	7	of	of	ADP
admet-557	186	8	(	(	PUNCT
admet-557	186	9	a	a	X
admet-557	186	10	)	)	PUNCT
admet-557	186	11	enzalutamide	enzalutamide	NOUN
admet-557	186	12	in	in	ADP
admet-557	186	13	mice	mice	NOUN
admet-557	186	14	blood	blood	NOUN
admet-557	186	15	following	follow	VERB
admet-557	186	16	intravenous	intravenous	ADJ
admet-557	186	17	cassette	cassette	NOUN
admet-557	186	18	dosing	dose	VERB
admet-557	186	19	of	of	ADP
admet-557	186	20	enzalutamide	enzalutamide	ADV
admet-557	186	21	and	and	CCONJ
admet-557	186	22	darolutamide	darolutamide	VERB
admet-557	186	23	to	to	ADP
admet-557	186	24	mice	mouse	NOUN
admet-557	186	25	at	at	ADP
admet-557	186	26	1.0	1.0	NUM
admet-557	186	27	mg	mg	PROPN
admet-557	186	28	/	/	SYM
admet-557	186	29	kg	kg	PROPN
admet-557	186	30	;	;	PUNCT
admet-557	186	31	(	(	PUNCT
admet-557	186	32	b	b	X
admet-557	186	33	)	)	PUNCT
admet-557	186	34	darolutamide	darolutamide	NOUN
admet-557	186	35	and	and	CCONJ
admet-557	186	36	orm-15341	orm-15341	NOUN
admet-557	186	37	(	(	PUNCT
admet-557	186	38	released	release	VERB
admet-557	186	39	from	from	ADP
admet-557	186	40	darolutamide	darolutamide	NOUN
admet-557	186	41	)	)	PUNCT
admet-557	186	42	in	in	ADP
admet-557	186	43	mice	mice	NOUN
admet-557	186	44	blood	blood	NOUN
admet-557	186	45	following	follow	VERB
admet-557	186	46	intravenous	intravenous	ADJ
admet-557	186	47	cassette	cassette	NOUN
admet-557	186	48	dosing	dose	VERB
admet-557	186	49	of	of	ADP
admet-557	186	50	enzalutamide	enzalutamide	ADV
admet-557	186	51	and	and	CCONJ
admet-557	186	52	darolutamide	darolutamide	VERB
admet-557	186	53	to	to	ADP
admet-557	186	54	mice	mouse	NOUN
admet-557	186	55	at	at	ADP
admet-557	186	56	1.0	1.0	NUM
admet-557	186	57	mg	mg	PROPN
admet-557	186	58	/	/	SYM
admet-557	186	59	kg	kg	PROPN
admet-557	186	60	.	.	PUNCT
admet-557	187	1	discussion	discussion	NOUN
admet-557	187	2	the	the	DET
admet-557	187	3	objective	objective	NOUN
admet-557	187	4	of	of	ADP
admet-557	187	5	the	the	DET
admet-557	187	6	present	present	ADJ
admet-557	187	7	method	method	NOUN
admet-557	187	8	was	be	AUX
admet-557	187	9	to	to	PART
admet-557	187	10	develop	develop	VERB
admet-557	187	11	and	and	CCONJ
admet-557	187	12	validate	validate	VERB
admet-557	187	13	a	a	DET
admet-557	187	14	new	new	ADJ
admet-557	187	15	simple	simple	ADJ
admet-557	187	16	,	,	PUNCT
admet-557	187	17	rapid	rapid	ADJ
admet-557	187	18	and	and	CCONJ
admet-557	187	19	sensitive	sensitive	ADJ
admet-557	187	20	dbs	dbs	NOUN
admet-557	187	21	method	method	NOUN
admet-557	187	22	for	for	ADP
admet-557	187	23	simultaneous	simultaneous	ADJ
admet-557	187	24	quantification	quantification	NOUN
admet-557	187	25	of	of	ADP
admet-557	187	26	enzalutamide	enzalutamide	NOUN
admet-557	187	27	,	,	PUNCT
admet-557	187	28	n	n	CCONJ
admet-557	187	29	-	-	PUNCT
admet-557	187	30	desemthylenzalutamide	desemthylenzalutamide	NOUN
admet-557	187	31	,	,	PUNCT
admet-557	187	32	darolutamide	darolutamide	NOUN
admet-557	187	33	and	and	CCONJ
admet-557	187	34	orm-15341	orm-15341	NOUN
admet-557	187	35	in	in	ADP
admet-557	187	36	mice	mouse	NOUN
admet-557	187	37	blood	blood	NOUN
admet-557	187	38	and	and	CCONJ
admet-557	187	39	apply	apply	VERB
admet-557	187	40	to	to	ADP
admet-557	187	41	a	a	DET
admet-557	187	42	pharmacokinetic	pharmacokinetic	ADJ
admet-557	187	43	study	study	NOUN
admet-557	187	44	in	in	ADP
admet-557	187	45	mice	mouse	NOUN
admet-557	187	46	.	.	PUNCT
admet-557	188	1	dbs	dbs	PROPN
admet-557	189	1	[	[	X
admet-557	189	2	whatman	whatman	NOUN
admet-557	189	3	dmpk	dmpk	PROPN
admet-557	189	4	fta	fta	PROPN
admet-557	189	5	or	or	CCONJ
admet-557	189	6	autocollect	autocollect	PROPN
admet-557	189	7	dbs	dbs	PROPN
admet-557	189	8	(	(	PUNCT
admet-557	189	9	ahlstrom	ahlstrom	ADJ
admet-557	189	10	-	-	PUNCT
admet-557	189	11	munksjo	munksjo	NOUN
admet-557	189	12	)	)	PUNCT
admet-557	189	13	cards	card	NOUN
admet-557	189	14	]	]	PUNCT
admet-557	189	15	is	be	AUX
admet-557	189	16	increasingly	increasingly	ADV
admet-557	189	17	becoming	become	VERB
admet-557	189	18	an	an	DET
admet-557	189	19	important	important	ADJ
admet-557	189	20	tool	tool	NOUN
admet-557	189	21	in	in	ADP
admet-557	189	22	preclinical	preclinical	ADJ
admet-557	189	23	drug	drug	NOUN
admet-557	189	24	development	development	NOUN
admet-557	189	25	,	,	PUNCT
admet-557	189	26	pharmacokinetic	pharmacokinetic	ADJ
admet-557	189	27	/	/	SYM
admet-557	189	28	toxicity	toxicity	NOUN
admet-557	189	29	studies	study	NOUN
admet-557	189	30	,	,	PUNCT
admet-557	189	31	neonatal	neonatal	ADJ
admet-557	189	32	screening	screening	NOUN
admet-557	189	33	,	,	PUNCT
admet-557	189	34	clinical	clinical	ADJ
admet-557	189	35	pharmacology	pharmacology	NOUN
admet-557	189	36	,	,	PUNCT
admet-557	189	37	forensic	forensic	ADJ
admet-557	189	38	toxicology	toxicology	NOUN
admet-557	189	39	,	,	PUNCT
admet-557	189	40	doping	dope	VERB
admet-557	189	41	analysis	analysis	NOUN
admet-557	189	42	and	and	CCONJ
admet-557	189	43	therapeutic	therapeutic	ADJ
admet-557	189	44	drug	drug	NOUN
admet-557	189	45	monitoring	monitoring	NOUN
admet-557	189	46	.	.	PUNCT
admet-557	190	1	dbs	dbs	PROPN
admet-557	190	2	method	method	NOUN
admet-557	190	3	offers	offer	VERB
admet-557	190	4	several	several	ADJ
admet-557	190	5	advantages	advantage	NOUN
admet-557	190	6	like	like	ADP
admet-557	190	7	reduced	reduce	VERB
admet-557	190	8	blood	blood	NOUN
admet-557	190	9	/	/	SYM
admet-557	190	10	plasma	plasma	NOUN
admet-557	190	11	/	/	SYM
admet-557	190	12	serum	serum	NOUN
admet-557	190	13	volume	volume	NOUN
admet-557	190	14	per	per	ADP
admet-557	190	15	time	time	NOUN
admet-557	190	16	point	point	NOUN
admet-557	190	17	,	,	PUNCT
admet-557	190	18	minimally	minimally	ADV
admet-557	190	19	invasive	invasive	ADJ
admet-557	190	20	,	,	PUNCT
admet-557	190	21	ease	ease	NOUN
admet-557	190	22	and	and	CCONJ
admet-557	190	23	safety	safety	NOUN
admet-557	190	24	in	in	ADP
admet-557	190	25	handling	handling	NOUN
admet-557	190	26	,	,	PUNCT
admet-557	190	27	reduce	reduce	VERB
admet-557	190	28	risk	risk	NOUN
admet-557	190	29	of	of	ADP
admet-557	190	30	infection	infection	NOUN
admet-557	190	31	when	when	SCONJ
admet-557	190	32	compared	compare	VERB
admet-557	190	33	with	with	ADP
admet-557	190	34	conventional	conventional	ADJ
admet-557	190	35	wet	wet	ADJ
admet-557	190	36	sampling	sampling	NOUN
admet-557	190	37	.	.	PUNCT
admet-557	191	1	it	it	PRON
admet-557	191	2	offers	offer	VERB
admet-557	191	3	potential	potential	ADJ
admet-557	191	4	cost	cost	NOUN
admet-557	191	5	saving	saving	NOUN
admet-557	191	6	in	in	ADP
admet-557	191	7	storage	storage	NOUN
admet-557	191	8	,	,	PUNCT
admet-557	191	9	shipment	shipment	NOUN
admet-557	191	10	,	,	PUNCT
admet-557	191	11	sample	sample	NOUN
admet-557	191	12	processing	processing	NOUN
admet-557	191	13	time	time	NOUN
admet-557	191	14	(	(	PUNCT
admet-557	191	15	usually	usually	ADV
admet-557	191	16	done	do	VERB
admet-557	191	17	at	at	ADP
admet-557	191	18	room	room	NOUN
admet-557	191	19	temperature	temperature	NOUN
admet-557	191	20	)	)	PUNCT
admet-557	191	21	and	and	CCONJ
admet-557	191	22	increase	increase	VERB
admet-557	191	23	in	in	ADP
admet-557	191	24	throughput	throughput	NOUN
admet-557	191	25	etc	etc	X
admet-557	192	1	[	[	X
admet-557	192	2	28,29	28,29	NUM
admet-557	192	3	]	]	PUNCT
admet-557	192	4	.	.	PUNCT
admet-557	193	1	admet	admet	PROPN
admet-557	193	2	&	&	CCONJ
admet-557	193	3	dmpk	dmpk	PROPN
admet-557	193	4	6(3	6(3	PROPN
admet-557	193	5	)	)	PUNCT
admet-557	193	6	(	(	PUNCT
admet-557	193	7	2018	2018	NUM
admet-557	193	8	)	)	PUNCT
admet-557	193	9	242	242	NUM
admet-557	193	10	-	-	SYM
admet-557	193	11	257	257	NUM
admet-557	193	12	lc	lc	PROPN
admet-557	193	13	-	-	PUNCT
admet-557	193	14	ms	ms	PROPN
admet-557	193	15	/	/	SYM
admet-557	193	16	ms	ms	NOUN
admet-557	193	17	determination	determination	NOUN
admet-557	193	18	of	of	ADP
admet-557	193	19	enzalutamide	enzalutamide	ADV
admet-557	193	20	/	/	SYM
admet-557	193	21	darolutamide	darolutamide	NOUN
admet-557	193	22	with	with	ADP
admet-557	193	23	metabolites	metabolite	NOUN
admet-557	193	24	on	on	ADP
admet-557	193	25	dbs	dbs	PROPN
admet-557	193	26	doi	doi	PROPN
admet-557	193	27	:	:	PUNCT
admet-557	193	28	10.5599	10.5599	NUM
admet-557	193	29	/	/	SYM
admet-557	193	30	admet.557	admet.557	PROPN
admet-557	193	31	255	255	NUM
admet-557	193	32	to	to	PART
admet-557	193	33	achieve	achieve	VERB
admet-557	193	34	a	a	DET
admet-557	193	35	dbs	dbs	NOUN
admet-557	193	36	method	method	NOUN
admet-557	193	37	for	for	ADP
admet-557	193	38	the	the	DET
admet-557	193	39	first	first	ADJ
admet-557	193	40	-	-	PUNCT
admet-557	193	41	time	time	NOUN
admet-557	193	42	for	for	ADP
admet-557	193	43	second	second	ADJ
admet-557	193	44	generation	generation	NOUN
admet-557	193	45	non	non	ADJ
admet-557	193	46	-	-	ADJ
admet-557	193	47	steroidal	steroidal	ADJ
admet-557	193	48	anti	anti	ADJ
admet-557	193	49	-	-	ADJ
admet-557	193	50	androgens	androgens	ADJ
admet-557	193	51	namely	namely	ADV
admet-557	193	52	enzalutamide	enzalutamide	ADV
admet-557	193	53	and	and	CCONJ
admet-557	193	54	darolutamide	darolutamide	ADV
admet-557	193	55	along	along	ADV
admet-557	193	56	with	with	ADP
admet-557	193	57	its	its	PRON
admet-557	193	58	active	active	ADJ
admet-557	193	59	metabolite	metabolite	NOUN
admet-557	193	60	(	(	PUNCT
admet-557	193	61	n	n	CCONJ
admet-557	193	62	-	-	PUNCT
admet-557	193	63	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	193	64	and	and	CCONJ
admet-557	193	65	orm15341	orm15341	NOUN
admet-557	193	66	,	,	PUNCT
admet-557	193	67	respectively	respectively	ADV
admet-557	193	68	)	)	PUNCT
admet-557	193	69	during	during	ADP
admet-557	193	70	method	method	NOUN
admet-557	193	71	development	development	NOUN
admet-557	193	72	different	different	ADJ
admet-557	193	73	options	option	NOUN
admet-557	193	74	were	be	AUX
admet-557	193	75	evaluated	evaluate	VERB
admet-557	193	76	to	to	PART
admet-557	193	77	optimize	optimize	VERB
admet-557	193	78	dbs	dbs	PROPN
admet-557	193	79	sample	sample	NOUN
admet-557	193	80	extraction	extraction	NOUN
admet-557	193	81	and	and	CCONJ
admet-557	193	82	chromatography	chromatography	NOUN
admet-557	193	83	.	.	PUNCT
admet-557	194	1	recovery	recovery	NOUN
admet-557	194	2	was	be	AUX
admet-557	194	3	very	very	ADV
admet-557	194	4	poor	poor	ADJ
admet-557	194	5	(	(	PUNCT
admet-557	194	6	<	<	X
admet-557	194	7	8	8	NUM
admet-557	194	8	%	%	NOUN
admet-557	194	9	)	)	PUNCT
admet-557	194	10	with	with	ADP
admet-557	194	11	organic	organic	ADJ
admet-557	194	12	solvents	solvent	NOUN
admet-557	194	13	(	(	PUNCT
admet-557	194	14	tbme	tbme	NOUN
admet-557	194	15	,	,	PUNCT
admet-557	194	16	ethyl	ethyl	PROPN
admet-557	194	17	acetate	acetate	NOUN
admet-557	194	18	,	,	PUNCT
admet-557	194	19	methanol	methanol	NOUN
admet-557	194	20	and	and	CCONJ
admet-557	194	21	acetonitrile	acetonitrile	NOUN
admet-557	194	22	)	)	PUNCT
admet-557	194	23	for	for	ADP
admet-557	194	24	all	all	DET
admet-557	194	25	the	the	DET
admet-557	194	26	analytes	analyte	NOUN
admet-557	194	27	.	.	PUNCT
admet-557	195	1	then	then	ADV
admet-557	195	2	combination	combination	NOUN
admet-557	195	3	of	of	ADP
admet-557	195	4	methanol	methanol	NOUN
admet-557	195	5	/	/	SYM
admet-557	195	6	acetonitrile	acetonitrile	NOUN
admet-557	195	7	:	:	PUNCT
admet-557	195	8	water	water	NOUN
admet-557	195	9	in	in	ADP
admet-557	195	10	various	various	ADJ
admet-557	195	11	ratios	ratio	NOUN
admet-557	195	12	were	be	AUX
admet-557	195	13	systematically	systematically	ADV
admet-557	195	14	explored	explore	VERB
admet-557	195	15	.	.	PUNCT
admet-557	196	1	the	the	DET
admet-557	196	2	samples	sample	NOUN
admet-557	196	3	extracted	extract	VERB
admet-557	196	4	with	with	ADP
admet-557	196	5	acetonitrile	acetonitrile	NOUN
admet-557	196	6	:	:	PUNCT
admet-557	196	7	water	water	NOUN
admet-557	196	8	(	(	PUNCT
admet-557	196	9	80:20	80:20	NUM
admet-557	196	10	;	;	PUNCT
admet-557	196	11	50:50	50:50	NUM
admet-557	196	12	and	and	CCONJ
admet-557	196	13	20:80	20:80	NUM
admet-557	196	14	,	,	PUNCT
admet-557	196	15	v	v	NOUN
admet-557	196	16	/	/	SYM
admet-557	196	17	v	v	NOUN
admet-557	196	18	)	)	PUNCT
admet-557	196	19	have	have	AUX
admet-557	196	20	shown	show	VERB
admet-557	196	21	low	low	ADJ
admet-557	196	22	recovery	recovery	NOUN
admet-557	196	23	(	(	PUNCT
admet-557	196	24	~12	~12	NUM
admet-557	196	25	%	%	NOUN
admet-557	196	26	)	)	PUNCT
admet-557	196	27	.	.	PUNCT
admet-557	197	1	at	at	ADP
admet-557	197	2	80:20	80:20	NUM
admet-557	197	3	,	,	PUNCT
admet-557	197	4	50:50	50:50	NUM
admet-557	197	5	and	and	CCONJ
admet-557	197	6	20:80	20:80	NUM
admet-557	197	7	methanol	methanol	NOUN
admet-557	197	8	:	:	PUNCT
admet-557	197	9	water	water	NOUN
admet-557	197	10	v	v	ADP
admet-557	197	11	/	/	SYM
admet-557	197	12	v	v	NOUN
admet-557	197	13	ratios	ratio	NOUN
admet-557	197	14	the	the	DET
admet-557	197	15	recoveries	recovery	NOUN
admet-557	197	16	ranged	range	VERB
admet-557	197	17	between	between	ADP
admet-557	197	18	2232	2232	NUM
admet-557	197	19	%	%	NOUN
admet-557	197	20	but	but	CCONJ
admet-557	197	21	not	not	PART
admet-557	197	22	reproducible	reproducible	VERB
admet-557	197	23	for	for	ADP
admet-557	197	24	all	all	DET
admet-557	197	25	the	the	DET
admet-557	197	26	analytes	analyte	NOUN
admet-557	197	27	.	.	PUNCT
admet-557	198	1	water	water	NOUN
admet-557	198	2	as	as	ADP
admet-557	198	3	an	an	DET
admet-557	198	4	extraction	extraction	NOUN
admet-557	198	5	solvent	solvent	NOUN
admet-557	198	6	gave	give	VERB
admet-557	198	7	good	good	ADJ
admet-557	198	8	recovery	recovery	NOUN
admet-557	198	9	for	for	ADP
admet-557	198	10	the	the	DET
admet-557	198	11	analytes	analyte	NOUN
admet-557	198	12	(	(	PUNCT
admet-557	198	13	~47	~47	NOUN
admet-557	198	14	-	-	PUNCT
admet-557	198	15	50	50	NUM
admet-557	198	16	%	%	NOUN
admet-557	198	17	for	for	ADP
admet-557	198	18	darolutamide	darolutamide	NOUN
admet-557	198	19	and	and	CCONJ
admet-557	198	20	>	>	X
admet-557	198	21	77	77	NUM
admet-557	198	22	-	-	SYM
admet-557	198	23	84	84	NUM
admet-557	198	24	%	%	NOUN
admet-557	198	25	for	for	ADP
admet-557	198	26	rest	rest	NOUN
admet-557	198	27	of	of	ADP
admet-557	198	28	the	the	DET
admet-557	198	29	analytes	analyte	NOUN
admet-557	198	30	)	)	PUNCT
admet-557	198	31	and	and	CCONJ
admet-557	198	32	data	datum	NOUN
admet-557	198	33	was	be	AUX
admet-557	198	34	consistent	consistent	ADJ
admet-557	198	35	and	and	CCONJ
admet-557	198	36	reproducible	reproducible	ADJ
admet-557	198	37	.	.	PUNCT
admet-557	199	1	in	in	ADP
admet-557	199	2	order	order	NOUN
admet-557	199	3	to	to	PART
admet-557	199	4	increase	increase	VERB
admet-557	199	5	the	the	DET
admet-557	199	6	assay	assay	NOUN
admet-557	199	7	precision	precision	NOUN
admet-557	199	8	,	,	PUNCT
admet-557	199	9	limit	limit	VERB
admet-557	199	10	the	the	DET
admet-557	199	11	variability	variability	NOUN
admet-557	199	12	between	between	ADP
admet-557	199	13	analyte(s	analyte(s	PROPN
admet-557	199	14	)	)	PUNCT
admet-557	199	15	and	and	CCONJ
admet-557	199	16	the	the	PRON
admet-557	199	17	is	be	AUX
admet-557	199	18	,	,	PUNCT
admet-557	199	19	to	to	PART
admet-557	199	20	mimic	mimic	VERB
admet-557	199	21	the	the	DET
admet-557	199	22	analyte	analyte	NOUN
admet-557	199	23	during	during	ADP
admet-557	199	24	ionization	ionization	NOUN
admet-557	199	25	,	,	PUNCT
admet-557	199	26	extraction	extraction	NOUN
admet-557	199	27	and	and	CCONJ
admet-557	199	28	chromatography	chromatography	NOUN
admet-557	199	29	we	we	PRON
admet-557	199	30	have	have	AUX
admet-557	199	31	used	use	VERB
admet-557	199	32	apalutamide	apalutamide	NOUN
admet-557	199	33	-	-	PUNCT
admet-557	199	34	d3	d3	PROPN
admet-557	199	35	as	as	ADP
admet-557	199	36	an	an	DET
admet-557	199	37	is	be	AUX
admet-557	199	38	.	.	PUNCT
admet-557	200	1	to	to	PART
admet-557	200	2	avoid	avoid	VERB
admet-557	200	3	the	the	DET
admet-557	200	4	potentially	potentially	ADV
admet-557	200	5	co	co	ADJ
admet-557	200	6	-	-	ADJ
admet-557	200	7	eluting	eluting	ADJ
admet-557	200	8	peaks	peak	NOUN
admet-557	200	9	from	from	ADP
admet-557	200	10	whole	whole	ADJ
admet-557	200	11	blood	blood	NOUN
admet-557	200	12	,	,	PUNCT
admet-557	200	13	which	which	PRON
admet-557	200	14	will	will	AUX
admet-557	200	15	influence	influence	VERB
admet-557	200	16	the	the	DET
admet-557	200	17	ionization	ionization	NOUN
admet-557	200	18	efficiency	efficiency	NOUN
admet-557	200	19	of	of	ADP
admet-557	200	20	the	the	DET
admet-557	200	21	analytes	analyte	NOUN
admet-557	200	22	and	and	CCONJ
admet-557	200	23	the	the	PRON
admet-557	200	24	is	be	AUX
admet-557	200	25	,	,	PUNCT
admet-557	200	26	the	the	DET
admet-557	200	27	mobile	mobile	ADJ
admet-557	200	28	phase	phase	NOUN
admet-557	200	29	was	be	AUX
admet-557	200	30	optimized	optimize	VERB
admet-557	200	31	.	.	PUNCT
admet-557	201	1	the	the	DET
admet-557	201	2	attained	attain	VERB
admet-557	201	3	lloq	lloq	NOUN
admet-557	201	4	(	(	PUNCT
admet-557	201	5	0.93	0.93	NUM
admet-557	201	6	ng	ng	PROPN
admet-557	201	7	/	/	SYM
admet-557	201	8	ml	ml	NOUN
admet-557	201	9	)	)	PUNCT
admet-557	201	10	for	for	ADP
admet-557	201	11	each	each	DET
admet-557	201	12	analyte	analyte	NOUN
admet-557	201	13	(	(	PUNCT
admet-557	201	14	comparable	comparable	ADJ
admet-557	201	15	lloq	lloq	NOUN
admet-557	201	16	attained	attain	VERB
admet-557	201	17	with	with	ADP
admet-557	201	18	plasma	plasma	NOUN
admet-557	201	19	earlier	early	ADV
admet-557	201	20	reported	report	VERB
admet-557	201	21	by	by	ADP
admet-557	201	22	us	we	PRON
admet-557	201	23	)	)	PUNCT
admet-557	201	24	was	be	AUX
admet-557	201	25	sufficient	sufficient	ADJ
admet-557	201	26	to	to	PART
admet-557	201	27	quantify	quantify	VERB
admet-557	201	28	pharmacokinetic	pharmacokinetic	ADJ
admet-557	201	29	parameters	parameter	NOUN
admet-557	201	30	for	for	ADP
admet-557	201	31	enzalutamide	enzalutamide	NOUN
admet-557	201	32	,	,	PUNCT
admet-557	201	33	darolutamide	darolutamide	NOUN
admet-557	201	34	and	and	CCONJ
admet-557	201	35	orm-15341	orm-15341	NOUN
admet-557	201	36	in	in	ADP
admet-557	201	37	a	a	DET
admet-557	201	38	pharmacokinetic	pharmacokinetic	ADJ
admet-557	201	39	study	study	NOUN
admet-557	201	40	in	in	ADP
admet-557	201	41	mice	mouse	NOUN
admet-557	201	42	.	.	PUNCT
admet-557	202	1	the	the	DET
admet-557	202	2	acceptable	acceptable	ADJ
admet-557	202	3	limit	limit	NOUN
admet-557	202	4	for	for	ADP
admet-557	202	5	both	both	DET
admet-557	202	6	intraand	intraand	PROPN
admet-557	202	7	inter	inter	ADJ
admet-557	202	8	-	-	ADJ
admet-557	202	9	day	day	NOUN
admet-557	202	10	accuracy	accuracy	NOUN
admet-557	202	11	and	and	CCONJ
admet-557	202	12	precision	precision	NOUN
admet-557	202	13	is	be	AUX
admet-557	202	14	±15	±15	NOUN
admet-557	202	15	%	%	NOUN
admet-557	202	16	of	of	ADP
admet-557	202	17	the	the	DET
admet-557	202	18	nominal	nominal	ADJ
admet-557	202	19	values	value	NOUN
admet-557	202	20	for	for	ADP
admet-557	202	21	all	all	PRON
admet-557	202	22	,	,	PUNCT
admet-557	202	23	except	except	SCONJ
admet-557	202	24	for	for	ADP
admet-557	202	25	lloq	lloq	PROPN
admet-557	202	26	qc	qc	PROPN
admet-557	202	27	which	which	PRON
admet-557	202	28	should	should	AUX
admet-557	202	29	be	be	AUX
admet-557	202	30	within	within	ADP
admet-557	202	31	±20	±20	PROPN
admet-557	202	32	%	%	NOUN
admet-557	202	33	.	.	PUNCT
admet-557	203	1	in	in	ADP
admet-557	203	2	this	this	DET
admet-557	203	3	method	method	NOUN
admet-557	203	4	,	,	PUNCT
admet-557	203	5	both	both	PRON
admet-557	203	6	intraand	intraand	CCONJ
admet-557	203	7	inter	inter	ADJ
admet-557	203	8	-	-	ADJ
admet-557	203	9	day	day	NOUN
admet-557	203	10	accuracy	accuracy	NOUN
admet-557	203	11	and	and	CCONJ
admet-557	203	12	precision	precision	NOUN
admet-557	203	13	are	be	AUX
admet-557	203	14	well	well	ADV
admet-557	203	15	within	within	ADP
admet-557	203	16	this	this	DET
admet-557	203	17	limit	limit	NOUN
admet-557	203	18	,	,	PUNCT
admet-557	203	19	indicating	indicate	VERB
admet-557	203	20	that	that	SCONJ
admet-557	203	21	the	the	DET
admet-557	203	22	developed	develop	VERB
admet-557	203	23	method	method	NOUN
admet-557	203	24	is	be	AUX
admet-557	203	25	precise	precise	ADJ
admet-557	203	26	and	and	CCONJ
admet-557	203	27	accurate	accurate	ADJ
admet-557	203	28	for	for	ADP
admet-557	203	29	the	the	DET
admet-557	203	30	quantification	quantification	NOUN
admet-557	203	31	of	of	ADP
admet-557	203	32	enzalutamide	enzalutamide	NOUN
admet-557	203	33	,	,	PUNCT
admet-557	203	34	n	n	CCONJ
admet-557	203	35	-	-	PUNCT
admet-557	203	36	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	203	37	,	,	PUNCT
admet-557	203	38	darolutamide	darolutamide	NOUN
admet-557	203	39	and	and	CCONJ
admet-557	203	40	orm-15341	orm-15341	NOUN
admet-557	203	41	.	.	PUNCT
admet-557	204	1	conclusions	conclusion	NOUN
admet-557	204	2	we	we	PRON
admet-557	204	3	developed	develop	VERB
admet-557	204	4	and	and	CCONJ
admet-557	204	5	validated	validate	VERB
admet-557	204	6	an	an	DET
admet-557	204	7	analytical	analytical	ADJ
admet-557	204	8	method	method	NOUN
admet-557	204	9	for	for	ADP
admet-557	204	10	the	the	DET
admet-557	204	11	determination	determination	NOUN
admet-557	204	12	of	of	ADP
admet-557	204	13	enzalutamide	enzalutamide	ADJ
admet-557	204	14	,	,	PUNCT
admet-557	204	15	ndesmethylenzalutamide	ndesmethylenzalutamide	ADV
admet-557	204	16	,	,	PUNCT
admet-557	204	17	darolutamide	darolutamide	NOUN
admet-557	204	18	and	and	CCONJ
admet-557	204	19	orm-15341	orm-15341	NOUN
admet-557	204	20	in	in	ADP
admet-557	204	21	mice	mouse	NOUN
admet-557	204	22	dbs	dbs	NOUN
admet-557	204	23	samples	sample	NOUN
admet-557	204	24	for	for	ADP
admet-557	204	25	these	these	DET
admet-557	204	26	second	second	ADJ
admet-557	204	27	generation	generation	NOUN
admet-557	204	28	non	non	ADJ
admet-557	204	29	-	-	ADJ
admet-557	204	30	steroidal	steroidal	ADJ
admet-557	204	31	anti	anti	ADJ
admet-557	204	32	-	-	ADJ
admet-557	204	33	androgens	androgens	ADJ
admet-557	204	34	.	.	PUNCT
admet-557	205	1	the	the	DET
admet-557	205	2	method	method	NOUN
admet-557	205	3	is	be	AUX
admet-557	205	4	selective	selective	ADJ
admet-557	205	5	,	,	PUNCT
admet-557	205	6	linear	linear	ADJ
admet-557	205	7	,	,	PUNCT
admet-557	205	8	accurate	accurate	ADJ
admet-557	205	9	and	and	CCONJ
admet-557	205	10	precise	precise	ADJ
admet-557	205	11	in	in	ADP
admet-557	205	12	the	the	DET
admet-557	205	13	range	range	NOUN
admet-557	205	14	of	of	ADP
admet-557	205	15	0.932000	0.932000	NUM
admet-557	205	16	ng	ng	PROPN
admet-557	205	17	/	/	SYM
admet-557	205	18	ml	ml	PROPN
admet-557	205	19	.	.	PUNCT
admet-557	206	1	the	the	DET
admet-557	206	2	dbs	dbs	PROPN
admet-557	206	3	samples	sample	NOUN
admet-557	206	4	were	be	AUX
admet-557	206	5	stable	stable	ADJ
admet-557	206	6	in	in	ADP
admet-557	206	7	the	the	DET
admet-557	206	8	studied	study	VERB
admet-557	206	9	conditions	condition	NOUN
admet-557	206	10	and	and	CCONJ
admet-557	206	11	haematocrit	haematocrit	PROPN
admet-557	206	12	did	do	AUX
admet-557	206	13	not	not	PART
admet-557	206	14	influence	influence	VERB
admet-557	206	15	enzalutamide	enzalutamide	ADV
admet-557	206	16	,	,	PUNCT
admet-557	206	17	n	n	CCONJ
admet-557	206	18	-	-	PUNCT
admet-557	206	19	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	206	20	,	,	PUNCT
admet-557	206	21	darolutamide	darolutamide	NOUN
admet-557	206	22	and	and	CCONJ
admet-557	206	23	orm-15341	orm-15341	NOUN
admet-557	206	24	quantification	quantification	NOUN
admet-557	206	25	.	.	PUNCT
admet-557	207	1	the	the	DET
admet-557	207	2	developed	develop	VERB
admet-557	207	3	dbs	dbs	NOUN
admet-557	207	4	method	method	NOUN
admet-557	207	5	has	have	VERB
admet-557	207	6	several	several	ADJ
admet-557	207	7	advantages	advantage	NOUN
admet-557	207	8	viz	viz	PROPN
admet-557	207	9	.	.	PROPN
admet-557	207	10	,	,	PUNCT
admet-557	207	11	low	low	ADJ
admet-557	207	12	blood	blood	NOUN
admet-557	207	13	volume	volume	NOUN
admet-557	207	14	(	(	PUNCT
admet-557	207	15	25	25	NUM
admet-557	207	16	µl	µl	NOUN
admet-557	207	17	)	)	PUNCT
admet-557	207	18	,	,	PUNCT
admet-557	207	19	reduce	reduce	VERB
admet-557	207	20	the	the	DET
admet-557	207	21	large	large	ADJ
admet-557	207	22	number	number	NOUN
admet-557	207	23	of	of	ADP
admet-557	207	24	animal	animal	NOUN
admet-557	207	25	usage	usage	NOUN
admet-557	207	26	,	,	PUNCT
admet-557	207	27	allows	allow	VERB
admet-557	207	28	serial	serial	ADJ
admet-557	207	29	blood	blood	NOUN
admet-557	207	30	sampling	sample	VERB
admet-557	207	31	from	from	ADP
admet-557	207	32	mice	mouse	NOUN
admet-557	207	33	,	,	PUNCT
admet-557	207	34	useful	useful	ADJ
admet-557	207	35	in	in	ADP
admet-557	207	36	toxicokinetic	toxicokinetic	ADJ
admet-557	207	37	studies	study	NOUN
admet-557	207	38	etc	etc	X
admet-557	207	39	.	.	X
admet-557	208	1	further	far	ADV
admet-557	208	2	,	,	PUNCT
admet-557	208	3	blood	blood	NOUN
admet-557	208	4	samples	sample	NOUN
admet-557	208	5	having	have	VERB
admet-557	208	6	hematocrit	hematocrit	ADJ
admet-557	208	7	values	value	NOUN
admet-557	208	8	between	between	ADP
admet-557	208	9	25	25	NUM
admet-557	208	10	and	and	CCONJ
admet-557	208	11	45	45	NUM
admet-557	208	12	%	%	NOUN
admet-557	208	13	demonstrated	demonstrate	VERB
admet-557	208	14	acceptable	acceptable	ADJ
admet-557	208	15	accuracy	accuracy	NOUN
admet-557	208	16	and	and	CCONJ
admet-557	208	17	precision	precision	NOUN
admet-557	208	18	in	in	ADP
admet-557	208	19	the	the	DET
admet-557	208	20	quantitative	quantitative	ADJ
admet-557	208	21	measurements	measurement	NOUN
admet-557	208	22	.	.	PUNCT
admet-557	209	1	the	the	DET
admet-557	209	2	utility	utility	NOUN
admet-557	209	3	of	of	ADP
admet-557	209	4	this	this	DET
admet-557	209	5	assay	assay	NOUN
admet-557	209	6	was	be	AUX
admet-557	209	7	demonstrated	demonstrate	VERB
admet-557	209	8	through	through	ADP
admet-557	209	9	its	its	PRON
admet-557	209	10	successful	successful	ADJ
admet-557	209	11	application	application	NOUN
admet-557	209	12	to	to	ADP
admet-557	209	13	a	a	DET
admet-557	209	14	mice	mice	NOUN
admet-557	209	15	pharmacokinetic	pharmacokinetic	ADJ
admet-557	209	16	study	study	NOUN
admet-557	209	17	.	.	PUNCT
admet-557	210	1	conflict	conflict	NOUN
admet-557	210	2	of	of	ADP
admet-557	210	3	interest	interest	NOUN
admet-557	210	4	:	:	PUNCT
admet-557	210	5	the	the	DET
admet-557	210	6	authors	author	NOUN
admet-557	210	7	wish	wish	VERB
admet-557	210	8	to	to	PART
admet-557	210	9	declare	declare	VERB
admet-557	210	10	that	that	SCONJ
admet-557	210	11	there	there	PRON
admet-557	210	12	are	be	VERB
admet-557	210	13	no	no	DET
admet-557	210	14	conflicts	conflict	NOUN
admet-557	210	15	of	of	ADP
admet-557	210	16	interests	interest	NOUN
admet-557	210	17	in	in	ADP
admet-557	210	18	the	the	DET
admet-557	210	19	contents	content	NOUN
admet-557	210	20	of	of	ADP
admet-557	210	21	the	the	DET
admet-557	210	22	manuscript	manuscript	NOUN
admet-557	210	23	.	.	PUNCT
admet-557	211	1	references	reference	NOUN
admet-557	211	2	[	[	X
admet-557	211	3	1	1	NUM
admet-557	211	4	]	]	X
admet-557	211	5	r.l	r.l	PROPN
admet-557	211	6	.	.	PROPN
admet-557	211	7	siegel	siegel	PROPN
admet-557	211	8	,	,	PUNCT
admet-557	211	9	k.d	k.d	PROPN
admet-557	211	10	.	.	PROPN
admet-557	211	11	miller	miller	PROPN
admet-557	211	12	,	,	PUNCT
admet-557	211	13	a.	a.	PROPN
admet-557	211	14	jemal	jemal	PROPN
admet-557	211	15	.	.	PUNCT
admet-557	212	1	cancer	cancer	NOUN
admet-557	212	2	statistics	statistic	NOUN
admet-557	212	3	2017	2017	NUM
admet-557	212	4	.	.	PUNCT
admet-557	213	1	ca	ca	NOUN
admet-557	213	2	:	:	PUNCT
admet-557	213	3	a	a	DET
admet-557	213	4	cancer	cancer	NOUN
admet-557	213	5	journal	journal	NOUN
admet-557	213	6	for	for	ADP
admet-557	213	7	clinicians	clinician	NOUN
admet-557	213	8	67	67	NUM
admet-557	213	9	(	(	PUNCT
admet-557	213	10	2017	2017	NUM
admet-557	213	11	)	)	PUNCT
admet-557	213	12	7	7	NUM
admet-557	213	13	-	-	SYM
admet-557	213	14	30	30	NUM
admet-557	213	15	.	.	PUNCT
admet-557	214	1	[	[	X
admet-557	214	2	2	2	NUM
admet-557	214	3	]	]	X
admet-557	214	4	c.j	c.j	PROPN
admet-557	214	5	.	.	PROPN
admet-557	214	6	ryan	ryan	PROPN
admet-557	214	7	,	,	PUNCT
admet-557	214	8	m.l	m.l	PROPN
admet-557	214	9	.	.	PUNCT
admet-557	214	10	cheng	cheng	PROPN
admet-557	214	11	.	.	PUNCT
admet-557	215	1	abiraterone	abiraterone	NOUN
admet-557	215	2	acetate	acetate	NOUN
admet-557	215	3	for	for	ADP
admet-557	215	4	the	the	DET
admet-557	215	5	treatment	treatment	NOUN
admet-557	215	6	of	of	ADP
admet-557	215	7	prostate	prostate	NOUN
admet-557	215	8	cancer	cancer	NOUN
admet-557	215	9	.	.	PUNCT
admet-557	216	1	expert	expert	ADJ
admet-557	216	2	opinion	opinion	NOUN
admet-557	216	3	on	on	ADP
admet-557	216	4	pharmacotherapy	pharmacotherapy	NOUN
admet-557	216	5	14	14	NUM
admet-557	216	6	(	(	PUNCT
admet-557	216	7	2013	2013	NUM
admet-557	216	8	)	)	PUNCT
admet-557	216	9	91	91	NUM
admet-557	216	10	-	-	SYM
admet-557	216	11	96	96	NUM
admet-557	216	12	.	.	PUNCT
admet-557	217	1	r.	r.	PROPN
admet-557	217	2	mullangi	mullangi	VERB
admet-557	217	3	et	et	PROPN
admet-557	217	4	al	al	PROPN
admet-557	217	5	.	.	PROPN
admet-557	217	6	admet	admet	PROPN
admet-557	217	7	&	&	CCONJ
admet-557	217	8	dmpk	dmpk	PROPN
admet-557	217	9	6(3	6(3	PROPN
admet-557	217	10	)	)	PUNCT
admet-557	217	11	(	(	PUNCT
admet-557	217	12	2018	2018	NUM
admet-557	217	13	)	)	PUNCT
admet-557	217	14	242	242	NUM
admet-557	217	15	-	-	SYM
admet-557	217	16	257	257	NUM
admet-557	217	17	256	256	NUM
admet-557	217	18	[	[	SYM
admet-557	217	19	3	3	NUM
admet-557	217	20	]	]	X
admet-557	217	21	h.i	h.i	PROPN
admet-557	217	22	.	.	PROPN
admet-557	217	23	scher	scher	PROPN
admet-557	217	24	,	,	PUNCT
admet-557	217	25	c.l	c.l	PROPN
admet-557	217	26	.	.	PROPN
admet-557	217	27	sawyers	sawyer	NOUN
admet-557	217	28	.	.	PUNCT
admet-557	218	1	biology	biology	NOUN
admet-557	218	2	of	of	ADP
admet-557	218	3	progressive	progressive	ADJ
admet-557	218	4	,	,	PUNCT
admet-557	218	5	castration	castration	NOUN
admet-557	218	6	-	-	PUNCT
admet-557	218	7	resistant	resistant	ADJ
admet-557	218	8	prostate	prostate	NOUN
admet-557	218	9	cancer	cancer	NOUN
admet-557	218	10	:	:	PUNCT
admet-557	218	11	directed	direct	VERB
admet-557	218	12	therapies	therapy	NOUN
admet-557	218	13	targeting	target	VERB
admet-557	218	14	the	the	DET
admet-557	218	15	androgen	androgen	NOUN
admet-557	218	16	-	-	PUNCT
admet-557	218	17	receptor	receptor	NOUN
admet-557	218	18	signaling	signal	VERB
admet-557	218	19	axis	axis	NOUN
admet-557	218	20	.	.	PUNCT
admet-557	219	1	journal	journal	NOUN
admet-557	219	2	of	of	ADP
admet-557	219	3	clinical	clinical	ADJ
admet-557	219	4	oncology	oncology	NOUN
admet-557	219	5	23	23	NUM
admet-557	219	6	(	(	PUNCT
admet-557	219	7	2005	2005	NUM
admet-557	219	8	)	)	PUNCT
admet-557	219	9	8253	8253	NUM
admet-557	219	10	-	-	SYM
admet-557	219	11	8261	8261	NUM
admet-557	219	12	.	.	PUNCT
admet-557	220	1	[	[	X
admet-557	220	2	4	4	NUM
admet-557	220	3	]	]	X
admet-557	220	4	l.j	l.j	PROPN
admet-557	220	5	.	.	PROPN
admet-557	220	6	scott	scott	PROPN
admet-557	220	7	.	.	PUNCT
admet-557	221	1	abiraterone	abiraterone	NOUN
admet-557	221	2	acetate	acetate	NOUN
admet-557	221	3	:	:	PUNCT
admet-557	221	4	a	a	DET
admet-557	221	5	review	review	NOUN
admet-557	221	6	in	in	ADP
admet-557	221	7	metastatic	metastatic	ADJ
admet-557	221	8	castration	castration	NOUN
admet-557	221	9	-	-	PUNCT
admet-557	221	10	resistant	resistant	ADJ
admet-557	221	11	prostate	prostate	NOUN
admet-557	221	12	cancer	cancer	NOUN
admet-557	221	13	.	.	PUNCT
admet-557	222	1	drugs	drug	NOUN
admet-557	222	2	77	77	NUM
admet-557	222	3	(	(	PUNCT
admet-557	222	4	2017	2017	NUM
admet-557	222	5	)	)	PUNCT
admet-557	222	6	1565	1565	NUM
admet-557	222	7	-	-	SYM
admet-557	222	8	1576	1576	NUM
admet-557	222	9	.	.	PUNCT
admet-557	223	1	[	[	X
admet-557	223	2	5	5	NUM
admet-557	223	3	]	]	PUNCT
admet-557	223	4	a.	a.	NOUN
admet-557	223	5	mullard	mullard	PROPN
admet-557	223	6	.	.	PUNCT
admet-557	224	1	2012	2012	NUM
admet-557	224	2	fda	fda	PROPN
admet-557	224	3	drug	drug	NOUN
admet-557	224	4	approvals	approval	NOUN
admet-557	224	5	.	.	PUNCT
admet-557	225	1	nature	nature	NOUN
admet-557	225	2	reviews	review	VERB
admet-557	225	3	drug	drug	NOUN
admet-557	225	4	discovery	discovery	NOUN
admet-557	225	5	12	12	NUM
admet-557	225	6	(	(	PUNCT
admet-557	225	7	2013	2013	NUM
admet-557	225	8	)	)	PUNCT
admet-557	225	9	87	87	NUM
admet-557	225	10	-	-	SYM
admet-557	225	11	90	90	NUM
admet-557	225	12	.	.	PUNCT
admet-557	226	1	[	[	X
admet-557	226	2	6	6	NUM
admet-557	226	3	]	]	X
admet-557	226	4	z.t	z.t	PROPN
admet-557	226	5	.	.	PUNCT
admet-557	226	6	al	al	PROPN
admet-557	226	7	-	-	PUNCT
admet-557	226	8	salama	salama	NOUN
admet-557	226	9	.	.	PUNCT
admet-557	227	1	apalutamide	apalutamide	ADV
admet-557	227	2	:	:	PUNCT
admet-557	227	3	first	first	PROPN
admet-557	227	4	global	global	ADJ
admet-557	227	5	approval	approval	NOUN
admet-557	227	6	.	.	PUNCT
admet-557	228	1	drugs	drug	NOUN
admet-557	228	2	78	78	NUM
admet-557	228	3	(	(	PUNCT
admet-557	228	4	2018	2018	NUM
admet-557	228	5	)	)	PUNCT
admet-557	228	6	699	699	NUM
admet-557	228	7	-	-	SYM
admet-557	228	8	705	705	NUM
admet-557	228	9	.	.	PUNCT
admet-557	229	1	[	[	X
admet-557	229	2	7	7	X
admet-557	229	3	]	]	PUNCT
admet-557	229	4	a.m.	a.m.	NOUN
admet-557	229	5	moilanen	moilanen	PROPN
admet-557	229	6	,	,	PUNCT
admet-557	229	7	r.	r.	PROPN
admet-557	229	8	riikonen	riikonen	PROPN
admet-557	229	9	,	,	PUNCT
admet-557	229	10	r.	r.	PROPN
admet-557	229	11	oksala	oksala	PROPN
admet-557	229	12	,	,	PUNCT
admet-557	229	13	l.	l.	PROPN
admet-557	229	14	ravanti	ravanti	PROPN
admet-557	229	15	,	,	PUNCT
admet-557	229	16	e.	e.	PROPN
admet-557	229	17	aho	aho	PROPN
admet-557	229	18	,	,	PUNCT
admet-557	229	19	g.	g.	PROPN
admet-557	229	20	wohlfahrt	wohlfahrt	PROPN
admet-557	229	21	,	,	PUNCT
admet-557	229	22	p.s	p.s	PROPN
admet-557	229	23	.	.	PROPN
admet-557	229	24	nykänen	nykänen	PROPN
admet-557	229	25	,	,	PUNCT
admet-557	229	26	o.p	o.p	PROPN
admet-557	229	27	.	.	PROPN
admet-557	229	28	törmäkangas	törmäkangas	PROPN
admet-557	229	29	,	,	PUNCT
admet-557	229	30	j.j	j.j	PROPN
admet-557	229	31	.	.	PROPN
admet-557	229	32	palvimo	palvimo	PROPN
admet-557	229	33	,	,	PUNCT
admet-557	229	34	p.j	p.j	PROPN
admet-557	229	35	.	.	PROPN
admet-557	229	36	kallio	kallio	PROPN
admet-557	229	37	.	.	PUNCT
admet-557	230	1	discovery	discovery	NOUN
admet-557	230	2	of	of	ADP
admet-557	230	3	odm-201	odm-201	NOUN
admet-557	230	4	,	,	PUNCT
admet-557	230	5	a	a	DET
admet-557	230	6	new	new	ADJ
admet-557	230	7	-	-	PUNCT
admet-557	230	8	generation	generation	NOUN
admet-557	230	9	androgen	androgen	NOUN
admet-557	230	10	receptor	receptor	NOUN
admet-557	230	11	inhibitor	inhibitor	NOUN
admet-557	230	12	targeting	target	VERB
admet-557	230	13	resistance	resistance	NOUN
admet-557	230	14	mechanisms	mechanism	NOUN
admet-557	230	15	to	to	ADP
admet-557	230	16	androgen	androgen	NOUN
admet-557	230	17	signaling	signal	VERB
admet-557	230	18	-	-	PUNCT
admet-557	230	19	directed	direct	VERB
admet-557	230	20	prostate	prostate	NOUN
admet-557	230	21	cancer	cancer	NOUN
admet-557	230	22	therapies	therapy	NOUN
admet-557	230	23	.	.	PUNCT
admet-557	231	1	scientific	scientific	ADJ
admet-557	231	2	reports	report	NOUN
admet-557	231	3	5	5	NUM
admet-557	231	4	(	(	PUNCT
admet-557	231	5	2017	2017	NUM
admet-557	231	6	)	)	PUNCT
admet-557	231	7	12007	12007	NUM
admet-557	231	8	.	.	PUNCT
admet-557	232	1	[	[	X
admet-557	232	2	8	8	X
admet-557	232	3	]	]	X
admet-557	232	4	j.	j.	PROPN
admet-557	232	5	semenas	semenas	PROPN
admet-557	232	6	,	,	PUNCT
admet-557	232	7	n.	n.	PROPN
admet-557	232	8	dizeyi	dizeyi	PROPN
admet-557	232	9	,	,	PUNCT
admet-557	232	10	j.l	j.l	PROPN
admet-557	232	11	.	.	PROPN
admet-557	232	12	persson	persson	PROPN
admet-557	232	13	.	.	PUNCT
admet-557	233	1	enzalutamide	enzalutamide	ADV
admet-557	233	2	as	as	ADP
admet-557	233	3	a	a	DET
admet-557	233	4	second	second	ADJ
admet-557	233	5	generation	generation	NOUN
admet-557	233	6	antiandrogen	antiandrogen	NOUN
admet-557	233	7	for	for	ADP
admet-557	233	8	treatment	treatment	NOUN
admet-557	233	9	of	of	ADP
admet-557	233	10	advanced	advanced	ADJ
admet-557	233	11	prostate	prostate	NOUN
admet-557	233	12	cancer	cancer	NOUN
admet-557	233	13	.	.	PUNCT
admet-557	234	1	drug	drug	NOUN
admet-557	234	2	design	design	NOUN
admet-557	234	3	development	development	NOUN
admet-557	234	4	and	and	CCONJ
admet-557	234	5	therapy	therapy	NOUN
admet-557	234	6	7	7	NUM
admet-557	234	7	(	(	PUNCT
admet-557	234	8	2013	2013	NUM
admet-557	234	9	)	)	PUNCT
admet-557	234	10	875	875	NUM
admet-557	234	11	-	-	SYM
admet-557	234	12	881	881	NUM
admet-557	234	13	.	.	PUNCT
admet-557	235	1	[	[	X
admet-557	235	2	9	9	NUM
admet-557	235	3	]	]	X
admet-557	235	4	j.a	j.a	PROPN
admet-557	235	5	.	.	PROPN
admet-557	235	6	gibbons	gibbon	NOUN
admet-557	235	7	,	,	PUNCT
admet-557	235	8	t.	t.	NOUN
admet-557	235	9	ouatas	ouata	NOUN
admet-557	235	10	,	,	PUNCT
admet-557	235	11	w.	w.	PROPN
admet-557	235	12	krauwinkel	krauwinkel	PROPN
admet-557	235	13	,	,	PUNCT
admet-557	235	14	y.	y.	PROPN
admet-557	235	15	ohtsu	ohtsu	PROPN
admet-557	235	16	,	,	PUNCT
admet-557	235	17	j.s	j.s	PROPN
admet-557	235	18	.	.	PROPN
admet-557	235	19	van	van	PROPN
admet-557	235	20	der	der	PROPN
admet-557	235	21	walt	walt	PROPN
admet-557	235	22	,	,	PUNCT
admet-557	235	23	v.	v.	ADP
admet-557	235	24	beddo	beddo	NOUN
admet-557	235	25	,	,	PUNCT
admet-557	235	26	m.	m.	NOUN
admet-557	235	27	de	de	PROPN
admet-557	235	28	vries	vries	PROPN
admet-557	235	29	,	,	PUNCT
admet-557	235	30	j.	j.	PROPN
admet-557	235	31	mordenti	mordenti	PROPN
admet-557	235	32	.	.	PUNCT
admet-557	236	1	clinical	clinical	ADJ
admet-557	236	2	pharmacokinetic	pharmacokinetic	ADJ
admet-557	236	3	studies	study	NOUN
admet-557	236	4	of	of	ADP
admet-557	236	5	enzalutamide	enzalutamide	NOUN
admet-557	236	6	.	.	PUNCT
admet-557	237	1	clinical	clinical	ADJ
admet-557	237	2	pharmacokinetics	pharmacokinetic	NOUN
admet-557	237	3	54	54	NUM
admet-557	237	4	(	(	PUNCT
admet-557	237	5	2015	2015	NUM
admet-557	237	6	)	)	PUNCT
admet-557	237	7	1043	1043	NUM
admet-557	237	8	-	-	SYM
admet-557	237	9	1055	1055	NUM
admet-557	237	10	.	.	PUNCT
admet-557	238	1	[	[	X
admet-557	238	2	10	10	NUM
admet-557	238	3	]	]	PUNCT
admet-557	238	4	j.	j.	PROPN
admet-557	238	5	weiss	weiss	PROPN
admet-557	238	6	,	,	PUNCT
admet-557	238	7	j.	j.	PROPN
admet-557	238	8	kocher	kocher	PROPN
admet-557	238	9	,	,	PUNCT
admet-557	238	10	c.	c.	PROPN
admet-557	238	11	mueller	mueller	PROPN
admet-557	238	12	,	,	PUNCT
admet-557	238	13	s.	s.	PROPN
admet-557	238	14	rosenzweig	rosenzweig	PROPN
admet-557	238	15	,	,	PUNCT
admet-557	238	16	d.	d.	PROPN
admet-557	238	17	theile	theile	NOUN
admet-557	238	18	.	.	PUNCT
admet-557	239	1	impact	impact	NOUN
admet-557	239	2	of	of	ADP
admet-557	239	3	enzalutamide	enzalutamide	NOUN
admet-557	239	4	and	and	CCONJ
admet-557	239	5	its	its	PRON
admet-557	239	6	main	main	ADJ
admet-557	239	7	metabolite	metabolite	NOUN
admet-557	239	8	n	n	CCONJ
admet-557	239	9	-	-	PUNCT
admet-557	239	10	desmethylenzalutamide	desmethylenzalutamide	VERB
admet-557	239	11	on	on	ADP
admet-557	239	12	pharmacokinetically	pharmacokinetically	ADV
admet-557	239	13	important	important	ADJ
admet-557	239	14	drug	drug	NOUN
admet-557	239	15	metabolizing	metabolize	VERB
admet-557	239	16	enzymes	enzyme	NOUN
admet-557	239	17	and	and	CCONJ
admet-557	239	18	drug	drug	NOUN
admet-557	239	19	transporters	transporter	NOUN
admet-557	239	20	.	.	PUNCT
admet-557	240	1	biopharmaceutics	biopharmaceutics	PROPN
admet-557	240	2	&	&	CCONJ
admet-557	240	3	drug	drug	PROPN
admet-557	240	4	disposition	disposition	NOUN
admet-557	240	5	38	38	NUM
admet-557	240	6	(	(	PUNCT
admet-557	240	7	2017	2017	NUM
admet-557	240	8	)	)	PUNCT
admet-557	240	9	517	517	NUM
admet-557	240	10	-	-	SYM
admet-557	240	11	525	525	NUM
admet-557	240	12	.	.	PUNCT
admet-557	241	1	[	[	X
admet-557	241	2	11	11	NUM
admet-557	241	3	]	]	PUNCT
admet-557	241	4	k.	k.	PROPN
admet-557	241	5	fizazi	fizazi	PROPN
admet-557	241	6	,	,	PUNCT
admet-557	241	7	c.	c.	PROPN
admet-557	241	8	massard	massard	PROPN
admet-557	241	9	,	,	PUNCT
admet-557	241	10	n.d	n.d	PROPN
admet-557	241	11	.	.	PROPN
admet-557	241	12	james	james	PROPN
admet-557	242	1	.	.	PROPN
admet-557	242	2	odm-201	odm-201	PROPN
admet-557	242	3	,	,	PUNCT
admet-557	242	4	a	a	DET
admet-557	242	5	new	new	ADJ
admet-557	242	6	generation	generation	NOUN
admet-557	242	7	androgen	androgen	NOUN
admet-557	242	8	receptor	receptor	NOUN
admet-557	242	9	inhibitor	inhibitor	NOUN
admet-557	242	10	for	for	ADP
admet-557	242	11	castration	castration	NOUN
admet-557	242	12	-	-	PUNCT
admet-557	242	13	resistant	resistant	ADJ
admet-557	242	14	prostate	prostate	NOUN
admet-557	242	15	cancer	cancer	NOUN
admet-557	242	16	:	:	PUNCT
admet-557	242	17	preclinical	preclinical	ADJ
admet-557	242	18	and	and	CCONJ
admet-557	242	19	phase	phase	NOUN
admet-557	242	20	i	i	PRON
admet-557	242	21	data	data	VERB
admet-557	242	22	.	.	PUNCT
admet-557	243	1	american	american	ADJ
admet-557	243	2	society	society	NOUN
admet-557	243	3	of	of	ADP
admet-557	243	4	clinical	clinical	ADJ
admet-557	243	5	oncology	oncology	NOUN
admet-557	243	6	journal	journal	NOUN
admet-557	243	7	31	31	NUM
admet-557	243	8	(	(	PUNCT
admet-557	243	9	suppl	suppl	PROPN
admet-557	243	10	6	6	NUM
admet-557	243	11	)	)	PUNCT
admet-557	243	12	(	(	PUNCT
admet-557	243	13	2013	2013	NUM
admet-557	243	14	)	)	PUNCT
admet-557	243	15	abstract	abstract	NOUN
admet-557	243	16	65	65	NUM
admet-557	243	17	.	.	PUNCT
admet-557	244	1	[	[	X
admet-557	244	2	12	12	NUM
admet-557	244	3	]	]	PUNCT
admet-557	244	4	a.	a.	NOUN
admet-557	244	5	moilanen	moilanen	PROPN
admet-557	244	6	,	,	PUNCT
admet-557	244	7	r.	r.	PROPN
admet-557	244	8	riikonen	riikonen	PROPN
admet-557	244	9	,	,	PUNCT
admet-557	244	10	r.	r.	PROPN
admet-557	244	11	oksala	oksala	PROPN
admet-557	244	12	.	.	PUNCT
admet-557	245	1	odm-201	odm-201	PROPN
admet-557	245	2	new	new	ADJ
admet-557	245	3	generation	generation	NOUN
admet-557	245	4	antiandrogen	antiandrogen	NOUN
admet-557	245	5	with	with	ADP
admet-557	245	6	excellent	excellent	ADJ
admet-557	245	7	antiandrogenic	antiandrogenic	ADJ
admet-557	245	8	and	and	CCONJ
admet-557	245	9	antitumor	antitumor	PROPN
admet-557	245	10	activity	activity	NOUN
admet-557	245	11	in	in	ADP
admet-557	245	12	nonclinical	nonclinical	ADJ
admet-557	245	13	models	model	NOUN
admet-557	245	14	of	of	ADP
admet-557	245	15	crpc	crpc	ADJ
admet-557	245	16	.	.	PUNCT
admet-557	246	1	european	european	PROPN
admet-557	246	2	journal	journal	PROPN
admet-557	246	3	of	of	ADP
admet-557	246	4	cancer	cancer	NOUN
admet-557	246	5	49	49	NUM
admet-557	246	6	(	(	PUNCT
admet-557	246	7	suppl	suppl	NOUN
admet-557	246	8	2	2	NUM
admet-557	246	9	)	)	PUNCT
admet-557	246	10	(	(	PUNCT
admet-557	246	11	2013	2013	NUM
admet-557	246	12	)	)	PUNCT
admet-557	246	13	abstract	abstract	ADJ
admet-557	246	14	685	685	NUM
admet-557	246	15	.	.	PUNCT
admet-557	247	1	[	[	X
admet-557	247	2	13	13	NUM
admet-557	247	3	]	]	SYM
admet-557	247	4	orion	orion	NOUN
admet-557	247	5	pharma	pharma	PROPN
admet-557	247	6	clinical	clinical	ADJ
admet-557	247	7	study	study	NOUN
admet-557	247	8	code	code	NOUN
admet-557	247	9	:	:	PUNCT
admet-557	247	10	3104001	3104001	NUM
admet-557	247	11	/	/	SYM
admet-557	247	12	en3386	en3386	VERB
admet-557	247	13	-	-	PUNCT
admet-557	247	14	201	201	NUM
admet-557	247	15	(	(	PUNCT
admet-557	247	16	accessed	access	VERB
admet-557	247	17	on	on	ADP
admet-557	247	18	7	7	NUM
admet-557	247	19	june	june	PROPN
admet-557	247	20	2018	2018	NUM
admet-557	247	21	)	)	PUNCT
admet-557	247	22	.	.	PUNCT
admet-557	248	1	[	[	X
admet-557	248	2	14	14	NUM
admet-557	248	3	]	]	X
admet-557	248	4	j.h	j.h	PROPN
admet-557	248	5	.	.	PROPN
admet-557	248	6	song	song	PROPN
admet-557	248	7	,	,	PUNCT
admet-557	248	8	t.h	t.h	PROPN
admet-557	248	9	.	.	PROPN
admet-557	248	10	kim	kim	PROPN
admet-557	248	11	,	,	PUNCT
admet-557	248	12	j.w	j.w	PROPN
admet-557	248	13	.	.	PROPN
admet-557	248	14	jung	jung	PROPN
admet-557	248	15	,	,	PUNCT
admet-557	248	16	n.	n.	PROPN
admet-557	248	17	kim	kim	PROPN
admet-557	248	18	,	,	PUNCT
admet-557	248	19	s.h	s.h	PROPN
admet-557	248	20	.	.	PROPN
admet-557	248	21	ahn	ahn	PROPN
admet-557	248	22	,	,	PUNCT
admet-557	248	23	s.o	s.o	PROPN
admet-557	248	24	.	.	PROPN
admet-557	248	25	hwang	hwang	PROPN
admet-557	248	26	,	,	PUNCT
admet-557	248	27	n.s	n.s	PROPN
admet-557	248	28	.	.	PROPN
admet-557	248	29	kang	kang	PROPN
admet-557	248	30	,	,	PUNCT
admet-557	248	31	s.w	s.w	PROPN
admet-557	248	32	.	.	PROPN
admet-557	248	33	yoo	yoo	PROPN
admet-557	248	34	,	,	PUNCT
admet-557	248	35	t.s	t.s	PROPN
admet-557	248	36	.	.	PROPN
admet-557	248	37	koo	koo	PROPN
admet-557	248	38	.	.	PUNCT
admet-557	249	1	quantitative	quantitative	ADJ
admet-557	249	2	determination	determination	NOUN
admet-557	249	3	of	of	ADP
admet-557	249	4	enzalutamide	enzalutamide	NOUN
admet-557	249	5	,	,	PUNCT
admet-557	249	6	an	an	DET
admet-557	249	7	anti	anti	ADJ
admet-557	249	8	-	-	ADJ
admet-557	249	9	prostate	prostate	ADJ
admet-557	249	10	cancer	cancer	NOUN
admet-557	249	11	drug	drug	NOUN
admet-557	249	12	,	,	PUNCT
admet-557	249	13	in	in	ADP
admet-557	249	14	rat	rat	NOUN
admet-557	249	15	plasma	plasma	NOUN
admet-557	249	16	using	use	VERB
admet-557	249	17	liquid	liquid	ADJ
admet-557	249	18	chromatography	chromatography	NOUN
admet-557	249	19	-	-	PUNCT
admet-557	249	20	tandem	tandem	NOUN
admet-557	249	21	mass	mass	PROPN
admet-557	249	22	spectrometry	spectrometry	NOUN
admet-557	249	23	,	,	PUNCT
admet-557	249	24	and	and	CCONJ
admet-557	249	25	its	its	PRON
admet-557	249	26	application	application	NOUN
admet-557	249	27	to	to	ADP
admet-557	249	28	a	a	DET
admet-557	249	29	pharmacokinetic	pharmacokinetic	ADJ
admet-557	249	30	study	study	NOUN
admet-557	249	31	.	.	PUNCT
admet-557	250	1	biomedical	biomedical	ADJ
admet-557	250	2	chromatography	chromatography	NOUN
admet-557	250	3	28	28	NUM
admet-557	250	4	(	(	PUNCT
admet-557	250	5	2014	2014	NUM
admet-557	250	6	)	)	PUNCT
admet-557	250	7	1112	1112	NUM
admet-557	250	8	-	-	SYM
admet-557	250	9	1117	1117	NUM
admet-557	250	10	.	.	PUNCT
admet-557	251	1	[	[	X
admet-557	251	2	15	15	NUM
admet-557	251	3	]	]	X
admet-557	251	4	s.	s.	PROPN
admet-557	251	5	bennett	bennett	PROPN
admet-557	251	6	,	,	PUNCT
admet-557	251	7	j.a	j.a	PROPN
admet-557	251	8	.	.	PROPN
admet-557	251	9	gibbons	gibbon	NOUN
admet-557	251	10	,	,	PUNCT
admet-557	251	11	r.	r.	PROPN
admet-557	251	12	mol	mol	PROPN
admet-557	251	13	,	,	PUNCT
admet-557	251	14	y.	y.	PROPN
admet-557	251	15	ohtsu	ohtsu	PROPN
admet-557	251	16	,	,	PUNCT
admet-557	251	17	c.	c.	PROPN
admet-557	251	18	williard	williard	PROPN
admet-557	251	19	.	.	PUNCT
admet-557	252	1	validation	validation	NOUN
admet-557	252	2	of	of	ADP
admet-557	252	3	a	a	DET
admet-557	252	4	method	method	NOUN
admet-557	252	5	for	for	ADP
admet-557	252	6	quantifying	quantify	VERB
admet-557	252	7	enzalutamide	enzalutamide	ADV
admet-557	252	8	and	and	CCONJ
admet-557	252	9	its	its	PRON
admet-557	252	10	major	major	ADJ
admet-557	252	11	metabolites	metabolite	NOUN
admet-557	252	12	in	in	ADP
admet-557	252	13	human	human	ADJ
admet-557	252	14	plasma	plasma	NOUN
admet-557	252	15	by	by	ADP
admet-557	252	16	lc	lc	PROPN
admet-557	252	17	-	-	PUNCT
admet-557	252	18	ms	ms	PROPN
admet-557	252	19	/	/	SYM
admet-557	252	20	ms	ms	PROPN
admet-557	252	21	.	.	PROPN
admet-557	252	22	bioanalysis	bioanalysis	PROPN
admet-557	252	23	6	6	NUM
admet-557	252	24	(	(	PUNCT
admet-557	252	25	2014	2014	NUM
admet-557	252	26	)	)	PUNCT
admet-557	252	27	737744	737744	NUM
admet-557	252	28	.	.	PUNCT
admet-557	253	1	[	[	X
admet-557	253	2	16	16	NUM
admet-557	253	3	]	]	X
admet-557	253	4	y.	y.	PROPN
admet-557	253	5	ohtsu	ohtsu	PROPN
admet-557	253	6	,	,	PUNCT
admet-557	253	7	d.r	d.r	PROPN
admet-557	253	8	.	.	PROPN
admet-557	253	9	thakker	thakker	PROPN
admet-557	253	10	,	,	PUNCT
admet-557	253	11	j.a	j.a	PROPN
admet-557	253	12	.	.	PROPN
admet-557	253	13	gibbons	gibbon	NOUN
admet-557	253	14	,	,	PUNCT
admet-557	253	15	k.	k.	PROPN
admet-557	253	16	tsubota	tsubota	PROPN
admet-557	253	17	,	,	PUNCT
admet-557	253	18	s.	s.	PROPN
admet-557	253	19	otsuka	otsuka	PROPN
admet-557	253	20	,	,	PUNCT
admet-557	253	21	h.	h.	PROPN
admet-557	253	22	arai	arai	PROPN
admet-557	253	23	.	.	PUNCT
admet-557	254	1	determination	determination	NOUN
admet-557	254	2	of	of	ADP
admet-557	254	3	the	the	DET
admet-557	254	4	androgen	androgen	NOUN
admet-557	254	5	receptor	receptor	NOUN
admet-557	254	6	inhibitor	inhibitor	NOUN
admet-557	254	7	enzalutamide	enzalutamide	ADV
admet-557	254	8	and	and	CCONJ
admet-557	254	9	its	its	PRON
admet-557	254	10	metabolites	metabolite	NOUN
admet-557	254	11	in	in	ADP
admet-557	254	12	animal	animal	NOUN
admet-557	254	13	plasma	plasma	NOUN
admet-557	254	14	and	and	CCONJ
admet-557	254	15	brain	brain	NOUN
admet-557	254	16	homogenates	homogenate	NOUN
admet-557	254	17	using	use	VERB
admet-557	254	18	lc	lc	PROPN
admet-557	254	19	-	-	PUNCT
admet-557	254	20	ms	ms	PROPN
admet-557	254	21	/	/	SYM
admet-557	254	22	ms	ms	PROPN
admet-557	254	23	and	and	CCONJ
admet-557	254	24	its	its	PRON
admet-557	254	25	application	application	NOUN
admet-557	254	26	to	to	ADP
admet-557	254	27	pharmacokinetic	pharmacokinetic	ADJ
admet-557	254	28	studies	study	NOUN
admet-557	254	29	.	.	PUNCT
admet-557	255	1	chromatography	chromatography	NOUN
admet-557	255	2	36	36	NUM
admet-557	255	3	(	(	PUNCT
admet-557	255	4	2015	2015	NUM
admet-557	255	5	)	)	PUNCT
admet-557	255	6	115	115	NUM
admet-557	255	7	-	-	SYM
admet-557	255	8	122	122	NUM
admet-557	255	9	.	.	PUNCT
admet-557	256	1	[	[	X
admet-557	256	2	17	17	NUM
admet-557	256	3	]	]	X
admet-557	256	4	k.p	k.p	PROPN
admet-557	256	5	.	.	PROPN
admet-557	256	6	kim	kim	PROPN
admet-557	256	7	,	,	PUNCT
admet-557	256	8	r.a	r.a	PROPN
admet-557	256	9	.	.	PROPN
admet-557	256	10	parise	parise	PROPN
admet-557	256	11	,	,	PUNCT
admet-557	256	12	j.l	j.l	PROPN
admet-557	256	13	.	.	PROPN
admet-557	256	14	holleran	holleran	PROPN
admet-557	256	15	,	,	PUNCT
admet-557	256	16	l.d	l.d	PROPN
admet-557	256	17	.	.	PROPN
admet-557	256	18	lewis	lewis	PROPN
admet-557	256	19	,	,	PUNCT
admet-557	256	20	l.	l.	PROPN
admet-557	256	21	appleman	appleman	PROPN
admet-557	256	22	,	,	PUNCT
admet-557	256	23	n.	n.	PROPN
admet-557	256	24	van	van	PROPN
admet-557	256	25	erp	erp	PROPN
admet-557	256	26	,	,	PUNCT
admet-557	256	27	m.j	m.j	PROPN
admet-557	256	28	.	.	PROPN
admet-557	256	29	morris	morris	PROPN
admet-557	256	30	,	,	PUNCT
admet-557	256	31	j.h	j.h	PROPN
admet-557	256	32	.	.	PROPN
admet-557	256	33	beumer	beumer	NOUN
admet-557	256	34	.	.	PUNCT
admet-557	257	1	simultaneous	simultaneous	ADJ
admet-557	257	2	quantitation	quantitation	NOUN
admet-557	257	3	of	of	ADP
admet-557	257	4	abiraterone	abiraterone	NOUN
admet-557	257	5	,	,	PUNCT
admet-557	257	6	enzalutamide	enzalutamide	ADJ
admet-557	257	7	,	,	PUNCT
admet-557	257	8	n	n	CCONJ
admet-557	257	9	-	-	PUNCT
admet-557	257	10	desmethylenzalutamide	desmethylenzalutamide	NOUN
admet-557	257	11	,	,	PUNCT
admet-557	257	12	and	and	CCONJ
admet-557	257	13	bicalutamide	bicalutamide	VERB
admet-557	257	14	in	in	ADP
admet-557	257	15	human	human	ADJ
admet-557	257	16	plasma	plasma	NOUN
admet-557	257	17	by	by	ADP
admet-557	257	18	lc	lc	PROPN
admet-557	257	19	-	-	PUNCT
admet-557	257	20	ms	ms	PROPN
admet-557	257	21	/	/	SYM
admet-557	257	22	ms	ms	PROPN
admet-557	257	23	.	.	PROPN
admet-557	257	24	journal	journal	PROPN
admet-557	257	25	of	of	ADP
admet-557	257	26	pharmaceutical	pharmaceutical	NOUN
admet-557	257	27	and	and	CCONJ
admet-557	257	28	biomedical	biomedical	ADJ
admet-557	257	29	analysis	analysis	NOUN
admet-557	257	30	138	138	NUM
admet-557	257	31	(	(	PUNCT
admet-557	257	32	2017	2017	NUM
admet-557	257	33	)	)	PUNCT
admet-557	257	34	197	197	NUM
admet-557	257	35	-	-	SYM
admet-557	257	36	205	205	NUM
admet-557	257	37	.	.	PUNCT
admet-557	258	1	[	[	X
admet-557	258	2	18	18	NUM
admet-557	258	3	]	]	PUNCT
admet-557	258	4	m.	m.	NOUN
admet-557	258	5	van	van	PROPN
admet-557	258	6	nuland	nuland	ADV
admet-557	258	7	,	,	PUNCT
admet-557	258	8	m.j.x	m.j.x	PROPN
admet-557	258	9	.	.	PUNCT
admet-557	258	10	hillebrand	hillebrand	PROPN
admet-557	258	11	,	,	PUNCT
admet-557	258	12	h.	h.	PROPN
admet-557	258	13	rosing	rosing	PROPN
admet-557	258	14	,	,	PUNCT
admet-557	258	15	j.h.m	j.h.m	PROPN
admet-557	258	16	.	.	PUNCT
admet-557	258	17	schellens	schellens	PROPN
admet-557	258	18	,	,	PUNCT
admet-557	258	19	j.h	j.h	PROPN
admet-557	258	20	.	.	PROPN
admet-557	258	21	beijnen	beijnen	PROPN
admet-557	258	22	.	.	PUNCT
admet-557	259	1	development	development	NOUN
admet-557	259	2	and	and	CCONJ
admet-557	259	3	validation	validation	NOUN
admet-557	259	4	of	of	ADP
admet-557	259	5	an	an	DET
admet-557	259	6	lc	lc	NOUN
admet-557	259	7	-	-	PUNCT
admet-557	259	8	ms	ms	PROPN
admet-557	259	9	/	/	SYM
admet-557	259	10	ms	ms	PROPN
admet-557	259	11	method	method	NOUN
admet-557	259	12	for	for	ADP
admet-557	259	13	the	the	DET
admet-557	259	14	simultaneous	simultaneous	ADJ
admet-557	259	15	quantification	quantification	NOUN
admet-557	259	16	of	of	ADP
admet-557	259	17	abiraterone	abiraterone	NOUN
admet-557	259	18	,	,	PUNCT
admet-557	259	19	enzalutamide	enzalutamide	ADV
admet-557	259	20	,	,	PUNCT
admet-557	259	21	and	and	CCONJ
admet-557	259	22	their	their	PRON
admet-557	259	23	major	major	ADJ
admet-557	259	24	metabolites	metabolite	NOUN
admet-557	259	25	in	in	ADP
admet-557	259	26	human	human	ADJ
admet-557	259	27	plasma	plasma	NOUN
admet-557	259	28	.	.	PUNCT
admet-557	260	1	therapeutic	therapeutic	ADJ
admet-557	260	2	drug	drug	NOUN
admet-557	260	3	monitoring	monitor	VERB
admet-557	260	4	39	39	NUM
admet-557	260	5	(	(	PUNCT
admet-557	260	6	2017	2017	NUM
admet-557	260	7	)	)	PUNCT
admet-557	260	8	243	243	NUM
admet-557	260	9	-	-	SYM
admet-557	260	10	251	251	NUM
admet-557	260	11	.	.	PUNCT
admet-557	261	1	[	[	X
admet-557	261	2	19	19	NUM
admet-557	261	3	]	]	SYM
admet-557	261	4	s.p	s.p	PROPN
admet-557	261	5	.	.	PROPN
admet-557	261	6	sulochana	sulochana	PROPN
admet-557	261	7	,	,	PUNCT
admet-557	261	8	n.k	n.k	PROPN
admet-557	261	9	.	.	PROPN
admet-557	261	10	saini	saini	PROPN
admet-557	261	11	,	,	PUNCT
admet-557	261	12	p.	p.	PROPN
admet-557	261	13	daram	daram	PROPN
admet-557	261	14	,	,	PUNCT
admet-557	261	15	p.s	p.s	PROPN
admet-557	261	16	.	.	PUNCT
admet-557	261	17	babu	babu	PROPN
admet-557	261	18	,	,	PUNCT
admet-557	261	19	r.	r.	PROPN
admet-557	261	20	mullangi	mullangi	PROPN
admet-557	261	21	.	.	PUNCT
admet-557	262	1	validation	validation	NOUN
admet-557	262	2	of	of	ADP
admet-557	262	3	an	an	DET
admet-557	262	4	lc	lc	PROPN
admet-557	262	5	-	-	PUNCT
admet-557	262	6	ms	ms	PROPN
admet-557	262	7	/	/	SYM
admet-557	262	8	ms	ms	PROPN
admet-557	262	9	method	method	NOUN
admet-557	262	10	for	for	ADP
admet-557	262	11	simultaneous	simultaneous	ADJ
admet-557	262	12	quantitation	quantitation	NOUN
admet-557	262	13	of	of	ADP
admet-557	262	14	enzalutamide	enzalutamide	NOUN
admet-557	262	15	,	,	PUNCT
admet-557	262	16	n	n	CCONJ
admet-557	262	17	-	-	PUNCT
admet-557	262	18	desmethylenzalutamide	desmethylenzalutamide	ADJ
admet-557	262	19	,	,	PUNCT
admet-557	262	20	apalutamide	apalutamide	ADV
admet-557	262	21	,	,	PUNCT
admet-557	262	22	darolutamide	darolutamide	NOUN
admet-557	262	23	and	and	CCONJ
admet-557	262	24	orm-15341	orm-15341	NOUN
admet-557	262	25	in	in	ADP
admet-557	262	26	mice	mice	NOUN
admet-557	262	27	plasma	plasma	NOUN
admet-557	262	28	and	and	CCONJ
admet-557	262	29	its	its	PRON
admet-557	262	30	application	application	NOUN
admet-557	262	31	to	to	ADP
admet-557	262	32	a	a	DET
admet-557	262	33	mice	mice	NOUN
admet-557	262	34	pharmacokinetic	pharmacokinetic	ADJ
admet-557	262	35	study	study	NOUN
admet-557	262	36	.	.	PUNCT
admet-557	263	1	journal	journal	NOUN
admet-557	263	2	of	of	ADP
admet-557	263	3	pharmaceutical	pharmaceutical	NOUN
admet-557	263	4	and	and	CCONJ
admet-557	263	5	biomedical	biomedical	ADJ
admet-557	263	6	analysis	analysis	NOUN
admet-557	263	7	156	156	NUM
admet-557	263	8	(	(	PUNCT
admet-557	263	9	218	218	NUM
admet-557	263	10	)	)	PUNCT
admet-557	263	11	170	170	NUM
admet-557	263	12	-	-	SYM
admet-557	263	13	178	178	NUM
admet-557	263	14	.	.	PUNCT
admet-557	264	1	admet	admet	PROPN
admet-557	264	2	&	&	CCONJ
admet-557	264	3	dmpk	dmpk	PROPN
admet-557	264	4	6(3	6(3	PROPN
admet-557	264	5	)	)	PUNCT
admet-557	264	6	(	(	PUNCT
admet-557	264	7	2018	2018	NUM
admet-557	264	8	)	)	PUNCT
admet-557	264	9	242	242	NUM
admet-557	264	10	-	-	SYM
admet-557	264	11	257	257	NUM
admet-557	264	12	lc	lc	PROPN
admet-557	264	13	-	-	PUNCT
admet-557	264	14	ms	ms	PROPN
admet-557	264	15	/	/	SYM
admet-557	264	16	ms	ms	NOUN
admet-557	264	17	determination	determination	NOUN
admet-557	264	18	of	of	ADP
admet-557	264	19	enzalutamide	enzalutamide	ADV
admet-557	264	20	/	/	SYM
admet-557	264	21	darolutamide	darolutamide	NOUN
admet-557	264	22	with	with	ADP
admet-557	264	23	metabolites	metabolite	NOUN
admet-557	264	24	on	on	ADP
admet-557	264	25	dbs	dbs	PROPN
admet-557	264	26	doi	doi	PROPN
admet-557	264	27	:	:	PUNCT
admet-557	264	28	10.5599	10.5599	NUM
admet-557	264	29	/	/	SYM
admet-557	264	30	admet.557	admet.557	PROPN
admet-557	264	31	257	257	NUM
admet-557	264	32	[	[	SYM
admet-557	264	33	20	20	NUM
admet-557	264	34	]	]	PUNCT
admet-557	264	35	m.	m.	NOUN
admet-557	264	36	herbrink	herbrink	NOUN
admet-557	264	37	,	,	PUNCT
admet-557	264	38	n.	n.	PROPN
admet-557	264	39	de	de	PROPN
admet-557	264	40	vries	vries	PROPN
admet-557	264	41	,	,	PUNCT
admet-557	264	42	h.	h.	PROPN
admet-557	264	43	rosing	rosing	PROPN
admet-557	264	44	,	,	PUNCT
admet-557	264	45	a.d.r	a.d.r	PROPN
admet-557	264	46	.	.	PROPN
admet-557	264	47	huitema	huitema	PROPN
admet-557	264	48	,	,	PUNCT
admet-557	264	49	b.	b.	PROPN
admet-557	264	50	nuijen	nuijen	PROPN
admet-557	264	51	,	,	PUNCT
admet-557	264	52	j.h.m	j.h.m	PROPN
admet-557	264	53	.	.	PUNCT
admet-557	264	54	schellens	schellens	PROPN
admet-557	264	55	,	,	PUNCT
admet-557	264	56	j.h	j.h	PROPN
admet-557	264	57	.	.	PROPN
admet-557	264	58	beijnen	beijnen	PROPN
admet-557	264	59	.	.	PUNCT
admet-557	265	1	development	development	NOUN
admet-557	265	2	and	and	CCONJ
admet-557	265	3	validation	validation	NOUN
admet-557	265	4	of	of	ADP
admet-557	265	5	a	a	DET
admet-557	265	6	liquid	liquid	ADJ
admet-557	265	7	chromatography	chromatography	NOUN
admet-557	265	8	-	-	PUNCT
admet-557	265	9	tandem	tandem	NOUN
admet-557	265	10	mass	mass	PROPN
admet-557	265	11	spectrometry	spectrometry	NOUN
admet-557	265	12	analytical	analytical	ADJ
admet-557	265	13	method	method	NOUN
admet-557	265	14	for	for	ADP
admet-557	265	15	the	the	DET
admet-557	265	16	therapeutic	therapeutic	ADJ
admet-557	265	17	drug	drug	NOUN
admet-557	265	18	monitoring	monitoring	NOUN
admet-557	265	19	of	of	ADP
admet-557	265	20	eight	eight	NUM
admet-557	265	21	novel	novel	ADJ
admet-557	265	22	anticancer	anticancer	NOUN
admet-557	265	23	drugs	drug	NOUN
admet-557	265	24	.	.	PUNCT
admet-557	266	1	biomedical	biomedical	ADJ
admet-557	266	2	chromatography	chromatography	NOUN
admet-557	266	3	32	32	NUM
admet-557	266	4	(	(	PUNCT
admet-557	266	5	2017	2017	NUM
admet-557	266	6	)	)	PUNCT
admet-557	266	7	e4147	e4147	NOUN
admet-557	266	8	.	.	PUNCT
admet-557	267	1	[	[	X
admet-557	267	2	21	21	NUM
admet-557	267	3	]	]	X
admet-557	267	4	s.	s.	PROPN
admet-557	267	5	dittakavi	dittakavi	PROPN
admet-557	267	6	,	,	PUNCT
admet-557	267	7	p.k.v.s.p	p.k.v.s.p	PROPN
admet-557	267	8	.	.	PUNCT
admet-557	268	1	nagasuri	nagasuri	PROPN
admet-557	268	2	,	,	PUNCT
admet-557	268	3	s.p	s.p	PROPN
admet-557	268	4	.	.	PROPN
admet-557	268	5	sulochana	sulochana	PROPN
admet-557	268	6	,	,	PUNCT
admet-557	268	7	s.m	s.m	PROPN
admet-557	268	8	.	.	PROPN
admet-557	268	9	saim	saim	PROPN
admet-557	268	10	,	,	PUNCT
admet-557	268	11	s.r	s.r	PROPN
admet-557	268	12	.	.	PROPN
admet-557	268	13	mallurwar	mallurwar	PROPN
admet-557	268	14	,	,	PUNCT
admet-557	268	15	m.	m.	NOUN
admet-557	268	16	zainuddin	zainuddin	PROPN
admet-557	268	17	,	,	PUNCT
admet-557	268	18	p.	p.	PROPN
admet-557	268	19	dewang	dewang	PROPN
admet-557	268	20	,	,	PUNCT
admet-557	268	21	s.	s.	PROPN
admet-557	268	22	rajagopal	rajagopal	PROPN
admet-557	268	23	,	,	PUNCT
admet-557	268	24	r.	r.	PROPN
admet-557	268	25	mullangi	mullangi	PROPN
admet-557	268	26	.	.	PUNCT
admet-557	269	1	lc	lc	PROPN
admet-557	269	2	-	-	PUNCT
admet-557	269	3	ms	ms	PROPN
admet-557	269	4	/	/	SYM
admet-557	269	5	ms	ms	PROPN
admet-557	269	6	-	-	PUNCT
admet-557	269	7	esi	esi	PROPN
admet-557	269	8	method	method	NOUN
admet-557	269	9	for	for	ADP
admet-557	269	10	simultaneous	simultaneous	ADJ
admet-557	269	11	quantification	quantification	NOUN
admet-557	269	12	of	of	ADP
admet-557	269	13	darolutamide	darolutamide	NOUN
admet-557	269	14	and	and	CCONJ
admet-557	269	15	its	its	PRON
admet-557	269	16	active	active	ADJ
admet-557	269	17	metabolite	metabolite	NOUN
admet-557	269	18	,	,	PUNCT
admet-557	269	19	orm-15341	orm-15341	NOUN
admet-557	269	20	in	in	ADP
admet-557	269	21	mice	mice	NOUN
admet-557	269	22	plasma	plasma	NOUN
admet-557	269	23	and	and	CCONJ
admet-557	269	24	its	its	PRON
admet-557	269	25	application	application	NOUN
admet-557	269	26	to	to	ADP
admet-557	269	27	a	a	DET
admet-557	269	28	pharmacokinetic	pharmacokinetic	ADJ
admet-557	269	29	study	study	NOUN
admet-557	269	30	.	.	PUNCT
admet-557	270	1	journal	journal	NOUN
admet-557	270	2	of	of	ADP
admet-557	270	3	pharmaceutical	pharmaceutical	NOUN
admet-557	270	4	and	and	CCONJ
admet-557	270	5	biomedical	biomedical	ADJ
admet-557	270	6	analysis	analysis	NOUN
admet-557	270	7	145	145	NUM
admet-557	270	8	(	(	PUNCT
admet-557	270	9	2017	2017	NUM
admet-557	270	10	)	)	PUNCT
admet-557	270	11	454	454	NUM
admet-557	270	12	-	-	SYM
admet-557	270	13	461	461	NUM
admet-557	270	14	.	.	PUNCT
admet-557	271	1	[	[	X
admet-557	271	2	22	22	NUM
admet-557	271	3	]	]	X
admet-557	271	4	n.	n.	PROPN
admet-557	271	5	balaji	balaji	PROPN
admet-557	271	6	,	,	PUNCT
admet-557	271	7	s.p	s.p	PROPN
admet-557	271	8	.	.	PROPN
admet-557	271	9	sulochana	sulochana	PROPN
admet-557	271	10	,	,	PUNCT
admet-557	271	11	n.k	n.k	PROPN
admet-557	271	12	.	.	PROPN
admet-557	271	13	saini	saini	PROPN
admet-557	271	14	,	,	PUNCT
admet-557	271	15	a.s	a.s	PROPN
admet-557	271	16	.	.	PROPN
admet-557	271	17	kumar	kumar	PROPN
admet-557	271	18	,	,	PUNCT
admet-557	271	19	r.	r.	PROPN
admet-557	271	20	mullangi	mullangi	PROPN
admet-557	271	21	.	.	PUNCT
admet-557	272	1	validation	validation	NOUN
admet-557	272	2	of	of	ADP
admet-557	272	3	a	a	DET
admet-557	272	4	chiral	chiral	ADJ
admet-557	272	5	lc	lc	NOUN
admet-557	272	6	-	-	PUNCT
admet-557	272	7	ms	ms	PROPN
admet-557	272	8	/	/	SYM
admet-557	272	9	ms	ms	PROPN
admet-557	272	10	-	-	PUNCT
admet-557	272	11	esi	esi	PROPN
admet-557	272	12	method	method	NOUN
admet-557	272	13	for	for	ADP
admet-557	272	14	the	the	DET
admet-557	272	15	simultaneous	simultaneous	ADJ
admet-557	272	16	quantification	quantification	NOUN
admet-557	272	17	of	of	ADP
admet-557	272	18	darolutamide	darolutamide	ADJ
admet-557	272	19	diastereomers	diastereomer	NOUN
admet-557	272	20	in	in	ADP
admet-557	272	21	mice	mice	NOUN
admet-557	272	22	plasma	plasma	NOUN
admet-557	272	23	and	and	CCONJ
admet-557	272	24	its	its	PRON
admet-557	272	25	application	application	NOUN
admet-557	272	26	to	to	ADP
admet-557	272	27	a	a	DET
admet-557	272	28	stereoselective	stereoselective	ADJ
admet-557	272	29	pharmacokinetic	pharmacokinetic	ADJ
admet-557	272	30	study	study	NOUN
admet-557	272	31	in	in	ADP
admet-557	272	32	mice	mouse	NOUN
admet-557	272	33	.	.	PUNCT
admet-557	273	1	biomedical	biomedical	ADJ
admet-557	273	2	chromatography	chromatography	NOUN
admet-557	273	3	32	32	NUM
admet-557	273	4	(	(	PUNCT
admet-557	273	5	2018	2018	NUM
admet-557	273	6	)	)	PUNCT
admet-557	273	7	e4173	e4173	NOUN
admet-557	273	8	.	.	PUNCT
admet-557	274	1	[	[	X
admet-557	274	2	23	23	NUM
admet-557	274	3	]	]	X
admet-557	274	4	n.	n.	PROPN
admet-557	274	5	balaji	balaji	PROPN
admet-557	274	6	,	,	PUNCT
admet-557	274	7	s.p	s.p	PROPN
admet-557	274	8	.	.	PROPN
admet-557	274	9	sulochana	sulochana	PROPN
admet-557	274	10	,	,	PUNCT
admet-557	274	11	n.k	n.k	PROPN
admet-557	274	12	.	.	PROPN
admet-557	274	13	saini	saini	PROPN
admet-557	274	14	,	,	PUNCT
admet-557	274	15	a.s	a.s	PROPN
admet-557	274	16	.	.	PROPN
admet-557	274	17	kumar	kumar	PROPN
admet-557	274	18	,	,	PUNCT
admet-557	274	19	r.	r.	PROPN
admet-557	274	20	mullangi	mullangi	PROPN
admet-557	274	21	.	.	PUNCT
admet-557	275	1	validation	validation	NOUN
admet-557	275	2	of	of	ADP
admet-557	275	3	a	a	DET
admet-557	275	4	chiral	chiral	ADJ
admet-557	275	5	lc	lc	NOUN
admet-557	275	6	-	-	PUNCT
admet-557	275	7	ms	ms	PROPN
admet-557	275	8	/	/	SYM
admet-557	275	9	ms	ms	PROPN
admet-557	275	10	-	-	PUNCT
admet-557	275	11	esi	esi	PROPN
admet-557	275	12	method	method	NOUN
admet-557	275	13	for	for	ADP
admet-557	275	14	the	the	DET
admet-557	275	15	simultaneous	simultaneous	ADJ
admet-557	275	16	quantification	quantification	NOUN
admet-557	275	17	of	of	ADP
admet-557	275	18	darolutamide	darolutamide	ADJ
admet-557	275	19	diastereomers	diastereomer	NOUN
admet-557	275	20	and	and	CCONJ
admet-557	275	21	orm-15341	orm-15341	NOUN
admet-557	275	22	(	(	PUNCT
admet-557	275	23	active	active	ADJ
admet-557	275	24	metabolite	metabolite	NOUN
admet-557	275	25	)	)	PUNCT
admet-557	275	26	in	in	ADP
admet-557	275	27	mice	mice	NOUN
admet-557	275	28	plasma	plasma	NOUN
admet-557	275	29	:	:	PUNCT
admet-557	275	30	application	application	NOUN
admet-557	275	31	to	to	ADP
admet-557	275	32	a	a	DET
admet-557	275	33	pharmacokinetic	pharmacokinetic	ADJ
admet-557	275	34	study	study	NOUN
admet-557	275	35	in	in	ADP
admet-557	275	36	mice	mouse	NOUN
admet-557	275	37	.	.	PUNCT
admet-557	276	1	drug	drug	NOUN
admet-557	276	2	research	research	NOUN
admet-557	276	3	(	(	PUNCT
admet-557	276	4	2018	2018	NUM
admet-557	276	5	)	)	PUNCT
admet-557	276	6	in	in	ADP
admet-557	276	7	press	press	NOUN
admet-557	276	8	.	.	PUNCT
admet-557	277	1	[	[	X
admet-557	277	2	24	24	NUM
admet-557	277	3	]	]	X
admet-557	277	4	y.	y.	PROPN
admet-557	277	5	xu	xu	PROPN
admet-557	277	6	,	,	PUNCT
admet-557	277	7	e.j	e.j	PROPN
admet-557	277	8	.	.	PROPN
admet-557	277	9	woolf	woolf	PROPN
admet-557	277	10	,	,	PUNCT
admet-557	277	11	n.g	n.g	PROPN
admet-557	277	12	.	.	PROPN
admet-557	277	13	agrawal	agrawal	PROPN
admet-557	277	14	,	,	PUNCT
admet-557	277	15	p.	p.	NOUN
admet-557	277	16	kothare	kothare	PROPN
admet-557	277	17	,	,	PUNCT
admet-557	277	18	v.	v.	PROPN
admet-557	277	19	pucci	pucci	PROPN
admet-557	277	20	,	,	PUNCT
admet-557	277	21	k.p	k.p	PROPN
admet-557	277	22	.	.	PROPN
admet-557	277	23	bateman	bateman	PROPN
admet-557	277	24	.	.	PROPN
admet-557	278	1	merck	merck	PROPN
admet-557	278	2	's	's	PART
admet-557	278	3	perspective	perspective	NOUN
admet-557	278	4	on	on	ADP
admet-557	278	5	the	the	DET
admet-557	278	6	implementation	implementation	NOUN
admet-557	278	7	of	of	ADP
admet-557	278	8	dried	dry	VERB
admet-557	278	9	blood	blood	NOUN
admet-557	278	10	spot	spot	NOUN
admet-557	278	11	technology	technology	NOUN
admet-557	278	12	in	in	ADP
admet-557	278	13	clinical	clinical	ADJ
admet-557	278	14	drug	drug	NOUN
admet-557	278	15	development	development	NOUN
admet-557	278	16	why	why	SCONJ
admet-557	278	17	,	,	PUNCT
admet-557	278	18	when	when	SCONJ
admet-557	278	19	and	and	CCONJ
admet-557	278	20	how	how	SCONJ
admet-557	278	21	.	.	PUNCT
admet-557	279	1	bioanalysis	bioanalysis	NOUN
admet-557	279	2	5	5	NUM
admet-557	279	3	(	(	PUNCT
admet-557	279	4	2013	2013	NUM
admet-557	279	5	)	)	PUNCT
admet-557	279	6	341	341	NUM
admet-557	279	7	-	-	SYM
admet-557	279	8	350	350	NUM
admet-557	279	9	.	.	PUNCT
admet-557	280	1	[	[	X
admet-557	280	2	25	25	NUM
admet-557	280	3	]	]	X
admet-557	280	4	r.k	r.k	PROPN
admet-557	280	5	.	.	PROPN
admet-557	280	6	rej	rej	PROPN
admet-557	280	7	,	,	PUNCT
admet-557	280	8	r.k	r.k	PROPN
admet-557	280	9	.	.	PROPN
admet-557	280	10	acharyya	acharyya	PROPN
admet-557	280	11	,	,	PUNCT
admet-557	280	12	s.	s.	PROPN
admet-557	280	13	nanda	nanda	PROPN
admet-557	280	14	.	.	PUNCT
admet-557	281	1	asymmetric	asymmetric	ADJ
admet-557	281	2	synthesis	synthesis	NOUN
admet-557	281	3	of	of	ADP
admet-557	281	4	dihydroartemisinic	dihydroartemisinic	ADJ
admet-557	281	5	acid	acid	NOUN
admet-557	281	6	through	through	ADP
admet-557	281	7	intramolecular	intramolecular	ADJ
admet-557	281	8	stetter	stetter	NOUN
admet-557	281	9	reaction	reaction	NOUN
admet-557	281	10	.	.	PUNCT
admet-557	282	1	tetrahedron	tetrahedron	NOUN
admet-557	282	2	72	72	NUM
admet-557	282	3	(	(	PUNCT
admet-557	282	4	2016	2016	NUM
admet-557	282	5	)	)	PUNCT
admet-557	282	6	4931	4931	NUM
admet-557	282	7	-	-	SYM
admet-557	282	8	4937	4937	NUM
admet-557	282	9	.	.	PUNCT
admet-557	283	1	[	[	X
admet-557	283	2	26	26	NUM
admet-557	283	3	]	]	PUNCT
admet-557	283	4	x.	x.	NOUN
admet-557	283	5	pang	pang	PROPN
admet-557	283	6	,	,	PUNCT
admet-557	283	7	y.	y.	PROPN
admet-557	283	8	wang	wang	PROPN
admet-557	283	9	,	,	PUNCT
admet-557	283	10	y.	y.	PROPN
admet-557	283	11	chen	chen	PROPN
admet-557	283	12	.	.	PUNCT
admet-557	284	1	design	design	NOUN
admet-557	284	2	,	,	PUNCT
admet-557	284	3	synthesis	synthesis	NOUN
admet-557	284	4	,	,	PUNCT
admet-557	284	5	and	and	CCONJ
admet-557	284	6	biological	biological	ADJ
admet-557	284	7	evaluation	evaluation	NOUN
admet-557	284	8	of	of	ADP
admet-557	284	9	deuterated	deuterate	VERB
admet-557	284	10	apalutamide	apalutamide	ADV
admet-557	284	11	with	with	ADP
admet-557	284	12	improved	improved	ADJ
admet-557	284	13	pharmacokinetic	pharmacokinetic	ADJ
admet-557	284	14	profiles	profile	NOUN
admet-557	284	15	.	.	PUNCT
admet-557	285	1	bioorganic	bioorganic	PROPN
admet-557	285	2	&	&	CCONJ
admet-557	285	3	medicinal	medicinal	ADJ
admet-557	285	4	chemistry	chemistry	NOUN
admet-557	285	5	letters	letter	NOUN
admet-557	285	6	27	27	NUM
admet-557	285	7	(	(	PUNCT
admet-557	285	8	2017	2017	NUM
admet-557	285	9	)	)	PUNCT
admet-557	285	10	28032806	28032806	NUM
admet-557	285	11	.	.	PUNCT
admet-557	286	1	[	[	X
admet-557	286	2	27	27	NUM
admet-557	286	3	]	]	X
admet-557	286	4	us	us	PROPN
admet-557	286	5	dhhs	dhhs	PROPN
admet-557	286	6	,	,	PUNCT
admet-557	286	7	fda	fda	PROPN
admet-557	286	8	,	,	PUNCT
admet-557	286	9	cder	cder	NOUN
admet-557	286	10	,	,	PUNCT
admet-557	286	11	cvm	cvm	PROPN
admet-557	286	12	,	,	PUNCT
admet-557	286	13	guidance	guidance	NOUN
admet-557	286	14	for	for	ADP
admet-557	286	15	industry	industry	NOUN
admet-557	286	16	:	:	PUNCT
admet-557	286	17	bioanalytical	bioanalytical	ADJ
admet-557	286	18	method	method	NOUN
admet-557	286	19	validation	validation	NOUN
admet-557	286	20	,	,	PUNCT
admet-557	286	21	u.s	u.s	PROPN
admet-557	286	22	.	.	PROPN
admet-557	286	23	department	department	PROPN
admet-557	286	24	of	of	ADP
admet-557	286	25	health	health	PROPN
admet-557	286	26	and	and	CCONJ
admet-557	286	27	human	human	ADJ
admet-557	286	28	services	service	NOUN
admet-557	286	29	,	,	PUNCT
admet-557	286	30	food	food	NOUN
admet-557	286	31	and	and	CCONJ
admet-557	286	32	drug	drug	NOUN
admet-557	286	33	administration	administration	NOUN
admet-557	286	34	,	,	PUNCT
admet-557	286	35	center	center	NOUN
admet-557	286	36	for	for	ADP
admet-557	286	37	drug	drug	NOUN
admet-557	286	38	evaluation	evaluation	NOUN
admet-557	286	39	and	and	CCONJ
admet-557	286	40	research	research	NOUN
admet-557	286	41	(	(	PUNCT
admet-557	286	42	cder	cder	NOUN
admet-557	286	43	)	)	PUNCT
admet-557	286	44	,	,	PUNCT
admet-557	286	45	center	center	NOUN
admet-557	286	46	for	for	ADP
admet-557	286	47	veterinary	veterinary	ADJ
admet-557	286	48	medicine	medicine	NOUN
admet-557	286	49	(	(	PUNCT
admet-557	286	50	cv	cv	PROPN
admet-557	286	51	)	)	PUNCT
admet-557	286	52	,	,	PUNCT
admet-557	286	53	(	(	PUNCT
admet-557	286	54	2018	2018	NUM
admet-557	286	55	)	)	PUNCT
admet-557	286	56	,	,	PUNCT
admet-557	286	57	rockville	rockville	PROPN
admet-557	286	58	,	,	PUNCT
admet-557	286	59	md	md	PROPN
admet-557	286	60	,	,	PUNCT
admet-557	286	61	usa	usa	PROPN
admet-557	286	62	.	.	PUNCT
admet-557	287	1	[	[	X
admet-557	287	2	28	28	NUM
admet-557	287	3	]	]	X
admet-557	287	4	p.	p.	NOUN
admet-557	287	5	a.	a.	PROPN
admet-557	287	6	demirev	demirev	PROPN
admet-557	287	7	.	.	PUNCT
admet-557	288	1	dried	dry	VERB
admet-557	288	2	blood	blood	NOUN
admet-557	288	3	spots	spot	NOUN
admet-557	288	4	:	:	PUNCT
admet-557	288	5	analysis	analysis	NOUN
admet-557	288	6	and	and	CCONJ
admet-557	288	7	applications	application	NOUN
admet-557	288	8	.	.	PUNCT
admet-557	289	1	analytical	analytical	ADJ
admet-557	289	2	chemistry	chemistry	NOUN
admet-557	289	3	85	85	NUM
admet-557	289	4	(	(	PUNCT
admet-557	289	5	2013	2013	NUM
admet-557	289	6	)	)	PUNCT
admet-557	289	7	779	779	NUM
admet-557	289	8	-	-	SYM
admet-557	289	9	789	789	NUM
admet-557	289	10	.	.	PUNCT
admet-557	290	1	[	[	X
admet-557	290	2	29	29	NUM
admet-557	290	3	]	]	X
admet-557	290	4	j.d	j.d	PROPN
admet-557	290	5	.	.	PROPN
admet-557	290	6	freeman	freeman	PROPN
admet-557	290	7	,	,	PUNCT
admet-557	290	8	l.m	l.m	PROPN
admet-557	290	9	.	.	PROPN
admet-557	290	10	rosman	rosman	PROPN
admet-557	290	11	,	,	PUNCT
admet-557	290	12	j.d	j.d	PROPN
admet-557	290	13	.	.	PROPN
admet-557	290	14	ratcliff	ratcliff	PROPN
admet-557	290	15	,	,	PUNCT
admet-557	290	16	p.t	p.t	PROPN
admet-557	290	17	.	.	PROPN
admet-557	290	18	strickland	strickland	PROPN
admet-557	290	19	,	,	PUNCT
admet-557	290	20	d.r	d.r	PROPN
admet-557	290	21	.	.	PROPN
admet-557	290	22	graham	graham	PROPN
admet-557	290	23	,	,	PUNCT
admet-557	290	24	e.k	e.k	PROPN
admet-557	290	25	.	.	PROPN
admet-557	290	26	silbergeld	silbergeld	PROPN
admet-557	290	27	.	.	PUNCT
admet-557	291	1	state	state	NOUN
admet-557	291	2	of	of	ADP
admet-557	291	3	the	the	DET
admet-557	291	4	science	science	NOUN
admet-557	291	5	in	in	ADP
admet-557	291	6	dried	dry	VERB
admet-557	291	7	blood	blood	NOUN
admet-557	291	8	spots	spot	NOUN
admet-557	291	9	.	.	PUNCT
admet-557	292	1	clinical	clinical	ADJ
admet-557	292	2	chemistry	chemistry	NOUN
admet-557	292	3	64	64	NUM
admet-557	292	4	(	(	PUNCT
admet-557	292	5	2018	2018	NUM
admet-557	292	6	)	)	PUNCT
admet-557	292	7	656	656	NUM
admet-557	292	8	-	-	SYM
admet-557	292	9	679	679	NUM
admet-557	292	10	.	.	PUNCT
admet-557	293	1	©	©	PROPN
admet-557	293	2	2018	2018	NUM
admet-557	293	3	by	by	ADP
admet-557	293	4	the	the	DET
admet-557	293	5	authors	author	NOUN
admet-557	293	6	;	;	PUNCT
admet-557	294	1	licensee	licensee	PROPN
admet-557	294	2	iapc	iapc	PROPN
admet-557	294	3	,	,	PUNCT
admet-557	294	4	zagreb	zagreb	PROPN
admet-557	294	5	,	,	PUNCT
admet-557	294	6	croatia	croatia	PROPN
admet-557	294	7	.	.	PUNCT
admet-557	295	1	this	this	DET
admet-557	295	2	article	article	NOUN
admet-557	295	3	is	be	AUX
admet-557	295	4	an	an	DET
admet-557	295	5	open	open	ADJ
admet-557	295	6	-	-	PUNCT
admet-557	295	7	access	access	NOUN
admet-557	295	8	article	article	NOUN
admet-557	295	9	distributed	distribute	VERB
admet-557	295	10	under	under	ADP
admet-557	295	11	the	the	DET
admet-557	295	12	terms	term	NOUN
admet-557	295	13	and	and	CCONJ
admet-557	295	14	conditions	condition	NOUN
admet-557	295	15	of	of	ADP
admet-557	295	16	the	the	DET
admet-557	295	17	creative	creative	ADJ
admet-557	295	18	commons	common	NOUN
admet-557	295	19	attribution	attribution	NOUN
admet-557	295	20	license	license	NOUN
admet-557	295	21	(	(	PUNCT
admet-557	295	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-557	295	23	)	)	PUNCT
admet-557	295	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN