id	sid	tid	token	lemma	pos
admet-579	1	1	pkquest	pkquest	NOUN
admet-579	1	2	:	:	PUNCT
admet-579	1	3	pbpk	pbpk	NOUN
admet-579	1	4	modeling	modeling	NOUN
admet-579	1	5	of	of	ADP
admet-579	1	6	highly	highly	ADV
admet-579	1	7	lipid	lipid	ADJ
admet-579	1	8	soluble	soluble	ADJ
admet-579	1	9	and	and	CCONJ
admet-579	1	10	extracellular	extracellular	ADJ
admet-579	1	11	solutes	solute	NOUN
admet-579	1	12	doi	doi	NOUN
admet-579	1	13	:	:	PUNCT
admet-579	1	14	10.5599	10.5599	NUM
admet-579	1	15	/	/	SYM
admet-579	1	16	admet.579	admet.579	NOUN
admet-579	1	17	60	60	NUM
admet-579	1	18	admet	admet	PROPN
admet-579	1	19	&	&	CCONJ
admet-579	1	20	dmpk	dmpk	PROPN
admet-579	1	21	7(1	7(1	PROPN
admet-579	1	22	)	)	PUNCT
admet-579	1	23	(	(	PUNCT
admet-579	1	24	2019	2019	NUM
admet-579	1	25	)	)	PUNCT
admet-579	1	26	60	60	NUM
admet-579	1	27	-	-	SYM
admet-579	1	28	75	75	NUM
admet-579	1	29	;	;	PUNCT
admet-579	1	30	doi	doi	NOUN
admet-579	1	31	:	:	PUNCT
admet-579	1	32	http://dx.doi.org/10.5599/admet.579	http://dx.doi.org/10.5599/admet.579	NOUN
admet-579	1	33	open	open	ADJ
admet-579	1	34	access	access	NOUN
admet-579	1	35	:	:	PUNCT
admet-579	1	36	issn	issn	NOUN
admet-579	1	37	:	:	PUNCT
admet-579	1	38	1848	1848	NUM
admet-579	1	39	-	-	SYM
admet-579	1	40	7718	7718	NUM
admet-579	1	41	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-579	1	42	original	original	ADJ
admet-579	1	43	scientific	scientific	ADJ
admet-579	1	44	paper	paper	NOUN
admet-579	1	45	pkquest	pkquest	NOUN
admet-579	1	46	:	:	PUNCT
admet-579	1	47	pbpk	pbpk	NOUN
admet-579	1	48	modeling	modeling	NOUN
admet-579	1	49	of	of	ADP
admet-579	1	50	highly	highly	ADV
admet-579	1	51	lipid	lipid	ADJ
admet-579	1	52	soluble	soluble	ADJ
admet-579	1	53	and	and	CCONJ
admet-579	1	54	extracellular	extracellular	ADJ
admet-579	1	55	solutes	solute	NOUN
admet-579	1	56	david	david	PROPN
admet-579	1	57	g.	g.	PROPN
admet-579	1	58	levitt	levitt	PROPN
admet-579	1	59	department	department	PROPN
admet-579	1	60	of	of	ADP
admet-579	1	61	integrative	integrative	ADJ
admet-579	1	62	biology	biology	NOUN
admet-579	1	63	and	and	CCONJ
admet-579	1	64	physiology	physiology	NOUN
admet-579	1	65	,	,	PUNCT
admet-579	1	66	university	university	NOUN
admet-579	1	67	of	of	ADP
admet-579	1	68	minnesota	minnesota	PROPN
admet-579	1	69	,	,	PUNCT
admet-579	1	70	6	6	NUM
admet-579	1	71	-	-	SYM
admet-579	1	72	125	125	NUM
admet-579	1	73	jackson	jackson	PROPN
admet-579	1	74	hall	hall	PROPN
admet-579	1	75	,	,	PUNCT
admet-579	1	76	321	321	NUM
admet-579	1	77	church	church	PROPN
admet-579	1	78	st	st	PROPN
admet-579	1	79	.	.	PROPN
admet-579	1	80	s.	s.	PROPN
admet-579	1	81	e.	e.	PROPN
admet-579	1	82	,	,	PUNCT
admet-579	1	83	minneapolis	minneapolis	PROPN
admet-579	1	84	,	,	PUNCT
admet-579	1	85	mn	mn	PROPN
admet-579	1	86	55455	55455	NUM
admet-579	1	87	,	,	PUNCT
admet-579	1	88	usa	usa	PROPN
admet-579	1	89	e	e	PROPN
admet-579	1	90	-	-	NOUN
admet-579	1	91	mail	mail	NOUN
admet-579	1	92	:	:	PUNCT
admet-579	1	93	levit001@umn.edu	levit001@umn.edu	PROPN
admet-579	1	94	received	receive	VERB
admet-579	1	95	:	:	PUNCT
admet-579	1	96	august	august	PROPN
admet-579	1	97	12	12	NUM
admet-579	1	98	,	,	PUNCT
admet-579	1	99	2018	2018	NUM
admet-579	1	100	;	;	PUNCT
admet-579	1	101	revised	revise	VERB
admet-579	1	102	:	:	PUNCT
admet-579	1	103	november	november	PROPN
admet-579	1	104	16	16	NUM
admet-579	1	105	,	,	PUNCT
admet-579	1	106	2018	2018	NUM
admet-579	1	107	;	;	PUNCT
admet-579	1	108	published	publish	VERB
admet-579	1	109	:	:	PUNCT
admet-579	1	110	november	november	PROPN
admet-579	1	111	27	27	NUM
admet-579	1	112	,	,	PUNCT
admet-579	1	113	2018	2018	NUM
admet-579	1	114	abstract	abstract	ADJ
admet-579	1	115	one	one	NUM
admet-579	1	116	of	of	ADP
admet-579	1	117	the	the	DET
admet-579	1	118	primary	primary	ADJ
admet-579	1	119	objectives	objective	NOUN
admet-579	1	120	of	of	ADP
admet-579	1	121	physiologically	physiologically	ADV
admet-579	1	122	based	base	VERB
admet-579	1	123	pharmacokinetics	pharmacokinetic	NOUN
admet-579	1	124	(	(	PUNCT
admet-579	1	125	pbpk	pbpk	NOUN
admet-579	1	126	)	)	PUNCT
admet-579	1	127	is	be	AUX
admet-579	1	128	the	the	DET
admet-579	1	129	prediction	prediction	NOUN
admet-579	1	130	of	of	ADP
admet-579	1	131	a	a	DET
admet-579	1	132	drug	drug	NOUN
admet-579	1	133	’s	’s	PART
admet-579	1	134	pharmacokinetics	pharmacokinetic	NOUN
admet-579	1	135	just	just	ADV
admet-579	1	136	from	from	ADP
admet-579	1	137	knowledge	knowledge	NOUN
admet-579	1	138	of	of	ADP
admet-579	1	139	its	its	PRON
admet-579	1	140	physicochemical	physicochemical	ADJ
admet-579	1	141	structure	structure	NOUN
admet-579	1	142	.	.	PUNCT
admet-579	2	1	unfortunately	unfortunately	ADV
admet-579	2	2	,	,	PUNCT
admet-579	2	3	at	at	ADP
admet-579	2	4	present	present	ADJ
admet-579	2	5	,	,	PUNCT
admet-579	2	6	the	the	DET
admet-579	2	7	accuracy	accuracy	NOUN
admet-579	2	8	of	of	ADP
admet-579	2	9	this	this	DET
admet-579	2	10	prediction	prediction	NOUN
admet-579	2	11	is	be	AUX
admet-579	2	12	limited	limit	VERB
admet-579	2	13	for	for	ADP
admet-579	2	14	most	most	ADJ
admet-579	2	15	drugs	drug	NOUN
admet-579	2	16	because	because	SCONJ
admet-579	2	17	of	of	ADP
admet-579	2	18	uncertainty	uncertainty	NOUN
admet-579	2	19	about	about	ADP
admet-579	2	20	the	the	DET
admet-579	2	21	drug	drug	NOUN
admet-579	2	22	’s	’s	PART
admet-579	2	23	organ	organ	NOUN
admet-579	2	24	/	/	SYM
admet-579	2	25	blood	blood	NOUN
admet-579	2	26	partition	partition	NOUN
admet-579	2	27	coefficient	coefficient	NOUN
admet-579	2	28	(	(	PUNCT
admet-579	2	29	k	k	NOUN
admet-579	2	30	)	)	PUNCT
admet-579	2	31	.	.	PUNCT
admet-579	3	1	however	however	ADV
admet-579	3	2	,	,	PUNCT
admet-579	3	3	there	there	PRON
admet-579	3	4	are	be	VERB
admet-579	3	5	two	two	NUM
admet-579	3	6	classes	class	NOUN
admet-579	3	7	of	of	ADP
admet-579	3	8	solutes	solute	NOUN
admet-579	3	9	which	which	PRON
admet-579	3	10	are	be	AUX
admet-579	3	11	exceptions	exception	NOUN
admet-579	3	12	to	to	ADP
admet-579	3	13	this	this	PRON
admet-579	3	14	:	:	PUNCT
admet-579	3	15	1	1	X
admet-579	3	16	)	)	PUNCT
admet-579	3	17	the	the	DET
admet-579	3	18	highly	highly	ADV
admet-579	3	19	lipid	lipid	ADJ
admet-579	3	20	soluble	soluble	ADJ
admet-579	3	21	(	(	PUNCT
admet-579	3	22	hls	hls	NOUN
admet-579	3	23	)	)	PUNCT
admet-579	3	24	solutes	solute	NOUN
admet-579	3	25	,	,	PUNCT
admet-579	3	26	and	and	CCONJ
admet-579	3	27	2	2	X
admet-579	3	28	)	)	PUNCT
admet-579	3	29	the	the	DET
admet-579	3	30	extracellular	extracellular	ADJ
admet-579	3	31	(	(	PUNCT
admet-579	3	32	ecs	ecs	NOUN
admet-579	3	33	)	)	PUNCT
admet-579	3	34	solutes	solute	NOUN
admet-579	3	35	.	.	PUNCT
admet-579	4	1	since	since	SCONJ
admet-579	4	2	the	the	DET
admet-579	4	3	hls	hls	NOUN
admet-579	4	4	drugs	drug	NOUN
admet-579	4	5	(	(	PUNCT
admet-579	4	6	eg	eg	NOUN
admet-579	4	7	,	,	PUNCT
admet-579	4	8	volatile	volatile	ADJ
admet-579	4	9	anesthetics	anesthetic	NOUN
admet-579	4	10	,	,	PUNCT
admet-579	4	11	propofol	propofol	NOUN
admet-579	4	12	,	,	PUNCT
admet-579	4	13	cannabinol	cannabinol	NOUN
admet-579	4	14	)	)	PUNCT
admet-579	4	15	have	have	VERB
admet-579	4	16	lipid	lipid	NOUN
admet-579	4	17	/	/	SYM
admet-579	4	18	water	water	NOUN
admet-579	4	19	partition	partition	NOUN
admet-579	4	20	coefficients	coefficient	NOUN
admet-579	4	21	(	(	PUNCT
admet-579	4	22	pl	pl	NOUN
admet-579	4	23	/	/	SYM
admet-579	4	24	w	w	NOUN
admet-579	4	25	)	)	PUNCT
admet-579	4	26	of	of	ADP
admet-579	4	27	100	100	NUM
admet-579	4	28	or	or	CCONJ
admet-579	4	29	greater	great	ADJ
admet-579	4	30	,	,	PUNCT
admet-579	4	31	their	their	PRON
admet-579	4	32	k	k	NOUN
admet-579	4	33	is	be	AUX
admet-579	4	34	dominated	dominate	VERB
admet-579	4	35	by	by	ADP
admet-579	4	36	the	the	DET
admet-579	4	37	tissue	tissue	NOUN
admet-579	4	38	fat	fat	ADJ
admet-579	4	39	fraction	fraction	NOUN
admet-579	4	40	and	and	CCONJ
admet-579	4	41	one	one	NOUN
admet-579	4	42	can	can	AUX
admet-579	4	43	accurately	accurately	ADV
admet-579	4	44	predict	predict	VERB
admet-579	4	45	k	k	PROPN
admet-579	4	46	just	just	ADV
admet-579	4	47	from	from	ADP
admet-579	4	48	in	in	ADP
admet-579	4	49	vitro	vitro	X
admet-579	4	50	measurements	measurement	NOUN
admet-579	4	51	of	of	ADP
admet-579	4	52	pl	pl	PROPN
admet-579	4	53	/	/	SYM
admet-579	4	54	w	w	NOUN
admet-579	4	55	along	along	ADP
admet-579	4	56	with	with	ADP
admet-579	4	57	prior	prior	ADJ
admet-579	4	58	anatomic	anatomic	ADJ
admet-579	4	59	measurements	measurement	NOUN
admet-579	4	60	of	of	ADP
admet-579	4	61	the	the	DET
admet-579	4	62	fat	fat	ADJ
admet-579	4	63	fraction	fraction	NOUN
admet-579	4	64	of	of	ADP
admet-579	4	65	the	the	DET
admet-579	4	66	organs	organ	NOUN
admet-579	4	67	in	in	ADP
admet-579	4	68	the	the	DET
admet-579	4	69	pbpk	pbpk	ADJ
admet-579	4	70	model	model	NOUN
admet-579	4	71	.	.	PUNCT
admet-579	5	1	since	since	SCONJ
admet-579	5	2	the	the	DET
admet-579	5	3	ecs	ecs	PROPN
admet-579	5	4	drugs	drug	NOUN
admet-579	5	5	,	,	PUNCT
admet-579	5	6	such	such	ADJ
admet-579	5	7	as	as	ADP
admet-579	5	8	most	most	ADJ
admet-579	5	9	antibiotics	antibiotic	NOUN
admet-579	5	10	,	,	PUNCT
admet-579	5	11	can	can	AUX
admet-579	5	12	not	not	PART
admet-579	5	13	penetrate	penetrate	VERB
admet-579	5	14	cells	cell	NOUN
admet-579	5	15	,	,	PUNCT
admet-579	5	16	they	they	PRON
admet-579	5	17	are	be	AUX
admet-579	5	18	not	not	PART
admet-579	5	19	subject	subject	ADJ
admet-579	5	20	to	to	ADP
admet-579	5	21	the	the	DET
admet-579	5	22	intracellular	intracellular	ADJ
admet-579	5	23	binding	binding	NOUN
admet-579	5	24	that	that	PRON
admet-579	5	25	complicates	complicate	VERB
admet-579	5	26	the	the	DET
admet-579	5	27	prediction	prediction	NOUN
admet-579	5	28	of	of	ADP
admet-579	5	29	k	k	PROPN
admet-579	5	30	for	for	ADP
admet-579	5	31	the	the	DET
admet-579	5	32	weak	weak	ADJ
admet-579	5	33	bases	basis	NOUN
admet-579	5	34	and	and	CCONJ
admet-579	5	35	acids	acid	NOUN
admet-579	5	36	.	.	PUNCT
admet-579	6	1	the	the	DET
admet-579	6	2	ecs	ecs	PROPN
admet-579	6	3	k	k	PROPN
admet-579	6	4	is	be	AUX
admet-579	6	5	determined	determine	VERB
admet-579	6	6	primarily	primarily	ADV
admet-579	6	7	by	by	ADP
admet-579	6	8	plasma	plasma	NOUN
admet-579	6	9	and	and	CCONJ
admet-579	6	10	interstitial	interstitial	ADJ
admet-579	6	11	albumin	albumin	NOUN
admet-579	6	12	binding	bind	VERB
admet-579	6	13	and	and	CCONJ
admet-579	6	14	can	can	AUX
admet-579	6	15	be	be	AUX
admet-579	6	16	predicted	predict	VERB
admet-579	6	17	from	from	ADP
admet-579	6	18	in	in	ADP
admet-579	6	19	vitro	vitro	X
admet-579	6	20	measurements	measurement	NOUN
admet-579	6	21	of	of	ADP
admet-579	6	22	plasma	plasma	NOUN
admet-579	6	23	albumin	albumin	NOUN
admet-579	6	24	binding	bind	VERB
admet-579	6	25	along	along	ADP
admet-579	6	26	with	with	ADP
admet-579	6	27	prior	prior	ADJ
admet-579	6	28	measurements	measurement	NOUN
admet-579	6	29	of	of	ADP
admet-579	6	30	interstitial	interstitial	ADJ
admet-579	6	31	tissue	tissue	NOUN
admet-579	6	32	volume	volume	NOUN
admet-579	6	33	and	and	CCONJ
admet-579	6	34	albumin	albumin	ADJ
admet-579	6	35	concentrations	concentration	NOUN
admet-579	6	36	.	.	PUNCT
admet-579	7	1	this	this	DET
admet-579	7	2	review	review	NOUN
admet-579	7	3	provides	provide	VERB
admet-579	7	4	an	an	DET
admet-579	7	5	in	in	ADP
admet-579	7	6	depth	depth	NOUN
admet-579	7	7	discussion	discussion	NOUN
admet-579	7	8	of	of	ADP
admet-579	7	9	the	the	DET
admet-579	7	10	pbpk	pbpk	NOUN
admet-579	7	11	modeling	modeling	NOUN
admet-579	7	12	of	of	ADP
admet-579	7	13	these	these	DET
admet-579	7	14	two	two	NUM
admet-579	7	15	drug	drug	NOUN
admet-579	7	16	classes	class	NOUN
admet-579	7	17	along	along	ADP
admet-579	7	18	with	with	ADP
admet-579	7	19	many	many	ADJ
admet-579	7	20	specific	specific	ADJ
admet-579	7	21	clinical	clinical	ADJ
admet-579	7	22	examples	example	NOUN
admet-579	7	23	illustrating	illustrate	VERB
admet-579	7	24	the	the	DET
admet-579	7	25	good	good	ADJ
admet-579	7	26	pbpk	pbpk	ADJ
admet-579	7	27	predictions	prediction	NOUN
admet-579	7	28	possible	possible	ADJ
admet-579	7	29	with	with	ADP
admet-579	7	30	just	just	ADV
admet-579	7	31	zero	zero	NUM
admet-579	7	32	(	(	PUNCT
admet-579	7	33	volatile	volatile	ADJ
admet-579	7	34	anesthetics	anesthetic	NOUN
admet-579	7	35	)	)	PUNCT
admet-579	7	36	or	or	CCONJ
admet-579	7	37	1	1	NUM
admet-579	7	38	(	(	PUNCT
admet-579	7	39	the	the	DET
admet-579	7	40	clearance	clearance	NOUN
admet-579	7	41	)	)	PUNCT
admet-579	7	42	adjustable	adjustable	ADJ
admet-579	7	43	parameter	parameter	NOUN
admet-579	7	44	.	.	PUNCT
admet-579	8	1	the	the	DET
admet-579	8	2	pbpk	pbpk	PROPN
admet-579	8	3	analysis	analysis	NOUN
admet-579	8	4	uses	use	VERB
admet-579	8	5	pkquest	pkquest	NOUN
admet-579	8	6	,	,	PUNCT
admet-579	8	7	a	a	DET
admet-579	8	8	freely	freely	ADV
admet-579	8	9	distributed	distribute	VERB
admet-579	8	10	,	,	PUNCT
admet-579	8	11	general	general	ADJ
admet-579	8	12	purpose	purpose	NOUN
admet-579	8	13	pharmacokinetic	pharmacokinetic	ADJ
admet-579	8	14	program	program	NOUN
admet-579	8	15	.	.	PUNCT
admet-579	9	1	pkquest	pkquest	PROPN
admet-579	9	2	is	be	AUX
admet-579	9	3	designed	design	VERB
admet-579	9	4	so	so	SCONJ
admet-579	9	5	that	that	PRON
admet-579	9	6	application	application	NOUN
admet-579	9	7	to	to	ADP
admet-579	9	8	the	the	DET
admet-579	9	9	hls	hls	NOUN
admet-579	9	10	and	and	CCONJ
admet-579	9	11	ecs	ecs	PROPN
admet-579	9	12	solute	solute	PROPN
admet-579	9	13	classes	class	NOUN
admet-579	9	14	is	be	AUX
admet-579	9	15	especially	especially	ADV
admet-579	9	16	easy	easy	ADJ
admet-579	9	17	.	.	PUNCT
admet-579	10	1	the	the	DET
admet-579	10	2	user	user	NOUN
admet-579	10	3	only	only	ADV
admet-579	10	4	needs	need	VERB
admet-579	10	5	to	to	PART
admet-579	10	6	enter	enter	VERB
admet-579	10	7	the	the	DET
admet-579	10	8	specific	specific	ADJ
admet-579	10	9	parameters	parameter	NOUN
admet-579	10	10	that	that	PRON
admet-579	10	11	are	be	AUX
admet-579	10	12	required	require	VERB
admet-579	10	13	to	to	PART
admet-579	10	14	characterize	characterize	VERB
admet-579	10	15	the	the	DET
admet-579	10	16	drug	drug	NOUN
admet-579	10	17	(	(	PUNCT
admet-579	10	18	eg	eg	NOUN
admet-579	10	19	,	,	PUNCT
admet-579	10	20	pl	pl	PROPN
admet-579	10	21	/	/	SYM
admet-579	10	22	w	w	PROPN
admet-579	10	23	for	for	ADP
admet-579	10	24	hls	hls	NOUN
admet-579	10	25	or	or	CCONJ
admet-579	10	26	plasma	plasma	NOUN
admet-579	10	27	albumin	albumin	NOUN
admet-579	10	28	binding	bind	VERB
admet-579	10	29	for	for	ADP
admet-579	10	30	ecs	ec	NOUN
admet-579	10	31	)	)	PUNCT
admet-579	10	32	with	with	ADP
admet-579	10	33	all	all	DET
admet-579	10	34	the	the	DET
admet-579	10	35	other	other	ADJ
admet-579	10	36	pbpk	pbpk	ADJ
admet-579	10	37	parameters	parameter	NOUN
admet-579	10	38	(	(	PUNCT
admet-579	10	39	organ	organ	NOUN
admet-579	10	40	blood	blood	NOUN
admet-579	10	41	flow	flow	NOUN
admet-579	10	42	,	,	PUNCT
admet-579	10	43	fat	fat	ADJ
admet-579	10	44	fraction	fraction	NOUN
admet-579	10	45	,	,	PUNCT
admet-579	10	46	extracellular	extracellular	ADJ
admet-579	10	47	volumes	volume	NOUN
admet-579	10	48	,	,	PUNCT
admet-579	10	49	etc	etc	X
admet-579	10	50	.	.	X
admet-579	10	51	)	)	PUNCT
admet-579	10	52	are	be	AUX
admet-579	10	53	set	set	VERB
admet-579	10	54	by	by	ADP
admet-579	10	55	default	default	NOUN
admet-579	10	56	.	.	PUNCT
admet-579	11	1	keywords	keyword	VERB
admet-579	11	2	pharmacokinetics	pharmacokinetic	NOUN
admet-579	11	3	;	;	PUNCT
admet-579	11	4	anesthetics	anesthetic	NOUN
admet-579	11	5	;	;	PUNCT
admet-579	11	6	interstitial	interstitial	ADJ
admet-579	11	7	;	;	PUNCT
admet-579	11	8	extracellular	extracellular	ADJ
admet-579	11	9	;	;	PUNCT
admet-579	12	1	adipose	adipose	ADP
admet-579	12	2	introduction	introduction	NOUN
admet-579	12	3	the	the	DET
admet-579	12	4	standard	standard	ADJ
admet-579	12	5	well	well	ADV
admet-579	12	6	-	-	PUNCT
admet-579	12	7	stirred	stir	VERB
admet-579	12	8	,	,	PUNCT
admet-579	12	9	flow	flow	NOUN
admet-579	12	10	-	-	PUNCT
admet-579	12	11	limited	limit	VERB
admet-579	12	12	pbpk	pbpk	NOUN
admet-579	12	13	differential	differential	ADJ
admet-579	12	14	equation	equation	NOUN
admet-579	12	15	describing	describe	VERB
admet-579	12	16	the	the	DET
admet-579	12	17	solute	solute	NOUN
admet-579	12	18	balance	balance	NOUN
admet-579	12	19	of	of	ADP
admet-579	12	20	organ	organ	NOUN
admet-579	12	21	i	i	PRON
admet-579	12	22	is	be	AUX
admet-579	12	23	deceptively	deceptively	ADV
admet-579	12	24	simple	simple	ADJ
admet-579	12	25	[	[	X
admet-579	12	26	1	1	NUM
admet-579	12	27	]	]	PUNCT
admet-579	12	28	:	:	PUNCT
admet-579	12	29	i	i	PRON
admet-579	12	30	i	i	PRON
admet-579	13	1	i	i	PRON
admet-579	13	2	a	a	PRON
admet-579	13	3	i	i	NOUN
admet-579	13	4	d	d	PROPN
admet-579	13	5	(	(	PUNCT
admet-579	13	6	)	)	PUNCT
admet-579	14	1	[	[	X
admet-579	14	2	c	c	X
admet-579	14	3	(	(	PUNCT
admet-579	14	4	)	)	PUNCT
admet-579	14	5	(	(	PUNCT
admet-579	14	6	)	)	PUNCT
admet-579	14	7	]	]	PUNCT
admet-579	15	1	d	d	X
admet-579	15	2	c	c	PROPN
admet-579	15	3	t	t	PROPN
admet-579	15	4	v	v	NOUN
admet-579	15	5	f	f	PROPN
admet-579	15	6	t	t	PROPN
admet-579	15	7	c	c	PROPN
admet-579	15	8	t	t	PROPN
admet-579	15	9	t	t	PROPN
admet-579	15	10			PROPN
admet-579	15	11			PROPN
admet-579	15	12	(	(	PUNCT
admet-579	15	13	1	1	NUM
admet-579	15	14	)	)	PUNCT
admet-579	15	15	where	where	SCONJ
admet-579	15	16	fi	fi	NOUN
admet-579	15	17	is	be	AUX
admet-579	15	18	the	the	DET
admet-579	15	19	organ	organ	NOUN
admet-579	15	20	blood	blood	NOUN
admet-579	15	21	flow	flow	NOUN
admet-579	15	22	,	,	PUNCT
admet-579	15	23	ca(t	ca(t	PUNCT
admet-579	15	24	)	)	PUNCT
admet-579	15	25	is	be	AUX
admet-579	15	26	the	the	DET
admet-579	15	27	arterial	arterial	ADJ
admet-579	15	28	blood	blood	NOUN
admet-579	15	29	concentration	concentration	NOUN
admet-579	15	30	and	and	CCONJ
admet-579	15	31	ci(t	ci(t	NOUN
admet-579	15	32	)	)	PUNCT
admet-579	15	33	is	be	AUX
admet-579	15	34	the	the	DET
admet-579	15	35	venous	venous	ADJ
admet-579	15	36	blood	blood	NOUN
admet-579	15	37	concentration	concentration	NOUN
admet-579	15	38	leaving	leave	VERB
admet-579	15	39	the	the	DET
admet-579	15	40	organ	organ	NOUN
admet-579	15	41	and	and	CCONJ
admet-579	15	42	it	it	PRON
admet-579	15	43	is	be	AUX
admet-579	15	44	assumed	assume	VERB
admet-579	15	45	that	that	SCONJ
admet-579	15	46	the	the	DET
admet-579	15	47	free	free	ADJ
admet-579	15	48	,	,	PUNCT
admet-579	15	49	unbound	unbound	ADJ
admet-579	15	50	well	well	ADV
admet-579	15	51	-	-	PUNCT
admet-579	15	52	mixed	mix	VERB
admet-579	15	53	tissue	tissue	NOUN
admet-579	15	54	concentration	concentration	NOUN
admet-579	15	55	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-579	15	56	admet	admet	PROPN
admet-579	15	57	&	&	CCONJ
admet-579	15	58	dmpk	dmpk	PROPN
admet-579	15	59	7(1	7(1	PROPN
admet-579	15	60	)	)	PUNCT
admet-579	15	61	(	(	PUNCT
admet-579	15	62	2019	2019	NUM
admet-579	15	63	)	)	PUNCT
admet-579	15	64	60	60	NUM
admet-579	15	65	-	-	SYM
admet-579	15	66	75	75	NUM
admet-579	15	67	lipid	lipid	NOUN
admet-579	15	68	soluble	soluble	ADJ
admet-579	15	69	and	and	CCONJ
admet-579	15	70	extracellular	extracellular	ADJ
admet-579	15	71	solutes	solute	NOUN
admet-579	15	72	doi	doi	NOUN
admet-579	15	73	:	:	PUNCT
admet-579	15	74	10.5599	10.5599	NUM
admet-579	15	75	/	/	SYM
admet-579	15	76	admet.579	admet.579	NOUN
admet-579	15	77	61	61	NUM
admet-579	15	78	is	be	AUX
admet-579	15	79	equal	equal	ADJ
admet-579	15	80	to	to	ADP
admet-579	15	81	the	the	DET
admet-579	15	82	free	free	ADJ
admet-579	15	83	concentration	concentration	NOUN
admet-579	15	84	in	in	ADP
admet-579	15	85	the	the	DET
admet-579	15	86	venous	venous	ADJ
admet-579	15	87	blood	blood	NOUN
admet-579	15	88	of	of	ADP
admet-579	15	89	the	the	DET
admet-579	15	90	organ	organ	NOUN
admet-579	15	91	.	.	PUNCT
admet-579	16	1	all	all	DET
admet-579	16	2	the	the	DET
admet-579	16	3	complexity	complexity	NOUN
admet-579	16	4	is	be	AUX
admet-579	16	5	in	in	ADP
admet-579	16	6	the	the	DET
admet-579	16	7	parameter	parameter	NOUN
admet-579	16	8	v	v	ADP
admet-579	16	9	i	i	PRON
admet-579	16	10	which	which	PRON
admet-579	16	11	is	be	AUX
admet-579	16	12	the	the	DET
admet-579	16	13	organ	organ	NOUN
admet-579	16	14	“	"	PUNCT
admet-579	16	15	volume	volume	NOUN
admet-579	16	16	of	of	ADP
admet-579	16	17	distribution	distribution	NOUN
admet-579	16	18	”	"	PUNCT
admet-579	16	19	defined	define	VERB
admet-579	16	20	by	by	ADP
admet-579	16	21	:	:	PUNCT
admet-579	16	22	i	i	PRON
admet-579	16	23	i	i	PRON
admet-579	17	1	i	i	PRON
admet-579	17	2	i	i	PRON
admet-579	18	1	i	i	PRON
admet-579	18	2	i	i	PRON
admet-579	19	1	i	i	PRON
admet-579	19	2	i	i	PRON
admet-579	20	1	i	i	PRON
admet-579	20	2	i	i	VERB
admet-579	21	1	b	b	PROPN
admet-579	22	1	t	t	PROPN
admet-579	22	2	t	t	PROPN
admet-579	22	3	b	b	X
admet-579	22	4	t	t	PROPN
admet-579	23	1	i	i	PRON
admet-579	23	2	i	i	PRON
admet-579	24	1	i	i	PRON
admet-579	24	2	i	i	PRON
admet-579	24	3	b	b	NOUN
admet-579	24	4	t	t	NUM
admet-579	24	5	totalamountofsolute	totalamountofsolute	NOUN
admet-579	24	6	inorgan	inorgan	VERB
admet-579	24	7	i	i	PRON
admet-579	24	8	[	[	X
admet-579	24	9	]	]	X
admet-579	24	10	v	v	X
admet-579	24	11	v	v	NOUN
admet-579	24	12	c	c	NOUN
admet-579	24	13	v	v	NOUN
admet-579	24	14	c	c	NOUN
admet-579	24	15	v	v	NOUN
admet-579	24	16	c	c	NOUN
admet-579	24	17	c	c	NOUN
admet-579	24	18	v	v	NOUN
admet-579	24	19	k	k	PROPN
admet-579	24	20	v	v	X
admet-579	24	21	v	v	PROPN
admet-579	24	22	k	k	PROPN
admet-579	24	23	v	v	ADP
admet-579	24	24			PROPN
admet-579	24	25			PRON
admet-579	24	26			ADV
admet-579	25	1			NUM
admet-579	26	1			ADJ
admet-579	27	1			NOUN
admet-579	28	1			PROPN
admet-579	28	2			PUNCT
admet-579	28	3	(	(	PUNCT
admet-579	28	4	2	2	NUM
admet-579	28	5	)	)	PUNCT
admet-579	28	6	where	where	SCONJ
admet-579	28	7	vb	vb	NOUN
admet-579	28	8	i	i	PRON
admet-579	28	9	and	and	CCONJ
admet-579	28	10	vt	vt	PROPN
admet-579	28	11	i	i	PRON
admet-579	28	12	are	be	AUX
admet-579	28	13	the	the	DET
admet-579	28	14	anatomic	anatomic	ADJ
admet-579	28	15	blood	blood	NOUN
admet-579	28	16	and	and	CCONJ
admet-579	28	17	extravascular	extravascular	ADJ
admet-579	28	18	organ	organ	NOUN
admet-579	28	19	volumes	volume	NOUN
admet-579	28	20	,	,	PUNCT
admet-579	28	21	respectively	respectively	ADV
admet-579	28	22	,	,	PUNCT
admet-579	28	23	ct	ct	PRON
admet-579	28	24	i	i	PRON
admet-579	28	25	is	be	AUX
admet-579	28	26	the	the	DET
admet-579	28	27	tissue	tissue	NOUN
admet-579	28	28	concentration	concentration	NOUN
admet-579	28	29	and	and	CCONJ
admet-579	28	30	ki	ki	INTJ
admet-579	29	1	(=	(=	INTJ
admet-579	29	2	ct	ct	PROPN
admet-579	30	1	i	i	PROPN
admet-579	30	2	/	/	SYM
admet-579	30	3	ci	ci	NOUN
admet-579	30	4	)	)	PUNCT
admet-579	30	5	is	be	AUX
admet-579	30	6	the	the	DET
admet-579	30	7	tissue	tissue	NOUN
admet-579	30	8	/	/	SYM
admet-579	30	9	blood	blood	NOUN
admet-579	30	10	partition	partition	NOUN
admet-579	30	11	coefficient	coefficient	NOUN
admet-579	30	12	.	.	PUNCT
admet-579	31	1	the	the	DET
admet-579	31	2	organ	organ	NOUN
admet-579	31	3	blood	blood	NOUN
admet-579	31	4	flow	flow	NOUN
admet-579	31	5	(	(	PUNCT
admet-579	31	6	fi	fi	NOUN
admet-579	31	7	)	)	PUNCT
admet-579	31	8	and	and	CCONJ
admet-579	31	9	the	the	DET
admet-579	31	10	blood	blood	NOUN
admet-579	31	11	(	(	PUNCT
admet-579	31	12	vb	vb	NOUN
admet-579	31	13	i	i	PROPN
admet-579	31	14	)	)	PUNCT
admet-579	31	15	and	and	CCONJ
admet-579	31	16	tissue	tissue	NOUN
admet-579	31	17	(	(	PUNCT
admet-579	31	18	vt	vt	NOUN
admet-579	31	19	i	i	PROPN
admet-579	31	20	)	)	PUNCT
admet-579	31	21	volumes	volume	NOUN
admet-579	31	22	can	can	AUX
admet-579	31	23	be	be	AUX
admet-579	31	24	accurately	accurately	ADV
admet-579	31	25	estimated	estimate	VERB
admet-579	31	26	from	from	ADP
admet-579	31	27	prior	prior	ADJ
admet-579	31	28	human	human	ADJ
admet-579	31	29	physiological	physiological	ADJ
admet-579	31	30	and	and	CCONJ
admet-579	31	31	anatomic	anatomic	ADJ
admet-579	31	32	measurements	measurement	NOUN
admet-579	31	33	.	.	PUNCT
admet-579	32	1	however	however	ADV
admet-579	32	2	,	,	PUNCT
admet-579	32	3	k	k	PROPN
admet-579	32	4	i	i	PROPN
admet-579	32	5	,	,	PUNCT
admet-579	32	6	which	which	PRON
admet-579	32	7	depends	depend	VERB
admet-579	32	8	on	on	ADP
admet-579	32	9	the	the	DET
admet-579	32	10	specific	specific	ADJ
admet-579	32	11	physicochemical	physicochemical	ADJ
admet-579	32	12	properties	property	NOUN
admet-579	32	13	of	of	ADP
admet-579	32	14	the	the	DET
admet-579	32	15	solute	solute	NOUN
admet-579	32	16	and	and	CCONJ
admet-579	32	17	varies	vary	VERB
admet-579	32	18	from	from	ADP
admet-579	32	19	values	value	NOUN
admet-579	32	20	of	of	ADP
admet-579	32	21	0.2	0.2	NUM
admet-579	32	22	or	or	CCONJ
admet-579	32	23	less	less	ADJ
admet-579	32	24	to	to	ADP
admet-579	32	25	greater	great	ADJ
admet-579	32	26	than	than	ADP
admet-579	32	27	100	100	NUM
admet-579	32	28	,	,	PUNCT
admet-579	32	29	dominates	dominate	VERB
admet-579	32	30	the	the	DET
admet-579	32	31	kinetics	kinetic	NOUN
admet-579	32	32	and	and	CCONJ
admet-579	32	33	is	be	AUX
admet-579	32	34	the	the	DET
admet-579	32	35	major	major	ADJ
admet-579	32	36	uncertainty	uncertainty	NOUN
admet-579	32	37	and	and	CCONJ
admet-579	32	38	limitation	limitation	NOUN
admet-579	32	39	of	of	ADP
admet-579	32	40	pbpk	pbpk	ADJ
admet-579	32	41	analysis	analysis	NOUN
admet-579	32	42	.	.	PUNCT
admet-579	33	1	in	in	ADP
admet-579	33	2	general	general	ADJ
admet-579	33	3	,	,	PUNCT
admet-579	33	4	for	for	ADP
admet-579	33	5	an	an	DET
admet-579	33	6	accurate	accurate	ADJ
admet-579	33	7	pbpk	pbpk	NOUN
admet-579	33	8	analysis	analysis	NOUN
admet-579	33	9	it	it	PRON
admet-579	33	10	is	be	AUX
admet-579	33	11	necessary	necessary	ADJ
admet-579	33	12	to	to	PART
admet-579	33	13	determine	determine	VERB
admet-579	33	14	the	the	DET
admet-579	33	15	k	k	PROPN
admet-579	33	16	i	i	PRON
admet-579	33	17	for	for	ADP
admet-579	33	18	the	the	DET
admet-579	33	19	solute	solute	NOUN
admet-579	33	20	of	of	ADP
admet-579	33	21	interest	interest	NOUN
admet-579	33	22	from	from	ADP
admet-579	33	23	complex	complex	ADJ
admet-579	33	24	animal	animal	NOUN
admet-579	33	25	(	(	PUNCT
admet-579	33	26	usually	usually	ADV
admet-579	33	27	rat	rat	NOUN
admet-579	33	28	)	)	PUNCT
admet-579	33	29	tissue	tissue	NOUN
admet-579	33	30	measurements	measurement	NOUN
admet-579	33	31	and	and	CCONJ
admet-579	33	32	then	then	ADV
admet-579	33	33	assume	assume	VERB
admet-579	33	34	(	(	PUNCT
admet-579	33	35	hope	hope	NOUN
admet-579	33	36	)	)	PUNCT
admet-579	33	37	that	that	SCONJ
admet-579	33	38	the	the	DET
admet-579	33	39	rat	rat	NOUN
admet-579	33	40	values	value	NOUN
admet-579	33	41	can	can	AUX
admet-579	33	42	be	be	AUX
admet-579	33	43	extrapolated	extrapolate	VERB
admet-579	33	44	to	to	ADP
admet-579	33	45	the	the	DET
admet-579	33	46	human	human	NOUN
admet-579	33	47	.	.	PUNCT
admet-579	34	1	ideally	ideally	ADV
admet-579	34	2	,	,	PUNCT
admet-579	34	3	one	one	PRON
admet-579	34	4	would	would	AUX
admet-579	34	5	like	like	VERB
admet-579	34	6	to	to	PART
admet-579	34	7	be	be	AUX
admet-579	34	8	able	able	ADJ
admet-579	34	9	to	to	PART
admet-579	34	10	predict	predict	VERB
admet-579	34	11	ki	ki	PROPN
admet-579	34	12	just	just	ADV
admet-579	34	13	based	base	VERB
admet-579	34	14	on	on	ADP
admet-579	34	15	its	its	PRON
admet-579	34	16	chemical	chemical	NOUN
admet-579	34	17	structure	structure	NOUN
admet-579	34	18	,	,	PUNCT
admet-579	34	19	allowing	allow	VERB
admet-579	34	20	one	one	NOUN
admet-579	34	21	to	to	PART
admet-579	34	22	determine	determine	VERB
admet-579	34	23	a	a	DET
admet-579	34	24	drug	drug	NOUN
admet-579	34	25	’s	’s	PART
admet-579	34	26	detailed	detailed	ADJ
admet-579	34	27	pk	pk	NOUN
admet-579	34	28	a	a	X
admet-579	34	29	priori	priori	ADV
admet-579	34	30	.	.	PUNCT
admet-579	35	1	unfortunately	unfortunately	ADV
admet-579	35	2	,	,	PUNCT
admet-579	35	3	for	for	ADP
admet-579	35	4	the	the	DET
admet-579	35	5	majority	majority	NOUN
admet-579	35	6	of	of	ADP
admet-579	35	7	drugs	drug	NOUN
admet-579	35	8	that	that	PRON
admet-579	35	9	are	be	AUX
admet-579	35	10	weak	weak	ADJ
admet-579	35	11	acids	acid	NOUN
admet-579	35	12	or	or	CCONJ
admet-579	35	13	bases	basis	NOUN
admet-579	35	14	,	,	PUNCT
admet-579	35	15	it	it	PRON
admet-579	35	16	is	be	AUX
admet-579	35	17	not	not	PART
admet-579	35	18	,	,	PUNCT
admet-579	35	19	as	as	ADV
admet-579	35	20	yet	yet	ADV
admet-579	35	21	,	,	PUNCT
admet-579	35	22	possible	possible	ADJ
admet-579	35	23	to	to	PART
admet-579	35	24	predict	predict	VERB
admet-579	35	25	ki	ki	PROPN
admet-579	35	26	accurately	accurately	ADV
admet-579	35	27	enough	enough	ADV
admet-579	35	28	to	to	PART
admet-579	35	29	meet	meet	VERB
admet-579	35	30	this	this	DET
admet-579	35	31	ideal	ideal	NOUN
admet-579	35	32	.	.	PUNCT
admet-579	36	1	the	the	DET
admet-579	36	2	current	current	ADJ
admet-579	36	3	state	state	NOUN
admet-579	36	4	of	of	ADP
admet-579	36	5	the	the	DET
admet-579	36	6	art	art	NOUN
admet-579	36	7	in	in	ADP
admet-579	36	8	predicting	predict	VERB
admet-579	36	9	k	k	PROPN
admet-579	36	10	i	i	PRON
admet-579	36	11	is	be	AUX
admet-579	36	12	illustrated	illustrate	VERB
admet-579	36	13	by	by	ADP
admet-579	36	14	the	the	DET
admet-579	36	15	algorithm	algorithm	NOUN
admet-579	36	16	developed	develop	VERB
admet-579	36	17	by	by	ADP
admet-579	36	18	poulin	poulin	PROPN
admet-579	36	19	and	and	CCONJ
admet-579	36	20	colleagues	colleague	NOUN
admet-579	36	21	over	over	ADP
admet-579	36	22	many	many	ADJ
admet-579	36	23	years	year	NOUN
admet-579	36	24	of	of	ADP
admet-579	36	25	analysis	analysis	NOUN
admet-579	36	26	[	[	X
admet-579	36	27	2	2	NUM
admet-579	36	28	]	]	PUNCT
admet-579	36	29	.	.	PUNCT
admet-579	37	1	about	about	ADV
admet-579	37	2	50	50	NUM
admet-579	37	3	%	%	NOUN
admet-579	37	4	of	of	ADP
admet-579	37	5	the	the	DET
admet-579	37	6	predictions	prediction	NOUN
admet-579	37	7	are	be	AUX
admet-579	37	8	accurate	accurate	ADJ
admet-579	37	9	to	to	ADP
admet-579	37	10	within	within	ADP
admet-579	37	11	a	a	DET
admet-579	37	12	factor	factor	NOUN
admet-579	37	13	of	of	ADP
admet-579	37	14	2	2	NUM
admet-579	37	15	,	,	PUNCT
admet-579	37	16	with	with	ADP
admet-579	37	17	about	about	ADV
admet-579	37	18	15	15	NUM
admet-579	37	19	%	%	NOUN
admet-579	37	20	of	of	ADP
admet-579	37	21	the	the	DET
admet-579	37	22	predictions	prediction	NOUN
admet-579	37	23	off	off	ADP
admet-579	37	24	by	by	ADP
admet-579	37	25	a	a	DET
admet-579	37	26	factor	factor	NOUN
admet-579	37	27	of	of	ADP
admet-579	37	28	greater	great	ADJ
admet-579	37	29	than	than	ADP
admet-579	37	30	3	3	NUM
admet-579	37	31	fold	fold	NOUN
admet-579	37	32	.	.	PUNCT
admet-579	38	1	although	although	SCONJ
admet-579	38	2	this	this	DET
admet-579	38	3	level	level	NOUN
admet-579	38	4	of	of	ADP
admet-579	38	5	accuracy	accuracy	NOUN
admet-579	38	6	is	be	AUX
admet-579	38	7	useful	useful	ADJ
admet-579	38	8	for	for	ADP
admet-579	38	9	,	,	PUNCT
admet-579	38	10	eg	eg	NOUN
admet-579	38	11	,	,	PUNCT
admet-579	38	12	predicting	predict	VERB
admet-579	38	13	preliminary	preliminary	ADJ
admet-579	38	14	dosage	dosage	NOUN
admet-579	38	15	levels	level	NOUN
admet-579	38	16	for	for	ADP
admet-579	38	17	a	a	DET
admet-579	38	18	trial	trial	NOUN
admet-579	38	19	drug	drug	NOUN
admet-579	38	20	,	,	PUNCT
admet-579	38	21	it	it	PRON
admet-579	38	22	severely	severely	ADV
admet-579	38	23	limits	limit	VERB
admet-579	38	24	the	the	DET
admet-579	38	25	value	value	NOUN
admet-579	38	26	of	of	ADP
admet-579	38	27	pbpk	pbpk	ADJ
admet-579	38	28	predictions	prediction	NOUN
admet-579	38	29	because	because	SCONJ
admet-579	38	30	they	they	PRON
admet-579	38	31	are	be	AUX
admet-579	38	32	unlikely	unlikely	ADJ
admet-579	38	33	to	to	PART
admet-579	38	34	be	be	AUX
admet-579	38	35	superior	superior	ADJ
admet-579	38	36	to	to	ADP
admet-579	38	37	those	those	PRON
admet-579	38	38	made	make	VERB
admet-579	38	39	using	use	VERB
admet-579	38	40	just	just	ADV
admet-579	38	41	a	a	DET
admet-579	38	42	simple	simple	ADJ
admet-579	38	43	1	1	NUM
admet-579	38	44	-	-	PUNCT
admet-579	38	45	compartment	compartment	NOUN
admet-579	38	46	model	model	NOUN
admet-579	38	47	based	base	VERB
admet-579	38	48	just	just	ADV
admet-579	38	49	on	on	ADP
admet-579	38	50	the	the	DET
admet-579	38	51	standard	standard	ADJ
admet-579	38	52	pharmacokinetic	pharmacokinetic	ADJ
admet-579	38	53	(	(	PUNCT
admet-579	38	54	pk	pk	NOUN
admet-579	38	55	)	)	PUNCT
admet-579	38	56	measurements	measurement	NOUN
admet-579	38	57	of	of	ADP
admet-579	38	58	clearance	clearance	NOUN
admet-579	38	59	and	and	CCONJ
admet-579	38	60	volume	volume	NOUN
admet-579	38	61	of	of	ADP
admet-579	38	62	distribution	distribution	NOUN
admet-579	38	63	.	.	PUNCT
admet-579	39	1	however	however	ADV
admet-579	39	2	,	,	PUNCT
admet-579	39	3	there	there	PRON
admet-579	39	4	are	be	VERB
admet-579	39	5	two	two	NUM
admet-579	39	6	major	major	ADJ
admet-579	39	7	exceptions	exception	NOUN
admet-579	39	8	to	to	ADP
admet-579	39	9	this	this	DET
admet-579	39	10	limitation	limitation	NOUN
admet-579	39	11	:	:	PUNCT
admet-579	39	12	the	the	DET
admet-579	39	13	highly	highly	ADV
admet-579	39	14	lipid	lipid	ADJ
admet-579	39	15	soluble	soluble	ADJ
admet-579	39	16	(	(	PUNCT
admet-579	39	17	hls	hls	NOUN
admet-579	39	18	)	)	PUNCT
admet-579	39	19	and	and	CCONJ
admet-579	39	20	the	the	DET
admet-579	39	21	extracellular	extracellular	ADJ
admet-579	39	22	drugs	drug	NOUN
admet-579	39	23	(	(	PUNCT
admet-579	39	24	ecs	ec	NOUN
admet-579	39	25	)	)	PUNCT
admet-579	39	26	.	.	PUNCT
admet-579	40	1	the	the	DET
admet-579	40	2	hls	hls	PROPN
admet-579	40	3	drugs	drug	NOUN
admet-579	40	4	(	(	PUNCT
admet-579	40	5	volatile	volatile	ADJ
admet-579	40	6	anesthetics	anesthetic	NOUN
admet-579	40	7	,	,	PUNCT
admet-579	40	8	propofol	propofol	NOUN
admet-579	40	9	,	,	PUNCT
admet-579	40	10	cannabinol	cannabinol	NOUN
admet-579	40	11	,	,	PUNCT
admet-579	40	12	etc	etc	X
admet-579	40	13	.	.	X
admet-579	40	14	)	)	PUNCT
admet-579	40	15	have	have	VERB
admet-579	40	16	lipid	lipid	NOUN
admet-579	40	17	/	/	SYM
admet-579	40	18	water	water	NOUN
admet-579	40	19	partition	partition	NOUN
admet-579	40	20	coefficients	coefficient	NOUN
admet-579	40	21	(	(	PUNCT
admet-579	40	22	pl	pl	NOUN
admet-579	40	23	/	/	SYM
admet-579	40	24	w	w	NOUN
admet-579	40	25	)	)	PUNCT
admet-579	40	26	of	of	ADP
admet-579	40	27	100	100	NUM
admet-579	40	28	or	or	CCONJ
admet-579	40	29	greater	great	ADJ
admet-579	40	30	and	and	CCONJ
admet-579	40	31	their	their	PRON
admet-579	40	32	k	k	NOUN
admet-579	40	33	i	i	PRON
admet-579	40	34	is	be	AUX
admet-579	40	35	dominated	dominate	VERB
admet-579	40	36	by	by	ADP
admet-579	40	37	the	the	DET
admet-579	40	38	tissue	tissue	NOUN
admet-579	40	39	fat	fat	ADJ
admet-579	40	40	fraction	fraction	NOUN
admet-579	40	41	[	[	X
admet-579	40	42	1	1	NUM
admet-579	40	43	]	]	PUNCT
admet-579	40	44	.	.	PUNCT
admet-579	41	1	this	this	PRON
admet-579	41	2	means	mean	VERB
admet-579	41	3	that	that	SCONJ
admet-579	41	4	one	one	PRON
admet-579	41	5	can	can	AUX
admet-579	41	6	predict	predict	VERB
admet-579	41	7	the	the	DET
admet-579	41	8	ki	ki	PROPN
admet-579	41	9	just	just	ADV
admet-579	41	10	from	from	ADP
admet-579	41	11	in	in	ADP
admet-579	41	12	vitro	vitro	X
admet-579	41	13	measurements	measurement	NOUN
admet-579	41	14	of	of	ADP
admet-579	41	15	pl	pl	PROPN
admet-579	41	16	/	/	SYM
admet-579	41	17	w	w	NOUN
admet-579	41	18	along	along	ADP
admet-579	41	19	with	with	ADP
admet-579	41	20	previous	previous	ADJ
admet-579	41	21	measurements	measurement	NOUN
admet-579	41	22	of	of	ADP
admet-579	41	23	the	the	DET
admet-579	41	24	fat	fat	ADJ
admet-579	41	25	fraction	fraction	NOUN
admet-579	41	26	of	of	ADP
admet-579	41	27	all	all	DET
admet-579	41	28	the	the	DET
admet-579	41	29	tissues	tissue	NOUN
admet-579	41	30	in	in	ADP
admet-579	41	31	the	the	DET
admet-579	41	32	pbpk	pbpk	ADJ
admet-579	41	33	model	model	NOUN
admet-579	41	34	(	(	PUNCT
admet-579	41	35	see	see	VERB
admet-579	41	36	fig	fig	NOUN
admet-579	41	37	.	.	PUNCT
admet-579	42	1	1	1	NUM
admet-579	42	2	)	)	PUNCT
admet-579	42	3	.	.	PUNCT
admet-579	43	1	the	the	DET
admet-579	43	2	ecs	ecs	PROPN
admet-579	43	3	drugs	drug	NOUN
admet-579	43	4	,	,	PUNCT
admet-579	43	5	such	such	ADJ
admet-579	43	6	as	as	ADP
admet-579	43	7	most	most	ADJ
admet-579	43	8	antibiotics	antibiotic	NOUN
admet-579	43	9	,	,	PUNCT
admet-579	43	10	can	can	AUX
admet-579	43	11	not	not	PART
admet-579	43	12	penetrate	penetrate	VERB
admet-579	43	13	cells	cell	NOUN
admet-579	43	14	,	,	PUNCT
admet-579	43	15	and	and	CCONJ
admet-579	43	16	therefore	therefore	ADV
admet-579	43	17	are	be	AUX
admet-579	43	18	not	not	PART
admet-579	43	19	subject	subject	ADJ
admet-579	43	20	to	to	ADP
admet-579	43	21	the	the	DET
admet-579	43	22	intracellular	intracellular	ADJ
admet-579	43	23	binding	binding	NOUN
admet-579	43	24	that	that	PRON
admet-579	43	25	complicates	complicate	VERB
admet-579	43	26	the	the	DET
admet-579	43	27	prediction	prediction	NOUN
admet-579	43	28	of	of	ADP
admet-579	43	29	ki	ki	PROPN
admet-579	43	30	for	for	ADP
admet-579	43	31	the	the	DET
admet-579	43	32	weak	weak	ADJ
admet-579	43	33	bases	basis	NOUN
admet-579	43	34	and	and	CCONJ
admet-579	43	35	acids	acid	NOUN
admet-579	43	36	.	.	PUNCT
admet-579	44	1	the	the	DET
admet-579	44	2	ki	ki	PROPN
admet-579	44	3	of	of	ADP
admet-579	44	4	most	most	ADJ
admet-579	44	5	ecs	ec	NOUN
admet-579	44	6	drugs	drug	NOUN
admet-579	44	7	is	be	AUX
admet-579	44	8	determined	determine	VERB
admet-579	44	9	primarily	primarily	ADV
admet-579	44	10	by	by	ADP
admet-579	44	11	the	the	DET
admet-579	44	12	volume	volume	NOUN
admet-579	44	13	and	and	CCONJ
admet-579	44	14	albumin	albumin	ADJ
admet-579	44	15	concentration	concentration	NOUN
admet-579	44	16	in	in	ADP
admet-579	44	17	the	the	DET
admet-579	44	18	interstitial	interstitial	ADJ
admet-579	44	19	space	space	NOUN
admet-579	44	20	and	and	CCONJ
admet-579	44	21	the	the	DET
admet-579	44	22	albumin	albumin	ADJ
admet-579	44	23	binding	bind	VERB
admet-579	44	24	affinity	affinity	NOUN
admet-579	44	25	.	.	PUNCT
admet-579	45	1	thus	thus	ADV
admet-579	45	2	,	,	PUNCT
admet-579	45	3	the	the	DET
admet-579	45	4	ecs	ecs	PROPN
admet-579	45	5	ki	ki	PROPN
admet-579	45	6	can	can	AUX
admet-579	45	7	be	be	AUX
admet-579	45	8	predicted	predict	VERB
admet-579	45	9	from	from	ADP
admet-579	45	10	prior	prior	ADJ
admet-579	45	11	measurements	measurement	NOUN
admet-579	45	12	of	of	ADP
admet-579	45	13	tissue	tissue	NOUN
admet-579	45	14	interstitial	interstitial	ADJ
admet-579	45	15	volumes	volume	NOUN
admet-579	45	16	and	and	CCONJ
admet-579	45	17	albumin	albumin	ADJ
admet-579	45	18	concentrations	concentration	NOUN
admet-579	45	19	and	and	CCONJ
admet-579	45	20	in	in	ADP
admet-579	45	21	vitro	vitro	X
admet-579	45	22	measurements	measurement	NOUN
admet-579	45	23	of	of	ADP
admet-579	45	24	albumin	albumin	ADJ
admet-579	45	25	binding	bind	VERB
admet-579	45	26	affinity	affinity	NOUN
admet-579	45	27	.	.	PUNCT
admet-579	46	1	pkquest	pkquest	PROPN
admet-579	46	2	is	be	AUX
admet-579	46	3	a	a	DET
admet-579	46	4	freely	freely	ADV
admet-579	46	5	distributed	distribute	VERB
admet-579	46	6	(	(	PUNCT
admet-579	46	7	www.pkquest.com	www.pkquest.com	NOUN
admet-579	46	8	)	)	PUNCT
admet-579	46	9	,	,	PUNCT
admet-579	46	10	java	java	PROPN
admet-579	46	11	based	base	VERB
admet-579	46	12	,	,	PUNCT
admet-579	46	13	pk	pk	NOUN
admet-579	46	14	and	and	CCONJ
admet-579	46	15	pbpk	pbpk	PROPN
admet-579	46	16	program	program	NOUN
admet-579	46	17	.	.	PUNCT
admet-579	47	1	the	the	DET
admet-579	47	2	major	major	ADJ
admet-579	47	3	effort	effort	NOUN
admet-579	47	4	in	in	ADP
admet-579	47	5	its	its	PRON
admet-579	47	6	design	design	NOUN
admet-579	47	7	has	have	AUX
admet-579	47	8	been	be	AUX
admet-579	47	9	to	to	PART
admet-579	47	10	provide	provide	VERB
admet-579	47	11	a	a	DET
admet-579	47	12	user	user	NOUN
admet-579	47	13	interface	interface	NOUN
admet-579	47	14	that	that	PRON
admet-579	47	15	is	be	AUX
admet-579	47	16	both	both	PRON
admet-579	47	17	simple	simple	ADJ
admet-579	47	18	enough	enough	ADV
admet-579	47	19	to	to	PART
admet-579	47	20	be	be	AUX
admet-579	47	21	used	use	VERB
admet-579	47	22	by	by	ADP
admet-579	47	23	students	student	NOUN
admet-579	47	24	as	as	ADP
admet-579	47	25	an	an	DET
admet-579	47	26	adjunct	adjunct	ADJ
admet-579	47	27	in	in	ADP
admet-579	47	28	pk	pk	NOUN
admet-579	47	29	courses	course	NOUN
admet-579	47	30	and	and	CCONJ
admet-579	47	31	general	general	ADJ
admet-579	47	32	enough	enough	ADV
admet-579	47	33	to	to	PART
admet-579	47	34	be	be	AUX
admet-579	47	35	applicable	applicable	ADJ
admet-579	47	36	to	to	ADP
admet-579	47	37	most	most	ADJ
admet-579	47	38	pk	pk	NOUN
admet-579	47	39	and	and	CCONJ
admet-579	47	40	pbpk	pbpk	NOUN
admet-579	47	41	applications	application	NOUN
admet-579	47	42	.	.	PUNCT
admet-579	48	1	since	since	SCONJ
admet-579	48	2	its	its	PRON
admet-579	48	3	introduction	introduction	NOUN
admet-579	48	4	in	in	ADP
admet-579	48	5	2002	2002	NUM
admet-579	48	6	,	,	PUNCT
admet-579	48	7	pkquest	pkquest	NOUN
admet-579	48	8	has	have	AUX
admet-579	48	9	been	be	AUX
admet-579	48	10	applied	apply	VERB
admet-579	48	11	to	to	ADP
admet-579	48	12	hundreds	hundred	NOUN
admet-579	48	13	of	of	ADP
admet-579	48	14	solutes	solute	NOUN
admet-579	48	15	described	describe	VERB
admet-579	48	16	in	in	ADP
admet-579	48	17	more	more	ADJ
admet-579	48	18	than	than	ADP
admet-579	48	19	11	11	NUM
admet-579	48	20	publications	publication	NOUN
admet-579	48	21	[	[	X
admet-579	48	22	3	3	NUM
admet-579	48	23	-	-	SYM
admet-579	48	24	13	13	NUM
admet-579	48	25	]	]	PUNCT
admet-579	48	26	.	.	PUNCT
admet-579	49	1	recently	recently	ADV
admet-579	49	2	,	,	PUNCT
admet-579	49	3	a	a	DET
admet-579	49	4	freely	freely	ADV
admet-579	49	5	distributed	distribute	VERB
admet-579	49	6	textbook	textbook	NOUN
admet-579	49	7	(	(	PUNCT
admet-579	49	8	“	"	PUNCT
admet-579	49	9	computer	computer	NOUN
admet-579	49	10	assisted	assist	VERB
admet-579	49	11	human	human	ADJ
admet-579	49	12	pharmacokinetics	pharmacokinetic	NOUN
admet-579	49	13	”	"	PUNCT
admet-579	49	14	)	)	PUNCT
admet-579	49	15	has	have	AUX
admet-579	49	16	been	be	AUX
admet-579	49	17	developed	develop	VERB
admet-579	49	18	that	that	PRON
admet-579	49	19	covers	cover	VERB
admet-579	49	20	most	most	ADJ
admet-579	49	21	pk	pk	NOUN
admet-579	49	22	topics	topic	NOUN
admet-579	49	23	and	and	CCONJ
admet-579	49	24	is	be	AUX
admet-579	49	25	closely	closely	ADV
admet-579	49	26	integrated	integrate	VERB
admet-579	49	27	with	with	ADP
admet-579	49	28	pkquest[1	pkquest[1	NOUN
admet-579	49	29	]	]	PUNCT
admet-579	49	30	.	.	PUNCT
admet-579	50	1	pkquest	pkquest	PROPN
admet-579	50	2	implements	implement	VERB
admet-579	50	3	the	the	DET
admet-579	50	4	standard	standard	ADJ
admet-579	50	5	pbpk	pbpk	ADJ
admet-579	50	6	approach	approach	NOUN
admet-579	50	7	.	.	PUNCT
admet-579	51	1	the	the	DET
admet-579	51	2	body	body	NOUN
admet-579	51	3	is	be	AUX
admet-579	51	4	divided	divide	VERB
admet-579	51	5	into	into	ADP
admet-579	51	6	14	14	NUM
admet-579	51	7	“	"	PUNCT
admet-579	51	8	tissue	tissue	NOUN
admet-579	51	9	”	"	PUNCT
admet-579	51	10	compartments	compartment	NOUN
admet-579	51	11	(	(	PUNCT
admet-579	51	12	fig	fig	NOUN
admet-579	51	13	.	.	NOUN
admet-579	51	14	1	1	NUM
admet-579	51	15	)	)	PUNCT
admet-579	51	16	,	,	PUNCT
admet-579	51	17	each	each	PRON
admet-579	51	18	of	of	ADP
admet-579	51	19	which	which	PRON
admet-579	51	20	is	be	AUX
admet-579	51	21	described	describe	VERB
admet-579	51	22	by	by	ADP
admet-579	51	23	eqs	eqs	PROPN
admet-579	51	24	.	.	PUNCT
admet-579	52	1	(	(	PUNCT
admet-579	52	2	1	1	X
admet-579	52	3	)	)	PUNCT
admet-579	52	4	and	and	CCONJ
admet-579	52	5	(	(	PUNCT
admet-579	52	6	2	2	NUM
admet-579	52	7	)	)	PUNCT
admet-579	52	8	and	and	CCONJ
admet-579	52	9	three	three	NUM
admet-579	52	10	“	"	PUNCT
admet-579	52	11	tissue	tissue	NOUN
admet-579	52	12	”	"	PUNCT
admet-579	52	13	parameters	parameter	NOUN
admet-579	52	14	(	(	PUNCT
admet-579	52	15	vt	vt	NOUN
admet-579	52	16	i	i	PROPN
admet-579	52	17	,	,	PUNCT
admet-579	52	18	fi	fi	NOUN
admet-579	52	19	,	,	PUNCT
admet-579	52	20	and	and	CCONJ
admet-579	52	21	ki	ki	PROPN
admet-579	52	22	)	)	PUNCT
admet-579	52	23	.	.	PUNCT
admet-579	53	1	for	for	ADP
admet-579	53	2	a	a	DET
admet-579	53	3	given	give	VERB
admet-579	53	4	solute	solute	NOUN
admet-579	53	5	input	input	NOUN
admet-579	53	6	(	(	PUNCT
admet-579	53	7	oral	oral	ADJ
admet-579	53	8	,	,	PUNCT
admet-579	53	9	iv	iv	NOUN
admet-579	53	10	,	,	PUNCT
admet-579	53	11	etc	etc	X
admet-579	53	12	.	.	X
admet-579	53	13	)	)	PUNCT
admet-579	54	1	the	the	DET
admet-579	54	2	set	set	NOUN
admet-579	54	3	of	of	ADP
admet-579	54	4	equations	equation	NOUN
admet-579	54	5	is	be	AUX
admet-579	54	6	solved	solve	VERB
admet-579	54	7	numerically	numerically	ADV
admet-579	54	8	,	,	PUNCT
admet-579	54	9	and	and	CCONJ
admet-579	54	10	a	a	DET
admet-579	54	11	plot	plot	NOUN
admet-579	54	12	of	of	ADP
admet-579	54	13	the	the	DET
admet-579	54	14	time	time	NOUN
admet-579	54	15	http://www.pkquest.com/	http://www.pkquest.com/	NOUN
admet-579	54	16	david	david	PROPN
admet-579	54	17	levitt	levitt	PROPN
admet-579	54	18	admet	admet	PROPN
admet-579	54	19	&	&	CCONJ
admet-579	54	20	dmpk	dmpk	PROPN
admet-579	54	21	7(1	7(1	PROPN
admet-579	54	22	)	)	PUNCT
admet-579	54	23	(	(	PUNCT
admet-579	54	24	2019)60	2019)60	NUM
admet-579	54	25	-	-	SYM
admet-579	54	26	75	75	NUM
admet-579	54	27	62	62	NUM
admet-579	54	28	dependent	dependent	ADJ
admet-579	54	29	solute	solute	NOUN
admet-579	54	30	concentration	concentration	NOUN
admet-579	54	31	for	for	ADP
admet-579	54	32	each	each	PRON
admet-579	54	33	of	of	ADP
admet-579	54	34	the	the	DET
admet-579	54	35	organs	organ	NOUN
admet-579	54	36	is	be	AUX
admet-579	54	37	plotted	plot	VERB
admet-579	54	38	.	.	PUNCT
admet-579	55	1	usually	usually	ADV
admet-579	55	2	,	,	PUNCT
admet-579	55	3	of	of	ADP
admet-579	55	4	particular	particular	ADJ
admet-579	55	5	interest	interest	NOUN
admet-579	55	6	,	,	PUNCT
admet-579	55	7	is	be	AUX
admet-579	55	8	the	the	DET
admet-579	55	9	time	time	NOUN
admet-579	55	10	dependence	dependence	NOUN
admet-579	55	11	of	of	ADP
admet-579	55	12	the	the	DET
admet-579	55	13	concentration	concentration	NOUN
admet-579	55	14	in	in	ADP
admet-579	55	15	the	the	DET
admet-579	55	16	“	"	PUNCT
admet-579	55	17	vein	vein	ADJ
admet-579	55	18	”	"	PUNCT
admet-579	55	19	compartment	compartment	NOUN
admet-579	55	20	.	.	PUNCT
admet-579	56	1	figure	figure	NOUN
admet-579	56	2	1	1	NUM
admet-579	56	3	.	.	PUNCT
admet-579	56	4	pbpk	pbpk	PROPN
admet-579	56	5	model	model	NOUN
admet-579	56	6	used	use	VERB
admet-579	56	7	in	in	ADP
admet-579	56	8	pkquest	pkquest	NOUN
admet-579	56	9	.	.	PUNCT
admet-579	57	1	the	the	DET
admet-579	57	2	body	body	NOUN
admet-579	57	3	is	be	AUX
admet-579	57	4	modeled	model	VERB
admet-579	57	5	by	by	ADP
admet-579	57	6	12	12	NUM
admet-579	57	7	tissue	tissue	NOUN
admet-579	57	8	regions	region	NOUN
admet-579	57	9	,	,	PUNCT
admet-579	57	10	arranged	arrange	VERB
admet-579	57	11	in	in	ADP
admet-579	57	12	parallel	parallel	NOUN
admet-579	57	13	(	(	PUNCT
admet-579	57	14	except	except	SCONJ
admet-579	57	15	for	for	ADP
admet-579	57	16	the	the	DET
admet-579	57	17	“	"	PUNCT
admet-579	57	18	portal	portal	ADJ
admet-579	57	19	”	"	PUNCT
admet-579	57	20	and	and	CCONJ
admet-579	57	21	“	"	PUNCT
admet-579	57	22	lung	lung	NOUN
admet-579	57	23	”	"	PUNCT
admet-579	57	24	tissue	tissue	NOUN
admet-579	57	25	which	which	PRON
admet-579	57	26	are	be	AUX
admet-579	57	27	in	in	ADP
admet-579	57	28	series	series	NOUN
admet-579	57	29	)	)	PUNCT
admet-579	57	30	connected	connect	VERB
admet-579	57	31	by	by	ADP
admet-579	57	32	the	the	DET
admet-579	57	33	“	"	PUNCT
admet-579	57	34	vein	vein	NOUN
admet-579	57	35	”	"	PUNCT
admet-579	57	36	and	and	CCONJ
admet-579	57	37	“	"	PUNCT
admet-579	57	38	artery	artery	NOUN
admet-579	57	39	”	"	PUNCT
admet-579	57	40	compartments	compartment	NOUN
admet-579	57	41	.	.	PUNCT
admet-579	58	1	the	the	DET
admet-579	58	2	tissue	tissue	NOUN
admet-579	58	3	“	"	PUNCT
admet-579	58	4	portal	portal	ADJ
admet-579	58	5	”	"	PUNCT
admet-579	58	6	refers	refer	VERB
admet-579	58	7	to	to	ADP
admet-579	58	8	the	the	DET
admet-579	58	9	stomach	stomach	NOUN
admet-579	58	10	,	,	PUNCT
admet-579	58	11	small	small	ADJ
admet-579	58	12	and	and	CCONJ
admet-579	58	13	large	large	ADJ
admet-579	58	14	intestine	intestine	NOUN
admet-579	58	15	,	,	PUNCT
admet-579	58	16	spleen	spleen	NOUN
admet-579	58	17	and	and	CCONJ
admet-579	58	18	pancreatic	pancreatic	ADJ
admet-579	58	19	organs	organ	NOUN
admet-579	58	20	.	.	PUNCT
admet-579	59	1	the	the	DET
admet-579	59	2	tissue	tissue	NOUN
admet-579	59	3	parameters	parameter	NOUN
admet-579	59	4	are	be	AUX
admet-579	59	5	listed	list	VERB
admet-579	59	6	in	in	ADP
admet-579	59	7	table	table	NOUN
admet-579	59	8	1	1	NUM
admet-579	59	9	.	.	PUNCT
admet-579	60	1	in	in	ADP
admet-579	60	2	general	general	ADJ
admet-579	60	3	,	,	PUNCT
admet-579	60	4	pbpk	pbpk	NOUN
admet-579	60	5	modeling	modeling	NOUN
admet-579	60	6	requires	require	VERB
admet-579	60	7	input	input	NOUN
admet-579	60	8	of	of	ADP
admet-579	60	9	a	a	DET
admet-579	60	10	standard	standard	ADJ
admet-579	60	11	set	set	NOUN
admet-579	60	12	of	of	ADP
admet-579	60	13	the	the	DET
admet-579	60	14	28	28	NUM
admet-579	60	15	tissue	tissue	NOUN
admet-579	60	16	volume	volume	NOUN
admet-579	60	17	(	(	PUNCT
admet-579	60	18	vti	vti	PROPN
admet-579	60	19	)	)	PUNCT
admet-579	60	20	and	and	CCONJ
admet-579	60	21	blood	blood	NOUN
admet-579	60	22	flow	flow	NOUN
admet-579	60	23	(	(	PUNCT
admet-579	60	24	fi	fi	NOUN
admet-579	60	25	)	)	PUNCT
admet-579	60	26	parameters	parameter	NOUN
admet-579	60	27	.	.	PUNCT
admet-579	61	1	in	in	ADP
admet-579	61	2	pkquest	pkqu	ADJ
admet-579	61	3	,	,	PUNCT
admet-579	61	4	a	a	DET
admet-579	61	5	“	"	PUNCT
admet-579	61	6	standard	standard	ADJ
admet-579	61	7	human	human	NOUN
admet-579	61	8	”	"	PUNCT
admet-579	61	9	set	set	NOUN
admet-579	61	10	of	of	ADP
admet-579	61	11	these	these	DET
admet-579	61	12	parameters	parameter	NOUN
admet-579	61	13	has	have	AUX
admet-579	61	14	been	be	AUX
admet-579	61	15	refined	refine	VERB
admet-579	61	16	by	by	ADP
admet-579	61	17	application	application	NOUN
admet-579	61	18	of	of	ADP
admet-579	61	19	pkquest	pkquest	NOUN
admet-579	61	20	to	to	ADP
admet-579	61	21	hundreds	hundred	NOUN
admet-579	61	22	of	of	ADP
admet-579	61	23	solutes	solute	NOUN
admet-579	61	24	with	with	ADP
admet-579	61	25	varying	vary	VERB
admet-579	61	26	properties	property	NOUN
admet-579	61	27	.	.	PUNCT
admet-579	62	1	for	for	ADP
admet-579	62	2	example	example	NOUN
admet-579	62	3	,	,	PUNCT
admet-579	62	4	the	the	DET
admet-579	62	5	muscle	muscle	NOUN
admet-579	62	6	blood	blood	NOUN
admet-579	62	7	flow	flow	NOUN
admet-579	62	8	was	be	AUX
admet-579	62	9	determined	determine	VERB
admet-579	62	10	from	from	ADP
admet-579	62	11	the	the	DET
admet-579	62	12	pk	pk	PROPN
admet-579	62	13	of	of	ADP
admet-579	62	14	d2o	d2o	PROPN
admet-579	62	15	and	and	CCONJ
admet-579	62	16	the	the	DET
admet-579	62	17	adipose	adipose	ADJ
admet-579	62	18	blood	blood	NOUN
admet-579	62	19	flows	flow	VERB
admet-579	62	20	from	from	ADP
admet-579	62	21	the	the	DET
admet-579	62	22	pk	pk	NOUN
admet-579	62	23	of	of	ADP
admet-579	62	24	the	the	DET
admet-579	62	25	volatile	volatile	ADJ
admet-579	62	26	anesthetics	anesthetic	NOUN
admet-579	62	27	(	(	PUNCT
admet-579	62	28	see	see	VERB
admet-579	62	29	below	below	ADV
admet-579	62	30	)	)	PUNCT
admet-579	62	31	.	.	PUNCT
admet-579	63	1	these	these	DET
admet-579	63	2	“	"	PUNCT
admet-579	63	3	standard	standard	ADJ
admet-579	63	4	human	human	ADJ
admet-579	63	5	”	"	PUNCT
admet-579	63	6	values	value	NOUN
admet-579	63	7	are	be	AUX
admet-579	63	8	listed	list	VERB
admet-579	63	9	in	in	ADP
admet-579	63	10	table	table	NOUN
admet-579	63	11	1	1	NUM
admet-579	63	12	(	(	PUNCT
admet-579	63	13	in	in	ADP
admet-579	63	14	pkquest	pkqu	ADJ
admet-579	63	15	,	,	PUNCT
admet-579	63	16	the	the	DET
admet-579	63	17	default	default	NOUN
admet-579	63	18	units	unit	NOUN
admet-579	63	19	are	be	AUX
admet-579	63	20	minutes	minute	NOUN
admet-579	63	21	,	,	PUNCT
admet-579	63	22	liters	liter	NOUN
admet-579	63	23	and	and	CCONJ
admet-579	63	24	kilograms	kilogram	NOUN
admet-579	63	25	)	)	PUNCT
admet-579	63	26	.	.	PUNCT
admet-579	64	1	since	since	SCONJ
admet-579	64	2	these	these	PRON
admet-579	64	3	are	be	AUX
admet-579	64	4	the	the	DET
admet-579	64	5	default	default	NOUN
admet-579	64	6	background	background	NOUN
admet-579	64	7	values	value	NOUN
admet-579	64	8	,	,	PUNCT
admet-579	64	9	the	the	DET
admet-579	64	10	user	user	NOUN
admet-579	64	11	does	do	AUX
admet-579	64	12	not	not	PART
admet-579	64	13	need	need	VERB
admet-579	64	14	to	to	PART
admet-579	64	15	be	be	AUX
admet-579	64	16	concerned	concern	VERB
admet-579	64	17	with	with	ADP
admet-579	64	18	supplying	supply	VERB
admet-579	64	19	them	they	PRON
admet-579	64	20	.	.	PUNCT
admet-579	65	1	of	of	ADP
admet-579	65	2	course	course	NOUN
admet-579	65	3	,	,	PUNCT
admet-579	65	4	pkquest	pkquest	PROPN
admet-579	65	5	allows	allow	VERB
admet-579	65	6	these	these	DET
admet-579	65	7	values	value	NOUN
admet-579	65	8	to	to	PART
admet-579	65	9	be	be	AUX
admet-579	65	10	varied	varied	ADJ
admet-579	65	11	in	in	ADP
admet-579	65	12	the	the	DET
admet-579	65	13	more	more	ADV
admet-579	65	14	general	general	ADJ
admet-579	65	15	case	case	NOUN
admet-579	65	16	.	.	PUNCT
admet-579	66	1	one	one	NUM
admet-579	66	2	of	of	ADP
admet-579	66	3	the	the	DET
admet-579	66	4	novel	novel	ADJ
admet-579	66	5	features	feature	NOUN
admet-579	66	6	of	of	ADP
admet-579	66	7	pkquest	pkquest	NOUN
admet-579	66	8	is	be	AUX
admet-579	66	9	that	that	SCONJ
admet-579	66	10	it	it	PRON
admet-579	66	11	is	be	AUX
admet-579	66	12	designed	design	VERB
admet-579	66	13	so	so	SCONJ
admet-579	66	14	that	that	SCONJ
admet-579	66	15	the	the	DET
admet-579	66	16	pbpk	pbpk	NOUN
admet-579	66	17	modeling	modeling	NOUN
admet-579	66	18	of	of	ADP
admet-579	66	19	hls	hls	PROPN
admet-579	66	20	and	and	CCONJ
admet-579	66	21	ecs	ecs	NOUN
admet-579	66	22	solutes	solute	NOUN
admet-579	66	23	can	can	AUX
admet-579	66	24	be	be	AUX
admet-579	66	25	run	run	VERB
admet-579	66	26	by	by	ADP
admet-579	66	27	entering	enter	VERB
admet-579	66	28	just	just	ADV
admet-579	66	29	the	the	DET
admet-579	66	30	minimum	minimum	ADJ
admet-579	66	31	set	set	NOUN
admet-579	66	32	of	of	ADP
admet-579	66	33	adjustable	adjustable	ADJ
admet-579	66	34	parameters	parameter	NOUN
admet-579	66	35	(	(	PUNCT
admet-579	66	36	body	body	NOUN
admet-579	66	37	fat	fat	ADJ
admet-579	66	38	fraction	fraction	NOUN
admet-579	66	39	,	,	PUNCT
admet-579	66	40	pl	pl	PROPN
admet-579	66	41	/	/	SYM
admet-579	66	42	w	w	PROPN
admet-579	66	43	,	,	PUNCT
admet-579	66	44	albumin	albumin	ADJ
admet-579	66	45	binding	binding	NOUN
admet-579	66	46	,	,	PUNCT
admet-579	66	47	etc	etc	X
admet-579	66	48	.	.	X
admet-579	66	49	)	)	PUNCT
admet-579	66	50	with	with	ADP
admet-579	66	51	all	all	DET
admet-579	66	52	the	the	DET
admet-579	66	53	other	other	ADJ
admet-579	66	54	required	require	VERB
admet-579	66	55	human	human	ADJ
admet-579	66	56	parameters	parameter	NOUN
admet-579	66	57	as	as	ADP
admet-579	66	58	standard	standard	ADJ
admet-579	66	59	defaults	default	NOUN
admet-579	66	60	.	.	PUNCT
admet-579	67	1	in	in	ADP
admet-579	67	2	addition	addition	NOUN
admet-579	67	3	to	to	ADP
admet-579	67	4	potentially	potentially	ADV
admet-579	67	5	predicting	predict	VERB
admet-579	67	6	the	the	DET
admet-579	67	7	pk	pk	NOUN
admet-579	67	8	of	of	ADP
admet-579	67	9	unknown	unknown	ADJ
admet-579	67	10	solutes	solute	NOUN
admet-579	67	11	,	,	PUNCT
admet-579	67	12	this	this	DET
admet-579	67	13	pbpk	pbpk	ADJ
admet-579	67	14	application	application	NOUN
admet-579	67	15	is	be	AUX
admet-579	67	16	of	of	ADP
admet-579	67	17	heuristic	heuristic	ADJ
admet-579	67	18	value	value	NOUN
admet-579	67	19	in	in	ADV
admet-579	67	20	,	,	PUNCT
admet-579	67	21	for	for	ADP
admet-579	67	22	example	example	NOUN
admet-579	67	23	,	,	PUNCT
admet-579	67	24	teaching	teach	VERB
admet-579	67	25	nurse	nurse	NOUN
admet-579	67	26	anesthetists	anesthetist	NOUN
admet-579	67	27	how	how	SCONJ
admet-579	67	28	the	the	DET
admet-579	67	29	pk	pk	NOUN
admet-579	67	30	of	of	ADP
admet-579	67	31	volatile	volatile	ADJ
admet-579	67	32	anesthetics	anesthetic	NOUN
admet-579	67	33	depends	depend	VERB
admet-579	67	34	on	on	ADP
admet-579	67	35	,	,	PUNCT
admet-579	67	36	e.g.	e.g.	ADV
admet-579	67	37	respiratory	respiratory	ADJ
admet-579	67	38	rate	rate	NOUN
admet-579	67	39	.	.	PUNCT
admet-579	68	1	the	the	DET
admet-579	68	2	following	follow	VERB
admet-579	68	3	two	two	NUM
admet-579	68	4	sections	section	NOUN
admet-579	68	5	will	will	AUX
admet-579	68	6	review	review	VERB
admet-579	68	7	the	the	DET
admet-579	68	8	pk	pk	NOUN
admet-579	68	9	of	of	ADP
admet-579	68	10	these	these	DET
admet-579	68	11	two	two	NUM
admet-579	68	12	solute	solute	ADJ
admet-579	68	13	classes	class	NOUN
admet-579	68	14	along	along	ADV
admet-579	68	15	with	with	ADP
admet-579	68	16	clinical	clinical	ADJ
admet-579	68	17	examples	example	NOUN
admet-579	68	18	of	of	ADP
admet-579	68	19	the	the	DET
admet-579	68	20	application	application	NOUN
admet-579	68	21	of	of	ADP
admet-579	68	22	pkquest	pkquest	NOUN
admet-579	68	23	to	to	ADP
admet-579	68	24	specific	specific	ADJ
admet-579	68	25	solutes	solute	NOUN
admet-579	68	26	.	.	PUNCT
admet-579	69	1	highly	highly	ADV
admet-579	69	2	lipid	lipid	ADJ
admet-579	69	3	soluble	soluble	ADJ
admet-579	69	4	solutes	solute	NOUN
admet-579	69	5	(	(	PUNCT
admet-579	69	6	hls	hls	NOUN
admet-579	69	7	)	)	PUNCT
admet-579	69	8	for	for	ADP
admet-579	69	9	an	an	DET
admet-579	69	10	ideal	ideal	ADJ
admet-579	69	11	hls	hls	PROPN
admet-579	69	12	solute	solute	NOUN
admet-579	69	13	,	,	PUNCT
admet-579	69	14	the	the	DET
admet-579	69	15	tissue	tissue	NOUN
admet-579	69	16	/	/	SYM
admet-579	69	17	blood	blood	NOUN
admet-579	69	18	partition	partition	NOUN
admet-579	69	19	ki	ki	PROPN
admet-579	69	20	is	be	AUX
admet-579	69	21	determined	determine	VERB
admet-579	69	22	entirely	entirely	ADV
admet-579	69	23	by	by	ADP
admet-579	69	24	the	the	DET
admet-579	69	25	lipid	lipid	NOUN
admet-579	69	26	fraction	fraction	NOUN
admet-579	69	27	of	of	ADP
admet-579	69	28	the	the	DET
admet-579	69	29	tissue	tissue	NOUN
admet-579	69	30	(	(	PUNCT
admet-579	69	31	fl	fl	NOUN
admet-579	69	32	i	i	NOUN
admet-579	69	33	)	)	PUNCT
admet-579	69	34	and	and	CCONJ
admet-579	69	35	blood	blood	NOUN
admet-579	69	36	(	(	PUNCT
admet-579	69	37	fl	fl	NOUN
admet-579	69	38	b	b	NOUN
admet-579	69	39	)	)	PUNCT
admet-579	69	40	and	and	CCONJ
admet-579	69	41	the	the	DET
admet-579	69	42	lipid	lipid	NOUN
admet-579	69	43	/	/	SYM
admet-579	69	44	water	water	NOUN
admet-579	69	45	partition	partition	NOUN
admet-579	69	46	fraction	fraction	NOUN
admet-579	69	47	(	(	PUNCT
admet-579	69	48	pl	pl	NOUN
admet-579	69	49	/	/	SYM
admet-579	69	50	w	w	NOUN
admet-579	69	51	)	)	PUNCT
admet-579	70	1	[	[	X
admet-579	70	2	1	1	NUM
admet-579	70	3	]	]	PUNCT
admet-579	70	4	:	:	PUNCT
admet-579	70	5	admet	admet	PROPN
admet-579	70	6	&	&	CCONJ
admet-579	70	7	dmpk	dmpk	PROPN
admet-579	70	8	7(1	7(1	PROPN
admet-579	70	9	)	)	PUNCT
admet-579	70	10	(	(	PUNCT
admet-579	70	11	2019	2019	NUM
admet-579	70	12	)	)	PUNCT
admet-579	70	13	60	60	NUM
admet-579	70	14	-	-	SYM
admet-579	70	15	75	75	NUM
admet-579	70	16	lipid	lipid	NOUN
admet-579	70	17	soluble	soluble	ADJ
admet-579	70	18	and	and	CCONJ
admet-579	70	19	extracellular	extracellular	ADJ
admet-579	70	20	solutes	solute	NOUN
admet-579	70	21	doi	doi	NOUN
admet-579	70	22	:	:	PUNCT
admet-579	70	23	10.5599	10.5599	NUM
admet-579	70	24	/	/	SYM
admet-579	70	25	admet.579	admet.579	NOUN
admet-579	70	26	63	63	NUM
admet-579	70	27	1	1	NUM
admet-579	70	28	1	1	NUM
admet-579	70	29	i	i	PRON
admet-579	70	30	i	i	VERB
admet-579	70	31	l	l	PROPN
admet-579	70	32	l	l	X
admet-579	70	33	/	/	SYM
admet-579	70	34	w	w	PROPN
admet-579	70	35	li	li	PROPN
admet-579	71	1	b	b	PROPN
admet-579	71	2	b	b	PROPN
admet-579	71	3	l	l	PROPN
admet-579	71	4	l	l	NOUN
admet-579	71	5	/	/	SYM
admet-579	71	6	w	w	PROPN
admet-579	71	7	l	l	NOUN
admet-579	71	8	(	(	PUNCT
admet-579	71	9	)	)	PUNCT
admet-579	71	10	(	(	PUNCT
admet-579	71	11	)	)	PUNCT
admet-579	71	12	f	f	PROPN
admet-579	72	1	p	p	X
admet-579	72	2	f	f	PROPN
admet-579	73	1	k	k	PROPN
admet-579	73	2	f	f	PROPN
admet-579	74	1	p	p	X
admet-579	74	2	f	f	PROPN
admet-579	74	3			PROPN
admet-579	74	4			PROPN
admet-579	74	5			PROPN
admet-579	74	6			PROPN
admet-579	74	7			X
admet-579	74	8	(	(	PUNCT
admet-579	74	9	3	3	X
admet-579	74	10	)	)	PUNCT
admet-579	74	11	equation	equation	NOUN
admet-579	74	12	(	(	PUNCT
admet-579	74	13	3	3	X
admet-579	74	14	)	)	PUNCT
admet-579	74	15	assumes	assume	VERB
admet-579	74	16	that	that	SCONJ
admet-579	74	17	the	the	DET
admet-579	74	18	blood	blood	NOUN
admet-579	74	19	hls	hls	NOUN
admet-579	74	20	binding	binding	NOUN
admet-579	74	21	is	be	AUX
admet-579	74	22	due	due	ADJ
admet-579	74	23	entirely	entirely	ADV
admet-579	74	24	to	to	ADP
admet-579	74	25	the	the	DET
admet-579	74	26	blood	blood	NOUN
admet-579	74	27	lipid	lipid	NOUN
admet-579	74	28	fraction	fraction	NOUN
admet-579	74	29	(	(	PUNCT
admet-579	74	30	fl	fl	PROPN
admet-579	74	31	b	b	PROPN
admet-579	74	32	)	)	PUNCT
admet-579	74	33	.	.	PUNCT
admet-579	75	1	in	in	ADP
admet-579	75	2	humans	human	NOUN
admet-579	75	3	,	,	PUNCT
admet-579	75	4	the	the	DET
admet-579	75	5	directly	directly	ADV
admet-579	75	6	measured	measure	VERB
admet-579	75	7	fl	fl	PROPN
admet-579	75	8	b	b	PROPN
admet-579	75	9	is	be	AUX
admet-579	75	10	about	about	ADV
admet-579	75	11	0.005	0.005	NUM
admet-579	75	12	[	[	X
admet-579	75	13	12	12	NUM
admet-579	75	14	]	]	PUNCT
admet-579	75	15	.	.	PUNCT
admet-579	76	1	however	however	ADV
admet-579	76	2	,	,	PUNCT
admet-579	76	3	using	use	VERB
admet-579	76	4	this	this	DET
admet-579	76	5	value	value	NOUN
admet-579	76	6	often	often	ADV
admet-579	76	7	underestimates	underestimate	VERB
admet-579	76	8	the	the	DET
admet-579	76	9	blood	blood	NOUN
admet-579	76	10	hls	hls	NOUN
admet-579	76	11	binding	bind	VERB
admet-579	76	12	because	because	SCONJ
admet-579	76	13	there	there	PRON
admet-579	76	14	is	be	VERB
admet-579	76	15	additional	additional	ADJ
admet-579	76	16	plasma	plasma	NOUN
admet-579	76	17	hls	hls	NOUN
admet-579	76	18	binding	bind	VERB
admet-579	76	19	,	,	PUNCT
admet-579	76	20	primarily	primarily	ADV
admet-579	76	21	by	by	ADP
admet-579	76	22	albumin	albumin	NOUN
admet-579	76	23	.	.	PUNCT
admet-579	77	1	the	the	DET
admet-579	77	2	procedure	procedure	NOUN
admet-579	77	3	used	use	VERB
admet-579	77	4	in	in	ADP
admet-579	77	5	pkquest	pkquest	NOUN
admet-579	77	6	is	be	AUX
admet-579	77	7	to	to	PART
admet-579	77	8	input	input	VERB
admet-579	77	9	the	the	DET
admet-579	77	10	in	in	ADV
admet-579	77	11	vitro	vitro	X
admet-579	77	12	measurement	measurement	NOUN
admet-579	77	13	of	of	ADP
admet-579	77	14	the	the	DET
admet-579	77	15	“	"	PUNCT
admet-579	77	16	free	free	ADJ
admet-579	77	17	plasma	plasma	NOUN
admet-579	77	18	fraction	fraction	NOUN
admet-579	77	19	”	"	PUNCT
admet-579	77	20	if	if	SCONJ
admet-579	77	21	it	it	PRON
admet-579	77	22	is	be	AUX
admet-579	77	23	known	know	VERB
admet-579	77	24	and	and	CCONJ
admet-579	77	25	then	then	ADV
admet-579	77	26	use	use	VERB
admet-579	77	27	this	this	DET
admet-579	77	28	value	value	NOUN
admet-579	77	29	to	to	PART
admet-579	77	30	estimate	estimate	VERB
admet-579	77	31	the	the	DET
admet-579	77	32	apparent	apparent	ADJ
admet-579	77	33	fl	fl	X
admet-579	77	34	b.	b.	PROPN
admet-579	77	35	if	if	SCONJ
admet-579	77	36	it	it	PRON
admet-579	77	37	is	be	AUX
admet-579	77	38	not	not	PART
admet-579	77	39	known	know	VERB
admet-579	77	40	,	,	PUNCT
admet-579	77	41	the	the	DET
admet-579	77	42	default	default	NOUN
admet-579	77	43	fl	fl	PROPN
admet-579	77	44	b	b	PROPN
admet-579	77	45	of	of	ADP
admet-579	77	46	0.015	0.015	NUM
admet-579	77	47	(	(	PUNCT
admet-579	77	48	table	table	NOUN
admet-579	77	49	1	1	NUM
admet-579	77	50	)	)	PUNCT
admet-579	77	51	provides	provide	VERB
admet-579	77	52	a	a	DET
admet-579	77	53	rough	rough	ADJ
admet-579	77	54	starting	starting	NOUN
admet-579	77	55	estimate	estimate	NOUN
admet-579	77	56	and	and	CCONJ
admet-579	77	57	it	it	PRON
admet-579	77	58	is	be	AUX
admet-579	77	59	then	then	ADV
admet-579	77	60	treated	treat	VERB
admet-579	77	61	as	as	ADP
admet-579	77	62	an	an	DET
admet-579	77	63	adjustable	adjustable	ADJ
admet-579	77	64	parameter	parameter	NOUN
admet-579	77	65	.	.	PUNCT
admet-579	78	1	table	table	NOUN
admet-579	78	2	1	1	NUM
admet-579	78	3	.	.	PUNCT
admet-579	78	4	organ	organ	VERB
admet-579	78	5	pbpk	pbpk	NOUN
admet-579	78	6	parameters	parameter	NOUN
admet-579	78	7	for	for	ADP
admet-579	78	8	the	the	DET
admet-579	78	9	standard	standard	ADJ
admet-579	78	10	20	20	NUM
admet-579	78	11	%	%	NOUN
admet-579	78	12	fat	fat	NOUN
admet-579	78	13	,	,	PUNCT
admet-579	78	14	70	70	NUM
admet-579	78	15	kg	kg	NOUN
admet-579	78	16	human	human	NOUN
admet-579	78	17	.	.	PUNCT
admet-579	79	1	the	the	DET
admet-579	79	2	organ	organ	NOUN
admet-579	79	3	“	"	PUNCT
admet-579	79	4	portal	portal	ADJ
admet-579	79	5	”	"	PUNCT
admet-579	79	6	refers	refer	VERB
admet-579	79	7	to	to	ADP
admet-579	79	8	all	all	DET
admet-579	79	9	the	the	DET
admet-579	79	10	organs	organ	NOUN
admet-579	79	11	drained	drain	VERB
admet-579	79	12	by	by	ADP
admet-579	79	13	the	the	DET
admet-579	79	14	portal	portal	ADJ
admet-579	79	15	vein	vein	NOUN
admet-579	79	16	(	(	PUNCT
admet-579	79	17	eg	eg	NOUN
admet-579	79	18	,	,	PUNCT
admet-579	79	19	gi	gi	NOUN
admet-579	79	20	tract	tract	NOUN
admet-579	79	21	,	,	PUNCT
admet-579	79	22	spleen	spleen	NOUN
admet-579	79	23	,	,	PUNCT
admet-579	79	24	pancreas	pancrea	NOUN
admet-579	79	25	)	)	PUNCT
admet-579	79	26	.	.	PUNCT
admet-579	80	1	the	the	DET
admet-579	80	2	organs	organ	NOUN
admet-579	80	3	“	"	PUNCT
admet-579	80	4	tendon	tendon	PROPN
admet-579	80	5	”	"	PUNCT
admet-579	80	6	and	and	CCONJ
admet-579	80	7	“	"	PUNCT
admet-579	80	8	other	other	ADJ
admet-579	80	9	”	"	PUNCT
admet-579	80	10	represent	represent	VERB
admet-579	80	11	poorly	poorly	ADV
admet-579	80	12	characterized	characterize	VERB
admet-579	80	13	,	,	PUNCT
admet-579	80	14	low	low	ADJ
admet-579	80	15	flow	flow	NOUN
admet-579	80	16	connective	connective	ADJ
admet-579	80	17	tissues	tissue	NOUN
admet-579	80	18	.	.	PUNCT
admet-579	81	1	the	the	DET
admet-579	81	2	adipose	adipose	NOUN
admet-579	81	3	and	and	CCONJ
admet-579	81	4	adipose	adipose	X
admet-579	81	5	2	2	NUM
admet-579	81	6	organ	organ	NOUN
admet-579	81	7	weights	weight	NOUN
admet-579	81	8	(	(	PUNCT
admet-579	81	9	assumed	assume	VERB
admet-579	81	10	equal	equal	ADJ
admet-579	81	11	)	)	PUNCT
admet-579	81	12	are	be	AUX
admet-579	81	13	adjusted	adjust	VERB
admet-579	81	14	for	for	ADP
admet-579	81	15	the	the	DET
admet-579	81	16	individual	individual	NOUN
admet-579	81	17	’s	’s	PART
admet-579	81	18	body	body	NOUN
admet-579	81	19	fat	fat	ADJ
admet-579	81	20	fraction	fraction	NOUN
admet-579	81	21	.	.	PUNCT
admet-579	82	1	the	the	DET
admet-579	82	2	ecf	ecf	PROPN
admet-579	82	3	fraction	fraction	NOUN
admet-579	82	4	is	be	AUX
admet-579	82	5	the	the	DET
admet-579	82	6	fraction	fraction	NOUN
admet-579	82	7	of	of	ADP
admet-579	82	8	the	the	DET
admet-579	82	9	non	non	ADJ
admet-579	82	10	-	-	ADJ
admet-579	82	11	lipid	lipid	ADJ
admet-579	82	12	organ	organ	NOUN
admet-579	82	13	weight	weight	NOUN
admet-579	82	14	that	that	PRON
admet-579	82	15	is	be	AUX
admet-579	82	16	extracellular	extracellular	ADJ
admet-579	82	17	.	.	PUNCT
admet-579	83	1	kalb	kalb	PROPN
admet-579	83	2	is	be	AUX
admet-579	83	3	the	the	DET
admet-579	83	4	ratio	ratio	NOUN
admet-579	83	5	of	of	ADP
admet-579	83	6	the	the	DET
admet-579	83	7	albumin	albumin	ADJ
admet-579	83	8	concentration	concentration	NOUN
admet-579	83	9	in	in	ADP
admet-579	83	10	the	the	DET
admet-579	83	11	edta	edta	NOUN
admet-579	83	12	interstitial	interstitial	ADJ
admet-579	83	13	space	space	NOUN
admet-579	83	14	relative	relative	ADJ
admet-579	83	15	to	to	ADP
admet-579	83	16	the	the	DET
admet-579	83	17	plasma	plasma	NOUN
admet-579	83	18	albumin	albumin	NOUN
admet-579	83	19	.	.	PUNCT
admet-579	84	1	organ	organ	NOUN
admet-579	84	2	weight	weight	NOUN
admet-579	84	3	(	(	PUNCT
admet-579	84	4	kg	kg	NOUN
admet-579	84	5	)	)	PUNCT
admet-579	84	6	perfusion	perfusion	NOUN
admet-579	84	7	(	(	PUNCT
admet-579	84	8	l	l	NOUN
admet-579	84	9	/	/	SYM
admet-579	84	10	min	min	NOUN
admet-579	84	11	/	/	SYM
admet-579	84	12	kg	kg	NOUN
admet-579	84	13	)	)	PUNCT
admet-579	84	14	lipid	lipid	NOUN
admet-579	84	15	fraction	fraction	NOUN
admet-579	84	16	ecf	ecf	PROPN
admet-579	84	17	fraction	fraction	PROPN
admet-579	84	18	kalb	kalb	PROPN
admet-579	84	19	vein	vein	VERB
admet-579	84	20	4.29	4.29	NUM
admet-579	84	21	1.0	1.0	NUM
admet-579	84	22	0.015	0.015	NUM
admet-579	84	23	0.595	0.595	NUM
admet-579	84	24	na	na	ADP
admet-579	84	25	artery	artery	NOUN
admet-579	84	26	1.21	1.21	NUM
admet-579	84	27	0.0	0.0	NUM
admet-579	84	28	0.015	0.015	NUM
admet-579	84	29	0.595	0.595	NUM
admet-579	84	30	na	na	PART
admet-579	84	31	liver	liver	VERB
admet-579	84	32	1.8	1.8	NUM
admet-579	84	33	0.25	0.25	NUM
admet-579	84	34	0.02	0.02	NUM
admet-579	84	35	0.23	0.23	NUM
admet-579	84	36	0.5	0.5	NUM
admet-579	84	37	portal	portal	ADJ
admet-579	84	38	1.5	1.5	NUM
admet-579	84	39	0.75	0.75	NUM
admet-579	84	40	0.016	0.016	NUM
admet-579	84	41	0.3	0.3	NUM
admet-579	84	42	0.35	0.35	NUM
admet-579	84	43	kidney	kidney	NOUN
admet-579	84	44	0.31	0.31	NUM
admet-579	84	45	4.0	4.0	NUM
admet-579	84	46	0.0136	0.0136	NUM
admet-579	84	47	0.165	0.165	NUM
admet-579	84	48	0.35	0.35	NUM
admet-579	84	49	brain	brain	NOUN
admet-579	84	50	1.4	1.4	NUM
admet-579	84	51	0.56	0.56	NUM
admet-579	84	52	0.0176	0.0176	NUM
admet-579	84	53	0	0	NUM
admet-579	84	54	0.1	0.1	NUM
admet-579	84	55	heart	heart	NOUN
admet-579	84	56	0.33	0.33	NUM
admet-579	84	57	0.8	0.8	NUM
admet-579	84	58	0.0136	0.0136	NUM
admet-579	84	59	0.264	0.264	NUM
admet-579	84	60	0.5	0.5	NUM
admet-579	84	61	muscle	muscle	NOUN
admet-579	84	62	26.0	26.0	NUM
admet-579	84	63	0.0225	0.0225	NUM
admet-579	84	64	0.0136	0.0136	NUM
admet-579	84	65	0.15	0.15	NUM
admet-579	84	66	0.5	0.5	NUM
admet-579	84	67	skin	skin	NOUN
admet-579	84	68	2.6	2.6	NUM
admet-579	84	69	0.1	0.1	NUM
admet-579	84	70	0.0136	0.0136	NUM
admet-579	84	71	0.6	0.6	NUM
admet-579	84	72	0.25	0.25	NUM
admet-579	84	73	lung	lung	NOUN
admet-579	84	74	0.536	0.536	NUM
admet-579	84	75	-1.0	-1.0	PROPN
admet-579	84	76	0.0136	0.0136	NUM
admet-579	84	77	0.2	0.2	NUM
admet-579	84	78	0.35	0.35	NUM
admet-579	84	79	tendon	tendon	NOUN
admet-579	84	80	3.0	3.0	NUM
admet-579	84	81	0.01	0.01	NUM
admet-579	84	82	0.0136	0.0136	NUM
admet-579	84	83	1	1	NUM
admet-579	84	84	0.25	0.25	NUM
admet-579	84	85	other	other	ADJ
admet-579	84	86	5.522	5.522	NUM
admet-579	84	87	0.02	0.02	NUM
admet-579	84	88	0.0136	0.0136	NUM
admet-579	84	89	0.2	0.2	NUM
admet-579	84	90	0.25	0.25	NUM
admet-579	84	91	adipose	adipose	ADP
admet-579	84	92	8.758	8.758	NUM
admet-579	84	93	0.074	0.074	NUM
admet-579	84	94	0.8	0.8	NUM
admet-579	84	95	1	1	NUM
admet-579	84	96	0.35	0.35	NUM
admet-579	84	97	adipose	adipose	ADP
admet-579	84	98	2	2	NUM
admet-579	84	99	8.758	8.758	NUM
admet-579	84	100	0.01408	0.01408	NUM
admet-579	84	101	0.8	0.8	NUM
admet-579	84	102	1	1	NUM
admet-579	84	103	0.35	0.35	NUM
admet-579	84	104	bone	bone	NOUN
admet-579	84	105	4.0	4.0	NUM
admet-579	84	106	0.0	0.0	NUM
admet-579	84	107	0	0	NUM
admet-579	84	108	0	0	NUM
admet-579	84	109	0	0	NUM
admet-579	84	110	the	the	DET
admet-579	84	111	volatile	volatile	ADJ
admet-579	84	112	anesthetics	anesthetic	NOUN
admet-579	84	113	represent	represent	VERB
admet-579	84	114	the	the	DET
admet-579	84	115	ideal	ideal	ADJ
admet-579	84	116	hls	hls	NOUN
admet-579	84	117	because	because	SCONJ
admet-579	84	118	they	they	PRON
admet-579	84	119	are	be	AUX
admet-579	84	120	relatively	relatively	ADV
admet-579	84	121	inert	inert	ADJ
admet-579	84	122	,	,	PUNCT
admet-579	84	123	have	have	VERB
admet-579	84	124	negligible	negligible	ADJ
admet-579	84	125	specific	specific	ADJ
admet-579	84	126	tissue	tissue	NOUN
admet-579	84	127	binding	bind	VERB
admet-579	84	128	and	and	CCONJ
admet-579	84	129	,	,	PUNCT
admet-579	84	130	in	in	ADP
admet-579	84	131	most	most	ADJ
admet-579	84	132	cases	case	NOUN
admet-579	84	133	,	,	PUNCT
admet-579	84	134	are	be	AUX
admet-579	84	135	not	not	PART
admet-579	84	136	metabolized	metabolize	VERB
admet-579	84	137	with	with	ADP
admet-579	84	138	their	their	PRON
admet-579	84	139	clearance	clearance	NOUN
admet-579	84	140	determined	determine	VERB
admet-579	84	141	solely	solely	ADV
admet-579	84	142	by	by	ADP
admet-579	84	143	the	the	DET
admet-579	84	144	respiration	respiration	NOUN
admet-579	84	145	rate	rate	NOUN
admet-579	84	146	and	and	CCONJ
admet-579	84	147	blood	blood	NOUN
admet-579	84	148	/	/	SYM
admet-579	84	149	gas	gas	NOUN
admet-579	84	150	partition	partition	NOUN
admet-579	84	151	.	.	PUNCT
admet-579	85	1	thus	thus	ADV
admet-579	85	2	,	,	PUNCT
admet-579	85	3	their	their	PRON
admet-579	85	4	pk	pk	NOUN
admet-579	85	5	can	can	AUX
admet-579	85	6	be	be	AUX
admet-579	85	7	predicted	predict	VERB
admet-579	85	8	using	use	VERB
admet-579	85	9	the	the	DET
admet-579	85	10	hls	hls	PROPN
admet-579	85	11	pbpk	pbpk	NOUN
admet-579	85	12	model	model	NOUN
admet-579	85	13	along	along	ADP
admet-579	85	14	with	with	ADP
admet-579	85	15	in	in	ADP
admet-579	85	16	vitro	vitro	X
admet-579	85	17	measurements	measurement	NOUN
admet-579	85	18	of	of	ADP
admet-579	85	19	oil	oil	NOUN
admet-579	85	20	/	/	SYM
admet-579	85	21	water	water	NOUN
admet-579	85	22	,	,	PUNCT
admet-579	85	23	blood	blood	NOUN
admet-579	85	24	/	/	SYM
admet-579	85	25	water	water	NOUN
admet-579	85	26	and	and	CCONJ
admet-579	85	27	air	air	NOUN
admet-579	85	28	/	/	SYM
admet-579	85	29	water	water	NOUN
admet-579	85	30	partition	partition	NOUN
admet-579	85	31	coefficients	coefficient	NOUN
admet-579	85	32	with	with	ADP
admet-579	85	33	no	no	DET
admet-579	85	34	adjustable	adjustable	ADJ
admet-579	85	35	individual	individual	ADJ
admet-579	85	36	subject	subject	NOUN
admet-579	85	37	parameters	parameter	NOUN
admet-579	85	38	.	.	PUNCT
admet-579	86	1	for	for	ADP
admet-579	86	2	the	the	DET
admet-579	86	3	volatile	volatile	ADJ
admet-579	86	4	anesthetics	anesthetic	NOUN
admet-579	86	5	there	there	PRON
admet-579	86	6	are	be	VERB
admet-579	86	7	detailed	detailed	ADJ
admet-579	86	8	measurements	measurement	NOUN
admet-579	86	9	of	of	ADP
admet-579	86	10	the	the	DET
admet-579	86	11	oil	oil	NOUN
admet-579	86	12	/	/	SYM
admet-579	86	13	water	water	NOUN
admet-579	86	14	,	,	PUNCT
admet-579	86	15	air	air	NOUN
admet-579	86	16	/	/	SYM
admet-579	86	17	water	water	NOUN
admet-579	86	18	,	,	PUNCT
admet-579	86	19	blood	blood	NOUN
admet-579	86	20	/	/	SYM
admet-579	86	21	gas	gas	NOUN
admet-579	86	22	and	and	CCONJ
admet-579	86	23	various	various	ADJ
admet-579	86	24	tissue	tissue	NOUN
admet-579	86	25	partition	partition	NOUN
admet-579	86	26	coefficients	coefficient	NOUN
admet-579	86	27	(	(	PUNCT
admet-579	86	28	ki	ki	PROPN
admet-579	86	29	)	)	PUNCT
admet-579	86	30	,	,	PUNCT
admet-579	86	31	all	all	PRON
admet-579	86	32	of	of	ADP
admet-579	86	33	which	which	PRON
admet-579	86	34	are	be	AUX
admet-579	86	35	qualitatively	qualitatively	ADV
admet-579	86	36	consistent	consistent	ADJ
admet-579	86	37	with	with	ADP
admet-579	86	38	eq	eq	NOUN
admet-579	86	39	.	.	PUNCT
admet-579	87	1	(	(	PUNCT
admet-579	87	2	3	3	NUM
admet-579	87	3	)	)	PUNCT
admet-579	87	4	.	.	PUNCT
admet-579	88	1	the	the	DET
admet-579	88	2	pbpk	pbpk	PROPN
admet-579	88	3	parameter	parameter	NOUN
admet-579	88	4	that	that	PRON
admet-579	88	5	dominates	dominate	VERB
admet-579	88	6	the	the	DET
admet-579	88	7	pk	pk	NOUN
admet-579	88	8	of	of	ADP
admet-579	88	9	the	the	DET
admet-579	88	10	hls	hls	PROPN
admet-579	88	11	is	be	AUX
admet-579	88	12	the	the	DET
admet-579	88	13	adipose	adipose	ADJ
admet-579	88	14	tissue	tissue	NOUN
admet-579	88	15	volume	volume	NOUN
admet-579	88	16	and	and	CCONJ
admet-579	88	17	blood	blood	NOUN
admet-579	88	18	flow	flow	NOUN
admet-579	88	19	.	.	PUNCT
admet-579	89	1	it	it	PRON
admet-579	89	2	is	be	AUX
admet-579	89	3	essential	essential	ADJ
admet-579	89	4	that	that	SCONJ
admet-579	89	5	the	the	DET
admet-579	89	6	magnitude	magnitude	NOUN
admet-579	89	7	of	of	ADP
admet-579	89	8	the	the	DET
admet-579	89	9	heterogeneity	heterogeneity	NOUN
admet-579	89	10	(	(	PUNCT
admet-579	89	11	if	if	SCONJ
admet-579	89	12	any	any	PRON
admet-579	89	13	)	)	PUNCT
admet-579	89	14	of	of	ADP
admet-579	89	15	adipose	adipose	ADP
admet-579	89	16	blood	blood	NOUN
admet-579	89	17	flow	flow	NOUN
admet-579	89	18	is	be	AUX
admet-579	89	19	included	include	VERB
admet-579	89	20	in	in	ADP
admet-579	89	21	the	the	DET
admet-579	89	22	pbpk	pbpk	ADJ
admet-579	89	23	model	model	NOUN
admet-579	89	24	.	.	PUNCT
admet-579	90	1	the	the	DET
admet-579	90	2	time	time	NOUN
admet-579	90	3	constant	constant	ADJ
admet-579	90	4	(	(	PUNCT
admet-579	90	5	t	t	NOUN
admet-579	90	6	)	)	PUNCT
admet-579	90	7	for	for	ADP
admet-579	90	8	adipose	adipose	PRON
admet-579	90	9	tissue	tissue	NOUN
admet-579	90	10	equilibration	equilibration	NOUN
admet-579	90	11	is	be	AUX
admet-579	90	12	described	describe	VERB
admet-579	90	13	by	by	ADP
admet-579	90	14	(	(	PUNCT
admet-579	90	15	assuming	assume	VERB
admet-579	90	16	a	a	DET
admet-579	90	17	well	well	ADV
admet-579	90	18	-	-	PUNCT
admet-579	90	19	mixed	mixed	ADJ
admet-579	90	20	,	,	PUNCT
admet-579	90	21	flow	flow	NOUN
admet-579	90	22	limited	limited	ADJ
admet-579	90	23	tissue	tissue	NOUN
admet-579	90	24	):	):	PUNCT
admet-579	90	25	david	david	PROPN
admet-579	90	26	levitt	levitt	PROPN
admet-579	90	27	admet	admet	PROPN
admet-579	90	28	&	&	CCONJ
admet-579	90	29	dmpk	dmpk	PROPN
admet-579	90	30	7(1	7(1	PROPN
admet-579	90	31	)	)	PUNCT
admet-579	90	32	(	(	PUNCT
admet-579	90	33	2019)60	2019)60	NUM
admet-579	90	34	-	-	SYM
admet-579	90	35	75	75	NUM
admet-579	90	36	64	64	NUM
admet-579	90	37	adiposeweight	adiposeweight	NOUN
admet-579	90	38	(	(	PUNCT
admet-579	90	39	adipose	adipose	NOUN
admet-579	90	40	/	/	SYM
admet-579	90	41	bloodpartition	bloodpartition	NOUN
admet-579	90	42	)	)	PUNCT
admet-579	91	1	adiposebloodflow	adiposebloodflow	NOUN
admet-579	91	2	t	t	PROPN
admet-579	91	3			NUM
admet-579	91	4	(	(	PUNCT
admet-579	91	5	4	4	NUM
admet-579	91	6	)	)	PUNCT
admet-579	91	7	the	the	DET
admet-579	91	8	units	unit	NOUN
admet-579	91	9	are	be	AUX
admet-579	91	10	kg	kg	NOUN
admet-579	91	11	for	for	ADP
admet-579	91	12	adipose	adipose	NOUN
admet-579	91	13	weight	weight	NOUN
admet-579	91	14	,	,	PUNCT
admet-579	91	15	and	and	CCONJ
admet-579	91	16	kg	kg	PROPN
admet-579	91	17	/	/	SYM
admet-579	91	18	min	min	NOUN
admet-579	91	19	for	for	ADP
admet-579	91	20	blood	blood	NOUN
admet-579	91	21	flow	flow	NOUN
admet-579	91	22	while	while	SCONJ
admet-579	91	23	the	the	DET
admet-579	91	24	adipose	adipose	NOUN
admet-579	91	25	/	/	SYM
admet-579	91	26	blood	blood	NOUN
admet-579	91	27	partition	partition	NOUN
admet-579	91	28	is	be	AUX
admet-579	91	29	dimensionless	dimensionless	NOUN
admet-579	91	30	.	.	PUNCT
admet-579	92	1	for	for	ADP
admet-579	92	2	the	the	DET
admet-579	92	3	volatile	volatile	ADJ
admet-579	92	4	anesthetics	anesthetic	NOUN
admet-579	92	5	t	t	NOUN
admet-579	92	6	ranges	range	VERB
admet-579	92	7	from	from	ADP
admet-579	92	8	about	about	ADP
admet-579	92	9	500	500	NUM
admet-579	92	10	min	min	NOUN
admet-579	92	11	to	to	ADP
admet-579	92	12	3	3	NUM
admet-579	92	13	days	day	NOUN
admet-579	92	14	.	.	PUNCT
admet-579	93	1	at	at	ADP
admet-579	93	2	early	early	ADJ
admet-579	93	3	times	time	NOUN
admet-579	93	4	(	(	PUNCT
admet-579	93	5	several	several	ADJ
admet-579	93	6	hours	hour	NOUN
admet-579	93	7	)	)	PUNCT
admet-579	93	8	before	before	SCONJ
admet-579	93	9	the	the	DET
admet-579	93	10	lipid	lipid	NOUN
admet-579	93	11	becomes	becomes	AUX
admet-579	93	12	saturated	saturate	VERB
admet-579	93	13	,	,	PUNCT
admet-579	93	14	the	the	DET
admet-579	93	15	adipose	adipose	ADJ
admet-579	93	16	tissue	tissue	NOUN
admet-579	93	17	behaves	behave	VERB
admet-579	93	18	like	like	ADP
admet-579	93	19	an	an	DET
admet-579	93	20	infinite	infinite	ADJ
admet-579	93	21	sink	sink	NOUN
admet-579	93	22	and	and	CCONJ
admet-579	93	23	the	the	DET
admet-579	93	24	pk	pk	NOUN
admet-579	93	25	is	be	AUX
admet-579	93	26	not	not	PART
admet-579	93	27	dependent	dependent	ADJ
admet-579	93	28	on	on	ADP
admet-579	93	29	the	the	DET
admet-579	93	30	heterogeneity	heterogeneity	NOUN
admet-579	93	31	.	.	PUNCT
admet-579	94	1	it	it	PRON
admet-579	94	2	is	be	AUX
admet-579	94	3	only	only	ADV
admet-579	94	4	at	at	ADP
admet-579	94	5	times	time	NOUN
admet-579	94	6	that	that	PRON
admet-579	94	7	are	be	AUX
admet-579	94	8	long	long	ADV
admet-579	94	9	relative	relative	ADJ
admet-579	94	10	to	to	ADP
admet-579	94	11	t	t	NOUN
admet-579	94	12	that	that	SCONJ
admet-579	94	13	the	the	DET
admet-579	94	14	heterogeneity	heterogeneity	NOUN
admet-579	94	15	becomes	become	VERB
admet-579	94	16	apparent	apparent	ADJ
admet-579	94	17	.	.	PUNCT
admet-579	95	1	thus	thus	ADV
admet-579	95	2	,	,	PUNCT
admet-579	95	3	in	in	ADP
admet-579	95	4	order	order	NOUN
admet-579	95	5	to	to	PART
admet-579	95	6	determine	determine	VERB
admet-579	95	7	adipose	adipose	ADJ
admet-579	95	8	perfusion	perfusion	NOUN
admet-579	95	9	heterogeneity	heterogeneity	NOUN
admet-579	95	10	it	it	PRON
admet-579	95	11	is	be	AUX
admet-579	95	12	necessary	necessary	ADJ
admet-579	95	13	to	to	PART
admet-579	95	14	have	have	VERB
admet-579	95	15	pk	pk	NOUN
admet-579	95	16	measurements	measurement	NOUN
admet-579	95	17	that	that	PRON
admet-579	95	18	extend	extend	VERB
admet-579	95	19	to	to	ADP
admet-579	95	20	days	day	NOUN
admet-579	95	21	.	.	PUNCT
admet-579	96	1	probably	probably	ADV
admet-579	96	2	the	the	DET
admet-579	96	3	best	well	ADV
admet-579	96	4	available	available	ADJ
admet-579	96	5	set	set	NOUN
admet-579	96	6	of	of	ADP
admet-579	96	7	measurements	measurement	NOUN
admet-579	96	8	of	of	ADP
admet-579	96	9	this	this	DET
admet-579	96	10	kind	kind	NOUN
admet-579	96	11	is	be	AUX
admet-579	96	12	the	the	DET
admet-579	96	13	remarkable	remarkable	ADJ
admet-579	96	14	series	series	NOUN
admet-579	96	15	of	of	ADP
admet-579	96	16	studies	study	NOUN
admet-579	96	17	of	of	ADP
admet-579	96	18	the	the	DET
admet-579	96	19	pk	pk	NOUN
admet-579	96	20	of	of	ADP
admet-579	96	21	the	the	DET
admet-579	96	22	volatile	volatile	ADJ
admet-579	96	23	anesthetics	anesthetic	NOUN
admet-579	96	24	isoflurane	isoflurane	NOUN
admet-579	96	25	,	,	PUNCT
admet-579	96	26	sevoflurane	sevoflurane	NOUN
admet-579	96	27	and	and	CCONJ
admet-579	96	28	desflurane	desflurane	NOUN
admet-579	96	29	by	by	ADP
admet-579	96	30	eger	eger	NOUN
admet-579	96	31	and	and	CCONJ
admet-579	96	32	colleagues	colleague	NOUN
admet-579	96	33	[	[	X
admet-579	96	34	14	14	NUM
admet-579	96	35	,	,	PUNCT
admet-579	96	36	15	15	NUM
admet-579	96	37	]	]	PUNCT
admet-579	96	38	.	.	PUNCT
admet-579	97	1	they	they	PRON
admet-579	97	2	measured	measure	VERB
admet-579	97	3	the	the	DET
admet-579	97	4	ventilation	ventilation	NOUN
admet-579	97	5	rate	rate	NOUN
admet-579	97	6	and	and	CCONJ
admet-579	97	7	the	the	DET
admet-579	97	8	inspired	inspire	VERB
admet-579	97	9	,	,	PUNCT
admet-579	97	10	mixed	mixed	ADJ
admet-579	97	11	and	and	CCONJ
admet-579	97	12	end	end	VERB
admet-579	97	13	tidal	tidal	ADJ
admet-579	97	14	gas	gas	NOUN
admet-579	97	15	concentration	concentration	NOUN
admet-579	97	16	for	for	ADP
admet-579	97	17	6	6	NUM
admet-579	97	18	days	day	NOUN
admet-579	97	19	following	follow	VERB
admet-579	97	20	a	a	DET
admet-579	97	21	30	30	NUM
admet-579	97	22	minute	minute	NOUN
admet-579	97	23	uptake	uptake	NOUN
admet-579	97	24	in	in	ADP
admet-579	97	25	normal	normal	ADJ
admet-579	97	26	volunteers	volunteer	NOUN
admet-579	97	27	.	.	PUNCT
admet-579	98	1	dr	dr	PROPN
admet-579	98	2	.	.	PROPN
admet-579	98	3	eger	eger	PROPN
admet-579	98	4	kindly	kindly	ADV
admet-579	98	5	provided	provide	VERB
admet-579	98	6	this	this	DET
admet-579	98	7	data	datum	NOUN
admet-579	98	8	which	which	PRON
admet-579	98	9	was	be	AUX
admet-579	98	10	then	then	ADV
admet-579	98	11	modeled	model	VERB
admet-579	98	12	using	use	VERB
admet-579	98	13	pkquest	pkquest	NOUN
admet-579	98	14	to	to	PART
admet-579	98	15	estimate	estimate	VERB
admet-579	98	16	the	the	DET
admet-579	98	17	adipose	adipose	ADJ
admet-579	98	18	perfusion	perfusion	NOUN
admet-579	98	19	heterogeneity	heterogeneity	NOUN
admet-579	98	20	.	.	PUNCT
admet-579	99	1	the	the	DET
admet-579	99	2	analysis	analysis	NOUN
admet-579	99	3	indicated	indicate	VERB
admet-579	99	4	that	that	SCONJ
admet-579	99	5	at	at	ADV
admet-579	99	6	least	least	ADV
admet-579	99	7	two	two	NUM
admet-579	99	8	equal	equal	ADJ
admet-579	99	9	volume	volume	NOUN
admet-579	99	10	adipose	adipose	ADP
admet-579	99	11	compartments	compartment	NOUN
admet-579	99	12	with	with	ADP
admet-579	99	13	perfusion	perfusion	NOUN
admet-579	99	14	rates	rate	NOUN
admet-579	99	15	of	of	ADP
admet-579	99	16	0.074	0.074	NUM
admet-579	99	17	and	and	CCONJ
admet-579	99	18	0.014	0.014	NUM
admet-579	99	19	l	l	NOUN
admet-579	99	20	/	/	SYM
admet-579	99	21	kg	kg	NOUN
admet-579	99	22	/	/	SYM
admet-579	99	23	min	min	NOUN
admet-579	99	24	were	be	AUX
admet-579	99	25	needed	need	VERB
admet-579	99	26	to	to	PART
admet-579	99	27	accurately	accurately	ADV
admet-579	99	28	model	model	VERB
admet-579	99	29	the	the	DET
admet-579	99	30	long	long	ADJ
admet-579	99	31	time	time	NOUN
admet-579	99	32	data[10	data[10	X
admet-579	99	33	]	]	PUNCT
admet-579	99	34	and	and	CCONJ
admet-579	99	35	these	these	PRON
admet-579	99	36	are	be	AUX
admet-579	99	37	the	the	DET
admet-579	99	38	default	default	NOUN
admet-579	99	39	values	value	NOUN
admet-579	99	40	in	in	ADP
admet-579	99	41	pkquest	pkqu	ADJ
admet-579	99	42	(	(	PUNCT
admet-579	99	43	table	table	NOUN
admet-579	99	44	1	1	NUM
admet-579	99	45	)	)	PUNCT
admet-579	99	46	.	.	PUNCT
admet-579	100	1	figure	figure	NOUN
admet-579	100	2	2	2	NUM
admet-579	100	3	.	.	PUNCT
admet-579	100	4	pkquest	pkqu	ADJ
admet-579	100	5	interface	interface	NOUN
admet-579	100	6	.	.	PUNCT
admet-579	101	1	the	the	DET
admet-579	101	2	top	top	ADJ
admet-579	101	3	panel	panel	NOUN
admet-579	101	4	lists	list	VERB
admet-579	101	5	all	all	DET
admet-579	101	6	the	the	DET
admet-579	101	7	input	input	NOUN
admet-579	101	8	required	require	VERB
admet-579	101	9	to	to	PART
admet-579	101	10	specify	specify	VERB
admet-579	101	11	the	the	DET
admet-579	101	12	pbpk	pbpk	ADJ
admet-579	101	13	pharmacokinetics	pharmacokinetic	NOUN
admet-579	101	14	for	for	ADP
admet-579	101	15	isoflurane	isoflurane	NOUN
admet-579	101	16	(	(	PUNCT
admet-579	101	17	see	see	VERB
admet-579	101	18	text	text	NOUN
admet-579	101	19	for	for	ADP
admet-579	101	20	details	detail	NOUN
admet-579	101	21	)	)	PUNCT
admet-579	101	22	.	.	PUNCT
admet-579	102	1	figure	figure	NOUN
admet-579	102	2	2	2	NUM
admet-579	102	3	shows	show	VERB
admet-579	102	4	the	the	DET
admet-579	102	5	interactive	interactive	ADJ
admet-579	102	6	pkquest	pkqu	ADJ
admet-579	102	7	interface	interface	NOUN
admet-579	102	8	for	for	ADP
admet-579	102	9	isoflurane	isoflurane	NOUN
admet-579	102	10	.	.	PUNCT
admet-579	103	1	the	the	DET
admet-579	103	2	isoflurane	isoflurane	ADJ
admet-579	103	3	kinetics	kinetic	NOUN
admet-579	103	4	are	be	AUX
admet-579	103	5	completely	completely	ADV
admet-579	103	6	characterized	characterize	VERB
admet-579	103	7	by	by	ADP
admet-579	103	8	the	the	DET
admet-579	103	9	entries	entry	NOUN
admet-579	103	10	in	in	ADP
admet-579	103	11	the	the	DET
admet-579	103	12	top	top	ADJ
admet-579	103	13	panel	panel	NOUN
admet-579	103	14	.	.	PUNCT
admet-579	104	1	the	the	DET
admet-579	104	2	check	check	NOUN
admet-579	104	3	box	box	PROPN
admet-579	104	4	“	"	PUNCT
admet-579	104	5	volatile	volatile	ADJ
admet-579	104	6	”	"	PUNCT
admet-579	104	7	turns	turn	VERB
admet-579	104	8	on	on	ADP
admet-579	104	9	the	the	DET
admet-579	104	10	pbpk	pbpk	NOUN
admet-579	104	11	for	for	ADP
admet-579	104	12	volatile	volatile	ADJ
admet-579	104	13	solutes	solute	NOUN
admet-579	104	14	(	(	PUNCT
admet-579	104	15	which	which	PRON
admet-579	104	16	are	be	AUX
admet-579	104	17	,	,	PUNCT
admet-579	104	18	presumably	presumably	ADV
admet-579	104	19	,	,	PUNCT
admet-579	104	20	also	also	ADV
admet-579	104	21	hls	hls	NOUN
admet-579	104	22	)	)	PUNCT
admet-579	104	23	.	.	PUNCT
admet-579	105	1	setting	set	VERB
admet-579	105	2	kbair	kbair	NOUN
admet-579	105	3	,	,	PUNCT
admet-579	105	4	kwair	kwair	NOUN
admet-579	105	5	,	,	PUNCT
admet-579	105	6	kfwat	kfwat	NOUN
admet-579	105	7	characterizes	characterize	VERB
admet-579	105	8	isoflurane	isoflurane	NOUN
admet-579	105	9	.	.	PUNCT
admet-579	106	1	the	the	DET
admet-579	106	2	parameters	parameter	NOUN
admet-579	106	3	vent	vent	VERB
admet-579	106	4	(	(	PUNCT
admet-579	106	5	alveolar	alveolar	ADJ
admet-579	106	6	ventilation	ventilation	NOUN
admet-579	106	7	)	)	PUNCT
admet-579	106	8	and	and	CCONJ
admet-579	106	9	vol	vol	NOUN
admet-579	106	10	(	(	PUNCT
admet-579	106	11	alveolar	alveolar	ADJ
admet-579	106	12	volume	volume	NOUN
admet-579	106	13	)	)	PUNCT
admet-579	106	14	are	be	AUX
admet-579	106	15	the	the	DET
admet-579	106	16	standard	standard	ADJ
admet-579	106	17	70	70	NUM
admet-579	106	18	kg	kg	NOUN
admet-579	106	19	human	human	ADJ
admet-579	106	20	values	value	NOUN
admet-579	106	21	.	.	PUNCT
admet-579	107	1	the	the	DET
admet-579	107	2	entries	entry	NOUN
admet-579	107	3	in	in	ADP
admet-579	107	4	the	the	DET
admet-579	107	5	other	other	ADJ
admet-579	107	6	panels	panel	NOUN
admet-579	107	7	describe	describe	VERB
admet-579	107	8	the	the	DET
admet-579	107	9	details	detail	NOUN
admet-579	107	10	of	of	ADP
admet-579	107	11	the	the	DET
admet-579	107	12	dose	dose	NOUN
admet-579	107	13	regimen	regiman	NOUN
admet-579	107	14	and	and	CCONJ
admet-579	107	15	the	the	DET
admet-579	107	16	variables	variable	NOUN
admet-579	107	17	that	that	PRON
admet-579	107	18	should	should	AUX
admet-579	107	19	be	be	AUX
admet-579	107	20	admet	admet	PROPN
admet-579	107	21	&	&	CCONJ
admet-579	107	22	dmpk	dmpk	PROPN
admet-579	107	23	7(1	7(1	PROPN
admet-579	107	24	)	)	PUNCT
admet-579	107	25	(	(	PUNCT
admet-579	107	26	2019	2019	NUM
admet-579	107	27	)	)	PUNCT
admet-579	107	28	60	60	NUM
admet-579	107	29	-	-	SYM
admet-579	107	30	75	75	NUM
admet-579	107	31	lipid	lipid	NOUN
admet-579	107	32	soluble	soluble	ADJ
admet-579	107	33	and	and	CCONJ
admet-579	107	34	extracellular	extracellular	ADJ
admet-579	107	35	solutes	solute	NOUN
admet-579	107	36	doi	doi	NOUN
admet-579	107	37	:	:	PUNCT
admet-579	107	38	10.5599	10.5599	NUM
admet-579	107	39	/	/	SYM
admet-579	107	40	admet.579	admet.579	NOUN
admet-579	107	41	65	65	NUM
admet-579	107	42	plotted	plot	VERB
admet-579	107	43	in	in	ADP
admet-579	107	44	the	the	DET
admet-579	107	45	output	output	NOUN
admet-579	107	46	.	.	PUNCT
admet-579	108	1	figures	figure	NOUN
admet-579	108	2	3	3	NUM
admet-579	108	3	and	and	CCONJ
admet-579	108	4	4	4	NUM
admet-579	108	5	show	show	VERB
admet-579	108	6	semi	semi	ADJ
admet-579	108	7	-	-	ADJ
admet-579	108	8	log	log	ADJ
admet-579	108	9	plots	plot	NOUN
admet-579	108	10	of	of	ADP
admet-579	108	11	the	the	DET
admet-579	108	12	pkquest	pkqu	ADJ
admet-579	108	13	pbpk	pbpk	ADJ
admet-579	108	14	prediction	prediction	NOUN
admet-579	108	15	of	of	ADP
admet-579	108	16	the	the	DET
admet-579	108	17	short	short	ADJ
admet-579	108	18	and	and	CCONJ
admet-579	108	19	long	long	ADJ
admet-579	108	20	time	time	NOUN
admet-579	108	21	expired	expire	VERB
admet-579	108	22	partial	partial	ADJ
admet-579	108	23	pressure	pressure	NOUN
admet-579	108	24	(	(	PUNCT
admet-579	108	25	pexpired	pexpire	VERB
admet-579	108	26	)	)	PUNCT
admet-579	108	27	relative	relative	ADJ
admet-579	108	28	to	to	ADP
admet-579	108	29	the	the	DET
admet-579	108	30	pinspired	pinspire	VERB
admet-579	108	31	during	during	ADP
admet-579	108	32	the	the	DET
admet-579	108	33	30	30	NUM
admet-579	108	34	minute	minute	NOUN
admet-579	108	35	uptake	uptake	ADJ
admet-579	108	36	period	period	NOUN
admet-579	108	37	for	for	ADP
admet-579	108	38	isoflurane	isoflurane	NOUN
admet-579	108	39	,	,	PUNCT
admet-579	108	40	sevoflurane	sevoflurane	NOUN
admet-579	108	41	and	and	CCONJ
admet-579	108	42	desflurane	desflurane	NOUN
admet-579	108	43	.	.	PUNCT
admet-579	109	1	it	it	PRON
admet-579	109	2	can	can	AUX
admet-579	109	3	be	be	AUX
admet-579	109	4	seen	see	VERB
admet-579	109	5	that	that	SCONJ
admet-579	109	6	,	,	PUNCT
admet-579	109	7	although	although	SCONJ
admet-579	109	8	these	these	DET
admet-579	109	9	3	3	NUM
admet-579	109	10	anesthetics	anesthetic	NOUN
admet-579	109	11	have	have	VERB
admet-579	109	12	significantly	significantly	ADV
admet-579	109	13	different	different	ADJ
admet-579	109	14	properties	property	NOUN
admet-579	109	15	(	(	PUNCT
admet-579	109	16	blood	blood	NOUN
admet-579	109	17	/	/	SYM
admet-579	109	18	air	air	NOUN
admet-579	109	19	and	and	CCONJ
admet-579	109	20	oil	oil	NOUN
admet-579	109	21	/	/	SYM
admet-579	109	22	air	air	NOUN
admet-579	109	23	partition	partition	NOUN
admet-579	109	24	)	)	PUNCT
admet-579	109	25	,	,	PUNCT
admet-579	109	26	the	the	DET
admet-579	109	27	human	human	ADJ
admet-579	109	28	pk	pk	NOUN
admet-579	109	29	can	can	AUX
admet-579	109	30	be	be	AUX
admet-579	109	31	accurately	accurately	ADV
admet-579	109	32	fit	fit	ADJ
admet-579	109	33	using	use	VERB
admet-579	109	34	the	the	DET
admet-579	109	35	same	same	ADJ
admet-579	109	36	default	default	NOUN
admet-579	109	37	pbpk	pbpk	NOUN
admet-579	109	38	model	model	NOUN
admet-579	109	39	with	with	ADP
admet-579	109	40	no	no	DET
admet-579	109	41	adjustable	adjustable	ADJ
admet-579	109	42	parameters	parameter	NOUN
admet-579	109	43	.	.	PUNCT
admet-579	110	1	pbpk	pbpk	NOUN
admet-579	110	2	analysis	analysis	NOUN
admet-579	110	3	is	be	AUX
admet-579	110	4	ideally	ideally	ADV
admet-579	110	5	suited	suit	VERB
admet-579	110	6	for	for	ADP
admet-579	110	7	modeling	model	VERB
admet-579	110	8	the	the	DET
admet-579	110	9	volatile	volatile	ADJ
admet-579	110	10	anesthetics	anesthetic	NOUN
admet-579	110	11	and	and	CCONJ
admet-579	110	12	has	have	VERB
admet-579	110	13	clear	clear	ADJ
admet-579	110	14	advantages	advantage	NOUN
admet-579	110	15	over	over	ADP
admet-579	110	16	the	the	DET
admet-579	110	17	5	5	NUM
admet-579	110	18	compartment	compartment	NOUN
admet-579	110	19	mammillary	mammillary	ADJ
admet-579	110	20	model	model	NOUN
admet-579	110	21	with	with	ADP
admet-579	110	22	10	10	NUM
admet-579	110	23	adjustable	adjustable	ADJ
admet-579	110	24	parameters	parameter	NOUN
admet-579	110	25	that	that	PRON
admet-579	110	26	is	be	AUX
admet-579	110	27	classically	classically	ADV
admet-579	110	28	used	use	VERB
admet-579	110	29	for	for	ADP
admet-579	110	30	these	these	DET
admet-579	110	31	solutes	solute	NOUN
admet-579	110	32	[	[	X
admet-579	110	33	14	14	NUM
admet-579	110	34	,	,	PUNCT
admet-579	110	35	15	15	NUM
admet-579	110	36	]	]	PUNCT
admet-579	110	37	.	.	PUNCT
admet-579	111	1	figure	figure	VERB
admet-579	111	2	3	3	NUM
admet-579	111	3	.	.	PUNCT
admet-579	111	4	pkquest	pkqu	ADJ
admet-579	111	5	pbpk	pbpk	ADJ
admet-579	111	6	predictions	prediction	NOUN
admet-579	111	7	(	(	PUNCT
admet-579	111	8	black	black	ADJ
admet-579	111	9	line	line	NOUN
admet-579	111	10	)	)	PUNCT
admet-579	111	11	of	of	ADP
admet-579	111	12	short	short	ADJ
admet-579	111	13	time	time	NOUN
admet-579	111	14	pharmacokinetics	pharmacokinetic	NOUN
admet-579	111	15	of	of	ADP
admet-579	111	16	isoflurane	isoflurane	NOUN
admet-579	111	17	,	,	PUNCT
admet-579	111	18	sevoflurane	sevoflurane	NOUN
admet-579	111	19	and	and	CCONJ
admet-579	111	20	desflurane	desflurane	NOUN
admet-579	111	21	using	use	VERB
admet-579	111	22	the	the	DET
admet-579	111	23	identical	identical	ADJ
admet-579	111	24	basic	basic	ADJ
admet-579	111	25	pbpk	pbpk	ADJ
admet-579	111	26	model	model	NOUN
admet-579	111	27	with	with	ADP
admet-579	111	28	two	two	NUM
admet-579	111	29	equal	equal	ADJ
admet-579	111	30	weight	weight	NOUN
admet-579	111	31	adipose	adipose	ADP
admet-579	111	32	organs	organ	NOUN
admet-579	111	33	with	with	ADP
admet-579	111	34	blood	blood	NOUN
admet-579	111	35	perfusions	perfusion	NOUN
admet-579	111	36	of	of	ADP
admet-579	111	37	0.014	0.014	NUM
admet-579	111	38	and	and	CCONJ
admet-579	111	39	0.074	0.074	NUM
admet-579	111	40	l	l	NOUN
admet-579	111	41	/	/	SYM
admet-579	111	42	kg	kg	PROPN
admet-579	111	43	/	/	SYM
admet-579	111	44	min	min	PROPN
admet-579	111	45	.	.	PROPN
admet-579	111	46	isofluranes	isoflurane	NOUN
admet-579	111	47	and	and	CCONJ
admet-579	111	48	isofluraned	isoflurane	VERB
admet-579	111	49	refer	refer	NOUN
admet-579	111	50	to	to	ADP
admet-579	111	51	two	two	NUM
admet-579	111	52	different	different	ADJ
admet-579	111	53	sets	set	NOUN
admet-579	111	54	of	of	ADP
admet-579	111	55	data	datum	NOUN
admet-579	111	56	.	.	PUNCT
admet-579	112	1	this	this	DET
admet-579	112	2	same	same	ADJ
admet-579	112	3	set	set	NOUN
admet-579	112	4	of	of	ADP
admet-579	112	5	pbpk	pbpk	ADJ
admet-579	112	6	organ	organ	NOUN
admet-579	112	7	parameters	parameter	NOUN
admet-579	112	8	is	be	AUX
admet-579	112	9	also	also	ADV
admet-579	112	10	applicable	applicable	ADJ
admet-579	112	11	to	to	ADP
admet-579	112	12	non	non	ADJ
admet-579	112	13	-	-	ADJ
admet-579	112	14	volatile	volatile	ADJ
admet-579	112	15	hls	hls	NOUN
admet-579	112	16	.	.	PUNCT
admet-579	113	1	figure	figure	NOUN
admet-579	113	2	5	5	NUM
admet-579	113	3	shows	show	VERB
admet-579	113	4	the	the	DET
admet-579	113	5	pkquest	pkqu	ADJ
admet-579	113	6	interface	interface	PROPN
admet-579	113	7	top	top	ADJ
admet-579	113	8	panel	panel	NOUN
admet-579	113	9	for	for	ADP
admet-579	113	10	cannabinol	cannabinol	NOUN
admet-579	113	11	.	.	PUNCT
admet-579	114	1	the	the	DET
admet-579	114	2	“	"	PUNCT
admet-579	114	3	fat	fat	ADJ
admet-579	114	4	/	/	SYM
admet-579	114	5	water	water	NOUN
admet-579	114	6	partition	partition	NOUN
admet-579	114	7	”	"	PUNCT
admet-579	114	8	check	check	NOUN
admet-579	114	9	box	box	NOUN
admet-579	114	10	turns	turn	VERB
admet-579	114	11	on	on	ADP
admet-579	114	12	the	the	DET
admet-579	114	13	hls	hls	NOUN
admet-579	114	14	option	option	NOUN
admet-579	114	15	.	.	PUNCT
admet-579	115	1	cannabinol	cannabinol	PROPN
admet-579	115	2	has	have	VERB
admet-579	115	3	a	a	DET
admet-579	115	4	very	very	ADV
admet-579	115	5	high	high	ADJ
admet-579	115	6	oil	oil	NOUN
admet-579	115	7	/	/	SYM
admet-579	115	8	water	water	NOUN
admet-579	115	9	partition	partition	NOUN
admet-579	115	10	of	of	ADP
admet-579	115	11	about	about	ADV
admet-579	115	12	200,000	200,000	NUM
admet-579	115	13	[	[	SYM
admet-579	115	14	10	10	NUM
admet-579	115	15	]	]	PUNCT
admet-579	115	16	(	(	PUNCT
admet-579	115	17	input	input	NOUN
admet-579	115	18	in	in	ADP
admet-579	115	19	the	the	DET
admet-579	115	20	“	"	PUNCT
admet-579	115	21	kfwat	kfwat	NOUN
admet-579	115	22	”	"	PUNCT
admet-579	115	23	box	box	NOUN
admet-579	115	24	.	.	PUNCT
admet-579	115	25	)	)	PUNCT
admet-579	115	26	.	.	PUNCT
admet-579	116	1	only	only	ADV
admet-579	116	2	two	two	NUM
admet-579	116	3	adjustable	adjustable	ADJ
admet-579	116	4	parameters	parameter	NOUN
admet-579	116	5	were	be	AUX
admet-579	116	6	required	require	VERB
admet-579	116	7	to	to	PART
admet-579	116	8	provide	provide	VERB
admet-579	116	9	a	a	DET
admet-579	116	10	good	good	ADJ
admet-579	116	11	fit	fit	NOUN
admet-579	116	12	to	to	ADP
admet-579	116	13	the	the	DET
admet-579	116	14	pk	pk	NOUN
admet-579	116	15	data	datum	NOUN
admet-579	116	16	of	of	ADP
admet-579	116	17	johansson	johansson	PROPN
admet-579	116	18	et	et	PROPN
admet-579	116	19	.	.	PUNCT
admet-579	117	1	al	al	PROPN
admet-579	117	2	.	.	PUNCT
admet-579	118	1	[	[	X
admet-579	118	2	16	16	NUM
admet-579	118	3	]	]	X
admet-579	118	4	:	:	PUNCT
admet-579	118	5	the	the	DET
admet-579	118	6	fractional	fractional	ADJ
admet-579	118	7	liver	liver	NOUN
admet-579	118	8	clearance	clearance	NOUN
admet-579	118	9	(	(	PUNCT
admet-579	118	10	0.651	0.651	NUM
admet-579	118	11	)	)	PUNCT
admet-579	118	12	and	and	CCONJ
admet-579	118	13	the	the	DET
admet-579	118	14	blood	blood	NOUN
admet-579	118	15	fat	fat	NOUN
admet-579	118	16	fraction	fraction	NOUN
admet-579	118	17	(	(	PUNCT
admet-579	118	18	0.0075	0.0075	NUM
admet-579	118	19	)	)	PUNCT
admet-579	118	20	.	.	PUNCT
admet-579	119	1	figure	figure	NOUN
admet-579	119	2	6	6	NUM
admet-579	119	3	is	be	AUX
admet-579	119	4	the	the	DET
admet-579	119	5	pkquest	pkqu	ADJ
admet-579	119	6	output	output	NOUN
admet-579	119	7	showing	show	VERB
admet-579	119	8	the	the	DET
admet-579	119	9	pkquest	pkqu	ADJ
admet-579	119	10	fit	fit	NOUN
admet-579	119	11	to	to	ADP
admet-579	119	12	this	this	DET
admet-579	119	13	data	datum	NOUN
admet-579	119	14	.	.	PUNCT
admet-579	120	1	david	david	PROPN
admet-579	120	2	levitt	levitt	PROPN
admet-579	120	3	admet	admet	PROPN
admet-579	120	4	&	&	CCONJ
admet-579	120	5	dmpk	dmpk	PROPN
admet-579	120	6	7(1	7(1	PROPN
admet-579	120	7	)	)	PUNCT
admet-579	120	8	(	(	PUNCT
admet-579	120	9	2019)60	2019)60	NUM
admet-579	120	10	-	-	SYM
admet-579	120	11	75	75	NUM
admet-579	120	12	66	66	NUM
admet-579	120	13	figure	figure	NOUN
admet-579	120	14	4	4	NUM
admet-579	120	15	.	.	PUNCT
admet-579	120	16	pkquest	pkqu	ADJ
admet-579	120	17	pbpk	pbpk	ADJ
admet-579	120	18	predictions	prediction	NOUN
admet-579	120	19	(	(	PUNCT
admet-579	120	20	black	black	ADJ
admet-579	120	21	line	line	NOUN
admet-579	120	22	)	)	PUNCT
admet-579	120	23	of	of	ADP
admet-579	120	24	long	long	ADJ
admet-579	120	25	time	time	NOUN
admet-579	120	26	pharmacokinetics	pharmacokinetic	NOUN
admet-579	120	27	of	of	ADP
admet-579	120	28	isoflurane	isoflurane	NOUN
admet-579	120	29	,	,	PUNCT
admet-579	120	30	sevoflurane	sevoflurane	NOUN
admet-579	120	31	and	and	CCONJ
admet-579	120	32	desflurane	desflurane	NOUN
admet-579	120	33	using	use	VERB
admet-579	120	34	the	the	DET
admet-579	120	35	identical	identical	ADJ
admet-579	120	36	basic	basic	ADJ
admet-579	120	37	pbpk	pbpk	ADJ
admet-579	120	38	model	model	NOUN
admet-579	120	39	with	with	ADP
admet-579	120	40	two	two	NUM
admet-579	120	41	equal	equal	ADJ
admet-579	120	42	weight	weight	NOUN
admet-579	120	43	adipose	adipose	ADP
admet-579	120	44	organs	organ	NOUN
admet-579	120	45	with	with	ADP
admet-579	120	46	blood	blood	NOUN
admet-579	120	47	perfusions	perfusion	NOUN
admet-579	120	48	of	of	ADP
admet-579	120	49	0.014	0.014	NUM
admet-579	120	50	and	and	CCONJ
admet-579	120	51	0.074	0.074	NUM
admet-579	120	52	l	l	NOUN
admet-579	120	53	/	/	SYM
admet-579	120	54	kg	kg	PROPN
admet-579	120	55	/	/	SYM
admet-579	120	56	min	min	PROPN
admet-579	120	57	.	.	PROPN
admet-579	120	58	isofluranes	isoflurane	NOUN
admet-579	120	59	and	and	CCONJ
admet-579	120	60	isofluraned	isoflurane	VERB
admet-579	120	61	refer	refer	NOUN
admet-579	120	62	to	to	ADP
admet-579	120	63	two	two	NUM
admet-579	120	64	different	different	ADJ
admet-579	120	65	sets	set	NOUN
admet-579	120	66	of	of	ADP
admet-579	120	67	data	datum	NOUN
admet-579	120	68	.	.	PUNCT
admet-579	121	1	figure	figure	NOUN
admet-579	121	2	5	5	NUM
admet-579	121	3	.	.	PUNCT
admet-579	121	4	top	top	ADJ
admet-579	121	5	panel	panel	NOUN
admet-579	121	6	of	of	ADP
admet-579	121	7	the	the	DET
admet-579	121	8	pkquest	pkqu	ADJ
admet-579	121	9	interface	interface	NOUN
admet-579	121	10	for	for	ADP
admet-579	121	11	cannabinol	cannabinol	NOUN
admet-579	121	12	(	(	PUNCT
admet-579	121	13	see	see	VERB
admet-579	121	14	text	text	NOUN
admet-579	121	15	for	for	ADP
admet-579	121	16	details	detail	NOUN
admet-579	121	17	)	)	PUNCT
admet-579	121	18	an	an	DET
admet-579	121	19	important	important	ADJ
admet-579	121	20	clinical	clinical	ADJ
admet-579	121	21	application	application	NOUN
admet-579	121	22	of	of	ADP
admet-579	121	23	the	the	DET
admet-579	121	24	pbpk	pbpk	ADJ
admet-579	121	25	hls	hls	NOUN
admet-579	121	26	model	model	NOUN
admet-579	121	27	is	be	AUX
admet-579	121	28	in	in	ADP
admet-579	121	29	predicting	predict	VERB
admet-579	121	30	the	the	DET
admet-579	121	31	pk	pk	NOUN
admet-579	121	32	of	of	ADP
admet-579	121	33	anesthetics	anesthetic	NOUN
admet-579	121	34	in	in	ADP
admet-579	121	35	obese	obese	ADJ
admet-579	121	36	subjects	subject	NOUN
admet-579	121	37	.	.	PUNCT
admet-579	122	1	the	the	DET
admet-579	122	2	prediction	prediction	NOUN
admet-579	122	3	is	be	AUX
admet-579	122	4	obtained	obtain	VERB
admet-579	122	5	simply	simply	ADV
admet-579	122	6	by	by	ADP
admet-579	122	7	changing	change	VERB
admet-579	122	8	the	the	DET
admet-579	122	9	“	"	PUNCT
admet-579	122	10	fat	fat	ADJ
admet-579	122	11	fr	fr	NOUN
admet-579	122	12	”	"	PUNCT
admet-579	122	13	entry	entry	NOUN
admet-579	122	14	in	in	ADP
admet-579	122	15	the	the	DET
admet-579	122	16	pkquest	pkqu	ADJ
admet-579	122	17	interface	interface	NOUN
admet-579	122	18	(	(	PUNCT
admet-579	122	19	figs	fig	NOUN
admet-579	122	20	.	.	X
admet-579	123	1	2	2	NUM
admet-579	123	2	and	and	CCONJ
admet-579	123	3	5	5	NUM
admet-579	123	4	)	)	PUNCT
admet-579	123	5	.	.	PUNCT
admet-579	124	1	figures	figure	NOUN
admet-579	124	2	7	7	NUM
admet-579	124	3	and	and	CCONJ
admet-579	124	4	8	8	NUM
admet-579	124	5	show	show	VERB
admet-579	124	6	two	two	NUM
admet-579	124	7	examples	example	NOUN
admet-579	124	8	obtained	obtain	VERB
admet-579	124	9	from	from	ADP
admet-579	124	10	the	the	DET
admet-579	124	11	pkquest	pkqu	ADJ
admet-579	124	12	analysis	analysis	NOUN
admet-579	124	13	of	of	ADP
admet-579	124	14	propofol	propofol	NOUN
admet-579	124	15	[	[	X
admet-579	124	16	17	17	NUM
admet-579	124	17	]	]	PUNCT
admet-579	124	18	.	.	PUNCT
admet-579	125	1	servin	servin	PROPN
admet-579	125	2	et	et	PROPN
admet-579	125	3	.	.	PUNCT
admet-579	126	1	al	al	PROPN
admet-579	126	2	.	.	PUNCT
admet-579	127	1	[	[	X
admet-579	127	2	18	18	NUM
admet-579	127	3	]	]	PUNCT
admet-579	127	4	had	have	AUX
admet-579	127	5	previously	previously	ADV
admet-579	127	6	shown	show	VERB
admet-579	127	7	that	that	SCONJ
admet-579	127	8	the	the	DET
admet-579	127	9	“	"	PUNCT
admet-579	127	10	eye	eye	NOUN
admet-579	127	11	opening	opening	NOUN
admet-579	127	12	”	"	PUNCT
admet-579	127	13	time	time	NOUN
admet-579	127	14	following	follow	VERB
admet-579	127	15	a	a	DET
admet-579	127	16	180	180	NUM
admet-579	127	17	minute	minute	NOUN
admet-579	127	18	propofol	propofol	NOUN
admet-579	127	19	infusion	infusion	NOUN
admet-579	127	20	was	be	AUX
admet-579	127	21	shorter	short	ADJ
admet-579	127	22	in	in	ADP
admet-579	127	23	obese	obese	ADJ
admet-579	127	24	subjects	subject	NOUN
admet-579	127	25	(	(	PUNCT
admet-579	127	26	10.3	10.3	NUM
admet-579	127	27	min	min	NOUN
admet-579	127	28	)	)	PUNCT
admet-579	127	29	versus	versus	ADP
admet-579	127	30	normal	normal	ADJ
admet-579	127	31	weight	weight	NOUN
admet-579	127	32	subjects	subject	NOUN
admet-579	127	33	(	(	PUNCT
admet-579	127	34	18.4	18.4	NUM
admet-579	127	35	min	min	NOUN
admet-579	127	36	)	)	PUNCT
admet-579	127	37	.	.	PUNCT
admet-579	128	1	figure	figure	VERB
admet-579	128	2	7	7	NUM
admet-579	128	3	shows	show	VERB
admet-579	128	4	that	that	SCONJ
admet-579	128	5	the	the	DET
admet-579	128	6	pbpk	pbpk	PROPN
admet-579	128	7	model	model	NOUN
admet-579	128	8	provides	provide	VERB
admet-579	128	9	a	a	DET
admet-579	128	10	similar	similar	ADJ
admet-579	128	11	prediction	prediction	NOUN
admet-579	128	12	.	.	PUNCT
admet-579	129	1	propofol	propofol	NOUN
admet-579	129	2	is	be	AUX
admet-579	129	3	routinely	routinely	ADV
admet-579	129	4	used	use	VERB
admet-579	129	5	for	for	ADP
admet-579	129	6	long	long	ADJ
admet-579	129	7	term	term	NOUN
admet-579	129	8	sedation	sedation	NOUN
admet-579	129	9	.	.	PUNCT
admet-579	130	1	figure	figure	NOUN
admet-579	130	2	8	8	NUM
admet-579	130	3	shows	show	NOUN
admet-579	130	4	admet	admet	PROPN
admet-579	130	5	&	&	CCONJ
admet-579	130	6	dmpk	dmpk	PROPN
admet-579	130	7	7(1	7(1	PROPN
admet-579	130	8	)	)	PUNCT
admet-579	130	9	(	(	PUNCT
admet-579	130	10	2019	2019	NUM
admet-579	130	11	)	)	PUNCT
admet-579	130	12	60	60	NUM
admet-579	130	13	-	-	SYM
admet-579	130	14	75	75	NUM
admet-579	130	15	lipid	lipid	NOUN
admet-579	130	16	soluble	soluble	ADJ
admet-579	130	17	and	and	CCONJ
admet-579	130	18	extracellular	extracellular	ADJ
admet-579	130	19	solutes	solute	NOUN
admet-579	130	20	doi	doi	NOUN
admet-579	130	21	:	:	PUNCT
admet-579	130	22	10.5599	10.5599	NUM
admet-579	130	23	/	/	SYM
admet-579	130	24	admet.579	admet.579	NOUN
admet-579	130	25	67	67	NUM
admet-579	130	26	the	the	DET
admet-579	130	27	arterial	arterial	ADJ
admet-579	130	28	concentration	concentration	NOUN
admet-579	130	29	during	during	ADP
admet-579	130	30	the	the	DET
admet-579	130	31	washout	washout	NOUN
admet-579	130	32	period	period	NOUN
admet-579	130	33	following	follow	VERB
admet-579	130	34	a	a	DET
admet-579	130	35	10	10	NUM
admet-579	130	36	day	day	NOUN
admet-579	130	37	constant	constant	ADJ
admet-579	130	38	infusion	infusion	NOUN
admet-579	130	39	.	.	PUNCT
admet-579	131	1	it	it	PRON
admet-579	131	2	can	can	AUX
admet-579	131	3	be	be	AUX
admet-579	131	4	seen	see	VERB
admet-579	131	5	that	that	SCONJ
admet-579	131	6	in	in	ADP
admet-579	131	7	obese	obese	ADJ
admet-579	131	8	subjects	subject	NOUN
admet-579	131	9	(	(	PUNCT
admet-579	131	10	red	red	PROPN
admet-579	131	11	)	)	PUNCT
admet-579	131	12	the	the	DET
admet-579	131	13	washout	washout	NOUN
admet-579	131	14	is	be	AUX
admet-579	131	15	markedly	markedly	ADV
admet-579	131	16	slower	slow	ADJ
admet-579	131	17	with	with	ADP
admet-579	131	18	a	a	DET
admet-579	131	19	greatly	greatly	ADV
admet-579	131	20	prolonged	prolonged	ADJ
admet-579	131	21	waking	waking	NOUN
admet-579	131	22	time	time	NOUN
admet-579	131	23	.	.	PUNCT
admet-579	132	1	in	in	ADP
admet-579	132	2	determining	determine	VERB
admet-579	132	3	the	the	DET
admet-579	132	4	pk	pk	NOUN
admet-579	132	5	for	for	ADP
admet-579	132	6	the	the	DET
admet-579	132	7	obese	obese	ADJ
admet-579	132	8	subjects	subject	NOUN
admet-579	132	9	,	,	PUNCT
admet-579	132	10	it	it	PRON
admet-579	132	11	is	be	AUX
admet-579	132	12	assumed	assume	VERB
admet-579	132	13	that	that	SCONJ
admet-579	132	14	the	the	DET
admet-579	132	15	standard	standard	ADJ
admet-579	132	16	human	human	ADJ
admet-579	132	17	tissue	tissue	NOUN
admet-579	132	18	parameters	parameter	NOUN
admet-579	132	19	,	,	PUNCT
admet-579	132	20	including	include	VERB
admet-579	132	21	those	those	PRON
admet-579	132	22	for	for	ADP
admet-579	132	23	“	"	PUNCT
admet-579	132	24	adipose1	adipose1	PROPN
admet-579	132	25	”	"	PUNCT
admet-579	132	26	and	and	CCONJ
admet-579	132	27	“	"	PUNCT
admet-579	132	28	adipose2	adipose2	PROPN
admet-579	132	29	”	"	PUNCT
admet-579	132	30	(	(	PUNCT
admet-579	132	31	table	table	NOUN
admet-579	132	32	1	1	NUM
admet-579	132	33	)	)	PUNCT
admet-579	132	34	can	can	AUX
admet-579	132	35	be	be	AUX
admet-579	132	36	extrapolated	extrapolate	VERB
admet-579	132	37	to	to	ADP
admet-579	132	38	the	the	DET
admet-579	132	39	obese	obese	ADJ
admet-579	132	40	subjects	subject	NOUN
admet-579	132	41	.	.	PUNCT
admet-579	133	1	this	this	PRON
admet-579	133	2	is	be	AUX
admet-579	133	3	a	a	DET
admet-579	133	4	major	major	ADJ
admet-579	133	5	limitation	limitation	NOUN
admet-579	133	6	because	because	SCONJ
admet-579	133	7	a	a	DET
admet-579	133	8	careful	careful	ADJ
admet-579	133	9	evaluation	evaluation	NOUN
admet-579	133	10	of	of	ADP
admet-579	133	11	these	these	DET
admet-579	133	12	parameters	parameter	NOUN
admet-579	133	13	is	be	AUX
admet-579	133	14	not	not	PART
admet-579	133	15	available	available	ADJ
admet-579	133	16	for	for	ADP
admet-579	133	17	these	these	DET
admet-579	133	18	subjects	subject	NOUN
admet-579	133	19	.	.	PUNCT
admet-579	134	1	figure	figure	VERB
admet-579	134	2	6	6	NUM
admet-579	134	3	.	.	PUNCT
admet-579	134	4	pkquest	pkqu	ADJ
admet-579	134	5	pbpk	pbpk	ADJ
admet-579	134	6	predictions	prediction	NOUN
admet-579	134	7	(	(	PUNCT
admet-579	134	8	red	red	ADJ
admet-579	134	9	line	line	NOUN
admet-579	134	10	)	)	PUNCT
admet-579	134	11	of	of	ADP
admet-579	134	12	pharmacokinetics	pharmacokinetic	NOUN
admet-579	134	13	of	of	ADP
admet-579	134	14	cannabinol	cannabinol	NOUN
admet-579	134	15	figure	figure	NOUN
admet-579	134	16	7	7	NUM
admet-579	134	17	.	.	PUNCT
admet-579	134	18	plot	plot	NOUN
admet-579	134	19	of	of	ADP
admet-579	134	20	arterial	arterial	ADJ
admet-579	134	21	blood	blood	NOUN
admet-579	134	22	propofol	propofol	NOUN
admet-579	134	23	concentration	concentration	NOUN
admet-579	134	24	in	in	ADP
admet-579	134	25	normal	normal	ADJ
admet-579	134	26	weight	weight	NOUN
admet-579	134	27	(	(	PUNCT
admet-579	134	28	black	black	NOUN
admet-579	134	29	)	)	PUNCT
admet-579	134	30	and	and	CCONJ
admet-579	134	31	morbidly	morbidly	ADV
admet-579	134	32	obese	obese	ADJ
admet-579	134	33	subjects	subject	NOUN
admet-579	134	34	(	(	PUNCT
admet-579	134	35	red	red	ADJ
admet-579	134	36	)	)	PUNCT
admet-579	134	37	following	follow	VERB
admet-579	134	38	a	a	DET
admet-579	134	39	180	180	NUM
admet-579	134	40	minute	minute	NOUN
admet-579	134	41	propofol	propofol	NOUN
admet-579	134	42	infusion	infusion	NOUN
admet-579	134	43	.	.	PUNCT
admet-579	135	1	at	at	ADP
admet-579	135	2	a	a	DET
admet-579	135	3	time	time	NOUN
admet-579	135	4	of	of	ADP
admet-579	135	5	180	180	NUM
admet-579	135	6	minutes	minute	NOUN
admet-579	135	7	,	,	PUNCT
admet-579	135	8	the	the	DET
admet-579	135	9	constant	constant	ADJ
admet-579	135	10	propofol	propofol	NOUN
admet-579	135	11	infusion	infusion	NOUN
admet-579	135	12	is	be	AUX
admet-579	135	13	terminated	terminate	VERB
admet-579	135	14	.	.	PUNCT
admet-579	136	1	the	the	DET
admet-579	136	2	time	time	NOUN
admet-579	136	3	for	for	SCONJ
admet-579	136	4	the	the	DET
admet-579	136	5	arterial	arterial	ADJ
admet-579	136	6	level	level	NOUN
admet-579	136	7	to	to	PART
admet-579	136	8	drop	drop	VERB
admet-579	136	9	below	below	ADP
admet-579	136	10	the	the	DET
admet-579	136	11	“	"	PUNCT
admet-579	136	12	eye	eye	NOUN
admet-579	136	13	opening	opening	NOUN
admet-579	136	14	concentration	concentration	NOUN
admet-579	136	15	”	"	PUNCT
admet-579	136	16	is	be	AUX
admet-579	136	17	about	about	ADV
admet-579	136	18	5	5	NUM
admet-579	136	19	minutes	minute	NOUN
admet-579	136	20	for	for	ADP
admet-579	136	21	the	the	DET
admet-579	136	22	obese	obese	NOUN
admet-579	136	23	and	and	CCONJ
admet-579	136	24	13	13	NUM
admet-579	136	25	minutes	minute	NOUN
admet-579	136	26	for	for	ADP
admet-579	136	27	the	the	DET
admet-579	136	28	normal	normal	ADJ
admet-579	136	29	subjects	subject	NOUN
admet-579	136	30	david	david	PROPN
admet-579	136	31	levitt	levitt	PROPN
admet-579	136	32	admet	admet	PROPN
admet-579	136	33	&	&	CCONJ
admet-579	136	34	dmpk	dmpk	PROPN
admet-579	136	35	7(1	7(1	PROPN
admet-579	136	36	)	)	PUNCT
admet-579	136	37	(	(	PUNCT
admet-579	136	38	2019)60	2019)60	NUM
admet-579	136	39	-	-	SYM
admet-579	136	40	75	75	NUM
admet-579	136	41	68	68	NUM
admet-579	136	42	figure	figure	NOUN
admet-579	136	43	8	8	NUM
admet-579	136	44	.	.	PUNCT
admet-579	136	45	comparison	comparison	NOUN
admet-579	136	46	of	of	ADP
admet-579	136	47	arterial	arterial	ADJ
admet-579	136	48	propofol	propofol	NOUN
admet-579	136	49	concentration	concentration	NOUN
admet-579	136	50	in	in	ADP
admet-579	136	51	normal	normal	ADJ
admet-579	136	52	(	(	PUNCT
admet-579	136	53	black	black	NOUN
admet-579	136	54	)	)	PUNCT
admet-579	136	55	and	and	CCONJ
admet-579	136	56	obese	obese	ADJ
admet-579	136	57	(	(	PUNCT
admet-579	136	58	red	red	ADJ
admet-579	136	59	)	)	PUNCT
admet-579	136	60	subjects	subject	NOUN
admet-579	136	61	during	during	ADP
admet-579	136	62	washout	washout	NOUN
admet-579	136	63	following	follow	VERB
admet-579	136	64	a	a	DET
admet-579	136	65	10	10	NUM
admet-579	136	66	day	day	NOUN
admet-579	136	67	(	(	PUNCT
admet-579	136	68	14,400	14,400	NUM
admet-579	136	69	minutes	minute	NOUN
admet-579	136	70	)	)	PUNCT
admet-579	136	71	constant	constant	ADJ
admet-579	136	72	infusion	infusion	NOUN
admet-579	136	73	.	.	PUNCT
admet-579	137	1	the	the	DET
admet-579	137	2	constant	constant	ADJ
admet-579	137	3	infusion	infusion	NOUN
admet-579	137	4	rate	rate	NOUN
admet-579	137	5	has	have	AUX
admet-579	137	6	been	be	AUX
admet-579	137	7	adjusted	adjust	VERB
admet-579	137	8	so	so	SCONJ
admet-579	137	9	that	that	SCONJ
admet-579	137	10	the	the	DET
admet-579	137	11	concentrations	concentration	NOUN
admet-579	137	12	at	at	ADP
admet-579	137	13	the	the	DET
admet-579	137	14	end	end	NOUN
admet-579	137	15	of	of	ADP
admet-579	137	16	the	the	DET
admet-579	137	17	10	10	NUM
admet-579	137	18	day	day	NOUN
admet-579	137	19	period	period	NOUN
admet-579	137	20	are	be	AUX
admet-579	137	21	identical	identical	ADJ
admet-579	137	22	for	for	ADP
admet-579	137	23	the	the	DET
admet-579	137	24	normal	normal	ADJ
admet-579	137	25	and	and	CCONJ
admet-579	137	26	obese	obese	ADJ
admet-579	137	27	subjects	subject	NOUN
admet-579	137	28	.	.	PUNCT
admet-579	138	1	the	the	DET
admet-579	138	2	extreme	extreme	ADJ
admet-579	138	3	limit	limit	NOUN
admet-579	138	4	of	of	ADP
admet-579	138	5	hls	hls	NOUN
admet-579	138	6	solutes	solute	NOUN
admet-579	138	7	are	be	AUX
admet-579	138	8	the	the	DET
admet-579	138	9	persistent	persistent	ADJ
admet-579	138	10	organic	organic	ADJ
admet-579	138	11	pollutants	pollutant	NOUN
admet-579	138	12	(	(	PUNCT
admet-579	138	13	pop	pop	NOUN
admet-579	138	14	)	)	PUNCT
admet-579	138	15	,	,	PUNCT
admet-579	138	16	such	such	ADJ
admet-579	138	17	as	as	ADP
admet-579	138	18	dioxins	dioxin	NOUN
admet-579	138	19	and	and	CCONJ
admet-579	138	20	polychlorinated	polychlorinate	VERB
admet-579	138	21	biphenyls	biphenyls	NOUN
admet-579	138	22	,	,	PUNCT
admet-579	138	23	which	which	PRON
admet-579	138	24	are	be	AUX
admet-579	138	25	characterized	characterize	VERB
admet-579	138	26	by	by	ADP
admet-579	138	27	human	human	ADJ
admet-579	138	28	life	life	NOUN
admet-579	138	29	times	time	NOUN
admet-579	138	30	of	of	ADP
admet-579	138	31	several	several	ADJ
admet-579	138	32	years	year	NOUN
admet-579	138	33	and	and	CCONJ
admet-579	138	34	have	have	VERB
admet-579	138	35	lipid	lipid	NOUN
admet-579	138	36	/	/	SYM
admet-579	138	37	water	water	NOUN
admet-579	138	38	(	(	PUNCT
admet-579	138	39	pl	pl	NOUN
admet-579	138	40	/	/	SYM
admet-579	138	41	w	w	NOUN
admet-579	138	42	)	)	PUNCT
admet-579	138	43	partition	partition	NOUN
admet-579	138	44	ranging	range	VERB
admet-579	138	45	from	from	ADP
admet-579	138	46	10	10	NUM
admet-579	138	47	5	5	NUM
admet-579	138	48	to	to	ADP
admet-579	138	49	greater	great	ADJ
admet-579	138	50	than	than	ADP
admet-579	138	51	10	10	NUM
admet-579	138	52	7	7	NUM
admet-579	138	53	[	[	X
admet-579	138	54	12	12	NUM
admet-579	138	55	]	]	PUNCT
admet-579	138	56	.	.	PUNCT
admet-579	139	1	because	because	SCONJ
admet-579	139	2	of	of	ADP
admet-579	139	3	these	these	DET
admet-579	139	4	long	long	ADJ
admet-579	139	5	lifetimes	lifetime	NOUN
admet-579	139	6	and	and	CCONJ
admet-579	139	7	the	the	DET
admet-579	139	8	near	near	ADJ
admet-579	139	9	impossibility	impossibility	NOUN
admet-579	139	10	of	of	ADP
admet-579	139	11	obtaining	obtain	VERB
admet-579	139	12	accurate	accurate	ADJ
admet-579	139	13	experimental	experimental	ADJ
admet-579	139	14	human	human	PROPN
admet-579	139	15	pk	pk	PROPN
admet-579	139	16	data	datum	NOUN
admet-579	139	17	,	,	PUNCT
admet-579	139	18	pop	pop	VERB
admet-579	139	19	modeling	modeling	NOUN
admet-579	139	20	and	and	CCONJ
admet-579	139	21	prediction	prediction	NOUN
admet-579	139	22	has	have	AUX
admet-579	139	23	become	become	VERB
admet-579	139	24	one	one	NUM
admet-579	139	25	of	of	ADP
admet-579	139	26	the	the	DET
admet-579	139	27	most	most	ADV
admet-579	139	28	important	important	ADJ
admet-579	139	29	pbpk	pbpk	ADJ
admet-579	139	30	applications	application	NOUN
admet-579	139	31	.	.	PUNCT
admet-579	140	1	there	there	PRON
admet-579	140	2	is	be	VERB
admet-579	140	3	a	a	DET
admet-579	140	4	common	common	ADJ
admet-579	140	5	misperception	misperception	NOUN
admet-579	140	6	that	that	SCONJ
admet-579	140	7	the	the	DET
admet-579	140	8	long	long	ADJ
admet-579	140	9	lifetimes	lifetime	NOUN
admet-579	140	10	results	result	NOUN
admet-579	140	11	,	,	PUNCT
admet-579	140	12	primarily	primarily	ADV
admet-579	140	13	,	,	PUNCT
admet-579	140	14	from	from	ADP
admet-579	140	15	their	their	PRON
admet-579	140	16	very	very	ADV
admet-579	140	17	high	high	ADJ
admet-579	140	18	lipid	lipid	NOUN
admet-579	140	19	partition	partition	NOUN
admet-579	140	20	and	and	CCONJ
admet-579	140	21	resultant	resultant	VERB
admet-579	140	22	slow	slow	ADJ
admet-579	140	23	adipose	adipose	PRON
admet-579	140	24	tissue	tissue	NOUN
admet-579	140	25	washout	washout	NOUN
admet-579	141	1	[	[	X
admet-579	141	2	19	19	NUM
admet-579	141	3	]	]	PUNCT
admet-579	141	4	.	.	PUNCT
admet-579	142	1	what	what	PRON
admet-579	142	2	is	be	AUX
admet-579	142	3	not	not	PART
admet-579	142	4	commonly	commonly	ADV
admet-579	142	5	recognized	recognize	VERB
admet-579	142	6	is	be	AUX
admet-579	142	7	that	that	SCONJ
admet-579	142	8	,	,	PUNCT
admet-579	142	9	as	as	SCONJ
admet-579	142	10	described	describe	VERB
admet-579	142	11	in	in	ADP
admet-579	142	12	eq	eq	ADP
admet-579	142	13	.	.	PUNCT
admet-579	143	1	(	(	PUNCT
admet-579	143	2	3	3	NUM
admet-579	143	3	)	)	PUNCT
admet-579	143	4	,	,	PUNCT
admet-579	143	5	for	for	ADP
admet-579	143	6	pl	pl	PROPN
admet-579	143	7	/	/	SYM
admet-579	143	8	w	w	NOUN
admet-579	143	9	greater	great	ADJ
admet-579	143	10	than	than	ADP
admet-579	143	11	about	about	ADP
admet-579	143	12	1000	1000	NUM
admet-579	143	13	,	,	PUNCT
admet-579	143	14	kadipose	kadipose	NOUN
admet-579	143	15	reaches	reach	VERB
admet-579	143	16	a	a	DET
admet-579	143	17	maximum	maximum	ADJ
admet-579	143	18	value	value	NOUN
admet-579	143	19	equal	equal	ADJ
admet-579	143	20	to	to	ADP
admet-579	143	21	fl	fl	NUM
admet-579	143	22	adipose	adipose	VERB
admet-579	143	23	/	/	SYM
admet-579	143	24	fl	fl	NOUN
admet-579	143	25	blood	blood	NOUN
admet-579	143	26	,	,	PUNCT
admet-579	143	27	and	and	CCONJ
admet-579	143	28	further	further	ADJ
admet-579	143	29	increases	increase	NOUN
admet-579	143	30	in	in	ADP
admet-579	143	31	pl	pl	PROPN
admet-579	143	32	/	/	SYM
admet-579	143	33	w	w	NOUN
admet-579	143	34	do	do	AUX
admet-579	143	35	not	not	PART
admet-579	143	36	increase	increase	VERB
admet-579	143	37	it	it	PRON
admet-579	143	38	above	above	ADP
admet-579	143	39	this	this	DET
admet-579	143	40	maximum	maximum	ADJ
admet-579	143	41	value	value	NOUN
admet-579	143	42	described	describe	VERB
admet-579	143	43	by	by	ADP
admet-579	143	44	:	:	PUNCT
admet-579	143	45	:	:	PUNCT
admet-579	143	46	l	l	X
admet-579	143	47	/	/	SYM
admet-579	143	48	w	w	NOUN
admet-579	143	49	adipose	adipose	X
admet-579	143	50	adipose	adipose	PRON
admet-579	143	51	blood	blood	NOUN
admet-579	143	52	l	l	NOUN
admet-579	143	53	l1000	l1000	PROPN
admet-579	143	54	/	/	SYM
admet-579	143	55	0.8	0.8	NUM
admet-579	143	56	/	/	SYM
admet-579	143	57	0.005	0.005	NUM
admet-579	143	58	160	160	NUM
admet-579	144	1	p	p	NOUN
admet-579	145	1	k	k	NOUN
admet-579	146	1	f	f	PROPN
admet-579	147	1	f	f	PROPN
admet-579	148	1			PROPN
admet-579	148	2			NUM
admet-579	148	3			NUM
admet-579	148	4			NOUN
admet-579	148	5	(	(	PUNCT
admet-579	148	6	5	5	NUM
admet-579	148	7	)	)	PUNCT
admet-579	148	8	substituting	substitute	VERB
admet-579	148	9	this	this	DET
admet-579	148	10	relation	relation	NOUN
admet-579	148	11	for	for	ADP
admet-579	148	12	the	the	DET
admet-579	148	13	maximum	maximum	ADJ
admet-579	148	14	value	value	NOUN
admet-579	148	15	of	of	ADP
admet-579	148	16	kadipose	kadipose	NOUN
admet-579	148	17	into	into	ADP
admet-579	148	18	eq	eq	PROPN
admet-579	148	19	.	.	PUNCT
admet-579	149	1	(	(	PUNCT
admet-579	149	2	4	4	NUM
admet-579	149	3	)	)	PUNCT
admet-579	149	4	,	,	PUNCT
admet-579	149	5	the	the	DET
admet-579	149	6	longest	long	ADV
admet-579	149	7	possible	possible	ADJ
admet-579	149	8	time	time	NOUN
admet-579	149	9	constant	constant	ADJ
admet-579	149	10	for	for	ADP
admet-579	149	11	flow	flow	NOUN
admet-579	149	12	-	-	PUNCT
admet-579	149	13	limited	limit	VERB
admet-579	149	14	adipose	adipose	ADJ
admet-579	149	15	washout	washout	NOUN
admet-579	149	16	is	be	AUX
admet-579	149	17	:	:	PUNCT
admet-579	150	1	l	l	X
admet-579	150	2	/	/	SYM
admet-579	150	3	w	w	NOUN
admet-579	150	4	adipose	adipose	ADP
admet-579	150	5	1	1	NUM
admet-579	150	6	adipose	adipose	NOUN
admet-579	150	7	adipose	adipose	ADP
admet-579	150	8	1000	1000	NUM
admet-579	150	9	/	/	SYM
admet-579	150	10	160	160	NUM
admet-579	150	11	/	/	SYM
admet-579	150	12	0.01min	0.01min	NOUN
admet-579	150	13	16,000min	16,000min	NUM
admet-579	150	14	11days	11days	NUM
admet-579	150	15	p	p	X
admet-579	150	16	t	t	PROPN
admet-579	151	1	k	k	PROPN
admet-579	151	2	f	f	PROPN
admet-579	151	3			PROPN
admet-579	151	4			VERB
admet-579	151	5			PROPN
admet-579	151	6			NUM
admet-579	152	1			NUM
admet-579	152	2			NOUN
admet-579	152	3	(	(	PUNCT
admet-579	152	4	6	6	NUM
admet-579	152	5	)	)	PUNCT
admet-579	152	6	where	where	SCONJ
admet-579	152	7	fadipose	fadipose	NOUN
admet-579	152	8	is	be	AUX
admet-579	152	9	the	the	DET
admet-579	152	10	adipose	adipose	ADJ
admet-579	152	11	perfusion	perfusion	NOUN
admet-579	152	12	rate	rate	NOUN
admet-579	152	13	.	.	PUNCT
admet-579	153	1	thus	thus	ADV
admet-579	153	2	,	,	PUNCT
admet-579	153	3	high	high	ADJ
admet-579	153	4	lipid	lipid	NOUN
admet-579	153	5	partition	partition	NOUN
admet-579	153	6	can	can	AUX
admet-579	153	7	only	only	ADV
admet-579	153	8	account	account	VERB
admet-579	153	9	for	for	ADP
admet-579	153	10	washout	washout	NOUN
admet-579	153	11	time	time	NOUN
admet-579	153	12	constants	constant	NOUN
admet-579	153	13	of	of	ADP
admet-579	153	14	about	about	ADV
admet-579	153	15	11	11	NUM
admet-579	153	16	days	day	NOUN
admet-579	153	17	,	,	PUNCT
admet-579	153	18	much	much	ADV
admet-579	153	19	shorter	short	ADJ
admet-579	153	20	than	than	ADP
admet-579	153	21	the	the	DET
admet-579	153	22	year	year	NOUN
admet-579	153	23	or	or	CCONJ
admet-579	153	24	more	more	ADJ
admet-579	153	25	that	that	PRON
admet-579	153	26	is	be	AUX
admet-579	153	27	observed	observe	VERB
admet-579	153	28	for	for	ADP
admet-579	153	29	many	many	ADJ
admet-579	153	30	pops	pop	NOUN
admet-579	153	31	.	.	PUNCT
admet-579	154	1	one	one	NUM
admet-579	154	2	possible	possible	ADJ
admet-579	154	3	explanation	explanation	NOUN
admet-579	154	4	is	be	AUX
admet-579	154	5	that	that	PRON
admet-579	154	6	eq	eq	ADJ
admet-579	154	7	.	.	PUNCT
admet-579	155	1	(	(	PUNCT
admet-579	155	2	6	6	NUM
admet-579	155	3	)	)	PUNCT
admet-579	155	4	is	be	AUX
admet-579	155	5	incorrect	incorrect	ADJ
admet-579	155	6	because	because	SCONJ
admet-579	155	7	it	it	PRON
admet-579	155	8	assumed	assume	VERB
admet-579	155	9	that	that	SCONJ
admet-579	155	10	the	the	DET
admet-579	155	11	adipose	adipose	ADJ
admet-579	155	12	/	/	SYM
admet-579	155	13	blood	blood	NOUN
admet-579	155	14	exchange	exchange	NOUN
admet-579	155	15	is	be	AUX
admet-579	155	16	flow	flow	NOUN
admet-579	155	17	limited	limited	ADJ
admet-579	155	18	,	,	PUNCT
admet-579	155	19	while	while	SCONJ
admet-579	155	20	,	,	PUNCT
admet-579	155	21	as	as	SCONJ
admet-579	155	22	clearly	clearly	ADV
admet-579	155	23	shown	show	VERB
admet-579	155	24	by	by	ADP
admet-579	155	25	levitt	levitt	PROPN
admet-579	156	1	[	[	X
admet-579	156	2	12	12	NUM
admet-579	156	3	]	]	PUNCT
admet-579	156	4	,	,	PUNCT
admet-579	156	5	it	it	PRON
admet-579	156	6	becomes	become	VERB
admet-579	156	7	diffusion	diffusion	NOUN
admet-579	156	8	limited	limit	VERB
admet-579	156	9	for	for	ADP
admet-579	156	10	some	some	DET
admet-579	156	11	pops	pop	NOUN
admet-579	156	12	.	.	PUNCT
admet-579	157	1	this	this	DET
admet-579	157	2	diffusion	diffusion	NOUN
admet-579	157	3	limitation	limitation	NOUN
admet-579	157	4	arises	arise	VERB
admet-579	157	5	because	because	SCONJ
admet-579	157	6	the	the	DET
admet-579	157	7	high	high	ADJ
admet-579	157	8	pl	pl	PROPN
admet-579	157	9	/	/	SYM
admet-579	157	10	w	w	PROPN
admet-579	157	11	of	of	ADP
admet-579	157	12	the	the	DET
admet-579	157	13	pop	pop	NOUN
admet-579	157	14	produces	produce	VERB
admet-579	157	15	such	such	DET
admet-579	157	16	a	a	DET
admet-579	157	17	low	low	ADJ
admet-579	157	18	free	free	ADJ
admet-579	157	19	water	water	NOUN
admet-579	157	20	concentration	concentration	NOUN
admet-579	157	21	that	that	DET
admet-579	157	22	diffusion	diffusion	NOUN
admet-579	157	23	through	through	ADP
admet-579	157	24	the	the	DET
admet-579	157	25	capillary	capillary	ADJ
admet-579	157	26	wall	wall	NOUN
admet-579	157	27	becomes	become	VERB
admet-579	157	28	rate	rate	NOUN
admet-579	157	29	limiting	limiting	NOUN
admet-579	157	30	.	.	PUNCT
admet-579	158	1	however	however	ADV
admet-579	158	2	,	,	PUNCT
admet-579	158	3	even	even	ADV
admet-579	158	4	taking	take	VERB
admet-579	158	5	admet	admet	PROPN
admet-579	158	6	&	&	CCONJ
admet-579	158	7	dmpk	dmpk	PROPN
admet-579	158	8	7(1	7(1	PROPN
admet-579	158	9	)	)	PUNCT
admet-579	158	10	(	(	PUNCT
admet-579	158	11	2019	2019	NUM
admet-579	158	12	)	)	PUNCT
admet-579	158	13	60	60	NUM
admet-579	158	14	-	-	SYM
admet-579	158	15	75	75	NUM
admet-579	158	16	lipid	lipid	NOUN
admet-579	158	17	soluble	soluble	ADJ
admet-579	158	18	and	and	CCONJ
admet-579	158	19	extracellular	extracellular	ADJ
admet-579	158	20	solutes	solute	NOUN
admet-579	158	21	doi	doi	NOUN
admet-579	158	22	:	:	PUNCT
admet-579	158	23	10.5599	10.5599	NUM
admet-579	158	24	/	/	SYM
admet-579	158	25	admet.579	admet.579	NOUN
admet-579	158	26	69	69	NUM
admet-579	158	27	account	account	NOUN
admet-579	158	28	of	of	ADP
admet-579	158	29	this	this	DET
admet-579	158	30	diffusion	diffusion	NOUN
admet-579	158	31	limitation	limitation	NOUN
admet-579	158	32	,	,	PUNCT
admet-579	158	33	the	the	DET
admet-579	158	34	adipose	adipose	ADJ
admet-579	158	35	exchange	exchange	NOUN
admet-579	158	36	time	time	NOUN
admet-579	158	37	constant	constant	ADJ
admet-579	158	38	is	be	AUX
admet-579	158	39	at	at	ADV
admet-579	158	40	least	least	ADJ
admet-579	158	41	10	10	NUM
admet-579	158	42	fold	fold	NOUN
admet-579	158	43	shorter	short	ADJ
admet-579	158	44	than	than	ADP
admet-579	158	45	the	the	DET
admet-579	158	46	pop	pop	NOUN
admet-579	158	47	lifetimes	lifetime	NOUN
admet-579	158	48	and	and	CCONJ
admet-579	158	49	can	can	AUX
admet-579	158	50	not	not	PART
admet-579	158	51	be	be	AUX
admet-579	158	52	responsible	responsible	ADJ
admet-579	158	53	for	for	ADP
admet-579	158	54	the	the	DET
admet-579	158	55	observed	observe	VERB
admet-579	158	56	human	human	ADJ
admet-579	158	57	pop	pop	NOUN
admet-579	158	58	persistence	persistence	NOUN
admet-579	158	59	[	[	X
admet-579	158	60	12	12	NUM
admet-579	158	61	]	]	PUNCT
admet-579	158	62	.	.	PUNCT
admet-579	159	1	the	the	DET
admet-579	159	2	explanation	explanation	NOUN
admet-579	159	3	of	of	ADP
admet-579	159	4	this	this	DET
admet-579	159	5	discrepancy	discrepancy	NOUN
admet-579	159	6	between	between	ADP
admet-579	159	7	the	the	DET
admet-579	159	8	adipose	adipose	ADJ
admet-579	159	9	pop	pop	ADJ
admet-579	159	10	time	time	NOUN
admet-579	159	11	constant	constant	ADJ
admet-579	159	12	and	and	CCONJ
admet-579	159	13	the	the	DET
admet-579	159	14	whole	whole	ADJ
admet-579	159	15	body	body	NOUN
admet-579	159	16	human	human	ADJ
admet-579	159	17	time	time	NOUN
admet-579	159	18	constant	constant	ADJ
admet-579	159	19	is	be	AUX
admet-579	159	20	simply	simply	ADV
admet-579	159	21	that	that	SCONJ
admet-579	159	22	the	the	DET
admet-579	159	23	pk	pk	NOUN
admet-579	159	24	of	of	ADP
admet-579	159	25	the	the	DET
admet-579	159	26	pops	pop	NOUN
admet-579	159	27	are	be	AUX
admet-579	159	28	limited	limit	VERB
admet-579	159	29	by	by	ADP
admet-579	159	30	their	their	PRON
admet-579	159	31	extremely	extremely	ADV
admet-579	159	32	low	low	ADJ
admet-579	159	33	rate	rate	NOUN
admet-579	159	34	of	of	ADP
admet-579	159	35	metabolism	metabolism	NOUN
admet-579	159	36	and	and	CCONJ
admet-579	159	37	excretion	excretion	NOUN
admet-579	159	38	,	,	PUNCT
admet-579	159	39	not	not	PART
admet-579	159	40	by	by	ADP
admet-579	159	41	the	the	DET
admet-579	159	42	adipose	adipose	NOUN
admet-579	159	43	/	/	SYM
admet-579	159	44	blood	blood	NOUN
admet-579	159	45	exchange	exchange	NOUN
admet-579	159	46	.	.	PUNCT
admet-579	160	1	as	as	SCONJ
admet-579	160	2	the	the	DET
admet-579	160	3	lipid	lipid	NOUN
admet-579	160	4	partition	partition	NOUN
admet-579	160	5	increases	increase	NOUN
admet-579	160	6	,	,	PUNCT
admet-579	160	7	the	the	DET
admet-579	160	8	free	free	ADJ
admet-579	160	9	water	water	NOUN
admet-579	160	10	concentration	concentration	NOUN
admet-579	160	11	in	in	ADP
admet-579	160	12	the	the	DET
admet-579	160	13	blood	blood	NOUN
admet-579	160	14	decreases	decrease	VERB
admet-579	160	15	and	and	CCONJ
admet-579	160	16	,	,	PUNCT
admet-579	160	17	presumably	presumably	ADV
admet-579	160	18	,	,	PUNCT
admet-579	160	19	the	the	DET
admet-579	160	20	rate	rate	NOUN
admet-579	160	21	of	of	ADP
admet-579	160	22	liver	liver	NOUN
admet-579	160	23	metabolism	metabolism	NOUN
admet-579	160	24	decreases	decrease	NOUN
admet-579	160	25	proportionally	proportionally	ADV
admet-579	160	26	.	.	PUNCT
admet-579	161	1	if	if	SCONJ
admet-579	161	2	the	the	DET
admet-579	161	3	metabolic	metabolic	NOUN
admet-579	161	4	time	time	NOUN
admet-579	161	5	constant	constant	ADJ
admet-579	161	6	for	for	ADP
admet-579	161	7	excretion	excretion	NOUN
admet-579	161	8	is	be	AUX
admet-579	161	9	long	long	ADV
admet-579	161	10	compared	compare	VERB
admet-579	161	11	to	to	ADP
admet-579	161	12	the	the	DET
admet-579	161	13	time	time	NOUN
admet-579	161	14	constant	constant	ADJ
admet-579	161	15	for	for	ADP
admet-579	161	16	adipose	adipose	NOUN
admet-579	161	17	and	and	CCONJ
admet-579	161	18	other	other	ADJ
admet-579	161	19	tissue	tissue	NOUN
admet-579	161	20	exchange	exchange	NOUN
admet-579	161	21	,	,	PUNCT
admet-579	161	22	then	then	ADV
admet-579	161	23	at	at	ADP
admet-579	161	24	long	long	ADJ
admet-579	161	25	times	time	NOUN
admet-579	161	26	,	,	PUNCT
admet-579	161	27	one	one	PRON
admet-579	161	28	can	can	AUX
admet-579	161	29	ignore	ignore	VERB
admet-579	161	30	the	the	DET
admet-579	161	31	pbpk	pbpk	PROPN
admet-579	161	32	model	model	NOUN
admet-579	161	33	details	detail	NOUN
admet-579	161	34	and	and	CCONJ
admet-579	161	35	the	the	DET
admet-579	161	36	plasma	plasma	NOUN
admet-579	161	37	concentration	concentration	NOUN
admet-579	161	38	can	can	AUX
admet-579	161	39	be	be	AUX
admet-579	161	40	described	describe	VERB
admet-579	161	41	by	by	ADP
admet-579	161	42	a	a	DET
admet-579	161	43	simple	simple	ADJ
admet-579	161	44	1	1	NUM
admet-579	161	45	-	-	PUNCT
admet-579	161	46	compartment	compartment	NOUN
admet-579	161	47	model	model	NOUN
admet-579	161	48	characterized	characterize	VERB
admet-579	161	49	by	by	ADP
admet-579	161	50	its	its	PRON
admet-579	161	51	clearance	clearance	NOUN
admet-579	161	52	(	(	PUNCT
admet-579	161	53	cl	cl	NOUN
admet-579	161	54	)	)	PUNCT
admet-579	161	55	and	and	CCONJ
admet-579	161	56	volume	volume	NOUN
admet-579	161	57	of	of	ADP
admet-579	161	58	distribution	distribution	NOUN
admet-579	161	59	(	(	PUNCT
admet-579	161	60	v	v	NOUN
admet-579	161	61	):	):	PUNCT
admet-579	161	62	/	/	SYM
admet-579	161	63	(	(	PUNCT
admet-579	161	64	/	/	SYM
admet-579	161	65	)	)	PUNCT
admet-579	161	66	(	(	PUNCT
admet-579	161	67	)	)	PUNCT
admet-579	161	68	(	(	PUNCT
admet-579	161	69	/	/	SYM
admet-579	161	70	)	)	PUNCT
admet-579	161	71	e	e	NOUN
admet-579	161	72	(	(	PUNCT
admet-579	161	73	/	/	SYM
admet-579	161	74	)	)	PUNCT
admet-579	161	75	e	e	NOUN
admet-579	161	76	/	/	SYM
admet-579	161	77			NUM
admet-579	161	78			NUM
admet-579	161	79	clt	clt	PROPN
admet-579	161	80	tcl	tcl	NOUN
admet-579	161	81	v	v	ADP
admet-579	161	82	t	t	PROPN
admet-579	161	83	clc	clc	PROPN
admet-579	162	1	t	t	PROPN
admet-579	162	2	d	d	X
admet-579	162	3	v	v	PROPN
admet-579	162	4	d	d	X
admet-579	162	5	v	v	ADP
admet-579	162	6	t	t	NOUN
admet-579	162	7	v	v	NOUN
admet-579	162	8	cl	cl	NOUN
admet-579	162	9	(	(	PUNCT
admet-579	162	10	7	7	NUM
admet-579	162	11	)	)	PUNCT
admet-579	162	12	where	where	SCONJ
admet-579	162	13	d	d	NOUN
admet-579	162	14	is	be	AUX
admet-579	162	15	the	the	DET
admet-579	162	16	dose	dose	NOUN
admet-579	162	17	and	and	CCONJ
admet-579	162	18	tcl	tcl	NOUN
admet-579	162	19	is	be	AUX
admet-579	162	20	the	the	DET
admet-579	162	21	metabolic	metabolic	NOUN
admet-579	162	22	(	(	PUNCT
admet-579	162	23	ie	ie	X
admet-579	162	24	,	,	PUNCT
admet-579	162	25	liver	liver	NOUN
admet-579	162	26	)	)	PUNCT
admet-579	162	27	time	time	NOUN
admet-579	162	28	constant	constant	ADJ
admet-579	162	29	.	.	PUNCT
admet-579	163	1	although	although	SCONJ
admet-579	163	2	the	the	DET
admet-579	163	3	detailed	detailed	ADJ
admet-579	163	4	pbpk	pbpk	NOUN
admet-579	163	5	model	model	NOUN
admet-579	163	6	is	be	AUX
admet-579	163	7	required	require	VERB
admet-579	163	8	to	to	PART
admet-579	163	9	describe	describe	VERB
admet-579	163	10	the	the	DET
admet-579	163	11	short	short	ADJ
admet-579	163	12	time	time	NOUN
admet-579	163	13	pk	pk	NOUN
admet-579	163	14	of	of	ADP
admet-579	163	15	the	the	DET
admet-579	163	16	pops	pop	NOUN
admet-579	163	17	,	,	PUNCT
admet-579	163	18	at	at	ADP
admet-579	163	19	long	long	ADJ
admet-579	163	20	times	time	NOUN
admet-579	163	21	the	the	DET
admet-579	163	22	pk	pk	NOUN
admet-579	163	23	depends	depend	VERB
admet-579	163	24	only	only	ADV
admet-579	163	25	on	on	ADP
admet-579	163	26	the	the	DET
admet-579	163	27	liver	liver	NOUN
admet-579	163	28	clearance	clearance	NOUN
admet-579	163	29	and	and	CCONJ
admet-579	163	30	is	be	AUX
admet-579	163	31	independent	independent	ADJ
admet-579	163	32	of	of	ADP
admet-579	163	33	the	the	DET
admet-579	163	34	kinetics	kinetic	NOUN
admet-579	163	35	of	of	ADP
admet-579	163	36	solute	solute	ADJ
admet-579	163	37	exchange	exchange	NOUN
admet-579	163	38	in	in	ADP
admet-579	163	39	the	the	DET
admet-579	163	40	peripheral	peripheral	ADJ
admet-579	163	41	tissues	tissue	NOUN
admet-579	163	42	.	.	PUNCT
admet-579	164	1	this	this	PRON
admet-579	164	2	is	be	AUX
admet-579	164	3	quantitatively	quantitatively	ADV
admet-579	164	4	illustrated	illustrate	VERB
admet-579	164	5	using	use	VERB
admet-579	164	6	the	the	DET
admet-579	164	7	pbpk	pbpk	PROPN
admet-579	164	8	cannabinol	cannabinol	PROPN
admet-579	164	9	model	model	NOUN
admet-579	164	10	described	describe	VERB
admet-579	164	11	above	above	ADP
admet-579	164	12	[	[	X
admet-579	164	13	12	12	NUM
admet-579	164	14	]	]	PUNCT
admet-579	164	15	.	.	PUNCT
admet-579	165	1	figure	figure	NOUN
admet-579	165	2	9	9	NUM
admet-579	165	3	shows	show	VERB
admet-579	165	4	a	a	DET
admet-579	165	5	comparison	comparison	NOUN
admet-579	165	6	of	of	ADP
admet-579	165	7	the	the	DET
admet-579	165	8	plasma	plasma	NOUN
admet-579	165	9	cannabinol	cannabinol	NOUN
admet-579	165	10	concentration	concentration	NOUN
admet-579	165	11	for	for	ADP
admet-579	165	12	the	the	DET
admet-579	165	13	pbpk	pbpk	NOUN
admet-579	165	14	(	(	PUNCT
admet-579	165	15	black	black	ADJ
admet-579	165	16	line	line	NOUN
admet-579	165	17	)	)	PUNCT
admet-579	165	18	versus	versus	ADP
admet-579	165	19	the	the	DET
admet-579	165	20	1	1	NUM
admet-579	165	21	-	-	PUNCT
admet-579	165	22	compartment	compartment	NOUN
admet-579	165	23	model	model	NOUN
admet-579	165	24	(	(	PUNCT
admet-579	165	25	red	red	ADJ
admet-579	165	26	line	line	NOUN
admet-579	165	27	)	)	PUNCT
admet-579	165	28	as	as	ADP
admet-579	165	29	the	the	DET
admet-579	165	30	metabolic	metabolic	NOUN
admet-579	165	31	time	time	NOUN
admet-579	165	32	constant	constant	ADJ
admet-579	165	33	(	(	PUNCT
admet-579	165	34	tcl	tcl	NOUN
admet-579	165	35	)	)	PUNCT
admet-579	165	36	increases	increase	NOUN
admet-579	165	37	from	from	ADP
admet-579	165	38	1.25	1.25	NUM
admet-579	165	39	days	day	NOUN
admet-579	165	40	(	(	PUNCT
admet-579	165	41	top	top	ADJ
admet-579	165	42	panel	panel	NOUN
admet-579	165	43	)	)	PUNCT
admet-579	165	44	to	to	ADP
admet-579	165	45	125	125	NUM
admet-579	165	46	days	day	NOUN
admet-579	165	47	(	(	PUNCT
admet-579	165	48	bottom	bottom	ADJ
admet-579	165	49	panel	panel	NOUN
admet-579	165	50	)	)	PUNCT
admet-579	165	51	.	.	PUNCT
admet-579	166	1	it	it	PRON
admet-579	166	2	can	can	AUX
admet-579	166	3	be	be	AUX
admet-579	166	4	seen	see	VERB
admet-579	166	5	(	(	PUNCT
admet-579	166	6	bottom	bottom	ADJ
admet-579	166	7	panel	panel	NOUN
admet-579	166	8	)	)	PUNCT
admet-579	167	1	that	that	SCONJ
admet-579	167	2	when	when	SCONJ
admet-579	167	3	the	the	DET
admet-579	167	4	metabolic	metabolic	NOUN
admet-579	167	5	excretion	excretion	NOUN
admet-579	167	6	rate	rate	NOUN
admet-579	167	7	becomes	become	VERB
admet-579	167	8	rate	rate	NOUN
admet-579	167	9	limiting	limiting	NOUN
admet-579	167	10	(	(	PUNCT
admet-579	167	11	tcl	tcl	NOUN
admet-579	167	12	=	=	SYM
admet-579	167	13	125	125	NUM
admet-579	167	14	days	day	NOUN
admet-579	167	15	>	>	PUNCT
admet-579	167	16	>	>	X
admet-579	167	17	tadipose	tadipose	PRON
admet-579	167	18	=	=	ADJ
admet-579	167	19	11	11	NUM
admet-579	167	20	days	day	NOUN
admet-579	167	21	)	)	PUNCT
admet-579	167	22	,	,	PUNCT
admet-579	167	23	the	the	DET
admet-579	167	24	one	one	NUM
admet-579	167	25	compartment	compartment	NOUN
admet-579	167	26	model	model	NOUN
admet-579	167	27	provides	provide	VERB
admet-579	167	28	a	a	DET
admet-579	167	29	good	good	ADJ
admet-579	167	30	prediction	prediction	NOUN
admet-579	167	31	of	of	ADP
admet-579	167	32	the	the	DET
admet-579	167	33	pk	pk	NOUN
admet-579	167	34	after	after	ADP
admet-579	167	35	the	the	DET
admet-579	167	36	initial	initial	ADJ
admet-579	167	37	≈11	≈11	NOUN
admet-579	167	38	day	day	NOUN
admet-579	167	39	transient	transient	ADJ
admet-579	167	40	period	period	NOUN
admet-579	167	41	when	when	SCONJ
admet-579	167	42	the	the	DET
admet-579	167	43	adipose	adipose	ADJ
admet-579	167	44	tissue	tissue	NOUN
admet-579	167	45	exchange	exchange	NOUN
admet-579	167	46	is	be	AUX
admet-579	167	47	limiting	limit	VERB
admet-579	167	48	.	.	PUNCT
admet-579	168	1	extracellular	extracellular	ADJ
admet-579	168	2	solutes	solute	NOUN
admet-579	168	3	(	(	PUNCT
admet-579	168	4	ecs	ec	NOUN
admet-579	168	5	)	)	PUNCT
admet-579	168	6	because	because	SCONJ
admet-579	168	7	the	the	DET
admet-579	168	8	ecs	ec	NOUN
admet-579	168	9	,	,	PUNCT
admet-579	168	10	by	by	ADP
admet-579	168	11	definition	definition	NOUN
admet-579	168	12	,	,	PUNCT
admet-579	168	13	do	do	AUX
admet-579	168	14	not	not	PART
admet-579	168	15	enter	enter	VERB
admet-579	168	16	cells	cell	NOUN
admet-579	168	17	,	,	PUNCT
admet-579	168	18	they	they	PRON
admet-579	168	19	are	be	AUX
admet-579	168	20	not	not	PART
admet-579	168	21	subject	subject	ADJ
admet-579	168	22	to	to	ADP
admet-579	168	23	the	the	DET
admet-579	168	24	poorly	poorly	ADV
admet-579	168	25	characterized	characterize	VERB
admet-579	168	26	intracellular	intracellular	ADJ
admet-579	168	27	binding	binding	NOUN
admet-579	168	28	that	that	PRON
admet-579	168	29	confounds	confound	VERB
admet-579	168	30	predictions	prediction	NOUN
admet-579	168	31	of	of	ADP
admet-579	168	32	the	the	DET
admet-579	168	33	k	k	PROPN
admet-579	168	34	i	i	PRON
admet-579	168	35	for	for	ADP
admet-579	168	36	the	the	DET
admet-579	168	37	typical	typical	ADJ
admet-579	168	38	weak	weak	ADJ
admet-579	168	39	acid	acid	NOUN
admet-579	168	40	or	or	CCONJ
admet-579	168	41	base	base	NOUN
admet-579	168	42	.	.	PUNCT
admet-579	169	1	since	since	SCONJ
admet-579	169	2	the	the	DET
admet-579	169	3	ecs	ecs	PROPN
admet-579	169	4	solutes	solute	NOUN
admet-579	169	5	are	be	AUX
admet-579	169	6	confined	confine	VERB
admet-579	169	7	to	to	ADP
admet-579	169	8	the	the	DET
admet-579	169	9	plasma	plasma	NOUN
admet-579	169	10	and	and	CCONJ
admet-579	169	11	interstitial	interstitial	ADJ
admet-579	169	12	space	space	NOUN
admet-579	169	13	,	,	PUNCT
admet-579	169	14	the	the	DET
admet-579	169	15	basic	basic	ADJ
admet-579	169	16	pbpk	pbpk	ADJ
admet-579	169	17	equations	equation	NOUN
admet-579	169	18	described	describe	VERB
admet-579	169	19	above	above	ADV
admet-579	169	20	(	(	PUNCT
admet-579	169	21	eqs	eqs	X
admet-579	169	22	.	.	PUNCT
admet-579	170	1	(	(	PUNCT
admet-579	170	2	1	1	X
admet-579	170	3	)	)	PUNCT
admet-579	170	4	and	and	CCONJ
admet-579	170	5	(	(	PUNCT
admet-579	170	6	2	2	NUM
admet-579	170	7	)	)	PUNCT
admet-579	170	8	)	)	PUNCT
admet-579	170	9	are	be	AUX
admet-579	170	10	modified	modify	VERB
admet-579	170	11	as	as	SCONJ
admet-579	170	12	follows	follow	VERB
admet-579	170	13	:	:	PUNCT
admet-579	171	1	i	i	PRON
admet-579	171	2	i	i	PRON
admet-579	172	1	i	i	PRON
admet-579	172	2	a	a	DET
admet-579	172	3	ip	ip	NOUN
admet-579	172	4	ec	ec	PROPN
admet-579	173	1	p	p	NOUN
admet-579	173	2	p	p	X
admet-579	174	1	p	p	X
admet-579	174	2	i	i	PRON
admet-579	175	1	i	i	PRON
admet-579	175	2	i	i	PRON
admet-579	176	1	i	i	PRON
admet-579	176	2	ec	ec	PROPN
admet-579	177	1	p	p	PROPN
admet-579	177	2	ec	ec	PROPN
admet-579	177	3	ect	ect	X
admet-579	177	4	d	d	PROPN
admet-579	177	5	(	(	PUNCT
admet-579	177	6	)	)	PUNCT
admet-579	178	1	[	[	X
admet-579	178	2	c	c	X
admet-579	178	3	(	(	PUNCT
admet-579	178	4	)	)	PUNCT
admet-579	178	5	(	(	PUNCT
admet-579	178	6	)	)	PUNCT
admet-579	178	7	]	]	PUNCT
admet-579	178	8	c	c	X
admet-579	178	9	t	t	PROPN
admet-579	178	10	v	v	X
admet-579	178	11	f	f	PROPN
admet-579	179	1	t	t	PROPN
admet-579	179	2	c	c	PROPN
admet-579	179	3	t	t	PROPN
admet-579	179	4	dt	dt	X
admet-579	179	5	v	v	ADP
admet-579	179	6	v	v	INTJ
admet-579	179	7	k	k	PROPN
admet-579	179	8	v	v	PROPN
admet-579	179	9			PROPN
admet-579	179	10			PROPN
admet-579	179	11			PRON
admet-579	179	12			PRON
admet-579	179	13	(	(	PUNCT
admet-579	179	14	8)	8)	NUM
admet-579	179	15	where	where	SCONJ
admet-579	179	16	fp	fp	INTJ
admet-579	179	17	i	i	PRON
admet-579	179	18	is	be	AUX
admet-579	179	19	the	the	DET
admet-579	179	20	organ	organ	NOUN
admet-579	179	21	plasma	plasma	NOUN
admet-579	179	22	flow	flow	NOUN
admet-579	179	23	,	,	PUNCT
admet-579	179	24	cp	cp	PROPN
admet-579	179	25	a	a	PRON
admet-579	179	26	is	be	AUX
admet-579	179	27	the	the	DET
admet-579	179	28	plasma	plasma	NOUN
admet-579	179	29	arterial	arterial	NOUN
admet-579	179	30	concentration	concentration	NOUN
admet-579	179	31	,	,	PUNCT
admet-579	179	32	and	and	CCONJ
admet-579	179	33	cp	cp	INTJ
admet-579	179	34	i	i	PRON
admet-579	179	35	is	be	AUX
admet-579	179	36	the	the	DET
admet-579	179	37	venous	venous	ADJ
admet-579	179	38	plasma	plasma	NOUN
admet-579	179	39	concentration	concentration	NOUN
admet-579	179	40	.	.	PUNCT
admet-579	180	1	the	the	DET
admet-579	180	2	ecs	ecs	PROPN
admet-579	180	3	volume	volume	NOUN
admet-579	180	4	of	of	ADP
admet-579	180	5	distribution	distribution	NOUN
admet-579	180	6	(	(	PUNCT
admet-579	180	7	vec	vec	PROPN
admet-579	180	8	i	i	PROPN
admet-579	180	9	)	)	PUNCT
admet-579	180	10	is	be	AUX
admet-579	180	11	defined	define	VERB
admet-579	180	12	in	in	ADP
admet-579	180	13	terms	term	NOUN
admet-579	180	14	of	of	ADP
admet-579	180	15	the	the	DET
admet-579	180	16	anatomical	anatomical	ADJ
admet-579	180	17	plasma	plasma	NOUN
admet-579	180	18	(	(	PUNCT
admet-579	180	19	vp	vp	NOUN
admet-579	180	20	i	i	PROPN
admet-579	180	21	)	)	PUNCT
admet-579	180	22	and	and	CCONJ
admet-579	180	23	interstitial	interstitial	ADJ
admet-579	180	24	(	(	PUNCT
admet-579	180	25	vect	vect	NOUN
admet-579	180	26	i	i	NOUN
admet-579	180	27	)	)	PUNCT
admet-579	180	28	volumes	volume	NOUN
admet-579	180	29	and	and	CCONJ
admet-579	180	30	the	the	DET
admet-579	180	31	ecs	ecs	PROPN
admet-579	180	32	interstitial	interstitial	ADJ
admet-579	180	33	/	/	SYM
admet-579	180	34	plasma	plasma	NOUN
admet-579	180	35	partition	partition	NOUN
admet-579	180	36	coefficient	coefficient	NOUN
admet-579	180	37	(	(	PUNCT
admet-579	180	38	kec	kec	PROPN
admet-579	180	39	i	i	PROPN
admet-579	180	40	)	)	PUNCT
admet-579	180	41	.	.	PUNCT
admet-579	181	1	because	because	SCONJ
admet-579	181	2	both	both	CCONJ
admet-579	181	3	the	the	DET
admet-579	181	4	plasma	plasma	NOUN
admet-579	181	5	and	and	CCONJ
admet-579	181	6	interstitial	interstitial	ADJ
admet-579	181	7	ecs	ec	NOUN
admet-579	181	8	binding	binding	NOUN
admet-579	181	9	is	be	AUX
admet-579	181	10	dominated	dominate	VERB
admet-579	181	11	by	by	ADP
admet-579	181	12	the	the	DET
admet-579	181	13	plasma	plasma	NOUN
admet-579	181	14	and	and	CCONJ
admet-579	181	15	interstitial	interstitial	ADJ
admet-579	181	16	albumin	albumin	NOUN
admet-579	181	17	,	,	PUNCT
admet-579	181	18	it	it	PRON
admet-579	181	19	can	can	AUX
admet-579	181	20	be	be	AUX
admet-579	181	21	shown	show	VERB
admet-579	181	22	[	[	PUNCT
admet-579	181	23	7	7	X
admet-579	181	24	]	]	PUNCT
admet-579	181	25	that	that	SCONJ
admet-579	181	26	the	the	DET
admet-579	181	27	ecs	ecs	PROPN
admet-579	181	28	partition	partition	PROPN
admet-579	181	29	coefficient	coefficient	NOUN
admet-579	181	30	(	(	PUNCT
admet-579	181	31	kec	kec	PROPN
admet-579	181	32	i	i	PROPN
admet-579	181	33	)	)	PUNCT
admet-579	181	34	can	can	AUX
admet-579	181	35	be	be	AUX
admet-579	181	36	described	describe	VERB
admet-579	181	37	by	by	ADP
admet-579	181	38	:	:	PUNCT
admet-579	181	39	i	i	PRON
admet-579	181	40	i	i	PRON
admet-579	182	1	i	i	PRON
admet-579	182	2	ec	ec	PROPN
admet-579	182	3	alb	alb	PROPN
admet-579	182	4	p	p	PROPN
admet-579	182	5	alb(1	alb(1	PROPN
admet-579	182	6	)	)	PUNCT
admet-579	183	1	k	k	PROPN
admet-579	184	1	k	k	PROPN
admet-579	184	2	f	f	PROPN
admet-579	184	3	k	k	PROPN
admet-579	184	4			PROPN
admet-579	184	5			X
admet-579	184	6	(	(	PUNCT
admet-579	184	7	9	9	NUM
admet-579	184	8	)	)	PUNCT
admet-579	184	9	where	where	SCONJ
admet-579	184	10	kalb	kalb	PROPN
admet-579	184	11	i	i	PROPN
admet-579	184	12	is	be	AUX
admet-579	184	13	ratio	ratio	NOUN
admet-579	184	14	of	of	ADP
admet-579	184	15	interstitial	interstitial	ADJ
admet-579	184	16	/	/	SYM
admet-579	184	17	plasma	plasma	NOUN
admet-579	184	18	albumin	albumin	ADJ
admet-579	184	19	concentration	concentration	NOUN
admet-579	184	20	in	in	ADP
admet-579	184	21	organ	organ	NOUN
admet-579	184	22	i	i	PRON
admet-579	184	23	and	and	CCONJ
admet-579	184	24	fp	fp	PROPN
admet-579	184	25	is	be	AUX
admet-579	184	26	the	the	DET
admet-579	184	27	fraction	fraction	NOUN
admet-579	184	28	of	of	ADP
admet-579	184	29	the	the	DET
admet-579	184	30	ecs	ecs	PROPN
admet-579	184	31	solute	solute	NOUN
admet-579	184	32	that	that	PRON
admet-579	184	33	is	be	AUX
admet-579	184	34	free	free	ADJ
admet-579	184	35	(	(	PUNCT
admet-579	184	36	unbound	unbound	NOUN
admet-579	184	37	)	)	PUNCT
admet-579	184	38	in	in	ADP
admet-579	184	39	plasma	plasma	NOUN
admet-579	184	40	and	and	CCONJ
admet-579	184	41	characterizes	characterize	VERB
admet-579	184	42	the	the	DET
admet-579	184	43	ecs	ecs	NOUN
admet-579	184	44	albumin	albumin	ADJ
admet-579	184	45	binding	bind	VERB
admet-579	184	46	affinity	affinity	NOUN
admet-579	184	47	.	.	PUNCT
admet-579	185	1	if	if	SCONJ
admet-579	185	2	fp	fp	PROPN
admet-579	185	3	=	=	SYM
admet-579	185	4	1	1	NUM
admet-579	185	5	(	(	PUNCT
admet-579	185	6	no	no	DET
admet-579	185	7	albumin	albumin	ADJ
admet-579	185	8	binding	binding	NOUN
admet-579	185	9	)	)	PUNCT
admet-579	185	10	,	,	PUNCT
admet-579	185	11	kec	kec	PROPN
admet-579	185	12	i	i	NOUN
admet-579	185	13	=	=	NOUN
admet-579	186	1	1	1	X
admet-579	186	2	.	.	PUNCT
admet-579	187	1	if	if	SCONJ
admet-579	187	2	fp	fp	PROPN
admet-579	187	3	=	=	SYM
admet-579	187	4	0	0	PUNCT
admet-579	187	5	(	(	PUNCT
admet-579	187	6	very	very	ADV
admet-579	187	7	high	high	ADJ
admet-579	187	8	affinity	affinity	NOUN
admet-579	187	9	binding	bind	VERB
admet-579	187	10	)	)	PUNCT
admet-579	187	11	,	,	PUNCT
admet-579	187	12	kec	kec	PROPN
admet-579	187	13	i	i	PRON
admet-579	187	14	=	=	PROPN
admet-579	187	15	kalb	kalb	PROPN
admet-579	187	16	i.	i.	PROPN
admet-579	187	17	levitt	levitt	PROPN
admet-579	188	1	[	[	X
admet-579	188	2	7	7	X
admet-579	188	3	]	]	PUNCT
admet-579	188	4	has	have	AUX
admet-579	188	5	carried	carry	VERB
admet-579	188	6	out	out	ADP
admet-579	188	7	a	a	DET
admet-579	188	8	detailed	detailed	ADJ
admet-579	188	9	review	review	NOUN
admet-579	188	10	of	of	ADP
admet-579	188	11	the	the	DET
admet-579	188	12	literature	literature	NOUN
admet-579	188	13	and	and	CCONJ
admet-579	188	14	determined	determine	VERB
admet-579	188	15	an	an	DET
admet-579	188	16	optimal	optimal	ADJ
admet-579	188	17	set	set	NOUN
admet-579	188	18	of	of	ADP
admet-579	188	19	values	value	NOUN
admet-579	188	20	for	for	ADP
admet-579	188	21	kalb	kalb	PROPN
admet-579	188	22	i	i	PRON
admet-579	188	23	(	(	PUNCT
admet-579	188	24	the	the	DET
admet-579	188	25	ratio	ratio	NOUN
admet-579	188	26	of	of	ADP
admet-579	188	27	interstitial	interstitial	ADJ
admet-579	188	28	/	/	SYM
admet-579	188	29	plasma	plasma	NOUN
admet-579	188	30	albumin	albumin	ADJ
admet-579	188	31	concentration	concentration	NOUN
admet-579	188	32	)	)	PUNCT
admet-579	188	33	and	and	CCONJ
admet-579	188	34	the	the	DET
admet-579	188	35	fraction	fraction	NOUN
admet-579	188	36	of	of	ADP
admet-579	188	37	each	each	DET
admet-579	188	38	organ	organ	NOUN
admet-579	188	39	that	that	PRON
admet-579	188	40	is	be	AUX
admet-579	188	41	david	david	PROPN
admet-579	188	42	levitt	levitt	PROPN
admet-579	188	43	admet	admet	PROPN
admet-579	188	44	&	&	CCONJ
admet-579	188	45	dmpk	dmpk	PROPN
admet-579	188	46	7(1	7(1	PROPN
admet-579	188	47	)	)	PUNCT
admet-579	188	48	(	(	PUNCT
admet-579	188	49	2019)60	2019)60	NUM
admet-579	188	50	-	-	SYM
admet-579	188	51	75	75	NUM
admet-579	188	52	70	70	NUM
admet-579	188	53	extracellular	extracellular	ADJ
admet-579	188	54	(	(	PUNCT
admet-579	188	55	ecf	ecf	PROPN
admet-579	188	56	fraction	fraction	PROPN
admet-579	188	57	)	)	PUNCT
admet-579	188	58	with	with	ADP
admet-579	188	59	vect	vect	NOUN
admet-579	188	60	i	i	PRON
admet-579	188	61	(	(	PUNCT
admet-579	188	62	the	the	DET
admet-579	188	63	anatomic	anatomic	ADJ
admet-579	188	64	interstitial	interstitial	ADJ
admet-579	188	65	volume	volume	NOUN
admet-579	188	66	for	for	ADP
admet-579	188	67	each	each	DET
admet-579	188	68	organ	organ	NOUN
admet-579	188	69	i	i	NOUN
admet-579	188	70	)	)	PUNCT
admet-579	188	71	equal	equal	ADJ
admet-579	188	72	to	to	ADP
admet-579	188	73	the	the	DET
admet-579	188	74	ecf	ecf	PROPN
admet-579	188	75	fraction	fraction	PROPN
admet-579	188	76	times	time	NOUN
admet-579	188	77	the	the	DET
admet-579	188	78	total	total	ADJ
admet-579	188	79	organ	organ	NOUN
admet-579	188	80	volume	volume	NOUN
admet-579	188	81	.	.	PUNCT
admet-579	189	1	these	these	DET
admet-579	189	2	parameters	parameter	NOUN
admet-579	189	3	are	be	AUX
admet-579	189	4	listed	list	VERB
admet-579	189	5	in	in	ADP
admet-579	189	6	table	table	NOUN
admet-579	189	7	1	1	NUM
admet-579	189	8	and	and	CCONJ
admet-579	189	9	are	be	AUX
admet-579	189	10	the	the	DET
admet-579	189	11	default	default	NOUN
admet-579	189	12	parameters	parameter	NOUN
admet-579	189	13	in	in	ADP
admet-579	189	14	pkquest	pkqu	ADJ
admet-579	189	15	.	.	PUNCT
admet-579	190	1	using	use	VERB
admet-579	190	2	these	these	DET
admet-579	190	3	predetermined	predetermine	VERB
admet-579	190	4	values	value	NOUN
admet-579	190	5	,	,	PUNCT
admet-579	190	6	the	the	DET
admet-579	190	7	only	only	ADJ
admet-579	190	8	parameter	parameter	NOUN
admet-579	190	9	that	that	PRON
admet-579	190	10	is	be	AUX
admet-579	190	11	solute	solute	VERB
admet-579	190	12	specific	specific	ADJ
admet-579	190	13	is	be	AUX
admet-579	190	14	fp	fp	INTJ
admet-579	190	15	(	(	PUNCT
admet-579	190	16	the	the	DET
admet-579	190	17	free	free	ADJ
admet-579	190	18	solute	solute	NOUN
admet-579	190	19	fraction	fraction	NOUN
admet-579	190	20	in	in	ADP
admet-579	190	21	plasma	plasma	NOUN
admet-579	190	22	)	)	PUNCT
admet-579	190	23	and	and	CCONJ
admet-579	190	24	this	this	PRON
admet-579	190	25	can	can	AUX
admet-579	190	26	be	be	AUX
admet-579	190	27	determined	determine	VERB
admet-579	190	28	from	from	ADP
admet-579	190	29	in	in	ADP
admet-579	190	30	vitro	vitro	X
admet-579	190	31	measurements	measurement	NOUN
admet-579	190	32	.	.	PUNCT
admet-579	191	1	thus	thus	ADV
admet-579	191	2	,	,	PUNCT
admet-579	191	3	all	all	PRON
admet-579	191	4	of	of	ADP
admet-579	191	5	the	the	DET
admet-579	191	6	parameters	parameter	NOUN
admet-579	191	7	in	in	ADP
admet-579	191	8	eqs	eqs	PROPN
admet-579	191	9	.	.	PUNCT
admet-579	192	1	(	(	PUNCT
admet-579	192	2	8)	8)	NUM
admet-579	192	3	and	and	CCONJ
admet-579	192	4	(	(	PUNCT
admet-579	192	5	9	9	NUM
admet-579	192	6	)	)	PUNCT
admet-579	192	7	can	can	AUX
admet-579	192	8	be	be	AUX
admet-579	192	9	determined	determine	VERB
admet-579	192	10	a	a	DET
admet-579	192	11	priori	priori	ADV
admet-579	192	12	,	,	PUNCT
admet-579	192	13	providing	provide	VERB
admet-579	192	14	a	a	DET
admet-579	192	15	complete	complete	ADJ
admet-579	192	16	description	description	NOUN
admet-579	192	17	of	of	ADP
admet-579	192	18	the	the	DET
admet-579	192	19	ecs	ecs	PROPN
admet-579	192	20	pbpk	pbpk	PROPN
admet-579	192	21	.	.	PROPN
admet-579	192	22	figure	figure	NOUN
admet-579	192	23	9	9	NUM
admet-579	192	24	.	.	PUNCT
admet-579	193	1	comparison	comparison	NOUN
admet-579	193	2	of	of	ADP
admet-579	193	3	1	1	NUM
admet-579	193	4	-	-	PUNCT
admet-579	193	5	compartment	compartment	NOUN
admet-579	193	6	(	(	PUNCT
admet-579	193	7	red	red	NOUN
admet-579	193	8	)	)	PUNCT
admet-579	193	9	vs	vs	ADP
admet-579	193	10	pbpk	pbpk	NOUN
admet-579	193	11	(	(	PUNCT
admet-579	193	12	black	black	ADJ
admet-579	193	13	)	)	PUNCT
admet-579	193	14	model	model	NOUN
admet-579	193	15	for	for	ADP
admet-579	193	16	hls	hls	PROPN
admet-579	193	17	(	(	PUNCT
admet-579	193	18	eg	eg	NOUN
admet-579	193	19	,	,	PUNCT
admet-579	193	20	cannabinol	cannabinol	NOUN
admet-579	193	21	)	)	PUNCT
admet-579	193	22	with	with	ADP
admet-579	193	23	an	an	DET
admet-579	193	24	adipose	adipose	ADJ
admet-579	193	25	time	time	NOUN
admet-579	193	26	constant	constant	ADJ
admet-579	193	27	of	of	ADP
admet-579	193	28	about	about	ADV
admet-579	193	29	11	11	NUM
admet-579	193	30	days	day	NOUN
admet-579	193	31	.	.	PUNCT
admet-579	194	1	as	as	SCONJ
admet-579	194	2	the	the	DET
admet-579	194	3	metabolic	metabolic	NOUN
admet-579	194	4	time	time	NOUN
admet-579	194	5	constant	constant	ADJ
admet-579	194	6	(	(	PUNCT
admet-579	194	7	ie	ie	X
admet-579	194	8	,	,	PUNCT
admet-579	194	9	liver	liver	NOUN
admet-579	194	10	clearance	clearance	NOUN
admet-579	194	11	)	)	PUNCT
admet-579	194	12	increases	increase	NOUN
admet-579	194	13	from	from	ADP
admet-579	194	14	1.25	1.25	NUM
admet-579	194	15	days	day	NOUN
admet-579	194	16	(	(	PUNCT
admet-579	194	17	top	top	NOUN
admet-579	194	18	)	)	PUNCT
admet-579	194	19	,	,	PUNCT
admet-579	194	20	to	to	ADP
admet-579	194	21	12.5	12.5	NUM
admet-579	194	22	(	(	PUNCT
admet-579	194	23	middle	middle	NOUN
admet-579	194	24	)	)	PUNCT
admet-579	194	25	to	to	ADP
admet-579	194	26	125	125	NUM
admet-579	194	27	days	day	NOUN
admet-579	194	28	(	(	PUNCT
admet-579	194	29	bottom	bottom	NOUN
admet-579	194	30	)	)	PUNCT
admet-579	194	31	,	,	PUNCT
admet-579	194	32	the	the	DET
admet-579	194	33	pbpk	pbpk	PROPN
admet-579	194	34	model	model	NOUN
admet-579	194	35	approaches	approach	VERB
admet-579	194	36	the	the	DET
admet-579	194	37	1	1	NUM
admet-579	194	38	-	-	PUNCT
admet-579	194	39	compartment	compartment	NOUN
admet-579	194	40	model	model	NOUN
admet-579	194	41	at	at	ADP
admet-579	194	42	times	time	NOUN
admet-579	194	43	longer	long	ADJ
admet-579	194	44	than	than	ADP
admet-579	194	45	11	11	NUM
admet-579	194	46	days	day	NOUN
admet-579	194	47	.	.	PUNCT
admet-579	195	1	for	for	ADP
admet-579	195	2	most	most	ADJ
admet-579	195	3	ecs	ec	NOUN
admet-579	195	4	,	,	PUNCT
admet-579	195	5	there	there	PRON
admet-579	195	6	is	be	VERB
admet-579	195	7	only	only	ADV
admet-579	195	8	one	one	NUM
admet-579	195	9	adjustable	adjustable	ADJ
admet-579	195	10	parameter	parameter	NOUN
admet-579	195	11	,	,	PUNCT
admet-579	195	12	the	the	DET
admet-579	195	13	clearance	clearance	NOUN
admet-579	195	14	(	(	PUNCT
admet-579	195	15	usually	usually	ADV
admet-579	195	16	renal	renal	ADJ
admet-579	195	17	)	)	PUNCT
admet-579	195	18	.	.	PUNCT
admet-579	196	1	figure	figure	NOUN
admet-579	196	2	10	10	NUM
admet-579	196	3	shows	show	VERB
admet-579	196	4	the	the	DET
admet-579	196	5	top	top	ADJ
admet-579	196	6	panel	panel	NOUN
admet-579	196	7	of	of	ADP
admet-579	196	8	the	the	DET
admet-579	196	9	pkquest	pkqu	ADJ
admet-579	196	10	interface	interface	NOUN
admet-579	196	11	for	for	ADP
admet-579	196	12	amoxicillin	amoxicillin	NOUN
admet-579	196	13	.	.	PUNCT
admet-579	197	1	the	the	DET
admet-579	197	2	“	"	PUNCT
admet-579	197	3	extracellular	extracellular	ADJ
admet-579	197	4	”	"	PUNCT
admet-579	197	5	check	check	NOUN
admet-579	197	6	box	box	NOUN
admet-579	197	7	turns	turn	VERB
admet-579	197	8	on	on	ADP
admet-579	197	9	the	the	DET
admet-579	197	10	ecs	ecs	PROPN
admet-579	197	11	pbpk	pbpk	PROPN
admet-579	197	12	model	model	NOUN
admet-579	197	13	.	.	PUNCT
admet-579	198	1	the	the	DET
admet-579	198	2	“	"	PUNCT
admet-579	198	3	freepl	freepl	NOUN
admet-579	198	4	”	"	PUNCT
admet-579	198	5	is	be	AUX
admet-579	198	6	the	the	DET
admet-579	198	7	fraction	fraction	NOUN
admet-579	198	8	free	free	ADJ
admet-579	198	9	in	in	ADP
admet-579	198	10	plasma	plasma	NOUN
admet-579	198	11	(=	(=	NOUN
admet-579	198	12	fp	fp	NOUN
admet-579	198	13	)	)	PUNCT
admet-579	198	14	,	,	PUNCT
admet-579	198	15	which	which	PRON
admet-579	198	16	characterizes	characterize	VERB
admet-579	198	17	both	both	CCONJ
admet-579	198	18	the	the	DET
admet-579	198	19	plasma	plasma	NOUN
admet-579	198	20	and	and	CCONJ
admet-579	198	21	interstitial	interstitial	ADJ
admet-579	198	22	albumin	albumin	ADJ
admet-579	198	23	binding	binding	NOUN
admet-579	198	24	.	.	PUNCT
admet-579	199	1	the	the	DET
admet-579	199	2	only	only	ADJ
admet-579	199	3	adjustable	adjustable	ADJ
admet-579	199	4	parameter	parameter	NOUN
admet-579	199	5	is	be	AUX
admet-579	199	6	the	the	DET
admet-579	199	7	“	"	PUNCT
admet-579	199	8	renal	renal	ADJ
admet-579	199	9	clr	clr	NOUN
admet-579	199	10	”	"	PUNCT
admet-579	199	11	which	which	PRON
admet-579	199	12	is	be	AUX
admet-579	199	13	set	set	VERB
admet-579	199	14	to	to	ADP
admet-579	199	15	0.353	0.353	NUM
admet-579	199	16	(	(	PUNCT
admet-579	199	17	the	the	DET
admet-579	199	18	fraction	fraction	NOUN
admet-579	199	19	of	of	ADP
admet-579	199	20	admet	admet	PROPN
admet-579	199	21	&	&	CCONJ
admet-579	199	22	dmpk	dmpk	PROPN
admet-579	199	23	7(1	7(1	PROPN
admet-579	199	24	)	)	PUNCT
admet-579	199	25	(	(	PUNCT
admet-579	199	26	2019	2019	NUM
admet-579	199	27	)	)	PUNCT
admet-579	199	28	60	60	NUM
admet-579	199	29	-	-	SYM
admet-579	199	30	75	75	NUM
admet-579	199	31	lipid	lipid	NOUN
admet-579	199	32	soluble	soluble	ADJ
admet-579	199	33	and	and	CCONJ
admet-579	199	34	extracellular	extracellular	ADJ
admet-579	199	35	solutes	solute	NOUN
admet-579	199	36	doi	doi	NOUN
admet-579	199	37	:	:	PUNCT
admet-579	199	38	10.5599	10.5599	NUM
admet-579	199	39	/	/	SYM
admet-579	199	40	admet.579	admet.579	NOUN
admet-579	199	41	71	71	NUM
admet-579	199	42	renal	renal	ADJ
admet-579	199	43	plasma	plasma	NOUN
admet-579	199	44	cleared	clear	VERB
admet-579	199	45	)	)	PUNCT
admet-579	199	46	.	.	PUNCT
admet-579	200	1	note	note	VERB
admet-579	200	2	also	also	ADV
admet-579	200	3	that	that	SCONJ
admet-579	200	4	the	the	DET
admet-579	200	5	“	"	PUNCT
admet-579	200	6	cap	cap	NOUN
admet-579	200	7	perm	perm	NOUN
admet-579	200	8	”	"	PUNCT
admet-579	200	9	is	be	AUX
admet-579	200	10	set	set	VERB
admet-579	200	11	to	to	ADP
admet-579	200	12	1.0	1.0	NUM
admet-579	200	13	,	,	PUNCT
admet-579	200	14	indicating	indicate	VERB
admet-579	200	15	infinite	infinite	ADJ
admet-579	200	16	capillary	capillary	ADJ
admet-579	200	17	permeability	permeability	NOUN
admet-579	200	18	(	(	PUNCT
admet-579	200	19	see	see	VERB
admet-579	200	20	below	below	ADV
admet-579	200	21	)	)	PUNCT
admet-579	200	22	.	.	PUNCT
admet-579	201	1	figure	figure	NOUN
admet-579	201	2	11	11	NUM
admet-579	201	3	shows	show	VERB
admet-579	201	4	the	the	DET
admet-579	201	5	good	good	ADJ
admet-579	201	6	fit	fit	NOUN
admet-579	201	7	of	of	ADP
admet-579	201	8	the	the	DET
admet-579	201	9	pkquest	pkqu	ADJ
admet-579	201	10	pbpk	pbpk	ADJ
admet-579	201	11	prediction	prediction	NOUN
admet-579	201	12	to	to	ADP
admet-579	201	13	the	the	DET
admet-579	201	14	experimental	experimental	ADJ
admet-579	201	15	data	datum	NOUN
admet-579	201	16	of	of	ADP
admet-579	201	17	arancibia	arancibia	PROPN
admet-579	201	18	et	et	PROPN
admet-579	201	19	.	.	PUNCT
admet-579	202	1	al.[20	al.[20	PROPN
admet-579	202	2	]	]	PUNCT
admet-579	202	3	following	follow	VERB
admet-579	202	4	a	a	DET
admet-579	202	5	bolus	bolus	NOUN
admet-579	202	6	iv	iv	NUM
admet-579	202	7	input	input	NOUN
admet-579	202	8	.	.	PUNCT
admet-579	203	1	for	for	ADP
admet-579	203	2	some	some	DET
admet-579	203	3	solutes	solute	NOUN
admet-579	203	4	the	the	DET
admet-579	203	5	plasma	plasma	NOUN
admet-579	203	6	albumin	albumin	NOUN
admet-579	203	7	binding	bind	VERB
admet-579	203	8	(=	(=	X
admet-579	203	9	freepl	freepl	NOUN
admet-579	203	10	)	)	PUNCT
admet-579	203	11	is	be	AUX
admet-579	203	12	poorly	poorly	ADV
admet-579	203	13	characterized	characterize	VERB
admet-579	203	14	or	or	CCONJ
admet-579	203	15	variable	variable	ADJ
admet-579	203	16	,	,	PUNCT
admet-579	203	17	and	and	CCONJ
admet-579	203	18	one	one	NUM
admet-579	203	19	treats	treat	NOUN
admet-579	203	20	freepl	freepl	ADV
admet-579	203	21	as	as	ADP
admet-579	203	22	another	another	DET
admet-579	203	23	adjustable	adjustable	ADJ
admet-579	203	24	model	model	NOUN
admet-579	203	25	parameter	parameter	NOUN
admet-579	203	26	.	.	PUNCT
admet-579	204	1	using	use	VERB
admet-579	204	2	this	this	DET
admet-579	204	3	identical	identical	ADJ
admet-579	204	4	pbpk	pbpk	NOUN
admet-579	204	5	model	model	NOUN
admet-579	204	6	,	,	PUNCT
admet-579	204	7	similarly	similarly	ADV
admet-579	204	8	good	good	ADJ
admet-579	204	9	fits	fit	NOUN
admet-579	204	10	were	be	AUX
admet-579	204	11	obtained	obtain	VERB
admet-579	204	12	to	to	ADP
admet-579	204	13	the	the	DET
admet-579	204	14	experimental	experimental	ADJ
admet-579	204	15	pk	pk	NOUN
admet-579	204	16	measurements	measurement	NOUN
admet-579	204	17	for	for	ADP
admet-579	204	18	the	the	DET
admet-579	204	19	ecs	ecs	PROPN
admet-579	204	20	solutes	solute	VERB
admet-579	204	21	edta	edta	NOUN
admet-579	204	22	,	,	PUNCT
admet-579	204	23	dtpa	dtpa	NOUN
admet-579	204	24	,	,	PUNCT
admet-579	204	25	morphine-6	morphine-6	NOUN
admet-579	204	26	-	-	ADJ
admet-579	204	27	glucuronide	glucuronide	ADJ
admet-579	204	28	,	,	PUNCT
admet-579	204	29	morphine-3	morphine-3	NOUN
admet-579	204	30	-	-	PUNCT
admet-579	204	31	glucuronide	glucuronide	ADJ
admet-579	204	32	,	,	PUNCT
admet-579	204	33	mannitol	mannitol	NOUN
admet-579	204	34	and	and	CCONJ
admet-579	204	35	for	for	ADP
admet-579	204	36	the	the	DET
admet-579	204	37	β	β	NOUN
admet-579	204	38	-	-	PUNCT
admet-579	204	39	lactam	lactam	NOUN
admet-579	204	40	antibiotics	antibiotic	NOUN
admet-579	204	41	amoxicillin	amoxicillin	NOUN
admet-579	204	42	,	,	PUNCT
admet-579	204	43	piperacillin	piperacillin	NOUN
admet-579	204	44	and	and	CCONJ
admet-579	204	45	cefatrizine	cefatrizine	VERB
admet-579	205	1	[	[	X
admet-579	205	2	7	7	NUM
admet-579	205	3	]	]	PUNCT
admet-579	205	4	.	.	PUNCT
admet-579	206	1	figure	figure	NOUN
admet-579	206	2	10	10	NUM
admet-579	206	3	.	.	PUNCT
admet-579	207	1	top	top	ADJ
admet-579	207	2	panel	panel	NOUN
admet-579	207	3	of	of	ADP
admet-579	207	4	pkquest	pkquest	NOUN
admet-579	207	5	interface	interface	NOUN
admet-579	207	6	showing	show	VERB
admet-579	207	7	the	the	DET
admet-579	207	8	parameters	parameter	NOUN
admet-579	207	9	that	that	PRON
admet-579	207	10	characterize	characterize	VERB
admet-579	207	11	amoxicillin	amoxicillin	NOUN
admet-579	207	12	pbpk	pbpk	NOUN
admet-579	207	13	pharmacokinetics	pharmacokinetic	NOUN
admet-579	207	14	(	(	PUNCT
admet-579	207	15	see	see	VERB
admet-579	207	16	text	text	NOUN
admet-579	207	17	for	for	ADP
admet-579	207	18	details	detail	NOUN
admet-579	207	19	)	)	PUNCT
admet-579	207	20	.	.	PUNCT
admet-579	208	1	for	for	ADP
admet-579	208	2	all	all	DET
admet-579	208	3	the	the	DET
admet-579	208	4	solutes	solute	NOUN
admet-579	208	5	discussed	discuss	VERB
admet-579	208	6	above	above	ADV
admet-579	208	7	,	,	PUNCT
admet-579	208	8	the	the	DET
admet-579	208	9	standard	standard	ADJ
admet-579	208	10	pbpk	pbpk	NOUN
admet-579	208	11	“	"	PUNCT
admet-579	208	12	flow	flow	NOUN
admet-579	208	13	-	-	PUNCT
admet-579	208	14	limited	limited	ADJ
admet-579	208	15	,	,	PUNCT
admet-579	208	16	well	well	ADV
admet-579	208	17	-	-	PUNCT
admet-579	208	18	stirred	stir	VERB
admet-579	208	19	”	"	PUNCT
admet-579	208	20	model	model	NOUN
admet-579	208	21	has	have	AUX
admet-579	208	22	been	be	AUX
admet-579	208	23	assumed	assume	VERB
admet-579	208	24	for	for	ADP
admet-579	208	25	the	the	DET
admet-579	208	26	tissue	tissue	NOUN
admet-579	208	27	pk	pk	NOUN
admet-579	208	28	.	.	PUNCT
admet-579	209	1	this	this	PRON
admet-579	209	2	assumes	assume	VERB
admet-579	209	3	that	that	SCONJ
admet-579	209	4	the	the	DET
admet-579	209	5	free	free	ADJ
admet-579	209	6	,	,	PUNCT
admet-579	209	7	unbound	unbound	ADJ
admet-579	209	8	concentration	concentration	NOUN
admet-579	209	9	in	in	ADP
admet-579	209	10	the	the	DET
admet-579	209	11	tissue	tissue	NOUN
admet-579	209	12	space	space	NOUN
admet-579	209	13	is	be	AUX
admet-579	209	14	uniform	uniform	ADJ
admet-579	209	15	for	for	ADP
admet-579	209	16	the	the	DET
admet-579	209	17	entire	entire	ADJ
admet-579	209	18	tissue	tissue	NOUN
admet-579	209	19	and	and	CCONJ
admet-579	209	20	is	be	AUX
admet-579	209	21	equal	equal	ADJ
admet-579	209	22	to	to	ADP
admet-579	209	23	the	the	DET
admet-579	209	24	free	free	ADJ
admet-579	209	25	plasma	plasma	NOUN
admet-579	209	26	concentration	concentration	NOUN
admet-579	209	27	that	that	PRON
admet-579	209	28	leaves	leave	VERB
admet-579	209	29	the	the	DET
admet-579	209	30	organ	organ	NOUN
admet-579	209	31	in	in	ADP
admet-579	209	32	the	the	DET
admet-579	209	33	vein	vein	NOUN
admet-579	209	34	.	.	PUNCT
admet-579	210	1	this	this	PRON
admet-579	210	2	assumes	assume	VERB
admet-579	210	3	,	,	PUNCT
admet-579	210	4	in	in	ADP
admet-579	210	5	essence	essence	NOUN
admet-579	210	6	,	,	PUNCT
admet-579	210	7	that	that	SCONJ
admet-579	210	8	the	the	DET
admet-579	210	9	capillary	capillary	ADJ
admet-579	210	10	permeability	permeability	NOUN
admet-579	210	11	is	be	AUX
admet-579	210	12	infinite	infinite	ADJ
admet-579	210	13	.	.	PUNCT
admet-579	211	1	this	this	DET
admet-579	211	2	assumption	assumption	NOUN
admet-579	211	3	may	may	AUX
admet-579	211	4	be	be	AUX
admet-579	211	5	incorrect	incorrect	ADJ
admet-579	211	6	because	because	SCONJ
admet-579	211	7	the	the	DET
admet-579	211	8	ecs	ecs	NOUN
admet-579	211	9	solutes	solute	NOUN
admet-579	211	10	can	can	AUX
admet-579	211	11	not	not	PART
admet-579	211	12	penetrate	penetrate	VERB
admet-579	211	13	cell	cell	NOUN
admet-579	211	14	membranes	membrane	NOUN
admet-579	211	15	and	and	CCONJ
admet-579	211	16	must	must	AUX
admet-579	211	17	traverse	traverse	VERB
admet-579	211	18	the	the	DET
admet-579	211	19	capillary	capillary	ADJ
admet-579	211	20	wall	wall	NOUN
admet-579	211	21	through	through	ADP
admet-579	211	22	the	the	DET
admet-579	211	23	potentially	potentially	ADV
admet-579	211	24	limiting	limit	VERB
admet-579	211	25	interendothelial	interendothelial	ADJ
admet-579	211	26	slits	slit	NOUN
admet-579	211	27	[	[	X
admet-579	211	28	21	21	NUM
admet-579	211	29	]	]	PUNCT
admet-579	211	30	.	.	PUNCT
admet-579	212	1	figure	figure	NOUN
admet-579	212	2	11	11	NUM
admet-579	212	3	.	.	PUNCT
admet-579	213	1	semi	semi	ADJ
admet-579	213	2	-	-	ADJ
admet-579	213	3	log	log	ADJ
admet-579	213	4	plot	plot	NOUN
admet-579	213	5	of	of	ADP
admet-579	213	6	comparison	comparison	NOUN
admet-579	213	7	of	of	ADP
admet-579	213	8	experimental	experimental	ADJ
admet-579	213	9	antecubital	antecubital	ADJ
admet-579	213	10	amoxicillin	amoxicillin	NOUN
admet-579	213	11	concentration	concentration	NOUN
admet-579	213	12	(	(	PUNCT
admet-579	213	13	blue	blue	ADJ
admet-579	213	14	circles	circle	NOUN
admet-579	213	15	)	)	PUNCT
admet-579	213	16	and	and	CCONJ
admet-579	213	17	pkquest	pkqu	ADJ
admet-579	213	18	pbpk	pbpk	NOUN
admet-579	213	19	predicted	predict	VERB
admet-579	213	20	antecubital	antecubital	ADJ
admet-579	213	21	concentration	concentration	NOUN
admet-579	213	22	(	(	PUNCT
admet-579	213	23	red	red	ADJ
admet-579	213	24	line	line	NOUN
admet-579	213	25	)	)	PUNCT
admet-579	213	26	following	follow	VERB
admet-579	213	27	a	a	DET
admet-579	213	28	bolus	bolus	NOUN
admet-579	213	29	iv	iv	NUM
admet-579	213	30	input	input	NOUN
admet-579	213	31	.	.	PUNCT
admet-579	214	1	there	there	PRON
admet-579	214	2	is	be	VERB
admet-579	214	3	no	no	DET
admet-579	214	4	question	question	NOUN
admet-579	214	5	that	that	SCONJ
admet-579	214	6	some	some	DET
admet-579	214	7	ecs	ecs	NOUN
admet-579	214	8	solutes	solute	NOUN
admet-579	214	9	have	have	AUX
admet-579	214	10	a	a	DET
admet-579	214	11	capillary	capillary	ADJ
admet-579	214	12	permeability	permeability	NOUN
admet-579	214	13	limitation	limitation	NOUN
admet-579	214	14	.	.	PUNCT
admet-579	215	1	the	the	DET
admet-579	215	2	classical	classical	ADJ
admet-579	215	3	example	example	NOUN
admet-579	215	4	is	be	AUX
admet-579	215	5	inulin	inulin	NOUN
admet-579	215	6	,	,	PUNCT
admet-579	215	7	whose	whose	DET
admet-579	215	8	capillary	capillary	ADJ
admet-579	215	9	permeability	permeability	NOUN
admet-579	215	10	has	have	AUX
admet-579	215	11	been	be	AUX
admet-579	215	12	determined	determine	VERB
admet-579	215	13	in	in	ADP
admet-579	215	14	animal	animal	NOUN
admet-579	215	15	models	model	NOUN
admet-579	215	16	using	use	VERB
admet-579	215	17	a	a	DET
admet-579	215	18	variety	variety	NOUN
admet-579	215	19	of	of	ADP
admet-579	215	20	david	david	PROPN
admet-579	215	21	levitt	levitt	PROPN
admet-579	215	22	admet	admet	PROPN
admet-579	215	23	&	&	CCONJ
admet-579	215	24	dmpk	dmpk	PROPN
admet-579	215	25	7(1	7(1	PROPN
admet-579	215	26	)	)	PUNCT
admet-579	215	27	(	(	PUNCT
admet-579	215	28	2019)60	2019)60	NUM
admet-579	215	29	-	-	SYM
admet-579	215	30	75	75	NUM
admet-579	215	31	72	72	NUM
admet-579	215	32	experimental	experimental	ADJ
admet-579	215	33	approaches	approach	NOUN
admet-579	215	34	[	[	X
admet-579	215	35	21	21	NUM
admet-579	215	36	]	]	PUNCT
admet-579	215	37	.	.	PUNCT
admet-579	216	1	pkquest	pkquest	PROPN
admet-579	216	2	has	have	AUX
admet-579	216	3	been	be	AUX
admet-579	216	4	modified	modify	VERB
admet-579	216	5	to	to	PART
admet-579	216	6	allow	allow	VERB
admet-579	216	7	for	for	ADP
admet-579	216	8	a	a	DET
admet-579	216	9	capillary	capillary	ADJ
admet-579	216	10	permeability	permeability	NOUN
admet-579	216	11	limitation	limitation	NOUN
admet-579	216	12	characterized	characterize	VERB
admet-579	216	13	by	by	ADP
admet-579	216	14	the	the	DET
admet-579	216	15	parameter	parameter	NOUN
admet-579	216	16	“	"	PUNCT
admet-579	216	17	flcr	flcr	NOUN
admet-579	216	18	”	"	PUNCT
admet-579	216	19	,	,	PUNCT
admet-579	216	20	the	the	DET
admet-579	216	21	fraction	fraction	NOUN
admet-579	216	22	of	of	ADP
admet-579	216	23	plasma	plasma	NOUN
admet-579	216	24	solute	solute	NOUN
admet-579	216	25	that	that	PRON
admet-579	216	26	equilibrates	equilibrate	VERB
admet-579	216	27	with	with	ADP
admet-579	216	28	the	the	DET
admet-579	216	29	interstitial	interstitial	ADJ
admet-579	216	30	space	space	NOUN
admet-579	216	31	in	in	ADP
admet-579	216	32	one	one	NUM
admet-579	216	33	pass	pass	NOUN
admet-579	216	34	through	through	ADP
admet-579	216	35	the	the	DET
admet-579	216	36	capillary	capillary	NOUN
admet-579	216	37	.	.	PUNCT
admet-579	217	1	it	it	PRON
admet-579	217	2	is	be	AUX
admet-579	217	3	defined	define	VERB
admet-579	217	4	by	by	ADP
admet-579	217	5	:	:	PUNCT
admet-579	217	6	i	i	PRON
admet-579	217	7	i	i	PRON
admet-579	218	1	a	a	PRON
admet-579	218	2	v	v	NOUN
admet-579	219	1	i	i	PRON
admet-579	219	2	a	a	DET
admet-579	219	3	t	t	NOUN
admet-579	219	4	fclr	fclr	NOUN
admet-579	219	5	c	c	PROPN
admet-579	220	1	c	c	NOUN
admet-579	220	2	c	c	NOUN
admet-579	220	3	c	c	PROPN
admet-579	220	4			PROPN
admet-579	220	5			PROPN
admet-579	220	6			NOUN
admet-579	220	7	(	(	PUNCT
admet-579	220	8	10	10	NUM
admet-579	220	9	)	)	PUNCT
admet-579	220	10	where	where	SCONJ
admet-579	220	11	ca	can	AUX
admet-579	220	12	,	,	PUNCT
admet-579	220	13	cv	cv	PROPN
admet-579	220	14	i	i	PROPN
admet-579	220	15	and	and	CCONJ
admet-579	220	16	ct	ct	PRON
admet-579	221	1	i	i	PRON
admet-579	221	2	are	be	AUX
admet-579	221	3	the	the	DET
admet-579	221	4	free	free	ADJ
admet-579	221	5	unbound	unbound	NOUN
admet-579	221	6	concentrations	concentration	NOUN
admet-579	221	7	in	in	ADP
admet-579	221	8	the	the	DET
admet-579	221	9	artery	artery	NOUN
admet-579	221	10	,	,	PUNCT
admet-579	221	11	vein	vein	NOUN
admet-579	221	12	and	and	CCONJ
admet-579	221	13	tissue	tissue	NOUN
admet-579	221	14	,	,	PUNCT
admet-579	221	15	respectively	respectively	ADV
admet-579	221	16	.	.	PUNCT
admet-579	222	1	if	if	SCONJ
admet-579	222	2	the	the	DET
admet-579	222	3	capillary	capillary	ADJ
admet-579	222	4	permeability	permeability	NOUN
admet-579	222	5	is	be	AUX
admet-579	222	6	infinite	infinite	ADJ
admet-579	222	7	,	,	PUNCT
admet-579	222	8	cv	cv	PROPN
admet-579	222	9	i	i	NOUN
admet-579	222	10	=	=	PROPN
admet-579	223	1	ct	ct	PROPN
admet-579	223	2	i	i	PRON
admet-579	223	3	and	and	CCONJ
admet-579	223	4	fclr	fclr	NOUN
admet-579	223	5	=	=	SYM
admet-579	224	1	1	1	X
admet-579	224	2	.	.	PUNCT
admet-579	225	1	if	if	SCONJ
admet-579	225	2	the	the	DET
admet-579	225	3	permeability	permeability	NOUN
admet-579	225	4	is	be	AUX
admet-579	225	5	0	0	NUM
admet-579	225	6	,	,	PUNCT
admet-579	225	7	ca	ca	NOUN
admet-579	225	8	=	=	NOUN
admet-579	225	9	cv	cv	ADJ
admet-579	225	10	and	and	CCONJ
admet-579	225	11	fclr	fclr	NOUN
admet-579	225	12	=	=	SYM
admet-579	225	13	0	0	X
admet-579	225	14	.	.	PUNCT
admet-579	226	1	in	in	ADP
admet-579	226	2	pkquest	pkqu	ADJ
admet-579	226	3	,	,	PUNCT
admet-579	226	4	the	the	DET
admet-579	226	5	input	input	NOUN
admet-579	226	6	parameter	parameter	NOUN
admet-579	226	7	“	"	PUNCT
admet-579	226	8	cap	cap	NOUN
admet-579	226	9	perm	perm	NOUN
admet-579	226	10	”	"	PUNCT
admet-579	226	11	(	(	PUNCT
admet-579	226	12	fig	fig	NOUN
admet-579	226	13	.	.	PUNCT
admet-579	226	14	9	9	NUM
admet-579	226	15	)	)	PUNCT
admet-579	226	16	is	be	AUX
admet-579	226	17	the	the	DET
admet-579	226	18	fclrmuscle	fclrmuscle	NOUN
admet-579	226	19	.	.	PUNCT
admet-579	227	1	the	the	DET
admet-579	227	2	flcr	flcr	NOUN
admet-579	227	3	of	of	ADP
admet-579	227	4	the	the	DET
admet-579	227	5	other	other	ADJ
admet-579	227	6	tissues	tissue	NOUN
admet-579	227	7	are	be	AUX
admet-579	227	8	then	then	ADV
admet-579	227	9	set	set	VERB
admet-579	227	10	equal	equal	ADJ
admet-579	227	11	to	to	ADP
admet-579	227	12	proportional	proportional	ADJ
admet-579	227	13	values	value	NOUN
admet-579	227	14	determined	determine	VERB
admet-579	227	15	from	from	ADP
admet-579	227	16	a	a	DET
admet-579	227	17	literature	literature	NOUN
admet-579	227	18	review	review	NOUN
admet-579	227	19	[	[	X
admet-579	227	20	7	7	NUM
admet-579	227	21	]	]	PUNCT
admet-579	227	22	.	.	PUNCT
admet-579	228	1	figure	figure	NOUN
admet-579	228	2	12	12	NUM
admet-579	228	3	shows	show	VERB
admet-579	228	4	a	a	DET
admet-579	228	5	comparison	comparison	NOUN
admet-579	228	6	of	of	ADP
admet-579	228	7	the	the	DET
admet-579	228	8	permeability	permeability	NOUN
admet-579	228	9	limited	limit	VERB
admet-579	228	10	(	(	PUNCT
admet-579	228	11	top	top	ADJ
admet-579	228	12	panel	panel	NOUN
admet-579	228	13	)	)	PUNCT
admet-579	228	14	versus	versus	ADP
admet-579	228	15	infinite	infinite	ADJ
admet-579	228	16	permeability	permeability	NOUN
admet-579	228	17	(	(	PUNCT
admet-579	228	18	bottom	bottom	ADJ
admet-579	228	19	panel	panel	NOUN
admet-579	228	20	)	)	PUNCT
admet-579	228	21	pkquest	pkquest	NOUN
admet-579	228	22	pbpk	pbpk	NOUN
admet-579	228	23	fit	fit	ADJ
admet-579	228	24	to	to	ADP
admet-579	228	25	the	the	DET
admet-579	228	26	inulin	inulin	ADJ
admet-579	228	27	data	datum	NOUN
admet-579	228	28	of	of	ADP
admet-579	228	29	odeh	odeh	NOUN
admet-579	228	30	et	et	NOUN
admet-579	228	31	al	al	PROPN
admet-579	228	32	.	.	PUNCT
admet-579	229	1	[	[	X
admet-579	229	2	22	22	NUM
admet-579	229	3	]	]	PUNCT
admet-579	229	4	.	.	PUNCT
admet-579	230	1	it	it	PRON
admet-579	230	2	can	can	AUX
admet-579	230	3	be	be	AUX
admet-579	230	4	seen	see	VERB
admet-579	230	5	that	that	SCONJ
admet-579	230	6	although	although	SCONJ
admet-579	230	7	the	the	DET
admet-579	230	8	permeability	permeability	NOUN
admet-579	230	9	limitation	limitation	NOUN
admet-579	230	10	only	only	ADV
admet-579	230	11	affects	affect	VERB
admet-579	230	12	the	the	DET
admet-579	230	13	early	early	ADJ
admet-579	230	14	time	time	NOUN
admet-579	230	15	data	datum	NOUN
admet-579	230	16	and	and	CCONJ
admet-579	230	17	is	be	AUX
admet-579	230	18	a	a	DET
admet-579	230	19	relatively	relatively	ADV
admet-579	230	20	small	small	ADJ
admet-579	230	21	effect	effect	NOUN
admet-579	230	22	,	,	PUNCT
admet-579	230	23	the	the	DET
admet-579	230	24	addition	addition	NOUN
admet-579	230	25	of	of	ADP
admet-579	230	26	the	the	DET
admet-579	230	27	limitation	limitation	NOUN
admet-579	230	28	clearly	clearly	ADV
admet-579	230	29	improves	improve	VERB
admet-579	230	30	the	the	DET
admet-579	230	31	fit	fit	NOUN
admet-579	230	32	.	.	PUNCT
admet-579	231	1	the	the	DET
admet-579	231	2	best	good	ADJ
admet-579	231	3	fit	fit	NOUN
admet-579	231	4	was	be	AUX
admet-579	231	5	obtained	obtain	VERB
admet-579	231	6	with	with	ADP
admet-579	231	7	the	the	DET
admet-579	231	8	fclrmuslc	fclrmuslc	NOUN
admet-579	231	9	of	of	ADP
admet-579	231	10	0.45	0.45	NUM
admet-579	231	11	which	which	PRON
admet-579	231	12	corresponds	correspond	VERB
admet-579	231	13	to	to	ADP
admet-579	231	14	a	a	DET
admet-579	231	15	capillary	capillary	ADJ
admet-579	231	16	permeability	permeability	NOUN
admet-579	231	17	(	(	PUNCT
admet-579	231	18	ps	ps	PROPN
admet-579	231	19	,	,	PUNCT
admet-579	231	20	eq	eq	NOUN
admet-579	231	21	.	.	PUNCT
admet-579	232	1	(	(	PUNCT
admet-579	232	2	11	11	NUM
admet-579	232	3	)	)	PUNCT
admet-579	232	4	)	)	PUNCT
admet-579	232	5	of	of	ADP
admet-579	232	6	skeletal	skeletal	ADJ
admet-579	232	7	muscle	muscle	NOUN
admet-579	232	8	of	of	ADP
admet-579	232	9	0.61	0.61	NUM
admet-579	232	10	ml	ml	NOUN
admet-579	232	11	/	/	SYM
admet-579	232	12	min/100	min/100	PRON
admet-579	232	13	gm	gm	PROPN
admet-579	232	14	,	,	PUNCT
admet-579	232	15	similar	similar	ADJ
admet-579	232	16	to	to	ADP
admet-579	232	17	that	that	PRON
admet-579	232	18	determined	determine	VERB
admet-579	232	19	directly	directly	ADV
admet-579	232	20	in	in	ADP
admet-579	232	21	animal	animal	NOUN
admet-579	232	22	studies	study	NOUN
admet-579	232	23	[	[	X
admet-579	232	24	21	21	NUM
admet-579	232	25	]	]	PUNCT
admet-579	232	26	.	.	PUNCT
admet-579	233	1	this	this	DET
admet-579	233	2	pbpk	pbpk	PROPN
admet-579	233	3	approach	approach	NOUN
admet-579	233	4	represents	represent	VERB
admet-579	233	5	a	a	DET
admet-579	233	6	new	new	ADJ
admet-579	233	7	way	way	NOUN
admet-579	233	8	to	to	PART
admet-579	233	9	study	study	VERB
admet-579	233	10	capillary	capillary	ADJ
admet-579	233	11	permeability	permeability	NOUN
admet-579	233	12	and	and	CCONJ
admet-579	233	13	is	be	AUX
admet-579	233	14	the	the	DET
admet-579	233	15	first	first	ADJ
admet-579	233	16	human	human	ADJ
admet-579	233	17	measurement	measurement	NOUN
admet-579	233	18	of	of	ADP
admet-579	233	19	muscle	muscle	NOUN
admet-579	233	20	capillary	capillary	ADJ
admet-579	233	21	permeability	permeability	NOUN
admet-579	233	22	for	for	ADP
admet-579	233	23	these	these	DET
admet-579	233	24	solutes	solute	NOUN
admet-579	233	25	.	.	PUNCT
admet-579	234	1	figure	figure	VERB
admet-579	234	2	12.pkquest	12.pkquest	NUM
admet-579	234	3	pbpk	pbpk	ADJ
admet-579	234	4	pharmacokinetics	pharmacokinetic	NOUN
admet-579	234	5	(	(	PUNCT
admet-579	234	6	red	red	ADJ
admet-579	234	7	line	line	NOUN
admet-579	234	8	)	)	PUNCT
admet-579	234	9	for	for	ADP
admet-579	234	10	inulin	inulin	NOUN
admet-579	234	11	following	follow	VERB
admet-579	234	12	a	a	DET
admet-579	234	13	5	5	NUM
admet-579	234	14	minute	minute	NOUN
admet-579	234	15	constant	constant	ADJ
admet-579	234	16	iv	iv	NUM
admet-579	234	17	infusion	infusion	NOUN
admet-579	234	18	.	.	PUNCT
admet-579	235	1	the	the	DET
admet-579	235	2	top	top	ADJ
admet-579	235	3	panel	panel	NOUN
admet-579	235	4	is	be	AUX
admet-579	235	5	with	with	ADP
admet-579	235	6	a	a	DET
admet-579	235	7	capillary	capillary	ADJ
admet-579	235	8	permeability	permeability	NOUN
admet-579	235	9	limitation	limitation	NOUN
admet-579	235	10	(	(	PUNCT
admet-579	235	11	fclr	fclr	NOUN
admet-579	235	12	muscle	muscle	NOUN
admet-579	235	13	=	=	NOUN
admet-579	235	14	0.45	0.45	NUM
admet-579	235	15	)	)	PUNCT
admet-579	235	16	and	and	CCONJ
admet-579	235	17	the	the	DET
admet-579	235	18	bottom	bottom	ADJ
admet-579	235	19	panel	panel	NOUN
admet-579	235	20	is	be	AUX
admet-579	235	21	for	for	ADP
admet-579	235	22	an	an	DET
admet-579	235	23	infinite	infinite	ADJ
admet-579	235	24	permeability	permeability	NOUN
admet-579	235	25	(	(	PUNCT
admet-579	235	26	fclr	fclr	NOUN
admet-579	235	27	muscle	muscle	NOUN
admet-579	235	28	=	=	NOUN
admet-579	235	29	1	1	NUM
admet-579	235	30	)	)	PUNCT
admet-579	235	31	.	.	PUNCT
admet-579	236	1	admet	admet	PROPN
admet-579	236	2	&	&	CCONJ
admet-579	236	3	dmpk	dmpk	PROPN
admet-579	236	4	7(1	7(1	PROPN
admet-579	236	5	)	)	PUNCT
admet-579	236	6	(	(	PUNCT
admet-579	236	7	2019	2019	NUM
admet-579	236	8	)	)	PUNCT
admet-579	236	9	60	60	NUM
admet-579	236	10	-	-	SYM
admet-579	236	11	75	75	NUM
admet-579	236	12	lipid	lipid	NOUN
admet-579	236	13	soluble	soluble	ADJ
admet-579	236	14	and	and	CCONJ
admet-579	236	15	extracellular	extracellular	ADJ
admet-579	236	16	solutes	solute	NOUN
admet-579	236	17	doi	doi	NOUN
admet-579	236	18	:	:	PUNCT
admet-579	236	19	10.5599	10.5599	NUM
admet-579	236	20	/	/	SYM
admet-579	236	21	admet.579	admet.579	NOUN
admet-579	236	22	73	73	NUM
admet-579	236	23	it	it	PRON
admet-579	236	24	had	have	AUX
admet-579	236	25	not	not	PART
admet-579	236	26	been	be	AUX
admet-579	236	27	previously	previously	ADV
admet-579	236	28	recognized	recognize	VERB
admet-579	236	29	that	that	SCONJ
admet-579	236	30	,	,	PUNCT
admet-579	236	31	as	as	ADP
admet-579	236	32	the	the	DET
admet-579	236	33	albumin	albumin	ADJ
admet-579	236	34	binding	bind	VERB
admet-579	236	35	affinity	affinity	NOUN
admet-579	236	36	increases	increase	NOUN
admet-579	236	37	,	,	PUNCT
admet-579	236	38	the	the	DET
admet-579	236	39	capillary	capillary	ADJ
admet-579	236	40	permeability	permeability	NOUN
admet-579	236	41	should	should	AUX
admet-579	236	42	decrease	decrease	VERB
admet-579	236	43	.	.	PUNCT
admet-579	237	1	one	one	PRON
admet-579	237	2	can	can	AUX
admet-579	237	3	show	show	VERB
admet-579	237	4	that	that	SCONJ
admet-579	237	5	the	the	DET
admet-579	237	6	parameter	parameter	NOUN
admet-579	237	7	fclr	fclr	NOUN
admet-579	237	8	i	i	PRON
admet-579	237	9	is	be	AUX
admet-579	237	10	described	describe	VERB
admet-579	237	11	by	by	ADP
admet-579	237	12	the	the	DET
admet-579	237	13	relation	relation	NOUN
admet-579	238	1	[	[	X
admet-579	238	2	3,4,7	3,4,7	NUM
admet-579	238	3	]	]	X
admet-579	238	4	:	:	PUNCT
admet-579	238	5	i	i	PRON
admet-579	238	6	i	i	PRON
admet-579	238	7	ifclr	ifclr	VERB
admet-579	238	8	1	1	NUM
admet-579	238	9	exp	exp	NOUN
admet-579	238	10	(	(	PUNCT
admet-579	238	11	/	/	SYM
admet-579	238	12	)	)	PUNCT
admet-579	238	13	pf	pf	PROPN
admet-579	238	14	ps	ps	PROPN
admet-579	238	15	f	f	PROPN
admet-579	238	16			PROPN
admet-579	238	17			NOUN
admet-579	238	18	(	(	PUNCT
admet-579	238	19	11	11	NUM
admet-579	238	20	)	)	PUNCT
admet-579	238	21	where	where	SCONJ
admet-579	238	22	fp	fp	PROPN
admet-579	238	23	is	be	AUX
admet-579	238	24	the	the	DET
admet-579	238	25	fraction	fraction	NOUN
admet-579	238	26	free	free	ADJ
admet-579	238	27	in	in	ADP
admet-579	238	28	plasma	plasma	NOUN
admet-579	238	29	,	,	PUNCT
admet-579	238	30	p	p	NOUN
admet-579	238	31	is	be	AUX
admet-579	238	32	the	the	DET
admet-579	238	33	capillary	capillary	ADJ
admet-579	238	34	permeability	permeability	NOUN
admet-579	238	35	of	of	ADP
admet-579	238	36	the	the	DET
admet-579	238	37	free	free	ADJ
admet-579	238	38	,	,	PUNCT
admet-579	238	39	unbound	unbound	NOUN
admet-579	238	40	solute	solute	NOUN
admet-579	238	41	,	,	PUNCT
admet-579	238	42	and	and	CCONJ
admet-579	238	43	s	s	VERB
admet-579	238	44	i	i	PRON
admet-579	238	45	and	and	CCONJ
admet-579	238	46	f	f	PRON
admet-579	239	1	i	i	PRON
admet-579	239	2	are	be	AUX
admet-579	239	3	the	the	DET
admet-579	239	4	capillary	capillary	ADJ
admet-579	239	5	surface	surface	NOUN
admet-579	239	6	area	area	NOUN
admet-579	239	7	and	and	CCONJ
admet-579	239	8	flow	flow	NOUN
admet-579	239	9	rate	rate	NOUN
admet-579	239	10	for	for	ADP
admet-579	239	11	tissue	tissue	NOUN
admet-579	239	12	i.	i.	NOUN
admet-579	239	13	as	as	ADP
admet-579	239	14	p	p	NOUN
admet-579	239	15	approaches	approach	NOUN
admet-579	239	16	infinity	infinity	NOUN
admet-579	239	17	,	,	PUNCT
admet-579	239	18	fclr	fclr	NOUN
admet-579	239	19	approaches	approach	VERB
admet-579	239	20	1	1	NUM
admet-579	239	21	and	and	CCONJ
admet-579	239	22	the	the	DET
admet-579	239	23	solute	solute	NOUN
admet-579	239	24	becomes	become	VERB
admet-579	239	25	flow	flow	NOUN
admet-579	239	26	limited	limited	ADJ
admet-579	239	27	.	.	PUNCT
admet-579	240	1	it	it	PRON
admet-579	240	2	can	can	AUX
admet-579	240	3	be	be	AUX
admet-579	240	4	seen	see	VERB
admet-579	240	5	that	that	SCONJ
admet-579	240	6	solutes	solute	NOUN
admet-579	240	7	that	that	PRON
admet-579	240	8	have	have	VERB
admet-579	240	9	a	a	DET
admet-579	240	10	high	high	ADJ
admet-579	240	11	“	"	PUNCT
admet-579	240	12	intrinsic	intrinsic	ADJ
admet-579	240	13	”	"	PUNCT
admet-579	240	14	p	p	NOUN
admet-579	240	15	if	if	SCONJ
admet-579	240	16	they	they	PRON
admet-579	240	17	are	be	AUX
admet-579	240	18	unbound	unbound	NOUN
admet-579	240	19	,	,	PUNCT
admet-579	240	20	may	may	AUX
admet-579	240	21	become	become	VERB
admet-579	240	22	capillary	capillary	ADJ
admet-579	240	23	limited	limit	VERB
admet-579	240	24	as	as	ADP
admet-579	240	25	the	the	DET
admet-579	240	26	albumin	albumin	ADJ
admet-579	240	27	binding	bind	VERB
admet-579	240	28	affinity	affinity	NOUN
admet-579	240	29	increases	increase	NOUN
admet-579	240	30	and	and	CCONJ
admet-579	240	31	fp	fp	X
admet-579	240	32	approaches	approach	NOUN
admet-579	240	33	zero	zero	NUM
admet-579	240	34	.	.	PUNCT
admet-579	241	1	this	this	DET
admet-579	241	2	fp	fp	INTJ
admet-579	241	3	dependence	dependence	NOUN
admet-579	241	4	of	of	ADP
admet-579	241	5	the	the	DET
admet-579	241	6	capillary	capillary	ADJ
admet-579	241	7	permeability	permeability	NOUN
admet-579	241	8	was	be	AUX
admet-579	241	9	tested	test	VERB
admet-579	241	10	using	use	VERB
admet-579	241	11	the	the	DET
admet-579	241	12	experimental	experimental	ADJ
admet-579	241	13	pk	pk	NOUN
admet-579	241	14	of	of	ADP
admet-579	241	15	a	a	DET
admet-579	241	16	series	series	NOUN
admet-579	241	17	of	of	ADP
admet-579	241	18	βlactam	βlactam	NOUN
admet-579	241	19	antibiotics	antibiotic	NOUN
admet-579	241	20	with	with	ADP
admet-579	241	21	fp	fp	X
admet-579	241	22	varying	vary	VERB
admet-579	241	23	from	from	ADP
admet-579	241	24	0.8	0.8	NUM
admet-579	241	25	for	for	ADP
admet-579	241	26	amoxicillin	amoxicillin	NOUN
admet-579	241	27	,	,	PUNCT
admet-579	241	28	to	to	ADP
admet-579	241	29	0.52	0.52	NUM
admet-579	241	30	for	for	ADP
admet-579	241	31	piperacillin	piperacillin	NOUN
admet-579	241	32	,	,	PUNCT
admet-579	241	33	to	to	ADP
admet-579	241	34	0.07	0.07	NUM
admet-579	241	35	for	for	ADP
admet-579	241	36	flucloxacillin	flucloxacillin	NOUN
admet-579	241	37	and	and	CCONJ
admet-579	241	38	0.03	0.03	NUM
admet-579	241	39	for	for	ADP
admet-579	241	40	dicloxacillin	dicloxacillin	NOUN
admet-579	242	1	[	[	X
admet-579	242	2	7	7	NUM
admet-579	242	3	]	]	PUNCT
admet-579	242	4	.	.	PUNCT
admet-579	243	1	the	the	DET
admet-579	243	2	quality	quality	NOUN
admet-579	243	3	of	of	ADP
admet-579	243	4	the	the	DET
admet-579	243	5	pkquest	pkqu	ADJ
admet-579	243	6	pbpk	pbpk	PROPN
admet-579	243	7	fits	fit	VERB
admet-579	243	8	to	to	ADP
admet-579	243	9	the	the	DET
admet-579	243	10	experimental	experimental	ADJ
admet-579	243	11	data	datum	NOUN
admet-579	243	12	with	with	ADP
admet-579	243	13	and	and	CCONJ
admet-579	243	14	without	without	ADP
admet-579	243	15	a	a	DET
admet-579	243	16	capillary	capillary	ADJ
admet-579	243	17	permeability	permeability	NOUN
admet-579	243	18	limitation	limitation	NOUN
admet-579	243	19	was	be	AUX
admet-579	243	20	compared	compare	VERB
admet-579	243	21	.	.	PUNCT
admet-579	244	1	for	for	ADP
admet-579	244	2	flucloxacillin	flucloxacillin	NOUN
admet-579	244	3	and	and	CCONJ
admet-579	244	4	dicloxacillin	dicloxacillin	PROPN
admet-579	244	5	,	,	PUNCT
admet-579	244	6	the	the	DET
admet-579	244	7	two	two	NUM
admet-579	244	8	solutes	solute	NOUN
admet-579	244	9	with	with	ADP
admet-579	244	10	the	the	DET
admet-579	244	11	highest	high	ADJ
admet-579	244	12	albumin	albumin	ADJ
admet-579	244	13	binding	binding	NOUN
admet-579	244	14	,	,	PUNCT
admet-579	244	15	the	the	DET
admet-579	244	16	fit	fit	NOUN
admet-579	244	17	clearly	clearly	ADV
admet-579	244	18	improved	improve	VERB
admet-579	244	19	when	when	SCONJ
admet-579	244	20	a	a	DET
admet-579	244	21	permeability	permeability	NOUN
admet-579	244	22	limitation	limitation	NOUN
admet-579	244	23	was	be	AUX
admet-579	244	24	introduced	introduce	VERB
admet-579	244	25	.	.	PUNCT
admet-579	245	1	figure	figure	NOUN
admet-579	245	2	13	13	NUM
admet-579	245	3	shows	show	VERB
admet-579	245	4	a	a	DET
admet-579	245	5	comparison	comparison	NOUN
admet-579	245	6	of	of	ADP
admet-579	245	7	the	the	DET
admet-579	245	8	pkquest	pkqu	ADJ
admet-579	245	9	output	output	NOUN
admet-579	245	10	for	for	ADP
admet-579	245	11	dicloxacillin	dicloxacillin	NOUN
admet-579	245	12	with	with	ADP
admet-579	245	13	a	a	DET
admet-579	245	14	permeability	permeability	NOUN
admet-579	245	15	limitation	limitation	NOUN
admet-579	245	16	(	(	PUNCT
admet-579	245	17	top	top	ADJ
admet-579	245	18	panel	panel	NOUN
admet-579	245	19	,	,	PUNCT
admet-579	245	20	fclr	fclr	NOUN
admet-579	245	21	muscle	muscle	NOUN
admet-579	245	22	=	=	NOUN
admet-579	245	23	0.3	0.3	NUM
admet-579	245	24	)	)	PUNCT
admet-579	245	25	versus	versus	ADP
admet-579	245	26	infinite	infinite	ADJ
admet-579	245	27	permeability	permeability	NOUN
admet-579	245	28	(	(	PUNCT
admet-579	245	29	bottom	bottom	ADJ
admet-579	245	30	panel	panel	NOUN
admet-579	245	31	,	,	PUNCT
admet-579	245	32	fclr	fclr	NOUN
admet-579	245	33	muscle	muscle	NOUN
admet-579	245	34	=	=	NOUN
admet-579	245	35	1	1	NUM
admet-579	245	36	)	)	PUNCT
admet-579	245	37	.	.	PUNCT
admet-579	246	1	again	again	ADV
admet-579	246	2	it	it	PRON
admet-579	246	3	can	can	AUX
admet-579	246	4	be	be	AUX
admet-579	246	5	seen	see	VERB
admet-579	246	6	that	that	SCONJ
admet-579	246	7	although	although	SCONJ
admet-579	246	8	the	the	DET
admet-579	246	9	permeability	permeability	NOUN
admet-579	246	10	limitation	limitation	NOUN
admet-579	246	11	only	only	ADV
admet-579	246	12	affects	affect	VERB
admet-579	246	13	the	the	DET
admet-579	246	14	early	early	ADJ
admet-579	246	15	time	time	NOUN
admet-579	246	16	data	datum	NOUN
admet-579	246	17	and	and	CCONJ
admet-579	246	18	is	be	AUX
admet-579	246	19	a	a	DET
admet-579	246	20	relatively	relatively	ADV
admet-579	246	21	small	small	ADJ
admet-579	246	22	effect	effect	NOUN
admet-579	246	23	,	,	PUNCT
admet-579	246	24	the	the	DET
admet-579	246	25	addition	addition	NOUN
admet-579	246	26	of	of	ADP
admet-579	246	27	the	the	DET
admet-579	246	28	limitation	limitation	NOUN
admet-579	246	29	clearly	clearly	ADV
admet-579	246	30	improves	improve	VERB
admet-579	246	31	the	the	DET
admet-579	246	32	fit	fit	NOUN
admet-579	246	33	.	.	PUNCT
admet-579	247	1	the	the	DET
admet-579	247	2	estimated	estimate	VERB
admet-579	247	3	pbpk	pbpk	NOUN
admet-579	247	4	human	human	ADJ
admet-579	247	5	ps	ps	PROPN
admet-579	247	6	values	value	NOUN
admet-579	247	7	are	be	AUX
admet-579	247	8	similar	similar	ADJ
admet-579	247	9	to	to	ADP
admet-579	247	10	those	those	PRON
admet-579	247	11	of	of	ADP
admet-579	247	12	edta	edta	NOUN
admet-579	247	13	and	and	CCONJ
admet-579	247	14	mannitol	mannitol	NOUN
admet-579	247	15	,	,	PUNCT
admet-579	247	16	ecs	ecs	NOUN
admet-579	247	17	solutes	solute	NOUN
admet-579	247	18	of	of	ADP
admet-579	247	19	similar	similar	ADJ
admet-579	247	20	size	size	NOUN
admet-579	247	21	,	,	PUNCT
admet-579	247	22	measured	measure	VERB
admet-579	247	23	directly	directly	ADV
admet-579	247	24	in	in	ADP
admet-579	247	25	the	the	DET
admet-579	247	26	cat	cat	NOUN
admet-579	248	1	[	[	X
admet-579	248	2	7	7	NUM
admet-579	248	3	]	]	PUNCT
admet-579	248	4	.	.	PUNCT
admet-579	249	1	figure	figure	VERB
admet-579	249	2	13.pkquest	13.pkquest	NUM
admet-579	249	3	pbpk	pbpk	ADJ
admet-579	249	4	pharmacokinetics	pharmacokinetic	NOUN
admet-579	249	5	(	(	PUNCT
admet-579	249	6	red	red	ADJ
admet-579	249	7	line	line	NOUN
admet-579	249	8	)	)	PUNCT
admet-579	249	9	for	for	ADP
admet-579	249	10	dicloxacillin	dicloxacillin	NOUN
admet-579	249	11	following	follow	VERB
admet-579	249	12	a	a	DET
admet-579	249	13	30	30	NUM
admet-579	249	14	minute	minute	NOUN
admet-579	249	15	constant	constant	ADJ
admet-579	249	16	iv	iv	NUM
admet-579	249	17	infusion	infusion	NOUN
admet-579	249	18	.	.	PUNCT
admet-579	250	1	the	the	DET
admet-579	250	2	top	top	ADJ
admet-579	250	3	panel	panel	NOUN
admet-579	250	4	is	be	AUX
admet-579	250	5	with	with	ADP
admet-579	250	6	a	a	DET
admet-579	250	7	capillary	capillary	ADJ
admet-579	250	8	permeability	permeability	NOUN
admet-579	250	9	limitation	limitation	NOUN
admet-579	250	10	(	(	PUNCT
admet-579	250	11	fclr	fclr	NOUN
admet-579	250	12	muscle	muscle	NOUN
admet-579	250	13	=	=	NOUN
admet-579	250	14	0.3	0.3	NUM
admet-579	250	15	)	)	PUNCT
admet-579	250	16	and	and	CCONJ
admet-579	250	17	the	the	DET
admet-579	250	18	bottom	bottom	ADJ
admet-579	250	19	panel	panel	NOUN
admet-579	250	20	is	be	AUX
admet-579	250	21	for	for	ADP
admet-579	250	22	an	an	DET
admet-579	250	23	infinite	infinite	ADJ
admet-579	250	24	permeability	permeability	NOUN
admet-579	250	25	(	(	PUNCT
admet-579	250	26	fclr	fclr	NOUN
admet-579	250	27	muscle	muscle	NOUN
admet-579	250	28	=	=	NOUN
admet-579	250	29	1	1	NUM
admet-579	250	30	)	)	PUNCT
admet-579	250	31	.	.	PUNCT
admet-579	251	1	david	david	PROPN
admet-579	251	2	levitt	levitt	PROPN
admet-579	251	3	admet	admet	PROPN
admet-579	251	4	&	&	CCONJ
admet-579	251	5	dmpk	dmpk	PROPN
admet-579	251	6	7(1	7(1	PROPN
admet-579	251	7	)	)	PUNCT
admet-579	251	8	(	(	PUNCT
admet-579	251	9	2019)60	2019)60	NUM
admet-579	251	10	-	-	SYM
admet-579	251	11	75	75	NUM
admet-579	251	12	74	74	NUM
admet-579	251	13	the	the	DET
admet-579	251	14	possibility	possibility	NOUN
admet-579	251	15	of	of	ADP
admet-579	251	16	a	a	DET
admet-579	251	17	capillary	capillary	ADJ
admet-579	251	18	permeability	permeability	NOUN
admet-579	251	19	limitation	limitation	NOUN
admet-579	251	20	complicates	complicate	VERB
admet-579	251	21	the	the	DET
admet-579	251	22	pk	pk	NOUN
admet-579	251	23	of	of	ADP
admet-579	251	24	the	the	DET
admet-579	251	25	ecs	ecs	PROPN
admet-579	251	26	solutes	solute	NOUN
admet-579	251	27	.	.	PUNCT
admet-579	252	1	as	as	SCONJ
admet-579	252	2	shown	show	VERB
admet-579	252	3	above	above	ADV
admet-579	252	4	,	,	PUNCT
admet-579	252	5	for	for	ADP
admet-579	252	6	solutes	solute	NOUN
admet-579	252	7	the	the	DET
admet-579	252	8	size	size	NOUN
admet-579	252	9	of	of	ADP
admet-579	252	10	the	the	DET
admet-579	252	11	β	β	NOUN
admet-579	252	12	-	-	NOUN
admet-579	252	13	lactam	lactam	NOUN
admet-579	252	14	antibiotics	antibiotic	NOUN
admet-579	252	15	and	and	CCONJ
admet-579	252	16	fp	fp	X
admet-579	252	17	greater	great	ADJ
admet-579	252	18	than	than	ADP
admet-579	252	19	0.3	0.3	NUM
admet-579	252	20	,	,	PUNCT
admet-579	252	21	it	it	PRON
admet-579	252	22	can	can	AUX
admet-579	252	23	be	be	AUX
admet-579	252	24	assumed	assume	VERB
admet-579	252	25	that	that	SCONJ
admet-579	252	26	the	the	DET
admet-579	252	27	permeability	permeability	NOUN
admet-579	252	28	is	be	AUX
admet-579	252	29	infinite	infinite	ADJ
admet-579	252	30	.	.	PUNCT
admet-579	253	1	for	for	ADP
admet-579	253	2	larger	large	ADJ
admet-579	253	3	solutes	solute	NOUN
admet-579	253	4	(	(	PUNCT
admet-579	253	5	eg	eg	NOUN
admet-579	253	6	,	,	PUNCT
admet-579	253	7	inulin	inulin	NOUN
admet-579	253	8	)	)	PUNCT
admet-579	253	9	or	or	CCONJ
admet-579	253	10	higher	high	ADJ
admet-579	253	11	albumin	albumin	ADJ
admet-579	253	12	binding	bind	VERB
admet-579	253	13	affinity	affinity	NOUN
admet-579	253	14	(	(	PUNCT
admet-579	253	15	eg	eg	NOUN
admet-579	253	16	,	,	PUNCT
admet-579	253	17	dicloxacillin	dicloxacillin	PROPN
admet-579	253	18	)	)	PUNCT
admet-579	253	19	,	,	PUNCT
admet-579	253	20	there	there	PRON
admet-579	253	21	may	may	AUX
admet-579	253	22	be	be	AUX
admet-579	253	23	significant	significant	ADJ
admet-579	253	24	permeability	permeability	NOUN
admet-579	253	25	limitation	limitation	NOUN
admet-579	253	26	that	that	PRON
admet-579	253	27	can	can	AUX
admet-579	253	28	be	be	AUX
admet-579	253	29	modeled	model	VERB
admet-579	253	30	by	by	ADP
admet-579	253	31	treating	treat	VERB
admet-579	253	32	the	the	DET
admet-579	253	33	pkquest	pkqu	ADJ
admet-579	253	34	capillary	capillary	ADJ
admet-579	253	35	permeability	permeability	NOUN
admet-579	253	36	parameter	parameter	NOUN
admet-579	253	37	“	"	PUNCT
admet-579	253	38	fclr	fclr	NOUN
admet-579	253	39	”	"	PUNCT
admet-579	253	40	as	as	ADP
admet-579	253	41	an	an	DET
admet-579	253	42	additional	additional	ADJ
admet-579	253	43	adjustable	adjustable	ADJ
admet-579	253	44	parameter	parameter	NOUN
admet-579	253	45	.	.	PUNCT
admet-579	254	1	conclusion	conclusion	NOUN
admet-579	254	2	it	it	PRON
admet-579	254	3	is	be	AUX
admet-579	254	4	clear	clear	ADJ
admet-579	254	5	from	from	ADP
admet-579	254	6	the	the	DET
admet-579	254	7	above	above	ADJ
admet-579	254	8	discussion	discussion	NOUN
admet-579	254	9	that	that	SCONJ
admet-579	254	10	the	the	DET
admet-579	254	11	hls	hls	NOUN
admet-579	254	12	and	and	CCONJ
admet-579	254	13	ecs	ecs	PROPN
admet-579	254	14	represent	represent	VERB
admet-579	254	15	the	the	DET
admet-579	254	16	ideal	ideal	ADJ
admet-579	254	17	solutes	solute	NOUN
admet-579	254	18	for	for	ADP
admet-579	254	19	pbpk	pbpk	NOUN
admet-579	254	20	analysis	analysis	NOUN
admet-579	254	21	.	.	PUNCT
admet-579	255	1	the	the	DET
admet-579	255	2	pk	pk	NOUN
admet-579	255	3	of	of	ADP
admet-579	255	4	these	these	DET
admet-579	255	5	solutes	solute	NOUN
admet-579	255	6	can	can	AUX
admet-579	255	7	usually	usually	ADV
admet-579	255	8	be	be	AUX
admet-579	255	9	accurately	accurately	ADV
admet-579	255	10	predicted	predict	VERB
admet-579	255	11	using	use	VERB
admet-579	255	12	only	only	ADV
admet-579	255	13	zero	zero	NUM
admet-579	255	14	(	(	PUNCT
admet-579	255	15	volatile	volatile	ADJ
admet-579	255	16	anesthetics	anesthetic	NOUN
admet-579	255	17	)	)	PUNCT
admet-579	255	18	or	or	CCONJ
admet-579	255	19	one	one	NUM
admet-579	255	20	adjustable	adjustable	ADJ
admet-579	255	21	parameter	parameter	NOUN
admet-579	255	22	(	(	PUNCT
admet-579	255	23	the	the	DET
admet-579	255	24	clearance	clearance	NOUN
admet-579	255	25	)	)	PUNCT
admet-579	255	26	.	.	PUNCT
admet-579	256	1	not	not	PART
admet-579	256	2	only	only	ADV
admet-579	256	3	can	can	AUX
admet-579	256	4	one	one	NUM
admet-579	256	5	predict	predict	VERB
admet-579	256	6	the	the	DET
admet-579	256	7	blood	blood	NOUN
admet-579	256	8	or	or	CCONJ
admet-579	256	9	plasma	plasma	NOUN
admet-579	256	10	pk	pk	NOUN
admet-579	256	11	,	,	PUNCT
admet-579	256	12	but	but	CCONJ
admet-579	256	13	having	have	VERB
admet-579	256	14	so	so	ADV
admet-579	256	15	few	few	ADJ
admet-579	256	16	adjustable	adjustable	ADJ
admet-579	256	17	parameters	parameter	NOUN
admet-579	256	18	increases	increase	VERB
admet-579	256	19	ones	one	NOUN
admet-579	256	20	confidence	confidence	NOUN
admet-579	256	21	in	in	ADP
admet-579	256	22	the	the	DET
admet-579	256	23	pbpk	pbpk	ADJ
admet-579	256	24	model	model	NOUN
admet-579	256	25	,	,	PUNCT
admet-579	256	26	allowing	allow	VERB
admet-579	256	27	the	the	DET
admet-579	256	28	determination	determination	NOUN
admet-579	256	29	of	of	ADP
admet-579	256	30	the	the	DET
admet-579	256	31	time	time	NOUN
admet-579	256	32	dependent	dependent	ADJ
admet-579	256	33	concentration	concentration	NOUN
admet-579	256	34	in	in	ADP
admet-579	256	35	the	the	DET
admet-579	256	36	different	different	ADJ
admet-579	256	37	tissues	tissue	NOUN
admet-579	256	38	and	and	CCONJ
admet-579	256	39	how	how	SCONJ
admet-579	256	40	the	the	DET
admet-579	256	41	pk	pk	NOUN
admet-579	256	42	varies	vary	VERB
admet-579	256	43	with	with	ADP
admet-579	256	44	,	,	PUNCT
admet-579	256	45	eg	eg	NOUN
admet-579	256	46	,	,	PUNCT
admet-579	256	47	exercise	exercise	NOUN
admet-579	256	48	or	or	CCONJ
admet-579	256	49	body	body	NOUN
admet-579	256	50	fat	fat	ADJ
admet-579	256	51	fraction	fraction	NOUN
admet-579	256	52	.	.	PUNCT
admet-579	257	1	unfortunately	unfortunately	ADV
admet-579	257	2	,	,	PUNCT
admet-579	257	3	the	the	DET
admet-579	257	4	hls	hls	NOUN
admet-579	257	5	and	and	CCONJ
admet-579	257	6	ecs	ecs	PROPN
admet-579	257	7	solutes	solute	NOUN
admet-579	257	8	classes	class	NOUN
admet-579	257	9	are	be	AUX
admet-579	257	10	limited	limit	VERB
admet-579	257	11	,	,	PUNCT
admet-579	257	12	with	with	ADP
admet-579	257	13	the	the	DET
admet-579	257	14	examples	example	NOUN
admet-579	257	15	discussed	discuss	VERB
admet-579	257	16	above	above	ADP
admet-579	257	17	nearly	nearly	ADV
admet-579	257	18	exhausting	exhaust	VERB
admet-579	257	19	the	the	DET
admet-579	257	20	important	important	ADJ
admet-579	257	21	drug	drug	NOUN
admet-579	257	22	classes	class	NOUN
admet-579	257	23	.	.	PUNCT
admet-579	258	1	in	in	ADP
admet-579	258	2	contrast	contrast	NOUN
admet-579	258	3	,	,	PUNCT
admet-579	258	4	for	for	ADP
admet-579	258	5	the	the	DET
admet-579	258	6	much	much	ADV
admet-579	258	7	more	more	ADV
admet-579	258	8	common	common	ADJ
admet-579	258	9	weak	weak	ADJ
admet-579	258	10	acid	acid	NOUN
admet-579	258	11	or	or	CCONJ
admet-579	258	12	base	base	NOUN
admet-579	258	13	solutes	solute	NOUN
admet-579	258	14	,	,	PUNCT
admet-579	258	15	an	an	DET
admet-579	258	16	accurate	accurate	ADJ
admet-579	258	17	pbpk	pbpk	ADJ
admet-579	258	18	model	model	NOUN
admet-579	258	19	requires	require	VERB
admet-579	258	20	detailed	detailed	ADJ
admet-579	258	21	animal	animal	NOUN
admet-579	258	22	experimental	experimental	ADJ
admet-579	258	23	measurement	measurement	NOUN
admet-579	258	24	of	of	ADP
admet-579	258	25	the	the	DET
admet-579	258	26	individual	individual	ADJ
admet-579	258	27	organ	organ	NOUN
admet-579	258	28	ki	ki	PROPN
admet-579	258	29	,	,	PUNCT
admet-579	258	30	and	and	CCONJ
admet-579	258	31	then	then	ADV
admet-579	258	32	an	an	DET
admet-579	258	33	uncertain	uncertain	ADJ
admet-579	258	34	extrapolation	extrapolation	NOUN
admet-579	258	35	to	to	ADP
admet-579	258	36	the	the	DET
admet-579	258	37	human	human	NOUN
admet-579	258	38	.	.	PUNCT
admet-579	259	1	these	these	DET
admet-579	259	2	factors	factor	NOUN
admet-579	259	3	have	have	AUX
admet-579	259	4	significantly	significantly	ADV
admet-579	259	5	limited	limit	VERB
admet-579	259	6	the	the	DET
admet-579	259	7	confidence	confidence	NOUN
admet-579	259	8	in	in	ADP
admet-579	259	9	the	the	DET
admet-579	259	10	use	use	NOUN
admet-579	259	11	of	of	ADP
admet-579	259	12	pbpk	pbpk	NOUN
admet-579	259	13	models	model	NOUN
admet-579	259	14	for	for	ADP
admet-579	259	15	,	,	PUNCT
admet-579	259	16	eg	eg	NOUN
admet-579	259	17	,	,	PUNCT
admet-579	259	18	toxicological	toxicological	ADJ
admet-579	259	19	applications	application	NOUN
admet-579	259	20	[	[	X
admet-579	259	21	23	23	NUM
admet-579	259	22	]	]	PUNCT
admet-579	259	23	.	.	PUNCT
admet-579	260	1	it	it	PRON
admet-579	260	2	does	do	AUX
admet-579	260	3	not	not	PART
admet-579	260	4	seem	seem	VERB
admet-579	260	5	to	to	PART
admet-579	260	6	be	be	AUX
admet-579	260	7	widely	widely	ADV
admet-579	260	8	recognized	recognize	VERB
admet-579	260	9	that	that	SCONJ
admet-579	260	10	the	the	DET
admet-579	260	11	hls	hls	NOUN
admet-579	260	12	and	and	CCONJ
admet-579	260	13	ecs	ecs	PROPN
admet-579	260	14	solutes	solute	NOUN
admet-579	260	15	are	be	AUX
admet-579	260	16	important	important	ADJ
admet-579	260	17	exceptions	exception	NOUN
admet-579	260	18	to	to	ADP
admet-579	260	19	the	the	DET
admet-579	260	20	usual	usual	ADJ
admet-579	260	21	problems	problem	NOUN
admet-579	260	22	associated	associate	VERB
admet-579	260	23	with	with	ADP
admet-579	260	24	pbpk	pbpk	ADJ
admet-579	260	25	analysis	analysis	NOUN
admet-579	260	26	and	and	CCONJ
admet-579	260	27	it	it	PRON
admet-579	260	28	is	be	AUX
admet-579	260	29	hoped	hope	VERB
admet-579	260	30	that	that	SCONJ
admet-579	260	31	this	this	DET
admet-579	260	32	discussion	discussion	NOUN
admet-579	260	33	will	will	AUX
admet-579	260	34	remedy	remedy	VERB
admet-579	260	35	this	this	PRON
admet-579	260	36	.	.	PUNCT
admet-579	261	1	this	this	DET
admet-579	261	2	discussion	discussion	NOUN
admet-579	261	3	has	have	AUX
admet-579	261	4	focused	focus	VERB
admet-579	261	5	on	on	ADP
admet-579	261	6	only	only	ADV
admet-579	261	7	one	one	NUM
admet-579	261	8	aspect	aspect	NOUN
admet-579	261	9	of	of	ADP
admet-579	261	10	pkquest	pkquest	NOUN
admet-579	261	11	:	:	PUNCT
admet-579	261	12	the	the	DET
admet-579	261	13	pbpk	pbpk	ADJ
admet-579	261	14	analysis	analysis	NOUN
admet-579	261	15	of	of	ADP
admet-579	261	16	the	the	DET
admet-579	261	17	hls	hls	NOUN
admet-579	261	18	and	and	CCONJ
admet-579	261	19	ecs	ecs	PROPN
admet-579	261	20	solutes	solute	NOUN
admet-579	261	21	.	.	PUNCT
admet-579	262	1	pkquest	pkquest	PROPN
admet-579	262	2	also	also	ADV
admet-579	262	3	offers	offer	VERB
admet-579	262	4	several	several	ADJ
admet-579	262	5	other	other	ADJ
admet-579	262	6	novel	novel	ADJ
admet-579	262	7	pbpk	pbpk	NOUN
admet-579	262	8	features	feature	NOUN
admet-579	262	9	,	,	PUNCT
admet-579	262	10	including	include	VERB
admet-579	262	11	:	:	PUNCT
admet-579	262	12	1	1	X
admet-579	262	13	)	)	PUNCT
admet-579	262	14	the	the	DET
admet-579	262	15	first	first	ADJ
admet-579	262	16	incorporation	incorporation	NOUN
admet-579	262	17	of	of	ADP
admet-579	262	18	the	the	DET
admet-579	262	19	use	use	NOUN
admet-579	262	20	of	of	ADP
admet-579	262	21	antecubital	antecubital	ADJ
admet-579	262	22	vein	vein	NOUN
admet-579	262	23	sampling	sample	VERB
admet-579	262	24	in	in	ADP
admet-579	262	25	a	a	DET
admet-579	262	26	pbpk	pbpk	ADJ
admet-579	262	27	model	model	NOUN
admet-579	263	1	[	[	X
admet-579	263	2	9	9	NUM
admet-579	263	3	]	]	PUNCT
admet-579	263	4	;	;	PUNCT
admet-579	263	5	and	and	CCONJ
admet-579	263	6	2	2	X
admet-579	263	7	)	)	PUNCT
admet-579	263	8	the	the	DET
admet-579	263	9	first	first	ADJ
admet-579	263	10	ethanol	ethanol	NOUN
admet-579	263	11	pbpk	pbpk	NOUN
admet-579	263	12	model	model	NOUN
admet-579	263	13	with	with	ADP
admet-579	263	14	a	a	DET
admet-579	263	15	rigorous	rigorous	ADJ
admet-579	263	16	definition	definition	NOUN
admet-579	263	17	of	of	ADP
admet-579	263	18	the	the	DET
admet-579	263	19	non	non	ADJ
admet-579	263	20	-	-	ADJ
admet-579	263	21	linear	linear	ADJ
admet-579	263	22	bioavailability	bioavailability	NOUN
admet-579	263	23	[	[	X
admet-579	263	24	6	6	NUM
admet-579	263	25	]	]	PUNCT
admet-579	263	26	.	.	PUNCT
admet-579	264	1	in	in	ADP
admet-579	264	2	addition	addition	NOUN
admet-579	264	3	to	to	ADP
admet-579	264	4	the	the	DET
admet-579	264	5	pbpk	pbpk	PROPN
admet-579	264	6	module	module	NOUN
admet-579	264	7	,	,	PUNCT
admet-579	264	8	pkquest	pkquest	NOUN
admet-579	264	9	also	also	ADV
admet-579	264	10	has	have	VERB
admet-579	264	11	a	a	DET
admet-579	264	12	number	number	NOUN
admet-579	264	13	of	of	ADP
admet-579	264	14	other	other	ADJ
admet-579	264	15	pk	pk	NOUN
admet-579	264	16	features	feature	NOUN
admet-579	264	17	.	.	PUNCT
admet-579	265	1	there	there	PRON
admet-579	265	2	is	be	VERB
admet-579	265	3	major	major	ADJ
admet-579	265	4	emphasis	emphasis	NOUN
admet-579	265	5	on	on	ADP
admet-579	265	6	deconvolution	deconvolution	NOUN
admet-579	265	7	which	which	PRON
admet-579	265	8	is	be	AUX
admet-579	265	9	a	a	DET
admet-579	265	10	powerful	powerful	ADJ
admet-579	265	11	and	and	CCONJ
admet-579	265	12	underutilized	underutilized	ADJ
admet-579	265	13	modeling	modeling	NOUN
admet-579	265	14	approach	approach	NOUN
admet-579	265	15	.	.	PUNCT
admet-579	266	1	there	there	PRON
admet-579	266	2	are	be	VERB
admet-579	266	3	6	6	NUM
admet-579	266	4	different	different	ADJ
admet-579	266	5	deconvolution	deconvolution	NOUN
admet-579	266	6	routines	routine	NOUN
admet-579	266	7	available	available	ADJ
admet-579	266	8	,	,	PUNCT
admet-579	266	9	each	each	PRON
admet-579	266	10	with	with	ADP
admet-579	266	11	its	its	PRON
admet-579	266	12	strengths	strength	NOUN
admet-579	266	13	and	and	CCONJ
admet-579	266	14	limitations	limitation	NOUN
admet-579	266	15	.	.	PUNCT
admet-579	267	1	one	one	NUM
admet-579	267	2	novel	novel	ADJ
admet-579	267	3	deconvolution	deconvolution	NOUN
admet-579	267	4	application	application	NOUN
admet-579	267	5	is	be	AUX
admet-579	267	6	a	a	DET
admet-579	267	7	general	general	ADJ
admet-579	267	8	approach	approach	NOUN
admet-579	267	9	to	to	PART
admet-579	267	10	determine	determine	VERB
admet-579	267	11	the	the	DET
admet-579	267	12	intestinal	intestinal	ADJ
admet-579	267	13	permeability	permeability	NOUN
admet-579	267	14	during	during	ADP
admet-579	267	15	normal	normal	ADJ
admet-579	267	16	human	human	ADJ
admet-579	267	17	drug	drug	NOUN
admet-579	267	18	absorption	absorption	NOUN
admet-579	267	19	,	,	PUNCT
admet-579	267	20	with	with	ADP
admet-579	267	21	application	application	NOUN
admet-579	267	22	of	of	ADP
admet-579	267	23	this	this	DET
admet-579	267	24	approach	approach	NOUN
admet-579	267	25	to	to	ADP
admet-579	267	26	90	90	NUM
admet-579	267	27	different	different	ADJ
admet-579	267	28	drugs	drug	NOUN
admet-579	267	29	[	[	X
admet-579	267	30	13	13	NUM
admet-579	267	31	]	]	PUNCT
admet-579	267	32	.	.	PUNCT
admet-579	268	1	all	all	PRON
admet-579	268	2	of	of	ADP
admet-579	268	3	these	these	DET
admet-579	268	4	features	feature	NOUN
admet-579	268	5	are	be	AUX
admet-579	268	6	discussed	discuss	VERB
admet-579	268	7	with	with	ADP
admet-579	268	8	detailed	detailed	ADJ
admet-579	268	9	worked	work	VERB
admet-579	268	10	examples	example	NOUN
admet-579	268	11	in	in	ADP
admet-579	268	12	the	the	DET
admet-579	268	13	freely	freely	ADV
admet-579	268	14	distributed	distribute	VERB
admet-579	268	15	textbook	textbook	NOUN
admet-579	268	16	“	"	PUNCT
admet-579	268	17	computer	computer	NOUN
admet-579	268	18	assisted	assist	VERB
admet-579	268	19	human	human	ADJ
admet-579	268	20	pharmacokinetics	pharmacokinetic	NOUN
admet-579	268	21	”	"	PUNCT
admet-579	269	1	[	[	X
admet-579	269	2	1	1	NUM
admet-579	269	3	]	]	PUNCT
admet-579	269	4	.	.	PUNCT
admet-579	270	1	it	it	PRON
admet-579	270	2	is	be	AUX
admet-579	270	3	hoped	hope	VERB
admet-579	270	4	that	that	SCONJ
admet-579	270	5	the	the	DET
admet-579	270	6	interested	interested	ADJ
admet-579	270	7	reader	reader	NOUN
admet-579	270	8	will	will	AUX
admet-579	270	9	download	download	VERB
admet-579	270	10	the	the	DET
admet-579	270	11	free	free	ADJ
admet-579	270	12	software	software	NOUN
admet-579	270	13	and	and	CCONJ
admet-579	270	14	textbook	textbook	NOUN
admet-579	270	15	from	from	ADP
admet-579	270	16	www.pkquest.com	www.pkquest.com	NOUN
admet-579	270	17	and	and	CCONJ
admet-579	270	18	try	try	VERB
admet-579	270	19	out	out	ADP
admet-579	270	20	these	these	DET
admet-579	270	21	and	and	CCONJ
admet-579	270	22	other	other	ADJ
admet-579	270	23	pkquest	pkqu	ADJ
admet-579	270	24	pk	pk	NOUN
admet-579	270	25	features	feature	NOUN
admet-579	270	26	.	.	PUNCT
admet-579	271	1	references	reference	NOUN
admet-579	271	2	[	[	X
admet-579	271	3	1	1	NUM
admet-579	271	4	]	]	X
admet-579	271	5	d.g	d.g	PROPN
admet-579	271	6	.	.	PROPN
admet-579	271	7	levitt	levitt	PROPN
admet-579	271	8	.	.	PUNCT
admet-579	272	1	computer	computer	NOUN
admet-579	272	2	assisted	assist	VERB
admet-579	272	3	human	human	ADJ
admet-579	272	4	pharmacokinetics	pharmacokinetic	NOUN
admet-579	272	5	:	:	PUNCT
admet-579	272	6	non	non	ADJ
admet-579	272	7	-	-	ADJ
admet-579	272	8	compartmental	compartmental	ADJ
admet-579	272	9	,	,	PUNCT
admet-579	272	10	deconvolution	deconvolution	NOUN
admet-579	272	11	,	,	PUNCT
admet-579	272	12	physiologically	physiologically	ADV
admet-579	272	13	based	base	VERB
admet-579	272	14	,	,	PUNCT
admet-579	272	15	intestinal	intestinal	ADJ
admet-579	272	16	absorption	absorption	NOUN
admet-579	272	17	,	,	PUNCT
admet-579	272	18	non	non	ADJ
admet-579	272	19	-	-	ADJ
admet-579	272	20	linear	linear	ADJ
admet-579	272	21	;	;	PUNCT
admet-579	272	22	www.pkquest.com	www.pkquest.com	X
admet-579	272	23	.	.	NOUN
admet-579	272	24	2017	2017	NUM
admet-579	272	25	.	.	PUNCT
admet-579	273	1	[	[	X
admet-579	273	2	2	2	NUM
admet-579	273	3	]	]	PUNCT
admet-579	273	4	p.	p.	NOUN
admet-579	273	5	poulin	poulin	PROPN
admet-579	273	6	.	.	PUNCT
admet-579	274	1	a	a	DET
admet-579	274	2	paradigm	paradigm	NOUN
admet-579	274	3	shift	shift	NOUN
admet-579	274	4	in	in	ADP
admet-579	274	5	pharmacokinetic	pharmacokinetic	NOUN
admet-579	274	6	-	-	PUNCT
admet-579	274	7	pharmacodynamic	pharmacodynamic	ADJ
admet-579	274	8	(	(	PUNCT
admet-579	274	9	pkpd	pkpd	PROPN
admet-579	274	10	)	)	PUNCT
admet-579	274	11	modeling	modeling	NOUN
admet-579	274	12	:	:	PUNCT
admet-579	274	13	rule	rule	NOUN
admet-579	274	14	of	of	ADP
admet-579	274	15	thumb	thumb	NOUN
admet-579	274	16	for	for	ADP
admet-579	274	17	estimating	estimate	VERB
admet-579	274	18	free	free	ADJ
admet-579	274	19	drug	drug	NOUN
admet-579	274	20	level	level	NOUN
admet-579	274	21	in	in	ADP
admet-579	274	22	tissue	tissue	NOUN
admet-579	274	23	compared	compare	VERB
admet-579	274	24	with	with	ADP
admet-579	274	25	plasma	plasma	NOUN
admet-579	274	26	to	to	PART
admet-579	274	27	guide	guide	VERB
admet-579	274	28	drug	drug	NOUN
admet-579	274	29	design	design	NOUN
admet-579	274	30	.	.	PUNCT
admet-579	275	1	j	j	PROPN
admet-579	275	2	pharm	pharm	PROPN
admet-579	275	3	sci	sci	PROPN
admet-579	275	4	104	104	NUM
admet-579	275	5	(	(	PUNCT
admet-579	275	6	2015	2015	NUM
admet-579	275	7	)	)	PUNCT
admet-579	275	8	2359	2359	NUM
admet-579	275	9	-	-	SYM
admet-579	275	10	2368	2368	NUM
admet-579	275	11	.	.	PUNCT
admet-579	276	1	[	[	X
admet-579	276	2	3	3	X
admet-579	276	3	]	]	X
admet-579	276	4	d.g	d.g	PROPN
admet-579	276	5	.	.	PROPN
admet-579	276	6	levitt	levitt	PROPN
admet-579	276	7	.	.	PUNCT
admet-579	277	1	pkquest	pkquest	PROPN
admet-579	277	2	:	:	PUNCT
admet-579	278	1	a	a	DET
admet-579	278	2	general	general	ADJ
admet-579	278	3	physiologically	physiologically	ADV
admet-579	278	4	based	base	VERB
admet-579	278	5	pharmacokinetic	pharmacokinetic	ADJ
admet-579	278	6	model	model	NOUN
admet-579	278	7	.	.	PUNCT
admet-579	279	1	introduction	introduction	NOUN
admet-579	279	2	and	and	CCONJ
admet-579	279	3	application	application	NOUN
admet-579	279	4	to	to	ADP
admet-579	279	5	propranolol	propranolol	NOUN
admet-579	279	6	.	.	PUNCT
admet-579	280	1	bmc	bmc	PROPN
admet-579	280	2	clin	clin	PROPN
admet-579	280	3	pharmacol	pharmacol	PROPN
admet-579	280	4	2	2	NUM
admet-579	280	5	(	(	PUNCT
admet-579	280	6	2002	2002	NUM
admet-579	280	7	)	)	PUNCT
admet-579	280	8	5	5	NUM
admet-579	280	9	.	.	PUNCT
admet-579	281	1	[	[	X
admet-579	281	2	4	4	X
admet-579	281	3	]	]	X
admet-579	281	4	d.g	d.g	PROPN
admet-579	281	5	.	.	PROPN
admet-579	281	6	levitt	levitt	PROPN
admet-579	281	7	.	.	PUNCT
admet-579	282	1	pkquest	pkquest	NOUN
admet-579	282	2	:	:	PUNCT
admet-579	283	1	capillary	capillary	ADJ
admet-579	283	2	permeability	permeability	NOUN
admet-579	283	3	limitation	limitation	NOUN
admet-579	283	4	and	and	CCONJ
admet-579	283	5	plasma	plasma	NOUN
admet-579	283	6	protein	protein	NOUN
admet-579	283	7	binding	bind	VERB
admet-579	283	8	application	application	NOUN
admet-579	283	9	to	to	ADP
admet-579	283	10	human	human	ADJ
admet-579	283	11	inulin	inulin	NOUN
admet-579	283	12	,	,	PUNCT
admet-579	283	13	dicloxacillin	dicloxacillin	NOUN
admet-579	283	14	and	and	CCONJ
admet-579	283	15	ceftriaxone	ceftriaxone	NOUN
admet-579	283	16	pharmacokinetics	pharmacokinetic	NOUN
admet-579	283	17	.	.	PUNCT
admet-579	284	1	bmc	bmc	PROPN
admet-579	284	2	clin	clin	PROPN
admet-579	284	3	pharmacol	pharmacol	PROPN
admet-579	284	4	2	2	NUM
admet-579	284	5	(	(	PUNCT
admet-579	284	6	2002	2002	NUM
admet-579	284	7	)	)	PUNCT
admet-579	284	8	7	7	NUM
admet-579	284	9	.	.	PUNCT
admet-579	285	1	[	[	X
admet-579	285	2	5	5	NUM
admet-579	285	3	]	]	X
admet-579	285	4	d.g	d.g	PROPN
admet-579	285	5	.	.	PROPN
admet-579	285	6	levitt	levitt	PROPN
admet-579	285	7	.	.	PUNCT
admet-579	286	1	pkquest	pkquest	NOUN
admet-579	286	2	:	:	PUNCT
admet-579	287	1	volatile	volatile	ADJ
admet-579	287	2	solutes	solute	VERB
admet-579	287	3	application	application	NOUN
admet-579	287	4	to	to	ADP
admet-579	287	5	enflurane	enflurane	NOUN
admet-579	287	6	,	,	PUNCT
admet-579	287	7	nitrous	nitrous	ADJ
admet-579	287	8	oxide	oxide	NOUN
admet-579	287	9	,	,	PUNCT
admet-579	287	10	halothane	halothane	NOUN
admet-579	287	11	,	,	PUNCT
admet-579	287	12	methoxyflurane	methoxyflurane	NOUN
admet-579	287	13	and	and	CCONJ
admet-579	287	14	toluene	toluene	NOUN
admet-579	287	15	pharmacokinetics	pharmacokinetic	NOUN
admet-579	287	16	.	.	PUNCT
admet-579	288	1	bmc	bmc	ADJ
admet-579	288	2	anesthesiol	anesthesiol	NOUN
admet-579	288	3	2	2	NUM
admet-579	288	4	(	(	PUNCT
admet-579	288	5	2002	2002	NUM
admet-579	288	6	)	)	PUNCT
admet-579	288	7	5	5	NUM
admet-579	288	8	.	.	PUNCT
admet-579	289	1	[	[	X
admet-579	289	2	6	6	NUM
admet-579	289	3	]	]	X
admet-579	289	4	d.g	d.g	PROPN
admet-579	289	5	.	.	PROPN
admet-579	289	6	levitt	levitt	PROPN
admet-579	289	7	.	.	PUNCT
admet-579	290	1	pkquest	pkquest	PROPN
admet-579	290	2	:	:	PUNCT
admet-579	291	1	measurement	measurement	NOUN
admet-579	291	2	of	of	ADP
admet-579	291	3	intestinal	intestinal	ADJ
admet-579	291	4	absorption	absorption	NOUN
admet-579	291	5	and	and	CCONJ
admet-579	291	6	first	first	ADV
admet-579	291	7	pass	pass	VERB
admet-579	291	8	metabolism	metabolism	NOUN
admet-579	291	9	application	application	NOUN
admet-579	291	10	to	to	ADP
admet-579	291	11	human	human	ADJ
admet-579	291	12	ethanol	ethanol	NOUN
admet-579	291	13	pharmacokinetics	pharmacokinetic	NOUN
admet-579	291	14	.	.	PUNCT
admet-579	292	1	bmc	bmc	PROPN
admet-579	292	2	clin	clin	PROPN
admet-579	292	3	pharmacol	pharmacol	PROPN
admet-579	292	4	2	2	NUM
admet-579	292	5	(	(	PUNCT
admet-579	292	6	2002	2002	NUM
admet-579	292	7	)	)	PUNCT
admet-579	292	8	4	4	NUM
admet-579	292	9	.	.	NOUN
admet-579	292	10	http://www.pkquest.com/	http://www.pkquest.com/	NOUN
admet-579	292	11	http://www.pkquest.com/	http://www.pkquest.com/	PROPN
admet-579	292	12	admet	admet	PROPN
admet-579	292	13	&	&	CCONJ
admet-579	292	14	dmpk	dmpk	PROPN
admet-579	292	15	7(1	7(1	PROPN
admet-579	292	16	)	)	PUNCT
admet-579	292	17	(	(	PUNCT
admet-579	292	18	2019	2019	NUM
admet-579	292	19	)	)	PUNCT
admet-579	292	20	60	60	NUM
admet-579	292	21	-	-	SYM
admet-579	292	22	75	75	NUM
admet-579	292	23	lipid	lipid	NOUN
admet-579	292	24	soluble	soluble	ADJ
admet-579	292	25	and	and	CCONJ
admet-579	292	26	extracellular	extracellular	ADJ
admet-579	292	27	solutes	solute	NOUN
admet-579	292	28	doi	doi	NOUN
admet-579	292	29	:	:	PUNCT
admet-579	292	30	10.5599	10.5599	NUM
admet-579	292	31	/	/	SYM
admet-579	292	32	admet.579	admet.579	NOUN
admet-579	292	33	75	75	NUM
admet-579	292	34	[	[	NOUN
admet-579	292	35	7	7	NUM
admet-579	292	36	]	]	X
admet-579	292	37	d.g	d.g	PROPN
admet-579	292	38	.	.	PROPN
admet-579	292	39	levitt	levitt	PROPN
admet-579	292	40	.	.	PUNCT
admet-579	293	1	the	the	DET
admet-579	293	2	pharmacokinetics	pharmacokinetic	NOUN
admet-579	293	3	of	of	ADP
admet-579	293	4	the	the	DET
admet-579	293	5	interstitial	interstitial	ADJ
admet-579	293	6	space	space	NOUN
admet-579	293	7	in	in	ADP
admet-579	293	8	humans	human	NOUN
admet-579	293	9	.	.	PUNCT
admet-579	294	1	bmc	bmc	PROPN
admet-579	294	2	clin	clin	PROPN
admet-579	294	3	pharmacol	pharmacol	PROPN
admet-579	294	4	3	3	NUM
admet-579	294	5	(	(	PUNCT
admet-579	294	6	2003	2003	NUM
admet-579	294	7	)	)	PUNCT
admet-579	294	8	3	3	X
admet-579	294	9	.	.	PUNCT
admet-579	295	1	[	[	X
admet-579	295	2	8	8	NUM
admet-579	295	3	]	]	X
admet-579	295	4	d.g	d.g	PROPN
admet-579	295	5	.	.	PROPN
admet-579	295	6	levitt	levitt	PROPN
admet-579	295	7	.	.	PUNCT
admet-579	296	1	the	the	DET
admet-579	296	2	use	use	NOUN
admet-579	296	3	of	of	ADP
admet-579	296	4	a	a	DET
admet-579	296	5	physiologically	physiologically	ADV
admet-579	296	6	based	base	VERB
admet-579	296	7	pharmacokinetic	pharmacokinetic	ADJ
admet-579	296	8	model	model	NOUN
admet-579	296	9	to	to	PART
admet-579	296	10	evaluate	evaluate	VERB
admet-579	296	11	deconvolution	deconvolution	NOUN
admet-579	296	12	measurements	measurement	NOUN
admet-579	296	13	of	of	ADP
admet-579	296	14	systemic	systemic	ADJ
admet-579	296	15	absorption	absorption	NOUN
admet-579	296	16	.	.	PUNCT
admet-579	297	1	bmc	bmc	PROPN
admet-579	297	2	clin	clin	PROPN
admet-579	297	3	pharmacol	pharmacol	PROPN
admet-579	297	4	3	3	NUM
admet-579	297	5	(	(	PUNCT
admet-579	297	6	2003	2003	NUM
admet-579	297	7	)	)	PUNCT
admet-579	297	8	1	1	NUM
admet-579	297	9	.	.	PUNCT
admet-579	298	1	[	[	X
admet-579	298	2	9	9	NUM
admet-579	298	3	]	]	X
admet-579	298	4	d.g	d.g	PROPN
admet-579	298	5	.	.	PROPN
admet-579	298	6	levitt	levitt	PROPN
admet-579	298	7	.	.	PUNCT
admet-579	299	1	physiologically	physiologically	ADV
admet-579	299	2	based	base	VERB
admet-579	299	3	pharmacokinetic	pharmacokinetic	ADJ
admet-579	299	4	modeling	modeling	NOUN
admet-579	299	5	of	of	ADP
admet-579	299	6	arterial	arterial	ADJ
admet-579	299	7	antecubital	antecubital	ADJ
admet-579	299	8	vein	vein	ADJ
admet-579	299	9	concentration	concentration	NOUN
admet-579	299	10	difference	difference	NOUN
admet-579	299	11	.	.	PUNCT
admet-579	300	1	bmc	bmc	PROPN
admet-579	300	2	clin	clin	PROPN
admet-579	300	3	pharmacol	pharmacol	PROPN
admet-579	300	4	4	4	NUM
admet-579	300	5	(	(	PUNCT
admet-579	300	6	2004	2004	NUM
admet-579	300	7	)	)	PUNCT
admet-579	300	8	2	2	NUM
admet-579	300	9	.	.	PUNCT
admet-579	301	1	[	[	X
admet-579	301	2	10	10	NUM
admet-579	301	3	]	]	X
admet-579	301	4	d.g	d.g	PROPN
admet-579	301	5	.	.	PROPN
admet-579	301	6	levitt	levitt	PROPN
admet-579	301	7	.	.	PUNCT
admet-579	302	1	heterogeneity	heterogeneity	NOUN
admet-579	302	2	of	of	ADP
admet-579	302	3	human	human	ADJ
admet-579	302	4	adipose	adipose	ADJ
admet-579	302	5	blood	blood	NOUN
admet-579	302	6	flow	flow	NOUN
admet-579	302	7	.	.	PUNCT
admet-579	303	1	bmc	bmc	PROPN
admet-579	303	2	clin	clin	PROPN
admet-579	303	3	pharmacol	pharmacol	PROPN
admet-579	303	4	7	7	NUM
admet-579	303	5	(	(	PUNCT
admet-579	303	6	2007	2007	NUM
admet-579	303	7	)	)	PUNCT
admet-579	303	8	1	1	NUM
admet-579	303	9	.	.	PUNCT
admet-579	304	1	[	[	X
admet-579	304	2	11	11	NUM
admet-579	304	3	]	]	X
admet-579	304	4	d.g	d.g	PROPN
admet-579	304	5	.	.	PROPN
admet-579	304	6	levitt	levitt	PROPN
admet-579	304	7	.	.	PUNCT
admet-579	305	1	pkquest_java	pkquest_java	NOUN
admet-579	305	2	:	:	PUNCT
admet-579	305	3	free	free	ADJ
admet-579	305	4	,	,	PUNCT
admet-579	305	5	interactive	interactive	ADJ
admet-579	305	6	physiologically	physiologically	ADV
admet-579	305	7	based	base	VERB
admet-579	305	8	pharmacokinetic	pharmacokinetic	ADJ
admet-579	305	9	software	software	NOUN
admet-579	305	10	package	package	NOUN
admet-579	305	11	and	and	CCONJ
admet-579	305	12	tutorial	tutorial	NOUN
admet-579	305	13	.	.	PUNCT
admet-579	306	1	bmc	bmc	ADJ
admet-579	306	2	res	re	NOUN
admet-579	306	3	notes	note	NOUN
admet-579	306	4	2	2	NUM
admet-579	306	5	(	(	PUNCT
admet-579	306	6	2009	2009	NUM
admet-579	306	7	)	)	PUNCT
admet-579	306	8	158	158	NUM
admet-579	306	9	.	.	PUNCT
admet-579	307	1	[	[	X
admet-579	307	2	12	12	NUM
admet-579	307	3	]	]	X
admet-579	307	4	d.g	d.g	PROPN
admet-579	307	5	.	.	PROPN
admet-579	307	6	levitt	levitt	PROPN
admet-579	307	7	.	.	PUNCT
admet-579	308	1	quantitative	quantitative	ADJ
admet-579	308	2	relationship	relationship	NOUN
admet-579	308	3	between	between	ADP
admet-579	308	4	the	the	DET
admet-579	308	5	octanol	octanol	NOUN
admet-579	308	6	/	/	SYM
admet-579	308	7	water	water	NOUN
admet-579	308	8	partition	partition	NOUN
admet-579	308	9	coefficient	coefficient	NOUN
admet-579	308	10	and	and	CCONJ
admet-579	308	11	the	the	DET
admet-579	308	12	diffusion	diffusion	NOUN
admet-579	308	13	limitation	limitation	NOUN
admet-579	308	14	of	of	ADP
admet-579	308	15	the	the	DET
admet-579	308	16	exchange	exchange	NOUN
admet-579	308	17	between	between	ADP
admet-579	308	18	adipose	adipose	NOUN
admet-579	308	19	and	and	CCONJ
admet-579	308	20	blood	blood	NOUN
admet-579	308	21	.	.	PUNCT
admet-579	309	1	bmc	bmc	PROPN
admet-579	309	2	clin	clin	PROPN
admet-579	309	3	pharmacol	pharmacol	PROPN
admet-579	309	4	10	10	NUM
admet-579	309	5	(	(	PUNCT
admet-579	309	6	2010	2010	NUM
admet-579	309	7	)	)	PUNCT
admet-579	309	8	1	1	NUM
admet-579	309	9	.	.	PUNCT
admet-579	310	1	[	[	X
admet-579	310	2	13	13	NUM
admet-579	310	3	]	]	X
admet-579	310	4	d.g	d.g	PROPN
admet-579	310	5	.	.	PROPN
admet-579	310	6	levitt	levitt	PROPN
admet-579	310	7	.	.	PUNCT
admet-579	311	1	quantitation	quantitation	NOUN
admet-579	311	2	of	of	ADP
admet-579	311	3	small	small	ADJ
admet-579	311	4	intestinal	intestinal	ADJ
admet-579	311	5	permeability	permeability	NOUN
admet-579	311	6	during	during	ADP
admet-579	311	7	normal	normal	ADJ
admet-579	311	8	human	human	ADJ
admet-579	311	9	drug	drug	NOUN
admet-579	311	10	absorption	absorption	NOUN
admet-579	311	11	.	.	PUNCT
admet-579	312	1	bmc	bmc	PROPN
admet-579	312	2	pharmacol	pharmacol	PROPN
admet-579	312	3	toxicol	toxicol	PROPN
admet-579	312	4	14	14	NUM
admet-579	312	5	(	(	PUNCT
admet-579	312	6	2013	2013	NUM
admet-579	312	7	)	)	PUNCT
admet-579	312	8	34	34	NUM
admet-579	312	9	.	.	PUNCT
admet-579	313	1	[	[	X
admet-579	313	2	14	14	NUM
admet-579	313	3	]	]	X
admet-579	313	4	n.	n.	PROPN
admet-579	313	5	yasuda	yasuda	PROPN
admet-579	313	6	,	,	PUNCT
admet-579	313	7	s.h	s.h	PROPN
admet-579	313	8	.	.	PROPN
admet-579	313	9	lockhart	lockhart	PROPN
admet-579	313	10	,	,	PUNCT
admet-579	313	11	e.i	e.i	PROPN
admet-579	313	12	.	.	PROPN
admet-579	313	13	eger	eger	PROPN
admet-579	313	14	,	,	PUNCT
admet-579	313	15	2nd	2nd	PROPN
admet-579	313	16	,	,	PUNCT
admet-579	313	17	r.b	r.b	PROPN
admet-579	313	18	.	.	PROPN
admet-579	313	19	weiskopf	weiskopf	PROPN
admet-579	313	20	,	,	PUNCT
admet-579	313	21	b.h	b.h	PROPN
admet-579	313	22	.	.	PROPN
admet-579	313	23	johnson	johnson	PROPN
admet-579	313	24	,	,	PUNCT
admet-579	313	25	b.a	b.a	PROPN
admet-579	313	26	.	.	PROPN
admet-579	313	27	freire	freire	PROPN
admet-579	313	28	,	,	PUNCT
admet-579	313	29	a.	a.	NOUN
admet-579	313	30	fassoulaki	fassoulaki	PROPN
admet-579	313	31	.	.	PUNCT
admet-579	314	1	kinetics	kinetic	NOUN
admet-579	314	2	of	of	ADP
admet-579	314	3	desflurane	desflurane	NOUN
admet-579	314	4	,	,	PUNCT
admet-579	314	5	isoflurane	isoflurane	NOUN
admet-579	314	6	,	,	PUNCT
admet-579	314	7	and	and	CCONJ
admet-579	314	8	halothane	halothane	NOUN
admet-579	314	9	in	in	ADP
admet-579	314	10	humans	human	NOUN
admet-579	314	11	.	.	PUNCT
admet-579	315	1	anesthesiology	anesthesiology	NOUN
admet-579	315	2	74	74	NUM
admet-579	315	3	(	(	PUNCT
admet-579	315	4	1991	1991	NUM
admet-579	315	5	)	)	PUNCT
admet-579	315	6	489	489	NUM
admet-579	315	7	-	-	PUNCT
admet-579	315	8	498	498	NUM
admet-579	315	9	.	.	PUNCT
admet-579	316	1	[	[	X
admet-579	316	2	15	15	NUM
admet-579	316	3	]	]	X
admet-579	316	4	n.	n.	PROPN
admet-579	316	5	yasuda	yasuda	PROPN
admet-579	316	6	,	,	PUNCT
admet-579	316	7	s.h	s.h	PROPN
admet-579	316	8	.	.	PROPN
admet-579	316	9	lockhart	lockhart	PROPN
admet-579	316	10	,	,	PUNCT
admet-579	316	11	e.i	e.i	PROPN
admet-579	316	12	.	.	PROPN
admet-579	316	13	eger	eger	PROPN
admet-579	316	14	,	,	PUNCT
admet-579	316	15	2nd	2nd	PROPN
admet-579	316	16	,	,	PUNCT
admet-579	316	17	r.b	r.b	PROPN
admet-579	316	18	.	.	PROPN
admet-579	316	19	weiskopf	weiskopf	PROPN
admet-579	316	20	,	,	PUNCT
admet-579	316	21	j.	j.	PROPN
admet-579	316	22	liu	liu	PROPN
admet-579	316	23	,	,	PUNCT
admet-579	316	24	m.	m.	NOUN
admet-579	316	25	laster	laster	PROPN
admet-579	316	26	,	,	PUNCT
admet-579	316	27	s.	s.	PROPN
admet-579	316	28	taheri	taheri	PROPN
admet-579	316	29	,	,	PUNCT
admet-579	316	30	n.a	n.a	PROPN
admet-579	316	31	.	.	PROPN
admet-579	316	32	peterson	peterson	PROPN
admet-579	316	33	.	.	PROPN
admet-579	316	34	comparison	comparison	NOUN
admet-579	316	35	of	of	ADP
admet-579	316	36	kinetics	kinetic	NOUN
admet-579	316	37	of	of	ADP
admet-579	316	38	sevoflurane	sevoflurane	NOUN
admet-579	316	39	and	and	CCONJ
admet-579	316	40	isoflurane	isoflurane	NOUN
admet-579	316	41	in	in	ADP
admet-579	316	42	humans	human	NOUN
admet-579	316	43	.	.	PUNCT
admet-579	317	1	anesth	anesth	PROPN
admet-579	317	2	analg	analg	PROPN
admet-579	317	3	72	72	NUM
admet-579	317	4	(	(	PUNCT
admet-579	317	5	1991	1991	NUM
admet-579	317	6	)	)	PUNCT
admet-579	317	7	316	316	NUM
admet-579	317	8	-	-	SYM
admet-579	317	9	324	324	NUM
admet-579	317	10	.	.	PUNCT
admet-579	318	1	[	[	X
admet-579	318	2	16	16	NUM
admet-579	318	3	]	]	X
admet-579	318	4	e.	e.	PROPN
admet-579	318	5	johansson	johansson	PROPN
admet-579	318	6	,	,	PUNCT
admet-579	318	7	a.	a.	PROPN
admet-579	318	8	ohlsson	ohlsson	PROPN
admet-579	318	9	,	,	PUNCT
admet-579	318	10	j.e	j.e	PROPN
admet-579	318	11	.	.	PROPN
admet-579	318	12	lindgren	lindgren	PROPN
admet-579	318	13	,	,	PUNCT
admet-579	318	14	s.	s.	PROPN
admet-579	318	15	agurell	agurell	PROPN
admet-579	318	16	,	,	PUNCT
admet-579	318	17	h.	h.	PROPN
admet-579	318	18	gillespie	gillespie	PROPN
admet-579	318	19	,	,	PUNCT
admet-579	318	20	l.e	l.e	PROPN
admet-579	318	21	.	.	PROPN
admet-579	318	22	hollister	hollister	PROPN
admet-579	318	23	.	.	PUNCT
admet-579	319	1	single	single	ADJ
admet-579	319	2	-	-	PUNCT
admet-579	319	3	dose	dose	ADJ
admet-579	319	4	kinetics	kinetic	NOUN
admet-579	319	5	of	of	ADP
admet-579	319	6	deuterium	deuterium	NOUN
admet-579	319	7	-	-	PUNCT
admet-579	319	8	labelled	label	VERB
admet-579	319	9	cannabinol	cannabinol	NOUN
admet-579	319	10	in	in	ADP
admet-579	319	11	man	man	NOUN
admet-579	319	12	after	after	ADP
admet-579	319	13	intravenous	intravenous	ADJ
admet-579	319	14	administration	administration	NOUN
admet-579	319	15	and	and	CCONJ
admet-579	319	16	smoking	smoking	NOUN
admet-579	319	17	.	.	PROPN
admet-579	319	18	biomed	biome	VERB
admet-579	319	19	environ	environ	X
admet-579	319	20	mass	mass	PROPN
admet-579	319	21	spectrom	spectrom	PROPN
admet-579	319	22	14	14	NUM
admet-579	319	23	(	(	PUNCT
admet-579	319	24	1987	1987	NUM
admet-579	319	25	)	)	PUNCT
admet-579	319	26	495	495	NUM
admet-579	319	27	-	-	SYM
admet-579	319	28	499	499	NUM
admet-579	319	29	.	.	PUNCT
admet-579	320	1	[	[	X
admet-579	320	2	17	17	NUM
admet-579	320	3	]	]	X
admet-579	320	4	d.g	d.g	PROPN
admet-579	320	5	.	.	PROPN
admet-579	320	6	levitt	levitt	PROPN
admet-579	320	7	,	,	PUNCT
admet-579	320	8	t.w	t.w	PROPN
admet-579	320	9	.	.	PROPN
admet-579	320	10	schnider	schnider	NOUN
admet-579	320	11	.	.	PUNCT
admet-579	321	1	human	human	ADJ
admet-579	321	2	physiologically	physiologically	ADV
admet-579	321	3	based	base	VERB
admet-579	321	4	pharmacokinetic	pharmacokinetic	ADJ
admet-579	321	5	model	model	NOUN
admet-579	321	6	for	for	ADP
admet-579	321	7	propofol	propofol	NOUN
admet-579	321	8	.	.	PUNCT
admet-579	322	1	bmc	bmc	ADJ
admet-579	322	2	anesthesiol	anesthesiol	NOUN
admet-579	322	3	5	5	NUM
admet-579	322	4	(	(	PUNCT
admet-579	322	5	2005	2005	NUM
admet-579	322	6	)	)	PUNCT
admet-579	322	7	4	4	NUM
admet-579	322	8	.	.	PUNCT
admet-579	323	1	[	[	X
admet-579	323	2	18	18	NUM
admet-579	323	3	]	]	X
admet-579	323	4	f.	f.	PROPN
admet-579	323	5	servin	servin	PROPN
admet-579	323	6	,	,	PUNCT
admet-579	323	7	r.	r.	PROPN
admet-579	323	8	farinotti	farinotti	PROPN
admet-579	323	9	,	,	PUNCT
admet-579	323	10	j.p	j.p	PROPN
admet-579	323	11	.	.	PROPN
admet-579	323	12	haberer	haberer	PROPN
admet-579	323	13	,	,	PUNCT
admet-579	323	14	j.m	j.m	PROPN
admet-579	323	15	.	.	PROPN
admet-579	323	16	desmonts	desmont	NOUN
admet-579	323	17	.	.	PUNCT
admet-579	324	1	propofol	propofol	NOUN
admet-579	324	2	infusion	infusion	NOUN
admet-579	324	3	for	for	ADP
admet-579	324	4	maintenance	maintenance	NOUN
admet-579	324	5	of	of	ADP
admet-579	324	6	anesthesia	anesthesia	NOUN
admet-579	324	7	in	in	ADP
admet-579	324	8	morbidly	morbidly	ADV
admet-579	324	9	obese	obese	ADJ
admet-579	324	10	patients	patient	NOUN
admet-579	324	11	receiving	receive	VERB
admet-579	324	12	nitrous	nitrous	ADJ
admet-579	324	13	oxide	oxide	NOUN
admet-579	324	14	.	.	PUNCT
admet-579	325	1	a	a	DET
admet-579	325	2	clinical	clinical	ADJ
admet-579	325	3	and	and	CCONJ
admet-579	325	4	pharmacokinetic	pharmacokinetic	ADJ
admet-579	325	5	study	study	NOUN
admet-579	325	6	.	.	PUNCT
admet-579	326	1	anesthesiology	anesthesiology	NOUN
admet-579	326	2	78	78	NUM
admet-579	326	3	(	(	PUNCT
admet-579	326	4	1993	1993	NUM
admet-579	326	5	)	)	PUNCT
admet-579	326	6	657	657	NUM
admet-579	326	7	-	-	SYM
admet-579	326	8	665	665	NUM
admet-579	326	9	.	.	PUNCT
admet-579	327	1	[	[	X
admet-579	327	2	19	19	NUM
admet-579	327	3	]	]	X
admet-579	327	4	d.	d.	PROPN
admet-579	327	5	mackay	mackay	PROPN
admet-579	327	6	,	,	PUNCT
admet-579	327	7	a.	a.	PROPN
admet-579	327	8	fraser	fraser	PROPN
admet-579	327	9	.	.	PUNCT
admet-579	328	1	kenneth	kenneth	PROPN
admet-579	328	2	mellanby	mellanby	PROPN
admet-579	328	3	review	review	PROPN
admet-579	328	4	award	award	NOUN
admet-579	328	5	.	.	PUNCT
admet-579	329	1	bioaccumulation	bioaccumulation	NOUN
admet-579	329	2	of	of	ADP
admet-579	329	3	persistent	persistent	ADJ
admet-579	329	4	organic	organic	ADJ
admet-579	329	5	chemicals	chemical	NOUN
admet-579	329	6	:	:	PUNCT
admet-579	329	7	mechanisms	mechanism	NOUN
admet-579	329	8	and	and	CCONJ
admet-579	329	9	models	model	NOUN
admet-579	329	10	.	.	PUNCT
admet-579	330	1	environ	environ	PROPN
admet-579	330	2	pollut	pollut	VERB
admet-579	330	3	110	110	NUM
admet-579	330	4	(	(	PUNCT
admet-579	330	5	2000	2000	NUM
admet-579	330	6	)	)	PUNCT
admet-579	330	7	375	375	NUM
admet-579	330	8	-	-	SYM
admet-579	330	9	391	391	NUM
admet-579	330	10	.	.	PUNCT
admet-579	331	1	[	[	X
admet-579	331	2	20	20	NUM
admet-579	331	3	]	]	PUNCT
admet-579	331	4	a.	a.	NOUN
admet-579	331	5	arancibia	arancibia	PROPN
admet-579	331	6	,	,	PUNCT
admet-579	331	7	j.	j.	PROPN
admet-579	331	8	guttmann	guttmann	PROPN
admet-579	331	9	,	,	PUNCT
admet-579	331	10	g.	g.	PROPN
admet-579	331	11	gonzalez	gonzalez	PROPN
admet-579	331	12	,	,	PUNCT
admet-579	331	13	c.	c.	PROPN
admet-579	331	14	gonzalez	gonzalez	PROPN
admet-579	331	15	.	.	PUNCT
admet-579	332	1	absorption	absorption	NOUN
admet-579	332	2	and	and	CCONJ
admet-579	332	3	disposition	disposition	NOUN
admet-579	332	4	kinetics	kinetic	NOUN
admet-579	332	5	of	of	ADP
admet-579	332	6	amoxicillin	amoxicillin	PROPN
admet-579	332	7	in	in	ADP
admet-579	332	8	normal	normal	ADJ
admet-579	332	9	human	human	ADJ
admet-579	332	10	subjects	subject	NOUN
admet-579	332	11	.	.	PUNCT
admet-579	333	1	antimicrob	antimicrob	PROPN
admet-579	333	2	agents	agent	NOUN
admet-579	333	3	chemother	chemother	PROPN
admet-579	333	4	17	17	NUM
admet-579	333	5	(	(	PUNCT
admet-579	333	6	1980	1980	NUM
admet-579	333	7	)	)	PUNCT
admet-579	333	8	199	199	NUM
admet-579	333	9	-	-	SYM
admet-579	333	10	202	202	NUM
admet-579	333	11	.	.	PUNCT
admet-579	334	1	[	[	X
admet-579	334	2	21	21	NUM
admet-579	334	3	]	]	X
admet-579	334	4	c.	c.	NOUN
admet-579	334	5	crone	crone	NOUN
admet-579	334	6	,	,	PUNCT
admet-579	334	7	d.g	d.g	PROPN
admet-579	334	8	.	.	PROPN
admet-579	334	9	levitt	levitt	PROPN
admet-579	334	10	.	.	PUNCT
admet-579	335	1	capillary	capillary	ADJ
admet-579	335	2	permeability	permeability	NOUN
admet-579	335	3	to	to	ADP
admet-579	335	4	small	small	ADJ
admet-579	335	5	solutes	solute	NOUN
admet-579	335	6	.	.	PUNCT
admet-579	336	1	in	in	ADP
admet-579	336	2	:	:	PUNCT
admet-579	336	3	e.m	e.m	PROPN
admet-579	336	4	.	.	PROPN
admet-579	336	5	renkin	renkin	PROPN
admet-579	336	6	,	,	PUNCT
admet-579	336	7	c.c	c.c	PROPN
admet-579	336	8	.	.	PROPN
admet-579	336	9	michell	michell	PROPN
admet-579	336	10	(	(	PUNCT
admet-579	336	11	eds	eds	PROPN
admet-579	336	12	.	.	PUNCT
admet-579	336	13	)	)	PUNCT
admet-579	337	1	the	the	DET
admet-579	337	2	microcirculation	microcirculation	NOUN
admet-579	337	3	,	,	PUNCT
admet-579	337	4	handbook	handbook	NOUN
admet-579	337	5	of	of	ADP
admet-579	337	6	physiology	physiology	NOUN
admet-579	337	7	,	,	PUNCT
admet-579	337	8	american	american	ADJ
admet-579	337	9	physiological	physiological	ADJ
admet-579	337	10	society	society	NOUN
admet-579	337	11	,	,	PUNCT
admet-579	337	12	bethesda	bethesda	PROPN
admet-579	337	13	,	,	PUNCT
admet-579	337	14	md	md	PROPN
admet-579	337	15	.	.	PROPN
admet-579	337	16	,	,	PUNCT
admet-579	337	17	1984	1984	NUM
admet-579	337	18	,	,	PUNCT
admet-579	337	19	pp	pp	ADV
admet-579	337	20	.	.	PUNCT
admet-579	338	1	411	411	NUM
admet-579	338	2	-	-	SYM
admet-579	338	3	466	466	NUM
admet-579	338	4	.	.	PUNCT
admet-579	339	1	[	[	X
admet-579	339	2	22	22	NUM
admet-579	339	3	]	]	X
admet-579	339	4	y.k	y.k	PROPN
admet-579	339	5	.	.	PROPN
admet-579	339	6	odeh	odeh	PROPN
admet-579	339	7	,	,	PUNCT
admet-579	339	8	z.	z.	PROPN
admet-579	339	9	wang	wang	PROPN
admet-579	339	10	,	,	PUNCT
admet-579	339	11	t.i	t.i	PROPN
admet-579	339	12	.	.	PROPN
admet-579	339	13	ruo	ruo	PROPN
admet-579	339	14	,	,	PUNCT
admet-579	339	15	t.	t.	PROPN
admet-579	339	16	wang	wang	PROPN
admet-579	339	17	,	,	PUNCT
admet-579	339	18	m.c	m.c	PROPN
admet-579	339	19	.	.	PROPN
admet-579	339	20	frederiksen	frederiksen	PROPN
admet-579	339	21	,	,	PUNCT
admet-579	339	22	p.a	p.a	PROPN
admet-579	339	23	.	.	PROPN
admet-579	339	24	pospisil	pospisil	PROPN
admet-579	339	25	,	,	PUNCT
admet-579	339	26	a.j	a.j	PROPN
admet-579	339	27	.	.	PROPN
admet-579	339	28	atkinson	atkinson	PROPN
admet-579	339	29	,	,	PUNCT
admet-579	339	30	jr	jr	PROPN
admet-579	339	31	.	.	PUNCT
admet-579	339	32	simultaneous	simultaneous	ADJ
admet-579	339	33	analysis	analysis	NOUN
admet-579	339	34	of	of	ADP
admet-579	339	35	inulin	inulin	NOUN
admet-579	339	36	and	and	CCONJ
admet-579	339	37	15n2	15n2	NUM
admet-579	339	38	-	-	PUNCT
admet-579	339	39	urea	urea	NOUN
admet-579	339	40	kinetics	kinetic	NOUN
admet-579	339	41	in	in	ADP
admet-579	339	42	humans	human	NOUN
admet-579	339	43	.	.	PUNCT
admet-579	340	1	clin	clin	PROPN
admet-579	340	2	pharmacol	pharmacol	PROPN
admet-579	340	3	ther	ther	PROPN
admet-579	340	4	53	53	NUM
admet-579	340	5	(	(	PUNCT
admet-579	340	6	1993	1993	NUM
admet-579	340	7	)	)	PUNCT
admet-579	340	8	419	419	NUM
admet-579	340	9	-	-	SYM
admet-579	340	10	425	425	NUM
admet-579	340	11	.	.	PUNCT
admet-579	341	1	[	[	X
admet-579	341	2	23	23	NUM
admet-579	341	3	]	]	X
admet-579	341	4	y.m	y.m	PROPN
admet-579	341	5	.	.	PROPN
admet-579	341	6	tan	tan	PROPN
admet-579	341	7	,	,	PUNCT
admet-579	341	8	r.r	r.r	PROPN
admet-579	341	9	.	.	PROPN
admet-579	341	10	worley	worley	PROPN
admet-579	341	11	,	,	PUNCT
admet-579	341	12	j.a	j.a	PROPN
admet-579	341	13	.	.	PROPN
admet-579	341	14	leonard	leonard	PROPN
admet-579	341	15	,	,	PUNCT
admet-579	341	16	j.w	j.w	PROPN
admet-579	341	17	.	.	PROPN
admet-579	341	18	fisher	fisher	PROPN
admet-579	341	19	.	.	PUNCT
admet-579	342	1	challenges	challenge	NOUN
admet-579	342	2	associated	associate	VERB
admet-579	342	3	with	with	ADP
admet-579	342	4	applying	apply	VERB
admet-579	342	5	physiologically	physiologically	ADV
admet-579	342	6	based	base	VERB
admet-579	342	7	pharmacokinetic	pharmacokinetic	ADJ
admet-579	342	8	modeling	modeling	NOUN
admet-579	342	9	for	for	ADP
admet-579	342	10	public	public	ADJ
admet-579	342	11	health	health	NOUN
admet-579	342	12	decision	decision	NOUN
admet-579	342	13	-	-	PUNCT
admet-579	342	14	making	making	NOUN
admet-579	342	15	.	.	PUNCT
admet-579	343	1	toxicol	toxicol	PROPN
admet-579	343	2	sci	sci	PROPN
admet-579	343	3	162	162	NUM
admet-579	343	4	(	(	PUNCT
admet-579	343	5	2018	2018	NUM
admet-579	343	6	)	)	PUNCT
admet-579	343	7	341	341	NUM
admet-579	343	8	-	-	SYM
admet-579	343	9	348	348	NUM
admet-579	343	10	.	.	PUNCT
admet-579	344	1	©	©	PROPN
admet-579	344	2	2018	2018	NUM
admet-579	344	3	by	by	ADP
admet-579	344	4	the	the	DET
admet-579	344	5	authors	author	NOUN
admet-579	344	6	;	;	PUNCT
admet-579	345	1	licensee	licensee	PROPN
admet-579	345	2	iapc	iapc	PROPN
admet-579	345	3	,	,	PUNCT
admet-579	345	4	zagreb	zagreb	PROPN
admet-579	345	5	,	,	PUNCT
admet-579	345	6	croatia	croatia	PROPN
admet-579	345	7	.	.	PUNCT
admet-579	346	1	this	this	DET
admet-579	346	2	article	article	NOUN
admet-579	346	3	is	be	AUX
admet-579	346	4	an	an	DET
admet-579	346	5	open	open	ADJ
admet-579	346	6	-	-	PUNCT
admet-579	346	7	access	access	NOUN
admet-579	346	8	article	article	NOUN
admet-579	346	9	distributed	distribute	VERB
admet-579	346	10	under	under	ADP
admet-579	346	11	the	the	DET
admet-579	346	12	terms	term	NOUN
admet-579	346	13	and	and	CCONJ
admet-579	346	14	conditions	condition	NOUN
admet-579	346	15	of	of	ADP
admet-579	346	16	the	the	DET
admet-579	346	17	creative	creative	ADJ
admet-579	346	18	commons	common	NOUN
admet-579	346	19	attribution	attribution	NOUN
admet-579	346	20	license	license	NOUN
admet-579	346	21	(	(	PUNCT
admet-579	346	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-579	346	23	)	)	PUNCT
admet-579	346	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN