id	sid	tid	token	lemma	pos
admet-613	1	1	animal	animal	NOUN
admet-613	1	2	model	model	NOUN
admet-613	1	3	investigation	investigation	NOUN
admet-613	1	4	suggests	suggest	VERB
admet-613	1	5	betamethasone	betamethasone	NOUN
admet-613	1	6	alters	alter	VERB
admet-613	1	7	the	the	DET
admet-613	1	8	pharmacokinetics	pharmacokinetic	NOUN
admet-613	1	9	of	of	ADP
admet-613	1	10	amikacin	amikacin	PROPN
admet-613	1	11	doi	doi	NOUN
admet-613	1	12	:	:	PUNCT
admet-613	1	13	10.5599	10.5599	NUM
admet-613	1	14	/	/	SYM
admet-613	1	15	admet.613	admet.613	PROPN
admet-613	1	16	279	279	NUM
admet-613	1	17	admet	admet	X
admet-613	1	18	&	&	CCONJ
admet-613	1	19	dmpk	dmpk	PROPN
admet-613	1	20	6(4	6(4	PROPN
admet-613	1	21	)	)	PUNCT
admet-613	1	22	(	(	PUNCT
admet-613	1	23	2018	2018	NUM
admet-613	1	24	)	)	PUNCT
admet-613	1	25	279	279	NUM
admet-613	1	26	-	-	SYM
admet-613	1	27	283	283	NUM
admet-613	1	28	;	;	PUNCT
admet-613	1	29	doi	doi	NOUN
admet-613	1	30	:	:	PUNCT
admet-613	1	31	http://dx.doi.org/10.5599/admet.613	http://dx.doi.org/10.5599/admet.613	ADJ
admet-613	1	32	open	open	ADJ
admet-613	1	33	access	access	NOUN
admet-613	1	34	:	:	PUNCT
admet-613	1	35	issn	issn	PROPN
admet-613	1	36	:	:	PUNCT
admet-613	1	37	1848	1848	NUM
admet-613	1	38	-	-	SYM
admet-613	1	39	7718	7718	NUM
admet-613	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-613	1	41	short	short	ADJ
admet-613	1	42	communication	communication	NOUN
admet-613	1	43	animal	animal	NOUN
admet-613	1	44	model	model	NOUN
admet-613	1	45	investigation	investigation	NOUN
admet-613	1	46	suggests	suggest	VERB
admet-613	1	47	betamethasone	betamethasone	NOUN
admet-613	1	48	alters	alter	VERB
admet-613	1	49	the	the	DET
admet-613	1	50	pharmacokinetics	pharmacokinetic	NOUN
admet-613	1	51	of	of	ADP
admet-613	1	52	amikacin	amikacin	PROPN
admet-613	1	53	seth	seth	PROPN
admet-613	1	54	kwabena	kwabena	PROPN
admet-613	1	55	amponsah1	amponsah1	PROPN
admet-613	1	56	,	,	PUNCT
admet-613	1	57	kwabena	kwabena	PROPN
admet-613	1	58	frimpong	frimpong	PROPN
admet-613	1	59	-	-	PUNCT
admet-613	1	60	manso	manso	NOUN
admet-613	1	61	opuni2	opuni2	PROPN
admet-613	1	62	*	*	PUNCT
admet-613	1	63	,	,	PUNCT
admet-613	1	64	ama	ama	PROPN
admet-613	1	65	asiedua	asiedua	NOUN
admet-613	1	66	donkor1	donkor1	NOUN
admet-613	1	67	1	1	NUM
admet-613	1	68	department	department	NOUN
admet-613	1	69	of	of	ADP
admet-613	1	70	pharmacology	pharmacology	NOUN
admet-613	1	71	and	and	CCONJ
admet-613	1	72	toxicology	toxicology	NOUN
admet-613	1	73	,	,	PUNCT
admet-613	1	74	school	school	NOUN
admet-613	1	75	of	of	ADP
admet-613	1	76	pharmacy	pharmacy	NOUN
admet-613	1	77	,	,	PUNCT
admet-613	1	78	university	university	PROPN
admet-613	1	79	of	of	ADP
admet-613	1	80	ghana	ghana	PROPN
admet-613	1	81	,	,	PUNCT
admet-613	1	82	accra	accra	PROPN
admet-613	1	83	,	,	PUNCT
admet-613	1	84	ghana	ghana	PROPN
admet-613	1	85	2	2	NUM
admet-613	1	86	department	department	NOUN
admet-613	1	87	of	of	ADP
admet-613	1	88	pharmaceutical	pharmaceutical	ADJ
admet-613	1	89	chemistry	chemistry	NOUN
admet-613	1	90	,	,	PUNCT
admet-613	1	91	school	school	NOUN
admet-613	1	92	of	of	ADP
admet-613	1	93	pharmacy	pharmacy	NOUN
admet-613	1	94	,	,	PUNCT
admet-613	1	95	university	university	PROPN
admet-613	1	96	of	of	ADP
admet-613	1	97	ghana	ghana	PROPN
admet-613	1	98	,	,	PUNCT
admet-613	1	99	accra	accra	PROPN
admet-613	1	100	,	,	PUNCT
admet-613	1	101	ghana	ghana	PROPN
admet-613	1	102	*	*	PUNCT
admet-613	1	103	corresponding	correspond	VERB
admet-613	1	104	author	author	NOUN
admet-613	1	105	:	:	PUNCT
admet-613	1	106	e	e	NOUN
admet-613	1	107	-	-	NOUN
admet-613	1	108	mail	mail	NOUN
admet-613	1	109	:	:	PUNCT
admet-613	1	110	kfopuni@ug.edu.gh	kfopuni@ug.edu.gh	NOUN
admet-613	1	111	;	;	PUNCT
admet-613	1	112	telephone	telephone	NOUN
admet-613	1	113	:	:	PUNCT
admet-613	1	114	+233208260595	+233208260595	PROPN
admet-613	1	115	received	receive	VERB
admet-613	1	116	:	:	PUNCT
admet-613	1	117	august	august	PROPN
admet-613	1	118	30	30	NUM
admet-613	1	119	,	,	PUNCT
admet-613	1	120	2018	2018	NUM
admet-613	1	121	;	;	PUNCT
admet-613	1	122	revised	revise	VERB
admet-613	1	123	:	:	PUNCT
admet-613	1	124	october	october	PROPN
admet-613	1	125	25	25	NUM
admet-613	1	126	,	,	PUNCT
admet-613	1	127	2018	2018	NUM
admet-613	1	128	;	;	PUNCT
admet-613	1	129	published	publish	VERB
admet-613	1	130	:	:	PUNCT
admet-613	1	131	november	november	PROPN
admet-613	1	132	01	01	NUM
admet-613	1	133	,	,	PUNCT
admet-613	1	134	2018	2018	NUM
admet-613	1	135	abstract	abstract	ADJ
admet-613	1	136	corticosteroids	corticosteroid	NOUN
admet-613	1	137	,	,	PUNCT
admet-613	1	138	such	such	ADJ
admet-613	1	139	as	as	ADP
admet-613	1	140	betamethasone	betamethasone	NOUN
admet-613	1	141	,	,	PUNCT
admet-613	1	142	are	be	AUX
admet-613	1	143	sometimes	sometimes	ADV
admet-613	1	144	administered	administer	VERB
admet-613	1	145	to	to	ADP
admet-613	1	146	women	woman	NOUN
admet-613	1	147	who	who	PRON
admet-613	1	148	are	be	AUX
admet-613	1	149	at	at	ADP
admet-613	1	150	risk	risk	NOUN
admet-613	1	151	of	of	ADP
admet-613	1	152	pre	pre	ADJ
admet-613	1	153	-	-	ADJ
admet-613	1	154	term	term	ADJ
admet-613	1	155	delivery	delivery	NOUN
admet-613	1	156	.	.	PUNCT
admet-613	2	1	these	these	DET
admet-613	2	2	corticosteroids	corticosteroid	NOUN
admet-613	2	3	cross	cross	VERB
admet-613	2	4	the	the	DET
admet-613	2	5	placenta	placenta	NOUN
admet-613	2	6	to	to	ADP
admet-613	2	7	the	the	DET
admet-613	2	8	fetus	fetus	NOUN
admet-613	2	9	and	and	CCONJ
admet-613	2	10	decrease	decrease	VERB
admet-613	2	11	respiratory	respiratory	ADJ
admet-613	2	12	distress	distress	NOUN
admet-613	2	13	syndrome	syndrome	NOUN
admet-613	2	14	in	in	ADP
admet-613	2	15	preterm	preterm	ADJ
admet-613	2	16	newborns	newborn	NOUN
admet-613	2	17	.	.	PUNCT
admet-613	3	1	preterm	preterm	ADJ
admet-613	3	2	newborns	newborn	NOUN
admet-613	3	3	are	be	AUX
admet-613	3	4	often	often	ADV
admet-613	3	5	susceptible	susceptible	ADJ
admet-613	3	6	to	to	ADP
admet-613	3	7	infections	infection	NOUN
admet-613	3	8	partly	partly	ADV
admet-613	3	9	due	due	ADP
admet-613	3	10	to	to	ADP
admet-613	3	11	their	their	PRON
admet-613	3	12	immature	immature	ADJ
admet-613	3	13	immune	immune	ADJ
admet-613	3	14	system	system	NOUN
admet-613	3	15	.	.	PUNCT
admet-613	4	1	amikacin	amikacin	PROPN
admet-613	4	2	is	be	AUX
admet-613	4	3	one	one	NUM
admet-613	4	4	of	of	ADP
admet-613	4	5	the	the	DET
admet-613	4	6	aminoglycosides	aminoglycoside	NOUN
admet-613	4	7	used	use	VERB
admet-613	4	8	in	in	ADP
admet-613	4	9	the	the	DET
admet-613	4	10	treatment	treatment	NOUN
admet-613	4	11	of	of	ADP
admet-613	4	12	newborn	newborn	ADJ
admet-613	4	13	infections	infection	NOUN
admet-613	4	14	.	.	PUNCT
admet-613	5	1	there	there	PRON
admet-613	5	2	is	be	VERB
admet-613	5	3	,	,	PUNCT
admet-613	5	4	however	however	ADV
admet-613	5	5	,	,	PUNCT
admet-613	5	6	a	a	DET
admet-613	5	7	dearth	dearth	NOUN
admet-613	5	8	of	of	ADP
admet-613	5	9	information	information	NOUN
admet-613	5	10	on	on	ADP
admet-613	5	11	the	the	DET
admet-613	5	12	effect	effect	NOUN
admet-613	5	13	of	of	ADP
admet-613	5	14	prenatal	prenatal	ADJ
admet-613	5	15	corticosteroids	corticosteroid	NOUN
admet-613	5	16	on	on	ADP
admet-613	5	17	the	the	DET
admet-613	5	18	disposition	disposition	NOUN
admet-613	5	19	of	of	ADP
admet-613	5	20	aminoglycosides	aminoglycoside	NOUN
admet-613	5	21	administered	administer	VERB
admet-613	5	22	to	to	ADP
admet-613	5	23	newborns	newborn	NOUN
admet-613	5	24	days	day	NOUN
admet-613	5	25	later	later	ADV
admet-613	5	26	.	.	PUNCT
admet-613	6	1	we	we	PRON
admet-613	6	2	evaluated	evaluate	VERB
admet-613	6	3	the	the	DET
admet-613	6	4	effect	effect	NOUN
admet-613	6	5	of	of	ADP
admet-613	6	6	pre	pre	NOUN
admet-613	6	7	-	-	NOUN
admet-613	6	8	administration	administration	NOUN
admet-613	6	9	of	of	ADP
admet-613	6	10	betamethasone	betamethasone	PROPN
admet-613	6	11	on	on	ADP
admet-613	6	12	the	the	DET
admet-613	6	13	disposition	disposition	NOUN
admet-613	6	14	of	of	ADP
admet-613	6	15	amikacin	amikacin	PROPN
admet-613	6	16	,	,	PUNCT
admet-613	6	17	72	72	NUM
admet-613	6	18	h	h	NOUN
admet-613	6	19	after	after	ADP
admet-613	6	20	last	last	ADJ
admet-613	6	21	dose	dose	NOUN
admet-613	6	22	of	of	ADP
admet-613	6	23	betamethasone	betamethasone	PROPN
admet-613	6	24	,	,	PUNCT
admet-613	6	25	using	use	VERB
admet-613	6	26	an	an	DET
admet-613	6	27	animal	animal	NOUN
admet-613	6	28	model	model	NOUN
admet-613	6	29	.	.	PUNCT
admet-613	7	1	the	the	DET
admet-613	7	2	pharmacokinetic	pharmacokinetic	ADJ
admet-613	7	3	parameters	parameter	NOUN
admet-613	7	4	of	of	ADP
admet-613	7	5	rats	rat	NOUN
admet-613	7	6	administered	administer	VERB
admet-613	7	7	betamethasone	betamethasone	PROPN
admet-613	7	8	followed	follow	VERB
admet-613	7	9	by	by	ADP
admet-613	7	10	amikacin	amikacin	PROPN
admet-613	7	11	vis	vis	X
admet-613	7	12	-	-	PUNCT
admet-613	7	13	avis	avis	ADJ
admet-613	7	14	rats	rat	NOUN
admet-613	7	15	administered	administer	VERB
admet-613	7	16	saline	saline	NOUN
admet-613	7	17	followed	follow	VERB
admet-613	7	18	by	by	ADP
admet-613	7	19	amikacin	amikacin	PROPN
admet-613	7	20	were	be	AUX
admet-613	7	21	as	as	SCONJ
admet-613	7	22	follows	follow	VERB
admet-613	7	23	:	:	PUNCT
admet-613	7	24	cmax	cmax	NOUN
admet-613	7	25	;	;	PUNCT
admet-613	7	26	16.6	16.6	NUM
admet-613	7	27	μmol	μmol	NOUN
admet-613	7	28	l	l	NOUN
admet-613	7	29	-1	-1	NOUN
admet-613	7	30	vs.	vs.	ADP
admet-613	7	31	31.4	31.4	NUM
admet-613	7	32	μmol	μmol	NOUN
admet-613	7	33	l	l	NOUN
admet-613	7	34	-1	-1	NOUN
admet-613	7	35	,	,	PUNCT
admet-613	7	36	auc0→8	auc0→8	PROPN
admet-613	7	37	;	;	PUNCT
admet-613	7	38	26.8	26.8	NUM
admet-613	7	39	μmol	μmol	NOUN
admet-613	7	40	h	h	NOUN
admet-613	7	41	l	l	NOUN
admet-613	7	42	-1	-1	X
admet-613	7	43	vs.	vs.	ADP
admet-613	7	44	153.5	153.5	NUM
admet-613	7	45	μmol	μmol	NOUN
admet-613	7	46	h	h	NOUN
admet-613	7	47	l	l	NOUN
admet-613	7	48	-1	-1	NOUN
admet-613	7	49	,	,	PUNCT
admet-613	7	50	ke	ke	NOUN
admet-613	7	51	;	;	PUNCT
admet-613	7	52	0.26	0.26	NUM
admet-613	7	53	h	h	NOUN
admet-613	7	54	-1	-1	X
admet-613	7	55	vs.	vs.	X
admet-613	7	56	0.18	0.18	NUM
admet-613	7	57	h	h	NOUN
admet-613	7	58	-1	-1	PUNCT
admet-613	7	59	,	,	PUNCT
admet-613	7	60	and	and	CCONJ
admet-613	7	61	t1/2	t1/2	VERB
admet-613	7	62	;	;	PUNCT
admet-613	7	63	2.6	2.6	NUM
admet-613	7	64	h	h	NOUN
admet-613	7	65	vs.	vs.	ADP
admet-613	7	66	3.9	3.9	NUM
admet-613	7	67	h	h	NOUN
admet-613	7	68	,	,	PUNCT
admet-613	7	69	respectively	respectively	ADV
admet-613	7	70	.	.	PUNCT
admet-613	8	1	about	about	ADP
admet-613	8	2	a	a	DET
admet-613	8	3	1.5	1.5	NUM
admet-613	8	4	-	-	ADJ
admet-613	8	5	fold	fold	ADJ
admet-613	8	6	increase	increase	NOUN
admet-613	8	7	in	in	ADP
admet-613	8	8	the	the	DET
admet-613	8	9	elimination	elimination	NOUN
admet-613	8	10	of	of	ADP
admet-613	8	11	amikacin	amikacin	PROPN
admet-613	8	12	was	be	AUX
admet-613	8	13	observed	observe	VERB
admet-613	8	14	in	in	ADP
admet-613	8	15	the	the	DET
admet-613	8	16	sprague	sprague	NOUN
admet-613	8	17	-	-	PUNCT
admet-613	8	18	dawley	dawley	NOUN
admet-613	8	19	rats	rat	NOUN
admet-613	8	20	pretreated	pretreate	VERB
admet-613	8	21	with	with	ADP
admet-613	8	22	betamethasone	betamethasone	NOUN
admet-613	8	23	compared	compare	VERB
admet-613	8	24	with	with	ADP
admet-613	8	25	those	those	PRON
admet-613	8	26	pre	pre	VERB
admet-613	8	27	-	-	VERB
admet-613	8	28	treated	treat	VERB
admet-613	8	29	with	with	ADP
admet-613	8	30	saline	saline	NOUN
admet-613	8	31	.	.	PUNCT
admet-613	9	1	this	this	PRON
admet-613	9	2	ultimately	ultimately	ADV
admet-613	9	3	led	lead	VERB
admet-613	9	4	to	to	ADP
admet-613	9	5	differences	difference	NOUN
admet-613	9	6	in	in	ADP
admet-613	9	7	the	the	DET
admet-613	9	8	other	other	ADJ
admet-613	9	9	pharmacokinetic	pharmacokinetic	ADJ
admet-613	9	10	parameters	parameter	NOUN
admet-613	9	11	amongst	amongst	ADP
admet-613	9	12	the	the	DET
admet-613	9	13	two	two	NUM
admet-613	9	14	groups	group	NOUN
admet-613	9	15	of	of	ADP
admet-613	9	16	rats	rat	NOUN
admet-613	9	17	.	.	PUNCT
admet-613	10	1	although	although	SCONJ
admet-613	10	2	an	an	DET
admet-613	10	3	animal	animal	NOUN
admet-613	10	4	model	model	NOUN
admet-613	10	5	investigation	investigation	NOUN
admet-613	10	6	showed	show	VERB
admet-613	10	7	some	some	DET
admet-613	10	8	level	level	NOUN
admet-613	10	9	of	of	ADP
admet-613	10	10	interaction	interaction	NOUN
admet-613	10	11	,	,	PUNCT
admet-613	10	12	a	a	DET
admet-613	10	13	follow	follow	VERB
admet-613	10	14	-	-	PUNCT
admet-613	10	15	up	up	ADP
admet-613	10	16	study	study	NOUN
admet-613	10	17	in	in	ADP
admet-613	10	18	preterm	preterm	ADJ
admet-613	10	19	newborns	newborn	NOUN
admet-613	10	20	where	where	SCONJ
admet-613	10	21	possible	possible	ADJ
admet-613	10	22	interaction	interaction	NOUN
admet-613	10	23	of	of	ADP
admet-613	10	24	the	the	DET
admet-613	10	25	two	two	NUM
admet-613	10	26	drugs	drug	NOUN
admet-613	10	27	is	be	AUX
admet-613	10	28	studied	study	VERB
admet-613	10	29	later	later	ADV
admet-613	10	30	than	than	ADP
admet-613	10	31	day	day	NOUN
admet-613	10	32	1	1	NUM
admet-613	10	33	,	,	PUNCT
admet-613	10	34	is	be	AUX
admet-613	10	35	recommended	recommend	VERB
admet-613	10	36	.	.	PUNCT
admet-613	11	1	keywords	keyword	NOUN
admet-613	11	2	excretion	excretion	NOUN
admet-613	11	3	;	;	PUNCT
admet-613	11	4	interaction	interaction	NOUN
admet-613	11	5	;	;	PUNCT
admet-613	11	6	preterm	preterm	ADJ
admet-613	11	7	introduction	introduction	NOUN
admet-613	11	8	according	accord	VERB
admet-613	11	9	to	to	ADP
admet-613	11	10	the	the	DET
admet-613	11	11	world	world	PROPN
admet-613	11	12	health	health	NOUN
admet-613	11	13	organization	organization	NOUN
admet-613	11	14	,	,	PUNCT
admet-613	11	15	about	about	ADV
admet-613	11	16	15	15	NUM
admet-613	11	17	million	million	NUM
admet-613	11	18	babies	baby	NOUN
admet-613	11	19	(	(	PUNCT
admet-613	11	20	more	more	ADJ
admet-613	11	21	than	than	ADP
admet-613	11	22	1	1	NUM
admet-613	11	23	in	in	ADP
admet-613	11	24	10	10	NUM
admet-613	11	25	babies	baby	NOUN
admet-613	11	26	worldwide	worldwide	ADV
admet-613	11	27	)	)	PUNCT
admet-613	11	28	are	be	AUX
admet-613	11	29	born	bear	VERB
admet-613	11	30	prematurely	prematurely	ADV
admet-613	11	31	annually	annually	ADV
admet-613	11	32	[	[	X
admet-613	11	33	1	1	NUM
admet-613	11	34	]	]	PUNCT
admet-613	11	35	.	.	PUNCT
admet-613	12	1	in	in	ADP
admet-613	12	2	2015	2015	NUM
admet-613	12	3	,	,	PUNCT
admet-613	12	4	an	an	DET
admet-613	12	5	estimated	estimate	VERB
admet-613	12	6	1	1	NUM
admet-613	12	7	million	million	NUM
admet-613	12	8	preterm	preterm	NOUN
admet-613	12	9	deaths	death	NOUN
admet-613	12	10	were	be	AUX
admet-613	12	11	recorded	record	VERB
admet-613	12	12	,	,	PUNCT
admet-613	12	13	while	while	SCONJ
admet-613	12	14	many	many	ADJ
admet-613	12	15	survivors	survivor	NOUN
admet-613	12	16	of	of	ADP
admet-613	12	17	preterm	preterm	ADJ
admet-613	12	18	birth	birth	NOUN
admet-613	12	19	faced	face	VERB
admet-613	12	20	life	life	NOUN
admet-613	12	21	-	-	PUNCT
admet-613	12	22	long	long	ADJ
admet-613	12	23	morbidities	morbidity	NOUN
admet-613	12	24	such	such	ADJ
admet-613	12	25	as	as	ADP
admet-613	12	26	learning	learn	VERB
admet-613	12	27	disabilities	disability	NOUN
admet-613	12	28	and	and	CCONJ
admet-613	12	29	respiratory	respiratory	ADJ
admet-613	12	30	problems	problem	NOUN
admet-613	12	31	[	[	X
admet-613	12	32	1	1	NUM
admet-613	12	33	]	]	PUNCT
admet-613	12	34	.	.	PUNCT
admet-613	13	1	newborn	newborn	ADJ
admet-613	13	2	care	care	NOUN
admet-613	13	3	,	,	PUNCT
admet-613	13	4	which	which	PRON
admet-613	13	5	includes	include	VERB
admet-613	13	6	pharmacotherapy	pharmacotherapy	NOUN
admet-613	13	7	,	,	PUNCT
admet-613	13	8	has	have	AUX
admet-613	13	9	been	be	AUX
admet-613	13	10	one	one	NUM
admet-613	13	11	of	of	ADP
admet-613	13	12	the	the	DET
admet-613	13	13	interventions	intervention	NOUN
admet-613	13	14	to	to	PART
admet-613	13	15	reduce	reduce	VERB
admet-613	13	16	the	the	DET
admet-613	13	17	burden	burden	NOUN
admet-613	13	18	of	of	ADP
admet-613	13	19	morbidity	morbidity	NOUN
admet-613	13	20	and	and	CCONJ
admet-613	13	21	mortality	mortality	NOUN
admet-613	13	22	in	in	ADP
admet-613	13	23	this	this	DET
admet-613	13	24	cohort	cohort	NOUN
admet-613	13	25	of	of	ADP
admet-613	13	26	infants	infant	NOUN
admet-613	13	27	.	.	PUNCT
admet-613	14	1	corticosteroids	corticosteroid	NOUN
admet-613	14	2	are	be	AUX
admet-613	14	3	usually	usually	ADV
admet-613	14	4	administered	administer	VERB
admet-613	14	5	to	to	ADP
admet-613	14	6	women	woman	NOUN
admet-613	14	7	who	who	PRON
admet-613	14	8	are	be	AUX
admet-613	14	9	at	at	ADP
admet-613	14	10	risk	risk	NOUN
admet-613	14	11	of	of	ADP
admet-613	14	12	imminent	imminent	ADJ
admet-613	14	13	preterm	preterm	ADJ
admet-613	14	14	birth	birth	NOUN
admet-613	14	15	.	.	PUNCT
admet-613	15	1	betamethasone	betamethasone	NOUN
admet-613	15	2	,	,	PUNCT
admet-613	15	3	a	a	DET
admet-613	15	4	corticosteroid	corticosteroid	NOUN
admet-613	15	5	of	of	ADP
admet-613	15	6	choice	choice	NOUN
admet-613	15	7	in	in	ADP
admet-613	15	8	some	some	DET
admet-613	15	9	resource	resource	NOUN
admet-613	15	10	-	-	PUNCT
admet-613	15	11	poor	poor	ADJ
admet-613	15	12	settings	setting	NOUN
admet-613	15	13	,	,	PUNCT
admet-613	15	14	is	be	AUX
admet-613	15	15	known	know	VERB
admet-613	15	16	to	to	PART
admet-613	15	17	decrease	decrease	VERB
admet-613	15	18	the	the	DET
admet-613	15	19	occurrence	occurrence	NOUN
admet-613	15	20	of	of	ADP
admet-613	15	21	respiratory	respiratory	ADJ
admet-613	15	22	distress	distress	NOUN
admet-613	15	23	syndrome	syndrome	NOUN
admet-613	15	24	in	in	ADP
admet-613	15	25	preterm	preterm	ADJ
admet-613	15	26	newborns	newborn	NOUN
admet-613	15	27	.	.	PUNCT
admet-613	16	1	the	the	DET
admet-613	16	2	main	main	ADJ
admet-613	16	3	mechanism	mechanism	NOUN
admet-613	16	4	of	of	ADP
admet-613	16	5	betamethasone	betamethasone	NOUN
admet-613	16	6	is	be	AUX
admet-613	16	7	to	to	PART
admet-613	16	8	accelerate	accelerate	VERB
admet-613	16	9	the	the	DET
admet-613	16	10	development	development	NOUN
admet-613	16	11	of	of	ADP
admet-613	16	12	types	type	NOUN
admet-613	16	13	i	i	PRON
admet-613	16	14	and	and	CCONJ
admet-613	16	15	ii	ii	PROPN
admet-613	16	16	pneumocytes	pneumocyte	NOUN
admet-613	16	17	(	(	PUNCT
admet-613	16	18	alveolar	alveolar	ADJ
admet-613	16	19	cells	cell	NOUN
admet-613	16	20	)	)	PUNCT
admet-613	16	21	of	of	ADP
admet-613	16	22	the	the	DET
admet-613	16	23	fetus	fetus	NOUN
admet-613	16	24	after	after	SCONJ
admet-613	16	25	the	the	DET
admet-613	16	26	drug	drug	PROPN
admet-613	16	27	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-613	16	28	mailto:kfopuni@ug.edu.gh	mailto:kfopuni@ug.edu.gh	PROPN
admet-613	16	29	amponsah	amponsah	PROPN
admet-613	16	30	et	et	PROPN
admet-613	16	31	al	al	PROPN
admet-613	16	32	.	.	PROPN
admet-613	16	33	admet	admet	PROPN
admet-613	16	34	&	&	CCONJ
admet-613	16	35	dmpk	dmpk	PROPN
admet-613	16	36	6(4	6(4	PROPN
admet-613	16	37	)	)	PUNCT
admet-613	16	38	(	(	PUNCT
admet-613	16	39	2018	2018	NUM
admet-613	16	40	)	)	PUNCT
admet-613	16	41	279	279	NUM
admet-613	16	42	-	-	SYM
admet-613	16	43	283	283	NUM
admet-613	16	44	280	280	NUM
admet-613	16	45	has	have	AUX
admet-613	16	46	crossed	cross	VERB
admet-613	16	47	the	the	DET
admet-613	16	48	placenta	placenta	NOUN
admet-613	16	49	in	in	ADP
admet-613	16	50	its	its	PRON
admet-613	16	51	active	active	ADJ
admet-613	16	52	form	form	NOUN
admet-613	16	53	.	.	PUNCT
admet-613	17	1	usually	usually	ADV
admet-613	17	2	,	,	PUNCT
admet-613	17	3	a	a	DET
admet-613	17	4	single	single	ADJ
admet-613	17	5	course	course	NOUN
admet-613	17	6	of	of	ADP
admet-613	17	7	betamethasone	betamethasone	PROPN
admet-613	17	8	is	be	AUX
admet-613	17	9	recommended	recommend	VERB
admet-613	17	10	between	between	ADP
admet-613	17	11	24	24	NUM
admet-613	17	12	and	and	CCONJ
admet-613	17	13	33	33	NUM
admet-613	17	14	weeks	week	NOUN
admet-613	17	15	of	of	ADP
admet-613	17	16	gestation	gestation	NOUN
admet-613	17	17	among	among	ADP
admet-613	17	18	pregnant	pregnant	ADJ
admet-613	17	19	women	woman	NOUN
admet-613	17	20	who	who	PRON
admet-613	17	21	are	be	AUX
admet-613	17	22	at	at	ADP
admet-613	17	23	risk	risk	NOUN
admet-613	17	24	of	of	ADP
admet-613	17	25	preterm	preterm	ADJ
admet-613	17	26	delivery	delivery	NOUN
admet-613	17	27	(	(	PUNCT
admet-613	17	28	often	often	ADV
admet-613	17	29	administered	administer	VERB
admet-613	17	30	within	within	ADP
admet-613	17	31	7	7	NUM
admet-613	17	32	days	day	NOUN
admet-613	17	33	)	)	PUNCT
admet-613	17	34	.	.	PUNCT
admet-613	18	1	reports	report	NOUN
admet-613	18	2	suggest	suggest	VERB
admet-613	18	3	that	that	SCONJ
admet-613	18	4	antenatal	antenatal	ADJ
admet-613	18	5	betamethasone	betamethasone	NOUN
admet-613	18	6	increases	increase	VERB
admet-613	18	7	glomerular	glomerular	ADJ
admet-613	18	8	filtration	filtration	NOUN
admet-613	18	9	rate	rate	NOUN
admet-613	18	10	(	(	PUNCT
admet-613	18	11	gfr	gfr	NOUN
admet-613	18	12	)	)	PUNCT
admet-613	18	13	on	on	ADP
admet-613	18	14	day	day	NOUN
admet-613	18	15	3	3	NUM
admet-613	18	16	of	of	ADP
admet-613	18	17	the	the	DET
admet-613	18	18	life	life	NOUN
admet-613	18	19	of	of	ADP
admet-613	18	20	preterm	preterm	ADJ
admet-613	18	21	newborns	newborn	NOUN
admet-613	18	22	[	[	X
admet-613	18	23	2	2	NUM
admet-613	18	24	]	]	PUNCT
admet-613	18	25	.	.	PUNCT
admet-613	19	1	furthermore	furthermore	ADV
admet-613	19	2	,	,	PUNCT
admet-613	19	3	newborns	newborn	NOUN
admet-613	19	4	,	,	PUNCT
admet-613	19	5	especially	especially	ADV
admet-613	19	6	those	those	PRON
admet-613	19	7	born	bear	VERB
admet-613	19	8	prematurely	prematurely	ADV
admet-613	19	9	are	be	AUX
admet-613	19	10	highly	highly	ADV
admet-613	19	11	susceptible	susceptible	ADJ
admet-613	19	12	to	to	ADP
admet-613	19	13	infections	infection	NOUN
admet-613	19	14	due	due	ADP
admet-613	19	15	to	to	ADP
admet-613	19	16	their	their	PRON
admet-613	19	17	immature	immature	ADJ
admet-613	19	18	immune	immune	ADJ
admet-613	19	19	system	system	NOUN
admet-613	19	20	[	[	X
admet-613	19	21	3	3	NUM
admet-613	19	22	]	]	PUNCT
admet-613	19	23	.	.	PUNCT
admet-613	20	1	the	the	DET
admet-613	20	2	cornerstone	cornerstone	NOUN
admet-613	20	3	of	of	ADP
admet-613	20	4	treatment	treatment	NOUN
admet-613	20	5	of	of	ADP
admet-613	20	6	these	these	DET
admet-613	20	7	infections	infection	NOUN
admet-613	20	8	is	be	AUX
admet-613	20	9	the	the	DET
admet-613	20	10	use	use	NOUN
admet-613	20	11	of	of	ADP
admet-613	20	12	antibiotics	antibiotic	NOUN
admet-613	20	13	.	.	PUNCT
admet-613	21	1	amikacin	amikacin	PROPN
admet-613	21	2	is	be	AUX
admet-613	21	3	a	a	DET
admet-613	21	4	commonly	commonly	ADV
admet-613	21	5	prescribed	prescribe	VERB
admet-613	21	6	aminoglycoside	aminoglycoside	ADV
admet-613	21	7	for	for	ADP
admet-613	21	8	empirical	empirical	ADJ
admet-613	21	9	treatment	treatment	NOUN
admet-613	21	10	of	of	ADP
admet-613	21	11	gram	gram	NOUN
admet-613	21	12	-	-	PUNCT
admet-613	21	13	negative	negative	ADJ
admet-613	21	14	bacterial	bacterial	ADJ
admet-613	21	15	infections	infection	NOUN
admet-613	21	16	in	in	ADP
admet-613	21	17	neonatal	neonatal	ADJ
admet-613	21	18	intensive	intensive	ADJ
admet-613	21	19	care	care	NOUN
admet-613	21	20	units	unit	NOUN
admet-613	21	21	in	in	ADP
admet-613	21	22	most	most	ADJ
admet-613	21	23	developing	develop	VERB
admet-613	21	24	countries	country	NOUN
admet-613	21	25	[	[	X
admet-613	21	26	4	4	NUM
admet-613	21	27	]	]	PUNCT
admet-613	21	28	.	.	PUNCT
admet-613	22	1	aminoglycosides	aminoglycoside	NOUN
admet-613	22	2	are	be	AUX
admet-613	22	3	known	know	VERB
admet-613	22	4	to	to	PART
admet-613	22	5	be	be	AUX
admet-613	22	6	excreted	excrete	VERB
admet-613	22	7	almost	almost	ADV
admet-613	22	8	solely	solely	ADV
admet-613	22	9	via	via	ADP
admet-613	22	10	the	the	DET
admet-613	22	11	kidneys	kidney	NOUN
admet-613	23	1	[	[	X
admet-613	23	2	5	5	NUM
admet-613	23	3	]	]	PUNCT
admet-613	23	4	.	.	PUNCT
admet-613	24	1	there	there	PRON
admet-613	24	2	is	be	VERB
admet-613	24	3	the	the	DET
admet-613	24	4	likelihood	likelihood	NOUN
admet-613	24	5	,	,	PUNCT
admet-613	24	6	however	however	ADV
admet-613	24	7	,	,	PUNCT
admet-613	24	8	that	that	SCONJ
admet-613	24	9	the	the	DET
admet-613	24	10	effect	effect	NOUN
admet-613	24	11	of	of	ADP
admet-613	24	12	corticosteroids	corticosteroid	NOUN
admet-613	24	13	on	on	ADP
admet-613	24	14	gfr	gfr	NOUN
admet-613	24	15	may	may	AUX
admet-613	24	16	ultimately	ultimately	ADV
admet-613	24	17	alter	alter	VERB
admet-613	24	18	serum	serum	NOUN
admet-613	24	19	levels	level	NOUN
admet-613	24	20	of	of	ADP
admet-613	24	21	aminoglycosides	aminoglycoside	NOUN
admet-613	24	22	administered	administer	VERB
admet-613	24	23	to	to	ADP
admet-613	24	24	newborns	newborn	NOUN
admet-613	24	25	.	.	PUNCT
admet-613	25	1	a	a	DET
admet-613	25	2	decrease	decrease	NOUN
admet-613	25	3	in	in	ADP
admet-613	25	4	serum	serum	NOUN
admet-613	25	5	levels	level	NOUN
admet-613	25	6	of	of	ADP
admet-613	25	7	aminoglycosides	aminoglycoside	NOUN
admet-613	25	8	as	as	ADP
admet-613	25	9	a	a	DET
admet-613	25	10	result	result	NOUN
admet-613	25	11	of	of	ADP
admet-613	25	12	alteration	alteration	NOUN
admet-613	25	13	in	in	ADP
admet-613	25	14	gfr	gfr	NOUN
admet-613	25	15	by	by	ADP
admet-613	25	16	corticosteroids	corticosteroid	NOUN
admet-613	25	17	may	may	AUX
admet-613	25	18	lead	lead	VERB
admet-613	25	19	to	to	ADP
admet-613	25	20	selection	selection	NOUN
admet-613	25	21	for	for	ADP
admet-613	25	22	resistant	resistant	ADJ
admet-613	25	23	microorganism	microorganism	NOUN
admet-613	25	24	strains	strain	NOUN
admet-613	25	25	and	and	CCONJ
admet-613	25	26	infection	infection	NOUN
admet-613	25	27	treatment	treatment	NOUN
admet-613	25	28	failure	failure	NOUN
admet-613	25	29	.	.	PUNCT
admet-613	26	1	a	a	DET
admet-613	26	2	previous	previous	ADJ
admet-613	26	3	study	study	NOUN
admet-613	26	4	has	have	AUX
admet-613	26	5	showed	show	VERB
admet-613	26	6	that	that	DET
admet-613	26	7	administration	administration	NOUN
admet-613	26	8	of	of	ADP
admet-613	26	9	betamethasone	betamethasone	PROPN
admet-613	26	10	to	to	ADP
admet-613	26	11	pregnant	pregnant	ADJ
admet-613	26	12	mothers	mother	NOUN
admet-613	26	13	had	have	VERB
admet-613	26	14	no	no	DET
admet-613	26	15	significant	significant	ADJ
admet-613	26	16	effect	effect	NOUN
admet-613	26	17	on	on	ADP
admet-613	26	18	amikacin	amikacin	PROPN
admet-613	26	19	clearance	clearance	NOUN
admet-613	26	20	on	on	ADP
admet-613	26	21	the	the	DET
admet-613	26	22	first	first	ADJ
admet-613	26	23	day	day	NOUN
admet-613	26	24	of	of	ADP
admet-613	26	25	life	life	NOUN
admet-613	26	26	of	of	ADP
admet-613	26	27	preterm	preterm	ADJ
admet-613	26	28	newborns	newborn	NOUN
admet-613	26	29	[	[	X
admet-613	26	30	6	6	NUM
admet-613	26	31	]	]	PUNCT
admet-613	26	32	.	.	PUNCT
admet-613	27	1	in	in	ADP
admet-613	27	2	that	that	DET
admet-613	27	3	study	study	NOUN
admet-613	27	4	,	,	PUNCT
admet-613	27	5	blood	blood	NOUN
admet-613	27	6	samples	sample	NOUN
admet-613	27	7	for	for	ADP
admet-613	27	8	therapeutic	therapeutic	ADJ
admet-613	27	9	drug	drug	NOUN
admet-613	27	10	monitoring	monitoring	NOUN
admet-613	27	11	were	be	AUX
admet-613	27	12	drawn	draw	VERB
admet-613	27	13	40	40	NUM
admet-613	27	14	min	min	NOUN
admet-613	27	15	before	before	ADP
admet-613	27	16	and	and	CCONJ
admet-613	27	17	after	after	ADP
admet-613	27	18	completion	completion	NOUN
admet-613	27	19	of	of	ADP
admet-613	27	20	the	the	DET
admet-613	27	21	second	second	ADJ
admet-613	27	22	dose	dose	NOUN
admet-613	27	23	of	of	ADP
admet-613	27	24	amikacin	amikacin	PROPN
admet-613	27	25	[	[	X
admet-613	27	26	6	6	NUM
admet-613	27	27	]	]	PUNCT
admet-613	27	28	.	.	PUNCT
admet-613	28	1	hence	hence	ADV
admet-613	28	2	,	,	PUNCT
admet-613	28	3	blood	blood	NOUN
admet-613	28	4	samples	sample	NOUN
admet-613	28	5	for	for	ADP
admet-613	28	6	pharmacokinetic	pharmacokinetic	ADJ
admet-613	28	7	analysis	analysis	NOUN
admet-613	28	8	were	be	AUX
admet-613	28	9	taken	take	VERB
admet-613	28	10	between	between	ADP
admet-613	28	11	23	23	NUM
admet-613	28	12	–	–	SYM
admet-613	28	13	43	43	NUM
admet-613	28	14	h	h	NOUN
admet-613	28	15	,	,	PUNCT
admet-613	28	16	according	accord	VERB
admet-613	28	17	to	to	ADP
admet-613	28	18	various	various	ADJ
admet-613	28	19	dosing	dose	VERB
admet-613	28	20	schemes	scheme	NOUN
admet-613	28	21	employed	employ	VERB
admet-613	28	22	in	in	ADP
admet-613	28	23	that	that	DET
admet-613	28	24	study	study	NOUN
admet-613	28	25	.	.	PUNCT
admet-613	29	1	it	it	PRON
admet-613	29	2	is	be	AUX
admet-613	29	3	noteworthy	noteworthy	ADJ
admet-613	29	4	,	,	PUNCT
admet-613	29	5	however	however	ADV
admet-613	29	6	,	,	PUNCT
admet-613	29	7	that	that	SCONJ
admet-613	29	8	another	another	DET
admet-613	29	9	study	study	NOUN
admet-613	29	10	concluded	conclude	VERB
admet-613	29	11	that	that	SCONJ
admet-613	29	12	prenatal	prenatal	ADJ
admet-613	29	13	exposure	exposure	NOUN
admet-613	29	14	to	to	ADP
admet-613	29	15	betamethasone	betamethasone	PROPN
admet-613	29	16	increased	increase	VERB
admet-613	29	17	gfr	gfr	NOUN
admet-613	29	18	;	;	PUNCT
admet-613	29	19	but	but	CCONJ
admet-613	29	20	this	this	DET
admet-613	29	21	effect	effect	NOUN
admet-613	29	22	was	be	AUX
admet-613	29	23	observed	observe	VERB
admet-613	29	24	on	on	ADP
admet-613	29	25	day	day	NOUN
admet-613	29	26	3	3	NUM
admet-613	29	27	(	(	PUNCT
admet-613	29	28	72	72	NUM
admet-613	29	29	h	h	NOUN
admet-613	29	30	)	)	PUNCT
admet-613	29	31	of	of	ADP
admet-613	29	32	the	the	DET
admet-613	29	33	life	life	NOUN
admet-613	29	34	of	of	ADP
admet-613	29	35	preterm	preterm	ADJ
admet-613	29	36	infants	infant	NOUN
admet-613	29	37	[	[	X
admet-613	29	38	2	2	NUM
admet-613	29	39	]	]	PUNCT
admet-613	29	40	.	.	PUNCT
admet-613	30	1	also	also	ADV
admet-613	30	2	considering	consider	VERB
admet-613	30	3	the	the	DET
admet-613	30	4	fact	fact	NOUN
admet-613	30	5	that	that	SCONJ
admet-613	30	6	amikacin	amikacin	PROPN
admet-613	30	7	treatment	treatment	NOUN
admet-613	30	8	for	for	ADP
admet-613	30	9	newborns	newborn	NOUN
admet-613	30	10	with	with	ADP
admet-613	30	11	infection	infection	NOUN
admet-613	30	12	could	could	AUX
admet-613	30	13	range	range	VERB
admet-613	30	14	from	from	ADP
admet-613	30	15	5	5	NUM
admet-613	30	16	–	–	SYM
admet-613	30	17	7	7	NUM
admet-613	30	18	days	day	NOUN
admet-613	30	19	,	,	PUNCT
admet-613	30	20	there	there	PRON
admet-613	30	21	is	be	VERB
admet-613	30	22	the	the	DET
admet-613	30	23	likelihood	likelihood	NOUN
admet-613	30	24	that	that	SCONJ
admet-613	30	25	day	day	NOUN
admet-613	30	26	1	1	NUM
admet-613	30	27	blood	blood	NOUN
admet-613	30	28	samples	sample	NOUN
admet-613	30	29	for	for	ADP
admet-613	30	30	pharmacokinetic	pharmacokinetic	ADJ
admet-613	30	31	(	(	PUNCT
admet-613	30	32	clearance	clearance	NOUN
admet-613	30	33	)	)	PUNCT
admet-613	30	34	estimations	estimation	NOUN
admet-613	30	35	may	may	AUX
admet-613	30	36	not	not	PART
admet-613	30	37	reflect	reflect	VERB
admet-613	30	38	the	the	DET
admet-613	30	39	effect	effect	NOUN
admet-613	30	40	of	of	ADP
admet-613	30	41	prenatal	prenatal	ADJ
admet-613	30	42	administration	administration	NOUN
admet-613	30	43	of	of	ADP
admet-613	30	44	betamethasone	betamethasone	PROPN
admet-613	30	45	on	on	ADP
admet-613	30	46	amikacin	amikacin	PROPN
admet-613	30	47	.	.	PUNCT
admet-613	31	1	we	we	PRON
admet-613	31	2	therefore	therefore	ADV
admet-613	31	3	sought	seek	VERB
admet-613	31	4	to	to	PART
admet-613	31	5	investigate	investigate	VERB
admet-613	31	6	the	the	DET
admet-613	31	7	effect	effect	NOUN
admet-613	31	8	of	of	ADP
admet-613	31	9	pre	pre	NOUN
admet-613	31	10	-	-	NOUN
admet-613	31	11	administration	administration	NOUN
admet-613	31	12	of	of	ADP
admet-613	31	13	betamethasone	betamethasone	PROPN
admet-613	31	14	on	on	ADP
admet-613	31	15	the	the	DET
admet-613	31	16	pharmacokinetics	pharmacokinetic	NOUN
admet-613	31	17	of	of	ADP
admet-613	31	18	amikacin	amikacin	PROPN
admet-613	31	19	using	use	VERB
admet-613	31	20	an	an	DET
admet-613	31	21	animal	animal	NOUN
admet-613	31	22	model	model	NOUN
admet-613	31	23	,	,	PUNCT
admet-613	31	24	where	where	SCONJ
admet-613	31	25	blood	blood	NOUN
admet-613	31	26	samples	sample	NOUN
admet-613	31	27	for	for	ADP
admet-613	31	28	pharmacokinetic	pharmacokinetic	ADJ
admet-613	31	29	estimates	estimate	NOUN
admet-613	31	30	of	of	ADP
admet-613	31	31	amikacin	amikacin	PROPN
admet-613	31	32	were	be	AUX
admet-613	31	33	drawn	draw	VERB
admet-613	31	34	72	72	NUM
admet-613	31	35	h	h	NOUN
admet-613	31	36	after	after	ADP
admet-613	31	37	the	the	DET
admet-613	31	38	last	last	ADJ
admet-613	31	39	dose	dose	NOUN
admet-613	31	40	of	of	ADP
admet-613	31	41	betamethasone	betamethasone	PROPN
admet-613	31	42	.	.	PUNCT
admet-613	32	1	an	an	DET
admet-613	32	2	animal	animal	NOUN
admet-613	32	3	model	model	NOUN
admet-613	32	4	will	will	AUX
admet-613	32	5	provide	provide	VERB
admet-613	32	6	preliminary	preliminary	ADJ
admet-613	32	7	account	account	NOUN
admet-613	32	8	of	of	ADP
admet-613	32	9	possible	possible	ADJ
admet-613	32	10	pharmacokinetic	pharmacokinetic	ADJ
admet-613	32	11	interaction	interaction	NOUN
admet-613	32	12	of	of	ADP
admet-613	32	13	these	these	DET
admet-613	32	14	two	two	NUM
admet-613	32	15	drugs	drug	NOUN
admet-613	32	16	,	,	PUNCT
admet-613	32	17	and	and	CCONJ
admet-613	32	18	serve	serve	VERB
admet-613	32	19	as	as	ADP
admet-613	32	20	a	a	DET
admet-613	32	21	basis	basis	NOUN
admet-613	32	22	for	for	ADP
admet-613	32	23	full	full	ADJ
admet-613	32	24	clinical	clinical	ADJ
admet-613	32	25	studies	study	NOUN
admet-613	32	26	in	in	ADP
admet-613	32	27	humans	human	NOUN
admet-613	32	28	.	.	PUNCT
admet-613	33	1	it	it	PRON
admet-613	33	2	is	be	AUX
admet-613	33	3	noteworthy	noteworthy	ADJ
admet-613	33	4	that	that	SCONJ
admet-613	33	5	the	the	DET
admet-613	33	6	initial	initial	ADJ
admet-613	33	7	experimental	experimental	ADJ
admet-613	33	8	design	design	NOUN
admet-613	33	9	tried	try	VERB
admet-613	33	10	to	to	PART
admet-613	33	11	mimic	mimic	VERB
admet-613	33	12	exactly	exactly	ADV
admet-613	33	13	what	what	PRON
admet-613	33	14	pertains	pertain	VERB
admet-613	33	15	in	in	ADP
admet-613	33	16	humans	human	NOUN
admet-613	33	17	:	:	PUNCT
admet-613	33	18	administration	administration	NOUN
admet-613	33	19	of	of	ADP
admet-613	33	20	betamethasone	betamethasone	PROPN
admet-613	33	21	to	to	ADP
admet-613	33	22	pregnant	pregnant	ADJ
admet-613	33	23	rat	rat	NOUN
admet-613	33	24	,	,	PUNCT
admet-613	33	25	followed	follow	VERB
admet-613	33	26	by	by	ADP
admet-613	33	27	administration	administration	NOUN
admet-613	33	28	of	of	ADP
admet-613	33	29	amikacin	amikacin	PROPN
admet-613	33	30	to	to	ADP
admet-613	33	31	litters	litter	NOUN
admet-613	33	32	,	,	PUNCT
admet-613	33	33	and	and	CCONJ
admet-613	33	34	serial	serial	ADJ
admet-613	33	35	drawing	drawing	NOUN
admet-613	33	36	of	of	ADP
admet-613	33	37	blood	blood	NOUN
admet-613	33	38	from	from	ADP
admet-613	33	39	litters	litter	NOUN
admet-613	33	40	for	for	ADP
admet-613	33	41	pharmacokinetic	pharmacokinetic	ADJ
admet-613	33	42	estimation	estimation	NOUN
admet-613	33	43	.	.	PUNCT
admet-613	34	1	however	however	ADV
admet-613	34	2	,	,	PUNCT
admet-613	34	3	this	this	DET
admet-613	34	4	approach	approach	NOUN
admet-613	34	5	had	have	VERB
admet-613	34	6	ethical	ethical	ADJ
admet-613	34	7	(	(	PUNCT
admet-613	34	8	drawing	draw	VERB
admet-613	34	9	blood	blood	NOUN
admet-613	34	10	5	5	NUM
admet-613	34	11	times	time	NOUN
admet-613	34	12	from	from	ADP
admet-613	34	13	rat	rat	NOUN
admet-613	34	14	litter	litter	NOUN
admet-613	34	15	)	)	PUNCT
admet-613	34	16	and	and	CCONJ
admet-613	34	17	operational	operational	ADJ
admet-613	34	18	implications	implication	NOUN
admet-613	34	19	(	(	PUNCT
admet-613	34	20	low	low	ADJ
admet-613	34	21	blood	blood	NOUN
admet-613	34	22	volumes	volume	NOUN
admet-613	34	23	)	)	PUNCT
admet-613	34	24	.	.	PUNCT
admet-613	35	1	therefore	therefore	ADV
admet-613	35	2	,	,	PUNCT
admet-613	35	3	the	the	DET
admet-613	35	4	current	current	ADJ
admet-613	35	5	study	study	NOUN
admet-613	35	6	had	have	VERB
admet-613	35	7	to	to	PART
admet-613	35	8	assess	assess	VERB
admet-613	35	9	possibility	possibility	NOUN
admet-613	35	10	of	of	ADP
admet-613	35	11	interaction	interaction	NOUN
admet-613	35	12	between	between	ADP
admet-613	35	13	amikacin	amikacin	PROPN
admet-613	35	14	and	and	CCONJ
admet-613	35	15	betamethasone	betamethasone	NOUN
admet-613	35	16	using	use	VERB
admet-613	35	17	young	young	ADJ
admet-613	35	18	adult	adult	NOUN
admet-613	35	19	rats	rat	NOUN
admet-613	35	20	.	.	PUNCT
admet-613	36	1	experimental	experimental	ADJ
admet-613	36	2	experimental	experimental	ADJ
admet-613	36	3	animals	animal	NOUN
admet-613	36	4	the	the	DET
admet-613	36	5	study	study	NOUN
admet-613	36	6	was	be	AUX
admet-613	36	7	approved	approve	VERB
admet-613	36	8	by	by	ADP
admet-613	36	9	the	the	DET
admet-613	36	10	ethical	ethical	ADJ
admet-613	36	11	and	and	CCONJ
admet-613	36	12	protocol	protocol	NOUN
admet-613	36	13	review	review	PROPN
admet-613	36	14	committee	committee	NOUN
admet-613	36	15	of	of	ADP
admet-613	36	16	the	the	DET
admet-613	36	17	university	university	PROPN
admet-613	36	18	of	of	ADP
admet-613	36	19	ghana	ghana	PROPN
admet-613	36	20	medical	medical	PROPN
admet-613	36	21	school	school	PROPN
admet-613	36	22	(	(	PUNCT
admet-613	36	23	protocol	protocol	NOUN
admet-613	37	1	i	i	PROPN
admet-613	37	2	d	d	PROPN
admet-613	37	3	:	:	PUNCT
admet-613	37	4	ms	ms	PROPN
admet-613	37	5	-	-	PUNCT
admet-613	37	6	et	et	NOUN
admet-613	37	7	/	/	SYM
admet-613	37	8	m.8	m.8	NOUN
admet-613	37	9	-	-	ADJ
admet-613	37	10	p.5.3	p.5.3	ADJ
admet-613	37	11	)	)	PUNCT
admet-613	37	12	.	.	PUNCT
admet-613	38	1	the	the	DET
admet-613	38	2	animals	animal	NOUN
admet-613	38	3	were	be	AUX
admet-613	38	4	handled	handle	VERB
admet-613	38	5	using	use	VERB
admet-613	38	6	procedures	procedure	NOUN
admet-613	38	7	and	and	CCONJ
admet-613	38	8	techniques	technique	NOUN
admet-613	38	9	in	in	ADP
admet-613	38	10	accordance	accordance	NOUN
admet-613	38	11	with	with	ADP
admet-613	38	12	the	the	DET
admet-613	38	13	guidelines	guideline	NOUN
admet-613	38	14	published	publish	VERB
admet-613	38	15	by	by	ADP
admet-613	38	16	the	the	DET
admet-613	38	17	national	national	PROPN
admet-613	38	18	institute	institute	PROPN
admet-613	38	19	of	of	ADP
admet-613	38	20	health	health	PROPN
admet-613	38	21	for	for	ADP
admet-613	38	22	the	the	DET
admet-613	38	23	care	care	NOUN
admet-613	38	24	of	of	ADP
admet-613	38	25	laboratory	laboratory	NOUN
admet-613	38	26	animals	animal	NOUN
admet-613	38	27	[	[	X
admet-613	38	28	7	7	NUM
admet-613	38	29	]	]	PUNCT
admet-613	38	30	.	.	PUNCT
admet-613	39	1	twelve	twelve	NUM
admet-613	39	2	(	(	PUNCT
admet-613	39	3	12	12	NUM
admet-613	39	4	)	)	PUNCT
admet-613	39	5	healthy	healthy	ADJ
admet-613	39	6	male	male	NOUN
admet-613	39	7	sprague	sprague	NOUN
admet-613	39	8	-	-	PUNCT
admet-613	39	9	dawley	dawley	NOUN
admet-613	39	10	(	(	PUNCT
admet-613	39	11	sd	sd	NOUN
admet-613	39	12	)	)	PUNCT
admet-613	39	13	rats	rat	NOUN
admet-613	39	14	(	(	PUNCT
admet-613	39	15	7	7	NUM
admet-613	39	16	8	8	NUM
admet-613	39	17	weeks	week	NOUN
admet-613	39	18	old	old	ADJ
admet-613	39	19	,	,	PUNCT
admet-613	39	20	weighing	weigh	VERB
admet-613	39	21	between	between	ADP
admet-613	39	22	200	200	NUM
admet-613	39	23	–	–	SYM
admet-613	39	24	250	250	NUM
admet-613	39	25	g	g	NOUN
admet-613	39	26	)	)	PUNCT
admet-613	39	27	were	be	AUX
admet-613	39	28	obtained	obtain	VERB
admet-613	39	29	and	and	CCONJ
admet-613	39	30	kept	keep	VERB
admet-613	39	31	under	under	ADP
admet-613	39	32	suitable	suitable	ADJ
admet-613	39	33	conditions	condition	NOUN
admet-613	39	34	throughout	throughout	ADP
admet-613	39	35	the	the	DET
admet-613	39	36	experimental	experimental	ADJ
admet-613	39	37	process	process	NOUN
admet-613	39	38	.	.	PUNCT
admet-613	40	1	the	the	DET
admet-613	40	2	animal	animal	NOUN
admet-613	40	3	model	model	NOUN
admet-613	40	4	used	use	VERB
admet-613	40	5	only	only	ADV
admet-613	40	6	male	male	ADJ
admet-613	40	7	rats	rat	NOUN
admet-613	40	8	to	to	PART
admet-613	40	9	exclude	exclude	VERB
admet-613	40	10	sex	sex	NOUN
admet-613	40	11	as	as	ADP
admet-613	40	12	a	a	DET
admet-613	40	13	confounding	confound	VERB
admet-613	40	14	factor	factor	NOUN
admet-613	40	15	.	.	PUNCT
admet-613	41	1	a	a	DET
admet-613	41	2	controlled	control	VERB
admet-613	41	3	breeding	breeding	NOUN
admet-613	41	4	room	room	NOUN
admet-613	41	5	of	of	ADP
admet-613	41	6	temperature	temperature	NOUN
admet-613	41	7	26	26	NUM
admet-613	41	8	admet	admet	NOUN
admet-613	41	9	&	&	CCONJ
admet-613	41	10	dmpk	dmpk	PROPN
admet-613	41	11	6(4	6(4	PROPN
admet-613	41	12	)	)	PUNCT
admet-613	41	13	(	(	PUNCT
admet-613	41	14	2018	2018	NUM
admet-613	41	15	)	)	PUNCT
admet-613	41	16	279	279	NUM
admet-613	41	17	-	-	SYM
admet-613	41	18	283	283	NUM
admet-613	41	19	betamethasone	betamethasone	NOUN
admet-613	41	20	affects	affect	VERB
admet-613	41	21	the	the	DET
admet-613	41	22	disposition	disposition	NOUN
admet-613	41	23	of	of	ADP
admet-613	41	24	amikacin	amikacin	PROPN
admet-613	41	25	doi	doi	NOUN
admet-613	41	26	:	:	PUNCT
admet-613	41	27	10.5599	10.5599	NUM
admet-613	41	28	/	/	SYM
admet-613	41	29	admet.613	admet.613	PROPN
admet-613	41	30	281	281	NUM
admet-613	41	31	±	±	NUM
admet-613	41	32	2	2	NUM
admet-613	41	33	°	°	ADP
admet-613	41	34	c	c	NOUN
admet-613	41	35	with	with	ADP
admet-613	41	36	a	a	DET
admet-613	41	37	12	12	NUM
admet-613	41	38	h	h	NOUN
admet-613	41	39	light	light	ADJ
admet-613	41	40	/	/	SYM
admet-613	41	41	dark	dark	ADJ
admet-613	41	42	cycle	cycle	NOUN
admet-613	41	43	was	be	AUX
admet-613	41	44	used	use	VERB
admet-613	41	45	.	.	PUNCT
admet-613	42	1	the	the	DET
admet-613	42	2	sd	sd	NOUN
admet-613	42	3	rats	rat	NOUN
admet-613	42	4	were	be	AUX
admet-613	42	5	maintained	maintain	VERB
admet-613	42	6	on	on	ADP
admet-613	42	7	local	local	ADJ
admet-613	42	8	animal	animal	NOUN
admet-613	42	9	feed	feed	NOUN
admet-613	42	10	and	and	CCONJ
admet-613	42	11	water	water	NOUN
admet-613	42	12	ad	ad	NOUN
admet-613	42	13	libitum	libitum	PROPN
admet-613	42	14	.	.	PUNCT
admet-613	43	1	the	the	DET
admet-613	43	2	animals	animal	NOUN
admet-613	43	3	were	be	AUX
admet-613	43	4	put	put	VERB
admet-613	43	5	into	into	ADP
admet-613	43	6	two	two	NUM
admet-613	43	7	(	(	PUNCT
admet-613	43	8	2	2	NUM
admet-613	43	9	)	)	PUNCT
admet-613	43	10	groups	group	NOUN
admet-613	43	11	of	of	ADP
admet-613	43	12	six	six	NUM
admet-613	43	13	(	(	PUNCT
admet-613	43	14	6	6	NUM
admet-613	43	15	)	)	PUNCT
admet-613	43	16	–	–	PUNCT
admet-613	43	17	group	group	NOUN
admet-613	43	18	1	1	NUM
admet-613	43	19	and	and	CCONJ
admet-613	43	20	group	group	NOUN
admet-613	43	21	2	2	NUM
admet-613	43	22	.	.	PUNCT
admet-613	44	1	the	the	DET
admet-613	44	2	animals	animal	NOUN
admet-613	44	3	in	in	ADP
admet-613	44	4	group	group	NOUN
admet-613	44	5	1	1	NUM
admet-613	44	6	(	(	PUNCT
admet-613	44	7	test	test	NOUN
admet-613	44	8	)	)	PUNCT
admet-613	44	9	were	be	AUX
admet-613	44	10	first	first	ADV
admet-613	44	11	administered	administer	VERB
admet-613	44	12	with	with	ADP
admet-613	44	13	standard	standard	ADJ
admet-613	44	14	doses	dose	NOUN
admet-613	44	15	of	of	ADP
admet-613	44	16	betamethasone	betamethasone	NOUN
admet-613	44	17	and	and	CCONJ
admet-613	44	18	thereafter	thereafter	ADV
admet-613	44	19	,	,	PUNCT
admet-613	44	20	standard	standard	ADJ
admet-613	44	21	doses	dose	NOUN
admet-613	44	22	of	of	ADP
admet-613	44	23	amikacin	amikacin	PROPN
admet-613	44	24	.	.	PUNCT
admet-613	45	1	animals	animal	NOUN
admet-613	45	2	in	in	ADP
admet-613	45	3	group	group	NOUN
admet-613	45	4	2	2	NUM
admet-613	45	5	(	(	PUNCT
admet-613	45	6	control	control	NOUN
admet-613	45	7	)	)	PUNCT
admet-613	45	8	were	be	AUX
admet-613	45	9	treated	treat	VERB
admet-613	45	10	in	in	ADP
admet-613	45	11	a	a	DET
admet-613	45	12	similar	similar	ADJ
admet-613	45	13	manner	manner	NOUN
admet-613	45	14	except	except	SCONJ
admet-613	45	15	replacing	replace	VERB
admet-613	45	16	betamethasone	betamethasone	NOUN
admet-613	45	17	with	with	ADP
admet-613	45	18	normal	normal	ADJ
admet-613	45	19	saline	saline	NOUN
admet-613	45	20	.	.	PUNCT
admet-613	46	1	drug	drug	NOUN
admet-613	46	2	administration	administration	PROPN
admet-613	46	3	a	a	DET
admet-613	46	4	dose	dose	NOUN
admet-613	46	5	of	of	ADP
admet-613	46	6	0.15	0.15	NUM
admet-613	46	7	mg	mg	PROPN
admet-613	46	8	kg	kg	INTJ
admet-613	46	9	-1	-1	X
admet-613	46	10	of	of	ADP
admet-613	46	11	betamethasone	betamethasone	PROPN
admet-613	46	12	(	(	PUNCT
admet-613	46	13	diprofos	diprofos	PROPN
admet-613	46	14	*	*	NOUN
admet-613	46	15	,	,	PUNCT
admet-613	46	16	schering	schering	NOUN
admet-613	46	17	-	-	PUNCT
admet-613	46	18	plough	plough	NOUN
admet-613	46	19	,	,	PUNCT
admet-613	46	20	brussels	brussels	PROPN
admet-613	46	21	,	,	PUNCT
admet-613	46	22	belgium	belgium	PROPN
admet-613	46	23	)	)	PUNCT
admet-613	46	24	was	be	AUX
admet-613	46	25	administered	administer	VERB
admet-613	46	26	intraperitoneally	intraperitoneally	ADV
admet-613	46	27	to	to	ADP
admet-613	46	28	the	the	DET
admet-613	46	29	test	test	NOUN
admet-613	46	30	group	group	NOUN
admet-613	46	31	every	every	DET
admet-613	46	32	24	24	NUM
admet-613	46	33	h	h	NOUN
admet-613	46	34	for	for	ADP
admet-613	46	35	3	3	NUM
admet-613	46	36	consecutive	consecutive	ADJ
admet-613	46	37	days	day	NOUN
admet-613	46	38	.	.	PUNCT
admet-613	47	1	betamethasone	betamethasone	PROPN
admet-613	47	2	dose	dose	PROPN
admet-613	47	3	was	be	AUX
admet-613	47	4	based	base	VERB
admet-613	47	5	on	on	ADP
admet-613	47	6	allometric	allometric	ADJ
admet-613	47	7	scaling	scaling	NOUN
admet-613	47	8	from	from	ADP
admet-613	47	9	humans	human	NOUN
admet-613	47	10	(	(	PUNCT
admet-613	47	11	prenatal	prenatal	ADJ
admet-613	47	12	doses	dose	NOUN
admet-613	47	13	of	of	ADP
admet-613	47	14	12	12	NUM
admet-613	47	15	mg	mg	NOUN
admet-613	47	16	given	give	VERB
admet-613	47	17	every	every	DET
admet-613	47	18	24	24	NUM
admet-613	47	19	h	h	NOUN
admet-613	47	20	for	for	ADP
admet-613	47	21	2	2	NUM
admet-613	47	22	-3	-3	PUNCT
admet-613	47	23	days	day	NOUN
admet-613	47	24	)	)	PUNCT
admet-613	47	25	to	to	ADP
admet-613	47	26	rats	rat	NOUN
admet-613	47	27	.	.	PUNCT
admet-613	48	1	after	after	ADP
admet-613	48	2	this	this	PRON
admet-613	48	3	,	,	PUNCT
admet-613	48	4	a	a	DET
admet-613	48	5	dose	dose	NOUN
admet-613	48	6	of	of	ADP
admet-613	48	7	10	10	NUM
admet-613	48	8	mg	mg	NOUN
admet-613	48	9	kg	kg	INTJ
admet-613	48	10	-1	-1	ADP
admet-613	48	11	of	of	ADP
admet-613	48	12	amikacin	amikacin	PROPN
admet-613	48	13	(	(	PUNCT
admet-613	48	14	amikin	amikin	PROPN
admet-613	48	15	®	®	PROPN
admet-613	48	16	,	,	PUNCT
admet-613	48	17	bristol	bristol	NOUN
admet-613	48	18	-	-	PUNCT
admet-613	48	19	myers	myer	NOUN
admet-613	48	20	pharmaceuticals	pharmaceutical	NOUN
admet-613	48	21	,	,	PUNCT
admet-613	48	22	middlesex	middlesex	NOUN
admet-613	48	23	,	,	PUNCT
admet-613	48	24	england	england	PROPN
admet-613	48	25	)	)	PUNCT
admet-613	48	26	was	be	AUX
admet-613	48	27	administered	administer	VERB
admet-613	48	28	intraperitoneally	intraperitoneally	ADV
admet-613	48	29	to	to	ADP
admet-613	48	30	the	the	DET
admet-613	48	31	rats	rat	NOUN
admet-613	48	32	every	every	DET
admet-613	48	33	24	24	NUM
admet-613	48	34	h	h	NOUN
admet-613	48	35	for	for	ADP
admet-613	48	36	3	3	NUM
admet-613	48	37	consecutive	consecutive	ADJ
admet-613	48	38	days	day	NOUN
admet-613	48	39	.	.	PUNCT
admet-613	49	1	of	of	ADP
admet-613	49	2	note	note	NOUN
admet-613	49	3	,	,	PUNCT
admet-613	49	4	similar	similar	ADJ
admet-613	49	5	amikacin	amikacin	NOUN
admet-613	49	6	dosing	dose	VERB
admet-613	49	7	in	in	ADP
admet-613	49	8	rats	rat	NOUN
admet-613	49	9	has	have	AUX
admet-613	49	10	been	be	AUX
admet-613	49	11	reported	report	VERB
admet-613	49	12	elsewhere	elsewhere	ADV
admet-613	49	13	[	[	X
admet-613	49	14	8	8	NUM
admet-613	49	15	]	]	PUNCT
admet-613	49	16	.	.	PUNCT
admet-613	50	1	normal	normal	ADJ
admet-613	50	2	saline	saline	NOUN
admet-613	50	3	was	be	AUX
admet-613	50	4	administered	administer	VERB
admet-613	50	5	intraperitoneally	intraperitoneally	ADV
admet-613	50	6	to	to	ADP
admet-613	50	7	rats	rat	NOUN
admet-613	50	8	in	in	ADP
admet-613	50	9	group	group	NOUN
admet-613	50	10	2	2	NUM
admet-613	50	11	,	,	PUNCT
admet-613	50	12	using	use	VERB
admet-613	50	13	same	same	ADJ
admet-613	50	14	volume	volume	NOUN
admet-613	50	15	per	per	ADP
admet-613	50	16	weight	weight	NOUN
admet-613	50	17	administration	administration	NOUN
admet-613	50	18	as	as	ADP
admet-613	50	19	with	with	ADP
admet-613	50	20	betamethasone	betamethasone	NOUN
admet-613	50	21	.	.	PUNCT
admet-613	51	1	the	the	DET
admet-613	51	2	normal	normal	ADJ
admet-613	51	3	saline	saline	NOUN
admet-613	51	4	was	be	AUX
admet-613	51	5	administered	administer	VERB
admet-613	51	6	to	to	AUX
admet-613	51	7	sd	sd	NOUN
admet-613	51	8	rats	rat	NOUN
admet-613	51	9	for	for	ADP
admet-613	51	10	3	3	NUM
admet-613	51	11	consecutive	consecutive	ADJ
admet-613	51	12	days	day	NOUN
admet-613	51	13	.	.	PUNCT
admet-613	52	1	afterwards	afterwards	ADV
admet-613	52	2	,	,	PUNCT
admet-613	52	3	a	a	DET
admet-613	52	4	dose	dose	NOUN
admet-613	52	5	of	of	ADP
admet-613	52	6	10	10	NUM
admet-613	52	7	mg	mg	PROPN
admet-613	52	8	kg-1	kg-1	NOUN
admet-613	52	9	of	of	ADP
admet-613	52	10	amikacin	amikacin	PROPN
admet-613	52	11	was	be	AUX
admet-613	52	12	administered	administer	VERB
admet-613	52	13	via	via	ADP
admet-613	52	14	the	the	DET
admet-613	52	15	intraperitoneal	intraperitoneal	ADJ
admet-613	52	16	route	route	NOUN
admet-613	52	17	every	every	DET
admet-613	52	18	24	24	NUM
admet-613	52	19	h	h	NOUN
admet-613	52	20	for	for	ADP
admet-613	52	21	3	3	NUM
admet-613	52	22	consecutive	consecutive	ADJ
admet-613	52	23	days	day	NOUN
admet-613	52	24	.	.	PUNCT
admet-613	53	1	blood	blood	NOUN
admet-613	53	2	sample	sample	NOUN
admet-613	53	3	collection	collection	NOUN
admet-613	53	4	and	and	CCONJ
admet-613	53	5	estimation	estimation	NOUN
admet-613	53	6	of	of	ADP
admet-613	53	7	serum	serum	NOUN
admet-613	53	8	amikacin	amikacin	PROPN
admet-613	53	9	level	level	NOUN
admet-613	53	10	tail	tail	NOUN
admet-613	53	11	vein	vein	VERB
admet-613	53	12	blood	blood	NOUN
admet-613	53	13	samples	sample	NOUN
admet-613	53	14	were	be	AUX
admet-613	53	15	taken	take	VERB
admet-613	53	16	following	follow	VERB
admet-613	53	17	the	the	DET
admet-613	53	18	fourth	fourth	ADJ
admet-613	53	19	dose	dose	NOUN
admet-613	53	20	(	(	PUNCT
admet-613	53	21	72	72	NUM
admet-613	53	22	h	h	NOUN
admet-613	53	23	)	)	PUNCT
admet-613	53	24	of	of	ADP
admet-613	53	25	amikacin	amikacin	PROPN
admet-613	53	26	after	after	ADP
admet-613	53	27	0.5	0.5	NUM
admet-613	53	28	,	,	PUNCT
admet-613	53	29	1	1	NUM
admet-613	53	30	,	,	PUNCT
admet-613	53	31	2	2	NUM
admet-613	53	32	,	,	PUNCT
admet-613	53	33	4	4	NUM
admet-613	53	34	and	and	CCONJ
admet-613	53	35	8	8	NUM
admet-613	53	36	h	h	NOUN
admet-613	53	37	,	,	PUNCT
admet-613	53	38	for	for	ADP
admet-613	53	39	rats	rat	NOUN
admet-613	53	40	in	in	ADP
admet-613	53	41	groups	group	NOUN
admet-613	53	42	1	1	NUM
admet-613	53	43	and	and	CCONJ
admet-613	53	44	2	2	NUM
admet-613	53	45	.	.	X
admet-613	53	46	blood	blood	NOUN
admet-613	53	47	samples	sample	NOUN
admet-613	53	48	were	be	AUX
admet-613	53	49	collected	collect	VERB
admet-613	53	50	into	into	ADP
admet-613	53	51	microtainer	microtainer	ADJ
admet-613	53	52	gel	gel	NOUN
admet-613	53	53	tubes	tube	NOUN
admet-613	53	54	and	and	CCONJ
admet-613	53	55	centrifuged	centrifuge	VERB
admet-613	53	56	at	at	ADP
admet-613	53	57	1,500	1,500	NUM
admet-613	53	58	rpm	rpm	NOUN
admet-613	53	59	for	for	ADP
admet-613	53	60	10	10	NUM
admet-613	53	61	min	min	NOUN
admet-613	53	62	to	to	PART
admet-613	53	63	obtain	obtain	VERB
admet-613	53	64	serum	serum	NOUN
admet-613	53	65	.	.	PUNCT
admet-613	54	1	samples	sample	NOUN
admet-613	54	2	from	from	ADP
admet-613	54	3	sd	sd	ADP
admet-613	54	4	rats	rat	NOUN
admet-613	54	5	were	be	AUX
admet-613	54	6	pooled	pool	VERB
admet-613	54	7	as	as	ADP
admet-613	54	8	a	a	DET
admet-613	54	9	result	result	NOUN
admet-613	54	10	of	of	ADP
admet-613	54	11	low	low	ADJ
admet-613	54	12	serum	serum	NOUN
admet-613	54	13	volume	volume	NOUN
admet-613	54	14	required	require	VERB
admet-613	54	15	for	for	ADP
admet-613	54	16	assay	assay	NOUN
admet-613	54	17	.	.	PUNCT
admet-613	55	1	therefore	therefore	ADV
admet-613	55	2	,	,	PUNCT
admet-613	55	3	one	one	NUM
admet-613	55	4	pooled	pool	VERB
admet-613	55	5	-	-	PUNCT
admet-613	55	6	sample	sample	NOUN
admet-613	55	7	was	be	AUX
admet-613	55	8	obtained	obtain	VERB
admet-613	55	9	for	for	ADP
admet-613	55	10	each	each	DET
admet-613	55	11	time	time	NOUN
admet-613	55	12	point	point	NOUN
admet-613	55	13	for	for	ADP
admet-613	55	14	groups	group	NOUN
admet-613	55	15	1	1	NUM
admet-613	55	16	and	and	CCONJ
admet-613	55	17	2	2	NUM
admet-613	55	18	.	.	PUNCT
admet-613	56	1	usually	usually	ADV
admet-613	56	2	,	,	PUNCT
admet-613	56	3	challenges	challenge	NOUN
admet-613	56	4	associated	associate	VERB
admet-613	56	5	with	with	ADP
admet-613	56	6	low	low	ADJ
admet-613	56	7	sample	sample	NOUN
admet-613	56	8	volume	volume	NOUN
admet-613	56	9	during	during	ADP
admet-613	56	10	pharmacokinetic	pharmacokinetic	ADJ
admet-613	56	11	studies	study	NOUN
admet-613	56	12	can	can	AUX
admet-613	56	13	be	be	AUX
admet-613	56	14	circumvented	circumvent	VERB
admet-613	56	15	by	by	ADP
admet-613	56	16	sample	sample	NOUN
admet-613	56	17	-	-	PUNCT
admet-613	56	18	pooling	pooling	NOUN
admet-613	56	19	,	,	PUNCT
admet-613	56	20	which	which	PRON
admet-613	56	21	will	will	AUX
admet-613	56	22	not	not	PART
admet-613	56	23	alter	alter	VERB
admet-613	56	24	eventual	eventual	ADJ
admet-613	56	25	pharmacokinetic	pharmacokinetic	ADJ
admet-613	56	26	estimation	estimation	NOUN
admet-613	56	27	[	[	X
admet-613	56	28	9	9	NUM
admet-613	56	29	]	]	PUNCT
admet-613	56	30	.	.	PUNCT
admet-613	57	1	fluorescence	fluorescence	PROPN
admet-613	57	2	polarization	polarization	PROPN
admet-613	57	3	immunoassay	immunoassay	PROPN
admet-613	57	4	(	(	PUNCT
admet-613	57	5	fpia	fpia	PROPN
admet-613	57	6	)	)	PUNCT
admet-613	57	7	,	,	PUNCT
admet-613	57	8	using	use	VERB
admet-613	57	9	cobas	cobas	PROPN
admet-613	57	10	integra	integra	ADJ
admet-613	57	11	®	®	NOUN
admet-613	57	12	400	400	NUM
admet-613	57	13	(	(	PUNCT
admet-613	57	14	roche	roche	PROPN
admet-613	57	15	diagnostic	diagnostic	PROPN
admet-613	57	16	limited	limit	VERB
admet-613	57	17	,	,	PUNCT
admet-613	57	18	basel	basel	PROPN
admet-613	57	19	,	,	PUNCT
admet-613	57	20	switzerland	switzerland	PROPN
admet-613	57	21	)	)	PUNCT
admet-613	57	22	as	as	SCONJ
admet-613	57	23	previously	previously	ADV
admet-613	57	24	described	describe	VERB
admet-613	57	25	[	[	X
admet-613	57	26	10	10	NUM
admet-613	57	27	]	]	PUNCT
admet-613	57	28	was	be	AUX
admet-613	57	29	the	the	DET
admet-613	57	30	assay	assay	NOUN
admet-613	57	31	used	use	VERB
admet-613	57	32	in	in	ADP
admet-613	57	33	determining	determine	VERB
admet-613	57	34	serum	serum	NOUN
admet-613	57	35	amikacin	amikacin	PROPN
admet-613	57	36	levels	level	NOUN
admet-613	57	37	.	.	PUNCT
admet-613	58	1	the	the	DET
admet-613	58	2	principle	principle	NOUN
admet-613	58	3	behind	behind	ADP
admet-613	58	4	fpia	fpia	PROPN
admet-613	58	5	is	be	AUX
admet-613	58	6	competition	competition	NOUN
admet-613	58	7	for	for	ADP
admet-613	58	8	antibody	antibody	NOUN
admet-613	58	9	binding	bind	VERB
admet-613	58	10	sites	site	NOUN
admet-613	58	11	between	between	ADP
admet-613	58	12	drug	drug	NOUN
admet-613	58	13	in	in	ADP
admet-613	58	14	sample	sample	NOUN
admet-613	58	15	and	and	CCONJ
admet-613	58	16	drug	drug	NOUN
admet-613	58	17	labeled	label	VERB
admet-613	58	18	with	with	ADP
admet-613	58	19	an	an	DET
admet-613	58	20	enzyme	enzyme	NOUN
admet-613	58	21	.	.	PUNCT
admet-613	59	1	the	the	DET
admet-613	59	2	coefficient	coefficient	NOUN
admet-613	59	3	of	of	ADP
admet-613	59	4	variation	variation	NOUN
admet-613	59	5	over	over	ADP
admet-613	59	6	the	the	DET
admet-613	59	7	entire	entire	ADJ
admet-613	59	8	calibration	calibration	NOUN
admet-613	59	9	range	range	NOUN
admet-613	59	10	during	during	ADP
admet-613	59	11	assay	assay	NOUN
admet-613	59	12	for	for	ADP
admet-613	59	13	amikacin	amikacin	PROPN
admet-613	59	14	was	be	AUX
admet-613	59	15	less	less	ADJ
admet-613	59	16	than	than	ADP
admet-613	59	17	4	4	NUM
admet-613	59	18	%	%	NOUN
admet-613	59	19	.	.	PUNCT
admet-613	60	1	pharmacokinetic	pharmacokinetic	ADJ
admet-613	60	2	analysis	analysis	NOUN
admet-613	60	3	estimation	estimation	NOUN
admet-613	60	4	of	of	ADP
admet-613	60	5	pharmacokinetic	pharmacokinetic	ADJ
admet-613	60	6	parameters	parameter	NOUN
admet-613	60	7	of	of	ADP
admet-613	60	8	amikacin	amikacin	PROPN
admet-613	60	9	in	in	ADP
admet-613	60	10	the	the	DET
admet-613	60	11	two	two	NUM
admet-613	60	12	groups	group	NOUN
admet-613	60	13	was	be	AUX
admet-613	60	14	by	by	ADP
admet-613	60	15	a	a	DET
admet-613	60	16	non	non	ADJ
admet-613	60	17	-	-	ADJ
admet-613	60	18	compartmental	compartmental	ADJ
admet-613	60	19	analytical	analytical	ADJ
admet-613	60	20	approach	approach	NOUN
admet-613	60	21	.	.	PUNCT
admet-613	61	1	the	the	DET
admet-613	61	2	linear	linear	PROPN
admet-613	61	3	trapezoidal	trapezoidal	ADJ
admet-613	61	4	rule	rule	NOUN
admet-613	61	5	was	be	AUX
admet-613	61	6	used	use	VERB
admet-613	61	7	in	in	ADP
admet-613	61	8	extrapolating	extrapolate	VERB
admet-613	61	9	area	area	NOUN
admet-613	61	10	under	under	ADP
admet-613	61	11	the	the	DET
admet-613	61	12	concentrationtime	concentrationtime	ADJ
admet-613	61	13	curves	curve	NOUN
admet-613	61	14	(	(	PUNCT
admet-613	61	15	aucs	aucs	NOUN
admet-613	61	16	)	)	PUNCT
admet-613	61	17	for	for	ADP
admet-613	61	18	the	the	DET
admet-613	61	19	two	two	NUM
admet-613	61	20	groups	group	NOUN
admet-613	61	21	.	.	PUNCT
admet-613	62	1	aucs	aucs	PROPN
admet-613	62	2	were	be	AUX
admet-613	62	3	from	from	ADP
admet-613	62	4	time	time	NOUN
admet-613	62	5	0	0	NUM
admet-613	62	6	h	h	NOUN
admet-613	62	7	till	till	SCONJ
admet-613	62	8	the	the	DET
admet-613	62	9	last	last	ADJ
admet-613	62	10	measurement	measurement	NOUN
admet-613	62	11	point	point	NOUN
admet-613	62	12	(	(	PUNCT
admet-613	62	13	8	8	NUM
admet-613	62	14	h	h	NOUN
admet-613	62	15	)	)	PUNCT
admet-613	62	16	.	.	PUNCT
admet-613	63	1	elimination	elimination	NOUN
admet-613	63	2	rate	rate	NOUN
admet-613	63	3	constant	constant	ADJ
admet-613	63	4	(	(	PUNCT
admet-613	63	5	ke	ke	NOUN
admet-613	63	6	)	)	PUNCT
admet-613	63	7	was	be	AUX
admet-613	63	8	assessed	assess	VERB
admet-613	63	9	by	by	ADP
admet-613	63	10	linear	linear	ADJ
admet-613	63	11	regression	regression	NOUN
admet-613	63	12	of	of	ADP
admet-613	63	13	the	the	DET
admet-613	63	14	terminal	terminal	ADJ
admet-613	63	15	part	part	NOUN
admet-613	63	16	of	of	ADP
admet-613	63	17	a	a	DET
admet-613	63	18	log	log	NOUN
admet-613	63	19	of	of	ADP
admet-613	63	20	the	the	DET
admet-613	63	21	concentration	concentration	NOUN
admet-613	63	22	and	and	CCONJ
admet-613	63	23	time	time	NOUN
admet-613	63	24	curves	curve	NOUN
admet-613	63	25	.	.	PUNCT
admet-613	64	1	elimination	elimination	NOUN
admet-613	64	2	half	half	ADJ
admet-613	64	3	-	-	PUNCT
admet-613	64	4	life	life	NOUN
admet-613	64	5	(	(	PUNCT
admet-613	64	6	t1/2	t1/2	NOUN
admet-613	64	7	)	)	PUNCT
admet-613	64	8	was	be	AUX
admet-613	64	9	calculated	calculate	VERB
admet-613	64	10	as	as	ADP
admet-613	64	11	;	;	PUNCT
admet-613	64	12	t1/2	t1/2	PROPN
admet-613	64	13	=	=	NOUN
admet-613	64	14	0.693	0.693	NUM
admet-613	64	15	ke	ke	PROPN
admet-613	64	16	-1	-1	NOUN
admet-613	64	17	.	.	PUNCT
admet-613	65	1	results	result	NOUN
admet-613	65	2	and	and	CCONJ
admet-613	65	3	discussion	discussion	NOUN
admet-613	65	4	concentration	concentration	NOUN
admet-613	65	5	-	-	PUNCT
admet-613	65	6	time	time	NOUN
admet-613	65	7	curve	curve	NOUN
admet-613	65	8	of	of	ADP
admet-613	65	9	each	each	DET
admet-613	65	10	group	group	NOUN
admet-613	65	11	after	after	SCONJ
admet-613	65	12	amikacin	amikacin	PROPN
admet-613	65	13	samples	sample	NOUN
admet-613	65	14	were	be	AUX
admet-613	65	15	pooled	pool	VERB
admet-613	65	16	at	at	ADP
admet-613	65	17	the	the	DET
admet-613	65	18	various	various	ADJ
admet-613	65	19	predetermined	predetermine	VERB
admet-613	65	20	times	time	NOUN
admet-613	65	21	in	in	ADP
admet-613	65	22	the	the	DET
admet-613	65	23	sd	sd	NOUN
admet-613	65	24	rats	rat	NOUN
admet-613	65	25	is	be	AUX
admet-613	65	26	shown	show	VERB
admet-613	65	27	in	in	ADP
admet-613	65	28	figure	figure	NOUN
admet-613	65	29	1	1	NUM
admet-613	65	30	.	.	PUNCT
admet-613	65	31	estimates	estimate	NOUN
admet-613	65	32	of	of	ADP
admet-613	65	33	pharmacokinetic	pharmacokinetic	ADJ
admet-613	65	34	parameters	parameter	NOUN
admet-613	65	35	of	of	ADP
admet-613	65	36	amikacin	amikacin	PROPN
admet-613	65	37	in	in	ADP
admet-613	65	38	sd	sd	ADP
admet-613	65	39	rats	rat	NOUN
admet-613	65	40	(	(	PUNCT
admet-613	65	41	table	table	NOUN
admet-613	65	42	1	1	NUM
admet-613	65	43	)	)	PUNCT
admet-613	65	44	were	be	AUX
admet-613	65	45	obtained	obtain	VERB
admet-613	65	46	from	from	ADP
admet-613	65	47	concentration	concentration	NOUN
admet-613	65	48	-	-	PUNCT
admet-613	65	49	time	time	NOUN
admet-613	65	50	curves	curve	NOUN
admet-613	65	51	.	.	PUNCT
admet-613	66	1	elimination	elimination	NOUN
admet-613	66	2	(	(	PUNCT
admet-613	66	3	ke	ke	NOUN
admet-613	66	4	)	)	PUNCT
admet-613	66	5	of	of	ADP
admet-613	66	6	amikacin	amikacin	PROPN
admet-613	66	7	was	be	AUX
admet-613	66	8	faster	fast	ADV
admet-613	66	9	in	in	ADP
admet-613	66	10	sd	sd	ADP
admet-613	66	11	rats	rat	NOUN
admet-613	66	12	pre	pre	VERB
admet-613	66	13	-	-	VERB
admet-613	66	14	administered	administer	VERB
admet-613	66	15	with	with	ADP
admet-613	66	16	amponsah	amponsah	PROPN
admet-613	66	17	et	et	PROPN
admet-613	66	18	al	al	PROPN
admet-613	66	19	.	.	PROPN
admet-613	66	20	admet	admet	PROPN
admet-613	66	21	&	&	CCONJ
admet-613	66	22	dmpk	dmpk	PROPN
admet-613	66	23	6(4	6(4	PROPN
admet-613	66	24	)	)	PUNCT
admet-613	66	25	(	(	PUNCT
admet-613	66	26	2018	2018	NUM
admet-613	66	27	)	)	PUNCT
admet-613	66	28	279	279	NUM
admet-613	66	29	-	-	SYM
admet-613	66	30	283	283	NUM
admet-613	66	31	282	282	NUM
admet-613	66	32	betamethasone	betamethasone	NOUN
admet-613	66	33	compared	compare	VERB
admet-613	66	34	to	to	ADP
admet-613	66	35	sd	sd	NOUN
admet-613	66	36	rats	rat	NOUN
admet-613	66	37	pre	pre	VERB
admet-613	66	38	-	-	VERB
admet-613	66	39	administered	administer	VERB
admet-613	66	40	with	with	ADP
admet-613	66	41	normal	normal	ADJ
admet-613	66	42	saline	saline	NOUN
admet-613	66	43	,	,	PUNCT
admet-613	66	44	and	and	CCONJ
admet-613	66	45	this	this	PRON
admet-613	66	46	resulted	result	VERB
admet-613	66	47	in	in	ADP
admet-613	66	48	a	a	DET
admet-613	66	49	shorter	short	ADJ
admet-613	66	50	half	half	ADJ
admet-613	66	51	-	-	PUNCT
admet-613	66	52	life	life	NOUN
admet-613	66	53	for	for	ADP
admet-613	66	54	the	the	DET
admet-613	66	55	former	former	NOUN
admet-613	66	56	.	.	PUNCT
admet-613	67	1	the	the	DET
admet-613	67	2	maximum	maximum	ADJ
admet-613	67	3	amikacin	amikacin	PROPN
admet-613	67	4	concentration	concentration	NOUN
admet-613	67	5	(	(	PUNCT
admet-613	67	6	cmax	cmax	NOUN
admet-613	67	7	)	)	PUNCT
admet-613	67	8	for	for	ADP
admet-613	67	9	sd	sd	NOUN
admet-613	67	10	rats	rat	NOUN
admet-613	67	11	pre	pre	VERB
admet-613	67	12	-	-	VERB
admet-613	67	13	administered	administer	VERB
admet-613	67	14	with	with	ADP
admet-613	67	15	normal	normal	ADJ
admet-613	67	16	saline	saline	NOUN
admet-613	67	17	was	be	AUX
admet-613	67	18	about	about	ADV
admet-613	67	19	two	two	NUM
admet-613	67	20	-	-	PUNCT
admet-613	67	21	fold	fold	VERB
admet-613	67	22	higher	high	ADJ
admet-613	67	23	than	than	ADP
admet-613	67	24	sd	sd	ADP
admet-613	67	25	rats	rat	NOUN
admet-613	67	26	pre	pre	VERB
admet-613	67	27	-	-	VERB
admet-613	67	28	administered	administer	VERB
admet-613	67	29	with	with	ADP
admet-613	67	30	betamethasone	betamethasone	PROPN
admet-613	67	31	.	.	PUNCT
admet-613	68	1	total	total	ADJ
admet-613	68	2	drug	drug	NOUN
admet-613	68	3	exposure	exposure	NOUN
admet-613	68	4	from	from	ADP
admet-613	68	5	time	time	NOUN
admet-613	68	6	0	0	NUM
admet-613	68	7	to	to	PART
admet-613	68	8	8	8	NUM
admet-613	68	9	h	h	NOUN
admet-613	68	10	(	(	PUNCT
admet-613	68	11	auc0→8	auc0→8	NOUN
admet-613	68	12	)	)	PUNCT
admet-613	68	13	was	be	AUX
admet-613	68	14	also	also	ADV
admet-613	68	15	about	about	ADV
admet-613	68	16	four	four	NUM
admet-613	68	17	-	-	ADJ
admet-613	68	18	fold	fold	VERB
admet-613	68	19	greater	great	ADJ
admet-613	68	20	for	for	ADP
admet-613	68	21	the	the	DET
admet-613	68	22	sd	sd	NOUN
admet-613	68	23	rats	rat	NOUN
admet-613	68	24	pre	pre	VERB
admet-613	68	25	-	-	VERB
admet-613	68	26	administered	administer	VERB
admet-613	68	27	with	with	ADP
admet-613	68	28	normal	normal	ADJ
admet-613	68	29	saline	saline	NOUN
admet-613	68	30	.	.	PUNCT
admet-613	69	1	figure	figure	NOUN
admet-613	69	2	1	1	NUM
admet-613	69	3	.	.	PUNCT
admet-613	69	4	concentration	concentration	NOUN
admet-613	69	5	-	-	PUNCT
admet-613	69	6	time	time	NOUN
admet-613	69	7	curves	curve	NOUN
admet-613	69	8	of	of	ADP
admet-613	69	9	amikacin	amikacin	PROPN
admet-613	69	10	in	in	ADP
admet-613	69	11	rats	rat	NOUN
admet-613	69	12	after	after	ADP
admet-613	69	13	pre	pre	NOUN
admet-613	69	14	-	-	NOUN
admet-613	69	15	treatment	treatment	NOUN
admet-613	69	16	with	with	ADP
admet-613	69	17	normal	normal	ADJ
admet-613	69	18	saline	saline	NOUN
admet-613	69	19	(	(	PUNCT
admet-613	69	20	red	red	ADJ
admet-613	69	21	solid	solid	ADJ
admet-613	69	22	line	line	NOUN
admet-613	69	23	;	;	PUNCT
admet-613	69	24	filled	fill	VERB
admet-613	69	25	circles	circle	NOUN
admet-613	69	26	)	)	PUNCT
admet-613	69	27	and	and	CCONJ
admet-613	69	28	betamethasone	betamethasone	PROPN
admet-613	69	29	(	(	PUNCT
admet-613	69	30	gray	gray	VERB
admet-613	69	31	solid	solid	ADJ
admet-613	69	32	line	line	NOUN
admet-613	69	33	;	;	PUNCT
admet-613	69	34	filled	fill	VERB
admet-613	69	35	squares	square	NOUN
admet-613	69	36	)	)	PUNCT
admet-613	69	37	table	table	NOUN
admet-613	69	38	1	1	NUM
admet-613	69	39	.	.	PUNCT
admet-613	70	1	summary	summary	NOUN
admet-613	70	2	of	of	ADP
admet-613	70	3	amikacin	amikacin	PROPN
admet-613	70	4	pharmacokinetic	pharmacokinetic	ADJ
admet-613	70	5	parameters	parameter	NOUN
admet-613	70	6	among	among	ADP
admet-613	70	7	two	two	NUM
admet-613	70	8	groups	group	NOUN
admet-613	70	9	of	of	ADP
admet-613	70	10	rats	rat	NOUN
admet-613	70	11	pk	pk	NOUN
admet-613	70	12	parameter	parameter	NOUN
admet-613	70	13	(	(	PUNCT
admet-613	70	14	units	unit	NOUN
admet-613	70	15	)	)	PUNCT
admet-613	70	16	betamethasone	betamethasone	NOUN
admet-613	70	17	+	+	CCONJ
admet-613	70	18	amikacin	amikacin	PROPN
admet-613	70	19	normal	normal	ADJ
admet-613	70	20	saline	saline	NOUN
admet-613	70	21	+	+	CCONJ
admet-613	70	22	amikacin	amikacin	PROPN
admet-613	70	23	cmax	cmax	NOUN
admet-613	70	24	(	(	PUNCT
admet-613	70	25	μmol	μmol	NOUN
admet-613	70	26	l	l	NOUN
admet-613	70	27	-1	-1	PUNCT
admet-613	70	28	)	)	PUNCT
admet-613	71	1	16.60	16.60	NUM
admet-613	71	2	31.40	31.40	NUM
admet-613	71	3	auc0→8	auc0→8	PROPN
admet-613	71	4	(	(	PUNCT
admet-613	71	5	μmol	μmol	NOUN
admet-613	71	6	l-1	l-1	NOUN
admet-613	71	7	h-1	h-1	PROPN
admet-613	71	8	)	)	PUNCT
admet-613	71	9	26.80	26.80	NUM
admet-613	71	10	153.50	153.50	NUM
admet-613	71	11	ke	ke	NOUN
admet-613	71	12	(	(	PUNCT
admet-613	71	13	h	h	NOUN
admet-613	71	14	-1	-1	PUNCT
admet-613	71	15	)	)	PUNCT
admet-613	71	16	0.26	0.26	NUM
admet-613	71	17	0.18	0.18	NUM
admet-613	71	18	t1/2	t1/2	NOUN
admet-613	71	19	(	(	PUNCT
admet-613	71	20	h	h	NOUN
admet-613	71	21	)	)	PUNCT
admet-613	71	22	2.62	2.62	NUM
admet-613	71	23	3.96	3.96	NUM
admet-613	71	24	possible	possible	ADJ
admet-613	71	25	causes	cause	NOUN
admet-613	71	26	of	of	ADP
admet-613	71	27	resistance	resistance	NOUN
admet-613	71	28	to	to	ADP
admet-613	71	29	antibiotics	antibiotic	NOUN
admet-613	71	30	include	include	VERB
admet-613	71	31	amongst	amongst	ADP
admet-613	71	32	others	other	NOUN
admet-613	71	33	,	,	PUNCT
admet-613	71	34	drug	drug	NOUN
admet-613	71	35	-	-	PUNCT
admet-613	71	36	drug	drug	NOUN
admet-613	71	37	interactions	interaction	NOUN
admet-613	71	38	.	.	PUNCT
admet-613	72	1	drug	drug	NOUN
admet-613	72	2	interactions	interaction	NOUN
admet-613	72	3	leading	lead	VERB
admet-613	72	4	to	to	ADP
admet-613	72	5	low	low	ADJ
admet-613	72	6	serum	serum	NOUN
admet-613	72	7	levels	level	NOUN
admet-613	72	8	of	of	ADP
admet-613	72	9	antibiotics	antibiotic	NOUN
admet-613	72	10	can	can	AUX
admet-613	72	11	result	result	VERB
admet-613	72	12	in	in	ADP
admet-613	72	13	sub	sub	ADJ
admet-613	72	14	-	-	ADJ
admet-613	72	15	therapeutic	therapeutic	ADJ
admet-613	72	16	effect	effect	NOUN
admet-613	72	17	or	or	CCONJ
admet-613	72	18	emergence	emergence	NOUN
admet-613	72	19	of	of	ADP
admet-613	72	20	resistant	resistant	ADJ
admet-613	72	21	strains	strain	NOUN
admet-613	72	22	of	of	ADP
admet-613	72	23	microorganisms	microorganism	NOUN
admet-613	72	24	[	[	X
admet-613	72	25	11	11	NUM
admet-613	72	26	]	]	PUNCT
admet-613	72	27	.	.	PUNCT
admet-613	73	1	it	it	PRON
admet-613	73	2	is	be	AUX
admet-613	73	3	therefore	therefore	ADV
admet-613	73	4	imperative	imperative	ADJ
admet-613	73	5	that	that	SCONJ
admet-613	73	6	potential	potential	ADJ
admet-613	73	7	drug	drug	NOUN
admet-613	73	8	interactions	interaction	NOUN
admet-613	73	9	involving	involve	VERB
admet-613	73	10	antibiotics	antibiotic	NOUN
admet-613	73	11	are	be	AUX
admet-613	73	12	identified	identify	VERB
admet-613	73	13	.	.	PUNCT
admet-613	74	1	in	in	ADP
admet-613	74	2	this	this	DET
admet-613	74	3	study	study	NOUN
admet-613	74	4	,	,	PUNCT
admet-613	74	5	we	we	PRON
admet-613	74	6	investigated	investigate	VERB
admet-613	74	7	the	the	DET
admet-613	74	8	effect	effect	NOUN
admet-613	74	9	of	of	ADP
admet-613	74	10	pre	pre	NOUN
admet-613	74	11	-	-	NOUN
admet-613	74	12	treatment	treatment	NOUN
admet-613	74	13	of	of	ADP
admet-613	74	14	betamethasone	betamethasone	NOUN
admet-613	74	15	on	on	ADP
admet-613	74	16	the	the	DET
admet-613	74	17	disposition	disposition	NOUN
admet-613	74	18	of	of	ADP
admet-613	74	19	amikacin	amikacin	PROPN
admet-613	74	20	,	,	PUNCT
admet-613	74	21	after	after	ADP
admet-613	74	22	72	72	NUM
admet-613	74	23	h	h	NOUN
admet-613	74	24	,	,	PUNCT
admet-613	74	25	using	use	VERB
admet-613	74	26	an	an	DET
admet-613	74	27	animal	animal	NOUN
admet-613	74	28	model	model	NOUN
admet-613	74	29	.	.	PUNCT
admet-613	75	1	it	it	PRON
admet-613	75	2	is	be	AUX
admet-613	75	3	evident	evident	ADJ
admet-613	75	4	that	that	SCONJ
admet-613	75	5	amikacin	amikacin	PROPN
admet-613	75	6	was	be	AUX
admet-613	75	7	eliminated	eliminate	VERB
admet-613	75	8	at	at	ADP
admet-613	75	9	a	a	DET
admet-613	75	10	faster	fast	ADJ
admet-613	75	11	rate	rate	NOUN
admet-613	75	12	in	in	ADP
admet-613	75	13	the	the	DET
admet-613	75	14	betamethasone	betamethasone	NOUN
admet-613	75	15	pre	pre	VERB
admet-613	75	16	-	-	ADJ
admet-613	75	17	treated	treat	VERB
admet-613	75	18	group	group	NOUN
admet-613	75	19	compared	compare	VERB
admet-613	75	20	to	to	ADP
admet-613	75	21	the	the	DET
admet-613	75	22	normal	normal	ADJ
admet-613	75	23	saline	saline	NOUN
admet-613	75	24	pre	pre	ADJ
admet-613	75	25	-	-	ADJ
admet-613	75	26	treated	treat	VERB
admet-613	75	27	group	group	NOUN
admet-613	75	28	.	.	PUNCT
admet-613	76	1	this	this	PRON
admet-613	76	2	led	lead	VERB
admet-613	76	3	to	to	ADP
admet-613	76	4	a	a	DET
admet-613	76	5	shorter	short	ADJ
admet-613	76	6	half	half	ADJ
admet-613	76	7	-	-	PUNCT
admet-613	76	8	life	life	NOUN
admet-613	76	9	(	(	PUNCT
admet-613	76	10	2.62	2.62	NUM
admet-613	76	11	h	h	NOUN
admet-613	76	12	)	)	PUNCT
admet-613	76	13	in	in	ADP
admet-613	76	14	the	the	DET
admet-613	76	15	betamethasone	betamethasone	NOUN
admet-613	76	16	pre	pre	VERB
admet-613	76	17	-	-	ADJ
admet-613	76	18	treated	treat	VERB
admet-613	76	19	group	group	NOUN
admet-613	76	20	compared	compare	VERB
admet-613	76	21	to	to	ADP
admet-613	76	22	the	the	DET
admet-613	76	23	normal	normal	ADJ
admet-613	76	24	saline	saline	NOUN
admet-613	76	25	group	group	NOUN
admet-613	76	26	(	(	PUNCT
admet-613	76	27	3.96	3.96	NUM
admet-613	76	28	h	h	NOUN
admet-613	76	29	)	)	PUNCT
admet-613	76	30	.	.	PUNCT
admet-613	77	1	betamethasone	betamethasone	NOUN
admet-613	77	2	is	be	AUX
admet-613	77	3	known	know	VERB
admet-613	77	4	to	to	PART
admet-613	77	5	alter	alter	VERB
admet-613	77	6	kidney	kidney	NOUN
admet-613	77	7	function	function	NOUN
admet-613	77	8	by	by	ADP
admet-613	77	9	increasing	increase	VERB
admet-613	77	10	gfr	gfr	NOUN
admet-613	78	1	[	[	X
admet-613	78	2	2	2	NUM
admet-613	78	3	]	]	PUNCT
admet-613	78	4	,	,	PUNCT
admet-613	78	5	and	and	CCONJ
admet-613	78	6	this	this	PRON
admet-613	78	7	may	may	AUX
admet-613	78	8	have	have	AUX
admet-613	78	9	consequently	consequently	ADV
admet-613	78	10	led	lead	VERB
admet-613	78	11	to	to	ADP
admet-613	78	12	the	the	DET
admet-613	78	13	increase	increase	NOUN
admet-613	78	14	in	in	ADP
admet-613	78	15	renal	renal	ADJ
admet-613	78	16	elimination	elimination	NOUN
admet-613	78	17	of	of	ADP
admet-613	78	18	amikacin	amikacin	PROPN
admet-613	78	19	in	in	ADP
admet-613	78	20	the	the	DET
admet-613	78	21	betamethasone	betamethasone	NOUN
admet-613	78	22	pre	pre	VERB
admet-613	78	23	-	-	ADJ
admet-613	78	24	treated	treat	VERB
admet-613	78	25	group	group	NOUN
admet-613	78	26	of	of	ADP
admet-613	78	27	this	this	DET
admet-613	78	28	study	study	NOUN
admet-613	78	29	.	.	PUNCT
admet-613	79	1	the	the	DET
admet-613	79	2	outcome	outcome	NOUN
admet-613	79	3	of	of	ADP
admet-613	79	4	this	this	DET
admet-613	79	5	work	work	NOUN
admet-613	79	6	suggests	suggest	VERB
admet-613	79	7	that	that	SCONJ
admet-613	79	8	pre	pre	NOUN
admet-613	79	9	-	-	NOUN
admet-613	79	10	treatment	treatment	NOUN
admet-613	79	11	with	with	ADP
admet-613	79	12	betamethasone	betamethasone	NOUN
admet-613	79	13	could	could	AUX
admet-613	79	14	increase	increase	VERB
admet-613	79	15	renal	renal	ADJ
admet-613	79	16	elimination	elimination	NOUN
admet-613	79	17	of	of	ADP
admet-613	79	18	amikacin	amikacin	PROPN
admet-613	79	19	,	,	PUNCT
admet-613	79	20	possibly	possibly	ADV
admet-613	79	21	through	through	ADP
admet-613	79	22	increasing	increase	VERB
admet-613	79	23	gfr	gfr	NOUN
admet-613	79	24	72	72	NUM
admet-613	79	25	h	h	NOUN
admet-613	79	26	after	after	ADP
admet-613	79	27	daily	daily	ADJ
admet-613	79	28	amikacin	amikacin	PROPN
admet-613	79	29	administration	administration	NOUN
admet-613	79	30	.	.	PUNCT
admet-613	80	1	if	if	SCONJ
admet-613	80	2	indeed	indeed	ADV
admet-613	80	3	this	this	DET
admet-613	80	4	effect	effect	NOUN
admet-613	80	5	observed	observe	VERB
admet-613	80	6	in	in	ADP
admet-613	80	7	the	the	DET
admet-613	80	8	current	current	ADJ
admet-613	80	9	study	study	NOUN
admet-613	80	10	occurs	occur	VERB
admet-613	80	11	in	in	ADP
admet-613	80	12	newborns	newborn	NOUN
admet-613	80	13	,	,	PUNCT
admet-613	80	14	then	then	ADV
admet-613	80	15	there	there	PRON
admet-613	80	16	may	may	AUX
admet-613	80	17	be	be	AUX
admet-613	80	18	a	a	DET
admet-613	80	19	need	need	NOUN
admet-613	80	20	for	for	ADP
admet-613	80	21	dose	dose	NOUN
admet-613	80	22	modification	modification	NOUN
admet-613	80	23	in	in	ADP
admet-613	80	24	those	those	PRON
admet-613	80	25	who	who	PRON
admet-613	80	26	receive	receive	VERB
admet-613	80	27	prenatal	prenatal	ADJ
admet-613	80	28	corticosteroids	corticosteroid	NOUN
admet-613	80	29	.	.	PUNCT
admet-613	81	1	admet	admet	PROPN
admet-613	81	2	&	&	CCONJ
admet-613	81	3	dmpk	dmpk	PROPN
admet-613	81	4	6(4	6(4	PROPN
admet-613	81	5	)	)	PUNCT
admet-613	81	6	(	(	PUNCT
admet-613	81	7	2018	2018	NUM
admet-613	81	8	)	)	PUNCT
admet-613	81	9	279	279	NUM
admet-613	81	10	-	-	SYM
admet-613	81	11	283	283	NUM
admet-613	81	12	betamethasone	betamethasone	NOUN
admet-613	81	13	affects	affect	VERB
admet-613	81	14	the	the	DET
admet-613	81	15	disposition	disposition	NOUN
admet-613	81	16	of	of	ADP
admet-613	81	17	amikacin	amikacin	PROPN
admet-613	81	18	doi	doi	NOUN
admet-613	81	19	:	:	PUNCT
admet-613	81	20	10.5599	10.5599	NUM
admet-613	81	21	/	/	SYM
admet-613	81	22	admet.613	admet.613	PROPN
admet-613	81	23	283	283	NUM
admet-613	81	24	conclusions	conclusion	NOUN
admet-613	81	25	the	the	DET
admet-613	81	26	current	current	ADJ
admet-613	81	27	study	study	NOUN
admet-613	81	28	showed	show	VERB
admet-613	81	29	that	that	SCONJ
admet-613	81	30	betamethasone	betamethasone	PROPN
admet-613	81	31	altered	alter	VERB
admet-613	81	32	the	the	DET
admet-613	81	33	pharmacokinetic	pharmacokinetic	ADJ
admet-613	81	34	parameters	parameter	NOUN
admet-613	81	35	of	of	ADP
admet-613	81	36	amikacin	amikacin	PROPN
admet-613	81	37	in	in	ADP
admet-613	81	38	sprague	sprague	NOUN
admet-613	81	39	-	-	PUNCT
admet-613	81	40	dawley	dawley	NOUN
admet-613	81	41	rats	rat	NOUN
admet-613	81	42	72	72	NUM
admet-613	81	43	h	h	NOUN
admet-613	81	44	after	after	ADP
admet-613	81	45	daily	daily	ADJ
admet-613	81	46	amikacin	amikacin	PROPN
admet-613	81	47	administration	administration	NOUN
admet-613	81	48	.	.	PUNCT
admet-613	82	1	although	although	SCONJ
admet-613	82	2	this	this	DET
admet-613	82	3	study	study	NOUN
admet-613	82	4	was	be	AUX
admet-613	82	5	conducted	conduct	VERB
admet-613	82	6	in	in	ADP
admet-613	82	7	an	an	DET
admet-613	82	8	animal	animal	NOUN
admet-613	82	9	model	model	NOUN
admet-613	82	10	,	,	PUNCT
admet-613	82	11	this	this	DET
admet-613	82	12	finding	finding	NOUN
admet-613	82	13	is	be	AUX
admet-613	82	14	noteworthy	noteworthy	ADJ
admet-613	82	15	,	,	PUNCT
admet-613	82	16	as	as	SCONJ
admet-613	82	17	this	this	PRON
admet-613	82	18	may	may	AUX
admet-613	82	19	serve	serve	VERB
admet-613	82	20	as	as	ADP
admet-613	82	21	a	a	DET
admet-613	82	22	basis	basis	NOUN
admet-613	82	23	for	for	ADP
admet-613	82	24	future	future	ADJ
admet-613	82	25	studies	study	NOUN
admet-613	82	26	in	in	ADP
admet-613	82	27	humans	human	NOUN
admet-613	82	28	where	where	SCONJ
admet-613	82	29	blood	blood	NOUN
admet-613	82	30	samples	sample	NOUN
admet-613	82	31	for	for	ADP
admet-613	82	32	pharmacokinetic	pharmacokinetic	ADJ
admet-613	82	33	evaluation	evaluation	NOUN
admet-613	82	34	of	of	ADP
admet-613	82	35	amikacin	amikacin	PROPN
admet-613	82	36	are	be	AUX
admet-613	82	37	taken	take	VERB
admet-613	82	38	after	after	ADP
admet-613	82	39	day	day	NOUN
admet-613	82	40	3	3	NUM
admet-613	82	41	of	of	ADP
admet-613	82	42	the	the	DET
admet-613	82	43	life	life	NOUN
admet-613	82	44	of	of	ADP
admet-613	82	45	preterm	preterm	ADJ
admet-613	82	46	newborns	newborn	NOUN
admet-613	82	47	.	.	PUNCT
admet-613	83	1	acknowledgements	acknowledgement	NOUN
admet-613	83	2	the	the	DET
admet-613	83	3	authors	author	NOUN
admet-613	83	4	are	be	AUX
admet-613	83	5	grateful	grateful	ADJ
admet-613	83	6	to	to	ADP
admet-613	83	7	perseus	perseus	PROPN
admet-613	83	8	nana	nana	PROPN
admet-613	83	9	asare	asare	PROPN
admet-613	83	10	and	and	CCONJ
admet-613	83	11	kwabena	kwabena	PROPN
admet-613	83	12	antwi	antwi	PROPN
admet-613	83	13	,	,	PUNCT
admet-613	83	14	who	who	PRON
admet-613	83	15	helped	help	VERB
admet-613	83	16	with	with	ADP
admet-613	83	17	animal	animal	NOUN
admet-613	83	18	handling	handling	NOUN
admet-613	83	19	.	.	PUNCT
admet-613	84	1	thanks	thank	NOUN
admet-613	84	2	also	also	ADV
admet-613	84	3	go	go	VERB
admet-613	84	4	to	to	ADP
admet-613	84	5	the	the	DET
admet-613	84	6	technical	technical	ADJ
admet-613	84	7	staff	staff	NOUN
admet-613	84	8	of	of	ADP
admet-613	84	9	the	the	DET
admet-613	84	10	department	department	NOUN
admet-613	84	11	of	of	ADP
admet-613	84	12	pharmacology	pharmacology	NOUN
admet-613	84	13	and	and	CCONJ
admet-613	84	14	toxicology	toxicology	NOUN
admet-613	84	15	,	,	PUNCT
admet-613	84	16	and	and	CCONJ
admet-613	84	17	department	department	NOUN
admet-613	84	18	of	of	ADP
admet-613	84	19	pharmaceutical	pharmaceutical	ADJ
admet-613	84	20	chemistry	chemistry	NOUN
admet-613	84	21	,	,	PUNCT
admet-613	84	22	school	school	NOUN
admet-613	84	23	of	of	ADP
admet-613	84	24	pharmacy	pharmacy	NOUN
admet-613	84	25	,	,	PUNCT
admet-613	84	26	university	university	NOUN
admet-613	84	27	of	of	ADP
admet-613	84	28	ghana	ghana	PROPN
admet-613	84	29	.	.	PUNCT
admet-613	85	1	references	reference	NOUN
admet-613	85	2	[	[	X
admet-613	85	3	1	1	NUM
admet-613	85	4	]	]	PUNCT
admet-613	85	5	care	care	NOUN
admet-613	85	6	of	of	ADP
admet-613	85	7	the	the	DET
admet-613	85	8	preterm	preterm	NOUN
admet-613	85	9	and	and	CCONJ
admet-613	85	10	low	low	ADJ
admet-613	85	11	-	-	PUNCT
admet-613	85	12	birth	birth	NOUN
admet-613	85	13	-	-	PUNCT
admet-613	85	14	weight	weight	NOUN
admet-613	85	15	newborn	newborn	NOUN
admet-613	85	16	.	.	PUNCT
admet-613	86	1	world	world	PROPN
admet-613	86	2	health	health	PROPN
admet-613	86	3	organization	organization	PROPN
admet-613	86	4	,	,	PUNCT
admet-613	86	5	geneva	geneva	PROPN
admet-613	86	6	,	,	PUNCT
admet-613	86	7	switzerland	switzerland	PROPN
admet-613	86	8	.	.	PUNCT
admet-613	87	1	[	[	X
admet-613	87	2	2	2	X
admet-613	87	3	]	]	X
admet-613	87	4	j.n	j.n	PROPN
admet-613	87	5	.	.	PROPN
admet-613	87	6	van	van	PROPN
admet-613	87	7	den	den	PROPN
admet-613	87	8	anker	anker	PROPN
admet-613	87	9	,	,	PUNCT
admet-613	87	10	w.c	w.c	PROPN
admet-613	87	11	.	.	PROPN
admet-613	87	12	hop	hop	PROPN
admet-613	87	13	,	,	PUNCT
admet-613	87	14	r.	r.	PROPN
admet-613	87	15	de	de	PROPN
admet-613	87	16	groot	groot	PROPN
admet-613	87	17	,	,	PUNCT
admet-613	87	18	b.j	b.j	PROPN
admet-613	87	19	.	.	PROPN
admet-613	87	20	van	van	PROPN
admet-613	87	21	der	der	PROPN
admet-613	87	22	heijden	heijden	PROPN
admet-613	87	23	,	,	PUNCT
admet-613	87	24	h.m	h.m	PROPN
admet-613	87	25	.	.	PROPN
admet-613	87	26	broerse	broerse	PROPN
admet-613	87	27	,	,	PUNCT
admet-613	87	28	j.	j.	PROPN
admet-613	87	29	lindemans	lindemans	PROPN
admet-613	87	30	,	,	PUNCT
admet-613	87	31	p.j	p.j	PROPN
admet-613	87	32	.	.	PROPN
admet-613	87	33	sauer	sauer	PROPN
admet-613	87	34	.	.	PUNCT
admet-613	88	1	effects	effect	NOUN
admet-613	88	2	of	of	ADP
admet-613	88	3	prenatal	prenatal	ADJ
admet-613	88	4	exposure	exposure	NOUN
admet-613	88	5	to	to	ADP
admet-613	88	6	betamethasone	betamethasone	NOUN
admet-613	88	7	and	and	CCONJ
admet-613	88	8	indomethacin	indomethacin	VERB
admet-613	88	9	on	on	ADP
admet-613	88	10	the	the	DET
admet-613	88	11	glomerular	glomerular	ADJ
admet-613	88	12	filtration	filtration	NOUN
admet-613	88	13	rate	rate	NOUN
admet-613	88	14	in	in	ADP
admet-613	88	15	the	the	DET
admet-613	88	16	preterm	preterm	NOUN
admet-613	88	17	infant	infant	NOUN
admet-613	88	18	.	.	PUNCT
admet-613	89	1	pediatr	pediatr	ADJ
admet-613	89	2	res	re	NOUN
admet-613	89	3	36	36	NUM
admet-613	89	4	(	(	PUNCT
admet-613	89	5	1994	1994	NUM
admet-613	89	6	)	)	PUNCT
admet-613	89	7	578	578	NUM
admet-613	89	8	-	-	SYM
admet-613	89	9	581	581	NUM
admet-613	89	10	.	.	PUNCT
admet-613	90	1	[	[	X
admet-613	90	2	3	3	X
admet-613	90	3	]	]	X
admet-613	90	4	j.l	j.l	PROPN
admet-613	90	5	.	.	PROPN
admet-613	90	6	wynn	wynn	PROPN
admet-613	90	7	,	,	PUNCT
admet-613	90	8	j.	j.	PROPN
admet-613	90	9	neu	neu	PROPN
admet-613	90	10	,	,	PUNCT
admet-613	90	11	l.l	l.l	PROPN
admet-613	90	12	.	.	PROPN
admet-613	90	13	moldawer	moldawer	PROPN
admet-613	90	14	,	,	PUNCT
admet-613	90	15	o.	o.	PROPN
admet-613	90	16	levy	levy	NOUN
admet-613	90	17	.	.	PUNCT
admet-613	91	1	potential	potential	NOUN
admet-613	91	2	of	of	ADP
admet-613	91	3	immunomodulatory	immunomodulatory	ADJ
admet-613	91	4	agents	agent	NOUN
admet-613	91	5	for	for	ADP
admet-613	91	6	prevention	prevention	NOUN
admet-613	91	7	and	and	CCONJ
admet-613	91	8	treatment	treatment	NOUN
admet-613	91	9	of	of	ADP
admet-613	91	10	neonatal	neonatal	ADJ
admet-613	91	11	sepsis	sepsis	NOUN
admet-613	91	12	.	.	PUNCT
admet-613	92	1	j	j	PROPN
admet-613	92	2	perinatol	perinatol	VERB
admet-613	92	3	29	29	NUM
admet-613	92	4	(	(	PUNCT
admet-613	92	5	2009	2009	NUM
admet-613	92	6	)	)	PUNCT
admet-613	92	7	79	79	NUM
admet-613	92	8	-	-	SYM
admet-613	92	9	88	88	NUM
admet-613	92	10	.	.	PUNCT
admet-613	93	1	[	[	X
admet-613	93	2	4	4	NUM
admet-613	93	3	]	]	PUNCT
admet-613	93	4	a.	a.	NOUN
admet-613	93	5	siddiqi	siddiqi	PROPN
admet-613	93	6	,	,	PUNCT
admet-613	93	7	d.a	d.a	PROPN
admet-613	93	8	.	.	PROPN
admet-613	93	9	khan	khan	PROPN
admet-613	93	10	,	,	PUNCT
admet-613	93	11	f.a	f.a	PROPN
admet-613	93	12	.	.	PROPN
admet-613	93	13	khan	khan	PROPN
admet-613	93	14	,	,	PUNCT
admet-613	93	15	a.	a.	PROPN
admet-613	93	16	razzaq	razzaq	PROPN
admet-613	93	17	.	.	PUNCT
admet-613	94	1	therapeutic	therapeutic	ADJ
admet-613	94	2	drug	drug	NOUN
admet-613	94	3	monitoring	monitoring	NOUN
admet-613	94	4	of	of	ADP
admet-613	94	5	amikacin	amikacin	PROPN
admet-613	94	6	in	in	ADP
admet-613	94	7	preterm	preterm	NOUN
admet-613	94	8	and	and	CCONJ
admet-613	94	9	term	term	NOUN
admet-613	94	10	infants	infant	NOUN
admet-613	94	11	.	.	PUNCT
admet-613	95	1	singapore	singapore	PROPN
admet-613	95	2	med	med	PROPN
admet-613	95	3	j	j	PROPN
admet-613	95	4	50	50	NUM
admet-613	95	5	(	(	PUNCT
admet-613	95	6	2009	2009	NUM
admet-613	95	7	)	)	PUNCT
admet-613	95	8	486	486	NUM
admet-613	95	9	-	-	SYM
admet-613	95	10	489	489	NUM
admet-613	95	11	.	.	PUNCT
admet-613	96	1	[	[	X
admet-613	96	2	5	5	X
admet-613	96	3	]	]	PUNCT
admet-613	96	4	k.	k.	PROPN
admet-613	96	5	bruce	bruce	PROPN
admet-613	96	6	,	,	PUNCT
admet-613	96	7	r.w	r.w	PROPN
admet-613	96	8	.	.	PROPN
admet-613	96	9	hicks	hicks	PROPN
admet-613	96	10	.	.	PUNCT
admet-613	97	1	perioperative	perioperative	ADJ
admet-613	97	2	pharmacology	pharmacology	NOUN
admet-613	97	3	:	:	PUNCT
admet-613	97	4	a	a	DET
admet-613	97	5	focus	focus	NOUN
admet-613	97	6	on	on	ADP
admet-613	97	7	aminoglycosides	aminoglycoside	NOUN
admet-613	97	8	.	.	PUNCT
admet-613	98	1	aorn	aorn	VERB
admet-613	98	2	j	j	PROPN
admet-613	98	3	93	93	NUM
admet-613	98	4	(	(	PUNCT
admet-613	98	5	2011	2011	NUM
admet-613	98	6	)	)	PUNCT
admet-613	98	7	464	464	NUM
admet-613	98	8	-	-	SYM
admet-613	98	9	468	468	NUM
admet-613	98	10	;	;	PUNCT
admet-613	98	11	quiz	quiz	NOUN
admet-613	98	12	469	469	NUM
admet-613	98	13	-	-	NUM
admet-613	98	14	471	471	NUM
admet-613	98	15	.	.	PUNCT
admet-613	99	1	[	[	X
admet-613	99	2	6	6	NUM
admet-613	99	3	]	]	PUNCT
admet-613	99	4	k.	k.	PROPN
admet-613	99	5	allegaert	allegaert	PROPN
admet-613	99	6	,	,	PUNCT
admet-613	99	7	v.	v.	ADP
admet-613	99	8	cossey	cossey	NOUN
admet-613	99	9	,	,	PUNCT
admet-613	99	10	m.	m.	NOUN
admet-613	99	11	rayyan	rayyan	PROPN
admet-613	99	12	,	,	PUNCT
admet-613	99	13	c.	c.	PROPN
admet-613	99	14	vanhole	vanhole	PROPN
admet-613	99	15	,	,	PUNCT
admet-613	99	16	h.	h.	PROPN
admet-613	99	17	devlieger	devlieger	PROPN
admet-613	99	18	.	.	PUNCT
admet-613	100	1	administration	administration	PROPN
admet-613	100	2	of	of	ADP
admet-613	100	3	betamethasone	betamethasone	PROPN
admet-613	100	4	before	before	ADP
admet-613	100	5	birth	birth	NOUN
admet-613	100	6	has	have	VERB
admet-613	100	7	no	no	DET
admet-613	100	8	effect	effect	NOUN
admet-613	100	9	on	on	ADP
admet-613	100	10	the	the	DET
admet-613	100	11	amikacin	amikacin	PROPN
admet-613	100	12	pharmacokinetics	pharmacokinetic	NOUN
admet-613	100	13	in	in	ADP
admet-613	100	14	preterm	preterm	ADJ
admet-613	100	15	infants	infant	NOUN
admet-613	100	16	at	at	ADP
admet-613	100	17	birth	birth	NOUN
admet-613	100	18	.	.	PUNCT
admet-613	101	1	paediatric	paediatric	ADJ
admet-613	101	2	and	and	CCONJ
admet-613	101	3	perinatal	perinatal	ADJ
admet-613	101	4	drug	drug	NOUN
admet-613	101	5	therapy	therapy	NOUN
admet-613	101	6	6	6	NUM
admet-613	101	7	(	(	PUNCT
admet-613	101	8	2005	2005	NUM
admet-613	101	9	)	)	PUNCT
admet-613	101	10	149	149	NUM
admet-613	101	11	-	-	SYM
admet-613	101	12	154	154	NUM
admet-613	101	13	.	.	PUNCT
admet-613	102	1	[	[	X
admet-613	102	2	7	7	X
admet-613	102	3	]	]	X
admet-613	102	4	memorandum	memorandum	NOUN
admet-613	102	5	of	of	ADP
admet-613	102	6	understanding	understanding	NOUN
admet-613	102	7	between	between	ADP
admet-613	102	8	the	the	DET
admet-613	102	9	office	office	NOUN
admet-613	102	10	of	of	ADP
admet-613	102	11	laboratory	laboratory	NOUN
admet-613	102	12	animal	animal	NOUN
admet-613	102	13	welfare	welfare	NOUN
admet-613	102	14	natioanal	natioanal	ADJ
admet-613	102	15	institutes	institutes	PROPN
admet-613	102	16	of	of	ADP
admet-613	102	17	health	health	PROPN
admet-613	102	18	u.s	u.s	PROPN
admet-613	102	19	.	.	PROPN
admet-613	102	20	department	department	PROPN
admet-613	102	21	of	of	ADP
admet-613	102	22	health	health	PROPN
admet-613	102	23	and	and	CCONJ
admet-613	102	24	human	human	ADJ
admet-613	102	25	services	service	NOUN
admet-613	102	26	and	and	CCONJ
admet-613	102	27	the	the	DET
admet-613	102	28	office	office	NOUN
admet-613	102	29	of	of	ADP
admet-613	102	30	research	research	NOUN
admet-613	102	31	oversight	oversight	NOUN
admet-613	102	32	and	and	CCONJ
admet-613	102	33	the	the	DET
admet-613	102	34	office	office	NOUN
admet-613	102	35	of	of	ADP
admet-613	102	36	research	research	NOUN
admet-613	102	37	and	and	CCONJ
admet-613	102	38	development	development	NOUN
admet-613	102	39	veterans	veterans	PROPN
admet-613	102	40	health	health	PROPN
admet-613	102	41	administration	administration	PROPN
admet-613	102	42	u.s	u.s	PROPN
admet-613	102	43	.	.	PROPN
admet-613	102	44	department	department	PROPN
admet-613	102	45	of	of	ADP
admet-613	102	46	veterans	veterans	PROPN
admet-613	102	47	affairs	affair	NOUN
admet-613	102	48	concerning	concern	VERB
admet-613	102	49	laboratory	laboratory	NOUN
admet-613	102	50	animal	animal	NOUN
admet-613	102	51	welfare	welfare	NOUN
admet-613	102	52	.	.	PUNCT
admet-613	103	1	national	national	ADJ
admet-613	103	2	institutes	institutes	PROPN
admet-613	103	3	of	of	ADP
admet-613	103	4	health	health	NOUN
admet-613	103	5	,	,	PUNCT
admet-613	103	6	2007	2007	NUM
admet-613	103	7	.	.	PUNCT
admet-613	104	1	[	[	X
admet-613	104	2	8	8	NUM
admet-613	104	3	]	]	X
admet-613	104	4	h.j	h.j	PROPN
admet-613	104	5	.	.	PROPN
admet-613	104	6	olguín	olguín	PROPN
admet-613	104	7	,	,	PUNCT
admet-613	104	8	m.c	m.c	PROPN
admet-613	104	9	.	.	PROPN
admet-613	104	10	portugal	portugal	PROPN
admet-613	104	11	,	,	PUNCT
admet-613	104	12	j.f	j.f	PROPN
admet-613	104	13	.	.	PROPN
admet-613	104	14	pérez	pérez	PROPN
admet-613	104	15	,	,	PUNCT
admet-613	104	16	a.c	a.c	PROPN
admet-613	104	17	.	.	PROPN
admet-613	104	18	vieyra	vieyra	PROPN
admet-613	104	19	,	,	PUNCT
admet-613	104	20	c.f	c.f	PROPN
admet-613	104	21	.	.	PROPN
admet-613	104	22	pérez	pérez	PROPN
admet-613	104	23	,	,	PUNCT
admet-613	104	24	a.a	a.a	PROPN
admet-613	104	25	.	.	PROPN
admet-613	104	26	rodríguez	rodríguez	PROPN
admet-613	104	27	.	.	PUNCT
admet-613	105	1	effect	effect	NOUN
admet-613	105	2	of	of	ADP
admet-613	105	3	mannitol	mannitol	NOUN
admet-613	105	4	on	on	ADP
admet-613	105	5	the	the	DET
admet-613	105	6	pharmacokinetics	pharmacokinetic	NOUN
admet-613	105	7	of	of	ADP
admet-613	105	8	amikacin	amikacin	PROPN
admet-613	105	9	in	in	ADP
admet-613	105	10	wistar	wistar	PROPN
admet-613	105	11	rats	rat	NOUN
admet-613	105	12	.	.	PUNCT
admet-613	106	1	brazilian	brazilian	ADJ
admet-613	106	2	archives	archive	NOUN
admet-613	106	3	of	of	ADP
admet-613	106	4	biology	biology	NOUN
admet-613	106	5	and	and	CCONJ
admet-613	106	6	technology	technology	NOUN
admet-613	106	7	52	52	NUM
admet-613	106	8	(	(	PUNCT
admet-613	106	9	2009	2009	NUM
admet-613	106	10	)	)	PUNCT
admet-613	106	11	835	835	NUM
admet-613	106	12	-	-	SYM
admet-613	106	13	839	839	NUM
admet-613	106	14	.	.	PUNCT
admet-613	107	1	[	[	X
admet-613	107	2	9	9	NUM
admet-613	107	3	]	]	X
admet-613	107	4	l.e	l.e	PROPN
admet-613	107	5	.	.	PROPN
admet-613	107	6	riad	riad	PROPN
admet-613	107	7	,	,	PUNCT
admet-613	107	8	k.k	k.k	PROPN
admet-613	107	9	.	.	PROPN
admet-613	107	10	chan	chan	PROPN
admet-613	107	11	,	,	PUNCT
admet-613	107	12	r.j	r.j	PROPN
admet-613	107	13	.	.	PROPN
admet-613	107	14	sawchuk	sawchuk	PROPN
admet-613	107	15	.	.	PUNCT
admet-613	108	1	determination	determination	NOUN
admet-613	108	2	of	of	ADP
admet-613	108	3	the	the	DET
admet-613	108	4	relative	relative	ADJ
admet-613	108	5	formation	formation	NOUN
admet-613	108	6	and	and	CCONJ
admet-613	108	7	elimination	elimination	NOUN
admet-613	108	8	clearance	clearance	NOUN
admet-613	108	9	of	of	ADP
admet-613	108	10	two	two	NUM
admet-613	108	11	major	major	ADJ
admet-613	108	12	carbamazepine	carbamazepine	NOUN
admet-613	108	13	metabolites	metabolite	NOUN
admet-613	108	14	in	in	ADP
admet-613	108	15	humans	human	NOUN
admet-613	108	16	:	:	PUNCT
admet-613	108	17	a	a	DET
admet-613	108	18	comparison	comparison	NOUN
admet-613	108	19	between	between	ADP
admet-613	108	20	traditional	traditional	ADJ
admet-613	108	21	and	and	CCONJ
admet-613	108	22	pooled	pool	VERB
admet-613	108	23	sample	sample	NOUN
admet-613	108	24	analysis	analysis	NOUN
admet-613	108	25	.	.	PUNCT
admet-613	109	1	pharmaceutical	pharmaceutical	ADJ
admet-613	109	2	research	research	NOUN
admet-613	109	3	8	8	NUM
admet-613	109	4	(	(	PUNCT
admet-613	109	5	1991	1991	NUM
admet-613	109	6	)	)	PUNCT
admet-613	109	7	541	541	NUM
admet-613	109	8	-	-	SYM
admet-613	109	9	543	543	NUM
admet-613	109	10	.	.	PUNCT
admet-613	110	1	[	[	X
admet-613	110	2	10	10	NUM
admet-613	110	3	]	]	X
admet-613	110	4	i.	i.	PROPN
admet-613	110	5	hemmila	hemmila	PROPN
admet-613	110	6	.	.	PUNCT
admet-613	111	1	fluoroimmunoassays	fluoroimmunoassay	NOUN
admet-613	111	2	and	and	CCONJ
admet-613	111	3	immunofluorometric	immunofluorometric	ADJ
admet-613	111	4	assays	assay	NOUN
admet-613	111	5	.	.	PUNCT
admet-613	112	1	clin	clin	PROPN
admet-613	112	2	chem	chem	NOUN
admet-613	112	3	31	31	NUM
admet-613	112	4	(	(	PUNCT
admet-613	112	5	1985	1985	NUM
admet-613	112	6	)	)	PUNCT
admet-613	112	7	359	359	NUM
admet-613	112	8	-	-	SYM
admet-613	112	9	370	370	NUM
admet-613	112	10	.	.	PUNCT
admet-613	113	1	[	[	X
admet-613	113	2	11	11	NUM
admet-613	113	3	]	]	PUNCT
admet-613	113	4	j.	j.	PROPN
admet-613	113	5	van	van	PROPN
admet-613	113	6	den	den	PROPN
admet-613	113	7	anker	anker	NOUN
admet-613	113	8	.	.	PUNCT
admet-613	114	1	pharmacokinetics	pharmacokinetic	NOUN
admet-613	114	2	and	and	CCONJ
admet-613	114	3	renal	renal	ADJ
admet-613	114	4	function	function	NOUN
admet-613	114	5	in	in	ADP
admet-613	114	6	preterm	preterm	ADJ
admet-613	114	7	infants	infant	NOUN
admet-613	114	8	.	.	PUNCT
admet-613	115	1	acta	acta	PROPN
admet-613	115	2	paediatrica	paediatrica	PROPN
admet-613	115	3	85	85	NUM
admet-613	115	4	(	(	PUNCT
admet-613	115	5	1996	1996	NUM
admet-613	115	6	)	)	PUNCT
admet-613	115	7	1393	1393	NUM
admet-613	115	8	-	-	SYM
admet-613	115	9	1399	1399	NUM
admet-613	115	10	.	.	PUNCT
admet-613	116	1	©	©	PROPN
admet-613	116	2	2018	2018	NUM
admet-613	116	3	by	by	ADP
admet-613	116	4	the	the	DET
admet-613	116	5	authors	author	NOUN
admet-613	116	6	;	;	PUNCT
admet-613	117	1	licensee	licensee	PROPN
admet-613	117	2	iapc	iapc	PROPN
admet-613	117	3	,	,	PUNCT
admet-613	117	4	zagreb	zagreb	PROPN
admet-613	117	5	,	,	PUNCT
admet-613	117	6	croatia	croatia	PROPN
admet-613	117	7	.	.	PUNCT
admet-613	118	1	this	this	DET
admet-613	118	2	article	article	NOUN
admet-613	118	3	is	be	AUX
admet-613	118	4	an	an	DET
admet-613	118	5	open	open	ADJ
admet-613	118	6	-	-	PUNCT
admet-613	118	7	access	access	NOUN
admet-613	118	8	article	article	NOUN
admet-613	118	9	distributed	distribute	VERB
admet-613	118	10	under	under	ADP
admet-613	118	11	the	the	DET
admet-613	118	12	terms	term	NOUN
admet-613	118	13	and	and	CCONJ
admet-613	118	14	conditions	condition	NOUN
admet-613	118	15	of	of	ADP
admet-613	118	16	the	the	DET
admet-613	118	17	creative	creative	ADJ
admet-613	118	18	commons	common	NOUN
admet-613	118	19	attribution	attribution	NOUN
admet-613	118	20	license	license	NOUN
admet-613	118	21	(	(	PUNCT
admet-613	118	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-613	118	23	)	)	PUNCT
admet-613	118	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN