id	sid	tid	token	lemma	pos
admet-621	1	1	effects	effect	NOUN
admet-621	1	2	of	of	ADP
admet-621	1	3	amount	amount	NOUN
admet-621	1	4	of	of	ADP
admet-621	1	5	excess	excess	NOUN
admet-621	1	6	solid	solid	ADJ
admet-621	1	7	,	,	PUNCT
admet-621	1	8	the	the	DET
admet-621	1	9	type	type	NOUN
admet-621	1	10	of	of	ADP
admet-621	1	11	stirring	stirring	NOUN
admet-621	1	12	and	and	CCONJ
admet-621	1	13	sedimentation	sedimentation	NOUN
admet-621	1	14	time	time	NOUN
admet-621	1	15	on	on	ADP
admet-621	1	16	solubility	solubility	NOUN
admet-621	1	17	of	of	ADP
admet-621	1	18	sodium	sodium	NOUN
admet-621	1	19	phenytoin	phenytoin	NOUN
admet-621	1	20	and	and	CCONJ
admet-621	1	21	lamotrigine	lamotrigine	ADJ
admet-621	1	22	doi	doi	NOUN
admet-621	1	23	:	:	PUNCT
admet-621	1	24	10.5599	10.5599	NUM
admet-621	1	25	/	/	SYM
admet-621	1	26	admet.621	admet.621	PROPN
admet-621	1	27	269	269	NUM
admet-621	1	28	admet	admet	X
admet-621	1	29	&	&	CCONJ
admet-621	1	30	dmpk	dmpk	PROPN
admet-621	1	31	6(4	6(4	PROPN
admet-621	1	32	)	)	PUNCT
admet-621	1	33	(	(	PUNCT
admet-621	1	34	2018	2018	NUM
admet-621	1	35	)	)	PUNCT
admet-621	1	36	269	269	NUM
admet-621	1	37	-	-	SYM
admet-621	1	38	278	278	NUM
admet-621	1	39	;	;	PUNCT
admet-621	1	40	doi	doi	NOUN
admet-621	1	41	:	:	PUNCT
admet-621	1	42	http://dx.doi.org/10.5599/admet.621	http://dx.doi.org/10.5599/admet.621	ADJ
admet-621	1	43	open	open	ADJ
admet-621	1	44	access	access	NOUN
admet-621	1	45	:	:	PUNCT
admet-621	1	46	issn	issn	NOUN
admet-621	1	47	:	:	PUNCT
admet-621	1	48	1848	1848	NUM
admet-621	1	49	-	-	SYM
admet-621	1	50	7718	7718	NUM
admet-621	1	51	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-621	1	52	original	original	ADJ
admet-621	1	53	scientific	scientific	ADJ
admet-621	1	54	paper	paper	NOUN
admet-621	1	55	effects	effect	NOUN
admet-621	1	56	of	of	ADP
admet-621	1	57	amount	amount	NOUN
admet-621	1	58	of	of	ADP
admet-621	1	59	excess	excess	NOUN
admet-621	1	60	solid	solid	ADJ
admet-621	1	61	,	,	PUNCT
admet-621	1	62	the	the	DET
admet-621	1	63	type	type	NOUN
admet-621	1	64	of	of	ADP
admet-621	1	65	stirring	stirring	NOUN
admet-621	1	66	and	and	CCONJ
admet-621	1	67	sedimentation	sedimentation	NOUN
admet-621	1	68	time	time	NOUN
admet-621	1	69	on	on	ADP
admet-621	1	70	solubility	solubility	NOUN
admet-621	1	71	of	of	ADP
admet-621	1	72	sodium	sodium	NOUN
admet-621	1	73	phenytoin	phenytoin	NOUN
admet-621	1	74	and	and	CCONJ
admet-621	1	75	lamotrigine	lamotrigine	PROPN
admet-621	1	76	shahrzad	shahrzad	PROPN
admet-621	1	77	moattar	moattar	PROPN
admet-621	1	78	mohammadi1,2	mohammadi1,2	PROPN
admet-621	1	79	,	,	PUNCT
admet-621	1	80	ali	ali	PROPN
admet-621	1	81	shayanfar3	shayanfar3	PROPN
admet-621	1	82	*	*	PROPN
admet-621	1	83	,	,	PUNCT
admet-621	1	84	shahram	shahram	PROPN
admet-621	1	85	emami3	emami3	PROPN
admet-621	1	86	,	,	PUNCT
admet-621	1	87	abolghasem	abolghasem	NOUN
admet-621	1	88	jouyban4	jouyban4	NOUN
admet-621	1	89	1	1	NUM
admet-621	1	90	biotechnolgy	biotechnolgy	NOUN
admet-621	1	91	research	research	NOUN
admet-621	1	92	center	center	NOUN
admet-621	1	93	,	,	PUNCT
admet-621	1	94	tabriz	tabriz	PROPN
admet-621	1	95	university	university	PROPN
admet-621	1	96	of	of	ADP
admet-621	1	97	medical	medical	ADJ
admet-621	1	98	sciences	sciences	PROPN
admet-621	1	99	,	,	PUNCT
admet-621	1	100	tabriz	tabriz	NOUN
admet-621	1	101	,	,	PUNCT
admet-621	1	102	iran	iran	PROPN
admet-621	1	103	2	2	NUM
admet-621	1	104	student	student	NOUN
admet-621	1	105	research	research	NOUN
admet-621	1	106	committee	committee	NOUN
admet-621	1	107	and	and	CCONJ
admet-621	1	108	faculty	faculty	NOUN
admet-621	1	109	of	of	ADP
admet-621	1	110	pharmacy	pharmacy	NOUN
admet-621	1	111	,	,	PUNCT
admet-621	1	112	tabriz	tabriz	PROPN
admet-621	1	113	university	university	PROPN
admet-621	1	114	of	of	ADP
admet-621	1	115	medical	medical	ADJ
admet-621	1	116	sciences	sciences	PROPN
admet-621	1	117	,	,	PUNCT
admet-621	1	118	tabriz	tabriz	NOUN
admet-621	1	119	,	,	PUNCT
admet-621	1	120	iran	iran	PROPN
admet-621	1	121	3	3	NUM
admet-621	1	122	drug	drug	NOUN
admet-621	1	123	applied	apply	VERB
admet-621	1	124	research	research	NOUN
admet-621	1	125	center	center	NOUN
admet-621	1	126	and	and	CCONJ
admet-621	1	127	faculty	faculty	NOUN
admet-621	1	128	of	of	ADP
admet-621	1	129	pharmacy	pharmacy	NOUN
admet-621	1	130	,	,	PUNCT
admet-621	1	131	tabriz	tabriz	PROPN
admet-621	1	132	university	university	PROPN
admet-621	1	133	of	of	ADP
admet-621	1	134	medical	medical	ADJ
admet-621	1	135	sciences	sciences	PROPN
admet-621	1	136	,	,	PUNCT
admet-621	1	137	tabriz	tabriz	NOUN
admet-621	1	138	,	,	PUNCT
admet-621	1	139	iran	iran	PROPN
admet-621	1	140	4	4	NUM
admet-621	1	141	pharmaceutical	pharmaceutical	NOUN
admet-621	1	142	analysis	analysis	NOUN
admet-621	1	143	research	research	NOUN
admet-621	1	144	center	center	NOUN
admet-621	1	145	and	and	CCONJ
admet-621	1	146	faculty	faculty	NOUN
admet-621	1	147	of	of	ADP
admet-621	1	148	pharmacy	pharmacy	NOUN
admet-621	1	149	,	,	PUNCT
admet-621	1	150	tabriz	tabriz	PROPN
admet-621	1	151	university	university	PROPN
admet-621	1	152	of	of	ADP
admet-621	1	153	medical	medical	ADJ
admet-621	1	154	science	science	NOUN
admet-621	1	155	,	,	PUNCT
admet-621	1	156	tabriz	tabriz	NOUN
admet-621	1	157	,	,	PUNCT
admet-621	1	158	iran	iran	PROPN
admet-621	1	159	*	*	PUNCT
admet-621	1	160	corresponding	correspond	VERB
admet-621	1	161	author	author	NOUN
admet-621	1	162	:	:	PUNCT
admet-621	1	163	e	e	NOUN
admet-621	1	164	-	-	NOUN
admet-621	1	165	mail	mail	NOUN
admet-621	1	166	:	:	PUNCT
admet-621	1	167	shayanfara@tbzmed.ac.ir	shayanfara@tbzmed.ac.ir	NOUN
admet-621	1	168	;	;	PUNCT
admet-621	1	169	tel	tel	PROPN
admet-621	1	170	.	.	PROPN
admet-621	1	171	:	:	PUNCT
admet-621	1	172	+984133341315	+984133341315	NUM
admet-621	1	173	;	;	PUNCT
admet-621	1	174	fax	fax	NOUN
admet-621	1	175	:	:	PUNCT
admet-621	1	176	+1	+1	ADJ
admet-621	1	177	-	-	PUNCT
admet-621	1	178	111	111	NUM
admet-621	1	179	-	-	PUNCT
admet-621	1	180	111	111	NUM
admet-621	1	181	-	-	SYM
admet-621	1	182	112	112	NUM
admet-621	1	183	received	receive	VERB
admet-621	1	184	:	:	PUNCT
admet-621	1	185	september	september	PROPN
admet-621	1	186	27	27	NUM
admet-621	1	187	,	,	PUNCT
admet-621	1	188	2018	2018	NUM
admet-621	1	189	;	;	PUNCT
admet-621	1	190	revised	revise	VERB
admet-621	1	191	:	:	PUNCT
admet-621	1	192	october	october	PROPN
admet-621	1	193	22	22	NUM
admet-621	1	194	,	,	PUNCT
admet-621	1	195	2018	2018	NUM
admet-621	1	196	;	;	PUNCT
admet-621	1	197	published	publish	VERB
admet-621	1	198	:	:	PUNCT
admet-621	1	199	november	november	PROPN
admet-621	1	200	03	03	NUM
admet-621	1	201	,	,	PUNCT
admet-621	1	202	2018	2018	NUM
admet-621	1	203	abstract	abstract	ADJ
admet-621	1	204	solubility	solubility	NOUN
admet-621	1	205	is	be	AUX
admet-621	1	206	the	the	DET
admet-621	1	207	maximum	maximum	ADJ
admet-621	1	208	quantity	quantity	NOUN
admet-621	1	209	of	of	ADP
admet-621	1	210	a	a	DET
admet-621	1	211	drug	drug	NOUN
admet-621	1	212	dissolved	dissolve	VERB
admet-621	1	213	in	in	ADP
admet-621	1	214	a	a	DET
admet-621	1	215	given	give	VERB
admet-621	1	216	volume	volume	NOUN
admet-621	1	217	of	of	ADP
admet-621	1	218	solvent	solvent	NOUN
admet-621	1	219	at	at	ADP
admet-621	1	220	a	a	DET
admet-621	1	221	specific	specific	ADJ
admet-621	1	222	temperature	temperature	NOUN
admet-621	1	223	.	.	PUNCT
admet-621	2	1	several	several	ADJ
admet-621	2	2	factors	factor	NOUN
admet-621	2	3	affect	affect	VERB
admet-621	2	4	equilibrium	equilibrium	NOUN
admet-621	2	5	solubility	solubility	NOUN
admet-621	2	6	.	.	PUNCT
admet-621	3	1	therefore	therefore	ADV
admet-621	3	2	,	,	PUNCT
admet-621	3	3	different	different	ADJ
admet-621	3	4	solubility	solubility	NOUN
admet-621	3	5	data	datum	NOUN
admet-621	3	6	have	have	AUX
admet-621	3	7	been	be	AUX
admet-621	3	8	reported	report	VERB
admet-621	3	9	for	for	ADP
admet-621	3	10	a	a	DET
admet-621	3	11	solute	solute	NOUN
admet-621	3	12	in	in	ADP
admet-621	3	13	a	a	DET
admet-621	3	14	certain	certain	ADJ
admet-621	3	15	solvent	solvent	NOUN
admet-621	3	16	and	and	CCONJ
admet-621	3	17	temperature	temperature	NOUN
admet-621	3	18	in	in	ADP
admet-621	3	19	the	the	DET
admet-621	3	20	literature	literature	NOUN
admet-621	3	21	.	.	PUNCT
admet-621	4	1	these	these	DET
admet-621	4	2	variations	variation	NOUN
admet-621	4	3	in	in	ADP
admet-621	4	4	solubility	solubility	NOUN
admet-621	4	5	are	be	AUX
admet-621	4	6	one	one	NUM
admet-621	4	7	of	of	ADP
admet-621	4	8	the	the	DET
admet-621	4	9	possible	possible	ADJ
admet-621	4	10	reasons	reason	NOUN
admet-621	4	11	for	for	ADP
admet-621	4	12	unsuccessful	unsuccessful	ADJ
admet-621	4	13	attempts	attempt	NOUN
admet-621	4	14	of	of	ADP
admet-621	4	15	medicinal	medicinal	ADJ
admet-621	4	16	chemists	chemist	NOUN
admet-621	4	17	for	for	ADP
admet-621	4	18	developing	develop	VERB
admet-621	4	19	models	model	NOUN
admet-621	4	20	as	as	ADV
admet-621	4	21	well	well	ADV
admet-621	4	22	as	as	ADP
admet-621	4	23	deviation	deviation	NOUN
admet-621	4	24	of	of	ADP
admet-621	4	25	experimental	experimental	ADJ
admet-621	4	26	works	work	NOUN
admet-621	4	27	for	for	ADP
admet-621	4	28	solubility	solubility	NOUN
admet-621	4	29	prediction	prediction	NOUN
admet-621	4	30	in	in	ADP
admet-621	4	31	aqueous	aqueous	ADJ
admet-621	4	32	,	,	PUNCT
admet-621	4	33	non	non	ADJ
admet-621	4	34	-	-	ADJ
admet-621	4	35	aqueous	aqueous	ADJ
admet-621	4	36	and	and	CCONJ
admet-621	4	37	solvent	solvent	ADJ
admet-621	4	38	mixtures	mixture	NOUN
admet-621	4	39	.	.	PUNCT
admet-621	5	1	the	the	DET
admet-621	5	2	present	present	ADJ
admet-621	5	3	research	research	NOUN
admet-621	5	4	aim	aim	NOUN
admet-621	5	5	is	be	AUX
admet-621	5	6	to	to	PART
admet-621	5	7	investigate	investigate	VERB
admet-621	5	8	the	the	DET
admet-621	5	9	effect	effect	NOUN
admet-621	5	10	of	of	ADP
admet-621	5	11	the	the	DET
admet-621	5	12	amount	amount	NOUN
admet-621	5	13	of	of	ADP
admet-621	5	14	excess	excess	NOUN
admet-621	5	15	solid	solid	ADJ
admet-621	5	16	and	and	CCONJ
admet-621	5	17	the	the	DET
admet-621	5	18	type	type	NOUN
admet-621	5	19	of	of	ADP
admet-621	5	20	stirring	stir	VERB
admet-621	5	21	on	on	ADP
admet-621	5	22	the	the	DET
admet-621	5	23	solubility	solubility	NOUN
admet-621	5	24	of	of	ADP
admet-621	5	25	drugs	drug	NOUN
admet-621	5	26	.	.	PUNCT
admet-621	6	1	the	the	DET
admet-621	6	2	solubility	solubility	NOUN
admet-621	6	3	of	of	ADP
admet-621	6	4	two	two	NUM
admet-621	6	5	antiepileptic	antiepileptic	ADJ
admet-621	6	6	drugs	drug	NOUN
admet-621	6	7	,	,	PUNCT
admet-621	6	8	namely	namely	ADV
admet-621	6	9	sodium	sodium	NOUN
admet-621	6	10	phenytoin	phenytoin	NOUN
admet-621	6	11	and	and	CCONJ
admet-621	6	12	lamotrigine	lamotrigine	NOUN
admet-621	6	13	was	be	AUX
admet-621	6	14	determined	determine	VERB
admet-621	6	15	in	in	ADP
admet-621	6	16	water	water	NOUN
admet-621	6	17	,	,	PUNCT
admet-621	6	18	ethanol	ethanol	NOUN
admet-621	6	19	,	,	PUNCT
admet-621	6	20	and	and	CCONJ
admet-621	6	21	hcl	hcl	PROPN
admet-621	6	22	0.1	0.1	NUM
admet-621	6	23	m	m	NOUN
admet-621	6	24	at	at	ADP
admet-621	6	25	37	37	NUM
admet-621	6	26	°	°	NOUN
admet-621	6	27	c	c	NOUN
admet-621	6	28	.	.	PUNCT
admet-621	7	1	different	different	ADJ
admet-621	7	2	excess	excess	ADJ
admet-621	7	3	amounts	amount	NOUN
admet-621	7	4	of	of	ADP
admet-621	7	5	drugs	drug	NOUN
admet-621	7	6	were	be	AUX
admet-621	7	7	added	add	VERB
admet-621	7	8	to	to	ADP
admet-621	7	9	the	the	DET
admet-621	7	10	constant	constant	ADJ
admet-621	7	11	volume	volume	NOUN
admet-621	7	12	of	of	ADP
admet-621	7	13	solvent	solvent	NOUN
admet-621	7	14	.	.	PUNCT
admet-621	8	1	additionally	additionally	ADV
admet-621	8	2	,	,	PUNCT
admet-621	8	3	different	different	ADJ
admet-621	8	4	stirring	stirring	NOUN
admet-621	8	5	methods	method	NOUN
admet-621	8	6	such	such	ADJ
admet-621	8	7	as	as	ADP
admet-621	8	8	magnetic	magnetic	ADJ
admet-621	8	9	stirrer	stirrer	NOUN
admet-621	8	10	and	and	CCONJ
admet-621	8	11	shake	shake	NOUN
admet-621	8	12	-	-	PUNCT
admet-621	8	13	flask	flask	NOUN
admet-621	8	14	and	and	CCONJ
admet-621	8	15	sedimentation	sedimentation	NOUN
admet-621	8	16	time	time	NOUN
admet-621	8	17	were	be	AUX
admet-621	8	18	investigated	investigate	VERB
admet-621	8	19	on	on	ADP
admet-621	8	20	the	the	DET
admet-621	8	21	solubility	solubility	NOUN
admet-621	8	22	values	value	NOUN
admet-621	8	23	.	.	PUNCT
admet-621	9	1	saturation	saturation	NOUN
admet-621	9	2	solubility	solubility	NOUN
admet-621	9	3	of	of	ADP
admet-621	9	4	drugs	drug	NOUN
admet-621	9	5	after	after	SCONJ
admet-621	9	6	dilution	dilution	NOUN
admet-621	9	7	with	with	ADP
admet-621	9	8	water	water	NOUN
admet-621	9	9	was	be	AUX
admet-621	9	10	measured	measure	VERB
admet-621	9	11	using	use	VERB
admet-621	9	12	a	a	DET
admet-621	9	13	spectrophotometer	spectrophotometer	NOUN
admet-621	9	14	,	,	PUNCT
admet-621	9	15	and	and	CCONJ
admet-621	9	16	the	the	DET
admet-621	9	17	concentration	concentration	NOUN
admet-621	9	18	was	be	AUX
admet-621	9	19	calculated	calculate	VERB
admet-621	9	20	according	accord	VERB
admet-621	9	21	to	to	ADP
admet-621	9	22	the	the	DET
admet-621	9	23	calibration	calibration	NOUN
admet-621	9	24	curve	curve	NOUN
admet-621	9	25	.	.	PUNCT
admet-621	10	1	amount	amount	NOUN
admet-621	10	2	of	of	ADP
admet-621	10	3	excess	excess	NOUN
admet-621	10	4	solid	solid	ADJ
admet-621	10	5	,	,	PUNCT
admet-621	10	6	especially	especially	ADV
admet-621	10	7	when	when	SCONJ
admet-621	10	8	the	the	DET
admet-621	10	9	drug	drug	NOUN
admet-621	10	10	is	be	AUX
admet-621	10	11	in	in	ADP
admet-621	10	12	ionized	ionized	ADJ
admet-621	10	13	form	form	NOUN
admet-621	10	14	,	,	PUNCT
admet-621	10	15	and	and	CCONJ
admet-621	10	16	sedimentation	sedimentation	NOUN
admet-621	10	17	time	time	NOUN
admet-621	10	18	after	after	SCONJ
admet-621	10	19	24	24	NUM
admet-621	10	20	h	h	NOUN
admet-621	10	21	have	have	VERB
admet-621	10	22	a	a	DET
admet-621	10	23	significant	significant	ADJ
admet-621	10	24	effect	effect	NOUN
admet-621	10	25	on	on	ADP
admet-621	10	26	solubility	solubility	NOUN
admet-621	10	27	values	value	NOUN
admet-621	10	28	.	.	PUNCT
admet-621	11	1	keywords	keyword	VERB
admet-621	11	2	antiepileptic	antiepileptic	ADJ
admet-621	11	3	drugs	drug	NOUN
admet-621	11	4	;	;	PUNCT
admet-621	11	5	equilibrium	equilibrium	NOUN
admet-621	11	6	solubility	solubility	NOUN
admet-621	11	7	;	;	PUNCT
admet-621	11	8	determination	determination	NOUN
admet-621	11	9	introduction	introduction	NOUN
admet-621	11	10	solubility	solubility	NOUN
admet-621	11	11	of	of	ADP
admet-621	11	12	drugs	drug	NOUN
admet-621	11	13	is	be	AUX
admet-621	11	14	an	an	DET
admet-621	11	15	important	important	ADJ
admet-621	11	16	aspect	aspect	NOUN
admet-621	11	17	from	from	ADP
admet-621	11	18	the	the	DET
admet-621	11	19	earliest	early	ADJ
admet-621	11	20	stages	stage	NOUN
admet-621	11	21	of	of	ADP
admet-621	11	22	drug	drug	NOUN
admet-621	11	23	discovery	discovery	NOUN
admet-621	11	24	to	to	ADP
admet-621	11	25	the	the	DET
admet-621	11	26	latest	late	ADJ
admet-621	11	27	stage	stage	NOUN
admet-621	11	28	of	of	ADP
admet-621	11	29	the	the	DET
admet-621	11	30	drug	drug	NOUN
admet-621	11	31	formulation	formulation	NOUN
admet-621	11	32	[	[	X
admet-621	11	33	1,2	1,2	NUM
admet-621	11	34	]	]	PUNCT
admet-621	11	35	.	.	PUNCT
admet-621	12	1	it	it	PRON
admet-621	12	2	is	be	AUX
admet-621	12	3	defined	define	VERB
admet-621	12	4	as	as	ADP
admet-621	12	5	the	the	DET
admet-621	12	6	maximum	maximum	ADJ
admet-621	12	7	quantity	quantity	NOUN
admet-621	12	8	of	of	ADP
admet-621	12	9	a	a	DET
admet-621	12	10	drug	drug	NOUN
admet-621	12	11	dissolved	dissolve	VERB
admet-621	12	12	in	in	ADP
admet-621	12	13	a	a	DET
admet-621	12	14	given	give	VERB
admet-621	12	15	volume	volume	NOUN
admet-621	12	16	of	of	ADP
admet-621	12	17	a	a	DET
admet-621	12	18	solvent	solvent	NOUN
admet-621	12	19	at	at	ADP
admet-621	12	20	a	a	DET
admet-621	12	21	certain	certain	ADJ
admet-621	12	22	temperature	temperature	NOUN
admet-621	12	23	[	[	X
admet-621	12	24	3	3	NUM
admet-621	12	25	]	]	PUNCT
admet-621	12	26	.	.	PUNCT
admet-621	13	1	solubility	solubility	NOUN
admet-621	13	2	data	datum	NOUN
admet-621	13	3	for	for	ADP
admet-621	13	4	a	a	DET
admet-621	13	5	solute	solute	NOUN
admet-621	13	6	,	,	PUNCT
admet-621	13	7	especially	especially	ADV
admet-621	13	8	for	for	ADP
admet-621	13	9	pharmaceuticals	pharmaceutical	NOUN
admet-621	13	10	,	,	PUNCT
admet-621	13	11	is	be	AUX
admet-621	13	12	a	a	DET
admet-621	13	13	significant	significant	ADJ
admet-621	13	14	physicochemical	physicochemical	ADJ
admet-621	13	15	property	property	NOUN
admet-621	13	16	in	in	ADP
admet-621	13	17	crystallization	crystallization	NOUN
admet-621	13	18	,	,	PUNCT
admet-621	13	19	extraction	extraction	NOUN
admet-621	13	20	of	of	ADP
admet-621	13	21	an	an	DET
admet-621	13	22	analyte	analyte	NOUN
admet-621	13	23	from	from	ADP
admet-621	13	24	different	different	ADJ
admet-621	13	25	matrices	matrix	NOUN
admet-621	13	26	,	,	PUNCT
admet-621	13	27	evaluation	evaluation	NOUN
admet-621	13	28	of	of	ADP
admet-621	13	29	oral	oral	ADJ
admet-621	13	30	bioavailability	bioavailability	NOUN
admet-621	13	31	and	and	CCONJ
admet-621	13	32	preparation	preparation	NOUN
admet-621	13	33	of	of	ADP
admet-621	13	34	liquid	liquid	ADJ
admet-621	13	35	and	and	CCONJ
admet-621	13	36	semi	semi	ADJ
admet-621	13	37	-	-	ADJ
admet-621	13	38	solid	solid	ADJ
admet-621	13	39	dosage	dosage	NOUN
admet-621	13	40	forms	form	NOUN
admet-621	13	41	.	.	PUNCT
admet-621	14	1	furthermore	furthermore	ADV
admet-621	14	2	,	,	PUNCT
admet-621	14	3	solubility	solubility	NOUN
admet-621	14	4	in	in	ADP
admet-621	14	5	water	water	NOUN
admet-621	14	6	is	be	AUX
admet-621	14	7	needed	need	VERB
admet-621	14	8	to	to	PART
admet-621	14	9	make	make	VERB
admet-621	14	10	a	a	DET
admet-621	14	11	solution	solution	NOUN
admet-621	14	12	of	of	ADP
admet-621	14	13	the	the	DET
admet-621	14	14	drug	drug	NOUN
admet-621	14	15	or	or	CCONJ
admet-621	14	16	drug	drug	NOUN
admet-621	14	17	-	-	PUNCT
admet-621	14	18	like	like	ADJ
admet-621	14	19	molecule	molecule	NOUN
admet-621	14	20	to	to	PART
admet-621	14	21	be	be	AUX
admet-621	14	22	tested	test	VERB
admet-621	14	23	for	for	ADP
admet-621	14	24	its	its	PRON
admet-621	14	25	pharmacological	pharmacological	ADJ
admet-621	14	26	/	/	SYM
admet-621	14	27	toxicological	toxicological	ADJ
admet-621	14	28	activities	activity	NOUN
admet-621	14	29	.	.	PUNCT
admet-621	15	1	despite	despite	SCONJ
admet-621	15	2	simple	simple	ADJ
admet-621	15	3	methods	method	NOUN
admet-621	15	4	developed	develop	VERB
admet-621	15	5	for	for	ADP
admet-621	15	6	experimental	experimental	ADJ
admet-621	15	7	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-621	15	8	mailto:shayanfara@tbzmed.ac.ir	mailto:shayanfara@tbzmed.ac.ir	PROPN
admet-621	15	9	mailto:shayanfara@tbzmed.ac.ir	mailto:shayanfara@tbzmed.ac.ir	PROPN
admet-621	15	10	ali	ali	PROPN
admet-621	15	11	shayanfar	shayanfar	PROPN
admet-621	15	12	et	et	PROPN
admet-621	15	13	al	al	PROPN
admet-621	15	14	.	.	PROPN
admet-621	15	15	admet	admet	PROPN
admet-621	15	16	&	&	CCONJ
admet-621	15	17	dmpk	dmpk	PROPN
admet-621	15	18	6(4	6(4	PROPN
admet-621	15	19	)	)	PUNCT
admet-621	15	20	(	(	PUNCT
admet-621	15	21	2018	2018	NUM
admet-621	15	22	)	)	PUNCT
admet-621	15	23	269	269	NUM
admet-621	15	24	-	-	SYM
admet-621	15	25	278	278	NUM
admet-621	15	26	270	270	NUM
admet-621	15	27	determination	determination	NOUN
admet-621	15	28	of	of	ADP
admet-621	15	29	the	the	DET
admet-621	15	30	solubility	solubility	NOUN
admet-621	15	31	of	of	ADP
admet-621	15	32	drugs	drug	NOUN
admet-621	15	33	[	[	X
admet-621	15	34	4	4	NUM
admet-621	15	35	]	]	PUNCT
admet-621	15	36	,	,	PUNCT
admet-621	15	37	various	various	ADJ
admet-621	15	38	parameters	parameter	NOUN
admet-621	15	39	can	can	AUX
admet-621	15	40	affect	affect	VERB
admet-621	15	41	accuracy	accuracy	NOUN
admet-621	15	42	of	of	ADP
admet-621	15	43	the	the	DET
admet-621	15	44	obtained	obtain	VERB
admet-621	15	45	data	datum	NOUN
admet-621	15	46	[	[	X
admet-621	15	47	5	5	NUM
admet-621	15	48	]	]	PUNCT
admet-621	15	49	.	.	PUNCT
admet-621	16	1	several	several	ADJ
admet-621	16	2	different	different	ADJ
admet-621	16	3	sets	set	NOUN
admet-621	16	4	of	of	ADP
admet-621	16	5	solubility	solubility	NOUN
admet-621	16	6	data	datum	NOUN
admet-621	16	7	have	have	AUX
admet-621	16	8	been	be	AUX
admet-621	16	9	reported	report	VERB
admet-621	16	10	for	for	ADP
admet-621	16	11	a	a	DET
admet-621	16	12	drug	drug	NOUN
admet-621	16	13	at	at	ADP
admet-621	16	14	a	a	DET
admet-621	16	15	certain	certain	ADJ
admet-621	16	16	solvent	solvent	NOUN
admet-621	16	17	and	and	CCONJ
admet-621	16	18	temperature	temperature	NOUN
admet-621	16	19	in	in	ADP
admet-621	16	20	the	the	DET
admet-621	16	21	literature	literature	NOUN
admet-621	16	22	[	[	X
admet-621	16	23	6	6	NUM
admet-621	16	24	-	-	SYM
admet-621	16	25	8	8	NUM
admet-621	16	26	]	]	PUNCT
admet-621	16	27	.	.	PUNCT
admet-621	17	1	these	these	DET
admet-621	17	2	solubility	solubility	NOUN
admet-621	17	3	variations	variation	NOUN
admet-621	17	4	are	be	AUX
admet-621	17	5	one	one	NUM
admet-621	17	6	of	of	ADP
admet-621	17	7	the	the	DET
admet-621	17	8	possible	possible	ADJ
admet-621	17	9	reasons	reason	NOUN
admet-621	17	10	for	for	ADP
admet-621	17	11	unsuccessful	unsuccessful	ADJ
admet-621	17	12	attempts	attempt	NOUN
admet-621	17	13	of	of	ADP
admet-621	17	14	medicinal	medicinal	ADJ
admet-621	17	15	chemist	chemist	NOUN
admet-621	17	16	in	in	ADP
admet-621	17	17	developing	develop	VERB
admet-621	17	18	models	model	NOUN
admet-621	17	19	for	for	ADP
admet-621	17	20	solubility	solubility	NOUN
admet-621	17	21	prediction	prediction	NOUN
admet-621	17	22	in	in	ADP
admet-621	17	23	water	water	NOUN
admet-621	17	24	,	,	PUNCT
admet-621	17	25	non	non	ADJ
admet-621	17	26	-	-	ADJ
admet-621	17	27	aqueous	aqueous	ADJ
admet-621	17	28	solvents	solvent	NOUN
admet-621	17	29	and	and	CCONJ
admet-621	17	30	solvent	solvent	NOUN
admet-621	17	31	mixtures	mixture	NOUN
admet-621	17	32	with	with	ADP
admet-621	17	33	deviation	deviation	NOUN
admet-621	17	34	in	in	ADP
admet-621	17	35	agreement	agreement	NOUN
admet-621	17	36	with	with	ADP
admet-621	17	37	experimental	experimental	ADJ
admet-621	17	38	works	work	NOUN
admet-621	17	39	.	.	PUNCT
admet-621	18	1	for	for	ADP
admet-621	18	2	example	example	NOUN
admet-621	18	3	,	,	PUNCT
admet-621	18	4	the	the	DET
admet-621	18	5	best	good	ADJ
admet-621	18	6	model	model	NOUN
admet-621	18	7	for	for	ADP
admet-621	18	8	aqueous	aqueous	ADJ
admet-621	18	9	solubility	solubility	NOUN
admet-621	18	10	prediction	prediction	NOUN
admet-621	18	11	has	have	VERB
admet-621	18	12	a	a	DET
admet-621	18	13	prediction	prediction	NOUN
admet-621	18	14	error	error	NOUN
admet-621	18	15	more	more	ADJ
admet-621	18	16	than	than	ADP
admet-621	18	17	100	100	NUM
admet-621	18	18	%	%	NOUN
admet-621	19	1	[	[	X
admet-621	19	2	9	9	NUM
admet-621	19	3	]	]	PUNCT
admet-621	19	4	,	,	PUNCT
admet-621	19	5	and	and	CCONJ
admet-621	19	6	estimation	estimation	NOUN
admet-621	19	7	error	error	NOUN
admet-621	19	8	for	for	ADP
admet-621	19	9	solubility	solubility	NOUN
admet-621	19	10	in	in	ADP
admet-621	19	11	the	the	DET
admet-621	19	12	solvent	solvent	NOUN
admet-621	19	13	mixture	mixture	NOUN
admet-621	19	14	is	be	AUX
admet-621	19	15	higher	high	ADJ
admet-621	19	16	than	than	ADP
admet-621	19	17	25	25	NUM
admet-621	19	18	%	%	NOUN
admet-621	19	19	for	for	ADP
admet-621	19	20	pharmaceuticals	pharmaceutical	NOUN
admet-621	19	21	[	[	X
admet-621	19	22	6	6	NUM
admet-621	19	23	]	]	PUNCT
admet-621	19	24	.	.	PUNCT
admet-621	20	1	there	there	PRON
admet-621	20	2	are	be	VERB
admet-621	20	3	various	various	ADJ
admet-621	20	4	methods	method	NOUN
admet-621	20	5	for	for	ADP
admet-621	20	6	solubility	solubility	NOUN
admet-621	20	7	determination	determination	NOUN
admet-621	20	8	of	of	ADP
admet-621	20	9	pharmaceuticals	pharmaceutical	NOUN
admet-621	20	10	[	[	X
admet-621	20	11	10,11	10,11	NOUN
admet-621	20	12	]	]	PUNCT
admet-621	20	13	.	.	PUNCT
admet-621	21	1	the	the	DET
admet-621	21	2	shake	shake	NOUN
admet-621	21	3	-	-	PUNCT
admet-621	21	4	flask	flask	NOUN
admet-621	21	5	method	method	NOUN
admet-621	21	6	is	be	AUX
admet-621	21	7	a	a	DET
admet-621	21	8	common	common	ADJ
admet-621	21	9	method	method	NOUN
admet-621	21	10	for	for	ADP
admet-621	21	11	solubility	solubility	NOUN
admet-621	21	12	determination	determination	NOUN
admet-621	21	13	which	which	PRON
admet-621	21	14	an	an	DET
admet-621	21	15	excess	excess	ADJ
admet-621	21	16	amount	amount	NOUN
admet-621	21	17	of	of	ADP
admet-621	21	18	drug	drug	NOUN
admet-621	21	19	is	be	AUX
admet-621	21	20	added	add	VERB
admet-621	21	21	to	to	ADP
admet-621	21	22	a	a	DET
admet-621	21	23	certain	certain	ADJ
admet-621	21	24	solvent	solvent	NOUN
admet-621	21	25	and	and	CCONJ
admet-621	21	26	after	after	ADP
admet-621	21	27	appropriate	appropriate	ADJ
admet-621	21	28	shaking	shake	VERB
admet-621	21	29	at	at	ADP
admet-621	21	30	a	a	DET
admet-621	21	31	constant	constant	ADJ
admet-621	21	32	temperature	temperature	NOUN
admet-621	21	33	to	to	PART
admet-621	21	34	reach	reach	VERB
admet-621	21	35	the	the	DET
admet-621	21	36	equilibrium	equilibrium	NOUN
admet-621	21	37	condition	condition	NOUN
admet-621	21	38	,	,	PUNCT
admet-621	21	39	and	and	CCONJ
admet-621	21	40	the	the	DET
admet-621	21	41	saturated	saturated	ADJ
admet-621	21	42	concentration	concentration	NOUN
admet-621	21	43	is	be	AUX
admet-621	21	44	determined	determine	VERB
admet-621	21	45	by	by	ADP
admet-621	21	46	a	a	DET
admet-621	21	47	valid	valid	ADJ
admet-621	21	48	analytical	analytical	ADJ
admet-621	21	49	method	method	NOUN
admet-621	21	50	[	[	X
admet-621	21	51	11	11	NUM
admet-621	21	52	]	]	PUNCT
admet-621	21	53	.	.	PUNCT
admet-621	22	1	in	in	ADP
admet-621	22	2	some	some	DET
admet-621	22	3	cases	case	NOUN
admet-621	22	4	,	,	PUNCT
admet-621	22	5	variation	variation	NOUN
admet-621	22	6	of	of	ADP
admet-621	22	7	solubility	solubility	NOUN
admet-621	22	8	data	datum	NOUN
admet-621	22	9	originates	originate	NOUN
admet-621	22	10	from	from	ADP
admet-621	22	11	the	the	DET
admet-621	22	12	nature	nature	NOUN
admet-621	22	13	of	of	ADP
admet-621	22	14	studied	study	VERB
admet-621	22	15	compounds	compound	NOUN
admet-621	22	16	,	,	PUNCT
admet-621	22	17	such	such	ADJ
admet-621	22	18	as	as	ADP
admet-621	22	19	polymorphism	polymorphism	NOUN
admet-621	22	20	and	and	CCONJ
admet-621	22	21	formations	formation	NOUN
admet-621	22	22	of	of	ADP
admet-621	22	23	drug	drug	NOUN
admet-621	22	24	aggregates	aggregate	NOUN
admet-621	22	25	,	,	PUNCT
admet-621	22	26	micelles	micelle	NOUN
admet-621	22	27	,	,	PUNCT
admet-621	22	28	drug	drug	NOUN
admet-621	22	29	-	-	PUNCT
admet-621	22	30	buffer	buffer	NOUN
admet-621	22	31	complexes	complex	NOUN
admet-621	22	32	,	,	PUNCT
admet-621	22	33	stability	stability	NOUN
admet-621	22	34	,	,	PUNCT
admet-621	22	35	solute	solute	NOUN
admet-621	22	36	and	and	CCONJ
admet-621	22	37	solvent	solvent	ADJ
admet-621	22	38	impurities	impurity	NOUN
admet-621	22	39	;	;	PUNCT
admet-621	22	40	they	they	PRON
admet-621	22	41	can	can	AUX
admet-621	22	42	affect	affect	VERB
admet-621	22	43	the	the	DET
admet-621	22	44	solubility	solubility	NOUN
admet-621	22	45	value	value	NOUN
admet-621	22	46	.	.	PUNCT
admet-621	23	1	another	another	DET
admet-621	23	2	problem	problem	NOUN
admet-621	23	3	in	in	ADP
admet-621	23	4	solubility	solubility	NOUN
admet-621	23	5	determination	determination	NOUN
admet-621	23	6	is	be	AUX
admet-621	23	7	invalidity	invalidity	NOUN
admet-621	23	8	of	of	ADP
admet-621	23	9	the	the	DET
admet-621	23	10	applied	apply	VERB
admet-621	23	11	method	method	NOUN
admet-621	23	12	for	for	ADP
admet-621	23	13	quantification	quantification	NOUN
admet-621	23	14	of	of	ADP
admet-621	23	15	drug	drug	NOUN
admet-621	23	16	concentration	concentration	NOUN
admet-621	23	17	.	.	PUNCT
admet-621	24	1	other	other	ADJ
admet-621	24	2	sources	source	NOUN
admet-621	24	3	of	of	ADP
admet-621	24	4	variations	variation	NOUN
admet-621	24	5	,	,	PUNCT
admet-621	24	6	which	which	PRON
admet-621	24	7	can	can	AUX
admet-621	24	8	affect	affect	VERB
admet-621	24	9	solubility	solubility	NOUN
admet-621	24	10	values	value	NOUN
admet-621	24	11	related	relate	VERB
admet-621	24	12	to	to	ADP
admet-621	24	13	the	the	DET
admet-621	24	14	solubility	solubility	NOUN
admet-621	24	15	determination	determination	NOUN
admet-621	24	16	process	process	NOUN
admet-621	24	17	such	such	ADJ
admet-621	24	18	as	as	ADP
admet-621	24	19	time	time	NOUN
admet-621	24	20	of	of	ADP
admet-621	24	21	equilibrium	equilibrium	NOUN
admet-621	24	22	,	,	PUNCT
admet-621	24	23	incomplete	incomplete	ADJ
admet-621	24	24	dissolution	dissolution	NOUN
admet-621	24	25	over	over	ADP
admet-621	24	26	the	the	DET
admet-621	24	27	equilibration	equilibration	NOUN
admet-621	24	28	time	time	NOUN
admet-621	24	29	and	and	CCONJ
admet-621	24	30	inappropriate	inappropriate	ADJ
admet-621	24	31	phase	phase	NOUN
admet-621	24	32	separation	separation	NOUN
admet-621	24	33	solution	solution	NOUN
admet-621	24	34	handling	handling	NOUN
admet-621	24	35	and	and	CCONJ
admet-621	24	36	adsorption	adsorption	NOUN
admet-621	24	37	to	to	ADP
admet-621	24	38	untreated	untreated	ADJ
admet-621	24	39	surfaces	surface	NOUN
admet-621	24	40	,	,	PUNCT
admet-621	24	41	amount	amount	NOUN
admet-621	24	42	of	of	ADP
admet-621	24	43	residual	residual	ADJ
admet-621	24	44	solid	solid	ADJ
admet-621	24	45	,	,	PUNCT
admet-621	24	46	speed	speed	NOUN
admet-621	24	47	and	and	CCONJ
admet-621	24	48	stirring	stir	VERB
admet-621	24	49	or	or	CCONJ
admet-621	24	50	shaking	shake	VERB
admet-621	24	51	patterns	pattern	NOUN
admet-621	24	52	of	of	ADP
admet-621	24	53	the	the	DET
admet-621	24	54	suspension	suspension	NOUN
admet-621	24	55	[	[	X
admet-621	24	56	5,7,12	5,7,12	NUM
admet-621	24	57	]	]	X
admet-621	24	58	.	.	PUNCT
admet-621	25	1	although	although	SCONJ
admet-621	25	2	,	,	PUNCT
admet-621	25	3	various	various	ADJ
admet-621	25	4	sets	set	NOUN
admet-621	25	5	of	of	ADP
admet-621	25	6	solubility	solubility	NOUN
admet-621	25	7	data	datum	NOUN
admet-621	25	8	for	for	ADP
admet-621	25	9	chemical	chemical	NOUN
admet-621	25	10	and	and	CCONJ
admet-621	25	11	pharmaceutical	pharmaceutical	NOUN
admet-621	25	12	materials	material	NOUN
admet-621	25	13	in	in	ADP
admet-621	25	14	water	water	NOUN
admet-621	25	15	and	and	CCONJ
admet-621	25	16	organic	organic	ADJ
admet-621	25	17	solvents	solvent	NOUN
admet-621	25	18	are	be	AUX
admet-621	25	19	annually	annually	ADV
admet-621	25	20	collected	collect	VERB
admet-621	25	21	by	by	ADP
admet-621	25	22	different	different	ADJ
admet-621	25	23	research	research	NOUN
admet-621	25	24	groups	group	NOUN
admet-621	25	25	and	and	CCONJ
admet-621	25	26	reported	report	VERB
admet-621	25	27	in	in	ADP
admet-621	25	28	the	the	DET
admet-621	25	29	literature	literature	NOUN
admet-621	25	30	,	,	PUNCT
admet-621	25	31	there	there	PRON
admet-621	25	32	are	be	VERB
admet-621	25	33	few	few	ADJ
admet-621	25	34	investigations	investigation	NOUN
admet-621	25	35	into	into	ADP
admet-621	25	36	the	the	DET
admet-621	25	37	effect	effect	NOUN
admet-621	25	38	of	of	ADP
admet-621	25	39	different	different	ADJ
admet-621	25	40	parameters	parameter	NOUN
admet-621	25	41	on	on	ADP
admet-621	25	42	solubility	solubility	NOUN
admet-621	25	43	determination	determination	NOUN
admet-621	25	44	of	of	ADP
admet-621	25	45	drugs	drug	NOUN
admet-621	25	46	.	.	PUNCT
admet-621	26	1	baka	baka	PROPN
admet-621	26	2	et	et	PROPN
admet-621	26	3	al	al	PROPN
admet-621	26	4	.	.	PUNCT
admet-621	27	1	[	[	X
admet-621	27	2	8	8	NUM
admet-621	27	3	]	]	PUNCT
admet-621	27	4	investigated	investigate	VERB
admet-621	27	5	the	the	DET
admet-621	27	6	effect	effect	NOUN
admet-621	27	7	of	of	ADP
admet-621	27	8	various	various	ADJ
admet-621	27	9	parameters	parameter	NOUN
admet-621	27	10	such	such	ADJ
admet-621	27	11	as	as	ADP
admet-621	27	12	amount	amount	NOUN
admet-621	27	13	of	of	ADP
admet-621	27	14	solid	solid	ADJ
admet-621	27	15	excess	excess	ADJ
admet-621	27	16	,	,	PUNCT
admet-621	27	17	stirring	stirring	NOUN
admet-621	27	18	time	time	NOUN
admet-621	27	19	,	,	PUNCT
admet-621	27	20	temperature	temperature	NOUN
admet-621	27	21	,	,	PUNCT
admet-621	27	22	and	and	CCONJ
admet-621	27	23	sedimentation	sedimentation	NOUN
admet-621	27	24	time	time	NOUN
admet-621	27	25	on	on	ADP
admet-621	27	26	solubility	solubility	NOUN
admet-621	27	27	of	of	ADP
admet-621	27	28	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-621	27	29	as	as	ADP
admet-621	27	30	a	a	DET
admet-621	27	31	model	model	NOUN
admet-621	27	32	drug	drug	NOUN
admet-621	27	33	.	.	PUNCT
admet-621	28	1	some	some	DET
admet-621	28	2	reports	report	NOUN
admet-621	28	3	have	have	AUX
admet-621	28	4	been	be	AUX
admet-621	28	5	investigated	investigate	VERB
admet-621	28	6	the	the	DET
admet-621	28	7	effect	effect	NOUN
admet-621	28	8	of	of	ADP
admet-621	28	9	excess	excess	NOUN
admet-621	28	10	solid	solid	ADJ
admet-621	28	11	on	on	ADP
admet-621	28	12	solubility	solubility	NOUN
admet-621	28	13	of	of	ADP
admet-621	28	14	drugs	drug	NOUN
admet-621	28	15	[	[	X
admet-621	28	16	13,14	13,14	NUM
admet-621	28	17	]	]	X
admet-621	28	18	;	;	PUNCT
admet-621	28	19	and	and	CCONJ
admet-621	28	20	the	the	DET
admet-621	28	21	reported	report	VERB
admet-621	28	22	results	result	NOUN
admet-621	28	23	are	be	AUX
admet-621	28	24	discussed	discuss	VERB
admet-621	28	25	in	in	ADP
admet-621	28	26	review	review	NOUN
admet-621	28	27	articles	article	NOUN
admet-621	28	28	[	[	X
admet-621	28	29	11,15	11,15	NUM
admet-621	28	30	]	]	PUNCT
admet-621	28	31	.	.	PUNCT
admet-621	29	1	lamotrigine	lamotrigine	PROPN
admet-621	29	2	is	be	AUX
admet-621	29	3	a	a	DET
admet-621	29	4	basic	basic	ADJ
admet-621	29	5	drug	drug	NOUN
admet-621	29	6	(	(	PUNCT
admet-621	29	7	pka=5.7	pka=5.7	ADV
admet-621	29	8	)	)	PUNCT
admet-621	30	1	[	[	X
admet-621	30	2	16	16	NUM
admet-621	30	3	]	]	X
admet-621	30	4	existing	exist	VERB
admet-621	30	5	in	in	ADP
admet-621	30	6	unionized	unionized	ADJ
admet-621	30	7	form	form	NOUN
admet-621	30	8	in	in	ADP
admet-621	30	9	water	water	NOUN
admet-621	30	10	,	,	PUNCT
admet-621	30	11	while	while	SCONJ
admet-621	30	12	it	it	PRON
admet-621	30	13	is	be	AUX
admet-621	30	14	in	in	ADP
admet-621	30	15	ionized	ionized	ADJ
admet-621	30	16	form	form	NOUN
admet-621	30	17	in	in	ADP
admet-621	30	18	0.1	0.1	NUM
admet-621	30	19	m	m	NUM
admet-621	30	20	hcl	hcl	PROPN
admet-621	30	21	.	.	PUNCT
admet-621	31	1	sodium	sodium	PROPN
admet-621	31	2	phenytoin	phenytoin	NOUN
admet-621	31	3	is	be	AUX
admet-621	31	4	a	a	DET
admet-621	31	5	salt	salt	NOUN
admet-621	31	6	form	form	NOUN
admet-621	31	7	of	of	ADP
admet-621	31	8	phenytoin	phenytoin	NOUN
admet-621	31	9	(	(	PUNCT
admet-621	31	10	an	an	DET
admet-621	31	11	acidic	acidic	ADJ
admet-621	31	12	compound	compound	NOUN
admet-621	31	13	with	with	ADP
admet-621	31	14	pka=8.3	pka=8.3	PROPN
admet-621	31	15	[	[	SYM
admet-621	31	16	16	16	NUM
admet-621	31	17	]	]	PUNCT
admet-621	31	18	)	)	PUNCT
admet-621	31	19	being	be	AUX
admet-621	31	20	partially	partially	ADV
admet-621	31	21	ionized	ionize	VERB
admet-621	31	22	form	form	NOUN
admet-621	31	23	in	in	ADP
admet-621	31	24	water	water	NOUN
admet-621	31	25	.	.	PUNCT
admet-621	32	1	in	in	ADP
admet-621	32	2	addition	addition	NOUN
admet-621	32	3	,	,	PUNCT
admet-621	32	4	it	it	PRON
admet-621	32	5	changes	change	VERB
admet-621	32	6	to	to	ADP
admet-621	32	7	the	the	DET
admet-621	32	8	parent	parent	NOUN
admet-621	32	9	drug	drug	NOUN
admet-621	32	10	(	(	PUNCT
admet-621	32	11	un	un	ADJ
admet-621	32	12	-	-	ADJ
admet-621	32	13	ionized	ionized	ADJ
admet-621	32	14	form	form	NOUN
admet-621	32	15	)	)	PUNCT
admet-621	32	16	in	in	ADP
admet-621	32	17	acidic	acidic	ADJ
admet-621	32	18	medium	medium	NOUN
admet-621	32	19	.	.	PUNCT
admet-621	33	1	in	in	ADP
admet-621	33	2	this	this	DET
admet-621	33	3	study	study	NOUN
admet-621	33	4	,	,	PUNCT
admet-621	33	5	the	the	DET
admet-621	33	6	effects	effect	NOUN
admet-621	33	7	of	of	ADP
admet-621	33	8	the	the	DET
admet-621	33	9	amount	amount	NOUN
admet-621	33	10	of	of	ADP
admet-621	33	11	solid	solid	ADJ
admet-621	33	12	excess	excess	NOUN
admet-621	33	13	,	,	PUNCT
admet-621	33	14	shaking	shake	VERB
admet-621	33	15	patterns	pattern	NOUN
admet-621	33	16	of	of	ADP
admet-621	33	17	solution	solution	NOUN
admet-621	33	18	and	and	CCONJ
admet-621	33	19	sedimentation	sedimentation	NOUN
admet-621	33	20	time	time	NOUN
admet-621	33	21	were	be	AUX
admet-621	33	22	investigated	investigate	VERB
admet-621	33	23	on	on	ADP
admet-621	33	24	solubility	solubility	NOUN
admet-621	33	25	of	of	ADP
admet-621	33	26	two	two	NUM
admet-621	33	27	antiepileptic	antiepileptic	ADJ
admet-621	33	28	drugs	drug	NOUN
admet-621	33	29	,	,	PUNCT
admet-621	33	30	namely	namely	ADV
admet-621	33	31	sodium	sodium	NOUN
admet-621	33	32	phenytoin	phenytoin	NOUN
admet-621	33	33	and	and	CCONJ
admet-621	33	34	lamotrigine	lamotrigine	NOUN
admet-621	33	35	in	in	ADP
admet-621	33	36	water	water	NOUN
admet-621	33	37	,	,	PUNCT
admet-621	33	38	ethanol	ethanol	NOUN
admet-621	33	39	and	and	CCONJ
admet-621	33	40	acidic	acidic	ADJ
admet-621	33	41	medium	medium	NOUN
admet-621	33	42	(	(	PUNCT
admet-621	33	43	hcl	hcl	PROPN
admet-621	33	44	0.1	0.1	NUM
admet-621	33	45	m	m	PROPN
admet-621	33	46	)	)	PUNCT
admet-621	33	47	.	.	PUNCT
admet-621	34	1	experimental	experimental	ADJ
admet-621	34	2	samples	sample	NOUN
admet-621	34	3	and	and	CCONJ
admet-621	34	4	chemicals	chemical	NOUN
admet-621	34	5	sodium	sodium	NOUN
admet-621	34	6	phenytoin	phenytoin	NOUN
admet-621	34	7	(	(	PUNCT
admet-621	34	8	99	99	NUM
admet-621	34	9	%	%	NOUN
admet-621	34	10	)	)	PUNCT
admet-621	34	11	and	and	CCONJ
admet-621	34	12	lamotrigine	lamotrigine	PROPN
admet-621	34	13	(	(	PUNCT
admet-621	34	14	99	99	NUM
admet-621	34	15	%	%	NOUN
admet-621	34	16	)	)	PUNCT
admet-621	34	17	were	be	AUX
admet-621	34	18	purchased	purchase	VERB
admet-621	34	19	from	from	ADP
admet-621	34	20	alhavi	alhavi	ADJ
admet-621	34	21	pharmaceutical	pharmaceutical	NOUN
admet-621	34	22	company	company	NOUN
admet-621	34	23	(	(	PUNCT
admet-621	34	24	tehran	tehran	PROPN
admet-621	34	25	,	,	PUNCT
admet-621	34	26	iran	iran	PROPN
admet-621	34	27	)	)	PUNCT
admet-621	34	28	.	.	PUNCT
admet-621	35	1	ethanol	ethanol	NOUN
admet-621	35	2	(	(	PUNCT
admet-621	35	3	99	99	NUM
admet-621	35	4	%	%	NOUN
admet-621	35	5	)	)	PUNCT
admet-621	35	6	was	be	AUX
admet-621	35	7	provided	provide	VERB
admet-621	35	8	from	from	ADP
admet-621	35	9	scharlau	scharlau	PROPN
admet-621	35	10	(	(	PUNCT
admet-621	35	11	barcelona	barcelona	PROPN
admet-621	35	12	,	,	PUNCT
admet-621	35	13	spain	spain	PROPN
admet-621	35	14	)	)	PUNCT
admet-621	35	15	and	and	CCONJ
admet-621	35	16	hcl	hcl	PROPN
admet-621	35	17	(	(	PUNCT
admet-621	35	18	37	37	NUM
admet-621	35	19	%	%	NOUN
admet-621	35	20	)	)	PUNCT
admet-621	35	21	was	be	AUX
admet-621	35	22	supplied	supply	VERB
admet-621	35	23	from	from	ADP
admet-621	35	24	merck	merck	PROPN
admet-621	35	25	(	(	PUNCT
admet-621	35	26	darmstadt	darmstadt	PROPN
admet-621	35	27	,	,	PUNCT
admet-621	35	28	germany	germany	PROPN
admet-621	35	29	)	)	PUNCT
admet-621	35	30	,	,	PUNCT
admet-621	35	31	and	and	CCONJ
admet-621	35	32	double	double	ADJ
admet-621	35	33	distilled	distil	VERB
admet-621	35	34	water	water	NOUN
admet-621	35	35	was	be	AUX
admet-621	35	36	used	use	VERB
admet-621	35	37	as	as	SCONJ
admet-621	35	38	received	receive	VERB
admet-621	35	39	in	in	ADP
admet-621	35	40	the	the	DET
admet-621	35	41	lab	lab	NOUN
admet-621	35	42	.	.	PUNCT
admet-621	36	1	apparatus	apparatus	PROPN
admet-621	36	2	a	a	DET
admet-621	36	3	shaker	shaker	NOUN
admet-621	36	4	incubator	incubator	NOUN
admet-621	36	5	(	(	PUNCT
admet-621	36	6	heidolph	heidolph	NOUN
admet-621	36	7	,	,	PUNCT
admet-621	36	8	germany	germany	PROPN
admet-621	36	9	)	)	PUNCT
admet-621	36	10	or	or	CCONJ
admet-621	36	11	a	a	DET
admet-621	36	12	magnetic	magnetic	ADJ
admet-621	36	13	stirrer	stirrer	NOUN
admet-621	36	14	(	(	PUNCT
admet-621	36	15	heidolph	heidolph	VERB
admet-621	36	16	mr	mr	PROPN
admet-621	36	17	hei	hei	PROPN
admet-621	36	18	-	-	PUNCT
admet-621	36	19	tec	tec	PROPN
admet-621	36	20	,	,	PUNCT
admet-621	36	21	germany	germany	PROPN
admet-621	36	22	)	)	PUNCT
admet-621	36	23	was	be	AUX
admet-621	36	24	used	use	VERB
admet-621	36	25	to	to	PART
admet-621	36	26	mix	mix	VERB
admet-621	36	27	two	two	NUM
admet-621	36	28	phases	phase	NOUN
admet-621	36	29	and	and	CCONJ
admet-621	36	30	maintain	maintain	VERB
admet-621	36	31	the	the	DET
admet-621	36	32	temperature	temperature	NOUN
admet-621	36	33	of	of	ADP
admet-621	36	34	samples	sample	NOUN
admet-621	36	35	at	at	ADP
admet-621	36	36	37±0.1	37±0.1	NUM
admet-621	36	37	°	°	ADP
admet-621	36	38	c	c	NOUN
admet-621	36	39	during	during	ADP
admet-621	36	40	the	the	DET
admet-621	36	41	solubility	solubility	NOUN
admet-621	36	42	measurements	measurement	NOUN
admet-621	36	43	.	.	PUNCT
admet-621	37	1	samples	sample	NOUN
admet-621	37	2	were	be	AUX
admet-621	37	3	filtered	filter	VERB
admet-621	37	4	using	use	VERB
admet-621	37	5	a	a	DET
admet-621	37	6	hydrophilic	hydrophilic	ADJ
admet-621	37	7	membrane	membrane	NOUN
admet-621	37	8	(	(	PUNCT
admet-621	37	9	450	450	NUM
admet-621	37	10	nm	nm	PRON
admet-621	37	11	pore	pore	ADJ
admet-621	37	12	size	size	NOUN
admet-621	37	13	)	)	PUNCT
admet-621	37	14	.	.	PUNCT
admet-621	38	1	the	the	DET
admet-621	38	2	concentration	concentration	NOUN
admet-621	38	3	of	of	ADP
admet-621	38	4	the	the	DET
admet-621	38	5	saturated	saturate	VERB
admet-621	38	6	solution	solution	NOUN
admet-621	38	7	was	be	AUX
admet-621	38	8	measured	measure	VERB
admet-621	38	9	using	use	VERB
admet-621	38	10	a	a	DET
admet-621	38	11	uv	uv	NOUN
admet-621	38	12	–	–	PUNCT
admet-621	38	13	vis	vis	X
admet-621	38	14	spectrophotometer	spectrophotometer	X
admet-621	38	15	(	(	PUNCT
admet-621	38	16	shimadzu	shimadzu	PROPN
admet-621	38	17	,	,	PUNCT
admet-621	38	18	admet	admet	PROPN
admet-621	38	19	&	&	CCONJ
admet-621	38	20	dmpk	dmpk	PROPN
admet-621	38	21	6(4	6(4	PROPN
admet-621	38	22	)	)	PUNCT
admet-621	38	23	(	(	PUNCT
admet-621	38	24	2018	2018	NUM
admet-621	38	25	)	)	PUNCT
admet-621	38	26	269	269	NUM
admet-621	38	27	-	-	SYM
admet-621	38	28	278	278	NUM
admet-621	38	29	solubility	solubility	NOUN
admet-621	38	30	of	of	ADP
admet-621	38	31	sodium	sodium	NOUN
admet-621	38	32	phenytoin	phenytoin	NOUN
admet-621	38	33	and	and	CCONJ
admet-621	38	34	lamotrigine	lamotrigine	ADJ
admet-621	38	35	doi	doi	NOUN
admet-621	38	36	:	:	PUNCT
admet-621	38	37	10.5599	10.5599	NUM
admet-621	38	38	/	/	SYM
admet-621	38	39	admet.621	admet.621	PROPN
admet-621	38	40	271	271	NUM
admet-621	38	41	japan	japan	PROPN
admet-621	38	42	)	)	PUNCT
admet-621	38	43	.	.	PUNCT
admet-621	39	1	the	the	DET
admet-621	39	2	ph	ph	NOUN
admet-621	39	3	of	of	ADP
admet-621	39	4	the	the	DET
admet-621	39	5	solutions	solution	NOUN
admet-621	39	6	was	be	AUX
admet-621	39	7	measured	measure	VERB
admet-621	39	8	by	by	ADP
admet-621	39	9	a	a	DET
admet-621	39	10	ph	ph	ADJ
admet-621	39	11	meter	meter	NOUN
admet-621	39	12	(	(	PUNCT
admet-621	39	13	metrohm	metrohm	PROPN
admet-621	39	14	,	,	PUNCT
admet-621	39	15	switzerland	switzerland	PROPN
admet-621	39	16	)	)	PUNCT
admet-621	39	17	.	.	PUNCT
admet-621	40	1	measurement	measurement	NOUN
admet-621	40	2	of	of	ADP
admet-621	40	3	solubility	solubility	NOUN
admet-621	40	4	and	and	CCONJ
admet-621	40	5	investigation	investigation	NOUN
admet-621	40	6	of	of	ADP
admet-621	40	7	the	the	DET
admet-621	40	8	effect	effect	NOUN
admet-621	40	9	of	of	ADP
admet-621	40	10	excess	excess	ADJ
admet-621	40	11	amount	amount	NOUN
admet-621	40	12	of	of	ADP
admet-621	40	13	solute	solute	NOUN
admet-621	40	14	and	and	CCONJ
admet-621	40	15	type	type	NOUN
admet-621	40	16	of	of	ADP
admet-621	40	17	stirring	stir	VERB
admet-621	40	18	on	on	ADP
admet-621	40	19	solubility	solubility	NOUN
admet-621	40	20	excess	excess	ADJ
admet-621	40	21	amount	amount	NOUN
admet-621	40	22	of	of	ADP
admet-621	40	23	each	each	DET
admet-621	40	24	drug	drug	NOUN
admet-621	40	25	was	be	AUX
admet-621	40	26	added	add	VERB
admet-621	40	27	to	to	ADP
admet-621	40	28	a	a	DET
admet-621	40	29	small	small	ADJ
admet-621	40	30	volume	volume	NOUN
admet-621	40	31	(	(	PUNCT
admet-621	40	32	e.g.	e.g.	ADV
admet-621	40	33	5	5	NUM
admet-621	40	34	ml	ml	NOUN
admet-621	40	35	)	)	PUNCT
admet-621	40	36	of	of	ADP
admet-621	40	37	the	the	DET
admet-621	40	38	studied	study	VERB
admet-621	40	39	solvent	solvent	NOUN
admet-621	40	40	in	in	ADP
admet-621	40	41	an	an	DET
admet-621	40	42	erlenmeyer	erlenmeyer	PROPN
admet-621	40	43	flask	flask	NOUN
admet-621	40	44	.	.	PUNCT
admet-621	41	1	the	the	DET
admet-621	41	2	amount	amount	NOUN
admet-621	41	3	of	of	ADP
admet-621	41	4	excess	excess	NOUN
admet-621	41	5	was	be	AUX
admet-621	41	6	added	add	VERB
admet-621	41	7	according	accord	VERB
admet-621	41	8	to	to	ADP
admet-621	41	9	the	the	DET
admet-621	41	10	preliminary	preliminary	ADJ
admet-621	41	11	experiments	experiment	NOUN
admet-621	41	12	or	or	CCONJ
admet-621	41	13	reported	report	VERB
admet-621	41	14	solubility	solubility	NOUN
admet-621	41	15	of	of	ADP
admet-621	41	16	drugs	drug	NOUN
admet-621	41	17	in	in	ADP
admet-621	41	18	the	the	DET
admet-621	41	19	studied	study	VERB
admet-621	41	20	solvent	solvent	NOUN
admet-621	41	21	from	from	ADP
admet-621	41	22	the	the	DET
admet-621	41	23	literature	literature	NOUN
admet-621	41	24	(	(	PUNCT
admet-621	41	25	solubility	solubility	NOUN
admet-621	41	26	of	of	ADP
admet-621	41	27	phenytoin	phenytoin	NOUN
admet-621	41	28	in	in	ADP
admet-621	41	29	water	water	NOUN
admet-621	41	30	and	and	CCONJ
admet-621	41	31	ethanol	ethanol	NOUN
admet-621	41	32	are	be	AUX
admet-621	41	33	86	86	NUM
admet-621	41	34	mg	mg	NUM
admet-621	41	35	/	/	SYM
admet-621	41	36	ml	ml	PROPN
admet-621	41	37	and	and	CCONJ
admet-621	41	38	19.9	19.9	NUM
admet-621	41	39	mg	mg	NOUN
admet-621	41	40	/	/	SYM
admet-621	41	41	ml	ml	NOUN
admet-621	41	42	at	at	ADP
admet-621	41	43	35	35	NUM
admet-621	41	44	°	°	NOUN
admet-621	41	45	c	c	NOUN
admet-621	41	46	[	[	X
admet-621	41	47	17	17	NUM
admet-621	41	48	]	]	PUNCT
admet-621	41	49	,	,	PUNCT
admet-621	41	50	respectively	respectively	ADV
admet-621	41	51	and	and	CCONJ
admet-621	41	52	lamotrigine	lamotrigine	NOUN
admet-621	41	53	solubility	solubility	NOUN
admet-621	41	54	in	in	ADP
admet-621	41	55	water	water	NOUN
admet-621	41	56	and	and	CCONJ
admet-621	41	57	hcl	hcl	PROPN
admet-621	41	58	0.1	0.1	NUM
admet-621	41	59	m	m	NOUN
admet-621	41	60	are	be	AUX
admet-621	41	61	0.19	0.19	NUM
admet-621	41	62	mg	mg	NUM
admet-621	41	63	/	/	SYM
admet-621	41	64	ml	ml	NOUN
admet-621	42	1	[	[	X
admet-621	42	2	18	18	NUM
admet-621	42	3	]	]	PUNCT
admet-621	42	4	and	and	CCONJ
admet-621	42	5	2.22	2.22	NUM
admet-621	42	6	mg	mg	NUM
admet-621	42	7	/	/	SYM
admet-621	42	8	ml	ml	NOUN
admet-621	43	1	[	[	X
admet-621	43	2	19	19	NUM
admet-621	43	3	]	]	X
admet-621	43	4	at	at	ADP
admet-621	43	5	25	25	NUM
admet-621	43	6	°	°	NOUN
admet-621	43	7	c	c	NOUN
admet-621	43	8	,	,	PUNCT
admet-621	43	9	respectively	respectively	ADV
admet-621	43	10	)	)	PUNCT
admet-621	43	11	.	.	PUNCT
admet-621	44	1	therefore	therefore	ADV
admet-621	44	2	,	,	PUNCT
admet-621	44	3	in	in	ADP
admet-621	44	4	this	this	DET
admet-621	44	5	study	study	NOUN
admet-621	44	6	,	,	PUNCT
admet-621	44	7	the	the	DET
admet-621	44	8	volume	volume	NOUN
admet-621	44	9	of	of	ADP
admet-621	44	10	solvent	solvent	NOUN
admet-621	44	11	was	be	AUX
admet-621	44	12	considered	consider	VERB
admet-621	44	13	5	5	NUM
admet-621	44	14	ml	ml	NOUN
admet-621	44	15	in	in	ADP
admet-621	44	16	an	an	DET
admet-621	44	17	erlenmeyer	erlenmeyer	PROPN
admet-621	44	18	flask	flask	NOUN
admet-621	44	19	,	,	PUNCT
admet-621	44	20	being	be	AUX
admet-621	44	21	similar	similar	ADJ
admet-621	44	22	to	to	ADP
admet-621	44	23	the	the	DET
admet-621	44	24	routine	routine	ADJ
admet-621	44	25	experiment	experiment	NOUN
admet-621	44	26	of	of	ADP
admet-621	44	27	solubility	solubility	NOUN
admet-621	44	28	determination	determination	NOUN
admet-621	44	29	in	in	ADP
admet-621	44	30	the	the	DET
admet-621	44	31	pharmaceutical	pharmaceutical	ADJ
admet-621	44	32	and	and	CCONJ
admet-621	44	33	chemical	chemical	NOUN
admet-621	44	34	laboratories	laboratory	NOUN
admet-621	44	35	.	.	PUNCT
admet-621	45	1	for	for	ADP
admet-621	45	2	highly	highly	ADV
admet-621	45	3	soluble	soluble	ADJ
admet-621	45	4	compounds	compound	NOUN
admet-621	45	5	,	,	PUNCT
admet-621	45	6	e.g.	e.g.	ADV
admet-621	45	7	sodium	sodium	NOUN
admet-621	45	8	phenytoin	phenytoin	NOUN
admet-621	45	9	in	in	ADP
admet-621	45	10	water	water	NOUN
admet-621	45	11	10	10	NUM
admet-621	45	12	%	%	NOUN
admet-621	45	13	,	,	PUNCT
admet-621	45	14	25	25	NUM
admet-621	45	15	%	%	NOUN
admet-621	45	16	,	,	PUNCT
admet-621	45	17	100	100	NUM
admet-621	45	18	%	%	NOUN
admet-621	45	19	,	,	PUNCT
admet-621	45	20	150	150	NUM
admet-621	45	21	%	%	NOUN
admet-621	45	22	and	and	CCONJ
admet-621	45	23	200	200	NUM
admet-621	45	24	%	%	NOUN
admet-621	45	25	of	of	ADP
admet-621	45	26	saturated	saturate	VERB
admet-621	45	27	solubility	solubility	NOUN
admet-621	45	28	of	of	ADP
admet-621	45	29	the	the	DET
admet-621	45	30	drug	drug	NOUN
admet-621	45	31	was	be	AUX
admet-621	45	32	applied	apply	VERB
admet-621	45	33	as	as	ADP
admet-621	45	34	an	an	DET
admet-621	45	35	excess	excess	ADJ
admet-621	45	36	solid	solid	ADJ
admet-621	45	37	amount	amount	NOUN
admet-621	45	38	.	.	PUNCT
admet-621	46	1	while	while	SCONJ
admet-621	46	2	for	for	ADP
admet-621	46	3	low	low	ADJ
admet-621	46	4	solubility	solubility	NOUN
admet-621	46	5	values	value	NOUN
admet-621	46	6	,	,	PUNCT
admet-621	46	7	e.g.	e.g.	ADV
admet-621	46	8	lamotrigine	lamotrigine	NOUN
admet-621	46	9	in	in	ADP
admet-621	46	10	water	water	NOUN
admet-621	46	11	,	,	PUNCT
admet-621	46	12	the	the	DET
admet-621	46	13	minimum	minimum	NOUN
admet-621	46	14	amount	amount	NOUN
admet-621	46	15	of	of	ADP
admet-621	46	16	drug	drug	NOUN
admet-621	46	17	could	could	AUX
admet-621	46	18	be	be	AUX
admet-621	46	19	weighted	weight	VERB
admet-621	46	20	by	by	ADP
admet-621	46	21	a	a	DET
admet-621	46	22	digital	digital	ADJ
admet-621	46	23	balance	balance	NOUN
admet-621	46	24	(	(	PUNCT
admet-621	46	25	the	the	DET
admet-621	46	26	minimum	minimum	NOUN
admet-621	46	27	amount	amount	NOUN
admet-621	46	28	of	of	ADP
admet-621	46	29	weighting	weight	VERB
admet-621	46	30	10	10	NUM
admet-621	46	31	-	-	SYM
admet-621	46	32	30	30	NUM
admet-621	46	33	mg	mg	NUM
admet-621	46	34	)	)	PUNCT
admet-621	46	35	,	,	PUNCT
admet-621	46	36	was	be	AUX
admet-621	46	37	selected	select	VERB
admet-621	46	38	as	as	ADP
admet-621	46	39	the	the	DET
admet-621	46	40	lowest	low	ADJ
admet-621	46	41	concentration	concentration	NOUN
admet-621	46	42	of	of	ADP
admet-621	46	43	suspension	suspension	NOUN
admet-621	46	44	for	for	ADP
admet-621	46	45	solubility	solubility	NOUN
admet-621	46	46	determination	determination	NOUN
admet-621	46	47	and	and	CCONJ
admet-621	46	48	other	other	ADJ
admet-621	46	49	solutions	solution	NOUN
admet-621	46	50	up	up	ADP
admet-621	46	51	to	to	PART
admet-621	46	52	5	5	NUM
admet-621	46	53	-	-	PUNCT
admet-621	46	54	folds	fold	NOUN
admet-621	46	55	of	of	ADP
admet-621	46	56	this	this	DET
admet-621	46	57	amount	amount	NOUN
admet-621	46	58	were	be	AUX
admet-621	46	59	prepared	prepare	VERB
admet-621	46	60	to	to	PART
admet-621	46	61	simulate	simulate	VERB
admet-621	46	62	a	a	DET
admet-621	46	63	routine	routine	ADJ
admet-621	46	64	solubility	solubility	NOUN
admet-621	46	65	determination	determination	NOUN
admet-621	46	66	experiment	experiment	NOUN
admet-621	46	67	.	.	PUNCT
admet-621	47	1	then	then	ADV
admet-621	47	2	,	,	PUNCT
admet-621	47	3	the	the	DET
admet-621	47	4	samples	sample	NOUN
admet-621	47	5	were	be	AUX
admet-621	47	6	placed	place	VERB
admet-621	47	7	in	in	ADP
admet-621	47	8	an	an	DET
admet-621	47	9	incubator	incubator	NOUN
admet-621	47	10	equipped	equip	VERB
admet-621	47	11	with	with	ADP
admet-621	47	12	a	a	DET
admet-621	47	13	temperature	temperature	NOUN
admet-621	47	14	-	-	PUNCT
admet-621	47	15	controlling	control	VERB
admet-621	47	16	system	system	NOUN
admet-621	47	17	at	at	ADP
admet-621	47	18	37	37	NUM
admet-621	47	19	°	°	NOUN
admet-621	47	20	c	c	NOUN
admet-621	47	21	in	in	ADP
admet-621	47	22	150	150	NUM
admet-621	47	23	rpm	rpm	NOUN
admet-621	47	24	for	for	ADP
admet-621	47	25	48	48	NUM
admet-621	47	26	hours	hour	NOUN
admet-621	47	27	.	.	PUNCT
admet-621	48	1	afterward	afterward	ADV
admet-621	48	2	,	,	PUNCT
admet-621	48	3	the	the	DET
admet-621	48	4	saturated	saturate	VERB
admet-621	48	5	solutions	solution	NOUN
admet-621	48	6	of	of	ADP
admet-621	48	7	the	the	DET
admet-621	48	8	drugs	drug	NOUN
admet-621	48	9	were	be	AUX
admet-621	48	10	filtered	filter	VERB
admet-621	48	11	using	use	VERB
admet-621	48	12	hydrophilic	hydrophilic	ADJ
admet-621	48	13	filters	filter	NOUN
admet-621	48	14	(	(	PUNCT
admet-621	48	15	0.45	0.45	NUM
admet-621	48	16	µm	µm	NOUN
admet-621	48	17	)	)	PUNCT
admet-621	48	18	.	.	PUNCT
admet-621	49	1	in	in	ADP
admet-621	49	2	addition	addition	NOUN
admet-621	49	3	,	,	PUNCT
admet-621	49	4	magnetic	magnetic	ADJ
admet-621	49	5	stirrer	stirrer	NOUN
admet-621	49	6	and	and	CCONJ
admet-621	49	7	shake	shake	NOUN
admet-621	49	8	-	-	PUNCT
admet-621	49	9	flask	flask	NOUN
admet-621	49	10	approaches	approach	NOUN
admet-621	49	11	,	,	PUNCT
admet-621	49	12	separately	separately	ADV
admet-621	49	13	,	,	PUNCT
admet-621	49	14	were	be	AUX
admet-621	49	15	used	use	VERB
admet-621	49	16	to	to	PART
admet-621	49	17	saturate	saturate	VERB
admet-621	49	18	sodium	sodium	NOUN
admet-621	49	19	phenytoin	phenytoin	NOUN
admet-621	49	20	and	and	CCONJ
admet-621	49	21	lamotrigine	lamotrigine	NOUN
admet-621	49	22	in	in	ADP
admet-621	49	23	water	water	NOUN
admet-621	49	24	at	at	ADP
admet-621	49	25	37	37	NUM
admet-621	49	26	°	°	ADP
admet-621	49	27	c	c	NOUN
admet-621	49	28	and	and	CCONJ
admet-621	49	29	150	150	NUM
admet-621	49	30	rpm	rpm	NOUN
admet-621	49	31	for	for	ADP
admet-621	49	32	48	48	NUM
admet-621	49	33	hours	hour	NOUN
admet-621	49	34	.	.	PUNCT
admet-621	50	1	furthermore	furthermore	ADV
admet-621	50	2	,	,	PUNCT
admet-621	50	3	the	the	DET
admet-621	50	4	concentration	concentration	NOUN
admet-621	50	5	of	of	ADP
admet-621	50	6	samples	sample	NOUN
admet-621	50	7	was	be	AUX
admet-621	50	8	measured	measure	VERB
admet-621	50	9	after	after	ADP
admet-621	50	10	24	24	NUM
admet-621	50	11	-	-	PUNCT
admet-621	50	12	hour	hour	NOUN
admet-621	50	13	sedimentation	sedimentation	NOUN
admet-621	50	14	.	.	PUNCT
admet-621	51	1	the	the	DET
admet-621	51	2	concentration	concentration	NOUN
admet-621	51	3	of	of	ADP
admet-621	51	4	samples	sample	NOUN
admet-621	51	5	was	be	AUX
admet-621	51	6	measured	measure	VERB
admet-621	51	7	by	by	ADP
admet-621	51	8	a	a	DET
admet-621	51	9	uv	uv	NOUN
admet-621	51	10	spectrophotometer	spectrophotometer	NOUN
admet-621	51	11	.	.	PUNCT
admet-621	52	1	each	each	DET
admet-621	52	2	datum	datum	NOUN
admet-621	52	3	was	be	AUX
admet-621	52	4	obtained	obtain	VERB
admet-621	52	5	from	from	ADP
admet-621	52	6	at	at	ADV
admet-621	52	7	least	least	ADV
admet-621	52	8	three	three	NUM
admet-621	52	9	replicate	replicate	ADJ
admet-621	52	10	independent	independent	ADJ
admet-621	52	11	measurements	measurement	NOUN
admet-621	52	12	,	,	PUNCT
admet-621	52	13	and	and	CCONJ
admet-621	52	14	the	the	DET
admet-621	52	15	maximum	maximum	ADJ
admet-621	52	16	relative	relative	ADJ
admet-621	52	17	standard	standard	ADJ
admet-621	52	18	deviation	deviation	NOUN
admet-621	52	19	(	(	PUNCT
admet-621	52	20	rsd	rsd	NOUN
admet-621	52	21	)	)	PUNCT
admet-621	52	22	of	of	ADP
admet-621	52	23	each	each	DET
admet-621	52	24	experiment	experiment	NOUN
admet-621	52	25	was	be	AUX
admet-621	52	26	10	10	NUM
admet-621	52	27	%	%	NOUN
admet-621	52	28	.	.	PUNCT
admet-621	53	1	results	result	VERB
admet-621	53	2	the	the	DET
admet-621	53	3	effect	effect	NOUN
admet-621	53	4	of	of	ADP
admet-621	53	5	the	the	DET
admet-621	53	6	excess	excess	ADJ
admet-621	53	7	solid	solid	ADJ
admet-621	53	8	amount	amount	NOUN
admet-621	53	9	on	on	ADP
admet-621	53	10	solubility	solubility	NOUN
admet-621	53	11	of	of	ADP
admet-621	53	12	sodium	sodium	NOUN
admet-621	53	13	phenytoin	phenytoin	NOUN
admet-621	53	14	in	in	ADP
admet-621	53	15	water	water	NOUN
admet-621	53	16	,	,	PUNCT
admet-621	53	17	ethanol	ethanol	NOUN
admet-621	53	18	and	and	CCONJ
admet-621	53	19	hcl	hcl	PROPN
admet-621	53	20	(	(	PUNCT
admet-621	53	21	0.1	0.1	NUM
admet-621	53	22	m	m	NOUN
admet-621	53	23	)	)	PUNCT
admet-621	53	24	figure	figure	NOUN
admet-621	53	25	1	1	NUM
admet-621	53	26	shows	show	VERB
admet-621	53	27	the	the	DET
admet-621	53	28	solubility	solubility	NOUN
admet-621	53	29	of	of	ADP
admet-621	53	30	sodium	sodium	NOUN
admet-621	53	31	phenytoin	phenytoin	NOUN
admet-621	53	32	in	in	ADP
admet-621	53	33	water	water	NOUN
admet-621	53	34	at	at	ADP
admet-621	53	35	37	37	NUM
admet-621	53	36	°	°	NOUN
admet-621	53	37	c	c	NOUN
admet-621	53	38	.	.	PUNCT
admet-621	54	1	the	the	DET
admet-621	54	2	experiment	experiment	NOUN
admet-621	54	3	was	be	AUX
admet-621	54	4	investigated	investigate	VERB
admet-621	54	5	in	in	ADP
admet-621	54	6	various	various	ADJ
admet-621	54	7	excess	excess	ADJ
admet-621	54	8	amounts	amount	NOUN
admet-621	54	9	of	of	ADP
admet-621	54	10	phenytoin	phenytoin	ADJ
admet-621	54	11	sodium	sodium	NOUN
admet-621	54	12	.	.	PUNCT
admet-621	55	1	a	a	DET
admet-621	55	2	linear	linear	ADJ
admet-621	55	3	relationship	relationship	NOUN
admet-621	55	4	exists	exist	VERB
admet-621	55	5	between	between	ADP
admet-621	55	6	excess	excess	ADJ
admet-621	55	7	solid	solid	ADJ
admet-621	55	8	amount	amount	NOUN
admet-621	55	9	of	of	ADP
admet-621	55	10	drug	drug	NOUN
admet-621	55	11	and	and	CCONJ
admet-621	55	12	solubility	solubility	NOUN
admet-621	55	13	.	.	PUNCT
admet-621	56	1	the	the	DET
admet-621	56	2	percentage	percentage	NOUN
admet-621	56	3	change	change	NOUN
admet-621	56	4	between	between	ADP
admet-621	56	5	the	the	DET
admet-621	56	6	maximum	maximum	ADJ
admet-621	56	7	and	and	CCONJ
admet-621	56	8	minimum	minimum	ADJ
admet-621	56	9	values	value	NOUN
admet-621	56	10	of	of	ADP
admet-621	56	11	solubility	solubility	NOUN
admet-621	56	12	is	be	AUX
admet-621	56	13	116	116	NUM
admet-621	56	14	%	%	NOUN
admet-621	56	15	;	;	PUNCT
admet-621	56	16	however	however	ADV
admet-621	56	17	,	,	PUNCT
admet-621	56	18	the	the	DET
admet-621	56	19	excess	excess	ADJ
admet-621	56	20	amount	amount	NOUN
admet-621	56	21	has	have	VERB
admet-621	56	22	a	a	DET
admet-621	56	23	low	low	ADJ
admet-621	56	24	effect	effect	NOUN
admet-621	56	25	on	on	ADP
admet-621	56	26	solubility	solubility	NOUN
admet-621	56	27	of	of	ADP
admet-621	56	28	phenytoin	phenytoin	NOUN
admet-621	56	29	in	in	ADP
admet-621	56	30	hcl	hcl	PROPN
admet-621	56	31	0.1	0.1	NUM
admet-621	56	32	m	m	PROPN
admet-621	56	33	(	(	PUNCT
admet-621	56	34	figure	figure	NOUN
admet-621	56	35	2	2	NUM
admet-621	56	36	)	)	PUNCT
admet-621	56	37	in	in	ADP
admet-621	56	38	comparison	comparison	NOUN
admet-621	56	39	to	to	ADP
admet-621	56	40	solubility	solubility	NOUN
admet-621	56	41	in	in	ADP
admet-621	56	42	water	water	NOUN
admet-621	56	43	(	(	PUNCT
admet-621	56	44	percentage	percentage	NOUN
admet-621	56	45	change	change	NOUN
admet-621	56	46	was	be	AUX
admet-621	56	47	less	less	ADJ
admet-621	56	48	than	than	ADP
admet-621	56	49	30	30	NUM
admet-621	56	50	%	%	NOUN
admet-621	56	51	)	)	PUNCT
admet-621	56	52	.	.	PUNCT
admet-621	57	1	moreover	moreover	ADV
admet-621	57	2	,	,	PUNCT
admet-621	57	3	to	to	PART
admet-621	57	4	confirm	confirm	VERB
admet-621	57	5	the	the	DET
admet-621	57	6	effect	effect	NOUN
admet-621	57	7	of	of	ADP
admet-621	57	8	excess	excess	ADJ
admet-621	57	9	amount	amount	NOUN
admet-621	57	10	in	in	ADP
admet-621	57	11	ionized	ionized	ADJ
admet-621	57	12	form	form	NOUN
admet-621	57	13	,	,	PUNCT
admet-621	57	14	phenytoin	phenytoin	ADJ
admet-621	57	15	solubility	solubility	NOUN
admet-621	57	16	was	be	AUX
admet-621	57	17	performed	perform	VERB
admet-621	57	18	in	in	ADP
admet-621	57	19	ethanol	ethanol	NOUN
admet-621	57	20	(	(	PUNCT
admet-621	57	21	dielectric	dielectric	ADJ
admet-621	57	22	constant	constant	ADJ
admet-621	57	23	of	of	ADP
admet-621	57	24	ethanol	ethanol	NOUN
admet-621	57	25	is	be	AUX
admet-621	57	26	lower	low	ADJ
admet-621	57	27	than	than	ADP
admet-621	57	28	water	water	NOUN
admet-621	57	29	and	and	CCONJ
admet-621	57	30	the	the	DET
admet-621	57	31	ionization	ionization	NOUN
admet-621	57	32	in	in	ADP
admet-621	57	33	ethanol	ethanol	NOUN
admet-621	57	34	is	be	AUX
admet-621	57	35	less	less	ADJ
admet-621	57	36	than	than	ADP
admet-621	57	37	water	water	NOUN
admet-621	57	38	)	)	PUNCT
admet-621	57	39	and	and	CCONJ
admet-621	57	40	the	the	DET
admet-621	57	41	results	result	NOUN
admet-621	57	42	were	be	AUX
admet-621	57	43	illustrated	illustrate	VERB
admet-621	57	44	in	in	ADP
admet-621	57	45	figure	figure	NOUN
admet-621	57	46	3	3	NUM
admet-621	57	47	.	.	PUNCT
admet-621	58	1	a	a	DET
admet-621	58	2	similar	similar	ADJ
admet-621	58	3	pattern	pattern	NOUN
admet-621	58	4	to	to	ADP
admet-621	58	5	hcl	hcl	PROPN
admet-621	58	6	(	(	PUNCT
admet-621	58	7	percentage	percentage	NOUN
admet-621	58	8	difference	difference	NOUN
admet-621	58	9	was	be	AUX
admet-621	58	10	21	21	NUM
admet-621	58	11	%	%	NOUN
admet-621	58	12	)	)	PUNCT
admet-621	58	13	was	be	AUX
admet-621	58	14	obtained	obtain	VERB
admet-621	58	15	for	for	ADP
admet-621	58	16	solubility	solubility	NOUN
admet-621	58	17	of	of	ADP
admet-621	58	18	sodium	sodium	NOUN
admet-621	58	19	phenytoin	phenytoin	NOUN
admet-621	58	20	in	in	ADP
admet-621	58	21	ethanol	ethanol	NOUN
admet-621	58	22	.	.	PUNCT
admet-621	59	1	the	the	DET
admet-621	59	2	effect	effect	NOUN
admet-621	59	3	of	of	ADP
admet-621	59	4	the	the	DET
admet-621	59	5	excess	excess	ADJ
admet-621	59	6	solid	solid	ADJ
admet-621	59	7	amount	amount	NOUN
admet-621	59	8	on	on	ADP
admet-621	59	9	solubility	solubility	NOUN
admet-621	59	10	of	of	ADP
admet-621	59	11	lamotrigine	lamotrigine	NOUN
admet-621	59	12	in	in	ADP
admet-621	59	13	water	water	NOUN
admet-621	59	14	,	,	PUNCT
admet-621	59	15	ethanol	ethanol	NOUN
admet-621	59	16	and	and	CCONJ
admet-621	59	17	hcl	hcl	PROPN
admet-621	59	18	(	(	PUNCT
admet-621	59	19	0.1	0.1	NUM
admet-621	59	20	m	m	NOUN
admet-621	59	21	)	)	PUNCT
admet-621	59	22	figure	figure	VERB
admet-621	59	23	4	4	NUM
admet-621	59	24	illustrates	illustrate	VERB
admet-621	59	25	solubility	solubility	NOUN
admet-621	59	26	of	of	ADP
admet-621	59	27	lamotrigine	lamotrigine	NOUN
admet-621	59	28	in	in	ADP
admet-621	59	29	water	water	NOUN
admet-621	59	30	at	at	ADP
admet-621	59	31	37	37	NUM
admet-621	59	32	°	°	NOUN
admet-621	59	33	c	c	NOUN
admet-621	59	34	in	in	ADP
admet-621	59	35	different	different	ADJ
admet-621	59	36	amounts	amount	NOUN
admet-621	59	37	of	of	ADP
admet-621	59	38	excess	excess	NOUN
admet-621	59	39	solid	solid	ADJ
admet-621	59	40	,	,	PUNCT
admet-621	59	41	and	and	CCONJ
admet-621	59	42	the	the	DET
admet-621	59	43	obtained	obtain	VERB
admet-621	59	44	data	datum	NOUN
admet-621	59	45	revealed	reveal	VERB
admet-621	59	46	that	that	SCONJ
admet-621	59	47	excess	excess	ADJ
admet-621	59	48	amount	amount	NOUN
admet-621	59	49	had	have	VERB
admet-621	59	50	no	no	DET
admet-621	59	51	significant	significant	ADJ
admet-621	59	52	effect	effect	NOUN
admet-621	59	53	on	on	ADP
admet-621	59	54	solubility	solubility	NOUN
admet-621	59	55	value	value	NOUN
admet-621	59	56	.	.	PUNCT
admet-621	60	1	however	however	ADV
admet-621	60	2	,	,	PUNCT
admet-621	60	3	it	it	PRON
admet-621	60	4	has	have	VERB
admet-621	60	5	a	a	DET
admet-621	60	6	considerable	considerable	ADJ
admet-621	60	7	effect	effect	NOUN
admet-621	60	8	on	on	ADP
admet-621	60	9	solubility	solubility	NOUN
admet-621	60	10	value	value	NOUN
admet-621	60	11	in	in	ADP
admet-621	60	12	hcl	hcl	PROPN
admet-621	60	13	0.1	0.1	NUM
admet-621	60	14	m	m	PROPN
admet-621	60	15	(	(	PUNCT
admet-621	60	16	figure	figure	NOUN
admet-621	60	17	5	5	NUM
admet-621	60	18	,	,	PUNCT
admet-621	60	19	the	the	DET
admet-621	60	20	percentage	percentage	NOUN
admet-621	60	21	difference	difference	NOUN
admet-621	60	22	between	between	ADP
admet-621	60	23	the	the	DET
admet-621	60	24	maximum	maximum	ADJ
admet-621	60	25	and	and	CCONJ
admet-621	60	26	minimum	minimum	NOUN
admet-621	60	27	amount	amount	NOUN
admet-621	60	28	of	of	ADP
admet-621	60	29	solubility	solubility	NOUN
admet-621	60	30	value	value	NOUN
admet-621	60	31	was	be	AUX
admet-621	60	32	higher	high	ADJ
admet-621	60	33	than	than	ADP
admet-621	60	34	40	40	NUM
admet-621	60	35	%	%	NOUN
admet-621	60	36	)	)	PUNCT
admet-621	60	37	,	,	PUNCT
admet-621	60	38	which	which	DET
admet-621	60	39	lamotrigine	lamotrigine	NOUN
admet-621	60	40	is	be	AUX
admet-621	60	41	in	in	ADP
admet-621	60	42	an	an	DET
admet-621	60	43	ionized	ionized	ADJ
admet-621	60	44	form	form	NOUN
admet-621	60	45	similar	similar	ADJ
admet-621	60	46	to	to	ADP
admet-621	60	47	the	the	DET
admet-621	60	48	data	datum	NOUN
admet-621	60	49	obtained	obtain	VERB
admet-621	60	50	for	for	ADP
admet-621	60	51	phenytoin	phenytoin	ADJ
admet-621	60	52	sodium	sodium	NOUN
admet-621	60	53	.	.	PUNCT
admet-621	61	1	ali	ali	PROPN
admet-621	61	2	shayanfar	shayanfar	PROPN
admet-621	61	3	et	et	PROPN
admet-621	61	4	al	al	PROPN
admet-621	61	5	.	.	PROPN
admet-621	61	6	admet	admet	PROPN
admet-621	61	7	&	&	CCONJ
admet-621	61	8	dmpk	dmpk	PROPN
admet-621	61	9	6(4	6(4	PROPN
admet-621	61	10	)	)	PUNCT
admet-621	61	11	(	(	PUNCT
admet-621	61	12	2018	2018	NUM
admet-621	61	13	)	)	PUNCT
admet-621	61	14	269	269	NUM
admet-621	61	15	-	-	SYM
admet-621	61	16	278	278	NUM
admet-621	61	17	272	272	NUM
admet-621	61	18	the	the	DET
admet-621	61	19	effect	effect	NOUN
admet-621	61	20	of	of	ADP
admet-621	61	21	type	type	NOUN
admet-621	61	22	of	of	ADP
admet-621	61	23	stirring	stirring	NOUN
admet-621	61	24	and	and	CCONJ
admet-621	61	25	sedimentation	sedimentation	NOUN
admet-621	61	26	time	time	NOUN
admet-621	61	27	on	on	ADP
admet-621	61	28	solubility	solubility	NOUN
admet-621	61	29	of	of	ADP
admet-621	61	30	sodium	sodium	NOUN
admet-621	61	31	phenytoin	phenytoin	NOUN
admet-621	61	32	and	and	CCONJ
admet-621	61	33	lamotrigine	lamotrigine	NOUN
admet-621	61	34	in	in	ADP
admet-621	61	35	water	water	NOUN
admet-621	61	36	magnetic	magnetic	ADJ
admet-621	61	37	stirrer	stirrer	NOUN
admet-621	61	38	and	and	CCONJ
admet-621	61	39	shake	shake	NOUN
admet-621	61	40	-	-	PUNCT
admet-621	61	41	flask	flask	NOUN
admet-621	61	42	approaches	approach	NOUN
admet-621	61	43	were	be	AUX
admet-621	61	44	used	use	VERB
admet-621	61	45	to	to	PART
admet-621	61	46	saturate	saturate	VERB
admet-621	61	47	sodium	sodium	NOUN
admet-621	61	48	phenytoin	phenytoin	NOUN
admet-621	61	49	and	and	CCONJ
admet-621	61	50	lamotrigine	lamotrigine	NOUN
admet-621	61	51	in	in	ADP
admet-621	61	52	water	water	NOUN
admet-621	61	53	at	at	ADP
admet-621	61	54	37	37	NUM
admet-621	61	55	°	°	NOUN
admet-621	61	56	c	c	NOUN
admet-621	61	57	.	.	PUNCT
admet-621	62	1	figure	figure	NOUN
admet-621	62	2	6	6	NUM
admet-621	62	3	illustrates	illustrate	VERB
admet-621	62	4	the	the	DET
admet-621	62	5	effect	effect	NOUN
admet-621	62	6	of	of	ADP
admet-621	62	7	type	type	NOUN
admet-621	62	8	of	of	ADP
admet-621	62	9	stirring	stir	VERB
admet-621	62	10	on	on	ADP
admet-621	62	11	the	the	DET
admet-621	62	12	obtained	obtain	VERB
admet-621	62	13	solubility	solubility	NOUN
admet-621	62	14	value	value	NOUN
admet-621	62	15	,	,	PUNCT
admet-621	62	16	and	and	CCONJ
admet-621	62	17	shown	show	VERB
admet-621	62	18	,	,	PUNCT
admet-621	62	19	the	the	DET
admet-621	62	20	type	type	NOUN
admet-621	62	21	of	of	ADP
admet-621	62	22	stirring	stirring	NOUN
admet-621	62	23	for	for	ADP
admet-621	62	24	solubility	solubility	NOUN
admet-621	62	25	determination	determination	NOUN
admet-621	62	26	has	have	VERB
admet-621	62	27	no	no	DET
admet-621	62	28	significant	significant	ADJ
admet-621	62	29	effect	effect	NOUN
admet-621	62	30	on	on	ADP
admet-621	62	31	the	the	DET
admet-621	62	32	saturated	saturate	VERB
admet-621	62	33	concentration	concentration	NOUN
admet-621	62	34	(	(	PUNCT
admet-621	62	35	solubility	solubility	NOUN
admet-621	62	36	)	)	PUNCT
admet-621	62	37	of	of	ADP
admet-621	62	38	phenytoin	phenytoin	ADJ
admet-621	62	39	sodium	sodium	NOUN
admet-621	62	40	.	.	PUNCT
admet-621	63	1	moreover	moreover	ADV
admet-621	63	2	,	,	PUNCT
admet-621	63	3	sedimentation	sedimentation	NOUN
admet-621	63	4	time	time	NOUN
admet-621	63	5	after	after	SCONJ
admet-621	63	6	24	24	NUM
admet-621	63	7	-	-	PUNCT
admet-621	63	8	hour	hour	NOUN
admet-621	63	9	(	(	PUNCT
admet-621	63	10	figures	figure	NOUN
admet-621	63	11	7	7	NUM
admet-621	63	12	and	and	CCONJ
admet-621	63	13	8)	8)	NUM
admet-621	63	14	was	be	AUX
admet-621	63	15	investigated	investigate	VERB
admet-621	63	16	on	on	ADP
admet-621	63	17	the	the	DET
admet-621	63	18	solubility	solubility	NOUN
admet-621	63	19	values	value	NOUN
admet-621	63	20	,	,	PUNCT
admet-621	63	21	and	and	CCONJ
admet-621	63	22	a	a	DET
admet-621	63	23	significant	significant	ADJ
admet-621	63	24	change	change	NOUN
admet-621	63	25	was	be	AUX
admet-621	63	26	observed	observe	VERB
admet-621	63	27	in	in	ADP
admet-621	63	28	solubility	solubility	NOUN
admet-621	63	29	of	of	ADP
admet-621	63	30	sodium	sodium	NOUN
admet-621	63	31	phenytoin	phenytoin	NOUN
admet-621	63	32	in	in	ADP
admet-621	63	33	both	both	DET
admet-621	63	34	stirring	stir	VERB
admet-621	63	35	instruments	instrument	NOUN
admet-621	63	36	.	.	PUNCT
admet-621	64	1	similar	similar	ADJ
admet-621	64	2	results	result	NOUN
admet-621	64	3	were	be	AUX
admet-621	64	4	observed	observe	VERB
admet-621	64	5	for	for	ADP
admet-621	64	6	solubility	solubility	NOUN
admet-621	64	7	determination	determination	NOUN
admet-621	64	8	of	of	ADP
admet-621	64	9	lamotrigine	lamotrigine	NOUN
admet-621	64	10	in	in	ADP
admet-621	64	11	water	water	NOUN
admet-621	64	12	(	(	PUNCT
admet-621	64	13	figure	figure	NOUN
admet-621	64	14	9	9	NUM
admet-621	64	15	)	)	PUNCT
admet-621	64	16	.	.	PUNCT
admet-621	65	1	the	the	DET
admet-621	65	2	data	datum	NOUN
admet-621	65	3	indicate	indicate	VERB
admet-621	65	4	that	that	SCONJ
admet-621	65	5	sedimentation	sedimentation	NOUN
admet-621	65	6	time	time	NOUN
admet-621	65	7	seems	seem	VERB
admet-621	65	8	to	to	PART
admet-621	65	9	have	have	VERB
admet-621	65	10	a	a	DET
admet-621	65	11	significant	significant	ADJ
admet-621	65	12	effect	effect	NOUN
admet-621	65	13	on	on	ADP
admet-621	65	14	solubility	solubility	NOUN
admet-621	65	15	value	value	NOUN
admet-621	65	16	,	,	PUNCT
admet-621	65	17	particularly	particularly	ADV
admet-621	65	18	for	for	ADP
admet-621	65	19	stirring	stirring	NOUN
admet-621	65	20	of	of	ADP
admet-621	65	21	the	the	DET
admet-621	65	22	solution	solution	NOUN
admet-621	65	23	with	with	ADP
admet-621	65	24	magnet	magnet	NOUN
admet-621	65	25	stirrer	stirrer	NOUN
admet-621	65	26	.	.	PUNCT
admet-621	66	1	discussion	discussion	VERB
admet-621	66	2	the	the	DET
admet-621	66	3	effect	effect	NOUN
admet-621	66	4	of	of	ADP
admet-621	66	5	excess	excess	ADJ
admet-621	66	6	amount	amount	NOUN
admet-621	66	7	on	on	ADP
admet-621	66	8	solubility	solubility	NOUN
admet-621	66	9	of	of	ADP
admet-621	66	10	sodium	sodium	NOUN
admet-621	66	11	phenytoin	phenytoin	NOUN
admet-621	66	12	and	and	CCONJ
admet-621	66	13	lamotrigine	lamotrigine	NOUN
admet-621	66	14	the	the	DET
admet-621	66	15	study	study	NOUN
admet-621	66	16	results	result	NOUN
admet-621	66	17	show	show	VERB
admet-621	66	18	that	that	SCONJ
admet-621	66	19	excess	excess	ADJ
admet-621	66	20	solid	solid	ADJ
admet-621	66	21	amount	amount	NOUN
admet-621	66	22	of	of	ADP
admet-621	66	23	the	the	DET
admet-621	66	24	studied	study	VERB
admet-621	66	25	drugs	drug	NOUN
admet-621	66	26	has	have	VERB
admet-621	66	27	a	a	DET
admet-621	66	28	considerable	considerable	ADJ
admet-621	66	29	effect	effect	NOUN
admet-621	66	30	on	on	ADP
admet-621	66	31	solubility	solubility	NOUN
admet-621	66	32	,	,	PUNCT
admet-621	66	33	especially	especially	ADV
admet-621	66	34	in	in	ADP
admet-621	66	35	ionized	ionized	ADJ
admet-621	66	36	form	form	NOUN
admet-621	66	37	i.e.	i.e.	X
admet-621	66	38	sodium	sodium	NOUN
admet-621	66	39	phenytoin	phenytoin	NOUN
admet-621	66	40	in	in	ADP
admet-621	66	41	water	water	NOUN
admet-621	66	42	and	and	CCONJ
admet-621	66	43	lamotrigine	lamotrigine	NOUN
admet-621	66	44	in	in	ADP
admet-621	66	45	hcl	hcl	PROPN
admet-621	66	46	(	(	PUNCT
admet-621	66	47	0.1	0.1	NUM
admet-621	66	48	m	m	PROPN
admet-621	66	49	)	)	PUNCT
admet-621	66	50	.	.	PUNCT
admet-621	67	1	one	one	NUM
admet-621	67	2	of	of	ADP
admet-621	67	3	the	the	DET
admet-621	67	4	reasons	reason	NOUN
admet-621	67	5	for	for	ADP
admet-621	67	6	change	change	NOUN
admet-621	67	7	in	in	ADP
admet-621	67	8	solubility	solubility	NOUN
admet-621	67	9	in	in	ADP
admet-621	67	10	the	the	DET
admet-621	67	11	presence	presence	NOUN
admet-621	67	12	of	of	ADP
admet-621	67	13	different	different	ADJ
admet-621	67	14	values	value	NOUN
admet-621	67	15	of	of	ADP
admet-621	67	16	excess	excess	ADJ
admet-621	67	17	solid	solid	NOUN
admet-621	67	18	is	be	AUX
admet-621	67	19	change	change	NOUN
admet-621	67	20	in	in	ADP
admet-621	67	21	ph	ph	NOUN
admet-621	67	22	of	of	ADP
admet-621	67	23	saturated	saturate	VERB
admet-621	67	24	solution	solution	NOUN
admet-621	67	25	[	[	X
admet-621	67	26	20	20	NUM
admet-621	67	27	]	]	PUNCT
admet-621	67	28	.	.	PUNCT
admet-621	68	1	in	in	ADP
admet-621	68	2	this	this	DET
admet-621	68	3	study	study	NOUN
admet-621	68	4	,	,	PUNCT
admet-621	68	5	solubility	solubility	NOUN
admet-621	68	6	was	be	AUX
admet-621	68	7	determined	determine	VERB
admet-621	68	8	in	in	ADP
admet-621	68	9	aqueous	aqueous	ADJ
admet-621	68	10	solution	solution	NOUN
admet-621	68	11	at	at	ADP
admet-621	68	12	own	own	ADJ
admet-621	68	13	ph	ph	NOUN
admet-621	68	14	.	.	PUNCT
admet-621	69	1	however	however	ADV
admet-621	69	2	,	,	PUNCT
admet-621	69	3	ph	ph	ADJ
admet-621	69	4	determination	determination	NOUN
admet-621	69	5	of	of	ADP
admet-621	69	6	final	final	ADJ
admet-621	69	7	solutions	solution	NOUN
admet-621	69	8	(	(	PUNCT
admet-621	69	9	various	various	ADJ
admet-621	69	10	excess	excess	ADJ
admet-621	69	11	amounts	amount	NOUN
admet-621	69	12	)	)	PUNCT
admet-621	69	13	showed	show	VERB
admet-621	69	14	no	no	DET
admet-621	69	15	substantial	substantial	ADJ
admet-621	69	16	change	change	NOUN
admet-621	69	17	(	(	PUNCT
admet-621	69	18	ph	ph	NOUN
admet-621	69	19	:	:	PUNCT
admet-621	69	20	11.6±0.05	11.6±0.05	NUM
admet-621	69	21	)	)	PUNCT
admet-621	69	22	.	.	PUNCT
admet-621	70	1	a	a	DET
admet-621	70	2	differential	differential	NOUN
admet-621	70	3	scanning	scan	VERB
admet-621	70	4	calorimetry	calorimetry	NOUN
admet-621	70	5	(	(	PUNCT
admet-621	70	6	dsc	dsc	NOUN
admet-621	70	7	)	)	PUNCT
admet-621	70	8	study	study	NOUN
admet-621	70	9	of	of	ADP
admet-621	70	10	the	the	DET
admet-621	70	11	remaining	remain	VERB
admet-621	70	12	solid	solid	ADJ
admet-621	70	13	of	of	ADP
admet-621	70	14	lamotrigine	lamotrigine	NOUN
admet-621	70	15	confirms	confirm	VERB
admet-621	70	16	no	no	DET
admet-621	70	17	possible	possible	ADJ
admet-621	70	18	change	change	NOUN
admet-621	70	19	in	in	ADP
admet-621	70	20	crystalline	crystalline	ADJ
admet-621	70	21	phase	phase	NOUN
admet-621	70	22	due	due	ADP
admet-621	70	23	to	to	ADP
admet-621	70	24	a	a	DET
admet-621	70	25	sharp	sharp	ADJ
admet-621	70	26	peak	peak	NOUN
admet-621	70	27	corresponding	correspond	VERB
admet-621	70	28	to	to	ADP
admet-621	70	29	lamotrigine	lamotrigine	NOUN
admet-621	70	30	melting	melting	NOUN
admet-621	70	31	at	at	ADP
admet-621	70	32	220	220	NUM
admet-621	70	33	°	°	NOUN
admet-621	70	34	c	c	NOUN
admet-621	70	35	,	,	PUNCT
admet-621	70	36	being	be	AUX
admet-621	70	37	in	in	ADP
admet-621	70	38	agreement	agreement	NOUN
admet-621	70	39	with	with	ADP
admet-621	70	40	the	the	DET
admet-621	70	41	literature	literature	NOUN
admet-621	70	42	[	[	X
admet-621	70	43	19	19	NUM
admet-621	70	44	]	]	PUNCT
admet-621	70	45	.	.	PUNCT
admet-621	71	1	however	however	ADV
admet-621	71	2	,	,	PUNCT
admet-621	71	3	dsc	dsc	PROPN
admet-621	71	4	thermogram	thermogram	PROPN
admet-621	71	5	sodium	sodium	PROPN
admet-621	71	6	phenytoin	phenytoin	NOUN
admet-621	71	7	in	in	ADP
admet-621	71	8	water	water	NOUN
admet-621	71	9	exhibited	exhibit	VERB
admet-621	71	10	some	some	DET
admet-621	71	11	new	new	ADJ
admet-621	71	12	peaks	peak	NOUN
admet-621	71	13	resultant	resultant	VERB
admet-621	71	14	to	to	PART
admet-621	71	15	phase	phase	VERB
admet-621	71	16	transformation	transformation	NOUN
admet-621	71	17	of	of	ADP
admet-621	71	18	drug	drug	NOUN
admet-621	71	19	to	to	ADP
admet-621	71	20	the	the	DET
admet-621	71	21	hexahydrate	hexahydrate	NOUN
admet-621	71	22	form	form	NOUN
admet-621	71	23	similar	similar	ADJ
admet-621	71	24	to	to	ADP
admet-621	71	25	the	the	DET
admet-621	71	26	reported	report	VERB
admet-621	71	27	study	study	NOUN
admet-621	71	28	by	by	ADP
admet-621	71	29	rubino	rubino	PROPN
admet-621	72	1	[	[	X
admet-621	72	2	21	21	NUM
admet-621	72	3	]	]	PUNCT
admet-621	72	4	,	,	PUNCT
admet-621	72	5	and	and	CCONJ
admet-621	72	6	it	it	PRON
admet-621	72	7	is	be	AUX
admet-621	72	8	not	not	PART
admet-621	72	9	possible	possible	ADJ
admet-621	72	10	to	to	PART
admet-621	72	11	judge	judge	VERB
admet-621	72	12	about	about	ADP
admet-621	72	13	the	the	DET
admet-621	72	14	polymorphic	polymorphic	ADJ
admet-621	72	15	change	change	NOUN
admet-621	72	16	or	or	CCONJ
admet-621	72	17	dimer	dimer	VERB
admet-621	72	18	formation	formation	NOUN
admet-621	72	19	whenever	whenever	SCONJ
admet-621	72	20	the	the	DET
admet-621	72	21	amount	amount	NOUN
admet-621	72	22	of	of	ADP
admet-621	72	23	excess	excess	ADJ
admet-621	72	24	solid	solid	NOUN
admet-621	72	25	is	be	AUX
admet-621	72	26	changed	change	VERB
admet-621	72	27	.	.	PUNCT
admet-621	73	1	kawakami	kawakami	PROPN
admet-621	73	2	et	et	PROPN
admet-621	73	3	al	al	PROPN
admet-621	73	4	.	.	PUNCT
admet-621	74	1	[	[	X
admet-621	74	2	13	13	NUM
admet-621	74	3	]	]	PUNCT
admet-621	74	4	have	have	AUX
admet-621	74	5	reported	report	VERB
admet-621	74	6	that	that	SCONJ
admet-621	74	7	solubility	solubility	NOUN
admet-621	74	8	of	of	ADP
admet-621	74	9	indomethacin	indomethacin	NOUN
admet-621	74	10	increased	increase	VERB
admet-621	74	11	with	with	ADP
admet-621	74	12	an	an	DET
admet-621	74	13	increase	increase	NOUN
admet-621	74	14	in	in	ADP
admet-621	74	15	the	the	DET
admet-621	74	16	solid	solid	ADJ
admet-621	74	17	amount	amount	NOUN
admet-621	74	18	in	in	ADP
admet-621	74	19	ionizable	ionizable	ADJ
admet-621	74	20	form	form	NOUN
admet-621	74	21	(	(	PUNCT
admet-621	74	22	ph=6.5	ph=6.5	X
admet-621	74	23	-	-	SYM
admet-621	74	24	7	7	NUM
admet-621	74	25	)	)	PUNCT
admet-621	74	26	against	against	ADP
admet-621	74	27	indomethacin	indomethacin	NOUN
admet-621	74	28	solubility	solubility	NOUN
admet-621	74	29	in	in	ADP
admet-621	74	30	non	non	ADJ
admet-621	74	31	-	-	ADJ
admet-621	74	32	ionizable	ionizable	ADJ
admet-621	74	33	form	form	NOUN
admet-621	74	34	(	(	PUNCT
admet-621	74	35	ph=5	ph=5	NOUN
admet-621	74	36	)	)	PUNCT
admet-621	74	37	.	.	PUNCT
admet-621	75	1	they	they	PRON
admet-621	75	2	discussed	discuss	VERB
admet-621	75	3	the	the	DET
admet-621	75	4	anomalous	anomalous	ADJ
admet-621	75	5	behavior	behavior	NOUN
admet-621	75	6	in	in	ADP
admet-621	75	7	dissolution	dissolution	NOUN
admet-621	75	8	and	and	CCONJ
admet-621	75	9	crystallization	crystallization	NOUN
admet-621	75	10	rates	rate	NOUN
admet-621	75	11	at	at	ADP
admet-621	75	12	near	near	ADP
admet-621	75	13	equilibrium	equilibrium	NOUN
admet-621	75	14	conditions	condition	NOUN
admet-621	75	15	as	as	ADP
admet-621	75	16	the	the	DET
admet-621	75	17	possible	possible	ADJ
admet-621	75	18	mechanism	mechanism	NOUN
admet-621	75	19	.	.	PUNCT
admet-621	76	1	however	however	ADV
admet-621	76	2	,	,	PUNCT
admet-621	76	3	one	one	NUM
admet-621	76	4	of	of	ADP
admet-621	76	5	the	the	DET
admet-621	76	6	potential	potential	ADJ
admet-621	76	7	reasons	reason	NOUN
admet-621	76	8	based	base	VERB
admet-621	76	9	on	on	ADP
admet-621	76	10	avdeef	avdeef	PROPN
admet-621	76	11	’s	’s	PART
admet-621	76	12	comment	comment	NOUN
admet-621	76	13	on	on	ADP
admet-621	76	14	that	that	DET
admet-621	76	15	study	study	NOUN
admet-621	76	16	is	be	AUX
admet-621	76	17	the	the	DET
admet-621	76	18	possible	possible	ADJ
admet-621	76	19	partitioning	partitioning	NOUN
admet-621	76	20	(	(	PUNCT
admet-621	76	21	adsorption	adsorption	NOUN
admet-621	76	22	)	)	PUNCT
admet-621	76	23	of	of	ADP
admet-621	76	24	the	the	DET
admet-621	76	25	charged	charge	VERB
admet-621	76	26	form	form	NOUN
admet-621	76	27	of	of	ADP
admet-621	76	28	indomethacin	indomethacin	NOUN
admet-621	76	29	onto	onto	ADP
admet-621	76	30	the	the	DET
admet-621	76	31	excess	excess	ADJ
admet-621	76	32	solid	solid	ADJ
admet-621	76	33	present	present	NOUN
admet-621	76	34	in	in	ADP
admet-621	76	35	the	the	DET
admet-621	76	36	suspensions	suspension	NOUN
admet-621	76	37	,	,	PUNCT
admet-621	76	38	and	and	CCONJ
admet-621	76	39	some	some	DET
admet-621	76	40	ionizable	ionizable	ADJ
admet-621	76	41	compounds	compound	NOUN
admet-621	76	42	may	may	AUX
admet-621	76	43	be	be	AUX
admet-621	76	44	surface	surface	NOUN
admet-621	76	45	-	-	PUNCT
admet-621	76	46	active	active	ADJ
admet-621	76	47	.	.	PUNCT
admet-621	77	1	however	however	ADV
admet-621	77	2	,	,	PUNCT
admet-621	77	3	further	further	ADJ
admet-621	77	4	mechanisms	mechanism	NOUN
admet-621	77	5	such	such	ADJ
admet-621	77	6	as	as	ADP
admet-621	77	7	dimer	dimer	NOUN
admet-621	77	8	formation	formation	NOUN
admet-621	77	9	are	be	AUX
admet-621	77	10	possible	possible	ADJ
admet-621	77	11	,	,	PUNCT
admet-621	77	12	and	and	CCONJ
admet-621	77	13	the	the	DET
admet-621	77	14	results	result	NOUN
admet-621	77	15	are	be	AUX
admet-621	77	16	not	not	PART
admet-621	77	17	interpretable	interpretable	ADJ
admet-621	77	18	without	without	ADP
admet-621	77	19	analysis	analysis	NOUN
admet-621	77	20	of	of	ADP
admet-621	77	21	the	the	DET
admet-621	77	22	solid	solid	ADJ
admet-621	77	23	form	form	NOUN
admet-621	77	24	[	[	X
admet-621	77	25	15	15	NUM
admet-621	77	26	]	]	PUNCT
admet-621	77	27	.	.	PUNCT
admet-621	78	1	nevertheless	nevertheless	ADV
admet-621	78	2	,	,	PUNCT
admet-621	78	3	a	a	DET
admet-621	78	4	similar	similar	ADJ
admet-621	78	5	research	research	NOUN
admet-621	78	6	study	study	NOUN
admet-621	78	7	about	about	ADP
admet-621	78	8	solubility	solubility	NOUN
admet-621	78	9	measurement	measurement	NOUN
admet-621	78	10	of	of	ADP
admet-621	78	11	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-621	78	12	reported	report	VERB
admet-621	78	13	no	no	DET
admet-621	78	14	significant	significant	ADJ
admet-621	78	15	difference	difference	NOUN
admet-621	78	16	for	for	ADP
admet-621	78	17	solubility	solubility	NOUN
admet-621	78	18	values	value	NOUN
admet-621	78	19	in	in	ADP
admet-621	78	20	water	water	NOUN
admet-621	78	21	when	when	SCONJ
admet-621	78	22	different	different	ADJ
admet-621	78	23	excess	excess	ADJ
admet-621	78	24	amounts	amount	NOUN
admet-621	78	25	of	of	ADP
admet-621	78	26	the	the	DET
admet-621	78	27	drug	drug	NOUN
admet-621	78	28	were	be	AUX
admet-621	78	29	used	use	VERB
admet-621	78	30	[	[	PUNCT
admet-621	78	31	8	8	NUM
admet-621	78	32	]	]	PUNCT
admet-621	78	33	.	.	PUNCT
admet-621	79	1	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-621	79	2	as	as	ADP
admet-621	79	3	an	an	DET
admet-621	79	4	acidic	acidic	ADJ
admet-621	79	5	compound	compound	NOUN
admet-621	79	6	converts	convert	NOUN
admet-621	79	7	to	to	ADP
admet-621	79	8	non	non	ADJ
admet-621	79	9	-	-	ADJ
admet-621	79	10	ionized	ionized	ADJ
admet-621	79	11	form	form	NOUN
admet-621	79	12	in	in	ADP
admet-621	79	13	saturated	saturate	VERB
admet-621	79	14	aqueous	aqueous	ADJ
admet-621	79	15	solution	solution	NOUN
admet-621	79	16	.	.	PUNCT
admet-621	80	1	another	another	DET
admet-621	80	2	study	study	NOUN
admet-621	80	3	by	by	ADP
admet-621	80	4	mosharraf	mosharraf	NOUN
admet-621	80	5	et	et	PROPN
admet-621	80	6	al	al	PROPN
admet-621	80	7	.	.	PUNCT
admet-621	81	1	[	[	X
admet-621	81	2	22	22	NUM
admet-621	81	3	]	]	PUNCT
admet-621	81	4	reported	report	VERB
admet-621	81	5	that	that	SCONJ
admet-621	81	6	solubility	solubility	NOUN
admet-621	81	7	of	of	ADP
admet-621	81	8	chemical	chemical	NOUN
admet-621	81	9	compounds	compound	NOUN
admet-621	81	10	(	(	PUNCT
admet-621	81	11	in	in	ADP
admet-621	81	12	salt	salt	NOUN
admet-621	81	13	form	form	NOUN
admet-621	81	14	)	)	PUNCT
admet-621	81	15	was	be	AUX
admet-621	81	16	affected	affect	VERB
admet-621	81	17	by	by	ADP
admet-621	81	18	the	the	DET
admet-621	81	19	amount	amount	NOUN
admet-621	81	20	of	of	ADP
admet-621	81	21	excess	excess	ADJ
admet-621	81	22	solid	solid	ADJ
admet-621	81	23	.	.	PUNCT
admet-621	82	1	increasing	increase	VERB
admet-621	82	2	the	the	DET
admet-621	82	3	amount	amount	NOUN
admet-621	82	4	of	of	ADP
admet-621	82	5	excess	excess	ADJ
admet-621	82	6	solid	solid	NOUN
admet-621	82	7	of	of	ADP
admet-621	82	8	barium	barium	NOUN
admet-621	82	9	sulphate	sulphate	NOUN
admet-621	82	10	or	or	CCONJ
admet-621	82	11	calcium	calcium	NOUN
admet-621	82	12	carbonate	carbonate	NOUN
admet-621	82	13	can	can	AUX
admet-621	82	14	affect	affect	VERB
admet-621	82	15	solubility	solubility	NOUN
admet-621	82	16	value	value	NOUN
admet-621	82	17	due	due	ADP
admet-621	82	18	to	to	ADP
admet-621	82	19	the	the	DET
admet-621	82	20	disordering	disorder	VERB
admet-621	82	21	particle	particle	NOUN
admet-621	82	22	surface	surface	NOUN
admet-621	82	23	and	and	CCONJ
admet-621	82	24	existence	existence	NOUN
admet-621	82	25	of	of	ADP
admet-621	82	26	a	a	DET
admet-621	82	27	peripheral	peripheral	ADJ
admet-621	82	28	disordered	disordered	ADJ
admet-621	82	29	layer	layer	NOUN
admet-621	82	30	.	.	PUNCT
admet-621	83	1	according	accord	VERB
admet-621	83	2	to	to	ADP
admet-621	83	3	the	the	DET
admet-621	83	4	obtained	obtain	VERB
admet-621	83	5	study	study	NOUN
admet-621	83	6	,	,	PUNCT
admet-621	83	7	solubility	solubility	NOUN
admet-621	83	8	of	of	ADP
admet-621	83	9	chemical	chemical	NOUN
admet-621	83	10	compounds	compound	NOUN
admet-621	83	11	can	can	AUX
admet-621	83	12	change	change	VERB
admet-621	83	13	by	by	ADP
admet-621	83	14	the	the	DET
admet-621	83	15	amount	amount	NOUN
admet-621	83	16	of	of	ADP
admet-621	83	17	excess	excess	NOUN
admet-621	83	18	solid	solid	ADJ
admet-621	83	19	,	,	PUNCT
admet-621	83	20	and	and	CCONJ
admet-621	83	21	the	the	DET
admet-621	83	22	mutual	mutual	ADJ
admet-621	83	23	issue	issue	NOUN
admet-621	83	24	between	between	ADP
admet-621	83	25	the	the	DET
admet-621	83	26	reported	report	VERB
admet-621	83	27	studies	study	NOUN
admet-621	83	28	is	be	AUX
admet-621	83	29	ionization	ionization	NOUN
admet-621	83	30	and	and	CCONJ
admet-621	83	31	salt	salt	NOUN
admet-621	83	32	form	form	NOUN
admet-621	83	33	of	of	ADP
admet-621	83	34	solute	solute	NOUN
admet-621	83	35	.	.	PUNCT
admet-621	84	1	change	change	NOUN
admet-621	84	2	in	in	ADP
admet-621	84	3	the	the	DET
admet-621	84	4	diffusion	diffusion	NOUN
admet-621	84	5	layer	layer	NOUN
admet-621	84	6	and	and	CCONJ
admet-621	84	7	disordering	disorder	VERB
admet-621	84	8	particle	particle	NOUN
admet-621	84	9	surface	surface	NOUN
admet-621	84	10	due	due	ADP
admet-621	84	11	to	to	ADP
admet-621	84	12	adsorption	adsorption	NOUN
admet-621	84	13	of	of	ADP
admet-621	84	14	the	the	DET
admet-621	84	15	charged	charge	VERB
admet-621	84	16	form	form	NOUN
admet-621	84	17	of	of	ADP
admet-621	84	18	the	the	DET
admet-621	84	19	drug	drug	NOUN
admet-621	84	20	and	and	CCONJ
admet-621	84	21	admet	admet	PROPN
admet-621	84	22	&	&	CCONJ
admet-621	84	23	dmpk	dmpk	PROPN
admet-621	84	24	6(4	6(4	PROPN
admet-621	84	25	)	)	PUNCT
admet-621	84	26	(	(	PUNCT
admet-621	84	27	2018	2018	NUM
admet-621	84	28	)	)	PUNCT
admet-621	84	29	269	269	NUM
admet-621	84	30	-	-	SYM
admet-621	84	31	278	278	NUM
admet-621	84	32	solubility	solubility	NOUN
admet-621	84	33	of	of	ADP
admet-621	84	34	sodium	sodium	NOUN
admet-621	84	35	phenytoin	phenytoin	NOUN
admet-621	84	36	and	and	CCONJ
admet-621	84	37	lamotrigine	lamotrigine	ADJ
admet-621	84	38	doi	doi	NOUN
admet-621	84	39	:	:	PUNCT
admet-621	84	40	10.5599	10.5599	NUM
admet-621	84	41	/	/	SYM
admet-621	84	42	admet.621	admet.621	PROPN
admet-621	84	43	273	273	NUM
admet-621	84	44	surface	surface	NOUN
admet-621	84	45	activity	activity	NOUN
admet-621	84	46	of	of	ADP
admet-621	84	47	solute	solute	NOUN
admet-621	84	48	in	in	ADP
admet-621	84	49	ionized	ionized	ADJ
admet-621	84	50	form	form	NOUN
admet-621	84	51	could	could	AUX
admet-621	84	52	be	be	AUX
admet-621	84	53	an	an	DET
admet-621	84	54	acceptable	acceptable	ADJ
admet-621	84	55	interpretation	interpretation	NOUN
admet-621	84	56	for	for	ADP
admet-621	84	57	increasing	increase	VERB
admet-621	84	58	solubility	solubility	NOUN
admet-621	84	59	values	value	NOUN
admet-621	84	60	in	in	ADP
admet-621	84	61	the	the	DET
admet-621	84	62	higher	high	ADJ
admet-621	84	63	amount	amount	NOUN
admet-621	84	64	of	of	ADP
admet-621	84	65	excess	excess	ADJ
admet-621	84	66	solids	solid	NOUN
admet-621	84	67	.	.	PUNCT
admet-621	85	1	similar	similar	ADJ
admet-621	85	2	phenomena	phenomenon	NOUN
admet-621	85	3	have	have	AUX
admet-621	85	4	been	be	AUX
admet-621	85	5	proposed	propose	VERB
admet-621	85	6	for	for	ADP
admet-621	85	7	increase	increase	NOUN
admet-621	85	8	in	in	ADP
admet-621	85	9	saturation	saturation	NOUN
admet-621	85	10	solubility	solubility	NOUN
admet-621	85	11	of	of	ADP
admet-621	85	12	nanocrystals	nanocrystal	NOUN
admet-621	85	13	(	(	PUNCT
admet-621	85	14	size	size	NOUN
admet-621	85	15	of	of	ADP
admet-621	85	16	particle	particle	NOUN
admet-621	85	17	less	less	ADJ
admet-621	85	18	than	than	ADP
admet-621	85	19	1000	1000	NUM
admet-621	85	20	nm	nm	NOUN
admet-621	85	21	)	)	PUNCT
admet-621	85	22	by	by	ADP
admet-621	85	23	the	the	DET
admet-621	85	24	change	change	NOUN
admet-621	85	25	in	in	ADP
admet-621	85	26	layer	layer	NOUN
admet-621	85	27	of	of	ADP
admet-621	85	28	unstirred	unstirred	ADJ
admet-621	85	29	layer	layer	NOUN
admet-621	85	30	surrounding	surround	VERB
admet-621	85	31	the	the	DET
admet-621	85	32	drug	drug	NOUN
admet-621	85	33	particle	particle	NOUN
admet-621	85	34	(	(	PUNCT
admet-621	85	35	diffusion	diffusion	NOUN
admet-621	85	36	layer	layer	NOUN
admet-621	85	37	)	)	PUNCT
admet-621	86	1	[	[	X
admet-621	86	2	23	23	NUM
admet-621	86	3	]	]	PUNCT
admet-621	86	4	.	.	PUNCT
admet-621	87	1	moreover	moreover	ADV
admet-621	87	2	,	,	PUNCT
admet-621	87	3	when	when	SCONJ
admet-621	87	4	drug	drug	NOUN
admet-621	87	5	salts	salt	NOUN
admet-621	87	6	are	be	AUX
admet-621	87	7	added	add	VERB
admet-621	87	8	to	to	ADP
admet-621	87	9	solution	solution	NOUN
admet-621	87	10	,	,	PUNCT
admet-621	87	11	their	their	PRON
admet-621	87	12	solubility	solubility	NOUN
admet-621	87	13	is	be	AUX
admet-621	87	14	expected	expect	VERB
admet-621	87	15	to	to	PART
admet-621	87	16	vary	vary	VERB
admet-621	87	17	according	accord	VERB
admet-621	87	18	to	to	ADP
admet-621	87	19	the	the	DET
admet-621	87	20	amount	amount	NOUN
admet-621	87	21	of	of	ADP
admet-621	87	22	solid	solid	ADJ
admet-621	87	23	added	add	VERB
admet-621	87	24	,	,	PUNCT
admet-621	87	25	since	since	SCONJ
admet-621	87	26	the	the	DET
admet-621	87	27	solubility	solubility	NOUN
admet-621	87	28	product	product	NOUN
admet-621	87	29	may	may	AUX
admet-621	87	30	not	not	PART
admet-621	87	31	be	be	AUX
admet-621	87	32	satisfied	satisfied	ADJ
admet-621	87	33	below	below	ADP
admet-621	87	34	a	a	DET
admet-621	87	35	certain	certain	ADJ
admet-621	87	36	amount	amount	NOUN
admet-621	87	37	of	of	ADP
admet-621	87	38	added	add	VERB
admet-621	87	39	salt	salt	NOUN
admet-621	87	40	.	.	PUNCT
admet-621	88	1	the	the	DET
admet-621	88	2	partial	partial	ADJ
admet-621	88	3	conversion	conversion	NOUN
admet-621	88	4	back	back	ADV
admet-621	88	5	of	of	ADP
admet-621	88	6	sodium	sodium	NOUN
admet-621	88	7	phenytoin	phenytoin	NOUN
admet-621	88	8	to	to	ADP
admet-621	88	9	free	free	ADJ
admet-621	88	10	acid	acid	NOUN
admet-621	88	11	form	form	NOUN
admet-621	88	12	during	during	ADP
admet-621	88	13	solubility	solubility	NOUN
admet-621	88	14	testing	testing	NOUN
admet-621	88	15	reported	report	VERB
admet-621	88	16	by	by	ADP
admet-621	88	17	chaing	chae	VERB
admet-621	88	18	and	and	CCONJ
admet-621	88	19	wang	wang	PROPN
admet-621	89	1	[	[	X
admet-621	89	2	24	24	NUM
admet-621	89	3	]	]	X
admet-621	89	4	could	could	AUX
admet-621	89	5	be	be	AUX
admet-621	89	6	reason	reason	NOUN
admet-621	89	7	for	for	ADP
admet-621	89	8	variability	variability	NOUN
admet-621	89	9	in	in	ADP
admet-621	89	10	the	the	DET
admet-621	89	11	solubility	solubility	NOUN
admet-621	89	12	values	value	NOUN
admet-621	89	13	.	.	PUNCT
admet-621	90	1	the	the	DET
admet-621	90	2	effect	effect	NOUN
admet-621	90	3	of	of	ADP
admet-621	90	4	type	type	NOUN
admet-621	90	5	of	of	ADP
admet-621	90	6	stirring	stirring	NOUN
admet-621	90	7	and	and	CCONJ
admet-621	90	8	sedimentation	sedimentation	NOUN
admet-621	90	9	time	time	NOUN
admet-621	90	10	on	on	ADP
admet-621	90	11	solubility	solubility	NOUN
admet-621	90	12	of	of	ADP
admet-621	90	13	lamotrigine	lamotrigine	PROPN
admet-621	90	14	and	and	CCONJ
admet-621	90	15	phenytoin	phenytoin	ADJ
admet-621	90	16	sodium	sodium	NOUN
admet-621	90	17	type	type	NOUN
admet-621	90	18	of	of	ADP
admet-621	90	19	stirring	stirring	NOUN
admet-621	90	20	is	be	AUX
admet-621	90	21	a	a	DET
admet-621	90	22	critical	critical	ADJ
admet-621	90	23	parameter	parameter	NOUN
admet-621	90	24	in	in	ADP
admet-621	90	25	evaluating	evaluate	VERB
admet-621	90	26	dissolution	dissolution	NOUN
admet-621	90	27	of	of	ADP
admet-621	90	28	pharmaceuticals	pharmaceutical	NOUN
admet-621	90	29	[	[	X
admet-621	90	30	24	24	NUM
admet-621	90	31	]	]	PUNCT
admet-621	90	32	.	.	PUNCT
admet-621	91	1	however	however	ADV
admet-621	91	2	,	,	PUNCT
admet-621	91	3	it	it	PRON
admet-621	91	4	has	have	AUX
admet-621	91	5	been	be	AUX
admet-621	91	6	not	not	PART
admet-621	91	7	yet	yet	ADV
admet-621	91	8	considered	consider	VERB
admet-621	91	9	as	as	ADP
admet-621	91	10	an	an	DET
admet-621	91	11	effective	effective	ADJ
admet-621	91	12	factor	factor	NOUN
admet-621	91	13	in	in	ADP
admet-621	91	14	solubility	solubility	NOUN
admet-621	91	15	determination	determination	NOUN
admet-621	91	16	of	of	ADP
admet-621	91	17	solute	solute	NOUN
admet-621	91	18	.	.	PUNCT
admet-621	92	1	magnetic	magnetic	ADJ
admet-621	92	2	stirrer	stirrer	NOUN
admet-621	92	3	and	and	CCONJ
admet-621	92	4	shake	shake	NOUN
admet-621	92	5	-	-	PUNCT
admet-621	92	6	flask	flask	NOUN
admet-621	92	7	are	be	AUX
admet-621	92	8	common	common	ADJ
admet-621	92	9	approaches	approach	NOUN
admet-621	92	10	in	in	ADP
admet-621	92	11	the	the	DET
admet-621	92	12	literature	literature	NOUN
admet-621	92	13	to	to	PART
admet-621	92	14	attain	attain	VERB
admet-621	92	15	the	the	DET
admet-621	92	16	solution	solution	NOUN
admet-621	92	17	to	to	ADP
admet-621	92	18	equilibrium	equilibrium	NOUN
admet-621	92	19	.	.	PUNCT
admet-621	93	1	type	type	NOUN
admet-621	93	2	of	of	ADP
admet-621	93	3	stirring	stirring	NOUN
admet-621	93	4	could	could	AUX
admet-621	93	5	be	be	AUX
admet-621	93	6	considered	consider	VERB
admet-621	93	7	as	as	ADP
admet-621	93	8	a	a	DET
admet-621	93	9	possible	possible	ADJ
admet-621	93	10	reason	reason	NOUN
admet-621	93	11	for	for	ADP
admet-621	93	12	the	the	DET
admet-621	93	13	variation	variation	NOUN
admet-621	93	14	of	of	ADP
admet-621	93	15	solubility	solubility	NOUN
admet-621	93	16	values	value	NOUN
admet-621	93	17	because	because	SCONJ
admet-621	93	18	of	of	ADP
admet-621	93	19	supersaturation	supersaturation	NOUN
admet-621	93	20	phenomenon	phenomenon	NOUN
admet-621	93	21	.	.	PUNCT
admet-621	94	1	it	it	PRON
admet-621	94	2	is	be	AUX
admet-621	94	3	a	a	DET
admet-621	94	4	state	state	NOUN
admet-621	94	5	of	of	ADP
admet-621	94	6	a	a	DET
admet-621	94	7	solution	solution	NOUN
admet-621	94	8	that	that	PRON
admet-621	94	9	contains	contain	VERB
admet-621	94	10	more	more	ADJ
admet-621	94	11	of	of	ADP
admet-621	94	12	the	the	DET
admet-621	94	13	dissolved	dissolve	VERB
admet-621	94	14	material	material	NOUN
admet-621	94	15	than	than	SCONJ
admet-621	94	16	could	could	AUX
admet-621	94	17	be	be	AUX
admet-621	94	18	dissolved	dissolve	VERB
admet-621	94	19	in	in	ADP
admet-621	94	20	the	the	DET
admet-621	94	21	solvent	solvent	NOUN
admet-621	94	22	[	[	X
admet-621	94	23	7	7	NUM
admet-621	94	24	]	]	PUNCT
admet-621	94	25	.	.	PUNCT
admet-621	95	1	the	the	DET
admet-621	95	2	results	result	NOUN
admet-621	95	3	in	in	ADP
admet-621	95	4	figures	figure	NOUN
admet-621	95	5	6	6	NUM
admet-621	95	6	-	-	SYM
admet-621	95	7	9	9	NUM
admet-621	95	8	show	show	NOUN
admet-621	95	9	that	that	DET
admet-621	95	10	type	type	NOUN
admet-621	95	11	of	of	ADP
admet-621	95	12	stirring	stirring	NOUN
admet-621	95	13	has	have	VERB
admet-621	95	14	a	a	DET
admet-621	95	15	slight	slight	ADJ
admet-621	95	16	effect	effect	NOUN
admet-621	95	17	on	on	ADP
admet-621	95	18	obtained	obtain	VERB
admet-621	95	19	solubility	solubility	NOUN
admet-621	95	20	for	for	ADP
admet-621	95	21	lamotrigine	lamotrigine	NOUN
admet-621	95	22	and	and	CCONJ
admet-621	95	23	phenytoin	phenytoin	ADJ
admet-621	95	24	sodium	sodium	NOUN
admet-621	95	25	.	.	PUNCT
admet-621	96	1	however	however	ADV
admet-621	96	2	,	,	PUNCT
admet-621	96	3	sedimentation	sedimentation	NOUN
admet-621	96	4	time	time	NOUN
admet-621	96	5	after	after	ADP
admet-621	96	6	24	24	NUM
admet-621	96	7	-	-	PUNCT
admet-621	96	8	hour	hour	NOUN
admet-621	96	9	,	,	PUNCT
admet-621	96	10	in	in	ADP
admet-621	96	11	both	both	DET
admet-621	96	12	types	type	NOUN
admet-621	96	13	of	of	ADP
admet-621	96	14	stirring	stirring	NOUN
admet-621	96	15	,	,	PUNCT
admet-621	96	16	has	have	VERB
admet-621	96	17	a	a	DET
admet-621	96	18	considerable	considerable	ADJ
admet-621	96	19	effect	effect	NOUN
admet-621	96	20	on	on	ADP
admet-621	96	21	solubility	solubility	NOUN
admet-621	96	22	values	value	NOUN
admet-621	96	23	.	.	PUNCT
admet-621	97	1	in	in	ADP
admet-621	97	2	this	this	DET
admet-621	97	3	regard	regard	NOUN
admet-621	97	4	,	,	PUNCT
admet-621	97	5	baka	baka	PROPN
admet-621	97	6	et	et	PROPN
admet-621	97	7	al	al	PROPN
admet-621	97	8	.	.	PUNCT
admet-621	98	1	[	[	X
admet-621	98	2	8	8	NUM
admet-621	98	3	]	]	PUNCT
admet-621	98	4	conducted	conduct	VERB
admet-621	98	5	the	the	DET
admet-621	98	6	only	only	ADJ
admet-621	98	7	study	study	NOUN
admet-621	98	8	about	about	ADP
admet-621	98	9	the	the	DET
admet-621	98	10	effect	effect	NOUN
admet-621	98	11	of	of	ADP
admet-621	98	12	sedimentation	sedimentation	NOUN
admet-621	98	13	time	time	NOUN
admet-621	98	14	for	for	ADP
admet-621	98	15	solubility	solubility	NOUN
admet-621	98	16	of	of	ADP
admet-621	98	17	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-621	98	18	;	;	PUNCT
admet-621	98	19	similar	similar	ADJ
admet-621	98	20	to	to	ADP
admet-621	98	21	the	the	DET
admet-621	98	22	results	result	NOUN
admet-621	98	23	of	of	ADP
admet-621	98	24	this	this	DET
admet-621	98	25	study	study	NOUN
admet-621	98	26	,	,	PUNCT
admet-621	98	27	sedimentation	sedimentation	NOUN
admet-621	98	28	time	time	NOUN
admet-621	98	29	had	have	VERB
admet-621	98	30	a	a	DET
admet-621	98	31	considerable	considerable	ADJ
admet-621	98	32	effect	effect	NOUN
admet-621	98	33	on	on	ADP
admet-621	98	34	the	the	DET
admet-621	98	35	aqueous	aqueous	ADJ
admet-621	98	36	solubility	solubility	NOUN
admet-621	98	37	of	of	ADP
admet-621	98	38	drug	drug	NOUN
admet-621	98	39	.	.	PUNCT
admet-621	99	1	the	the	DET
admet-621	99	2	results	result	NOUN
admet-621	99	3	of	of	ADP
admet-621	99	4	this	this	DET
admet-621	99	5	study	study	NOUN
admet-621	99	6	indicate	indicate	VERB
admet-621	99	7	that	that	SCONJ
admet-621	99	8	although	although	SCONJ
admet-621	99	9	solubility	solubility	NOUN
admet-621	99	10	determination	determination	NOUN
admet-621	99	11	of	of	ADP
admet-621	99	12	drugs	drug	NOUN
admet-621	99	13	seems	seem	VERB
admet-621	99	14	a	a	DET
admet-621	99	15	simple	simple	ADJ
admet-621	99	16	experiment	experiment	NOUN
admet-621	99	17	,	,	PUNCT
admet-621	99	18	the	the	DET
admet-621	99	19	numerical	numerical	ADJ
admet-621	99	20	values	value	NOUN
admet-621	99	21	of	of	ADP
admet-621	99	22	solubility	solubility	NOUN
admet-621	99	23	of	of	ADP
admet-621	99	24	a	a	DET
admet-621	99	25	compound	compound	NOUN
admet-621	99	26	are	be	AUX
admet-621	99	27	affected	affect	VERB
admet-621	99	28	by	by	ADP
admet-621	99	29	different	different	ADJ
admet-621	99	30	factors	factor	NOUN
admet-621	99	31	.	.	PUNCT
admet-621	100	1	amount	amount	NOUN
admet-621	100	2	of	of	ADP
admet-621	100	3	excess	excess	NOUN
admet-621	100	4	solid	solid	ADJ
admet-621	100	5	and	and	CCONJ
admet-621	100	6	sedimentation	sedimentation	NOUN
admet-621	100	7	time	time	NOUN
admet-621	100	8	could	could	AUX
admet-621	100	9	have	have	VERB
admet-621	100	10	a	a	DET
admet-621	100	11	significant	significant	ADJ
admet-621	100	12	effect	effect	NOUN
admet-621	100	13	on	on	ADP
admet-621	100	14	solubility	solubility	NOUN
admet-621	100	15	values	value	NOUN
admet-621	100	16	.	.	PUNCT
admet-621	101	1	figure	figure	NOUN
admet-621	101	2	1	1	NUM
admet-621	101	3	.	.	PUNCT
admet-621	102	1	the	the	DET
admet-621	102	2	effect	effect	NOUN
admet-621	102	3	of	of	ADP
admet-621	102	4	excess	excess	ADJ
admet-621	102	5	solid	solid	ADJ
admet-621	102	6	amount	amount	NOUN
admet-621	102	7	on	on	ADP
admet-621	102	8	solubility	solubility	NOUN
admet-621	102	9	of	of	ADP
admet-621	102	10	sodium	sodium	NOUN
admet-621	102	11	phenytoin	phenytoin	NOUN
admet-621	102	12	in	in	ADP
admet-621	102	13	water	water	NOUN
admet-621	102	14	at	at	ADP
admet-621	102	15	37	37	NUM
admet-621	102	16	°	°	NOUN
admet-621	102	17	c	c	NOUN
admet-621	102	18	(	(	PUNCT
admet-621	102	19	added	add	VERB
admet-621	102	20	weight	weight	NOUN
admet-621	102	21	of	of	ADP
admet-621	102	22	drug	drug	NOUN
admet-621	102	23	associated	associate	VERB
admet-621	102	24	with	with	ADP
admet-621	102	25	each	each	PRON
admet-621	102	26	of	of	ADP
admet-621	102	27	the	the	DET
admet-621	102	28	points	point	NOUN
admet-621	102	29	in	in	ADP
admet-621	102	30	5	5	NUM
admet-621	102	31	ml	ml	NOUN
admet-621	102	32	of	of	ADP
admet-621	102	33	solution	solution	NOUN
admet-621	102	34	is	be	AUX
admet-621	102	35	450	450	NUM
admet-621	102	36	,	,	PUNCT
admet-621	102	37	500	500	NUM
admet-621	102	38	,	,	PUNCT
admet-621	102	39	750	750	NUM
admet-621	102	40	,	,	PUNCT
admet-621	102	41	1000	1000	NUM
admet-621	102	42	,	,	PUNCT
admet-621	102	43	1250	1250	NUM
admet-621	102	44	mg	mg	PROPN
admet-621	102	45	,	,	PUNCT
admet-621	102	46	respectively	respectively	ADV
admet-621	102	47	)	)	PUNCT
admet-621	102	48	.	.	PUNCT
admet-621	103	1	ali	ali	PROPN
admet-621	103	2	shayanfar	shayanfar	PROPN
admet-621	103	3	et	et	PROPN
admet-621	103	4	al	al	PROPN
admet-621	103	5	.	.	PROPN
admet-621	103	6	admet	admet	PROPN
admet-621	103	7	&	&	CCONJ
admet-621	103	8	dmpk	dmpk	PROPN
admet-621	103	9	6(4	6(4	PROPN
admet-621	103	10	)	)	PUNCT
admet-621	103	11	(	(	PUNCT
admet-621	103	12	2018	2018	NUM
admet-621	103	13	)	)	PUNCT
admet-621	103	14	269	269	NUM
admet-621	103	15	-	-	SYM
admet-621	103	16	278	278	NUM
admet-621	103	17	274	274	NUM
admet-621	103	18	figure	figure	NOUN
admet-621	103	19	2	2	NUM
admet-621	103	20	.	.	PUNCT
admet-621	104	1	the	the	DET
admet-621	104	2	effect	effect	NOUN
admet-621	104	3	of	of	ADP
admet-621	104	4	the	the	DET
admet-621	104	5	excess	excess	ADJ
admet-621	104	6	solid	solid	ADJ
admet-621	104	7	amount	amount	NOUN
admet-621	104	8	on	on	ADP
admet-621	104	9	solubility	solubility	NOUN
admet-621	104	10	of	of	ADP
admet-621	104	11	sodium	sodium	NOUN
admet-621	104	12	phenytoin	phenytoin	NOUN
admet-621	104	13	in	in	ADP
admet-621	104	14	hcl	hcl	PROPN
admet-621	104	15	0.1	0.1	NUM
admet-621	104	16	m	m	NOUN
admet-621	104	17	at	at	ADP
admet-621	104	18	3	3	NUM
admet-621	104	19	7	7	NUM
admet-621	104	20	°	°	NOUN
admet-621	104	21	c	c	NOUN
admet-621	104	22	.	.	PUNCT
admet-621	105	1	(	(	PUNCT
admet-621	105	2	added	add	VERB
admet-621	105	3	weight	weight	NOUN
admet-621	105	4	of	of	ADP
admet-621	105	5	drug	drug	NOUN
admet-621	105	6	associated	associate	VERB
admet-621	105	7	with	with	ADP
admet-621	105	8	each	each	PRON
admet-621	105	9	of	of	ADP
admet-621	105	10	the	the	DET
admet-621	105	11	points	point	NOUN
admet-621	105	12	in	in	ADP
admet-621	105	13	5	5	NUM
admet-621	105	14	ml	ml	NOUN
admet-621	105	15	of	of	ADP
admet-621	105	16	solution	solution	NOUN
admet-621	105	17	is	be	AUX
admet-621	105	18	15	15	NUM
admet-621	105	19	,	,	PUNCT
admet-621	105	20	25	25	NUM
admet-621	105	21	,	,	PUNCT
admet-621	105	22	50	50	NUM
admet-621	105	23	and	and	CCONJ
admet-621	105	24	75	75	NUM
admet-621	105	25	mg	mg	NUM
admet-621	105	26	,	,	PUNCT
admet-621	105	27	respectively	respectively	ADV
admet-621	105	28	)	)	PUNCT
admet-621	105	29	.	.	PUNCT
admet-621	106	1	figure	figure	NOUN
admet-621	106	2	3	3	NUM
admet-621	106	3	.	.	PUNCT
admet-621	107	1	the	the	DET
admet-621	107	2	effect	effect	NOUN
admet-621	107	3	of	of	ADP
admet-621	107	4	the	the	DET
admet-621	107	5	excess	excess	ADJ
admet-621	107	6	solid	solid	ADJ
admet-621	107	7	amount	amount	NOUN
admet-621	107	8	on	on	ADP
admet-621	107	9	solubility	solubility	NOUN
admet-621	107	10	of	of	ADP
admet-621	107	11	sodium	sodium	NOUN
admet-621	107	12	phenytoin	phenytoin	NOUN
admet-621	107	13	in	in	ADP
admet-621	107	14	ethanol	ethanol	NOUN
admet-621	107	15	at	at	ADP
admet-621	107	16	37	37	NUM
admet-621	107	17	°	°	NOUN
admet-621	107	18	c	c	NOUN
admet-621	107	19	.	.	PUNCT
admet-621	108	1	(	(	PUNCT
admet-621	108	2	added	add	VERB
admet-621	108	3	weight	weight	NOUN
admet-621	108	4	of	of	ADP
admet-621	108	5	drug	drug	NOUN
admet-621	108	6	associated	associate	VERB
admet-621	108	7	with	with	ADP
admet-621	108	8	each	each	PRON
admet-621	108	9	of	of	ADP
admet-621	108	10	the	the	DET
admet-621	108	11	points	point	NOUN
admet-621	108	12	in	in	ADP
admet-621	108	13	5	5	NUM
admet-621	108	14	ml	ml	NOUN
admet-621	108	15	of	of	ADP
admet-621	108	16	solution	solution	NOUN
admet-621	108	17	is	be	AUX
admet-621	108	18	125	125	NUM
admet-621	108	19	,	,	PUNCT
admet-621	108	20	150	150	NUM
admet-621	108	21	,	,	PUNCT
admet-621	108	22	175	175	NUM
admet-621	108	23	,	,	PUNCT
admet-621	108	24	200	200	NUM
admet-621	108	25	,	,	PUNCT
admet-621	108	26	225	225	NUM
admet-621	108	27	,	,	PUNCT
admet-621	108	28	350	350	NUM
admet-621	108	29	and	and	CCONJ
admet-621	108	30	450	450	NUM
admet-621	108	31	mg	mg	NUM
admet-621	108	32	,	,	PUNCT
admet-621	108	33	respectively	respectively	ADV
admet-621	108	34	)	)	PUNCT
admet-621	108	35	.	.	PUNCT
admet-621	109	1	figure	figure	VERB
admet-621	109	2	4	4	NUM
admet-621	109	3	.	.	PUNCT
admet-621	110	1	the	the	DET
admet-621	110	2	effect	effect	NOUN
admet-621	110	3	of	of	ADP
admet-621	110	4	the	the	DET
admet-621	110	5	excess	excess	ADJ
admet-621	110	6	solid	solid	ADJ
admet-621	110	7	amount	amount	NOUN
admet-621	110	8	on	on	ADP
admet-621	110	9	solubility	solubility	NOUN
admet-621	110	10	of	of	ADP
admet-621	110	11	lamotrigine	lamotrigine	NOUN
admet-621	110	12	in	in	ADP
admet-621	110	13	water	water	NOUN
admet-621	110	14	at	at	ADP
admet-621	110	15	37	37	NUM
admet-621	110	16	°	°	NOUN
admet-621	110	17	c	c	NOUN
admet-621	110	18	.	.	PUNCT
admet-621	111	1	(	(	PUNCT
admet-621	111	2	added	add	VERB
admet-621	111	3	weight	weight	NOUN
admet-621	111	4	of	of	ADP
admet-621	111	5	drug	drug	NOUN
admet-621	111	6	associated	associate	VERB
admet-621	111	7	with	with	ADP
admet-621	111	8	each	each	PRON
admet-621	111	9	of	of	ADP
admet-621	111	10	the	the	DET
admet-621	111	11	points	point	NOUN
admet-621	111	12	in	in	ADP
admet-621	111	13	5	5	NUM
admet-621	111	14	ml	ml	NOUN
admet-621	111	15	of	of	ADP
admet-621	111	16	solution	solution	NOUN
admet-621	111	17	is	be	AUX
admet-621	111	18	25	25	NUM
admet-621	111	19	,	,	PUNCT
admet-621	111	20	75	75	NUM
admet-621	111	21	,	,	PUNCT
admet-621	111	22	175	175	NUM
admet-621	111	23	,	,	PUNCT
admet-621	111	24	250	250	NUM
admet-621	111	25	,	,	PUNCT
admet-621	111	26	375	375	NUM
admet-621	111	27	,	,	PUNCT
admet-621	111	28	500	500	NUM
admet-621	111	29	mg	mg	NOUN
admet-621	111	30	,	,	PUNCT
admet-621	111	31	respectively	respectively	ADV
admet-621	111	32	)	)	PUNCT
admet-621	111	33	.	.	PUNCT
admet-621	112	1	admet	admet	PROPN
admet-621	112	2	&	&	CCONJ
admet-621	112	3	dmpk	dmpk	PROPN
admet-621	112	4	6(4	6(4	PROPN
admet-621	112	5	)	)	PUNCT
admet-621	112	6	(	(	PUNCT
admet-621	112	7	2018	2018	NUM
admet-621	112	8	)	)	PUNCT
admet-621	112	9	269	269	NUM
admet-621	112	10	-	-	SYM
admet-621	112	11	278	278	NUM
admet-621	112	12	solubility	solubility	NOUN
admet-621	112	13	of	of	ADP
admet-621	112	14	sodium	sodium	NOUN
admet-621	112	15	phenytoin	phenytoin	NOUN
admet-621	112	16	and	and	CCONJ
admet-621	112	17	lamotrigine	lamotrigine	ADJ
admet-621	112	18	doi	doi	NOUN
admet-621	112	19	:	:	PUNCT
admet-621	112	20	10.5599	10.5599	NUM
admet-621	112	21	/	/	SYM
admet-621	112	22	admet.621	admet.621	PROPN
admet-621	112	23	275	275	NUM
admet-621	112	24	figure	figure	NOUN
admet-621	112	25	5	5	NUM
admet-621	112	26	.	.	PUNCT
admet-621	113	1	the	the	DET
admet-621	113	2	effect	effect	NOUN
admet-621	113	3	of	of	ADP
admet-621	113	4	the	the	DET
admet-621	113	5	excess	excess	ADJ
admet-621	113	6	solid	solid	ADJ
admet-621	113	7	amount	amount	NOUN
admet-621	113	8	on	on	ADP
admet-621	113	9	solubility	solubility	NOUN
admet-621	113	10	of	of	ADP
admet-621	113	11	lamotrigine	lamotrigine	NOUN
admet-621	113	12	in	in	ADP
admet-621	113	13	hcl	hcl	PROPN
admet-621	113	14	(	(	PUNCT
admet-621	113	15	0.1	0.1	NUM
admet-621	113	16	m	m	NOUN
admet-621	113	17	)	)	PUNCT
admet-621	113	18	at	at	ADP
admet-621	113	19	37	37	NUM
admet-621	113	20	°	°	NOUN
admet-621	113	21	c	c	NOUN
admet-621	113	22	.	.	PUNCT
admet-621	114	1	(	(	PUNCT
admet-621	114	2	added	add	VERB
admet-621	114	3	weight	weight	NOUN
admet-621	114	4	of	of	ADP
admet-621	114	5	drug	drug	NOUN
admet-621	114	6	associated	associate	VERB
admet-621	114	7	with	with	ADP
admet-621	114	8	each	each	PRON
admet-621	114	9	of	of	ADP
admet-621	114	10	the	the	DET
admet-621	114	11	points	point	NOUN
admet-621	114	12	in	in	ADP
admet-621	114	13	5	5	NUM
admet-621	114	14	ml	ml	NOUN
admet-621	114	15	of	of	ADP
admet-621	114	16	solution	solution	NOUN
admet-621	114	17	is	be	AUX
admet-621	114	18	25	25	NUM
admet-621	114	19	,	,	PUNCT
admet-621	114	20	30	30	NUM
admet-621	114	21	,	,	PUNCT
admet-621	114	22	35	35	NUM
admet-621	114	23	,	,	PUNCT
admet-621	114	24	40	40	NUM
admet-621	114	25	,	,	PUNCT
admet-621	114	26	50	50	NUM
admet-621	114	27	and	and	CCONJ
admet-621	114	28	75	75	NUM
admet-621	114	29	mg	mg	NUM
admet-621	114	30	,	,	PUNCT
admet-621	114	31	respectively	respectively	ADV
admet-621	114	32	)	)	PUNCT
admet-621	114	33	.	.	PUNCT
admet-621	115	1	figure	figure	VERB
admet-621	115	2	6	6	NUM
admet-621	115	3	.	.	PUNCT
admet-621	116	1	the	the	DET
admet-621	116	2	effect	effect	NOUN
admet-621	116	3	of	of	ADP
admet-621	116	4	type	type	NOUN
admet-621	116	5	of	of	ADP
admet-621	116	6	stirring	stir	VERB
admet-621	116	7	on	on	ADP
admet-621	116	8	sodium	sodium	NOUN
admet-621	116	9	phenytoin	phenytoin	NOUN
admet-621	116	10	solubility	solubility	NOUN
admet-621	116	11	in	in	ADP
admet-621	116	12	water	water	NOUN
admet-621	116	13	at	at	ADP
admet-621	116	14	37	37	NUM
admet-621	116	15	°	°	NOUN
admet-621	116	16	c	c	NOUN
admet-621	116	17	.	.	PUNCT
admet-621	117	1	(	(	PUNCT
admet-621	117	2	added	add	VERB
admet-621	117	3	weight	weight	NOUN
admet-621	117	4	of	of	ADP
admet-621	117	5	drug	drug	NOUN
admet-621	117	6	associated	associate	VERB
admet-621	117	7	with	with	ADP
admet-621	117	8	each	each	PRON
admet-621	117	9	of	of	ADP
admet-621	117	10	the	the	DET
admet-621	117	11	points	point	NOUN
admet-621	117	12	in	in	ADP
admet-621	117	13	5	5	NUM
admet-621	117	14	ml	ml	NOUN
admet-621	117	15	of	of	ADP
admet-621	117	16	solution	solution	NOUN
admet-621	117	17	is	be	AUX
admet-621	117	18	450	450	NUM
admet-621	117	19	mg	mg	NOUN
admet-621	117	20	and	and	CCONJ
admet-621	117	21	1250	1250	NUM
admet-621	117	22	mg	mg	NUM
admet-621	117	23	)	)	PUNCT
admet-621	117	24	.	.	PUNCT
admet-621	118	1	figure	figure	VERB
admet-621	118	2	7	7	NUM
admet-621	118	3	.	.	PUNCT
admet-621	119	1	the	the	DET
admet-621	119	2	effect	effect	NOUN
admet-621	119	3	of	of	ADP
admet-621	119	4	sedimentation	sedimentation	NOUN
admet-621	119	5	on	on	ADP
admet-621	119	6	sodium	sodium	NOUN
admet-621	119	7	phenytoin	phenytoin	NOUN
admet-621	119	8	solubility	solubility	NOUN
admet-621	119	9	in	in	ADP
admet-621	119	10	water	water	NOUN
admet-621	119	11	at	at	ADP
admet-621	119	12	37	37	NUM
admet-621	119	13	°	°	NOUN
admet-621	119	14	c	c	NOUN
admet-621	119	15	(	(	PUNCT
admet-621	119	16	the	the	DET
admet-621	119	17	suspensions	suspension	NOUN
admet-621	119	18	were	be	AUX
admet-621	119	19	stirred	stir	VERB
admet-621	119	20	with	with	ADP
admet-621	119	21	magnetic	magnetic	ADJ
admet-621	119	22	-	-	PUNCT
admet-621	119	23	stirrer	stirrer	NOUN
admet-621	119	24	)	)	PUNCT
admet-621	119	25	.	.	PUNCT
admet-621	120	1	(	(	PUNCT
admet-621	120	2	added	add	VERB
admet-621	120	3	weight	weight	NOUN
admet-621	120	4	of	of	ADP
admet-621	120	5	drug	drug	NOUN
admet-621	120	6	associated	associate	VERB
admet-621	120	7	with	with	ADP
admet-621	120	8	each	each	PRON
admet-621	120	9	of	of	ADP
admet-621	120	10	the	the	DET
admet-621	120	11	points	point	NOUN
admet-621	120	12	in	in	ADP
admet-621	120	13	5	5	NUM
admet-621	120	14	ml	ml	NOUN
admet-621	120	15	of	of	ADP
admet-621	120	16	solution	solution	NOUN
admet-621	120	17	is	be	AUX
admet-621	120	18	450	450	NUM
admet-621	120	19	mg	mg	NOUN
admet-621	120	20	and	and	CCONJ
admet-621	120	21	1250	1250	NUM
admet-621	120	22	mg	mg	PROPN
admet-621	120	23	,	,	PUNCT
admet-621	120	24	respectively	respectively	ADV
admet-621	120	25	)	)	PUNCT
admet-621	120	26	.	.	PUNCT
admet-621	121	1	ali	ali	PROPN
admet-621	121	2	shayanfar	shayanfar	PROPN
admet-621	121	3	et	et	PROPN
admet-621	121	4	al	al	PROPN
admet-621	121	5	.	.	PROPN
admet-621	121	6	admet	admet	PROPN
admet-621	121	7	&	&	CCONJ
admet-621	121	8	dmpk	dmpk	PROPN
admet-621	121	9	6(4	6(4	PROPN
admet-621	121	10	)	)	PUNCT
admet-621	121	11	(	(	PUNCT
admet-621	121	12	2018	2018	NUM
admet-621	121	13	)	)	PUNCT
admet-621	121	14	269	269	NUM
admet-621	121	15	-	-	SYM
admet-621	121	16	278	278	NUM
admet-621	121	17	276	276	NUM
admet-621	121	18	figure	figure	NOUN
admet-621	121	19	8	8	NUM
admet-621	121	20	.	.	PUNCT
admet-621	122	1	the	the	DET
admet-621	122	2	effect	effect	NOUN
admet-621	122	3	of	of	ADP
admet-621	122	4	sedimentation	sedimentation	NOUN
admet-621	122	5	on	on	ADP
admet-621	122	6	sodium	sodium	NOUN
admet-621	122	7	phenytoin	phenytoin	NOUN
admet-621	122	8	solubility	solubility	NOUN
admet-621	122	9	in	in	ADP
admet-621	122	10	water	water	NOUN
admet-621	122	11	at	at	ADP
admet-621	122	12	37	37	NUM
admet-621	122	13	°	°	NOUN
admet-621	122	14	c	c	NOUN
admet-621	122	15	(	(	PUNCT
admet-621	122	16	the	the	DET
admet-621	122	17	amount	amount	NOUN
admet-621	122	18	of	of	ADP
admet-621	122	19	excess	excess	ADJ
admet-621	122	20	solid	solid	ADJ
admet-621	122	21	was	be	AUX
admet-621	122	22	450	450	NUM
admet-621	122	23	mg/5	mg/5	NOUN
admet-621	122	24	ml	ml	NOUN
admet-621	122	25	)	)	PUNCT
admet-621	122	26	.	.	PUNCT
admet-621	123	1	figure	figure	NOUN
admet-621	123	2	9	9	NUM
admet-621	123	3	.	.	PUNCT
admet-621	124	1	the	the	DET
admet-621	124	2	effect	effect	NOUN
admet-621	124	3	of	of	ADP
admet-621	124	4	sedimentation	sedimentation	NOUN
admet-621	124	5	on	on	ADP
admet-621	124	6	lamotrigine	lamotrigine	PROPN
admet-621	124	7	solubility	solubility	NOUN
admet-621	124	8	in	in	ADP
admet-621	124	9	water	water	NOUN
admet-621	124	10	at	at	ADP
admet-621	124	11	37	37	NUM
admet-621	124	12	°	°	NOUN
admet-621	124	13	c	c	NOUN
admet-621	124	14	(	(	PUNCT
admet-621	124	15	the	the	DET
admet-621	124	16	amount	amount	NOUN
admet-621	124	17	of	of	ADP
admet-621	124	18	excess	excess	ADJ
admet-621	124	19	solid	solid	ADJ
admet-621	124	20	was	be	AUX
admet-621	124	21	175	175	NUM
admet-621	124	22	mg/5	mg/5	NOUN
admet-621	124	23	ml	ml	NOUN
admet-621	124	24	)	)	PUNCT
admet-621	124	25	.	.	PUNCT
admet-621	125	1	conclusion	conclusion	NOUN
admet-621	125	2	solubility	solubility	NOUN
admet-621	125	3	is	be	AUX
admet-621	125	4	a	a	DET
admet-621	125	5	classic	classic	ADJ
admet-621	125	6	and	and	CCONJ
admet-621	125	7	common	common	ADJ
admet-621	125	8	physicochemical	physicochemical	ADJ
admet-621	125	9	property	property	NOUN
admet-621	125	10	of	of	ADP
admet-621	125	11	pharmaceuticals	pharmaceutical	NOUN
admet-621	125	12	;	;	PUNCT
admet-621	125	13	however	however	ADV
admet-621	125	14	,	,	PUNCT
admet-621	125	15	its	its	PRON
admet-621	125	16	values	value	NOUN
admet-621	125	17	are	be	AUX
admet-621	125	18	affected	affect	VERB
admet-621	125	19	by	by	ADP
admet-621	125	20	various	various	ADJ
admet-621	125	21	parameters	parameter	NOUN
admet-621	125	22	.	.	PUNCT
admet-621	126	1	the	the	DET
admet-621	126	2	findings	finding	NOUN
admet-621	126	3	of	of	ADP
admet-621	126	4	this	this	DET
admet-621	126	5	study	study	NOUN
admet-621	126	6	indicated	indicate	VERB
admet-621	126	7	that	that	SCONJ
admet-621	126	8	the	the	DET
admet-621	126	9	amount	amount	NOUN
admet-621	126	10	of	of	ADP
admet-621	126	11	excess	excess	NOUN
admet-621	126	12	solid	solid	ADJ
admet-621	126	13	,	,	PUNCT
admet-621	126	14	especially	especially	ADV
admet-621	126	15	in	in	ADP
admet-621	126	16	ionized	ionized	ADJ
admet-621	126	17	form	form	NOUN
admet-621	126	18	and	and	CCONJ
admet-621	126	19	sedimentation	sedimentation	NOUN
admet-621	126	20	time	time	NOUN
admet-621	126	21	after	after	ADP
admet-621	126	22	appropriate	appropriate	ADJ
admet-621	126	23	stirring	stirring	NOUN
admet-621	126	24	,	,	PUNCT
admet-621	126	25	had	have	VERB
admet-621	126	26	significant	significant	ADJ
admet-621	126	27	effects	effect	NOUN
admet-621	126	28	on	on	ADP
admet-621	126	29	the	the	DET
admet-621	126	30	obtained	obtain	VERB
admet-621	126	31	solubility	solubility	NOUN
admet-621	126	32	of	of	ADP
admet-621	126	33	sodium	sodium	NOUN
admet-621	126	34	phenytoin	phenytoin	NOUN
admet-621	126	35	and	and	CCONJ
admet-621	126	36	lamotrigine	lamotrigine	NOUN
admet-621	126	37	.	.	PUNCT
admet-621	127	1	the	the	DET
admet-621	127	2	findings	finding	NOUN
admet-621	127	3	show	show	VERB
admet-621	127	4	that	that	SCONJ
admet-621	127	5	these	these	DET
admet-621	127	6	factors	factor	NOUN
admet-621	127	7	are	be	AUX
admet-621	127	8	possible	possible	ADJ
admet-621	127	9	reasons	reason	NOUN
admet-621	127	10	for	for	ADP
admet-621	127	11	variation	variation	NOUN
admet-621	127	12	in	in	ADP
admet-621	127	13	the	the	DET
admet-621	127	14	reported	report	VERB
admet-621	127	15	solubility	solubility	NOUN
admet-621	127	16	data	datum	NOUN
admet-621	127	17	in	in	ADP
admet-621	127	18	the	the	DET
admet-621	127	19	literature	literature	NOUN
admet-621	127	20	and	and	CCONJ
admet-621	127	21	relatively	relatively	ADV
admet-621	127	22	unsuccessful	unsuccessful	ADJ
admet-621	127	23	attempts	attempt	NOUN
admet-621	127	24	to	to	PART
admet-621	127	25	develop	develop	VERB
admet-621	127	26	solubility	solubility	NOUN
admet-621	127	27	prediction	prediction	NOUN
admet-621	127	28	models	model	NOUN
admet-621	127	29	.	.	PUNCT
admet-621	128	1	it	it	PRON
admet-621	128	2	seems	seem	VERB
admet-621	128	3	that	that	SCONJ
admet-621	128	4	the	the	DET
admet-621	128	5	proper	proper	ADJ
admet-621	128	6	reporting	reporting	NOUN
admet-621	128	7	of	of	ADP
admet-621	128	8	experimental	experimental	ADJ
admet-621	128	9	details	detail	NOUN
admet-621	128	10	is	be	AUX
admet-621	128	11	necessary	necessary	ADJ
admet-621	128	12	in	in	ADP
admet-621	128	13	solubility	solubility	NOUN
admet-621	128	14	studies	study	NOUN
admet-621	128	15	.	.	PUNCT
admet-621	129	1	acknowledgements	acknowledgement	NOUN
admet-621	129	2	this	this	DET
admet-621	129	3	article	article	NOUN
admet-621	129	4	is	be	AUX
admet-621	129	5	a	a	DET
admet-621	129	6	part	part	NOUN
admet-621	129	7	of	of	ADP
admet-621	129	8	the	the	DET
admet-621	129	9	results	result	NOUN
admet-621	129	10	of	of	ADP
admet-621	129	11	s.m	s.m	PROPN
admet-621	129	12	’s	’s	PART
admet-621	129	13	pharm.d	pharm.d	PROPN
admet-621	129	14	thesis	thesis	NOUN
admet-621	129	15	no	no	PROPN
admet-621	129	16	.	.	PROPN
admet-621	129	17	85	85	NUM
admet-621	129	18	registered	register	VERB
admet-621	129	19	at	at	ADP
admet-621	129	20	faculty	faculty	NOUN
admet-621	129	21	of	of	ADP
admet-621	129	22	pharmacy	pharmacy	NOUN
admet-621	129	23	,	,	PUNCT
admet-621	129	24	tabriz	tabriz	PROPN
admet-621	129	25	university	university	PROPN
admet-621	129	26	of	of	ADP
admet-621	129	27	medical	medical	ADJ
admet-621	129	28	sciences	sciences	PROPN
admet-621	129	29	,	,	PUNCT
admet-621	129	30	tabriz	tabriz	NOUN
admet-621	129	31	,	,	PUNCT
admet-621	129	32	iran	iran	PROPN
admet-621	129	33	.	.	PUNCT
admet-621	130	1	a.s	a.s	PROPN
admet-621	130	2	.	.	PROPN
admet-621	130	3	thanks	thank	NOUN
admet-621	130	4	the	the	DET
admet-621	130	5	ministry	ministry	PROPN
admet-621	130	6	of	of	ADP
admet-621	130	7	health	health	PROPN
admet-621	130	8	and	and	CCONJ
admet-621	130	9	medical	medical	ADJ
admet-621	130	10	education	education	NOUN
admet-621	130	11	(	(	PUNCT
admet-621	130	12	grant	grant	NOUN
admet-621	130	13	for	for	ADP
admet-621	130	14	young	young	ADJ
admet-621	130	15	assistant	assistant	ADJ
admet-621	130	16	professors	professor	NOUN
admet-621	130	17	)	)	PUNCT
admet-621	130	18	,	,	PUNCT
admet-621	130	19	tehran	tehran	PROPN
admet-621	130	20	,	,	PUNCT
admet-621	130	21	iran	iran	PROPN
admet-621	130	22	,	,	PUNCT
admet-621	130	23	for	for	ADP
admet-621	130	24	financial	financial	ADJ
admet-621	130	25	support	support	NOUN
admet-621	130	26	.	.	PUNCT
admet-621	131	1	admet	admet	PROPN
admet-621	131	2	&	&	CCONJ
admet-621	131	3	dmpk	dmpk	PROPN
admet-621	131	4	6(4	6(4	PROPN
admet-621	131	5	)	)	PUNCT
admet-621	131	6	(	(	PUNCT
admet-621	131	7	2018	2018	NUM
admet-621	131	8	)	)	PUNCT
admet-621	131	9	269	269	NUM
admet-621	131	10	-	-	SYM
admet-621	131	11	278	278	NUM
admet-621	131	12	solubility	solubility	NOUN
admet-621	131	13	of	of	ADP
admet-621	131	14	sodium	sodium	NOUN
admet-621	131	15	phenytoin	phenytoin	NOUN
admet-621	131	16	and	and	CCONJ
admet-621	131	17	lamotrigine	lamotrigine	ADJ
admet-621	131	18	doi	doi	NOUN
admet-621	131	19	:	:	PUNCT
admet-621	131	20	10.5599	10.5599	NUM
admet-621	131	21	/	/	SYM
admet-621	131	22	admet.621	admet.621	PROPN
admet-621	131	23	277	277	NUM
admet-621	131	24	references	reference	NOUN
admet-621	131	25	[	[	X
admet-621	131	26	1	1	NUM
admet-621	131	27	]	]	PUNCT
admet-621	131	28	l.	l.	PROPN
admet-621	131	29	di	di	PROPN
admet-621	131	30	,	,	PUNCT
admet-621	131	31	p.v	p.v	PROPN
admet-621	131	32	.	.	PROPN
admet-621	131	33	fish	fish	NOUN
admet-621	131	34	,	,	PUNCT
admet-621	131	35	t.	t.	PROPN
admet-621	131	36	mano	mano	PROPN
admet-621	131	37	.	.	PUNCT
admet-621	132	1	bridging	bridging	NOUN
admet-621	132	2	solubility	solubility	NOUN
admet-621	132	3	between	between	ADP
admet-621	132	4	drug	drug	NOUN
admet-621	132	5	discovery	discovery	NOUN
admet-621	132	6	and	and	CCONJ
admet-621	132	7	development	development	NOUN
admet-621	132	8	.	.	PUNCT
admet-621	133	1	drug	drug	NOUN
admet-621	133	2	discov.today	discov.today	PROPN
admet-621	133	3	17	17	NUM
admet-621	133	4	(	(	PUNCT
admet-621	133	5	2012	2012	NUM
admet-621	133	6	)	)	PUNCT
admet-621	133	7	486	486	NUM
admet-621	133	8	-	-	SYM
admet-621	133	9	495	495	NUM
admet-621	133	10	.	.	PUNCT
admet-621	134	1	[	[	X
admet-621	134	2	2	2	X
admet-621	134	3	]	]	PUNCT
admet-621	134	4	f.	f.	PROPN
admet-621	134	5	martínez	martínez	PROPN
admet-621	134	6	,	,	PUNCT
admet-621	134	7	a.	a.	PROPN
admet-621	134	8	jouyban	jouyban	PROPN
admet-621	134	9	,	,	PUNCT
admet-621	134	10	w.e	w.e	PROPN
admet-621	134	11	.	.	PROPN
admet-621	134	12	acree	acree	PROPN
admet-621	134	13	.	.	PUNCT
admet-621	135	1	pharmaceuticals	pharmaceutical	NOUN
admet-621	135	2	solubility	solubility	NOUN
admet-621	135	3	is	be	AUX
admet-621	135	4	still	still	ADV
admet-621	135	5	nowadays	nowadays	ADV
admet-621	135	6	widely	widely	ADV
admet-621	135	7	studied	study	VERB
admet-621	135	8	everywhere	everywhere	ADV
admet-621	135	9	.	.	PUNCT
admet-621	136	1	pharm	pharm	PROPN
admet-621	136	2	.	.	PUNCT
admet-621	137	1	sci	sci	PROPN
admet-621	137	2	.	.	PROPN
admet-621	138	1	23	23	NUM
admet-621	138	2	(	(	PUNCT
admet-621	138	3	2017	2017	NUM
admet-621	138	4	)	)	PUNCT
admet-621	138	5	1	1	NUM
admet-621	138	6	-	-	SYM
admet-621	138	7	2	2	NUM
admet-621	138	8	.	.	PUNCT
admet-621	139	1	[	[	X
admet-621	139	2	3	3	X
admet-621	139	3	]	]	X
admet-621	139	4	a.t	a.t	PROPN
admet-621	139	5	.	.	PROPN
admet-621	139	6	florence	florence	PROPN
admet-621	139	7	,	,	PUNCT
admet-621	139	8	d.	d.	PROPN
admet-621	139	9	attwood	attwood	PROPN
admet-621	139	10	,	,	PUNCT
admet-621	139	11	physicochemical	physicochemical	ADJ
admet-621	139	12	principles	principle	NOUN
admet-621	139	13	of	of	ADP
admet-621	139	14	pharmacy	pharmacy	NOUN
admet-621	139	15	,	,	PUNCT
admet-621	139	16	pharmaceutical	pharmaceutical	NOUN
admet-621	139	17	press	press	NOUN
admet-621	139	18	,	,	PUNCT
admet-621	139	19	london	london	PROPN
admet-621	139	20	,	,	PUNCT
admet-621	139	21	2006	2006	NUM
admet-621	139	22	.	.	PUNCT
admet-621	140	1	[	[	X
admet-621	140	2	4	4	NUM
admet-621	140	3	]	]	PUNCT
admet-621	140	4	a.	a.	NOUN
admet-621	140	5	jouyban	jouyban	PROPN
admet-621	140	6	,	,	PUNCT
admet-621	140	7	m.a.a	m.a.a	NOUN
admet-621	140	8	.	.	PUNCT
admet-621	141	1	fakhree	fakhree	ADJ
admet-621	141	2	,	,	PUNCT
admet-621	141	3	experimental	experimental	ADJ
admet-621	141	4	and	and	CCONJ
admet-621	141	5	computational	computational	ADJ
admet-621	141	6	methods	method	NOUN
admet-621	141	7	pertaining	pertain	VERB
admet-621	141	8	to	to	ADP
admet-621	141	9	drug	drug	NOUN
admet-621	141	10	solubility	solubility	NOUN
admet-621	141	11	,	,	PUNCT
admet-621	141	12	in	in	ADP
admet-621	141	13	:	:	PUNCT
admet-621	141	14	w.e	w.e	PROPN
admet-621	141	15	.	.	PROPN
admet-621	141	16	acree	acree	PROPN
admet-621	141	17	,	,	PUNCT
admet-621	141	18	jr	jr	PROPN
admet-621	141	19	.	.	PUNCT
admet-621	142	1	(	(	PUNCT
admet-621	142	2	ed	ed	NOUN
admet-621	142	3	.	.	PUNCT
admet-621	142	4	)	)	PUNCT
admet-621	142	5	toxicity	toxicity	NOUN
admet-621	142	6	and	and	CCONJ
admet-621	142	7	drug	drug	NOUN
admet-621	142	8	testing	testing	NOUN
admet-621	142	9	,	,	PUNCT
admet-621	142	10	intech	intech	PROPN
admet-621	142	11	publisher	publisher	NOUN
admet-621	142	12	:	:	PUNCT
admet-621	142	13	new	new	PROPN
admet-621	142	14	york	york	PROPN
admet-621	142	15	,	,	PUNCT
admet-621	142	16	2012	2012	NUM
admet-621	142	17	.	.	PUNCT
admet-621	143	1	[	[	X
admet-621	143	2	5	5	X
admet-621	143	3	]	]	PUNCT
admet-621	143	4	j.	j.	PROPN
admet-621	143	5	alsenz	alsenz	PROPN
admet-621	143	6	,	,	PUNCT
admet-621	143	7	m.	m.	PROPN
admet-621	143	8	kansy	kansy	PROPN
admet-621	143	9	.	.	PUNCT
admet-621	144	1	high	high	ADJ
admet-621	144	2	throughput	throughput	NOUN
admet-621	144	3	solubility	solubility	NOUN
admet-621	144	4	measurement	measurement	NOUN
admet-621	144	5	in	in	ADP
admet-621	144	6	drug	drug	NOUN
admet-621	144	7	discovery	discovery	NOUN
admet-621	144	8	and	and	CCONJ
admet-621	144	9	development	development	NOUN
admet-621	144	10	.	.	PUNCT
admet-621	145	1	adv	adv	PROPN
admet-621	145	2	.	.	PUNCT
admet-621	145	3	drug	drug	PROPN
admet-621	145	4	deliv	deliv	PROPN
admet-621	145	5	.	.	PUNCT
admet-621	146	1	rev	rev	PROPN
admet-621	146	2	.	.	PROPN
admet-621	146	3	59	59	NUM
admet-621	146	4	(	(	PUNCT
admet-621	146	5	2007	2007	NUM
admet-621	146	6	)	)	PUNCT
admet-621	146	7	546	546	NUM
admet-621	146	8	-	-	SYM
admet-621	146	9	567	567	NUM
admet-621	146	10	.	.	PUNCT
admet-621	147	1	[	[	X
admet-621	147	2	6	6	NUM
admet-621	147	3	]	]	PUNCT
admet-621	147	4	a.	a.	NOUN
admet-621	147	5	jouyban	jouyban	PROPN
admet-621	147	6	.	.	PUNCT
admet-621	148	1	review	review	NOUN
admet-621	148	2	of	of	ADP
admet-621	148	3	the	the	DET
admet-621	148	4	cosolvency	cosolvency	NOUN
admet-621	148	5	models	model	NOUN
admet-621	148	6	for	for	ADP
admet-621	148	7	predicting	predict	VERB
admet-621	148	8	solubility	solubility	NOUN
admet-621	148	9	of	of	ADP
admet-621	148	10	drugs	drug	NOUN
admet-621	148	11	in	in	ADP
admet-621	148	12	water	water	NOUN
admet-621	148	13	-	-	PUNCT
admet-621	148	14	cosolvent	cosolvent	NOUN
admet-621	148	15	mixtures	mixture	NOUN
admet-621	148	16	.	.	PUNCT
admet-621	149	1	j.	j.	PROPN
admet-621	149	2	pharm	pharm	PROPN
admet-621	149	3	.	.	PUNCT
admet-621	150	1	pharm	pharm	PROPN
admet-621	150	2	.	.	PUNCT
admet-621	151	1	sci	sci	PROPN
admet-621	151	2	.	.	PROPN
admet-621	152	1	11	11	NUM
admet-621	152	2	(	(	PUNCT
admet-621	152	3	2008	2008	NUM
admet-621	152	4	)	)	PUNCT
admet-621	152	5	32	32	NUM
admet-621	152	6	-	-	SYM
admet-621	152	7	58	58	NUM
admet-621	152	8	.	.	PUNCT
admet-621	153	1	[	[	X
admet-621	153	2	7	7	NUM
admet-621	153	3	]	]	PUNCT
admet-621	153	4	a.	a.	NOUN
admet-621	153	5	avdeef	avdeef	PROPN
admet-621	153	6	,	,	PUNCT
admet-621	153	7	e.	e.	PROPN
admet-621	153	8	fuguet	fuguet	PROPN
admet-621	153	9	,	,	PUNCT
admet-621	153	10	a.	a.	PROPN
admet-621	153	11	llinàs	llinàs	PROPN
admet-621	153	12	,	,	PUNCT
admet-621	153	13	c.	c.	PROPN
admet-621	153	14	ràfols	ràfols	PROPN
admet-621	153	15	,	,	PUNCT
admet-621	153	16	e.	e.	PROPN
admet-621	153	17	bosch	bosch	PROPN
admet-621	153	18	,	,	PUNCT
admet-621	153	19	g.	g.	PROPN
admet-621	153	20	völgyi	völgyi	PROPN
admet-621	153	21	,	,	PUNCT
admet-621	153	22	t.	t.	NOUN
admet-621	153	23	verbić	verbić	PROPN
admet-621	153	24	,	,	PUNCT
admet-621	153	25	e.	e.	PROPN
admet-621	153	26	boldyreva	boldyreva	PROPN
admet-621	153	27	,	,	PUNCT
admet-621	153	28	k.	k.	PROPN
admet-621	153	29	takács	takács	PROPN
admet-621	153	30	-	-	PUNCT
admet-621	153	31	novák	novák	PROPN
admet-621	153	32	.	.	PUNCT
admet-621	154	1	equilibrium	equilibrium	NOUN
admet-621	154	2	solubility	solubility	NOUN
admet-621	154	3	measurement	measurement	NOUN
admet-621	154	4	of	of	ADP
admet-621	154	5	ionizable	ionizable	ADJ
admet-621	154	6	drugs	drug	NOUN
admet-621	154	7	–	–	PUNCT
admet-621	154	8	consensus	consensus	NOUN
admet-621	154	9	recommendations	recommendation	NOUN
admet-621	154	10	for	for	ADP
admet-621	154	11	improving	improve	VERB
admet-621	154	12	data	datum	NOUN
admet-621	154	13	quality	quality	NOUN
admet-621	154	14	.	.	PUNCT
admet-621	155	1	admet	admet	PROPN
admet-621	155	2	&	&	CCONJ
admet-621	155	3	dmpk	dmpk	PROPN
admet-621	155	4	4	4	NUM
admet-621	155	5	(	(	PUNCT
admet-621	155	6	2016	2016	NUM
admet-621	155	7	)	)	PUNCT
admet-621	155	8	117	117	NUM
admet-621	155	9	-	-	SYM
admet-621	155	10	178	178	NUM
admet-621	155	11	.	.	PUNCT
admet-621	156	1	[	[	X
admet-621	156	2	8	8	NUM
admet-621	156	3	]	]	X
admet-621	156	4	e.	e.	PROPN
admet-621	156	5	baka	baka	PROPN
admet-621	156	6	,	,	PUNCT
admet-621	156	7	j.e.a	j.e.a	PROPN
admet-621	156	8	.	.	PUNCT
admet-621	156	9	comer	comer	PROPN
admet-621	156	10	,	,	PUNCT
admet-621	156	11	k.	k.	PROPN
admet-621	156	12	takács	takács	PROPN
admet-621	156	13	-	-	PUNCT
admet-621	156	14	novák	novák	NOUN
admet-621	156	15	.	.	PUNCT
admet-621	156	16	study	study	NOUN
admet-621	156	17	of	of	ADP
admet-621	156	18	equilibrium	equilibrium	NOUN
admet-621	156	19	solubility	solubility	NOUN
admet-621	156	20	measurement	measurement	NOUN
admet-621	156	21	by	by	ADP
admet-621	156	22	saturation	saturation	NOUN
admet-621	156	23	shake	shake	NOUN
admet-621	156	24	-	-	PUNCT
admet-621	156	25	flask	flask	NOUN
admet-621	156	26	method	method	NOUN
admet-621	156	27	using	use	VERB
admet-621	156	28	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-621	156	29	as	as	ADP
admet-621	156	30	model	model	NOUN
admet-621	156	31	compound	compound	PROPN
admet-621	156	32	.	.	PUNCT
admet-621	157	1	j.	j.	PROPN
admet-621	157	2	pharm	pharm	PROPN
admet-621	157	3	.	.	PUNCT
admet-621	157	4	biomed	biome	VERB
admet-621	157	5	.	.	PUNCT
admet-621	158	1	anal	anal	ADJ
admet-621	158	2	.	.	PUNCT
admet-621	159	1	46	46	NUM
admet-621	159	2	(	(	PUNCT
admet-621	159	3	2008	2008	NUM
admet-621	159	4	)	)	PUNCT
admet-621	159	5	335	335	NUM
admet-621	159	6	-	-	SYM
admet-621	159	7	341	341	NUM
admet-621	159	8	.	.	PUNCT
admet-621	160	1	[	[	X
admet-621	160	2	9	9	NUM
admet-621	160	3	]	]	PUNCT
admet-621	160	4	a.	a.	NOUN
admet-621	160	5	shayanfar	shayanfar	PROPN
admet-621	160	6	,	,	PUNCT
admet-621	160	7	m.a.a	m.a.a	PROPN
admet-621	160	8	.	.	PUNCT
admet-621	161	1	fakhree	fakhree	PROPN
admet-621	161	2	,	,	PUNCT
admet-621	161	3	a.	a.	NOUN
admet-621	161	4	jouyban	jouyban	PROPN
admet-621	161	5	.	.	PUNCT
admet-621	162	1	a	a	DET
admet-621	162	2	simple	simple	ADJ
admet-621	162	3	qspr	qspr	NOUN
admet-621	162	4	model	model	NOUN
admet-621	162	5	to	to	PART
admet-621	162	6	predict	predict	VERB
admet-621	162	7	aqueous	aqueous	ADJ
admet-621	162	8	solubility	solubility	NOUN
admet-621	162	9	of	of	ADP
admet-621	162	10	drugs	drug	NOUN
admet-621	162	11	.	.	PUNCT
admet-621	163	1	j.	j.	PROPN
admet-621	163	2	drug	drug	PROPN
admet-621	163	3	deliv	deliv	PROPN
admet-621	163	4	.	.	PUNCT
admet-621	164	1	sci	sci	PROPN
admet-621	164	2	.	.	PROPN
admet-621	164	3	technol	technol	PROPN
admet-621	164	4	.	.	PROPN
admet-621	165	1	20	20	NUM
admet-621	165	2	(	(	PUNCT
admet-621	165	3	2010	2010	NUM
admet-621	165	4	)	)	PUNCT
admet-621	165	5	467	467	NUM
admet-621	165	6	-	-	SYM
admet-621	165	7	476	476	NUM
admet-621	165	8	.	.	PUNCT
admet-621	166	1	[	[	X
admet-621	166	2	10	10	NUM
admet-621	166	3	]	]	X
admet-621	166	4	a.	a.	NOUN
admet-621	166	5	ghanbari	ghanbari	PROPN
admet-621	166	6	,	,	PUNCT
admet-621	166	7	y.	y.	PROPN
admet-621	166	8	sarbaz	sarbaz	PROPN
admet-621	166	9	,	,	PUNCT
admet-621	166	10	v.	v.	ADP
admet-621	166	11	jouyban	jouyban	PROPN
admet-621	166	12	-	-	PUNCT
admet-621	166	13	gharamaleki	gharamaleki	PROPN
admet-621	166	14	,	,	PUNCT
admet-621	166	15	k.	k.	PROPN
admet-621	166	16	jouyban	jouyban	PROPN
admet-621	166	17	-	-	PUNCT
admet-621	166	18	gharamaleki	gharamaleki	PROPN
admet-621	166	19	,	,	PUNCT
admet-621	166	20	j.	j.	PROPN
admet-621	166	21	soleymani	soleymani	PROPN
admet-621	166	22	,	,	PUNCT
admet-621	166	23	a.	a.	NOUN
admet-621	166	24	jouyban	jouyban	PROPN
admet-621	166	25	.	.	PUNCT
admet-621	167	1	an	an	DET
admet-621	167	2	improved	improved	ADJ
admet-621	167	3	automated	automate	VERB
admet-621	167	4	setup	setup	NOUN
admet-621	167	5	for	for	ADP
admet-621	167	6	solubility	solubility	NOUN
admet-621	167	7	determination	determination	NOUN
admet-621	167	8	of	of	ADP
admet-621	167	9	drugs	drug	NOUN
admet-621	167	10	.	.	PUNCT
admet-621	168	1	pharm	pharm	NOUN
admet-621	168	2	.	.	PUNCT
admet-621	169	1	sci	sci	PROPN
admet-621	169	2	.	.	PROPN
admet-621	170	1	22	22	NUM
admet-621	170	2	(	(	PUNCT
admet-621	170	3	2016	2016	NUM
admet-621	170	4	)	)	PUNCT
admet-621	170	5	210	210	NUM
admet-621	170	6	-	-	SYM
admet-621	170	7	214	214	NUM
admet-621	170	8	.	.	PUNCT
admet-621	171	1	[	[	X
admet-621	171	2	11	11	NUM
admet-621	171	3	]	]	X
admet-621	171	4	s.b	s.b	PROPN
admet-621	171	5	.	.	PROPN
admet-621	171	6	murdande	murdande	PROPN
admet-621	171	7	,	,	PUNCT
admet-621	171	8	m.j	m.j	PROPN
admet-621	171	9	.	.	PROPN
admet-621	171	10	pikal	pikal	PROPN
admet-621	171	11	,	,	PUNCT
admet-621	171	12	r.m	r.m	PROPN
admet-621	171	13	.	.	PROPN
admet-621	171	14	shanker	shanker	PROPN
admet-621	171	15	,	,	PUNCT
admet-621	171	16	r.h	r.h	PROPN
admet-621	171	17	.	.	PROPN
admet-621	171	18	bogner	bogner	PROPN
admet-621	171	19	.	.	PUNCT
admet-621	172	1	aqueous	aqueous	ADJ
admet-621	172	2	solubility	solubility	NOUN
admet-621	172	3	of	of	ADP
admet-621	172	4	crystalline	crystalline	NOUN
admet-621	172	5	and	and	CCONJ
admet-621	172	6	amorphous	amorphous	ADJ
admet-621	172	7	drugs	drug	NOUN
admet-621	172	8	:	:	PUNCT
admet-621	172	9	challenges	challenge	NOUN
admet-621	172	10	in	in	ADP
admet-621	172	11	measurement	measurement	NOUN
admet-621	172	12	.	.	PUNCT
admet-621	173	1	pharm	pharm	PROPN
admet-621	173	2	.	.	PUNCT
admet-621	174	1	dev	dev	PROPN
admet-621	174	2	.	.	PUNCT
admet-621	174	3	technol	technol	PROPN
admet-621	174	4	.	.	PUNCT
admet-621	175	1	16	16	NUM
admet-621	175	2	(	(	PUNCT
admet-621	175	3	2011	2011	NUM
admet-621	175	4	)	)	PUNCT
admet-621	175	5	187	187	NUM
admet-621	175	6	-	-	SYM
admet-621	175	7	200	200	NUM
admet-621	175	8	.	.	PUNCT
admet-621	176	1	[	[	X
admet-621	176	2	12	12	NUM
admet-621	176	3	]	]	PUNCT
admet-621	176	4	a.	a.	NOUN
admet-621	176	5	avdeef	avdeef	PROPN
admet-621	176	6	.	.	PUNCT
admet-621	177	1	suggested	suggest	VERB
admet-621	177	2	improvements	improvement	NOUN
admet-621	177	3	for	for	ADP
admet-621	177	4	measurement	measurement	NOUN
admet-621	177	5	of	of	ADP
admet-621	177	6	equilibrium	equilibrium	NOUN
admet-621	177	7	solubility	solubility	NOUN
admet-621	177	8	-	-	PUNCT
admet-621	177	9	ph	ph	NOUN
admet-621	177	10	of	of	ADP
admet-621	177	11	ionizable	ionizable	ADJ
admet-621	177	12	drugs	drug	NOUN
admet-621	177	13	.	.	PUNCT
admet-621	178	1	admet	admet	PROPN
admet-621	178	2	&	&	CCONJ
admet-621	178	3	dmpk	dmpk	PROPN
admet-621	178	4	3	3	NUM
admet-621	178	5	(	(	PUNCT
admet-621	178	6	2015	2015	NUM
admet-621	178	7	)	)	PUNCT
admet-621	178	8	84	84	NUM
admet-621	178	9	-	-	SYM
admet-621	178	10	109	109	NUM
admet-621	178	11	.	.	PUNCT
admet-621	179	1	[	[	X
admet-621	179	2	13	13	NUM
admet-621	179	3	]	]	PUNCT
admet-621	179	4	k.	k.	PROPN
admet-621	179	5	kawakami	kawakami	PROPN
admet-621	179	6	,	,	PUNCT
admet-621	179	7	k.	k.	PROPN
admet-621	179	8	miyoshi	miyoshi	PROPN
admet-621	179	9	,	,	PUNCT
admet-621	179	10	y.	y.	PROPN
admet-621	179	11	ida	ida	PROPN
admet-621	179	12	.	.	PUNCT
admet-621	179	13	impact	impact	NOUN
admet-621	179	14	of	of	ADP
admet-621	179	15	the	the	DET
admet-621	179	16	amount	amount	NOUN
admet-621	179	17	of	of	ADP
admet-621	179	18	excess	excess	ADJ
admet-621	179	19	solids	solid	NOUN
admet-621	179	20	on	on	ADP
admet-621	179	21	apparent	apparent	ADJ
admet-621	179	22	solubility	solubility	NOUN
admet-621	179	23	.	.	PUNCT
admet-621	180	1	pharm	pharm	NOUN
admet-621	180	2	.	.	PUNCT
admet-621	181	1	res	re	NOUN
admet-621	181	2	.	.	PUNCT
admet-621	182	1	22	22	NUM
admet-621	182	2	(	(	PUNCT
admet-621	182	3	2005	2005	NUM
admet-621	182	4	)	)	PUNCT
admet-621	182	5	1537	1537	NUM
admet-621	182	6	-	-	SYM
admet-621	182	7	1543	1543	NUM
admet-621	182	8	.	.	PUNCT
admet-621	183	1	[	[	X
admet-621	183	2	14	14	NUM
admet-621	183	3	]	]	PUNCT
admet-621	183	4	z.	z.	PROPN
admet-621	183	5	wang	wang	PROPN
admet-621	183	6	,	,	PUNCT
admet-621	183	7	l.s	l.s	PROPN
admet-621	183	8	.	.	PROPN
admet-621	183	9	burrell	burrell	PROPN
admet-621	183	10	,	,	PUNCT
admet-621	183	11	w.j	w.j	PROPN
admet-621	183	12	.	.	PROPN
admet-621	183	13	lambert	lambert	PROPN
admet-621	183	14	.	.	PUNCT
admet-621	184	1	solubility	solubility	NOUN
admet-621	184	2	of	of	ADP
admet-621	184	3	e2050	e2050	PROPN
admet-621	184	4	at	at	ADP
admet-621	184	5	various	various	ADJ
admet-621	184	6	ph	ph	NOUN
admet-621	184	7	:	:	PUNCT
admet-621	184	8	a	a	DET
admet-621	184	9	case	case	NOUN
admet-621	184	10	in	in	ADP
admet-621	184	11	which	which	PRON
admet-621	184	12	apparent	apparent	ADJ
admet-621	184	13	solubility	solubility	NOUN
admet-621	184	14	is	be	AUX
admet-621	184	15	affected	affect	VERB
admet-621	184	16	by	by	ADP
admet-621	184	17	the	the	DET
admet-621	184	18	amount	amount	NOUN
admet-621	184	19	of	of	ADP
admet-621	184	20	excess	excess	ADJ
admet-621	184	21	solid	solid	ADJ
admet-621	184	22	.	.	PUNCT
admet-621	185	1	j.	j.	PROPN
admet-621	185	2	pharm	pharm	PROPN
admet-621	185	3	.	.	PUNCT
admet-621	186	1	sci	sci	PROPN
admet-621	186	2	.	.	PROPN
admet-621	187	1	91	91	NUM
admet-621	187	2	(	(	PUNCT
admet-621	187	3	2002	2002	NUM
admet-621	187	4	)	)	PUNCT
admet-621	187	5	1445	1445	NUM
admet-621	187	6	-	-	SYM
admet-621	187	7	1455	1455	NUM
admet-621	187	8	.	.	PUNCT
admet-621	188	1	[	[	X
admet-621	188	2	15	15	NUM
admet-621	188	3	]	]	PUNCT
admet-621	188	4	a.	a.	NOUN
admet-621	188	5	avdeef	avdeef	PROPN
admet-621	188	6	.	.	PUNCT
admet-621	189	1	solubility	solubility	NOUN
admet-621	189	2	of	of	ADP
admet-621	189	3	sparingly	sparingly	ADV
admet-621	189	4	-	-	PUNCT
admet-621	189	5	soluble	soluble	ADJ
admet-621	189	6	ionizable	ionizable	ADJ
admet-621	189	7	drugs	drug	NOUN
admet-621	189	8	.	.	PUNCT
admet-621	190	1	adv	adv	PROPN
admet-621	190	2	.	.	PUNCT
admet-621	190	3	drug	drug	PROPN
admet-621	190	4	deliv	deliv	PROPN
admet-621	190	5	.	.	PUNCT
admet-621	191	1	rev	rev	PROPN
admet-621	191	2	.	.	PROPN
admet-621	191	3	59	59	NUM
admet-621	191	4	(	(	PUNCT
admet-621	191	5	2007	2007	NUM
admet-621	191	6	)	)	PUNCT
admet-621	191	7	568	568	NUM
admet-621	191	8	-	-	SYM
admet-621	191	9	590	590	NUM
admet-621	191	10	.	.	PUNCT
admet-621	192	1	[	[	X
admet-621	192	2	16	16	NUM
admet-621	192	3	]	]	X
admet-621	192	4	a.c	a.c	PROPN
admet-621	192	5	.	.	PROPN
admet-621	192	6	moffat	moffat	PROPN
admet-621	192	7	,	,	PUNCT
admet-621	192	8	m.d	m.d	PROPN
admet-621	192	9	.	.	PROPN
admet-621	192	10	osselton	osselton	PROPN
admet-621	192	11	,	,	PUNCT
admet-621	192	12	b.	b.	PROPN
admet-621	192	13	widdop	widdop	PROPN
admet-621	192	14	,	,	PUNCT
admet-621	192	15	j.	j.	PROPN
admet-621	192	16	watts	watts	PROPN
admet-621	192	17	,	,	PUNCT
admet-621	192	18	clarke	clarke	PROPN
admet-621	192	19	's	's	PART
admet-621	192	20	analysis	analysis	NOUN
admet-621	192	21	of	of	ADP
admet-621	192	22	drugs	drug	NOUN
admet-621	192	23	and	and	CCONJ
admet-621	192	24	poisons	poison	NOUN
admet-621	192	25	,	,	PUNCT
admet-621	192	26	pharmaceutical	pharmaceutical	NOUN
admet-621	192	27	press	press	NOUN
admet-621	192	28	,	,	PUNCT
admet-621	192	29	london	london	PROPN
admet-621	192	30	,	,	PUNCT
admet-621	192	31	2011	2011	NUM
admet-621	192	32	.	.	PUNCT
admet-621	193	1	[	[	X
admet-621	193	2	17	17	NUM
admet-621	193	3	]	]	PUNCT
admet-621	193	4	a.	a.	NOUN
admet-621	193	5	mabhoot	mabhoot	PROPN
admet-621	193	6	,	,	PUNCT
admet-621	193	7	a.	a.	NOUN
admet-621	193	8	jouyban	jouyban	PROPN
admet-621	193	9	.	.	PUNCT
admet-621	194	1	solubility	solubility	NOUN
admet-621	194	2	of	of	ADP
admet-621	194	3	sodium	sodium	NOUN
admet-621	194	4	phenytoin	phenytoin	NOUN
admet-621	194	5	in	in	ADP
admet-621	194	6	ethanol	ethanol	NOUN
admet-621	194	7	+	+	CCONJ
admet-621	194	8	water	water	NOUN
admet-621	194	9	mixtures	mixture	NOUN
admet-621	194	10	at	at	ADP
admet-621	194	11	various	various	ADJ
admet-621	194	12	temperatures	temperature	NOUN
admet-621	194	13	.	.	PUNCT
admet-621	195	1	chem	chem	NOUN
admet-621	195	2	.	.	PUNCT
admet-621	196	1	eng	eng	PROPN
admet-621	196	2	.	.	PROPN
admet-621	197	1	technol	technol	PROPN
admet-621	197	2	.	.	PROPN
admet-621	198	1	203	203	NUM
admet-621	198	2	(	(	PUNCT
admet-621	198	3	2016	2016	NUM
admet-621	198	4	)	)	PUNCT
admet-621	198	5	1009	1009	NUM
admet-621	198	6	-	-	SYM
admet-621	198	7	1012	1012	NUM
admet-621	198	8	.	.	PUNCT
admet-621	199	1	[	[	X
admet-621	199	2	18	18	NUM
admet-621	199	3	]	]	PUNCT
admet-621	199	4	a.	a.	NOUN
admet-621	199	5	shayanfar	shayanfar	PROPN
admet-621	199	6	,	,	PUNCT
admet-621	199	7	m.a.a	m.a.a	PROPN
admet-621	199	8	.	.	PUNCT
admet-621	200	1	fakhree	fakhree	PROPN
admet-621	200	2	,	,	PUNCT
admet-621	200	3	w.e	w.e	PROPN
admet-621	200	4	.	.	PROPN
admet-621	200	5	acree	acree	PROPN
admet-621	200	6	jr	jr	PROPN
admet-621	200	7	,	,	PUNCT
admet-621	200	8	a.	a.	PROPN
admet-621	200	9	jouyban	jouyban	PROPN
admet-621	200	10	.	.	PUNCT
admet-621	201	1	solubility	solubility	NOUN
admet-621	201	2	of	of	ADP
admet-621	201	3	lamotrigine	lamotrigine	NOUN
admet-621	201	4	,	,	PUNCT
admet-621	201	5	diazepam	diazepam	NOUN
admet-621	201	6	,	,	PUNCT
admet-621	201	7	and	and	CCONJ
admet-621	201	8	clonazepam	clonazepam	NOUN
admet-621	201	9	in	in	ADP
admet-621	201	10	ethanol	ethanol	NOUN
admet-621	201	11	+	+	CCONJ
admet-621	201	12	water	water	NOUN
admet-621	201	13	mixtures	mixture	NOUN
admet-621	201	14	at	at	ADP
admet-621	201	15	298.15	298.15	NUM
admet-621	201	16	k.	k.	PROPN
admet-621	201	17	j.	j.	PROPN
admet-621	201	18	chem	chem	PROPN
admet-621	201	19	.	.	PUNCT
admet-621	202	1	eng	eng	PROPN
admet-621	202	2	.	.	PROPN
admet-621	202	3	data	data	PROPN
admet-621	202	4	54	54	NUM
admet-621	202	5	(	(	PUNCT
admet-621	202	6	2009	2009	NUM
admet-621	202	7	)	)	PUNCT
admet-621	202	8	1107	1107	NUM
admet-621	202	9	-	-	SYM
admet-621	202	10	1109	1109	NUM
admet-621	202	11	.	.	PUNCT
admet-621	203	1	[	[	X
admet-621	203	2	19	19	NUM
admet-621	203	3	]	]	PUNCT
admet-621	203	4	k.	k.	PROPN
admet-621	203	5	beattie	beattie	PROPN
admet-621	203	6	,	,	PUNCT
admet-621	203	7	g.	g.	PROPN
admet-621	203	8	phadke	phadke	PROPN
admet-621	203	9	,	,	PUNCT
admet-621	203	10	j.	j.	PROPN
admet-621	203	11	novakovic	novakovic	PROPN
admet-621	203	12	,	,	PUNCT
admet-621	203	13	chapter	chapter	NOUN
admet-621	203	14	6	6	NUM
admet-621	203	15	lamotrigine	lamotrigine	NOUN
admet-621	203	16	,	,	PUNCT
admet-621	203	17	in	in	ADP
admet-621	203	18	:	:	PUNCT
admet-621	203	19	h.g	h.g	PROPN
admet-621	203	20	.	.	PUNCT
admet-621	203	21	brittain	brittain	PROPN
admet-621	203	22	(	(	PUNCT
admet-621	203	23	ed	ed	NOUN
admet-621	203	24	.	.	PUNCT
admet-621	203	25	)	)	PUNCT
admet-621	204	1	profiles	profile	NOUN
admet-621	204	2	of	of	ADP
admet-621	204	3	drug	drug	NOUN
admet-621	204	4	substances	substance	NOUN
admet-621	204	5	,	,	PUNCT
admet-621	204	6	excipients	excipient	NOUN
admet-621	204	7	and	and	CCONJ
admet-621	204	8	related	relate	VERB
admet-621	204	9	methodology	methodology	NOUN
admet-621	204	10	,	,	PUNCT
admet-621	204	11	academic	academic	ADJ
admet-621	204	12	press	press	NOUN
admet-621	204	13	,	,	PUNCT
admet-621	204	14	2012	2012	NUM
admet-621	204	15	,	,	PUNCT
admet-621	204	16	pp	pp	ADJ
admet-621	204	17	.	.	PUNCT
admet-621	205	1	245	245	NUM
admet-621	205	2	-	-	SYM
admet-621	205	3	285	285	NUM
admet-621	205	4	.	.	PUNCT
admet-621	206	1	[	[	X
admet-621	206	2	20	20	NUM
admet-621	206	3	]	]	PUNCT
admet-621	206	4	a.	a.	NOUN
admet-621	206	5	avdeef	avdeef	PROPN
admet-621	206	6	,	,	PUNCT
admet-621	206	7	absorption	absorption	NOUN
admet-621	206	8	and	and	CCONJ
admet-621	206	9	drug	drug	NOUN
admet-621	206	10	development	development	NOUN
admet-621	206	11	:	:	PUNCT
admet-621	206	12	solubility	solubility	NOUN
admet-621	206	13	,	,	PUNCT
admet-621	206	14	permeability	permeability	NOUN
admet-621	206	15	,	,	PUNCT
admet-621	206	16	and	and	CCONJ
admet-621	206	17	charge	charge	NOUN
admet-621	206	18	state	state	NOUN
admet-621	206	19	,	,	PUNCT
admet-621	206	20	john	john	PROPN
admet-621	206	21	wiley	wiley	PROPN
admet-621	206	22	&	&	CCONJ
admet-621	206	23	sons	sons	PROPN
admet-621	206	24	,	,	PUNCT
admet-621	206	25	hoboken	hoboken	PROPN
admet-621	206	26	,	,	PUNCT
admet-621	206	27	new	new	PROPN
admet-621	206	28	jersey	jersey	PROPN
admet-621	206	29	,	,	PUNCT
admet-621	206	30	2012	2012	NUM
admet-621	206	31	.	.	PUNCT
admet-621	207	1	[	[	X
admet-621	207	2	21	21	NUM
admet-621	207	3	]	]	X
admet-621	207	4	j.t	j.t	PROPN
admet-621	207	5	.	.	PROPN
admet-621	207	6	rubino	rubino	PROPN
admet-621	207	7	.	.	PUNCT
admet-621	208	1	solubilities	solubility	NOUN
admet-621	208	2	and	and	CCONJ
admet-621	208	3	solid	solid	ADJ
admet-621	208	4	state	state	NOUN
admet-621	208	5	properties	property	NOUN
admet-621	208	6	of	of	ADP
admet-621	208	7	the	the	DET
admet-621	208	8	sodium	sodium	NOUN
admet-621	208	9	salts	salt	NOUN
admet-621	208	10	of	of	ADP
admet-621	208	11	drugs	drug	NOUN
admet-621	208	12	.	.	PUNCT
admet-621	209	1	j.	j.	PROPN
admet-621	209	2	pharm	pharm	PROPN
admet-621	209	3	.	.	PUNCT
admet-621	210	1	sci	sci	PROPN
admet-621	210	2	.	.	PROPN
admet-621	211	1	78	78	NUM
admet-621	211	2	(	(	PUNCT
admet-621	211	3	1989	1989	NUM
admet-621	211	4	)	)	PUNCT
admet-621	211	5	485	485	NUM
admet-621	211	6	-	-	SYM
admet-621	211	7	489	489	NUM
admet-621	211	8	.	.	PUNCT
admet-621	212	1	[	[	X
admet-621	212	2	22	22	NUM
admet-621	212	3	]	]	PUNCT
admet-621	212	4	m.	m.	NOUN
admet-621	212	5	mosharraf	mosharraf	NOUN
admet-621	212	6	,	,	PUNCT
admet-621	212	7	t.	t.	PROPN
admet-621	212	8	sebhatu	sebhatu	PROPN
admet-621	212	9	,	,	PUNCT
admet-621	212	10	c.	c.	PROPN
admet-621	212	11	nyström	nyström	PROPN
admet-621	212	12	.	.	PUNCT
admet-621	213	1	the	the	DET
admet-621	213	2	effects	effect	NOUN
admet-621	213	3	of	of	ADP
admet-621	213	4	disordered	disordered	ADJ
admet-621	213	5	structure	structure	NOUN
admet-621	213	6	on	on	ADP
admet-621	213	7	the	the	DET
admet-621	213	8	solubility	solubility	NOUN
admet-621	213	9	and	and	CCONJ
admet-621	213	10	dissolution	dissolution	NOUN
admet-621	213	11	rates	rate	NOUN
admet-621	213	12	of	of	ADP
admet-621	213	13	some	some	DET
admet-621	213	14	hydrophilic	hydrophilic	NOUN
admet-621	213	15	,	,	PUNCT
admet-621	213	16	sparingly	sparingly	ADV
admet-621	213	17	soluble	soluble	ADJ
admet-621	213	18	drugs	drug	NOUN
admet-621	213	19	.	.	PUNCT
admet-621	214	1	int	int	NOUN
admet-621	214	2	.	.	PUNCT
admet-621	215	1	j.	j.	PROPN
admet-621	215	2	pharm	pharm	PROPN
admet-621	215	3	.	.	PUNCT
admet-621	216	1	177	177	NUM
admet-621	216	2	(	(	PUNCT
admet-621	216	3	1999	1999	NUM
admet-621	216	4	)	)	PUNCT
admet-621	216	5	29	29	NUM
admet-621	216	6	-	-	SYM
admet-621	216	7	51	51	NUM
admet-621	216	8	.	.	PUNCT
admet-621	217	1	ali	ali	PROPN
admet-621	217	2	shayanfar	shayanfar	PROPN
admet-621	217	3	et	et	PROPN
admet-621	217	4	al	al	PROPN
admet-621	217	5	.	.	PROPN
admet-621	217	6	admet	admet	PROPN
admet-621	217	7	&	&	CCONJ
admet-621	217	8	dmpk	dmpk	PROPN
admet-621	217	9	6(4	6(4	PROPN
admet-621	217	10	)	)	PUNCT
admet-621	217	11	(	(	PUNCT
admet-621	217	12	2018	2018	NUM
admet-621	217	13	)	)	PUNCT
admet-621	217	14	269	269	NUM
admet-621	217	15	-	-	SYM
admet-621	217	16	278	278	NUM
admet-621	217	17	278	278	NUM
admet-621	218	1	[	[	X
admet-621	218	2	23	23	NUM
admet-621	218	3	]	]	X
admet-621	218	4	f.	f.	PROPN
admet-621	218	5	nielloud	nielloud	PROPN
admet-621	218	6	,	,	PUNCT
admet-621	218	7	pharmaceutical	pharmaceutical	ADJ
admet-621	218	8	emulsions	emulsion	NOUN
admet-621	218	9	and	and	CCONJ
admet-621	218	10	suspensions	suspension	NOUN
admet-621	218	11	:	:	PUNCT
admet-621	218	12	revised	revise	VERB
admet-621	218	13	and	and	CCONJ
admet-621	218	14	expanded	expand	VERB
admet-621	218	15	,	,	PUNCT
admet-621	218	16	crc	crc	NOUN
admet-621	218	17	press	press	PROPN
admet-621	218	18	,	,	PUNCT
admet-621	218	19	boca	boca	PROPN
admet-621	218	20	raton	raton	PROPN
admet-621	218	21	,	,	PUNCT
admet-621	218	22	2000	2000	NUM
admet-621	218	23	.	.	PUNCT
admet-621	219	1	[	[	X
admet-621	219	2	24	24	NUM
admet-621	219	3	]	]	PUNCT
admet-621	219	4	j.	j.	PROPN
admet-621	219	5	bevernage	bevernage	PROPN
admet-621	219	6	,	,	PUNCT
admet-621	219	7	j.	j.	PROPN
admet-621	219	8	brouwers	brouwers	PROPN
admet-621	219	9	,	,	PUNCT
admet-621	219	10	m.e	m.e	PROPN
admet-621	219	11	.	.	PROPN
admet-621	219	12	brewster	brewster	PROPN
admet-621	219	13	,	,	PUNCT
admet-621	219	14	p.	p.	NOUN
admet-621	219	15	augustijns	augustijns	NOUN
admet-621	219	16	.	.	PUNCT
admet-621	220	1	evaluation	evaluation	NOUN
admet-621	220	2	of	of	ADP
admet-621	220	3	gastrointestinal	gastrointestinal	ADJ
admet-621	220	4	drug	drug	NOUN
admet-621	220	5	supersaturation	supersaturation	NOUN
admet-621	220	6	and	and	CCONJ
admet-621	220	7	precipitation	precipitation	NOUN
admet-621	220	8	:	:	PUNCT
admet-621	220	9	strategies	strategy	NOUN
admet-621	220	10	and	and	CCONJ
admet-621	220	11	issues	issue	NOUN
admet-621	220	12	.	.	PUNCT
admet-621	221	1	int	int	NOUN
admet-621	221	2	.	.	PUNCT
admet-621	222	1	j.	j.	PROPN
admet-621	222	2	pharm	pharm	PROPN
admet-621	222	3	.	.	PUNCT
admet-621	223	1	453	453	NUM
admet-621	223	2	(	(	PUNCT
admet-621	223	3	2013	2013	NUM
admet-621	223	4	)	)	PUNCT
admet-621	223	5	25	25	NUM
admet-621	223	6	-	-	SYM
admet-621	223	7	35	35	NUM
admet-621	223	8	.	.	PUNCT
admet-621	224	1	©	©	PROPN
admet-621	224	2	2018	2018	NUM
admet-621	224	3	by	by	ADP
admet-621	224	4	the	the	DET
admet-621	224	5	authors	author	NOUN
admet-621	224	6	;	;	PUNCT
admet-621	225	1	licensee	licensee	PROPN
admet-621	225	2	iapc	iapc	PROPN
admet-621	225	3	,	,	PUNCT
admet-621	225	4	zagreb	zagreb	PROPN
admet-621	225	5	,	,	PUNCT
admet-621	225	6	croatia	croatia	PROPN
admet-621	225	7	.	.	PUNCT
admet-621	226	1	this	this	DET
admet-621	226	2	article	article	NOUN
admet-621	226	3	is	be	AUX
admet-621	226	4	an	an	DET
admet-621	226	5	open	open	ADJ
admet-621	226	6	-	-	PUNCT
admet-621	226	7	access	access	NOUN
admet-621	226	8	article	article	NOUN
admet-621	226	9	distributed	distribute	VERB
admet-621	226	10	under	under	ADP
admet-621	226	11	the	the	DET
admet-621	226	12	terms	term	NOUN
admet-621	226	13	and	and	CCONJ
admet-621	226	14	conditions	condition	NOUN
admet-621	226	15	of	of	ADP
admet-621	226	16	the	the	DET
admet-621	226	17	creative	creative	ADJ
admet-621	226	18	commons	common	NOUN
admet-621	226	19	attribution	attribution	NOUN
admet-621	226	20	license	license	NOUN
admet-621	226	21	(	(	PUNCT
admet-621	226	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-621	226	23	)	)	PUNCT
admet-621	226	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN