id	sid	tid	token	lemma	pos
admet-625	1	1	physiologically	physiologically	ADV
admet-625	1	2	-	-	PUNCT
admet-625	1	3	based	base	VERB
admet-625	1	4	pharmacokinetic	pharmacokinetic	ADJ
admet-625	1	5	simulations	simulation	NOUN
admet-625	1	6	in	in	ADP
admet-625	1	7	pharmacotherapy	pharmacotherapy	NOUN
admet-625	1	8	:	:	PUNCT
admet-625	1	9	selection	selection	NOUN
admet-625	1	10	of	of	ADP
admet-625	1	11	the	the	DET
admet-625	1	12	optimal	optimal	ADJ
admet-625	1	13	administration	administration	NOUN
admet-625	1	14	route	route	NOUN
admet-625	1	15	for	for	ADP
admet-625	1	16	exogenous	exogenous	ADJ
admet-625	1	17	melatonin	melatonin	NOUN
admet-625	1	18	doi	doi	NOUN
admet-625	1	19	:	:	PUNCT
admet-625	1	20	10.5599	10.5599	NUM
admet-625	1	21	/	/	SYM
admet-625	1	22	admet.625	admet.625	NUM
admet-625	1	23	44	44	NUM
admet-625	1	24	admet	admet	PROPN
admet-625	1	25	&	&	CCONJ
admet-625	1	26	dmpk	dmpk	PROPN
admet-625	1	27	7(1	7(1	PROPN
admet-625	1	28	)	)	PUNCT
admet-625	1	29	(	(	PUNCT
admet-625	1	30	2019	2019	NUM
admet-625	1	31	)	)	PUNCT
admet-625	1	32	44	44	NUM
admet-625	1	33	-	-	SYM
admet-625	1	34	59	59	NUM
admet-625	1	35	;	;	PUNCT
admet-625	1	36	doi	doi	NOUN
admet-625	1	37	:	:	PUNCT
admet-625	1	38	http://dx.doi.org/10.5599/admet.625	http://dx.doi.org/10.5599/admet.625	X
admet-625	1	39	open	open	ADJ
admet-625	1	40	access	access	NOUN
admet-625	1	41	:	:	PUNCT
admet-625	1	42	issn	issn	PROPN
admet-625	1	43	:	:	PUNCT
admet-625	1	44	1848	1848	NUM
admet-625	1	45	-	-	SYM
admet-625	1	46	7718	7718	NUM
admet-625	1	47	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-625	1	48	original	original	ADJ
admet-625	1	49	scientific	scientific	ADJ
admet-625	1	50	paper	paper	NOUN
admet-625	1	51	physiologically	physiologically	ADV
admet-625	1	52	-	-	PUNCT
admet-625	1	53	based	base	VERB
admet-625	1	54	pharmacokinetic	pharmacokinetic	ADJ
admet-625	1	55	simulations	simulation	NOUN
admet-625	1	56	in	in	ADP
admet-625	1	57	pharmacotherapy	pharmacotherapy	NOUN
admet-625	1	58	:	:	PUNCT
admet-625	1	59	selection	selection	NOUN
admet-625	1	60	of	of	ADP
admet-625	1	61	the	the	DET
admet-625	1	62	optimal	optimal	ADJ
admet-625	1	63	administration	administration	NOUN
admet-625	1	64	route	route	NOUN
admet-625	1	65	for	for	ADP
admet-625	1	66	exogenous	exogenous	ADJ
admet-625	1	67	melatonin	melatonin	NOUN
admet-625	1	68	adriana	adriana	PROPN
admet-625	1	69	savoca	savoca	PROPN
admet-625	1	70	,	,	PUNCT
admet-625	1	71	davide	davide	PROPN
admet-625	1	72	manca	manca	PROPN
admet-625	1	73	*	*	PROPN
admet-625	1	74	pse	pse	NOUN
admet-625	1	75	-	-	PUNCT
admet-625	1	76	lab	lab	NOUN
admet-625	1	77	,	,	PUNCT
admet-625	1	78	process	process	NOUN
admet-625	1	79	systems	system	NOUN
admet-625	1	80	engineering	engineering	NOUN
admet-625	1	81	laboratory	laboratory	NOUN
admet-625	1	82	,	,	PUNCT
admet-625	1	83	dipartimento	dipartimento	ADP
admet-625	1	84	di	di	PROPN
admet-625	1	85	chimica	chimica	PROPN
admet-625	1	86	,	,	PUNCT
admet-625	1	87	materiali	materiali	PROPN
admet-625	1	88	e	e	PROPN
admet-625	1	89	ingegneria	ingegneria	PROPN
admet-625	1	90	chimica	chimica	PROPN
admet-625	1	91	“	"	PUNCT
admet-625	1	92	giulio	giulio	PROPN
admet-625	1	93	natta	natta	PROPN
admet-625	1	94	”	"	PUNCT
admet-625	1	95	,	,	PUNCT
admet-625	1	96	politecnico	politecnico	PROPN
admet-625	1	97	di	di	X
admet-625	1	98	milano	milano	PROPN
admet-625	1	99	,	,	PUNCT
admet-625	1	100	piazza	piazza	PROPN
admet-625	1	101	leonardo	leonardo	PROPN
admet-625	1	102	da	da	PROPN
admet-625	1	103	vinci	vinci	PROPN
admet-625	1	104	32	32	NUM
admet-625	1	105	,	,	PUNCT
admet-625	1	106	20133	20133	NUM
admet-625	1	107	milano	milano	PROPN
admet-625	1	108	,	,	PUNCT
admet-625	1	109	italy	italy	PROPN
admet-625	1	110	*	*	PUNCT
admet-625	1	111	corresponding	correspond	VERB
admet-625	1	112	author	author	NOUN
admet-625	1	113	:	:	PUNCT
admet-625	1	114	e	e	NOUN
admet-625	1	115	-	-	NOUN
admet-625	1	116	mail	mail	NOUN
admet-625	1	117	:	:	PUNCT
admet-625	1	118	davide.manca@polimi.it	davide.manca@polimi.it	NOUN
admet-625	1	119	;	;	PUNCT
admet-625	1	120	tel	tel	PROPN
admet-625	1	121	.	.	PUNCT
admet-625	1	122	:	:	PUNCT
admet-625	2	1	+39	+39	PROPN
admet-625	2	2	02	02	NUM
admet-625	2	3	23993271	23993271	NUM
admet-625	2	4	;	;	PUNCT
admet-625	2	5	fax	fax	NOUN
admet-625	2	6	:	:	PUNCT
admet-625	2	7	+39	+39	PROPN
admet-625	2	8	02	02	NUM
admet-625	2	9	23993280	23993280	NUM
admet-625	2	10	received	receive	VERB
admet-625	2	11	:	:	PUNCT
admet-625	2	12	october	october	PROPN
admet-625	2	13	09	09	NUM
admet-625	2	14	,	,	PUNCT
admet-625	2	15	2018	2018	NUM
admet-625	2	16	;	;	PUNCT
admet-625	2	17	revised	revise	VERB
admet-625	2	18	:	:	PUNCT
admet-625	2	19	january	january	PROPN
admet-625	2	20	09	09	NUM
admet-625	2	21	,	,	PUNCT
admet-625	2	22	2019	2019	NUM
admet-625	2	23	;	;	PUNCT
admet-625	2	24	published	publish	VERB
admet-625	2	25	:	:	PUNCT
admet-625	2	26	february	february	PROPN
admet-625	2	27	23	23	NUM
admet-625	2	28	,	,	PUNCT
admet-625	2	29	2019	2019	NUM
admet-625	2	30	abstract	abstract	NOUN
admet-625	2	31	the	the	DET
admet-625	2	32	benefits	benefit	NOUN
admet-625	2	33	of	of	ADP
admet-625	2	34	melatonin	melatonin	NOUN
admet-625	2	35	on	on	ADP
admet-625	2	36	human	human	ADJ
admet-625	2	37	body	body	NOUN
admet-625	2	38	are	be	AUX
admet-625	2	39	drawing	draw	VERB
admet-625	2	40	increasing	increase	VERB
admet-625	2	41	attention	attention	NOUN
admet-625	2	42	from	from	ADP
admet-625	2	43	several	several	ADJ
admet-625	2	44	researchers	researcher	NOUN
admet-625	2	45	in	in	ADP
admet-625	2	46	different	different	ADJ
admet-625	2	47	fields	field	NOUN
admet-625	2	48	.	.	PUNCT
admet-625	3	1	while	while	SCONJ
admet-625	3	2	its	its	PRON
admet-625	3	3	role	role	NOUN
admet-625	3	4	as	as	ADP
admet-625	3	5	cure	cure	NOUN
admet-625	3	6	for	for	ADP
admet-625	3	7	sleep	sleep	NOUN
admet-625	3	8	disturbances	disturbance	NOUN
admet-625	3	9	(	(	PUNCT
admet-625	3	10	e.g.	e.g.	ADV
admet-625	3	11	,	,	PUNCT
admet-625	3	12	jet	jet	NOUN
admet-625	3	13	lag	lag	NOUN
admet-625	3	14	,	,	PUNCT
admet-625	3	15	insomnia	insomnia	NOUN
admet-625	3	16	)	)	PUNCT
admet-625	3	17	is	be	AUX
admet-625	3	18	well	well	ADV
admet-625	3	19	documented	document	VERB
admet-625	3	20	and	and	CCONJ
admet-625	3	21	established	establish	VERB
admet-625	3	22	,	,	PUNCT
admet-625	3	23	new	new	ADJ
admet-625	3	24	functions	function	NOUN
admet-625	3	25	in	in	ADP
admet-625	3	26	physiological	physiological	ADJ
admet-625	3	27	and	and	CCONJ
admet-625	3	28	pathophysiological	pathophysiological	ADJ
admet-625	3	29	processes	process	NOUN
admet-625	3	30	are	be	AUX
admet-625	3	31	emerging	emerge	VERB
admet-625	3	32	.	.	PUNCT
admet-625	4	1	to	to	PART
admet-625	4	2	investigate	investigate	VERB
admet-625	4	3	these	these	DET
admet-625	4	4	effects	effect	NOUN
admet-625	4	5	,	,	PUNCT
admet-625	4	6	there	there	PRON
admet-625	4	7	is	be	VERB
admet-625	4	8	need	need	NOUN
admet-625	4	9	for	for	ADP
admet-625	4	10	the	the	DET
admet-625	4	11	characterization	characterization	NOUN
admet-625	4	12	of	of	ADP
admet-625	4	13	melatonin	melatonin	NOUN
admet-625	4	14	transport	transport	NOUN
admet-625	4	15	processes	process	NOUN
admet-625	4	16	in	in	ADP
admet-625	4	17	the	the	DET
admet-625	4	18	body	body	NOUN
admet-625	4	19	and	and	CCONJ
admet-625	4	20	resulting	result	VERB
admet-625	4	21	pharmacokinetics	pharmacokinetic	NOUN
admet-625	4	22	.	.	PUNCT
admet-625	5	1	although	although	SCONJ
admet-625	5	2	recent	recent	ADJ
admet-625	5	3	works	work	NOUN
admet-625	5	4	propose	propose	VERB
admet-625	5	5	physiologically	physiologically	ADV
admet-625	5	6	-	-	PUNCT
admet-625	5	7	based	base	VERB
admet-625	5	8	pharmacokinetic	pharmacokinetic	ADJ
admet-625	5	9	modelling	modelling	NOUN
admet-625	5	10	of	of	ADP
admet-625	5	11	melatonin	melatonin	NOUN
admet-625	5	12	,	,	PUNCT
admet-625	5	13	no	no	DET
admet-625	5	14	work	work	NOUN
admet-625	5	15	has	have	AUX
admet-625	5	16	yet	yet	ADV
admet-625	5	17	highlighted	highlight	VERB
admet-625	5	18	the	the	DET
admet-625	5	19	potential	potential	NOUN
admet-625	5	20	of	of	ADP
admet-625	5	21	pbpk	pbpk	NOUN
admet-625	5	22	simulations	simulation	NOUN
admet-625	5	23	to	to	PART
admet-625	5	24	shed	shed	VERB
admet-625	5	25	light	light	NOUN
admet-625	5	26	on	on	ADP
admet-625	5	27	melatonin	melatonin	NOUN
admet-625	5	28	pharmacokinetic	pharmacokinetic	ADJ
admet-625	5	29	aspects	aspect	NOUN
admet-625	5	30	and	and	CCONJ
admet-625	5	31	discrimination	discrimination	NOUN
admet-625	5	32	among	among	ADP
admet-625	5	33	administration	administration	NOUN
admet-625	5	34	routes	route	NOUN
admet-625	5	35	.	.	PUNCT
admet-625	6	1	this	this	DET
admet-625	6	2	paper	paper	NOUN
admet-625	6	3	presents	present	NOUN
admet-625	6	4	,	,	PUNCT
admet-625	6	5	validates	validate	VERB
admet-625	6	6	,	,	PUNCT
admet-625	6	7	and	and	CCONJ
admet-625	6	8	discusses	discuss	VERB
admet-625	6	9	a	a	DET
admet-625	6	10	versatile	versatile	ADJ
admet-625	6	11	pbpk	pbpk	ADJ
admet-625	6	12	model	model	NOUN
admet-625	6	13	featuring	feature	VERB
admet-625	6	14	different	different	ADJ
admet-625	6	15	ways	way	NOUN
admet-625	6	16	of	of	ADP
admet-625	6	17	administration	administration	NOUN
admet-625	6	18	and	and	CCONJ
admet-625	6	19	compares	compare	VERB
admet-625	6	20	the	the	DET
admet-625	6	21	resulting	result	VERB
admet-625	6	22	pharmacokinetic	pharmacokinetic	ADJ
admet-625	6	23	profiles	profile	NOUN
admet-625	6	24	of	of	ADP
admet-625	6	25	intravenous	intravenous	ADJ
admet-625	6	26	,	,	PUNCT
admet-625	6	27	oral	oral	ADJ
admet-625	6	28	,	,	PUNCT
admet-625	6	29	and	and	CCONJ
admet-625	6	30	transdermal	transdermal	ADJ
admet-625	6	31	administration	administration	NOUN
admet-625	6	32	,	,	PUNCT
admet-625	6	33	with	with	ADP
admet-625	6	34	the	the	DET
admet-625	6	35	goal	goal	NOUN
admet-625	6	36	of	of	ADP
admet-625	6	37	understanding	understanding	NOUN
admet-625	6	38	which	which	PRON
admet-625	6	39	is	be	AUX
admet-625	6	40	the	the	DET
admet-625	6	41	optimal	optimal	ADJ
admet-625	6	42	route	route	NOUN
admet-625	6	43	to	to	PART
admet-625	6	44	achieve	achieve	VERB
admet-625	6	45	either	either	CCONJ
admet-625	6	46	physiological	physiological	ADJ
admet-625	6	47	and/or	and/or	CCONJ
admet-625	6	48	supraphysiological	supraphysiological	ADJ
admet-625	6	49	melatonin	melatonin	NOUN
admet-625	6	50	levels	level	NOUN
admet-625	6	51	.	.	PUNCT
admet-625	7	1	keywords	keyword	NOUN
admet-625	7	2	melatonin	melatonin	NOUN
admet-625	7	3	;	;	PUNCT
admet-625	7	4	pbpk	pbpk	NOUN
admet-625	7	5	;	;	PUNCT
admet-625	7	6	administration	administration	NOUN
admet-625	7	7	route	route	NOUN
admet-625	7	8	;	;	PUNCT
admet-625	8	1	transdermal	transdermal	ADJ
admet-625	8	2	;	;	PUNCT
admet-625	8	3	controlled	control	VERB
admet-625	8	4	release	release	NOUN
admet-625	8	5	;	;	PUNCT
admet-625	8	6	simulation	simulation	NOUN
admet-625	8	7	;	;	PUNCT
admet-625	8	8	clinical	clinical	ADJ
admet-625	8	9	efficacy	efficacy	NOUN
admet-625	8	10	.	.	PUNCT
admet-625	9	1	introduction	introduction	NOUN
admet-625	9	2	in	in	ADP
admet-625	9	3	recent	recent	ADJ
admet-625	9	4	years	year	NOUN
admet-625	9	5	,	,	PUNCT
admet-625	9	6	physiologically	physiologically	ADV
admet-625	9	7	-	-	PUNCT
admet-625	9	8	based	base	VERB
admet-625	9	9	pharmacokinetic	pharmacokinetic	ADJ
admet-625	9	10	(	(	PUNCT
admet-625	9	11	pbpk	pbpk	NOUN
admet-625	9	12	)	)	PUNCT
admet-625	9	13	models	model	NOUN
admet-625	9	14	have	have	AUX
admet-625	9	15	become	become	VERB
admet-625	9	16	widely	widely	ADV
admet-625	9	17	-	-	PUNCT
admet-625	9	18	used	use	VERB
admet-625	9	19	and	and	CCONJ
admet-625	9	20	accepted	accept	VERB
admet-625	9	21	tools	tool	NOUN
admet-625	9	22	to	to	PART
admet-625	9	23	study	study	VERB
admet-625	9	24	,	,	PUNCT
admet-625	9	25	simulate	simulate	VERB
admet-625	9	26	,	,	PUNCT
admet-625	9	27	and	and	CCONJ
admet-625	9	28	predict	predict	VERB
admet-625	9	29	drugs	drug	NOUN
admet-625	9	30	concentration	concentration	NOUN
admet-625	9	31	in	in	ADP
admet-625	9	32	the	the	DET
admet-625	9	33	body	body	NOUN
admet-625	9	34	as	as	ADV
admet-625	9	35	well	well	ADV
admet-625	9	36	as	as	ADP
admet-625	9	37	provide	provide	VERB
admet-625	9	38	insight	insight	NOUN
admet-625	9	39	on	on	ADP
admet-625	9	40	their	their	PRON
admet-625	9	41	pharmacological	pharmacological	ADJ
admet-625	9	42	effects	effect	NOUN
admet-625	9	43	via	via	ADP
admet-625	9	44	combination	combination	NOUN
admet-625	9	45	with	with	ADP
admet-625	9	46	pharmacodynamic	pharmacodynamic	ADJ
admet-625	9	47	models	model	NOUN
admet-625	9	48	.	.	PUNCT
admet-625	10	1	pbpk	pbpk	NOUN
admet-625	10	2	models	model	NOUN
admet-625	10	3	are	be	AUX
admet-625	10	4	currently	currently	ADV
admet-625	10	5	applied	apply	VERB
admet-625	10	6	throughout	throughout	ADP
admet-625	10	7	the	the	DET
admet-625	10	8	phases	phase	NOUN
admet-625	10	9	of	of	ADP
admet-625	10	10	drug	drug	NOUN
admet-625	10	11	discovery	discovery	NOUN
admet-625	10	12	and	and	CCONJ
admet-625	10	13	development	development	NOUN
admet-625	10	14	with	with	ADP
admet-625	10	15	various	various	ADJ
admet-625	10	16	goals	goal	NOUN
admet-625	10	17	,	,	PUNCT
admet-625	10	18	e.g.	e.g.	ADV
admet-625	10	19	,	,	PUNCT
admet-625	10	20	inter	inter	ADJ
admet-625	10	21	-	-	ADJ
admet-625	10	22	species	species	ADJ
admet-625	10	23	extrapolation	extrapolation	NOUN
admet-625	10	24	,	,	PUNCT
admet-625	10	25	analysis	analysis	NOUN
admet-625	10	26	of	of	ADP
admet-625	10	27	chemical	chemical	NOUN
admet-625	10	28	toxicity	toxicity	NOUN
admet-625	10	29	or	or	CCONJ
admet-625	10	30	efficiency	efficiency	NOUN
admet-625	10	31	,	,	PUNCT
admet-625	10	32	investigation	investigation	NOUN
admet-625	10	33	of	of	ADP
admet-625	10	34	different	different	ADJ
admet-625	10	35	routes	route	NOUN
admet-625	10	36	of	of	ADP
admet-625	10	37	administration	administration	NOUN
admet-625	10	38	,	,	PUNCT
admet-625	10	39	and	and	CCONJ
admet-625	10	40	study	study	NOUN
admet-625	10	41	of	of	ADP
admet-625	10	42	inter	inter	ADJ
admet-625	10	43	-	-	ADJ
admet-625	10	44	individual	individual	ADJ
admet-625	10	45	variability	variability	NOUN
admet-625	10	46	[	[	X
admet-625	10	47	1	1	NUM
admet-625	10	48	-	-	SYM
admet-625	10	49	5	5	NUM
admet-625	10	50	]	]	PUNCT
admet-625	10	51	.	.	PUNCT
admet-625	11	1	indeed	indeed	ADV
admet-625	11	2	,	,	PUNCT
admet-625	11	3	pbpk	pbpk	NOUN
admet-625	11	4	simulations	simulation	NOUN
admet-625	11	5	are	be	AUX
admet-625	11	6	extremely	extremely	ADV
admet-625	11	7	useful	useful	ADJ
admet-625	11	8	to	to	PART
admet-625	11	9	study	study	VERB
admet-625	11	10	the	the	DET
admet-625	11	11	pharmacokinetic	pharmacokinetic	ADJ
admet-625	11	12	differences	difference	NOUN
admet-625	11	13	among	among	ADP
admet-625	11	14	individuals	individual	NOUN
admet-625	11	15	,	,	PUNCT
admet-625	11	16	from	from	ADP
admet-625	11	17	pediatric	pediatric	ADJ
admet-625	11	18	patients	patient	NOUN
admet-625	11	19	[	[	X
admet-625	11	20	6	6	X
admet-625	11	21	]	]	PUNCT
admet-625	11	22	to	to	ADP
admet-625	11	23	healthy	healthy	ADJ
admet-625	11	24	adults	adult	NOUN
admet-625	11	25	to	to	ADP
admet-625	11	26	special	special	ADJ
admet-625	11	27	subjects	subject	NOUN
admet-625	11	28	,	,	PUNCT
admet-625	11	29	with	with	ADP
admet-625	11	30	particular	particular	ADJ
admet-625	11	31	conditions	condition	NOUN
admet-625	11	32	(	(	PUNCT
admet-625	11	33	e.g.	e.g.	ADV
admet-625	11	34	,	,	PUNCT
admet-625	11	35	pregnancy	pregnancy	NOUN
admet-625	11	36	[	[	X
admet-625	11	37	7	7	NUM
admet-625	11	38	]	]	PUNCT
admet-625	11	39	)	)	PUNCT
admet-625	11	40	or	or	CCONJ
admet-625	11	41	specific	specific	ADJ
admet-625	11	42	diseases	disease	NOUN
admet-625	11	43	with	with	ADP
admet-625	11	44	high	high	ADJ
admet-625	11	45	probability	probability	NOUN
admet-625	11	46	of	of	ADP
admet-625	11	47	affecting	affect	VERB
admet-625	11	48	drugs	drug	NOUN
admet-625	11	49	pharmacokinetics	pharmacokinetic	NOUN
admet-625	11	50	(	(	PUNCT
admet-625	11	51	e.g.	e.g.	ADV
admet-625	11	52	,	,	PUNCT
admet-625	11	53	renal	renal	ADJ
admet-625	11	54	insufficiency	insufficiency	NOUN
admet-625	11	55	or	or	CCONJ
admet-625	11	56	liver	liver	NOUN
admet-625	11	57	diseases	disease	NOUN
admet-625	11	58	)	)	PUNCT
admet-625	11	59	.	.	PUNCT
admet-625	12	1	the	the	DET
admet-625	12	2	reason	reason	NOUN
admet-625	12	3	is	be	AUX
admet-625	12	4	that	that	SCONJ
admet-625	12	5	pbpk	pbpk	NOUN
admet-625	12	6	models	model	NOUN
admet-625	12	7	(	(	PUNCT
admet-625	12	8	first	first	ADV
admet-625	12	9	theorized	theorize	VERB
admet-625	12	10	in	in	ADP
admet-625	12	11	1937	1937	NUM
admet-625	12	12	by	by	ADP
admet-625	12	13	teorell	teorell	NOUN
admet-625	12	14	[	[	X
admet-625	12	15	8	8	NUM
admet-625	12	16	]	]	PUNCT
admet-625	12	17	)	)	PUNCT
admet-625	12	18	incorporate	incorporate	VERB
admet-625	12	19	the	the	DET
admet-625	12	20	anatomy	anatomy	NOUN
admet-625	12	21	and	and	CCONJ
admet-625	12	22	physiology	physiology	NOUN
admet-625	12	23	of	of	ADP
admet-625	12	24	the	the	DET
admet-625	12	25	patients	patient	NOUN
admet-625	12	26	’	'	PUNCT
admet-625	12	27	body	body	NOUN
admet-625	12	28	into	into	ADP
admet-625	12	29	the	the	DET
admet-625	12	30	mathematical	mathematical	ADJ
admet-625	12	31	description	description	NOUN
admet-625	12	32	of	of	ADP
admet-625	12	33	drugs	drug	NOUN
admet-625	12	34	absorption	absorption	NOUN
admet-625	12	35	,	,	PUNCT
admet-625	12	36	distribution	distribution	NOUN
admet-625	12	37	,	,	PUNCT
admet-625	12	38	metabolism	metabolism	NOUN
admet-625	12	39	,	,	PUNCT
admet-625	12	40	and	and	CCONJ
admet-625	12	41	elimination	elimination	NOUN
admet-625	12	42	(	(	PUNCT
admet-625	12	43	adme	adme	NOUN
admet-625	12	44	)	)	PUNCT
admet-625	12	45	processes	process	NOUN
admet-625	12	46	.	.	PUNCT
admet-625	13	1	their	their	PRON
admet-625	13	2	recent	recent	ADJ
admet-625	13	3	success	success	NOUN
admet-625	13	4	is	be	AUX
admet-625	13	5	also	also	ADV
admet-625	13	6	related	relate	VERB
admet-625	13	7	to	to	ADP
admet-625	13	8	the	the	DET
admet-625	13	9	current	current	ADJ
admet-625	13	10	availability	availability	NOUN
admet-625	13	11	of	of	ADP
admet-625	13	12	modern	modern	ADJ
admet-625	13	13	tools	tool	NOUN
admet-625	13	14	to	to	PART
admet-625	13	15	solve	solve	VERB
admet-625	13	16	complex	complex	ADJ
admet-625	13	17	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-625	13	18	mailto:davide.manca@polimi.it	mailto:davide.manca@polimi.it	PROPN
admet-625	13	19	admet	admet	PROPN
admet-625	13	20	&	&	CCONJ
admet-625	13	21	dmpk	dmpk	PROPN
admet-625	13	22	7(1	7(1	PROPN
admet-625	13	23	)	)	PUNCT
admet-625	13	24	(	(	PUNCT
admet-625	13	25	2019	2019	NUM
admet-625	13	26	)	)	PUNCT
admet-625	13	27	44	44	NUM
admet-625	13	28	-	-	SYM
admet-625	13	29	59	59	NUM
admet-625	13	30	pbpk	pbpk	ADJ
admet-625	13	31	simulation	simulation	NOUN
admet-625	13	32	in	in	ADP
admet-625	13	33	pharmacotherapy	pharmacotherapy	NOUN
admet-625	13	34	doi	doi	NOUN
admet-625	13	35	:	:	PUNCT
admet-625	13	36	10.5599	10.5599	NUM
admet-625	13	37	/	/	SYM
admet-625	13	38	admet.625	admet.625	NUM
admet-625	13	39	45	45	NUM
admet-625	13	40	mathematical	mathematical	ADJ
admet-625	13	41	problems	problem	NOUN
admet-625	13	42	,	,	PUNCT
admet-625	13	43	such	such	ADJ
admet-625	13	44	as	as	ADP
admet-625	13	45	systems	system	NOUN
admet-625	13	46	of	of	ADP
admet-625	13	47	ordinary	ordinary	ADJ
admet-625	13	48	differential	differential	ADJ
admet-625	13	49	equations	equation	NOUN
admet-625	13	50	(	(	PUNCT
admet-625	13	51	odes	ode	NOUN
admet-625	13	52	)	)	PUNCT
admet-625	13	53	with	with	ADP
admet-625	13	54	a	a	DET
admet-625	13	55	large	large	ADJ
admet-625	13	56	number	number	NOUN
admet-625	13	57	of	of	ADP
admet-625	13	58	parameters	parameter	NOUN
admet-625	13	59	.	.	PUNCT
admet-625	14	1	in	in	ADP
admet-625	14	2	silico	silico	NOUN
admet-625	14	3	simulations	simulation	NOUN
admet-625	14	4	are	be	AUX
admet-625	14	5	appealing	appeal	VERB
admet-625	14	6	because	because	SCONJ
admet-625	14	7	of	of	ADP
admet-625	14	8	the	the	DET
admet-625	14	9	possibility	possibility	NOUN
admet-625	14	10	to	to	PART
admet-625	14	11	carry	carry	VERB
admet-625	14	12	out	out	ADP
admet-625	14	13	“	"	PUNCT
admet-625	14	14	free	free	ADJ
admet-625	14	15	”	"	PUNCT
admet-625	14	16	and	and	CCONJ
admet-625	14	17	fast	fast	ADJ
admet-625	14	18	experiments	experiment	NOUN
admet-625	14	19	[	[	X
admet-625	14	20	9	9	NUM
admet-625	14	21	]	]	PUNCT
admet-625	14	22	,	,	PUNCT
admet-625	14	23	compared	compare	VERB
admet-625	14	24	to	to	ADP
admet-625	14	25	the	the	DET
admet-625	14	26	actual	actual	ADJ
admet-625	14	27	clinical	clinical	ADJ
admet-625	14	28	trials	trial	NOUN
admet-625	14	29	,	,	PUNCT
admet-625	14	30	whose	whose	DET
admet-625	14	31	costs	cost	NOUN
admet-625	14	32	and	and	CCONJ
admet-625	14	33	duration	duration	NOUN
admet-625	14	34	have	have	AUX
admet-625	14	35	increased	increase	VERB
admet-625	14	36	over	over	ADP
admet-625	14	37	the	the	DET
admet-625	14	38	past	past	ADJ
admet-625	14	39	20	20	NUM
admet-625	14	40	years	year	NOUN
admet-625	14	41	[	[	X
admet-625	14	42	10	10	NUM
admet-625	14	43	]	]	PUNCT
admet-625	14	44	.	.	PUNCT
admet-625	15	1	not	not	PART
admet-625	15	2	only	only	ADV
admet-625	15	3	drug	drug	NOUN
admet-625	15	4	discovery	discovery	NOUN
admet-625	15	5	and	and	CCONJ
admet-625	15	6	development	development	NOUN
admet-625	15	7	[	[	X
admet-625	15	8	11	11	NUM
admet-625	15	9	]	]	PUNCT
admet-625	15	10	,	,	PUNCT
admet-625	15	11	but	but	CCONJ
admet-625	15	12	also	also	ADV
admet-625	15	13	the	the	DET
admet-625	15	14	clinical	clinical	ADJ
admet-625	15	15	practice	practice	NOUN
admet-625	15	16	may	may	AUX
admet-625	15	17	take	take	VERB
admet-625	15	18	advantage	advantage	NOUN
admet-625	15	19	from	from	ADP
admet-625	15	20	simulation	simulation	NOUN
admet-625	15	21	via	via	ADP
admet-625	15	22	pbpk	pbpk	NOUN
admet-625	15	23	models	model	NOUN
admet-625	15	24	,	,	PUNCT
admet-625	15	25	as	as	SCONJ
admet-625	15	26	it	it	PRON
admet-625	15	27	tackles	tackle	VERB
admet-625	15	28	the	the	DET
admet-625	15	29	problem	problem	NOUN
admet-625	15	30	of	of	ADP
admet-625	15	31	selecting	select	VERB
admet-625	15	32	the	the	DET
admet-625	15	33	optimal	optimal	ADJ
admet-625	15	34	dose	dose	NOUN
admet-625	15	35	that	that	PRON
admet-625	15	36	maximizes	maximize	VERB
admet-625	15	37	therapeutic	therapeutic	ADJ
admet-625	15	38	efficacy	efficacy	NOUN
admet-625	15	39	while	while	SCONJ
admet-625	15	40	minimizing	minimize	VERB
admet-625	15	41	adverse	adverse	ADJ
admet-625	15	42	effects	effect	NOUN
admet-625	15	43	.	.	PUNCT
admet-625	16	1	on	on	ADP
admet-625	16	2	one	one	NUM
admet-625	16	3	hand	hand	NOUN
admet-625	16	4	,	,	PUNCT
admet-625	16	5	inter	inter	ADJ
admet-625	16	6	-	-	ADJ
admet-625	16	7	individual	individual	ADJ
admet-625	16	8	variability	variability	NOUN
admet-625	16	9	and	and	CCONJ
admet-625	16	10	medication	medication	NOUN
admet-625	16	11	errors	error	NOUN
admet-625	16	12	are	be	AUX
admet-625	16	13	significant	significant	ADJ
admet-625	16	14	obstacles	obstacle	NOUN
admet-625	16	15	in	in	ADP
admet-625	16	16	this	this	DET
admet-625	16	17	decision	decision	NOUN
admet-625	16	18	,	,	PUNCT
admet-625	16	19	on	on	ADP
admet-625	16	20	the	the	DET
admet-625	16	21	other	other	ADJ
admet-625	16	22	hand	hand	NOUN
admet-625	16	23	,	,	PUNCT
admet-625	16	24	the	the	DET
admet-625	16	25	choice	choice	NOUN
admet-625	16	26	of	of	ADP
admet-625	16	27	the	the	DET
admet-625	16	28	optimal	optimal	ADJ
admet-625	16	29	administration	administration	NOUN
admet-625	16	30	route	route	NOUN
admet-625	16	31	and	and	CCONJ
admet-625	16	32	dosing	dose	VERB
admet-625	16	33	regimen	regiman	NOUN
admet-625	16	34	are	be	AUX
admet-625	16	35	crucial	crucial	ADJ
admet-625	16	36	degrees	degree	NOUN
admet-625	16	37	of	of	ADP
admet-625	16	38	freedom	freedom	NOUN
admet-625	16	39	of	of	ADP
admet-625	16	40	this	this	DET
admet-625	16	41	problem	problem	NOUN
admet-625	16	42	.	.	PUNCT
admet-625	17	1	in	in	ADP
admet-625	17	2	this	this	DET
admet-625	17	3	respect	respect	NOUN
admet-625	17	4	,	,	PUNCT
admet-625	17	5	melatonin	melatonin	NOUN
admet-625	17	6	is	be	AUX
admet-625	17	7	a	a	DET
admet-625	17	8	useful	useful	ADJ
admet-625	17	9	and	and	CCONJ
admet-625	17	10	interesting	interesting	ADJ
admet-625	17	11	case	case	NOUN
admet-625	17	12	-	-	PUNCT
admet-625	17	13	study	study	NOUN
admet-625	17	14	.	.	PUNCT
admet-625	18	1	the	the	DET
admet-625	18	2	pleiotropic	pleiotropic	ADJ
admet-625	18	3	functions	function	NOUN
admet-625	18	4	of	of	ADP
admet-625	18	5	melatonin	melatonin	NOUN
admet-625	18	6	in	in	ADP
admet-625	18	7	the	the	DET
admet-625	18	8	human	human	ADJ
admet-625	18	9	body	body	NOUN
admet-625	18	10	are	be	AUX
admet-625	18	11	catalyzing	catalyze	VERB
admet-625	18	12	the	the	DET
admet-625	18	13	attention	attention	NOUN
admet-625	18	14	of	of	ADP
admet-625	18	15	several	several	ADJ
admet-625	18	16	researchers	researcher	NOUN
admet-625	18	17	in	in	ADP
admet-625	18	18	different	different	ADJ
admet-625	18	19	fields	field	NOUN
admet-625	18	20	,	,	PUNCT
admet-625	18	21	and	and	CCONJ
admet-625	18	22	its	its	PRON
admet-625	18	23	exogenous	exogenous	ADJ
admet-625	18	24	administration	administration	NOUN
admet-625	18	25	can	can	AUX
admet-625	18	26	follow	follow	VERB
admet-625	18	27	different	different	ADJ
admet-625	18	28	pathways	pathway	NOUN
admet-625	18	29	.	.	PUNCT
admet-625	19	1	although	although	SCONJ
admet-625	19	2	melatonin	melatonin	NOUN
admet-625	19	3	is	be	AUX
admet-625	19	4	particularly	particularly	ADV
admet-625	19	5	popular	popular	ADJ
admet-625	19	6	as	as	ADP
admet-625	19	7	a	a	DET
admet-625	19	8	cure	cure	NOUN
admet-625	19	9	for	for	ADP
admet-625	19	10	sleep	sleep	NOUN
admet-625	19	11	disturbances	disturbance	NOUN
admet-625	19	12	(	(	PUNCT
admet-625	19	13	i.e.	i.e.	X
admet-625	19	14	jet	jet	NOUN
admet-625	19	15	-	-	PUNCT
admet-625	19	16	lag	lag	NOUN
admet-625	19	17	,	,	PUNCT
admet-625	19	18	insomnia	insomnia	NOUN
admet-625	19	19	)	)	PUNCT
admet-625	19	20	,	,	PUNCT
admet-625	19	21	a	a	DET
admet-625	19	22	number	number	NOUN
admet-625	19	23	of	of	ADP
admet-625	19	24	other	other	ADJ
admet-625	19	25	physiological	physiological	ADJ
admet-625	19	26	and	and	CCONJ
admet-625	19	27	pathophysiological	pathophysiological	ADJ
admet-625	19	28	functions	function	NOUN
admet-625	19	29	have	have	AUX
admet-625	19	30	been	be	AUX
admet-625	19	31	investigated	investigate	VERB
admet-625	19	32	and	and	CCONJ
admet-625	19	33	are	be	AUX
admet-625	19	34	still	still	ADV
admet-625	19	35	emerging	emerge	VERB
admet-625	19	36	.	.	PUNCT
admet-625	20	1	for	for	ADP
admet-625	20	2	instance	instance	NOUN
admet-625	20	3	,	,	PUNCT
admet-625	20	4	receptor	receptor	NOUN
admet-625	20	5	-	-	PUNCT
admet-625	20	6	mediated	mediate	VERB
admet-625	20	7	actions	action	NOUN
admet-625	20	8	include	include	VERB
admet-625	20	9	regulatory	regulatory	ADJ
admet-625	20	10	functions	function	NOUN
admet-625	20	11	,	,	PUNCT
admet-625	20	12	e.g.	e.g.	ADV
admet-625	20	13	,	,	PUNCT
admet-625	20	14	immune	immune	ADJ
admet-625	20	15	response	response	NOUN
admet-625	20	16	,	,	PUNCT
admet-625	20	17	homeostasis	homeostasis	NOUN
admet-625	20	18	,	,	PUNCT
admet-625	20	19	and	and	CCONJ
admet-625	20	20	blood	blood	NOUN
admet-625	20	21	pressure	pressure	NOUN
admet-625	20	22	regulation	regulation	NOUN
admet-625	20	23	[	[	X
admet-625	20	24	12	12	NUM
admet-625	20	25	-	-	SYM
admet-625	20	26	16	16	NUM
admet-625	20	27	]	]	PUNCT
admet-625	20	28	.	.	PUNCT
admet-625	21	1	indeed	indeed	ADV
admet-625	21	2	,	,	PUNCT
admet-625	21	3	melatonin	melatonin	NOUN
admet-625	21	4	receptors	receptor	NOUN
admet-625	21	5	are	be	AUX
admet-625	21	6	distributed	distribute	VERB
admet-625	21	7	in	in	ADP
admet-625	21	8	the	the	DET
admet-625	21	9	whole	whole	ADJ
admet-625	21	10	body	body	NOUN
admet-625	21	11	.	.	PUNCT
admet-625	22	1	besides	besides	SCONJ
admet-625	22	2	,	,	PUNCT
admet-625	22	3	non	non	ADJ
admet-625	22	4	-	-	ADJ
admet-625	22	5	receptor	receptor	ADJ
admet-625	22	6	mediated	mediate	VERB
admet-625	22	7	actions	action	NOUN
admet-625	22	8	are	be	AUX
admet-625	22	9	of	of	ADP
admet-625	22	10	great	great	ADJ
admet-625	22	11	interest	interest	NOUN
admet-625	22	12	,	,	PUNCT
admet-625	22	13	especially	especially	ADV
admet-625	22	14	the	the	DET
admet-625	22	15	potency	potency	NOUN
admet-625	22	16	of	of	ADP
admet-625	22	17	its	its	PRON
admet-625	22	18	antioxidant	antioxidant	ADJ
admet-625	22	19	,	,	PUNCT
admet-625	22	20	antiproliferative	antiproliferative	NOUN
admet-625	22	21	,	,	PUNCT
admet-625	22	22	and	and	CCONJ
admet-625	22	23	anti	anti	ADJ
admet-625	22	24	-	-	ADJ
admet-625	22	25	inflammatory	inflammatory	ADJ
admet-625	22	26	action	action	NOUN
admet-625	22	27	via	via	ADP
admet-625	22	28	radical	radical	ADJ
admet-625	22	29	scavenging	scavenging	NOUN
admet-625	22	30	[	[	X
admet-625	22	31	17	17	NUM
admet-625	22	32	]	]	PUNCT
admet-625	22	33	.	.	PUNCT
admet-625	23	1	the	the	DET
admet-625	23	2	application	application	NOUN
admet-625	23	3	in	in	ADP
admet-625	23	4	chemotherapy	chemotherapy	NOUN
admet-625	23	5	in	in	ADP
admet-625	23	6	combination	combination	NOUN
admet-625	23	7	with	with	ADP
admet-625	23	8	other	other	ADJ
admet-625	23	9	substances	substance	NOUN
admet-625	23	10	improves	improve	VERB
admet-625	23	11	both	both	CCONJ
admet-625	23	12	the	the	DET
admet-625	23	13	chances	chance	NOUN
admet-625	23	14	of	of	ADP
admet-625	23	15	survival	survival	NOUN
admet-625	23	16	and	and	CCONJ
admet-625	23	17	quality	quality	NOUN
admet-625	23	18	of	of	ADP
admet-625	23	19	the	the	DET
admet-625	23	20	patients	patient	NOUN
admet-625	23	21	’	’	PART
admet-625	23	22	life	life	NOUN
admet-625	23	23	[	[	X
admet-625	23	24	18	18	NUM
admet-625	23	25	]	]	PUNCT
admet-625	23	26	.	.	PUNCT
admet-625	24	1	in	in	ADP
admet-625	24	2	healthy	healthy	ADJ
admet-625	24	3	people	people	NOUN
admet-625	24	4	,	,	PUNCT
admet-625	24	5	melatonin	melatonin	NOUN
admet-625	24	6	is	be	AUX
admet-625	24	7	endogenously	endogenously	ADV
admet-625	24	8	produced	produce	VERB
admet-625	24	9	by	by	ADP
admet-625	24	10	the	the	DET
admet-625	24	11	pineal	pineal	NOUN
admet-625	24	12	gland	gland	NOUN
admet-625	24	13	.	.	PUNCT
admet-625	25	1	the	the	DET
admet-625	25	2	production	production	NOUN
admet-625	25	3	rhythm	rhythm	NOUN
admet-625	25	4	is	be	AUX
admet-625	25	5	entrained	entrain	VERB
admet-625	25	6	with	with	ADP
admet-625	25	7	the	the	DET
admet-625	25	8	day	day	NOUN
admet-625	25	9	-	-	PUNCT
admet-625	25	10	night	night	NOUN
admet-625	25	11	cycle	cycle	NOUN
admet-625	25	12	,	,	PUNCT
admet-625	25	13	with	with	ADP
admet-625	25	14	darkness	darkness	NOUN
admet-625	25	15	causing	cause	VERB
admet-625	25	16	the	the	DET
admet-625	25	17	onset	onset	NOUN
admet-625	25	18	around	around	ADP
admet-625	25	19	9	9	NUM
admet-625	25	20	-	-	SYM
admet-625	25	21	10	10	NUM
admet-625	25	22	pm	pm	NOUN
admet-625	25	23	,	,	PUNCT
admet-625	25	24	peak	peak	NOUN
admet-625	25	25	between	between	ADP
admet-625	25	26	2	2	NUM
admet-625	25	27	-	-	SYM
admet-625	25	28	4	4	NUM
admet-625	25	29	am	be	AUX
admet-625	25	30	(	(	PUNCT
admet-625	25	31	with	with	ADP
admet-625	25	32	cmax	cmax	NOUN
admet-625	25	33	range	range	VERB
admet-625	25	34	60	60	NUM
admet-625	25	35	-	-	SYM
admet-625	25	36	100	100	NUM
admet-625	25	37	pg	pg	NOUN
admet-625	25	38	/	/	SYM
admet-625	25	39	ml	ml	NOUN
admet-625	25	40	)	)	PUNCT
admet-625	25	41	,	,	PUNCT
admet-625	25	42	and	and	CCONJ
admet-625	25	43	baseline	baseline	VERB
admet-625	25	44	low	low	ADJ
admet-625	25	45	values	value	NOUN
admet-625	25	46	during	during	ADP
admet-625	25	47	the	the	DET
admet-625	25	48	day	day	NOUN
admet-625	25	49	at	at	ADP
admet-625	25	50	about	about	ADV
admet-625	25	51	5	5	NUM
admet-625	25	52	-	-	SYM
admet-625	25	53	10	10	NUM
admet-625	25	54	pg	pg	NOUN
admet-625	25	55	/	/	SYM
admet-625	25	56	ml	ml	PROPN
admet-625	26	1	[	[	X
admet-625	26	2	19	19	NUM
admet-625	26	3	]	]	PUNCT
admet-625	26	4	.	.	PUNCT
admet-625	27	1	however	however	ADV
admet-625	27	2	,	,	PUNCT
admet-625	27	3	this	this	DET
admet-625	27	4	endogenous	endogenous	ADJ
admet-625	27	5	rhythm	rhythm	NOUN
admet-625	27	6	may	may	AUX
admet-625	27	7	be	be	AUX
admet-625	27	8	subject	subject	ADJ
admet-625	27	9	to	to	ADP
admet-625	27	10	either	either	CCONJ
admet-625	27	11	disruption	disruption	NOUN
admet-625	27	12	or	or	CCONJ
admet-625	27	13	levels	level	NOUN
admet-625	27	14	reduction	reduction	NOUN
admet-625	27	15	,	,	PUNCT
admet-625	27	16	and	and	CCONJ
admet-625	27	17	medical	medical	ADJ
admet-625	27	18	doctors	doctor	NOUN
admet-625	27	19	think	think	VERB
admet-625	27	20	that	that	SCONJ
admet-625	27	21	this	this	PRON
admet-625	27	22	has	have	VERB
admet-625	27	23	negative	negative	ADJ
admet-625	27	24	impact	impact	NOUN
admet-625	27	25	on	on	ADP
admet-625	27	26	the	the	DET
admet-625	27	27	patients	patient	NOUN
admet-625	27	28	’	’	PART
admet-625	27	29	health	health	NOUN
admet-625	27	30	status	status	NOUN
admet-625	27	31	,	,	PUNCT
admet-625	27	32	especially	especially	ADV
admet-625	27	33	in	in	ADP
admet-625	27	34	critically	critically	ADJ
admet-625	27	35	ills	ill	NOUN
admet-625	27	36	[	[	X
admet-625	27	37	20	20	NUM
admet-625	27	38	-	-	SYM
admet-625	27	39	22	22	NUM
admet-625	27	40	]	]	PUNCT
admet-625	27	41	.	.	PUNCT
admet-625	28	1	in	in	ADP
admet-625	28	2	order	order	NOUN
admet-625	28	3	to	to	PART
admet-625	28	4	identify	identify	VERB
admet-625	28	5	the	the	DET
admet-625	28	6	optimal	optimal	ADJ
admet-625	28	7	melatonin	melatonin	NOUN
admet-625	28	8	dosage	dosage	NOUN
admet-625	28	9	,	,	PUNCT
admet-625	28	10	a	a	DET
admet-625	28	11	detailed	detailed	ADJ
admet-625	28	12	characterization	characterization	NOUN
admet-625	28	13	of	of	ADP
admet-625	28	14	exogenous	exogenous	ADJ
admet-625	28	15	melatonin	melatonin	NOUN
admet-625	28	16	adme	adme	NOUN
admet-625	28	17	processes	process	NOUN
admet-625	28	18	within	within	ADP
admet-625	28	19	the	the	DET
admet-625	28	20	human	human	ADJ
admet-625	28	21	body	body	NOUN
admet-625	28	22	is	be	AUX
admet-625	28	23	recommended	recommend	VERB
admet-625	28	24	.	.	PUNCT
admet-625	29	1	through	through	ADP
admet-625	29	2	the	the	DET
admet-625	29	3	years	year	NOUN
admet-625	29	4	,	,	PUNCT
admet-625	29	5	several	several	ADJ
admet-625	29	6	authors	author	NOUN
admet-625	29	7	have	have	AUX
admet-625	29	8	carried	carry	VERB
admet-625	29	9	out	out	ADP
admet-625	29	10	pharmacokinetic	pharmacokinetic	ADJ
admet-625	29	11	studies	study	NOUN
admet-625	29	12	to	to	PART
admet-625	29	13	identify	identify	VERB
admet-625	29	14	the	the	DET
admet-625	29	15	most	most	ADV
admet-625	29	16	suitable	suitable	ADJ
admet-625	29	17	dosage	dosage	NOUN
admet-625	29	18	and	and	CCONJ
admet-625	29	19	route	route	NOUN
admet-625	29	20	of	of	ADP
admet-625	29	21	administration	administration	NOUN
admet-625	29	22	to	to	PART
admet-625	29	23	produce	produce	VERB
admet-625	29	24	physiological	physiological	ADJ
admet-625	29	25	and	and	CCONJ
admet-625	29	26	supraphysiological	supraphysiological	ADJ
admet-625	29	27	melatonin	melatonin	NOUN
admet-625	29	28	levels	level	NOUN
admet-625	29	29	in	in	ADP
admet-625	29	30	different	different	ADJ
admet-625	29	31	populations	population	NOUN
admet-625	29	32	[	[	X
admet-625	29	33	23	23	NUM
admet-625	29	34	-	-	SYM
admet-625	29	35	26	26	NUM
admet-625	29	36	]	]	PUNCT
admet-625	29	37	.	.	PUNCT
admet-625	30	1	although	although	SCONJ
admet-625	30	2	some	some	DET
admet-625	30	3	recent	recent	ADJ
admet-625	30	4	works	work	NOUN
admet-625	30	5	exist	exist	VERB
admet-625	30	6	on	on	ADP
admet-625	30	7	the	the	DET
admet-625	30	8	pbpk	pbpk	NOUN
admet-625	30	9	modelling	modelling	NOUN
admet-625	30	10	of	of	ADP
admet-625	30	11	melatonin	melatonin	NOUN
admet-625	30	12	in	in	ADP
admet-625	30	13	the	the	DET
admet-625	30	14	human	human	ADJ
admet-625	30	15	body	body	NOUN
admet-625	30	16	(	(	PUNCT
admet-625	30	17	e.g.	e.g.	ADV
admet-625	30	18	,	,	PUNCT
admet-625	30	19	[	[	X
admet-625	30	20	27	27	NUM
admet-625	30	21	]	]	NUM
admet-625	30	22	)	)	PUNCT
admet-625	30	23	,	,	PUNCT
admet-625	30	24	our	our	PRON
admet-625	30	25	aim	aim	NOUN
admet-625	30	26	is	be	AUX
admet-625	30	27	not	not	PART
admet-625	30	28	only	only	ADV
admet-625	30	29	to	to	PART
admet-625	30	30	provide	provide	VERB
admet-625	30	31	a	a	DET
admet-625	30	32	valuable	valuable	ADJ
admet-625	30	33	pbpk	pbpk	NOUN
admet-625	30	34	model	model	NOUN
admet-625	30	35	but	but	CCONJ
admet-625	30	36	also	also	ADV
admet-625	30	37	to	to	PART
admet-625	30	38	compare	compare	VERB
admet-625	30	39	melatonin	melatonin	NOUN
admet-625	30	40	levels	level	NOUN
admet-625	30	41	that	that	PRON
admet-625	30	42	result	result	VERB
admet-625	30	43	from	from	ADP
admet-625	30	44	different	different	ADJ
admet-625	30	45	routes	route	NOUN
admet-625	30	46	of	of	ADP
admet-625	30	47	administration	administration	NOUN
admet-625	30	48	,	,	PUNCT
admet-625	30	49	i.e.	i.e.	X
admet-625	30	50	intravenous	intravenous	ADJ
admet-625	30	51	(	(	PUNCT
admet-625	30	52	iv	iv	NUM
admet-625	30	53	)	)	PUNCT
admet-625	30	54	,	,	PUNCT
admet-625	30	55	oral	oral	ADJ
admet-625	30	56	(	(	PUNCT
admet-625	30	57	per	per	ADP
admet-625	30	58	os	os	NOUN
admet-625	30	59	,	,	PUNCT
admet-625	30	60	po	po	NOUN
admet-625	30	61	)	)	PUNCT
admet-625	30	62	,	,	PUNCT
admet-625	30	63	and	and	CCONJ
admet-625	30	64	transdermal	transdermal	ADJ
admet-625	30	65	(	(	PUNCT
admet-625	30	66	td	td	NOUN
admet-625	30	67	)	)	PUNCT
admet-625	30	68	.	.	PUNCT
admet-625	31	1	the	the	DET
admet-625	31	2	first	first	ADJ
admet-625	31	3	goal	goal	NOUN
admet-625	31	4	is	be	AUX
admet-625	31	5	to	to	PART
admet-625	31	6	understand	understand	VERB
admet-625	31	7	which	which	DET
admet-625	31	8	route	route	NOUN
admet-625	31	9	has	have	VERB
admet-625	31	10	the	the	DET
admet-625	31	11	highest	high	ADJ
admet-625	31	12	potential	potential	NOUN
admet-625	31	13	to	to	PART
admet-625	31	14	reproduce	reproduce	VERB
admet-625	31	15	the	the	DET
admet-625	31	16	endogenous	endogenous	ADJ
admet-625	31	17	profile	profile	NOUN
admet-625	31	18	of	of	ADP
admet-625	31	19	healthy	healthy	ADJ
admet-625	31	20	patients	patient	NOUN
admet-625	31	21	,	,	PUNCT
admet-625	31	22	with	with	ADP
admet-625	31	23	the	the	DET
admet-625	31	24	purpose	purpose	NOUN
admet-625	31	25	of	of	ADP
admet-625	31	26	restoring	restore	VERB
admet-625	31	27	melatonin	melatonin	NOUN
admet-625	31	28	physiological	physiological	ADJ
admet-625	31	29	roles	role	NOUN
admet-625	31	30	.	.	PUNCT
admet-625	32	1	the	the	DET
admet-625	32	2	second	second	ADJ
admet-625	32	3	goal	goal	NOUN
admet-625	32	4	is	be	AUX
admet-625	32	5	to	to	PART
admet-625	32	6	identify	identify	VERB
admet-625	32	7	the	the	DET
admet-625	32	8	routes	route	NOUN
admet-625	32	9	that	that	PRON
admet-625	32	10	allow	allow	VERB
admet-625	32	11	achieving	achieve	VERB
admet-625	32	12	higher	high	ADJ
admet-625	32	13	levels	level	NOUN
admet-625	32	14	,	,	PUNCT
admet-625	32	15	with	with	ADP
admet-625	32	16	the	the	DET
admet-625	32	17	purpose	purpose	NOUN
admet-625	32	18	of	of	ADP
admet-625	32	19	producing	produce	VERB
admet-625	32	20	pharmacological	pharmacological	ADJ
admet-625	32	21	effects	effect	NOUN
admet-625	32	22	(	(	PUNCT
admet-625	32	23	for	for	ADP
admet-625	32	24	instance	instance	NOUN
admet-625	32	25	strong	strong	ADJ
admet-625	32	26	antioxidative	antioxidative	ADJ
admet-625	32	27	action	action	NOUN
admet-625	32	28	for	for	ADP
admet-625	32	29	icu	icu	PROPN
admet-625	32	30	,	,	PUNCT
admet-625	32	31	intensive	intensive	ADJ
admet-625	32	32	care	care	NOUN
admet-625	32	33	unit	unit	NOUN
admet-625	32	34	,	,	PUNCT
admet-625	32	35	patients	patient	NOUN
admet-625	32	36	)	)	PUNCT
admet-625	32	37	.	.	PUNCT
admet-625	33	1	despite	despite	SCONJ
admet-625	33	2	high	high	ADJ
admet-625	33	3	inter	inter	ADJ
admet-625	33	4	-	-	ADJ
admet-625	33	5	individual	individual	ADJ
admet-625	33	6	variability	variability	NOUN
admet-625	33	7	that	that	PRON
admet-625	33	8	is	be	AUX
admet-625	33	9	typical	typical	ADJ
admet-625	33	10	of	of	ADP
admet-625	33	11	melatonin	melatonin	NOUN
admet-625	33	12	pharmacokinetics	pharmacokinetic	NOUN
admet-625	33	13	(	(	PUNCT
admet-625	33	14	e.g.	e.g.	ADV
admet-625	33	15	,	,	PUNCT
admet-625	33	16	related	relate	VERB
admet-625	33	17	to	to	ADP
admet-625	33	18	different	different	ADJ
admet-625	33	19	physical	physical	ADJ
admet-625	33	20	characteristics	characteristic	NOUN
admet-625	33	21	,	,	PUNCT
admet-625	33	22	genetic	genetic	ADJ
admet-625	33	23	factors	factor	NOUN
admet-625	33	24	,	,	PUNCT
admet-625	33	25	and	and	CCONJ
admet-625	33	26	presence	presence	NOUN
admet-625	33	27	of	of	ADP
admet-625	33	28	impairments	impairment	NOUN
admet-625	33	29	/	/	SYM
admet-625	33	30	diseases	disease	NOUN
admet-625	33	31	)	)	PUNCT
admet-625	33	32	,	,	PUNCT
admet-625	33	33	we	we	PRON
admet-625	33	34	intend	intend	VERB
admet-625	33	35	to	to	PART
admet-625	33	36	show	show	VERB
admet-625	33	37	that	that	SCONJ
admet-625	33	38	in	in	ADP
admet-625	33	39	silico	silico	NOUN
admet-625	33	40	simulations	simulation	NOUN
admet-625	33	41	can	can	AUX
admet-625	33	42	provide	provide	VERB
admet-625	33	43	guidance	guidance	NOUN
admet-625	33	44	and	and	CCONJ
admet-625	33	45	advice	advice	NOUN
admet-625	33	46	in	in	ADP
admet-625	33	47	selecting	select	VERB
admet-625	33	48	the	the	DET
admet-625	33	49	optimal	optimal	ADJ
admet-625	33	50	routes	route	NOUN
admet-625	33	51	of	of	ADP
admet-625	33	52	administration	administration	NOUN
admet-625	33	53	and	and	CCONJ
admet-625	33	54	dosage	dosage	NOUN
admet-625	33	55	,	,	PUNCT
admet-625	33	56	once	once	SCONJ
admet-625	33	57	the	the	DET
admet-625	33	58	reliability	reliability	NOUN
admet-625	33	59	of	of	ADP
admet-625	33	60	the	the	DET
admet-625	33	61	employed	employ	VERB
admet-625	33	62	model	model	NOUN
admet-625	33	63	is	be	AUX
admet-625	33	64	verified	verify	VERB
admet-625	33	65	.	.	PUNCT
admet-625	34	1	indeed	indeed	ADV
admet-625	34	2	,	,	PUNCT
admet-625	34	3	model	model	NOUN
admet-625	34	4	simulations	simulation	NOUN
admet-625	34	5	constitute	constitute	VERB
admet-625	34	6	a	a	DET
admet-625	34	7	powerful	powerful	ADJ
admet-625	34	8	tool	tool	NOUN
admet-625	34	9	for	for	ADP
admet-625	34	10	optimal	optimal	ADJ
admet-625	34	11	pharmacotherapy	pharmacotherapy	NOUN
admet-625	34	12	,	,	PUNCT
admet-625	34	13	especially	especially	ADV
admet-625	34	14	in	in	ADP
admet-625	34	15	combination	combination	NOUN
admet-625	34	16	with	with	ADP
admet-625	34	17	experimental	experimental	ADJ
admet-625	34	18	studies	study	NOUN
admet-625	34	19	.	.	PUNCT
admet-625	35	1	savoca	savoca	PROPN
admet-625	35	2	and	and	CCONJ
admet-625	35	3	manca	manca	PROPN
admet-625	35	4	admet	admet	PROPN
admet-625	35	5	&	&	CCONJ
admet-625	35	6	dmpk	dmpk	PROPN
admet-625	35	7	7(1	7(1	PROPN
admet-625	35	8	)	)	PUNCT
admet-625	35	9	(	(	PUNCT
admet-625	35	10	2019	2019	NUM
admet-625	35	11	)	)	PUNCT
admet-625	35	12	44	44	NUM
admet-625	35	13	-	-	SYM
admet-625	35	14	59	59	NUM
admet-625	35	15	46	46	NUM
admet-625	35	16	methods	method	NOUN
admet-625	35	17	in	in	ADP
admet-625	35	18	general	general	ADJ
admet-625	35	19	,	,	PUNCT
admet-625	35	20	the	the	DET
admet-625	35	21	pbpk	pbpk	ADJ
admet-625	35	22	approach	approach	NOUN
admet-625	35	23	combines	combine	VERB
admet-625	35	24	anatomical	anatomical	ADJ
admet-625	35	25	and	and	CCONJ
admet-625	35	26	physiological	physiological	ADJ
admet-625	35	27	aspects	aspect	NOUN
admet-625	35	28	with	with	ADP
admet-625	35	29	mathematical	mathematical	ADJ
admet-625	35	30	modeling	modeling	NOUN
admet-625	35	31	,	,	PUNCT
admet-625	35	32	by	by	ADP
admet-625	35	33	assuming	assume	VERB
admet-625	35	34	that	that	SCONJ
admet-625	35	35	the	the	DET
admet-625	35	36	organs	organ	NOUN
admet-625	35	37	and	and	CCONJ
admet-625	35	38	tissues	tissue	NOUN
admet-625	35	39	of	of	ADP
admet-625	35	40	the	the	DET
admet-625	35	41	human	human	ADJ
admet-625	35	42	body	body	NOUN
admet-625	35	43	can	can	AUX
admet-625	35	44	be	be	AUX
admet-625	35	45	represented	represent	VERB
admet-625	35	46	by	by	ADP
admet-625	35	47	compartments	compartment	NOUN
admet-625	35	48	with	with	ADP
admet-625	35	49	homogeneous	homogeneous	ADJ
admet-625	35	50	concentration	concentration	NOUN
admet-625	35	51	.	.	PUNCT
admet-625	36	1	the	the	DET
admet-625	36	2	reference	reference	NOUN
admet-625	36	3	model	model	NOUN
admet-625	36	4	of	of	ADP
admet-625	36	5	this	this	DET
admet-625	36	6	work	work	NOUN
admet-625	36	7	(	(	PUNCT
admet-625	36	8	from	from	ADP
admet-625	36	9	[	[	X
admet-625	36	10	28	28	NUM
admet-625	36	11	]	]	PUNCT
admet-625	36	12	)	)	PUNCT
admet-625	36	13	considers	consider	VERB
admet-625	36	14	8	8	NUM
admet-625	36	15	compartments	compartment	NOUN
admet-625	36	16	in	in	ADP
admet-625	36	17	the	the	DET
admet-625	36	18	description	description	NOUN
admet-625	36	19	of	of	ADP
admet-625	36	20	the	the	DET
admet-625	36	21	human	human	ADJ
admet-625	36	22	body	body	NOUN
admet-625	36	23	:	:	PUNCT
admet-625	36	24	plasma	plasma	NOUN
admet-625	36	25	,	,	PUNCT
admet-625	36	26	gastric	gastric	ADJ
admet-625	36	27	lumen	luman	NOUN
admet-625	36	28	(	(	PUNCT
admet-625	36	29	gl	gl	NOUN
admet-625	36	30	)	)	PUNCT
admet-625	36	31	,	,	PUNCT
admet-625	36	32	small	small	ADJ
admet-625	36	33	intestinal	intestinal	ADJ
admet-625	36	34	lumen	luman	NOUN
admet-625	36	35	(	(	PUNCT
admet-625	36	36	sil	sil	PROPN
admet-625	36	37	)	)	PUNCT
admet-625	36	38	,	,	PUNCT
admet-625	36	39	large	large	ADJ
admet-625	36	40	intestinal	intestinal	ADJ
admet-625	36	41	lumen	luman	NOUN
admet-625	36	42	(	(	PUNCT
admet-625	36	43	lil	lil	PROPN
admet-625	36	44	)	)	PUNCT
admet-625	36	45	,	,	PUNCT
admet-625	36	46	liver	liver	NOUN
admet-625	36	47	,	,	PUNCT
admet-625	36	48	gastro	gastro	ADJ
admet-625	36	49	-	-	PUNCT
admet-625	36	50	intestinal	intestinal	ADJ
admet-625	36	51	circulatory	circulatory	ADJ
admet-625	36	52	system	system	NOUN
admet-625	36	53	(	(	PUNCT
admet-625	36	54	gics	gic	NOUN
admet-625	36	55	)	)	PUNCT
admet-625	36	56	,	,	PUNCT
admet-625	36	57	poorly	poorly	ADV
admet-625	36	58	perfused	perfuse	VERB
admet-625	36	59	tissues	tissue	NOUN
admet-625	36	60	(	(	PUNCT
admet-625	36	61	pt	pt	NOUN
admet-625	36	62	)	)	PUNCT
admet-625	36	63	,	,	PUNCT
admet-625	36	64	and	and	CCONJ
admet-625	36	65	highly	highly	ADV
admet-625	36	66	perfused	perfused	ADJ
admet-625	36	67	organs	organ	NOUN
admet-625	36	68	(	(	PUNCT
admet-625	36	69	ho	ho	ADJ
admet-625	36	70	)	)	PUNCT
admet-625	36	71	.	.	PUNCT
admet-625	37	1	actually	actually	ADV
admet-625	37	2	,	,	PUNCT
admet-625	37	3	some	some	DET
admet-625	37	4	compartments	compartment	NOUN
admet-625	37	5	represent	represent	VERB
admet-625	37	6	single	single	ADJ
admet-625	37	7	organs	organ	NOUN
admet-625	37	8	while	while	SCONJ
admet-625	37	9	other	other	ADJ
admet-625	37	10	compartments	compartment	NOUN
admet-625	37	11	represent	represent	VERB
admet-625	37	12	lumped	lump	VERB
admet-625	37	13	parts	part	NOUN
admet-625	37	14	so	so	SCONJ
admet-625	37	15	to	to	PART
admet-625	37	16	reduce	reduce	VERB
admet-625	37	17	the	the	DET
admet-625	37	18	number	number	NOUN
admet-625	37	19	of	of	ADP
admet-625	37	20	model	model	NOUN
admet-625	37	21	parameters	parameter	NOUN
admet-625	37	22	.	.	PUNCT
admet-625	38	1	in	in	ADP
admet-625	38	2	fact	fact	NOUN
admet-625	38	3	,	,	PUNCT
admet-625	38	4	a	a	DET
admet-625	38	5	too	too	ADV
admet-625	38	6	high	high	ADJ
admet-625	38	7	number	number	NOUN
admet-625	38	8	of	of	ADP
admet-625	38	9	parameters	parameter	NOUN
admet-625	38	10	may	may	AUX
admet-625	38	11	lead	lead	VERB
admet-625	38	12	to	to	ADP
admet-625	38	13	mathematical	mathematical	ADJ
admet-625	38	14	predicaments	predicament	NOUN
admet-625	38	15	of	of	ADP
admet-625	38	16	over	over	ADP
admet-625	38	17	-	-	PUNCT
admet-625	38	18	parameterization	parameterization	NOUN
admet-625	38	19	and	and	CCONJ
admet-625	38	20	model	model	NOUN
admet-625	38	21	identification	identification	NOUN
admet-625	38	22	(	(	PUNCT
admet-625	38	23	see	see	VERB
admet-625	38	24	[	[	X
admet-625	38	25	10	10	NUM
admet-625	38	26	]	]	PUNCT
admet-625	38	27	for	for	ADP
admet-625	38	28	an	an	DET
admet-625	38	29	exhaustive	exhaustive	ADJ
admet-625	38	30	discussion	discussion	NOUN
admet-625	38	31	on	on	ADP
admet-625	38	32	this	this	DET
admet-625	38	33	topic	topic	NOUN
admet-625	38	34	)	)	PUNCT
admet-625	38	35	.	.	PUNCT
admet-625	39	1	the	the	DET
admet-625	39	2	ho	ho	PROPN
admet-625	39	3	compartment	compartment	NOUN
admet-625	39	4	stands	stand	VERB
admet-625	39	5	for	for	ADP
admet-625	39	6	organs	organ	NOUN
admet-625	39	7	that	that	PRON
admet-625	39	8	are	be	AUX
admet-625	39	9	highly	highly	ADV
admet-625	39	10	perfused	perfuse	VERB
admet-625	39	11	by	by	ADP
admet-625	39	12	blood	blood	NOUN
admet-625	39	13	,	,	PUNCT
admet-625	39	14	i.e.	i.e.	X
admet-625	39	15	kidneys	kidney	NOUN
admet-625	39	16	,	,	PUNCT
admet-625	39	17	lungs	lung	NOUN
admet-625	39	18	,	,	PUNCT
admet-625	39	19	spleen	spleen	NOUN
admet-625	39	20	,	,	PUNCT
admet-625	39	21	and	and	CCONJ
admet-625	39	22	heart	heart	NOUN
admet-625	39	23	.	.	PUNCT
admet-625	40	1	the	the	DET
admet-625	40	2	pt	pt	PROPN
admet-625	40	3	compartment	compartment	NOUN
admet-625	40	4	lumps	lump	NOUN
admet-625	40	5	tissues	tissue	NOUN
admet-625	40	6	that	that	PRON
admet-625	40	7	are	be	AUX
admet-625	40	8	poorly	poorly	ADV
admet-625	40	9	reached	reach	VERB
admet-625	40	10	by	by	ADP
admet-625	40	11	blood	blood	NOUN
admet-625	40	12	vessels	vessel	NOUN
admet-625	40	13	,	,	PUNCT
admet-625	40	14	e.g.	e.g.	ADV
admet-625	40	15	,	,	PUNCT
admet-625	40	16	adipose	adipose	ADJ
admet-625	40	17	tissue	tissue	NOUN
admet-625	40	18	,	,	PUNCT
admet-625	40	19	skin	skin	NOUN
admet-625	40	20	,	,	PUNCT
admet-625	40	21	and	and	CCONJ
admet-625	40	22	muscles	muscle	NOUN
admet-625	40	23	(	(	PUNCT
admet-625	40	24	specifically	specifically	ADV
admet-625	40	25	in	in	ADP
admet-625	40	26	ill	ill	ADV
admet-625	40	27	/	/	PUNCT
admet-625	40	28	treated	treat	VERB
admet-625	40	29	patients	patient	NOUN
admet-625	40	30	)	)	PUNCT
admet-625	40	31	.	.	PUNCT
admet-625	41	1	the	the	DET
admet-625	41	2	gics	gic	NOUN
admet-625	41	3	compartment	compartment	NOUN
admet-625	41	4	lumps	lump	VERB
admet-625	41	5	the	the	DET
admet-625	41	6	portal	portal	ADJ
admet-625	41	7	vein	vein	VERB
admet-625	41	8	,	,	PUNCT
admet-625	41	9	the	the	DET
admet-625	41	10	mesenteric	mesenteric	ADJ
admet-625	41	11	artery	artery	NOUN
admet-625	41	12	,	,	PUNCT
admet-625	41	13	and	and	CCONJ
admet-625	41	14	the	the	DET
admet-625	41	15	microcirculatory	microcirculatory	ADJ
admet-625	41	16	blood	blood	NOUN
admet-625	41	17	vessels	vessel	NOUN
admet-625	41	18	of	of	ADP
admet-625	41	19	the	the	DET
admet-625	41	20	gastrointestinal	gastrointestinal	ADJ
admet-625	41	21	system	system	NOUN
admet-625	41	22	.	.	PUNCT
admet-625	42	1	we	we	PRON
admet-625	42	2	applied	apply	VERB
admet-625	42	3	some	some	DET
admet-625	42	4	modifications	modification	NOUN
admet-625	42	5	to	to	ADP
admet-625	42	6	this	this	DET
admet-625	42	7	basic	basic	ADJ
admet-625	42	8	structure	structure	NOUN
admet-625	42	9	of	of	ADP
admet-625	42	10	the	the	DET
admet-625	42	11	model	model	NOUN
admet-625	42	12	to	to	PART
admet-625	42	13	adapt	adapt	VERB
admet-625	42	14	it	it	PRON
admet-625	42	15	to	to	ADP
admet-625	42	16	melatonin	melatonin	NOUN
admet-625	42	17	pharmacokinetic	pharmacokinetic	ADJ
admet-625	42	18	features	feature	NOUN
admet-625	42	19	.	.	PUNCT
admet-625	43	1	particularly	particularly	ADV
admet-625	43	2	,	,	PUNCT
admet-625	43	3	we	we	PRON
admet-625	43	4	added	add	VERB
admet-625	43	5	(	(	PUNCT
admet-625	43	6	i	i	NOUN
admet-625	43	7	)	)	PUNCT
admet-625	43	8	the	the	DET
admet-625	43	9	pineal	pineal	NOUN
admet-625	43	10	gland	gland	NOUN
admet-625	43	11	,	,	PUNCT
admet-625	43	12	and	and	CCONJ
admet-625	43	13	(	(	PUNCT
admet-625	43	14	ii	ii	NOUN
admet-625	43	15	)	)	PUNCT
admet-625	43	16	the	the	DET
admet-625	43	17	salivary	salivary	ADJ
admet-625	43	18	glands	gland	NOUN
admet-625	43	19	.	.	PUNCT
admet-625	44	1	pineal	pineal	ADJ
admet-625	44	2	gland	gland	NOUN
admet-625	44	3	is	be	AUX
admet-625	44	4	the	the	DET
admet-625	44	5	source	source	NOUN
admet-625	44	6	of	of	ADP
admet-625	44	7	endogenous	endogenous	ADJ
admet-625	44	8	melatonin	melatonin	NOUN
admet-625	44	9	.	.	PUNCT
admet-625	45	1	within	within	ADP
admet-625	45	2	our	our	PRON
admet-625	45	3	pbpk	pbpk	ADJ
admet-625	45	4	model	model	NOUN
admet-625	45	5	,	,	PUNCT
admet-625	45	6	the	the	DET
admet-625	45	7	material	material	NOUN
admet-625	45	8	balance	balance	NOUN
admet-625	45	9	on	on	ADP
admet-625	45	10	the	the	DET
admet-625	45	11	pineal	pineal	ADJ
admet-625	45	12	gland	gland	NOUN
admet-625	45	13	accounts	account	VERB
admet-625	45	14	for	for	ADP
admet-625	45	15	the	the	DET
admet-625	45	16	production	production	NOUN
admet-625	45	17	of	of	ADP
admet-625	45	18	endogenous	endogenous	ADJ
admet-625	45	19	melatonin	melatonin	NOUN
admet-625	45	20	with	with	ADP
admet-625	45	21	a	a	DET
admet-625	45	22	term	term	NOUN
admet-625	45	23	that	that	PRON
admet-625	45	24	exhibits	exhibit	VERB
admet-625	45	25	a	a	DET
admet-625	45	26	24	24	NUM
admet-625	45	27	-	-	PUNCT
admet-625	45	28	h	h	NOUN
admet-625	45	29	periodicity	periodicity	NOUN
admet-625	45	30	(	(	PUNCT
admet-625	45	31	see	see	VERB
admet-625	45	32	[	[	X
admet-625	45	33	2	2	NUM
admet-625	45	34	]	]	NUM
admet-625	45	35	)	)	PUNCT
admet-625	45	36	.	.	PUNCT
admet-625	46	1	several	several	ADJ
admet-625	46	2	authors	author	NOUN
admet-625	46	3	evaluate	evaluate	VERB
admet-625	46	4	melatonin	melatonin	NOUN
admet-625	46	5	endogenous	endogenous	ADJ
admet-625	46	6	and	and	CCONJ
admet-625	46	7	exogenous	exogenous	ADJ
admet-625	46	8	amount	amount	NOUN
admet-625	46	9	by	by	ADP
admet-625	46	10	measuring	measure	VERB
admet-625	46	11	either	either	CCONJ
admet-625	46	12	saliva	saliva	NOUN
admet-625	46	13	and	and	CCONJ
admet-625	46	14	plasma	plasma	NOUN
admet-625	46	15	or	or	CCONJ
admet-625	46	16	only	only	ADV
admet-625	46	17	saliva	saliva	NOUN
admet-625	46	18	concentrations	concentration	NOUN
admet-625	46	19	[	[	X
admet-625	46	20	29	29	NUM
admet-625	46	21	-	-	SYM
admet-625	46	22	32	32	NUM
admet-625	46	23	]	]	PUNCT
admet-625	46	24	.	.	PUNCT
admet-625	47	1	thus	thus	ADV
admet-625	47	2	,	,	PUNCT
admet-625	47	3	we	we	PRON
admet-625	47	4	found	find	VERB
admet-625	47	5	more	more	ADV
admet-625	47	6	correct	correct	ADJ
admet-625	47	7	(	(	PUNCT
admet-625	47	8	from	from	ADP
admet-625	47	9	a	a	DET
admet-625	47	10	physiological	physiological	ADJ
admet-625	47	11	point	point	NOUN
admet-625	47	12	of	of	ADP
admet-625	47	13	view	view	NOUN
admet-625	47	14	)	)	PUNCT
admet-625	47	15	to	to	PART
admet-625	47	16	add	add	VERB
admet-625	47	17	the	the	DET
admet-625	47	18	salivary	salivary	ADJ
admet-625	47	19	glands	gland	NOUN
admet-625	47	20	to	to	ADP
admet-625	47	21	the	the	DET
admet-625	47	22	model	model	NOUN
admet-625	47	23	compartments	compartment	NOUN
admet-625	47	24	.	.	PUNCT
admet-625	48	1	the	the	DET
admet-625	48	2	drug	drug	NOUN
admet-625	48	3	material	material	NOUN
admet-625	48	4	balances	balance	NOUN
admet-625	48	5	,	,	PUNCT
admet-625	48	6	in	in	ADP
admet-625	48	7	the	the	DET
admet-625	48	8	form	form	NOUN
admet-625	48	9	of	of	ADP
admet-625	48	10	an	an	DET
admet-625	48	11	ode	ode	ADJ
admet-625	48	12	system	system	NOUN
admet-625	48	13	,	,	PUNCT
admet-625	48	14	describe	describe	VERB
admet-625	48	15	the	the	DET
admet-625	48	16	concentration	concentration	NOUN
admet-625	48	17	dynamics	dynamic	NOUN
admet-625	48	18	of	of	ADP
admet-625	48	19	melatonin	melatonin	NOUN
admet-625	48	20	in	in	ADP
admet-625	48	21	each	each	DET
admet-625	48	22	compartment	compartment	NOUN
admet-625	48	23	.	.	PUNCT
admet-625	49	1	finally	finally	ADV
admet-625	49	2	,	,	PUNCT
admet-625	49	3	an	an	DET
admet-625	49	4	additional	additional	ADJ
admet-625	49	5	equation	equation	NOUN
admet-625	49	6	allows	allow	VERB
admet-625	49	7	accounting	account	VERB
admet-625	49	8	for	for	ADP
admet-625	49	9	the	the	DET
admet-625	49	10	dynamics	dynamic	NOUN
admet-625	49	11	of	of	ADP
admet-625	49	12	melatonin	melatonin	NOUN
admet-625	49	13	main	main	ADJ
admet-625	49	14	metabolite	metabolite	NOUN
admet-625	49	15	6	6	NUM
admet-625	49	16	-	-	PUNCT
admet-625	49	17	sulfatoxymelatonin	sulfatoxymelatonin	NOUN
admet-625	49	18	(	(	PUNCT
admet-625	49	19	amt6s	amt6s	ADJ
admet-625	49	20	)	)	PUNCT
admet-625	49	21	.	.	PUNCT
admet-625	50	1	in	in	ADP
admet-625	50	2	case	case	NOUN
admet-625	50	3	of	of	ADP
admet-625	50	4	iv	iv	NUM
admet-625	50	5	route	route	NOUN
admet-625	50	6	,	,	PUNCT
admet-625	50	7	the	the	DET
admet-625	50	8	drug	drug	NOUN
admet-625	50	9	directly	directly	ADV
admet-625	50	10	inputs	input	VERB
admet-625	50	11	the	the	DET
admet-625	50	12	plasma	plasma	NOUN
admet-625	50	13	compartment	compartment	NOUN
admet-625	50	14	.	.	PUNCT
admet-625	51	1	conversely	conversely	ADV
admet-625	51	2	,	,	PUNCT
admet-625	51	3	in	in	ADP
admet-625	51	4	case	case	NOUN
admet-625	51	5	of	of	ADP
admet-625	51	6	po	po	PROPN
admet-625	51	7	administration	administration	PROPN
admet-625	51	8	,	,	PUNCT
admet-625	51	9	the	the	DET
admet-625	51	10	drug	drug	NOUN
admet-625	51	11	enters	enter	VERB
admet-625	51	12	the	the	DET
admet-625	51	13	gl	gl	NOUN
admet-625	51	14	and	and	CCONJ
admet-625	51	15	moves	move	VERB
admet-625	51	16	through	through	ADP
admet-625	51	17	sil	sil	PROPN
admet-625	51	18	and	and	CCONJ
admet-625	51	19	lil	lil	VERB
admet-625	51	20	to	to	PART
admet-625	51	21	be	be	AUX
admet-625	51	22	absorbed	absorb	VERB
admet-625	51	23	through	through	ADP
admet-625	51	24	the	the	DET
admet-625	51	25	intestinal	intestinal	ADJ
admet-625	51	26	walls	wall	NOUN
admet-625	51	27	and	and	CCONJ
admet-625	51	28	conveyed	convey	VERB
admet-625	51	29	to	to	PART
admet-625	51	30	liver	liver	VERB
admet-625	51	31	via	via	ADP
admet-625	51	32	the	the	DET
admet-625	51	33	portal	portal	ADJ
admet-625	51	34	vein	vein	NOUN
admet-625	51	35	.	.	PUNCT
admet-625	52	1	this	this	PRON
admet-625	52	2	results	result	VERB
admet-625	52	3	into	into	ADP
admet-625	52	4	the	the	DET
admet-625	52	5	so	so	ADV
admet-625	52	6	called	call	VERB
admet-625	52	7	“	"	PUNCT
admet-625	52	8	first	first	ADJ
admet-625	52	9	-	-	PUNCT
admet-625	52	10	pass	pass	VERB
admet-625	52	11	metabolism	metabolism	NOUN
admet-625	52	12	effect	effect	NOUN
admet-625	52	13	”	"	PUNCT
admet-625	52	14	.	.	PUNCT
admet-625	53	1	after	after	ADP
admet-625	53	2	that	that	PRON
admet-625	53	3	,	,	PUNCT
admet-625	53	4	it	it	PRON
admet-625	53	5	is	be	AUX
admet-625	53	6	drained	drain	VERB
admet-625	53	7	from	from	ADP
admet-625	53	8	the	the	DET
admet-625	53	9	liver	liver	NOUN
admet-625	53	10	to	to	PART
admet-625	53	11	reach	reach	VERB
admet-625	53	12	the	the	DET
admet-625	53	13	systemic	systemic	ADJ
admet-625	53	14	circulation	circulation	NOUN
admet-625	53	15	and	and	CCONJ
admet-625	53	16	distributes	distribute	VERB
admet-625	53	17	to	to	ADP
admet-625	53	18	the	the	DET
admet-625	53	19	other	other	ADJ
admet-625	53	20	organs	organ	NOUN
admet-625	53	21	and	and	CCONJ
admet-625	53	22	tissues	tissue	NOUN
admet-625	53	23	via	via	ADP
admet-625	53	24	the	the	DET
admet-625	53	25	bloodstream	bloodstream	NOUN
admet-625	53	26	.	.	PUNCT
admet-625	54	1	it	it	PRON
admet-625	54	2	is	be	AUX
admet-625	54	3	worth	worth	ADJ
admet-625	54	4	stressing	stress	VERB
admet-625	54	5	that	that	SCONJ
admet-625	54	6	the	the	DET
admet-625	54	7	model	model	NOUN
admet-625	54	8	structure	structure	NOUN
admet-625	54	9	takes	take	VERB
admet-625	54	10	into	into	ADP
admet-625	54	11	consideration	consideration	NOUN
admet-625	54	12	gl	gl	PROPN
admet-625	54	13	,	,	PUNCT
admet-625	54	14	sil	sil	PROPN
admet-625	54	15	,	,	PUNCT
admet-625	54	16	and	and	CCONJ
admet-625	54	17	lil	lil	VERB
admet-625	54	18	only	only	ADV
admet-625	54	19	in	in	ADP
admet-625	54	20	case	case	NOUN
admet-625	54	21	of	of	ADP
admet-625	54	22	po	po	PROPN
admet-625	54	23	administration	administration	NOUN
admet-625	54	24	.	.	PUNCT
admet-625	55	1	in	in	ADP
admet-625	55	2	fact	fact	NOUN
admet-625	55	3	,	,	PUNCT
admet-625	55	4	in	in	ADP
admet-625	55	5	other	other	ADJ
admet-625	55	6	cases	case	NOUN
admet-625	55	7	,	,	PUNCT
admet-625	55	8	we	we	PRON
admet-625	55	9	assume	assume	VERB
admet-625	55	10	that	that	SCONJ
admet-625	55	11	the	the	DET
admet-625	55	12	drug	drug	NOUN
admet-625	55	13	counterdiffusion	counterdiffusion	NOUN
admet-625	55	14	from	from	ADP
admet-625	55	15	gics	gic	NOUN
admet-625	55	16	to	to	PART
admet-625	55	17	sil	sil	VERB
admet-625	55	18	and	and	CCONJ
admet-625	55	19	lil	lil	NOUN
admet-625	55	20	is	be	AUX
admet-625	55	21	negligible	negligible	ADJ
admet-625	55	22	,	,	PUNCT
admet-625	55	23	and	and	CCONJ
admet-625	55	24	therefore	therefore	ADV
admet-625	55	25	it	it	PRON
admet-625	55	26	is	be	AUX
admet-625	55	27	possible	possible	ADJ
admet-625	55	28	to	to	PART
admet-625	55	29	neglect	neglect	VERB
admet-625	55	30	such	such	ADJ
admet-625	55	31	compartments	compartment	NOUN
admet-625	55	32	,	,	PUNCT
admet-625	55	33	along	along	ADP
admet-625	55	34	with	with	ADP
admet-625	55	35	gl	gl	NOUN
admet-625	55	36	and	and	CCONJ
admet-625	55	37	reduce	reduce	VERB
admet-625	55	38	significantly	significantly	ADV
admet-625	55	39	the	the	DET
admet-625	55	40	number	number	NOUN
admet-625	55	41	of	of	ADP
admet-625	55	42	odes	ode	NOUN
admet-625	55	43	.	.	PUNCT
admet-625	56	1	we	we	PRON
admet-625	56	2	do	do	AUX
admet-625	56	3	not	not	PART
admet-625	56	4	report	report	VERB
admet-625	56	5	here	here	ADV
admet-625	56	6	the	the	DET
admet-625	56	7	complete	complete	ADJ
admet-625	56	8	mathematical	mathematical	ADJ
admet-625	56	9	description	description	NOUN
admet-625	56	10	of	of	ADP
admet-625	56	11	the	the	DET
admet-625	56	12	model	model	NOUN
admet-625	56	13	,	,	PUNCT
admet-625	56	14	as	as	SCONJ
admet-625	56	15	it	it	PRON
admet-625	56	16	is	be	AUX
admet-625	56	17	extensively	extensively	ADV
admet-625	56	18	detailed	detailed	ADJ
admet-625	56	19	in	in	ADP
admet-625	56	20	[	[	X
admet-625	56	21	10,28	10,28	NOUN
admet-625	56	22	]	]	X
admet-625	56	23	.	.	PUNCT
admet-625	57	1	while	while	SCONJ
admet-625	57	2	in	in	ADP
admet-625	57	3	case	case	NOUN
admet-625	57	4	of	of	ADP
admet-625	57	5	iv	iv	NUM
admet-625	57	6	and	and	CCONJ
admet-625	57	7	po	po	NOUN
admet-625	57	8	routes	route	NOUN
admet-625	57	9	,	,	PUNCT
admet-625	57	10	the	the	DET
admet-625	57	11	skin	skin	NOUN
admet-625	57	12	is	be	AUX
admet-625	57	13	incorporated	incorporate	VERB
admet-625	57	14	into	into	ADP
admet-625	57	15	the	the	DET
admet-625	57	16	pt	pt	NOUN
admet-625	57	17	compartment	compartment	NOUN
admet-625	57	18	,	,	PUNCT
admet-625	57	19	in	in	ADP
admet-625	57	20	case	case	NOUN
admet-625	57	21	of	of	ADP
admet-625	57	22	td	td	PROPN
admet-625	57	23	administration	administration	NOUN
admet-625	57	24	the	the	DET
admet-625	57	25	skin	skin	NOUN
admet-625	57	26	becomes	become	VERB
admet-625	57	27	the	the	DET
admet-625	57	28	mean	mean	NOUN
admet-625	57	29	for	for	ADP
admet-625	57	30	drug	drug	NOUN
admet-625	57	31	absorption	absorption	NOUN
admet-625	57	32	and	and	CCONJ
admet-625	57	33	therefore	therefore	ADV
admet-625	57	34	calls	call	VERB
admet-625	57	35	for	for	ADP
admet-625	57	36	a	a	DET
admet-625	57	37	specific	specific	ADJ
admet-625	57	38	and	and	CCONJ
admet-625	57	39	detailed	detailed	ADJ
admet-625	57	40	description	description	NOUN
admet-625	57	41	.	.	PUNCT
admet-625	58	1	in	in	ADP
admet-625	58	2	particular	particular	ADJ
admet-625	58	3	,	,	PUNCT
admet-625	58	4	melatonin	melatonin	NOUN
admet-625	58	5	evolution	evolution	NOUN
admet-625	58	6	has	have	VERB
admet-625	58	7	to	to	PART
admet-625	58	8	be	be	AUX
admet-625	58	9	considered	consider	VERB
admet-625	58	10	not	not	PART
admet-625	58	11	only	only	ADV
admet-625	58	12	in	in	ADP
admet-625	58	13	time	time	NOUN
admet-625	58	14	but	but	CCONJ
admet-625	58	15	also	also	ADV
admet-625	58	16	along	along	ADP
admet-625	58	17	the	the	DET
admet-625	58	18	skin	skin	NOUN
admet-625	58	19	depth	depth	NOUN
admet-625	58	20	coordinate	coordinate	NOUN
admet-625	58	21	.	.	PUNCT
admet-625	59	1	thus	thus	ADV
admet-625	59	2	,	,	PUNCT
admet-625	59	3	the	the	DET
admet-625	59	4	homogenous	homogenous	ADJ
admet-625	59	5	approach	approach	NOUN
admet-625	59	6	(	(	PUNCT
admet-625	59	7	based	base	VERB
admet-625	59	8	on	on	ADP
admet-625	59	9	the	the	DET
admet-625	59	10	perfectly	perfectly	ADV
admet-625	59	11	mixed	mixed	ADJ
admet-625	59	12	hypothesis	hypothesis	NOUN
admet-625	59	13	)	)	PUNCT
admet-625	59	14	to	to	PART
admet-625	59	15	compartment	compartment	VERB
admet-625	59	16	modeling	modeling	NOUN
admet-625	59	17	is	be	AUX
admet-625	59	18	replaced	replace	VERB
admet-625	59	19	and	and	CCONJ
admet-625	59	20	the	the	DET
admet-625	59	21	resulting	result	VERB
admet-625	59	22	skin	skin	NOUN
admet-625	59	23	mathematical	mathematical	ADJ
admet-625	59	24	description	description	NOUN
admet-625	59	25	involves	involve	VERB
admet-625	59	26	partial	partial	ADJ
admet-625	59	27	differential	differential	ADJ
admet-625	59	28	equations	equation	NOUN
admet-625	59	29	(	(	PUNCT
admet-625	59	30	pdes	pde	NOUN
admet-625	59	31	)	)	PUNCT
admet-625	59	32	with	with	ADP
admet-625	59	33	suitable	suitable	ADJ
admet-625	59	34	boundary	boundary	ADJ
admet-625	59	35	conditions	condition	NOUN
admet-625	59	36	[	[	X
admet-625	59	37	2	2	NUM
admet-625	59	38	]	]	PUNCT
admet-625	59	39	.	.	PUNCT
admet-625	60	1	particularly	particularly	ADV
admet-625	60	2	,	,	PUNCT
admet-625	60	3	three	three	NUM
admet-625	60	4	skin	skin	NOUN
admet-625	60	5	layers	layer	NOUN
admet-625	60	6	are	be	AUX
admet-625	60	7	considered	consider	VERB
admet-625	60	8	:	:	PUNCT
admet-625	60	9	(	(	PUNCT
admet-625	60	10	i	i	NOUN
admet-625	60	11	)	)	PUNCT
admet-625	60	12	stratum	stratum	PROPN
admet-625	60	13	corneum	corneum	NOUN
admet-625	60	14	that	that	PRON
admet-625	60	15	is	be	AUX
admet-625	60	16	the	the	DET
admet-625	60	17	most	most	ADV
admet-625	60	18	external	external	ADJ
admet-625	60	19	and	and	CCONJ
admet-625	60	20	thinnest	thin	ADJ
admet-625	60	21	but	but	CCONJ
admet-625	60	22	also	also	ADV
admet-625	60	23	the	the	DET
admet-625	60	24	main	main	ADJ
admet-625	60	25	barrier	barrier	NOUN
admet-625	60	26	,	,	PUNCT
admet-625	60	27	(	(	PUNCT
admet-625	60	28	ii	ii	NOUN
admet-625	60	29	)	)	PUNCT
admet-625	60	30	viable	viable	ADJ
admet-625	60	31	epidermis	epidermis	NOUN
admet-625	60	32	that	that	PRON
admet-625	60	33	may	may	AUX
admet-625	60	34	constitute	constitute	VERB
admet-625	60	35	a	a	DET
admet-625	60	36	metabolism	metabolism	NOUN
admet-625	60	37	site	site	NOUN
admet-625	60	38	,	,	PUNCT
admet-625	60	39	and	and	CCONJ
admet-625	60	40	(	(	PUNCT
admet-625	60	41	iii	iii	NOUN
admet-625	60	42	)	)	PUNCT
admet-625	60	43	dermis	dermis	NOUN
admet-625	60	44	,	,	PUNCT
admet-625	60	45	from	from	ADP
admet-625	60	46	which	which	PRON
admet-625	60	47	the	the	DET
admet-625	60	48	drug	drug	NOUN
admet-625	60	49	is	be	AUX
admet-625	60	50	supposed	suppose	VERB
admet-625	60	51	to	to	PART
admet-625	60	52	reach	reach	VERB
admet-625	60	53	the	the	DET
admet-625	60	54	systemic	systemic	ADJ
admet-625	60	55	circulation	circulation	NOUN
admet-625	60	56	via	via	ADP
admet-625	60	57	the	the	DET
admet-625	60	58	contained	contain	VERB
admet-625	60	59	blood	blood	NOUN
admet-625	60	60	vessels	vessel	NOUN
admet-625	60	61	,	,	PUNCT
admet-625	60	62	and	and	CCONJ
admet-625	60	63	then	then	ADV
admet-625	60	64	distribute	distribute	VERB
admet-625	60	65	to	to	ADP
admet-625	60	66	the	the	DET
admet-625	60	67	rest	rest	NOUN
admet-625	60	68	of	of	ADP
admet-625	60	69	the	the	DET
admet-625	60	70	body	body	NOUN
admet-625	60	71	.	.	PUNCT
admet-625	61	1	in	in	ADP
admet-625	61	2	case	case	NOUN
admet-625	61	3	of	of	ADP
admet-625	61	4	td	td	PROPN
admet-625	61	5	administration	administration	NOUN
admet-625	61	6	,	,	PUNCT
admet-625	61	7	the	the	DET
admet-625	61	8	pdes	pde	NOUN
admet-625	61	9	describing	describe	VERB
admet-625	61	10	the	the	DET
admet-625	61	11	skin	skin	NOUN
admet-625	61	12	and	and	CCONJ
admet-625	61	13	the	the	DET
admet-625	61	14	odes	ode	NOUN
admet-625	61	15	describing	describe	VERB
admet-625	61	16	the	the	DET
admet-625	61	17	rest	rest	NOUN
admet-625	61	18	of	of	ADP
admet-625	61	19	the	the	DET
admet-625	61	20	body	body	NOUN
admet-625	61	21	admet	admet	NOUN
admet-625	61	22	&	&	CCONJ
admet-625	61	23	dmpk	dmpk	PROPN
admet-625	61	24	7(1	7(1	PROPN
admet-625	61	25	)	)	PUNCT
admet-625	61	26	(	(	PUNCT
admet-625	61	27	2019	2019	NUM
admet-625	61	28	)	)	PUNCT
admet-625	61	29	44	44	NUM
admet-625	61	30	-	-	SYM
admet-625	61	31	59	59	NUM
admet-625	61	32	pbpk	pbpk	ADJ
admet-625	61	33	simulation	simulation	NOUN
admet-625	61	34	in	in	ADP
admet-625	61	35	pharmacotherapy	pharmacotherapy	NOUN
admet-625	61	36	doi	doi	NOUN
admet-625	61	37	:	:	PUNCT
admet-625	61	38	10.5599	10.5599	NUM
admet-625	61	39	/	/	SYM
admet-625	61	40	admet.625	admet.625	NUM
admet-625	61	41	47	47	NUM
admet-625	61	42	are	be	AUX
admet-625	61	43	combined	combine	VERB
admet-625	61	44	via	via	ADP
admet-625	61	45	the	the	DET
admet-625	61	46	finite	finite	PROPN
admet-625	61	47	differences	difference	NOUN
admet-625	61	48	method	method	NOUN
admet-625	61	49	.	.	PUNCT
admet-625	62	1	in	in	ADP
admet-625	62	2	fact	fact	NOUN
admet-625	62	3	,	,	PUNCT
admet-625	62	4	the	the	DET
admet-625	62	5	pdes	pde	NOUN
admet-625	62	6	are	be	AUX
admet-625	62	7	discretized	discretize	VERB
admet-625	62	8	respect	respect	NOUN
admet-625	62	9	to	to	ADP
admet-625	62	10	the	the	DET
admet-625	62	11	spatial	spatial	ADJ
admet-625	62	12	coordinate	coordinate	NOUN
admet-625	62	13	(	(	PUNCT
admet-625	62	14	i.e.	i.e.	X
admet-625	62	15	skin	skin	NOUN
admet-625	62	16	depth	depth	NOUN
admet-625	62	17	)	)	PUNCT
admet-625	62	18	and	and	CCONJ
admet-625	62	19	therefore	therefore	ADV
admet-625	62	20	converted	convert	VERB
admet-625	62	21	to	to	ADP
admet-625	62	22	odes	ode	NOUN
admet-625	62	23	[	[	X
admet-625	62	24	2	2	NUM
admet-625	62	25	]	]	PUNCT
admet-625	62	26	.	.	PUNCT
admet-625	63	1	independently	independently	ADV
admet-625	63	2	of	of	ADP
admet-625	63	3	the	the	DET
admet-625	63	4	administration	administration	NOUN
admet-625	63	5	pathway	pathway	NOUN
admet-625	63	6	,	,	PUNCT
admet-625	63	7	the	the	DET
admet-625	63	8	model	model	NOUN
admet-625	63	9	parameters	parameter	NOUN
admet-625	63	10	can	can	AUX
admet-625	63	11	be	be	AUX
admet-625	63	12	divided	divide	VERB
admet-625	63	13	into	into	ADP
admet-625	63	14	three	three	NUM
admet-625	63	15	categories	category	NOUN
admet-625	63	16	:	:	PUNCT
admet-625	63	17	(	(	PUNCT
admet-625	63	18	i	i	NOUN
admet-625	63	19	)	)	PUNCT
admet-625	63	20	individualized	individualize	VERB
admet-625	63	21	,	,	PUNCT
admet-625	63	22	(	(	PUNCT
admet-625	63	23	ii	ii	NOUN
admet-625	63	24	)	)	PUNCT
admet-625	63	25	assigned	assign	VERB
admet-625	63	26	,	,	PUNCT
admet-625	63	27	and	and	CCONJ
admet-625	63	28	(	(	PUNCT
admet-625	63	29	iii	iii	NOUN
admet-625	63	30	)	)	PUNCT
admet-625	63	31	regressed	regress	VERB
admet-625	63	32	.	.	PUNCT
admet-625	64	1	individualized	individualized	ADJ
admet-625	64	2	parameters	parameter	NOUN
admet-625	64	3	(	(	PUNCT
admet-625	64	4	e.g.	e.g.	ADV
admet-625	64	5	,	,	PUNCT
admet-625	64	6	volumes	volume	NOUN
admet-625	64	7	of	of	ADP
admet-625	64	8	compartments	compartment	NOUN
admet-625	64	9	and	and	CCONJ
admet-625	64	10	flowrates	flowrate	VERB
admet-625	64	11	among	among	ADP
admet-625	64	12	them	they	PRON
admet-625	64	13	)	)	PUNCT
admet-625	64	14	are	be	AUX
admet-625	64	15	calculated	calculate	VERB
admet-625	64	16	according	accord	VERB
admet-625	64	17	to	to	ADP
admet-625	64	18	empirical	empirical	ADJ
admet-625	64	19	correlations	correlation	NOUN
admet-625	64	20	that	that	PRON
admet-625	64	21	are	be	AUX
admet-625	64	22	available	available	ADJ
admet-625	64	23	in	in	ADP
admet-625	64	24	the	the	DET
admet-625	64	25	literature	literature	NOUN
admet-625	64	26	and	and	CCONJ
admet-625	64	27	depend	depend	VERB
admet-625	64	28	on	on	ADP
admet-625	64	29	the	the	DET
admet-625	64	30	patients	patient	NOUN
admet-625	64	31	’	'	PUNCT
admet-625	64	32	physical	physical	ADJ
admet-625	64	33	characteristics	characteristic	NOUN
admet-625	64	34	.	.	PUNCT
admet-625	65	1	we	we	PRON
admet-625	65	2	consider	consider	VERB
admet-625	65	3	as	as	SCONJ
admet-625	65	4	specific	specific	ADJ
admet-625	65	5	features	feature	VERB
admet-625	65	6	the	the	DET
admet-625	65	7	sex	sex	NOUN
admet-625	65	8	,	,	PUNCT
admet-625	65	9	body	body	NOUN
admet-625	65	10	weight	weight	NOUN
admet-625	65	11	,	,	PUNCT
admet-625	65	12	and	and	CCONJ
admet-625	65	13	height	height	NOUN
admet-625	65	14	.	.	PUNCT
admet-625	66	1	assigned	assign	VERB
admet-625	66	2	parameters	parameter	NOUN
admet-625	66	3	are	be	AUX
admet-625	66	4	some	some	DET
admet-625	66	5	drug	drug	NOUN
admet-625	66	6	physicochemical	physicochemical	ADJ
admet-625	66	7	properties	property	NOUN
admet-625	66	8	whose	whose	DET
admet-625	66	9	value	value	NOUN
admet-625	66	10	can	can	AUX
admet-625	66	11	be	be	AUX
admet-625	66	12	determined	determine	VERB
admet-625	66	13	from	from	ADP
admet-625	66	14	the	the	DET
admet-625	66	15	scientific	scientific	ADJ
admet-625	66	16	literature	literature	NOUN
admet-625	66	17	(	(	PUNCT
admet-625	66	18	e.g.	e.g.	ADV
admet-625	66	19	,	,	PUNCT
admet-625	66	20	protein	protein	NOUN
admet-625	66	21	binding	bind	VERB
admet-625	66	22	)	)	PUNCT
admet-625	66	23	.	.	PUNCT
admet-625	67	1	some	some	DET
admet-625	67	2	parameters	parameter	NOUN
admet-625	67	3	,	,	PUNCT
admet-625	67	4	strictly	strictly	ADV
admet-625	67	5	related	relate	VERB
admet-625	67	6	to	to	ADP
admet-625	67	7	the	the	DET
admet-625	67	8	transport	transport	NOUN
admet-625	67	9	properties	property	NOUN
admet-625	67	10	,	,	PUNCT
admet-625	67	11	can	can	AUX
admet-625	67	12	be	be	AUX
admet-625	67	13	neither	neither	PRON
admet-625	67	14	found	find	VERB
admet-625	67	15	in	in	ADP
admet-625	67	16	the	the	DET
admet-625	67	17	literature	literature	NOUN
admet-625	67	18	nor	nor	CCONJ
admet-625	67	19	calculated	calculate	VERB
admet-625	67	20	by	by	ADP
admet-625	67	21	empirical	empirical	ADJ
admet-625	67	22	correlations	correlation	NOUN
admet-625	67	23	(	(	PUNCT
admet-625	67	24	e.g.	e.g.	ADV
admet-625	67	25	,	,	PUNCT
admet-625	67	26	diffusivity	diffusivity	NOUN
admet-625	67	27	,	,	PUNCT
admet-625	67	28	transfer	transfer	NOUN
admet-625	67	29	coefficients	coefficient	NOUN
admet-625	67	30	,	,	PUNCT
admet-625	67	31	metabolic	metabolic	NOUN
admet-625	67	32	constants	constant	NOUN
admet-625	67	33	)	)	PUNCT
admet-625	67	34	,	,	PUNCT
admet-625	67	35	thus	thus	ADV
admet-625	67	36	they	they	PRON
admet-625	67	37	are	be	AUX
admet-625	67	38	obtained	obtain	VERB
admet-625	67	39	via	via	ADP
admet-625	67	40	a	a	DET
admet-625	67	41	nonlinear	nonlinear	ADJ
admet-625	67	42	regression	regression	NOUN
admet-625	67	43	procedure	procedure	NOUN
admet-625	67	44	respect	respect	NOUN
admet-625	67	45	to	to	ADP
admet-625	67	46	experimental	experimental	ADJ
admet-625	67	47	data	datum	NOUN
admet-625	67	48	from	from	ADP
admet-625	67	49	the	the	DET
admet-625	67	50	literature	literature	NOUN
admet-625	67	51	.	.	PUNCT
admet-625	68	1	indeed	indeed	ADV
admet-625	68	2	,	,	PUNCT
admet-625	68	3	although	although	SCONJ
admet-625	68	4	the	the	DET
admet-625	68	5	value	value	NOUN
admet-625	68	6	of	of	ADP
admet-625	68	7	some	some	DET
admet-625	68	8	transfer	transfer	NOUN
admet-625	68	9	coefficients	coefficient	NOUN
admet-625	68	10	might	might	AUX
admet-625	68	11	be	be	AUX
admet-625	68	12	determined	determine	VERB
admet-625	68	13	from	from	ADP
admet-625	68	14	in	in	ADP
admet-625	68	15	vitro	vitro	X
admet-625	68	16	studies	study	NOUN
admet-625	68	17	,	,	PUNCT
admet-625	68	18	such	such	ADJ
admet-625	68	19	experiments	experiment	NOUN
admet-625	68	20	would	would	AUX
admet-625	68	21	not	not	PART
admet-625	68	22	account	account	VERB
admet-625	68	23	for	for	ADP
admet-625	68	24	the	the	DET
admet-625	68	25	interactions	interaction	NOUN
admet-625	68	26	among	among	ADP
admet-625	68	27	organs	organ	NOUN
admet-625	68	28	and	and	CCONJ
admet-625	68	29	tissues	tissue	NOUN
admet-625	68	30	in	in	ADP
admet-625	68	31	the	the	DET
admet-625	68	32	living	living	NOUN
admet-625	68	33	organism	organism	NOUN
admet-625	68	34	,	,	PUNCT
admet-625	68	35	and	and	CCONJ
admet-625	68	36	therefore	therefore	ADV
admet-625	68	37	would	would	AUX
admet-625	68	38	affect	affect	VERB
admet-625	68	39	the	the	DET
admet-625	68	40	reliability	reliability	NOUN
admet-625	68	41	of	of	ADP
admet-625	68	42	the	the	DET
admet-625	68	43	mathematical	mathematical	ADJ
admet-625	68	44	model	model	NOUN
admet-625	68	45	and	and	CCONJ
admet-625	68	46	consistency	consistency	NOUN
admet-625	68	47	/	/	SYM
admet-625	68	48	validity	validity	NOUN
admet-625	68	49	of	of	ADP
admet-625	68	50	the	the	DET
admet-625	68	51	simulated	simulate	VERB
admet-625	68	52	results	result	NOUN
admet-625	68	53	.	.	PUNCT
admet-625	69	1	once	once	SCONJ
admet-625	69	2	the	the	DET
admet-625	69	3	model	model	NOUN
admet-625	69	4	transfer	transfer	NOUN
admet-625	69	5	coefficients	coefficient	NOUN
admet-625	69	6	and	and	CCONJ
admet-625	69	7	metabolic	metabolic	NOUN
admet-625	69	8	constants	constant	NOUN
admet-625	69	9	are	be	AUX
admet-625	69	10	identified	identify	VERB
admet-625	69	11	(	(	PUNCT
admet-625	69	12	with	with	ADP
admet-625	69	13	data	datum	NOUN
admet-625	69	14	from	from	ADP
admet-625	69	15	[	[	X
admet-625	69	16	33	33	NUM
admet-625	69	17	]	]	PUNCT
admet-625	69	18	for	for	ADP
admet-625	69	19	iv	iv	NUM
admet-625	69	20	route	route	NOUN
admet-625	69	21	,	,	PUNCT
admet-625	69	22	[	[	X
admet-625	69	23	34	34	NUM
admet-625	69	24	]	]	PUNCT
admet-625	69	25	and	and	CCONJ
admet-625	69	26	[	[	X
admet-625	69	27	29	29	NUM
admet-625	69	28	]	]	PUNCT
admet-625	69	29	for	for	ADP
admet-625	69	30	po	po	NOUN
admet-625	69	31	,	,	PUNCT
admet-625	69	32	and	and	CCONJ
admet-625	69	33	[	[	X
admet-625	69	34	35	35	NUM
admet-625	69	35	]	]	PUNCT
admet-625	69	36	for	for	ADP
admet-625	69	37	td	td	NOUN
admet-625	69	38	)	)	PUNCT
admet-625	69	39	,	,	PUNCT
admet-625	69	40	a	a	DET
admet-625	69	41	model	model	NOUN
admet-625	69	42	validation	validation	NOUN
admet-625	69	43	with	with	ADP
admet-625	69	44	additional	additional	ADJ
admet-625	69	45	experimental	experimental	ADJ
admet-625	69	46	pharmacokinetic	pharmacokinetic	ADJ
admet-625	69	47	data	datum	NOUN
admet-625	69	48	allows	allow	VERB
admet-625	69	49	assessing	assess	VERB
admet-625	69	50	its	its	PRON
admet-625	69	51	prediction	prediction	NOUN
admet-625	69	52	capability	capability	NOUN
admet-625	69	53	.	.	PUNCT
admet-625	70	1	to	to	PART
admet-625	70	2	do	do	VERB
admet-625	70	3	so	so	ADV
admet-625	70	4	,	,	PUNCT
admet-625	70	5	we	we	PRON
admet-625	70	6	chose	choose	VERB
admet-625	70	7	(	(	PUNCT
admet-625	70	8	i	i	NOUN
admet-625	70	9	)	)	PUNCT
admet-625	70	10	the	the	DET
admet-625	70	11	median	median	ADJ
admet-625	70	12	squared	square	VERB
admet-625	70	13	error	error	NOUN
admet-625	70	14	(	(	PUNCT
admet-625	70	15	mese	mese	NOUN
admet-625	70	16	)	)	PUNCT
admet-625	70	17	(	(	PUNCT
admet-625	70	18	eq	eq	NOUN
admet-625	70	19	.	.	PUNCT
admet-625	71	1	(	(	PUNCT
admet-625	71	2	1	1	NUM
admet-625	71	3	)	)	PUNCT
admet-625	71	4	)	)	PUNCT
admet-625	71	5	over	over	ADP
admet-625	71	6	the	the	DET
admet-625	71	7	mean	mean	ADJ
admet-625	71	8	squared	square	VERB
admet-625	71	9	error	error	NOUN
admet-625	71	10	(	(	PUNCT
admet-625	71	11	mse	mse	NOUN
admet-625	71	12	)	)	PUNCT
admet-625	72	1	[	[	X
admet-625	72	2	27	27	NUM
admet-625	72	3	]	]	PUNCT
admet-625	72	4	for	for	ADP
admet-625	72	5	robustness	robustness	NOUN
admet-625	72	6	reasons	reason	NOUN
admet-625	72	7	,	,	PUNCT
admet-625	72	8	(	(	PUNCT
admet-625	72	9	ii	ii	NOUN
admet-625	72	10	)	)	PUNCT
admet-625	72	11	the	the	DET
admet-625	72	12	difference	difference	NOUN
admet-625	72	13	between	between	ADP
admet-625	72	14	the	the	DET
admet-625	72	15	experimental	experimental	ADJ
admet-625	72	16	area	area	NOUN
admet-625	72	17	under	under	ADP
admet-625	72	18	the	the	DET
admet-625	72	19	curve	curve	NOUN
admet-625	72	20	aucexp	aucexp	NOUN
admet-625	72	21	and	and	CCONJ
admet-625	72	22	the	the	DET
admet-625	72	23	model	model	NOUN
admet-625	72	24	prediction	prediction	NOUN
admet-625	72	25	aucmod	aucmod	PROPN
admet-625	72	26	(	(	PUNCT
admet-625	72	27	[	[	X
admet-625	72	28	28	28	NUM
admet-625	72	29	]	]	X
admet-625	72	30	,	,	PUNCT
admet-625	72	31	eq	eq	NOUN
admet-625	72	32	.	.	PUNCT
admet-625	73	1	(	(	PUNCT
admet-625	73	2	2	2	NUM
admet-625	73	3	)	)	PUNCT
admet-625	73	4	)	)	PUNCT
admet-625	73	5	,	,	PUNCT
admet-625	73	6	and	and	CCONJ
admet-625	73	7	(	(	PUNCT
admet-625	73	8	iii	iii	X
admet-625	73	9	)	)	PUNCT
admet-625	73	10	the	the	DET
admet-625	73	11	difference	difference	NOUN
admet-625	73	12	between	between	ADP
admet-625	73	13	the	the	DET
admet-625	73	14	observed	observe	VERB
admet-625	73	15	and	and	CCONJ
admet-625	73	16	predicted	predict	VERB
admet-625	73	17	values	value	NOUN
admet-625	73	18	of	of	ADP
admet-625	73	19	cmax	cmax	NOUN
admet-625	73	20	.	.	PUNCT
admet-625	74	1	comments	comment	NOUN
admet-625	74	2	on	on	ADP
admet-625	74	3	the	the	DET
admet-625	74	4	difference	difference	NOUN
admet-625	74	5	between	between	ADP
admet-625	74	6	the	the	DET
admet-625	74	7	observed	observe	VERB
admet-625	74	8	and	and	CCONJ
admet-625	74	9	predicted	predict	VERB
admet-625	74	10	values	value	NOUN
admet-625	74	11	of	of	ADP
admet-625	74	12	tmax	tmax	ADV
admet-625	74	13	are	be	AUX
admet-625	74	14	also	also	ADV
admet-625	74	15	present	present	ADJ
admet-625	74	16	.	.	PUNCT
admet-625	75	1	the	the	DET
admet-625	75	2	auc	auc	NOUN
admet-625	75	3	is	be	AUX
admet-625	75	4	calculated	calculate	VERB
admet-625	75	5	via	via	ADP
admet-625	75	6	trapezoidal	trapezoidal	ADJ
admet-625	75	7	rule	rule	NOUN
admet-625	75	8	over	over	ADP
admet-625	75	9	the	the	DET
admet-625	75	10	nm	nm	ADV
admet-625	75	11	measured	measure	VERB
admet-625	75	12	concentration	concentration	NOUN
admet-625	75	13	values	value	NOUN
admet-625	75	14	.	.	PUNCT
admet-625	76	1	we	we	PRON
admet-625	76	2	consider	consider	VERB
admet-625	76	3	satisfactory	satisfactory	ADJ
admet-625	76	4	mese	mese	ADJ
admet-625	76	5	values	value	NOUN
admet-625	76	6	below	below	ADP
admet-625	76	7	0.1	0.1	NUM
admet-625	77	1	[	[	X
admet-625	77	2	ng	ng	PROPN
admet-625	77	3	/	/	SYM
admet-625	77	4	ml	ml	NOUN
admet-625	77	5	]	]	PUNCT
admet-625	77	6	and	and	CCONJ
admet-625	77	7	%	%	INTJ
admet-625	77	8	δauc	δauc	ADJ
admet-625	77	9	values	value	NOUN
admet-625	77	10	below	below	ADP
admet-625	77	11	30	30	NUM
admet-625	77	12	%	%	NOUN
admet-625	77	13	.	.	PUNCT
admet-625	78	1			NOUN
admet-625	78	2			ADV
admet-625	78	3			PROPN
admet-625	78	4	2	2	NUM
admet-625	78	5	1	1	NUM
admet-625	78	6	,	,	PUNCT
admet-625	78	7	,	,	PUNCT
admet-625	78	8	exp	exp	NOUN
admet-625	78	9	mod	mod	PROPN
admet-625	78	10	i	i	PRON
admet-625	78	11	imese	imese	VERB
admet-625	78	12	median	median	PROPN
admet-625	79	1	c	c	PROPN
admet-625	79	2	c	c	NOUN
admet-625	80	1	i	i	PRON
admet-625	80	2	nm	nm	PROPN
admet-625	80	3			NOUN
admet-625	80	4			PRON
admet-625	80	5	(	(	PUNCT
admet-625	80	6	1	1	NUM
admet-625	80	7	)	)	PUNCT
admet-625	80	8	%	%	NOUN
admet-625	80	9	100	100	NUM
admet-625	80	10	exp	exp	NOUN
admet-625	80	11	mod	mod	PROPN
admet-625	80	12	auc	auc	NOUN
admet-625	80	13	exp	exp	NOUN
admet-625	80	14	auc	auc	NOUN
admet-625	80	15	auc	auc	NOUN
admet-625	80	16	auc	auc	X
admet-625	80	17			NOUN
admet-625	80	18			NOUN
admet-625	80	19			PROPN
admet-625	80	20			PROPN
admet-625	80	21	(	(	PUNCT
admet-625	80	22	2	2	NUM
admet-625	80	23	)	)	PUNCT
admet-625	80	24	once	once	SCONJ
admet-625	80	25	the	the	DET
admet-625	80	26	prediction	prediction	NOUN
admet-625	80	27	capability	capability	NOUN
admet-625	80	28	of	of	ADP
admet-625	80	29	the	the	DET
admet-625	80	30	pbpk	pbpk	PROPN
admet-625	80	31	model	model	NOUN
admet-625	80	32	is	be	AUX
admet-625	80	33	evaluated	evaluate	VERB
admet-625	80	34	,	,	PUNCT
admet-625	80	35	it	it	PRON
admet-625	80	36	is	be	AUX
admet-625	80	37	interesting	interesting	ADJ
admet-625	80	38	to	to	PART
admet-625	80	39	assess	assess	VERB
admet-625	80	40	in	in	ADP
admet-625	80	41	silico	silico	NOUN
admet-625	80	42	the	the	DET
admet-625	80	43	optimal	optimal	ADJ
admet-625	80	44	administration	administration	NOUN
admet-625	80	45	route	route	NOUN
admet-625	80	46	.	.	PUNCT
admet-625	81	1	in	in	ADP
admet-625	81	2	particular	particular	ADJ
admet-625	81	3	,	,	PUNCT
admet-625	81	4	we	we	PRON
admet-625	81	5	investigated	investigate	VERB
admet-625	81	6	three	three	NUM
admet-625	81	7	distinct	distinct	ADJ
admet-625	81	8	administration	administration	NOUN
admet-625	81	9	routes	route	NOUN
admet-625	81	10	:	:	PUNCT
admet-625	81	11	(	(	PUNCT
admet-625	81	12	i	i	NOUN
admet-625	81	13	)	)	PUNCT
admet-625	81	14	iv	iv	VERB
admet-625	81	15	continuous	continuous	ADJ
admet-625	81	16	infusion	infusion	NOUN
admet-625	81	17	over	over	ADP
admet-625	81	18	7	7	NUM
admet-625	81	19	h	h	NOUN
admet-625	81	20	,	,	PUNCT
admet-625	81	21	(	(	PUNCT
admet-625	81	22	ii	ii	NOUN
admet-625	81	23	)	)	PUNCT
admet-625	81	24	po	po	NOUN
admet-625	81	25	in	in	ADP
admet-625	81	26	both	both	CCONJ
admet-625	81	27	the	the	DET
admet-625	81	28	immediate	immediate	ADJ
admet-625	81	29	and	and	CCONJ
admet-625	81	30	controlled	control	VERB
admet-625	81	31	release	release	NOUN
admet-625	81	32	(	(	PUNCT
admet-625	81	33	cr	cr	NOUN
admet-625	81	34	)	)	PUNCT
admet-625	81	35	formulations	formulation	NOUN
admet-625	81	36	(	(	PUNCT
admet-625	81	37	the	the	DET
admet-625	81	38	last	last	ADJ
admet-625	81	39	one	one	NUM
admet-625	81	40	with	with	ADP
admet-625	81	41	a	a	DET
admet-625	81	42	release	release	NOUN
admet-625	81	43	time	time	NOUN
admet-625	81	44	of	of	ADP
admet-625	81	45	7	7	NUM
admet-625	81	46	h	h	NOUN
admet-625	81	47	)	)	PUNCT
admet-625	81	48	,	,	PUNCT
admet-625	81	49	and	and	CCONJ
admet-625	81	50	(	(	PUNCT
admet-625	81	51	iii	iii	NOUN
admet-625	81	52	)	)	PUNCT
admet-625	81	53	td	td	NOUN
admet-625	81	54	with	with	ADP
admet-625	81	55	a	a	DET
admet-625	81	56	standard	standard	ADJ
admet-625	81	57	patch	patch	NOUN
admet-625	81	58	of	of	ADP
admet-625	81	59	10	10	NUM
admet-625	81	60	cm2	cm2	NOUN
admet-625	81	61	.	.	PUNCT
admet-625	82	1	the	the	DET
admet-625	82	2	po	po	PROPN
admet-625	82	3	(	(	PUNCT
admet-625	82	4	cr	cr	NOUN
admet-625	82	5	)	)	PUNCT
admet-625	82	6	tablet	tablet	NOUN
admet-625	82	7	release	release	NOUN
admet-625	82	8	is	be	AUX
admet-625	82	9	modeled	model	VERB
admet-625	82	10	according	accord	VERB
admet-625	82	11	to	to	ADP
admet-625	82	12	the	the	DET
admet-625	82	13	dissolution	dissolution	ADJ
admet-625	82	14	characteristics	characteristic	NOUN
admet-625	82	15	elucidated	elucidate	VERB
admet-625	82	16	in	in	ADP
admet-625	82	17	[	[	NOUN
admet-625	82	18	36	36	NUM
admet-625	82	19	]	]	PUNCT
admet-625	82	20	and	and	CCONJ
admet-625	82	21	employed	employ	VERB
admet-625	82	22	in	in	ADP
admet-625	82	23	[	[	X
admet-625	82	24	35	35	NUM
admet-625	82	25	]	]	PUNCT
admet-625	82	26	.	.	PUNCT
admet-625	83	1	results	result	NOUN
admet-625	83	2	from	from	ADP
admet-625	83	3	all	all	DET
admet-625	83	4	the	the	DET
admet-625	83	5	administration	administration	NOUN
admet-625	83	6	routes	route	NOUN
admet-625	83	7	are	be	AUX
admet-625	83	8	compared	compare	VERB
admet-625	83	9	for	for	ADP
admet-625	83	10	an	an	DET
admet-625	83	11	assigned	assign	VERB
admet-625	83	12	dose	dose	NOUN
admet-625	83	13	range	range	NOUN
admet-625	83	14	between	between	ADP
admet-625	83	15	0.75	0.75	NUM
admet-625	83	16	-	-	SYM
admet-625	83	17	12	12	NUM
admet-625	83	18	mg	mg	PROPN
admet-625	83	19	,	,	PUNCT
admet-625	83	20	grounding	ground	VERB
admet-625	83	21	on	on	ADP
admet-625	83	22	the	the	DET
admet-625	83	23	state	state	NOUN
admet-625	83	24	-	-	PUNCT
admet-625	83	25	of	of	ADP
admet-625	83	26	-	-	PUNCT
admet-625	83	27	art	art	NOUN
admet-625	83	28	pharmacokinetic	pharmacokinetic	ADJ
admet-625	83	29	studies	study	NOUN
admet-625	83	30	on	on	ADP
admet-625	83	31	exogenous	exogenous	ADJ
admet-625	83	32	melatonin	melatonin	NOUN
admet-625	83	33	administration	administration	NOUN
admet-625	83	34	.	.	PUNCT
admet-625	84	1	for	for	ADP
admet-625	84	2	this	this	DET
admet-625	84	3	preliminary	preliminary	ADJ
admet-625	84	4	study	study	NOUN
admet-625	84	5	,	,	PUNCT
admet-625	84	6	we	we	PRON
admet-625	84	7	do	do	AUX
admet-625	84	8	not	not	PART
admet-625	84	9	consider	consider	VERB
admet-625	84	10	high	high	ADJ
admet-625	84	11	doses	dose	NOUN
admet-625	84	12	[	[	X
admet-625	84	13	37	37	NUM
admet-625	84	14	]	]	PUNCT
admet-625	84	15	.	.	PUNCT
admet-625	85	1	our	our	PRON
admet-625	85	2	virtual	virtual	ADJ
admet-625	85	3	subject	subject	NOUN
admet-625	85	4	is	be	AUX
admet-625	85	5	a	a	DET
admet-625	85	6	healthy	healthy	ADJ
admet-625	85	7	adult	adult	NOUN
admet-625	85	8	male	male	NOUN
admet-625	85	9	of	of	ADP
admet-625	85	10	80	80	NUM
admet-625	85	11	kg	kg	NOUN
admet-625	85	12	and	and	CCONJ
admet-625	85	13	185	185	NUM
admet-625	85	14	cm	cm	NOUN
admet-625	85	15	.	.	PUNCT
admet-625	86	1	to	to	PART
admet-625	86	2	provide	provide	VERB
admet-625	86	3	a	a	DET
admet-625	86	4	quantitative	quantitative	ADJ
admet-625	86	5	comparison	comparison	NOUN
admet-625	86	6	of	of	ADP
admet-625	86	7	the	the	DET
admet-625	86	8	pharmacokinetics	pharmacokinetic	NOUN
admet-625	86	9	resulting	result	VERB
admet-625	86	10	from	from	ADP
admet-625	86	11	the	the	DET
admet-625	86	12	three	three	NUM
admet-625	86	13	administration	administration	NOUN
admet-625	86	14	routes	route	NOUN
admet-625	86	15	,	,	PUNCT
admet-625	86	16	we	we	PRON
admet-625	86	17	calculate	calculate	VERB
admet-625	86	18	and	and	CCONJ
admet-625	86	19	compare	compare	VERB
admet-625	86	20	the	the	DET
admet-625	86	21	auc	auc	NOUN
admet-625	86	22	and	and	CCONJ
admet-625	86	23	the	the	DET
admet-625	86	24	maximum	maximum	ADJ
admet-625	86	25	concentration	concentration	NOUN
admet-625	86	26	cmax	cmax	NOUN
admet-625	86	27	.	.	PUNCT
admet-625	87	1	finally	finally	ADV
admet-625	87	2	,	,	PUNCT
admet-625	87	3	we	we	PRON
admet-625	87	4	comment	comment	VERB
admet-625	87	5	on	on	ADP
admet-625	87	6	the	the	DET
admet-625	87	7	concentration	concentration	NOUN
admet-625	87	8	dynamics	dynamic	NOUN
admet-625	87	9	in	in	ADP
admet-625	87	10	the	the	DET
admet-625	87	11	different	different	ADJ
admet-625	87	12	compartments	compartment	NOUN
admet-625	87	13	of	of	ADP
admet-625	87	14	the	the	DET
admet-625	87	15	body	body	NOUN
admet-625	87	16	that	that	PRON
admet-625	87	17	result	result	VERB
admet-625	87	18	by	by	ADP
admet-625	87	19	simulating	simulate	VERB
admet-625	87	20	the	the	DET
admet-625	87	21	administration	administration	NOUN
admet-625	87	22	of	of	ADP
admet-625	87	23	melatonin	melatonin	NOUN
admet-625	87	24	3	3	NUM
admet-625	87	25	mg	mg	NOUN
admet-625	87	26	via	via	ADP
admet-625	87	27	iv	iv	ADP
admet-625	87	28	,	,	PUNCT
admet-625	87	29	po	po	NOUN
admet-625	87	30	,	,	PUNCT
admet-625	87	31	and	and	CCONJ
admet-625	87	32	td	td	NOUN
admet-625	87	33	routes	route	NOUN
admet-625	87	34	to	to	ADP
admet-625	87	35	the	the	DET
admet-625	87	36	same	same	ADJ
admet-625	87	37	in	in	ADP
admet-625	87	38	silico	silico	NOUN
admet-625	87	39	patient	patient	NOUN
admet-625	87	40	.	.	PUNCT
admet-625	88	1	for	for	ADP
admet-625	88	2	an	an	DET
admet-625	88	3	unbiased	unbiased	ADJ
admet-625	88	4	comparison	comparison	NOUN
admet-625	88	5	of	of	ADP
admet-625	88	6	melatonin	melatonin	NOUN
admet-625	88	7	adme	adme	NOUN
admet-625	88	8	,	,	PUNCT
admet-625	88	9	we	we	PRON
admet-625	88	10	intentionally	intentionally	ADV
admet-625	88	11	neglected	neglect	VERB
admet-625	88	12	the	the	DET
admet-625	88	13	endogenous	endogenous	ADJ
admet-625	88	14	melatonin	melatonin	NOUN
admet-625	88	15	production	production	NOUN
admet-625	88	16	.	.	PUNCT
admet-625	89	1	savoca	savoca	PROPN
admet-625	89	2	and	and	CCONJ
admet-625	89	3	manca	manca	PROPN
admet-625	89	4	admet	admet	PROPN
admet-625	89	5	&	&	CCONJ
admet-625	89	6	dmpk	dmpk	PROPN
admet-625	89	7	7(1	7(1	PROPN
admet-625	89	8	)	)	PUNCT
admet-625	89	9	(	(	PUNCT
admet-625	89	10	2019	2019	NUM
admet-625	89	11	)	)	PUNCT
admet-625	89	12	44	44	NUM
admet-625	89	13	-	-	SYM
admet-625	89	14	59	59	NUM
admet-625	89	15	48	48	NUM
admet-625	89	16	results	result	NOUN
admet-625	89	17	and	and	CCONJ
admet-625	89	18	discussion	discussion	NOUN
admet-625	89	19	we	we	PRON
admet-625	89	20	computed	compute	VERB
admet-625	89	21	the	the	DET
admet-625	89	22	prediction	prediction	NOUN
admet-625	89	23	performance	performance	NOUN
admet-625	89	24	with	with	ADP
admet-625	89	25	data	datum	NOUN
admet-625	89	26	coming	come	VERB
admet-625	89	27	from	from	ADP
admet-625	89	28	melatonin	melatonin	NOUN
admet-625	89	29	pharmacokinetic	pharmacokinetic	ADJ
admet-625	89	30	studies	study	NOUN
admet-625	89	31	.	.	PUNCT
admet-625	90	1	the	the	DET
admet-625	90	2	validation	validation	NOUN
admet-625	90	3	cases	case	NOUN
admet-625	90	4	for	for	ADP
admet-625	90	5	each	each	DET
admet-625	90	6	route	route	NOUN
admet-625	90	7	of	of	ADP
admet-625	90	8	administration	administration	NOUN
admet-625	90	9	are	be	AUX
admet-625	90	10	proposed	propose	VERB
admet-625	90	11	and	and	CCONJ
admet-625	90	12	discussed	discuss	VERB
admet-625	90	13	.	.	PUNCT
admet-625	91	1	iv	iv	NUM
admet-625	91	2	validation	validation	NOUN
admet-625	91	3	case	case	NOUN
admet-625	91	4	figure	figure	NOUN
admet-625	91	5	1	1	NUM
admet-625	91	6	shows	show	VERB
admet-625	91	7	the	the	DET
admet-625	91	8	model	model	NOUN
admet-625	91	9	curve	curve	NOUN
admet-625	91	10	resulting	result	VERB
admet-625	91	11	from	from	ADP
admet-625	91	12	the	the	DET
admet-625	91	13	simulation	simulation	NOUN
admet-625	91	14	of	of	ADP
admet-625	91	15	20	20	NUM
admet-625	91	16	µg	µg	NOUN
admet-625	91	17	iv	iv	NUM
admet-625	91	18	infusion	infusion	NOUN
admet-625	91	19	over	over	ADP
admet-625	91	20	5	5	NUM
admet-625	91	21	h	h	NOUN
admet-625	91	22	to	to	ADP
admet-625	91	23	6	6	NUM
admet-625	91	24	healthy	healthy	ADJ
admet-625	91	25	subjects	subject	NOUN
admet-625	91	26	(	(	PUNCT
admet-625	91	27	a	a	PRON
admet-625	91	28	-	-	PUNCT
admet-625	91	29	f	f	NOUN
admet-625	91	30	panels	panel	NOUN
admet-625	91	31	)	)	PUNCT
admet-625	91	32	and	and	CCONJ
admet-625	91	33	1	1	NUM
admet-625	91	34	individual	individual	NOUN
admet-625	91	35	subjected	subject	VERB
admet-625	91	36	to	to	ADP
admet-625	91	37	pinealectomy	pinealectomy	NOUN
admet-625	91	38	2	2	NUM
admet-625	91	39	years	year	NOUN
admet-625	91	40	earlier	early	ADV
admet-625	91	41	(	(	PUNCT
admet-625	91	42	g	g	PROPN
admet-625	91	43	panel	panel	NOUN
admet-625	91	44	)	)	PUNCT
admet-625	91	45	,	,	PUNCT
admet-625	91	46	as	as	ADP
admet-625	91	47	in	in	ADP
admet-625	91	48	[	[	X
admet-625	91	49	39	39	NUM
admet-625	91	50	]	]	PUNCT
admet-625	91	51	.	.	PUNCT
admet-625	92	1	experimental	experimental	ADJ
admet-625	92	2	data	datum	NOUN
admet-625	92	3	(	(	PUNCT
admet-625	92	4	red	red	ADJ
admet-625	92	5	diamonds	diamond	NOUN
admet-625	92	6	)	)	PUNCT
admet-625	92	7	show	show	VERB
admet-625	92	8	the	the	DET
admet-625	92	9	individual	individual	ADJ
admet-625	92	10	pharmacokinetic	pharmacokinetic	ADJ
admet-625	92	11	profiles	profile	NOUN
admet-625	92	12	.	.	PUNCT
admet-625	93	1	the	the	DET
admet-625	93	2	model	model	NOUN
admet-625	93	3	performance	performance	NOUN
admet-625	93	4	(	(	PUNCT
admet-625	93	5	i.e.	i.e.	X
admet-625	93	6	the	the	DET
admet-625	93	7	blue	blue	ADJ
admet-625	93	8	line	line	NOUN
admet-625	93	9	)	)	PUNCT
admet-625	93	10	is	be	AUX
admet-625	93	11	acceptable	acceptable	ADJ
admet-625	93	12	,	,	PUNCT
admet-625	93	13	but	but	CCONJ
admet-625	93	14	for	for	ADP
admet-625	93	15	a	a	DET
admet-625	93	16	panel	panel	NOUN
admet-625	93	17	of	of	ADP
admet-625	93	18	figure	figure	NOUN
admet-625	93	19	1	1	NUM
admet-625	93	20	.	.	PUNCT
admet-625	94	1	nevertheless	nevertheless	ADV
admet-625	94	2	,	,	PUNCT
admet-625	94	3	the	the	DET
admet-625	94	4	values	value	NOUN
admet-625	94	5	of	of	ADP
admet-625	94	6	the	the	DET
admet-625	94	7	performance	performance	NOUN
admet-625	94	8	indexes	index	NOUN
admet-625	94	9	(	(	PUNCT
admet-625	94	10	see	see	VERB
admet-625	94	11	table	table	NOUN
admet-625	94	12	1	1	NUM
admet-625	94	13	)	)	PUNCT
admet-625	94	14	remain	remain	VERB
admet-625	94	15	quite	quite	ADV
admet-625	94	16	satisfactory	satisfactory	ADJ
admet-625	94	17	,	,	PUNCT
admet-625	94	18	as	as	SCONJ
admet-625	94	19	even	even	ADV
admet-625	94	20	the	the	DET
admet-625	94	21	auc	auc	ADJ
admet-625	94	22	value	value	NOUN
admet-625	94	23	of	of	ADP
admet-625	94	24	that	that	DET
admet-625	94	25	patient	patient	NOUN
admet-625	94	26	(	(	PUNCT
admet-625	94	27	a	a	DET
admet-625	94	28	panel	panel	NOUN
admet-625	94	29	)	)	PUNCT
admet-625	94	30	is	be	AUX
admet-625	94	31	only	only	ADV
admet-625	94	32	slightly	slightly	ADV
admet-625	94	33	higher	high	ADJ
admet-625	94	34	than	than	ADP
admet-625	94	35	30	30	NUM
admet-625	94	36	%	%	NOUN
admet-625	94	37	.	.	PUNCT
admet-625	95	1	it	it	PRON
admet-625	95	2	is	be	AUX
admet-625	95	3	worth	worth	ADJ
admet-625	95	4	observing	observe	VERB
admet-625	95	5	that	that	SCONJ
admet-625	95	6	the	the	DET
admet-625	95	7	experimental	experimental	ADJ
admet-625	95	8	inter	inter	ADJ
admet-625	95	9	-	-	ADJ
admet-625	95	10	individual	individual	ADJ
admet-625	95	11	variability	variability	NOUN
admet-625	95	12	of	of	ADP
admet-625	95	13	melatonin	melatonin	NOUN
admet-625	95	14	levels	level	NOUN
admet-625	95	15	is	be	AUX
admet-625	95	16	reduced	reduce	VERB
admet-625	95	17	in	in	ADP
admet-625	95	18	case	case	NOUN
admet-625	95	19	of	of	ADP
admet-625	95	20	iv	iv	NUM
admet-625	95	21	administration	administration	NOUN
admet-625	95	22	if	if	SCONJ
admet-625	95	23	compared	compare	VERB
admet-625	95	24	to	to	ADP
admet-625	95	25	other	other	ADJ
admet-625	95	26	routes	route	NOUN
admet-625	95	27	(	(	PUNCT
admet-625	95	28	see	see	VERB
admet-625	95	29	also	also	ADV
admet-625	95	30	figure	figure	VERB
admet-625	95	31	2	2	NUM
admet-625	95	32	and	and	CCONJ
admet-625	95	33	figure	figure	VERB
admet-625	95	34	3	3	NUM
admet-625	95	35	)	)	PUNCT
admet-625	95	36	.	.	PUNCT
admet-625	96	1	as	as	ADP
admet-625	96	2	a	a	DET
admet-625	96	3	result	result	NOUN
admet-625	96	4	,	,	PUNCT
admet-625	96	5	also	also	ADV
admet-625	96	6	confidence	confidence	NOUN
admet-625	96	7	intervals	interval	NOUN
admet-625	96	8	of	of	ADP
admet-625	96	9	the	the	DET
admet-625	96	10	iv	iv	NUM
admet-625	96	11	model	model	NOUN
admet-625	96	12	parameters	parameter	NOUN
admet-625	96	13	are	be	AUX
admet-625	96	14	narrower	narrow	ADJ
admet-625	96	15	(	(	PUNCT
admet-625	96	16	see	see	VERB
admet-625	96	17	values	value	NOUN
admet-625	96	18	tables	table	VERB
admet-625	96	19	a	a	DET
admet-625	96	20	-	-	PUNCT
admet-625	96	21	c	c	NOUN
admet-625	96	22	reported	report	VERB
admet-625	96	23	in	in	ADP
admet-625	96	24	appendix	appendix	NOUN
admet-625	96	25	)	)	PUNCT
admet-625	96	26	.	.	PUNCT
admet-625	97	1	figure	figure	NOUN
admet-625	97	2	1	1	NUM
admet-625	97	3	(	(	PUNCT
admet-625	97	4	g	g	PROPN
admet-625	97	5	panel	panel	NOUN
admet-625	97	6	)	)	PUNCT
admet-625	97	7	shows	show	VERB
admet-625	97	8	the	the	DET
admet-625	97	9	experimental	experimental	ADJ
admet-625	97	10	trend	trend	NOUN
admet-625	97	11	for	for	ADP
admet-625	97	12	the	the	DET
admet-625	97	13	pinealectomized	pinealectomize	VERB
admet-625	97	14	patient	patient	NOUN
admet-625	97	15	where	where	SCONJ
admet-625	97	16	the	the	DET
admet-625	97	17	model	model	NOUN
admet-625	97	18	performance	performance	NOUN
admet-625	97	19	is	be	AUX
admet-625	97	20	as	as	ADV
admet-625	97	21	good	good	ADJ
admet-625	97	22	as	as	ADP
admet-625	97	23	for	for	ADP
admet-625	97	24	the	the	DET
admet-625	97	25	others	other	NOUN
admet-625	97	26	.	.	PUNCT
admet-625	98	1	the	the	DET
admet-625	98	2	iv	iv	NUM
admet-625	98	3	model	model	NOUN
admet-625	98	4	was	be	AUX
admet-625	98	5	further	far	ADV
admet-625	98	6	tested	test	VERB
admet-625	98	7	with	with	ADP
admet-625	98	8	experimental	experimental	ADJ
admet-625	98	9	results	result	NOUN
admet-625	98	10	of	of	ADP
admet-625	98	11	additional	additional	ADJ
admet-625	98	12	patients	patient	NOUN
admet-625	98	13	from	from	ADP
admet-625	98	14	the	the	DET
admet-625	98	15	same	same	ADJ
admet-625	98	16	study	study	NOUN
admet-625	98	17	(	(	PUNCT
admet-625	98	18	subjected	subject	VERB
admet-625	98	19	to	to	ADP
admet-625	98	20	bolus	bolus	ADJ
admet-625	98	21	injection	injection	NOUN
admet-625	98	22	)	)	PUNCT
admet-625	98	23	and	and	CCONJ
admet-625	98	24	supplementary	supplementary	ADJ
admet-625	98	25	validation	validation	NOUN
admet-625	98	26	cases	case	NOUN
admet-625	98	27	[	[	X
admet-625	98	28	34,39	34,39	NOUN
admet-625	98	29	]	]	X
admet-625	98	30	,	,	PUNCT
admet-625	98	31	for	for	ADP
admet-625	98	32	which	which	PRON
admet-625	98	33	the	the	DET
admet-625	98	34	results	result	NOUN
admet-625	98	35	of	of	ADP
admet-625	98	36	the	the	DET
admet-625	98	37	%	%	NOUN
admet-625	98	38	δauc	δauc	NOUN
admet-625	98	39	,	,	PUNCT
admet-625	98	40	%	%	NOUN
admet-625	98	41	δcmax	δcmax	NOUN
admet-625	98	42	,	,	PUNCT
admet-625	98	43	and	and	CCONJ
admet-625	98	44	mese	mese	ADJ
admet-625	98	45	(	(	PUNCT
admet-625	98	46	not	not	PART
admet-625	98	47	reported	report	VERB
admet-625	98	48	)	)	PUNCT
admet-625	98	49	are	be	AUX
admet-625	98	50	adequate	adequate	ADJ
admet-625	98	51	as	as	ADV
admet-625	98	52	well	well	ADV
admet-625	98	53	.	.	PUNCT
admet-625	99	1	in	in	ADP
admet-625	99	2	this	this	DET
admet-625	99	3	case	case	NOUN
admet-625	99	4	,	,	PUNCT
admet-625	99	5	we	we	PRON
admet-625	99	6	do	do	AUX
admet-625	99	7	not	not	PART
admet-625	99	8	calculate	calculate	VERB
admet-625	99	9	the	the	DET
admet-625	99	10	experimental	experimental	ADJ
admet-625	99	11	/	/	PUNCT
admet-625	99	12	predicted	predict	VERB
admet-625	99	13	tmax	tmax	ADV
admet-625	99	14	and	and	CCONJ
admet-625	99	15	the	the	DET
admet-625	99	16	relative	relative	ADJ
admet-625	99	17	error	error	NOUN
admet-625	99	18	,	,	PUNCT
admet-625	99	19	because	because	SCONJ
admet-625	99	20	in	in	SCONJ
admet-625	99	21	case	case	NOUN
admet-625	99	22	of	of	ADP
admet-625	99	23	iv	iv	NUM
admet-625	99	24	constant	constant	ADJ
admet-625	99	25	rate	rate	NOUN
admet-625	99	26	of	of	ADP
admet-625	99	27	infusion	infusion	NOUN
admet-625	99	28	the	the	DET
admet-625	99	29	tmax	tmax	ADJ
admet-625	99	30	corresponds	correspond	VERB
admet-625	99	31	to	to	ADP
admet-625	99	32	the	the	DET
admet-625	99	33	infusion	infusion	NOUN
admet-625	99	34	duration	duration	NOUN
admet-625	99	35	(	(	PUNCT
admet-625	99	36	i.e.	i.e.	X
admet-625	99	37	in	in	ADP
admet-625	99	38	this	this	DET
admet-625	99	39	case	case	NOUN
admet-625	99	40	study	study	NOUN
admet-625	99	41	,	,	PUNCT
admet-625	99	42	equal	equal	ADJ
admet-625	99	43	to	to	ADP
admet-625	99	44	5	5	NUM
admet-625	99	45	h	h	NOUN
admet-625	99	46	)	)	PUNCT
admet-625	99	47	.	.	PUNCT
admet-625	100	1	table	table	NOUN
admet-625	100	2	1	1	NUM
admet-625	100	3	performance	performance	NOUN
admet-625	100	4	indexes	index	NOUN
admet-625	100	5	%	%	NOUN
admet-625	100	6	δauc	δauc	ADV
admet-625	101	1	,	,	PUNCT
admet-625	101	2	%	%	INTJ
admet-625	101	3	δcmax	δcmax	VERB
admet-625	101	4	,	,	PUNCT
admet-625	101	5	and	and	CCONJ
admet-625	101	6	mese	mese	ADJ
admet-625	101	7	values	value	NOUN
admet-625	101	8	for	for	ADP
admet-625	101	9	the	the	DET
admet-625	101	10	iv	iv	NUM
admet-625	101	11	validation	validation	NOUN
admet-625	101	12	case	case	NOUN
admet-625	101	13	.	.	PUNCT
admet-625	102	1	patient	patient	ADJ
admet-625	102	2	%	%	NOUN
admet-625	102	3	auc	auc	ADJ
admet-625	102	4	%	%	NOUN
admet-625	102	5	maxc	maxc	PROPN
admet-625	102	6	mese	mese	NOUN
admet-625	102	7	a	a	DET
admet-625	102	8	31.2	31.2	NUM
admet-625	102	9	32.1	32.1	NUM
admet-625	102	10	2.4e-4	2.4e-4	NOUN
admet-625	102	11	b	b	NOUN
admet-625	102	12	18.8	18.8	NUM
admet-625	102	13	24.5	24.5	NUM
admet-625	102	14	2.6e-4	2.6e-4	NUM
admet-625	102	15	c	c	NOUN
admet-625	102	16	14.2	14.2	NUM
admet-625	102	17	13.4	13.4	NUM
admet-625	102	18	4.6e-5	4.6e-5	NUM
admet-625	102	19	d	d	NOUN
admet-625	102	20	20.6	20.6	NUM
admet-625	102	21	10.1	10.1	NUM
admet-625	102	22	8.3e-5	8.3e-5	NUM
admet-625	102	23	e	e	NOUN
admet-625	102	24	10.5	10.5	NUM
admet-625	102	25	10.4	10.4	NUM
admet-625	102	26	2.0e-5	2.0e-5	NUM
admet-625	102	27	f	f	PROPN
admet-625	102	28	16.3	16.3	NUM
admet-625	102	29	31.8	31.8	NUM
admet-625	102	30	4.5e-5	4.5e-5	NUM
admet-625	102	31	g	g	NOUN
admet-625	102	32	0.7	0.7	NUM
admet-625	102	33	6.4	6.4	NUM
admet-625	102	34	5.1e-5	5.1e-5	NUM
admet-625	102	35	po	po	NOUN
admet-625	102	36	validation	validation	NOUN
admet-625	102	37	case	case	NOUN
admet-625	102	38	figure	figure	NOUN
admet-625	102	39	2	2	NUM
admet-625	102	40	shows	show	VERB
admet-625	102	41	experimental	experimental	ADJ
admet-625	102	42	results	result	NOUN
admet-625	102	43	on	on	ADP
admet-625	102	44	melatonin	melatonin	NOUN
admet-625	102	45	concentration	concentration	NOUN
admet-625	102	46	in	in	ADP
admet-625	102	47	case	case	NOUN
admet-625	102	48	of	of	ADP
admet-625	102	49	po	po	PROPN
admet-625	102	50	administration	administration	NOUN
admet-625	102	51	.	.	PUNCT
admet-625	103	1	the	the	DET
admet-625	103	2	blue	blue	ADJ
admet-625	103	3	line	line	NOUN
admet-625	103	4	in	in	ADP
admet-625	103	5	figure	figure	NOUN
admet-625	103	6	2	2	NUM
admet-625	103	7	(	(	PUNCT
admet-625	103	8	a	a	DET
admet-625	103	9	and	and	CCONJ
admet-625	103	10	b	b	NOUN
admet-625	103	11	panels	panel	NOUN
admet-625	103	12	)	)	PUNCT
admet-625	103	13	simulates	simulate	VERB
admet-625	103	14	the	the	DET
admet-625	103	15	pharmacokinetics	pharmacokinetic	NOUN
admet-625	103	16	after	after	ADP
admet-625	103	17	administration	administration	NOUN
admet-625	103	18	of	of	ADP
admet-625	103	19	2	2	NUM
admet-625	103	20	and	and	CCONJ
admet-625	103	21	4	4	NUM
admet-625	103	22	mg	mg	NOUN
admet-625	103	23	respectively	respectively	ADV
admet-625	103	24	,	,	PUNCT
admet-625	103	25	to	to	ADP
admet-625	103	26	12	12	NUM
admet-625	103	27	healthy	healthy	ADJ
admet-625	103	28	volunteers	volunteer	NOUN
admet-625	103	29	[	[	X
admet-625	103	30	33	33	NUM
admet-625	103	31	]	]	PUNCT
admet-625	103	32	.	.	PUNCT
admet-625	104	1	the	the	DET
admet-625	104	2	experimental	experimental	ADJ
admet-625	104	3	data	datum	NOUN
admet-625	104	4	(	(	PUNCT
admet-625	104	5	red	red	ADJ
admet-625	104	6	diamonds	diamond	NOUN
admet-625	104	7	)	)	PUNCT
admet-625	104	8	show	show	NOUN
admet-625	104	9	mean	mean	VERB
admet-625	104	10	concentration	concentration	NOUN
admet-625	104	11	values	value	NOUN
admet-625	104	12	of	of	ADP
admet-625	104	13	the	the	DET
admet-625	104	14	volunteers	volunteer	NOUN
admet-625	104	15	group	group	NOUN
admet-625	104	16	.	.	PUNCT
admet-625	105	1	figure	figure	NOUN
admet-625	105	2	2	2	NUM
admet-625	105	3	(	(	PUNCT
admet-625	105	4	c	c	PROPN
admet-625	105	5	panel	panel	NOUN
admet-625	105	6	)	)	PUNCT
admet-625	105	7	shows	show	VERB
admet-625	105	8	both	both	PRON
admet-625	105	9	individual	individual	ADJ
admet-625	105	10	(	(	PUNCT
admet-625	105	11	red	red	ADJ
admet-625	105	12	dots	dot	NOUN
admet-625	105	13	)	)	PUNCT
admet-625	105	14	and	and	CCONJ
admet-625	105	15	median	median	ADJ
admet-625	105	16	(	(	PUNCT
admet-625	105	17	black	black	ADJ
admet-625	105	18	diamonds	diamond	NOUN
admet-625	105	19	)	)	PUNCT
admet-625	105	20	concentration	concentration	NOUN
admet-625	105	21	profiles	profile	NOUN
admet-625	105	22	of	of	ADP
admet-625	105	23	5	5	NUM
admet-625	105	24	healthy	healthy	ADJ
admet-625	105	25	subjects	subject	NOUN
admet-625	105	26	administered	administer	VERB
admet-625	105	27	with	with	ADP
admet-625	105	28	50	50	NUM
admet-625	105	29	mg	mg	NOUN
admet-625	106	1	[	[	X
admet-625	106	2	25	25	NUM
admet-625	106	3	]	]	PUNCT
admet-625	106	4	.	.	PUNCT
admet-625	107	1	finally	finally	ADV
admet-625	107	2	,	,	PUNCT
admet-625	107	3	figure	figure	VERB
admet-625	107	4	2	2	NUM
admet-625	107	5	(	(	PUNCT
admet-625	107	6	d	d	PROPN
admet-625	107	7	panel	panel	NOUN
admet-625	107	8	)	)	PUNCT
admet-625	107	9	shows	show	VERB
admet-625	107	10	the	the	DET
admet-625	107	11	simulation	simulation	NOUN
admet-625	107	12	(	(	PUNCT
admet-625	107	13	blue	blue	ADJ
admet-625	107	14	line	line	NOUN
admet-625	107	15	)	)	PUNCT
admet-625	107	16	of	of	ADP
admet-625	107	17	the	the	DET
admet-625	107	18	averaged	average	VERB
admet-625	107	19	profile	profile	NOUN
admet-625	107	20	of	of	ADP
admet-625	107	21	5	5	NUM
admet-625	107	22	healthy	healthy	ADJ
admet-625	107	23	subjects	subject	NOUN
admet-625	107	24	administered	administer	VERB
admet-625	107	25	with	with	ADP
admet-625	107	26	2	2	NUM
admet-625	107	27	mg	mg	NOUN
admet-625	108	1	[	[	X
admet-625	108	2	40	40	NUM
admet-625	108	3	]	]	PUNCT
admet-625	108	4	.	.	PUNCT
admet-625	109	1	in	in	ADP
admet-625	109	2	all	all	DET
admet-625	109	3	these	these	DET
admet-625	109	4	cases	case	NOUN
admet-625	109	5	,	,	PUNCT
admet-625	109	6	only	only	ADV
admet-625	109	7	a	a	DET
admet-625	109	8	single	single	ADJ
admet-625	109	9	curve	curve	NOUN
admet-625	109	10	is	be	AUX
admet-625	109	11	displayed	display	VERB
admet-625	109	12	,	,	PUNCT
admet-625	109	13	because	because	SCONJ
admet-625	109	14	the	the	DET
admet-625	109	15	literature	literature	NOUN
admet-625	109	16	data	data	PROPN
admet-625	109	17	report	report	NOUN
admet-625	109	18	only	only	ADV
admet-625	109	19	averaged	average	VERB
admet-625	109	20	demographic	demographic	ADJ
admet-625	109	21	and/or	and/or	CCONJ
admet-625	109	22	pharmacokinetic	pharmacokinetic	ADJ
admet-625	109	23	data	datum	NOUN
admet-625	109	24	.	.	PUNCT
admet-625	110	1	despite	despite	SCONJ
admet-625	110	2	the	the	DET
admet-625	110	3	literature	literature	NOUN
admet-625	110	4	differences	difference	NOUN
admet-625	110	5	in	in	ADP
admet-625	110	6	features	feature	NOUN
admet-625	110	7	and	and	CCONJ
admet-625	110	8	dosages	dosage	NOUN
admet-625	110	9	,	,	PUNCT
admet-625	110	10	the	the	DET
admet-625	110	11	model	model	NOUN
admet-625	110	12	performance	performance	NOUN
admet-625	110	13	is	be	AUX
admet-625	110	14	acceptable	acceptable	ADJ
admet-625	110	15	as	as	SCONJ
admet-625	110	16	the	the	DET
admet-625	110	17	simulation	simulation	NOUN
admet-625	110	18	curve	curve	NOUN
admet-625	110	19	is	be	AUX
admet-625	110	20	near	near	ADJ
admet-625	110	21	to	to	ADP
admet-625	110	22	the	the	DET
admet-625	110	23	average	average	ADJ
admet-625	110	24	experimental	experimental	ADJ
admet-625	110	25	profile	profile	NOUN
admet-625	110	26	in	in	ADP
admet-625	110	27	all	all	DET
admet-625	110	28	the	the	DET
admet-625	110	29	cases	case	NOUN
admet-625	110	30	.	.	PUNCT
admet-625	111	1	in	in	ADP
admet-625	111	2	fact	fact	NOUN
admet-625	111	3	,	,	PUNCT
admet-625	111	4	table	table	NOUN
admet-625	111	5	2	2	NUM
admet-625	111	6	lists	list	NOUN
admet-625	111	7	low	low	ADJ
admet-625	111	8	values	value	NOUN
admet-625	111	9	of	of	ADP
admet-625	111	10	mese	mese	NOUN
admet-625	111	11	,	,	PUNCT
admet-625	111	12	except	except	SCONJ
admet-625	111	13	for	for	ADP
admet-625	111	14	figure	figure	NOUN
admet-625	111	15	2	2	NUM
admet-625	111	16	(	(	PUNCT
admet-625	111	17	c	c	NOUN
admet-625	111	18	panel	panel	NOUN
admet-625	111	19	)	)	PUNCT
admet-625	111	20	.	.	PUNCT
admet-625	112	1	admet	admet	PROPN
admet-625	112	2	&	&	CCONJ
admet-625	112	3	dmpk	dmpk	PROPN
admet-625	112	4	7(1	7(1	PROPN
admet-625	112	5	)	)	PUNCT
admet-625	112	6	(	(	PUNCT
admet-625	112	7	2019	2019	NUM
admet-625	112	8	)	)	PUNCT
admet-625	112	9	44	44	NUM
admet-625	112	10	-	-	SYM
admet-625	112	11	59	59	NUM
admet-625	112	12	pbpk	pbpk	ADJ
admet-625	112	13	simulation	simulation	NOUN
admet-625	112	14	in	in	ADP
admet-625	112	15	pharmacotherapy	pharmacotherapy	NOUN
admet-625	112	16	doi	doi	NOUN
admet-625	112	17	:	:	PUNCT
admet-625	112	18	10.5599	10.5599	NUM
admet-625	112	19	/	/	SYM
admet-625	112	20	admet.625	admet.625	NUM
admet-625	112	21	49	49	NUM
admet-625	112	22	figure	figure	NOUN
admet-625	112	23	1	1	NUM
admet-625	112	24	experimental	experimental	ADJ
admet-625	112	25	data	datum	NOUN
admet-625	112	26	(	(	PUNCT
admet-625	112	27	red	red	ADJ
admet-625	112	28	diamonds	diamond	NOUN
admet-625	112	29	,	,	PUNCT
admet-625	112	30	[	[	X
admet-625	112	31	37	37	NUM
admet-625	112	32	]	]	PUNCT
admet-625	112	33	)	)	PUNCT
admet-625	112	34	represent	represent	VERB
admet-625	112	35	the	the	DET
admet-625	112	36	pharmacokinetics	pharmacokinetic	NOUN
admet-625	112	37	of	of	ADP
admet-625	112	38	6	6	NUM
admet-625	112	39	healthy	healthy	ADJ
admet-625	112	40	subjects	subject	NOUN
admet-625	112	41	(	(	PUNCT
admet-625	112	42	a	a	PRON
admet-625	112	43	-	-	PUNCT
admet-625	112	44	f	f	NOUN
admet-625	112	45	panels	panel	NOUN
admet-625	112	46	)	)	PUNCT
admet-625	112	47	and	and	CCONJ
admet-625	112	48	1	1	NUM
admet-625	112	49	pinealectomized	pinealectomize	VERB
admet-625	112	50	patient	patient	NOUN
admet-625	112	51	(	(	PUNCT
admet-625	112	52	g	g	PROPN
admet-625	112	53	panel	panel	NOUN
admet-625	112	54	)	)	PUNCT
admet-625	112	55	who	who	PRON
admet-625	112	56	received	receive	VERB
admet-625	112	57	iv	iv	NUM
admet-625	112	58	20	20	NUM
admet-625	112	59	µg	µg	ADV
admet-625	112	60	infused	infuse	VERB
admet-625	112	61	over	over	ADP
admet-625	112	62	5	5	NUM
admet-625	112	63	h.	h.	NOUN
admet-625	112	64	the	the	DET
admet-625	112	65	blue	blue	ADJ
admet-625	112	66	continuous	continuous	ADJ
admet-625	112	67	line	line	NOUN
admet-625	112	68	is	be	AUX
admet-625	112	69	the	the	DET
admet-625	112	70	model	model	NOUN
admet-625	112	71	-	-	PUNCT
admet-625	112	72	simulated	simulate	VERB
admet-625	112	73	pharmacokinetic	pharmacokinetic	ADJ
admet-625	112	74	profile	profile	NOUN
admet-625	112	75	.	.	PUNCT
admet-625	113	1	savoca	savoca	PROPN
admet-625	113	2	and	and	CCONJ
admet-625	113	3	manca	manca	PROPN
admet-625	113	4	admet	admet	PROPN
admet-625	113	5	&	&	CCONJ
admet-625	113	6	dmpk	dmpk	PROPN
admet-625	113	7	7(1	7(1	PROPN
admet-625	113	8	)	)	PUNCT
admet-625	113	9	(	(	PUNCT
admet-625	113	10	2019	2019	NUM
admet-625	113	11	)	)	PUNCT
admet-625	113	12	44	44	NUM
admet-625	113	13	-	-	SYM
admet-625	113	14	59	59	NUM
admet-625	113	15	50	50	NUM
admet-625	113	16	it	it	PRON
admet-625	113	17	is	be	AUX
admet-625	113	18	worth	worth	ADJ
admet-625	113	19	observing	observe	VERB
admet-625	113	20	that	that	SCONJ
admet-625	113	21	the	the	DET
admet-625	113	22	simulated	simulated	ADJ
admet-625	113	23	profile	profile	NOUN
admet-625	113	24	(	(	PUNCT
admet-625	113	25	i.e.	i.e.	X
admet-625	113	26	blue	blue	ADJ
admet-625	113	27	line	line	NOUN
admet-625	113	28	)	)	PUNCT
admet-625	113	29	anticipates	anticipate	VERB
admet-625	113	30	the	the	DET
admet-625	113	31	experimental	experimental	ADJ
admet-625	113	32	data	datum	NOUN
admet-625	113	33	(	(	PUNCT
admet-625	113	34	see	see	VERB
admet-625	113	35	figure	figure	NOUN
admet-625	113	36	2	2	NUM
admet-625	113	37	(	(	PUNCT
admet-625	113	38	a	a	DET
admet-625	113	39	,	,	PUNCT
admet-625	113	40	b	b	NOUN
admet-625	113	41	,	,	PUNCT
admet-625	113	42	and	and	CCONJ
admet-625	113	43	c	c	NOUN
admet-625	113	44	panels	panel	NOUN
admet-625	113	45	)	)	PUNCT
admet-625	113	46	)	)	PUNCT
admet-625	113	47	.	.	PUNCT
admet-625	114	1	the	the	DET
admet-625	114	2	difference	difference	NOUN
admet-625	114	3	between	between	ADP
admet-625	114	4	the	the	DET
admet-625	114	5	observed	observe	VERB
admet-625	114	6	and	and	CCONJ
admet-625	114	7	predicted	predict	VERB
admet-625	114	8	tmax	tmax	ADV
admet-625	114	9	is	be	AUX
admet-625	114	10	about	about	ADV
admet-625	114	11	30	30	NUM
admet-625	114	12	min	min	NOUN
admet-625	114	13	.	.	PUNCT
admet-625	115	1	this	this	PRON
admet-625	115	2	may	may	AUX
admet-625	115	3	be	be	AUX
admet-625	115	4	related	relate	VERB
admet-625	115	5	to	to	ADP
admet-625	115	6	digestion	digestion	NOUN
admet-625	115	7	features	feature	NOUN
admet-625	115	8	and	and	CCONJ
admet-625	115	9	to	to	ADP
admet-625	115	10	the	the	DET
admet-625	115	11	patients	patient	NOUN
admet-625	115	12	’	'	PUNCT
admet-625	115	13	condition	condition	NOUN
admet-625	115	14	(	(	PUNCT
admet-625	115	15	e.g.	e.g.	ADV
admet-625	115	16	,	,	PUNCT
admet-625	115	17	fed	feed	VERB
admet-625	115	18	or	or	CCONJ
admet-625	115	19	fasting	fasting	NOUN
admet-625	115	20	)	)	PUNCT
admet-625	115	21	.	.	PUNCT
admet-625	116	1	future	future	ADJ
admet-625	116	2	work	work	NOUN
admet-625	116	3	should	should	AUX
admet-625	116	4	adapt	adapt	VERB
admet-625	116	5	the	the	DET
admet-625	116	6	po	po	NOUN
admet-625	116	7	model	model	NOUN
admet-625	116	8	to	to	ADP
admet-625	116	9	such	such	ADJ
admet-625	116	10	issues	issue	NOUN
admet-625	116	11	.	.	PUNCT
admet-625	117	1	however	however	ADV
admet-625	117	2	,	,	PUNCT
admet-625	117	3	the	the	DET
admet-625	117	4	observed	observed	ADJ
admet-625	117	5	tmax	tmax	NOUN
admet-625	117	6	depends	depend	VERB
admet-625	117	7	also	also	ADV
admet-625	117	8	on	on	ADP
admet-625	117	9	the	the	DET
admet-625	117	10	experimental	experimental	ADJ
admet-625	117	11	protocol	protocol	NOUN
admet-625	117	12	,	,	PUNCT
admet-625	117	13	and	and	CCONJ
admet-625	117	14	in	in	ADP
admet-625	117	15	particular	particular	ADJ
admet-625	117	16	,	,	PUNCT
admet-625	117	17	on	on	ADP
admet-625	117	18	the	the	DET
admet-625	117	19	blood	blood	NOUN
admet-625	117	20	sampling	sample	VERB
admet-625	117	21	time	time	NOUN
admet-625	117	22	.	.	PUNCT
admet-625	118	1	in	in	ADP
admet-625	118	2	addition	addition	NOUN
admet-625	118	3	,	,	PUNCT
admet-625	118	4	this	this	DET
admet-625	118	5	parameter	parameter	NOUN
admet-625	118	6	is	be	AUX
admet-625	118	7	affected	affect	VERB
admet-625	118	8	by	by	ADP
admet-625	118	9	a	a	DET
admet-625	118	10	certain	certain	ADJ
admet-625	118	11	degree	degree	NOUN
admet-625	118	12	of	of	ADP
admet-625	118	13	experimental	experimental	ADJ
admet-625	118	14	error	error	NOUN
admet-625	118	15	.	.	PUNCT
admet-625	119	1	the	the	DET
admet-625	119	2	%	%	NOUN
admet-625	119	3	δauc	δauc	NOUN
admet-625	119	4	in	in	ADP
admet-625	119	5	table	table	NOUN
admet-625	119	6	2	2	NUM
admet-625	119	7	is	be	AUX
admet-625	119	8	always	always	ADV
admet-625	119	9	below	below	ADP
admet-625	119	10	15	15	NUM
admet-625	119	11	%	%	NOUN
admet-625	119	12	while	while	SCONJ
admet-625	119	13	the	the	DET
admet-625	119	14	relative	relative	ADJ
admet-625	119	15	error	error	NOUN
admet-625	119	16	between	between	ADP
admet-625	119	17	the	the	DET
admet-625	119	18	observed	observe	VERB
admet-625	119	19	and	and	CCONJ
admet-625	119	20	predicted	predict	VERB
admet-625	119	21	cmax	cmax	NOUN
admet-625	119	22	is	be	AUX
admet-625	119	23	below	below	ADP
admet-625	119	24	15	15	NUM
admet-625	119	25	%	%	NOUN
admet-625	119	26	except	except	SCONJ
admet-625	119	27	for	for	ADP
admet-625	119	28	case	case	NOUN
admet-625	119	29	a.	a.	NOUN
admet-625	119	30	it	it	PRON
admet-625	119	31	is	be	AUX
admet-625	119	32	fair	fair	ADJ
admet-625	119	33	to	to	PART
admet-625	119	34	acknowledge	acknowledge	VERB
admet-625	119	35	that	that	SCONJ
admet-625	119	36	the	the	DET
admet-625	119	37	pharmacokinetics	pharmacokinetic	NOUN
admet-625	119	38	resulting	result	VERB
admet-625	119	39	from	from	ADP
admet-625	119	40	the	the	DET
admet-625	119	41	po	po	PROPN
admet-625	119	42	route	route	PROPN
admet-625	119	43	features	feature	VERB
admet-625	119	44	a	a	DET
admet-625	119	45	higher	high	ADJ
admet-625	119	46	degree	degree	NOUN
admet-625	119	47	of	of	ADP
admet-625	119	48	interand	interand	NOUN
admet-625	119	49	intra	intra	ADJ
admet-625	119	50	-	-	ADJ
admet-625	119	51	individual	individual	ADJ
admet-625	119	52	variability	variability	NOUN
admet-625	119	53	compared	compare	VERB
admet-625	119	54	to	to	ADP
admet-625	119	55	the	the	DET
admet-625	119	56	iv	iv	NUM
admet-625	119	57	route	route	NOUN
admet-625	119	58	,	,	PUNCT
admet-625	119	59	because	because	SCONJ
admet-625	119	60	of	of	ADP
admet-625	119	61	several	several	ADJ
admet-625	119	62	interacting	interact	VERB
admet-625	119	63	factors	factor	NOUN
admet-625	119	64	that	that	PRON
admet-625	119	65	affect	affect	VERB
admet-625	119	66	absorption	absorption	NOUN
admet-625	119	67	(	(	PUNCT
admet-625	119	68	e.g.	e.g.	ADV
admet-625	119	69	,	,	PUNCT
admet-625	119	70	ph	ph	ADJ
admet-625	119	71	,	,	PUNCT
admet-625	119	72	stomach	stomach	NOUN
admet-625	119	73	emptying	emptying	NOUN
admet-625	119	74	time	time	NOUN
admet-625	119	75	,	,	PUNCT
admet-625	119	76	intestinal	intestinal	ADJ
admet-625	119	77	transit	transit	NOUN
admet-625	119	78	times	time	NOUN
admet-625	119	79	,	,	PUNCT
admet-625	119	80	and	and	CCONJ
admet-625	119	81	variation	variation	NOUN
admet-625	119	82	of	of	ADP
admet-625	119	83	blood	blood	NOUN
admet-625	119	84	supply	supply	NOUN
admet-625	119	85	to	to	ADP
admet-625	119	86	stomach	stomach	NOUN
admet-625	119	87	and	and	CCONJ
admet-625	119	88	intestine	intestine	VERB
admet-625	119	89	)	)	PUNCT
admet-625	119	90	and	and	CCONJ
admet-625	119	91	metabolism	metabolism	NOUN
admet-625	119	92	(	(	PUNCT
admet-625	119	93	e.g.	e.g.	ADV
admet-625	119	94	,	,	PUNCT
admet-625	119	95	genetic	genetic	ADJ
admet-625	119	96	factors	factor	NOUN
admet-625	119	97	and	and	CCONJ
admet-625	119	98	presence	presence	NOUN
admet-625	119	99	of	of	ADP
admet-625	119	100	diseases	disease	NOUN
admet-625	119	101	)	)	PUNCT
admet-625	119	102	.	.	PUNCT
admet-625	120	1	in	in	ADP
admet-625	120	2	fact	fact	NOUN
admet-625	120	3	,	,	PUNCT
admet-625	120	4	mese	mese	ADJ
admet-625	120	5	results	result	NOUN
admet-625	120	6	for	for	ADP
admet-625	120	7	the	the	DET
admet-625	120	8	iv	iv	NUM
admet-625	120	9	validation	validation	NOUN
admet-625	120	10	cases	case	NOUN
admet-625	120	11	are	be	AUX
admet-625	120	12	at	at	ADV
admet-625	120	13	least	least	ADJ
admet-625	120	14	one	one	NUM
admet-625	120	15	order	order	NOUN
admet-625	120	16	of	of	ADP
admet-625	120	17	magnitude	magnitude	NOUN
admet-625	120	18	lower	low	ADJ
admet-625	120	19	and	and	CCONJ
admet-625	120	20	,	,	PUNCT
admet-625	120	21	consistently	consistently	ADV
admet-625	120	22	,	,	PUNCT
admet-625	120	23	confidence	confidence	NOUN
admet-625	120	24	intervals	interval	NOUN
admet-625	120	25	of	of	ADP
admet-625	120	26	the	the	DET
admet-625	120	27	model	model	NOUN
admet-625	120	28	parameters	parameter	NOUN
admet-625	120	29	are	be	AUX
admet-625	120	30	larger	large	ADJ
admet-625	120	31	(	(	PUNCT
admet-625	120	32	table	table	NOUN
admet-625	120	33	b	b	PROPN
admet-625	120	34	in	in	ADP
admet-625	120	35	appendix	appendix	NOUN
admet-625	120	36	)	)	PUNCT
admet-625	120	37	.	.	PUNCT
admet-625	121	1	additional	additional	ADJ
admet-625	121	2	case	case	NOUN
admet-625	121	3	studies	study	NOUN
admet-625	121	4	are	be	AUX
admet-625	121	5	employed	employ	VERB
admet-625	121	6	for	for	ADP
admet-625	121	7	validation	validation	NOUN
admet-625	121	8	,	,	PUNCT
admet-625	121	9	with	with	ADP
admet-625	121	10	similar	similar	ADJ
admet-625	121	11	results	result	NOUN
admet-625	121	12	in	in	ADP
admet-625	121	13	terms	term	NOUN
admet-625	121	14	of	of	ADP
admet-625	121	15	performance	performance	NOUN
admet-625	121	16	assessment	assessment	NOUN
admet-625	121	17	[	[	X
admet-625	121	18	39	39	NUM
admet-625	121	19	]	]	PUNCT
admet-625	121	20	.	.	PUNCT
admet-625	122	1	figure	figure	VERB
admet-625	122	2	2	2	NUM
admet-625	122	3	a	a	DET
admet-625	122	4	-	-	PUNCT
admet-625	122	5	b	b	NOUN
admet-625	122	6	panels	panel	NOUN
admet-625	122	7	:	:	PUNCT
admet-625	122	8	experimental	experimental	ADJ
admet-625	122	9	data	datum	NOUN
admet-625	122	10	(	(	PUNCT
admet-625	122	11	red	red	ADJ
admet-625	122	12	diamonds	diamond	NOUN
admet-625	122	13	,	,	PUNCT
admet-625	122	14	[	[	X
admet-625	122	15	33	33	NUM
admet-625	122	16	]	]	PUNCT
admet-625	122	17	)	)	PUNCT
admet-625	122	18	,	,	PUNCT
admet-625	122	19	represent	represent	VERB
admet-625	122	20	the	the	DET
admet-625	122	21	average	average	ADJ
admet-625	122	22	pharmacokinetics	pharmacokinetic	NOUN
admet-625	122	23	of	of	ADP
admet-625	122	24	12	12	NUM
admet-625	122	25	subjects	subject	NOUN
admet-625	122	26	administered	administer	VERB
admet-625	122	27	with	with	ADP
admet-625	122	28	melatonin	melatonin	NOUN
admet-625	122	29	po	po	NOUN
admet-625	122	30	2	2	NUM
admet-625	122	31	and	and	CCONJ
admet-625	122	32	4	4	NUM
admet-625	122	33	mg	mg	NUM
admet-625	122	34	.	.	PUNCT
admet-625	123	1	c	c	PROPN
admet-625	123	2	panel	panel	NOUN
admet-625	123	3	:	:	PUNCT
admet-625	123	4	experimental	experimental	ADJ
admet-625	123	5	individual	individual	NOUN
admet-625	123	6	(	(	PUNCT
admet-625	123	7	red	red	ADJ
admet-625	123	8	dots	dot	NOUN
admet-625	123	9	)	)	PUNCT
admet-625	123	10	and	and	CCONJ
admet-625	123	11	median	median	ADJ
admet-625	123	12	(	(	PUNCT
admet-625	123	13	black	black	ADJ
admet-625	123	14	diamonds	diamond	NOUN
admet-625	123	15	)	)	PUNCT
admet-625	123	16	pharmacokinetics	pharmacokinetic	NOUN
admet-625	123	17	after	after	ADP
admet-625	123	18	melatonin	melatonin	NOUN
admet-625	123	19	po	po	PROPN
admet-625	123	20	50	50	NUM
admet-625	123	21	mg	mg	NOUN
admet-625	124	1	[	[	X
admet-625	124	2	25	25	NUM
admet-625	124	3	]	]	PUNCT
admet-625	124	4	.	.	PUNCT
admet-625	125	1	d	d	DET
admet-625	125	2	panel	panel	NOUN
admet-625	125	3	:	:	PUNCT
admet-625	125	4	experimental	experimental	ADJ
admet-625	125	5	data	datum	NOUN
admet-625	125	6	(	(	PUNCT
admet-625	125	7	red	red	ADJ
admet-625	125	8	diamonds	diamond	NOUN
admet-625	125	9	)	)	PUNCT
admet-625	125	10	averaged	average	VERB
admet-625	125	11	over	over	ADP
admet-625	125	12	5	5	NUM
admet-625	125	13	healthy	healthy	ADJ
admet-625	125	14	subjects	subject	NOUN
admet-625	125	15	from	from	ADP
admet-625	125	16	[	[	X
admet-625	125	17	40	40	NUM
admet-625	125	18	]	]	PUNCT
admet-625	125	19	(	(	PUNCT
admet-625	125	20	melatonin	melatonin	NOUN
admet-625	125	21	po	po	NOUN
admet-625	125	22	2	2	NUM
admet-625	125	23	mg	mg	NUM
admet-625	125	24	)	)	PUNCT
admet-625	125	25	.	.	PUNCT
admet-625	126	1	the	the	DET
admet-625	126	2	blue	blue	ADJ
admet-625	126	3	continuous	continuous	ADJ
admet-625	126	4	line	line	NOUN
admet-625	126	5	is	be	AUX
admet-625	126	6	the	the	DET
admet-625	126	7	model	model	NOUN
admet-625	126	8	-	-	PUNCT
admet-625	126	9	simulated	simulate	VERB
admet-625	126	10	pharmacokinetic	pharmacokinetic	ADJ
admet-625	126	11	profile	profile	NOUN
admet-625	126	12	.	.	PUNCT
admet-625	127	1	td	td	NOUN
admet-625	127	2	validation	validation	NOUN
admet-625	127	3	case	case	NOUN
admet-625	127	4	figure	figure	NOUN
admet-625	127	5	3	3	NUM
admet-625	127	6	shows	show	VERB
admet-625	127	7	a	a	DET
admet-625	127	8	validation	validation	NOUN
admet-625	127	9	case	case	NOUN
admet-625	127	10	from	from	ADP
admet-625	127	11	[	[	X
admet-625	127	12	41	41	NUM
admet-625	127	13	]	]	PUNCT
admet-625	127	14	for	for	ADP
admet-625	127	15	the	the	DET
admet-625	127	16	td	td	NOUN
admet-625	127	17	route	route	NOUN
admet-625	127	18	.	.	PUNCT
admet-625	128	1	in	in	ADP
admet-625	128	2	the	the	DET
admet-625	128	3	study	study	NOUN
admet-625	128	4	,	,	PUNCT
admet-625	128	5	melatonin	melatonin	NOUN
admet-625	128	6	was	be	AUX
admet-625	128	7	administered	administer	VERB
admet-625	128	8	2.1	2.1	NUM
admet-625	128	9	mg/12	mg/12	PROPN
admet-625	128	10	cm2	cm2	PROPN
admet-625	128	11	as	as	ADP
admet-625	128	12	td	td	NOUN
admet-625	128	13	patch	patch	NOUN
admet-625	128	14	.	.	PUNCT
admet-625	129	1	since	since	SCONJ
admet-625	129	2	the	the	DET
admet-625	129	3	reported	report	VERB
admet-625	129	4	demographic	demographic	ADJ
admet-625	129	5	data	datum	NOUN
admet-625	129	6	consist	consist	VERB
admet-625	129	7	only	only	ADV
admet-625	129	8	of	of	ADP
admet-625	129	9	averaged	average	VERB
admet-625	129	10	measures	measure	NOUN
admet-625	129	11	over	over	ADP
admet-625	129	12	the	the	DET
admet-625	129	13	subjects	subject	NOUN
admet-625	129	14	’	'	PUNCT
admet-625	129	15	group	group	NOUN
admet-625	129	16	,	,	PUNCT
admet-625	129	17	the	the	DET
admet-625	129	18	model	model	NOUN
admet-625	129	19	curve	curve	NOUN
admet-625	129	20	(	(	PUNCT
admet-625	129	21	blue	blue	ADJ
admet-625	129	22	line	line	NOUN
admet-625	129	23	)	)	PUNCT
admet-625	129	24	is	be	AUX
admet-625	129	25	the	the	DET
admet-625	129	26	pharmacokinetics	pharmacokinetic	NOUN
admet-625	129	27	of	of	ADP
admet-625	129	28	an	an	DET
admet-625	129	29	averaged	averaged	ADJ
admet-625	129	30	individual	individual	NOUN
admet-625	129	31	,	,	PUNCT
admet-625	129	32	while	while	SCONJ
admet-625	129	33	red	red	ADJ
admet-625	129	34	diamonds	diamond	NOUN
admet-625	129	35	represent	represent	VERB
admet-625	129	36	the	the	DET
admet-625	129	37	experimental	experimental	ADJ
admet-625	129	38	values	value	NOUN
admet-625	129	39	of	of	ADP
admet-625	129	40	melatonin	melatonin	NOUN
admet-625	129	41	concentration	concentration	NOUN
admet-625	129	42	of	of	ADP
admet-625	129	43	the	the	DET
admet-625	129	44	individuals	individual	NOUN
admet-625	129	45	who	who	PRON
admet-625	129	46	took	take	VERB
admet-625	129	47	part	part	NOUN
admet-625	129	48	to	to	ADP
admet-625	129	49	admet	admet	PROPN
admet-625	129	50	&	&	CCONJ
admet-625	129	51	dmpk	dmpk	PROPN
admet-625	129	52	7(1	7(1	PROPN
admet-625	129	53	)	)	PUNCT
admet-625	129	54	(	(	PUNCT
admet-625	129	55	2019	2019	NUM
admet-625	129	56	)	)	PUNCT
admet-625	129	57	44	44	NUM
admet-625	129	58	-	-	SYM
admet-625	129	59	59	59	NUM
admet-625	129	60	pbpk	pbpk	ADJ
admet-625	129	61	simulation	simulation	NOUN
admet-625	129	62	in	in	ADP
admet-625	129	63	pharmacotherapy	pharmacotherapy	NOUN
admet-625	129	64	doi	doi	NOUN
admet-625	129	65	:	:	PUNCT
admet-625	129	66	10.5599	10.5599	NUM
admet-625	129	67	/	/	SYM
admet-625	129	68	admet.625	admet.625	NUM
admet-625	129	69	51	51	NUM
admet-625	129	70	the	the	DET
admet-625	129	71	study	study	NOUN
admet-625	129	72	,	,	PUNCT
admet-625	129	73	connected	connect	VERB
admet-625	129	74	with	with	ADP
admet-625	129	75	red	red	ADJ
admet-625	129	76	lines	line	NOUN
admet-625	129	77	for	for	ADP
admet-625	129	78	the	the	DET
admet-625	129	79	sake	sake	NOUN
admet-625	129	80	of	of	ADP
admet-625	129	81	clarity	clarity	NOUN
admet-625	129	82	.	.	PUNCT
admet-625	130	1	the	the	DET
admet-625	130	2	model	model	NOUN
admet-625	130	3	prediction	prediction	NOUN
admet-625	130	4	is	be	AUX
admet-625	130	5	quite	quite	ADV
admet-625	130	6	near	near	ADJ
admet-625	130	7	to	to	ADP
admet-625	130	8	three	three	NUM
admet-625	130	9	out	out	ADP
admet-625	130	10	of	of	ADP
admet-625	130	11	four	four	NUM
admet-625	130	12	individual	individual	ADJ
admet-625	130	13	trends	trend	NOUN
admet-625	130	14	.	.	PUNCT
admet-625	131	1	the	the	DET
admet-625	131	2	most	most	ADV
admet-625	131	3	distant	distant	ADJ
admet-625	131	4	individual	individual	ADJ
admet-625	131	5	trend	trend	NOUN
admet-625	131	6	shows	show	VERB
admet-625	131	7	atypical	atypical	ADJ
admet-625	131	8	pharmacological	pharmacological	ADJ
admet-625	131	9	levels	level	NOUN
admet-625	131	10	,	,	PUNCT
admet-625	131	11	which	which	PRON
admet-625	131	12	may	may	AUX
admet-625	131	13	be	be	AUX
admet-625	131	14	related	relate	VERB
admet-625	131	15	to	to	ADP
admet-625	131	16	either	either	DET
admet-625	131	17	differences	difference	NOUN
admet-625	131	18	in	in	ADP
admet-625	131	19	the	the	DET
admet-625	131	20	skin	skin	NOUN
admet-625	131	21	features	feature	NOUN
admet-625	131	22	of	of	ADP
admet-625	131	23	that	that	DET
admet-625	131	24	specific	specific	ADJ
admet-625	131	25	subject	subject	NOUN
admet-625	131	26	and/or	and/or	CCONJ
admet-625	131	27	melatonin	melatonin	NOUN
admet-625	131	28	dermal	dermal	NOUN
admet-625	131	29	deposition	deposition	NOUN
admet-625	131	30	[	[	X
admet-625	131	31	41	41	NUM
admet-625	131	32	]	]	PUNCT
admet-625	131	33	.	.	PUNCT
admet-625	132	1	this	this	PRON
admet-625	132	2	results	result	VERB
admet-625	132	3	into	into	ADP
admet-625	132	4	a	a	DET
admet-625	132	5	nonsensical	nonsensical	ADJ
admet-625	132	6	value	value	NOUN
admet-625	132	7	of	of	ADP
admet-625	132	8	%	%	NOUN
admet-625	132	9	δauc	δauc	NOUN
admet-625	132	10	(	(	PUNCT
admet-625	132	11	table	table	NOUN
admet-625	132	12	3	3	NUM
admet-625	132	13	)	)	PUNCT
admet-625	132	14	.	.	PUNCT
admet-625	133	1	in	in	ADP
admet-625	133	2	general	general	ADJ
admet-625	133	3	,	,	PUNCT
admet-625	133	4	td	td	ADJ
admet-625	133	5	pharmacokinetic	pharmacokinetic	ADJ
admet-625	133	6	data	datum	NOUN
admet-625	133	7	show	show	VERB
admet-625	133	8	high	high	ADJ
admet-625	133	9	inter	inter	ADJ
admet-625	133	10	-	-	ADJ
admet-625	133	11	individual	individual	ADJ
admet-625	133	12	variability	variability	NOUN
admet-625	133	13	having	have	VERB
admet-625	133	14	to	to	PART
admet-625	133	15	do	do	VERB
admet-625	133	16	with	with	ADP
admet-625	133	17	the	the	DET
admet-625	133	18	process	process	NOUN
admet-625	133	19	of	of	ADP
admet-625	133	20	transdermal	transdermal	ADJ
admet-625	133	21	absorption	absorption	NOUN
admet-625	133	22	[	[	X
admet-625	133	23	41	41	NUM
admet-625	133	24	]	]	PUNCT
admet-625	133	25	.	.	PUNCT
admet-625	134	1	this	this	DET
admet-625	134	2	aspect	aspect	NOUN
admet-625	134	3	is	be	AUX
admet-625	134	4	also	also	ADV
admet-625	134	5	reflected	reflect	VERB
admet-625	134	6	in	in	ADP
admet-625	134	7	the	the	DET
admet-625	134	8	confidence	confidence	NOUN
admet-625	134	9	intervals	interval	NOUN
admet-625	134	10	of	of	ADP
admet-625	134	11	the	the	DET
admet-625	134	12	model	model	NOUN
admet-625	134	13	parameters	parameter	NOUN
admet-625	134	14	(	(	PUNCT
admet-625	134	15	table	table	NOUN
admet-625	134	16	c	c	NOUN
admet-625	134	17	in	in	ADP
admet-625	134	18	appendix	appendix	NOUN
admet-625	134	19	)	)	PUNCT
admet-625	134	20	and	and	CCONJ
admet-625	134	21	in	in	ADP
admet-625	134	22	the	the	DET
admet-625	134	23	variability	variability	NOUN
admet-625	134	24	of	of	ADP
admet-625	134	25	observed	observed	ADJ
admet-625	134	26	cmax	cmax	NOUN
admet-625	134	27	and	and	CCONJ
admet-625	134	28	tmax	tmax	ADP
admet-625	134	29	values	value	NOUN
admet-625	134	30	,	,	PUNCT
admet-625	134	31	although	although	SCONJ
admet-625	134	32	it	it	PRON
admet-625	134	33	should	should	AUX
admet-625	134	34	be	be	AUX
admet-625	134	35	remarked	remark	VERB
admet-625	134	36	that	that	SCONJ
admet-625	134	37	blood	blood	NOUN
admet-625	134	38	sampling	sampling	NOUN
admet-625	134	39	occurred	occur	VERB
admet-625	134	40	every	every	DET
admet-625	134	41	hour	hour	NOUN
admet-625	134	42	.	.	PUNCT
admet-625	135	1	thus	thus	ADV
admet-625	135	2	,	,	PUNCT
admet-625	135	3	it	it	PRON
admet-625	135	4	is	be	AUX
admet-625	135	5	not	not	PART
admet-625	135	6	guaranteed	guarantee	VERB
admet-625	135	7	that	that	SCONJ
admet-625	135	8	the	the	DET
admet-625	135	9	real	real	ADJ
admet-625	135	10	experimental	experimental	ADJ
admet-625	135	11	maximum	maximum	ADJ
admet-625	135	12	value	value	NOUN
admet-625	135	13	corresponds	correspond	VERB
admet-625	135	14	to	to	ADP
admet-625	135	15	the	the	DET
admet-625	135	16	observed	observed	ADJ
admet-625	135	17	cmax	cmax	NOUN
admet-625	135	18	.	.	PUNCT
admet-625	136	1	in	in	ADP
admet-625	136	2	any	any	DET
admet-625	136	3	case	case	NOUN
admet-625	136	4	,	,	PUNCT
admet-625	136	5	the	the	DET
admet-625	136	6	%	%	NOUN
admet-625	136	7	δcmax	δcmax	PROPN
admet-625	136	8	is	be	AUX
admet-625	136	9	around	around	ADV
admet-625	136	10	25	25	NUM
admet-625	136	11	-	-	SYM
admet-625	136	12	30	30	NUM
admet-625	136	13	%	%	NOUN
admet-625	136	14	for	for	ADP
admet-625	136	15	the	the	DET
admet-625	136	16	first	first	ADJ
admet-625	136	17	three	three	NUM
admet-625	136	18	individuals	individual	NOUN
admet-625	136	19	.	.	PUNCT
admet-625	137	1	as	as	ADV
admet-625	137	2	far	far	ADV
admet-625	137	3	as	as	SCONJ
admet-625	137	4	the	the	DET
admet-625	137	5	tmax	tmax	NOUN
admet-625	137	6	is	be	AUX
admet-625	137	7	concerned	concern	VERB
admet-625	137	8	,	,	PUNCT
admet-625	137	9	it	it	PRON
admet-625	137	10	is	be	AUX
admet-625	137	11	worth	worth	ADJ
admet-625	137	12	observing	observe	VERB
admet-625	137	13	that	that	SCONJ
admet-625	137	14	the	the	DET
admet-625	137	15	model	model	NOUN
admet-625	137	16	seems	seem	VERB
admet-625	137	17	to	to	PART
admet-625	137	18	predict	predict	VERB
admet-625	137	19	a	a	DET
admet-625	137	20	slower	slow	ADJ
admet-625	137	21	absorption	absorption	NOUN
admet-625	137	22	compared	compare	VERB
admet-625	137	23	to	to	ADP
admet-625	137	24	the	the	DET
admet-625	137	25	experimental	experimental	ADJ
admet-625	137	26	trend	trend	NOUN
admet-625	137	27	.	.	PUNCT
admet-625	138	1	despite	despite	SCONJ
admet-625	138	2	the	the	DET
admet-625	138	3	high	high	ADJ
admet-625	138	4	values	value	NOUN
admet-625	138	5	of	of	ADP
admet-625	138	6	%	%	NOUN
admet-625	138	7	δauc	δauc	NOUN
admet-625	138	8	,	,	PUNCT
admet-625	138	9	it	it	PRON
admet-625	138	10	is	be	AUX
admet-625	138	11	likely	likely	ADJ
admet-625	138	12	that	that	SCONJ
admet-625	138	13	the	the	DET
admet-625	138	14	reliability	reliability	NOUN
admet-625	138	15	of	of	ADP
admet-625	138	16	the	the	DET
admet-625	138	17	model	model	NOUN
admet-625	138	18	for	for	ADP
admet-625	138	19	this	this	DET
admet-625	138	20	route	route	NOUN
admet-625	138	21	might	might	AUX
admet-625	138	22	further	far	ADV
admet-625	138	23	improve	improve	VERB
admet-625	138	24	by	by	ADP
admet-625	138	25	relying	rely	VERB
admet-625	138	26	on	on	ADP
admet-625	138	27	a	a	DET
admet-625	138	28	higher	high	ADJ
admet-625	138	29	number	number	NOUN
admet-625	138	30	of	of	ADP
admet-625	138	31	experimental	experimental	ADJ
admet-625	138	32	data	datum	NOUN
admet-625	138	33	sets	set	NOUN
admet-625	138	34	for	for	ADP
admet-625	138	35	the	the	DET
admet-625	138	36	identification	identification	NOUN
admet-625	138	37	of	of	ADP
admet-625	138	38	the	the	DET
admet-625	138	39	parameters	parameter	NOUN
admet-625	138	40	.	.	PUNCT
admet-625	139	1	table	table	NOUN
admet-625	139	2	2	2	NUM
admet-625	139	3	performance	performance	NOUN
admet-625	139	4	indexes	index	NOUN
admet-625	139	5	%	%	NOUN
admet-625	139	6	δauc	δauc	ADJ
admet-625	139	7	and	and	CCONJ
admet-625	139	8	mese	mese	ADJ
admet-625	139	9	values	value	NOUN
admet-625	139	10	for	for	ADP
admet-625	139	11	the	the	DET
admet-625	139	12	po	po	PROPN
admet-625	139	13	validation	validation	NOUN
admet-625	139	14	case	case	NOUN
admet-625	139	15	.	.	PUNCT
admet-625	140	1	panel	panel	NOUN
admet-625	140	2	%	%	NOUN
admet-625	140	3	auc	auc	PROPN
admet-625	140	4	%	%	NOUN
admet-625	140	5	maxc	maxc	PROPN
admet-625	140	6	mese	mese	NOUN
admet-625	140	7	a	a	DET
admet-625	140	8	2.6	2.6	NUM
admet-625	140	9	40.1	40.1	NUM
admet-625	140	10	0.009	0.009	NUM
admet-625	140	11	b	b	NOUN
admet-625	140	12	7.3	7.3	NUM
admet-625	140	13	13.5	13.5	NUM
admet-625	140	14	0.103	0.103	NUM
admet-625	140	15	c	c	NOUN
admet-625	140	16	14.3	14.3	NUM
admet-625	140	17	10.7	10.7	NUM
admet-625	140	18	5.68	5.68	NUM
admet-625	140	19	d	d	NOUN
admet-625	140	20	8.4	8.4	NUM
admet-625	140	21	5.0	5.0	NUM
admet-625	140	22	0.004	0.004	NUM
admet-625	140	23	figure	figure	NOUN
admet-625	140	24	3	3	NUM
admet-625	140	25	experimental	experimental	ADJ
admet-625	140	26	data	datum	NOUN
admet-625	140	27	(	(	PUNCT
admet-625	140	28	red	red	ADJ
admet-625	140	29	diamonds	diamond	NOUN
admet-625	140	30	,	,	PUNCT
admet-625	140	31	[	[	X
admet-625	140	32	41	41	NUM
admet-625	140	33	]	]	PUNCT
admet-625	140	34	)	)	PUNCT
admet-625	140	35	are	be	AUX
admet-625	140	36	the	the	DET
admet-625	140	37	individual	individual	ADJ
admet-625	140	38	pharmacokinetic	pharmacokinetic	ADJ
admet-625	140	39	trends	trend	NOUN
admet-625	140	40	,	,	PUNCT
admet-625	140	41	resulting	result	VERB
admet-625	140	42	from	from	ADP
admet-625	140	43	melatonin	melatonin	NOUN
admet-625	140	44	td	td	NOUN
admet-625	140	45	2.1	2.1	NUM
admet-625	140	46	mg	mg	NOUN
admet-625	140	47	over	over	ADP
admet-625	140	48	12	12	NUM
admet-625	140	49	cm	cm	NUM
admet-625	140	50	2	2	NUM
admet-625	140	51	patch	patch	NOUN
admet-625	140	52	administration	administration	NOUN
admet-625	140	53	.	.	PUNCT
admet-625	141	1	the	the	DET
admet-625	141	2	blue	blue	ADJ
admet-625	141	3	continuous	continuous	ADJ
admet-625	141	4	line	line	NOUN
admet-625	141	5	is	be	AUX
admet-625	141	6	the	the	DET
admet-625	141	7	model	model	NOUN
admet-625	141	8	-	-	PUNCT
admet-625	141	9	simulated	simulate	VERB
admet-625	141	10	pharmacokinetic	pharmacokinetic	ADJ
admet-625	141	11	profile	profile	NOUN
admet-625	141	12	of	of	ADP
admet-625	141	13	the	the	DET
admet-625	141	14	averaged	average	VERB
admet-625	141	15	subject	subject	NOUN
admet-625	141	16	.	.	PUNCT
admet-625	142	1	table	table	NOUN
admet-625	142	2	3	3	NUM
admet-625	142	3	performance	performance	NOUN
admet-625	142	4	indexes	index	NOUN
admet-625	142	5	%	%	NOUN
admet-625	142	6	δauc	δauc	ADV
admet-625	142	7	,	,	PUNCT
admet-625	142	8	%	%	NOUN
admet-625	142	9	δcmax	δcmax	VERB
admet-625	142	10	,	,	PUNCT
admet-625	142	11	and	and	CCONJ
admet-625	142	12	mese	mese	ADJ
admet-625	142	13	values	value	NOUN
admet-625	142	14	for	for	ADP
admet-625	142	15	the	the	DET
admet-625	142	16	td	td	NOUN
admet-625	142	17	validation	validation	NOUN
admet-625	142	18	case	case	NOUN
admet-625	142	19	.	.	PUNCT
admet-625	143	1	patient	patient	ADJ
admet-625	143	2	%	%	NOUN
admet-625	143	3	auc	auc	ADJ
admet-625	143	4	%	%	NOUN
admet-625	143	5	maxc	maxc	PROPN
admet-625	143	6	mese	mese	PROPN
admet-625	143	7	1	1	NUM
admet-625	143	8	39.1	39.1	NUM
admet-625	143	9	34.9	34.9	NUM
admet-625	143	10	8.2e-4	8.2e-4	NUM
admet-625	143	11	2	2	NUM
admet-625	143	12	38.1	38.1	NUM
admet-625	143	13	27.7	27.7	NUM
admet-625	143	14	2.1e-4	2.1e-4	NUM
admet-625	143	15	3	3	NUM
admet-625	143	16	26.2	26.2	NUM
admet-625	143	17	23.6	23.6	NUM
admet-625	143	18	5.4e-5	5.4e-5	NUM
admet-625	143	19	4	4	NUM
admet-625	143	20	>	>	SYM
admet-625	143	21	100	100	NUM
admet-625	143	22	>	>	SYM
admet-625	143	23	100	100	NUM
admet-625	143	24	4.0e-3	4.0e-3	NUM
admet-625	143	25	savoca	savoca	NOUN
admet-625	143	26	and	and	CCONJ
admet-625	143	27	manca	manca	PROPN
admet-625	143	28	admet	admet	PROPN
admet-625	143	29	&	&	CCONJ
admet-625	143	30	dmpk	dmpk	PROPN
admet-625	143	31	7(1	7(1	PROPN
admet-625	143	32	)	)	PUNCT
admet-625	143	33	(	(	PUNCT
admet-625	143	34	2019	2019	NUM
admet-625	143	35	)	)	PUNCT
admet-625	143	36	44	44	NUM
admet-625	143	37	-	-	SYM
admet-625	143	38	59	59	NUM
admet-625	143	39	52	52	NUM
admet-625	143	40	for	for	ADP
admet-625	143	41	all	all	DET
admet-625	143	42	the	the	DET
admet-625	143	43	considered	consider	VERB
admet-625	143	44	routes	route	NOUN
admet-625	143	45	(	(	PUNCT
admet-625	143	46	i.e.	i.e.	X
admet-625	143	47	iv	iv	NUM
admet-625	143	48	,	,	PUNCT
admet-625	143	49	po	po	NOUN
admet-625	143	50	,	,	PUNCT
admet-625	143	51	and	and	CCONJ
admet-625	143	52	td	td	NOUN
admet-625	143	53	)	)	PUNCT
admet-625	143	54	,	,	PUNCT
admet-625	143	55	the	the	DET
admet-625	143	56	results	result	NOUN
admet-625	143	57	are	be	AUX
admet-625	143	58	acceptable	acceptable	ADJ
admet-625	143	59	enough	enough	ADV
admet-625	143	60	to	to	PART
admet-625	143	61	continue	continue	VERB
admet-625	143	62	with	with	ADP
admet-625	143	63	the	the	DET
admet-625	143	64	analysis	analysis	NOUN
admet-625	143	65	of	of	ADP
admet-625	143	66	melatonin	melatonin	NOUN
admet-625	143	67	adme	adme	NOUN
admet-625	143	68	in	in	ADP
admet-625	143	69	the	the	DET
admet-625	143	70	body	body	NOUN
admet-625	143	71	as	as	ADP
admet-625	143	72	a	a	DET
admet-625	143	73	function	function	NOUN
admet-625	143	74	of	of	ADP
admet-625	143	75	the	the	DET
admet-625	143	76	different	different	ADJ
admet-625	143	77	administration	administration	NOUN
admet-625	143	78	pathways	pathway	NOUN
admet-625	143	79	.	.	PUNCT
admet-625	144	1	in	in	ADP
admet-625	144	2	silico	silico	NOUN
admet-625	144	3	simulations	simulation	NOUN
admet-625	144	4	for	for	ADP
admet-625	144	5	optimal	optimal	ADJ
admet-625	144	6	dose	dose	NOUN
admet-625	144	7	selection	selection	NOUN
admet-625	144	8	a	a	DET
admet-625	144	9	number	number	NOUN
admet-625	144	10	of	of	ADP
admet-625	144	11	pharmacokinetic	pharmacokinetic	ADJ
admet-625	144	12	studies	study	NOUN
admet-625	144	13	focuses	focus	VERB
admet-625	144	14	on	on	ADP
admet-625	144	15	selecting	select	VERB
admet-625	144	16	the	the	DET
admet-625	144	17	optimal	optimal	ADJ
admet-625	144	18	dose	dose	NOUN
admet-625	144	19	that	that	PRON
admet-625	144	20	produces	produce	VERB
admet-625	144	21	either	either	CCONJ
admet-625	144	22	physiological	physiological	ADJ
admet-625	144	23	(	(	PUNCT
admet-625	144	24	e.g.	e.g.	ADV
admet-625	144	25	,	,	PUNCT
admet-625	144	26	[	[	X
admet-625	144	27	38	38	NUM
admet-625	144	28	]	]	SYM
admet-625	144	29	)	)	PUNCT
admet-625	144	30	or	or	CCONJ
admet-625	144	31	supraphysiological	supraphysiological	ADJ
admet-625	144	32	levels	level	NOUN
admet-625	144	33	.	.	PUNCT
admet-625	145	1	in	in	ADP
admet-625	145	2	fact	fact	NOUN
admet-625	145	3	,	,	PUNCT
admet-625	145	4	while	while	SCONJ
admet-625	145	5	physiological	physiological	ADJ
admet-625	145	6	levels	level	NOUN
admet-625	145	7	can	can	AUX
admet-625	145	8	improve	improve	VERB
admet-625	145	9	sleep	sleep	NOUN
admet-625	145	10	maintenance	maintenance	NOUN
admet-625	145	11	and	and	CCONJ
admet-625	145	12	resynchronize	resynchronize	VERB
admet-625	145	13	circadian	circadian	ADJ
admet-625	145	14	rhythms	rhythm	NOUN
admet-625	145	15	[	[	X
admet-625	145	16	17	17	NUM
admet-625	145	17	]	]	PUNCT
admet-625	145	18	,	,	PUNCT
admet-625	145	19	supraphysiological	supraphysiological	ADJ
admet-625	145	20	levels	level	NOUN
admet-625	145	21	may	may	AUX
admet-625	145	22	produce	produce	VERB
admet-625	145	23	strong	strong	ADJ
admet-625	145	24	antioxidant	antioxidant	ADJ
admet-625	145	25	action	action	NOUN
admet-625	145	26	[	[	X
admet-625	145	27	25	25	NUM
admet-625	145	28	]	]	PUNCT
admet-625	145	29	and	and	CCONJ
admet-625	145	30	analgesic	analgesic	ADJ
admet-625	145	31	effects	effect	NOUN
admet-625	145	32	[	[	X
admet-625	145	33	37	37	NUM
admet-625	145	34	]	]	PUNCT
admet-625	145	35	.	.	PUNCT
admet-625	146	1	to	to	PART
admet-625	146	2	investigate	investigate	VERB
admet-625	146	3	melatonin	melatonin	NOUN
admet-625	146	4	pharmacokinetic	pharmacokinetic	ADJ
admet-625	146	5	properties	property	NOUN
admet-625	146	6	,	,	PUNCT
admet-625	146	7	a	a	DET
admet-625	146	8	few	few	ADJ
admet-625	146	9	studies	study	NOUN
admet-625	146	10	compare	compare	VERB
admet-625	146	11	the	the	DET
admet-625	146	12	in	in	ADP
admet-625	146	13	vivo	vivo	ADJ
admet-625	146	14	results	result	NOUN
admet-625	146	15	of	of	ADP
admet-625	146	16	different	different	ADJ
admet-625	146	17	routes	route	NOUN
admet-625	146	18	of	of	ADP
admet-625	146	19	administration	administration	NOUN
admet-625	146	20	[	[	X
admet-625	146	21	34	34	NUM
admet-625	146	22	]	]	PUNCT
admet-625	146	23	,	,	PUNCT
admet-625	146	24	and/or	and/or	CCONJ
admet-625	146	25	specific	specific	ADJ
admet-625	146	26	populations	population	NOUN
admet-625	146	27	(	(	PUNCT
admet-625	146	28	e.g.	e.g.	ADV
admet-625	146	29	,	,	PUNCT
admet-625	146	30	elderly	elderly	ADJ
admet-625	146	31	[	[	X
admet-625	146	32	26	26	NUM
admet-625	146	33	]	]	PUNCT
admet-625	146	34	,	,	PUNCT
admet-625	146	35	critically	critically	ADV
admet-625	146	36	ills	ill	VERB
admet-625	146	37	[	[	X
admet-625	146	38	24	24	NUM
admet-625	146	39	]	]	PUNCT
admet-625	146	40	,	,	PUNCT
admet-625	146	41	patients	patient	NOUN
admet-625	146	42	suffering	suffer	VERB
admet-625	146	43	from	from	ADP
admet-625	146	44	severe	severe	ADJ
admet-625	146	45	oxidative	oxidative	ADJ
admet-625	146	46	stress	stress	NOUN
admet-625	146	47	[	[	X
admet-625	146	48	25	25	NUM
admet-625	146	49	]	]	PUNCT
admet-625	146	50	)	)	PUNCT
admet-625	146	51	.	.	PUNCT
admet-625	147	1	to	to	PART
admet-625	147	2	prove	prove	VERB
admet-625	147	3	the	the	DET
admet-625	147	4	efficiency	efficiency	NOUN
admet-625	147	5	of	of	ADP
admet-625	147	6	in	in	ADP
admet-625	147	7	silico	silico	NOUN
admet-625	147	8	simulations	simulation	NOUN
admet-625	147	9	within	within	ADP
admet-625	147	10	this	this	DET
admet-625	147	11	context	context	NOUN
admet-625	147	12	,	,	PUNCT
admet-625	147	13	we	we	PRON
admet-625	147	14	compare	compare	VERB
admet-625	147	15	the	the	DET
admet-625	147	16	pharmacokinetic	pharmacokinetic	ADJ
admet-625	147	17	profile	profile	NOUN
admet-625	147	18	resulting	result	VERB
admet-625	147	19	from	from	ADP
admet-625	147	20	three	three	NUM
admet-625	147	21	different	different	ADJ
admet-625	147	22	routes	route	NOUN
admet-625	147	23	,	,	PUNCT
admet-625	147	24	with	with	ADP
admet-625	147	25	doses	dose	NOUN
admet-625	147	26	ranging	range	VERB
admet-625	147	27	from	from	ADP
admet-625	147	28	0.75	0.75	NUM
admet-625	147	29	to	to	ADP
admet-625	147	30	12	12	NUM
admet-625	147	31	mg	mg	NOUN
admet-625	147	32	.	.	PUNCT
admet-625	148	1	the	the	DET
admet-625	148	2	selected	select	VERB
admet-625	148	3	range	range	NOUN
admet-625	148	4	is	be	AUX
admet-625	148	5	considered	consider	VERB
admet-625	148	6	safe	safe	ADJ
admet-625	148	7	as	as	SCONJ
admet-625	148	8	it	it	PRON
admet-625	148	9	has	have	AUX
admet-625	148	10	been	be	AUX
admet-625	148	11	covered	cover	VERB
admet-625	148	12	by	by	ADP
admet-625	148	13	a	a	DET
admet-625	148	14	number	number	NOUN
admet-625	148	15	of	of	ADP
admet-625	148	16	pharmacokinetic	pharmacokinetic	ADJ
admet-625	148	17	studies	study	NOUN
admet-625	148	18	.	.	PUNCT
admet-625	149	1	figure	figure	NOUN
admet-625	149	2	4	4	NUM
admet-625	149	3	shows	show	VERB
admet-625	149	4	the	the	DET
admet-625	149	5	results	result	NOUN
admet-625	149	6	of	of	ADP
admet-625	149	7	the	the	DET
admet-625	149	8	simulations	simulation	NOUN
admet-625	149	9	,	,	PUNCT
admet-625	149	10	along	along	ADP
admet-625	149	11	with	with	ADP
admet-625	149	12	comparison	comparison	NOUN
admet-625	149	13	to	to	ADP
admet-625	149	14	experimental	experimental	ADJ
admet-625	149	15	data	datum	NOUN
admet-625	149	16	of	of	ADP
admet-625	149	17	endogenous	endogenous	ADJ
admet-625	149	18	profile	profile	NOUN
admet-625	149	19	in	in	ADP
admet-625	149	20	healthy	healthy	ADJ
admet-625	149	21	adult	adult	NOUN
admet-625	149	22	volunteers	volunteer	NOUN
admet-625	149	23	from	from	ADP
admet-625	149	24	[	[	X
admet-625	149	25	32	32	NUM
admet-625	149	26	]	]	PUNCT
admet-625	149	27	.	.	PUNCT
admet-625	150	1	as	as	SCONJ
admet-625	150	2	expected	expect	VERB
admet-625	150	3	,	,	PUNCT
admet-625	150	4	smoother	smooth	ADJ
admet-625	150	5	and	and	CCONJ
admet-625	150	6	more	more	ADJ
admet-625	150	7	sustained	sustained	ADJ
admet-625	150	8	levels	level	NOUN
admet-625	150	9	are	be	AUX
admet-625	150	10	achieved	achieve	VERB
admet-625	150	11	via	via	ADP
admet-625	150	12	td	td	NOUN
admet-625	150	13	and	and	CCONJ
admet-625	150	14	po	po	PROPN
admet-625	150	15	(	(	PUNCT
admet-625	150	16	cr	cr	NOUN
admet-625	150	17	)	)	PUNCT
admet-625	150	18	formulations	formulation	NOUN
admet-625	150	19	.	.	PUNCT
admet-625	151	1	the	the	DET
admet-625	151	2	slow	slow	ADJ
admet-625	151	3	absorption	absorption	NOUN
admet-625	151	4	phase	phase	NOUN
admet-625	151	5	,	,	PUNCT
admet-625	151	6	which	which	PRON
admet-625	151	7	is	be	AUX
admet-625	151	8	characteristic	characteristic	ADJ
admet-625	151	9	of	of	ADP
admet-625	151	10	td	td	NOUN
admet-625	151	11	release	release	NOUN
admet-625	151	12	,	,	PUNCT
admet-625	151	13	proves	prove	VERB
admet-625	151	14	particularly	particularly	ADV
admet-625	151	15	suitable	suitable	ADJ
admet-625	151	16	for	for	ADP
admet-625	151	17	mimicking	mimic	VERB
admet-625	151	18	the	the	DET
admet-625	151	19	endogenous	endogenous	ADJ
admet-625	151	20	levels	level	NOUN
admet-625	151	21	produced	produce	VERB
admet-625	151	22	by	by	ADP
admet-625	151	23	the	the	DET
admet-625	151	24	pineal	pineal	NOUN
admet-625	151	25	gland	gland	NOUN
admet-625	151	26	.	.	PUNCT
admet-625	152	1	equally	equally	ADV
admet-625	152	2	,	,	PUNCT
admet-625	152	3	the	the	DET
admet-625	152	4	po	po	PROPN
admet-625	152	5	(	(	PUNCT
admet-625	152	6	cr	cr	NOUN
admet-625	152	7	)	)	PUNCT
admet-625	152	8	solution	solution	NOUN
admet-625	152	9	provides	provide	VERB
admet-625	152	10	sustained	sustained	ADJ
admet-625	152	11	levels	level	NOUN
admet-625	152	12	as	as	ADV
admet-625	152	13	well	well	ADV
admet-625	152	14	(	(	PUNCT
admet-625	152	15	tmax	tmax	ADP
admet-625	152	16	about	about	ADV
admet-625	152	17	4	4	NUM
admet-625	152	18	h	h	NOUN
admet-625	152	19	)	)	PUNCT
admet-625	152	20	,	,	PUNCT
admet-625	152	21	coupled	couple	VERB
admet-625	152	22	with	with	ADP
admet-625	152	23	a	a	DET
admet-625	152	24	steeper	steep	ADJ
admet-625	152	25	absorption	absorption	NOUN
admet-625	152	26	(	(	PUNCT
admet-625	152	27	see	see	VERB
admet-625	152	28	especially	especially	ADV
admet-625	152	29	the	the	DET
admet-625	152	30	case	case	NOUN
admet-625	152	31	of	of	ADP
admet-625	152	32	0.75	0.75	NUM
admet-625	152	33	mg	mg	NOUN
admet-625	152	34	)	)	PUNCT
admet-625	152	35	.	.	PUNCT
admet-625	153	1	this	this	DET
admet-625	153	2	difference	difference	NOUN
admet-625	153	3	in	in	ADP
admet-625	153	4	the	the	DET
admet-625	153	5	velocity	velocity	NOUN
admet-625	153	6	of	of	ADP
admet-625	153	7	absorption	absorption	NOUN
admet-625	153	8	has	have	VERB
admet-625	153	9	to	to	PART
admet-625	153	10	be	be	AUX
admet-625	153	11	considered	consider	VERB
admet-625	153	12	in	in	ADP
admet-625	153	13	the	the	DET
admet-625	153	14	choice	choice	NOUN
admet-625	153	15	of	of	ADP
admet-625	153	16	the	the	DET
admet-625	153	17	administration	administration	NOUN
admet-625	153	18	time	time	NOUN
admet-625	153	19	,	,	PUNCT
admet-625	153	20	as	as	SCONJ
admet-625	153	21	this	this	PRON
admet-625	153	22	will	will	AUX
admet-625	153	23	affect	affect	VERB
admet-625	153	24	the	the	DET
admet-625	153	25	onset	onset	ADJ
admet-625	153	26	time	time	NOUN
admet-625	153	27	of	of	ADP
admet-625	153	28	melatonin	melatonin	NOUN
admet-625	153	29	effects	effect	NOUN
admet-625	153	30	.	.	PUNCT
admet-625	154	1	in	in	ADP
admet-625	154	2	case	case	NOUN
admet-625	154	3	of	of	ADP
admet-625	154	4	po	po	PROPN
admet-625	154	5	(	(	PUNCT
admet-625	154	6	cr	cr	NOUN
admet-625	154	7	)	)	PUNCT
admet-625	154	8	0.75	0.75	NUM
admet-625	154	9	mg	mg	PROPN
admet-625	154	10	administration	administration	NOUN
admet-625	154	11	,	,	PUNCT
admet-625	154	12	shifting	shift	VERB
admet-625	154	13	the	the	DET
admet-625	154	14	time	time	NOUN
admet-625	154	15	of	of	ADP
admet-625	154	16	administration	administration	NOUN
admet-625	154	17	would	would	AUX
admet-625	154	18	allow	allow	VERB
admet-625	154	19	quite	quite	DET
admet-625	154	20	a	a	DET
admet-625	154	21	close	close	ADJ
admet-625	154	22	imitation	imitation	NOUN
admet-625	154	23	of	of	ADP
admet-625	154	24	the	the	DET
admet-625	154	25	endogenous	endogenous	ADJ
admet-625	154	26	profile	profile	NOUN
admet-625	154	27	.	.	PUNCT
admet-625	155	1	the	the	DET
admet-625	155	2	same	same	ADJ
admet-625	155	3	consideration	consideration	NOUN
admet-625	155	4	holds	hold	VERB
admet-625	155	5	for	for	ADP
admet-625	155	6	the	the	DET
admet-625	155	7	case	case	NOUN
admet-625	155	8	of	of	ADP
admet-625	155	9	td	td	NOUN
admet-625	155	10	6	6	NUM
admet-625	155	11	mg	mg	PROPN
admet-625	155	12	administration	administration	NOUN
admet-625	155	13	.	.	PUNCT
admet-625	156	1	thus	thus	ADV
admet-625	156	2	,	,	PUNCT
admet-625	156	3	not	not	PART
admet-625	156	4	only	only	ADV
admet-625	156	5	dosing	dose	VERB
admet-625	156	6	,	,	PUNCT
admet-625	156	7	but	but	CCONJ
admet-625	156	8	also	also	ADV
admet-625	156	9	the	the	DET
admet-625	156	10	time	time	NOUN
admet-625	156	11	of	of	ADP
admet-625	156	12	administration	administration	NOUN
admet-625	156	13	is	be	AUX
admet-625	156	14	a	a	DET
admet-625	156	15	key	key	ADJ
admet-625	156	16	degree	degree	NOUN
admet-625	156	17	of	of	ADP
admet-625	156	18	freedom	freedom	NOUN
admet-625	156	19	in	in	ADP
admet-625	156	20	the	the	DET
admet-625	156	21	problem	problem	NOUN
admet-625	156	22	of	of	ADP
admet-625	156	23	melatonin	melatonin	NOUN
admet-625	156	24	delivery	delivery	NOUN
admet-625	156	25	optimization	optimization	NOUN
admet-625	156	26	to	to	PART
admet-625	156	27	restore	restore	VERB
admet-625	156	28	/	/	SYM
admet-625	156	29	produce	produce	VERB
admet-625	156	30	physiological	physiological	ADJ
admet-625	156	31	levels	level	NOUN
admet-625	156	32	.	.	PUNCT
admet-625	157	1	failing	fail	VERB
admet-625	157	2	in	in	ADP
admet-625	157	3	considering	consider	VERB
admet-625	157	4	this	this	DET
admet-625	157	5	aspect	aspect	NOUN
admet-625	157	6	would	would	AUX
admet-625	157	7	likely	likely	ADV
admet-625	157	8	result	result	VERB
admet-625	157	9	into	into	ADP
admet-625	157	10	unsatisfactory	unsatisfactory	ADJ
admet-625	157	11	outcomes	outcome	NOUN
admet-625	157	12	in	in	ADP
admet-625	157	13	terms	term	NOUN
admet-625	157	14	of	of	ADP
admet-625	157	15	pharmacodynamic	pharmacodynamic	ADJ
admet-625	157	16	effects	effect	NOUN
admet-625	157	17	.	.	PUNCT
admet-625	158	1	in	in	ADP
admet-625	158	2	this	this	DET
admet-625	158	3	sense	sense	NOUN
admet-625	158	4	,	,	PUNCT
admet-625	158	5	pbpk	pbpk	NOUN
admet-625	158	6	simulations	simulation	NOUN
admet-625	158	7	can	can	AUX
admet-625	158	8	be	be	AUX
admet-625	158	9	used	use	VERB
admet-625	158	10	as	as	ADP
admet-625	158	11	a	a	DET
admet-625	158	12	tool	tool	NOUN
admet-625	158	13	for	for	ADP
admet-625	158	14	therapy	therapy	NOUN
admet-625	158	15	design	design	NOUN
admet-625	158	16	,	,	PUNCT
admet-625	158	17	to	to	PART
admet-625	158	18	determine	determine	VERB
admet-625	158	19	the	the	DET
admet-625	158	20	time	time	NOUN
admet-625	158	21	of	of	ADP
admet-625	158	22	administration	administration	NOUN
admet-625	158	23	that	that	SCONJ
admet-625	158	24	more	more	ADV
admet-625	158	25	likely	likely	ADV
admet-625	158	26	leads	lead	VERB
admet-625	158	27	to	to	ADP
admet-625	158	28	the	the	DET
admet-625	158	29	desired	desire	VERB
admet-625	158	30	effects	effect	NOUN
admet-625	158	31	.	.	PUNCT
admet-625	159	1	it	it	PRON
admet-625	159	2	should	should	AUX
admet-625	159	3	also	also	ADV
admet-625	159	4	be	be	AUX
admet-625	159	5	noted	note	VERB
admet-625	159	6	that	that	SCONJ
admet-625	159	7	,	,	PUNCT
admet-625	159	8	although	although	SCONJ
admet-625	159	9	the	the	DET
admet-625	159	10	td	td	NOUN
admet-625	159	11	route	route	NOUN
admet-625	159	12	produces	produce	VERB
admet-625	159	13	sustained	sustained	ADJ
admet-625	159	14	levels	level	NOUN
admet-625	159	15	over	over	ADP
admet-625	159	16	24	24	NUM
admet-625	159	17	h	h	NOUN
admet-625	159	18	,	,	PUNCT
admet-625	159	19	it	it	PRON
admet-625	159	20	is	be	AUX
admet-625	159	21	unlikely	unlikely	ADJ
admet-625	159	22	that	that	SCONJ
admet-625	159	23	the	the	DET
admet-625	159	24	subject	subject	NOUN
admet-625	159	25	will	will	AUX
admet-625	159	26	manifest	manifest	VERB
admet-625	159	27	adverse	adverse	ADJ
admet-625	159	28	effects	effect	NOUN
admet-625	159	29	,	,	PUNCT
admet-625	159	30	for	for	ADP
admet-625	159	31	instance	instance	NOUN
admet-625	159	32	related	relate	VERB
admet-625	159	33	to	to	ADP
admet-625	159	34	sleep	sleep	NOUN
admet-625	159	35	.	.	PUNCT
admet-625	160	1	firstly	firstly	ADV
admet-625	160	2	,	,	PUNCT
admet-625	160	3	levels	level	NOUN
admet-625	160	4	are	be	AUX
admet-625	160	5	quite	quite	ADV
admet-625	160	6	similar	similar	ADJ
admet-625	160	7	to	to	ADP
admet-625	160	8	the	the	DET
admet-625	160	9	endogenous	endogenous	ADJ
admet-625	160	10	pattern	pattern	NOUN
admet-625	160	11	(	(	PUNCT
admet-625	160	12	see	see	VERB
admet-625	160	13	the	the	DET
admet-625	160	14	black	black	ADJ
admet-625	160	15	circles	circle	NOUN
admet-625	160	16	)	)	PUNCT
admet-625	160	17	,	,	PUNCT
admet-625	160	18	and	and	CCONJ
admet-625	160	19	after	after	ADP
admet-625	160	20	about	about	ADV
admet-625	160	21	10	10	NUM
admet-625	160	22	h	h	NOUN
admet-625	160	23	,	,	PUNCT
admet-625	160	24	they	they	PRON
admet-625	160	25	start	start	VERB
admet-625	160	26	decreasing	decrease	VERB
admet-625	160	27	towards	towards	ADP
admet-625	160	28	the	the	DET
admet-625	160	29	daily	daily	ADJ
admet-625	160	30	baseline	baseline	NOUN
admet-625	160	31	(	(	PUNCT
admet-625	160	32	black	black	ADJ
admet-625	160	33	dotted	dotted	ADJ
admet-625	160	34	line	line	NOUN
admet-625	160	35	)	)	PUNCT
admet-625	160	36	.	.	PUNCT
admet-625	161	1	secondly	secondly	ADV
admet-625	161	2	,	,	PUNCT
admet-625	161	3	doses	dose	VERB
admet-625	161	4	up	up	ADV
admet-625	161	5	to	to	PART
admet-625	161	6	3500	3500	NUM
admet-625	161	7	mg	mg	PROPN
admet-625	161	8	(	(	PUNCT
admet-625	161	9	po	po	NOUN
admet-625	161	10	)	)	PUNCT
admet-625	161	11	have	have	AUX
admet-625	161	12	been	be	AUX
admet-625	161	13	administered	administer	VERB
admet-625	161	14	without	without	ADP
admet-625	161	15	any	any	DET
admet-625	161	16	acute	acute	ADJ
admet-625	161	17	adverse	adverse	ADJ
admet-625	161	18	effects	effect	NOUN
admet-625	161	19	and	and	CCONJ
admet-625	161	20	the	the	DET
admet-625	161	21	scientific	scientific	ADJ
admet-625	161	22	literature	literature	NOUN
admet-625	161	23	does	do	AUX
admet-625	161	24	not	not	PART
admet-625	161	25	report	report	VERB
admet-625	161	26	any	any	DET
admet-625	161	27	toxic	toxic	ADJ
admet-625	161	28	threshold	threshold	NOUN
admet-625	161	29	for	for	ADP
admet-625	161	30	melatonin	melatonin	NOUN
admet-625	161	31	dose	dose	VERB
admet-625	161	32	[	[	X
admet-625	161	33	37	37	NUM
admet-625	161	34	]	]	PUNCT
admet-625	161	35	.	.	PUNCT
admet-625	162	1	for	for	ADP
admet-625	162	2	instance	instance	NOUN
admet-625	162	3	,	,	PUNCT
admet-625	162	4	in	in	ADP
admet-625	162	5	[	[	PUNCT
admet-625	162	6	37	37	NUM
admet-625	162	7	]	]	PUNCT
admet-625	162	8	there	there	PRON
admet-625	162	9	is	be	VERB
admet-625	162	10	no	no	DET
admet-625	162	11	evidence	evidence	NOUN
admet-625	162	12	of	of	ADP
admet-625	162	13	sedative	sedative	ADJ
admet-625	162	14	effects	effect	NOUN
admet-625	162	15	for	for	ADP
admet-625	162	16	doses	dose	NOUN
admet-625	162	17	up	up	ADP
admet-625	162	18	to	to	PART
admet-625	162	19	100	100	NUM
admet-625	162	20	mg	mg	PROPN
admet-625	162	21	(	(	PUNCT
admet-625	162	22	iv	iv	NUM
admet-625	162	23	)	)	PUNCT
admet-625	162	24	,	,	PUNCT
admet-625	162	25	which	which	PRON
admet-625	162	26	would	would	AUX
admet-625	162	27	produce	produce	VERB
admet-625	162	28	more	more	ADJ
admet-625	162	29	than	than	ADP
admet-625	162	30	3	3	NUM
admet-625	162	31	-	-	PUNCT
admet-625	162	32	order	order	NOUN
admet-625	162	33	-	-	PUNCT
admet-625	162	34	ofmagnitude	ofmagnitude	NOUN
admet-625	162	35	higher	high	ADJ
admet-625	162	36	levels	level	NOUN
admet-625	162	37	than	than	ADP
admet-625	162	38	those	those	PRON
admet-625	162	39	shown	show	VERB
admet-625	162	40	in	in	ADP
admet-625	162	41	figure	figure	NOUN
admet-625	162	42	4	4	NUM
admet-625	162	43	,	,	PUNCT
admet-625	162	44	case	case	NOUN
admet-625	162	45	12	12	NUM
admet-625	162	46	mg	mg	NOUN
admet-625	162	47	via	via	ADP
admet-625	162	48	td	td	PROPN
admet-625	162	49	route	route	NOUN
admet-625	162	50	(	(	PUNCT
admet-625	162	51	according	accord	VERB
admet-625	162	52	to	to	ADP
admet-625	162	53	our	our	PRON
admet-625	162	54	simulations	simulation	NOUN
admet-625	162	55	and	and	CCONJ
admet-625	162	56	consistently	consistently	ADV
admet-625	162	57	with	with	ADP
admet-625	162	58	experimental	experimental	ADJ
admet-625	162	59	results	result	NOUN
admet-625	162	60	reported	report	VERB
admet-625	162	61	in	in	ADP
admet-625	162	62	the	the	DET
admet-625	162	63	study	study	NOUN
admet-625	162	64	)	)	PUNCT
admet-625	162	65	.	.	PUNCT
admet-625	163	1	predictably	predictably	ADV
admet-625	163	2	,	,	PUNCT
admet-625	163	3	even	even	ADV
admet-625	163	4	low	low	ADJ
admet-625	163	5	doses	dose	NOUN
admet-625	163	6	of	of	ADP
admet-625	163	7	continuous	continuous	ADJ
admet-625	163	8	iv	iv	NUM
admet-625	163	9	infusion	infusion	NOUN
admet-625	163	10	produce	produce	VERB
admet-625	163	11	the	the	DET
admet-625	163	12	highest	high	ADJ
admet-625	163	13	levels	level	NOUN
admet-625	163	14	and	and	CCONJ
admet-625	163	15	bioavailability	bioavailability	NOUN
admet-625	163	16	,	,	PUNCT
admet-625	163	17	thus	thus	ADV
admet-625	163	18	it	it	PRON
admet-625	163	19	is	be	AUX
admet-625	163	20	probably	probably	ADV
admet-625	163	21	the	the	DET
admet-625	163	22	most	most	ADV
admet-625	163	23	appropriate	appropriate	ADJ
admet-625	163	24	mean	mean	NOUN
admet-625	163	25	to	to	PART
admet-625	163	26	reach	reach	VERB
admet-625	163	27	prompt	prompt	ADJ
admet-625	163	28	pharmacological	pharmacological	NOUN
admet-625	163	29	(	(	PUNCT
admet-625	163	30	i.e.	i.e.	X
admet-625	163	31	supraphysiological	supraphysiological	ADJ
admet-625	163	32	)	)	PUNCT
admet-625	163	33	levels	level	NOUN
admet-625	163	34	.	.	PUNCT
admet-625	164	1	in	in	ADP
admet-625	164	2	fact	fact	NOUN
admet-625	164	3	,	,	PUNCT
admet-625	164	4	even	even	ADV
admet-625	164	5	for	for	ADP
admet-625	164	6	the	the	DET
admet-625	164	7	lowest	low	ADJ
admet-625	164	8	dose	dose	NOUN
admet-625	164	9	considered	consider	VERB
admet-625	164	10	(	(	PUNCT
admet-625	164	11	i.e.	i.e.	X
admet-625	164	12	0.75	0.75	NUM
admet-625	164	13	mg	mg	NOUN
admet-625	164	14	)	)	PUNCT
admet-625	164	15	,	,	PUNCT
admet-625	164	16	the	the	DET
admet-625	164	17	resulting	result	VERB
admet-625	164	18	plasma	plasma	NOUN
admet-625	164	19	concentration	concentration	NOUN
admet-625	164	20	is	be	AUX
admet-625	164	21	an	an	DET
admet-625	164	22	order	order	NOUN
admet-625	164	23	of	of	ADP
admet-625	164	24	magnitude	magnitude	NOUN
admet-625	164	25	higher	high	ADJ
admet-625	164	26	than	than	ADP
admet-625	164	27	the	the	DET
admet-625	164	28	endogenous	endogenous	ADJ
admet-625	164	29	one	one	NOUN
admet-625	164	30	(	(	PUNCT
admet-625	164	31	see	see	VERB
admet-625	164	32	black	black	ADJ
admet-625	164	33	circles	circle	NOUN
admet-625	164	34	compared	compare	VERB
admet-625	164	35	to	to	ADP
admet-625	164	36	the	the	DET
admet-625	164	37	blue	blue	ADJ
admet-625	164	38	line	line	NOUN
admet-625	164	39	)	)	PUNCT
admet-625	164	40	.	.	PUNCT
admet-625	165	1	on	on	ADP
admet-625	165	2	the	the	DET
admet-625	165	3	contrary	contrary	NOUN
admet-625	165	4	,	,	PUNCT
admet-625	165	5	td	td	PROPN
admet-625	165	6	administration	administration	NOUN
admet-625	165	7	should	should	AUX
admet-625	165	8	be	be	AUX
admet-625	165	9	excluded	exclude	VERB
admet-625	165	10	for	for	ADP
admet-625	165	11	the	the	DET
admet-625	165	12	purpose	purpose	NOUN
admet-625	165	13	of	of	ADP
admet-625	165	14	producing	produce	VERB
admet-625	165	15	pharmacological	pharmacological	ADJ
admet-625	165	16	levels	level	NOUN
admet-625	165	17	(	(	PUNCT
admet-625	165	18	see	see	VERB
admet-625	165	19	highest	high	ADJ
admet-625	165	20	doses	dose	NOUN
admet-625	165	21	12	12	NUM
admet-625	165	22	mg	mg	NOUN
admet-625	165	23	in	in	ADP
admet-625	165	24	figure	figure	NOUN
admet-625	165	25	4	4	NUM
admet-625	165	26	and	and	CCONJ
admet-625	165	27	cmax	cmax	NOUN
admet-625	165	28	value	value	NOUN
admet-625	165	29	in	in	ADP
admet-625	165	30	figure	figure	NOUN
admet-625	165	31	5	5	NUM
admet-625	165	32	)	)	PUNCT
admet-625	165	33	.	.	PUNCT
admet-625	166	1	figure	figure	NOUN
admet-625	166	2	4	4	NUM
admet-625	166	3	also	also	ADV
admet-625	166	4	shows	show	VERB
admet-625	166	5	that	that	SCONJ
admet-625	166	6	in	in	ADP
admet-625	166	7	case	case	NOUN
admet-625	166	8	of	of	ADP
admet-625	166	9	melatonin	melatonin	NOUN
admet-625	166	10	,	,	PUNCT
admet-625	166	11	po	po	NOUN
admet-625	166	12	immediate	immediate	ADJ
admet-625	166	13	release	release	NOUN
admet-625	166	14	formulation	formulation	NOUN
admet-625	166	15	is	be	AUX
admet-625	166	16	not	not	PART
admet-625	166	17	able	able	ADJ
admet-625	166	18	to	to	PART
admet-625	166	19	produce	produce	VERB
admet-625	166	20	sustained	sustained	ADJ
admet-625	166	21	levels	level	NOUN
admet-625	166	22	.	.	PUNCT
admet-625	167	1	however	however	ADV
admet-625	167	2	,	,	PUNCT
admet-625	167	3	for	for	ADP
admet-625	167	4	doses	dose	NOUN
admet-625	167	5	higher	high	ADJ
admet-625	167	6	than	than	ADP
admet-625	167	7	5	5	NUM
admet-625	167	8	mg	mg	NOUN
admet-625	167	9	,	,	PUNCT
admet-625	167	10	this	this	DET
admet-625	167	11	administration	administration	NOUN
admet-625	167	12	route	route	NOUN
admet-625	167	13	can	can	AUX
admet-625	167	14	be	be	AUX
admet-625	167	15	considered	consider	VERB
admet-625	167	16	to	to	PART
admet-625	167	17	reach	reach	VERB
admet-625	167	18	pharmacological	pharmacological	ADJ
admet-625	167	19	levels	level	NOUN
admet-625	167	20	,	,	PUNCT
admet-625	167	21	alternatively	alternatively	ADV
admet-625	167	22	to	to	AUX
admet-625	167	23	iv	iv	NUM
admet-625	167	24	infusion	infusion	NOUN
admet-625	167	25	.	.	PUNCT
admet-625	168	1	all	all	PRON
admet-625	168	2	of	of	ADP
admet-625	168	3	these	these	DET
admet-625	168	4	considerations	consideration	NOUN
admet-625	168	5	are	be	AUX
admet-625	168	6	confirmed	confirm	VERB
admet-625	168	7	by	by	ADP
admet-625	168	8	the	the	DET
admet-625	168	9	values	value	NOUN
admet-625	168	10	of	of	ADP
admet-625	168	11	the	the	DET
admet-625	168	12	pharmacokinetic	pharmacokinetic	ADJ
admet-625	168	13	parameters	parameter	NOUN
admet-625	168	14	auc	auc	VERB
admet-625	168	15	and	and	CCONJ
admet-625	168	16	cmax	cmax	NOUN
admet-625	168	17	,	,	PUNCT
admet-625	168	18	compared	compare	VERB
admet-625	168	19	in	in	ADP
admet-625	168	20	figure	figure	NOUN
admet-625	168	21	5	5	NUM
admet-625	168	22	.	.	PUNCT
admet-625	169	1	the	the	DET
admet-625	169	2	highest	high	ADJ
admet-625	169	3	auc	auc	NOUN
admet-625	169	4	is	be	AUX
admet-625	169	5	in	in	ADP
admet-625	169	6	fact	fact	NOUN
admet-625	169	7	associated	associate	VERB
admet-625	169	8	with	with	ADP
admet-625	169	9	the	the	DET
admet-625	169	10	iv	iv	NUM
admet-625	169	11	continuous	continuous	ADJ
admet-625	169	12	infusion	infusion	NOUN
admet-625	169	13	route	route	NOUN
admet-625	169	14	,	,	PUNCT
admet-625	169	15	whereas	whereas	SCONJ
admet-625	169	16	admet	admet	PROPN
admet-625	169	17	&	&	CCONJ
admet-625	169	18	dmpk	dmpk	PROPN
admet-625	169	19	7(1	7(1	PROPN
admet-625	169	20	)	)	PUNCT
admet-625	169	21	(	(	PUNCT
admet-625	169	22	2019	2019	NUM
admet-625	169	23	)	)	PUNCT
admet-625	169	24	44	44	NUM
admet-625	169	25	-	-	SYM
admet-625	169	26	59	59	NUM
admet-625	169	27	pbpk	pbpk	ADJ
admet-625	169	28	simulation	simulation	NOUN
admet-625	169	29	in	in	ADP
admet-625	169	30	pharmacotherapy	pharmacotherapy	NOUN
admet-625	169	31	doi	doi	NOUN
admet-625	169	32	:	:	PUNCT
admet-625	169	33	10.5599	10.5599	NUM
admet-625	169	34	/	/	SYM
admet-625	169	35	admet.625	admet.625	NUM
admet-625	169	36	53	53	NUM
admet-625	169	37	the	the	DET
admet-625	169	38	other	other	ADJ
admet-625	169	39	routes	route	NOUN
admet-625	169	40	of	of	ADP
admet-625	169	41	administration	administration	NOUN
admet-625	169	42	produce	produce	VERB
admet-625	169	43	lower	low	ADJ
admet-625	169	44	values	value	NOUN
admet-625	169	45	.	.	PUNCT
admet-625	170	1	another	another	DET
admet-625	170	2	possibility	possibility	NOUN
admet-625	170	3	to	to	PART
admet-625	170	4	be	be	AUX
admet-625	170	5	explored	explore	VERB
admet-625	170	6	is	be	AUX
admet-625	170	7	the	the	DET
admet-625	170	8	combination	combination	NOUN
admet-625	170	9	of	of	ADP
admet-625	170	10	oral	oral	ADJ
admet-625	170	11	immediate	immediate	ADJ
admet-625	170	12	release	release	NOUN
admet-625	170	13	and	and	CCONJ
admet-625	170	14	cr	cr	ADP
admet-625	170	15	formulations	formulation	NOUN
admet-625	170	16	.	.	PUNCT
admet-625	171	1	figure	figure	VERB
admet-625	171	2	4	4	NUM
admet-625	171	3	dynamics	dynamic	NOUN
admet-625	171	4	of	of	ADP
admet-625	171	5	the	the	DET
admet-625	171	6	melatonin	melatonin	NOUN
admet-625	171	7	plasma	plasma	NOUN
admet-625	171	8	concentration	concentration	NOUN
admet-625	171	9	over	over	ADP
admet-625	171	10	24	24	NUM
admet-625	171	11	h	h	NOUN
admet-625	171	12	after	after	ADP
admet-625	171	13	iv	iv	ADP
admet-625	171	14	,	,	PUNCT
admet-625	171	15	po	po	NOUN
admet-625	171	16	,	,	PUNCT
admet-625	171	17	po	po	PROPN
admet-625	171	18	(	(	PUNCT
admet-625	171	19	cr	cr	NOUN
admet-625	171	20	)	)	PUNCT
admet-625	171	21	,	,	PUNCT
admet-625	171	22	and	and	CCONJ
admet-625	171	23	td	td	PROPN
admet-625	171	24	administration	administration	NOUN
admet-625	171	25	of	of	ADP
admet-625	171	26	1.5	1.5	NUM
admet-625	171	27	to	to	PART
admet-625	171	28	12	12	NUM
admet-625	171	29	mg	mg	NOUN
admet-625	171	30	to	to	ADP
admet-625	171	31	a	a	DET
admet-625	171	32	virtual	virtual	ADJ
admet-625	171	33	subject	subject	NOUN
admet-625	171	34	(	(	PUNCT
admet-625	171	35	male	male	NOUN
admet-625	171	36	,	,	PUNCT
admet-625	171	37	adult	adult	NOUN
admet-625	171	38	,	,	PUNCT
admet-625	171	39	80	80	NUM
admet-625	171	40	kg	kg	NOUN
admet-625	171	41	,	,	PUNCT
admet-625	171	42	185	185	NUM
admet-625	171	43	cm	cm	NOUN
admet-625	171	44	)	)	PUNCT
admet-625	171	45	.	.	PUNCT
admet-625	172	1	black	black	ADJ
admet-625	172	2	circles	circle	NOUN
admet-625	172	3	describe	describe	VERB
admet-625	172	4	the	the	DET
admet-625	172	5	endogenous	endogenous	ADJ
admet-625	172	6	profile	profile	NOUN
admet-625	172	7	in	in	ADP
admet-625	172	8	healthy	healthy	ADJ
admet-625	172	9	adult	adult	NOUN
admet-625	172	10	volunteers	volunteer	NOUN
admet-625	172	11	[	[	X
admet-625	172	12	32	32	NUM
admet-625	172	13	]	]	PUNCT
admet-625	172	14	.	.	PUNCT
admet-625	173	1	black	black	ADJ
admet-625	173	2	horizontal	horizontal	PROPN
admet-625	173	3	dashed	dash	VERB
admet-625	173	4	lines	line	NOUN
admet-625	173	5	indicate	indicate	VERB
admet-625	173	6	the	the	DET
admet-625	173	7	range	range	NOUN
admet-625	173	8	of	of	ADP
admet-625	173	9	endogenous	endogenous	ADJ
admet-625	173	10	cmax	cmax	NOUN
admet-625	173	11	in	in	ADP
admet-625	173	12	healthy	healthy	ADJ
admet-625	173	13	subjects	subject	NOUN
admet-625	173	14	(	(	PUNCT
admet-625	173	15	60	60	NUM
admet-625	173	16	-	-	SYM
admet-625	173	17	100	100	NUM
admet-625	173	18	pg	pg	NOUN
admet-625	173	19	/	/	SYM
admet-625	173	20	ml	ml	VERB
admet-625	173	21	)	)	PUNCT
admet-625	173	22	.	.	PUNCT
admet-625	174	1	black	black	ADJ
admet-625	174	2	dotted	dot	VERB
admet-625	174	3	line	line	NOUN
admet-625	174	4	marks	mark	VERB
admet-625	174	5	the	the	DET
admet-625	174	6	average	average	ADJ
admet-625	174	7	value	value	NOUN
admet-625	174	8	of	of	ADP
admet-625	174	9	daily	daily	ADJ
admet-625	174	10	melatonin	melatonin	NOUN
admet-625	174	11	baseline	baseline	VERB
admet-625	174	12	in	in	ADP
admet-625	174	13	plasma	plasma	NOUN
admet-625	174	14	.	.	PUNCT
admet-625	175	1	depending	depend	VERB
admet-625	175	2	on	on	ADP
admet-625	175	3	the	the	DET
admet-625	175	4	treatment	treatment	NOUN
admet-625	175	5	goal	goal	NOUN
admet-625	175	6	,	,	PUNCT
admet-625	175	7	for	for	ADP
admet-625	175	8	instance	instance	NOUN
admet-625	175	9	the	the	DET
admet-625	175	10	attainment	attainment	NOUN
admet-625	175	11	of	of	ADP
admet-625	175	12	either	either	CCONJ
admet-625	175	13	endogenous	endogenous	ADJ
admet-625	175	14	or	or	CCONJ
admet-625	175	15	pharmacological	pharmacological	NOUN
admet-625	175	16	levels	level	NOUN
admet-625	175	17	,	,	PUNCT
admet-625	175	18	it	it	PRON
admet-625	175	19	is	be	AUX
admet-625	175	20	possible	possible	ADJ
admet-625	175	21	to	to	PART
admet-625	175	22	explore	explore	VERB
admet-625	175	23	additional	additional	ADJ
admet-625	175	24	contributing	contributing	NOUN
admet-625	175	25	factors	factor	NOUN
admet-625	175	26	,	,	PUNCT
admet-625	175	27	other	other	ADJ
admet-625	175	28	than	than	ADP
admet-625	175	29	the	the	DET
admet-625	175	30	route	route	NOUN
admet-625	175	31	,	,	PUNCT
admet-625	175	32	dose	dose	NOUN
admet-625	175	33	,	,	PUNCT
admet-625	175	34	and	and	CCONJ
admet-625	175	35	time	time	NOUN
admet-625	175	36	of	of	ADP
admet-625	175	37	administration	administration	NOUN
admet-625	175	38	.	.	PUNCT
admet-625	176	1	in	in	ADP
admet-625	176	2	fact	fact	NOUN
admet-625	176	3	,	,	PUNCT
admet-625	176	4	different	different	ADJ
admet-625	176	5	dissolution	dissolution	NOUN
admet-625	176	6	curves	curve	NOUN
admet-625	176	7	can	can	AUX
admet-625	176	8	be	be	AUX
admet-625	176	9	employed	employ	VERB
admet-625	176	10	in	in	ADP
admet-625	176	11	the	the	DET
admet-625	176	12	po	po	PROPN
admet-625	176	13	(	(	PUNCT
admet-625	176	14	cr	cr	NOUN
admet-625	176	15	)	)	PUNCT
admet-625	176	16	formulations	formulation	NOUN
admet-625	176	17	and	and	CCONJ
admet-625	176	18	can	can	AUX
admet-625	176	19	be	be	AUX
admet-625	176	20	combined	combine	VERB
admet-625	176	21	with	with	ADP
admet-625	176	22	the	the	DET
admet-625	176	23	pbpk	pbpk	PROPN
admet-625	176	24	model	model	NOUN
admet-625	176	25	to	to	PART
admet-625	176	26	study	study	VERB
admet-625	176	27	the	the	DET
admet-625	176	28	resulting	result	VERB
admet-625	176	29	adme	adme	NOUN
admet-625	176	30	processes	process	NOUN
admet-625	176	31	.	.	PUNCT
admet-625	177	1	the	the	DET
admet-625	177	2	same	same	ADJ
admet-625	177	3	approach	approach	NOUN
admet-625	177	4	can	can	AUX
admet-625	177	5	be	be	AUX
admet-625	177	6	applied	apply	VERB
admet-625	177	7	in	in	ADP
admet-625	177	8	case	case	NOUN
admet-625	177	9	of	of	ADP
admet-625	177	10	td	td	NOUN
admet-625	177	11	route	route	NOUN
admet-625	177	12	,	,	PUNCT
admet-625	177	13	since	since	SCONJ
admet-625	177	14	both	both	CCONJ
admet-625	177	15	the	the	DET
admet-625	177	16	features	feature	NOUN
admet-625	177	17	,	,	PUNCT
admet-625	177	18	position	position	NOUN
admet-625	177	19	,	,	PUNCT
admet-625	177	20	and	and	CCONJ
admet-625	177	21	application	application	NOUN
admet-625	177	22	extent	extent	NOUN
admet-625	177	23	of	of	ADP
admet-625	177	24	the	the	DET
admet-625	177	25	patch	patch	NOUN
admet-625	177	26	are	be	AUX
admet-625	177	27	degrees	degree	NOUN
admet-625	177	28	of	of	ADP
admet-625	177	29	freedom	freedom	NOUN
admet-625	177	30	for	for	ADP
admet-625	177	31	the	the	DET
admet-625	177	32	medical	medical	ADJ
admet-625	177	33	doctor	doctor	NOUN
admet-625	177	34	.	.	PUNCT
admet-625	178	1	the	the	DET
admet-625	178	2	main	main	ADJ
admet-625	178	3	degree	degree	NOUN
admet-625	178	4	of	of	ADP
admet-625	178	5	freedom	freedom	NOUN
admet-625	178	6	of	of	ADP
admet-625	178	7	the	the	DET
admet-625	178	8	iv	iv	NUM
admet-625	178	9	infusion	infusion	NOUN
admet-625	178	10	route	route	NOUN
admet-625	178	11	is	be	AUX
admet-625	178	12	its	its	PRON
admet-625	178	13	duration	duration	NOUN
admet-625	178	14	.	.	PUNCT
admet-625	179	1	once	once	ADV
admet-625	179	2	the	the	DET
admet-625	179	3	main	main	ADJ
admet-625	179	4	goal	goal	NOUN
admet-625	179	5	is	be	AUX
admet-625	179	6	assigned	assign	VERB
admet-625	179	7	(	(	PUNCT
admet-625	179	8	in	in	ADP
admet-625	179	9	terms	term	NOUN
admet-625	179	10	of	of	ADP
admet-625	179	11	ideal	ideal	ADJ
admet-625	179	12	pharmacokinetic	pharmacokinetic	ADJ
admet-625	179	13	profile	profile	NOUN
admet-625	179	14	for	for	ADP
admet-625	179	15	a	a	DET
admet-625	179	16	specific	specific	ADJ
admet-625	179	17	application	application	NOUN
admet-625	179	18	)	)	PUNCT
admet-625	179	19	,	,	PUNCT
admet-625	179	20	an	an	DET
admet-625	179	21	optimization	optimization	NOUN
admet-625	179	22	can	can	AUX
admet-625	179	23	be	be	AUX
admet-625	179	24	carried	carry	VERB
admet-625	179	25	out	out	ADP
admet-625	179	26	to	to	PART
admet-625	179	27	identify	identify	VERB
admet-625	179	28	the	the	DET
admet-625	179	29	optimal	optimal	ADJ
admet-625	179	30	dose	dose	NOUN
admet-625	179	31	and	and	CCONJ
admet-625	179	32	dosing	dose	VERB
admet-625	179	33	regimen	regiman	NOUN
admet-625	179	34	by	by	ADP
admet-625	179	35	considering	consider	VERB
admet-625	179	36	those	those	DET
admet-625	179	37	additional	additional	ADJ
admet-625	179	38	degrees	degree	NOUN
admet-625	179	39	of	of	ADP
admet-625	179	40	freedom	freedom	NOUN
admet-625	179	41	.	.	PUNCT
admet-625	180	1	savoca	savoca	PROPN
admet-625	180	2	and	and	CCONJ
admet-625	180	3	manca	manca	PROPN
admet-625	180	4	admet	admet	PROPN
admet-625	180	5	&	&	CCONJ
admet-625	180	6	dmpk	dmpk	PROPN
admet-625	180	7	7(1	7(1	PROPN
admet-625	180	8	)	)	PUNCT
admet-625	180	9	(	(	PUNCT
admet-625	180	10	2019	2019	NUM
admet-625	180	11	)	)	PUNCT
admet-625	180	12	44	44	NUM
admet-625	180	13	-	-	SYM
admet-625	180	14	59	59	NUM
admet-625	180	15	54	54	NUM
admet-625	180	16	figure	figure	NOUN
admet-625	180	17	5	5	NUM
admet-625	180	18	comparison	comparison	NOUN
admet-625	180	19	of	of	ADP
admet-625	180	20	pharmacokinetic	pharmacokinetic	ADJ
admet-625	180	21	parameters	parameter	NOUN
admet-625	180	22	cmax	cmax	VERB
admet-625	180	23	(	(	PUNCT
admet-625	180	24	left	leave	VERB
admet-625	180	25	panel	panel	NOUN
admet-625	180	26	)	)	PUNCT
admet-625	180	27	and	and	CCONJ
admet-625	180	28	auc	auc	NOUN
admet-625	180	29	(	(	PUNCT
admet-625	180	30	right	right	ADJ
admet-625	180	31	panel	panel	NOUN
admet-625	180	32	)	)	PUNCT
admet-625	180	33	resulting	result	VERB
admet-625	180	34	from	from	ADP
admet-625	180	35	the	the	DET
admet-625	180	36	three	three	NUM
admet-625	180	37	routes	route	NOUN
admet-625	180	38	of	of	ADP
admet-625	180	39	administration	administration	NOUN
admet-625	180	40	.	.	PUNCT
admet-625	181	1	the	the	DET
admet-625	181	2	x	x	ADJ
admet-625	181	3	-	-	ADJ
admet-625	181	4	axis	axis	ADJ
admet-625	181	5	reports	report	NOUN
admet-625	181	6	the	the	DET
admet-625	181	7	simulated	simulated	ADJ
admet-625	181	8	dose	dose	NOUN
admet-625	181	9	range	range	NOUN
admet-625	181	10	,	,	PUNCT
admet-625	181	11	i.e.	i.e.	X
admet-625	181	12	0.75	0.75	NUM
admet-625	181	13	to	to	PART
admet-625	181	14	12	12	NUM
admet-625	181	15	mg	mg	NOUN
admet-625	181	16	.	.	PUNCT
admet-625	182	1	since	since	SCONJ
admet-625	182	2	melatonin	melatonin	NOUN
admet-625	182	3	roles	role	NOUN
admet-625	182	4	affect	affect	VERB
admet-625	182	5	several	several	ADJ
admet-625	182	6	organs	organ	NOUN
admet-625	182	7	and	and	CCONJ
admet-625	182	8	tissues	tissue	NOUN
admet-625	182	9	,	,	PUNCT
admet-625	182	10	with	with	ADP
admet-625	182	11	cerebral	cerebral	ADJ
admet-625	182	12	,	,	PUNCT
admet-625	182	13	immune	immune	ADJ
admet-625	182	14	,	,	PUNCT
admet-625	182	15	gastrointestinal	gastrointestinal	ADJ
admet-625	182	16	,	,	PUNCT
admet-625	182	17	cardiovascular	cardiovascular	ADJ
admet-625	182	18	,	,	PUNCT
admet-625	182	19	renal	renal	ADJ
admet-625	182	20	,	,	PUNCT
admet-625	182	21	and	and	CCONJ
admet-625	182	22	endocrine	endocrine	NOUN
admet-625	182	23	functions	function	NOUN
admet-625	182	24	[	[	X
admet-625	182	25	12	12	NUM
admet-625	182	26	]	]	PUNCT
admet-625	182	27	,	,	PUNCT
admet-625	182	28	and	and	CCONJ
admet-625	182	29	melatonin	melatonin	NOUN
admet-625	182	30	receptors	receptor	NOUN
admet-625	182	31	are	be	AUX
admet-625	182	32	distributed	distribute	VERB
admet-625	182	33	in	in	ADP
admet-625	182	34	the	the	DET
admet-625	182	35	whole	whole	ADJ
admet-625	182	36	body	body	NOUN
admet-625	182	37	,	,	PUNCT
admet-625	182	38	model	model	NOUN
admet-625	182	39	compartment	compartment	NOUN
admet-625	182	40	levels	level	NOUN
admet-625	182	41	should	should	AUX
admet-625	182	42	be	be	AUX
admet-625	182	43	visualized	visualize	VERB
admet-625	182	44	and	and	CCONJ
admet-625	182	45	discussed	discuss	VERB
admet-625	182	46	,	,	PUNCT
admet-625	182	47	as	as	ADV
admet-625	182	48	well	well	ADV
admet-625	182	49	.	.	PUNCT
admet-625	183	1	figure	figure	NOUN
admet-625	183	2	6	6	NUM
admet-625	183	3	shows	show	VERB
admet-625	183	4	the	the	DET
admet-625	183	5	simulation	simulation	NOUN
admet-625	183	6	in	in	ADP
admet-625	183	7	different	different	ADJ
admet-625	183	8	compartments	compartment	NOUN
admet-625	183	9	for	for	ADP
admet-625	183	10	3	3	NUM
admet-625	183	11	mg	mg	NOUN
admet-625	183	12	administered	administer	VERB
admet-625	183	13	iv	iv	NUM
admet-625	183	14	,	,	PUNCT
admet-625	183	15	po	po	NOUN
admet-625	183	16	,	,	PUNCT
admet-625	183	17	po	po	PROPN
admet-625	183	18	(	(	PUNCT
admet-625	183	19	cr	cr	NOUN
admet-625	183	20	)	)	PUNCT
admet-625	183	21	,	,	PUNCT
admet-625	183	22	and	and	CCONJ
admet-625	183	23	td	td	NOUN
admet-625	183	24	.	.	PUNCT
admet-625	184	1	the	the	DET
admet-625	184	2	slow	slow	ADJ
admet-625	184	3	drug	drug	NOUN
admet-625	184	4	absorption	absorption	NOUN
admet-625	184	5	,	,	PUNCT
admet-625	184	6	typical	typical	ADJ
admet-625	184	7	of	of	ADP
admet-625	184	8	td	td	PROPN
admet-625	184	9	administration	administration	NOUN
admet-625	184	10	,	,	PUNCT
admet-625	184	11	is	be	AUX
admet-625	184	12	reflected	reflect	VERB
admet-625	184	13	in	in	ADP
admet-625	184	14	the	the	DET
admet-625	184	15	slow	slow	ADJ
admet-625	184	16	distribution	distribution	NOUN
admet-625	184	17	to	to	ADP
admet-625	184	18	the	the	DET
admet-625	184	19	organs	organ	NOUN
admet-625	184	20	/	/	SYM
admet-625	184	21	tissues	tissue	NOUN
admet-625	184	22	of	of	ADP
admet-625	184	23	the	the	DET
admet-625	184	24	body	body	NOUN
admet-625	184	25	.	.	PUNCT
admet-625	185	1	conversely	conversely	ADV
admet-625	185	2	,	,	PUNCT
admet-625	185	3	iv	iv	NUM
admet-625	185	4	infusion	infusion	NOUN
admet-625	185	5	induces	induce	VERB
admet-625	185	6	higher	high	ADJ
admet-625	185	7	levels	level	NOUN
admet-625	185	8	in	in	ADP
admet-625	185	9	all	all	DET
admet-625	185	10	the	the	DET
admet-625	185	11	compartments	compartment	NOUN
admet-625	185	12	(	(	PUNCT
admet-625	185	13	see	see	VERB
admet-625	185	14	highly	highly	ADV
admet-625	185	15	perfused	perfused	ADJ
admet-625	185	16	organs	organ	NOUN
admet-625	185	17	and	and	CCONJ
admet-625	185	18	liver	liver	NOUN
admet-625	185	19	compartments	compartment	NOUN
admet-625	185	20	in	in	ADP
admet-625	185	21	figure	figure	NOUN
admet-625	185	22	6	6	NUM
admet-625	185	23	)	)	PUNCT
admet-625	185	24	.	.	PUNCT
admet-625	186	1	thus	thus	ADV
admet-625	186	2	,	,	PUNCT
admet-625	186	3	in	in	ADP
admet-625	186	4	case	case	NOUN
admet-625	186	5	the	the	DET
admet-625	186	6	goal	goal	NOUN
admet-625	186	7	of	of	ADP
admet-625	186	8	melatonin	melatonin	PROPN
admet-625	186	9	administration	administration	NOUN
admet-625	186	10	is	be	AUX
admet-625	186	11	a	a	DET
admet-625	186	12	diffused	diffused	ADJ
admet-625	186	13	anti	anti	ADJ
admet-625	186	14	-	-	ADJ
admet-625	186	15	oxidant	oxidant	ADJ
admet-625	186	16	action	action	NOUN
admet-625	186	17	in	in	ADP
admet-625	186	18	the	the	DET
admet-625	186	19	patient	patient	ADJ
admet-625	186	20	body	body	NOUN
admet-625	186	21	via	via	ADP
admet-625	186	22	radicals	radical	NOUN
admet-625	186	23	scavenging	scavenge	VERB
admet-625	186	24	,	,	PUNCT
admet-625	186	25	this	this	DET
admet-625	186	26	route	route	NOUN
admet-625	186	27	should	should	AUX
admet-625	186	28	be	be	AUX
admet-625	186	29	preferred	prefer	VERB
admet-625	186	30	.	.	PUNCT
admet-625	187	1	the	the	DET
admet-625	187	2	same	same	ADJ
admet-625	187	3	can	can	AUX
admet-625	187	4	be	be	AUX
admet-625	187	5	stated	state	VERB
admet-625	187	6	in	in	ADP
admet-625	187	7	case	case	NOUN
admet-625	187	8	of	of	ADP
admet-625	187	9	immune	immune	ADJ
admet-625	187	10	system	system	NOUN
admet-625	187	11	enhancement	enhancement	NOUN
admet-625	187	12	(	(	PUNCT
admet-625	187	13	hence	hence	ADV
admet-625	187	14	with	with	ADP
admet-625	187	15	potential	potential	ADJ
admet-625	187	16	beneficial	beneficial	ADJ
admet-625	187	17	effects	effect	NOUN
admet-625	187	18	in	in	ADP
admet-625	187	19	terms	term	NOUN
admet-625	187	20	of	of	ADP
admet-625	187	21	cancer	cancer	NOUN
admet-625	187	22	cells	cell	NOUN
admet-625	187	23	detection	detection	NOUN
admet-625	187	24	and	and	CCONJ
admet-625	187	25	elimination	elimination	NOUN
admet-625	187	26	)	)	PUNCT
admet-625	187	27	.	.	PUNCT
admet-625	188	1	in	in	ADP
admet-625	188	2	addition	addition	NOUN
admet-625	188	3	,	,	PUNCT
admet-625	188	4	when	when	SCONJ
admet-625	188	5	target	target	NOUN
admet-625	188	6	organs	organ	NOUN
admet-625	188	7	are	be	AUX
admet-625	188	8	the	the	DET
admet-625	188	9	highly	highly	ADV
admet-625	188	10	perfused	perfused	ADJ
admet-625	188	11	ones	one	NOUN
admet-625	188	12	(	(	PUNCT
admet-625	188	13	e.g.	e.g.	ADV
admet-625	188	14	,	,	PUNCT
admet-625	188	15	pancreas	pancrea	NOUN
admet-625	188	16	,	,	PUNCT
admet-625	188	17	liver	liver	NOUN
admet-625	188	18	,	,	PUNCT
admet-625	188	19	and	and	CCONJ
admet-625	188	20	kidneys	kidney	NOUN
admet-625	188	21	)	)	PUNCT
admet-625	188	22	,	,	PUNCT
admet-625	188	23	this	this	DET
admet-625	188	24	route	route	NOUN
admet-625	188	25	should	should	AUX
admet-625	188	26	be	be	AUX
admet-625	188	27	definitely	definitely	ADV
admet-625	188	28	considered	consider	VERB
admet-625	188	29	.	.	PUNCT
admet-625	189	1	when	when	SCONJ
admet-625	189	2	a	a	DET
admet-625	189	3	more	more	ADV
admet-625	189	4	localized	localized	ADJ
admet-625	189	5	target	target	NOUN
admet-625	189	6	action	action	NOUN
admet-625	189	7	is	be	AUX
admet-625	189	8	required	require	VERB
admet-625	189	9	,	,	PUNCT
admet-625	189	10	it	it	PRON
admet-625	189	11	should	should	AUX
admet-625	189	12	be	be	AUX
admet-625	189	13	considered	consider	VERB
admet-625	189	14	that	that	SCONJ
admet-625	189	15	in	in	ADP
admet-625	189	16	case	case	NOUN
admet-625	189	17	of	of	ADP
admet-625	189	18	po	po	PROPN
admet-625	189	19	administration	administration	PROPN
admet-625	189	20	,	,	PUNCT
admet-625	189	21	higher	high	ADJ
admet-625	189	22	levels	level	NOUN
admet-625	189	23	are	be	AUX
admet-625	189	24	expected	expect	VERB
admet-625	189	25	in	in	ADP
admet-625	189	26	the	the	DET
admet-625	189	27	liver	liver	NOUN
admet-625	189	28	and	and	CCONJ
admet-625	189	29	gastrointestinal	gastrointestinal	ADJ
admet-625	189	30	tract	tract	NOUN
admet-625	189	31	,	,	PUNCT
admet-625	189	32	as	as	SCONJ
admet-625	189	33	confirmed	confirm	VERB
admet-625	189	34	by	by	ADP
admet-625	189	35	the	the	DET
admet-625	189	36	model	model	NOUN
admet-625	189	37	simulation	simulation	PROPN
admet-625	189	38	.	.	PUNCT
admet-625	190	1	according	accord	VERB
admet-625	190	2	to	to	ADP
admet-625	190	3	[	[	X
admet-625	190	4	14	14	NUM
admet-625	190	5	]	]	PUNCT
admet-625	190	6	,	,	PUNCT
admet-625	190	7	melatonin	melatonin	NOUN
admet-625	190	8	is	be	AUX
admet-625	190	9	gastroprotective	gastroprotective	ADJ
admet-625	190	10	at	at	ADP
admet-625	190	11	endogenous	endogenous	ADJ
admet-625	190	12	levels	level	NOUN
admet-625	190	13	,	,	PUNCT
admet-625	190	14	whereas	whereas	SCONJ
admet-625	190	15	pharmacological	pharmacological	ADJ
admet-625	190	16	levels	level	NOUN
admet-625	190	17	of	of	ADP
admet-625	190	18	melatonin	melatonin	NOUN
admet-625	190	19	(	(	PUNCT
admet-625	190	20	in	in	ADP
admet-625	190	21	combination	combination	NOUN
admet-625	190	22	with	with	ADP
admet-625	190	23	other	other	ADJ
admet-625	190	24	drugs	drug	NOUN
admet-625	190	25	)	)	PUNCT
admet-625	190	26	contribute	contribute	VERB
admet-625	190	27	to	to	ADP
admet-625	190	28	healing	healing	NOUN
admet-625	190	29	of	of	ADP
admet-625	190	30	gastroduodenal	gastroduodenal	ADJ
admet-625	190	31	ulcers	ulcer	NOUN
admet-625	190	32	.	.	PUNCT
admet-625	191	1	the	the	DET
admet-625	191	2	difference	difference	NOUN
admet-625	191	3	of	of	ADP
admet-625	191	4	goal	goal	NOUN
admet-625	191	5	(	(	PUNCT
admet-625	191	6	i.e.	i.e.	X
admet-625	191	7	gastro	gastro	NOUN
admet-625	191	8	-	-	PUNCT
admet-625	191	9	protection	protection	NOUN
admet-625	191	10	vs	vs	ADP
admet-625	191	11	healing	healing	NOUN
admet-625	191	12	of	of	ADP
admet-625	191	13	local	local	ADJ
admet-625	191	14	ulcer	ulcer	NOUN
admet-625	191	15	)	)	PUNCT
admet-625	191	16	will	will	AUX
admet-625	191	17	be	be	AUX
admet-625	191	18	the	the	DET
admet-625	191	19	discriminating	discriminate	VERB
admet-625	191	20	factor	factor	NOUN
admet-625	191	21	for	for	ADP
admet-625	191	22	selecting	select	VERB
admet-625	191	23	the	the	DET
admet-625	191	24	most	most	ADV
admet-625	191	25	suitable	suitable	ADJ
admet-625	191	26	dose	dose	NOUN
admet-625	191	27	to	to	PART
admet-625	191	28	produce	produce	VERB
admet-625	191	29	either	either	CCONJ
admet-625	191	30	endogenous	endogenous	ADJ
admet-625	191	31	or	or	CCONJ
admet-625	191	32	higher	high	ADJ
admet-625	191	33	levels	level	NOUN
admet-625	191	34	.	.	PUNCT
admet-625	192	1	the	the	DET
admet-625	192	2	velocity	velocity	NOUN
admet-625	192	3	of	of	ADP
admet-625	192	4	excretion	excretion	NOUN
admet-625	192	5	via	via	ADP
admet-625	192	6	the	the	DET
admet-625	192	7	kidneys	kidney	NOUN
admet-625	192	8	is	be	AUX
admet-625	192	9	comparable	comparable	ADJ
admet-625	192	10	for	for	ADP
admet-625	192	11	both	both	CCONJ
admet-625	192	12	the	the	DET
admet-625	192	13	iv	iv	NOUN
admet-625	192	14	and	and	CCONJ
admet-625	192	15	po	po	NOUN
admet-625	192	16	routes	route	NOUN
admet-625	192	17	,	,	PUNCT
admet-625	192	18	and	and	CCONJ
admet-625	192	19	is	be	AUX
admet-625	192	20	faster	fast	ADJ
admet-625	192	21	for	for	ADP
admet-625	192	22	these	these	DET
admet-625	192	23	routes	route	NOUN
admet-625	192	24	when	when	SCONJ
admet-625	192	25	compared	compare	VERB
admet-625	192	26	to	to	ADP
admet-625	192	27	td	td	PROPN
admet-625	192	28	.	.	PUNCT
admet-625	192	29	concluding	conclude	VERB
admet-625	192	30	,	,	PUNCT
admet-625	192	31	anatomical	anatomical	ADJ
admet-625	192	32	and	and	CCONJ
admet-625	192	33	physiological	physiological	ADJ
admet-625	192	34	considerations	consideration	NOUN
admet-625	192	35	can	can	AUX
admet-625	192	36	be	be	AUX
admet-625	192	37	converted	convert	VERB
admet-625	192	38	into	into	ADP
admet-625	192	39	quantitative	quantitative	ADJ
admet-625	192	40	data	datum	NOUN
admet-625	192	41	to	to	PART
admet-625	192	42	be	be	AUX
admet-625	192	43	carefully	carefully	ADV
admet-625	192	44	assessed	assess	VERB
admet-625	192	45	,	,	PUNCT
admet-625	192	46	analyzed	analyze	VERB
admet-625	192	47	,	,	PUNCT
admet-625	192	48	and	and	CCONJ
admet-625	192	49	visualized	visualize	VERB
admet-625	192	50	via	via	ADP
admet-625	192	51	pbpk	pbpk	NOUN
admet-625	192	52	model	model	NOUN
admet-625	192	53	simulations	simulation	NOUN
admet-625	192	54	.	.	PUNCT
admet-625	193	1	this	this	DET
admet-625	193	2	kind	kind	NOUN
admet-625	193	3	of	of	ADP
admet-625	193	4	information	information	NOUN
admet-625	193	5	is	be	AUX
admet-625	193	6	not	not	PART
admet-625	193	7	only	only	ADV
admet-625	193	8	useful	useful	ADJ
admet-625	193	9	when	when	SCONJ
admet-625	193	10	several	several	ADJ
admet-625	193	11	routes	route	NOUN
admet-625	193	12	of	of	ADP
admet-625	193	13	administration	administration	NOUN
admet-625	193	14	are	be	AUX
admet-625	193	15	viable	viable	ADJ
admet-625	193	16	,	,	PUNCT
admet-625	193	17	but	but	CCONJ
admet-625	193	18	also	also	ADV
admet-625	193	19	especially	especially	ADV
admet-625	193	20	important	important	ADJ
admet-625	193	21	when	when	SCONJ
admet-625	193	22	the	the	DET
admet-625	193	23	drug	drug	NOUN
admet-625	193	24	target	target	NOUN
admet-625	193	25	site	site	NOUN
admet-625	193	26	is	be	AUX
admet-625	193	27	not	not	PART
admet-625	193	28	plasma	plasma	NOUN
admet-625	193	29	.	.	PUNCT
admet-625	194	1	admet	admet	PROPN
admet-625	194	2	&	&	CCONJ
admet-625	194	3	dmpk	dmpk	PROPN
admet-625	194	4	7(1	7(1	PROPN
admet-625	194	5	)	)	PUNCT
admet-625	194	6	(	(	PUNCT
admet-625	194	7	2019	2019	NUM
admet-625	194	8	)	)	PUNCT
admet-625	194	9	44	44	NUM
admet-625	194	10	-	-	SYM
admet-625	194	11	59	59	NUM
admet-625	194	12	pbpk	pbpk	ADJ
admet-625	194	13	simulation	simulation	NOUN
admet-625	194	14	in	in	ADP
admet-625	194	15	pharmacotherapy	pharmacotherapy	NOUN
admet-625	194	16	doi	doi	NOUN
admet-625	194	17	:	:	PUNCT
admet-625	194	18	10.5599	10.5599	NUM
admet-625	194	19	/	/	SYM
admet-625	194	20	admet.625	admet.625	NUM
admet-625	194	21	55	55	NUM
admet-625	194	22	figure	figure	NOUN
admet-625	194	23	6	6	NUM
admet-625	194	24	simulation	simulation	NOUN
admet-625	194	25	of	of	ADP
admet-625	194	26	the	the	DET
admet-625	194	27	melatonin	melatonin	NOUN
admet-625	194	28	concentration	concentration	NOUN
admet-625	194	29	dynamics	dynamic	NOUN
admet-625	194	30	in	in	ADP
admet-625	194	31	the	the	DET
admet-625	194	32	compartments	compartment	NOUN
admet-625	194	33	saliva	saliva	NOUN
admet-625	194	34	,	,	PUNCT
admet-625	194	35	liver	liver	NOUN
admet-625	194	36	,	,	PUNCT
admet-625	194	37	highly	highly	ADV
admet-625	194	38	and	and	CCONJ
admet-625	194	39	poorly	poorly	ADV
admet-625	194	40	perfused	perfuse	VERB
admet-625	194	41	organs	organ	NOUN
admet-625	194	42	/	/	SYM
admet-625	194	43	tissues	tissue	NOUN
admet-625	194	44	,	,	PUNCT
admet-625	194	45	and	and	CCONJ
admet-625	194	46	the	the	DET
admet-625	194	47	kidneys	kidney	NOUN
admet-625	194	48	-	-	PUNCT
admet-625	194	49	excreted	excrete	VERB
admet-625	194	50	amount	amount	NOUN
admet-625	194	51	after	after	ADP
admet-625	194	52	administration	administration	NOUN
admet-625	194	53	of	of	ADP
admet-625	194	54	3	3	NUM
admet-625	194	55	mg	mg	NOUN
admet-625	194	56	via	via	ADP
admet-625	194	57	iv	iv	ADP
admet-625	194	58	,	,	PUNCT
admet-625	194	59	po	po	NOUN
admet-625	194	60	,	,	PUNCT
admet-625	194	61	po	po	PROPN
admet-625	194	62	(	(	PUNCT
admet-625	194	63	cr	cr	NOUN
admet-625	194	64	)	)	PUNCT
admet-625	194	65	,	,	PUNCT
admet-625	194	66	and	and	CCONJ
admet-625	194	67	td	td	PROPN
admet-625	194	68	.	.	PUNCT
admet-625	194	69	conclusions	conclusion	NOUN
admet-625	194	70	while	while	SCONJ
admet-625	194	71	pbpk	pbpk	NOUN
admet-625	194	72	simulators	simulator	NOUN
admet-625	194	73	allow	allow	VERB
admet-625	194	74	evaluating	evaluate	VERB
admet-625	194	75	melatonin	melatonin	NOUN
admet-625	194	76	levels	level	NOUN
admet-625	194	77	in	in	ADP
admet-625	194	78	plasma	plasma	NOUN
admet-625	194	79	and	and	CCONJ
admet-625	194	80	the	the	DET
admet-625	194	81	rest	rest	NOUN
admet-625	194	82	of	of	ADP
admet-625	194	83	the	the	DET
admet-625	194	84	body	body	NOUN
admet-625	194	85	,	,	PUNCT
admet-625	194	86	further	far	ADV
admet-625	194	87	practical	practical	ADJ
admet-625	194	88	considerations	consideration	NOUN
admet-625	194	89	should	should	AUX
admet-625	194	90	support	support	VERB
admet-625	194	91	the	the	DET
admet-625	194	92	pharmacokinetic	pharmacokinetic	ADJ
admet-625	194	93	investigation	investigation	NOUN
admet-625	194	94	with	with	ADP
admet-625	194	95	the	the	DET
admet-625	194	96	aim	aim	NOUN
admet-625	194	97	of	of	ADP
admet-625	194	98	achieving	achieve	VERB
admet-625	194	99	optimal	optimal	ADJ
admet-625	194	100	clinical	clinical	ADJ
admet-625	194	101	efficacy	efficacy	NOUN
admet-625	194	102	.	.	PUNCT
admet-625	195	1	in	in	ADP
admet-625	195	2	fact	fact	NOUN
admet-625	195	3	,	,	PUNCT
admet-625	195	4	while	while	SCONJ
admet-625	195	5	iv	iv	NUM
admet-625	195	6	route	route	NOUN
admet-625	195	7	may	may	AUX
admet-625	195	8	hold	hold	VERB
admet-625	195	9	the	the	DET
admet-625	195	10	advantage	advantage	NOUN
admet-625	195	11	of	of	ADP
admet-625	195	12	the	the	DET
admet-625	195	13	highest	high	ADJ
admet-625	195	14	bioavailability	bioavailability	NOUN
admet-625	195	15	and	and	CCONJ
admet-625	195	16	fastest	fast	ADJ
admet-625	195	17	distribution	distribution	NOUN
admet-625	195	18	to	to	ADP
admet-625	195	19	organs	organ	NOUN
admet-625	195	20	and	and	CCONJ
admet-625	195	21	tissues	tissue	NOUN
admet-625	195	22	,	,	PUNCT
admet-625	195	23	most	most	ADJ
admet-625	195	24	of	of	ADP
admet-625	195	25	the	the	DET
admet-625	195	26	patients	patient	NOUN
admet-625	195	27	may	may	AUX
admet-625	195	28	find	find	VERB
admet-625	195	29	it	it	PRON
admet-625	195	30	distressing	distressing	ADJ
admet-625	195	31	.	.	PUNCT
admet-625	196	1	therefore	therefore	ADV
admet-625	196	2	,	,	PUNCT
admet-625	196	3	it	it	PRON
admet-625	196	4	may	may	AUX
admet-625	196	5	result	result	VERB
admet-625	196	6	suitable	suitable	ADJ
admet-625	196	7	only	only	ADV
admet-625	196	8	for	for	ADP
admet-625	196	9	specific	specific	ADJ
admet-625	196	10	categories	category	NOUN
admet-625	196	11	such	such	ADJ
admet-625	196	12	as	as	ADP
admet-625	196	13	critically	critically	ADV
admet-625	196	14	ill	ill	ADJ
admet-625	196	15	patients	patient	NOUN
admet-625	196	16	,	,	PUNCT
admet-625	196	17	who	who	PRON
admet-625	196	18	usually	usually	ADV
admet-625	196	19	receive	receive	VERB
admet-625	196	20	continuous	continuous	ADJ
admet-625	196	21	infusion	infusion	NOUN
admet-625	196	22	of	of	ADP
admet-625	196	23	different	different	ADJ
admet-625	196	24	drugs	drug	NOUN
admet-625	196	25	and	and	CCONJ
admet-625	196	26	enteral	enteral	ADJ
admet-625	196	27	nutrition	nutrition	NOUN
admet-625	196	28	for	for	ADP
admet-625	196	29	quite	quite	ADV
admet-625	196	30	long	long	ADJ
admet-625	196	31	periods	period	NOUN
admet-625	196	32	.	.	PUNCT
admet-625	197	1	on	on	ADP
admet-625	197	2	one	one	NUM
admet-625	197	3	hand	hand	NOUN
admet-625	197	4	,	,	PUNCT
admet-625	197	5	po	po	PROPN
admet-625	197	6	route	route	NOUN
admet-625	197	7	is	be	AUX
admet-625	197	8	easy	easy	ADJ
admet-625	197	9	and	and	CCONJ
admet-625	197	10	simple	simple	ADJ
admet-625	197	11	but	but	CCONJ
admet-625	197	12	it	it	PRON
admet-625	197	13	is	be	AUX
admet-625	197	14	subject	subject	ADJ
admet-625	197	15	to	to	ADP
admet-625	197	16	first	first	ADJ
admet-625	197	17	-	-	PUNCT
admet-625	197	18	pass	pass	VERB
admet-625	197	19	hepatic	hepatic	ADJ
admet-625	197	20	metabolism	metabolism	NOUN
admet-625	197	21	,	,	PUNCT
admet-625	197	22	which	which	PRON
admet-625	197	23	implies	imply	VERB
admet-625	197	24	a	a	DET
admet-625	197	25	certain	certain	ADJ
admet-625	197	26	degree	degree	NOUN
admet-625	197	27	of	of	ADP
admet-625	197	28	inter	inter	ADJ
admet-625	197	29	-	-	ADJ
admet-625	197	30	individual	individual	ADJ
admet-625	197	31	variability	variability	NOUN
admet-625	197	32	related	relate	VERB
admet-625	197	33	to	to	ADP
admet-625	197	34	different	different	ADJ
admet-625	197	35	metabolism	metabolism	NOUN
admet-625	197	36	characteristics	characteristic	NOUN
admet-625	197	37	,	,	PUNCT
admet-625	197	38	and	and	CCONJ
admet-625	197	39	different	different	ADJ
admet-625	197	40	patients	patient	NOUN
admet-625	197	41	’	'	PUNCT
admet-625	197	42	features	feature	NOUN
admet-625	197	43	(	(	PUNCT
admet-625	197	44	e.g.	e.g.	ADV
admet-625	197	45	,	,	PUNCT
admet-625	197	46	savoca	savoca	NOUN
admet-625	197	47	and	and	CCONJ
admet-625	197	48	manca	manca	PROPN
admet-625	197	49	admet	admet	PROPN
admet-625	197	50	&	&	CCONJ
admet-625	197	51	dmpk	dmpk	PROPN
admet-625	197	52	7(1	7(1	PROPN
admet-625	197	53	)	)	PUNCT
admet-625	197	54	(	(	PUNCT
admet-625	197	55	2019	2019	NUM
admet-625	197	56	)	)	PUNCT
admet-625	197	57	44	44	NUM
admet-625	197	58	-	-	SYM
admet-625	197	59	59	59	NUM
admet-625	197	60	56	56	NUM
admet-625	197	61	gastrointestinal	gastrointestinal	ADJ
admet-625	197	62	ph	ph	VERB
admet-625	197	63	,	,	PUNCT
admet-625	197	64	temperature	temperature	NOUN
admet-625	197	65	,	,	PUNCT
admet-625	197	66	and	and	CCONJ
admet-625	197	67	other	other	ADJ
admet-625	197	68	previously	previously	ADV
admet-625	197	69	mentioned	mention	VERB
admet-625	197	70	factors	factor	NOUN
admet-625	197	71	)	)	PUNCT
admet-625	197	72	.	.	PUNCT
admet-625	198	1	as	as	ADV
admet-625	198	2	well	well	ADV
admet-625	198	3	as	as	ADP
admet-625	198	4	po	po	PROPN
admet-625	198	5	(	(	PUNCT
admet-625	198	6	cr	cr	NOUN
admet-625	198	7	)	)	PUNCT
admet-625	198	8	option	option	NOUN
admet-625	198	9	,	,	PUNCT
admet-625	198	10	td	td	ADJ
admet-625	198	11	route	route	NOUN
admet-625	198	12	allows	allow	VERB
admet-625	198	13	obtaining	obtain	VERB
admet-625	198	14	sustained	sustained	ADJ
admet-625	198	15	levels	level	NOUN
admet-625	198	16	and	and	CCONJ
admet-625	198	17	avoids	avoid	VERB
admet-625	198	18	first	first	ADJ
admet-625	198	19	-	-	PUNCT
admet-625	198	20	pass	pass	VERB
admet-625	198	21	hepatic	hepatic	ADJ
admet-625	198	22	metabolism	metabolism	NOUN
admet-625	198	23	.	.	PUNCT
admet-625	199	1	on	on	ADP
admet-625	199	2	the	the	DET
admet-625	199	3	other	other	ADJ
admet-625	199	4	hand	hand	NOUN
admet-625	199	5	,	,	PUNCT
admet-625	199	6	it	it	PRON
admet-625	199	7	is	be	AUX
admet-625	199	8	subject	subject	ADJ
admet-625	199	9	to	to	ADP
admet-625	199	10	slow	slow	ADJ
admet-625	199	11	absorption	absorption	NOUN
admet-625	199	12	through	through	ADP
admet-625	199	13	skin	skin	NOUN
admet-625	199	14	,	,	PUNCT
admet-625	199	15	possible	possible	ADJ
admet-625	199	16	metabolism	metabolism	NOUN
admet-625	199	17	within	within	ADP
admet-625	199	18	viable	viable	ADJ
admet-625	199	19	epidermis	epidermis	NOUN
admet-625	199	20	,	,	PUNCT
admet-625	199	21	and	and	CCONJ
admet-625	199	22	high	high	ADJ
admet-625	199	23	interand	interand	VERB
admet-625	199	24	intra	intra	ADJ
admet-625	199	25	-	-	ADJ
admet-625	199	26	individual	individual	ADJ
admet-625	199	27	variability	variability	NOUN
admet-625	199	28	related	relate	VERB
admet-625	199	29	to	to	ADP
admet-625	199	30	different	different	ADJ
admet-625	199	31	skin	skin	NOUN
admet-625	199	32	features	feature	NOUN
admet-625	199	33	.	.	PUNCT
admet-625	200	1	in	in	ADP
admet-625	200	2	this	this	DET
admet-625	200	3	work	work	NOUN
admet-625	200	4	,	,	PUNCT
admet-625	200	5	we	we	PRON
admet-625	200	6	introduced	introduce	VERB
admet-625	200	7	and	and	CCONJ
admet-625	200	8	discussed	discuss	VERB
admet-625	200	9	a	a	DET
admet-625	200	10	case	case	NOUN
admet-625	200	11	-	-	PUNCT
admet-625	200	12	study	study	NOUN
admet-625	200	13	to	to	PART
admet-625	200	14	compare	compare	VERB
admet-625	200	15	pharmacokinetic	pharmacokinetic	ADJ
admet-625	200	16	levels	level	NOUN
admet-625	200	17	resulting	result	VERB
admet-625	200	18	from	from	ADP
admet-625	200	19	different	different	ADJ
admet-625	200	20	doses	dose	NOUN
admet-625	200	21	and	and	CCONJ
admet-625	200	22	three	three	NUM
admet-625	200	23	administration	administration	NOUN
admet-625	200	24	routes	route	NOUN
admet-625	200	25	,	,	PUNCT
admet-625	200	26	i.e.	i.e.	X
admet-625	200	27	iv	iv	NUM
admet-625	200	28	,	,	PUNCT
admet-625	200	29	po	po	NOUN
admet-625	200	30	,	,	PUNCT
admet-625	200	31	and	and	CCONJ
admet-625	200	32	td	td	NOUN
admet-625	200	33	,	,	PUNCT
admet-625	200	34	also	also	ADV
admet-625	200	35	considering	consider	VERB
admet-625	200	36	both	both	CCONJ
admet-625	200	37	oral	oral	ADJ
admet-625	200	38	immediate	immediate	ADJ
admet-625	200	39	release	release	NOUN
admet-625	200	40	and	and	CCONJ
admet-625	200	41	cr	cr	ADP
admet-625	200	42	formulations	formulation	NOUN
admet-625	200	43	.	.	PUNCT
admet-625	201	1	pbpk	pbpk	NOUN
admet-625	201	2	simulations	simulation	NOUN
admet-625	201	3	are	be	AUX
admet-625	201	4	particularly	particularly	ADV
admet-625	201	5	interesting	interesting	ADJ
admet-625	201	6	for	for	ADP
admet-625	201	7	their	their	PRON
admet-625	201	8	intrinsic	intrinsic	ADJ
admet-625	201	9	nature	nature	NOUN
admet-625	201	10	and	and	CCONJ
admet-625	201	11	structure	structure	NOUN
admet-625	201	12	,	,	PUNCT
admet-625	201	13	because	because	SCONJ
admet-625	201	14	they	they	PRON
admet-625	201	15	provide	provide	VERB
admet-625	201	16	quantitative	quantitative	ADJ
admet-625	201	17	information	information	NOUN
admet-625	201	18	on	on	ADP
admet-625	201	19	the	the	DET
admet-625	201	20	drug	drug	NOUN
admet-625	201	21	adme	adme	NOUN
admet-625	201	22	processes	process	NOUN
admet-625	201	23	in	in	ADP
admet-625	201	24	the	the	DET
admet-625	201	25	body	body	NOUN
admet-625	201	26	.	.	PUNCT
admet-625	202	1	besides	besides	SCONJ
admet-625	202	2	,	,	PUNCT
admet-625	202	3	coupling	couple	VERB
admet-625	202	4	with	with	ADP
admet-625	202	5	intelligent	intelligent	ADJ
admet-625	202	6	drug	drug	NOUN
admet-625	202	7	design	design	NOUN
admet-625	202	8	and	and	CCONJ
admet-625	202	9	in	in	ADP
admet-625	202	10	vitro	vitro	X
admet-625	202	11	experiments	experiment	NOUN
admet-625	202	12	enhances	enhance	VERB
admet-625	202	13	the	the	DET
admet-625	202	14	potential	potential	NOUN
admet-625	202	15	to	to	PART
admet-625	202	16	maximize	maximize	VERB
admet-625	202	17	their	their	PRON
admet-625	202	18	efficacy	efficacy	NOUN
admet-625	202	19	.	.	PUNCT
admet-625	203	1	as	as	ADV
admet-625	203	2	far	far	ADV
admet-625	203	3	as	as	SCONJ
admet-625	203	4	melatonin	melatonin	NOUN
admet-625	203	5	is	be	AUX
admet-625	203	6	concerned	concern	VERB
admet-625	203	7	and	and	CCONJ
admet-625	203	8	with	with	ADP
admet-625	203	9	reference	reference	NOUN
admet-625	203	10	to	to	ADP
admet-625	203	11	both	both	CCONJ
admet-625	203	12	practical	practical	ADJ
admet-625	203	13	and	and	CCONJ
admet-625	203	14	pharmacokinetic	pharmacokinetic	ADJ
admet-625	203	15	aspects	aspect	NOUN
admet-625	203	16	,	,	PUNCT
admet-625	203	17	it	it	PRON
admet-625	203	18	is	be	AUX
admet-625	203	19	possible	possible	ADJ
admet-625	203	20	to	to	PART
admet-625	203	21	conclude	conclude	VERB
admet-625	203	22	that	that	PRON
admet-625	203	23	po	po	PROPN
admet-625	203	24	(	(	PUNCT
admet-625	203	25	cr	cr	NOUN
admet-625	203	26	)	)	PUNCT
admet-625	203	27	and	and	CCONJ
admet-625	203	28	td	td	NOUN
admet-625	203	29	routes	route	NOUN
admet-625	203	30	represent	represent	VERB
admet-625	203	31	the	the	DET
admet-625	203	32	best	good	ADJ
admet-625	203	33	options	option	NOUN
admet-625	203	34	in	in	ADP
admet-625	203	35	case	case	NOUN
admet-625	203	36	of	of	ADP
admet-625	203	37	disruption	disruption	NOUN
admet-625	203	38	of	of	ADP
admet-625	203	39	the	the	DET
admet-625	203	40	endogenous	endogenous	ADJ
admet-625	203	41	rhythm	rhythm	NOUN
admet-625	203	42	(	(	PUNCT
admet-625	203	43	e.g.	e.g.	ADV
admet-625	203	44	,	,	PUNCT
admet-625	203	45	in	in	ADP
admet-625	203	46	people	people	NOUN
admet-625	203	47	suffering	suffer	VERB
admet-625	203	48	from	from	ADP
admet-625	203	49	either	either	PRON
admet-625	203	50	insomnia	insomnia	NOUN
admet-625	203	51	or	or	CCONJ
admet-625	203	52	jet	jet	NOUN
admet-625	203	53	-	-	PUNCT
admet-625	203	54	lag	lag	NOUN
admet-625	203	55	and	and	CCONJ
admet-625	203	56	critically	critically	ADV
admet-625	203	57	ills	ill	NOUN
admet-625	203	58	)	)	PUNCT
admet-625	203	59	.	.	PUNCT
admet-625	204	1	equally	equally	ADV
admet-625	204	2	,	,	PUNCT
admet-625	204	3	po	po	INTJ
admet-625	204	4	(	(	PUNCT
admet-625	204	5	with	with	ADP
admet-625	204	6	doses	dose	NOUN
admet-625	204	7	significantly	significantly	ADV
admet-625	204	8	higher	high	ADJ
admet-625	204	9	than	than	ADP
admet-625	204	10	3	3	NUM
admet-625	204	11	mg	mg	NOUN
admet-625	204	12	)	)	PUNCT
admet-625	204	13	and	and	CCONJ
admet-625	204	14	iv	iv	NUM
admet-625	204	15	infusion	infusion	NOUN
admet-625	204	16	are	be	AUX
admet-625	204	17	preferable	preferable	ADJ
admet-625	204	18	when	when	SCONJ
admet-625	204	19	higher	high	ADJ
admet-625	204	20	concentration	concentration	NOUN
admet-625	204	21	levels	level	NOUN
admet-625	204	22	are	be	AUX
admet-625	204	23	required	require	VERB
admet-625	204	24	for	for	ADP
admet-625	204	25	other	other	ADJ
admet-625	204	26	goals	goal	NOUN
admet-625	204	27	,	,	PUNCT
admet-625	204	28	for	for	ADP
admet-625	204	29	instance	instance	NOUN
admet-625	204	30	to	to	PART
admet-625	204	31	contrast	contrast	VERB
admet-625	204	32	severe	severe	ADJ
admet-625	204	33	oxidative	oxidative	ADJ
admet-625	204	34	stress	stress	NOUN
admet-625	204	35	and	and	CCONJ
admet-625	204	36	possibly	possibly	ADV
admet-625	204	37	cancer	cancer	NOUN
admet-625	204	38	,	,	PUNCT
admet-625	204	39	and	and	CCONJ
admet-625	204	40	target	target	VERB
admet-625	204	41	specific	specific	ADJ
admet-625	204	42	organs	organ	NOUN
admet-625	204	43	as	as	ADP
admet-625	204	44	sites	site	NOUN
admet-625	204	45	of	of	ADP
admet-625	204	46	pharmacological	pharmacological	ADJ
admet-625	204	47	action	action	NOUN
admet-625	204	48	.	.	PUNCT
admet-625	205	1	this	this	DET
admet-625	205	2	work	work	NOUN
admet-625	205	3	can	can	AUX
admet-625	205	4	be	be	AUX
admet-625	205	5	extended	extend	VERB
admet-625	205	6	and	and	CCONJ
admet-625	205	7	improved	improve	VERB
admet-625	205	8	by	by	ADP
admet-625	205	9	focusing	focus	VERB
admet-625	205	10	on	on	ADP
admet-625	205	11	one	one	NUM
admet-625	205	12	administration	administration	NOUN
admet-625	205	13	route	route	NOUN
admet-625	205	14	and	and	CCONJ
admet-625	205	15	running	run	VERB
admet-625	205	16	a	a	DET
admet-625	205	17	numerical	numerical	ADJ
admet-625	205	18	optimization	optimization	NOUN
admet-625	205	19	of	of	ADP
admet-625	205	20	the	the	DET
admet-625	205	21	melatonin	melatonin	NOUN
admet-625	205	22	dose	dose	VERB
admet-625	205	23	respect	respect	NOUN
admet-625	205	24	to	to	ADP
admet-625	205	25	a	a	DET
admet-625	205	26	target	target	NOUN
admet-625	205	27	trajectory	trajectory	NOUN
admet-625	205	28	,	,	PUNCT
admet-625	205	29	also	also	ADV
admet-625	205	30	considering	consider	VERB
admet-625	205	31	a	a	DET
admet-625	205	32	number	number	NOUN
admet-625	205	33	of	of	ADP
admet-625	205	34	degrees	degree	NOUN
admet-625	205	35	of	of	ADP
admet-625	205	36	freedom	freedom	NOUN
admet-625	205	37	depending	depend	VERB
admet-625	205	38	on	on	ADP
admet-625	205	39	the	the	DET
admet-625	205	40	selected	select	VERB
admet-625	205	41	route	route	NOUN
admet-625	205	42	.	.	PUNCT
admet-625	206	1	it	it	PRON
admet-625	206	2	is	be	AUX
admet-625	206	3	also	also	ADV
admet-625	206	4	worth	worth	ADJ
admet-625	206	5	stressing	stress	VERB
admet-625	206	6	the	the	DET
admet-625	206	7	transferability	transferability	NOUN
admet-625	206	8	of	of	ADP
admet-625	206	9	the	the	DET
admet-625	206	10	presented	present	VERB
admet-625	206	11	approach	approach	NOUN
admet-625	206	12	to	to	ADP
admet-625	206	13	any	any	DET
admet-625	206	14	other	other	ADJ
admet-625	206	15	drugs	drug	NOUN
admet-625	206	16	that	that	PRON
admet-625	206	17	are	be	AUX
admet-625	206	18	versatile	versatile	ADJ
admet-625	206	19	from	from	ADP
admet-625	206	20	the	the	DET
admet-625	206	21	point	point	NOUN
admet-625	206	22	of	of	ADP
admet-625	206	23	view	view	NOUN
admet-625	206	24	of	of	ADP
admet-625	206	25	the	the	DET
admet-625	206	26	administration	administration	NOUN
admet-625	206	27	routes	route	NOUN
admet-625	206	28	.	.	PUNCT
admet-625	207	1	such	such	ADJ
admet-625	207	2	investigations	investigation	NOUN
admet-625	207	3	may	may	AUX
admet-625	207	4	become	become	VERB
admet-625	207	5	especially	especially	ADV
admet-625	207	6	interesting	interesting	ADJ
admet-625	207	7	in	in	ADP
admet-625	207	8	case	case	NOUN
admet-625	207	9	of	of	ADP
admet-625	207	10	drugs	drug	NOUN
admet-625	207	11	with	with	ADP
admet-625	207	12	narrow	narrow	ADJ
admet-625	207	13	therapeutic	therapeutic	ADJ
admet-625	207	14	windows	window	NOUN
admet-625	207	15	,	,	PUNCT
admet-625	207	16	such	such	ADJ
admet-625	207	17	as	as	ADP
admet-625	207	18	chemotherapy	chemotherapy	NOUN
admet-625	207	19	drugs	drug	NOUN
admet-625	207	20	whose	whose	DET
admet-625	207	21	pharmacokinetics	pharmacokinetic	NOUN
admet-625	207	22	quantification	quantification	NOUN
admet-625	207	23	is	be	AUX
admet-625	207	24	essential	essential	ADJ
admet-625	207	25	and	and	CCONJ
admet-625	207	26	critical	critical	ADJ
admet-625	207	27	.	.	PUNCT
admet-625	208	1	acknowledgements	acknowledgement	NOUN
admet-625	208	2	:	:	PUNCT
admet-625	208	3	the	the	DET
admet-625	208	4	authors	author	NOUN
admet-625	208	5	acknowledge	acknowledge	VERB
admet-625	208	6	the	the	DET
admet-625	208	7	precious	precious	ADJ
admet-625	208	8	discussions	discussion	NOUN
admet-625	208	9	and	and	CCONJ
admet-625	208	10	suggestions	suggestion	NOUN
admet-625	208	11	provided	provide	VERB
admet-625	208	12	by	by	ADP
admet-625	208	13	dr	dr	PROPN
admet-625	208	14	.	.	PROPN
admet-625	208	15	giovanni	giovanni	PROPN
admet-625	208	16	mistraletti	mistraletti	PROPN
admet-625	208	17	and	and	CCONJ
admet-625	208	18	prof	prof	PROPN
admet-625	208	19	.	.	PUNCT
admet-625	209	1	franco	franco	PROPN
admet-625	209	2	fraschini	fraschini	PROPN
admet-625	209	3	.	.	PUNCT
admet-625	210	1	conflict	conflict	NOUN
admet-625	210	2	of	of	ADP
admet-625	210	3	interest	interest	NOUN
admet-625	210	4	:	:	PUNCT
admet-625	210	5	none	none	NOUN
admet-625	210	6	.	.	PUNCT
admet-625	211	1	references	reference	NOUN
admet-625	211	2	[	[	X
admet-625	211	3	1	1	NUM
admet-625	211	4	]	]	X
admet-625	211	5	h.m	h.m	PROPN
admet-625	211	6	.	.	PROPN
admet-625	211	7	jones	jones	PROPN
admet-625	211	8	,	,	PUNCT
admet-625	211	9	i.b	i.b	PROPN
admet-625	211	10	.	.	PROPN
admet-625	211	11	gardner	gardner	PROPN
admet-625	211	12	,	,	PUNCT
admet-625	211	13	w.t	w.t	PROPN
admet-625	211	14	.	.	PROPN
admet-625	211	15	collard	collard	PROPN
admet-625	211	16	,	,	PUNCT
admet-625	211	17	p.j	p.j	PROPN
admet-625	211	18	.	.	PROPN
admet-625	211	19	stanley	stanley	PROPN
admet-625	211	20	,	,	PUNCT
admet-625	211	21	p.	p.	PROPN
admet-625	211	22	oxley	oxley	PROPN
admet-625	211	23	,	,	PUNCT
admet-625	211	24	n.a	n.a	PROPN
admet-625	211	25	.	.	PROPN
admet-625	211	26	hosea	hosea	PROPN
admet-625	211	27	,	,	PUNCT
admet-625	211	28	d.	d.	PROPN
admet-625	211	29	plowchalk	plowchalk	PROPN
admet-625	211	30	,	,	PUNCT
admet-625	211	31	s.	s.	PROPN
admet-625	211	32	gernhardt	gernhardt	PROPN
admet-625	211	33	,	,	PUNCT
admet-625	211	34	j.	j.	PROPN
admet-625	211	35	lin	lin	PROPN
admet-625	211	36	,	,	PUNCT
admet-625	211	37	m.	m.	NOUN
admet-625	211	38	dickins	dickin	NOUN
admet-625	211	39	,	,	PUNCT
admet-625	211	40	s.r	s.r	PROPN
admet-625	211	41	.	.	PROPN
admet-625	211	42	rahavendran	rahavendran	PROPN
admet-625	211	43	,	,	PUNCT
admet-625	211	44	b.c	b.c	PROPN
admet-625	211	45	.	.	PROPN
admet-625	211	46	jones	jones	PROPN
admet-625	211	47	,	,	PUNCT
admet-625	211	48	k.j	k.j	PROPN
admet-625	211	49	.	.	PROPN
admet-625	211	50	watson	watson	PROPN
admet-625	211	51	,	,	PUNCT
admet-625	211	52	h.	h.	PROPN
admet-625	211	53	pertinez	pertinez	PROPN
admet-625	211	54	,	,	PUNCT
admet-625	211	55	v.	v.	PROPN
admet-625	211	56	kumar	kumar	PROPN
admet-625	211	57	,	,	PUNCT
admet-625	211	58	s.	s.	PROPN
admet-625	211	59	cole	cole	PROPN
admet-625	211	60	.	.	PUNCT
admet-625	212	1	simulation	simulation	NOUN
admet-625	212	2	of	of	ADP
admet-625	212	3	human	human	PROPN
admet-625	212	4	intravenous	intravenous	ADJ
admet-625	212	5	and	and	CCONJ
admet-625	212	6	oral	oral	ADJ
admet-625	212	7	pharmacokinetics	pharmacokinetic	NOUN
admet-625	212	8	of	of	ADP
admet-625	212	9	21	21	NUM
admet-625	212	10	diverse	diverse	ADJ
admet-625	212	11	compounds	compound	NOUN
admet-625	212	12	using	use	VERB
admet-625	212	13	physiologically	physiologically	ADV
admet-625	212	14	based	base	VERB
admet-625	212	15	pharmacokinetic	pharmacokinetic	ADJ
admet-625	212	16	modelling	modelling	NOUN
admet-625	212	17	.	.	PUNCT
admet-625	213	1	clin	clin	PROPN
admet-625	213	2	.	.	PUNCT
admet-625	213	3	pharmacokinet	pharmacokinet	PROPN
admet-625	213	4	.	.	PUNCT
admet-625	214	1	50	50	NUM
admet-625	214	2	(	(	PUNCT
admet-625	214	3	2011	2011	NUM
admet-625	214	4	)	)	PUNCT
admet-625	214	5	331	331	NUM
admet-625	214	6	-	-	SYM
admet-625	214	7	347	347	NUM
admet-625	214	8	.	.	PUNCT
admet-625	215	1	[	[	X
admet-625	215	2	2	2	NUM
admet-625	215	3	]	]	PUNCT
admet-625	215	4	a.	a.	NOUN
admet-625	215	5	savoca	savoca	PROPN
admet-625	215	6	,	,	PUNCT
admet-625	215	7	g.	g.	PROPN
admet-625	215	8	mistraletti	mistraletti	PROPN
admet-625	215	9	,	,	PUNCT
admet-625	215	10	d.	d.	PROPN
admet-625	215	11	manca	manca	PROPN
admet-625	215	12	.	.	PUNCT
admet-625	216	1	a	a	DET
admet-625	216	2	physiologically	physiologically	ADV
admet-625	216	3	-	-	PUNCT
admet-625	216	4	based	base	VERB
admet-625	216	5	diffusion	diffusion	NOUN
admet-625	216	6	-	-	PUNCT
admet-625	216	7	compartment	compartment	NOUN
admet-625	216	8	model	model	NOUN
admet-625	216	9	for	for	ADP
admet-625	216	10	transdermal	transdermal	ADJ
admet-625	216	11	administration	administration	NOUN
admet-625	216	12	–	–	PUNCT
admet-625	216	13	the	the	DET
admet-625	216	14	melatonin	melatonin	NOUN
admet-625	216	15	case	case	NOUN
admet-625	216	16	study	study	NOUN
admet-625	216	17	.	.	PUNCT
admet-625	217	1	comput	comput	NOUN
admet-625	217	2	.	.	PUNCT
admet-625	218	1	chem	chem	NOUN
admet-625	218	2	.	.	PUNCT
admet-625	219	1	eng	eng	PROPN
admet-625	219	2	.	.	PROPN
admet-625	219	3	113	113	NUM
admet-625	219	4	(	(	PUNCT
admet-625	219	5	2018	2018	NUM
admet-625	219	6	)	)	PUNCT
admet-625	219	7	115	115	NUM
admet-625	219	8	-	-	SYM
admet-625	219	9	124	124	NUM
admet-625	219	10	.	.	PUNCT
admet-625	220	1	[	[	X
admet-625	220	2	3	3	X
admet-625	220	3	]	]	X
admet-625	220	4	c.	c.	PROPN
admet-625	220	5	hall	hall	PROPN
admet-625	220	6	,	,	PUNCT
admet-625	220	7	e.	e.	PROPN
admet-625	220	8	lueshen	lueshen	PROPN
admet-625	220	9	,	,	PUNCT
admet-625	220	10	a.	a.	NOUN
admet-625	220	11	mošat	mošat	NOUN
admet-625	220	12	'	'	PROPN
admet-625	220	13	,	,	PUNCT
admet-625	220	14	a.a	a.a	PROPN
admet-625	220	15	.	.	PROPN
admet-625	220	16	linninger	linninger	PROPN
admet-625	220	17	.	.	PUNCT
admet-625	221	1	interspecies	interspecie	NOUN
admet-625	221	2	scaling	scale	VERB
admet-625	221	3	in	in	ADP
admet-625	221	4	pharmacokinetics	pharmacokinetic	NOUN
admet-625	221	5	:	:	PUNCT
admet-625	221	6	a	a	DET
admet-625	221	7	novel	novel	ADJ
admet-625	221	8	whole	whole	ADJ
admet-625	221	9	-	-	PUNCT
admet-625	221	10	body	body	NOUN
admet-625	221	11	physiologically	physiologically	ADV
admet-625	221	12	based	base	VERB
admet-625	221	13	modeling	modeling	NOUN
admet-625	221	14	framework	framework	NOUN
admet-625	221	15	to	to	PART
admet-625	221	16	discover	discover	VERB
admet-625	221	17	drug	drug	NOUN
admet-625	221	18	biodistribution	biodistribution	NOUN
admet-625	221	19	mechanisms	mechanism	NOUN
admet-625	221	20	in	in	ADP
admet-625	221	21	vivo	vivo	NOUN
admet-625	221	22	.	.	PUNCT
admet-625	222	1	j.	j.	PROPN
admet-625	222	2	pharm	pharm	PROPN
admet-625	222	3	.	.	PUNCT
admet-625	223	1	sci	sci	PROPN
admet-625	223	2	.	.	PROPN
admet-625	224	1	101	101	NUM
admet-625	224	2	(	(	PUNCT
admet-625	224	3	2012	2012	NUM
admet-625	224	4	)	)	PUNCT
admet-625	224	5	1221	1221	NUM
admet-625	224	6	-	-	SYM
admet-625	224	7	1241	1241	NUM
admet-625	224	8	.	.	PUNCT
admet-625	225	1	[	[	X
admet-625	225	2	4	4	NUM
admet-625	225	3	]	]	X
admet-625	225	4	f.y	f.y	PROPN
admet-625	225	5	.	.	PROPN
admet-625	225	6	bois	bois	PROPN
admet-625	225	7	,	,	PUNCT
admet-625	225	8	m.	m.	PROPN
admet-625	225	9	jamei	jamei	PROPN
admet-625	225	10	,	,	PUNCT
admet-625	225	11	h.j	h.j	PROPN
admet-625	225	12	.	.	PROPN
admet-625	225	13	clewell	clewell	PROPN
admet-625	225	14	.	.	PUNCT
admet-625	226	1	pbpk	pbpk	NOUN
admet-625	226	2	modelling	modelling	NOUN
admet-625	226	3	of	of	ADP
admet-625	226	4	inter	inter	ADJ
admet-625	226	5	-	-	ADJ
admet-625	226	6	individual	individual	ADJ
admet-625	226	7	variability	variability	NOUN
admet-625	226	8	in	in	ADP
admet-625	226	9	the	the	DET
admet-625	226	10	pharmacokinetics	pharmacokinetic	NOUN
admet-625	226	11	of	of	ADP
admet-625	226	12	environmental	environmental	ADJ
admet-625	226	13	chemicals	chemical	NOUN
admet-625	226	14	.	.	PUNCT
admet-625	227	1	toxicology	toxicology	NOUN
admet-625	227	2	278	278	NUM
admet-625	227	3	(	(	PUNCT
admet-625	227	4	2010	2010	NUM
admet-625	227	5	)	)	PUNCT
admet-625	227	6	256	256	NUM
admet-625	227	7	-	-	SYM
admet-625	227	8	267	267	NUM
admet-625	227	9	.	.	PUNCT
admet-625	228	1	[	[	X
admet-625	228	2	5	5	NUM
admet-625	228	3	]	]	PUNCT
admet-625	228	4	z.	z.	PROPN
admet-625	228	5	lin	lin	PROPN
admet-625	228	6	,	,	PUNCT
admet-625	228	7	n.a	n.a	PROPN
admet-625	228	8	.	.	PROPN
admet-625	228	9	monteiro	monteiro	PROPN
admet-625	228	10	-	-	PUNCT
admet-625	228	11	riviere	riviere	PROPN
admet-625	228	12	,	,	PUNCT
admet-625	228	13	r.	r.	PROPN
admet-625	228	14	kannan	kannan	PROPN
admet-625	228	15	,	,	PUNCT
admet-625	228	16	j.e	j.e	PROPN
admet-625	228	17	.	.	PROPN
admet-625	228	18	riviere	riviere	PROPN
admet-625	228	19	.	.	PUNCT
admet-625	229	1	a	a	DET
admet-625	229	2	computational	computational	ADJ
admet-625	229	3	framework	framework	NOUN
admet-625	229	4	for	for	ADP
admet-625	229	5	interspecies	interspecie	NOUN
admet-625	229	6	pharmacokinetics	pharmacokinetic	NOUN
admet-625	229	7	,	,	PUNCT
admet-625	229	8	exposure	exposure	NOUN
admet-625	229	9	and	and	CCONJ
admet-625	229	10	toxicity	toxicity	NOUN
admet-625	229	11	assessment	assessment	NOUN
admet-625	229	12	of	of	ADP
admet-625	229	13	gold	gold	ADJ
admet-625	229	14	nanoparticles	nanoparticle	NOUN
admet-625	229	15	.	.	PUNCT
admet-625	230	1	nanomedicine	nanomedicine	ADJ
admet-625	230	2	11	11	NUM
admet-625	230	3	(	(	PUNCT
admet-625	230	4	2016	2016	NUM
admet-625	230	5	)	)	PUNCT
admet-625	230	6	107	107	NUM
admet-625	230	7	-	-	SYM
admet-625	230	8	119	119	NUM
admet-625	230	9	.	.	PUNCT
admet-625	231	1	[	[	X
admet-625	231	2	6	6	NUM
admet-625	231	3	]	]	PUNCT
admet-625	231	4	a.	a.	NOUN
admet-625	231	5	ke	ke	PROPN
admet-625	231	6	,	,	PUNCT
admet-625	231	7	s.	s.	PROPN
admet-625	231	8	nallani	nallani	PROPN
admet-625	231	9	,	,	PUNCT
admet-625	231	10	p.	p.	PROPN
admet-625	231	11	zhao	zhao	PROPN
admet-625	231	12	,	,	PUNCT
admet-625	231	13	a.	a.	PROPN
admet-625	231	14	rostami	rostami	PROPN
admet-625	231	15	-	-	PUNCT
admet-625	231	16	hodjegan	hodjegan	PROPN
admet-625	231	17	,	,	PUNCT
admet-625	231	18	j.	j.	PROPN
admet-625	231	19	unadkat	unadkat	PROPN
admet-625	231	20	.	.	PUNCT
admet-625	232	1	a	a	DET
admet-625	232	2	pbpk	pbpk	ADJ
admet-625	232	3	model	model	NOUN
admet-625	232	4	to	to	PART
admet-625	232	5	predict	predict	VERB
admet-625	232	6	disposition	disposition	NOUN
admet-625	232	7	of	of	ADP
admet-625	232	8	cyp3a	cyp3a	NOUN
admet-625	232	9	-	-	PUNCT
admet-625	232	10	metabolized	metabolize	VERB
admet-625	232	11	drugs	drug	NOUN
admet-625	232	12	in	in	ADP
admet-625	232	13	pregnant	pregnant	ADJ
admet-625	232	14	women	woman	NOUN
admet-625	232	15	:	:	PUNCT
admet-625	232	16	verification	verification	NOUN
admet-625	232	17	and	and	CCONJ
admet-625	232	18	discerning	discern	VERB
admet-625	232	19	the	the	DET
admet-625	232	20	site	site	NOUN
admet-625	232	21	of	of	ADP
admet-625	232	22	cyp3a	cyp3a	NOUN
admet-625	232	23	induction	induction	NOUN
admet-625	232	24	.	.	PUNCT
admet-625	233	1	cpt	cpt	NOUN
admet-625	233	2	:	:	PUNCT
admet-625	233	3	pharmacometrics	pharmacometrics	PROPN
admet-625	233	4	&	&	CCONJ
admet-625	233	5	systems	systems	PROPN
admet-625	233	6	pharmacology	pharmacology	NOUN
admet-625	233	7	1	1	NUM
admet-625	233	8	(	(	PUNCT
admet-625	233	9	2012	2012	NUM
admet-625	233	10	)	)	PUNCT
admet-625	233	11	3	3	NUM
admet-625	233	12	.	.	X
admet-625	233	13	admet	admet	PROPN
admet-625	233	14	&	&	CCONJ
admet-625	233	15	dmpk	dmpk	PROPN
admet-625	233	16	7(1	7(1	PROPN
admet-625	233	17	)	)	PUNCT
admet-625	233	18	(	(	PUNCT
admet-625	233	19	2019	2019	NUM
admet-625	233	20	)	)	PUNCT
admet-625	233	21	44	44	NUM
admet-625	233	22	-	-	SYM
admet-625	233	23	59	59	NUM
admet-625	233	24	pbpk	pbpk	ADJ
admet-625	233	25	simulation	simulation	NOUN
admet-625	233	26	in	in	ADP
admet-625	233	27	pharmacotherapy	pharmacotherapy	NOUN
admet-625	233	28	doi	doi	NOUN
admet-625	233	29	:	:	PUNCT
admet-625	233	30	10.5599	10.5599	NUM
admet-625	233	31	/	/	SYM
admet-625	233	32	admet.625	admet.625	NUM
admet-625	233	33	57	57	NUM
admet-625	234	1	[	[	X
admet-625	234	2	7	7	NUM
admet-625	234	3	]	]	PUNCT
admet-625	234	4	k.	k.	PROPN
admet-625	234	5	abduljalil	abduljalil	PROPN
admet-625	234	6	,	,	PUNCT
admet-625	234	7	m.	m.	NOUN
admet-625	234	8	jamei	jamei	PROPN
admet-625	234	9	,	,	PUNCT
admet-625	234	10	a.	a.	PROPN
admet-625	234	11	rostami	rostami	PROPN
admet-625	234	12	-	-	PUNCT
admet-625	234	13	hodjegan	hodjegan	NOUN
admet-625	234	14	,	,	PUNCT
admet-625	234	15	t.n	t.n	PROPN
admet-625	234	16	.	.	PROPN
admet-625	234	17	johnson	johnson	PROPN
admet-625	234	18	.	.	PUNCT
admet-625	235	1	changes	change	NOUN
admet-625	235	2	in	in	ADP
admet-625	235	3	individual	individual	ADJ
admet-625	235	4	drug	drug	NOUN
admet-625	235	5	-	-	PUNCT
admet-625	235	6	independent	independent	ADJ
admet-625	235	7	system	system	NOUN
admet-625	235	8	parameters	parameter	NOUN
admet-625	235	9	during	during	ADP
admet-625	235	10	virtual	virtual	ADJ
admet-625	235	11	paediatric	paediatric	ADJ
admet-625	235	12	pharmacokinetic	pharmacokinetic	ADJ
admet-625	235	13	trials	trial	NOUN
admet-625	235	14	:	:	PUNCT
admet-625	235	15	introducing	introduce	VERB
admet-625	235	16	time	time	NOUN
admet-625	235	17	-	-	PUNCT
admet-625	235	18	varying	vary	VERB
admet-625	235	19	physiology	physiology	NOUN
admet-625	235	20	into	into	ADP
admet-625	235	21	a	a	DET
admet-625	235	22	paediatric	paediatric	ADJ
admet-625	235	23	pbpk	pbpk	NOUN
admet-625	235	24	model	model	NOUN
admet-625	235	25	.	.	PUNCT
admet-625	236	1	the	the	DET
admet-625	236	2	aaps	aaps	PROPN
admet-625	236	3	journal	journal	PROPN
admet-625	236	4	16	16	NUM
admet-625	236	5	(	(	PUNCT
admet-625	236	6	2014	2014	NUM
admet-625	236	7	)	)	PUNCT
admet-625	236	8	568	568	NUM
admet-625	236	9	-	-	SYM
admet-625	236	10	576	576	NUM
admet-625	236	11	.	.	PUNCT
admet-625	237	1	[	[	X
admet-625	237	2	8	8	X
admet-625	237	3	]	]	X
admet-625	237	4	t.	t.	NOUN
admet-625	237	5	teorell	teorell	PROPN
admet-625	237	6	.	.	PUNCT
admet-625	238	1	kinetics	kinetic	NOUN
admet-625	238	2	of	of	ADP
admet-625	238	3	distribution	distribution	NOUN
admet-625	238	4	of	of	ADP
admet-625	238	5	substances	substance	NOUN
admet-625	238	6	administered	administer	VERB
admet-625	238	7	to	to	ADP
admet-625	238	8	the	the	DET
admet-625	238	9	body	body	NOUN
admet-625	238	10	,	,	PUNCT
admet-625	238	11	i	i	PRON
admet-625	238	12	:	:	PUNCT
admet-625	238	13	the	the	DET
admet-625	238	14	extravascular	extravascular	ADJ
admet-625	238	15	modes	mode	NOUN
admet-625	238	16	of	of	ADP
admet-625	238	17	administration	administration	NOUN
admet-625	238	18	.	.	PUNCT
admet-625	239	1	archives	archive	NOUN
admet-625	239	2	internationales	internationale	NOUN
admet-625	239	3	de	de	X
admet-625	239	4	pharmacodynamie	pharmacodynamie	PROPN
admet-625	239	5	et	et	PROPN
admet-625	239	6	de	de	PROPN
admet-625	239	7	therapie	therapie	PROPN
admet-625	239	8	57	57	NUM
admet-625	239	9	(	(	PUNCT
admet-625	239	10	1937	1937	NUM
admet-625	239	11	)	)	PUNCT
admet-625	239	12	205	205	NUM
admet-625	239	13	-	-	SYM
admet-625	239	14	225	225	NUM
admet-625	239	15	.	.	PUNCT
admet-625	240	1	[	[	X
admet-625	240	2	9	9	NUM
admet-625	240	3	]	]	X
admet-625	240	4	j.e	j.e	PROPN
admet-625	240	5	.	.	PROPN
admet-625	240	6	sager	sager	PROPN
admet-625	240	7	,	,	PUNCT
admet-625	240	8	j.	j.	PROPN
admet-625	240	9	yu	yu	PROPN
admet-625	240	10	,	,	PUNCT
admet-625	240	11	i.	i.	PROPN
admet-625	240	12	raguenau	raguenau	PROPN
admet-625	240	13	-	-	PUNCT
admet-625	240	14	majlessi	majlessi	NOUN
admet-625	240	15	,	,	PUNCT
admet-625	240	16	n.	n.	PROPN
admet-625	240	17	isoherranen	isoherranen	PROPN
admet-625	240	18	.	.	PUNCT
admet-625	241	1	physiologically	physiologically	ADV
admet-625	241	2	based	base	VERB
admet-625	241	3	pharmacokinetic	pharmacokinetic	ADJ
admet-625	241	4	(	(	PUNCT
admet-625	241	5	pbpk	pbpk	NOUN
admet-625	241	6	)	)	PUNCT
admet-625	241	7	modeling	modeling	NOUN
admet-625	241	8	and	and	CCONJ
admet-625	241	9	simulation	simulation	NOUN
admet-625	241	10	approaches	approach	NOUN
admet-625	241	11	:	:	PUNCT
admet-625	241	12	a	a	DET
admet-625	241	13	systematic	systematic	ADJ
admet-625	241	14	review	review	NOUN
admet-625	241	15	of	of	ADP
admet-625	241	16	published	publish	VERB
admet-625	241	17	models	model	NOUN
admet-625	241	18	,	,	PUNCT
admet-625	241	19	applications	application	NOUN
admet-625	241	20	and	and	CCONJ
admet-625	241	21	model	model	NOUN
admet-625	241	22	verification	verification	NOUN
admet-625	241	23	.	.	PUNCT
admet-625	242	1	drug	drug	NOUN
admet-625	242	2	metab	metab	NOUN
admet-625	242	3	.	.	PUNCT
admet-625	243	1	dispos	dispos	PROPN
admet-625	243	2	.	.	PUNCT
admet-625	244	1	43	43	NUM
admet-625	244	2	(	(	PUNCT
admet-625	244	3	2015	2015	NUM
admet-625	244	4	)	)	PUNCT
admet-625	244	5	1823	1823	NUM
admet-625	244	6	-	-	SYM
admet-625	244	7	1837	1837	NUM
admet-625	244	8	.	.	PUNCT
admet-625	245	1	[	[	X
admet-625	245	2	10	10	NUM
admet-625	245	3	]	]	X
admet-625	245	4	r.a	r.a	PROPN
admet-625	245	5	.	.	PROPN
admet-625	245	6	abbiati	abbiati	PROPN
admet-625	245	7	,	,	PUNCT
admet-625	245	8	a.	a.	NOUN
admet-625	245	9	savoca	savoca	PROPN
admet-625	245	10	,	,	PUNCT
admet-625	245	11	d.	d.	PROPN
admet-625	245	12	manca	manca	PROPN
admet-625	245	13	,	,	PUNCT
admet-625	245	14	chapter	chapter	NOUN
admet-625	245	15	2	2	NUM
admet-625	245	16	an	an	DET
admet-625	245	17	engineering	engineering	NOUN
admet-625	245	18	oriented	orient	VERB
admet-625	245	19	approach	approach	NOUN
admet-625	245	20	to	to	ADP
admet-625	245	21	physiologically	physiologically	ADV
admet-625	245	22	based	base	VERB
admet-625	245	23	pharmacokinetic	pharmacokinetic	ADJ
admet-625	245	24	and	and	CCONJ
admet-625	245	25	pharmacodynamic	pharmacodynamic	ADJ
admet-625	245	26	modeling	modeling	NOUN
admet-625	245	27	,	,	PUNCT
admet-625	245	28	in	in	ADP
admet-625	245	29	:	:	PUNCT
admet-625	245	30	d.	d.	PROPN
admet-625	245	31	manca	manca	PROPN
admet-625	245	32	(	(	PUNCT
admet-625	245	33	ed	ed	NOUN
admet-625	245	34	.	.	PUNCT
admet-625	245	35	)	)	PUNCT
admet-625	246	1	computer	computer	NOUN
admet-625	246	2	aided	aid	VERB
admet-625	246	3	chemical	chemical	NOUN
admet-625	246	4	engineering	engineering	NOUN
admet-625	246	5	,	,	PUNCT
admet-625	246	6	elsevier	elsevier	NOUN
admet-625	246	7	(	(	PUNCT
admet-625	246	8	2018	2018	NUM
admet-625	246	9	)	)	PUNCT
admet-625	246	10	,	,	PUNCT
admet-625	246	11	pp	pp	ADJ
admet-625	246	12	.	.	PUNCT
admet-625	247	1	37	37	NUM
admet-625	247	2	-	-	SYM
admet-625	247	3	63	63	NUM
admet-625	247	4	.	.	PUNCT
admet-625	248	1	[	[	X
admet-625	248	2	11	11	NUM
admet-625	248	3	]	]	PUNCT
admet-625	248	4	r.	r.	PROPN
admet-625	248	5	del	del	PROPN
admet-625	248	6	cont	cont	PROPN
admet-625	248	7	,	,	PUNCT
admet-625	248	8	m.	m.	NOUN
admet-625	248	9	abrami	abrami	PROPN
admet-625	248	10	,	,	PUNCT
admet-625	248	11	d.	d.	PROPN
admet-625	248	12	hasa	hasa	PROPN
admet-625	248	13	,	,	PUNCT
admet-625	248	14	b.	b.	PROPN
admet-625	248	15	perissutti	perissutti	PROPN
admet-625	248	16	,	,	PUNCT
admet-625	248	17	d.	d.	PROPN
admet-625	248	18	voinovich	voinovich	PROPN
admet-625	248	19	,	,	PUNCT
admet-625	248	20	a.	a.	PROPN
admet-625	248	21	barba	barba	PROPN
admet-625	248	22	,	,	PUNCT
admet-625	248	23	g.	g.	PROPN
admet-625	248	24	lamberti	lamberti	PROPN
admet-625	248	25	,	,	PUNCT
admet-625	248	26	g.	g.	PROPN
admet-625	248	27	grassi	grassi	PROPN
admet-625	248	28	,	,	PUNCT
admet-625	248	29	i.	i.	PROPN
admet-625	248	30	colombo	colombo	PROPN
admet-625	248	31	,	,	PUNCT
admet-625	248	32	d.	d.	PROPN
admet-625	248	33	manca	manca	PROPN
admet-625	248	34	,	,	PUNCT
admet-625	248	35	m.	m.	PROPN
admet-625	248	36	grassi	grassi	PROPN
admet-625	248	37	.	.	PUNCT
admet-625	249	1	a	a	DET
admet-625	249	2	physiologically	physiologically	ADV
admet-625	249	3	-	-	PUNCT
admet-625	249	4	oriented	orient	VERB
admet-625	249	5	mathematical	mathematical	ADJ
admet-625	249	6	model	model	NOUN
admet-625	249	7	for	for	ADP
admet-625	249	8	the	the	DET
admet-625	249	9	description	description	NOUN
admet-625	249	10	of	of	ADP
admet-625	249	11	in	in	ADP
admet-625	249	12	vivo	vivo	ADJ
admet-625	249	13	drug	drug	NOUN
admet-625	249	14	release	release	NOUN
admet-625	249	15	and	and	CCONJ
admet-625	249	16	absorption	absorption	NOUN
admet-625	249	17	.	.	PUNCT
admet-625	250	1	admet	admet	PROPN
admet-625	250	2	and	and	CCONJ
admet-625	250	3	dmpk	dmpk	X
admet-625	250	4	2	2	NUM
admet-625	250	5	(	(	PUNCT
admet-625	250	6	2014	2014	NUM
admet-625	250	7	)	)	PUNCT
admet-625	250	8	80	80	NUM
admet-625	250	9	-	-	SYM
admet-625	250	10	97	97	NUM
admet-625	250	11	.	.	PUNCT
admet-625	251	1	[	[	X
admet-625	251	2	12	12	NUM
admet-625	251	3	]	]	X
admet-625	251	4	j.r	j.r	PROPN
admet-625	251	5	.	.	PROPN
admet-625	251	6	calvo	calvo	PROPN
admet-625	251	7	,	,	PUNCT
admet-625	251	8	c.	c.	PROPN
admet-625	251	9	gonzález	gonzález	PROPN
admet-625	251	10	-	-	PUNCT
admet-625	251	11	yanes	yane	NOUN
admet-625	251	12	,	,	PUNCT
admet-625	251	13	m.d	m.d	PROPN
admet-625	251	14	.	.	PROPN
admet-625	251	15	maldonado	maldonado	PROPN
admet-625	251	16	.	.	PUNCT
admet-625	252	1	the	the	DET
admet-625	252	2	role	role	NOUN
admet-625	252	3	of	of	ADP
admet-625	252	4	melatonin	melatonin	NOUN
admet-625	252	5	in	in	ADP
admet-625	252	6	the	the	DET
admet-625	252	7	cells	cell	NOUN
admet-625	252	8	of	of	ADP
admet-625	252	9	the	the	DET
admet-625	252	10	innate	innate	ADJ
admet-625	252	11	immunity	immunity	NOUN
admet-625	252	12	:	:	PUNCT
admet-625	252	13	a	a	DET
admet-625	252	14	review	review	NOUN
admet-625	252	15	.	.	PUNCT
admet-625	253	1	j.	j.	PROPN
admet-625	253	2	pineal	pineal	PROPN
admet-625	253	3	res	re	NOUN
admet-625	253	4	.	.	PUNCT
admet-625	254	1	55	55	NUM
admet-625	254	2	(	(	PUNCT
admet-625	254	3	2013	2013	NUM
admet-625	254	4	)	)	PUNCT
admet-625	254	5	103	103	NUM
admet-625	254	6	-	-	SYM
admet-625	254	7	120	120	NUM
admet-625	254	8	.	.	PUNCT
admet-625	255	1	[	[	X
admet-625	255	2	13	13	NUM
admet-625	255	3	]	]	X
admet-625	255	4	d.	d.	PROPN
admet-625	255	5	tan	tan	PROPN
admet-625	255	6	,	,	PUNCT
admet-625	255	7	r.j	r.j	PROPN
admet-625	255	8	.	.	PROPN
admet-625	255	9	reiter	reiter	PROPN
admet-625	255	10	,	,	PUNCT
admet-625	255	11	l.c	l.c	PROPN
admet-625	255	12	.	.	PROPN
admet-625	255	13	manchester	manchester	PROPN
admet-625	255	14	,	,	PUNCT
admet-625	255	15	m.	m.	PROPN
admet-625	255	16	yan	yan	PROPN
admet-625	255	17	,	,	PUNCT
admet-625	255	18	m.	m.	PROPN
admet-625	255	19	el	el	PROPN
admet-625	255	20	-	-	PUNCT
admet-625	255	21	sawi	sawi	PROPN
admet-625	255	22	,	,	PUNCT
admet-625	255	23	r.m	r.m	PROPN
admet-625	255	24	.	.	PROPN
admet-625	255	25	sainz	sainz	PROPN
admet-625	255	26	,	,	PUNCT
admet-625	255	27	j.c	j.c	PROPN
admet-625	255	28	.	.	PROPN
admet-625	255	29	mayo	mayo	PROPN
admet-625	255	30	,	,	PUNCT
admet-625	255	31	r.	r.	PROPN
admet-625	255	32	kohen	kohen	PROPN
admet-625	255	33	,	,	PUNCT
admet-625	255	34	m.	m.	NOUN
admet-625	255	35	allegra	allegra	PROPN
admet-625	255	36	,	,	PUNCT
admet-625	255	37	r.	r.	PROPN
admet-625	255	38	hardeland	hardeland	PROPN
admet-625	255	39	.	.	PUNCT
admet-625	256	1	chemical	chemical	NOUN
admet-625	256	2	and	and	CCONJ
admet-625	256	3	physical	physical	ADJ
admet-625	256	4	properties	property	NOUN
admet-625	256	5	and	and	CCONJ
admet-625	256	6	potential	potential	ADJ
admet-625	256	7	mechanisms	mechanism	NOUN
admet-625	256	8	:	:	PUNCT
admet-625	256	9	melatonin	melatonin	NOUN
admet-625	256	10	as	as	ADP
admet-625	256	11	a	a	DET
admet-625	256	12	broad	broad	ADJ
admet-625	256	13	spectrum	spectrum	NOUN
admet-625	256	14	antioxidant	antioxidant	ADJ
admet-625	256	15	and	and	CCONJ
admet-625	256	16	free	free	ADJ
admet-625	256	17	radical	radical	ADJ
admet-625	256	18	scavenger	scavenger	NOUN
admet-625	256	19	.	.	PUNCT
admet-625	257	1	curr	curr	PROPN
admet-625	257	2	.	.	PUNCT
admet-625	257	3	top	top	PROPN
admet-625	257	4	.	.	PUNCT
admet-625	258	1	med	med	PROPN
admet-625	258	2	.	.	PUNCT
admet-625	258	3	chem	chem	PROPN
admet-625	258	4	.	.	PUNCT
admet-625	259	1	2	2	NUM
admet-625	259	2	(	(	PUNCT
admet-625	259	3	2002	2002	NUM
admet-625	259	4	)	)	PUNCT
admet-625	259	5	181	181	NUM
admet-625	259	6	-	-	SYM
admet-625	259	7	197	197	NUM
admet-625	259	8	.	.	PUNCT
admet-625	260	1	[	[	X
admet-625	260	2	14	14	NUM
admet-625	260	3	]	]	PUNCT
admet-625	260	4	k.	k.	PROPN
admet-625	260	5	celinski	celinski	PROPN
admet-625	260	6	,	,	PUNCT
admet-625	260	7	s.	s.	PROPN
admet-625	260	8	j.	j.	PROPN
admet-625	260	9	konturek	konturek	PROPN
admet-625	260	10	,	,	PUNCT
admet-625	260	11	p.c	p.c	PROPN
admet-625	260	12	.	.	PROPN
admet-625	260	13	konturek	konturek	PROPN
admet-625	260	14	,	,	PUNCT
admet-625	260	15	t.	t.	PROPN
admet-625	260	16	brzozowski	brzozowski	PROPN
admet-625	260	17	,	,	PUNCT
admet-625	260	18	h.	h.	PROPN
admet-625	260	19	cichoz‐lach	cichoz‐lach	PROPN
admet-625	260	20	,	,	PUNCT
admet-625	260	21	m.	m.	NOUN
admet-625	260	22	slomka	slomka	PROPN
admet-625	260	23	,	,	PUNCT
admet-625	260	24	p.	p.	NOUN
admet-625	260	25	malgorzata	malgorzata	PROPN
admet-625	260	26	,	,	PUNCT
admet-625	260	27	w.	w.	PROPN
admet-625	260	28	bielanski	bielanski	PROPN
admet-625	260	29	,	,	PUNCT
admet-625	260	30	r.j	r.j	PROPN
admet-625	260	31	.	.	PROPN
admet-625	260	32	reiter	reiter	PROPN
admet-625	260	33	.	.	PUNCT
admet-625	261	1	melatonin	melatonin	PROPN
admet-625	261	2	or	or	CCONJ
admet-625	261	3	l‐tryptophan	l‐tryptophan	NOUN
admet-625	261	4	accelerates	accelerate	VERB
admet-625	261	5	healing	healing	NOUN
admet-625	261	6	of	of	ADP
admet-625	261	7	gastroduodenal	gastroduodenal	ADJ
admet-625	261	8	ulcers	ulcer	NOUN
admet-625	261	9	in	in	ADP
admet-625	261	10	patients	patient	NOUN
admet-625	261	11	treated	treat	VERB
admet-625	261	12	with	with	ADP
admet-625	261	13	omeprazole	omeprazole	NOUN
admet-625	261	14	.	.	PUNCT
admet-625	262	1	j.	j.	PROPN
admet-625	262	2	pineal	pineal	PROPN
admet-625	262	3	res	re	NOUN
admet-625	262	4	.	.	PUNCT
admet-625	263	1	50	50	NUM
admet-625	263	2	(	(	PUNCT
admet-625	263	3	2011	2011	NUM
admet-625	263	4	)	)	PUNCT
admet-625	263	5	389	389	NUM
admet-625	263	6	-	-	SYM
admet-625	263	7	394	394	NUM
admet-625	263	8	.	.	PUNCT
admet-625	264	1	[	[	X
admet-625	264	2	15	15	NUM
admet-625	264	3	]	]	X
admet-625	264	4	s.	s.	PROPN
admet-625	264	5	r.	r.	PROPN
admet-625	264	6	pandi	pandi	PROPN
admet-625	264	7	-	-	PUNCT
admet-625	264	8	perumal	perumal	PROPN
admet-625	264	9	,	,	PUNCT
admet-625	264	10	i.	i.	NOUN
admet-625	264	11	trakht	trakht	NOUN
admet-625	264	12	,	,	PUNCT
admet-625	264	13	v.	v.	PROPN
admet-625	264	14	srinivasan	srinivasan	NOUN
admet-625	264	15	,	,	PUNCT
admet-625	264	16	d.	d.	PROPN
admet-625	264	17	w.	w.	PROPN
admet-625	264	18	spence	spence	PROPN
admet-625	264	19	,	,	PUNCT
admet-625	264	20	g.	g.	PROPN
admet-625	264	21	j.	j.	PROPN
admet-625	264	22	maestroni	maestroni	PROPN
admet-625	264	23	,	,	PUNCT
admet-625	264	24	n.	n.	PROPN
admet-625	264	25	zisapel	zisapel	PROPN
admet-625	264	26	,	,	PUNCT
admet-625	264	27	d.	d.	PROPN
admet-625	264	28	p.	p.	PROPN
admet-625	264	29	cardinali	cardinali	PROPN
admet-625	264	30	.	.	PUNCT
admet-625	265	1	physiological	physiological	ADJ
admet-625	265	2	effects	effect	NOUN
admet-625	265	3	of	of	ADP
admet-625	265	4	melatonin	melatonin	NOUN
admet-625	265	5	:	:	PUNCT
admet-625	265	6	role	role	NOUN
admet-625	265	7	of	of	ADP
admet-625	265	8	melatonin	melatonin	NOUN
admet-625	265	9	receptors	receptor	NOUN
admet-625	265	10	and	and	CCONJ
admet-625	265	11	signal	signal	ADJ
admet-625	265	12	transduction	transduction	NOUN
admet-625	265	13	pathways	pathway	NOUN
admet-625	265	14	.	.	PUNCT
admet-625	266	1	prog	prog	NOUN
admet-625	266	2	.	.	PUNCT
admet-625	267	1	neurobiol	neurobiol	PROPN
admet-625	267	2	.	.	PUNCT
admet-625	268	1	85	85	NUM
admet-625	268	2	(	(	PUNCT
admet-625	268	3	2008	2008	NUM
admet-625	268	4	)	)	PUNCT
admet-625	268	5	335	335	NUM
admet-625	268	6	-	-	SYM
admet-625	268	7	353	353	NUM
admet-625	268	8	.	.	PUNCT
admet-625	269	1	[	[	X
admet-625	269	2	16	16	NUM
admet-625	269	3	]	]	X
admet-625	269	4	r.m	r.m	PROPN
admet-625	269	5	.	.	PROPN
admet-625	269	6	slominski	slominski	PROPN
admet-625	269	7	,	,	PUNCT
admet-625	269	8	r.j	r.j	PROPN
admet-625	269	9	.	.	PROPN
admet-625	269	10	reiter	reiter	PROPN
admet-625	269	11	,	,	PUNCT
admet-625	269	12	n.	n.	PROPN
admet-625	269	13	schlabritz	schlabritz	PROPN
admet-625	269	14	-	-	PUNCT
admet-625	269	15	loutsevitch	loutsevitch	PROPN
admet-625	269	16	,	,	PUNCT
admet-625	269	17	r.s	r.s	PROPN
admet-625	269	18	.	.	PROPN
admet-625	269	19	ostrom	ostrom	PROPN
admet-625	269	20	,	,	PUNCT
admet-625	269	21	a.t	a.t	PROPN
admet-625	269	22	.	.	PROPN
admet-625	269	23	slominski	slominski	PROPN
admet-625	269	24	.	.	PUNCT
admet-625	270	1	melatonin	melatonin	NOUN
admet-625	270	2	membrane	membrane	NOUN
admet-625	270	3	receptors	receptor	NOUN
admet-625	270	4	in	in	ADP
admet-625	270	5	peripheral	peripheral	ADJ
admet-625	270	6	tissues	tissue	NOUN
admet-625	270	7	:	:	PUNCT
admet-625	270	8	distribution	distribution	NOUN
admet-625	270	9	and	and	CCONJ
admet-625	270	10	functions	function	NOUN
admet-625	270	11	.	.	PUNCT
admet-625	271	1	mol	mol	PROPN
admet-625	271	2	.	.	PROPN
admet-625	271	3	cell	cell	NOUN
admet-625	271	4	.	.	PUNCT
admet-625	272	1	endocrinol	endocrinol	NOUN
admet-625	272	2	.	.	PUNCT
admet-625	273	1	351	351	NUM
admet-625	273	2	(	(	PUNCT
admet-625	273	3	2012	2012	NUM
admet-625	273	4	)	)	PUNCT
admet-625	273	5	152	152	NUM
admet-625	273	6	-	-	SYM
admet-625	273	7	166	166	NUM
admet-625	273	8	.	.	PUNCT
admet-625	274	1	[	[	X
admet-625	274	2	17	17	NUM
admet-625	274	3	]	]	X
admet-625	274	4	r.j	r.j	PROPN
admet-625	274	5	.	.	PROPN
admet-625	274	6	reiter	reiter	PROPN
admet-625	274	7	,	,	PUNCT
admet-625	274	8	d.x	d.x	PROPN
admet-625	274	9	.	.	PROPN
admet-625	274	10	tan	tan	PROPN
admet-625	274	11	,	,	PUNCT
admet-625	274	12	a.	a.	NOUN
admet-625	274	13	galano	galano	PROPN
admet-625	274	14	.	.	PUNCT
admet-625	275	1	melatonin	melatonin	NOUN
admet-625	275	2	:	:	PUNCT
admet-625	275	3	exceeding	exceed	VERB
admet-625	275	4	expectations	expectation	NOUN
admet-625	275	5	.	.	PUNCT
admet-625	276	1	physiology	physiology	NOUN
admet-625	276	2	(	(	PUNCT
admet-625	276	3	bethesda	bethesda	NOUN
admet-625	276	4	)	)	PUNCT
admet-625	276	5	29	29	NUM
admet-625	276	6	(	(	PUNCT
admet-625	276	7	2014	2014	NUM
admet-625	276	8	)	)	PUNCT
admet-625	276	9	325	325	NUM
admet-625	276	10	-	-	SYM
admet-625	276	11	333	333	NUM
admet-625	276	12	.	.	PUNCT
admet-625	277	1	[	[	X
admet-625	277	2	18	18	NUM
admet-625	277	3	]	]	X
admet-625	277	4	p.f	p.f	PROPN
admet-625	277	5	.	.	PROPN
admet-625	277	6	innominato	innominato	PROPN
admet-625	277	7	,	,	PUNCT
admet-625	277	8	a.s	a.s	PROPN
admet-625	277	9	.	.	PROPN
admet-625	277	10	lim	lim	PROPN
admet-625	277	11	,	,	PUNCT
admet-625	277	12	o.	o.	PROPN
admet-625	277	13	palesh	palesh	PROPN
admet-625	277	14	,	,	PUNCT
admet-625	277	15	m.	m.	NOUN
admet-625	277	16	clemons	clemon	NOUN
admet-625	277	17	,	,	PUNCT
admet-625	277	18	m.	m.	NOUN
admet-625	277	19	trudeau	trudeau	NOUN
admet-625	277	20	,	,	PUNCT
admet-625	277	21	a.	a.	NOUN
admet-625	277	22	eisen	eisen	PROPN
admet-625	277	23	,	,	PUNCT
admet-625	277	24	c.	c.	PROPN
admet-625	277	25	wang	wang	PROPN
admet-625	277	26	,	,	PUNCT
admet-625	277	27	a.	a.	NOUN
admet-625	277	28	kiss	kiss	PROPN
admet-625	277	29	,	,	PUNCT
admet-625	277	30	k.i	k.i	PROPN
admet-625	277	31	.	.	PUNCT
admet-625	277	32	pritchard	pritchard	PROPN
admet-625	277	33	,	,	PUNCT
admet-625	277	34	g.a	g.a	PROPN
admet-625	277	35	.	.	PROPN
admet-625	277	36	bjarnason	bjarnason	PROPN
admet-625	277	37	.	.	PUNCT
admet-625	278	1	the	the	DET
admet-625	278	2	effect	effect	NOUN
admet-625	278	3	of	of	ADP
admet-625	278	4	melatonin	melatonin	NOUN
admet-625	278	5	on	on	ADP
admet-625	278	6	sleep	sleep	NOUN
admet-625	278	7	and	and	CCONJ
admet-625	278	8	quality	quality	NOUN
admet-625	278	9	of	of	ADP
admet-625	278	10	life	life	NOUN
admet-625	278	11	in	in	ADP
admet-625	278	12	patients	patient	NOUN
admet-625	278	13	with	with	ADP
admet-625	278	14	advanced	advanced	ADJ
admet-625	278	15	breast	breast	NOUN
admet-625	278	16	cancer	cancer	NOUN
admet-625	278	17	.	.	PUNCT
admet-625	279	1	support	support	NOUN
admet-625	279	2	care	care	NOUN
admet-625	279	3	cancer	cancer	NOUN
admet-625	279	4	24	24	NUM
admet-625	279	5	(	(	PUNCT
admet-625	279	6	2016	2016	NUM
admet-625	279	7	)	)	PUNCT
admet-625	279	8	1097	1097	NUM
admet-625	279	9	-	-	SYM
admet-625	279	10	1105	1105	NUM
admet-625	279	11	.	.	PUNCT
admet-625	280	1	[	[	X
admet-625	280	2	19	19	NUM
admet-625	280	3	]	]	PUNCT
admet-625	280	4	a.	a.	NOUN
admet-625	280	5	brzezinski	brzezinski	PROPN
admet-625	280	6	.	.	PUNCT
admet-625	281	1	melatonin	melatonin	NOUN
admet-625	281	2	in	in	ADP
admet-625	281	3	humans	human	NOUN
admet-625	281	4	.	.	PUNCT
admet-625	282	1	n.	n.	PROPN
admet-625	282	2	engl	engl	PROPN
admet-625	282	3	.	.	PUNCT
admet-625	283	1	j.	j.	PROPN
admet-625	283	2	med	med	PROPN
admet-625	283	3	.	.	PUNCT
admet-625	284	1	336	336	NUM
admet-625	284	2	(	(	PUNCT
admet-625	284	3	1997	1997	NUM
admet-625	284	4	)	)	PUNCT
admet-625	284	5	186	186	NUM
admet-625	284	6	-	-	SYM
admet-625	284	7	195	195	NUM
admet-625	284	8	.	.	PUNCT
admet-625	285	1	[	[	X
admet-625	285	2	20	20	NUM
admet-625	285	3	]	]	X
admet-625	285	4	g.	g.	PROPN
admet-625	285	5	mistraletti	mistraletti	PROPN
admet-625	285	6	,	,	PUNCT
admet-625	285	7	g.	g.	PROPN
admet-625	285	8	sabbatini	sabbatini	PROPN
admet-625	285	9	,	,	PUNCT
admet-625	285	10	m.	m.	PROPN
admet-625	285	11	taverna	taverna	PROPN
admet-625	285	12	,	,	PUNCT
admet-625	285	13	m.a	m.a	PROPN
admet-625	285	14	.	.	PROPN
admet-625	285	15	figini	figini	PROPN
admet-625	285	16	,	,	PUNCT
admet-625	285	17	m.	m.	NOUN
admet-625	285	18	umbrello	umbrello	PROPN
admet-625	285	19	,	,	PUNCT
admet-625	285	20	p.	p.	PROPN
admet-625	285	21	magni	magni	PROPN
admet-625	285	22	,	,	PUNCT
admet-625	285	23	m.	m.	NOUN
admet-625	285	24	ruscica	ruscica	PROPN
admet-625	285	25	,	,	PUNCT
admet-625	285	26	e.	e.	PROPN
admet-625	285	27	dozio	dozio	PROPN
admet-625	285	28	,	,	PUNCT
admet-625	285	29	r.	r.	PROPN
admet-625	285	30	esposti	esposti	PROPN
admet-625	285	31	,	,	PUNCT
admet-625	285	32	g.	g.	PROPN
admet-625	285	33	demartini	demartini	PROPN
admet-625	285	34	,	,	PUNCT
admet-625	285	35	f.	f.	PROPN
admet-625	285	36	fraschini	fraschini	PROPN
admet-625	285	37	,	,	PUNCT
admet-625	285	38	r.	r.	PROPN
admet-625	285	39	rezzani	rezzani	PROPN
admet-625	285	40	,	,	PUNCT
admet-625	285	41	r.j	r.j	PROPN
admet-625	285	42	.	.	PROPN
admet-625	285	43	reiter	reiter	PROPN
admet-625	285	44	,	,	PUNCT
admet-625	285	45	g.	g.	PROPN
admet-625	285	46	iapichino	iapichino	PROPN
admet-625	285	47	.	.	PUNCT
admet-625	286	1	pharmacokinetics	pharmacokinetic	NOUN
admet-625	286	2	of	of	ADP
admet-625	286	3	orally	orally	ADV
admet-625	286	4	administered	administer	VERB
admet-625	286	5	melatonin	melatonin	NOUN
admet-625	286	6	in	in	ADP
admet-625	286	7	critically	critically	ADV
admet-625	286	8	ill	ill	ADJ
admet-625	286	9	patients	patient	NOUN
admet-625	286	10	.	.	PUNCT
admet-625	287	1	j.	j.	PROPN
admet-625	287	2	pineal	pineal	PROPN
admet-625	287	3	res	re	NOUN
admet-625	287	4	.	.	PUNCT
admet-625	288	1	48	48	NUM
admet-625	288	2	(	(	PUNCT
admet-625	288	3	2010	2010	NUM
admet-625	288	4	)	)	PUNCT
admet-625	288	5	142	142	NUM
admet-625	288	6	-	-	SYM
admet-625	288	7	147	147	NUM
admet-625	288	8	.	.	PUNCT
admet-625	289	1	[	[	X
admet-625	289	2	21	21	NUM
admet-625	289	3	]	]	X
admet-625	289	4	r.t	r.t	PROPN
admet-625	289	5	.	.	PROPN
admet-625	289	6	dauchy	dauchy	PROPN
admet-625	289	7	,	,	PUNCT
admet-625	289	8	s.	s.	PROPN
admet-625	289	9	xiang	xiang	PROPN
admet-625	289	10	,	,	PUNCT
admet-625	289	11	l.	l.	PROPN
admet-625	289	12	mao	mao	PROPN
admet-625	289	13	,	,	PUNCT
admet-625	289	14	s.	s.	PROPN
admet-625	289	15	brimer	brimer	PROPN
admet-625	289	16	,	,	PUNCT
admet-625	289	17	m.a	m.a	PROPN
admet-625	289	18	.	.	PROPN
admet-625	289	19	wren	wren	PROPN
admet-625	289	20	,	,	PUNCT
admet-625	289	21	l.	l.	PROPN
admet-625	289	22	yuan	yuan	PROPN
admet-625	289	23	,	,	PUNCT
admet-625	289	24	m.	m.	NOUN
admet-625	289	25	anbalagan	anbalagan	PROPN
admet-625	289	26	,	,	PUNCT
admet-625	289	27	a.	a.	NOUN
admet-625	289	28	hauch	hauch	PROPN
admet-625	289	29	,	,	PUNCT
admet-625	289	30	t.	t.	PROPN
admet-625	289	31	frasch	frasch	PROPN
admet-625	289	32	,	,	PUNCT
admet-625	289	33	b.g	b.g	PROPN
admet-625	289	34	.	.	PROPN
admet-625	289	35	rowan	rowan	PROPN
admet-625	289	36	,	,	PUNCT
admet-625	289	37	d.e	d.e	PROPN
admet-625	289	38	.	.	PROPN
admet-625	289	39	blask	blask	PROPN
admet-625	289	40	,	,	PUNCT
admet-625	289	41	s.m	s.m	PROPN
admet-625	289	42	.	.	PROPN
admet-625	289	43	hill	hill	PROPN
admet-625	289	44	.	.	PUNCT
admet-625	290	1	circadian	circadian	PROPN
admet-625	290	2	and	and	CCONJ
admet-625	290	3	melatonin	melatonin	NOUN
admet-625	290	4	disruption	disruption	NOUN
admet-625	290	5	by	by	ADP
admet-625	290	6	exposure	exposure	NOUN
admet-625	290	7	to	to	ADP
admet-625	290	8	light	light	NOUN
admet-625	290	9	at	at	ADP
admet-625	290	10	night	night	NOUN
admet-625	290	11	drives	drive	VERB
admet-625	290	12	intrinsic	intrinsic	ADJ
admet-625	290	13	resistance	resistance	NOUN
admet-625	290	14	to	to	ADP
admet-625	290	15	tamoxifen	tamoxifen	NOUN
admet-625	290	16	therapy	therapy	NOUN
admet-625	290	17	in	in	ADP
admet-625	290	18	breast	breast	NOUN
admet-625	290	19	cancer	cancer	NOUN
admet-625	290	20	.	.	PUNCT
admet-625	291	1	cancer	cancer	NOUN
admet-625	291	2	res	re	NOUN
admet-625	291	3	.	.	PUNCT
admet-625	292	1	74	74	NUM
admet-625	292	2	(	(	PUNCT
admet-625	292	3	2014	2014	NUM
admet-625	292	4	)	)	PUNCT
admet-625	292	5	4099	4099	NUM
admet-625	292	6	-	-	SYM
admet-625	292	7	4110	4110	NUM
admet-625	292	8	.	.	PUNCT
admet-625	293	1	[	[	X
admet-625	293	2	22	22	NUM
admet-625	293	3	]	]	PUNCT
admet-625	293	4	a.	a.	NOUN
admet-625	293	5	damasceno	damasceno	PROPN
admet-625	293	6	,	,	PUNCT
admet-625	293	7	a.s	a.s	PROPN
admet-625	293	8	.	.	PROPN
admet-625	293	9	moraes	moraes	PROPN
admet-625	293	10	,	,	PUNCT
admet-625	293	11	a.	a.	NOUN
admet-625	293	12	farias	farias	PROPN
admet-625	293	13	,	,	PUNCT
admet-625	293	14	b.p	b.p	PROPN
admet-625	293	15	.	.	PROPN
admet-625	293	16	damasceno	damasceno	PROPN
admet-625	293	17	,	,	PUNCT
admet-625	293	18	l.m	l.m	PROPN
admet-625	293	19	.	.	PROPN
admet-625	293	20	dos	dos	PROPN
admet-625	293	21	santos	santos	PROPN
admet-625	293	22	,	,	PUNCT
admet-625	293	23	f.	f.	PROPN
admet-625	293	24	cendes	cendes	PROPN
admet-625	293	25	.	.	PUNCT
admet-625	294	1	disruption	disruption	NOUN
admet-625	294	2	of	of	ADP
admet-625	294	3	melatonin	melatonin	NOUN
admet-625	294	4	circadian	circadian	PROPN
admet-625	294	5	rhythm	rhythm	PROPN
admet-625	294	6	production	production	NOUN
admet-625	294	7	is	be	AUX
admet-625	294	8	related	relate	VERB
admet-625	294	9	to	to	ADP
admet-625	294	10	multiple	multiple	ADJ
admet-625	294	11	sclerosis	sclerosis	NOUN
admet-625	294	12	severity	severity	NOUN
admet-625	294	13	:	:	PUNCT
admet-625	294	14	a	a	DET
admet-625	294	15	preliminary	preliminary	ADJ
admet-625	294	16	study	study	NOUN
admet-625	294	17	.	.	PUNCT
admet-625	295	1	j.	j.	PROPN
admet-625	295	2	neurol	neurol	PROPN
admet-625	295	3	.	.	PUNCT
admet-625	296	1	sci	sci	PROPN
admet-625	296	2	.	.	PROPN
admet-625	297	1	353	353	NUM
admet-625	297	2	(	(	PUNCT
admet-625	297	3	2015	2015	NUM
admet-625	297	4	)	)	PUNCT
admet-625	297	5	166	166	NUM
admet-625	297	6	-	-	SYM
admet-625	297	7	168	168	NUM
admet-625	297	8	.	.	PUNCT
admet-625	298	1	[	[	X
admet-625	298	2	23	23	NUM
admet-625	298	3	]	]	X
admet-625	298	4	s.l	s.l	PROPN
admet-625	298	5	.	.	PROPN
admet-625	298	6	markantonis	markantonis	PROPN
admet-625	298	7	,	,	PUNCT
admet-625	298	8	e.	e.	PROPN
admet-625	298	9	tsakalozou	tsakalozou	PROPN
admet-625	298	10	,	,	PUNCT
admet-625	298	11	a.	a.	PROPN
admet-625	298	12	paraskeva	paraskeva	PROPN
admet-625	298	13	,	,	PUNCT
admet-625	298	14	c.	c.	PROPN
admet-625	298	15	staikou	staikou	PROPN
admet-625	298	16	,	,	PUNCT
admet-625	298	17	a.	a.	NOUN
admet-625	298	18	fassoulaki	fassoulaki	PROPN
admet-625	298	19	.	.	PUNCT
admet-625	299	1	melatonin	melatonin	NOUN
admet-625	299	2	pharmacokinetics	pharmacokinetic	NOUN
admet-625	299	3	in	in	ADP
admet-625	299	4	premenopausal	premenopausal	NOUN
admet-625	299	5	and	and	CCONJ
admet-625	299	6	postmenopausal	postmenopausal	ADJ
admet-625	299	7	healthy	healthy	ADJ
admet-625	299	8	female	female	ADJ
admet-625	299	9	volunteers	volunteer	NOUN
admet-625	299	10	.	.	PUNCT
admet-625	300	1	j.	j.	PROPN
admet-625	300	2	clin	clin	PROPN
admet-625	300	3	.	.	PUNCT
admet-625	301	1	pharmacol	pharmacol	PROPN
admet-625	301	2	.	.	PUNCT
admet-625	302	1	48	48	NUM
admet-625	302	2	(	(	PUNCT
admet-625	302	3	2008	2008	NUM
admet-625	302	4	)	)	PUNCT
admet-625	302	5	240	240	NUM
admet-625	302	6	-	-	SYM
admet-625	302	7	245	245	NUM
admet-625	302	8	.	.	PUNCT
admet-625	303	1	[	[	X
admet-625	303	2	24	24	NUM
admet-625	303	3	]	]	X
admet-625	303	4	g.	g.	PROPN
admet-625	303	5	mistraletti	mistraletti	PROPN
admet-625	303	6	,	,	PUNCT
admet-625	303	7	r.	r.	PROPN
admet-625	303	8	paroni	paroni	PROPN
admet-625	303	9	,	,	PUNCT
admet-625	303	10	m.	m.	NOUN
admet-625	303	11	umbrello	umbrello	PROPN
admet-625	303	12	,	,	PUNCT
admet-625	303	13	l.	l.	PROPN
admet-625	303	14	d'amato	d'amato	PROPN
admet-625	303	15	,	,	PUNCT
admet-625	303	16	g.	g.	PROPN
admet-625	303	17	sabbatini	sabbatini	PROPN
admet-625	303	18	,	,	PUNCT
admet-625	303	19	m.	m.	NOUN
admet-625	303	20	taverna	taverna	PROPN
admet-625	303	21	,	,	PUNCT
admet-625	303	22	p.	p.	PROPN
admet-625	303	23	formenti	formenti	PROPN
admet-625	303	24	,	,	PUNCT
admet-625	303	25	e.	e.	PROPN
admet-625	303	26	finati	finati	PROPN
admet-625	303	27	,	,	PUNCT
admet-625	303	28	g.	g.	PROPN
admet-625	303	29	favero	favero	PROPN
admet-625	303	30	,	,	PUNCT
admet-625	303	31	f.	f.	PROPN
admet-625	303	32	bonomini	bonomini	PROPN
admet-625	303	33	,	,	PUNCT
admet-625	303	34	r.	r.	PROPN
admet-625	303	35	rezzani	rezzani	PROPN
admet-625	303	36	,	,	PUNCT
admet-625	303	37	r.j	r.j	PROPN
admet-625	303	38	.	.	PROPN
admet-625	303	39	reiter	reiter	PROPN
admet-625	303	40	,	,	PUNCT
admet-625	303	41	g.	g.	PROPN
admet-625	303	42	iapichino	iapichino	PROPN
admet-625	303	43	.	.	PUNCT
admet-625	304	1	melatonin	melatonin	PROPN
admet-625	304	2	pharmacological	pharmacological	NOUN
admet-625	304	3	blood	blood	NOUN
admet-625	304	4	levels	level	NOUN
admet-625	304	5	increase	increase	VERB
admet-625	304	6	total	total	ADJ
admet-625	304	7	antioxidant	antioxidant	ADJ
admet-625	304	8	capacity	capacity	NOUN
admet-625	304	9	in	in	ADP
admet-625	304	10	critically	critically	ADV
admet-625	304	11	ill	ill	ADJ
admet-625	304	12	patients	patient	NOUN
admet-625	304	13	.	.	PUNCT
admet-625	305	1	int	int	NOUN
admet-625	305	2	.	.	PUNCT
admet-625	306	1	j.	j.	PROPN
admet-625	306	2	mol	mol	PROPN
admet-625	306	3	.	.	PUNCT
admet-625	307	1	sci	sci	PROPN
admet-625	307	2	.	.	PROPN
admet-625	307	3	18	18	NUM
admet-625	307	4	(	(	PUNCT
admet-625	307	5	2017	2017	NUM
admet-625	307	6	)	)	PUNCT
admet-625	307	7	e759	e759	PROPN
admet-625	307	8	.	.	PUNCT
admet-625	308	1	savoca	savoca	PROPN
admet-625	308	2	and	and	CCONJ
admet-625	308	3	manca	manca	PROPN
admet-625	308	4	admet	admet	PROPN
admet-625	308	5	&	&	CCONJ
admet-625	308	6	dmpk	dmpk	PROPN
admet-625	308	7	7(1	7(1	PROPN
admet-625	308	8	)	)	PUNCT
admet-625	308	9	(	(	PUNCT
admet-625	308	10	2019	2019	NUM
admet-625	308	11	)	)	PUNCT
admet-625	308	12	44	44	NUM
admet-625	308	13	-	-	SYM
admet-625	308	14	59	59	NUM
admet-625	308	15	58	58	NUM
admet-625	309	1	[	[	X
admet-625	309	2	25	25	NUM
admet-625	309	3	]	]	X
admet-625	309	4	h.f	h.f	PROPN
admet-625	309	5	.	.	PROPN
admet-625	309	6	galley	galley	NOUN
admet-625	309	7	,	,	PUNCT
admet-625	309	8	d.a	d.a	PROPN
admet-625	309	9	.	.	PROPN
admet-625	309	10	lowes	lowes	PROPN
admet-625	309	11	,	,	PUNCT
admet-625	309	12	l.	l.	PROPN
admet-625	309	13	allen	allen	PROPN
admet-625	309	14	,	,	PUNCT
admet-625	309	15	g.	g.	PROPN
admet-625	309	16	cameron	cameron	PROPN
admet-625	309	17	,	,	PUNCT
admet-625	309	18	l.s	l.s	PROPN
admet-625	309	19	.	.	PROPN
admet-625	309	20	aucott	aucott	PROPN
admet-625	309	21	,	,	PUNCT
admet-625	309	22	n.r	n.r	PROPN
admet-625	309	23	.	.	PROPN
admet-625	309	24	webster	webster	PROPN
admet-625	309	25	.	.	PUNCT
admet-625	310	1	melatonin	melatonin	PROPN
admet-625	310	2	as	as	ADP
admet-625	310	3	a	a	DET
admet-625	310	4	potential	potential	ADJ
admet-625	310	5	therapy	therapy	NOUN
admet-625	310	6	for	for	ADP
admet-625	310	7	sepsis	sepsis	NOUN
admet-625	310	8	:	:	PUNCT
admet-625	310	9	a	a	DET
admet-625	310	10	phase	phase	NOUN
admet-625	310	11	i	i	PRON
admet-625	310	12	dose	dose	VERB
admet-625	310	13	escalation	escalation	NOUN
admet-625	310	14	study	study	NOUN
admet-625	310	15	and	and	CCONJ
admet-625	310	16	an	an	DET
admet-625	310	17	ex	ex	ADJ
admet-625	310	18	vivo	vivo	ADJ
admet-625	310	19	whole	whole	ADJ
admet-625	310	20	blood	blood	NOUN
admet-625	310	21	model	model	NOUN
admet-625	310	22	under	under	ADP
admet-625	310	23	conditions	condition	NOUN
admet-625	310	24	of	of	ADP
admet-625	310	25	sepsis	sepsis	NOUN
admet-625	310	26	.	.	PUNCT
admet-625	311	1	j.	j.	PROPN
admet-625	311	2	pineal	pineal	PROPN
admet-625	311	3	res	re	NOUN
admet-625	311	4	.	.	PUNCT
admet-625	312	1	56	56	NUM
admet-625	312	2	(	(	PUNCT
admet-625	312	3	2014	2014	NUM
admet-625	312	4	)	)	PUNCT
admet-625	312	5	427	427	NUM
admet-625	312	6	-	-	SYM
admet-625	312	7	438	438	NUM
admet-625	312	8	.	.	PUNCT
admet-625	313	1	[	[	X
admet-625	313	2	26	26	NUM
admet-625	313	3	]	]	X
admet-625	313	4	n.s	n.s	PROPN
admet-625	313	5	.	.	PROPN
admet-625	313	6	gooneratne	gooneratne	PROPN
admet-625	313	7	,	,	PUNCT
admet-625	313	8	a.y	a.y	PROPN
admet-625	313	9	.	.	PROPN
admet-625	313	10	edwards	edwards	PROPN
admet-625	313	11	,	,	PUNCT
admet-625	313	12	c.	c.	PROPN
admet-625	313	13	zhou	zhou	PROPN
admet-625	313	14	,	,	PUNCT
admet-625	313	15	n.	n.	PROPN
admet-625	313	16	cuellar	cuellar	PROPN
admet-625	313	17	,	,	PUNCT
admet-625	313	18	m.a	m.a	PROPN
admet-625	313	19	.	.	PROPN
admet-625	313	20	grandner	grandner	PROPN
admet-625	313	21	,	,	PUNCT
admet-625	313	22	j.s	j.s	PROPN
admet-625	313	23	.	.	PROPN
admet-625	313	24	barrett	barrett	PROPN
admet-625	313	25	.	.	PROPN
admet-625	314	1	melatonin	melatonin	PROPN
admet-625	314	2	pharmacokinetics	pharmacokinetic	NOUN
admet-625	314	3	following	follow	VERB
admet-625	314	4	two	two	NUM
admet-625	314	5	different	different	ADJ
admet-625	314	6	oral	oral	ADJ
admet-625	314	7	surge	surge	NOUN
admet-625	314	8	-	-	PUNCT
admet-625	314	9	sustained	sustain	VERB
admet-625	314	10	release	release	NOUN
admet-625	314	11	doses	dose	NOUN
admet-625	314	12	in	in	ADP
admet-625	314	13	older	old	ADJ
admet-625	314	14	adults	adult	NOUN
admet-625	314	15	.	.	PUNCT
admet-625	315	1	j.	j.	PROPN
admet-625	315	2	pineal	pineal	PROPN
admet-625	315	3	res	re	NOUN
admet-625	315	4	.	.	PUNCT
admet-625	316	1	52	52	NUM
admet-625	316	2	(	(	PUNCT
admet-625	316	3	2012	2012	NUM
admet-625	316	4	)	)	PUNCT
admet-625	316	5	437	437	NUM
admet-625	316	6	-	-	SYM
admet-625	316	7	445	445	NUM
admet-625	316	8	.	.	PUNCT
admet-625	317	1	[	[	X
admet-625	317	2	27	27	NUM
admet-625	317	3	]	]	X
admet-625	317	4	h.t	h.t	PROPN
admet-625	317	5	.	.	PROPN
admet-625	317	6	peng	peng	PROPN
admet-625	317	7	,	,	PUNCT
admet-625	317	8	f.	f.	PROPN
admet-625	317	9	bouak	bouak	PROPN
admet-625	317	10	,	,	PUNCT
admet-625	317	11	o.	o.	PROPN
admet-625	317	12	vartanian	vartanian	PROPN
admet-625	317	13	,	,	PUNCT
admet-625	317	14	b.	b.	PROPN
admet-625	317	15	cheung	cheung	PROPN
admet-625	317	16	.	.	PUNCT
admet-625	318	1	a	a	DET
admet-625	318	2	physiologically	physiologically	ADV
admet-625	318	3	based	base	VERB
admet-625	318	4	pharmacokinetics	pharmacokinetic	NOUN
admet-625	318	5	model	model	NOUN
admet-625	318	6	for	for	ADP
admet-625	318	7	melatonin	melatonin	NOUN
admet-625	318	8	--	--	PUNCT
admet-625	318	9	effects	effect	NOUN
admet-625	318	10	of	of	ADP
admet-625	318	11	light	light	NOUN
admet-625	318	12	and	and	CCONJ
admet-625	318	13	routes	route	NOUN
admet-625	318	14	of	of	ADP
admet-625	318	15	administration	administration	NOUN
admet-625	318	16	.	.	PUNCT
admet-625	319	1	int	int	NOUN
admet-625	319	2	.	.	PUNCT
admet-625	320	1	j.	j.	PROPN
admet-625	320	2	pharm	pharm	PROPN
admet-625	320	3	.	.	PUNCT
admet-625	321	1	458	458	NUM
admet-625	321	2	(	(	PUNCT
admet-625	321	3	2013	2013	NUM
admet-625	321	4	)	)	PUNCT
admet-625	321	5	156	156	NUM
admet-625	321	6	-	-	SYM
admet-625	321	7	168	168	NUM
admet-625	321	8	.	.	PUNCT
admet-625	322	1	[	[	X
admet-625	322	2	28	28	NUM
admet-625	322	3	]	]	X
admet-625	322	4	r.a	r.a	PROPN
admet-625	322	5	.	.	PROPN
admet-625	322	6	abbiati	abbiati	PROPN
admet-625	322	7	,	,	PUNCT
admet-625	322	8	g.	g.	PROPN
admet-625	322	9	lamberti	lamberti	PROPN
admet-625	322	10	,	,	PUNCT
admet-625	322	11	m.	m.	NOUN
admet-625	322	12	grassi	grassi	PROPN
admet-625	322	13	,	,	PUNCT
admet-625	322	14	f.	f.	PROPN
admet-625	322	15	trotta	trotta	PROPN
admet-625	322	16	,	,	PUNCT
admet-625	322	17	d.	d.	PROPN
admet-625	322	18	manca	manca	PROPN
admet-625	322	19	.	.	PUNCT
admet-625	323	1	definition	definition	NOUN
admet-625	323	2	and	and	CCONJ
admet-625	323	3	validation	validation	NOUN
admet-625	323	4	of	of	ADP
admet-625	323	5	a	a	DET
admet-625	323	6	patientindividualized	patientindividualize	VERB
admet-625	323	7	physiologically	physiologically	ADV
admet-625	323	8	-	-	PUNCT
admet-625	323	9	based	base	VERB
admet-625	323	10	pharmacokinetic	pharmacokinetic	ADJ
admet-625	323	11	model	model	NOUN
admet-625	323	12	.	.	PUNCT
admet-625	324	1	comput	comput	NOUN
admet-625	324	2	.	.	PUNCT
admet-625	325	1	chem	chem	NOUN
admet-625	325	2	.	.	PUNCT
admet-625	326	1	eng	eng	PROPN
admet-625	326	2	.	.	PROPN
admet-625	326	3	84	84	NUM
admet-625	326	4	(	(	PUNCT
admet-625	326	5	2016	2016	NUM
admet-625	326	6	)	)	PUNCT
admet-625	326	7	394408	394408	NUM
admet-625	326	8	.	.	PUNCT
admet-625	327	1	[	[	X
admet-625	327	2	29	29	NUM
admet-625	327	3	]	]	X
admet-625	327	4	s.i	s.i	PROPN
admet-625	327	5	.	.	PROPN
admet-625	327	6	shirakawa	shirakawa	PROPN
admet-625	327	7	,	,	PUNCT
admet-625	327	8	s.	s.	PROPN
admet-625	327	9	tsuchiya	tsuchiya	PROPN
admet-625	327	10	,	,	PUNCT
admet-625	327	11	y.	y.	PROPN
admet-625	327	12	tsutsumi	tsutsumi	PROPN
admet-625	327	13	,	,	PUNCT
admet-625	327	14	t.	t.	PROPN
admet-625	327	15	kotorii	kotorii	PROPN
admet-625	327	16	,	,	PUNCT
admet-625	327	17	n.	n.	PROPN
admet-625	327	18	uchimura	uchimura	NOUN
admet-625	327	19	,	,	PUNCT
admet-625	327	20	t.	t.	PROPN
admet-625	327	21	sakamoto	sakamoto	PROPN
admet-625	327	22	,	,	PUNCT
admet-625	327	23	s.	s.	PROPN
admet-625	327	24	yamada	yamada	PROPN
admet-625	327	25	.	.	PROPN
admet-625	327	26	time	time	NOUN
admet-625	327	27	course	course	NOUN
admet-625	327	28	of	of	ADP
admet-625	327	29	saliva	saliva	NOUN
admet-625	327	30	and	and	CCONJ
admet-625	327	31	serum	serum	NOUN
admet-625	327	32	melatonin	melatonin	NOUN
admet-625	327	33	levels	level	NOUN
admet-625	327	34	after	after	ADP
admet-625	327	35	ingestion	ingestion	NOUN
admet-625	327	36	of	of	ADP
admet-625	327	37	melatonin	melatonin	NOUN
admet-625	327	38	.	.	PUNCT
admet-625	328	1	psychiatry	psychiatry	NOUN
admet-625	328	2	and	and	CCONJ
admet-625	328	3	clinical	clinical	ADJ
admet-625	328	4	neurosciences	neuroscience	NOUN
admet-625	328	5	52	52	NUM
admet-625	328	6	(	(	PUNCT
admet-625	328	7	1998	1998	NUM
admet-625	328	8	)	)	PUNCT
admet-625	328	9	266	266	NUM
admet-625	328	10	-	-	SYM
admet-625	328	11	267	267	NUM
admet-625	328	12	.	.	PUNCT
admet-625	329	1	[	[	X
admet-625	329	2	30	30	NUM
admet-625	329	3	]	]	X
admet-625	329	4	m.l	m.l	PROPN
admet-625	329	5	.	.	PROPN
admet-625	329	6	laakso	laakso	PROPN
admet-625	329	7	,	,	PUNCT
admet-625	329	8	t.	t.	PROPN
admet-625	329	9	hätönen	hätönen	PROPN
admet-625	329	10	,	,	PUNCT
admet-625	329	11	d.	d.	PROPN
admet-625	329	12	stenberg	stenberg	PROPN
admet-625	329	13	,	,	PUNCT
admet-625	329	14	a.	a.	PROPN
admet-625	329	15	alila	alila	PROPN
admet-625	329	16	,	,	PUNCT
admet-625	329	17	s.	s.	PROPN
admet-625	329	18	smith	smith	PROPN
admet-625	329	19	.	.	PUNCT
admet-625	330	1	one	one	NUM
admet-625	330	2	-	-	PUNCT
admet-625	330	3	hour	hour	NOUN
admet-625	330	4	exposure	exposure	NOUN
admet-625	330	5	to	to	ADP
admet-625	330	6	moderate	moderate	ADJ
admet-625	330	7	illuminance	illuminance	NOUN
admet-625	330	8	(	(	PUNCT
admet-625	330	9	500	500	NUM
admet-625	330	10	lux	lux	NOUN
admet-625	330	11	)	)	PUNCT
admet-625	330	12	shifts	shift	NOUN
admet-625	330	13	the	the	DET
admet-625	330	14	human	human	ADJ
admet-625	330	15	melatonin	melatonin	NOUN
admet-625	330	16	rhythm	rhythm	NOUN
admet-625	330	17	.	.	PUNCT
admet-625	331	1	j.	j.	PROPN
admet-625	331	2	pineal	pineal	PROPN
admet-625	331	3	res	re	NOUN
admet-625	331	4	.	.	PROPN
admet-625	332	1	15	15	NUM
admet-625	332	2	(	(	PUNCT
admet-625	332	3	1993	1993	NUM
admet-625	332	4	)	)	PUNCT
admet-625	332	5	21	21	NUM
admet-625	332	6	-	-	SYM
admet-625	332	7	26	26	NUM
admet-625	332	8	.	.	PUNCT
admet-625	333	1	[	[	X
admet-625	333	2	31	31	NUM
admet-625	333	3	]	]	PUNCT
admet-625	333	4	s.	s.	PROPN
admet-625	333	5	benloucif	benloucif	PROPN
admet-625	333	6	,	,	PUNCT
admet-625	333	7	h.j	h.j	PROPN
admet-625	333	8	.	.	PROPN
admet-625	333	9	burgess	burgess	PROPN
admet-625	333	10	,	,	PUNCT
admet-625	333	11	e.b	e.b	PROPN
admet-625	333	12	.	.	PROPN
admet-625	333	13	klerman	klerman	PROPN
admet-625	333	14	,	,	PUNCT
admet-625	333	15	a.j	a.j	PROPN
admet-625	333	16	.	.	PROPN
admet-625	333	17	lewy	lewy	PROPN
admet-625	333	18	,	,	PUNCT
admet-625	333	19	b.	b.	PROPN
admet-625	333	20	middleton	middleton	PROPN
admet-625	333	21	,	,	PUNCT
admet-625	333	22	p.j	p.j	PROPN
admet-625	333	23	.	.	PROPN
admet-625	333	24	murphy	murphy	PROPN
admet-625	333	25	,	,	PUNCT
admet-625	333	26	b.l	b.l	PROPN
admet-625	333	27	.	.	PROPN
admet-625	333	28	parry	parry	PROPN
admet-625	333	29	,	,	PUNCT
admet-625	333	30	v.l	v.l	PROPN
admet-625	333	31	.	.	PROPN
admet-625	333	32	revell	revell	PROPN
admet-625	333	33	.	.	PUNCT
admet-625	334	1	measuring	measure	VERB
admet-625	334	2	melatonin	melatonin	NOUN
admet-625	334	3	in	in	ADP
admet-625	334	4	humans	human	NOUN
admet-625	334	5	.	.	PUNCT
admet-625	335	1	j.	j.	PROPN
admet-625	335	2	clin	clin	PROPN
admet-625	335	3	.	.	PUNCT
admet-625	336	1	sleep	sleep	PROPN
admet-625	336	2	med	me	VERB
admet-625	336	3	.	.	PUNCT
admet-625	337	1	4	4	NUM
admet-625	337	2	(	(	PUNCT
admet-625	337	3	2008	2008	NUM
admet-625	337	4	)	)	PUNCT
admet-625	337	5	66	66	NUM
admet-625	337	6	-	-	SYM
admet-625	337	7	69	69	NUM
admet-625	337	8	.	.	PUNCT
admet-625	338	1	[	[	X
admet-625	338	2	32	32	NUM
admet-625	338	3	]	]	PUNCT
admet-625	338	4	a.	a.	NOUN
admet-625	338	5	voultsios	voultsios	PROPN
admet-625	338	6	,	,	PUNCT
admet-625	338	7	d.j	d.j	PROPN
admet-625	338	8	.	.	PROPN
admet-625	338	9	kennaway	kennaway	PROPN
admet-625	338	10	,	,	PUNCT
admet-625	338	11	d.	d.	PROPN
admet-625	338	12	dawson	dawson	PROPN
admet-625	338	13	.	.	PROPN
admet-625	339	1	salivary	salivary	VERB
admet-625	339	2	melatonin	melatonin	NOUN
admet-625	339	3	as	as	ADP
admet-625	339	4	a	a	DET
admet-625	339	5	circadian	circadian	ADJ
admet-625	339	6	phase	phase	NOUN
admet-625	339	7	marker	marker	NOUN
admet-625	339	8	:	:	PUNCT
admet-625	339	9	validation	validation	NOUN
admet-625	339	10	and	and	CCONJ
admet-625	339	11	comparison	comparison	NOUN
admet-625	339	12	to	to	ADP
admet-625	339	13	plasma	plasma	NOUN
admet-625	339	14	melatonin	melatonin	NOUN
admet-625	339	15	.	.	PUNCT
admet-625	340	1	j.	j.	PROPN
admet-625	340	2	biol	biol	PROPN
admet-625	340	3	.	.	PUNCT
admet-625	341	1	rhythms	rhythm	NOUN
admet-625	341	2	12	12	NUM
admet-625	341	3	(	(	PUNCT
admet-625	341	4	1997	1997	NUM
admet-625	341	5	)	)	PUNCT
admet-625	341	6	457	457	NUM
admet-625	341	7	-	-	SYM
admet-625	341	8	466	466	NUM
admet-625	341	9	.	.	PUNCT
admet-625	342	1	[	[	X
admet-625	342	2	33	33	NUM
admet-625	342	3	]	]	X
admet-625	342	4	r.l	r.l	PROPN
admet-625	342	5	.	.	PROPN
admet-625	342	6	demuro	demuro	PROPN
admet-625	342	7	,	,	PUNCT
admet-625	342	8	a.n	a.n	PROPN
admet-625	342	9	.	.	PROPN
admet-625	342	10	nafziger	nafziger	PROPN
admet-625	342	11	,	,	PUNCT
admet-625	342	12	d.e	d.e	PROPN
admet-625	342	13	.	.	PROPN
admet-625	342	14	blask	blask	PROPN
admet-625	342	15	,	,	PUNCT
admet-625	342	16	a.m.	a.m.	PROPN
admet-625	342	17	menhinick	menhinick	PROPN
admet-625	342	18	,	,	PUNCT
admet-625	342	19	j.s	j.s	PROPN
admet-625	342	20	.	.	PROPN
admet-625	342	21	bertino	bertino	PROPN
admet-625	342	22	,	,	PUNCT
admet-625	342	23	jr	jr	PROPN
admet-625	342	24	.	.	PUNCT
admet-625	343	1	the	the	DET
admet-625	343	2	absolute	absolute	ADJ
admet-625	343	3	bioavailability	bioavailability	NOUN
admet-625	343	4	of	of	ADP
admet-625	343	5	oral	oral	ADJ
admet-625	343	6	melatonin	melatonin	NOUN
admet-625	343	7	.	.	PUNCT
admet-625	344	1	j.	j.	PROPN
admet-625	344	2	clin	clin	PROPN
admet-625	344	3	.	.	PUNCT
admet-625	345	1	pharmacol	pharmacol	PROPN
admet-625	345	2	.	.	PROPN
admet-625	346	1	40	40	NUM
admet-625	346	2	(	(	PUNCT
admet-625	346	3	2000	2000	NUM
admet-625	346	4	)	)	PUNCT
admet-625	347	1	781	781	NUM
admet-625	347	2	-	-	SYM
admet-625	347	3	784	784	NUM
admet-625	347	4	.	.	PUNCT
admet-625	348	1	[	[	X
admet-625	348	2	34	34	NUM
admet-625	348	3	]	]	X
admet-625	348	4	l.p.h	l.p.h	PROPN
admet-625	348	5	.	.	PUNCT
admet-625	348	6	andersen	andersen	PROPN
admet-625	348	7	,	,	PUNCT
admet-625	348	8	m.u	m.u	PROPN
admet-625	348	9	.	.	PROPN
admet-625	348	10	werner	werner	PROPN
admet-625	348	11	,	,	PUNCT
admet-625	348	12	m.m	m.m	PROPN
admet-625	348	13	.	.	PROPN
admet-625	348	14	rosenkilde	rosenkilde	PROPN
admet-625	348	15	,	,	PUNCT
admet-625	348	16	n.g	n.g	PROPN
admet-625	348	17	.	.	PROPN
admet-625	348	18	harpsøe	harpsøe	PROPN
admet-625	348	19	,	,	PUNCT
admet-625	348	20	h.	h.	PROPN
admet-625	348	21	fuglsang	fuglsang	PROPN
admet-625	348	22	,	,	PUNCT
admet-625	348	23	j.	j.	PROPN
admet-625	348	24	rosenberg	rosenberg	PROPN
admet-625	348	25	,	,	PUNCT
admet-625	348	26	i.	i.	PROPN
admet-625	348	27	gögenur	gögenur	PROPN
admet-625	348	28	.	.	PUNCT
admet-625	349	1	pharmacokinetics	pharmacokinetic	NOUN
admet-625	349	2	of	of	ADP
admet-625	349	3	oral	oral	ADJ
admet-625	349	4	and	and	CCONJ
admet-625	349	5	intravenous	intravenous	ADJ
admet-625	349	6	melatonin	melatonin	NOUN
admet-625	349	7	in	in	ADP
admet-625	349	8	healthy	healthy	ADJ
admet-625	349	9	volunteers	volunteer	NOUN
admet-625	349	10	.	.	PUNCT
admet-625	350	1	bmc	bmc	PROPN
admet-625	350	2	pharmacol	pharmacol	PROPN
admet-625	350	3	.	.	PUNCT
admet-625	351	1	toxicol	toxicol	PROPN
admet-625	351	2	.	.	PUNCT
admet-625	352	1	17	17	NUM
admet-625	352	2	(	(	PUNCT
admet-625	352	3	2016	2016	NUM
admet-625	352	4	)	)	PUNCT
admet-625	352	5	8	8	NUM
admet-625	352	6	.	.	PUNCT
admet-625	353	1	[	[	X
admet-625	353	2	35	35	NUM
admet-625	353	3	]	]	X
admet-625	353	4	l.	l.	PROPN
admet-625	353	5	benes	benes	PROPN
admet-625	353	6	,	,	PUNCT
admet-625	353	7	b.	b.	PROPN
admet-625	353	8	claustrat	claustrat	PROPN
admet-625	353	9	,	,	PUNCT
admet-625	353	10	f.	f.	PROPN
admet-625	353	11	horriere	horriere	PROPN
admet-625	353	12	,	,	PUNCT
admet-625	353	13	m.	m.	NOUN
admet-625	353	14	geoffriau	geoffriau	PROPN
admet-625	353	15	,	,	PUNCT
admet-625	353	16	j.	j.	PROPN
admet-625	353	17	konsil	konsil	PROPN
admet-625	353	18	,	,	PUNCT
admet-625	353	19	k.a	k.a	PROPN
admet-625	353	20	.	.	PUNCT
admet-625	353	21	parrott	parrott	PROPN
admet-625	353	22	,	,	PUNCT
admet-625	353	23	g.	g.	PROPN
admet-625	353	24	degrande	degrande	PROPN
admet-625	353	25	,	,	PUNCT
admet-625	353	26	r.l	r.l	PROPN
admet-625	353	27	.	.	PROPN
admet-625	353	28	mcquinn	mcquinn	PROPN
admet-625	353	29	,	,	PUNCT
admet-625	353	30	j.w	j.w	PROPN
admet-625	353	31	.	.	PROPN
admet-625	353	32	ayres	ayres	PROPN
admet-625	353	33	.	.	PUNCT
admet-625	354	1	transmucosal	transmucosal	ADJ
admet-625	354	2	,	,	PUNCT
admet-625	354	3	oral	oral	ADJ
admet-625	354	4	controlled	control	VERB
admet-625	354	5	-	-	PUNCT
admet-625	354	6	release	release	NOUN
admet-625	354	7	,	,	PUNCT
admet-625	354	8	and	and	CCONJ
admet-625	354	9	transdermal	transdermal	ADJ
admet-625	354	10	drug	drug	NOUN
admet-625	354	11	administration	administration	NOUN
admet-625	354	12	in	in	ADP
admet-625	354	13	human	human	ADJ
admet-625	354	14	subjects	subject	NOUN
admet-625	354	15	:	:	PUNCT
admet-625	354	16	a	a	DET
admet-625	354	17	crossover	crossover	NOUN
admet-625	354	18	study	study	NOUN
admet-625	354	19	with	with	ADP
admet-625	354	20	melatonin	melatonin	NOUN
admet-625	354	21	.	.	PUNCT
admet-625	355	1	j.	j.	PROPN
admet-625	355	2	pharm	pharm	PROPN
admet-625	355	3	.	.	PUNCT
admet-625	356	1	sci	sci	PROPN
admet-625	356	2	.	.	PROPN
admet-625	357	1	86	86	NUM
admet-625	357	2	(	(	PUNCT
admet-625	357	3	1997	1997	NUM
admet-625	357	4	)	)	PUNCT
admet-625	357	5	1115	1115	NUM
admet-625	357	6	-	-	SYM
admet-625	357	7	1119	1119	NUM
admet-625	357	8	.	.	PUNCT
admet-625	358	1	[	[	X
admet-625	358	2	36	36	NUM
admet-625	358	3	]	]	X
admet-625	358	4	b.j	b.j	PROPN
admet-625	358	5	.	.	PROPN
admet-625	358	6	lee	lee	PROPN
admet-625	358	7	,	,	PUNCT
admet-625	358	8	k.a	k.a	PROPN
admet-625	358	9	.	.	PUNCT
admet-625	358	10	parrott	parrott	PROPN
admet-625	358	11	,	,	PUNCT
admet-625	358	12	j.w	j.w	PROPN
admet-625	358	13	.	.	PROPN
admet-625	358	14	ayres	ayres	PROPN
admet-625	358	15	,	,	PUNCT
admet-625	358	16	r.l	r.l	PROPN
admet-625	358	17	.	.	PROPN
admet-625	358	18	sack	sack	PROPN
admet-625	358	19	.	.	PUNCT
admet-625	359	1	development	development	NOUN
admet-625	359	2	and	and	CCONJ
admet-625	359	3	characterization	characterization	NOUN
admet-625	359	4	of	of	ADP
admet-625	359	5	an	an	DET
admet-625	359	6	oral	oral	ADJ
admet-625	359	7	controlled	control	VERB
admet-625	359	8	-	-	PUNCT
admet-625	359	9	release	release	NOUN
admet-625	359	10	delivery	delivery	NOUN
admet-625	359	11	system	system	NOUN
admet-625	359	12	for	for	ADP
admet-625	359	13	melatonin	melatonin	NOUN
admet-625	359	14	.	.	PUNCT
admet-625	360	1	drug	drug	PROPN
admet-625	360	2	dev	dev	PROPN
admet-625	360	3	.	.	PUNCT
admet-625	361	1	ind	ind	PROPN
admet-625	361	2	.	.	PUNCT
admet-625	362	1	pharm	pharm	PROPN
admet-625	362	2	.	.	PUNCT
admet-625	363	1	22	22	NUM
admet-625	363	2	(	(	PUNCT
admet-625	363	3	1996	1996	NUM
admet-625	363	4	)	)	PUNCT
admet-625	363	5	269	269	NUM
admet-625	363	6	-	-	SYM
admet-625	363	7	274	274	NUM
admet-625	363	8	.	.	PUNCT
admet-625	364	1	[	[	X
admet-625	364	2	37	37	NUM
admet-625	364	3	]	]	X
admet-625	364	4	l.p	l.p	PROPN
admet-625	364	5	.	.	PROPN
admet-625	364	6	andersen	andersen	PROPN
admet-625	364	7	,	,	PUNCT
admet-625	364	8	m.u	m.u	PROPN
admet-625	364	9	.	.	PROPN
admet-625	364	10	werner	werner	PROPN
admet-625	364	11	,	,	PUNCT
admet-625	364	12	m.m	m.m	PROPN
admet-625	364	13	.	.	PROPN
admet-625	364	14	rosenkilde	rosenkilde	PROPN
admet-625	364	15	,	,	PUNCT
admet-625	364	16	a.q	a.q	PROPN
admet-625	364	17	.	.	PROPN
admet-625	364	18	fenger	fenger	PROPN
admet-625	364	19	,	,	PUNCT
admet-625	364	20	m.c	m.c	PROPN
admet-625	364	21	.	.	PROPN
admet-625	364	22	petersen	petersen	PROPN
admet-625	364	23	,	,	PUNCT
admet-625	364	24	j.	j.	PROPN
admet-625	364	25	rosenberg	rosenberg	PROPN
admet-625	364	26	,	,	PUNCT
admet-625	364	27	i.	i.	PROPN
admet-625	364	28	gogenur	gogenur	PROPN
admet-625	364	29	.	.	PUNCT
admet-625	365	1	pharmacokinetics	pharmacokinetic	NOUN
admet-625	365	2	of	of	ADP
admet-625	365	3	high	high	ADV
admet-625	365	4	-	-	PUNCT
admet-625	365	5	dose	dose	NOUN
admet-625	365	6	intravenous	intravenous	ADJ
admet-625	365	7	melatonin	melatonin	NOUN
admet-625	365	8	in	in	ADP
admet-625	365	9	humans	human	NOUN
admet-625	365	10	.	.	PUNCT
admet-625	366	1	j.	j.	PROPN
admet-625	366	2	clin	clin	PROPN
admet-625	366	3	.	.	PUNCT
admet-625	367	1	pharmacol	pharmacol	PROPN
admet-625	367	2	.	.	PUNCT
admet-625	368	1	56	56	NUM
admet-625	368	2	(	(	PUNCT
admet-625	368	3	2016	2016	NUM
admet-625	368	4	)	)	PUNCT
admet-625	368	5	324	324	NUM
admet-625	368	6	-	-	SYM
admet-625	368	7	329	329	NUM
admet-625	368	8	.	.	PUNCT
admet-625	369	1	[	[	X
admet-625	369	2	38	38	NUM
admet-625	369	3	]	]	PUNCT
admet-625	369	4	c.	c.	PROPN
admet-625	369	5	mallo	mallo	PROPN
admet-625	369	6	,	,	PUNCT
admet-625	369	7	r.	r.	PROPN
admet-625	369	8	zaidan	zaidan	PROPN
admet-625	369	9	,	,	PUNCT
admet-625	369	10	g.	g.	PROPN
admet-625	369	11	galy	galy	PROPN
admet-625	369	12	,	,	PUNCT
admet-625	369	13	e.	e.	PROPN
admet-625	369	14	vermeulen	vermeulen	PROPN
admet-625	369	15	,	,	PUNCT
admet-625	369	16	j.	j.	PROPN
admet-625	369	17	brun	brun	PROPN
admet-625	369	18	,	,	PUNCT
admet-625	369	19	g.	g.	PROPN
admet-625	369	20	chazot	chazot	PROPN
admet-625	369	21	,	,	PUNCT
admet-625	369	22	b.	b.	PROPN
admet-625	369	23	claustrat	claustrat	PROPN
admet-625	369	24	.	.	PUNCT
admet-625	370	1	pharmacokinetics	pharmacokinetic	NOUN
admet-625	370	2	of	of	ADP
admet-625	370	3	melatonin	melatonin	NOUN
admet-625	370	4	in	in	ADP
admet-625	370	5	man	man	NOUN
admet-625	370	6	after	after	ADP
admet-625	370	7	intravenous	intravenous	ADJ
admet-625	370	8	infusion	infusion	NOUN
admet-625	370	9	and	and	CCONJ
admet-625	370	10	bolus	bolus	ADJ
admet-625	370	11	injection	injection	NOUN
admet-625	370	12	.	.	PUNCT
admet-625	371	1	eur	eur	PROPN
admet-625	371	2	.	.	PUNCT
admet-625	372	1	j.	j.	PROPN
admet-625	372	2	clin	clin	PROPN
admet-625	372	3	.	.	PUNCT
admet-625	373	1	pharmacol	pharmacol	PROPN
admet-625	373	2	.	.	PUNCT
admet-625	374	1	38	38	NUM
admet-625	374	2	(	(	PUNCT
admet-625	374	3	1990	1990	NUM
admet-625	374	4	)	)	PUNCT
admet-625	374	5	297	297	NUM
admet-625	374	6	-	-	SYM
admet-625	374	7	301	301	NUM
admet-625	374	8	.	.	PUNCT
admet-625	375	1	[	[	X
admet-625	375	2	39	39	NUM
admet-625	375	3	]	]	X
admet-625	375	4	j.b	j.b	PROPN
admet-625	375	5	.	.	PROPN
admet-625	375	6	fourtillan	fourtillan	PROPN
admet-625	375	7	,	,	PUNCT
admet-625	375	8	a.m.	a.m.	PROPN
admet-625	375	9	brisson	brisson	PROPN
admet-625	375	10	,	,	PUNCT
admet-625	375	11	p.	p.	PROPN
admet-625	375	12	gobin	gobin	PROPN
admet-625	375	13	,	,	PUNCT
admet-625	375	14	i.	i.	PROPN
admet-625	375	15	ingrand	ingrand	PROPN
admet-625	375	16	,	,	PUNCT
admet-625	375	17	j.p	j.p	PROPN
admet-625	375	18	.	.	PROPN
admet-625	375	19	decourt	decourt	PROPN
admet-625	375	20	,	,	PUNCT
admet-625	375	21	j.	j.	PROPN
admet-625	375	22	girault	girault	PROPN
admet-625	375	23	.	.	PUNCT
admet-625	376	1	bioavailability	bioavailability	NOUN
admet-625	376	2	of	of	ADP
admet-625	376	3	melatonin	melatonin	NOUN
admet-625	376	4	in	in	ADP
admet-625	376	5	humans	human	NOUN
admet-625	376	6	after	after	ADP
admet-625	376	7	day	day	NOUN
admet-625	376	8	-	-	PUNCT
admet-625	376	9	time	time	NOUN
admet-625	376	10	administration	administration	NOUN
admet-625	376	11	of	of	ADP
admet-625	376	12	d(7	d(7	PROPN
admet-625	376	13	)	)	PUNCT
admet-625	376	14	melatonin	melatonin	NOUN
admet-625	376	15	.	.	PUNCT
admet-625	377	1	biopharm	biopharm	NOUN
admet-625	377	2	.	.	PUNCT
admet-625	378	1	drug	drug	PROPN
admet-625	378	2	dispos	dispos	PROPN
admet-625	378	3	.	.	PUNCT
admet-625	379	1	21	21	NUM
admet-625	379	2	(	(	PUNCT
admet-625	379	3	2000	2000	NUM
admet-625	379	4	)	)	PUNCT
admet-625	379	5	1522	1522	NUM
admet-625	379	6	.	.	PUNCT
admet-625	380	1	[	[	X
admet-625	380	2	40	40	NUM
admet-625	380	3	]	]	PUNCT
admet-625	380	4	m.	m.	NOUN
admet-625	380	5	aldhous	aldhous	PROPN
admet-625	380	6	,	,	PUNCT
admet-625	380	7	c.	c.	PROPN
admet-625	380	8	franey	franey	NOUN
admet-625	380	9	,	,	PUNCT
admet-625	380	10	j.	j.	PROPN
admet-625	380	11	wright	wright	PROPN
admet-625	380	12	,	,	PUNCT
admet-625	380	13	j.	j.	PROPN
admet-625	380	14	arendt	arendt	PROPN
admet-625	380	15	.	.	PUNCT
admet-625	381	1	plasma	plasma	NOUN
admet-625	381	2	concentrations	concentration	NOUN
admet-625	381	3	of	of	ADP
admet-625	381	4	melatonin	melatonin	NOUN
admet-625	381	5	in	in	ADP
admet-625	381	6	man	man	NOUN
admet-625	381	7	following	follow	VERB
admet-625	381	8	oral	oral	ADJ
admet-625	381	9	absorption	absorption	NOUN
admet-625	381	10	of	of	ADP
admet-625	381	11	different	different	ADJ
admet-625	381	12	preparations	preparation	NOUN
admet-625	381	13	.	.	PUNCT
admet-625	382	1	br	br	PROPN
admet-625	382	2	.	.	PUNCT
admet-625	383	1	j.	j.	PROPN
admet-625	383	2	clin	clin	PROPN
admet-625	383	3	.	.	PUNCT
admet-625	384	1	pharmacol	pharmacol	PROPN
admet-625	384	2	.	.	PROPN
admet-625	385	1	19	19	NUM
admet-625	385	2	(	(	PUNCT
admet-625	385	3	1985	1985	NUM
admet-625	385	4	)	)	PUNCT
admet-625	385	5	517	517	NUM
admet-625	385	6	-	-	SYM
admet-625	385	7	521	521	NUM
admet-625	385	8	.	.	PUNCT
admet-625	386	1	[	[	X
admet-625	386	2	41	41	NUM
admet-625	386	3	]	]	X
admet-625	386	4	d.	d.	PROPN
admet-625	386	5	aeschbach	aeschbach	PROPN
admet-625	386	6	,	,	PUNCT
admet-625	386	7	b.j	b.j	PROPN
admet-625	386	8	.	.	PROPN
admet-625	386	9	lockyer	lockyer	PROPN
admet-625	386	10	,	,	PUNCT
admet-625	386	11	d.j	d.j	PROPN
admet-625	386	12	.	.	PROPN
admet-625	386	13	dijk	dijk	PROPN
admet-625	386	14	,	,	PUNCT
admet-625	386	15	s.w	s.w	PROPN
admet-625	386	16	.	.	PROPN
admet-625	386	17	lockley	lockley	PROPN
admet-625	386	18	,	,	PUNCT
admet-625	386	19	e.s	e.s	PROPN
admet-625	386	20	.	.	PROPN
admet-625	386	21	nuwayser	nuwayser	PROPN
admet-625	386	22	,	,	PUNCT
admet-625	386	23	l.d	l.d	PROPN
admet-625	386	24	.	.	PROPN
admet-625	386	25	nichols	nichols	PROPN
admet-625	386	26	,	,	PUNCT
admet-625	386	27	c.a	c.a	PROPN
admet-625	386	28	.	.	PROPN
admet-625	386	29	czeisler	czeisler	PROPN
admet-625	386	30	.	.	PUNCT
admet-625	387	1	use	use	NOUN
admet-625	387	2	of	of	ADP
admet-625	387	3	transdermal	transdermal	ADJ
admet-625	387	4	melatonin	melatonin	NOUN
admet-625	387	5	delivery	delivery	NOUN
admet-625	387	6	to	to	PART
admet-625	387	7	improve	improve	VERB
admet-625	387	8	sleep	sleep	NOUN
admet-625	387	9	maintenance	maintenance	NOUN
admet-625	387	10	during	during	ADP
admet-625	387	11	daytime	daytime	NOUN
admet-625	387	12	.	.	PUNCT
admet-625	388	1	clin	clin	PROPN
admet-625	388	2	.	.	PUNCT
admet-625	389	1	pharmacol	pharmacol	PROPN
admet-625	389	2	.	.	PUNCT
admet-625	390	1	ther	ther	PROPN
admet-625	390	2	.	.	PUNCT
admet-625	391	1	86	86	NUM
admet-625	391	2	(	(	PUNCT
admet-625	391	3	2009	2009	NUM
admet-625	391	4	)	)	PUNCT
admet-625	391	5	378	378	NUM
admet-625	391	6	-	-	SYM
admet-625	391	7	382	382	NUM
admet-625	391	8	.	.	PUNCT
admet-625	392	1	admet	admet	PROPN
admet-625	392	2	&	&	CCONJ
admet-625	392	3	dmpk	dmpk	PROPN
admet-625	392	4	7(1	7(1	PROPN
admet-625	392	5	)	)	PUNCT
admet-625	392	6	(	(	PUNCT
admet-625	392	7	2019	2019	NUM
admet-625	392	8	)	)	PUNCT
admet-625	392	9	44	44	NUM
admet-625	392	10	-	-	SYM
admet-625	392	11	59	59	NUM
admet-625	392	12	pbpk	pbpk	ADJ
admet-625	392	13	simulation	simulation	NOUN
admet-625	392	14	in	in	ADP
admet-625	392	15	pharmacotherapy	pharmacotherapy	NOUN
admet-625	392	16	doi	doi	NOUN
admet-625	392	17	:	:	PUNCT
admet-625	392	18	10.5599	10.5599	NUM
admet-625	392	19	/	/	SYM
admet-625	392	20	admet.625	admet.625	NUM
admet-625	392	21	59	59	NUM
admet-625	392	22	appendix	appendix	NOUN
admet-625	392	23	table	table	NOUN
admet-625	392	24	a.	a.	NOUN
admet-625	392	25	–	–	PUNCT
admet-625	392	26	key	key	ADJ
admet-625	392	27	model	model	NOUN
admet-625	392	28	parameters	parameter	NOUN
admet-625	392	29	in	in	ADP
admet-625	392	30	case	case	NOUN
admet-625	392	31	of	of	ADP
admet-625	392	32	the	the	DET
admet-625	392	33	iv	iv	NUM
admet-625	392	34	route	route	NOUN
admet-625	392	35	,	,	PUNCT
admet-625	392	36	correlated	correlate	VERB
admet-625	392	37	by	by	ADP
admet-625	392	38	90	90	NUM
admet-625	392	39	%	%	NOUN
admet-625	392	40	confidence	confidence	NOUN
admet-625	392	41	intervals	interval	NOUN
admet-625	392	42	.	.	PUNCT
admet-625	393	1	parameters	parameter	NOUN
admet-625	393	2	description	description	NOUN
admet-625	393	3	regressed	regress	VERB
admet-625	393	4	values	value	NOUN
admet-625	393	5	90	90	NUM
admet-625	393	6	%	%	NOUN
admet-625	393	7	𝑪𝑰𝒍𝒃	𝑪𝑰𝒍𝒃	PROPN
admet-625	393	8	90	90	NUM
admet-625	393	9	%	%	NOUN
admet-625	393	10	𝑪𝑰𝒖𝒃	𝑪𝑰𝒖𝒃	PROPN
admet-625	393	11	𝒌𝑻−𝑷	𝒌𝑻−𝑷	PROPN
admet-625	393	12	[	[	PUNCT
admet-625	393	13	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	393	14	]	]	PUNCT
admet-625	393	15	plasma	plasma	NOUN
admet-625	393	16	-	-	PUNCT
admet-625	393	17	poor	poor	ADJ
admet-625	393	18	tissues	tissue	NOUN
admet-625	393	19	transfer	transfer	NOUN
admet-625	393	20	coefficient	coefficient	NOUN
admet-625	393	21	0.3955	0.3955	NUM
admet-625	393	22	0.373	0.373	NUM
admet-625	393	23	0.418	0.418	NUM
admet-625	393	24	𝒌𝑷−𝑻	𝒌𝑷−𝑻	PROPN
admet-625	393	25	[	[	PUNCT
admet-625	393	26	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	393	27	]	]	SYM
admet-625	393	28	poor	poor	ADJ
admet-625	393	29	-	-	PUNCT
admet-625	393	30	tissues	tissue	NOUN
admet-625	393	31	plasma	plasma	NOUN
admet-625	393	32	transfer	transfer	NOUN
admet-625	393	33	coefficient	coefficient	NOUN
admet-625	393	34	0.8	0.8	NUM
admet-625	393	35	0.774	0.774	NUM
admet-625	393	36	0.826	0.826	NUM
admet-625	393	37	𝒌𝑯𝑷−𝑷	𝒌𝑯𝑷−𝑷	PROPN
admet-625	393	38	[	[	PUNCT
admet-625	393	39	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	393	40	]	]	X
admet-625	393	41	highly	highly	ADV
admet-625	393	42	perfused	perfused	ADJ
admet-625	393	43	organs	organ	NOUN
admet-625	393	44	plasma	plasma	NOUN
admet-625	393	45	transfer	transfer	NOUN
admet-625	393	46	coefficient	coefficient	NOUN
admet-625	393	47	0.047	0.047	NUM
admet-625	393	48	0.045	0.045	NUM
admet-625	393	49	0.05	0.05	NUM
admet-625	393	50	𝒌𝑷−𝑯𝑷	𝒌𝑷−𝑯𝑷	NUM
admet-625	393	51	[	[	PUNCT
admet-625	393	52	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	393	53	]	]	PUNCT
admet-625	393	54	plasma	plasma	NOUN
admet-625	393	55	-	-	PUNCT
admet-625	393	56	highly	highly	ADV
admet-625	393	57	perfused	perfused	ADJ
admet-625	393	58	organs	organ	NOUN
admet-625	393	59	transfer	transfer	VERB
admet-625	393	60	coefficient	coefficient	NOUN
admet-625	393	61	1.48	1.48	NUM
admet-625	393	62	1.416	1.416	NUM
admet-625	393	63	1.544	1.544	NUM
admet-625	393	64	table	table	NOUN
admet-625	393	65	b.	b.	NOUN
admet-625	393	66	–	–	PUNCT
admet-625	393	67	key	key	ADJ
admet-625	393	68	model	model	NOUN
admet-625	393	69	parameters	parameter	NOUN
admet-625	393	70	in	in	ADP
admet-625	393	71	case	case	NOUN
admet-625	393	72	of	of	ADP
admet-625	393	73	the	the	DET
admet-625	393	74	po	po	PROPN
admet-625	393	75	route	route	PROPN
admet-625	393	76	,	,	PUNCT
admet-625	393	77	correlated	correlate	VERB
admet-625	393	78	by	by	ADP
admet-625	393	79	90	90	NUM
admet-625	393	80	%	%	NOUN
admet-625	393	81	confidence	confidence	NOUN
admet-625	393	82	intervals	interval	NOUN
admet-625	393	83	.	.	PUNCT
admet-625	394	1	parameters	parameter	NOUN
admet-625	394	2	description	description	NOUN
admet-625	394	3	regressed	regress	VERB
admet-625	394	4	values	value	NOUN
admet-625	394	5	90	90	NUM
admet-625	394	6	%	%	NOUN
admet-625	394	7	𝑪𝑰𝒍𝒃	𝑪𝑰𝒍𝒃	PROPN
admet-625	394	8	90	90	NUM
admet-625	394	9	%	%	NOUN
admet-625	394	10	𝑪𝑰𝒖𝒃	𝑪𝑰𝒖𝒃	PROPN
admet-625	394	11	𝒌𝑨,𝑺𝑰𝑳	𝒌𝑨,𝑺𝑰𝑳	NUM
admet-625	394	12	[	[	PUNCT
admet-625	394	13	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	394	14	]	]	PUNCT
admet-625	394	15	𝑆𝐼𝐿	𝑆𝐼𝐿	PROPN
admet-625	394	16	absorption	absorption	NOUN
admet-625	394	17	constant	constant	ADJ
admet-625	394	18	2.205	2.205	NUM
admet-625	394	19	0.245	0.245	NUM
admet-625	394	20	5.655	5.655	NUM
admet-625	394	21	𝒌𝑪𝑨,𝑺𝑰𝑳	𝒌𝑪𝑨,𝑺𝑰𝑳	NOUN
admet-625	394	22	[	[	PUNCT
admet-625	394	23	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	394	24	]	]	PUNCT
admet-625	394	25	𝑆𝐼𝐿	𝑆𝐼𝐿	PROPN
admet-625	394	26	counter	counter	NOUN
admet-625	394	27	-	-	NOUN
admet-625	394	28	diffusion	diffusion	NOUN
admet-625	394	29	constant	constant	ADJ
admet-625	394	30	2.920	2.920	NUM
admet-625	394	31	0.158	0.158	NUM
admet-625	394	32	5.683	5.683	NUM
admet-625	394	33	𝒌𝑨,𝑳𝑰𝑳	𝒌𝑨,𝑳𝑰𝑳	NOUN
admet-625	394	34	[	[	PUNCT
admet-625	394	35	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	394	36	]	]	X
admet-625	394	37	𝐿𝐼𝐿	𝐿𝐼𝐿	NOUN
admet-625	394	38	absorption	absorption	NOUN
admet-625	394	39	constant	constant	ADJ
admet-625	394	40	0.167	0.167	NUM
admet-625	394	41	0.003	0.003	NUM
admet-625	394	42	0.337	0.337	NUM
admet-625	394	43	𝒌𝑪𝑨,𝑳𝑰𝑳	𝒌𝑪𝑨,𝑳𝑰𝑳	PROPN
admet-625	394	44	[	[	PUNCT
admet-625	394	45	𝒎𝒊𝒏−𝟏	𝒎𝒊𝒏−𝟏	PROPN
admet-625	394	46	]	]	X
admet-625	394	47	𝐿𝐼𝐿	𝐿𝐼𝐿	PROPN
admet-625	394	48	counter	counter	NOUN
admet-625	394	49	-	-	NOUN
admet-625	394	50	diffusion	diffusion	NOUN
admet-625	394	51	constant	constant	ADJ
admet-625	394	52	0.455	0.455	NUM
admet-625	394	53	0.059	0.059	NUM
admet-625	394	54	0.851	0.851	NUM
admet-625	394	55	𝑬𝒇𝒇𝑯	𝑬𝒇𝒇𝑯	NOUN
admet-625	394	56	[	[	PUNCT
admet-625	394	57	−	−	NOUN
admet-625	394	58	]	]	X
admet-625	394	59	hepatic	hepatic	ADJ
admet-625	394	60	metabolism	metabolism	NOUN
admet-625	394	61	efficiency	efficiency	NOUN
admet-625	394	62	0.467	0.467	NUM
admet-625	394	63	0.235	0.235	NUM
admet-625	394	64	0.699	0.699	NUM
admet-625	394	65	𝑬𝒇𝒇𝑲	𝑬𝒇𝒇𝑲	ADJ
admet-625	394	66	[	[	PUNCT
admet-625	394	67	−	−	NOUN
admet-625	394	68	]	]	PUNCT
admet-625	394	69	kidneys	kidney	NOUN
admet-625	394	70	excretion	excretion	NOUN
admet-625	394	71	efficiency	efficiency	NOUN
admet-625	394	72	0.053	0.053	NUM
admet-625	394	73	0	0	NUM
admet-625	394	74	.	.	PUNCT
admet-625	395	1	007	007	NUM
admet-625	395	2	0.113	0.113	NUM
admet-625	395	3	table	table	NOUN
admet-625	395	4	c.	c.	NOUN
admet-625	395	5	–	–	PUNCT
admet-625	395	6	key	key	ADJ
admet-625	395	7	model	model	NOUN
admet-625	395	8	parameters	parameter	NOUN
admet-625	395	9	in	in	ADP
admet-625	395	10	case	case	NOUN
admet-625	395	11	of	of	ADP
admet-625	395	12	the	the	DET
admet-625	395	13	td	td	NOUN
admet-625	395	14	route	route	NOUN
admet-625	395	15	,	,	PUNCT
admet-625	395	16	correlated	correlate	VERB
admet-625	395	17	by	by	ADP
admet-625	395	18	90	90	NUM
admet-625	395	19	%	%	NOUN
admet-625	395	20	confidence	confidence	NOUN
admet-625	395	21	intervals	interval	NOUN
admet-625	395	22	.	.	PUNCT
admet-625	396	1	parameters	parameter	NOUN
admet-625	396	2	description	description	NOUN
admet-625	396	3	regressed	regress	VERB
admet-625	396	4	values	value	NOUN
admet-625	396	5	90	90	NUM
admet-625	396	6	%	%	NOUN
admet-625	396	7	𝑪𝑰𝒍𝒃	𝑪𝑰𝒍𝒃	PROPN
admet-625	396	8	90	90	NUM
admet-625	396	9	%	%	NOUN
admet-625	396	10	𝑪𝑰𝒖𝒃	𝑪𝑰𝒖𝒃	PROPN
admet-625	396	11	𝕯𝑺𝑪	𝕯𝑺𝑪	PROPN
admet-625	396	12	[	[	PUNCT
admet-625	396	13	𝒄𝒎𝟐	𝒄𝒎𝟐	PROPN
admet-625	396	14	𝒎𝒊𝒏⁄	𝒎𝒊𝒏⁄	NOUN
admet-625	396	15	]	]	PUNCT
admet-625	397	1	𝑆𝐶	𝑆𝐶	PROPN
admet-625	397	2	diffusivity	diffusivity	NOUN
admet-625	397	3	3.352	3.352	NUM
admet-625	397	4	∗	∗	NOUN
admet-625	397	5	10−5	10−5	NUM
admet-625	397	6	1.269	1.269	NUM
admet-625	397	7	∗	∗	NOUN
admet-625	397	8	10−5	10−5	NUM
admet-625	397	9	5.431	5.431	NUM
admet-625	397	10	∗	∗	NOUN
admet-625	397	11	10−5	10−5	NUM
admet-625	397	12	𝕯𝑽𝑬	𝕯𝑽𝑬	PROPN
admet-625	397	13	[	[	PUNCT
admet-625	397	14	𝒄𝒎𝟐	𝒄𝒎𝟐	PROPN
admet-625	397	15	𝒎𝒊𝒏⁄	𝒎𝒊𝒏⁄	NOUN
admet-625	397	16	]	]	PUNCT
admet-625	397	17	𝑉𝐸	𝑉𝐸	PROPN
admet-625	397	18	diffusivity	diffusivity	NOUN
admet-625	397	19	5.943	5.943	NUM
admet-625	397	20	∗	∗	NOUN
admet-625	397	21	10−3	10−3	NUM
admet-625	397	22	2.122	2.122	NUM
admet-625	397	23	∗	∗	NOUN
admet-625	397	24	10−3	10−3	NUM
admet-625	397	25	9.763	9.763	NUM
admet-625	397	26	∗	∗	NOUN
admet-625	397	27	10−3	10−3	NUM
admet-625	397	28	𝕯𝑫𝑬	𝕯𝑫𝑬	PROPN
admet-625	397	29	[	[	PUNCT
admet-625	397	30	𝒄𝒎𝟐	𝒄𝒎𝟐	PROPN
admet-625	397	31	𝒎𝒊𝒏⁄	𝒎𝒊𝒏⁄	NOUN
admet-625	397	32	]	]	PUNCT
admet-625	398	1	𝐷𝐸	𝐷𝐸	PROPN
admet-625	398	2	diffusivity	diffusivity	NOUN
admet-625	398	3	2.776	2.776	NUM
admet-625	398	4	∗	∗	NOUN
admet-625	398	5	10−3	10−3	NUM
admet-625	398	6	1.395	1.395	NUM
admet-625	398	7	∗	∗	NOUN
admet-625	398	8	10−3	10−3	NUM
admet-625	398	9	6.946	6.946	NUM
admet-625	398	10	∗	∗	NOUN
admet-625	398	11	10−3	10−3	NUM
admet-625	398	12	𝒌𝒑𝒂𝒓𝒕𝟏	𝒌𝒑𝒂𝒓𝒕𝟏	NOUN
admet-625	399	1	[	[	X
admet-625	399	2	−	−	X
admet-625	399	3	]	]	X
admet-625	399	4	𝑆𝐶/𝑉𝐸	𝑆𝐶/𝑉𝐸	PUNCT
admet-625	399	5	partition	partition	NOUN
admet-625	399	6	coefficient	coefficient	VERB
admet-625	399	7	1.763	1.763	NUM
admet-625	399	8	1.209	1.209	NUM
admet-625	399	9	2.317	2.317	NUM
admet-625	399	10	©	©	PROPN
admet-625	399	11	2019	2019	NUM
admet-625	399	12	by	by	ADP
admet-625	399	13	the	the	DET
admet-625	399	14	authors	author	NOUN
admet-625	399	15	;	;	PUNCT
admet-625	399	16	licensee	licensee	PROPN
admet-625	399	17	iapc	iapc	PROPN
admet-625	399	18	,	,	PUNCT
admet-625	399	19	zagreb	zagreb	PROPN
admet-625	399	20	,	,	PUNCT
admet-625	399	21	croatia	croatia	PROPN
admet-625	399	22	.	.	PUNCT
admet-625	400	1	this	this	DET
admet-625	400	2	article	article	NOUN
admet-625	400	3	is	be	AUX
admet-625	400	4	an	an	DET
admet-625	400	5	open	open	ADJ
admet-625	400	6	-	-	PUNCT
admet-625	400	7	access	access	NOUN
admet-625	400	8	article	article	NOUN
admet-625	400	9	distributed	distribute	VERB
admet-625	400	10	under	under	ADP
admet-625	400	11	the	the	DET
admet-625	400	12	terms	term	NOUN
admet-625	400	13	and	and	CCONJ
admet-625	400	14	conditions	condition	NOUN
admet-625	400	15	of	of	ADP
admet-625	400	16	the	the	DET
admet-625	400	17	creative	creative	ADJ
admet-625	400	18	commons	common	NOUN
admet-625	400	19	attribution	attribution	NOUN
admet-625	400	20	license	license	NOUN
admet-625	400	21	(	(	PUNCT
admet-625	400	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-625	400	23	)	)	PUNCT
admet-625	400	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN