id	sid	tid	token	lemma	pos
admet-628	1	1	a	a	DET
admet-628	1	2	physiologically	physiologically	ADV
admet-628	1	3	-	-	PUNCT
admet-628	1	4	based	base	VERB
admet-628	1	5	pharmacokinetic	pharmacokinetic	ADJ
admet-628	1	6	model	model	NOUN
admet-628	1	7	of	of	ADP
admet-628	1	8	oseltamivir	oseltamivir	PROPN
admet-628	1	9	phosphate	phosphate	VERB
admet-628	1	10	and	and	CCONJ
admet-628	1	11	its	its	PRON
admet-628	1	12	carboxylate	carboxylate	NOUN
admet-628	1	13	metabolite	metabolite	NOUN
admet-628	1	14	for	for	ADP
admet-628	1	15	rats	rat	NOUN
admet-628	1	16	and	and	CCONJ
admet-628	1	17	humans	human	NOUN
admet-628	1	18	doi	doi	NOUN
admet-628	1	19	:	:	PUNCT
admet-628	1	20	10.5599	10.5599	NUM
admet-628	1	21	/	/	SYM
admet-628	1	22	admet.628	admet.628	PROPN
admet-628	1	23	22	22	NUM
admet-628	1	24	admet	admet	PROPN
admet-628	1	25	&	&	CCONJ
admet-628	1	26	dmpk	dmpk	PROPN
admet-628	1	27	7(1	7(1	PROPN
admet-628	1	28	)	)	PUNCT
admet-628	1	29	(	(	PUNCT
admet-628	1	30	2019	2019	NUM
admet-628	1	31	)	)	PUNCT
admet-628	1	32	22	22	NUM
admet-628	1	33	-	-	SYM
admet-628	1	34	43	43	NUM
admet-628	1	35	;	;	PUNCT
admet-628	1	36	doi	doi	NOUN
admet-628	1	37	:	:	PUNCT
admet-628	1	38	http://dx.doi.org/10.5599/admet.628	http://dx.doi.org/10.5599/admet.628	X
admet-628	1	39	open	open	ADJ
admet-628	1	40	access	access	NOUN
admet-628	1	41	:	:	PUNCT
admet-628	1	42	issn	issn	PROPN
admet-628	1	43	:	:	PUNCT
admet-628	1	44	1848	1848	NUM
admet-628	1	45	-	-	SYM
admet-628	1	46	7718	7718	NUM
admet-628	1	47	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-628	1	48	original	original	ADJ
admet-628	1	49	scientific	scientific	ADJ
admet-628	1	50	paper	paper	NOUN
admet-628	1	51	a	a	DET
admet-628	1	52	physiologically	physiologically	ADV
admet-628	1	53	-	-	PUNCT
admet-628	1	54	based	base	VERB
admet-628	1	55	pharmacokinetic	pharmacokinetic	ADJ
admet-628	1	56	model	model	NOUN
admet-628	1	57	of	of	ADP
admet-628	1	58	oseltamivir	oseltamivir	PROPN
admet-628	1	59	phosphate	phosphate	VERB
admet-628	1	60	and	and	CCONJ
admet-628	1	61	its	its	PRON
admet-628	1	62	carboxylate	carboxylate	NOUN
admet-628	1	63	metabolite	metabolite	NOUN
admet-628	1	64	for	for	ADP
admet-628	1	65	rats	rat	NOUN
admet-628	1	66	and	and	CCONJ
admet-628	1	67	humans	human	NOUN
admet-628	1	68	guanghua	guanghua	PROPN
admet-628	1	69	gao1,3	gao1,3	PROPN
admet-628	1	70	*	*	PROPN
admet-628	1	71	,	,	PUNCT
admet-628	1	72	francis	francis	PROPN
admet-628	1	73	law2	law2	PROPN
admet-628	1	74	,	,	PUNCT
admet-628	1	75	ricky	ricky	PROPN
admet-628	1	76	ngok	ngok	PROPN
admet-628	1	77	shun	shun	PROPN
admet-628	1	78	wong3	wong3	PROPN
admet-628	1	79	,	,	PUNCT
admet-628	1	80	nai	nai	PROPN
admet-628	1	81	ki	ki	PROPN
admet-628	1	82	mak3	mak3	PROPN
admet-628	1	83	,	,	PUNCT
admet-628	1	84	mildred	mildred	PROPN
admet-628	1	85	sze	sze	PROPN
admet-628	1	86	ming	ming	PROPN
admet-628	1	87	yang3	yang3	PROPN
admet-628	1	88	1	1	NUM
admet-628	1	89	center	center	NOUN
admet-628	1	90	for	for	ADP
admet-628	1	91	drug	drug	NOUN
admet-628	1	92	evaluation，china	evaluation，china	NOUN
admet-628	1	93	food	food	NOUN
admet-628	1	94	and	and	CCONJ
admet-628	1	95	drug	drug	NOUN
admet-628	1	96	administration，beijing	administration，beije	VERB
admet-628	1	97	100022，china	100022，china	NUM
admet-628	1	98	;	;	PUNCT
admet-628	1	99	2	2	NUM
admet-628	1	100	department	department	NOUN
admet-628	1	101	of	of	ADP
admet-628	1	102	biological	biological	ADJ
admet-628	1	103	sciences	science	NOUN
admet-628	1	104	,	,	PUNCT
admet-628	1	105	simon	simon	PROPN
admet-628	1	106	fraser	fraser	PROPN
admet-628	1	107	university	university	PROPN
admet-628	1	108	,	,	PUNCT
admet-628	1	109	burnaby	burnaby	PROPN
admet-628	1	110	,	,	PUNCT
admet-628	1	111	b.c	b.c	PROPN
admet-628	1	112	.	.	PROPN
admet-628	1	113	canada	canada	PROPN
admet-628	1	114	v3n	v3n	PROPN
admet-628	1	115	4w8	4w8	PROPN
admet-628	1	116	;	;	PUNCT
admet-628	1	117	3	3	NUM
admet-628	1	118	department	department	NOUN
admet-628	1	119	of	of	ADP
admet-628	1	120	biology	biology	NOUN
admet-628	1	121	,	,	PUNCT
admet-628	1	122	hong	hong	PROPN
admet-628	1	123	kong	kong	PROPN
admet-628	1	124	baptist	baptist	PROPN
admet-628	1	125	university	university	PROPN
admet-628	1	126	,	,	PUNCT
admet-628	1	127	kowloon	kowloon	PROPN
admet-628	1	128	,	,	PUNCT
admet-628	1	129	hong	hong	PROPN
admet-628	1	130	kong	kong	PROPN
admet-628	1	131	.	.	PUNCT
admet-628	2	1	saz	saz	PROPN
admet-628	2	2	.	.	PUNCT
admet-628	3	1	china	china	PROPN
admet-628	3	2	.	.	PUNCT
admet-628	4	1	*	*	PUNCT
admet-628	4	2	corresponding	correspond	VERB
admet-628	4	3	author	author	NOUN
admet-628	4	4	:	:	PUNCT
admet-628	4	5	e	e	NOUN
admet-628	4	6	-	-	NOUN
admet-628	4	7	mail	mail	NOUN
admet-628	4	8	:	:	PUNCT
admet-628	4	9	gaogh@cde.org.cn	gaogh@cde.org.cn	NOUN
admet-628	4	10	;	;	PUNCT
admet-628	4	11	tel	tel	PROPN
admet-628	4	12	.	.	PROPN
admet-628	4	13	:	:	PUNCT
admet-628	4	14	010	010	NUM
admet-628	4	15	-	-	SYM
admet-628	4	16	85243575	85243575	NUM
admet-628	4	17	received	receive	VERB
admet-628	4	18	:	:	PUNCT
admet-628	4	19	october	october	PROPN
admet-628	4	20	30	30	NUM
admet-628	4	21	,	,	PUNCT
admet-628	4	22	2018	2018	NUM
admet-628	4	23	;	;	PUNCT
admet-628	4	24	revised	revise	VERB
admet-628	4	25	:	:	PUNCT
admet-628	4	26	january	january	PROPN
admet-628	4	27	31	31	NUM
admet-628	4	28	,	,	PUNCT
admet-628	4	29	2019	2019	NUM
admet-628	4	30	;	;	PUNCT
admet-628	4	31	published	publish	VERB
admet-628	4	32	:	:	PUNCT
admet-628	4	33	february	february	PROPN
admet-628	4	34	23	23	NUM
admet-628	4	35	,	,	PUNCT
admet-628	4	36	2019	2019	NUM
admet-628	4	37	abstract	abstract	ADJ
admet-628	4	38	oseltamivir	oseltamivir	PROPN
admet-628	4	39	phosphate	phosphate	NOUN
admet-628	4	40	(	(	PUNCT
admet-628	4	41	op	op	NOUN
admet-628	4	42	,	,	PUNCT
admet-628	4	43	tamiflu	tamiflu	PROPN
admet-628	4	44	®	®	PROPN
admet-628	4	45	)	)	PUNCT
admet-628	4	46	is	be	AUX
admet-628	4	47	a	a	DET
admet-628	4	48	widely	widely	ADV
admet-628	4	49	used	use	VERB
admet-628	4	50	prodrug	prodrug	NOUN
admet-628	4	51	for	for	ADP
admet-628	4	52	the	the	DET
admet-628	4	53	treatment	treatment	NOUN
admet-628	4	54	of	of	ADP
admet-628	4	55	influenza	influenza	ADJ
admet-628	4	56	viral	viral	ADJ
admet-628	4	57	infections	infection	NOUN
admet-628	4	58	.	.	PUNCT
admet-628	5	1	orally	orally	ADV
admet-628	5	2	administered	administer	VERB
admet-628	5	3	op	op	NOUN
admet-628	5	4	is	be	AUX
admet-628	5	5	rapidly	rapidly	ADV
admet-628	5	6	hydrolyzed	hydrolyze	VERB
admet-628	5	7	by	by	ADP
admet-628	5	8	the	the	DET
admet-628	5	9	carboxylesterases	carboxylesterase	NOUN
admet-628	5	10	in	in	ADP
admet-628	5	11	animals	animal	NOUN
admet-628	5	12	to	to	ADP
admet-628	5	13	oseltamivir	oseltamivir	PROPN
admet-628	5	14	carboxylate	carboxylate	PROPN
admet-628	5	15	(	(	PUNCT
admet-628	5	16	oc	oc	PROPN
admet-628	5	17	)	)	PUNCT
admet-628	5	18	,	,	PUNCT
admet-628	5	19	a	a	DET
admet-628	5	20	potent	potent	ADJ
admet-628	5	21	influenza	influenza	NOUN
admet-628	5	22	virus	virus	NOUN
admet-628	5	23	neuraminidase	neuraminidase	NOUN
admet-628	5	24	inhibitor	inhibitor	NOUN
admet-628	5	25	.	.	PUNCT
admet-628	6	1	the	the	DET
admet-628	6	2	goals	goal	NOUN
admet-628	6	3	of	of	ADP
admet-628	6	4	this	this	DET
admet-628	6	5	study	study	NOUN
admet-628	6	6	were	be	AUX
admet-628	6	7	to	to	PART
admet-628	6	8	develop	develop	VERB
admet-628	6	9	and	and	CCONJ
admet-628	6	10	validate	validate	VERB
admet-628	6	11	a	a	DET
admet-628	6	12	physiologically	physiologically	ADV
admet-628	6	13	-	-	PUNCT
admet-628	6	14	based	base	VERB
admet-628	6	15	pharmacokinetic	pharmacokinetic	ADJ
admet-628	6	16	(	(	PUNCT
admet-628	6	17	pbpk	pbpk	ADJ
admet-628	6	18	)	)	PUNCT
admet-628	6	19	model	model	NOUN
admet-628	6	20	of	of	ADP
admet-628	6	21	op	op	NOUN
admet-628	6	22	/	/	SYM
admet-628	6	23	oc	oc	NOUN
admet-628	6	24	in	in	ADP
admet-628	6	25	rats	rat	NOUN
admet-628	6	26	and	and	CCONJ
admet-628	6	27	humans	human	NOUN
admet-628	6	28	,	,	PUNCT
admet-628	6	29	and	and	CCONJ
admet-628	6	30	to	to	PART
admet-628	6	31	predict	predict	VERB
admet-628	6	32	the	the	DET
admet-628	6	33	internal	internal	ADJ
admet-628	6	34	tissue	tissue	NOUN
admet-628	6	35	doses	dose	NOUN
admet-628	6	36	for	for	ADP
admet-628	6	37	op	op	NOUN
admet-628	6	38	and	and	CCONJ
admet-628	6	39	oc	oc	NOUN
admet-628	6	40	in	in	ADP
admet-628	6	41	humans	human	NOUN
admet-628	6	42	after	after	ADP
admet-628	6	43	receiving	receive	VERB
admet-628	6	44	op	op	NOUN
admet-628	6	45	orally	orally	ADV
admet-628	6	46	.	.	PUNCT
admet-628	7	1	to	to	ADP
admet-628	7	2	this	this	DET
admet-628	7	3	end	end	NOUN
admet-628	7	4	,	,	PUNCT
admet-628	7	5	a	a	DET
admet-628	7	6	pbpk	pbpk	ADJ
admet-628	7	7	model	model	NOUN
admet-628	7	8	of	of	ADP
admet-628	7	9	op	op	NOUN
admet-628	7	10	/	/	SYM
admet-628	7	11	oc	oc	NOUN
admet-628	7	12	was	be	AUX
admet-628	7	13	first	first	ADV
admet-628	7	14	developed	develop	VERB
admet-628	7	15	in	in	ADP
admet-628	7	16	the	the	DET
admet-628	7	17	rat	rat	NOUN
admet-628	7	18	,	,	PUNCT
admet-628	7	19	which	which	PRON
admet-628	7	20	was	be	AUX
admet-628	7	21	then	then	ADV
admet-628	7	22	scaled	scale	VERB
admet-628	7	23	up	up	ADP
admet-628	7	24	to	to	ADP
admet-628	7	25	humans	human	NOUN
admet-628	7	26	by	by	ADP
admet-628	7	27	replacing	replace	VERB
admet-628	7	28	the	the	DET
admet-628	7	29	physiological	physiological	ADJ
admet-628	7	30	and	and	CCONJ
admet-628	7	31	biochemical	biochemical	ADJ
admet-628	7	32	parameters	parameter	NOUN
admet-628	7	33	with	with	ADP
admet-628	7	34	human	human	NOUN
admet-628	7	35	-	-	PUNCT
admet-628	7	36	specific	specific	ADJ
admet-628	7	37	values	value	NOUN
admet-628	7	38	.	.	PUNCT
admet-628	8	1	the	the	DET
admet-628	8	2	proposed	propose	VERB
admet-628	8	3	pbpk	pbpk	PROPN
admet-628	8	4	model	model	NOUN
admet-628	8	5	consisted	consist	VERB
admet-628	8	6	of	of	ADP
admet-628	8	7	an	an	DET
admet-628	8	8	op	op	NOUN
admet-628	8	9	and	and	CCONJ
admet-628	8	10	an	an	DET
admet-628	8	11	oc	oc	NOUN
admet-628	8	12	sub	sub	NOUN
admet-628	8	13	-	-	NOUN
admet-628	8	14	models	model	NOUN
admet-628	8	15	each	each	PRON
admet-628	8	16	containing	contain	VERB
admet-628	8	17	nine	nine	NUM
admet-628	8	18	first	first	ADJ
admet-628	8	19	-	-	PUNCT
admet-628	8	20	order	order	NOUN
admet-628	8	21	,	,	PUNCT
admet-628	8	22	flow	flow	NOUN
admet-628	8	23	-	-	PUNCT
admet-628	8	24	limited	limit	VERB
admet-628	8	25	tissue	tissue	NOUN
admet-628	8	26	/	/	SYM
admet-628	8	27	organ	organ	NOUN
admet-628	8	28	compartments	compartment	NOUN
admet-628	8	29	.	.	PUNCT
admet-628	9	1	op	op	NOUN
admet-628	9	2	metabolism	metabolism	NOUN
admet-628	9	3	to	to	ADP
admet-628	9	4	oc	oc	PROPN
admet-628	9	5	was	be	AUX
admet-628	9	6	assumed	assume	VERB
admet-628	9	7	to	to	PART
admet-628	9	8	carry	carry	VERB
admet-628	9	9	out	out	ADP
admet-628	9	10	mainly	mainly	ADV
admet-628	9	11	by	by	ADP
admet-628	9	12	hepatic	hepatic	ADJ
admet-628	9	13	carboxylesterases	carboxylesterase	NOUN
admet-628	9	14	although	although	SCONJ
admet-628	9	15	extrahepatic	extrahepatic	ADJ
admet-628	9	16	metabolism	metabolism	NOUN
admet-628	9	17	also	also	ADV
admet-628	9	18	occurred	occur	VERB
admet-628	9	19	especially	especially	ADV
admet-628	9	20	in	in	ADP
admet-628	9	21	the	the	DET
admet-628	9	22	plasma	plasma	NOUN
admet-628	9	23	.	.	PUNCT
admet-628	10	1	the	the	DET
admet-628	10	2	pbpk	pbpk	PROPN
admet-628	10	3	model	model	NOUN
admet-628	10	4	was	be	AUX
admet-628	10	5	developed	develop	VERB
admet-628	10	6	and	and	CCONJ
admet-628	10	7	validated	validate	VERB
admet-628	10	8	by	by	ADP
admet-628	10	9	experimental	experimental	ADJ
admet-628	10	10	data	datum	NOUN
admet-628	10	11	from	from	ADP
admet-628	10	12	our	our	PRON
admet-628	10	13	laboratories	laboratory	NOUN
admet-628	10	14	and	and	CCONJ
admet-628	10	15	from	from	ADP
admet-628	10	16	the	the	DET
admet-628	10	17	literature	literature	NOUN
admet-628	10	18	.	.	PUNCT
admet-628	11	1	the	the	DET
admet-628	11	2	proposed	propose	VERB
admet-628	11	3	pbpk	pbpk	PROPN
admet-628	11	4	model	model	NOUN
admet-628	11	5	accurately	accurately	ADV
admet-628	11	6	predicted	predict	VERB
admet-628	11	7	the	the	DET
admet-628	11	8	pharmacokinetic	pharmacokinetic	ADJ
admet-628	11	9	behavior	behavior	NOUN
admet-628	11	10	of	of	ADP
admet-628	11	11	op	op	NOUN
admet-628	11	12	and	and	CCONJ
admet-628	11	13	oc	oc	X
admet-628	11	14	in	in	ADP
admet-628	11	15	humans	human	NOUN
admet-628	11	16	and	and	CCONJ
admet-628	11	17	rats	rat	NOUN
admet-628	11	18	after	after	ADP
admet-628	11	19	receiving	receive	VERB
admet-628	11	20	a	a	DET
admet-628	11	21	single	single	ADJ
admet-628	11	22	or	or	CCONJ
admet-628	11	23	multiple	multiple	ADJ
admet-628	11	24	doses	dose	NOUN
admet-628	11	25	of	of	ADP
admet-628	11	26	op	op	NOUN
admet-628	11	27	orally	orally	ADV
admet-628	11	28	or	or	CCONJ
admet-628	11	29	an	an	DET
admet-628	11	30	oc	oc	NOUN
admet-628	11	31	dose	dose	NOUN
admet-628	11	32	i.v	i.v	PROPN
admet-628	11	33	.	.	PUNCT
admet-628	12	1	the	the	DET
admet-628	12	2	pbpk	pbpk	PROPN
admet-628	12	3	model	model	NOUN
admet-628	12	4	was	be	AUX
admet-628	12	5	used	use	VERB
admet-628	12	6	to	to	PART
admet-628	12	7	predict	predict	VERB
admet-628	12	8	the	the	DET
admet-628	12	9	internal	internal	ADJ
admet-628	12	10	tissue	tissue	NOUN
admet-628	12	11	doses	dose	NOUN
admet-628	12	12	of	of	ADP
admet-628	12	13	op	op	NOUN
admet-628	12	14	and	and	CCONJ
admet-628	12	15	oc	oc	NOUN
admet-628	12	16	in	in	ADP
admet-628	12	17	a	a	DET
admet-628	12	18	hypothetical	hypothetical	ADJ
admet-628	12	19	human	human	NOUN
admet-628	12	20	after	after	ADP
admet-628	12	21	receiving	receive	VERB
admet-628	12	22	the	the	DET
admet-628	12	23	recommended	recommend	VERB
admet-628	12	24	dose	dose	NOUN
admet-628	12	25	of	of	ADP
admet-628	12	26	75	75	NUM
admet-628	12	27	mg	mg	PROPN
admet-628	12	28	/	/	SYM
admet-628	12	29	kg	kg	NOUN
admet-628	12	30	op	op	NOUN
admet-628	12	31	b.i.d	b.i.d	PROPN
admet-628	12	32	.	.	PUNCT
admet-628	13	1	for	for	ADP
admet-628	13	2	6	6	NUM
admet-628	13	3	days	day	NOUN
admet-628	13	4	.	.	PUNCT
admet-628	14	1	steady	steady	ADJ
admet-628	14	2	-	-	PUNCT
admet-628	14	3	state	state	NOUN
admet-628	14	4	oc	oc	NOUN
admet-628	14	5	concentrations	concentration	NOUN
admet-628	14	6	in	in	ADP
admet-628	14	7	the	the	DET
admet-628	14	8	plasma	plasma	NOUN
admet-628	14	9	and	and	CCONJ
admet-628	14	10	major	major	ADJ
admet-628	14	11	organs	organ	NOUN
admet-628	14	12	such	such	ADJ
admet-628	14	13	as	as	ADP
admet-628	14	14	the	the	DET
admet-628	14	15	lung	lung	NOUN
admet-628	14	16	and	and	CCONJ
admet-628	14	17	the	the	DET
admet-628	14	18	brain	brain	NOUN
admet-628	14	19	were	be	AUX
admet-628	14	20	higher	high	ADJ
admet-628	14	21	than	than	ADP
admet-628	14	22	the	the	DET
admet-628	14	23	minimum	minimum	NOUN
admet-628	14	24	in	in	ADP
admet-628	14	25	vitro	vitro	X
admet-628	14	26	ic50	ic50	PROPN
admet-628	14	27	reported	report	VERB
admet-628	14	28	for	for	ADP
admet-628	14	29	h1n1	h1n1	NOUN
admet-628	14	30	influenza	influenza	NOUN
admet-628	14	31	virus	virus	NOUN
admet-628	14	32	neuraminidase	neuraminidase	NOUN
admet-628	14	33	,	,	PUNCT
admet-628	14	34	confirming	confirm	VERB
admet-628	14	35	op	op	NOUN
admet-628	14	36	is	be	AUX
admet-628	14	37	an	an	DET
admet-628	14	38	effective	effective	ADJ
admet-628	14	39	,	,	PUNCT
admet-628	14	40	anti	anti	ADJ
admet-628	14	41	-	-	ADJ
admet-628	14	42	viral	viral	ADJ
admet-628	14	43	agent	agent	NOUN
admet-628	14	44	.	.	PUNCT
admet-628	15	1	op	op	NOUN
admet-628	15	2	side	side	NOUN
admet-628	15	3	-	-	PUNCT
admet-628	15	4	effects	effect	NOUN
admet-628	15	5	in	in	ADP
admet-628	15	6	the	the	DET
admet-628	15	7	gastrointestinal	gastrointestinal	ADJ
admet-628	15	8	tract	tract	NOUN
admet-628	15	9	and	and	CCONJ
admet-628	15	10	brain	brain	NOUN
admet-628	15	11	of	of	ADP
admet-628	15	12	humans	human	NOUN
admet-628	15	13	were	be	AUX
admet-628	15	14	explainable	explainable	ADJ
admet-628	15	15	by	by	ADP
admet-628	15	16	the	the	DET
admet-628	15	17	tissue	tissue	NOUN
admet-628	15	18	doses	dose	NOUN
admet-628	15	19	found	find	VERB
admet-628	15	20	in	in	ADP
admet-628	15	21	these	these	DET
admet-628	15	22	organs	organ	NOUN
admet-628	15	23	.	.	PUNCT
admet-628	16	1	the	the	DET
admet-628	16	2	pbpk	pbpk	PROPN
admet-628	16	3	model	model	NOUN
admet-628	16	4	provides	provide	VERB
admet-628	16	5	a	a	DET
admet-628	16	6	quantitative	quantitative	ADJ
admet-628	16	7	tool	tool	NOUN
admet-628	16	8	to	to	PART
admet-628	16	9	evaluate	evaluate	VERB
admet-628	16	10	the	the	DET
admet-628	16	11	relationship	relationship	NOUN
admet-628	16	12	between	between	ADP
admet-628	16	13	an	an	DET
admet-628	16	14	externally	externally	ADV
admet-628	16	15	applied	apply	VERB
admet-628	16	16	dose	dose	NOUN
admet-628	16	17	of	of	ADP
admet-628	16	18	op	op	NOUN
admet-628	16	19	and	and	CCONJ
admet-628	16	20	the	the	DET
admet-628	16	21	internal	internal	ADJ
admet-628	16	22	tissue	tissue	NOUN
admet-628	16	23	doses	dose	NOUN
admet-628	16	24	in	in	ADP
admet-628	16	25	humans	human	NOUN
admet-628	16	26	.	.	PUNCT
admet-628	17	1	as	as	SCONJ
admet-628	17	2	such	such	DET
admet-628	17	3	the	the	DET
admet-628	17	4	model	model	NOUN
admet-628	17	5	can	can	AUX
admet-628	17	6	be	be	AUX
admet-628	17	7	used	use	VERB
admet-628	17	8	to	to	PART
admet-628	17	9	adjust	adjust	VERB
admet-628	17	10	the	the	DET
admet-628	17	11	dose	dose	NOUN
admet-628	17	12	regimens	regimen	NOUN
admet-628	17	13	for	for	ADP
admet-628	17	14	adult	adult	NOUN
admet-628	17	15	patients	patient	NOUN
admet-628	17	16	in	in	ADP
admet-628	17	17	disease	disease	NOUN
admet-628	17	18	states	state	NOUN
admet-628	17	19	e.g.	e.g.	ADV
admet-628	17	20	,	,	PUNCT
admet-628	17	21	renal	renal	ADJ
admet-628	17	22	failure	failure	NOUN
admet-628	17	23	and	and	CCONJ
admet-628	17	24	liver	liver	NOUN
admet-628	17	25	damage	damage	NOUN
admet-628	17	26	.	.	PUNCT
admet-628	18	1	keywords	keyword	VERB
admet-628	18	2	oseltamivir	oseltamivir	NOUN
admet-628	18	3	;	;	PUNCT
admet-628	18	4	physiologically	physiologically	ADV
admet-628	18	5	-	-	PUNCT
admet-628	18	6	based	base	VERB
admet-628	18	7	pharmacokinetic	pharmacokinetic	ADJ
admet-628	18	8	modelling	modelling	NOUN
admet-628	18	9	;	;	PUNCT
admet-628	18	10	tissue	tissue	NOUN
admet-628	18	11	concentration	concentration	NOUN
admet-628	18	12	;	;	PUNCT
admet-628	18	13	dose	dose	NOUN
admet-628	18	14	metrics	metric	NOUN
admet-628	18	15	introduction	introduction	NOUN
admet-628	18	16	oseltamivir	oseltamivir	PROPN
admet-628	18	17	phosphate	phosphate	PROPN
admet-628	18	18	(	(	PUNCT
admet-628	18	19	op	op	NOUN
admet-628	18	20	,	,	PUNCT
admet-628	18	21	tamiflu	tamiflu	PROPN
admet-628	18	22	®	®	PROPN
admet-628	18	23	)	)	PUNCT
admet-628	18	24	is	be	AUX
admet-628	18	25	an	an	DET
admet-628	18	26	effective	effective	ADJ
admet-628	18	27	prodrug	prodrug	NOUN
admet-628	18	28	for	for	ADP
admet-628	18	29	the	the	DET
admet-628	18	30	prevention	prevention	NOUN
admet-628	18	31	and	and	CCONJ
admet-628	18	32	treatment	treatment	NOUN
admet-628	18	33	of	of	ADP
admet-628	18	34	influenza	influenza	NOUN
admet-628	18	35	viral	viral	ADJ
admet-628	18	36	infection	infection	NOUN
admet-628	18	37	[	[	X
admet-628	18	38	1	1	NUM
admet-628	18	39	]	]	PUNCT
admet-628	18	40	.	.	PUNCT
admet-628	19	1	after	after	ADP
admet-628	19	2	oral	oral	ADJ
admet-628	19	3	dosing	dosing	NOUN
admet-628	19	4	,	,	PUNCT
admet-628	19	5	op	op	NOUN
admet-628	19	6	is	be	AUX
admet-628	19	7	rapidly	rapidly	ADV
admet-628	19	8	absorbed	absorb	VERB
admet-628	19	9	into	into	ADP
admet-628	19	10	the	the	DET
admet-628	19	11	systemic	systemic	ADJ
admet-628	19	12	circulation	circulation	NOUN
admet-628	19	13	of	of	ADP
admet-628	19	14	humans	human	NOUN
admet-628	19	15	and	and	CCONJ
admet-628	19	16	hydrolyzed	hydrolyze	VERB
admet-628	19	17	by	by	ADP
admet-628	19	18	the	the	DET
admet-628	19	19	carboxylesterase	carboxylesterase	NOUN
admet-628	19	20	enzymes	enzyme	NOUN
admet-628	19	21	in	in	ADP
admet-628	19	22	different	different	ADJ
admet-628	19	23	tissues	tissue	NOUN
admet-628	19	24	and	and	CCONJ
admet-628	19	25	organs	organ	NOUN
admet-628	19	26	to	to	ADP
admet-628	19	27	oseltamivir	oseltamivir	PROPN
admet-628	19	28	carboxylate	carboxylate	PROPN
admet-628	19	29	(	(	PUNCT
admet-628	19	30	oc	oc	PROPN
admet-628	19	31	)	)	PUNCT
admet-628	19	32	,	,	PUNCT
admet-628	19	33	a	a	DET
admet-628	19	34	potent	potent	ADJ
admet-628	19	35	inhibitor	inhibitor	NOUN
admet-628	19	36	of	of	ADP
admet-628	19	37	the	the	DET
admet-628	19	38	neuraminidase	neuraminidase	NOUN
admet-628	19	39	enzyme	enzyme	NOUN
admet-628	19	40	[	[	X
admet-628	19	41	2	2	NUM
admet-628	19	42	]	]	PUNCT
admet-628	19	43	(	(	PUNCT
admet-628	19	44	fig	fig	NOUN
admet-628	19	45	.	.	PUNCT
admet-628	20	1	1	1	NUM
admet-628	20	2	)	)	PUNCT
admet-628	20	3	.	.	PUNCT
admet-628	21	1	because	because	SCONJ
admet-628	21	2	influenza	influenza	NOUN
admet-628	21	3	virus	virus	NOUN
admet-628	21	4	needs	need	VERB
admet-628	21	5	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-628	21	6	mailto:gaogh@cde.org.cn	mailto:gaogh@cde.org.cn	X
admet-628	21	7	admet	admet	X
admet-628	21	8	&	&	CCONJ
admet-628	21	9	dmpk	dmpk	PROPN
admet-628	21	10	7(1	7(1	PROPN
admet-628	21	11	)	)	PUNCT
admet-628	21	12	(	(	PUNCT
admet-628	21	13	2019	2019	NUM
admet-628	21	14	)	)	PUNCT
admet-628	21	15	22	22	NUM
admet-628	21	16	-	-	SYM
admet-628	21	17	43	43	NUM
admet-628	21	18	a	a	DET
admet-628	21	19	physiologically	physiologically	ADV
admet-628	21	20	-	-	PUNCT
admet-628	21	21	based	base	VERB
admet-628	21	22	pharmacokinetic	pharmacokinetic	ADJ
admet-628	21	23	model	model	NOUN
admet-628	21	24	for	for	ADP
admet-628	21	25	oseltamivir	oseltamivir	PROPN
admet-628	21	26	doi	doi	PROPN
admet-628	21	27	:	:	PUNCT
admet-628	21	28	10.5599	10.5599	NUM
admet-628	21	29	/	/	SYM
admet-628	21	30	admet.628	admet.628	PROPN
admet-628	21	31	23	23	NUM
admet-628	21	32	neuraminidase	neuraminidase	NOUN
admet-628	21	33	to	to	PART
admet-628	21	34	grow	grow	VERB
admet-628	21	35	and	and	CCONJ
admet-628	21	36	duplicate	duplicate	VERB
admet-628	21	37	,	,	PUNCT
admet-628	21	38	oc	oc	PRON
admet-628	21	39	is	be	AUX
admet-628	21	40	able	able	ADJ
admet-628	21	41	to	to	PART
admet-628	21	42	reduce	reduce	VERB
admet-628	21	43	the	the	DET
admet-628	21	44	duration	duration	NOUN
admet-628	21	45	and	and	CCONJ
admet-628	21	46	severity	severity	NOUN
admet-628	21	47	of	of	ADP
admet-628	21	48	influenza	influenza	NOUN
admet-628	21	49	viral	viral	ADJ
admet-628	21	50	infection	infection	NOUN
admet-628	21	51	in	in	ADP
admet-628	21	52	humans	human	NOUN
admet-628	21	53	[	[	X
admet-628	21	54	3	3	NUM
admet-628	21	55	]	]	PUNCT
admet-628	21	56	.	.	PUNCT
admet-628	22	1	op	op	NOUN
admet-628	22	2	is	be	AUX
admet-628	22	3	a	a	DET
admet-628	22	4	drug	drug	NOUN
admet-628	22	5	with	with	ADP
admet-628	22	6	a	a	DET
admet-628	22	7	wide	wide	ADJ
admet-628	22	8	margin	margin	NOUN
admet-628	22	9	of	of	ADP
admet-628	22	10	safety	safety	NOUN
admet-628	22	11	.	.	PUNCT
admet-628	23	1	however	however	ADV
admet-628	23	2	,	,	PUNCT
admet-628	23	3	adverse	adverse	ADJ
admet-628	23	4	events	event	NOUN
admet-628	23	5	such	such	ADJ
admet-628	23	6	as	as	ADP
admet-628	23	7	abdominal	abdominal	ADJ
admet-628	23	8	pain	pain	NOUN
admet-628	23	9	,	,	PUNCT
admet-628	23	10	diarrhea	diarrhea	NOUN
admet-628	23	11	,	,	PUNCT
admet-628	23	12	nausea	nausea	NOUN
admet-628	23	13	,	,	PUNCT
admet-628	23	14	and	and	CCONJ
admet-628	23	15	skin	skin	NOUN
admet-628	23	16	reaction	reaction	NOUN
admet-628	23	17	have	have	AUX
admet-628	23	18	been	be	AUX
admet-628	23	19	reported	report	VERB
admet-628	23	20	during	during	ADP
admet-628	23	21	early	early	ADJ
admet-628	23	22	medication	medication	NOUN
admet-628	23	23	periods	period	NOUN
admet-628	23	24	especially	especially	ADV
admet-628	23	25	if	if	SCONJ
admet-628	23	26	the	the	DET
admet-628	23	27	oral	oral	ADJ
admet-628	23	28	dose	dose	NOUN
admet-628	23	29	is	be	AUX
admet-628	23	30	>	>	X
admet-628	23	31	200	200	NUM
admet-628	23	32	mg	mg	NUM
admet-628	23	33	op	op	NOUN
admet-628	23	34	b.i.d	b.i.d	PROPN
admet-628	23	35	.	.	PUNCT
admet-628	24	1	[	[	X
admet-628	24	2	3,4	3,4	NUM
admet-628	24	3	]	]	PUNCT
admet-628	24	4	.	.	PUNCT
admet-628	25	1	thus	thus	ADV
admet-628	25	2	neurological	neurological	ADJ
admet-628	25	3	symptoms	symptom	NOUN
admet-628	25	4	such	such	ADJ
admet-628	25	5	as	as	ADP
admet-628	25	6	headache	headache	NOUN
admet-628	25	7	,	,	PUNCT
admet-628	25	8	vertigo	vertigo	NOUN
admet-628	25	9	,	,	PUNCT
admet-628	25	10	somnolence	somnolence	NOUN
admet-628	25	11	,	,	PUNCT
admet-628	25	12	insomnia	insomnia	NOUN
admet-628	25	13	,	,	PUNCT
admet-628	25	14	numbness	numbness	NOUN
admet-628	25	15	,	,	PUNCT
admet-628	25	16	hyper	hyper	NOUN
admet-628	25	17	-	-	NOUN
admet-628	25	18	excitation	excitation	NOUN
admet-628	25	19	and	and	CCONJ
admet-628	25	20	an	an	DET
admet-628	25	21	increase	increase	NOUN
admet-628	25	22	in	in	ADP
admet-628	25	23	suicidal	suicidal	ADJ
admet-628	25	24	tendency	tendency	NOUN
admet-628	25	25	also	also	ADV
admet-628	25	26	have	have	AUX
admet-628	25	27	been	be	AUX
admet-628	25	28	reported	report	VERB
admet-628	25	29	in	in	ADP
admet-628	25	30	japanese	japanese	ADJ
admet-628	25	31	children	child	NOUN
admet-628	25	32	and	and	CCONJ
admet-628	25	33	young	young	ADJ
admet-628	25	34	adolescents	adolescent	NOUN
admet-628	25	35	[	[	X
admet-628	25	36	5,6	5,6	NUM
admet-628	25	37	]	]	X
admet-628	25	38	.	.	PUNCT
admet-628	26	1	the	the	DET
admet-628	26	2	mechanism(s	mechanism(s	NOUN
admet-628	26	3	)	)	PUNCT
admet-628	26	4	by	by	ADP
admet-628	26	5	which	which	PRON
admet-628	26	6	op	op	NOUN
admet-628	26	7	causes	cause	VERB
admet-628	26	8	neuropsychiatric	neuropsychiatric	ADJ
admet-628	26	9	effects	effect	NOUN
admet-628	26	10	remains	remain	VERB
admet-628	26	11	unclear	unclear	ADJ
admet-628	26	12	:	:	PUNCT
admet-628	26	13	toovey	toovey	VERB
admet-628	26	14	et	et	PROPN
admet-628	26	15	al	al	PROPN
admet-628	26	16	.	.	PUNCT
admet-628	27	1	[	[	X
admet-628	27	2	7	7	X
admet-628	27	3	]	]	PUNCT
admet-628	27	4	have	have	AUX
admet-628	27	5	suggested	suggest	VERB
admet-628	27	6	that	that	SCONJ
admet-628	27	7	since	since	SCONJ
admet-628	27	8	op	op	NOUN
admet-628	27	9	and	and	CCONJ
admet-628	27	10	oc	oc	NOUN
admet-628	27	11	are	be	AUX
admet-628	27	12	p	p	ADJ
admet-628	27	13	-	-	PUNCT
admet-628	27	14	glycoprotein	glycoprotein	NOUN
admet-628	27	15	substrates	substrate	NOUN
admet-628	27	16	[	[	X
admet-628	27	17	8	8	NUM
admet-628	27	18	]	]	PUNCT
admet-628	27	19	,	,	PUNCT
admet-628	27	20	little	little	ADJ
admet-628	27	21	or	or	CCONJ
admet-628	27	22	no	no	PRON
admet-628	27	23	op	op	NOUN
admet-628	27	24	/	/	SYM
admet-628	27	25	oc	oc	NOUN
admet-628	27	26	is	be	AUX
admet-628	27	27	able	able	ADJ
admet-628	27	28	to	to	PART
admet-628	27	29	penetrate	penetrate	VERB
admet-628	27	30	the	the	DET
admet-628	27	31	blood	blood	NOUN
admet-628	27	32	-	-	PUNCT
admet-628	27	33	brain	brain	NOUN
admet-628	27	34	barrier	barrier	NOUN
admet-628	27	35	of	of	ADP
admet-628	27	36	humans	human	NOUN
admet-628	27	37	and	and	CCONJ
admet-628	27	38	cause	cause	VERB
admet-628	27	39	neuropsychiatric	neuropsychiatric	ADJ
admet-628	27	40	effects	effect	NOUN
admet-628	28	1	[	[	X
admet-628	28	2	9	9	NUM
admet-628	28	3	]	]	PUNCT
admet-628	28	4	.	.	PUNCT
admet-628	29	1	conversely	conversely	ADV
admet-628	29	2	,	,	PUNCT
admet-628	29	3	op	op	NOUN
admet-628	29	4	has	have	AUX
admet-628	29	5	been	be	AUX
admet-628	29	6	shown	show	VERB
admet-628	29	7	to	to	PART
admet-628	29	8	block	block	VERB
admet-628	29	9	ganglioside	ganglioside	NOUN
admet-628	29	10	-	-	PUNCT
admet-628	29	11	regulated	regulate	VERB
admet-628	29	12	excitatory	excitatory	NOUN
admet-628	29	13	opioid	opioid	NOUN
admet-628	29	14	receptormediated	receptormediate	VERB
admet-628	29	15	hyperalgesia	hyperalgesia	NOUN
admet-628	29	16	and	and	CCONJ
admet-628	29	17	increase	increase	VERB
admet-628	29	18	opioid	opioid	ADJ
admet-628	29	19	analgesia	analgesia	NOUN
admet-628	29	20	in	in	ADP
admet-628	29	21	mice	mouse	NOUN
admet-628	29	22	[	[	X
admet-628	29	23	10,11	10,11	NOUN
admet-628	29	24	]	]	PUNCT
admet-628	29	25	.	.	PUNCT
admet-628	30	1	thus	thus	ADV
admet-628	30	2	,	,	PUNCT
admet-628	30	3	op	op	NOUN
admet-628	30	4	or	or	CCONJ
admet-628	30	5	oc	oc	PROPN
admet-628	30	6	may	may	AUX
admet-628	30	7	alter	alter	VERB
admet-628	30	8	the	the	DET
admet-628	30	9	neuronal	neuronal	ADJ
admet-628	30	10	excitability	excitability	NOUN
admet-628	30	11	of	of	ADP
admet-628	30	12	the	the	DET
admet-628	30	13	brain	brain	NOUN
admet-628	30	14	by	by	ADP
admet-628	30	15	increasing	increase	VERB
admet-628	30	16	the	the	DET
admet-628	30	17	synchronization	synchronization	NOUN
admet-628	30	18	of	of	ADP
admet-628	30	19	hippocampus	hippocampus	NOUN
admet-628	30	20	network	network	NOUN
admet-628	30	21	[	[	X
admet-628	30	22	12	12	NUM
admet-628	30	23	]	]	PUNCT
admet-628	30	24	.	.	PUNCT
admet-628	31	1	it	it	PRON
admet-628	31	2	is	be	AUX
admet-628	31	3	also	also	ADV
admet-628	31	4	possible	possible	ADJ
admet-628	31	5	that	that	SCONJ
admet-628	31	6	op	op	NOUN
admet-628	31	7	/	/	SYM
admet-628	31	8	oc	oc	AUX
admet-628	31	9	change	change	VERB
admet-628	31	10	human	human	ADJ
admet-628	31	11	behaviors	behavior	NOUN
admet-628	31	12	if	if	SCONJ
admet-628	31	13	the	the	DET
admet-628	31	14	blood	blood	NOUN
admet-628	31	15	-	-	PUNCT
admet-628	31	16	brain	brain	NOUN
admet-628	31	17	barrier	barrier	NOUN
admet-628	31	18	is	be	AUX
admet-628	31	19	immature	immature	ADJ
admet-628	31	20	or	or	CCONJ
admet-628	31	21	damaged	damage	VERB
admet-628	31	22	as	as	ADP
admet-628	31	23	in	in	ADP
admet-628	31	24	the	the	DET
admet-628	31	25	case	case	NOUN
admet-628	31	26	of	of	ADP
admet-628	31	27	young	young	ADJ
admet-628	31	28	children	child	NOUN
admet-628	31	29	.	.	PUNCT
admet-628	32	1	op	op	NOUN
admet-628	32	2	metabolic	metabolic	NOUN
admet-628	32	3	disposition	disposition	NOUN
admet-628	32	4	has	have	AUX
admet-628	32	5	been	be	AUX
admet-628	32	6	studied	study	VERB
admet-628	32	7	in	in	ADP
admet-628	32	8	rats	rat	NOUN
admet-628	32	9	[	[	X
admet-628	32	10	13	13	NUM
admet-628	32	11	]	]	PUNCT
admet-628	32	12	,	,	PUNCT
admet-628	32	13	ferrets	ferret	NOUN
admet-628	32	14	[	[	X
admet-628	32	15	14	14	NUM
admet-628	32	16	]	]	PUNCT
admet-628	32	17	and	and	CCONJ
admet-628	32	18	mice	mouse	NOUN
admet-628	33	1	[	[	X
admet-628	33	2	15	15	NUM
admet-628	33	3	]	]	PUNCT
admet-628	33	4	.	.	PUNCT
admet-628	34	1	the	the	DET
admet-628	34	2	oral	oral	ADJ
admet-628	34	3	bioavailability	bioavailability	NOUN
admet-628	34	4	of	of	ADP
admet-628	34	5	op	op	NOUN
admet-628	34	6	in	in	ADP
admet-628	34	7	these	these	DET
admet-628	34	8	animals	animal	NOUN
admet-628	34	9	ranges	range	VERB
admet-628	34	10	from	from	ADP
admet-628	34	11	30	30	NUM
admet-628	34	12	-	-	SYM
admet-628	34	13	73	73	NUM
admet-628	34	14	%	%	NOUN
admet-628	34	15	[	[	X
admet-628	34	16	16	16	NUM
admet-628	34	17	]	]	PUNCT
admet-628	34	18	but	but	CCONJ
admet-628	34	19	in	in	ADP
admet-628	34	20	humans	human	NOUN
admet-628	34	21	,	,	PUNCT
admet-628	34	22	it	it	PRON
admet-628	34	23	may	may	AUX
admet-628	34	24	reach	reach	VERB
admet-628	34	25	80	80	NUM
admet-628	34	26	%	%	NOUN
admet-628	34	27	.	.	PUNCT
admet-628	35	1	therapeutic	therapeutic	ADJ
admet-628	35	2	levels	level	NOUN
admet-628	35	3	of	of	ADP
admet-628	35	4	oc	oc	PART
admet-628	35	5	have	have	AUX
admet-628	35	6	been	be	AUX
admet-628	35	7	found	find	VERB
admet-628	35	8	in	in	ADP
admet-628	35	9	the	the	DET
admet-628	35	10	lungs	lung	NOUN
admet-628	35	11	,	,	PUNCT
admet-628	35	12	trachea	trachea	PROPN
admet-628	35	13	,	,	PUNCT
admet-628	35	14	nasal	nasal	ADJ
admet-628	35	15	mucosa	mucosa	NOUN
admet-628	35	16	of	of	ADP
admet-628	35	17	ferrets	ferret	NOUN
admet-628	35	18	[	[	X
admet-628	35	19	14	14	NUM
admet-628	35	20	]	]	PUNCT
admet-628	35	21	,	,	PUNCT
admet-628	35	22	and	and	CCONJ
admet-628	35	23	the	the	DET
admet-628	35	24	middle	middle	ADJ
admet-628	35	25	ear	ear	NOUN
admet-628	35	26	and	and	CCONJ
admet-628	35	27	sinuses	sinus	NOUN
admet-628	35	28	of	of	ADP
admet-628	35	29	humans	human	NOUN
admet-628	35	30	[	[	X
admet-628	35	31	17	17	NUM
admet-628	35	32	]	]	PUNCT
admet-628	35	33	.	.	PUNCT
admet-628	36	1	however	however	ADV
admet-628	36	2	,	,	PUNCT
admet-628	36	3	little	little	ADJ
admet-628	36	4	or	or	CCONJ
admet-628	36	5	no	no	PRON
admet-628	36	6	information	information	NOUN
admet-628	36	7	is	be	AUX
admet-628	36	8	available	available	ADJ
admet-628	36	9	on	on	ADP
admet-628	36	10	the	the	DET
admet-628	36	11	dose	dose	NOUN
admet-628	36	12	metrics	metric	NOUN
admet-628	36	13	of	of	ADP
admet-628	36	14	op	op	NOUN
admet-628	36	15	and	and	CCONJ
admet-628	36	16	oc	oc	NOUN
admet-628	36	17	in	in	ADP
admet-628	36	18	the	the	DET
admet-628	36	19	internal	internal	ADJ
admet-628	36	20	tissues	tissue	NOUN
admet-628	36	21	/	/	SYM
admet-628	36	22	organs	organ	NOUN
admet-628	36	23	of	of	ADP
admet-628	36	24	humans	human	NOUN
admet-628	36	25	.	.	PUNCT
admet-628	37	1	andersen	andersen	PROPN
admet-628	37	2	[	[	X
admet-628	37	3	18	18	NUM
admet-628	37	4	]	]	PUNCT
admet-628	37	5	has	have	AUX
admet-628	37	6	suggested	suggest	VERB
admet-628	37	7	using	use	VERB
admet-628	37	8	the	the	DET
admet-628	37	9	physiologically	physiologically	ADV
admet-628	37	10	based	base	VERB
admet-628	37	11	pharmacokinetic	pharmacokinetic	ADJ
admet-628	37	12	(	(	PUNCT
admet-628	37	13	pbpk	pbpk	ADJ
admet-628	37	14	)	)	PUNCT
admet-628	37	15	model	model	NOUN
admet-628	37	16	to	to	PART
admet-628	37	17	predict	predict	VERB
admet-628	37	18	the	the	DET
admet-628	37	19	pharmacokinetics	pharmacokinetic	NOUN
admet-628	37	20	and	and	CCONJ
admet-628	37	21	tissue	tissue	NOUN
admet-628	37	22	doses	dose	NOUN
admet-628	37	23	of	of	ADP
admet-628	37	24	environmental	environmental	ADJ
admet-628	37	25	chemicals	chemical	NOUN
admet-628	37	26	in	in	ADP
admet-628	37	27	humans	human	NOUN
admet-628	37	28	.	.	PUNCT
admet-628	38	1	moreover	moreover	ADV
admet-628	38	2	,	,	PUNCT
admet-628	38	3	by	by	ADP
admet-628	38	4	determining	determine	VERB
admet-628	38	5	the	the	DET
admet-628	38	6	relationship	relationship	NOUN
admet-628	38	7	between	between	ADP
admet-628	38	8	the	the	DET
admet-628	38	9	internal	internal	ADJ
admet-628	38	10	tissue	tissue	NOUN
admet-628	38	11	dose	dose	NOUN
admet-628	38	12	(	(	PUNCT
admet-628	38	13	instead	instead	ADV
admet-628	38	14	of	of	ADP
admet-628	38	15	the	the	DET
admet-628	38	16	external	external	ADJ
admet-628	38	17	dose	dose	NOUN
admet-628	38	18	)	)	PUNCT
admet-628	38	19	and	and	CCONJ
admet-628	38	20	the	the	DET
admet-628	38	21	pharmacological	pharmacological	ADJ
admet-628	38	22	or	or	CCONJ
admet-628	38	23	toxicological	toxicological	ADJ
admet-628	38	24	effects	effect	NOUN
admet-628	38	25	of	of	ADP
admet-628	38	26	xenobiotics	xenobiotic	NOUN
admet-628	38	27	,	,	PUNCT
admet-628	38	28	we	we	PRON
admet-628	38	29	can	can	AUX
admet-628	38	30	greatly	greatly	ADV
admet-628	38	31	improve	improve	VERB
admet-628	38	32	the	the	DET
admet-628	38	33	accuracy	accuracy	NOUN
admet-628	38	34	of	of	ADP
admet-628	38	35	the	the	DET
admet-628	38	36	dose	dose	NOUN
admet-628	38	37	-	-	PUNCT
admet-628	38	38	response	response	NOUN
admet-628	38	39	relationship	relationship	NOUN
admet-628	38	40	of	of	ADP
admet-628	38	41	prescription	prescription	NOUN
admet-628	38	42	drugs	drug	NOUN
admet-628	38	43	and	and	CCONJ
admet-628	38	44	chemicals	chemical	NOUN
admet-628	38	45	[	[	X
admet-628	38	46	19	19	NUM
admet-628	38	47	]	]	PUNCT
admet-628	38	48	.	.	PUNCT
admet-628	39	1	o	o	X
admet-628	39	2	nh	nh	PROPN
admet-628	39	3	2	2	NUM
admet-628	39	4	o	o	NOUN
admet-628	40	1	n	n	DET
admet-628	40	2	h	h	NOUN
admet-628	41	1	o	o	NOUN
admet-628	41	2	o	o	INTJ
admet-628	42	1	oh	oh	INTJ
admet-628	42	2	nh	nh	INTJ
admet-628	42	3	2	2	NUM
admet-628	42	4	o	o	NOUN
admet-628	43	1	n	n	DET
admet-628	43	2	h	h	NOUN
admet-628	43	3	o	o	NOUN
admet-628	43	4	o	o	X
admet-628	43	5	esterase	esterase	NOUN
admet-628	43	6	oseltamivir	oseltamivir	PROPN
admet-628	43	7	phosphate	phosphate	NOUN
admet-628	43	8	(	(	PUNCT
admet-628	43	9	op	op	NOUN
admet-628	43	10	)	)	PUNCT
admet-628	43	11	oseltamivir	oseltamivir	PROPN
admet-628	43	12	carboxylate	carboxylate	NOUN
admet-628	43	13	(	(	PUNCT
admet-628	43	14	oc	oc	PROPN
admet-628	43	15	)	)	PUNCT
admet-628	43	16	figure	figure	NOUN
admet-628	43	17	1	1	NUM
admet-628	43	18	.	.	PUNCT
admet-628	44	1	hydrolysis	hydrolysis	NOUN
admet-628	44	2	of	of	ADP
admet-628	44	3	oseltamivir	oseltamivir	PROPN
admet-628	44	4	phosphate	phosphate	VERB
admet-628	44	5	to	to	ADP
admet-628	44	6	oseltamivir	oseltamivir	PROPN
admet-628	44	7	carboxylate	carboxylate	PROPN
admet-628	44	8	hitherto	hitherto	NOUN
admet-628	44	9	,	,	PUNCT
admet-628	44	10	at	at	ADV
admet-628	44	11	least	least	ADV
admet-628	44	12	two	two	NUM
admet-628	44	13	different	different	ADJ
admet-628	44	14	op	op	NOUN
admet-628	44	15	pbpk	pbpk	NOUN
admet-628	44	16	models	model	NOUN
admet-628	44	17	have	have	AUX
admet-628	44	18	been	be	AUX
admet-628	44	19	reported	report	VERB
admet-628	44	20	for	for	ADP
admet-628	44	21	neonates	neonate	NOUN
admet-628	44	22	,	,	PUNCT
admet-628	44	23	infants	infant	NOUN
admet-628	44	24	and	and	CCONJ
admet-628	44	25	adult	adult	NOUN
admet-628	44	26	humans	human	NOUN
admet-628	44	27	[	[	X
admet-628	44	28	20,21	20,21	NUM
admet-628	44	29	]	]	PUNCT
admet-628	44	30	.	.	PUNCT
admet-628	45	1	none	none	NOUN
admet-628	45	2	of	of	ADP
admet-628	45	3	these	these	DET
admet-628	45	4	models	model	NOUN
admet-628	45	5	have	have	AUX
admet-628	45	6	been	be	AUX
admet-628	45	7	used	use	VERB
admet-628	45	8	to	to	PART
admet-628	45	9	predict	predict	VERB
admet-628	45	10	an	an	DET
admet-628	45	11	internal	internal	ADJ
admet-628	45	12	tissue	tissue	NOUN
admet-628	45	13	dose	dose	NOUN
admet-628	45	14	of	of	ADP
admet-628	45	15	op	op	NOUN
admet-628	45	16	/	/	SYM
admet-628	45	17	oc	oc	NOUN
admet-628	45	18	in	in	ADP
admet-628	45	19	humans	human	NOUN
admet-628	45	20	.	.	PUNCT
admet-628	46	1	parrott	parrott	PROPN
admet-628	46	2	et	et	PROPN
admet-628	46	3	al	al	PROPN
admet-628	46	4	.	.	PUNCT
admet-628	47	1	[	[	X
admet-628	47	2	20	20	NUM
admet-628	47	3	]	]	PUNCT
admet-628	47	4	first	first	ADV
admet-628	47	5	develop	develop	VERB
admet-628	47	6	an	an	DET
admet-628	47	7	oc	oc	NOUN
admet-628	47	8	pbpk	pbpk	ADJ
admet-628	47	9	model	model	NOUN
admet-628	47	10	in	in	ADP
admet-628	47	11	marmoset	marmoset	PROPN
admet-628	47	12	monkeys	monkey	NOUN
admet-628	47	13	and	and	CCONJ
admet-628	47	14	then	then	ADV
admet-628	47	15	extrapolate	extrapolate	VERB
admet-628	47	16	the	the	DET
admet-628	47	17	model	model	NOUN
admet-628	47	18	to	to	ADP
admet-628	47	19	young	young	ADJ
admet-628	47	20	children	child	NOUN
admet-628	47	21	.	.	PUNCT
admet-628	48	1	the	the	DET
admet-628	48	2	pbpk	pbpk	PROPN
admet-628	48	3	model	model	NOUN
admet-628	48	4	was	be	AUX
admet-628	48	5	developed	develop	VERB
admet-628	48	6	using	use	VERB
admet-628	48	7	a	a	DET
admet-628	48	8	multi	multi	ADJ
admet-628	48	9	-	-	ADJ
admet-628	48	10	compartment	compartment	ADJ
admet-628	48	11	permeability	permeability	NOUN
admet-628	48	12	-	-	PUNCT
admet-628	48	13	limited	limit	VERB
admet-628	48	14	liver	liver	NOUN
admet-628	48	15	.	.	PUNCT
admet-628	49	1	due	due	ADP
admet-628	49	2	to	to	ADP
admet-628	49	3	a	a	DET
admet-628	49	4	lack	lack	NOUN
admet-628	49	5	of	of	ADP
admet-628	49	6	tissue	tissue	NOUN
admet-628	49	7	distribution	distribution	NOUN
admet-628	49	8	data	datum	NOUN
admet-628	49	9	in	in	ADP
admet-628	49	10	monkeys	monkey	NOUN
admet-628	49	11	and	and	CCONJ
admet-628	49	12	humans	human	NOUN
admet-628	49	13	,	,	PUNCT
admet-628	49	14	the	the	DET
admet-628	49	15	pbpk	pbpk	PROPN
admet-628	49	16	model	model	NOUN
admet-628	49	17	needs	need	VERB
admet-628	49	18	refinement	refinement	NOUN
admet-628	49	19	and	and	CCONJ
admet-628	49	20	improvement	improvement	NOUN
admet-628	49	21	.	.	PUNCT
admet-628	50	1	the	the	DET
admet-628	50	2	aims	aim	NOUN
admet-628	50	3	of	of	ADP
admet-628	50	4	this	this	DET
admet-628	50	5	study	study	NOUN
admet-628	50	6	were	be	AUX
admet-628	50	7	to	to	PART
admet-628	50	8	develop	develop	VERB
admet-628	50	9	and	and	CCONJ
admet-628	50	10	validate	validate	VERB
admet-628	50	11	a	a	DET
admet-628	50	12	pbpk	pbpk	ADJ
admet-628	50	13	model	model	NOUN
admet-628	50	14	for	for	ADP
admet-628	50	15	op	op	NOUN
admet-628	50	16	/	/	SYM
admet-628	50	17	oc	oc	NOUN
admet-628	50	18	in	in	ADP
admet-628	50	19	rats	rat	NOUN
admet-628	50	20	,	,	PUNCT
admet-628	50	21	to	to	PART
admet-628	50	22	scale	scale	VERB
admet-628	50	23	up	up	ADP
admet-628	50	24	the	the	DET
admet-628	50	25	rat	rat	NOUN
admet-628	50	26	model	model	NOUN
admet-628	50	27	to	to	ADP
admet-628	50	28	humans	human	NOUN
admet-628	50	29	,	,	PUNCT
admet-628	50	30	and	and	CCONJ
admet-628	50	31	to	to	PART
admet-628	50	32	predict	predict	VERB
admet-628	50	33	the	the	DET
admet-628	50	34	internal	internal	ADJ
admet-628	50	35	tissue	tissue	NOUN
admet-628	50	36	doses	dose	NOUN
admet-628	50	37	of	of	ADP
admet-628	50	38	op	op	NOUN
admet-628	50	39	/	/	SYM
admet-628	50	40	oc	oc	NOUN
admet-628	50	41	in	in	ADP
admet-628	50	42	rats	rat	NOUN
admet-628	50	43	and	and	CCONJ
admet-628	50	44	humans	human	NOUN
admet-628	50	45	using	use	VERB
admet-628	50	46	peak	peak	NOUN
admet-628	50	47	concentration	concentration	NOUN
admet-628	50	48	(	(	PUNCT
admet-628	50	49	cmax	cmax	NOUN
admet-628	50	50	)	)	PUNCT
admet-628	50	51	and/or	and/or	CCONJ
admet-628	50	52	area	area	NOUN
admet-628	50	53	under	under	ADP
admet-628	50	54	the	the	DET
admet-628	50	55	curve	curve	NOUN
admet-628	50	56	(	(	PUNCT
admet-628	50	57	aucplasma	aucplasma	PROPN
admet-628	50	58	)	)	PUNCT
admet-628	50	59	of	of	ADP
admet-628	50	60	concentration	concentration	NOUN
admet-628	50	61	-	-	PUNCT
admet-628	50	62	time	time	NOUN
admet-628	50	63	curve	curve	NOUN
admet-628	50	64	as	as	ADP
admet-628	50	65	the	the	DET
admet-628	50	66	dose	dose	NOUN
admet-628	50	67	g.	g.	PROPN
admet-628	50	68	gao	gao	PROPN
admet-628	50	69	et	et	PROPN
admet-628	50	70	al	al	PROPN
admet-628	50	71	.	.	PROPN
admet-628	50	72	admet	admet	PROPN
admet-628	50	73	&	&	CCONJ
admet-628	50	74	dmpk	dmpk	PROPN
admet-628	50	75	7(1	7(1	PROPN
admet-628	50	76	)	)	PUNCT
admet-628	50	77	(	(	PUNCT
admet-628	50	78	2019	2019	NUM
admet-628	50	79	)	)	PUNCT
admet-628	50	80	22	22	NUM
admet-628	50	81	-	-	SYM
admet-628	50	82	43	43	NUM
admet-628	50	83	24	24	NUM
admet-628	50	84	surrogates	surrogate	NOUN
admet-628	50	85	.	.	PUNCT
admet-628	51	1	attempts	attempt	NOUN
admet-628	51	2	were	be	AUX
admet-628	51	3	made	make	VERB
admet-628	51	4	to	to	PART
admet-628	51	5	explain	explain	VERB
admet-628	51	6	the	the	DET
admet-628	51	7	therapeutic	therapeutic	ADJ
admet-628	51	8	and/or	and/or	CCONJ
admet-628	51	9	side	side	NOUN
admet-628	51	10	effects	effect	NOUN
admet-628	51	11	of	of	ADP
admet-628	51	12	op	op	NOUN
admet-628	51	13	in	in	ADP
admet-628	51	14	humans	human	NOUN
admet-628	51	15	using	use	VERB
admet-628	51	16	the	the	DET
admet-628	51	17	model	model	NOUN
admet-628	51	18	-	-	PUNCT
admet-628	51	19	predicted	predict	VERB
admet-628	51	20	dose	dose	NOUN
admet-628	51	21	metrics	metric	NOUN
admet-628	51	22	.	.	PUNCT
admet-628	52	1	since	since	SCONJ
admet-628	52	2	our	our	PRON
admet-628	52	3	op	op	NOUN
admet-628	52	4	/	/	SYM
admet-628	52	5	oc	oc	NOUN
admet-628	52	6	pbpk	pbpk	PROPN
admet-628	52	7	model	model	NOUN
admet-628	52	8	is	be	AUX
admet-628	52	9	based	base	VERB
admet-628	52	10	on	on	ADP
admet-628	52	11	the	the	DET
admet-628	52	12	actual	actual	ADJ
admet-628	52	13	anatomy	anatomy	NOUN
admet-628	52	14	and	and	CCONJ
admet-628	52	15	physiology	physiology	NOUN
admet-628	52	16	of	of	ADP
admet-628	52	17	rats	rat	NOUN
admet-628	52	18	(	(	PUNCT
admet-628	52	19	or	or	CCONJ
admet-628	52	20	humans	human	NOUN
admet-628	52	21	)	)	PUNCT
admet-628	52	22	and	and	CCONJ
admet-628	52	23	the	the	DET
admet-628	52	24	physicochemical	physicochemical	ADJ
admet-628	52	25	properties	property	NOUN
admet-628	52	26	of	of	ADP
admet-628	52	27	op	op	NOUN
admet-628	52	28	/	/	SYM
admet-628	52	29	oc	oc	NOUN
admet-628	52	30	,	,	PUNCT
admet-628	52	31	it	it	PRON
admet-628	52	32	should	should	AUX
admet-628	52	33	be	be	AUX
admet-628	52	34	useful	useful	ADJ
admet-628	52	35	in	in	ADP
admet-628	52	36	predicting	predict	VERB
admet-628	52	37	the	the	DET
admet-628	52	38	internal	internal	ADJ
admet-628	52	39	tissue	tissue	NOUN
admet-628	52	40	doses	dose	NOUN
admet-628	52	41	of	of	ADP
admet-628	52	42	op	op	NOUN
admet-628	52	43	/	/	SYM
admet-628	52	44	oc	oc	NOUN
admet-628	52	45	across	across	ADP
admet-628	52	46	the	the	DET
admet-628	52	47	external	external	ADJ
admet-628	52	48	doses	dose	NOUN
admet-628	52	49	,	,	PUNCT
admet-628	52	50	administration	administration	NOUN
admet-628	52	51	routes	route	NOUN
admet-628	52	52	,	,	PUNCT
admet-628	52	53	and	and	CCONJ
admet-628	52	54	animal	animal	NOUN
admet-628	52	55	species	specie	NOUN
admet-628	52	56	[	[	X
admet-628	52	57	22	22	NUM
admet-628	52	58	]	]	PUNCT
admet-628	52	59	.	.	PUNCT
admet-628	53	1	materials	material	NOUN
admet-628	53	2	and	and	CCONJ
admet-628	53	3	methods	method	NOUN
admet-628	53	4	metabolic	metabolic	NOUN
admet-628	53	5	disposition	disposition	NOUN
admet-628	53	6	of	of	ADP
admet-628	53	7	op	op	NOUN
admet-628	53	8	in	in	ADP
admet-628	53	9	the	the	DET
admet-628	53	10	rat	rat	NOUN
admet-628	53	11	chemicals	chemical	NOUN
admet-628	53	12	.	.	PUNCT
admet-628	54	1	op	op	NOUN
admet-628	54	2	/	/	SYM
admet-628	54	3	oc	oc	NOUN
admet-628	54	4	standards	standard	NOUN
admet-628	54	5	were	be	AUX
admet-628	54	6	kindly	kindly	ADV
admet-628	54	7	donated	donate	VERB
admet-628	54	8	by	by	ADP
admet-628	54	9	hoffmann	hoffmann	PROPN
admet-628	54	10	-	-	PUNCT
admet-628	54	11	la	la	PROPN
admet-628	54	12	roche	roche	PROPN
admet-628	54	13	ltd	ltd	PROPN
admet-628	54	14	.	.	PROPN
admet-628	54	15	,	,	PUNCT
admet-628	54	16	switzerland	switzerland	PROPN
admet-628	54	17	.	.	PUNCT
admet-628	55	1	chemical	chemical	ADJ
admet-628	55	2	purity	purity	NOUN
admet-628	55	3	of	of	ADP
admet-628	55	4	both	both	DET
admet-628	55	5	chemicals	chemical	NOUN
admet-628	55	6	exceeded	exceed	VERB
admet-628	55	7	99	99	NUM
admet-628	55	8	%	%	NOUN
admet-628	55	9	.	.	PUNCT
admet-628	56	1	dichlorvos	dichlorvos	NOUN
admet-628	56	2	was	be	AUX
admet-628	56	3	purchased	purchase	VERB
admet-628	56	4	from	from	ADP
admet-628	56	5	supelco	supelco	NOUN
admet-628	56	6	(	(	PUNCT
admet-628	56	7	bellfonte	bellfonte	NOUN
admet-628	56	8	,	,	PUNCT
admet-628	56	9	pa	pa	PROPN
admet-628	56	10	,	,	PUNCT
admet-628	56	11	us	we	PRON
admet-628	56	12	)	)	PUNCT
admet-628	56	13	.	.	PUNCT
admet-628	57	1	analytical	analytical	ADJ
admet-628	57	2	grade	grade	NOUN
admet-628	57	3	diethyl	diethyl	NOUN
admet-628	57	4	ether	ether	NOUN
admet-628	57	5	and	and	CCONJ
admet-628	57	6	hplc	hplc	PROPN
admet-628	57	7	grade	grade	NOUN
admet-628	57	8	acetonitrile	acetonitrile	NOUN
admet-628	57	9	were	be	AUX
admet-628	57	10	purchased	purchase	VERB
admet-628	57	11	from	from	ADP
admet-628	57	12	labscan	labscan	PROPN
admet-628	57	13	asia	asia	PROPN
admet-628	57	14	co.	co.	PROPN
admet-628	57	15	ltd	ltd	PROPN
admet-628	57	16	(	(	PUNCT
admet-628	57	17	bangkok	bangkok	PROPN
admet-628	57	18	,	,	PUNCT
admet-628	57	19	thailand	thailand	PROPN
admet-628	57	20	)	)	PUNCT
admet-628	57	21	.	.	PUNCT
admet-628	58	1	animals	animal	NOUN
admet-628	58	2	.	.	PUNCT
admet-628	59	1	male	male	ADJ
admet-628	59	2	sprague	sprague	NOUN
admet-628	59	3	-	-	PUNCT
admet-628	59	4	dawley	dawley	NOUN
admet-628	59	5	rats	rat	NOUN
admet-628	59	6	weighing	weigh	VERB
admet-628	59	7	about	about	ADV
admet-628	59	8	250	250	NUM
admet-628	59	9	g	g	NOUN
admet-628	59	10	were	be	AUX
admet-628	59	11	purchased	purchase	VERB
admet-628	59	12	from	from	ADP
admet-628	59	13	the	the	DET
admet-628	59	14	chinese	chinese	PROPN
admet-628	59	15	university	university	PROPN
admet-628	59	16	of	of	ADP
admet-628	59	17	hong	hong	PROPN
admet-628	59	18	kong	kong	PROPN
admet-628	59	19	,	,	PUNCT
admet-628	59	20	hong	hong	PROPN
admet-628	59	21	kong	kong	PROPN
admet-628	59	22	.	.	PUNCT
admet-628	60	1	the	the	DET
admet-628	60	2	animals	animal	NOUN
admet-628	60	3	were	be	AUX
admet-628	60	4	maintained	maintain	VERB
admet-628	60	5	on	on	ADP
admet-628	60	6	a	a	DET
admet-628	60	7	constant	constant	ADJ
admet-628	60	8	light	light	ADJ
admet-628	60	9	-	-	PUNCT
admet-628	60	10	dark	dark	NOUN
admet-628	60	11	cycle	cycle	NOUN
admet-628	60	12	with	with	ADP
admet-628	60	13	light	light	NOUN
admet-628	60	14	from	from	ADP
admet-628	60	15	07:00	07:00	NUM
admet-628	60	16	to	to	ADP
admet-628	60	17	19:00	19:00	NUM
admet-628	60	18	h	h	NOUN
admet-628	60	19	and	and	CCONJ
admet-628	60	20	darkness	darkness	NOUN
admet-628	60	21	from	from	ADP
admet-628	60	22	19:00	19:00	NUM
admet-628	60	23	to	to	ADP
admet-628	60	24	07:00	07:00	NUM
admet-628	60	25	h.	h.	PROPN
admet-628	60	26	tap	tap	NOUN
admet-628	60	27	water	water	NOUN
admet-628	60	28	and	and	CCONJ
admet-628	60	29	food	food	NOUN
admet-628	60	30	were	be	AUX
admet-628	60	31	provided	provide	VERB
admet-628	60	32	ad	ad	NOUN
admet-628	60	33	libitum	libitum	NOUN
admet-628	60	34	.	.	PUNCT
admet-628	61	1	the	the	DET
admet-628	61	2	rats	rat	NOUN
admet-628	61	3	were	be	AUX
admet-628	61	4	used	use	VERB
admet-628	61	5	after	after	ADP
admet-628	61	6	a	a	DET
admet-628	61	7	7	7	NUM
admet-628	61	8	-	-	PUNCT
admet-628	61	9	day	day	NOUN
admet-628	61	10	acclimation	acclimation	NOUN
admet-628	61	11	period	period	NOUN
admet-628	61	12	.	.	PUNCT
admet-628	62	1	the	the	DET
admet-628	62	2	procedure	procedure	NOUN
admet-628	62	3	associated	associate	VERB
admet-628	62	4	with	with	ADP
admet-628	62	5	animal	animal	NOUN
admet-628	62	6	care	care	NOUN
admet-628	62	7	and	and	CCONJ
admet-628	62	8	experimentation	experimentation	NOUN
admet-628	62	9	was	be	AUX
admet-628	62	10	carried	carry	VERB
admet-628	62	11	out	out	ADP
admet-628	62	12	according	accord	VERB
admet-628	62	13	to	to	ADP
admet-628	62	14	the	the	DET
admet-628	62	15	hong	hong	PROPN
admet-628	62	16	kong	kong	PROPN
admet-628	62	17	council	council	PROPN
admet-628	62	18	on	on	ADP
admet-628	62	19	animal	animal	NOUN
admet-628	62	20	care	care	NOUN
admet-628	62	21	guidelines	guideline	NOUN
admet-628	62	22	and	and	CCONJ
admet-628	62	23	with	with	ADP
admet-628	62	24	formal	formal	ADJ
admet-628	62	25	approval	approval	NOUN
admet-628	62	26	of	of	ADP
admet-628	62	27	the	the	DET
admet-628	62	28	animal	animal	NOUN
admet-628	62	29	care	care	NOUN
admet-628	62	30	committee	committee	NOUN
admet-628	62	31	of	of	ADP
admet-628	62	32	the	the	DET
admet-628	62	33	hong	hong	PROPN
admet-628	62	34	kong	kong	PROPN
admet-628	62	35	baptist	baptist	PROPN
admet-628	62	36	university	university	PROPN
admet-628	62	37	.	.	PUNCT
admet-628	63	1	tissue	tissue	NOUN
admet-628	63	2	distribution	distribution	NOUN
admet-628	63	3	studies	study	NOUN
admet-628	63	4	.	.	PUNCT
admet-628	64	1	thirty	thirty	NUM
admet-628	64	2	rats	rat	NOUN
admet-628	64	3	were	be	AUX
admet-628	64	4	used	use	VERB
admet-628	64	5	in	in	ADP
admet-628	64	6	the	the	DET
admet-628	64	7	tissue	tissue	NOUN
admet-628	64	8	distribution	distribution	NOUN
admet-628	64	9	studies	study	NOUN
admet-628	64	10	.	.	PUNCT
admet-628	65	1	the	the	DET
admet-628	65	2	rats	rat	NOUN
admet-628	65	3	were	be	AUX
admet-628	65	4	assigned	assign	VERB
admet-628	65	5	randomly	randomly	ADV
admet-628	65	6	into	into	ADP
admet-628	65	7	two	two	NUM
admet-628	65	8	groups	group	NOUN
admet-628	65	9	of	of	ADP
admet-628	65	10	15	15	NUM
admet-628	65	11	rats	rat	NOUN
admet-628	65	12	each	each	PRON
admet-628	65	13	.	.	PUNCT
admet-628	66	1	after	after	ADP
admet-628	66	2	fasting	fast	VERB
admet-628	66	3	overnight	overnight	ADV
admet-628	66	4	,	,	PUNCT
admet-628	66	5	one	one	NUM
admet-628	66	6	group	group	NOUN
admet-628	66	7	of	of	ADP
admet-628	66	8	rats	rat	NOUN
admet-628	66	9	were	be	AUX
admet-628	66	10	given	give	VERB
admet-628	66	11	a	a	DET
admet-628	66	12	single	single	ADJ
admet-628	66	13	dose	dose	NOUN
admet-628	66	14	of	of	ADP
admet-628	66	15	10	10	NUM
admet-628	66	16	mg	mg	NUM
admet-628	66	17	/	/	SYM
admet-628	66	18	kg	kg	NOUN
admet-628	66	19	op	op	NOUN
admet-628	66	20	by	by	ADP
admet-628	66	21	gavage	gavage	NOUN
admet-628	66	22	.	.	PUNCT
admet-628	67	1	the	the	DET
admet-628	67	2	other	other	ADJ
admet-628	67	3	group	group	NOUN
admet-628	67	4	of	of	ADP
admet-628	67	5	rats	rat	NOUN
admet-628	67	6	received	receive	VERB
admet-628	67	7	50	50	NUM
admet-628	67	8	mg	mg	PROPN
admet-628	67	9	/	/	SYM
admet-628	67	10	kg	kg	NOUN
admet-628	67	11	op	op	NOUN
admet-628	67	12	.	.	PUNCT
admet-628	68	1	three	three	NUM
admet-628	68	2	rats	rat	NOUN
admet-628	68	3	from	from	ADP
admet-628	68	4	each	each	DET
admet-628	68	5	group	group	NOUN
admet-628	68	6	were	be	AUX
admet-628	68	7	selected	select	VERB
admet-628	68	8	randomly	randomly	ADV
admet-628	68	9	and	and	CCONJ
admet-628	68	10	euthanized	euthanize	VERB
admet-628	68	11	by	by	ADP
admet-628	68	12	diethyl	diethyl	NOUN
admet-628	68	13	ether	ether	NOUN
admet-628	68	14	at	at	ADP
admet-628	68	15	the	the	DET
admet-628	68	16	following	following	ADJ
admet-628	68	17	time	time	NOUN
admet-628	68	18	points	point	NOUN
admet-628	68	19	:	:	PUNCT
admet-628	68	20	0.5	0.5	NUM
admet-628	68	21	,	,	PUNCT
admet-628	68	22	2	2	NUM
admet-628	68	23	,	,	PUNCT
admet-628	68	24	3	3	NUM
admet-628	68	25	,	,	PUNCT
admet-628	68	26	6	6	NUM
admet-628	68	27	,	,	PUNCT
admet-628	68	28	and	and	CCONJ
admet-628	68	29	12	12	NUM
admet-628	68	30	h	h	NOUN
admet-628	68	31	post	post	ADJ
admet-628	68	32	-	-	ADJ
admet-628	68	33	dosing	dosing	ADJ
admet-628	68	34	for	for	ADP
admet-628	68	35	the	the	DET
admet-628	68	36	10	10	NUM
admet-628	68	37	mg	mg	PROPN
admet-628	68	38	/	/	SYM
admet-628	68	39	kg	kg	PROPN
admet-628	68	40	dose	dose	NOUN
admet-628	68	41	group	group	NOUN
admet-628	68	42	;	;	PUNCT
admet-628	68	43	0.5	0.5	NUM
admet-628	68	44	,	,	PUNCT
admet-628	68	45	2	2	NUM
admet-628	68	46	,	,	PUNCT
admet-628	68	47	3	3	NUM
admet-628	68	48	,	,	PUNCT
admet-628	68	49	6	6	NUM
admet-628	68	50	and	and	CCONJ
admet-628	68	51	10	10	NUM
admet-628	68	52	h	h	NOUN
admet-628	68	53	post	post	ADJ
admet-628	68	54	-	-	ADJ
admet-628	68	55	dosing	dosing	ADJ
admet-628	68	56	for	for	ADP
admet-628	68	57	the	the	DET
admet-628	68	58	50	50	NUM
admet-628	68	59	mg	mg	PROPN
admet-628	68	60	/	/	SYM
admet-628	68	61	kg	kg	PROPN
admet-628	68	62	dose	dose	NOUN
admet-628	68	63	group	group	NOUN
admet-628	68	64	.	.	PUNCT
admet-628	69	1	the	the	DET
admet-628	69	2	abdominal	abdominal	ADJ
admet-628	69	3	wall	wall	NOUN
admet-628	69	4	was	be	AUX
admet-628	69	5	opened	open	VERB
admet-628	69	6	and	and	CCONJ
admet-628	69	7	a	a	DET
admet-628	69	8	blood	blood	NOUN
admet-628	69	9	sample	sample	NOUN
admet-628	69	10	was	be	AUX
admet-628	69	11	withdrawn	withdraw	VERB
admet-628	69	12	by	by	ADP
admet-628	69	13	cardiac	cardiac	ADJ
admet-628	69	14	puncture	puncture	NOUN
admet-628	69	15	.	.	PUNCT
admet-628	70	1	the	the	DET
admet-628	70	2	blood	blood	NOUN
admet-628	70	3	samples	sample	NOUN
admet-628	70	4	were	be	AUX
admet-628	70	5	centrifuged	centrifuge	VERB
admet-628	70	6	immediately	immediately	ADV
admet-628	70	7	at	at	ADP
admet-628	70	8	3000	3000	NUM
admet-628	70	9	rpm	rpm	NOUN
admet-628	70	10	for	for	ADP
admet-628	70	11	10	10	NUM
admet-628	70	12	min	min	NOUN
admet-628	70	13	to	to	PART
admet-628	70	14	collect	collect	VERB
admet-628	70	15	the	the	DET
admet-628	70	16	plasma	plasma	NOUN
admet-628	70	17	.	.	PUNCT
admet-628	71	1	the	the	DET
admet-628	71	2	plasma	plasma	NOUN
admet-628	71	3	was	be	AUX
admet-628	71	4	put	put	VERB
admet-628	71	5	in	in	ADP
admet-628	71	6	a	a	DET
admet-628	71	7	centrifuge	centrifuge	NOUN
admet-628	71	8	tube	tube	NOUN
admet-628	71	9	containing	contain	VERB
admet-628	71	10	a	a	DET
admet-628	71	11	mixture	mixture	NOUN
admet-628	71	12	of	of	ADP
admet-628	71	13	sodium	sodium	NOUN
admet-628	71	14	heparin	heparin	NOUN
admet-628	71	15	and	and	CCONJ
admet-628	71	16	dichlorvos	dichlorvos	NOUN
admet-628	71	17	which	which	PRON
admet-628	71	18	was	be	AUX
admet-628	71	19	used	use	VERB
admet-628	71	20	to	to	PART
admet-628	71	21	inhibit	inhibit	VERB
admet-628	71	22	op	op	NOUN
admet-628	71	23	hydrolysis	hydrolysis	NOUN
admet-628	71	24	in	in	ADP
admet-628	71	25	the	the	DET
admet-628	71	26	sample	sample	NOUN
admet-628	71	27	[	[	X
admet-628	71	28	23	23	NUM
admet-628	71	29	]	]	PUNCT
admet-628	71	30	.	.	PUNCT
admet-628	72	1	the	the	DET
admet-628	72	2	liver	liver	NOUN
admet-628	72	3	,	,	PUNCT
admet-628	72	4	spleen	spleen	NOUN
admet-628	72	5	,	,	PUNCT
admet-628	72	6	lung	lung	NOUN
admet-628	72	7	,	,	PUNCT
admet-628	72	8	and	and	CCONJ
admet-628	72	9	kidney	kidney	NOUN
admet-628	72	10	were	be	AUX
admet-628	72	11	also	also	ADV
admet-628	72	12	removed	remove	VERB
admet-628	72	13	from	from	ADP
admet-628	72	14	the	the	DET
admet-628	72	15	rats	rat	NOUN
admet-628	72	16	.	.	PUNCT
admet-628	73	1	the	the	DET
admet-628	73	2	tissue	tissue	NOUN
admet-628	73	3	samples	sample	NOUN
admet-628	73	4	were	be	AUX
admet-628	73	5	rinsed	rinse	VERB
admet-628	73	6	briefly	briefly	ADV
admet-628	73	7	with	with	ADP
admet-628	73	8	distilled	distil	VERB
admet-628	73	9	water	water	NOUN
admet-628	73	10	,	,	PUNCT
admet-628	73	11	wiped	wipe	VERB
admet-628	73	12	dry	dry	ADJ
admet-628	73	13	with	with	ADP
admet-628	73	14	kimwipes	kimwipe	NOUN
admet-628	73	15	,	,	PUNCT
admet-628	73	16	and	and	CCONJ
admet-628	73	17	stored	store	VERB
admet-628	73	18	at	at	ADP
admet-628	73	19	-80	-80	NOUN
admet-628	73	20	°	°	ADP
admet-628	73	21	c	c	NOUN
admet-628	73	22	until	until	ADP
admet-628	73	23	analysis	analysis	NOUN
admet-628	73	24	.	.	PUNCT
admet-628	74	1	extraction	extraction	NOUN
admet-628	74	2	of	of	ADP
admet-628	74	3	op	op	NOUN
admet-628	74	4	and	and	CCONJ
admet-628	74	5	oc	oc	X
admet-628	74	6	from	from	ADP
admet-628	74	7	plasma	plasma	NOUN
admet-628	74	8	and	and	CCONJ
admet-628	74	9	tissue	tissue	NOUN
admet-628	74	10	samples	sample	NOUN
admet-628	74	11	.	.	PUNCT
admet-628	75	1	one	one	NUM
admet-628	75	2	gram	gram	NOUN
admet-628	75	3	of	of	ADP
admet-628	75	4	tissue	tissue	NOUN
admet-628	75	5	/	/	SYM
admet-628	75	6	organ	organ	NOUN
admet-628	75	7	(	(	PUNCT
admet-628	75	8	0.5	0.5	NUM
admet-628	75	9	g	g	NOUN
admet-628	75	10	for	for	ADP
admet-628	75	11	spleen	spleen	NOUN
admet-628	75	12	)	)	PUNCT
admet-628	75	13	was	be	AUX
admet-628	75	14	weighed	weigh	VERB
admet-628	75	15	accurately	accurately	ADV
admet-628	75	16	in	in	ADP
admet-628	75	17	a	a	DET
admet-628	75	18	test	test	NOUN
admet-628	75	19	tube	tube	NOUN
admet-628	75	20	.	.	PUNCT
admet-628	76	1	after	after	ADP
admet-628	76	2	adding	add	VERB
admet-628	76	3	distilled	distil	VERB
admet-628	76	4	water	water	NOUN
admet-628	76	5	(	(	PUNCT
admet-628	76	6	3	3	NUM
admet-628	76	7	ml	ml	NOUN
admet-628	76	8	)	)	PUNCT
admet-628	76	9	and	and	CCONJ
admet-628	76	10	dichlorvos	dichlorvos	NOUN
admet-628	76	11	(	(	PUNCT
admet-628	76	12	600	600	NUM
admet-628	76	13	µg	µg	NOUN
admet-628	76	14	)	)	PUNCT
admet-628	76	15	,	,	PUNCT
admet-628	76	16	the	the	DET
admet-628	76	17	tissue	tissue	NOUN
admet-628	76	18	/	/	SYM
admet-628	76	19	organ	organ	NOUN
admet-628	76	20	was	be	AUX
admet-628	76	21	homogenized	homogenize	VERB
admet-628	76	22	in	in	ADP
admet-628	76	23	a	a	DET
admet-628	76	24	kinemetica	kinemetica	PROPN
admet-628	76	25	gmbh	gmbh	NOUN
admet-628	76	26	homogenizer	homogenizer	NOUN
admet-628	76	27	(	(	PUNCT
admet-628	76	28	pcu-2	pcu-2	NOUN
admet-628	76	29	-	-	SYM
admet-628	76	30	110	110	NUM
admet-628	76	31	,	,	PUNCT
admet-628	76	32	switzerland	switzerland	PROPN
admet-628	76	33	)	)	PUNCT
admet-628	76	34	for	for	ADP
admet-628	76	35	about	about	ADV
admet-628	76	36	2	2	NUM
admet-628	76	37	min	min	NOUN
admet-628	76	38	.	.	PROPN
admet-628	76	39	a	a	DET
admet-628	76	40	0.2	0.2	NUM
admet-628	76	41	ml	ml	NOUN
admet-628	76	42	aliquot	aliquot	NOUN
admet-628	76	43	of	of	ADP
admet-628	76	44	the	the	DET
admet-628	76	45	tissue	tissue	NOUN
admet-628	76	46	homogenate	homogenate	NOUN
admet-628	76	47	(	(	PUNCT
admet-628	76	48	or	or	CCONJ
admet-628	76	49	plasma	plasma	NOUN
admet-628	76	50	)	)	PUNCT
admet-628	76	51	was	be	AUX
admet-628	76	52	added	add	VERB
admet-628	76	53	to	to	ADP
admet-628	76	54	0.8	0.8	NUM
admet-628	76	55	ml	ml	NOUN
admet-628	76	56	of	of	ADP
admet-628	76	57	acetonitrile	acetonitrile	NOUN
admet-628	76	58	/	/	SYM
admet-628	76	59	water	water	NOUN
admet-628	76	60	(	(	PUNCT
admet-628	76	61	3:1	3:1	NUM
admet-628	76	62	,	,	PUNCT
admet-628	76	63	v	v	NOUN
admet-628	76	64	/	/	SYM
admet-628	76	65	v	v	NOUN
admet-628	76	66	)	)	PUNCT
admet-628	76	67	in	in	ADP
admet-628	76	68	an	an	DET
admet-628	76	69	eppendorf	eppendorf	ADJ
admet-628	76	70	tube	tube	NOUN
admet-628	76	71	.	.	PUNCT
admet-628	77	1	the	the	DET
admet-628	77	2	content	content	NOUN
admet-628	77	3	in	in	ADP
admet-628	77	4	the	the	DET
admet-628	77	5	eppendorf	eppendorf	ADJ
admet-628	77	6	tube	tube	NOUN
admet-628	77	7	was	be	AUX
admet-628	77	8	mixed	mix	VERB
admet-628	77	9	by	by	ADP
admet-628	77	10	vortex	vortex	NOUN
admet-628	77	11	for	for	ADP
admet-628	77	12	1	1	NUM
admet-628	77	13	min	min	NOUN
admet-628	77	14	and	and	CCONJ
admet-628	77	15	then	then	ADV
admet-628	77	16	centrifuged	centrifuge	VERB
admet-628	77	17	at	at	ADP
admet-628	77	18	13000	13000	NUM
admet-628	77	19	rpm	rpm	NOUN
admet-628	77	20	for	for	ADP
admet-628	77	21	10	10	NUM
admet-628	77	22	min	min	NOUN
admet-628	77	23	.	.	PUNCT
admet-628	78	1	the	the	DET
admet-628	78	2	supernatant	supernatant	NOUN
admet-628	78	3	was	be	AUX
admet-628	78	4	removed	remove	VERB
admet-628	78	5	and	and	CCONJ
admet-628	78	6	stored	store	VERB
admet-628	78	7	at	at	ADP
admet-628	78	8	-80	-80	NOUN
admet-628	78	9	°	°	ADP
admet-628	78	10	c	c	NOUN
admet-628	78	11	until	until	ADP
admet-628	78	12	analysis	analysis	NOUN
admet-628	78	13	.	.	PUNCT
admet-628	79	1	lc	lc	PROPN
admet-628	79	2	/	/	SYM
admet-628	79	3	ms	ms	PROPN
admet-628	79	4	/	/	SYM
admet-628	79	5	ms	ms	NOUN
admet-628	79	6	analysis	analysis	NOUN
admet-628	79	7	of	of	ADP
admet-628	79	8	op	op	NOUN
admet-628	79	9	and	and	CCONJ
admet-628	79	10	oc	oc	PROPN
admet-628	79	11	.	.	NOUN
admet-628	80	1	frozen	frozen	ADJ
admet-628	80	2	tissue	tissue	NOUN
admet-628	80	3	extracts	extract	NOUN
admet-628	80	4	were	be	AUX
admet-628	80	5	thawed	thaw	VERB
admet-628	80	6	,	,	PUNCT
admet-628	80	7	diluted	dilute	VERB
admet-628	80	8	with	with	ADP
admet-628	80	9	the	the	DET
admet-628	80	10	mobile	mobile	ADJ
admet-628	80	11	phase	phase	NOUN
admet-628	80	12	,	,	PUNCT
admet-628	80	13	and	and	CCONJ
admet-628	80	14	injected	inject	VERB
admet-628	80	15	10.0	10.0	NUM
admet-628	80	16	µl	µl	NOUN
admet-628	80	17	of	of	ADP
admet-628	80	18	the	the	DET
admet-628	80	19	final	final	ADJ
admet-628	80	20	solution	solution	NOUN
admet-628	80	21	into	into	ADP
admet-628	80	22	the	the	DET
admet-628	80	23	hplc	hplc	NOUN
admet-628	80	24	.	.	PUNCT
admet-628	81	1	op	op	NOUN
admet-628	81	2	/	/	SYM
admet-628	81	3	oc	oc	NOUN
admet-628	81	4	in	in	ADP
admet-628	81	5	the	the	DET
admet-628	81	6	extracts	extract	NOUN
admet-628	81	7	was	be	AUX
admet-628	81	8	quantified	quantify	VERB
admet-628	81	9	using	use	VERB
admet-628	81	10	a	a	DET
admet-628	81	11	modified	modify	VERB
admet-628	81	12	lc	lc	PROPN
admet-628	81	13	/	/	SYM
admet-628	81	14	ms	ms	PROPN
admet-628	81	15	/	/	SYM
admet-628	81	16	ms	ms	NOUN
admet-628	81	17	procedure	procedure	NOUN
admet-628	81	18	reported	report	VERB
admet-628	81	19	by	by	ADP
admet-628	81	20	lindegardh	lindegardh	PROPN
admet-628	81	21	et	et	PROPN
admet-628	81	22	al	al	PROPN
admet-628	81	23	.	.	PUNCT
admet-628	82	1	[	[	X
admet-628	82	2	24	24	NUM
admet-628	82	3	]	]	PUNCT
admet-628	82	4	.	.	PUNCT
admet-628	83	1	briefly	briefly	NOUN
admet-628	83	2	,	,	PUNCT
admet-628	83	3	op	op	NOUN
admet-628	83	4	/	/	SYM
admet-628	83	5	oc	oc	NOUN
admet-628	83	6	separation	separation	NOUN
admet-628	83	7	was	be	AUX
admet-628	83	8	performed	perform	VERB
admet-628	83	9	on	on	ADP
admet-628	83	10	a	a	DET
admet-628	83	11	c18	c18	NOUN
admet-628	83	12	analytical	analytical	ADJ
admet-628	83	13	column	column	NOUN
admet-628	83	14	(	(	PUNCT
admet-628	83	15	ods-2	ods-2	ADP
admet-628	83	16	,	,	PUNCT
admet-628	83	17	150	150	NUM
admet-628	83	18	mm	mm	NOUN
admet-628	83	19	,	,	PUNCT
admet-628	83	20	5u	5u	NUM
admet-628	83	21	,	,	PUNCT
admet-628	83	22	waters	waters	PROPN
admet-628	83	23	corp	corp	PROPN
admet-628	83	24	.	.	PROPN
admet-628	83	25	milford	milford	PROPN
admet-628	83	26	,	,	PUNCT
admet-628	83	27	ma	ma	PROPN
admet-628	83	28	)	)	PUNCT
admet-628	83	29	in	in	ADP
admet-628	83	30	a	a	DET
admet-628	83	31	hp	hp	ADJ
admet-628	83	32	1100	1100	NUM
admet-628	83	33	system	system	NOUN
admet-628	83	34	(	(	PUNCT
admet-628	83	35	hewlett	hewlett	PROPN
admet-628	83	36	packard	packard	PROPN
admet-628	83	37	,	,	PUNCT
admet-628	83	38	santa	santa	PROPN
admet-628	83	39	clara	clara	PROPN
admet-628	83	40	,	,	PUNCT
admet-628	83	41	california	california	PROPN
admet-628	83	42	)	)	PUNCT
admet-628	83	43	preceded	precede	VERB
admet-628	83	44	by	by	ADP
admet-628	83	45	a	a	DET
admet-628	83	46	guard	guard	NOUN
admet-628	83	47	column	column	NOUN
admet-628	83	48	(	(	PUNCT
admet-628	83	49	2.1	2.1	NUM
admet-628	83	50	by	by	ADP
admet-628	83	51	5	5	NUM
admet-628	83	52	mm	mm	NOUN
admet-628	83	53	;	;	PUNCT
admet-628	83	54	particle	particle	NOUN
admet-628	83	55	size	size	NOUN
admet-628	83	56	,	,	PUNCT
admet-628	83	57	1.7	1.7	NUM
admet-628	83	58	µm	µm	NOUN
admet-628	83	59	)	)	PUNCT
admet-628	83	60	(	(	PUNCT
admet-628	83	61	waters	waters	PROPN
admet-628	83	62	corp	corp	PROPN
admet-628	83	63	.	.	PROPN
admet-628	83	64	milford	milford	PROPN
admet-628	83	65	,	,	PUNCT
admet-628	83	66	ma	ma	PROPN
admet-628	83	67	)	)	PUNCT
admet-628	83	68	.	.	PUNCT
admet-628	84	1	the	the	DET
admet-628	84	2	column	column	NOUN
admet-628	84	3	was	be	AUX
admet-628	84	4	maintained	maintain	VERB
admet-628	84	5	at	at	ADP
admet-628	84	6	26	26	NUM
admet-628	84	7	°	°	NOUN
admet-628	84	8	c	c	NOUN
admet-628	84	9	;	;	PUNCT
admet-628	84	10	it	it	PRON
admet-628	84	11	was	be	AUX
admet-628	84	12	eluted	elute	VERB
admet-628	84	13	isocratically	isocratically	ADV
admet-628	84	14	at	at	ADP
admet-628	84	15	a	a	DET
admet-628	84	16	flow	flow	NOUN
admet-628	84	17	rate	rate	NOUN
admet-628	84	18	of	of	ADP
admet-628	84	19	0.200	0.200	NUM
admet-628	84	20	ml	ml	NOUN
admet-628	84	21	/	/	SYM
admet-628	84	22	min	min	NOUN
admet-628	84	23	.	.	PUNCT
admet-628	85	1	the	the	DET
admet-628	85	2	hplc	hplc	PROPN
admet-628	85	3	mobile	mobile	NOUN
admet-628	85	4	phase	phase	NOUN
admet-628	85	5	consisted	consist	VERB
admet-628	85	6	of	of	ADP
admet-628	85	7	a	a	DET
admet-628	85	8	solution	solution	NOUN
admet-628	85	9	with	with	ADP
admet-628	85	10	an	an	DET
admet-628	85	11	equal	equal	ADJ
admet-628	85	12	volume	volume	NOUN
admet-628	85	13	of	of	ADP
admet-628	85	14	ammonium	ammonium	NOUN
admet-628	85	15	admet	admet	NOUN
admet-628	85	16	&	&	CCONJ
admet-628	85	17	dmpk	dmpk	PROPN
admet-628	85	18	7(1	7(1	PROPN
admet-628	85	19	)	)	PUNCT
admet-628	85	20	(	(	PUNCT
admet-628	85	21	2019	2019	NUM
admet-628	85	22	)	)	PUNCT
admet-628	85	23	22	22	NUM
admet-628	85	24	-	-	SYM
admet-628	85	25	43	43	NUM
admet-628	85	26	a	a	DET
admet-628	85	27	physiologically	physiologically	ADV
admet-628	85	28	-	-	PUNCT
admet-628	85	29	based	base	VERB
admet-628	85	30	pharmacokinetic	pharmacokinetic	ADJ
admet-628	85	31	model	model	NOUN
admet-628	85	32	for	for	ADP
admet-628	85	33	oseltamivir	oseltamivir	PROPN
admet-628	85	34	doi	doi	PROPN
admet-628	85	35	:	:	PUNCT
admet-628	85	36	10.5599	10.5599	NUM
admet-628	85	37	/	/	SYM
admet-628	85	38	admet.628	admet.628	PROPN
admet-628	85	39	25	25	NUM
admet-628	85	40	formate	formate	NOUN
admet-628	85	41	(	(	PUNCT
admet-628	85	42	8.0	8.0	NUM
admet-628	85	43	mm	mm	NOUN
admet-628	85	44	)	)	PUNCT
admet-628	85	45	and	and	CCONJ
admet-628	85	46	methanol	methanol	NOUN
admet-628	85	47	.	.	PUNCT
admet-628	86	1	the	the	DET
admet-628	86	2	solution	solution	NOUN
admet-628	86	3	was	be	AUX
admet-628	86	4	adjusted	adjust	VERB
admet-628	86	5	to	to	ADP
admet-628	86	6	ph	ph	PROPN
admet-628	86	7	3.50	3.50	NUM
admet-628	86	8	with	with	ADP
admet-628	86	9	formic	formic	ADJ
admet-628	86	10	acid	acid	NOUN
admet-628	86	11	.	.	PUNCT
admet-628	87	1	the	the	DET
admet-628	87	2	analysis	analysis	NOUN
admet-628	87	3	employed	employ	VERB
admet-628	87	4	an	an	DET
admet-628	87	5	api	api	NOUN
admet-628	87	6	3200tm	3200tm	ADJ
admet-628	87	7	triple	triple	ADJ
admet-628	87	8	quadrupole	quadrupole	NOUN
admet-628	87	9	mass	mass	NOUN
admet-628	87	10	spectrometer	spectrometer	NOUN
admet-628	87	11	(	(	PUNCT
admet-628	87	12	ap	ap	PROPN
admet-628	87	13	scienx	scienx	PROPN
admet-628	87	14	)	)	PUNCT
admet-628	87	15	equipped	equip	VERB
admet-628	87	16	with	with	ADP
admet-628	87	17	a	a	DET
admet-628	87	18	turbo	turbo	NOUN
admet-628	87	19	vtm	vtm	NOUN
admet-628	87	20	ion	ion	NOUN
admet-628	87	21	source	source	NOUN
admet-628	87	22	controlled	control	VERB
admet-628	87	23	by	by	ADP
admet-628	87	24	the	the	DET
admet-628	87	25	linac	linac	ADJ
admet-628	87	26	®	®	NOUN
admet-628	87	27	collision	collision	NOUN
admet-628	87	28	cell	cell	NOUN
admet-628	87	29	technology	technology	NOUN
admet-628	87	30	for	for	ADP
admet-628	87	31	output	output	NOUN
admet-628	87	32	scanning	scanning	NOUN
admet-628	87	33	.	.	PUNCT
admet-628	88	1	the	the	DET
admet-628	88	2	optimal	optimal	ADJ
admet-628	88	3	transitions	transition	NOUN
admet-628	88	4	were	be	AUX
admet-628	88	5	313.14	313.14	NUM
admet-628	88	6	m	m	NOUN
admet-628	88	7	/	/	SYM
admet-628	88	8	z	z	NOUN
admet-628	88	9	to	to	ADP
admet-628	88	10	224.92	224.92	NUM
admet-628	88	11	m	m	NOUN
admet-628	88	12	/	/	SYM
admet-628	88	13	z	z	NOUN
admet-628	88	14	for	for	ADP
admet-628	88	15	op	op	NOUN
admet-628	88	16	,	,	PUNCT
admet-628	88	17	285.2	285.2	NUM
admet-628	88	18	m	m	NOUN
admet-628	88	19	/	/	SYM
admet-628	88	20	z	z	NOUN
admet-628	88	21	to	to	ADP
admet-628	88	22	197.0	197.0	NUM
admet-628	88	23	m	m	NOUN
admet-628	88	24	/	/	SYM
admet-628	88	25	z	z	PROPN
admet-628	88	26	for	for	ADP
admet-628	88	27	oc	oc	PROPN
admet-628	88	28	.	.	PUNCT
admet-628	89	1	the	the	DET
admet-628	89	2	limits	limit	NOUN
admet-628	89	3	of	of	ADP
admet-628	89	4	detection	detection	NOUN
admet-628	89	5	for	for	ADP
admet-628	89	6	op	op	NOUN
admet-628	89	7	and	and	CCONJ
admet-628	89	8	oc	oc	NOUN
admet-628	89	9	were	be	AUX
admet-628	89	10	20	20	NUM
admet-628	89	11	and	and	CCONJ
admet-628	89	12	30	30	NUM
admet-628	89	13	pg	pg	NOUN
admet-628	89	14	/	/	SYM
admet-628	89	15	ml	ml	NOUN
admet-628	89	16	,	,	PUNCT
admet-628	89	17	respectively	respectively	ADV
admet-628	89	18	.	.	PUNCT
admet-628	90	1	the	the	DET
admet-628	90	2	limits	limit	NOUN
admet-628	90	3	of	of	ADP
admet-628	90	4	quantification	quantification	NOUN
admet-628	90	5	ranged	range	VERB
admet-628	90	6	from	from	ADP
admet-628	90	7	0.4	0.4	NUM
admet-628	90	8	-	-	SYM
admet-628	90	9	0.6	0.6	NUM
admet-628	90	10	ng	ng	PROPN
admet-628	90	11	/	/	SYM
admet-628	90	12	ml	ml	X
admet-628	90	13	for	for	ADP
admet-628	90	14	plasma	plasma	NOUN
admet-628	90	15	and	and	CCONJ
admet-628	90	16	1.6	1.6	NUM
admet-628	90	17	-	-	SYM
admet-628	90	18	2.4	2.4	NUM
admet-628	90	19	ng	ng	PROPN
admet-628	90	20	/	/	SYM
admet-628	90	21	g	g	NOUN
admet-628	90	22	for	for	ADP
admet-628	90	23	tissues	tissue	NOUN
admet-628	90	24	.	.	PUNCT
admet-628	91	1	recoveries	recovery	NOUN
admet-628	91	2	were	be	AUX
admet-628	91	3	achieved	achieve	VERB
admet-628	91	4	by	by	ADP
admet-628	91	5	comparing	compare	VERB
admet-628	91	6	op	op	NOUN
admet-628	91	7	/	/	SYM
admet-628	91	8	oc	oc	NOUN
admet-628	91	9	concentration	concentration	NOUN
admet-628	91	10	in	in	ADP
admet-628	91	11	the	the	DET
admet-628	91	12	extract	extract	NOUN
admet-628	91	13	to	to	ADP
admet-628	91	14	the	the	DET
admet-628	91	15	theoretical	theoretical	ADJ
admet-628	91	16	concentration	concentration	NOUN
admet-628	91	17	;	;	PUNCT
admet-628	91	18	they	they	PRON
admet-628	91	19	ranged	range	VERB
admet-628	91	20	from	from	ADP
admet-628	91	21	96	96	NUM
admet-628	91	22	%	%	NOUN
admet-628	91	23	to	to	ADP
admet-628	91	24	101	101	NUM
admet-628	91	25	%	%	NOUN
admet-628	91	26	in	in	ADP
admet-628	91	27	the	the	DET
admet-628	91	28	plasma	plasma	NOUN
admet-628	91	29	/	/	SYM
admet-628	91	30	tissue	tissue	NOUN
admet-628	91	31	samples	sample	NOUN
admet-628	91	32	.	.	PUNCT
admet-628	92	1	no	no	DET
admet-628	92	2	obvious	obvious	ADJ
admet-628	92	3	matrix	matrix	NOUN
admet-628	92	4	effects	effect	NOUN
admet-628	92	5	were	be	AUX
admet-628	92	6	detected	detect	VERB
admet-628	92	7	in	in	ADP
admet-628	92	8	the	the	DET
admet-628	92	9	tissues	tissue	NOUN
admet-628	92	10	within	within	ADP
admet-628	92	11	the	the	DET
admet-628	92	12	op	op	NOUN
admet-628	92	13	/	/	SYM
admet-628	92	14	oc	oc	NOUN
admet-628	92	15	concentration	concentration	NOUN
admet-628	92	16	ranges	range	NOUN
admet-628	92	17	used	use	VERB
admet-628	92	18	in	in	ADP
admet-628	92	19	this	this	DET
admet-628	92	20	study	study	NOUN
admet-628	92	21	.	.	PUNCT
admet-628	93	1	blood	blood	NOUN
admet-628	93	2	to	to	ADP
admet-628	93	3	plasma	plasma	NOUN
admet-628	93	4	ratio	ratio	NOUN
admet-628	93	5	.	.	PUNCT
admet-628	94	1	about	about	ADV
admet-628	94	2	2	2	NUM
admet-628	94	3	ml	ml	NOUN
admet-628	94	4	of	of	ADP
admet-628	94	5	freshly	freshly	ADV
admet-628	94	6	drawn	draw	VERB
admet-628	94	7	rat	rat	NOUN
admet-628	94	8	blood	blood	NOUN
admet-628	94	9	was	be	AUX
admet-628	94	10	mixed	mix	VERB
admet-628	94	11	with	with	ADP
admet-628	94	12	a	a	DET
admet-628	94	13	solution	solution	NOUN
admet-628	94	14	containing	contain	VERB
admet-628	94	15	of	of	ADP
admet-628	94	16	100	100	NUM
admet-628	94	17	µg	µg	ADJ
admet-628	94	18	/	/	SYM
admet-628	94	19	ml	ml	NOUN
admet-628	94	20	op	op	NOUN
admet-628	94	21	(	(	PUNCT
admet-628	94	22	or	or	CCONJ
admet-628	94	23	oc	oc	NOUN
admet-628	94	24	)	)	PUNCT
admet-628	94	25	standard	standard	NOUN
admet-628	94	26	and	and	CCONJ
admet-628	94	27	200	200	NUM
admet-628	94	28	µg	µg	ADJ
admet-628	94	29	/	/	SYM
admet-628	94	30	ml	ml	NOUN
admet-628	94	31	of	of	ADP
admet-628	94	32	dichlorvos	dichlorvos	NOUN
admet-628	94	33	.	.	PUNCT
admet-628	95	1	preliminary	preliminary	ADJ
admet-628	95	2	studies	study	NOUN
admet-628	95	3	indicated	indicate	VERB
admet-628	95	4	that	that	SCONJ
admet-628	95	5	equilibrium	equilibrium	NOUN
admet-628	95	6	between	between	ADP
admet-628	95	7	the	the	DET
admet-628	95	8	plasma	plasma	NOUN
admet-628	95	9	and	and	CCONJ
admet-628	95	10	blood	blood	NOUN
admet-628	95	11	for	for	ADP
admet-628	95	12	op	op	NOUN
admet-628	95	13	/	/	SYM
admet-628	95	14	oc	oc	NOUN
admet-628	95	15	was	be	AUX
admet-628	95	16	established	establish	VERB
admet-628	95	17	within	within	ADP
admet-628	95	18	20	20	NUM
admet-628	95	19	min	min	NOUN
admet-628	95	20	.	.	NOUN
admet-628	95	21	after	after	ADP
admet-628	95	22	incubating	incubate	VERB
admet-628	95	23	the	the	DET
admet-628	95	24	whole	whole	ADJ
admet-628	95	25	blood	blood	NOUN
admet-628	95	26	at	at	ADP
admet-628	95	27	37	37	NUM
admet-628	95	28	°	°	NOUN
admet-628	95	29	c	c	NOUN
admet-628	95	30	for	for	ADP
admet-628	95	31	30	30	NUM
admet-628	95	32	min	min	NOUN
admet-628	95	33	,	,	PUNCT
admet-628	95	34	an	an	DET
admet-628	95	35	aliquot	aliquot	NOUN
admet-628	95	36	was	be	AUX
admet-628	95	37	removed	remove	VERB
admet-628	95	38	and	and	CCONJ
admet-628	95	39	centrifuged	centrifuge	VERB
admet-628	95	40	at	at	ADP
admet-628	95	41	3000	3000	NUM
admet-628	95	42	rpm	rpm	NOUN
admet-628	95	43	for	for	ADP
admet-628	95	44	10	10	NUM
admet-628	95	45	min	min	NOUN
admet-628	95	46	to	to	PART
admet-628	95	47	obtain	obtain	VERB
admet-628	95	48	the	the	DET
admet-628	95	49	plasma	plasma	NOUN
admet-628	95	50	.	.	PUNCT
admet-628	96	1	op	op	NOUN
admet-628	96	2	and	and	CCONJ
admet-628	96	3	oc	oc	ADP
admet-628	96	4	concentrations	concentration	NOUN
admet-628	96	5	in	in	ADP
admet-628	96	6	the	the	DET
admet-628	96	7	plasma	plasma	NOUN
admet-628	96	8	were	be	AUX
admet-628	96	9	measured	measure	VERB
admet-628	96	10	by	by	ADP
admet-628	96	11	lc	lc	PROPN
admet-628	96	12	/	/	SYM
admet-628	96	13	ms	ms	PROPN
admet-628	96	14	/	/	SYM
admet-628	96	15	ms	ms	PROPN
admet-628	96	16	as	as	SCONJ
admet-628	96	17	described	describe	VERB
admet-628	96	18	above	above	ADV
admet-628	96	19	.	.	PUNCT
admet-628	97	1	op	op	NOUN
admet-628	97	2	and	and	CCONJ
admet-628	97	3	oc	oc	ADP
admet-628	97	4	concentrations	concentration	NOUN
admet-628	97	5	in	in	ADP
admet-628	97	6	the	the	DET
admet-628	97	7	blood	blood	NOUN
admet-628	97	8	were	be	AUX
admet-628	97	9	assumed	assume	VERB
admet-628	97	10	to	to	PART
admet-628	97	11	be	be	AUX
admet-628	97	12	the	the	DET
admet-628	97	13	theoretical	theoretical	ADJ
admet-628	97	14	concentrations	concentration	NOUN
admet-628	97	15	.	.	PUNCT
admet-628	98	1	blood	blood	NOUN
admet-628	98	2	/	/	SYM
admet-628	98	3	plasma	plasma	NOUN
admet-628	98	4	concentration	concentration	NOUN
admet-628	98	5	ratio	ratio	NOUN
admet-628	98	6	(	(	PUNCT
admet-628	98	7	blplr	blplr	NOUN
admet-628	98	8	)	)	PUNCT
admet-628	98	9	was	be	AUX
admet-628	98	10	calculated	calculate	VERB
admet-628	98	11	by	by	ADP
admet-628	98	12	dividing	divide	VERB
admet-628	98	13	the	the	DET
admet-628	98	14	concentration	concentration	NOUN
admet-628	98	15	of	of	ADP
admet-628	98	16	op	op	NOUN
admet-628	98	17	(	(	PUNCT
admet-628	98	18	or	or	CCONJ
admet-628	98	19	oc	oc	VERB
admet-628	98	20	)	)	PUNCT
admet-628	98	21	in	in	ADP
admet-628	98	22	the	the	DET
admet-628	98	23	whole	whole	ADJ
admet-628	98	24	blood	blood	NOUN
admet-628	98	25	with	with	ADP
admet-628	98	26	that	that	PRON
admet-628	98	27	in	in	ADP
admet-628	98	28	the	the	DET
admet-628	98	29	plasma	plasma	NOUN
admet-628	98	30	.	.	PUNCT
admet-628	99	1	the	the	DET
admet-628	99	2	blplr	blplr	NOUN
admet-628	99	3	of	of	ADP
admet-628	99	4	op	op	NOUN
admet-628	99	5	and	and	CCONJ
admet-628	99	6	oc	oc	NOUN
admet-628	99	7	was	be	AUX
admet-628	99	8	about	about	ADV
admet-628	99	9	1.0	1.0	NUM
admet-628	99	10	which	which	PRON
admet-628	99	11	indicated	indicate	VERB
admet-628	99	12	op	op	NOUN
admet-628	99	13	and	and	CCONJ
admet-628	99	14	oc	oc	AUX
admet-628	99	15	had	have	VERB
admet-628	99	16	similar	similar	ADJ
admet-628	99	17	protein	protein	NOUN
admet-628	99	18	binding	bind	VERB
admet-628	99	19	capacities	capacity	NOUN
admet-628	99	20	to	to	ADP
admet-628	99	21	blood	blood	NOUN
admet-628	99	22	and	and	CCONJ
admet-628	99	23	plasma	plasma	NOUN
admet-628	99	24	.	.	PUNCT
admet-628	100	1	op	op	NOUN
admet-628	100	2	metabolism	metabolism	NOUN
admet-628	100	3	by	by	ADP
admet-628	100	4	rat	rat	NOUN
admet-628	100	5	plasma	plasma	NOUN
admet-628	100	6	in	in	ADP
admet-628	100	7	vitro	vitro	VERB
admet-628	100	8	.	.	PUNCT
admet-628	101	1	in	in	ADP
admet-628	101	2	vitro	vitro	X
admet-628	101	3	op	op	NOUN
admet-628	101	4	metabolism	metabolism	NOUN
admet-628	101	5	was	be	AUX
admet-628	101	6	studied	study	VERB
admet-628	101	7	by	by	ADP
admet-628	101	8	incubating	incubate	VERB
admet-628	101	9	different	different	ADJ
admet-628	101	10	concentrations	concentration	NOUN
admet-628	101	11	of	of	ADP
admet-628	101	12	op	op	NOUN
admet-628	101	13	solution	solution	NOUN
admet-628	101	14	(	(	PUNCT
admet-628	101	15	0.1	0.1	NUM
admet-628	101	16	-	-	SYM
admet-628	101	17	0.5	0.5	NUM
admet-628	101	18	mg	mg	PROPN
admet-628	101	19	/	/	SYM
admet-628	101	20	ml	ml	NOUN
admet-628	101	21	)	)	PUNCT
admet-628	101	22	with	with	ADP
admet-628	101	23	30	30	NUM
admet-628	101	24	µl	µl	NOUN
admet-628	101	25	rat	rat	NOUN
admet-628	101	26	plasma	plasma	NOUN
admet-628	101	27	and	and	CCONJ
admet-628	101	28	tris	tris	ADJ
admet-628	101	29	-	-	PUNCT
admet-628	101	30	hcl	hcl	NOUN
admet-628	101	31	buffer	buffer	NOUN
admet-628	101	32	(	(	PUNCT
admet-628	101	33	ph	ph	NOUN
admet-628	101	34	7.4	7.4	NUM
admet-628	101	35	)	)	PUNCT
admet-628	101	36	in	in	ADP
admet-628	101	37	a	a	DET
admet-628	101	38	shaking	shake	VERB
admet-628	101	39	water	water	NOUN
admet-628	101	40	bath	bath	NOUN
admet-628	101	41	maintained	maintain	VERB
admet-628	101	42	at	at	ADP
admet-628	101	43	37	37	NUM
admet-628	101	44	°	°	NOUN
admet-628	101	45	c	c	NOUN
admet-628	101	46	.	.	PUNCT
admet-628	102	1	the	the	DET
admet-628	102	2	final	final	ADJ
admet-628	102	3	incubation	incubation	NOUN
admet-628	102	4	volume	volume	NOUN
admet-628	102	5	was	be	AUX
admet-628	102	6	200	200	NUM
admet-628	102	7	µl	µl	NOUN
admet-628	102	8	.	.	PUNCT
admet-628	103	1	control	control	NOUN
admet-628	103	2	incubation	incubation	NOUN
admet-628	103	3	was	be	AUX
admet-628	103	4	carried	carry	VERB
admet-628	103	5	out	out	ADP
admet-628	103	6	in	in	ADP
admet-628	103	7	a	a	DET
admet-628	103	8	similar	similar	ADJ
admet-628	103	9	manner	manner	NOUN
admet-628	103	10	but	but	CCONJ
admet-628	103	11	without	without	ADP
admet-628	103	12	rat	rat	NOUN
admet-628	103	13	plasma	plasma	NOUN
admet-628	103	14	.	.	PUNCT
admet-628	104	1	at	at	ADP
admet-628	104	2	1	1	NUM
admet-628	104	3	h	h	NOUN
admet-628	104	4	after	after	ADP
admet-628	104	5	incubation	incubation	NOUN
admet-628	104	6	,	,	PUNCT
admet-628	104	7	ice	ice	NOUN
admet-628	104	8	-	-	PUNCT
admet-628	104	9	cold	cold	ADJ
admet-628	104	10	acetonitrile	acetonitrile	NOUN
admet-628	104	11	(	(	PUNCT
admet-628	104	12	400	400	NUM
admet-628	104	13	µl	µl	NOUN
admet-628	104	14	)	)	PUNCT
admet-628	104	15	was	be	AUX
admet-628	104	16	used	use	VERB
admet-628	104	17	to	to	PART
admet-628	104	18	terminate	terminate	VERB
admet-628	104	19	the	the	DET
admet-628	104	20	hydrolysis	hydrolysis	NOUN
admet-628	104	21	reaction	reaction	NOUN
admet-628	104	22	.	.	PUNCT
admet-628	105	1	the	the	DET
admet-628	105	2	mixture	mixture	NOUN
admet-628	105	3	was	be	AUX
admet-628	105	4	centrifuged	centrifuge	VERB
admet-628	105	5	at	at	ADP
admet-628	105	6	13200	13200	NUM
admet-628	105	7	rpm	rpm	NOUN
admet-628	105	8	in	in	ADP
admet-628	105	9	a	a	DET
admet-628	105	10	4	4	NUM
admet-628	105	11	°	°	NOUN
admet-628	105	12	c	c	NOUN
admet-628	105	13	centrifuge	centrifuge	NOUN
admet-628	105	14	(	(	PUNCT
admet-628	105	15	model	model	NOUN
admet-628	105	16	5415r	5415r	NUM
admet-628	105	17	,	,	PUNCT
admet-628	105	18	eppendorf	eppendorf	PROPN
admet-628	105	19	ag	ag	PROPN
admet-628	105	20	,	,	PUNCT
admet-628	105	21	barkhausenweg	barkhausenweg	PROPN
admet-628	105	22	122339	122339	NUM
admet-628	105	23	hamburg	hamburg	PROPN
admet-628	105	24	,	,	PUNCT
admet-628	105	25	germany	germany	PROPN
admet-628	105	26	)	)	PUNCT
admet-628	105	27	for	for	SCONJ
admet-628	105	28	10	10	NUM
admet-628	105	29	min	min	NOUN
admet-628	105	30	to	to	PART
admet-628	105	31	separate	separate	VERB
admet-628	105	32	into	into	ADP
admet-628	105	33	layers	layer	NOUN
admet-628	105	34	.	.	PUNCT
admet-628	106	1	the	the	DET
admet-628	106	2	supernatant	supernatant	NOUN
admet-628	106	3	was	be	AUX
admet-628	106	4	transferred	transfer	VERB
admet-628	106	5	to	to	ADP
admet-628	106	6	an	an	DET
admet-628	106	7	hplc	hplc	NOUN
admet-628	106	8	vial	vial	ADJ
admet-628	106	9	and	and	CCONJ
admet-628	106	10	analyzed	analyze	VERB
admet-628	106	11	by	by	ADP
admet-628	106	12	a	a	DET
admet-628	106	13	hewlett	hewlett	PROPN
admet-628	106	14	packard	packard	PROPN
admet-628	106	15	1100	1100	NUM
admet-628	106	16	hplc	hplc	NOUN
admet-628	106	17	equipped	equip	VERB
admet-628	106	18	with	with	ADP
admet-628	106	19	a	a	DET
admet-628	106	20	uv	uv	NOUN
admet-628	106	21	detector	detector	NOUN
admet-628	106	22	.	.	PUNCT
admet-628	107	1	op	op	NOUN
admet-628	107	2	and	and	CCONJ
admet-628	107	3	oc	oc	PROPN
admet-628	107	4	were	be	AUX
admet-628	107	5	separated	separate	VERB
admet-628	107	6	on	on	ADP
admet-628	107	7	an	an	DET
admet-628	107	8	hplc	hplc	NOUN
admet-628	107	9	column	column	NOUN
admet-628	107	10	(	(	PUNCT
admet-628	107	11	ods-2	ods-2	ADP
admet-628	107	12	,	,	PUNCT
admet-628	107	13	150	150	NUM
admet-628	107	14	mm	mm	NOUN
admet-628	107	15	,	,	PUNCT
admet-628	107	16	5	5	NUM
admet-628	107	17	µm	µm	NOUN
admet-628	107	18	)	)	PUNCT
admet-628	107	19	using	use	VERB
admet-628	107	20	gradient	gradient	ADJ
admet-628	107	21	elution	elution	NOUN
admet-628	107	22	.	.	PUNCT
admet-628	108	1	the	the	DET
admet-628	108	2	mobile	mobile	ADJ
admet-628	108	3	phase	phase	NOUN
admet-628	108	4	consisted	consist	VERB
admet-628	108	5	of	of	ADP
admet-628	108	6	a	a	DET
admet-628	108	7	solution	solution	NOUN
admet-628	108	8	of	of	ADP
admet-628	108	9	0.4	0.4	NUM
admet-628	108	10	%	%	NOUN
admet-628	108	11	phosphoric	phosphoric	NOUN
admet-628	108	12	acid	acid	NOUN
admet-628	108	13	(	(	PUNCT
admet-628	108	14	ph	ph	NOUN
admet-628	108	15	3.0	3.0	NUM
admet-628	108	16	)	)	PUNCT
admet-628	108	17	and	and	CCONJ
admet-628	108	18	acetonitrile	acetonitrile	NOUN
admet-628	108	19	(	(	PUNCT
admet-628	108	20	80:20	80:20	NUM
admet-628	108	21	,	,	PUNCT
admet-628	108	22	v	v	NOUN
admet-628	108	23	/	/	SYM
admet-628	108	24	v	v	NOUN
admet-628	108	25	)	)	PUNCT
admet-628	108	26	.	.	PUNCT
admet-628	109	1	acetonitrile	acetonitrile	NOUN
admet-628	109	2	in	in	ADP
admet-628	109	3	the	the	DET
admet-628	109	4	mobile	mobile	ADJ
admet-628	109	5	phase	phase	NOUN
admet-628	109	6	increased	increase	VERB
admet-628	109	7	linearly	linearly	ADV
admet-628	109	8	from	from	ADP
admet-628	109	9	20	20	NUM
admet-628	109	10	%	%	NOUN
admet-628	109	11	to	to	ADP
admet-628	109	12	40	40	NUM
admet-628	109	13	%	%	NOUN
admet-628	109	14	in	in	ADP
admet-628	109	15	10	10	NUM
admet-628	109	16	min	min	NOUN
admet-628	109	17	.	.	PUNCT
admet-628	110	1	the	the	DET
admet-628	110	2	flow	flow	NOUN
admet-628	110	3	rate	rate	NOUN
admet-628	110	4	of	of	ADP
admet-628	110	5	the	the	DET
admet-628	110	6	mobile	mobile	ADJ
admet-628	110	7	phase	phase	NOUN
admet-628	110	8	was	be	AUX
admet-628	110	9	1	1	NUM
admet-628	110	10	ml	ml	NOUN
admet-628	110	11	/	/	SYM
admet-628	110	12	min	min	NOUN
admet-628	110	13	.	.	PUNCT
admet-628	111	1	the	the	DET
admet-628	111	2	detection	detection	NOUN
admet-628	111	3	wavelength	wavelength	NOUN
admet-628	111	4	was	be	AUX
admet-628	111	5	set	set	VERB
admet-628	111	6	at	at	ADP
admet-628	111	7	215	215	NUM
admet-628	111	8	nm	nm	NOUN
admet-628	111	9	.	.	PUNCT
admet-628	112	1	op	op	NOUN
admet-628	112	2	metabolism	metabolism	NOUN
admet-628	112	3	rate	rate	NOUN
admet-628	112	4	was	be	AUX
admet-628	112	5	expressed	express	VERB
admet-628	112	6	as	as	ADP
admet-628	112	7	µg	µg	ADV
admet-628	112	8	oc	oc	PART
admet-628	112	9	formed	form	VERB
admet-628	112	10	/	/	SYM
admet-628	112	11	ml	ml	ADP
admet-628	112	12	plasma	plasma	NOUN
admet-628	112	13	/	/	SYM
admet-628	112	14	h.	h.	PROPN
admet-628	113	1	the	the	DET
admet-628	113	2	vmax	vmax	PROPN
admet-628	113	3	and	and	CCONJ
admet-628	113	4	km	km	PROPN
admet-628	113	5	of	of	ADP
admet-628	113	6	op	op	NOUN
admet-628	113	7	metabolism	metabolism	NOUN
admet-628	113	8	were	be	AUX
admet-628	113	9	determined	determine	VERB
admet-628	113	10	using	use	VERB
admet-628	113	11	the	the	DET
admet-628	113	12	lineweaver	lineweaver	ADJ
admet-628	113	13	-	-	PUNCT
admet-628	113	14	burke	burke	NOUN
admet-628	113	15	plot	plot	NOUN
admet-628	113	16	and	and	CCONJ
admet-628	113	17	were	be	AUX
admet-628	113	18	found	find	VERB
admet-628	113	19	to	to	PART
admet-628	113	20	be	be	AUX
admet-628	113	21	61.2	61.2	NUM
admet-628	113	22	mg	mg	NOUN
admet-628	113	23	/	/	SYM
admet-628	113	24	h	h	NOUN
admet-628	113	25	and	and	CCONJ
admet-628	113	26	300	300	NUM
admet-628	113	27	mg	mg	PROPN
admet-628	113	28	/	/	SYM
admet-628	113	29	l	l	NOUN
admet-628	113	30	,	,	PUNCT
admet-628	113	31	respectively	respectively	ADV
admet-628	113	32	.	.	PUNCT
admet-628	114	1	pbpk	pbpk	NOUN
admet-628	114	2	modeling	modeling	NOUN
admet-628	114	3	of	of	ADP
admet-628	114	4	op	op	NOUN
admet-628	114	5	/	/	SYM
admet-628	114	6	oc	oc	NOUN
admet-628	114	7	in	in	ADP
admet-628	114	8	rats	rat	NOUN
admet-628	114	9	and	and	CCONJ
admet-628	114	10	humans	human	NOUN
admet-628	114	11	model	model	NOUN
admet-628	114	12	structure	structure	NOUN
admet-628	114	13	.	.	PUNCT
admet-628	115	1	fig	fig	NOUN
admet-628	115	2	.	.	PUNCT
admet-628	116	1	2	2	NUM
admet-628	116	2	shows	show	VERB
admet-628	116	3	a	a	DET
admet-628	116	4	schematic	schematic	ADJ
admet-628	116	5	diagram	diagram	NOUN
admet-628	116	6	of	of	ADP
admet-628	116	7	the	the	DET
admet-628	116	8	op	op	NOUN
admet-628	116	9	/	/	SYM
admet-628	116	10	oc	oc	NOUN
admet-628	116	11	pbpk	pbpk	ADJ
admet-628	116	12	model	model	NOUN
admet-628	116	13	in	in	ADP
admet-628	116	14	rats	rat	NOUN
admet-628	116	15	after	after	ADP
admet-628	116	16	oral	oral	ADJ
admet-628	116	17	administration	administration	NOUN
admet-628	116	18	.	.	PUNCT
admet-628	117	1	the	the	DET
admet-628	117	2	pbpk	pbpk	PROPN
admet-628	117	3	model	model	NOUN
admet-628	117	4	actually	actually	ADV
admet-628	117	5	consisted	consist	VERB
admet-628	117	6	of	of	ADP
admet-628	117	7	an	an	DET
admet-628	117	8	op	op	NOUN
admet-628	117	9	sub	sub	NOUN
admet-628	117	10	-	-	NOUN
admet-628	117	11	model	model	NOUN
admet-628	117	12	and	and	CCONJ
admet-628	117	13	an	an	DET
admet-628	117	14	oc	oc	NOUN
admet-628	117	15	sub	sub	NOUN
admet-628	117	16	-	-	NOUN
admet-628	117	17	model	model	NOUN
admet-628	117	18	.	.	PUNCT
admet-628	118	1	each	each	DET
admet-628	118	2	submodel	submodel	PROPN
admet-628	118	3	was	be	AUX
admet-628	118	4	composed	compose	VERB
admet-628	118	5	of	of	ADP
admet-628	118	6	9	9	NUM
admet-628	118	7	first	first	ADJ
admet-628	118	8	-	-	PUNCT
admet-628	118	9	order	order	NOUN
admet-628	118	10	flow	flow	NOUN
admet-628	118	11	-	-	PUNCT
admet-628	118	12	limited	limit	VERB
admet-628	118	13	tissue	tissue	NOUN
admet-628	118	14	compartments	compartment	NOUN
admet-628	118	15	:	:	PUNCT
admet-628	118	16	the	the	DET
admet-628	118	17	lung	lung	NOUN
admet-628	118	18	,	,	PUNCT
admet-628	118	19	kidney	kidney	NOUN
admet-628	118	20	,	,	PUNCT
admet-628	118	21	muscle	muscle	NOUN
admet-628	118	22	,	,	PUNCT
admet-628	118	23	brain	brain	NOUN
admet-628	118	24	,	,	PUNCT
admet-628	118	25	liver	liver	NOUN
admet-628	118	26	,	,	PUNCT
admet-628	118	27	spleen	spleen	NOUN
admet-628	118	28	,	,	PUNCT
admet-628	118	29	gut	gut	NOUN
admet-628	118	30	,	,	PUNCT
admet-628	118	31	blood	blood	NOUN
admet-628	118	32	and	and	CCONJ
admet-628	118	33	rest	rest	NOUN
admet-628	118	34	of	of	ADP
admet-628	118	35	body	body	NOUN
admet-628	118	36	.	.	PUNCT
admet-628	119	1	the	the	DET
admet-628	119	2	brain	brain	NOUN
admet-628	119	3	was	be	AUX
admet-628	119	4	lumped	lump	VERB
admet-628	119	5	with	with	ADP
admet-628	119	6	the	the	DET
admet-628	119	7	fat	fat	NOUN
admet-628	119	8	and	and	CCONJ
admet-628	119	9	the	the	DET
admet-628	119	10	lung	lung	NOUN
admet-628	119	11	was	be	AUX
admet-628	119	12	lumped	lump	VERB
admet-628	119	13	with	with	ADP
admet-628	119	14	the	the	DET
admet-628	119	15	heart	heart	NOUN
admet-628	119	16	because	because	SCONJ
admet-628	119	17	of	of	ADP
admet-628	119	18	possible	possible	ADJ
admet-628	119	19	similar	similar	ADJ
admet-628	119	20	tissue	tissue	NOUN
admet-628	119	21	/	/	SYM
admet-628	119	22	plasma	plasma	NOUN
admet-628	119	23	partition	partition	NOUN
admet-628	119	24	coefficients	coefficient	NOUN
admet-628	119	25	.	.	PUNCT
admet-628	120	1	the	the	DET
admet-628	120	2	rest	rest	NOUN
admet-628	120	3	of	of	ADP
admet-628	120	4	body	body	NOUN
admet-628	120	5	compartment	compartment	NOUN
admet-628	120	6	included	include	VERB
admet-628	120	7	all	all	DET
admet-628	120	8	other	other	ADJ
admet-628	120	9	tissues	tissue	NOUN
admet-628	120	10	which	which	PRON
admet-628	120	11	had	have	AUX
admet-628	120	12	not	not	PART
admet-628	120	13	been	be	AUX
admet-628	120	14	identified	identify	VERB
admet-628	120	15	in	in	ADP
admet-628	120	16	the	the	DET
admet-628	120	17	model	model	NOUN
admet-628	120	18	i.e.	i.e.	X
admet-628	120	19	,	,	PUNCT
admet-628	120	20	the	the	DET
admet-628	120	21	skin	skin	NOUN
admet-628	120	22	,	,	PUNCT
admet-628	120	23	bone	bone	NOUN
admet-628	120	24	,	,	PUNCT
admet-628	120	25	eye	eye	NOUN
admet-628	120	26	,	,	PUNCT
admet-628	120	27	prostate	prostate	NOUN
admet-628	120	28	gland	gland	NOUN
admet-628	120	29	,	,	PUNCT
admet-628	120	30	etc	etc	X
admet-628	120	31	.	.	X
admet-628	121	1	the	the	DET
admet-628	121	2	lung	lung	NOUN
admet-628	121	3	and	and	CCONJ
admet-628	121	4	the	the	DET
admet-628	121	5	brain	brain	NOUN
admet-628	121	6	are	be	AUX
admet-628	121	7	modeled	model	VERB
admet-628	121	8	as	as	ADP
admet-628	121	9	separate	separate	ADJ
admet-628	121	10	compartments	compartment	NOUN
admet-628	121	11	because	because	SCONJ
admet-628	121	12	h5n1	h5n1	PROPN
admet-628	121	13	influenza	influenza	NOUN
admet-628	121	14	virus	virus	NOUN
admet-628	121	15	mainly	mainly	ADV
admet-628	121	16	affected	affect	VERB
admet-628	121	17	the	the	DET
admet-628	121	18	respiratory	respiratory	ADJ
admet-628	121	19	tract	tract	NOUN
admet-628	121	20	and	and	CCONJ
admet-628	121	21	the	the	DET
admet-628	121	22	central	central	ADJ
admet-628	121	23	nervous	nervous	ADJ
admet-628	121	24	system	system	NOUN
admet-628	121	25	of	of	ADP
admet-628	121	26	japanese	japanese	ADJ
admet-628	121	27	children	child	NOUN
admet-628	121	28	after	after	ADP
admet-628	121	29	oral	oral	ADJ
admet-628	121	30	administration	administration	NOUN
admet-628	121	31	of	of	ADP
admet-628	121	32	op	op	NOUN
admet-628	122	1	[	[	X
admet-628	122	2	5,6	5,6	NUM
admet-628	122	3	]	]	X
admet-628	122	4	.	.	PUNCT
admet-628	123	1	absorption	absorption	NOUN
admet-628	123	2	of	of	ADP
admet-628	123	3	op	op	NOUN
admet-628	123	4	was	be	AUX
admet-628	123	5	assumed	assume	VERB
admet-628	123	6	to	to	PART
admet-628	123	7	be	be	AUX
admet-628	123	8	a	a	DET
admet-628	123	9	linear	linear	NOUN
admet-628	123	10	,	,	PUNCT
admet-628	123	11	first	first	ADJ
admet-628	123	12	-	-	PUNCT
admet-628	123	13	order	order	NOUN
admet-628	123	14	input	input	NOUN
admet-628	123	15	process	process	NOUN
admet-628	123	16	.	.	PUNCT
admet-628	124	1	after	after	ADP
admet-628	124	2	absorption	absorption	NOUN
admet-628	124	3	,	,	PUNCT
admet-628	124	4	op	op	NOUN
admet-628	124	5	was	be	AUX
admet-628	124	6	hydrolyzed	hydrolyze	VERB
admet-628	124	7	to	to	PART
admet-628	124	8	oc	oc	VERB
admet-628	124	9	mainly	mainly	ADV
admet-628	124	10	by	by	ADP
admet-628	124	11	the	the	DET
admet-628	124	12	carboxylesterases	carboxylesterase	NOUN
admet-628	124	13	in	in	ADP
admet-628	124	14	the	the	DET
admet-628	124	15	plasma	plasma	NOUN
admet-628	124	16	and	and	CCONJ
admet-628	124	17	the	the	DET
admet-628	124	18	liver	liver	NOUN
admet-628	124	19	.	.	PUNCT
admet-628	125	1	for	for	ADP
admet-628	125	2	the	the	DET
admet-628	125	3	purpose	purpose	NOUN
admet-628	125	4	of	of	ADP
admet-628	125	5	model	model	NOUN
admet-628	125	6	development	development	NOUN
admet-628	125	7	,	,	PUNCT
admet-628	125	8	op	op	NOUN
admet-628	125	9	metabolism	metabolism	NOUN
admet-628	125	10	was	be	AUX
admet-628	125	11	assumed	assume	VERB
admet-628	125	12	to	to	PART
admet-628	125	13	occur	occur	VERB
admet-628	125	14	only	only	ADV
admet-628	125	15	in	in	ADP
admet-628	125	16	the	the	DET
admet-628	125	17	liver	liver	NOUN
admet-628	125	18	which	which	PRON
admet-628	125	19	linked	link	VERB
admet-628	125	20	the	the	DET
admet-628	125	21	op	op	NOUN
admet-628	125	22	and	and	CCONJ
admet-628	125	23	oc	oc	VERB
admet-628	125	24	sub	sub	NOUN
admet-628	125	25	-	-	NOUN
admet-628	125	26	models	model	NOUN
admet-628	125	27	together	together	ADV
admet-628	125	28	(	(	PUNCT
admet-628	125	29	fig	fig	NOUN
admet-628	125	30	.	.	PUNCT
admet-628	126	1	2	2	NUM
admet-628	126	2	)	)	PUNCT
admet-628	126	3	.	.	PUNCT
admet-628	127	1	also	also	ADV
admet-628	127	2	,	,	PUNCT
admet-628	127	3	one	one	NUM
admet-628	127	4	mole	mole	NOUN
admet-628	127	5	of	of	ADP
admet-628	127	6	op	op	NOUN
admet-628	127	7	was	be	AUX
admet-628	127	8	converted	convert	VERB
admet-628	127	9	by	by	ADP
admet-628	127	10	the	the	DET
admet-628	127	11	carboxylesterase	carboxylesterase	NOUN
admet-628	127	12	g.	g.	PROPN
admet-628	127	13	gao	gao	PROPN
admet-628	127	14	et	et	PROPN
admet-628	127	15	al	al	PROPN
admet-628	127	16	.	.	PROPN
admet-628	127	17	admet	admet	PROPN
admet-628	127	18	&	&	CCONJ
admet-628	127	19	dmpk	dmpk	PROPN
admet-628	127	20	7(1	7(1	PROPN
admet-628	127	21	)	)	PUNCT
admet-628	127	22	(	(	PUNCT
admet-628	127	23	2019	2019	NUM
admet-628	127	24	)	)	PUNCT
admet-628	127	25	22	22	NUM
admet-628	127	26	-	-	SYM
admet-628	127	27	43	43	NUM
admet-628	127	28	26	26	NUM
admet-628	127	29	enzymes	enzyme	NOUN
admet-628	127	30	to	to	ADP
admet-628	127	31	one	one	NUM
admet-628	127	32	mole	mole	NOUN
admet-628	127	33	of	of	ADP
admet-628	127	34	oc	oc	PROPN
admet-628	127	35	.	.	PUNCT
admet-628	128	1	both	both	DET
admet-628	128	2	op	op	NOUN
admet-628	128	3	and	and	CCONJ
admet-628	128	4	oc	oc	PROPN
admet-628	128	5	were	be	AUX
admet-628	128	6	excreted	excrete	VERB
admet-628	128	7	into	into	ADP
admet-628	128	8	the	the	DET
admet-628	128	9	urine	urine	NOUN
admet-628	128	10	by	by	ADP
admet-628	128	11	the	the	DET
admet-628	128	12	kidney	kidney	NOUN
admet-628	128	13	.	.	PUNCT
admet-628	129	1	figure	figure	NOUN
admet-628	129	2	2	2	NUM
admet-628	129	3	.	.	PUNCT
admet-628	129	4	schematic	schematic	ADJ
admet-628	129	5	diagram	diagram	NOUN
admet-628	129	6	of	of	ADP
admet-628	129	7	the	the	DET
admet-628	129	8	physiologically	physiologically	ADV
admet-628	129	9	-	-	PUNCT
admet-628	129	10	based	base	VERB
admet-628	129	11	pharmacokinetic	pharmacokinetic	ADJ
admet-628	129	12	model	model	NOUN
admet-628	129	13	for	for	ADP
admet-628	129	14	rats	rat	NOUN
admet-628	129	15	or	or	CCONJ
admet-628	129	16	humans	human	NOUN
admet-628	129	17	after	after	ADP
admet-628	129	18	op	op	NOUN
admet-628	129	19	administration	administration	NOUN
admet-628	129	20	.	.	PUNCT
admet-628	130	1	c	c	PROPN
admet-628	130	2	represents	represent	VERB
admet-628	130	3	op	op	NOUN
admet-628	130	4	or	or	CCONJ
admet-628	130	5	oc	oc	ADP
admet-628	130	6	concentrations	concentration	NOUN
admet-628	130	7	(	(	PUNCT
admet-628	130	8	ng	ng	PROPN
admet-628	130	9	/	/	SYM
admet-628	130	10	g	g	PROPN
admet-628	130	11	or	or	CCONJ
admet-628	130	12	ng	ng	PROPN
admet-628	130	13	/	/	SYM
admet-628	130	14	ml	ml	PROPN
admet-628	130	15	)	)	PUNCT
admet-628	130	16	;	;	PUNCT
admet-628	130	17	q	q	PUNCT
admet-628	130	18	represents	represent	VERB
admet-628	130	19	plasma	plasma	NOUN
admet-628	130	20	flow	flow	NOUN
admet-628	130	21	rates	rate	NOUN
admet-628	130	22	(	(	PUNCT
admet-628	130	23	l	l	NOUN
admet-628	130	24	/	/	SYM
admet-628	130	25	h	h	NOUN
admet-628	130	26	)	)	PUNCT
admet-628	130	27	.	.	PUNCT
admet-628	131	1	the	the	DET
admet-628	131	2	subscripts	subscript	NOUN
admet-628	131	3	(	(	PUNCT
admet-628	131	4	p	p	NOUN
admet-628	131	5	or	or	CCONJ
admet-628	131	6	c	c	NOUN
admet-628	131	7	)	)	PUNCT
admet-628	131	8	under	under	ADP
admet-628	131	9	specific	specific	ADJ
admet-628	131	10	tissue	tissue	NOUN
admet-628	131	11	concentration	concentration	NOUN
admet-628	131	12	c	c	NOUN
admet-628	131	13	in	in	ADP
admet-628	131	14	the	the	DET
admet-628	131	15	sub	sub	NOUN
admet-628	131	16	-	-	NOUN
admet-628	131	17	models	model	NOUN
admet-628	131	18	refer	refer	VERB
admet-628	131	19	to	to	ADP
admet-628	131	20	op	op	NOUN
admet-628	131	21	or	or	CCONJ
admet-628	131	22	oc	oc	VERB
admet-628	131	23	,	,	PUNCT
admet-628	131	24	respectively	respectively	ADV
admet-628	131	25	physiological	physiological	ADJ
admet-628	131	26	parameters	parameter	NOUN
admet-628	131	27	.	.	PUNCT
admet-628	132	1	the	the	DET
admet-628	132	2	physiological	physiological	ADJ
admet-628	132	3	parameters	parameter	NOUN
admet-628	132	4	of	of	ADP
admet-628	132	5	the	the	DET
admet-628	132	6	rat	rat	NOUN
admet-628	132	7	pbpk	pbpk	NOUN
admet-628	132	8	model	model	NOUN
admet-628	132	9	were	be	AUX
admet-628	132	10	parameterized	parameterized	ADJ
admet-628	132	11	a	a	DET
admet-628	132	12	priori	priori	X
admet-628	132	13	(	(	PUNCT
admet-628	132	14	table	table	NOUN
admet-628	132	15	1	1	NUM
admet-628	132	16	)	)	PUNCT
admet-628	132	17	as	as	SCONJ
admet-628	132	18	follows	follow	VERB
admet-628	132	19	:	:	PUNCT
admet-628	132	20	tissue	tissue	NOUN
admet-628	132	21	volume	volume	NOUN
admet-628	132	22	and	and	CCONJ
admet-628	132	23	blood	blood	NOUN
admet-628	132	24	flow	flow	NOUN
admet-628	132	25	were	be	AUX
admet-628	132	26	taken	take	VERB
admet-628	132	27	from	from	ADP
admet-628	132	28	luttringer	luttringer	NOUN
admet-628	132	29	et	et	PROPN
admet-628	132	30	al	al	PROPN
admet-628	132	31	.	.	PUNCT
admet-628	133	1	[	[	X
admet-628	133	2	25	25	NUM
admet-628	133	3	]	]	PUNCT
admet-628	133	4	and	and	CCONJ
admet-628	133	5	from	from	ADP
admet-628	133	6	davies	davy	NOUN
admet-628	133	7	and	and	CCONJ
admet-628	133	8	morris	morris	PROPN
admet-628	133	9	[	[	X
admet-628	133	10	26	26	NUM
admet-628	133	11	]	]	X
admet-628	133	12	;	;	PUNCT
admet-628	133	13	these	these	DET
admet-628	133	14	parameter	parameter	NOUN
admet-628	133	15	values	value	NOUN
admet-628	133	16	were	be	AUX
admet-628	133	17	expressed	express	VERB
admet-628	133	18	as	as	ADP
admet-628	133	19	the	the	DET
admet-628	133	20	percentage	percentage	NOUN
admet-628	133	21	of	of	ADP
admet-628	133	22	total	total	ADJ
admet-628	133	23	body	body	NOUN
admet-628	133	24	volume	volume	NOUN
admet-628	133	25	or	or	CCONJ
admet-628	133	26	cardiac	cardiac	ADJ
admet-628	133	27	output	output	NOUN
admet-628	133	28	(	(	PUNCT
admet-628	133	29	co	co	NOUN
admet-628	133	30	)	)	PUNCT
admet-628	133	31	.	.	PUNCT
admet-628	134	1	total	total	ADJ
admet-628	134	2	blood	blood	NOUN
admet-628	134	3	volume	volume	NOUN
admet-628	134	4	was	be	AUX
admet-628	134	5	divided	divide	VERB
admet-628	134	6	into	into	ADP
admet-628	134	7	a	a	DET
admet-628	134	8	two	two	NUM
admet-628	134	9	-	-	PUNCT
admet-628	134	10	thirds	third	NOUN
admet-628	134	11	venous	venous	ADJ
admet-628	134	12	pool	pool	NOUN
admet-628	134	13	and	and	CCONJ
admet-628	134	14	one	one	NUM
admet-628	134	15	-	-	PUNCT
admet-628	134	16	third	third	ADJ
admet-628	134	17	arterial	arterial	ADJ
admet-628	134	18	pool	pool	NOUN
admet-628	134	19	.	.	PUNCT
admet-628	135	1	gut	gut	NOUN
admet-628	135	2	content	content	NOUN
admet-628	135	3	volumes	volume	NOUN
admet-628	135	4	was	be	AUX
admet-628	135	5	assumed	assume	VERB
admet-628	135	6	to	to	PART
admet-628	135	7	be	be	AUX
admet-628	135	8	0.014	0.014	NUM
admet-628	135	9	l	l	NOUN
admet-628	135	10	for	for	ADP
admet-628	135	11	a	a	DET
admet-628	135	12	0.25	0.25	NUM
admet-628	135	13	kg	kg	NOUN
admet-628	135	14	rat	rat	NOUN
admet-628	136	1	[	[	X
admet-628	136	2	27	27	NUM
admet-628	136	3	]	]	PUNCT
admet-628	136	4	.	.	PUNCT
admet-628	137	1	pharmacokinetic	pharmacokinetic	ADJ
admet-628	137	2	parameters	parameter	NOUN
admet-628	137	3	.	.	PUNCT
admet-628	138	1	absorption	absorption	NOUN
admet-628	138	2	rate	rate	NOUN
admet-628	138	3	constant	constant	ADJ
admet-628	138	4	(	(	PUNCT
admet-628	138	5	ka	ka	NOUN
admet-628	138	6	)	)	PUNCT
admet-628	138	7	of	of	ADP
admet-628	138	8	op	op	NOUN
admet-628	138	9	was	be	AUX
admet-628	138	10	determined	determine	VERB
admet-628	138	11	to	to	PART
admet-628	138	12	be	be	AUX
admet-628	138	13	0.76	0.76	NUM
admet-628	138	14	h-1	h-1	NOUN
admet-628	138	15	which	which	PRON
admet-628	138	16	was	be	AUX
admet-628	138	17	obtained	obtain	VERB
admet-628	138	18	by	by	ADP
admet-628	138	19	fitting	fit	VERB
admet-628	138	20	the	the	DET
admet-628	138	21	oc	oc	NOUN
admet-628	138	22	concentration	concentration	NOUN
admet-628	138	23	-	-	PUNCT
admet-628	138	24	time	time	NOUN
admet-628	138	25	curve	curve	NOUN
admet-628	138	26	in	in	ADP
admet-628	138	27	plasma	plasma	NOUN
admet-628	138	28	following	follow	VERB
admet-628	138	29	oral	oral	ADJ
admet-628	138	30	administration	administration	NOUN
admet-628	138	31	of	of	ADP
admet-628	138	32	10	10	NUM
admet-628	138	33	mg	mg	PROPN
admet-628	138	34	/	/	SYM
admet-628	138	35	kg	kg	NOUN
admet-628	138	36	of	of	ADP
admet-628	138	37	op	op	NOUN
admet-628	138	38	to	to	ADP
admet-628	138	39	a	a	DET
admet-628	138	40	classical	classical	ADJ
admet-628	138	41	,	,	PUNCT
admet-628	138	42	one	one	NUM
admet-628	138	43	-	-	PUNCT
admet-628	138	44	compartment	compartment	NOUN
admet-628	138	45	pharmacokinetic	pharmacokinetic	ADJ
admet-628	138	46	model	model	NOUN
admet-628	138	47	.	.	PUNCT
admet-628	139	1	considering	consider	VERB
admet-628	139	2	the	the	DET
admet-628	139	3	uncertainty	uncertainty	NOUN
admet-628	139	4	of	of	ADP
admet-628	139	5	the	the	DET
admet-628	139	6	absorption	absorption	NOUN
admet-628	139	7	related	relate	VERB
admet-628	139	8	parameters	parameter	NOUN
admet-628	139	9	,	,	PUNCT
admet-628	139	10	f	f	PROPN
admet-628	139	11	and	and	CCONJ
admet-628	139	12	ka	ka	PROPN
admet-628	139	13	were	be	AUX
admet-628	139	14	allowed	allow	VERB
admet-628	139	15	to	to	PART
admet-628	139	16	be	be	AUX
admet-628	139	17	optimized	optimize	VERB
admet-628	139	18	to	to	ADP
admet-628	139	19	a	a	DET
admet-628	139	20	reasonable	reasonable	ADJ
admet-628	139	21	extent	extent	NOUN
admet-628	139	22	during	during	ADP
admet-628	139	23	the	the	DET
admet-628	139	24	modelling	modelling	NOUN
admet-628	139	25	process	process	NOUN
admet-628	139	26	based	base	VERB
admet-628	139	27	on	on	ADP
admet-628	139	28	the	the	DET
admet-628	139	29	individual	individual	ADJ
admet-628	139	30	experimental	experimental	ADJ
admet-628	139	31	datasets	dataset	NOUN
admet-628	139	32	(	(	PUNCT
admet-628	139	33	table	table	NOUN
admet-628	139	34	2	2	NUM
admet-628	139	35	)	)	PUNCT
admet-628	139	36	.	.	PUNCT
admet-628	140	1	the	the	DET
admet-628	140	2	oral	oral	ADJ
admet-628	140	3	bioavailability	bioavailability	NOUN
admet-628	140	4	of	of	ADP
admet-628	140	5	op	op	NOUN
admet-628	140	6	was	be	AUX
admet-628	140	7	reported	report	VERB
admet-628	140	8	to	to	PART
admet-628	140	9	be	be	AUX
admet-628	140	10	0.35	0.35	NUM
admet-628	140	11	calculated	calculate	VERB
admet-628	140	12	by	by	ADP
admet-628	140	13	aucp.o	aucp.o	PROPN
admet-628	140	14	.	.	PUNCT
admet-628	141	1	(	(	PUNCT
admet-628	141	2	op)/auci.v.(oc	op)/auci.v.(oc	NOUN
admet-628	141	3	)	)	PUNCT
admet-628	141	4	ratio	ratio	NOUN
admet-628	141	5	,	,	PUNCT
admet-628	141	6	it	it	PRON
admet-628	141	7	should	should	AUX
admet-628	141	8	be	be	AUX
admet-628	141	9	noticed	notice	VERB
admet-628	141	10	that	that	SCONJ
admet-628	141	11	in	in	ADP
admet-628	141	12	the	the	DET
admet-628	141	13	pbpk	pbpk	PROPN
admet-628	141	14	model	model	NOUN
admet-628	141	15	f	f	PROPN
admet-628	141	16	represents	represent	VERB
admet-628	141	17	the	the	DET
admet-628	141	18	oral	oral	ADJ
admet-628	141	19	bioavailability	bioavailability	NOUN
admet-628	141	20	factor	factor	NOUN
admet-628	141	21	which	which	PRON
admet-628	141	22	was	be	AUX
admet-628	141	23	derived	derive	VERB
admet-628	141	24	from	from	ADP
admet-628	141	25	the	the	DET
admet-628	141	26	integrative	integrative	ADJ
admet-628	141	27	modeling	modeling	NOUN
admet-628	141	28	process	process	NOUN
admet-628	141	29	of	of	ADP
admet-628	141	30	the	the	DET
admet-628	141	31	pbpk	pbpk	ADJ
admet-628	141	32	model	model	NOUN
admet-628	141	33	for	for	ADP
admet-628	141	34	all	all	DET
admet-628	141	35	organs	organ	NOUN
admet-628	141	36	[	[	X
admet-628	141	37	28	28	NUM
admet-628	141	38	]	]	PUNCT
admet-628	141	39	and	and	CCONJ
admet-628	141	40	might	might	AUX
admet-628	141	41	be	be	AUX
admet-628	141	42	different	different	ADJ
admet-628	141	43	from	from	ADP
admet-628	141	44	the	the	DET
admet-628	141	45	experimental	experimental	ADJ
admet-628	141	46	absolute	absolute	ADJ
admet-628	141	47	bioavailability	bioavailability	NOUN
admet-628	141	48	(	(	PUNCT
admet-628	141	49	aucp.o./auci.v	aucp.o./auci.v	PROPN
admet-628	141	50	.	.	PUNCT
admet-628	141	51	)	)	PUNCT
admet-628	141	52	.	.	PUNCT
admet-628	142	1	the	the	DET
admet-628	142	2	clearance	clearance	NOUN
admet-628	142	3	(	(	PUNCT
admet-628	142	4	clc	clc	PROPN
admet-628	142	5	)	)	PUNCT
admet-628	142	6	of	of	ADP
admet-628	142	7	oc	oc	NOUN
admet-628	142	8	from	from	ADP
admet-628	142	9	rats	rat	NOUN
admet-628	142	10	was	be	AUX
admet-628	142	11	reported	report	VERB
admet-628	142	12	to	to	PART
admet-628	142	13	be	be	AUX
admet-628	142	14	0.38	0.38	NUM
admet-628	142	15	l	l	NOUN
admet-628	142	16	/	/	SYM
admet-628	142	17	h	h	NOUN
admet-628	142	18	after	after	ADP
admet-628	142	19	injecting	inject	VERB
admet-628	142	20	a	a	DET
admet-628	142	21	single	single	ADJ
admet-628	142	22	dose	dose	NOUN
admet-628	142	23	of	of	ADP
admet-628	142	24	10	10	NUM
admet-628	142	25	mg	mg	NOUN
admet-628	142	26	/	/	SYM
admet-628	142	27	kg	kg	PROPN
admet-628	142	28	intravenously	intravenously	ADV
admet-628	142	29	[	[	X
admet-628	142	30	15,16	15,16	NUM
admet-628	142	31	]	]	PUNCT
admet-628	142	32	.	.	PUNCT
admet-628	143	1	in	in	ADP
admet-628	143	2	vitro	vitro	X
admet-628	143	3	km	km	PROPN
admet-628	143	4	(	(	PUNCT
admet-628	143	5	300	300	NUM
admet-628	143	6	mg	mg	PROPN
admet-628	143	7	/	/	SYM
admet-628	143	8	l	l	NOUN
admet-628	143	9	)	)	PUNCT
admet-628	143	10	and	and	CCONJ
admet-628	143	11	vmax	vmax	X
admet-628	143	12	(	(	PUNCT
admet-628	143	13	61.2	61.2	NUM
admet-628	143	14	mg	mg	NUM
admet-628	143	15	/	/	SYM
admet-628	143	16	h	h	NOUN
admet-628	143	17	)	)	PUNCT
admet-628	143	18	values	value	NOUN
admet-628	143	19	were	be	AUX
admet-628	143	20	obtained	obtain	VERB
admet-628	143	21	by	by	ADP
admet-628	143	22	incubating	incubate	VERB
admet-628	143	23	op	op	NOUN
admet-628	143	24	with	with	ADP
admet-628	143	25	rat	rat	NOUN
admet-628	143	26	plasma	plasma	NOUN
admet-628	143	27	.	.	PUNCT
admet-628	144	1	fecal	fecal	ADJ
admet-628	144	2	excretion	excretion	NOUN
admet-628	144	3	rate	rate	NOUN
admet-628	144	4	constant	constant	ADJ
admet-628	144	5	(	(	PUNCT
admet-628	144	6	kf	kf	NOUN
admet-628	144	7	)	)	PUNCT
admet-628	144	8	was	be	AUX
admet-628	144	9	assumed	assume	VERB
admet-628	144	10	to	to	PART
admet-628	144	11	be	be	AUX
admet-628	144	12	1	1	NUM
admet-628	144	13	/	/	SYM
admet-628	144	14	transit	transit	NOUN
admet-628	144	15	time	time	NOUN
admet-628	144	16	of	of	ADP
admet-628	144	17	the	the	DET
admet-628	144	18	small	small	ADJ
admet-628	144	19	intestine	intestine	NOUN
admet-628	144	20	;	;	PUNCT
admet-628	144	21	the	the	DET
admet-628	144	22	transit	transit	NOUN
admet-628	144	23	time	time	NOUN
admet-628	144	24	of	of	ADP
admet-628	144	25	the	the	DET
admet-628	144	26	small	small	ADJ
admet-628	144	27	intestine	intestine	NOUN
admet-628	144	28	was	be	AUX
admet-628	144	29	taken	take	VERB
admet-628	144	30	from	from	ADP
admet-628	144	31	davies	davy	NOUN
admet-628	144	32	and	and	CCONJ
admet-628	144	33	morris	morris	PROPN
admet-628	145	1	[	[	X
admet-628	145	2	26	26	NUM
admet-628	145	3	]	]	PUNCT
admet-628	145	4	.	.	PUNCT
admet-628	146	1	admet	admet	PROPN
admet-628	146	2	&	&	CCONJ
admet-628	146	3	dmpk	dmpk	PROPN
admet-628	146	4	7(1	7(1	PROPN
admet-628	146	5	)	)	PUNCT
admet-628	146	6	(	(	PUNCT
admet-628	146	7	2019	2019	NUM
admet-628	146	8	)	)	PUNCT
admet-628	146	9	22	22	NUM
admet-628	146	10	-	-	SYM
admet-628	146	11	43	43	NUM
admet-628	146	12	a	a	DET
admet-628	146	13	physiologically	physiologically	ADV
admet-628	146	14	-	-	PUNCT
admet-628	146	15	based	base	VERB
admet-628	146	16	pharmacokinetic	pharmacokinetic	ADJ
admet-628	146	17	model	model	NOUN
admet-628	146	18	for	for	ADP
admet-628	146	19	oseltamivir	oseltamivir	PROPN
admet-628	146	20	doi	doi	PROPN
admet-628	146	21	:	:	PUNCT
admet-628	146	22	10.5599	10.5599	NUM
admet-628	146	23	/	/	SYM
admet-628	146	24	admet.628	admet.628	PROPN
admet-628	146	25	27	27	NUM
admet-628	146	26	table	table	NOUN
admet-628	146	27	1	1	NUM
admet-628	146	28	.	.	PUNCT
admet-628	146	29	physiological	physiological	ADJ
admet-628	146	30	parameters	parameter	NOUN
admet-628	146	31	of	of	ADP
admet-628	146	32	the	the	DET
admet-628	146	33	op	op	NOUN
admet-628	146	34	/	/	SYM
admet-628	146	35	oc	oc	NOUN
admet-628	146	36	pbpk	pbpk	ADJ
admet-628	146	37	model	model	NOUN
admet-628	146	38	in	in	ADP
admet-628	146	39	rats	rat	NOUN
admet-628	146	40	and	and	CCONJ
admet-628	146	41	humans	human	NOUN
admet-628	146	42	*	*	PUNCT
admet-628	146	43	parameter	parameter	NOUN
admet-628	146	44	organ	organ	NOUN
admet-628	146	45	weight	weight	NOUN
admet-628	146	46	(	(	PUNCT
admet-628	146	47	%	%	NOUN
admet-628	146	48	of	of	ADP
admet-628	146	49	body	body	NOUN
admet-628	146	50	weight	weight	NOUN
admet-628	146	51	)	)	PUNCT
admet-628	146	52	regional	regional	ADJ
admet-628	146	53	blood	blood	NOUN
admet-628	146	54	flow	flow	NOUN
admet-628	146	55	(	(	PUNCT
admet-628	146	56	%	%	NOUN
admet-628	146	57	of	of	ADP
admet-628	146	58	cardiac	cardiac	ADJ
admet-628	146	59	output	output	NOUN
admet-628	146	60	)	)	PUNCT
admet-628	146	61	partition	partition	NOUN
admet-628	146	62	coefficients	coefficient	NOUN
admet-628	146	63	tissue	tissue	NOUN
admet-628	146	64	rat	rat	NOUN
admet-628	146	65	human	human	ADJ
admet-628	146	66	rat	rat	NOUN
admet-628	146	67	human	human	ADJ
admet-628	146	68	op	op	NOUN
admet-628	146	69	oc	oc	ADP
admet-628	146	70	adipose	adipose	ADP
admet-628	146	71	7.6	7.6	NUM
admet-628	146	72	12	12	NUM
admet-628	146	73	7	7	NUM
admet-628	146	74	5	5	NUM
admet-628	146	75	brain	brain	NOUN
admet-628	146	76	0.57	0.57	NUM
admet-628	146	77	0.2	0.2	NUM
admet-628	146	78	2	2	NUM
admet-628	146	79	12	12	NUM
admet-628	146	80	lumped	lump	VERB
admet-628	146	81	brain	brain	NOUN
admet-628	146	82	8.13	8.13	NUM
admet-628	146	83	12.2	12.2	NUM
admet-628	146	84	9	9	NUM
admet-628	146	85	17	17	NUM
admet-628	146	86	0.5	0.5	NUM
admet-628	146	87	0.25	0.25	NUM
admet-628	146	88	heart	heart	NOUN
admet-628	146	89	0.33	0.33	NUM
admet-628	146	90	0.47	0.47	NUM
admet-628	146	91	lung	lung	NOUN
admet-628	146	92	0.5	0.5	NUM
admet-628	146	93	0.76	0.76	NUM
admet-628	146	94	lumped	lump	VERB
admet-628	146	95	lung	lung	NOUN
admet-628	146	96	0.83	0.83	NUM
admet-628	146	97	1.23	1.23	NUM
admet-628	146	98	2.5	2.5	NUM
admet-628	146	99	0.5	0.5	NUM
admet-628	146	100	kidney	kidney	NOUN
admet-628	146	101	0.73	0.73	NUM
admet-628	146	102	0.44	0.44	NUM
admet-628	146	103	14.1	14.1	NUM
admet-628	146	104	19	19	NUM
admet-628	146	105	5	5	NUM
admet-628	146	106	8	8	NUM
admet-628	146	107	liver	liver	NOUN
admet-628	146	108	3.66	3.66	NUM
admet-628	146	109	2.57	2.57	NUM
admet-628	146	110	32.6	32.6	NUM
admet-628	146	111	25	25	NUM
admet-628	146	112	3	3	NUM
admet-628	146	113	5	5	NUM
admet-628	146	114	gi	gi	NOUN
admet-628	146	115	tract	tract	VERB
admet-628	146	116	2.7	2.7	NUM
admet-628	146	117	1.7	1.7	NUM
admet-628	146	118	13.1	13.1	NUM
admet-628	146	119	17	17	NUM
admet-628	146	120	10	10	NUM
admet-628	146	121	1	1	NUM
admet-628	146	122	muscle	muscle	NOUN
admet-628	146	123	40.4	40.4	NUM
admet-628	146	124	40	40	NUM
admet-628	146	125	27.8	27.8	NUM
admet-628	146	126	17	17	NUM
admet-628	146	127	1.4	1.4	NUM
admet-628	146	128	0.5	0.5	NUM
admet-628	146	129	spleen	spleen	NOUN
admet-628	146	130	0.2	0.2	NUM
admet-628	146	131	0.26	0.26	NUM
admet-628	146	132	2	2	NUM
admet-628	146	133	2	2	NUM
admet-628	146	134	1.5	1.5	NUM
admet-628	146	135	0.5	0.5	NUM
admet-628	146	136	the	the	DET
admet-628	146	137	rest	rest	NOUN
admet-628	146	138	of	of	ADP
admet-628	146	139	body	body	NOUN
admet-628	146	140	*	*	PUNCT
admet-628	146	141	*	*	PUNCT
admet-628	146	142	43.4	43.4	NUM
admet-628	146	143	41.6	41.6	NUM
admet-628	146	144	16.5	16.5	NUM
admet-628	146	145	22	22	NUM
admet-628	146	146	3	3	NUM
admet-628	146	147	1	1	NUM
admet-628	146	148	total	total	NOUN
admet-628	146	149	100	100	NUM
admet-628	146	150	100	100	NUM
admet-628	146	151	100	100	NUM
admet-628	146	152	100	100	NUM
admet-628	147	1	*	*	PUNCT
admet-628	147	2	mean	mean	VERB
admet-628	147	3	data	datum	NOUN
admet-628	147	4	on	on	ADP
admet-628	147	5	tissue	tissue	NOUN
admet-628	147	6	blood	blood	NOUN
admet-628	147	7	flow	flow	NOUN
admet-628	147	8	rate	rate	NOUN
admet-628	147	9	and	and	CCONJ
admet-628	147	10	volume	volume	NOUN
admet-628	147	11	were	be	AUX
admet-628	147	12	adapted	adapt	VERB
admet-628	147	13	from	from	ADP
admet-628	147	14	luttringer	luttringer	ADP
admet-628	147	15	et	et	PROPN
admet-628	147	16	al	al	PROPN
admet-628	147	17	.	.	PUNCT
admet-628	148	1	[	[	X
admet-628	148	2	25	25	NUM
admet-628	148	3	]	]	PUNCT
admet-628	148	4	.	.	PUNCT
admet-628	149	1	organ	organ	NOUN
admet-628	149	2	weight	weight	NOUN
admet-628	149	3	was	be	AUX
admet-628	149	4	based	base	VERB
admet-628	149	5	on	on	ADP
admet-628	149	6	the	the	DET
admet-628	149	7	mean	mean	ADJ
admet-628	149	8	bw	bw	NOUN
admet-628	149	9	of	of	ADP
admet-628	149	10	a	a	DET
admet-628	149	11	0.26	0.26	NUM
admet-628	149	12	kg	kg	NOUN
admet-628	149	13	rat	rat	NOUN
admet-628	149	14	and	and	CCONJ
admet-628	149	15	a	a	DET
admet-628	149	16	70	70	NUM
admet-628	149	17	kg	kg	NOUN
admet-628	149	18	human	human	NOUN
admet-628	149	19	;	;	PUNCT
admet-628	149	20	cardiac	cardiac	ADJ
admet-628	149	21	output	output	NOUN
admet-628	149	22	for	for	ADP
admet-628	149	23	a	a	DET
admet-628	149	24	0.25	0.25	NUM
admet-628	149	25	kg	kg	NOUN
admet-628	149	26	rat	rat	NOUN
admet-628	149	27	is	be	AUX
admet-628	149	28	4.99	4.99	NUM
admet-628	149	29	l	l	NOUN
admet-628	149	30	/	/	SYM
admet-628	149	31	h	h	NOUN
admet-628	149	32	;	;	PUNCT
admet-628	149	33	it	it	PRON
admet-628	149	34	is	be	AUX
admet-628	149	35	calculated	calculate	VERB
admet-628	149	36	from	from	ADP
admet-628	149	37	the	the	DET
admet-628	149	38	equation	equation	NOUN
admet-628	149	39	,	,	PUNCT
admet-628	149	40	14.1*bw	14.1*bw	NUM
admet-628	149	41	0.75	0.75	NUM
admet-628	149	42	(	(	PUNCT
admet-628	149	43	l	l	NOUN
admet-628	149	44	/	/	SYM
admet-628	149	45	h	h	NOUN
admet-628	149	46	)	)	PUNCT
admet-628	149	47	.	.	PUNCT
admet-628	150	1	cardiac	cardiac	ADJ
admet-628	150	2	output	output	NOUN
admet-628	150	3	for	for	ADP
admet-628	150	4	a	a	DET
admet-628	150	5	70	70	NUM
admet-628	150	6	kg	kg	NOUN
admet-628	150	7	human	human	NOUN
admet-628	150	8	is	be	AUX
admet-628	150	9	390	390	NUM
admet-628	150	10	l	l	NOUN
admet-628	150	11	/	/	SYM
admet-628	150	12	h	h	NOUN
admet-628	150	13	;	;	PUNCT
admet-628	150	14	it	it	PRON
admet-628	150	15	is	be	AUX
admet-628	150	16	calculated	calculate	VERB
admet-628	150	17	from	from	ADP
admet-628	150	18	the	the	DET
admet-628	150	19	equation	equation	NOUN
admet-628	150	20	,	,	PUNCT
admet-628	150	21	16.1*bw	16.1*bw	NOUN
admet-628	150	22	0.75	0.75	NUM
admet-628	150	23	(	(	PUNCT
admet-628	150	24	l	l	NOUN
admet-628	150	25	/	/	SYM
admet-628	150	26	h	h	NOUN
admet-628	150	27	)	)	PUNCT
admet-628	150	28	.	.	PUNCT
admet-628	151	1	*	*	PUNCT
admet-628	151	2	*	*	PUNCT
admet-628	151	3	the	the	DET
admet-628	151	4	brain	brain	NOUN
admet-628	151	5	was	be	AUX
admet-628	151	6	lumped	lump	VERB
admet-628	151	7	into	into	ADP
admet-628	151	8	the	the	DET
admet-628	151	9	adipose	adipose	ADJ
admet-628	151	10	tissues	tissue	NOUN
admet-628	151	11	to	to	PART
admet-628	151	12	form	form	VERB
admet-628	151	13	the	the	DET
admet-628	151	14	“	"	PUNCT
admet-628	151	15	brain	brain	NOUN
admet-628	151	16	compartment	compartment	NOUN
admet-628	151	17	”	"	PUNCT
admet-628	151	18	;	;	PUNCT
admet-628	151	19	the	the	DET
admet-628	151	20	lung	lung	NOUN
admet-628	151	21	was	be	AUX
admet-628	151	22	lumped	lump	VERB
admet-628	151	23	into	into	ADP
admet-628	151	24	the	the	DET
admet-628	151	25	heart	heart	NOUN
admet-628	151	26	to	to	PART
admet-628	151	27	form	form	VERB
admet-628	151	28	the	the	DET
admet-628	151	29	“	"	PUNCT
admet-628	151	30	lung	lung	NOUN
admet-628	151	31	compartment	compartment	NOUN
admet-628	151	32	”	"	PUNCT
admet-628	151	33	;	;	PUNCT
admet-628	151	34	the	the	DET
admet-628	151	35	remaining	remain	VERB
admet-628	151	36	organs	organ	NOUN
admet-628	151	37	/	/	SYM
admet-628	151	38	tissues	tissue	NOUN
admet-628	151	39	including	include	VERB
admet-628	151	40	the	the	DET
admet-628	151	41	bone	bone	NOUN
admet-628	151	42	,	,	PUNCT
admet-628	151	43	skin	skin	NOUN
admet-628	151	44	,	,	PUNCT
admet-628	151	45	eye	eye	NOUN
admet-628	151	46	,	,	PUNCT
admet-628	151	47	etc	etc	X
admet-628	151	48	.	.	X
admet-628	151	49	,	,	PUNCT
admet-628	151	50	were	be	AUX
admet-628	151	51	grouped	group	VERB
admet-628	151	52	together	together	ADV
admet-628	151	53	to	to	PART
admet-628	151	54	form	form	VERB
admet-628	151	55	“	"	PUNCT
admet-628	151	56	the	the	DET
admet-628	151	57	rest	rest	NOUN
admet-628	151	58	of	of	ADP
admet-628	151	59	body	body	NOUN
admet-628	151	60	”	"	PUNCT
admet-628	151	61	.	.	PUNCT
admet-628	152	1	table	table	NOUN
admet-628	152	2	2	2	NUM
admet-628	152	3	.	.	PUNCT
admet-628	152	4	pharmacokinetic	pharmacokinetic	ADJ
admet-628	152	5	parameters	parameter	NOUN
admet-628	152	6	for	for	ADP
admet-628	152	7	the	the	DET
admet-628	152	8	op	op	NOUN
admet-628	152	9	pbpk	pbpk	PROPN
admet-628	152	10	model	model	NOUN
admet-628	152	11	of	of	ADP
admet-628	152	12	rats	rat	NOUN
admet-628	152	13	and	and	CCONJ
admet-628	152	14	humans	human	NOUN
admet-628	152	15	chemical	chemical	VERB
admet-628	152	16	specific	specific	ADJ
admet-628	152	17	parameters	parameter	NOUN
admet-628	152	18	molecular	molecular	ADJ
admet-628	152	19	weight	weight	NOUN
admet-628	152	20	oseltamivir	oseltamivir	NOUN
admet-628	152	21	phosphate	phosphate	VERB
admet-628	152	22	salt	salt	NOUN
admet-628	152	23	(	(	PUNCT
admet-628	152	24	op):410.4	op):410.4	PRON
admet-628	152	25	oseltamivir	oseltamivir	PROPN
admet-628	152	26	carboxylate	carboxylate	NOUN
admet-628	152	27	(	(	PUNCT
admet-628	152	28	oc	oc	PROPN
admet-628	152	29	):	):	PUNCT
admet-628	152	30	284.35	284.35	NUM
admet-628	152	31	used	use	VERB
admet-628	152	32	in	in	ADP
admet-628	152	33	model	model	NOUN
admet-628	152	34	unbound	unbound	NOUN
admet-628	152	35	fraction	fraction	NOUN
admet-628	152	36	in	in	ADP
admet-628	152	37	plasma	plasma	NOUN
admet-628	152	38	op	op	NOUN
admet-628	152	39	:	:	PUNCT
admet-628	152	40	53.7	53.7	NUM
admet-628	152	41	%	%	NOUN
admet-628	152	42	(	(	PUNCT
admet-628	152	43	rat	rat	NOUN
admet-628	152	44	)	)	PUNCT
admet-628	152	45	;	;	PUNCT
admet-628	152	46	57	57	NUM
admet-628	152	47	(	(	PUNCT
admet-628	152	48	human	human	NOUN
admet-628	152	49	)	)	PUNCT
admet-628	152	50	;	;	PUNCT
admet-628	152	51	oc	oc	ADP
admet-628	152	52	:	:	PUNCT
admet-628	152	53	no	no	DET
admet-628	152	54	data	datum	NOUN
admet-628	152	55	(	(	PUNCT
admet-628	152	56	rat	rat	NOUN
admet-628	152	57	)	)	PUNCT
admet-628	152	58	;	;	PUNCT
admet-628	152	59	97	97	NUM
admet-628	152	60	%	%	NOUN
admet-628	152	61	(	(	PUNCT
admet-628	152	62	human	human	NOUN
admet-628	152	63	)	)	PUNCT
admet-628	152	64	not	not	PART
admet-628	152	65	used	use	VERB
admet-628	152	66	in	in	ADP
admet-628	152	67	model	model	NOUN
admet-628	152	68	,	,	PUNCT
admet-628	152	69	for	for	ADP
admet-628	152	70	reference	reference	NOUN
admet-628	152	71	pk	pk	NOUN
admet-628	152	72	parameters	parameter	NOUN
admet-628	152	73	rat	rat	VERB
admet-628	152	74	human	human	ADJ
admet-628	152	75	parameter	parameter	NOUN
admet-628	152	76	experimental	experimental	ADJ
admet-628	152	77	optimized	optimize	VERB
admet-628	152	78	experimental	experimental	ADJ
admet-628	152	79	optimized	optimize	VERB
admet-628	152	80	f	f	PROPN
admet-628	152	81	0.35	0.35	NUM
admet-628	152	82	0.8	0.8	NUM
admet-628	152	83	-	-	SYM
admet-628	152	84	0.86	0.86	NUM
admet-628	152	85	0.75	0.75	NUM
admet-628	152	86	0.75	0.75	NUM
admet-628	152	87	tlag	tlag	NOUN
admet-628	152	88	(	(	PUNCT
admet-628	152	89	h	h	NOUN
admet-628	152	90	)	)	PUNCT
admet-628	152	91	na	na	ADP
admet-628	152	92	0.32	0.32	NUM
admet-628	152	93	-	-	SYM
admet-628	152	94	0.44	0.44	NUM
admet-628	152	95	na	na	NUM
admet-628	152	96	0.44	0.44	NUM
admet-628	152	97	ka	ka	X
admet-628	152	98	(	(	PUNCT
admet-628	152	99	1	1	NUM
admet-628	152	100	/	/	SYM
admet-628	152	101	h	h	NOUN
admet-628	152	102	)	)	PUNCT
admet-628	152	103	0.76	0.76	NUM
admet-628	152	104	12	12	NUM
admet-628	152	105	-	-	SYM
admet-628	152	106	15	15	NUM
admet-628	152	107	na	na	NOUN
admet-628	152	108	0.35	0.35	NUM
admet-628	152	109	(	(	PUNCT
admet-628	152	110	0.14	0.14	NUM
admet-628	152	111	-	-	SYM
admet-628	152	112	0.28	0.28	NUM
admet-628	152	113	)	)	PUNCT
admet-628	152	114	*	*	PUNCT
admet-628	153	1	*	*	PUNCT
admet-628	153	2	*	*	PUNCT
admet-628	153	3	blplrp	blplrp	NOUN
admet-628	153	4	1	1	NUM
admet-628	153	5	1	1	NUM
admet-628	153	6	na	na	PART
admet-628	153	7	1	1	NUM
admet-628	153	8	blplrc	blplrc	VERB
admet-628	153	9	1	1	NUM
admet-628	153	10	1	1	NUM
admet-628	153	11	(	(	PUNCT
admet-628	153	12	0.7	0.7	NUM
admet-628	153	13	)	)	PUNCT
admet-628	154	1	*	*	PUNCT
admet-628	154	2	*	*	PUNCT
admet-628	154	3	na	na	ADP
admet-628	154	4	1	1	NUM
admet-628	154	5	(	(	PUNCT
admet-628	154	6	0.6	0.6	NUM
admet-628	154	7	)	)	PUNCT
admet-628	154	8	*	*	PUNCT
admet-628	155	1	*	*	PUNCT
admet-628	155	2	clc	clc	PROPN
admet-628	155	3	(	(	PUNCT
admet-628	155	4	l	l	NOUN
admet-628	155	5	/	/	SYM
admet-628	155	6	h	h	NOUN
admet-628	155	7	)	)	PUNCT
admet-628	155	8	0.38	0.38	NUM
admet-628	155	9	0.38	0.38	NUM
admet-628	155	10	(	(	PUNCT
admet-628	155	11	0.5	0.5	NUM
admet-628	155	12	)	)	PUNCT
admet-628	155	13	*	*	PUNCT
admet-628	155	14	*	*	PUNCT
admet-628	155	15	18	18	NUM
admet-628	155	16	18(30	18(30	NUM
admet-628	155	17	)	)	PUNCT
admet-628	155	18	*	*	PUNCT
admet-628	155	19	*	*	PUNCT
admet-628	155	20	clp	clp	X
admet-628	155	21	(	(	PUNCT
admet-628	155	22	l	l	NOUN
admet-628	155	23	/	/	SYM
admet-628	155	24	h	h	NOUN
admet-628	155	25	)	)	PUNCT
admet-628	155	26	na	na	ADP
admet-628	155	27	0.4	0.4	NUM
admet-628	155	28	20	20	NUM
admet-628	155	29	100	100	NUM
admet-628	155	30	km	km	NOUN
admet-628	155	31	(	(	PUNCT
admet-628	155	32	mg	mg	PROPN
admet-628	155	33	/	/	SYM
admet-628	155	34	l	l	NOUN
admet-628	155	35	)	)	PUNCT
admet-628	155	36	300	300	NUM
admet-628	155	37	300	300	NUM
admet-628	155	38	76.0	76.0	NUM
admet-628	155	39	*	*	PUNCT
admet-628	155	40	*	*	PUNCT
admet-628	155	41	*	*	PUNCT
admet-628	155	42	*	*	PUNCT
admet-628	155	43	76.0	76.0	NUM
admet-628	155	44	*	*	PUNCT
admet-628	155	45	*	*	PUNCT
admet-628	155	46	*	*	PUNCT
admet-628	155	47	*	*	PUNCT
admet-628	155	48	vmax	vmax	X
admet-628	155	49	(	(	PUNCT
admet-628	155	50	mg	mg	PROPN
admet-628	155	51	/	/	SYM
admet-628	155	52	h	h	NOUN
admet-628	155	53	)	)	PUNCT
admet-628	155	54	*	*	NOUN
admet-628	155	55	61.2	61.2	NUM
admet-628	155	56	61.2	61.2	NUM
admet-628	155	57	2.6	2.6	NUM
admet-628	155	58	x	x	SYM
admet-628	155	59	10	10	NUM
admet-628	155	60	5	5	NUM
admet-628	155	61	*	*	PUNCT
admet-628	155	62	*	*	PUNCT
admet-628	155	63	*	*	PUNCT
admet-628	155	64	*	*	PUNCT
admet-628	155	65	2.6	2.6	NUM
admet-628	155	66	x	x	SYM
admet-628	155	67	10	10	NUM
admet-628	155	68	5	5	NUM
admet-628	155	69	*	*	PUNCT
admet-628	155	70	*	*	PUNCT
admet-628	155	71	*	*	PUNCT
admet-628	155	72	*	*	PUNCT
admet-628	155	73	*	*	PUNCT
admet-628	155	74	vmax	vmax	PROPN
admet-628	155	75	was	be	AUX
admet-628	155	76	based	base	VERB
admet-628	155	77	on	on	ADP
admet-628	155	78	a	a	DET
admet-628	155	79	0.25	0.25	NUM
admet-628	155	80	kg	kg	NOUN
admet-628	155	81	rat	rat	NOUN
admet-628	155	82	and	and	CCONJ
admet-628	155	83	a	a	DET
admet-628	155	84	70	70	NUM
admet-628	155	85	kg	kg	NOUN
admet-628	155	86	human	human	NOUN
admet-628	155	87	*	*	PROPN
admet-628	155	88	*	*	ADJ
admet-628	155	89	bracketed	bracketed	ADJ
admet-628	155	90	parameter	parameter	NOUN
admet-628	155	91	values	value	NOUN
admet-628	155	92	were	be	AUX
admet-628	155	93	used	use	VERB
admet-628	155	94	for	for	ADP
admet-628	155	95	the	the	DET
admet-628	155	96	i.v	i.v	PROPN
admet-628	155	97	.	.	PUNCT
admet-628	156	1	route	route	PROPN
admet-628	156	2	of	of	ADP
admet-628	156	3	administration	administration	NOUN
admet-628	156	4	*	*	PUNCT
admet-628	156	5	*	*	PUNCT
admet-628	156	6	*	*	PUNCT
admet-628	156	7	bracketed	bracketed	ADJ
admet-628	156	8	parameter	parameter	NOUN
admet-628	156	9	values	value	NOUN
admet-628	156	10	were	be	AUX
admet-628	156	11	used	use	VERB
admet-628	156	12	for	for	ADP
admet-628	156	13	multiple	multiple	ADJ
admet-628	156	14	oral	oral	ADJ
admet-628	156	15	administration	administration	NOUN
admet-628	156	16	;	;	PUNCT
admet-628	156	17	they	they	PRON
admet-628	156	18	were	be	AUX
admet-628	156	19	obtained	obtain	VERB
admet-628	156	20	by	by	ADP
admet-628	156	21	optimizing	optimize	VERB
admet-628	156	22	the	the	DET
admet-628	156	23	plasma	plasma	NOUN
admet-628	156	24	concentration	concentration	NOUN
admet-628	156	25	-	-	PUNCT
admet-628	156	26	time	time	NOUN
admet-628	156	27	data	datum	NOUN
admet-628	156	28	from	from	ADP
admet-628	156	29	he	he	PRON
admet-628	156	30	et	et	PROPN
admet-628	156	31	al	al	PROPN
admet-628	156	32	.	.	PUNCT
admet-628	157	1	[	[	X
admet-628	157	2	14	14	NUM
admet-628	157	3	]	]	PUNCT
admet-628	157	4	.	.	PUNCT
admet-628	158	1	*	*	PUNCT
admet-628	158	2	*	*	PUNCT
admet-628	158	3	*	*	PUNCT
admet-628	158	4	*	*	PUNCT
admet-628	158	5	shi	shi	PROPN
admet-628	158	6	et	et	PROPN
admet-628	158	7	al	al	PROPN
admet-628	159	1	[	[	X
admet-628	159	2	2	2	NUM
admet-628	159	3	]	]	PUNCT
admet-628	159	4	,	,	PUNCT
admet-628	159	5	km	km	PROPN
admet-628	159	6	=	=	NOUN
admet-628	159	7	187	187	NUM
admet-628	159	8	µm	µm	ADP
admet-628	159	9	and	and	CCONJ
admet-628	159	10	vmax=114	vmax=114	PROPN
admet-628	159	11	nmol	nmol	PROPN
admet-628	159	12	/	/	SYM
admet-628	159	13	mg	mg	PROPN
admet-628	159	14	/	/	SYM
admet-628	159	15	min	min	NOUN
admet-628	159	16	in	in	ADP
admet-628	159	17	this	this	DET
admet-628	159	18	paper	paper	NOUN
admet-628	159	19	,	,	PUNCT
admet-628	159	20	the	the	DET
admet-628	159	21	final	final	ADJ
admet-628	159	22	vmax	vmax	PROPN
admet-628	159	23	was	be	AUX
admet-628	159	24	calculated	calculate	VERB
admet-628	159	25	with	with	ADP
admet-628	159	26	70	70	NUM
admet-628	159	27	kg	kg	NOUN
admet-628	159	28	bw	bw	NOUN
admet-628	159	29	,	,	PUNCT
admet-628	159	30	1.8	1.8	NUM
admet-628	159	31	kg	kg	NOUN
admet-628	159	32	of	of	ADP
admet-628	159	33	liver	liver	NOUN
admet-628	159	34	weight	weight	NOUN
admet-628	159	35	and	and	CCONJ
admet-628	159	36	52.5	52.5	NUM
admet-628	159	37	mg	mg	NOUN
admet-628	159	38	microsomes	microsomes	PROPN
admet-628	159	39	/	/	SYM
admet-628	159	40	gram	gram	NOUN
admet-628	159	41	of	of	ADP
admet-628	159	42	liver	liver	NOUN
admet-628	159	43	for	for	ADP
admet-628	159	44	a	a	DET
admet-628	159	45	standard	standard	ADJ
admet-628	159	46	human	human	ADJ
admet-628	159	47	adult	adult	NOUN
admet-628	159	48	.	.	PUNCT
admet-628	160	1	na	na	NOUN
admet-628	160	2	:	:	PUNCT
admet-628	160	3	no	no	DET
admet-628	160	4	result	result	NOUN
admet-628	160	5	.	.	PUNCT
admet-628	161	1	g.	g.	PROPN
admet-628	161	2	gao	gao	PROPN
admet-628	161	3	et	et	PROPN
admet-628	161	4	al	al	PROPN
admet-628	161	5	.	.	PROPN
admet-628	161	6	admet	admet	PROPN
admet-628	161	7	&	&	CCONJ
admet-628	161	8	dmpk	dmpk	PROPN
admet-628	161	9	7(1	7(1	PROPN
admet-628	161	10	)	)	PUNCT
admet-628	161	11	(	(	PUNCT
admet-628	161	12	2019	2019	NUM
admet-628	161	13	)	)	PUNCT
admet-628	161	14	22	22	NUM
admet-628	161	15	-	-	SYM
admet-628	161	16	43	43	NUM
admet-628	161	17	28	28	NUM
admet-628	161	18	tissue	tissue	NOUN
admet-628	161	19	/	/	SYM
admet-628	161	20	plasma	plasma	NOUN
admet-628	161	21	partition	partition	NOUN
admet-628	161	22	coefficients	coefficient	NOUN
admet-628	161	23	.	.	PUNCT
admet-628	162	1	these	these	PRON
admet-628	162	2	were	be	AUX
admet-628	162	3	estimated	estimate	VERB
admet-628	162	4	by	by	ADP
admet-628	162	5	applying	apply	VERB
admet-628	162	6	the	the	DET
admet-628	162	7	area	area	NOUN
admet-628	162	8	method	method	NOUN
admet-628	162	9	of	of	ADP
admet-628	162	10	gallo	gallo	PROPN
admet-628	162	11	et	et	PROPN
admet-628	162	12	al	al	PROPN
admet-628	162	13	.	.	PUNCT
admet-628	163	1	[	[	X
admet-628	163	2	29	29	NUM
admet-628	163	3	]	]	PUNCT
admet-628	163	4	to	to	ADP
admet-628	163	5	the	the	DET
admet-628	163	6	experimental	experimental	ADJ
admet-628	163	7	data	datum	NOUN
admet-628	163	8	of	of	ADP
admet-628	163	9	rats	rat	NOUN
admet-628	163	10	after	after	ADP
admet-628	163	11	receiving	receive	VERB
admet-628	163	12	a	a	DET
admet-628	163	13	single	single	ADJ
admet-628	163	14	oral	oral	ADJ
admet-628	163	15	dose	dose	NOUN
admet-628	163	16	of	of	ADP
admet-628	163	17	10	10	NUM
admet-628	163	18	mg	mg	NUM
admet-628	163	19	/	/	SYM
admet-628	163	20	kg	kg	NOUN
admet-628	163	21	op	op	NOUN
admet-628	163	22	(	(	PUNCT
admet-628	163	23	table	table	NOUN
admet-628	163	24	1	1	NUM
admet-628	163	25	)	)	PUNCT
admet-628	163	26	.	.	PUNCT
admet-628	164	1	briefly	briefly	NOUN
admet-628	164	2	,	,	PUNCT
admet-628	164	3	the	the	DET
admet-628	164	4	experimental	experimental	ADJ
admet-628	164	5	op	op	NOUN
admet-628	164	6	/	/	SYM
admet-628	164	7	oc	oc	NOUN
admet-628	164	8	concentration	concentration	NOUN
admet-628	164	9	-	-	PUNCT
admet-628	164	10	time	time	NOUN
admet-628	164	11	curves	curve	NOUN
admet-628	164	12	in	in	ADP
admet-628	164	13	the	the	DET
admet-628	164	14	plasma	plasma	NOUN
admet-628	164	15	and	and	CCONJ
admet-628	164	16	organ	organ	NOUN
admet-628	164	17	/	/	SYM
admet-628	164	18	tissue	tissue	NOUN
admet-628	164	19	were	be	AUX
admet-628	164	20	analyzed	analyze	VERB
admet-628	164	21	separately	separately	ADV
admet-628	164	22	with	with	ADP
admet-628	164	23	the	the	DET
admet-628	164	24	non	non	ADJ
admet-628	164	25	-	-	ADJ
admet-628	164	26	compartmental	compartmental	ADJ
admet-628	164	27	approach	approach	NOUN
admet-628	164	28	(	(	PUNCT
admet-628	164	29	winnonlin	winnonlin	PROPN
admet-628	164	30	®	®	NOUN
admet-628	164	31	,	,	PUNCT
admet-628	164	32	scientific	scientific	ADJ
admet-628	164	33	consulting	consulting	NOUN
admet-628	164	34	,	,	PUNCT
admet-628	164	35	inc	inc	PROPN
admet-628	164	36	.	.	PROPN
admet-628	164	37	version	version	PROPN
admet-628	164	38	1.5	1.5	NUM
admet-628	164	39	)	)	PUNCT
admet-628	164	40	to	to	PART
admet-628	164	41	obtain	obtain	VERB
admet-628	164	42	the	the	DET
admet-628	164	43	area	area	NOUN
admet-628	164	44	under	under	ADP
admet-628	164	45	the	the	DET
admet-628	164	46	concentration	concentration	NOUN
admet-628	164	47	-	-	PUNCT
admet-628	164	48	time	time	NOUN
admet-628	164	49	curve	curve	NOUN
admet-628	164	50	(	(	PUNCT
admet-628	164	51	auc	auc	NOUN
admet-628	164	52	)	)	PUNCT
admet-628	164	53	.	.	PUNCT
admet-628	165	1	the	the	DET
admet-628	165	2	in	in	ADP
admet-628	165	3	vivo	vivo	ADJ
admet-628	165	4	tissue	tissue	NOUN
admet-628	165	5	/	/	SYM
admet-628	165	6	plasma	plasma	NOUN
admet-628	165	7	partition	partition	NOUN
admet-628	165	8	coefficient	coefficient	NOUN
admet-628	165	9	for	for	ADP
admet-628	165	10	a	a	DET
admet-628	165	11	specific	specific	ADJ
admet-628	165	12	organ	organ	NOUN
admet-628	165	13	was	be	AUX
admet-628	165	14	estimated	estimate	VERB
admet-628	165	15	from	from	ADP
admet-628	165	16	the	the	DET
admet-628	165	17	auctissue	auctissue	NOUN
admet-628	165	18	/	/	SYM
admet-628	165	19	aucplasma	aucplasma	PROPN
admet-628	165	20	ratio	ratio	NOUN
admet-628	165	21	,	,	PUNCT
admet-628	165	22	table	table	NOUN
admet-628	165	23	1	1	NUM
admet-628	165	24	,	,	PUNCT
admet-628	165	25	lists	list	VERB
admet-628	165	26	the	the	DET
admet-628	165	27	final	final	ADJ
admet-628	165	28	tissue	tissue	NOUN
admet-628	165	29	/	/	SYM
admet-628	165	30	plasma	plasma	NOUN
admet-628	165	31	partitioning	partitioning	NOUN
admet-628	165	32	coefficients	coefficient	NOUN
admet-628	165	33	which	which	PRON
admet-628	165	34	had	have	AUX
admet-628	165	35	been	be	AUX
admet-628	165	36	adjusted	adjust	VERB
admet-628	165	37	to	to	PART
admet-628	165	38	available	available	VERB
admet-628	165	39	experimental	experimental	ADJ
admet-628	165	40	data	datum	NOUN
admet-628	165	41	.	.	PUNCT
admet-628	166	1	in	in	ADP
admet-628	166	2	rat	rat	NOUN
admet-628	166	3	,	,	PUNCT
admet-628	166	4	plasma	plasma	NOUN
admet-628	166	5	protein	protein	NOUN
admet-628	166	6	binding	bind	VERB
admet-628	166	7	for	for	ADP
admet-628	166	8	op	op	NOUN
admet-628	166	9	was	be	AUX
admet-628	166	10	reported	report	VERB
admet-628	166	11	to	to	PART
admet-628	166	12	be	be	AUX
admet-628	166	13	53.7	53.7	NUM
admet-628	166	14	%	%	NOUN
admet-628	167	1	[	[	X
admet-628	167	2	30	30	NUM
admet-628	167	3	]	]	PUNCT
admet-628	167	4	,	,	PUNCT
admet-628	167	5	similar	similar	ADJ
admet-628	167	6	binding	binding	ADJ
admet-628	167	7	capacity	capacity	NOUN
admet-628	167	8	in	in	ADP
admet-628	167	9	blood	blood	NOUN
admet-628	167	10	as	as	ADP
admet-628	167	11	in	in	ADP
admet-628	167	12	plasma	plasma	NOUN
admet-628	167	13	was	be	AUX
admet-628	167	14	found	find	VERB
admet-628	167	15	in	in	ADP
admet-628	167	16	our	our	PRON
admet-628	167	17	study	study	NOUN
admet-628	167	18	for	for	ADP
admet-628	167	19	both	both	DET
admet-628	167	20	op	op	NOUN
admet-628	167	21	and	and	CCONJ
admet-628	167	22	oc	oc	NOUN
admet-628	167	23	.	.	PUNCT
admet-628	168	1	the	the	DET
admet-628	168	2	tissue	tissue	NOUN
admet-628	168	3	/	/	SYM
admet-628	168	4	plasma	plasma	NOUN
admet-628	168	5	partition	partition	NOUN
admet-628	168	6	coefficients	coefficient	NOUN
admet-628	168	7	basically	basically	ADV
admet-628	168	8	agreed	agree	VERB
admet-628	168	9	with	with	ADP
admet-628	168	10	the	the	DET
admet-628	168	11	lipid	lipid	ADJ
admet-628	168	12	contents	content	NOUN
admet-628	168	13	of	of	ADP
admet-628	168	14	the	the	DET
admet-628	168	15	tissues	tissue	NOUN
admet-628	168	16	and	and	CCONJ
admet-628	168	17	the	the	DET
admet-628	168	18	lipid	lipid	NOUN
admet-628	168	19	solubility	solubility	NOUN
admet-628	168	20	of	of	ADP
admet-628	168	21	op	op	NOUN
admet-628	168	22	or	or	CCONJ
admet-628	168	23	oc	oc	PROPN
admet-628	168	24	.	.	PROPN
admet-628	168	25	model	model	PROPN
admet-628	168	26	simulation	simulation	PROPN
admet-628	168	27	.	.	PUNCT
admet-628	169	1	the	the	DET
admet-628	169	2	differential	differential	ADJ
admet-628	169	3	and	and	CCONJ
admet-628	169	4	algebraic	algebraic	ADJ
admet-628	169	5	equations	equation	NOUN
admet-628	169	6	describing	describe	VERB
admet-628	169	7	the	the	DET
admet-628	169	8	movement	movement	NOUN
admet-628	169	9	of	of	ADP
admet-628	169	10	op	op	NOUN
admet-628	169	11	and	and	CCONJ
admet-628	169	12	oc	oc	VERB
admet-628	169	13	through	through	ADP
admet-628	169	14	the	the	DET
admet-628	169	15	rat	rat	NOUN
admet-628	169	16	or	or	CCONJ
admet-628	169	17	human	human	NOUN
admet-628	169	18	were	be	AUX
admet-628	169	19	formulated	formulate	VERB
admet-628	169	20	as	as	ADP
admet-628	169	21	a	a	DET
admet-628	169	22	computer	computer	NOUN
admet-628	169	23	program	program	NOUN
admet-628	169	24	.	.	PUNCT
admet-628	170	1	mass	mass	PROPN
admet-628	170	2	balance	balance	NOUN
admet-628	170	3	differential	differential	NOUN
admet-628	170	4	equations	equation	NOUN
admet-628	170	5	for	for	ADP
admet-628	170	6	the	the	DET
admet-628	170	7	model	model	NOUN
admet-628	170	8	and	and	CCONJ
admet-628	170	9	the	the	DET
admet-628	170	10	definition	definition	NOUN
admet-628	170	11	of	of	ADP
admet-628	170	12	the	the	DET
admet-628	170	13	algebraic	algebraic	ADJ
admet-628	170	14	terms	term	NOUN
admet-628	170	15	are	be	AUX
admet-628	170	16	given	give	VERB
admet-628	170	17	as	as	ADP
admet-628	170	18	parts	part	NOUN
admet-628	170	19	of	of	ADP
admet-628	170	20	the	the	DET
admet-628	170	21	model	model	NOUN
admet-628	170	22	structure	structure	NOUN
admet-628	170	23	(	(	PUNCT
admet-628	170	24	fig	fig	NOUN
admet-628	170	25	.	.	NOUN
admet-628	170	26	1	1	NUM
admet-628	170	27	and	and	CCONJ
admet-628	170	28	appendix	appendix	NOUN
admet-628	170	29	)	)	PUNCT
admet-628	170	30	.	.	PUNCT
admet-628	171	1	after	after	ADP
admet-628	171	2	incorporating	incorporate	VERB
admet-628	171	3	the	the	DET
admet-628	171	4	parameter	parameter	NOUN
admet-628	171	5	values	value	NOUN
admet-628	171	6	(	(	PUNCT
admet-628	171	7	tables	table	NOUN
admet-628	171	8	1	1	NUM
admet-628	171	9	and	and	CCONJ
admet-628	171	10	2	2	NUM
admet-628	171	11	)	)	PUNCT
admet-628	171	12	into	into	ADP
admet-628	171	13	the	the	DET
admet-628	171	14	model	model	NOUN
admet-628	171	15	(	(	PUNCT
admet-628	171	16	fig	fig	NOUN
admet-628	171	17	.	.	NOUN
admet-628	171	18	1	1	NUM
admet-628	171	19	)	)	PUNCT
admet-628	171	20	,	,	PUNCT
admet-628	171	21	the	the	DET
admet-628	171	22	differential	differential	ADJ
admet-628	171	23	and	and	CCONJ
admet-628	171	24	algebraic	algebraic	ADJ
admet-628	171	25	equations	equation	NOUN
admet-628	171	26	were	be	AUX
admet-628	171	27	solved	solve	VERB
admet-628	171	28	numerically	numerically	ADV
admet-628	171	29	with	with	ADP
admet-628	171	30	the	the	DET
admet-628	171	31	aid	aid	NOUN
admet-628	171	32	of	of	ADP
admet-628	171	33	acslxtreme	acslxtreme	NOUN
admet-628	171	34	®	®	PROPN
admet-628	171	35	2.4.2.1	2.4.2.1	NUM
admet-628	171	36	(	(	PUNCT
admet-628	171	37	aegis	aegis	PROPN
admet-628	171	38	technologies	technology	NOUN
admet-628	171	39	group	group	PROPN
admet-628	171	40	,	,	PUNCT
admet-628	171	41	inc	inc	PROPN
admet-628	171	42	.	.	PROPN
admet-628	171	43	,	,	PUNCT
admet-628	171	44	huntsville	huntsville	PROPN
admet-628	171	45	,	,	PUNCT
admet-628	171	46	al	al	PROPN
admet-628	171	47	)	)	PUNCT
admet-628	171	48	.	.	PUNCT
admet-628	172	1	an	an	DET
admet-628	172	2	i.v	i.v	PROPN
admet-628	172	3	.	.	PUNCT
admet-628	172	4	injection	injection	NOUN
admet-628	172	5	function	function	NOUN
admet-628	172	6	instead	instead	ADV
admet-628	172	7	of	of	ADP
admet-628	172	8	oral	oral	ADJ
admet-628	172	9	absorption	absorption	NOUN
admet-628	172	10	was	be	AUX
admet-628	172	11	used	use	VERB
admet-628	172	12	to	to	PART
admet-628	172	13	drive	drive	VERB
admet-628	172	14	the	the	DET
admet-628	172	15	model	model	NOUN
admet-628	172	16	when	when	SCONJ
admet-628	172	17	op	op	NOUN
admet-628	172	18	/	/	SYM
admet-628	172	19	oc	oc	NOUN
admet-628	172	20	was	be	AUX
admet-628	172	21	administered	administer	VERB
admet-628	172	22	intravenously	intravenously	ADV
admet-628	172	23	[	[	X
admet-628	172	24	31	31	NUM
admet-628	172	25	]	]	PUNCT
admet-628	172	26	.	.	PUNCT
admet-628	173	1	scaling	scale	VERB
admet-628	173	2	up	up	ADP
admet-628	173	3	of	of	ADP
admet-628	173	4	rat	rat	NOUN
admet-628	173	5	pbpk	pbpk	NOUN
admet-628	173	6	models	model	NOUN
admet-628	173	7	to	to	ADP
admet-628	173	8	humans	human	NOUN
admet-628	173	9	.	.	PUNCT
admet-628	174	1	the	the	DET
admet-628	174	2	rat	rat	NOUN
admet-628	174	3	model	model	NOUN
admet-628	174	4	(	(	PUNCT
admet-628	174	5	fig	fig	NOUN
admet-628	174	6	.	.	PUNCT
admet-628	174	7	2	2	NUM
admet-628	174	8	)	)	PUNCT
admet-628	174	9	was	be	AUX
admet-628	174	10	scaled	scale	VERB
admet-628	174	11	up	up	ADP
admet-628	174	12	to	to	ADP
admet-628	174	13	humans	human	NOUN
admet-628	174	14	by	by	ADP
admet-628	174	15	replacing	replace	VERB
admet-628	174	16	the	the	DET
admet-628	174	17	physiological	physiological	ADJ
admet-628	174	18	parameters	parameter	NOUN
admet-628	174	19	and	and	CCONJ
admet-628	174	20	pharmacokinetic	pharmacokinetic	ADJ
admet-628	174	21	parameters	parameter	NOUN
admet-628	174	22	in	in	ADP
admet-628	174	23	the	the	DET
admet-628	174	24	rat	rat	NOUN
admet-628	174	25	model	model	NOUN
admet-628	174	26	with	with	ADP
admet-628	174	27	human	human	ADJ
admet-628	174	28	specific	specific	ADJ
admet-628	174	29	values	value	NOUN
admet-628	174	30	(	(	PUNCT
admet-628	174	31	table	table	NOUN
admet-628	174	32	1	1	NUM
admet-628	174	33	)	)	PUNCT
admet-628	174	34	.	.	PUNCT
admet-628	175	1	the	the	DET
admet-628	175	2	human	human	ADJ
admet-628	175	3	pbpk	pbpk	PROPN
admet-628	175	4	model	model	NOUN
admet-628	175	5	was	be	AUX
admet-628	175	6	parameterized	parameterized	ADJ
admet-628	175	7	as	as	SCONJ
admet-628	175	8	follows	follow	VERB
admet-628	175	9	:	:	PUNCT
admet-628	175	10	(	(	PUNCT
admet-628	175	11	a	a	X
admet-628	175	12	)	)	PUNCT
admet-628	175	13	tissue	tissue	NOUN
admet-628	175	14	volumes	volume	NOUN
admet-628	175	15	and	and	CCONJ
admet-628	175	16	blood	blood	NOUN
admet-628	175	17	flows	flow	NOUN
admet-628	175	18	to	to	ADP
admet-628	175	19	tissues	tissue	NOUN
admet-628	175	20	were	be	AUX
admet-628	175	21	taken	take	VERB
admet-628	175	22	from	from	ADP
admet-628	175	23	the	the	DET
admet-628	175	24	literature	literature	NOUN
admet-628	175	25	[	[	X
admet-628	175	26	25,26	25,26	NUM
admet-628	175	27	]	]	PUNCT
admet-628	175	28	,	,	PUNCT
admet-628	175	29	(	(	PUNCT
admet-628	175	30	b	b	NOUN
admet-628	175	31	)	)	PUNCT
admet-628	175	32	tissue	tissue	NOUN
admet-628	175	33	/	/	SYM
admet-628	175	34	plasma	plasma	NOUN
admet-628	175	35	partitioning	partitioning	NOUN
admet-628	175	36	coefficients	coefficient	NOUN
admet-628	175	37	were	be	AUX
admet-628	175	38	assumed	assume	VERB
admet-628	175	39	to	to	PART
admet-628	175	40	be	be	AUX
admet-628	175	41	the	the	DET
admet-628	175	42	same	same	ADJ
admet-628	175	43	as	as	ADP
admet-628	175	44	those	those	PRON
admet-628	175	45	of	of	ADP
admet-628	175	46	rats	rat	NOUN
admet-628	175	47	,	,	PUNCT
admet-628	175	48	(	(	PUNCT
admet-628	175	49	c	c	X
admet-628	175	50	)	)	PUNCT
admet-628	175	51	f	f	PROPN
admet-628	175	52	was	be	AUX
admet-628	175	53	set	set	VERB
admet-628	175	54	to	to	ADP
admet-628	175	55	75	75	NUM
admet-628	175	56	%	%	NOUN
admet-628	175	57	based	base	VERB
admet-628	175	58	on	on	ADP
admet-628	175	59	the	the	DET
admet-628	175	60	absolute	absolute	ADJ
admet-628	175	61	bioavailability	bioavailability	NOUN
admet-628	175	62	reported	report	VERB
admet-628	175	63	in	in	ADP
admet-628	175	64	humans	human	NOUN
admet-628	175	65	[	[	X
admet-628	175	66	14,32	14,32	NUM
admet-628	175	67	]	]	PUNCT
admet-628	175	68	,	,	PUNCT
admet-628	175	69	(	(	PUNCT
admet-628	175	70	d	d	X
admet-628	175	71	)	)	PUNCT
admet-628	175	72	plasma	plasma	NOUN
admet-628	175	73	protein	protein	NOUN
admet-628	175	74	binding	bind	VERB
admet-628	175	75	of	of	ADP
admet-628	175	76	oc	oc	NOUN
admet-628	175	77	and	and	CCONJ
admet-628	175	78	op	op	NOUN
admet-628	175	79	in	in	ADP
admet-628	175	80	humans	human	NOUN
admet-628	175	81	was	be	AUX
admet-628	175	82	3	3	NUM
admet-628	175	83	%	%	NOUN
admet-628	175	84	and	and	CCONJ
admet-628	175	85	43	43	NUM
admet-628	175	86	%	%	NOUN
admet-628	175	87	,	,	PUNCT
admet-628	175	88	respectively	respectively	ADV
admet-628	175	89	[	[	X
admet-628	175	90	4	4	NUM
admet-628	175	91	]	]	PUNCT
admet-628	175	92	,	,	PUNCT
admet-628	175	93	(	(	PUNCT
admet-628	175	94	d	d	X
admet-628	175	95	)	)	PUNCT
admet-628	175	96	gut	gut	NOUN
admet-628	175	97	content	content	NOUN
admet-628	175	98	volumes	volume	NOUN
admet-628	175	99	was	be	AUX
admet-628	175	100	scaled	scale	VERB
admet-628	175	101	based	base	VERB
admet-628	175	102	on	on	ADP
admet-628	175	103	the	the	DET
admet-628	175	104	body	body	NOUN
admet-628	175	105	weights	weight	NOUN
admet-628	175	106	of	of	ADP
admet-628	175	107	rats	rat	NOUN
admet-628	175	108	and	and	CCONJ
admet-628	175	109	humans	human	NOUN
admet-628	175	110	;	;	PUNCT
admet-628	175	111	the	the	DET
admet-628	175	112	gut	gut	NOUN
admet-628	175	113	content	content	NOUN
admet-628	175	114	of	of	ADP
admet-628	175	115	a	a	DET
admet-628	175	116	70	70	NUM
admet-628	175	117	kg	kg	NOUN
admet-628	175	118	human	human	NOUN
admet-628	175	119	was	be	AUX
admet-628	175	120	determined	determined	ADJ
admet-628	175	121	to	to	PART
admet-628	175	122	be	be	AUX
admet-628	175	123	0.16	0.16	NUM
admet-628	175	124	l	l	NOUN
admet-628	176	1	[	[	X
admet-628	176	2	26	26	NUM
admet-628	176	3	]	]	PUNCT
admet-628	176	4	,	,	PUNCT
admet-628	176	5	(	(	PUNCT
admet-628	176	6	e	e	NOUN
admet-628	176	7	)	)	PUNCT
admet-628	176	8	clearance	clearance	NOUN
admet-628	176	9	of	of	ADP
admet-628	176	10	oc	oc	PROPN
admet-628	176	11	(	(	PUNCT
admet-628	176	12	clc	clc	PROPN
admet-628	176	13	)	)	PUNCT
admet-628	176	14	in	in	ADP
admet-628	176	15	urine	urine	NOUN
admet-628	176	16	was	be	AUX
admet-628	176	17	reported	report	VERB
admet-628	176	18	to	to	PART
admet-628	176	19	be	be	AUX
admet-628	176	20	18	18	NUM
admet-628	176	21	l	l	NOUN
admet-628	176	22	/	/	SYM
admet-628	176	23	h	h	NOUN
admet-628	177	1	[	[	X
admet-628	177	2	14,33	14,33	NUM
admet-628	177	3	]	]	PUNCT
admet-628	177	4	.	.	PUNCT
admet-628	178	1	clearance	clearance	NOUN
admet-628	178	2	value	value	NOUN
admet-628	178	3	for	for	ADP
admet-628	178	4	op	op	NOUN
admet-628	178	5	(	(	PUNCT
admet-628	178	6	clp	clp	PROPN
admet-628	178	7	)	)	PUNCT
admet-628	178	8	was	be	AUX
admet-628	178	9	scaled	scale	VERB
admet-628	178	10	from	from	ADP
admet-628	178	11	the	the	DET
admet-628	178	12	clearance	clearance	NOUN
admet-628	178	13	of	of	ADP
admet-628	178	14	rats	rat	NOUN
admet-628	178	15	using	use	VERB
admet-628	178	16	the	the	DET
admet-628	178	17	allometric	allometric	ADJ
admet-628	178	18	equation	equation	NOUN
admet-628	178	19	,	,	PUNCT
admet-628	178	20	clbc	clbc	PROPN
admet-628	178	21	=	=	SYM
admet-628	178	22	clb/(bw	clb/(bw	PROPN
admet-628	178	23	)	)	PUNCT
admet-628	178	24	0.66	0.66	NUM
admet-628	179	1	[	[	X
admet-628	179	2	34	34	NUM
admet-628	179	3	]	]	PUNCT
admet-628	179	4	initially	initially	ADV
admet-628	179	5	,	,	PUNCT
admet-628	179	6	it	it	PRON
admet-628	179	7	was	be	AUX
admet-628	179	8	reported	report	VERB
admet-628	179	9	to	to	PART
admet-628	179	10	be	be	AUX
admet-628	179	11	20	20	NUM
admet-628	179	12	l	l	NOUN
admet-628	179	13	/	/	SYM
admet-628	179	14	h	h	NOUN
admet-628	179	15	while	while	SCONJ
admet-628	179	16	cl	cl	NOUN
admet-628	179	17	/	/	SYM
admet-628	179	18	f	f	PROPN
admet-628	179	19	was	be	AUX
admet-628	179	20	0.438	0.438	NUM
admet-628	179	21	l	l	NOUN
admet-628	179	22	/	/	SYM
admet-628	179	23	min	min	NOUN
admet-628	180	1	[	[	X
admet-628	180	2	14	14	NUM
admet-628	180	3	]	]	PUNCT
admet-628	180	4	,	,	PUNCT
admet-628	180	5	considering	consider	VERB
admet-628	180	6	the	the	DET
admet-628	180	7	uncertainty	uncertainty	NOUN
admet-628	180	8	of	of	ADP
admet-628	180	9	absorption	absorption	NOUN
admet-628	180	10	parameters	parameter	NOUN
admet-628	180	11	and	and	CCONJ
admet-628	180	12	the	the	DET
admet-628	180	13	difference	difference	NOUN
admet-628	180	14	between	between	ADP
admet-628	180	15	classical	classical	ADJ
admet-628	180	16	model	model	NOUN
admet-628	180	17	and	and	CCONJ
admet-628	180	18	pbpk	pbpk	NOUN
admet-628	180	19	model	model	NOUN
admet-628	180	20	,	,	PUNCT
admet-628	180	21	clp	clp	PROPN
admet-628	180	22	was	be	AUX
admet-628	180	23	allowed	allow	VERB
admet-628	180	24	to	to	PART
admet-628	180	25	be	be	AUX
admet-628	180	26	optimized	optimize	VERB
admet-628	180	27	using	use	VERB
admet-628	180	28	the	the	DET
admet-628	180	29	plasma	plasma	NOUN
admet-628	180	30	concentration	concentration	NOUN
admet-628	180	31	-	-	PUNCT
admet-628	180	32	time	time	NOUN
admet-628	180	33	curve	curve	NOUN
admet-628	180	34	reported	report	VERB
admet-628	180	35	by	by	ADP
admet-628	180	36	he	he	PRON
admet-628	180	37	et	et	PROPN
admet-628	180	38	al	al	PROPN
admet-628	180	39	.	.	PUNCT
admet-628	181	1	[	[	X
admet-628	181	2	14	14	NUM
admet-628	181	3	]	]	PUNCT
admet-628	181	4	,	,	PUNCT
admet-628	181	5	(	(	PUNCT
admet-628	181	6	f	f	X
admet-628	181	7	)	)	PUNCT
admet-628	181	8	in	in	ADP
admet-628	181	9	vitro	vitro	X
admet-628	181	10	km	km	PROPN
admet-628	181	11	and	and	CCONJ
admet-628	181	12	vmax	vmax	PROPN
admet-628	181	13	of	of	ADP
admet-628	181	14	op	op	NOUN
admet-628	181	15	metabolism	metabolism	NOUN
admet-628	181	16	in	in	ADP
admet-628	181	17	human	human	ADJ
admet-628	181	18	liver	liver	NOUN
admet-628	181	19	microsomal	microsomal	ADJ
admet-628	181	20	incubates	incubate	NOUN
admet-628	181	21	were	be	AUX
admet-628	181	22	reported	report	VERB
admet-628	181	23	to	to	PART
admet-628	181	24	be	be	AUX
admet-628	181	25	187	187	NUM
admet-628	181	26	µm	µm	ADP
admet-628	181	27	and	and	CCONJ
admet-628	181	28	114	114	NUM
admet-628	181	29	nmol	nmol	NOUN
admet-628	181	30	/	/	SYM
admet-628	181	31	mg	mg	PROPN
admet-628	181	32	/	/	SYM
admet-628	181	33	min	min	NOUN
admet-628	181	34	,	,	PUNCT
admet-628	181	35	respectively	respectively	ADV
admet-628	181	36	[	[	X
admet-628	181	37	2	2	NUM
admet-628	181	38	]	]	PUNCT
admet-628	181	39	;	;	PUNCT
admet-628	181	40	these	these	PRON
admet-628	181	41	translated	translate	VERB
admet-628	181	42	into	into	ADP
admet-628	181	43	in	in	ADP
admet-628	181	44	vivo	vivo	ADJ
admet-628	181	45	km	km	NOUN
admet-628	181	46	and	and	CCONJ
admet-628	181	47	vmax	vmax	PROPN
admet-628	181	48	values	value	NOUN
admet-628	181	49	of	of	ADP
admet-628	181	50	76	76	NUM
admet-628	181	51	mg	mg	PROPN
admet-628	181	52	/	/	SYM
admet-628	181	53	l	l	NOUN
admet-628	181	54	and	and	CCONJ
admet-628	181	55	about	about	ADP
admet-628	181	56	2.6x105	2.6x105	ADJ
admet-628	181	57	mg	mg	PROPN
admet-628	181	58	/	/	SYM
admet-628	181	59	h	h	NOUN
admet-628	181	60	,	,	PUNCT
admet-628	181	61	respectively	respectively	ADV
admet-628	181	62	for	for	ADP
admet-628	181	63	humans	human	NOUN
admet-628	181	64	based	base	VERB
admet-628	181	65	on	on	ADP
admet-628	181	66	an	an	DET
admet-628	181	67	average	average	ADJ
admet-628	181	68	microsomal	microsomal	ADJ
admet-628	181	69	yield	yield	NOUN
admet-628	181	70	of	of	ADP
admet-628	181	71	52.5	52.5	NUM
admet-628	181	72	mg	mg	ADJ
admet-628	181	73	microsomal	microsomal	ADJ
admet-628	181	74	proteins	protein	NOUN
admet-628	181	75	per	per	ADP
admet-628	181	76	g	g	NOUN
admet-628	181	77	liver	liver	NOUN
admet-628	181	78	[	[	X
admet-628	181	79	14,31,35	14,31,35	NUM
admet-628	181	80	]	]	PUNCT
admet-628	181	81	,	,	PUNCT
admet-628	181	82	and	and	CCONJ
admet-628	181	83	(	(	PUNCT
admet-628	181	84	g	g	NOUN
admet-628	181	85	)	)	PUNCT
admet-628	181	86	ka	ka	PROPN
admet-628	181	87	and	and	CCONJ
admet-628	181	88	kf	kf	PROPN
admet-628	181	89	rate	rate	NOUN
admet-628	181	90	constants	constant	NOUN
admet-628	181	91	(	(	PUNCT
admet-628	181	92	table	table	NOUN
admet-628	181	93	2	2	NUM
admet-628	181	94	)	)	PUNCT
admet-628	181	95	were	be	AUX
admet-628	181	96	scaled	scale	VERB
admet-628	181	97	up	up	ADP
admet-628	181	98	from	from	ADP
admet-628	181	99	rats	rat	NOUN
admet-628	181	100	using	use	VERB
admet-628	181	101	the	the	DET
admet-628	181	102	equation	equation	NOUN
admet-628	181	103	,	,	PUNCT
admet-628	181	104	kc	kc	PROPN
admet-628	181	105	=	=	PROPN
admet-628	181	106	ka/(bw)-0.3	ka/(bw)-0.3	PROPN
admet-628	181	107	,	,	PUNCT
admet-628	181	108	where	where	SCONJ
admet-628	181	109	ka	ka	PROPN
admet-628	181	110	represented	represent	VERB
admet-628	181	111	the	the	DET
admet-628	181	112	rate	rate	NOUN
admet-628	181	113	constant	constant	ADJ
admet-628	181	114	,	,	PUNCT
admet-628	181	115	kc	kc	PROPN
admet-628	181	116	represented	represent	VERB
admet-628	181	117	the	the	DET
admet-628	181	118	scaling	scaling	ADJ
admet-628	181	119	coefficient	coefficient	NOUN
admet-628	181	120	and	and	CCONJ
admet-628	181	121	bw	bw	PROPN
admet-628	181	122	was	be	AUX
admet-628	181	123	the	the	DET
admet-628	181	124	average	average	ADJ
admet-628	181	125	body	body	NOUN
admet-628	181	126	weight	weight	NOUN
admet-628	181	127	of	of	ADP
admet-628	181	128	human	human	ADJ
admet-628	181	129	volunteers	volunteer	NOUN
admet-628	182	1	[	[	X
admet-628	182	2	36	36	NUM
admet-628	182	3	]	]	PUNCT
admet-628	182	4	.	.	PUNCT
admet-628	183	1	model	model	NOUN
admet-628	183	2	parameters	parameter	NOUN
admet-628	183	3	that	that	PRON
admet-628	183	4	could	could	AUX
admet-628	183	5	not	not	PART
admet-628	183	6	be	be	AUX
admet-628	183	7	parameterized	parameterize	VERB
admet-628	183	8	a	a	DET
admet-628	183	9	priori	priori	ADV
admet-628	183	10	were	be	AUX
admet-628	183	11	optimized	optimize	VERB
admet-628	183	12	by	by	ADP
admet-628	183	13	fitting	fit	VERB
admet-628	183	14	the	the	DET
admet-628	183	15	pbpk	pbpk	ADJ
admet-628	183	16	model	model	NOUN
admet-628	183	17	to	to	PART
admet-628	183	18	available	available	VERB
admet-628	183	19	experimental	experimental	ADJ
admet-628	183	20	data	datum	NOUN
admet-628	183	21	(	(	PUNCT
admet-628	183	22	see	see	VERB
admet-628	183	23	data	datum	NOUN
admet-628	183	24	fitting	fitting	ADJ
admet-628	183	25	below	below	ADP
admet-628	183	26	)	)	PUNCT
admet-628	183	27	.	.	PUNCT
admet-628	184	1	final	final	ADJ
admet-628	184	2	parameter	parameter	NOUN
admet-628	184	3	values	value	NOUN
admet-628	184	4	used	use	VERB
admet-628	184	5	to	to	PART
admet-628	184	6	implement	implement	VERB
admet-628	184	7	the	the	DET
admet-628	184	8	human	human	ADJ
admet-628	184	9	pbpk	pbpk	NOUN
admet-628	184	10	model	model	NOUN
admet-628	184	11	are	be	AUX
admet-628	184	12	listed	list	VERB
admet-628	184	13	in	in	ADP
admet-628	184	14	table	table	NOUN
admet-628	184	15	3	3	NUM
admet-628	184	16	.	.	PUNCT
admet-628	184	17	data	datum	NOUN
admet-628	184	18	fitting	fitting	ADJ
admet-628	184	19	and	and	CCONJ
admet-628	184	20	parameter	parameter	NOUN
admet-628	184	21	optimization	optimization	NOUN
admet-628	184	22	.	.	PUNCT
admet-628	185	1	the	the	DET
admet-628	185	2	parameters	parameter	NOUN
admet-628	185	3	that	that	PRON
admet-628	185	4	could	could	AUX
admet-628	185	5	not	not	PART
admet-628	185	6	be	be	AUX
admet-628	185	7	obtained	obtain	VERB
admet-628	185	8	a	a	DET
admet-628	185	9	priori	priori	NOUN
admet-628	185	10	or	or	CCONJ
admet-628	185	11	determined	determine	VERB
admet-628	185	12	accurately	accurately	ADV
admet-628	185	13	were	be	AUX
admet-628	185	14	optimized	optimize	VERB
admet-628	185	15	by	by	ADP
admet-628	185	16	fitting	fit	VERB
admet-628	185	17	the	the	DET
admet-628	185	18	pbpk	pbpk	ADJ
admet-628	185	19	model	model	NOUN
admet-628	185	20	to	to	PART
admet-628	185	21	available	available	VERB
admet-628	185	22	data	datum	NOUN
admet-628	185	23	.	.	PUNCT
admet-628	186	1	optimization	optimization	NOUN
admet-628	186	2	was	be	AUX
admet-628	186	3	accomplished	accomplish	VERB
admet-628	186	4	by	by	ADP
admet-628	186	5	minimizing	minimize	VERB
admet-628	186	6	the	the	DET
admet-628	186	7	squared	square	VERB
admet-628	186	8	differences	difference	NOUN
admet-628	186	9	between	between	ADP
admet-628	186	10	model	model	NOUN
admet-628	186	11	prediction	prediction	NOUN
admet-628	186	12	and	and	CCONJ
admet-628	186	13	the	the	DET
admet-628	186	14	experimental	experimental	ADJ
admet-628	186	15	data	datum	NOUN
admet-628	186	16	using	use	VERB
admet-628	186	17	the	the	DET
admet-628	186	18	maximized	maximize	VERB
admet-628	186	19	log	log	NOUN
admet-628	186	20	likelihood	likelihood	NOUN
admet-628	186	21	function	function	NOUN
admet-628	186	22	of	of	ADP
admet-628	186	23	the	the	DET
admet-628	186	24	acslxtreme	acslxtreme	PROPN
admet-628	186	25	®	®	PROPN
admet-628	186	26	optstat	optstat	PROPN
admet-628	186	27	program	program	NOUN
admet-628	186	28	(	(	PUNCT
admet-628	186	29	aegis	aegis	PROPN
admet-628	186	30	technologies	technology	NOUN
admet-628	186	31	group	group	PROPN
admet-628	186	32	,	,	PUNCT
admet-628	186	33	inc	inc	PROPN
admet-628	186	34	.	.	PROPN
admet-628	186	35	,	,	PUNCT
admet-628	186	36	huntsville	huntsville	PROPN
admet-628	186	37	,	,	PUNCT
admet-628	186	38	al	al	PROPN
admet-628	186	39	)	)	PUNCT
admet-628	186	40	.	.	PUNCT
admet-628	187	1	only	only	ADV
admet-628	187	2	the	the	DET
admet-628	187	3	parameters	parameter	NOUN
admet-628	187	4	that	that	PRON
admet-628	187	5	needed	need	VERB
admet-628	187	6	to	to	PART
admet-628	187	7	be	be	AUX
admet-628	187	8	parameterized	parameterized	ADJ
admet-628	187	9	were	be	AUX
admet-628	187	10	varied	varied	ADJ
admet-628	187	11	,	,	PUNCT
admet-628	187	12	the	the	DET
admet-628	187	13	values	value	NOUN
admet-628	187	14	of	of	ADP
admet-628	187	15	other	other	ADJ
admet-628	187	16	parameters	parameter	NOUN
admet-628	187	17	in	in	ADP
admet-628	187	18	tables	table	NOUN
admet-628	187	19	1	1	NUM
admet-628	187	20	and	and	CCONJ
admet-628	187	21	2	2	NUM
admet-628	187	22	were	be	AUX
admet-628	187	23	kept	keep	VERB
admet-628	187	24	constant	constant	ADJ
admet-628	187	25	.	.	PUNCT
admet-628	188	1	admet	admet	PROPN
admet-628	188	2	&	&	CCONJ
admet-628	188	3	dmpk	dmpk	PROPN
admet-628	188	4	7(1	7(1	PROPN
admet-628	188	5	)	)	PUNCT
admet-628	188	6	(	(	PUNCT
admet-628	188	7	2019	2019	NUM
admet-628	188	8	)	)	PUNCT
admet-628	188	9	22	22	NUM
admet-628	188	10	-	-	SYM
admet-628	188	11	43	43	NUM
admet-628	188	12	a	a	DET
admet-628	188	13	physiologically	physiologically	ADV
admet-628	188	14	-	-	PUNCT
admet-628	188	15	based	base	VERB
admet-628	188	16	pharmacokinetic	pharmacokinetic	ADJ
admet-628	188	17	model	model	NOUN
admet-628	188	18	for	for	ADP
admet-628	188	19	oseltamivir	oseltamivir	PROPN
admet-628	188	20	doi	doi	PROPN
admet-628	188	21	:	:	PUNCT
admet-628	188	22	10.5599	10.5599	NUM
admet-628	188	23	/	/	SYM
admet-628	188	24	admet.628	admet.628	PROPN
admet-628	188	25	29	29	NUM
admet-628	188	26	table	table	NOUN
admet-628	188	27	3	3	NUM
admet-628	188	28	.	.	PUNCT
admet-628	188	29	normalized	normalize	VERB
admet-628	188	30	sensitivity	sensitivity	NOUN
admet-628	188	31	coefficients	coefficient	NOUN
admet-628	188	32	for	for	ADP
admet-628	188	33	oc	oc	NOUN
admet-628	188	34	concentrations	concentration	NOUN
admet-628	188	35	in	in	ADP
admet-628	188	36	the	the	DET
admet-628	188	37	lung	lung	NOUN
admet-628	188	38	and	and	CCONJ
admet-628	188	39	the	the	DET
admet-628	188	40	plasma	plasma	NOUN
admet-628	188	41	based	base	VERB
admet-628	188	42	on	on	ADP
admet-628	188	43	the	the	DET
admet-628	188	44	simulated	simulate	VERB
admet-628	188	45	data	datum	NOUN
admet-628	188	46	of	of	ADP
admet-628	188	47	administering	administer	VERB
admet-628	188	48	10	10	NUM
admet-628	188	49	mg	mg	NUM
admet-628	188	50	/	/	SYM
admet-628	188	51	kg	kg	PROPN
admet-628	188	52	op	op	NOUN
admet-628	188	53	p.o	p.o	PROPN
admet-628	188	54	.	.	PROPN
admet-628	188	55	to	to	ADP
admet-628	188	56	the	the	DET
admet-628	188	57	rat	rat	NOUN
admet-628	188	58	*	*	ADJ
admet-628	188	59	pulmonary	pulmonary	NOUN
admet-628	188	60	oc	oc	ADP
admet-628	188	61	concentration	concentration	NOUN
admet-628	188	62	-	-	PUNCT
admet-628	188	63	time	time	NOUN
admet-628	188	64	data	datum	NOUN
admet-628	188	65	as	as	ADP
admet-628	188	66	the	the	DET
admet-628	188	67	model	model	NOUN
admet-628	188	68	output	output	NOUN
admet-628	188	69	surrogate	surrogate	ADJ
admet-628	188	70	time	time	NOUN
admet-628	188	71	(	(	PUNCT
admet-628	188	72	h	h	NOUN
admet-628	188	73	)	)	PUNCT
admet-628	188	74	parameter	parameter	NOUN
admet-628	188	75	0.5	0.5	NUM
admet-628	188	76	1	1	NUM
admet-628	188	77	2	2	NUM
admet-628	188	78	4	4	NUM
admet-628	188	79	6	6	NUM
admet-628	188	80	8	8	NUM
admet-628	188	81	10	10	NUM
admet-628	188	82	12	12	NUM
admet-628	188	83	high	high	ADJ
admet-628	188	84	(	(	PUNCT
admet-628	188	85	>	>	X
admet-628	188	86	0.5	0.5	NUM
admet-628	188	87	)	)	PUNCT
admet-628	188	88	f	f	PROPN
admet-628	188	89	0.03	0.03	NUM
admet-628	188	90	0.67	0.67	NUM
admet-628	188	91	0.44	0.44	NUM
admet-628	188	92	0.11	0.11	NUM
admet-628	188	93	0.02	0.02	NUM
admet-628	188	94	-	-	PUNCT
admet-628	188	95	*	*	PUNCT
admet-628	188	96	*	*	NOUN
admet-628	188	97	tlag	tlag	NOUN
admet-628	188	98	-0.59	-0.59	NUM
admet-628	188	99	-0.03	-0.03	NUM
admet-628	188	100	0.12	0.12	NUM
admet-628	188	101	0.04	0.04	NUM
admet-628	188	102	0.01	0.01	NUM
admet-628	188	103	medium	medium	NOUN
admet-628	188	104	vmax	vmax	PROPN
admet-628	188	105	0.03	0.03	NUM
admet-628	188	106	0.50	0.50	NUM
admet-628	188	107	0.25	0.25	NUM
admet-628	188	108	0.03	0.03	NUM
admet-628	188	109	km	km	NOUN
admet-628	188	110	-0.03	-0.03	NUM
admet-628	188	111	-0.49	-0.49	ADP
admet-628	188	112	-0.25	-0.25	NUM
admet-628	188	113	-0.03	-0.03	NUM
admet-628	188	114	low	low	NOUN
admet-628	188	115	(	(	PUNCT
admet-628	188	116	<	<	NOUN
admet-628	188	117	0.2	0.2	NUM
admet-628	188	118	)	)	PUNCT
admet-628	188	119	clc	clc	PROPN
admet-628	188	120	-0.09	-0.09	PROPN
admet-628	188	121	-0.18	-0.18	PROPN
admet-628	188	122	-0.09	-0.09	NUM
admet-628	188	123	-0.02	-0.02	NUM
admet-628	188	124	-0.01	-0.01	NUM
admet-628	188	125	clp	clp	PROPN
admet-628	188	126	-0.02	-0.02	NUM
admet-628	188	127	-0.06	-0.06	NUM
admet-628	188	128	-0.04	-0.04	NUM
admet-628	188	129	-0.02	-0.02	NUM
admet-628	188	130	ka	ka	PROPN
admet-628	188	131	0.03	0.03	NUM
admet-628	188	132	0.03	0.03	NUM
admet-628	188	133	-0.02	-0.02	NUM
admet-628	188	134	-0.01	-0.01	NUM
admet-628	188	135	blplrc	blplrc	ADJ
admet-628	188	136	0	0	PUNCT
admet-628	189	1	*	*	PUNCT
admet-628	189	2	*	*	PUNCT
admet-628	189	3	*	*	PUNCT
admet-628	189	4	0	0	NUM
admet-628	189	5	0	0	NUM
admet-628	189	6	0	0	NUM
admet-628	189	7	0	0	NUM
admet-628	189	8	0	0	NUM
admet-628	189	9	0	0	NUM
admet-628	189	10	0	0	NUM
admet-628	189	11	blplrp	blplrp	NOUN
admet-628	189	12	0	0	NUM
admet-628	189	13	0	0	NUM
admet-628	189	14	0	0	NUM
admet-628	189	15	0	0	NUM
admet-628	189	16	0	0	NUM
admet-628	189	17	0	0	NUM
admet-628	189	18	0	0	NUM
admet-628	189	19	0	0	NUM
admet-628	189	20	plasma	plasma	NOUN
admet-628	189	21	oc	oc	ADP
admet-628	189	22	concentration	concentration	NOUN
admet-628	189	23	-	-	PUNCT
admet-628	189	24	time	time	NOUN
admet-628	189	25	data	datum	NOUN
admet-628	189	26	as	as	SCONJ
admet-628	189	27	the	the	DET
admet-628	189	28	model	model	NOUN
admet-628	189	29	output	output	NOUN
admet-628	189	30	surrogate	surrogate	ADJ
admet-628	189	31	high	high	ADJ
admet-628	189	32	(	(	PUNCT
admet-628	189	33	>	>	X
admet-628	189	34	0.5	0.5	NUM
admet-628	189	35	)	)	PUNCT
admet-628	190	1	blplrc	blplrc	PROPN
admet-628	190	2	-0.03	-0.03	X
admet-628	190	3	-0.68	-0.68	PROPN
admet-628	190	4	-0.45	-0.45	NUM
admet-628	190	5	-0.11	-0.11	NUM
admet-628	190	6	-0.02	-0.02	NUM
admet-628	190	7	f	f	PROPN
admet-628	190	8	0.03	0.03	NUM
admet-628	190	9	0.67	0.67	NUM
admet-628	190	10	0.44	0.44	NUM
admet-628	190	11	0.11	0.11	NUM
admet-628	190	12	0.02	0.02	NUM
admet-628	190	13	tlag	tlag	NOUN
admet-628	190	14	-0.59	-0.59	NUM
admet-628	190	15	-0.03	-0.03	NUM
admet-628	190	16	0.12	0.12	NUM
admet-628	190	17	0.04	0.04	NUM
admet-628	190	18	0.01	0.01	NUM
admet-628	190	19	medium	medium	NOUN
admet-628	190	20	vmax	vmax	PROPN
admet-628	190	21	0.03	0.03	NUM
admet-628	190	22	0.50	0.50	NUM
admet-628	190	23	0.25	0.25	NUM
admet-628	190	24	0.03	0.03	NUM
admet-628	190	25	km	km	NOUN
admet-628	190	26	-0.03	-0.03	NUM
admet-628	190	27	-0.49	-0.49	ADP
admet-628	190	28	-0.25	-0.25	NUM
admet-628	190	29	-0.03	-0.03	NUM
admet-628	190	30	low	low	NOUN
admet-628	190	31	(	(	PUNCT
admet-628	190	32	<	<	NOUN
admet-628	190	33	0.2	0.2	NUM
admet-628	190	34	)	)	PUNCT
admet-628	190	35	clc	clc	PROPN
admet-628	190	36	-0.09	-0.09	PROPN
admet-628	190	37	-0.18	-0.18	PROPN
admet-628	190	38	-0.09	-0.09	NUM
admet-628	190	39	-0.02	-0.02	NUM
admet-628	190	40	-0.01	-0.01	NUM
admet-628	190	41	clp	clp	PROPN
admet-628	190	42	-0.02	-0.02	NUM
admet-628	190	43	-0.06	-0.06	PROPN
admet-628	190	44	-0.04	-0.04	NUM
admet-628	190	45	-0.01	-0.01	NUM
admet-628	190	46	ka	ka	PROPN
admet-628	190	47	0.03	0.03	NUM
admet-628	190	48	0.03	0.03	NUM
admet-628	190	49	-0.03	-0.03	NUM
admet-628	190	50	-0.01	-0.01	NUM
admet-628	190	51	blplrp	blplrp	NOUN
admet-628	190	52	0	0	NUM
admet-628	190	53	0	0	NUM
admet-628	190	54	0	0	NUM
admet-628	190	55	0	0	NUM
admet-628	190	56	0	0	NUM
admet-628	190	57	0	0	NUM
admet-628	190	58	0	0	NUM
admet-628	190	59	0	0	NUM
admet-628	191	1	*	*	PUNCT
admet-628	191	2	the	the	DET
admet-628	191	3	sensitivity	sensitivity	NOUN
admet-628	191	4	coefficients	coefficient	NOUN
admet-628	191	5	were	be	AUX
admet-628	191	6	determined	determine	VERB
admet-628	191	7	using	use	VERB
admet-628	191	8	the	the	DET
admet-628	191	9	parameter	parameter	NOUN
admet-628	191	10	values	value	NOUN
admet-628	191	11	from	from	ADP
admet-628	191	12	rats	rat	NOUN
admet-628	191	13	dosed	dose	VERB
admet-628	191	14	with	with	ADP
admet-628	191	15	a	a	DET
admet-628	191	16	single	single	ADJ
admet-628	191	17	oral	oral	ADJ
admet-628	191	18	dose	dose	NOUN
admet-628	191	19	of	of	ADP
admet-628	191	20	10	10	NUM
admet-628	191	21	mg	mg	NUM
admet-628	191	22	/	/	SYM
admet-628	191	23	kg	kg	NOUN
admet-628	191	24	op	op	NOUN
admet-628	191	25	(	(	PUNCT
admet-628	191	26	table	table	NOUN
admet-628	191	27	2	2	NUM
admet-628	191	28	)	)	PUNCT
admet-628	191	29	*	*	PUNCT
admet-628	191	30	*	*	PUNCT
admet-628	191	31	absolute	absolute	ADJ
admet-628	191	32	value	value	NOUN
admet-628	191	33	≤0.001	≤0.001	PUNCT
admet-628	191	34	*	*	PUNCT
admet-628	192	1	*	*	PUNCT
admet-628	192	2	*	*	PUNCT
admet-628	192	3	:	:	PUNCT
admet-628	192	4	0	0	NUM
admet-628	192	5	means	mean	VERB
admet-628	192	6	a	a	DET
admet-628	192	7	change	change	NOUN
admet-628	192	8	in	in	ADP
admet-628	192	9	parameter	parameter	NOUN
admet-628	192	10	value	value	NOUN
admet-628	192	11	did	do	AUX
admet-628	192	12	not	not	PART
admet-628	192	13	result	result	VERB
admet-628	192	14	in	in	ADP
admet-628	192	15	any	any	DET
admet-628	192	16	significant	significant	ADJ
admet-628	192	17	effect	effect	NOUN
admet-628	192	18	on	on	ADP
admet-628	192	19	model	model	NOUN
admet-628	192	20	outputs	outputs	PROPN
admet-628	192	21	validation	validation	NOUN
admet-628	192	22	and	and	CCONJ
admet-628	192	23	calibration	calibration	NOUN
admet-628	192	24	of	of	ADP
admet-628	192	25	pbpk	pbpk	NOUN
admet-628	192	26	model	model	NOUN
admet-628	192	27	.	.	PUNCT
admet-628	193	1	the	the	DET
admet-628	193	2	pbpk	pbpk	PROPN
admet-628	193	3	models	model	NOUN
admet-628	193	4	of	of	ADP
admet-628	193	5	rats	rat	NOUN
admet-628	193	6	and	and	CCONJ
admet-628	193	7	humans	human	NOUN
admet-628	193	8	were	be	AUX
admet-628	193	9	validated	validate	VERB
admet-628	193	10	or	or	CCONJ
admet-628	193	11	calibrated	calibrate	VERB
admet-628	193	12	by	by	ADP
admet-628	193	13	comparing	compare	VERB
admet-628	193	14	model	model	NOUN
admet-628	193	15	-	-	PUNCT
admet-628	193	16	simulated	simulate	VERB
admet-628	193	17	results	result	NOUN
admet-628	193	18	with	with	ADP
admet-628	193	19	experimental	experimental	ADJ
admet-628	193	20	data	datum	NOUN
admet-628	193	21	not	not	PART
admet-628	193	22	used	use	VERB
admet-628	193	23	in	in	ADP
admet-628	193	24	model	model	NOUN
admet-628	193	25	development	development	NOUN
admet-628	193	26	.	.	PUNCT
admet-628	194	1	the	the	DET
admet-628	194	2	empirical	empirical	ADJ
admet-628	194	3	data	datum	NOUN
admet-628	194	4	were	be	AUX
admet-628	194	5	obtained	obtain	VERB
admet-628	194	6	either	either	CCONJ
admet-628	194	7	from	from	ADP
admet-628	194	8	our	our	PRON
admet-628	194	9	own	own	ADJ
admet-628	194	10	laboratories	laboratory	NOUN
admet-628	194	11	or	or	CCONJ
admet-628	194	12	from	from	ADP
admet-628	194	13	the	the	DET
admet-628	194	14	literature	literature	NOUN
admet-628	194	15	.	.	PUNCT
admet-628	195	1	because	because	SCONJ
admet-628	195	2	we	we	PRON
admet-628	195	3	were	be	AUX
admet-628	195	4	unable	unable	ADJ
admet-628	195	5	to	to	PART
admet-628	195	6	obtain	obtain	VERB
admet-628	195	7	the	the	DET
admet-628	195	8	original	original	ADJ
admet-628	195	9	concentration	concentration	NOUN
admet-628	195	10	-	-	PUNCT
admet-628	195	11	time	time	NOUN
admet-628	195	12	data	datum	NOUN
admet-628	195	13	from	from	ADP
admet-628	195	14	the	the	DET
admet-628	195	15	literature	literature	NOUN
admet-628	195	16	,	,	PUNCT
admet-628	195	17	they	they	PRON
admet-628	195	18	were	be	AUX
admet-628	195	19	read	read	VERB
admet-628	195	20	digitally	digitally	ADV
admet-628	195	21	from	from	ADP
admet-628	195	22	the	the	DET
admet-628	195	23	publications	publication	NOUN
admet-628	195	24	using	use	VERB
admet-628	195	25	digimatic	digimatic	ADJ
admet-628	195	26	®	®	NOUN
admet-628	195	27	(	(	PUNCT
admet-628	195	28	windows	window	NOUN
admet-628	195	29	version	version	NOUN
admet-628	195	30	2.2c	2.2c	NUM
admet-628	195	31	,	,	PUNCT
admet-628	195	32	feb	feb	PROPN
admet-628	195	33	software	software	PROPN
admet-628	195	34	,	,	PUNCT
admet-628	195	35	chesterfield	chesterfield	PROPN
admet-628	195	36	,	,	PUNCT
admet-628	195	37	virginia	virginia	PROPN
admet-628	195	38	)	)	PUNCT
admet-628	195	39	.	.	PUNCT
admet-628	196	1	the	the	DET
admet-628	196	2	pbpk	pbpk	PROPN
admet-628	196	3	model	model	NOUN
admet-628	196	4	was	be	AUX
admet-628	196	5	assumed	assume	VERB
admet-628	196	6	to	to	PART
admet-628	196	7	be	be	AUX
admet-628	196	8	validated	validate	VERB
admet-628	196	9	if	if	SCONJ
admet-628	196	10	model	model	NOUN
admet-628	196	11	simulation	simulation	NOUN
admet-628	196	12	described	describe	VERB
admet-628	196	13	closely	closely	ADV
admet-628	196	14	the	the	DET
admet-628	196	15	experimental	experimental	ADJ
admet-628	196	16	data	datum	NOUN
admet-628	196	17	.	.	PUNCT
admet-628	197	1	thus	thus	ADV
admet-628	197	2	,	,	PUNCT
admet-628	197	3	the	the	DET
admet-628	197	4	rat	rat	NOUN
admet-628	197	5	pbpk	pbpk	NOUN
admet-628	197	6	model	model	NOUN
admet-628	197	7	was	be	AUX
admet-628	197	8	validated	validate	VERB
admet-628	197	9	using	use	VERB
admet-628	197	10	the	the	DET
admet-628	197	11	experimental	experimental	ADJ
admet-628	197	12	data	datum	NOUN
admet-628	197	13	from	from	ADP
admet-628	197	14	rats	rat	NOUN
admet-628	197	15	dosed	dose	VERB
admet-628	197	16	with	with	ADP
admet-628	197	17	a	a	DET
admet-628	197	18	single	single	ADJ
admet-628	197	19	oral	oral	ADJ
admet-628	197	20	dose	dose	NOUN
admet-628	197	21	of	of	ADP
admet-628	197	22	50	50	NUM
admet-628	197	23	mg	mg	NUM
admet-628	197	24	/	/	SYM
admet-628	197	25	kg	kg	NOUN
admet-628	197	26	op	op	NOUN
admet-628	197	27	.	.	PUNCT
admet-628	198	1	the	the	DET
admet-628	198	2	rat	rat	NOUN
admet-628	198	3	model	model	NOUN
admet-628	198	4	was	be	AUX
admet-628	198	5	further	far	ADV
admet-628	198	6	validated	validate	VERB
admet-628	198	7	using	use	VERB
admet-628	198	8	the	the	DET
admet-628	198	9	plasma	plasma	NOUN
admet-628	198	10	concentration	concentration	NOUN
admet-628	198	11	-	-	PUNCT
admet-628	198	12	time	time	NOUN
admet-628	198	13	data	datum	NOUN
admet-628	198	14	from	from	ADP
admet-628	198	15	rats	rat	NOUN
admet-628	198	16	after	after	ADP
admet-628	198	17	receiving	receive	VERB
admet-628	198	18	a	a	DET
admet-628	198	19	single	single	ADJ
admet-628	198	20	oral	oral	ADJ
admet-628	198	21	dose	dose	NOUN
admet-628	198	22	of	of	ADP
admet-628	198	23	30	30	NUM
admet-628	198	24	mg	mg	PROPN
admet-628	198	25	/	/	SYM
admet-628	198	26	kg	kg	NOUN
admet-628	198	27	op	op	NOUN
admet-628	198	28	or	or	CCONJ
admet-628	198	29	an	an	DET
admet-628	198	30	i.v	i.v	PROPN
admet-628	198	31	.	.	PUNCT
admet-628	199	1	infusion	infusion	NOUN
admet-628	199	2	of	of	ADP
admet-628	199	3	30	30	NUM
admet-628	199	4	mg	mg	PROPN
admet-628	199	5	/	/	SYM
admet-628	199	6	kg	kg	NOUN
admet-628	199	7	oc	oc	ADP
admet-628	200	1	[	[	X
admet-628	200	2	37	37	NUM
admet-628	200	3	]	]	PUNCT
admet-628	200	4	.	.	PUNCT
admet-628	201	1	similarly	similarly	ADV
admet-628	201	2	,	,	PUNCT
admet-628	201	3	the	the	DET
admet-628	201	4	human	human	ADJ
admet-628	201	5	pbpk	pbpk	PROPN
admet-628	201	6	model	model	NOUN
admet-628	201	7	was	be	AUX
admet-628	201	8	calibrated	calibrate	VERB
admet-628	201	9	using	use	VERB
admet-628	201	10	the	the	DET
admet-628	201	11	datasets	dataset	NOUN
admet-628	201	12	reported	report	VERB
admet-628	201	13	by	by	ADP
admet-628	201	14	he	he	PRON
admet-628	201	15	et	et	PROPN
admet-628	201	16	al	al	PROPN
admet-628	201	17	.	.	PUNCT
admet-628	202	1	[	[	X
admet-628	202	2	14	14	NUM
admet-628	202	3	]	]	PUNCT
admet-628	202	4	for	for	ADP
admet-628	202	5	human	human	ADJ
admet-628	202	6	volunteers	volunteer	NOUN
admet-628	202	7	dosed	dose	VERB
admet-628	202	8	with	with	ADP
admet-628	202	9	a	a	DET
admet-628	202	10	single	single	ADJ
admet-628	202	11	oral	oral	ADJ
admet-628	202	12	dose	dose	NOUN
admet-628	202	13	of	of	ADP
admet-628	202	14	150	150	NUM
admet-628	202	15	mg	mg	NOUN
admet-628	202	16	op	op	NOUN
admet-628	202	17	or	or	CCONJ
admet-628	202	18	an	an	DET
admet-628	202	19	i.v	i.v	PROPN
admet-628	202	20	.	.	PUNCT
admet-628	203	1	infusion	infusion	NOUN
admet-628	203	2	of	of	ADP
admet-628	203	3	150	150	NUM
admet-628	203	4	mg	mg	NOUN
admet-628	203	5	oc	oc	PROPN
admet-628	203	6	.	.	PUNCT
admet-628	204	1	the	the	DET
admet-628	204	2	human	human	ADJ
admet-628	204	3	model	model	NOUN
admet-628	204	4	was	be	AUX
admet-628	204	5	further	far	ADV
admet-628	204	6	validated	validate	VERB
admet-628	204	7	based	base	VERB
admet-628	204	8	on	on	ADP
admet-628	204	9	the	the	DET
admet-628	204	10	experimental	experimental	ADJ
admet-628	204	11	data	datum	NOUN
admet-628	204	12	of	of	ADP
admet-628	204	13	humans	human	NOUN
admet-628	204	14	receiving	receive	VERB
admet-628	204	15	multiple	multiple	ADJ
admet-628	204	16	oral	oral	ADJ
admet-628	204	17	doses	dose	NOUN
admet-628	204	18	of	of	ADP
admet-628	204	19	50	50	NUM
admet-628	204	20	,	,	PUNCT
admet-628	204	21	100	100	NUM
admet-628	204	22	,	,	PUNCT
admet-628	204	23	200	200	NUM
admet-628	204	24	or	or	CCONJ
admet-628	204	25	500	500	NUM
admet-628	204	26	mg	mg	NOUN
admet-628	204	27	of	of	ADP
admet-628	204	28	op	op	NOUN
admet-628	204	29	b.i.d	b.i.d	PROPN
admet-628	204	30	.	.	PUNCT
admet-628	205	1	for	for	ADP
admet-628	205	2	one	one	NUM
admet-628	205	3	week	week	NOUN
admet-628	205	4	.	.	PUNCT
admet-628	206	1	statistical	statistical	ADJ
admet-628	206	2	and	and	CCONJ
admet-628	206	3	sensitivity	sensitivity	NOUN
admet-628	206	4	analyses	analysis	NOUN
admet-628	206	5	.	.	PUNCT
admet-628	207	1	mean	mean	VERB
admet-628	207	2	absolute	absolute	ADJ
admet-628	207	3	prediction	prediction	NOUN
admet-628	207	4	error	error	NOUN
admet-628	207	5	(	(	PUNCT
admet-628	207	6	mape	mape	NOUN
admet-628	207	7	)	)	PUNCT
admet-628	207	8	was	be	AUX
admet-628	207	9	used	use	VERB
admet-628	207	10	as	as	ADP
admet-628	207	11	a	a	DET
admet-628	207	12	measure	measure	NOUN
admet-628	207	13	of	of	ADP
admet-628	207	14	good	good	ADJ
admet-628	207	15	fit	fit	NOUN
admet-628	207	16	between	between	ADP
admet-628	207	17	model	model	NOUN
admet-628	207	18	-	-	PUNCT
admet-628	207	19	predicted	predict	VERB
admet-628	207	20	concentration	concentration	NOUN
admet-628	207	21	(	(	PUNCT
admet-628	207	22	cpredi	cpredi	NOUN
admet-628	207	23	)	)	PUNCT
admet-628	207	24	and	and	CCONJ
admet-628	207	25	experimental	experimental	ADJ
admet-628	207	26	concentration	concentration	NOUN
admet-628	207	27	(	(	PUNCT
admet-628	207	28	cexpti	cexpti	PROPN
admet-628	207	29	)	)	PUNCT
admet-628	207	30	.	.	PUNCT
admet-628	208	1	it	it	PRON
admet-628	208	2	was	be	AUX
admet-628	208	3	g.	g.	PROPN
admet-628	208	4	gao	gao	PROPN
admet-628	208	5	et	et	PROPN
admet-628	208	6	al	al	PROPN
admet-628	208	7	.	.	PROPN
admet-628	208	8	admet	admet	PROPN
admet-628	208	9	&	&	CCONJ
admet-628	208	10	dmpk	dmpk	PROPN
admet-628	208	11	7(1	7(1	PROPN
admet-628	208	12	)	)	PUNCT
admet-628	208	13	(	(	PUNCT
admet-628	208	14	2019	2019	NUM
admet-628	208	15	)	)	PUNCT
admet-628	208	16	22	22	NUM
admet-628	208	17	-	-	SYM
admet-628	208	18	43	43	NUM
admet-628	208	19	30	30	NUM
admet-628	208	20	calculated	calculate	VERB
admet-628	208	21	using	use	VERB
admet-628	208	22	the	the	DET
admet-628	208	23	following	follow	VERB
admet-628	208	24	equation	equation	NOUN
admet-628	208	25	:	:	PUNCT
admet-628	208	26	exp	exp	NOUN
admet-628	208	27	exp	exp	NOUN
admet-628	208	28	1	1	NUM
admet-628	208	29	mape	mape	NOUN
admet-628	208	30	(	(	PUNCT
admet-628	208	31	%	%	NOUN
admet-628	208	32	)	)	PUNCT
admet-628	208	33	(	(	PUNCT
admet-628	208	34	100	100	NUM
admet-628	208	35	/	/	SYM
admet-628	208	36	)	)	PUNCT
admet-628	208	37	/	/	SYM
admet-628	208	38	n	n	CCONJ
admet-628	208	39	ti	ti	NOUN
admet-628	208	40	predi	predi	NOUN
admet-628	208	41	ti	ti	NOUN
admet-628	208	42	i	i	PRON
admet-628	208	43	n	n	VERB
admet-628	208	44	c	c	NOUN
admet-628	208	45	c	c	NOUN
admet-628	208	46	c	c	NOUN
admet-628	209	1			PROPN
admet-628	209	2			NOUN
admet-628	209	3			NOUN
admet-628	209	4			PROPN
admet-628	209	5			PROPN
admet-628	209	6			PROPN
admet-628	210	1			ADJ
admet-628	210	2			NOUN
admet-628	210	3	(	(	PUNCT
admet-628	210	4	1	1	NUM
admet-628	210	5	)	)	PUNCT
admet-628	210	6	where	where	SCONJ
admet-628	210	7	,	,	PUNCT
admet-628	210	8	i	i	PRON
admet-628	210	9	represents	represent	VERB
admet-628	210	10	individual	individual	ADJ
admet-628	210	11	data	datum	NOUN
admet-628	210	12	points	point	NOUN
admet-628	210	13	;	;	PUNCT
admet-628	210	14	n	n	X
admet-628	210	15	is	be	AUX
admet-628	210	16	the	the	DET
admet-628	210	17	total	total	ADJ
admet-628	210	18	number	number	NOUN
admet-628	210	19	of	of	ADP
admet-628	210	20	data	datum	NOUN
admet-628	210	21	points	point	NOUN
admet-628	210	22	.	.	PUNCT
admet-628	211	1	a	a	DET
admet-628	211	2	deviation	deviation	NOUN
admet-628	211	3	within	within	ADP
admet-628	211	4	a	a	DET
admet-628	211	5	factor	factor	NOUN
admet-628	211	6	of	of	ADP
admet-628	211	7	two	two	NUM
admet-628	211	8	between	between	ADP
admet-628	211	9	predicted	predict	VERB
admet-628	211	10	and	and	CCONJ
admet-628	211	11	experimental	experimental	ADJ
admet-628	211	12	concentration	concentration	NOUN
admet-628	211	13	data	datum	NOUN
admet-628	211	14	(	(	PUNCT
admet-628	211	15	i.e.	i.e.	X
admet-628	211	16	,	,	PUNCT
admet-628	211	17	mape<50	mape<50	ADJ
admet-628	211	18	%	%	NOUN
admet-628	211	19	)	)	PUNCT
admet-628	211	20	was	be	AUX
admet-628	211	21	used	use	VERB
admet-628	211	22	as	as	ADP
admet-628	211	23	the	the	DET
admet-628	211	24	criteria	criterion	NOUN
admet-628	211	25	for	for	ADP
admet-628	211	26	goodness	goodness	NOUN
admet-628	211	27	of	of	ADP
admet-628	211	28	fit	fit	NOUN
admet-628	211	29	[	[	X
admet-628	211	30	38	38	NUM
admet-628	211	31	]	]	PUNCT
admet-628	211	32	.	.	PUNCT
admet-628	212	1	log	log	NOUN
admet-628	212	2	-	-	PUNCT
admet-628	212	3	normalized	normalize	VERB
admet-628	212	4	sensitivity	sensitivity	NOUN
admet-628	212	5	parameter	parameter	NOUN
admet-628	212	6	(	(	PUNCT
admet-628	212	7	lsp	lsp	PROPN
admet-628	212	8	)	)	PUNCT
admet-628	212	9	was	be	AUX
admet-628	212	10	used	use	VERB
admet-628	212	11	to	to	PART
admet-628	212	12	identify	identify	VERB
admet-628	212	13	key	key	ADJ
admet-628	212	14	model	model	NOUN
admet-628	212	15	parameters	parameter	NOUN
admet-628	212	16	that	that	PRON
admet-628	212	17	had	have	VERB
admet-628	212	18	significant	significant	ADJ
admet-628	212	19	impacts	impact	NOUN
admet-628	212	20	on	on	ADP
admet-628	212	21	model	model	NOUN
admet-628	212	22	prediction	prediction	NOUN
admet-628	212	23	.	.	PUNCT
admet-628	213	1	lsp	lsp	PROPN
admet-628	213	2	was	be	AUX
admet-628	213	3	defined	define	VERB
admet-628	213	4	as	as	ADP
admet-628	213	5	the	the	DET
admet-628	213	6	partial	partial	ADJ
admet-628	213	7	derivatives	derivative	NOUN
admet-628	213	8	of	of	ADP
admet-628	213	9	model	model	NOUN
admet-628	213	10	response	response	NOUN
admet-628	213	11	to	to	ADP
admet-628	213	12	the	the	DET
admet-628	213	13	corresponding	corresponding	ADJ
admet-628	213	14	model	model	NOUN
admet-628	213	15	parameter	parameter	NOUN
admet-628	214	1	[	[	X
admet-628	214	2	39	39	NUM
admet-628	214	3	]	]	PUNCT
admet-628	214	4	:	:	PUNCT
admet-628	215	1	lsp	lsp	PROPN
admet-628	215	2	=	=	PUNCT
admet-628	216	1	∂ln	∂ln	PROPN
admet-628	216	2	r/∂ln	r/∂ln	ADJ
admet-628	216	3	x	x	X
admet-628	216	4	(	(	PUNCT
admet-628	216	5	2	2	NUM
admet-628	216	6	)	)	PUNCT
admet-628	216	7	where	where	SCONJ
admet-628	216	8	r	r	NOUN
admet-628	216	9	is	be	AUX
admet-628	216	10	the	the	DET
admet-628	216	11	model	model	NOUN
admet-628	216	12	output	output	NOUN
admet-628	216	13	and	and	CCONJ
admet-628	216	14	x	x	X
admet-628	216	15	is	be	AUX
admet-628	216	16	the	the	DET
admet-628	216	17	parameter	parameter	NOUN
admet-628	216	18	for	for	ADP
admet-628	216	19	which	which	PRON
admet-628	216	20	the	the	DET
admet-628	216	21	sensitivity	sensitivity	NOUN
admet-628	216	22	is	be	AUX
admet-628	216	23	assessed	assess	VERB
admet-628	216	24	.	.	PUNCT
admet-628	217	1	the	the	DET
admet-628	217	2	sensitivity	sensitivity	NOUN
admet-628	217	3	analysis	analysis	NOUN
admet-628	217	4	was	be	AUX
admet-628	217	5	conducted	conduct	VERB
admet-628	217	6	by	by	ADP
admet-628	217	7	acslxtreme	acslxtreme	NOUN
admet-628	217	8	2.0.1.2	2.0.1.2	NUM
admet-628	217	9	(	(	PUNCT
admet-628	217	10	aegis	aegis	PROPN
admet-628	217	11	technologies	technology	NOUN
admet-628	217	12	group	group	PROPN
admet-628	217	13	,	,	PUNCT
admet-628	217	14	inc	inc	PROPN
admet-628	217	15	.	.	PROPN
admet-628	217	16	,	,	PUNCT
admet-628	217	17	huntsville	huntsville	PROPN
admet-628	217	18	,	,	PUNCT
admet-628	217	19	al	al	PROPN
admet-628	217	20	)	)	PUNCT
admet-628	217	21	using	use	VERB
admet-628	217	22	the	the	DET
admet-628	217	23	central	central	ADJ
admet-628	217	24	difference	difference	NOUN
admet-628	217	25	method	method	NOUN
admet-628	217	26	.	.	PUNCT
admet-628	218	1	the	the	DET
admet-628	218	2	lsp	lsp	PROPN
admet-628	218	3	represented	represent	VERB
admet-628	218	4	the	the	DET
admet-628	218	5	percentage	percentage	NOUN
admet-628	218	6	change	change	NOUN
admet-628	218	7	in	in	ADP
admet-628	218	8	an	an	DET
admet-628	218	9	output	output	NOUN
admet-628	218	10	value	value	NOUN
admet-628	218	11	associated	associate	VERB
admet-628	218	12	with	with	ADP
admet-628	218	13	the	the	DET
admet-628	218	14	percentage	percentage	NOUN
admet-628	218	15	change	change	NOUN
admet-628	218	16	in	in	ADP
admet-628	218	17	the	the	DET
admet-628	218	18	input	input	NOUN
admet-628	218	19	parameter	parameter	NOUN
admet-628	218	20	.	.	PUNCT
admet-628	219	1	the	the	DET
admet-628	219	2	plasma	plasma	NOUN
admet-628	219	3	and	and	CCONJ
admet-628	219	4	lung	lung	NOUN
admet-628	219	5	oc	oc	NOUN
admet-628	219	6	concentrations	concentration	NOUN
admet-628	219	7	were	be	AUX
admet-628	219	8	chosen	choose	VERB
admet-628	219	9	as	as	ADP
admet-628	219	10	the	the	DET
admet-628	219	11	target	target	NOUN
admet-628	219	12	tissues	tissue	NOUN
admet-628	219	13	for	for	ADP
admet-628	219	14	model	model	NOUN
admet-628	219	15	responses	response	NOUN
admet-628	219	16	following	follow	VERB
admet-628	219	17	oral	oral	ADJ
admet-628	219	18	administration	administration	NOUN
admet-628	219	19	of	of	ADP
admet-628	219	20	10	10	NUM
admet-628	219	21	mg	mg	PROPN
admet-628	219	22	/	/	SYM
admet-628	219	23	kg	kg	NOUN
admet-628	219	24	of	of	ADP
admet-628	219	25	op	op	NOUN
admet-628	219	26	to	to	ADP
admet-628	219	27	rats	rat	NOUN
admet-628	219	28	.	.	PUNCT
admet-628	220	1	model	model	NOUN
admet-628	220	2	parameters	parameter	NOUN
admet-628	220	3	were	be	AUX
admet-628	220	4	changed	change	VERB
admet-628	220	5	individually	individually	ADV
admet-628	220	6	by	by	ADP
admet-628	220	7	0.1	0.1	NUM
admet-628	220	8	%	%	NOUN
admet-628	220	9	to	to	PART
admet-628	220	10	assess	assess	VERB
admet-628	220	11	their	their	PRON
admet-628	220	12	impact	impact	NOUN
admet-628	220	13	on	on	ADP
admet-628	220	14	model	model	NOUN
admet-628	220	15	prediction	prediction	NOUN
admet-628	220	16	of	of	ADP
admet-628	220	17	plasma	plasma	NOUN
admet-628	220	18	and	and	CCONJ
admet-628	220	19	lung	lung	NOUN
admet-628	220	20	concentrations	concentration	NOUN
admet-628	220	21	.	.	PUNCT
admet-628	221	1	for	for	ADP
admet-628	221	2	each	each	DET
admet-628	221	3	model	model	NOUN
admet-628	221	4	response	response	NOUN
admet-628	221	5	,	,	PUNCT
admet-628	221	6	magnitude	magnitude	NOUN
admet-628	221	7	,	,	PUNCT
admet-628	221	8	time	time	NOUN
admet-628	221	9	dependency	dependency	NOUN
admet-628	221	10	,	,	PUNCT
admet-628	221	11	and	and	CCONJ
admet-628	221	12	the	the	DET
admet-628	221	13	mathematical	mathematical	ADJ
admet-628	221	14	sign	sign	NOUN
admet-628	221	15	of	of	ADP
admet-628	221	16	each	each	DET
admet-628	221	17	sensitivity	sensitivity	NOUN
admet-628	221	18	coefficient	coefficient	NOUN
admet-628	221	19	were	be	AUX
admet-628	221	20	examined	examine	VERB
admet-628	221	21	.	.	PUNCT
admet-628	222	1	the	the	DET
admet-628	222	2	ranking	ranking	NOUN
admet-628	222	3	of	of	ADP
admet-628	222	4	effects	effect	NOUN
admet-628	222	5	of	of	ADP
admet-628	222	6	input	input	NOUN
admet-628	222	7	parameters	parameter	NOUN
admet-628	222	8	on	on	ADP
admet-628	222	9	the	the	DET
admet-628	222	10	model	model	NOUN
admet-628	222	11	prediction	prediction	NOUN
admet-628	222	12	was	be	AUX
admet-628	222	13	based	base	VERB
admet-628	222	14	on	on	ADP
admet-628	222	15	the	the	DET
admet-628	222	16	absolute	absolute	ADJ
admet-628	222	17	magnitude	magnitude	NOUN
admet-628	222	18	of	of	ADP
admet-628	222	19	the	the	DET
admet-628	222	20	sensitivity	sensitivity	NOUN
admet-628	222	21	coefficient	coefficient	NOUN
admet-628	222	22	at	at	ADP
admet-628	222	23	the	the	DET
admet-628	222	24	time	time	NOUN
admet-628	222	25	[	[	X
admet-628	222	26	40	40	NUM
admet-628	222	27	]	]	PUNCT
admet-628	222	28	.	.	PUNCT
admet-628	223	1	generally	generally	ADV
admet-628	223	2	,	,	PUNCT
admet-628	223	3	the	the	DET
admet-628	223	4	parameters	parameter	NOUN
admet-628	223	5	that	that	PRON
admet-628	223	6	have	have	VERB
admet-628	223	7	large	large	ADJ
admet-628	223	8	absolute	absolute	ADJ
admet-628	223	9	sensitivity	sensitivity	NOUN
admet-628	223	10	coefficients	coefficient	NOUN
admet-628	223	11	often	often	ADV
admet-628	223	12	cause	cause	VERB
admet-628	223	13	sensitive	sensitive	ADJ
admet-628	223	14	model	model	NOUN
admet-628	223	15	outputs	output	NOUN
admet-628	223	16	in	in	ADP
admet-628	223	17	response	response	NOUN
admet-628	223	18	to	to	ADP
admet-628	223	19	a	a	DET
admet-628	223	20	small	small	ADJ
admet-628	223	21	change	change	NOUN
admet-628	223	22	in	in	ADP
admet-628	223	23	their	their	PRON
admet-628	223	24	values	value	NOUN
admet-628	223	25	because	because	SCONJ
admet-628	223	26	they	they	PRON
admet-628	223	27	have	have	VERB
admet-628	223	28	a	a	DET
admet-628	223	29	high	high	ADJ
admet-628	223	30	probability	probability	NOUN
admet-628	223	31	for	for	ADP
admet-628	223	32	prediction	prediction	NOUN
admet-628	223	33	error	error	NOUN
admet-628	223	34	to	to	PART
admet-628	223	35	occur	occur	VERB
admet-628	223	36	due	due	ADP
admet-628	223	37	to	to	ADP
admet-628	223	38	inaccuracy	inaccuracy	NOUN
admet-628	223	39	of	of	ADP
admet-628	223	40	the	the	DET
admet-628	223	41	parameter	parameter	NOUN
admet-628	223	42	values	value	NOUN
admet-628	223	43	.	.	PUNCT
admet-628	224	1	results	result	VERB
admet-628	224	2	development	development	NOUN
admet-628	224	3	and	and	CCONJ
admet-628	224	4	validation	validation	NOUN
admet-628	224	5	of	of	ADP
admet-628	224	6	rat	rat	NOUN
admet-628	224	7	pbpk	pbpk	NOUN
admet-628	224	8	model	model	NOUN
admet-628	224	9	table	table	NOUN
admet-628	224	10	2	2	NUM
admet-628	224	11	summarizes	summarize	NOUN
admet-628	224	12	the	the	DET
admet-628	224	13	final	final	ADJ
admet-628	224	14	parameter	parameter	NOUN
admet-628	224	15	values	value	NOUN
admet-628	224	16	used	use	VERB
admet-628	224	17	to	to	PART
admet-628	224	18	implement	implement	VERB
admet-628	224	19	the	the	DET
admet-628	224	20	rat	rat	NOUN
admet-628	224	21	and	and	CCONJ
admet-628	224	22	human	human	ADJ
admet-628	224	23	pbpk	pbpk	ADJ
admet-628	224	24	models	model	NOUN
admet-628	224	25	.	.	PUNCT
admet-628	225	1	the	the	DET
admet-628	225	2	oral	oral	ADJ
admet-628	225	3	bioavailability	bioavailability	NOUN
admet-628	225	4	factor	factor	NOUN
admet-628	225	5	(	(	PUNCT
admet-628	225	6	f	f	X
admet-628	225	7	)	)	PUNCT
admet-628	225	8	of	of	ADP
admet-628	225	9	op	op	NOUN
admet-628	225	10	was	be	AUX
admet-628	225	11	about	about	ADV
admet-628	225	12	80	80	NUM
admet-628	225	13	%	%	NOUN
admet-628	225	14	for	for	ADP
admet-628	225	15	both	both	DET
admet-628	225	16	rats	rat	NOUN
admet-628	225	17	and	and	CCONJ
admet-628	225	18	humans	human	NOUN
admet-628	225	19	.	.	PUNCT
admet-628	226	1	plasma	plasma	NOUN
admet-628	226	2	op	op	NOUN
admet-628	226	3	clearances	clearance	NOUN
admet-628	226	4	(	(	PUNCT
admet-628	226	5	clp	clp	NOUN
admet-628	226	6	)	)	PUNCT
admet-628	226	7	for	for	ADP
admet-628	226	8	humans	human	NOUN
admet-628	226	9	and	and	CCONJ
admet-628	226	10	rats	rat	NOUN
admet-628	226	11	were	be	AUX
admet-628	226	12	100	100	NUM
admet-628	226	13	l	l	NOUN
admet-628	226	14	/	/	SYM
admet-628	226	15	h	h	NOUN
admet-628	226	16	and	and	CCONJ
admet-628	226	17	0.4	0.4	NUM
admet-628	226	18	l	l	NOUN
admet-628	226	19	/	/	SYM
admet-628	226	20	h	h	NOUN
admet-628	226	21	,	,	PUNCT
admet-628	226	22	respectively	respectively	ADV
admet-628	226	23	.	.	PUNCT
admet-628	227	1	if	if	SCONJ
admet-628	227	2	the	the	DET
admet-628	227	3	clp	clp	PROPN
admet-628	227	4	values	value	NOUN
admet-628	227	5	were	be	AUX
admet-628	227	6	normalized	normalize	VERB
admet-628	227	7	by	by	ADP
admet-628	227	8	their	their	PRON
admet-628	227	9	respective	respective	ADJ
admet-628	227	10	body	body	NOUN
admet-628	227	11	weights	weight	NOUN
admet-628	227	12	,	,	PUNCT
admet-628	227	13	the	the	DET
admet-628	227	14	clp	clp	NOUN
admet-628	227	15	of	of	ADP
admet-628	227	16	humans	human	NOUN
admet-628	227	17	(	(	PUNCT
admet-628	227	18	1.4	1.4	NUM
admet-628	227	19	l	l	NOUN
admet-628	227	20	/	/	SYM
admet-628	227	21	kg	kg	ADJ
admet-628	227	22	/	/	SYM
admet-628	227	23	h	h	NOUN
admet-628	227	24	)	)	PUNCT
admet-628	227	25	and	and	CCONJ
admet-628	227	26	rats	rat	NOUN
admet-628	227	27	(	(	PUNCT
admet-628	227	28	1.6	1.6	NUM
admet-628	227	29	l	l	NOUN
admet-628	227	30	/	/	SYM
admet-628	227	31	kg	kg	PROPN
admet-628	227	32	/	/	SYM
admet-628	227	33	h	h	NOUN
admet-628	227	34	)	)	PUNCT
admet-628	227	35	were	be	AUX
admet-628	227	36	nearly	nearly	ADV
admet-628	227	37	identical	identical	ADJ
admet-628	227	38	.	.	PUNCT
admet-628	228	1	in	in	ADP
admet-628	228	2	contrast	contrast	NOUN
admet-628	228	3	,	,	PUNCT
admet-628	228	4	plasma	plasma	NOUN
admet-628	228	5	oc	oc	NOUN
admet-628	228	6	clearances	clearance	NOUN
admet-628	228	7	(	(	PUNCT
admet-628	228	8	clc	clc	PROPN
admet-628	228	9	)	)	PUNCT
admet-628	228	10	of	of	ADP
admet-628	228	11	rats	rat	NOUN
admet-628	228	12	and	and	CCONJ
admet-628	228	13	humans	human	NOUN
admet-628	228	14	were	be	AUX
admet-628	228	15	very	very	ADV
admet-628	228	16	different	different	ADJ
admet-628	228	17	even	even	ADV
admet-628	228	18	after	after	SCONJ
admet-628	228	19	they	they	PRON
admet-628	228	20	were	be	AUX
admet-628	228	21	normalized	normalize	VERB
admet-628	228	22	by	by	ADP
admet-628	228	23	the	the	DET
admet-628	228	24	body	body	NOUN
admet-628	228	25	weight	weight	NOUN
admet-628	228	26	;	;	PUNCT
admet-628	228	27	the	the	DET
admet-628	228	28	clc	clc	PROPN
admet-628	228	29	were	be	AUX
admet-628	228	30	18	18	NUM
admet-628	228	31	l	l	NOUN
admet-628	228	32	/	/	SYM
admet-628	228	33	h	h	NOUN
admet-628	228	34	for	for	ADP
admet-628	228	35	70	70	NUM
admet-628	228	36	kg	kg	NOUN
admet-628	228	37	bw	bw	ADP
admet-628	228	38	human	human	ADJ
admet-628	228	39	adult	adult	NOUN
admet-628	228	40	(	(	PUNCT
admet-628	228	41	0.26	0.26	NUM
admet-628	228	42	l	l	NOUN
admet-628	228	43	/	/	SYM
admet-628	228	44	kg	kg	ADJ
admet-628	228	45	/	/	SYM
admet-628	228	46	h	h	NOUN
admet-628	228	47	)	)	PUNCT
admet-628	228	48	and	and	CCONJ
admet-628	228	49	0.38	0.38	NUM
admet-628	228	50	l	l	NOUN
admet-628	228	51	/	/	SYM
admet-628	228	52	h	h	NOUN
admet-628	228	53	for	for	ADP
admet-628	228	54	0.25	0.25	NUM
admet-628	228	55	kg	kg	NOUN
admet-628	228	56	bw	bw	PROPN
admet-628	228	57	rat	rat	NOUN
admet-628	228	58	(	(	PUNCT
admet-628	228	59	1.5	1.5	NUM
admet-628	228	60	l	l	NOUN
admet-628	228	61	/	/	SYM
admet-628	228	62	kg	kg	PROPN
admet-628	228	63	/	/	SYM
admet-628	228	64	h	h	NOUN
admet-628	228	65	)	)	PUNCT
admet-628	228	66	,	,	PUNCT
admet-628	228	67	respectively	respectively	ADV
admet-628	228	68	(	(	PUNCT
admet-628	228	69	table	table	NOUN
admet-628	228	70	2	2	NUM
admet-628	228	71	)	)	PUNCT
admet-628	228	72	.	.	PUNCT
admet-628	229	1	the	the	DET
admet-628	229	2	km	km	PROPN
admet-628	229	3	and	and	CCONJ
admet-628	229	4	vmax	vmax	PROPN
admet-628	229	5	values	value	NOUN
admet-628	229	6	of	of	ADP
admet-628	229	7	op	op	NOUN
admet-628	229	8	biotransformation	biotransformation	NOUN
admet-628	229	9	were	be	AUX
admet-628	229	10	61.2	61.2	NUM
admet-628	229	11	mg	mg	NUM
admet-628	229	12	/	/	SYM
admet-628	229	13	h	h	NOUN
admet-628	229	14	(	(	PUNCT
admet-628	229	15	245	245	NUM
admet-628	229	16	mg	mg	PROPN
admet-628	229	17	/	/	SYM
admet-628	229	18	kg	kg	PROPN
admet-628	229	19	/	/	SYM
admet-628	229	20	h	h	NOUN
admet-628	229	21	)	)	PUNCT
admet-628	229	22	and	and	CCONJ
admet-628	229	23	300	300	NUM
admet-628	229	24	mg	mg	NUM
admet-628	229	25	/	/	SYM
admet-628	229	26	l	l	NOUN
admet-628	229	27	for	for	ADP
admet-628	229	28	rats	rat	NOUN
admet-628	229	29	,	,	PUNCT
admet-628	229	30	and	and	CCONJ
admet-628	229	31	2.6x105	2.6x105	ADJ
admet-628	229	32	mg	mg	PROPN
admet-628	229	33	/	/	SYM
admet-628	229	34	h	h	NOUN
admet-628	229	35	(	(	PUNCT
admet-628	229	36	3714	3714	NUM
admet-628	229	37	mg	mg	PROPN
admet-628	229	38	/	/	SYM
admet-628	229	39	kg	kg	PROPN
admet-628	229	40	/	/	SYM
admet-628	229	41	h	h	PROPN
admet-628	229	42	for	for	ADP
admet-628	229	43	70	70	NUM
admet-628	229	44	kg	kg	NOUN
admet-628	229	45	bw	bw	NOUN
admet-628	229	46	)	)	PUNCT
admet-628	229	47	and	and	CCONJ
admet-628	229	48	76	76	NUM
admet-628	229	49	mg	mg	PROPN
admet-628	229	50	/	/	SYM
admet-628	229	51	l	l	NOUN
admet-628	229	52	for	for	ADP
admet-628	229	53	humans	human	NOUN
admet-628	229	54	.	.	PUNCT
admet-628	230	1	op	op	NOUN
admet-628	230	2	/	/	SYM
admet-628	230	3	oc	oc	NOUN
admet-628	230	4	concentration	concentration	NOUN
admet-628	230	5	-	-	PUNCT
admet-628	230	6	time	time	NOUN
admet-628	230	7	profiles	profile	NOUN
admet-628	230	8	in	in	ADP
admet-628	230	9	plasma	plasma	NOUN
admet-628	230	10	/	/	SYM
admet-628	230	11	tissues	tissue	NOUN
admet-628	230	12	of	of	ADP
admet-628	230	13	rats	rat	NOUN
admet-628	230	14	op	op	NOUN
admet-628	230	15	was	be	AUX
admet-628	230	16	metabolized	metabolize	VERB
admet-628	230	17	primarily	primarily	ADV
admet-628	230	18	to	to	ADP
admet-628	230	19	oc	oc	VERB
admet-628	230	20	in	in	ADP
admet-628	230	21	rats	rat	NOUN
admet-628	230	22	.	.	PUNCT
admet-628	231	1	thus	thus	ADV
admet-628	231	2	,	,	PUNCT
admet-628	231	3	mostly	mostly	ADV
admet-628	231	4	oc	oc	X
admet-628	231	5	and	and	CCONJ
admet-628	231	6	occasionally	occasionally	ADV
admet-628	231	7	low	low	ADJ
admet-628	231	8	concentrations	concentration	NOUN
admet-628	231	9	of	of	ADP
admet-628	231	10	op	op	NOUN
admet-628	231	11	were	be	AUX
admet-628	231	12	found	find	VERB
admet-628	231	13	in	in	ADP
admet-628	231	14	the	the	DET
admet-628	231	15	plasma	plasma	NOUN
admet-628	231	16	(	(	PUNCT
admet-628	231	17	figs	fig	NOUN
admet-628	231	18	.	.	X
admet-628	231	19	3	3	NUM
admet-628	231	20	and	and	CCONJ
admet-628	231	21	4	4	NUM
admet-628	231	22	)	)	PUNCT
admet-628	231	23	although	although	SCONJ
admet-628	231	24	both	both	DET
admet-628	231	25	op	op	NOUN
admet-628	231	26	and	and	CCONJ
admet-628	231	27	oc	oc	PROPN
admet-628	231	28	were	be	AUX
admet-628	231	29	found	find	VERB
admet-628	231	30	in	in	ADP
admet-628	231	31	the	the	DET
admet-628	231	32	major	major	ADJ
admet-628	231	33	organs	organ	NOUN
admet-628	231	34	of	of	ADP
admet-628	231	35	rats	rat	NOUN
admet-628	231	36	.	.	PUNCT
admet-628	232	1	the	the	DET
admet-628	232	2	cmax	cmax	NOUN
admet-628	232	3	of	of	ADP
admet-628	232	4	oc	oc	NOUN
admet-628	232	5	in	in	ADP
admet-628	232	6	the	the	DET
admet-628	232	7	plasma	plasma	NOUN
admet-628	232	8	were	be	AUX
admet-628	232	9	0.80	0.80	NUM
admet-628	232	10	and	and	CCONJ
admet-628	232	11	5.63	5.63	NUM
admet-628	232	12	µg	µg	NOUN
admet-628	232	13	/	/	SYM
admet-628	232	14	ml	ml	NOUN
admet-628	232	15	,	,	PUNCT
admet-628	232	16	respectively	respectively	ADV
admet-628	232	17	after	after	ADP
admet-628	232	18	receiving	receive	VERB
admet-628	232	19	10	10	NUM
admet-628	232	20	mg	mg	NUM
admet-628	232	21	/	/	SYM
admet-628	232	22	kg	kg	PROPN
admet-628	232	23	and	and	CCONJ
admet-628	232	24	50	50	NUM
admet-628	232	25	mg	mg	NUM
admet-628	232	26	/	/	SYM
admet-628	232	27	kg	kg	NOUN
admet-628	232	28	of	of	ADP
admet-628	232	29	op	op	NOUN
admet-628	232	30	by	by	ADP
admet-628	232	31	the	the	DET
admet-628	232	32	rat	rat	NOUN
admet-628	232	33	.	.	PUNCT
admet-628	233	1	it	it	PRON
admet-628	233	2	decreased	decrease	VERB
admet-628	233	3	in	in	ADP
admet-628	233	4	the	the	DET
admet-628	233	5	order	order	NOUN
admet-628	233	6	of	of	ADP
admet-628	233	7	liver	liver	NOUN
admet-628	233	8	>	>	X
admet-628	233	9	kidney	kidney	PROPN
admet-628	233	10	>	>	X
admet-628	233	11	lung	lung	PROPN
admet-628	233	12	>	>	X
admet-628	233	13	plasma	plasma	NOUN
admet-628	233	14	(	(	PUNCT
admet-628	233	15	figs	fig	NOUN
admet-628	233	16	.	.	X
admet-628	233	17	3	3	NUM
admet-628	233	18	and	and	CCONJ
admet-628	233	19	4	4	NUM
admet-628	233	20	)	)	PUNCT
admet-628	233	21	.	.	PUNCT
admet-628	234	1	although	although	SCONJ
admet-628	234	2	op	op	NOUN
admet-628	234	3	was	be	AUX
admet-628	234	4	found	find	VERB
admet-628	234	5	at	at	ADP
admet-628	234	6	a	a	DET
admet-628	234	7	higher	high	ADJ
admet-628	234	8	concentration	concentration	NOUN
admet-628	234	9	than	than	ADP
admet-628	234	10	oc	oc	NOUN
admet-628	234	11	in	in	ADP
admet-628	234	12	the	the	DET
admet-628	234	13	lung	lung	NOUN
admet-628	234	14	(	(	PUNCT
admet-628	234	15	figs	fig	NOUN
admet-628	234	16	.	.	X
admet-628	235	1	3	3	NUM
admet-628	235	2	and	and	CCONJ
admet-628	235	3	4	4	NUM
admet-628	235	4	)	)	PUNCT
admet-628	236	1	and	and	CCONJ
admet-628	236	2	spleen	spleen	PROPN
admet-628	236	3	(	(	PUNCT
admet-628	236	4	data	datum	NOUN
admet-628	236	5	not	not	PART
admet-628	236	6	shown	show	VERB
admet-628	236	7	)	)	PUNCT
admet-628	236	8	,	,	PUNCT
admet-628	236	9	op	op	NOUN
admet-628	236	10	concentration	concentration	NOUN
admet-628	236	11	was	be	AUX
admet-628	236	12	lower	low	ADJ
admet-628	236	13	than	than	SCONJ
admet-628	236	14	oc	oc	ADP
admet-628	236	15	concentration	concentration	NOUN
admet-628	236	16	in	in	ADP
admet-628	236	17	kidney	kidney	NOUN
admet-628	236	18	,	,	PUNCT
admet-628	236	19	liver	liver	NOUN
admet-628	236	20	(	(	PUNCT
admet-628	236	21	figs	fig	NOUN
admet-628	236	22	.	.	X
admet-628	236	23	3	3	NUM
admet-628	236	24	and	and	CCONJ
admet-628	236	25	4	4	NUM
admet-628	236	26	)	)	PUNCT
admet-628	236	27	,	,	PUNCT
admet-628	236	28	and	and	CCONJ
admet-628	236	29	muscle	muscle	NOUN
admet-628	236	30	(	(	PUNCT
admet-628	236	31	data	datum	NOUN
admet-628	236	32	not	not	PART
admet-628	236	33	admet	admet	PROPN
admet-628	236	34	&	&	CCONJ
admet-628	236	35	dmpk	dmpk	PROPN
admet-628	236	36	7(1	7(1	PROPN
admet-628	236	37	)	)	PUNCT
admet-628	236	38	(	(	PUNCT
admet-628	236	39	2019	2019	NUM
admet-628	236	40	)	)	PUNCT
admet-628	236	41	22	22	NUM
admet-628	236	42	-	-	SYM
admet-628	236	43	43	43	NUM
admet-628	236	44	a	a	DET
admet-628	236	45	physiologically	physiologically	ADV
admet-628	236	46	-	-	PUNCT
admet-628	236	47	based	base	VERB
admet-628	236	48	pharmacokinetic	pharmacokinetic	ADJ
admet-628	236	49	model	model	NOUN
admet-628	236	50	for	for	ADP
admet-628	236	51	oseltamivir	oseltamivir	PROPN
admet-628	236	52	doi	doi	PROPN
admet-628	236	53	:	:	PUNCT
admet-628	236	54	10.5599	10.5599	NUM
admet-628	236	55	/	/	SYM
admet-628	236	56	admet.628	admet.628	PROPN
admet-628	236	57	31	31	NUM
admet-628	236	58	shown	show	VERB
admet-628	236	59	)	)	PUNCT
admet-628	236	60	.	.	PUNCT
admet-628	237	1	the	the	DET
admet-628	237	2	auc0	auc0	PROPN
admet-628	237	3	-	-	PUNCT
admet-628	237	4	4h	4h	PROPN
admet-628	237	5	of	of	ADP
admet-628	237	6	oc	oc	NOUN
admet-628	237	7	in	in	ADP
admet-628	237	8	the	the	DET
admet-628	237	9	lungs	lung	NOUN
admet-628	237	10	were	be	AUX
admet-628	237	11	5.2	5.2	NUM
admet-628	237	12	and	and	CCONJ
admet-628	237	13	26.1	26.1	NUM
admet-628	237	14	µg·h	µg·h	NUM
admet-628	237	15	/	/	SYM
admet-628	237	16	ml	ml	NOUN
admet-628	237	17	,	,	PUNCT
admet-628	237	18	respectively	respectively	ADV
admet-628	237	19	when	when	SCONJ
admet-628	237	20	rats	rat	NOUN
admet-628	237	21	were	be	AUX
admet-628	237	22	treated	treat	VERB
admet-628	237	23	with	with	ADP
admet-628	237	24	an	an	DET
admet-628	237	25	oral	oral	ADJ
admet-628	237	26	dose	dose	NOUN
admet-628	237	27	of	of	ADP
admet-628	237	28	10	10	NUM
admet-628	237	29	mg	mg	NUM
admet-628	237	30	/	/	SYM
admet-628	237	31	kg	kg	PROPN
admet-628	237	32	and	and	CCONJ
admet-628	237	33	50	50	NUM
admet-628	237	34	mg	mg	NUM
admet-628	237	35	/	/	SYM
admet-628	237	36	kg	kg	NOUN
admet-628	237	37	op	op	NOUN
admet-628	237	38	.	.	PUNCT
admet-628	238	1	these	these	DET
admet-628	238	2	results	result	NOUN
admet-628	238	3	showed	show	VERB
admet-628	238	4	that	that	SCONJ
admet-628	238	5	the	the	DET
admet-628	238	6	dose	dose	NOUN
admet-628	238	7	of	of	ADP
admet-628	238	8	oc	oc	PRON
admet-628	238	9	delivered	deliver	VERB
admet-628	238	10	to	to	ADP
admet-628	238	11	the	the	DET
admet-628	238	12	lungs	lung	NOUN
admet-628	238	13	increased	increase	VERB
admet-628	238	14	in	in	ADP
admet-628	238	15	proportion	proportion	NOUN
admet-628	238	16	to	to	ADP
admet-628	238	17	the	the	DET
admet-628	238	18	op	op	NOUN
admet-628	238	19	dose	dose	NOUN
admet-628	238	20	applied	apply	VERB
admet-628	238	21	externally	externally	ADV
admet-628	238	22	,	,	PUNCT
admet-628	238	23	a	a	DET
admet-628	238	24	finding	finding	NOUN
admet-628	238	25	which	which	PRON
admet-628	238	26	was	be	AUX
admet-628	238	27	consistent	consistent	ADJ
admet-628	238	28	with	with	ADP
admet-628	238	29	the	the	DET
admet-628	238	30	assumption	assumption	NOUN
admet-628	238	31	of	of	ADP
admet-628	238	32	linear	linear	ADJ
admet-628	238	33	kinetics	kinetic	NOUN
admet-628	238	34	in	in	ADP
admet-628	238	35	the	the	DET
admet-628	238	36	pbpk	pbpk	ADJ
admet-628	238	37	model	model	NOUN
admet-628	238	38	.	.	PUNCT
admet-628	239	1	(	(	PUNCT
admet-628	239	2	a	a	X
admet-628	239	3	)	)	PUNCT
admet-628	239	4	liver	liver	NOUN
admet-628	239	5	(	(	PUNCT
admet-628	239	6	b	b	NOUN
admet-628	239	7	)	)	PUNCT
admet-628	239	8	kidney	kidney	NOUN
admet-628	239	9	(	(	PUNCT
admet-628	239	10	c	c	NOUN
admet-628	239	11	)	)	PUNCT
admet-628	239	12	lung	lung	NOUN
admet-628	239	13	(	(	PUNCT
admet-628	239	14	d	d	NOUN
admet-628	239	15	)	)	PUNCT
admet-628	239	16	plasma	plasma	NOUN
admet-628	239	17	(	(	PUNCT
admet-628	239	18	e	e	NOUN
admet-628	239	19	)	)	PUNCT
admet-628	239	20	brain	brain	NOUN
admet-628	239	21	figure	figure	NOUN
admet-628	239	22	3	3	NUM
admet-628	239	23	.	.	NOUN
admet-628	239	24	time	time	NOUN
admet-628	239	25	course	course	NOUN
admet-628	239	26	of	of	ADP
admet-628	239	27	op	op	NOUN
admet-628	239	28	and	and	CCONJ
admet-628	239	29	oc	oc	ADP
admet-628	239	30	concentrations	concentration	NOUN
admet-628	239	31	in	in	ADP
admet-628	239	32	the	the	DET
admet-628	239	33	plasma	plasma	NOUN
admet-628	239	34	and	and	CCONJ
admet-628	239	35	tissues	tissue	NOUN
admet-628	239	36	of	of	ADP
admet-628	239	37	rats	rat	NOUN
admet-628	239	38	after	after	ADP
admet-628	239	39	administering	administer	VERB
admet-628	239	40	a	a	DET
admet-628	239	41	single	single	ADJ
admet-628	239	42	oral	oral	ADJ
admet-628	239	43	dose	dose	NOUN
admet-628	239	44	of	of	ADP
admet-628	239	45	10	10	NUM
admet-628	239	46	mg	mg	NUM
admet-628	239	47	/	/	SYM
admet-628	239	48	kg	kg	NOUN
admet-628	239	49	op	op	NOUN
admet-628	239	50	.	.	PUNCT
admet-628	240	1	(	(	PUNCT
admet-628	240	2	a	a	X
admet-628	240	3	)	)	PUNCT
admet-628	240	4	liver	liver	NOUN
admet-628	240	5	,	,	PUNCT
admet-628	240	6	(	(	PUNCT
admet-628	240	7	b	b	X
admet-628	240	8	)	)	PUNCT
admet-628	240	9	kidney	kidney	NOUN
admet-628	240	10	,	,	PUNCT
admet-628	240	11	(	(	PUNCT
admet-628	240	12	c	c	NOUN
admet-628	240	13	)	)	PUNCT
admet-628	240	14	lung	lung	NOUN
admet-628	240	15	,	,	PUNCT
admet-628	240	16	(	(	PUNCT
admet-628	240	17	d	d	NOUN
admet-628	240	18	)	)	PUNCT
admet-628	240	19	plasma	plasma	NOUN
admet-628	240	20	,	,	PUNCT
admet-628	240	21	(	(	PUNCT
admet-628	240	22	e	e	NOUN
admet-628	240	23	)	)	PUNCT
admet-628	240	24	brain	brain	NOUN
admet-628	240	25	.	.	PUNCT
admet-628	241	1	data	datum	NOUN
admet-628	241	2	points	point	NOUN
admet-628	241	3	,	,	PUNCT
admet-628	241	4	means	mean	VERB
admet-628	241	5	+	+	X
admet-628	242	1	s.d	s.d	PROPN
admet-628	242	2	.	.	PROPN
admet-628	242	3	of	of	ADP
admet-628	242	4	the	the	DET
admet-628	242	5	experimental	experimental	ADJ
admet-628	242	6	plasma	plasma	NOUN
admet-628	242	7	/	/	SYM
admet-628	242	8	tissue	tissue	NOUN
admet-628	242	9	concentrations	concentration	NOUN
admet-628	242	10	from	from	ADP
admet-628	242	11	three	three	NUM
admet-628	242	12	different	different	ADJ
admet-628	242	13	rats	rat	NOUN
admet-628	242	14	;	;	PUNCT
admet-628	242	15	(	(	PUNCT
admet-628	243	1	_	_	PUNCT
admet-628	243	2	_	_	PUNCT
admet-628	244	1	_	_	PUNCT
admet-628	244	2	)	)	PUNCT
admet-628	244	3	model	model	NOUN
admet-628	244	4	-	-	PUNCT
admet-628	244	5	simulated	simulate	VERB
admet-628	244	6	op	op	NOUN
admet-628	244	7	concentrations	concentration	NOUN
admet-628	244	8	;	;	PUNCT
admet-628	244	9	(	(	PUNCT
admet-628	244	10	—	—	PUNCT
admet-628	244	11	—	—	PUNCT
admet-628	244	12	)	)	PUNCT
admet-628	244	13	model	model	NOUN
admet-628	244	14	-	-	PUNCT
admet-628	244	15	simulated	simulate	VERB
admet-628	244	16	oc	oc	NOUN
admet-628	244	17	concentrations	concentration	NOUN
admet-628	244	18	g.	g.	PROPN
admet-628	244	19	gao	gao	PROPN
admet-628	244	20	et	et	PROPN
admet-628	244	21	al	al	PROPN
admet-628	244	22	.	.	PROPN
admet-628	244	23	admet	admet	PROPN
admet-628	244	24	&	&	CCONJ
admet-628	244	25	dmpk	dmpk	PROPN
admet-628	244	26	7(1	7(1	PROPN
admet-628	244	27	)	)	PUNCT
admet-628	244	28	(	(	PUNCT
admet-628	244	29	2019	2019	NUM
admet-628	244	30	)	)	PUNCT
admet-628	244	31	22	22	NUM
admet-628	244	32	-	-	SYM
admet-628	244	33	43	43	NUM
admet-628	244	34	32	32	NUM
admet-628	244	35	(	(	PUNCT
admet-628	244	36	a	a	NOUN
admet-628	244	37	)	)	PUNCT
admet-628	244	38	liver	liver	NOUN
admet-628	244	39	(	(	PUNCT
admet-628	244	40	b	b	NOUN
admet-628	244	41	)	)	PUNCT
admet-628	244	42	kidney	kidney	NOUN
admet-628	244	43	(	(	PUNCT
admet-628	244	44	c	c	NOUN
admet-628	244	45	)	)	PUNCT
admet-628	244	46	lung	lung	NOUN
admet-628	244	47	(	(	PUNCT
admet-628	244	48	d	d	NOUN
admet-628	244	49	)	)	PUNCT
admet-628	244	50	plasma	plasma	NOUN
admet-628	244	51	(	(	PUNCT
admet-628	244	52	e	e	NOUN
admet-628	244	53	)	)	PUNCT
admet-628	244	54	brain	brain	NOUN
admet-628	244	55	figure	figure	NOUN
admet-628	244	56	4	4	NUM
admet-628	244	57	.	.	NOUN
admet-628	244	58	time	time	NOUN
admet-628	244	59	course	course	NOUN
admet-628	244	60	of	of	ADP
admet-628	244	61	op	op	NOUN
admet-628	244	62	and	and	CCONJ
admet-628	244	63	oc	oc	ADP
admet-628	244	64	concentrations	concentration	NOUN
admet-628	244	65	in	in	ADP
admet-628	244	66	the	the	DET
admet-628	244	67	plasma	plasma	NOUN
admet-628	244	68	and	and	CCONJ
admet-628	244	69	tissues	tissue	NOUN
admet-628	244	70	of	of	ADP
admet-628	244	71	rats	rat	NOUN
admet-628	244	72	after	after	ADP
admet-628	244	73	administering	administer	VERB
admet-628	244	74	a	a	DET
admet-628	244	75	single	single	ADJ
admet-628	244	76	oral	oral	ADJ
admet-628	244	77	dose	dose	NOUN
admet-628	244	78	of	of	ADP
admet-628	244	79	50	50	NUM
admet-628	244	80	mg	mg	NUM
admet-628	244	81	/	/	SYM
admet-628	244	82	kg	kg	NOUN
admet-628	244	83	op	op	NOUN
admet-628	244	84	.	.	PUNCT
admet-628	245	1	(	(	PUNCT
admet-628	245	2	a	a	X
admet-628	245	3	)	)	PUNCT
admet-628	245	4	liver	liver	NOUN
admet-628	245	5	,	,	PUNCT
admet-628	245	6	(	(	PUNCT
admet-628	245	7	b	b	X
admet-628	245	8	)	)	PUNCT
admet-628	245	9	kidney	kidney	NOUN
admet-628	245	10	,	,	PUNCT
admet-628	245	11	(	(	PUNCT
admet-628	245	12	c	c	NOUN
admet-628	245	13	)	)	PUNCT
admet-628	245	14	lung	lung	NOUN
admet-628	245	15	,	,	PUNCT
admet-628	245	16	(	(	PUNCT
admet-628	245	17	d	d	NOUN
admet-628	245	18	)	)	PUNCT
admet-628	245	19	plasma	plasma	NOUN
admet-628	245	20	,	,	PUNCT
admet-628	245	21	(	(	PUNCT
admet-628	245	22	e	e	NOUN
admet-628	245	23	)	)	PUNCT
admet-628	245	24	brain	brain	NOUN
admet-628	245	25	.	.	PUNCT
admet-628	246	1	data	datum	NOUN
admet-628	246	2	points	point	NOUN
admet-628	246	3	,	,	PUNCT
admet-628	246	4	means	mean	VERB
admet-628	246	5	+	+	X
admet-628	247	1	s.d	s.d	PROPN
admet-628	247	2	.	.	PROPN
admet-628	247	3	of	of	ADP
admet-628	247	4	the	the	DET
admet-628	247	5	experimental	experimental	ADJ
admet-628	247	6	plasma	plasma	NOUN
admet-628	247	7	/	/	SYM
admet-628	247	8	tissue	tissue	NOUN
admet-628	247	9	concentrations	concentration	NOUN
admet-628	247	10	from	from	ADP
admet-628	247	11	three	three	NUM
admet-628	247	12	different	different	ADJ
admet-628	247	13	rats	rat	NOUN
admet-628	247	14	;	;	PUNCT
admet-628	247	15	(	(	PUNCT
admet-628	248	1	_	_	PUNCT
admet-628	248	2	_	_	PUNCT
admet-628	249	1	_	_	PUNCT
admet-628	249	2	)	)	PUNCT
admet-628	249	3	model	model	NOUN
admet-628	249	4	-	-	PUNCT
admet-628	249	5	simulated	simulate	VERB
admet-628	249	6	op	op	NOUN
admet-628	249	7	concentrations	concentration	NOUN
admet-628	249	8	;	;	PUNCT
admet-628	249	9	(	(	PUNCT
admet-628	249	10	—	—	PUNCT
admet-628	249	11	—	—	PUNCT
admet-628	249	12	)	)	PUNCT
admet-628	249	13	model	model	NOUN
admet-628	249	14	-	-	PUNCT
admet-628	249	15	simulated	simulate	VERB
admet-628	249	16	oc	oc	NOUN
admet-628	249	17	concentrations	concentration	NOUN
admet-628	249	18	the	the	DET
admet-628	249	19	rat	rat	NOUN
admet-628	249	20	pbpk	pbpk	NOUN
admet-628	249	21	model	model	NOUN
admet-628	249	22	was	be	AUX
admet-628	249	23	developed	develop	VERB
admet-628	249	24	based	base	VERB
admet-628	249	25	on	on	ADP
admet-628	249	26	the	the	DET
admet-628	249	27	experimental	experimental	ADJ
admet-628	249	28	data	datum	NOUN
admet-628	249	29	of	of	ADP
admet-628	249	30	the	the	DET
admet-628	249	31	10	10	NUM
admet-628	249	32	mg	mg	PROPN
admet-628	249	33	/	/	SYM
admet-628	249	34	kg	kg	PROPN
admet-628	249	35	treated	treat	VERB
admet-628	249	36	rats	rat	NOUN
admet-628	249	37	(	(	PUNCT
admet-628	249	38	fig	fig	NOUN
admet-628	249	39	.	.	PUNCT
admet-628	250	1	3	3	NUM
admet-628	250	2	)	)	PUNCT
admet-628	250	3	.	.	PUNCT
admet-628	251	1	it	it	PRON
admet-628	251	2	was	be	AUX
admet-628	251	3	subsequently	subsequently	ADV
admet-628	251	4	validated	validate	VERB
admet-628	251	5	using	use	VERB
admet-628	251	6	the	the	DET
admet-628	251	7	experimental	experimental	ADJ
admet-628	251	8	data	datum	NOUN
admet-628	251	9	of	of	ADP
admet-628	251	10	the	the	DET
admet-628	251	11	50	50	NUM
admet-628	251	12	mg	mg	PROPN
admet-628	251	13	/	/	SYM
admet-628	251	14	kg	kg	PROPN
admet-628	251	15	treated	treat	VERB
admet-628	251	16	rats	rat	NOUN
admet-628	251	17	(	(	PUNCT
admet-628	251	18	fig	fig	NOUN
admet-628	251	19	.	.	PUNCT
admet-628	252	1	4	4	NUM
admet-628	252	2	)	)	PUNCT
admet-628	252	3	.	.	PUNCT
admet-628	253	1	in	in	ADP
admet-628	253	2	order	order	NOUN
admet-628	253	3	to	to	PART
admet-628	253	4	fit	fit	VERB
admet-628	253	5	the	the	DET
admet-628	253	6	experimental	experimental	ADJ
admet-628	253	7	data	datum	NOUN
admet-628	253	8	well	well	ADV
admet-628	253	9	,	,	PUNCT
admet-628	253	10	however	however	ADV
admet-628	253	11	,	,	PUNCT
admet-628	253	12	the	the	DET
admet-628	253	13	ka	ka	PROPN
admet-628	253	14	and	and	CCONJ
admet-628	253	15	f	f	PROPN
admet-628	253	16	values	value	NOUN
admet-628	253	17	of	of	ADP
admet-628	253	18	the	the	DET
admet-628	253	19	pbpk	pbpk	ADJ
admet-628	253	20	model	model	NOUN
admet-628	253	21	for	for	ADP
admet-628	253	22	the	the	DET
admet-628	253	23	50	50	NUM
admet-628	253	24	mg	mg	PROPN
admet-628	253	25	/	/	SYM
admet-628	253	26	kg	kg	PROPN
admet-628	253	27	treated	treat	VERB
admet-628	253	28	rats	rat	NOUN
admet-628	253	29	had	have	VERB
admet-628	253	30	to	to	PART
admet-628	253	31	be	be	AUX
admet-628	253	32	higher	high	ADJ
admet-628	253	33	than	than	ADP
admet-628	253	34	those	those	PRON
admet-628	253	35	of	of	ADP
admet-628	253	36	the	the	DET
admet-628	253	37	10	10	NUM
admet-628	253	38	mg	mg	PROPN
admet-628	253	39	/	/	SYM
admet-628	253	40	kg	kg	PROPN
admet-628	253	41	treated	treat	VERB
admet-628	253	42	rats	rat	NOUN
admet-628	253	43	,	,	PUNCT
admet-628	253	44	suggesting	suggest	VERB
admet-628	253	45	that	that	SCONJ
admet-628	253	46	op	op	NOUN
admet-628	253	47	absorption	absorption	NOUN
admet-628	253	48	was	be	AUX
admet-628	253	49	more	more	ADV
admet-628	253	50	rapid	rapid	ADJ
admet-628	253	51	and	and	CCONJ
admet-628	253	52	extensive	extensive	ADJ
admet-628	253	53	in	in	ADP
admet-628	253	54	the	the	DET
admet-628	253	55	50	50	NUM
admet-628	253	56	mg	mg	NUM
admet-628	253	57	/	/	SYM
admet-628	253	58	kg	kg	PROPN
admet-628	253	59	treated	treat	VERB
admet-628	253	60	rats	rat	NOUN
admet-628	253	61	than	than	SCONJ
admet-628	253	62	the	the	DET
admet-628	253	63	10	10	NUM
admet-628	253	64	mg	mg	NUM
admet-628	253	65	/	/	SYM
admet-628	253	66	kg	kg	PROPN
admet-628	253	67	treated	treat	VERB
admet-628	253	68	rats	rat	NOUN
admet-628	253	69	(	(	PUNCT
admet-628	253	70	table	table	NOUN
admet-628	253	71	2	2	NUM
admet-628	253	72	)	)	PUNCT
admet-628	253	73	.	.	PUNCT
admet-628	254	1	the	the	DET
admet-628	254	2	rat	rat	NOUN
admet-628	254	3	pbpk	pbpk	NOUN
admet-628	254	4	model	model	NOUN
admet-628	254	5	was	be	AUX
admet-628	254	6	also	also	ADV
admet-628	254	7	validated	validate	VERB
admet-628	254	8	using	use	VERB
admet-628	254	9	the	the	DET
admet-628	254	10	plasma	plasma	NOUN
admet-628	254	11	oc	oc	ADP
admet-628	254	12	concentration	concentration	NOUN
admet-628	254	13	-	-	PUNCT
admet-628	254	14	time	time	NOUN
admet-628	254	15	data	datum	NOUN
admet-628	254	16	reported	report	VERB
admet-628	254	17	by	by	ADP
admet-628	254	18	eisenberg	eisenberg	PROPN
admet-628	254	19	et	et	PROPN
admet-628	254	20	al	al	PROPN
admet-628	254	21	.	.	PUNCT
admet-628	255	1	[	[	X
admet-628	255	2	37	37	NUM
admet-628	255	3	]	]	PUNCT
admet-628	255	4	.	.	PUNCT
admet-628	256	1	the	the	DET
admet-628	256	2	rat	rat	NOUN
admet-628	256	3	pbpk	pbpk	NOUN
admet-628	256	4	model	model	NOUN
admet-628	256	5	was	be	AUX
admet-628	256	6	able	able	ADJ
admet-628	256	7	to	to	PART
admet-628	256	8	predict	predict	VERB
admet-628	256	9	accurately	accurately	ADV
admet-628	256	10	the	the	DET
admet-628	256	11	experimental	experimental	ADJ
admet-628	256	12	data	datum	NOUN
admet-628	256	13	(	(	PUNCT
admet-628	256	14	fig	fig	NOUN
admet-628	256	15	.	.	PUNCT
admet-628	256	16	5	5	NUM
admet-628	256	17	)	)	PUNCT
admet-628	256	18	and	and	CCONJ
admet-628	256	19	the	the	DET
admet-628	256	20	tissue	tissue	NOUN
admet-628	256	21	distribution	distribution	NOUN
admet-628	256	22	data	datum	NOUN
admet-628	256	23	of	of	ADP
admet-628	256	24	the	the	DET
admet-628	256	25	10	10	NUM
admet-628	256	26	mg	mg	PROPN
admet-628	256	27	/	/	SYM
admet-628	256	28	kg	kg	VERB
admet-628	256	29	-	-	PUNCT
admet-628	256	30	treated	treat	VERB
admet-628	256	31	(	(	PUNCT
admet-628	256	32	fig	fig	NOUN
admet-628	256	33	.	.	PUNCT
admet-628	257	1	3	3	NUM
admet-628	257	2	)	)	PUNCT
admet-628	257	3	and	and	CCONJ
admet-628	257	4	50	50	NUM
admet-628	257	5	mg	mg	NUM
admet-628	257	6	/	/	SYM
admet-628	257	7	kg	kg	VERB
admet-628	257	8	-	-	PUNCT
admet-628	257	9	treated	treat	VERB
admet-628	257	10	rats	rat	NOUN
admet-628	257	11	(	(	PUNCT
admet-628	257	12	fig	fig	NOUN
admet-628	257	13	.	.	PUNCT
admet-628	257	14	4	4	NUM
admet-628	257	15	)	)	PUNCT
admet-628	257	16	.	.	PUNCT
admet-628	258	1	the	the	DET
admet-628	258	2	pbpk	pbpk	PROPN
admet-628	258	3	model	model	NOUN
admet-628	258	4	also	also	ADV
admet-628	258	5	was	be	AUX
admet-628	258	6	used	use	VERB
admet-628	258	7	to	to	PART
admet-628	258	8	simulate	simulate	VERB
admet-628	258	9	the	the	DET
admet-628	258	10	kinetic	kinetic	ADJ
admet-628	258	11	profiles	profile	NOUN
admet-628	258	12	of	of	ADP
admet-628	258	13	op	op	NOUN
admet-628	258	14	/	/	SYM
admet-628	258	15	oc	oc	NOUN
admet-628	258	16	in	in	ADP
admet-628	258	17	the	the	DET
admet-628	258	18	rat	rat	NOUN
admet-628	258	19	’s	’s	PART
admet-628	258	20	brain	brain	NOUN
admet-628	258	21	(	(	PUNCT
admet-628	258	22	figs	fig	NOUN
admet-628	258	23	.	.	PUNCT
admet-628	259	1	3e	3e	NOUN
admet-628	259	2	and	and	CCONJ
admet-628	259	3	4e	4e	PROPN
admet-628	259	4	)	)	PUNCT
admet-628	259	5	.	.	PUNCT
admet-628	260	1	for	for	ADP
admet-628	260	2	rats	rat	NOUN
admet-628	260	3	dosed	dose	VERB
admet-628	260	4	with	with	ADP
admet-628	260	5	10	10	NUM
admet-628	260	6	mg	mg	NUM
admet-628	260	7	/	/	SYM
admet-628	260	8	kg	kg	NOUN
admet-628	260	9	op	op	NOUN
admet-628	260	10	,	,	PUNCT
admet-628	260	11	admet	admet	PROPN
admet-628	260	12	&	&	CCONJ
admet-628	260	13	dmpk	dmpk	PROPN
admet-628	260	14	7(1	7(1	PROPN
admet-628	260	15	)	)	PUNCT
admet-628	260	16	(	(	PUNCT
admet-628	260	17	2019	2019	NUM
admet-628	260	18	)	)	PUNCT
admet-628	260	19	22	22	NUM
admet-628	260	20	-	-	SYM
admet-628	260	21	43	43	NUM
admet-628	260	22	a	a	DET
admet-628	260	23	physiologically	physiologically	ADV
admet-628	260	24	-	-	PUNCT
admet-628	260	25	based	base	VERB
admet-628	260	26	pharmacokinetic	pharmacokinetic	ADJ
admet-628	260	27	model	model	NOUN
admet-628	260	28	for	for	ADP
admet-628	260	29	oseltamivir	oseltamivir	PROPN
admet-628	260	30	doi	doi	PROPN
admet-628	260	31	:	:	PUNCT
admet-628	260	32	10.5599	10.5599	NUM
admet-628	260	33	/	/	SYM
admet-628	260	34	admet.628	admet.628	PROPN
admet-628	260	35	33	33	NUM
admet-628	260	36	the	the	DET
admet-628	260	37	predicted	predict	VERB
admet-628	260	38	cmax	cmax	NOUN
admet-628	260	39	for	for	ADP
admet-628	260	40	op	op	NOUN
admet-628	260	41	and	and	CCONJ
admet-628	260	42	oc	oc	NOUN
admet-628	260	43	in	in	ADP
admet-628	260	44	the	the	DET
admet-628	260	45	brain	brain	NOUN
admet-628	260	46	were	be	AUX
admet-628	260	47	1.25	1.25	NUM
admet-628	260	48	µg	µg	NOUN
admet-628	260	49	/	/	SYM
admet-628	260	50	g	g	NOUN
admet-628	260	51	and	and	CCONJ
admet-628	260	52	0.34	0.34	NUM
admet-628	260	53	µg	µg	ADJ
admet-628	260	54	/	/	SYM
admet-628	260	55	g	g	NOUN
admet-628	260	56	,	,	PUNCT
admet-628	260	57	respectively	respectively	ADV
admet-628	260	58	.	.	PUNCT
admet-628	261	1	for	for	ADP
admet-628	261	2	rats	rat	NOUN
admet-628	261	3	dosed	dose	VERB
admet-628	261	4	with	with	ADP
admet-628	261	5	50	50	NUM
admet-628	261	6	mg	mg	NUM
admet-628	261	7	/	/	SYM
admet-628	261	8	kg	kg	NOUN
admet-628	261	9	op	op	NOUN
admet-628	261	10	,	,	PUNCT
admet-628	261	11	the	the	DET
admet-628	261	12	predicted	predict	VERB
admet-628	261	13	cmax	cmax	NOUN
admet-628	261	14	for	for	ADP
admet-628	261	15	op	op	NOUN
admet-628	261	16	and	and	CCONJ
admet-628	261	17	oc	oc	NOUN
admet-628	261	18	were	be	AUX
admet-628	261	19	6.64	6.64	NUM
admet-628	261	20	µg	µg	NOUN
admet-628	261	21	/	/	SYM
admet-628	261	22	g	g	NOUN
admet-628	261	23	and	and	CCONJ
admet-628	261	24	1.65	1.65	NUM
admet-628	261	25	µg	µg	NOUN
admet-628	261	26	/	/	SYM
admet-628	261	27	g	g	NOUN
admet-628	261	28	,	,	PUNCT
admet-628	261	29	respectively	respectively	ADV
admet-628	261	30	.	.	PUNCT
admet-628	262	1	these	these	DET
admet-628	262	2	results	result	NOUN
admet-628	262	3	were	be	AUX
admet-628	262	4	in	in	ADP
admet-628	262	5	agreement	agreement	NOUN
admet-628	262	6	with	with	ADP
admet-628	262	7	the	the	DET
admet-628	262	8	other	other	ADJ
admet-628	262	9	rat	rat	NOUN
admet-628	262	10	tissue	tissue	NOUN
admet-628	262	11	/	/	SYM
admet-628	262	12	organs	organ	NOUN
admet-628	262	13	in	in	ADP
admet-628	262	14	which	which	PRON
admet-628	262	15	op	op	NOUN
admet-628	262	16	/	/	SYM
admet-628	262	17	oc	oc	NOUN
admet-628	262	18	tissue	tissue	NOUN
admet-628	262	19	doses	dose	NOUN
admet-628	262	20	were	be	AUX
admet-628	262	21	found	find	VERB
admet-628	262	22	to	to	PART
admet-628	262	23	increase	increase	VERB
admet-628	262	24	linearly	linearly	ADV
admet-628	262	25	with	with	ADP
admet-628	262	26	the	the	DET
admet-628	262	27	applied	apply	VERB
admet-628	262	28	op	op	NOUN
admet-628	262	29	dose	dose	NOUN
admet-628	262	30	(	(	PUNCT
admet-628	262	31	figs	fig	NOUN
admet-628	262	32	.	.	X
admet-628	263	1	3	3	NUM
admet-628	263	2	and	and	CCONJ
admet-628	263	3	4	4	NUM
admet-628	263	4	)	)	PUNCT
admet-628	263	5	.	.	PUNCT
admet-628	264	1	we	we	PRON
admet-628	264	2	also	also	ADV
admet-628	264	3	performed	perform	VERB
admet-628	264	4	route	route	NOUN
admet-628	264	5	-	-	PUNCT
admet-628	264	6	to	to	ADP
admet-628	264	7	-	-	PUNCT
admet-628	264	8	route	route	NOUN
admet-628	264	9	extrapolation	extrapolation	NOUN
admet-628	264	10	by	by	ADP
admet-628	264	11	comparing	compare	VERB
admet-628	264	12	model	model	NOUN
admet-628	264	13	simulation	simulation	NOUN
admet-628	264	14	with	with	ADP
admet-628	264	15	the	the	DET
admet-628	264	16	experimental	experimental	ADJ
admet-628	264	17	data	datum	NOUN
admet-628	264	18	reported	report	VERB
admet-628	264	19	by	by	ADP
admet-628	264	20	eisenberg	eisenberg	PROPN
admet-628	264	21	et	et	PROPN
admet-628	264	22	al	al	PROPN
admet-628	264	23	.	.	PUNCT
admet-628	265	1	[	[	X
admet-628	265	2	37	37	NUM
admet-628	265	3	]	]	PUNCT
admet-628	265	4	.	.	PUNCT
admet-628	266	1	the	the	DET
admet-628	266	2	pbpk	pbpk	PROPN
admet-628	266	3	model	model	NOUN
admet-628	266	4	was	be	AUX
admet-628	266	5	able	able	ADJ
admet-628	266	6	to	to	PART
admet-628	266	7	describe	describe	VERB
admet-628	266	8	closely	closely	ADV
admet-628	266	9	the	the	DET
admet-628	266	10	plasma	plasma	NOUN
admet-628	266	11	op	op	NOUN
admet-628	266	12	/	/	SYM
admet-628	266	13	oc	oc	NOUN
admet-628	266	14	concentration	concentration	NOUN
admet-628	266	15	-	-	PUNCT
admet-628	266	16	time	time	NOUN
admet-628	266	17	profiles	profile	NOUN
admet-628	266	18	of	of	ADP
admet-628	266	19	rats	rat	NOUN
admet-628	266	20	receiving	receive	VERB
admet-628	266	21	either	either	CCONJ
admet-628	266	22	a	a	DET
admet-628	266	23	single	single	ADJ
admet-628	266	24	dose	dose	NOUN
admet-628	266	25	of	of	ADP
admet-628	266	26	30	30	NUM
admet-628	266	27	mg	mg	PROPN
admet-628	266	28	/	/	SYM
admet-628	266	29	kg	kg	NOUN
admet-628	266	30	op	op	NOUN
admet-628	266	31	orally	orally	ADV
admet-628	266	32	or	or	CCONJ
admet-628	266	33	an	an	DET
admet-628	266	34	i.v	i.v	PROPN
admet-628	266	35	.	.	PUNCT
admet-628	267	1	infusion	infusion	NOUN
admet-628	267	2	of	of	ADP
admet-628	267	3	30	30	NUM
admet-628	267	4	mg	mg	PROPN
admet-628	267	5	/	/	SYM
admet-628	267	6	kg	kg	NOUN
admet-628	267	7	oc	oc	X
admet-628	267	8	(	(	PUNCT
admet-628	267	9	fig	fig	NOUN
admet-628	267	10	.	.	PUNCT
admet-628	267	11	5	5	NUM
admet-628	267	12	)	)	PUNCT
admet-628	267	13	.	.	PUNCT
admet-628	268	1	sensitivity	sensitivity	NOUN
admet-628	268	2	analysis	analysis	NOUN
admet-628	268	3	of	of	ADP
admet-628	268	4	rat	rat	NOUN
admet-628	268	5	pbpk	pbpk	NOUN
admet-628	268	6	model	model	NOUN
admet-628	268	7	the	the	DET
admet-628	268	8	sensitivity	sensitivity	NOUN
admet-628	268	9	analysis	analysis	NOUN
admet-628	268	10	provided	provide	VERB
admet-628	268	11	a	a	DET
admet-628	268	12	quantitative	quantitative	ADJ
admet-628	268	13	means	mean	NOUN
admet-628	268	14	to	to	PART
admet-628	268	15	evaluate	evaluate	VERB
admet-628	268	16	how	how	SCONJ
admet-628	268	17	the	the	DET
admet-628	268	18	various	various	ADJ
admet-628	268	19	input	input	NOUN
admet-628	268	20	parameters	parameter	NOUN
admet-628	268	21	might	might	AUX
admet-628	268	22	affect	affect	VERB
admet-628	268	23	the	the	DET
admet-628	268	24	oc	oc	NOUN
admet-628	268	25	dose	dose	NOUN
admet-628	268	26	metrics	metric	NOUN
admet-628	268	27	in	in	ADP
admet-628	268	28	the	the	DET
admet-628	268	29	lungs	lung	NOUN
admet-628	268	30	and	and	CCONJ
admet-628	268	31	plasma	plasma	NOUN
admet-628	268	32	when	when	SCONJ
admet-628	268	33	the	the	DET
admet-628	268	34	rats	rat	NOUN
admet-628	268	35	were	be	AUX
admet-628	268	36	treated	treat	VERB
admet-628	268	37	with	with	ADP
admet-628	268	38	a	a	DET
admet-628	268	39	single	single	ADJ
admet-628	268	40	dose	dose	NOUN
admet-628	268	41	of	of	ADP
admet-628	268	42	10	10	NUM
admet-628	268	43	mg	mg	NUM
admet-628	268	44	/	/	SYM
admet-628	268	45	kg	kg	NOUN
admet-628	268	46	op	op	NOUN
admet-628	268	47	orally	orally	ADV
admet-628	268	48	.	.	PUNCT
admet-628	269	1	table	table	NOUN
admet-628	269	2	3	3	NUM
admet-628	269	3	shows	show	VERB
admet-628	269	4	a	a	DET
admet-628	269	5	summary	summary	NOUN
admet-628	269	6	of	of	ADP
admet-628	269	7	the	the	DET
admet-628	269	8	sensitivity	sensitivity	NOUN
admet-628	269	9	analysis	analysis	NOUN
admet-628	269	10	results	result	NOUN
admet-628	269	11	.	.	PUNCT
admet-628	270	1	the	the	DET
admet-628	270	2	sensitivity	sensitivity	NOUN
admet-628	270	3	coefficients	coefficient	NOUN
admet-628	270	4	were	be	AUX
admet-628	270	5	a	a	DET
admet-628	270	6	mix	mix	NOUN
admet-628	270	7	of	of	ADP
admet-628	270	8	positive	positive	ADJ
admet-628	270	9	and	and	CCONJ
admet-628	270	10	negative	negative	ADJ
admet-628	270	11	values	value	NOUN
admet-628	270	12	which	which	PRON
admet-628	270	13	varied	vary	VERB
admet-628	270	14	with	with	ADP
admet-628	270	15	time	time	NOUN
admet-628	270	16	over	over	ADP
admet-628	270	17	the	the	DET
admet-628	270	18	12	12	NUM
admet-628	270	19	h	h	NOUN
admet-628	270	20	post	post	ADJ
admet-628	270	21	-	-	ADJ
admet-628	270	22	dosing	dosing	ADJ
admet-628	270	23	period	period	NOUN
admet-628	270	24	.	.	PUNCT
admet-628	271	1	we	we	PRON
admet-628	271	2	arbitrarily	arbitrarily	ADV
admet-628	271	3	grouped	group	VERB
admet-628	271	4	the	the	DET
admet-628	271	5	parameters	parameter	NOUN
admet-628	271	6	into	into	ADP
admet-628	271	7	3	3	NUM
admet-628	271	8	different	different	ADJ
admet-628	271	9	categories	category	NOUN
admet-628	271	10	according	accord	VERB
admet-628	271	11	to	to	ADP
admet-628	271	12	their	their	PRON
admet-628	271	13	absolute	absolute	ADJ
admet-628	271	14	sensitivity	sensitivity	NOUN
admet-628	271	15	coefficients	coefficient	NOUN
admet-628	271	16	:	:	PUNCT
admet-628	271	17	high	high	ADJ
admet-628	271	18	(	(	PUNCT
admet-628	271	19	>	>	X
admet-628	271	20	0.5	0.5	NUM
admet-628	271	21	)	)	PUNCT
admet-628	271	22	,	,	PUNCT
admet-628	271	23	medium	medium	NOUN
admet-628	271	24	(	(	PUNCT
admet-628	271	25	0.2	0.2	NUM
admet-628	271	26	-	-	PUNCT
admet-628	271	27	0.5	0.5	NUM
admet-628	271	28	)	)	PUNCT
admet-628	271	29	,	,	PUNCT
admet-628	271	30	and	and	CCONJ
admet-628	271	31	low	low	ADJ
admet-628	271	32	(	(	PUNCT
admet-628	271	33	<	<	NOUN
admet-628	271	34	0.2	0.2	NUM
admet-628	271	35	)	)	PUNCT
admet-628	271	36	.	.	PUNCT
admet-628	272	1	based	base	VERB
admet-628	272	2	on	on	ADP
admet-628	272	3	these	these	DET
admet-628	272	4	groupings	grouping	NOUN
admet-628	272	5	,	,	PUNCT
admet-628	272	6	f	f	PROPN
admet-628	272	7	and	and	CCONJ
admet-628	272	8	tlag	tlag	NOUN
admet-628	272	9	were	be	AUX
admet-628	272	10	classified	classify	VERB
admet-628	272	11	as	as	ADP
admet-628	272	12	high	high	ADJ
admet-628	272	13	impact	impact	NOUN
admet-628	272	14	parameters	parameter	NOUN
admet-628	272	15	,	,	PUNCT
admet-628	272	16	km	km	PROPN
admet-628	272	17	and	and	CCONJ
admet-628	272	18	vmax	vmax	PROPN
admet-628	272	19	were	be	AUX
admet-628	272	20	classified	classify	VERB
admet-628	272	21	as	as	ADP
admet-628	272	22	medium	medium	ADJ
admet-628	272	23	impact	impact	NOUN
admet-628	272	24	parameters	parameter	NOUN
admet-628	272	25	,	,	PUNCT
admet-628	272	26	and	and	CCONJ
admet-628	272	27	clc	clc	PROPN
admet-628	272	28	,	,	PUNCT
admet-628	272	29	clp	clp	PROPN
admet-628	272	30	,	,	PUNCT
admet-628	272	31	ka	ka	PROPN
admet-628	272	32	and	and	CCONJ
admet-628	272	33	blplrp	blplrp	NOUN
admet-628	272	34	were	be	AUX
admet-628	272	35	classified	classify	VERB
admet-628	272	36	as	as	ADP
admet-628	272	37	low	low	ADJ
admet-628	272	38	impact	impact	NOUN
admet-628	272	39	parameters	parameter	NOUN
admet-628	272	40	for	for	ADP
admet-628	272	41	the	the	DET
admet-628	272	42	simulated	simulated	ADJ
admet-628	272	43	oc	oc	PART
admet-628	272	44	dose	dose	NOUN
admet-628	272	45	metrics	metric	NOUN
admet-628	272	46	in	in	ADP
admet-628	272	47	the	the	DET
admet-628	272	48	plasma	plasma	NOUN
admet-628	272	49	and	and	CCONJ
admet-628	272	50	lungs	lung	NOUN
admet-628	272	51	.	.	PUNCT
admet-628	273	1	interestingly	interestingly	ADV
admet-628	273	2	,	,	PUNCT
admet-628	273	3	blplrc	blplrc	PROPN
admet-628	273	4	had	have	VERB
admet-628	273	5	a	a	DET
admet-628	273	6	high	high	ADJ
admet-628	273	7	impact	impact	NOUN
admet-628	273	8	on	on	ADP
admet-628	273	9	the	the	DET
admet-628	273	10	plasma	plasma	NOUN
admet-628	273	11	dose	dose	NOUN
admet-628	273	12	metric	metric	NOUN
admet-628	273	13	but	but	CCONJ
admet-628	273	14	a	a	DET
admet-628	273	15	low	low	ADJ
admet-628	273	16	impact	impact	NOUN
admet-628	273	17	on	on	ADP
admet-628	273	18	the	the	DET
admet-628	273	19	pulmonary	pulmonary	NOUN
admet-628	273	20	dose	dose	NOUN
admet-628	273	21	metric	metric	NOUN
admet-628	273	22	.	.	PUNCT
admet-628	274	1	because	because	SCONJ
admet-628	274	2	the	the	DET
admet-628	274	3	f	f	PROPN
admet-628	274	4	value	value	NOUN
admet-628	274	5	was	be	AUX
admet-628	274	6	positive	positive	ADJ
admet-628	274	7	over	over	ADP
admet-628	274	8	the	the	DET
admet-628	274	9	12	12	NUM
admet-628	274	10	h	h	NOUN
admet-628	274	11	post	post	ADJ
admet-628	274	12	-	-	ADJ
admet-628	274	13	dosing	dosing	ADJ
admet-628	274	14	period	period	NOUN
admet-628	274	15	,	,	PUNCT
admet-628	274	16	oc	oc	SCONJ
admet-628	274	17	concentrations	concentration	NOUN
admet-628	274	18	in	in	ADP
admet-628	274	19	the	the	DET
admet-628	274	20	lung	lung	NOUN
admet-628	274	21	and	and	CCONJ
admet-628	274	22	plasma	plasma	NOUN
admet-628	274	23	would	would	AUX
admet-628	274	24	increase	increase	VERB
admet-628	274	25	with	with	ADP
admet-628	274	26	an	an	DET
admet-628	274	27	increasing	increase	VERB
admet-628	274	28	f	f	NOUN
admet-628	274	29	value	value	NOUN
admet-628	274	30	.	.	PUNCT
admet-628	275	1	because	because	SCONJ
admet-628	275	2	both	both	DET
admet-628	275	3	of	of	ADP
admet-628	275	4	the	the	DET
admet-628	275	5	clc	clc	PROPN
admet-628	275	6	and	and	CCONJ
admet-628	275	7	clp	clp	PROPN
admet-628	275	8	sensitivity	sensitivity	NOUN
admet-628	275	9	coefficients	coefficient	NOUN
admet-628	275	10	had	have	VERB
admet-628	275	11	negative	negative	ADJ
admet-628	275	12	values	value	NOUN
admet-628	275	13	,	,	PUNCT
admet-628	275	14	oc	oc	ADP
admet-628	275	15	concentrations	concentration	NOUN
admet-628	275	16	in	in	ADP
admet-628	275	17	the	the	DET
admet-628	275	18	lung	lung	NOUN
admet-628	275	19	and	and	CCONJ
admet-628	275	20	plasma	plasma	NOUN
admet-628	275	21	would	would	AUX
admet-628	275	22	decrease	decrease	VERB
admet-628	275	23	with	with	ADP
admet-628	275	24	increasing	increase	VERB
admet-628	275	25	clc	clc	PROPN
admet-628	275	26	and	and	CCONJ
admet-628	275	27	clp	clp	NOUN
admet-628	275	28	values	value	NOUN
admet-628	275	29	.	.	PUNCT
admet-628	276	1	(	(	PUNCT
admet-628	276	2	a	a	X
admet-628	276	3	)	)	PUNCT
admet-628	276	4	p.o	p.o	PROPN
admet-628	276	5	.	.	PROPN
admet-628	276	6	administration	administration	PROPN
admet-628	276	7	(	(	PUNCT
admet-628	276	8	b	b	NOUN
admet-628	276	9	)	)	PUNCT
admet-628	276	10	i.v	i.v	PROPN
admet-628	276	11	.	.	PUNCT
admet-628	277	1	injection	injection	NOUN
admet-628	277	2	figure	figure	NOUN
admet-628	277	3	5	5	NUM
admet-628	277	4	.	.	PUNCT
admet-628	278	1	plasma	plasma	NOUN
admet-628	278	2	oc	oc	ADP
admet-628	278	3	concentration	concentration	NOUN
admet-628	278	4	-	-	PUNCT
admet-628	278	5	time	time	NOUN
admet-628	278	6	profiles	profile	NOUN
admet-628	278	7	in	in	ADP
admet-628	278	8	rats	rat	NOUN
admet-628	278	9	after	after	ADP
admet-628	278	10	administering	administer	VERB
admet-628	278	11	(	(	PUNCT
admet-628	278	12	a	a	X
admet-628	278	13	)	)	PUNCT
admet-628	278	14	a	a	DET
admet-628	278	15	single	single	ADJ
admet-628	278	16	oral	oral	ADJ
admet-628	278	17	dose	dose	NOUN
admet-628	278	18	of	of	ADP
admet-628	278	19	30	30	NUM
admet-628	278	20	mg	mg	PROPN
admet-628	278	21	/	/	SYM
admet-628	278	22	g	g	NOUN
admet-628	278	23	op	op	NOUN
admet-628	278	24	,	,	PUNCT
admet-628	278	25	(	(	PUNCT
admet-628	278	26	b	b	X
admet-628	278	27	)	)	PUNCT
admet-628	278	28	an	an	DET
admet-628	278	29	i.v	i.v	PROPN
admet-628	278	30	.	.	PUNCT
admet-628	278	31	injection	injection	NOUN
admet-628	278	32	of	of	ADP
admet-628	278	33	30	30	NUM
admet-628	278	34	mg	mg	PROPN
admet-628	278	35	/	/	SYM
admet-628	278	36	kg	kg	PROPN
admet-628	278	37	oc	oc	PROPN
admet-628	278	38	.	.	PROPN
admet-628	278	39	data	datum	NOUN
admet-628	278	40	points	point	NOUN
admet-628	278	41	,	,	PUNCT
admet-628	278	42	means	mean	VERB
admet-628	278	43	+	+	X
admet-628	279	1	s.d	s.d	PROPN
admet-628	279	2	.	.	PROPN
admet-628	279	3	of	of	ADP
admet-628	279	4	the	the	DET
admet-628	279	5	experimental	experimental	ADJ
admet-628	279	6	plasma	plasma	NOUN
admet-628	279	7	/	/	SYM
admet-628	279	8	tissue	tissue	NOUN
admet-628	279	9	concentrations	concentration	NOUN
admet-628	279	10	.	.	PUNCT
admet-628	280	1	(	(	PUNCT
admet-628	280	2	—	—	PUNCT
admet-628	280	3	—	—	PUNCT
admet-628	280	4	)	)	PUNCT
admet-628	280	5	model	model	NOUN
admet-628	280	6	-	-	PUNCT
admet-628	280	7	simulated	simulate	VERB
admet-628	280	8	oc	oc	NOUN
admet-628	280	9	concentrations	concentration	NOUN
admet-628	280	10	.	.	PUNCT
admet-628	281	1	experimental	experimental	ADJ
admet-628	281	2	data	datum	NOUN
admet-628	281	3	were	be	AUX
admet-628	281	4	adapted	adapt	VERB
admet-628	281	5	from	from	ADP
admet-628	281	6	eisenberg	eisenberg	PROPN
admet-628	281	7	et	et	PROPN
admet-628	281	8	al	al	PROPN
admet-628	281	9	.	.	PUNCT
admet-628	282	1	[	[	X
admet-628	282	2	37	37	NUM
admet-628	282	3	]	]	PUNCT
admet-628	282	4	calibration	calibration	NOUN
admet-628	282	5	of	of	ADP
admet-628	282	6	the	the	DET
admet-628	282	7	human	human	ADJ
admet-628	282	8	pbpk	pbpk	PROPN
admet-628	282	9	model	model	NOUN
admet-628	282	10	the	the	DET
admet-628	282	11	human	human	ADJ
admet-628	282	12	pbpk	pbpk	PROPN
admet-628	282	13	model	model	NOUN
admet-628	282	14	was	be	AUX
admet-628	282	15	calibrated	calibrate	VERB
admet-628	282	16	using	use	VERB
admet-628	282	17	the	the	DET
admet-628	282	18	plasma	plasma	NOUN
admet-628	282	19	concentration	concentration	NOUN
admet-628	282	20	-	-	PUNCT
admet-628	282	21	time	time	NOUN
admet-628	282	22	data	datum	NOUN
admet-628	282	23	from	from	ADP
admet-628	282	24	humans	human	NOUN
admet-628	282	25	receiving	receive	VERB
admet-628	282	26	either	either	CCONJ
admet-628	282	27	a	a	DET
admet-628	282	28	single	single	ADJ
admet-628	282	29	oral	oral	ADJ
admet-628	282	30	dose	dose	NOUN
admet-628	282	31	of	of	ADP
admet-628	282	32	150	150	NUM
admet-628	282	33	mg	mg	NOUN
admet-628	282	34	op	op	NOUN
admet-628	282	35	or	or	CCONJ
admet-628	282	36	an	an	DET
admet-628	282	37	i.v	i.v	PROPN
admet-628	282	38	.	.	PUNCT
admet-628	283	1	infusion	infusion	NOUN
admet-628	283	2	of	of	ADP
admet-628	283	3	150	150	NUM
admet-628	283	4	mg	mg	NOUN
admet-628	283	5	oc	oc	ADP
admet-628	283	6	[	[	X
admet-628	283	7	14	14	NUM
admet-628	283	8	]	]	PUNCT
admet-628	283	9	.	.	PUNCT
admet-628	284	1	fig	fig	NOUN
admet-628	284	2	.	.	PUNCT
admet-628	285	1	6	6	NUM
admet-628	285	2	shows	show	VERB
admet-628	285	3	the	the	DET
admet-628	285	4	observed	observe	VERB
admet-628	285	5	concentrations	concentration	NOUN
admet-628	285	6	together	together	ADV
admet-628	285	7	with	with	ADP
admet-628	285	8	the	the	DET
admet-628	285	9	simulated	simulate	VERB
admet-628	285	10	concentrations	concentration	NOUN
admet-628	285	11	for	for	ADP
admet-628	285	12	humans	human	NOUN
admet-628	285	13	after	after	ADP
admet-628	285	14	p.o	p.o	PROPN
admet-628	285	15	.	.	PROPN
admet-628	285	16	administration	administration	PROPN
admet-628	285	17	of	of	ADP
admet-628	285	18	op	op	NOUN
admet-628	285	19	.	.	PUNCT
admet-628	286	1	fig	fig	NOUN
admet-628	286	2	.	.	PUNCT
admet-628	287	1	7	7	NUM
admet-628	287	2	shows	show	VERB
admet-628	287	3	the	the	DET
admet-628	287	4	model	model	NOUN
admet-628	287	5	simulation	simulation	NOUN
admet-628	287	6	and	and	CCONJ
admet-628	287	7	the	the	DET
admet-628	287	8	experimental	experimental	ADJ
admet-628	287	9	concentration	concentration	NOUN
admet-628	287	10	-	-	PUNCT
admet-628	287	11	time	time	NOUN
admet-628	287	12	profiles	profile	NOUN
admet-628	287	13	of	of	ADP
admet-628	287	14	plasma	plasma	NOUN
admet-628	287	15	oc	oc	NOUN
admet-628	287	16	in	in	ADP
admet-628	287	17	humans	human	NOUN
admet-628	287	18	during	during	ADP
admet-628	287	19	and	and	CCONJ
admet-628	287	20	after	after	ADP
admet-628	287	21	a	a	DET
admet-628	287	22	3	3	NUM
admet-628	287	23	-	-	PUNCT
admet-628	287	24	hour	hour	NOUN
admet-628	287	25	i.v	i.v	PROPN
admet-628	287	26	.	.	PUNCT
admet-628	287	27	infusion	infusion	NOUN
admet-628	287	28	of	of	ADP
admet-628	287	29	150	150	NUM
admet-628	287	30	mg	mg	NOUN
admet-628	287	31	oc	oc	PROPN
admet-628	287	32	.	.	PUNCT
admet-628	288	1	the	the	DET
admet-628	288	2	pbpk	pbpk	PROPN
admet-628	288	3	model	model	NOUN
admet-628	288	4	was	be	AUX
admet-628	288	5	able	able	ADJ
admet-628	288	6	to	to	PART
admet-628	288	7	describe	describe	VERB
admet-628	288	8	the	the	DET
admet-628	288	9	experimental	experimental	ADJ
admet-628	288	10	data	datum	NOUN
admet-628	288	11	for	for	ADP
admet-628	288	12	both	both	DET
admet-628	288	13	administration	administration	NOUN
admet-628	288	14	routes	route	NOUN
admet-628	288	15	reasonably	reasonably	ADV
admet-628	288	16	well	well	ADV
admet-628	288	17	.	.	PUNCT
admet-628	289	1	the	the	DET
admet-628	289	2	optimized	optimize	VERB
admet-628	289	3	f	f	PROPN
admet-628	289	4	value	value	NOUN
admet-628	289	5	for	for	ADP
admet-628	289	6	human	human	ADJ
admet-628	289	7	model	model	NOUN
admet-628	289	8	g.	g.	PROPN
admet-628	289	9	gao	gao	PROPN
admet-628	289	10	et	et	PROPN
admet-628	289	11	al	al	PROPN
admet-628	289	12	.	.	PROPN
admet-628	289	13	admet	admet	PROPN
admet-628	289	14	&	&	CCONJ
admet-628	289	15	dmpk	dmpk	PROPN
admet-628	289	16	7(1	7(1	PROPN
admet-628	289	17	)	)	PUNCT
admet-628	289	18	(	(	PUNCT
admet-628	289	19	2019	2019	NUM
admet-628	289	20	)	)	PUNCT
admet-628	289	21	22	22	NUM
admet-628	289	22	-	-	SYM
admet-628	289	23	43	43	NUM
admet-628	289	24	34	34	NUM
admet-628	289	25	was	be	AUX
admet-628	289	26	0.75	0.75	NUM
admet-628	289	27	(	(	PUNCT
admet-628	289	28	table	table	NOUN
admet-628	289	29	2	2	NUM
admet-628	289	30	)	)	PUNCT
admet-628	289	31	which	which	PRON
admet-628	289	32	showed	show	VERB
admet-628	289	33	extensive	extensive	ADJ
admet-628	289	34	absorption	absorption	NOUN
admet-628	289	35	of	of	ADP
admet-628	289	36	orally	orally	ADV
admet-628	289	37	administered	administer	VERB
admet-628	289	38	op	op	NOUN
admet-628	289	39	.	.	PUNCT
admet-628	290	1	simulated	simulate	VERB
admet-628	290	2	cmax	cmax	NOUN
admet-628	290	3	for	for	ADP
admet-628	290	4	op	op	NOUN
admet-628	290	5	and	and	CCONJ
admet-628	290	6	oc	oc	NOUN
admet-628	290	7	in	in	ADP
admet-628	290	8	the	the	DET
admet-628	290	9	plasma	plasma	NOUN
admet-628	290	10	was	be	AUX
admet-628	290	11	0.08	0.08	NUM
admet-628	290	12	and	and	CCONJ
admet-628	290	13	0.44	0.44	NUM
admet-628	290	14	µg	µg	NOUN
admet-628	290	15	/	/	SYM
admet-628	290	16	ml	ml	NOUN
admet-628	290	17	,	,	PUNCT
admet-628	290	18	respectively	respectively	ADV
admet-628	290	19	,	,	PUNCT
admet-628	290	20	after	after	ADP
admet-628	290	21	dosing	dose	VERB
admet-628	290	22	humans	human	NOUN
admet-628	290	23	with	with	ADP
admet-628	290	24	150	150	NUM
admet-628	290	25	mg	mg	NOUN
admet-628	290	26	op	op	NOUN
admet-628	290	27	orally	orally	ADV
admet-628	290	28	(	(	PUNCT
admet-628	290	29	fig.6	fig.6	PROPN
admet-628	290	30	)	)	PUNCT
admet-628	290	31	.	.	PUNCT
admet-628	291	1	the	the	DET
admet-628	291	2	time	time	NOUN
admet-628	291	3	to	to	PART
admet-628	291	4	reach	reach	VERB
admet-628	291	5	peak	peak	NOUN
admet-628	291	6	plasma	plasma	NOUN
admet-628	291	7	concentration	concentration	NOUN
admet-628	291	8	(	(	PUNCT
admet-628	291	9	tmax	tmax	ADV
admet-628	291	10	)	)	PUNCT
admet-628	291	11	for	for	ADP
admet-628	291	12	op	op	NOUN
admet-628	291	13	and	and	CCONJ
admet-628	291	14	oc	oc	NOUN
admet-628	291	15	was	be	AUX
admet-628	291	16	1	1	NUM
admet-628	291	17	and	and	CCONJ
admet-628	291	18	4	4	NUM
admet-628	291	19	h	h	NOUN
admet-628	291	20	,	,	PUNCT
admet-628	291	21	respectively	respectively	ADV
admet-628	291	22	.	.	PUNCT
admet-628	292	1	these	these	DET
admet-628	292	2	results	result	NOUN
admet-628	292	3	indicated	indicate	VERB
admet-628	292	4	that	that	SCONJ
admet-628	292	5	oc	oc	NOUN
admet-628	292	6	could	could	AUX
admet-628	292	7	remain	remain	VERB
admet-628	292	8	in	in	ADP
admet-628	292	9	the	the	DET
admet-628	292	10	plasma	plasma	NOUN
admet-628	292	11	for	for	ADP
admet-628	292	12	a	a	DET
admet-628	292	13	longer	long	ADJ
admet-628	292	14	period	period	NOUN
admet-628	292	15	than	than	ADP
admet-628	292	16	op	op	NOUN
admet-628	292	17	.	.	PUNCT
admet-628	293	1	following	follow	VERB
admet-628	293	2	oral	oral	ADJ
admet-628	293	3	administration	administration	NOUN
admet-628	293	4	of	of	ADP
admet-628	293	5	op	op	NOUN
admet-628	293	6	,	,	PUNCT
admet-628	293	7	plasma	plasma	NOUN
admet-628	293	8	oc	oc	ADP
admet-628	293	9	concentrations	concentration	NOUN
admet-628	293	10	in	in	ADP
admet-628	293	11	humans	human	NOUN
admet-628	293	12	were	be	AUX
admet-628	293	13	always	always	ADV
admet-628	293	14	>	>	X
admet-628	293	15	40	40	NUM
admet-628	293	16	ng	ng	NOUN
admet-628	293	17	/	/	SYM
admet-628	293	18	ml	ml	NOUN
admet-628	293	19	after	after	ADP
admet-628	293	20	the	the	DET
admet-628	293	21	initial	initial	ADJ
admet-628	293	22	absorption	absorption	NOUN
admet-628	293	23	phase	phase	NOUN
admet-628	293	24	(	(	PUNCT
admet-628	293	25	fig	fig	NOUN
admet-628	293	26	.	.	PUNCT
admet-628	293	27	6	6	NUM
admet-628	293	28	)	)	PUNCT
admet-628	293	29	,	,	PUNCT
admet-628	293	30	which	which	PRON
admet-628	293	31	was	be	AUX
admet-628	293	32	much	much	ADV
admet-628	293	33	higher	high	ADJ
admet-628	293	34	than	than	ADP
admet-628	293	35	the	the	DET
admet-628	293	36	minimum	minimum	ADJ
admet-628	293	37	ic50	ic50	PROPN
admet-628	293	38	of	of	ADP
admet-628	293	39	neuraminidase	neuraminidase	NOUN
admet-628	293	40	inhibition	inhibition	NOUN
admet-628	293	41	levels	level	NOUN
admet-628	293	42	(	(	PUNCT
admet-628	293	43	3	3	NUM
admet-628	293	44	-	-	SYM
admet-628	293	45	10	10	NUM
admet-628	293	46	ng	ng	PROPN
admet-628	293	47	/	/	SYM
admet-628	293	48	ml	ml	VERB
admet-628	293	49	)	)	PUNCT
admet-628	293	50	reported	report	VERB
admet-628	293	51	previously	previously	ADV
admet-628	293	52	by	by	ADP
admet-628	293	53	davies	davy	NOUN
admet-628	293	54	[	[	X
admet-628	293	55	26	26	NUM
admet-628	293	56	]	]	PUNCT
admet-628	293	57	.	.	PUNCT
admet-628	294	1	figure	figure	NOUN
admet-628	294	2	6	6	NUM
admet-628	294	3	.	.	PUNCT
admet-628	294	4	typical	typical	ADJ
admet-628	294	5	op	op	NOUN
admet-628	294	6	and	and	CCONJ
admet-628	294	7	oc	oc	ADP
admet-628	294	8	concentration	concentration	NOUN
admet-628	294	9	-	-	PUNCT
admet-628	294	10	time	time	NOUN
admet-628	294	11	profiles	profile	NOUN
admet-628	294	12	in	in	ADP
admet-628	294	13	the	the	DET
admet-628	294	14	plasma	plasma	NOUN
admet-628	294	15	of	of	ADP
admet-628	294	16	human	human	ADJ
admet-628	294	17	volunteers	volunteer	NOUN
admet-628	294	18	receiving	receive	VERB
admet-628	294	19	an	an	DET
admet-628	294	20	oral	oral	ADJ
admet-628	294	21	dose	dose	NOUN
admet-628	294	22	of	of	ADP
admet-628	294	23	150	150	NUM
admet-628	294	24	mg	mg	NUM
admet-628	294	25	op	op	NOUN
admet-628	294	26	.	.	PUNCT
admet-628	295	1	data	datum	NOUN
admet-628	295	2	points	point	NOUN
admet-628	295	3	represent	represent	VERB
admet-628	295	4	means	mean	NOUN
admet-628	295	5	+	+	X
admet-628	295	6	s.d	s.d	PROPN
admet-628	295	7	.	.	PROPN
admet-628	295	8	of	of	ADP
admet-628	295	9	the	the	DET
admet-628	295	10	experimental	experimental	ADJ
admet-628	295	11	data	datum	NOUN
admet-628	295	12	which	which	PRON
admet-628	295	13	are	be	AUX
admet-628	295	14	adapted	adapt	VERB
admet-628	295	15	from	from	ADP
admet-628	295	16	he	he	PRON
admet-628	295	17	et	et	PROPN
admet-628	295	18	al	al	PROPN
admet-628	295	19	.	.	PROPN
admet-628	295	20	,	,	PUNCT
admet-628	296	1	[	[	X
admet-628	296	2	14	14	NUM
admet-628	296	3	]	]	PUNCT
admet-628	296	4	.	.	PUNCT
admet-628	297	1	(	(	PUNCT
admet-628	297	2	_	_	PUNCT
admet-628	298	1	_	_	PUNCT
admet-628	298	2	_	_	PUNCT
admet-628	298	3	)	)	PUNCT
admet-628	298	4	model	model	NOUN
admet-628	298	5	-	-	PUNCT
admet-628	298	6	simulated	simulate	VERB
admet-628	298	7	op	op	NOUN
admet-628	298	8	concentrations	concentration	NOUN
admet-628	298	9	;	;	PUNCT
admet-628	298	10	(	(	PUNCT
admet-628	298	11	—	—	PUNCT
admet-628	298	12	—	—	PUNCT
admet-628	298	13	)	)	PUNCT
admet-628	298	14	model	model	NOUN
admet-628	298	15	-	-	PUNCT
admet-628	298	16	simulated	simulate	VERB
admet-628	298	17	oc	oc	ADP
admet-628	298	18	concentrations	concentration	NOUN
admet-628	298	19	figure	figure	VERB
admet-628	298	20	7	7	NUM
admet-628	298	21	.	.	PUNCT
admet-628	299	1	a	a	DET
admet-628	299	2	typical	typical	ADJ
admet-628	299	3	oc	oc	ADP
admet-628	299	4	concentration	concentration	NOUN
admet-628	299	5	-	-	PUNCT
admet-628	299	6	time	time	NOUN
admet-628	299	7	profile	profile	NOUN
admet-628	299	8	in	in	ADP
admet-628	299	9	the	the	DET
admet-628	299	10	plasma	plasma	NOUN
admet-628	299	11	of	of	ADP
admet-628	299	12	human	human	ADJ
admet-628	299	13	volunteers	volunteer	NOUN
admet-628	299	14	receiving	receive	VERB
admet-628	299	15	an	an	DET
admet-628	299	16	i.v	i.v	PROPN
admet-628	300	1	.	.	PUNCT
admet-628	300	2	infusion	infusion	NOUN
admet-628	300	3	of	of	ADP
admet-628	300	4	150	150	NUM
admet-628	300	5	mg	mg	PROPN
admet-628	300	6	oc	oc	PROPN
admet-628	300	7	.	.	PROPN
admet-628	300	8	data	datum	NOUN
admet-628	300	9	points	point	NOUN
admet-628	300	10	represent	represent	VERB
admet-628	300	11	means	mean	NOUN
admet-628	300	12	+	+	X
admet-628	301	1	s.d	s.d	PROPN
admet-628	302	1	.	.	PROPN
admet-628	302	2	of	of	ADP
admet-628	302	3	the	the	DET
admet-628	302	4	experimental	experimental	ADJ
admet-628	302	5	data	datum	NOUN
admet-628	302	6	which	which	PRON
admet-628	302	7	are	be	AUX
admet-628	302	8	adapted	adapt	VERB
admet-628	302	9	from	from	ADP
admet-628	302	10	he	he	PRON
admet-628	302	11	et	et	PROPN
admet-628	302	12	al	al	PROPN
admet-628	302	13	.	.	PROPN
admet-628	302	14	,	,	PUNCT
admet-628	303	1	[	[	X
admet-628	303	2	14	14	NUM
admet-628	303	3	]	]	PUNCT
admet-628	303	4	.	.	PUNCT
admet-628	304	1	(	(	PUNCT
admet-628	304	2	—	—	PUNCT
admet-628	304	3	—	—	PUNCT
admet-628	304	4	)	)	PUNCT
admet-628	304	5	modelsimulated	modelsimulate	VERB
admet-628	304	6	oc	oc	ADP
admet-628	304	7	concentrations	concentration	NOUN
admet-628	304	8	prediction	prediction	NOUN
admet-628	304	9	of	of	ADP
admet-628	304	10	tissue	tissue	NOUN
admet-628	304	11	/	/	SYM
admet-628	304	12	plasma	plasma	NOUN
admet-628	304	13	op	op	NOUN
admet-628	304	14	/	/	SYM
admet-628	304	15	oc	oc	NOUN
admet-628	304	16	concentrations	concentration	NOUN
admet-628	304	17	in	in	ADP
admet-628	304	18	humans	human	NOUN
admet-628	304	19	receiving	receive	VERB
admet-628	304	20	multiple	multiple	ADJ
admet-628	304	21	op	op	NOUN
admet-628	304	22	dose	dose	NOUN
admet-628	304	23	regimens	regimen	NOUN
admet-628	304	24	the	the	DET
admet-628	304	25	pbpk	pbpk	PROPN
admet-628	304	26	model	model	NOUN
admet-628	304	27	was	be	AUX
admet-628	304	28	used	use	VERB
admet-628	304	29	to	to	PART
admet-628	304	30	simulate	simulate	VERB
admet-628	304	31	the	the	DET
admet-628	304	32	kinetics	kinetic	NOUN
admet-628	304	33	of	of	ADP
admet-628	304	34	plasma	plasma	NOUN
admet-628	304	35	oc	oc	NOUN
admet-628	304	36	in	in	ADP
admet-628	304	37	humans	human	NOUN
admet-628	304	38	after	after	ADP
admet-628	304	39	receiving	receive	VERB
admet-628	304	40	multiple	multiple	ADJ
admet-628	304	41	oral	oral	ADJ
admet-628	304	42	dose	dose	NOUN
admet-628	304	43	regimens	regimen	NOUN
admet-628	304	44	of	of	ADP
admet-628	304	45	op	op	NOUN
admet-628	305	1	[	[	X
admet-628	305	2	14	14	NUM
admet-628	305	3	]	]	PUNCT
admet-628	305	4	.	.	PUNCT
admet-628	306	1	in	in	ADP
admet-628	306	2	their	their	PRON
admet-628	306	3	studies	study	NOUN
admet-628	306	4	,	,	PUNCT
admet-628	306	5	the	the	DET
admet-628	306	6	human	human	ADJ
admet-628	306	7	volunteers	volunteer	NOUN
admet-628	306	8	were	be	AUX
admet-628	306	9	dosed	dose	VERB
admet-628	306	10	with	with	ADP
admet-628	306	11	50	50	NUM
admet-628	306	12	,	,	PUNCT
admet-628	306	13	100	100	NUM
admet-628	306	14	,	,	PUNCT
admet-628	306	15	200	200	NUM
admet-628	306	16	and	and	CCONJ
admet-628	306	17	500	500	NUM
admet-628	306	18	mg	mg	NOUN
admet-628	306	19	op	op	NOUN
admet-628	306	20	b.i.d	b.i.d	PROPN
admet-628	306	21	.	.	PUNCT
admet-628	307	1	for	for	ADP
admet-628	307	2	6	6	NUM
admet-628	307	3	days	day	NOUN
admet-628	307	4	.	.	PUNCT
admet-628	308	1	the	the	DET
admet-628	308	2	model	model	NOUN
admet-628	308	3	-	-	PUNCT
admet-628	308	4	predicted	predict	VERB
admet-628	308	5	cmax	cmax	NOUN
admet-628	308	6	/	/	SYM
admet-628	308	7	cmin	cmin	NOUN
admet-628	308	8	ratios	ratio	NOUN
admet-628	308	9	for	for	ADP
admet-628	308	10	oc	oc	NOUN
admet-628	308	11	in	in	ADP
admet-628	308	12	the	the	DET
admet-628	308	13	plasma	plasma	NOUN
admet-628	308	14	were	be	AUX
admet-628	308	15	3.5	3.5	NUM
admet-628	308	16	(	(	PUNCT
admet-628	308	17	218	218	NUM
admet-628	308	18	ng	ng	NOUN
admet-628	308	19	/	/	SYM
admet-628	308	20	ml	ml	PROPN
admet-628	308	21	:	:	PUNCT
admet-628	308	22	62	62	NUM
admet-628	308	23	ng	ng	NOUN
admet-628	308	24	/	/	SYM
admet-628	308	25	ml	ml	PROPN
admet-628	308	26	)	)	PUNCT
admet-628	308	27	,	,	PUNCT
admet-628	308	28	2.5	2.5	NUM
admet-628	308	29	(	(	PUNCT
admet-628	308	30	400	400	NUM
admet-628	308	31	ng	ng	NOUN
admet-628	308	32	/	/	SYM
admet-628	308	33	ml	ml	PROPN
admet-628	308	34	:	:	PUNCT
admet-628	308	35	158	158	NUM
admet-628	308	36	ng	ng	NOUN
admet-628	308	37	/	/	SYM
admet-628	308	38	ml	ml	PROPN
admet-628	308	39	)	)	PUNCT
admet-628	308	40	,	,	PUNCT
admet-628	308	41	3.0	3.0	NUM
admet-628	308	42	(	(	PUNCT
admet-628	308	43	838	838	NUM
admet-628	308	44	ng	ng	NOUN
admet-628	308	45	/	/	SYM
admet-628	308	46	ml	ml	PROPN
admet-628	308	47	:	:	PUNCT
admet-628	308	48	279	279	NUM
admet-628	308	49	ng	ng	NOUN
admet-628	308	50	/	/	SYM
admet-628	308	51	ml	ml	PROPN
admet-628	308	52	)	)	PUNCT
admet-628	308	53	and	and	CCONJ
admet-628	308	54	1.9	1.9	NUM
admet-628	308	55	(	(	PUNCT
admet-628	308	56	1846	1846	NUM
admet-628	308	57	ng	ng	NOUN
admet-628	308	58	/	/	SYM
admet-628	308	59	ml	ml	PROPN
admet-628	308	60	:	:	PUNCT
admet-628	308	61	959	959	NUM
admet-628	308	62	ng	ng	NOUN
admet-628	308	63	/	/	SYM
admet-628	308	64	ml	ml	NOUN
admet-628	308	65	)	)	PUNCT
admet-628	308	66	,	,	PUNCT
admet-628	308	67	respectively	respectively	ADV
admet-628	308	68	(	(	PUNCT
admet-628	308	69	fig	fig	NOUN
admet-628	308	70	.	.	PUNCT
admet-628	309	1	8)	8)	NUM
admet-628	309	2	.	.	PUNCT
admet-628	310	1	the	the	DET
admet-628	310	2	cmax	cmax	NOUN
admet-628	310	3	/	/	SYM
admet-628	310	4	cmin	cmin	NOUN
admet-628	310	5	ratio	ratio	NOUN
admet-628	310	6	decreases	decrease	VERB
admet-628	310	7	with	with	ADP
admet-628	310	8	an	an	DET
admet-628	310	9	increasing	increase	VERB
admet-628	310	10	external	external	ADJ
admet-628	310	11	op	op	NOUN
admet-628	310	12	dose	dose	VERB
admet-628	310	13	except	except	SCONJ
admet-628	310	14	for	for	ADP
admet-628	310	15	the	the	DET
admet-628	310	16	100	100	NUM
admet-628	310	17	mg	mg	PROPN
admet-628	310	18	b.i.d	b.i.d	PROPN
admet-628	310	19	dose	dose	PROPN
admet-628	310	20	,	,	PUNCT
admet-628	310	21	which	which	PRON
admet-628	310	22	indicates	indicate	VERB
admet-628	310	23	less	less	ADJ
admet-628	310	24	oc	oc	ADP
admet-628	310	25	concentration	concentration	NOUN
admet-628	310	26	fluctuation	fluctuation	NOUN
admet-628	310	27	in	in	ADP
admet-628	310	28	the	the	DET
admet-628	310	29	plasma	plasma	NOUN
admet-628	310	30	at	at	ADP
admet-628	310	31	a	a	DET
admet-628	310	32	higher	high	ADJ
admet-628	310	33	op	op	NOUN
admet-628	310	34	dose	dose	NOUN
admet-628	310	35	.	.	PUNCT
admet-628	311	1	in	in	ADP
admet-628	311	2	addition	addition	NOUN
admet-628	311	3	,	,	PUNCT
admet-628	311	4	the	the	DET
admet-628	311	5	pbpk	pbpk	ADJ
admet-628	311	6	model	model	NOUN
admet-628	311	7	was	be	AUX
admet-628	311	8	used	use	VERB
admet-628	311	9	to	to	PART
admet-628	311	10	predict	predict	VERB
admet-628	311	11	the	the	DET
admet-628	311	12	internal	internal	ADJ
admet-628	311	13	tissue	tissue	NOUN
admet-628	311	14	dose	dose	NOUN
admet-628	311	15	of	of	ADP
admet-628	311	16	oc	oc	NOUN
admet-628	311	17	in	in	ADP
admet-628	311	18	the	the	DET
admet-628	311	19	brain	brain	NOUN
admet-628	311	20	and	and	CCONJ
admet-628	311	21	the	the	DET
admet-628	311	22	lung	lung	NOUN
admet-628	311	23	of	of	ADP
admet-628	311	24	these	these	DET
admet-628	311	25	studies	study	NOUN
admet-628	311	26	.	.	PUNCT
admet-628	312	1	the	the	DET
admet-628	312	2	steady	steady	ADJ
admet-628	312	3	-	-	PUNCT
admet-628	312	4	state	state	NOUN
admet-628	312	5	oc	oc	NOUN
admet-628	312	6	doses	dose	NOUN
admet-628	312	7	/	/	SYM
admet-628	312	8	concentrations	concentration	NOUN
admet-628	312	9	predicted	predict	VERB
admet-628	312	10	for	for	ADP
admet-628	312	11	the	the	DET
admet-628	312	12	lungs	lung	NOUN
admet-628	312	13	and	and	CCONJ
admet-628	312	14	brain	brain	NOUN
admet-628	312	15	were	be	AUX
admet-628	312	16	found	find	VERB
admet-628	312	17	to	to	PART
admet-628	312	18	be	be	AUX
admet-628	312	19	lower	low	ADJ
admet-628	312	20	than	than	ADP
admet-628	312	21	that	that	PRON
admet-628	312	22	of	of	ADP
admet-628	312	23	the	the	DET
admet-628	312	24	plasma	plasma	NOUN
admet-628	312	25	.	.	PUNCT
admet-628	313	1	when	when	SCONJ
admet-628	313	2	the	the	DET
admet-628	313	3	dose	dose	NOUN
admet-628	313	4	metrics	metric	NOUN
admet-628	313	5	of	of	ADP
admet-628	313	6	oc	oc	NOUN
admet-628	313	7	were	be	AUX
admet-628	313	8	expressed	express	VERB
admet-628	313	9	in	in	ADP
admet-628	313	10	auc0	auc0	PROPN
admet-628	313	11	-	-	PUNCT
admet-628	313	12	6day	6day	PROPN
admet-628	313	13	,	,	PUNCT
admet-628	313	14	they	they	PRON
admet-628	313	15	were	be	AUX
admet-628	313	16	21.4	21.4	NUM
admet-628	313	17	,	,	PUNCT
admet-628	313	18	42.5	42.5	NUM
admet-628	313	19	,	,	PUNCT
admet-628	313	20	85.3	85.3	NUM
admet-628	313	21	and	and	CCONJ
admet-628	313	22	210.2	210.2	NUM
admet-628	313	23	µg	µg	ADJ
admet-628	313	24	/	/	SYM
admet-628	313	25	ml·h	ml·h	NUM
admet-628	313	26	,	,	PUNCT
admet-628	313	27	respectively	respectively	ADV
admet-628	313	28	,	,	PUNCT
admet-628	313	29	for	for	ADP
admet-628	313	30	the	the	DET
admet-628	313	31	50	50	NUM
admet-628	313	32	,	,	PUNCT
admet-628	313	33	100	100	NUM
admet-628	313	34	,	,	PUNCT
admet-628	313	35	200	200	NUM
admet-628	313	36	,	,	PUNCT
admet-628	313	37	and	and	CCONJ
admet-628	313	38	500	500	NUM
admet-628	313	39	mg	mg	PROPN
admet-628	313	40	doses	dose	NOUN
admet-628	313	41	.	.	PUNCT
admet-628	314	1	the	the	DET
admet-628	314	2	corresponding	correspond	VERB
admet-628	314	3	oc	oc	X
admet-628	314	4	dose	dose	NOUN
admet-628	314	5	metrics	metric	NOUN
admet-628	314	6	for	for	ADP
admet-628	314	7	the	the	DET
admet-628	314	8	lungs	lung	NOUN
admet-628	314	9	were	be	AUX
admet-628	314	10	10.7	10.7	NUM
admet-628	314	11	,	,	PUNCT
admet-628	314	12	21.2	21.2	NUM
admet-628	314	13	,	,	PUNCT
admet-628	314	14	42.6	42.6	NUM
admet-628	314	15	,	,	PUNCT
admet-628	314	16	105.0	105.0	NUM
admet-628	314	17	µg	µg	ADV
admet-628	314	18	/	/	SYM
admet-628	314	19	ml·h	ml·h	NUM
admet-628	314	20	,	,	PUNCT
admet-628	314	21	respectively	respectively	ADV
admet-628	314	22	.	.	PUNCT
admet-628	315	1	for	for	ADP
admet-628	315	2	the	the	DET
admet-628	315	3	brain	brain	NOUN
admet-628	315	4	,	,	PUNCT
admet-628	315	5	they	they	PRON
admet-628	315	6	were	be	AUX
admet-628	315	7	5.3	5.3	NUM
admet-628	315	8	,	,	PUNCT
admet-628	315	9	10.6	10.6	NUM
admet-628	315	10	,	,	PUNCT
admet-628	315	11	21.3	21.3	NUM
admet-628	315	12	,	,	PUNCT
admet-628	315	13	52.5	52.5	NUM
admet-628	315	14	µg	µg	NOUN
admet-628	315	15	/	/	SYM
admet-628	315	16	ml·h	ml·h	NUM
admet-628	315	17	,	,	PUNCT
admet-628	315	18	respectively	respectively	ADV
admet-628	315	19	.	.	PUNCT
admet-628	316	1	thus	thus	ADV
admet-628	316	2	,	,	PUNCT
admet-628	316	3	the	the	DET
admet-628	316	4	dose	dose	NOUN
admet-628	316	5	metrics	metric	NOUN
admet-628	316	6	of	of	ADP
admet-628	316	7	oc	oc	NOUN
admet-628	316	8	in	in	ADP
admet-628	316	9	these	these	DET
admet-628	316	10	organs	organ	NOUN
admet-628	316	11	/	/	SYM
admet-628	316	12	tissues	tissue	NOUN
admet-628	316	13	generally	generally	ADV
admet-628	316	14	decrease	decrease	VERB
admet-628	316	15	in	in	ADP
admet-628	316	16	the	the	DET
admet-628	316	17	order	order	NOUN
admet-628	316	18	of	of	ADP
admet-628	316	19	plasma	plasma	NOUN
admet-628	316	20	>	>	X
admet-628	316	21	lung	lung	PROPN
admet-628	316	22	>	>	X
admet-628	316	23	brain	brain	NOUN
admet-628	316	24	although	although	SCONJ
admet-628	316	25	they	they	PRON
admet-628	316	26	were	be	AUX
admet-628	316	27	all	all	ADV
admet-628	316	28	linearly	linearly	ADV
admet-628	316	29	related	relate	VERB
admet-628	316	30	to	to	ADP
admet-628	316	31	the	the	DET
admet-628	316	32	externally	externally	ADV
admet-628	316	33	applied	apply	VERB
admet-628	316	34	op	op	NOUN
admet-628	316	35	dose	dose	PROPN
admet-628	316	36	.	.	PUNCT
admet-628	317	1	admet	admet	PROPN
admet-628	317	2	&	&	CCONJ
admet-628	317	3	dmpk	dmpk	PROPN
admet-628	317	4	7(1	7(1	PROPN
admet-628	317	5	)	)	PUNCT
admet-628	317	6	(	(	PUNCT
admet-628	317	7	2019	2019	NUM
admet-628	317	8	)	)	PUNCT
admet-628	317	9	22	22	NUM
admet-628	317	10	-	-	SYM
admet-628	317	11	43	43	NUM
admet-628	317	12	a	a	DET
admet-628	317	13	physiologically	physiologically	ADV
admet-628	317	14	-	-	PUNCT
admet-628	317	15	based	base	VERB
admet-628	317	16	pharmacokinetic	pharmacokinetic	ADJ
admet-628	317	17	model	model	NOUN
admet-628	317	18	for	for	ADP
admet-628	317	19	oseltamivir	oseltamivir	PROPN
admet-628	317	20	doi	doi	PROPN
admet-628	317	21	:	:	PUNCT
admet-628	317	22	10.5599	10.5599	NUM
admet-628	317	23	/	/	SYM
admet-628	317	24	admet.628	admet.628	PROPN
admet-628	317	25	35	35	NUM
admet-628	317	26	figure	figure	NOUN
admet-628	317	27	8	8	NUM
admet-628	317	28	.	.	PUNCT
admet-628	318	1	plasma	plasma	NOUN
admet-628	318	2	oc	oc	ADP
admet-628	318	3	concentration	concentration	NOUN
admet-628	318	4	-	-	PUNCT
admet-628	318	5	time	time	NOUN
admet-628	318	6	profiles	profile	NOUN
admet-628	318	7	in	in	ADP
admet-628	318	8	human	human	ADJ
admet-628	318	9	volunteers	volunteer	NOUN
admet-628	318	10	receiving	receive	VERB
admet-628	318	11	multiple	multiple	ADJ
admet-628	318	12	oral	oral	ADJ
admet-628	318	13	dose	dose	NOUN
admet-628	318	14	regimens	regimen	NOUN
admet-628	318	15	of	of	ADP
admet-628	318	16	50	50	NUM
admet-628	318	17	,	,	PUNCT
admet-628	318	18	100	100	NUM
admet-628	318	19	,	,	PUNCT
admet-628	318	20	200	200	NUM
admet-628	318	21	or	or	CCONJ
admet-628	318	22	500	500	NUM
admet-628	318	23	mg	mg	NOUN
admet-628	318	24	op	op	NOUN
admet-628	318	25	b.i.d	b.i.d	PROPN
admet-628	318	26	.	.	PUNCT
admet-628	319	1	for	for	ADP
admet-628	319	2	6	6	NUM
admet-628	319	3	days	day	NOUN
admet-628	319	4	.	.	PUNCT
admet-628	320	1	data	datum	NOUN
admet-628	320	2	points	point	NOUN
admet-628	320	3	represent	represent	VERB
admet-628	320	4	means	mean	NOUN
admet-628	320	5	+	+	X
admet-628	320	6	s.d	s.d	PROPN
admet-628	320	7	.	.	PROPN
admet-628	320	8	of	of	ADP
admet-628	320	9	the	the	DET
admet-628	320	10	experimental	experimental	ADJ
admet-628	320	11	plasma	plasma	NOUN
admet-628	320	12	oc	oc	ADP
admet-628	320	13	concentrations	concentration	NOUN
admet-628	320	14	which	which	PRON
admet-628	320	15	are	be	AUX
admet-628	320	16	adapted	adapt	VERB
admet-628	320	17	from	from	ADP
admet-628	320	18	he	he	PRON
admet-628	320	19	et	et	PROPN
admet-628	320	20	al	al	PROPN
admet-628	320	21	,	,	PUNCT
admet-628	320	22	(	(	PUNCT
admet-628	320	23	17	17	NUM
admet-628	320	24	)	)	PUNCT
admet-628	320	25	.	.	PUNCT
admet-628	321	1	(	(	PUNCT
admet-628	321	2	_	_	PUNCT
admet-628	322	1	_	_	PUNCT
admet-628	322	2	_	_	PUNCT
admet-628	322	3	)	)	PUNCT
admet-628	322	4	model	model	NOUN
admet-628	322	5	-	-	PUNCT
admet-628	322	6	simulated	simulate	VERB
admet-628	322	7	oc	oc	NOUN
admet-628	322	8	concentrations	concentration	NOUN
admet-628	322	9	we	we	PRON
admet-628	322	10	have	have	AUX
admet-628	322	11	also	also	ADV
admet-628	322	12	used	use	VERB
admet-628	322	13	the	the	DET
admet-628	322	14	human	human	ADJ
admet-628	322	15	pbpk	pbpk	PROPN
admet-628	322	16	model	model	NOUN
admet-628	322	17	to	to	PART
admet-628	322	18	simulate	simulate	VERB
admet-628	322	19	oc	oc	ADP
admet-628	322	20	(	(	PUNCT
admet-628	322	21	fig	fig	NOUN
admet-628	322	22	.	.	PUNCT
admet-628	323	1	9	9	NUM
admet-628	323	2	)	)	PUNCT
admet-628	324	1	and	and	CCONJ
admet-628	324	2	op	op	NOUN
admet-628	324	3	(	(	PUNCT
admet-628	324	4	fig	fig	NOUN
admet-628	324	5	.	.	PUNCT
admet-628	324	6	10	10	NUM
admet-628	324	7	)	)	PUNCT
admet-628	324	8	dose	dose	NOUN
admet-628	324	9	metrics	metric	NOUN
admet-628	324	10	in	in	ADP
admet-628	324	11	a	a	DET
admet-628	324	12	hypothetical	hypothetical	ADJ
admet-628	324	13	human	human	NOUN
admet-628	324	14	after	after	ADP
admet-628	324	15	receiving	receive	VERB
admet-628	324	16	the	the	DET
admet-628	324	17	recommended	recommend	VERB
admet-628	324	18	dose	dose	NOUN
admet-628	324	19	regimen	regiman	NOUN
admet-628	324	20	of	of	ADP
admet-628	324	21	75	75	NUM
admet-628	324	22	mg	mg	NOUN
admet-628	324	23	op	op	NOUN
admet-628	324	24	b.i.d	b.i.d	PROPN
admet-628	324	25	.	.	PUNCT
admet-628	325	1	for	for	ADP
admet-628	325	2	6	6	NUM
admet-628	325	3	days	day	NOUN
admet-628	325	4	.	.	PUNCT
admet-628	326	1	fig	fig	NOUN
admet-628	326	2	.	.	PUNCT
admet-628	327	1	9	9	NUM
admet-628	327	2	shows	show	VERB
admet-628	327	3	the	the	DET
admet-628	327	4	simulated	simulate	VERB
admet-628	327	5	oc	oc	ADP
admet-628	327	6	concentrations	concentration	NOUN
admet-628	327	7	in	in	ADP
admet-628	327	8	the	the	DET
admet-628	327	9	plasma	plasma	NOUN
admet-628	327	10	and	and	CCONJ
admet-628	327	11	major	major	ADJ
admet-628	327	12	organs	organ	NOUN
admet-628	327	13	,	,	PUNCT
admet-628	327	14	which	which	PRON
admet-628	327	15	decreases	decrease	VERB
admet-628	327	16	in	in	ADP
admet-628	327	17	the	the	DET
admet-628	327	18	order	order	NOUN
admet-628	327	19	of	of	ADP
admet-628	327	20	liver	liver	NOUN
admet-628	327	21	>	>	X
admet-628	327	22	kidney	kidney	NOUN
admet-628	327	23	>	>	X
admet-628	327	24	plasma	plasma	NOUN
admet-628	328	1	≈	≈	PROPN
admet-628	328	2	the	the	DET
admet-628	328	3	rest	rest	NOUN
admet-628	328	4	of	of	ADP
admet-628	328	5	body	body	NOUN
admet-628	328	6	>	>	X
admet-628	328	7	lung	lung	PROPN
admet-628	328	8	>	>	X
admet-628	328	9	brain	brain	NOUN
admet-628	329	1	≈	≈	PROPN
admet-628	329	2	fat	fat	NOUN
admet-628	329	3	.	.	PUNCT
admet-628	330	1	the	the	DET
admet-628	330	2	mean	mean	ADJ
admet-628	330	3	oc	oc	ADP
admet-628	330	4	concentrations	concentration	NOUN
admet-628	330	5	predicted	predict	VERB
admet-628	330	6	for	for	ADP
admet-628	330	7	the	the	DET
admet-628	330	8	lung	lung	NOUN
admet-628	330	9	and	and	CCONJ
admet-628	330	10	brain	brain	NOUN
admet-628	330	11	were	be	AUX
admet-628	330	12	≥0.052	≥0.052	PRON
admet-628	330	13	µg	µg	ADJ
admet-628	330	14	/	/	SYM
admet-628	330	15	g	g	PROPN
admet-628	330	16	and	and	CCONJ
admet-628	330	17	≥	≥	NOUN
admet-628	330	18	0.026µg	0.026µg	NOUN
admet-628	330	19	/	/	SYM
admet-628	330	20	g	g	NOUN
admet-628	330	21	,	,	PUNCT
admet-628	330	22	respectively	respectively	ADV
admet-628	330	23	.	.	PUNCT
admet-628	331	1	fig	fig	NOUN
admet-628	331	2	10	10	NUM
admet-628	331	3	shows	show	VERB
admet-628	331	4	the	the	DET
admet-628	331	5	simulated	simulated	ADJ
admet-628	331	6	op	op	NOUN
admet-628	331	7	concentrations	concentration	NOUN
admet-628	331	8	in	in	ADP
admet-628	331	9	the	the	DET
admet-628	331	10	human	human	ADJ
admet-628	331	11	plasma	plasma	NOUN
admet-628	331	12	/	/	SYM
admet-628	331	13	organs	organ	NOUN
admet-628	331	14	which	which	PRON
admet-628	331	15	decreased	decrease	VERB
admet-628	331	16	in	in	ADP
admet-628	331	17	the	the	DET
admet-628	331	18	order	order	NOUN
admet-628	331	19	of	of	ADP
admet-628	331	20	liver	liver	NOUN
admet-628	331	21	>	>	X
admet-628	331	22	lung	lung	PROPN
admet-628	331	23	>	>	X
admet-628	331	24	kidney	kidney	PROPN
admet-628	331	25	>	>	X
admet-628	331	26	the	the	DET
admet-628	331	27	rest	rest	NOUN
admet-628	331	28	of	of	ADP
admet-628	331	29	body	body	NOUN
admet-628	331	30	>	>	X
admet-628	331	31	muscle	muscle	NOUN
admet-628	331	32	≈	≈	PROPN
admet-628	331	33	spleen	spleen	PROPN
admet-628	331	34	>	>	X
admet-628	331	35	plasma	plasma	NOUN
admet-628	331	36	>	>	X
admet-628	331	37	brain	brain	NOUN
admet-628	332	1	≈	≈	PROPN
admet-628	332	2	fat	fat	NOUN
admet-628	332	3	.	.	PUNCT
admet-628	333	1	the	the	DET
admet-628	333	2	predicted	predict	VERB
admet-628	333	3	mean	mean	VERB
admet-628	333	4	op	op	NOUN
admet-628	333	5	concentrations	concentration	NOUN
admet-628	333	6	in	in	ADP
admet-628	333	7	the	the	DET
admet-628	333	8	gut	gut	NOUN
admet-628	333	9	was	be	AUX
admet-628	333	10	high	high	ADJ
admet-628	333	11	(	(	PUNCT
admet-628	333	12	3.72	3.72	NUM
admet-628	333	13	µg	µg	NOUN
admet-628	333	14	/	/	SYM
admet-628	333	15	g	g	NOUN
admet-628	333	16	)	)	PUNCT
admet-628	333	17	indicating	indicate	VERB
admet-628	333	18	a	a	DET
admet-628	333	19	significant	significant	ADJ
admet-628	333	20	amount	amount	NOUN
admet-628	333	21	of	of	ADP
admet-628	333	22	op	op	NOUN
admet-628	333	23	was	be	AUX
admet-628	333	24	not	not	PART
admet-628	333	25	absorbed	absorb	VERB
admet-628	333	26	.	.	PUNCT
admet-628	334	1	figure	figure	NOUN
admet-628	334	2	9	9	NUM
admet-628	334	3	.	.	PUNCT
admet-628	334	4	simulated	simulate	VERB
admet-628	334	5	oc	oc	ADP
admet-628	334	6	concentration	concentration	NOUN
admet-628	334	7	-	-	PUNCT
admet-628	334	8	time	time	NOUN
admet-628	334	9	profiles	profile	NOUN
admet-628	334	10	in	in	ADP
admet-628	334	11	the	the	DET
admet-628	334	12	plasma	plasma	NOUN
admet-628	334	13	and	and	CCONJ
admet-628	334	14	tissues	tissue	NOUN
admet-628	334	15	of	of	ADP
admet-628	334	16	a	a	DET
admet-628	334	17	hypothetical	hypothetical	ADJ
admet-628	334	18	70	70	NUM
admet-628	334	19	-	-	PUNCT
admet-628	334	20	kg	kg	NOUN
admet-628	334	21	human	human	ADJ
admet-628	334	22	receiving	receive	VERB
admet-628	334	23	75	75	NUM
admet-628	334	24	mg	mg	NOUN
admet-628	334	25	op	op	NOUN
admet-628	334	26	b.i.d	b.i.d	PROPN
admet-628	334	27	.	.	PUNCT
admet-628	335	1	for	for	ADP
admet-628	335	2	6	6	NUM
admet-628	335	3	days	day	NOUN
admet-628	335	4	.	.	PUNCT
admet-628	336	1	(	(	PUNCT
admet-628	336	2	_	_	PUNCT
admet-628	336	3	_	_	PUNCT
admet-628	337	1	_	_	PUNCT
admet-628	337	2	)	)	PUNCT
admet-628	337	3	model	model	NOUN
admet-628	337	4	-	-	PUNCT
admet-628	337	5	simulated	simulate	VERB
admet-628	337	6	oc	oc	ADP
admet-628	337	7	concentrations	concentration	NOUN
admet-628	337	8	figure	figure	VERB
admet-628	337	9	10	10	NUM
admet-628	337	10	.	.	PUNCT
admet-628	338	1	simulated	simulate	VERB
admet-628	338	2	op	op	NOUN
admet-628	338	3	concentration	concentration	NOUN
admet-628	338	4	-	-	PUNCT
admet-628	338	5	time	time	NOUN
admet-628	338	6	profiles	profile	NOUN
admet-628	338	7	in	in	ADP
admet-628	338	8	the	the	DET
admet-628	338	9	plasma	plasma	NOUN
admet-628	338	10	and	and	CCONJ
admet-628	338	11	tissues	tissue	NOUN
admet-628	338	12	of	of	ADP
admet-628	338	13	a	a	DET
admet-628	338	14	hypothetical	hypothetical	ADJ
admet-628	338	15	70	70	NUM
admet-628	338	16	-	-	PUNCT
admet-628	338	17	kg	kg	NOUN
admet-628	338	18	human	human	ADJ
admet-628	338	19	receiving	receive	VERB
admet-628	338	20	75	75	NUM
admet-628	338	21	mg	mg	NOUN
admet-628	338	22	op	op	NOUN
admet-628	338	23	b.i.d	b.i.d	PROPN
admet-628	338	24	.	.	PUNCT
admet-628	339	1	for	for	ADP
admet-628	339	2	6	6	NUM
admet-628	339	3	days	day	NOUN
admet-628	339	4	(	(	PUNCT
admet-628	339	5	_	_	PUNCT
admet-628	339	6	_	_	PUNCT
admet-628	339	7	_	_	PUNCT
admet-628	339	8	)	)	PUNCT
admet-628	339	9	model	model	NOUN
admet-628	339	10	-	-	PUNCT
admet-628	339	11	simulated	simulate	VERB
admet-628	339	12	op	op	NOUN
admet-628	339	13	concentrations	concentration	NOUN
admet-628	339	14	discussion	discussion	NOUN
admet-628	339	15	previous	previous	ADJ
admet-628	339	16	studies	study	NOUN
admet-628	339	17	have	have	AUX
admet-628	339	18	shown	show	VERB
admet-628	339	19	rats	rat	NOUN
admet-628	339	20	and	and	CCONJ
admet-628	339	21	humans	human	NOUN
admet-628	339	22	metabolize	metabolize	VERB
admet-628	339	23	op	op	NOUN
admet-628	339	24	differently	differently	ADV
admet-628	339	25	under	under	ADP
admet-628	339	26	in	in	ADP
admet-628	339	27	vitro	vitro	X
admet-628	339	28	incubation	incubation	NOUN
admet-628	339	29	conditions	condition	NOUN
admet-628	339	30	;	;	PUNCT
admet-628	339	31	op	op	NOUN
admet-628	339	32	is	be	AUX
admet-628	339	33	hydrolyzed	hydrolyze	VERB
admet-628	339	34	primarily	primarily	ADV
admet-628	339	35	to	to	AUX
admet-628	339	36	oc	oc	VERB
admet-628	339	37	by	by	ADP
admet-628	339	38	the	the	DET
admet-628	339	39	carboxylesterases	carboxylesterase	NOUN
admet-628	339	40	in	in	ADP
admet-628	339	41	rat	rat	NOUN
admet-628	339	42	plasma	plasma	NOUN
admet-628	339	43	but	but	CCONJ
admet-628	339	44	is	be	AUX
admet-628	339	45	not	not	PART
admet-628	339	46	hydrolysed	hydrolyse	VERB
admet-628	339	47	by	by	ADP
admet-628	339	48	the	the	DET
admet-628	339	49	carboxylesterases	carboxylesterase	NOUN
admet-628	339	50	in	in	ADP
admet-628	339	51	human	human	ADJ
admet-628	339	52	plasma	plasma	NOUN
admet-628	340	1	[	[	X
admet-628	340	2	23	23	NUM
admet-628	340	3	]	]	PUNCT
admet-628	340	4	.	.	PUNCT
admet-628	341	1	also	also	ADV
admet-628	341	2	,	,	PUNCT
admet-628	341	3	op	op	NOUN
admet-628	341	4	is	be	AUX
admet-628	341	5	metabolized	metabolize	VERB
admet-628	341	6	by	by	ADP
admet-628	341	7	the	the	DET
admet-628	341	8	hepatic	hepatic	ADJ
admet-628	341	9	cyp450	cyp450	NOUN
admet-628	341	10	system	system	NOUN
admet-628	341	11	of	of	ADP
admet-628	341	12	rats	rat	NOUN
admet-628	341	13	to	to	ADP
admet-628	341	14	minor	minor	ADJ
admet-628	341	15	metabolites	metabolite	NOUN
admet-628	341	16	[	[	PUNCT
admet-628	341	17	13	13	NUM
admet-628	341	18	]	]	PUNCT
admet-628	341	19	.	.	PUNCT
admet-628	342	1	in	in	ADP
admet-628	342	2	contrast	contrast	NOUN
admet-628	342	3	,	,	PUNCT
admet-628	342	4	although	although	SCONJ
admet-628	342	5	op	op	NOUN
admet-628	342	6	is	be	AUX
admet-628	342	7	metabolized	metabolize	VERB
admet-628	342	8	to	to	ADP
admet-628	342	9	oc	oc	NOUN
admet-628	342	10	by	by	ADP
admet-628	342	11	the	the	DET
admet-628	342	12	hepatic	hepatic	ADJ
admet-628	342	13	carboxylesterases	carboxylesterase	NOUN
admet-628	342	14	in	in	ADP
admet-628	342	15	humans	human	NOUN
admet-628	342	16	,	,	PUNCT
admet-628	342	17	the	the	DET
admet-628	342	18	cyp450	cyp450	NOUN
admet-628	342	19	system	system	NOUN
admet-628	342	20	does	do	AUX
admet-628	342	21	not	not	PART
admet-628	342	22	seem	seem	VERB
admet-628	342	23	to	to	PART
admet-628	342	24	involve	involve	VERB
admet-628	342	25	in	in	ADP
admet-628	342	26	its	its	PRON
admet-628	342	27	biotransformation	biotransformation	NOUN
admet-628	343	1	[	[	X
admet-628	343	2	14].thus	14].thu	NOUN
admet-628	343	3	,	,	PUNCT
admet-628	343	4	although	although	SCONJ
admet-628	343	5	op	op	NOUN
admet-628	343	6	g.	g.	PROPN
admet-628	343	7	gao	gao	PROPN
admet-628	343	8	et	et	PROPN
admet-628	343	9	al	al	PROPN
admet-628	343	10	.	.	PROPN
admet-628	343	11	admet	admet	PROPN
admet-628	343	12	&	&	CCONJ
admet-628	343	13	dmpk	dmpk	PROPN
admet-628	343	14	7(1	7(1	PROPN
admet-628	343	15	)	)	PUNCT
admet-628	343	16	(	(	PUNCT
admet-628	343	17	2019	2019	NUM
admet-628	343	18	)	)	PUNCT
admet-628	343	19	22	22	NUM
admet-628	343	20	-	-	SYM
admet-628	343	21	43	43	NUM
admet-628	343	22	36	36	NUM
admet-628	343	23	and	and	CCONJ
admet-628	343	24	oc	oc	PROPN
admet-628	343	25	are	be	AUX
admet-628	343	26	found	find	VERB
admet-628	343	27	in	in	ADP
admet-628	343	28	the	the	DET
admet-628	343	29	plasma	plasma	NOUN
admet-628	343	30	of	of	ADP
admet-628	343	31	humans	human	NOUN
admet-628	343	32	after	after	ADP
admet-628	343	33	administering	administer	VERB
admet-628	343	34	op	op	NOUN
admet-628	343	35	orally	orally	ADV
admet-628	343	36	[	[	X
admet-628	343	37	14,32	14,32	NUM
admet-628	343	38	]	]	X
admet-628	343	39	,	,	PUNCT
admet-628	343	40	only	only	ADV
admet-628	343	41	oc	oc	X
admet-628	343	42	and	and	CCONJ
admet-628	343	43	occasionally	occasionally	ADV
admet-628	343	44	op	op	NOUN
admet-628	343	45	are	be	AUX
admet-628	343	46	detected	detect	VERB
admet-628	343	47	in	in	ADP
admet-628	343	48	the	the	DET
admet-628	343	49	plasma	plasma	NOUN
admet-628	343	50	of	of	ADP
admet-628	343	51	rats	rat	NOUN
admet-628	343	52	(	(	PUNCT
admet-628	343	53	figs	fig	NOUN
admet-628	343	54	.	.	X
admet-628	344	1	3	3	NUM
admet-628	344	2	and	and	CCONJ
admet-628	344	3	4	4	NUM
admet-628	344	4	)	)	PUNCT
admet-628	344	5	.	.	PUNCT
admet-628	345	1	the	the	DET
admet-628	345	2	species	species	NOUN
admet-628	345	3	difference	difference	NOUN
admet-628	345	4	in	in	ADP
admet-628	345	5	op	op	NOUN
admet-628	345	6	metabolism	metabolism	NOUN
admet-628	345	7	may	may	AUX
admet-628	345	8	be	be	AUX
admet-628	345	9	related	relate	VERB
admet-628	345	10	to	to	ADP
admet-628	345	11	the	the	DET
admet-628	345	12	different	different	ADJ
admet-628	345	13	types	type	NOUN
admet-628	345	14	of	of	ADP
admet-628	345	15	carboxylesterases	carboxylesterase	NOUN
admet-628	345	16	in	in	ADP
admet-628	345	17	rats	rat	NOUN
admet-628	345	18	and	and	CCONJ
admet-628	345	19	humans	human	NOUN
admet-628	345	20	[	[	X
admet-628	345	21	41	41	NUM
admet-628	345	22	]	]	PUNCT
admet-628	345	23	.	.	PUNCT
admet-628	346	1	as	as	ADP
admet-628	346	2	a	a	DET
admet-628	346	3	result	result	NOUN
admet-628	346	4	,	,	PUNCT
admet-628	346	5	not	not	PART
admet-628	346	6	all	all	DET
admet-628	346	7	systemic	systemic	ADJ
admet-628	346	8	op	op	NOUN
admet-628	346	9	in	in	ADP
admet-628	346	10	humans	human	NOUN
admet-628	346	11	are	be	AUX
admet-628	346	12	converted	convert	VERB
admet-628	346	13	to	to	ADP
admet-628	346	14	oc	oc	NOUN
admet-628	346	15	by	by	ADP
admet-628	346	16	the	the	DET
admet-628	346	17	hepatic	hepatic	ADJ
admet-628	346	18	carboxylesterases	carboxylesterase	NOUN
admet-628	347	1	[	[	X
admet-628	347	2	14,32	14,32	NUM
admet-628	347	3	]	]	PUNCT
admet-628	347	4	.	.	PUNCT
admet-628	348	1	results	result	NOUN
admet-628	348	2	of	of	ADP
admet-628	348	3	our	our	PRON
admet-628	348	4	study	study	NOUN
admet-628	348	5	show	show	VERB
admet-628	348	6	the	the	DET
admet-628	348	7	kinetics	kinetic	NOUN
admet-628	348	8	of	of	ADP
admet-628	348	9	in	in	ADP
admet-628	348	10	vitro	vitro	X
admet-628	348	11	op	op	NOUN
admet-628	348	12	biotransformation	biotransformation	NOUN
admet-628	348	13	in	in	ADP
admet-628	348	14	rat	rat	NOUN
admet-628	348	15	plasma	plasma	NOUN
admet-628	348	16	can	can	AUX
admet-628	348	17	be	be	AUX
admet-628	348	18	adequately	adequately	ADV
admet-628	348	19	described	describe	VERB
admet-628	348	20	by	by	ADP
admet-628	348	21	the	the	DET
admet-628	348	22	michaelis	michaelis	ADJ
admet-628	348	23	-	-	PUNCT
admet-628	348	24	menten	menten	ADJ
admet-628	348	25	equation	equation	NOUN
admet-628	348	26	(	(	PUNCT
admet-628	348	27	table	table	NOUN
admet-628	348	28	2	2	NUM
admet-628	348	29	)	)	PUNCT
admet-628	348	30	.	.	PUNCT
admet-628	349	1	because	because	SCONJ
admet-628	349	2	carboxylesterase	carboxylesterase	NOUN
admet-628	349	3	activity	activity	NOUN
admet-628	349	4	varies	vary	VERB
admet-628	349	5	among	among	ADP
admet-628	349	6	different	different	ADJ
admet-628	349	7	animal	animal	NOUN
admet-628	349	8	species	specie	NOUN
admet-628	349	9	and	and	CCONJ
admet-628	349	10	organ	organ	NOUN
admet-628	349	11	sites	site	NOUN
admet-628	349	12	[	[	X
admet-628	349	13	41	41	NUM
admet-628	349	14	]	]	PUNCT
admet-628	349	15	,	,	PUNCT
admet-628	349	16	op	op	NOUN
admet-628	349	17	biotransformation	biotransformation	NOUN
admet-628	349	18	is	be	AUX
admet-628	349	19	assumed	assume	VERB
admet-628	349	20	to	to	PART
admet-628	349	21	take	take	VERB
admet-628	349	22	place	place	NOUN
admet-628	349	23	only	only	ADV
admet-628	349	24	in	in	ADP
admet-628	349	25	the	the	DET
admet-628	349	26	liver	liver	NOUN
admet-628	349	27	of	of	ADP
admet-628	349	28	rats	rat	NOUN
admet-628	349	29	during	during	ADP
admet-628	349	30	pbpk	pbpk	PROPN
admet-628	349	31	model	model	NOUN
admet-628	349	32	development	development	PROPN
admet-628	349	33	(	(	PUNCT
admet-628	349	34	fig	fig	NOUN
admet-628	349	35	.	.	PUNCT
admet-628	350	1	2	2	NUM
admet-628	350	2	)	)	PUNCT
admet-628	350	3	although	although	SCONJ
admet-628	350	4	the	the	DET
admet-628	350	5	km	km	NOUN
admet-628	350	6	(	(	PUNCT
admet-628	350	7	300	300	NUM
admet-628	350	8	mg	mg	PROPN
admet-628	350	9	/	/	SYM
admet-628	350	10	l	l	NOUN
admet-628	350	11	)	)	PUNCT
admet-628	350	12	and	and	CCONJ
admet-628	350	13	vmax	vmax	X
admet-628	350	14	(	(	PUNCT
admet-628	350	15	61.2	61.2	NUM
admet-628	350	16	mg	mg	NUM
admet-628	350	17	/	/	SYM
admet-628	350	18	h	h	NOUN
admet-628	350	19	)	)	PUNCT
admet-628	350	20	of	of	ADP
admet-628	350	21	the	the	DET
admet-628	350	22	rat	rat	NOUN
admet-628	350	23	pbpk	pbpk	NOUN
admet-628	350	24	model	model	NOUN
admet-628	350	25	have	have	AUX
admet-628	350	26	been	be	AUX
admet-628	350	27	derived	derive	VERB
admet-628	350	28	from	from	ADP
admet-628	350	29	rat	rat	NOUN
admet-628	350	30	plasma	plasma	NOUN
admet-628	350	31	incubation	incubation	NOUN
admet-628	350	32	studies	study	NOUN
admet-628	350	33	.	.	PUNCT
admet-628	351	1	in	in	ADP
admet-628	351	2	contrast	contrast	NOUN
admet-628	351	3	,	,	PUNCT
admet-628	351	4	the	the	DET
admet-628	351	5	km	km	NOUN
admet-628	351	6	(	(	PUNCT
admet-628	351	7	187	187	NUM
admet-628	351	8	µm	µm	NOUN
admet-628	351	9	,	,	PUNCT
admet-628	351	10	76mg	76mg	NOUN
admet-628	351	11	/	/	SYM
admet-628	351	12	l	l	NOUN
admet-628	351	13	)	)	PUNCT
admet-628	351	14	and	and	CCONJ
admet-628	351	15	vmax	vmax	X
admet-628	351	16	(	(	PUNCT
admet-628	351	17	114	114	NUM
admet-628	351	18	nmol	nmol	NOUN
admet-628	351	19	/	/	SYM
admet-628	351	20	mg	mg	PROPN
admet-628	351	21	/	/	SYM
admet-628	351	22	min	min	PROPN
admet-628	351	23	,	,	PUNCT
admet-628	351	24	2.6	2.6	NUM
admet-628	351	25	x	x	SYM
admet-628	351	26	105	105	NUM
admet-628	351	27	mg	mg	PROPN
admet-628	351	28	/	/	SYM
admet-628	351	29	h	h	NOUN
admet-628	351	30	)	)	PUNCT
admet-628	351	31	of	of	ADP
admet-628	351	32	the	the	DET
admet-628	351	33	human	human	ADJ
admet-628	351	34	pbpk	pbpk	PROPN
admet-628	351	35	model	model	NOUN
admet-628	351	36	have	have	AUX
admet-628	351	37	been	be	AUX
admet-628	351	38	obtained	obtain	VERB
admet-628	351	39	from	from	ADP
admet-628	351	40	in	in	ADP
admet-628	351	41	vitro	vitro	X
admet-628	351	42	human	human	ADJ
admet-628	351	43	liver	liver	NOUN
admet-628	351	44	microsomal	microsomal	ADJ
admet-628	351	45	studies	study	NOUN
admet-628	351	46	of	of	ADP
admet-628	351	47	shi	shi	PROPN
admet-628	351	48	et	et	PROPN
admet-628	351	49	al	al	PROPN
admet-628	351	50	.	.	PROPN
admet-628	351	51	,	,	PUNCT
admet-628	352	1	[	[	X
admet-628	352	2	2	2	NUM
admet-628	352	3	]	]	PUNCT
admet-628	352	4	(	(	PUNCT
admet-628	352	5	table	table	NOUN
admet-628	352	6	2	2	NUM
admet-628	352	7	)	)	PUNCT
admet-628	352	8	.	.	PUNCT
admet-628	353	1	our	our	PRON
admet-628	353	2	studies	study	NOUN
admet-628	353	3	also	also	ADV
admet-628	353	4	show	show	VERB
admet-628	353	5	that	that	SCONJ
admet-628	353	6	the	the	DET
admet-628	353	7	cmax	cmax	NOUN
admet-628	353	8	of	of	ADP
admet-628	353	9	oc	oc	NOUN
admet-628	353	10	in	in	ADP
admet-628	353	11	the	the	DET
admet-628	353	12	organs	organ	NOUN
admet-628	353	13	/	/	SYM
admet-628	353	14	tissues	tissue	NOUN
admet-628	353	15	of	of	ADP
admet-628	353	16	rats	rat	NOUN
admet-628	353	17	decreases	decrease	VERB
admet-628	353	18	in	in	ADP
admet-628	353	19	the	the	DET
admet-628	353	20	order	order	NOUN
admet-628	353	21	of	of	ADP
admet-628	353	22	liver	liver	NOUN
admet-628	353	23	>	>	X
admet-628	353	24	kidney	kidney	PROPN
admet-628	353	25	>	>	X
admet-628	353	26	lung	lung	PROPN
admet-628	353	27	>	>	X
admet-628	353	28	plasma	plasma	PROPN
admet-628	353	29	>	>	X
admet-628	353	30	brain	brain	NOUN
admet-628	353	31	.	.	PUNCT
admet-628	354	1	similar	similar	ADJ
admet-628	354	2	orders	order	NOUN
admet-628	354	3	of	of	ADP
admet-628	354	4	radioactivity	radioactivity	NOUN
admet-628	354	5	distribution	distribution	NOUN
admet-628	354	6	were	be	AUX
admet-628	354	7	observed	observe	VERB
admet-628	354	8	in	in	ADP
admet-628	354	9	the	the	DET
admet-628	354	10	ferrets	ferret	NOUN
admet-628	354	11	[	[	X
admet-628	354	12	14	14	NUM
admet-628	354	13	]	]	PUNCT
admet-628	354	14	and	and	CCONJ
admet-628	354	15	mice	mouse	NOUN
admet-628	354	16	[	[	X
admet-628	354	17	15	15	NUM
admet-628	354	18	]	]	PUNCT
admet-628	354	19	after	after	ADP
admet-628	354	20	oral	oral	ADJ
admet-628	354	21	administration	administration	NOUN
admet-628	354	22	of	of	ADP
admet-628	354	23	radiolabeled	radiolabele	VERB
admet-628	354	24	op	op	NOUN
admet-628	354	25	.	.	PUNCT
admet-628	355	1	however	however	ADV
admet-628	355	2	,	,	PUNCT
admet-628	355	3	because	because	SCONJ
admet-628	355	4	the	the	DET
admet-628	355	5	radioactivity	radioactivity	NOUN
admet-628	355	6	is	be	AUX
admet-628	355	7	comprised	comprise	VERB
admet-628	355	8	of	of	ADP
admet-628	355	9	a	a	DET
admet-628	355	10	mixture	mixture	NOUN
admet-628	355	11	of	of	ADP
admet-628	355	12	op	op	NOUN
admet-628	355	13	,	,	PUNCT
admet-628	355	14	oc	oc	NOUN
admet-628	355	15	and	and	CCONJ
admet-628	355	16	other	other	ADJ
admet-628	355	17	metabolites	metabolite	NOUN
admet-628	355	18	,	,	PUNCT
admet-628	355	19	it	it	PRON
admet-628	355	20	is	be	AUX
admet-628	355	21	not	not	PART
admet-628	355	22	possible	possible	ADJ
admet-628	355	23	to	to	PART
admet-628	355	24	quantify	quantify	VERB
admet-628	355	25	op	op	NOUN
admet-628	355	26	and	and	CCONJ
admet-628	355	27	oc	oc	AUX
admet-628	355	28	individually	individually	ADV
admet-628	355	29	based	base	VERB
admet-628	355	30	on	on	ADP
admet-628	355	31	the	the	DET
admet-628	355	32	results	result	NOUN
admet-628	355	33	of	of	ADP
admet-628	355	34	the	the	DET
admet-628	355	35	tissue	tissue	NOUN
admet-628	355	36	distribution	distribution	NOUN
admet-628	355	37	studies	study	NOUN
admet-628	355	38	.	.	PUNCT
admet-628	356	1	our	our	PRON
admet-628	356	2	pbpk	pbpk	PROPN
admet-628	356	3	model	model	NOUN
admet-628	356	4	provides	provide	VERB
admet-628	356	5	a	a	DET
admet-628	356	6	means	mean	NOUN
admet-628	356	7	to	to	PART
admet-628	356	8	integrate	integrate	VERB
admet-628	356	9	relevant	relevant	ADJ
admet-628	356	10	in	in	ADP
admet-628	356	11	vitro	vitro	X
admet-628	356	12	and	and	CCONJ
admet-628	356	13	in	in	ADP
admet-628	356	14	vivo	vivo	ADJ
admet-628	356	15	data	datum	NOUN
admet-628	356	16	into	into	ADP
admet-628	356	17	a	a	DET
admet-628	356	18	coherent	coherent	ADJ
admet-628	356	19	description	description	NOUN
admet-628	356	20	of	of	ADP
admet-628	356	21	op	op	NOUN
admet-628	356	22	/	/	SYM
admet-628	356	23	oc	oc	VERB
admet-628	356	24	pharmacokinetics	pharmacokinetic	NOUN
admet-628	356	25	for	for	ADP
admet-628	356	26	the	the	DET
admet-628	356	27	whole	whole	ADJ
admet-628	356	28	animal	animal	NOUN
admet-628	356	29	.	.	PUNCT
admet-628	357	1	the	the	DET
admet-628	357	2	model	model	NOUN
admet-628	357	3	is	be	AUX
admet-628	357	4	comprised	comprise	VERB
admet-628	357	5	of	of	ADP
admet-628	357	6	an	an	DET
admet-628	357	7	op	op	NOUN
admet-628	357	8	and	and	CCONJ
admet-628	357	9	an	an	DET
admet-628	357	10	oc	oc	NOUN
admet-628	357	11	sub	sub	NOUN
admet-628	357	12	-	-	NOUN
admet-628	357	13	models	model	NOUN
admet-628	357	14	(	(	PUNCT
admet-628	357	15	fig	fig	NOUN
admet-628	357	16	.	.	PUNCT
admet-628	358	1	2	2	NUM
admet-628	358	2	)	)	PUNCT
admet-628	358	3	.	.	PUNCT
admet-628	359	1	model	model	NOUN
admet-628	359	2	performance	performance	NOUN
admet-628	359	3	is	be	AUX
admet-628	359	4	evaluated	evaluate	VERB
admet-628	359	5	by	by	ADP
admet-628	359	6	comparing	compare	VERB
admet-628	359	7	simulation	simulation	NOUN
admet-628	359	8	results	result	NOUN
admet-628	359	9	with	with	ADP
admet-628	359	10	experimental	experimental	ADJ
admet-628	359	11	data	datum	NOUN
admet-628	359	12	.	.	PUNCT
admet-628	360	1	the	the	DET
admet-628	360	2	proposed	propose	VERB
admet-628	360	3	pbpk	pbpk	NOUN
admet-628	360	4	model	model	NOUN
admet-628	360	5	is	be	AUX
admet-628	360	6	quite	quite	ADV
admet-628	360	7	complex	complex	ADJ
admet-628	360	8	but	but	CCONJ
admet-628	360	9	can	can	AUX
admet-628	360	10	be	be	AUX
admet-628	360	11	collapsed	collapse	VERB
admet-628	360	12	into	into	ADP
admet-628	360	13	a	a	DET
admet-628	360	14	less	less	ADV
admet-628	360	15	complex	complex	ADJ
admet-628	360	16	model	model	NOUN
admet-628	360	17	by	by	ADP
admet-628	360	18	consolidating	consolidate	VERB
admet-628	360	19	the	the	DET
admet-628	360	20	various	various	ADJ
admet-628	360	21	tissues	tissue	NOUN
admet-628	360	22	/	/	SYM
admet-628	360	23	organs	organ	NOUN
admet-628	360	24	into	into	ADP
admet-628	360	25	rich	rich	ADJ
admet-628	360	26	and	and	CCONJ
admet-628	360	27	poor	poor	ADJ
admet-628	360	28	perfusion	perfusion	NOUN
admet-628	360	29	compartments	compartment	NOUN
admet-628	360	30	.	.	PUNCT
admet-628	361	1	we	we	PRON
admet-628	361	2	have	have	AUX
admet-628	361	3	chosen	choose	VERB
admet-628	361	4	a	a	DET
admet-628	361	5	more	more	ADV
admet-628	361	6	complex	complex	ADJ
admet-628	361	7	model	model	NOUN
admet-628	361	8	for	for	ADP
admet-628	361	9	the	the	DET
admet-628	361	10	present	present	ADJ
admet-628	361	11	study	study	NOUN
admet-628	361	12	because	because	SCONJ
admet-628	361	13	it	it	PRON
admet-628	361	14	possesses	possess	VERB
admet-628	361	15	the	the	DET
admet-628	361	16	structural	structural	ADJ
admet-628	361	17	details	detail	NOUN
admet-628	361	18	to	to	PART
admet-628	361	19	address	address	VERB
admet-628	361	20	the	the	DET
admet-628	361	21	pharmacological	pharmacological	ADJ
admet-628	361	22	and	and	CCONJ
admet-628	361	23	toxicological	toxicological	ADJ
admet-628	361	24	effects	effect	NOUN
admet-628	361	25	of	of	ADP
admet-628	361	26	op	op	NOUN
admet-628	361	27	in	in	ADP
admet-628	361	28	humans	human	NOUN
admet-628	361	29	.	.	PUNCT
admet-628	362	1	in	in	ADP
admet-628	362	2	addition	addition	NOUN
admet-628	362	3	,	,	PUNCT
admet-628	362	4	although	although	SCONJ
admet-628	362	5	it	it	PRON
admet-628	362	6	is	be	AUX
admet-628	362	7	more	more	ADV
admet-628	362	8	difficult	difficult	ADJ
admet-628	362	9	to	to	PART
admet-628	362	10	fit	fit	VERB
admet-628	362	11	available	available	ADJ
admet-628	362	12	experimental	experimental	ADJ
admet-628	362	13	data	datum	NOUN
admet-628	362	14	to	to	ADP
admet-628	362	15	a	a	DET
admet-628	362	16	complex	complex	ADJ
admet-628	362	17	model	model	NOUN
admet-628	362	18	,	,	PUNCT
admet-628	362	19	the	the	DET
admet-628	362	20	derived	derived	ADJ
admet-628	362	21	parameter	parameter	NOUN
admet-628	362	22	values	value	NOUN
admet-628	362	23	from	from	ADP
admet-628	362	24	a	a	DET
admet-628	362	25	complex	complex	ADJ
admet-628	362	26	model	model	NOUN
admet-628	362	27	are	be	AUX
admet-628	362	28	more	more	ADV
admet-628	362	29	accurate	accurate	ADJ
admet-628	362	30	than	than	ADP
admet-628	362	31	those	those	PRON
admet-628	362	32	derived	derive	VERB
admet-628	362	33	from	from	ADP
admet-628	362	34	a	a	DET
admet-628	362	35	less	less	ADV
admet-628	362	36	complex	complex	ADJ
admet-628	362	37	model	model	NOUN
admet-628	362	38	[	[	X
admet-628	362	39	19	19	NUM
admet-628	362	40	]	]	PUNCT
admet-628	362	41	.	.	PUNCT
admet-628	363	1	more	more	ADJ
admet-628	363	2	than	than	ADP
admet-628	363	3	80	80	NUM
admet-628	363	4	parameter	parameter	NOUN
admet-628	363	5	values	value	NOUN
admet-628	363	6	are	be	AUX
admet-628	363	7	required	require	VERB
admet-628	363	8	to	to	PART
admet-628	363	9	implement	implement	VERB
admet-628	363	10	the	the	DET
admet-628	363	11	pbpk	pbpk	ADJ
admet-628	363	12	model	model	NOUN
admet-628	363	13	of	of	ADP
admet-628	363	14	op	op	NOUN
admet-628	363	15	/	/	SYM
admet-628	363	16	oc	oc	PROPN
admet-628	363	17	.	.	PUNCT
admet-628	364	1	there	there	PRON
admet-628	364	2	is	be	VERB
admet-628	364	3	always	always	ADV
admet-628	364	4	uncertainty	uncertainty	NOUN
admet-628	364	5	regarding	regard	VERB
admet-628	364	6	whether	whether	SCONJ
admet-628	364	7	they	they	PRON
admet-628	364	8	actually	actually	ADV
admet-628	364	9	represent	represent	VERB
admet-628	364	10	true	true	ADJ
admet-628	364	11	parameter	parameter	NOUN
admet-628	364	12	values	value	NOUN
admet-628	364	13	.	.	PUNCT
admet-628	365	1	we	we	PRON
admet-628	365	2	have	have	AUX
admet-628	365	3	used	use	VERB
admet-628	365	4	the	the	DET
admet-628	365	5	analytical	analytical	ADJ
admet-628	365	6	sensitivity	sensitivity	NOUN
admet-628	365	7	analysis	analysis	NOUN
admet-628	365	8	[	[	X
admet-628	365	9	39	39	NUM
admet-628	365	10	]	]	PUNCT
admet-628	365	11	to	to	PART
admet-628	365	12	identify	identify	VERB
admet-628	365	13	the	the	DET
admet-628	365	14	model	model	NOUN
admet-628	365	15	parameters	parameter	NOUN
admet-628	365	16	that	that	PRON
admet-628	365	17	significantly	significantly	ADV
admet-628	365	18	affect	affect	VERB
admet-628	365	19	the	the	DET
admet-628	365	20	oc	oc	NOUN
admet-628	365	21	dose	dose	NOUN
admet-628	365	22	metrics	metric	NOUN
admet-628	365	23	in	in	ADP
admet-628	365	24	the	the	DET
admet-628	365	25	lungs	lung	NOUN
admet-628	365	26	and	and	CCONJ
admet-628	365	27	plasma	plasma	NOUN
admet-628	365	28	.	.	PUNCT
admet-628	366	1	as	as	SCONJ
admet-628	366	2	shown	show	VERB
admet-628	366	3	in	in	ADP
admet-628	366	4	table	table	NOUN
admet-628	366	5	3	3	NUM
admet-628	366	6	,	,	PUNCT
admet-628	366	7	none	none	NOUN
admet-628	366	8	of	of	ADP
admet-628	366	9	the	the	DET
admet-628	366	10	parameter	parameter	NOUN
admet-628	366	11	has	have	VERB
admet-628	366	12	an	an	DET
admet-628	366	13	absolute	absolute	ADJ
admet-628	366	14	sensitivity	sensitivity	NOUN
admet-628	366	15	coefficient	coefficient	NOUN
admet-628	366	16	significantly	significantly	ADV
admet-628	366	17	greater	great	ADJ
admet-628	366	18	than	than	ADP
admet-628	366	19	1.0	1.0	NUM
admet-628	366	20	.	.	PUNCT
admet-628	367	1	this	this	PRON
admet-628	367	2	indicates	indicate	VERB
admet-628	367	3	that	that	SCONJ
admet-628	367	4	there	there	PRON
admet-628	367	5	is	be	VERB
admet-628	367	6	no	no	DET
admet-628	367	7	amplification	amplification	NOUN
admet-628	367	8	of	of	ADP
admet-628	367	9	errors	error	NOUN
admet-628	367	10	from	from	ADP
admet-628	367	11	the	the	DET
admet-628	367	12	input	input	NOUN
admet-628	367	13	parameters	parameter	NOUN
admet-628	367	14	in	in	ADP
admet-628	367	15	the	the	DET
admet-628	367	16	prediction	prediction	NOUN
admet-628	367	17	of	of	ADP
admet-628	367	18	oc	oc	PART
admet-628	367	19	dose	dose	NOUN
admet-628	367	20	metrics	metric	NOUN
admet-628	367	21	in	in	ADP
admet-628	367	22	these	these	DET
admet-628	367	23	target	target	NOUN
admet-628	367	24	organs	organ	NOUN
admet-628	367	25	.	.	PUNCT
admet-628	368	1	in	in	ADP
admet-628	368	2	other	other	ADJ
admet-628	368	3	words	word	NOUN
admet-628	368	4	,	,	PUNCT
admet-628	368	5	the	the	DET
admet-628	368	6	oc	oc	NOUN
admet-628	368	7	dose	dose	NOUN
admet-628	368	8	metrics	metric	NOUN
admet-628	368	9	in	in	ADP
admet-628	368	10	the	the	DET
admet-628	368	11	lungs	lung	NOUN
admet-628	368	12	and	and	CCONJ
admet-628	368	13	plasma	plasma	NOUN
admet-628	368	14	are	be	AUX
admet-628	368	15	predicted	predict	VERB
admet-628	368	16	with	with	ADP
admet-628	368	17	a	a	DET
admet-628	368	18	certain	certain	ADJ
admet-628	368	19	degree	degree	NOUN
admet-628	368	20	of	of	ADP
admet-628	368	21	confidence	confidence	NOUN
admet-628	368	22	even	even	ADV
admet-628	368	23	though	though	SCONJ
admet-628	368	24	some	some	PRON
admet-628	368	25	of	of	ADP
admet-628	368	26	the	the	DET
admet-628	368	27	model	model	NOUN
admet-628	368	28	parameter	parameter	NOUN
admet-628	368	29	values	value	NOUN
admet-628	368	30	may	may	AUX
admet-628	368	31	have	have	AUX
admet-628	368	32	been	be	AUX
admet-628	368	33	determined	determine	VERB
admet-628	368	34	inaccurately	inaccurately	ADV
admet-628	368	35	.	.	PUNCT
admet-628	369	1	the	the	DET
admet-628	369	2	pbpk	pbpk	PROPN
admet-628	369	3	model	model	NOUN
admet-628	369	4	in	in	ADP
admet-628	369	5	rat	rat	NOUN
admet-628	369	6	was	be	AUX
admet-628	369	7	developed	develop	VERB
admet-628	369	8	majorly	majorly	ADV
admet-628	369	9	with	with	SCONJ
admet-628	369	10	the	the	DET
admet-628	369	11	dataset	dataset	NOUN
admet-628	369	12	following	follow	VERB
admet-628	369	13	orally	orally	ADV
admet-628	369	14	administered	administer	VERB
admet-628	369	15	10	10	NUM
admet-628	369	16	mg	mg	PROPN
admet-628	369	17	/	/	SYM
admet-628	369	18	kg	kg	PROPN
admet-628	369	19	,	,	PUNCT
admet-628	369	20	among	among	ADP
admet-628	369	21	all	all	DET
admet-628	369	22	the	the	DET
admet-628	369	23	parameters	parameter	NOUN
admet-628	369	24	,	,	PUNCT
admet-628	369	25	distribution	distribution	NOUN
admet-628	369	26	,	,	PUNCT
admet-628	369	27	metabolism	metabolism	NOUN
admet-628	369	28	and	and	CCONJ
admet-628	369	29	elimination	elimination	NOUN
admet-628	369	30	parameters	parameter	NOUN
admet-628	369	31	were	be	AUX
admet-628	369	32	basically	basically	ADV
admet-628	369	33	from	from	ADP
admet-628	369	34	experimental	experimental	ADJ
admet-628	369	35	data	datum	NOUN
admet-628	369	36	while	while	SCONJ
admet-628	369	37	absorption	absorption	NOUN
admet-628	369	38	related	related	ADJ
admet-628	369	39	parameters	parameter	NOUN
admet-628	369	40	were	be	AUX
admet-628	369	41	allowed	allow	VERB
admet-628	369	42	to	to	PART
admet-628	369	43	be	be	AUX
admet-628	369	44	optimized	optimize	VERB
admet-628	369	45	to	to	ADP
admet-628	369	46	a	a	DET
admet-628	369	47	certain	certain	ADJ
admet-628	369	48	extent	extent	NOUN
admet-628	369	49	,	,	PUNCT
admet-628	369	50	the	the	DET
admet-628	369	51	model	model	NOUN
admet-628	369	52	could	could	AUX
admet-628	369	53	predict	predict	VERB
admet-628	369	54	the	the	DET
admet-628	369	55	tissue	tissue	NOUN
admet-628	369	56	distributions	distribution	NOUN
admet-628	369	57	satisfactorily	satisfactorily	ADV
admet-628	369	58	for	for	ADP
admet-628	369	59	10	10	NUM
admet-628	369	60	mg	mg	NUM
admet-628	369	61	/	/	SYM
admet-628	369	62	kg	kg	PROPN
admet-628	369	63	and	and	CCONJ
admet-628	369	64	two	two	NUM
admet-628	369	65	published	publish	VERB
admet-628	369	66	rat	rat	NOUN
admet-628	369	67	plasma	plasma	NOUN
admet-628	369	68	datasets	dataset	NOUN
admet-628	369	69	[	[	X
admet-628	369	70	15,16	15,16	NUM
admet-628	369	71	]	]	PUNCT
admet-628	369	72	.	.	PUNCT
admet-628	370	1	while	while	SCONJ
admet-628	370	2	the	the	DET
admet-628	370	3	developed	develop	VERB
admet-628	370	4	model	model	NOUN
admet-628	370	5	was	be	AUX
admet-628	370	6	used	use	VERB
admet-628	370	7	to	to	PART
admet-628	370	8	simulate	simulate	VERB
admet-628	370	9	the	the	DET
admet-628	370	10	tissue	tissue	NOUN
admet-628	370	11	exposure	exposure	NOUN
admet-628	370	12	in	in	ADP
admet-628	370	13	rat	rat	NOUN
admet-628	370	14	following	follow	VERB
admet-628	370	15	orally	orally	ADV
admet-628	370	16	administered	administer	VERB
admet-628	370	17	50	50	NUM
admet-628	370	18	mg	mg	PROPN
admet-628	370	19	/	/	SYM
admet-628	370	20	kg	kg	PROPN
admet-628	370	21	for	for	ADP
admet-628	370	22	validation	validation	NOUN
admet-628	370	23	,	,	PUNCT
admet-628	370	24	the	the	DET
admet-628	370	25	simulations	simulation	NOUN
admet-628	370	26	seemed	seem	VERB
admet-628	370	27	to	to	PART
admet-628	370	28	have	have	VERB
admet-628	370	29	the	the	DET
admet-628	370	30	tendency	tendency	NOUN
admet-628	370	31	of	of	ADP
admet-628	370	32	overestimating	overestimate	VERB
admet-628	370	33	cmax	cmax	NOUN
admet-628	370	34	and	and	CCONJ
admet-628	370	35	underestimating	underestimate	VERB
admet-628	370	36	auc	auc	NOUN
admet-628	370	37	for	for	ADP
admet-628	370	38	both	both	DET
admet-628	370	39	op	op	NOUN
admet-628	370	40	and	and	CCONJ
admet-628	370	41	oc	oc	NOUN
admet-628	370	42	in	in	ADP
admet-628	370	43	kidney	kidney	NOUN
admet-628	370	44	and	and	CCONJ
admet-628	370	45	lung	lung	NOUN
admet-628	370	46	,	,	PUNCT
admet-628	370	47	the	the	DET
admet-628	370	48	discrepancy	discrepancy	NOUN
admet-628	370	49	might	might	AUX
admet-628	370	50	be	be	AUX
admet-628	370	51	related	relate	VERB
admet-628	370	52	to	to	ADP
admet-628	370	53	the	the	DET
admet-628	370	54	higher	high	ADJ
admet-628	370	55	optimized	optimize	VERB
admet-628	370	56	parameters	parameter	NOUN
admet-628	370	57	related	relate	VERB
admet-628	370	58	to	to	ADP
admet-628	370	59	absorption	absorption	NOUN
admet-628	370	60	(	(	PUNCT
admet-628	370	61	ka	ka	PROPN
admet-628	370	62	,	,	PUNCT
admet-628	370	63	f	f	NOUN
admet-628	370	64	)	)	PUNCT
admet-628	370	65	and	and	CCONJ
admet-628	370	66	renal	renal	ADJ
admet-628	370	67	clearance	clearance	NOUN
admet-628	370	68	of	of	ADP
admet-628	370	69	op	op	NOUN
admet-628	370	70	(	(	PUNCT
admet-628	370	71	clp	clp	PROPN
admet-628	370	72	)	)	PUNCT
admet-628	370	73	compared	compare	VERB
admet-628	370	74	to	to	ADP
admet-628	370	75	the	the	DET
admet-628	370	76	reported	report	VERB
admet-628	370	77	values	value	NOUN
admet-628	370	78	.	.	PUNCT
admet-628	371	1	considering	consider	VERB
admet-628	371	2	the	the	DET
admet-628	371	3	satisfactory	satisfactory	ADJ
admet-628	371	4	simulations	simulation	NOUN
admet-628	371	5	for	for	ADP
admet-628	371	6	exposure	exposure	NOUN
admet-628	371	7	at	at	ADP
admet-628	371	8	10	10	NUM
admet-628	371	9	mg	mg	NUM
admet-628	371	10	/	/	SYM
admet-628	371	11	kg	kg	PROPN
admet-628	371	12	admet	admet	PROPN
admet-628	371	13	&	&	CCONJ
admet-628	371	14	dmpk	dmpk	PROPN
admet-628	371	15	7(1	7(1	PROPN
admet-628	371	16	)	)	PUNCT
admet-628	371	17	(	(	PUNCT
admet-628	371	18	2019	2019	NUM
admet-628	371	19	)	)	PUNCT
admet-628	371	20	22	22	NUM
admet-628	371	21	-	-	SYM
admet-628	371	22	43	43	NUM
admet-628	371	23	a	a	DET
admet-628	371	24	physiologically	physiologically	ADV
admet-628	371	25	-	-	PUNCT
admet-628	371	26	based	base	VERB
admet-628	371	27	pharmacokinetic	pharmacokinetic	ADJ
admet-628	371	28	model	model	NOUN
admet-628	371	29	for	for	ADP
admet-628	371	30	oseltamivir	oseltamivir	PROPN
admet-628	371	31	doi	doi	PROPN
admet-628	371	32	:	:	PUNCT
admet-628	371	33	10.5599	10.5599	NUM
admet-628	371	34	/	/	SYM
admet-628	371	35	admet.628	admet.628	PROPN
admet-628	371	36	37	37	NUM
admet-628	371	37	and	and	CCONJ
admet-628	371	38	the	the	DET
admet-628	371	39	uncertainty	uncertainty	NOUN
admet-628	371	40	of	of	ADP
admet-628	371	41	absorption	absorption	NOUN
admet-628	371	42	processes	process	NOUN
admet-628	371	43	,	,	PUNCT
admet-628	371	44	this	this	PRON
admet-628	371	45	leaves	leave	VERB
admet-628	371	46	space	space	NOUN
admet-628	371	47	for	for	ADP
admet-628	371	48	further	further	ADJ
admet-628	371	49	refinement	refinement	NOUN
admet-628	371	50	or	or	CCONJ
admet-628	371	51	validation	validation	NOUN
admet-628	371	52	.	.	PUNCT
admet-628	372	1	on	on	ADP
admet-628	372	2	the	the	DET
admet-628	372	3	other	other	ADJ
admet-628	372	4	hand	hand	NOUN
admet-628	372	5	,	,	PUNCT
admet-628	372	6	the	the	DET
admet-628	372	7	current	current	ADJ
admet-628	372	8	pbpk	pbpk	NOUN
admet-628	372	9	model	model	NOUN
admet-628	372	10	will	will	AUX
admet-628	372	11	be	be	AUX
admet-628	372	12	definitely	definitely	ADV
admet-628	372	13	improved	improve	VERB
admet-628	372	14	with	with	ADP
admet-628	372	15	further	further	ADJ
admet-628	372	16	specific	specific	ADJ
admet-628	372	17	parameters	parameter	NOUN
admet-628	372	18	for	for	ADP
admet-628	372	19	metabolism	metabolism	NOUN
admet-628	372	20	considering	consider	VERB
admet-628	372	21	different	different	ADJ
admet-628	372	22	enzymes	enzyme	NOUN
admet-628	372	23	and	and	CCONJ
admet-628	372	24	happening	happen	VERB
admet-628	372	25	sites	site	NOUN
admet-628	372	26	between	between	ADP
admet-628	372	27	human	human	NOUN
admet-628	372	28	and	and	CCONJ
admet-628	372	29	rat	rat	NOUN
admet-628	372	30	,	,	PUNCT
admet-628	372	31	absorption	absorption	NOUN
admet-628	372	32	/	/	SYM
admet-628	372	33	distribution	distribution	NOUN
admet-628	372	34	parameters	parameter	NOUN
admet-628	372	35	related	relate	VERB
admet-628	372	36	to	to	ADP
admet-628	372	37	p	p	NOUN
admet-628	372	38	-	-	PUNCT
admet-628	372	39	gp	gp	NOUN
admet-628	372	40	transporters	transporter	NOUN
admet-628	372	41	(	(	PUNCT
admet-628	372	42	brain	brain	NOUN
admet-628	372	43	/	/	SYM
admet-628	372	44	gi	gi	NOUN
admet-628	372	45	tract	tract	NOUN
admet-628	372	46	)	)	PUNCT
admet-628	373	1	[	[	X
admet-628	373	2	42	42	NUM
admet-628	373	3	-	-	SYM
admet-628	373	4	44	44	NUM
admet-628	373	5	]	]	PUNCT
admet-628	373	6	and	and	CCONJ
admet-628	373	7	elimination	elimination	NOUN
admet-628	373	8	parameters	parameter	NOUN
admet-628	373	9	related	relate	VERB
admet-628	373	10	to	to	ADP
admet-628	373	11	organic	organic	ADJ
admet-628	373	12	anion	anion	NOUN
admet-628	373	13	transporters	transporter	NOUN
admet-628	373	14	(	(	PUNCT
admet-628	373	15	oat	oat	NOUN
admet-628	373	16	)	)	PUNCT
admet-628	373	17	in	in	ADP
admet-628	373	18	kidney	kidney	NOUN
admet-628	373	19	[	[	X
admet-628	373	20	45	45	NUM
admet-628	373	21	]	]	PUNCT
admet-628	373	22	.	.	PUNCT
admet-628	374	1	the	the	DET
admet-628	374	2	therapeutic	therapeutic	ADJ
admet-628	374	3	effects	effect	NOUN
admet-628	374	4	of	of	ADP
admet-628	374	5	op	op	NOUN
admet-628	374	6	in	in	ADP
admet-628	374	7	humans	human	NOUN
admet-628	374	8	are	be	AUX
admet-628	374	9	related	relate	VERB
admet-628	374	10	to	to	ADP
admet-628	374	11	the	the	DET
admet-628	374	12	inhibition	inhibition	NOUN
admet-628	374	13	of	of	ADP
admet-628	374	14	neuraminidase	neuraminidase	NOUN
admet-628	374	15	activity	activity	NOUN
admet-628	374	16	of	of	ADP
admet-628	374	17	the	the	DET
admet-628	374	18	influenza	influenza	NOUN
admet-628	374	19	virus	virus	NOUN
admet-628	374	20	.	.	PUNCT
admet-628	375	1	in	in	ADP
admet-628	375	2	other	other	ADJ
admet-628	375	3	words	word	NOUN
admet-628	375	4	,	,	PUNCT
admet-628	375	5	inhibition	inhibition	NOUN
admet-628	375	6	of	of	ADP
admet-628	375	7	neuraminidase	neuraminidase	NOUN
admet-628	375	8	activity	activity	NOUN
admet-628	375	9	by	by	ADP
admet-628	375	10	oc	oc	NOUN
admet-628	375	11	will	will	AUX
admet-628	375	12	result	result	VERB
admet-628	375	13	in	in	ADP
admet-628	375	14	a	a	DET
admet-628	375	15	decrease	decrease	NOUN
admet-628	375	16	or	or	CCONJ
admet-628	375	17	even	even	ADV
admet-628	375	18	stoppage	stoppage	NOUN
admet-628	375	19	of	of	ADP
admet-628	375	20	progeny	progeny	ADJ
admet-628	375	21	virion	virion	NOUN
admet-628	375	22	release	release	NOUN
admet-628	375	23	and	and	CCONJ
admet-628	375	24	propagation	propagation	NOUN
admet-628	375	25	in	in	ADP
admet-628	375	26	the	the	DET
admet-628	375	27	respiratory	respiratory	ADJ
admet-628	375	28	tract	tract	NOUN
admet-628	375	29	.	.	PUNCT
admet-628	376	1	thus	thus	ADV
admet-628	376	2	op	op	NOUN
admet-628	376	3	efficacy	efficacy	NOUN
admet-628	376	4	may	may	AUX
admet-628	376	5	be	be	AUX
admet-628	376	6	evaluated	evaluate	VERB
admet-628	376	7	by	by	ADP
admet-628	376	8	comparing	compare	VERB
admet-628	376	9	the	the	DET
admet-628	376	10	dosimetry	dosimetry	NOUN
admet-628	376	11	of	of	ADP
admet-628	376	12	oc	oc	NOUN
admet-628	376	13	in	in	ADP
admet-628	376	14	the	the	DET
admet-628	376	15	lung	lung	NOUN
admet-628	376	16	and	and	CCONJ
admet-628	376	17	the	the	DET
admet-628	376	18	ic50	ic50	PROPN
admet-628	376	19	of	of	ADP
admet-628	376	20	oc	oc	NOUN
admet-628	376	21	of	of	ADP
admet-628	376	22	neuraminidases	neuraminidase	NOUN
admet-628	376	23	.	.	PUNCT
admet-628	377	1	he	he	PRON
admet-628	377	2	et	et	PROPN
admet-628	377	3	al	al	PROPN
admet-628	377	4	.	.	PROPN
admet-628	377	5	,	,	PUNCT
admet-628	378	1	[	[	X
admet-628	378	2	14	14	NUM
admet-628	378	3	]	]	PUNCT
admet-628	378	4	showed	show	VERB
admet-628	378	5	that	that	SCONJ
admet-628	378	6	the	the	DET
admet-628	378	7	ic50	ic50	PROPN
admet-628	378	8	of	of	ADP
admet-628	378	9	oc	oc	NOUN
admet-628	378	10	for	for	ADP
admet-628	378	11	neuraminidases	neuraminidase	NOUN
admet-628	378	12	range	range	VERB
admet-628	378	13	from	from	ADP
admet-628	378	14	0.3	0.3	NUM
admet-628	378	15	-	-	SYM
admet-628	378	16	2.0	2.0	NUM
admet-628	378	17	nm	nm	NOUN
admet-628	378	18	(	(	PUNCT
admet-628	378	19	0.08	0.08	NUM
admet-628	378	20	-	-	SYM
admet-628	378	21	0.28	0.28	NUM
admet-628	378	22	ng	ng	PROPN
admet-628	378	23	/	/	SYM
admet-628	378	24	ml	ml	NOUN
admet-628	378	25	)	)	PUNCT
admet-628	378	26	in	in	ADP
admet-628	378	27	an	an	DET
admet-628	378	28	enzymatic	enzymatic	ADJ
admet-628	378	29	assay	assay	NOUN
admet-628	378	30	to	to	ADP
admet-628	378	31	0.6	0.6	NUM
admet-628	378	32	-	-	SYM
admet-628	378	33	155	155	NUM
admet-628	378	34	nm	nm	NOUN
admet-628	378	35	(	(	PUNCT
admet-628	378	36	0.17	0.17	NUM
admet-628	378	37	-	-	SYM
admet-628	378	38	32.8	32.8	NUM
admet-628	378	39	ng	ng	PROPN
admet-628	378	40	/	/	SYM
admet-628	378	41	ml	ml	NOUN
admet-628	378	42	)	)	PUNCT
admet-628	378	43	in	in	ADP
admet-628	378	44	a	a	DET
admet-628	378	45	viral	viral	ADJ
admet-628	378	46	replication	replication	NOUN
admet-628	378	47	inhibition	inhibition	NOUN
admet-628	378	48	assay	assay	VERB
admet-628	378	49	.	.	PUNCT
admet-628	379	1	as	as	SCONJ
admet-628	379	2	such	such	DET
admet-628	379	3	the	the	DET
admet-628	379	4	ic50	ic50	PROPN
admet-628	379	5	of	of	ADP
admet-628	379	6	oc	oc	PROPN
admet-628	379	7	differs	differ	NOUN
admet-628	379	8	among	among	ADP
admet-628	379	9	the	the	DET
admet-628	379	10	subtype	subtype	NOUN
admet-628	379	11	of	of	ADP
admet-628	379	12	influenza	influenza	NOUN
admet-628	379	13	virus	virus	NOUN
admet-628	379	14	neuraminidases	neuraminidase	NOUN
admet-628	379	15	;	;	PUNCT
admet-628	379	16	it	it	PRON
admet-628	379	17	may	may	AUX
admet-628	379	18	range	range	VERB
admet-628	379	19	from	from	ADP
admet-628	379	20	0.01	0.01	NUM
admet-628	379	21	-	-	SYM
admet-628	379	22	3.3	3.3	NUM
admet-628	379	23	nm	nm	NOUN
admet-628	379	24	and	and	CCONJ
admet-628	379	25	0.72.2	0.72.2	NUM
admet-628	379	26	nm	nm	NOUN
admet-628	379	27	for	for	ADP
admet-628	379	28	h2n3	h2n3	NUM
admet-628	379	29	and	and	CCONJ
admet-628	379	30	h1n1	h1n1	NOUN
admet-628	379	31	influenza	influenza	NOUN
admet-628	379	32	viruses	virus	NOUN
admet-628	379	33	,	,	PUNCT
admet-628	379	34	respectively	respectively	ADV
admet-628	379	35	[	[	X
admet-628	379	36	32	32	NUM
admet-628	379	37	]	]	PUNCT
admet-628	379	38	.	.	PUNCT
admet-628	380	1	as	as	SCONJ
admet-628	380	2	shown	show	VERB
admet-628	380	3	in	in	ADP
admet-628	380	4	fig	fig	NOUN
admet-628	380	5	.	.	PUNCT
admet-628	381	1	9	9	NUM
admet-628	381	2	,	,	PUNCT
admet-628	381	3	the	the	DET
admet-628	381	4	steady	steady	ADJ
admet-628	381	5	-	-	PUNCT
admet-628	381	6	state	state	NOUN
admet-628	381	7	concentrations	concentration	NOUN
admet-628	381	8	of	of	ADP
admet-628	381	9	oc	oc	NOUN
admet-628	381	10	in	in	ADP
admet-628	381	11	the	the	DET
admet-628	381	12	plasma	plasma	NOUN
admet-628	381	13	/	/	SYM
admet-628	381	14	organs	organ	NOUN
admet-628	381	15	of	of	ADP
admet-628	381	16	a	a	DET
admet-628	381	17	hypothetical	hypothetical	ADJ
admet-628	381	18	human	human	NOUN
admet-628	381	19	receiving	receive	VERB
admet-628	381	20	the	the	DET
admet-628	381	21	recommended	recommend	VERB
admet-628	381	22	op	op	NOUN
admet-628	381	23	dose	dose	NOUN
admet-628	381	24	regimen	regiman	NOUN
admet-628	381	25	are	be	AUX
admet-628	381	26	much	much	ADV
admet-628	381	27	higher	high	ADJ
admet-628	381	28	than	than	ADP
admet-628	381	29	the	the	DET
admet-628	381	30	minimum	minimum	NOUN
admet-628	381	31	of	of	ADP
admet-628	381	32	in	in	ADP
admet-628	381	33	vitro	vitro	X
admet-628	381	34	ic50	ic50	PROPN
admet-628	381	35	of	of	ADP
admet-628	381	36	h1n1	h1n1	PROPN
admet-628	381	37	virus	virus	NOUN
admet-628	381	38	neuraminidase	neuraminidase	NOUN
admet-628	381	39	(	(	PUNCT
admet-628	381	40	3	3	NUM
admet-628	381	41	-	-	SYM
admet-628	381	42	10	10	NUM
admet-628	381	43	ng	ng	PROPN
admet-628	381	44	/	/	SYM
admet-628	381	45	ml	ml	NOUN
admet-628	381	46	)	)	PUNCT
admet-628	382	1	[	[	X
admet-628	382	2	14	14	NUM
admet-628	382	3	]	]	PUNCT
admet-628	382	4	.	.	PUNCT
admet-628	383	1	also	also	ADV
admet-628	383	2	,	,	PUNCT
admet-628	383	3	the	the	DET
admet-628	383	4	trough	trough	NOUN
admet-628	383	5	(	(	PUNCT
admet-628	383	6	cmin	cmin	NOUN
admet-628	383	7	)	)	PUNCT
admet-628	383	8	of	of	ADP
admet-628	383	9	the	the	DET
admet-628	383	10	oc	oc	NOUN
admet-628	383	11	concentration	concentration	NOUN
admet-628	383	12	-	-	PUNCT
admet-628	383	13	time	time	NOUN
admet-628	383	14	curve	curve	NOUN
admet-628	383	15	in	in	ADP
admet-628	383	16	the	the	DET
admet-628	383	17	lung	lung	NOUN
admet-628	383	18	is	be	AUX
admet-628	383	19	more	more	ADJ
admet-628	383	20	than	than	ADP
admet-628	383	21	10	10	NUM
admet-628	383	22	fold	fold	ADV
admet-628	383	23	higher	high	ADJ
admet-628	383	24	than	than	ADP
admet-628	383	25	the	the	DET
admet-628	383	26	ic50	ic50	PROPN
admet-628	383	27	value	value	NOUN
admet-628	383	28	(	(	PUNCT
admet-628	383	29	fig	fig	NOUN
admet-628	383	30	.	.	PUNCT
admet-628	384	1	9	9	NUM
admet-628	384	2	)	)	PUNCT
admet-628	384	3	.	.	PUNCT
admet-628	385	1	as	as	ADP
admet-628	385	2	such	such	ADJ
admet-628	385	3	,	,	PUNCT
admet-628	385	4	op	op	NOUN
admet-628	385	5	is	be	AUX
admet-628	385	6	an	an	DET
admet-628	385	7	effective	effective	ADJ
admet-628	385	8	anti	anti	ADJ
admet-628	385	9	-	-	ADJ
admet-628	385	10	viral	viral	ADJ
admet-628	385	11	drug	drug	NOUN
admet-628	385	12	for	for	ADP
admet-628	385	13	h1n1	h1n1	NOUN
admet-628	385	14	virus	virus	NOUN
admet-628	385	15	and	and	CCONJ
admet-628	385	16	perhaps	perhaps	ADV
admet-628	385	17	,	,	PUNCT
admet-628	385	18	for	for	ADP
admet-628	385	19	other	other	ADJ
admet-628	385	20	influenza	influenza	NOUN
admet-628	385	21	virus	virus	NOUN
admet-628	385	22	strains	strain	VERB
admet-628	385	23	as	as	ADV
admet-628	385	24	well	well	ADV
admet-628	385	25	[	[	X
admet-628	385	26	32	32	NUM
admet-628	385	27	]	]	PUNCT
admet-628	385	28	.	.	PUNCT
admet-628	386	1	the	the	DET
admet-628	386	2	dosimetry	dosimetry	NOUN
admet-628	386	3	of	of	ADP
admet-628	386	4	oc	oc	NOUN
admet-628	386	5	in	in	ADP
admet-628	386	6	the	the	DET
admet-628	386	7	lung	lung	NOUN
admet-628	386	8	also	also	ADV
admet-628	386	9	explains	explain	VERB
admet-628	386	10	why	why	SCONJ
admet-628	386	11	a	a	DET
admet-628	386	12	dose	dose	NOUN
admet-628	386	13	regimen	regiman	NOUN
admet-628	386	14	higher	high	ADJ
admet-628	386	15	than	than	ADP
admet-628	386	16	75	75	NUM
admet-628	386	17	mg	mg	NOUN
admet-628	386	18	op	op	NOUN
admet-628	386	19	b.i.d	b.i.d	PROPN
admet-628	386	20	.	.	PUNCT
admet-628	387	1	for	for	ADP
admet-628	387	2	one	one	NUM
admet-628	387	3	week	week	NOUN
admet-628	387	4	would	would	AUX
admet-628	387	5	not	not	PART
admet-628	387	6	increase	increase	VERB
admet-628	387	7	the	the	DET
admet-628	387	8	efficacy	efficacy	NOUN
admet-628	387	9	of	of	ADP
admet-628	387	10	op	op	NOUN
admet-628	387	11	significantly	significantly	ADV
admet-628	387	12	[	[	X
admet-628	387	13	3	3	NUM
admet-628	387	14	,	,	PUNCT
admet-628	387	15	4	4	NUM
admet-628	387	16	]	]	PUNCT
admet-628	387	17	.	.	PUNCT
admet-628	388	1	as	as	SCONJ
admet-628	388	2	shown	show	VERB
admet-628	388	3	above	above	ADV
admet-628	388	4	,	,	PUNCT
admet-628	388	5	pulmonary	pulmonary	ADJ
admet-628	388	6	oc	oc	ADP
admet-628	388	7	concentration	concentration	NOUN
admet-628	388	8	already	already	ADV
admet-628	388	9	is	be	AUX
admet-628	388	10	much	much	ADV
admet-628	388	11	higher	high	ADJ
admet-628	388	12	than	than	ADP
admet-628	388	13	the	the	DET
admet-628	388	14	minimum	minimum	NOUN
admet-628	388	15	of	of	ADP
admet-628	388	16	in	in	ADP
admet-628	388	17	vitro	vitro	X
admet-628	388	18	ic50	ic50	PROPN
admet-628	388	19	.	.	PUNCT
admet-628	389	1	thus	thus	ADV
admet-628	389	2	,	,	PUNCT
admet-628	389	3	a	a	DET
admet-628	389	4	dose	dose	NOUN
admet-628	389	5	regimen	regiman	NOUN
admet-628	389	6	higher	high	ADJ
admet-628	389	7	than	than	ADP
admet-628	389	8	75	75	NUM
admet-628	389	9	mg	mg	NOUN
admet-628	389	10	op	op	NOUN
admet-628	389	11	b.i.d	b.i.d	PROPN
admet-628	389	12	.	.	PUNCT
admet-628	389	13	is	be	AUX
admet-628	389	14	unlikely	unlikely	ADJ
admet-628	389	15	to	to	PART
admet-628	389	16	have	have	VERB
admet-628	389	17	additional	additional	ADJ
admet-628	389	18	inhibitory	inhibitory	ADJ
admet-628	389	19	effects	effect	NOUN
admet-628	389	20	on	on	ADP
admet-628	389	21	neuraminidase	neuraminidase	NOUN
admet-628	389	22	activity	activity	NOUN
admet-628	389	23	.	.	PUNCT
admet-628	390	1	the	the	DET
admet-628	390	2	side	side	NOUN
admet-628	390	3	effects	effect	NOUN
admet-628	390	4	of	of	ADP
admet-628	390	5	op	op	NOUN
admet-628	390	6	/	/	SYM
admet-628	390	7	oc	oc	NOUN
admet-628	390	8	also	also	ADV
admet-628	390	9	are	be	AUX
admet-628	390	10	explainable	explainable	ADJ
admet-628	390	11	by	by	ADP
admet-628	390	12	the	the	DET
admet-628	390	13	dose	dose	NOUN
admet-628	390	14	metrics	metric	NOUN
admet-628	390	15	of	of	ADP
admet-628	390	16	op	op	NOUN
admet-628	390	17	and	and	CCONJ
admet-628	390	18	oc	oc	NOUN
admet-628	390	19	in	in	ADP
admet-628	390	20	the	the	DET
admet-628	390	21	brain	brain	NOUN
admet-628	390	22	and	and	CCONJ
admet-628	390	23	gastrointestinal	gastrointestinal	ADJ
admet-628	390	24	tract	tract	NOUN
admet-628	390	25	;	;	PUNCT
admet-628	390	26	no	no	DET
admet-628	390	27	threshold	threshold	NOUN
admet-628	390	28	doses	dose	NOUN
admet-628	390	29	of	of	ADP
admet-628	390	30	toxicity	toxicity	NOUN
admet-628	390	31	have	have	AUX
admet-628	390	32	been	be	AUX
admet-628	390	33	reported	report	VERB
admet-628	390	34	in	in	ADP
admet-628	390	35	these	these	DET
admet-628	390	36	organs	organ	NOUN
admet-628	390	37	.	.	PUNCT
admet-628	391	1	as	as	SCONJ
admet-628	391	2	shown	show	VERB
admet-628	391	3	in	in	ADP
admet-628	391	4	fig	fig	NOUN
admet-628	391	5	.	.	PUNCT
admet-628	392	1	8	8	NUM
admet-628	392	2	,	,	PUNCT
admet-628	392	3	modeled	model	VERB
admet-628	392	4	oc	oc	ADP
admet-628	392	5	aucbrain	aucbrain	NOUN
admet-628	392	6	/	/	SYM
admet-628	392	7	aucplasma	aucplasma	ADJ
admet-628	392	8	ratios	ratio	NOUN
admet-628	392	9	for	for	ADP
admet-628	392	10	humans	human	NOUN
admet-628	392	11	dosed	dose	VERB
admet-628	392	12	with	with	ADP
admet-628	392	13	50	50	NUM
admet-628	392	14	,	,	PUNCT
admet-628	392	15	100	100	NUM
admet-628	392	16	,	,	PUNCT
admet-628	392	17	200	200	NUM
admet-628	392	18	,	,	PUNCT
admet-628	392	19	and	and	CCONJ
admet-628	392	20	500	500	NUM
admet-628	392	21	mg	mg	NOUN
admet-628	392	22	op	op	NOUN
admet-628	392	23	are	be	AUX
admet-628	392	24	5.34/21.4	5.34/21.4	NUM
admet-628	392	25	,	,	PUNCT
admet-628	392	26	10.6/42.5	10.6/42.5	NOUN
admet-628	392	27	,	,	PUNCT
admet-628	392	28	21.3/85.3	21.3/85.3	NUM
admet-628	392	29	,	,	PUNCT
admet-628	392	30	and	and	CCONJ
admet-628	392	31	52.5/210.2	52.5/210.2	NUM
admet-628	392	32	,	,	PUNCT
admet-628	392	33	respectively	respectively	ADV
admet-628	392	34	,	,	PUNCT
admet-628	392	35	(	(	PUNCT
admet-628	392	36	fig.8	fig.8	PROPN
admet-628	392	37	)	)	PUNCT
admet-628	392	38	yielding	yield	VERB
admet-628	392	39	a	a	DET
admet-628	392	40	mean	mean	NOUN
admet-628	392	41	oc	oc	ADP
admet-628	392	42	aucbrain	aucbrain	NOUN
admet-628	392	43	/	/	SYM
admet-628	392	44	aucplasma	aucplasma	PROPN
admet-628	392	45	ratio	ratio	NOUN
admet-628	392	46	of	of	ADP
admet-628	392	47	about	about	ADV
admet-628	392	48	0.25	0.25	NUM
admet-628	392	49	.	.	PUNCT
admet-628	393	1	jhee	jhee	PROPN
admet-628	393	2	et	et	PROPN
admet-628	394	1	al	al	PROPN
admet-628	395	1	[	[	X
admet-628	395	2	42	42	NUM
admet-628	395	3	]	]	PUNCT
admet-628	395	4	have	have	AUX
admet-628	395	5	reported	report	VERB
admet-628	395	6	that	that	SCONJ
admet-628	395	7	the	the	DET
admet-628	395	8	mean	mean	ADJ
admet-628	395	9	spinal	spinal	ADJ
admet-628	395	10	fluid	fluid	NOUN
admet-628	395	11	/	/	SYM
admet-628	395	12	plasma	plasma	NOUN
admet-628	395	13	concentration	concentration	NOUN
admet-628	395	14	ratio	ratio	NOUN
admet-628	395	15	for	for	ADP
admet-628	395	16	oc	oc	NOUN
admet-628	395	17	in	in	ADP
admet-628	395	18	humans	human	NOUN
admet-628	395	19	is	be	AUX
admet-628	395	20	2.93	2.93	NUM
admet-628	395	21	+	+	NUM
admet-628	395	22	4.06	4.06	NUM
admet-628	395	23	which	which	PRON
admet-628	395	24	is	be	AUX
admet-628	395	25	about	about	ADV
admet-628	395	26	10	10	NUM
admet-628	395	27	-	-	ADJ
admet-628	395	28	fold	fold	VERB
admet-628	395	29	higher	high	ADJ
admet-628	395	30	than	than	ADP
admet-628	395	31	the	the	DET
admet-628	395	32	modeled	model	VERB
admet-628	395	33	aucbrain	aucbrain	NOUN
admet-628	395	34	/	/	SYM
admet-628	395	35	aucplasma	aucplasma	PROPN
admet-628	395	36	ratio	ratio	NOUN
admet-628	395	37	observed	observe	VERB
admet-628	395	38	in	in	ADP
admet-628	395	39	the	the	DET
admet-628	395	40	present	present	ADJ
admet-628	395	41	study	study	NOUN
admet-628	395	42	.	.	PUNCT
admet-628	396	1	other	other	ADJ
admet-628	396	2	study	study	NOUN
admet-628	396	3	reported	report	VERB
admet-628	396	4	the	the	DET
admet-628	396	5	brain	brain	NOUN
admet-628	396	6	-	-	PUNCT
admet-628	396	7	to	to	ADP
admet-628	396	8	-	-	PUNCT
admet-628	396	9	plasma	plasma	NOUN
admet-628	396	10	exposure	exposure	NOUN
admet-628	396	11	ratios	ratio	NOUN
admet-628	396	12	approximately	approximately	ADV
admet-628	396	13	0.2	0.2	NUM
admet-628	396	14	for	for	ADP
admet-628	396	15	op	op	NOUN
admet-628	396	16	and	and	CCONJ
admet-628	396	17	0.01	0.01	NUM
admet-628	396	18	for	for	ADP
admet-628	396	19	oc	oc	NOUN
admet-628	396	20	[	[	X
admet-628	396	21	43	43	NUM
admet-628	396	22	,	,	PUNCT
admet-628	396	23	44	44	NUM
admet-628	396	24	]	]	PUNCT
admet-628	396	25	,	,	PUNCT
admet-628	396	26	these	these	DET
admet-628	396	27	result	result	NOUN
admet-628	396	28	suggested	suggest	VERB
admet-628	396	29	significant	significant	ADJ
admet-628	396	30	variation	variation	NOUN
admet-628	396	31	between	between	ADP
admet-628	396	32	different	different	ADJ
admet-628	396	33	studies	study	NOUN
admet-628	396	34	.	.	PUNCT
admet-628	397	1	in	in	ADP
admet-628	397	2	our	our	PRON
admet-628	397	3	model	model	NOUN
admet-628	397	4	,	,	PUNCT
admet-628	397	5	the	the	DET
admet-628	397	6	brain/	brain/	NUM
admet-628	397	7	plasma	plasma	NOUN
admet-628	397	8	partition	partition	NOUN
admet-628	397	9	coefficients	coefficient	NOUN
admet-628	397	10	for	for	ADP
admet-628	397	11	op	op	NOUN
admet-628	397	12	and	and	CCONJ
admet-628	397	13	oc	oc	NOUN
admet-628	397	14	were	be	AUX
admet-628	397	15	0.5	0.5	NUM
admet-628	397	16	and	and	CCONJ
admet-628	397	17	0.25	0.25	NUM
admet-628	397	18	respectively	respectively	ADV
admet-628	397	19	.	.	PUNCT
admet-628	398	1	it	it	PRON
admet-628	398	2	is	be	AUX
admet-628	398	3	assumed	assume	VERB
admet-628	398	4	that	that	SCONJ
admet-628	398	5	only	only	ADV
admet-628	398	6	a	a	DET
admet-628	398	7	small	small	ADJ
admet-628	398	8	amount	amount	NOUN
admet-628	398	9	of	of	ADP
admet-628	398	10	oc	oc	NOUN
admet-628	398	11	seems	seem	VERB
admet-628	398	12	able	able	ADJ
admet-628	398	13	to	to	PART
admet-628	398	14	penetrate	penetrate	VERB
admet-628	398	15	the	the	DET
admet-628	398	16	blood	blood	NOUN
admet-628	398	17	-	-	PUNCT
admet-628	398	18	brain	brain	NOUN
admet-628	398	19	barrier	barrier	NOUN
admet-628	398	20	to	to	PART
admet-628	398	21	reach	reach	VERB
admet-628	398	22	the	the	DET
admet-628	398	23	brain	brain	NOUN
admet-628	398	24	tissue	tissue	NOUN
admet-628	398	25	considering	consider	VERB
admet-628	398	26	oc	oc	X
admet-628	398	27	with	with	ADP
admet-628	398	28	high	high	ADJ
admet-628	398	29	polarity	polarity	NOUN
admet-628	398	30	and	and	CCONJ
admet-628	398	31	op	op	NOUN
admet-628	398	32	as	as	ADP
admet-628	398	33	the	the	DET
admet-628	398	34	substrate	substrate	NOUN
admet-628	398	35	of	of	ADP
admet-628	398	36	efflux	efflux	ADJ
admet-628	398	37	transporter	transporter	NOUN
admet-628	398	38	-	-	PUNCT
admet-628	398	39	p	p	NOUN
admet-628	398	40	-	-	PUNCT
admet-628	398	41	glycoprotein	glycoprotein	NOUN
admet-628	398	42	.	.	PUNCT
admet-628	399	1	as	as	SCONJ
admet-628	399	2	such	such	ADJ
admet-628	399	3	,	,	PUNCT
admet-628	399	4	op	op	NOUN
admet-628	399	5	/	/	SYM
admet-628	399	6	oc	oc	NOUN
admet-628	399	7	probably	probably	ADV
admet-628	399	8	is	be	AUX
admet-628	399	9	not	not	PART
admet-628	399	10	the	the	DET
admet-628	399	11	major	major	ADJ
admet-628	399	12	cause	cause	NOUN
admet-628	399	13	of	of	ADP
admet-628	399	14	the	the	DET
admet-628	399	15	observed	observe	VERB
admet-628	399	16	neuropsychiatric	neuropsychiatric	ADJ
admet-628	399	17	effects	effect	NOUN
admet-628	399	18	in	in	ADP
admet-628	399	19	humans	human	NOUN
admet-628	399	20	.	.	PUNCT
admet-628	400	1	as	as	ADP
admet-628	400	2	for	for	ADP
admet-628	400	3	the	the	DET
admet-628	400	4	gastrointestinal	gastrointestinal	ADJ
admet-628	400	5	side	side	NOUN
admet-628	400	6	effects	effect	NOUN
admet-628	400	7	(	(	PUNCT
admet-628	400	8	e.g.	e.g.	ADV
admet-628	400	9	,	,	PUNCT
admet-628	400	10	abdominal	abdominal	ADJ
admet-628	400	11	pain	pain	NOUN
admet-628	400	12	,	,	PUNCT
admet-628	400	13	diarrhea	diarrhea	NOUN
admet-628	400	14	,	,	PUNCT
admet-628	400	15	and	and	CCONJ
admet-628	400	16	nausea	nausea	NOUN
admet-628	400	17	)	)	PUNCT
admet-628	401	1	[	[	X
admet-628	401	2	3,4	3,4	NUM
admet-628	401	3	]	]	PUNCT
admet-628	401	4	,	,	PUNCT
admet-628	401	5	they	they	PRON
admet-628	401	6	may	may	AUX
admet-628	401	7	be	be	AUX
admet-628	401	8	related	relate	VERB
admet-628	401	9	to	to	ADP
admet-628	401	10	the	the	DET
admet-628	401	11	high	high	ADJ
admet-628	401	12	levels	level	NOUN
admet-628	401	13	of	of	ADP
admet-628	401	14	op	op	NOUN
admet-628	401	15	in	in	ADP
admet-628	401	16	the	the	DET
admet-628	401	17	digestive	digestive	ADJ
admet-628	401	18	system	system	NOUN
admet-628	401	19	and	and	CCONJ
admet-628	401	20	contact	contact	NOUN
admet-628	401	21	site	site	NOUN
admet-628	401	22	toxicity	toxicity	NOUN
admet-628	401	23	since	since	SCONJ
admet-628	401	24	op	op	NOUN
admet-628	401	25	concentrations	concentration	NOUN
admet-628	401	26	in	in	ADP
admet-628	401	27	the	the	DET
admet-628	401	28	gastrointestinal	gastrointestinal	ADJ
admet-628	401	29	tract	tract	NOUN
admet-628	401	30	and	and	CCONJ
admet-628	401	31	liver	liver	NOUN
admet-628	401	32	may	may	AUX
admet-628	401	33	be	be	AUX
admet-628	401	34	as	as	ADV
admet-628	401	35	high	high	ADJ
admet-628	401	36	as	as	ADP
admet-628	401	37	3.72	3.72	NUM
admet-628	401	38	µg	µg	NOUN
admet-628	401	39	/	/	SYM
admet-628	401	40	g	g	NOUN
admet-628	401	41	and	and	CCONJ
admet-628	401	42	2.00	2.00	NUM
admet-628	401	43	µg	µg	ADJ
admet-628	401	44	/	/	SYM
admet-628	401	45	g	g	NOUN
admet-628	401	46	,	,	PUNCT
admet-628	401	47	respectively	respectively	ADV
admet-628	401	48	(	(	PUNCT
admet-628	401	49	fig	fig	NOUN
admet-628	401	50	.	.	PUNCT
admet-628	402	1	8)	8)	NUM
admet-628	402	2	.	.	PUNCT
admet-628	403	1	this	this	PRON
admet-628	403	2	is	be	AUX
admet-628	403	3	the	the	DET
admet-628	403	4	first	first	ADJ
admet-628	403	5	study	study	NOUN
admet-628	403	6	in	in	ADP
admet-628	403	7	which	which	PRON
admet-628	403	8	a	a	DET
admet-628	403	9	pbpk	pbpk	ADJ
admet-628	403	10	model	model	NOUN
admet-628	403	11	is	be	AUX
admet-628	403	12	used	use	VERB
admet-628	403	13	to	to	PART
admet-628	403	14	predict	predict	VERB
admet-628	403	15	the	the	DET
admet-628	403	16	internal	internal	ADJ
admet-628	403	17	tissue	tissue	NOUN
admet-628	403	18	doses	dose	NOUN
admet-628	403	19	of	of	ADP
admet-628	403	20	op	op	NOUN
admet-628	403	21	/	/	SYM
admet-628	403	22	oc	oc	NOUN
admet-628	403	23	in	in	ADP
admet-628	403	24	humans	human	NOUN
admet-628	403	25	.	.	PUNCT
admet-628	404	1	the	the	DET
admet-628	404	2	human	human	ADJ
admet-628	404	3	and	and	CCONJ
admet-628	404	4	rat	rat	NOUN
admet-628	404	5	pbpk	pbpk	NOUN
admet-628	404	6	models	model	NOUN
admet-628	404	7	are	be	AUX
admet-628	404	8	able	able	ADJ
admet-628	404	9	to	to	PART
admet-628	404	10	predict	predict	VERB
admet-628	404	11	the	the	DET
admet-628	404	12	pharmacokinetic	pharmacokinetic	ADJ
admet-628	404	13	behaviors	behavior	NOUN
admet-628	404	14	and	and	CCONJ
admet-628	404	15	internal	internal	ADJ
admet-628	404	16	tissue	tissue	NOUN
admet-628	404	17	doses	dose	NOUN
admet-628	404	18	of	of	ADP
admet-628	404	19	op	op	NOUN
admet-628	404	20	and	and	CCONJ
admet-628	404	21	oc	oc	VERB
admet-628	404	22	accurately	accurately	ADV
admet-628	404	23	.	.	PUNCT
admet-628	405	1	thus	thus	ADV
admet-628	405	2	,	,	PUNCT
admet-628	405	3	the	the	DET
admet-628	405	4	pbpk	pbpk	ADJ
admet-628	405	5	model	model	NOUN
admet-628	405	6	is	be	AUX
admet-628	405	7	a	a	DET
admet-628	405	8	valuable	valuable	ADJ
admet-628	405	9	,	,	PUNCT
admet-628	405	10	quantitative	quantitative	ADJ
admet-628	405	11	tool	tool	NOUN
admet-628	405	12	for	for	ADP
admet-628	405	13	routerelated	routerelated	ADJ
admet-628	405	14	(	(	PUNCT
admet-628	405	15	fig	fig	NOUN
admet-628	405	16	.	.	PUNCT
admet-628	406	1	5	5	NUM
admet-628	406	2	)	)	PUNCT
admet-628	406	3	,	,	PUNCT
admet-628	406	4	species	specie	NOUN
admet-628	406	5	-	-	PUNCT
admet-628	406	6	related	relate	VERB
admet-628	406	7	(	(	PUNCT
admet-628	406	8	fig	fig	NOUN
admet-628	406	9	.	.	PUNCT
admet-628	407	1	6	6	NUM
admet-628	407	2	)	)	PUNCT
admet-628	407	3	,	,	PUNCT
admet-628	407	4	and	and	CCONJ
admet-628	407	5	dose	dose	NOUN
admet-628	407	6	-	-	PUNCT
admet-628	407	7	related	relate	VERB
admet-628	407	8	(	(	PUNCT
admet-628	407	9	fig	fig	NOUN
admet-628	407	10	.	.	PUNCT
admet-628	408	1	8)	8)	NUM
admet-628	408	2	extrapolation	extrapolation	NOUN
admet-628	408	3	.	.	PUNCT
admet-628	409	1	the	the	DET
admet-628	409	2	proposed	propose	VERB
admet-628	409	3	pbpk	pbpk	NOUN
admet-628	409	4	model	model	NOUN
admet-628	409	5	has	have	VERB
admet-628	409	6	many	many	ADJ
admet-628	409	7	practical	practical	ADJ
admet-628	409	8	applications	application	NOUN
admet-628	409	9	:	:	PUNCT
admet-628	409	10	it	it	PRON
admet-628	409	11	can	can	AUX
admet-628	409	12	be	be	AUX
admet-628	409	13	used	use	VERB
admet-628	409	14	to	to	PART
admet-628	409	15	assess	assess	VERB
admet-628	409	16	the	the	DET
admet-628	409	17	dosimetry	dosimetry	NOUN
admet-628	409	18	of	of	ADP
admet-628	409	19	op	op	NOUN
admet-628	409	20	/	/	SYM
admet-628	409	21	oc	oc	NOUN
admet-628	409	22	in	in	ADP
admet-628	409	23	the	the	DET
admet-628	409	24	internal	internal	ADJ
admet-628	409	25	tissues	tissue	NOUN
admet-628	409	26	/	/	SYM
admet-628	409	27	organs	organ	NOUN
admet-628	409	28	of	of	ADP
admet-628	409	29	humans	human	NOUN
admet-628	409	30	providing	provide	VERB
admet-628	409	31	a	a	DET
admet-628	409	32	more	more	ADV
admet-628	409	33	realistic	realistic	ADJ
admet-628	409	34	and	and	CCONJ
admet-628	409	35	accurate	accurate	ADJ
admet-628	409	36	account	account	NOUN
admet-628	409	37	of	of	ADP
admet-628	409	38	the	the	DET
admet-628	409	39	dose	dose	NOUN
admet-628	409	40	-	-	PUNCT
admet-628	409	41	response	response	NOUN
admet-628	409	42	g.	g.	PROPN
admet-628	409	43	gao	gao	PROPN
admet-628	409	44	et	et	PROPN
admet-628	409	45	al	al	PROPN
admet-628	409	46	.	.	PROPN
admet-628	409	47	admet	admet	PROPN
admet-628	409	48	&	&	CCONJ
admet-628	409	49	dmpk	dmpk	PROPN
admet-628	409	50	7(1	7(1	PROPN
admet-628	409	51	)	)	PUNCT
admet-628	409	52	(	(	PUNCT
admet-628	409	53	2019	2019	NUM
admet-628	409	54	)	)	PUNCT
admet-628	409	55	22	22	NUM
admet-628	409	56	-	-	SYM
admet-628	409	57	43	43	NUM
admet-628	409	58	38	38	NUM
admet-628	409	59	relationship	relationship	NOUN
admet-628	409	60	of	of	ADP
admet-628	409	61	op	op	NOUN
admet-628	409	62	/	/	SYM
admet-628	409	63	oc	oc	NOUN
admet-628	409	64	than	than	ADP
admet-628	409	65	the	the	DET
admet-628	409	66	externally	externally	ADV
admet-628	409	67	applied	apply	VERB
admet-628	409	68	dose	dose	NOUN
admet-628	409	69	.	.	PUNCT
admet-628	410	1	the	the	DET
admet-628	410	2	pbpk	pbpk	PROPN
admet-628	410	3	model	model	NOUN
admet-628	410	4	also	also	ADV
admet-628	410	5	is	be	AUX
admet-628	410	6	useful	useful	ADJ
admet-628	410	7	in	in	ADP
admet-628	410	8	adjusting	adjust	VERB
admet-628	410	9	the	the	DET
admet-628	410	10	dose	dose	NOUN
admet-628	410	11	regimens	regimen	NOUN
admet-628	410	12	for	for	ADP
admet-628	410	13	patients	patient	NOUN
admet-628	410	14	in	in	ADP
admet-628	410	15	disease	disease	NOUN
admet-628	410	16	states	state	NOUN
admet-628	410	17	such	such	ADJ
admet-628	410	18	as	as	ADP
admet-628	410	19	renal	renal	ADJ
admet-628	410	20	failure	failure	NOUN
admet-628	410	21	and	and	CCONJ
admet-628	410	22	liver	liver	NOUN
admet-628	410	23	damage	damage	NOUN
admet-628	410	24	[	[	X
admet-628	410	25	22	22	NUM
admet-628	410	26	]	]	PUNCT
admet-628	410	27	.	.	PUNCT
admet-628	411	1	conflict	conflict	NOUN
admet-628	411	2	of	of	ADP
admet-628	411	3	interest	interest	NOUN
admet-628	411	4	statement	statement	NOUN
admet-628	411	5	:	:	PUNCT
admet-628	411	6	there	there	PRON
admet-628	411	7	is	be	VERB
admet-628	411	8	no	no	DET
admet-628	411	9	conflict	conflict	NOUN
admet-628	411	10	of	of	ADP
admet-628	411	11	interest	interest	NOUN
admet-628	411	12	for	for	ADP
admet-628	411	13	this	this	DET
admet-628	411	14	study	study	NOUN
admet-628	411	15	.	.	PUNCT
admet-628	412	1	list	list	NOUN
admet-628	412	2	of	of	ADP
admet-628	412	3	abbreviations	abbreviation	NOUN
admet-628	412	4	pbpk	pbpk	NOUN
admet-628	412	5	model	model	NOUN
admet-628	412	6	:	:	PUNCT
admet-628	412	7	physiologically	physiologically	ADV
admet-628	412	8	-	-	PUNCT
admet-628	412	9	based	base	VERB
admet-628	412	10	pharmacokinetic	pharmacokinetic	ADJ
admet-628	412	11	model	model	NOUN
admet-628	412	12	;	;	PUNCT
admet-628	412	13	op	op	NOUN
admet-628	412	14	:	:	PUNCT
admet-628	412	15	oseltamivir	oseltamivir	PROPN
admet-628	412	16	phosphate	phosphate	VERB
admet-628	412	17	;	;	PUNCT
admet-628	412	18	oc	oc	ADP
admet-628	412	19	:	:	PUNCT
admet-628	412	20	oseltamivir	oseltamivir	PROPN
admet-628	412	21	carboxylate	carboxylate	PROPN
admet-628	412	22	;	;	PUNCT
admet-628	413	1	f	f	X
admet-628	413	2	:	:	PUNCT
admet-628	413	3	fraction	fraction	NOUN
admet-628	413	4	of	of	ADP
admet-628	413	5	absorption	absorption	NOUN
admet-628	413	6	or	or	CCONJ
admet-628	413	7	empirical	empirical	ADJ
admet-628	413	8	bioavailability	bioavailability	NOUN
admet-628	413	9	factor	factor	NOUN
admet-628	413	10	ka	ka	NOUN
admet-628	413	11	:	:	PUNCT
admet-628	413	12	absorption	absorption	NOUN
admet-628	413	13	rate	rate	NOUN
admet-628	413	14	constant	constant	ADJ
admet-628	413	15	;	;	PUNCT
admet-628	413	16	tlag	tlag	NOUN
admet-628	413	17	:	:	PUNCT
admet-628	413	18	lag	lag	VERB
admet-628	413	19	time	time	NOUN
admet-628	413	20	for	for	ADP
admet-628	413	21	absorption	absorption	NOUN
admet-628	413	22	cl	cl	NOUN
admet-628	413	23	:	:	PUNCT
admet-628	413	24	whole	whole	ADJ
admet-628	413	25	body	body	NOUN
admet-628	413	26	clearance	clearance	NOUN
admet-628	413	27	;	;	PUNCT
admet-628	413	28	km	km	NOUN
admet-628	413	29	:	:	PUNCT
admet-628	413	30	michaelis	michaelis	PROPN
admet-628	413	31	constant	constant	PROPN
admet-628	413	32	;	;	PUNCT
admet-628	413	33	vmax	vmax	PROPN
admet-628	413	34	:	:	PUNCT
admet-628	413	35	maximum	maximum	ADJ
admet-628	413	36	reaction	reaction	NOUN
admet-628	413	37	rate	rate	NOUN
admet-628	413	38	;	;	PUNCT
admet-628	413	39	kf	kf	NOUN
admet-628	413	40	:	:	PUNCT
admet-628	413	41	the	the	DET
admet-628	413	42	fecal	fecal	ADJ
admet-628	413	43	excretion	excretion	NOUN
admet-628	413	44	rate	rate	NOUN
admet-628	413	45	constant	constant	ADJ
admet-628	413	46	qxy	qxy	NOUN
admet-628	413	47	:	:	PUNCT
admet-628	413	48	blood	blood	NOUN
admet-628	413	49	flow	flow	NOUN
admet-628	413	50	to	to	ADP
admet-628	413	51	the	the	DET
admet-628	413	52	organ	organ	NOUN
admet-628	413	53	;	;	PUNCT
admet-628	413	54	cxy	cxy	ADJ
admet-628	413	55	:	:	PUNCT
admet-628	413	56	op	op	NOUN
admet-628	413	57	/	/	SYM
admet-628	413	58	oc	oc	NOUN
admet-628	413	59	concentration	concentration	NOUN
admet-628	413	60	in	in	ADP
admet-628	413	61	the	the	DET
admet-628	413	62	organ	organ	NOUN
admet-628	413	63	;	;	PUNCT
admet-628	413	64	vxy	vxy	VERB
admet-628	413	65	:	:	PUNCT
admet-628	413	66	volume	volume	NOUN
admet-628	413	67	of	of	ADP
admet-628	413	68	the	the	DET
admet-628	413	69	organ	organ	NOUN
admet-628	413	70	;	;	PUNCT
admet-628	413	71	rxy	rxy	NUM
admet-628	413	72	:	:	PUNCT
admet-628	413	73	tissue	tissue	NOUN
admet-628	413	74	/	/	SYM
admet-628	413	75	plasma	plasma	NOUN
admet-628	413	76	partition	partition	NOUN
admet-628	413	77	coefficient	coefficient	NOUN
admet-628	413	78	for	for	ADP
admet-628	413	79	the	the	DET
admet-628	413	80	tissue	tissue	NOUN
admet-628	413	81	;	;	PUNCT
admet-628	413	82	blplr	blplr	NOUN
admet-628	413	83	:	:	PUNCT
admet-628	413	84	blood	blood	NOUN
admet-628	413	85	and	and	CCONJ
admet-628	413	86	plasma	plasma	NOUN
admet-628	413	87	concentration	concentration	NOUN
admet-628	413	88	ratio	ratio	NOUN
admet-628	413	89	for	for	ADP
admet-628	413	90	op	op	NOUN
admet-628	413	91	or	or	CCONJ
admet-628	413	92	oc	oc	ADP
admet-628	413	93	auc	auc	NOUN
admet-628	413	94	:	:	PUNCT
admet-628	413	95	area	area	NOUN
admet-628	413	96	under	under	ADP
admet-628	413	97	the	the	DET
admet-628	413	98	time	time	NOUN
admet-628	413	99	-	-	PUNCT
admet-628	413	100	concentration	concentration	NOUN
admet-628	413	101	curve	curve	NOUN
admet-628	413	102	bw	bw	NOUN
admet-628	413	103	:	:	PUNCT
admet-628	413	104	the	the	DET
admet-628	413	105	average	average	ADJ
admet-628	413	106	body	body	NOUN
admet-628	413	107	weight	weight	NOUN
admet-628	413	108	of	of	ADP
admet-628	413	109	humans	human	NOUN
admet-628	413	110	and	and	CCONJ
admet-628	413	111	rats	rat	NOUN
admet-628	413	112	.	.	PUNCT
admet-628	414	1	acknowledgements	acknowledgement	NOUN
admet-628	414	2	:	:	PUNCT
admet-628	414	3	the	the	DET
admet-628	414	4	authors	author	NOUN
admet-628	414	5	thank	thank	VERB
admet-628	414	6	the	the	DET
admet-628	414	7	rfcid	rfcid	NOUN
admet-628	414	8	/	/	SYM
admet-628	414	9	hhsrf	hhsrf	NOUN
admet-628	414	10	/	/	SYM
admet-628	414	11	hsrf	hsrf	ADJ
admet-628	414	12	/	/	SYM
admet-628	414	13	hcpf	hcpf	PROPN
admet-628	414	14	in	in	ADP
admet-628	414	15	hong	hong	PROPN
admet-628	414	16	kong	kong	PROPN
admet-628	414	17	for	for	ADP
admet-628	414	18	financial	financial	ADJ
admet-628	414	19	support	support	NOUN
admet-628	414	20	of	of	ADP
admet-628	414	21	this	this	DET
admet-628	414	22	project	project	NOUN
admet-628	414	23	,	,	PUNCT
admet-628	414	24	and	and	CCONJ
admet-628	414	25	hoffman	hoffman	PROPN
admet-628	414	26	la	la	PROPN
admet-628	414	27	-	-	PROPN
admet-628	414	28	roche	roche	NOUN
admet-628	414	29	for	for	ADP
admet-628	414	30	providing	provide	VERB
admet-628	414	31	tamiflu	tamiflu	NOUN
admet-628	414	32	(	(	PUNCT
admet-628	414	33	both	both	CCONJ
admet-628	414	34	the	the	DET
admet-628	414	35	pro	pro	ADJ
admet-628	414	36	-	-	ADJ
admet-628	414	37	drug	drug	ADJ
admet-628	414	38	oseltamivir	oseltamivir	NOUN
admet-628	414	39	phosphate	phosphate	VERB
admet-628	414	40	and	and	CCONJ
admet-628	414	41	the	the	DET
admet-628	414	42	active	active	ADJ
admet-628	414	43	metabolite	metabolite	NOUN
admet-628	414	44	oseltamivir	oseltamivir	PROPN
admet-628	414	45	carboxylate	carboxylate	PROPN
admet-628	414	46	)	)	PUNCT
admet-628	414	47	for	for	ADP
admet-628	414	48	the	the	DET
admet-628	414	49	project	project	NOUN
admet-628	414	50	.	.	PUNCT
admet-628	415	1	the	the	DET
admet-628	415	2	authors	author	NOUN
admet-628	415	3	also	also	ADV
admet-628	415	4	thank	thank	VERB
admet-628	415	5	prof	prof	PROPN
admet-628	415	6	.	.	PUNCT
admet-628	416	1	hei	hei	PROPN
admet-628	416	2	wun	wun	PROPN
admet-628	416	3	leung	leung	PROPN
admet-628	416	4	and	and	CCONJ
admet-628	416	5	the	the	DET
admet-628	416	6	cma	cma	PROPN
admet-628	416	7	laboratory	laboratory	NOUN
admet-628	416	8	for	for	ADP
admet-628	416	9	their	their	PRON
admet-628	416	10	help	help	NOUN
admet-628	416	11	in	in	ADP
admet-628	416	12	developing	develop	VERB
admet-628	416	13	analytical	analytical	ADJ
admet-628	416	14	methods	method	NOUN
admet-628	416	15	for	for	ADP
admet-628	416	16	tamiflu	tamiflu	NOUN
admet-628	416	17	and	and	CCONJ
admet-628	416	18	its	its	PRON
admet-628	416	19	metabolite	metabolite	NOUN
admet-628	416	20	,	,	PUNCT
admet-628	416	21	and	and	CCONJ
admet-628	416	22	dr	dr	PROPN
admet-628	416	23	.	.	PROPN
admet-628	416	24	j.a	j.a	PROPN
admet-628	416	25	.	.	PROPN
admet-628	416	26	raymond	raymond	PROPN
admet-628	416	27	for	for	ADP
admet-628	416	28	reviewing	review	VERB
admet-628	416	29	the	the	DET
admet-628	416	30	manuscript	manuscript	NOUN
admet-628	416	31	.	.	PUNCT
admet-628	417	1	references	reference	NOUN
admet-628	417	2	[	[	X
admet-628	417	3	1	1	NUM
admet-628	417	4	]	]	X
admet-628	417	5	j.r	j.r	PROPN
admet-628	417	6	.	.	PROPN
admet-628	417	7	smith	smith	PROPN
admet-628	417	8	,	,	PUNCT
admet-628	417	9	c.r	c.r	PROPN
admet-628	417	10	.	.	PROPN
admet-628	417	11	rayner	rayner	PROPN
admet-628	417	12	,	,	PUNCT
admet-628	417	13	b.	b.	PROPN
admet-628	417	14	donner	donner	PROPN
admet-628	417	15	,	,	PUNCT
admet-628	417	16	m.	m.	NOUN
admet-628	417	17	wollenhaupt	wollenhaupt	PROPN
admet-628	417	18	,	,	PUNCT
admet-628	417	19	k.	k.	PROPN
admet-628	417	20	klumpp	klumpp	PROPN
admet-628	417	21	,	,	PUNCT
admet-628	417	22	r.	r.	PROPN
admet-628	417	23	dutkowski	dutkowski	PROPN
admet-628	417	24	.	.	PUNCT
admet-628	418	1	oseltamivir	oseltamivir	PROPN
admet-628	418	2	in	in	ADP
admet-628	418	3	seasonal	seasonal	ADJ
admet-628	418	4	,	,	PUNCT
admet-628	418	5	pandemic	pandemic	ADJ
admet-628	418	6	,	,	PUNCT
admet-628	418	7	and	and	CCONJ
admet-628	418	8	avian	avian	ADJ
admet-628	418	9	influenza	influenza	NOUN
admet-628	418	10	:	:	PUNCT
admet-628	418	11	a	a	DET
admet-628	418	12	comprehensive	comprehensive	ADJ
admet-628	418	13	review	review	NOUN
admet-628	418	14	of	of	ADP
admet-628	418	15	10	10	NUM
admet-628	418	16	-	-	PUNCT
admet-628	418	17	years	year	NOUN
admet-628	418	18	clinical	clinical	ADJ
admet-628	418	19	experience	experience	NOUN
admet-628	418	20	.	.	PUNCT
admet-628	419	1	adv	adv	PROPN
admet-628	419	2	.	.	PUNCT
admet-628	420	1	ther	ther	PROPN
admet-628	420	2	.	.	PUNCT
admet-628	421	1	28(11	28(11	NUM
admet-628	421	2	)	)	PUNCT
admet-628	421	3	(	(	PUNCT
admet-628	421	4	2011	2011	NUM
admet-628	421	5	)	)	PUNCT
admet-628	421	6	927	927	NUM
admet-628	421	7	-	-	SYM
admet-628	421	8	959	959	NUM
admet-628	421	9	.	.	PUNCT
admet-628	422	1	[	[	X
admet-628	422	2	2	2	NUM
admet-628	422	3	]	]	X
admet-628	422	4	d.	d.	PROPN
admet-628	422	5	shi	shi	PROPN
admet-628	422	6	,	,	PUNCT
admet-628	422	7	j.	j.	PROPN
admet-628	422	8	yang	yang	PROPN
admet-628	422	9	,	,	PUNCT
admet-628	422	10	d.	d.	PROPN
admet-628	422	11	yang	yang	PROPN
admet-628	422	12	,	,	PUNCT
admet-628	422	13	e.l	e.l	PROPN
admet-628	422	14	.	.	PROPN
admet-628	422	15	lecluyse	lecluyse	PROPN
admet-628	422	16	,	,	PUNCT
admet-628	422	17	c.	c.	PROPN
admet-628	422	18	black	black	PROPN
admet-628	422	19	,	,	PUNCT
admet-628	422	20	l.you	l.you	INTJ
admet-628	422	21	,	,	PUNCT
admet-628	422	22	f.	f.	PROPN
admet-628	422	23	akhlaghi	akhlaghi	PROPN
admet-628	422	24	,	,	PUNCT
admet-628	422	25	b.yan	b.yan	NOUN
admet-628	422	26	.	.	PUNCT
admet-628	422	27	anti	anti	ADJ
admet-628	422	28	-	-	ADJ
admet-628	422	29	influenza	influenza	ADJ
admet-628	422	30	prodrug	prodrug	NOUN
admet-628	422	31	oseltamivir	oseltamivir	PROPN
admet-628	422	32	is	be	AUX
admet-628	422	33	activated	activate	VERB
admet-628	422	34	by	by	ADP
admet-628	422	35	carboxylesterase	carboxylesterase	NOUN
admet-628	422	36	human	human	ADJ
admet-628	422	37	carboxylesterase	carboxylesterase	NOUN
admet-628	422	38	1	1	NUM
admet-628	422	39	,	,	PUNCT
admet-628	422	40	and	and	CCONJ
admet-628	422	41	the	the	DET
admet-628	422	42	activation	activation	NOUN
admet-628	422	43	is	be	AUX
admet-628	422	44	inhibited	inhibit	VERB
admet-628	422	45	by	by	ADP
admet-628	422	46	antiplatelet	antiplatelet	ADJ
admet-628	422	47	agent	agent	NOUN
admet-628	422	48	clopidogrel	clopidogrel	NOUN
admet-628	422	49	.	.	PUNCT
admet-628	423	1	j.	j.	PROPN
admet-628	423	2	pharmacol	pharmacol	PROPN
admet-628	423	3	.	.	PUNCT
admet-628	424	1	exp	exp	PROPN
admet-628	424	2	.	.	PUNCT
admet-628	425	1	ther	ther	PROPN
admet-628	425	2	.	.	PUNCT
admet-628	426	1	319	319	NUM
admet-628	426	2	(	(	PUNCT
admet-628	426	3	2006	2006	NUM
admet-628	426	4	)	)	PUNCT
admet-628	426	5	1477	1477	NUM
admet-628	426	6	-	-	SYM
admet-628	426	7	1484	1484	NUM
admet-628	426	8	.	.	PUNCT
admet-628	427	1	[	[	X
admet-628	427	2	3	3	X
admet-628	427	3	]	]	X
admet-628	427	4	f.g	f.g	NOUN
admet-628	427	5	.	.	PUNCT
admet-628	427	6	hayden	hayden	PROPN
admet-628	427	7	,	,	PUNCT
admet-628	427	8	j.j	j.j	PROPN
admet-628	427	9	.	.	PROPN
admet-628	427	10	treanor	treanor	PROPN
admet-628	427	11	,	,	PUNCT
admet-628	427	12	r.s	r.s	PROPN
admet-628	427	13	.	.	PROPN
admet-628	427	14	fritz	fritz	PROPN
admet-628	427	15	,	,	PUNCT
admet-628	427	16	m.	m.	PROPN
admet-628	427	17	lobo	lobo	PROPN
admet-628	427	18	betts	betts	PROPN
admet-628	427	19	,	,	PUNCT
admet-628	427	20	r.f	r.f	PROPN
admet-628	427	21	.	.	PROPN
admet-628	427	22	miller	miller	PROPN
admet-628	427	23	,	,	PUNCT
admet-628	427	24	m.n	m.n	PROPN
admet-628	427	25	.	.	PROPN
admet-628	427	26	kinnersley	kinnersley	PROPN
admet-628	427	27	,	,	PUNCT
admet-628	427	28	r.g	r.g	PROPN
admet-628	427	29	.	.	PROPN
admet-628	427	30	mills	mill	NOUN
admet-628	427	31	,	,	PUNCT
admet-628	427	32	p.	p.	PROPN
admet-628	427	33	ward	ward	PROPN
admet-628	427	34	,	,	PUNCT
admet-628	427	35	s.e	s.e	PROPN
admet-628	427	36	.	.	PROPN
admet-628	427	37	straus	straus	PROPN
admet-628	427	38	.	.	PUNCT
admet-628	427	39	use	use	NOUN
admet-628	427	40	of	of	ADP
admet-628	427	41	the	the	DET
admet-628	427	42	oral	oral	ADJ
admet-628	427	43	neuraminidase	neuraminidase	NOUN
admet-628	427	44	inhibitor	inhibitor	NOUN
admet-628	427	45	oseltamivir	oseltamivir	PROPN
admet-628	427	46	in	in	ADP
admet-628	427	47	experimental	experimental	ADJ
admet-628	427	48	human	human	ADJ
admet-628	427	49	influenza	influenza	NOUN
admet-628	427	50	:	:	PUNCT
admet-628	427	51	randomized	randomize	VERB
admet-628	427	52	controlled	control	VERB
admet-628	427	53	trials	trial	NOUN
admet-628	427	54	for	for	ADP
admet-628	427	55	prevention	prevention	NOUN
admet-628	427	56	and	and	CCONJ
admet-628	427	57	treatment	treatment	NOUN
admet-628	427	58	.	.	PUNCT
admet-628	428	1	jama	jama	PROPN
admet-628	428	2	282	282	NUM
admet-628	428	3	(	(	PUNCT
admet-628	428	4	1999	1999	NUM
admet-628	428	5	)	)	PUNCT
admet-628	428	6	1240	1240	NUM
admet-628	428	7	-	-	SYM
admet-628	428	8	1246	1246	NUM
admet-628	428	9	.	.	PUNCT
admet-628	429	1	[	[	X
admet-628	429	2	4	4	NUM
admet-628	429	3	]	]	X
admet-628	429	4	k.g	k.g	PROPN
admet-628	429	5	.	.	PROPN
admet-628	429	6	nicholson	nicholson	PROPN
admet-628	429	7	,	,	PUNCT
admet-628	429	8	f.y	f.y	PROPN
admet-628	429	9	.	.	PROPN
admet-628	429	10	aoki	aoki	PROPN
admet-628	429	11	,	,	PUNCT
admet-628	429	12	a.d	a.d	PROPN
admet-628	429	13	.	.	PROPN
admet-628	429	14	osterhaus	osterhaus	PROPN
admet-628	429	15	,	,	PUNCT
admet-628	429	16	s.	s.	PROPN
admet-628	429	17	trottier	trottier	PROPN
admet-628	429	18	,	,	PUNCT
admet-628	429	19	o.	o.	PROPN
admet-628	429	20	carewicz	carewicz	PROPN
admet-628	429	21	,	,	PUNCT
admet-628	429	22	c.h	c.h	PROPN
admet-628	429	23	.	.	PUNCT
admet-628	429	24	mercier	mercier	PROPN
admet-628	429	25	,	,	PUNCT
admet-628	429	26	a.	a.	NOUN
admet-628	429	27	rode	ride	VERB
admet-628	429	28	,	,	PUNCT
admet-628	429	29	n.	n.	PROPN
admet-628	429	30	kinnersley	kinnersley	PROPN
admet-628	429	31	,	,	PUNCT
admet-628	429	32	p	p	ADJ
admet-628	429	33	ward	ward	NOUN
admet-628	429	34	.	.	PUNCT
admet-628	430	1	efficacy	efficacy	NOUN
admet-628	430	2	and	and	CCONJ
admet-628	430	3	safety	safety	NOUN
admet-628	430	4	of	of	ADP
admet-628	430	5	oseltamivir	oseltamivir	NOUN
admet-628	430	6	in	in	ADP
admet-628	430	7	treatment	treatment	NOUN
admet-628	430	8	of	of	ADP
admet-628	430	9	acute	acute	ADJ
admet-628	430	10	influenza	influenza	NOUN
admet-628	430	11	:	:	PUNCT
admet-628	430	12	a	a	DET
admet-628	430	13	randomized	randomized	ADJ
admet-628	430	14	controlled	control	VERB
admet-628	430	15	trial	trial	NOUN
admet-628	430	16	.	.	PUNCT
admet-628	431	1	lancet	lancet	NOUN
admet-628	431	2	355	355	NUM
admet-628	431	3	(	(	PUNCT
admet-628	431	4	2000	2000	NUM
admet-628	431	5	)	)	PUNCT
admet-628	431	6	1845	1845	NUM
admet-628	431	7	-	-	SYM
admet-628	431	8	1850	1850	NUM
admet-628	431	9	.	.	PUNCT
admet-628	432	1	[	[	X
admet-628	432	2	5	5	NUM
admet-628	432	3	]	]	X
admet-628	432	4	fda	fda	PROPN
admet-628	432	5	,	,	PUNCT
admet-628	432	6	http://www.fda.gov/medwatch/safety/	http://www.fda.gov/medwatch/safety/	PROPN
admet-628	432	7	,	,	PUNCT
admet-628	432	8	safety	safety	NOUN
admet-628	432	9	alerts	alert	NOUN
admet-628	432	10	for	for	ADP
admet-628	432	11	human	human	ADJ
admet-628	432	12	medical	medical	ADJ
admet-628	432	13	products	product	NOUN
admet-628	432	14	(	(	PUNCT
admet-628	432	15	drugs	drug	NOUN
admet-628	432	16	,	,	PUNCT
admet-628	432	17	biologics	biologic	NOUN
admet-628	432	18	,	,	PUNCT
admet-628	432	19	medical	medical	ADJ
admet-628	432	20	devices	device	NOUN
admet-628	432	21	,	,	PUNCT
admet-628	432	22	special	special	ADJ
admet-628	432	23	nutritionals	nutritional	NOUN
admet-628	432	24	,	,	PUNCT
admet-628	432	25	and	and	CCONJ
admet-628	432	26	cosmetics	cosmetic	NOUN
admet-628	432	27	)	)	PUNCT
admet-628	432	28	.	.	PUNCT
admet-628	433	1	2008	2008	NUM
admet-628	433	2	/	/	SYM
admet-628	433	3	safety08.htm	safety08.htm	NOUN
admet-628	433	4	#	#	NOUN
admet-628	433	5	tamiflu	tamiflu	NOUN
admet-628	433	6	.	.	PUNCT
admet-628	433	7	posted	post	VERB
admet-628	433	8	on	on	ADP
admet-628	433	9	march	march	PROPN
admet-628	433	10	4	4	NUM
admet-628	434	1	[	[	X
admet-628	434	2	accessed	access	VERB
admet-628	434	3	06.11.08	06.11.08	NOUN
admet-628	434	4	]	]	PUNCT
admet-628	434	5	.	.	PUNCT
admet-628	435	1	http://www.fda.gov/medwatch/safety/	http://www.fda.gov/medwatch/safety/	PRON
admet-628	435	2	admet	admet	PROPN
admet-628	435	3	&	&	CCONJ
admet-628	435	4	dmpk	dmpk	PROPN
admet-628	435	5	7(1	7(1	PROPN
admet-628	435	6	)	)	PUNCT
admet-628	435	7	(	(	PUNCT
admet-628	435	8	2019	2019	NUM
admet-628	435	9	)	)	PUNCT
admet-628	435	10	22	22	NUM
admet-628	435	11	-	-	SYM
admet-628	435	12	43	43	NUM
admet-628	435	13	a	a	DET
admet-628	435	14	physiologically	physiologically	ADV
admet-628	435	15	-	-	PUNCT
admet-628	435	16	based	base	VERB
admet-628	435	17	pharmacokinetic	pharmacokinetic	ADJ
admet-628	435	18	model	model	NOUN
admet-628	435	19	for	for	ADP
admet-628	435	20	oseltamivir	oseltamivir	PROPN
admet-628	435	21	doi	doi	PROPN
admet-628	435	22	:	:	PUNCT
admet-628	435	23	10.5599	10.5599	NUM
admet-628	435	24	/	/	SYM
admet-628	435	25	admet.628	admet.628	PROPN
admet-628	435	26	39	39	NUM
admet-628	435	27	[	[	X
admet-628	435	28	6	6	NUM
admet-628	435	29	]	]	X
admet-628	435	30	n.	n.	NOUN
admet-628	435	31	goshima	goshima	PROPN
admet-628	435	32	,	,	PUNCT
admet-628	435	33	t.	t.	PROPN
admet-628	435	34	nakano	nakano	PROPN
admet-628	435	35	,	,	PUNCT
admet-628	435	36	m.	m.	NOUN
admet-628	435	37	nagao	nagao	ADJ
admet-628	435	38	,	,	PUNCT
admet-628	435	39	t.	t.	NOUN
admet-628	435	40	ihara	ihara	PROPN
admet-628	435	41	.	.	PUNCT
admet-628	436	1	a	a	DET
admet-628	436	2	clinical	clinical	ADJ
admet-628	436	3	study	study	NOUN
admet-628	436	4	of	of	ADP
admet-628	436	5	abnormal	abnormal	ADJ
admet-628	436	6	behaviors	behavior	NOUN
admet-628	436	7	in	in	ADP
admet-628	436	8	patients	patient	NOUN
admet-628	436	9	with	with	ADP
admet-628	436	10	influenza	influenza	NOUN
admet-628	436	11	.	.	PUNCT
admet-628	437	1	infect	infect	VERB
admet-628	437	2	.	.	PUNCT
admet-628	438	1	immun	immun	PROPN
admet-628	438	2	child	child	PROPN
admet-628	438	3	18	18	NUM
admet-628	438	4	(	(	PUNCT
admet-628	438	5	2006	2006	NUM
admet-628	438	6	)	)	PUNCT
admet-628	438	7	371	371	NUM
admet-628	438	8	-	-	SYM
admet-628	438	9	376	376	NUM
admet-628	438	10	.	.	PUNCT
admet-628	439	1	[	[	X
admet-628	439	2	7	7	X
admet-628	439	3	]	]	X
admet-628	439	4	s.	s.	PROPN
admet-628	439	5	toovey	toovey	PROPN
admet-628	439	6	,	,	PUNCT
admet-628	439	7	c.	c.	PROPN
admet-628	439	8	rayner	rayner	PROPN
admet-628	439	9	,	,	PUNCT
admet-628	439	10	e.	e.	PROPN
admet-628	439	11	prinssen	prinssen	PROPN
admet-628	439	12	,	,	PUNCT
admet-628	439	13	t.	t.	PROPN
admet-628	439	14	chu	chu	PROPN
admet-628	439	15	,	,	PUNCT
admet-628	439	16	b.	b.	PROPN
admet-628	439	17	donner	donner	PROPN
admet-628	439	18	,	,	PUNCT
admet-628	439	19	b.	b.	PROPN
admet-628	439	20	thakrar	thakrar	PROPN
admet-628	439	21	,	,	PUNCT
admet-628	439	22	r.	r.	PROPN
admet-628	439	23	dutkowski	dutkowski	PROPN
admet-628	439	24	,	,	PUNCT
admet-628	439	25	g.	g.	PROPN
admet-628	439	26	hoffmann	hoffmann	PROPN
admet-628	439	27	,	,	PUNCT
admet-628	439	28	a.	a.	NOUN
admet-628	439	29	breidenbach	breidenbach	PROPN
admet-628	439	30	,	,	PUNCT
admet-628	439	31	l.	l.	PROPN
admet-628	439	32	lindemann	lindemann	PROPN
admet-628	439	33	,	,	PUNCT
admet-628	439	34	e.	e.	PROPN
admet-628	439	35	carey	carey	PROPN
admet-628	439	36	,	,	PUNCT
admet-628	439	37	l.	l.	PROPN
admet-628	439	38	boak	boak	PROPN
admet-628	439	39	,	,	PUNCT
admet-628	439	40	r.	r.	PROPN
admet-628	439	41	gieschke	gieschke	PROPN
admet-628	439	42	,	,	PUNCT
admet-628	439	43	s.	s.	PROPN
admet-628	439	44	sacks	sacks	PROPN
admet-628	439	45	,	,	PUNCT
admet-628	439	46	j.	j.	PROPN
admet-628	439	47	solsky	solsky	PROPN
admet-628	439	48	,	,	PUNCT
admet-628	439	49	j.	j.	PROPN
admet-628	439	50	small	small	PROPN
admet-628	439	51	,	,	PUNCT
admet-628	439	52	d.	d.	PROPN
admet-628	439	53	reddy	reddy	PROPN
admet-628	439	54	.	.	PUNCT
admet-628	440	1	assessment	assessment	NOUN
admet-628	440	2	of	of	ADP
admet-628	440	3	neuropsychiatric	neuropsychiatric	ADJ
admet-628	440	4	adverse	adverse	ADJ
admet-628	440	5	events	event	NOUN
admet-628	440	6	in	in	ADP
admet-628	440	7	influenza	influenza	NOUN
admet-628	440	8	patients	patient	NOUN
admet-628	440	9	treated	treat	VERB
admet-628	440	10	with	with	ADP
admet-628	440	11	oseltamivir	oseltamivir	NOUN
admet-628	440	12	:	:	PUNCT
admet-628	440	13	a	a	DET
admet-628	440	14	comprehensive	comprehensive	ADJ
admet-628	440	15	review	review	NOUN
admet-628	440	16	.	.	PUNCT
admet-628	441	1	drug	drug	NOUN
admet-628	441	2	safety	safety	NOUN
admet-628	441	3	31	31	NUM
admet-628	441	4	(	(	PUNCT
admet-628	441	5	2008	2008	NUM
admet-628	441	6	)	)	PUNCT
admet-628	441	7	1097	1097	NUM
admet-628	441	8	-	-	SYM
admet-628	441	9	1114	1114	NUM
admet-628	441	10	.	.	PUNCT
admet-628	442	1	[	[	X
admet-628	442	2	8	8	NUM
admet-628	442	3	]	]	PUNCT
admet-628	442	4	k.	k.	PROPN
admet-628	442	5	morimoto	morimoto	PROPN
admet-628	442	6	,	,	PUNCT
admet-628	442	7	m.	m.	NOUN
admet-628	442	8	nakakariya	nakakariya	PROPN
admet-628	442	9	,	,	PUNCT
admet-628	442	10	y.	y.	PROPN
admet-628	442	11	shirasaka	shirasaka	PROPN
admet-628	442	12	,	,	PUNCT
admet-628	442	13	c.	c.	PROPN
admet-628	442	14	kakinuma	kakinuma	PROPN
admet-628	442	15	,	,	PUNCT
admet-628	442	16	t.	t.	PROPN
admet-628	442	17	fujita	fujita	PROPN
admet-628	442	18	,	,	PUNCT
admet-628	442	19	l.	l.	PROPN
admet-628	442	20	tamai	tamai	PROPN
admet-628	442	21	,	,	PUNCT
admet-628	442	22	t.	t.	PROPN
admet-628	442	23	ogihara	ogihara	PROPN
admet-628	442	24	.	.	PUNCT
admet-628	443	1	oseltamivir	oseltamivir	PROPN
admet-628	443	2	(	(	PUNCT
admet-628	443	3	tamiflu	tamiflu	PROPN
admet-628	443	4	)	)	PUNCT
admet-628	443	5	efflux	efflux	VERB
admet-628	443	6	transport	transport	NOUN
admet-628	443	7	at	at	ADP
admet-628	443	8	the	the	DET
admet-628	443	9	blood	blood	NOUN
admet-628	443	10	-	-	PUNCT
admet-628	443	11	brain	brain	NOUN
admet-628	443	12	barrier	barrier	NOUN
admet-628	443	13	via	via	ADP
admet-628	443	14	p	p	NOUN
admet-628	443	15	-	-	PUNCT
admet-628	443	16	glycoprotein	glycoprotein	NOUN
admet-628	443	17	.	.	PUNCT
admet-628	444	1	drug	drug	NOUN
admet-628	444	2	metab	metab	NOUN
admet-628	444	3	.	.	PUNCT
admet-628	445	1	dispos	dispos	PROPN
admet-628	445	2	.	.	PUNCT
admet-628	446	1	36	36	NUM
admet-628	446	2	(	(	PUNCT
admet-628	446	3	2008	2008	NUM
admet-628	446	4	)	)	PUNCT
admet-628	446	5	6	6	NUM
admet-628	446	6	-	-	SYM
admet-628	446	7	9	9	NUM
admet-628	446	8	.	.	PUNCT
admet-628	447	1	[	[	X
admet-628	447	2	9	9	NUM
admet-628	447	3	]	]	X
admet-628	447	4	g.	g.	PROPN
admet-628	447	5	hoffmann	hoffmann	PROPN
admet-628	447	6	,	,	PUNCT
admet-628	447	7	c.	c.	PROPN
admet-628	447	8	funk	funk	NOUN
admet-628	447	9	,	,	PUNCT
admet-628	447	10	s.	s.	PROPN
admet-628	447	11	fowler	fowler	PROPN
admet-628	447	12	,	,	PUNCT
admet-628	447	13	m.b	m.b	PROPN
admet-628	447	14	.	.	PROPN
admet-628	447	15	otteneder	otteneder	PROPN
admet-628	447	16	,	,	PUNCT
admet-628	447	17	a.	a.	NOUN
admet-628	447	18	breidenbach	breidenbach	PROPN
admet-628	447	19	,	,	PUNCT
admet-628	447	20	c.r	c.r	PROPN
admet-628	447	21	.	.	PROPN
admet-628	447	22	rayner	rayner	PROPN
admet-628	447	23	,	,	PUNCT
admet-628	447	24	t.	t.	PROPN
admet-628	447	25	chu	chu	PROPN
admet-628	447	26	,	,	PUNCT
admet-628	447	27	e.p	e.p	PROPN
admet-628	447	28	.	.	PROPN
admet-628	447	29	prinssen	prinssen	NOUN
admet-628	447	30	.	.	PUNCT
admet-628	448	1	nonclinical	nonclinical	ADJ
admet-628	448	2	pharmacokinetics	pharmacokinetic	NOUN
admet-628	448	3	of	of	ADP
admet-628	448	4	oseltamivir	oseltamivir	PROPN
admet-628	448	5	and	and	CCONJ
admet-628	448	6	oseltamivir	oseltamivir	PROPN
admet-628	448	7	carboxylate	carboxylate	VERB
admet-628	448	8	in	in	ADP
admet-628	448	9	the	the	DET
admet-628	448	10	central	central	ADJ
admet-628	448	11	nervous	nervous	ADJ
admet-628	448	12	system	system	NOUN
admet-628	448	13	,	,	PUNCT
admet-628	448	14	antimicrob	antimicrob	PROPN
admet-628	448	15	.	.	PUNCT
admet-628	449	1	agents	agents	PROPN
admet-628	449	2	chemother	chemother	PROPN
admet-628	449	3	.	.	PUNCT
admet-628	450	1	53	53	NUM
admet-628	450	2	(	(	PUNCT
admet-628	450	3	2009	2009	NUM
admet-628	450	4	)	)	PUNCT
admet-628	450	5	753	753	NUM
admet-628	450	6	-	-	SYM
admet-628	450	7	4761	4761	NUM
admet-628	450	8	[	[	SYM
admet-628	450	9	10	10	NUM
admet-628	450	10	]	]	X
admet-628	450	11	s.m	s.m	PROPN
admet-628	450	12	.	.	PROPN
admet-628	450	13	crain	crain	PROPN
admet-628	450	14	,	,	PUNCT
admet-628	450	15	k.f	k.f	PROPN
admet-628	450	16	.	.	PROPN
admet-628	450	17	shen	shen	PROPN
admet-628	450	18	.	.	PUNCT
admet-628	451	1	neuraminidase	neuraminidase	PROPN
admet-628	451	2	inhibitor	inhibitor	NOUN
admet-628	451	3	,	,	PUNCT
admet-628	451	4	oseltamivir	oseltamivir	PROPN
admet-628	451	5	blocks	block	VERB
admet-628	451	6	gm1	gm1	PROPN
admet-628	451	7	ganglioside	ganglioside	NOUN
admet-628	451	8	-	-	PUNCT
admet-628	451	9	regulated	regulate	VERB
admet-628	451	10	excitatotory	excitatotory	ADJ
admet-628	451	11	opioid	opioid	ADJ
admet-628	451	12	receptor	receptor	NOUN
admet-628	451	13	-	-	PUNCT
admet-628	451	14	mediated	mediate	VERB
admet-628	451	15	hyperalgesia	hyperalgesia	NOUN
admet-628	451	16	,	,	PUNCT
admet-628	451	17	enhances	enhance	VERB
admet-628	451	18	opioid	opioid	ADJ
admet-628	451	19	analgesia	analgesia	NOUN
admet-628	451	20	and	and	CCONJ
admet-628	451	21	attenuates	attenuate	VERB
admet-628	451	22	tolerance	tolerance	NOUN
admet-628	451	23	in	in	ADP
admet-628	451	24	mice	mouse	NOUN
admet-628	451	25	.	.	PUNCT
admet-628	452	1	brain	brain	NOUN
admet-628	452	2	res	re	NOUN
admet-628	452	3	.	.	PUNCT
admet-628	453	1	995	995	NUM
admet-628	453	2	(	(	PUNCT
admet-628	453	3	2004	2004	NUM
admet-628	453	4	)	)	PUNCT
admet-628	453	5	260	260	NUM
admet-628	453	6	-	-	SYM
admet-628	453	7	266	266	NUM
admet-628	453	8	.	.	PUNCT
admet-628	454	1	[	[	X
admet-628	454	2	11	11	NUM
admet-628	454	3	]	]	X
admet-628	454	4	h.	h.	PROPN
admet-628	454	5	ono	ono	PROPN
admet-628	454	6	,	,	PUNCT
admet-628	454	7	y.	y.	PROPN
admet-628	454	8	nagano	nagano	PROPN
admet-628	454	9	,	,	PUNCT
admet-628	454	10	n.	n.	PROPN
admet-628	454	11	matsunami	matsunami	PROPN
admet-628	454	12	,	,	PUNCT
admet-628	454	13	s.	s.	PROPN
admet-628	454	14	sugiyama	sugiyama	PROPN
admet-628	454	15	,	,	PUNCT
admet-628	454	16	s.	s.	PROPN
admet-628	454	17	yamamoto	yamamoto	PROPN
admet-628	454	18	,	,	PUNCT
admet-628	454	19	m.	m.	NOUN
admet-628	454	20	tanabe	tanabe	PROPN
admet-628	454	21	.	.	PUNCT
admet-628	455	1	oseltamivir	oseltamivir	PROPN
admet-628	455	2	,	,	PUNCT
admet-628	455	3	an	an	DET
admet-628	455	4	antiinfluenza	antiinfluenza	ADJ
admet-628	455	5	virus	virus	NOUN
admet-628	455	6	drug	drug	NOUN
admet-628	455	7	,	,	PUNCT
admet-628	455	8	produces	produce	VERB
admet-628	455	9	hypothermia	hypothermia	NOUN
admet-628	455	10	in	in	ADP
admet-628	455	11	mice	mouse	NOUN
admet-628	455	12	.	.	PUNCT
admet-628	456	1	biol	biol	PROPN
admet-628	456	2	.	.	PUNCT
admet-628	457	1	pharm	pharm	PROPN
admet-628	457	2	.	.	PUNCT
admet-628	458	1	bull	bull	NOUN
admet-628	458	2	.	.	PUNCT
admet-628	459	1	31	31	NUM
admet-628	459	2	(	(	PUNCT
admet-628	459	3	2008	2008	NUM
admet-628	459	4	)	)	PUNCT
admet-628	459	5	638	638	NUM
admet-628	459	6	-	-	SYM
admet-628	459	7	642	642	NUM
admet-628	459	8	.	.	PUNCT
admet-628	460	1	[	[	X
admet-628	460	2	12	12	NUM
admet-628	460	3	]	]	X
admet-628	460	4	y.	y.	PROPN
admet-628	460	5	izumi	izumi	PROPN
admet-628	460	6	,	,	PUNCT
admet-628	460	7	k.	k.	PROPN
admet-628	460	8	tokuda	tokuda	PROPN
admet-628	460	9	,	,	PUNCT
admet-628	460	10	k.a	k.a	PROPN
admet-628	460	11	.	.	PROPN
admet-628	460	12	o’dell	o’dell	PROPN
admet-628	460	13	,	,	PUNCT
admet-628	460	14	c.f	c.f	PROPN
admet-628	460	15	.	.	PROPN
admet-628	460	16	zorumski	zorumski	PROPN
admet-628	460	17	,	,	PUNCT
admet-628	460	18	t.	t.	PROPN
admet-628	460	19	narahashi	narahashi	PROPN
admet-628	460	20	.	.	PUNCT
admet-628	461	1	neuroexcitatory	neuroexcitatory	ADJ
admet-628	461	2	actions	action	NOUN
admet-628	461	3	of	of	ADP
admet-628	461	4	tamiflu	tamiflu	PROPN
admet-628	461	5	and	and	CCONJ
admet-628	461	6	its	its	PRON
admet-628	461	7	carboxylate	carboxylate	NOUN
admet-628	461	8	metabolite	metabolite	NOUN
admet-628	461	9	.	.	PUNCT
admet-628	462	1	neurosci	neurosci	PROPN
admet-628	462	2	.	.	PUNCT
admet-628	463	1	lett	lett	PROPN
admet-628	463	2	.	.	PUNCT
admet-628	464	1	426	426	NUM
admet-628	464	2	(	(	PUNCT
admet-628	464	3	2007	2007	NUM
admet-628	464	4	)	)	PUNCT
admet-628	464	5	54	54	NUM
admet-628	464	6	-	-	SYM
admet-628	464	7	58	58	NUM
admet-628	464	8	.	.	PUNCT
admet-628	465	1	[	[	X
admet-628	465	2	13	13	NUM
admet-628	465	3	]	]	X
admet-628	465	4	d.	d.	PROPN
admet-628	465	5	sweeny	sweeny	PROPN
admet-628	465	6	,	,	PUNCT
admet-628	465	7	g.	g.	PROPN
admet-628	465	8	lynch	lynch	PROPN
admet-628	465	9	,	,	PUNCT
admet-628	465	10	a.m.	a.m.	PROPN
admet-628	465	11	bidgood	bidgood	PROPN
admet-628	465	12	,	,	PUNCT
admet-628	465	13	w.	w.	PROPN
admet-628	465	14	lew	lew	PROPN
admet-628	465	15	,	,	PUNCT
admet-628	465	16	k.y.wang	k.y.wang	PROPN
admet-628	465	17	,	,	PUNCT
admet-628	465	18	k.c	k.c	PROPN
admet-628	465	19	.	.	PROPN
admet-628	465	20	cundy	cundy	PROPN
admet-628	465	21	.	.	PUNCT
admet-628	466	1	metabolism	metabolism	NOUN
admet-628	466	2	of	of	ADP
admet-628	466	3	the	the	DET
admet-628	466	4	influenza	influenza	NOUN
admet-628	466	5	neurominidase	neurominidase	NOUN
admet-628	466	6	inhibitor	inhibitor	NOUN
admet-628	466	7	prodrugoseltamivir	prodrugoseltamivir	PROPN
admet-628	466	8	in	in	ADP
admet-628	466	9	the	the	DET
admet-628	466	10	rat	rat	PROPN
admet-628	466	11	.	.	PROPN
admet-628	466	12	drug	drug	PROPN
admet-628	466	13	metab	metab	NOUN
admet-628	466	14	.	.	PUNCT
admet-628	467	1	dispos	dispos	PROPN
admet-628	467	2	.	.	PUNCT
admet-628	468	1	28	28	NUM
admet-628	468	2	(	(	PUNCT
admet-628	468	3	2000	2000	NUM
admet-628	468	4	)	)	PUNCT
admet-628	468	5	737	737	NUM
admet-628	468	6	-	-	SYM
admet-628	468	7	774	774	NUM
admet-628	468	8	.	.	PUNCT
admet-628	469	1	[	[	X
admet-628	469	2	14	14	NUM
admet-628	469	3	]	]	X
admet-628	469	4	g.	g.	PROPN
admet-628	470	1	he	he	PRON
admet-628	470	2	,	,	PUNCT
admet-628	470	3	j.	j.	PROPN
admet-628	470	4	massarella	massarella	PROPN
admet-628	470	5	,	,	PUNCT
admet-628	470	6	p.	p.	NOUN
admet-628	470	7	ward	ward	NOUN
admet-628	470	8	.	.	PUNCT
admet-628	471	1	clinical	clinical	ADJ
admet-628	471	2	pharmacokinetics	pharmacokinetic	NOUN
admet-628	471	3	of	of	ADP
admet-628	471	4	the	the	DET
admet-628	471	5	prodrug	prodrug	NOUN
admet-628	471	6	oseltamivir	oseltamivir	PROPN
admet-628	471	7	and	and	CCONJ
admet-628	471	8	its	its	PRON
admet-628	471	9	active	active	ADJ
admet-628	471	10	metabolic	metabolic	NOUN
admet-628	471	11	ro	ro	NOUN
admet-628	471	12	64	64	NUM
admet-628	471	13	-	-	SYM
admet-628	471	14	0802	0802	NUM
admet-628	471	15	,	,	PUNCT
admet-628	471	16	clin	clin	PROPN
admet-628	471	17	.	.	PUNCT
admet-628	472	1	pharmacokinet	pharmacokinet	PROPN
admet-628	472	2	.	.	PUNCT
admet-628	473	1	37	37	NUM
admet-628	473	2	(	(	PUNCT
admet-628	473	3	1999	1999	NUM
admet-628	473	4	)	)	PUNCT
admet-628	473	5	471	471	NUM
admet-628	473	6	-	-	SYM
admet-628	473	7	484	484	NUM
admet-628	473	8	.	.	PUNCT
admet-628	474	1	[	[	X
admet-628	474	2	15	15	NUM
admet-628	474	3	]	]	X
admet-628	474	4	a.	a.	NOUN
admet-628	474	5	hatori	hatori	PROPN
admet-628	474	6	,	,	PUNCT
admet-628	474	7	t.	t.	PROPN
admet-628	474	8	arai	arai	PROPN
admet-628	474	9	,	,	PUNCT
admet-628	474	10	k.	k.	PROPN
admet-628	474	11	yanamoto	yanamoto	PROPN
admet-628	474	12	,	,	PUNCT
admet-628	474	13	t.	t.	PROPN
admet-628	474	14	yamasaki	yamasaki	PROPN
admet-628	474	15	,	,	PUNCT
admet-628	474	16	y.	y.	PROPN
admet-628	474	17	kawamura	kawamura	PROPN
admet-628	474	18	,	,	PUNCT
admet-628	474	19	j.	j.	PROPN
admet-628	474	20	yui	yui	PROPN
admet-628	474	21	,	,	PUNCT
admet-628	474	22	f.	f.	PROPN
admet-628	474	23	konno	konno	PROPN
admet-628	474	24	,	,	PUNCT
admet-628	474	25	r.	r.	PROPN
admet-628	474	26	nakao	nakao	PROPN
admet-628	474	27	,	,	PUNCT
admet-628	474	28	k.	k.	PROPN
admet-628	474	29	suzuki	suzuki	PROPN
admet-628	474	30	,	,	PUNCT
admet-628	474	31	m.r	m.r	PROPN
admet-628	474	32	.	.	PROPN
admet-628	474	33	zhang	zhang	PROPN
admet-628	474	34	.	.	PUNCT
admet-628	474	35	biodistribution	biodistribution	NOUN
admet-628	474	36	and	and	CCONJ
admet-628	474	37	metabolism	metabolism	NOUN
admet-628	474	38	of	of	ADP
admet-628	474	39	the	the	DET
admet-628	474	40	anti	anti	ADJ
admet-628	474	41	-	-	ADJ
admet-628	474	42	influenza	influenza	ADJ
admet-628	474	43	drug	drug	NOUN
admet-628	474	44	[	[	X
admet-628	474	45	11c]oseltamivir	11c]oseltamivir	NUM
admet-628	474	46	and	and	CCONJ
admet-628	474	47	its	its	PRON
admet-628	474	48	active	active	ADJ
admet-628	474	49	metabolite	metabolite	NOUN
admet-628	474	50	[	[	PUNCT
admet-628	474	51	11c]ro	11c]ro	NUM
admet-628	474	52	64	64	NUM
admet-628	474	53	-	-	SYM
admet-628	474	54	0802	0802	NUM
admet-628	474	55	in	in	ADP
admet-628	474	56	mice	mouse	NOUN
admet-628	474	57	.	.	PUNCT
admet-628	475	1	nucl	nucl	PROPN
admet-628	475	2	.	.	PUNCT
admet-628	476	1	med	med	PROPN
admet-628	476	2	.	.	PUNCT
admet-628	477	1	biol	biol	PROPN
admet-628	477	2	.	.	PUNCT
admet-628	478	1	36	36	NUM
admet-628	478	2	(	(	PUNCT
admet-628	478	3	2009	2009	NUM
admet-628	478	4	)	)	PUNCT
admet-628	478	5	47	47	NUM
admet-628	478	6	-	-	SYM
admet-628	478	7	55	55	NUM
admet-628	478	8	.	.	PUNCT
admet-628	479	1	[	[	X
admet-628	479	2	16	16	NUM
admet-628	479	3	]	]	X
admet-628	479	4	w.	w.	PROPN
admet-628	479	5	li	li	PROPN
admet-628	479	6	,	,	PUNCT
admet-628	479	7	p.a	p.a	PROPN
admet-628	479	8	.	.	PROPN
admet-628	479	9	escarpe	escarpe	PROPN
admet-628	479	10	,	,	PUNCT
admet-628	479	11	e.j	e.j	PROPN
admet-628	479	12	.	.	PROPN
admet-628	479	13	eisenberg	eisenberg	PROPN
admet-628	479	14	,	,	PUNCT
admet-628	479	15	k.c	k.c	PROPN
admet-628	479	16	.	.	PROPN
admet-628	479	17	cundy	cundy	PROPN
admet-628	479	18	,	,	PUNCT
admet-628	479	19	c.	c.	PROPN
admet-628	479	20	sweet	sweet	PROPN
admet-628	479	21	,	,	PUNCT
admet-628	479	22	k.j	k.j	PROPN
admet-628	479	23	.	.	PROPN
admet-628	479	24	jakeman	jakeman	PROPN
admet-628	479	25	,	,	PUNCT
admet-628	479	26	j.	j.	PROPN
admet-628	479	27	merson	merson	PROPN
admet-628	479	28	,	,	PUNCT
admet-628	479	29	w.	w.	PROPN
admet-628	479	30	lew	lew	PROPN
admet-628	479	31	,	,	PUNCT
admet-628	479	32	m.	m.	NOUN
admet-628	479	33	williams	williams	PROPN
admet-628	479	34	,	,	PUNCT
admet-628	479	35	l.	l.	PROPN
admet-628	479	36	zhang	zhang	PROPN
admet-628	479	37	,	,	PUNCT
admet-628	479	38	c.u	c.u	PROPN
admet-628	479	39	.	.	PROPN
admet-628	479	40	kim	kim	PROPN
admet-628	479	41	,	,	PUNCT
admet-628	479	42	n.	n.	NOUN
admet-628	479	43	bischofberger	bischofberger	NOUN
admet-628	479	44	,	,	PUNCT
admet-628	479	45	m.s	m.s	PROPN
admet-628	479	46	.	.	PROPN
admet-628	479	47	chen	chen	PROPN
admet-628	479	48	,	,	PUNCT
admet-628	479	49	d.b	d.b	PROPN
admet-628	479	50	.	.	PROPN
admet-628	479	51	mendel	mendel	PROPN
admet-628	479	52	.	.	PUNCT
admet-628	479	53	identification	identification	NOUN
admet-628	479	54	of	of	ADP
admet-628	479	55	gs	gs	PROPN
admet-628	479	56	4104	4104	NUM
admet-628	479	57	as	as	ADP
admet-628	479	58	an	an	DET
admet-628	479	59	orally	orally	ADV
admet-628	479	60	bioavailable	bioavailable	ADJ
admet-628	479	61	prodrug	prodrug	NOUN
admet-628	479	62	of	of	ADP
admet-628	479	63	the	the	DET
admet-628	479	64	influenza	influenza	NOUN
admet-628	479	65	virus	virus	PROPN
admet-628	479	66	neurominidase	neurominidase	NOUN
admet-628	479	67	inhibitor	inhibitor	NOUN
admet-628	479	68	gs	gs	PROPN
admet-628	479	69	4071	4071	NUM
admet-628	479	70	.	.	PUNCT
admet-628	480	1	antimicrob	antimicrob	PROPN
admet-628	480	2	.	.	PUNCT
admet-628	481	1	agents	agent	NOUN
admet-628	481	2	chemother	chemother	PROPN
admet-628	481	3	.	.	PUNCT
admet-628	482	1	42	42	NUM
admet-628	482	2	(	(	PUNCT
admet-628	482	3	1998	1998	NUM
admet-628	482	4	)	)	PUNCT
admet-628	482	5	647	647	NUM
admet-628	482	6	-	-	SYM
admet-628	482	7	653	653	NUM
admet-628	482	8	.	.	PUNCT
admet-628	483	1	[	[	X
admet-628	483	2	17	17	NUM
admet-628	483	3	]	]	PUNCT
admet-628	483	4	m.	m.	NOUN
admet-628	483	5	kurowski	kurowski	PROPN
admet-628	483	6	,	,	PUNCT
admet-628	483	7	c.	c.	PROPN
admet-628	483	8	oo	oo	PROPN
admet-628	483	9	,	,	PUNCT
admet-628	483	10	h.	h.	PROPN
admet-628	483	11	wiltshire	wiltshire	PROPN
admet-628	483	12	.	.	PUNCT
admet-628	484	1	oseltamivir	oseltamivir	PROPN
admet-628	484	2	distributes	distribute	VERB
admet-628	484	3	to	to	ADP
admet-628	484	4	influenza	influenza	NOUN
admet-628	484	5	virus	virus	NOUN
admet-628	484	6	replication	replication	NOUN
admet-628	484	7	sites	site	NOUN
admet-628	484	8	in	in	ADP
admet-628	484	9	the	the	DET
admet-628	484	10	middle	middle	ADJ
admet-628	484	11	ear	ear	NOUN
admet-628	484	12	and	and	CCONJ
admet-628	484	13	sinuses	sinus	NOUN
admet-628	484	14	.	.	PUNCT
admet-628	485	1	clin	clin	PROPN
admet-628	485	2	.	.	PUNCT
admet-628	486	1	drug	drug	PROPN
admet-628	486	2	invest	invest	PROPN
admet-628	486	3	.	.	PUNCT
admet-628	487	1	24	24	NUM
admet-628	487	2	(	(	PUNCT
admet-628	487	3	2004	2004	NUM
admet-628	487	4	)	)	PUNCT
admet-628	487	5	49	49	NUM
admet-628	487	6	-	-	SYM
admet-628	487	7	53	53	NUM
admet-628	487	8	.	.	PUNCT
admet-628	488	1	[	[	X
admet-628	488	2	18	18	NUM
admet-628	488	3	]	]	X
admet-628	488	4	m.e	m.e	PROPN
admet-628	488	5	.	.	PROPN
admet-628	488	6	andersen	andersen	PROPN
admet-628	488	7	.	.	PROPN
admet-628	488	8	tissue	tissue	NOUN
admet-628	488	9	dosimetry	dosimetry	NOUN
admet-628	488	10	in	in	ADP
admet-628	488	11	risk	risk	NOUN
admet-628	488	12	assessment	assessment	NOUN
admet-628	488	13	,	,	PUNCT
admet-628	488	14	or	or	CCONJ
admet-628	488	15	what	what	PRON
admet-628	488	16	’s	’	VERB
admet-628	488	17	the	the	DET
admet-628	488	18	problem	problem	NOUN
admet-628	488	19	here	here	ADV
admet-628	488	20	anyway	anyway	ADV
admet-628	488	21	?	?	PUNCT
admet-628	489	1	in	in	ADP
admet-628	489	2	:	:	PUNCT
admet-628	489	3	pharmacokinetics	pharmacokinetic	NOUN
admet-628	489	4	in	in	ADP
admet-628	489	5	risk	risk	NOUN
admet-628	489	6	assessment	assessment	NOUN
admet-628	489	7	,	,	PUNCT
admet-628	489	8	drinking	drink	VERB
admet-628	489	9	water	water	NOUN
admet-628	489	10	and	and	CCONJ
admet-628	489	11	health	health	NOUN
admet-628	489	12	.	.	PUNCT
admet-628	490	1	pp	pp	ADP
admet-628	490	2	8	8	NUM
admet-628	490	3	-	-	SYM
admet-628	490	4	23	23	NUM
admet-628	490	5	(	(	PUNCT
admet-628	490	6	1987	1987	NUM
admet-628	490	7	)	)	PUNCT
admet-628	490	8	,	,	PUNCT
admet-628	490	9	national	national	PROPN
admet-628	490	10	academy	academy	PROPN
admet-628	490	11	press	press	PROPN
admet-628	490	12	,	,	PUNCT
admet-628	490	13	washington	washington	PROPN
admet-628	490	14	dc	dc	PROPN
admet-628	490	15	.	.	PUNCT
admet-628	491	1	[	[	X
admet-628	491	2	19	19	NUM
admet-628	491	3	]	]	PUNCT
admet-628	491	4	who	who	PRON
admet-628	491	5	,	,	PUNCT
admet-628	491	6	international	international	ADJ
admet-628	491	7	programme	programme	NOUN
admet-628	491	8	on	on	ADP
admet-628	491	9	chemical	chemical	NOUN
admet-628	491	10	safety	safety	NOUN
admet-628	491	11	,	,	PUNCT
admet-628	491	12	characterization	characterization	NOUN
admet-628	491	13	and	and	CCONJ
admet-628	491	14	application	application	NOUN
admet-628	491	15	of	of	ADP
admet-628	491	16	physiologically	physiologically	ADV
admet-628	491	17	based	base	VERB
admet-628	491	18	pharmacokinetic	pharmacokinetic	ADJ
admet-628	491	19	models	model	NOUN
admet-628	491	20	in	in	ADP
admet-628	491	21	risk	risk	NOUN
admet-628	491	22	assessment	assessment	NOUN
admet-628	491	23	.	.	PUNCT
admet-628	492	1	harmonization	harmonization	NOUN
admet-628	492	2	project	project	NOUN
admet-628	492	3	document	document	NOUN
admet-628	492	4	,	,	PUNCT
admet-628	492	5	no	no	INTJ
admet-628	492	6	.	.	NOUN
admet-628	492	7	9	9	NUM
admet-628	492	8	(	(	PUNCT
admet-628	492	9	2010	2010	NUM
admet-628	492	10	)	)	PUNCT
admet-628	492	11	,	,	PUNCT
admet-628	492	12	who	who	PRON
admet-628	492	13	press	press	VERB
admet-628	492	14	,	,	PUNCT
admet-628	492	15	geneva	geneva	PROPN
admet-628	492	16	27	27	NUM
admet-628	492	17	,	,	PUNCT
admet-628	492	18	switzerland	switzerland	PROPN
admet-628	492	19	.	.	PUNCT
admet-628	493	1	[	[	X
admet-628	493	2	20	20	NUM
admet-628	493	3	]	]	X
admet-628	493	4	n.	n.	PROPN
admet-628	493	5	parrott	parrott	PROPN
admet-628	493	6	,	,	PUNCT
admet-628	493	7	b.	b.	PROPN
admet-628	493	8	davies	davies	PROPN
admet-628	493	9	,	,	PUNCT
admet-628	493	10	g.	g.	PROPN
admet-628	493	11	hoffmann	hoffmann	PROPN
admet-628	493	12	,	,	PUNCT
admet-628	493	13	a.	a.	NOUN
admet-628	493	14	koerner	koerner	PROPN
admet-628	493	15	,	,	PUNCT
admet-628	493	16	t.	t.	PROPN
admet-628	493	17	lave	lave	PROPN
admet-628	493	18	,	,	PUNCT
admet-628	493	19	e.	e.	PROPN
admet-628	493	20	prinssen	prinssen	PROPN
admet-628	493	21	,	,	PUNCT
admet-628	493	22	e.	e.	PROPN
admet-628	493	23	theogaraj	theogaraj	PROPN
admet-628	493	24	,	,	PUNCT
admet-628	493	25	t.	t.	PROPN
admet-628	493	26	singer	singer	NOUN
admet-628	493	27	.	.	PUNCT
admet-628	494	1	development	development	NOUN
admet-628	494	2	of	of	ADP
admet-628	494	3	a	a	DET
admet-628	494	4	physiologically	physiologically	ADV
admet-628	494	5	based	base	VERB
admet-628	494	6	model	model	NOUN
admet-628	494	7	for	for	ADP
admet-628	494	8	oseltamivir	oseltamivir	PROPN
admet-628	494	9	and	and	CCONJ
admet-628	494	10	simulation	simulation	NOUN
admet-628	494	11	of	of	ADP
admet-628	494	12	pharmacokinetics	pharmacokinetic	NOUN
admet-628	494	13	in	in	ADP
admet-628	494	14	neonates	neonate	NOUN
admet-628	494	15	and	and	CCONJ
admet-628	494	16	infants	infant	NOUN
admet-628	494	17	.	.	PUNCT
admet-628	495	1	clin	clin	PROPN
admet-628	495	2	.	.	PUNCT
admet-628	495	3	pharmacokinet	pharmacokinet	NOUN
admet-628	495	4	.	.	PUNCT
admet-628	496	1	50(9	50(9	NUM
admet-628	496	2	)	)	PUNCT
admet-628	496	3	(	(	PUNCT
admet-628	496	4	2011	2011	NUM
admet-628	496	5	)	)	PUNCT
admet-628	496	6	613	613	NUM
admet-628	496	7	-	-	SYM
admet-628	496	8	623	623	NUM
admet-628	496	9	.	.	PUNCT
admet-628	497	1	[	[	X
admet-628	497	2	21	21	NUM
admet-628	497	3	]	]	PUNCT
admet-628	497	4	m.	m.	NOUN
admet-628	497	5	boberg	boberg	PROPN
admet-628	497	6	,	,	PUNCT
admet-628	497	7	m.vrana	m.vrana	PROPN
admet-628	497	8	,	,	PUNCT
admet-628	497	9	a.	a.	PROPN
admet-628	497	10	mehrotra	mehrotra	PROPN
admet-628	497	11	,	,	PUNCT
admet-628	497	12	r.	r.	PROPN
admet-628	497	13	e.	e.	PROPN
admet-628	497	14	pearce	pearce	PROPN
admet-628	497	15	,	,	PUNCT
admet-628	497	16	a.	a.	NOUN
admet-628	497	17	gaedigk	gaedigk	PROPN
admet-628	497	18	,	,	PUNCT
admet-628	497	19	d.k.bhatt	d.k.bhatt	PROPN
admet-628	497	20	,	,	PUNCT
admet-628	497	21	j.	j.	PROPN
admet-628	497	22	s.leeder	s.leeder	PROPN
admet-628	497	23	,	,	PUNCT
admet-628	497	24	b.	b.	PROPN
admet-628	497	25	prasad	prasad	PROPN
admet-628	497	26	.	.	PUNCT
admet-628	498	1	agedependent	agedependent	PROPN
admet-628	498	2	absolute	absolute	PROPN
admet-628	498	3	abundance	abundance	NOUN
admet-628	498	4	of	of	ADP
admet-628	498	5	hepatic	hepatic	ADJ
admet-628	498	6	carboxylesterases	carboxylesterase	NOUN
admet-628	498	7	(	(	PUNCT
admet-628	498	8	ces1	ces1	NOUN
admet-628	498	9	and	and	CCONJ
admet-628	498	10	ces2	ces2	PROPN
admet-628	498	11	)	)	PUNCT
admet-628	498	12	by	by	ADP
admet-628	498	13	lc	lc	PROPN
admet-628	498	14	-	-	PUNCT
admet-628	498	15	ms	ms	PROPN
admet-628	498	16	/	/	SYM
admet-628	498	17	ms	ms	PROPN
admet-628	498	18	proteomics	proteomic	NOUN
admet-628	498	19	:	:	PUNCT
admet-628	498	20	application	application	NOUN
admet-628	498	21	to	to	ADP
admet-628	498	22	pbpk	pbpk	PROPN
admet-628	498	23	modeling	modeling	NOUN
admet-628	498	24	of	of	ADP
admet-628	498	25	oseltamivirin	oseltamivirin	NOUN
admet-628	498	26	vivo	vivo	NOUN
admet-628	498	27	pharmacokinetics	pharmacokinetic	NOUN
admet-628	498	28	in	in	ADP
admet-628	498	29	infants	infant	NOUN
admet-628	498	30	,	,	PUNCT
admet-628	498	31	drug	drug	NOUN
admet-628	498	32	metab	metab	NOUN
admet-628	498	33	.	.	PUNCT
admet-628	499	1	dispos	dispos	PROPN
admet-628	499	2	.	.	PUNCT
admet-628	500	1	45	45	NUM
admet-628	500	2	(	(	PUNCT
admet-628	500	3	2017	2017	NUM
admet-628	500	4	)	)	PUNCT
admet-628	500	5	216–223	216–223	NUM
admet-628	500	6	.	.	PUNCT
admet-628	501	1	[	[	X
admet-628	501	2	22	22	NUM
admet-628	501	3	]	]	X
admet-628	501	4	i.	i.	PROPN
admet-628	501	5	nestorov	nestorov	PROPN
admet-628	501	6	.	.	PUNCT
admet-628	502	1	whole	whole	ADJ
admet-628	502	2	body	body	NOUN
admet-628	502	3	pharmacokinetic	pharmacokinetic	ADJ
admet-628	502	4	models	model	NOUN
admet-628	502	5	.	.	PUNCT
admet-628	503	1	clin	clin	PROPN
admet-628	503	2	.	.	PUNCT
admet-628	503	3	pharmacokinet	pharmacokinet	PROPN
admet-628	503	4	.	.	PUNCT
admet-628	504	1	42	42	NUM
admet-628	504	2	(	(	PUNCT
admet-628	504	3	2003	2003	NUM
admet-628	504	4	)	)	PUNCT
admet-628	504	5	883	883	NUM
admet-628	504	6	-	-	PUNCT
admet-628	504	7	908	908	NUM
admet-628	504	8	.	.	PUNCT
admet-628	505	1	[	[	X
admet-628	505	2	23	23	NUM
admet-628	505	3	]	]	X
admet-628	505	4	q.	q.	PROPN
admet-628	505	5	chang	chang	PROPN
admet-628	505	6	,	,	PUNCT
admet-628	505	7	m.s.s	m.s.s	PROPN
admet-628	505	8	chow	chow	PROPN
admet-628	505	9	,	,	PUNCT
admet-628	505	10	z.	z.	PROPN
admet-628	505	11	zuo	zuo	PROPN
admet-628	505	12	.	.	PUNCT
admet-628	506	1	studies	study	NOUN
admet-628	506	2	on	on	ADP
admet-628	506	3	the	the	DET
admet-628	506	4	influence	influence	NOUN
admet-628	506	5	of	of	ADP
admet-628	506	6	esterase	esterase	NOUN
admet-628	506	7	inhibitor	inhibitor	NOUN
admet-628	506	8	to	to	ADP
admet-628	506	9	the	the	DET
admet-628	506	10	pharmacokinetic	pharmacokinetic	ADJ
admet-628	506	11	profiles	profile	NOUN
admet-628	506	12	of	of	ADP
admet-628	506	13	oseltamivir	oseltamivir	PROPN
admet-628	506	14	and	and	CCONJ
admet-628	506	15	oseltamivir	oseltamivir	PROPN
admet-628	506	16	carboxylate	carboxylate	VERB
admet-628	506	17	in	in	ADP
admet-628	506	18	rats	rat	NOUN
admet-628	506	19	using	use	VERB
admet-628	506	20	an	an	DET
admet-628	506	21	improved	improved	ADJ
admet-628	506	22	lc	lc	PROPN
admet-628	506	23	/	/	SYM
admet-628	506	24	ms	ms	PROPN
admet-628	506	25	/	/	SYM
admet-628	506	26	ms	ms	PROPN
admet-628	506	27	method	method	NOUN
admet-628	506	28	.	.	PUNCT
admet-628	507	1	biomed	biome	VERB
admet-628	507	2	.	.	PUNCT
admet-628	508	1	chromatogr	chromatogr	PROPN
admet-628	508	2	.	.	PUNCT
admet-628	509	1	23	23	NUM
admet-628	509	2	(	(	PUNCT
admet-628	509	3	2009	2009	NUM
admet-628	509	4	)	)	PUNCT
admet-628	509	5	852	852	NUM
admet-628	509	6	-	-	SYM
admet-628	509	7	857	857	NUM
admet-628	509	8	.	.	PUNCT
admet-628	510	1	g.	g.	PROPN
admet-628	510	2	gao	gao	PROPN
admet-628	510	3	et	et	PROPN
admet-628	510	4	al	al	PROPN
admet-628	510	5	.	.	PROPN
admet-628	510	6	admet	admet	PROPN
admet-628	510	7	&	&	CCONJ
admet-628	510	8	dmpk	dmpk	PROPN
admet-628	510	9	7(1	7(1	PROPN
admet-628	510	10	)	)	PUNCT
admet-628	510	11	(	(	PUNCT
admet-628	510	12	2019	2019	NUM
admet-628	510	13	)	)	PUNCT
admet-628	510	14	22	22	NUM
admet-628	510	15	-	-	SYM
admet-628	510	16	43	43	NUM
admet-628	510	17	40	40	NUM
admet-628	511	1	[	[	X
admet-628	511	2	24	24	NUM
admet-628	511	3	]	]	X
admet-628	511	4	n.	n.	NOUN
admet-628	511	5	lindegardh	lindegardh	PROPN
admet-628	511	6	,	,	PUNCT
admet-628	511	7	w.	w.	PROPN
admet-628	511	8	hanpithakpong	hanpithakpong	PROPN
admet-628	511	9	,	,	PUNCT
admet-628	511	10	y.	y.	PROPN
admet-628	511	11	wattanagoon	wattanagoon	PROPN
admet-628	511	12	,	,	PUNCT
admet-628	511	13	p.	p.	PROPN
admet-628	511	14	singhasivanon	singhasivanon	NOUN
admet-628	511	15	,	,	PUNCT
admet-628	511	16	n.j	n.j	PROPN
admet-628	511	17	.	.	PROPN
admet-628	511	18	white	white	PROPN
admet-628	511	19	,	,	PUNCT
admet-628	511	20	n.p.j	n.p.j	NOUN
admet-628	511	21	.	.	PUNCT
admet-628	511	22	day	day	NOUN
admet-628	511	23	.	.	PUNCT
admet-628	512	1	development	development	NOUN
admet-628	512	2	and	and	CCONJ
admet-628	512	3	validation	validation	NOUN
admet-628	512	4	of	of	ADP
admet-628	512	5	a	a	DET
admet-628	512	6	liquid	liquid	ADJ
admet-628	512	7	chromatographic	chromatographic	ADJ
admet-628	512	8	-	-	PUNCT
admet-628	512	9	tandem	tandem	NOUN
admet-628	512	10	mass	mass	ADJ
admet-628	512	11	spectrometric	spectrometric	ADJ
admet-628	512	12	method	method	NOUN
admet-628	512	13	for	for	ADP
admet-628	512	14	determination	determination	NOUN
admet-628	512	15	of	of	ADP
admet-628	512	16	oseltamivir	oseltamivir	PROPN
admet-628	512	17	and	and	CCONJ
admet-628	512	18	its	its	PRON
admet-628	512	19	metabolite	metabolite	NOUN
admet-628	512	20	oseltamivir	oseltamivir	PROPN
admet-628	512	21	carboxylate	carboxylate	VERB
admet-628	512	22	in	in	ADP
admet-628	512	23	plasma	plasma	NOUN
admet-628	512	24	,	,	PUNCT
admet-628	512	25	saliva	saliva	NOUN
admet-628	512	26	and	and	CCONJ
admet-628	512	27	urine	urine	NOUN
admet-628	512	28	.	.	PUNCT
admet-628	513	1	j.	j.	PROPN
admet-628	513	2	chromatogr	chromatogr	PROPN
admet-628	513	3	.	.	PUNCT
admet-628	514	1	b	b	ADP
admet-628	514	2	859	859	NUM
admet-628	514	3	(	(	PUNCT
admet-628	514	4	2007	2007	NUM
admet-628	514	5	)	)	PUNCT
admet-628	514	6	74	74	NUM
admet-628	514	7	-	-	SYM
admet-628	514	8	83	83	NUM
admet-628	514	9	.	.	PUNCT
admet-628	515	1	[	[	X
admet-628	515	2	25	25	NUM
admet-628	515	3	]	]	X
admet-628	515	4	o.	o.	PROPN
admet-628	515	5	luttringer	luttringer	PROPN
admet-628	515	6	,	,	PUNCT
admet-628	515	7	f.p	f.p	PROPN
admet-628	515	8	.	.	PROPN
admet-628	515	9	theil	theil	PROPN
admet-628	515	10	,	,	PUNCT
admet-628	515	11	p.	p.	PROPN
admet-628	515	12	poulin	poulin	PROPN
admet-628	515	13	,	,	PUNCT
admet-628	515	14	a.h	a.h	PROPN
admet-628	515	15	.	.	PROPN
admet-628	515	16	schmitt	schmitt	PROPN
admet-628	515	17	-	-	PUNCT
admet-628	515	18	hoffmann	hoffmann	PROPN
admet-628	515	19	,	,	PUNCT
admet-628	515	20	t.w	t.w	PROPN
admet-628	515	21	.	.	PROPN
admet-628	515	22	guentert	guentert	PROPN
admet-628	515	23	,	,	PUNCT
admet-628	515	24	t.	t.	PROPN
admet-628	515	25	lave	lave	PROPN
admet-628	515	26	.	.	PUNCT
admet-628	516	1	physiologicallybased	physiologicallybased	ADJ
admet-628	516	2	pharmacokinetic	pharmacokinetic	ADJ
admet-628	516	3	(	(	PUNCT
admet-628	516	4	pbpk	pbpk	NOUN
admet-628	516	5	)	)	PUNCT
admet-628	516	6	modeling	modeling	NOUN
admet-628	516	7	of	of	ADP
admet-628	516	8	disposition	disposition	NOUN
admet-628	516	9	of	of	ADP
admet-628	516	10	epiroprim	epiroprim	NOUN
admet-628	516	11	in	in	ADP
admet-628	516	12	humans	human	NOUN
admet-628	516	13	.	.	PUNCT
admet-628	517	1	j.	j.	PROPN
admet-628	517	2	pharm	pharm	PROPN
admet-628	517	3	.	.	PUNCT
admet-628	518	1	sci	sci	PROPN
admet-628	518	2	.	.	PROPN
admet-628	519	1	92	92	NUM
admet-628	519	2	(	(	PUNCT
admet-628	519	3	2003	2003	NUM
admet-628	519	4	)	)	PUNCT
admet-628	519	5	1990	1990	NUM
admet-628	519	6	-	-	SYM
admet-628	519	7	2007	2007	NUM
admet-628	519	8	.	.	PUNCT
admet-628	520	1	[	[	X
admet-628	520	2	26	26	NUM
admet-628	520	3	]	]	X
admet-628	520	4	b.	b.	PROPN
admet-628	520	5	davies	davy	NOUN
admet-628	520	6	,	,	PUNCT
admet-628	520	7	t.	t.	PROPN
admet-628	520	8	morris	morris	PROPN
admet-628	520	9	.	.	PROPN
admet-628	520	10	physiological	physiological	ADJ
admet-628	520	11	parameters	parameter	NOUN
admet-628	520	12	in	in	ADP
admet-628	520	13	laboratory	laboratory	NOUN
admet-628	520	14	animals	animal	NOUN
admet-628	520	15	and	and	CCONJ
admet-628	520	16	humans	human	NOUN
admet-628	520	17	.	.	PUNCT
admet-628	521	1	pharm	pharm	NOUN
admet-628	521	2	.	.	PUNCT
admet-628	522	1	res	re	NOUN
admet-628	522	2	.	.	PROPN
admet-628	523	1	10	10	NUM
admet-628	523	2	(	(	PUNCT
admet-628	523	3	1993	1993	NUM
admet-628	523	4	)	)	PUNCT
admet-628	523	5	1093	1093	NUM
admet-628	523	6	-	-	SYM
admet-628	523	7	1095	1095	NUM
admet-628	523	8	.	.	PUNCT
admet-628	524	1	[	[	X
admet-628	524	2	27	27	NUM
admet-628	524	3	]	]	X
admet-628	524	4	m.j	m.j	PROPN
admet-628	524	5	.	.	PROPN
admet-628	524	6	angelo	angelo	PROPN
admet-628	524	7	,	,	PUNCT
admet-628	524	8	a.b	a.b	PROPN
admet-628	524	9	.	.	PROPN
admet-628	524	10	pritchard	pritchard	PROPN
admet-628	524	11	.	.	PUNCT
admet-628	525	1	route	route	NOUN
admet-628	525	2	-	-	PUNCT
admet-628	525	3	to	to	ADP
admet-628	525	4	-	-	PUNCT
admet-628	525	5	route	route	NOUN
admet-628	525	6	extrapolation	extrapolation	NOUN
admet-628	525	7	of	of	ADP
admet-628	525	8	dichloromethane	dichloromethane	NOUN
admet-628	525	9	exposure	exposure	NOUN
admet-628	525	10	using	use	VERB
admet-628	525	11	a	a	DET
admet-628	525	12	physiological	physiological	ADJ
admet-628	525	13	pharmacokinetic	pharmacokinetic	ADJ
admet-628	525	14	model	model	NOUN
admet-628	525	15	.	.	PUNCT
admet-628	526	1	in	in	ADP
admet-628	526	2	:	:	PUNCT
admet-628	526	3	pharmacokinetics	pharmacokinetic	NOUN
admet-628	526	4	and	and	CCONJ
admet-628	526	5	in	in	ADP
admet-628	526	6	risk	risk	NOUN
admet-628	526	7	assessment	assessment	NOUN
admet-628	526	8	:	:	PUNCT
admet-628	526	9	drinking	drink	VERB
admet-628	526	10	water	water	NOUN
admet-628	526	11	and	and	CCONJ
admet-628	526	12	health	health	NOUN
admet-628	526	13	.	.	PUNCT
admet-628	527	1	national	national	PROPN
admet-628	527	2	academy	academy	PROPN
admet-628	527	3	press	press	PROPN
admet-628	527	4	,	,	PUNCT
admet-628	527	5	1987	1987	NUM
admet-628	527	6	pp	pp	ADP
admet-628	527	7	254	254	NUM
admet-628	527	8	-	-	SYM
admet-628	527	9	264	264	NUM
admet-628	527	10	,	,	PUNCT
admet-628	527	11	washington	washington	PROPN
admet-628	527	12	,	,	PUNCT
admet-628	527	13	dc	dc	PROPN
admet-628	527	14	.	.	PUNCT
admet-628	528	1	[	[	X
admet-628	528	2	28	28	NUM
admet-628	528	3	]	]	X
admet-628	528	4	m.j	m.j	PROPN
admet-628	528	5	.	.	PROPN
admet-628	528	6	anderton	anderton	PROPN
admet-628	528	7	,	,	PUNCT
admet-628	528	8	m.m	m.m	PROPN
admet-628	528	9	.	.	PROPN
admet-628	528	10	manson	manson	PROPN
admet-628	528	11	,	,	PUNCT
admet-628	528	12	r.	r.	PROPN
admet-628	528	13	verschoyle	verschoyle	PROPN
admet-628	528	14	,	,	PUNCT
admet-628	528	15	a.	a.	NOUN
admet-628	528	16	gescher	gescher	PROPN
admet-628	528	17	,	,	PUNCT
admet-628	528	18	w.p	w.p	PROPN
admet-628	528	19	.	.	PROPN
admet-628	528	20	steward	steward	PROPN
admet-628	528	21	,	,	PUNCT
admet-628	528	22	m.l.williams	m.l.william	NOUN
admet-628	528	23	,	,	PUNCT
admet-628	528	24	d.e	d.e	PROPN
admet-628	528	25	.	.	PROPN
admet-628	528	26	mager	mager	PROPN
admet-628	528	27	.	.	PUNCT
admet-628	529	1	physiological	physiological	ADJ
admet-628	529	2	modeling	modeling	NOUN
admet-628	529	3	of	of	ADP
admet-628	529	4	formulated	formulated	ADJ
admet-628	529	5	and	and	CCONJ
admet-628	529	6	crystalline	crystalline	ADJ
admet-628	529	7	3,3’-diindolylmethane	3,3’-diindolylmethane	NOUN
admet-628	529	8	pharmacokinetics	pharmacokinetic	NOUN
admet-628	529	9	following	follow	VERB
admet-628	529	10	oral	oral	ADJ
admet-628	529	11	administration	administration	NOUN
admet-628	529	12	in	in	ADP
admet-628	529	13	mice	mouse	NOUN
admet-628	529	14	.	.	PUNCT
admet-628	530	1	drug	drug	NOUN
admet-628	530	2	metab	metab	NOUN
admet-628	530	3	.	.	PUNCT
admet-628	531	1	dispos	dispos	PROPN
admet-628	531	2	.	.	PUNCT
admet-628	532	1	32	32	NUM
admet-628	532	2	(	(	PUNCT
admet-628	532	3	2004	2004	NUM
admet-628	532	4	)	)	PUNCT
admet-628	533	1	632–638	632–638	NUM
admet-628	533	2	.	.	PUNCT
admet-628	534	1	[	[	X
admet-628	534	2	29	29	NUM
admet-628	534	3	]	]	X
admet-628	534	4	j.m	j.m	PROPN
admet-628	534	5	.	.	PROPN
admet-628	534	6	gallo	gallo	PROPN
admet-628	534	7	,	,	PUNCT
admet-628	534	8	f.c	f.c	PROPN
admet-628	534	9	.	.	PROPN
admet-628	534	10	lam	lam	PROPN
admet-628	534	11	,	,	PUNCT
admet-628	534	12	d.g	d.g	PROPN
admet-628	534	13	.	.	PROPN
admet-628	534	14	perrier	perrier	PROPN
admet-628	534	15	.	.	PUNCT
admet-628	535	1	area	area	NOUN
admet-628	535	2	method	method	NOUN
admet-628	535	3	for	for	ADP
admet-628	535	4	the	the	DET
admet-628	535	5	estimation	estimation	NOUN
admet-628	535	6	of	of	ADP
admet-628	535	7	partition	partition	NOUN
admet-628	535	8	coefficients	coefficient	NOUN
admet-628	535	9	for	for	ADP
admet-628	535	10	physiological	physiological	ADJ
admet-628	535	11	pharmacokinetic	pharmacokinetic	ADJ
admet-628	535	12	models	model	NOUN
admet-628	535	13	.	.	PUNCT
admet-628	536	1	j.	j.	PROPN
admet-628	536	2	pharmacokinet	pharmacokinet	PROPN
admet-628	536	3	.	.	PUNCT
admet-628	537	1	biopharm	biopharm	PROPN
admet-628	537	2	.	.	PUNCT
admet-628	538	1	15	15	NUM
admet-628	538	2	(	(	PUNCT
admet-628	538	3	1987	1987	NUM
admet-628	538	4	)	)	PUNCT
admet-628	538	5	271	271	NUM
admet-628	538	6	-	-	SYM
admet-628	538	7	280	280	NUM
admet-628	538	8	.	.	PUNCT
admet-628	539	1	[	[	X
admet-628	539	2	30	30	NUM
admet-628	539	3	]	]	PUNCT
admet-628	539	4	z.	z.	PROPN
admet-628	539	5	ye	ye	PROPN
admet-628	539	6	,	,	PUNCT
admet-628	539	7	h.	h.	PROPN
admet-628	539	8	gao	gao	PROPN
admet-628	539	9	,	,	PUNCT
admet-628	539	10	approaches	approach	VERB
admet-628	539	11	to	to	PART
admet-628	539	12	measure	measure	VERB
admet-628	539	13	protein	protein	NOUN
admet-628	539	14	binding	bind	VERB
admet-628	539	15	of	of	ADP
admet-628	539	16	enzymatically	enzymatically	ADV
admet-628	539	17	unstable	unstable	ADJ
admet-628	539	18	compounds	compound	NOUN
admet-628	539	19	in	in	ADP
admet-628	539	20	plasma	plasma	NOUN
admet-628	539	21	,	,	PUNCT
admet-628	539	22	bioanalysis	bioanalysis	NOUN
admet-628	539	23	10	10	NUM
admet-628	539	24	(	(	PUNCT
admet-628	539	25	2018	2018	NUM
admet-628	539	26	)	)	PUNCT
admet-628	539	27	451	451	NUM
admet-628	539	28	-	-	SYM
admet-628	539	29	459	459	NUM
admet-628	539	30	.	.	PUNCT
admet-628	540	1	[	[	X
admet-628	540	2	31	31	NUM
admet-628	540	3	]	]	X
admet-628	540	4	k.b	k.b	PROPN
admet-628	540	5	.	.	PROPN
admet-628	540	6	bischoff	bischoff	PROPN
admet-628	540	7	,	,	PUNCT
admet-628	540	8	r.l	r.l	PROPN
admet-628	540	9	.	.	PROPN
admet-628	540	10	dedrick	dedrick	PROPN
admet-628	540	11	,	,	PUNCT
admet-628	540	12	d.s	d.s	PROPN
admet-628	540	13	.	.	PROPN
admet-628	540	14	zaharko	zaharko	PROPN
admet-628	540	15	,	,	PUNCT
admet-628	540	16	j.a	j.a	PROPN
admet-628	540	17	.	.	PROPN
admet-628	540	18	longstreth	longstreth	PROPN
admet-628	540	19	.	.	PROPN
admet-628	541	1	methotrexate	methotrexate	PROPN
admet-628	541	2	pharmacokinetics	pharmacokinetic	NOUN
admet-628	541	3	.	.	PUNCT
admet-628	542	1	j.	j.	PROPN
admet-628	542	2	pharm	pharm	PROPN
admet-628	542	3	.	.	PUNCT
admet-628	543	1	sci	sci	PROPN
admet-628	543	2	.	.	PROPN
admet-628	544	1	60	60	NUM
admet-628	544	2	(	(	PUNCT
admet-628	544	3	1971	1971	NUM
admet-628	544	4	)	)	PUNCT
admet-628	544	5	1128	1128	NUM
admet-628	544	6	-	-	SYM
admet-628	544	7	1133	1133	NUM
admet-628	544	8	.	.	PUNCT
admet-628	545	1	[	[	X
admet-628	545	2	32	32	NUM
admet-628	545	3	]	]	X
admet-628	545	4	b.e	b.e	PROPN
admet-628	545	5	.	.	PROPN
admet-628	545	6	davies	davy	NOUN
admet-628	545	7	.	.	PUNCT
admet-628	546	1	pharmacokinetics	pharmacokinetic	NOUN
admet-628	546	2	of	of	ADP
admet-628	546	3	oseltamivir	oseltamivir	NOUN
admet-628	546	4	:	:	PUNCT
admet-628	546	5	an	an	DET
admet-628	546	6	oral	oral	ADJ
admet-628	546	7	antiviral	antiviral	NOUN
admet-628	546	8	for	for	ADP
admet-628	546	9	the	the	DET
admet-628	546	10	treatment	treatment	NOUN
admet-628	546	11	and	and	CCONJ
admet-628	546	12	prophylaxis	prophylaxis	NOUN
admet-628	546	13	of	of	ADP
admet-628	546	14	influenza	influenza	NOUN
admet-628	546	15	in	in	ADP
admet-628	546	16	diverse	diverse	ADJ
admet-628	546	17	populations	population	NOUN
admet-628	546	18	.	.	PUNCT
admet-628	547	1	j.	j.	PROPN
admet-628	547	2	antimicrob	antimicrob	PROPN
admet-628	547	3	.	.	PUNCT
admet-628	548	1	chemother	chemother	PROPN
admet-628	548	2	.	.	PUNCT
admet-628	549	1	65	65	NUM
admet-628	549	2	(	(	PUNCT
admet-628	549	3	suppl	suppl	ADJ
admet-628	549	4	.	.	PROPN
admet-628	549	5	2	2	NUM
admet-628	549	6	)	)	PUNCT
admet-628	549	7	(	(	PUNCT
admet-628	549	8	2010	2010	NUM
admet-628	549	9	)	)	PUNCT
admet-628	549	10	ii5	ii5	PROPN
admet-628	549	11	-	-	PUNCT
admet-628	549	12	ii10	ii10	PROPN
admet-628	549	13	.	.	PUNCT
admet-628	550	1	[	[	X
admet-628	550	2	33	33	NUM
admet-628	550	3	]	]	PUNCT
admet-628	550	4	s.	s.	PROPN
admet-628	550	5	lennon	lennon	PROPN
admet-628	550	6	,	,	PUNCT
admet-628	550	7	j.	j.	PROPN
admet-628	550	8	barrett	barrett	PROPN
admet-628	550	9	,	,	PUNCT
admet-628	550	10	c.	c.	PROPN
admet-628	550	11	kirkpatrick	kirkpatrick	PROPN
admet-628	550	12	,	,	PUNCT
admet-628	550	13	c.	c.	PROPN
admet-628	550	14	rayner	rayner	PROPN
admet-628	550	15	.	.	PUNCT
admet-628	551	1	oseltamivir	oseltamivir	PROPN
admet-628	551	2	oral	oral	ADJ
admet-628	551	3	suspension	suspension	NOUN
admet-628	551	4	and	and	CCONJ
admet-628	551	5	capsules	capsule	NOUN
admet-628	551	6	are	be	AUX
admet-628	551	7	bioequivalent	bioequivalent	NOUN
admet-628	551	8	for	for	ADP
admet-628	551	9	the	the	DET
admet-628	551	10	active	active	ADJ
admet-628	551	11	metabolite	metabolite	NOUN
admet-628	551	12	in	in	ADP
admet-628	551	13	healthy	healthy	ADJ
admet-628	551	14	adult	adult	NOUN
admet-628	551	15	volunteers	volunteer	NOUN
admet-628	551	16	.	.	PUNCT
admet-628	552	1	int	int	NOUN
admet-628	552	2	.	.	PUNCT
admet-628	553	1	j.	j.	PROPN
admet-628	553	2	clin	clin	PROPN
admet-628	553	3	.	.	PUNCT
admet-628	554	1	pharmacol	pharmacol	PROPN
admet-628	554	2	.	.	PUNCT
admet-628	555	1	ther	ther	PROPN
admet-628	555	2	.	.	PUNCT
admet-628	556	1	47	47	NUM
admet-628	556	2	(	(	PUNCT
admet-628	556	3	2009	2009	NUM
admet-628	556	4	)	)	PUNCT
admet-628	556	5	539	539	NUM
admet-628	556	6	-	-	SYM
admet-628	556	7	549	549	NUM
admet-628	556	8	.	.	PUNCT
admet-628	557	1	[	[	X
admet-628	557	2	34	34	NUM
admet-628	557	3	]	]	X
admet-628	557	4	w.l	w.l	PROPN
admet-628	557	5	.	.	PROPN
admet-628	557	6	chiou	chiou	PROPN
admet-628	557	7	,	,	PUNCT
admet-628	557	8	g.	g.	PROPN
admet-628	557	9	robbie	robbie	PROPN
admet-628	557	10	,	,	PUNCT
admet-628	557	11	s.m	s.m	PROPN
admet-628	557	12	.	.	PROPN
admet-628	557	13	chung	chung	PROPN
admet-628	557	14	,	,	PUNCT
admet-628	557	15	t.c	t.c	PROPN
admet-628	557	16	.	.	PROPN
admet-628	557	17	wu	wu	PROPN
admet-628	557	18	,	,	PUNCT
admet-628	557	19	c.	c.	PROPN
admet-628	557	20	ma	ma	PROPN
admet-628	557	21	.	.	PROPN
admet-628	557	22	correlation	correlation	NOUN
admet-628	557	23	of	of	ADP
admet-628	557	24	plasma	plasma	NOUN
admet-628	557	25	clearance	clearance	NOUN
admet-628	557	26	of	of	ADP
admet-628	557	27	54	54	NUM
admet-628	557	28	extensively	extensively	ADV
admet-628	557	29	metabolized	metabolize	VERB
admet-628	557	30	drugs	drug	NOUN
admet-628	557	31	between	between	ADP
admet-628	557	32	humans	human	NOUN
admet-628	557	33	and	and	CCONJ
admet-628	557	34	rats	rat	NOUN
admet-628	557	35	:	:	PUNCT
admet-628	557	36	mean	mean	VERB
admet-628	557	37	allometric	allometric	ADJ
admet-628	557	38	coefficient	coefficient	NOUN
admet-628	557	39	of	of	ADP
admet-628	557	40	0.66	0.66	NUM
admet-628	557	41	.	.	PUNCT
admet-628	558	1	pharm	pharm	NOUN
admet-628	558	2	.	.	PUNCT
admet-628	559	1	res	re	NOUN
admet-628	559	2	.	.	PROPN
admet-628	560	1	15	15	NUM
admet-628	560	2	(	(	PUNCT
admet-628	560	3	1998	1998	NUM
admet-628	560	4	)	)	PUNCT
admet-628	560	5	1474	1474	NUM
admet-628	560	6	-	-	SYM
admet-628	560	7	1479	1479	NUM
admet-628	560	8	.	.	PUNCT
admet-628	561	1	[	[	X
admet-628	561	2	35	35	NUM
admet-628	561	3	]	]	X
admet-628	561	4	t.	t.	PROPN
admet-628	561	5	iwatsubo	iwatsubo	PROPN
admet-628	561	6	,	,	PUNCT
admet-628	561	7	n.	n.	PROPN
admet-628	561	8	hirota	hirota	PROPN
admet-628	561	9	,	,	PUNCT
admet-628	561	10	t.	t.	NOUN
admet-628	561	11	ooie	ooie	PROPN
admet-628	561	12	,	,	PUNCT
admet-628	561	13	h.	h.	PROPN
admet-628	561	14	suzuki	suzuki	PROPN
admet-628	561	15	,	,	PUNCT
admet-628	561	16	n.	n.	PROPN
admet-628	561	17	shimada	shimada	PROPN
admet-628	561	18	,	,	PUNCT
admet-628	561	19	k.	k.	PROPN
admet-628	561	20	chiba	chiba	PROPN
admet-628	561	21	,	,	PUNCT
admet-628	561	22	t.	t.	PROPN
admet-628	561	23	ishizaki	ishizaki	PROPN
admet-628	561	24	,	,	PUNCT
admet-628	561	25	c.e	c.e	PROPN
admet-628	561	26	.	.	PROPN
admet-628	561	27	green	green	PROPN
admet-628	561	28	,	,	PUNCT
admet-628	561	29	c.a	c.a	PROPN
admet-628	561	30	.	.	PROPN
admet-628	561	31	tyson	tyson	PROPN
admet-628	561	32	,	,	PUNCT
admet-628	561	33	y.	y.	PROPN
admet-628	561	34	sugiyama	sugiyama	PROPN
admet-628	561	35	.	.	PUNCT
admet-628	562	1	prediction	prediction	NOUN
admet-628	562	2	of	of	ADP
admet-628	562	3	in	in	ADP
admet-628	562	4	vivo	vivo	ADJ
admet-628	562	5	drug	drug	NOUN
admet-628	562	6	metabolism	metabolism	NOUN
admet-628	562	7	in	in	ADP
admet-628	562	8	the	the	DET
admet-628	562	9	human	human	ADJ
admet-628	562	10	liver	liver	NOUN
admet-628	562	11	from	from	ADP
admet-628	562	12	in	in	ADP
admet-628	562	13	vitro	vitro	X
admet-628	562	14	metabolism	metabolism	NOUN
admet-628	562	15	data	datum	NOUN
admet-628	562	16	.	.	PUNCT
admet-628	563	1	pharmacol	pharmacol	PROPN
admet-628	563	2	.	.	PUNCT
admet-628	564	1	ther	ther	PROPN
admet-628	564	2	.	.	PUNCT
admet-628	565	1	73	73	NUM
admet-628	565	2	(	(	PUNCT
admet-628	565	3	1997	1997	NUM
admet-628	565	4	)	)	PUNCT
admet-628	565	5	147	147	NUM
admet-628	565	6	-	-	SYM
admet-628	565	7	171	171	NUM
admet-628	565	8	.	.	PUNCT
admet-628	566	1	[	[	X
admet-628	566	2	36	36	NUM
admet-628	566	3	]	]	X
admet-628	566	4	c.c	c.c	PROPN
admet-628	566	5	.	.	PROPN
admet-628	566	6	travis	travis	PROPN
admet-628	566	7	.	.	PUNCT
admet-628	566	8	interspecies	interspecie	NOUN
admet-628	566	9	and	and	CCONJ
admet-628	566	10	dose	dose	NOUN
admet-628	566	11	-	-	PUNCT
admet-628	566	12	route	route	NOUN
admet-628	566	13	extrapolations	extrapolation	NOUN
admet-628	566	14	,	,	PUNCT
admet-628	566	15	in	in	ADP
admet-628	566	16	:	:	PUNCT
admet-628	566	17	pharmacokinetics	pharmacokinetic	NOUN
admet-628	566	18	in	in	ADP
admet-628	566	19	risk	risk	NOUN
admet-628	566	20	assessment	assessment	NOUN
admet-628	566	21	:	:	PUNCT
admet-628	566	22	drinking	drink	VERB
admet-628	566	23	water	water	NOUN
admet-628	566	24	and	and	CCONJ
admet-628	566	25	health	health	NOUN
admet-628	566	26	,	,	PUNCT
admet-628	566	27	vol	vol	NOUN
admet-628	566	28	.	.	PROPN
admet-628	566	29	8	8	NUM
admet-628	566	30	.	.	PUNCT
admet-628	566	31	national	national	PROPN
admet-628	566	32	academy	academy	PROPN
admet-628	566	33	press	press	PROPN
admet-628	566	34	,	,	PUNCT
admet-628	566	35	1987	1987	NUM
admet-628	566	36	,	,	PUNCT
admet-628	566	37	washington	washington	PROPN
admet-628	566	38	,	,	PUNCT
admet-628	566	39	d.c	d.c	PROPN
admet-628	566	40	.	.	PUNCT
admet-628	567	1	[	[	X
admet-628	567	2	37	37	NUM
admet-628	567	3	]	]	X
admet-628	567	4	f.j	f.j	PROPN
admet-628	567	5	.	.	PUNCT
admet-628	567	6	eisenberg	eisenberg	PROPN
admet-628	567	7	,	,	PUNCT
admet-628	567	8	a.	a.	NOUN
admet-628	567	9	bidgood	bidgood	PROPN
admet-628	567	10	,	,	PUNCT
admet-628	567	11	k.c	k.c	PROPN
admet-628	567	12	.	.	PROPN
admet-628	567	13	cundy	cundy	PROPN
admet-628	567	14	.	.	PUNCT
admet-628	568	1	penetration	penetration	NOUN
admet-628	568	2	of	of	ADP
admet-628	568	3	gs	gs	PROPN
admet-628	568	4	4071	4071	NUM
admet-628	568	5	,	,	PUNCT
admet-628	568	6	a	a	DET
admet-628	568	7	novel	novel	ADJ
admet-628	568	8	influenza	influenza	ADJ
admet-628	568	9	neuraminidase	neuraminidase	NOUN
admet-628	568	10	inhibitor	inhibitor	NOUN
admet-628	568	11	into	into	ADP
admet-628	568	12	rat	rat	NOUN
admet-628	568	13	bronchoalveolar	bronchoalveolar	ADJ
admet-628	568	14	lining	lining	NOUN
admet-628	568	15	fluid	fluid	NOUN
admet-628	568	16	following	follow	VERB
admet-628	568	17	oral	oral	ADJ
admet-628	568	18	administration	administration	NOUN
admet-628	568	19	of	of	ADP
admet-628	568	20	the	the	DET
admet-628	568	21	prodrug	prodrug	NOUN
admet-628	568	22	gs	gs	ADP
admet-628	568	23	4104	4104	NUM
admet-628	568	24	.	.	PUNCT
admet-628	569	1	antimicrob	antimicrob	PROPN
admet-628	569	2	.	.	PUNCT
admet-628	570	1	agents	agent	NOUN
admet-628	570	2	chemother	chemother	PROPN
admet-628	570	3	.	.	PUNCT
admet-628	571	1	41	41	NUM
admet-628	571	2	(	(	PUNCT
admet-628	571	3	1997	1997	NUM
admet-628	571	4	)	)	PUNCT
admet-628	571	5	1949	1949	NUM
admet-628	571	6	-	-	SYM
admet-628	571	7	1952	1952	NUM
admet-628	571	8	.	.	PUNCT
admet-628	572	1	[	[	X
admet-628	572	2	38	38	NUM
admet-628	572	3	]	]	PUNCT
admet-628	572	4	s.	s.	PROPN
admet-628	572	5	bjorkman	bjorkman	PROPN
admet-628	572	6	,	,	PUNCT
admet-628	572	7	d.r	d.r	PROPN
admet-628	572	8	.	.	PROPN
admet-628	572	9	wada	wada	PROPN
admet-628	572	10	,	,	PUNCT
admet-628	572	11	d.r	d.r	PROPN
admet-628	572	12	.	.	PROPN
admet-628	572	13	stanski	stanski	PROPN
admet-628	572	14	,	,	PUNCT
admet-628	572	15	w.f	w.f	PROPN
admet-628	572	16	.	.	NOUN
admet-628	572	17	ebling	eble	VERB
admet-628	572	18	.	.	PUNCT
admet-628	573	1	comparative	comparative	ADJ
admet-628	573	2	physiological	physiological	ADJ
admet-628	573	3	pharmacokinetics	pharmacokinetic	NOUN
admet-628	573	4	of	of	ADP
admet-628	573	5	fentanyl	fentanyl	NOUN
admet-628	573	6	and	and	CCONJ
admet-628	573	7	alfentanil	alfentanil	ADJ
admet-628	573	8	in	in	ADP
admet-628	573	9	rats	rat	NOUN
admet-628	573	10	and	and	CCONJ
admet-628	573	11	humans	human	NOUN
admet-628	573	12	based	base	VERB
admet-628	573	13	on	on	ADP
admet-628	573	14	parametric	parametric	ADJ
admet-628	573	15	single	single	ADJ
admet-628	573	16	-	-	PUNCT
admet-628	573	17	tissue	tissue	NOUN
admet-628	573	18	models	model	NOUN
admet-628	573	19	.	.	PUNCT
admet-628	574	1	j.	j.	PROPN
admet-628	574	2	pharmacokinet	pharmacokinet	PROPN
admet-628	574	3	.	.	PUNCT
admet-628	574	4	biopharmaceut	biopharmaceut	PROPN
admet-628	574	5	.	.	PUNCT
admet-628	575	1	22	22	NUM
admet-628	575	2	(	(	PUNCT
admet-628	575	3	1994	1994	NUM
admet-628	575	4	)	)	PUNCT
admet-628	575	5	381410	381410	NUM
admet-628	575	6	.	.	PUNCT
admet-628	576	1	[	[	X
admet-628	576	2	39	39	NUM
admet-628	576	3	]	]	X
admet-628	576	4	h.j	h.j	PROPN
admet-628	576	5	.	.	PROPN
admet-628	576	6	clewell	clewell	PROPN
admet-628	576	7	,	,	PUNCT
admet-628	576	8	t.s	t.s	PROPN
admet-628	576	9	.	.	PROPN
admet-628	576	10	lee	lee	PROPN
admet-628	576	11	,	,	PUNCT
admet-628	576	12	r.l	r.l	PROPN
admet-628	576	13	.	.	PROPN
admet-628	576	14	carpenter	carpenter	PROPN
admet-628	576	15	.	.	PUNCT
admet-628	577	1	sensitivity	sensitivity	NOUN
admet-628	577	2	of	of	ADP
admet-628	577	3	physiologically	physiologically	ADV
admet-628	577	4	based	base	VERB
admet-628	577	5	pharmacokinetic	pharmacokinetic	ADJ
admet-628	577	6	models	model	NOUN
admet-628	577	7	to	to	ADP
admet-628	577	8	variation	variation	NOUN
admet-628	577	9	in	in	ADP
admet-628	577	10	model	model	NOUN
admet-628	577	11	parameters	parameter	NOUN
admet-628	577	12	:	:	PUNCT
admet-628	577	13	methylene	methylene	ADJ
admet-628	577	14	chloride	chloride	NOUN
admet-628	577	15	.	.	PUNCT
admet-628	578	1	risk	risk	NOUN
admet-628	578	2	anal	anal	NOUN
admet-628	578	3	.	.	PUNCT
admet-628	579	1	14	14	NUM
admet-628	579	2	(	(	PUNCT
admet-628	579	3	1994	1994	NUM
admet-628	579	4	)	)	PUNCT
admet-628	579	5	521	521	NUM
admet-628	579	6	-	-	SYM
admet-628	579	7	531	531	NUM
admet-628	579	8	.	.	PUNCT
admet-628	580	1	[	[	X
admet-628	580	2	40	40	NUM
admet-628	580	3	]	]	PUNCT
admet-628	580	4	g.	g.	PROPN
admet-628	580	5	gao	gao	PROPN
admet-628	580	6	,	,	PUNCT
admet-628	580	7	f.c.p	f.c.p	PROPN
admet-628	580	8	.	.	PROPN
admet-628	580	9	law	law	NOUN
admet-628	580	10	.	.	PUNCT
admet-628	581	1	physiologically	physiologically	ADV
admet-628	581	2	-	-	PUNCT
admet-628	581	3	based	base	VERB
admet-628	581	4	pharmacokinetics	pharmacokinetic	NOUN
admet-628	581	5	of	of	ADP
admet-628	581	6	matrine	matrine	NOUN
admet-628	581	7	in	in	ADP
admet-628	581	8	the	the	DET
admet-628	581	9	rat	rat	NOUN
admet-628	581	10	after	after	ADP
admet-628	581	11	oral	oral	ADJ
admet-628	581	12	administration	administration	NOUN
admet-628	581	13	of	of	ADP
admet-628	581	14	pure	pure	ADJ
admet-628	581	15	chemical	chemical	NOUN
admet-628	581	16	and	and	CCONJ
admet-628	581	17	acapha	acapha	PROPN
admet-628	581	18	.	.	PUNCT
admet-628	582	1	drug	drug	NOUN
admet-628	582	2	metab	metab	NOUN
admet-628	582	3	.	.	PUNCT
admet-628	583	1	dispos	dispos	PROPN
admet-628	583	2	.	.	PUNCT
admet-628	584	1	37	37	NUM
admet-628	584	2	(	(	PUNCT
admet-628	584	3	2009	2009	NUM
admet-628	584	4	)	)	PUNCT
admet-628	584	5	884	884	NUM
admet-628	584	6	-	-	SYM
admet-628	584	7	91	91	NUM
admet-628	584	8	.	.	PUNCT
admet-628	585	1	[	[	X
admet-628	585	2	41	41	NUM
admet-628	585	3	]	]	X
admet-628	585	4	c.y	c.y	PROPN
admet-628	585	5	.	.	PROPN
admet-628	585	6	quon	quon	PROPN
admet-628	585	7	,	,	PUNCT
admet-628	585	8	k.	k.	PROPN
admet-628	585	9	mai	mai	PROPN
admet-628	585	10	,	,	PUNCT
admet-628	585	11	g.	g.	PROPN
admet-628	585	12	patil	patil	PROPN
admet-628	585	13	,	,	PUNCT
admet-628	585	14	h.f	h.f	PROPN
admet-628	585	15	.	.	PROPN
admet-628	585	16	stampfli	stampfli	PROPN
admet-628	585	17	.	.	PUNCT
admet-628	586	1	species	specie	NOUN
admet-628	586	2	differences	difference	NOUN
admet-628	586	3	in	in	ADP
admet-628	586	4	the	the	DET
admet-628	586	5	stereoselective	stereoselective	ADJ
admet-628	586	6	hydrolysis	hydrolysis	NOUN
admet-628	586	7	of	of	ADP
admet-628	586	8	esmolol	esmolol	NOUN
admet-628	586	9	by	by	ADP
admet-628	586	10	blood	blood	NOUN
admet-628	586	11	esterases	esterase	NOUN
admet-628	586	12	.	.	PUNCT
admet-628	587	1	drug	drug	NOUN
admet-628	587	2	metab	metab	NOUN
admet-628	587	3	.	.	PUNCT
admet-628	588	1	dispos	dispos	PROPN
admet-628	588	2	.	.	PUNCT
admet-628	589	1	16	16	NUM
admet-628	589	2	(	(	PUNCT
admet-628	589	3	1988	1988	NUM
admet-628	589	4	)	)	PUNCT
admet-628	589	5	425	425	NUM
admet-628	589	6	-	-	SYM
admet-628	589	7	428	428	NUM
admet-628	589	8	.	.	PUNCT
admet-628	590	1	[	[	X
admet-628	590	2	42	42	NUM
admet-628	590	3	]	]	X
admet-628	590	4	s.s	s.s	PROPN
admet-628	590	5	.	.	PROPN
admet-628	590	6	jhee	jhee	PROPN
admet-628	590	7	,	,	PUNCT
admet-628	590	8	m.	m.	NOUN
admet-628	590	9	yen	yen	PROPN
admet-628	590	10	,	,	PUNCT
admet-628	590	11	l.	l.	PROPN
admet-628	590	12	ereshefsk	ereshefsk	PROPN
admet-628	590	13	.	.	PUNCT
admet-628	591	1	low	low	ADJ
admet-628	591	2	penetration	penetration	NOUN
admet-628	591	3	of	of	ADP
admet-628	591	4	oseltamivir	oseltamivir	PROPN
admet-628	591	5	and	and	CCONJ
admet-628	591	6	its	its	PRON
admet-628	591	7	carbonylate	carbonylate	NOUN
admet-628	591	8	into	into	ADP
admet-628	591	9	cerebrospinal	cerebrospinal	ADJ
admet-628	591	10	fluid	fluid	NOUN
admet-628	591	11	in	in	ADP
admet-628	591	12	healthy	healthy	ADJ
admet-628	591	13	japanese	japanese	ADJ
admet-628	591	14	and	and	CCONJ
admet-628	591	15	caucasian	caucasian	ADJ
admet-628	591	16	volunteers	volunteer	NOUN
admet-628	591	17	.	.	PUNCT
admet-628	592	1	antimicrob	antimicrob	PROPN
admet-628	592	2	.	.	PUNCT
admet-628	593	1	agents	agent	NOUN
admet-628	593	2	chemother	chemother	PROPN
admet-628	593	3	.	.	PUNCT
admet-628	594	1	52	52	NUM
admet-628	594	2	(	(	PUNCT
admet-628	594	3	2008	2008	NUM
admet-628	594	4	)	)	PUNCT
admet-628	594	5	36873693	36873693	NUM
admet-628	594	6	.	.	PUNCT
admet-628	595	1	http://www.ncbi.nlm.nih.gov/pubmed?term=iwatsubo%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=iwatsubo%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	NOUN
admet-628	595	2	http://www.ncbi.nlm.nih.gov/pubmed?term=hirota%20n%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=hirota%20n%5bauthor%5d&cauthor=true&cauthor_uid=9131722	NOUN
admet-628	595	3	http://www.ncbi.nlm.nih.gov/pubmed?term=ooie%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=ooie%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	NOUN
admet-628	595	4	http://www.ncbi.nlm.nih.gov/pubmed?term=suzuki%20h%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=suzuki%20h%5bauthor%5d&cauthor=true&cauthor_uid=9131722	NOUN
admet-628	595	5	http://www.ncbi.nlm.nih.gov/pubmed?term=shimada%20n%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=shimada%20n%5bauthor%5d&cauthor=true&cauthor_uid=9131722	PROPN
admet-628	595	6	http://www.ncbi.nlm.nih.gov/pubmed?term=ishizaki%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	http://www.ncbi.nlm.nih.gov/pubmed?term=ishizaki%20t%5bauthor%5d&cauthor=true&cauthor_uid=9131722	NOUN
admet-628	595	7	admet	admet	PROPN
admet-628	595	8	&	&	CCONJ
admet-628	595	9	dmpk	dmpk	PROPN
admet-628	595	10	7(1	7(1	PROPN
admet-628	595	11	)	)	PUNCT
admet-628	595	12	(	(	PUNCT
admet-628	595	13	2019	2019	NUM
admet-628	595	14	)	)	PUNCT
admet-628	595	15	22	22	NUM
admet-628	595	16	-	-	SYM
admet-628	595	17	43	43	NUM
admet-628	595	18	a	a	DET
admet-628	595	19	physiologically	physiologically	ADV
admet-628	595	20	-	-	PUNCT
admet-628	595	21	based	base	VERB
admet-628	595	22	pharmacokinetic	pharmacokinetic	ADJ
admet-628	595	23	model	model	NOUN
admet-628	595	24	for	for	ADP
admet-628	595	25	oseltamivir	oseltamivir	PROPN
admet-628	595	26	doi	doi	PROPN
admet-628	595	27	:	:	PUNCT
admet-628	595	28	10.5599	10.5599	NUM
admet-628	595	29	/	/	SYM
admet-628	595	30	admet.628	admet.628	PROPN
admet-628	595	31	41	41	NUM
admet-628	596	1	[	[	X
admet-628	596	2	43	43	NUM
admet-628	596	3	]	]	PUNCT
admet-628	596	4	a.	a.	NOUN
admet-628	596	5	ose	ose	PROPN
admet-628	596	6	,	,	PUNCT
admet-628	596	7	h.	h.	PROPN
admet-628	596	8	kusuhara	kusuhara	PROPN
admet-628	596	9	,	,	PUNCT
admet-628	596	10	k.	k.	PROPN
admet-628	596	11	yamatsugu	yamatsugu	PROPN
admet-628	596	12	,	,	PUNCT
admet-628	596	13	m.	m.	PROPN
admet-628	596	14	kanai	kanai	PROPN
admet-628	596	15	,	,	PUNCT
admet-628	596	16	m.	m.	NOUN
admet-628	596	17	shibasaki	shibasaki	NOUN
admet-628	596	18	,	,	PUNCT
admet-628	596	19	t.	t.	PROPN
admet-628	596	20	fujita	fujita	PROPN
admet-628	596	21	,	,	PUNCT
admet-628	596	22	a.yamamoto	a.yamamoto	NOUN
admet-628	596	23	,	,	PUNCT
admet-628	596	24	y.	y.	PROPN
admet-628	596	25	sugiyama	sugiyama	PROPN
admet-628	596	26	.	.	PUNCT
admet-628	597	1	pglycoprotein	pglycoprotein	PROPN
admet-628	597	2	restricts	restrict	VERB
admet-628	597	3	the	the	DET
admet-628	597	4	penetration	penetration	NOUN
admet-628	597	5	of	of	ADP
admet-628	597	6	oseltamivir	oseltamivir	PROPN
admet-628	597	7	across	across	ADP
admet-628	597	8	the	the	DET
admet-628	597	9	blood	blood	NOUN
admet-628	597	10	–	–	PUNCT
admet-628	597	11	brain	brain	NOUN
admet-628	597	12	barrier	barrier	NOUN
admet-628	597	13	.	.	PUNCT
admet-628	598	1	drug	drug	NOUN
admet-628	598	2	metab	metab	NOUN
admet-628	598	3	.	.	PUNCT
admet-628	599	1	dispos	dispos	PROPN
admet-628	599	2	.	.	PUNCT
admet-628	600	1	2	2	NUM
admet-628	600	2	(	(	PUNCT
admet-628	600	3	2008	2008	NUM
admet-628	600	4	)	)	PUNCT
admet-628	601	1	427–434	427–434	NUM
admet-628	601	2	.	.	PUNCT
admet-628	602	1	[	[	X
admet-628	602	2	44	44	NUM
admet-628	602	3	]	]	PUNCT
admet-628	602	4	g.	g.	PROPN
admet-628	602	5	hoffmann	hoffmann	PROPN
admet-628	602	6	,	,	PUNCT
admet-628	602	7	c.	c.	PROPN
admet-628	602	8	funk	funk	NOUN
admet-628	602	9	,	,	PUNCT
admet-628	602	10	s.	s.	PROPN
admet-628	602	11	fowler	fowler	PROPN
admet-628	602	12	,	,	PUNCT
admet-628	602	13	m.b	m.b	PROPN
admet-628	602	14	.	.	PROPN
admet-628	602	15	otteneder	otteneder	PROPN
admet-628	602	16	,	,	PUNCT
admet-628	602	17	a.	a.	NOUN
admet-628	602	18	breidenbach	breidenbach	PROPN
admet-628	602	19	,	,	PUNCT
admet-628	602	20	c.r	c.r	PROPN
admet-628	602	21	.	.	PROPN
admet-628	602	22	rayner	rayner	PROPN
admet-628	602	23	,	,	PUNCT
admet-628	602	24	t.	t.	PROPN
admet-628	602	25	chu	chu	PROPN
admet-628	602	26	,	,	PUNCT
admet-628	602	27	e.p	e.p	PROPN
admet-628	602	28	.	.	PROPN
admet-628	602	29	prinssen	prinssen	NOUN
admet-628	602	30	.	.	PUNCT
admet-628	603	1	nonclinical	nonclinical	ADJ
admet-628	603	2	pharmacokinetics	pharmacokinetic	NOUN
admet-628	603	3	of	of	ADP
admet-628	603	4	oseltamivir	oseltamivir	PROPN
admet-628	603	5	and	and	CCONJ
admet-628	603	6	oseltamivir	oseltamivir	PROPN
admet-628	603	7	carboxylate	carboxylate	VERB
admet-628	603	8	in	in	ADP
admet-628	603	9	the	the	DET
admet-628	603	10	central	central	ADJ
admet-628	603	11	nervous	nervous	ADJ
admet-628	603	12	system	system	NOUN
admet-628	603	13	.	.	PUNCT
admet-628	604	1	antimicrob	antimicrob	PROPN
admet-628	604	2	.	.	PUNCT
admet-628	605	1	agents	agent	NOUN
admet-628	605	2	chemother	chemother	PROPN
admet-628	605	3	.	.	PUNCT
admet-628	606	1	53	53	NUM
admet-628	606	2	(	(	PUNCT
admet-628	606	3	2009	2009	NUM
admet-628	606	4	)	)	PUNCT
admet-628	606	5	4753	4753	NUM
admet-628	606	6	-	-	SYM
admet-628	606	7	4761	4761	NUM
admet-628	606	8	.	.	PUNCT
admet-628	607	1	[	[	X
admet-628	607	2	45	45	NUM
admet-628	607	3	]	]	X
admet-628	607	4	c.h	c.h	PROPN
admet-628	607	5	.	.	PROPN
admet-628	607	6	hsueh	hsueh	PROPN
admet-628	607	7	,	,	PUNCT
admet-628	607	8	v.	v.	PROPN
admet-628	607	9	hsu	hsu	PROPN
admet-628	607	10	,	,	PUNCT
admet-628	607	11	p.	p.	PROPN
admet-628	607	12	zhao	zhao	PROPN
admet-628	607	13	,	,	PUNCT
admet-628	607	14	l.	l.	PROPN
admet-628	607	15	zhang	zhang	PROPN
admet-628	607	16	,	,	PUNCT
admet-628	607	17	k.m	k.m	PROPN
admet-628	607	18	.	.	PROPN
admet-628	607	19	giacomini	giacomini	PROPN
admet-628	607	20	.	.	PUNCT
admet-628	607	21	s.m	s.m	PROPN
admet-628	607	22	.	.	PROPN
admet-628	607	23	huang	huang	PROPN
admet-628	607	24	,	,	PUNCT
admet-628	607	25	pbpk	pbpk	NOUN
admet-628	607	26	modeling	modeling	NOUN
admet-628	607	27	of	of	ADP
admet-628	607	28	the	the	DET
admet-628	607	29	effect	effect	NOUN
admet-628	607	30	of	of	ADP
admet-628	607	31	reduced	reduce	VERB
admet-628	607	32	kidney	kidney	NOUN
admet-628	607	33	function	function	NOUN
admet-628	607	34	on	on	ADP
admet-628	607	35	the	the	DET
admet-628	607	36	pharmacokinetics	pharmacokinetic	NOUN
admet-628	607	37	of	of	ADP
admet-628	607	38	drugs	drug	NOUN
admet-628	607	39	excreted	excrete	VERB
admet-628	607	40	renally	renally	ADV
admet-628	607	41	by	by	ADP
admet-628	607	42	organic	organic	ADJ
admet-628	607	43	anion	anion	NOUN
admet-628	607	44	transporters	transporter	NOUN
admet-628	607	45	,	,	PUNCT
admet-628	607	46	clin	clin	PROPN
admet-628	607	47	.	.	PUNCT
admet-628	608	1	pharmacol	pharmacol	PROPN
admet-628	608	2	.	.	PUNCT
admet-628	609	1	103(3	103(3	NUM
admet-628	609	2	)	)	PUNCT
admet-628	609	3	(	(	PUNCT
admet-628	609	4	2018	2018	NUM
admet-628	609	5	)	)	PUNCT
admet-628	609	6	485	485	NUM
admet-628	609	7	-	-	SYM
admet-628	609	8	492	492	NUM
admet-628	609	9	.	.	PUNCT
admet-628	610	1	appendix	appendix	VERB
admet-628	610	2	the	the	DET
admet-628	610	3	mass	mass	NOUN
admet-628	610	4	balance	balance	NOUN
admet-628	610	5	equations	equation	NOUN
admet-628	610	6	for	for	ADP
admet-628	610	7	non	non	ADJ
admet-628	610	8	-	-	ADJ
admet-628	610	9	eliminating	eliminating	ADJ
admet-628	610	10	organs	organ	NOUN
admet-628	610	11	and	and	CCONJ
admet-628	610	12	tissues	tissue	NOUN
admet-628	610	13	such	such	ADJ
admet-628	610	14	as	as	ADP
admet-628	610	15	lung	lung	NOUN
admet-628	610	16	,	,	PUNCT
admet-628	610	17	brain	brain	NOUN
admet-628	610	18	,	,	PUNCT
admet-628	610	19	spleen	spleen	NOUN
admet-628	610	20	,	,	PUNCT
admet-628	610	21	muscle	muscle	NOUN
admet-628	610	22	,	,	PUNCT
admet-628	610	23	and	and	CCONJ
admet-628	610	24	the	the	DET
admet-628	610	25	rest	rest	NOUN
admet-628	610	26	of	of	ADP
admet-628	610	27	body	body	NOUN
admet-628	610	28	are	be	AUX
admet-628	610	29	as	as	SCONJ
admet-628	610	30	follows	follow	VERB
admet-628	610	31	:	:	PUNCT
admet-628	610	32	xyp	xyp	PROPN
admet-628	611	1	xyp	xyp	PROPN
admet-628	612	1	xy	xy	PROPN
admet-628	612	2	xy	xy	PROPN
admet-628	612	3	bap	bap	PROPN
admet-628	612	4	xyp	xyp	PROPN
admet-628	613	1	d	d	PROPN
admet-628	613	2	d	d	X
admet-628	613	3	c	c	NOUN
admet-628	613	4	c	c	NOUN
admet-628	613	5	v	v	NOUN
admet-628	613	6	q	q	X
admet-628	613	7	c	c	NOUN
admet-628	613	8	t	t	NOUN
admet-628	613	9	r	r	NOUN
admet-628	613	10			NOUN
admet-628	613	11			NOUN
admet-628	613	12			PROPN
admet-628	613	13			PROPN
admet-628	613	14			CCONJ
admet-628	614	1			PROPN
admet-628	614	2			NOUN
admet-628	614	3	(	(	PUNCT
admet-628	614	4	1a	1a	NOUN
admet-628	614	5	)	)	PUNCT
admet-628	614	6	xyc	xyc	X
admet-628	615	1	xyc	xyc	PUNCT
admet-628	616	1	xy	xy	PROPN
admet-628	616	2	xy	xy	PROPN
admet-628	616	3	bap	bap	PROPN
admet-628	616	4	xyc	xyc	PUNCT
admet-628	617	1	d	d	PUNCT
admet-628	617	2	d	d	X
admet-628	617	3	c	c	NOUN
admet-628	617	4	c	c	NOUN
admet-628	617	5	v	v	NOUN
admet-628	617	6	q	q	X
admet-628	617	7	c	c	NOUN
admet-628	617	8	t	t	NOUN
admet-628	617	9	r	r	NOUN
admet-628	617	10			NOUN
admet-628	617	11			NOUN
admet-628	617	12			PROPN
admet-628	617	13			PROPN
admet-628	617	14			CCONJ
admet-628	618	1			PROPN
admet-628	618	2			NOUN
admet-628	618	3	(	(	PUNCT
admet-628	618	4	1b	1b	NUM
admet-628	618	5	)	)	PUNCT
admet-628	618	6	where	where	SCONJ
admet-628	618	7	xy	xy	PROPN
admet-628	618	8	represents	represent	VERB
admet-628	618	9	the	the	DET
admet-628	618	10	lung	lung	NOUN
admet-628	618	11	,	,	PUNCT
admet-628	618	12	brain	brain	NOUN
admet-628	618	13	,	,	PUNCT
admet-628	618	14	spleen	spleen	NOUN
admet-628	618	15	,	,	PUNCT
admet-628	618	16	muscle	muscle	NOUN
admet-628	618	17	,	,	PUNCT
admet-628	618	18	and	and	CCONJ
admet-628	618	19	the	the	DET
admet-628	618	20	rest	rest	NOUN
admet-628	618	21	of	of	ADP
admet-628	618	22	body	body	NOUN
admet-628	618	23	.	.	PUNCT
admet-628	619	1	the	the	DET
admet-628	619	2	terms	term	NOUN
admet-628	619	3	qxy	qxy	PROPN
admet-628	619	4	,	,	PUNCT
admet-628	619	5	vxy	vxy	VERB
admet-628	619	6	and	and	CCONJ
admet-628	619	7	rxy	rxy	ADJ
admet-628	619	8	represent	represent	VERB
admet-628	619	9	tissue	tissue	NOUN
admet-628	619	10	blood	blood	NOUN
admet-628	619	11	flow	flow	NOUN
admet-628	619	12	,	,	PUNCT
admet-628	619	13	volume	volume	NOUN
admet-628	619	14	and	and	CCONJ
admet-628	619	15	tissue	tissue	NOUN
admet-628	619	16	/	/	SYM
admet-628	619	17	plasma	plasma	NOUN
admet-628	619	18	partition	partition	NOUN
admet-628	619	19	coefficient	coefficient	NOUN
admet-628	619	20	,	,	PUNCT
admet-628	619	21	respectively	respectively	ADV
admet-628	619	22	;	;	PUNCT
admet-628	619	23	subscripts	subscript	NOUN
admet-628	619	24	p	p	NOUN
admet-628	619	25	and	and	CCONJ
admet-628	619	26	c	c	PROPN
admet-628	619	27	represent	represent	VERB
admet-628	619	28	op	op	NOUN
admet-628	619	29	and	and	CCONJ
admet-628	619	30	oc	oc	NOUN
admet-628	619	31	,	,	PUNCT
admet-628	619	32	respectively	respectively	ADV
admet-628	619	33	.	.	PUNCT
admet-628	620	1	brain	brain	PROPN
admet-628	620	2	brp	brp	PROPN
admet-628	620	3	brp	brp	PROPN
admet-628	620	4	br	br	PROPN
admet-628	620	5	br	br	PROPN
admet-628	620	6	bap	bap	PROPN
admet-628	620	7	brp	brp	PROPN
admet-628	621	1	d	d	PROPN
admet-628	621	2	d	d	PROPN
admet-628	621	3	c	c	NOUN
admet-628	621	4	c	c	NOUN
admet-628	621	5	v	v	NOUN
admet-628	621	6	q	q	X
admet-628	621	7	c	c	NOUN
admet-628	621	8	t	t	NOUN
admet-628	621	9	r	r	NOUN
admet-628	621	10			NOUN
admet-628	621	11			NOUN
admet-628	621	12			PROPN
admet-628	621	13			PROPN
admet-628	621	14			CCONJ
admet-628	622	1			ADJ
admet-628	622	2			NOUN
admet-628	622	3	(	(	PUNCT
admet-628	622	4	2a	2a	NUM
admet-628	622	5	)	)	PUNCT
admet-628	622	6	brc	brc	NOUN
admet-628	622	7	brc	brc	PROPN
admet-628	622	8	br	br	PROPN
admet-628	622	9	br	br	PROPN
admet-628	623	1	bap	bap	PROPN
admet-628	624	1	d	d	PROPN
admet-628	624	2	d	d	PROPN
admet-628	624	3	cbrc	cbrc	NOUN
admet-628	624	4	c	c	NOUN
admet-628	624	5	c	c	NOUN
admet-628	624	6	v	v	NOUN
admet-628	624	7	q	q	X
admet-628	624	8	c	c	NOUN
admet-628	624	9	t	t	NOUN
admet-628	624	10	r	r	NOUN
admet-628	624	11			NOUN
admet-628	624	12			NOUN
admet-628	625	1			PROPN
admet-628	626	1			PROPN
admet-628	626	2			CCONJ
admet-628	627	1			PROPN
admet-628	627	2			NOUN
admet-628	627	3	(	(	PUNCT
admet-628	627	4	2b	2b	NUM
admet-628	627	5	)	)	PUNCT
admet-628	627	6	lung	lung	PROPN
admet-628	627	7	lgp	lgp	PROPN
admet-628	627	8	lgp	lgp	PROPN
admet-628	627	9	lg	lg	PROPN
admet-628	627	10	lg	lg	PROPN
admet-628	627	11	bvp	bvp	PROPN
admet-628	627	12	lgp	lgp	PROPN
admet-628	627	13	d	d	PROPN
admet-628	627	14	d	d	PROPN
admet-628	627	15	c	c	PROPN
admet-628	627	16	c	c	NOUN
admet-628	627	17	v	v	NOUN
admet-628	627	18	q	q	X
admet-628	627	19	c	c	NOUN
admet-628	627	20	t	t	NOUN
admet-628	627	21	r	r	NOUN
admet-628	627	22			NOUN
admet-628	627	23			NOUN
admet-628	628	1			PROPN
admet-628	629	1			PROPN
admet-628	629	2			CCONJ
admet-628	630	1			PROPN
admet-628	630	2			NOUN
admet-628	630	3	(	(	PUNCT
admet-628	630	4	3a	3a	NUM
admet-628	630	5	)	)	PUNCT
admet-628	630	6	lgc	lgc	ADJ
admet-628	630	7	lgc	lgc	ADJ
admet-628	630	8	lg	lg	NOUN
admet-628	630	9	lg	lg	PROPN
admet-628	630	10	bvc	bvc	PROPN
admet-628	631	1	d	d	PROPN
admet-628	631	2	d	d	PROPN
admet-628	631	3	clgc	clgc	NOUN
admet-628	632	1	c	c	NOUN
admet-628	632	2	c	c	NOUN
admet-628	632	3	v	v	NOUN
admet-628	632	4	q	q	X
admet-628	632	5	c	c	NOUN
admet-628	632	6	t	t	NOUN
admet-628	632	7	r	r	NOUN
admet-628	632	8			NOUN
admet-628	632	9			NOUN
admet-628	632	10			PROPN
admet-628	632	11			PROPN
admet-628	632	12			CCONJ
admet-628	633	1			PROPN
admet-628	633	2			NOUN
admet-628	633	3	(	(	PUNCT
admet-628	633	4	3b	3b	NUM
admet-628	633	5	)	)	PUNCT
admet-628	633	6	gut	gut	NOUN
admet-628	633	7	contents	content	NOUN
admet-628	634	1			PROPN
admet-628	634	2	cgcp	cgcp	PROPN
admet-628	634	3	gc	gc	PROPN
admet-628	634	4	d	d	PROPN
admet-628	634	5	d	d	PROPN
admet-628	634	6	p	p	PROPN
admet-628	634	7	gcp	gcp	PROPN
admet-628	635	1	gt	gt	PROPN
admet-628	635	2	c	c	PROPN
admet-628	635	3	v	v	INTJ
admet-628	635	4	kf	kf	PROPN
admet-628	635	5	c	c	NOUN
admet-628	635	6	v	v	NOUN
admet-628	635	7	t	t	PROPN
admet-628	635	8			PROPN
admet-628	635	9			PROPN
admet-628	635	10	(	(	PUNCT
admet-628	635	11	4a	4a	NUM
admet-628	635	12	)	)	PUNCT
admet-628	635	13			PROPN
admet-628	635	14	cgcc	cgcc	PROPN
admet-628	636	1	gc	gc	PROPN
admet-628	636	2	d	d	PROPN
admet-628	636	3	d	d	PROPN
admet-628	636	4	c	c	PROPN
admet-628	636	5	gcc	gcc	NOUN
admet-628	636	6	gt	gt	PROPN
admet-628	636	7	c	c	PROPN
admet-628	636	8	v	v	INTJ
admet-628	636	9	kf	kf	PROPN
admet-628	636	10	c	c	NOUN
admet-628	636	11	v	v	NOUN
admet-628	636	12	t	t	PROPN
admet-628	636	13			PROPN
admet-628	636	14			PROPN
admet-628	636	15	(	(	PUNCT
admet-628	636	16	4b	4b	X
admet-628	636	17	)	)	PUNCT
admet-628	636	18	kidney	kidney	PROPN
admet-628	636	19	kdp	kdp	PROPN
admet-628	636	20	kdp	kdp	PROPN
admet-628	636	21	kd	kd	PROPN
admet-628	636	22	kd	kd	PROPN
admet-628	636	23	bap	bap	PROPN
admet-628	636	24	p	p	PROPN
admet-628	636	25	bap	bap	PROPN
admet-628	636	26	kdp	kdp	PROPN
admet-628	637	1	d	d	PROPN
admet-628	637	2	cl	cl	PROPN
admet-628	638	1	d	d	NOUN
admet-628	638	2	c	c	NOUN
admet-628	638	3	c	c	NOUN
admet-628	638	4	v	v	NOUN
admet-628	638	5	q	q	X
admet-628	638	6	c	c	NOUN
admet-628	638	7	c	c	NOUN
admet-628	638	8	t	t	NOUN
admet-628	638	9	r	r	NOUN
admet-628	638	10			NOUN
admet-628	638	11			PROPN
admet-628	638	12			PROPN
admet-628	638	13			PROPN
admet-628	638	14			PROPN
admet-628	638	15			CCONJ
admet-628	638	16			PROPN
admet-628	638	17			NOUN
admet-628	638	18	(	(	PUNCT
admet-628	638	19	5a	5a	NUM
admet-628	638	20	)	)	PUNCT
admet-628	638	21	g.	g.	PROPN
admet-628	638	22	gao	gao	PROPN
admet-628	638	23	et	et	PROPN
admet-628	638	24	al	al	PROPN
admet-628	638	25	.	.	PROPN
admet-628	638	26	admet	admet	PROPN
admet-628	638	27	&	&	CCONJ
admet-628	638	28	dmpk	dmpk	PROPN
admet-628	638	29	7(1	7(1	PROPN
admet-628	638	30	)	)	PUNCT
admet-628	638	31	(	(	PUNCT
admet-628	638	32	2019	2019	NUM
admet-628	638	33	)	)	PUNCT
admet-628	638	34	22	22	NUM
admet-628	638	35	-	-	SYM
admet-628	638	36	43	43	NUM
admet-628	638	37	42	42	NUM
admet-628	638	38	kdc	kdc	NOUN
admet-628	638	39	kdc	kdc	PROPN
admet-628	638	40	kd	kd	PROPN
admet-628	638	41	kd	kd	PROPN
admet-628	638	42	bac	bac	PROPN
admet-628	638	43	c	c	PROPN
admet-628	638	44	bac	bac	PROPN
admet-628	638	45	kdc	kdc	PROPN
admet-628	639	1	d	d	NOUN
admet-628	639	2	cl	cl	NOUN
admet-628	640	1	d	d	NOUN
admet-628	640	2	c	c	NOUN
admet-628	640	3	c	c	NOUN
admet-628	640	4	v	v	NOUN
admet-628	640	5	q	q	X
admet-628	640	6	c	c	NOUN
admet-628	640	7	c	c	NOUN
admet-628	640	8	t	t	NOUN
admet-628	640	9	r	r	NOUN
admet-628	640	10			NOUN
admet-628	640	11			PROPN
admet-628	640	12			PROPN
admet-628	640	13			PROPN
admet-628	640	14			PROPN
admet-628	640	15			CCONJ
admet-628	640	16			PROPN
admet-628	640	17			NOUN
admet-628	640	18	(	(	PUNCT
admet-628	640	19	5b	5b	NUM
admet-628	640	20	)	)	PUNCT
admet-628	641	1	venous	venous	ADJ
admet-628	641	2	blood	blood	NOUN
admet-628	641	3	cbvp	cbvp	PROPN
admet-628	641	4	mspftp	mspftp	PROPN
admet-628	641	5	hrp	hrp	PROPN
admet-628	641	6	kdp	kdp	PROPN
admet-628	641	7	lvp	lvp	PROPN
admet-628	641	8	bv	bv	PROPN
admet-628	641	9	ft	ft	PROPN
admet-628	641	10	hr	hr	PROPN
admet-628	641	11	kd	kd	PROPN
admet-628	641	12	ms	ms	PROPN
admet-628	641	13	lv	lv	PROPN
admet-628	641	14	ftp	ftp	PROPN
admet-628	641	15	hrp	hrp	PROPN
admet-628	641	16	kdp	kdp	PROPN
admet-628	641	17	msp	msp	PROPN
admet-628	641	18	lvp	lvp	PROPN
admet-628	641	19	brp	brp	PROPN
admet-628	641	20	rbp	rbp	PROPN
admet-628	641	21	br	br	PROPN
admet-628	641	22	rb	rb	PROPN
admet-628	641	23	c	c	PROPN
admet-628	641	24	bvp	bvp	PROPN
admet-628	641	25	brp	brp	PROPN
admet-628	641	26	rbp	rbp	PROPN
admet-628	642	1	d	d	PROPN
admet-628	642	2	d	d	X
admet-628	642	3	c	c	PROPN
admet-628	642	4	cc	cc	X
admet-628	642	5	c	c	PROPN
admet-628	642	6	c	c	NOUN
admet-628	642	7	c	c	NOUN
admet-628	642	8	v	v	NOUN
admet-628	642	9	q	q	X
admet-628	642	10	q	q	X
admet-628	642	11	q	q	X
admet-628	642	12	q	q	X
admet-628	642	13	q	q	X
admet-628	642	14	t	t	NOUN
admet-628	642	15	r	r	NOUN
admet-628	642	16	r	r	NOUN
admet-628	642	17	r	r	NOUN
admet-628	642	18	r	r	NOUN
admet-628	642	19	r	r	NOUN
admet-628	642	20	c	c	NOUN
admet-628	642	21	c	c	NOUN
admet-628	642	22	q	q	NOUN
admet-628	642	23	q	q	X
admet-628	642	24	q	q	X
admet-628	642	25	c	c	NOUN
admet-628	642	26	r	r	NOUN
admet-628	642	27	r	r	NOUN
admet-628	642	28			PROPN
admet-628	642	29			ADV
admet-628	642	30			PUNCT
admet-628	642	31			PROPN
admet-628	642	32			PROPN
admet-628	642	33			PROPN
admet-628	642	34			PUNCT
admet-628	642	35			PUNCT
admet-628	642	36			X
admet-628	642	37	(	(	PUNCT
admet-628	642	38	6a	6a	NOUN
admet-628	642	39	)	)	PUNCT
admet-628	642	40	cbvc	cbvc	VERB
admet-628	642	41	ftc	ftc	PROPN
admet-628	642	42	hrc	hrc	PROPN
admet-628	642	43	kdc	kdc	PROPN
admet-628	642	44	msc	msc	PROPN
admet-628	642	45	lvc	lvc	PROPN
admet-628	642	46	bv	bv	PROPN
admet-628	642	47	ft	ft	PROPN
admet-628	642	48	hr	hr	PROPN
admet-628	642	49	kd	kd	PROPN
admet-628	642	50	ms	ms	PROPN
admet-628	642	51	lv	lv	PROPN
admet-628	642	52	ftc	ftc	PROPN
admet-628	642	53	hrc	hrc	PROPN
admet-628	642	54	kdc	kdc	PROPN
admet-628	642	55	msc	msc	PROPN
admet-628	642	56	lvc	lvc	PROPN
admet-628	642	57	brc	brc	PROPN
admet-628	642	58	rbc	rbc	PROPN
admet-628	642	59	br	br	PROPN
admet-628	642	60	rb	rb	PROPN
admet-628	642	61	c	c	PROPN
admet-628	642	62	bvc	bvc	PROPN
admet-628	642	63	brc	brc	PROPN
admet-628	642	64	rbc	rbc	PROPN
admet-628	643	1	d	d	PROPN
admet-628	643	2	d	d	PROPN
admet-628	643	3	c	c	NOUN
admet-628	643	4	c	c	NOUN
admet-628	644	1	c	c	NOUN
admet-628	644	2	c	c	NOUN
admet-628	644	3	c	c	NOUN
admet-628	644	4	c	c	NOUN
admet-628	644	5	v	v	NOUN
admet-628	644	6	q	q	X
admet-628	644	7	q	q	X
admet-628	644	8	q	q	X
admet-628	644	9	q	q	X
admet-628	644	10	q	q	X
admet-628	644	11	t	t	NOUN
admet-628	644	12	r	r	NOUN
admet-628	644	13	r	r	NOUN
admet-628	644	14	r	r	NOUN
admet-628	644	15	r	r	NOUN
admet-628	644	16	r	r	NOUN
admet-628	644	17	c	c	NOUN
admet-628	644	18	c	c	NOUN
admet-628	644	19	q	q	NOUN
admet-628	644	20	q	q	X
admet-628	644	21	q	q	X
admet-628	644	22	c	c	NOUN
admet-628	644	23	r	r	NOUN
admet-628	644	24	r	r	NOUN
admet-628	644	25			PROPN
admet-628	644	26			ADV
admet-628	644	27			PUNCT
admet-628	644	28			PROPN
admet-628	644	29			PROPN
admet-628	644	30			PROPN
admet-628	644	31			PUNCT
admet-628	644	32			PUNCT
admet-628	644	33			X
admet-628	644	34	(	(	PUNCT
admet-628	644	35	6b	6b	NOUN
admet-628	644	36	)	)	PUNCT
admet-628	644	37	mixed	mixed	ADJ
admet-628	644	38	venous	venous	ADJ
admet-628	644	39	plasma	plasma	NOUN
admet-628	644	40	bvp	bvp	NOUN
admet-628	644	41	pvp	pvp	VERB
admet-628	644	42	pblplr	pblplr	NOUN
admet-628	645	1	c	c	NOUN
admet-628	645	2	c	c	NOUN
admet-628	645	3			NUM
admet-628	645	4	(	(	PUNCT
admet-628	645	5	7a	7a	NUM
admet-628	645	6	)	)	PUNCT
admet-628	645	7	bvc	bvc	ADJ
admet-628	645	8	pvc	pvc	NOUN
admet-628	645	9	cblplr	cblplr	NOUN
admet-628	645	10	c	c	PROPN
admet-628	645	11	c	c	NOUN
admet-628	645	12			NUM
admet-628	645	13	(	(	PUNCT
admet-628	645	14	7b	7b	NOUN
admet-628	645	15	)	)	PUNCT
admet-628	645	16	cpvp	cpvp	NOUN
admet-628	645	17	and	and	CCONJ
admet-628	645	18	cpvc	cpvc	PROPN
admet-628	645	19	are	be	AUX
admet-628	645	20	the	the	DET
admet-628	645	21	concentration	concentration	NOUN
admet-628	645	22	in	in	ADP
admet-628	645	23	mixed	mixed	ADJ
admet-628	645	24	venous	venous	ADJ
admet-628	645	25	plasma	plasma	NOUN
admet-628	645	26	of	of	ADP
admet-628	645	27	op	op	NOUN
admet-628	645	28	and	and	CCONJ
admet-628	645	29	oc	oc	PROPN
admet-628	645	30	,	,	PUNCT
admet-628	645	31	cbvp	cbvp	NOUN
admet-628	645	32	and	and	CCONJ
admet-628	645	33	cbvc	cbvc	ADJ
admet-628	645	34	are	be	AUX
admet-628	645	35	the	the	DET
admet-628	645	36	concentration	concentration	NOUN
admet-628	645	37	in	in	ADP
admet-628	645	38	mixed	mixed	ADJ
admet-628	645	39	venous	venous	ADJ
admet-628	645	40	blood	blood	NOUN
admet-628	645	41	,	,	PUNCT
admet-628	645	42	blplr	blplr	NOUN
admet-628	645	43	is	be	AUX
admet-628	645	44	the	the	DET
admet-628	645	45	concentration	concentration	NOUN
admet-628	645	46	ratio	ratio	NOUN
admet-628	645	47	in	in	ADP
admet-628	645	48	blood	blood	NOUN
admet-628	645	49	and	and	CCONJ
admet-628	645	50	plasma	plasma	NOUN
admet-628	645	51	.	.	PUNCT
admet-628	646	1	arterial	arterial	ADJ
admet-628	646	2	blood	blood	NOUN
admet-628	646	3	lgpbap	lgpbap	PROPN
admet-628	646	4	ba	ba	PROPN
admet-628	646	5	c	c	PROPN
admet-628	646	6	bap	bap	PROPN
admet-628	646	7	lgp	lgp	PROPN
admet-628	646	8	d	d	PROPN
admet-628	646	9	d	d	PROPN
admet-628	646	10	cc	cc	PROPN
admet-628	646	11	v	v	NOUN
admet-628	646	12	q	q	PROPN
admet-628	646	13	c	c	NOUN
admet-628	646	14	t	t	NOUN
admet-628	646	15	r	r	NOUN
admet-628	646	16			NOUN
admet-628	646	17			NOUN
admet-628	646	18			PROPN
admet-628	646	19			PROPN
admet-628	646	20			CCONJ
admet-628	647	1			PROPN
admet-628	647	2			NOUN
admet-628	647	3	(	(	PUNCT
admet-628	647	4	8a	8a	NUM
admet-628	647	5	)	)	PUNCT
admet-628	647	6	bac	bac	PROPN
admet-628	647	7	lgc	lgc	PROPN
admet-628	648	1	ba	ba	PROPN
admet-628	648	2	c	c	PROPN
admet-628	648	3	bac	bac	PROPN
admet-628	648	4	lgc	lgc	PROPN
admet-628	649	1	d	d	PROPN
admet-628	649	2	d	d	X
admet-628	649	3	c	c	NOUN
admet-628	649	4	c	c	NOUN
admet-628	649	5	v	v	NOUN
admet-628	649	6	q	q	X
admet-628	649	7	c	c	NOUN
admet-628	649	8	t	t	NOUN
admet-628	649	9	r	r	NOUN
admet-628	649	10			NOUN
admet-628	649	11			NOUN
admet-628	649	12			PROPN
admet-628	649	13			PROPN
admet-628	649	14			CCONJ
admet-628	650	1			PROPN
admet-628	650	2			NOUN
admet-628	650	3	(	(	PUNCT
admet-628	650	4	8b	8b	NUM
admet-628	650	5	)	)	PUNCT
admet-628	650	6	liver	liver	NOUN
admet-628	650	7			NOUN
admet-628	650	8			PROPN
admet-628	650	9	gup	gup	NOUN
admet-628	650	10	spplvp	spplvp	NOUN
admet-628	651	1	lv	lv	PROPN
admet-628	651	2	lv	lv	PROPN
admet-628	651	3	gu	gu	NOUN
admet-628	651	4	sp	sp	ADP
admet-628	651	5	bap	bap	PROPN
admet-628	651	6	gu	gu	PROPN
admet-628	651	7	gup	gup	PROPN
admet-628	651	8	spp	spp	PROPN
admet-628	651	9	lvp	lvp	PROPN
admet-628	651	10	lvp	lvp	PROPN
admet-628	651	11	lv	lv	PROPN
admet-628	651	12	max	max	PROPN
admet-628	651	13	,	,	PUNCT
admet-628	651	14	p	p	PROPN
admet-628	651	15	lvp	lvp	PROPN
admet-628	651	16	lvp	lvp	PROPN
admet-628	651	17	lvp	lvp	PROPN
admet-628	651	18	m	m	PROPN
admet-628	651	19	,	,	PUNCT
admet-628	651	20	p	p	PROPN
admet-628	651	21	lvp	lvp	PROPN
admet-628	651	22	d	d	PROPN
admet-628	651	23	d	d	X
admet-628	651	24	c	c	PROPN
admet-628	651	25	cc	cc	PROPN
admet-628	651	26	v	v	NOUN
admet-628	651	27	q	q	NOUN
admet-628	651	28	q	q	X
admet-628	651	29	q	q	X
admet-628	651	30	c	c	NOUN
admet-628	651	31	q	q	NOUN
admet-628	651	32	qsp	qsp	NOUN
admet-628	651	33	t	t	NOUN
admet-628	651	34	r	r	NOUN
admet-628	651	35	r	r	NOUN
admet-628	651	36	c	c	NOUN
admet-628	651	37	c	c	NOUN
admet-628	651	38	q	q	X
admet-628	651	39	v	v	NOUN
admet-628	651	40	r	r	NOUN
admet-628	651	41	c	c	NOUN
admet-628	651	42	r	r	NOUN
admet-628	651	43	k	k	NOUN
admet-628	651	44	r	r	PROPN
admet-628	651	45			PROPN
admet-628	651	46			PROPN
admet-628	651	47			PROPN
admet-628	651	48			PUNCT
admet-628	651	49			PUNCT
admet-628	651	50			PROPN
admet-628	651	51			PROPN
admet-628	651	52			PROPN
admet-628	651	53			NOUN
admet-628	651	54			NOUN
admet-628	651	55			PROPN
admet-628	651	56			PROPN
admet-628	651	57			PROPN
admet-628	651	58			NOUN
admet-628	651	59	(	(	PUNCT
admet-628	651	60	9a	9a	NOUN
admet-628	651	61	)	)	PUNCT
admet-628	651	62			PROPN
admet-628	651	63	lvc	lvc	PROPN
admet-628	651	64	guc	guc	PROPN
admet-628	651	65	spc	spc	PROPN
admet-628	651	66	lv	lv	PROPN
admet-628	651	67	lv	lv	PROPN
admet-628	651	68	gu	gu	PROPN
admet-628	651	69	sp	sp	ADP
admet-628	651	70	bac	bac	PROPN
admet-628	651	71	gu	gu	PROPN
admet-628	651	72	sp	sp	ADP
admet-628	651	73	guc	guc	PROPN
admet-628	651	74	spc	spc	PROPN
admet-628	651	75	lvc	lvc	PROPN
admet-628	651	76	lvp	lvp	PROPN
admet-628	651	77	lv	lv	PROPN
admet-628	651	78	max	max	PROPN
admet-628	651	79	,	,	PUNCT
admet-628	651	80	p	p	NOUN
admet-628	651	81	lvc	lvc	PROPN
admet-628	651	82	lvp	lvp	PROPN
admet-628	651	83	lvp	lvp	PROPN
admet-628	651	84	m	m	PROPN
admet-628	651	85	,	,	PUNCT
admet-628	651	86	p	p	PROPN
admet-628	651	87	lvp	lvp	PROPN
admet-628	651	88	d	d	PROPN
admet-628	652	1	d	d	X
admet-628	652	2	c	c	NOUN
admet-628	652	3	c	c	NOUN
admet-628	652	4	c	c	NOUN
admet-628	652	5	v	v	NOUN
admet-628	652	6	q	q	X
admet-628	652	7	q	q	X
admet-628	652	8	q	q	X
admet-628	652	9	c	c	X
admet-628	652	10	q	q	X
admet-628	652	11	q	q	X
admet-628	652	12	t	t	NOUN
admet-628	652	13	r	r	NOUN
admet-628	652	14	r	r	NOUN
admet-628	652	15	c	c	NOUN
admet-628	652	16	c	c	NOUN
admet-628	652	17	q	q	NOUN
admet-628	652	18	v	v	NOUN
admet-628	652	19	r	r	NOUN
admet-628	652	20	r	r	NOUN
admet-628	652	21	c	c	NOUN
admet-628	652	22	r	r	NOUN
admet-628	652	23	k	k	NOUN
admet-628	652	24	r	r	PROPN
admet-628	652	25			PROPN
admet-628	652	26			PROPN
admet-628	652	27			PROPN
admet-628	652	28			PUNCT
admet-628	652	29			PUNCT
admet-628	652	30			PROPN
admet-628	652	31			PROPN
admet-628	652	32			PROPN
admet-628	652	33			NOUN
admet-628	652	34			NOUN
admet-628	652	35			PROPN
admet-628	652	36			PROPN
admet-628	652	37			PROPN
admet-628	652	38			NOUN
admet-628	652	39	(	(	PUNCT
admet-628	652	40	9b	9b	NUM
admet-628	652	41	)	)	PUNCT
admet-628	652	42	admet	admet	PROPN
admet-628	652	43	&	&	CCONJ
admet-628	652	44	dmpk	dmpk	PROPN
admet-628	652	45	7(1	7(1	PROPN
admet-628	652	46	)	)	PUNCT
admet-628	652	47	(	(	PUNCT
admet-628	652	48	2019	2019	NUM
admet-628	652	49	)	)	PUNCT
admet-628	652	50	22	22	NUM
admet-628	652	51	-	-	SYM
admet-628	652	52	43	43	NUM
admet-628	652	53	a	a	DET
admet-628	652	54	physiologically	physiologically	ADV
admet-628	652	55	-	-	PUNCT
admet-628	652	56	based	base	VERB
admet-628	652	57	pharmacokinetic	pharmacokinetic	ADJ
admet-628	652	58	model	model	NOUN
admet-628	652	59	for	for	ADP
admet-628	652	60	oseltamivir	oseltamivir	PROPN
admet-628	652	61	doi	doi	PROPN
admet-628	652	62	:	:	PUNCT
admet-628	652	63	10.5599	10.5599	NUM
admet-628	652	64	/	/	SYM
admet-628	652	65	admet.628	admet.628	PROPN
admet-628	652	66	43	43	NUM
admet-628	652	67	gut	gut	NOUN
admet-628	652	68	tissue	tissue	NOUN
admet-628	652	69	gtp	gtp	PROPN
admet-628	652	70	gtp	gtp	PROPN
admet-628	652	71	gt	gt	PROPN
admet-628	653	1	gt	gt	PROPN
admet-628	653	2	bap	bap	PROPN
admet-628	653	3	gtp	gtp	PROPN
admet-628	653	4	d	d	PROPN
admet-628	653	5	rao	rao	PROPN
admet-628	654	1	d	d	X
admet-628	654	2	c	c	NOUN
admet-628	654	3	c	c	NOUN
admet-628	654	4	v	v	NOUN
admet-628	654	5	q	q	X
admet-628	654	6	c	c	NOUN
admet-628	654	7	t	t	NOUN
admet-628	654	8	r	r	NOUN
admet-628	654	9			NOUN
admet-628	654	10			PROPN
admet-628	654	11			PROPN
admet-628	654	12			PROPN
admet-628	654	13			PROPN
admet-628	654	14			CCONJ
admet-628	654	15			PROPN
admet-628	654	16			NOUN
admet-628	654	17	(	(	PUNCT
admet-628	654	18	10a	10a	NOUN
admet-628	654	19	)	)	PUNCT
admet-628	654	20	gtc	gtc	PROPN
admet-628	654	21	gtc	gtc	PROPN
admet-628	654	22	gt	gt	PROPN
admet-628	654	23	gt	gt	PROPN
admet-628	654	24	bac	bac	PROPN
admet-628	654	25	gtc	gtc	PROPN
admet-628	655	1	d	d	PROPN
admet-628	656	1	d	d	PROPN
admet-628	656	2	c	c	NOUN
admet-628	656	3	c	c	NOUN
admet-628	656	4	v	v	NOUN
admet-628	656	5	q	q	X
admet-628	656	6	c	c	NOUN
admet-628	656	7	t	t	NOUN
admet-628	656	8	r	r	NOUN
admet-628	656	9			NOUN
admet-628	656	10			NOUN
admet-628	656	11			PROPN
admet-628	656	12			PROPN
admet-628	656	13			CCONJ
admet-628	657	1			ADJ
admet-628	657	2			NOUN
admet-628	657	3	(	(	PUNCT
admet-628	657	4	10b	10b	NOUN
admet-628	657	5	)	)	PUNCT
admet-628	657	6	where	where	SCONJ
admet-628	657	7	,	,	PUNCT
admet-628	657	8	kf	kf	PROPN
admet-628	657	9	is	be	AUX
admet-628	657	10	the	the	DET
admet-628	657	11	fecal	fecal	ADJ
admet-628	657	12	excretion	excretion	NOUN
admet-628	657	13	rate	rate	NOUN
admet-628	657	14	constant	constant	ADJ
admet-628	657	15	;	;	PUNCT
admet-628	657	16	vmax	vmax	PROPN
admet-628	657	17	and	and	CCONJ
admet-628	657	18	km	km	PROPN
admet-628	657	19	are	be	AUX
admet-628	657	20	the	the	DET
admet-628	657	21	maximum	maximum	ADJ
admet-628	657	22	metabolic	metabolic	NOUN
admet-628	657	23	rate	rate	NOUN
admet-628	657	24	for	for	ADP
admet-628	657	25	op	op	NOUN
admet-628	657	26	and	and	CCONJ
admet-628	657	27	the	the	DET
admet-628	657	28	constant	constant	ADJ
admet-628	657	29	respectively	respectively	ADV
admet-628	657	30	;	;	PUNCT
admet-628	657	31	r	r	NOUN
admet-628	657	32	=	=	SYM
admet-628	657	33	mwoc	mwoc	PROPN
admet-628	657	34	/mwop	/mwop	NOUN
admet-628	657	35	,	,	PUNCT
admet-628	657	36	mw	mw	X
admet-628	657	37	is	be	AUX
admet-628	657	38	molecular	molecular	ADJ
admet-628	657	39	weight	weight	NOUN
admet-628	657	40	;	;	PUNCT
admet-628	657	41	rao	rao	NOUN
admet-628	657	42	is	be	AUX
admet-628	657	43	op	op	NOUN
admet-628	657	44	input	input	NOUN
admet-628	657	45	rate	rate	NOUN
admet-628	657	46	into	into	ADP
admet-628	657	47	the	the	DET
admet-628	657	48	blood	blood	NOUN
admet-628	657	49	from	from	ADP
admet-628	657	50	the	the	DET
admet-628	657	51	gut	gut	NOUN
admet-628	657	52	,	,	PUNCT
admet-628	657	53	rao	rao	NOUN
admet-628	657	54	=	=	SYM
admet-628	657	55	ka(f)(dose)e	ka(f)(dose)e	PROPN
admet-628	657	56	-	-	PUNCT
admet-628	657	57	ka(t	ka(t	NOUN
admet-628	657	58	-	-	PUNCT
admet-628	657	59	tlag	tlag	NOUN
admet-628	657	60	)	)	PUNCT
admet-628	657	61	,	,	PUNCT
admet-628	657	62	where	where	SCONJ
admet-628	657	63	ka	ka	PROPN
admet-628	657	64	represents	represent	VERB
admet-628	657	65	the	the	DET
admet-628	657	66	absorption	absorption	NOUN
admet-628	657	67	rate	rate	NOUN
admet-628	657	68	constant	constant	ADJ
admet-628	657	69	of	of	ADP
admet-628	657	70	op	op	NOUN
admet-628	657	71	,	,	PUNCT
admet-628	657	72	dose	dose	NOUN
admet-628	657	73	represents	represent	VERB
admet-628	657	74	op	op	NOUN
admet-628	657	75	dosage	dosage	NOUN
admet-628	657	76	,	,	PUNCT
admet-628	657	77	f	f	PROPN
admet-628	657	78	represents	represent	VERB
admet-628	657	79	the	the	DET
admet-628	657	80	apparent	apparent	ADJ
admet-628	657	81	or	or	CCONJ
admet-628	657	82	empirical	empirical	ADJ
admet-628	657	83	bioavailability	bioavailability	NOUN
admet-628	657	84	factor	factor	NOUN
admet-628	657	85	,	,	PUNCT
admet-628	657	86	and	and	CCONJ
admet-628	657	87	tlag	tlag	NOUN
admet-628	657	88	represents	represent	VERB
admet-628	657	89	the	the	DET
admet-628	657	90	lag	lag	NOUN
admet-628	657	91	times	time	NOUN
admet-628	657	92	for	for	ADP
admet-628	657	93	absorption	absorption	NOUN
admet-628	657	94	;	;	PUNCT
admet-628	657	95	kf	kf	PROPN
admet-628	657	96	is	be	AUX
admet-628	657	97	the	the	DET
admet-628	657	98	fecal	fecal	ADJ
admet-628	657	99	excretion	excretion	NOUN
admet-628	657	100	rate	rate	NOUN
admet-628	657	101	constant	constant	ADJ
admet-628	657	102	;	;	PUNCT
admet-628	657	103	clp	clp	PROPN
admet-628	657	104	and	and	CCONJ
admet-628	657	105	clc	clc	PROPN
admet-628	657	106	are	be	AUX
admet-628	657	107	the	the	DET
admet-628	657	108	renal	renal	ADJ
admet-628	657	109	clearance	clearance	NOUN
admet-628	657	110	for	for	ADP
admet-628	657	111	op	op	NOUN
admet-628	657	112	and	and	CCONJ
admet-628	657	113	oc	oc	NOUN
admet-628	657	114	,	,	PUNCT
admet-628	657	115	respectively	respectively	ADV
admet-628	657	116	.	.	PUNCT
admet-628	658	1	©	©	NOUN
admet-628	658	2	2019	2019	NUM
admet-628	658	3	by	by	ADP
admet-628	658	4	the	the	DET
admet-628	658	5	authors	author	NOUN
admet-628	658	6	;	;	PUNCT
admet-628	658	7	licensee	licensee	PROPN
admet-628	658	8	iapc	iapc	PROPN
admet-628	658	9	,	,	PUNCT
admet-628	658	10	zagreb	zagreb	PROPN
admet-628	658	11	,	,	PUNCT
admet-628	658	12	croatia	croatia	PROPN
admet-628	658	13	.	.	PUNCT
admet-628	659	1	this	this	DET
admet-628	659	2	article	article	NOUN
admet-628	659	3	is	be	AUX
admet-628	659	4	an	an	DET
admet-628	659	5	open	open	ADJ
admet-628	659	6	-	-	PUNCT
admet-628	659	7	access	access	NOUN
admet-628	659	8	article	article	NOUN
admet-628	659	9	distributed	distribute	VERB
admet-628	659	10	under	under	ADP
admet-628	659	11	the	the	DET
admet-628	659	12	terms	term	NOUN
admet-628	659	13	and	and	CCONJ
admet-628	659	14	conditions	condition	NOUN
admet-628	659	15	of	of	ADP
admet-628	659	16	the	the	DET
admet-628	659	17	creative	creative	ADJ
admet-628	659	18	commons	common	NOUN
admet-628	659	19	attribution	attribution	NOUN
admet-628	659	20	license	license	NOUN
admet-628	659	21	(	(	PUNCT
admet-628	659	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-628	659	23	)	)	PUNCT
admet-628	659	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN