id	sid	tid	token	lemma	pos
admet-648	1	1	validated	validate	VERB
admet-648	1	2	lc	lc	PROPN
admet-648	1	3	-	-	PUNCT
admet-648	1	4	esi	esi	PROPN
admet-648	1	5	-	-	PUNCT
admet-648	1	6	ms	ms	ADJ
admet-648	1	7	/	/	SYM
admet-648	1	8	ms	ms	PROPN
admet-648	1	9	method	method	NOUN
admet-648	1	10	for	for	ADP
admet-648	1	11	the	the	DET
admet-648	1	12	determination	determination	NOUN
admet-648	1	13	of	of	ADP
admet-648	1	14	ivosidenib	ivosidenib	NOUN
admet-648	1	15	in	in	ADP
admet-648	1	16	10	10	NUM
admet-648	1	17	µl	µl	ADP
admet-648	1	18	mice	mice	NOUN
admet-648	1	19	plasma	plasma	NOUN
admet-648	1	20	:	:	PUNCT
admet-648	1	21	application	application	NOUN
admet-648	1	22	to	to	ADP
admet-648	1	23	a	a	DET
admet-648	1	24	pharmacokinetic	pharmacokinetic	ADJ
admet-648	1	25	study	study	NOUN
admet-648	1	26	doi	doi	NOUN
admet-648	1	27	:	:	PUNCT
admet-648	1	28	10.5599	10.5599	NUM
admet-648	1	29	/	/	SYM
admet-648	1	30	admet.648	admet.648	PROPN
admet-648	1	31	131	131	NUM
admet-648	1	32	admet	admet	PROPN
admet-648	1	33	&	&	CCONJ
admet-648	1	34	dmpk	dmpk	PROPN
admet-648	1	35	7(2	7(2	NUM
admet-648	1	36	)	)	PUNCT
admet-648	1	37	(	(	PUNCT
admet-648	1	38	2019	2019	NUM
admet-648	1	39	)	)	PUNCT
admet-648	1	40	131	131	NUM
admet-648	1	41	-	-	SYM
admet-648	1	42	139	139	NUM
admet-648	1	43	;	;	PUNCT
admet-648	1	44	doi	doi	NOUN
admet-648	1	45	:	:	PUNCT
admet-648	1	46	http://dx.doi.org/10.5599/admet.648	http://dx.doi.org/10.5599/admet.648	NOUN
admet-648	1	47	open	open	ADJ
admet-648	1	48	access	access	NOUN
admet-648	1	49	:	:	PUNCT
admet-648	1	50	issn	issn	PROPN
admet-648	1	51	:	:	PUNCT
admet-648	1	52	1848	1848	NUM
admet-648	1	53	-	-	SYM
admet-648	1	54	7718	7718	NUM
admet-648	1	55	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-648	1	56	original	original	ADJ
admet-648	1	57	scientific	scientific	ADJ
admet-648	1	58	paper	paper	NOUN
admet-648	1	59	validated	validate	VERB
admet-648	1	60	lc	lc	PROPN
admet-648	1	61	-	-	PUNCT
admet-648	1	62	esi	esi	PROPN
admet-648	1	63	-	-	PUNCT
admet-648	1	64	ms	ms	ADJ
admet-648	1	65	/	/	SYM
admet-648	1	66	ms	ms	PROPN
admet-648	1	67	method	method	NOUN
admet-648	1	68	for	for	ADP
admet-648	1	69	the	the	DET
admet-648	1	70	determination	determination	NOUN
admet-648	1	71	of	of	ADP
admet-648	1	72	ivosidenib	ivosidenib	NOUN
admet-648	1	73	in	in	ADP
admet-648	1	74	10	10	NUM
admet-648	1	75	µl	µl	ADP
admet-648	1	76	mice	mice	NOUN
admet-648	1	77	plasma	plasma	NOUN
admet-648	1	78	:	:	PUNCT
admet-648	1	79	application	application	NOUN
admet-648	1	80	to	to	ADP
admet-648	1	81	a	a	DET
admet-648	1	82	pharmacokinetic	pharmacokinetic	ADJ
admet-648	1	83	study	study	NOUN
admet-648	1	84	sreekanth	sreekanth	PROPN
admet-648	1	85	dittakavi1,2	dittakavi1,2	PROPN
admet-648	1	86	,	,	PUNCT
admet-648	1	87	rakesh	rakesh	PROPN
admet-648	1	88	kumar	kumar	PROPN
admet-648	1	89	jat2	jat2	PROPN
admet-648	1	90	,	,	PUNCT
admet-648	1	91	sadanand	sadanand	X
admet-648	1	92	rangnathrao	rangnathrao	PROPN
admet-648	1	93	mallurwar1	mallurwar1	PROPN
admet-648	1	94	,	,	PUNCT
admet-648	1	95	ravi	ravi	PROPN
admet-648	1	96	kumar	kumar	PROPN
admet-648	1	97	jairam1	jairam1	PROPN
admet-648	1	98	,	,	PUNCT
admet-648	1	99	ramesh	ramesh	PROPN
admet-648	1	100	mullangi1	mullangi1	PROPN
admet-648	1	101	*	*	PROPN
admet-648	1	102	1	1	NUM
admet-648	1	103	drug	drug	NOUN
admet-648	1	104	metabolism	metabolism	NOUN
admet-648	1	105	and	and	CCONJ
admet-648	1	106	pharmacokinetics	pharmacokinetic	NOUN
admet-648	1	107	,	,	PUNCT
admet-648	1	108	jubilant	jubilant	ADJ
admet-648	1	109	biosys	biosy	NOUN
admet-648	1	110	,	,	PUNCT
admet-648	1	111	industrial	industrial	ADJ
admet-648	1	112	suburb	suburb	NOUN
admet-648	1	113	,	,	PUNCT
admet-648	1	114	yeshwanthpur	yeshwanthpur	PROPN
admet-648	1	115	,	,	PUNCT
admet-648	1	116	bangalore-560	bangalore-560	PROPN
admet-648	1	117	022	022	NUM
admet-648	1	118	,	,	PUNCT
admet-648	1	119	india	india	PROPN
admet-648	1	120	2	2	NUM
admet-648	1	121	institute	institute	PROPN
admet-648	1	122	of	of	ADP
admet-648	1	123	pharmacy	pharmacy	NOUN
admet-648	1	124	,	,	PUNCT
admet-648	1	125	shri	shri	PROPN
admet-648	1	126	jagdish	jagdish	PROPN
admet-648	1	127	prasad	prasad	PROPN
admet-648	1	128	jhabarmal	jhabarmal	PROPN
admet-648	1	129	tibrewala	tibrewala	PROPN
admet-648	1	130	university	university	PROPN
admet-648	1	131	,	,	PUNCT
admet-648	1	132	jhunjhunu	jhunjhunu	NOUN
admet-648	1	133	-	-	PUNCT
admet-648	1	134	churu	churu	NOUN
admet-648	1	135	road	road	NOUN
admet-648	1	136	,	,	PUNCT
admet-648	1	137	chudela	chudela	PROPN
admet-648	1	138	,	,	PUNCT
admet-648	1	139	jhunjhunu-333001	jhunjhunu-333001	NOUN
admet-648	1	140	,	,	PUNCT
admet-648	1	141	rajasthan	rajasthan	NOUN
admet-648	1	142	*	*	PUNCT
admet-648	1	143	corresponding	correspond	VERB
admet-648	1	144	author	author	NOUN
admet-648	1	145	:	:	PUNCT
admet-648	1	146	e	e	NOUN
admet-648	1	147	-	-	NOUN
admet-648	1	148	mail	mail	NOUN
admet-648	1	149	:	:	PUNCT
admet-648	1	150	mullangi.ramesh@jubilantinnovation.com	mullangi.ramesh@jubilantinnovation.com	X
admet-648	1	151	;	;	PUNCT
admet-648	1	152	tel	tel	PROPN
admet-648	1	153	.	.	PUNCT
admet-648	1	154	:	:	PUNCT
admet-648	2	1	+91	+91	NOUN
admet-648	2	2	-	-	PUNCT
admet-648	2	3	80	80	NUM
admet-648	2	4	-	-	PUNCT
admet-648	2	5	66628339	66628339	NUM
admet-648	2	6	received	receive	VERB
admet-648	2	7	:	:	PUNCT
admet-648	2	8	december	december	PROPN
admet-648	2	9	18	18	NUM
admet-648	2	10	,	,	PUNCT
admet-648	2	11	2018	2018	NUM
admet-648	2	12	;	;	PUNCT
admet-648	2	13	revised	revise	VERB
admet-648	2	14	:	:	PUNCT
admet-648	2	15	february	february	PROPN
admet-648	2	16	04	04	NUM
admet-648	2	17	,	,	PUNCT
admet-648	2	18	2019	2019	NUM
admet-648	2	19	;	;	PUNCT
admet-648	2	20	available	available	ADJ
admet-648	2	21	online	online	NOUN
admet-648	2	22	:	:	PUNCT
admet-648	2	23	march	march	PROPN
admet-648	2	24	05	05	NUM
admet-648	2	25	,	,	PUNCT
admet-648	2	26	2019	2019	NUM
admet-648	2	27	abstract	abstract	ADV
admet-648	2	28	a	a	DET
admet-648	2	29	simple	simple	ADJ
admet-648	2	30	,	,	PUNCT
admet-648	2	31	selective	selective	ADJ
admet-648	2	32	and	and	CCONJ
admet-648	2	33	rapid	rapid	ADJ
admet-648	2	34	lc	lc	PROPN
admet-648	2	35	-	-	PUNCT
admet-648	2	36	esi	esi	PROPN
admet-648	2	37	-	-	PUNCT
admet-648	2	38	ms	ms	ADJ
admet-648	2	39	/	/	SYM
admet-648	2	40	ms	ms	PROPN
admet-648	2	41	method	method	NOUN
admet-648	2	42	has	have	AUX
admet-648	2	43	been	be	AUX
admet-648	2	44	developed	develop	VERB
admet-648	2	45	and	and	CCONJ
admet-648	2	46	validated	validate	VERB
admet-648	2	47	for	for	ADP
admet-648	2	48	the	the	DET
admet-648	2	49	quantification	quantification	NOUN
admet-648	2	50	of	of	ADP
admet-648	2	51	ivosidenib	ivosidenib	NOUN
admet-648	2	52	in	in	ADP
admet-648	2	53	mice	mice	NOUN
admet-648	2	54	plasma	plasma	NOUN
admet-648	2	55	using	use	VERB
admet-648	2	56	warfarin	warfarin	NOUN
admet-648	2	57	as	as	ADP
admet-648	2	58	an	an	DET
admet-648	2	59	internal	internal	ADJ
admet-648	2	60	standard	standard	NOUN
admet-648	2	61	(	(	PUNCT
admet-648	2	62	i.s	i.s	PROPN
admet-648	2	63	.	.	PROPN
admet-648	2	64	)	)	PUNCT
admet-648	3	1	as	as	ADP
admet-648	3	2	per	per	ADP
admet-648	3	3	regulatory	regulatory	ADJ
admet-648	3	4	guideline	guideline	NOUN
admet-648	3	5	.	.	PUNCT
admet-648	4	1	sample	sample	NOUN
admet-648	4	2	preparation	preparation	NOUN
admet-648	4	3	was	be	AUX
admet-648	4	4	accomplished	accomplish	VERB
admet-648	4	5	through	through	ADP
admet-648	4	6	a	a	DET
admet-648	4	7	simple	simple	ADJ
admet-648	4	8	protein	protein	NOUN
admet-648	4	9	precipitation	precipitation	NOUN
admet-648	4	10	process	process	NOUN
admet-648	4	11	.	.	PUNCT
admet-648	5	1	chromatography	chromatography	NOUN
admet-648	5	2	of	of	ADP
admet-648	5	3	ivosidenib	ivosidenib	NOUN
admet-648	5	4	and	and	CCONJ
admet-648	5	5	the	the	DET
admet-648	5	6	i.s	i.s	PROPN
admet-648	5	7	.	.	PROPN
admet-648	5	8	was	be	AUX
admet-648	5	9	achieved	achieve	VERB
admet-648	5	10	on	on	ADP
admet-648	5	11	an	an	DET
admet-648	5	12	atlantis	atlantis	PROPN
admet-648	5	13	dc18	dc18	PROPN
admet-648	5	14	column	column	NOUN
admet-648	5	15	using	use	VERB
admet-648	5	16	an	an	DET
admet-648	5	17	isocratic	isocratic	ADJ
admet-648	5	18	mobile	mobile	NOUN
admet-648	5	19	phase	phase	NOUN
admet-648	5	20	comprising	comprise	VERB
admet-648	5	21	0.2	0.2	NUM
admet-648	5	22	%	%	NOUN
admet-648	5	23	formic	formic	ADJ
admet-648	5	24	acid	acid	NOUN
admet-648	5	25	in	in	ADP
admet-648	5	26	water	water	NOUN
admet-648	5	27	and	and	CCONJ
admet-648	5	28	acetonitrile	acetonitrile	NOUN
admet-648	5	29	(	(	PUNCT
admet-648	5	30	25:75	25:75	NUM
admet-648	5	31	,	,	PUNCT
admet-648	5	32	v	v	NOUN
admet-648	5	33	/	/	SYM
admet-648	5	34	v	v	NOUN
admet-648	5	35	)	)	PUNCT
admet-648	5	36	delivered	deliver	VERB
admet-648	5	37	at	at	ADP
admet-648	5	38	a	a	DET
admet-648	5	39	flow	flow	NOUN
admet-648	5	40	rate	rate	NOUN
admet-648	5	41	of	of	ADP
admet-648	5	42	1.0	1.0	NUM
admet-648	5	43	ml	ml	NOUN
admet-648	5	44	/	/	SYM
admet-648	5	45	min	min	PROPN
admet-648	5	46	.	.	PROPN
admet-648	5	47	lc	lc	PROPN
admet-648	5	48	-	-	PUNCT
admet-648	5	49	ms	ms	PROPN
admet-648	5	50	/	/	PROPN
admet-648	5	51	ms	ms	PROPN
admet-648	5	52	was	be	AUX
admet-648	5	53	operated	operate	VERB
admet-648	5	54	under	under	ADP
admet-648	5	55	the	the	DET
admet-648	5	56	multiple	multiple	ADJ
admet-648	5	57	reaction	reaction	NOUN
admet-648	5	58	-	-	PUNCT
admet-648	5	59	monitoring	monitor	VERB
admet-648	5	60	mode	mode	NOUN
admet-648	5	61	(	(	PUNCT
admet-648	5	62	mrm	mrm	PROPN
admet-648	5	63	)	)	PUNCT
admet-648	5	64	using	use	VERB
admet-648	5	65	the	the	DET
admet-648	5	66	electrospray	electrospray	ADJ
admet-648	5	67	ionization	ionization	NOUN
admet-648	5	68	technique	technique	NOUN
admet-648	5	69	in	in	ADP
admet-648	5	70	positive	positive	ADJ
admet-648	5	71	ion	ion	NOUN
admet-648	5	72	mode	mode	NOUN
admet-648	5	73	and	and	CCONJ
admet-648	5	74	the	the	DET
admet-648	5	75	transitions	transition	NOUN
admet-648	5	76	of	of	ADP
admet-648	5	77	m	m	PROPN
admet-648	5	78	/	/	SYM
admet-648	5	79	z	z	PROPN
admet-648	5	80	583.1→186.1	583.1→186.1	NUM
admet-648	5	81	and	and	CCONJ
admet-648	5	82	m	m	PROPN
admet-648	5	83	/	/	SYM
admet-648	5	84	z	z	PROPN
admet-648	5	85	309.2→251.3	309.2→251.3	PROPN
admet-648	5	86	were	be	AUX
admet-648	5	87	used	use	VERB
admet-648	5	88	to	to	PART
admet-648	5	89	quantitate	quantitate	VERB
admet-648	5	90	ivosidenib	ivosidenib	NOUN
admet-648	5	91	and	and	CCONJ
admet-648	5	92	the	the	DET
admet-648	5	93	i.s	i.s	PROPN
admet-648	5	94	,	,	PUNCT
admet-648	5	95	respectively	respectively	ADV
admet-648	5	96	.	.	PUNCT
admet-648	6	1	the	the	DET
admet-648	6	2	total	total	ADJ
admet-648	6	3	chromatographic	chromatographic	ADJ
admet-648	6	4	run	run	NOUN
admet-648	6	5	time	time	NOUN
admet-648	6	6	was	be	AUX
admet-648	6	7	2.0	2.0	NUM
admet-648	6	8	min	min	NOUN
admet-648	6	9	.	.	PROPN
admet-648	6	10	linearity	linearity	PROPN
admet-648	6	11	was	be	AUX
admet-648	6	12	established	establish	VERB
admet-648	6	13	in	in	ADP
admet-648	6	14	the	the	DET
admet-648	6	15	concentration	concentration	NOUN
admet-648	6	16	range	range	NOUN
admet-648	6	17	of	of	ADP
admet-648	6	18	1.10	1.10	NUM
admet-648	6	19	-	-	PUNCT
admet-648	6	20	3293	3293	NUM
admet-648	6	21	ng	ng	NOUN
admet-648	6	22	/	/	SYM
admet-648	6	23	ml	ml	PROPN
admet-648	7	1	(	(	PUNCT
admet-648	7	2	r	r	NOUN
admet-648	7	3	2	2	NUM
admet-648	7	4	>	>	NOUN
admet-648	7	5	0.99	0.99	NUM
admet-648	7	6	)	)	PUNCT
admet-648	7	7	.	.	PUNCT
admet-648	8	1	the	the	DET
admet-648	8	2	intraand	intraand	NOUN
admet-648	8	3	inter	inter	ADJ
admet-648	8	4	-	-	ADJ
admet-648	8	5	day	day	NOUN
admet-648	8	6	accuracy	accuracy	NOUN
admet-648	8	7	and	and	CCONJ
admet-648	8	8	precision	precision	NOUN
admet-648	8	9	for	for	ADP
admet-648	8	10	ivosidenib	ivosidenib	NOUN
admet-648	8	11	in	in	ADP
admet-648	8	12	mice	mice	NOUN
admet-648	8	13	plasma	plasma	NOUN
admet-648	8	14	were	be	AUX
admet-648	8	15	in	in	ADP
admet-648	8	16	the	the	DET
admet-648	8	17	range	range	NOUN
admet-648	8	18	of	of	ADP
admet-648	8	19	5.72	5.72	NUM
admet-648	8	20	-	-	SYM
admet-648	8	21	9.91	9.91	NUM
admet-648	8	22	and	and	CCONJ
admet-648	8	23	5.90	5.90	NUM
admet-648	8	24	-	-	SYM
admet-648	8	25	10.7	10.7	NUM
admet-648	8	26	%	%	NOUN
admet-648	8	27	,	,	PUNCT
admet-648	8	28	respectively	respectively	ADV
admet-648	8	29	.	.	PUNCT
admet-648	9	1	ivosidenib	ivosidenib	NOUN
admet-648	9	2	was	be	AUX
admet-648	9	3	found	find	VERB
admet-648	9	4	to	to	PART
admet-648	9	5	be	be	AUX
admet-648	9	6	stable	stable	ADJ
admet-648	9	7	on	on	ADP
admet-648	9	8	bench	bench	NOUN
admet-648	9	9	-	-	PUNCT
admet-648	9	10	top	top	NOUN
admet-648	9	11	for	for	ADP
admet-648	9	12	6	6	NUM
admet-648	9	13	h	h	NOUN
admet-648	9	14	,	,	PUNCT
admet-648	9	15	up	up	ADP
admet-648	9	16	to	to	PART
admet-648	9	17	three	three	NUM
admet-648	9	18	freeze	freeze	ADJ
admet-648	9	19	-	-	PUNCT
admet-648	9	20	thaw	thaw	NOUN
admet-648	9	21	cycles	cycle	NOUN
admet-648	9	22	,	,	PUNCT
admet-648	9	23	in	in	ADP
admet-648	9	24	in	in	ADP
admet-648	9	25	-	-	PUNCT
admet-648	9	26	injector	injector	NOUN
admet-648	9	27	for	for	ADP
admet-648	9	28	24	24	NUM
admet-648	9	29	h	h	NOUN
admet-648	9	30	and	and	CCONJ
admet-648	9	31	for	for	ADP
admet-648	9	32	one	one	NUM
admet-648	9	33	month	month	NOUN
admet-648	9	34	at	at	ADP
admet-648	9	35	-80	-80	NOUN
admet-648	9	36	°	°	NOUN
admet-648	9	37	c	c	NOUN
admet-648	9	38	.	.	PUNCT
admet-648	10	1	the	the	DET
admet-648	10	2	applicability	applicability	NOUN
admet-648	10	3	of	of	ADP
admet-648	10	4	the	the	DET
admet-648	10	5	validated	validate	VERB
admet-648	10	6	method	method	NOUN
admet-648	10	7	has	have	AUX
admet-648	10	8	been	be	AUX
admet-648	10	9	demonstrated	demonstrate	VERB
admet-648	10	10	in	in	ADP
admet-648	10	11	a	a	DET
admet-648	10	12	mice	mice	NOUN
admet-648	10	13	pharmacokinetic	pharmacokinetic	ADJ
admet-648	10	14	study	study	NOUN
admet-648	10	15	.	.	PUNCT
admet-648	11	1	following	follow	VERB
admet-648	11	2	intravenous	intravenous	ADJ
admet-648	11	3	(	(	PUNCT
admet-648	11	4	2	2	NUM
admet-648	11	5	mg	mg	PROPN
admet-648	11	6	/	/	SYM
admet-648	11	7	kg	kg	NOUN
admet-648	11	8	)	)	PUNCT
admet-648	11	9	and	and	CCONJ
admet-648	11	10	oral	oral	ADJ
admet-648	11	11	(	(	PUNCT
admet-648	11	12	5	5	NUM
admet-648	11	13	mg	mg	PROPN
admet-648	11	14	/	/	SYM
admet-648	11	15	kg	kg	PROPN
admet-648	11	16	)	)	PUNCT
admet-648	11	17	administration	administration	NOUN
admet-648	11	18	of	of	ADP
admet-648	11	19	ivosidenib	ivosidenib	NOUN
admet-648	11	20	to	to	ADP
admet-648	11	21	mice	mouse	NOUN
admet-648	11	22	,	,	PUNCT
admet-648	11	23	concentrations	concentration	NOUN
admet-648	11	24	were	be	AUX
admet-648	11	25	quantifiable	quantifiable	ADJ
admet-648	11	26	up	up	ADP
admet-648	11	27	to	to	ADP
admet-648	11	28	24	24	NUM
admet-648	11	29	and	and	CCONJ
admet-648	11	30	48	48	NUM
admet-648	11	31	h	h	NOUN
admet-648	11	32	,	,	PUNCT
admet-648	11	33	respectively	respectively	ADV
admet-648	11	34	.	.	PUNCT
admet-648	12	1	the	the	DET
admet-648	12	2	bioavailability	bioavailability	NOUN
admet-648	12	3	was	be	AUX
admet-648	12	4	61	61	NUM
admet-648	12	5	%	%	NOUN
admet-648	12	6	.	.	PUNCT
admet-648	13	1	keywords	keyword	NOUN
admet-648	13	2	ivosidenib	ivosidenib	NOUN
admet-648	13	3	;	;	PUNCT
admet-648	13	4	lc	lc	PROPN
admet-648	13	5	-	-	PUNCT
admet-648	13	6	ms	ms	PROPN
admet-648	13	7	/	/	SYM
admet-648	13	8	ms	ms	PROPN
admet-648	13	9	;	;	PUNCT
admet-648	13	10	method	method	NOUN
admet-648	13	11	validation	validation	NOUN
admet-648	13	12	;	;	PUNCT
admet-648	13	13	mice	mice	NOUN
admet-648	13	14	plasma	plasma	NOUN
admet-648	13	15	;	;	PUNCT
admet-648	13	16	pharmacokinetics	pharmacokinetic	NOUN
admet-648	13	17	;	;	PUNCT
admet-648	13	18	bioavailability	bioavailability	NOUN
admet-648	13	19	introduction	introduction	NOUN
admet-648	13	20	isocitrate	isocitrate	ADJ
admet-648	13	21	dehydrogenase	dehydrogenase	NOUN
admet-648	13	22	isoforms	isoform	NOUN
admet-648	13	23	(	(	PUNCT
admet-648	13	24	idh1	idh1	NOUN
admet-648	13	25	and	and	CCONJ
admet-648	13	26	idh2/3	idh2/3	PROPN
admet-648	13	27	located	locate	VERB
admet-648	13	28	in	in	ADP
admet-648	13	29	cytoplasm	cytoplasm	NOUN
admet-648	13	30	and	and	CCONJ
admet-648	13	31	mitochondria	mitochondria	NOUN
admet-648	13	32	,	,	PUNCT
admet-648	13	33	respectively	respectively	ADV
admet-648	13	34	)	)	PUNCT
admet-648	13	35	play	play	VERB
admet-648	13	36	a	a	DET
admet-648	13	37	key	key	ADJ
admet-648	13	38	role	role	NOUN
admet-648	13	39	in	in	ADP
admet-648	13	40	normal	normal	ADJ
admet-648	13	41	cell	cell	NOUN
admet-648	13	42	growth	growth	NOUN
admet-648	13	43	and	and	CCONJ
admet-648	13	44	regulation	regulation	NOUN
admet-648	13	45	.	.	PUNCT
admet-648	14	1	all	all	DET
admet-648	14	2	three	three	NUM
admet-648	14	3	isoforms	isoform	NOUN
admet-648	14	4	are	be	AUX
admet-648	14	5	responsible	responsible	ADJ
admet-648	14	6	for	for	ADP
admet-648	14	7	the	the	DET
admet-648	14	8	production	production	NOUN
admet-648	14	9	of	of	ADP
admet-648	14	10	nicotinamide	nicotinamide	NOUN
admet-648	14	11	adenine	adenine	ADJ
admet-648	14	12	dinucleotide	dinucleotide	NOUN
admet-648	14	13	phosphate	phosphate	NOUN
admet-648	14	14	(	(	PUNCT
admet-648	14	15	nadph	nadph	PROPN
admet-648	14	16	)	)	PUNCT
admet-648	14	17	from	from	ADP
admet-648	14	18	nadp+	nadp+	NOUN
admet-648	14	19	by	by	ADP
admet-648	14	20	catalyzing	catalyze	VERB
admet-648	14	21	the	the	DET
admet-648	14	22	oxidative	oxidative	ADJ
admet-648	14	23	decarboxylation	decarboxylation	NOUN
admet-648	14	24	of	of	ADP
admet-648	14	25	isocitrate	isocitrate	NOUN
admet-648	14	26	to	to	ADP
admet-648	14	27	α	α	NOUN
admet-648	14	28	-	-	PUNCT
admet-648	14	29	ketoglutarate	ketoglutarate	NOUN
admet-648	14	30	(	(	PUNCT
admet-648	14	31	α	α	NOUN
admet-648	14	32	-	-	PUNCT
admet-648	14	33	kg	kg	NOUN
admet-648	14	34	)	)	PUNCT
admet-648	15	1	[	[	X
admet-648	15	2	1	1	NUM
admet-648	15	3	]	]	PUNCT
admet-648	15	4	.	.	PUNCT
admet-648	16	1	recent	recent	ADJ
admet-648	16	2	investigations	investigation	NOUN
admet-648	16	3	discovered	discover	VERB
admet-648	16	4	that	that	SCONJ
admet-648	16	5	idh1/2	idh1/2	PROPN
admet-648	16	6	mutations	mutation	NOUN
admet-648	16	7	in	in	ADP
admet-648	16	8	20	20	NUM
admet-648	16	9	%	%	NOUN
admet-648	16	10	of	of	ADP
admet-648	16	11	acute	acute	ADJ
admet-648	16	12	myeloid	myeloid	NOUN
admet-648	16	13	leukemia	leukemia	NOUN
admet-648	16	14	(	(	PUNCT
admet-648	16	15	aml	aml	PROPN
admet-648	16	16	)	)	PUNCT
admet-648	16	17	population	population	NOUN
admet-648	16	18	and	and	CCONJ
admet-648	16	19	rarely	rarely	ADV
admet-648	16	20	in	in	ADP
admet-648	16	21	breast	breast	NOUN
admet-648	16	22	,	,	PUNCT
admet-648	16	23	lung	lung	NOUN
admet-648	16	24	and	and	CCONJ
admet-648	16	25	prostate	prostate	NOUN
admet-648	16	26	cancers	cancer	NOUN
admet-648	16	27	[	[	X
admet-648	16	28	2	2	NUM
admet-648	16	29	]	]	PUNCT
admet-648	16	30	.	.	PUNCT
admet-648	17	1	targeting	target	VERB
admet-648	17	2	mutant	mutant	NOUN
admet-648	17	3	idh1/2	idh1/2	PUNCT
admet-648	17	4	proved	prove	VERB
admet-648	17	5	to	to	PART
admet-648	17	6	be	be	AUX
admet-648	17	7	an	an	DET
admet-648	17	8	option	option	NOUN
admet-648	17	9	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-648	17	10	mailto:mullangi.ramesh@jubilantinnovation.com	mailto:mullangi.ramesh@jubilantinnovation.com	PROPN
admet-648	17	11	r.	r.	PROPN
admet-648	17	12	mullangi	mullangi	VERB
admet-648	17	13	et	et	PROPN
admet-648	17	14	al	al	PROPN
admet-648	17	15	.	.	PROPN
admet-648	17	16	admet	admet	PROPN
admet-648	17	17	&	&	CCONJ
admet-648	17	18	dmpk	dmpk	PROPN
admet-648	17	19	7(2	7(2	NUM
admet-648	17	20	)	)	PUNCT
admet-648	17	21	(	(	PUNCT
admet-648	17	22	2019	2019	NUM
admet-648	17	23	)	)	PUNCT
admet-648	17	24	131	131	NUM
admet-648	17	25	-	-	SYM
admet-648	17	26	139	139	NUM
admet-648	17	27	132	132	NUM
admet-648	17	28	for	for	ADP
admet-648	17	29	the	the	DET
admet-648	17	30	treatment	treatment	NOUN
admet-648	17	31	of	of	ADP
admet-648	17	32	aml	aml	NOUN
admet-648	17	33	as	as	ADP
admet-648	17	34	a	a	DET
admet-648	17	35	targeted	target	VERB
admet-648	17	36	therapy	therapy	NOUN
admet-648	17	37	alone	alone	ADV
admet-648	17	38	or	or	CCONJ
admet-648	17	39	in	in	ADP
admet-648	17	40	combination	combination	NOUN
admet-648	17	41	with	with	ADP
admet-648	17	42	other	other	ADJ
admet-648	17	43	antileukemic	antileukemic	ADJ
admet-648	17	44	agents	agent	NOUN
admet-648	17	45	[	[	X
admet-648	17	46	3	3	NUM
admet-648	17	47	]	]	PUNCT
admet-648	17	48	.	.	PUNCT
admet-648	18	1	ivosidenib	ivosidenib	PROPN
admet-648	18	2	(	(	PUNCT
admet-648	18	3	ag-120	ag-120	PROPN
admet-648	18	4	,	,	PUNCT
admet-648	18	5	tibsovo	tibsovo	PROPN
admet-648	18	6	®	®	NOUN
admet-648	18	7	;	;	PUNCT
admet-648	18	8	fig	fig	NOUN
admet-648	18	9	.	.	NOUN
admet-648	19	1	1	1	NUM
admet-648	19	2	)	)	PUNCT
admet-648	20	1	,	,	PUNCT
admet-648	20	2	is	be	AUX
admet-648	20	3	a	a	DET
admet-648	20	4	novel	novel	NOUN
admet-648	20	5	,	,	PUNCT
admet-648	20	6	first	first	ADJ
admet-648	20	7	-	-	PUNCT
admet-648	20	8	in	in	ADP
admet-648	20	9	-	-	PUNCT
admet-648	20	10	class	class	NOUN
admet-648	20	11	,	,	PUNCT
admet-648	20	12	oral	oral	ADJ
admet-648	20	13	small	small	ADJ
admet-648	20	14	molecule	molecule	NOUN
admet-648	20	15	,	,	PUNCT
admet-648	20	16	which	which	PRON
admet-648	20	17	selectively	selectively	ADV
admet-648	20	18	and	and	CCONJ
admet-648	20	19	reversibly	reversibly	ADV
admet-648	20	20	inhibits	inhibit	VERB
admet-648	20	21	midh1	midh1	NOUN
admet-648	20	22	(	(	PUNCT
admet-648	20	23	ic50	ic50	PROPN
admet-648	20	24	:	:	PUNCT
admet-648	20	25	12	12	NUM
admet-648	20	26	nm	nm	NOUN
admet-648	20	27	)	)	PUNCT
admet-648	20	28	without	without	ADP
admet-648	20	29	any	any	DET
admet-648	20	30	idh2	idh2	NOUN
admet-648	20	31	inhibition	inhibition	NOUN
admet-648	20	32	(	(	PUNCT
admet-648	20	33	at	at	ADP
admet-648	20	34	micromolar	micromolar	ADJ
admet-648	20	35	concentration	concentration	NOUN
admet-648	20	36	)	)	PUNCT
admet-648	20	37	along	along	ADP
admet-648	20	38	with	with	ADP
admet-648	20	39	good	good	ADJ
admet-648	20	40	cellular	cellular	ADJ
admet-648	20	41	potency	potency	NOUN
admet-648	20	42	.	.	PUNCT
admet-648	21	1	it	it	PRON
admet-648	21	2	showed	show	VERB
admet-648	21	3	tumor	tumor	NOUN
admet-648	21	4	regression	regression	NOUN
admet-648	21	5	in	in	ADP
admet-648	21	6	mice	mice	NOUN
admet-648	21	7	xenograft	xenograft	NOUN
admet-648	21	8	model	model	PROPN
admet-648	21	9	of	of	ADP
admet-648	21	10	idh	idh	NOUN
admet-648	21	11	-	-	PUNCT
admet-648	21	12	mutated	mutate	VERB
admet-648	21	13	aml	aml	NOUN
admet-648	21	14	at	at	ADP
admet-648	21	15	50	50	NUM
admet-648	21	16	and	and	CCONJ
admet-648	21	17	150	150	NUM
admet-648	21	18	mg	mg	NUM
admet-648	21	19	/	/	SYM
admet-648	21	20	kg	kg	PROPN
admet-648	21	21	doses	dose	NOUN
admet-648	21	22	[	[	X
admet-648	21	23	4	4	NUM
admet-648	21	24	]	]	PUNCT
admet-648	21	25	.	.	PUNCT
admet-648	22	1	recently	recently	ADV
admet-648	22	2	,	,	PUNCT
admet-648	22	3	fda	fda	PROPN
admet-648	22	4	approved	approve	VERB
admet-648	22	5	ivosidenib	ivosidenib	NOUN
admet-648	22	6	as	as	ADP
admet-648	22	7	an	an	DET
admet-648	22	8	orphan	orphan	NOUN
admet-648	22	9	drug	drug	NOUN
admet-648	22	10	for	for	ADP
admet-648	22	11	relapsed	relapse	VERB
admet-648	22	12	or	or	CCONJ
admet-648	22	13	refractory	refractory	NOUN
admet-648	22	14	idh1	idh1	PROPN
admet-648	22	15	mutant	mutant	ADJ
admet-648	22	16	aml	aml	PROPN
admet-648	22	17	patients	patient	NOUN
admet-648	22	18	as	as	SCONJ
admet-648	22	19	detected	detect	VERB
admet-648	22	20	by	by	ADP
admet-648	22	21	an	an	DET
admet-648	22	22	fda	fda	PROPN
admet-648	22	23	-	-	PUNCT
admet-648	22	24	approved	approve	VERB
admet-648	22	25	test	test	NOUN
admet-648	22	26	[	[	X
admet-648	22	27	5	5	NUM
admet-648	22	28	]	]	PUNCT
admet-648	22	29	.	.	PUNCT
admet-648	23	1	in	in	ADP
admet-648	23	2	humans	human	NOUN
admet-648	23	3	as	as	ADP
admet-648	23	4	a	a	DET
admet-648	23	5	monotherapy	monotherapy	NOUN
admet-648	23	6	it	it	PRON
admet-648	23	7	is	be	AUX
admet-648	23	8	administered	administer	VERB
admet-648	23	9	at	at	ADP
admet-648	23	10	a	a	DET
admet-648	23	11	daily	daily	ADJ
admet-648	23	12	dose	dose	NOUN
admet-648	23	13	of	of	ADP
admet-648	23	14	500	500	NUM
admet-648	23	15	mg	mg	NOUN
admet-648	23	16	.	.	PUNCT
admet-648	24	1	following	follow	VERB
admet-648	24	2	oral	oral	ADJ
admet-648	24	3	administration	administration	NOUN
admet-648	24	4	cmax	cmax	NOUN
admet-648	24	5	(	(	PUNCT
admet-648	24	6	maximum	maximum	ADJ
admet-648	24	7	concentration	concentration	NOUN
admet-648	24	8	in	in	ADP
admet-648	24	9	plasma	plasma	NOUN
admet-648	24	10	)	)	PUNCT
admet-648	24	11	attained	attain	VERB
admet-648	24	12	at	at	ADP
admet-648	24	13	~3	~3	NOUN
admet-648	24	14	h	h	PROPN
admet-648	24	15	(	(	PUNCT
admet-648	24	16	tmax	tmax	ADV
admet-648	24	17	)	)	PUNCT
admet-648	24	18	.	.	PUNCT
admet-648	25	1	it	it	PRON
admet-648	25	2	has	have	AUX
admet-648	25	3	shown	show	VERB
admet-648	25	4	less	less	ADJ
admet-648	25	5	than	than	SCONJ
admet-648	25	6	dose	dose	VERB
admet-648	25	7	proportional	proportional	ADJ
admet-648	25	8	increase	increase	NOUN
admet-648	25	9	in	in	ADP
admet-648	25	10	auc	auc	NOUN
admet-648	25	11	(	(	PUNCT
admet-648	25	12	area	area	NOUN
admet-648	25	13	under	under	ADP
admet-648	25	14	concentration	concentration	NOUN
admet-648	25	15	time	time	NOUN
admet-648	25	16	curve	curve	NOUN
admet-648	25	17	)	)	PUNCT
admet-648	25	18	and	and	CCONJ
admet-648	25	19	cmax	cmax	VERB
admet-648	25	20	from	from	ADP
admet-648	25	21	200	200	NUM
admet-648	25	22	-	-	SYM
admet-648	25	23	1200	1200	NUM
admet-648	25	24	mg	mg	NOUN
admet-648	25	25	.	.	PUNCT
admet-648	26	1	unchanged	unchanged	ADJ
admet-648	26	2	ivosidenib	ivosidenib	NOUN
admet-648	26	3	is	be	AUX
admet-648	26	4	majorly	majorly	ADV
admet-648	26	5	(	(	PUNCT
admet-648	26	6	92	92	NUM
admet-648	26	7	%	%	NOUN
admet-648	26	8	)	)	PUNCT
admet-648	26	9	seen	see	VERB
admet-648	26	10	in	in	ADP
admet-648	26	11	plasma	plasma	NOUN
admet-648	26	12	.	.	PUNCT
admet-648	27	1	ivosidenib	ivosidenib	PROPN
admet-648	27	2	is	be	AUX
admet-648	27	3	92	92	NUM
admet-648	27	4	-	-	SYM
admet-648	27	5	96	96	NUM
admet-648	27	6	%	%	NOUN
admet-648	27	7	bound	bind	VERB
admet-648	27	8	to	to	ADP
admet-648	27	9	plasma	plasma	NOUN
admet-648	27	10	proteins	protein	NOUN
admet-648	27	11	.	.	PUNCT
admet-648	28	1	cyp3a4	cyp3a4	PROPN
admet-648	28	2	mainly	mainly	ADV
admet-648	28	3	involved	involve	VERB
admet-648	28	4	in	in	ADP
admet-648	28	5	its	its	PRON
admet-648	28	6	metabolism	metabolism	NOUN
admet-648	28	7	(	(	PUNCT
admet-648	28	8	n	n	CCONJ
admet-648	28	9	-	-	PUNCT
admet-648	28	10	dealkylation	dealkylation	NOUN
admet-648	28	11	and	and	CCONJ
admet-648	28	12	hydrolysis	hydrolysis	NOUN
admet-648	28	13	)	)	PUNCT
admet-648	28	14	.	.	PUNCT
admet-648	29	1	it	it	PRON
admet-648	29	2	is	be	AUX
admet-648	29	3	eliminated	eliminate	VERB
admet-648	29	4	as	as	ADP
admet-648	29	5	parent	parent	NOUN
admet-648	29	6	up	up	ADP
admet-648	29	7	to	to	ADP
admet-648	29	8	67	67	NUM
admet-648	29	9	and	and	CCONJ
admet-648	29	10	10	10	NUM
admet-648	29	11	%	%	NOUN
admet-648	29	12	in	in	ADP
admet-648	29	13	the	the	DET
admet-648	29	14	feces	fece	NOUN
admet-648	29	15	and	and	CCONJ
admet-648	29	16	urine	urine	NOUN
admet-648	29	17	,	,	PUNCT
admet-648	29	18	respectively	respectively	ADV
admet-648	29	19	.	.	PUNCT
admet-648	30	1	the	the	DET
admet-648	30	2	oral	oral	ADJ
admet-648	30	3	bioavailability	bioavailability	NOUN
admet-648	30	4	was	be	AUX
admet-648	30	5	found	find	VERB
admet-648	30	6	to	to	PART
admet-648	30	7	be	be	AUX
admet-648	30	8	57	57	NUM
admet-648	30	9	%	%	NOUN
admet-648	31	1	[	[	X
admet-648	31	2	5	5	NUM
admet-648	31	3	]	]	PUNCT
admet-648	31	4	.	.	PUNCT
admet-648	32	1	lc	lc	PROPN
admet-648	32	2	-	-	PUNCT
admet-648	32	3	ms	ms	PROPN
admet-648	32	4	/	/	SYM
admet-648	32	5	ms	ms	PROPN
admet-648	32	6	is	be	AUX
admet-648	32	7	a	a	DET
admet-648	32	8	powerful	powerful	ADJ
admet-648	32	9	tool	tool	NOUN
admet-648	32	10	for	for	ADP
admet-648	32	11	rapid	rapid	ADJ
admet-648	32	12	quantitation	quantitation	NOUN
admet-648	32	13	of	of	ADP
admet-648	32	14	drugs	drug	NOUN
admet-648	32	15	in	in	ADP
admet-648	32	16	various	various	ADJ
admet-648	32	17	biological	biological	ADJ
admet-648	32	18	matrices	matrix	NOUN
admet-648	32	19	with	with	ADP
admet-648	32	20	great	great	ADJ
admet-648	32	21	accuracy	accuracy	NOUN
admet-648	32	22	and	and	CCONJ
admet-648	32	23	sensitivity	sensitivity	NOUN
admet-648	32	24	with	with	ADP
admet-648	32	25	a	a	DET
admet-648	32	26	shorter	short	ADJ
admet-648	32	27	run	run	NOUN
admet-648	32	28	time	time	NOUN
admet-648	32	29	.	.	PUNCT
admet-648	33	1	preclinical	preclinical	ADJ
admet-648	33	2	pharmacokinetics	pharmacokinetic	NOUN
admet-648	33	3	has	have	VERB
admet-648	33	4	a	a	DET
admet-648	33	5	great	great	ADJ
admet-648	33	6	influence	influence	NOUN
admet-648	33	7	on	on	ADP
admet-648	33	8	the	the	DET
admet-648	33	9	development	development	NOUN
admet-648	33	10	and	and	CCONJ
admet-648	33	11	investigation	investigation	NOUN
admet-648	33	12	of	of	ADP
admet-648	33	13	potential	potential	ADJ
admet-648	33	14	preclinical	preclinical	ADJ
admet-648	33	15	candidates	candidate	NOUN
admet-648	33	16	with	with	ADP
admet-648	33	17	better	well	ADJ
admet-648	33	18	advice	advice	NOUN
admet-648	33	19	for	for	ADP
admet-648	33	20	the	the	DET
admet-648	33	21	further	further	ADJ
admet-648	33	22	drug	drug	NOUN
admet-648	33	23	design	design	NOUN
admet-648	33	24	.	.	PUNCT
admet-648	34	1	pharmacokinetic	pharmacokinetic	ADJ
admet-648	34	2	studies	study	NOUN
admet-648	34	3	in	in	ADP
admet-648	34	4	preclinical	preclinical	ADJ
admet-648	34	5	species	specie	NOUN
admet-648	34	6	can	can	AUX
admet-648	34	7	both	both	PRON
admet-648	34	8	provide	provide	VERB
admet-648	34	9	toxicological	toxicological	ADJ
admet-648	34	10	and	and	CCONJ
admet-648	34	11	clinical	clinical	ADJ
admet-648	34	12	information	information	NOUN
admet-648	34	13	and	and	CCONJ
admet-648	34	14	direct	direct	ADJ
admet-648	34	15	optimization	optimization	NOUN
admet-648	34	16	of	of	ADP
admet-648	34	17	drug	drug	NOUN
admet-648	34	18	candidates	candidate	NOUN
admet-648	34	19	;	;	PUNCT
admet-648	34	20	as	as	ADP
admet-648	34	21	a	a	DET
admet-648	34	22	result	result	NOUN
admet-648	34	23	,	,	PUNCT
admet-648	34	24	they	they	PRON
admet-648	34	25	play	play	VERB
admet-648	34	26	necessary	necessary	ADJ
admet-648	34	27	parts	part	NOUN
admet-648	34	28	in	in	ADP
admet-648	34	29	drug	drug	NOUN
admet-648	34	30	discovery	discovery	NOUN
admet-648	34	31	and	and	CCONJ
admet-648	34	32	development	development	NOUN
admet-648	34	33	.	.	PUNCT
admet-648	35	1	to	to	ADP
admet-648	35	2	date	date	NOUN
admet-648	35	3	there	there	PRON
admet-648	35	4	is	be	VERB
admet-648	35	5	no	no	DET
admet-648	35	6	lc	lc	NOUN
admet-648	35	7	-	-	PUNCT
admet-648	35	8	ms	ms	PROPN
admet-648	35	9	/	/	SYM
admet-648	35	10	ms	ms	PROPN
admet-648	35	11	method	method	NOUN
admet-648	35	12	reported	report	VERB
admet-648	35	13	for	for	ADP
admet-648	35	14	quantification	quantification	NOUN
admet-648	35	15	of	of	ADP
admet-648	35	16	ivosidenib	ivosidenib	NOUN
admet-648	35	17	in	in	ADP
admet-648	35	18	any	any	DET
admet-648	35	19	biological	biological	ADJ
admet-648	35	20	matrix	matrix	NOUN
admet-648	35	21	.	.	PUNCT
admet-648	36	1	in	in	ADP
admet-648	36	2	this	this	DET
admet-648	36	3	paper	paper	NOUN
admet-648	36	4	,	,	PUNCT
admet-648	36	5	we	we	PRON
admet-648	36	6	are	be	AUX
admet-648	36	7	reporting	report	VERB
admet-648	36	8	the	the	DET
admet-648	36	9	development	development	NOUN
admet-648	36	10	and	and	CCONJ
admet-648	36	11	validation	validation	NOUN
admet-648	36	12	of	of	ADP
admet-648	36	13	a	a	DET
admet-648	36	14	sensitive	sensitive	ADJ
admet-648	36	15	,	,	PUNCT
admet-648	36	16	selective	selective	ADJ
admet-648	36	17	and	and	CCONJ
admet-648	36	18	rapid	rapid	ADJ
admet-648	36	19	lc	lc	PROPN
admet-648	36	20	-	-	PUNCT
admet-648	36	21	esi	esi	PROPN
admet-648	36	22	-	-	PUNCT
admet-648	36	23	ms	ms	ADJ
admet-648	36	24	/	/	SYM
admet-648	36	25	ms	ms	PROPN
admet-648	36	26	method	method	NOUN
admet-648	36	27	for	for	ADP
admet-648	36	28	quantitation	quantitation	NOUN
admet-648	36	29	of	of	ADP
admet-648	36	30	ivosidenib	ivosidenib	NOUN
admet-648	36	31	in	in	ADP
admet-648	36	32	mice	mice	NOUN
admet-648	36	33	plasma	plasma	NOUN
admet-648	36	34	.	.	PUNCT
admet-648	37	1	the	the	DET
admet-648	37	2	validated	validate	VERB
admet-648	37	3	method	method	NOUN
admet-648	37	4	was	be	AUX
admet-648	37	5	successfully	successfully	ADV
admet-648	37	6	used	use	VERB
admet-648	37	7	in	in	ADP
admet-648	37	8	a	a	DET
admet-648	37	9	mice	mice	NOUN
admet-648	37	10	pharmacokinetic	pharmacokinetic	ADJ
admet-648	37	11	study	study	NOUN
admet-648	37	12	following	follow	VERB
admet-648	37	13	intravenous	intravenous	ADJ
admet-648	37	14	and	and	CCONJ
admet-648	37	15	oral	oral	ADJ
admet-648	37	16	administration	administration	NOUN
admet-648	37	17	of	of	ADP
admet-648	37	18	ivosidenib	ivosidenib	NOUN
admet-648	37	19	at	at	ADP
admet-648	37	20	2.0	2.0	NUM
admet-648	37	21	and	and	CCONJ
admet-648	37	22	5.0	5.0	NUM
admet-648	37	23	mg	mg	NUM
admet-648	37	24	/	/	SYM
admet-648	37	25	kg	kg	PROPN
admet-648	37	26	dose	dose	NOUN
admet-648	37	27	,	,	PUNCT
admet-648	37	28	respectively	respectively	ADV
admet-648	37	29	.	.	PUNCT
admet-648	38	1	materials	material	NOUN
admet-648	38	2	and	and	CCONJ
admet-648	38	3	methods	method	NOUN
admet-648	38	4	materials	material	NOUN
admet-648	38	5	ivosidenib	ivosidenib	NOUN
admet-648	38	6	(	(	PUNCT
admet-648	38	7	purity	purity	NOUN
admet-648	38	8	:	:	PUNCT
admet-648	38	9	98	98	NOUN
admet-648	38	10	%	%	NOUN
admet-648	38	11	)	)	PUNCT
admet-648	38	12	was	be	AUX
admet-648	38	13	purchased	purchase	VERB
admet-648	38	14	from	from	ADP
admet-648	38	15	angene	angene	PROPN
admet-648	38	16	international	international	PROPN
admet-648	38	17	limited	limited	PROPN
admet-648	38	18	,	,	PUNCT
admet-648	38	19	england	england	PROPN
admet-648	38	20	,	,	PUNCT
admet-648	38	21	uk	uk	PROPN
admet-648	38	22	.	.	PROPN
admet-648	38	23	warfarin	warfarin	NOUN
admet-648	38	24	(	(	PUNCT
admet-648	38	25	i.s	i.s	INTJ
admet-648	38	26	;	;	PUNCT
admet-648	38	27	purity	purity	NOUN
admet-648	38	28	:	:	PUNCT
admet-648	38	29	98.7	98.7	NUM
admet-648	38	30	%	%	NOUN
admet-648	38	31	)	)	PUNCT
admet-648	38	32	was	be	AUX
admet-648	38	33	purchased	purchase	VERB
admet-648	38	34	from	from	ADP
admet-648	38	35	sigma	sigma	PROPN
admet-648	38	36	-	-	PUNCT
admet-648	38	37	aldrich	aldrich	PROPN
admet-648	38	38	,	,	PUNCT
admet-648	38	39	st	st	PROPN
admet-648	38	40	.	.	PROPN
admet-648	38	41	louis	louis	PROPN
admet-648	38	42	,	,	PUNCT
admet-648	38	43	usa	usa	PROPN
admet-648	38	44	.	.	PROPN
admet-648	38	45	lc	lc	PROPN
admet-648	38	46	-	-	PUNCT
admet-648	38	47	ms	ms	NOUN
admet-648	38	48	-	-	PUNCT
admet-648	38	49	grade	grade	NOUN
admet-648	38	50	acetonitrile	acetonitrile	NOUN
admet-648	38	51	and	and	CCONJ
admet-648	38	52	methanol	methanol	NOUN
admet-648	38	53	were	be	AUX
admet-648	38	54	purchased	purchase	VERB
admet-648	38	55	from	from	ADP
admet-648	38	56	jt	jt	PROPN
admet-648	38	57	baker	baker	PROPN
admet-648	38	58	,	,	PUNCT
admet-648	38	59	avantor	avantor	NOUN
admet-648	38	60	performance	performance	NOUN
admet-648	38	61	materials	material	NOUN
admet-648	38	62	,	,	PUNCT
admet-648	38	63	pa	pa	PROPN
admet-648	38	64	,	,	PUNCT
admet-648	38	65	usa	usa	PROPN
admet-648	38	66	.	.	PROPN
admet-648	38	67	formic	formic	PROPN
admet-648	38	68	acid	acid	PROPN
admet-648	38	69	was	be	AUX
admet-648	38	70	purchased	purchase	VERB
admet-648	38	71	from	from	ADP
admet-648	38	72	avra	avra	ADJ
admet-648	38	73	synthesis	synthesis	NOUN
admet-648	38	74	pvt	pvt	PROPN
admet-648	38	75	.	.	PROPN
admet-648	38	76	ltd	ltd	PROPN
admet-648	38	77	,	,	PUNCT
admet-648	38	78	hyderabad	hyderabad	PROPN
admet-648	38	79	,	,	PUNCT
admet-648	38	80	india	india	PROPN
admet-648	38	81	.	.	PUNCT
admet-648	39	1	the	the	DET
admet-648	39	2	control	control	NOUN
admet-648	39	3	balb	balb	VERB
admet-648	39	4	/	/	SYM
admet-648	39	5	c	c	NOUN
admet-648	39	6	mice	mouse	NOUN
admet-648	39	7	k2.edta	k2.edta	VERB
admet-648	39	8	plasma	plasma	NOUN
admet-648	39	9	sample	sample	NOUN
admet-648	39	10	was	be	AUX
admet-648	39	11	procured	procure	VERB
admet-648	39	12	from	from	ADP
admet-648	39	13	animal	animal	NOUN
admet-648	39	14	house	house	NOUN
admet-648	39	15	,	,	PUNCT
admet-648	39	16	jubilant	jubilant	ADJ
admet-648	39	17	biosys	biosys	NOUN
admet-648	39	18	.	.	PUNCT
admet-648	40	1	instrumentation	instrumentation	NOUN
admet-648	40	2	and	and	CCONJ
admet-648	40	3	chromatographic	chromatographic	ADJ
admet-648	40	4	conditions	condition	NOUN
admet-648	40	5	a	a	DET
admet-648	40	6	shimadzu	shimadzu	ADJ
admet-648	40	7	hplc	hplc	NOUN
admet-648	40	8	prominence	prominence	NOUN
admet-648	40	9	(	(	PUNCT
admet-648	40	10	shimadzu	shimadzu	PROPN
admet-648	40	11	,	,	PUNCT
admet-648	40	12	japan	japan	PROPN
admet-648	40	13	)	)	PUNCT
admet-648	40	14	coupled	couple	VERB
admet-648	40	15	with	with	ADP
admet-648	40	16	sciex	sciex	NOUN
admet-648	40	17	6500	6500	NUM
admet-648	40	18	triple	triple	ADJ
admet-648	40	19	quadrupole	quadrupole	NOUN
admet-648	40	20	(	(	PUNCT
admet-648	40	21	sciex	sciex	NOUN
admet-648	40	22	,	,	PUNCT
admet-648	40	23	redwood	redwood	NOUN
admet-648	40	24	city	city	NOUN
admet-648	40	25	,	,	PUNCT
admet-648	40	26	ca	ca	PROPN
admet-648	40	27	,	,	PUNCT
admet-648	40	28	usa	usa	PROPN
admet-648	40	29	)	)	PUNCT
admet-648	40	30	mass	mass	PROPN
admet-648	40	31	spectrometer	spectrometer	NOUN
admet-648	40	32	was	be	AUX
admet-648	40	33	used	use	VERB
admet-648	40	34	for	for	ADP
admet-648	40	35	all	all	DET
admet-648	40	36	analyses	analysis	NOUN
admet-648	40	37	.	.	PUNCT
admet-648	41	1	the	the	DET
admet-648	41	2	instrument	instrument	NOUN
admet-648	41	3	was	be	AUX
admet-648	41	4	controlled	control	VERB
admet-648	41	5	using	use	VERB
admet-648	41	6	analyst	analyst	NOUN
admet-648	41	7	software	software	NOUN
admet-648	41	8	(	(	PUNCT
admet-648	41	9	version	version	NOUN
admet-648	41	10	1.6.2	1.6.2	NUM
admet-648	41	11	)	)	PUNCT
admet-648	41	12	.	.	PUNCT
admet-648	42	1	ivosidenib	ivosidenib	NOUN
admet-648	42	2	and	and	CCONJ
admet-648	42	3	the	the	DET
admet-648	42	4	i.s	i.s	PROPN
admet-648	42	5	.	.	PROPN
admet-648	42	6	were	be	AUX
admet-648	42	7	eluted	elute	VERB
admet-648	42	8	using	use	VERB
admet-648	42	9	an	an	DET
admet-648	42	10	isocratic	isocratic	ADJ
admet-648	42	11	mobile	mobile	ADJ
admet-648	42	12	phase	phase	NOUN
admet-648	42	13	,	,	PUNCT
admet-648	42	14	which	which	PRON
admet-648	42	15	is	be	AUX
admet-648	42	16	a	a	DET
admet-648	42	17	mixture	mixture	NOUN
admet-648	42	18	of	of	ADP
admet-648	42	19	0.2	0.2	NUM
admet-648	42	20	%	%	NOUN
admet-648	42	21	formic	formic	ADJ
admet-648	42	22	acid	acid	NOUN
admet-648	42	23	in	in	ADP
admet-648	42	24	water	water	NOUN
admet-648	42	25	and	and	CCONJ
admet-648	42	26	acetonitrile	acetonitrile	NOUN
admet-648	42	27	(	(	PUNCT
admet-648	42	28	25:75	25:75	NUM
admet-648	42	29	,	,	PUNCT
admet-648	42	30	v	v	NOUN
admet-648	42	31	/	/	SYM
admet-648	42	32	v	v	NOUN
admet-648	42	33	)	)	PUNCT
admet-648	42	34	and	and	CCONJ
admet-648	42	35	chromatographed	chromatographe	VERB
admet-648	42	36	on	on	ADP
admet-648	42	37	an	an	DET
admet-648	42	38	atlantis	atlantis	PROPN
admet-648	42	39	dc18	dc18	PROPN
admet-648	42	40	column	column	NOUN
admet-648	42	41	(	(	PUNCT
admet-648	42	42	50	50	NUM
admet-648	42	43			NOUN
admet-648	42	44	4.6	4.6	NUM
admet-648	42	45	mm	mm	NOUN
admet-648	42	46	,	,	PUNCT
admet-648	42	47	3	3	NUM
admet-648	42	48	m	m	NOUN
admet-648	42	49	)	)	PUNCT
admet-648	42	50	maintained	maintain	VERB
admet-648	42	51	at	at	ADP
admet-648	42	52	40	40	NUM
admet-648	42	53	±	±	NUM
admet-648	42	54	1	1	NUM
admet-648	42	55	°	°	SYM
admet-648	42	56	c	c	NOUN
admet-648	42	57	.	.	PUNCT
admet-648	43	1	the	the	DET
admet-648	43	2	flowrate	flowrate	NOUN
admet-648	43	3	was	be	AUX
admet-648	43	4	1.0	1.0	NUM
admet-648	43	5	ml	ml	NOUN
admet-648	43	6	/	/	SYM
admet-648	43	7	min	min	NOUN
admet-648	43	8	.	.	PUNCT
admet-648	44	1	the	the	DET
admet-648	44	2	mass	mass	PROPN
admet-648	44	3	spectrometer	spectrometer	NOUN
admet-648	44	4	was	be	AUX
admet-648	44	5	operated	operate	VERB
admet-648	44	6	in	in	ADP
admet-648	44	7	the	the	DET
admet-648	44	8	multiple	multiple	ADJ
admet-648	44	9	reaction	reaction	NOUN
admet-648	44	10	mode	mode	NOUN
admet-648	44	11	(	(	PUNCT
admet-648	44	12	mrm	mrm	PROPN
admet-648	44	13	)	)	PUNCT
admet-648	44	14	with	with	ADP
admet-648	44	15	positive	positive	ADJ
admet-648	44	16	electrospray	electrospray	NOUN
admet-648	44	17	ionization	ionization	NOUN
admet-648	44	18	for	for	ADP
admet-648	44	19	the	the	DET
admet-648	44	20	quantitation	quantitation	NOUN
admet-648	44	21	of	of	ADP
admet-648	44	22	ivosidenib	ivosidenib	NOUN
admet-648	44	23	and	and	CCONJ
admet-648	45	1	the	the	DET
admet-648	45	2	i.s	i.s	PROPN
admet-648	45	3	.	.	PUNCT
admet-648	45	4	ionization	ionization	NOUN
admet-648	45	5	was	be	AUX
admet-648	45	6	conducted	conduct	VERB
admet-648	45	7	by	by	ADP
admet-648	45	8	applying	apply	VERB
admet-648	45	9	a	a	DET
admet-648	45	10	voltage	voltage	NOUN
admet-648	45	11	of	of	ADP
admet-648	45	12	5500	5500	NUM
admet-648	45	13	v	v	NOUN
admet-648	45	14	and	and	CCONJ
admet-648	45	15	source	source	NOUN
admet-648	45	16	temperature	temperature	NOUN
admet-648	45	17	was	be	AUX
admet-648	45	18	set	set	VERB
admet-648	45	19	at	at	ADP
admet-648	45	20	500	500	NUM
admet-648	45	21	°	°	NOUN
admet-648	45	22	c	c	NOUN
admet-648	45	23	.	.	PUNCT
admet-648	46	1	for	for	ADP
admet-648	46	2	analyte	analyte	NOUN
admet-648	46	3	and	and	CCONJ
admet-648	46	4	the	the	PRON
admet-648	46	5	is	be	AUX
admet-648	46	6	the	the	DET
admet-648	46	7	optimized	optimize	VERB
admet-648	46	8	source	source	NOUN
admet-648	46	9	parameters	parameter	NOUN
admet-648	46	10	viz	viz	PROPN
admet-648	46	11	.	.	PROPN
admet-648	46	12	,	,	PUNCT
admet-648	46	13	curtain	curtain	NOUN
admet-648	46	14	gas	gas	NOUN
admet-648	46	15	,	,	PUNCT
admet-648	46	16	gs1	gs1	NOUN
admet-648	46	17	,	,	PUNCT
admet-648	46	18	gs2	gs2	PROPN
admet-648	46	19	and	and	CCONJ
admet-648	46	20	cad	cad	PROPN
admet-648	46	21	were	be	AUX
admet-648	46	22	set	set	VERB
admet-648	46	23	at	at	ADP
admet-648	46	24	55	55	NUM
admet-648	46	25	,	,	PUNCT
admet-648	46	26	55	55	NUM
admet-648	46	27	,	,	PUNCT
admet-648	46	28	65	65	NUM
admet-648	46	29	and	and	CCONJ
admet-648	46	30	admet	admet	PROPN
admet-648	46	31	&	&	CCONJ
admet-648	46	32	dmpk	dmpk	PROPN
admet-648	46	33	7(2	7(2	NUM
admet-648	46	34	)	)	PUNCT
admet-648	46	35	(	(	PUNCT
admet-648	46	36	2018	2018	NUM
admet-648	46	37	)	)	PUNCT
admet-648	46	38	131	131	NUM
admet-648	46	39	-	-	SYM
admet-648	46	40	139	139	NUM
admet-648	46	41	quantitation	quantitation	NOUN
admet-648	46	42	of	of	ADP
admet-648	46	43	ivosidenib	ivosidenib	NOUN
admet-648	46	44	in	in	ADP
admet-648	46	45	mice	mice	NOUN
admet-648	46	46	plasma	plasma	NOUN
admet-648	46	47	by	by	ADP
admet-648	46	48	lc	lc	PROPN
admet-648	46	49	-	-	PUNCT
admet-648	46	50	esi	esi	PROPN
admet-648	46	51	-	-	PUNCT
admet-648	46	52	ms	ms	PROPN
admet-648	46	53	/	/	SYM
admet-648	46	54	ms	ms	NOUN
admet-648	46	55	doi	doi	PROPN
admet-648	46	56	:	:	PUNCT
admet-648	46	57	10.5599	10.5599	NUM
admet-648	46	58	/	/	SYM
admet-648	46	59	admet.648	admet.648	NOUN
admet-648	46	60	133	133	NUM
admet-648	46	61	10	10	NUM
admet-648	46	62	psi	psi	NOUN
admet-648	46	63	.	.	PUNCT
admet-648	47	1	the	the	DET
admet-648	47	2	compound	compound	NOUN
admet-648	47	3	parameters	parameter	NOUN
admet-648	47	4	viz	viz	PROPN
admet-648	47	5	.	.	PROPN
admet-648	47	6	,	,	PUNCT
admet-648	47	7	declustering	declustere	VERB
admet-648	47	8	potential	potential	ADJ
admet-648	47	9	(	(	PUNCT
admet-648	47	10	dp	dp	NOUN
admet-648	47	11	)	)	PUNCT
admet-648	47	12	,	,	PUNCT
admet-648	47	13	entrance	entrance	NOUN
admet-648	47	14	potential	potential	NOUN
admet-648	47	15	(	(	PUNCT
admet-648	47	16	ep	ep	PROPN
admet-648	47	17	)	)	PUNCT
admet-648	47	18	,	,	PUNCT
admet-648	47	19	collision	collision	NOUN
admet-648	47	20	energy	energy	NOUN
admet-648	47	21	(	(	PUNCT
admet-648	47	22	ce	ce	PROPN
admet-648	47	23	)	)	PUNCT
admet-648	47	24	and	and	CCONJ
admet-648	47	25	collision	collision	NOUN
admet-648	47	26	cell	cell	NOUN
admet-648	47	27	exit	exit	NOUN
admet-648	47	28	potential	potential	NOUN
admet-648	47	29	(	(	PUNCT
admet-648	47	30	cxp	cxp	PROPN
admet-648	47	31	)	)	PUNCT
admet-648	47	32	78	78	NUM
admet-648	47	33	,	,	PUNCT
admet-648	47	34	10	10	NUM
admet-648	47	35	,	,	PUNCT
admet-648	47	36	36	36	NUM
admet-648	47	37	,	,	PUNCT
admet-648	47	38	and	and	CCONJ
admet-648	47	39	5	5	NUM
admet-648	47	40	v	v	NOUN
admet-648	47	41	for	for	ADP
admet-648	47	42	ivosidenib	ivosidenib	NOUN
admet-648	47	43	and	and	CCONJ
admet-648	47	44	61	61	NUM
admet-648	47	45	,	,	PUNCT
admet-648	47	46	10	10	NUM
admet-648	47	47	,	,	PUNCT
admet-648	47	48	20	20	NUM
admet-648	47	49	,	,	PUNCT
admet-648	47	50	and	and	CCONJ
admet-648	47	51	18	18	NUM
admet-648	47	52	v	v	NOUN
admet-648	47	53	for	for	ADP
admet-648	47	54	the	the	PRON
admet-648	47	55	is	be	AUX
admet-648	47	56	.	.	PUNCT
admet-648	48	1	the	the	DET
admet-648	48	2	mass	mass	PROPN
admet-648	48	3	transition	transition	PROPN
admet-648	48	4	m	m	PROPN
admet-648	48	5	/	/	SYM
admet-648	48	6	z	z	PROPN
admet-648	48	7	(	(	PUNCT
admet-648	48	8	precursor	precursor	NOUN
admet-648	48	9	ion	ion	NOUN
admet-648	48	10			NOUN
admet-648	48	11	product	product	NOUN
admet-648	48	12	ion	ion	NOUN
admet-648	48	13	)	)	PUNCT
admet-648	48	14	583.1186.1	583.1186.1	NUM
admet-648	48	15	and	and	CCONJ
admet-648	48	16	309.2251.3	309.2251.3	PROPN
admet-648	48	17	were	be	AUX
admet-648	48	18	monitored	monitor	VERB
admet-648	48	19	for	for	ADP
admet-648	48	20	ivosidenib	ivosidenib	NOUN
admet-648	48	21	and	and	CCONJ
admet-648	48	22	the	the	DET
admet-648	48	23	i.s	i.s	PROPN
admet-648	48	24	,	,	PUNCT
admet-648	48	25	respectively	respectively	ADV
admet-648	48	26	.	.	PUNCT
admet-648	49	1	quadrupole	quadrupole	PROPN
admet-648	49	2	q1	q1	PROPN
admet-648	49	3	and	and	CCONJ
admet-648	49	4	q3	q3	PROPN
admet-648	49	5	were	be	AUX
admet-648	49	6	set	set	VERB
admet-648	49	7	on	on	ADP
admet-648	49	8	unit	unit	NOUN
admet-648	49	9	resolution	resolution	NOUN
admet-648	49	10	.	.	PUNCT
admet-648	50	1	the	the	DET
admet-648	50	2	dwell	dwell	NOUN
admet-648	50	3	time	time	NOUN
admet-648	50	4	was	be	AUX
admet-648	50	5	100	100	NUM
admet-648	50	6	msec	msec	NOUN
admet-648	50	7	.	.	PUNCT
admet-648	51	1	preparation	preparation	NOUN
admet-648	51	2	of	of	ADP
admet-648	51	3	stock	stock	NOUN
admet-648	51	4	and	and	CCONJ
admet-648	51	5	standard	standard	ADJ
admet-648	51	6	solutions	solution	NOUN
admet-648	51	7	primary	primary	ADJ
admet-648	51	8	stock	stock	NOUN
admet-648	51	9	solutions	solution	NOUN
admet-648	51	10	of	of	ADP
admet-648	51	11	ivosidenib	ivosidenib	NOUN
admet-648	51	12	for	for	ADP
admet-648	51	13	preparation	preparation	NOUN
admet-648	51	14	of	of	ADP
admet-648	51	15	calibration	calibration	NOUN
admet-648	51	16	curve	curve	NOUN
admet-648	51	17	(	(	PUNCT
admet-648	51	18	cc	cc	NOUN
admet-648	51	19	)	)	PUNCT
admet-648	51	20	and	and	CCONJ
admet-648	51	21	quality	quality	NOUN
admet-648	51	22	control	control	NOUN
admet-648	51	23	(	(	PUNCT
admet-648	51	24	qc	qc	PROPN
admet-648	51	25	)	)	PUNCT
admet-648	51	26	samples	sample	NOUN
admet-648	51	27	were	be	AUX
admet-648	51	28	prepared	prepare	VERB
admet-648	51	29	from	from	ADP
admet-648	51	30	separate	separate	ADJ
admet-648	51	31	weighing	weighing	NOUN
admet-648	51	32	.	.	PUNCT
admet-648	52	1	the	the	DET
admet-648	52	2	primary	primary	ADJ
admet-648	52	3	stock	stock	NOUN
admet-648	52	4	solution	solution	NOUN
admet-648	52	5	of	of	ADP
admet-648	52	6	ivosidenib	ivosidenib	NOUN
admet-648	52	7	(	(	PUNCT
admet-648	52	8	1144	1144	NUM
admet-648	52	9	µg	µg	NOUN
admet-648	52	10	/	/	SYM
admet-648	52	11	ml	ml	NOUN
admet-648	52	12	)	)	PUNCT
admet-648	52	13	and	and	CCONJ
admet-648	52	14	the	the	DET
admet-648	52	15	i.s	i.s	PROPN
admet-648	52	16	.	.	PUNCT
admet-648	53	1	(	(	PUNCT
admet-648	53	2	1000	1000	NUM
admet-648	53	3	µg	µg	NOUN
admet-648	53	4	/	/	SYM
admet-648	53	5	ml	ml	NOUN
admet-648	53	6	)	)	PUNCT
admet-648	53	7	were	be	AUX
admet-648	53	8	made	make	VERB
admet-648	53	9	in	in	ADP
admet-648	53	10	methanol	methanol	NOUN
admet-648	53	11	:	:	PUNCT
admet-648	53	12	water	water	NOUN
admet-648	53	13	(	(	PUNCT
admet-648	53	14	80:20	80:20	NUM
admet-648	53	15	,	,	PUNCT
admet-648	53	16	v	v	NOUN
admet-648	53	17	/	/	SYM
admet-648	53	18	v	v	NOUN
admet-648	53	19	)	)	PUNCT
admet-648	53	20	and	and	CCONJ
admet-648	53	21	dmso	dmso	NOUN
admet-648	53	22	,	,	PUNCT
admet-648	53	23	respectively	respectively	ADV
admet-648	53	24	.	.	PUNCT
admet-648	54	1	the	the	DET
admet-648	54	2	primary	primary	ADJ
admet-648	54	3	stock	stock	NOUN
admet-648	54	4	solution	solution	NOUN
admet-648	54	5	of	of	ADP
admet-648	54	6	ivosidenib	ivosidenib	NOUN
admet-648	54	7	and	and	CCONJ
admet-648	54	8	the	the	DET
admet-648	54	9	i.s	i.s	PROPN
admet-648	54	10	.	.	PROPN
admet-648	54	11	were	be	AUX
admet-648	54	12	stored	store	VERB
admet-648	54	13	at	at	ADP
admet-648	54	14	-20	-20	NUM
admet-648	54	15	°	°	NOUN
admet-648	54	16	c	c	NOUN
admet-648	54	17	,	,	PUNCT
admet-648	54	18	which	which	PRON
admet-648	54	19	were	be	AUX
admet-648	54	20	found	find	VERB
admet-648	54	21	to	to	PART
admet-648	54	22	be	be	AUX
admet-648	54	23	stable	stable	ADJ
admet-648	54	24	for	for	ADP
admet-648	54	25	45	45	NUM
admet-648	54	26	days	day	NOUN
admet-648	54	27	.	.	PUNCT
admet-648	55	1	ivosidenib	ivosidenib	PROPN
admet-648	55	2	primary	primary	ADJ
admet-648	55	3	stock	stock	NOUN
admet-648	55	4	solution	solution	NOUN
admet-648	55	5	was	be	AUX
admet-648	55	6	successively	successively	ADV
admet-648	55	7	diluted	dilute	VERB
admet-648	55	8	in	in	ADP
admet-648	55	9	methanol	methanol	NOUN
admet-648	55	10	:	:	PUNCT
admet-648	55	11	water	water	NOUN
admet-648	55	12	(	(	PUNCT
admet-648	55	13	80:20	80:20	NUM
admet-648	55	14	,	,	PUNCT
admet-648	55	15	v	v	NOUN
admet-648	55	16	/	/	SYM
admet-648	55	17	v	v	NOUN
admet-648	55	18	)	)	PUNCT
admet-648	55	19	to	to	PART
admet-648	55	20	prepare	prepare	VERB
admet-648	55	21	secondary	secondary	ADJ
admet-648	55	22	stock	stock	NOUN
admet-648	55	23	and	and	CCONJ
admet-648	55	24	working	work	VERB
admet-648	55	25	stock	stock	NOUN
admet-648	55	26	solutions	solution	NOUN
admet-648	55	27	,	,	PUNCT
admet-648	55	28	which	which	PRON
admet-648	55	29	were	be	AUX
admet-648	55	30	used	use	VERB
admet-648	55	31	to	to	PART
admet-648	55	32	prepare	prepare	VERB
admet-648	55	33	ccs	ccs	PROPN
admet-648	55	34	and	and	CCONJ
admet-648	55	35	qcs	qcs	PROPN
admet-648	55	36	.	.	PROPN
admet-648	55	37	working	work	VERB
admet-648	55	38	stock	stock	NOUN
admet-648	55	39	solutions	solution	NOUN
admet-648	55	40	were	be	AUX
admet-648	55	41	stored	store	VERB
admet-648	55	42	approximately	approximately	ADV
admet-648	55	43	at	at	ADP
admet-648	55	44	4	4	NUM
admet-648	55	45	°	°	ADP
admet-648	55	46	c	c	NOUN
admet-648	55	47	for	for	ADP
admet-648	55	48	ten	ten	NUM
admet-648	55	49	days	day	NOUN
admet-648	55	50	.	.	PUNCT
admet-648	56	1	a	a	DET
admet-648	56	2	working	work	VERB
admet-648	56	3	stock	stock	NOUN
admet-648	56	4	of	of	ADP
admet-648	56	5	the	the	DET
admet-648	56	6	i.s	i.s	PROPN
admet-648	56	7	.	.	PROPN
admet-648	56	8	solution	solution	NOUN
admet-648	56	9	(	(	PUNCT
admet-648	56	10	100	100	NUM
admet-648	56	11	ng	ng	NOUN
admet-648	56	12	/	/	SYM
admet-648	56	13	ml	ml	PROPN
admet-648	56	14	)	)	PUNCT
admet-648	56	15	was	be	AUX
admet-648	56	16	prepared	prepare	VERB
admet-648	56	17	in	in	ADP
admet-648	56	18	methanol	methanol	NOUN
admet-648	56	19	.	.	PUNCT
admet-648	57	1	samples	sample	NOUN
admet-648	57	2	for	for	ADP
admet-648	57	3	the	the	DET
admet-648	57	4	determination	determination	NOUN
admet-648	57	5	of	of	ADP
admet-648	57	6	precision	precision	NOUN
admet-648	57	7	and	and	CCONJ
admet-648	57	8	accuracy	accuracy	NOUN
admet-648	57	9	were	be	AUX
admet-648	57	10	prepared	prepare	VERB
admet-648	57	11	by	by	ADP
admet-648	57	12	spiking	spike	VERB
admet-648	57	13	control	control	NOUN
admet-648	57	14	mice	mice	NOUN
admet-648	57	15	plasma	plasma	NOUN
admet-648	57	16	in	in	ADP
admet-648	57	17	bulk	bulk	NOUN
admet-648	57	18	with	with	ADP
admet-648	57	19	ivosidenib	ivosidenib	NOUN
admet-648	57	20	at	at	ADP
admet-648	57	21	appropriate	appropriate	ADJ
admet-648	57	22	concentrations	concentration	NOUN
admet-648	57	23	:	:	PUNCT
admet-648	57	24	1.10	1.10	NUM
admet-648	57	25	ng	ng	NOUN
admet-648	57	26	/	/	SYM
admet-648	57	27	ml	ml	PROPN
admet-648	57	28	(	(	PUNCT
admet-648	57	29	lower	low	ADJ
admet-648	57	30	limit	limit	NOUN
admet-648	57	31	of	of	ADP
admet-648	57	32	quantitation	quantitation	NOUN
admet-648	57	33	quality	quality	NOUN
admet-648	57	34	control	control	NOUN
admet-648	57	35	,	,	PUNCT
admet-648	57	36	lloq	lloq	PROPN
admet-648	57	37	qc	qc	PROPN
admet-648	57	38	)	)	PUNCT
admet-648	57	39	,	,	PUNCT
admet-648	57	40	3.29	3.29	NUM
admet-648	57	41	ng	ng	PROPN
admet-648	57	42	/	/	SYM
admet-648	57	43	ml	ml	PROPN
admet-648	57	44	(	(	PUNCT
admet-648	57	45	low	low	ADJ
admet-648	57	46	quality	quality	NOUN
admet-648	57	47	control	control	NOUN
admet-648	57	48	,	,	PUNCT
admet-648	57	49	lqc	lqc	PROPN
admet-648	57	50	)	)	PUNCT
admet-648	57	51	,	,	PUNCT
admet-648	57	52	1715	1715	NUM
admet-648	57	53	ng	ng	NOUN
admet-648	57	54	/	/	SYM
admet-648	57	55	ml	ml	PROPN
admet-648	57	56	(	(	PUNCT
admet-648	57	57	medium	medium	ADJ
admet-648	57	58	quality	quality	NOUN
admet-648	57	59	control	control	NOUN
admet-648	57	60	,	,	PUNCT
admet-648	57	61	mqc	mqc	PROPN
admet-648	57	62	)	)	PUNCT
admet-648	57	63	and	and	CCONJ
admet-648	57	64	2607	2607	NUM
admet-648	57	65	ng	ng	PROPN
admet-648	57	66	/	/	SYM
admet-648	57	67	ml	ml	PROPN
admet-648	57	68	(	(	PUNCT
admet-648	57	69	high	high	ADJ
admet-648	57	70	quality	quality	NOUN
admet-648	57	71	control	control	NOUN
admet-648	57	72	,	,	PUNCT
admet-648	57	73	hqc	hqc	PROPN
admet-648	57	74	)	)	PUNCT
admet-648	57	75	and	and	CCONJ
admet-648	57	76	were	be	AUX
admet-648	57	77	stored	store	VERB
admet-648	57	78	at	at	ADP
admet-648	57	79	-80	-80	SYM
admet-648	57	80	±	±	NUM
admet-648	57	81	10	10	NUM
admet-648	57	82	°	°	ADP
admet-648	57	83	c	c	NOUN
admet-648	57	84	until	until	ADP
admet-648	57	85	analysis	analysis	NOUN
admet-648	57	86	.	.	PUNCT
admet-648	58	1	sample	sample	NOUN
admet-648	58	2	preparation	preparation	NOUN
admet-648	58	3	to	to	ADP
admet-648	58	4	an	an	DET
admet-648	58	5	aliquot	aliquot	NOUN
admet-648	58	6	of	of	ADP
admet-648	58	7	10	10	NUM
admet-648	58	8	µl	µl	ADP
admet-648	58	9	plasma	plasma	NOUN
admet-648	58	10	,	,	PUNCT
admet-648	58	11	500	500	NUM
admet-648	58	12	µl	µl	NOUN
admet-648	58	13	of	of	ADP
admet-648	58	14	methanol	methanol	NOUN
admet-648	58	15	containing	contain	VERB
admet-648	58	16	100	100	NUM
admet-648	58	17	ng	ng	PROPN
admet-648	58	18	/	/	SYM
admet-648	58	19	ml	ml	X
admet-648	58	20	i.s	i.s	PROPN
admet-648	58	21	.	.	PROPN
admet-648	59	1	was	be	AUX
admet-648	59	2	added	add	VERB
admet-648	59	3	and	and	CCONJ
admet-648	59	4	vortex	vortex	NOUN
admet-648	59	5	mixed	mix	VERB
admet-648	59	6	for	for	ADP
admet-648	59	7	2	2	NUM
admet-648	59	8	min	min	NOUN
admet-648	59	9	.	.	PUNCT
admet-648	60	1	thereafter	thereafter	ADV
admet-648	60	2	the	the	DET
admet-648	60	3	contents	content	NOUN
admet-648	60	4	were	be	AUX
admet-648	60	5	centrifuged	centrifuge	VERB
admet-648	60	6	for	for	ADP
admet-648	60	7	5	5	NUM
admet-648	60	8	min	min	NOUN
admet-648	60	9	at	at	ADP
admet-648	60	10	14,000	14,000	NUM
admet-648	60	11	rpm	rpm	NOUN
admet-648	60	12	in	in	ADP
admet-648	60	13	a	a	DET
admet-648	60	14	refrigerated	refrigerate	VERB
admet-648	60	15	centrifuge	centrifuge	NOUN
admet-648	60	16	(	(	PUNCT
admet-648	60	17	eppendorf	eppendorf	PROPN
admet-648	60	18	5424r	5424r	NUM
admet-648	60	19	)	)	PUNCT
admet-648	60	20	maintained	maintain	VERB
admet-648	60	21	at	at	ADP
admet-648	60	22	5	5	NUM
admet-648	60	23	°	°	NOUN
admet-648	60	24	c	c	NOUN
admet-648	60	25	.	.	PUNCT
admet-648	61	1	clear	clear	ADJ
admet-648	61	2	supernatant	supernatant	NOUN
admet-648	61	3	(	(	PUNCT
admet-648	61	4	200	200	NUM
admet-648	61	5	µl	µl	NOUN
admet-648	61	6	)	)	PUNCT
admet-648	61	7	was	be	AUX
admet-648	61	8	transferred	transfer	VERB
admet-648	61	9	into	into	ADP
admet-648	61	10	vials	vial	NOUN
admet-648	61	11	and	and	CCONJ
admet-648	61	12	2.0	2.0	NUM
admet-648	61	13	µl	µl	NOUN
admet-648	61	14	was	be	AUX
admet-648	61	15	injected	inject	VERB
admet-648	61	16	onto	onto	ADP
admet-648	61	17	lc	lc	NOUN
admet-648	61	18	-	-	PUNCT
admet-648	61	19	ms	ms	PROPN
admet-648	61	20	/	/	SYM
admet-648	61	21	ms	ms	NOUN
admet-648	61	22	system	system	NOUN
admet-648	61	23	for	for	ADP
admet-648	61	24	analysis	analysis	NOUN
admet-648	61	25	.	.	PUNCT
admet-648	62	1	validation	validation	NOUN
admet-648	62	2	procedures	procedure	NOUN
admet-648	62	3	the	the	DET
admet-648	62	4	validation	validation	NOUN
admet-648	62	5	experiments	experiment	NOUN
admet-648	62	6	were	be	AUX
admet-648	62	7	performed	perform	VERB
admet-648	62	8	in	in	ADP
admet-648	62	9	accordance	accordance	NOUN
admet-648	62	10	with	with	ADP
admet-648	62	11	the	the	DET
admet-648	62	12	us	us	PROPN
admet-648	62	13	food	food	NOUN
admet-648	62	14	and	and	CCONJ
admet-648	62	15	drug	drug	PROPN
admet-648	62	16	administration	administration	PROPN
admet-648	62	17	guideline	guideline	NOUN
admet-648	63	1	[	[	X
admet-648	63	2	6	6	NUM
admet-648	63	3	]	]	PUNCT
admet-648	63	4	.	.	PUNCT
admet-648	64	1	the	the	DET
admet-648	64	2	selectivity	selectivity	NOUN
admet-648	64	3	of	of	ADP
admet-648	64	4	the	the	DET
admet-648	64	5	method	method	NOUN
admet-648	64	6	was	be	AUX
admet-648	64	7	determined	determine	VERB
admet-648	64	8	by	by	ADP
admet-648	64	9	the	the	DET
admet-648	64	10	presence	presence	NOUN
admet-648	64	11	of	of	ADP
admet-648	64	12	interfering	interfere	VERB
admet-648	64	13	peaks	peak	NOUN
admet-648	64	14	from	from	ADP
admet-648	64	15	six	six	NUM
admet-648	64	16	individual	individual	ADJ
admet-648	64	17	drug	drug	NOUN
admet-648	64	18	-	-	PUNCT
admet-648	64	19	free	free	ADJ
admet-648	64	20	mice	mice	NOUN
admet-648	64	21	plasma	plasma	NOUN
admet-648	64	22	samples	sample	NOUN
admet-648	64	23	at	at	ADP
admet-648	64	24	the	the	DET
admet-648	64	25	retention	retention	NOUN
admet-648	64	26	times	time	NOUN
admet-648	64	27	of	of	ADP
admet-648	64	28	ivosidenib	ivosidenib	NOUN
admet-648	64	29	and	and	CCONJ
admet-648	64	30	the	the	DET
admet-648	64	31	i.s	i.s	PROPN
admet-648	64	32	.	.	PUNCT
admet-648	65	1	the	the	DET
admet-648	65	2	autoinjector	autoinjector	NOUN
admet-648	65	3	carryover	carryover	NOUN
admet-648	65	4	was	be	AUX
admet-648	65	5	determined	determine	VERB
admet-648	65	6	by	by	ADP
admet-648	65	7	injecting	inject	VERB
admet-648	65	8	the	the	DET
admet-648	65	9	highest	high	ADJ
admet-648	65	10	calibration	calibration	NOUN
admet-648	65	11	standard	standard	NOUN
admet-648	65	12	,	,	PUNCT
admet-648	65	13	followed	follow	VERB
admet-648	65	14	by	by	ADP
admet-648	65	15	injection	injection	NOUN
admet-648	65	16	of	of	ADP
admet-648	65	17	blank	blank	ADJ
admet-648	65	18	plasma	plasma	NOUN
admet-648	65	19	samples	sample	NOUN
admet-648	65	20	.	.	PUNCT
admet-648	66	1	the	the	DET
admet-648	66	2	lloq	lloq	NOUN
admet-648	66	3	was	be	AUX
admet-648	66	4	determined	determine	VERB
admet-648	66	5	as	as	ADP
admet-648	66	6	the	the	DET
admet-648	66	7	concentration	concentration	NOUN
admet-648	66	8	that	that	PRON
admet-648	66	9	has	have	VERB
admet-648	66	10	a	a	DET
admet-648	66	11	precision	precision	NOUN
admet-648	66	12	of	of	ADP
admet-648	66	13	<	<	X
admet-648	66	14	20	20	NUM
admet-648	66	15	%	%	NOUN
admet-648	66	16	of	of	ADP
admet-648	66	17	the	the	DET
admet-648	66	18	relative	relative	ADJ
admet-648	66	19	standard	standard	ADJ
admet-648	66	20	deviation	deviation	NOUN
admet-648	66	21	and	and	CCONJ
admet-648	66	22	accuracy	accuracy	NOUN
admet-648	66	23	between	between	ADP
admet-648	66	24	80	80	NUM
admet-648	66	25	-	-	SYM
admet-648	66	26	120	120	NUM
admet-648	66	27	%	%	NOUN
admet-648	66	28	of	of	ADP
admet-648	66	29	the	the	DET
admet-648	66	30	theoretical	theoretical	ADJ
admet-648	66	31	value	value	NOUN
admet-648	66	32	.	.	PUNCT
admet-648	67	1	the	the	DET
admet-648	67	2	response	response	NOUN
admet-648	67	3	of	of	ADP
admet-648	67	4	the	the	DET
admet-648	67	5	blanks	blank	NOUN
admet-648	67	6	was	be	AUX
admet-648	67	7	then	then	ADV
admet-648	67	8	compared	compare	VERB
admet-648	67	9	to	to	ADP
admet-648	67	10	that	that	PRON
admet-648	67	11	of	of	ADP
admet-648	67	12	the	the	DET
admet-648	67	13	lloq	lloq	NOUN
admet-648	67	14	.	.	PUNCT
admet-648	68	1	recovery	recovery	NOUN
admet-648	68	2	was	be	AUX
admet-648	68	3	determined	determine	VERB
admet-648	68	4	at	at	ADP
admet-648	68	5	lqc	lqc	NOUN
admet-648	68	6	and	and	CCONJ
admet-648	68	7	hqc	hqc	INTJ
admet-648	68	8	.	.	PUNCT
admet-648	69	1	recovery	recovery	NOUN
admet-648	69	2	for	for	ADP
admet-648	69	3	ivosidenib	ivosidenib	NOUN
admet-648	69	4	was	be	AUX
admet-648	69	5	calculated	calculate	VERB
admet-648	69	6	by	by	ADP
admet-648	69	7	comparing	compare	VERB
admet-648	69	8	the	the	DET
admet-648	69	9	mean	mean	ADJ
admet-648	69	10	peak	peak	NOUN
admet-648	69	11	response	response	NOUN
admet-648	69	12	of	of	ADP
admet-648	69	13	pre	pre	ADJ
admet-648	69	14	-	-	ADJ
admet-648	69	15	extraction	extraction	ADJ
admet-648	69	16	spiked	spiked	ADJ
admet-648	69	17	samples	sample	NOUN
admet-648	69	18	(	(	PUNCT
admet-648	69	19	spiked	spike	VERB
admet-648	69	20	before	before	ADP
admet-648	69	21	extraction	extraction	NOUN
admet-648	69	22	;	;	PUNCT
admet-648	69	23	n=6	n=6	NUM
admet-648	69	24	)	)	PUNCT
admet-648	69	25	to	to	ADP
admet-648	69	26	that	that	PRON
admet-648	69	27	of	of	ADP
admet-648	69	28	neat	neat	ADJ
admet-648	69	29	samples	sample	NOUN
admet-648	69	30	(	(	PUNCT
admet-648	69	31	n=6	n=6	NOUN
admet-648	69	32	)	)	PUNCT
admet-648	69	33	at	at	ADP
admet-648	69	34	each	each	DET
admet-648	69	35	qc	qc	PROPN
admet-648	69	36	level	level	NOUN
admet-648	69	37	.	.	PUNCT
admet-648	70	1	matrix	matrix	NOUN
admet-648	70	2	effect	effect	NOUN
admet-648	70	3	was	be	AUX
admet-648	70	4	assessed	assess	VERB
admet-648	70	5	by	by	ADP
admet-648	70	6	comparing	compare	VERB
admet-648	70	7	the	the	DET
admet-648	70	8	analyte	analyte	NOUN
admet-648	70	9	mean	mean	NOUN
admet-648	70	10	peak	peak	NOUN
admet-648	70	11	areas	area	NOUN
admet-648	70	12	at	at	ADP
admet-648	70	13	lqc	lqc	NOUN
admet-648	70	14	and	and	CCONJ
admet-648	70	15	hqc	hqc	INTJ
admet-648	70	16	concentration	concentration	NOUN
admet-648	70	17	after	after	ADP
admet-648	70	18	extraction	extraction	NOUN
admet-648	70	19	with	with	ADP
admet-648	70	20	the	the	DET
admet-648	70	21	mean	mean	ADJ
admet-648	70	22	peak	peak	NOUN
admet-648	70	23	areas	area	NOUN
admet-648	70	24	for	for	ADP
admet-648	70	25	post	post	NOUN
admet-648	70	26	extracted	extract	VERB
admet-648	70	27	blank	blank	ADJ
admet-648	70	28	plasma	plasma	NOUN
admet-648	70	29	samples	sample	NOUN
admet-648	70	30	spiked	spike	VERB
admet-648	70	31	with	with	ADP
admet-648	70	32	analyte	analyte	NOUN
admet-648	70	33	at	at	ADP
admet-648	70	34	equivalent	equivalent	ADJ
admet-648	70	35	concentrations	concentration	NOUN
admet-648	70	36	.	.	PUNCT
admet-648	71	1	recovery	recovery	NOUN
admet-648	71	2	and	and	CCONJ
admet-648	71	3	matrix	matrix	NOUN
admet-648	71	4	effect	effect	NOUN
admet-648	71	5	for	for	ADP
admet-648	71	6	the	the	DET
admet-648	71	7	i.s	i.s	PROPN
admet-648	71	8	.	.	PROPN
admet-648	71	9	was	be	AUX
admet-648	71	10	assessed	assess	VERB
admet-648	71	11	at	at	ADP
admet-648	71	12	single	single	ADJ
admet-648	71	13	concentration	concentration	NOUN
admet-648	71	14	(	(	PUNCT
admet-648	71	15	100	100	NUM
admet-648	71	16	ng	ng	NOUN
admet-648	71	17	/	/	SYM
admet-648	71	18	ml	ml	PROPN
admet-648	71	19	)	)	PUNCT
admet-648	71	20	.	.	PUNCT
admet-648	72	1	the	the	DET
admet-648	72	2	precision	precision	NOUN
admet-648	72	3	and	and	CCONJ
admet-648	72	4	accuracy	accuracy	NOUN
admet-648	72	5	of	of	ADP
admet-648	72	6	the	the	DET
admet-648	72	7	method	method	NOUN
admet-648	72	8	were	be	AUX
admet-648	72	9	evaluated	evaluate	VERB
admet-648	72	10	by	by	ADP
admet-648	72	11	measuring	measure	VERB
admet-648	72	12	the	the	DET
admet-648	72	13	four	four	NUM
admet-648	72	14	qc	qc	PROPN
admet-648	72	15	samples	samples	PROPN
admet-648	72	16	r.	r.	PROPN
admet-648	72	17	mullangi	mullangi	VERB
admet-648	72	18	et	et	PROPN
admet-648	72	19	al	al	PROPN
admet-648	72	20	.	.	PROPN
admet-648	72	21	admet	admet	PROPN
admet-648	72	22	&	&	CCONJ
admet-648	72	23	dmpk	dmpk	PROPN
admet-648	72	24	7(2	7(2	NUM
admet-648	72	25	)	)	PUNCT
admet-648	72	26	(	(	PUNCT
admet-648	72	27	2019	2019	NUM
admet-648	72	28	)	)	PUNCT
admet-648	72	29	131	131	NUM
admet-648	72	30	-	-	SYM
admet-648	72	31	139	139	NUM
admet-648	72	32	134	134	NUM
admet-648	72	33	(	(	PUNCT
admet-648	72	34	lloq	lloq	PROPN
admet-648	72	35	qc	qc	PROPN
admet-648	72	36	,	,	PUNCT
admet-648	72	37	lqc	lqc	PROPN
admet-648	72	38	,	,	PUNCT
admet-648	72	39	mqc	mqc	PROPN
admet-648	72	40	and	and	CCONJ
admet-648	72	41	hqc	hqc	PROPN
admet-648	72	42	)	)	PUNCT
admet-648	72	43	,	,	PUNCT
admet-648	72	44	which	which	PRON
admet-648	72	45	were	be	AUX
admet-648	72	46	prepared	prepare	VERB
admet-648	72	47	on	on	ADP
admet-648	72	48	each	each	DET
admet-648	72	49	validation	validation	NOUN
admet-648	72	50	day	day	NOUN
admet-648	72	51	(	(	PUNCT
admet-648	72	52	n=6	n=6	NOUN
admet-648	72	53	each	each	PRON
admet-648	72	54	)	)	PUNCT
admet-648	72	55	.	.	PUNCT
admet-648	73	1	inter	inter	ADJ
admet-648	73	2	-	-	ADJ
admet-648	73	3	day	day	ADJ
admet-648	73	4	precision	precision	NOUN
admet-648	73	5	was	be	AUX
admet-648	73	6	assessed	assess	VERB
admet-648	73	7	on	on	ADP
admet-648	73	8	four	four	NUM
admet-648	73	9	separate	separate	ADJ
admet-648	73	10	days	day	NOUN
admet-648	73	11	.	.	PUNCT
admet-648	74	1	interand	interand	VERB
admet-648	74	2	intra	intra	ADJ
admet-648	74	3	-	-	ADJ
admet-648	74	4	day	day	NOUN
admet-648	74	5	precisions	precision	NOUN
admet-648	74	6	were	be	AUX
admet-648	74	7	determined	determine	VERB
admet-648	74	8	by	by	ADP
admet-648	74	9	calculating	calculate	VERB
admet-648	74	10	percent	percent	NOUN
admet-648	74	11	relative	relative	ADJ
admet-648	74	12	standard	standard	ADJ
admet-648	74	13	deviation	deviation	NOUN
admet-648	74	14	(	(	PUNCT
admet-648	74	15	%	%	INTJ
admet-648	74	16	rsd	rsd	NOUN
admet-648	74	17	)	)	PUNCT
admet-648	74	18	that	that	PRON
admet-648	74	19	should	should	AUX
admet-648	74	20	be	be	AUX
admet-648	74	21	15	15	ADJ
admet-648	74	22	%	%	NOUN
admet-648	74	23	for	for	ADP
admet-648	74	24	all	all	DET
admet-648	74	25	qcs	qcs	PROPN
admet-648	74	26	except	except	SCONJ
admet-648	74	27	for	for	ADP
admet-648	74	28	lloq	lloq	PROPN
admet-648	74	29	qc	qc	PROPN
admet-648	74	30	where	where	SCONJ
admet-648	74	31	it	it	PRON
admet-648	74	32	should	should	AUX
admet-648	74	33	be	be	AUX
admet-648	74	34	20	20	NOUN
admet-648	74	35	%	%	NOUN
admet-648	74	36	.	.	PUNCT
admet-648	75	1	the	the	DET
admet-648	75	2	interand	interand	NOUN
admet-648	75	3	intra	intra	ADJ
admet-648	75	4	-	-	ADJ
admet-648	75	5	day	day	NOUN
admet-648	75	6	accuracy	accuracy	NOUN
admet-648	75	7	expressed	express	VERB
admet-648	75	8	as	as	ADP
admet-648	75	9	percent	percent	NOUN
admet-648	75	10	relative	relative	ADJ
admet-648	75	11	error	error	NOUN
admet-648	75	12	(	(	PUNCT
admet-648	75	13	%	%	INTJ
admet-648	75	14	re	re	VERB
admet-648	75	15	)	)	PUNCT
admet-648	75	16	was	be	AUX
admet-648	75	17	calculated	calculate	VERB
admet-648	75	18	by	by	ADP
admet-648	75	19	comparing	compare	VERB
admet-648	75	20	the	the	DET
admet-648	75	21	measured	measured	ADJ
admet-648	75	22	concentration	concentration	NOUN
admet-648	75	23	with	with	ADP
admet-648	75	24	the	the	DET
admet-648	75	25	nominal	nominal	ADJ
admet-648	75	26	value	value	NOUN
admet-648	75	27	and	and	CCONJ
admet-648	75	28	deviation	deviation	NOUN
admet-648	75	29	was	be	AUX
admet-648	75	30	limited	limit	VERB
admet-648	75	31	within	within	ADP
admet-648	75	32	±15	±15	NOUN
admet-648	75	33	%	%	NOUN
admet-648	75	34	except	except	SCONJ
admet-648	75	35	for	for	ADP
admet-648	75	36	lloq	lloq	PROPN
admet-648	75	37	qc	qc	PROPN
admet-648	75	38	where	where	SCONJ
admet-648	75	39	it	it	PRON
admet-648	75	40	should	should	AUX
admet-648	75	41	be	be	AUX
admet-648	75	42	20	20	NOUN
admet-648	75	43	%	%	NOUN
admet-648	75	44	.	.	PUNCT
admet-648	76	1	freeze	freeze	NOUN
admet-648	76	2	-	-	PUNCT
admet-648	76	3	thaw	thaw	NOUN
admet-648	76	4	stability	stability	NOUN
admet-648	76	5	following	follow	VERB
admet-648	76	6	three	three	NUM
admet-648	76	7	freeze	freeze	ADJ
admet-648	76	8	-	-	PUNCT
admet-648	76	9	thaw	thaw	NOUN
admet-648	76	10	cycles	cycle	NOUN
admet-648	76	11	was	be	AUX
admet-648	76	12	evaluated	evaluate	VERB
admet-648	76	13	(	(	PUNCT
admet-648	76	14	one	one	NUM
admet-648	76	15	day	day	NOUN
admet-648	76	16	duration	duration	NOUN
admet-648	76	17	between	between	ADP
admet-648	76	18	each	each	DET
admet-648	76	19	freeze	freeze	NOUN
admet-648	76	20	-	-	PUNCT
admet-648	76	21	thaw	thaw	NOUN
admet-648	76	22	cycle	cycle	NOUN
admet-648	76	23	and	and	CCONJ
admet-648	76	24	ivosidenib	ivosidenib	VERB
admet-648	76	25	spiked	spiked	ADJ
admet-648	76	26	plasma	plasma	NOUN
admet-648	76	27	samples	sample	NOUN
admet-648	76	28	were	be	AUX
admet-648	76	29	stored	store	VERB
admet-648	76	30	in	in	ADP
admet-648	76	31	-80	-80	PUNCT
admet-648	76	32	±	±	NUM
admet-648	76	33	10	10	NUM
admet-648	76	34	°	°	ADP
admet-648	76	35	c	c	NOUN
admet-648	76	36	between	between	ADP
admet-648	76	37	freeze	freeze	VERB
admet-648	76	38	/	/	SYM
admet-648	76	39	thaw	thaw	NOUN
admet-648	76	40	cycles	cycle	NOUN
admet-648	76	41	)	)	PUNCT
admet-648	76	42	.	.	PUNCT
admet-648	77	1	the	the	DET
admet-648	77	2	plasma	plasma	NOUN
admet-648	77	3	samples	sample	NOUN
admet-648	77	4	were	be	AUX
admet-648	77	5	thawed	thaw	VERB
admet-648	77	6	at	at	ADP
admet-648	77	7	room	room	NOUN
admet-648	77	8	temperature	temperature	NOUN
admet-648	77	9	for	for	ADP
admet-648	77	10	1	1	NUM
admet-648	77	11	h	h	NOUN
admet-648	77	12	and	and	CCONJ
admet-648	77	13	returned	return	VERB
admet-648	77	14	to	to	ADP
admet-648	77	15	the	the	DET
admet-648	77	16	freezer	freezer	NOUN
admet-648	77	17	.	.	PUNCT
admet-648	78	1	bench	bench	NOUN
admet-648	78	2	-	-	PUNCT
admet-648	78	3	top	top	NOUN
admet-648	78	4	stability	stability	NOUN
admet-648	78	5	was	be	AUX
admet-648	78	6	assessed	assess	VERB
admet-648	78	7	by	by	ADP
admet-648	78	8	analyzing	analyze	VERB
admet-648	78	9	samples	sample	NOUN
admet-648	78	10	that	that	PRON
admet-648	78	11	had	have	AUX
admet-648	78	12	been	be	AUX
admet-648	78	13	kept	keep	VERB
admet-648	78	14	at	at	ADP
admet-648	78	15	ambient	ambient	ADJ
admet-648	78	16	temperature	temperature	NOUN
admet-648	78	17	(	(	PUNCT
admet-648	78	18	25	25	NUM
admet-648	78	19	±	±	NUM
admet-648	78	20	1	1	NUM
admet-648	78	21	°	°	ADP
admet-648	78	22	c	c	NOUN
admet-648	78	23	)	)	PUNCT
admet-648	78	24	for	for	ADP
admet-648	78	25	6	6	NUM
admet-648	78	26	h.	h.	NOUN
admet-648	78	27	long	long	ADJ
admet-648	78	28	-	-	PUNCT
admet-648	78	29	term	term	NOUN
admet-648	78	30	stability	stability	NOUN
admet-648	78	31	was	be	AUX
admet-648	78	32	performed	perform	VERB
admet-648	78	33	by	by	ADP
admet-648	78	34	analyzing	analyze	VERB
admet-648	78	35	samples	sample	NOUN
admet-648	78	36	that	that	PRON
admet-648	78	37	had	have	AUX
admet-648	78	38	been	be	AUX
admet-648	78	39	stored	store	VERB
admet-648	78	40	at	at	ADP
admet-648	78	41	-80	-80	PUNCT
admet-648	78	42	±	±	NUM
admet-648	78	43	10	10	NUM
admet-648	78	44	°	°	ADP
admet-648	78	45	c	c	NOUN
admet-648	78	46	for	for	ADP
admet-648	78	47	30	30	NUM
admet-648	78	48	days	day	NOUN
admet-648	78	49	.	.	PUNCT
admet-648	79	1	the	the	DET
admet-648	79	2	stability	stability	NOUN
admet-648	79	3	of	of	ADP
admet-648	79	4	ivosidenib	ivosidenib	NOUN
admet-648	79	5	and	and	CCONJ
admet-648	79	6	the	the	DET
admet-648	79	7	i.s	i.s	PROPN
admet-648	79	8	.	.	PROPN
admet-648	80	1	in	in	ADP
admet-648	80	2	the	the	DET
admet-648	80	3	injection	injection	NOUN
admet-648	80	4	solvent	solvent	NOUN
admet-648	80	5	was	be	AUX
admet-648	80	6	determined	determine	VERB
admet-648	80	7	periodically	periodically	ADV
admet-648	80	8	by	by	ADP
admet-648	80	9	injecting	inject	VERB
admet-648	80	10	replicate	replicate	ADJ
admet-648	80	11	preparations	preparation	NOUN
admet-648	80	12	of	of	ADP
admet-648	80	13	processed	process	VERB
admet-648	80	14	plasma	plasma	NOUN
admet-648	80	15	samples	sample	NOUN
admet-648	80	16	for	for	ADP
admet-648	80	17	up	up	ADP
admet-648	80	18	to	to	PART
admet-648	80	19	24	24	NUM
admet-648	80	20	h	h	NOUN
admet-648	80	21	(	(	PUNCT
admet-648	80	22	in	in	ADP
admet-648	80	23	the	the	DET
admet-648	80	24	auto	auto	NOUN
admet-648	80	25	-	-	PUNCT
admet-648	80	26	sampler	sampler	NOUN
admet-648	80	27	at	at	ADP
admet-648	80	28	5	5	NUM
admet-648	80	29	°	°	NOUN
admet-648	80	30	c	c	NOUN
admet-648	80	31	)	)	PUNCT
admet-648	80	32	after	after	ADP
admet-648	80	33	the	the	DET
admet-648	80	34	initial	initial	ADJ
admet-648	80	35	injection	injection	NOUN
admet-648	80	36	.	.	PUNCT
admet-648	81	1	the	the	DET
admet-648	81	2	peak	peak	NOUN
admet-648	81	3	-	-	PUNCT
admet-648	81	4	areas	area	NOUN
admet-648	81	5	of	of	ADP
admet-648	81	6	the	the	DET
admet-648	81	7	analyte	analyte	NOUN
admet-648	81	8	and	and	CCONJ
admet-648	81	9	the	the	DET
admet-648	81	10	i.s	i.s	PROPN
admet-648	81	11	.	.	PROPN
admet-648	81	12	obtained	obtain	VERB
admet-648	81	13	at	at	ADP
admet-648	81	14	initial	initial	ADJ
admet-648	81	15	cycle	cycle	NOUN
admet-648	81	16	were	be	AUX
admet-648	81	17	used	use	VERB
admet-648	81	18	as	as	ADP
admet-648	81	19	the	the	DET
admet-648	81	20	reference	reference	NOUN
admet-648	81	21	to	to	PART
admet-648	81	22	determine	determine	VERB
admet-648	81	23	the	the	DET
admet-648	81	24	stability	stability	NOUN
admet-648	81	25	at	at	ADP
admet-648	81	26	subsequent	subsequent	ADJ
admet-648	81	27	points	point	NOUN
admet-648	81	28	.	.	PUNCT
admet-648	82	1	these	these	DET
admet-648	82	2	stability	stability	NOUN
admet-648	82	3	samples	sample	NOUN
admet-648	82	4	were	be	AUX
admet-648	82	5	processed	process	VERB
admet-648	82	6	and	and	CCONJ
admet-648	82	7	quantified	quantify	VERB
admet-648	82	8	against	against	ADP
admet-648	82	9	freshly	freshly	ADV
admet-648	82	10	spiked	spike	VERB
admet-648	82	11	calibration	calibration	NOUN
admet-648	82	12	curve	curve	NOUN
admet-648	82	13	standards	standard	NOUN
admet-648	82	14	along	along	ADP
admet-648	82	15	with	with	ADP
admet-648	82	16	freshly	freshly	ADV
admet-648	82	17	spiked	spiked	ADJ
admet-648	82	18	qc	qc	NOUN
admet-648	82	19	samples	sample	NOUN
admet-648	82	20	.	.	PUNCT
admet-648	83	1	samples	sample	NOUN
admet-648	83	2	were	be	AUX
admet-648	83	3	considered	consider	VERB
admet-648	83	4	to	to	PART
admet-648	83	5	be	be	AUX
admet-648	83	6	stable	stable	ADJ
admet-648	83	7	if	if	SCONJ
admet-648	83	8	assay	assay	NOUN
admet-648	83	9	values	value	NOUN
admet-648	83	10	were	be	AUX
admet-648	83	11	within	within	ADP
admet-648	83	12	the	the	DET
admet-648	83	13	acceptable	acceptable	ADJ
admet-648	83	14	limits	limit	NOUN
admet-648	83	15	of	of	ADP
admet-648	83	16	accuracy	accuracy	NOUN
admet-648	83	17	(	(	PUNCT
admet-648	83	18	±15	±15	NOUN
admet-648	83	19	%	%	NOUN
admet-648	83	20	re	re	NOUN
admet-648	83	21	)	)	PUNCT
admet-648	83	22	and	and	CCONJ
admet-648	83	23	precision	precision	NOUN
admet-648	83	24	(	(	PUNCT
admet-648	83	25	20	20	NOUN
admet-648	83	26	%	%	NOUN
admet-648	83	27	rsd	rsd	PROPN
admet-648	83	28	)	)	PUNCT
admet-648	83	29	.	.	PUNCT
admet-648	84	1	to	to	PART
admet-648	84	2	evaluate	evaluate	VERB
admet-648	84	3	the	the	DET
admet-648	84	4	effect	effect	NOUN
admet-648	84	5	of	of	ADP
admet-648	84	6	dilution	dilution	NOUN
admet-648	84	7	over	over	ADP
admet-648	84	8	the	the	DET
admet-648	84	9	calibration	calibration	NOUN
admet-648	84	10	range	range	NOUN
admet-648	84	11	,	,	PUNCT
admet-648	84	12	the	the	DET
admet-648	84	13	accuracy	accuracy	NOUN
admet-648	84	14	and	and	CCONJ
admet-648	84	15	precision	precision	NOUN
admet-648	84	16	of	of	ADP
admet-648	84	17	dilution	dilution	NOUN
admet-648	84	18	control	control	NOUN
admet-648	84	19	samples	sample	NOUN
admet-648	84	20	at	at	ADP
admet-648	84	21	9881	9881	NUM
admet-648	84	22	ng	ng	NOUN
admet-648	84	23	/	/	SYM
admet-648	84	24	ml	ml	PROPN
admet-648	84	25	(	(	PUNCT
admet-648	84	26	n=6	n=6	NOUN
admet-648	84	27	;	;	PUNCT
admet-648	84	28	3	3	NUM
admet-648	84	29	times	time	NOUN
admet-648	84	30	of	of	ADP
admet-648	84	31	the	the	DET
admet-648	84	32	uloq	uloq	NOUN
admet-648	84	33	)	)	PUNCT
admet-648	84	34	were	be	AUX
admet-648	84	35	assessed	assess	VERB
admet-648	84	36	by	by	ADP
admet-648	84	37	performing	perform	VERB
admet-648	84	38	a	a	DET
admet-648	84	39	5and	5and	NUM
admet-648	84	40	10fold	10fold	NUM
admet-648	84	41	dilution	dilution	NOUN
admet-648	84	42	.	.	PUNCT
admet-648	85	1	pharmacokinetic	pharmacokinetic	ADJ
admet-648	85	2	study	study	NOUN
admet-648	85	3	in	in	ADP
admet-648	85	4	mice	mouse	NOUN
admet-648	85	5	all	all	DET
admet-648	85	6	the	the	DET
admet-648	85	7	animal	animal	NOUN
admet-648	85	8	experiments	experiment	NOUN
admet-648	85	9	were	be	AUX
admet-648	85	10	approved	approve	VERB
admet-648	85	11	by	by	ADP
admet-648	85	12	institutional	institutional	ADJ
admet-648	85	13	animal	animal	NOUN
admet-648	85	14	ethical	ethical	PROPN
admet-648	85	15	committee	committee	NOUN
admet-648	85	16	(	(	PUNCT
admet-648	85	17	iaec	iaec	PROPN
admet-648	85	18	/	/	SYM
admet-648	85	19	jdc/2017/133	jdc/2017/133	NOUN
admet-648	85	20	)	)	PUNCT
admet-648	85	21	.	.	PUNCT
admet-648	86	1	male	male	ADJ
admet-648	86	2	balb	balb	NOUN
admet-648	86	3	/	/	SYM
admet-648	86	4	c	c	NOUN
admet-648	86	5	mice	mouse	NOUN
admet-648	86	6	(	(	PUNCT
admet-648	86	7	n=24	n=24	PROPN
admet-648	86	8	)	)	PUNCT
admet-648	86	9	were	be	AUX
admet-648	86	10	procured	procure	VERB
admet-648	86	11	from	from	ADP
admet-648	86	12	vivo	vivo	ADJ
admet-648	86	13	biotech	biotech	NOUN
admet-648	86	14	,	,	PUNCT
admet-648	86	15	hyderabad	hyderabad	PROPN
admet-648	86	16	,	,	PUNCT
admet-648	86	17	india	india	PROPN
admet-648	86	18	.	.	PUNCT
admet-648	87	1	the	the	DET
admet-648	87	2	animals	animal	NOUN
admet-648	87	3	were	be	AUX
admet-648	87	4	housed	house	VERB
admet-648	87	5	in	in	ADP
admet-648	87	6	jubilant	jubilant	ADJ
admet-648	87	7	biosys	biosys	NOUN
admet-648	87	8	animal	animal	PROPN
admet-648	87	9	house	house	NOUN
admet-648	87	10	facility	facility	NOUN
admet-648	87	11	in	in	ADP
admet-648	87	12	a	a	DET
admet-648	87	13	temperature	temperature	NOUN
admet-648	87	14	(	(	PUNCT
admet-648	87	15	22	22	NUM
admet-648	87	16	±	±	NUM
admet-648	87	17	2	2	NUM
admet-648	87	18	°	°	ADP
admet-648	87	19	c	c	NOUN
admet-648	87	20	)	)	PUNCT
admet-648	87	21	and	and	CCONJ
admet-648	87	22	humidity	humidity	NOUN
admet-648	87	23	(	(	PUNCT
admet-648	87	24	30	30	NUM
admet-648	87	25	-	-	SYM
admet-648	87	26	70	70	NUM
admet-648	87	27	%	%	NOUN
admet-648	87	28	)	)	PUNCT
admet-648	87	29	controlled	control	VERB
admet-648	87	30	room	room	NOUN
admet-648	87	31	(	(	PUNCT
admet-648	87	32	15	15	NUM
admet-648	87	33	air	air	NOUN
admet-648	87	34	changes	change	NOUN
admet-648	87	35	/	/	SYM
admet-648	87	36	hour	hour	NOUN
admet-648	87	37	)	)	PUNCT
admet-648	87	38	with	with	ADP
admet-648	87	39	a	a	DET
admet-648	87	40	12:12	12:12	NUM
admet-648	87	41	h	h	NOUN
admet-648	87	42	light	light	NOUN
admet-648	87	43	:	:	PUNCT
admet-648	87	44	dark	dark	ADJ
admet-648	87	45	cycles	cycle	NOUN
admet-648	87	46	,	,	PUNCT
admet-648	87	47	had	have	VERB
admet-648	87	48	free	free	ADJ
admet-648	87	49	access	access	NOUN
admet-648	87	50	to	to	ADP
admet-648	87	51	rodent	rodent	ADJ
admet-648	87	52	feed	feed	NOUN
admet-648	87	53	(	(	PUNCT
admet-648	87	54	altromin	altromin	NOUN
admet-648	87	55	spezialfutter	spezialfutter	PROPN
admet-648	87	56	gmbh	gmbh	PROPN
admet-648	87	57	&	&	CCONJ
admet-648	87	58	co.	co.	PROPN
admet-648	88	1	kg	kg	PROPN
admet-648	88	2	.	.	PROPN
admet-648	88	3	,	,	PUNCT
admet-648	89	1	i	i	PRON
admet-648	89	2	m	m	VERB
admet-648	89	3	seelenkamp	seelenkamp	ADJ
admet-648	89	4	20	20	NUM
admet-648	89	5	,	,	PUNCT
admet-648	89	6	d-32791	d-32791	PROPN
admet-648	89	7	,	,	PUNCT
admet-648	89	8	lage	lage	NOUN
admet-648	89	9	,	,	PUNCT
admet-648	89	10	germany	germany	PROPN
admet-648	89	11	)	)	PUNCT
admet-648	89	12	and	and	CCONJ
admet-648	89	13	water	water	NOUN
admet-648	89	14	for	for	ADP
admet-648	89	15	one	one	NUM
admet-648	89	16	week	week	NOUN
admet-648	89	17	before	before	ADP
admet-648	89	18	using	use	VERB
admet-648	89	19	for	for	ADP
admet-648	89	20	experimental	experimental	ADJ
admet-648	89	21	purpose	purpose	NOUN
admet-648	89	22	.	.	PUNCT
admet-648	90	1	following	follow	VERB
admet-648	90	2	4	4	NUM
admet-648	90	3	h	h	NOUN
admet-648	90	4	fast	fast	ADV
admet-648	90	5	(	(	PUNCT
admet-648	90	6	during	during	ADP
admet-648	90	7	the	the	DET
admet-648	90	8	fasting	fast	VERB
admet-648	90	9	period	period	NOUN
admet-648	90	10	animals	animal	NOUN
admet-648	90	11	had	have	VERB
admet-648	90	12	free	free	ADJ
admet-648	90	13	access	access	NOUN
admet-648	90	14	to	to	ADP
admet-648	90	15	water	water	NOUN
admet-648	90	16	)	)	PUNCT
admet-648	90	17	animals	animal	NOUN
admet-648	90	18	were	be	AUX
admet-648	90	19	divided	divide	VERB
admet-648	90	20	into	into	ADP
admet-648	90	21	two	two	NUM
admet-648	90	22	groups	group	NOUN
admet-648	90	23	(	(	PUNCT
admet-648	90	24	n=12	n=12	NOUN
admet-648	90	25	/	/	SYM
admet-648	90	26	group	group	NOUN
admet-648	90	27	)	)	PUNCT
admet-648	90	28	.	.	PUNCT
admet-648	91	1	group	group	NOUN
admet-648	91	2	i	i	PRON
admet-648	91	3	animals	animal	NOUN
admet-648	91	4	(	(	PUNCT
admet-648	91	5	26	26	NUM
admet-648	91	6	-	-	SYM
admet-648	91	7	30	30	NUM
admet-648	91	8	g	g	NOUN
admet-648	91	9	)	)	PUNCT
admet-648	91	10	received	receive	VERB
admet-648	91	11	ivosidenib	ivosidenib	NOUN
admet-648	91	12	orally	orally	ADV
admet-648	91	13	at	at	ADP
admet-648	91	14	5.0	5.0	NUM
admet-648	91	15	mg	mg	NOUN
admet-648	91	16	/	/	SYM
admet-648	91	17	kg	kg	PROPN
admet-648	91	18	(	(	PUNCT
admet-648	91	19	suspension	suspension	NOUN
admet-648	91	20	formulation	formulation	NOUN
admet-648	91	21	comprising	comprise	VERB
admet-648	91	22	0.5	0.5	NUM
admet-648	91	23	%	%	NOUN
admet-648	91	24	tween-80	tween-80	NUM
admet-648	91	25	and	and	CCONJ
admet-648	91	26	methyl	methyl	NOUN
admet-648	91	27	cellulose	cellulose	NOUN
admet-648	91	28	(	(	PUNCT
admet-648	91	29	0.5	0.5	NUM
admet-648	91	30	%	%	NOUN
admet-648	91	31	in	in	ADP
admet-648	91	32	water	water	NOUN
admet-648	91	33	)	)	PUNCT
admet-648	91	34	;	;	PUNCT
admet-648	91	35	strength	strength	NOUN
admet-648	91	36	:	:	PUNCT
admet-648	91	37	0.5	0.5	NUM
admet-648	91	38	mg	mg	NUM
admet-648	91	39	/	/	SYM
admet-648	91	40	ml	ml	PROPN
admet-648	91	41	;	;	PUNCT
admet-648	91	42	dose	dose	NOUN
admet-648	91	43	volume	volume	NOUN
admet-648	91	44	:	:	PUNCT
admet-648	91	45	10	10	NUM
admet-648	91	46	ml	ml	NOUN
admet-648	91	47	/	/	SYM
admet-648	91	48	kg	kg	NOUN
admet-648	91	49	)	)	PUNCT
admet-648	91	50	,	,	PUNCT
admet-648	91	51	whereas	whereas	SCONJ
admet-648	91	52	group	group	NOUN
admet-648	91	53	ii	ii	PROPN
admet-648	91	54	animals	animal	NOUN
admet-648	91	55	(	(	PUNCT
admet-648	91	56	27	27	NUM
admet-648	91	57	-	-	SYM
admet-648	91	58	31	31	NUM
admet-648	91	59	g	g	NOUN
admet-648	91	60	)	)	PUNCT
admet-648	91	61	received	receive	VERB
admet-648	91	62	ivosidenib	ivosidenib	NOUN
admet-648	91	63	intravenously	intravenously	ADV
admet-648	91	64	[	[	X
admet-648	91	65	5	5	NUM
admet-648	91	66	%	%	NOUN
admet-648	91	67	dmso	dmso	NOUN
admet-648	91	68	,	,	PUNCT
admet-648	91	69	5	5	NUM
admet-648	91	70	%	%	NOUN
admet-648	91	71	solutol	solutol	NOUN
admet-648	91	72	:	:	PUNCT
admet-648	91	73	absolute	absolute	ADJ
admet-648	91	74	alcohol	alcohol	NOUN
admet-648	91	75	(	(	PUNCT
admet-648	91	76	1:1	1:1	NUM
admet-648	91	77	,	,	PUNCT
admet-648	91	78	v	v	NOUN
admet-648	91	79	/	/	SYM
admet-648	91	80	v	v	NOUN
admet-648	91	81	)	)	PUNCT
admet-648	91	82	and	and	CCONJ
admet-648	91	83	90	90	NUM
admet-648	91	84	%	%	NOUN
admet-648	91	85	of	of	ADP
admet-648	91	86	normal	normal	ADJ
admet-648	91	87	saline	saline	NOUN
admet-648	91	88	;	;	PUNCT
admet-648	91	89	strength	strength	NOUN
admet-648	91	90	:	:	PUNCT
admet-648	91	91	0.2	0.2	NUM
admet-648	91	92	mg	mg	NUM
admet-648	91	93	/	/	SYM
admet-648	91	94	ml	ml	PROPN
admet-648	91	95	;	;	PUNCT
admet-648	91	96	dose	dose	NOUN
admet-648	91	97	volume	volume	NOUN
admet-648	91	98	:	:	PUNCT
admet-648	91	99	10	10	NUM
admet-648	91	100	ml	ml	NOUN
admet-648	91	101	/	/	SYM
admet-648	91	102	kg	kg	X
admet-648	91	103	]	]	X
admet-648	91	104	at	at	ADP
admet-648	91	105	2.0	2.0	NUM
admet-648	91	106	mg	mg	PROPN
admet-648	91	107	/	/	SYM
admet-648	91	108	kg	kg	PROPN
admet-648	91	109	dose	dose	PROPN
admet-648	91	110	.	.	PUNCT
admet-648	92	1	post	post	ADJ
admet-648	92	2	-	-	ADJ
admet-648	92	3	dosing	dosing	ADJ
admet-648	92	4	serial	serial	ADJ
admet-648	92	5	blood	blood	NOUN
admet-648	92	6	samples	sample	NOUN
admet-648	92	7	(	(	PUNCT
admet-648	92	8	40	40	NUM
admet-648	92	9	µl	µl	NOUN
admet-648	92	10	,	,	PUNCT
admet-648	92	11	sparse	sparse	ADJ
admet-648	92	12	sampling	sampling	NOUN
admet-648	92	13	was	be	AUX
admet-648	92	14	done	do	VERB
admet-648	92	15	and	and	CCONJ
admet-648	92	16	at	at	ADP
admet-648	92	17	each	each	DET
admet-648	92	18	time	time	NOUN
admet-648	92	19	point	point	NOUN
admet-648	92	20	three	three	NUM
admet-648	92	21	mice	mouse	NOUN
admet-648	92	22	were	be	AUX
admet-648	92	23	used	use	VERB
admet-648	92	24	for	for	ADP
admet-648	92	25	blood	blood	NOUN
admet-648	92	26	sampling	sampling	NOUN
admet-648	92	27	)	)	PUNCT
admet-648	92	28	were	be	AUX
admet-648	92	29	collected	collect	VERB
admet-648	92	30	using	use	VERB
admet-648	92	31	micropipettes	micropipette	NOUN
admet-648	92	32	(	(	PUNCT
admet-648	92	33	microcaps	microcap	NOUN
admet-648	92	34	®	®	NOUN
admet-648	92	35	;	;	PUNCT
admet-648	92	36	catalogue	catalogue	NOUN
admet-648	92	37	number	number	NOUN
admet-648	92	38	:	:	PUNCT
admet-648	92	39	1	1	NUM
admet-648	92	40	-	-	PUNCT
admet-648	92	41	000	000	NUM
admet-648	92	42	-	-	PUNCT
admet-648	92	43	0500	0500	NUM
admet-648	92	44	)	)	PUNCT
admet-648	92	45	through	through	ADP
admet-648	92	46	tail	tail	NOUN
admet-648	92	47	vein	vein	NOUN
admet-648	92	48	into	into	ADP
admet-648	92	49	polypropylene	polypropylene	NOUN
admet-648	92	50	tubes	tube	NOUN
admet-648	92	51	containing	contain	VERB
admet-648	92	52	k2edta	k2edta	PROPN
admet-648	92	53	solution	solution	NOUN
admet-648	92	54	as	as	ADP
admet-648	92	55	an	an	DET
admet-648	92	56	anti	anti	ADJ
admet-648	92	57	-	-	NOUN
admet-648	92	58	coagulant	coagulant	NOUN
admet-648	92	59	at	at	ADP
admet-648	92	60	0.25	0.25	NUM
admet-648	92	61	,	,	PUNCT
admet-648	92	62	0.5	0.5	NUM
admet-648	92	63	,	,	PUNCT
admet-648	92	64	1	1	NUM
admet-648	92	65	,	,	PUNCT
admet-648	92	66	2	2	NUM
admet-648	92	67	,	,	PUNCT
admet-648	92	68	4	4	NUM
admet-648	92	69	,	,	PUNCT
admet-648	92	70	8	8	NUM
admet-648	92	71	,	,	PUNCT
admet-648	92	72	10	10	NUM
admet-648	92	73	,	,	PUNCT
admet-648	92	74	12	12	NUM
admet-648	92	75	,	,	PUNCT
admet-648	92	76	24	24	NUM
admet-648	92	77	,	,	PUNCT
admet-648	92	78	30	30	NUM
admet-648	92	79	,	,	PUNCT
admet-648	92	80	36	36	NUM
admet-648	92	81	and	and	CCONJ
admet-648	92	82	48	48	NUM
admet-648	92	83	h	h	NOUN
admet-648	92	84	(	(	PUNCT
admet-648	92	85	for	for	ADP
admet-648	92	86	oral	oral	ADJ
admet-648	92	87	study	study	NOUN
admet-648	92	88	)	)	PUNCT
admet-648	92	89	and	and	CCONJ
admet-648	92	90	0.12	0.12	NUM
admet-648	92	91	,	,	PUNCT
admet-648	92	92	0.25	0.25	NUM
admet-648	92	93	,	,	PUNCT
admet-648	92	94	0.5	0.5	NUM
admet-648	92	95	,	,	PUNCT
admet-648	92	96	1	1	NUM
admet-648	92	97	,	,	PUNCT
admet-648	92	98	2	2	NUM
admet-648	92	99	,	,	PUNCT
admet-648	92	100	4	4	NUM
admet-648	92	101	,	,	PUNCT
admet-648	92	102	8	8	NUM
admet-648	92	103	,	,	PUNCT
admet-648	92	104	10	10	NUM
admet-648	92	105	,	,	PUNCT
admet-648	92	106	12	12	NUM
admet-648	92	107	,	,	PUNCT
admet-648	92	108	24	24	NUM
admet-648	92	109	and	and	CCONJ
admet-648	92	110	36	36	NUM
admet-648	92	111	h	h	NOUN
admet-648	92	112	(	(	PUNCT
admet-648	92	113	for	for	ADP
admet-648	92	114	intravenous	intravenous	ADJ
admet-648	92	115	study	study	NOUN
admet-648	92	116	)	)	PUNCT
admet-648	92	117	.	.	PUNCT
admet-648	93	1	plasma	plasma	NOUN
admet-648	93	2	was	be	AUX
admet-648	93	3	harvested	harvest	VERB
admet-648	93	4	by	by	ADP
admet-648	93	5	centrifuging	centrifuge	VERB
admet-648	93	6	the	the	DET
admet-648	93	7	blood	blood	NOUN
admet-648	93	8	using	use	VERB
admet-648	93	9	biofuge	biofuge	NOUN
admet-648	93	10	(	(	PUNCT
admet-648	93	11	hereaus	hereaus	PROPN
admet-648	93	12	,	,	PUNCT
admet-648	93	13	germany	germany	PROPN
admet-648	93	14	)	)	PUNCT
admet-648	93	15	at	at	ADP
admet-648	93	16	1760	1760	NUM
admet-648	93	17	g	g	NOUN
admet-648	93	18	for	for	ADP
admet-648	93	19	5	5	NUM
admet-648	93	20	min	min	NOUN
admet-648	93	21	and	and	CCONJ
admet-648	93	22	stored	store	VERB
admet-648	93	23	frozen	frozen	ADJ
admet-648	93	24	at	at	ADP
admet-648	93	25	-80	-80	SYM
admet-648	93	26	±	±	NUM
admet-648	93	27	10	10	NUM
admet-648	93	28	°	°	ADP
admet-648	93	29	c	c	NOUN
admet-648	93	30	until	until	ADP
admet-648	93	31	analysis	analysis	NOUN
admet-648	93	32	.	.	PUNCT
admet-648	94	1	animals	animal	NOUN
admet-648	94	2	were	be	AUX
admet-648	94	3	allowed	allow	VERB
admet-648	94	4	to	to	PART
admet-648	94	5	access	access	VERB
admet-648	94	6	feed	feed	NOUN
admet-648	94	7	2	2	NUM
admet-648	94	8	h	h	NOUN
admet-648	94	9	post	post	ADJ
admet-648	94	10	-	-	ADJ
admet-648	94	11	dosing	dosing	ADJ
admet-648	94	12	.	.	PUNCT
admet-648	95	1	admet	admet	PROPN
admet-648	95	2	&	&	CCONJ
admet-648	95	3	dmpk	dmpk	PROPN
admet-648	95	4	7(2	7(2	NUM
admet-648	95	5	)	)	PUNCT
admet-648	95	6	(	(	PUNCT
admet-648	95	7	2018	2018	NUM
admet-648	95	8	)	)	PUNCT
admet-648	95	9	131	131	NUM
admet-648	95	10	-	-	SYM
admet-648	95	11	139	139	NUM
admet-648	95	12	quantitation	quantitation	NOUN
admet-648	95	13	of	of	ADP
admet-648	95	14	ivosidenib	ivosidenib	NOUN
admet-648	95	15	in	in	ADP
admet-648	95	16	mice	mice	NOUN
admet-648	95	17	plasma	plasma	NOUN
admet-648	95	18	by	by	ADP
admet-648	95	19	lc	lc	PROPN
admet-648	95	20	-	-	PUNCT
admet-648	95	21	esi	esi	PROPN
admet-648	95	22	-	-	PUNCT
admet-648	95	23	ms	ms	PROPN
admet-648	95	24	/	/	SYM
admet-648	95	25	ms	ms	NOUN
admet-648	95	26	doi	doi	PROPN
admet-648	95	27	:	:	PUNCT
admet-648	95	28	10.5599	10.5599	NUM
admet-648	95	29	/	/	SYM
admet-648	95	30	admet.648	admet.648	NOUN
admet-648	95	31	135	135	NUM
admet-648	95	32	results	result	NOUN
admet-648	95	33	and	and	CCONJ
admet-648	95	34	discussion	discussion	NOUN
admet-648	95	35	liquid	liquid	ADJ
admet-648	95	36	chromatography	chromatography	NOUN
admet-648	95	37	and	and	CCONJ
admet-648	95	38	ms	ms	PROPN
admet-648	95	39	/	/	SYM
admet-648	95	40	ms	ms	PROPN
admet-648	95	41	conditions	condition	NOUN
admet-648	95	42	to	to	PART
admet-648	95	43	avoid	avoid	VERB
admet-648	95	44	the	the	DET
admet-648	95	45	potentially	potentially	ADV
admet-648	95	46	co	co	ADJ
admet-648	95	47	-	-	ADJ
admet-648	95	48	eluting	eluting	ADJ
admet-648	95	49	peaks	peak	NOUN
admet-648	95	50	from	from	ADP
admet-648	95	51	blank	blank	ADJ
admet-648	95	52	plasma	plasma	NOUN
admet-648	95	53	,	,	PUNCT
admet-648	95	54	which	which	PRON
admet-648	95	55	will	will	AUX
admet-648	95	56	influence	influence	VERB
admet-648	95	57	the	the	DET
admet-648	95	58	ionization	ionization	NOUN
admet-648	95	59	efficiency	efficiency	NOUN
admet-648	95	60	of	of	ADP
admet-648	95	61	ivosidenib	ivosidenib	NOUN
admet-648	95	62	and	and	CCONJ
admet-648	95	63	the	the	DET
admet-648	95	64	i.s	i.s	PROPN
admet-648	95	65	,	,	PUNCT
admet-648	95	66	the	the	DET
admet-648	95	67	mobile	mobile	ADJ
admet-648	95	68	phase	phase	NOUN
admet-648	95	69	was	be	AUX
admet-648	95	70	optimized	optimize	VERB
admet-648	95	71	along	along	ADP
admet-648	95	72	with	with	ADP
admet-648	95	73	chromatographic	chromatographic	ADJ
admet-648	95	74	conditions	condition	NOUN
admet-648	95	75	.	.	PUNCT
admet-648	96	1	in	in	ADP
admet-648	96	2	order	order	NOUN
admet-648	96	3	to	to	PART
admet-648	96	4	get	get	VERB
admet-648	96	5	chromatograms	chromatogram	NOUN
admet-648	96	6	with	with	ADP
admet-648	96	7	good	good	ADJ
admet-648	96	8	separation	separation	NOUN
admet-648	96	9	,	,	PUNCT
admet-648	96	10	peak	peak	NOUN
admet-648	96	11	shape	shape	NOUN
admet-648	96	12	and	and	CCONJ
admet-648	96	13	resolution	resolution	NOUN
admet-648	96	14	for	for	ADP
admet-648	96	15	ivosidenib	ivosidenib	NOUN
admet-648	96	16	and	and	CCONJ
admet-648	96	17	the	the	DET
admet-648	96	18	i.s	i.s	PROPN
admet-648	96	19	,	,	PUNCT
admet-648	96	20	feasibility	feasibility	NOUN
admet-648	96	21	of	of	ADP
admet-648	96	22	various	various	ADJ
admet-648	96	23	mixture(s	mixture(s	NOUN
admet-648	96	24	)	)	PUNCT
admet-648	96	25	of	of	ADP
admet-648	96	26	solvents	solvent	NOUN
admet-648	96	27	such	such	ADJ
admet-648	96	28	as	as	ADP
admet-648	96	29	acetonitrile	acetonitrile	NOUN
admet-648	96	30	and	and	CCONJ
admet-648	96	31	methanol	methanol	NOUN
admet-648	96	32	using	use	VERB
admet-648	96	33	different	different	ADJ
admet-648	96	34	buffers	buffer	NOUN
admet-648	96	35	such	such	ADJ
admet-648	96	36	as	as	ADP
admet-648	96	37	ammonium	ammonium	NOUN
admet-648	96	38	acetate	acetate	NOUN
admet-648	96	39	,	,	PUNCT
admet-648	96	40	ammonium	ammonium	NOUN
admet-648	96	41	formate	formate	NOUN
admet-648	96	42	and	and	CCONJ
admet-648	96	43	formic	formic	NOUN
admet-648	96	44	acid	acid	NOUN
admet-648	96	45	along	along	ADP
admet-648	96	46	with	with	ADP
admet-648	96	47	altered	altered	ADJ
admet-648	96	48	flow	flow	NOUN
admet-648	96	49	-	-	PUNCT
admet-648	96	50	rates	rate	NOUN
admet-648	96	51	(	(	PUNCT
admet-648	96	52	in	in	ADP
admet-648	96	53	the	the	DET
admet-648	96	54	range	range	NOUN
admet-648	96	55	of	of	ADP
admet-648	96	56	0.8	0.8	NUM
admet-648	96	57	-	-	SYM
admet-648	96	58	1.2	1.2	NUM
admet-648	96	59	ml	ml	NOUN
admet-648	96	60	/	/	SYM
admet-648	96	61	min	min	NOUN
admet-648	96	62	)	)	PUNCT
admet-648	96	63	were	be	AUX
admet-648	96	64	tested	test	VERB
admet-648	96	65	.	.	PUNCT
admet-648	97	1	the	the	DET
admet-648	97	2	resolution	resolution	NOUN
admet-648	97	3	of	of	ADP
admet-648	97	4	ivosidenib	ivosidenib	NOUN
admet-648	97	5	and	and	CCONJ
admet-648	97	6	the	the	DET
admet-648	97	7	i.s	i.s	PROPN
admet-648	97	8	.	.	PROPN
admet-648	97	9	was	be	AUX
admet-648	97	10	achieved	achieve	VERB
admet-648	97	11	with	with	ADP
admet-648	97	12	0.2	0.2	NUM
admet-648	97	13	%	%	NOUN
admet-648	97	14	formic	formic	ADJ
admet-648	97	15	acid	acid	NOUN
admet-648	97	16	:	:	PUNCT
admet-648	97	17	acetonitrile	acetonitrile	NOUN
admet-648	97	18	(	(	PUNCT
admet-648	97	19	25:75	25:75	NUM
admet-648	97	20	,	,	PUNCT
admet-648	97	21	v	v	NOUN
admet-648	97	22	/	/	SYM
admet-648	97	23	v	v	NOUN
admet-648	97	24	)	)	PUNCT
admet-648	97	25	at	at	ADP
admet-648	97	26	a	a	DET
admet-648	97	27	flow	flow	NOUN
admet-648	97	28	rate	rate	NOUN
admet-648	97	29	of	of	ADP
admet-648	97	30	1.0	1.0	NUM
admet-648	97	31	ml	ml	NOUN
admet-648	97	32	/	/	SYM
admet-648	97	33	min	min	PROPN
admet-648	97	34	.	.	PROPN
admet-648	97	35	atlantis	atlantis	PROPN
admet-648	97	36	dc18	dc18	PROPN
admet-648	97	37	column	column	NOUN
admet-648	97	38	(	(	PUNCT
admet-648	97	39	100	100	NUM
admet-648	97	40			NOUN
admet-648	97	41	4.6	4.6	NUM
admet-648	97	42	mm	mm	NOUN
admet-648	97	43	,	,	PUNCT
admet-648	97	44	3	3	NUM
admet-648	97	45	µm	µm	NOUN
admet-648	97	46	)	)	PUNCT
admet-648	97	47	was	be	AUX
admet-648	97	48	best	well	ADV
admet-648	97	49	suited	suit	VERB
admet-648	97	50	to	to	PART
admet-648	97	51	provide	provide	VERB
admet-648	97	52	the	the	DET
admet-648	97	53	symmetric	symmetric	ADJ
admet-648	97	54	peaks	peak	NOUN
admet-648	97	55	and	and	CCONJ
admet-648	97	56	baseline	baseline	NOUN
admet-648	97	57	separation	separation	NOUN
admet-648	97	58	of	of	ADP
admet-648	97	59	ivosidenib	ivosidenib	NOUN
admet-648	97	60	and	and	CCONJ
admet-648	97	61	the	the	DET
admet-648	97	62	i.s	i.s	PROPN
admet-648	97	63	.	.	PROPN
admet-648	98	1	with	with	ADP
admet-648	98	2	the	the	DET
admet-648	98	3	retention	retention	NOUN
admet-648	98	4	time	time	NOUN
admet-648	98	5	of	of	ADP
admet-648	98	6	0.96	0.96	NUM
admet-648	98	7	and	and	CCONJ
admet-648	98	8	1.02	1.02	NUM
admet-648	98	9	min	min	NOUN
admet-648	98	10	,	,	PUNCT
admet-648	98	11	respectively	respectively	ADV
admet-648	98	12	.	.	PUNCT
admet-648	99	1	the	the	DET
admet-648	99	2	total	total	ADJ
admet-648	99	3	chromatographic	chromatographic	ADJ
admet-648	99	4	run	run	NOUN
admet-648	99	5	time	time	NOUN
admet-648	99	6	was	be	AUX
admet-648	99	7	2.0	2.0	NUM
admet-648	99	8	min	min	NOUN
admet-648	99	9	.	.	PROPN
admet-648	99	10	to	to	PART
admet-648	99	11	obtain	obtain	VERB
admet-648	99	12	optimum	optimum	ADJ
admet-648	99	13	ionization	ionization	NOUN
admet-648	99	14	and	and	CCONJ
admet-648	99	15	sensitivity	sensitivity	NOUN
admet-648	99	16	100	100	NUM
admet-648	99	17	ng	ng	PROPN
admet-648	99	18	/	/	SYM
admet-648	99	19	ml	ml	X
admet-648	99	20	ivosidenib	ivosidenib	PROPN
admet-648	99	21	solution	solution	NOUN
admet-648	99	22	was	be	AUX
admet-648	99	23	directly	directly	ADV
admet-648	99	24	injected	inject	VERB
admet-648	99	25	into	into	ADP
admet-648	99	26	mass	mass	ADJ
admet-648	99	27	spectrometer	spectrometer	NOUN
admet-648	99	28	and	and	CCONJ
admet-648	99	29	electrospray	electrospray	VERB
admet-648	99	30	ionization	ionization	NOUN
admet-648	99	31	(	(	PUNCT
admet-648	99	32	esi	esi	NOUN
admet-648	99	33	)	)	PUNCT
admet-648	99	34	full	full	ADJ
admet-648	99	35	scans	scan	NOUN
admet-648	99	36	were	be	AUX
admet-648	99	37	carried	carry	VERB
admet-648	99	38	out	out	ADP
admet-648	99	39	both	both	CCONJ
admet-648	99	40	in	in	ADP
admet-648	99	41	positive	positive	ADJ
admet-648	99	42	and	and	CCONJ
admet-648	99	43	negative	negative	ADJ
admet-648	99	44	ion	ion	NOUN
admet-648	99	45	detection	detection	NOUN
admet-648	99	46	modes	mode	NOUN
admet-648	99	47	.	.	PUNCT
admet-648	100	1	positive	positive	ADJ
admet-648	100	2	esi	esi	PROPN
admet-648	100	3	mode	mode	NOUN
admet-648	100	4	was	be	AUX
admet-648	100	5	chosen	choose	VERB
admet-648	100	6	as	as	SCONJ
admet-648	100	7	it	it	PRON
admet-648	100	8	provided	provide	VERB
admet-648	100	9	good	good	ADJ
admet-648	100	10	intensity	intensity	NOUN
admet-648	100	11	signals	signal	NOUN
admet-648	100	12	and	and	CCONJ
admet-648	100	13	formed	form	VERB
admet-648	100	14	protonated	protonate	VERB
admet-648	100	15	[	[	X
admet-648	100	16	m+h	m+h	X
admet-648	100	17	]	]	X
admet-648	100	18	+	+	CCONJ
admet-648	100	19	at	at	ADP
admet-648	100	20	m	m	PROPN
admet-648	100	21	/	/	SYM
admet-648	100	22	z	z	PROPN
admet-648	100	23	583.1	583.1	NUM
admet-648	100	24	.	.	PUNCT
admet-648	101	1	this	this	DET
admet-648	101	2	precursor	precursor	NOUN
admet-648	101	3	ion	ion	NOUN
admet-648	101	4	(	(	PUNCT
admet-648	101	5	q1	q1	PROPN
admet-648	101	6	)	)	PUNCT
admet-648	101	7	was	be	AUX
admet-648	101	8	selected	select	VERB
admet-648	101	9	for	for	ADP
admet-648	101	10	fragmentation	fragmentation	NOUN
admet-648	101	11	in	in	ADP
admet-648	101	12	ms	ms	PROPN
admet-648	101	13	/	/	SYM
admet-648	101	14	ms	ms	PROPN
admet-648	101	15	mode	mode	NOUN
admet-648	101	16	to	to	PART
admet-648	101	17	obtain	obtain	VERB
admet-648	101	18	most	most	ADV
admet-648	101	19	intense	intense	ADJ
admet-648	101	20	and	and	CCONJ
admet-648	101	21	consistent	consistent	ADJ
admet-648	101	22	product	product	NOUN
admet-648	101	23	ion	ion	NOUN
admet-648	101	24	(	(	PUNCT
admet-648	101	25	q3	q3	NOUN
admet-648	101	26	:	:	PUNCT
admet-648	101	27	m	m	PROPN
admet-648	101	28	/	/	SYM
admet-648	101	29	z	z	PROPN
admet-648	101	30	186.1	186.1	NUM
admet-648	101	31	)	)	PUNCT
admet-648	101	32	by	by	ADP
admet-648	101	33	optimizing	optimize	VERB
admet-648	101	34	the	the	DET
admet-648	101	35	declustering	declustering	ADJ
admet-648	101	36	potential	potential	NOUN
admet-648	101	37	,	,	PUNCT
admet-648	101	38	collision	collision	NOUN
admet-648	101	39	energy	energy	NOUN
admet-648	101	40	and	and	CCONJ
admet-648	101	41	collision	collision	NOUN
admet-648	101	42	cell	cell	NOUN
admet-648	101	43	exit	exit	NOUN
admet-648	101	44	potential	potential	NOUN
admet-648	101	45	.	.	PUNCT
admet-648	102	1	subsequently	subsequently	ADV
admet-648	102	2	,	,	PUNCT
admet-648	102	3	various	various	ADJ
admet-648	102	4	gases	gas	NOUN
admet-648	102	5	like	like	ADP
admet-648	102	6	nebulizer	nebulizer	NOUN
admet-648	102	7	gas	gas	NOUN
admet-648	102	8	(	(	PUNCT
admet-648	102	9	gs1	gs1	NOUN
admet-648	102	10	)	)	PUNCT
admet-648	102	11	,	,	PUNCT
admet-648	102	12	auxiliary	auxiliary	ADJ
admet-648	102	13	gas	gas	NOUN
admet-648	102	14	(	(	PUNCT
admet-648	102	15	gs2	gs2	PROPN
admet-648	102	16	)	)	PUNCT
admet-648	102	17	,	,	PUNCT
admet-648	102	18	collision	collision	NOUN
admet-648	102	19	gas	gas	NOUN
admet-648	102	20	and	and	CCONJ
admet-648	102	21	source	source	NOUN
admet-648	102	22	temperature	temperature	NOUN
admet-648	102	23	were	be	AUX
admet-648	102	24	optimized	optimize	VERB
admet-648	102	25	to	to	PART
admet-648	102	26	obtain	obtain	VERB
admet-648	102	27	adequate	adequate	ADJ
admet-648	102	28	and	and	CCONJ
admet-648	102	29	reproducible	reproducible	ADJ
admet-648	102	30	response	response	NOUN
admet-648	102	31	.	.	PUNCT
admet-648	103	1	mrm	mrm	PROPN
admet-648	103	2	mode	mode	PROPN
admet-648	103	3	was	be	AUX
admet-648	103	4	used	use	VERB
admet-648	103	5	to	to	PART
admet-648	103	6	obtain	obtain	VERB
admet-648	103	7	better	well	ADJ
admet-648	103	8	selectivity	selectivity	NOUN
admet-648	103	9	,	,	PUNCT
admet-648	103	10	with	with	ADP
admet-648	103	11	dwell	dwell	NOUN
admet-648	103	12	time	time	NOUN
admet-648	103	13	of	of	ADP
admet-648	103	14	100	100	NUM
admet-648	103	15	ms	ms	NOUN
admet-648	103	16	for	for	ADP
admet-648	103	17	each	each	DET
admet-648	103	18	transition	transition	NOUN
admet-648	103	19	.	.	PUNCT
admet-648	104	1	fragment	fragment	ADJ
admet-648	104	2	ions	ion	NOUN
admet-648	104	3	at	at	ADP
admet-648	104	4	m	m	PROPN
admet-648	104	5	/	/	SYM
admet-648	104	6	z	z	PROPN
admet-648	104	7	476	476	NUM
admet-648	104	8	,	,	PUNCT
admet-648	104	9	214	214	NUM
admet-648	104	10	,	,	PUNCT
admet-648	104	11	186	186	NUM
admet-648	104	12	and	and	CCONJ
admet-648	104	13	158	158	NUM
admet-648	104	14	were	be	AUX
admet-648	104	15	produced	produce	VERB
admet-648	104	16	as	as	ADP
admet-648	104	17	prominent	prominent	ADJ
admet-648	104	18	product	product	NOUN
admet-648	104	19	ions	ion	NOUN
admet-648	104	20	for	for	ADP
admet-648	104	21	ivosidenib	ivosidenib	NOUN
admet-648	104	22	due	due	ADJ
admet-648	104	23	to	to	ADP
admet-648	104	24	sequential	sequential	ADJ
admet-648	104	25	loss	loss	NOUN
admet-648	104	26	of	of	ADP
admet-648	104	27	m	m	PROPN
admet-648	104	28	/	/	SYM
admet-648	104	29	z	z	PROPN
admet-648	104	30	107	107	NUM
admet-648	104	31	,	,	PUNCT
admet-648	104	32	262	262	NUM
admet-648	104	33	,	,	PUNCT
admet-648	104	34	28	28	NUM
admet-648	104	35	and	and	CCONJ
admet-648	104	36	28	28	NUM
admet-648	104	37	from	from	ADP
admet-648	104	38	ivosidenib	ivosidenib	NOUN
admet-648	104	39	.	.	PUNCT
admet-648	105	1	the	the	DET
admet-648	105	2	postulated	postulate	VERB
admet-648	105	3	fragmentation	fragmentation	NOUN
admet-648	105	4	pattern	pattern	NOUN
admet-648	105	5	of	of	ADP
admet-648	105	6	ivosidenib	ivosidenib	NOUN
admet-648	105	7	is	be	AUX
admet-648	105	8	shown	show	VERB
admet-648	105	9	in	in	ADP
admet-648	105	10	figure	figure	NOUN
admet-648	105	11	1	1	NUM
admet-648	105	12	.	.	PUNCT
admet-648	106	1	due	due	ADP
admet-648	106	2	to	to	ADP
admet-648	106	3	nonavailability	nonavailability	NOUN
admet-648	106	4	of	of	ADP
admet-648	106	5	deuterated	deuterate	VERB
admet-648	106	6	ivosidenib	ivosidenib	NOUN
admet-648	106	7	to	to	PART
admet-648	106	8	use	use	VERB
admet-648	106	9	it	it	PRON
admet-648	106	10	as	as	ADP
admet-648	106	11	an	an	DET
admet-648	106	12	i.s	i.s	PROPN
admet-648	106	13	,	,	PUNCT
admet-648	106	14	we	we	PRON
admet-648	106	15	have	have	AUX
admet-648	106	16	used	use	VERB
admet-648	106	17	warfarin	warfarin	NOUN
admet-648	106	18	as	as	ADP
admet-648	106	19	an	an	DET
admet-648	106	20	i.s	i.s	PROPN
admet-648	106	21	.	.	PROPN
admet-648	106	22	and	and	CCONJ
admet-648	106	23	found	find	VERB
admet-648	106	24	to	to	PART
admet-648	106	25	be	be	AUX
admet-648	106	26	the	the	DET
admet-648	106	27	best	good	ADJ
admet-648	106	28	for	for	ADP
admet-648	106	29	present	present	ADJ
admet-648	106	30	purpose	purpose	NOUN
admet-648	106	31	based	base	VERB
admet-648	106	32	on	on	ADP
admet-648	106	33	the	the	DET
admet-648	106	34	chromatographic	chromatographic	ADJ
admet-648	106	35	elution	elution	NOUN
admet-648	106	36	,	,	PUNCT
admet-648	106	37	ionization	ionization	NOUN
admet-648	106	38	and	and	CCONJ
admet-648	106	39	reproducible	reproducible	ADJ
admet-648	106	40	and	and	CCONJ
admet-648	106	41	good	good	ADJ
admet-648	106	42	extraction	extraction	NOUN
admet-648	106	43	efficiency	efficiency	NOUN
admet-648	106	44	.	.	PUNCT
admet-648	107	1	for	for	ADP
admet-648	107	2	quantitation	quantitation	NOUN
admet-648	107	3	purpose	purpose	NOUN
admet-648	107	4	m	m	PROPN
admet-648	107	5	/	/	SYM
admet-648	107	6	z	z	PROPN
admet-648	107	7	583.1	583.1	NUM
admet-648	107	8	precursor	precursor	NOUN
admet-648	107	9	ion	ion	NOUN
admet-648	107	10	to	to	ADP
admet-648	107	11	the	the	DET
admet-648	107	12	m	m	PROPN
admet-648	107	13	/	/	SYM
admet-648	107	14	z	z	PROPN
admet-648	107	15	186.1	186.1	NUM
admet-648	107	16	and	and	CCONJ
admet-648	107	17	m	m	PROPN
admet-648	107	18	/	/	SYM
admet-648	107	19	z	z	PROPN
admet-648	107	20	309.2	309.2	NUM
admet-648	107	21	precursor	precursor	NOUN
admet-648	107	22	ion	ion	NOUN
admet-648	107	23	to	to	ADP
admet-648	107	24	the	the	DET
admet-648	107	25	m	m	PROPN
admet-648	107	26	/	/	SYM
admet-648	107	27	z	z	PROPN
admet-648	107	28	251.3	251.3	NUM
admet-648	107	29	was	be	AUX
admet-648	107	30	used	use	VERB
admet-648	107	31	for	for	ADP
admet-648	107	32	ivosidenib	ivosidenib	NOUN
admet-648	107	33	and	and	CCONJ
admet-648	107	34	the	the	DET
admet-648	107	35	i.s	i.s	PROPN
admet-648	107	36	,	,	PUNCT
admet-648	107	37	respectively	respectively	ADV
admet-648	107	38	.	.	PUNCT
admet-648	108	1	figure	figure	NOUN
admet-648	108	2	1	1	NUM
admet-648	108	3	.	.	PUNCT
admet-648	108	4	fragmentation	fragmentation	NOUN
admet-648	108	5	pattern	pattern	NOUN
admet-648	108	6	of	of	ADP
admet-648	108	7	ivosidenib	ivosidenib	PROPN
admet-648	108	8	r.	r.	PROPN
admet-648	108	9	mullangi	mullangi	AUX
admet-648	108	10	et	et	PROPN
admet-648	108	11	al	al	PROPN
admet-648	108	12	.	.	PROPN
admet-648	108	13	admet	admet	PROPN
admet-648	108	14	&	&	CCONJ
admet-648	108	15	dmpk	dmpk	PROPN
admet-648	108	16	7(2	7(2	NUM
admet-648	108	17	)	)	PUNCT
admet-648	108	18	(	(	PUNCT
admet-648	108	19	2019	2019	NUM
admet-648	108	20	)	)	PUNCT
admet-648	108	21	131	131	NUM
admet-648	108	22	-	-	SYM
admet-648	108	23	139	139	NUM
admet-648	108	24	136	136	NUM
admet-648	108	25	validation	validation	NOUN
admet-648	108	26	results	result	VERB
admet-648	108	27	selectivity	selectivity	NOUN
admet-648	108	28	among	among	ADP
admet-648	108	29	the	the	DET
admet-648	108	30	tested	test	VERB
admet-648	108	31	drug	drug	NOUN
admet-648	108	32	-	-	PUNCT
admet-648	108	33	free	free	ADJ
admet-648	108	34	mice	mouse	NOUN
admet-648	108	35	blank	blank	ADJ
admet-648	108	36	plasma	plasma	NOUN
admet-648	108	37	samples	sample	NOUN
admet-648	108	38	no	no	DET
admet-648	108	39	sample	sample	NOUN
admet-648	108	40	shown	show	VERB
admet-648	108	41	any	any	DET
admet-648	108	42	interference	interference	NOUN
admet-648	108	43	at	at	ADP
admet-648	108	44	the	the	DET
admet-648	108	45	retention	retention	NOUN
admet-648	108	46	times	time	NOUN
admet-648	108	47	of	of	ADP
admet-648	108	48	the	the	DET
admet-648	108	49	ivosidenib	ivosidenib	NOUN
admet-648	108	50	and	and	CCONJ
admet-648	108	51	the	the	DET
admet-648	108	52	i.s	i.s	PROPN
admet-648	108	53	.	.	PROPN
admet-648	108	54	indicating	indicate	VERB
admet-648	108	55	that	that	SCONJ
admet-648	108	56	the	the	DET
admet-648	108	57	method	method	NOUN
admet-648	108	58	is	be	AUX
admet-648	108	59	selective	selective	ADJ
admet-648	108	60	(	(	PUNCT
admet-648	108	61	figure	figure	NOUN
admet-648	108	62	2	2	NUM
admet-648	108	63	)	)	PUNCT
admet-648	108	64	.	.	PUNCT
admet-648	109	1	(	(	PUNCT
admet-648	109	2	a	a	X
admet-648	109	3	)	)	PUNCT
admet-648	109	4	mice	mouse	NOUN
admet-648	109	5	blank	blank	ADJ
admet-648	109	6	plasma	plasma	NOUN
admet-648	109	7	(	(	PUNCT
admet-648	109	8	b	b	X
admet-648	109	9	)	)	PUNCT
admet-648	109	10	i.s	i.s	PROPN
admet-648	109	11	.	.	PUNCT
admet-648	110	1	(	(	PUNCT
admet-648	110	2	c	c	X
admet-648	110	3	)	)	PUNCT
admet-648	110	4	ivosidenib	ivosidenib	NOUN
admet-648	110	5	lloq	lloq	VERB
admet-648	110	6	(	(	PUNCT
admet-648	110	7	d	d	NOUN
admet-648	110	8	)	)	PUNCT
admet-648	110	9	0.25	0.25	NUM
admet-648	110	10	h	h	NOUN
admet-648	110	11	plasma	plasma	NOUN
admet-648	110	12	sample	sample	NOUN
admet-648	110	13	figure	figure	NOUN
admet-648	110	14	2	2	NUM
admet-648	110	15	.	.	PUNCT
admet-648	110	16	typical	typical	ADJ
admet-648	110	17	mrm	mrm	PROPN
admet-648	110	18	chromatograms	chromatogram	NOUN
admet-648	110	19	of	of	ADP
admet-648	110	20	(	(	PUNCT
admet-648	110	21	a	a	DET
admet-648	110	22	)	)	PUNCT
admet-648	110	23	mice	mouse	NOUN
admet-648	110	24	blank	blank	ADJ
admet-648	110	25	sample	sample	NOUN
admet-648	110	26	(	(	PUNCT
admet-648	110	27	b	b	NOUN
admet-648	110	28	)	)	PUNCT
admet-648	110	29	mice	mouse	NOUN
admet-648	110	30	blank	blank	ADJ
admet-648	110	31	plasma	plasma	NOUN
admet-648	110	32	spiked	spike	VERB
admet-648	110	33	with	with	ADP
admet-648	110	34	i.s	i.s	PROPN
admet-648	110	35	.	.	PUNCT
admet-648	111	1	(	(	PUNCT
admet-648	111	2	c	c	X
admet-648	111	3	)	)	PUNCT
admet-648	111	4	mice	mouse	NOUN
admet-648	111	5	blank	blank	ADJ
admet-648	111	6	plasma	plasma	NOUN
admet-648	111	7	spiked	spike	VERB
admet-648	111	8	with	with	ADP
admet-648	111	9	ivosidenib	ivosidenib	NOUN
admet-648	111	10	at	at	ADP
admet-648	111	11	lloq	lloq	NOUN
admet-648	111	12	(	(	PUNCT
admet-648	111	13	1.10	1.10	NUM
admet-648	111	14	ng	ng	NOUN
admet-648	111	15	/	/	SYM
admet-648	111	16	ml	ml	PROPN
admet-648	111	17	)	)	PUNCT
admet-648	111	18	and	and	CCONJ
admet-648	111	19	(	(	PUNCT
admet-648	111	20	d	d	X
admet-648	111	21	)	)	PUNCT
admet-648	112	1	0.25	0.25	NUM
admet-648	112	2	h	h	NOUN
admet-648	112	3	plasma	plasma	NOUN
admet-648	112	4	sample	sample	NOUN
admet-648	112	5	showing	show	VERB
admet-648	112	6	ivosidenib	ivosidenib	NOUN
admet-648	112	7	(	(	PUNCT
admet-648	112	8	1953	1953	NUM
admet-648	112	9	ng	ng	PROPN
admet-648	112	10	/	/	SYM
admet-648	112	11	ml	ml	NOUN
admet-648	112	12	)	)	PUNCT
admet-648	112	13	peak	peak	NOUN
admet-648	112	14	obtained	obtain	VERB
admet-648	112	15	following	follow	VERB
admet-648	112	16	5.0	5.0	NUM
admet-648	112	17	mg	mg	NOUN
admet-648	112	18	/	/	SYM
admet-648	112	19	kg	kg	PROPN
admet-648	112	20	oral	oral	ADJ
admet-648	112	21	dose	dose	NOUN
admet-648	112	22	of	of	ADP
admet-648	112	23	ivosidenib	ivosidenib	NOUN
admet-648	112	24	to	to	ADP
admet-648	112	25	mice	mouse	NOUN
admet-648	112	26	.	.	PUNCT
admet-648	113	1	sensitivity	sensitivity	NOUN
admet-648	113	2	and	and	CCONJ
admet-648	113	3	carry	carry	VERB
admet-648	113	4	over	over	ADP
admet-648	113	5	the	the	DET
admet-648	113	6	lowest	low	ADJ
admet-648	113	7	limit	limit	NOUN
admet-648	113	8	of	of	ADP
admet-648	113	9	reliable	reliable	ADJ
admet-648	113	10	quantification	quantification	NOUN
admet-648	113	11	for	for	ADP
admet-648	113	12	the	the	DET
admet-648	113	13	analyte	analyte	NOUN
admet-648	113	14	was	be	AUX
admet-648	113	15	set	set	VERB
admet-648	113	16	at	at	ADP
admet-648	113	17	the	the	DET
admet-648	113	18	concentration	concentration	NOUN
admet-648	113	19	of	of	ADP
admet-648	113	20	the	the	DET
admet-648	113	21	lloq	lloq	NOUN
admet-648	113	22	.	.	PUNCT
admet-648	114	1	the	the	DET
admet-648	114	2	precision	precision	NOUN
admet-648	114	3	and	and	CCONJ
admet-648	114	4	accuracy	accuracy	NOUN
admet-648	114	5	at	at	ADP
admet-648	114	6	lloq	lloq	PROPN
admet-648	114	7	concentration	concentration	NOUN
admet-648	114	8	were	be	AUX
admet-648	114	9	found	find	VERB
admet-648	114	10	to	to	PART
admet-648	114	11	be	be	AUX
admet-648	114	12	6.12	6.12	NUM
admet-648	114	13	and	and	CCONJ
admet-648	114	14	91.0	91.0	NUM
admet-648	114	15	%	%	NOUN
admet-648	114	16	for	for	ADP
admet-648	114	17	ivosidenib	ivosidenib	NOUN
admet-648	114	18	.	.	PUNCT
admet-648	115	1	there	there	PRON
admet-648	115	2	was	be	VERB
admet-648	115	3	no	no	DET
admet-648	115	4	carry	carry	NOUN
admet-648	115	5	-	-	PUNCT
admet-648	115	6	over	over	NOUN
admet-648	115	7	produced	produce	VERB
admet-648	115	8	by	by	ADP
admet-648	115	9	the	the	DET
admet-648	115	10	highest	high	ADJ
admet-648	115	11	calibration	calibration	NOUN
admet-648	115	12	sample	sample	NOUN
admet-648	115	13	on	on	ADP
admet-648	115	14	the	the	DET
admet-648	115	15	following	following	NOUN
admet-648	115	16	injected	inject	VERB
admet-648	115	17	blank	blank	ADJ
admet-648	115	18	plasma	plasma	NOUN
admet-648	115	19	extract	extract	NOUN
admet-648	115	20	sample	sample	NOUN
admet-648	115	21	.	.	PUNCT
admet-648	116	1	recovery	recovery	NOUN
admet-648	116	2	the	the	DET
admet-648	116	3	mean	mean	ADJ
admet-648	116	4	±	±	PROPN
admet-648	116	5	s.d	s.d	PROPN
admet-648	116	6	recovery	recovery	NOUN
admet-648	116	7	at	at	ADP
admet-648	116	8	lqc	lqc	NOUN
admet-648	116	9	and	and	CCONJ
admet-648	116	10	hqc	hqc	PROPN
admet-648	116	11	was	be	AUX
admet-648	116	12	found	find	VERB
admet-648	116	13	to	to	PART
admet-648	116	14	be	be	AUX
admet-648	116	15	66.5	66.5	NUM
admet-648	116	16	±	±	NUM
admet-648	116	17	8.97	8.97	NUM
admet-648	116	18	and	and	CCONJ
admet-648	116	19	76.1	76.1	NUM
admet-648	116	20	±	±	NUM
admet-648	116	21	1.43	1.43	NUM
admet-648	116	22	%	%	NOUN
admet-648	116	23	,	,	PUNCT
admet-648	116	24	respectively	respectively	ADV
admet-648	116	25	.	.	PUNCT
admet-648	117	1	the	the	DET
admet-648	117	2	recovery	recovery	NOUN
admet-648	117	3	of	of	ADP
admet-648	117	4	the	the	DET
admet-648	117	5	i.s	i.s	PROPN
admet-648	117	6	.	.	PROPN
admet-648	117	7	was	be	AUX
admet-648	117	8	100	100	NUM
admet-648	117	9	±	±	NUM
admet-648	117	10	8.99	8.99	NUM
admet-648	117	11	%	%	NOUN
admet-648	117	12	.	.	PUNCT
admet-648	118	1	matrix	matrix	NOUN
admet-648	118	2	effect	effect	NOUN
admet-648	118	3	six	six	NUM
admet-648	118	4	different	different	ADJ
admet-648	118	5	lots	lot	NOUN
admet-648	118	6	of	of	ADP
admet-648	118	7	plasma	plasma	NOUN
admet-648	118	8	samples	sample	NOUN
admet-648	118	9	,	,	PUNCT
admet-648	118	10	spiked	spike	VERB
admet-648	118	11	with	with	ADP
admet-648	118	12	analyte	analyte	NOUN
admet-648	118	13	concentration	concentration	NOUN
admet-648	118	14	levels	level	NOUN
admet-648	118	15	at	at	ADP
admet-648	118	16	lqc	lqc	ADV
admet-648	118	17	and	and	CCONJ
admet-648	118	18	hqc	hqc	PROPN
admet-648	118	19	levels	level	NOUN
admet-648	118	20	were	be	AUX
admet-648	118	21	analyzed	analyze	VERB
admet-648	118	22	.	.	PUNCT
admet-648	119	1	matrix	matrix	NOUN
admet-648	119	2	effect	effect	NOUN
admet-648	119	3	for	for	ADP
admet-648	119	4	ivosidenib	ivosidenib	NOUN
admet-648	119	5	at	at	ADP
admet-648	119	6	lqc	lqc	NOUN
admet-648	119	7	and	and	CCONJ
admet-648	119	8	hqc	hqc	PROPN
admet-648	119	9	was	be	AUX
admet-648	119	10	0.99	0.99	NUM
admet-648	119	11	±	±	NUM
admet-648	119	12	6.82	6.82	NUM
admet-648	119	13	and	and	CCONJ
admet-648	119	14	1.04	1.04	NUM
admet-648	119	15	±	±	NUM
admet-648	119	16	1.70	1.70	NUM
admet-648	119	17	%	%	NOUN
admet-648	119	18	,	,	PUNCT
admet-648	119	19	respectively	respectively	ADV
admet-648	119	20	.	.	PUNCT
admet-648	120	1	the	the	DET
admet-648	120	2	matrix	matrix	NOUN
admet-648	120	3	effect	effect	NOUN
admet-648	120	4	for	for	ADP
admet-648	120	5	the	the	DET
admet-648	120	6	i.s	i.s	PROPN
admet-648	120	7	.	.	PROPN
admet-648	120	8	was	be	AUX
admet-648	120	9	1.09	1.09	NUM
admet-648	120	10	±	±	NUM
admet-648	120	11	4.13	4.13	NUM
admet-648	120	12	%	%	NOUN
admet-648	120	13	.	.	PUNCT
admet-648	121	1	the	the	DET
admet-648	121	2	results	result	NOUN
admet-648	121	3	have	have	AUX
admet-648	121	4	shown	show	VERB
admet-648	121	5	that	that	SCONJ
admet-648	121	6	the	the	DET
admet-648	121	7	precision	precision	NOUN
admet-648	121	8	and	and	CCONJ
admet-648	121	9	accuracy	accuracy	NOUN
admet-648	121	10	for	for	ADP
admet-648	121	11	analyzed	analyze	VERB
admet-648	121	12	samples	sample	NOUN
admet-648	121	13	were	be	AUX
admet-648	121	14	within	within	ADP
admet-648	121	15	acceptance	acceptance	NOUN
admet-648	121	16	range	range	NOUN
admet-648	121	17	.	.	PUNCT
admet-648	122	1	overall	overall	ADV
admet-648	122	2	it	it	PRON
admet-648	122	3	was	be	AUX
admet-648	122	4	found	find	VERB
admet-648	122	5	that	that	SCONJ
admet-648	122	6	there	there	PRON
admet-648	122	7	is	be	VERB
admet-648	122	8	no	no	DET
admet-648	122	9	impact	impact	NOUN
admet-648	122	10	on	on	ADP
admet-648	122	11	the	the	DET
admet-648	122	12	ionization	ionization	NOUN
admet-648	122	13	of	of	ADP
admet-648	122	14	analyte	analyte	NOUN
admet-648	122	15	and	and	CCONJ
admet-648	123	1	the	the	DET
admet-648	123	2	i.s	i.s	PROPN
admet-648	123	3	.	.	PROPN
admet-648	123	4	calibration	calibration	NOUN
admet-648	123	5	curve	curve	VERB
admet-648	123	6	the	the	DET
admet-648	123	7	plasma	plasma	NOUN
admet-648	123	8	calibration	calibration	NOUN
admet-648	123	9	curve	curve	NOUN
admet-648	123	10	was	be	AUX
admet-648	123	11	constructed	construct	VERB
admet-648	123	12	using	use	VERB
admet-648	123	13	eight	eight	NUM
admet-648	123	14	calibration	calibration	NOUN
admet-648	123	15	standards	standard	NOUN
admet-648	123	16	(	(	PUNCT
admet-648	123	17	viz	viz	PROPN
admet-648	123	18	.	.	PROPN
admet-648	123	19	,	,	PUNCT
admet-648	123	20	1.10	1.10	NUM
admet-648	123	21	,	,	PUNCT
admet-648	123	22	2.20	2.20	NUM
admet-648	123	23	,	,	PUNCT
admet-648	123	24	21.9	21.9	NUM
admet-648	123	25	,	,	PUNCT
admet-648	123	26	109	109	NUM
admet-648	123	27	,	,	PUNCT
admet-648	123	28	548	548	NUM
admet-648	123	29	,	,	PUNCT
admet-648	123	30	1097	1097	NUM
admet-648	123	31	,	,	PUNCT
admet-648	123	32	2264	2264	NUM
admet-648	123	33	and	and	CCONJ
admet-648	123	34	3293	3293	NUM
admet-648	123	35	ng	ng	NOUN
admet-648	123	36	/	/	SYM
admet-648	123	37	ml	ml	NOUN
admet-648	123	38	)	)	PUNCT
admet-648	123	39	.	.	PUNCT
admet-648	124	1	under	under	ADP
admet-648	124	2	the	the	DET
admet-648	124	3	analytical	analytical	ADJ
admet-648	124	4	conditions	condition	NOUN
admet-648	124	5	used	use	VERB
admet-648	124	6	in	in	ADP
admet-648	124	7	the	the	DET
admet-648	124	8	present	present	ADJ
admet-648	124	9	study	study	NOUN
admet-648	124	10	,	,	PUNCT
admet-648	124	11	the	the	DET
admet-648	124	12	calibration	calibration	NOUN
admet-648	124	13	curves	curve	NOUN
admet-648	124	14	of	of	ADP
admet-648	124	15	ivosidenib	ivosidenib	NOUN
admet-648	124	16	were	be	AUX
admet-648	124	17	found	find	VERB
admet-648	124	18	to	to	PART
admet-648	124	19	be	be	AUX
admet-648	124	20	linear	linear	ADJ
admet-648	124	21	.	.	PUNCT
admet-648	125	1	calibration	calibration	NOUN
admet-648	125	2	curve	curve	NOUN
admet-648	125	3	was	be	AUX
admet-648	125	4	prepared	prepare	VERB
admet-648	125	5	by	by	ADP
admet-648	125	6	determining	determine	VERB
admet-648	125	7	the	the	DET
admet-648	125	8	best	good	ADJ
admet-648	125	9	fit	fit	NOUN
admet-648	125	10	of	of	ADP
admet-648	125	11	peak	peak	NOUN
admet-648	125	12	-	-	PUNCT
admet-648	125	13	area	area	NOUN
admet-648	125	14	ratios	ratio	NOUN
admet-648	125	15	(	(	PUNCT
admet-648	125	16	peak	peak	NOUN
admet-648	125	17	area	area	NOUN
admet-648	125	18	analyte	analyte	NOUN
admet-648	125	19	/	/	SYM
admet-648	125	20	peak	peak	NOUN
admet-648	125	21	area	area	NOUN
admet-648	125	22	is	be	AUX
admet-648	125	23	)	)	PUNCT
admet-648	125	24	versus	versus	ADP
admet-648	125	25	concentration	concentration	NOUN
admet-648	125	26	,	,	PUNCT
admet-648	125	27	and	and	CCONJ
admet-648	125	28	fitted	fit	VERB
admet-648	125	29	to	to	ADP
admet-648	125	30	the	the	DET
admet-648	125	31	y	y	PROPN
admet-648	125	32	=	=	SYM
admet-648	125	33	mx	mx	PROPN
admet-648	126	1	+	+	NOUN
admet-648	126	2	c	c	VERB
admet-648	126	3	using	use	VERB
admet-648	126	4	weighing	weighing	NOUN
admet-648	126	5	factor	factor	NOUN
admet-648	126	6	(	(	PUNCT
admet-648	126	7	1	1	NUM
admet-648	126	8	/	/	SYM
admet-648	126	9	x2	x2	NUM
admet-648	126	10	)	)	PUNCT
admet-648	126	11	.	.	PUNCT
admet-648	127	1	the	the	DET
admet-648	127	2	average	average	ADJ
admet-648	127	3	slope	slope	NOUN
admet-648	127	4	and	and	CCONJ
admet-648	127	5	intercept	intercept	NOUN
admet-648	127	6	values	value	NOUN
admet-648	127	7	were	be	AUX
admet-648	127	8	admet	admet	PROPN
admet-648	127	9	&	&	CCONJ
admet-648	127	10	dmpk	dmpk	PROPN
admet-648	127	11	7(2	7(2	NUM
admet-648	127	12	)	)	PUNCT
admet-648	127	13	(	(	PUNCT
admet-648	127	14	2018	2018	NUM
admet-648	127	15	)	)	PUNCT
admet-648	127	16	131	131	NUM
admet-648	127	17	-	-	SYM
admet-648	127	18	139	139	NUM
admet-648	127	19	quantitation	quantitation	NOUN
admet-648	127	20	of	of	ADP
admet-648	127	21	ivosidenib	ivosidenib	NOUN
admet-648	127	22	in	in	ADP
admet-648	127	23	mice	mice	NOUN
admet-648	127	24	plasma	plasma	NOUN
admet-648	127	25	by	by	ADP
admet-648	127	26	lc	lc	PROPN
admet-648	127	27	-	-	PUNCT
admet-648	127	28	esi	esi	PROPN
admet-648	127	29	-	-	PUNCT
admet-648	127	30	ms	ms	PROPN
admet-648	127	31	/	/	SYM
admet-648	127	32	ms	ms	NOUN
admet-648	127	33	doi	doi	PROPN
admet-648	127	34	:	:	PUNCT
admet-648	127	35	10.5599	10.5599	NUM
admet-648	127	36	/	/	SYM
admet-648	127	37	admet.648	admet.648	PROPN
admet-648	127	38	137	137	NUM
admet-648	127	39	found	find	VERB
admet-648	127	40	to	to	PART
admet-648	127	41	be	be	AUX
admet-648	127	42	0.001173	0.001173	NUM
admet-648	127	43	and	and	CCONJ
admet-648	127	44	0.00014	0.00014	NUM
admet-648	127	45	,	,	PUNCT
admet-648	127	46	respectively	respectively	ADV
admet-648	127	47	.	.	PUNCT
admet-648	128	1	the	the	DET
admet-648	128	2	average	average	ADJ
admet-648	128	3	regression	regression	NOUN
admet-648	128	4	(	(	PUNCT
admet-648	128	5	n=4	n=4	NOUN
admet-648	128	6	)	)	PUNCT
admet-648	128	7	was	be	AUX
admet-648	128	8	found	find	VERB
admet-648	128	9	to	to	PART
admet-648	128	10	be	be	AUX
admet-648	128	11	0.995	0.995	NOUN
admet-648	128	12	.	.	PUNCT
admet-648	129	1	the	the	DET
admet-648	129	2	lowest	low	ADJ
admet-648	129	3	concentration	concentration	NOUN
admet-648	129	4	with	with	ADP
admet-648	129	5	the	the	DET
admet-648	129	6	rsd	rsd	NOUN
admet-648	129	7	<	<	X
admet-648	129	8	20	20	NUM
admet-648	129	9	%	%	NOUN
admet-648	129	10	was	be	AUX
admet-648	129	11	taken	take	VERB
admet-648	129	12	as	as	ADP
admet-648	129	13	lloq	lloq	NOUN
admet-648	129	14	and	and	CCONJ
admet-648	129	15	was	be	AUX
admet-648	129	16	found	find	VERB
admet-648	129	17	to	to	PART
admet-648	129	18	be	be	AUX
admet-648	129	19	1.10	1.10	NUM
admet-648	129	20	ng	ng	NOUN
admet-648	129	21	/	/	SYM
admet-648	129	22	ml	ml	PROPN
admet-648	129	23	.	.	PUNCT
admet-648	130	1	the	the	DET
admet-648	130	2	%	%	NOUN
admet-648	130	3	accuracy	accuracy	NOUN
admet-648	130	4	observed	observe	VERB
admet-648	130	5	for	for	ADP
admet-648	130	6	the	the	DET
admet-648	130	7	mean	mean	NOUN
admet-648	130	8	of	of	ADP
admet-648	130	9	back	back	ADV
admet-648	130	10	-	-	PUNCT
admet-648	130	11	calculated	calculate	VERB
admet-648	130	12	concentrations	concentration	NOUN
admet-648	130	13	for	for	ADP
admet-648	130	14	four	four	NUM
admet-648	130	15	calibration	calibration	NOUN
admet-648	130	16	curves	curve	NOUN
admet-648	130	17	for	for	ADP
admet-648	130	18	ivosidenib	ivosidenib	NOUN
admet-648	130	19	was	be	AUX
admet-648	130	20	within	within	ADP
admet-648	130	21	90.8	90.8	NUM
admet-648	130	22	-	-	SYM
admet-648	130	23	110	110	NUM
admet-648	130	24	;	;	PUNCT
admet-648	130	25	while	while	SCONJ
admet-648	130	26	the	the	DET
admet-648	130	27	precision	precision	NOUN
admet-648	130	28	(	(	PUNCT
admet-648	130	29	%	%	INTJ
admet-648	130	30	rsd	rsd	NOUN
admet-648	130	31	)	)	PUNCT
admet-648	130	32	values	value	NOUN
admet-648	130	33	ranged	range	VERB
admet-648	130	34	from	from	ADP
admet-648	130	35	2.08	2.08	NUM
admet-648	130	36	-	-	SYM
admet-648	130	37	9.42	9.42	NUM
admet-648	130	38	.	.	PUNCT
admet-648	131	1	accuracy	accuracy	NOUN
admet-648	131	2	and	and	CCONJ
admet-648	131	3	precision	precision	NOUN
admet-648	131	4	a	a	DET
admet-648	131	5	summary	summary	NOUN
admet-648	131	6	of	of	ADP
admet-648	131	7	the	the	DET
admet-648	131	8	accuracy	accuracy	NOUN
admet-648	131	9	and	and	CCONJ
admet-648	131	10	precision	precision	NOUN
admet-648	131	11	data	datum	NOUN
admet-648	131	12	for	for	ADP
admet-648	131	13	intraand	intraand	NOUN
admet-648	131	14	inter	inter	NOUN
admet-648	131	15	-	-	NOUN
admet-648	131	16	day	day	NOUN
admet-648	131	17	is	be	AUX
admet-648	131	18	listed	list	VERB
admet-648	131	19	in	in	ADP
admet-648	131	20	table	table	NOUN
admet-648	131	21	1	1	NUM
admet-648	131	22	.	.	PUNCT
admet-648	132	1	the	the	DET
admet-648	132	2	assay	assay	ADJ
admet-648	132	3	values	value	NOUN
admet-648	132	4	on	on	ADP
admet-648	132	5	both	both	CCONJ
admet-648	132	6	the	the	DET
admet-648	132	7	occasions	occasion	NOUN
admet-648	132	8	(	(	PUNCT
admet-648	132	9	intraand	intraand	X
admet-648	132	10	inter	inter	NOUN
admet-648	132	11	-	-	NOUN
admet-648	132	12	day	day	NOUN
admet-648	132	13	)	)	PUNCT
admet-648	132	14	were	be	AUX
admet-648	132	15	found	find	VERB
admet-648	132	16	to	to	PART
admet-648	132	17	be	be	AUX
admet-648	132	18	within	within	ADP
admet-648	132	19	the	the	DET
admet-648	132	20	accepted	accepted	ADJ
admet-648	132	21	variable	variable	ADJ
admet-648	132	22	limits	limit	NOUN
admet-648	132	23	.	.	PUNCT
admet-648	133	1	table	table	NOUN
admet-648	133	2	1	1	NUM
admet-648	133	3	.	.	PUNCT
admet-648	133	4	precision	precision	NOUN
admet-648	133	5	,	,	PUNCT
admet-648	133	6	accuracy	accuracy	NOUN
admet-648	133	7	,	,	PUNCT
admet-648	133	8	recovery	recovery	NOUN
admet-648	133	9	and	and	CCONJ
admet-648	133	10	matrix	matrix	NOUN
admet-648	133	11	effect	effect	NOUN
admet-648	133	12	for	for	ADP
admet-648	133	13	determination	determination	NOUN
admet-648	133	14	of	of	ADP
admet-648	133	15	ivosidenib	ivosidenib	NOUN
admet-648	133	16	quality	quality	NOUN
admet-648	133	17	controls	control	NOUN
admet-648	133	18	in	in	ADP
admet-648	133	19	mice	mice	NOUN
admet-648	133	20	plasma	plasma	NOUN
admet-648	133	21	lloq	lloq	PROPN
admet-648	133	22	qc	qc	PROPN
admet-648	133	23	(	(	PUNCT
admet-648	133	24	1.10	1.10	NUM
admet-648	133	25	ng	ng	PROPN
admet-648	133	26	/	/	SYM
admet-648	133	27	ml	ml	NOUN
admet-648	133	28	)	)	PUNCT
admet-648	133	29	lqc	lqc	NOUN
admet-648	133	30	(	(	PUNCT
admet-648	133	31	3.29	3.29	NUM
admet-648	133	32	ng	ng	NOUN
admet-648	133	33	/	/	SYM
admet-648	133	34	ml	ml	NOUN
admet-648	133	35	)	)	PUNCT
admet-648	133	36	mqc	mqc	NOUN
admet-648	133	37	(	(	PUNCT
admet-648	133	38	1715	1715	NUM
admet-648	133	39	ng	ng	NOUN
admet-648	133	40	/	/	SYM
admet-648	133	41	ml	ml	PROPN
admet-648	133	42	)	)	PUNCT
admet-648	133	43	hqc	hqc	PROPN
admet-648	133	44	(	(	PUNCT
admet-648	133	45	2607	2607	NUM
admet-648	133	46	ng	ng	PROPN
admet-648	133	47	/	/	SYM
admet-648	133	48	ml	ml	NOUN
admet-648	133	49	)	)	PUNCT
admet-648	133	50	intra	intra	ADJ
admet-648	134	1	-	-	NOUN
admet-648	134	2	day	day	NOUN
admet-648	134	3	(	(	PUNCT
admet-648	134	4	n=6	n=6	NOUN
admet-648	134	5	)	)	PUNCT
admet-648	134	6	mean	mean	VERB
admet-648	134	7	±	±	NUM
admet-648	134	8	s.d	s.d	VERB
admet-648	134	9	1.09	1.09	NUM
admet-648	134	10	±	±	NUM
admet-648	134	11	0.11	0.11	NUM
admet-648	134	12	3.20	3.20	NUM
admet-648	134	13	±	±	NUM
admet-648	134	14	0.28	0.28	NUM
admet-648	134	15	1631	1631	NUM
admet-648	134	16	±	±	NUM
admet-648	134	17	96.2	96.2	NUM
admet-648	134	18	2582	2582	NUM
admet-648	134	19	±	±	NUM
admet-648	134	20	188	188	NUM
admet-648	134	21	precision	precision	NOUN
admet-648	134	22	(	(	PUNCT
admet-648	134	23	%	%	INTJ
admet-648	134	24	rsd	rsd	NOUN
admet-648	134	25	)	)	PUNCT
admet-648	134	26	9.91	9.91	NUM
admet-648	134	27	8.86	8.86	NUM
admet-648	134	28	5.72	5.72	NUM
admet-648	134	29	7.31	7.31	NUM
admet-648	134	30	accuracy	accuracy	NOUN
admet-648	134	31	(	(	PUNCT
admet-648	134	32	%	%	INTJ
admet-648	134	33	re	re	NOUN
admet-648	134	34	)	)	PUNCT
admet-648	134	35	0.99	0.99	NUM
admet-648	134	36	0.97	0.97	NUM
admet-648	134	37	0.98	0.98	NUM
admet-648	134	38	0.99	0.99	NUM
admet-648	134	39	inter	inter	NOUN
admet-648	134	40	-	-	NOUN
admet-648	134	41	day	day	NOUN
admet-648	134	42	(	(	PUNCT
admet-648	134	43	n=24	n=24	PROPN
admet-648	134	44	)	)	PUNCT
admet-648	134	45	mean	mean	VERB
admet-648	135	1	±	±	NUM
admet-648	135	2	s.d	s.d	PROPN
admet-648	135	3	1.10	1.10	NUM
admet-648	135	4	±	±	NUM
admet-648	135	5	0.12	0.12	NUM
admet-648	135	6	3.19	3.19	NUM
admet-648	135	7	±	±	NUM
admet-648	135	8	0.27	0.27	NUM
admet-648	135	9	1634	1634	NUM
admet-648	135	10	±	±	NUM
admet-648	135	11	96.4	96.4	NUM
admet-648	135	12	2588	2588	NUM
admet-648	135	13	±	±	NUM
admet-648	135	14	188	188	NUM
admet-648	135	15	precision	precision	NOUN
admet-648	135	16	(	(	PUNCT
admet-648	135	17	%	%	INTJ
admet-648	135	18	rsd	rsd	NOUN
admet-648	135	19	)	)	PUNCT
admet-648	135	20	10.7	10.7	NUM
admet-648	135	21	8.48	8.48	NUM
admet-648	135	22	5.90	5.90	NUM
admet-648	135	23	7.25	7.25	NUM
admet-648	135	24	accuracy	accuracy	NOUN
admet-648	135	25	(	(	PUNCT
admet-648	135	26	%	%	INTJ
admet-648	135	27	re	re	NOUN
admet-648	135	28	)	)	PUNCT
admet-648	135	29	1.00	1.00	NUM
admet-648	135	30	0.97	0.97	NUM
admet-648	135	31	0.95	0.95	NUM
admet-648	135	32	0.99	0.99	NUM
admet-648	135	33	%	%	NOUN
admet-648	135	34	re	re	ADP
admet-648	135	35	:	:	PUNCT
admet-648	135	36	relative	relative	ADJ
admet-648	135	37	error	error	NOUN
admet-648	135	38	(	(	PUNCT
admet-648	135	39	measured	measure	VERB
admet-648	135	40	value	value	NOUN
admet-648	135	41	/	/	SYM
admet-648	135	42	actual	actual	ADJ
admet-648	135	43	value	value	NOUN
admet-648	135	44	×100	×100	NOUN
admet-648	135	45	)	)	PUNCT
admet-648	135	46	rsd	rsd	NOUN
admet-648	135	47	:	:	PUNCT
admet-648	135	48	relative	relative	ADJ
admet-648	135	49	standard	standard	ADJ
admet-648	135	50	deviation	deviation	NOUN
admet-648	135	51	(	(	PUNCT
admet-648	135	52	sd	sd	PART
admet-648	135	53	×	×	NOUN
admet-648	135	54	100	100	NUM
admet-648	135	55	/	/	SYM
admet-648	135	56	mean	mean	ADJ
admet-648	135	57	)	)	PUNCT
admet-648	135	58	sd	sd	NOUN
admet-648	135	59	:	:	PUNCT
admet-648	135	60	standard	standard	ADJ
admet-648	135	61	deviation	deviation	NOUN
admet-648	135	62	stability	stability	NOUN
admet-648	135	63	the	the	DET
admet-648	135	64	predicted	predict	VERB
admet-648	135	65	concentrations	concentration	NOUN
admet-648	135	66	for	for	ADP
admet-648	135	67	ivosidenib	ivosidenib	NOUN
admet-648	135	68	at	at	ADP
admet-648	135	69	3.29	3.29	NUM
admet-648	135	70	ng	ng	NOUN
admet-648	135	71	/	/	SYM
admet-648	135	72	ml	ml	PROPN
admet-648	135	73	(	(	PUNCT
admet-648	135	74	lqc	lqc	PROPN
admet-648	135	75	)	)	PUNCT
admet-648	135	76	and	and	CCONJ
admet-648	135	77	2607	2607	NUM
admet-648	135	78	ng	ng	PROPN
admet-648	135	79	/	/	SYM
admet-648	135	80	ml	ml	PROPN
admet-648	135	81	(	(	PUNCT
admet-648	135	82	hqc	hqc	INTJ
admet-648	135	83	)	)	PUNCT
admet-648	135	84	samples	sample	NOUN
admet-648	135	85	in	in	ADP
admet-648	135	86	a	a	DET
admet-648	135	87	battery	battery	NOUN
admet-648	135	88	of	of	ADP
admet-648	135	89	stability	stability	NOUN
admet-648	135	90	tests	test	VERB
admet-648	135	91	namely	namely	ADV
admet-648	135	92	in	in	ADP
admet-648	135	93	-	-	PUNCT
admet-648	135	94	injector	injector	NOUN
admet-648	135	95	(	(	PUNCT
admet-648	135	96	24	24	NUM
admet-648	135	97	h	h	NOUN
admet-648	135	98	)	)	PUNCT
admet-648	135	99	,	,	PUNCT
admet-648	135	100	bench	bench	NOUN
admet-648	135	101	-	-	PUNCT
admet-648	135	102	top	top	NOUN
admet-648	135	103	(	(	PUNCT
admet-648	135	104	6	6	NUM
admet-648	135	105	h	h	NOUN
admet-648	135	106	)	)	PUNCT
admet-648	135	107	,	,	PUNCT
admet-648	135	108	repeated	repeat	VERB
admet-648	135	109	three	three	NUM
admet-648	135	110	freeze	freeze	NOUN
admet-648	135	111	/	/	SYM
admet-648	135	112	thaw	thaw	NOUN
admet-648	135	113	cycles	cycle	NOUN
admet-648	135	114	and	and	CCONJ
admet-648	135	115	freezer	freezer	NOUN
admet-648	135	116	stability	stability	NOUN
admet-648	135	117	at	at	ADP
admet-648	135	118	-80	-80	PUNCT
admet-648	135	119			PROPN
admet-648	135	120	10	10	NUM
admet-648	135	121	°	°	ADP
admet-648	135	122	c	c	NOUN
admet-648	135	123	for	for	ADP
admet-648	135	124	30	30	NUM
admet-648	135	125	days	day	NOUN
admet-648	135	126	are	be	AUX
admet-648	135	127	shown	show	VERB
admet-648	135	128	in	in	ADP
admet-648	135	129	table	table	NOUN
admet-648	135	130	2	2	NUM
admet-648	135	131	.	.	PUNCT
admet-648	136	1	the	the	DET
admet-648	136	2	results	result	NOUN
admet-648	136	3	were	be	AUX
admet-648	136	4	found	find	VERB
admet-648	136	5	to	to	PART
admet-648	136	6	be	be	AUX
admet-648	136	7	within	within	ADP
admet-648	136	8	the	the	DET
admet-648	136	9	assay	assay	NOUN
admet-648	136	10	variability	variability	NOUN
admet-648	136	11	limits	limit	NOUN
admet-648	136	12	during	during	ADP
admet-648	136	13	the	the	DET
admet-648	136	14	entire	entire	ADJ
admet-648	136	15	process	process	NOUN
admet-648	136	16	.	.	PUNCT
admet-648	137	1	table	table	NOUN
admet-648	137	2	2	2	NUM
admet-648	137	3	.	.	PUNCT
admet-648	137	4	stability	stability	NOUN
admet-648	137	5	data	datum	NOUN
admet-648	137	6	of	of	ADP
admet-648	137	7	ivosidenib	ivosidenib	NOUN
admet-648	137	8	quality	quality	NOUN
admet-648	137	9	controls	control	NOUN
admet-648	137	10	in	in	ADP
admet-648	137	11	mice	mice	NOUN
admet-648	137	12	plasma	plasma	NOUN
admet-648	137	13	nominal	nominal	ADJ
admet-648	137	14	concentration	concentration	NOUN
admet-648	137	15	(	(	PUNCT
admet-648	137	16	ng	ng	NOUN
admet-648	137	17	/	/	SYM
admet-648	137	18	ml	ml	NOUN
admet-648	137	19	)	)	PUNCT
admet-648	137	20	stability	stability	NOUN
admet-648	137	21	mean	mean	VERB
admet-648	137	22	±	±	NUM
admet-648	137	23	sd	sd	ADP
admet-648	137	24	a	a	DET
admet-648	137	25	n	n	NOUN
admet-648	137	26	=	=	SYM
admet-648	137	27	6	6	NUM
admet-648	137	28	(	(	PUNCT
admet-648	137	29	ng	ng	PROPN
admet-648	137	30	/	/	SYM
admet-648	137	31	ml	ml	NOUN
admet-648	137	32	)	)	PUNCT
admet-648	137	33	accuracy	accuracy	NOUN
admet-648	137	34	(	(	PUNCT
admet-648	137	35	%	%	INTJ
admet-648	137	36	)	)	PUNCT
admet-648	137	37	b	b	NOUN
admet-648	137	38	precision	precision	NOUN
admet-648	137	39	(	(	PUNCT
admet-648	137	40	%	%	NOUN
admet-648	137	41	rsd	rsd	NOUN
admet-648	137	42	)	)	PUNCT
admet-648	137	43	3.29	3.29	NUM
admet-648	137	44	0	0	NUM
admet-648	137	45	h	h	NOUN
admet-648	137	46	6	6	NUM
admet-648	137	47	h	h	NOUN
admet-648	137	48	(	(	PUNCT
admet-648	137	49	bench	bench	NOUN
admet-648	137	50	-	-	PUNCT
admet-648	137	51	top	top	NOUN
admet-648	137	52	)	)	PUNCT
admet-648	137	53	24	24	NUM
admet-648	137	54	h	h	NOUN
admet-648	137	55	(	(	PUNCT
admet-648	137	56	in	in	ADP
admet-648	137	57	-	-	PUNCT
admet-648	137	58	injector	injector	NOUN
admet-648	137	59	)	)	PUNCT
admet-648	137	60	freeze	freeze	NOUN
admet-648	137	61	-	-	PUNCT
admet-648	137	62	thaw	thaw	NOUN
admet-648	137	63	30	30	NUM
admet-648	137	64	day	day	NOUN
admet-648	137	65	at	at	ADP
admet-648	137	66	-80	-80	NOUN
admet-648	137	67	°	°	NOUN
admet-648	137	68	c	c	NOUN
admet-648	137	69	3.21	3.21	NUM
admet-648	137	70	±	±	NUM
admet-648	137	71	0.39	0.39	NUM
admet-648	137	72	3.13	3.13	NUM
admet-648	137	73	±	±	NUM
admet-648	137	74	0.40	0.40	NUM
admet-648	137	75	2.98	2.98	NUM
admet-648	137	76	±	±	NUM
admet-648	137	77	0.20	0.20	NUM
admet-648	137	78	3.39	3.39	NUM
admet-648	137	79	±	±	NUM
admet-648	137	80	0.50	0.50	NUM
admet-648	137	81	3.32	3.32	NUM
admet-648	137	82	±	±	NUM
admet-648	137	83	0.33	0.33	NUM
admet-648	137	84	na	na	ADP
admet-648	137	85	97.6	97.6	NUM
admet-648	137	86	92.9	92.9	NUM
admet-648	137	87	106	106	NUM
admet-648	137	88	103	103	NUM
admet-648	137	89	12.1	12.1	NUM
admet-648	137	90	12.6	12.6	NUM
admet-648	137	91	6.87	6.87	NUM
admet-648	137	92	14.8	14.8	NUM
admet-648	137	93	10.1	10.1	NUM
admet-648	137	94	2607	2607	NUM
admet-648	137	95	0	0	NUM
admet-648	137	96	h	h	NOUN
admet-648	137	97	6	6	NUM
admet-648	137	98	h	h	NOUN
admet-648	137	99	(	(	PUNCT
admet-648	137	100	bench	bench	NOUN
admet-648	137	101	-	-	PUNCT
admet-648	137	102	top	top	NOUN
admet-648	137	103	)	)	PUNCT
admet-648	137	104	24	24	NUM
admet-648	137	105	h	h	NOUN
admet-648	137	106	(	(	PUNCT
admet-648	137	107	in	in	ADP
admet-648	137	108	-	-	PUNCT
admet-648	137	109	injector	injector	NOUN
admet-648	137	110	)	)	PUNCT
admet-648	137	111	freeze	freeze	NOUN
admet-648	137	112	-	-	PUNCT
admet-648	137	113	thaw	thaw	NOUN
admet-648	137	114	30	30	NUM
admet-648	137	115	day	day	NOUN
admet-648	137	116	at	at	ADP
admet-648	137	117	-80	-80	NOUN
admet-648	137	118	°	°	NOUN
admet-648	137	119	c	c	NOUN
admet-648	137	120	2687	2687	NUM
admet-648	137	121	±156	±156	NOUN
admet-648	137	122	2709	2709	NUM
admet-648	137	123	±76.4	±76.4	PROPN
admet-648	137	124	2357	2357	NUM
admet-648	137	125	±108	±108	NOUN
admet-648	137	126	2632	2632	NUM
admet-648	137	127	±	±	NUM
admet-648	137	128	110	110	NUM
admet-648	137	129	2609	2609	NUM
admet-648	137	130	±	±	NUM
admet-648	137	131	170	170	NUM
admet-648	137	132	na	na	PROPN
admet-648	137	133	101	101	NUM
admet-648	137	134	87.7	87.7	NUM
admet-648	137	135	98.0	98.0	NUM
admet-648	137	136	97.1	97.1	NUM
admet-648	137	137	4.78	4.78	NUM
admet-648	137	138	2.82	2.82	NUM
admet-648	137	139	4.57	4.57	NUM
admet-648	137	140	4.18	4.18	NUM
admet-648	137	141	6.50	6.50	NUM
admet-648	137	142	a	a	DET
admet-648	137	143	back	back	ADV
admet-648	137	144	-	-	PUNCT
admet-648	137	145	calculated	calculate	VERB
admet-648	137	146	plasma	plasma	NOUN
admet-648	137	147	concentrations	concentration	NOUN
admet-648	137	148	b	b	PROPN
admet-648	137	149	(	(	PUNCT
admet-648	137	150	mean	mean	ADJ
admet-648	137	151	assayed	assayed	ADJ
admet-648	137	152	concentration	concentration	NOUN
admet-648	137	153	/	/	SYM
admet-648	137	154	mean	mean	ADJ
admet-648	137	155	assayed	assayed	ADJ
admet-648	137	156	concentration	concentration	NOUN
admet-648	137	157	at	at	ADP
admet-648	137	158	0	0	NUM
admet-648	137	159	h	h	NOUN
admet-648	137	160	)	)	PUNCT
admet-648	137	161	×	×	NOUN
admet-648	137	162	100	100	NUM
admet-648	137	163	%	%	NOUN
admet-648	137	164	re	re	ADP
admet-648	137	165	:	:	PUNCT
admet-648	137	166	relative	relative	ADJ
admet-648	137	167	error	error	NOUN
admet-648	137	168	(	(	PUNCT
admet-648	137	169	measured	measure	VERB
admet-648	137	170	value	value	NOUN
admet-648	137	171	/	/	SYM
admet-648	137	172	actual	actual	ADJ
admet-648	137	173	value	value	NOUN
admet-648	137	174	×	×	PROPN
admet-648	137	175	100	100	NUM
admet-648	137	176	)	)	PUNCT
admet-648	137	177	rsd	rsd	NOUN
admet-648	137	178	:	:	PUNCT
admet-648	137	179	relative	relative	ADJ
admet-648	137	180	standard	standard	ADJ
admet-648	137	181	deviation	deviation	NOUN
admet-648	137	182	(	(	PUNCT
admet-648	137	183	sd	sd	PART
admet-648	137	184	×	×	NOUN
admet-648	137	185	100	100	NUM
admet-648	137	186	/	/	SYM
admet-648	137	187	mean	mean	ADJ
admet-648	137	188	)	)	PUNCT
admet-648	137	189	dilution	dilution	NOUN
admet-648	137	190	effect	effect	NOUN
admet-648	137	191	the	the	DET
admet-648	137	192	accuracy	accuracy	NOUN
admet-648	137	193	and	and	CCONJ
admet-648	137	194	precision	precision	NOUN
admet-648	137	195	of	of	ADP
admet-648	137	196	the	the	DET
admet-648	137	197	nominal	nominal	ADJ
admet-648	137	198	concentration	concentration	NOUN
admet-648	137	199	of	of	ADP
admet-648	137	200	the	the	DET
admet-648	137	201	diluted	dilute	VERB
admet-648	137	202	plasma	plasma	NOUN
admet-648	137	203	samples	sample	NOUN
admet-648	137	204	were	be	AUX
admet-648	137	205	within	within	ADP
admet-648	137	206	0.79	0.79	NUM
admet-648	137	207	%	%	NOUN
admet-648	137	208	and	and	CCONJ
admet-648	137	209	3.34	3.34	NUM
admet-648	137	210	%	%	NOUN
admet-648	137	211	,	,	PUNCT
admet-648	137	212	which	which	PRON
admet-648	137	213	show	show	VERB
admet-648	137	214	the	the	DET
admet-648	137	215	ability	ability	NOUN
admet-648	137	216	to	to	PART
admet-648	137	217	dilute	dilute	VERB
admet-648	137	218	samples	sample	NOUN
admet-648	137	219	up	up	ADP
admet-648	137	220	to	to	ADP
admet-648	137	221	a	a	DET
admet-648	137	222	dilution	dilution	NOUN
admet-648	137	223	factor	factor	NOUN
admet-648	137	224	of	of	ADP
admet-648	137	225	10	10	NUM
admet-648	137	226	-	-	ADJ
admet-648	137	227	fold	fold	ADJ
admet-648	137	228	in	in	ADP
admet-648	137	229	a	a	DET
admet-648	137	230	linear	linear	ADJ
admet-648	137	231	fashion	fashion	NOUN
admet-648	137	232	.	.	PUNCT
admet-648	138	1	r.	r.	PROPN
admet-648	138	2	mullangi	mullangi	PROPN
admet-648	138	3	et	et	PROPN
admet-648	138	4	al	al	PROPN
admet-648	138	5	.	.	PROPN
admet-648	138	6	admet	admet	PROPN
admet-648	138	7	&	&	CCONJ
admet-648	138	8	dmpk	dmpk	PROPN
admet-648	138	9	7(2	7(2	NUM
admet-648	138	10	)	)	PUNCT
admet-648	138	11	(	(	PUNCT
admet-648	138	12	2019	2019	NUM
admet-648	138	13	)	)	PUNCT
admet-648	138	14	131	131	NUM
admet-648	138	15	-	-	SYM
admet-648	138	16	139	139	NUM
admet-648	138	17	138	138	NUM
admet-648	138	18	pharmacokinetic	pharmacokinetic	ADJ
admet-648	138	19	study	study	NOUN
admet-648	138	20	the	the	DET
admet-648	138	21	sensitivity	sensitivity	NOUN
admet-648	138	22	and	and	CCONJ
admet-648	138	23	specificity	specificity	NOUN
admet-648	138	24	of	of	ADP
admet-648	138	25	the	the	DET
admet-648	138	26	validated	validate	VERB
admet-648	138	27	assay	assay	NOUN
admet-648	138	28	was	be	AUX
admet-648	138	29	found	find	VERB
admet-648	138	30	to	to	PART
admet-648	138	31	be	be	AUX
admet-648	138	32	sufficient	sufficient	ADJ
admet-648	138	33	for	for	ADP
admet-648	138	34	accurately	accurately	ADV
admet-648	138	35	characterizing	characterize	VERB
admet-648	138	36	the	the	DET
admet-648	138	37	pharmacokinetics	pharmacokinetic	NOUN
admet-648	138	38	of	of	ADP
admet-648	138	39	ivosidenib	ivosidenib	NOUN
admet-648	138	40	in	in	ADP
admet-648	138	41	mice	mice	NOUN
admet-648	138	42	plasma	plasma	NOUN
admet-648	138	43	following	follow	VERB
admet-648	138	44	intravenous	intravenous	ADJ
admet-648	138	45	and	and	CCONJ
admet-648	138	46	oral	oral	ADJ
admet-648	138	47	administration	administration	NOUN
admet-648	138	48	.	.	PUNCT
admet-648	139	1	the	the	DET
admet-648	139	2	estimates	estimate	NOUN
admet-648	139	3	of	of	ADP
admet-648	139	4	the	the	DET
admet-648	139	5	pharmacokinetic	pharmacokinetic	ADJ
admet-648	139	6	parameters	parameter	NOUN
admet-648	139	7	are	be	AUX
admet-648	139	8	summarized	summarize	VERB
admet-648	139	9	in	in	ADP
admet-648	139	10	table	table	NOUN
admet-648	139	11	3	3	NUM
admet-648	139	12	.	.	PUNCT
admet-648	140	1	the	the	DET
admet-648	140	2	mean	mean	ADJ
admet-648	140	3	plasma	plasma	NOUN
admet-648	140	4	concentration	concentration	NOUN
admet-648	140	5	versus	versus	ADP
admet-648	140	6	time	time	NOUN
admet-648	140	7	profiles	profile	NOUN
admet-648	140	8	for	for	ADP
admet-648	140	9	ivosidenib	ivosidenib	NOUN
admet-648	140	10	following	follow	VERB
admet-648	140	11	single	single	ADJ
admet-648	140	12	oral	oral	ADJ
admet-648	140	13	and	and	CCONJ
admet-648	140	14	intravenous	intravenous	ADJ
admet-648	140	15	route	route	NOUN
admet-648	140	16	is	be	AUX
admet-648	140	17	depicted	depict	VERB
admet-648	140	18	in	in	ADP
admet-648	140	19	figures	figure	NOUN
admet-648	140	20	3a	3a	NUM
admet-648	140	21	and	and	CCONJ
admet-648	140	22	3b	3b	NUM
admet-648	140	23	,	,	PUNCT
admet-648	140	24	respectively	respectively	ADV
admet-648	140	25	.	.	PUNCT
admet-648	141	1	following	follow	VERB
admet-648	141	2	intravenous	intravenous	ADJ
admet-648	141	3	administration	administration	NOUN
admet-648	141	4	,	,	PUNCT
admet-648	141	5	the	the	DET
admet-648	141	6	plasma	plasma	NOUN
admet-648	141	7	concentrations	concentration	NOUN
admet-648	141	8	decreased	decrease	VERB
admet-648	141	9	in	in	ADP
admet-648	141	10	a	a	DET
admet-648	141	11	mono	mono	NOUN
admet-648	141	12	-	-	PUNCT
admet-648	141	13	exponential	exponential	ADJ
admet-648	141	14	manner	manner	NOUN
admet-648	141	15	.	.	PUNCT
admet-648	142	1	ivosidenib	ivosidenib	NOUN
admet-648	142	2	was	be	AUX
admet-648	142	3	quantifiable	quantifiable	ADJ
admet-648	142	4	up	up	ADP
admet-648	142	5	to	to	PART
admet-648	142	6	24	24	NUM
admet-648	142	7	h	h	NOUN
admet-648	142	8	postdosing	postdose	VERB
admet-648	142	9	by	by	ADP
admet-648	142	10	intravenous	intravenous	ADJ
admet-648	142	11	route	route	NOUN
admet-648	142	12	.	.	PUNCT
admet-648	143	1	the	the	DET
admet-648	143	2	auc0-	auc0-	NOUN
admet-648	143	3	(	(	PUNCT
admet-648	143	4	area	area	NOUN
admet-648	143	5	under	under	ADP
admet-648	143	6	curve	curve	NOUN
admet-648	143	7	from	from	ADP
admet-648	143	8	time	time	NOUN
admet-648	143	9	zero	zero	NUM
admet-648	143	10	to	to	ADP
admet-648	143	11	infinity	infinity	NOUN
admet-648	143	12	)	)	PUNCT
admet-648	143	13	was	be	AUX
admet-648	143	14	found	find	VERB
admet-648	143	15	to	to	PART
admet-648	143	16	be	be	AUX
admet-648	143	17	4967	4967	NUM
admet-648	143	18	ng	ng	PROPN
admet-648	143	19			PROPN
admet-648	143	20	h	h	PROPN
admet-648	143	21	/	/	SYM
admet-648	143	22	ml	ml	PROPN
admet-648	143	23	.	.	PUNCT
admet-648	144	1	the	the	DET
admet-648	144	2	in	in	ADP
admet-648	144	3	vivo	vivo	ADJ
admet-648	144	4	clearance	clearance	NOUN
admet-648	144	5	(	(	PUNCT
admet-648	144	6	cl	cl	NOUN
admet-648	144	7	)	)	PUNCT
admet-648	144	8	and	and	CCONJ
admet-648	144	9	volume	volume	NOUN
admet-648	144	10	of	of	ADP
admet-648	144	11	distribution	distribution	NOUN
admet-648	144	12	(	(	PUNCT
admet-648	144	13	vd	vd	NOUN
admet-648	144	14	)	)	PUNCT
admet-648	144	15	was	be	AUX
admet-648	144	16	found	find	VERB
admet-648	144	17	to	to	PART
admet-648	144	18	be	be	AUX
admet-648	144	19	6.85	6.85	NUM
admet-648	144	20	ml	ml	NOUN
admet-648	144	21	/	/	SYM
admet-648	144	22	min	min	NOUN
admet-648	144	23	/	/	SYM
admet-648	144	24	kg	kg	PROPN
admet-648	144	25	and	and	CCONJ
admet-648	144	26	1.70	1.70	NUM
admet-648	144	27	l	l	NOUN
admet-648	144	28	/	/	SYM
admet-648	144	29	kg	kg	PROPN
admet-648	144	30	,	,	PUNCT
admet-648	144	31	indicating	indicate	VERB
admet-648	144	32	that	that	SCONJ
admet-648	144	33	ivosidenib	ivosidenib	NOUN
admet-648	144	34	has	have	VERB
admet-648	144	35	low	low	ADJ
admet-648	144	36	clearance	clearance	NOUN
admet-648	144	37	and	and	CCONJ
admet-648	144	38	moderate	moderate	ADJ
admet-648	144	39	volume	volume	NOUN
admet-648	144	40	of	of	ADP
admet-648	144	41	distribution	distribution	NOUN
admet-648	144	42	.	.	PUNCT
admet-648	145	1	after	after	ADP
admet-648	145	2	oral	oral	ADJ
admet-648	145	3	administration	administration	NOUN
admet-648	145	4	of	of	ADP
admet-648	145	5	ivosidenib	ivosidenib	NOUN
admet-648	145	6	to	to	ADP
admet-648	145	7	mice	mouse	NOUN
admet-648	145	8	,	,	PUNCT
admet-648	145	9	maximum	maximum	ADJ
admet-648	145	10	concentration	concentration	NOUN
admet-648	145	11	in	in	ADP
admet-648	145	12	plasma	plasma	NOUN
admet-648	145	13	(	(	PUNCT
admet-648	145	14	cmax	cmax	NOUN
admet-648	145	15	:	:	PUNCT
admet-648	145	16	1668	1668	NUM
admet-648	145	17	ng	ng	NOUN
admet-648	145	18	/	/	SYM
admet-648	145	19	ml	ml	PROPN
admet-648	145	20	)	)	PUNCT
admet-648	145	21	attained	attain	VERB
admet-648	145	22	at	at	ADP
admet-648	145	23	0.50	0.50	NUM
admet-648	145	24	h	h	NOUN
admet-648	145	25	(	(	PUNCT
admet-648	145	26	tmax	tmax	ADV
admet-648	145	27	)	)	PUNCT
admet-648	145	28	indicating	indicate	VERB
admet-648	145	29	rapid	rapid	ADJ
admet-648	145	30	absorption	absorption	NOUN
admet-648	145	31	from	from	ADP
admet-648	145	32	gastrointestinal	gastrointestinal	ADJ
admet-648	145	33	tract	tract	NOUN
admet-648	145	34	.	.	PUNCT
admet-648	146	1	ivosidenib	ivosidenib	NOUN
admet-648	146	2	was	be	AUX
admet-648	146	3	quantifiable	quantifiable	ADJ
admet-648	146	4	up	up	ADP
admet-648	146	5	to	to	PART
admet-648	146	6	36	36	NUM
admet-648	146	7	h	h	NOUN
admet-648	146	8	post	post	NOUN
admet-648	146	9	oral	oral	ADJ
admet-648	146	10	dosing	dosing	NOUN
admet-648	146	11	.	.	PUNCT
admet-648	147	1	the	the	DET
admet-648	147	2	auc(0-	auc(0-	NOUN
admet-648	147	3	)	)	PUNCT
admet-648	147	4	was	be	AUX
admet-648	147	5	found	find	VERB
admet-648	147	6	to	to	PART
admet-648	147	7	be	be	AUX
admet-648	147	8	7462	7462	NUM
admet-648	147	9	ng	ng	PROPN
admet-648	147	10			PROPN
admet-648	147	11	h	h	PROPN
admet-648	147	12	/	/	SYM
admet-648	147	13	ml	ml	PROPN
admet-648	147	14	.	.	PUNCT
admet-648	148	1	the	the	DET
admet-648	148	2	terminal	terminal	ADJ
admet-648	148	3	half	half	ADJ
admet-648	148	4	-	-	PUNCT
admet-648	148	5	life	life	NOUN
admet-648	148	6	was	be	AUX
admet-648	148	7	2.87	2.87	NUM
admet-648	148	8	and	and	CCONJ
admet-648	148	9	4.06	4.06	NUM
admet-648	148	10	h	h	NOUN
admet-648	148	11	,	,	PUNCT
admet-648	148	12	by	by	ADP
admet-648	148	13	intravenous	intravenous	ADJ
admet-648	148	14	and	and	CCONJ
admet-648	148	15	oral	oral	ADJ
admet-648	148	16	routes	route	NOUN
admet-648	148	17	,	,	PUNCT
admet-648	148	18	respectively	respectively	ADV
admet-648	148	19	.	.	PUNCT
admet-648	149	1	the	the	DET
admet-648	149	2	absolute	absolute	ADJ
admet-648	149	3	oral	oral	ADJ
admet-648	149	4	bioavailability	bioavailability	NOUN
admet-648	149	5	was	be	AUX
admet-648	149	6	61	61	NUM
admet-648	149	7	%	%	NOUN
admet-648	149	8	.	.	PUNCT
admet-648	150	1	table	table	NOUN
admet-648	150	2	3	3	NUM
admet-648	150	3	.	.	PUNCT
admet-648	150	4	pharmacokinetic	pharmacokinetic	ADJ
admet-648	150	5	parameters	parameter	NOUN
admet-648	150	6	of	of	ADP
admet-648	150	7	ivosidenib	ivosidenib	NOUN
admet-648	150	8	in	in	ADP
admet-648	150	9	mice	mouse	NOUN
admet-648	150	10	parameter	parameter	PROPN
admet-648	150	11	intravenous	intravenous	PROPN
admet-648	150	12	oral	oral	ADJ
admet-648	150	13	dose	dose	NOUN
admet-648	150	14	(	(	PUNCT
admet-648	150	15	mg	mg	PROPN
admet-648	150	16	/	/	SYM
admet-648	150	17	kg	kg	NOUN
admet-648	150	18	)	)	PUNCT
admet-648	150	19	2.0	2.0	NUM
admet-648	150	20	5.0	5.0	NUM
admet-648	150	21	auc0-∞	auc0-∞	NUM
admet-648	150	22	(	(	PUNCT
admet-648	150	23	ng	ng	PROPN
admet-648	150	24	×	×	PROPN
admet-648	150	25	h	h	PROPN
admet-648	150	26	/	/	SYM
admet-648	150	27	ml	ml	NOUN
admet-648	150	28	)	)	PUNCT
admet-648	150	29	4967	4967	NUM
admet-648	150	30	7462	7462	NUM
admet-648	150	31	c0	c0	NOUN
admet-648	150	32	/	/	SYM
admet-648	150	33	cmax	cmax	NOUN
admet-648	150	34	(	(	PUNCT
admet-648	150	35	ng	ng	NOUN
admet-648	150	36	/	/	SYM
admet-648	150	37	ml	ml	NOUN
admet-648	150	38	)	)	PUNCT
admet-648	150	39	6085	6085	NUM
admet-648	150	40	1668	1668	NUM
admet-648	150	41	tmax	tmax	ADP
admet-648	150	42	(	(	PUNCT
admet-648	150	43	h	h	NOUN
admet-648	150	44	)	)	PUNCT
admet-648	151	1	--0.50	--0.50	PROPN
admet-648	151	2	t1/2	t1/2	PROPN
admet-648	151	3	(	(	PUNCT
admet-648	151	4	h	h	NOUN
admet-648	151	5	)	)	PUNCT
admet-648	151	6	2.87	2.87	NUM
admet-648	151	7	4.06	4.06	NUM
admet-648	151	8	cl	cl	NOUN
admet-648	151	9	(	(	PUNCT
admet-648	151	10	ml	ml	NOUN
admet-648	151	11	/	/	SYM
admet-648	151	12	min	min	NOUN
admet-648	151	13	/	/	SYM
admet-648	151	14	kg	kg	NOUN
admet-648	151	15	)	)	PUNCT
admet-648	151	16	6.85	6.85	NUM
admet-648	151	17	--	--	PUNCT
admet-648	151	18	vd	vd	NOUN
admet-648	151	19	(	(	PUNCT
admet-648	151	20	l	l	NOUN
admet-648	151	21	)	)	PUNCT
admet-648	151	22	1.70	1.70	NUM
admet-648	151	23	--	--	PUNCT
admet-648	151	24	a	a	X
admet-648	151	25	)	)	PUNCT
admet-648	151	26	b	b	NOUN
admet-648	151	27	)	)	PUNCT
admet-648	151	28	time	time	NOUN
admet-648	151	29	(	(	PUNCT
admet-648	151	30	h	h	NOUN
admet-648	151	31	)	)	PUNCT
admet-648	151	32	m	m	VERB
admet-648	151	33	ea	ea	NOUN
admet-648	151	34	n	n	CCONJ
admet-648	151	35			PROPN
admet-648	151	36	s	s	PART
admet-648	151	37	.d	.d	NOUN
admet-648	151	38	(	(	PUNCT
admet-648	151	39	n	n	PRON
admet-648	151	40	g	g	NOUN
admet-648	151	41	/m	/m	PUNCT
admet-648	151	42	l	l	NOUN
admet-648	151	43	)	)	PUNCT
admet-648	152	1	c	c	X
admet-648	152	2	o	o	NOUN
admet-648	153	1	n	n	ADP
admet-648	153	2	c	c	NOUN
admet-648	153	3	e	e	X
admet-648	153	4	n	n	X
admet-648	153	5	tr	tr	DET
admet-648	153	6	a	a	DET
admet-648	153	7	ti	ti	NOUN
admet-648	153	8	o	o	NOUN
admet-648	153	9	n	n	ADP
admet-648	153	10	o	o	NOUN
admet-648	153	11	f	f	NOUN
admet-648	154	1	iv	iv	NUM
admet-648	154	2	o	o	NOUN
admet-648	154	3	si	si	PROPN
admet-648	154	4	d	d	X
admet-648	154	5	e	e	PROPN
admet-648	154	6	n	n	NOUN
admet-648	154	7	ib	ib	NOUN
admet-648	154	8	i	i	PRON
admet-648	154	9	n	n	VERB
admet-648	154	10	m	m	VERB
admet-648	154	11	ic	ic	PROPN
admet-648	154	12	e	e	X
admet-648	154	13	p	p	X
admet-648	154	14	la	la	PROPN
admet-648	154	15	sm	sm	PROPN
admet-648	154	16	a	a	DET
admet-648	154	17	0	0	NUM
admet-648	154	18	4	4	NUM
admet-648	154	19	8	8	NUM
admet-648	154	20	12	12	NUM
admet-648	154	21	16	16	NUM
admet-648	154	22	20	20	NUM
admet-648	154	23	24	24	NUM
admet-648	154	24	1	1	NUM
admet-648	154	25	10	10	NUM
admet-648	154	26	100	100	NUM
admet-648	154	27	1000	1000	NUM
admet-648	154	28	10000	10000	NUM
admet-648	154	29	time	time	NOUN
admet-648	154	30	(	(	PUNCT
admet-648	154	31	h	h	NOUN
admet-648	154	32	)	)	PUNCT
admet-648	154	33	m	m	VERB
admet-648	154	34	e	e	NOUN
admet-648	154	35	a	a	DET
admet-648	154	36	n	n	CCONJ
admet-648	154	37			PROPN
admet-648	154	38	s	s	PART
admet-648	154	39	.d	.d	NOUN
admet-648	154	40	(	(	PUNCT
admet-648	154	41	n	n	PRON
admet-648	154	42	g	g	NOUN
admet-648	154	43	/m	/m	PUNCT
admet-648	154	44	l	l	NOUN
admet-648	154	45	)	)	PUNCT
admet-648	155	1	c	c	X
admet-648	155	2	o	o	NOUN
admet-648	156	1	n	n	ADP
admet-648	156	2	c	c	NOUN
admet-648	156	3	e	e	X
admet-648	156	4	n	n	X
admet-648	156	5	tr	tr	DET
admet-648	156	6	a	a	DET
admet-648	156	7	ti	ti	NOUN
admet-648	156	8	o	o	NOUN
admet-648	156	9	n	n	ADP
admet-648	156	10	o	o	NOUN
admet-648	156	11	f	f	NOUN
admet-648	157	1	iv	iv	NUM
admet-648	157	2	o	o	NOUN
admet-648	157	3	si	si	PROPN
admet-648	157	4	d	d	X
admet-648	157	5	e	e	PROPN
admet-648	157	6	n	n	NOUN
admet-648	157	7	ib	ib	NOUN
admet-648	157	8	i	i	PRON
admet-648	157	9	n	n	VERB
admet-648	157	10	m	m	VERB
admet-648	157	11	ic	ic	PROPN
admet-648	157	12	e	e	X
admet-648	157	13	p	p	X
admet-648	157	14	la	la	PROPN
admet-648	157	15	sm	sm	PROPN
admet-648	157	16	a	a	DET
admet-648	157	17	0	0	NUM
admet-648	157	18	4	4	NUM
admet-648	157	19	8	8	NUM
admet-648	157	20	12	12	NUM
admet-648	157	21	16	16	NUM
admet-648	157	22	20	20	NUM
admet-648	157	23	24	24	NUM
admet-648	157	24	28	28	NUM
admet-648	157	25	32	32	NUM
admet-648	157	26	36	36	NUM
admet-648	157	27	40	40	NUM
admet-648	157	28	44	44	NUM
admet-648	157	29	48	48	NUM
admet-648	157	30	1	1	NUM
admet-648	157	31	10	10	NUM
admet-648	157	32	100	100	NUM
admet-648	157	33	1000	1000	NUM
admet-648	157	34	10000	10000	NUM
admet-648	157	35	figure	figure	NOUN
admet-648	157	36	3	3	NUM
admet-648	157	37	.	.	PUNCT
admet-648	158	1	mean	mean	VERB
admet-648	158	2	plasma	plasma	NOUN
admet-648	158	3	concentration	concentration	NOUN
admet-648	158	4	-	-	PUNCT
admet-648	158	5	time	time	NOUN
admet-648	158	6	profile	profile	NOUN
admet-648	158	7	of	of	ADP
admet-648	158	8	ivosidenib	ivosidenib	NOUN
admet-648	158	9	following	follow	VERB
admet-648	158	10	(	(	PUNCT
admet-648	158	11	a	a	PRON
admet-648	158	12	)	)	PUNCT
admet-648	158	13	intravenous	intravenous	ADJ
admet-648	158	14	and	and	CCONJ
admet-648	158	15	(	(	PUNCT
admet-648	158	16	b	b	NOUN
admet-648	158	17	)	)	PUNCT
admet-648	158	18	oral	oral	NOUN
admet-648	158	19	dosing	dose	VERB
admet-648	158	20	to	to	PART
admet-648	158	21	mice	mice	VERB
admet-648	158	22	conclusions	conclusion	NOUN
admet-648	158	23	a	a	DET
admet-648	158	24	rapid	rapid	ADJ
admet-648	158	25	,	,	PUNCT
admet-648	158	26	simple	simple	ADJ
admet-648	158	27	,	,	PUNCT
admet-648	158	28	sensitive	sensitive	ADJ
admet-648	158	29	and	and	CCONJ
admet-648	158	30	selective	selective	ADJ
admet-648	158	31	lc	lc	NOUN
admet-648	158	32	-	-	PUNCT
admet-648	158	33	esi	esi	PROPN
admet-648	158	34	-	-	PUNCT
admet-648	158	35	ms	ms	ADJ
admet-648	158	36	/	/	SYM
admet-648	158	37	ms	ms	PROPN
admet-648	158	38	method	method	NOUN
admet-648	158	39	was	be	AUX
admet-648	158	40	developed	develop	VERB
admet-648	158	41	and	and	CCONJ
admet-648	158	42	validated	validate	VERB
admet-648	158	43	for	for	ADP
admet-648	158	44	the	the	DET
admet-648	158	45	determination	determination	NOUN
admet-648	158	46	of	of	ADP
admet-648	158	47	ivosidenib	ivosidenib	NOUN
admet-648	158	48	using	use	VERB
admet-648	158	49	10	10	NUM
admet-648	158	50	µl	µl	ADP
admet-648	158	51	mice	mice	NOUN
admet-648	158	52	plasma	plasma	NOUN
admet-648	158	53	.	.	PUNCT
admet-648	159	1	this	this	DET
admet-648	159	2	method	method	NOUN
admet-648	159	3	demonstrates	demonstrate	VERB
admet-648	159	4	good	good	ADJ
admet-648	159	5	accuracy	accuracy	NOUN
admet-648	159	6	and	and	CCONJ
admet-648	159	7	precision	precision	NOUN
admet-648	159	8	and	and	CCONJ
admet-648	159	9	meets	meet	VERB
admet-648	159	10	us	us	PROPN
admet-648	159	11	fda	fda	PROPN
admet-648	159	12	validation	validation	NOUN
admet-648	159	13	criteria	criterion	NOUN
admet-648	159	14	.	.	PUNCT
admet-648	160	1	to	to	ADP
admet-648	160	2	our	our	PRON
admet-648	160	3	knowledge	knowledge	NOUN
admet-648	160	4	,	,	PUNCT
admet-648	160	5	this	this	PRON
admet-648	160	6	is	be	AUX
admet-648	160	7	the	the	DET
admet-648	160	8	first	first	ADJ
admet-648	160	9	report	report	NOUN
admet-648	160	10	of	of	ADP
admet-648	160	11	an	an	DET
admet-648	160	12	lcadmet	lcadmet	NOUN
admet-648	160	13	&	&	CCONJ
admet-648	160	14	dmpk	dmpk	PROPN
admet-648	160	15	7(2	7(2	NUM
admet-648	160	16	)	)	PUNCT
admet-648	160	17	(	(	PUNCT
admet-648	160	18	2018	2018	NUM
admet-648	160	19	)	)	PUNCT
admet-648	160	20	131	131	NUM
admet-648	160	21	-	-	SYM
admet-648	160	22	139	139	NUM
admet-648	160	23	quantitation	quantitation	NOUN
admet-648	160	24	of	of	ADP
admet-648	160	25	ivosidenib	ivosidenib	NOUN
admet-648	160	26	in	in	ADP
admet-648	160	27	mice	mice	NOUN
admet-648	160	28	plasma	plasma	NOUN
admet-648	160	29	by	by	ADP
admet-648	160	30	lc	lc	PROPN
admet-648	160	31	-	-	PUNCT
admet-648	160	32	esi	esi	PROPN
admet-648	160	33	-	-	PUNCT
admet-648	160	34	ms	ms	PROPN
admet-648	160	35	/	/	SYM
admet-648	160	36	ms	ms	NOUN
admet-648	160	37	doi	doi	PROPN
admet-648	160	38	:	:	PUNCT
admet-648	160	39	10.5599	10.5599	NUM
admet-648	160	40	/	/	SYM
admet-648	160	41	admet.648	admet.648	PROPN
admet-648	160	42	139	139	NUM
admet-648	160	43	ms	ms	PROPN
admet-648	160	44	/	/	SYM
admet-648	160	45	ms	ms	PROPN
admet-648	160	46	method	method	NOUN
admet-648	160	47	for	for	ADP
admet-648	160	48	quantification	quantification	NOUN
admet-648	160	49	of	of	ADP
admet-648	160	50	ivosidenib	ivosidenib	NOUN
admet-648	160	51	in	in	ADP
admet-648	160	52	plasma	plasma	NOUN
admet-648	160	53	and	and	CCONJ
admet-648	160	54	successfully	successfully	ADV
admet-648	160	55	applied	apply	VERB
admet-648	160	56	for	for	ADP
admet-648	160	57	a	a	DET
admet-648	160	58	pharmacokinetic	pharmacokinetic	ADJ
admet-648	160	59	study	study	NOUN
admet-648	160	60	in	in	ADP
admet-648	160	61	mice	mouse	NOUN
admet-648	160	62	.	.	PUNCT
admet-648	161	1	conflict	conflict	NOUN
admet-648	161	2	of	of	ADP
admet-648	161	3	interest	interest	NOUN
admet-648	161	4	:	:	PUNCT
admet-648	161	5	the	the	DET
admet-648	161	6	authors	author	NOUN
admet-648	161	7	are	be	AUX
admet-648	161	8	scientists	scientist	NOUN
admet-648	161	9	at	at	ADP
admet-648	161	10	jubilantbiosys	jubilantbiosy	NOUN
admet-648	161	11	.	.	PUNCT
admet-648	162	1	references	reference	NOUN
admet-648	162	2	[	[	X
admet-648	162	3	1	1	X
admet-648	162	4	]	]	X
admet-648	162	5	z.j	z.j	PROPN
admet-648	162	6	.	.	PROPN
admet-648	162	7	reitman	reitman	PROPN
admet-648	162	8	,	,	PUNCT
admet-648	162	9	h.	h.	PROPN
admet-648	162	10	yan	yan	PROPN
admet-648	162	11	h.	h.	PROPN
admet-648	162	12	isocitrate	isocitrate	PROPN
admet-648	162	13	dehydrogenase	dehydrogenase	NOUN
admet-648	162	14	1	1	NUM
admet-648	162	15	and	and	CCONJ
admet-648	162	16	2	2	NUM
admet-648	162	17	mutations	mutation	NOUN
admet-648	162	18	in	in	ADP
admet-648	162	19	cancer	cancer	NOUN
admet-648	162	20	:	:	PUNCT
admet-648	162	21	alterations	alteration	NOUN
admet-648	162	22	at	at	ADP
admet-648	162	23	a	a	DET
admet-648	162	24	crossroads	crossroad	NOUN
admet-648	162	25	of	of	ADP
admet-648	162	26	cellular	cellular	ADJ
admet-648	162	27	metabolism	metabolism	NOUN
admet-648	162	28	.	.	PUNCT
admet-648	163	1	journal	journal	PROPN
admet-648	163	2	of	of	ADP
admet-648	163	3	national	national	PROPN
admet-648	163	4	cancer	cancer	PROPN
admet-648	163	5	institute	institute	PROPN
admet-648	163	6	102	102	NUM
admet-648	163	7	(	(	PUNCT
admet-648	163	8	2010	2010	NUM
admet-648	163	9	)	)	PUNCT
admet-648	163	10	932	932	NUM
admet-648	163	11	-	-	SYM
admet-648	163	12	941	941	NUM
admet-648	163	13	.	.	PUNCT
admet-648	164	1	[	[	X
admet-648	164	2	2	2	X
admet-648	164	3	]	]	PUNCT
admet-648	164	4	e.	e.	PROPN
admet-648	164	5	stein	stein	PROPN
admet-648	164	6	,	,	PUNCT
admet-648	164	7	k.	k.	PROPN
admet-648	164	8	yen	yen	PROPN
admet-648	164	9	.	.	PUNCT
admet-648	165	1	targeted	target	VERB
admet-648	165	2	differentiation	differentiation	NOUN
admet-648	165	3	therapy	therapy	NOUN
admet-648	165	4	with	with	ADP
admet-648	165	5	mutant	mutant	ADJ
admet-648	165	6	idh	idh	NOUN
admet-648	165	7	inhibitors	inhibitor	NOUN
admet-648	165	8	:	:	PUNCT
admet-648	165	9	early	early	ADJ
admet-648	165	10	experiences	experience	NOUN
admet-648	165	11	and	and	CCONJ
admet-648	165	12	parallels	parallel	NOUN
admet-648	165	13	with	with	ADP
admet-648	165	14	other	other	ADJ
admet-648	165	15	differentiation	differentiation	NOUN
admet-648	165	16	agents	agent	NOUN
admet-648	165	17	.	.	PUNCT
admet-648	166	1	annual	annual	ADJ
admet-648	166	2	reviews	review	NOUN
admet-648	166	3	in	in	ADP
admet-648	166	4	cancer	cancer	NOUN
admet-648	166	5	biology	biology	NOUN
admet-648	166	6	1	1	NUM
admet-648	166	7	(	(	PUNCT
admet-648	166	8	2017	2017	NUM
admet-648	166	9	)	)	PUNCT
admet-648	166	10	379401	379401	NUM
admet-648	166	11	.	.	PUNCT
admet-648	167	1	[	[	X
admet-648	167	2	3	3	NUM
admet-648	167	3	]	]	X
admet-648	167	4	m.j	m.j	PROPN
admet-648	167	5	.	.	PROPN
admet-648	167	6	buege	buege	PROPN
admet-648	167	7	,	,	PUNCT
admet-648	167	8	a.j	a.j	PROPN
admet-648	167	9	.	.	PROPN
admet-648	167	10	dipippo	dipippo	PROPN
admet-648	167	11	,	,	PUNCT
admet-648	167	12	c.d	c.d	PROPN
admet-648	167	13	.	.	PROPN
admet-648	167	14	dinardo	dinardo	PROPN
admet-648	167	15	.	.	PUNCT
admet-648	168	1	evolving	evolve	VERB
admet-648	168	2	treatment	treatment	NOUN
admet-648	168	3	strategies	strategy	NOUN
admet-648	168	4	for	for	ADP
admet-648	168	5	elder	elder	ADJ
admet-648	168	6	leukemia	leukemia	NOUN
admet-648	168	7	patients	patient	NOUN
admet-648	168	8	with	with	ADP
admet-648	168	9	idh	idh	NOUN
admet-648	168	10	mutations	mutation	NOUN
admet-648	168	11	.	.	PUNCT
admet-648	169	1	cancers	cancer	NOUN
admet-648	169	2	10	10	NUM
admet-648	169	3	(	(	PUNCT
admet-648	169	4	2018	2018	NUM
admet-648	169	5	)	)	PUNCT
admet-648	169	6	e187	e187	NUM
admet-648	169	7	.	.	PUNCT
admet-648	170	1	[	[	X
admet-648	170	2	4	4	X
admet-648	170	3	]	]	PUNCT
admet-648	170	4	j.	j.	PROPN
admet-648	170	5	popovici	popovici	PROPN
admet-648	170	6	-	-	PUNCT
admet-648	170	7	muller	muller	NOUN
admet-648	170	8	,	,	PUNCT
admet-648	170	9	r.m	r.m	PROPN
admet-648	170	10	.	.	PROPN
admet-648	170	11	lemieux	lemieux	PROPN
admet-648	170	12	,	,	PUNCT
admet-648	170	13	e.	e.	PROPN
admet-648	170	14	artin	artin	PROPN
admet-648	170	15	,	,	PUNCT
admet-648	170	16	j.o	j.o	PROPN
admet-648	170	17	.	.	PROPN
admet-648	170	18	saunders	saunders	PROPN
admet-648	170	19	,	,	PUNCT
admet-648	170	20	f.g	f.g	PROPN
admet-648	170	21	.	.	PROPN
admet-648	170	22	salituro	salituro	PROPN
admet-648	170	23	,	,	PUNCT
admet-648	170	24	j.	j.	PROPN
admet-648	170	25	travins	travins	PROPN
admet-648	170	26	et	et	PROPN
admet-648	170	27	al	al	PROPN
admet-648	170	28	.	.	PROPN
admet-648	170	29	discovery	discovery	PROPN
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admet-648	170	31	ag-120	ag-120	PROPN
admet-648	170	32	(	(	PUNCT
admet-648	170	33	ivosidenib	ivosidenib	NOUN
admet-648	170	34	):	):	PUNCT
admet-648	170	35	a	a	DET
admet-648	170	36	first	first	ADJ
admet-648	170	37	-	-	PUNCT
admet-648	170	38	in	in	ADP
admet-648	170	39	-	-	PUNCT
admet-648	170	40	class	class	NOUN
admet-648	170	41	mutant	mutant	NOUN
admet-648	170	42	idh1	idh1	NOUN
admet-648	170	43	inhibitor	inhibitor	NOUN
admet-648	170	44	for	for	ADP
admet-648	170	45	the	the	DET
admet-648	170	46	treatment	treatment	NOUN
admet-648	170	47	of	of	ADP
admet-648	170	48	idh1	idh1	NOUN
admet-648	170	49	mutant	mutant	ADJ
admet-648	170	50	cancers	cancer	NOUN
admet-648	170	51	.	.	PUNCT
admet-648	171	1	acs	acs	PROPN
admet-648	171	2	medicinal	medicinal	ADJ
admet-648	171	3	chemistry	chemistry	NOUN
admet-648	171	4	letters	letter	NOUN
admet-648	171	5	9	9	NUM
admet-648	171	6	(	(	PUNCT
admet-648	171	7	2018	2018	NUM
admet-648	171	8	)	)	PUNCT
admet-648	171	9	300	300	NUM
admet-648	171	10	-	-	SYM
admet-648	171	11	305	305	NUM
admet-648	171	12	.	.	PUNCT
admet-648	172	1	[	[	X
admet-648	172	2	5	5	NUM
admet-648	172	3	]	]	X
admet-648	172	4	tibsovo	tibsovo	PROPN
admet-648	172	5	(	(	PUNCT
admet-648	172	6	ivosidenib	ivosidenib	PROPN
admet-648	172	7	)	)	PUNCT
admet-648	172	8	prescribing	prescribing	NOUN
admet-648	172	9	information	information	NOUN
admet-648	172	10	,	,	PUNCT
admet-648	172	11	agios	agios	PROPN
admet-648	172	12	pharmaceuticals	pharmaceutical	NOUN
admet-648	172	13	,	,	PUNCT
admet-648	172	14	inc	inc	PROPN
admet-648	172	15	,	,	PUNCT
admet-648	172	16	july	july	PROPN
admet-648	172	17	2018	2018	NUM
admet-648	172	18	.	.	PUNCT
admet-648	173	1	available	available	ADJ
admet-648	173	2	at	at	ADP
admet-648	173	3	www.accessdata.fda.gov	www.accessdata.fda.gov	PROPN
admet-648	173	4	.	.	PUNCT
admet-648	174	1	accessed	access	VERB
admet-648	174	2	november	november	PROPN
admet-648	174	3	9	9	NUM
admet-648	174	4	,	,	PUNCT
admet-648	174	5	2018	2018	NUM
admet-648	174	6	.	.	PUNCT
admet-648	175	1	[	[	X
admet-648	175	2	6	6	NUM
admet-648	175	3	]	]	PUNCT
admet-648	175	4	us	us	PROPN
admet-648	175	5	dhhs	dhhs	PROPN
admet-648	175	6	,	,	PUNCT
admet-648	175	7	fda	fda	PROPN
admet-648	175	8	,	,	PUNCT
admet-648	175	9	cder	cder	NOUN
admet-648	175	10	,	,	PUNCT
admet-648	175	11	cvm	cvm	PROPN
admet-648	175	12	.	.	PUNCT
admet-648	175	13	guidance	guidance	NOUN
admet-648	175	14	for	for	ADP
admet-648	175	15	industry	industry	NOUN
admet-648	175	16	:	:	PUNCT
admet-648	175	17	bioanalytical	bioanalytical	ADJ
admet-648	175	18	method	method	NOUN
admet-648	175	19	validation	validation	NOUN
admet-648	175	20	.	.	PUNCT
admet-648	176	1	u.s	u.s	PROPN
admet-648	176	2	.	.	PROPN
admet-648	176	3	department	department	PROPN
admet-648	176	4	of	of	ADP
admet-648	176	5	health	health	PROPN
admet-648	176	6	and	and	CCONJ
admet-648	176	7	human	human	ADJ
admet-648	176	8	services	service	NOUN
admet-648	176	9	,	,	PUNCT
admet-648	176	10	food	food	NOUN
admet-648	176	11	and	and	CCONJ
admet-648	176	12	drug	drug	NOUN
admet-648	176	13	administration	administration	NOUN
admet-648	176	14	,	,	PUNCT
admet-648	176	15	center	center	NOUN
admet-648	176	16	for	for	ADP
admet-648	176	17	drug	drug	NOUN
admet-648	176	18	evaluation	evaluation	NOUN
admet-648	176	19	and	and	CCONJ
admet-648	176	20	research	research	NOUN
admet-648	176	21	(	(	PUNCT
admet-648	176	22	cder	cder	NOUN
admet-648	176	23	)	)	PUNCT
admet-648	176	24	,	,	PUNCT
admet-648	176	25	center	center	NOUN
admet-648	176	26	for	for	ADP
admet-648	176	27	veterinary	veterinary	ADJ
admet-648	176	28	medicine	medicine	NOUN
admet-648	176	29	(	(	PUNCT
admet-648	176	30	cvm	cvm	PROPN
admet-648	176	31	)	)	PUNCT
admet-648	176	32	,	,	PUNCT
admet-648	176	33	(	(	PUNCT
admet-648	176	34	2018	2018	NUM
admet-648	176	35	)	)	PUNCT
admet-648	176	36	,	,	PUNCT
admet-648	176	37	rockville	rockville	PROPN
admet-648	176	38	,	,	PUNCT
admet-648	176	39	md	md	PROPN
admet-648	176	40	,	,	PUNCT
admet-648	176	41	usa	usa	PROPN
admet-648	176	42	.	.	PUNCT
admet-648	177	1	©	©	PROPN
admet-648	177	2	2019	2019	NUM
admet-648	177	3	by	by	ADP
admet-648	177	4	the	the	DET
admet-648	177	5	authors	author	NOUN
admet-648	177	6	;	;	PUNCT
admet-648	177	7	licensee	licensee	PROPN
admet-648	177	8	iapc	iapc	PROPN
admet-648	177	9	,	,	PUNCT
admet-648	177	10	zagreb	zagreb	PROPN
admet-648	177	11	,	,	PUNCT
admet-648	177	12	croatia	croatia	PROPN
admet-648	177	13	.	.	PUNCT
admet-648	178	1	this	this	DET
admet-648	178	2	article	article	NOUN
admet-648	178	3	is	be	AUX
admet-648	178	4	an	an	DET
admet-648	178	5	open	open	ADJ
admet-648	178	6	-	-	PUNCT
admet-648	178	7	access	access	NOUN
admet-648	178	8	article	article	NOUN
admet-648	178	9	distributed	distribute	VERB
admet-648	178	10	under	under	ADP
admet-648	178	11	the	the	DET
admet-648	178	12	terms	term	NOUN
admet-648	178	13	and	and	CCONJ
admet-648	178	14	conditions	condition	NOUN
admet-648	178	15	of	of	ADP
admet-648	178	16	the	the	DET
admet-648	178	17	creative	creative	ADJ
admet-648	178	18	commons	common	NOUN
admet-648	178	19	attribution	attribution	NOUN
admet-648	178	20	license	license	NOUN
admet-648	178	21	(	(	PUNCT
admet-648	178	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-648	178	23	)	)	PUNCT
admet-648	178	24	http://www.accessdata.fda.gov/	http://www.accessdata.fda.gov/	PROPN
admet-648	179	1	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN