id	sid	tid	token	lemma	pos
admet-657	1	1	permeation	permeation	NOUN
admet-657	1	2	characteristics	characteristic	NOUN
admet-657	1	3	of	of	ADP
admet-657	1	4	tetracyclines	tetracycline	NOUN
admet-657	1	5	in	in	ADP
admet-657	1	6	parallel	parallel	ADJ
admet-657	1	7	artificial	artificial	ADJ
admet-657	1	8	membrane	membrane	NOUN
admet-657	1	9	permeation	permeation	NOUN
admet-657	1	10	assay	assay	PROPN
admet-657	1	11	doi	doi	PROPN
admet-657	1	12	:	:	PUNCT
admet-657	1	13	10.5599	10.5599	NUM
admet-657	1	14	/	/	SYM
admet-657	1	15	admet.657	admet.657	PROPN
admet-657	1	16	151	151	NUM
admet-657	1	17	admet	admet	X
admet-657	1	18	&	&	CCONJ
admet-657	1	19	dmpk	dmpk	PROPN
admet-657	1	20	7(3	7(3	NUM
admet-657	1	21	)	)	PUNCT
admet-657	1	22	(	(	PUNCT
admet-657	1	23	2019	2019	NUM
admet-657	1	24	)	)	PUNCT
admet-657	1	25	151	151	NUM
admet-657	1	26	-	-	SYM
admet-657	1	27	160	160	NUM
admet-657	1	28	;	;	PUNCT
admet-657	1	29	doi	doi	NOUN
admet-657	1	30	:	:	PUNCT
admet-657	1	31	http://dx.doi.org/10.5599/admet.657	http://dx.doi.org/10.5599/admet.657	X
admet-657	1	32	open	open	ADJ
admet-657	1	33	access	access	NOUN
admet-657	1	34	:	:	PUNCT
admet-657	1	35	issn	issn	PROPN
admet-657	1	36	:	:	PUNCT
admet-657	1	37	1848	1848	NUM
admet-657	1	38	-	-	SYM
admet-657	1	39	7718	7718	NUM
admet-657	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-657	1	41	original	original	ADJ
admet-657	1	42	scientific	scientific	ADJ
admet-657	1	43	paper	paper	NOUN
admet-657	1	44	permeation	permeation	NOUN
admet-657	1	45	characteristics	characteristic	NOUN
admet-657	1	46	of	of	ADP
admet-657	1	47	tetracyclines	tetracycline	NOUN
admet-657	1	48	in	in	ADP
admet-657	1	49	parallel	parallel	ADJ
admet-657	1	50	artificial	artificial	ADJ
admet-657	1	51	membrane	membrane	NOUN
admet-657	1	52	permeation	permeation	NOUN
admet-657	1	53	assay	assay	PROPN
admet-657	1	54	sachika	sachika	PROPN
admet-657	1	55	yamauchi	yamauchi	PROPN
admet-657	1	56	,	,	PUNCT
admet-657	1	57	kiyohiko	kiyohiko	VERB
admet-657	1	58	sugano	sugano	VERB
admet-657	1	59	molecular	molecular	ADJ
admet-657	1	60	pharmaceutics	pharmaceutic	NOUN
admet-657	1	61	lab	lab	NOUN
admet-657	1	62	.	.	PUNCT
admet-657	1	63	,	,	PUNCT
admet-657	1	64	college	college	NOUN
admet-657	1	65	of	of	ADP
admet-657	1	66	pharmaceutical	pharmaceutical	NOUN
admet-657	1	67	sciences	science	NOUN
admet-657	1	68	,	,	PUNCT
admet-657	1	69	ritsumeikan	ritsumeikan	ADJ
admet-657	1	70	university	university	NOUN
admet-657	1	71	,	,	PUNCT
admet-657	1	72	1	1	NUM
admet-657	1	73	-	-	SYM
admet-657	1	74	1	1	NUM
admet-657	1	75	-	-	SYM
admet-657	1	76	1	1	NUM
admet-657	1	77	,	,	PUNCT
admet-657	1	78	noji	noji	NOUN
admet-657	1	79	-	-	PUNCT
admet-657	1	80	higashi	higashi	PROPN
admet-657	1	81	,	,	PUNCT
admet-657	1	82	kusatsu	kusatsu	NOUN
admet-657	1	83	,	,	PUNCT
admet-657	1	84	shiga	shiga	NOUN
admet-657	1	85	525	525	NUM
admet-657	1	86	-	-	SYM
admet-657	1	87	8577	8577	NUM
admet-657	1	88	,	,	PUNCT
admet-657	1	89	japan	japan	PROPN
admet-657	1	90	*	*	PUNCT
admet-657	1	91	corresponding	correspond	VERB
admet-657	1	92	author	author	NOUN
admet-657	1	93	:	:	PUNCT
admet-657	1	94	e	e	NOUN
admet-657	1	95	-	-	NOUN
admet-657	1	96	mail	mail	NOUN
admet-657	1	97	:	:	PUNCT
admet-657	1	98	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-657	1	99	;	;	PUNCT
admet-657	1	100	tel	tel	PROPN
admet-657	1	101	.	.	PROPN
admet-657	1	102	:	:	PUNCT
admet-657	2	1	+81	+81	PROPN
admet-657	2	2	-	-	PUNCT
admet-657	2	3	77	77	NUM
admet-657	2	4	-	-	PUNCT
admet-657	2	5	561	561	NUM
admet-657	2	6	-	-	PUNCT
admet-657	2	7	2773	2773	NUM
admet-657	2	8	received	receive	VERB
admet-657	2	9	:	:	PUNCT
admet-657	2	10	january	january	PROPN
admet-657	2	11	17	17	NUM
admet-657	2	12	,	,	PUNCT
admet-657	2	13	2019	2019	NUM
admet-657	2	14	;	;	PUNCT
admet-657	2	15	revised	revise	VERB
admet-657	2	16	:	:	PUNCT
admet-657	2	17	march	march	PROPN
admet-657	2	18	06	06	NUM
admet-657	2	19	,	,	PUNCT
admet-657	2	20	2019	2019	NUM
admet-657	2	21	;	;	PUNCT
admet-657	2	22	available	available	ADJ
admet-657	2	23	online	online	ADV
admet-657	2	24	:	:	PUNCT
admet-657	2	25	may	may	AUX
admet-657	2	26	8	8	NUM
admet-657	2	27	,	,	PUNCT
admet-657	2	28	2019	2019	NUM
admet-657	2	29	abstract	abstract	NOUN
admet-657	2	30	the	the	DET
admet-657	2	31	purpose	purpose	NOUN
admet-657	2	32	of	of	ADP
admet-657	2	33	the	the	DET
admet-657	2	34	present	present	ADJ
admet-657	2	35	study	study	NOUN
admet-657	2	36	was	be	AUX
admet-657	2	37	to	to	PART
admet-657	2	38	characterize	characterize	VERB
admet-657	2	39	the	the	DET
admet-657	2	40	passive	passive	ADJ
admet-657	2	41	permeation	permeation	NOUN
admet-657	2	42	of	of	ADP
admet-657	2	43	tetracyclines	tetracycline	NOUN
admet-657	2	44	in	in	ADP
admet-657	2	45	the	the	DET
admet-657	2	46	parallel	parallel	ADJ
admet-657	2	47	artificial	artificial	ADJ
admet-657	2	48	membrane	membrane	NOUN
admet-657	2	49	permeation	permeation	NOUN
admet-657	2	50	assay	assay	NOUN
admet-657	2	51	(	(	PUNCT
admet-657	2	52	pampa	pampa	PROPN
admet-657	2	53	)	)	PUNCT
admet-657	2	54	.	.	PUNCT
admet-657	3	1	tetracyclines	tetracycline	NOUN
admet-657	3	2	exist	exist	VERB
admet-657	3	3	as	as	ADP
admet-657	3	4	zwitterion	zwitterion	NOUN
admet-657	3	5	at	at	ADP
admet-657	3	6	physiological	physiological	ADJ
admet-657	3	7	ph	ph	NOUN
admet-657	3	8	.	.	PUNCT
admet-657	4	1	the	the	DET
admet-657	4	2	pampa	pampa	PROPN
admet-657	4	3	membrane	membrane	NOUN
admet-657	4	4	was	be	AUX
admet-657	4	5	prepared	prepare	VERB
admet-657	4	6	by	by	ADP
admet-657	4	7	impregnating	impregnate	VERB
admet-657	4	8	a	a	DET
admet-657	4	9	phospholipid	phospholipid	NOUN
admet-657	4	10	/	/	SYM
admet-657	4	11	decane	decane	NOUN
admet-657	4	12	solution	solution	NOUN
admet-657	4	13	to	to	ADP
admet-657	4	14	a	a	DET
admet-657	4	15	filter	filter	NOUN
admet-657	4	16	support	support	NOUN
admet-657	4	17	.	.	PUNCT
admet-657	5	1	the	the	DET
admet-657	5	2	permeation	permeation	NOUN
admet-657	5	3	coefficient	coefficient	NOUN
admet-657	5	4	(	(	PUNCT
admet-657	5	5	pe	pe	INTJ
admet-657	5	6	)	)	PUNCT
admet-657	5	7	of	of	ADP
admet-657	5	8	tetracycline	tetracycline	PROPN
admet-657	5	9	(	(	PUNCT
admet-657	5	10	tc	tc	NOUN
admet-657	5	11	)	)	PUNCT
admet-657	5	12	was	be	AUX
admet-657	5	13	markedly	markedly	ADV
admet-657	5	14	affected	affect	VERB
admet-657	5	15	by	by	ADP
admet-657	5	16	the	the	DET
admet-657	5	17	lipid	lipid	NOUN
admet-657	5	18	composition	composition	NOUN
admet-657	5	19	of	of	ADP
admet-657	5	20	the	the	DET
admet-657	5	21	pampa	pampa	NOUN
admet-657	5	22	membrane	membrane	NOUN
admet-657	5	23	.	.	PUNCT
admet-657	6	1	no	no	DET
admet-657	6	2	permeation	permeation	NOUN
admet-657	6	3	was	be	AUX
admet-657	6	4	observed	observe	VERB
admet-657	6	5	when	when	SCONJ
admet-657	6	6	phospholipid	phospholipid	NOUN
admet-657	6	7	was	be	AUX
admet-657	6	8	not	not	PART
admet-657	6	9	added	add	VERB
admet-657	6	10	(	(	PUNCT
admet-657	6	11	pure	pure	ADJ
admet-657	6	12	decane	decane	NOUN
admet-657	6	13	membrane	membrane	NOUN
admet-657	6	14	,	,	PUNCT
admet-657	6	15	pe	pe	X
admet-657	6	16	<	<	X
admet-657	6	17	0.05	0.05	NUM
admet-657	6	18	×	×	NOUN
admet-657	6	19	10	10	NUM
admet-657	6	20	-6	-6	NOUN
admet-657	6	21	cm	cm	PROPN
admet-657	6	22	/	/	SYM
admet-657	6	23	sec	sec	PROPN
admet-657	6	24	)	)	PUNCT
admet-657	6	25	.	.	PUNCT
admet-657	7	1	with	with	ADP
admet-657	7	2	the	the	DET
admet-657	7	3	addition	addition	NOUN
admet-657	7	4	of	of	ADP
admet-657	7	5	2	2	NUM
admet-657	7	6	%	%	NOUN
admet-657	7	7	pc	pc	NOUN
admet-657	7	8	,	,	PUNCT
admet-657	7	9	little	little	ADJ
admet-657	7	10	or	or	CCONJ
admet-657	7	11	no	no	PRON
admet-657	7	12	increase	increase	NOUN
admet-657	7	13	in	in	ADP
admet-657	7	14	pe	pe	PROPN
admet-657	7	15	was	be	AUX
admet-657	7	16	observed	observe	VERB
admet-657	7	17	.	.	PUNCT
admet-657	8	1	the	the	DET
admet-657	8	2	addition	addition	NOUN
admet-657	8	3	of	of	ADP
admet-657	8	4	1	1	NUM
admet-657	8	5	%	%	NOUN
admet-657	8	6	pe	pe	PROPN
admet-657	8	7	increased	increase	VERB
admet-657	8	8	the	the	DET
admet-657	8	9	pe	pe	PROPN
admet-657	8	10	value	value	NOUN
admet-657	8	11	more	more	ADV
admet-657	8	12	than	than	ADP
admet-657	8	13	tenfold	tenfold	ADV
admet-657	8	14	.	.	PUNCT
admet-657	9	1	the	the	DET
admet-657	9	2	addition	addition	NOUN
admet-657	9	3	of	of	ADP
admet-657	9	4	2	2	NUM
admet-657	9	5	%	%	NOUN
admet-657	9	6	soybean	soybean	NOUN
admet-657	9	7	lecithin	lecithin	NOUN
admet-657	9	8	containing	contain	VERB
admet-657	9	9	phosphatidylinositol	phosphatidylinositol	NOUN
admet-657	9	10	(	(	PUNCT
admet-657	9	11	pi	pi	NOUN
admet-657	9	12	)	)	PUNCT
admet-657	9	13	and	and	CCONJ
admet-657	9	14	phosphatidic	phosphatidic	ADJ
admet-657	9	15	acid	acid	NOUN
admet-657	9	16	(	(	PUNCT
admet-657	9	17	pa	pa	PROPN
admet-657	9	18	)	)	PUNCT
admet-657	9	19	increased	increase	VERB
admet-657	9	20	the	the	DET
admet-657	9	21	pe	pe	PROPN
admet-657	9	22	value	value	NOUN
admet-657	9	23	to	to	ADP
admet-657	9	24	above	above	ADP
admet-657	9	25	4	4	NUM
admet-657	9	26	×	×	NOUN
admet-657	9	27	10	10	NUM
admet-657	9	28	-6	-6	NOUN
admet-657	9	29	cm	cm	PROPN
admet-657	9	30	/	/	SYM
admet-657	9	31	sec	sec	PROPN
admet-657	9	32	.	.	PUNCT
admet-657	10	1	the	the	DET
admet-657	10	2	pe	pe	PROPN
admet-657	10	3	value	value	NOUN
admet-657	10	4	was	be	AUX
admet-657	10	5	further	far	ADV
admet-657	10	6	increased	increase	VERB
admet-657	10	7	to	to	ADP
admet-657	10	8	15	15	NUM
admet-657	10	9	×	×	NOUN
admet-657	10	10	10	10	NUM
admet-657	10	11	-6	-6	NOUN
admet-657	10	12	cm	cm	NOUN
admet-657	10	13	/	/	SYM
admet-657	10	14	sec	sec	PROPN
admet-657	10	15	by	by	ADP
admet-657	10	16	increasing	increase	VERB
admet-657	10	17	the	the	DET
admet-657	10	18	concentration	concentration	NOUN
admet-657	10	19	of	of	ADP
admet-657	10	20	soybean	soybean	NOUN
admet-657	10	21	lecithin	lecithin	NOUN
admet-657	10	22	from	from	ADP
admet-657	10	23	2	2	NUM
admet-657	10	24	to	to	PART
admet-657	10	25	10	10	NUM
admet-657	10	26	%	%	NOUN
admet-657	10	27	.	.	PUNCT
admet-657	11	1	the	the	DET
admet-657	11	2	pe	pe	PROPN
admet-657	11	3	value	value	NOUN
admet-657	11	4	showed	show	VERB
admet-657	11	5	ph	ph	ADJ
admet-657	11	6	and	and	CCONJ
admet-657	11	7	temperature	temperature	NOUN
admet-657	11	8	dependence	dependence	NOUN
admet-657	11	9	,	,	PUNCT
admet-657	11	10	whereas	whereas	SCONJ
admet-657	11	11	it	it	PRON
admet-657	11	12	was	be	AUX
admet-657	11	13	not	not	PART
admet-657	11	14	affected	affect	VERB
admet-657	11	15	by	by	ADP
admet-657	11	16	the	the	DET
admet-657	11	17	ionic	ionic	ADJ
admet-657	11	18	strength	strength	NOUN
admet-657	11	19	,	,	PUNCT
admet-657	11	20	tc	tc	NOUN
admet-657	11	21	concentration	concentration	NOUN
admet-657	11	22	,	,	PUNCT
admet-657	11	23	and	and	CCONJ
admet-657	11	24	ion	ion	NOUN
admet-657	11	25	-	-	PUNCT
admet-657	11	26	pair	pair	NOUN
admet-657	11	27	transport	transport	NOUN
admet-657	11	28	inhibitors	inhibitor	NOUN
admet-657	11	29	.	.	PUNCT
admet-657	12	1	a	a	DET
admet-657	12	2	weak	weak	ADJ
admet-657	12	3	correlation	correlation	NOUN
admet-657	12	4	was	be	AUX
admet-657	12	5	observed	observe	VERB
admet-657	12	6	between	between	ADP
admet-657	12	7	the	the	DET
admet-657	12	8	pe	pe	PROPN
admet-657	12	9	values	value	NOUN
admet-657	12	10	and	and	CCONJ
admet-657	12	11	octanol	octanol	NOUN
admet-657	12	12	-	-	PUNCT
admet-657	12	13	buffer	buffer	NOUN
admet-657	12	14	distribution	distribution	NOUN
admet-657	12	15	coefficients	coefficient	NOUN
admet-657	12	16	of	of	ADP
admet-657	12	17	tetracyclines	tetracyclines	PROPN
admet-657	12	18	.	.	PUNCT
admet-657	13	1	these	these	DET
admet-657	13	2	results	result	NOUN
admet-657	13	3	suggest	suggest	VERB
admet-657	13	4	that	that	SCONJ
admet-657	13	5	inter	inter	ADJ
admet-657	13	6	-	-	ADJ
admet-657	13	7	molecular	molecular	ADJ
admet-657	13	8	interactions	interaction	NOUN
admet-657	13	9	between	between	ADP
admet-657	13	10	tc	tc	NOUN
admet-657	13	11	and	and	CCONJ
admet-657	13	12	pe	pe	INTJ
admet-657	13	13	,	,	PUNCT
admet-657	13	14	pi	pi	NOUN
admet-657	13	15	and/or	and/or	CCONJ
admet-657	13	16	pa	pa	PROPN
admet-657	13	17	facilitate	facilitate	VERB
admet-657	13	18	the	the	DET
admet-657	13	19	passive	passive	ADJ
admet-657	13	20	diffusion	diffusion	NOUN
admet-657	13	21	of	of	ADP
admet-657	13	22	tc	tc	NOUN
admet-657	13	23	across	across	ADP
admet-657	13	24	the	the	DET
admet-657	13	25	pampa	pampa	NOUN
admet-657	13	26	membrane	membrane	NOUN
admet-657	13	27	.	.	PUNCT
admet-657	14	1	keywords	keyword	NOUN
admet-657	14	2	zwitterion	zwitterion	NOUN
admet-657	14	3	;	;	PUNCT
admet-657	14	4	artificial	artificial	ADJ
admet-657	14	5	membrane	membrane	NOUN
admet-657	14	6	;	;	PUNCT
admet-657	14	7	permeability	permeability	NOUN
admet-657	14	8	;	;	PUNCT
admet-657	14	9	phospholipid	phospholipid	NOUN
admet-657	14	10	introduction	introduction	NOUN
admet-657	14	11	zwitterionic	zwitterionic	ADJ
admet-657	14	12	drugs	drug	NOUN
admet-657	14	13	are	be	AUX
admet-657	14	14	an	an	DET
admet-657	14	15	important	important	ADJ
admet-657	14	16	chemical	chemical	NOUN
admet-657	14	17	class	class	NOUN
admet-657	14	18	as	as	SCONJ
admet-657	14	19	they	they	PRON
admet-657	14	20	exhibit	exhibit	VERB
admet-657	14	21	unique	unique	ADJ
admet-657	14	22	physicochemical	physicochemical	ADJ
admet-657	14	23	and	and	CCONJ
admet-657	14	24	pharmacokinetic	pharmacokinetic	ADJ
admet-657	14	25	properties	property	NOUN
admet-657	14	26	[	[	X
admet-657	14	27	1	1	NUM
admet-657	14	28	,	,	PUNCT
admet-657	14	29	2	2	NUM
admet-657	14	30	]	]	PUNCT
admet-657	14	31	.	.	PUNCT
admet-657	15	1	a	a	DET
admet-657	15	2	zwitterionic	zwitterionic	ADJ
admet-657	15	3	drug	drug	NOUN
admet-657	15	4	possesses	possesse	NOUN
admet-657	15	5	at	at	ADV
admet-657	15	6	least	least	ADV
admet-657	15	7	one	one	NUM
admet-657	15	8	acidic	acidic	ADJ
admet-657	15	9	group	group	NOUN
admet-657	15	10	and	and	CCONJ
admet-657	15	11	at	at	ADV
admet-657	15	12	least	least	ADV
admet-657	15	13	one	one	NUM
admet-657	15	14	basic	basic	ADJ
admet-657	15	15	group	group	NOUN
admet-657	15	16	(	(	PUNCT
admet-657	15	17	acidic	acidic	PROPN
admet-657	15	18	pka	pka	PROPN
admet-657	15	19	<	<	X
admet-657	15	20	basic	basic	ADJ
admet-657	15	21	pka	pka	PROPN
admet-657	15	22	)	)	PUNCT
admet-657	15	23	.	.	PUNCT
admet-657	16	1	typical	typical	ADJ
admet-657	16	2	examples	example	NOUN
admet-657	16	3	of	of	ADP
admet-657	16	4	zwitterionic	zwitterionic	ADJ
admet-657	16	5	drugs	drug	NOUN
admet-657	16	6	are	be	AUX
admet-657	16	7	antibacterials	antibacterial	NOUN
admet-657	16	8	,	,	PUNCT
admet-657	16	9	antiallergics	antiallergic	NOUN
admet-657	16	10	,	,	PUNCT
admet-657	16	11	and	and	CCONJ
admet-657	16	12	diuretics	diuretic	NOUN
admet-657	16	13	.	.	PUNCT
admet-657	17	1	zwitterion	zwitterion	NOUN
admet-657	17	2	drugs	drug	NOUN
admet-657	17	3	are	be	AUX
admet-657	17	4	less	less	ADV
admet-657	17	5	liable	liable	ADJ
admet-657	17	6	to	to	ADP
admet-657	17	7	human	human	ADJ
admet-657	17	8	ether	ether	NOUN
admet-657	17	9	-	-	PUNCT
admet-657	17	10	a	a	DET
admet-657	17	11	-	-	PUNCT
admet-657	17	12	go	go	NOUN
admet-657	17	13	-	-	PUNCT
admet-657	17	14	go	go	NOUN
admet-657	17	15	related	related	ADJ
admet-657	17	16	gene	gene	NOUN
admet-657	17	17	(	(	PUNCT
admet-657	17	18	herg	herg	PROPN
admet-657	17	19	)	)	PUNCT
admet-657	17	20	and	and	CCONJ
admet-657	17	21	phospholipidosis	phospholipidosis	NOUN
admet-657	17	22	compared	compare	VERB
admet-657	17	23	to	to	ADP
admet-657	17	24	hydrophobic	hydrophobic	NOUN
admet-657	17	25	bases	basis	NOUN
admet-657	17	26	[	[	X
admet-657	17	27	3	3	NUM
admet-657	17	28	,	,	PUNCT
admet-657	17	29	4	4	NUM
admet-657	17	30	]	]	PUNCT
admet-657	17	31	.	.	PUNCT
admet-657	18	1	according	accord	VERB
admet-657	18	2	to	to	ADP
admet-657	18	3	the	the	DET
admet-657	18	4	ph	ph	ADJ
admet-657	18	5	-	-	PUNCT
admet-657	18	6	partition	partition	NOUN
admet-657	18	7	theory	theory	NOUN
admet-657	18	8	,	,	PUNCT
admet-657	18	9	the	the	DET
admet-657	18	10	passive	passive	ADJ
admet-657	18	11	lipid	lipid	NOUN
admet-657	18	12	bilayer	bilayer	NOUN
admet-657	18	13	permeation	permeation	NOUN
admet-657	18	14	of	of	ADP
admet-657	18	15	a	a	DET
admet-657	18	16	zwitterionic	zwitterionic	ADJ
admet-657	18	17	drug	drug	NOUN
admet-657	18	18	is	be	AUX
admet-657	18	19	expected	expect	VERB
admet-657	18	20	to	to	PART
admet-657	18	21	be	be	AUX
admet-657	18	22	negligible	negligible	ADJ
admet-657	18	23	.	.	PUNCT
admet-657	19	1	however	however	ADV
admet-657	19	2	,	,	PUNCT
admet-657	19	3	many	many	ADJ
admet-657	19	4	zwitterionic	zwitterionic	ADJ
admet-657	19	5	drugs	drug	NOUN
admet-657	19	6	such	such	ADJ
admet-657	19	7	as	as	ADP
admet-657	19	8	tetracyclines	tetracycline	NOUN
admet-657	19	9	and	and	CCONJ
admet-657	19	10	fluoroquinolones	fluoroquinolone	NOUN
admet-657	19	11	show	show	VERB
admet-657	19	12	moderate	moderate	ADJ
admet-657	19	13	to	to	PART
admet-657	19	14	high	high	ADJ
admet-657	19	15	passive	passive	ADJ
admet-657	19	16	permeability	permeability	NOUN
admet-657	19	17	in	in	ADP
admet-657	19	18	vitro	vitro	X
admet-657	19	19	[	[	X
admet-657	19	20	5	5	NUM
admet-657	19	21	]	]	PUNCT
admet-657	19	22	and	and	CCONJ
admet-657	19	23	good	good	ADJ
admet-657	19	24	bioavailability	bioavailability	NOUN
admet-657	19	25	in	in	ADP
admet-657	19	26	vivo	vivo	NOUN
admet-657	19	27	[	[	X
admet-657	19	28	6	6	NUM
admet-657	19	29	]	]	PUNCT
admet-657	19	30	.	.	PUNCT
admet-657	20	1	the	the	DET
admet-657	20	2	parallel	parallel	ADJ
admet-657	20	3	artificial	artificial	ADJ
admet-657	20	4	membrane	membrane	NOUN
admet-657	20	5	permeation	permeation	NOUN
admet-657	20	6	assay	assay	NOUN
admet-657	20	7	(	(	PUNCT
admet-657	20	8	pampa	pampa	PROPN
admet-657	20	9	)	)	PUNCT
admet-657	20	10	has	have	AUX
admet-657	20	11	been	be	AUX
admet-657	20	12	widely	widely	ADV
admet-657	20	13	used	use	VERB
admet-657	20	14	as	as	ADP
admet-657	20	15	a	a	DET
admet-657	20	16	high	high	ADJ
admet-657	20	17	throughput	throughput	NOUN
admet-657	20	18	assay	assay	VERB
admet-657	20	19	for	for	ADP
admet-657	20	20	passive	passive	ADJ
admet-657	20	21	membrane	membrane	NOUN
admet-657	20	22	permeation	permeation	NOUN
admet-657	20	23	[	[	X
admet-657	20	24	7	7	NUM
admet-657	20	25	-	-	SYM
admet-657	20	26	10	10	NUM
admet-657	20	27	]	]	PUNCT
admet-657	20	28	.	.	PUNCT
admet-657	21	1	interestingly	interestingly	ADV
admet-657	21	2	,	,	PUNCT
admet-657	21	3	several	several	ADJ
admet-657	21	4	zwitterionic	zwitterionic	ADJ
admet-657	21	5	drugs	drug	NOUN
admet-657	21	6	showed	show	VERB
admet-657	21	7	moderate	moderate	ADJ
admet-657	21	8	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-657	21	9	yamauchi	yamauchi	PROPN
admet-657	21	10	and	and	CCONJ
admet-657	21	11	sugano	sugano	PROPN
admet-657	21	12	admet	admet	PROPN
admet-657	21	13	&	&	CCONJ
admet-657	21	14	dmpk	dmpk	PROPN
admet-657	21	15	7(3	7(3	NUM
admet-657	21	16	)	)	PUNCT
admet-657	21	17	(	(	PUNCT
admet-657	21	18	2019	2019	NUM
admet-657	21	19	)	)	PUNCT
admet-657	21	20	151	151	NUM
admet-657	21	21	-	-	SYM
admet-657	21	22	160	160	NUM
admet-657	21	23	152	152	NUM
admet-657	21	24	to	to	ADP
admet-657	21	25	high	high	ADJ
admet-657	21	26	permeability	permeability	NOUN
admet-657	21	27	in	in	ADP
admet-657	21	28	pampa	pampa	PROPN
admet-657	21	29	[	[	X
admet-657	21	30	6	6	NUM
admet-657	21	31	,	,	PUNCT
admet-657	21	32	11	11	NUM
admet-657	21	33	]	]	PUNCT
admet-657	21	34	.	.	PUNCT
admet-657	22	1	in	in	ADP
admet-657	22	2	the	the	DET
admet-657	22	3	case	case	NOUN
admet-657	22	4	of	of	ADP
admet-657	22	5	cationic	cationic	ADJ
admet-657	22	6	drugs	drug	NOUN
admet-657	22	7	,	,	PUNCT
admet-657	22	8	ion	ion	NOUN
admet-657	22	9	pair	pair	NOUN
admet-657	22	10	formation	formation	NOUN
admet-657	22	11	with	with	ADP
admet-657	22	12	an	an	DET
admet-657	22	13	anionic	anionic	ADJ
admet-657	22	14	phospholipid	phospholipid	NOUN
admet-657	22	15	enhances	enhance	VERB
admet-657	22	16	the	the	DET
admet-657	22	17	passive	passive	ADJ
admet-657	22	18	permeation	permeation	NOUN
admet-657	22	19	of	of	ADP
admet-657	22	20	a	a	DET
admet-657	22	21	drug	drug	NOUN
admet-657	22	22	[	[	X
admet-657	22	23	12,13	12,13	NUM
admet-657	22	24	]	]	PUNCT
admet-657	22	25	.	.	PUNCT
admet-657	23	1	however	however	ADV
admet-657	23	2	,	,	PUNCT
admet-657	23	3	the	the	DET
admet-657	23	4	permeation	permeation	NOUN
admet-657	23	5	mechanism	mechanism	NOUN
admet-657	23	6	of	of	ADP
admet-657	23	7	zwitterionic	zwitterionic	ADJ
admet-657	23	8	drugs	drug	NOUN
admet-657	23	9	has	have	AUX
admet-657	23	10	not	not	PART
admet-657	23	11	been	be	AUX
admet-657	23	12	investigated	investigate	VERB
admet-657	23	13	.	.	PUNCT
admet-657	24	1	the	the	DET
admet-657	24	2	purpose	purpose	NOUN
admet-657	24	3	of	of	ADP
admet-657	24	4	the	the	DET
admet-657	24	5	present	present	ADJ
admet-657	24	6	study	study	NOUN
admet-657	24	7	was	be	AUX
admet-657	24	8	to	to	PART
admet-657	24	9	characterize	characterize	VERB
admet-657	24	10	the	the	DET
admet-657	24	11	passive	passive	ADJ
admet-657	24	12	permeation	permeation	NOUN
admet-657	24	13	of	of	ADP
admet-657	24	14	zwitterion	zwitterion	NOUN
admet-657	24	15	drugs	drug	NOUN
admet-657	24	16	in	in	ADP
admet-657	24	17	pampa	pampa	PROPN
admet-657	24	18	.	.	PUNCT
admet-657	25	1	tetracyclines	tetracycline	NOUN
admet-657	25	2	were	be	AUX
admet-657	25	3	used	use	VERB
admet-657	25	4	as	as	ADP
admet-657	25	5	model	model	NOUN
admet-657	25	6	zwitterionic	zwitterionic	ADJ
admet-657	25	7	drugs	drug	NOUN
admet-657	25	8	in	in	ADP
admet-657	25	9	this	this	DET
admet-657	25	10	study	study	NOUN
admet-657	25	11	.	.	PUNCT
admet-657	26	1	tetracyclines	tetracycline	NOUN
admet-657	26	2	have	have	VERB
admet-657	26	3	three	three	NUM
admet-657	26	4	dissociative	dissociative	ADJ
admet-657	26	5	functional	functional	ADJ
admet-657	26	6	groups	group	NOUN
admet-657	26	7	(	(	PUNCT
admet-657	26	8	figure	figure	NOUN
admet-657	26	9	1	1	NUM
admet-657	26	10	)	)	PUNCT
admet-657	27	1	[	[	X
admet-657	27	2	14	14	NUM
admet-657	27	3	-	-	SYM
admet-657	27	4	16	16	NUM
admet-657	27	5	]	]	PUNCT
admet-657	27	6	.	.	PUNCT
admet-657	28	1	at	at	ADP
admet-657	28	2	the	the	DET
admet-657	28	3	physiological	physiological	ADJ
admet-657	28	4	ph	ph	NOUN
admet-657	28	5	in	in	ADP
admet-657	28	6	the	the	DET
admet-657	28	7	small	small	ADJ
admet-657	28	8	intestine	intestine	NOUN
admet-657	28	9	,	,	PUNCT
admet-657	28	10	they	they	PRON
admet-657	28	11	predominantly	predominantly	ADV
admet-657	28	12	exist	exist	VERB
admet-657	28	13	as	as	ADP
admet-657	28	14	zwitterion	zwitterion	NOUN
admet-657	28	15	[	[	X
admet-657	28	16	14	14	NUM
admet-657	28	17	]	]	PUNCT
admet-657	28	18	.	.	PUNCT
admet-657	29	1	the	the	DET
admet-657	29	2	octanol	octanol	NOUN
admet-657	29	3	buffer	buffer	NOUN
admet-657	29	4	partition	partition	NOUN
admet-657	29	5	coefficients	coefficient	NOUN
admet-657	29	6	(	(	PUNCT
admet-657	29	7	log	log	NOUN
admet-657	29	8	d	d	NOUN
admet-657	29	9	)	)	PUNCT
admet-657	29	10	of	of	ADP
admet-657	29	11	tetracyclines	tetracycline	NOUN
admet-657	29	12	are	be	AUX
admet-657	29	13	below	below	ADP
admet-657	29	14	0.2	0.2	NUM
admet-657	29	15	(	(	PUNCT
admet-657	29	16	table	table	NOUN
admet-657	29	17	1	1	NUM
admet-657	29	18	)	)	PUNCT
admet-657	30	1	[	[	X
admet-657	30	2	17	17	NUM
admet-657	30	3	]	]	PUNCT
admet-657	30	4	.	.	PUNCT
admet-657	31	1	in	in	ADP
admet-657	31	2	addition	addition	NOUN
admet-657	31	3	,	,	PUNCT
admet-657	31	4	they	they	PRON
admet-657	31	5	violate	violate	VERB
admet-657	31	6	the	the	DET
admet-657	31	7	lipinski	lipinski	PROPN
admet-657	31	8	’s	’s	PART
admet-657	31	9	rule	rule	NOUN
admet-657	31	10	of	of	ADP
admet-657	31	11	five	five	NUM
admet-657	31	12	in	in	ADP
admet-657	31	13	the	the	DET
admet-657	31	14	hydrogen	hydrogen	NOUN
admet-657	31	15	bond	bond	NOUN
admet-657	31	16	number	number	NOUN
admet-657	31	17	[	[	X
admet-657	31	18	18	18	NUM
admet-657	31	19	]	]	PUNCT
admet-657	31	20	.	.	PUNCT
admet-657	32	1	however	however	ADV
admet-657	32	2	,	,	PUNCT
admet-657	32	3	tetracyclines	tetracycline	NOUN
admet-657	32	4	show	show	VERB
admet-657	32	5	good	good	ADJ
admet-657	32	6	oral	oral	ADJ
admet-657	32	7	absorption	absorption	NOUN
admet-657	32	8	in	in	ADP
admet-657	32	9	vivo	vivo	NOUN
admet-657	32	10	[	[	X
admet-657	32	11	19	19	NUM
admet-657	32	12	]	]	PUNCT
admet-657	32	13	.	.	PUNCT
admet-657	33	1	interestingly	interestingly	ADV
admet-657	33	2	,	,	PUNCT
admet-657	33	3	tetracycline	tetracycline	PROPN
admet-657	33	4	showed	show	VERB
admet-657	33	5	moderate	moderate	ADJ
admet-657	33	6	permeability	permeability	NOUN
admet-657	33	7	in	in	ADP
admet-657	33	8	the	the	DET
admet-657	33	9	biomimetic	biomimetic	ADJ
admet-657	33	10	pampa	pampa	NOUN
admet-657	33	11	[	[	X
admet-657	33	12	9	9	NUM
admet-657	33	13	]	]	PUNCT
admet-657	33	14	.	.	PUNCT
admet-657	34	1	figure	figure	NOUN
admet-657	34	2	1	1	NUM
admet-657	34	3	.	.	PUNCT
admet-657	35	1	chemical	chemical	NOUN
admet-657	35	2	structures	structure	NOUN
admet-657	35	3	of	of	ADP
admet-657	35	4	tetracyclines	tetracycline	NOUN
admet-657	35	5	experimental	experimental	ADJ
admet-657	35	6	materials	material	NOUN
admet-657	35	7	tetracycline	tetracycline	VERB
admet-657	35	8	hydrochloride	hydrochloride	NOUN
admet-657	35	9	,	,	PUNCT
admet-657	35	10	l	l	NOUN
admet-657	35	11	-	-	NOUN
admet-657	35	12	leucine	leucine	NOUN
admet-657	35	13	,	,	PUNCT
admet-657	35	14	decane	decane	PROPN
admet-657	35	15	,	,	PUNCT
admet-657	35	16	sodium	sodium	NOUN
admet-657	35	17	dihydrogen	dihydrogen	NOUN
admet-657	35	18	phosphate	phosphate	NOUN
admet-657	35	19	,	,	PUNCT
admet-657	35	20	sodium	sodium	NOUN
admet-657	35	21	chloride	chloride	NOUN
admet-657	35	22	,	,	PUNCT
admet-657	35	23	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
admet-657	35	24	(	(	PUNCT
admet-657	35	25	pe	pe	NOUN
admet-657	35	26	)	)	PUNCT
admet-657	35	27	,	,	PUNCT
admet-657	35	28	and	and	CCONJ
admet-657	35	29	8n	8n	NOUN
admet-657	35	30	naoh	naoh	NOUN
admet-657	35	31	were	be	AUX
admet-657	35	32	purchased	purchase	VERB
admet-657	35	33	from	from	ADP
admet-657	35	34	wako	wako	PROPN
admet-657	35	35	pure	pure	ADJ
admet-657	35	36	chemical	chemical	NOUN
admet-657	35	37	industries	industry	NOUN
admet-657	35	38	,	,	PUNCT
admet-657	35	39	ltd	ltd	PROPN
admet-657	35	40	(	(	PUNCT
admet-657	35	41	osaka	osaka	PROPN
admet-657	35	42	,	,	PUNCT
admet-657	35	43	japan	japan	PROPN
admet-657	35	44	)	)	PUNCT
admet-657	35	45	.	.	PUNCT
admet-657	36	1	oxytetracycline	oxytetracycline	ADJ
admet-657	36	2	hydrochloride	hydrochloride	NOUN
admet-657	36	3	,	,	PUNCT
admet-657	36	4	minocycline	minocycline	ADJ
admet-657	36	5	hydrochloride	hydrochloride	NOUN
admet-657	36	6	,	,	PUNCT
admet-657	36	7	doxycycline	doxycycline	NOUN
admet-657	36	8	hyclate	hyclate	NOUN
admet-657	36	9	,	,	PUNCT
admet-657	36	10	and	and	CCONJ
admet-657	36	11	2aminooctanoic	2aminooctanoic	NUM
admet-657	36	12	acid	acid	NOUN
admet-657	36	13	were	be	AUX
admet-657	36	14	purchased	purchase	VERB
admet-657	36	15	from	from	ADP
admet-657	36	16	tci	tci	PROPN
admet-657	36	17	(	(	PUNCT
admet-657	36	18	tokyo	tokyo	PROPN
admet-657	36	19	,	,	PUNCT
admet-657	36	20	japan	japan	PROPN
admet-657	36	21	)	)	PUNCT
admet-657	36	22	.	.	PUNCT
admet-657	37	1	demeclocycline	demeclocycline	ADJ
admet-657	37	2	hydrochloride	hydrochloride	NOUN
admet-657	37	3	and	and	CCONJ
admet-657	37	4	chlortetracycline	chlortetracycline	VERB
admet-657	37	5	hydrochloride	hydrochloride	NOUN
admet-657	37	6	were	be	AUX
admet-657	37	7	purchased	purchase	VERB
admet-657	37	8	from	from	ADP
admet-657	37	9	lkt	lkt	PROPN
admet-657	37	10	labs	labs	PROPN
admet-657	37	11	,	,	PUNCT
admet-657	37	12	inc	inc	PROPN
admet-657	37	13	(	(	PUNCT
admet-657	37	14	mn	mn	PROPN
admet-657	37	15	,	,	PUNCT
admet-657	37	16	usa	usa	PROPN
admet-657	37	17	)	)	PUNCT
admet-657	37	18	.	.	PUNCT
admet-657	38	1	phosphatidylcholine	phosphatidylcholine	NOUN
admet-657	38	2	(	(	PUNCT
admet-657	38	3	pc	pc	NOUN
admet-657	38	4	)	)	PUNCT
admet-657	38	5	was	be	AUX
admet-657	38	6	purchased	purchase	VERB
admet-657	38	7	from	from	ADP
admet-657	38	8	nof	nof	PROPN
admet-657	38	9	corporation	corporation	PROPN
admet-657	38	10	(	(	PUNCT
admet-657	38	11	tokyo	tokyo	PROPN
admet-657	38	12	,	,	PUNCT
admet-657	38	13	japan	japan	PROPN
admet-657	38	14	)	)	PUNCT
admet-657	38	15	.	.	PUNCT
admet-657	39	1	tetrahexylamine	tetrahexylamine	PROPN
admet-657	39	2	bromide	bromide	NOUN
admet-657	39	3	(	(	PUNCT
admet-657	39	4	tha	tha	NOUN
admet-657	39	5	)	)	PUNCT
admet-657	39	6	was	be	AUX
admet-657	39	7	purchased	purchase	VERB
admet-657	39	8	from	from	ADP
admet-657	39	9	sigma	sigma	PROPN
admet-657	39	10	-	-	PUNCT
admet-657	39	11	aldrich	aldrich	PROPN
admet-657	39	12	co.	co.	PROPN
admet-657	39	13	llc	llc	PROPN
admet-657	39	14	(	(	PUNCT
admet-657	39	15	mo	mo	PROPN
admet-657	39	16	,	,	PUNCT
admet-657	39	17	usa	usa	PROPN
admet-657	39	18	)	)	PUNCT
admet-657	39	19	.	.	PUNCT
admet-657	40	1	procainamide	procainamide	ADJ
admet-657	40	2	hydrochloride	hydrochloride	NOUN
admet-657	40	3	was	be	AUX
admet-657	40	4	purchased	purchase	VERB
admet-657	40	5	from	from	ADP
admet-657	40	6	combi	combi	PROPN
admet-657	40	7	-	-	PUNCT
admet-657	40	8	blocks	blocks	PROPN
admet-657	40	9	inc	inc	PROPN
admet-657	40	10	(	(	PUNCT
admet-657	40	11	ca	ca	PROPN
admet-657	40	12	,	,	PUNCT
admet-657	40	13	admet	admet	PROPN
admet-657	40	14	&	&	CCONJ
admet-657	40	15	dmpk	dmpk	PROPN
admet-657	40	16	7(3	7(3	NUM
admet-657	40	17	)	)	PUNCT
admet-657	40	18	(	(	PUNCT
admet-657	40	19	2019	2019	NUM
admet-657	40	20	)	)	PUNCT
admet-657	40	21	151	151	NUM
admet-657	40	22	-	-	SYM
admet-657	40	23	160	160	NUM
admet-657	40	24	permeation	permeation	NOUN
admet-657	40	25	characteristics	characteristic	NOUN
admet-657	40	26	of	of	ADP
admet-657	40	27	tetracyclines	tetracyclines	PROPN
admet-657	40	28	in	in	ADP
admet-657	40	29	pampa	pampa	PROPN
admet-657	40	30	doi	doi	PROPN
admet-657	40	31	:	:	PUNCT
admet-657	40	32	10.5599	10.5599	NUM
admet-657	40	33	/	/	SYM
admet-657	40	34	admet.657	admet.657	PROPN
admet-657	40	35	153	153	NUM
admet-657	40	36	usa	usa	PROPN
admet-657	40	37	)	)	PUNCT
admet-657	40	38	.	.	PUNCT
admet-657	41	1	soy	soy	NOUN
admet-657	41	2	bean	bean	PROPN
admet-657	41	3	lecithins	lecithin	NOUN
admet-657	41	4	(	(	PUNCT
admet-657	41	5	slp	slp	NOUN
admet-657	41	6	-	-	PUNCT
admet-657	41	7	pc	pc	NOUN
admet-657	41	8	70	70	NUM
admet-657	41	9	,	,	PUNCT
admet-657	41	10	slp	slp	PROPN
admet-657	41	11	-	-	PUNCT
admet-657	41	12	white	white	PROPN
admet-657	41	13	,	,	PUNCT
admet-657	41	14	slp	slp	ADJ
admet-657	41	15	-	-	PUNCT
admet-657	41	16	pi	pi	NOUN
admet-657	41	17	grades	grade	NOUN
admet-657	41	18	)	)	PUNCT
admet-657	41	19	were	be	AUX
admet-657	41	20	provided	provide	VERB
admet-657	41	21	by	by	ADP
admet-657	41	22	tsuji	tsuji	PROPN
admet-657	41	23	oil	oil	PROPN
admet-657	41	24	mills	mills	PROPN
admet-657	41	25	co.	co.	PROPN
admet-657	41	26	,	,	PUNCT
admet-657	41	27	ltd	ltd	PROPN
admet-657	41	28	(	(	PUNCT
admet-657	41	29	mie	mie	PROPN
admet-657	41	30	,	,	PUNCT
admet-657	41	31	japan	japan	PROPN
admet-657	41	32	)	)	PUNCT
admet-657	41	33	.	.	PUNCT
admet-657	42	1	table	table	NOUN
admet-657	42	2	1	1	NUM
admet-657	42	3	.	.	PUNCT
admet-657	42	4	physicochemical	physicochemical	ADJ
admet-657	42	5	properties	property	NOUN
admet-657	42	6	of	of	ADP
admet-657	42	7	tetracyclines	tetracyclines	PROPN
admet-657	42	8	mw	mw	X
admet-657	42	9	pka	pka	PROPN
admet-657	42	10	log	log	NOUN
admet-657	42	11	d	d	PROPN
admet-657	42	12	(	(	PUNCT
admet-657	42	13	ph	ph	PROPN
admet-657	42	14	6.5	6.5	NUM
admet-657	42	15	)	)	PUNCT
admet-657	42	16	a	a	DET
admet-657	42	17	pka	pka	PROPN
admet-657	42	18	ref	ref	NOUN
admet-657	42	19	.	.	PUNCT
admet-657	43	1	chlortetracycline	chlortetracycline	VERB
admet-657	43	2	479	479	NUM
admet-657	43	3	3.3	3.3	NUM
admet-657	43	4	,	,	PUNCT
admet-657	43	5	7.6	7.6	NUM
admet-657	43	6	,	,	PUNCT
admet-657	43	7	9.3	9.3	NUM
admet-657	43	8	-0.88	-0.88	NUM
admet-657	43	9	(	(	PUNCT
admet-657	43	10	14	14	NUM
admet-657	43	11	)	)	PUNCT
admet-657	43	12	b	b	NOUN
admet-657	43	13	3.25	3.25	NUM
admet-657	43	14	,	,	PUNCT
admet-657	43	15	6.72	6.72	NUM
admet-657	43	16	,	,	PUNCT
admet-657	43	17	8.84	8.84	NUM
admet-657	43	18	(	(	PUNCT
admet-657	43	19	16	16	NUM
admet-657	43	20	)	)	PUNCT
admet-657	43	21	c	c	NOUN
admet-657	43	22	demeclocycline	demeclocycline	VERB
admet-657	43	23	465	465	NUM
admet-657	43	24	3.4	3.4	NUM
admet-657	43	25	,	,	PUNCT
admet-657	43	26	7.4	7.4	NUM
admet-657	43	27	,	,	PUNCT
admet-657	43	28	9.4	9.4	NUM
admet-657	43	29	-0.67	-0.67	NOUN
admet-657	43	30	(	(	PUNCT
admet-657	43	31	14	14	NUM
admet-657	43	32	)	)	PUNCT
admet-657	43	33	b	b	NOUN
admet-657	43	34	doxycycline	doxycycline	NOUN
admet-657	43	35	444	444	NUM
admet-657	43	36	3.0	3.0	NUM
admet-657	43	37	,	,	PUNCT
admet-657	43	38	8.0	8.0	NUM
admet-657	43	39	,	,	PUNCT
admet-657	43	40	9.2	9.2	NUM
admet-657	43	41	-0.08	-0.08	NUM
admet-657	43	42	(	(	PUNCT
admet-657	43	43	14	14	NUM
admet-657	43	44	)	)	PUNCT
admet-657	43	45	b	b	NOUN
admet-657	43	46	3.50	3.50	NUM
admet-657	43	47	,	,	PUNCT
admet-657	43	48	7.25	7.25	NUM
admet-657	43	49	,	,	PUNCT
admet-657	43	50	9.58	9.58	NUM
admet-657	43	51	(	(	PUNCT
admet-657	43	52	16	16	NUM
admet-657	43	53	)	)	PUNCT
admet-657	43	54	c	c	NOUN
admet-657	43	55	minocycline	minocycline	NOUN
admet-657	43	56	457	457	NUM
admet-657	43	57	2.8	2.8	NUM
admet-657	43	58	,	,	PUNCT
admet-657	43	59	5.0	5.0	NUM
admet-657	43	60	,	,	PUNCT
admet-657	43	61	7.8	7.8	NUM
admet-657	43	62	,	,	PUNCT
admet-657	43	63	9.5	9.5	NUM
admet-657	43	64	0.20	0.20	NUM
admet-657	43	65	(	(	PUNCT
admet-657	43	66	15	15	NUM
admet-657	43	67	)	)	PUNCT
admet-657	44	1	d	d	NOUN
admet-657	44	2	oxytetracycline	oxytetracycline	VERB
admet-657	44	3	460	460	NUM
admet-657	44	4	3.2	3.2	NUM
admet-657	44	5	,	,	PUNCT
admet-657	44	6	7.5	7.5	NUM
admet-657	44	7	,	,	PUNCT
admet-657	44	8	8.9	8.9	NUM
admet-657	44	9	-0.96	-0.96	NUM
admet-657	44	10	(	(	PUNCT
admet-657	44	11	14	14	NUM
admet-657	44	12	)	)	PUNCT
admet-657	44	13	b	b	NOUN
admet-657	44	14	3.53	3.53	NUM
admet-657	44	15	,	,	PUNCT
admet-657	44	16	7.25	7.25	NUM
admet-657	44	17	,	,	PUNCT
admet-657	44	18	9.58	9.58	NUM
admet-657	44	19	(	(	PUNCT
admet-657	44	20	16	16	NUM
admet-657	44	21	)	)	PUNCT
admet-657	44	22	c	c	NOUN
admet-657	44	23	tetracycline	tetracycline	VERB
admet-657	44	24	444	444	NUM
admet-657	44	25	3.3	3.3	NUM
admet-657	44	26	,	,	PUNCT
admet-657	44	27	7.8	7.8	NUM
admet-657	44	28	,	,	PUNCT
admet-657	44	29	9.6	9.6	NUM
admet-657	44	30	-1.09	-1.09	X
admet-657	44	31	(	(	PUNCT
admet-657	44	32	14	14	NUM
admet-657	44	33	)	)	PUNCT
admet-657	44	34	b	b	NOUN
admet-657	44	35	3.35	3.35	NUM
admet-657	44	36	,	,	PUNCT
admet-657	44	37	7.29	7.29	NUM
admet-657	44	38	,	,	PUNCT
admet-657	44	39	9.88	9.88	NUM
admet-657	44	40	(	(	PUNCT
admet-657	44	41	16	16	NUM
admet-657	44	42	)	)	PUNCT
admet-657	44	43	c	c	NOUN
admet-657	44	44	a	a	DET
admet-657	44	45	measured	measure	VERB
admet-657	44	46	in	in	ADP
admet-657	44	47	this	this	DET
admet-657	44	48	study	study	NOUN
admet-657	44	49	.	.	PUNCT
admet-657	45	1	b	b	X
admet-657	45	2	potentiometry	potentiometry	NOUN
admet-657	45	3	(	(	PUNCT
admet-657	45	4	23	23	NUM
admet-657	45	5	°	°	NOUN
admet-657	45	6	c	c	NOUN
admet-657	45	7	)	)	PUNCT
admet-657	45	8	,	,	PUNCT
admet-657	45	9	ionic	ionic	ADJ
admet-657	45	10	strength	strength	NOUN
admet-657	45	11	=	=	NOUN
admet-657	45	12	0.01	0.01	NUM
admet-657	45	13	or	or	CCONJ
admet-657	45	14	0.05	0.05	NUM
admet-657	45	15	m.	m.	NOUN
admet-657	45	16	c	c	PROPN
admet-657	45	17	potentiometry	potentiometry	NOUN
admet-657	45	18	(	(	PUNCT
admet-657	45	19	25	25	NUM
admet-657	45	20	°	°	NOUN
admet-657	45	21	c	c	NOUN
admet-657	45	22	)	)	PUNCT
admet-657	45	23	,	,	PUNCT
admet-657	45	24	ionic	ionic	ADJ
admet-657	45	25	strength	strength	NOUN
admet-657	45	26	=	=	SYM
admet-657	45	27	0.1	0.1	NUM
admet-657	45	28	m.	m.	NOUN
admet-657	45	29	d	d	NOUN
admet-657	45	30	method	method	NOUN
admet-657	45	31	not	not	PART
admet-657	45	32	described	describe	VERB
admet-657	45	33	in	in	ADP
admet-657	45	34	the	the	DET
admet-657	45	35	literature	literature	NOUN
admet-657	45	36	.	.	PUNCT
admet-657	46	1	table	table	NOUN
admet-657	46	2	2	2	NUM
admet-657	46	3	.	.	PUNCT
admet-657	46	4	lipid	lipid	NOUN
admet-657	46	5	composition	composition	NOUN
admet-657	46	6	of	of	ADP
admet-657	46	7	soy	soy	NOUN
admet-657	46	8	bean	bean	NOUN
admet-657	46	9	lecithin	lecithin	VERB
admet-657	46	10	a	a	DET
admet-657	46	11	phospholipid	phospholipid	NOUN
admet-657	46	12	slp	slp	PROPN
admet-657	46	13	-	-	PUNCT
admet-657	46	14	pc70	pc70	PROPN
admet-657	46	15	(	(	PUNCT
admet-657	46	16	%	%	INTJ
admet-657	46	17	)	)	PUNCT
admet-657	46	18	slp	slp	PROPN
admet-657	46	19	-	-	PUNCT
admet-657	46	20	white	white	ADJ
admet-657	46	21	(	(	PUNCT
admet-657	46	22	%	%	NOUN
admet-657	46	23	)	)	PUNCT
admet-657	46	24	slp	slp	PROPN
admet-657	46	25	-	-	PUNCT
admet-657	46	26	pi	pi	PROPN
admet-657	46	27	(	(	PUNCT
admet-657	46	28	%	%	INTJ
admet-657	46	29	)	)	PUNCT
admet-657	46	30	phosphatidylcholine	phosphatidylcholine	NOUN
admet-657	46	31	(	(	PUNCT
admet-657	46	32	pc	pc	NOUN
admet-657	46	33	)	)	PUNCT
admet-657	46	34	65	65	NUM
admet-657	46	35	–	–	PUNCT
admet-657	46	36	75	75	NUM
admet-657	46	37	24	24	NUM
admet-657	46	38	–	–	PUNCT
admet-657	46	39	32	32	NUM
admet-657	46	40	15	15	NUM
admet-657	46	41	–	–	SYM
admet-657	46	42	22	22	NUM
admet-657	46	43	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
admet-657	46	44	(	(	PUNCT
admet-657	46	45	pe	pe	NOUN
admet-657	46	46	)	)	PUNCT
admet-657	46	47	10	10	NUM
admet-657	46	48	–	–	PUNCT
admet-657	46	49	15	15	NUM
admet-657	46	50	20	20	NUM
admet-657	46	51	–	–	PUNCT
admet-657	46	52	28	28	NUM
admet-657	46	53	25	25	NUM
admet-657	46	54	–	–	SYM
admet-657	46	55	32	32	NUM
admet-657	46	56	phosphatidylinositol	phosphatidylinositol	NOUN
admet-657	46	57	(	(	PUNCT
admet-657	46	58	pi	pi	NOUN
admet-657	46	59	)	)	PUNCT
admet-657	46	60	0	0	NUM
admet-657	47	1	–	–	PUNCT
admet-657	47	2	1	1	NUM
admet-657	47	3	12	12	NUM
admet-657	47	4	–	–	PUNCT
admet-657	47	5	20	20	NUM
admet-657	47	6	18	18	NUM
admet-657	47	7	–	–	PUNCT
admet-657	47	8	25	25	NUM
admet-657	47	9	phosphatidic	phosphatidic	ADJ
admet-657	47	10	acid	acid	NOUN
admet-657	47	11	(	(	PUNCT
admet-657	47	12	pa	pa	PROPN
admet-657	47	13	)	)	PUNCT
admet-657	47	14	1	1	NUM
admet-657	47	15	–	–	PUNCT
admet-657	47	16	3	3	NUM
admet-657	47	17	8	8	NUM
admet-657	47	18	–	–	PUNCT
admet-657	47	19	15	15	NUM
admet-657	47	20	8	8	NUM
admet-657	47	21	–	–	SYM
admet-657	47	22	15	15	NUM
admet-657	47	23	lysophosphatidylcholines	lysophosphatidylcholine	NOUN
admet-657	47	24	(	(	PUNCT
admet-657	47	25	lpc	lpc	NOUN
admet-657	47	26	)	)	PUNCT
admet-657	47	27	1	1	NUM
admet-657	47	28	–	–	SYM
admet-657	47	29	5	5	NUM
admet-657	47	30	1	1	NUM
admet-657	47	31	–	–	SYM
admet-657	47	32	5	5	NUM
admet-657	47	33	1	1	NUM
admet-657	47	34	–	–	PUNCT
admet-657	47	35	5	5	NUM
admet-657	47	36	a	a	DET
admet-657	47	37	taken	take	VERB
admet-657	47	38	from	from	ADP
admet-657	47	39	the	the	DET
admet-657	47	40	product	product	NOUN
admet-657	47	41	information	information	NOUN
admet-657	47	42	provided	provide	VERB
admet-657	47	43	by	by	ADP
admet-657	47	44	the	the	DET
admet-657	47	45	manufacturer	manufacturer	NOUN
admet-657	47	46	.	.	PUNCT
admet-657	48	1	methods	method	NOUN
admet-657	48	2	pampa	pampa	PROPN
admet-657	48	3	assay	assay	VERB
admet-657	48	4	the	the	DET
admet-657	48	5	pampa	pampa	PROPN
admet-657	48	6	sandwich	sandwich	NOUN
admet-657	48	7	was	be	AUX
admet-657	48	8	consisted	consist	VERB
admet-657	48	9	of	of	ADP
admet-657	48	10	a	a	DET
admet-657	48	11	96	96	NUM
admet-657	48	12	well	well	NOUN
admet-657	48	13	filter	filter	NOUN
admet-657	48	14	plate	plate	NOUN
admet-657	48	15	(	(	PUNCT
admet-657	48	16	hydrophobic	hydrophobic	NOUN
admet-657	48	17	pvdf	pvdf	PROPN
admet-657	48	18	,	,	PUNCT
admet-657	48	19	0.45	0.45	NUM
admet-657	48	20	μm	μm	NOUN
admet-657	48	21	)	)	PUNCT
admet-657	48	22	and	and	CCONJ
admet-657	48	23	a	a	DET
admet-657	48	24	pampa	pampa	NOUN
admet-657	48	25	acceptor	acceptor	NOUN
admet-657	48	26	plate	plate	NOUN
admet-657	48	27	(	(	PUNCT
admet-657	48	28	merck	merck	PROPN
admet-657	48	29	millipore	millipore	PROPN
admet-657	48	30	,	,	PUNCT
admet-657	48	31	ma	ma	PROPN
admet-657	48	32	,	,	PUNCT
admet-657	48	33	usa	usa	PROPN
admet-657	48	34	)	)	PUNCT
admet-657	48	35	.	.	PUNCT
admet-657	49	1	before	before	ADP
admet-657	49	2	forming	form	VERB
admet-657	49	3	the	the	DET
admet-657	49	4	pampa	pampa	NOUN
admet-657	49	5	sandwich	sandwich	NOUN
admet-657	49	6	,	,	PUNCT
admet-657	49	7	the	the	DET
admet-657	49	8	bottom	bottom	NOUN
admet-657	49	9	(	(	PUNCT
admet-657	49	10	acceptor	acceptor	NOUN
admet-657	49	11	)	)	PUNCT
admet-657	49	12	plate	plate	NOUN
admet-657	49	13	was	be	AUX
admet-657	49	14	filled	fill	VERB
admet-657	49	15	with	with	ADP
admet-657	49	16	300	300	NUM
admet-657	49	17	μl	μl	ADP
admet-657	49	18	of	of	ADP
admet-657	49	19	a	a	DET
admet-657	49	20	50	50	NUM
admet-657	49	21	mm	mm	NOUN
admet-657	49	22	sodium	sodium	NOUN
admet-657	49	23	phosphate	phosphate	NOUN
admet-657	49	24	buffer	buffer	NOUN
admet-657	49	25	.	.	PUNCT
admet-657	50	1	the	the	DET
admet-657	50	2	filter	filter	NOUN
admet-657	50	3	of	of	ADP
admet-657	50	4	the	the	DET
admet-657	50	5	top	top	ADJ
admet-657	50	6	(	(	PUNCT
admet-657	50	7	donor	donor	NOUN
admet-657	50	8	)	)	PUNCT
admet-657	50	9	compartment	compartment	NOUN
admet-657	50	10	was	be	AUX
admet-657	50	11	coated	coat	VERB
admet-657	50	12	with	with	ADP
admet-657	50	13	5	5	NUM
admet-657	50	14	μl	μl	ADP
admet-657	50	15	of	of	ADP
admet-657	50	16	a	a	DET
admet-657	50	17	phospholipid	phospholipid	NOUN
admet-657	50	18	–	–	PUNCT
admet-657	50	19	decane	decane	NOUN
admet-657	50	20	solution	solution	NOUN
admet-657	50	21	.	.	PUNCT
admet-657	51	1	the	the	DET
admet-657	51	2	compositions	composition	NOUN
admet-657	51	3	of	of	ADP
admet-657	51	4	soy	soy	NOUN
admet-657	51	5	bean	bean	NOUN
admet-657	51	6	lecithins	lecithin	NOUN
admet-657	51	7	were	be	AUX
admet-657	51	8	shown	show	VERB
admet-657	51	9	in	in	ADP
admet-657	51	10	table	table	NOUN
admet-657	51	11	2	2	NUM
admet-657	51	12	.	.	PUNCT
admet-657	52	1	the	the	DET
admet-657	52	2	buffer	buffer	NOUN
admet-657	52	3	conditions	condition	NOUN
admet-657	52	4	were	be	AUX
admet-657	52	5	the	the	DET
admet-657	52	6	same	same	ADJ
admet-657	52	7	for	for	ADP
admet-657	52	8	both	both	CCONJ
admet-657	52	9	donor	donor	NOUN
admet-657	52	10	and	and	CCONJ
admet-657	52	11	acceptor	acceptor	NOUN
admet-657	52	12	compartments	compartment	NOUN
admet-657	52	13	(	(	PUNCT
admet-657	52	14	iso	iso	NOUN
admet-657	52	15	-	-	PUNCT
admet-657	52	16	ph	ph	ADJ
admet-657	52	17	and	and	CCONJ
admet-657	52	18	iso	iso	NOUN
admet-657	52	19	-	-	PUNCT
admet-657	52	20	ionic	ionic	ADJ
admet-657	52	21	strength	strength	NOUN
admet-657	52	22	condition	condition	NOUN
admet-657	52	23	)	)	PUNCT
admet-657	52	24	.	.	PUNCT
admet-657	53	1	the	the	DET
admet-657	53	2	pampa	pampa	PROPN
admet-657	53	3	sandwich	sandwich	NOUN
admet-657	53	4	was	be	AUX
admet-657	53	5	placed	place	VERB
admet-657	53	6	in	in	ADP
admet-657	53	7	a	a	DET
admet-657	53	8	plastic	plastic	ADJ
admet-657	53	9	container	container	NOUN
admet-657	53	10	containing	contain	VERB
admet-657	53	11	a	a	DET
admet-657	53	12	small	small	ADJ
admet-657	53	13	amount	amount	NOUN
admet-657	53	14	of	of	ADP
admet-657	53	15	water	water	NOUN
admet-657	53	16	on	on	ADP
admet-657	53	17	the	the	DET
admet-657	53	18	bottom	bottom	NOUN
admet-657	53	19	and	and	CCONJ
admet-657	53	20	incubated	incubate	VERB
admet-657	53	21	for	for	ADP
admet-657	53	22	3	3	NUM
admet-657	53	23	h	h	NOUN
admet-657	53	24	(	(	PUNCT
admet-657	53	25	at	at	ADP
admet-657	53	26	25	25	NUM
admet-657	53	27	and	and	CCONJ
admet-657	53	28	37	37	NUM
admet-657	53	29	°	°	NOUN
admet-657	53	30	c	c	NOUN
admet-657	53	31	)	)	PUNCT
admet-657	53	32	or	or	CCONJ
admet-657	53	33	18	18	NUM
admet-657	53	34	h	h	NOUN
admet-657	53	35	(	(	PUNCT
admet-657	53	36	at	at	ADP
admet-657	53	37	15	15	NUM
admet-657	53	38	°	°	NOUN
admet-657	53	39	c	c	NOUN
admet-657	53	40	)	)	PUNCT
admet-657	53	41	.	.	PUNCT
admet-657	54	1	after	after	ADP
admet-657	54	2	incubation	incubation	NOUN
admet-657	54	3	,	,	PUNCT
admet-657	54	4	100	100	NUM
admet-657	54	5	μl	μl	ADP
admet-657	54	6	of	of	ADP
admet-657	54	7	both	both	CCONJ
admet-657	54	8	the	the	DET
admet-657	54	9	donor	donor	NOUN
admet-657	54	10	and	and	CCONJ
admet-657	54	11	acceptor	acceptor	NOUN
admet-657	54	12	solutions	solution	NOUN
admet-657	54	13	were	be	AUX
admet-657	54	14	transferred	transfer	VERB
admet-657	54	15	to	to	ADP
admet-657	54	16	uv	uv	NOUN
admet-657	54	17	plates	plate	NOUN
admet-657	54	18	.	.	PUNCT
admet-657	55	1	the	the	DET
admet-657	55	2	concentrations	concentration	NOUN
admet-657	55	3	of	of	ADP
admet-657	55	4	tetracyclines	tetracycline	NOUN
admet-657	55	5	and	and	CCONJ
admet-657	55	6	procainamide	procainamide	NOUN
admet-657	55	7	were	be	AUX
admet-657	55	8	measured	measure	VERB
admet-657	55	9	at	at	ADP
admet-657	55	10	360	360	NUM
admet-657	55	11	and	and	CCONJ
admet-657	55	12	280	280	NUM
admet-657	55	13	nm	nm	NOUN
admet-657	55	14	,	,	PUNCT
admet-657	55	15	respectively	respectively	ADV
admet-657	55	16	.	.	PUNCT
admet-657	56	1	the	the	DET
admet-657	56	2	pampa	pampa	PROPN
admet-657	56	3	permeability	permeability	NOUN
admet-657	56	4	was	be	AUX
admet-657	56	5	calculated	calculate	VERB
admet-657	56	6	by	by	ADP
admet-657	56	7	the	the	DET
admet-657	56	8	following	follow	VERB
admet-657	56	9	equation	equation	NOUN
admet-657	56	10	[	[	X
admet-657	56	11	19	19	NUM
admet-657	56	12	]	]	X
admet-657	56	13	:	:	PUNCT
admet-657	57	1	d	d	X
admet-657	57	2	v	v	X
admet-657	57	3	d	d	PROPN
admet-657	57	4	v	v	NOUN
admet-657	57	5	v	v	NOUN
admet-657	57	6	d	d	PROPN
admet-657	57	7	2.303	2.303	NUM
admet-657	57	8	1	1	NUM
admet-657	57	9	(	(	PUNCT
admet-657	57	10	)	)	PUNCT
admet-657	57	11	1	1	NUM
admet-657	57	12	log	log	VERB
admet-657	57	13	1	1	NUM
admet-657	57	14	1	1	NUM
admet-657	57	15	(	(	PUNCT
admet-657	57	16	0	0	NUM
admet-657	57	17	)	)	PUNCT
admet-657	57	18	e	e	NOUN
admet-657	57	19	v	v	NOUN
admet-657	57	20	r	r	NOUN
admet-657	57	21	c	c	NOUN
admet-657	57	22	t	t	NOUN
admet-657	57	23	p	p	NOUN
admet-657	57	24	r	r	NOUN
admet-657	57	25	a	a	DET
admet-657	57	26	t	t	NOUN
admet-657	57	27	r	r	NOUN
admet-657	57	28	r	r	NOUN
admet-657	57	29	c	c	NOUN
admet-657	57	30			NOUN
admet-657	57	31			PROPN
admet-657	57	32			NOUN
admet-657	57	33			NOUN
admet-657	57	34			VERB
admet-657	57	35			PROPN
admet-657	57	36			PROPN
admet-657	57	37			PROPN
admet-657	57	38			PROPN
admet-657	57	39			PROPN
admet-657	57	40			PROPN
admet-657	57	41			PROPN
admet-657	57	42			VERB
admet-657	58	1			PROPN
admet-657	59	1			NUM
admet-657	59	2			PUNCT
admet-657	59	3			NOUN
admet-657	59	4			PRON
admet-657	59	5			NOUN
admet-657	59	6			PROPN
admet-657	59	7			NOUN
admet-657	59	8	(	(	PUNCT
admet-657	59	9	1	1	NUM
admet-657	59	10	)	)	PUNCT
admet-657	59	11	d	d	NOUN
admet-657	59	12	a	a	PRON
admet-657	59	13	d	d	X
admet-657	59	14	v	v	X
admet-657	59	15	d	d	PROPN
admet-657	59	16	(	(	PUNCT
admet-657	59	17	)	)	PUNCT
admet-657	59	18	(	(	PUNCT
admet-657	59	19	)	)	SYM
admet-657	59	20	1	1	NUM
admet-657	59	21	1	1	NUM
admet-657	59	22	(	(	PUNCT
admet-657	59	23	0	0	NUM
admet-657	59	24	)	)	PUNCT
admet-657	59	25	(	(	PUNCT
admet-657	59	26	0	0	NUM
admet-657	59	27	)	)	PUNCT
admet-657	59	28	c	c	NOUN
admet-657	60	1	t	t	PROPN
admet-657	60	2	c	c	NOUN
admet-657	60	3	t	t	NOUN
admet-657	60	4	r	r	NOUN
admet-657	61	1	c	c	NOUN
admet-657	61	2	r	r	NOUN
admet-657	61	3	c	c	NOUN
admet-657	61	4			PROPN
admet-657	61	5			PROPN
admet-657	61	6			NOUN
admet-657	61	7	(	(	PUNCT
admet-657	61	8	2	2	NUM
admet-657	61	9	)	)	PUNCT
admet-657	61	10	yamauchi	yamauchi	NOUN
admet-657	61	11	and	and	CCONJ
admet-657	61	12	sugano	sugano	VERB
admet-657	61	13	admet	admet	PROPN
admet-657	61	14	&	&	CCONJ
admet-657	61	15	dmpk	dmpk	PROPN
admet-657	61	16	7(3	7(3	NUM
admet-657	61	17	)	)	PUNCT
admet-657	61	18	(	(	PUNCT
admet-657	61	19	2019	2019	NUM
admet-657	61	20	)	)	PUNCT
admet-657	61	21	151	151	NUM
admet-657	61	22	-	-	SYM
admet-657	61	23	160	160	NUM
admet-657	61	24	154	154	NUM
admet-657	61	25	d	d	NOUN
admet-657	61	26	v	v	ADP
admet-657	61	27	a	a	DET
admet-657	61	28	v	v	NOUN
admet-657	61	29	r	r	NOUN
admet-657	61	30	v	v	NOUN
admet-657	61	31			NOUN
admet-657	62	1	(	(	PUNCT
admet-657	62	2	3	3	NUM
admet-657	62	3	)	)	PUNCT
admet-657	62	4	where	where	SCONJ
admet-657	62	5	pe	pe	PROPN
admet-657	62	6	is	be	AUX
admet-657	62	7	the	the	DET
admet-657	62	8	effective	effective	ADJ
admet-657	62	9	permeation	permeation	NOUN
admet-657	62	10	coefficient	coefficient	NOUN
admet-657	62	11	(	(	PUNCT
admet-657	62	12	cm	cm	NOUN
admet-657	62	13	/	/	SYM
admet-657	62	14	s	s	NOUN
admet-657	62	15	)	)	PUNCT
admet-657	62	16	,	,	PUNCT
admet-657	62	17	a	a	PRON
admet-657	62	18	is	be	AUX
admet-657	62	19	the	the	DET
admet-657	62	20	filter	filter	NOUN
admet-657	62	21	surface	surface	NOUN
admet-657	62	22	area	area	NOUN
admet-657	62	23	(	(	PUNCT
admet-657	62	24	0.266	0.266	NUM
admet-657	62	25	cm	cm	NOUN
admet-657	62	26	2	2	NUM
admet-657	62	27	)	)	PUNCT
admet-657	62	28	,	,	PUNCT
admet-657	62	29	vd	vd	NOUN
admet-657	62	30	and	and	CCONJ
admet-657	62	31	va	va	PROPN
admet-657	62	32	are	be	AUX
admet-657	62	33	the	the	DET
admet-657	62	34	volumes	volume	NOUN
admet-657	62	35	in	in	ADP
admet-657	62	36	the	the	DET
admet-657	62	37	donor	donor	NOUN
admet-657	62	38	and	and	CCONJ
admet-657	62	39	acceptor	acceptor	NOUN
admet-657	62	40	phase	phase	NOUN
admet-657	62	41	(	(	PUNCT
admet-657	62	42	0.15	0.15	NUM
admet-657	62	43	and	and	CCONJ
admet-657	62	44	0.3	0.3	NUM
admet-657	62	45	ml	ml	NOUN
admet-657	62	46	,	,	PUNCT
admet-657	62	47	respectively	respectively	ADV
admet-657	62	48	)	)	PUNCT
admet-657	62	49	,	,	PUNCT
admet-657	62	50	t	t	PROPN
admet-657	62	51	is	be	AUX
admet-657	62	52	the	the	DET
admet-657	62	53	incubation	incubation	NOUN
admet-657	62	54	time	time	NOUN
admet-657	62	55	,	,	PUNCT
admet-657	62	56	cd(t	cd(t	PUNCT
admet-657	62	57	)	)	PUNCT
admet-657	62	58	is	be	AUX
admet-657	62	59	the	the	DET
admet-657	62	60	concentration	concentration	NOUN
admet-657	62	61	of	of	ADP
admet-657	62	62	a	a	DET
admet-657	62	63	drug	drug	NOUN
admet-657	62	64	in	in	ADP
admet-657	62	65	the	the	DET
admet-657	62	66	donor	donor	NOUN
admet-657	62	67	phase	phase	NOUN
admet-657	62	68	at	at	ADP
admet-657	62	69	time	time	NOUN
admet-657	62	70	t	t	PROPN
admet-657	62	71	,	,	PUNCT
admet-657	62	72	r	r	NOUN
admet-657	62	73	is	be	AUX
admet-657	62	74	the	the	DET
admet-657	62	75	membrane	membrane	NOUN
admet-657	62	76	retention	retention	NOUN
admet-657	62	77	factor	factor	NOUN
admet-657	62	78	,	,	PUNCT
admet-657	62	79	and	and	CCONJ
admet-657	62	80	rv	rv	PROPN
admet-657	62	81	is	be	AUX
admet-657	62	82	the	the	DET
admet-657	62	83	volume	volume	NOUN
admet-657	62	84	ratio	ratio	NOUN
admet-657	62	85	.	.	PUNCT
admet-657	63	1	octanol	octanol	NOUN
admet-657	63	2	-	-	PUNCT
admet-657	63	3	buffer	buffer	NOUN
admet-657	63	4	distribution	distribution	NOUN
admet-657	63	5	coefficient	coefficient	VERB
admet-657	63	6	the	the	DET
admet-657	63	7	octanol	octanol	NOUN
admet-657	63	8	-	-	PUNCT
admet-657	63	9	buffer	buffer	NOUN
admet-657	63	10	distribution	distribution	NOUN
admet-657	63	11	coefficients	coefficient	NOUN
admet-657	63	12	(	(	PUNCT
admet-657	63	13	log	log	NOUN
admet-657	63	14	d	d	NOUN
admet-657	63	15	)	)	PUNCT
admet-657	63	16	of	of	ADP
admet-657	63	17	tetracyclines	tetracycline	NOUN
admet-657	63	18	were	be	AUX
admet-657	63	19	determined	determine	VERB
admet-657	63	20	by	by	ADP
admet-657	63	21	a	a	DET
admet-657	63	22	shake	shake	NOUN
admet-657	63	23	-	-	PUNCT
admet-657	63	24	flask	flask	NOUN
admet-657	63	25	method	method	NOUN
admet-657	63	26	at	at	ADP
admet-657	63	27	ph	ph	PROPN
admet-657	63	28	6.5	6.5	NUM
admet-657	63	29	(	(	PUNCT
admet-657	63	30	50	50	NUM
admet-657	63	31	mm	mm	NUM
admet-657	63	32	sodium	sodium	NOUN
admet-657	63	33	–	–	PUNCT
admet-657	63	34	phosphate	phosphate	NOUN
admet-657	63	35	buffer	buffer	NOUN
admet-657	63	36	)	)	PUNCT
admet-657	63	37	.	.	PUNCT
admet-657	64	1	the	the	DET
admet-657	64	2	octanol	octanol	NOUN
admet-657	64	3	and	and	CCONJ
admet-657	64	4	buffer	buffer	VERB
admet-657	64	5	phases	phase	NOUN
admet-657	64	6	were	be	AUX
admet-657	64	7	mutually	mutually	ADV
admet-657	64	8	presaturated	presaturate	VERB
admet-657	64	9	before	before	ADP
admet-657	64	10	use	use	NOUN
admet-657	64	11	.	.	PUNCT
admet-657	65	1	a	a	DET
admet-657	65	2	buffer	buffer	NOUN
admet-657	65	3	solution	solution	NOUN
admet-657	65	4	of	of	ADP
admet-657	65	5	a	a	DET
admet-657	65	6	model	model	NOUN
admet-657	65	7	drug	drug	NOUN
admet-657	65	8	(	(	PUNCT
admet-657	65	9	1.0	1.0	NUM
admet-657	65	10	mm	mm	NOUN
admet-657	65	11	,	,	PUNCT
admet-657	65	12	0.5	0.5	NUM
admet-657	65	13	ml	ml	NOUN
admet-657	65	14	)	)	PUNCT
admet-657	65	15	and	and	CCONJ
admet-657	65	16	octanol	octanol	NOUN
admet-657	65	17	(	(	PUNCT
admet-657	65	18	2.5	2.5	NUM
admet-657	65	19	ml	ml	NOUN
admet-657	65	20	)	)	PUNCT
admet-657	65	21	were	be	AUX
admet-657	65	22	added	add	VERB
admet-657	65	23	to	to	ADP
admet-657	65	24	a	a	DET
admet-657	65	25	15	15	NUM
admet-657	65	26	ml	ml	NOUN
admet-657	65	27	tube	tube	NOUN
admet-657	65	28	.	.	PUNCT
admet-657	66	1	the	the	DET
admet-657	66	2	sample	sample	NOUN
admet-657	66	3	was	be	AUX
admet-657	66	4	vigorously	vigorously	ADV
admet-657	66	5	shaken	shake	VERB
admet-657	66	6	for	for	ADP
admet-657	66	7	60	60	NUM
admet-657	66	8	min	min	NOUN
admet-657	66	9	at	at	ADP
admet-657	66	10	room	room	NOUN
admet-657	66	11	temperature	temperature	NOUN
admet-657	66	12	.	.	PUNCT
admet-657	67	1	the	the	DET
admet-657	67	2	concentrations	concentration	NOUN
admet-657	67	3	of	of	ADP
admet-657	67	4	tetracyclines	tetracycline	NOUN
admet-657	67	5	were	be	AUX
admet-657	67	6	determined	determine	VERB
admet-657	67	7	by	by	ADP
admet-657	67	8	uv	uv	NOUN
admet-657	67	9	spectroscopy	spectroscopy	NOUN
admet-657	67	10	at	at	ADP
admet-657	67	11	360	360	NUM
admet-657	67	12	nm	nm	NOUN
admet-657	67	13	.	.	PUNCT
admet-657	68	1	results	result	VERB
admet-657	68	2	effect	effect	NOUN
admet-657	68	3	of	of	ADP
admet-657	68	4	membrane	membrane	NOUN
admet-657	68	5	composition	composition	NOUN
admet-657	68	6	the	the	DET
admet-657	68	7	pampa	pampa	PROPN
admet-657	68	8	permeation	permeation	NOUN
admet-657	68	9	of	of	ADP
admet-657	68	10	tetracycline	tetracycline	PROPN
admet-657	68	11	(	(	PUNCT
admet-657	68	12	tc	tc	NOUN
admet-657	68	13	)	)	PUNCT
admet-657	68	14	was	be	AUX
admet-657	68	15	markedly	markedly	ADV
admet-657	68	16	affected	affect	VERB
admet-657	68	17	by	by	ADP
admet-657	68	18	the	the	DET
admet-657	68	19	lipid	lipid	NOUN
admet-657	68	20	composition	composition	NOUN
admet-657	68	21	of	of	ADP
admet-657	68	22	the	the	DET
admet-657	68	23	pampa	pampa	NOUN
admet-657	68	24	membrane	membrane	NOUN
admet-657	68	25	(	(	PUNCT
admet-657	68	26	figure	figure	NOUN
admet-657	68	27	2	2	NUM
admet-657	68	28	)	)	PUNCT
admet-657	68	29	.	.	PUNCT
admet-657	69	1	no	no	DET
admet-657	69	2	permeation	permeation	NOUN
admet-657	69	3	was	be	AUX
admet-657	69	4	observed	observe	VERB
admet-657	69	5	when	when	SCONJ
admet-657	69	6	phospholipid	phospholipid	NOUN
admet-657	69	7	was	be	AUX
admet-657	69	8	not	not	PART
admet-657	69	9	added	add	VERB
admet-657	69	10	(	(	PUNCT
admet-657	69	11	pure	pure	ADJ
admet-657	69	12	decane	decane	NOUN
admet-657	69	13	membrane	membrane	NOUN
admet-657	69	14	,	,	PUNCT
admet-657	69	15	pe	pe	X
admet-657	69	16	<	<	X
admet-657	69	17	0.05	0.05	NUM
admet-657	69	18	×	×	NOUN
admet-657	69	19	10	10	NUM
admet-657	69	20	-	-	SYM
admet-657	69	21	6	6	NUM
admet-657	69	22	cm	cm	NOUN
admet-657	69	23	/	/	SYM
admet-657	69	24	sec	sec	PROPN
admet-657	69	25	)	)	PUNCT
admet-657	69	26	.	.	PUNCT
admet-657	70	1	with	with	ADP
admet-657	70	2	the	the	DET
admet-657	70	3	addition	addition	NOUN
admet-657	70	4	of	of	ADP
admet-657	70	5	2	2	NUM
admet-657	70	6	%	%	NOUN
admet-657	70	7	pc	pc	NOUN
admet-657	70	8	,	,	PUNCT
admet-657	70	9	little	little	ADJ
admet-657	70	10	or	or	CCONJ
admet-657	70	11	no	no	PRON
admet-657	70	12	increase	increase	NOUN
admet-657	70	13	in	in	ADP
admet-657	70	14	pe	pe	PROPN
admet-657	70	15	was	be	AUX
admet-657	70	16	observed	observe	VERB
admet-657	70	17	.	.	PUNCT
admet-657	71	1	the	the	DET
admet-657	71	2	addition	addition	NOUN
admet-657	71	3	of	of	ADP
admet-657	71	4	1	1	NUM
admet-657	71	5	%	%	NOUN
admet-657	71	6	pe	pe	PROPN
admet-657	71	7	increased	increase	VERB
admet-657	71	8	the	the	DET
admet-657	71	9	pe	pe	PROPN
admet-657	71	10	value	value	NOUN
admet-657	71	11	more	more	ADV
admet-657	71	12	than	than	ADP
admet-657	71	13	tenfold	tenfold	ADV
admet-657	71	14	.	.	PUNCT
admet-657	72	1	the	the	DET
admet-657	72	2	addition	addition	NOUN
admet-657	72	3	of	of	ADP
admet-657	72	4	2	2	NUM
admet-657	72	5	%	%	NOUN
admet-657	72	6	soybean	soybean	NOUN
admet-657	72	7	lecithin	lecithin	NOUN
admet-657	72	8	containing	contain	VERB
admet-657	72	9	phosphatidylinositol	phosphatidylinositol	NOUN
admet-657	72	10	(	(	PUNCT
admet-657	72	11	pi	pi	NOUN
admet-657	72	12	)	)	PUNCT
admet-657	72	13	and	and	CCONJ
admet-657	72	14	phosphatidic	phosphatidic	ADJ
admet-657	72	15	acid	acid	NOUN
admet-657	72	16	(	(	PUNCT
admet-657	72	17	pa	pa	PROPN
admet-657	72	18	)	)	PUNCT
admet-657	72	19	increased	increase	VERB
admet-657	72	20	the	the	DET
admet-657	72	21	pe	pe	PROPN
admet-657	72	22	value	value	NOUN
admet-657	72	23	to	to	ADP
admet-657	72	24	above	above	ADP
admet-657	72	25	4∙10	4∙10	NUM
admet-657	72	26	-6	-6	NOUN
admet-657	72	27	cm	cm	PROPN
admet-657	72	28	/	/	SYM
admet-657	72	29	sec	sec	PROPN
admet-657	72	30	.	.	PUNCT
admet-657	73	1	the	the	DET
admet-657	73	2	pe	pe	PROPN
admet-657	73	3	value	value	NOUN
admet-657	73	4	was	be	AUX
admet-657	73	5	further	far	ADV
admet-657	73	6	increased	increase	VERB
admet-657	73	7	to	to	ADP
admet-657	73	8	15∙10	15∙10	NUM
admet-657	73	9	-6	-6	PROPN
admet-657	73	10	cm	cm	NOUN
admet-657	73	11	/	/	SYM
admet-657	73	12	sec	sec	PROPN
admet-657	73	13	by	by	ADP
admet-657	73	14	increasing	increase	VERB
admet-657	73	15	the	the	DET
admet-657	73	16	concentration	concentration	NOUN
admet-657	73	17	of	of	ADP
admet-657	73	18	soybean	soybean	NOUN
admet-657	73	19	lecithin	lecithin	NOUN
admet-657	73	20	from	from	ADP
admet-657	73	21	2	2	NUM
admet-657	73	22	to	to	PART
admet-657	73	23	10	10	NUM
admet-657	73	24	%	%	NOUN
admet-657	73	25	.	.	PUNCT
admet-657	74	1	the	the	DET
admet-657	74	2	10	10	NUM
admet-657	74	3	%	%	NOUN
admet-657	74	4	soybean	soybean	NOUN
admet-657	74	5	lecithin	lecithin	NOUN
admet-657	74	6	(	(	PUNCT
admet-657	74	7	slp	slp	PROPN
admet-657	74	8	white	white	PROPN
admet-657	74	9	)	)	PUNCT
admet-657	74	10	decane	decane	NOUN
admet-657	74	11	membrane	membrane	NOUN
admet-657	74	12	was	be	AUX
admet-657	74	13	used	use	VERB
admet-657	74	14	in	in	ADP
admet-657	74	15	the	the	DET
admet-657	74	16	following	follow	VERB
admet-657	74	17	studies	study	NOUN
admet-657	74	18	.	.	PUNCT
admet-657	75	1	figure	figure	NOUN
admet-657	75	2	2	2	NUM
admet-657	75	3	.	.	PUNCT
admet-657	75	4	effect	effect	NOUN
admet-657	75	5	of	of	ADP
admet-657	75	6	membrane	membrane	NOUN
admet-657	75	7	composition	composition	NOUN
admet-657	75	8	on	on	ADP
admet-657	75	9	pampa	pampa	PROPN
admet-657	75	10	permeation	permeation	NOUN
admet-657	75	11	of	of	ADP
admet-657	75	12	tetracycline	tetracycline	NOUN
admet-657	75	13	(	(	PUNCT
admet-657	75	14	mean	mean	PROPN
admet-657	75	15	±	±	NUM
admet-657	75	16	sd	sd	NOUN
admet-657	75	17	,	,	PUNCT
admet-657	75	18	n	n	NOUN
admet-657	75	19	=	=	SYM
admet-657	75	20	3	3	NUM
admet-657	75	21	9	9	NUM
admet-657	75	22	)	)	PUNCT
admet-657	75	23	.	.	PUNCT
admet-657	76	1	assay	assay	NOUN
admet-657	76	2	conditions	condition	NOUN
admet-657	76	3	:	:	PUNCT
admet-657	76	4	tc	tc	NUM
admet-657	76	5	0.5	0.5	NUM
admet-657	76	6	mm	mm	NOUN
admet-657	76	7	,	,	PUNCT
admet-657	76	8	10	10	NUM
admet-657	76	9	%	%	NOUN
admet-657	76	10	slp	slp	PROPN
admet-657	76	11	-	-	PUNCT
admet-657	76	12	white	white	ADJ
admet-657	76	13	/	/	SYM
admet-657	76	14	decane	decane	NOUN
admet-657	76	15	,	,	PUNCT
admet-657	76	16	ph	ph	VERB
admet-657	76	17	6.5	6.5	NUM
admet-657	76	18	50	50	NUM
admet-657	76	19	mm	mm	NUM
admet-657	76	20	sodium	sodium	NOUN
admet-657	76	21	phosphate	phosphate	NOUN
admet-657	76	22	buffer	buffer	NOUN
admet-657	76	23	,	,	PUNCT
admet-657	76	24	37	37	NUM
admet-657	76	25	°	°	NOUN
admet-657	76	26	c	c	X
admet-657	76	27	.	.	PUNCT
admet-657	77	1	admet	admet	PROPN
admet-657	77	2	&	&	CCONJ
admet-657	77	3	dmpk	dmpk	PROPN
admet-657	77	4	7(3	7(3	NUM
admet-657	77	5	)	)	PUNCT
admet-657	77	6	(	(	PUNCT
admet-657	77	7	2019	2019	NUM
admet-657	77	8	)	)	PUNCT
admet-657	77	9	151	151	NUM
admet-657	77	10	-	-	SYM
admet-657	77	11	160	160	NUM
admet-657	77	12	permeation	permeation	NOUN
admet-657	77	13	characteristics	characteristic	NOUN
admet-657	77	14	of	of	ADP
admet-657	77	15	tetracyclines	tetracyclines	PROPN
admet-657	77	16	in	in	ADP
admet-657	77	17	pampa	pampa	PROPN
admet-657	77	18	doi	doi	PROPN
admet-657	77	19	:	:	PUNCT
admet-657	77	20	10.5599	10.5599	NUM
admet-657	77	21	/	/	SYM
admet-657	77	22	admet.657	admet.657	PROPN
admet-657	77	23	155	155	NUM
admet-657	77	24	ph	ph	ADJ
admet-657	77	25	and	and	CCONJ
admet-657	77	26	ionic	ionic	ADJ
admet-657	77	27	strength	strength	NOUN
admet-657	77	28	dependency	dependency	NOUN
admet-657	77	29	the	the	DET
admet-657	77	30	effect	effect	NOUN
admet-657	77	31	of	of	ADP
admet-657	77	32	ph	ph	NOUN
admet-657	77	33	on	on	ADP
admet-657	77	34	the	the	DET
admet-657	77	35	pampa	pampa	PROPN
admet-657	77	36	permeation	permeation	NOUN
admet-657	77	37	of	of	ADP
admet-657	77	38	tc	tc	NOUN
admet-657	77	39	is	be	AUX
admet-657	77	40	shown	show	VERB
admet-657	77	41	in	in	ADP
admet-657	77	42	figure	figure	NOUN
admet-657	77	43	3	3	NUM
admet-657	77	44	.	.	PUNCT
admet-657	78	1	the	the	DET
admet-657	78	2	pe	pe	PROPN
admet-657	78	3	values	value	NOUN
admet-657	78	4	decreased	decrease	VERB
admet-657	78	5	as	as	SCONJ
admet-657	78	6	ph	ph	NOUN
admet-657	78	7	was	be	AUX
admet-657	78	8	increased	increase	VERB
admet-657	78	9	above	above	ADP
admet-657	78	10	7.0	7.0	NUM
admet-657	78	11	.	.	PUNCT
admet-657	79	1	the	the	DET
admet-657	79	2	effect	effect	NOUN
admet-657	79	3	of	of	ADP
admet-657	79	4	the	the	DET
admet-657	79	5	ionic	ionic	ADJ
admet-657	79	6	strength	strength	NOUN
admet-657	79	7	(	(	PUNCT
admet-657	79	8	i	i	NOUN
admet-657	79	9	)	)	PUNCT
admet-657	79	10	is	be	AUX
admet-657	79	11	shown	show	VERB
admet-657	79	12	in	in	ADP
admet-657	79	13	figure	figure	NOUN
admet-657	79	14	4	4	NUM
admet-657	79	15	.	.	PUNCT
admet-657	80	1	the	the	DET
admet-657	80	2	ionic	ionic	ADJ
admet-657	80	3	strength	strength	NOUN
admet-657	80	4	showed	show	VERB
admet-657	80	5	little	little	ADJ
admet-657	80	6	or	or	CCONJ
admet-657	80	7	no	no	PRON
admet-657	80	8	effect	effect	NOUN
admet-657	80	9	in	in	ADP
admet-657	80	10	the	the	DET
admet-657	80	11	range	range	NOUN
admet-657	80	12	of	of	ADP
admet-657	80	13	i	i	NOUN
admet-657	80	14	=	=	PROPN
admet-657	80	15	0.15	0.15	NUM
admet-657	80	16	to	to	ADP
admet-657	80	17	2.0	2.0	NUM
admet-657	80	18	m.	m.	NOUN
admet-657	80	19	figure	figure	NOUN
admet-657	80	20	3	3	NUM
admet-657	80	21	.	.	PUNCT
admet-657	80	22	effect	effect	NOUN
admet-657	80	23	of	of	ADP
admet-657	80	24	ph	ph	PROPN
admet-657	80	25	on	on	ADP
admet-657	80	26	pampa	pampa	PROPN
admet-657	80	27	permeation	permeation	NOUN
admet-657	80	28	of	of	ADP
admet-657	80	29	tetracycline	tetracycline	NOUN
admet-657	80	30	(	(	PUNCT
admet-657	80	31	mean	mean	PROPN
admet-657	80	32	±	±	NUM
admet-657	80	33	sd	sd	NOUN
admet-657	80	34	,	,	PUNCT
admet-657	80	35	n	n	NOUN
admet-657	80	36	=	=	SYM
admet-657	80	37	3	3	NUM
admet-657	80	38	)	)	PUNCT
admet-657	80	39	.	.	PUNCT
admet-657	81	1	assay	assay	NOUN
admet-657	81	2	conditions	condition	NOUN
admet-657	81	3	:	:	PUNCT
admet-657	81	4	tc	tc	NUM
admet-657	81	5	0.5	0.5	NUM
admet-657	81	6	mm	mm	NOUN
admet-657	81	7	,	,	PUNCT
admet-657	81	8	10	10	NUM
admet-657	81	9	%	%	NOUN
admet-657	81	10	spl	spl	PROPN
admet-657	81	11	-	-	PUNCT
admet-657	81	12	white	white	ADJ
admet-657	81	13	/	/	SYM
admet-657	81	14	decane	decane	NOUN
admet-657	81	15	,	,	PUNCT
admet-657	81	16	50	50	NUM
admet-657	81	17	mm	mm	NUM
admet-657	81	18	sodium	sodium	NOUN
admet-657	81	19	phosphate	phosphate	NOUN
admet-657	81	20	buffer	buffer	NOUN
admet-657	81	21	,	,	PUNCT
admet-657	81	22	at	at	ADP
admet-657	81	23	37	37	NUM
admet-657	81	24	°	°	NOUN
admet-657	81	25	c	c	NOUN
admet-657	81	26	.	.	PUNCT
admet-657	82	1	figure	figure	NOUN
admet-657	82	2	4	4	NUM
admet-657	82	3	.	.	PUNCT
admet-657	82	4	effect	effect	NOUN
admet-657	82	5	of	of	ADP
admet-657	82	6	ionic	ionic	ADJ
admet-657	82	7	strength	strength	NOUN
admet-657	82	8	on	on	ADP
admet-657	82	9	pampa	pampa	PROPN
admet-657	82	10	permeation	permeation	NOUN
admet-657	82	11	of	of	ADP
admet-657	82	12	tetracycline	tetracycline	NOUN
admet-657	82	13	(	(	PUNCT
admet-657	82	14	mean	mean	PROPN
admet-657	82	15	±	±	NUM
admet-657	82	16	sd	sd	NOUN
admet-657	82	17	,	,	PUNCT
admet-657	82	18	n	n	NOUN
admet-657	82	19	=	=	SYM
admet-657	82	20	3	3	NUM
admet-657	82	21	)	)	PUNCT
admet-657	82	22	.	.	PUNCT
admet-657	83	1	assay	assay	NOUN
admet-657	83	2	conditions	condition	NOUN
admet-657	83	3	:	:	PUNCT
admet-657	83	4	tc	tc	NUM
admet-657	83	5	0.5	0.5	NUM
admet-657	83	6	mm	mm	NOUN
admet-657	83	7	,	,	PUNCT
admet-657	83	8	10	10	NUM
admet-657	83	9	%	%	NOUN
admet-657	83	10	spl	spl	PROPN
admet-657	83	11	-	-	PUNCT
admet-657	83	12	white	white	ADJ
admet-657	83	13	/	/	SYM
admet-657	83	14	decane	decane	NOUN
admet-657	83	15	,	,	PUNCT
admet-657	83	16	ph	ph	X
admet-657	83	17	6.5	6.5	NUM
admet-657	83	18	,	,	PUNCT
admet-657	83	19	37	37	NUM
admet-657	83	20	°	°	NOUN
admet-657	83	21	c	c	X
admet-657	83	22	.	.	PUNCT
admet-657	84	1	the	the	DET
admet-657	84	2	ionic	ionic	ADJ
admet-657	84	3	strength	strength	NOUN
admet-657	84	4	of	of	ADP
admet-657	84	5	the	the	DET
admet-657	84	6	medium	medium	NOUN
admet-657	84	7	was	be	AUX
admet-657	84	8	adjusted	adjust	VERB
admet-657	84	9	by	by	ADP
admet-657	84	10	nacl	nacl	NOUN
admet-657	84	11	.	.	PUNCT
admet-657	85	1	yamauchi	yamauchi	NOUN
admet-657	85	2	and	and	CCONJ
admet-657	85	3	sugano	sugano	VERB
admet-657	85	4	admet	admet	PROPN
admet-657	85	5	&	&	CCONJ
admet-657	85	6	dmpk	dmpk	PROPN
admet-657	85	7	7(3	7(3	NUM
admet-657	85	8	)	)	PUNCT
admet-657	85	9	(	(	PUNCT
admet-657	85	10	2019	2019	NUM
admet-657	85	11	)	)	PUNCT
admet-657	85	12	151	151	NUM
admet-657	85	13	-	-	SYM
admet-657	85	14	160	160	NUM
admet-657	85	15	156	156	NUM
admet-657	85	16	temperature	temperature	NOUN
admet-657	85	17	dependence	dependence	NOUN
admet-657	85	18	the	the	DET
admet-657	85	19	effect	effect	NOUN
admet-657	85	20	of	of	ADP
admet-657	85	21	temperature	temperature	NOUN
admet-657	85	22	on	on	ADP
admet-657	85	23	the	the	DET
admet-657	85	24	pampa	pampa	PROPN
admet-657	85	25	permeation	permeation	NOUN
admet-657	85	26	of	of	ADP
admet-657	85	27	tc	tc	NOUN
admet-657	85	28	is	be	AUX
admet-657	85	29	shown	show	VERB
admet-657	85	30	in	in	ADP
admet-657	85	31	figure	figure	NOUN
admet-657	85	32	5	5	NUM
admet-657	85	33	.	.	PUNCT
admet-657	86	1	as	as	SCONJ
admet-657	86	2	the	the	DET
admet-657	86	3	temperature	temperature	NOUN
admet-657	86	4	was	be	AUX
admet-657	86	5	increased	increase	VERB
admet-657	86	6	from	from	ADP
admet-657	86	7	15	15	NUM
admet-657	86	8	°	°	NOUN
admet-657	86	9	c	c	NOUN
admet-657	86	10	to	to	ADP
admet-657	86	11	37	37	NUM
admet-657	86	12	°	°	NOUN
admet-657	86	13	c	c	NOUN
admet-657	86	14	,	,	PUNCT
admet-657	86	15	the	the	DET
admet-657	86	16	pe	pe	PROPN
admet-657	86	17	value	value	NOUN
admet-657	86	18	was	be	AUX
admet-657	86	19	increased	increase	VERB
admet-657	86	20	6.5	6.5	NUM
admet-657	86	21	fold	fold	NOUN
admet-657	86	22	.	.	PUNCT
admet-657	87	1	figure	figure	NOUN
admet-657	87	2	5	5	NUM
admet-657	87	3	.	.	PUNCT
admet-657	87	4	effect	effect	NOUN
admet-657	87	5	of	of	ADP
admet-657	87	6	temperature	temperature	NOUN
admet-657	87	7	on	on	ADP
admet-657	87	8	pampa	pampa	PROPN
admet-657	87	9	permeation	permeation	NOUN
admet-657	87	10	of	of	ADP
admet-657	87	11	tetracycline	tetracycline	NOUN
admet-657	87	12	(	(	PUNCT
admet-657	87	13	mean	mean	PROPN
admet-657	87	14	±	±	NUM
admet-657	87	15	sd	sd	NOUN
admet-657	87	16	,	,	PUNCT
admet-657	87	17	n	n	NOUN
admet-657	87	18	=	=	SYM
admet-657	87	19	3	3	NUM
admet-657	87	20	)	)	PUNCT
admet-657	87	21	.	.	PUNCT
admet-657	88	1	assay	assay	NOUN
admet-657	88	2	conditions	condition	NOUN
admet-657	88	3	:	:	PUNCT
admet-657	88	4	tc	tc	NUM
admet-657	88	5	0.5	0.5	NUM
admet-657	88	6	mm	mm	NOUN
admet-657	88	7	,	,	PUNCT
admet-657	88	8	10	10	NUM
admet-657	88	9	%	%	NOUN
admet-657	88	10	spl	spl	PROPN
admet-657	88	11	-	-	PUNCT
admet-657	88	12	white	white	ADJ
admet-657	88	13	/	/	SYM
admet-657	88	14	decane	decane	NOUN
admet-657	88	15	,	,	PUNCT
admet-657	88	16	ph	ph	X
admet-657	88	17	6.5	6.5	NUM
admet-657	88	18	50	50	NUM
admet-657	88	19	mm	mm	NUM
admet-657	88	20	sodium	sodium	NOUN
admet-657	88	21	phosphate	phosphate	NOUN
admet-657	88	22	buffer	buffer	NOUN
admet-657	88	23	.	.	PUNCT
admet-657	89	1	concentration	concentration	NOUN
admet-657	89	2	dependence	dependence	NOUN
admet-657	89	3	the	the	DET
admet-657	89	4	effect	effect	NOUN
admet-657	89	5	of	of	ADP
admet-657	89	6	tc	tc	NOUN
admet-657	89	7	concentration	concentration	NOUN
admet-657	89	8	on	on	ADP
admet-657	89	9	the	the	DET
admet-657	89	10	pampa	pampa	PROPN
admet-657	89	11	permeation	permeation	NOUN
admet-657	89	12	is	be	AUX
admet-657	89	13	shown	show	VERB
admet-657	89	14	in	in	ADP
admet-657	89	15	figure	figure	NOUN
admet-657	89	16	6	6	NUM
admet-657	89	17	.	.	PUNCT
admet-657	90	1	the	the	DET
admet-657	90	2	pe	pe	PROPN
admet-657	90	3	value	value	NOUN
admet-657	90	4	of	of	ADP
admet-657	90	5	tc	tc	PRON
admet-657	90	6	was	be	AUX
admet-657	90	7	not	not	PART
admet-657	90	8	affected	affect	VERB
admet-657	90	9	by	by	ADP
admet-657	90	10	the	the	DET
admet-657	90	11	tc	tc	NOUN
admet-657	90	12	concentration	concentration	NOUN
admet-657	90	13	up	up	ADP
admet-657	90	14	to	to	PART
admet-657	90	15	0.5	0.5	NUM
admet-657	90	16	mm	mm	NOUN
admet-657	90	17	.	.	PUNCT
admet-657	91	1	due	due	ADP
admet-657	91	2	to	to	ADP
admet-657	91	3	the	the	DET
admet-657	91	4	solubility	solubility	NOUN
admet-657	91	5	of	of	ADP
admet-657	91	6	tc	tc	NOUN
admet-657	91	7	in	in	ADP
admet-657	91	8	the	the	DET
admet-657	91	9	medium	medium	NOUN
admet-657	91	10	,	,	PUNCT
admet-657	91	11	the	the	DET
admet-657	91	12	concentration	concentration	NOUN
admet-657	91	13	of	of	ADP
admet-657	91	14	tc	tc	PRON
admet-657	91	15	could	could	AUX
admet-657	91	16	not	not	PART
admet-657	91	17	be	be	AUX
admet-657	91	18	increased	increase	VERB
admet-657	91	19	above	above	ADP
admet-657	91	20	0.5	0.5	NUM
admet-657	91	21	mm	mm	NOUN
admet-657	91	22	.	.	PUNCT
admet-657	92	1	figure	figure	NOUN
admet-657	92	2	6	6	NUM
admet-657	92	3	.	.	PUNCT
admet-657	93	1	effect	effect	NOUN
admet-657	93	2	of	of	ADP
admet-657	93	3	tetracycline	tetracycline	ADJ
admet-657	93	4	concentration	concentration	NOUN
admet-657	93	5	on	on	ADP
admet-657	93	6	pampa	pampa	PROPN
admet-657	93	7	permeation	permeation	NOUN
admet-657	93	8	(	(	PUNCT
admet-657	93	9	mean	mean	PROPN
admet-657	93	10	±	±	NUM
admet-657	93	11	sd	sd	NOUN
admet-657	93	12	,	,	PUNCT
admet-657	93	13	n	n	NOUN
admet-657	93	14	=	=	SYM
admet-657	93	15	3	3	NUM
admet-657	93	16	)	)	PUNCT
admet-657	93	17	.	.	PUNCT
admet-657	94	1	assay	assay	NOUN
admet-657	94	2	conditions	condition	NOUN
admet-657	94	3	:	:	PUNCT
admet-657	94	4	10	10	NUM
admet-657	94	5	%	%	NOUN
admet-657	94	6	spl	spl	PROPN
admet-657	94	7	-	-	PUNCT
admet-657	94	8	white	white	ADJ
admet-657	94	9	/	/	SYM
admet-657	94	10	decane	decane	NOUN
admet-657	94	11	,	,	PUNCT
admet-657	94	12	ph	ph	X
admet-657	94	13	6.5	6.5	NUM
admet-657	94	14	50	50	NUM
admet-657	94	15	mm	mm	NUM
admet-657	94	16	sodium	sodium	NOUN
admet-657	94	17	phosphate	phosphate	NOUN
admet-657	94	18	buffer	buffer	NOUN
admet-657	94	19	,	,	PUNCT
admet-657	94	20	37	37	NUM
admet-657	94	21	°	°	NOUN
admet-657	94	22	c	c	X
admet-657	94	23	.	.	PUNCT
admet-657	95	1	admet	admet	PROPN
admet-657	95	2	&	&	CCONJ
admet-657	95	3	dmpk	dmpk	PROPN
admet-657	95	4	7(3	7(3	NUM
admet-657	95	5	)	)	PUNCT
admet-657	95	6	(	(	PUNCT
admet-657	95	7	2019	2019	NUM
admet-657	95	8	)	)	PUNCT
admet-657	95	9	151	151	NUM
admet-657	95	10	-	-	SYM
admet-657	95	11	160	160	NUM
admet-657	95	12	permeation	permeation	NOUN
admet-657	95	13	characteristics	characteristic	NOUN
admet-657	95	14	of	of	ADP
admet-657	95	15	tetracyclines	tetracyclines	PROPN
admet-657	95	16	in	in	ADP
admet-657	95	17	pampa	pampa	PROPN
admet-657	95	18	doi	doi	PROPN
admet-657	95	19	:	:	PUNCT
admet-657	95	20	10.5599	10.5599	NUM
admet-657	95	21	/	/	SYM
admet-657	95	22	admet.657	admet.657	PROPN
admet-657	95	23	157	157	NUM
admet-657	95	24	effect	effect	NOUN
admet-657	95	25	of	of	ADP
admet-657	95	26	additives	additive	NOUN
admet-657	95	27	in	in	ADP
admet-657	95	28	the	the	DET
admet-657	95	29	donor	donor	NOUN
admet-657	95	30	media	medium	NOUN
admet-657	95	31	the	the	DET
admet-657	95	32	effect	effect	NOUN
admet-657	95	33	of	of	ADP
admet-657	95	34	possible	possible	ADJ
admet-657	95	35	inhibitors	inhibitor	NOUN
admet-657	95	36	on	on	ADP
admet-657	95	37	the	the	DET
admet-657	95	38	pampa	pampa	PROPN
admet-657	95	39	permeation	permeation	NOUN
admet-657	95	40	of	of	ADP
admet-657	95	41	tc	tc	NOUN
admet-657	95	42	is	be	AUX
admet-657	95	43	shown	show	VERB
admet-657	95	44	in	in	ADP
admet-657	95	45	figure	figure	NOUN
admet-657	95	46	7	7	NUM
admet-657	95	47	.	.	X
admet-657	95	48	procainamide	procainamide	PROPN
admet-657	95	49	was	be	AUX
admet-657	95	50	used	use	VERB
admet-657	95	51	as	as	ADP
admet-657	95	52	a	a	DET
admet-657	95	53	control	control	NOUN
admet-657	95	54	of	of	ADP
admet-657	95	55	the	the	DET
admet-657	95	56	ion	ion	NOUN
admet-657	95	57	-	-	PUNCT
admet-657	95	58	pair	pair	NOUN
admet-657	95	59	transport	transport	NOUN
admet-657	95	60	(	(	PUNCT
admet-657	95	61	a	a	DET
admet-657	95	62	cation	cation	NOUN
admet-657	95	63	drug	drug	NOUN
admet-657	95	64	and	and	CCONJ
admet-657	95	65	an	an	DET
admet-657	95	66	anion	anion	NOUN
admet-657	95	67	phospholipid	phospholipid	NOUN
admet-657	95	68	)	)	PUNCT
admet-657	95	69	.	.	PUNCT
admet-657	96	1	the	the	DET
admet-657	96	2	permeation	permeation	NOUN
admet-657	96	3	of	of	ADP
admet-657	96	4	procainamide	procainamide	NOUN
admet-657	96	5	was	be	AUX
admet-657	96	6	inhibited	inhibit	VERB
admet-657	96	7	by	by	ADP
admet-657	96	8	tetrahexylammonium	tetrahexylammonium	NOUN
admet-657	96	9	(	(	PUNCT
admet-657	96	10	tha	tha	NOUN
admet-657	96	11	)	)	PUNCT
admet-657	96	12	,	,	PUNCT
admet-657	96	13	however	however	ADV
admet-657	96	14	not	not	PART
admet-657	96	15	by	by	ADP
admet-657	96	16	l	l	NOUN
admet-657	96	17	-	-	NOUN
admet-657	96	18	leucine	leucine	NOUN
admet-657	96	19	and	and	CCONJ
admet-657	96	20	2	2	NUM
admet-657	96	21	-	-	PUNCT
admet-657	96	22	amino	amino	ADJ
admet-657	96	23	octanoic	octanoic	ADJ
admet-657	96	24	acid	acid	NOUN
admet-657	96	25	(	(	PUNCT
admet-657	96	26	aoa	aoa	PROPN
admet-657	96	27	)	)	PUNCT
admet-657	96	28	.	.	PUNCT
admet-657	97	1	the	the	DET
admet-657	97	2	permeation	permeation	NOUN
admet-657	97	3	of	of	ADP
admet-657	97	4	tc	tc	PRON
admet-657	97	5	was	be	AUX
admet-657	97	6	not	not	PART
admet-657	97	7	inhibited	inhibit	VERB
admet-657	97	8	by	by	ADP
admet-657	97	9	the	the	DET
admet-657	97	10	inhibitors	inhibitor	NOUN
admet-657	97	11	employed	employ	VERB
admet-657	97	12	in	in	ADP
admet-657	97	13	this	this	DET
admet-657	97	14	study	study	NOUN
admet-657	97	15	.	.	PUNCT
admet-657	98	1	figure	figure	NOUN
admet-657	98	2	7	7	NUM
admet-657	98	3	.	.	PUNCT
admet-657	98	4	effect	effect	NOUN
admet-657	98	5	of	of	ADP
admet-657	98	6	additives	additive	NOUN
admet-657	98	7	on	on	ADP
admet-657	98	8	pampa	pampa	PROPN
admet-657	98	9	permeation	permeation	NOUN
admet-657	98	10	of	of	ADP
admet-657	98	11	tetracycline	tetracycline	NOUN
admet-657	98	12	and	and	CCONJ
admet-657	98	13	procainamide	procainamide	NOUN
admet-657	98	14	(	(	PUNCT
admet-657	98	15	mean	mean	PROPN
admet-657	98	16	±	±	NUM
admet-657	98	17	sd	sd	NOUN
admet-657	98	18	,	,	PUNCT
admet-657	98	19	n	n	NOUN
admet-657	98	20	=	=	SYM
admet-657	98	21	3	3	NUM
admet-657	98	22	)	)	PUNCT
admet-657	98	23	.	.	PUNCT
admet-657	99	1	assay	assay	NOUN
admet-657	99	2	conditions	condition	NOUN
admet-657	99	3	:	:	PUNCT
admet-657	99	4	substrates	substrate	VERB
admet-657	99	5	0.5	0.5	NUM
admet-657	99	6	mm	mm	NOUN
admet-657	99	7	,	,	PUNCT
admet-657	99	8	additives	additive	VERB
admet-657	99	9	10	10	NUM
admet-657	99	10	mm	mm	NOUN
admet-657	99	11	,	,	PUNCT
admet-657	99	12	10	10	NUM
admet-657	99	13	%	%	NOUN
admet-657	99	14	spl	spl	PROPN
admet-657	99	15	-	-	PUNCT
admet-657	99	16	white	white	ADJ
admet-657	99	17	/	/	SYM
admet-657	99	18	decane	decane	NOUN
admet-657	99	19	,	,	PUNCT
admet-657	99	20	ph	ph	X
admet-657	99	21	6.5	6.5	NUM
admet-657	99	22	50	50	NUM
admet-657	99	23	mm	mm	NUM
admet-657	99	24	sodium	sodium	NOUN
admet-657	99	25	phosphate	phosphate	NOUN
admet-657	99	26	buffer	buffer	NOUN
admet-657	99	27	,	,	PUNCT
admet-657	99	28	37	37	NUM
admet-657	99	29	°	°	NOUN
admet-657	99	30	c	c	X
admet-657	99	31	.	.	PUNCT
admet-657	100	1	log	log	VERB
admet-657	100	2	pe	pe	PROPN
admet-657	100	3	–	–	PUNCT
admet-657	100	4	log	log	NOUN
admet-657	100	5	d	d	NOUN
admet-657	100	6	relationship	relationship	NOUN
admet-657	100	7	the	the	DET
admet-657	100	8	log	log	NOUN
admet-657	100	9	pe	pe	INTJ
admet-657	100	10	–	–	PUNCT
admet-657	100	11	log	log	NOUN
admet-657	100	12	d	d	NOUN
admet-657	100	13	relationship	relationship	NOUN
admet-657	100	14	for	for	ADP
admet-657	100	15	tetracyclines	tetracycline	NOUN
admet-657	100	16	is	be	AUX
admet-657	100	17	shown	show	VERB
admet-657	100	18	in	in	ADP
admet-657	100	19	table	table	NOUN
admet-657	100	20	3	3	NUM
admet-657	100	21	and	and	CCONJ
admet-657	100	22	figure	figure	VERB
admet-657	100	23	8	8	NUM
admet-657	100	24	.	.	PUNCT
admet-657	101	1	a	a	DET
admet-657	101	2	weak	weak	ADJ
admet-657	101	3	correlation	correlation	NOUN
admet-657	101	4	was	be	AUX
admet-657	101	5	observed	observe	VERB
admet-657	101	6	between	between	ADP
admet-657	101	7	log	log	NOUN
admet-657	101	8	pe	pe	PROPN
admet-657	101	9	and	and	CCONJ
admet-657	101	10	log	log	VERB
admet-657	101	11	d.	d.	PROPN
admet-657	101	12	table	table	NOUN
admet-657	101	13	3	3	PROPN
admet-657	101	14	.	.	PUNCT
admet-657	101	15	pampa	pampa	NOUN
admet-657	101	16	permeability	permeability	NOUN
admet-657	101	17	for	for	ADP
admet-657	101	18	tetracyclines	tetracycline	NOUN
admet-657	101	19	a	a	DET
admet-657	101	20	pe	pe	PROPN
admet-657	101	21	(	(	PUNCT
admet-657	101	22	10	10	NUM
admet-657	101	23	-	-	SYM
admet-657	101	24	6	6	NUM
admet-657	101	25	cm	cm	NOUN
admet-657	101	26	/	/	SYM
admet-657	101	27	sec	sec	PROPN
admet-657	101	28	,	,	PUNCT
admet-657	101	29	mean	mean	VERB
admet-657	101	30	±	±	NUM
admet-657	101	31	sd	sd	NOUN
admet-657	101	32	,	,	PUNCT
admet-657	101	33	n	n	NOUN
admet-657	101	34	=	=	SYM
admet-657	101	35	6	6	NUM
admet-657	101	36	)	)	PUNCT
admet-657	101	37	chlortetracycline	chlortetracycline	VERB
admet-657	101	38	41	41	NUM
admet-657	101	39	±	±	NUM
admet-657	101	40	3	3	NUM
admet-657	101	41	demeclocycline	demeclocycline	NOUN
admet-657	101	42	33	33	NUM
admet-657	101	43	±	±	NUM
admet-657	101	44	1	1	NUM
admet-657	101	45	doxycycline	doxycycline	NOUN
admet-657	101	46	64	64	NUM
admet-657	101	47	±	±	NUM
admet-657	101	48	5	5	NUM
admet-657	101	49	minocycline	minocycline	NOUN
admet-657	101	50	71	71	NUM
admet-657	101	51	±	±	NUM
admet-657	101	52	6	6	NUM
admet-657	101	53	oxytetracycline	oxytetracycline	NOUN
admet-657	101	54	9.2	9.2	NUM
admet-657	101	55	±	±	NUM
admet-657	101	56	0.7	0.7	NUM
admet-657	101	57	tetracycline	tetracycline	NOUN
admet-657	101	58	15	15	NUM
admet-657	101	59	±	±	NUM
admet-657	101	60	1	1	NUM
admet-657	101	61	a	a	DET
admet-657	101	62	tetracyclines	tetracycline	NOUN
admet-657	101	63	0.5	0.5	NUM
admet-657	101	64	mm	mm	PROPN
admet-657	101	65	,	,	PUNCT
admet-657	101	66	10	10	NUM
admet-657	101	67	%	%	NOUN
admet-657	101	68	spl	spl	NOUN
admet-657	101	69	-	-	PUNCT
admet-657	101	70	white	white	ADJ
admet-657	101	71	/	/	SYM
admet-657	101	72	decane	decane	NOUN
admet-657	101	73	,	,	PUNCT
admet-657	101	74	ph	ph	X
admet-657	101	75	6.5	6.5	NUM
admet-657	101	76	50	50	NUM
admet-657	101	77	mm	mm	NUM
admet-657	101	78	sodium	sodium	NOUN
admet-657	101	79	phosphate	phosphate	NOUN
admet-657	101	80	buffer	buffer	NOUN
admet-657	101	81	,	,	PUNCT
admet-657	101	82	37	37	NUM
admet-657	101	83	°	°	NOUN
admet-657	101	84	c	c	NOUN
admet-657	101	85	.	.	PUNCT
admet-657	102	1	discussion	discussion	NOUN
admet-657	102	2	we	we	PRON
admet-657	102	3	first	first	ADV
admet-657	102	4	investigated	investigate	VERB
admet-657	102	5	the	the	DET
admet-657	102	6	effect	effect	NOUN
admet-657	102	7	of	of	ADP
admet-657	102	8	the	the	DET
admet-657	102	9	membrane	membrane	NOUN
admet-657	102	10	composition	composition	NOUN
admet-657	102	11	on	on	ADP
admet-657	102	12	the	the	DET
admet-657	102	13	pampa	pampa	PROPN
admet-657	102	14	permeation	permeation	NOUN
admet-657	102	15	of	of	ADP
admet-657	102	16	tc	tc	NOUN
admet-657	102	17	.	.	PUNCT
admet-657	103	1	the	the	DET
admet-657	103	2	results	result	NOUN
admet-657	103	3	of	of	ADP
admet-657	103	4	the	the	DET
admet-657	103	5	lipid	lipid	NOUN
admet-657	103	6	composition	composition	NOUN
admet-657	103	7	dependency	dependency	NOUN
admet-657	103	8	study	study	NOUN
admet-657	103	9	suggest	suggest	VERB
admet-657	103	10	that	that	SCONJ
admet-657	103	11	intermolecular	intermolecular	ADJ
admet-657	103	12	interactions	interaction	NOUN
admet-657	103	13	between	between	ADP
admet-657	103	14	tc	tc	NOUN
admet-657	103	15	and	and	CCONJ
admet-657	103	16	pe	pe	INTJ
admet-657	103	17	,	,	PUNCT
admet-657	103	18	ps	ps	PROPN
admet-657	103	19	and/or	and/or	CCONJ
admet-657	103	20	pi	pi	PROPN
admet-657	103	21	facilitate	facilitate	VERB
admet-657	103	22	the	the	DET
admet-657	103	23	passive	passive	ADJ
admet-657	103	24	diffusion	diffusion	NOUN
admet-657	103	25	of	of	ADP
admet-657	103	26	tc	tc	NOUN
admet-657	103	27	across	across	ADP
admet-657	103	28	the	the	DET
admet-657	103	29	pampa	pampa	NOUN
admet-657	103	30	membrane	membrane	NOUN
admet-657	103	31	[	[	X
admet-657	103	32	20	20	NUM
admet-657	103	33	]	]	PUNCT
admet-657	103	34	.	.	PUNCT
admet-657	104	1	the	the	DET
admet-657	104	2	results	result	NOUN
admet-657	104	3	of	of	ADP
admet-657	104	4	this	this	DET
admet-657	104	5	study	study	NOUN
admet-657	104	6	are	be	AUX
admet-657	104	7	in	in	ADP
admet-657	104	8	good	good	ADJ
admet-657	104	9	agreement	agreement	NOUN
admet-657	104	10	with	with	ADP
admet-657	104	11	the	the	DET
admet-657	104	12	previous	previous	ADJ
admet-657	104	13	finding	finding	NOUN
admet-657	104	14	that	that	SCONJ
admet-657	104	15	the	the	DET
admet-657	104	16	lipid	lipid	NOUN
admet-657	104	17	composition	composition	NOUN
admet-657	104	18	is	be	AUX
admet-657	104	19	critically	critically	ADV
admet-657	104	20	important	important	ADJ
admet-657	104	21	for	for	SCONJ
admet-657	104	22	the	the	DET
admet-657	104	23	pampa	pampa	PROPN
admet-657	104	24	assay	assay	VERB
admet-657	104	25	[	[	X
admet-657	104	26	9,21	9,21	NUM
admet-657	104	27	]	]	PUNCT
admet-657	104	28	.	.	PUNCT
admet-657	105	1	the	the	DET
admet-657	105	2	pe	pe	PROPN
admet-657	105	3	value	value	NOUN
admet-657	105	4	of	of	ADP
admet-657	105	5	tc	tc	NUM
admet-657	105	6	in	in	ADP
admet-657	105	7	the	the	DET
admet-657	105	8	10	10	NUM
admet-657	105	9	%	%	NOUN
admet-657	105	10	soybean	soybean	NOUN
admet-657	105	11	lecithin	lecithin	NOUN
admet-657	105	12	/	/	SYM
admet-657	105	13	decane	decane	NOUN
admet-657	105	14	membrane	membrane	NOUN
admet-657	105	15	was	be	AUX
admet-657	105	16	similar	similar	ADJ
admet-657	105	17	to	to	ADP
admet-657	105	18	that	that	PRON
admet-657	105	19	observed	observe	VERB
admet-657	105	20	in	in	ADP
admet-657	105	21	the	the	DET
admet-657	105	22	biomimetic	biomimetic	ADJ
admet-657	105	23	pampa	pampa	NOUN
admet-657	105	24	in	in	ADP
admet-657	105	25	which	which	PRON
admet-657	105	26	1,7	1,7	NUM
admet-657	105	27	-	-	PUNCT
admet-657	105	28	octadiene	octadiene	NOUN
admet-657	105	29	was	be	AUX
admet-657	105	30	used	use	VERB
admet-657	105	31	as	as	ADP
admet-657	105	32	an	an	DET
admet-657	105	33	organic	organic	ADJ
admet-657	105	34	solvent	solvent	NOUN
admet-657	105	35	.	.	PUNCT
admet-657	106	1	even	even	ADV
admet-657	106	2	though	though	SCONJ
admet-657	106	3	the	the	DET
admet-657	106	4	biomimetic	biomimetic	ADJ
admet-657	106	5	pampa	pampa	PROPN
admet-657	106	6	showed	show	VERB
admet-657	106	7	promising	promising	ADJ
admet-657	106	8	predictability	predictability	NOUN
admet-657	106	9	for	for	ADP
admet-657	106	10	in	in	ADP
admet-657	106	11	vivo	vivo	ADJ
admet-657	106	12	oral	oral	ADJ
admet-657	106	13	drug	drug	NOUN
admet-657	106	14	absorption	absorption	NOUN
admet-657	106	15	,	,	PUNCT
admet-657	106	16	as	as	SCONJ
admet-657	106	17	1,7octadiene	1,7octadiene	PROPN
admet-657	106	18	is	be	AUX
admet-657	106	19	irritant	irritant	ADJ
admet-657	106	20	,	,	PUNCT
admet-657	106	21	it	it	PRON
admet-657	106	22	is	be	AUX
admet-657	106	23	not	not	PART
admet-657	106	24	suitable	suitable	ADJ
admet-657	106	25	for	for	ADP
admet-657	106	26	routing	route	VERB
admet-657	106	27	use	use	NOUN
admet-657	106	28	.	.	PUNCT
admet-657	107	1	yamauchi	yamauchi	NOUN
admet-657	107	2	and	and	CCONJ
admet-657	107	3	sugano	sugano	VERB
admet-657	107	4	admet	admet	PROPN
admet-657	107	5	&	&	CCONJ
admet-657	107	6	dmpk	dmpk	PROPN
admet-657	107	7	7(3	7(3	NUM
admet-657	107	8	)	)	PUNCT
admet-657	107	9	(	(	PUNCT
admet-657	107	10	2019	2019	NUM
admet-657	107	11	)	)	PUNCT
admet-657	107	12	151	151	NUM
admet-657	107	13	-	-	SYM
admet-657	107	14	160	160	NUM
admet-657	107	15	158	158	NUM
admet-657	107	16	figure	figure	NOUN
admet-657	107	17	8	8	NUM
admet-657	107	18	.	.	PUNCT
admet-657	107	19	correlation	correlation	NOUN
admet-657	107	20	between	between	ADP
admet-657	107	21	log	log	PROPN
admet-657	107	22	d	d	NOUN
admet-657	107	23	and	and	CCONJ
admet-657	107	24	pampa	pampa	PROPN
admet-657	107	25	permeability	permeability	NOUN
admet-657	107	26	for	for	ADP
admet-657	107	27	tetracyclines	tetracycline	NOUN
admet-657	107	28	(	(	PUNCT
admet-657	107	29	mean	mean	PROPN
admet-657	107	30	±	±	NUM
admet-657	107	31	sd	sd	NOUN
admet-657	107	32	,	,	PUNCT
admet-657	107	33	n	n	NOUN
admet-657	107	34	=	=	NUM
admet-657	107	35	6	6	NUM
admet-657	107	36	)	)	PUNCT
admet-657	107	37	.	.	PUNCT
admet-657	108	1	pampa	pampa	PROPN
admet-657	108	2	conditions	condition	NOUN
admet-657	108	3	:	:	PUNCT
admet-657	108	4	tetracyclines	tetracycline	NOUN
admet-657	108	5	0.5	0.5	NUM
admet-657	108	6	mm	mm	PROPN
admet-657	108	7	,	,	PUNCT
admet-657	108	8	10	10	NUM
admet-657	108	9	%	%	NOUN
admet-657	108	10	spl	spl	PROPN
admet-657	108	11	-	-	PUNCT
admet-657	108	12	white	white	ADJ
admet-657	108	13	/	/	SYM
admet-657	108	14	decane	decane	NOUN
admet-657	108	15	,	,	PUNCT
admet-657	108	16	ph	ph	X
admet-657	108	17	6.5	6.5	NUM
admet-657	108	18	50	50	NUM
admet-657	108	19	mm	mm	NUM
admet-657	108	20	sodium	sodium	NOUN
admet-657	108	21	phosphate	phosphate	NOUN
admet-657	108	22	buffer	buffer	NOUN
admet-657	108	23	,	,	PUNCT
admet-657	108	24	37	37	NUM
admet-657	108	25	°	°	NOUN
admet-657	108	26	c	c	NOUN
admet-657	108	27	.	.	PUNCT
admet-657	109	1	tc	tc	PRON
admet-657	109	2	predominantly	predominantly	ADV
admet-657	109	3	exists	exist	VERB
admet-657	109	4	as	as	ADP
admet-657	109	5	zwitterion	zwitterion	NOUN
admet-657	109	6	form	form	NOUN
admet-657	109	7	(	(	PUNCT
admet-657	109	8	net	net	ADJ
admet-657	109	9	zero	zero	NUM
admet-657	109	10	charge	charge	NOUN
admet-657	109	11	)	)	PUNCT
admet-657	109	12	in	in	ADP
admet-657	109	13	the	the	DET
admet-657	109	14	range	range	NOUN
admet-657	109	15	of	of	ADP
admet-657	109	16	ph	ph	NOUN
admet-657	109	17	4.0	4.0	NUM
admet-657	109	18	to	to	PART
admet-657	109	19	7.0	7.0	NUM
admet-657	109	20	.	.	PUNCT
admet-657	110	1	in	in	ADP
admet-657	110	2	this	this	DET
admet-657	110	3	ph	ph	ADJ
admet-657	110	4	range	range	NOUN
admet-657	110	5	,	,	PUNCT
admet-657	110	6	the	the	DET
admet-657	110	7	pe	pe	PROPN
admet-657	110	8	value	value	NOUN
admet-657	110	9	remained	remain	VERB
admet-657	110	10	constant	constant	ADJ
admet-657	110	11	.	.	PUNCT
admet-657	111	1	above	above	ADP
admet-657	111	2	ph	ph	PROPN
admet-657	111	3	7.0	7.0	NUM
admet-657	111	4	,	,	PUNCT
admet-657	111	5	the	the	DET
admet-657	111	6	pe	pe	PROPN
admet-657	111	7	value	value	NOUN
admet-657	111	8	decreased	decrease	VERB
admet-657	111	9	as	as	SCONJ
admet-657	111	10	tc	tc	NOUN
admet-657	111	11	becomes	becomes	AUX
admet-657	111	12	negatively	negatively	ADV
admet-657	111	13	charged	charge	VERB
admet-657	111	14	(	(	PUNCT
admet-657	111	15	two	two	NUM
admet-657	111	16	anions	anion	NOUN
admet-657	111	17	and	and	CCONJ
admet-657	111	18	one	one	NUM
admet-657	111	19	cation	cation	NOUN
admet-657	111	20	)	)	PUNCT
admet-657	111	21	due	due	ADP
admet-657	111	22	to	to	ADP
admet-657	111	23	the	the	DET
admet-657	111	24	dissociation	dissociation	NOUN
admet-657	111	25	of	of	ADP
admet-657	111	26	the	the	DET
admet-657	111	27	phenolic	phenolic	ADJ
admet-657	111	28	diketone	diketone	NOUN
admet-657	111	29	part	part	NOUN
admet-657	111	30	above	above	ADP
admet-657	111	31	ph	ph	PROPN
admet-657	111	32	7.0	7.0	NUM
admet-657	111	33	(	(	PUNCT
admet-657	111	34	figure	figure	NOUN
admet-657	111	35	1	1	NUM
admet-657	111	36	)	)	PUNCT
admet-657	112	1	[	[	X
admet-657	112	2	22	22	NUM
admet-657	112	3	]	]	PUNCT
admet-657	112	4	.	.	PUNCT
admet-657	113	1	however	however	ADV
admet-657	113	2	,	,	PUNCT
admet-657	113	3	the	the	DET
admet-657	113	4	inflection	inflection	NOUN
admet-657	113	5	ph	ph	NOUN
admet-657	113	6	point	point	NOUN
admet-657	113	7	was	be	AUX
admet-657	113	8	below	below	ADP
admet-657	113	9	the	the	DET
admet-657	113	10	pka	pka	PROPN
admet-657	113	11	of	of	ADP
admet-657	113	12	tc	tc	NOUN
admet-657	113	13	.	.	PUNCT
admet-657	114	1	in	in	ADP
admet-657	114	2	addition	addition	NOUN
admet-657	114	3	,	,	PUNCT
admet-657	114	4	the	the	DET
admet-657	114	5	slope	slope	NOUN
admet-657	114	6	of	of	ADP
admet-657	114	7	the	the	DET
admet-657	114	8	ph	ph	ADJ
admet-657	114	9	log	log	NOUN
admet-657	114	10	pe	pe	INTJ
admet-657	114	11	line	line	NOUN
admet-657	114	12	above	above	ADP
admet-657	114	13	ph	ph	PROPN
admet-657	114	14	7.0	7.0	NUM
admet-657	114	15	was	be	AUX
admet-657	114	16	about	about	ADP
admet-657	114	17	-0.5	-0.5	NUM
admet-657	114	18	.	.	PUNCT
admet-657	115	1	these	these	PRON
admet-657	115	2	deviate	deviate	VERB
admet-657	115	3	from	from	ADP
admet-657	115	4	the	the	DET
admet-657	115	5	theoretical	theoretical	ADJ
admet-657	115	6	ph	ph	NOUN
admet-657	115	7	–	–	PUNCT
admet-657	115	8	log	log	NOUN
admet-657	115	9	pe	pe	NOUN
admet-657	115	10	curve	curve	NOUN
admet-657	115	11	based	base	VERB
admet-657	115	12	on	on	ADP
admet-657	115	13	the	the	DET
admet-657	115	14	ph	ph	ADJ
admet-657	115	15	partition	partition	NOUN
admet-657	115	16	theory	theory	NOUN
admet-657	115	17	.	.	PUNCT
admet-657	116	1	further	further	ADJ
admet-657	116	2	investigation	investigation	NOUN
admet-657	116	3	is	be	AUX
admet-657	116	4	required	require	VERB
admet-657	116	5	to	to	PART
admet-657	116	6	clarify	clarify	VERB
admet-657	116	7	the	the	DET
admet-657	116	8	reasons	reason	NOUN
admet-657	116	9	for	for	ADP
admet-657	116	10	these	these	DET
admet-657	116	11	deviations	deviation	NOUN
admet-657	116	12	.	.	PUNCT
admet-657	117	1	ionic	ionic	ADJ
admet-657	117	2	strength	strength	NOUN
admet-657	117	3	had	have	VERB
admet-657	117	4	no	no	DET
admet-657	117	5	effect	effect	NOUN
admet-657	117	6	on	on	ADP
admet-657	117	7	the	the	DET
admet-657	117	8	pe	pe	PROPN
admet-657	117	9	value	value	NOUN
admet-657	117	10	,	,	PUNCT
admet-657	117	11	suggesting	suggest	VERB
admet-657	117	12	that	that	SCONJ
admet-657	117	13	tc	tc	PRON
admet-657	117	14	did	do	AUX
admet-657	117	15	not	not	PART
admet-657	117	16	form	form	VERB
admet-657	117	17	an	an	DET
admet-657	117	18	ion	ion	NOUN
admet-657	117	19	pair	pair	NOUN
admet-657	117	20	with	with	ADP
admet-657	117	21	the	the	DET
admet-657	117	22	inorganic	inorganic	ADJ
admet-657	117	23	ions	ion	NOUN
admet-657	117	24	in	in	ADP
admet-657	117	25	the	the	DET
admet-657	117	26	buffer	buffer	NOUN
admet-657	117	27	at	at	ADP
admet-657	117	28	ph	ph	PROPN
admet-657	117	29	6.5	6.5	NUM
admet-657	117	30	.	.	PUNCT
admet-657	118	1	the	the	DET
admet-657	118	2	pampa	pampa	PROPN
admet-657	118	3	permeation	permeation	NOUN
admet-657	118	4	of	of	ADP
admet-657	118	5	tc	tc	NUM
admet-657	118	6	showed	show	VERB
admet-657	118	7	marked	mark	VERB
admet-657	118	8	temperature	temperature	NOUN
admet-657	118	9	dependence	dependence	NOUN
admet-657	118	10	in	in	ADP
admet-657	118	11	this	this	DET
admet-657	118	12	study	study	NOUN
admet-657	118	13	.	.	PUNCT
admet-657	119	1	the	the	DET
admet-657	119	2	ratio	ratio	NOUN
admet-657	119	3	of	of	ADP
admet-657	119	4	pe	pe	PROPN
admet-657	119	5	values	value	NOUN
admet-657	119	6	between	between	ADP
admet-657	119	7	15	15	NUM
admet-657	119	8	°	°	NOUN
admet-657	119	9	c	c	NOUN
admet-657	119	10	and	and	CCONJ
admet-657	119	11	37	37	NUM
admet-657	119	12	°	°	NOUN
admet-657	119	13	c	c	NOUN
admet-657	119	14	was	be	AUX
admet-657	119	15	6.5	6.5	NUM
admet-657	119	16	.	.	PUNCT
admet-657	120	1	this	this	DET
admet-657	120	2	ratio	ratio	NOUN
admet-657	120	3	was	be	AUX
admet-657	120	4	greater	great	ADJ
admet-657	120	5	than	than	SCONJ
admet-657	120	6	previously	previously	ADV
admet-657	120	7	reported	report	VERB
admet-657	120	8	by	by	ADP
admet-657	120	9	vizserálek	vizserálek	PROPN
admet-657	120	10	et	et	PROPN
admet-657	120	11	al	al	PROPN
admet-657	120	12	.	.	PROPN
admet-657	121	1	for	for	ADP
admet-657	121	2	undissociable	undissociable	ADJ
admet-657	121	3	,	,	PUNCT
admet-657	121	4	mono	mono	NOUN
admet-657	121	5	-	-	PUNCT
admet-657	121	6	acid	acid	ADJ
admet-657	121	7	,	,	PUNCT
admet-657	121	8	and	and	CCONJ
admet-657	121	9	mono	mono	NOUN
admet-657	121	10	-	-	PUNCT
admet-657	121	11	base	base	NOUN
admet-657	121	12	drugs	drug	NOUN
admet-657	121	13	using	use	VERB
admet-657	121	14	the	the	DET
admet-657	121	15	2	2	NUM
admet-657	121	16	%	%	NOUN
admet-657	121	17	pc/1	pc/1	NOUN
admet-657	121	18	%	%	NOUN
admet-657	121	19	cholesterol	cholesterol	NOUN
admet-657	121	20	/	/	SYM
admet-657	121	21	dodecane	dodecane	NOUN
admet-657	121	22	membrane	membrane	NOUN
admet-657	121	23	(	(	PUNCT
admet-657	121	24	1.1	1.1	NUM
admet-657	121	25	to	to	ADP
admet-657	121	26	3.7	3.7	NUM
admet-657	121	27	)	)	PUNCT
admet-657	122	1	[	[	X
admet-657	122	2	23	23	NUM
admet-657	122	3	]	]	PUNCT
admet-657	122	4	.	.	PUNCT
admet-657	123	1	to	to	PART
admet-657	123	2	investigate	investigate	VERB
admet-657	123	3	the	the	DET
admet-657	123	4	permeation	permeation	NOUN
admet-657	123	5	mechanism	mechanism	NOUN
admet-657	123	6	of	of	ADP
admet-657	123	7	tc	tc	NOUN
admet-657	123	8	,	,	PUNCT
admet-657	123	9	the	the	DET
admet-657	123	10	saturation	saturation	NOUN
admet-657	123	11	and	and	CCONJ
admet-657	123	12	inhibition	inhibition	NOUN
admet-657	123	13	of	of	ADP
admet-657	123	14	tc	tc	NOUN
admet-657	123	15	permeation	permeation	NOUN
admet-657	123	16	were	be	AUX
admet-657	123	17	investigated	investigate	VERB
admet-657	123	18	.	.	PUNCT
admet-657	124	1	neither	neither	PRON
admet-657	124	2	saturation	saturation	NOUN
admet-657	124	3	nor	nor	CCONJ
admet-657	124	4	inhibition	inhibition	NOUN
admet-657	124	5	was	be	AUX
admet-657	124	6	observed	observe	VERB
admet-657	124	7	.	.	PUNCT
admet-657	125	1	this	this	DET
admet-657	125	2	result	result	NOUN
admet-657	125	3	was	be	AUX
admet-657	125	4	different	different	ADJ
admet-657	125	5	from	from	ADP
admet-657	125	6	the	the	DET
admet-657	125	7	results	result	NOUN
admet-657	125	8	for	for	ADP
admet-657	125	9	hydrophilic	hydrophilic	ADJ
admet-657	125	10	basic	basic	ADJ
admet-657	125	11	drugs	drug	NOUN
admet-657	125	12	,	,	PUNCT
admet-657	125	13	for	for	ADP
admet-657	125	14	which	which	PRON
admet-657	125	15	both	both	DET
admet-657	125	16	saturation	saturation	NOUN
admet-657	125	17	and	and	CCONJ
admet-657	125	18	inhibition	inhibition	NOUN
admet-657	125	19	have	have	AUX
admet-657	125	20	been	be	AUX
admet-657	125	21	reported	report	VERB
admet-657	125	22	[	[	X
admet-657	125	23	12	12	NUM
admet-657	125	24	]	]	PUNCT
admet-657	125	25	.	.	PUNCT
admet-657	126	1	for	for	ADP
admet-657	126	2	hydrophilic	hydrophilic	ADJ
admet-657	126	3	basic	basic	ADJ
admet-657	126	4	drugs	drug	NOUN
admet-657	126	5	,	,	PUNCT
admet-657	126	6	ion	ion	NOUN
admet-657	126	7	pair	pair	NOUN
admet-657	126	8	formation	formation	NOUN
admet-657	126	9	between	between	ADP
admet-657	126	10	a	a	DET
admet-657	126	11	drug	drug	NOUN
admet-657	126	12	cation	cation	NOUN
admet-657	126	13	and	and	CCONJ
admet-657	126	14	an	an	DET
admet-657	126	15	anionic	anionic	ADJ
admet-657	126	16	phospholipid	phospholipid	NOUN
admet-657	126	17	was	be	AUX
admet-657	126	18	suggested	suggest	VERB
admet-657	126	19	as	as	ADP
admet-657	126	20	the	the	DET
admet-657	126	21	permeation	permeation	NOUN
admet-657	126	22	mechanism	mechanism	NOUN
admet-657	126	23	[	[	X
admet-657	126	24	12	12	NUM
admet-657	126	25	,	,	PUNCT
admet-657	126	26	13	13	NUM
admet-657	126	27	]	]	PUNCT
admet-657	126	28	.	.	PUNCT
admet-657	127	1	since	since	SCONJ
admet-657	127	2	the	the	DET
admet-657	127	3	addition	addition	NOUN
admet-657	127	4	of	of	ADP
admet-657	127	5	pe	pe	PROPN
admet-657	127	6	,	,	PUNCT
admet-657	127	7	pi	pi	PROPN
admet-657	127	8	and/or	and/or	CCONJ
admet-657	127	9	pa	pa	PROPN
admet-657	127	10	significantly	significantly	ADV
admet-657	127	11	enhanced	enhance	VERB
admet-657	127	12	the	the	DET
admet-657	127	13	pe	pe	PROPN
admet-657	127	14	value	value	NOUN
admet-657	127	15	of	of	ADP
admet-657	127	16	tc	tc	NOUN
admet-657	127	17	,	,	PUNCT
admet-657	127	18	there	there	PRON
admet-657	127	19	might	might	AUX
admet-657	127	20	exist	exist	VERB
admet-657	127	21	some	some	DET
admet-657	127	22	nonspecific	nonspecific	ADJ
admet-657	127	23	inter	inter	ADJ
admet-657	127	24	-	-	ADJ
admet-657	127	25	molecular	molecular	ADJ
admet-657	127	26	interaction	interaction	NOUN
admet-657	127	27	between	between	ADP
admet-657	127	28	tc	tc	NOUN
admet-657	127	29	and	and	CCONJ
admet-657	127	30	these	these	DET
admet-657	127	31	phospholipids	phospholipid	NOUN
admet-657	127	32	other	other	ADJ
admet-657	127	33	than	than	ADP
admet-657	127	34	ion	ion	NOUN
admet-657	127	35	-	-	PUNCT
admet-657	127	36	pair	pair	NOUN
admet-657	127	37	formation	formation	NOUN
admet-657	127	38	[	[	X
admet-657	127	39	20	20	NUM
admet-657	127	40	]	]	PUNCT
admet-657	127	41	.	.	PUNCT
admet-657	128	1	only	only	ADV
admet-657	128	2	a	a	DET
admet-657	128	3	weak	weak	ADJ
admet-657	128	4	correlation	correlation	NOUN
admet-657	128	5	was	be	AUX
admet-657	128	6	observed	observe	VERB
admet-657	128	7	between	between	ADP
admet-657	128	8	log	log	PROPN
admet-657	128	9	d	d	NOUN
admet-657	128	10	and	and	CCONJ
admet-657	128	11	log	log	VERB
admet-657	128	12	pe	pe	PROPN
admet-657	128	13	,	,	PUNCT
admet-657	128	14	suggesting	suggest	VERB
admet-657	128	15	that	that	SCONJ
admet-657	128	16	the	the	DET
admet-657	128	17	inter	inter	ADJ
admet-657	128	18	-	-	ADJ
admet-657	128	19	molecular	molecular	ADJ
admet-657	128	20	interaction	interaction	NOUN
admet-657	128	21	between	between	ADP
admet-657	128	22	phospholipids	phospholipid	NOUN
admet-657	128	23	and	and	CCONJ
admet-657	128	24	tetracyclines	tetracycline	NOUN
admet-657	128	25	might	might	AUX
admet-657	128	26	be	be	AUX
admet-657	128	27	different	different	ADJ
admet-657	128	28	from	from	ADP
admet-657	128	29	that	that	PRON
admet-657	128	30	between	between	ADP
admet-657	128	31	octanol	octanol	NOUN
admet-657	128	32	and	and	CCONJ
admet-657	128	33	tetracyclines	tetracyclines	PROPN
admet-657	128	34	.	.	PROPN
admet-657	129	1	admet	admet	PROPN
admet-657	129	2	&	&	CCONJ
admet-657	129	3	dmpk	dmpk	PROPN
admet-657	129	4	7(3	7(3	NUM
admet-657	129	5	)	)	PUNCT
admet-657	129	6	(	(	PUNCT
admet-657	129	7	2019	2019	NUM
admet-657	129	8	)	)	PUNCT
admet-657	129	9	151	151	NUM
admet-657	129	10	-	-	SYM
admet-657	129	11	160	160	NUM
admet-657	129	12	permeation	permeation	NOUN
admet-657	129	13	characteristics	characteristic	NOUN
admet-657	129	14	of	of	ADP
admet-657	129	15	tetracyclines	tetracyclines	PROPN
admet-657	129	16	in	in	ADP
admet-657	129	17	pampa	pampa	PROPN
admet-657	129	18	doi	doi	PROPN
admet-657	129	19	:	:	PUNCT
admet-657	129	20	10.5599	10.5599	NUM
admet-657	129	21	/	/	SYM
admet-657	129	22	admet.657	admet.657	PROPN
admet-657	129	23	159	159	NUM
admet-657	129	24	conclusions	conclusion	NOUN
admet-657	129	25	in	in	ADP
admet-657	129	26	conclusion	conclusion	NOUN
admet-657	129	27	,	,	PUNCT
admet-657	129	28	in	in	ADP
admet-657	129	29	this	this	DET
admet-657	129	30	study	study	NOUN
admet-657	129	31	,	,	PUNCT
admet-657	129	32	the	the	DET
admet-657	129	33	permeation	permeation	NOUN
admet-657	129	34	characteristics	characteristic	NOUN
admet-657	129	35	of	of	ADP
admet-657	129	36	tc	tc	NUM
admet-657	129	37	were	be	AUX
admet-657	129	38	investigated	investigate	VERB
admet-657	129	39	in	in	ADP
admet-657	129	40	detail	detail	NOUN
admet-657	129	41	.	.	PUNCT
admet-657	130	1	the	the	DET
admet-657	130	2	phospholipid	phospholipid	NOUN
admet-657	130	3	composition	composition	NOUN
admet-657	130	4	and	and	CCONJ
admet-657	130	5	incubation	incubation	NOUN
admet-657	130	6	temperature	temperature	NOUN
admet-657	130	7	showed	show	VERB
admet-657	130	8	marked	mark	VERB
admet-657	130	9	effects	effect	NOUN
admet-657	130	10	on	on	ADP
admet-657	130	11	the	the	DET
admet-657	130	12	permeation	permeation	NOUN
admet-657	130	13	of	of	ADP
admet-657	130	14	tc	tc	NOUN
admet-657	130	15	,	,	PUNCT
admet-657	130	16	whereas	whereas	SCONJ
admet-657	130	17	the	the	DET
admet-657	130	18	ionic	ionic	ADJ
admet-657	130	19	strength	strength	NOUN
admet-657	130	20	of	of	ADP
admet-657	130	21	the	the	DET
admet-657	130	22	media	medium	NOUN
admet-657	130	23	,	,	PUNCT
admet-657	130	24	the	the	DET
admet-657	130	25	concentration	concentration	NOUN
admet-657	130	26	of	of	ADP
admet-657	130	27	tc	tc	NOUN
admet-657	130	28	,	,	PUNCT
admet-657	130	29	and	and	CCONJ
admet-657	130	30	the	the	DET
admet-657	130	31	addition	addition	NOUN
admet-657	130	32	of	of	ADP
admet-657	130	33	ion	ion	NOUN
admet-657	130	34	pair	pair	NOUN
admet-657	130	35	inhibitors	inhibitor	NOUN
admet-657	130	36	showed	show	VERB
admet-657	130	37	little	little	ADJ
admet-657	130	38	or	or	CCONJ
admet-657	130	39	no	no	PRON
admet-657	130	40	effect	effect	NOUN
admet-657	130	41	.	.	PUNCT
admet-657	131	1	conflict	conflict	NOUN
admet-657	131	2	of	of	ADP
admet-657	131	3	interest	interest	NOUN
admet-657	131	4	:	:	PUNCT
admet-657	131	5	none	none	NOUN
admet-657	131	6	.	.	PUNCT
admet-657	132	1	references	reference	NOUN
admet-657	132	2	[	[	X
admet-657	132	3	1	1	NUM
admet-657	132	4	]	]	PUNCT
admet-657	132	5	a.	a.	NOUN
admet-657	132	6	pagliara	pagliara	PROPN
admet-657	132	7	,	,	PUNCT
admet-657	132	8	p.	p.	PROPN
admet-657	132	9	carrupt	carrupt	PROPN
admet-657	132	10	,	,	PUNCT
admet-657	132	11	g.	g.	PROPN
admet-657	132	12	caron	caron	PROPN
admet-657	132	13	,	,	PUNCT
admet-657	132	14	p.	p.	PROPN
admet-657	132	15	gaillard	gaillard	PROPN
admet-657	132	16	,	,	PUNCT
admet-657	132	17	b.	b.	PROPN
admet-657	132	18	testa	testa	PROPN
admet-657	132	19	.	.	PUNCT
admet-657	133	1	lipophilicity	lipophilicity	NOUN
admet-657	133	2	profiles	profile	NOUN
admet-657	133	3	of	of	ADP
admet-657	133	4	ampholytes	ampholyte	NOUN
admet-657	133	5	.	.	PUNCT
admet-657	134	1	chem	chem	PROPN
admet-657	134	2	.	.	PUNCT
admet-657	135	1	rev	rev	PROPN
admet-657	135	2	.	.	PROPN
admet-657	135	3	97	97	NUM
admet-657	135	4	(	(	PUNCT
admet-657	135	5	1997	1997	NUM
admet-657	135	6	)	)	PUNCT
admet-657	135	7	3385	3385	NUM
admet-657	135	8	-	-	SYM
admet-657	135	9	3400	3400	NUM
admet-657	135	10	.	.	PUNCT
admet-657	136	1	[	[	X
admet-657	136	2	2	2	NUM
admet-657	136	3	]	]	PUNCT
admet-657	136	4	c.	c.	PROPN
admet-657	136	5	chen	chen	PROPN
admet-657	136	6	.	.	PUNCT
admet-657	137	1	some	some	DET
admet-657	137	2	pharmacokinetic	pharmacokinetic	ADJ
admet-657	137	3	aspects	aspect	NOUN
admet-657	137	4	of	of	ADP
admet-657	137	5	the	the	DET
admet-657	137	6	lipophilic	lipophilic	ADJ
admet-657	137	7	terfenadine	terfenadine	NOUN
admet-657	137	8	and	and	CCONJ
admet-657	137	9	zwitterionic	zwitterionic	ADJ
admet-657	137	10	fexofenadine	fexofenadine	NOUN
admet-657	137	11	in	in	ADP
admet-657	137	12	humans	human	NOUN
admet-657	137	13	.	.	PUNCT
admet-657	138	1	drugs	drug	NOUN
admet-657	138	2	in	in	ADP
admet-657	138	3	r	r	PROPN
admet-657	138	4	&	&	CCONJ
admet-657	138	5	d.	d.	PROPN
admet-657	138	6	8	8	NUM
admet-657	138	7	(	(	PUNCT
admet-657	138	8	2007	2007	NUM
admet-657	138	9	)	)	PUNCT
admet-657	138	10	301	301	NUM
admet-657	138	11	-	-	SYM
admet-657	138	12	314	314	NUM
admet-657	138	13	.	.	PUNCT
admet-657	139	1	[	[	X
admet-657	139	2	3	3	X
admet-657	139	3	]	]	X
admet-657	139	4	c.	c.	PROPN
admet-657	139	5	jamieson	jamieson	PROPN
admet-657	139	6	,	,	PUNCT
admet-657	139	7	e.m	e.m	PROPN
admet-657	139	8	.	.	PROPN
admet-657	139	9	moir	moir	PROPN
admet-657	139	10	,	,	PUNCT
admet-657	139	11	z.	z.	PROPN
admet-657	139	12	rankovic	rankovic	PROPN
admet-657	139	13	,	,	PUNCT
admet-657	139	14	g.	g.	PROPN
admet-657	139	15	wishart	wishart	PROPN
admet-657	139	16	.	.	PUNCT
admet-657	140	1	medicinal	medicinal	ADJ
admet-657	140	2	chemistry	chemistry	NOUN
admet-657	140	3	of	of	ADP
admet-657	140	4	herg	herg	PROPN
admet-657	140	5	optimizations	optimization	NOUN
admet-657	140	6	:	:	PUNCT
admet-657	140	7	highlights	highlight	NOUN
admet-657	140	8	and	and	CCONJ
admet-657	140	9	hang	hang	NOUN
admet-657	140	10	-	-	PUNCT
admet-657	140	11	ups	up	NOUN
admet-657	140	12	.	.	PUNCT
admet-657	141	1	j.	j.	PROPN
admet-657	141	2	med	med	PROPN
admet-657	141	3	.	.	PROPN
admet-657	141	4	chem	chem	PROPN
admet-657	141	5	.	.	PUNCT
admet-657	142	1	49	49	NUM
admet-657	142	2	(	(	PUNCT
admet-657	142	3	2006	2006	NUM
admet-657	142	4	)	)	PUNCT
admet-657	142	5	5029	5029	NUM
admet-657	142	6	-	-	SYM
admet-657	142	7	5046	5046	NUM
admet-657	142	8	.	.	PUNCT
admet-657	143	1	[	[	X
admet-657	143	2	4	4	X
admet-657	143	3	]	]	PUNCT
admet-657	143	4	k.	k.	PROPN
admet-657	143	5	tomizawa	tomizawa	PROPN
admet-657	143	6	,	,	PUNCT
admet-657	143	7	k.	k.	PROPN
admet-657	143	8	sugano	sugano	PROPN
admet-657	143	9	,	,	PUNCT
admet-657	143	10	h.	h.	PROPN
admet-657	143	11	yamada	yamada	PROPN
admet-657	143	12	.	.	PUNCT
admet-657	144	1	physicochemical	physicochemical	ADJ
admet-657	144	2	and	and	CCONJ
admet-657	144	3	cell	cell	NOUN
admet-657	144	4	-	-	PUNCT
admet-657	144	5	based	base	VERB
admet-657	144	6	approach	approach	NOUN
admet-657	144	7	for	for	ADP
admet-657	144	8	early	early	ADJ
admet-657	144	9	screening	screening	NOUN
admet-657	144	10	of	of	ADP
admet-657	144	11	phospholipidosis	phospholipidosis	NOUN
admet-657	144	12	-	-	PUNCT
admet-657	144	13	inducing	induce	VERB
admet-657	144	14	potential	potential	NOUN
admet-657	144	15	.	.	PUNCT
admet-657	145	1	j.	j.	PROPN
admet-657	145	2	toxicol	toxicol	PROPN
admet-657	145	3	.	.	PUNCT
admet-657	146	1	sci	sci	PROPN
admet-657	146	2	.	.	PROPN
admet-657	147	1	31	31	NUM
admet-657	148	1	(	(	PUNCT
admet-657	148	2	2006	2006	NUM
admet-657	148	3	)	)	PUNCT
admet-657	148	4	315	315	NUM
admet-657	148	5	-	-	SYM
admet-657	148	6	324	324	NUM
admet-657	148	7	.	.	PUNCT
admet-657	149	1	[	[	X
admet-657	149	2	5	5	NUM
admet-657	149	3	]	]	X
admet-657	149	4	k.f	k.f	PROPN
admet-657	149	5	.	.	PROPN
admet-657	149	6	hermann	hermann	PROPN
admet-657	149	7	,	,	PUNCT
admet-657	149	8	c.s	c.s	PROPN
admet-657	149	9	.	.	PROPN
admet-657	149	10	neuhaus	neuhaus	PROPN
admet-657	149	11	,	,	PUNCT
admet-657	149	12	v.	v.	PROPN
admet-657	149	13	micallef	micallef	PROPN
admet-657	149	14	,	,	PUNCT
admet-657	149	15	b.	b.	PROPN
admet-657	149	16	wagner	wagner	PROPN
admet-657	149	17	,	,	PUNCT
admet-657	149	18	m.	m.	PROPN
admet-657	149	19	hatibović	hatibović	PROPN
admet-657	149	20	,	,	PUNCT
admet-657	149	21	h.e	h.e	PROPN
admet-657	149	22	.	.	PROPN
admet-657	149	23	aschmann	aschmann	PROPN
admet-657	149	24	,	,	PUNCT
admet-657	149	25	f.	f.	PROPN
admet-657	149	26	paech	paech	PROPN
admet-657	149	27	,	,	PUNCT
admet-657	149	28	r.	r.	PROPN
admet-657	149	29	alvarez	alvarez	PROPN
admet-657	149	30	-	-	PUNCT
admet-657	149	31	sanchez	sanchez	PROPN
admet-657	149	32	,	,	PUNCT
admet-657	149	33	s.d	s.d	PROPN
admet-657	149	34	.	.	PROPN
admet-657	149	35	krämer	krämer	PROPN
admet-657	149	36	,	,	PUNCT
admet-657	149	37	s.	s.	PROPN
admet-657	149	38	belli	belli	PROPN
admet-657	149	39	.	.	PUNCT
admet-657	150	1	kinetics	kinetic	NOUN
admet-657	150	2	of	of	ADP
admet-657	150	3	lipid	lipid	ADJ
admet-657	150	4	bilayer	bilayer	NOUN
admet-657	150	5	permeation	permeation	NOUN
admet-657	150	6	of	of	ADP
admet-657	150	7	a	a	DET
admet-657	150	8	series	series	NOUN
admet-657	150	9	of	of	ADP
admet-657	150	10	ionisable	ionisable	ADJ
admet-657	150	11	drugs	drug	NOUN
admet-657	150	12	and	and	CCONJ
admet-657	150	13	their	their	PRON
admet-657	150	14	correlation	correlation	NOUN
admet-657	150	15	with	with	ADP
admet-657	150	16	human	human	ADJ
admet-657	150	17	transporter	transporter	NOUN
admet-657	150	18	-	-	PUNCT
admet-657	150	19	independent	independent	ADJ
admet-657	150	20	intestinal	intestinal	ADJ
admet-657	150	21	permeability	permeability	NOUN
admet-657	150	22	.	.	PUNCT
admet-657	151	1	eur	eur	PROPN
admet-657	151	2	.	.	PUNCT
admet-657	152	1	j.	j.	PROPN
admet-657	152	2	pharm	pharm	PROPN
admet-657	152	3	.	.	PUNCT
admet-657	153	1	sci	sci	PROPN
admet-657	153	2	.	.	PROPN
admet-657	154	1	104	104	NUM
admet-657	154	2	(	(	PUNCT
admet-657	154	3	2017	2017	NUM
admet-657	154	4	)	)	PUNCT
admet-657	154	5	150	150	NUM
admet-657	154	6	-	-	SYM
admet-657	154	7	161	161	NUM
admet-657	154	8	.	.	PUNCT
admet-657	155	1	[	[	X
admet-657	155	2	6	6	NUM
admet-657	155	3	]	]	X
admet-657	155	4	k.y	k.y	PROPN
admet-657	155	5	.	.	PROPN
admet-657	155	6	tam	tam	PROPN
admet-657	155	7	,	,	PUNCT
admet-657	155	8	a.	a.	NOUN
admet-657	155	9	avdeef	avdeef	PROPN
admet-657	155	10	,	,	PUNCT
admet-657	155	11	o.	o.	PROPN
admet-657	155	12	tsinman	tsinman	NOUN
admet-657	155	13	,	,	PUNCT
admet-657	155	14	n.	n.	PROPN
admet-657	155	15	sun	sun	PROPN
admet-657	155	16	.	.	PUNCT
admet-657	156	1	the	the	DET
admet-657	156	2	permeation	permeation	NOUN
admet-657	156	3	of	of	ADP
admet-657	156	4	amphoteric	amphoteric	ADJ
admet-657	156	5	drugs	drug	NOUN
admet-657	156	6	through	through	ADP
admet-657	156	7	artificial	artificial	ADJ
admet-657	156	8	membranes−	membranes−	NOUN
admet-657	156	9	an	an	PRON
admet-657	156	10	in	in	ADP
admet-657	156	11	combo	combo	NOUN
admet-657	156	12	absorption	absorption	NOUN
admet-657	156	13	model	model	NOUN
admet-657	156	14	based	base	VERB
admet-657	156	15	on	on	ADP
admet-657	156	16	paracellular	paracellular	ADJ
admet-657	156	17	and	and	CCONJ
admet-657	156	18	transmembrane	transmembrane	ADJ
admet-657	156	19	permeability	permeability	NOUN
admet-657	156	20	.	.	PUNCT
admet-657	157	1	j.	j.	PROPN
admet-657	157	2	med	med	PROPN
admet-657	157	3	.	.	PROPN
admet-657	157	4	chem	chem	PROPN
admet-657	157	5	.	.	PUNCT
admet-657	158	1	53	53	NUM
admet-657	158	2	(	(	PUNCT
admet-657	158	3	2009	2009	NUM
admet-657	158	4	)	)	PUNCT
admet-657	158	5	392	392	NUM
admet-657	158	6	-	-	SYM
admet-657	158	7	401	401	NUM
admet-657	158	8	.	.	PUNCT
admet-657	159	1	[	[	X
admet-657	159	2	7	7	X
admet-657	159	3	]	]	X
admet-657	159	4	m.	m.	NOUN
admet-657	159	5	kansy	kansy	PROPN
admet-657	159	6	,	,	PUNCT
admet-657	159	7	f.	f.	PROPN
admet-657	159	8	senner	senner	PROPN
admet-657	159	9	,	,	PUNCT
admet-657	159	10	k.	k.	PROPN
admet-657	159	11	gubernator	gubernator	PROPN
admet-657	159	12	.	.	PUNCT
admet-657	160	1	physicochemical	physicochemical	ADJ
admet-657	160	2	high	high	ADJ
admet-657	160	3	throughput	throughput	NOUN
admet-657	160	4	screening	screening	NOUN
admet-657	160	5	:	:	PUNCT
admet-657	160	6	parallel	parallel	ADJ
admet-657	160	7	artificial	artificial	ADJ
admet-657	160	8	membrane	membrane	NOUN
admet-657	160	9	permeation	permeation	NOUN
admet-657	160	10	assay	assay	VERB
admet-657	160	11	in	in	ADP
admet-657	160	12	the	the	DET
admet-657	160	13	description	description	NOUN
admet-657	160	14	of	of	ADP
admet-657	160	15	passive	passive	ADJ
admet-657	160	16	absorption	absorption	NOUN
admet-657	160	17	processes	process	NOUN
admet-657	160	18	.	.	PUNCT
admet-657	161	1	j.	j.	PROPN
admet-657	161	2	med	med	PROPN
admet-657	161	3	.	.	PROPN
admet-657	161	4	chem	chem	PROPN
admet-657	161	5	.	.	PUNCT
admet-657	162	1	41	41	NUM
admet-657	162	2	(	(	PUNCT
admet-657	162	3	1998	1998	NUM
admet-657	162	4	)	)	PUNCT
admet-657	162	5	1007	1007	NUM
admet-657	162	6	-	-	SYM
admet-657	162	7	1010	1010	NUM
admet-657	162	8	.	.	PUNCT
admet-657	163	1	[	[	X
admet-657	163	2	8	8	NUM
admet-657	163	3	]	]	X
admet-657	163	4	f.	f.	PROPN
admet-657	163	5	wohnsland	wohnsland	PROPN
admet-657	163	6	,	,	PUNCT
admet-657	163	7	b.	b.	PROPN
admet-657	163	8	faller	faller	PROPN
admet-657	163	9	.	.	PUNCT
admet-657	164	1	high	high	ADJ
admet-657	164	2	-	-	PUNCT
admet-657	164	3	throughput	throughput	NOUN
admet-657	164	4	permeability	permeability	NOUN
admet-657	164	5	ph	ph	NOUN
admet-657	164	6	profile	profile	NOUN
admet-657	164	7	and	and	CCONJ
admet-657	164	8	high	high	ADJ
admet-657	164	9	-	-	PUNCT
admet-657	164	10	throughput	throughput	NOUN
admet-657	164	11	alkane	alkane	NOUN
admet-657	164	12	/	/	SYM
admet-657	164	13	water	water	NOUN
admet-657	164	14	log	log	NOUN
admet-657	164	15	p	p	NOUN
admet-657	164	16	with	with	ADP
admet-657	164	17	artificial	artificial	ADJ
admet-657	164	18	membranes	membrane	NOUN
admet-657	164	19	.	.	PUNCT
admet-657	165	1	j.	j.	PROPN
admet-657	165	2	med	med	PROPN
admet-657	165	3	.	.	PROPN
admet-657	165	4	chem	chem	PROPN
admet-657	165	5	.	.	PUNCT
admet-657	166	1	44	44	NUM
admet-657	166	2	(	(	PUNCT
admet-657	166	3	2001	2001	NUM
admet-657	166	4	)	)	PUNCT
admet-657	166	5	923	923	NUM
admet-657	166	6	-	-	SYM
admet-657	166	7	930	930	NUM
admet-657	166	8	.	.	PUNCT
admet-657	167	1	[	[	X
admet-657	167	2	9	9	NUM
admet-657	167	3	]	]	PUNCT
admet-657	167	4	k.	k.	PROPN
admet-657	167	5	sugano	sugano	PROPN
admet-657	167	6	,	,	PUNCT
admet-657	167	7	h.	h.	PROPN
admet-657	167	8	hamada	hamada	PROPN
admet-657	167	9	,	,	PUNCT
admet-657	167	10	m.	m.	PROPN
admet-657	167	11	machida	machida	PROPN
admet-657	167	12	,	,	PUNCT
admet-657	167	13	h.	h.	PROPN
admet-657	167	14	ushio	ushio	PROPN
admet-657	167	15	.	.	PUNCT
admet-657	168	1	high	high	ADJ
admet-657	168	2	throughput	throughput	NOUN
admet-657	168	3	prediction	prediction	NOUN
admet-657	168	4	of	of	ADP
admet-657	168	5	oral	oral	ADJ
admet-657	168	6	absorption	absorption	NOUN
admet-657	168	7	:	:	PUNCT
admet-657	168	8	improvement	improvement	NOUN
admet-657	168	9	of	of	ADP
admet-657	168	10	the	the	DET
admet-657	168	11	composition	composition	NOUN
admet-657	168	12	of	of	ADP
admet-657	168	13	the	the	DET
admet-657	168	14	lipid	lipid	NOUN
admet-657	168	15	solution	solution	NOUN
admet-657	168	16	used	use	VERB
admet-657	168	17	in	in	ADP
admet-657	168	18	parallel	parallel	ADJ
admet-657	168	19	artificial	artificial	ADJ
admet-657	168	20	membrane	membrane	NOUN
admet-657	168	21	permeation	permeation	NOUN
admet-657	168	22	assay	assay	NOUN
admet-657	168	23	.	.	PUNCT
admet-657	169	1	j.	j.	PROPN
admet-657	169	2	biomol	biomol	PROPN
admet-657	169	3	.	.	PUNCT
admet-657	170	1	screen	screen	NOUN
admet-657	170	2	.	.	PUNCT
admet-657	171	1	6	6	NUM
admet-657	171	2	(	(	PUNCT
admet-657	171	3	2001	2001	NUM
admet-657	171	4	)	)	PUNCT
admet-657	171	5	189	189	NUM
admet-657	171	6	-	-	SYM
admet-657	171	7	196	196	NUM
admet-657	171	8	.	.	PUNCT
admet-657	172	1	[	[	X
admet-657	172	2	10	10	NUM
admet-657	172	3	]	]	X
admet-657	172	4	l.	l.	PROPN
admet-657	172	5	di	di	PROPN
admet-657	172	6	,	,	PUNCT
admet-657	172	7	e.h	e.h	PROPN
admet-657	172	8	.	.	PROPN
admet-657	172	9	kerns	kerns	PROPN
admet-657	172	10	,	,	PUNCT
admet-657	172	11	k.	k.	PROPN
admet-657	172	12	fan	fan	PROPN
admet-657	172	13	,	,	PUNCT
admet-657	172	14	o.j	o.j	PROPN
admet-657	172	15	.	.	PROPN
admet-657	172	16	mcconnell	mcconnell	PROPN
admet-657	172	17	,	,	PUNCT
admet-657	172	18	g.t	g.t	PROPN
admet-657	172	19	.	.	PROPN
admet-657	172	20	carter	carter	PROPN
admet-657	172	21	.	.	PUNCT
admet-657	173	1	high	high	ADJ
admet-657	173	2	throughput	throughput	PROPN
admet-657	173	3	artificial	artificial	ADJ
admet-657	173	4	membrane	membrane	NOUN
admet-657	173	5	permeability	permeability	NOUN
admet-657	173	6	assay	assay	VERB
admet-657	173	7	for	for	ADP
admet-657	173	8	blood	blood	NOUN
admet-657	173	9	–	–	PUNCT
admet-657	173	10	brain	brain	NOUN
admet-657	173	11	barrier	barrier	NOUN
admet-657	173	12	.	.	PUNCT
admet-657	174	1	eur	eur	PROPN
admet-657	174	2	.	.	PUNCT
admet-657	175	1	j.	j.	PROPN
admet-657	175	2	med	med	PROPN
admet-657	175	3	.	.	PROPN
admet-657	175	4	chem	chem	PROPN
admet-657	175	5	.	.	PUNCT
admet-657	176	1	38	38	NUM
admet-657	176	2	(	(	PUNCT
admet-657	176	3	2003	2003	NUM
admet-657	176	4	)	)	PUNCT
admet-657	176	5	223	223	NUM
admet-657	176	6	-	-	SYM
admet-657	176	7	232	232	NUM
admet-657	176	8	.	.	PUNCT
admet-657	177	1	[	[	X
admet-657	177	2	11	11	NUM
admet-657	177	3	]	]	PUNCT
admet-657	177	4	m.	m.	NOUN
admet-657	177	5	bermejo	bermejo	PROPN
admet-657	177	6	,	,	PUNCT
admet-657	177	7	a.	a.	NOUN
admet-657	177	8	avdeef	avdeef	PROPN
admet-657	177	9	,	,	PUNCT
admet-657	177	10	a.	a.	NOUN
admet-657	177	11	ruiz	ruiz	PROPN
admet-657	177	12	,	,	PUNCT
admet-657	177	13	r.	r.	PROPN
admet-657	177	14	nalda	nalda	PROPN
admet-657	177	15	,	,	PUNCT
admet-657	177	16	j.a	j.a	PROPN
admet-657	177	17	.	.	PROPN
admet-657	177	18	ruell	ruell	PROPN
admet-657	177	19	,	,	PUNCT
admet-657	177	20	o.	o.	PROPN
admet-657	177	21	tsinman	tsinman	PROPN
admet-657	177	22	,	,	PUNCT
admet-657	177	23	i.	i.	PROPN
admet-657	177	24	gonzález	gonzález	PROPN
admet-657	177	25	,	,	PUNCT
admet-657	177	26	c.	c.	PROPN
admet-657	177	27	fernández	fernández	PROPN
admet-657	177	28	,	,	PUNCT
admet-657	177	29	g.	g.	PROPN
admet-657	177	30	sánchez	sánchez	PROPN
admet-657	177	31	,	,	PUNCT
admet-657	177	32	t.m	t.m	PROPN
admet-657	177	33	.	.	PROPN
admet-657	177	34	garrigues	garrigues	PROPN
admet-657	177	35	.	.	PUNCT
admet-657	178	1	pampa	pampa	PROPN
admet-657	178	2	—	—	PUNCT
admet-657	178	3	a	a	DET
admet-657	178	4	drug	drug	NOUN
admet-657	178	5	absorption	absorption	NOUN
admet-657	178	6	in	in	ADP
admet-657	178	7	vitro	vitro	X
admet-657	178	8	model	model	NOUN
admet-657	178	9	:	:	PUNCT
admet-657	178	10	7	7	X
admet-657	178	11	.	.	NOUN
admet-657	178	12	comparing	compare	VERB
admet-657	178	13	rat	rat	NOUN
admet-657	178	14	in	in	ADP
admet-657	178	15	situ	situ	NOUN
admet-657	178	16	,	,	PUNCT
admet-657	178	17	caco-2	caco-2	NOUN
admet-657	178	18	,	,	PUNCT
admet-657	178	19	and	and	CCONJ
admet-657	178	20	pampa	pampa	NOUN
admet-657	178	21	permeability	permeability	NOUN
admet-657	178	22	of	of	ADP
admet-657	178	23	fluoroquinolones	fluoroquinolone	NOUN
admet-657	178	24	.	.	PUNCT
admet-657	179	1	eur	eur	PROPN
admet-657	179	2	.	.	PUNCT
admet-657	180	1	j.	j.	PROPN
admet-657	180	2	pharm	pharm	PROPN
admet-657	180	3	.	.	PUNCT
admet-657	181	1	sci	sci	PROPN
admet-657	181	2	.	.	PROPN
admet-657	181	3	21	21	NUM
admet-657	181	4	(	(	PUNCT
admet-657	181	5	2004	2004	NUM
admet-657	181	6	)	)	PUNCT
admet-657	181	7	429	429	NUM
admet-657	181	8	-	-	SYM
admet-657	181	9	441	441	NUM
admet-657	181	10	.	.	PUNCT
admet-657	182	1	[	[	X
admet-657	182	2	12	12	NUM
admet-657	182	3	]	]	PUNCT
admet-657	182	4	k.	k.	PROPN
admet-657	182	5	sugano	sugano	PROPN
admet-657	182	6	,	,	PUNCT
admet-657	182	7	y.	y.	PROPN
admet-657	182	8	nabuchi	nabuchi	PROPN
admet-657	182	9	,	,	PUNCT
admet-657	182	10	m.	m.	PROPN
admet-657	182	11	machida	machida	PROPN
admet-657	182	12	,	,	PUNCT
admet-657	182	13	y.	y.	PROPN
admet-657	182	14	asoh	asoh	PROPN
admet-657	182	15	.	.	PUNCT
admet-657	183	1	permeation	permeation	NOUN
admet-657	183	2	characteristics	characteristic	NOUN
admet-657	183	3	of	of	ADP
admet-657	183	4	a	a	DET
admet-657	183	5	hydrophilic	hydrophilic	ADJ
admet-657	183	6	basic	basic	ADJ
admet-657	183	7	compound	compound	NOUN
admet-657	183	8	across	across	ADP
admet-657	183	9	a	a	DET
admet-657	183	10	bio	bio	ADJ
admet-657	183	11	-	-	ADJ
admet-657	183	12	mimetic	mimetic	ADJ
admet-657	183	13	artificial	artificial	ADJ
admet-657	183	14	membrane	membrane	NOUN
admet-657	183	15	.	.	PUNCT
admet-657	184	1	int	int	NOUN
admet-657	184	2	.	.	PUNCT
admet-657	185	1	j.	j.	PROPN
admet-657	185	2	pharm	pharm	PROPN
admet-657	185	3	.	.	PUNCT
admet-657	186	1	275	275	NUM
admet-657	186	2	(	(	PUNCT
admet-657	186	3	2004	2004	NUM
admet-657	186	4	)	)	PUNCT
admet-657	186	5	271	271	NUM
admet-657	186	6	-	-	SYM
admet-657	186	7	278	278	NUM
admet-657	186	8	.	.	PUNCT
admet-657	187	1	[	[	X
admet-657	187	2	13	13	NUM
admet-657	187	3	]	]	X
admet-657	187	4	z.s	z.s	PROPN
admet-657	187	5	.	.	PROPN
admet-657	187	6	teksin	teksin	PROPN
admet-657	187	7	,	,	PUNCT
admet-657	187	8	k.	k.	PROPN
admet-657	187	9	hom	hom	PROPN
admet-657	187	10	,	,	PUNCT
admet-657	187	11	a.	a.	PROPN
admet-657	187	12	balakrishnan	balakrishnan	PROPN
admet-657	187	13	,	,	PUNCT
admet-657	187	14	j.e	j.e	PROPN
admet-657	187	15	.	.	PROPN
admet-657	187	16	polli	polli	PROPN
admet-657	187	17	.	.	PUNCT
admet-657	188	1	ion	ion	NOUN
admet-657	188	2	pair	pair	NOUN
admet-657	188	3	-	-	PUNCT
admet-657	188	4	mediated	mediate	VERB
admet-657	188	5	transport	transport	NOUN
admet-657	188	6	of	of	ADP
admet-657	188	7	metoprolol	metoprolol	PROPN
admet-657	188	8	across	across	ADP
admet-657	188	9	a	a	DET
admet-657	188	10	three	three	NUM
admet-657	188	11	lipid	lipid	NOUN
admet-657	188	12	-	-	PUNCT
admet-657	188	13	component	component	NOUN
admet-657	188	14	pampa	pampa	NOUN
admet-657	188	15	system	system	NOUN
admet-657	188	16	.	.	PUNCT
admet-657	189	1	j.	j.	PROPN
admet-657	189	2	controlled	control	VERB
admet-657	189	3	release	release	NOUN
admet-657	189	4	.	.	PUNCT
admet-657	190	1	116	116	NUM
admet-657	190	2	(	(	PUNCT
admet-657	190	3	2006	2006	NUM
admet-657	190	4	)	)	PUNCT
admet-657	190	5	50	50	NUM
admet-657	190	6	-	-	SYM
admet-657	190	7	57	57	NUM
admet-657	190	8	.	.	PUNCT
admet-657	191	1	[	[	X
admet-657	191	2	14	14	NUM
admet-657	191	3	]	]	X
admet-657	191	4	s.	s.	PROPN
admet-657	191	5	babić	babić	PROPN
admet-657	191	6	,	,	PUNCT
admet-657	191	7	a.j	a.j	PROPN
admet-657	191	8	.	.	PROPN
admet-657	191	9	horvat	horvat	PROPN
admet-657	191	10	,	,	PUNCT
admet-657	191	11	d.m	d.m	PROPN
admet-657	191	12	.	.	PROPN
admet-657	191	13	pavlović	pavlović	NOUN
admet-657	191	14	,	,	PUNCT
admet-657	191	15	m.	m.	NOUN
admet-657	191	16	kaštelan	kaštelan	PROPN
admet-657	191	17	-	-	PUNCT
admet-657	191	18	macan	macan	PROPN
admet-657	191	19	.	.	PUNCT
admet-657	192	1	determination	determination	NOUN
admet-657	192	2	of	of	ADP
admet-657	192	3	pka	pka	PROPN
admet-657	192	4	values	value	NOUN
admet-657	192	5	of	of	ADP
admet-657	192	6	active	active	ADJ
admet-657	192	7	pharmaceutical	pharmaceutical	ADJ
admet-657	192	8	ingredients	ingredient	NOUN
admet-657	192	9	.	.	PUNCT
admet-657	193	1	trac	trac	NOUN
admet-657	193	2	-	-	PUNCT
admet-657	193	3	trend	trend	NOUN
admet-657	193	4	anal	anal	NOUN
admet-657	193	5	.	.	PUNCT
admet-657	194	1	chem	chem	PROPN
admet-657	194	2	.	.	PUNCT
admet-657	195	1	26	26	NUM
admet-657	195	2	(	(	PUNCT
admet-657	195	3	2007	2007	NUM
admet-657	195	4	)	)	PUNCT
admet-657	195	5	1043	1043	NUM
admet-657	195	6	-	-	SYM
admet-657	195	7	1061	1061	NUM
admet-657	195	8	.	.	PUNCT
admet-657	196	1	[	[	X
admet-657	196	2	15	15	NUM
admet-657	196	3	]	]	X
admet-657	196	4	minocycline	minocycline	ADJ
admet-657	196	5	drug	drug	NOUN
admet-657	196	6	information	information	NOUN
admet-657	196	7	,	,	PUNCT
admet-657	196	8	www.info.pmda.go.jp/go/interview/2/671450_6152005m1043_2_1f	www.info.pmda.go.jp/go/interview/2/671450_6152005m1043_2_1f	PROPN
admet-657	196	9	.	.	PROPN
admet-657	196	10	2019	2019	NUM
admet-657	196	11	.	.	PUNCT
admet-657	197	1	http://www.info.pmda.go.jp/go/interview/2/671450_6152005m1043_2_1f	http://www.info.pmda.go.jp/go/interview/2/671450_6152005m1043_2_1f	PROPN
admet-657	197	2	yamauchi	yamauchi	PROPN
admet-657	197	3	and	and	CCONJ
admet-657	197	4	sugano	sugano	VERB
admet-657	197	5	admet	admet	PROPN
admet-657	197	6	&	&	CCONJ
admet-657	197	7	dmpk	dmpk	PROPN
admet-657	197	8	7(3	7(3	NUM
admet-657	197	9	)	)	PUNCT
admet-657	197	10	(	(	PUNCT
admet-657	197	11	2019	2019	NUM
admet-657	197	12	)	)	PUNCT
admet-657	197	13	151	151	NUM
admet-657	197	14	-	-	SYM
admet-657	197	15	160	160	NUM
admet-657	197	16	160	160	NUM
admet-657	197	17	[	[	X
admet-657	197	18	16	16	NUM
admet-657	197	19	]	]	PUNCT
admet-657	197	20	s.	s.	PROPN
admet-657	197	21	şanli	şanli	PROPN
admet-657	197	22	,	,	PUNCT
admet-657	197	23	n.	n.	NOUN
admet-657	197	24	şanli	şanli	PROPN
admet-657	197	25	,	,	PUNCT
admet-657	197	26	g.	g.	PROPN
admet-657	197	27	alsancak	alsancak	PROPN
admet-657	197	28	.	.	PUNCT
admet-657	198	1	determination	determination	NOUN
admet-657	198	2	of	of	ADP
admet-657	198	3	protonation	protonation	NOUN
admet-657	198	4	constants	constant	NOUN
admet-657	198	5	of	of	ADP
admet-657	198	6	some	some	DET
admet-657	198	7	tetracycline	tetracycline	ADJ
admet-657	198	8	antibiotics	antibiotic	NOUN
admet-657	198	9	by	by	ADP
admet-657	198	10	potentiometry	potentiometry	NOUN
admet-657	198	11	and	and	CCONJ
admet-657	198	12	lc	lc	NOUN
admet-657	198	13	methods	method	NOUN
admet-657	198	14	in	in	ADP
admet-657	198	15	water	water	NOUN
admet-657	198	16	and	and	CCONJ
admet-657	198	17	acetonitrile	acetonitrile	ADJ
admet-657	198	18	-	-	PUNCT
admet-657	198	19	water	water	NOUN
admet-657	198	20	binary	binary	ADJ
admet-657	198	21	mixtures	mixture	NOUN
admet-657	198	22	.	.	PUNCT
admet-657	199	1	j.	j.	PROPN
admet-657	199	2	braz	braz	PROPN
admet-657	199	3	.	.	PUNCT
admet-657	199	4	chem	chem	PROPN
admet-657	199	5	.	.	PUNCT
admet-657	200	1	soc	soc	PROPN
admet-657	200	2	.	.	PUNCT
admet-657	201	1	20	20	NUM
admet-657	201	2	(	(	PUNCT
admet-657	201	3	2009	2009	NUM
admet-657	201	4	)	)	PUNCT
admet-657	201	5	939	939	NUM
admet-657	201	6	-	-	SYM
admet-657	201	7	946	946	NUM
admet-657	201	8	.	.	PUNCT
admet-657	202	1	[	[	X
admet-657	202	2	17	17	NUM
admet-657	202	3	]	]	X
admet-657	202	4	j.l	j.l	PROPN
admet-657	202	5	.	.	PROPN
admet-657	202	6	colaizzi	colaizzi	PROPN
admet-657	202	7	,	,	PUNCT
admet-657	202	8	p.r	p.r	PROPN
admet-657	202	9	.	.	PROPN
admet-657	202	10	klink	klink	PROPN
admet-657	202	11	.	.	PUNCT
admet-657	203	1	ph‐partition	ph‐partition	NOUN
admet-657	203	2	behavior	behavior	NOUN
admet-657	203	3	of	of	ADP
admet-657	203	4	tetracyclines	tetracyclines	PROPN
admet-657	203	5	.	.	PUNCT
admet-657	204	1	j.	j.	PROPN
admet-657	204	2	pharm	pharm	PROPN
admet-657	204	3	.	.	PUNCT
admet-657	205	1	sci	sci	PROPN
admet-657	205	2	.	.	PROPN
admet-657	206	1	58	58	NUM
admet-657	206	2	(	(	PUNCT
admet-657	206	3	1969	1969	NUM
admet-657	206	4	)	)	PUNCT
admet-657	206	5	1184	1184	NUM
admet-657	206	6	-	-	SYM
admet-657	206	7	1189	1189	NUM
admet-657	206	8	.	.	PUNCT
admet-657	207	1	[	[	X
admet-657	207	2	18	18	NUM
admet-657	207	3	]	]	X
admet-657	207	4	c.a	c.a	PROPN
admet-657	207	5	.	.	PROPN
admet-657	207	6	lipinski	lipinski	PROPN
admet-657	207	7	,	,	PUNCT
admet-657	207	8	f.	f.	PROPN
admet-657	207	9	lombardo	lombardo	PROPN
admet-657	207	10	,	,	PUNCT
admet-657	207	11	b.w	b.w	PROPN
admet-657	207	12	.	.	PROPN
admet-657	207	13	dominy	dominy	PROPN
admet-657	207	14	,	,	PUNCT
admet-657	207	15	p.j	p.j	PROPN
admet-657	207	16	.	.	PROPN
admet-657	207	17	feeney	feeney	PROPN
admet-657	207	18	.	.	PUNCT
admet-657	208	1	experimental	experimental	ADJ
admet-657	208	2	and	and	CCONJ
admet-657	208	3	computational	computational	ADJ
admet-657	208	4	approaches	approach	NOUN
admet-657	208	5	to	to	PART
admet-657	208	6	estimate	estimate	VERB
admet-657	208	7	solubility	solubility	NOUN
admet-657	208	8	and	and	CCONJ
admet-657	208	9	permeability	permeability	NOUN
admet-657	208	10	in	in	ADP
admet-657	208	11	drug	drug	NOUN
admet-657	208	12	discovery	discovery	NOUN
admet-657	208	13	and	and	CCONJ
admet-657	208	14	development	development	NOUN
admet-657	208	15	settings	setting	NOUN
admet-657	208	16	.	.	PUNCT
admet-657	209	1	adv	adv	PROPN
admet-657	209	2	.	.	PUNCT
admet-657	209	3	drug	drug	PROPN
admet-657	209	4	deliv	deliv	PROPN
admet-657	209	5	.	.	PUNCT
admet-657	210	1	rev	rev	PROPN
admet-657	210	2	.	.	PROPN
admet-657	210	3	23	23	NUM
admet-657	210	4	(	(	PUNCT
admet-657	210	5	1997	1997	NUM
admet-657	210	6	)	)	PUNCT
admet-657	210	7	3	3	NUM
admet-657	210	8	-	-	SYM
admet-657	210	9	25	25	NUM
admet-657	210	10	.	.	PUNCT
admet-657	211	1	[	[	X
admet-657	211	2	19	19	NUM
admet-657	211	3	]	]	X
admet-657	211	4	k.n	k.n	PROPN
admet-657	211	5	.	.	PROPN
admet-657	211	6	agwuh	agwuh	PROPN
admet-657	211	7	,	,	PUNCT
admet-657	211	8	a.	a.	PROPN
admet-657	211	9	macgowan	macgowan	PROPN
admet-657	211	10	.	.	PUNCT
admet-657	211	11	pharmacokinetics	pharmacokinetic	NOUN
admet-657	211	12	and	and	CCONJ
admet-657	211	13	pharmacodynamics	pharmacodynamic	NOUN
admet-657	211	14	of	of	ADP
admet-657	211	15	the	the	DET
admet-657	211	16	tetracyclines	tetracycline	NOUN
admet-657	211	17	including	include	VERB
admet-657	211	18	glycylcyclines	glycylcycline	NOUN
admet-657	211	19	.	.	PUNCT
admet-657	212	1	j.	j.	PROPN
admet-657	212	2	antimicrob	antimicrob	PROPN
admet-657	212	3	.	.	PUNCT
admet-657	213	1	chemother	chemother	PROPN
admet-657	213	2	.	.	PUNCT
admet-657	214	1	58	58	NUM
admet-657	214	2	(	(	PUNCT
admet-657	214	3	2006	2006	NUM
admet-657	214	4	)	)	PUNCT
admet-657	214	5	256	256	NUM
admet-657	214	6	-	-	SYM
admet-657	214	7	265	265	NUM
admet-657	214	8	.	.	PUNCT
admet-657	215	1	[	[	X
admet-657	215	2	20	20	NUM
admet-657	215	3	]	]	PUNCT
admet-657	215	4	f.	f.	PROPN
admet-657	215	5	assmus	assmus	PROPN
admet-657	215	6	,	,	PUNCT
admet-657	215	7	a.	a.	PROPN
admet-657	215	8	ross	ross	PROPN
admet-657	215	9	,	,	PUNCT
admet-657	215	10	h.	h.	PROPN
admet-657	215	11	fischer	fischer	PROPN
admet-657	215	12	,	,	PUNCT
admet-657	215	13	j.	j.	PROPN
admet-657	215	14	seelig	seelig	PROPN
admet-657	215	15	,	,	PUNCT
admet-657	215	16	a.	a.	NOUN
admet-657	215	17	seelig	seelig	PROPN
admet-657	215	18	.	.	PROPN
admet-657	215	19	31p	31p	PROPN
admet-657	215	20	and	and	CCONJ
admet-657	215	21	1h	1h	NUM
admet-657	215	22	nmr	nmr	NOUN
admet-657	215	23	studies	study	NOUN
admet-657	215	24	of	of	ADP
admet-657	215	25	the	the	DET
admet-657	215	26	molecular	molecular	ADJ
admet-657	215	27	organization	organization	NOUN
admet-657	215	28	of	of	ADP
admet-657	215	29	lipids	lipid	NOUN
admet-657	215	30	in	in	ADP
admet-657	215	31	the	the	DET
admet-657	215	32	parallel	parallel	ADJ
admet-657	215	33	artificial	artificial	ADJ
admet-657	215	34	membrane	membrane	NOUN
admet-657	215	35	permeability	permeability	NOUN
admet-657	215	36	assay	assay	VERB
admet-657	215	37	.	.	PUNCT
admet-657	216	1	mol	mol	X
admet-657	216	2	.	.	PUNCT
admet-657	216	3	pharm	pharm	PROPN
admet-657	216	4	.	.	PUNCT
admet-657	217	1	14	14	NUM
admet-657	217	2	(	(	PUNCT
admet-657	217	3	2016	2016	NUM
admet-657	217	4	)	)	PUNCT
admet-657	217	5	284	284	NUM
admet-657	217	6	-	-	SYM
admet-657	217	7	295	295	NUM
admet-657	217	8	.	.	PUNCT
admet-657	218	1	[	[	X
admet-657	218	2	21	21	NUM
admet-657	218	3	]	]	PUNCT
admet-657	218	4	a.	a.	NOUN
admet-657	218	5	avdeef	avdeef	PROPN
admet-657	218	6	.	.	PUNCT
admet-657	219	1	absorption	absorption	NOUN
admet-657	219	2	and	and	CCONJ
admet-657	219	3	drug	drug	NOUN
admet-657	219	4	development	development	NOUN
admet-657	219	5	:	:	PUNCT
admet-657	219	6	solubility	solubility	NOUN
admet-657	219	7	,	,	PUNCT
admet-657	219	8	permeability	permeability	NOUN
admet-657	219	9	,	,	PUNCT
admet-657	219	10	and	and	CCONJ
admet-657	219	11	charge	charge	NOUN
admet-657	219	12	state	state	NOUN
admet-657	219	13	,	,	PUNCT
admet-657	219	14	john	john	PROPN
admet-657	219	15	wiley	wiley	PROPN
admet-657	219	16	&	&	CCONJ
admet-657	219	17	sons	son	NOUN
admet-657	219	18	,	,	PUNCT
admet-657	219	19	2012	2012	NUM
admet-657	219	20	.	.	PUNCT
admet-657	220	1	[	[	X
admet-657	220	2	22	22	NUM
admet-657	220	3	]	]	PUNCT
admet-657	220	4	a.	a.	NOUN
admet-657	220	5	sigler	sigler	PROPN
admet-657	220	6	,	,	PUNCT
admet-657	220	7	p.	p.	PROPN
admet-657	220	8	schubert	schubert	PROPN
admet-657	220	9	,	,	PUNCT
admet-657	220	10	w.	w.	PROPN
admet-657	220	11	hillen	hillen	PROPN
admet-657	220	12	,	,	PUNCT
admet-657	220	13	m.	m.	PROPN
admet-657	220	14	niederweis	niederweis	PROPN
admet-657	220	15	.	.	PUNCT
admet-657	221	1	permeation	permeation	NOUN
admet-657	221	2	of	of	ADP
admet-657	221	3	tetracyclines	tetracycline	NOUN
admet-657	221	4	through	through	ADP
admet-657	221	5	membranes	membrane	NOUN
admet-657	221	6	of	of	ADP
admet-657	221	7	liposomes	liposome	NOUN
admet-657	221	8	and	and	CCONJ
admet-657	221	9	escherichia	escherichia	NOUN
admet-657	221	10	coli	coli	NOUN
admet-657	221	11	.	.	PUNCT
admet-657	222	1	eur	eur	PROPN
admet-657	222	2	.	.	PUNCT
admet-657	223	1	j.	j.	PROPN
admet-657	223	2	biochem	biochem	PROPN
admet-657	223	3	.	.	PUNCT
admet-657	224	1	267	267	NUM
admet-657	224	2	(	(	PUNCT
admet-657	224	3	2000	2000	NUM
admet-657	224	4	)	)	PUNCT
admet-657	224	5	527	527	NUM
admet-657	224	6	-	-	SYM
admet-657	224	7	534	534	NUM
admet-657	224	8	.	.	PUNCT
admet-657	225	1	[	[	X
admet-657	225	2	23	23	NUM
admet-657	225	3	]	]	X
admet-657	225	4	g.	g.	PROPN
admet-657	225	5	vizserálek	vizserálek	PROPN
admet-657	225	6	,	,	PUNCT
admet-657	225	7	t.	t.	PROPN
admet-657	225	8	balogh	balogh	PROPN
admet-657	225	9	,	,	PUNCT
admet-657	225	10	k.	k.	PROPN
admet-657	225	11	takács	takács	PROPN
admet-657	225	12	-	-	PUNCT
admet-657	225	13	novák	novák	PROPN
admet-657	225	14	,	,	PUNCT
admet-657	225	15	b.	b.	PROPN
admet-657	225	16	sinkó	sinkó	PROPN
admet-657	225	17	.	.	PUNCT
admet-657	226	1	pampa	pampa	PROPN
admet-657	226	2	study	study	NOUN
admet-657	226	3	of	of	ADP
admet-657	226	4	the	the	DET
admet-657	226	5	temperature	temperature	NOUN
admet-657	226	6	effect	effect	NOUN
admet-657	226	7	on	on	ADP
admet-657	226	8	permeability	permeability	NOUN
admet-657	226	9	.	.	PUNCT
admet-657	227	1	eur	eur	PROPN
admet-657	227	2	.	.	PUNCT
admet-657	228	1	j.	j.	PROPN
admet-657	228	2	pharm	pharm	PROPN
admet-657	228	3	.	.	PUNCT
admet-657	229	1	sci	sci	PROPN
admet-657	229	2	.	.	PROPN
admet-657	230	1	53	53	NUM
admet-657	230	2	(	(	PUNCT
admet-657	230	3	2014	2014	NUM
admet-657	230	4	)	)	PUNCT
admet-657	230	5	45	45	NUM
admet-657	230	6	-	-	SYM
admet-657	230	7	49	49	NUM
admet-657	230	8	.	.	PUNCT
admet-657	231	1	©	©	NOUN
admet-657	231	2	2019	2019	NUM
admet-657	231	3	by	by	ADP
admet-657	231	4	the	the	DET
admet-657	231	5	authors	author	NOUN
admet-657	231	6	;	;	PUNCT
admet-657	231	7	licensee	licensee	PROPN
admet-657	231	8	iapc	iapc	PROPN
admet-657	231	9	,	,	PUNCT
admet-657	231	10	zagreb	zagreb	PROPN
admet-657	231	11	,	,	PUNCT
admet-657	231	12	croatia	croatia	PROPN
admet-657	231	13	.	.	PUNCT
admet-657	232	1	this	this	DET
admet-657	232	2	article	article	NOUN
admet-657	232	3	is	be	AUX
admet-657	232	4	an	an	DET
admet-657	232	5	open	open	ADJ
admet-657	232	6	-	-	PUNCT
admet-657	232	7	access	access	NOUN
admet-657	232	8	article	article	NOUN
admet-657	232	9	distributed	distribute	VERB
admet-657	232	10	under	under	ADP
admet-657	232	11	the	the	DET
admet-657	232	12	terms	term	NOUN
admet-657	232	13	and	and	CCONJ
admet-657	232	14	conditions	condition	NOUN
admet-657	232	15	of	of	ADP
admet-657	232	16	the	the	DET
admet-657	232	17	creative	creative	ADJ
admet-657	232	18	commons	common	NOUN
admet-657	232	19	attribution	attribution	NOUN
admet-657	232	20	license	license	NOUN
admet-657	232	21	(	(	PUNCT
admet-657	232	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-657	232	23	)	)	PUNCT
admet-657	232	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN