id	sid	tid	token	lemma	pos
admet-661	1	1	investigation	investigation	NOUN
admet-661	1	2	of	of	ADP
admet-661	1	3	possible	possible	ADJ
admet-661	1	4	solubility	solubility	NOUN
admet-661	1	5	and	and	CCONJ
admet-661	1	6	dissolution	dissolution	NOUN
admet-661	1	7	advantages	advantage	NOUN
admet-661	1	8	of	of	ADP
admet-661	1	9	cocrystals	cocrystal	NOUN
admet-661	1	10	,	,	PUNCT
admet-661	1	11	i	i	PRON
admet-661	1	12	:	:	PUNCT
admet-661	1	13	aqueous	aqueous	ADJ
admet-661	1	14	solubility	solubility	NOUN
admet-661	1	15	and	and	CCONJ
admet-661	1	16	dissolution	dissolution	NOUN
admet-661	1	17	rates	rate	NOUN
admet-661	1	18	of	of	ADP
admet-661	1	19	ketoconazole	ketoconazole	NOUN
admet-661	1	20	and	and	CCONJ
admet-661	1	21	its	its	PRON
admet-661	1	22	cocrystals	cocrystal	NOUN
admet-661	1	23	as	as	ADP
admet-661	1	24	functions	function	NOUN
admet-661	1	25	of	of	ADP
admet-661	1	26	ph	ph	ADJ
admet-661	1	27	doi	doi	NOUN
admet-661	1	28	:	:	PUNCT
admet-661	1	29	10.5599	10.5599	NUM
admet-661	1	30	/	/	SYM
admet-661	1	31	admet.661	admet.661	PROPN
admet-661	1	32	106	106	NUM
admet-661	1	33	admet	admet	PROPN
admet-661	1	34	&	&	CCONJ
admet-661	1	35	dmpk	dmpk	PROPN
admet-661	1	36	7(2	7(2	NUM
admet-661	1	37	)	)	PUNCT
admet-661	1	38	(	(	PUNCT
admet-661	1	39	2019	2019	NUM
admet-661	1	40	)	)	PUNCT
admet-661	1	41	106	106	NUM
admet-661	1	42	-	-	SYM
admet-661	1	43	130	130	NUM
admet-661	1	44	;	;	PUNCT
admet-661	1	45	doi	doi	NOUN
admet-661	1	46	:	:	PUNCT
admet-661	1	47	http://dx.doi.org/10.5599/admet.661	http://dx.doi.org/10.5599/admet.661	ADJ
admet-661	1	48	open	open	ADJ
admet-661	1	49	access	access	NOUN
admet-661	1	50	:	:	PUNCT
admet-661	1	51	issn	issn	PROPN
admet-661	1	52	:	:	PUNCT
admet-661	1	53	1848	1848	NUM
admet-661	1	54	-	-	SYM
admet-661	1	55	7718	7718	NUM
admet-661	1	56	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-661	1	57	original	original	ADJ
admet-661	1	58	scientific	scientific	ADJ
admet-661	1	59	paper	paper	NOUN
admet-661	1	60	investigation	investigation	NOUN
admet-661	1	61	of	of	ADP
admet-661	1	62	possible	possible	ADJ
admet-661	1	63	solubility	solubility	NOUN
admet-661	1	64	and	and	CCONJ
admet-661	1	65	dissolution	dissolution	NOUN
admet-661	1	66	advantages	advantage	NOUN
admet-661	1	67	of	of	ADP
admet-661	1	68	cocrystals	cocrystal	NOUN
admet-661	1	69	,	,	PUNCT
admet-661	1	70	i	i	PRON
admet-661	1	71	:	:	PUNCT
admet-661	1	72	aqueous	aqueous	ADJ
admet-661	1	73	solubility	solubility	NOUN
admet-661	1	74	and	and	CCONJ
admet-661	1	75	dissolution	dissolution	NOUN
admet-661	1	76	rates	rate	NOUN
admet-661	1	77	of	of	ADP
admet-661	1	78	ketoconazole	ketoconazole	NOUN
admet-661	1	79	and	and	CCONJ
admet-661	1	80	its	its	PRON
admet-661	1	81	cocrystals	cocrystal	NOUN
admet-661	1	82	as	as	ADP
admet-661	1	83	functions	function	NOUN
admet-661	1	84	of	of	ADP
admet-661	1	85	ph	ph	ADJ
admet-661	1	86	jaydip	jaydip	ADJ
admet-661	1	87	m.	m.	NOUN
admet-661	1	88	vasoya,1	vasoya,1	X
admet-661	1	89	ankita	ankita	VERB
admet-661	1	90	v.	v.	ADP
admet-661	1	91	shah,1,2	shah,1,2	PROPN
admet-661	1	92	abu	abu	PROPN
admet-661	1	93	t.m	t.m	PROPN
admet-661	1	94	.	.	PUNCT
admet-661	1	95	serajuddin1	serajuddin1	PROPN
admet-661	1	96	,	,	PUNCT
admet-661	1	97	*	*	SYM
admet-661	1	98	1	1	NUM
admet-661	1	99	department	department	NOUN
admet-661	1	100	of	of	ADP
admet-661	1	101	pharmaceutical	pharmaceutical	NOUN
admet-661	1	102	sciences	science	NOUN
admet-661	1	103	,	,	PUNCT
admet-661	1	104	college	college	NOUN
admet-661	1	105	of	of	ADP
admet-661	1	106	pharmacy	pharmacy	NOUN
admet-661	1	107	and	and	CCONJ
admet-661	1	108	health	health	NOUN
admet-661	1	109	sciences	sciences	PROPN
admet-661	1	110	,	,	PUNCT
admet-661	1	111	st	st	PROPN
admet-661	1	112	.	.	PROPN
admet-661	1	113	john	john	PROPN
admet-661	1	114	’s	’s	PROPN
admet-661	1	115	university	university	PROPN
admet-661	1	116	,	,	PUNCT
admet-661	1	117	8000	8000	NUM
admet-661	1	118	utopia	utopia	NOUN
admet-661	1	119	parkway	parkway	PROPN
admet-661	1	120	,	,	PUNCT
admet-661	1	121	queens	queen	NOUN
admet-661	1	122	,	,	PUNCT
admet-661	1	123	ny	ny	PROPN
admet-661	1	124	11439	11439	NUM
admet-661	1	125	,	,	PUNCT
admet-661	1	126	usa	usa	PROPN
admet-661	1	127	(	(	PUNCT
admet-661	1	128	jaydip	jaydip	ADJ
admet-661	1	129	m.	m.	NOUN
admet-661	1	130	vasoya	vasoya	PROPN
admet-661	1	131	:	:	PUNCT
admet-661	1	132	jaydip.vasoya15@stjohns.edu	jaydip.vasoya15@stjohns.edu	PROPN
admet-661	1	133	)	)	PUNCT
admet-661	1	134	2	2	NUM
admet-661	1	135	current	current	ADJ
admet-661	1	136	address	address	NOUN
admet-661	1	137	:	:	PUNCT
admet-661	1	138	freund	freund	ADJ
admet-661	1	139	-	-	PUNCT
admet-661	1	140	vector	vector	NOUN
admet-661	1	141	corporation	corporation	NOUN
admet-661	1	142	,	,	PUNCT
admet-661	1	143	675	675	NUM
admet-661	1	144	44	44	NUM
admet-661	1	145	th	th	NUM
admet-661	1	146	street	street	NOUN
admet-661	1	147	,	,	PUNCT
admet-661	1	148	marion	marion	PROPN
admet-661	1	149	,	,	PUNCT
admet-661	1	150	ia	ia	PROPN
admet-661	1	151	52302	52302	NUM
admet-661	1	152	,	,	PUNCT
admet-661	1	153	usa	usa	PROPN
admet-661	1	154	(	(	PUNCT
admet-661	1	155	ankita	ankita	PROPN
admet-661	1	156	v	v	ADP
admet-661	1	157	shah	shah	NOUN
admet-661	1	158	:	:	PUNCT
admet-661	1	159	ankita.shah@freund-vector.com	ankita.shah@freund-vector.com	X
admet-661	1	160	)	)	PUNCT
admet-661	1	161	*	*	PUNCT
admet-661	2	1	corresponding	correspond	VERB
admet-661	2	2	author	author	NOUN
admet-661	2	3	:	:	PUNCT
admet-661	2	4	dr	dr	PROPN
admet-661	2	5	.	.	PROPN
admet-661	3	1	abu	abu	PROPN
admet-661	3	2	t.m	t.m	PROPN
admet-661	3	3	.	.	PUNCT
admet-661	3	4	serajuddin	serajuddin	PROPN
admet-661	3	5	,	,	PUNCT
admet-661	3	6	email	email	NOUN
admet-661	3	7	:	:	PUNCT
admet-661	3	8	serajuda@stjohns.edu	serajuda@stjohns.edu	PROPN
admet-661	3	9	,	,	PUNCT
admet-661	3	10	office	office	NOUN
admet-661	3	11	phone	phone	NOUN
admet-661	3	12	:	:	PUNCT
admet-661	3	13	718	718	NUM
admet-661	3	14	-	-	SYM
admet-661	3	15	990	990	NUM
admet-661	3	16	-	-	PUNCT
admet-661	3	17	7822	7822	NUM
admet-661	3	18	received	receive	VERB
admet-661	3	19	:	:	PUNCT
admet-661	3	20	february	february	PROPN
admet-661	3	21	04	04	NUM
admet-661	3	22	,	,	PUNCT
admet-661	3	23	2019	2019	NUM
admet-661	3	24	;	;	PUNCT
admet-661	3	25	revised	revise	VERB
admet-661	3	26	:	:	PUNCT
admet-661	3	27	april	april	PROPN
admet-661	3	28	01	01	NUM
admet-661	3	29	,	,	PUNCT
admet-661	3	30	2019	2019	NUM
admet-661	3	31	;	;	PUNCT
admet-661	3	32	published	publish	VERB
admet-661	3	33	:	:	PUNCT
admet-661	3	34	april	april	PROPN
admet-661	3	35	05	05	NUM
admet-661	3	36	,	,	PUNCT
admet-661	3	37	2019	2019	NUM
admet-661	3	38	abstract	abstract	ADV
admet-661	3	39	since	since	SCONJ
admet-661	3	40	there	there	PRON
admet-661	3	41	are	be	VERB
admet-661	3	42	conflicting	conflicting	ADJ
admet-661	3	43	reports	report	NOUN
admet-661	3	44	in	in	ADP
admet-661	3	45	the	the	DET
admet-661	3	46	literature	literature	NOUN
admet-661	3	47	on	on	ADP
admet-661	3	48	solubility	solubility	NOUN
admet-661	3	49	and	and	CCONJ
admet-661	3	50	dissolution	dissolution	NOUN
admet-661	3	51	advantages	advantage	NOUN
admet-661	3	52	of	of	ADP
admet-661	3	53	cocrystals	cocrystal	NOUN
admet-661	3	54	over	over	ADP
admet-661	3	55	free	free	ADJ
admet-661	3	56	forms	form	NOUN
admet-661	3	57	,	,	PUNCT
admet-661	3	58	we	we	PRON
admet-661	3	59	systematically	systematically	ADV
admet-661	3	60	studied	study	VERB
admet-661	3	61	solubility	solubility	NOUN
admet-661	3	62	and	and	CCONJ
admet-661	3	63	intrinsic	intrinsic	ADJ
admet-661	3	64	dissolution	dissolution	NOUN
admet-661	3	65	rates	rate	NOUN
admet-661	3	66	of	of	ADP
admet-661	3	67	a	a	DET
admet-661	3	68	weakly	weakly	ADJ
admet-661	3	69	basic	basic	ADJ
admet-661	3	70	drug	drug	NOUN
admet-661	3	71	,	,	PUNCT
admet-661	3	72	ketoconazole	ketoconazole	NOUN
admet-661	3	73	,	,	PUNCT
admet-661	3	74	and	and	CCONJ
admet-661	3	75	its	its	PRON
admet-661	3	76	cocrystals	cocrystal	NOUN
admet-661	3	77	with	with	ADP
admet-661	3	78	fumaric	fumaric	ADJ
admet-661	3	79	acid	acid	PROPN
admet-661	3	80	and	and	CCONJ
admet-661	3	81	succinic	succinic	ADJ
admet-661	3	82	acid	acid	NOUN
admet-661	3	83	as	as	ADP
admet-661	3	84	functions	function	NOUN
admet-661	3	85	of	of	ADP
admet-661	3	86	ph	ph	NOUN
admet-661	3	87	to	to	PART
admet-661	3	88	determine	determine	VERB
admet-661	3	89	what	what	DET
admet-661	3	90	advantages	advantage	NOUN
admet-661	3	91	cocrystals	cocrystal	NOUN
admet-661	3	92	provide	provide	VERB
admet-661	3	93	.	.	PUNCT
admet-661	4	1	ph	ph	ADJ
admet-661	4	2	-	-	PUNCT
admet-661	4	3	solubility	solubility	NOUN
admet-661	4	4	profiles	profile	NOUN
admet-661	4	5	were	be	AUX
admet-661	4	6	determined	determine	VERB
admet-661	4	7	in	in	ADP
admet-661	4	8	two	two	NUM
admet-661	4	9	different	different	ADJ
admet-661	4	10	ways	way	NOUN
admet-661	4	11	:	:	PUNCT
admet-661	4	12	one	one	NUM
admet-661	4	13	by	by	ADP
admet-661	4	14	lowering	lower	VERB
admet-661	4	15	ph	ph	NOUN
admet-661	4	16	of	of	ADP
admet-661	4	17	ketoconazole	ketoconazole	NOUN
admet-661	4	18	aqueous	aqueous	ADJ
admet-661	4	19	suspensions	suspension	NOUN
admet-661	4	20	using	use	VERB
admet-661	4	21	hcl	hcl	PROPN
admet-661	4	22	,	,	PUNCT
admet-661	4	23	fumaric	fumaric	ADJ
admet-661	4	24	acid	acid	PROPN
admet-661	4	25	and	and	CCONJ
admet-661	4	26	succinic	succinic	ADJ
admet-661	4	27	acid	acid	NOUN
admet-661	4	28	,	,	PUNCT
admet-661	4	29	and	and	CCONJ
admet-661	4	30	the	the	DET
admet-661	4	31	other	other	ADJ
admet-661	4	32	by	by	ADP
admet-661	4	33	adjusting	adjust	VERB
admet-661	4	34	ph	ph	NOUN
admet-661	4	35	of	of	ADP
admet-661	4	36	cocrystal	cocrystal	ADJ
admet-661	4	37	suspensions	suspension	NOUN
admet-661	4	38	using	use	VERB
admet-661	4	39	respective	respective	ADJ
admet-661	4	40	coformer	coformer	NOUN
admet-661	4	41	acids	acid	NOUN
admet-661	4	42	or	or	CCONJ
admet-661	4	43	naoh	naoh	NOUN
admet-661	4	44	.	.	PUNCT
admet-661	5	1	similar	similar	ADJ
admet-661	5	2	ph	ph	ADJ
admet-661	5	3	-	-	PUNCT
admet-661	5	4	solubility	solubility	NOUN
admet-661	5	5	profiles	profile	NOUN
admet-661	5	6	were	be	AUX
admet-661	5	7	obtained	obtain	VERB
admet-661	5	8	whether	whether	SCONJ
admet-661	5	9	free	free	ADJ
admet-661	5	10	base	base	NOUN
admet-661	5	11	or	or	CCONJ
admet-661	5	12	cocrystals	cocrystal	NOUN
admet-661	5	13	were	be	AUX
admet-661	5	14	used	use	VERB
admet-661	5	15	as	as	ADP
admet-661	5	16	starting	start	VERB
admet-661	5	17	materials	material	NOUN
admet-661	5	18	to	to	PART
admet-661	5	19	determine	determine	VERB
admet-661	5	20	solubility	solubility	NOUN
admet-661	5	21	.	.	PUNCT
admet-661	6	1	with	with	ADP
admet-661	6	2	the	the	DET
admet-661	6	3	addition	addition	NOUN
admet-661	6	4	of	of	ADP
admet-661	6	5	fumaric	fumaric	ADJ
admet-661	6	6	and	and	CCONJ
admet-661	6	7	succinic	succinic	ADJ
admet-661	6	8	acids	acid	NOUN
admet-661	6	9	to	to	ADP
admet-661	6	10	aqueous	aqueous	ADJ
admet-661	6	11	suspensions	suspension	NOUN
admet-661	6	12	of	of	ADP
admet-661	6	13	free	free	ADJ
admet-661	6	14	base	base	NOUN
admet-661	6	15	to	to	PART
admet-661	6	16	lower	low	ADJ
admet-661	6	17	ph	ph	VERB
admet-661	6	18	,	,	PUNCT
admet-661	6	19	the	the	DET
admet-661	6	20	maximum	maximum	ADJ
admet-661	6	21	solubility	solubility	NOUN
admet-661	6	22	(	(	PUNCT
admet-661	6	23	phmax	phmax	VERB
admet-661	6	24	)	)	PUNCT
admet-661	6	25	was	be	AUX
admet-661	6	26	reached	reach	VERB
admet-661	6	27	at	at	ADP
admet-661	6	28	ph	ph	PROPN
admet-661	6	29	~3.5	~3.5	PROPN
admet-661	6	30	-	-	SYM
admet-661	6	31	4.0	4.0	NUM
admet-661	6	32	,	,	PUNCT
admet-661	6	33	below	below	ADP
admet-661	6	34	which	which	PRON
admet-661	6	35	the	the	DET
admet-661	6	36	solubility	solubility	NOUN
admet-661	6	37	decreased	decrease	VERB
admet-661	6	38	and	and	CCONJ
admet-661	6	39	cocrystals	cocrystal	NOUN
admet-661	6	40	formed	form	VERB
admet-661	6	41	.	.	PUNCT
admet-661	7	1	the	the	DET
admet-661	7	2	solubility	solubility	NOUN
admet-661	7	3	,	,	PUNCT
admet-661	7	4	however	however	ADV
admet-661	7	5	,	,	PUNCT
admet-661	7	6	continued	continued	ADJ
admet-661	7	7	increasing	increase	VERB
admet-661	7	8	when	when	SCONJ
admet-661	7	9	hcl	hcl	PROPN
admet-661	7	10	was	be	AUX
admet-661	7	11	added	add	VERB
admet-661	7	12	to	to	ADP
admet-661	7	13	ketoconazole	ketoconazole	PROPN
admet-661	7	14	suspension	suspension	NOUN
admet-661	7	15	as	as	SCONJ
admet-661	7	16	no	no	DET
admet-661	7	17	cocrystal	cocrystal	ADJ
admet-661	7	18	or	or	CCONJ
admet-661	7	19	salt	salt	NOUN
admet-661	7	20	was	be	AUX
admet-661	7	21	formed	form	VERB
admet-661	7	22	.	.	PUNCT
admet-661	8	1	during	during	ADP
admet-661	8	2	determination	determination	NOUN
admet-661	8	3	of	of	ADP
admet-661	8	4	cocrystal	cocrystal	ADJ
admet-661	8	5	solubility	solubility	PROPN
admet-661	8	6	,	,	PUNCT
admet-661	8	7	a	a	DET
admet-661	8	8	conversion	conversion	NOUN
admet-661	8	9	to	to	ADP
admet-661	8	10	free	free	ADJ
admet-661	8	11	base	base	NOUN
admet-661	8	12	was	be	AUX
admet-661	8	13	observed	observe	VERB
admet-661	8	14	when	when	SCONJ
admet-661	8	15	ph	ph	PROPN
admet-661	8	16	was	be	AUX
admet-661	8	17	raised	raise	VERB
admet-661	8	18	above	above	ADP
admet-661	8	19	phmax	phmax	NOUN
admet-661	8	20	.	.	PUNCT
admet-661	9	1	thus	thus	ADV
admet-661	9	2	,	,	PUNCT
admet-661	9	3	ph	ph	ADJ
admet-661	9	4	-	-	PUNCT
admet-661	9	5	solubility	solubility	NOUN
admet-661	9	6	profiles	profile	NOUN
admet-661	9	7	of	of	ADP
admet-661	9	8	cocrystals	cocrystal	NOUN
admet-661	9	9	resembled	resemble	VERB
admet-661	9	10	solubility	solubility	NOUN
admet-661	9	11	profiles	profile	NOUN
admet-661	9	12	commonly	commonly	ADV
admet-661	9	13	encountered	encounter	VERB
admet-661	9	14	with	with	ADP
admet-661	9	15	salts	salt	NOUN
admet-661	9	16	.	.	PUNCT
admet-661	10	1	above	above	ADP
admet-661	10	2	phmax	phmax	NOUN
admet-661	10	3	,	,	PUNCT
admet-661	10	4	both	both	DET
admet-661	10	5	free	free	ADJ
admet-661	10	6	base	base	NOUN
admet-661	10	7	and	and	CCONJ
admet-661	10	8	cocrystal	cocrystal	NOUN
admet-661	10	9	had	have	VERB
admet-661	10	10	similar	similar	ADJ
admet-661	10	11	solubility	solubility	NOUN
admet-661	10	12	under	under	ADP
admet-661	10	13	identical	identical	ADJ
admet-661	10	14	ph	ph	ADJ
admet-661	10	15	conditions	condition	NOUN
admet-661	10	16	;	;	PUNCT
admet-661	10	17	the	the	DET
admet-661	10	18	solubility	solubility	NOUN
admet-661	10	19	of	of	ADP
admet-661	10	20	cocrystal	cocrystal	PROPN
admet-661	10	21	was	be	AUX
admet-661	10	22	higher	high	ADJ
admet-661	10	23	only	only	ADV
admet-661	10	24	if	if	SCONJ
admet-661	10	25	the	the	DET
admet-661	10	26	ph	ph	NOUN
admet-661	10	27	differed	differ	VERB
admet-661	10	28	.	.	PUNCT
admet-661	11	1	in	in	ADP
admet-661	11	2	contrast	contrast	NOUN
admet-661	11	3	,	,	PUNCT
admet-661	11	4	intrinsic	intrinsic	ADJ
admet-661	11	5	dissolution	dissolution	NOUN
admet-661	11	6	rates	rate	NOUN
admet-661	11	7	of	of	ADP
admet-661	11	8	cocrystals	cocrystal	NOUN
admet-661	11	9	at	at	ADP
admet-661	11	10	ph	ph	PROPN
admet-661	11	11	>	>	X
admet-661	11	12	phmax	phmax	X
admet-661	11	13	under	under	ADP
admet-661	11	14	identical	identical	ADJ
admet-661	11	15	bulk	bulk	ADJ
admet-661	11	16	ph	ph	NOUN
admet-661	11	17	were	be	AUX
admet-661	11	18	much	much	ADV
admet-661	11	19	higher	high	ADJ
admet-661	11	20	than	than	ADP
admet-661	11	21	that	that	PRON
admet-661	11	22	of	of	ADP
admet-661	11	23	free	free	ADJ
admet-661	11	24	ketoconazole	ketoconazole	NOUN
admet-661	11	25	since	since	SCONJ
admet-661	11	26	cocrystals	cocrystal	NOUN
admet-661	11	27	had	have	VERB
admet-661	11	28	lower	low	ADJ
admet-661	11	29	microenvironmental	microenvironmental	ADJ
admet-661	11	30	ph	ph	NOUN
admet-661	11	31	at	at	ADP
admet-661	11	32	the	the	DET
admet-661	11	33	dissolving	dissolve	VERB
admet-661	11	34	surface	surface	NOUN
admet-661	11	35	,	,	PUNCT
admet-661	11	36	where	where	SCONJ
admet-661	11	37	the	the	DET
admet-661	11	38	solubility	solubility	NOUN
admet-661	11	39	was	be	AUX
admet-661	11	40	high	high	ADJ
admet-661	11	41	.	.	PUNCT
admet-661	12	1	thus	thus	ADV
admet-661	12	2	,	,	PUNCT
admet-661	12	3	cocrystals	cocrystal	NOUN
admet-661	12	4	of	of	ADP
admet-661	12	5	basic	basic	ADJ
admet-661	12	6	drugs	drug	NOUN
admet-661	12	7	can	can	AUX
admet-661	12	8	potentially	potentially	ADV
admet-661	12	9	provide	provide	VERB
admet-661	12	10	higher	high	ADJ
admet-661	12	11	dissolution	dissolution	NOUN
admet-661	12	12	rates	rate	NOUN
admet-661	12	13	under	under	ADP
admet-661	12	14	intestinal	intestinal	ADJ
admet-661	12	15	ph	ph	ADJ
admet-661	12	16	conditions	condition	NOUN
admet-661	12	17	.	.	PUNCT
admet-661	13	1	keywords	keyword	VERB
admet-661	13	2	ketoconazole	ketoconazole	NOUN
admet-661	13	3	;	;	PUNCT
admet-661	13	4	cocrystal	cocrystal	PROPN
admet-661	13	5	;	;	PUNCT
admet-661	13	6	solubility	solubility	NOUN
admet-661	13	7	;	;	PUNCT
admet-661	13	8	ph	ph	ADJ
admet-661	13	9	effect	effect	NOUN
admet-661	13	10	;	;	PUNCT
admet-661	13	11	intrinsic	intrinsic	ADJ
admet-661	13	12	dissolution	dissolution	NOUN
admet-661	13	13	rate	rate	NOUN
admet-661	13	14	;	;	PUNCT
admet-661	13	15	solid	solid	ADJ
admet-661	13	16	phase	phase	NOUN
admet-661	13	17	;	;	PUNCT
admet-661	13	18	phase	phase	NOUN
admet-661	13	19	conversion	conversion	NOUN
admet-661	13	20	introduction	introduction	NOUN
admet-661	13	21	crystalline	crystalline	NOUN
admet-661	13	22	forms	form	NOUN
admet-661	13	23	of	of	ADP
admet-661	13	24	acidic	acidic	ADJ
admet-661	13	25	and	and	CCONJ
admet-661	13	26	basic	basic	ADJ
admet-661	13	27	drugs	drug	NOUN
admet-661	13	28	or	or	CCONJ
admet-661	13	29	their	their	PRON
admet-661	13	30	salts	salt	NOUN
admet-661	13	31	have	have	AUX
admet-661	13	32	traditionally	traditionally	ADV
admet-661	13	33	been	be	AUX
admet-661	13	34	used	use	VERB
admet-661	13	35	as	as	ADP
admet-661	13	36	active	active	ADJ
admet-661	13	37	pharmaceutical	pharmaceutical	ADJ
admet-661	13	38	ingredients	ingredient	NOUN
admet-661	13	39	(	(	PUNCT
admet-661	13	40	api	api	NOUN
admet-661	13	41	)	)	PUNCT
admet-661	14	1	[	[	X
admet-661	14	2	1	1	NUM
admet-661	14	3	]	]	PUNCT
admet-661	14	4	.	.	PUNCT
admet-661	15	1	during	during	ADP
admet-661	15	2	the	the	DET
admet-661	15	3	past	past	ADJ
admet-661	15	4	two	two	NUM
admet-661	15	5	decades	decade	NOUN
admet-661	15	6	,	,	PUNCT
admet-661	15	7	cocrystal	cocrystal	PROPN
admet-661	15	8	,	,	PUNCT
admet-661	15	9	which	which	PRON
admet-661	15	10	is	be	AUX
admet-661	15	11	another	another	DET
admet-661	15	12	class	class	NOUN
admet-661	15	13	of	of	ADP
admet-661	15	14	crystalline	crystalline	NOUN
admet-661	15	15	drug	drug	NOUN
admet-661	15	16	substance	substance	NOUN
admet-661	15	17	,	,	PUNCT
admet-661	15	18	has	have	AUX
admet-661	15	19	gained	gain	VERB
admet-661	15	20	much	much	ADJ
admet-661	15	21	interest	interest	NOUN
admet-661	15	22	in	in	ADP
admet-661	15	23	the	the	DET
admet-661	15	24	pharmaceutical	pharmaceutical	ADJ
admet-661	15	25	field	field	NOUN
admet-661	15	26	for	for	ADP
admet-661	15	27	potential	potential	ADJ
admet-661	15	28	development	development	NOUN
admet-661	15	29	as	as	ADP
admet-661	15	30	api	api	NOUN
admet-661	15	31	[	[	X
admet-661	15	32	2	2	NUM
admet-661	15	33	-	-	SYM
admet-661	15	34	5	5	NUM
admet-661	15	35	]	]	PUNCT
admet-661	15	36	.	.	PUNCT
admet-661	16	1	the	the	DET
admet-661	16	2	us	us	PROPN
admet-661	16	3	food	food	NOUN
admet-661	16	4	and	and	CCONJ
admet-661	16	5	drug	drug	PROPN
admet-661	16	6	administration	administration	PROPN
admet-661	16	7	(	(	PUNCT
admet-661	16	8	fda	fda	PROPN
admet-661	16	9	)	)	PUNCT
admet-661	16	10	defined	define	VERB
admet-661	16	11	cocrystals	cocrystal	NOUN
admet-661	16	12	as	as	ADP
admet-661	16	13	“	"	PUNCT
admet-661	16	14	crystalline	crystalline	ADJ
admet-661	16	15	materials	material	NOUN
admet-661	16	16	composed	compose	VERB
admet-661	16	17	of	of	ADP
admet-661	16	18	two	two	NUM
admet-661	16	19	or	or	CCONJ
admet-661	16	20	more	more	ADV
admet-661	16	21	different	different	ADJ
admet-661	16	22	molecules	molecule	NOUN
admet-661	16	23	,	,	PUNCT
admet-661	16	24	typically	typically	ADV
admet-661	16	25	active	active	ADJ
admet-661	16	26	pharmaceutical	pharmaceutical	ADJ
admet-661	16	27	ingredient	ingredient	NOUN
admet-661	16	28	(	(	PUNCT
admet-661	16	29	api	api	NOUN
admet-661	16	30	)	)	PUNCT
admet-661	16	31	and	and	CCONJ
admet-661	16	32	cohttp://www.pub.iapchem.org/ojs/index.php/admet/index	cohttp://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-661	16	33	mailto:jaydip.vasoya15@stjohns.edu	mailto:jaydip.vasoya15@stjohns.edu	PROPN
admet-661	16	34	mailto:serajuda@stjohns.edu	mailto:serajuda@stjohns.edu	PROPN
admet-661	16	35	admet	admet	PROPN
admet-661	16	36	&	&	CCONJ
admet-661	16	37	dmpk	dmpk	PROPN
admet-661	16	38	7(2	7(2	NUM
admet-661	16	39	)	)	PUNCT
admet-661	16	40	(	(	PUNCT
admet-661	16	41	2019	2019	NUM
admet-661	16	42	)	)	PUNCT
admet-661	16	43	106	106	NUM
admet-661	16	44	-	-	SYM
admet-661	16	45	130	130	NUM
admet-661	16	46	solubility	solubility	NOUN
admet-661	16	47	and	and	CCONJ
admet-661	16	48	dissolution	dissolution	NOUN
admet-661	16	49	of	of	ADP
admet-661	16	50	cocrystals	cocrystal	NOUN
admet-661	16	51	doi	doi	NOUN
admet-661	16	52	:	:	PUNCT
admet-661	16	53	10.5599	10.5599	NUM
admet-661	16	54	/	/	SYM
admet-661	16	55	admet.661	admet.661	PROPN
admet-661	16	56	107	107	NUM
admet-661	16	57	crystal	crystal	NOUN
admet-661	16	58	formers	former	NOUN
admet-661	16	59	(	(	PUNCT
admet-661	16	60	‘	'	PUNCT
admet-661	16	61	coformers	coformer	NOUN
admet-661	16	62	’	'	PUNCT
admet-661	16	63	)	)	PUNCT
admet-661	16	64	,	,	PUNCT
admet-661	16	65	in	in	ADP
admet-661	16	66	the	the	DET
admet-661	16	67	same	same	ADJ
admet-661	16	68	crystal	crystal	NOUN
admet-661	16	69	lattice	lattice	NOUN
admet-661	16	70	”	"	PUNCT
admet-661	16	71	[	[	X
admet-661	16	72	6	6	NUM
admet-661	16	73	]	]	PUNCT
admet-661	16	74	.	.	PUNCT
admet-661	17	1	to	to	PART
admet-661	17	2	exclude	exclude	VERB
admet-661	17	3	solvate	solvate	NOUN
admet-661	17	4	,	,	PUNCT
admet-661	17	5	hydrate	hydrate	NOUN
admet-661	17	6	,	,	PUNCT
admet-661	17	7	salt	salt	NOUN
admet-661	17	8	,	,	PUNCT
admet-661	17	9	etc	etc	X
admet-661	17	10	.	.	X
admet-661	17	11	,	,	PUNCT
admet-661	17	12	from	from	ADP
admet-661	17	13	such	such	DET
admet-661	17	14	a	a	DET
admet-661	17	15	definition	definition	NOUN
admet-661	17	16	,	,	PUNCT
admet-661	17	17	an	an	DET
admet-661	17	18	international	international	ADJ
admet-661	17	19	panel	panel	NOUN
admet-661	17	20	of	of	ADP
admet-661	17	21	experts	expert	NOUN
admet-661	17	22	defined	define	VERB
admet-661	17	23	cocrystals	cocrystal	NOUN
admet-661	17	24	as	as	ADP
admet-661	17	25	“	"	PUNCT
admet-661	17	26	solids	solid	NOUN
admet-661	17	27	that	that	PRON
admet-661	17	28	are	be	AUX
admet-661	17	29	crystalline	crystalline	ADJ
admet-661	17	30	singlephase	singlephase	NOUN
admet-661	17	31	materials	material	NOUN
admet-661	17	32	composed	compose	VERB
admet-661	17	33	of	of	ADP
admet-661	17	34	two	two	NUM
admet-661	17	35	or	or	CCONJ
admet-661	17	36	more	more	ADV
admet-661	17	37	different	different	ADJ
admet-661	17	38	molecular	molecular	ADJ
admet-661	17	39	and	and	CCONJ
admet-661	17	40	ionic	ionic	ADJ
admet-661	17	41	compounds	compound	NOUN
admet-661	17	42	generally	generally	ADV
admet-661	17	43	in	in	ADP
admet-661	17	44	a	a	DET
admet-661	17	45	stoichiometric	stoichiometric	ADJ
admet-661	17	46	ratio	ratio	NOUN
admet-661	17	47	,	,	PUNCT
admet-661	17	48	which	which	PRON
admet-661	17	49	are	be	AUX
admet-661	17	50	neither	neither	CCONJ
admet-661	17	51	solvates	solvate	NOUN
admet-661	17	52	nor	nor	CCONJ
admet-661	17	53	simple	simple	ADJ
admet-661	17	54	salts	salt	NOUN
admet-661	17	55	”	"	PUNCT
admet-661	18	1	[	[	X
admet-661	18	2	7	7	NUM
admet-661	18	3	]	]	PUNCT
admet-661	18	4	.	.	PUNCT
admet-661	19	1	the	the	DET
admet-661	19	2	cocrystals	cocrystal	NOUN
admet-661	19	3	differ	differ	VERB
admet-661	19	4	from	from	ADP
admet-661	19	5	salts	salt	NOUN
admet-661	19	6	as	as	SCONJ
admet-661	19	7	no	no	DET
admet-661	19	8	acid	acid	NOUN
admet-661	19	9	-	-	PUNCT
admet-661	19	10	base	base	NOUN
admet-661	19	11	proton	proton	NOUN
admet-661	19	12	transfers	transfer	NOUN
admet-661	19	13	are	be	AUX
admet-661	19	14	involved	involve	VERB
admet-661	19	15	in	in	ADP
admet-661	19	16	cocrystal	cocrystal	ADJ
admet-661	19	17	formation	formation	NOUN
admet-661	19	18	.	.	PUNCT
admet-661	20	1	they	they	PRON
admet-661	20	2	are	be	AUX
admet-661	20	3	usually	usually	ADV
admet-661	20	4	formed	form	VERB
admet-661	20	5	by	by	ADP
admet-661	20	6	hydrogen	hydrogen	NOUN
admet-661	20	7	bonding	bonding	NOUN
admet-661	20	8	or	or	CCONJ
admet-661	20	9	other	other	ADJ
admet-661	20	10	electrostatic	electrostatic	ADJ
admet-661	20	11	interactions	interaction	NOUN
admet-661	20	12	like	like	ADP
admet-661	20	13	π	π	PROPN
admet-661	20	14	-	-	PROPN
admet-661	20	15	π	π	PROPN
admet-661	20	16	interaction	interaction	NOUN
admet-661	20	17	,	,	PUNCT
admet-661	20	18	halogen	halogen	NOUN
admet-661	20	19	bonding	bonding	NOUN
admet-661	20	20	,	,	PUNCT
admet-661	20	21	etc	etc	X
admet-661	20	22	.	.	X
admet-661	20	23	,	,	PUNCT
admet-661	20	24	between	between	ADP
admet-661	20	25	two	two	NUM
admet-661	20	26	species	specie	NOUN
admet-661	20	27	,	,	PUNCT
admet-661	20	28	and	and	CCONJ
admet-661	20	29	,	,	PUNCT
admet-661	20	30	thus	thus	ADV
admet-661	20	31	,	,	PUNCT
admet-661	20	32	cocrystals	cocrystal	NOUN
admet-661	20	33	may	may	AUX
admet-661	20	34	form	form	VERB
admet-661	20	35	even	even	ADV
admet-661	20	36	between	between	ADP
admet-661	20	37	neutral	neutral	ADJ
admet-661	20	38	molecules	molecule	NOUN
admet-661	20	39	[	[	X
admet-661	20	40	8	8	NUM
admet-661	20	41	]	]	PUNCT
admet-661	20	42	.	.	PUNCT
admet-661	21	1	it	it	PRON
admet-661	21	2	is	be	AUX
admet-661	21	3	believed	believe	VERB
admet-661	21	4	that	that	SCONJ
admet-661	21	5	cocrystals	cocrystal	NOUN
admet-661	21	6	dissociate	dissociate	VERB
admet-661	21	7	into	into	ADP
admet-661	21	8	individual	individual	ADJ
admet-661	21	9	molecular	molecular	ADJ
admet-661	21	10	species	specie	NOUN
admet-661	21	11	when	when	SCONJ
admet-661	21	12	they	they	PRON
admet-661	21	13	dissolve	dissolve	VERB
admet-661	21	14	in	in	ADP
admet-661	21	15	aqueous	aqueous	ADJ
admet-661	21	16	media	medium	NOUN
admet-661	21	17	.	.	PUNCT
admet-661	22	1	according	accord	VERB
admet-661	22	2	to	to	ADP
admet-661	22	3	kale	kale	PROPN
admet-661	22	4	et	et	PROPN
admet-661	22	5	al	al	PROPN
admet-661	22	6	.	.	PUNCT
admet-661	23	1	[	[	X
admet-661	23	2	9	9	NUM
admet-661	23	3	]	]	PUNCT
admet-661	23	4	,	,	PUNCT
admet-661	23	5	the	the	DET
admet-661	23	6	development	development	NOUN
admet-661	23	7	of	of	ADP
admet-661	23	8	cocrystals	cocrystal	NOUN
admet-661	23	9	into	into	ADP
admet-661	23	10	viable	viable	ADJ
admet-661	23	11	drug	drug	NOUN
admet-661	23	12	products	product	NOUN
admet-661	23	13	could	could	AUX
admet-661	23	14	be	be	AUX
admet-661	23	15	challenging	challenge	VERB
admet-661	23	16	because	because	SCONJ
admet-661	23	17	of	of	ADP
admet-661	23	18	such	such	ADJ
admet-661	23	19	factors	factor	NOUN
admet-661	23	20	as	as	ADP
admet-661	23	21	‘	'	PUNCT
admet-661	23	22	lower	low	ADJ
admet-661	23	23	than	than	SCONJ
admet-661	23	24	expected	expect	VERB
admet-661	23	25	supersaturation	supersaturation	NOUN
admet-661	23	26	solubility	solubility	NOUN
admet-661	23	27	,	,	PUNCT
admet-661	23	28	safety	safety	NOUN
admet-661	23	29	of	of	ADP
admet-661	23	30	coformer	coformer	NOUN
admet-661	23	31	,	,	PUNCT
admet-661	23	32	difficulties	difficulty	NOUN
admet-661	23	33	in	in	ADP
admet-661	23	34	the	the	DET
admet-661	23	35	manufacturing	manufacturing	NOUN
admet-661	23	36	of	of	ADP
admet-661	23	37	high	high	ADJ
admet-661	23	38	-	-	PUNCT
admet-661	23	39	dose	dose	NOUN
admet-661	23	40	drugs	drug	NOUN
admet-661	23	41	,	,	PUNCT
admet-661	23	42	polymorphism	polymorphism	NOUN
admet-661	23	43	,	,	PUNCT
admet-661	23	44	atypical	atypical	ADJ
admet-661	23	45	behavior	behavior	NOUN
admet-661	23	46	of	of	ADP
admet-661	23	47	cocrystal	cocrystal	NOUN
admet-661	23	48	in	in	ADP
admet-661	23	49	the	the	DET
admet-661	23	50	formulation	formulation	NOUN
admet-661	23	51	,	,	PUNCT
admet-661	23	52	difficulty	difficulty	NOUN
admet-661	23	53	in	in	ADP
admet-661	23	54	ivivc	ivivc	NOUN
admet-661	23	55	,	,	PUNCT
admet-661	23	56	and	and	CCONJ
admet-661	23	57	so	so	ADV
admet-661	23	58	forth	forth	ADV
admet-661	23	59	.	.	PUNCT
admet-661	24	1	despite	despite	SCONJ
admet-661	24	2	such	such	ADJ
admet-661	24	3	challenges	challenge	NOUN
admet-661	24	4	,	,	PUNCT
admet-661	24	5	there	there	PRON
admet-661	24	6	is	be	VERB
admet-661	24	7	active	active	ADJ
admet-661	24	8	research	research	NOUN
admet-661	24	9	on	on	ADP
admet-661	24	10	the	the	DET
admet-661	24	11	development	development	NOUN
admet-661	24	12	of	of	ADP
admet-661	24	13	cocrystals	cocrystal	NOUN
admet-661	24	14	as	as	ADP
admet-661	24	15	potential	potential	ADJ
admet-661	24	16	drug	drug	NOUN
admet-661	24	17	products	product	NOUN
admet-661	24	18	,	,	PUNCT
admet-661	24	19	and	and	CCONJ
admet-661	24	20	to	to	ADP
admet-661	24	21	the	the	DET
admet-661	24	22	best	good	ADJ
admet-661	24	23	of	of	ADP
admet-661	24	24	our	our	PRON
admet-661	24	25	knowledge	knowledge	NOUN
admet-661	24	26	,	,	PUNCT
admet-661	24	27	three	three	NUM
admet-661	24	28	of	of	ADP
admet-661	24	29	them	they	PRON
admet-661	24	30	have	have	AUX
admet-661	24	31	already	already	ADV
admet-661	24	32	received	receive	VERB
admet-661	24	33	regulatory	regulatory	ADJ
admet-661	24	34	approvals	approval	NOUN
admet-661	24	35	.	.	PUNCT
admet-661	25	1	the	the	DET
admet-661	25	2	first	first	ADJ
admet-661	25	3	is	be	AUX
admet-661	25	4	ipragliflozin	ipragliflozin	NOUN
admet-661	25	5	l	l	NOUN
admet-661	25	6	-	-	NOUN
admet-661	25	7	proline	proline	NOUN
admet-661	25	8	,	,	PUNCT
admet-661	25	9	a	a	DET
admet-661	25	10	1:1	1:1	NUM
admet-661	25	11	cocrystal	cocrystal	NOUN
admet-661	25	12	of	of	ADP
admet-661	25	13	the	the	DET
admet-661	25	14	selective	selective	ADJ
admet-661	25	15	sglt2	sglt2	ADJ
admet-661	25	16	inhibitor	inhibitor	NOUN
admet-661	25	17	ipragliflozin	ipragliflozin	VERB
admet-661	25	18	with	with	ADP
admet-661	25	19	l	l	NOUN
admet-661	25	20	-	-	NOUN
admet-661	25	21	proline	proline	NOUN
admet-661	25	22	,	,	PUNCT
admet-661	25	23	which	which	PRON
admet-661	25	24	received	receive	VERB
admet-661	25	25	approval	approval	NOUN
admet-661	25	26	in	in	ADP
admet-661	25	27	japan	japan	PROPN
admet-661	25	28	in	in	ADP
admet-661	25	29	2014	2014	NUM
admet-661	25	30	for	for	ADP
admet-661	25	31	the	the	DET
admet-661	25	32	treatment	treatment	NOUN
admet-661	25	33	of	of	ADP
admet-661	25	34	type	type	NOUN
admet-661	25	35	2	2	NUM
admet-661	25	36	diabetes	diabetes	NOUN
admet-661	25	37	(	(	PUNCT
admet-661	25	38	suglat	suglat	ADJ
admet-661	25	39	®	®	NOUN
admet-661	25	40	tablet	tablet	NOUN
admet-661	25	41	;	;	PUNCT
admet-661	25	42	astellas	astella	NOUN
admet-661	25	43	)	)	PUNCT
admet-661	26	1	[	[	X
admet-661	26	2	10,11	10,11	NOUN
admet-661	26	3	]	]	X
admet-661	26	4	;	;	PUNCT
admet-661	26	5	to	to	ADP
admet-661	26	6	the	the	DET
admet-661	26	7	best	good	ADJ
admet-661	26	8	of	of	ADP
admet-661	26	9	our	our	PRON
admet-661	26	10	knowledge	knowledge	NOUN
admet-661	26	11	,	,	PUNCT
admet-661	26	12	it	it	PRON
admet-661	26	13	is	be	AUX
admet-661	26	14	not	not	PART
admet-661	26	15	yet	yet	ADV
admet-661	26	16	available	available	ADJ
admet-661	26	17	in	in	ADP
admet-661	26	18	the	the	DET
admet-661	26	19	usa	usa	PROPN
admet-661	26	20	or	or	CCONJ
admet-661	26	21	european	european	ADJ
admet-661	26	22	countries	country	NOUN
admet-661	26	23	.	.	PUNCT
admet-661	27	1	the	the	DET
admet-661	27	2	second	second	NOUN
admet-661	27	3	is	be	AUX
admet-661	27	4	sacubitril	sacubitril	ADV
admet-661	27	5	/	/	SYM
admet-661	27	6	valsartan	valsartan	PROPN
admet-661	27	7	,	,	PUNCT
admet-661	27	8	which	which	PRON
admet-661	27	9	is	be	AUX
admet-661	27	10	a	a	DET
admet-661	27	11	1:1	1:1	NUM
admet-661	27	12	cocrystal	cocrystal	NOUN
admet-661	27	13	between	between	ADP
admet-661	27	14	sacubitril	sacubitril	ADJ
admet-661	27	15	sodium	sodium	NOUN
admet-661	27	16	,	,	PUNCT
admet-661	27	17	a	a	DET
admet-661	27	18	neprilysin	neprilysin	NOUN
admet-661	27	19	(	(	PUNCT
admet-661	27	20	nep	nep	NOUN
admet-661	27	21	)	)	PUNCT
admet-661	27	22	inhibitor	inhibitor	NOUN
admet-661	27	23	,	,	PUNCT
admet-661	27	24	and	and	CCONJ
admet-661	27	25	valsartan	valsartan	PROPN
admet-661	27	26	sodium	sodium	PROPN
admet-661	27	27	,	,	PUNCT
admet-661	27	28	an	an	DET
admet-661	27	29	angiotensin	angiotensin	NOUN
admet-661	27	30	receptor	receptor	NOUN
admet-661	27	31	1	1	NUM
admet-661	27	32	(	(	PUNCT
admet-661	27	33	at1	at1	PROPN
admet-661	27	34	)	)	PUNCT
admet-661	27	35	blocker	blocker	NOUN
admet-661	27	36	(	(	PUNCT
admet-661	27	37	entresto	entresto	PROPN
admet-661	27	38	®	®	NOUN
admet-661	27	39	tablet	tablet	NOUN
admet-661	27	40	;	;	PUNCT
admet-661	27	41	novartis	novartis	PROPN
admet-661	27	42	)	)	PUNCT
admet-661	27	43	;	;	PUNCT
admet-661	27	44	it	it	PRON
admet-661	27	45	was	be	AUX
admet-661	27	46	approved	approve	VERB
admet-661	27	47	by	by	ADP
admet-661	27	48	the	the	DET
admet-661	27	49	fda	fda	PROPN
admet-661	27	50	and	and	CCONJ
admet-661	27	51	the	the	DET
admet-661	27	52	european	european	PROPN
admet-661	27	53	medicines	medicines	PROPN
admet-661	27	54	agency	agency	NOUN
admet-661	27	55	(	(	PUNCT
admet-661	27	56	ema	ema	PROPN
admet-661	27	57	)	)	PUNCT
admet-661	27	58	in	in	ADP
admet-661	27	59	2015	2015	NUM
admet-661	27	60	for	for	ADP
admet-661	27	61	the	the	DET
admet-661	27	62	treatment	treatment	NOUN
admet-661	27	63	of	of	ADP
admet-661	27	64	long	long	ADJ
admet-661	27	65	-	-	PUNCT
admet-661	27	66	term	term	NOUN
admet-661	27	67	heart	heart	NOUN
admet-661	27	68	failure	failure	NOUN
admet-661	27	69	in	in	ADP
admet-661	27	70	adult	adult	NOUN
admet-661	27	71	population	population	NOUN
admet-661	27	72	.	.	PUNCT
admet-661	28	1	the	the	DET
admet-661	28	2	third	third	ADJ
admet-661	28	3	is	be	AUX
admet-661	28	4	etrugliflozin	etrugliflozin	PROPN
admet-661	28	5	l	l	PROPN
admet-661	28	6	-	-	NOUN
admet-661	28	7	pga	pga	NOUN
admet-661	28	8	,	,	PUNCT
admet-661	28	9	which	which	PRON
admet-661	28	10	is	be	AUX
admet-661	28	11	a	a	DET
admet-661	28	12	1:1	1:1	NUM
admet-661	28	13	cocrystal	cocrystal	NOUN
admet-661	28	14	between	between	ADP
admet-661	28	15	etrugliflozin	etrugliflozin	PROPN
admet-661	28	16	,	,	PUNCT
admet-661	28	17	another	another	DET
admet-661	28	18	sglt2	sglt2	ADJ
admet-661	28	19	inhibitor	inhibitor	NOUN
admet-661	28	20	,	,	PUNCT
admet-661	28	21	and	and	CCONJ
admet-661	28	22	l	l	ADJ
admet-661	28	23	-	-	ADJ
admet-661	28	24	pyroglutamic	pyroglutamic	ADJ
admet-661	28	25	acid	acid	NOUN
admet-661	28	26	;	;	PUNCT
admet-661	28	27	it	it	PRON
admet-661	28	28	received	receive	VERB
admet-661	28	29	fda	fda	PROPN
admet-661	28	30	and	and	CCONJ
admet-661	28	31	ema	ema	PROPN
admet-661	28	32	approvals	approval	NOUN
admet-661	28	33	in	in	ADP
admet-661	28	34	,	,	PUNCT
admet-661	28	35	respectively	respectively	ADV
admet-661	28	36	,	,	PUNCT
admet-661	28	37	2017	2017	NUM
admet-661	28	38	and	and	CCONJ
admet-661	28	39	2018	2018	NUM
admet-661	28	40	for	for	ADP
admet-661	28	41	the	the	DET
admet-661	28	42	treatment	treatment	NOUN
admet-661	28	43	of	of	ADP
admet-661	28	44	type	type	NOUN
admet-661	28	45	ii	ii	NOUN
admet-661	28	46	diabetes	diabetes	NOUN
admet-661	28	47	(	(	PUNCT
admet-661	28	48	steglatro	steglatro	VERB
admet-661	28	49	®	®	NOUN
admet-661	28	50	tablets	tablet	NOUN
admet-661	28	51	;	;	PUNCT
admet-661	28	52	merck	merck	NOUN
admet-661	28	53	/	/	SYM
admet-661	28	54	pfizer	pfizer	NOUN
admet-661	28	55	)	)	PUNCT
admet-661	28	56	.	.	PUNCT
admet-661	29	1	there	there	PRON
admet-661	29	2	is	be	VERB
admet-661	29	3	not	not	PART
admet-661	29	4	much	much	ADJ
admet-661	29	5	information	information	NOUN
admet-661	29	6	in	in	ADP
admet-661	29	7	the	the	DET
admet-661	29	8	published	publish	VERB
admet-661	29	9	literature	literature	NOUN
admet-661	29	10	on	on	ADP
admet-661	29	11	physicochemical	physicochemical	ADJ
admet-661	29	12	properties	property	NOUN
admet-661	29	13	of	of	ADP
admet-661	29	14	these	these	DET
admet-661	29	15	cocrystals	cocrystal	NOUN
admet-661	29	16	and	and	CCONJ
admet-661	29	17	what	what	DET
admet-661	29	18	advantages	advantage	NOUN
admet-661	29	19	they	they	PRON
admet-661	29	20	provide	provide	VERB
admet-661	29	21	over	over	ADP
admet-661	29	22	those	those	PRON
admet-661	29	23	of	of	ADP
admet-661	29	24	their	their	PRON
admet-661	29	25	parent	parent	NOUN
admet-661	29	26	molecules	molecule	NOUN
admet-661	29	27	.	.	PUNCT
admet-661	30	1	there	there	PRON
admet-661	30	2	is	be	VERB
admet-661	30	3	the	the	DET
admet-661	30	4	potential	potential	NOUN
admet-661	30	5	that	that	SCONJ
admet-661	30	6	a	a	DET
admet-661	30	7	cocrystal	cocrystal	NOUN
admet-661	30	8	may	may	AUX
admet-661	30	9	have	have	AUX
admet-661	30	10	higher	high	ADJ
admet-661	30	11	solubility	solubility	NOUN
admet-661	30	12	than	than	ADP
admet-661	30	13	that	that	PRON
admet-661	30	14	of	of	ADP
admet-661	30	15	the	the	DET
admet-661	30	16	parent	parent	NOUN
admet-661	30	17	chemical	chemical	NOUN
admet-661	30	18	entity	entity	NOUN
admet-661	30	19	.	.	PUNCT
admet-661	31	1	however	however	ADV
admet-661	31	2	,	,	PUNCT
admet-661	31	3	the	the	DET
admet-661	31	4	solubility	solubility	NOUN
admet-661	31	5	improvement	improvement	NOUN
admet-661	31	6	was	be	AUX
admet-661	31	7	possibly	possibly	ADV
admet-661	31	8	not	not	PART
admet-661	31	9	the	the	DET
admet-661	31	10	primary	primary	ADJ
admet-661	31	11	reasons	reason	NOUN
admet-661	31	12	why	why	SCONJ
admet-661	31	13	the	the	DET
admet-661	31	14	three	three	NUM
admet-661	31	15	marketed	market	VERB
admet-661	31	16	cocrystals	cocrystal	NOUN
admet-661	31	17	were	be	AUX
admet-661	31	18	developed	develop	VERB
admet-661	31	19	.	.	PUNCT
admet-661	32	1	in	in	ADP
admet-661	32	2	case	case	NOUN
admet-661	32	3	of	of	ADP
admet-661	32	4	ipragliflozin	ipragliflozin	PROPN
admet-661	32	5	l	l	NOUN
admet-661	32	6	-	-	NOUN
admet-661	32	7	proline	proline	NOUN
admet-661	32	8	(	(	PUNCT
admet-661	32	9	suglat	suglat	ADJ
admet-661	32	10	®	®	PROPN
admet-661	32	11	)	)	PUNCT
admet-661	32	12	,	,	PUNCT
admet-661	32	13	the	the	DET
admet-661	32	14	chemical	chemical	ADJ
admet-661	32	15	structure	structure	NOUN
admet-661	32	16	of	of	ADP
admet-661	32	17	ipragliflozin	ipragliflozin	PROPN
admet-661	32	18	indicates	indicate	VERB
admet-661	32	19	that	that	SCONJ
admet-661	32	20	,	,	PUNCT
admet-661	32	21	by	by	ADP
admet-661	32	22	itself	itself	PRON
admet-661	32	23	,	,	PUNCT
admet-661	32	24	it	it	PRON
admet-661	32	25	could	could	AUX
admet-661	32	26	be	be	AUX
admet-661	32	27	water	water	NOUN
admet-661	32	28	-	-	PUNCT
admet-661	32	29	soluble	soluble	ADJ
admet-661	32	30	since	since	SCONJ
admet-661	32	31	it	it	PRON
admet-661	32	32	is	be	AUX
admet-661	32	33	a	a	DET
admet-661	32	34	glycoside	glycoside	NOUN
admet-661	32	35	with	with	ADP
admet-661	32	36	a	a	DET
admet-661	32	37	-f	-f	NUM
admet-661	32	38	and	and	CCONJ
admet-661	32	39	several	several	ADJ
admet-661	32	40	–	–	PUNCT
admet-661	32	41	oh	oh	NUM
admet-661	32	42	groups	group	NOUN
admet-661	33	1	[	[	X
admet-661	33	2	10	10	NUM
admet-661	33	3	]	]	PUNCT
admet-661	33	4	,	,	PUNCT
admet-661	33	5	and	and	CCONJ
admet-661	33	6	,	,	PUNCT
admet-661	33	7	therefore	therefore	ADV
admet-661	33	8	,	,	PUNCT
admet-661	33	9	the	the	DET
admet-661	33	10	cocrystal	cocrystal	NOUN
admet-661	33	11	was	be	AUX
admet-661	33	12	possibly	possibly	ADV
admet-661	33	13	developed	develop	VERB
admet-661	33	14	for	for	ADP
admet-661	33	15	certain	certain	ADJ
admet-661	33	16	other	other	ADJ
admet-661	33	17	advantages	advantage	NOUN
admet-661	33	18	than	than	ADP
admet-661	33	19	the	the	DET
admet-661	33	20	solubility	solubility	NOUN
admet-661	33	21	improvement	improvement	NOUN
admet-661	33	22	.	.	PUNCT
admet-661	34	1	in	in	ADP
admet-661	34	2	case	case	NOUN
admet-661	34	3	of	of	ADP
admet-661	34	4	sacubitril	sacubitril	ADJ
admet-661	34	5	/	/	SYM
admet-661	34	6	valsartan	valsartan	PROPN
admet-661	34	7	(	(	PUNCT
admet-661	34	8	entresto	entresto	PROPN
admet-661	34	9	®	®	PROPN
admet-661	34	10	)	)	PUNCT
admet-661	34	11	,	,	PUNCT
admet-661	34	12	both	both	DET
admet-661	34	13	components	component	NOUN
admet-661	34	14	were	be	AUX
admet-661	34	15	active	active	ADJ
admet-661	34	16	moieties	moiety	NOUN
admet-661	34	17	,	,	PUNCT
admet-661	34	18	and	and	CCONJ
admet-661	34	19	it	it	PRON
admet-661	34	20	was	be	AUX
admet-661	34	21	not	not	PART
admet-661	34	22	a	a	DET
admet-661	34	23	typical	typical	ADJ
admet-661	34	24	cocrystal	cocrystal	NOUN
admet-661	34	25	between	between	ADP
admet-661	34	26	drug	drug	NOUN
admet-661	34	27	and	and	CCONJ
admet-661	34	28	therapeutically	therapeutically	ADV
admet-661	34	29	inactive	inactive	ADJ
admet-661	34	30	coformer	coformer	NOUN
admet-661	34	31	.	.	PUNCT
admet-661	35	1	also	also	ADV
admet-661	35	2	,	,	PUNCT
admet-661	35	3	since	since	SCONJ
admet-661	35	4	both	both	DET
admet-661	35	5	components	component	NOUN
admet-661	35	6	of	of	ADP
admet-661	35	7	the	the	DET
admet-661	35	8	cocrystal	cocrystal	NOUN
admet-661	35	9	were	be	AUX
admet-661	35	10	water	water	NOUN
admet-661	35	11	-	-	PUNCT
admet-661	35	12	soluble	soluble	ADJ
admet-661	35	13	sodium	sodium	NOUN
admet-661	35	14	salts	salt	NOUN
admet-661	35	15	,	,	PUNCT
admet-661	35	16	the	the	DET
admet-661	35	17	primary	primary	ADJ
admet-661	35	18	advantage	advantage	NOUN
admet-661	35	19	of	of	ADP
admet-661	35	20	cocrystal	cocrystal	ADJ
admet-661	35	21	formation	formation	NOUN
admet-661	35	22	in	in	ADP
admet-661	35	23	this	this	DET
admet-661	35	24	case	case	NOUN
admet-661	35	25	appears	appear	VERB
admet-661	35	26	to	to	PART
admet-661	35	27	be	be	AUX
admet-661	35	28	the	the	DET
admet-661	35	29	improvement	improvement	NOUN
admet-661	35	30	of	of	ADP
admet-661	35	31	physicochemical	physicochemical	ADJ
admet-661	35	32	properties	property	NOUN
admet-661	35	33	of	of	ADP
admet-661	35	34	materials	material	NOUN
admet-661	35	35	by	by	ADP
admet-661	35	36	crystallizing	crystallize	VERB
admet-661	35	37	two	two	NUM
admet-661	35	38	otherwise	otherwise	ADV
admet-661	35	39	amorphous	amorphous	ADJ
admet-661	35	40	or	or	CCONJ
admet-661	35	41	less	less	ADV
admet-661	35	42	crystalline	crystalline	ADJ
admet-661	35	43	api	api	NOUN
admet-661	35	44	together	together	ADV
admet-661	35	45	as	as	ADP
admet-661	35	46	one	one	NUM
admet-661	35	47	highly	highly	ADV
admet-661	35	48	crystalline	crystalline	ADJ
admet-661	35	49	drug	drug	NOUN
admet-661	35	50	substance	substance	NOUN
admet-661	35	51	[	[	X
admet-661	35	52	12	12	NUM
admet-661	35	53	]	]	PUNCT
admet-661	35	54	.	.	PUNCT
admet-661	36	1	etrugliflozin	etrugliflozin	PROPN
admet-661	36	2	is	be	AUX
admet-661	36	3	a	a	DET
admet-661	36	4	biopharmaceutics	biopharmaceutics	NOUN
admet-661	36	5	classification	classification	NOUN
admet-661	36	6	i	i	PRON
admet-661	36	7	(	(	PUNCT
admet-661	36	8	bcs	bcs	NOUN
admet-661	36	9	i	i	PROPN
admet-661	36	10	)	)	PUNCT
admet-661	36	11	drug	drug	NOUN
admet-661	36	12	having	have	VERB
admet-661	36	13	good	good	ADJ
admet-661	36	14	solubility	solubility	NOUN
admet-661	36	15	and	and	CCONJ
admet-661	36	16	good	good	ADJ
admet-661	36	17	permeability	permeability	NOUN
admet-661	36	18	throughout	throughout	ADP
admet-661	36	19	the	the	DET
admet-661	36	20	gastrointestinal	gastrointestinal	ADJ
admet-661	36	21	ph	ph	ADJ
admet-661	36	22	range	range	NOUN
admet-661	36	23	[	[	X
admet-661	36	24	13	13	NUM
admet-661	36	25	]	]	PUNCT
admet-661	36	26	and	and	CCONJ
admet-661	36	27	,	,	PUNCT
admet-661	36	28	therefore	therefore	ADV
admet-661	36	29	,	,	PUNCT
admet-661	36	30	its	its	PRON
admet-661	36	31	conversion	conversion	NOUN
admet-661	36	32	to	to	ADP
admet-661	36	33	etrugliflozin	etrugliflozin	PROPN
admet-661	36	34	l	l	PROPN
admet-661	36	35	-	-	PROPN
admet-661	36	36	pga	pga	NOUN
admet-661	36	37	cocrystal	cocrystal	NOUN
admet-661	36	38	(	(	PUNCT
admet-661	36	39	steglatro	steglatro	PROPN
admet-661	36	40	®	®	NOUN
admet-661	36	41	)	)	PUNCT
admet-661	36	42	could	could	AUX
admet-661	36	43	also	also	ADV
admet-661	36	44	be	be	AUX
admet-661	36	45	for	for	ADP
admet-661	36	46	reasons	reason	NOUN
admet-661	36	47	other	other	ADJ
admet-661	36	48	than	than	ADP
admet-661	36	49	the	the	DET
admet-661	36	50	solubility	solubility	NOUN
admet-661	36	51	enhancement	enhancement	NOUN
admet-661	36	52	.	.	PUNCT
admet-661	37	1	although	although	SCONJ
admet-661	37	2	,	,	PUNCT
admet-661	37	3	as	as	SCONJ
admet-661	37	4	mentioned	mention	VERB
admet-661	37	5	above	above	ADV
admet-661	37	6	,	,	PUNCT
admet-661	37	7	there	there	PRON
admet-661	37	8	may	may	AUX
admet-661	37	9	be	be	AUX
admet-661	37	10	different	different	ADJ
admet-661	37	11	reasons	reason	NOUN
admet-661	37	12	behind	behind	ADP
admet-661	37	13	the	the	DET
admet-661	37	14	development	development	NOUN
admet-661	37	15	of	of	ADP
admet-661	37	16	cocrystals	cocrystal	NOUN
admet-661	37	17	,	,	PUNCT
admet-661	37	18	much	much	ADJ
admet-661	37	19	of	of	ADP
admet-661	37	20	the	the	DET
admet-661	37	21	recent	recent	ADJ
admet-661	37	22	interest	interest	NOUN
admet-661	37	23	in	in	ADP
admet-661	37	24	this	this	DET
admet-661	37	25	area	area	NOUN
admet-661	37	26	appears	appear	VERB
admet-661	37	27	to	to	PART
admet-661	37	28	be	be	AUX
admet-661	37	29	the	the	DET
admet-661	37	30	potential	potential	ADJ
admet-661	37	31	advantage	advantage	NOUN
admet-661	37	32	of	of	ADP
admet-661	37	33	using	use	VERB
admet-661	37	34	cocrystals	cocrystal	NOUN
admet-661	37	35	to	to	PART
admet-661	37	36	improve	improve	VERB
admet-661	37	37	solubility	solubility	NOUN
admet-661	37	38	and	and	CCONJ
admet-661	37	39	dissolution	dissolution	NOUN
admet-661	37	40	rate	rate	NOUN
admet-661	37	41	of	of	ADP
admet-661	37	42	poorly	poorly	ADV
admet-661	37	43	water	water	NOUN
admet-661	37	44	-	-	PUNCT
admet-661	37	45	soluble	soluble	ADJ
admet-661	37	46	drugs	drug	NOUN
admet-661	37	47	[	[	X
admet-661	37	48	14,15	14,15	NUM
admet-661	37	49	]	]	PUNCT
admet-661	37	50	.	.	PUNCT
admet-661	38	1	however	however	ADV
admet-661	38	2	,	,	PUNCT
admet-661	38	3	there	there	PRON
admet-661	38	4	are	be	VERB
admet-661	38	5	mixed	mixed	ADJ
admet-661	38	6	reports	report	NOUN
admet-661	38	7	in	in	ADP
admet-661	38	8	the	the	DET
admet-661	38	9	literature	literature	NOUN
admet-661	38	10	on	on	ADP
admet-661	38	11	the	the	DET
admet-661	38	12	actual	actual	ADJ
admet-661	38	13	increase	increase	NOUN
admet-661	38	14	in	in	ADP
admet-661	38	15	aqueous	aqueous	ADJ
admet-661	38	16	solubility	solubility	NOUN
admet-661	38	17	that	that	PRON
admet-661	38	18	may	may	AUX
admet-661	38	19	be	be	AUX
admet-661	38	20	attained	attain	VERB
admet-661	38	21	by	by	ADP
admet-661	38	22	cocrystal	cocrystal	ADJ
admet-661	38	23	formation	formation	NOUN
admet-661	38	24	.	.	PUNCT
admet-661	39	1	kozak	kozak	PROPN
admet-661	39	2	et	et	PROPN
admet-661	39	3	al	al	PROPN
admet-661	39	4	.	.	PUNCT
admet-661	40	1	[	[	X
admet-661	40	2	16	16	NUM
admet-661	40	3	]	]	PUNCT
admet-661	40	4	reported	report	VERB
admet-661	40	5	that	that	SCONJ
admet-661	40	6	the	the	DET
admet-661	40	7	solubility	solubility	NOUN
admet-661	40	8	of	of	ADP
admet-661	40	9	a	a	DET
admet-661	40	10	neutral	neutral	ADJ
admet-661	40	11	compound	compound	NOUN
admet-661	40	12	ethenzamide	ethenzamide	NOUN
admet-661	40	13	in	in	ADP
admet-661	40	14	water	water	NOUN
admet-661	40	15	increased	increase	VERB
admet-661	40	16	from	from	ADP
admet-661	40	17	around	around	ADV
admet-661	40	18	0.80	0.80	NUM
admet-661	40	19	-	-	SYM
admet-661	40	20	0.85	0.85	NUM
admet-661	40	21	µg	µg	NOUN
admet-661	40	22	/	/	SYM
admet-661	40	23	ml	ml	NOUN
admet-661	40	24	to	to	ADP
admet-661	40	25	around	around	ADV
admet-661	40	26	1.20	1.20	NUM
admet-661	40	27	-	-	SYM
admet-661	40	28	1.30	1.30	NUM
admet-661	40	29	µg	µg	NOUN
admet-661	40	30	/	/	SYM
admet-661	40	31	ml	ml	VERB
admet-661	40	32	by	by	ADP
admet-661	40	33	cocrystallization	cocrystallization	NOUN
admet-661	40	34	with	with	ADP
admet-661	40	35	glutaric	glutaric	ADJ
admet-661	40	36	acid	acid	NOUN
admet-661	40	37	,	,	PUNCT
admet-661	40	38	malonic	malonic	ADJ
admet-661	40	39	acid	acid	NOUN
admet-661	40	40	and	and	CCONJ
admet-661	40	41	maleic	maleic	VERB
admet-661	40	42	acid	acid	NOUN
admet-661	40	43	.	.	PUNCT
admet-661	41	1	although	although	SCONJ
admet-661	41	2	this	this	PRON
admet-661	41	3	could	could	AUX
admet-661	41	4	be	be	AUX
admet-661	41	5	1.4	1.4	NUM
admet-661	41	6	-	-	SYM
admet-661	41	7	1.6	1.6	NUM
admet-661	41	8	time	time	NOUN
admet-661	41	9	increase	increase	NOUN
admet-661	41	10	in	in	ADP
admet-661	41	11	solubility	solubility	NOUN
admet-661	41	12	,	,	PUNCT
admet-661	41	13	considering	consider	VERB
admet-661	41	14	the	the	DET
admet-661	41	15	vasoya	vasoya	PROPN
admet-661	41	16	et	et	PROPN
admet-661	41	17	al	al	PROPN
admet-661	41	18	.	.	PROPN
admet-661	41	19	admet	admet	PROPN
admet-661	41	20	&	&	CCONJ
admet-661	41	21	dmpk	dmpk	PROPN
admet-661	41	22	7(2	7(2	NUM
admet-661	41	23	)	)	PUNCT
admet-661	41	24	(	(	PUNCT
admet-661	41	25	2019	2019	NUM
admet-661	41	26	)	)	PUNCT
admet-661	41	27	106	106	NUM
admet-661	41	28	-	-	SYM
admet-661	41	29	130	130	NUM
admet-661	41	30	108	108	NUM
admet-661	41	31	extremely	extremely	ADV
admet-661	41	32	low	low	ADJ
admet-661	41	33	aqueous	aqueous	ADJ
admet-661	41	34	solubility	solubility	NOUN
admet-661	41	35	of	of	ADP
admet-661	41	36	ethenzamide	ethenzamide	NOUN
admet-661	41	37	and	and	CCONJ
admet-661	41	38	the	the	DET
admet-661	41	39	cocrystals	cocrystal	NOUN
admet-661	41	40	,	,	PUNCT
admet-661	41	41	the	the	DET
admet-661	41	42	increase	increase	NOUN
admet-661	41	43	may	may	AUX
admet-661	41	44	not	not	PART
admet-661	41	45	be	be	AUX
admet-661	41	46	of	of	ADP
admet-661	41	47	biopharmaceutical	biopharmaceutical	ADJ
admet-661	41	48	significance	significance	NOUN
admet-661	41	49	.	.	PUNCT
admet-661	42	1	indeed	indeed	ADV
admet-661	42	2	,	,	PUNCT
admet-661	42	3	the	the	DET
admet-661	42	4	cocrystallization	cocrystallization	NOUN
admet-661	42	5	did	do	AUX
admet-661	42	6	not	not	PART
admet-661	42	7	increase	increase	VERB
admet-661	42	8	dissolution	dissolution	ADJ
admet-661	42	9	rates	rate	NOUN
admet-661	42	10	of	of	ADP
admet-661	42	11	ethenzamide	ethenzamide	NOUN
admet-661	42	12	,	,	PUNCT
admet-661	42	13	and	and	CCONJ
admet-661	42	14	,	,	PUNCT
admet-661	42	15	rather	rather	ADV
admet-661	42	16	,	,	PUNCT
admet-661	42	17	cocrystals	cocrystal	NOUN
admet-661	42	18	exhibited	exhibit	VERB
admet-661	42	19	lower	low	ADJ
admet-661	42	20	dissolution	dissolution	NOUN
admet-661	42	21	rates	rate	NOUN
admet-661	42	22	in	in	ADP
admet-661	42	23	water	water	NOUN
admet-661	42	24	than	than	ADP
admet-661	42	25	the	the	DET
admet-661	42	26	parent	parent	NOUN
admet-661	42	27	compound	compound	NOUN
admet-661	42	28	.	.	PUNCT
admet-661	43	1	although	although	SCONJ
admet-661	43	2	possibly	possibly	ADV
admet-661	43	3	not	not	PART
admet-661	43	4	suitable	suitable	ADJ
admet-661	43	5	for	for	ADP
admet-661	43	6	neutral	neutral	ADJ
admet-661	43	7	compounds	compound	NOUN
admet-661	43	8	,	,	PUNCT
admet-661	43	9	it	it	PRON
admet-661	43	10	could	could	AUX
admet-661	43	11	be	be	AUX
admet-661	43	12	possible	possible	ADJ
admet-661	43	13	that	that	SCONJ
admet-661	43	14	the	the	DET
admet-661	43	15	cocrystal	cocrystal	ADJ
admet-661	43	16	formation	formation	NOUN
admet-661	43	17	may	may	AUX
admet-661	43	18	be	be	AUX
admet-661	43	19	especially	especially	ADV
admet-661	43	20	advantageous	advantageous	ADJ
admet-661	43	21	to	to	ADP
admet-661	43	22	basic	basic	ADJ
admet-661	43	23	and	and	CCONJ
admet-661	43	24	acidic	acidic	ADJ
admet-661	43	25	compounds	compound	NOUN
admet-661	43	26	in	in	ADP
admet-661	43	27	cases	case	NOUN
admet-661	43	28	where	where	SCONJ
admet-661	43	29	they	they	PRON
admet-661	43	30	do	do	AUX
admet-661	43	31	not	not	PART
admet-661	43	32	normally	normally	ADV
admet-661	43	33	form	form	VERB
admet-661	43	34	salts	salt	NOUN
admet-661	43	35	.	.	PUNCT
admet-661	44	1	stanton	stanton	PROPN
admet-661	44	2	and	and	CCONJ
admet-661	44	3	bak	bak	VERB
admet-661	44	4	[	[	X
admet-661	44	5	17	17	NUM
admet-661	44	6	]	]	PUNCT
admet-661	44	7	determined	determine	VERB
admet-661	44	8	comparative	comparative	ADJ
admet-661	44	9	solubility	solubility	NOUN
admet-661	44	10	of	of	ADP
admet-661	44	11	ten	ten	NUM
admet-661	44	12	cocrystals	cocrystal	NOUN
admet-661	44	13	of	of	ADP
admet-661	44	14	an	an	DET
admet-661	44	15	experimental	experimental	ADJ
admet-661	44	16	basic	basic	ADJ
admet-661	44	17	drug	drug	NOUN
admet-661	44	18	,	,	PUNCT
admet-661	44	19	amg	amg	PROPN
admet-661	44	20	517	517	NUM
admet-661	44	21	(	(	PUNCT
admet-661	44	22	pka	pka	PROPN
admet-661	44	23	0.68	0.68	NUM
admet-661	44	24	)	)	PUNCT
admet-661	44	25	,	,	PUNCT
admet-661	44	26	with	with	ADP
admet-661	44	27	ten	ten	NUM
admet-661	44	28	acids	acid	NOUN
admet-661	44	29	(	(	PUNCT
admet-661	44	30	pka	pka	PROPN
admet-661	44	31	3.07	3.07	NUM
admet-661	44	32	to	to	ADP
admet-661	44	33	4.20	4.20	NUM
admet-661	44	34	)	)	PUNCT
admet-661	44	35	in	in	ADP
admet-661	44	36	simulated	simulate	VERB
admet-661	44	37	fasted	fast	VERB
admet-661	44	38	intestinal	intestinal	ADJ
admet-661	44	39	fluid	fluid	NOUN
admet-661	44	40	(	(	PUNCT
admet-661	44	41	fasif	fasif	NOUN
admet-661	44	42	;	;	PUNCT
admet-661	44	43	5	5	NUM
admet-661	44	44	mm	mm	NUM
admet-661	44	45	sodium	sodium	NOUN
admet-661	44	46	taurocholate	taurocholate	NOUN
admet-661	44	47	and	and	CCONJ
admet-661	44	48	1.5	1.5	NUM
admet-661	44	49	mm	mm	NOUN
admet-661	44	50	lecithin	lecithin	NOUN
admet-661	44	51	in	in	ADP
admet-661	44	52	ph	ph	ADJ
admet-661	44	53	6.8	6.8	NUM
admet-661	44	54	phosphate	phosphate	NOUN
admet-661	44	55	buffer	buffer	NOUN
admet-661	44	56	)	)	PUNCT
admet-661	44	57	and	and	CCONJ
admet-661	44	58	observed	observe	VERB
admet-661	44	59	that	that	SCONJ
admet-661	44	60	,	,	PUNCT
admet-661	44	61	as	as	SCONJ
admet-661	44	62	compared	compare	VERB
admet-661	44	63	to	to	ADP
admet-661	44	64	the	the	DET
admet-661	44	65	free	free	ADJ
admet-661	44	66	base	base	NOUN
admet-661	44	67	solubility	solubility	NOUN
admet-661	44	68	of	of	ADP
admet-661	44	69	5	5	NUM
admet-661	44	70	µg	µg	ADV
admet-661	44	71	/	/	SYM
admet-661	44	72	ml	ml	NOUN
admet-661	44	73	,	,	PUNCT
admet-661	44	74	the	the	DET
admet-661	44	75	solubility	solubility	NOUN
admet-661	44	76	of	of	ADP
admet-661	44	77	the	the	DET
admet-661	44	78	cocrystals	cocrystal	NOUN
admet-661	44	79	ranged	range	VERB
admet-661	44	80	from	from	ADP
admet-661	44	81	1	1	NUM
admet-661	44	82	to	to	PART
admet-661	44	83	21	21	NUM
admet-661	44	84	µg	µg	NOUN
admet-661	44	85	/	/	SYM
admet-661	44	86	ml	ml	NOUN
admet-661	44	87	.	.	PUNCT
admet-661	45	1	thus	thus	ADV
admet-661	45	2	,	,	PUNCT
admet-661	45	3	the	the	DET
admet-661	45	4	solubility	solubility	NOUN
admet-661	45	5	of	of	ADP
admet-661	45	6	the	the	DET
admet-661	45	7	compound	compound	NOUN
admet-661	45	8	either	either	CCONJ
admet-661	45	9	decreased	decrease	VERB
admet-661	45	10	or	or	CCONJ
admet-661	45	11	only	only	ADV
admet-661	45	12	marginally	marginally	ADV
admet-661	45	13	increased	increase	VERB
admet-661	45	14	.	.	PUNCT
admet-661	46	1	in	in	ADP
admet-661	46	2	another	another	DET
admet-661	46	3	study	study	NOUN
admet-661	46	4	[	[	X
admet-661	46	5	18	18	NUM
admet-661	46	6	]	]	PUNCT
admet-661	46	7	,	,	PUNCT
admet-661	46	8	the	the	DET
admet-661	46	9	solubility	solubility	NOUN
admet-661	46	10	of	of	ADP
admet-661	46	11	a	a	DET
admet-661	46	12	basic	basic	ADJ
admet-661	46	13	drug	drug	NOUN
admet-661	46	14	,	,	PUNCT
admet-661	46	15	lamotrigine	lamotrigine	NOUN
admet-661	46	16	,	,	PUNCT
admet-661	46	17	in	in	ADP
admet-661	46	18	water	water	NOUN
admet-661	46	19	was	be	AUX
admet-661	46	20	0.154	0.154	NUM
admet-661	46	21	mg	mg	PROPN
admet-661	46	22	/	/	SYM
admet-661	46	23	ml	ml	NOUN
admet-661	46	24	,	,	PUNCT
admet-661	46	25	while	while	SCONJ
admet-661	46	26	the	the	DET
admet-661	46	27	solubility	solubility	NOUN
admet-661	46	28	of	of	ADP
admet-661	46	29	its	its	PRON
admet-661	46	30	cocrystals	cocrystal	NOUN
admet-661	46	31	with	with	ADP
admet-661	46	32	glutaric	glutaric	ADJ
admet-661	46	33	acid	acid	NOUN
admet-661	46	34	,	,	PUNCT
admet-661	46	35	sorbic	sorbic	NOUN
admet-661	46	36	acid	acid	NOUN
admet-661	46	37	,	,	PUNCT
admet-661	46	38	propionic	propionic	ADJ
admet-661	46	39	acid	acid	NOUN
admet-661	46	40	and	and	CCONJ
admet-661	46	41	acetic	acetic	ADJ
admet-661	46	42	acid	acid	NOUN
admet-661	46	43	increased	increase	VERB
admet-661	46	44	to	to	ADP
admet-661	46	45	1.10	1.10	NUM
admet-661	46	46	,	,	PUNCT
admet-661	46	47	1.12	1.12	NUM
admet-661	46	48	,	,	PUNCT
admet-661	46	49	2.17	2.17	NUM
admet-661	46	50	and	and	CCONJ
admet-661	46	51	2.55	2.55	NUM
admet-661	46	52	mg	mg	NUM
admet-661	46	53	/	/	SYM
admet-661	46	54	ml	ml	NOUN
admet-661	46	55	,	,	PUNCT
admet-661	46	56	respectively	respectively	ADV
admet-661	46	57	,	,	PUNCT
admet-661	46	58	and	and	CCONJ
admet-661	46	59	,	,	PUNCT
admet-661	46	60	thus	thus	ADV
admet-661	46	61	,	,	PUNCT
admet-661	46	62	there	there	PRON
admet-661	46	63	were	be	VERB
admet-661	46	64	7	7	NUM
admet-661	46	65	to	to	PART
admet-661	46	66	17	17	NUM
admet-661	46	67	times	time	NOUN
admet-661	46	68	increase	increase	NOUN
admet-661	46	69	in	in	ADP
admet-661	46	70	aqueous	aqueous	ADJ
admet-661	46	71	solubility	solubility	NOUN
admet-661	46	72	.	.	PUNCT
admet-661	47	1	however	however	ADV
admet-661	47	2	,	,	PUNCT
admet-661	47	3	at	at	ADP
admet-661	47	4	the	the	DET
admet-661	47	5	same	same	ADJ
admet-661	47	6	time	time	NOUN
admet-661	47	7	,	,	PUNCT
admet-661	47	8	ph	ph	NOUN
admet-661	47	9	of	of	ADP
admet-661	47	10	the	the	DET
admet-661	47	11	aqueous	aqueous	ADJ
admet-661	47	12	slurries	slurry	NOUN
admet-661	47	13	during	during	ADP
admet-661	47	14	the	the	DET
admet-661	47	15	determination	determination	NOUN
admet-661	47	16	of	of	ADP
admet-661	47	17	solubility	solubility	NOUN
admet-661	47	18	decreased	decrease	VERB
admet-661	47	19	from	from	ADP
admet-661	47	20	6.8	6.8	NUM
admet-661	47	21	for	for	ADP
admet-661	47	22	the	the	DET
admet-661	47	23	free	free	ADJ
admet-661	47	24	base	base	NOUN
admet-661	47	25	to	to	ADP
admet-661	47	26	,	,	PUNCT
admet-661	47	27	respectively	respectively	ADV
admet-661	47	28	,	,	PUNCT
admet-661	47	29	5.2	5.2	NUM
admet-661	47	30	,	,	PUNCT
admet-661	47	31	5.1	5.1	NUM
admet-661	47	32	,	,	PUNCT
admet-661	47	33	5.0	5.0	NUM
admet-661	47	34	and	and	CCONJ
admet-661	47	35	4.9	4.9	NUM
admet-661	47	36	for	for	ADP
admet-661	47	37	the	the	DET
admet-661	47	38	four	four	NUM
admet-661	47	39	cocrystals	cocrystal	NOUN
admet-661	47	40	.	.	PUNCT
admet-661	48	1	since	since	SCONJ
admet-661	48	2	lamotrigine	lamotrigine	PROPN
admet-661	48	3	has	have	VERB
admet-661	48	4	a	a	DET
admet-661	48	5	pka	pka	NOUN
admet-661	48	6	value	value	NOUN
admet-661	48	7	of	of	ADP
admet-661	48	8	5.7	5.7	NUM
admet-661	48	9	,	,	PUNCT
admet-661	48	10	the	the	DET
admet-661	48	11	increase	increase	NOUN
admet-661	48	12	in	in	ADP
admet-661	48	13	its	its	PRON
admet-661	48	14	aqueous	aqueous	ADJ
admet-661	48	15	solubility	solubility	NOUN
admet-661	48	16	by	by	ADP
admet-661	48	17	the	the	DET
admet-661	48	18	formation	formation	NOUN
admet-661	48	19	of	of	ADP
admet-661	48	20	cocrystals	cocrystal	NOUN
admet-661	48	21	may	may	AUX
admet-661	48	22	be	be	AUX
admet-661	48	23	attributed	attribute	VERB
admet-661	48	24	partly	partly	ADV
admet-661	48	25	or	or	CCONJ
admet-661	48	26	fully	fully	ADV
admet-661	48	27	to	to	ADP
admet-661	48	28	the	the	DET
admet-661	48	29	ph	ph	ADJ
admet-661	48	30	change	change	NOUN
admet-661	48	31	and	and	CCONJ
admet-661	48	32	the	the	DET
admet-661	48	33	resultant	resultant	NOUN
admet-661	48	34	protonation	protonation	NOUN
admet-661	48	35	of	of	ADP
admet-661	48	36	the	the	DET
admet-661	48	37	compound	compound	NOUN
admet-661	48	38	rather	rather	ADV
admet-661	48	39	than	than	ADP
admet-661	48	40	cocrystal	cocrystal	ADJ
admet-661	48	41	formation	formation	NOUN
admet-661	48	42	.	.	PUNCT
admet-661	49	1	similarly	similarly	ADV
admet-661	49	2	,	,	PUNCT
admet-661	49	3	gao	gao	PROPN
admet-661	49	4	et	et	PROPN
admet-661	49	5	al	al	PROPN
admet-661	49	6	.	.	PUNCT
admet-661	50	1	[	[	X
admet-661	50	2	19	19	NUM
admet-661	50	3	]	]	PUNCT
admet-661	50	4	observed	observe	VERB
admet-661	50	5	a	a	DET
admet-661	50	6	four	four	NUM
admet-661	50	7	-	-	ADJ
admet-661	50	8	fold	fold	ADJ
admet-661	50	9	increase	increase	NOUN
admet-661	50	10	in	in	ADP
admet-661	50	11	solubility	solubility	NOUN
admet-661	50	12	of	of	ADP
admet-661	50	13	adefovir	adefovir	PROPN
admet-661	50	14	dipivoxil	dipivoxil	PROPN
admet-661	50	15	,	,	PUNCT
admet-661	50	16	a	a	DET
admet-661	50	17	basic	basic	ADJ
admet-661	50	18	drug	drug	NOUN
admet-661	50	19	,	,	PUNCT
admet-661	50	20	in	in	ADP
admet-661	50	21	water	water	NOUN
admet-661	50	22	from	from	ADP
admet-661	50	23	0.79	0.79	NUM
admet-661	50	24	mmol	mmol	NOUN
admet-661	50	25	/	/	SYM
admet-661	50	26	l	l	NOUN
admet-661	50	27	to	to	ADP
admet-661	50	28	3.33	3.33	NUM
admet-661	50	29	mmol	mmol	NOUN
admet-661	50	30	/	/	SYM
admet-661	50	31	l	l	NOUN
admet-661	50	32	due	due	ADP
admet-661	50	33	to	to	PART
admet-661	50	34	cocrystal	cocrystal	ADJ
admet-661	50	35	formation	formation	NOUN
admet-661	50	36	with	with	ADP
admet-661	50	37	saccharin	saccharin	NOUN
admet-661	50	38	that	that	PRON
admet-661	50	39	may	may	AUX
admet-661	50	40	also	also	ADV
admet-661	50	41	be	be	AUX
admet-661	50	42	attributed	attribute	VERB
admet-661	50	43	to	to	ADP
admet-661	50	44	the	the	DET
admet-661	50	45	decrease	decrease	NOUN
admet-661	50	46	in	in	ADP
admet-661	50	47	ph	ph	NOUN
admet-661	50	48	of	of	ADP
admet-661	50	49	saturated	saturate	VERB
admet-661	50	50	solutions	solution	NOUN
admet-661	50	51	from	from	ADP
admet-661	50	52	6.7	6.7	NUM
admet-661	50	53	to	to	PART
admet-661	50	54	3.1	3.1	NUM
admet-661	50	55	.	.	PUNCT
admet-661	51	1	cheney	cheney	PROPN
admet-661	51	2	et	et	PROPN
admet-661	51	3	al	al	PROPN
admet-661	51	4	.	.	PUNCT
admet-661	52	1	[	[	X
admet-661	52	2	20	20	NUM
admet-661	52	3	]	]	PUNCT
admet-661	52	4	found	find	VERB
admet-661	52	5	that	that	SCONJ
admet-661	52	6	when	when	SCONJ
admet-661	52	7	there	there	PRON
admet-661	52	8	was	be	VERB
admet-661	52	9	no	no	DET
admet-661	52	10	difference	difference	NOUN
admet-661	52	11	in	in	ADP
admet-661	52	12	ph	ph	NOUN
admet-661	52	13	of	of	ADP
admet-661	52	14	saturated	saturate	VERB
admet-661	52	15	solutions	solution	NOUN
admet-661	52	16	,	,	PUNCT
admet-661	52	17	there	there	PRON
admet-661	52	18	was	be	VERB
admet-661	52	19	also	also	ADV
admet-661	52	20	no	no	DET
admet-661	52	21	significant	significant	ADJ
admet-661	52	22	difference	difference	NOUN
admet-661	52	23	among	among	ADP
admet-661	52	24	solubilities	solubility	NOUN
admet-661	52	25	of	of	ADP
admet-661	52	26	free	free	ADJ
admet-661	52	27	base	base	NOUN
admet-661	52	28	and	and	CCONJ
admet-661	52	29	cocrystals	cocrystal	NOUN
admet-661	52	30	forms	form	NOUN
admet-661	52	31	of	of	ADP
admet-661	52	32	drug	drug	NOUN
admet-661	52	33	.	.	PUNCT
admet-661	53	1	in	in	ADP
admet-661	53	2	this	this	DET
admet-661	53	3	case	case	NOUN
admet-661	53	4	,	,	PUNCT
admet-661	53	5	solubilities	solubility	NOUN
admet-661	53	6	of	of	ADP
admet-661	53	7	lamotrigine	lamotrigine	NOUN
admet-661	53	8	-	-	PUNCT
admet-661	53	9	methyl	methyl	NOUN
admet-661	53	10	paraben	paraben	NOUN
admet-661	53	11	,	,	PUNCT
admet-661	53	12	lamotriginenicotinamide	lamotriginenicotinamide	ADJ
admet-661	53	13	and	and	CCONJ
admet-661	53	14	lamotrigine	lamotrigine	NOUN
admet-661	53	15	-	-	PUNCT
admet-661	53	16	nicotinamide	nicotinamide	NOUN
admet-661	53	17	(	(	PUNCT
admet-661	53	18	monohydrate	monohydrate	NOUN
admet-661	53	19	)	)	PUNCT
admet-661	53	20	cocrystals	cocrystal	NOUN
admet-661	53	21	at	at	ADP
admet-661	53	22	1:1	1:1	NUM
admet-661	53	23	ratios	ratio	NOUN
admet-661	53	24	and	and	CCONJ
admet-661	53	25	that	that	PRON
admet-661	53	26	of	of	ADP
admet-661	53	27	the	the	DET
admet-661	53	28	lamotrigine	lamotrigine	ADJ
admet-661	53	29	free	free	ADJ
admet-661	53	30	base	base	NOUN
admet-661	53	31	in	in	ADP
admet-661	53	32	water	water	NOUN
admet-661	53	33	,	,	PUNCT
admet-661	53	34	all	all	PRON
admet-661	53	35	having	have	VERB
admet-661	53	36	ph	ph	NOUN
admet-661	53	37	of	of	ADP
admet-661	53	38	~5.5	~5.5	PRON
admet-661	53	39	,	,	PUNCT
admet-661	53	40	were	be	AUX
admet-661	53	41	,	,	PUNCT
admet-661	53	42	respectively	respectively	ADV
admet-661	53	43	,	,	PUNCT
admet-661	53	44	0.21	0.21	NUM
admet-661	53	45	,	,	PUNCT
admet-661	53	46	0.30	0.30	NUM
admet-661	53	47	,	,	PUNCT
admet-661	53	48	0.23	0.23	NUM
admet-661	53	49	and	and	CCONJ
admet-661	53	50	0.28	0.28	NUM
admet-661	53	51	mg	mg	NUM
admet-661	53	52	/	/	SYM
admet-661	53	53	ml	ml	PROPN
admet-661	53	54	,	,	PUNCT
admet-661	53	55	indicating	indicate	VERB
admet-661	53	56	no	no	DET
admet-661	53	57	significant	significant	ADJ
admet-661	53	58	difference	difference	NOUN
admet-661	53	59	in	in	ADP
admet-661	53	60	solubility	solubility	NOUN
admet-661	53	61	due	due	ADP
admet-661	53	62	to	to	ADP
admet-661	53	63	cocrystal	cocrystal	ADJ
admet-661	53	64	formation	formation	NOUN
admet-661	53	65	.	.	PUNCT
admet-661	54	1	in	in	ADP
admet-661	54	2	another	another	DET
admet-661	54	3	study	study	NOUN
admet-661	54	4	,	,	PUNCT
admet-661	54	5	ràfols	ràfol	VERB
admet-661	54	6	et	et	PROPN
admet-661	54	7	al	al	PROPN
admet-661	54	8	.	.	PUNCT
admet-661	55	1	[	[	X
admet-661	55	2	21	21	NUM
admet-661	55	3	]	]	PUNCT
admet-661	55	4	compared	compare	VERB
admet-661	55	5	dissolution	dissolution	NOUN
admet-661	55	6	rates	rate	NOUN
admet-661	55	7	of	of	ADP
admet-661	55	8	a	a	DET
admet-661	55	9	zwitterionic	zwitterionic	ADJ
admet-661	55	10	compound	compound	NOUN
admet-661	55	11	,	,	PUNCT
admet-661	55	12	ciprofloxacin	ciprofloxacin	NOUN
admet-661	55	13	,	,	PUNCT
admet-661	55	14	and	and	CCONJ
admet-661	55	15	its	its	PRON
admet-661	55	16	cocrystal	cocrystal	NOUN
admet-661	55	17	with	with	ADP
admet-661	55	18	resorcinol	resorcinol	NOUN
admet-661	55	19	under	under	ADP
admet-661	55	20	different	different	ADJ
admet-661	55	21	ph	ph	ADJ
admet-661	55	22	conditions	condition	NOUN
admet-661	55	23	and	and	CCONJ
admet-661	55	24	observed	observe	VERB
admet-661	55	25	that	that	SCONJ
admet-661	55	26	the	the	DET
admet-661	55	27	parent	parent	NOUN
admet-661	55	28	compound	compound	NOUN
admet-661	55	29	dissolved	dissolve	VERB
admet-661	55	30	faster	fast	ADV
admet-661	55	31	at	at	ADP
admet-661	55	32	ph	ph	ADJ
admet-661	55	33	2	2	NUM
admet-661	55	34	,	,	PUNCT
admet-661	55	35	while	while	SCONJ
admet-661	55	36	the	the	DET
admet-661	55	37	cocrystal	cocrystal	NOUN
admet-661	55	38	had	have	VERB
admet-661	55	39	somewhat	somewhat	ADV
admet-661	55	40	higher	high	ADJ
admet-661	55	41	dissolution	dissolution	NOUN
admet-661	55	42	rates	rate	NOUN
admet-661	55	43	in	in	ADP
admet-661	55	44	the	the	DET
admet-661	55	45	intermediate	intermediate	ADJ
admet-661	55	46	ph	ph	ADJ
admet-661	55	47	conditions	condition	NOUN
admet-661	55	48	of	of	ADP
admet-661	55	49	4	4	NUM
admet-661	55	50	,	,	PUNCT
admet-661	55	51	5	5	NUM
admet-661	55	52	and	and	CCONJ
admet-661	55	53	5.5	5.5	NUM
admet-661	55	54	.	.	PUNCT
admet-661	56	1	however	however	ADV
admet-661	56	2	,	,	PUNCT
admet-661	56	3	at	at	ADP
admet-661	56	4	the	the	DET
admet-661	56	5	intestinal	intestinal	ADJ
admet-661	56	6	ph	ph	ADJ
admet-661	56	7	condition	condition	NOUN
admet-661	56	8	of	of	ADP
admet-661	56	9	6.5	6.5	NUM
admet-661	56	10	,	,	PUNCT
admet-661	56	11	both	both	DET
admet-661	56	12	ciprofloxacin	ciprofloxacin	NOUN
admet-661	56	13	and	and	CCONJ
admet-661	56	14	the	the	DET
admet-661	56	15	cocrystal	cocrystal	NOUN
admet-661	56	16	had	have	VERB
admet-661	56	17	much	much	ADV
admet-661	56	18	lower	low	ADJ
admet-661	56	19	and	and	CCONJ
admet-661	56	20	essentially	essentially	ADV
admet-661	56	21	similar	similar	ADJ
admet-661	56	22	solubility	solubility	NOUN
admet-661	56	23	and	and	CCONJ
admet-661	56	24	dissolution	dissolution	NOUN
admet-661	56	25	rates	rate	NOUN
admet-661	56	26	irrespective	irrespective	ADV
admet-661	56	27	of	of	ADP
admet-661	56	28	whether	whether	SCONJ
admet-661	56	29	the	the	DET
admet-661	56	30	studies	study	NOUN
admet-661	56	31	were	be	AUX
admet-661	56	32	conducted	conduct	VERB
admet-661	56	33	in	in	ADP
admet-661	56	34	buffer	buffer	NOUN
admet-661	56	35	or	or	CCONJ
admet-661	56	36	fasted	fast	VERB
admet-661	56	37	state	state	NOUN
admet-661	56	38	simulated	simulate	VERB
admet-661	56	39	intestinal	intestinal	ADJ
admet-661	56	40	fluid	fluid	NOUN
admet-661	56	41	(	(	PUNCT
admet-661	56	42	fassif	fassif	NOUN
admet-661	56	43	)	)	PUNCT
admet-661	56	44	,	,	PUNCT
admet-661	56	45	indicating	indicate	VERB
admet-661	56	46	that	that	SCONJ
admet-661	56	47	there	there	PRON
admet-661	56	48	were	be	VERB
admet-661	56	49	no	no	DET
admet-661	56	50	solubility	solubility	NOUN
admet-661	56	51	and	and	CCONJ
admet-661	56	52	dissolution	dissolution	NOUN
admet-661	56	53	advantages	advantage	NOUN
admet-661	56	54	of	of	ADP
admet-661	56	55	cocrystal	cocrystal	ADJ
admet-661	56	56	formation	formation	NOUN
admet-661	56	57	under	under	ADP
admet-661	56	58	intestinal	intestinal	ADJ
admet-661	56	59	ph	ph	ADJ
admet-661	56	60	conditions	condition	NOUN
admet-661	56	61	.	.	PUNCT
admet-661	57	1	the	the	DET
admet-661	57	2	above	above	ADJ
admet-661	57	3	review	review	NOUN
admet-661	57	4	of	of	ADP
admet-661	57	5	published	publish	VERB
admet-661	57	6	studies	study	NOUN
admet-661	57	7	does	do	AUX
admet-661	57	8	not	not	PART
admet-661	57	9	show	show	VERB
admet-661	57	10	any	any	DET
admet-661	57	11	major	major	ADJ
admet-661	57	12	difference	difference	NOUN
admet-661	57	13	in	in	ADP
admet-661	57	14	equilibrium	equilibrium	NOUN
admet-661	57	15	solubility	solubility	NOUN
admet-661	57	16	between	between	ADP
admet-661	57	17	cocrystal	cocrystal	ADJ
admet-661	57	18	and	and	CCONJ
admet-661	57	19	neutral	neutral	ADJ
admet-661	57	20	chemical	chemical	NOUN
admet-661	57	21	entity	entity	NOUN
admet-661	57	22	or	or	CCONJ
admet-661	57	23	between	between	ADP
admet-661	57	24	cocrystal	cocrystal	ADJ
admet-661	57	25	and	and	CCONJ
admet-661	57	26	free	free	ADJ
admet-661	57	27	base	base	NOUN
admet-661	57	28	in	in	ADP
admet-661	57	29	aqueous	aqueous	ADJ
admet-661	57	30	media	medium	NOUN
admet-661	57	31	,	,	PUNCT
admet-661	57	32	and	and	CCONJ
admet-661	57	33	where	where	SCONJ
admet-661	57	34	a	a	DET
admet-661	57	35	difference	difference	NOUN
admet-661	57	36	was	be	AUX
admet-661	57	37	observed	observe	VERB
admet-661	57	38	,	,	PUNCT
admet-661	57	39	it	it	PRON
admet-661	57	40	could	could	AUX
admet-661	57	41	possibly	possibly	ADV
admet-661	57	42	be	be	AUX
admet-661	57	43	explained	explain	VERB
admet-661	57	44	by	by	ADP
admet-661	57	45	the	the	DET
admet-661	57	46	change	change	NOUN
admet-661	57	47	in	in	ADP
admet-661	57	48	ph	ph	NOUN
admet-661	57	49	of	of	ADP
admet-661	57	50	solutions	solution	NOUN
admet-661	57	51	.	.	PUNCT
admet-661	58	1	there	there	PRON
admet-661	58	2	are	be	VERB
admet-661	58	3	,	,	PUNCT
admet-661	58	4	however	however	ADV
admet-661	58	5	,	,	PUNCT
admet-661	58	6	several	several	ADJ
admet-661	58	7	reports	report	NOUN
admet-661	58	8	where	where	SCONJ
admet-661	58	9	differences	difference	NOUN
admet-661	58	10	between	between	ADP
admet-661	58	11	kinetic	kinetic	ADJ
admet-661	58	12	solubility	solubility	NOUN
admet-661	58	13	of	of	ADP
admet-661	58	14	cocrystals	cocrystal	NOUN
admet-661	58	15	and	and	CCONJ
admet-661	58	16	free	free	ADJ
admet-661	58	17	forms	form	NOUN
admet-661	58	18	of	of	ADP
admet-661	58	19	drug	drug	NOUN
admet-661	58	20	were	be	AUX
admet-661	58	21	observed	observe	VERB
admet-661	58	22	when	when	SCONJ
admet-661	58	23	dissolution	dissolution	ADJ
admet-661	58	24	rates	rate	NOUN
admet-661	58	25	of	of	ADP
admet-661	58	26	powders	powder	NOUN
admet-661	58	27	were	be	AUX
admet-661	58	28	studied	study	VERB
admet-661	58	29	.	.	PUNCT
admet-661	59	1	it	it	PRON
admet-661	59	2	was	be	AUX
admet-661	59	3	observed	observe	VERB
admet-661	59	4	that	that	SCONJ
admet-661	59	5	there	there	PRON
admet-661	59	6	were	be	VERB
admet-661	59	7	initial	initial	ADJ
admet-661	59	8	increases	increase	NOUN
admet-661	59	9	in	in	ADP
admet-661	59	10	drug	drug	NOUN
admet-661	59	11	concentrations	concentration	NOUN
admet-661	59	12	,	,	PUNCT
admet-661	59	13	which	which	PRON
admet-661	59	14	decreased	decrease	VERB
admet-661	59	15	with	with	ADP
admet-661	59	16	time	time	NOUN
admet-661	59	17	as	as	SCONJ
admet-661	59	18	the	the	DET
admet-661	59	19	free	free	ADJ
admet-661	59	20	base	base	NOUN
admet-661	59	21	forms	form	NOUN
admet-661	59	22	precipitated	precipitate	VERB
admet-661	59	23	out	out	ADP
admet-661	60	1	[	[	X
admet-661	60	2	17,22,23	17,22,23	NUM
admet-661	60	3	]	]	PUNCT
admet-661	60	4	.	.	PUNCT
admet-661	61	1	this	this	PRON
admet-661	61	2	is	be	AUX
admet-661	61	3	analogous	analogous	ADJ
admet-661	61	4	to	to	ADP
admet-661	61	5	the	the	DET
admet-661	61	6	supersaturation	supersaturation	NOUN
admet-661	61	7	of	of	ADP
admet-661	61	8	amorphous	amorphous	ADJ
admet-661	61	9	drugs	drug	NOUN
admet-661	61	10	prior	prior	ADV
admet-661	61	11	to	to	ADP
admet-661	61	12	their	their	PRON
admet-661	61	13	conversion	conversion	NOUN
admet-661	61	14	to	to	ADP
admet-661	61	15	crystalline	crystalline	VERB
admet-661	61	16	forms	form	NOUN
admet-661	61	17	[	[	X
admet-661	61	18	24	24	NUM
admet-661	61	19	]	]	X
admet-661	61	20	;	;	PUNCT
admet-661	61	21	when	when	SCONJ
admet-661	61	22	the	the	DET
admet-661	61	23	solubility	solubility	NOUN
admet-661	61	24	reaches	reach	VERB
admet-661	61	25	equilibrium	equilibrium	NOUN
admet-661	61	26	,	,	PUNCT
admet-661	61	27	any	any	DET
admet-661	61	28	difference	difference	NOUN
admet-661	61	29	between	between	ADP
admet-661	61	30	solubility	solubility	NOUN
admet-661	61	31	of	of	ADP
admet-661	61	32	cocrystal	cocrystal	ADJ
admet-661	61	33	and	and	CCONJ
admet-661	61	34	free	free	ADJ
admet-661	61	35	drug	drug	NOUN
admet-661	61	36	form	form	NOUN
admet-661	61	37	diminishes	diminish	VERB
admet-661	61	38	or	or	CCONJ
admet-661	61	39	disappears	disappear	VERB
admet-661	61	40	.	.	PUNCT
admet-661	62	1	in	in	ADP
admet-661	62	2	contrast	contrast	NOUN
admet-661	62	3	to	to	ADP
admet-661	62	4	the	the	DET
admet-661	62	5	above	above	ADV
admet-661	62	6	-	-	PUNCT
admet-661	62	7	mentioned	mention	VERB
admet-661	62	8	experimental	experimental	ADJ
admet-661	62	9	findings	finding	NOUN
admet-661	62	10	,	,	PUNCT
admet-661	62	11	several	several	ADJ
admet-661	62	12	investigators	investigator	NOUN
admet-661	62	13	have	have	AUX
admet-661	62	14	demonstrated	demonstrate	VERB
admet-661	62	15	through	through	ADP
admet-661	62	16	a	a	DET
admet-661	62	17	combination	combination	NOUN
admet-661	62	18	of	of	ADP
admet-661	62	19	experimental	experimental	ADJ
admet-661	62	20	studies	study	NOUN
admet-661	62	21	and	and	CCONJ
admet-661	62	22	theoretical	theoretical	ADJ
admet-661	62	23	calculations	calculation	NOUN
admet-661	62	24	that	that	SCONJ
admet-661	62	25	cocrystals	cocrystal	NOUN
admet-661	62	26	can	can	AUX
admet-661	62	27	indeed	indeed	ADV
admet-661	62	28	have	have	VERB
admet-661	62	29	major	major	ADJ
admet-661	62	30	solubility	solubility	NOUN
admet-661	62	31	advantages	advantage	NOUN
admet-661	62	32	over	over	ADP
admet-661	62	33	their	their	PRON
admet-661	62	34	respective	respective	ADJ
admet-661	62	35	free	free	ADJ
admet-661	62	36	forms	form	NOUN
admet-661	62	37	,	,	PUNCT
admet-661	62	38	sometimes	sometimes	ADV
admet-661	62	39	by	by	ADP
admet-661	62	40	several	several	ADJ
admet-661	62	41	orders	order	NOUN
admet-661	62	42	in	in	ADP
admet-661	62	43	magnitude	magnitude	NOUN
admet-661	62	44	admet	admet	PROPN
admet-661	62	45	&	&	CCONJ
admet-661	62	46	dmpk	dmpk	PROPN
admet-661	62	47	7(2	7(2	NUM
admet-661	62	48	)	)	PUNCT
admet-661	62	49	(	(	PUNCT
admet-661	62	50	2019	2019	NUM
admet-661	62	51	)	)	PUNCT
admet-661	62	52	106	106	NUM
admet-661	62	53	-	-	SYM
admet-661	62	54	130	130	NUM
admet-661	62	55	solubility	solubility	NOUN
admet-661	62	56	and	and	CCONJ
admet-661	62	57	dissolution	dissolution	NOUN
admet-661	62	58	of	of	ADP
admet-661	62	59	cocrystals	cocrystal	NOUN
admet-661	62	60	doi	doi	NOUN
admet-661	62	61	:	:	PUNCT
admet-661	62	62	10.5599	10.5599	NUM
admet-661	62	63	/	/	SYM
admet-661	62	64	admet.661	admet.661	PROPN
admet-661	62	65	109	109	NUM
admet-661	63	1	[	[	X
admet-661	63	2	22,23,25,26	22,23,25,26	NUM
admet-661	63	3	]	]	PUNCT
admet-661	63	4	.	.	PUNCT
admet-661	64	1	the	the	DET
admet-661	64	2	higher	high	ADJ
admet-661	64	3	solubility	solubility	NOUN
admet-661	64	4	of	of	ADP
admet-661	64	5	cocrystals	cocrystal	NOUN
admet-661	64	6	as	as	SCONJ
admet-661	64	7	the	the	DET
admet-661	64	8	function	function	NOUN
admet-661	64	9	of	of	ADP
admet-661	64	10	ph	ph	NOUN
admet-661	64	11	in	in	ADP
admet-661	64	12	these	these	DET
admet-661	64	13	studies	study	NOUN
admet-661	64	14	were	be	AUX
admet-661	64	15	obtained	obtain	VERB
admet-661	64	16	by	by	ADP
admet-661	64	17	applying	apply	VERB
admet-661	64	18	a	a	DET
admet-661	64	19	new	new	ADJ
admet-661	64	20	3	3	NUM
admet-661	64	21	-	-	PUNCT
admet-661	64	22	step	step	NOUN
admet-661	64	23	process	process	NOUN
admet-661	64	24	:	:	PUNCT
admet-661	64	25	first	first	ADV
admet-661	64	26	,	,	PUNCT
admet-661	64	27	drug	drug	NOUN
admet-661	64	28	and	and	CCONJ
admet-661	64	29	coformer	coformer	NOUN
admet-661	64	30	concentrations	concentration	NOUN
admet-661	64	31	in	in	ADP
admet-661	64	32	equilibria	equilibrium	NOUN
admet-661	64	33	with	with	ADP
admet-661	64	34	cocrystals	cocrystal	NOUN
admet-661	64	35	were	be	AUX
admet-661	64	36	measured	measure	VERB
admet-661	64	37	at	at	ADP
admet-661	64	38	ph	ph	ADJ
admet-661	64	39	values	value	NOUN
admet-661	64	40	of	of	ADP
admet-661	64	41	interest	interest	NOUN
admet-661	64	42	;	;	PUNCT
admet-661	64	43	second	second	ADJ
admet-661	64	44	,	,	PUNCT
admet-661	64	45	cocrystal	cocrystal	ADJ
admet-661	64	46	solubility	solubility	NOUN
admet-661	64	47	and	and	CCONJ
admet-661	64	48	solubility	solubility	NOUN
admet-661	64	49	product	product	NOUN
admet-661	64	50	(	(	PUNCT
admet-661	64	51	ksp	ksp	PROPN
admet-661	64	52	)	)	PUNCT
admet-661	64	53	were	be	AUX
admet-661	64	54	determined	determine	VERB
admet-661	64	55	from	from	ADP
admet-661	64	56	the	the	DET
admet-661	64	57	measured	measured	ADJ
admet-661	64	58	equilibrium	equilibrium	NOUN
admet-661	64	59	concentrations	concentration	NOUN
admet-661	64	60	;	;	PUNCT
admet-661	64	61	and	and	CCONJ
admet-661	64	62	,	,	PUNCT
admet-661	64	63	third	third	ADJ
admet-661	64	64	,	,	PUNCT
admet-661	64	65	the	the	DET
admet-661	64	66	ph	ph	ADJ
admet-661	64	67	dependence	dependence	NOUN
admet-661	64	68	of	of	ADP
admet-661	64	69	cocrystal	cocrystal	ADJ
admet-661	64	70	solubility	solubility	NOUN
admet-661	64	71	is	be	AUX
admet-661	64	72	theoretically	theoretically	ADV
admet-661	64	73	calculated	calculate	VERB
admet-661	64	74	from	from	ADP
admet-661	64	75	ksp	ksp	PROPN
admet-661	64	76	of	of	ADP
admet-661	64	77	cocrystal	cocrystal	PROPN
admet-661	64	78	,	,	PUNCT
admet-661	64	79	pka	pka	PROPN
admet-661	64	80	values	value	NOUN
admet-661	64	81	of	of	ADP
admet-661	64	82	drug	drug	NOUN
admet-661	64	83	and	and	CCONJ
admet-661	64	84	coformer	coformer	NOUN
admet-661	64	85	,	,	PUNCT
admet-661	64	86	and	and	CCONJ
admet-661	64	87	corresponding	correspond	VERB
admet-661	64	88	solubility	solubility	NOUN
admet-661	64	89	equations	equation	NOUN
admet-661	65	1	[	[	X
admet-661	65	2	22	22	NUM
admet-661	65	3	]	]	PUNCT
admet-661	65	4	.	.	PUNCT
admet-661	66	1	based	base	VERB
admet-661	66	2	on	on	ADP
admet-661	66	3	such	such	ADJ
admet-661	66	4	theoretical	theoretical	ADJ
admet-661	66	5	calculations	calculation	NOUN
admet-661	66	6	,	,	PUNCT
admet-661	66	7	chen	chen	PROPN
admet-661	66	8	et	et	PROPN
admet-661	66	9	al	al	PROPN
admet-661	66	10	.	.	PUNCT
admet-661	67	1	[	[	X
admet-661	67	2	22	22	NUM
admet-661	67	3	]	]	PUNCT
admet-661	67	4	observed	observe	VERB
admet-661	67	5	much	much	ADV
admet-661	67	6	higher	high	ADJ
admet-661	67	7	solubility	solubility	NOUN
admet-661	67	8	for	for	ADP
admet-661	67	9	1:1	1:1	NUM
admet-661	67	10	cocrystals	cocrystal	NOUN
admet-661	67	11	of	of	ADP
admet-661	67	12	ketoconazole	ketoconazole	NOUN
admet-661	67	13	,	,	PUNCT
admet-661	67	14	a	a	DET
admet-661	67	15	basic	basic	ADJ
admet-661	67	16	drug	drug	NOUN
admet-661	67	17	(	(	PUNCT
admet-661	67	18	pka	pka	PROPN
admet-661	67	19	2.94	2.94	NUM
admet-661	67	20	and	and	CCONJ
admet-661	67	21	6.51	6.51	NUM
admet-661	67	22	)	)	PUNCT
admet-661	68	1	[	[	X
admet-661	68	2	27	27	NUM
admet-661	68	3	]	]	PUNCT
admet-661	68	4	,	,	PUNCT
admet-661	68	5	with	with	ADP
admet-661	68	6	fumaric	fumaric	ADJ
admet-661	68	7	acid	acid	NOUN
admet-661	68	8	,	,	PUNCT
admet-661	68	9	succinic	succinic	ADJ
admet-661	68	10	acid	acid	NOUN
admet-661	68	11	and	and	CCONJ
admet-661	68	12	adipic	adipic	ADJ
admet-661	68	13	acid	acid	NOUN
admet-661	68	14	in	in	ADP
admet-661	68	15	the	the	DET
admet-661	68	16	ph	ph	ADJ
admet-661	68	17	range	range	NOUN
admet-661	68	18	of	of	ADP
admet-661	68	19	4	4	NUM
admet-661	68	20	to	to	PART
admet-661	68	21	7	7	NUM
admet-661	68	22	as	as	SCONJ
admet-661	68	23	compared	compare	VERB
admet-661	68	24	to	to	ADP
admet-661	68	25	that	that	PRON
admet-661	68	26	of	of	ADP
admet-661	68	27	the	the	DET
admet-661	68	28	free	free	ADJ
admet-661	68	29	base	base	NOUN
admet-661	68	30	in	in	ADP
admet-661	68	31	the	the	DET
admet-661	68	32	same	same	ADJ
admet-661	68	33	ph	ph	ADJ
admet-661	68	34	range	range	NOUN
admet-661	68	35	.	.	PUNCT
admet-661	69	1	martin	martin	PROPN
admet-661	69	2	et	et	PROPN
admet-661	69	3	al	al	PROPN
admet-661	69	4	.	.	PUNCT
admet-661	70	1	[	[	X
admet-661	70	2	28	28	NUM
admet-661	70	3	]	]	PUNCT
admet-661	70	4	also	also	ADV
admet-661	70	5	observed	observe	VERB
admet-661	70	6	75	75	NUM
admet-661	70	7	to	to	PART
admet-661	70	8	100	100	NUM
admet-661	70	9	times	time	NOUN
admet-661	70	10	higher	high	ADJ
admet-661	70	11	solubility	solubility	NOUN
admet-661	70	12	of	of	ADP
admet-661	70	13	ketoconazole	ketoconazole	PROPN
admet-661	70	14	cocrystals	cocrystal	NOUN
admet-661	70	15	with	with	ADP
admet-661	70	16	fumaric	fumaric	ADJ
admet-661	70	17	acid	acid	NOUN
admet-661	70	18	,	,	PUNCT
admet-661	70	19	succinic	succinic	ADJ
admet-661	70	20	acid	acid	NOUN
admet-661	70	21	and	and	CCONJ
admet-661	70	22	adipic	adipic	ADJ
admet-661	70	23	acid	acid	NOUN
admet-661	70	24	in	in	ADP
admet-661	70	25	water	water	NOUN
admet-661	70	26	than	than	ADP
admet-661	70	27	that	that	PRON
admet-661	70	28	of	of	ADP
admet-661	70	29	ketoconazole	ketoconazole	PROPN
admet-661	70	30	free	free	ADJ
admet-661	70	31	base	base	NOUN
admet-661	70	32	.	.	PUNCT
admet-661	71	1	however	however	ADV
admet-661	71	2	,	,	PUNCT
admet-661	71	3	in	in	ADP
admet-661	71	4	the	the	DET
admet-661	71	5	latter	latter	ADJ
admet-661	71	6	case	case	NOUN
admet-661	71	7	,	,	PUNCT
admet-661	71	8	the	the	DET
admet-661	71	9	ph	ph	ADJ
admet-661	71	10	values	value	NOUN
admet-661	71	11	of	of	ADP
admet-661	71	12	the	the	DET
admet-661	71	13	slurries	slurry	NOUN
admet-661	71	14	of	of	ADP
admet-661	71	15	cocrystals	cocrystal	NOUN
admet-661	71	16	in	in	ADP
admet-661	71	17	water	water	NOUN
admet-661	71	18	decreased	decrease	VERB
admet-661	71	19	from	from	ADP
admet-661	71	20	the	the	DET
admet-661	71	21	initial	initial	ADJ
admet-661	71	22	5.8	5.8	NUM
admet-661	71	23	to	to	ADP
admet-661	71	24	the	the	DET
admet-661	71	25	range	range	NOUN
admet-661	71	26	of	of	ADP
admet-661	71	27	3.4	3.4	NUM
admet-661	71	28	to	to	ADP
admet-661	71	29	4.1	4.1	NUM
admet-661	71	30	,	,	PUNCT
admet-661	71	31	where	where	SCONJ
admet-661	71	32	the	the	DET
admet-661	71	33	solubility	solubility	NOUN
admet-661	71	34	of	of	ADP
admet-661	71	35	the	the	DET
admet-661	71	36	drug	drug	NOUN
admet-661	71	37	could	could	AUX
admet-661	71	38	be	be	AUX
admet-661	71	39	much	much	ADV
admet-661	71	40	higher	high	ADJ
admet-661	71	41	and	and	CCONJ
admet-661	71	42	thus	thus	ADV
admet-661	71	43	be	be	AUX
admet-661	71	44	responsible	responsible	ADJ
admet-661	71	45	for	for	ADP
admet-661	71	46	the	the	DET
admet-661	71	47	observed	observe	VERB
admet-661	71	48	difference	difference	NOUN
admet-661	71	49	between	between	ADP
admet-661	71	50	cocrystal	cocrystal	ADJ
admet-661	71	51	and	and	CCONJ
admet-661	71	52	drug	drug	NOUN
admet-661	71	53	solubility	solubility	NOUN
admet-661	71	54	.	.	PUNCT
admet-661	72	1	the	the	DET
admet-661	72	2	inconsistencies	inconsistency	NOUN
admet-661	72	3	between	between	ADP
admet-661	72	4	above	above	ADV
admet-661	72	5	-	-	PUNCT
admet-661	72	6	mentioned	mention	VERB
admet-661	72	7	experimental	experimental	ADJ
admet-661	72	8	and	and	CCONJ
admet-661	72	9	theoretical	theoretical	ADJ
admet-661	72	10	findings	finding	NOUN
admet-661	72	11	indicate	indicate	VERB
admet-661	72	12	that	that	SCONJ
admet-661	72	13	much	much	ADJ
admet-661	72	14	additional	additional	ADJ
admet-661	72	15	work	work	NOUN
admet-661	72	16	is	be	AUX
admet-661	72	17	necessary	necessary	ADJ
admet-661	72	18	to	to	PART
admet-661	72	19	elucidate	elucidate	VERB
admet-661	72	20	what	what	PRON
admet-661	72	21	advantages	advantage	NOUN
admet-661	72	22	cocrystals	cocrystal	NOUN
admet-661	72	23	may	may	AUX
admet-661	72	24	have	have	VERB
admet-661	72	25	over	over	ADP
admet-661	72	26	their	their	PRON
admet-661	72	27	free	free	ADJ
admet-661	72	28	forms	form	NOUN
admet-661	72	29	with	with	ADP
admet-661	72	30	respect	respect	NOUN
admet-661	72	31	to	to	ADP
admet-661	72	32	solubility	solubility	NOUN
admet-661	72	33	and	and	CCONJ
admet-661	72	34	dissolution	dissolution	NOUN
admet-661	72	35	rate	rate	NOUN
admet-661	72	36	.	.	PUNCT
admet-661	73	1	therefore	therefore	ADV
admet-661	73	2	,	,	PUNCT
admet-661	73	3	the	the	DET
admet-661	73	4	present	present	ADJ
admet-661	73	5	investigation	investigation	NOUN
admet-661	73	6	has	have	AUX
admet-661	73	7	been	be	AUX
admet-661	73	8	undertaken	undertake	VERB
admet-661	73	9	to	to	AUX
admet-661	73	10	systematically	systematically	ADV
admet-661	73	11	determine	determine	VERB
admet-661	73	12	solubility	solubility	NOUN
admet-661	73	13	and	and	CCONJ
admet-661	73	14	dissolution	dissolution	NOUN
admet-661	73	15	rates	rate	NOUN
admet-661	73	16	of	of	ADP
admet-661	73	17	a	a	DET
admet-661	73	18	basic	basic	ADJ
admet-661	73	19	drug	drug	NOUN
admet-661	73	20	,	,	PUNCT
admet-661	73	21	ketoconazole	ketoconazole	NOUN
admet-661	73	22	,	,	PUNCT
admet-661	73	23	and	and	CCONJ
admet-661	73	24	two	two	NUM
admet-661	73	25	of	of	ADP
admet-661	73	26	its	its	PRON
admet-661	73	27	cocrystals	cocrystal	NOUN
admet-661	73	28	with	with	ADP
admet-661	73	29	fumaric	fumaric	ADJ
admet-661	73	30	acid	acid	PROPN
admet-661	73	31	and	and	CCONJ
admet-661	73	32	succinic	succinic	ADJ
admet-661	73	33	acid	acid	NOUN
admet-661	73	34	as	as	ADP
admet-661	73	35	functions	function	NOUN
admet-661	73	36	of	of	ADP
admet-661	73	37	ph	ph	NOUN
admet-661	73	38	.	.	PUNCT
admet-661	74	1	although	although	SCONJ
admet-661	74	2	not	not	PART
admet-661	74	3	many	many	ADJ
admet-661	74	4	studies	study	NOUN
admet-661	74	5	on	on	ADP
admet-661	74	6	ph	ph	PROPN
admet-661	74	7	versus	versus	ADP
admet-661	74	8	solubility	solubility	NOUN
admet-661	74	9	of	of	ADP
admet-661	74	10	cocrystals	cocrystal	NOUN
admet-661	74	11	have	have	AUX
admet-661	74	12	been	be	AUX
admet-661	74	13	reported	report	VERB
admet-661	74	14	in	in	ADP
admet-661	74	15	the	the	DET
admet-661	74	16	literature	literature	NOUN
admet-661	74	17	,	,	PUNCT
admet-661	74	18	there	there	PRON
admet-661	74	19	are	be	VERB
admet-661	74	20	numerous	numerous	ADJ
admet-661	74	21	reports	report	NOUN
admet-661	74	22	on	on	ADP
admet-661	74	23	the	the	DET
admet-661	74	24	effect	effect	NOUN
admet-661	74	25	of	of	ADP
admet-661	74	26	ph	ph	NOUN
admet-661	74	27	on	on	ADP
admet-661	74	28	solubility	solubility	NOUN
admet-661	74	29	of	of	ADP
admet-661	74	30	acids	acid	NOUN
admet-661	74	31	,	,	PUNCT
admet-661	74	32	bases	basis	NOUN
admet-661	74	33	and	and	CCONJ
admet-661	74	34	their	their	PRON
admet-661	74	35	salt	salt	NOUN
admet-661	74	36	forms	form	NOUN
admet-661	74	37	available	available	ADJ
admet-661	74	38	[	[	PUNCT
admet-661	74	39	29	29	NUM
admet-661	74	40	-	-	SYM
admet-661	74	41	32	32	NUM
admet-661	74	42	]	]	PUNCT
admet-661	74	43	.	.	PUNCT
admet-661	75	1	there	there	PRON
admet-661	75	2	are	be	VERB
admet-661	75	3	also	also	ADV
admet-661	75	4	numerous	numerous	ADJ
admet-661	75	5	reports	report	NOUN
admet-661	75	6	on	on	ADP
admet-661	75	7	higher	high	ADJ
admet-661	75	8	dissolution	dissolution	NOUN
admet-661	75	9	rates	rate	NOUN
admet-661	75	10	of	of	ADP
admet-661	75	11	salts	salt	NOUN
admet-661	75	12	as	as	ADP
admet-661	75	13	compared	compare	VERB
admet-661	75	14	to	to	ADP
admet-661	75	15	their	their	PRON
admet-661	75	16	respective	respective	ADJ
admet-661	75	17	free	free	ADJ
admet-661	75	18	base	base	NOUN
admet-661	75	19	or	or	CCONJ
admet-661	75	20	acid	acid	NOUN
admet-661	75	21	forms	form	NOUN
admet-661	75	22	due	due	ADJ
admet-661	75	23	to	to	ADP
admet-661	75	24	change	change	VERB
admet-661	75	25	in	in	ADP
admet-661	75	26	ph	ph	ADJ
admet-661	75	27	and	and	CCONJ
admet-661	75	28	increased	increase	VERB
admet-661	75	29	drug	drug	NOUN
admet-661	75	30	solubility	solubility	NOUN
admet-661	75	31	in	in	ADP
admet-661	75	32	diffusion	diffusion	NOUN
admet-661	75	33	layers	layer	NOUN
admet-661	75	34	of	of	ADP
admet-661	75	35	solids	solid	NOUN
admet-661	75	36	during	during	ADP
admet-661	75	37	dissolution	dissolution	ADJ
admet-661	75	38	testing	testing	NOUN
admet-661	75	39	[	[	X
admet-661	75	40	29,32,33	29,32,33	NUM
admet-661	75	41	]	]	PUNCT
admet-661	75	42	.	.	PUNCT
admet-661	76	1	it	it	PRON
admet-661	76	2	was	be	AUX
admet-661	76	3	,	,	PUNCT
admet-661	76	4	therefore	therefore	ADV
admet-661	76	5	,	,	PUNCT
admet-661	76	6	of	of	ADP
admet-661	76	7	interest	interest	NOUN
admet-661	76	8	to	to	PART
admet-661	76	9	determine	determine	VERB
admet-661	76	10	whether	whether	SCONJ
admet-661	76	11	cocrystals	cocrystal	NOUN
admet-661	76	12	could	could	AUX
admet-661	76	13	influence	influence	VERB
admet-661	76	14	drug	drug	NOUN
admet-661	76	15	solubility	solubility	NOUN
admet-661	76	16	and	and	CCONJ
admet-661	76	17	dissolution	dissolution	NOUN
admet-661	76	18	rate	rate	NOUN
admet-661	76	19	analogous	analogous	ADJ
admet-661	76	20	to	to	ADP
admet-661	76	21	salts	salt	NOUN
admet-661	76	22	and	and	CCONJ
admet-661	76	23	,	,	PUNCT
admet-661	76	24	if	if	SCONJ
admet-661	76	25	any	any	DET
admet-661	76	26	differences	difference	NOUN
admet-661	76	27	in	in	ADP
admet-661	76	28	performance	performance	NOUN
admet-661	76	29	of	of	ADP
admet-661	76	30	salts	salt	NOUN
admet-661	76	31	and	and	CCONJ
admet-661	76	32	cocrystals	cocrystal	NOUN
admet-661	76	33	existed	exist	VERB
admet-661	76	34	,	,	PUNCT
admet-661	76	35	what	what	PRON
admet-661	76	36	were	be	AUX
admet-661	76	37	those	those	DET
admet-661	76	38	differences	difference	NOUN
admet-661	76	39	.	.	PUNCT
admet-661	77	1	based	base	VERB
admet-661	77	2	on	on	ADP
admet-661	77	3	these	these	DET
admet-661	77	4	considerations	consideration	NOUN
admet-661	77	5	,	,	PUNCT
admet-661	77	6	primary	primary	ADJ
admet-661	77	7	objectives	objective	NOUN
admet-661	77	8	of	of	ADP
admet-661	77	9	the	the	DET
admet-661	77	10	present	present	ADJ
admet-661	77	11	study	study	NOUN
admet-661	77	12	with	with	ADP
admet-661	77	13	ketoconazole	ketoconazole	PROPN
admet-661	77	14	and	and	CCONJ
admet-661	77	15	its	its	PRON
admet-661	77	16	cocrystals	cocrystal	NOUN
admet-661	77	17	were	be	AUX
admet-661	77	18	the	the	DET
admet-661	77	19	following	following	NOUN
admet-661	77	20	:	:	PUNCT
admet-661	77	21	(	(	PUNCT
admet-661	77	22	a	a	X
admet-661	77	23	)	)	PUNCT
admet-661	77	24	determine	determine	VERB
admet-661	77	25	equilibrium	equilibrium	NOUN
admet-661	77	26	solubility	solubility	NOUN
admet-661	77	27	of	of	ADP
admet-661	77	28	free	free	ADJ
admet-661	77	29	base	base	NOUN
admet-661	77	30	and	and	CCONJ
admet-661	77	31	cocrystals	cocrystal	NOUN
admet-661	77	32	as	as	ADP
admet-661	77	33	functions	function	NOUN
admet-661	77	34	of	of	ADP
admet-661	77	35	ph	ph	NOUN
admet-661	77	36	to	to	PART
admet-661	77	37	ascertain	ascertain	VERB
admet-661	77	38	what	what	PRON
admet-661	77	39	differences	difference	NOUN
admet-661	77	40	exist	exist	VERB
admet-661	77	41	between	between	ADP
admet-661	77	42	the	the	DET
admet-661	77	43	solubility	solubility	NOUN
admet-661	77	44	of	of	ADP
admet-661	77	45	two	two	NUM
admet-661	77	46	forms	form	NOUN
admet-661	77	47	,	,	PUNCT
admet-661	77	48	(	(	PUNCT
admet-661	77	49	b	b	X
admet-661	77	50	)	)	PUNCT
admet-661	77	51	determine	determine	VERB
admet-661	77	52	solid	solid	ADJ
admet-661	77	53	phases	phase	NOUN
admet-661	77	54	in	in	ADP
admet-661	77	55	equilibria	equilibrium	NOUN
admet-661	77	56	with	with	ADP
admet-661	77	57	solutions	solution	NOUN
admet-661	77	58	to	to	PART
admet-661	77	59	study	study	VERB
admet-661	77	60	whether	whether	SCONJ
admet-661	77	61	any	any	DET
admet-661	77	62	conversion	conversion	NOUN
admet-661	77	63	from	from	ADP
admet-661	77	64	cocrystal	cocrystal	ADJ
admet-661	77	65	to	to	PART
admet-661	77	66	free	free	VERB
admet-661	77	67	base	base	NOUN
admet-661	77	68	or	or	CCONJ
admet-661	77	69	vice	vice	NOUN
admet-661	77	70	versa	versa	ADV
admet-661	77	71	occur	occur	VERB
admet-661	77	72	during	during	ADP
admet-661	77	73	solubility	solubility	NOUN
admet-661	77	74	vs.	vs.	ADP
admet-661	77	75	ph	ph	NOUN
admet-661	77	76	determination	determination	NOUN
admet-661	77	77	,	,	PUNCT
admet-661	77	78	(	(	PUNCT
admet-661	77	79	c	c	X
admet-661	77	80	)	)	PUNCT
admet-661	77	81	determine	determine	VERB
admet-661	77	82	possible	possible	ADJ
admet-661	77	83	similarity	similarity	NOUN
admet-661	77	84	and	and	CCONJ
admet-661	77	85	dissimilarity	dissimilarity	NOUN
admet-661	77	86	between	between	ADP
admet-661	77	87	ph	ph	PROPN
admet-661	77	88	vs.	vs.	ADP
admet-661	77	89	solubility	solubility	NOUN
admet-661	77	90	of	of	ADP
admet-661	77	91	cocrystal	cocrystal	NOUN
admet-661	77	92	with	with	ADP
admet-661	77	93	ph	ph	ADJ
admet-661	77	94	-	-	PUNCT
admet-661	77	95	solubility	solubility	NOUN
admet-661	77	96	profiles	profile	NOUN
admet-661	77	97	of	of	ADP
admet-661	77	98	salts	salt	NOUN
admet-661	77	99	reported	report	VERB
admet-661	77	100	in	in	ADP
admet-661	77	101	the	the	DET
admet-661	77	102	literature	literature	NOUN
admet-661	77	103	and	and	CCONJ
admet-661	77	104	,	,	PUNCT
admet-661	77	105	in	in	ADP
admet-661	77	106	particular	particular	ADJ
admet-661	77	107	,	,	PUNCT
admet-661	77	108	whether	whether	SCONJ
admet-661	77	109	any	any	DET
admet-661	77	110	phmax	phmax	NOUN
admet-661	77	111	(	(	PUNCT
admet-661	77	112	ph	ph	NOUN
admet-661	77	113	of	of	ADP
admet-661	77	114	maximum	maximum	ADJ
admet-661	77	115	solubility	solubility	NOUN
admet-661	77	116	)	)	PUNCT
admet-661	77	117	exists	exist	VERB
admet-661	77	118	during	during	ADP
admet-661	77	119	the	the	DET
admet-661	77	120	interconversion	interconversion	NOUN
admet-661	77	121	of	of	ADP
admet-661	77	122	cocrystal	cocrystal	ADJ
admet-661	77	123	and	and	CCONJ
admet-661	77	124	free	free	ADJ
admet-661	77	125	base	base	NOUN
admet-661	77	126	like	like	ADP
admet-661	77	127	that	that	PRON
admet-661	77	128	with	with	ADP
admet-661	77	129	salts	salt	NOUN
admet-661	77	130	,	,	PUNCT
admet-661	77	131	and	and	CCONJ
admet-661	77	132	(	(	PUNCT
admet-661	77	133	d	d	X
admet-661	77	134	)	)	PUNCT
admet-661	77	135	determine	determine	VERB
admet-661	77	136	comparative	comparative	ADJ
admet-661	77	137	intrinsic	intrinsic	ADJ
admet-661	77	138	dissolution	dissolution	NOUN
admet-661	77	139	rates	rate	NOUN
admet-661	77	140	of	of	ADP
admet-661	77	141	cocrystals	cocrystal	NOUN
admet-661	77	142	and	and	CCONJ
admet-661	77	143	the	the	DET
admet-661	77	144	free	free	ADJ
admet-661	77	145	base	base	NOUN
admet-661	77	146	at	at	ADP
admet-661	77	147	different	different	ADJ
admet-661	77	148	ph	ph	ADJ
admet-661	77	149	conditions	condition	NOUN
admet-661	77	150	to	to	PART
admet-661	77	151	ascertain	ascertain	VERB
admet-661	77	152	what	what	PRON
admet-661	77	153	role	role	NOUN
admet-661	77	154	cocrystal	cocrystal	ADJ
admet-661	77	155	formation	formation	NOUN
admet-661	77	156	plays	play	VERB
admet-661	77	157	in	in	ADP
admet-661	77	158	dissolution	dissolution	NOUN
admet-661	77	159	and	and	CCONJ
admet-661	77	160	whether	whether	SCONJ
admet-661	77	161	there	there	PRON
admet-661	77	162	are	be	VERB
admet-661	77	163	any	any	DET
admet-661	77	164	impacts	impact	NOUN
admet-661	77	165	of	of	ADP
admet-661	77	166	microenvironmental	microenvironmental	ADJ
admet-661	77	167	ph	ph	NOUN
admet-661	77	168	at	at	ADP
admet-661	77	169	the	the	DET
admet-661	77	170	dissolving	dissolve	VERB
admet-661	77	171	solid	solid	ADJ
admet-661	77	172	surface	surface	NOUN
admet-661	77	173	on	on	ADP
admet-661	77	174	the	the	DET
admet-661	77	175	dissolution	dissolution	NOUN
admet-661	77	176	rate	rate	NOUN
admet-661	77	177	.	.	PUNCT
admet-661	78	1	experimental	experimental	ADJ
admet-661	78	2	materials	material	NOUN
admet-661	78	3	ketoconazole	ketoconazole	NOUN
admet-661	78	4	was	be	AUX
admet-661	78	5	purchased	purchase	VERB
admet-661	78	6	from	from	ADP
admet-661	78	7	alfa	alfa	PROPN
admet-661	78	8	aesar	aesar	PROPN
admet-661	78	9	,	,	PUNCT
admet-661	78	10	a	a	DET
admet-661	78	11	thermo	thermo	NOUN
admet-661	78	12	fisher	fisher	PROPN
admet-661	78	13	scientific	scientific	ADJ
admet-661	78	14	company	company	NOUN
admet-661	78	15	(	(	PUNCT
admet-661	78	16	ward	ward	PROPN
admet-661	78	17	hill	hill	PROPN
admet-661	78	18	,	,	PUNCT
admet-661	78	19	ma	ma	PROPN
admet-661	78	20	,	,	PUNCT
admet-661	78	21	usa	usa	PROPN
admet-661	78	22	)	)	PUNCT
admet-661	78	23	and	and	CCONJ
admet-661	78	24	used	use	VERB
admet-661	78	25	as	as	SCONJ
admet-661	78	26	received	receive	VERB
admet-661	78	27	.	.	PUNCT
admet-661	79	1	succinic	succinic	ADJ
admet-661	79	2	acid	acid	PROPN
admet-661	79	3	and	and	CCONJ
admet-661	79	4	fumaric	fumaric	ADJ
admet-661	79	5	acid	acid	PROPN
admet-661	79	6	were	be	AUX
admet-661	79	7	purchased	purchase	VERB
admet-661	79	8	,	,	PUNCT
admet-661	79	9	respectively	respectively	ADV
admet-661	79	10	,	,	PUNCT
admet-661	79	11	from	from	ADP
admet-661	79	12	vwr	vwr	PROPN
admet-661	79	13	life	life	PROPN
admet-661	79	14	sciences	sciences	PROPN
admet-661	79	15	(	(	PUNCT
admet-661	79	16	radnor	radnor	PROPN
admet-661	79	17	,	,	PUNCT
admet-661	79	18	pa	pa	PROPN
admet-661	79	19	,	,	PUNCT
admet-661	79	20	usa	usa	PROPN
admet-661	79	21	)	)	PUNCT
admet-661	79	22	and	and	CCONJ
admet-661	79	23	fluka	fluka	VERB
admet-661	79	24	analytical	analytical	ADJ
admet-661	79	25	(	(	PUNCT
admet-661	79	26	fisher	fisher	PROPN
admet-661	79	27	scientific	scientific	PROPN
admet-661	79	28	,	,	PUNCT
admet-661	79	29	pittsburg	pittsburg	PROPN
admet-661	79	30	,	,	PUNCT
admet-661	79	31	usa	usa	PROPN
admet-661	79	32	)	)	PUNCT
admet-661	79	33	.	.	PUNCT
admet-661	80	1	all	all	DET
admet-661	80	2	other	other	ADJ
admet-661	80	3	solvents	solvent	NOUN
admet-661	80	4	and	and	CCONJ
admet-661	80	5	reagents	reagent	NOUN
admet-661	80	6	used	use	VERB
admet-661	80	7	in	in	ADP
admet-661	80	8	this	this	DET
admet-661	80	9	investigation	investigation	NOUN
admet-661	80	10	were	be	AUX
admet-661	80	11	of	of	ADP
admet-661	80	12	analytical	analytical	ADJ
admet-661	80	13	grade	grade	NOUN
admet-661	80	14	or	or	CCONJ
admet-661	80	15	better	well	ADJ
admet-661	80	16	.	.	PUNCT
admet-661	81	1	distilled	distil	VERB
admet-661	81	2	water	water	NOUN
admet-661	81	3	was	be	AUX
admet-661	81	4	used	use	VERB
admet-661	81	5	,	,	PUNCT
admet-661	81	6	as	as	ADP
admet-661	81	7	necessary	necessary	ADJ
admet-661	81	8	,	,	PUNCT
admet-661	81	9	for	for	ADP
admet-661	81	10	all	all	DET
admet-661	81	11	experiments	experiment	NOUN
admet-661	81	12	.	.	PUNCT
admet-661	82	1	vasoya	vasoya	PROPN
admet-661	82	2	et	et	PROPN
admet-661	82	3	al	al	PROPN
admet-661	82	4	.	.	PROPN
admet-661	82	5	admet	admet	PROPN
admet-661	82	6	&	&	CCONJ
admet-661	82	7	dmpk	dmpk	PROPN
admet-661	82	8	7(2	7(2	NUM
admet-661	82	9	)	)	PUNCT
admet-661	82	10	(	(	PUNCT
admet-661	82	11	2019	2019	NUM
admet-661	82	12	)	)	PUNCT
admet-661	82	13	106	106	NUM
admet-661	82	14	-	-	SYM
admet-661	82	15	130	130	NUM
admet-661	82	16	110	110	NUM
admet-661	82	17	preparation	preparation	NOUN
admet-661	82	18	of	of	ADP
admet-661	82	19	ketoconazole	ketoconazole	PROPN
admet-661	82	20	cocrystals	cocrystal	NOUN
admet-661	82	21	cocrystals	cocrystal	NOUN
admet-661	82	22	were	be	AUX
admet-661	82	23	prepared	prepare	VERB
admet-661	82	24	by	by	ADP
admet-661	82	25	modifying	modify	VERB
admet-661	82	26	solvent	solvent	ADJ
admet-661	82	27	evaporation	evaporation	NOUN
admet-661	82	28	methods	method	NOUN
admet-661	82	29	reported	report	VERB
admet-661	82	30	earlier	early	ADV
admet-661	82	31	[	[	X
admet-661	82	32	28	28	NUM
admet-661	82	33	]	]	PUNCT
admet-661	82	34	.	.	PUNCT
admet-661	83	1	in	in	ADP
admet-661	83	2	a	a	DET
admet-661	83	3	typical	typical	ADJ
admet-661	83	4	experiment	experiment	NOUN
admet-661	83	5	for	for	ADP
admet-661	83	6	the	the	DET
admet-661	83	7	preparation	preparation	NOUN
admet-661	83	8	of	of	ADP
admet-661	83	9	ketoconazole	ketoconazole	NOUN
admet-661	83	10	-	-	PUNCT
admet-661	83	11	succinic	succinic	ADJ
admet-661	83	12	acid	acid	NOUN
admet-661	83	13	cocrystal	cocrystal	NOUN
admet-661	83	14	,	,	PUNCT
admet-661	83	15	2	2	NUM
admet-661	83	16	millimoles	millimole	NOUN
admet-661	83	17	of	of	ADP
admet-661	83	18	ketoconazole	ketoconazole	NOUN
admet-661	83	19	(	(	PUNCT
admet-661	83	20	1063	1063	NUM
admet-661	83	21	mg	mg	NUM
admet-661	83	22	)	)	PUNCT
admet-661	83	23	and	and	CCONJ
admet-661	83	24	2.2	2.2	NUM
admet-661	83	25	millimoles	millimole	NOUN
admet-661	83	26	of	of	ADP
admet-661	83	27	succinic	succinic	ADJ
admet-661	83	28	acid	acid	NOUN
admet-661	83	29	(	(	PUNCT
admet-661	83	30	260	260	NUM
admet-661	83	31	mg	mg	NOUN
admet-661	83	32	)	)	PUNCT
admet-661	83	33	were	be	AUX
admet-661	83	34	dissolved	dissolve	VERB
admet-661	83	35	in	in	ADP
admet-661	83	36	4	4	NUM
admet-661	83	37	ml	ml	NOUN
admet-661	83	38	of	of	ADP
admet-661	83	39	3:1	3:1	NUM
admet-661	83	40	v	v	NOUN
admet-661	83	41	/	/	SYM
admet-661	83	42	v	v	NOUN
admet-661	83	43	chloroform	chloroform	NOUN
admet-661	83	44	-	-	PUNCT
admet-661	83	45	methanol	methanol	NOUN
admet-661	83	46	solvent	solvent	NOUN
admet-661	83	47	mixture	mixture	NOUN
admet-661	83	48	by	by	ADP
admet-661	83	49	stirring	stir	VERB
admet-661	83	50	on	on	ADP
admet-661	83	51	a	a	DET
admet-661	83	52	hot	hot	ADJ
admet-661	83	53	plate	plate	NOUN
admet-661	83	54	magnetic	magnetic	ADJ
admet-661	83	55	stirrer	stirrer	NOUN
admet-661	83	56	at	at	ADP
admet-661	83	57	60	60	NUM
admet-661	83	58	-	-	SYM
admet-661	83	59	65	65	NUM
admet-661	83	60	°	°	PROPN
admet-661	83	61	c	c	NOUN
admet-661	83	62	.	.	PUNCT
admet-661	84	1	the	the	DET
admet-661	84	2	solution	solution	NOUN
admet-661	84	3	was	be	AUX
admet-661	84	4	then	then	ADV
admet-661	84	5	kept	keep	VERB
admet-661	84	6	under	under	ADP
admet-661	84	7	vacuum	vacuum	NOUN
admet-661	84	8	for	for	ADP
admet-661	84	9	solvent	solvent	ADJ
admet-661	84	10	evaporation	evaporation	NOUN
admet-661	84	11	and	and	CCONJ
admet-661	84	12	thereby	thereby	ADV
admet-661	84	13	cocrystal	cocrystal	ADJ
admet-661	84	14	precipitation	precipitation	NOUN
admet-661	84	15	.	.	PUNCT
admet-661	85	1	after	after	ADP
admet-661	85	2	complete	complete	ADJ
admet-661	85	3	evaporation	evaporation	NOUN
admet-661	85	4	of	of	ADP
admet-661	85	5	solvent	solvent	NOUN
admet-661	85	6	,	,	PUNCT
admet-661	85	7	the	the	DET
admet-661	85	8	dried	dry	VERB
admet-661	85	9	material	material	NOUN
admet-661	85	10	was	be	AUX
admet-661	85	11	washed	wash	VERB
admet-661	85	12	with	with	ADP
admet-661	85	13	5	5	NUM
admet-661	85	14	ml	ml	NOUN
admet-661	85	15	of	of	ADP
admet-661	85	16	methanol	methanol	NOUN
admet-661	85	17	to	to	PART
admet-661	85	18	remove	remove	VERB
admet-661	85	19	any	any	DET
admet-661	85	20	unconverted	unconverte	VERB
admet-661	85	21	free	free	ADJ
admet-661	85	22	drug	drug	NOUN
admet-661	85	23	and	and	CCONJ
admet-661	85	24	coformer	coformer	NOUN
admet-661	85	25	.	.	PUNCT
admet-661	86	1	the	the	DET
admet-661	86	2	washed	wash	VERB
admet-661	86	3	cocrystals	cocrystal	NOUN
admet-661	86	4	were	be	AUX
admet-661	86	5	dried	dry	VERB
admet-661	86	6	in	in	ADP
admet-661	86	7	a	a	DET
admet-661	86	8	vacuum	vacuum	NOUN
admet-661	86	9	oven	oven	NOUN
admet-661	86	10	at	at	ADP
admet-661	86	11	50	50	NUM
admet-661	86	12	°	°	NOUN
admet-661	86	13	c	c	NOUN
admet-661	86	14	to	to	PART
admet-661	86	15	remove	remove	VERB
admet-661	86	16	any	any	DET
admet-661	86	17	residual	residual	ADJ
admet-661	86	18	methanol	methanol	NOUN
admet-661	86	19	.	.	PUNCT
admet-661	87	1	dried	dry	VERB
admet-661	87	2	cocrystals	cocrystal	NOUN
admet-661	87	3	were	be	AUX
admet-661	87	4	analyzed	analyze	VERB
admet-661	87	5	using	use	VERB
admet-661	87	6	differential	differential	NOUN
admet-661	87	7	scanning	scan	VERB
admet-661	87	8	calorimetry	calorimetry	NOUN
admet-661	87	9	(	(	PUNCT
admet-661	87	10	dsc	dsc	NOUN
admet-661	87	11	)	)	PUNCT
admet-661	87	12	,	,	PUNCT
admet-661	87	13	powder	powder	NOUN
admet-661	87	14	x	x	NOUN
admet-661	87	15	-	-	NOUN
admet-661	87	16	ray	ray	NOUN
admet-661	87	17	diffraction	diffraction	NOUN
admet-661	87	18	(	(	PUNCT
admet-661	87	19	pxrd	pxrd	PROPN
admet-661	87	20	)	)	PUNCT
admet-661	87	21	and	and	CCONJ
admet-661	87	22	raman	raman	NOUN
admet-661	87	23	spectroscopy	spectroscopy	NOUN
admet-661	87	24	.	.	PUNCT
admet-661	88	1	the	the	DET
admet-661	88	2	purity	purity	NOUN
admet-661	88	3	of	of	ADP
admet-661	88	4	cocrystals	cocrystal	NOUN
admet-661	88	5	or	or	CCONJ
admet-661	88	6	the	the	DET
admet-661	88	7	presence	presence	NOUN
admet-661	88	8	of	of	ADP
admet-661	88	9	any	any	DET
admet-661	88	10	unconverted	unconverte	VERB
admet-661	88	11	ketoconazole	ketoconazole	NOUN
admet-661	88	12	or	or	CCONJ
admet-661	88	13	succinic	succinic	ADJ
admet-661	88	14	acid	acid	NOUN
admet-661	88	15	with	with	ADP
admet-661	88	16	cocrystals	cocrystal	NOUN
admet-661	88	17	were	be	AUX
admet-661	88	18	assessed	assess	VERB
admet-661	88	19	by	by	ADP
admet-661	88	20	dsc	dsc	PROPN
admet-661	88	21	,	,	PUNCT
admet-661	88	22	pxrd	pxrd	NOUN
admet-661	88	23	and	and	CCONJ
admet-661	88	24	raman	raman	NOUN
admet-661	88	25	spectroscopy	spectroscopy	NOUN
admet-661	88	26	patterns	pattern	NOUN
admet-661	88	27	.	.	PUNCT
admet-661	89	1	a	a	DET
admet-661	89	2	similar	similar	ADJ
admet-661	89	3	method	method	NOUN
admet-661	89	4	was	be	AUX
admet-661	89	5	also	also	ADV
admet-661	89	6	used	use	VERB
admet-661	89	7	for	for	ADP
admet-661	89	8	the	the	DET
admet-661	89	9	preparation	preparation	NOUN
admet-661	89	10	of	of	ADP
admet-661	89	11	ketoconazole	ketoconazole	NOUN
admet-661	89	12	-	-	PUNCT
admet-661	89	13	fumaric	fumaric	ADJ
admet-661	89	14	acid	acid	PROPN
admet-661	89	15	cocrystal	cocrystal	NOUN
admet-661	89	16	where	where	SCONJ
admet-661	89	17	2	2	NUM
admet-661	89	18	millimoles	millimole	NOUN
admet-661	89	19	of	of	ADP
admet-661	89	20	ketoconazole	ketoconazole	NOUN
admet-661	89	21	(	(	PUNCT
admet-661	89	22	1063	1063	NUM
admet-661	89	23	mg	mg	NUM
admet-661	89	24	)	)	PUNCT
admet-661	89	25	and	and	CCONJ
admet-661	89	26	2.2	2.2	NUM
admet-661	89	27	millimoles	millimole	NOUN
admet-661	89	28	of	of	ADP
admet-661	89	29	fumaric	fumaric	ADJ
admet-661	89	30	acid	acid	PROPN
admet-661	89	31	(	(	PUNCT
admet-661	89	32	255.4	255.4	NUM
admet-661	89	33	mg	mg	NOUN
admet-661	89	34	)	)	PUNCT
admet-661	89	35	were	be	AUX
admet-661	89	36	dissolved	dissolve	VERB
admet-661	89	37	in	in	ADP
admet-661	89	38	5	5	NUM
admet-661	89	39	ml	ml	NOUN
admet-661	89	40	of	of	ADP
admet-661	89	41	3:2	3:2	NUM
admet-661	89	42	v	v	NOUN
admet-661	89	43	/	/	SYM
admet-661	89	44	v	v	NOUN
admet-661	89	45	chloroformmethanol	chloroformmethanol	NOUN
admet-661	89	46	mixture	mixture	NOUN
admet-661	89	47	.	.	PUNCT
admet-661	90	1	multiple	multiple	ADJ
admet-661	90	2	batches	batch	NOUN
admet-661	90	3	of	of	ADP
admet-661	90	4	the	the	DET
admet-661	90	5	two	two	NUM
admet-661	90	6	cocrystals	cocrystal	NOUN
admet-661	90	7	were	be	AUX
admet-661	90	8	prepared	prepare	VERB
admet-661	90	9	for	for	ADP
admet-661	90	10	use	use	NOUN
admet-661	90	11	in	in	ADP
admet-661	90	12	the	the	DET
admet-661	90	13	course	course	NOUN
admet-661	90	14	of	of	ADP
admet-661	90	15	the	the	DET
admet-661	90	16	present	present	ADJ
admet-661	90	17	investigation	investigation	NOUN
admet-661	90	18	and	and	CCONJ
admet-661	90	19	the	the	DET
admet-661	90	20	quality	quality	NOUN
admet-661	90	21	of	of	ADP
admet-661	90	22	materials	material	NOUN
admet-661	90	23	was	be	AUX
admet-661	90	24	found	find	VERB
admet-661	90	25	to	to	PART
admet-661	90	26	be	be	AUX
admet-661	90	27	consistently	consistently	ADV
admet-661	90	28	similar	similar	ADJ
admet-661	90	29	.	.	PUNCT
admet-661	91	1	differential	differential	ADJ
admet-661	91	2	scanning	scan	VERB
admet-661	91	3	calorimetry	calorimetry	NOUN
admet-661	91	4	(	(	PUNCT
admet-661	91	5	dsc	dsc	NOUN
admet-661	91	6	)	)	PUNCT
admet-661	91	7	the	the	DET
admet-661	91	8	dsc	dsc	NOUN
admet-661	91	9	scans	scan	NOUN
admet-661	91	10	were	be	AUX
admet-661	91	11	recorded	record	VERB
admet-661	91	12	using	use	VERB
admet-661	91	13	the	the	DET
admet-661	91	14	q200	q200	PROPN
admet-661	91	15	differential	differential	NOUN
admet-661	91	16	scanning	scanning	NOUN
admet-661	91	17	calorimeter	calorimeter	NOUN
admet-661	91	18	(	(	PUNCT
admet-661	91	19	ta	ta	PROPN
admet-661	91	20	instruments	instrument	NOUN
admet-661	91	21	,	,	PUNCT
admet-661	91	22	wilmington	wilmington	PROPN
admet-661	91	23	,	,	PUNCT
admet-661	91	24	de	de	PROPN
admet-661	91	25	,	,	PUNCT
admet-661	91	26	usa	usa	PROPN
admet-661	91	27	)	)	PUNCT
admet-661	91	28	.	.	PUNCT
admet-661	92	1	accurately	accurately	ADV
admet-661	92	2	weighed	weigh	VERB
admet-661	92	3	samples	sample	NOUN
admet-661	92	4	(	(	PUNCT
admet-661	92	5	4	4	NUM
admet-661	92	6	-	-	SYM
admet-661	92	7	6	6	NUM
admet-661	92	8	mg	mg	NOUN
admet-661	92	9	each	each	PRON
admet-661	92	10	)	)	PUNCT
admet-661	92	11	were	be	AUX
admet-661	92	12	taken	take	VERB
admet-661	92	13	into	into	ADP
admet-661	92	14	tzero	tzero	NOUN
admet-661	92	15	aluminum	aluminum	NOUN
admet-661	92	16	pans	pan	NOUN
admet-661	92	17	and	and	CCONJ
admet-661	92	18	sealed	seal	VERB
admet-661	92	19	with	with	ADP
admet-661	92	20	hermetic	hermetic	ADJ
admet-661	92	21	lids	lid	NOUN
admet-661	92	22	with	with	ADP
admet-661	92	23	pin	pin	NOUN
admet-661	92	24	holes	hole	NOUN
admet-661	92	25	.	.	PUNCT
admet-661	93	1	samples	sample	NOUN
admet-661	93	2	were	be	AUX
admet-661	93	3	heated	heat	VERB
admet-661	93	4	at	at	ADP
admet-661	93	5	the	the	DET
admet-661	93	6	rate	rate	NOUN
admet-661	93	7	of	of	ADP
admet-661	93	8	10	10	NUM
admet-661	93	9	°	°	NOUN
admet-661	93	10	c	c	NOUN
admet-661	93	11	/	/	SYM
admet-661	93	12	min	min	NOUN
admet-661	93	13	from	from	ADP
admet-661	93	14	5	5	NUM
admet-661	93	15	°	°	ADP
admet-661	93	16	c	c	NOUN
admet-661	93	17	to	to	ADP
admet-661	93	18	350	350	NUM
admet-661	93	19	°	°	NOUN
admet-661	93	20	c	c	NOUN
admet-661	93	21	under	under	ADP
admet-661	93	22	nitrogen	nitrogen	NOUN
admet-661	93	23	flush	flush	NOUN
admet-661	93	24	at	at	ADP
admet-661	93	25	the	the	DET
admet-661	93	26	rate	rate	NOUN
admet-661	93	27	of	of	ADP
admet-661	93	28	50	50	NUM
admet-661	93	29	ml	ml	NOUN
admet-661	93	30	/	/	SYM
admet-661	93	31	min	min	NOUN
admet-661	93	32	.	.	PROPN
admet-661	93	33	data	datum	NOUN
admet-661	93	34	acquisition	acquisition	NOUN
admet-661	93	35	was	be	AUX
admet-661	93	36	performed	perform	VERB
admet-661	93	37	using	use	VERB
admet-661	93	38	ta	ta	ADP
admet-661	93	39	analysis	analysis	NOUN
admet-661	93	40	software	software	NOUN
admet-661	93	41	.	.	PUNCT
admet-661	94	1	powder	powder	NOUN
admet-661	94	2	x	x	PROPN
admet-661	94	3	-	-	NOUN
admet-661	94	4	ray	ray	NOUN
admet-661	94	5	diffraction	diffraction	NOUN
admet-661	94	6	(	(	PUNCT
admet-661	94	7	pxrd	pxrd	NOUN
admet-661	94	8	)	)	PUNCT
admet-661	94	9	powder	powder	NOUN
admet-661	94	10	x	x	NOUN
admet-661	94	11	-	-	NOUN
admet-661	94	12	ray	ray	NOUN
admet-661	94	13	diffraction	diffraction	NOUN
admet-661	94	14	analysis	analysis	NOUN
admet-661	94	15	was	be	AUX
admet-661	94	16	conducted	conduct	VERB
admet-661	94	17	using	use	VERB
admet-661	94	18	shimadzu	shimadzu	ADJ
admet-661	94	19	xrd-6000	xrd-6000	NOUN
admet-661	94	20	diffractometer	diffractometer	NOUN
admet-661	94	21	(	(	PUNCT
admet-661	94	22	shimadzu	shimadzu	PROPN
admet-661	94	23	,	,	PUNCT
admet-661	94	24	kyoto	kyoto	PROPN
admet-661	94	25	,	,	PUNCT
admet-661	94	26	japan	japan	PROPN
admet-661	94	27	)	)	PUNCT
admet-661	94	28	,	,	PUNCT
admet-661	94	29	equipped	equip	VERB
admet-661	94	30	with	with	ADP
admet-661	94	31	ni	ni	PROPN
admet-661	94	32	filter	filter	NOUN
admet-661	94	33	and	and	CCONJ
admet-661	94	34	monochromatic	monochromatic	PROPN
admet-661	94	35	cu	cu	PROPN
admet-661	94	36	-	-	PUNCT
admet-661	94	37	ka	ka	PROPN
admet-661	94	38	radiation	radiation	NOUN
admet-661	94	39	source	source	NOUN
admet-661	94	40	.	.	PUNCT
admet-661	95	1	the	the	DET
admet-661	95	2	diffractometer	diffractometer	NOUN
admet-661	95	3	was	be	AUX
admet-661	95	4	operated	operate	VERB
admet-661	95	5	with	with	ADP
admet-661	95	6	a	a	DET
admet-661	95	7	copper	copper	NOUN
admet-661	95	8	anode	anode	NOUN
admet-661	95	9	tube	tube	NOUN
admet-661	95	10	at	at	ADP
admet-661	95	11	the	the	DET
admet-661	95	12	generator	generator	NOUN
admet-661	95	13	voltage	voltage	NOUN
admet-661	95	14	and	and	CCONJ
admet-661	95	15	the	the	DET
admet-661	95	16	current	current	NOUN
admet-661	95	17	of	of	ADP
admet-661	95	18	40	40	NUM
admet-661	95	19	kv	kv	PROPN
admet-661	95	20	and	and	CCONJ
admet-661	95	21	30	30	NUM
admet-661	95	22	ma	ma	PROPN
admet-661	95	23	,	,	PUNCT
admet-661	95	24	respectively	respectively	ADV
admet-661	95	25	.	.	PUNCT
admet-661	96	1	x	x	X
admet-661	96	2	-	-	PUNCT
admet-661	96	3	ray	ray	NOUN
admet-661	96	4	patterns	pattern	NOUN
admet-661	96	5	of	of	ADP
admet-661	96	6	all	all	DET
admet-661	96	7	solid	solid	ADJ
admet-661	96	8	samples	sample	NOUN
admet-661	96	9	were	be	AUX
admet-661	96	10	recorded	record	VERB
admet-661	96	11	between	between	ADP
admet-661	96	12	5	5	NUM
admet-661	96	13	°	°	NOUN
admet-661	96	14	to	to	ADP
admet-661	96	15	50	50	NUM
admet-661	96	16	°	°	NUM
admet-661	96	17	two	two	NUM
admet-661	96	18	-	-	PUNCT
admet-661	96	19	theta	theta	NOUN
admet-661	96	20	angles	angle	NOUN
admet-661	96	21	at	at	ADP
admet-661	96	22	the	the	DET
admet-661	96	23	rate	rate	NOUN
admet-661	96	24	of	of	ADP
admet-661	96	25	2	2	NUM
admet-661	96	26	°	°	NOUN
admet-661	96	27	per	per	ADP
admet-661	96	28	minute	minute	NOUN
admet-661	96	29	.	.	PUNCT
admet-661	97	1	all	all	DET
admet-661	97	2	pxrd	pxrd	NOUN
admet-661	97	3	patterns	pattern	NOUN
admet-661	97	4	were	be	AUX
admet-661	97	5	analyzed	analyze	VERB
admet-661	97	6	for	for	ADP
admet-661	97	7	characteristic	characteristic	ADJ
admet-661	97	8	peaks	peak	NOUN
admet-661	97	9	of	of	ADP
admet-661	97	10	ketoconazole	ketoconazole	NOUN
admet-661	97	11	and	and	CCONJ
admet-661	97	12	its	its	PRON
admet-661	97	13	cocrystals	cocrystal	NOUN
admet-661	97	14	.	.	PUNCT
admet-661	98	1	raman	raman	NOUN
admet-661	98	2	spectroscopy	spectroscopy	VERB
admet-661	98	3	solid	solid	ADJ
admet-661	98	4	samples	sample	NOUN
admet-661	98	5	as	as	ADV
admet-661	98	6	well	well	ADV
admet-661	98	7	as	as	ADP
admet-661	98	8	the	the	DET
admet-661	98	9	excess	excess	ADJ
admet-661	98	10	solids	solid	NOUN
admet-661	98	11	present	present	ADJ
admet-661	98	12	in	in	ADP
admet-661	98	13	suspensions	suspension	NOUN
admet-661	98	14	during	during	ADP
admet-661	98	15	the	the	DET
admet-661	98	16	determination	determination	NOUN
admet-661	98	17	of	of	ADP
admet-661	98	18	aqueous	aqueous	ADJ
admet-661	98	19	solubility	solubility	NOUN
admet-661	98	20	were	be	AUX
admet-661	98	21	analyzed	analyze	VERB
admet-661	98	22	by	by	ADP
admet-661	98	23	raman	raman	NOUN
admet-661	98	24	spectroscopy	spectroscopy	NOUN
admet-661	98	25	.	.	PUNCT
admet-661	99	1	raman	raman	NOUN
admet-661	99	2	spectra	spectra	NOUN
admet-661	99	3	were	be	AUX
admet-661	99	4	generated	generate	VERB
admet-661	99	5	with	with	ADP
admet-661	99	6	the	the	DET
admet-661	99	7	rxn1	rxn1	ADJ
admet-661	99	8	system	system	NOUN
admet-661	99	9	(	(	PUNCT
admet-661	99	10	kaiser	kaiser	PROPN
admet-661	99	11	optics	optics	PROPN
admet-661	99	12	,	,	PUNCT
admet-661	99	13	ann	ann	PROPN
admet-661	99	14	arbor	arbor	PROPN
admet-661	99	15	,	,	PUNCT
admet-661	99	16	mi	mi	PROPN
admet-661	99	17	,	,	PUNCT
admet-661	99	18	usa	usa	PROPN
admet-661	99	19	)	)	PUNCT
admet-661	99	20	using	use	VERB
admet-661	99	21	fiber	fiber	NOUN
admet-661	99	22	optic	optic	NOUN
admet-661	99	23	probe	probe	NOUN
admet-661	99	24	emitting	emit	VERB
admet-661	99	25	785	785	NUM
admet-661	99	26	nm	nm	NOUN
admet-661	99	27	laser	laser	NOUN
admet-661	99	28	with	with	ADP
admet-661	99	29	the	the	DET
admet-661	99	30	total	total	ADJ
admet-661	99	31	power	power	NOUN
admet-661	99	32	of	of	ADP
admet-661	99	33	400	400	NUM
admet-661	99	34	mw	mw	NOUN
admet-661	99	35	.	.	PROPN
admet-661	99	36	data	datum	NOUN
admet-661	99	37	acquisition	acquisition	NOUN
admet-661	99	38	was	be	AUX
admet-661	99	39	performed	perform	VERB
admet-661	99	40	using	use	VERB
admet-661	99	41	ic	ic	PROPN
admet-661	99	42	raman	raman	VERB
admet-661	99	43	4.1	4.1	NUM
admet-661	99	44	software	software	NOUN
admet-661	99	45	from	from	ADP
admet-661	99	46	mettler	mettler	PROPN
admet-661	99	47	toledo	toledo	PROPN
admet-661	99	48	(	(	PUNCT
admet-661	99	49	columbus	columbus	PROPN
admet-661	99	50	,	,	PUNCT
admet-661	99	51	oh	oh	INTJ
admet-661	99	52	,	,	PUNCT
admet-661	99	53	usa	usa	PROPN
admet-661	99	54	)	)	PUNCT
admet-661	99	55	.	.	PUNCT
admet-661	100	1	for	for	ADP
admet-661	100	2	in	in	ADP
admet-661	100	3	situ	situ	ADJ
admet-661	100	4	analysis	analysis	NOUN
admet-661	100	5	of	of	ADP
admet-661	100	6	solids	solid	NOUN
admet-661	100	7	suspended	suspend	VERB
admet-661	100	8	in	in	ADP
admet-661	100	9	aqueous	aqueous	ADJ
admet-661	100	10	media	medium	NOUN
admet-661	100	11	,	,	PUNCT
admet-661	100	12	aliquots	aliquot	NOUN
admet-661	100	13	of	of	ADP
admet-661	100	14	suspensions	suspension	NOUN
admet-661	100	15	were	be	AUX
admet-661	100	16	transferred	transfer	VERB
admet-661	100	17	into	into	ADP
admet-661	100	18	small	small	ADJ
admet-661	100	19	aluminum	aluminum	NOUN
admet-661	100	20	cups	cup	NOUN
admet-661	100	21	and	and	CCONJ
admet-661	100	22	then	then	ADV
admet-661	100	23	exposed	expose	VERB
admet-661	100	24	to	to	ADP
admet-661	100	25	laser	laser	NOUN
admet-661	100	26	beam	beam	NOUN
admet-661	100	27	through	through	ADP
admet-661	100	28	non	non	ADJ
admet-661	100	29	-	-	ADJ
admet-661	100	30	contact	contact	ADJ
admet-661	100	31	raman	raman	NOUN
admet-661	100	32	phat	phat	NOUN
admet-661	100	33	probe	probe	NOUN
admet-661	100	34	(	(	PUNCT
admet-661	100	35	kaiser	kaiser	NOUN
admet-661	100	36	optics	optics	PROPN
admet-661	100	37	)	)	PUNCT
admet-661	100	38	in	in	ADP
admet-661	100	39	dark	dark	ADJ
admet-661	100	40	.	.	PUNCT
admet-661	101	1	after	after	ADP
admet-661	101	2	acquisition	acquisition	NOUN
admet-661	101	3	of	of	ADP
admet-661	101	4	the	the	DET
admet-661	101	5	spectrum	spectrum	NOUN
admet-661	101	6	,	,	PUNCT
admet-661	101	7	the	the	DET
admet-661	101	8	sample	sample	NOUN
admet-661	101	9	was	be	AUX
admet-661	101	10	poured	pour	VERB
admet-661	101	11	back	back	ADV
admet-661	101	12	into	into	ADP
admet-661	101	13	the	the	DET
admet-661	101	14	vial	vial	NOUN
admet-661	101	15	and	and	CCONJ
admet-661	101	16	the	the	DET
admet-661	101	17	shaking	shaking	NOUN
admet-661	101	18	was	be	AUX
admet-661	101	19	continued	continue	VERB
admet-661	101	20	.	.	PUNCT
admet-661	102	1	hplc	hplc	NOUN
admet-661	102	2	analysis	analysis	NOUN
admet-661	102	3	drug	drug	NOUN
admet-661	102	4	concentration	concentration	NOUN
admet-661	102	5	was	be	AUX
admet-661	102	6	analyzed	analyze	VERB
admet-661	102	7	by	by	ADP
admet-661	102	8	reverse	reverse	ADJ
admet-661	102	9	phase	phase	NOUN
admet-661	102	10	high	high	ADJ
admet-661	102	11	pressure	pressure	NOUN
admet-661	102	12	liquid	liquid	NOUN
admet-661	102	13	chromatography	chromatography	NOUN
admet-661	102	14	(	(	PUNCT
admet-661	102	15	hplc	hplc	PROPN
admet-661	102	16	)	)	PUNCT
admet-661	102	17	(	(	PUNCT
admet-661	102	18	hp	hp	PROPN
admet-661	102	19	1100	1100	NUM
admet-661	102	20	series	series	NOUN
admet-661	102	21	,	,	PUNCT
admet-661	102	22	agilent	agilent	PROPN
admet-661	102	23	technologies	technologies	PROPN
admet-661	102	24	,	,	PUNCT
admet-661	102	25	wilmington	wilmington	PROPN
admet-661	102	26	,	,	PUNCT
admet-661	102	27	de	de	PROPN
admet-661	102	28	)	)	PUNCT
admet-661	102	29	.	.	PUNCT
admet-661	103	1	the	the	DET
admet-661	103	2	mobile	mobile	ADJ
admet-661	103	3	phase	phase	NOUN
admet-661	103	4	consisted	consist	VERB
admet-661	103	5	of	of	ADP
admet-661	103	6	3:1	3:1	NUM
admet-661	103	7	ratio	ratio	NOUN
admet-661	103	8	of	of	ADP
admet-661	103	9	acetonitrile	acetonitrile	NOUN
admet-661	103	10	:	:	PUNCT
admet-661	103	11	acetate	acetate	NOUN
admet-661	103	12	buffer	buffer	NOUN
admet-661	103	13	,	,	PUNCT
admet-661	103	14	where	where	SCONJ
admet-661	103	15	,	,	PUNCT
admet-661	103	16	for	for	ADP
admet-661	103	17	the	the	DET
admet-661	103	18	preparation	preparation	NOUN
admet-661	103	19	of	of	ADP
admet-661	103	20	acetate	acetate	NOUN
admet-661	103	21	buffer	buffer	NOUN
admet-661	103	22	,	,	PUNCT
admet-661	103	23	0.04	0.04	NUM
admet-661	103	24	m	m	NOUN
admet-661	103	25	sodium	sodium	NOUN
admet-661	103	26	acetate	acetate	NOUN
admet-661	103	27	trihydrate	trihydrate	NOUN
admet-661	103	28	solution	solution	NOUN
admet-661	103	29	was	be	AUX
admet-661	103	30	prepared	prepare	VERB
admet-661	103	31	in	in	ADP
admet-661	103	32	distilled	distil	VERB
admet-661	103	33	water	water	NOUN
admet-661	103	34	,	,	PUNCT
admet-661	103	35	ph	ph	PROPN
admet-661	103	36	was	be	AUX
admet-661	103	37	adjusted	adjust	VERB
admet-661	103	38	to	to	ADP
admet-661	103	39	4.5	4.5	NUM
admet-661	103	40	using	use	VERB
admet-661	103	41	glacial	glacial	ADJ
admet-661	103	42	acetic	acetic	ADJ
admet-661	103	43	acid	acid	NOUN
admet-661	103	44	,	,	PUNCT
admet-661	103	45	and	and	CCONJ
admet-661	103	46	to	to	ADP
admet-661	103	47	1000	1000	NUM
admet-661	103	48	ml	ml	NOUN
admet-661	103	49	of	of	ADP
admet-661	103	50	this	this	DET
admet-661	103	51	solution	solution	NOUN
admet-661	103	52	,	,	PUNCT
admet-661	103	53	admet	admet	PROPN
admet-661	103	54	&	&	CCONJ
admet-661	103	55	dmpk	dmpk	PROPN
admet-661	103	56	7(2	7(2	NUM
admet-661	103	57	)	)	PUNCT
admet-661	103	58	(	(	PUNCT
admet-661	103	59	2019	2019	NUM
admet-661	103	60	)	)	PUNCT
admet-661	103	61	106	106	NUM
admet-661	103	62	-	-	SYM
admet-661	103	63	130	130	NUM
admet-661	103	64	solubility	solubility	NOUN
admet-661	103	65	and	and	CCONJ
admet-661	103	66	dissolution	dissolution	NOUN
admet-661	103	67	of	of	ADP
admet-661	103	68	cocrystals	cocrystal	NOUN
admet-661	103	69	doi	doi	NOUN
admet-661	103	70	:	:	PUNCT
admet-661	103	71	10.5599	10.5599	NUM
admet-661	103	72	/	/	SYM
admet-661	103	73	admet.661	admet.661	PROPN
admet-661	103	74	111	111	NUM
admet-661	103	75	2	2	NUM
admet-661	103	76	ml	ml	NOUN
admet-661	103	77	of	of	ADP
admet-661	103	78	triethyl	triethyl	PROPN
admet-661	103	79	amine	amine	PROPN
admet-661	103	80	was	be	AUX
admet-661	103	81	added	add	VERB
admet-661	103	82	.	.	PUNCT
admet-661	104	1	for	for	ADP
admet-661	104	2	hplc	hplc	NOUN
admet-661	104	3	analysis	analysis	NOUN
admet-661	104	4	,	,	PUNCT
admet-661	104	5	c18	c18	NOUN
admet-661	104	6	column	column	NOUN
admet-661	104	7	(	(	PUNCT
admet-661	104	8	agilent	agilent	PROPN
admet-661	104	9	zorbax	zorbax	PROPN
admet-661	104	10	eclipse	eclipse	VERB
admet-661	104	11	xdb	xdb	PRON
admet-661	104	12	columns	column	NOUN
admet-661	104	13	,	,	PUNCT
admet-661	104	14	agilent	agilent	PROPN
admet-661	104	15	technologies	technologies	PROPN
admet-661	104	16	,	,	PUNCT
admet-661	104	17	santa	santa	PROPN
admet-661	104	18	clara	clara	PROPN
admet-661	104	19	,	,	PUNCT
admet-661	104	20	ca	ca	NOUN
admet-661	104	21	)	)	PUNCT
admet-661	104	22	was	be	AUX
admet-661	104	23	used	use	VERB
admet-661	104	24	with	with	ADP
admet-661	104	25	0.75	0.75	NUM
admet-661	104	26	ml	ml	NOUN
admet-661	104	27	/	/	SYM
admet-661	104	28	min	min	NOUN
admet-661	104	29	flow	flow	NOUN
admet-661	104	30	rate	rate	NOUN
admet-661	104	31	,	,	PUNCT
admet-661	104	32	230	230	NUM
admet-661	104	33	nm	nm	ADJ
admet-661	104	34	wavelength	wavelength	NOUN
admet-661	104	35	,	,	PUNCT
admet-661	104	36	and	and	CCONJ
admet-661	104	37	25	25	NUM
admet-661	104	38	°	°	NOUN
admet-661	104	39	c	c	NOUN
admet-661	104	40	temperature	temperature	NOUN
admet-661	104	41	.	.	PUNCT
admet-661	105	1	determination	determination	NOUN
admet-661	105	2	of	of	ADP
admet-661	105	3	ph	ph	PROPN
admet-661	105	4	vs	vs	ADP
admet-661	105	5	solubility	solubility	NOUN
admet-661	105	6	profiles	profile	NOUN
admet-661	105	7	in	in	ADP
admet-661	105	8	a	a	DET
admet-661	105	9	‘	'	PUNCT
admet-661	105	10	white	white	ADJ
admet-661	105	11	paper	paper	NOUN
admet-661	105	12	’	'	PUNCT
admet-661	105	13	published	publish	VERB
admet-661	105	14	by	by	ADP
admet-661	105	15	an	an	DET
admet-661	105	16	international	international	ADJ
admet-661	105	17	panel	panel	NOUN
admet-661	105	18	of	of	ADP
admet-661	105	19	experts	expert	NOUN
admet-661	105	20	,	,	PUNCT
admet-661	105	21	avdeef	avdeef	NOUN
admet-661	105	22	et	et	PROPN
admet-661	105	23	al	al	PROPN
admet-661	105	24	.	.	PUNCT
admet-661	106	1	[	[	X
admet-661	106	2	34	34	NUM
admet-661	106	3	]	]	PUNCT
admet-661	106	4	reported	report	VERB
admet-661	106	5	that	that	SCONJ
admet-661	106	6	a	a	DET
admet-661	106	7	systematic	systematic	ADJ
admet-661	106	8	determination	determination	NOUN
admet-661	106	9	of	of	ADP
admet-661	106	10	solubility	solubility	NOUN
admet-661	106	11	by	by	ADP
admet-661	106	12	taking	take	VERB
admet-661	106	13	into	into	ADP
admet-661	106	14	consideration	consideration	NOUN
admet-661	106	15	such	such	ADJ
admet-661	106	16	factors	factor	NOUN
admet-661	106	17	as	as	ADP
admet-661	106	18	equilibration	equilibration	NOUN
admet-661	106	19	time	time	NOUN
admet-661	106	20	,	,	PUNCT
admet-661	106	21	stirring	stirring	NOUN
admet-661	106	22	rate	rate	NOUN
admet-661	106	23	,	,	PUNCT
admet-661	106	24	equilibrium	equilibrium	NOUN
admet-661	106	25	ph	ph	NOUN
admet-661	106	26	,	,	PUNCT
admet-661	106	27	temperature	temperature	NOUN
admet-661	106	28	,	,	PUNCT
admet-661	106	29	compositions	composition	NOUN
admet-661	106	30	of	of	ADP
admet-661	106	31	aqueous	aqueous	ADJ
admet-661	106	32	media	medium	NOUN
admet-661	106	33	(	(	PUNCT
admet-661	106	34	buffers	buffer	NOUN
admet-661	106	35	,	,	PUNCT
admet-661	106	36	ionic	ionic	ADJ
admet-661	106	37	strength	strength	NOUN
admet-661	106	38	,	,	PUNCT
admet-661	106	39	etc	etc	X
admet-661	106	40	.	.	X
admet-661	106	41	)	)	PUNCT
admet-661	106	42	,	,	PUNCT
admet-661	106	43	characteristics	characteristic	NOUN
admet-661	106	44	of	of	ADP
admet-661	106	45	solid	solid	ADJ
admet-661	106	46	phase	phase	NOUN
admet-661	106	47	,	,	PUNCT
admet-661	106	48	and	and	CCONJ
admet-661	106	49	so	so	ADV
admet-661	106	50	forth	forth	ADV
admet-661	106	51	,	,	PUNCT
admet-661	106	52	is	be	AUX
admet-661	106	53	critically	critically	ADV
admet-661	106	54	important	important	ADJ
admet-661	106	55	for	for	ADP
admet-661	106	56	accurate	accurate	ADJ
admet-661	106	57	measurement	measurement	NOUN
admet-661	106	58	of	of	ADP
admet-661	106	59	solubility	solubility	NOUN
admet-661	106	60	of	of	ADP
admet-661	106	61	drug	drug	NOUN
admet-661	106	62	substances	substance	NOUN
admet-661	106	63	and	and	CCONJ
admet-661	106	64	especially	especially	ADV
admet-661	106	65	when	when	SCONJ
admet-661	106	66	the	the	DET
admet-661	106	67	drug	drug	NOUN
admet-661	106	68	substances	substance	NOUN
admet-661	106	69	are	be	AUX
admet-661	106	70	ionizable	ionizable	ADJ
admet-661	106	71	.	.	PUNCT
admet-661	107	1	the	the	DET
admet-661	107	2	composition	composition	NOUN
admet-661	107	3	of	of	ADP
admet-661	107	4	solid	solid	ADJ
admet-661	107	5	phases	phase	NOUN
admet-661	107	6	in	in	ADP
admet-661	107	7	equilibria	equilibrium	NOUN
admet-661	107	8	with	with	ADP
admet-661	107	9	aqueous	aqueous	ADJ
admet-661	107	10	media	medium	NOUN
admet-661	107	11	may	may	AUX
admet-661	107	12	also	also	ADV
admet-661	107	13	change	change	VERB
admet-661	107	14	depending	depend	VERB
admet-661	107	15	on	on	ADP
admet-661	107	16	the	the	DET
admet-661	107	17	buffering	buffering	NOUN
admet-661	107	18	agents	agent	NOUN
admet-661	107	19	used	use	VERB
admet-661	107	20	[	[	X
admet-661	107	21	35	35	NUM
admet-661	107	22	]	]	PUNCT
admet-661	107	23	.	.	PUNCT
admet-661	108	1	for	for	ADP
admet-661	108	2	these	these	DET
admet-661	108	3	reasons	reason	NOUN
admet-661	108	4	,	,	PUNCT
admet-661	108	5	we	we	PRON
admet-661	108	6	have	have	AUX
admet-661	108	7	undertaken	undertake	VERB
admet-661	108	8	systematic	systematic	ADJ
admet-661	108	9	determination	determination	NOUN
admet-661	108	10	of	of	ADP
admet-661	108	11	aqueous	aqueous	ADJ
admet-661	108	12	solubility	solubility	NOUN
admet-661	108	13	of	of	ADP
admet-661	108	14	ketoconazole	ketoconazole	NOUN
admet-661	108	15	,	,	PUNCT
admet-661	108	16	an	an	DET
admet-661	108	17	ionizable	ionizable	ADJ
admet-661	108	18	drug	drug	NOUN
admet-661	108	19	,	,	PUNCT
admet-661	108	20	under	under	ADP
admet-661	108	21	different	different	ADJ
admet-661	108	22	experimental	experimental	ADJ
admet-661	108	23	conditions	condition	NOUN
admet-661	108	24	,	,	PUNCT
admet-661	108	25	as	as	SCONJ
admet-661	108	26	described	describe	VERB
admet-661	108	27	below	below	ADV
admet-661	108	28	,	,	PUNCT
admet-661	108	29	by	by	ADP
admet-661	108	30	taking	take	VERB
admet-661	108	31	into	into	ADP
admet-661	108	32	considerations	consideration	NOUN
admet-661	108	33	the	the	DET
admet-661	108	34	recommendations	recommendation	NOUN
admet-661	108	35	made	make	VERB
admet-661	108	36	in	in	ADP
admet-661	108	37	these	these	DET
admet-661	108	38	publications	publication	NOUN
admet-661	108	39	.	.	PUNCT
admet-661	109	1	ketoconazole	ketoconazole	PROPN
admet-661	109	2	solubility	solubility	NOUN
admet-661	109	3	by	by	ADP
admet-661	109	4	ph	ph	ADJ
admet-661	109	5	adjustment	adjustment	NOUN
admet-661	109	6	with	with	ADP
admet-661	109	7	hcl	hcl	PROPN
admet-661	109	8	the	the	DET
admet-661	109	9	ph	ph	VERB
admet-661	109	10	-	-	PUNCT
admet-661	109	11	solubility	solubility	NOUN
admet-661	109	12	profile	profile	NOUN
admet-661	109	13	of	of	ADP
admet-661	109	14	ketoconazole	ketoconazole	NOUN
admet-661	109	15	was	be	AUX
admet-661	109	16	generated	generate	VERB
admet-661	109	17	by	by	ADP
admet-661	109	18	adjusting	adjust	VERB
admet-661	109	19	ph	ph	NOUN
admet-661	109	20	of	of	ADP
admet-661	109	21	its	its	PRON
admet-661	109	22	suspension	suspension	NOUN
admet-661	109	23	in	in	ADP
admet-661	109	24	water	water	NOUN
admet-661	109	25	using	use	VERB
admet-661	109	26	different	different	ADJ
admet-661	109	27	concentrations	concentration	NOUN
admet-661	109	28	of	of	ADP
admet-661	109	29	hcl	hcl	PROPN
admet-661	109	30	solutions	solution	NOUN
admet-661	109	31	(	(	PUNCT
admet-661	109	32	0.001	0.001	NUM
admet-661	109	33	to	to	PART
admet-661	109	34	1	1	NUM
admet-661	109	35	m	m	NOUN
admet-661	109	36	)	)	PUNCT
admet-661	109	37	,	,	PUNCT
admet-661	109	38	as	as	ADP
admet-661	109	39	necessary	necessary	ADJ
admet-661	109	40	,	,	PUNCT
admet-661	109	41	to	to	PART
admet-661	109	42	obtain	obtain	VERB
admet-661	109	43	the	the	DET
admet-661	109	44	desired	desire	VERB
admet-661	109	45	ph	ph	NOUN
admet-661	109	46	.	.	PROPN
admet-661	109	47	in	in	ADP
admet-661	109	48	a	a	DET
admet-661	109	49	typical	typical	ADJ
admet-661	109	50	experiment	experiment	NOUN
admet-661	109	51	,	,	PUNCT
admet-661	109	52	5	5	NUM
admet-661	109	53	ml	ml	NOUN
admet-661	109	54	of	of	ADP
admet-661	109	55	distilled	distil	VERB
admet-661	109	56	water	water	NOUN
admet-661	109	57	was	be	AUX
admet-661	109	58	taken	take	VERB
admet-661	109	59	in	in	ADP
admet-661	109	60	a	a	DET
admet-661	109	61	20	20	NUM
admet-661	109	62	-	-	PUNCT
admet-661	109	63	ml	ml	NOUN
admet-661	109	64	glass	glass	NOUN
admet-661	109	65	vial	vial	NOUN
admet-661	109	66	with	with	ADP
admet-661	109	67	a	a	DET
admet-661	109	68	small	small	ADJ
admet-661	109	69	amount	amount	NOUN
admet-661	109	70	of	of	ADP
admet-661	109	71	ketoconazole	ketoconazole	NOUN
admet-661	109	72	(	(	PUNCT
admet-661	109	73	5	5	NUM
admet-661	109	74	-	-	SYM
admet-661	109	75	10	10	NUM
admet-661	109	76	mg	mg	NUM
admet-661	109	77	)	)	PUNCT
admet-661	109	78	,	,	PUNCT
admet-661	109	79	and	and	CCONJ
admet-661	109	80	the	the	DET
admet-661	109	81	vial	vial	ADJ
admet-661	109	82	was	be	AUX
admet-661	109	83	shaken	shake	VERB
admet-661	109	84	in	in	ADP
admet-661	109	85	a	a	DET
admet-661	109	86	water	water	NOUN
admet-661	109	87	bath	bath	NOUN
admet-661	109	88	shaker	shaker	NOUN
admet-661	109	89	(	(	PUNCT
admet-661	109	90	innova	innova	PROPN
admet-661	109	91	3100	3100	NUM
admet-661	109	92	,	,	PUNCT
admet-661	109	93	new	new	PROPN
admet-661	109	94	brunswick	brunswick	PROPN
admet-661	109	95	scientific	scientific	PROPN
admet-661	109	96	co.	co.	PROPN
admet-661	109	97	,	,	PUNCT
admet-661	109	98	edison	edison	PROPN
admet-661	109	99	,	,	PUNCT
admet-661	109	100	nj	nj	PROPN
admet-661	109	101	)	)	PUNCT
admet-661	109	102	at	at	ADP
admet-661	109	103	25	25	NUM
admet-661	109	104	°	°	NOUN
admet-661	109	105	c	c	NOUN
admet-661	109	106	.	.	PUNCT
admet-661	110	1	multiple	multiple	ADJ
admet-661	110	2	vials	vial	NOUN
admet-661	110	3	were	be	AUX
admet-661	110	4	prepared	prepare	VERB
admet-661	110	5	using	use	VERB
admet-661	110	6	different	different	ADJ
admet-661	110	7	concentration	concentration	NOUN
admet-661	110	8	of	of	ADP
admet-661	110	9	hcl	hcl	PROPN
admet-661	110	10	solutions	solution	NOUN
admet-661	110	11	(	(	PUNCT
admet-661	110	12	0.001	0.001	NUM
admet-661	110	13	m	m	NOUN
admet-661	110	14	to	to	ADP
admet-661	110	15	1	1	NUM
admet-661	110	16	m	m	NOUN
admet-661	110	17	)	)	PUNCT
admet-661	110	18	so	so	SCONJ
admet-661	110	19	that	that	SCONJ
admet-661	110	20	different	different	ADJ
admet-661	110	21	ph	ph	ADJ
admet-661	110	22	values	value	NOUN
admet-661	110	23	could	could	AUX
admet-661	110	24	be	be	AUX
admet-661	110	25	attained	attain	VERB
admet-661	110	26	,	,	PUNCT
admet-661	110	27	and	and	CCONJ
admet-661	110	28	,	,	PUNCT
admet-661	110	29	when	when	SCONJ
admet-661	110	30	needed	need	VERB
admet-661	110	31	,	,	PUNCT
admet-661	110	32	more	more	ADJ
admet-661	110	33	amount	amount	NOUN
admet-661	110	34	of	of	ADP
admet-661	110	35	free	free	ADJ
admet-661	110	36	base	base	NOUN
admet-661	110	37	was	be	AUX
admet-661	110	38	added	add	VERB
admet-661	110	39	to	to	PART
admet-661	110	40	maintain	maintain	VERB
admet-661	110	41	excess	excess	ADJ
admet-661	110	42	solid	solid	ADJ
admet-661	110	43	in	in	ADP
admet-661	110	44	the	the	DET
admet-661	110	45	vials	vial	NOUN
admet-661	110	46	.	.	PUNCT
admet-661	111	1	ketoconazole	ketoconazole	PROPN
admet-661	111	2	solubility	solubility	PROPN
admet-661	111	3	was	be	AUX
admet-661	111	4	measured	measure	VERB
admet-661	111	5	at	at	ADP
admet-661	111	6	enough	enough	ADJ
admet-661	111	7	number	number	NOUN
admet-661	111	8	of	of	ADP
admet-661	111	9	ph	ph	ADJ
admet-661	111	10	points	point	NOUN
admet-661	111	11	by	by	ADP
admet-661	111	12	repeating	repeat	VERB
admet-661	111	13	above	above	ADP
admet-661	111	14	mentioned	mention	VERB
admet-661	111	15	procedure	procedure	NOUN
admet-661	111	16	as	as	ADP
admet-661	111	17	exact	exact	ADJ
admet-661	111	18	replicates	replicate	NOUN
admet-661	111	19	of	of	ADP
admet-661	111	20	ph	ph	ADJ
admet-661	111	21	point	point	NOUN
admet-661	111	22	is	be	AUX
admet-661	111	23	experimentally	experimentally	ADV
admet-661	111	24	difficult	difficult	ADJ
admet-661	111	25	.	.	PUNCT
admet-661	112	1	the	the	DET
admet-661	112	2	ph	ph	NOUN
admet-661	112	3	of	of	ADP
admet-661	112	4	the	the	DET
admet-661	112	5	suspension	suspension	NOUN
admet-661	112	6	was	be	AUX
admet-661	112	7	measured	measure	VERB
admet-661	112	8	at	at	ADP
admet-661	112	9	4	4	NUM
admet-661	112	10	and	and	CCONJ
admet-661	112	11	24	24	NUM
admet-661	112	12	h	h	NOUN
admet-661	112	13	and	and	CCONJ
admet-661	112	14	concentrations	concentration	NOUN
admet-661	112	15	of	of	ADP
admet-661	112	16	ketoconazole	ketoconazole	NOUN
admet-661	112	17	at	at	ADP
admet-661	112	18	these	these	DET
admet-661	112	19	time	time	NOUN
admet-661	112	20	points	point	NOUN
admet-661	112	21	were	be	AUX
admet-661	112	22	determined	determine	VERB
admet-661	112	23	by	by	ADP
admet-661	112	24	filtering	filter	VERB
admet-661	112	25	0.5	0.5	NUM
admet-661	112	26	to	to	PART
admet-661	112	27	1	1	NUM
admet-661	112	28	ml	ml	NOUN
admet-661	112	29	of	of	ADP
admet-661	112	30	aliquots	aliquot	NOUN
admet-661	112	31	through	through	ADP
admet-661	112	32	poly(vinylidene	poly(vinylidene	PROPN
admet-661	112	33	fluoride	fluoride	NOUN
admet-661	112	34	)	)	PUNCT
admet-661	112	35	(	(	PUNCT
admet-661	112	36	pvdf	pvdf	NOUN
admet-661	112	37	)	)	PUNCT
admet-661	112	38	filter	filter	NOUN
admet-661	112	39	with	with	ADP
admet-661	112	40	0.45	0.45	NUM
admet-661	112	41	micron	micron	NOUN
admet-661	112	42	pore	pore	ADJ
admet-661	112	43	size	size	NOUN
admet-661	112	44	and	and	CCONJ
admet-661	112	45	analyzing	analyze	VERB
admet-661	112	46	filtrate	filtrate	NOUN
admet-661	112	47	by	by	ADP
admet-661	112	48	hplc	hplc	NOUN
admet-661	112	49	.	.	PUNCT
admet-661	113	1	additional	additional	ADJ
admet-661	113	2	hcl	hcl	PROPN
admet-661	113	3	solution	solution	NOUN
admet-661	113	4	and	and	CCONJ
admet-661	113	5	excess	excess	ADJ
admet-661	113	6	ketoconazole	ketoconazole	NOUN
admet-661	113	7	were	be	AUX
admet-661	113	8	added	add	VERB
admet-661	113	9	to	to	ADP
admet-661	113	10	the	the	DET
admet-661	113	11	suspension	suspension	NOUN
admet-661	113	12	in	in	ADP
admet-661	113	13	vial	vial	ADJ
admet-661	113	14	and	and	CCONJ
admet-661	113	15	shaken	shake	VERB
admet-661	113	16	for	for	ADP
admet-661	113	17	another	another	DET
admet-661	113	18	ph	ph	NOUN
admet-661	113	19	point	point	NOUN
admet-661	113	20	,	,	PUNCT
admet-661	113	21	and	and	CCONJ
admet-661	113	22	the	the	DET
admet-661	113	23	process	process	NOUN
admet-661	113	24	was	be	AUX
admet-661	113	25	repeated	repeat	VERB
admet-661	113	26	until	until	SCONJ
admet-661	113	27	enough	enough	ADJ
admet-661	113	28	points	point	NOUN
admet-661	113	29	on	on	ADP
admet-661	113	30	the	the	DET
admet-661	113	31	ph	ph	ADJ
admet-661	113	32	scale	scale	NOUN
admet-661	113	33	were	be	AUX
admet-661	113	34	obtained	obtain	VERB
admet-661	113	35	.	.	PUNCT
admet-661	114	1	more	more	ADJ
admet-661	114	2	than	than	ADP
admet-661	114	3	one	one	NUM
admet-661	114	4	suspension	suspension	NOUN
admet-661	114	5	in	in	ADP
admet-661	114	6	different	different	ADJ
admet-661	114	7	vials	vial	NOUN
admet-661	114	8	were	be	AUX
admet-661	114	9	used	use	VERB
admet-661	114	10	to	to	PART
admet-661	114	11	generate	generate	VERB
admet-661	114	12	a	a	DET
admet-661	114	13	complete	complete	ADJ
admet-661	114	14	profile	profile	NOUN
admet-661	114	15	.	.	PUNCT
admet-661	115	1	cocrystal	cocrystal	ADJ
admet-661	115	2	solubility	solubility	NOUN
admet-661	115	3	by	by	ADP
admet-661	115	4	adjusting	adjust	VERB
admet-661	115	5	ph	ph	PROPN
admet-661	115	6	with	with	ADP
admet-661	115	7	coformer	coformer	NOUN
admet-661	115	8	acids	acid	NOUN
admet-661	115	9	and	and	CCONJ
admet-661	115	10	naoh	naoh	PROPN
admet-661	115	11	cocrystal	cocrystal	PROPN
admet-661	115	12	solubility	solubility	PROPN
admet-661	115	13	at	at	ADP
admet-661	115	14	different	different	ADJ
admet-661	115	15	ph	ph	ADJ
admet-661	115	16	values	value	NOUN
admet-661	115	17	was	be	AUX
admet-661	115	18	determined	determine	VERB
admet-661	115	19	using	use	VERB
admet-661	115	20	solutions	solution	NOUN
admet-661	115	21	of	of	ADP
admet-661	115	22	coformer	coformer	PROPN
admet-661	115	23	acid	acid	PROPN
admet-661	115	24	(	(	PUNCT
admet-661	115	25	succinic	succinic	ADJ
admet-661	115	26	acid	acid	NOUN
admet-661	115	27	or	or	CCONJ
admet-661	115	28	fumaric	fumaric	ADJ
admet-661	115	29	acid	acid	NOUN
admet-661	115	30	)	)	PUNCT
admet-661	115	31	to	to	PART
admet-661	115	32	lower	low	ADJ
admet-661	115	33	ph	ph	NOUN
admet-661	115	34	of	of	ADP
admet-661	115	35	aqueous	aqueous	ADJ
admet-661	115	36	suspensions	suspension	NOUN
admet-661	115	37	and	and	CCONJ
admet-661	115	38	by	by	ADP
admet-661	115	39	adding	add	VERB
admet-661	115	40	naoh	naoh	ADJ
admet-661	115	41	solutions	solution	NOUN
admet-661	115	42	to	to	PART
admet-661	115	43	adjust	adjust	VERB
admet-661	115	44	higher	high	ADJ
admet-661	115	45	ph	ph	VERB
admet-661	115	46	.	.	PROPN
admet-661	115	47	excess	excess	ADJ
admet-661	115	48	amount	amount	NOUN
admet-661	115	49	of	of	ADP
admet-661	115	50	cocrystal	cocrystal	NOUN
admet-661	115	51	was	be	AUX
admet-661	115	52	dispersed	disperse	VERB
admet-661	115	53	in	in	ADP
admet-661	115	54	5	5	NUM
admet-661	115	55	ml	ml	NOUN
admet-661	115	56	of	of	ADP
admet-661	115	57	distilled	distil	VERB
admet-661	115	58	water	water	NOUN
admet-661	115	59	in	in	ADP
admet-661	115	60	a	a	DET
admet-661	115	61	20	20	NUM
admet-661	115	62	ml	ml	NOUN
admet-661	115	63	glass	glass	NOUN
admet-661	115	64	vial	vial	NOUN
admet-661	115	65	,	,	PUNCT
admet-661	115	66	and	and	CCONJ
admet-661	115	67	when	when	SCONJ
admet-661	115	68	the	the	DET
admet-661	115	69	cocrystal	cocrystal	ADJ
admet-661	115	70	suspension	suspension	NOUN
admet-661	115	71	reached	reach	VERB
admet-661	115	72	a	a	DET
admet-661	115	73	specific	specific	ADJ
admet-661	115	74	ph	ph	NOUN
admet-661	115	75	after	after	ADP
admet-661	115	76	equilibration	equilibration	NOUN
admet-661	115	77	in	in	ADP
admet-661	115	78	a	a	DET
admet-661	115	79	water	water	NOUN
admet-661	115	80	bath	bath	NOUN
admet-661	115	81	at	at	ADP
admet-661	115	82	25	25	NUM
admet-661	115	83	°	°	NOUN
admet-661	115	84	c	c	NOUN
admet-661	115	85	by	by	ADP
admet-661	115	86	shaking	shake	VERB
admet-661	115	87	,	,	PUNCT
admet-661	115	88	coformer	coformer	NOUN
admet-661	115	89	solutions	solution	NOUN
admet-661	115	90	(	(	PUNCT
admet-661	115	91	4	4	NUM
admet-661	115	92	mg	mg	NUM
admet-661	115	93	/	/	SYM
admet-661	115	94	ml	ml	X
admet-661	115	95	fumaric	fumaric	ADJ
admet-661	115	96	acid	acid	PROPN
admet-661	115	97	or	or	CCONJ
admet-661	115	98	50	50	NUM
admet-661	115	99	mg	mg	NUM
admet-661	115	100	/	/	SYM
admet-661	115	101	ml	ml	NOUN
admet-661	115	102	succinic	succinic	ADJ
admet-661	115	103	acid	acid	NOUN
admet-661	115	104	)	)	PUNCT
admet-661	115	105	were	be	AUX
admet-661	115	106	added	add	VERB
admet-661	115	107	to	to	ADP
admet-661	115	108	respective	respective	ADJ
admet-661	115	109	cocrystal	cocrystal	ADJ
admet-661	115	110	suspensions	suspension	NOUN
admet-661	115	111	to	to	PART
admet-661	115	112	lower	low	ADJ
admet-661	115	113	ph	ph	NOUN
admet-661	115	114	,	,	PUNCT
admet-661	115	115	and	and	CCONJ
admet-661	115	116	the	the	DET
admet-661	115	117	vials	vial	NOUN
admet-661	115	118	were	be	AUX
admet-661	115	119	shaken	shake	VERB
admet-661	115	120	for	for	ADP
admet-661	115	121	additional	additional	ADJ
admet-661	115	122	96	96	NUM
admet-661	115	123	h	h	NOUN
admet-661	115	124	at	at	ADP
admet-661	115	125	25	25	NUM
admet-661	115	126	°	°	NOUN
admet-661	115	127	c	c	NOUN
admet-661	115	128	in	in	ADP
admet-661	115	129	water	water	NOUN
admet-661	115	130	bath	bath	NOUN
admet-661	115	131	.	.	PUNCT
admet-661	116	1	after	after	ADP
admet-661	116	2	equilibration	equilibration	NOUN
admet-661	116	3	,	,	PUNCT
admet-661	116	4	the	the	DET
admet-661	116	5	concentration	concentration	NOUN
admet-661	116	6	of	of	ADP
admet-661	116	7	ketoconazole	ketoconazole	NOUN
admet-661	116	8	at	at	ADP
admet-661	116	9	the	the	DET
admet-661	116	10	attained	attain	VERB
admet-661	116	11	ph	ph	NOUN
admet-661	116	12	was	be	AUX
admet-661	116	13	determined	determine	VERB
admet-661	116	14	by	by	ADP
admet-661	116	15	withdrawing	withdraw	VERB
admet-661	116	16	0.5	0.5	NUM
admet-661	116	17	-	-	SYM
admet-661	116	18	1	1	NUM
admet-661	116	19	ml	ml	NOUN
admet-661	116	20	of	of	ADP
admet-661	116	21	aliquot	aliquot	NOUN
admet-661	116	22	for	for	ADP
admet-661	116	23	filtration	filtration	NOUN
admet-661	116	24	through	through	ADP
admet-661	116	25	0.45	0.45	NUM
admet-661	116	26	micron	micron	NOUN
admet-661	116	27	filter	filter	NOUN
admet-661	116	28	,	,	PUNCT
admet-661	116	29	followed	follow	VERB
admet-661	116	30	by	by	ADP
admet-661	116	31	hplc	hplc	NOUN
admet-661	116	32	analysis	analysis	NOUN
admet-661	116	33	.	.	PUNCT
admet-661	117	1	for	for	ADP
admet-661	117	2	higher	high	ADJ
admet-661	117	3	ph	ph	VERB
admet-661	117	4	,	,	PUNCT
admet-661	117	5	different	different	ADJ
admet-661	117	6	volumes	volume	NOUN
admet-661	117	7	of	of	ADP
admet-661	117	8	0.1	0.1	NUM
admet-661	117	9	m	m	PROPN
admet-661	117	10	naoh	naoh	NOUN
admet-661	117	11	solution	solution	NOUN
admet-661	117	12	was	be	AUX
admet-661	117	13	added	add	VERB
admet-661	117	14	to	to	ADP
admet-661	117	15	cocrystal	cocrystal	VERB
admet-661	117	16	suspensions	suspension	NOUN
admet-661	117	17	and	and	CCONJ
admet-661	117	18	shaken	shake	VERB
admet-661	117	19	for	for	ADP
admet-661	117	20	96	96	NUM
admet-661	117	21	h	h	NOUN
admet-661	117	22	,	,	PUNCT
admet-661	117	23	and	and	CCONJ
admet-661	117	24	the	the	DET
admet-661	117	25	drug	drug	NOUN
admet-661	117	26	concentration	concentration	NOUN
admet-661	117	27	was	be	AUX
admet-661	117	28	determined	determine	VERB
admet-661	117	29	according	accord	VERB
admet-661	117	30	to	to	ADP
admet-661	117	31	the	the	DET
admet-661	117	32	method	method	NOUN
admet-661	117	33	described	describe	VERB
admet-661	117	34	above	above	ADV
admet-661	117	35	.	.	PUNCT
admet-661	118	1	the	the	DET
admet-661	118	2	solid	solid	ADJ
admet-661	118	3	phase	phase	NOUN
admet-661	118	4	in	in	ADP
admet-661	118	5	equilibrium	equilibrium	NOUN
admet-661	118	6	with	with	ADP
admet-661	118	7	a	a	DET
admet-661	118	8	suspension	suspension	NOUN
admet-661	118	9	was	be	AUX
admet-661	118	10	analyzed	analyze	VERB
admet-661	118	11	in	in	ADP
admet-661	118	12	situ	situ	NOUN
admet-661	118	13	intermittently	intermittently	ADV
admet-661	118	14	by	by	ADP
admet-661	118	15	raman	raman	NOUN
admet-661	118	16	spectroscopy	spectroscopy	NOUN
admet-661	118	17	and	and	CCONJ
admet-661	118	18	by	by	ADP
admet-661	118	19	dsc	dsc	NOUN
admet-661	118	20	at	at	ADP
admet-661	118	21	the	the	DET
admet-661	118	22	end	end	NOUN
admet-661	118	23	of	of	ADP
admet-661	118	24	the	the	DET
admet-661	118	25	experiment	experiment	NOUN
admet-661	118	26	for	for	ADP
admet-661	118	27	any	any	DET
admet-661	118	28	conversion	conversion	NOUN
admet-661	118	29	of	of	ADP
admet-661	118	30	cocrystal	cocrystal	NOUN
admet-661	118	31	to	to	PART
admet-661	118	32	free	free	ADJ
admet-661	118	33	base	base	NOUN
admet-661	118	34	.	.	PUNCT
admet-661	119	1	vasoya	vasoya	PROPN
admet-661	119	2	et	et	PROPN
admet-661	119	3	al	al	PROPN
admet-661	119	4	.	.	PROPN
admet-661	119	5	admet	admet	PROPN
admet-661	119	6	&	&	CCONJ
admet-661	119	7	dmpk	dmpk	PROPN
admet-661	119	8	7(2	7(2	NUM
admet-661	119	9	)	)	PUNCT
admet-661	119	10	(	(	PUNCT
admet-661	119	11	2019	2019	NUM
admet-661	119	12	)	)	PUNCT
admet-661	119	13	106	106	NUM
admet-661	119	14	-	-	SYM
admet-661	119	15	130	130	NUM
admet-661	119	16	112	112	NUM
admet-661	119	17	cocrystal	cocrystal	ADJ
admet-661	119	18	solubility	solubility	NOUN
admet-661	119	19	in	in	ADP
admet-661	119	20	buffered	buffer	VERB
admet-661	119	21	/	/	SYM
admet-661	119	22	non	non	ADJ
admet-661	119	23	-	-	ADJ
admet-661	119	24	buffered	buffered	ADJ
admet-661	119	25	media	medium	NOUN
admet-661	119	26	cocrystal	cocrystal	ADJ
admet-661	119	27	solubilities	solubility	NOUN
admet-661	119	28	were	be	AUX
admet-661	119	29	determined	determine	VERB
admet-661	119	30	at	at	ADP
admet-661	119	31	ph	ph	NOUN
admet-661	119	32	1	1	NUM
admet-661	119	33	solution	solution	NOUN
admet-661	119	34	(	(	PUNCT
admet-661	119	35	0.1	0.1	NUM
admet-661	119	36	m	m	NOUN
admet-661	119	37	hcl	hcl	PROPN
admet-661	119	38	)	)	PUNCT
admet-661	119	39	,	,	PUNCT
admet-661	119	40	ph	ph	PROPN
admet-661	119	41	2	2	NUM
admet-661	119	42	hcl	hcl	NOUN
admet-661	119	43	buffer	buffer	NOUN
admet-661	119	44	)	)	PUNCT
admet-661	119	45	,	,	PUNCT
admet-661	119	46	ph	ph	X
admet-661	119	47	5	5	NUM
admet-661	119	48	acetate	acetate	NOUN
admet-661	119	49	buffer	buffer	NOUN
admet-661	119	50	and	and	CCONJ
admet-661	119	51	ph	ph	ADJ
admet-661	119	52	8	8	NUM
admet-661	119	53	phosphate	phosphate	NOUN
admet-661	119	54	buffer	buffer	NOUN
admet-661	119	55	.	.	PUNCT
admet-661	120	1	buffers	buffer	NOUN
admet-661	120	2	were	be	AUX
admet-661	120	3	prepared	prepare	VERB
admet-661	120	4	according	accord	VERB
admet-661	120	5	to	to	ADP
admet-661	120	6	the	the	DET
admet-661	120	7	united	united	PROPN
admet-661	120	8	states	states	PROPN
admet-661	120	9	pharmacopeia	pharmacopeia	PROPN
admet-661	120	10	(	(	PUNCT
admet-661	120	11	usp	usp	NOUN
admet-661	120	12	)	)	PUNCT
admet-661	120	13	procedures	procedure	NOUN
admet-661	120	14	.	.	PUNCT
admet-661	121	1	for	for	ADP
admet-661	121	2	the	the	DET
admet-661	121	3	determination	determination	NOUN
admet-661	121	4	of	of	ADP
admet-661	121	5	solubility	solubility	NOUN
admet-661	121	6	,	,	PUNCT
admet-661	121	7	5	5	NUM
admet-661	121	8	ml	ml	NOUN
admet-661	121	9	of	of	ADP
admet-661	121	10	each	each	DET
admet-661	121	11	buffer	buffer	NOUN
admet-661	121	12	was	be	AUX
admet-661	121	13	equilibrated	equilibrate	VERB
admet-661	121	14	with	with	ADP
admet-661	121	15	excess	excess	ADJ
admet-661	121	16	cocrystal	cocrystal	NOUN
admet-661	121	17	in	in	ADP
admet-661	121	18	a	a	DET
admet-661	121	19	20	20	NUM
admet-661	121	20	ml	ml	NOUN
admet-661	121	21	glass	glass	NOUN
admet-661	121	22	vial	vial	ADJ
admet-661	121	23	and	and	CCONJ
admet-661	121	24	shaken	shake	VERB
admet-661	121	25	for	for	ADP
admet-661	121	26	96	96	NUM
admet-661	121	27	h	h	NOUN
admet-661	121	28	in	in	ADP
admet-661	121	29	a	a	DET
admet-661	121	30	water	water	NOUN
admet-661	121	31	bath	bath	NOUN
admet-661	121	32	shaker	shaker	NOUN
admet-661	121	33	at	at	ADP
admet-661	121	34	25	25	NUM
admet-661	121	35	°	°	NOUN
admet-661	121	36	c	c	NOUN
admet-661	121	37	,	,	PUNCT
admet-661	121	38	0.5	0.5	NUM
admet-661	121	39	-	-	SYM
admet-661	121	40	1	1	NUM
admet-661	121	41	ml	ml	NOUN
admet-661	121	42	of	of	ADP
admet-661	121	43	samples	sample	NOUN
admet-661	121	44	were	be	AUX
admet-661	121	45	withdrawn	withdraw	VERB
admet-661	121	46	at	at	ADP
admet-661	121	47	24	24	NUM
admet-661	121	48	and	and	CCONJ
admet-661	121	49	96	96	NUM
admet-661	121	50	h	h	NOUN
admet-661	121	51	,	,	PUNCT
admet-661	121	52	and	and	CCONJ
admet-661	121	53	ph	ph	NOUN
admet-661	121	54	of	of	ADP
admet-661	121	55	the	the	DET
admet-661	121	56	solution	solution	NOUN
admet-661	121	57	and	and	CCONJ
admet-661	121	58	concentration	concentration	NOUN
admet-661	121	59	of	of	ADP
admet-661	121	60	ketoconazole	ketoconazole	NOUN
admet-661	121	61	were	be	AUX
admet-661	121	62	measured	measure	VERB
admet-661	121	63	.	.	PUNCT
admet-661	122	1	aliquots	aliquot	NOUN
admet-661	122	2	were	be	AUX
admet-661	122	3	filtered	filter	VERB
admet-661	122	4	by	by	ADP
admet-661	122	5	0.45	0.45	NUM
admet-661	122	6	-	-	PUNCT
admet-661	122	7	micron	micron	NOUN
admet-661	122	8	pvdf	pvdf	NOUN
admet-661	122	9	filter	filter	NOUN
admet-661	122	10	and	and	CCONJ
admet-661	122	11	analyzed	analyze	VERB
admet-661	122	12	by	by	ADP
admet-661	122	13	hplc	hplc	PROPN
admet-661	122	14	.	.	PUNCT
admet-661	123	1	the	the	DET
admet-661	123	2	solid	solid	ADJ
admet-661	123	3	phase	phase	NOUN
admet-661	123	4	was	be	AUX
admet-661	123	5	analyzed	analyze	VERB
admet-661	123	6	by	by	ADP
admet-661	123	7	raman	raman	NOUN
admet-661	123	8	spectroscopy	spectroscopy	NOUN
admet-661	123	9	.	.	PUNCT
admet-661	124	1	ketoconazole	ketoconazole	NOUN
admet-661	124	2	solubility	solubility	NOUN
admet-661	124	3	by	by	ADP
admet-661	124	4	adjusting	adjust	VERB
admet-661	124	5	ph	ph	PROPN
admet-661	124	6	with	with	ADP
admet-661	124	7	fumaric	fumaric	ADJ
admet-661	124	8	acid	acid	PROPN
admet-661	124	9	and	and	CCONJ
admet-661	124	10	succinic	succinic	ADJ
admet-661	124	11	acid	acid	NOUN
admet-661	124	12	ph	ph	ADJ
admet-661	124	13	-	-	PUNCT
admet-661	124	14	solubility	solubility	NOUN
admet-661	124	15	profiles	profile	NOUN
admet-661	124	16	of	of	ADP
admet-661	124	17	ketoconazole	ketoconazole	NOUN
admet-661	124	18	were	be	AUX
admet-661	124	19	also	also	ADV
admet-661	124	20	generated	generate	VERB
admet-661	124	21	using	use	VERB
admet-661	124	22	the	the	DET
admet-661	124	23	two	two	NUM
admet-661	124	24	coformer	coformer	NOUN
admet-661	124	25	acids	acid	NOUN
admet-661	124	26	,	,	PUNCT
admet-661	124	27	e.g.	e.g.	ADV
admet-661	124	28	,	,	PUNCT
admet-661	124	29	succinic	succinic	ADJ
admet-661	124	30	acid	acid	NOUN
admet-661	124	31	and	and	CCONJ
admet-661	124	32	fumaric	fumaric	ADJ
admet-661	124	33	acid	acid	PROPN
admet-661	124	34	.	.	PUNCT
admet-661	125	1	a	a	DET
admet-661	125	2	series	series	NOUN
admet-661	125	3	of	of	ADP
admet-661	125	4	solutions	solution	NOUN
admet-661	125	5	with	with	ADP
admet-661	125	6	different	different	ADJ
admet-661	125	7	concentrations	concentration	NOUN
admet-661	125	8	of	of	ADP
admet-661	125	9	acids	acid	NOUN
admet-661	125	10	were	be	AUX
admet-661	125	11	prepared	prepare	VERB
admet-661	125	12	and	and	CCONJ
admet-661	125	13	3	3	NUM
admet-661	125	14	ml	ml	NOUN
admet-661	125	15	quantities	quantity	NOUN
admet-661	125	16	of	of	ADP
admet-661	125	17	these	these	DET
admet-661	125	18	solutions	solution	NOUN
admet-661	125	19	were	be	AUX
admet-661	125	20	distributed	distribute	VERB
admet-661	125	21	in	in	ADP
admet-661	125	22	separate	separate	ADJ
admet-661	125	23	glass	glass	NOUN
admet-661	125	24	vials	vial	NOUN
admet-661	125	25	.	.	PUNCT
admet-661	126	1	for	for	ADP
admet-661	126	2	the	the	DET
admet-661	126	3	determination	determination	NOUN
admet-661	126	4	of	of	ADP
admet-661	126	5	ketoconazole	ketoconazole	PROPN
admet-661	126	6	solubility	solubility	NOUN
admet-661	126	7	versus	versus	ADP
admet-661	126	8	ph	ph	NOUN
admet-661	126	9	using	use	VERB
admet-661	126	10	succinic	succinic	ADJ
admet-661	126	11	acid	acid	NOUN
admet-661	126	12	,	,	PUNCT
admet-661	126	13	the	the	DET
admet-661	126	14	concentration	concentration	NOUN
admet-661	126	15	of	of	ADP
admet-661	126	16	acid	acid	NOUN
admet-661	126	17	ranged	range	VERB
admet-661	126	18	from	from	ADP
admet-661	126	19	100	100	NUM
admet-661	126	20	µg	µg	NOUN
admet-661	126	21	/	/	SYM
admet-661	126	22	ml	ml	NOUN
admet-661	126	23	to	to	ADP
admet-661	126	24	50	50	NUM
admet-661	126	25	mg	mg	NOUN
admet-661	126	26	/	/	SYM
admet-661	126	27	ml	ml	NOUN
admet-661	126	28	,	,	PUNCT
admet-661	126	29	while	while	SCONJ
admet-661	126	30	,	,	PUNCT
admet-661	126	31	in	in	ADP
admet-661	126	32	case	case	NOUN
admet-661	126	33	of	of	ADP
admet-661	126	34	fumaric	fumaric	ADJ
admet-661	126	35	acid	acid	PROPN
admet-661	126	36	,	,	PUNCT
admet-661	126	37	the	the	DET
admet-661	126	38	concentration	concentration	NOUN
admet-661	126	39	of	of	ADP
admet-661	126	40	acid	acid	NOUN
admet-661	126	41	ranged	range	VERB
admet-661	126	42	50	50	NUM
admet-661	126	43	µg	µg	NOUN
admet-661	126	44	/	/	SYM
admet-661	126	45	ml	ml	NOUN
admet-661	126	46	to	to	ADP
admet-661	126	47	2	2	NUM
admet-661	126	48	mg	mg	NOUN
admet-661	126	49	/	/	SYM
admet-661	126	50	ml	ml	NOUN
admet-661	126	51	;	;	PUNCT
admet-661	126	52	the	the	DET
admet-661	126	53	difference	difference	NOUN
admet-661	126	54	in	in	ADP
admet-661	126	55	acid	acid	NOUN
admet-661	126	56	concentration	concentration	NOUN
admet-661	126	57	was	be	AUX
admet-661	126	58	due	due	ADJ
admet-661	126	59	to	to	ADP
admet-661	126	60	difference	difference	NOUN
admet-661	126	61	in	in	ADP
admet-661	126	62	aqueous	aqueous	ADJ
admet-661	126	63	solubility	solubility	NOUN
admet-661	126	64	of	of	ADP
admet-661	126	65	acids	acid	NOUN
admet-661	126	66	,	,	PUNCT
admet-661	126	67	fumaric	fumaric	ADJ
admet-661	126	68	acid	acid	NOUN
admet-661	126	69	being	be	AUX
admet-661	126	70	much	much	ADV
admet-661	126	71	less	less	ADV
admet-661	126	72	soluble	soluble	ADJ
admet-661	126	73	.	.	PUNCT
admet-661	127	1	to	to	ADP
admet-661	127	2	each	each	PRON
admet-661	127	3	of	of	ADP
admet-661	127	4	these	these	DET
admet-661	127	5	solutions	solution	NOUN
admet-661	127	6	,	,	PUNCT
admet-661	127	7	excess	excess	ADJ
admet-661	127	8	amounts	amount	NOUN
admet-661	127	9	of	of	ADP
admet-661	127	10	ketoconazole	ketoconazole	NOUN
admet-661	127	11	(	(	PUNCT
admet-661	127	12	~10	~10	NOUN
admet-661	127	13	-	-	SYM
admet-661	127	14	15	15	NUM
admet-661	127	15	mg	mg	NOUN
admet-661	127	16	more	more	ADJ
admet-661	127	17	than	than	ADP
admet-661	127	18	the	the	DET
admet-661	127	19	expected	expect	VERB
admet-661	127	20	solubility	solubility	NOUN
admet-661	127	21	at	at	ADP
admet-661	127	22	a	a	DET
admet-661	127	23	specific	specific	ADJ
admet-661	127	24	ph	ph	NOUN
admet-661	127	25	)	)	PUNCT
admet-661	127	26	was	be	AUX
admet-661	127	27	added	add	VERB
admet-661	127	28	and	and	CCONJ
admet-661	127	29	kept	keep	VERB
admet-661	127	30	for	for	ADP
admet-661	127	31	shaking	shake	VERB
admet-661	127	32	in	in	ADP
admet-661	127	33	a	a	DET
admet-661	127	34	water	water	NOUN
admet-661	127	35	bath	bath	NOUN
admet-661	127	36	shaker	shaker	NOUN
admet-661	127	37	at	at	ADP
admet-661	127	38	25	25	NUM
admet-661	127	39	°	°	NOUN
admet-661	127	40	c	c	NOUN
admet-661	127	41	for	for	ADP
admet-661	127	42	up	up	ADP
admet-661	127	43	to	to	PART
admet-661	127	44	96	96	NUM
admet-661	127	45	h.	h.	NOUN
admet-661	127	46	aliquots	aliquot	NOUN
admet-661	127	47	of	of	ADP
admet-661	127	48	suspensions	suspension	NOUN
admet-661	127	49	(	(	PUNCT
admet-661	127	50	0.5	0.5	NUM
admet-661	127	51	-	-	SYM
admet-661	127	52	0.7	0.7	NUM
admet-661	127	53	ml	ml	NOUN
admet-661	127	54	each	each	PRON
admet-661	127	55	)	)	PUNCT
admet-661	128	1	were	be	AUX
admet-661	128	2	,	,	PUNCT
admet-661	128	3	however	however	ADV
admet-661	128	4	,	,	PUNCT
admet-661	128	5	withdrawn	withdraw	VERB
admet-661	128	6	from	from	ADP
admet-661	128	7	each	each	DET
admet-661	128	8	vial	vial	NOUN
admet-661	128	9	after	after	ADP
admet-661	128	10	4	4	NUM
admet-661	128	11	,	,	PUNCT
admet-661	128	12	24	24	NUM
admet-661	128	13	and	and	CCONJ
admet-661	128	14	96	96	NUM
admet-661	128	15	h	h	NOUN
admet-661	128	16	of	of	ADP
admet-661	128	17	shaking	shake	VERB
admet-661	128	18	for	for	ADP
admet-661	128	19	analysis	analysis	NOUN
admet-661	128	20	of	of	ADP
admet-661	128	21	drug	drug	NOUN
admet-661	128	22	concentration	concentration	NOUN
admet-661	128	23	by	by	ADP
admet-661	128	24	hplc	hplc	NOUN
admet-661	128	25	according	accord	VERB
admet-661	128	26	to	to	ADP
admet-661	128	27	the	the	DET
admet-661	128	28	method	method	NOUN
admet-661	128	29	described	describe	VERB
admet-661	128	30	earlier	early	ADV
admet-661	128	31	.	.	PUNCT
admet-661	129	1	for	for	ADP
admet-661	129	2	the	the	DET
admet-661	129	3	analysis	analysis	NOUN
admet-661	129	4	of	of	ADP
admet-661	129	5	solid	solid	ADJ
admet-661	129	6	phase	phase	NOUN
admet-661	129	7	,	,	PUNCT
admet-661	129	8	contents	content	NOUN
admet-661	129	9	of	of	ADP
admet-661	129	10	the	the	DET
admet-661	129	11	vials	vial	NOUN
admet-661	129	12	were	be	AUX
admet-661	129	13	transferred	transfer	VERB
admet-661	129	14	to	to	ADP
admet-661	129	15	3	3	NUM
admet-661	129	16	-	-	PUNCT
admet-661	129	17	ml	ml	NOUN
admet-661	129	18	eppendorf	eppendorf	PROPN
admet-661	129	19	tubes	tube	NOUN
admet-661	129	20	and	and	CCONJ
admet-661	129	21	centrifuged	centrifuge	VERB
admet-661	129	22	using	use	VERB
admet-661	129	23	beckman	beckman	PROPN
admet-661	129	24	gs	gs	PROPN
admet-661	129	25	6r	6r	NUM
admet-661	129	26	centrifuge	centrifuge	NOUN
admet-661	129	27	at	at	ADP
admet-661	129	28	2000	2000	NUM
admet-661	129	29	rpm	rpm	NOUN
admet-661	129	30	for	for	ADP
admet-661	129	31	5	5	NUM
admet-661	129	32	min	min	NOUN
admet-661	129	33	.	.	PROPN
admet-661	130	1	after	after	ADP
admet-661	130	2	centrifugation	centrifugation	NOUN
admet-661	130	3	,	,	PUNCT
admet-661	130	4	the	the	DET
admet-661	130	5	supernatants	supernatant	NOUN
admet-661	130	6	were	be	AUX
admet-661	130	7	removed	remove	VERB
admet-661	130	8	and	and	CCONJ
admet-661	130	9	solid	solid	ADJ
admet-661	130	10	contents	content	NOUN
admet-661	130	11	were	be	AUX
admet-661	130	12	dried	dry	VERB
admet-661	130	13	in	in	ADP
admet-661	130	14	a	a	DET
admet-661	130	15	vacuum	vacuum	NOUN
admet-661	130	16	oven	oven	NOUN
admet-661	130	17	at	at	ADP
admet-661	130	18	50	50	NUM
admet-661	130	19	°	°	NOUN
admet-661	130	20	c	c	NOUN
admet-661	130	21	,	,	PUNCT
admet-661	130	22	which	which	PRON
admet-661	130	23	were	be	AUX
admet-661	130	24	then	then	ADV
admet-661	130	25	analyzed	analyze	VERB
admet-661	130	26	by	by	ADP
admet-661	130	27	dsc	dsc	NOUN
admet-661	130	28	and	and	CCONJ
admet-661	130	29	raman	raman	NOUN
admet-661	130	30	spectroscopy	spectroscopy	NOUN
admet-661	130	31	.	.	PUNCT
admet-661	131	1	solubility	solubility	NOUN
admet-661	131	2	of	of	ADP
admet-661	131	3	1:1	1:1	NUM
admet-661	131	4	physical	physical	ADJ
admet-661	131	5	mixtures	mixture	NOUN
admet-661	131	6	of	of	ADP
admet-661	131	7	ketoconazole	ketoconazole	NOUN
admet-661	131	8	with	with	ADP
admet-661	131	9	different	different	ADJ
admet-661	131	10	coformers	coformer	NOUN
admet-661	131	11	aqueous	aqueous	ADJ
admet-661	131	12	solubility	solubility	NOUN
admet-661	131	13	was	be	AUX
admet-661	131	14	also	also	ADV
admet-661	131	15	determined	determine	VERB
admet-661	131	16	for	for	ADP
admet-661	131	17	1:1	1:1	NUM
admet-661	131	18	molar	molar	ADJ
admet-661	131	19	physical	physical	ADJ
admet-661	131	20	mixtures	mixture	NOUN
admet-661	131	21	of	of	ADP
admet-661	131	22	ketoconazole	ketoconazole	NOUN
admet-661	131	23	with	with	ADP
admet-661	131	24	each	each	PRON
admet-661	131	25	of	of	ADP
admet-661	131	26	the	the	DET
admet-661	131	27	coformers	coformer	NOUN
admet-661	131	28	(	(	PUNCT
admet-661	131	29	succinic	succinic	ADJ
admet-661	131	30	acid	acid	NOUN
admet-661	131	31	and	and	CCONJ
admet-661	131	32	fumaric	fumaric	ADJ
admet-661	131	33	acid	acid	PROPN
admet-661	131	34	)	)	PUNCT
admet-661	131	35	.	.	PUNCT
admet-661	132	1	in	in	ADP
admet-661	132	2	this	this	DET
admet-661	132	3	study	study	NOUN
admet-661	132	4	,	,	PUNCT
admet-661	132	5	different	different	ADJ
admet-661	132	6	quantities	quantity	NOUN
admet-661	132	7	of	of	ADP
admet-661	132	8	the	the	DET
admet-661	132	9	mixtures	mixture	NOUN
admet-661	132	10	(	(	PUNCT
admet-661	132	11	12	12	NUM
admet-661	132	12	mg	mg	NOUN
admet-661	132	13	to	to	ADP
admet-661	132	14	350	350	NUM
admet-661	132	15	mg	mg	NOUN
admet-661	132	16	)	)	PUNCT
admet-661	132	17	were	be	AUX
admet-661	132	18	added	add	VERB
admet-661	132	19	to	to	ADP
admet-661	132	20	different	different	ADJ
admet-661	132	21	20	20	NUM
admet-661	132	22	ml	ml	NOUN
admet-661	132	23	glass	glass	NOUN
admet-661	132	24	vials	vial	NOUN
admet-661	132	25	,	,	PUNCT
admet-661	132	26	and	and	CCONJ
admet-661	132	27	then	then	ADV
admet-661	132	28	5	5	NUM
admet-661	132	29	ml	ml	NOUN
admet-661	132	30	of	of	ADP
admet-661	132	31	water	water	NOUN
admet-661	132	32	was	be	AUX
admet-661	132	33	added	add	VERB
admet-661	132	34	to	to	ADP
admet-661	132	35	each	each	DET
admet-661	132	36	vial	vial	NOUN
admet-661	132	37	.	.	PUNCT
admet-661	133	1	thus	thus	ADV
admet-661	133	2	,	,	PUNCT
admet-661	133	3	the	the	DET
admet-661	133	4	volume	volume	NOUN
admet-661	133	5	of	of	ADP
admet-661	133	6	water	water	NOUN
admet-661	133	7	in	in	ADP
admet-661	133	8	each	each	DET
admet-661	133	9	vial	vial	NOUN
admet-661	133	10	remained	remain	VERB
admet-661	133	11	the	the	DET
admet-661	133	12	same	same	ADJ
admet-661	133	13	and	and	CCONJ
admet-661	133	14	only	only	ADV
admet-661	133	15	the	the	DET
admet-661	133	16	amount	amount	NOUN
admet-661	133	17	of	of	ADP
admet-661	133	18	material	material	NOUN
admet-661	133	19	added	add	VERB
admet-661	133	20	differed	differ	VERB
admet-661	133	21	.	.	PUNCT
admet-661	134	1	the	the	DET
admet-661	134	2	vials	vial	NOUN
admet-661	134	3	were	be	AUX
admet-661	134	4	shaken	shake	VERB
admet-661	134	5	in	in	ADP
admet-661	134	6	the	the	DET
admet-661	134	7	water	water	NOUN
admet-661	134	8	bath	bath	NOUN
admet-661	134	9	shaker	shaker	NOUN
admet-661	134	10	at	at	ADP
admet-661	134	11	25	25	NUM
admet-661	134	12	°	°	NOUN
admet-661	134	13	c	c	NOUN
admet-661	134	14	and	and	CCONJ
admet-661	134	15	250	250	NUM
admet-661	134	16	rpm	rpm	NOUN
admet-661	134	17	to	to	PART
admet-661	134	18	achieve	achieve	VERB
admet-661	134	19	equilibrium	equilibrium	NOUN
admet-661	134	20	solubility	solubility	NOUN
admet-661	134	21	.	.	PUNCT
admet-661	135	1	ph	ph	PROPN
admet-661	135	2	of	of	ADP
admet-661	135	3	the	the	DET
admet-661	135	4	suspensions	suspension	NOUN
admet-661	135	5	differed	differ	VERB
admet-661	135	6	because	because	SCONJ
admet-661	135	7	there	there	PRON
admet-661	135	8	were	be	VERB
admet-661	135	9	different	different	ADJ
admet-661	135	10	amounts	amount	NOUN
admet-661	135	11	of	of	ADP
admet-661	135	12	acids	acid	NOUN
admet-661	135	13	added	add	VERB
admet-661	135	14	in	in	ADP
admet-661	135	15	the	the	DET
admet-661	135	16	same	same	ADJ
admet-661	135	17	volume	volume	NOUN
admet-661	135	18	of	of	ADP
admet-661	135	19	water	water	NOUN
admet-661	135	20	,	,	PUNCT
admet-661	135	21	and	and	CCONJ
admet-661	135	22	all	all	DET
admet-661	135	23	the	the	DET
admet-661	135	24	acids	acid	NOUN
admet-661	135	25	dissolved	dissolve	VERB
admet-661	135	26	in	in	ADP
admet-661	135	27	water	water	NOUN
admet-661	135	28	.	.	PUNCT
admet-661	136	1	samples	sample	NOUN
admet-661	136	2	were	be	AUX
admet-661	136	3	withdrawn	withdraw	VERB
admet-661	136	4	from	from	ADP
admet-661	136	5	each	each	DET
admet-661	136	6	vial	vial	NOUN
admet-661	136	7	at	at	ADP
admet-661	136	8	4	4	NUM
admet-661	136	9	,	,	PUNCT
admet-661	136	10	24	24	NUM
admet-661	136	11	and	and	CCONJ
admet-661	136	12	96	96	NUM
admet-661	136	13	h	h	NOUN
admet-661	136	14	to	to	PART
admet-661	136	15	measure	measure	VERB
admet-661	136	16	drug	drug	NOUN
admet-661	136	17	concentration	concentration	NOUN
admet-661	136	18	,	,	PUNCT
admet-661	136	19	as	as	SCONJ
admet-661	136	20	described	describe	VERB
admet-661	136	21	earlier	early	ADV
admet-661	136	22	.	.	PUNCT
admet-661	137	1	the	the	DET
admet-661	137	2	solid	solid	ADJ
admet-661	137	3	phase	phase	NOUN
admet-661	137	4	of	of	ADP
admet-661	137	5	the	the	DET
admet-661	137	6	vials	vial	NOUN
admet-661	137	7	was	be	AUX
admet-661	137	8	analyzed	analyze	VERB
admet-661	137	9	using	use	VERB
admet-661	137	10	raman	raman	NOUN
admet-661	137	11	spectroscopy	spectroscopy	NOUN
admet-661	137	12	to	to	PART
admet-661	137	13	determine	determine	VERB
admet-661	137	14	the	the	DET
admet-661	137	15	identity	identity	NOUN
admet-661	137	16	of	of	ADP
admet-661	137	17	equilibrium	equilibrium	NOUN
admet-661	137	18	species	specie	NOUN
admet-661	137	19	.	.	PUNCT
admet-661	138	1	from	from	ADP
admet-661	138	2	some	some	PRON
admet-661	138	3	of	of	ADP
admet-661	138	4	the	the	DET
admet-661	138	5	vials	vial	NOUN
admet-661	138	6	,	,	PUNCT
admet-661	138	7	solid	solid	ADJ
admet-661	138	8	contents	content	NOUN
admet-661	138	9	were	be	AUX
admet-661	138	10	separated	separate	VERB
admet-661	138	11	by	by	ADP
admet-661	138	12	centrifugation	centrifugation	NOUN
admet-661	138	13	,	,	PUNCT
admet-661	138	14	dried	dry	VERB
admet-661	138	15	in	in	ADP
admet-661	138	16	a	a	DET
admet-661	138	17	vacuum	vacuum	NOUN
admet-661	138	18	oven	oven	NOUN
admet-661	138	19	,	,	PUNCT
admet-661	138	20	and	and	CCONJ
admet-661	138	21	then	then	ADV
admet-661	138	22	analyzed	analyze	VERB
admet-661	138	23	by	by	ADP
admet-661	138	24	dsc	dsc	PROPN
admet-661	138	25	.	.	PUNCT
admet-661	139	1	intrinsic	intrinsic	ADJ
admet-661	139	2	dissolution	dissolution	PROPN
admet-661	139	3	rate	rate	NOUN
admet-661	139	4	intrinsic	intrinsic	ADJ
admet-661	139	5	dissolution	dissolution	ADJ
admet-661	139	6	profiles	profile	NOUN
admet-661	139	7	of	of	ADP
admet-661	139	8	ketoconazole	ketoconazole	PROPN
admet-661	139	9	free	free	ADJ
admet-661	139	10	base	base	NOUN
admet-661	139	11	and	and	CCONJ
admet-661	139	12	its	its	PRON
admet-661	139	13	cocrystals	cocrystal	NOUN
admet-661	139	14	were	be	AUX
admet-661	139	15	determined	determine	VERB
admet-661	139	16	using	use	VERB
admet-661	139	17	an	an	DET
admet-661	139	18	intrinsic	intrinsic	ADJ
admet-661	139	19	dissolution	dissolution	NOUN
admet-661	139	20	apparatus	apparatus	NOUN
admet-661	139	21	(	(	PUNCT
admet-661	139	22	agilent	agilent	PROPN
admet-661	139	23	technologies	technologies	PROPN
admet-661	139	24	,	,	PUNCT
admet-661	139	25	santa	santa	PROPN
admet-661	139	26	clara	clara	PROPN
admet-661	139	27	,	,	PUNCT
admet-661	139	28	ca	ca	NOUN
admet-661	139	29	)	)	PUNCT
admet-661	139	30	with	with	ADP
admet-661	139	31	0.5	0.5	NUM
admet-661	139	32	cm2	cm2	NOUN
admet-661	139	33	exposed	expose	VERB
admet-661	139	34	surface	surface	NOUN
admet-661	139	35	area	area	NOUN
admet-661	139	36	at	at	ADP
admet-661	139	37	25	25	NUM
admet-661	139	38	°	°	NOUN
admet-661	139	39	c	c	NOUN
admet-661	139	40	.	.	PUNCT
admet-661	140	1	for	for	ADP
admet-661	140	2	each	each	DET
admet-661	140	3	determination	determination	NOUN
admet-661	140	4	,	,	PUNCT
admet-661	140	5	100	100	NUM
admet-661	140	6	mg	mg	NOUN
admet-661	140	7	of	of	ADP
admet-661	140	8	powder	powder	NOUN
admet-661	140	9	was	be	AUX
admet-661	140	10	compressed	compress	VERB
admet-661	140	11	into	into	ADP
admet-661	140	12	pellet	pellet	NOUN
admet-661	140	13	by	by	ADP
admet-661	140	14	carver	carver	NOUN
admet-661	140	15	press	press	NOUN
admet-661	140	16	at	at	ADP
admet-661	140	17	1	1	NUM
admet-661	140	18	ton	ton	NOUN
admet-661	140	19	pressure	pressure	NOUN
admet-661	140	20	for	for	ADP
admet-661	140	21	10	10	NUM
admet-661	140	22	seconds	second	NOUN
admet-661	140	23	.	.	PUNCT
admet-661	141	1	the	the	DET
admet-661	141	2	apparatus	apparatus	NOUN
admet-661	141	3	with	with	ADP
admet-661	141	4	the	the	DET
admet-661	141	5	exposed	expose	VERB
admet-661	141	6	surface	surface	NOUN
admet-661	141	7	of	of	ADP
admet-661	141	8	the	the	DET
admet-661	141	9	material	material	NOUN
admet-661	141	10	was	be	AUX
admet-661	141	11	immersed	immerse	VERB
admet-661	141	12	into	into	ADP
admet-661	141	13	250	250	NUM
admet-661	141	14	ml	ml	NOUN
admet-661	141	15	of	of	ADP
admet-661	141	16	dissolution	dissolution	NOUN
admet-661	141	17	medium	medium	NOUN
admet-661	141	18	and	and	CCONJ
admet-661	141	19	rotated	rotate	VERB
admet-661	141	20	at	at	ADP
admet-661	141	21	200	200	NUM
admet-661	141	22	rpm	rpm	NOUN
admet-661	141	23	.	.	PUNCT
admet-661	142	1	ph	ph	PROPN
admet-661	142	2	of	of	ADP
admet-661	142	3	dissolution	dissolution	NOUN
admet-661	142	4	media	medium	NOUN
admet-661	142	5	during	during	ADP
admet-661	142	6	the	the	DET
admet-661	142	7	intrinsic	intrinsic	ADJ
admet-661	142	8	dissolution	dissolution	NOUN
admet-661	142	9	testing	testing	NOUN
admet-661	142	10	were	be	AUX
admet-661	142	11	maintained	maintain	VERB
admet-661	142	12	by	by	ADP
admet-661	142	13	two	two	NUM
admet-661	142	14	different	different	ADJ
admet-661	142	15	methods	method	NOUN
admet-661	142	16	:	:	PUNCT
admet-661	142	17	in	in	ADP
admet-661	142	18	one	one	NUM
admet-661	142	19	case	case	NOUN
admet-661	142	20	,	,	PUNCT
admet-661	142	21	unbuffered	unbuffered	ADJ
admet-661	142	22	media	medium	NOUN
admet-661	142	23	were	be	AUX
admet-661	142	24	used	use	VERB
admet-661	142	25	where	where	SCONJ
admet-661	142	26	either	either	CCONJ
admet-661	142	27	0.1	0.1	NUM
admet-661	142	28	m	m	NOUN
admet-661	142	29	hcl	hcl	PROPN
admet-661	142	30	or	or	CCONJ
admet-661	142	31	0.1	0.1	NUM
admet-661	142	32	m	m	PROPN
admet-661	142	33	naoh	naoh	NOUN
admet-661	142	34	were	be	AUX
admet-661	142	35	added	add	VERB
admet-661	142	36	to	to	PART
admet-661	142	37	keep	keep	VERB
admet-661	142	38	ph	ph	ADJ
admet-661	142	39	constant	constant	ADJ
admet-661	142	40	at	at	ADP
admet-661	142	41	3	3	NUM
admet-661	142	42	,	,	PUNCT
admet-661	142	43	4	4	NUM
admet-661	142	44	or	or	CCONJ
admet-661	142	45	5	5	NUM
admet-661	142	46	(	(	PUNCT
admet-661	142	47	±0.15	±0.15	PROPN
admet-661	142	48	)	)	PUNCT
admet-661	142	49	,	,	PUNCT
admet-661	142	50	and	and	CCONJ
admet-661	142	51	in	in	ADP
admet-661	142	52	the	the	DET
admet-661	142	53	second	second	ADJ
admet-661	142	54	case	case	NOUN
admet-661	142	55	,	,	PUNCT
admet-661	142	56	ph	ph	NOUN
admet-661	142	57	3	3	NUM
admet-661	142	58	,	,	PUNCT
admet-661	142	59	4	4	NUM
admet-661	142	60	and	and	CCONJ
admet-661	142	61	5	5	NUM
admet-661	142	62	phthalate	phthalate	NOUN
admet-661	142	63	buffers	buffer	NOUN
admet-661	142	64	prepared	prepare	VERB
admet-661	142	65	according	accord	VERB
admet-661	142	66	to	to	ADP
admet-661	142	67	the	the	DET
admet-661	142	68	usp	usp	NOUN
admet-661	142	69	were	be	AUX
admet-661	142	70	used	use	VERB
admet-661	142	71	as	as	ADP
admet-661	142	72	dissolution	dissolution	ADJ
admet-661	142	73	media	medium	NOUN
admet-661	142	74	to	to	PART
admet-661	142	75	keep	keep	VERB
admet-661	142	76	ph	ph	ADJ
admet-661	142	77	admet	admet	PROPN
admet-661	142	78	&	&	CCONJ
admet-661	142	79	dmpk	dmpk	PROPN
admet-661	142	80	7(2	7(2	NUM
admet-661	142	81	)	)	PUNCT
admet-661	142	82	(	(	PUNCT
admet-661	142	83	2019	2019	NUM
admet-661	142	84	)	)	PUNCT
admet-661	142	85	106	106	NUM
admet-661	142	86	-	-	SYM
admet-661	142	87	130	130	NUM
admet-661	142	88	solubility	solubility	NOUN
admet-661	142	89	and	and	CCONJ
admet-661	142	90	dissolution	dissolution	NOUN
admet-661	142	91	of	of	ADP
admet-661	142	92	cocrystals	cocrystal	NOUN
admet-661	142	93	doi	doi	NOUN
admet-661	142	94	:	:	PUNCT
admet-661	142	95	10.5599	10.5599	NUM
admet-661	142	96	/	/	SYM
admet-661	143	1	admet.661	admet.661	PROPN
admet-661	143	2	113	113	NUM
admet-661	143	3	constant	constant	ADJ
admet-661	143	4	.	.	PUNCT
admet-661	144	1	two	two	NUM
admet-661	144	2	ml	ml	NOUN
admet-661	144	3	of	of	ADP
admet-661	144	4	aliquot	aliquot	NOUN
admet-661	144	5	was	be	AUX
admet-661	144	6	withdrawn	withdraw	VERB
admet-661	144	7	at	at	ADP
admet-661	144	8	each	each	PRON
admet-661	144	9	of	of	ADP
admet-661	144	10	5	5	NUM
admet-661	144	11	,	,	PUNCT
admet-661	144	12	15	15	NUM
admet-661	144	13	,	,	PUNCT
admet-661	144	14	30	30	NUM
admet-661	144	15	,	,	PUNCT
admet-661	144	16	60	60	NUM
admet-661	144	17	,	,	PUNCT
admet-661	144	18	90	90	NUM
admet-661	144	19	and	and	CCONJ
admet-661	144	20	120	120	NUM
admet-661	144	21	min	min	NOUN
admet-661	144	22	time	time	NOUN
admet-661	144	23	points	point	NOUN
admet-661	144	24	,	,	PUNCT
admet-661	144	25	filtered	filter	VERB
admet-661	144	26	by	by	ADP
admet-661	144	27	0.45	0.45	NUM
admet-661	144	28	-	-	PUNCT
admet-661	144	29	micron	micron	NOUN
admet-661	144	30	pvdf	pvdf	PROPN
admet-661	144	31	filter	filter	NOUN
admet-661	144	32	,	,	PUNCT
admet-661	144	33	and	and	CCONJ
admet-661	144	34	analyzed	analyze	VERB
admet-661	144	35	by	by	ADP
admet-661	144	36	hplc	hplc	NOUN
admet-661	144	37	for	for	ADP
admet-661	144	38	drug	drug	NOUN
admet-661	144	39	concentration	concentration	NOUN
admet-661	144	40	.	.	PUNCT
admet-661	145	1	results	result	NOUN
admet-661	145	2	and	and	CCONJ
admet-661	145	3	discussion	discussion	NOUN
admet-661	145	4	ketoconazole	ketoconazole	PROPN
admet-661	145	5	cocrystals	cocrystal	VERB
admet-661	145	6	ketoconazole	ketoconazole	PROPN
admet-661	145	7	-	-	PUNCT
admet-661	145	8	fumaric	fumaric	NOUN
admet-661	145	9	acid	acid	NOUN
admet-661	145	10	and	and	CCONJ
admet-661	145	11	ketoconazole	ketoconazole	NOUN
admet-661	145	12	-	-	PUNCT
admet-661	145	13	succinic	succinic	ADJ
admet-661	145	14	acid	acid	NOUN
admet-661	145	15	cocrystals	cocrystal	NOUN
admet-661	145	16	prepared	prepare	VERB
admet-661	145	17	by	by	ADP
admet-661	145	18	the	the	DET
admet-661	145	19	solvent	solvent	NOUN
admet-661	145	20	evaporation	evaporation	NOUN
admet-661	145	21	method	method	NOUN
admet-661	145	22	in	in	ADP
admet-661	145	23	the	the	DET
admet-661	145	24	present	present	ADJ
admet-661	145	25	investigation	investigation	NOUN
admet-661	145	26	were	be	AUX
admet-661	145	27	analyzed	analyze	VERB
admet-661	145	28	by	by	ADP
admet-661	145	29	differential	differential	NOUN
admet-661	145	30	scanning	scanning	NOUN
admet-661	145	31	calorimetry	calorimetry	NOUN
admet-661	145	32	(	(	PUNCT
admet-661	145	33	dsc	dsc	NOUN
admet-661	145	34	)	)	PUNCT
admet-661	145	35	and	and	CCONJ
admet-661	145	36	powder	powder	NOUN
admet-661	145	37	x	x	NOUN
admet-661	145	38	-	-	NOUN
admet-661	145	39	ray	ray	NOUN
admet-661	145	40	diffraction	diffraction	NOUN
admet-661	145	41	(	(	PUNCT
admet-661	145	42	pxrd	pxrd	PROPN
admet-661	145	43	)	)	PUNCT
admet-661	145	44	to	to	PART
admet-661	145	45	assess	assess	VERB
admet-661	145	46	their	their	PRON
admet-661	145	47	crystallinity	crystallinity	NOUN
admet-661	145	48	and	and	CCONJ
admet-661	145	49	purity	purity	NOUN
admet-661	145	50	.	.	PUNCT
admet-661	146	1	dsc	dsc	NOUN
admet-661	146	2	scans	scan	NOUN
admet-661	146	3	of	of	ADP
admet-661	146	4	two	two	NUM
admet-661	146	5	cocrystals	cocrystal	NOUN
admet-661	146	6	as	as	ADV
admet-661	146	7	well	well	ADV
admet-661	146	8	as	as	ADP
admet-661	146	9	those	those	PRON
admet-661	146	10	of	of	ADP
admet-661	146	11	parent	parent	NOUN
admet-661	146	12	compounds	compound	NOUN
admet-661	146	13	(	(	PUNCT
admet-661	146	14	ketoconazole	ketoconazole	NOUN
admet-661	146	15	,	,	PUNCT
admet-661	146	16	fumaric	fumaric	ADJ
admet-661	146	17	acid	acid	PROPN
admet-661	146	18	and	and	CCONJ
admet-661	146	19	succinic	succinic	ADJ
admet-661	146	20	acid	acid	NOUN
admet-661	146	21	)	)	PUNCT
admet-661	146	22	are	be	AUX
admet-661	146	23	shown	show	VERB
admet-661	146	24	in	in	ADP
admet-661	146	25	fig	fig	NOUN
admet-661	146	26	.	.	PUNCT
admet-661	147	1	1	1	NUM
admet-661	147	2	,	,	PUNCT
admet-661	147	3	and	and	CCONJ
admet-661	147	4	the	the	DET
admet-661	147	5	corresponding	correspond	VERB
admet-661	147	6	pxrd	pxrd	NOUN
admet-661	147	7	patterns	pattern	NOUN
admet-661	147	8	are	be	AUX
admet-661	147	9	given	give	VERB
admet-661	147	10	in	in	ADP
admet-661	147	11	fig	fig	NOUN
admet-661	147	12	.	.	PUNCT
admet-661	148	1	2	2	X
admet-661	148	2	.	.	X
admet-661	148	3	ketoconazole	ketoconazole	PROPN
admet-661	148	4	showed	show	VERB
admet-661	148	5	a	a	DET
admet-661	148	6	melting	melting	NOUN
admet-661	148	7	endotherm	endotherm	NOUN
admet-661	148	8	at	at	ADP
admet-661	148	9	150	150	NUM
admet-661	148	10	°	°	NOUN
admet-661	148	11	c	c	NOUN
admet-661	148	12	,	,	PUNCT
admet-661	148	13	while	while	SCONJ
admet-661	148	14	ketoconazole	ketoconazole	NOUN
admet-661	148	15	-	-	PUNCT
admet-661	148	16	fumaric	fumaric	NOUN
admet-661	148	17	acid	acid	NOUN
admet-661	148	18	and	and	CCONJ
admet-661	148	19	ketoconazole	ketoconazole	NOUN
admet-661	148	20	-	-	PUNCT
admet-661	148	21	succinic	succinic	ADJ
admet-661	148	22	acid	acid	NOUN
admet-661	148	23	cocrystals	cocrystal	NOUN
admet-661	148	24	showed	show	VERB
admet-661	148	25	melting	melt	VERB
admet-661	148	26	endotherms	endotherm	NOUN
admet-661	148	27	at	at	ADP
admet-661	148	28	170	170	NUM
admet-661	148	29	°	°	ADP
admet-661	148	30	c	c	NOUN
admet-661	148	31	and	and	CCONJ
admet-661	148	32	167	167	NUM
admet-661	148	33	°	°	NOUN
admet-661	148	34	c	c	NOUN
admet-661	148	35	,	,	PUNCT
admet-661	148	36	respectively	respectively	ADV
admet-661	148	37	;	;	PUNCT
admet-661	148	38	these	these	DET
admet-661	148	39	values	value	NOUN
admet-661	148	40	are	be	AUX
admet-661	148	41	in	in	ADP
admet-661	148	42	agreement	agreement	NOUN
admet-661	148	43	with	with	ADP
admet-661	148	44	those	those	PRON
admet-661	148	45	reported	report	VERB
admet-661	148	46	elsewhere	elsewhere	ADV
admet-661	148	47	in	in	ADP
admet-661	148	48	the	the	DET
admet-661	148	49	literature	literature	NOUN
admet-661	148	50	[	[	X
admet-661	148	51	28	28	NUM
admet-661	148	52	]	]	PUNCT
admet-661	148	53	.	.	PUNCT
admet-661	149	1	the	the	DET
admet-661	149	2	relatively	relatively	ADV
admet-661	149	3	sharp	sharp	ADJ
admet-661	149	4	endotherms	endotherm	NOUN
admet-661	149	5	indicated	indicate	VERB
admet-661	149	6	that	that	SCONJ
admet-661	149	7	the	the	DET
admet-661	149	8	cocrystals	cocrystal	NOUN
admet-661	149	9	were	be	AUX
admet-661	149	10	highly	highly	ADV
admet-661	149	11	crystalline	crystalline	ADJ
admet-661	149	12	,	,	PUNCT
admet-661	149	13	and	and	CCONJ
admet-661	149	14	the	the	DET
admet-661	149	15	absence	absence	NOUN
admet-661	149	16	of	of	ADP
admet-661	149	17	any	any	DET
admet-661	149	18	separate	separate	ADJ
admet-661	149	19	peaks	peak	NOUN
admet-661	149	20	for	for	ADP
admet-661	149	21	ketoconazole	ketoconazole	NOUN
admet-661	149	22	alone	alone	ADV
admet-661	149	23	or	or	CCONJ
admet-661	149	24	free	free	ADJ
admet-661	149	25	acids	acid	NOUN
admet-661	149	26	in	in	ADP
admet-661	149	27	dsc	dsc	NOUN
admet-661	149	28	scans	scan	NOUN
admet-661	149	29	confirmed	confirm	VERB
admet-661	149	30	the	the	DET
admet-661	149	31	absence	absence	NOUN
admet-661	149	32	of	of	ADP
admet-661	149	33	any	any	DET
admet-661	149	34	impurity	impurity	NOUN
admet-661	149	35	due	due	ADP
admet-661	149	36	to	to	ADP
admet-661	149	37	the	the	DET
admet-661	149	38	presence	presence	NOUN
admet-661	149	39	of	of	ADP
admet-661	149	40	unconverted	unconverte	VERB
admet-661	149	41	ketoconazole	ketoconazole	NOUN
admet-661	149	42	or	or	CCONJ
admet-661	149	43	coformers	coformer	NOUN
admet-661	149	44	in	in	ADP
admet-661	149	45	cocrystals	cocrystal	NOUN
admet-661	149	46	.	.	PUNCT
admet-661	150	1	the	the	DET
admet-661	150	2	pxrd	pxrd	NOUN
admet-661	150	3	patterns	pattern	NOUN
admet-661	150	4	in	in	ADP
admet-661	150	5	fig	fig	NOUN
admet-661	150	6	.	.	PUNCT
admet-661	151	1	2	2	NUM
admet-661	151	2	showed	show	VERB
admet-661	151	3	characteristic	characteristic	ADJ
admet-661	151	4	peaks	peak	NOUN
admet-661	151	5	for	for	ADP
admet-661	151	6	ketoconazole	ketoconazole	NOUN
admet-661	151	7	cocrystals	cocrystal	NOUN
admet-661	151	8	and	and	CCONJ
admet-661	151	9	their	their	PRON
admet-661	151	10	parent	parent	NOUN
admet-661	151	11	materials	material	NOUN
admet-661	151	12	,	,	PUNCT
admet-661	151	13	indicating	indicate	VERB
admet-661	151	14	that	that	SCONJ
admet-661	151	15	the	the	DET
admet-661	151	16	cocrystals	cocrystal	NOUN
admet-661	151	17	are	be	AUX
admet-661	151	18	highly	highly	ADV
admet-661	151	19	crystalline	crystalline	ADJ
admet-661	151	20	.	.	PUNCT
admet-661	152	1	raman	raman	ADJ
admet-661	152	2	spectra	spectra	NOUN
admet-661	152	3	in	in	ADP
admet-661	152	4	fig	fig	NOUN
admet-661	152	5	.	.	PUNCT
admet-661	153	1	3	3	NUM
admet-661	153	2	also	also	ADV
admet-661	153	3	demonstrated	demonstrate	VERB
admet-661	153	4	that	that	SCONJ
admet-661	153	5	all	all	DET
admet-661	153	6	the	the	DET
admet-661	153	7	materials	material	NOUN
admet-661	153	8	have	have	VERB
admet-661	153	9	distinct	distinct	ADJ
admet-661	153	10	spectral	spectral	ADJ
admet-661	153	11	patterns	pattern	NOUN
admet-661	153	12	that	that	PRON
admet-661	153	13	are	be	AUX
admet-661	153	14	different	different	ADJ
admet-661	153	15	from	from	ADP
admet-661	153	16	each	each	DET
admet-661	153	17	other	other	ADJ
admet-661	153	18	.	.	PUNCT
admet-661	154	1	ketoconazole	ketoconazole	PROPN
admet-661	154	2	is	be	AUX
admet-661	154	3	a	a	DET
admet-661	154	4	weakly	weakly	ADJ
admet-661	154	5	basic	basic	ADJ
admet-661	154	6	drug	drug	NOUN
admet-661	154	7	having	have	VERB
admet-661	154	8	two	two	NUM
admet-661	154	9	pka	pka	PROPN
admet-661	154	10	values	value	NOUN
admet-661	154	11	of	of	ADP
admet-661	154	12	2.94	2.94	NUM
admet-661	154	13	and	and	CCONJ
admet-661	154	14	6.51	6.51	NUM
admet-661	155	1	[	[	X
admet-661	155	2	27	27	NUM
admet-661	155	3	]	]	PUNCT
admet-661	155	4	.	.	PUNCT
admet-661	156	1	it	it	PRON
admet-661	156	2	formed	form	VERB
admet-661	156	3	cocrystals	cocrystal	NOUN
admet-661	156	4	with	with	ADP
admet-661	156	5	weak	weak	ADJ
admet-661	156	6	organic	organic	ADJ
admet-661	156	7	acids	acid	NOUN
admet-661	156	8	such	such	ADJ
admet-661	156	9	as	as	ADP
admet-661	156	10	succinic	succinic	ADJ
admet-661	156	11	acid	acid	NOUN
admet-661	156	12	and	and	CCONJ
admet-661	156	13	fumaric	fumaric	ADJ
admet-661	156	14	acid	acid	PROPN
admet-661	156	15	.	.	PUNCT
admet-661	157	1	succinic	succinic	ADJ
admet-661	157	2	acid	acid	NOUN
admet-661	157	3	has	have	VERB
admet-661	157	4	pka	pka	PROPN
admet-661	157	5	values	value	NOUN
admet-661	157	6	of	of	ADP
admet-661	157	7	3.93	3.93	NUM
admet-661	157	8	and	and	CCONJ
admet-661	157	9	5.30	5.30	NUM
admet-661	157	10	for	for	ADP
admet-661	157	11	its	its	PRON
admet-661	157	12	first	first	ADJ
admet-661	157	13	and	and	CCONJ
admet-661	157	14	second	second	ADJ
admet-661	157	15	ionization	ionization	NOUN
admet-661	157	16	,	,	PUNCT
admet-661	157	17	respectively	respectively	ADV
admet-661	157	18	,	,	PUNCT
admet-661	157	19	while	while	SCONJ
admet-661	157	20	fumaric	fumaric	ADJ
admet-661	157	21	acid	acid	PROPN
admet-661	157	22	has	have	VERB
admet-661	157	23	pka	pka	PROPN
admet-661	157	24	values	value	NOUN
admet-661	157	25	of	of	ADP
admet-661	157	26	2.74	2.74	NUM
admet-661	157	27	and	and	CCONJ
admet-661	157	28	4.17	4.17	NUM
admet-661	157	29	for	for	ADP
admet-661	157	30	its	its	PRON
admet-661	157	31	first	first	ADJ
admet-661	157	32	and	and	CCONJ
admet-661	157	33	second	second	ADJ
admet-661	157	34	ionization	ionization	NOUN
admet-661	157	35	,	,	PUNCT
admet-661	157	36	respectively	respectively	ADV
admet-661	157	37	.	.	PUNCT
admet-661	158	1	childs	child	VERB
admet-661	158	2	et	et	PROPN
admet-661	158	3	al	al	PROPN
admet-661	158	4	.	.	PUNCT
admet-661	159	1	[	[	X
admet-661	159	2	36	36	NUM
admet-661	159	3	]	]	PUNCT
admet-661	159	4	postulated	postulate	VERB
admet-661	159	5	that	that	SCONJ
admet-661	159	6	a	a	DET
admet-661	159	7	pka	pka	PROPN
admet-661	159	8	difference	difference	NOUN
admet-661	159	9	of	of	ADP
admet-661	159	10	greater	great	ADJ
admet-661	159	11	than	than	ADP
admet-661	159	12	3	3	NUM
admet-661	159	13	between	between	ADP
admet-661	159	14	a	a	DET
admet-661	159	15	basic	basic	ADJ
admet-661	159	16	drug	drug	NOUN
admet-661	159	17	and	and	CCONJ
admet-661	159	18	its	its	PRON
admet-661	159	19	conjugate	conjugate	ADJ
admet-661	159	20	acid	acid	NOUN
admet-661	159	21	(	(	PUNCT
admet-661	159	22	∆pka	∆pka	NOUN
admet-661	159	23	>	>	SYM
admet-661	159	24	3	3	NUM
admet-661	159	25	)	)	PUNCT
admet-661	159	26	favors	favor	VERB
admet-661	159	27	salt	salt	NOUN
admet-661	159	28	formation	formation	NOUN
admet-661	159	29	rather	rather	ADV
admet-661	159	30	than	than	ADP
admet-661	159	31	cocrystals	cocrystal	NOUN
admet-661	159	32	,	,	PUNCT
admet-661	159	33	while	while	SCONJ
admet-661	159	34	the	the	DET
admet-661	159	35	cocrystal	cocrystal	ADJ
admet-661	159	36	formation	formation	NOUN
admet-661	159	37	is	be	AUX
admet-661	159	38	favored	favor	VERB
admet-661	159	39	when	when	SCONJ
admet-661	159	40	∆pka	∆pka	PROPN
admet-661	159	41	is	be	AUX
admet-661	159	42	<3	<3	NOUN
admet-661	159	43	.	.	PUNCT
admet-661	160	1	the	the	DET
admet-661	160	2	∆pka	∆pka	PROPN
admet-661	160	3	for	for	ADP
admet-661	160	4	ketoconazole	ketoconazole	NOUN
admet-661	160	5	and	and	CCONJ
admet-661	160	6	succinic	succinic	ADJ
admet-661	160	7	acid	acid	NOUN
admet-661	160	8	is	be	AUX
admet-661	160	9	<3	<3	X
admet-661	160	10	and	and	CCONJ
admet-661	160	11	,	,	PUNCT
admet-661	160	12	therefore	therefore	ADV
admet-661	160	13	,	,	PUNCT
admet-661	160	14	the	the	DET
admet-661	160	15	formation	formation	NOUN
admet-661	160	16	of	of	ADP
admet-661	160	17	cocrystal	cocrystal	NOUN
admet-661	160	18	was	be	AUX
admet-661	160	19	expected	expect	VERB
admet-661	160	20	.	.	PUNCT
admet-661	161	1	although	although	SCONJ
admet-661	161	2	the	the	DET
admet-661	161	3	pka	pka	PROPN
admet-661	161	4	difference	difference	NOUN
admet-661	161	5	between	between	ADP
admet-661	161	6	ketoconazole	ketoconazole	PROPN
admet-661	161	7	and	and	CCONJ
admet-661	161	8	fumaric	fumaric	ADJ
admet-661	161	9	acid	acid	PROPN
admet-661	161	10	is	be	AUX
admet-661	161	11	>	>	X
admet-661	161	12	3	3	NUM
admet-661	161	13	,	,	PUNCT
admet-661	161	14	a	a	DET
admet-661	161	15	cocrystal	cocrystal	NOUN
admet-661	161	16	,	,	PUNCT
admet-661	161	17	and	and	CCONJ
admet-661	161	18	no	no	DET
admet-661	161	19	salt	salt	NOUN
admet-661	161	20	,	,	PUNCT
admet-661	161	21	was	be	AUX
admet-661	161	22	formed	form	VERB
admet-661	161	23	.	.	PUNCT
admet-661	162	1	the	the	DET
admet-661	162	2	cocrystal	cocrystal	ADJ
admet-661	162	3	formation	formation	NOUN
admet-661	162	4	could	could	AUX
admet-661	162	5	be	be	AUX
admet-661	162	6	due	due	ADJ
admet-661	162	7	to	to	ADP
admet-661	162	8	hydrogen	hydrogen	NOUN
admet-661	162	9	bonding	bonding	NOUN
admet-661	162	10	between	between	ADP
admet-661	162	11	acetyl	acetyl	NOUN
admet-661	162	12	group	group	NOUN
admet-661	162	13	of	of	ADP
admet-661	162	14	ketoconazole	ketoconazole	NOUN
admet-661	162	15	and	and	CCONJ
admet-661	162	16	one	one	NUM
admet-661	162	17	of	of	ADP
admet-661	162	18	the	the	DET
admet-661	162	19	acid	acid	NOUN
admet-661	162	20	groups	group	NOUN
admet-661	162	21	in	in	ADP
admet-661	162	22	succinic	succinic	ADJ
admet-661	162	23	acid	acid	NOUN
admet-661	162	24	or	or	CCONJ
admet-661	162	25	fumaric	fumaric	ADJ
admet-661	162	26	acid	acid	NOUN
admet-661	162	27	.	.	PUNCT
admet-661	163	1	the	the	DET
admet-661	163	2	second	second	ADJ
admet-661	163	3	carboxyl	carboxyl	NOUN
admet-661	163	4	groups	group	NOUN
admet-661	163	5	in	in	ADP
admet-661	163	6	the	the	DET
admet-661	163	7	acids	acid	NOUN
admet-661	163	8	could	could	AUX
admet-661	163	9	also	also	ADV
admet-661	163	10	form	form	VERB
admet-661	163	11	hydrogen	hydrogen	NOUN
admet-661	163	12	bonds	bond	NOUN
admet-661	163	13	with	with	ADP
admet-661	163	14	imidazole	imidazole	NOUN
admet-661	163	15	n	n	CCONJ
admet-661	163	16	-	-	PUNCT
admet-661	163	17	atom	atom	NOUN
admet-661	163	18	of	of	ADP
admet-661	163	19	ketoconazole	ketoconazole	NOUN
admet-661	164	1	[	[	X
admet-661	164	2	28	28	NUM
admet-661	164	3	]	]	PUNCT
admet-661	164	4	.	.	PUNCT
admet-661	165	1	as	as	SCONJ
admet-661	165	2	reported	report	VERB
admet-661	165	3	by	by	ADP
admet-661	165	4	martin	martin	PROPN
admet-661	165	5	et	et	PROPN
admet-661	165	6	al	al	PROPN
admet-661	165	7	.	.	PUNCT
admet-661	166	1	[	[	X
admet-661	166	2	28	28	NUM
admet-661	166	3	]	]	PUNCT
admet-661	166	4	for	for	ADP
admet-661	166	5	ketoconazole	ketoconazole	NOUN
admet-661	166	6	-	-	PUNCT
admet-661	166	7	fumaric	fumaric	ADJ
admet-661	166	8	acid	acid	PROPN
admet-661	166	9	pair	pair	NOUN
admet-661	166	10	,	,	PUNCT
admet-661	166	11	hydrogen	hydrogen	NOUN
admet-661	166	12	bonding	bonding	NOUN
admet-661	166	13	is	be	AUX
admet-661	166	14	favored	favor	VERB
admet-661	166	15	instead	instead	ADV
admet-661	166	16	of	of	ADP
admet-661	166	17	proton	proton	NOUN
admet-661	166	18	transfer	transfer	NOUN
admet-661	166	19	due	due	ADP
admet-661	166	20	to	to	ADP
admet-661	166	21	spatial	spatial	ADJ
admet-661	166	22	crystal	crystal	NOUN
admet-661	166	23	environment	environment	NOUN
admet-661	166	24	in	in	ADP
admet-661	166	25	ketoconazole	ketoconazole	PROPN
admet-661	166	26	-	-	PUNCT
admet-661	166	27	fumaric	fumaric	ADJ
admet-661	166	28	acid	acid	NOUN
admet-661	166	29	cocrystals	cocrystal	NOUN
admet-661	166	30	.	.	PUNCT
admet-661	167	1	they	they	PRON
admet-661	167	2	also	also	ADV
admet-661	167	3	observed	observe	VERB
admet-661	167	4	that	that	SCONJ
admet-661	167	5	the	the	DET
admet-661	167	6	structure	structure	NOUN
admet-661	167	7	of	of	ADP
admet-661	167	8	ketoconazole	ketoconazole	NOUN
admet-661	167	9	-	-	PUNCT
admet-661	167	10	succinic	succinic	ADJ
admet-661	167	11	acid	acid	NOUN
admet-661	167	12	cocrystal	cocrystal	NOUN
admet-661	167	13	completely	completely	ADV
admet-661	167	14	resembles	resemble	VERB
admet-661	167	15	that	that	PRON
admet-661	167	16	of	of	ADP
admet-661	167	17	ketoconazole	ketoconazole	NOUN
admet-661	167	18	-	-	PUNCT
admet-661	167	19	fumaric	fumaric	ADJ
admet-661	167	20	acid	acid	PROPN
admet-661	167	21	cocrystal	cocrystal	PROPN
admet-661	167	22	.	.	PUNCT
admet-661	168	1	raman	raman	NOUN
admet-661	168	2	spectra	spectra	PROPN
admet-661	168	3	shown	show	VERB
admet-661	168	4	in	in	ADP
admet-661	168	5	fig	fig	NOUN
admet-661	168	6	.	.	PUNCT
admet-661	169	1	3	3	NUM
admet-661	169	2	also	also	ADV
admet-661	169	3	indicate	indicate	VERB
admet-661	169	4	cocrystal	cocrystal	ADJ
admet-661	169	5	formation	formation	NOUN
admet-661	169	6	.	.	PUNCT
admet-661	170	1	ketoconazole	ketoconazole	PROPN
admet-661	170	2	has	have	VERB
admet-661	170	3	a	a	DET
admet-661	170	4	characteristic	characteristic	ADJ
admet-661	170	5	peak	peak	NOUN
admet-661	170	6	at	at	ADP
admet-661	170	7	1640	1640	NUM
admet-661	170	8	cm-1	cm-1	NOUN
admet-661	170	9	for	for	ADP
admet-661	170	10	-c	-c	PROPN
admet-661	170	11	=	=	NOUN
admet-661	170	12	o	o	NOUN
admet-661	170	13	stretch	stretch	NOUN
admet-661	170	14	while	while	SCONJ
admet-661	170	15	raman	raman	NOUN
admet-661	170	16	spectra	spectra	NOUN
admet-661	170	17	of	of	ADP
admet-661	170	18	succinic	succinic	ADJ
admet-661	170	19	acid	acid	NOUN
admet-661	170	20	shows	show	VERB
admet-661	170	21	a	a	DET
admet-661	170	22	peak	peak	NOUN
admet-661	170	23	at	at	ADP
admet-661	170	24	1650	1650	NUM
admet-661	170	25	cm-1	cm-1	NOUN
admet-661	170	26	for	for	ADP
admet-661	170	27	-c=0	-c=0	PRON
admet-661	170	28	(	(	PUNCT
admet-661	170	29	carbonyl	carbonyl	NOUN
admet-661	170	30	group	group	NOUN
admet-661	170	31	)	)	PUNCT
admet-661	170	32	of	of	ADP
admet-661	170	33	acid	acid	PROPN
admet-661	171	1	[	[	X
admet-661	171	2	37,38	37,38	NOUN
admet-661	171	3	]	]	PUNCT
admet-661	171	4	.	.	PUNCT
admet-661	172	1	in	in	ADP
admet-661	172	2	the	the	DET
admet-661	172	3	ketoconazole	ketoconazole	NOUN
admet-661	172	4	-	-	PUNCT
admet-661	172	5	succinic	succinic	ADJ
admet-661	172	6	acid	acid	NOUN
admet-661	172	7	cocrystal	cocrystal	PROPN
admet-661	172	8	spectrum	spectrum	NOUN
admet-661	172	9	,	,	PUNCT
admet-661	172	10	the	the	DET
admet-661	172	11	-c	-c	PROPN
admet-661	172	12	=	=	NOUN
admet-661	172	13	o	o	NOUN
admet-661	172	14	peak	peak	NOUN
admet-661	172	15	shifts	shift	NOUN
admet-661	172	16	to	to	ADP
admet-661	172	17	1724	1724	NUM
admet-661	172	18	cm-1	cm-1	NOUN
admet-661	172	19	because	because	SCONJ
admet-661	172	20	of	of	ADP
admet-661	172	21	hydrogen	hydrogen	NOUN
admet-661	172	22	bond	bond	NOUN
admet-661	172	23	formation	formation	NOUN
admet-661	172	24	between	between	ADP
admet-661	172	25	one	one	NUM
admet-661	172	26	of	of	ADP
admet-661	172	27	the	the	DET
admet-661	172	28	carboxylic	carboxylic	ADJ
admet-661	172	29	acid	acid	NOUN
admet-661	172	30	groups	group	NOUN
admet-661	172	31	of	of	ADP
admet-661	172	32	succinic	succinic	ADJ
admet-661	172	33	acid	acid	NOUN
admet-661	172	34	and	and	CCONJ
admet-661	172	35	the	the	DET
admet-661	172	36	-c	-c	PROPN
admet-661	172	37	=	=	PROPN
admet-661	172	38	o	o	NOUN
admet-661	172	39	group	group	NOUN
admet-661	172	40	of	of	ADP
admet-661	172	41	ketoconazole	ketoconazole	PROPN
admet-661	172	42	.	.	PUNCT
admet-661	173	1	this	this	DET
admet-661	173	2	change	change	NOUN
admet-661	173	3	in	in	ADP
admet-661	173	4	raman	raman	NOUN
admet-661	173	5	spectrum	spectrum	NOUN
admet-661	173	6	of	of	ADP
admet-661	173	7	ketoconazole	ketoconazole	NOUN
admet-661	173	8	-	-	PUNCT
admet-661	173	9	succinic	succinic	ADJ
admet-661	173	10	acid	acid	NOUN
admet-661	173	11	cocrystal	cocrystal	NOUN
admet-661	173	12	shows	show	VERB
admet-661	173	13	the	the	DET
admet-661	173	14	formation	formation	NOUN
admet-661	173	15	of	of	ADP
admet-661	173	16	hydrogen	hydrogen	NOUN
admet-661	173	17	bond	bond	NOUN
admet-661	173	18	.	.	PUNCT
admet-661	174	1	in	in	ADP
admet-661	174	2	this	this	DET
admet-661	174	3	cocrystal	cocrystal	NOUN
admet-661	174	4	,	,	PUNCT
admet-661	174	5	one	one	NUM
admet-661	174	6	more	more	ADJ
admet-661	174	7	hydrogen	hydrogen	NOUN
admet-661	174	8	bond	bond	NOUN
admet-661	174	9	formation	formation	NOUN
admet-661	174	10	occurs	occur	VERB
admet-661	174	11	between	between	ADP
admet-661	174	12	the	the	DET
admet-661	174	13	second	second	ADJ
admet-661	174	14	carboxyl	carboxyl	NOUN
admet-661	174	15	group	group	NOUN
admet-661	174	16	of	of	ADP
admet-661	174	17	succinic	succinic	ADJ
admet-661	174	18	acid	acid	NOUN
admet-661	174	19	and	and	CCONJ
admet-661	174	20	nitrogen	nitrogen	NOUN
admet-661	174	21	of	of	ADP
admet-661	174	22	imidazole	imidazole	NOUN
admet-661	174	23	group	group	NOUN
admet-661	174	24	of	of	ADP
admet-661	174	25	ketoconazole	ketoconazole	PROPN
admet-661	174	26	.	.	PUNCT
admet-661	175	1	due	due	ADP
admet-661	175	2	to	to	ADP
admet-661	175	3	the	the	DET
admet-661	175	4	participation	participation	NOUN
admet-661	175	5	of	of	ADP
admet-661	175	6	nitrogen	nitrogen	NOUN
admet-661	175	7	of	of	ADP
admet-661	175	8	imidazole	imidazole	NOUN
admet-661	175	9	(	(	PUNCT
admet-661	175	10	ketoconazole	ketoconazole	NOUN
admet-661	175	11	)	)	PUNCT
admet-661	175	12	in	in	ADP
admet-661	175	13	hydrogen	hydrogen	NOUN
admet-661	175	14	bond	bond	NOUN
admet-661	175	15	formation	formation	NOUN
admet-661	175	16	,	,	PUNCT
admet-661	175	17	a	a	DET
admet-661	175	18	shift	shift	NOUN
admet-661	175	19	in	in	ADP
admet-661	175	20	n	n	CCONJ
admet-661	175	21	=	=	SYM
admet-661	175	22	c	c	X
admet-661	175	23	—	—	PUNCT
admet-661	175	24	h	h	NOUN
admet-661	175	25	stretch	stretch	NOUN
admet-661	175	26	from	from	ADP
admet-661	175	27	3113	3113	NUM
admet-661	175	28	cm-1	cm-1	PUNCT
admet-661	175	29	to	to	ADP
admet-661	175	30	3131	3131	NUM
admet-661	175	31	cm-1	cm-1	VERB
admet-661	176	1	could	could	AUX
admet-661	176	2	be	be	AUX
admet-661	176	3	observed	observe	VERB
admet-661	176	4	in	in	ADP
admet-661	176	5	the	the	DET
admet-661	176	6	cocrystal	cocrystal	NOUN
admet-661	176	7	as	as	SCONJ
admet-661	176	8	compared	compare	VERB
admet-661	176	9	to	to	ADP
admet-661	176	10	the	the	DET
admet-661	176	11	ketoconazole	ketoconazole	PROPN
admet-661	176	12	spectrum	spectrum	NOUN
admet-661	176	13	.	.	PUNCT
admet-661	177	1	in	in	ADP
admet-661	177	2	the	the	DET
admet-661	177	3	ketoconazole	ketoconazole	NOUN
admet-661	177	4	-	-	PUNCT
admet-661	177	5	succinic	succinic	ADJ
admet-661	177	6	acid	acid	NOUN
admet-661	177	7	cocrystal	cocrystal	NOUN
admet-661	177	8	,	,	PUNCT
admet-661	177	9	the	the	DET
admet-661	177	10	four	four	NUM
admet-661	177	11	-	-	PUNCT
admet-661	177	12	member	member	NOUN
admet-661	177	13	ring	ring	NOUN
admet-661	177	14	formation	formation	NOUN
admet-661	177	15	involving	involve	VERB
admet-661	177	16	two	two	NUM
admet-661	177	17	ketoconazole	ketoconazole	NOUN
admet-661	177	18	and	and	CCONJ
admet-661	177	19	two	two	NUM
admet-661	177	20	succinic	succinic	ADJ
admet-661	177	21	acid	acid	NOUN
admet-661	177	22	moieties	moiety	NOUN
admet-661	177	23	was	be	AUX
admet-661	177	24	observed	observe	VERB
admet-661	177	25	[	[	X
admet-661	177	26	28	28	NUM
admet-661	177	27	]	]	PUNCT
admet-661	177	28	,	,	PUNCT
admet-661	177	29	which	which	PRON
admet-661	177	30	is	be	AUX
admet-661	177	31	supported	support	VERB
admet-661	177	32	by	by	ADP
admet-661	177	33	two	two	NUM
admet-661	177	34	hydrogen	hydrogen	NOUN
admet-661	177	35	bonds	bond	NOUN
admet-661	177	36	linking	link	VERB
admet-661	177	37	all	all	DET
admet-661	177	38	four	four	NUM
admet-661	177	39	molecules	molecule	NOUN
admet-661	177	40	in	in	ADP
admet-661	177	41	a	a	DET
admet-661	177	42	circuit	circuit	NOUN
admet-661	177	43	network	network	NOUN
admet-661	177	44	.	.	PUNCT
admet-661	178	1	vasoya	vasoya	PROPN
admet-661	178	2	et	et	PROPN
admet-661	178	3	al	al	PROPN
admet-661	178	4	.	.	PROPN
admet-661	178	5	admet	admet	PROPN
admet-661	178	6	&	&	CCONJ
admet-661	178	7	dmpk	dmpk	PROPN
admet-661	178	8	7(2	7(2	NUM
admet-661	178	9	)	)	PUNCT
admet-661	178	10	(	(	PUNCT
admet-661	178	11	2019	2019	NUM
admet-661	178	12	)	)	PUNCT
admet-661	178	13	106	106	NUM
admet-661	178	14	-	-	SYM
admet-661	178	15	130	130	NUM
admet-661	178	16	114	114	NUM
admet-661	178	17	figure	figure	NOUN
admet-661	178	18	1	1	NUM
admet-661	178	19	.	.	PUNCT
admet-661	178	20	comparative	comparative	ADJ
admet-661	178	21	dsc	dsc	NOUN
admet-661	178	22	scans	scan	NOUN
admet-661	178	23	of	of	ADP
admet-661	178	24	ketoconazole	ketoconazole	NOUN
admet-661	178	25	,	,	PUNCT
admet-661	178	26	succinic	succinic	ADJ
admet-661	178	27	acid	acid	NOUN
admet-661	178	28	,	,	PUNCT
admet-661	178	29	fumaric	fumaric	ADJ
admet-661	178	30	acid	acid	NOUN
admet-661	178	31	,	,	PUNCT
admet-661	178	32	and	and	CCONJ
admet-661	178	33	ketoconazole	ketoconazole	PROPN
admet-661	178	34	cocrystals	cocrystal	NOUN
admet-661	178	35	with	with	ADP
admet-661	178	36	fumaric	fumaric	ADJ
admet-661	178	37	acid	acid	PROPN
admet-661	178	38	and	and	CCONJ
admet-661	178	39	succinic	succinic	ADJ
admet-661	178	40	acid	acid	NOUN
admet-661	178	41	.	.	PUNCT
admet-661	179	1	figure	figure	NOUN
admet-661	179	2	2	2	NUM
admet-661	179	3	.	.	PUNCT
admet-661	179	4	comparative	comparative	ADJ
admet-661	179	5	powder	powder	NOUN
admet-661	179	6	x	x	NOUN
admet-661	179	7	-	-	NOUN
admet-661	179	8	ray	ray	NOUN
admet-661	179	9	patterns	pattern	NOUN
admet-661	179	10	of	of	ADP
admet-661	179	11	ketoconazole	ketoconazole	NOUN
admet-661	179	12	,	,	PUNCT
admet-661	179	13	succinic	succinic	ADJ
admet-661	179	14	acid	acid	NOUN
admet-661	179	15	,	,	PUNCT
admet-661	179	16	fumaric	fumaric	ADJ
admet-661	179	17	acid	acid	NOUN
admet-661	179	18	,	,	PUNCT
admet-661	179	19	and	and	CCONJ
admet-661	179	20	ketoconazole	ketoconazole	PROPN
admet-661	179	21	cocrystals	cocrystal	NOUN
admet-661	179	22	with	with	ADP
admet-661	179	23	fumaric	fumaric	ADJ
admet-661	179	24	acid	acid	PROPN
admet-661	179	25	and	and	CCONJ
admet-661	179	26	succinic	succinic	ADJ
admet-661	179	27	acid	acid	NOUN
admet-661	179	28	.	.	PUNCT
admet-661	180	1	similarly	similarly	ADV
admet-661	180	2	,	,	PUNCT
admet-661	180	3	raman	raman	NOUN
admet-661	180	4	spectrum	spectrum	NOUN
admet-661	180	5	of	of	ADP
admet-661	180	6	fumaric	fumaric	ADJ
admet-661	180	7	acid	acid	PROPN
admet-661	180	8	shows	show	VERB
admet-661	180	9	peak	peak	NOUN
admet-661	180	10	at	at	ADP
admet-661	180	11	1682	1682	NUM
admet-661	180	12	cm-1	cm-1	X
admet-661	180	13	for	for	ADP
admet-661	180	14	the	the	DET
admet-661	180	15	carboxylic	carboxylic	ADJ
admet-661	180	16	acid	acid	NOUN
admet-661	180	17	group	group	NOUN
admet-661	180	18	that	that	SCONJ
admet-661	180	19	shifts	shift	NOUN
admet-661	180	20	towards	towards	ADP
admet-661	180	21	a	a	DET
admet-661	180	22	higher	high	ADJ
admet-661	180	23	wave	wave	NOUN
admet-661	180	24	number	number	NOUN
admet-661	180	25	of	of	ADP
admet-661	180	26	1718	1718	NUM
admet-661	180	27	cm-1	cm-1	X
admet-661	180	28	due	due	ADP
admet-661	180	29	to	to	ADP
admet-661	180	30	hydrogen	hydrogen	NOUN
admet-661	180	31	bonding	bonding	NOUN
admet-661	180	32	with	with	ADP
admet-661	180	33	-c	-c	PROPN
admet-661	180	34	=	=	NOUN
admet-661	180	35	o	o	NOUN
admet-661	180	36	group	group	NOUN
admet-661	180	37	of	of	ADP
admet-661	180	38	ketoconazole	ketoconazole	NOUN
admet-661	180	39	in	in	ADP
admet-661	180	40	the	the	DET
admet-661	180	41	cocrystal	cocrystal	NOUN
admet-661	180	42	.	.	PUNCT
admet-661	181	1	the	the	DET
admet-661	181	2	ketoconazole	ketoconazole	NOUN
admet-661	181	3	-c	-c	PROPN
admet-661	181	4	=	=	NOUN
admet-661	181	5	o	o	NOUN
admet-661	181	6	peak	peak	NOUN
admet-661	181	7	shifts	shift	NOUN
admet-661	181	8	from	from	ADP
admet-661	181	9	1640	1640	NUM
admet-661	181	10	cm-1	cm-1	NOUN
admet-661	181	11	to	to	ADP
admet-661	181	12	1665	1665	NUM
admet-661	181	13	cm-1	cm-1	NOUN
admet-661	181	14	due	due	ADP
admet-661	181	15	to	to	ADP
admet-661	181	16	hydrogen	hydrogen	NOUN
admet-661	181	17	bond	bond	NOUN
admet-661	181	18	formation	formation	NOUN
admet-661	181	19	with	with	ADP
admet-661	181	20	the	the	DET
admet-661	181	21	cocrystal	cocrystal	NOUN
admet-661	181	22	.	.	PUNCT
admet-661	182	1	also	also	ADV
admet-661	182	2	,	,	PUNCT
admet-661	182	3	a	a	DET
admet-661	182	4	hydrogen	hydrogen	NOUN
admet-661	182	5	bond	bond	NOUN
admet-661	182	6	is	be	AUX
admet-661	182	7	formed	form	VERB
admet-661	182	8	between	between	ADP
admet-661	182	9	the	the	DET
admet-661	182	10	second	second	ADJ
admet-661	182	11	carboxylic	carboxylic	ADJ
admet-661	182	12	acid	acid	NOUN
admet-661	182	13	group	group	NOUN
admet-661	182	14	of	of	ADP
admet-661	182	15	fumaric	fumaric	PROPN
admet-661	182	16	acid	acid	PROPN
admet-661	182	17	and	and	CCONJ
admet-661	182	18	nitrogen	nitrogen	NOUN
admet-661	182	19	of	of	ADP
admet-661	182	20	imidazole	imidazole	NOUN
admet-661	182	21	group	group	NOUN
admet-661	182	22	in	in	ADP
admet-661	182	23	ketoconazole	ketoconazole	PROPN
admet-661	182	24	.	.	PUNCT
admet-661	183	1	thus	thus	ADV
admet-661	183	2	,	,	PUNCT
admet-661	183	3	ketoconazoleadmet	ketoconazoleadmet	PROPN
admet-661	183	4	&	&	CCONJ
admet-661	183	5	dmpk	dmpk	PROPN
admet-661	183	6	7(2	7(2	NOUN
admet-661	183	7	)	)	PUNCT
admet-661	183	8	(	(	PUNCT
admet-661	183	9	2019	2019	NUM
admet-661	183	10	)	)	PUNCT
admet-661	183	11	106	106	NUM
admet-661	183	12	-	-	SYM
admet-661	183	13	130	130	NUM
admet-661	183	14	solubility	solubility	NOUN
admet-661	183	15	and	and	CCONJ
admet-661	183	16	dissolution	dissolution	NOUN
admet-661	183	17	of	of	ADP
admet-661	183	18	cocrystals	cocrystal	NOUN
admet-661	183	19	doi	doi	NOUN
admet-661	183	20	:	:	PUNCT
admet-661	183	21	10.5599	10.5599	NUM
admet-661	183	22	/	/	SYM
admet-661	183	23	admet.661	admet.661	PROPN
admet-661	183	24	115	115	NUM
admet-661	183	25	fumaric	fumaric	ADJ
admet-661	183	26	acid	acid	NOUN
admet-661	183	27	cocrystal	cocrystal	PROPN
admet-661	183	28	forms	form	VERB
admet-661	183	29	a	a	DET
admet-661	183	30	similar	similar	ADJ
admet-661	183	31	4	4	NUM
admet-661	183	32	-	-	PUNCT
admet-661	183	33	member	member	NOUN
admet-661	183	34	ring	ring	NOUN
admet-661	183	35	structure	structure	NOUN
admet-661	183	36	as	as	ADP
admet-661	183	37	that	that	PRON
admet-661	183	38	of	of	ADP
admet-661	183	39	the	the	DET
admet-661	183	40	ketoconazole	ketoconazole	NOUN
admet-661	183	41	-	-	PUNCT
admet-661	183	42	succinic	succinic	ADJ
admet-661	183	43	acid	acid	NOUN
admet-661	183	44	cocrystal	cocrystal	NOUN
admet-661	183	45	.	.	PUNCT
admet-661	184	1	figure	figure	VERB
admet-661	184	2	3	3	NUM
admet-661	184	3	.	.	PUNCT
admet-661	184	4	comparative	comparative	ADJ
admet-661	184	5	raman	raman	NOUN
admet-661	184	6	spectral	spectral	ADJ
admet-661	184	7	scans	scan	NOUN
admet-661	184	8	of	of	ADP
admet-661	184	9	ketoconazole	ketoconazole	NOUN
admet-661	184	10	,	,	PUNCT
admet-661	184	11	succinic	succinic	ADJ
admet-661	184	12	acid	acid	NOUN
admet-661	184	13	,	,	PUNCT
admet-661	184	14	fumaric	fumaric	ADJ
admet-661	184	15	acid	acid	NOUN
admet-661	184	16	,	,	PUNCT
admet-661	184	17	and	and	CCONJ
admet-661	184	18	ketoconazole	ketoconazole	PROPN
admet-661	184	19	cocrystals	cocrystal	NOUN
admet-661	184	20	with	with	ADP
admet-661	184	21	fumaric	fumaric	ADJ
admet-661	184	22	acid	acid	PROPN
admet-661	184	23	and	and	CCONJ
admet-661	184	24	succinic	succinic	ADJ
admet-661	184	25	acid	acid	NOUN
admet-661	184	26	.	.	PUNCT
admet-661	185	1	ph	ph	PROPN
admet-661	185	2	versus	versus	ADP
admet-661	185	3	solubility	solubility	NOUN
admet-661	185	4	of	of	ADP
admet-661	185	5	ketoconazole	ketoconazole	PROPN
admet-661	185	6	base	base	NOUN
admet-661	185	7	for	for	ADP
admet-661	185	8	a	a	DET
admet-661	185	9	comparison	comparison	NOUN
admet-661	185	10	of	of	ADP
admet-661	185	11	solubility	solubility	NOUN
admet-661	185	12	of	of	ADP
admet-661	185	13	the	the	DET
admet-661	185	14	basic	basic	ADJ
admet-661	185	15	drug	drug	NOUN
admet-661	185	16	,	,	PUNCT
admet-661	185	17	ketoconazole	ketoconazole	NOUN
admet-661	185	18	,	,	PUNCT
admet-661	185	19	with	with	ADP
admet-661	185	20	that	that	PRON
admet-661	185	21	of	of	ADP
admet-661	185	22	cocrystals	cocrystal	NOUN
admet-661	185	23	,	,	PUNCT
admet-661	185	24	the	the	DET
admet-661	185	25	ph	ph	VERB
admet-661	185	26	-	-	PUNCT
admet-661	185	27	solubility	solubility	NOUN
admet-661	185	28	profile	profile	NOUN
admet-661	185	29	of	of	ADP
admet-661	185	30	ketoconazole	ketoconazole	NOUN
admet-661	185	31	was	be	AUX
admet-661	185	32	determined	determine	VERB
admet-661	185	33	using	use	VERB
admet-661	185	34	hcl	hcl	PROPN
admet-661	185	35	to	to	PART
admet-661	185	36	adjust	adjust	VERB
admet-661	185	37	ph	ph	ADJ
admet-661	185	38	.	.	PUNCT
admet-661	186	1	the	the	DET
admet-661	186	2	results	result	NOUN
admet-661	186	3	are	be	AUX
admet-661	186	4	tabulated	tabulate	VERB
admet-661	186	5	in	in	ADP
admet-661	186	6	table	table	NOUN
admet-661	186	7	1	1	NUM
admet-661	186	8	,	,	PUNCT
admet-661	186	9	and	and	CCONJ
admet-661	186	10	they	they	PRON
admet-661	186	11	are	be	AUX
admet-661	186	12	also	also	ADV
admet-661	186	13	plotted	plot	VERB
admet-661	186	14	in	in	ADP
admet-661	186	15	fig	fig	NOUN
admet-661	186	16	.	.	PUNCT
admet-661	187	1	4	4	NUM
admet-661	187	2	for	for	ADP
admet-661	187	3	visual	visual	ADJ
admet-661	187	4	observation	observation	NOUN
admet-661	187	5	of	of	ADP
admet-661	187	6	the	the	DET
admet-661	187	7	nature	nature	NOUN
admet-661	187	8	of	of	ADP
admet-661	187	9	change	change	NOUN
admet-661	187	10	in	in	ADP
admet-661	187	11	solubility	solubility	NOUN
admet-661	187	12	as	as	ADP
admet-661	187	13	a	a	DET
admet-661	187	14	function	function	NOUN
admet-661	187	15	of	of	ADP
admet-661	187	16	ph	ph	PROPN
admet-661	187	17	.	.	PUNCT
admet-661	188	1	the	the	DET
admet-661	188	2	intrinsic	intrinsic	ADJ
admet-661	188	3	solubility	solubility	NOUN
admet-661	188	4	of	of	ADP
admet-661	188	5	the	the	DET
admet-661	188	6	ketoconazole	ketoconazole	NOUN
admet-661	188	7	free	free	ADJ
admet-661	188	8	base	base	NOUN
admet-661	188	9	,	,	PUNCT
admet-661	188	10	i.e.	i.e.	X
admet-661	188	11	,	,	PUNCT
admet-661	188	12	the	the	DET
admet-661	188	13	solubility	solubility	NOUN
admet-661	188	14	of	of	ADP
admet-661	188	15	the	the	DET
admet-661	188	16	nonprotonated	nonprotonate	VERB
admet-661	188	17	species	specie	NOUN
admet-661	188	18	,	,	PUNCT
admet-661	188	19	at	at	ADP
admet-661	188	20	ph	ph	NOUN
admet-661	188	21	higher	high	ADJ
admet-661	188	22	than	than	ADP
admet-661	188	23	8	8	NUM
admet-661	188	24	was	be	AUX
admet-661	188	25	found	find	VERB
admet-661	188	26	to	to	PART
admet-661	188	27	be	be	AUX
admet-661	188	28	around	around	ADV
admet-661	188	29	2	2	NUM
admet-661	188	30	µg	µg	NOUN
admet-661	188	31	/	/	SYM
admet-661	188	32	ml	ml	NOUN
admet-661	188	33	,	,	PUNCT
admet-661	188	34	and	and	CCONJ
admet-661	188	35	the	the	DET
admet-661	188	36	solubility	solubility	NOUN
admet-661	188	37	increased	increase	VERB
admet-661	188	38	exponentially	exponentially	ADV
admet-661	188	39	as	as	SCONJ
admet-661	188	40	the	the	DET
admet-661	188	41	ph	ph	NOUN
admet-661	188	42	was	be	AUX
admet-661	188	43	decreased	decrease	VERB
admet-661	188	44	gradually	gradually	ADV
admet-661	188	45	in	in	ADP
admet-661	188	46	the	the	DET
admet-661	188	47	range	range	NOUN
admet-661	188	48	of	of	ADP
admet-661	188	49	approximately	approximately	ADV
admet-661	188	50	5.5	5.5	NUM
admet-661	188	51	and	and	CCONJ
admet-661	188	52	3	3	NUM
admet-661	188	53	,	,	PUNCT
admet-661	188	54	as	as	SCONJ
admet-661	188	55	indicated	indicate	VERB
admet-661	188	56	by	by	ADP
admet-661	188	57	the	the	DET
admet-661	188	58	linearity	linearity	NOUN
admet-661	188	59	of	of	ADP
admet-661	188	60	the	the	DET
admet-661	188	61	semilogarithmic	semilogarithmic	ADJ
admet-661	188	62	plot	plot	NOUN
admet-661	188	63	in	in	ADP
admet-661	188	64	fig	fig	NOUN
admet-661	188	65	.	.	PUNCT
admet-661	189	1	4	4	X
admet-661	189	2	.	.	X
admet-661	189	3	the	the	DET
admet-661	189	4	highest	high	ADJ
admet-661	189	5	solubility	solubility	NOUN
admet-661	189	6	of	of	ADP
admet-661	189	7	148.3	148.3	NUM
admet-661	189	8	mg	mg	NOUN
admet-661	189	9	/	/	SYM
admet-661	189	10	ml	ml	AUX
admet-661	189	11	(	(	PUNCT
admet-661	189	12	not	not	PART
admet-661	189	13	shown	show	VERB
admet-661	189	14	in	in	ADP
admet-661	189	15	figure	figure	NOUN
admet-661	189	16	)	)	PUNCT
admet-661	189	17	for	for	ADP
admet-661	189	18	ketoconazole	ketoconazole	NOUN
admet-661	189	19	at	at	ADP
admet-661	189	20	ph	ph	PROPN
admet-661	189	21	3.1	3.1	NUM
admet-661	189	22	was	be	AUX
admet-661	189	23	measured	measure	VERB
admet-661	189	24	in	in	ADP
admet-661	189	25	the	the	DET
admet-661	189	26	present	present	ADJ
admet-661	189	27	study	study	NOUN
admet-661	189	28	,	,	PUNCT
admet-661	189	29	when	when	SCONJ
admet-661	189	30	the	the	DET
admet-661	189	31	solution	solution	NOUN
admet-661	189	32	turned	turn	VERB
admet-661	189	33	orange	orange	ADJ
admet-661	189	34	.	.	PUNCT
admet-661	190	1	any	any	DET
admet-661	190	2	further	further	ADJ
admet-661	190	3	reduction	reduction	NOUN
admet-661	190	4	in	in	ADP
admet-661	190	5	ph	ph	NOUN
admet-661	190	6	to	to	PART
admet-661	190	7	increase	increase	VERB
admet-661	190	8	solubility	solubility	NOUN
admet-661	190	9	by	by	ADP
admet-661	190	10	still	still	ADV
admet-661	190	11	keeping	keep	VERB
admet-661	190	12	the	the	DET
admet-661	190	13	solution	solution	NOUN
admet-661	190	14	in	in	ADP
admet-661	190	15	equilibrium	equilibrium	NOUN
admet-661	190	16	with	with	ADP
admet-661	190	17	a	a	DET
admet-661	190	18	solid	solid	ADJ
admet-661	190	19	phase	phase	NOUN
admet-661	190	20	was	be	AUX
admet-661	190	21	not	not	PART
admet-661	190	22	possible	possible	ADJ
admet-661	190	23	;	;	PUNCT
admet-661	190	24	the	the	DET
admet-661	190	25	added	add	VERB
admet-661	190	26	ketoconazole	ketoconazole	NOUN
admet-661	190	27	dissolved	dissolve	VERB
admet-661	190	28	if	if	SCONJ
admet-661	190	29	the	the	DET
admet-661	190	30	ph	ph	NOUN
admet-661	190	31	was	be	AUX
admet-661	190	32	decreased	decrease	VERB
admet-661	190	33	by	by	ADP
admet-661	190	34	adding	add	VERB
admet-661	190	35	concentrated	concentrate	VERB
admet-661	190	36	hcl	hcl	PROPN
admet-661	190	37	and	and	CCONJ
admet-661	190	38	the	the	DET
admet-661	190	39	ph	ph	NOUN
admet-661	190	40	went	go	VERB
admet-661	190	41	back	back	ADV
admet-661	190	42	to	to	ADP
admet-661	190	43	around	around	ADP
admet-661	190	44	3	3	NUM
admet-661	190	45	when	when	SCONJ
admet-661	190	46	more	more	ADV
admet-661	190	47	solid	solid	ADJ
admet-661	190	48	ketoconazole	ketoconazole	NOUN
admet-661	190	49	was	be	AUX
admet-661	190	50	added	add	VERB
admet-661	190	51	to	to	ADP
admet-661	190	52	the	the	DET
admet-661	190	53	solution	solution	NOUN
admet-661	190	54	.	.	PUNCT
admet-661	191	1	although	although	SCONJ
admet-661	191	2	there	there	PRON
admet-661	191	3	is	be	VERB
admet-661	191	4	a	a	DET
admet-661	191	5	report	report	NOUN
admet-661	191	6	that	that	SCONJ
admet-661	191	7	the	the	DET
admet-661	191	8	preparation	preparation	NOUN
admet-661	191	9	of	of	ADP
admet-661	191	10	ketoconazole	ketoconazole	PROPN
admet-661	191	11	dihydrochloride	dihydrochloride	NOUN
admet-661	191	12	salt	salt	NOUN
admet-661	191	13	having	have	VERB
admet-661	191	14	very	very	ADV
admet-661	191	15	high	high	ADJ
admet-661	191	16	solubility	solubility	NOUN
admet-661	191	17	and	and	CCONJ
admet-661	191	18	the	the	DET
admet-661	191	19	melting	melting	NOUN
admet-661	191	20	point	point	NOUN
admet-661	191	21	of	of	ADP
admet-661	191	22	229	229	NUM
admet-661	191	23	°	°	NOUN
admet-661	191	24	c	c	NOUN
admet-661	191	25	is	be	AUX
admet-661	191	26	feasible	feasible	ADJ
admet-661	191	27	[	[	PUNCT
admet-661	191	28	39	39	NUM
admet-661	191	29	]	]	PUNCT
admet-661	191	30	,	,	PUNCT
admet-661	191	31	neither	neither	CCONJ
admet-661	191	32	the	the	DET
admet-661	191	33	monohydrochloride	monohydrochloride	NOUN
admet-661	191	34	salt	salt	NOUN
admet-661	191	35	nor	nor	CCONJ
admet-661	191	36	the	the	DET
admet-661	191	37	dihydrochloride	dihydrochloride	NOUN
admet-661	191	38	salt	salt	NOUN
admet-661	191	39	precipitated	precipitate	VERB
admet-661	191	40	out	out	ADP
admet-661	191	41	during	during	ADP
admet-661	191	42	the	the	DET
admet-661	191	43	ph	ph	VERB
admet-661	191	44	-	-	PUNCT
admet-661	191	45	solubility	solubility	NOUN
admet-661	191	46	study	study	NOUN
admet-661	191	47	in	in	ADP
admet-661	191	48	the	the	DET
admet-661	191	49	present	present	ADJ
admet-661	191	50	investigation	investigation	NOUN
admet-661	191	51	.	.	PUNCT
admet-661	192	1	attempts	attempt	VERB
admet-661	192	2	to	to	PART
admet-661	192	3	crystallize	crystallize	VERB
admet-661	192	4	ketoconazole	ketoconazole	NOUN
admet-661	192	5	hydrochloride	hydrochloride	NOUN
admet-661	192	6	salts	salt	NOUN
admet-661	192	7	from	from	ADP
admet-661	192	8	anhydrous	anhydrous	ADJ
admet-661	192	9	methanolic	methanolic	NOUN
admet-661	192	10	solutions	solution	NOUN
admet-661	192	11	in	in	ADP
admet-661	192	12	separate	separate	ADJ
admet-661	192	13	studies	study	NOUN
admet-661	192	14	were	be	AUX
admet-661	192	15	also	also	ADV
admet-661	192	16	negative	negative	ADJ
admet-661	192	17	as	as	SCONJ
admet-661	192	18	they	they	PRON
admet-661	192	19	yielded	yield	VERB
admet-661	192	20	amorphous	amorphous	ADJ
admet-661	192	21	materials	material	NOUN
admet-661	192	22	.	.	PUNCT
admet-661	193	1	vasoya	vasoya	PROPN
admet-661	193	2	et	et	PROPN
admet-661	193	3	al	al	PROPN
admet-661	193	4	.	.	PROPN
admet-661	193	5	admet	admet	PROPN
admet-661	193	6	&	&	CCONJ
admet-661	193	7	dmpk	dmpk	PROPN
admet-661	193	8	7(2	7(2	NUM
admet-661	193	9	)	)	PUNCT
admet-661	193	10	(	(	PUNCT
admet-661	193	11	2019	2019	NUM
admet-661	193	12	)	)	PUNCT
admet-661	193	13	106	106	NUM
admet-661	193	14	-	-	SYM
admet-661	193	15	130	130	NUM
admet-661	193	16	116	116	NUM
admet-661	193	17	table	table	NOUN
admet-661	193	18	1	1	NUM
admet-661	193	19	equilibrium	equilibrium	NOUN
admet-661	193	20	solubility	solubility	NOUN
admet-661	193	21	of	of	ADP
admet-661	193	22	ketoconazole	ketoconazole	PROPN
admet-661	193	23	base	base	NOUN
admet-661	193	24	at	at	ADP
admet-661	193	25	different	different	ADJ
admet-661	193	26	ph	ph	NOUN
admet-661	193	27	at	at	ADP
admet-661	193	28	25	25	NUM
admet-661	193	29	°	°	NOUN
admet-661	193	30	c	c	NOUN
admet-661	193	31	,	,	PUNCT
admet-661	193	32	where	where	SCONJ
admet-661	193	33	ph	ph	NOUN
admet-661	193	34	of	of	ADP
admet-661	193	35	aqueous	aqueous	ADJ
admet-661	193	36	suspensions	suspension	NOUN
admet-661	193	37	was	be	AUX
admet-661	193	38	lowered	lower	VERB
admet-661	193	39	using	use	VERB
admet-661	193	40	hcl	hcl	PROPN
admet-661	193	41	solutions	solution	NOUN
admet-661	193	42	.	.	PUNCT
admet-661	194	1	ph	ph	ADJ
admet-661	194	2	and	and	CCONJ
admet-661	194	3	corresponding	corresponding	ADJ
admet-661	194	4	solubilities	solubility	NOUN
admet-661	194	5	from	from	ADP
admet-661	194	6	individual	individual	ADJ
admet-661	194	7	vials	vial	NOUN
admet-661	194	8	,	,	PUNCT
admet-661	194	9	including	include	VERB
admet-661	194	10	repeating	repeat	VERB
admet-661	194	11	observations	observation	NOUN
admet-661	194	12	,	,	PUNCT
admet-661	194	13	are	be	AUX
admet-661	194	14	shown	show	VERB
admet-661	194	15	.	.	PUNCT
admet-661	195	1	ph	ph	NOUN
admet-661	195	2	of	of	ADP
admet-661	195	3	suspension	suspension	NOUN
admet-661	195	4	solubility	solubility	NOUN
admet-661	195	5	(	(	PUNCT
admet-661	195	6	μg	μg	NOUN
admet-661	195	7	/	/	SYM
admet-661	195	8	ml	ml	NOUN
admet-661	195	9	)	)	PUNCT
admet-661	195	10	ph	ph	NOUN
admet-661	195	11	of	of	ADP
admet-661	195	12	suspension	suspension	NOUN
admet-661	195	13	solubility	solubility	NOUN
admet-661	195	14	(	(	PUNCT
admet-661	195	15	μg	μg	NOUN
admet-661	195	16	/	/	SYM
admet-661	195	17	ml	ml	NOUN
admet-661	195	18	)	)	PUNCT
admet-661	195	19	ph	ph	NOUN
admet-661	195	20	of	of	ADP
admet-661	195	21	suspension	suspension	NOUN
admet-661	195	22	solubility	solubility	NOUN
admet-661	195	23	(	(	PUNCT
admet-661	195	24	μg	μg	NOUN
admet-661	195	25	/	/	SYM
admet-661	195	26	ml	ml	NOUN
admet-661	195	27	)	)	PUNCT
admet-661	195	28	3.1	3.1	NUM
admet-661	195	29	148320	148320	NUM
admet-661	195	30	4.28	4.28	NUM
admet-661	195	31	729	729	NUM
admet-661	195	32	7.23	7.23	NUM
admet-661	195	33	4	4	NUM
admet-661	195	34	3.35	3.35	NUM
admet-661	195	35	5457	5457	NUM
admet-661	195	36	4.48	4.48	NUM
admet-661	195	37	345	345	NUM
admet-661	195	38	7.23	7.23	NUM
admet-661	195	39	4	4	NUM
admet-661	195	40	3.35	3.35	NUM
admet-661	195	41	5429	5429	NUM
admet-661	195	42	4.56	4.56	NUM
admet-661	195	43	354	354	NUM
admet-661	195	44	7.27	7.27	NUM
admet-661	195	45	3	3	NUM
admet-661	195	46	3.37	3.37	NUM
admet-661	195	47	7100	7100	NUM
admet-661	195	48	4.56	4.56	NUM
admet-661	195	49	354	354	NUM
admet-661	195	50	7.72	7.72	NUM
admet-661	195	51	2	2	NUM
admet-661	195	52	3.58	3.58	NUM
admet-661	195	53	3425	3425	NUM
admet-661	195	54	4.95	4.95	NUM
admet-661	195	55	178	178	NUM
admet-661	195	56	7.92	7.92	NUM
admet-661	195	57	3	3	NUM
admet-661	195	58	3.67	3.67	NUM
admet-661	195	59	3031	3031	NUM
admet-661	195	60	4.99	4.99	NUM
admet-661	195	61	175	175	NUM
admet-661	195	62	8.49	8.49	NUM
admet-661	195	63	2	2	NUM
admet-661	195	64	3.71	3.71	NUM
admet-661	195	65	2782	2782	NUM
admet-661	195	66	4.99	4.99	NUM
admet-661	195	67	175	175	NUM
admet-661	195	68	3.81	3.81	NUM
admet-661	195	69	1931	1931	NUM
admet-661	195	70	7.12	7.12	NUM
admet-661	195	71	5	5	NUM
admet-661	195	72	as	as	SCONJ
admet-661	195	73	mentioned	mention	VERB
admet-661	195	74	earlier	early	ADV
admet-661	195	75	,	,	PUNCT
admet-661	195	76	ketoconazole	ketoconazole	PROPN
admet-661	195	77	has	have	VERB
admet-661	195	78	two	two	NUM
admet-661	195	79	pka	pka	PROPN
admet-661	195	80	values	value	NOUN
admet-661	195	81	of	of	ADP
admet-661	195	82	2.94	2.94	NUM
admet-661	195	83	and	and	CCONJ
admet-661	195	84	6.51	6.51	NUM
admet-661	195	85	,	,	PUNCT
admet-661	195	86	and	and	CCONJ
admet-661	195	87	the	the	DET
admet-661	195	88	increase	increase	NOUN
admet-661	195	89	in	in	ADP
admet-661	195	90	solubility	solubility	NOUN
admet-661	195	91	of	of	ADP
admet-661	195	92	the	the	DET
admet-661	195	93	compound	compound	NOUN
admet-661	195	94	plotted	plot	VERB
admet-661	195	95	in	in	ADP
admet-661	195	96	fig	fig	NOUN
admet-661	195	97	.	.	PUNCT
admet-661	196	1	4	4	NUM
admet-661	196	2	is	be	AUX
admet-661	196	3	obviously	obviously	ADV
admet-661	196	4	due	due	ADJ
admet-661	196	5	to	to	ADP
admet-661	196	6	the	the	DET
admet-661	196	7	effect	effect	NOUN
admet-661	196	8	of	of	ADP
admet-661	196	9	the	the	DET
admet-661	196	10	pka	pka	NOUN
admet-661	196	11	of	of	ADP
admet-661	196	12	6.51	6.51	NUM
admet-661	196	13	,	,	PUNCT
admet-661	196	14	since	since	SCONJ
admet-661	196	15	any	any	DET
admet-661	196	16	significant	significant	ADJ
admet-661	196	17	effect	effect	NOUN
admet-661	196	18	of	of	ADP
admet-661	196	19	the	the	DET
admet-661	196	20	pka	pka	NOUN
admet-661	196	21	of	of	ADP
admet-661	196	22	2.94	2.94	NUM
admet-661	196	23	may	may	AUX
admet-661	196	24	not	not	PART
admet-661	196	25	be	be	AUX
admet-661	196	26	observed	observe	VERB
admet-661	196	27	in	in	ADP
admet-661	196	28	the	the	DET
admet-661	196	29	ph	ph	ADJ
admet-661	196	30	range	range	NOUN
admet-661	196	31	studied	study	VERB
admet-661	196	32	.	.	PUNCT
admet-661	197	1	therefore	therefore	ADV
admet-661	197	2	,	,	PUNCT
admet-661	197	3	the	the	DET
admet-661	197	4	solubility	solubility	NOUN
admet-661	197	5	data	datum	NOUN
admet-661	197	6	are	be	AUX
admet-661	197	7	plotted	plot	VERB
admet-661	197	8	in	in	ADP
admet-661	197	9	the	the	DET
admet-661	197	10	figure	figure	NOUN
admet-661	197	11	according	accord	VERB
admet-661	197	12	to	to	ADP
admet-661	197	13	the	the	DET
admet-661	197	14	equation	equation	NOUN
admet-661	197	15	(	(	PUNCT
admet-661	197	16	1	1	NUM
admet-661	197	17	)	)	PUNCT
admet-661	197	18	,	,	PUNCT
admet-661	197	19	where	where	SCONJ
admet-661	197	20	st	st	PROPN
admet-661	197	21	is	be	AUX
admet-661	197	22	the	the	DET
admet-661	197	23	total	total	ADJ
admet-661	197	24	solubility	solubility	NOUN
admet-661	197	25	at	at	ADP
admet-661	197	26	a	a	DET
admet-661	197	27	particular	particular	ADJ
admet-661	197	28	ph	ph	NOUN
admet-661	197	29	and	and	CCONJ
admet-661	197	30	[	[	X
admet-661	197	31	b]s	b]s	NOUN
admet-661	197	32	is	be	AUX
admet-661	197	33	the	the	DET
admet-661	197	34	intrinsic	intrinsic	ADJ
admet-661	197	35	solubility	solubility	NOUN
admet-661	197	36	of	of	ADP
admet-661	197	37	the	the	DET
admet-661	197	38	free	free	ADJ
admet-661	197	39	base	base	NOUN
admet-661	197	40	[	[	X
admet-661	197	41	31	31	NUM
admet-661	197	42	]	]	PUNCT
admet-661	197	43	,	,	PUNCT
admet-661	197	44	which	which	PRON
admet-661	197	45	in	in	ADP
admet-661	197	46	case	case	NOUN
admet-661	197	47	of	of	ADP
admet-661	197	48	ketoconazole	ketoconazole	NOUN
admet-661	197	49	was	be	AUX
admet-661	197	50	taken	take	VERB
admet-661	197	51	as	as	ADP
admet-661	197	52	2	2	NUM
admet-661	197	53	µg	µg	ADV
admet-661	197	54	/	/	SYM
admet-661	197	55	ml	ml	NOUN
admet-661	197	56	.	.	PUNCT
admet-661	198	1	𝑆𝑇,𝑏𝑎𝑠𝑒(𝑝𝐻	𝑆𝑇,𝑏𝑎𝑠𝑒(𝑝𝐻	NOUN
admet-661	198	2	>	>	X
admet-661	198	3	𝑝𝐻𝑚𝑎𝑥	𝑝𝐻𝑚𝑎𝑥	PROPN
admet-661	198	4	)	)	PUNCT
admet-661	198	5	=	=	PUNCT
admet-661	199	1	[	[	X
admet-661	199	2	𝐵]𝑠	𝐵]𝑠	PROPN
admet-661	199	3	(	(	PUNCT
admet-661	199	4	1	1	NUM
admet-661	199	5	+	+	CCONJ
admet-661	200	1	[	[	X
admet-661	200	2	𝐻3𝑂+	𝐻3𝑂+	X
admet-661	200	3	]	]	X
admet-661	200	4	𝐾𝑎	𝐾𝑎	NOUN
admet-661	200	5	)	)	PUNCT
admet-661	200	6	=	=	PUNCT
admet-661	201	1	[	[	X
admet-661	201	2	𝐵]𝑠	𝐵]𝑠	PROPN
admet-661	201	3	(	(	PUNCT
admet-661	201	4	1	1	NUM
admet-661	201	5	+	+	SYM
admet-661	201	6	10𝑝𝐾𝑎−𝑝𝐻	10𝑝𝐾𝑎−𝑝𝐻	NUM
admet-661	201	7	)	)	PUNCT
admet-661	201	8	(	(	PUNCT
admet-661	201	9	1	1	X
admet-661	201	10	)	)	PUNCT
admet-661	201	11	the	the	DET
admet-661	201	12	linearity	linearity	NOUN
admet-661	201	13	of	of	ADP
admet-661	201	14	the	the	DET
admet-661	201	15	semi	semi	ADJ
admet-661	201	16	-	-	ADJ
admet-661	201	17	logarithmic	logarithmic	ADJ
admet-661	201	18	plot	plot	NOUN
admet-661	201	19	of	of	ADP
admet-661	201	20	solubility	solubility	NOUN
admet-661	201	21	as	as	ADP
admet-661	201	22	a	a	DET
admet-661	201	23	function	function	NOUN
admet-661	201	24	of	of	ADP
admet-661	201	25	ph	ph	NOUN
admet-661	201	26	in	in	ADP
admet-661	201	27	the	the	DET
admet-661	201	28	ph	ph	ADJ
admet-661	201	29	range	range	NOUN
admet-661	201	30	of	of	ADP
admet-661	201	31	~6.0	~6.0	NOUN
admet-661	201	32	to	to	PART
admet-661	201	33	~3.5	~3.5	PUNCT
admet-661	201	34	showed	show	VERB
admet-661	201	35	that	that	SCONJ
admet-661	201	36	the	the	DET
admet-661	201	37	increase	increase	NOUN
admet-661	201	38	in	in	ADP
admet-661	201	39	solubility	solubility	NOUN
admet-661	201	40	follows	follow	VERB
admet-661	201	41	the	the	DET
admet-661	201	42	classic	classic	ADJ
admet-661	201	43	henderson	henderson	PROPN
admet-661	201	44	-	-	PUNCT
admet-661	201	45	hasselbalch	hasselbalch	PROPN
admet-661	201	46	equation	equation	NOUN
admet-661	201	47	.	.	PUNCT
admet-661	202	1	there	there	PRON
admet-661	202	2	was	be	VERB
admet-661	202	3	no	no	DET
admet-661	202	4	deviation	deviation	NOUN
admet-661	202	5	from	from	ADP
admet-661	202	6	the	the	DET
admet-661	202	7	linearity	linearity	NOUN
admet-661	202	8	of	of	ADP
admet-661	202	9	the	the	DET
admet-661	202	10	graph	graph	NOUN
admet-661	202	11	until	until	SCONJ
admet-661	202	12	the	the	DET
admet-661	202	13	ph	ph	NOUN
admet-661	202	14	decreased	decrease	VERB
admet-661	202	15	below	below	ADP
admet-661	202	16	3.5	3.5	NUM
admet-661	202	17	since	since	SCONJ
admet-661	202	18	there	there	PRON
admet-661	202	19	was	be	VERB
admet-661	202	20	no	no	DET
admet-661	202	21	effect	effect	NOUN
admet-661	202	22	of	of	ADP
admet-661	202	23	the	the	DET
admet-661	202	24	second	second	ADJ
admet-661	202	25	pka	pka	PROPN
admet-661	202	26	value	value	NOUN
admet-661	202	27	on	on	ADP
admet-661	202	28	the	the	DET
admet-661	202	29	solubility	solubility	NOUN
admet-661	202	30	of	of	ADP
admet-661	202	31	ketoconazole	ketoconazole	NOUN
admet-661	202	32	at	at	ADP
admet-661	202	33	higher	high	ADJ
admet-661	202	34	ph	ph	PROPN
admet-661	202	35	.	.	PUNCT
admet-661	203	1	the	the	DET
admet-661	203	2	nonlinear	nonlinear	ADJ
admet-661	203	3	increase	increase	NOUN
admet-661	203	4	in	in	ADP
admet-661	203	5	solubility	solubility	NOUN
admet-661	203	6	around	around	ADP
admet-661	203	7	ph	ph	PROPN
admet-661	203	8	3	3	NUM
admet-661	203	9	in	in	ADP
admet-661	203	10	the	the	DET
admet-661	203	11	semi	semi	ADJ
admet-661	203	12	-	-	ADJ
admet-661	203	13	logarithmic	logarithmic	ADJ
admet-661	203	14	plot	plot	NOUN
admet-661	203	15	could	could	AUX
admet-661	203	16	be	be	AUX
admet-661	203	17	due	due	ADJ
admet-661	203	18	to	to	ADP
admet-661	203	19	second	second	ADJ
admet-661	203	20	protonation	protonation	NOUN
admet-661	203	21	of	of	ADP
admet-661	203	22	the	the	DET
admet-661	203	23	molecule	molecule	NOUN
admet-661	203	24	because	because	SCONJ
admet-661	203	25	of	of	ADP
admet-661	203	26	the	the	DET
admet-661	203	27	effect	effect	NOUN
admet-661	203	28	of	of	ADP
admet-661	203	29	the	the	DET
admet-661	203	30	second	second	ADJ
admet-661	203	31	pka	pka	PROPN
admet-661	203	32	value	value	NOUN
admet-661	203	33	.	.	PUNCT
admet-661	204	1	ph	ph	PROPN
admet-661	204	2	versus	versus	ADP
admet-661	204	3	solubility	solubility	NOUN
admet-661	204	4	of	of	ADP
admet-661	204	5	ketoconazole	ketoconazole	PROPN
admet-661	204	6	cocrystals	cocrystal	VERB
admet-661	204	7	the	the	DET
admet-661	204	8	solubility	solubility	NOUN
admet-661	204	9	of	of	ADP
admet-661	204	10	ketoconazole	ketoconazole	PROPN
admet-661	204	11	cocrystal	cocrystal	PROPN
admet-661	204	12	as	as	ADP
admet-661	204	13	a	a	DET
admet-661	204	14	function	function	NOUN
admet-661	204	15	of	of	ADP
admet-661	204	16	ph	ph	NOUN
admet-661	204	17	was	be	AUX
admet-661	204	18	determined	determine	VERB
admet-661	204	19	by	by	ADP
admet-661	204	20	adjusting	adjust	VERB
admet-661	204	21	the	the	DET
admet-661	204	22	ph	ph	NOUN
admet-661	204	23	of	of	ADP
admet-661	204	24	a	a	DET
admet-661	204	25	saturated	saturate	VERB
admet-661	204	26	solution	solution	NOUN
admet-661	204	27	of	of	ADP
admet-661	204	28	cocrystal	cocrystal	NOUN
admet-661	204	29	to	to	ADP
admet-661	204	30	a	a	DET
admet-661	204	31	lower	low	ADJ
admet-661	204	32	ph	ph	NOUN
admet-661	204	33	by	by	ADP
admet-661	204	34	adding	add	VERB
admet-661	204	35	aqueous	aqueous	ADJ
admet-661	204	36	solutions	solution	NOUN
admet-661	204	37	of	of	ADP
admet-661	204	38	respective	respective	ADJ
admet-661	204	39	coformer	coformer	NOUN
admet-661	204	40	and	and	CCONJ
admet-661	204	41	to	to	ADP
admet-661	204	42	a	a	DET
admet-661	204	43	higher	high	ADJ
admet-661	204	44	ph	ph	NOUN
admet-661	204	45	by	by	ADP
admet-661	204	46	adding	add	VERB
admet-661	204	47	naoh	naoh	ADJ
admet-661	204	48	aqueous	aqueous	ADJ
admet-661	204	49	solutions	solution	NOUN
admet-661	204	50	.	.	PUNCT
admet-661	205	1	the	the	DET
admet-661	205	2	results	result	NOUN
admet-661	205	3	are	be	AUX
admet-661	205	4	plotted	plot	VERB
admet-661	205	5	in	in	ADP
admet-661	205	6	fig	fig	NOUN
admet-661	205	7	.	.	PUNCT
admet-661	206	1	5	5	NUM
admet-661	206	2	.	.	X
admet-661	206	3	when	when	SCONJ
admet-661	206	4	excess	excess	ADJ
admet-661	206	5	amounts	amount	NOUN
admet-661	206	6	of	of	ADP
admet-661	206	7	fumaric	fumaric	ADJ
admet-661	206	8	acid	acid	PROPN
admet-661	206	9	and	and	CCONJ
admet-661	206	10	succinic	succinic	ADJ
admet-661	206	11	acid	acid	NOUN
admet-661	206	12	cocrystals	cocrystal	NOUN
admet-661	206	13	were	be	AUX
admet-661	206	14	dissolved	dissolve	VERB
admet-661	206	15	in	in	ADP
admet-661	206	16	water	water	NOUN
admet-661	206	17	,	,	PUNCT
admet-661	206	18	ph	ph	ADJ
admet-661	206	19	values	value	NOUN
admet-661	206	20	of	of	ADP
admet-661	206	21	the	the	DET
admet-661	206	22	saturated	saturate	VERB
admet-661	206	23	solutions	solution	NOUN
admet-661	206	24	were	be	AUX
admet-661	206	25	,	,	PUNCT
admet-661	206	26	respectively	respectively	ADV
admet-661	206	27	,	,	PUNCT
admet-661	206	28	4.1	4.1	NUM
admet-661	206	29	and	and	CCONJ
admet-661	206	30	4.2	4.2	NUM
admet-661	206	31	,	,	PUNCT
admet-661	206	32	and	and	CCONJ
admet-661	206	33	the	the	DET
admet-661	206	34	solubilities	solubility	NOUN
admet-661	206	35	of	of	ADP
admet-661	206	36	cocrystals	cocrystal	NOUN
admet-661	206	37	were	be	AUX
admet-661	206	38	,	,	PUNCT
admet-661	206	39	respectively	respectively	ADV
admet-661	206	40	,	,	PUNCT
admet-661	206	41	2.6	2.6	NUM
admet-661	206	42	and	and	CCONJ
admet-661	206	43	1.5	1.5	NUM
admet-661	206	44	mg	mg	NUM
admet-661	206	45	/	/	SYM
admet-661	206	46	ml	ml	PROPN
admet-661	207	1	(	(	PUNCT
admet-661	207	2	as	as	ADP
admet-661	207	3	ketoconazole	ketoconazole	PROPN
admet-661	207	4	equivalents	equivalent	NOUN
admet-661	207	5	)	)	PUNCT
admet-661	207	6	.	.	PUNCT
admet-661	208	1	as	as	SCONJ
admet-661	208	2	examined	examine	VERB
admet-661	208	3	by	by	ADP
admet-661	208	4	dsc	dsc	NOUN
admet-661	208	5	and	and	CCONJ
admet-661	208	6	pxrd	pxrd	PROPN
admet-661	208	7	analyses	analysis	NOUN
admet-661	208	8	,	,	PUNCT
admet-661	208	9	the	the	DET
admet-661	208	10	solid	solid	ADJ
admet-661	208	11	phases	phase	NOUN
admet-661	208	12	in	in	ADP
admet-661	208	13	equilibria	equilibrium	NOUN
admet-661	208	14	with	with	ADP
admet-661	208	15	these	these	DET
admet-661	208	16	cocrystal	cocrystal	ADJ
admet-661	208	17	solutions	solution	NOUN
admet-661	208	18	in	in	ADP
admet-661	208	19	water	water	NOUN
admet-661	208	20	were	be	AUX
admet-661	208	21	mixtures	mixture	NOUN
admet-661	208	22	of	of	ADP
admet-661	208	23	cocrystals	cocrystal	NOUN
admet-661	208	24	and	and	CCONJ
admet-661	208	25	free	free	ADJ
admet-661	208	26	base	base	NOUN
admet-661	208	27	,	,	PUNCT
admet-661	208	28	the	the	DET
admet-661	208	29	fraction	fraction	NOUN
admet-661	208	30	of	of	ADP
admet-661	208	31	free	free	ADJ
admet-661	208	32	base	base	NOUN
admet-661	208	33	being	be	AUX
admet-661	208	34	relatively	relatively	ADV
admet-661	208	35	very	very	ADV
admet-661	208	36	small	small	ADJ
admet-661	208	37	in	in	ADP
admet-661	208	38	the	the	DET
admet-661	208	39	total	total	NOUN
admet-661	208	40	solid	solid	NOUN
admet-661	208	41	.	.	PUNCT
admet-661	209	1	as	as	SCONJ
admet-661	209	2	shown	show	VERB
admet-661	209	3	in	in	ADP
admet-661	209	4	fig	fig	NOUN
admet-661	209	5	.	.	PUNCT
admet-661	210	1	5	5	NUM
admet-661	210	2	,	,	PUNCT
admet-661	210	3	when	when	SCONJ
admet-661	210	4	ph	ph	ADJ
admet-661	210	5	values	value	NOUN
admet-661	210	6	of	of	ADP
admet-661	210	7	cocrystal	cocrystal	ADJ
admet-661	210	8	solutions	solution	NOUN
admet-661	210	9	in	in	ADP
admet-661	210	10	water	water	NOUN
admet-661	210	11	were	be	AUX
admet-661	210	12	lowered	lower	VERB
admet-661	210	13	by	by	ADP
admet-661	210	14	adding	add	VERB
admet-661	210	15	respective	respective	ADJ
admet-661	210	16	acidic	acidic	ADJ
admet-661	210	17	coformers	coformer	NOUN
admet-661	210	18	,	,	PUNCT
admet-661	210	19	there	there	PRON
admet-661	210	20	were	be	VERB
admet-661	210	21	initial	initial	ADJ
admet-661	210	22	decreases	decrease	NOUN
admet-661	210	23	in	in	ADP
admet-661	210	24	solubility	solubility	NOUN
admet-661	210	25	,	,	PUNCT
admet-661	210	26	which	which	PRON
admet-661	210	27	then	then	ADV
admet-661	210	28	increased	increase	VERB
admet-661	210	29	with	with	ADP
admet-661	210	30	continued	continued	ADJ
admet-661	210	31	addition	addition	NOUN
admet-661	210	32	of	of	ADP
admet-661	210	33	coformer	coformer	NOUN
admet-661	210	34	solutions	solution	NOUN
admet-661	210	35	to	to	PART
admet-661	210	36	further	far	ADV
admet-661	210	37	decrease	decrease	VERB
admet-661	210	38	ph	ph	PROPN
admet-661	210	39	.	.	PUNCT
admet-661	211	1	the	the	DET
admet-661	211	2	solid	solid	ADJ
admet-661	211	3	phases	phase	NOUN
admet-661	211	4	in	in	ADP
admet-661	211	5	equilibria	equilibrium	NOUN
admet-661	211	6	with	with	ADP
admet-661	211	7	these	these	DET
admet-661	211	8	solutions	solution	NOUN
admet-661	211	9	were	be	AUX
admet-661	211	10	only	only	ADV
admet-661	211	11	cocrystals	cocrystal	NOUN
admet-661	211	12	since	since	SCONJ
admet-661	211	13	no	no	DET
admet-661	211	14	conversion	conversion	NOUN
admet-661	211	15	to	to	ADP
admet-661	211	16	free	free	ADJ
admet-661	211	17	base	base	NOUN
admet-661	211	18	occurred	occur	VERB
admet-661	211	19	when	when	SCONJ
admet-661	211	20	excess	excess	ADJ
admet-661	211	21	coformer	coformer	NOUN
admet-661	211	22	was	be	AUX
admet-661	211	23	added	add	VERB
admet-661	211	24	.	.	PUNCT
admet-661	212	1	the	the	DET
admet-661	212	2	mechanism	mechanism	NOUN
admet-661	212	3	of	of	ADP
admet-661	212	4	the	the	DET
admet-661	212	5	decrease	decrease	NOUN
admet-661	212	6	in	in	ADP
admet-661	212	7	solubility	solubility	NOUN
admet-661	212	8	that	that	PRON
admet-661	212	9	was	be	AUX
admet-661	212	10	followed	follow	VERB
admet-661	212	11	by	by	ADP
admet-661	212	12	the	the	DET
admet-661	212	13	increase	increase	NOUN
admet-661	212	14	has	have	VERB
admet-661	212	15	admet	admet	PROPN
admet-661	212	16	&	&	CCONJ
admet-661	212	17	dmpk	dmpk	PROPN
admet-661	212	18	7(2	7(2	NUM
admet-661	212	19	)	)	PUNCT
admet-661	212	20	(	(	PUNCT
admet-661	212	21	2019	2019	NUM
admet-661	212	22	)	)	PUNCT
admet-661	212	23	106	106	NUM
admet-661	212	24	-	-	SYM
admet-661	212	25	130	130	NUM
admet-661	212	26	solubility	solubility	NOUN
admet-661	212	27	and	and	CCONJ
admet-661	212	28	dissolution	dissolution	NOUN
admet-661	212	29	of	of	ADP
admet-661	212	30	cocrystals	cocrystal	NOUN
admet-661	212	31	doi	doi	NOUN
admet-661	212	32	:	:	PUNCT
admet-661	212	33	10.5599	10.5599	NUM
admet-661	212	34	/	/	SYM
admet-661	212	35	admet.661	admet.661	PROPN
admet-661	212	36	117	117	NUM
admet-661	212	37	not	not	PART
admet-661	212	38	been	be	AUX
admet-661	212	39	elucidated	elucidate	VERB
admet-661	212	40	.	.	PUNCT
admet-661	213	1	it	it	PRON
admet-661	213	2	is	be	AUX
admet-661	213	3	possible	possible	ADJ
admet-661	213	4	that	that	SCONJ
admet-661	213	5	some	some	DET
admet-661	213	6	forms	form	NOUN
admet-661	213	7	of	of	ADP
admet-661	213	8	complexes	complex	NOUN
admet-661	213	9	may	may	AUX
admet-661	213	10	exist	exist	VERB
admet-661	213	11	between	between	ADP
admet-661	213	12	ketoconazole	ketoconazole	NOUN
admet-661	213	13	and	and	CCONJ
admet-661	213	14	coformers	coformer	NOUN
admet-661	213	15	in	in	ADP
admet-661	213	16	solution	solution	NOUN
admet-661	213	17	in	in	ADP
admet-661	213	18	this	this	DET
admet-661	213	19	ph	ph	ADJ
admet-661	213	20	range	range	NOUN
admet-661	213	21	and	and	CCONJ
admet-661	213	22	the	the	DET
admet-661	213	23	solubility	solubility	NOUN
admet-661	213	24	profiles	profile	NOUN
admet-661	213	25	reflect	reflect	VERB
admet-661	213	26	the	the	DET
admet-661	213	27	change	change	NOUN
admet-661	213	28	in	in	ADP
admet-661	213	29	nature	nature	NOUN
admet-661	213	30	and	and	CCONJ
admet-661	213	31	solubility	solubility	NOUN
admet-661	213	32	of	of	ADP
admet-661	213	33	such	such	ADJ
admet-661	213	34	complexes	complex	NOUN
admet-661	213	35	.	.	PUNCT
admet-661	214	1	figure	figure	NOUN
admet-661	214	2	4	4	NUM
admet-661	214	3	.	.	PUNCT
admet-661	214	4	ketoconazole	ketoconazole	PROPN
admet-661	214	5	ph	ph	VERB
admet-661	214	6	-	-	PUNCT
admet-661	214	7	solubility	solubility	NOUN
admet-661	214	8	profile	profile	NOUN
admet-661	214	9	generated	generate	VERB
admet-661	214	10	by	by	ADP
admet-661	214	11	using	use	VERB
admet-661	214	12	hydrochloric	hydrochloric	ADJ
admet-661	214	13	acid	acid	NOUN
admet-661	214	14	to	to	PART
admet-661	214	15	adjust	adjust	VERB
admet-661	214	16	ph	ph	PROPN
admet-661	214	17	.	.	PROPN
admet-661	214	18	when	when	SCONJ
admet-661	214	19	ph	ph	ADJ
admet-661	214	20	values	value	NOUN
admet-661	214	21	of	of	ADP
admet-661	214	22	the	the	DET
admet-661	214	23	saturated	saturate	VERB
admet-661	214	24	solutions	solution	NOUN
admet-661	214	25	of	of	ADP
admet-661	214	26	ketoconazole	ketoconazole	PROPN
admet-661	214	27	cocrystals	cocrystal	NOUN
admet-661	214	28	with	with	ADP
admet-661	214	29	fumaric	fumaric	ADJ
admet-661	214	30	acid	acid	PROPN
admet-661	214	31	and	and	CCONJ
admet-661	214	32	succinic	succinic	ADJ
admet-661	214	33	acid	acid	NOUN
admet-661	214	34	were	be	AUX
admet-661	214	35	increased	increase	VERB
admet-661	214	36	by	by	ADP
admet-661	214	37	adding	add	VERB
admet-661	214	38	naoh	naoh	NOUN
admet-661	214	39	solutions	solution	NOUN
admet-661	214	40	,	,	PUNCT
admet-661	214	41	the	the	DET
admet-661	214	42	solubility	solubility	NOUN
admet-661	214	43	decreased	decrease	VERB
admet-661	214	44	for	for	ADP
admet-661	214	45	both	both	DET
admet-661	214	46	cocrystals	cocrystal	NOUN
admet-661	214	47	.	.	PUNCT
admet-661	215	1	the	the	DET
admet-661	215	2	ph	ph	PROPN
admet-661	215	3	versus	versus	ADP
admet-661	215	4	solubility	solubility	NOUN
admet-661	215	5	of	of	ADP
admet-661	215	6	ketoconazole	ketoconazole	PROPN
admet-661	215	7	free	free	ADJ
admet-661	215	8	base	base	NOUN
admet-661	215	9	,	,	PUNCT
admet-661	215	10	which	which	PRON
admet-661	215	11	was	be	AUX
admet-661	215	12	generated	generate	VERB
admet-661	215	13	by	by	ADP
admet-661	215	14	the	the	DET
admet-661	215	15	adjustment	adjustment	NOUN
admet-661	215	16	of	of	ADP
admet-661	215	17	ph	ph	NOUN
admet-661	215	18	using	use	VERB
admet-661	215	19	hcl	hcl	PROPN
admet-661	215	20	or	or	CCONJ
admet-661	215	21	naoh	naoh	NOUN
admet-661	215	22	,	,	PUNCT
admet-661	215	23	is	be	AUX
admet-661	215	24	also	also	ADV
admet-661	215	25	plotted	plot	VERB
admet-661	215	26	in	in	ADP
admet-661	215	27	fig	fig	NOUN
admet-661	215	28	.	.	PUNCT
admet-661	216	1	5	5	X
admet-661	216	2	.	.	X
admet-661	216	3	a	a	DET
admet-661	216	4	comparison	comparison	NOUN
admet-661	216	5	of	of	ADP
admet-661	216	6	the	the	DET
admet-661	216	7	three	three	NUM
admet-661	216	8	plots	plot	NOUN
admet-661	216	9	show	show	VERB
admet-661	216	10	that	that	SCONJ
admet-661	216	11	the	the	DET
admet-661	216	12	solubility	solubility	NOUN
admet-661	216	13	of	of	ADP
admet-661	216	14	the	the	DET
admet-661	216	15	free	free	ADJ
admet-661	216	16	base	base	NOUN
admet-661	216	17	and	and	CCONJ
admet-661	216	18	the	the	DET
admet-661	216	19	two	two	NUM
admet-661	216	20	cocrystals	cocrystal	NOUN
admet-661	216	21	were	be	AUX
admet-661	216	22	identical	identical	ADJ
admet-661	216	23	at	at	ADP
admet-661	216	24	ph>4.1	ph>4.1	X
admet-661	216	25	.	.	NOUN
admet-661	216	26	solid	solid	ADJ
admet-661	216	27	phases	phase	NOUN
admet-661	216	28	in	in	ADP
admet-661	216	29	equilibria	equilibrium	NOUN
admet-661	216	30	with	with	ADP
admet-661	216	31	solutions	solution	NOUN
admet-661	216	32	during	during	ADP
admet-661	216	33	the	the	DET
admet-661	216	34	determination	determination	NOUN
admet-661	216	35	of	of	ADP
admet-661	216	36	ph	ph	ADJ
admet-661	216	37	-	-	PUNCT
admet-661	216	38	solubility	solubility	NOUN
admet-661	216	39	profiles	profile	NOUN
admet-661	216	40	under	under	ADP
admet-661	216	41	these	these	DET
admet-661	216	42	ph	ph	ADJ
admet-661	216	43	conditions	condition	NOUN
admet-661	216	44	were	be	AUX
admet-661	216	45	mixtures	mixture	NOUN
admet-661	216	46	of	of	ADP
admet-661	216	47	ketoconazole	ketoconazole	NOUN
admet-661	216	48	free	free	ADJ
admet-661	216	49	base	base	NOUN
admet-661	216	50	and	and	CCONJ
admet-661	216	51	cocrystals	cocrystal	NOUN
admet-661	216	52	,	,	PUNCT
admet-661	216	53	and	and	CCONJ
admet-661	216	54	only	only	ADV
admet-661	216	55	at	at	ADP
admet-661	216	56	ph>5	ph>5	PROPN
admet-661	216	57	,	,	PUNCT
admet-661	216	58	the	the	DET
admet-661	216	59	full	full	ADJ
admet-661	216	60	conversion	conversion	NOUN
admet-661	216	61	of	of	ADP
admet-661	216	62	the	the	DET
admet-661	216	63	solid	solid	ADJ
admet-661	216	64	phase	phase	NOUN
admet-661	216	65	to	to	ADP
admet-661	216	66	the	the	DET
admet-661	216	67	free	free	ADJ
admet-661	216	68	base	base	NOUN
admet-661	216	69	form	form	NOUN
admet-661	216	70	was	be	AUX
admet-661	216	71	observed	observe	VERB
admet-661	216	72	.	.	PUNCT
admet-661	217	1	it	it	PRON
admet-661	217	2	is	be	AUX
admet-661	217	3	apparent	apparent	ADJ
admet-661	217	4	that	that	SCONJ
admet-661	217	5	when	when	SCONJ
admet-661	217	6	alkali	alkali	ADJ
admet-661	217	7	is	be	AUX
admet-661	217	8	added	add	VERB
admet-661	217	9	to	to	PART
admet-661	217	10	adjust	adjust	VERB
admet-661	217	11	ph	ph	VERB
admet-661	217	12	,	,	PUNCT
admet-661	217	13	it	it	PRON
admet-661	217	14	neutralizes	neutralize	VERB
admet-661	217	15	the	the	DET
admet-661	217	16	acidic	acidic	ADJ
admet-661	217	17	coformers	coformer	NOUN
admet-661	217	18	for	for	ADP
admet-661	217	19	partial	partial	ADJ
admet-661	217	20	conversion	conversion	NOUN
admet-661	217	21	of	of	ADP
admet-661	217	22	the	the	DET
admet-661	217	23	solid	solid	ADJ
admet-661	217	24	phase	phase	NOUN
admet-661	217	25	to	to	ADP
admet-661	217	26	the	the	DET
admet-661	217	27	free	free	ADJ
admet-661	217	28	base	base	NOUN
admet-661	217	29	,	,	PUNCT
admet-661	217	30	and	and	CCONJ
admet-661	217	31	when	when	SCONJ
admet-661	217	32	sufficient	sufficient	ADJ
admet-661	217	33	alkali	alkali	NOUN
admet-661	217	34	is	be	AUX
admet-661	217	35	added	add	VERB
admet-661	217	36	and	and	CCONJ
admet-661	217	37	the	the	DET
admet-661	217	38	ph	ph	NOUN
admet-661	217	39	rises	rise	NOUN
admet-661	217	40	above	above	ADP
admet-661	217	41	5	5	NUM
admet-661	217	42	,	,	PUNCT
admet-661	217	43	all	all	DET
admet-661	217	44	the	the	DET
admet-661	217	45	excess	excess	ADJ
admet-661	217	46	cocrystals	cocrystal	NOUN
admet-661	217	47	convert	convert	VERB
admet-661	217	48	to	to	ADP
admet-661	217	49	the	the	DET
admet-661	217	50	free	free	ADJ
admet-661	217	51	base	base	NOUN
admet-661	217	52	.	.	PUNCT
admet-661	218	1	it	it	PRON
admet-661	218	2	is	be	AUX
admet-661	218	3	possible	possible	ADJ
admet-661	218	4	that	that	SCONJ
admet-661	218	5	initially	initially	ADV
admet-661	218	6	formed	form	VERB
admet-661	218	7	free	free	ADJ
admet-661	218	8	base	base	NOUN
admet-661	218	9	coated	coat	VERB
admet-661	218	10	the	the	DET
admet-661	218	11	surface	surface	NOUN
admet-661	218	12	of	of	ADP
admet-661	218	13	cocrystal	cocrystal	ADJ
admet-661	218	14	particles	particle	NOUN
admet-661	218	15	and	and	CCONJ
admet-661	218	16	thereby	thereby	ADV
admet-661	218	17	only	only	ADV
admet-661	218	18	the	the	DET
admet-661	218	19	free	free	ADJ
admet-661	218	20	base	base	NOUN
admet-661	218	21	was	be	AUX
admet-661	218	22	in	in	ADP
admet-661	218	23	equilibrium	equilibrium	NOUN
admet-661	218	24	with	with	ADP
admet-661	218	25	the	the	DET
admet-661	218	26	solution	solution	NOUN
admet-661	218	27	.	.	PUNCT
admet-661	219	1	these	these	DET
admet-661	219	2	results	result	NOUN
admet-661	219	3	demonstrate	demonstrate	VERB
admet-661	219	4	that	that	SCONJ
admet-661	219	5	the	the	DET
admet-661	219	6	solubility	solubility	NOUN
admet-661	219	7	of	of	ADP
admet-661	219	8	cocrystals	cocrystal	NOUN
admet-661	219	9	follows	follow	VERB
admet-661	219	10	the	the	DET
admet-661	219	11	general	general	ADJ
admet-661	219	12	ph	ph	ADJ
admet-661	219	13	-	-	PUNCT
admet-661	219	14	solubility	solubility	NOUN
admet-661	219	15	profile	profile	NOUN
admet-661	219	16	of	of	ADP
admet-661	219	17	free	free	ADJ
admet-661	219	18	base	base	NOUN
admet-661	219	19	above	above	ADP
admet-661	219	20	a	a	DET
admet-661	219	21	certain	certain	ADJ
admet-661	219	22	critical	critical	ADJ
admet-661	219	23	ph	ph	NOUN
admet-661	219	24	value	value	NOUN
admet-661	219	25	,	,	PUNCT
admet-661	219	26	where	where	SCONJ
admet-661	219	27	the	the	DET
admet-661	219	28	solubility	solubility	NOUN
admet-661	219	29	decreases	decrease	VERB
admet-661	219	30	with	with	ADP
admet-661	219	31	the	the	DET
admet-661	219	32	increase	increase	NOUN
admet-661	219	33	in	in	ADP
admet-661	219	34	ph	ph	PROPN
admet-661	219	35	.	.	PUNCT
admet-661	220	1	this	this	PRON
admet-661	220	2	is	be	AUX
admet-661	220	3	analogous	analogous	ADJ
admet-661	220	4	to	to	ADP
admet-661	220	5	the	the	DET
admet-661	220	6	decrease	decrease	NOUN
admet-661	220	7	in	in	ADP
admet-661	220	8	solubility	solubility	NOUN
admet-661	220	9	of	of	ADP
admet-661	220	10	pharmaceutical	pharmaceutical	ADJ
admet-661	220	11	salts	salt	NOUN
admet-661	220	12	above	above	ADP
admet-661	220	13	the	the	DET
admet-661	220	14	phmax	phmax	NOUN
admet-661	220	15	,	,	PUNCT
admet-661	220	16	i.e.	i.e.	X
admet-661	220	17	,	,	PUNCT
admet-661	220	18	the	the	DET
admet-661	220	19	ph	ph	NOUN
admet-661	220	20	of	of	ADP
admet-661	220	21	maximum	maximum	ADJ
admet-661	220	22	solubility	solubility	NOUN
admet-661	220	23	,	,	PUNCT
admet-661	220	24	as	as	ADP
admet-661	220	25	a	a	DET
admet-661	220	26	function	function	NOUN
admet-661	220	27	of	of	ADP
admet-661	220	28	ph	ph	NOUN
admet-661	220	29	[	[	X
admet-661	220	30	32	32	NUM
admet-661	220	31	]	]	PUNCT
admet-661	220	32	.	.	PUNCT
admet-661	221	1	vasoya	vasoya	PROPN
admet-661	221	2	et	et	PROPN
admet-661	221	3	al	al	PROPN
admet-661	221	4	.	.	PROPN
admet-661	221	5	admet	admet	PROPN
admet-661	221	6	&	&	CCONJ
admet-661	221	7	dmpk	dmpk	PROPN
admet-661	221	8	7(2	7(2	NUM
admet-661	221	9	)	)	PUNCT
admet-661	221	10	(	(	PUNCT
admet-661	221	11	2019	2019	NUM
admet-661	221	12	)	)	PUNCT
admet-661	221	13	106	106	NUM
admet-661	221	14	-	-	SYM
admet-661	221	15	130	130	NUM
admet-661	221	16	118	118	NUM
admet-661	221	17	solubility	solubility	NOUN
admet-661	221	18	of	of	ADP
admet-661	221	19	ketoconazole	ketoconazole	PROPN
admet-661	221	20	cocrystals	cocrystal	NOUN
admet-661	221	21	at	at	ADP
admet-661	221	22	different	different	ADJ
admet-661	221	23	ph	ph	NOUN
admet-661	221	24	in	in	ADP
admet-661	221	25	buffered	buffer	VERB
admet-661	221	26	solutions	solution	NOUN
admet-661	221	27	in	in	ADP
admet-661	221	28	the	the	DET
admet-661	221	29	above	above	ADJ
admet-661	221	30	section	section	NOUN
admet-661	221	31	,	,	PUNCT
admet-661	221	32	fig	fig	NOUN
admet-661	221	33	.	.	PUNCT
admet-661	222	1	5	5	NUM
admet-661	222	2	shows	show	VERB
admet-661	222	3	a	a	DET
admet-661	222	4	decrease	decrease	NOUN
admet-661	222	5	in	in	ADP
admet-661	222	6	solubility	solubility	NOUN
admet-661	222	7	of	of	ADP
admet-661	222	8	ketoconazole	ketoconazole	PROPN
admet-661	222	9	cocrystals	cocrystal	NOUN
admet-661	222	10	with	with	ADP
admet-661	222	11	the	the	DET
admet-661	222	12	increase	increase	NOUN
admet-661	222	13	in	in	ADP
admet-661	222	14	ph	ph	PROPN
admet-661	222	15	.	.	PUNCT
admet-661	223	1	however	however	ADV
admet-661	223	2	,	,	PUNCT
admet-661	223	3	as	as	SCONJ
admet-661	223	4	mentioned	mention	VERB
admet-661	223	5	earlier	early	ADV
admet-661	223	6	,	,	PUNCT
admet-661	223	7	there	there	PRON
admet-661	223	8	are	be	VERB
admet-661	223	9	reports	report	NOUN
admet-661	223	10	in	in	ADP
admet-661	223	11	the	the	DET
admet-661	223	12	literature	literature	NOUN
admet-661	223	13	where	where	SCONJ
admet-661	223	14	increased	increase	VERB
admet-661	223	15	solubility	solubility	NOUN
admet-661	223	16	of	of	ADP
admet-661	223	17	cocrystals	cocrystal	NOUN
admet-661	223	18	under	under	ADP
admet-661	223	19	high	high	ADJ
admet-661	223	20	ph	ph	NOUN
admet-661	223	21	conditions	condition	NOUN
admet-661	223	22	was	be	AUX
admet-661	223	23	predicted	predict	VERB
admet-661	223	24	based	base	VERB
admet-661	223	25	on	on	ADP
admet-661	223	26	theoretical	theoretical	ADJ
admet-661	223	27	calculations	calculation	NOUN
admet-661	224	1	only	only	ADV
admet-661	224	2	[	[	X
admet-661	224	3	20	20	NUM
admet-661	224	4	]	]	PUNCT
admet-661	224	5	.	.	PUNCT
admet-661	225	1	since	since	SCONJ
admet-661	225	2	,	,	PUNCT
admet-661	225	3	for	for	ADP
admet-661	225	4	the	the	DET
admet-661	225	5	development	development	NOUN
admet-661	225	6	of	of	ADP
admet-661	225	7	drug	drug	NOUN
admet-661	225	8	products	product	NOUN
admet-661	225	9	,	,	PUNCT
admet-661	225	10	it	it	PRON
admet-661	225	11	is	be	AUX
admet-661	225	12	necessary	necessary	ADJ
admet-661	225	13	to	to	PART
admet-661	225	14	experimentally	experimentally	ADV
admet-661	225	15	ascertain	ascertain	VERB
admet-661	225	16	solubility	solubility	NOUN
admet-661	225	17	and	and	CCONJ
admet-661	225	18	dissolution	dissolution	NOUN
admet-661	225	19	rate	rate	NOUN
admet-661	225	20	in	in	ADP
admet-661	225	21	the	the	DET
admet-661	225	22	gastrointestinal	gastrointestinal	ADJ
admet-661	225	23	ph	ph	ADJ
admet-661	225	24	range	range	NOUN
admet-661	225	25	,	,	PUNCT
admet-661	225	26	the	the	DET
admet-661	225	27	solubility	solubility	NOUN
admet-661	225	28	of	of	ADP
admet-661	225	29	ketoconazole	ketoconazole	PROPN
admet-661	225	30	cocrystals	cocrystal	NOUN
admet-661	225	31	was	be	AUX
admet-661	225	32	also	also	ADV
admet-661	225	33	studied	study	VERB
admet-661	225	34	in	in	ADP
admet-661	225	35	buffered	buffer	VERB
admet-661	225	36	solutions	solution	NOUN
admet-661	225	37	and	and	CCONJ
admet-661	225	38	compared	compare	VERB
admet-661	225	39	with	with	ADP
admet-661	225	40	that	that	PRON
admet-661	225	41	of	of	ADP
admet-661	225	42	the	the	DET
admet-661	225	43	free	free	ADJ
admet-661	225	44	base	base	NOUN
admet-661	225	45	.	.	PUNCT
admet-661	226	1	as	as	SCONJ
admet-661	226	2	shown	show	VERB
admet-661	226	3	in	in	ADP
admet-661	226	4	fig	fig	NOUN
admet-661	226	5	.	.	PUNCT
admet-661	227	1	5	5	NUM
admet-661	227	2	,	,	PUNCT
admet-661	227	3	there	there	PRON
admet-661	227	4	are	be	VERB
admet-661	227	5	certain	certain	ADJ
admet-661	227	6	limits	limit	NOUN
admet-661	227	7	how	how	SCONJ
admet-661	227	8	much	much	ADJ
admet-661	227	9	lowering	lowering	NOUN
admet-661	227	10	of	of	ADP
admet-661	227	11	ph	ph	NOUN
admet-661	227	12	may	may	AUX
admet-661	227	13	be	be	AUX
admet-661	227	14	achieved	achieve	VERB
admet-661	227	15	by	by	ADP
admet-661	227	16	adding	add	VERB
admet-661	227	17	acidic	acidic	ADJ
admet-661	227	18	coformer	coformer	NOUN
admet-661	227	19	solutions	solution	NOUN
admet-661	227	20	.	.	PUNCT
admet-661	228	1	for	for	ADP
admet-661	228	2	this	this	DET
admet-661	228	3	reason	reason	NOUN
admet-661	228	4	,	,	PUNCT
admet-661	228	5	the	the	DET
admet-661	228	6	solubility	solubility	NOUN
admet-661	228	7	of	of	ADP
admet-661	228	8	ketoconazole	ketoconazole	PROPN
admet-661	228	9	cocrystals	cocrystal	NOUN
admet-661	228	10	was	be	AUX
admet-661	228	11	also	also	ADV
admet-661	228	12	determined	determine	VERB
admet-661	228	13	in	in	ADP
admet-661	228	14	acidic	acidic	ADJ
admet-661	228	15	buffers	buffer	NOUN
admet-661	228	16	to	to	PART
admet-661	228	17	mimic	mimic	VERB
admet-661	228	18	gastric	gastric	ADJ
admet-661	228	19	ph	ph	ADJ
admet-661	228	20	conditions	condition	NOUN
admet-661	228	21	.	.	PUNCT
admet-661	229	1	the	the	DET
admet-661	229	2	results	result	NOUN
admet-661	229	3	of	of	ADP
admet-661	229	4	these	these	DET
admet-661	229	5	studies	study	NOUN
admet-661	229	6	are	be	AUX
admet-661	229	7	tabulated	tabulate	VERB
admet-661	229	8	in	in	ADP
admet-661	229	9	table	table	NOUN
admet-661	229	10	2	2	NUM
admet-661	229	11	.	.	PUNCT
admet-661	230	1	it	it	PRON
admet-661	230	2	may	may	AUX
admet-661	230	3	be	be	AUX
admet-661	230	4	noted	note	VERB
admet-661	230	5	in	in	ADP
admet-661	230	6	this	this	DET
admet-661	230	7	table	table	NOUN
admet-661	230	8	that	that	SCONJ
admet-661	230	9	there	there	PRON
admet-661	230	10	were	be	VERB
admet-661	230	11	certain	certain	ADJ
admet-661	230	12	shifts	shift	NOUN
admet-661	230	13	in	in	ADP
admet-661	230	14	ph	ph	NOUN
admet-661	230	15	of	of	ADP
admet-661	230	16	buffers	buffer	NOUN
admet-661	230	17	after	after	ADP
admet-661	230	18	equilibration	equilibration	NOUN
admet-661	230	19	with	with	ADP
admet-661	230	20	solids	solid	NOUN
admet-661	230	21	,	,	PUNCT
admet-661	230	22	which	which	PRON
admet-661	230	23	may	may	AUX
admet-661	230	24	be	be	AUX
admet-661	230	25	attributed	attribute	VERB
admet-661	230	26	to	to	ADP
admet-661	230	27	the	the	DET
admet-661	230	28	liberation	liberation	NOUN
admet-661	230	29	of	of	ADP
admet-661	230	30	either	either	CCONJ
admet-661	230	31	fumaric	fumaric	ADJ
admet-661	230	32	acid	acid	PROPN
admet-661	230	33	or	or	CCONJ
admet-661	230	34	succinic	succinic	ADJ
admet-661	230	35	acid	acid	NOUN
admet-661	230	36	from	from	ADP
admet-661	230	37	cocrystals	cocrystal	NOUN
admet-661	230	38	.	.	PUNCT
admet-661	231	1	the	the	DET
admet-661	231	2	solubility	solubility	NOUN
admet-661	231	3	of	of	ADP
admet-661	231	4	free	free	ADJ
admet-661	231	5	base	base	NOUN
admet-661	231	6	and	and	CCONJ
admet-661	231	7	cocrystals	cocrystal	NOUN
admet-661	231	8	somewhat	somewhat	ADV
admet-661	231	9	differed	differ	VERB
admet-661	231	10	due	due	ADP
admet-661	231	11	to	to	ADP
admet-661	231	12	the	the	DET
admet-661	231	13	ph	ph	ADJ
admet-661	231	14	shift	shift	NOUN
admet-661	231	15	.	.	PUNCT
admet-661	232	1	difference	difference	NOUN
admet-661	232	2	in	in	ADP
admet-661	232	3	buffer	buffer	NOUN
admet-661	232	4	compositions	composition	NOUN
admet-661	232	5	and	and	CCONJ
admet-661	232	6	ionic	ionic	ADJ
admet-661	232	7	strength	strength	NOUN
admet-661	232	8	may	may	AUX
admet-661	232	9	also	also	ADV
admet-661	232	10	play	play	VERB
admet-661	232	11	roles	role	NOUN
admet-661	232	12	in	in	ADP
admet-661	232	13	the	the	DET
admet-661	232	14	observed	observe	VERB
admet-661	232	15	difference	difference	NOUN
admet-661	232	16	in	in	ADP
admet-661	232	17	solubility	solubility	NOUN
admet-661	232	18	in	in	ADP
admet-661	232	19	table	table	NOUN
admet-661	232	20	2	2	NUM
admet-661	232	21	.	.	PUNCT
admet-661	233	1	however	however	ADV
admet-661	233	2	,	,	PUNCT
admet-661	233	3	overall	overall	ADJ
admet-661	233	4	,	,	PUNCT
admet-661	233	5	table	table	NOUN
admet-661	233	6	2	2	NUM
admet-661	233	7	shows	show	VERB
admet-661	233	8	the	the	DET
admet-661	233	9	solubility	solubility	NOUN
admet-661	233	10	of	of	ADP
admet-661	233	11	ketoconazole	ketoconazole	PROPN
admet-661	233	12	cocrystals	cocrystal	NOUN
admet-661	233	13	indeed	indeed	ADV
admet-661	233	14	decreases	decrease	VERB
admet-661	233	15	at	at	ADP
admet-661	233	16	relatively	relatively	ADV
admet-661	233	17	higher	high	ADJ
admet-661	233	18	ph	ph	ADJ
admet-661	233	19	conditions	condition	NOUN
admet-661	233	20	and	and	CCONJ
admet-661	233	21	the	the	DET
admet-661	233	22	solubility	solubility	NOUN
admet-661	233	23	of	of	ADP
admet-661	233	24	free	free	ADJ
admet-661	233	25	base	base	NOUN
admet-661	233	26	and	and	CCONJ
admet-661	233	27	cocrystals	cocrystal	NOUN
admet-661	233	28	under	under	ADP
admet-661	233	29	such	such	ADJ
admet-661	233	30	ph	ph	ADJ
admet-661	233	31	conditions	condition	NOUN
admet-661	233	32	are	be	AUX
admet-661	233	33	essentially	essentially	ADV
admet-661	233	34	similar	similar	ADJ
admet-661	233	35	.	.	PUNCT
admet-661	234	1	such	such	ADJ
admet-661	234	2	similarity	similarity	NOUN
admet-661	234	3	in	in	ADP
admet-661	234	4	phsolubility	phsolubility	NOUN
admet-661	234	5	profiles	profile	NOUN
admet-661	234	6	of	of	ADP
admet-661	234	7	ketoconazole	ketoconazole	NOUN
admet-661	234	8	cocrystals	cocrystal	NOUN
admet-661	234	9	and	and	CCONJ
admet-661	234	10	free	free	ADJ
admet-661	234	11	base	base	NOUN
admet-661	234	12	is	be	AUX
admet-661	234	13	analogous	analogous	ADJ
admet-661	234	14	to	to	ADP
admet-661	234	15	the	the	DET
admet-661	234	16	similarity	similarity	NOUN
admet-661	234	17	in	in	ADP
admet-661	234	18	ph	ph	ADJ
admet-661	234	19	-	-	PUNCT
admet-661	234	20	solubility	solubility	NOUN
admet-661	234	21	profiles	profile	NOUN
admet-661	234	22	of	of	ADP
admet-661	234	23	salt	salt	NOUN
admet-661	234	24	and	and	CCONJ
admet-661	234	25	free	free	ADJ
admet-661	234	26	base	base	NOUN
admet-661	234	27	irrespective	irrespective	ADV
admet-661	234	28	of	of	ADP
admet-661	234	29	whether	whether	SCONJ
admet-661	234	30	one	one	NUM
admet-661	234	31	or	or	CCONJ
admet-661	234	32	the	the	DET
admet-661	234	33	other	other	ADJ
admet-661	234	34	is	be	AUX
admet-661	234	35	used	use	VERB
admet-661	234	36	as	as	ADP
admet-661	234	37	starting	start	VERB
admet-661	234	38	material	material	NOUN
admet-661	234	39	to	to	PART
admet-661	234	40	determine	determine	VERB
admet-661	234	41	solubility	solubility	NOUN
admet-661	234	42	[	[	X
admet-661	234	43	30	30	NUM
admet-661	234	44	,	,	PUNCT
admet-661	234	45	33	33	NUM
admet-661	234	46	]	]	PUNCT
admet-661	234	47	.	.	PUNCT
admet-661	235	1	figure	figure	NOUN
admet-661	235	2	5	5	NUM
admet-661	235	3	.	.	PUNCT
admet-661	235	4	ph	ph	ADJ
admet-661	235	5	versus	versus	ADP
admet-661	235	6	solubility	solubility	NOUN
admet-661	235	7	profiles	profile	NOUN
admet-661	235	8	of	of	ADP
admet-661	235	9	ketoconazole	ketoconazole	NOUN
admet-661	235	10	-	-	PUNCT
admet-661	235	11	fumaric	fumaric	NOUN
admet-661	235	12	acid	acid	NOUN
admet-661	235	13	and	and	CCONJ
admet-661	235	14	ketoconazole	ketoconazole	NOUN
admet-661	235	15	-	-	PUNCT
admet-661	235	16	succinic	succinic	ADJ
admet-661	235	17	acid	acid	NOUN
admet-661	235	18	cocrystals	cocrystal	NOUN
admet-661	235	19	determined	determine	VERB
admet-661	235	20	by	by	ADP
admet-661	235	21	using	use	VERB
admet-661	235	22	respective	respective	ADJ
admet-661	235	23	acidic	acidic	ADJ
admet-661	235	24	coformers	coformer	NOUN
admet-661	235	25	at	at	ADP
admet-661	235	26	ph	ph	NOUN
admet-661	235	27	lower	low	ADJ
admet-661	235	28	than	than	ADP
admet-661	235	29	the	the	DET
admet-661	235	30	ph	ph	NOUN
admet-661	235	31	of	of	ADP
admet-661	235	32	saturated	saturate	VERB
admet-661	235	33	solutions	solution	NOUN
admet-661	235	34	of	of	ADP
admet-661	235	35	cocrystals	cocrystal	NOUN
admet-661	235	36	in	in	ADP
admet-661	235	37	water	water	NOUN
admet-661	235	38	and	and	CCONJ
admet-661	235	39	by	by	ADP
admet-661	235	40	using	use	VERB
admet-661	235	41	naoh	naoh	NOUN
admet-661	235	42	to	to	PART
admet-661	235	43	obtain	obtain	VERB
admet-661	235	44	higher	high	ADJ
admet-661	235	45	ph	ph	NOUN
admet-661	235	46	.	.	PUNCT
admet-661	236	1	the	the	DET
admet-661	236	2	solubility	solubility	NOUN
admet-661	236	3	of	of	ADP
admet-661	236	4	the	the	DET
admet-661	236	5	ketoconazole	ketoconazole	NOUN
admet-661	236	6	free	free	ADJ
admet-661	236	7	base	base	NOUN
admet-661	236	8	determined	determine	VERB
admet-661	236	9	by	by	ADP
admet-661	236	10	adjusting	adjust	VERB
admet-661	236	11	ph	ph	PROPN
admet-661	236	12	with	with	ADP
admet-661	236	13	hcl	hcl	PROPN
admet-661	236	14	is	be	AUX
admet-661	236	15	also	also	ADV
admet-661	236	16	plotted	plot	VERB
admet-661	236	17	for	for	ADP
admet-661	236	18	reference	reference	NOUN
admet-661	236	19	.	.	PUNCT
admet-661	237	1	admet	admet	PROPN
admet-661	237	2	&	&	CCONJ
admet-661	237	3	dmpk	dmpk	PROPN
admet-661	237	4	7(2	7(2	NUM
admet-661	237	5	)	)	PUNCT
admet-661	237	6	(	(	PUNCT
admet-661	237	7	2019	2019	NUM
admet-661	237	8	)	)	PUNCT
admet-661	237	9	106	106	NUM
admet-661	237	10	-	-	SYM
admet-661	237	11	130	130	NUM
admet-661	237	12	solubility	solubility	NOUN
admet-661	237	13	and	and	CCONJ
admet-661	237	14	dissolution	dissolution	NOUN
admet-661	237	15	of	of	ADP
admet-661	237	16	cocrystals	cocrystal	NOUN
admet-661	237	17	doi	doi	NOUN
admet-661	237	18	:	:	PUNCT
admet-661	237	19	10.5599	10.5599	NUM
admet-661	237	20	/	/	SYM
admet-661	237	21	admet.661	admet.661	PROPN
admet-661	237	22	119	119	NUM
admet-661	237	23	table	table	NOUN
admet-661	237	24	2	2	NUM
admet-661	237	25	.	.	PUNCT
admet-661	237	26	solubility	solubility	NOUN
admet-661	237	27	of	of	ADP
admet-661	237	28	ketoconazole	ketoconazole	PROPN
admet-661	237	29	(	(	PUNCT
admet-661	237	30	ktz	ktz	NOUN
admet-661	237	31	)	)	PUNCT
admet-661	237	32	base	base	NOUN
admet-661	237	33	,	,	PUNCT
admet-661	237	34	ketoconazole	ketoconazole	NOUN
admet-661	237	35	-	-	PUNCT
admet-661	237	36	fumaric	fumaric	ADJ
admet-661	237	37	acid	acid	PROPN
admet-661	237	38	cocrystal	cocrystal	PROPN
admet-661	237	39	and	and	CCONJ
admet-661	237	40	ketoconazole	ketoconazole	NOUN
admet-661	237	41	-	-	PUNCT
admet-661	237	42	succinic	succinic	ADJ
admet-661	237	43	acid	acid	NOUN
admet-661	237	44	cocrystal	cocrystal	NOUN
admet-661	237	45	in	in	ADP
admet-661	237	46	different	different	ADJ
admet-661	237	47	buffer	buffer	NOUN
admet-661	237	48	solutions	solution	NOUN
admet-661	237	49	along	along	ADP
admet-661	237	50	with	with	ADP
admet-661	237	51	initial	initial	ADJ
admet-661	237	52	ph	ph	NOUN
admet-661	237	53	of	of	ADP
admet-661	237	54	buffers	buffer	NOUN
admet-661	237	55	and	and	CCONJ
admet-661	237	56	ph	ph	NOUN
admet-661	237	57	after	after	ADP
admet-661	237	58	equilibration	equilibration	NOUN
admet-661	237	59	with	with	ADP
admet-661	237	60	solids	solid	NOUN
admet-661	237	61	.	.	PUNCT
admet-661	238	1	solubility	solubility	NOUN
admet-661	238	2	represent	represent	VERB
admet-661	238	3	average	average	NOUN
admet-661	238	4	of	of	ADP
admet-661	238	5	three	three	NUM
admet-661	238	6	determinations	determination	NOUN
admet-661	238	7	(	(	PUNCT
admet-661	238	8	±	±	NOUN
admet-661	238	9	standard	standard	ADJ
admet-661	238	10	deviation	deviation	NOUN
admet-661	238	11	)	)	PUNCT
admet-661	238	12	.	.	PUNCT
admet-661	239	1	initial	initial	ADJ
admet-661	239	2	ph	ph	NOUN
admet-661	239	3	and	and	CCONJ
admet-661	239	4	buffers	buffer	NOUN
admet-661	239	5	used	use	VERB
admet-661	239	6	ketoconazole	ketoconazole	NOUN
admet-661	239	7	(	(	PUNCT
admet-661	239	8	ktz	ktz	PROPN
admet-661	239	9	)	)	PUNCT
admet-661	239	10	ktz	ktz	PROPN
admet-661	239	11	-	-	PUNCT
admet-661	239	12	fumaric	fumaric	ADJ
admet-661	239	13	acid	acid	PROPN
admet-661	239	14	cocrystal	cocrystal	PROPN
admet-661	239	15	ktz	ktz	PROPN
admet-661	239	16	-	-	PUNCT
admet-661	239	17	succinic	succinic	ADJ
admet-661	239	18	acid	acid	NOUN
admet-661	239	19	cocrystal	cocrystal	NOUN
admet-661	239	20	ph	ph	NOUN
admet-661	239	21	after	after	ADP
admet-661	239	22	equilibrat	equilibrat	NOUN
admet-661	239	23	ion	ion	NOUN
admet-661	239	24	solubility	solubility	NOUN
admet-661	239	25	(	(	PUNCT
admet-661	239	26	mg	mg	PROPN
admet-661	239	27	/	/	SYM
admet-661	239	28	ml	ml	NOUN
admet-661	239	29	)	)	PUNCT
admet-661	239	30	ph	ph	NOUN
admet-661	239	31	after	after	ADP
admet-661	239	32	equilibration	equilibration	NOUN
admet-661	239	33	solubility	solubility	NOUN
admet-661	239	34	(	(	PUNCT
admet-661	239	35	mg	mg	PROPN
admet-661	239	36	/	/	SYM
admet-661	239	37	ml	ml	NOUN
admet-661	239	38	)	)	PUNCT
admet-661	239	39	ph	ph	NOUN
admet-661	239	40	after	after	ADP
admet-661	239	41	equilibration	equilibration	NOUN
admet-661	239	42	solubility	solubility	NOUN
admet-661	239	43	(	(	PUNCT
admet-661	239	44	mg	mg	PROPN
admet-661	239	45	/	/	SYM
admet-661	239	46	ml	ml	NOUN
admet-661	239	47	)	)	PUNCT
admet-661	239	48	ph	ph	NOUN
admet-661	239	49	1.1	1.1	NUM
admet-661	239	50	(	(	PUNCT
admet-661	239	51	0.1	0.1	NUM
admet-661	239	52	m	m	NOUN
admet-661	239	53	hcl	hcl	NOUN
admet-661	239	54	)	)	PUNCT
admet-661	239	55	2.9	2.9	NUM
admet-661	239	56	*	*	SYM
admet-661	239	57	27	27	NUM
admet-661	239	58	*	*	SYM
admet-661	239	59	2.03±	2.03±	NUM
admet-661	239	60	0.01	0.01	NUM
admet-661	239	61	21.54±	21.54±	NUM
admet-661	239	62	0.55	0.55	NUM
admet-661	239	63	2.52±	2.52±	NUM
admet-661	239	64	0.05	0.05	NUM
admet-661	239	65	23.99±	23.99±	NUM
admet-661	239	66	0.30	0.30	NUM
admet-661	239	67	ph	ph	NOUN
admet-661	239	68	2.1	2.1	NUM
admet-661	239	69	hcl	hcl	PROPN
admet-661	239	70	/	/	SYM
admet-661	239	71	kcl	kcl	PROPN
admet-661	239	72	buffer	buffer	VERB
admet-661	239	73	3.6	3.6	NUM
admet-661	239	74	*	*	SYM
admet-661	239	75	3.4	3.4	NUM
admet-661	239	76	*	*	SYM
admet-661	239	77	2.89	2.89	NUM
admet-661	239	78	±	±	NUM
admet-661	239	79	0.02	0.02	NUM
admet-661	239	80	3.39±	3.39±	NUM
admet-661	239	81	0.02	0.02	NUM
admet-661	239	82	3.38	3.38	NUM
admet-661	239	83	±	±	NUM
admet-661	239	84	0.00	0.00	NUM
admet-661	239	85	3.69±	3.69±	NUM
admet-661	240	1	0.07	0.07	NUM
admet-661	240	2	ph	ph	PROPN
admet-661	240	3	5.0	5.0	NUM
admet-661	240	4	acetate	acetate	NOUN
admet-661	240	5	buffer	buffer	NOUN
admet-661	240	6	4.95	4.95	NUM
admet-661	240	7	0.13	0.13	NUM
admet-661	240	8	4.31	4.31	NUM
admet-661	240	9	±	±	NUM
admet-661	240	10	0.02	0.02	NUM
admet-661	240	11	0.60±	0.60±	NUM
admet-661	240	12	0.02	0.02	NUM
admet-661	240	13	4.60±	4.60±	NOUN
admet-661	240	14	0.02	0.02	NUM
admet-661	240	15	0.38±	0.38±	NUM
admet-661	240	16	0.03	0.03	NUM
admet-661	240	17	ph	ph	NOUN
admet-661	240	18	7.9	7.9	NUM
admet-661	240	19	phosphate	phosphate	NOUN
admet-661	240	20	buffer	buffer	NOUN
admet-661	240	21	7.82±0.01	7.82±0.01	NUM
admet-661	240	22	0.001±0.000	0.001±0.000	NUM
admet-661	240	23	7.17	7.17	NUM
admet-661	240	24	±	±	NUM
admet-661	240	25	0.01	0.01	NUM
admet-661	240	26	0.003±	0.003±	NUM
admet-661	240	27	0.002	0.002	NUM
admet-661	240	28	7.14	7.14	NUM
admet-661	240	29	±	±	NUM
admet-661	240	30	0.01	0.01	NUM
admet-661	240	31	0.006±	0.006±	NUM
admet-661	240	32	0.001	0.001	NUM
admet-661	240	33	*	*	NUM
admet-661	240	34	approximate	approximate	ADJ
admet-661	240	35	ph	ph	NOUN
admet-661	240	36	and	and	CCONJ
admet-661	240	37	solubility	solubility	NOUN
admet-661	240	38	.	.	PUNCT
admet-661	241	1	as	as	SCONJ
admet-661	241	2	more	more	ADV
admet-661	241	3	solid	solid	ADJ
admet-661	241	4	materials	material	NOUN
admet-661	241	5	are	be	AUX
admet-661	241	6	added	add	VERB
admet-661	241	7	,	,	PUNCT
admet-661	241	8	ph	ph	ADJ
admet-661	241	9	shifts	shift	NOUN
admet-661	241	10	and	and	CCONJ
admet-661	241	11	solubility	solubility	NOUN
admet-661	241	12	changes	change	NOUN
admet-661	241	13	.	.	PUNCT
admet-661	242	1	ph	ph	ADJ
admet-661	242	2	versus	versus	ADP
admet-661	242	3	solubility	solubility	NOUN
admet-661	242	4	profiles	profile	NOUN
admet-661	242	5	of	of	ADP
admet-661	242	6	ketoconazole	ketoconazole	NOUN
admet-661	242	7	determined	determine	VERB
admet-661	242	8	by	by	ADP
admet-661	242	9	adding	add	VERB
admet-661	242	10	fumaric	fumaric	ADJ
admet-661	242	11	acid	acid	PROPN
admet-661	242	12	and	and	CCONJ
admet-661	242	13	succinic	succinic	ADJ
admet-661	242	14	acid	acid	NOUN
admet-661	242	15	it	it	PRON
admet-661	242	16	has	have	AUX
admet-661	242	17	been	be	AUX
admet-661	242	18	shown	show	VERB
admet-661	242	19	earlier	early	ADV
admet-661	242	20	in	in	ADP
admet-661	242	21	fig	fig	NOUN
admet-661	242	22	.	.	PUNCT
admet-661	243	1	5	5	NUM
admet-661	243	2	that	that	SCONJ
admet-661	243	3	the	the	DET
admet-661	243	4	solubility	solubility	NOUN
admet-661	243	5	of	of	ADP
admet-661	243	6	cocrystals	cocrystal	NOUN
admet-661	243	7	was	be	AUX
admet-661	243	8	influenced	influence	VERB
admet-661	243	9	by	by	ADP
admet-661	243	10	ph	ph	NOUN
admet-661	243	11	;	;	PUNCT
admet-661	243	12	when	when	SCONJ
admet-661	243	13	ph	ph	PROPN
admet-661	243	14	was	be	AUX
admet-661	243	15	raised	raise	VERB
admet-661	243	16	above	above	ADP
admet-661	243	17	~ph	~ph	PROPN
admet-661	243	18	4.1	4.1	NUM
admet-661	243	19	,	,	PUNCT
admet-661	243	20	the	the	DET
admet-661	243	21	cocrystals	cocrystal	NOUN
admet-661	243	22	converted	convert	VERB
admet-661	243	23	gradually	gradually	ADV
admet-661	243	24	to	to	ADP
admet-661	243	25	free	free	ADJ
admet-661	243	26	base	base	NOUN
admet-661	243	27	and	and	CCONJ
admet-661	243	28	the	the	DET
admet-661	243	29	solubility	solubility	NOUN
admet-661	243	30	decreased	decrease	VERB
admet-661	243	31	.	.	PUNCT
admet-661	244	1	on	on	ADP
admet-661	244	2	the	the	DET
admet-661	244	3	other	other	ADJ
admet-661	244	4	hand	hand	NOUN
admet-661	244	5	,	,	PUNCT
admet-661	244	6	when	when	SCONJ
admet-661	244	7	ph	ph	NOUN
admet-661	244	8	of	of	ADP
admet-661	244	9	the	the	DET
admet-661	244	10	solutions	solution	NOUN
admet-661	244	11	was	be	AUX
admet-661	244	12	reduced	reduce	VERB
admet-661	244	13	by	by	ADP
admet-661	244	14	adding	add	VERB
admet-661	244	15	respective	respective	ADJ
admet-661	244	16	acids	acid	NOUN
admet-661	244	17	(	(	PUNCT
admet-661	244	18	coformers	coformer	NOUN
admet-661	244	19	)	)	PUNCT
admet-661	244	20	,	,	PUNCT
admet-661	244	21	the	the	DET
admet-661	244	22	solid	solid	ADJ
admet-661	244	23	phase	phase	NOUN
admet-661	244	24	in	in	ADP
admet-661	244	25	equilibria	equilibrium	NOUN
admet-661	244	26	with	with	ADP
admet-661	244	27	solutions	solution	NOUN
admet-661	244	28	remained	remain	VERB
admet-661	244	29	unchanged	unchanged	ADJ
admet-661	244	30	and	and	CCONJ
admet-661	244	31	the	the	DET
admet-661	244	32	solubility	solubility	NOUN
admet-661	244	33	remained	remain	VERB
admet-661	244	34	high	high	ADJ
admet-661	244	35	.	.	PUNCT
admet-661	245	1	it	it	PRON
admet-661	245	2	was	be	AUX
admet-661	245	3	,	,	PUNCT
admet-661	245	4	therefore	therefore	ADV
admet-661	245	5	,	,	PUNCT
admet-661	245	6	of	of	ADP
admet-661	245	7	interest	interest	NOUN
admet-661	245	8	to	to	PART
admet-661	245	9	determine	determine	VERB
admet-661	245	10	whether	whether	SCONJ
admet-661	245	11	a	a	DET
admet-661	245	12	similar	similar	ADJ
admet-661	245	13	ph	ph	NOUN
admet-661	245	14	versus	versus	ADP
admet-661	245	15	solubility	solubility	NOUN
admet-661	245	16	relationship	relationship	NOUN
admet-661	245	17	would	would	AUX
admet-661	245	18	exist	exist	VERB
admet-661	245	19	when	when	SCONJ
admet-661	245	20	ketoconazole	ketoconazole	PROPN
admet-661	245	21	free	free	ADJ
admet-661	245	22	base	base	NOUN
admet-661	245	23	was	be	AUX
admet-661	245	24	used	use	VERB
admet-661	245	25	as	as	ADP
admet-661	245	26	the	the	DET
admet-661	245	27	starting	starting	NOUN
admet-661	245	28	material	material	NOUN
admet-661	245	29	and	and	CCONJ
admet-661	245	30	the	the	DET
admet-661	245	31	ph	ph	NOUN
admet-661	245	32	was	be	AUX
admet-661	245	33	adjusted	adjust	VERB
admet-661	245	34	using	use	VERB
admet-661	245	35	fumaric	fumaric	ADJ
admet-661	245	36	acid	acid	PROPN
admet-661	245	37	and	and	CCONJ
admet-661	245	38	succinic	succinic	ADJ
admet-661	245	39	acid	acid	NOUN
admet-661	245	40	.	.	PUNCT
admet-661	246	1	in	in	ADP
admet-661	246	2	particular	particular	ADJ
admet-661	246	3	,	,	PUNCT
admet-661	246	4	any	any	DET
admet-661	246	5	possible	possible	ADJ
admet-661	246	6	conversion	conversion	NOUN
admet-661	246	7	of	of	ADP
admet-661	246	8	ketoconazole	ketoconazole	NOUN
admet-661	246	9	to	to	ADP
admet-661	246	10	cocrystals	cocrystal	NOUN
admet-661	246	11	by	by	ADP
admet-661	246	12	the	the	DET
admet-661	246	13	reduction	reduction	NOUN
admet-661	246	14	of	of	ADP
admet-661	246	15	ph	ph	NOUN
admet-661	246	16	during	during	ADP
admet-661	246	17	the	the	DET
admet-661	246	18	determination	determination	NOUN
admet-661	246	19	of	of	ADP
admet-661	246	20	ph	ph	ADJ
admet-661	246	21	-	-	PUNCT
admet-661	246	22	solubility	solubility	NOUN
admet-661	246	23	profile	profile	NOUN
admet-661	246	24	was	be	AUX
admet-661	246	25	studied	study	VERB
admet-661	246	26	.	.	PUNCT
admet-661	247	1	figs	fig	NOUN
admet-661	247	2	.	.	PUNCT
admet-661	248	1	6	6	NUM
admet-661	248	2	and	and	CCONJ
admet-661	248	3	7	7	NUM
admet-661	248	4	give	give	VERB
admet-661	248	5	ph	ph	ADJ
admet-661	248	6	-	-	PUNCT
admet-661	248	7	solubility	solubility	NOUN
admet-661	248	8	profiles	profile	NOUN
admet-661	248	9	of	of	ADP
admet-661	248	10	ketoconazole	ketoconazole	NOUN
admet-661	248	11	with	with	ADP
admet-661	248	12	respect	respect	NOUN
admet-661	248	13	to	to	ADP
admet-661	248	14	fumaric	fumaric	ADJ
admet-661	248	15	acid	acid	PROPN
admet-661	248	16	and	and	CCONJ
admet-661	248	17	succinic	succinic	ADJ
admet-661	248	18	acid	acid	NOUN
admet-661	248	19	.	.	PUNCT
admet-661	249	1	in	in	ADP
admet-661	249	2	these	these	DET
admet-661	249	3	studies	study	NOUN
admet-661	249	4	,	,	PUNCT
admet-661	249	5	the	the	DET
admet-661	249	6	solutions	solution	NOUN
admet-661	249	7	were	be	AUX
admet-661	249	8	equilibrated	equilibrate	VERB
admet-661	249	9	for	for	ADP
admet-661	249	10	96	96	NUM
admet-661	249	11	h.	h.	NOUN
admet-661	249	12	both	both	DET
admet-661	249	13	figs	fig	NOUN
admet-661	249	14	.	.	PUNCT
admet-661	250	1	6	6	NUM
admet-661	250	2	and	and	CCONJ
admet-661	250	3	7	7	NUM
admet-661	250	4	were	be	AUX
admet-661	250	5	generated	generate	VERB
admet-661	250	6	by	by	ADP
admet-661	250	7	dissolving	dissolve	VERB
admet-661	250	8	different	different	ADJ
admet-661	250	9	amounts	amount	NOUN
admet-661	250	10	of	of	ADP
admet-661	250	11	1:1	1:1	NUM
admet-661	250	12	molar	molar	ADJ
admet-661	250	13	mixtures	mixture	NOUN
admet-661	250	14	of	of	ADP
admet-661	250	15	ketoconazole	ketoconazole	NOUN
admet-661	250	16	with	with	ADP
admet-661	250	17	,	,	PUNCT
admet-661	250	18	respectively	respectively	ADV
admet-661	250	19	,	,	PUNCT
admet-661	250	20	fumaric	fumaric	ADJ
admet-661	250	21	acid	acid	PROPN
admet-661	250	22	and	and	CCONJ
admet-661	250	23	succinic	succinic	ADJ
admet-661	250	24	acid	acid	NOUN
admet-661	250	25	;	;	PUNCT
admet-661	250	26	the	the	DET
admet-661	250	27	ph	ph	ADJ
admet-661	250	28	shift	shift	NOUN
admet-661	250	29	occurred	occur	VERB
admet-661	250	30	due	due	ADP
admet-661	250	31	to	to	ADP
admet-661	250	32	the	the	DET
admet-661	250	33	difference	difference	NOUN
admet-661	250	34	in	in	ADP
admet-661	250	35	amounts	amount	NOUN
admet-661	250	36	of	of	ADP
admet-661	250	37	acids	acid	NOUN
admet-661	250	38	present	present	ADJ
admet-661	250	39	in	in	ADP
admet-661	250	40	added	add	VERB
admet-661	250	41	solids	solid	NOUN
admet-661	250	42	.	.	PUNCT
admet-661	251	1	separately	separately	ADV
admet-661	251	2	,	,	PUNCT
admet-661	251	3	solubility	solubility	NOUN
admet-661	251	4	studies	study	NOUN
admet-661	251	5	were	be	AUX
admet-661	251	6	also	also	ADV
admet-661	251	7	conducted	conduct	VERB
admet-661	251	8	using	use	VERB
admet-661	251	9	pre	pre	ADJ
admet-661	251	10	-	-	ADJ
admet-661	251	11	dissolved	dissolved	ADJ
admet-661	251	12	solutions	solution	NOUN
admet-661	251	13	of	of	ADP
admet-661	251	14	fumaric	fumaric	ADJ
admet-661	251	15	acid	acid	PROPN
admet-661	251	16	and	and	CCONJ
admet-661	251	17	succinic	succinic	ADJ
admet-661	251	18	acid	acid	NOUN
admet-661	251	19	and	and	CCONJ
admet-661	251	20	adding	add	VERB
admet-661	251	21	excess	excess	ADJ
admet-661	251	22	ketoconazole	ketoconazole	NOUN
admet-661	251	23	base	base	NOUN
admet-661	251	24	.	.	PUNCT
admet-661	252	1	the	the	DET
admet-661	252	2	results	result	NOUN
admet-661	252	3	were	be	AUX
admet-661	252	4	the	the	DET
admet-661	252	5	same	same	ADJ
admet-661	252	6	whether	whether	SCONJ
admet-661	252	7	physical	physical	ADJ
admet-661	252	8	mixtures	mixture	NOUN
admet-661	252	9	were	be	AUX
admet-661	252	10	used	use	VERB
admet-661	252	11	or	or	CCONJ
admet-661	252	12	the	the	DET
admet-661	252	13	free	free	ADJ
admet-661	252	14	base	base	NOUN
admet-661	252	15	was	be	AUX
admet-661	252	16	added	add	VERB
admet-661	252	17	to	to	ADP
admet-661	252	18	acid	acid	NOUN
admet-661	252	19	solutions	solution	NOUN
admet-661	252	20	,	,	PUNCT
admet-661	252	21	which	which	PRON
admet-661	252	22	indicate	indicate	VERB
admet-661	252	23	that	that	SCONJ
admet-661	252	24	acids	acid	NOUN
admet-661	252	25	from	from	ADP
admet-661	252	26	physical	physical	ADJ
admet-661	252	27	mixtures	mixture	NOUN
admet-661	252	28	first	first	ADV
admet-661	252	29	dissolved	dissolve	VERB
admet-661	252	30	in	in	ADP
admet-661	252	31	water	water	NOUN
admet-661	252	32	and	and	CCONJ
admet-661	252	33	then	then	ADV
admet-661	252	34	the	the	DET
admet-661	252	35	free	free	ADJ
admet-661	252	36	base	base	NOUN
admet-661	252	37	equilibrated	equilibrate	VERB
admet-661	252	38	with	with	ADP
admet-661	252	39	the	the	DET
admet-661	252	40	solution	solution	NOUN
admet-661	252	41	.	.	PUNCT
admet-661	253	1	therefore	therefore	ADV
admet-661	253	2	,	,	PUNCT
admet-661	253	3	we	we	PRON
admet-661	253	4	have	have	AUX
admet-661	253	5	plotted	plot	VERB
admet-661	253	6	only	only	ADJ
admet-661	253	7	data	datum	NOUN
admet-661	253	8	from	from	ADP
admet-661	253	9	physical	physical	ADJ
admet-661	253	10	mixtures	mixture	NOUN
admet-661	253	11	in	in	ADP
admet-661	253	12	figs	fig	NOUN
admet-661	253	13	.	.	PUNCT
admet-661	254	1	6	6	NUM
admet-661	254	2	and	and	CCONJ
admet-661	254	3	7	7	NUM
admet-661	254	4	.	.	X
admet-661	254	5	in	in	ADP
admet-661	254	6	both	both	PRON
admet-661	254	7	of	of	ADP
admet-661	254	8	these	these	DET
admet-661	254	9	figures	figure	NOUN
admet-661	254	10	,	,	PUNCT
admet-661	254	11	the	the	DET
admet-661	254	12	solubility	solubility	NOUN
admet-661	254	13	of	of	ADP
admet-661	254	14	ketoconazole	ketoconazole	NOUN
admet-661	254	15	increased	increase	VERB
admet-661	254	16	gradually	gradually	ADV
admet-661	254	17	with	with	ADP
admet-661	254	18	the	the	DET
admet-661	254	19	decrease	decrease	NOUN
admet-661	254	20	in	in	ADP
admet-661	254	21	ph	ph	NOUN
admet-661	254	22	,	,	PUNCT
admet-661	254	23	and	and	CCONJ
admet-661	254	24	,	,	PUNCT
admet-661	254	25	after	after	ADP
admet-661	254	26	reaching	reach	VERB
admet-661	254	27	peak	peak	NOUN
admet-661	254	28	solubilities	solubility	NOUN
admet-661	254	29	in	in	ADP
admet-661	254	30	the	the	DET
admet-661	254	31	ph	ph	ADJ
admet-661	254	32	range	range	NOUN
admet-661	254	33	of	of	ADP
admet-661	254	34	3.5	3.5	NUM
admet-661	254	35	to	to	ADP
admet-661	254	36	4.0	4.0	NUM
admet-661	254	37	,	,	PUNCT
admet-661	254	38	the	the	DET
admet-661	254	39	solubility	solubility	NOUN
admet-661	254	40	decreased	decrease	VERB
admet-661	254	41	with	with	ADP
admet-661	254	42	further	further	ADJ
admet-661	254	43	addition	addition	NOUN
admet-661	254	44	of	of	ADP
admet-661	254	45	ketoconazole	ketoconazole	NOUN
admet-661	254	46	-	-	PUNCT
admet-661	254	47	coformer	coformer	NOUN
admet-661	254	48	mixture	mixture	NOUN
admet-661	254	49	or	or	CCONJ
admet-661	254	50	the	the	DET
admet-661	254	51	coformer	coformer	NOUN
admet-661	254	52	alone	alone	ADV
admet-661	254	53	.	.	PUNCT
admet-661	255	1	thus	thus	ADV
admet-661	255	2	,	,	PUNCT
admet-661	255	3	it	it	PRON
admet-661	255	4	is	be	AUX
admet-661	255	5	apparent	apparent	ADJ
admet-661	255	6	that	that	SCONJ
admet-661	255	7	,	,	PUNCT
admet-661	255	8	similar	similar	ADJ
admet-661	255	9	to	to	ADP
admet-661	255	10	phmax	phmax	PROPN
admet-661	255	11	(	(	PUNCT
admet-661	255	12	the	the	DET
admet-661	255	13	ph	ph	NOUN
admet-661	255	14	of	of	ADP
admet-661	255	15	maximum	maximum	ADJ
admet-661	255	16	solubility	solubility	NOUN
admet-661	255	17	)	)	PUNCT
admet-661	255	18	generally	generally	ADV
admet-661	255	19	observed	observe	VERB
admet-661	255	20	in	in	ADP
admet-661	255	21	the	the	DET
admet-661	255	22	ph	ph	VERB
admet-661	255	23	-	-	PUNCT
admet-661	255	24	solubility	solubility	NOUN
admet-661	255	25	profile	profile	NOUN
admet-661	255	26	of	of	ADP
admet-661	255	27	a	a	DET
admet-661	255	28	free	free	ADJ
admet-661	255	29	base	base	NOUN
admet-661	255	30	and	and	CCONJ
admet-661	255	31	its	its	PRON
admet-661	255	32	salt	salt	NOUN
admet-661	255	33	form	form	NOUN
admet-661	255	34	,	,	PUNCT
admet-661	255	35	the	the	DET
admet-661	255	36	phmax	phmax	NOUN
admet-661	255	37	also	also	ADV
admet-661	255	38	exists	exist	VERB
admet-661	255	39	for	for	ADP
admet-661	255	40	the	the	DET
admet-661	255	41	cocrystal	cocrystal	ADJ
admet-661	255	42	formation	formation	NOUN
admet-661	255	43	in	in	ADP
admet-661	255	44	aqueous	aqueous	ADJ
admet-661	255	45	media	medium	NOUN
admet-661	255	46	.	.	PUNCT
admet-661	256	1	it	it	PRON
admet-661	256	2	was	be	AUX
admet-661	256	3	confirmed	confirm	VERB
admet-661	256	4	by	by	ADP
admet-661	256	5	dsc	dsc	NOUN
admet-661	256	6	analysis	analysis	NOUN
admet-661	256	7	and	and	CCONJ
admet-661	256	8	in	in	ADP
admet-661	256	9	situ	situ	ADJ
admet-661	256	10	raman	raman	NOUN
admet-661	256	11	analysis	analysis	NOUN
admet-661	256	12	that	that	SCONJ
admet-661	256	13	,	,	PUNCT
admet-661	256	14	above	above	ADP
admet-661	256	15	such	such	ADJ
admet-661	256	16	phmax	phmax	NOUN
admet-661	256	17	,	,	PUNCT
admet-661	256	18	solutions	solution	NOUN
admet-661	256	19	in	in	ADP
admet-661	256	20	both	both	DET
admet-661	256	21	figs	fig	NOUN
admet-661	256	22	.	.	PUNCT
admet-661	257	1	6	6	NUM
admet-661	257	2	and	and	CCONJ
admet-661	257	3	7	7	NUM
admet-661	257	4	were	be	AUX
admet-661	257	5	in	in	ADP
admet-661	257	6	equilibria	equilibrium	NOUN
admet-661	257	7	with	with	ADP
admet-661	257	8	the	the	DET
admet-661	257	9	solid	solid	ADJ
admet-661	257	10	free	free	ADJ
admet-661	257	11	base	base	NOUN
admet-661	257	12	.	.	PUNCT
admet-661	258	1	below	below	ADP
admet-661	258	2	phmax	phmax	NOUN
admet-661	258	3	,	,	PUNCT
admet-661	258	4	solid	solid	ADJ
admet-661	258	5	phases	phase	NOUN
admet-661	258	6	in	in	ADP
admet-661	258	7	equilibria	equilibrium	NOUN
admet-661	258	8	with	with	ADP
admet-661	258	9	solutions	solution	NOUN
admet-661	258	10	were	be	AUX
admet-661	258	11	mixtures	mixture	NOUN
admet-661	258	12	of	of	ADP
admet-661	258	13	cocrystals	cocrystal	NOUN
admet-661	258	14	and	and	CCONJ
admet-661	258	15	free	free	ADJ
admet-661	258	16	base	base	NOUN
admet-661	258	17	.	.	PUNCT
admet-661	259	1	this	this	PRON
admet-661	259	2	is	be	AUX
admet-661	259	3	because	because	SCONJ
admet-661	259	4	when	when	SCONJ
admet-661	259	5	the	the	DET
admet-661	259	6	maximum	maximum	ADJ
admet-661	259	7	solubility	solubility	NOUN
admet-661	259	8	was	be	AUX
admet-661	259	9	reached	reach	VERB
admet-661	259	10	at	at	ADP
admet-661	259	11	phmax	phmax	PROPN
admet-661	259	12	due	due	ADP
admet-661	259	13	the	the	DET
admet-661	259	14	lowering	lowering	NOUN
admet-661	259	15	of	of	ADP
admet-661	259	16	ph	ph	NOUN
admet-661	259	17	,	,	PUNCT
admet-661	259	18	the	the	DET
admet-661	259	19	equilibrium	equilibrium	NOUN
admet-661	259	20	solid	solid	ADJ
admet-661	259	21	phase	phase	NOUN
admet-661	259	22	was	be	AUX
admet-661	259	23	the	the	DET
admet-661	259	24	free	free	ADJ
admet-661	259	25	base	base	NOUN
admet-661	259	26	,	,	PUNCT
admet-661	259	27	and	and	CCONJ
admet-661	259	28	,	,	PUNCT
admet-661	259	29	although	although	SCONJ
admet-661	259	30	the	the	DET
admet-661	259	31	cocrystals	cocrystal	NOUN
admet-661	259	32	crystallized	crystallize	VERB
admet-661	259	33	out	out	ADP
admet-661	259	34	of	of	ADP
admet-661	259	35	solutions	solution	NOUN
admet-661	259	36	upon	upon	SCONJ
admet-661	259	37	further	far	ADV
admet-661	259	38	lowering	lower	VERB
admet-661	259	39	of	of	ADP
admet-661	259	40	ph	ph	NOUN
admet-661	259	41	,	,	PUNCT
admet-661	259	42	the	the	DET
admet-661	259	43	undissolved	undissolve	VERB
admet-661	259	44	free	free	ADJ
admet-661	259	45	base	base	NOUN
admet-661	259	46	did	do	AUX
admet-661	259	47	not	not	PART
admet-661	259	48	readily	readily	ADV
admet-661	259	49	convert	convert	VERB
admet-661	259	50	to	to	ADP
admet-661	259	51	cocrystals	cocrystal	NOUN
admet-661	259	52	and	and	CCONJ
admet-661	259	53	formed	form	VERB
admet-661	259	54	physical	physical	ADJ
admet-661	259	55	mixtures	mixture	NOUN
admet-661	259	56	with	with	ADP
admet-661	259	57	cocrystals	cocrystal	NOUN
admet-661	259	58	.	.	PUNCT
admet-661	260	1	however	however	ADV
admet-661	260	2	,	,	PUNCT
admet-661	260	3	upon	upon	SCONJ
admet-661	260	4	further	further	ADJ
admet-661	260	5	addition	addition	NOUN
admet-661	260	6	of	of	ADP
admet-661	260	7	fumaric	fumaric	ADJ
admet-661	260	8	acid	acid	PROPN
admet-661	260	9	or	or	CCONJ
admet-661	260	10	succinic	succinic	ADJ
admet-661	260	11	acid	acid	NOUN
admet-661	260	12	to	to	PART
admet-661	260	13	decrease	decrease	VERB
admet-661	260	14	ph	ph	PROPN
admet-661	260	15	,	,	PUNCT
admet-661	260	16	the	the	DET
admet-661	260	17	free	free	ADJ
admet-661	260	18	base	base	NOUN
admet-661	260	19	in	in	ADP
admet-661	260	20	the	the	DET
admet-661	260	21	solid	solid	ADJ
admet-661	260	22	phase	phase	NOUN
admet-661	260	23	gradually	gradually	ADV
admet-661	260	24	decreased	decrease	VERB
admet-661	260	25	and	and	CCONJ
admet-661	260	26	the	the	DET
admet-661	260	27	solid	solid	ADJ
admet-661	260	28	converted	convert	VERB
admet-661	260	29	fully	fully	ADV
admet-661	260	30	to	to	ADP
admet-661	260	31	cocrystals	cocrystal	NOUN
admet-661	260	32	.	.	PUNCT
admet-661	261	1	the	the	DET
admet-661	261	2	ph	ph	PROPN
admet-661	261	3	versus	versus	ADP
admet-661	261	4	solubility	solubility	NOUN
admet-661	261	5	profile	profile	NOUN
admet-661	261	6	of	of	ADP
admet-661	261	7	ketoconazole	ketoconazole	NOUN
admet-661	261	8	as	as	SCONJ
admet-661	261	9	determined	determine	VERB
admet-661	261	10	by	by	ADP
admet-661	261	11	lowering	lower	VERB
admet-661	261	12	the	the	DET
admet-661	261	13	ph	ph	NOUN
admet-661	261	14	of	of	ADP
admet-661	261	15	free	free	ADJ
admet-661	261	16	base	base	NOUN
admet-661	261	17	with	with	ADP
admet-661	261	18	hcl	hcl	PROPN
admet-661	261	19	,	,	PUNCT
admet-661	261	20	as	as	SCONJ
admet-661	261	21	shown	show	VERB
admet-661	261	22	earlier	early	ADV
admet-661	261	23	in	in	ADP
admet-661	261	24	fig	fig	NOUN
admet-661	261	25	.	.	PUNCT
admet-661	262	1	4	4	NUM
admet-661	262	2	,	,	PUNCT
admet-661	262	3	is	be	AUX
admet-661	262	4	also	also	ADV
admet-661	262	5	partially	partially	ADV
admet-661	262	6	superimposed	superimpose	VERB
admet-661	262	7	in	in	ADP
admet-661	262	8	figs	fig	NOUN
admet-661	262	9	.	.	PUNCT
admet-661	263	1	6	6	NUM
admet-661	263	2	and	and	CCONJ
admet-661	263	3	7	7	NUM
admet-661	263	4	for	for	ADP
admet-661	263	5	vasoya	vasoya	PROPN
admet-661	263	6	et	et	PROPN
admet-661	263	7	al	al	PROPN
admet-661	263	8	.	.	PROPN
admet-661	263	9	admet	admet	PROPN
admet-661	263	10	&	&	CCONJ
admet-661	263	11	dmpk	dmpk	PROPN
admet-661	263	12	7(2	7(2	NUM
admet-661	263	13	)	)	PUNCT
admet-661	263	14	(	(	PUNCT
admet-661	263	15	2019	2019	NUM
admet-661	263	16	)	)	PUNCT
admet-661	263	17	106	106	NUM
admet-661	263	18	-	-	SYM
admet-661	263	19	130	130	NUM
admet-661	263	20	120	120	NUM
admet-661	263	21	comparison	comparison	NOUN
admet-661	263	22	.	.	PUNCT
admet-661	264	1	it	it	PRON
admet-661	264	2	is	be	AUX
admet-661	264	3	evident	evident	ADJ
admet-661	264	4	that	that	SCONJ
admet-661	264	5	until	until	ADP
admet-661	264	6	the	the	DET
admet-661	264	7	onset	onset	NOUN
admet-661	264	8	of	of	ADP
admet-661	264	9	cocrystal	cocrystal	ADJ
admet-661	264	10	formation	formation	NOUN
admet-661	264	11	(	(	PUNCT
admet-661	264	12	i.e	i.e	X
admet-661	264	13	,	,	PUNCT
admet-661	264	14	above	above	ADP
admet-661	264	15	the	the	DET
admet-661	264	16	phmax	phmax	NOUN
admet-661	264	17	)	)	PUNCT
admet-661	264	18	,	,	PUNCT
admet-661	264	19	ph	ph	ADJ
admet-661	264	20	-	-	PUNCT
admet-661	264	21	solubility	solubility	NOUN
admet-661	264	22	profiles	profile	NOUN
admet-661	264	23	were	be	AUX
admet-661	264	24	similar	similar	ADJ
admet-661	264	25	whether	whether	SCONJ
admet-661	264	26	they	they	PRON
admet-661	264	27	were	be	AUX
admet-661	264	28	determined	determine	VERB
admet-661	264	29	by	by	ADP
admet-661	264	30	adjusting	adjust	VERB
admet-661	264	31	ph	ph	PROPN
admet-661	264	32	with	with	ADP
admet-661	264	33	fumaric	fumaric	ADJ
admet-661	264	34	acid	acid	NOUN
admet-661	264	35	,	,	PUNCT
admet-661	264	36	succinic	succinic	ADJ
admet-661	264	37	acid	acid	NOUN
admet-661	264	38	or	or	CCONJ
admet-661	264	39	hcl	hcl	PROPN
admet-661	264	40	.	.	PUNCT
admet-661	265	1	the	the	DET
admet-661	265	2	solubility	solubility	NOUN
admet-661	265	3	is	be	AUX
admet-661	265	4	also	also	ADV
admet-661	265	5	similar	similar	ADJ
admet-661	265	6	to	to	ADP
admet-661	265	7	that	that	PRON
admet-661	265	8	shown	show	VERB
admet-661	265	9	in	in	ADP
admet-661	265	10	fig	fig	NOUN
admet-661	265	11	.	.	PUNCT
admet-661	266	1	5	5	NUM
admet-661	266	2	by	by	ADP
admet-661	266	3	increasing	increase	VERB
admet-661	266	4	ph	ph	NOUN
admet-661	266	5	of	of	ADP
admet-661	266	6	cocrystal	cocrystal	ADJ
admet-661	266	7	solutions	solution	NOUN
admet-661	266	8	with	with	ADP
admet-661	266	9	naoh	naoh	NOUN
admet-661	266	10	.	.	PUNCT
admet-661	267	1	thus	thus	ADV
admet-661	267	2	,	,	PUNCT
admet-661	267	3	the	the	DET
admet-661	267	4	solubility	solubility	NOUN
admet-661	267	5	above	above	ADP
admet-661	267	6	phmax	phmax	PROPN
admet-661	267	7	was	be	AUX
admet-661	267	8	the	the	DET
admet-661	267	9	same	same	ADJ
admet-661	267	10	for	for	ADP
admet-661	267	11	free	free	ADJ
admet-661	267	12	base	base	NOUN
admet-661	267	13	and	and	CCONJ
admet-661	267	14	cocrystal	cocrystal	ADJ
admet-661	267	15	and	and	CCONJ
admet-661	267	16	there	there	PRON
admet-661	267	17	was	be	VERB
admet-661	267	18	no	no	DET
admet-661	267	19	special	special	ADJ
admet-661	267	20	influence	influence	NOUN
admet-661	267	21	of	of	ADP
admet-661	267	22	cocrystal	cocrystal	ADJ
admet-661	267	23	formation	formation	NOUN
admet-661	267	24	.	.	PUNCT
admet-661	268	1	figure	figure	VERB
admet-661	268	2	6	6	NUM
admet-661	268	3	.	.	PUNCT
admet-661	269	1	the	the	DET
admet-661	269	2	ph	ph	VERB
admet-661	269	3	-	-	PUNCT
admet-661	269	4	solubility	solubility	NOUN
admet-661	269	5	profile	profile	NOUN
admet-661	269	6	of	of	ADP
admet-661	269	7	ketoconazole	ketoconazole	NOUN
admet-661	269	8	determined	determine	VERB
admet-661	269	9	by	by	ADP
admet-661	269	10	using	use	VERB
admet-661	269	11	different	different	ADJ
admet-661	269	12	amounts	amount	NOUN
admet-661	269	13	of	of	ADP
admet-661	269	14	1:1	1:1	NUM
admet-661	269	15	molar	molar	ADJ
admet-661	269	16	physical	physical	ADJ
admet-661	269	17	mixtures	mixture	NOUN
admet-661	269	18	of	of	ADP
admet-661	269	19	ketoconazole	ketoconazole	NOUN
admet-661	269	20	and	and	CCONJ
admet-661	269	21	fumaric	fumaric	ADJ
admet-661	269	22	acid	acid	PROPN
admet-661	269	23	and	and	CCONJ
admet-661	269	24	equilibrating	equilibrate	VERB
admet-661	269	25	for	for	ADP
admet-661	269	26	96	96	NUM
admet-661	269	27	h.	h.	NOUN
admet-661	269	28	the	the	DET
admet-661	269	29	ph	ph	VERB
admet-661	269	30	-	-	PUNCT
admet-661	269	31	solubility	solubility	NOUN
admet-661	269	32	profile	profile	NOUN
admet-661	269	33	of	of	ADP
admet-661	269	34	ketoconazole	ketoconazole	NOUN
admet-661	269	35	determined	determine	VERB
admet-661	269	36	by	by	ADP
admet-661	269	37	ph	ph	ADJ
admet-661	269	38	adjustment	adjustment	NOUN
admet-661	269	39	with	with	ADP
admet-661	269	40	hcl	hcl	PROPN
admet-661	269	41	is	be	AUX
admet-661	269	42	also	also	ADV
admet-661	269	43	superimposed	superimpose	VERB
admet-661	269	44	for	for	ADP
admet-661	269	45	comparison	comparison	NOUN
admet-661	269	46	.	.	PUNCT
admet-661	270	1	the	the	DET
admet-661	270	2	solubility	solubility	NOUN
admet-661	270	3	profiles	profile	NOUN
admet-661	270	4	from	from	ADP
admet-661	270	5	a	a	DET
admet-661	270	6	narrow	narrow	ADJ
admet-661	270	7	ph	ph	ADJ
admet-661	270	8	range	range	NOUN
admet-661	270	9	(	(	PUNCT
admet-661	270	10	boxed	boxed	ADJ
admet-661	270	11	region	region	NOUN
admet-661	270	12	)	)	PUNCT
admet-661	270	13	is	be	AUX
admet-661	270	14	shown	show	VERB
admet-661	270	15	in	in	ADP
admet-661	270	16	expanded	expand	VERB
admet-661	270	17	scale	scale	NOUN
admet-661	270	18	in	in	ADP
admet-661	270	19	the	the	DET
admet-661	270	20	inset	inset	NOUN
admet-661	270	21	to	to	PART
admet-661	270	22	indicate	indicate	VERB
admet-661	270	23	decrease	decrease	NOUN
admet-661	270	24	in	in	ADP
admet-661	270	25	ketoconazole	ketoconazole	PROPN
admet-661	270	26	solubility	solubility	NOUN
admet-661	270	27	after	after	SCONJ
admet-661	270	28	conversion	conversion	NOUN
admet-661	270	29	to	to	PART
admet-661	270	30	cocrystal	cocrystal	VERB
admet-661	270	31	during	during	ADP
admet-661	270	32	dissolution	dissolution	NOUN
admet-661	270	33	of	of	ADP
admet-661	270	34	the	the	DET
admet-661	270	35	physical	physical	ADJ
admet-661	270	36	mixture	mixture	NOUN
admet-661	270	37	.	.	PUNCT
admet-661	271	1	asterisk	asterisk	NOUN
admet-661	271	2	symbols	symbol	NOUN
admet-661	271	3	in	in	ADP
admet-661	271	4	the	the	DET
admet-661	271	5	figure	figure	NOUN
admet-661	271	6	indicates	indicate	VERB
admet-661	271	7	solubility	solubility	NOUN
admet-661	271	8	where	where	SCONJ
admet-661	271	9	both	both	DET
admet-661	271	10	ketoconazole	ketoconazole	NOUN
admet-661	271	11	and	and	CCONJ
admet-661	271	12	its	its	PRON
admet-661	271	13	cocrystal	cocrystal	NOUN
admet-661	271	14	with	with	ADP
admet-661	271	15	fumaric	fumaric	ADJ
admet-661	271	16	acid	acid	PROPN
admet-661	271	17	coexist	coexist	NOUN
admet-661	271	18	in	in	ADP
admet-661	271	19	the	the	DET
admet-661	271	20	solid	solid	ADJ
admet-661	271	21	phase	phase	NOUN
admet-661	271	22	.	.	PUNCT
admet-661	272	1	figure	figure	NOUN
admet-661	272	2	7	7	NUM
admet-661	272	3	.	.	PUNCT
admet-661	273	1	the	the	DET
admet-661	273	2	ph	ph	VERB
admet-661	273	3	-	-	PUNCT
admet-661	273	4	solubility	solubility	NOUN
admet-661	273	5	profile	profile	NOUN
admet-661	273	6	of	of	ADP
admet-661	273	7	ketoconazole	ketoconazole	NOUN
admet-661	273	8	determined	determine	VERB
admet-661	273	9	by	by	ADP
admet-661	273	10	using	use	VERB
admet-661	273	11	different	different	ADJ
admet-661	273	12	amounts	amount	NOUN
admet-661	273	13	of	of	ADP
admet-661	273	14	1:1	1:1	NUM
admet-661	273	15	molar	molar	ADJ
admet-661	273	16	physical	physical	ADJ
admet-661	273	17	mixtures	mixture	NOUN
admet-661	273	18	of	of	ADP
admet-661	273	19	ketoconazole	ketoconazole	NOUN
admet-661	273	20	and	and	CCONJ
admet-661	273	21	succinic	succinic	ADJ
admet-661	273	22	acid	acid	NOUN
admet-661	273	23	and	and	CCONJ
admet-661	273	24	equilibrating	equilibrate	VERB
admet-661	273	25	for	for	ADP
admet-661	273	26	96	96	NUM
admet-661	273	27	h.	h.	NOUN
admet-661	273	28	the	the	DET
admet-661	273	29	ph	ph	VERB
admet-661	273	30	-	-	PUNCT
admet-661	273	31	solubility	solubility	NOUN
admet-661	273	32	profile	profile	NOUN
admet-661	273	33	of	of	ADP
admet-661	273	34	ketoconazole	ketoconazole	NOUN
admet-661	273	35	determined	determine	VERB
admet-661	273	36	by	by	ADP
admet-661	273	37	ph	ph	ADJ
admet-661	273	38	adjustment	adjustment	NOUN
admet-661	273	39	with	with	ADP
admet-661	273	40	hcl	hcl	PROPN
admet-661	273	41	is	be	AUX
admet-661	273	42	also	also	ADV
admet-661	273	43	superimposed	superimpose	VERB
admet-661	273	44	for	for	ADP
admet-661	273	45	comparison	comparison	NOUN
admet-661	273	46	.	.	PUNCT
admet-661	274	1	the	the	DET
admet-661	274	2	solubility	solubility	NOUN
admet-661	274	3	profiles	profile	NOUN
admet-661	274	4	from	from	ADP
admet-661	274	5	a	a	DET
admet-661	274	6	narrow	narrow	ADJ
admet-661	274	7	ph	ph	ADJ
admet-661	274	8	range	range	NOUN
admet-661	274	9	(	(	PUNCT
admet-661	274	10	boxed	boxed	ADJ
admet-661	274	11	region	region	NOUN
admet-661	274	12	)	)	PUNCT
admet-661	274	13	is	be	AUX
admet-661	274	14	shown	show	VERB
admet-661	274	15	in	in	ADP
admet-661	274	16	expanded	expand	VERB
admet-661	274	17	scale	scale	NOUN
admet-661	274	18	in	in	ADP
admet-661	274	19	the	the	DET
admet-661	274	20	inset	inset	NOUN
admet-661	274	21	to	to	PART
admet-661	274	22	indicate	indicate	VERB
admet-661	274	23	decrease	decrease	NOUN
admet-661	274	24	in	in	ADP
admet-661	274	25	ketoconazole	ketoconazole	PROPN
admet-661	274	26	solubility	solubility	NOUN
admet-661	274	27	after	after	SCONJ
admet-661	274	28	conversion	conversion	NOUN
admet-661	274	29	to	to	PART
admet-661	274	30	cocrystal	cocrystal	VERB
admet-661	274	31	during	during	ADP
admet-661	274	32	dissolution	dissolution	NOUN
admet-661	274	33	of	of	ADP
admet-661	274	34	the	the	DET
admet-661	274	35	physical	physical	ADJ
admet-661	274	36	mixture	mixture	NOUN
admet-661	274	37	.	.	PUNCT
admet-661	275	1	asterisk	asterisk	NOUN
admet-661	275	2	symbols	symbol	NOUN
admet-661	275	3	in	in	ADP
admet-661	275	4	the	the	DET
admet-661	275	5	figure	figure	NOUN
admet-661	275	6	indicates	indicate	VERB
admet-661	275	7	solubility	solubility	NOUN
admet-661	275	8	where	where	SCONJ
admet-661	275	9	both	both	PRON
admet-661	275	10	ketoconazole	ketoconazole	NOUN
admet-661	275	11	and	and	CCONJ
admet-661	275	12	ketoconazole	ketoconazole	NOUN
admet-661	275	13	-	-	PUNCT
admet-661	275	14	succinic	succinic	ADJ
admet-661	275	15	acid	acid	NOUN
admet-661	275	16	cocrystals	cocrystal	NOUN
admet-661	275	17	coexist	coexist	VERB
admet-661	275	18	in	in	ADP
admet-661	275	19	the	the	DET
admet-661	275	20	solid	solid	ADJ
admet-661	275	21	phase	phase	NOUN
admet-661	275	22	.	.	PUNCT
admet-661	276	1	effect	effect	NOUN
admet-661	276	2	of	of	ADP
admet-661	276	3	equilibration	equilibration	NOUN
admet-661	276	4	time	time	NOUN
admet-661	276	5	on	on	ADP
admet-661	276	6	ketoconazole	ketoconazole	PROPN
admet-661	276	7	solubility	solubility	NOUN
admet-661	276	8	and	and	CCONJ
admet-661	276	9	its	its	PRON
admet-661	276	10	conversion	conversion	NOUN
admet-661	276	11	to	to	PART
admet-661	276	12	cocrystals	cocrystal	VERB
admet-661	276	13	the	the	DET
admet-661	276	14	conversion	conversion	NOUN
admet-661	276	15	of	of	ADP
admet-661	276	16	ketoconazole	ketoconazole	NOUN
admet-661	276	17	to	to	ADP
admet-661	276	18	a	a	DET
admet-661	276	19	cocrystal	cocrystal	NOUN
admet-661	276	20	in	in	ADP
admet-661	276	21	the	the	DET
admet-661	276	22	solid	solid	ADJ
admet-661	276	23	phase	phase	NOUN
admet-661	276	24	during	during	ADP
admet-661	276	25	the	the	DET
admet-661	276	26	determination	determination	NOUN
admet-661	276	27	of	of	ADP
admet-661	276	28	phsolubility	phsolubility	NOUN
admet-661	276	29	profile	profile	NOUN
admet-661	276	30	was	be	AUX
admet-661	276	31	a	a	DET
admet-661	276	32	slow	slow	ADJ
admet-661	276	33	process	process	NOUN
admet-661	276	34	.	.	PUNCT
admet-661	277	1	as	as	SCONJ
admet-661	277	2	mentioned	mention	VERB
admet-661	277	3	in	in	ADP
admet-661	277	4	the	the	DET
admet-661	277	5	experimental	experimental	ADJ
admet-661	277	6	section	section	NOUN
admet-661	277	7	,	,	PUNCT
admet-661	277	8	the	the	DET
admet-661	277	9	solubility	solubility	NOUN
admet-661	277	10	was	be	AUX
admet-661	277	11	determined	determine	VERB
admet-661	277	12	by	by	ADP
admet-661	277	13	equilibrating	equilibrate	VERB
admet-661	277	14	solutions	solution	NOUN
admet-661	277	15	for	for	ADP
admet-661	277	16	4	4	NUM
admet-661	277	17	,	,	PUNCT
admet-661	277	18	24	24	NUM
admet-661	277	19	and	and	CCONJ
admet-661	277	20	96	96	NUM
admet-661	277	21	h	h	NOUN
admet-661	277	22	by	by	ADP
admet-661	277	23	shaking	shake	VERB
admet-661	277	24	aqueous	aqueous	ADJ
admet-661	277	25	media	medium	NOUN
admet-661	277	26	with	with	ADP
admet-661	277	27	excess	excess	ADJ
admet-661	277	28	solids	solid	NOUN
admet-661	277	29	,	,	PUNCT
admet-661	277	30	and	and	CCONJ
admet-661	277	31	when	when	SCONJ
admet-661	277	32	suspensions	suspension	NOUN
admet-661	277	33	with	with	ADP
admet-661	277	34	excess	excess	ADJ
admet-661	277	35	1:1	1:1	NUM
admet-661	277	36	molar	molar	ADJ
admet-661	277	37	mixture	mixture	NOUN
admet-661	277	38	of	of	ADP
admet-661	277	39	ketoconazole	ketoconazole	NOUN
admet-661	277	40	and	and	CCONJ
admet-661	277	41	acids	acid	NOUN
admet-661	277	42	(	(	PUNCT
admet-661	277	43	coformers	coformer	NOUN
admet-661	277	44	)	)	PUNCT
admet-661	277	45	at	at	ADP
admet-661	277	46	or	or	CCONJ
admet-661	277	47	below	below	ADP
admet-661	277	48	phmax	phmax	NOUN
admet-661	277	49	were	be	AUX
admet-661	277	50	equilibrated	equilibrate	VERB
admet-661	277	51	for	for	ADP
admet-661	277	52	4h	4h	NUM
admet-661	277	53	,	,	PUNCT
admet-661	277	54	the	the	DET
admet-661	277	55	solid	solid	ADJ
admet-661	277	56	phase	phase	NOUN
admet-661	277	57	was	be	AUX
admet-661	277	58	the	the	DET
admet-661	277	59	free	free	ADJ
admet-661	277	60	base	base	NOUN
admet-661	277	61	and	and	CCONJ
admet-661	277	62	no	no	DET
admet-661	277	63	conversion	conversion	NOUN
admet-661	277	64	to	to	PART
admet-661	277	65	cocrystal	cocrystal	VERB
admet-661	277	66	was	be	AUX
admet-661	277	67	observed	observe	VERB
admet-661	277	68	.	.	PUNCT
admet-661	278	1	at	at	ADP
admet-661	278	2	24	24	NUM
admet-661	278	3	h	h	NOUN
admet-661	278	4	,	,	PUNCT
admet-661	278	5	the	the	DET
admet-661	278	6	solid	solid	ADJ
admet-661	278	7	phase	phase	NOUN
admet-661	278	8	in	in	ADP
admet-661	278	9	some	some	PRON
admet-661	278	10	of	of	ADP
admet-661	278	11	the	the	DET
admet-661	278	12	suspensions	suspension	NOUN
admet-661	278	13	was	be	AUX
admet-661	278	14	the	the	DET
admet-661	278	15	mixture	mixture	NOUN
admet-661	278	16	of	of	ADP
admet-661	278	17	free	free	ADJ
admet-661	278	18	base	base	NOUN
admet-661	278	19	and	and	CCONJ
admet-661	278	20	cocrystal	cocrystal	NOUN
admet-661	278	21	,	,	PUNCT
admet-661	278	22	and	and	CCONJ
admet-661	278	23	the	the	DET
admet-661	278	24	saturation	saturation	NOUN
admet-661	278	25	solubility	solubility	NOUN
admet-661	278	26	was	be	AUX
admet-661	278	27	not	not	PART
admet-661	278	28	consistently	consistently	ADV
admet-661	278	29	the	the	DET
admet-661	278	30	same	same	ADJ
admet-661	278	31	when	when	SCONJ
admet-661	278	32	the	the	DET
admet-661	278	33	experiments	experiment	NOUN
admet-661	278	34	were	be	AUX
admet-661	278	35	repeated	repeat	VERB
admet-661	278	36	,	,	PUNCT
admet-661	278	37	indicating	indicate	VERB
admet-661	278	38	that	that	SCONJ
admet-661	278	39	admet	admet	PROPN
admet-661	278	40	&	&	CCONJ
admet-661	278	41	dmpk	dmpk	PROPN
admet-661	278	42	7(2	7(2	NUM
admet-661	278	43	)	)	PUNCT
admet-661	278	44	(	(	PUNCT
admet-661	278	45	2019	2019	NUM
admet-661	278	46	)	)	PUNCT
admet-661	278	47	106	106	NUM
admet-661	278	48	-	-	SYM
admet-661	278	49	130	130	NUM
admet-661	278	50	solubility	solubility	NOUN
admet-661	278	51	and	and	CCONJ
admet-661	278	52	dissolution	dissolution	NOUN
admet-661	278	53	of	of	ADP
admet-661	278	54	cocrystals	cocrystal	NOUN
admet-661	278	55	doi	doi	NOUN
admet-661	278	56	:	:	PUNCT
admet-661	278	57	10.5599	10.5599	NUM
admet-661	278	58	/	/	SYM
admet-661	278	59	admet.661	admet.661	PROPN
admet-661	278	60	121	121	NUM
admet-661	278	61	the	the	DET
admet-661	278	62	systems	system	NOUN
admet-661	278	63	did	do	AUX
admet-661	278	64	not	not	PART
admet-661	278	65	reach	reach	VERB
admet-661	278	66	equilibria	equilibrium	NOUN
admet-661	278	67	.	.	PUNCT
admet-661	279	1	the	the	DET
admet-661	279	2	conversion	conversion	NOUN
admet-661	279	3	of	of	ADP
admet-661	279	4	free	free	ADJ
admet-661	279	5	base	base	NOUN
admet-661	279	6	to	to	PART
admet-661	279	7	cocrystal	cocrystal	VERB
admet-661	279	8	was	be	AUX
admet-661	279	9	also	also	ADV
admet-661	279	10	influenced	influence	VERB
admet-661	279	11	by	by	ADP
admet-661	279	12	how	how	SCONJ
admet-661	279	13	much	much	ADJ
admet-661	279	14	excess	excess	ADJ
admet-661	279	15	solid	solid	ADJ
admet-661	279	16	was	be	AUX
admet-661	279	17	present	present	ADJ
admet-661	279	18	in	in	ADP
admet-661	279	19	the	the	DET
admet-661	279	20	system	system	NOUN
admet-661	279	21	;	;	PUNCT
admet-661	279	22	the	the	DET
admet-661	279	23	conversion	conversion	NOUN
admet-661	279	24	to	to	PART
admet-661	279	25	cocrystal	cocrystal	VERB
admet-661	279	26	was	be	AUX
admet-661	279	27	faster	fast	ADJ
admet-661	279	28	as	as	SCONJ
admet-661	279	29	larger	large	ADJ
admet-661	279	30	amounts	amount	NOUN
admet-661	279	31	of	of	ADP
admet-661	279	32	excess	excess	ADJ
admet-661	279	33	solids	solid	NOUN
admet-661	279	34	were	be	AUX
admet-661	279	35	added	add	VERB
admet-661	279	36	during	during	ADP
admet-661	279	37	the	the	DET
admet-661	279	38	determination	determination	NOUN
admet-661	279	39	of	of	ADP
admet-661	279	40	solubility	solubility	NOUN
admet-661	279	41	.	.	PUNCT
admet-661	280	1	for	for	ADP
admet-661	280	2	these	these	DET
admet-661	280	3	reasons	reason	NOUN
admet-661	280	4	,	,	PUNCT
admet-661	280	5	the	the	DET
admet-661	280	6	equilibration	equilibration	NOUN
admet-661	280	7	period	period	NOUN
admet-661	280	8	was	be	AUX
admet-661	280	9	increased	increase	VERB
admet-661	280	10	to	to	ADP
admet-661	280	11	96	96	NUM
admet-661	280	12	h	h	NOUN
admet-661	280	13	,	,	PUNCT
admet-661	280	14	when	when	SCONJ
admet-661	280	15	consistent	consistent	ADJ
admet-661	280	16	results	result	VERB
admet-661	280	17	with	with	ADP
admet-661	280	18	respect	respect	NOUN
admet-661	280	19	to	to	ADP
admet-661	280	20	both	both	DET
admet-661	280	21	solubility	solubility	NOUN
admet-661	280	22	and	and	CCONJ
admet-661	280	23	conversion	conversion	NOUN
admet-661	280	24	to	to	ADP
admet-661	280	25	cocrystals	cocrystal	NOUN
admet-661	280	26	were	be	AUX
admet-661	280	27	obtained	obtain	VERB
admet-661	280	28	.	.	PUNCT
admet-661	281	1	it	it	PRON
admet-661	281	2	may	may	AUX
admet-661	281	3	be	be	AUX
admet-661	281	4	mentioned	mention	VERB
admet-661	281	5	here	here	ADV
admet-661	281	6	that	that	SCONJ
admet-661	281	7	,	,	PUNCT
admet-661	281	8	in	in	ADP
admet-661	281	9	separate	separate	ADJ
admet-661	281	10	experiments	experiment	NOUN
admet-661	281	11	,	,	PUNCT
admet-661	281	12	we	we	PRON
admet-661	281	13	observed	observe	VERB
admet-661	281	14	that	that	SCONJ
admet-661	281	15	1:1	1:1	NUM
admet-661	281	16	physical	physical	ADJ
admet-661	281	17	mixtures	mixture	NOUN
admet-661	281	18	of	of	ADP
admet-661	281	19	ketoconazole	ketoconazole	NOUN
admet-661	281	20	with	with	ADP
admet-661	281	21	coformers	coformer	NOUN
admet-661	281	22	can	can	AUX
admet-661	281	23	be	be	AUX
admet-661	281	24	converted	convert	VERB
admet-661	281	25	immediately	immediately	ADV
admet-661	281	26	and	and	CCONJ
admet-661	281	27	completely	completely	ADV
admet-661	281	28	to	to	ADP
admet-661	281	29	cocrystals	cocrystal	NOUN
admet-661	281	30	by	by	ADP
admet-661	281	31	cogrinding	cogrinde	VERB
admet-661	281	32	with	with	ADP
admet-661	281	33	the	the	DET
admet-661	281	34	addition	addition	NOUN
admet-661	281	35	of	of	ADP
admet-661	281	36	a	a	DET
admet-661	281	37	small	small	ADJ
admet-661	281	38	amount	amount	NOUN
admet-661	281	39	of	of	ADP
admet-661	281	40	water	water	NOUN
admet-661	281	41	.	.	PUNCT
admet-661	282	1	thus	thus	ADV
admet-661	282	2	,	,	PUNCT
admet-661	282	3	the	the	DET
admet-661	282	4	conversion	conversion	NOUN
admet-661	282	5	of	of	ADP
admet-661	282	6	the	the	DET
admet-661	282	7	solid	solid	ADJ
admet-661	282	8	mixtures	mixture	NOUN
admet-661	282	9	to	to	ADP
admet-661	282	10	cocrystals	cocrystal	NOUN
admet-661	282	11	appears	appear	VERB
admet-661	282	12	to	to	PART
admet-661	282	13	be	be	AUX
admet-661	282	14	dependent	dependent	ADJ
admet-661	282	15	on	on	ADP
admet-661	282	16	the	the	DET
admet-661	282	17	proximity	proximity	NOUN
admet-661	282	18	of	of	ADP
admet-661	282	19	ketoconazole	ketoconazole	NOUN
admet-661	282	20	and	and	CCONJ
admet-661	282	21	the	the	DET
admet-661	282	22	coformer	coformer	NOUN
admet-661	282	23	and	and	CCONJ
admet-661	282	24	how	how	SCONJ
admet-661	282	25	intimately	intimately	ADV
admet-661	282	26	they	they	PRON
admet-661	282	27	are	be	AUX
admet-661	282	28	mixed	mixed	ADJ
admet-661	282	29	.	.	PUNCT
admet-661	283	1	figure	figure	NOUN
admet-661	283	2	8	8	NUM
admet-661	283	3	.	.	PUNCT
admet-661	284	1	ph	ph	ADJ
admet-661	284	2	-	-	PUNCT
admet-661	284	3	solubility	solubility	NOUN
admet-661	284	4	profiles	profile	NOUN
admet-661	284	5	of	of	ADP
admet-661	284	6	ketoconazole	ketoconazole	NOUN
admet-661	284	7	-	-	PUNCT
admet-661	284	8	fumaric	fumaric	ADJ
admet-661	284	9	acid	acid	PROPN
admet-661	284	10	physical	physical	ADJ
admet-661	284	11	mixtures	mixture	NOUN
admet-661	284	12	after	after	ADP
admet-661	284	13	equilibration	equilibration	NOUN
admet-661	284	14	for	for	ADP
admet-661	284	15	4	4	NUM
admet-661	284	16	and	and	CCONJ
admet-661	284	17	96	96	NUM
admet-661	284	18	h.	h.	NOUN
admet-661	284	19	asterisk	asterisk	PROPN
admet-661	284	20	symbols	symbol	NOUN
admet-661	284	21	in	in	ADP
admet-661	284	22	the	the	DET
admet-661	284	23	figure	figure	NOUN
admet-661	284	24	indicates	indicate	VERB
admet-661	284	25	solubility	solubility	NOUN
admet-661	284	26	where	where	SCONJ
admet-661	284	27	both	both	PRON
admet-661	284	28	ketoconazole	ketoconazole	NOUN
admet-661	284	29	and	and	CCONJ
admet-661	284	30	ketoconazole	ketoconazole	NOUN
admet-661	284	31	-	-	PUNCT
admet-661	284	32	fumaric	fumaric	ADJ
admet-661	284	33	acid	acid	PROPN
admet-661	284	34	cocrystal	cocrystal	PROPN
admet-661	284	35	coexist	coexist	VERB
admet-661	284	36	in	in	ADP
admet-661	284	37	the	the	DET
admet-661	284	38	solid	solid	ADJ
admet-661	284	39	phase	phase	NOUN
admet-661	284	40	.	.	PUNCT
admet-661	285	1	to	to	PART
admet-661	285	2	demonstrate	demonstrate	VERB
admet-661	285	3	the	the	DET
admet-661	285	4	effect	effect	NOUN
admet-661	285	5	of	of	ADP
admet-661	285	6	equilibration	equilibration	NOUN
admet-661	285	7	time	time	NOUN
admet-661	285	8	on	on	ADP
admet-661	285	9	the	the	DET
admet-661	285	10	solubility	solubility	NOUN
admet-661	285	11	of	of	ADP
admet-661	285	12	ketoconazole	ketoconazole	NOUN
admet-661	285	13	,	,	PUNCT
admet-661	285	14	ph	ph	ADJ
admet-661	285	15	-	-	PUNCT
admet-661	285	16	solubility	solubility	NOUN
admet-661	285	17	profiles	profile	NOUN
admet-661	285	18	of	of	ADP
admet-661	285	19	ketoconazole	ketoconazole	NOUN
admet-661	285	20	after	after	ADP
admet-661	285	21	equilibration	equilibration	NOUN
admet-661	285	22	with	with	ADP
admet-661	285	23	fumaric	fumaric	ADJ
admet-661	285	24	acid	acid	NOUN
admet-661	285	25	for	for	ADP
admet-661	285	26	4	4	NUM
admet-661	285	27	and	and	CCONJ
admet-661	285	28	96	96	NUM
admet-661	285	29	h	h	NOUN
admet-661	285	30	were	be	AUX
admet-661	285	31	determined	determine	VERB
admet-661	285	32	and	and	CCONJ
admet-661	285	33	the	the	DET
admet-661	285	34	results	result	NOUN
admet-661	285	35	are	be	AUX
admet-661	285	36	given	give	VERB
admet-661	285	37	in	in	ADP
admet-661	285	38	fig	fig	NOUN
admet-661	285	39	.	.	PUNCT
admet-661	286	1	8	8	NUM
admet-661	286	2	.	.	X
admet-661	287	1	in	in	ADP
admet-661	287	2	this	this	DET
admet-661	287	3	figure	figure	NOUN
admet-661	287	4	,	,	PUNCT
admet-661	287	5	the	the	DET
admet-661	287	6	solubility	solubility	NOUN
admet-661	287	7	profile	profile	NOUN
admet-661	287	8	of	of	ADP
admet-661	287	9	ketoconazole	ketoconazole	NOUN
admet-661	287	10	after	after	ADP
admet-661	287	11	equilibration	equilibration	NOUN
admet-661	287	12	with	with	ADP
admet-661	287	13	fumaric	fumaric	ADJ
admet-661	287	14	acid	acid	NOUN
admet-661	287	15	at	at	ADP
admet-661	287	16	each	each	DET
admet-661	287	17	data	datum	NOUN
admet-661	287	18	point	point	NOUN
admet-661	287	19	for	for	ADP
admet-661	287	20	4	4	NUM
admet-661	287	21	h	h	NOUN
admet-661	287	22	is	be	AUX
admet-661	287	23	compared	compare	VERB
admet-661	287	24	with	with	ADP
admet-661	287	25	the	the	DET
admet-661	287	26	solubility	solubility	NOUN
admet-661	287	27	profile	profile	NOUN
admet-661	287	28	after	after	ADP
admet-661	287	29	equilibration	equilibration	NOUN
admet-661	287	30	for	for	ADP
admet-661	287	31	96	96	NUM
admet-661	287	32	h	h	NOUN
admet-661	287	33	that	that	PRON
admet-661	287	34	has	have	AUX
admet-661	287	35	been	be	AUX
admet-661	287	36	shown	show	VERB
admet-661	287	37	earlier	early	ADV
admet-661	287	38	in	in	ADP
admet-661	287	39	fig	fig	NOUN
admet-661	287	40	.	.	PUNCT
admet-661	288	1	7	7	X
admet-661	288	2	.	.	X
admet-661	288	3	the	the	DET
admet-661	288	4	solubility	solubility	NOUN
admet-661	288	5	of	of	ADP
admet-661	288	6	ketoconazole	ketoconazole	NOUN
admet-661	288	7	increased	increase	VERB
admet-661	288	8	gradually	gradually	ADV
admet-661	288	9	and	and	CCONJ
admet-661	288	10	the	the	DET
admet-661	288	11	ph	ph	NOUN
admet-661	288	12	decreased	decrease	VERB
admet-661	288	13	when	when	SCONJ
admet-661	288	14	increasing	increase	VERB
admet-661	288	15	amounts	amount	NOUN
admet-661	288	16	of	of	ADP
admet-661	288	17	1:1	1:1	NUM
admet-661	288	18	ketoconazole	ketoconazole	NOUN
admet-661	288	19	-	-	PUNCT
admet-661	288	20	fumaric	fumaric	ADJ
admet-661	288	21	acid	acid	NOUN
admet-661	288	22	mixture	mixture	NOUN
admet-661	288	23	were	be	AUX
admet-661	288	24	equilibrated	equilibrate	VERB
admet-661	288	25	for	for	ADP
admet-661	288	26	4	4	NUM
admet-661	288	27	h	h	NOUN
admet-661	288	28	at	at	ADP
admet-661	288	29	each	each	DET
admet-661	288	30	time	time	NOUN
admet-661	288	31	point	point	NOUN
admet-661	288	32	.	.	PUNCT
admet-661	289	1	the	the	DET
admet-661	289	2	experiment	experiment	NOUN
admet-661	289	3	was	be	AUX
admet-661	289	4	discontinued	discontinue	VERB
admet-661	289	5	when	when	SCONJ
admet-661	289	6	the	the	DET
admet-661	289	7	solubility	solubility	NOUN
admet-661	289	8	of	of	ADP
admet-661	289	9	ketoconazole	ketoconazole	NOUN
admet-661	289	10	reached	reach	VERB
admet-661	289	11	about	about	ADV
admet-661	289	12	7000	7000	NUM
admet-661	289	13	µg	µg	NOUN
admet-661	289	14	/	/	SYM
admet-661	289	15	ml	ml	NOUN
admet-661	289	16	(	(	PUNCT
admet-661	289	17	7	7	NUM
admet-661	289	18	mg	mg	NUM
admet-661	289	19	/	/	SYM
admet-661	289	20	ml	ml	NOUN
admet-661	289	21	)	)	PUNCT
admet-661	289	22	.	.	PUNCT
admet-661	290	1	there	there	PRON
admet-661	290	2	was	be	VERB
admet-661	290	3	no	no	DET
admet-661	290	4	conversion	conversion	NOUN
admet-661	290	5	of	of	ADP
admet-661	290	6	the	the	DET
admet-661	290	7	solid	solid	ADJ
admet-661	290	8	phase	phase	NOUN
admet-661	290	9	to	to	ADP
admet-661	290	10	cocrystals	cocrystal	NOUN
admet-661	290	11	at	at	ADP
admet-661	290	12	any	any	PRON
admet-661	290	13	of	of	ADP
admet-661	290	14	the	the	DET
admet-661	290	15	data	data	NOUN
admet-661	290	16	points	point	NOUN
admet-661	290	17	.	.	PUNCT
admet-661	291	1	in	in	ADP
admet-661	291	2	contrast	contrast	NOUN
admet-661	291	3	,	,	PUNCT
admet-661	291	4	the	the	DET
admet-661	291	5	maximum	maximum	ADJ
admet-661	291	6	solubility	solubility	NOUN
admet-661	291	7	of	of	ADP
admet-661	291	8	ketoconazole	ketoconazole	PROPN
admet-661	291	9	base	base	NOUN
admet-661	291	10	observed	observe	VERB
admet-661	291	11	after	after	ADP
admet-661	291	12	equilibration	equilibration	NOUN
admet-661	291	13	for	for	ADP
admet-661	291	14	96	96	NUM
admet-661	291	15	h	h	NOUN
admet-661	291	16	was	be	AUX
admet-661	291	17	about	about	ADV
admet-661	291	18	3000	3000	NUM
admet-661	291	19	µg	µg	NOUN
admet-661	291	20	/	/	SYM
admet-661	291	21	ml	ml	NOUN
admet-661	291	22	(	(	PUNCT
admet-661	291	23	3	3	NUM
admet-661	291	24	mg	mg	NUM
admet-661	291	25	/	/	SYM
admet-661	291	26	ml	ml	NOUN
admet-661	291	27	)	)	PUNCT
admet-661	291	28	at	at	ADP
admet-661	291	29	ph~3.7	ph~3.7	NOUN
admet-661	291	30	and	and	CCONJ
admet-661	291	31	after	after	ADP
admet-661	291	32	that	that	PRON
admet-661	291	33	the	the	DET
admet-661	291	34	solubility	solubility	NOUN
admet-661	291	35	decreased	decrease	VERB
admet-661	291	36	due	due	ADP
admet-661	291	37	to	to	ADP
admet-661	291	38	the	the	DET
admet-661	291	39	crystallization	crystallization	NOUN
admet-661	291	40	of	of	ADP
admet-661	291	41	ketoconazole	ketoconazole	NOUN
admet-661	291	42	-	-	PUNCT
admet-661	291	43	fumaric	fumaric	ADJ
admet-661	291	44	acid	acid	PROPN
admet-661	291	45	cocrystal	cocrystal	PROPN
admet-661	291	46	.	.	PUNCT
admet-661	292	1	it	it	PRON
admet-661	292	2	may	may	AUX
admet-661	292	3	also	also	ADV
admet-661	292	4	be	be	AUX
admet-661	292	5	noticed	notice	VERB
admet-661	292	6	in	in	ADP
admet-661	292	7	fig	fig	NOUN
admet-661	292	8	.	.	PUNCT
admet-661	293	1	8	8	NUM
admet-661	294	1	that	that	SCONJ
admet-661	294	2	there	there	PRON
admet-661	294	3	was	be	VERB
admet-661	294	4	a	a	DET
admet-661	294	5	small	small	ADJ
admet-661	294	6	increase	increase	NOUN
admet-661	294	7	in	in	ADP
admet-661	294	8	ph	ph	NOUN
admet-661	294	9	by	by	ADP
admet-661	294	10	about	about	ADV
admet-661	294	11	0.2	0.2	NUM
admet-661	294	12	unit	unit	NOUN
admet-661	294	13	in	in	ADP
admet-661	294	14	the	the	DET
admet-661	294	15	solubility	solubility	NOUN
admet-661	294	16	profile	profile	NOUN
admet-661	294	17	determined	determine	VERB
admet-661	294	18	by	by	ADP
admet-661	294	19	equilibration	equilibration	NOUN
admet-661	294	20	for	for	ADP
admet-661	294	21	96	96	NUM
admet-661	294	22	h	h	NOUN
admet-661	294	23	as	as	SCONJ
admet-661	294	24	compared	compare	VERB
admet-661	294	25	to	to	ADP
admet-661	294	26	that	that	PRON
admet-661	294	27	for	for	ADP
admet-661	294	28	4	4	NUM
admet-661	294	29	h.	h.	NOUN
admet-661	294	30	the	the	DET
admet-661	294	31	mechanism	mechanism	NOUN
admet-661	294	32	of	of	ADP
admet-661	294	33	this	this	DET
admet-661	294	34	effect	effect	NOUN
admet-661	294	35	was	be	AUX
admet-661	294	36	not	not	PART
admet-661	294	37	investigated	investigate	VERB
admet-661	294	38	;	;	PUNCT
admet-661	294	39	however	however	ADV
admet-661	294	40	,	,	PUNCT
admet-661	294	41	it	it	PRON
admet-661	294	42	could	could	AUX
admet-661	294	43	be	be	AUX
admet-661	294	44	due	due	ADJ
admet-661	294	45	to	to	ADP
admet-661	294	46	complexation	complexation	NOUN
admet-661	294	47	of	of	ADP
admet-661	294	48	fumaric	fumaric	ADJ
admet-661	294	49	acid	acid	PROPN
admet-661	294	50	before	before	ADP
admet-661	294	51	or	or	CCONJ
admet-661	294	52	after	after	ADP
admet-661	294	53	nucleation	nucleation	NOUN
admet-661	294	54	into	into	ADP
admet-661	294	55	cocrystal	cocrystal	ADJ
admet-661	294	56	and	and	CCONJ
admet-661	294	57	thus	thus	ADV
admet-661	294	58	being	be	AUX
admet-661	294	59	unable	unable	ADJ
admet-661	294	60	to	to	PART
admet-661	294	61	act	act	VERB
admet-661	294	62	as	as	ADP
admet-661	294	63	the	the	DET
admet-661	294	64	free	free	ADJ
admet-661	294	65	acid	acid	NOUN
admet-661	294	66	form	form	NOUN
admet-661	294	67	.	.	PUNCT
admet-661	295	1	vasoya	vasoya	PROPN
admet-661	295	2	et	et	PROPN
admet-661	295	3	al	al	PROPN
admet-661	295	4	.	.	PROPN
admet-661	295	5	admet	admet	PROPN
admet-661	295	6	&	&	CCONJ
admet-661	295	7	dmpk	dmpk	PROPN
admet-661	295	8	7(2	7(2	NUM
admet-661	295	9	)	)	PUNCT
admet-661	295	10	(	(	PUNCT
admet-661	295	11	2019	2019	NUM
admet-661	295	12	)	)	PUNCT
admet-661	295	13	106	106	NUM
admet-661	295	14	-	-	SYM
admet-661	295	15	130	130	NUM
admet-661	295	16	122	122	NUM
admet-661	295	17	essentially	essentially	ADV
admet-661	295	18	similar	similar	ADJ
admet-661	295	19	effects	effect	NOUN
admet-661	295	20	of	of	ADP
admet-661	295	21	equilibration	equilibration	NOUN
admet-661	295	22	time	time	NOUN
admet-661	295	23	were	be	AUX
admet-661	295	24	observed	observe	VERB
admet-661	295	25	when	when	SCONJ
admet-661	295	26	succinic	succinic	ADJ
admet-661	295	27	acid	acid	NOUN
admet-661	295	28	was	be	AUX
admet-661	295	29	used	use	VERB
admet-661	295	30	to	to	PART
admet-661	295	31	adjust	adjust	VERB
admet-661	295	32	ph	ph	PROPN
admet-661	295	33	(	(	PUNCT
admet-661	295	34	data	datum	NOUN
admet-661	295	35	not	not	PART
admet-661	295	36	shown	show	VERB
admet-661	295	37	)	)	PUNCT
admet-661	295	38	.	.	PUNCT
admet-661	296	1	these	these	DET
admet-661	296	2	results	result	NOUN
admet-661	296	3	demonstrate	demonstrate	VERB
admet-661	296	4	that	that	SCONJ
admet-661	296	5	equilibrium	equilibrium	NOUN
admet-661	296	6	solubilities	solubility	NOUN
admet-661	296	7	of	of	ADP
admet-661	296	8	free	free	ADJ
admet-661	296	9	base	base	NOUN
admet-661	296	10	and	and	CCONJ
admet-661	296	11	their	their	PRON
admet-661	296	12	cocrystals	cocrystal	NOUN
admet-661	296	13	as	as	ADV
admet-661	296	14	well	well	ADV
admet-661	296	15	as	as	ADP
admet-661	296	16	the	the	DET
admet-661	296	17	equilibrium	equilibrium	NOUN
admet-661	296	18	solid	solid	ADJ
admet-661	296	19	phases	phase	NOUN
admet-661	296	20	may	may	AUX
admet-661	296	21	differ	differ	VERB
admet-661	296	22	depending	depend	VERB
admet-661	296	23	on	on	ADP
admet-661	296	24	how	how	SCONJ
admet-661	296	25	long	long	ADV
admet-661	296	26	the	the	DET
admet-661	296	27	systems	system	NOUN
admet-661	296	28	are	be	AUX
admet-661	296	29	equilibrated	equilibrate	VERB
admet-661	296	30	.	.	PUNCT
admet-661	297	1	therefore	therefore	ADV
admet-661	297	2	,	,	PUNCT
admet-661	297	3	care	care	NOUN
admet-661	297	4	must	must	AUX
admet-661	297	5	be	be	AUX
admet-661	297	6	taken	take	VERB
admet-661	297	7	in	in	ADP
admet-661	297	8	interpreting	interpret	VERB
admet-661	297	9	any	any	DET
admet-661	297	10	solubility	solubility	NOUN
admet-661	297	11	differences	difference	NOUN
admet-661	297	12	between	between	ADP
admet-661	297	13	free	free	ADJ
admet-661	297	14	bases	basis	NOUN
admet-661	297	15	and	and	CCONJ
admet-661	297	16	their	their	PRON
admet-661	297	17	cocrystal	cocrystal	ADJ
admet-661	297	18	forms	form	NOUN
admet-661	297	19	by	by	ADP
admet-661	297	20	taking	take	VERB
admet-661	297	21	the	the	DET
admet-661	297	22	equilibration	equilibration	NOUN
admet-661	297	23	time	time	NOUN
admet-661	297	24	into	into	ADP
admet-661	297	25	consideration	consideration	NOUN
admet-661	297	26	.	.	PUNCT
admet-661	298	1	intrinsic	intrinsic	ADJ
admet-661	298	2	dissolution	dissolution	NOUN
admet-661	298	3	of	of	ADP
admet-661	298	4	ketoconazole	ketoconazole	PROPN
admet-661	298	5	free	free	ADJ
admet-661	298	6	base	base	NOUN
admet-661	298	7	and	and	CCONJ
admet-661	298	8	cocrystals	cocrystal	NOUN
admet-661	298	9	at	at	ADP
admet-661	298	10	different	different	ADJ
admet-661	298	11	ph	ph	ADJ
admet-661	298	12	fig	fig	NOUN
admet-661	298	13	.	.	PUNCT
admet-661	299	1	9	9	NUM
admet-661	299	2	gives	give	VERB
admet-661	299	3	the	the	DET
admet-661	299	4	dissolution	dissolution	NOUN
admet-661	299	5	profiles	profile	NOUN
admet-661	299	6	of	of	ADP
admet-661	299	7	ketoconazole	ketoconazole	NOUN
admet-661	299	8	and	and	CCONJ
admet-661	299	9	its	its	PRON
admet-661	299	10	cocrystals	cocrystal	NOUN
admet-661	299	11	with	with	ADP
admet-661	299	12	fumaric	fumaric	ADJ
admet-661	299	13	acid	acid	PROPN
admet-661	299	14	and	and	CCONJ
admet-661	299	15	succinic	succinic	ADJ
admet-661	299	16	acid	acid	NOUN
admet-661	299	17	at	at	ADP
admet-661	299	18	ph	ph	PROPN
admet-661	299	19	3	3	NUM
admet-661	299	20	,	,	PUNCT
admet-661	299	21	4	4	NUM
admet-661	299	22	and	and	CCONJ
admet-661	299	23	5	5	NUM
admet-661	299	24	from	from	ADP
admet-661	299	25	a	a	DET
admet-661	299	26	constant	constant	ADJ
admet-661	299	27	surface	surface	NOUN
admet-661	299	28	area	area	NOUN
admet-661	299	29	of	of	ADP
admet-661	299	30	0.5	0.5	NUM
admet-661	299	31	cm2	cm2	NOUN
admet-661	299	32	.	.	PUNCT
admet-661	300	1	these	these	DET
admet-661	300	2	ph	ph	ADJ
admet-661	300	3	conditions	condition	NOUN
admet-661	300	4	were	be	AUX
admet-661	300	5	selected	select	VERB
admet-661	300	6	because	because	SCONJ
admet-661	300	7	ph	ph	ADJ
admet-661	300	8	3	3	NUM
admet-661	300	9	was	be	AUX
admet-661	300	10	below	below	ADP
admet-661	300	11	the	the	DET
admet-661	300	12	phmax	phmax	NOUN
admet-661	300	13	,	,	PUNCT
admet-661	300	14	ph	ph	PROPN
admet-661	300	15	4	4	NUM
admet-661	300	16	was	be	AUX
admet-661	300	17	at	at	ADP
admet-661	300	18	around	around	ADP
admet-661	300	19	the	the	DET
admet-661	300	20	phmax	phmax	NOUN
admet-661	300	21	and	and	CCONJ
admet-661	300	22	ph	ph	ADJ
admet-661	300	23	5	5	NUM
admet-661	300	24	was	be	AUX
admet-661	300	25	above	above	ADP
admet-661	300	26	the	the	DET
admet-661	300	27	phmax	phmax	NOUN
admet-661	300	28	.	.	PUNCT
admet-661	301	1	additionally	additionally	ADV
admet-661	301	2	,	,	PUNCT
admet-661	301	3	ph	ph	ADJ
admet-661	301	4	-	-	PUNCT
admet-661	301	5	solubility	solubility	NOUN
admet-661	301	6	profiles	profile	NOUN
admet-661	301	7	in	in	ADP
admet-661	301	8	figs	fig	NOUN
admet-661	301	9	.	.	PUNCT
admet-661	302	1	5	5	NUM
admet-661	302	2	,	,	PUNCT
admet-661	302	3	6	6	NUM
admet-661	302	4	and	and	CCONJ
admet-661	302	5	7	7	NUM
admet-661	302	6	showed	show	VERB
admet-661	302	7	a	a	DET
admet-661	302	8	very	very	ADV
admet-661	302	9	large	large	ADJ
admet-661	302	10	decrease	decrease	NOUN
admet-661	302	11	in	in	ADP
admet-661	302	12	solubility	solubility	NOUN
admet-661	302	13	of	of	ADP
admet-661	302	14	ketoconazole	ketoconazole	NOUN
admet-661	302	15	at	at	ADP
admet-661	302	16	ph	ph	PROPN
admet-661	302	17	5	5	NUM
admet-661	302	18	as	as	SCONJ
admet-661	302	19	compared	compare	VERB
admet-661	302	20	to	to	ADP
admet-661	302	21	those	those	PRON
admet-661	302	22	at	at	ADP
admet-661	302	23	ph	ph	PROPN
admet-661	302	24	3	3	NUM
admet-661	302	25	and	and	CCONJ
admet-661	302	26	4	4	NUM
admet-661	302	27	,	,	PUNCT
admet-661	302	28	and	and	CCONJ
admet-661	302	29	it	it	PRON
admet-661	302	30	was	be	AUX
admet-661	302	31	,	,	PUNCT
admet-661	302	32	therefore	therefore	ADV
admet-661	302	33	,	,	PUNCT
admet-661	302	34	of	of	ADP
admet-661	302	35	interest	interest	NOUN
admet-661	302	36	to	to	PART
admet-661	302	37	study	study	VERB
admet-661	302	38	whether	whether	SCONJ
admet-661	302	39	the	the	DET
admet-661	302	40	difference	difference	NOUN
admet-661	302	41	is	be	AUX
admet-661	302	42	also	also	ADV
admet-661	302	43	reflected	reflect	VERB
admet-661	302	44	in	in	ADP
admet-661	302	45	the	the	DET
admet-661	302	46	dissolution	dissolution	NOUN
admet-661	302	47	rate	rate	NOUN
admet-661	302	48	.	.	PUNCT
admet-661	303	1	there	there	PRON
admet-661	303	2	are	be	VERB
admet-661	303	3	two	two	NUM
admet-661	303	4	sets	set	NOUN
admet-661	303	5	of	of	ADP
admet-661	303	6	dissolution	dissolution	ADJ
admet-661	303	7	profiles	profile	NOUN
admet-661	303	8	in	in	ADP
admet-661	303	9	fig	fig	NOUN
admet-661	303	10	.	.	PUNCT
admet-661	304	1	9	9	NUM
admet-661	304	2	:	:	PUNCT
admet-661	304	3	the	the	DET
admet-661	304	4	first	first	ADJ
admet-661	304	5	was	be	AUX
admet-661	304	6	in	in	ADP
admet-661	304	7	unbuffered	unbuffered	ADJ
admet-661	304	8	media	medium	NOUN
admet-661	304	9	(	(	PUNCT
admet-661	304	10	left	leave	VERB
admet-661	304	11	hand	hand	NOUN
admet-661	304	12	column	column	NOUN
admet-661	304	13	)	)	PUNCT
admet-661	304	14	,	,	PUNCT
admet-661	304	15	where	where	SCONJ
admet-661	304	16	the	the	DET
admet-661	304	17	ph	ph	NOUN
admet-661	304	18	of	of	ADP
admet-661	304	19	dissolution	dissolution	NOUN
admet-661	304	20	media	medium	NOUN
admet-661	304	21	was	be	AUX
admet-661	304	22	kept	keep	VERB
admet-661	304	23	constant	constant	ADJ
admet-661	304	24	by	by	ADP
admet-661	304	25	adding	add	VERB
admet-661	304	26	naoh	naoh	NOUN
admet-661	304	27	or	or	CCONJ
admet-661	304	28	hcl	hcl	PROPN
admet-661	304	29	,	,	PUNCT
admet-661	304	30	as	as	ADP
admet-661	304	31	necessary	necessary	ADJ
admet-661	304	32	,	,	PUNCT
admet-661	304	33	and	and	CCONJ
admet-661	304	34	the	the	DET
admet-661	304	35	second	second	ADJ
admet-661	304	36	was	be	AUX
admet-661	304	37	in	in	ADP
admet-661	304	38	buffered	buffer	VERB
admet-661	304	39	media	medium	NOUN
admet-661	304	40	(	(	PUNCT
admet-661	304	41	right	right	ADJ
admet-661	304	42	hand	hand	NOUN
admet-661	304	43	column	column	NOUN
admet-661	304	44	)	)	PUNCT
admet-661	304	45	,	,	PUNCT
admet-661	304	46	where	where	SCONJ
admet-661	304	47	no	no	DET
admet-661	304	48	ph	ph	ADJ
admet-661	304	49	adjustment	adjustment	NOUN
admet-661	304	50	was	be	AUX
admet-661	304	51	necessary	necessary	ADJ
admet-661	304	52	since	since	SCONJ
admet-661	304	53	the	the	DET
admet-661	304	54	ph	ph	NOUN
admet-661	304	55	did	do	AUX
admet-661	304	56	not	not	PART
admet-661	304	57	change	change	VERB
admet-661	304	58	due	due	ADP
admet-661	304	59	to	to	ADP
admet-661	304	60	the	the	DET
admet-661	304	61	dissolution	dissolution	NOUN
admet-661	304	62	of	of	ADP
admet-661	304	63	drug	drug	NOUN
admet-661	304	64	.	.	PUNCT
admet-661	305	1	the	the	DET
admet-661	305	2	dissolution	dissolution	NOUN
admet-661	305	3	profiles	profile	NOUN
admet-661	305	4	at	at	ADP
admet-661	305	5	ph	ph	PROPN
admet-661	305	6	3	3	NUM
admet-661	305	7	,	,	PUNCT
admet-661	305	8	4	4	NUM
admet-661	305	9	and	and	CCONJ
admet-661	305	10	5	5	NUM
admet-661	305	11	under	under	ADP
admet-661	305	12	ph	ph	ADJ
admet-661	305	13	-	-	PUNCT
admet-661	305	14	stat	stat	NOUN
admet-661	305	15	conditions	condition	NOUN
admet-661	305	16	in	in	ADP
admet-661	305	17	unbuffered	unbuffered	ADJ
admet-661	305	18	media	medium	NOUN
admet-661	305	19	in	in	ADP
admet-661	305	20	fig	fig	NOUN
admet-661	305	21	.	.	PUNCT
admet-661	306	1	9	9	NUM
admet-661	306	2	demonstrate	demonstrate	VERB
admet-661	306	3	that	that	SCONJ
admet-661	306	4	there	there	PRON
admet-661	306	5	was	be	VERB
admet-661	306	6	a	a	DET
admet-661	306	7	great	great	ADJ
admet-661	306	8	impact	impact	NOUN
admet-661	306	9	of	of	ADP
admet-661	306	10	cocrystal	cocrystal	ADJ
admet-661	306	11	formation	formation	NOUN
admet-661	306	12	on	on	ADP
admet-661	306	13	the	the	DET
admet-661	306	14	dissolution	dissolution	NOUN
admet-661	306	15	rate	rate	NOUN
admet-661	306	16	of	of	ADP
admet-661	306	17	ketoconazole	ketoconazole	NOUN
admet-661	306	18	.	.	PUNCT
admet-661	307	1	at	at	ADP
admet-661	307	2	all	all	DET
admet-661	307	3	three	three	NUM
admet-661	307	4	ph	ph	ADJ
admet-661	307	5	conditions	condition	NOUN
admet-661	307	6	,	,	PUNCT
admet-661	307	7	dissolutions	dissolution	NOUN
admet-661	307	8	rates	rate	NOUN
admet-661	307	9	of	of	ADP
admet-661	307	10	cocrystals	cocrystal	NOUN
admet-661	307	11	were	be	AUX
admet-661	307	12	much	much	ADV
admet-661	307	13	higher	high	ADJ
admet-661	307	14	than	than	ADP
admet-661	307	15	those	those	PRON
admet-661	307	16	of	of	ADP
admet-661	307	17	the	the	DET
admet-661	307	18	free	free	ADJ
admet-661	307	19	base	base	NOUN
admet-661	307	20	.	.	PUNCT
admet-661	308	1	previously	previously	ADV
admet-661	308	2	,	,	PUNCT
admet-661	308	3	comparative	comparative	ADJ
admet-661	308	4	dissolution	dissolution	NOUN
admet-661	308	5	studies	study	NOUN
admet-661	308	6	of	of	ADP
admet-661	308	7	free	free	ADJ
admet-661	308	8	base	base	NOUN
admet-661	308	9	and	and	CCONJ
admet-661	308	10	salt	salt	NOUN
admet-661	308	11	forms	form	NOUN
admet-661	308	12	of	of	ADP
admet-661	308	13	drugs	drug	NOUN
admet-661	308	14	were	be	AUX
admet-661	308	15	extensively	extensively	ADV
admet-661	308	16	reported	report	VERB
admet-661	308	17	in	in	ADP
admet-661	308	18	the	the	DET
admet-661	308	19	literature	literature	NOUN
admet-661	308	20	[	[	X
admet-661	308	21	30	30	NUM
admet-661	308	22	-	-	SYM
admet-661	308	23	33	33	NUM
admet-661	308	24	]	]	PUNCT
admet-661	308	25	,	,	PUNCT
admet-661	308	26	where	where	SCONJ
admet-661	308	27	the	the	DET
admet-661	308	28	higher	high	ADJ
admet-661	308	29	dissolution	dissolution	NOUN
admet-661	308	30	rates	rate	NOUN
admet-661	308	31	of	of	ADP
admet-661	308	32	salts	salt	NOUN
admet-661	308	33	than	than	ADP
admet-661	308	34	that	that	PRON
admet-661	308	35	of	of	ADP
admet-661	308	36	their	their	PRON
admet-661	308	37	respective	respective	ADJ
admet-661	308	38	free	free	ADJ
admet-661	308	39	base	base	NOUN
admet-661	308	40	forms	form	NOUN
admet-661	308	41	were	be	AUX
admet-661	308	42	attributed	attribute	VERB
admet-661	308	43	to	to	ADP
admet-661	308	44	the	the	DET
admet-661	308	45	difference	difference	NOUN
admet-661	308	46	in	in	ADP
admet-661	308	47	microenvironmental	microenvironmental	ADJ
admet-661	308	48	ph	ph	ADJ
admet-661	308	49	conditions	condition	NOUN
admet-661	308	50	.	.	PUNCT
admet-661	309	1	essentially	essentially	ADV
admet-661	309	2	,	,	PUNCT
admet-661	309	3	the	the	DET
admet-661	309	4	microenvironmental	microenvironmental	ADJ
admet-661	309	5	ph	ph	NOUN
admet-661	309	6	represents	represent	VERB
admet-661	309	7	the	the	DET
admet-661	309	8	ph	ph	NOUN
admet-661	309	9	at	at	ADP
admet-661	309	10	the	the	DET
admet-661	309	11	surface	surface	NOUN
admet-661	309	12	of	of	ADP
admet-661	309	13	solid	solid	ADJ
admet-661	309	14	when	when	SCONJ
admet-661	309	15	the	the	DET
admet-661	309	16	diffusion	diffusion	NOUN
admet-661	309	17	layer	layer	NOUN
admet-661	309	18	thickness	thickness	NOUN
admet-661	309	19	,	,	PUNCT
admet-661	309	20	h	h	NOUN
admet-661	309	21	,	,	PUNCT
admet-661	309	22	approaches	approach	NOUN
admet-661	309	23	zero	zero	NUM
admet-661	309	24	,	,	PUNCT
admet-661	309	25	i.e.	i.e.	X
admet-661	309	26	,	,	PUNCT
admet-661	309	27	h=0	h=0	PROPN
admet-661	309	28	,	,	PUNCT
admet-661	309	29	and	and	CCONJ
admet-661	309	30	the	the	DET
admet-661	309	31	solubility	solubility	NOUN
admet-661	309	32	of	of	ADP
admet-661	309	33	drug	drug	NOUN
admet-661	309	34	at	at	ADP
admet-661	309	35	such	such	DET
admet-661	309	36	a	a	DET
admet-661	309	37	ph	ph	NOUN
admet-661	309	38	,	,	PUNCT
admet-661	309	39	and	and	CCONJ
admet-661	309	40	not	not	PART
admet-661	309	41	at	at	ADP
admet-661	309	42	the	the	DET
admet-661	309	43	bulk	bulk	ADJ
admet-661	309	44	ph	ph	NOUN
admet-661	309	45	of	of	ADP
admet-661	309	46	the	the	DET
admet-661	309	47	dissolution	dissolution	PROPN
admet-661	309	48	medium	medium	NOUN
admet-661	309	49	,	,	PUNCT
admet-661	309	50	dictates	dictate	VERB
admet-661	309	51	the	the	DET
admet-661	309	52	dissolution	dissolution	ADJ
admet-661	309	53	rate	rate	NOUN
admet-661	309	54	of	of	ADP
admet-661	309	55	drug	drug	NOUN
admet-661	309	56	.	.	PUNCT
admet-661	310	1	the	the	DET
admet-661	310	2	microenvironmental	microenvironmental	ADJ
admet-661	310	3	ph	ph	NOUN
admet-661	310	4	at	at	ADP
admet-661	310	5	the	the	DET
admet-661	310	6	surface	surface	NOUN
admet-661	310	7	of	of	ADP
admet-661	310	8	dissolving	dissolve	VERB
admet-661	310	9	solid	solid	ADJ
admet-661	310	10	is	be	AUX
admet-661	310	11	often	often	ADV
admet-661	310	12	represented	represent	VERB
admet-661	310	13	as	as	ADP
admet-661	310	14	phh=0	phh=0	ADJ
admet-661	310	15	.	.	PUNCT
admet-661	311	1	the	the	DET
admet-661	311	2	difference	difference	NOUN
admet-661	311	3	in	in	ADP
admet-661	311	4	dissolution	dissolution	ADJ
admet-661	311	5	rates	rate	NOUN
admet-661	311	6	of	of	ADP
admet-661	311	7	ketoconazole	ketoconazole	NOUN
admet-661	311	8	and	and	CCONJ
admet-661	311	9	its	its	PRON
admet-661	311	10	cocrystals	cocrystal	NOUN
admet-661	311	11	may	may	AUX
admet-661	311	12	also	also	ADV
admet-661	311	13	be	be	AUX
admet-661	311	14	explained	explain	VERB
admet-661	311	15	by	by	ADP
admet-661	311	16	possible	possible	ADJ
admet-661	311	17	differences	difference	NOUN
admet-661	311	18	in	in	ADP
admet-661	311	19	their	their	PRON
admet-661	311	20	phh=0	phh=0	NOUN
admet-661	311	21	.	.	PUNCT
admet-661	312	1	to	to	PART
admet-661	312	2	confirm	confirm	VERB
admet-661	312	3	the	the	DET
admet-661	312	4	relationship	relationship	NOUN
admet-661	312	5	between	between	ADP
admet-661	312	6	microenvironmental	microenvironmental	ADJ
admet-661	312	7	ph	ph	ADJ
admet-661	312	8	and	and	CCONJ
admet-661	312	9	superior	superior	ADJ
admet-661	312	10	dissolution	dissolution	NOUN
admet-661	312	11	rates	rate	NOUN
admet-661	312	12	of	of	ADP
admet-661	312	13	cocrystals	cocrystal	NOUN
admet-661	312	14	as	as	ADP
admet-661	312	15	compared	compare	VERB
admet-661	312	16	to	to	ADP
admet-661	312	17	the	the	DET
admet-661	312	18	free	free	ADJ
admet-661	312	19	base	base	NOUN
admet-661	312	20	,	,	PUNCT
admet-661	312	21	dissolution	dissolution	ADJ
admet-661	312	22	studies	study	NOUN
admet-661	312	23	of	of	ADP
admet-661	312	24	cocrystals	cocrystal	NOUN
admet-661	312	25	and	and	CCONJ
admet-661	312	26	the	the	DET
admet-661	312	27	free	free	ADJ
admet-661	312	28	base	base	NOUN
admet-661	312	29	at	at	ADP
admet-661	312	30	ph	ph	PROPN
admet-661	312	31	3	3	NUM
admet-661	312	32	,	,	PUNCT
admet-661	312	33	4	4	NUM
admet-661	312	34	and	and	CCONJ
admet-661	312	35	5	5	NUM
admet-661	312	36	were	be	AUX
admet-661	312	37	also	also	ADV
admet-661	312	38	conducted	conduct	VERB
admet-661	312	39	in	in	ADP
admet-661	312	40	buffered	buffered	ADJ
admet-661	312	41	media	medium	NOUN
admet-661	312	42	,	,	PUNCT
admet-661	312	43	and	and	CCONJ
admet-661	312	44	the	the	DET
admet-661	312	45	results	result	NOUN
admet-661	312	46	are	be	AUX
admet-661	312	47	given	give	VERB
admet-661	312	48	in	in	ADP
admet-661	312	49	fig	fig	NOUN
admet-661	312	50	.	.	PUNCT
admet-661	313	1	9	9	NUM
admet-661	313	2	in	in	ADP
admet-661	313	3	the	the	DET
admet-661	313	4	right	right	ADJ
admet-661	313	5	hand	hand	NOUN
admet-661	313	6	side	side	NOUN
admet-661	313	7	along	along	ADP
admet-661	313	8	with	with	ADP
admet-661	313	9	those	those	PRON
admet-661	313	10	in	in	ADP
admet-661	313	11	the	the	DET
admet-661	313	12	left	left	ADJ
admet-661	313	13	hand	hand	NOUN
admet-661	313	14	side	side	NOUN
admet-661	313	15	for	for	ADP
admet-661	313	16	unbuffered	unbuffered	ADJ
admet-661	313	17	media	medium	NOUN
admet-661	313	18	.	.	PUNCT
admet-661	314	1	table	table	NOUN
admet-661	314	2	3	3	NUM
admet-661	314	3	gives	give	VERB
admet-661	314	4	their	their	PRON
admet-661	314	5	phh=0	phh=0	ADJ
admet-661	314	6	values	value	NOUN
admet-661	314	7	under	under	ADP
admet-661	314	8	buffered	buffer	VERB
admet-661	314	9	bulk	bulk	ADJ
admet-661	314	10	ph	ph	NOUN
admet-661	314	11	conditions	condition	NOUN
admet-661	314	12	of	of	ADP
admet-661	314	13	3	3	NUM
admet-661	314	14	,	,	PUNCT
admet-661	314	15	4	4	NUM
admet-661	314	16	and	and	CCONJ
admet-661	314	17	5	5	NUM
admet-661	314	18	as	as	SCONJ
admet-661	314	19	determined	determine	VERB
admet-661	314	20	by	by	ADP
admet-661	314	21	the	the	DET
admet-661	314	22	slurry	slurry	NOUN
admet-661	314	23	ph	ph	NOUN
admet-661	314	24	method	method	NOUN
admet-661	314	25	described	describe	VERB
admet-661	314	26	earlier	early	ADV
admet-661	314	27	in	in	ADP
admet-661	314	28	the	the	DET
admet-661	314	29	literature	literature	NOUN
admet-661	314	30	[	[	X
admet-661	314	31	30	30	NUM
admet-661	314	32	,	,	PUNCT
admet-661	314	33	40	40	NUM
admet-661	314	34	]	]	PUNCT
admet-661	314	35	.	.	PUNCT
admet-661	315	1	essentially	essentially	ADV
admet-661	315	2	,	,	PUNCT
admet-661	315	3	in	in	ADP
admet-661	315	4	the	the	DET
admet-661	315	5	present	present	ADJ
admet-661	315	6	investigation	investigation	NOUN
admet-661	315	7	,	,	PUNCT
admet-661	315	8	about	about	ADV
admet-661	315	9	0.5	0.5	NUM
admet-661	315	10	ml	ml	NOUN
admet-661	315	11	of	of	ADP
admet-661	315	12	buffer	buffer	NOUN
admet-661	315	13	was	be	AUX
admet-661	315	14	added	add	VERB
admet-661	315	15	to	to	ADP
admet-661	315	16	200	200	NUM
admet-661	315	17	mg	mg	NOUN
admet-661	315	18	of	of	ADP
admet-661	315	19	powder	powder	NOUN
admet-661	315	20	in	in	ADP
admet-661	315	21	a	a	DET
admet-661	315	22	small	small	ADJ
admet-661	315	23	vial	vial	ADJ
admet-661	315	24	and	and	CCONJ
admet-661	315	25	mixed	mix	VERB
admet-661	315	26	by	by	ADP
admet-661	315	27	vortexing	vortexing	NOUN
admet-661	315	28	,	,	PUNCT
admet-661	315	29	and	and	CCONJ
admet-661	315	30	then	then	ADV
admet-661	315	31	ph	ph	PROPN
admet-661	315	32	was	be	AUX
admet-661	315	33	recorded	record	VERB
admet-661	315	34	when	when	SCONJ
admet-661	315	35	an	an	DET
admet-661	315	36	equilibrium	equilibrium	NOUN
admet-661	315	37	was	be	AUX
admet-661	315	38	reached	reach	VERB
admet-661	315	39	after	after	ADP
admet-661	315	40	5	5	NUM
admet-661	315	41	-	-	SYM
admet-661	315	42	10	10	NUM
admet-661	315	43	min	min	NOUN
admet-661	315	44	of	of	ADP
admet-661	315	45	mixing	mix	VERB
admet-661	315	46	.	.	PUNCT
admet-661	316	1	although	although	SCONJ
admet-661	316	2	no	no	DET
admet-661	316	3	dissolution	dissolution	NOUN
admet-661	316	4	testing	testing	NOUN
admet-661	316	5	was	be	AUX
admet-661	316	6	done	do	VERB
admet-661	316	7	at	at	ADP
admet-661	316	8	ph	ph	PROPN
admet-661	316	9	7	7	NUM
admet-661	316	10	,	,	PUNCT
admet-661	316	11	phh=0	phh=0	ADJ
admet-661	316	12	values	value	NOUN
admet-661	316	13	at	at	ADP
admet-661	316	14	this	this	DET
admet-661	316	15	bulk	bulk	ADJ
admet-661	316	16	ph	ph	NOUN
admet-661	316	17	condition	condition	NOUN
admet-661	316	18	are	be	AUX
admet-661	316	19	also	also	ADV
admet-661	316	20	given	give	VERB
admet-661	316	21	in	in	ADP
admet-661	316	22	table	table	NOUN
admet-661	316	23	2	2	NUM
admet-661	316	24	for	for	ADP
admet-661	316	25	a	a	DET
admet-661	316	26	comparison	comparison	NOUN
admet-661	316	27	with	with	ADP
admet-661	316	28	those	those	PRON
admet-661	316	29	at	at	ADP
admet-661	316	30	ph	ph	NOUN
admet-661	316	31	5	5	NUM
admet-661	316	32	.	.	PUNCT
admet-661	317	1	it	it	PRON
admet-661	317	2	may	may	AUX
admet-661	317	3	be	be	AUX
admet-661	317	4	observed	observe	VERB
admet-661	317	5	that	that	SCONJ
admet-661	317	6	phh=0	phh=0	ADJ
admet-661	317	7	values	value	NOUN
admet-661	317	8	of	of	ADP
admet-661	317	9	ketoconazole	ketoconazole	PROPN
admet-661	317	10	cocrystals	cocrystal	NOUN
admet-661	317	11	during	during	ADP
admet-661	317	12	dissolution	dissolution	NOUN
admet-661	317	13	in	in	ADP
admet-661	317	14	ph	ph	PROPN
admet-661	317	15	3	3	NUM
admet-661	317	16	,	,	PUNCT
admet-661	317	17	4	4	NUM
admet-661	317	18	and	and	CCONJ
admet-661	317	19	5	5	NUM
admet-661	317	20	buffers	buffer	NOUN
admet-661	317	21	were	be	AUX
admet-661	317	22	in	in	ADP
admet-661	317	23	the	the	DET
admet-661	317	24	range	range	NOUN
admet-661	317	25	of	of	ADP
admet-661	317	26	3.13	3.13	NUM
admet-661	317	27	and	and	CCONJ
admet-661	317	28	4.38	4.38	NUM
admet-661	317	29	.	.	PUNCT
admet-661	318	1	the	the	DET
admet-661	318	2	dissolution	dissolution	ADJ
admet-661	318	3	profiles	profile	NOUN
admet-661	318	4	in	in	ADP
admet-661	318	5	fig	fig	NOUN
admet-661	318	6	.	.	PUNCT
admet-661	319	1	9	9	NUM
admet-661	319	2	are	be	AUX
admet-661	319	3	in	in	ADP
admet-661	319	4	general	general	ADJ
admet-661	319	5	agreement	agreement	NOUN
admet-661	319	6	with	with	ADP
admet-661	319	7	the	the	DET
admet-661	319	8	ketoconazole	ketoconazole	PROPN
admet-661	319	9	solubility	solubility	NOUN
admet-661	319	10	in	in	ADP
admet-661	319	11	this	this	DET
admet-661	319	12	microenvironmental	microenvironmental	ADJ
admet-661	319	13	ph	ph	ADJ
admet-661	319	14	range	range	NOUN
admet-661	319	15	,	,	PUNCT
admet-661	319	16	as	as	SCONJ
admet-661	319	17	shown	show	VERB
admet-661	319	18	in	in	ADP
admet-661	319	19	fig	fig	NOUN
admet-661	319	20	.	.	PUNCT
admet-661	320	1	5	5	NUM
admet-661	320	2	.	.	X
admet-661	320	3	for	for	ADP
admet-661	320	4	example	example	NOUN
admet-661	320	5	,	,	PUNCT
admet-661	320	6	it	it	PRON
admet-661	320	7	may	may	AUX
admet-661	320	8	be	be	AUX
admet-661	320	9	noted	note	VERB
admet-661	320	10	in	in	ADP
admet-661	320	11	table	table	NOUN
admet-661	320	12	3	3	NUM
admet-661	320	13	that	that	PRON
admet-661	320	14	phh=0	phh=0	ADJ
admet-661	320	15	values	value	NOUN
admet-661	320	16	of	of	ADP
admet-661	320	17	the	the	DET
admet-661	320	18	free	free	ADJ
admet-661	320	19	base	base	NOUN
admet-661	320	20	and	and	CCONJ
admet-661	320	21	the	the	DET
admet-661	320	22	two	two	NUM
admet-661	320	23	cocrystals	cocrystal	NOUN
admet-661	320	24	in	in	ADP
admet-661	320	25	the	the	DET
admet-661	320	26	ph	ph	ADJ
admet-661	320	27	4	4	NUM
admet-661	320	28	buffer	buffer	NOUN
admet-661	320	29	ranged	range	VERB
admet-661	320	30	from	from	ADP
admet-661	320	31	4.08	4.08	NUM
admet-661	320	32	to	to	ADP
admet-661	320	33	4.38	4.38	NUM
admet-661	320	34	,	,	PUNCT
admet-661	320	35	and	and	CCONJ
admet-661	320	36	due	due	ADP
admet-661	320	37	to	to	ADP
admet-661	320	38	the	the	DET
admet-661	320	39	similarity	similarity	NOUN
admet-661	320	40	in	in	ADP
admet-661	320	41	solubility	solubility	NOUN
admet-661	320	42	in	in	ADP
admet-661	320	43	this	this	DET
admet-661	320	44	ph	ph	ADJ
admet-661	320	45	range	range	NOUN
admet-661	320	46	,	,	PUNCT
admet-661	320	47	their	their	PRON
admet-661	320	48	dissolution	dissolution	ADJ
admet-661	320	49	profiles	profile	NOUN
admet-661	320	50	in	in	ADP
admet-661	320	51	fig	fig	NOUN
admet-661	320	52	.	.	PUNCT
admet-661	321	1	9	9	NUM
admet-661	321	2	were	be	AUX
admet-661	321	3	also	also	ADV
admet-661	321	4	similar	similar	ADJ
admet-661	321	5	.	.	PUNCT
admet-661	322	1	when	when	SCONJ
admet-661	322	2	the	the	DET
admet-661	322	3	free	free	ADJ
admet-661	322	4	base	base	NOUN
admet-661	322	5	by	by	ADP
admet-661	322	6	itself	itself	PRON
admet-661	322	7	is	be	AUX
admet-661	322	8	considered	consider	VERB
admet-661	322	9	,	,	PUNCT
admet-661	322	10	its	its	PRON
admet-661	322	11	phh=0	phh=0	ADJ
admet-661	322	12	values	value	NOUN
admet-661	322	13	at	at	ADP
admet-661	322	14	ph	ph	PROPN
admet-661	322	15	3	3	NUM
admet-661	322	16	and	and	CCONJ
admet-661	322	17	4	4	NUM
admet-661	322	18	buffers	buffer	NOUN
admet-661	322	19	were	be	AUX
admet-661	322	20	,	,	PUNCT
admet-661	322	21	respectively	respectively	ADV
admet-661	322	22	,	,	PUNCT
admet-661	322	23	4.17	4.17	NUM
admet-661	322	24	and	and	CCONJ
admet-661	322	25	4.38	4.38	NUM
admet-661	322	26	(	(	PUNCT
admet-661	322	27	table	table	NOUN
admet-661	322	28	3	3	NUM
admet-661	322	29	)	)	PUNCT
admet-661	322	30	and	and	CCONJ
admet-661	322	31	,	,	PUNCT
admet-661	322	32	therefore	therefore	ADV
admet-661	322	33	,	,	PUNCT
admet-661	322	34	its	its	PRON
admet-661	322	35	dissolution	dissolution	NOUN
admet-661	322	36	rates	rate	NOUN
admet-661	322	37	under	under	ADP
admet-661	322	38	ph	ph	PROPN
admet-661	322	39	3	3	NUM
admet-661	322	40	and	and	CCONJ
admet-661	322	41	4	4	NUM
admet-661	322	42	bulk	bulk	ADJ
admet-661	322	43	ph	ph	NOUN
admet-661	322	44	conditions	condition	NOUN
admet-661	322	45	were	be	AUX
admet-661	322	46	also	also	ADV
admet-661	322	47	relatively	relatively	ADV
admet-661	322	48	high	high	ADJ
admet-661	322	49	as	as	SCONJ
admet-661	322	50	compared	compare	VERB
admet-661	322	51	to	to	ADP
admet-661	322	52	that	that	PRON
admet-661	322	53	in	in	ADP
admet-661	322	54	the	the	DET
admet-661	322	55	ph	ph	ADJ
admet-661	322	56	5	5	NUM
admet-661	322	57	buffer	buffer	NOUN
admet-661	322	58	(	(	PUNCT
admet-661	322	59	fig	fig	NOUN
admet-661	322	60	.	.	PUNCT
admet-661	323	1	9	9	NUM
admet-661	323	2	)	)	PUNCT
admet-661	323	3	,	,	PUNCT
admet-661	323	4	where	where	SCONJ
admet-661	323	5	the	the	DET
admet-661	323	6	microenvironmental	microenvironmental	ADJ
admet-661	323	7	ph	ph	NOUN
admet-661	323	8	did	do	AUX
admet-661	323	9	not	not	PART
admet-661	323	10	change	change	VERB
admet-661	323	11	significantly	significantly	ADV
admet-661	323	12	and	and	CCONJ
admet-661	323	13	the	the	DET
admet-661	323	14	solubility	solubility	NOUN
admet-661	323	15	would	would	AUX
admet-661	323	16	be	be	AUX
admet-661	323	17	low	low	ADJ
admet-661	323	18	.	.	PUNCT
admet-661	324	1	admet	admet	PROPN
admet-661	324	2	&	&	CCONJ
admet-661	324	3	dmpk	dmpk	PROPN
admet-661	324	4	7(2	7(2	NUM
admet-661	324	5	)	)	PUNCT
admet-661	324	6	(	(	PUNCT
admet-661	324	7	2019	2019	NUM
admet-661	324	8	)	)	PUNCT
admet-661	324	9	106	106	NUM
admet-661	324	10	-	-	SYM
admet-661	324	11	130	130	NUM
admet-661	324	12	solubility	solubility	NOUN
admet-661	324	13	and	and	CCONJ
admet-661	324	14	dissolution	dissolution	NOUN
admet-661	324	15	of	of	ADP
admet-661	324	16	cocrystals	cocrystal	NOUN
admet-661	324	17	doi	doi	NOUN
admet-661	324	18	:	:	PUNCT
admet-661	324	19	10.5599	10.5599	NUM
admet-661	324	20	/	/	SYM
admet-661	324	21	admet.661	admet.661	PROPN
admet-661	324	22	123	123	NUM
admet-661	324	23	it	it	PRON
admet-661	324	24	may	may	AUX
admet-661	324	25	be	be	AUX
admet-661	324	26	noticed	notice	VERB
admet-661	324	27	in	in	ADP
admet-661	324	28	table	table	NOUN
admet-661	324	29	3	3	NUM
admet-661	324	30	that	that	PRON
admet-661	324	31	throughout	throughout	ADP
admet-661	324	32	the	the	DET
admet-661	324	33	wide	wide	ADJ
admet-661	324	34	bulk	bulk	ADJ
admet-661	324	35	ph	ph	NOUN
admet-661	324	36	range	range	NOUN
admet-661	324	37	of	of	ADP
admet-661	324	38	3	3	NUM
admet-661	324	39	to	to	PART
admet-661	324	40	7	7	NUM
admet-661	324	41	,	,	PUNCT
admet-661	324	42	phh=0	phh=0	ADJ
admet-661	324	43	of	of	ADP
admet-661	324	44	the	the	DET
admet-661	324	45	succinic	succinic	ADJ
admet-661	324	46	acid	acid	NOUN
admet-661	324	47	cocrystal	cocrystal	NOUN
admet-661	324	48	remained	remain	VERB
admet-661	324	49	within	within	ADP
admet-661	324	50	a	a	DET
admet-661	324	51	narrow	narrow	ADJ
admet-661	324	52	range	range	NOUN
admet-661	324	53	of	of	ADP
admet-661	324	54	4.2	4.2	NUM
admet-661	324	55	to	to	PART
admet-661	324	56	4.7	4.7	NUM
admet-661	324	57	.	.	PUNCT
admet-661	325	1	it	it	PRON
admet-661	325	2	is	be	AUX
admet-661	325	3	apparent	apparent	ADJ
admet-661	325	4	that	that	SCONJ
admet-661	325	5	this	this	PRON
admet-661	325	6	is	be	AUX
admet-661	325	7	due	due	ADJ
admet-661	325	8	to	to	ADP
admet-661	325	9	the	the	DET
admet-661	325	10	buffering	buffering	NOUN
admet-661	325	11	action	action	NOUN
admet-661	325	12	of	of	ADP
admet-661	325	13	succinic	succinic	ADJ
admet-661	325	14	acid	acid	NOUN
admet-661	325	15	present	present	NOUN
admet-661	325	16	in	in	ADP
admet-661	325	17	the	the	DET
admet-661	325	18	cocrystal	cocrystal	NOUN
admet-661	325	19	,	,	PUNCT
admet-661	325	20	since	since	SCONJ
admet-661	325	21	succinic	succinic	ADJ
admet-661	325	22	acid	acid	NOUN
admet-661	325	23	has	have	VERB
admet-661	325	24	two	two	NUM
admet-661	325	25	pka	pka	PROPN
admet-661	325	26	values	value	NOUN
admet-661	325	27	of	of	ADP
admet-661	325	28	4.2	4.2	NUM
admet-661	325	29	and	and	CCONJ
admet-661	325	30	5.6	5.6	NUM
admet-661	325	31	and	and	CCONJ
admet-661	325	32	a	a	DET
admet-661	325	33	buffer	buffer	NOUN
admet-661	325	34	would	would	AUX
admet-661	325	35	be	be	AUX
admet-661	325	36	formed	form	VERB
admet-661	325	37	around	around	ADP
admet-661	325	38	the	the	DET
admet-661	325	39	lower	low	ADJ
admet-661	325	40	pka	pka	PROPN
admet-661	325	41	value	value	NOUN
admet-661	325	42	.	.	PUNCT
admet-661	326	1	the	the	DET
admet-661	326	2	fumaric	fumaric	ADJ
admet-661	326	3	acid	acid	PROPN
admet-661	326	4	cocrystals	cocrystal	NOUN
admet-661	326	5	exhibited	exhibit	VERB
admet-661	326	6	somewhat	somewhat	ADV
admet-661	326	7	lower	low	ADJ
admet-661	326	8	phh=0	phh=0	ADJ
admet-661	326	9	value	value	NOUN
admet-661	326	10	since	since	SCONJ
admet-661	326	11	it	it	PRON
admet-661	326	12	would	would	AUX
admet-661	326	13	possibly	possibly	ADV
admet-661	326	14	buffer	buffer	VERB
admet-661	326	15	to	to	ADP
admet-661	326	16	a	a	DET
admet-661	326	17	lower	low	ADJ
admet-661	326	18	ph	ph	NOUN
admet-661	326	19	due	due	ADP
admet-661	326	20	to	to	PART
admet-661	326	21	lower	lower	VERB
admet-661	326	22	pka	pka	PROPN
admet-661	326	23	values	value	NOUN
admet-661	326	24	(	(	PUNCT
admet-661	326	25	3.0	3.0	NUM
admet-661	326	26	and	and	CCONJ
admet-661	326	27	4.4	4.4	NUM
admet-661	326	28	)	)	PUNCT
admet-661	326	29	.	.	PUNCT
admet-661	327	1	thus	thus	ADV
admet-661	327	2	,	,	PUNCT
admet-661	327	3	the	the	DET
admet-661	327	4	acidity	acidity	NOUN
admet-661	327	5	of	of	ADP
admet-661	327	6	coformers	coformer	NOUN
admet-661	327	7	can	can	AUX
admet-661	327	8	have	have	VERB
admet-661	327	9	certain	certain	ADJ
admet-661	327	10	effects	effect	NOUN
admet-661	327	11	on	on	ADP
admet-661	327	12	the	the	DET
admet-661	327	13	dissolution	dissolution	NOUN
admet-661	327	14	of	of	ADP
admet-661	327	15	formed	form	VERB
admet-661	327	16	cocrystals	cocrystal	NOUN
admet-661	327	17	as	as	SCONJ
admet-661	327	18	different	different	ADJ
admet-661	327	19	coformers	coformer	NOUN
admet-661	327	20	can	can	AUX
admet-661	327	21	modulate	modulate	VERB
admet-661	327	22	microenvironmental	microenvironmental	ADJ
admet-661	327	23	ph	ph	NOUN
admet-661	327	24	differently	differently	ADV
admet-661	327	25	.	.	PUNCT
admet-661	328	1	figure	figure	VERB
admet-661	328	2	9	9	NUM
admet-661	328	3	.	.	PUNCT
admet-661	328	4	intrinsic	intrinsic	ADJ
admet-661	328	5	dissolution	dissolution	ADJ
admet-661	328	6	profiles	profile	NOUN
admet-661	328	7	of	of	ADP
admet-661	328	8	ketoconazole	ketoconazole	PROPN
admet-661	328	9	base	base	NOUN
admet-661	328	10	(	(	PUNCT
admet-661	328	11	ktz	ktz	PROPN
admet-661	328	12	)	)	PUNCT
admet-661	328	13	and	and	CCONJ
admet-661	328	14	its	its	PRON
admet-661	328	15	cocrystals	cocrystal	NOUN
admet-661	328	16	ketoconazole	ketoconazole	NOUN
admet-661	328	17	-	-	PUNCT
admet-661	328	18	fumaric	fumaric	NOUN
admet-661	328	19	acid	acid	NOUN
admet-661	328	20	(	(	PUNCT
admet-661	328	21	ktz	ktz	NOUN
admet-661	328	22	fum	fum	NOUN
admet-661	328	23	)	)	PUNCT
admet-661	328	24	and	and	CCONJ
admet-661	328	25	ketoconazole	ketoconazole	NOUN
admet-661	328	26	-	-	PUNCT
admet-661	328	27	succinic	succinic	ADJ
admet-661	328	28	acid	acid	NOUN
admet-661	328	29	(	(	PUNCT
admet-661	328	30	ktz	ktz	PROPN
admet-661	328	31	suc	suc	PROPN
admet-661	328	32	)	)	PUNCT
admet-661	328	33	from	from	ADP
admet-661	328	34	a	a	DET
admet-661	328	35	constant	constant	ADJ
admet-661	328	36	surface	surface	NOUN
admet-661	328	37	area	area	NOUN
admet-661	328	38	of	of	ADP
admet-661	328	39	0.5	0.5	NUM
admet-661	328	40	cm	cm	NOUN
admet-661	328	41	2	2	NUM
admet-661	328	42	in	in	ADP
admet-661	328	43	unbuffered	unbuffered	ADJ
admet-661	328	44	media	medium	NOUN
admet-661	328	45	where	where	SCONJ
admet-661	328	46	ph	ph	PROPN
admet-661	328	47	was	be	AUX
admet-661	328	48	kept	keep	VERB
admet-661	328	49	constant	constant	ADJ
admet-661	328	50	by	by	ADP
admet-661	328	51	adding	add	VERB
admet-661	328	52	hcl	hcl	PROPN
admet-661	328	53	or	or	CCONJ
admet-661	328	54	naoh	naoh	NOUN
admet-661	328	55	,	,	PUNCT
admet-661	328	56	as	as	ADV
admet-661	328	57	necessary	necessary	ADJ
admet-661	328	58	(	(	PUNCT
admet-661	328	59	left	left	ADJ
admet-661	328	60	hand	hand	NOUN
admet-661	328	61	column	column	NOUN
admet-661	328	62	)	)	PUNCT
admet-661	328	63	and	and	CCONJ
admet-661	328	64	in	in	ADP
admet-661	328	65	buffers	buffer	NOUN
admet-661	328	66	(	(	PUNCT
admet-661	328	67	right	right	ADJ
admet-661	328	68	hand	hand	NOUN
admet-661	328	69	column	column	NOUN
admet-661	328	70	)	)	PUNCT
admet-661	328	71	.	.	PUNCT
admet-661	329	1	vasoya	vasoya	PROPN
admet-661	329	2	et	et	PROPN
admet-661	329	3	al	al	PROPN
admet-661	329	4	.	.	PROPN
admet-661	329	5	admet	admet	PROPN
admet-661	329	6	&	&	CCONJ
admet-661	329	7	dmpk	dmpk	PROPN
admet-661	329	8	7(2	7(2	NUM
admet-661	329	9	)	)	PUNCT
admet-661	329	10	(	(	PUNCT
admet-661	329	11	2019	2019	NUM
admet-661	329	12	)	)	PUNCT
admet-661	329	13	106	106	NUM
admet-661	329	14	-	-	SYM
admet-661	329	15	130	130	NUM
admet-661	329	16	124	124	NUM
admet-661	329	17	in	in	ADP
admet-661	329	18	addition	addition	NOUN
admet-661	329	19	to	to	ADP
admet-661	329	20	the	the	DET
admet-661	329	21	modulation	modulation	NOUN
admet-661	329	22	of	of	ADP
admet-661	329	23	microenvironmental	microenvironmental	ADJ
admet-661	329	24	ph	ph	PROPN
admet-661	329	25	,	,	PUNCT
admet-661	329	26	the	the	DET
admet-661	329	27	dissolution	dissolution	NOUN
admet-661	329	28	rates	rate	NOUN
admet-661	329	29	of	of	ADP
admet-661	329	30	cocrystals	cocrystal	NOUN
admet-661	329	31	and	and	CCONJ
admet-661	329	32	free	free	ADJ
admet-661	329	33	base	base	NOUN
admet-661	329	34	may	may	AUX
admet-661	329	35	also	also	ADV
admet-661	329	36	be	be	AUX
admet-661	329	37	influenced	influence	VERB
admet-661	329	38	by	by	ADP
admet-661	329	39	the	the	DET
admet-661	329	40	supersaturation	supersaturation	NOUN
admet-661	329	41	of	of	ADP
admet-661	329	42	drugs	drug	NOUN
admet-661	329	43	in	in	ADP
admet-661	329	44	the	the	DET
admet-661	329	45	diffusion	diffusion	NOUN
admet-661	329	46	layer	layer	NOUN
admet-661	329	47	.	.	PUNCT
admet-661	330	1	such	such	ADJ
admet-661	330	2	supersaturation	supersaturation	NOUN
admet-661	330	3	was	be	AUX
admet-661	330	4	observed	observe	VERB
admet-661	330	5	earlier	early	ADV
admet-661	330	6	during	during	ADP
admet-661	330	7	the	the	DET
admet-661	330	8	dissolution	dissolution	NOUN
admet-661	330	9	of	of	ADP
admet-661	330	10	salts	salt	NOUN
admet-661	330	11	[	[	X
admet-661	330	12	33	33	NUM
admet-661	330	13	]	]	PUNCT
admet-661	330	14	and	and	CCONJ
admet-661	330	15	free	free	ADJ
admet-661	330	16	bases	basis	NOUN
admet-661	330	17	[	[	X
admet-661	330	18	30	30	NUM
admet-661	330	19	]	]	PUNCT
admet-661	330	20	,	,	PUNCT
admet-661	330	21	which	which	PRON
admet-661	330	22	greatly	greatly	ADV
admet-661	330	23	influenced	influence	VERB
admet-661	330	24	their	their	PRON
admet-661	330	25	dissolution	dissolution	NOUN
admet-661	330	26	rates	rate	NOUN
admet-661	330	27	.	.	PUNCT
admet-661	331	1	it	it	PRON
admet-661	331	2	is	be	AUX
admet-661	331	3	possible	possible	ADJ
admet-661	331	4	that	that	SCONJ
admet-661	331	5	a	a	DET
admet-661	331	6	similar	similar	ADJ
admet-661	331	7	supersaturation	supersaturation	NOUN
admet-661	331	8	occurred	occur	VERB
admet-661	331	9	in	in	ADP
admet-661	331	10	diffusion	diffusion	NOUN
admet-661	331	11	layers	layer	NOUN
admet-661	331	12	during	during	ADP
admet-661	331	13	the	the	DET
admet-661	331	14	dissolution	dissolution	NOUN
admet-661	331	15	of	of	ADP
admet-661	331	16	ketoconazole	ketoconazole	PROPN
admet-661	331	17	cocrystals	cocrystal	NOUN
admet-661	331	18	at	at	ADP
admet-661	331	19	relatively	relatively	ADV
admet-661	331	20	high	high	ADJ
admet-661	331	21	ph	ph	NOUN
admet-661	331	22	(	(	PUNCT
admet-661	331	23	e.g.	e.g.	ADV
admet-661	331	24	,	,	PUNCT
admet-661	331	25	ph	ph	NOUN
admet-661	331	26	5	5	NUM
admet-661	331	27	)	)	PUNCT
admet-661	331	28	due	due	ADP
admet-661	331	29	to	to	ADP
admet-661	331	30	the	the	DET
admet-661	331	31	acid	acid	NOUN
admet-661	331	32	-	-	PUNCT
admet-661	331	33	base	base	NOUN
admet-661	331	34	interaction	interaction	NOUN
admet-661	331	35	;	;	PUNCT
admet-661	331	36	the	the	DET
admet-661	331	37	dissolution	dissolution	NOUN
admet-661	331	38	of	of	ADP
admet-661	331	39	free	free	ADJ
admet-661	331	40	base	base	NOUN
admet-661	331	41	at	at	ADP
admet-661	331	42	relatively	relatively	ADV
admet-661	331	43	lower	low	ADJ
admet-661	331	44	ph	ph	NOUN
admet-661	331	45	(	(	PUNCT
admet-661	331	46	e.g.	e.g.	ADV
admet-661	331	47	,	,	PUNCT
admet-661	331	48	ph	ph	NOUN
admet-661	331	49	3	3	NUM
admet-661	331	50	and	and	CCONJ
admet-661	331	51	4	4	NUM
admet-661	331	52	)	)	PUNCT
admet-661	331	53	would	would	AUX
admet-661	331	54	also	also	ADV
admet-661	331	55	be	be	AUX
admet-661	331	56	influenced	influence	VERB
admet-661	331	57	by	by	ADP
admet-661	331	58	such	such	DET
admet-661	331	59	an	an	DET
admet-661	331	60	interaction	interaction	NOUN
admet-661	331	61	.	.	PUNCT
admet-661	332	1	therefore	therefore	ADV
admet-661	332	2	,	,	PUNCT
admet-661	332	3	a	a	DET
admet-661	332	4	combination	combination	NOUN
admet-661	332	5	of	of	ADP
admet-661	332	6	the	the	DET
admet-661	332	7	lowering	lowering	NOUN
admet-661	332	8	of	of	ADP
admet-661	332	9	surface	surface	NOUN
admet-661	332	10	ph	ph	NOUN
admet-661	332	11	(	(	PUNCT
admet-661	332	12	phh=0	phh=0	ADJ
admet-661	332	13	)	)	PUNCT
admet-661	332	14	and	and	CCONJ
admet-661	332	15	the	the	DET
admet-661	332	16	supersaturation	supersaturation	NOUN
admet-661	332	17	of	of	ADP
admet-661	332	18	drug	drug	NOUN
admet-661	332	19	in	in	ADP
admet-661	332	20	the	the	DET
admet-661	332	21	diffusion	diffusion	NOUN
admet-661	332	22	layer	layer	NOUN
admet-661	332	23	could	could	AUX
admet-661	332	24	be	be	AUX
admet-661	332	25	responsible	responsible	ADJ
admet-661	332	26	for	for	ADP
admet-661	332	27	high	high	ADJ
admet-661	332	28	dissolution	dissolution	NOUN
admet-661	332	29	rates	rate	NOUN
admet-661	332	30	of	of	ADP
admet-661	332	31	cocrystals	cocrystal	NOUN
admet-661	332	32	observed	observe	VERB
admet-661	332	33	in	in	ADP
admet-661	332	34	ph	ph	PROPN
admet-661	332	35	5	5	NUM
admet-661	332	36	buffered	buffer	VERB
admet-661	332	37	and	and	CCONJ
admet-661	332	38	unbuffered	unbuffered	ADJ
admet-661	332	39	media	medium	NOUN
admet-661	332	40	.	.	PUNCT
admet-661	333	1	in	in	ADP
admet-661	333	2	addition	addition	NOUN
admet-661	333	3	to	to	ADP
admet-661	333	4	phh=0	phh=0	VERB
admet-661	333	5	values	value	NOUN
admet-661	333	6	for	for	ADP
admet-661	333	7	ph	ph	ADJ
admet-661	333	8	3	3	NUM
admet-661	333	9	,	,	PUNCT
admet-661	333	10	4	4	NUM
admet-661	333	11	and	and	CCONJ
admet-661	333	12	5	5	NUM
admet-661	333	13	buffers	buffer	NOUN
admet-661	333	14	,	,	PUNCT
admet-661	333	15	such	such	ADJ
admet-661	333	16	values	value	NOUN
admet-661	333	17	for	for	ADP
admet-661	333	18	the	the	DET
admet-661	333	19	ph	ph	ADJ
admet-661	333	20	7	7	NUM
admet-661	333	21	buffer	buffer	NOUN
admet-661	333	22	are	be	AUX
admet-661	333	23	also	also	ADV
admet-661	333	24	given	give	VERB
admet-661	333	25	in	in	ADP
admet-661	333	26	table	table	NOUN
admet-661	333	27	3	3	NUM
admet-661	333	28	.	.	PUNCT
admet-661	334	1	since	since	SCONJ
admet-661	334	2	phh=0	phh=0	ADJ
admet-661	334	3	values	value	NOUN
admet-661	334	4	for	for	ADP
admet-661	334	5	fumaric	fumaric	ADJ
admet-661	334	6	acid	acid	PROPN
admet-661	334	7	and	and	CCONJ
admet-661	334	8	succinic	succinic	ADJ
admet-661	334	9	acid	acid	NOUN
admet-661	334	10	cocrystals	cocrystal	NOUN
admet-661	334	11	at	at	ADP
admet-661	334	12	this	this	DET
admet-661	334	13	ph	ph	NOUN
admet-661	334	14	were	be	AUX
admet-661	334	15	,	,	PUNCT
admet-661	334	16	respectively	respectively	ADV
admet-661	334	17	,	,	PUNCT
admet-661	334	18	4.53	4.53	NUM
admet-661	334	19	and	and	CCONJ
admet-661	334	20	4.67	4.67	NUM
admet-661	334	21	,	,	PUNCT
admet-661	334	22	where	where	SCONJ
admet-661	334	23	the	the	DET
admet-661	334	24	drug	drug	NOUN
admet-661	334	25	solubility	solubility	NOUN
admet-661	334	26	is	be	AUX
admet-661	334	27	expected	expect	VERB
admet-661	334	28	to	to	PART
admet-661	334	29	be	be	AUX
admet-661	334	30	much	much	ADV
admet-661	334	31	higher	high	ADJ
admet-661	334	32	than	than	ADP
admet-661	334	33	that	that	PRON
admet-661	334	34	at	at	ADP
admet-661	334	35	the	the	DET
admet-661	334	36	phh=0	phh=0	NOUN
admet-661	334	37	of	of	ADP
admet-661	334	38	free	free	ADJ
admet-661	334	39	base	base	NOUN
admet-661	334	40	(	(	PUNCT
admet-661	334	41	ph	ph	NOUN
admet-661	334	42	7.05	7.05	NUM
admet-661	334	43	)	)	PUNCT
admet-661	334	44	,	,	PUNCT
admet-661	334	45	it	it	PRON
admet-661	334	46	is	be	AUX
admet-661	334	47	expected	expect	VERB
admet-661	334	48	that	that	SCONJ
admet-661	334	49	dissolution	dissolution	ADJ
admet-661	334	50	rates	rate	NOUN
admet-661	334	51	of	of	ADP
admet-661	334	52	cocrystals	cocrystal	NOUN
admet-661	334	53	at	at	ADP
admet-661	334	54	ph	ph	PROPN
admet-661	334	55	7	7	NUM
admet-661	334	56	would	would	AUX
admet-661	334	57	also	also	ADV
admet-661	334	58	be	be	AUX
admet-661	334	59	much	much	ADV
admet-661	334	60	higher	high	ADJ
admet-661	334	61	than	than	ADP
admet-661	334	62	that	that	PRON
admet-661	334	63	of	of	ADP
admet-661	334	64	the	the	DET
admet-661	334	65	free	free	ADJ
admet-661	334	66	base	base	NOUN
admet-661	334	67	.	.	PUNCT
admet-661	335	1	table	table	NOUN
admet-661	335	2	3	3	NUM
admet-661	335	3	.	.	PUNCT
admet-661	336	1	microenvironmental	microenvironmental	ADJ
admet-661	336	2	ph	ph	NOUN
admet-661	336	3	(	(	PUNCT
admet-661	336	4	phh=0	phh=0	ADJ
admet-661	336	5	)	)	PUNCT
admet-661	336	6	at	at	ADP
admet-661	336	7	the	the	DET
admet-661	336	8	surface	surface	NOUN
admet-661	336	9	of	of	ADP
admet-661	336	10	ketoconazole	ketoconazole	PROPN
admet-661	336	11	(	(	PUNCT
admet-661	336	12	ktz	ktz	NOUN
admet-661	336	13	)	)	PUNCT
admet-661	336	14	free	free	ADJ
admet-661	336	15	base	base	NOUN
admet-661	336	16	,	,	PUNCT
admet-661	336	17	ketoconazole	ketoconazole	NOUN
admet-661	336	18	-	-	PUNCT
admet-661	336	19	fumaric	fumaric	NOUN
admet-661	336	20	acid	acid	NOUN
admet-661	336	21	(	(	PUNCT
admet-661	336	22	ktz	ktz	NOUN
admet-661	336	23	-	-	PUNCT
admet-661	336	24	fum	fum	NOUN
admet-661	336	25	)	)	PUNCT
admet-661	336	26	cocrystal	cocrystal	ADJ
admet-661	336	27	and	and	CCONJ
admet-661	336	28	ketoconazole	ketoconazole	NOUN
admet-661	336	29	-	-	PUNCT
admet-661	336	30	succinic	succinic	ADJ
admet-661	336	31	acid	acid	NOUN
admet-661	336	32	(	(	PUNCT
admet-661	336	33	ktz	ktz	NOUN
admet-661	336	34	-	-	PUNCT
admet-661	336	35	suc	suc	ADJ
admet-661	336	36	)	)	PUNCT
admet-661	336	37	cocrystal	cocrystal	VERB
admet-661	336	38	during	during	ADP
admet-661	336	39	dissolution	dissolution	ADJ
admet-661	336	40	testing	testing	NOUN
admet-661	336	41	in	in	ADP
admet-661	336	42	different	different	ADJ
admet-661	336	43	buffers	buffer	NOUN
admet-661	336	44	as	as	SCONJ
admet-661	336	45	determined	determine	VERB
admet-661	336	46	by	by	ADP
admet-661	336	47	the	the	DET
admet-661	336	48	slurry	slurry	NOUN
admet-661	336	49	ph	ph	NOUN
admet-661	336	50	method	method	NOUN
admet-661	336	51	.	.	PUNCT
admet-661	337	1	each	each	DET
admet-661	337	2	ph	ph	NOUN
admet-661	337	3	value	value	NOUN
admet-661	337	4	is	be	AUX
admet-661	337	5	the	the	DET
admet-661	337	6	average	average	NOUN
admet-661	337	7	of	of	ADP
admet-661	337	8	two	two	NUM
admet-661	337	9	determinations	determination	NOUN
admet-661	337	10	buffers	buffer	NOUN
admet-661	337	11	ph	ph	X
admet-661	337	12	h=0	h=0	PROPN
admet-661	337	13	(	(	PUNCT
admet-661	337	14	slurry	slurry	NOUN
admet-661	337	15	ph	ph	NOUN
admet-661	337	16	)	)	PUNCT
admet-661	337	17	composition	composition	NOUN
admet-661	337	18	initial	initial	ADJ
admet-661	337	19	ph	ph	NOUN
admet-661	337	20	(	(	PUNCT
admet-661	337	21	bulk	bulk	NOUN
admet-661	337	22	ph	ph	NOUN
admet-661	337	23	)	)	PUNCT
admet-661	337	24	ktz	ktz	NOUN
admet-661	337	25	base	base	NOUN
admet-661	337	26	ktz	ktz	NOUN
admet-661	337	27	-	-	PUNCT
admet-661	337	28	fum	fum	NOUN
admet-661	337	29	cocrystal	cocrystal	ADJ
admet-661	337	30	ktz	ktz	PROPN
admet-661	337	31	-	-	PUNCT
admet-661	337	32	suc	suc	ADJ
admet-661	337	33	cocrystal	cocrystal	ADJ
admet-661	337	34	ph	ph	ADJ
admet-661	337	35	3	3	NUM
admet-661	337	36	phthalate	phthalate	NOUN
admet-661	337	37	buffer	buffer	NOUN
admet-661	337	38	2.93	2.93	NUM
admet-661	337	39	4.17	4.17	NUM
admet-661	337	40	3.13	3.13	NUM
admet-661	337	41	4.38	4.38	NUM
admet-661	337	42	ph	ph	NOUN
admet-661	337	43	4	4	NUM
admet-661	337	44	phthalate	phthalate	NOUN
admet-661	337	45	buffer	buffer	NOUN
admet-661	337	46	3.96	3.96	NUM
admet-661	337	47	4.38	4.38	NUM
admet-661	337	48	4.08	4.08	NUM
admet-661	337	49	4.19	4.19	NUM
admet-661	337	50	ph	ph	NOUN
admet-661	337	51	5	5	NUM
admet-661	337	52	neutralized	neutralize	VERB
admet-661	337	53	phthalate	phthalate	NOUN
admet-661	337	54	buffer	buffer	NOUN
admet-661	337	55	4.97	4.97	NUM
admet-661	337	56	5.00	5.00	NUM
admet-661	337	57	4.23	4.23	NUM
admet-661	337	58	4.40	4.40	NUM
admet-661	337	59	ph	ph	ADJ
admet-661	337	60	7	7	NUM
admet-661	337	61	phosphate	phosphate	NOUN
admet-661	337	62	buffer	buffer	NOUN
admet-661	337	63	6.97	6.97	NUM
admet-661	337	64	7.05	7.05	NUM
admet-661	337	65	4.53	4.53	NUM
admet-661	337	66	4.67	4.67	NUM
admet-661	337	67	surface	surface	NOUN
admet-661	337	68	ph	ph	NOUN
admet-661	337	69	or	or	CCONJ
admet-661	337	70	phh=0	phh=0	ADJ
admet-661	337	71	during	during	ADP
admet-661	337	72	the	the	DET
admet-661	337	73	dissolution	dissolution	NOUN
admet-661	337	74	of	of	ADP
admet-661	337	75	cocrystals	cocrystal	NOUN
admet-661	337	76	and	and	CCONJ
admet-661	337	77	free	free	ADJ
admet-661	337	78	base	base	NOUN
admet-661	337	79	in	in	ADP
admet-661	337	80	unbuffered	unbuffered	ADJ
admet-661	337	81	media	medium	NOUN
admet-661	337	82	could	could	AUX
admet-661	337	83	not	not	PART
admet-661	337	84	be	be	AUX
admet-661	337	85	accurately	accurately	ADV
admet-661	337	86	predicted	predict	VERB
admet-661	337	87	by	by	ADP
admet-661	337	88	the	the	DET
admet-661	337	89	slurry	slurry	NOUN
admet-661	337	90	ph	ph	NOUN
admet-661	337	91	method	method	NOUN
admet-661	337	92	.	.	PUNCT
admet-661	338	1	unlike	unlike	ADP
admet-661	338	2	dissolution	dissolution	NOUN
admet-661	338	3	testing	testing	NOUN
admet-661	338	4	,	,	PUNCT
admet-661	338	5	where	where	SCONJ
admet-661	338	6	hcl	hcl	PROPN
admet-661	338	7	or	or	CCONJ
admet-661	338	8	naoh	naoh	NOUN
admet-661	338	9	were	be	AUX
admet-661	338	10	continuously	continuously	ADV
admet-661	338	11	added	add	VERB
admet-661	338	12	to	to	PART
admet-661	338	13	keep	keep	VERB
admet-661	338	14	the	the	DET
admet-661	338	15	ph	ph	NOUN
admet-661	338	16	of	of	ADP
admet-661	338	17	bulk	bulk	ADJ
admet-661	338	18	media	medium	NOUN
admet-661	338	19	constant	constant	ADJ
admet-661	338	20	,	,	PUNCT
admet-661	338	21	no	no	DET
admet-661	338	22	such	such	ADJ
admet-661	338	23	addition	addition	NOUN
admet-661	338	24	of	of	ADP
admet-661	338	25	acid	acid	NOUN
admet-661	338	26	or	or	CCONJ
admet-661	338	27	alkali	alkali	ADJ
admet-661	338	28	was	be	AUX
admet-661	338	29	possible	possible	ADJ
admet-661	338	30	during	during	ADP
admet-661	338	31	the	the	DET
admet-661	338	32	determination	determination	NOUN
admet-661	338	33	of	of	ADP
admet-661	338	34	slurry	slurry	NOUN
admet-661	338	35	ph	ph	VERB
admet-661	338	36	.	.	PUNCT
admet-661	339	1	since	since	SCONJ
admet-661	339	2	the	the	DET
admet-661	339	3	media	medium	NOUN
admet-661	339	4	did	do	AUX
admet-661	339	5	not	not	PART
admet-661	339	6	have	have	VERB
admet-661	339	7	any	any	DET
admet-661	339	8	buffer	buffer	NOUN
admet-661	339	9	capacity	capacity	NOUN
admet-661	339	10	,	,	PUNCT
admet-661	339	11	the	the	DET
admet-661	339	12	ph	ph	NOUN
admet-661	339	13	in	in	ADP
admet-661	339	14	presence	presence	NOUN
admet-661	339	15	of	of	ADP
admet-661	339	16	excess	excess	ADJ
admet-661	339	17	solids	solid	NOUN
admet-661	339	18	in	in	ADP
admet-661	339	19	these	these	DET
admet-661	339	20	media	medium	NOUN
admet-661	339	21	were	be	AUX
admet-661	339	22	essentially	essentially	ADV
admet-661	339	23	similar	similar	ADJ
admet-661	339	24	to	to	ADP
admet-661	339	25	those	those	PRON
admet-661	339	26	in	in	ADP
admet-661	339	27	water	water	NOUN
admet-661	339	28	.	.	PUNCT
admet-661	340	1	however	however	ADV
admet-661	340	2	,	,	PUNCT
admet-661	340	3	the	the	DET
admet-661	340	4	dissolution	dissolution	NOUN
admet-661	340	5	profiles	profile	NOUN
admet-661	340	6	in	in	ADP
admet-661	340	7	unbuffered	unbuffered	ADJ
admet-661	340	8	media	medium	NOUN
admet-661	340	9	in	in	ADP
admet-661	340	10	fig	fig	NOUN
admet-661	340	11	.	.	PUNCT
admet-661	341	1	9	9	NUM
admet-661	341	2	indicated	indicate	VERB
admet-661	341	3	that	that	SCONJ
admet-661	341	4	they	they	PRON
admet-661	341	5	were	be	AUX
admet-661	341	6	also	also	ADV
admet-661	341	7	influenced	influence	VERB
admet-661	341	8	by	by	ADP
admet-661	341	9	the	the	DET
admet-661	341	10	microenvironmental	microenvironmental	ADJ
admet-661	341	11	ph	ph	NOUN
admet-661	341	12	at	at	ADP
admet-661	341	13	the	the	DET
admet-661	341	14	surface	surface	NOUN
admet-661	341	15	of	of	ADP
admet-661	341	16	dissolving	dissolve	VERB
admet-661	341	17	solids	solid	NOUN
admet-661	341	18	.	.	PUNCT
admet-661	342	1	table	table	NOUN
admet-661	342	2	4	4	NUM
admet-661	342	3	.	.	PUNCT
admet-661	342	4	intrinsic	intrinsic	ADJ
admet-661	342	5	dissolution	dissolution	NOUN
admet-661	342	6	rates	rate	NOUN
admet-661	342	7	of	of	ADP
admet-661	342	8	ketoconazole	ketoconazole	PROPN
admet-661	342	9	(	(	PUNCT
admet-661	342	10	ktz	ktz	NOUN
admet-661	342	11	)	)	PUNCT
admet-661	342	12	free	free	ADJ
admet-661	342	13	base	base	NOUN
admet-661	342	14	and	and	CCONJ
admet-661	342	15	its	its	PRON
admet-661	342	16	cocrystals	cocrystal	NOUN
admet-661	342	17	with	with	ADP
admet-661	342	18	fumaric	fumaric	ADJ
admet-661	342	19	acid	acid	PROPN
admet-661	342	20	(	(	PUNCT
admet-661	342	21	ktz	ktz	NOUN
admet-661	342	22	-	-	PUNCT
admet-661	342	23	fum	fum	NOUN
admet-661	342	24	)	)	PUNCT
admet-661	342	25	and	and	CCONJ
admet-661	342	26	succinic	succinic	ADJ
admet-661	342	27	acid	acid	NOUN
admet-661	342	28	(	(	PUNCT
admet-661	342	29	ktz	ktz	NOUN
admet-661	342	30	-	-	PUNCT
admet-661	342	31	suc	suc	ADJ
admet-661	342	32	)	)	PUNCT
admet-661	342	33	in	in	ADP
admet-661	342	34	unbuffered	unbuffered	ADJ
admet-661	342	35	and	and	CCONJ
admet-661	342	36	buffered	buffered	ADJ
admet-661	342	37	media	medium	NOUN
admet-661	342	38	at	at	ADP
admet-661	342	39	different	different	ADJ
admet-661	342	40	ph	ph	PROPN
admet-661	342	41	.	.	PROPN
admet-661	342	42	ph	ph	ADJ
admet-661	342	43	dissolution	dissolution	NOUN
admet-661	342	44	rate	rate	NOUN
admet-661	342	45	constant	constant	ADJ
admet-661	342	46	(	(	PUNCT
admet-661	342	47	µg.min	µg.min	PROPN
admet-661	342	48	-1	-1	INTJ
admet-661	342	49	.cm	.cm	PUNCT
admet-661	342	50	-2	-2	PUNCT
admet-661	342	51	)	)	PUNCT
admet-661	342	52	unbuffered	unbuffered	ADJ
admet-661	342	53	media	medium	NOUN
admet-661	342	54	*	*	PUNCT
admet-661	342	55	buffers	buffer	NOUN
admet-661	342	56	ktz	ktz	NOUN
admet-661	342	57	-	-	PUNCT
admet-661	342	58	fum	fum	NOUN
admet-661	342	59	ktz	ktz	NOUN
admet-661	342	60	-	-	PUNCT
admet-661	342	61	suc	suc	VERB
admet-661	342	62	ktz	ktz	PROPN
admet-661	342	63	base	base	NOUN
admet-661	342	64	ktz	ktz	NOUN
admet-661	342	65	-	-	PUNCT
admet-661	342	66	fum	fum	NOUN
admet-661	342	67	ktz	ktz	NOUN
admet-661	342	68	-	-	PUNCT
admet-661	342	69	suc	suc	VERB
admet-661	342	70	ktz	ktz	PROPN
admet-661	342	71	base	base	NOUN
admet-661	342	72	ph	ph	NOUN
admet-661	342	73	3	3	NUM
admet-661	342	74	164	164	NUM
admet-661	342	75	185	185	NUM
admet-661	342	76	106	106	NUM
admet-661	342	77	108	108	NUM
admet-661	342	78	91	91	NUM
admet-661	342	79	108	108	NUM
admet-661	342	80	ph	ph	NOUN
admet-661	342	81	4	4	NUM
admet-661	342	82	124	124	NUM
admet-661	342	83	105	105	NUM
admet-661	342	84	16	16	NUM
admet-661	342	85	71	71	NUM
admet-661	342	86	65	65	NUM
admet-661	342	87	45	45	NUM
admet-661	342	88	ph	ph	NOUN
admet-661	342	89	5	5	NUM
admet-661	342	90	93	93	NUM
admet-661	342	91	62	62	NUM
admet-661	342	92	-	-	SYM
admet-661	342	93	*	*	PUNCT
admet-661	342	94	*	*	NOUN
admet-661	342	95	51	51	NUM
admet-661	342	96	48	48	NUM
admet-661	342	97	-	-	SYM
admet-661	342	98	*	*	SYM
admet-661	342	99	*	*	PUNCT
admet-661	342	100	*	*	PUNCT
admet-661	342	101	ph	ph	NOUN
admet-661	342	102	of	of	ADP
admet-661	342	103	bulk	bulk	ADJ
admet-661	342	104	media	medium	NOUN
admet-661	342	105	kept	keep	VERB
admet-661	342	106	constant	constant	ADJ
admet-661	342	107	by	by	ADP
admet-661	342	108	adding	add	VERB
admet-661	342	109	hcl	hcl	PROPN
admet-661	342	110	or	or	CCONJ
admet-661	342	111	naoh	naoh	NOUN
admet-661	342	112	solutions	solution	NOUN
admet-661	342	113	,	,	PUNCT
admet-661	342	114	as	as	ADP
admet-661	342	115	necessary	necessary	ADJ
admet-661	342	116	*	*	NOUN
admet-661	342	117	*	*	ADJ
admet-661	342	118	extremely	extremely	ADV
admet-661	342	119	low	low	ADJ
admet-661	342	120	dissolution	dissolution	NOUN
admet-661	342	121	rate	rate	NOUN
admet-661	342	122	(	(	PUNCT
admet-661	342	123	practically	practically	ADV
admet-661	342	124	zero	zero	NUM
admet-661	342	125	)	)	PUNCT
admet-661	342	126	that	that	PRON
admet-661	342	127	could	could	AUX
admet-661	342	128	not	not	PART
admet-661	342	129	be	be	AUX
admet-661	342	130	calculated	calculate	VERB
admet-661	342	131	with	with	ADP
admet-661	342	132	accuracy	accuracy	NOUN
admet-661	342	133	.	.	PUNCT
admet-661	343	1	intrinsic	intrinsic	ADJ
admet-661	343	2	dissolution	dissolution	NOUN
admet-661	343	3	rates	rate	NOUN
admet-661	343	4	of	of	ADP
admet-661	343	5	ketoconazole	ketoconazole	NOUN
admet-661	343	6	-	-	PUNCT
admet-661	343	7	fumaric	fumaric	ADJ
admet-661	343	8	acid	acid	PROPN
admet-661	343	9	cocrystal	cocrystal	PROPN
admet-661	343	10	,	,	PUNCT
admet-661	343	11	ketoconazole	ketoconazole	NOUN
admet-661	343	12	-	-	PUNCT
admet-661	343	13	succinic	succinic	ADJ
admet-661	343	14	acid	acid	NOUN
admet-661	343	15	cocrystal	cocrystal	NOUN
admet-661	343	16	and	and	CCONJ
admet-661	343	17	ketoconazole	ketoconazole	NOUN
admet-661	343	18	free	free	ADJ
admet-661	343	19	base	base	NOUN
admet-661	343	20	at	at	ADP
admet-661	343	21	ph	ph	PROPN
admet-661	343	22	3	3	NUM
admet-661	343	23	,	,	PUNCT
admet-661	343	24	4	4	NUM
admet-661	343	25	and	and	CCONJ
admet-661	343	26	5	5	NUM
admet-661	343	27	,	,	PUNCT
admet-661	343	28	as	as	SCONJ
admet-661	343	29	calculated	calculate	VERB
admet-661	343	30	from	from	ADP
admet-661	343	31	the	the	DET
admet-661	343	32	graphs	graph	NOUN
admet-661	343	33	in	in	ADP
admet-661	343	34	fig	fig	NOUN
admet-661	343	35	.	.	PUNCT
admet-661	344	1	9	9	NUM
admet-661	344	2	,	,	PUNCT
admet-661	344	3	are	be	AUX
admet-661	344	4	given	give	VERB
admet-661	344	5	in	in	ADP
admet-661	344	6	table	table	NOUN
admet-661	344	7	4	4	NUM
admet-661	344	8	,	,	PUNCT
admet-661	344	9	which	which	PRON
admet-661	344	10	essentially	essentially	ADV
admet-661	344	11	confirm	confirm	VERB
admet-661	344	12	high	high	ADJ
admet-661	344	13	dissolution	dissolution	NOUN
admet-661	344	14	rates	rate	NOUN
admet-661	344	15	of	of	ADP
admet-661	344	16	both	both	DET
admet-661	344	17	cocrystals	cocrystal	NOUN
admet-661	344	18	at	at	ADP
admet-661	344	19	ph	ph	PROPN
admet-661	344	20	3	3	NUM
admet-661	344	21	,	,	PUNCT
admet-661	344	22	4	4	NUM
admet-661	344	23	and	and	CCONJ
admet-661	344	24	5	5	NUM
admet-661	344	25	mentioned	mention	VERB
admet-661	344	26	above	above	ADV
admet-661	344	27	.	.	PUNCT
admet-661	345	1	in	in	ADP
admet-661	345	2	contrast	contrast	NOUN
admet-661	345	3	,	,	PUNCT
admet-661	345	4	dissolution	dissolution	ADJ
admet-661	345	5	rates	rate	NOUN
admet-661	345	6	of	of	ADP
admet-661	345	7	the	the	DET
admet-661	345	8	free	free	ADJ
admet-661	345	9	base	base	NOUN
admet-661	345	10	decreased	decrease	VERB
admet-661	345	11	with	with	ADP
admet-661	345	12	the	the	DET
admet-661	345	13	increase	increase	NOUN
admet-661	345	14	in	in	ADP
admet-661	345	15	ph	ph	NOUN
admet-661	345	16	from	from	ADP
admet-661	345	17	3	3	NUM
admet-661	345	18	to	to	ADP
admet-661	345	19	4	4	NUM
admet-661	345	20	,	,	PUNCT
admet-661	345	21	and	and	CCONJ
admet-661	345	22	at	at	ADP
admet-661	345	23	ph	ph	ADJ
admet-661	345	24	5	5	NUM
admet-661	345	25	,	,	PUNCT
admet-661	345	26	the	the	DET
admet-661	345	27	admet	admet	PROPN
admet-661	345	28	&	&	CCONJ
admet-661	345	29	dmpk	dmpk	PROPN
admet-661	345	30	7(2	7(2	NUM
admet-661	345	31	)	)	PUNCT
admet-661	345	32	(	(	PUNCT
admet-661	345	33	2019	2019	NUM
admet-661	345	34	)	)	PUNCT
admet-661	345	35	106	106	NUM
admet-661	345	36	-	-	SYM
admet-661	345	37	130	130	NUM
admet-661	345	38	solubility	solubility	NOUN
admet-661	345	39	and	and	CCONJ
admet-661	345	40	dissolution	dissolution	NOUN
admet-661	345	41	of	of	ADP
admet-661	345	42	cocrystals	cocrystal	NOUN
admet-661	345	43	doi	doi	NOUN
admet-661	345	44	:	:	PUNCT
admet-661	345	45	10.5599	10.5599	NUM
admet-661	345	46	/	/	SYM
admet-661	345	47	admet.661	admet.661	PROPN
admet-661	345	48	125	125	NUM
admet-661	345	49	dissolution	dissolution	NOUN
admet-661	345	50	rate	rate	NOUN
admet-661	345	51	decreased	decrease	VERB
admet-661	345	52	to	to	ADP
admet-661	345	53	practically	practically	ADV
admet-661	345	54	negligible	negligible	ADJ
admet-661	345	55	level	level	NOUN
admet-661	345	56	.	.	PUNCT
admet-661	346	1	although	although	SCONJ
admet-661	346	2	individual	individual	ADJ
admet-661	346	3	values	value	NOUN
admet-661	346	4	for	for	ADP
admet-661	346	5	dissolution	dissolution	ADJ
admet-661	346	6	rate	rate	NOUN
admet-661	346	7	constants	constant	NOUN
admet-661	346	8	at	at	ADP
admet-661	346	9	each	each	DET
admet-661	346	10	ph	ph	NOUN
admet-661	346	11	may	may	AUX
admet-661	346	12	vary	vary	VERB
admet-661	346	13	due	due	ADJ
admet-661	346	14	to	to	ADP
admet-661	346	15	such	such	ADJ
admet-661	346	16	factors	factor	NOUN
admet-661	346	17	as	as	ADP
admet-661	346	18	microenvironmental	microenvironmental	ADJ
admet-661	346	19	ph	ph	NOUN
admet-661	346	20	,	,	PUNCT
admet-661	346	21	supersaturation	supersaturation	NOUN
admet-661	346	22	,	,	PUNCT
admet-661	346	23	etc	etc	X
admet-661	346	24	.	.	X
admet-661	346	25	,	,	PUNCT
admet-661	346	26	mentioned	mention	VERB
admet-661	346	27	earlier	early	ADV
admet-661	346	28	,	,	PUNCT
admet-661	346	29	the	the	DET
admet-661	346	30	results	result	NOUN
admet-661	346	31	demonstrate	demonstrate	VERB
admet-661	346	32	that	that	SCONJ
admet-661	346	33	although	although	SCONJ
admet-661	346	34	there	there	PRON
admet-661	346	35	may	may	AUX
admet-661	346	36	not	not	PART
admet-661	346	37	be	be	AUX
admet-661	346	38	significant	significant	ADJ
admet-661	346	39	difference	difference	NOUN
admet-661	346	40	in	in	ADP
admet-661	346	41	equilibrium	equilibrium	NOUN
admet-661	346	42	solubility	solubility	NOUN
admet-661	346	43	between	between	ADP
admet-661	346	44	ketoconazole	ketoconazole	PROPN
admet-661	346	45	free	free	ADJ
admet-661	346	46	base	base	NOUN
admet-661	346	47	and	and	CCONJ
admet-661	346	48	cocrystals	cocrystal	NOUN
admet-661	346	49	at	at	ADP
admet-661	346	50	any	any	DET
admet-661	346	51	particular	particular	ADJ
admet-661	346	52	ph	ph	NOUN
admet-661	346	53	,	,	PUNCT
admet-661	346	54	the	the	DET
admet-661	346	55	cocrystal	cocrystal	ADJ
admet-661	346	56	formation	formation	NOUN
admet-661	346	57	can	can	AUX
admet-661	346	58	greatly	greatly	ADV
admet-661	346	59	increase	increase	VERB
admet-661	346	60	dissolution	dissolution	ADJ
admet-661	346	61	rates	rate	NOUN
admet-661	346	62	of	of	ADP
admet-661	346	63	basic	basic	ADJ
admet-661	346	64	drugs	drug	NOUN
admet-661	346	65	at	at	ADP
admet-661	346	66	relatively	relatively	ADV
admet-661	346	67	high	high	ADJ
admet-661	346	68	ph	ph	NOUN
admet-661	346	69	conditions	condition	NOUN
admet-661	346	70	by	by	ADP
admet-661	346	71	modulating	modulate	VERB
admet-661	346	72	microenvironmental	microenvironmental	ADJ
admet-661	346	73	ph	ph	NOUN
admet-661	346	74	during	during	ADP
admet-661	346	75	dissolution	dissolution	NOUN
admet-661	346	76	testing	testing	NOUN
admet-661	346	77	.	.	PUNCT
admet-661	347	1	consequently	consequently	ADV
admet-661	347	2	,	,	PUNCT
admet-661	347	3	for	for	ADP
admet-661	347	4	certain	certain	ADJ
admet-661	347	5	basic	basic	ADJ
admet-661	347	6	drugs	drug	NOUN
admet-661	347	7	like	like	ADP
admet-661	347	8	ketoconazole	ketoconazole	NOUN
admet-661	347	9	,	,	PUNCT
admet-661	347	10	dissolution	dissolution	NOUN
admet-661	347	11	rates	rate	NOUN
admet-661	347	12	of	of	ADP
admet-661	347	13	cocrystals	cocrystal	NOUN
admet-661	347	14	could	could	AUX
admet-661	347	15	be	be	AUX
admet-661	347	16	higher	high	ADJ
admet-661	347	17	than	than	ADP
admet-661	347	18	their	their	PRON
admet-661	347	19	respective	respective	ADJ
admet-661	347	20	free	free	ADJ
admet-661	347	21	base	base	NOUN
admet-661	347	22	forms	form	NOUN
admet-661	347	23	.	.	PUNCT
admet-661	348	1	the	the	DET
admet-661	348	2	mechanism	mechanism	NOUN
admet-661	348	3	why	why	SCONJ
admet-661	348	4	dissolution	dissolution	ADJ
admet-661	348	5	rates	rate	NOUN
admet-661	348	6	of	of	ADP
admet-661	348	7	cocrystals	cocrystal	NOUN
admet-661	348	8	at	at	ADP
admet-661	348	9	ph	ph	PROPN
admet-661	348	10	3	3	NUM
admet-661	348	11	,	,	PUNCT
admet-661	348	12	4	4	NUM
admet-661	348	13	and	and	CCONJ
admet-661	348	14	5	5	NUM
admet-661	348	15	in	in	ADP
admet-661	348	16	table	table	NOUN
admet-661	348	17	4	4	NUM
admet-661	348	18	in	in	ADP
admet-661	348	19	unbuffered	unbuffered	ADJ
admet-661	348	20	media	medium	NOUN
admet-661	348	21	were	be	AUX
admet-661	348	22	higher	high	ADJ
admet-661	348	23	than	than	ADP
admet-661	348	24	those	those	PRON
admet-661	348	25	in	in	ADP
admet-661	348	26	buffered	buffered	ADJ
admet-661	348	27	media	medium	NOUN
admet-661	348	28	has	have	AUX
admet-661	348	29	not	not	PART
admet-661	348	30	been	be	AUX
admet-661	348	31	investigated	investigate	VERB
admet-661	348	32	.	.	PUNCT
admet-661	349	1	summary	summary	NOUN
admet-661	349	2	and	and	CCONJ
admet-661	349	3	conclusions	conclusion	NOUN
admet-661	349	4	to	to	PART
admet-661	349	5	address	address	VERB
admet-661	349	6	different	different	ADJ
admet-661	349	7	issues	issue	NOUN
admet-661	349	8	with	with	ADP
admet-661	349	9	respect	respect	NOUN
admet-661	349	10	to	to	ADP
admet-661	349	11	solubility	solubility	NOUN
admet-661	349	12	and	and	CCONJ
admet-661	349	13	dissolution	dissolution	NOUN
admet-661	349	14	rate	rate	NOUN
admet-661	349	15	of	of	ADP
admet-661	349	16	cocrystal	cocrystal	ADJ
admet-661	349	17	and	and	CCONJ
admet-661	349	18	their	their	PRON
admet-661	349	19	free	free	ADJ
admet-661	349	20	base	base	NOUN
admet-661	349	21	form	form	NOUN
admet-661	349	22	,	,	PUNCT
admet-661	349	23	we	we	PRON
admet-661	349	24	have	have	AUX
admet-661	349	25	outlined	outline	VERB
admet-661	349	26	in	in	ADP
admet-661	349	27	introduction	introduction	NOUN
admet-661	349	28	of	of	ADP
admet-661	349	29	the	the	DET
admet-661	349	30	paper	paper	NOUN
admet-661	349	31	several	several	ADJ
admet-661	349	32	objectives	objective	NOUN
admet-661	349	33	for	for	ADP
admet-661	349	34	the	the	DET
admet-661	349	35	present	present	ADJ
admet-661	349	36	investigation	investigation	NOUN
admet-661	349	37	.	.	PUNCT
admet-661	350	1	our	our	PRON
admet-661	350	2	findings	finding	NOUN
admet-661	350	3	and	and	CCONJ
admet-661	350	4	conclusions	conclusion	NOUN
admet-661	350	5	against	against	ADP
admet-661	350	6	those	those	DET
admet-661	350	7	objectives	objective	NOUN
admet-661	350	8	are	be	AUX
admet-661	350	9	summarized	summarize	VERB
admet-661	350	10	below	below	ADP
admet-661	350	11	:	:	PUNCT
admet-661	350	12	a	a	X
admet-661	350	13	)	)	PUNCT
admet-661	350	14	comparative	comparative	ADJ
admet-661	350	15	solubility	solubility	NOUN
admet-661	350	16	of	of	ADP
admet-661	350	17	free	free	ADJ
admet-661	350	18	base	base	NOUN
admet-661	350	19	and	and	CCONJ
admet-661	350	20	cocrystals	cocrystal	NOUN
admet-661	350	21	as	as	ADP
admet-661	350	22	a	a	DET
admet-661	350	23	function	function	NOUN
admet-661	350	24	of	of	ADP
admet-661	350	25	ph	ph	ADJ
admet-661	350	26	–	–	PUNCT
admet-661	350	27	ph	ph	ADJ
admet-661	350	28	-	-	PUNCT
admet-661	350	29	solubility	solubility	NOUN
admet-661	350	30	profiles	profile	NOUN
admet-661	350	31	of	of	ADP
admet-661	350	32	ketoconazole	ketoconazole	PROPN
admet-661	350	33	cocrystals	cocrystal	NOUN
admet-661	350	34	with	with	ADP
admet-661	350	35	fumaric	fumaric	ADJ
admet-661	350	36	acid	acid	PROPN
admet-661	350	37	and	and	CCONJ
admet-661	350	38	succinic	succinic	ADJ
admet-661	350	39	showed	show	VERB
admet-661	350	40	phmax	phmax	PROPN
admet-661	350	41	(	(	PUNCT
admet-661	350	42	ph	ph	NOUN
admet-661	350	43	of	of	ADP
admet-661	350	44	maximum	maximum	ADJ
admet-661	350	45	solubility	solubility	NOUN
admet-661	350	46	)	)	PUNCT
admet-661	350	47	at	at	ADP
admet-661	350	48	ph	ph	X
admet-661	350	49	~	~	PUNCT
admet-661	350	50	3.5	3.5	NUM
admet-661	350	51	-	-	SYM
admet-661	350	52	4.0	4.0	NUM
admet-661	350	53	.	.	PUNCT
admet-661	351	1	under	under	ADP
admet-661	351	2	ph	ph	ADJ
admet-661	351	3	conditions	condition	NOUN
admet-661	351	4	above	above	ADP
admet-661	351	5	phmax	phmax	NOUN
admet-661	351	6	,	,	PUNCT
admet-661	351	7	the	the	DET
admet-661	351	8	solubility	solubility	NOUN
admet-661	351	9	profiles	profile	NOUN
admet-661	351	10	were	be	AUX
admet-661	351	11	identical	identical	ADJ
admet-661	351	12	whether	whether	SCONJ
admet-661	351	13	fumaric	fumaric	ADJ
admet-661	351	14	acid	acid	NOUN
admet-661	351	15	,	,	PUNCT
admet-661	351	16	succinic	succinic	ADJ
admet-661	351	17	acid	acid	NOUN
admet-661	351	18	,	,	PUNCT
admet-661	351	19	hcl	hcl	PROPN
admet-661	351	20	or	or	CCONJ
admet-661	351	21	naoh	naoh	NOUN
admet-661	351	22	were	be	AUX
admet-661	351	23	used	use	VERB
admet-661	351	24	to	to	PART
admet-661	351	25	adjust	adjust	VERB
admet-661	351	26	ph	ph	NOUN
admet-661	351	27	,	,	PUNCT
admet-661	351	28	and	and	CCONJ
admet-661	351	29	the	the	DET
admet-661	351	30	profiles	profile	NOUN
admet-661	351	31	were	be	AUX
admet-661	351	32	also	also	ADV
admet-661	351	33	similar	similar	ADJ
admet-661	351	34	whether	whether	SCONJ
admet-661	351	35	the	the	DET
admet-661	351	36	free	free	ADJ
admet-661	351	37	base	base	NOUN
admet-661	351	38	or	or	CCONJ
admet-661	351	39	cocrystals	cocrystal	NOUN
admet-661	351	40	were	be	AUX
admet-661	351	41	used	use	VERB
admet-661	351	42	as	as	ADP
admet-661	351	43	starting	start	VERB
admet-661	351	44	materials	material	NOUN
admet-661	351	45	to	to	PART
admet-661	351	46	determine	determine	VERB
admet-661	351	47	solubility	solubility	NOUN
admet-661	351	48	.	.	PUNCT
admet-661	352	1	at	at	ADP
admet-661	352	2	ph	ph	NOUN
admet-661	352	3	<	<	X
admet-661	352	4	phmax	phmax	NOUN
admet-661	352	5	,	,	PUNCT
admet-661	352	6	the	the	DET
admet-661	352	7	solubility	solubility	NOUN
admet-661	352	8	decreased	decrease	VERB
admet-661	352	9	in	in	ADP
admet-661	352	10	case	case	NOUN
admet-661	352	11	of	of	ADP
admet-661	352	12	the	the	DET
admet-661	352	13	addition	addition	NOUN
admet-661	352	14	of	of	ADP
admet-661	352	15	fumaric	fumaric	ADJ
admet-661	352	16	acid	acid	PROPN
admet-661	352	17	and	and	CCONJ
admet-661	352	18	succinic	succinic	ADJ
admet-661	352	19	acid	acid	NOUN
admet-661	352	20	due	due	ADP
admet-661	352	21	to	to	ADP
admet-661	352	22	the	the	DET
admet-661	352	23	formation	formation	NOUN
admet-661	352	24	of	of	ADP
admet-661	352	25	cocrystals	cocrystal	NOUN
admet-661	352	26	,	,	PUNCT
admet-661	352	27	while	while	SCONJ
admet-661	352	28	the	the	DET
admet-661	352	29	solubility	solubility	NOUN
admet-661	352	30	continued	continue	VERB
admet-661	352	31	to	to	PART
admet-661	352	32	increase	increase	VERB
admet-661	352	33	when	when	SCONJ
admet-661	352	34	hcl	hcl	PROPN
admet-661	352	35	was	be	AUX
admet-661	352	36	added	add	VERB
admet-661	352	37	to	to	ADP
admet-661	352	38	lower	low	ADJ
admet-661	352	39	ph	ph	NOUN
admet-661	352	40	as	as	SCONJ
admet-661	352	41	no	no	DET
admet-661	352	42	cocrystal	cocrystal	ADJ
admet-661	352	43	or	or	CCONJ
admet-661	352	44	salt	salt	NOUN
admet-661	352	45	were	be	AUX
admet-661	352	46	formed	form	VERB
admet-661	352	47	.	.	PUNCT
admet-661	353	1	thus	thus	ADV
admet-661	353	2	,	,	PUNCT
admet-661	353	3	above	above	ADP
admet-661	353	4	phmax	phmax	X
admet-661	353	5	(	(	PUNCT
admet-661	353	6	in	in	ADP
admet-661	353	7	this	this	DET
admet-661	353	8	case	case	NOUN
admet-661	353	9	ph~4	ph~4	NOUN
admet-661	353	10	)	)	PUNCT
admet-661	353	11	,	,	PUNCT
admet-661	353	12	there	there	PRON
admet-661	353	13	is	be	VERB
admet-661	353	14	no	no	DET
admet-661	353	15	solubility	solubility	NOUN
admet-661	353	16	advantage	advantage	NOUN
admet-661	353	17	of	of	ADP
admet-661	353	18	cocrystal	cocrystal	ADJ
admet-661	353	19	formation	formation	NOUN
admet-661	353	20	if	if	SCONJ
admet-661	353	21	the	the	DET
admet-661	353	22	ph	ph	NOUN
admet-661	353	23	is	be	AUX
admet-661	353	24	maintained	maintain	VERB
admet-661	353	25	the	the	DET
admet-661	353	26	same	same	ADJ
admet-661	353	27	,	,	PUNCT
admet-661	353	28	and	and	CCONJ
admet-661	353	29	the	the	DET
admet-661	353	30	solubility	solubility	NOUN
admet-661	353	31	may	may	AUX
admet-661	353	32	differ	differ	VERB
admet-661	353	33	only	only	ADV
admet-661	353	34	if	if	SCONJ
admet-661	353	35	ph	ph	NOUN
admet-661	353	36	of	of	ADP
admet-661	353	37	saturated	saturate	VERB
admet-661	353	38	solutions	solution	NOUN
admet-661	353	39	of	of	ADP
admet-661	353	40	free	free	ADJ
admet-661	353	41	base	base	NOUN
admet-661	353	42	and	and	CCONJ
admet-661	353	43	cocrystals	cocrystal	NOUN
admet-661	353	44	also	also	ADV
admet-661	353	45	differ	differ	VERB
admet-661	353	46	.	.	PUNCT
admet-661	354	1	usually	usually	ADV
admet-661	354	2	,	,	PUNCT
admet-661	354	3	ph	ph	ADJ
admet-661	354	4	values	value	NOUN
admet-661	354	5	of	of	ADP
admet-661	354	6	the	the	DET
admet-661	354	7	suspensions	suspension	NOUN
admet-661	354	8	of	of	ADP
admet-661	354	9	cocrystals	cocrystal	NOUN
admet-661	354	10	in	in	ADP
admet-661	354	11	water	water	NOUN
admet-661	354	12	are	be	AUX
admet-661	354	13	lower	low	ADJ
admet-661	354	14	than	than	ADP
admet-661	354	15	those	those	PRON
admet-661	354	16	of	of	ADP
admet-661	354	17	the	the	DET
admet-661	354	18	free	free	ADJ
admet-661	354	19	base	base	NOUN
admet-661	354	20	in	in	ADP
admet-661	354	21	water	water	NOUN
admet-661	354	22	,	,	PUNCT
admet-661	354	23	and	and	CCONJ
admet-661	354	24	,	,	PUNCT
admet-661	354	25	as	as	ADP
admet-661	354	26	a	a	DET
admet-661	354	27	result	result	NOUN
admet-661	354	28	,	,	PUNCT
admet-661	354	29	cocrystals	cocrystal	NOUN
admet-661	354	30	usually	usually	ADV
admet-661	354	31	exhibit	exhibit	VERB
admet-661	354	32	higher	high	ADJ
admet-661	354	33	solubility	solubility	NOUN
admet-661	354	34	.	.	PUNCT
admet-661	355	1	b	b	X
admet-661	355	2	)	)	PUNCT
admet-661	355	3	solid	solid	ADJ
admet-661	355	4	phases	phase	NOUN
admet-661	355	5	in	in	ADP
admet-661	355	6	equilibria	equilibrium	NOUN
admet-661	355	7	with	with	ADP
admet-661	355	8	saturated	saturate	VERB
admet-661	355	9	solutions	solution	NOUN
admet-661	355	10	–	–	PUNCT
admet-661	355	11	during	during	ADP
admet-661	355	12	the	the	DET
admet-661	355	13	determination	determination	NOUN
admet-661	355	14	of	of	ADP
admet-661	355	15	ph	ph	ADJ
admet-661	355	16	-	-	PUNCT
admet-661	355	17	solubility	solubility	NOUN
admet-661	355	18	profiles	profile	NOUN
admet-661	355	19	of	of	ADP
admet-661	355	20	ketoconazole	ketoconazole	NOUN
admet-661	355	21	by	by	ADP
admet-661	355	22	adding	add	VERB
admet-661	355	23	fumaric	fumaric	ADJ
admet-661	355	24	acid	acid	PROPN
admet-661	355	25	,	,	PUNCT
admet-661	355	26	succinic	succinic	ADJ
admet-661	355	27	acid	acid	NOUN
admet-661	355	28	or	or	CCONJ
admet-661	355	29	hcl	hcl	PROPN
admet-661	355	30	,	,	PUNCT
admet-661	355	31	the	the	DET
admet-661	355	32	solubility	solubility	NOUN
admet-661	355	33	continued	continue	VERB
admet-661	355	34	to	to	PART
admet-661	355	35	increase	increase	VERB
admet-661	355	36	according	accord	VERB
admet-661	355	37	to	to	ADP
admet-661	355	38	the	the	DET
admet-661	355	39	henderson	henderson	PROPN
admet-661	355	40	-	-	PUNCT
admet-661	355	41	hasselbalch	hasselbalch	PROPN
admet-661	355	42	equation	equation	NOUN
admet-661	355	43	and	and	CCONJ
admet-661	355	44	the	the	DET
admet-661	355	45	solid	solid	ADJ
admet-661	355	46	phase	phase	NOUN
admet-661	355	47	in	in	ADP
admet-661	355	48	equilibria	equilibrium	NOUN
admet-661	355	49	with	with	ADP
admet-661	355	50	solutions	solution	NOUN
admet-661	355	51	was	be	AUX
admet-661	355	52	only	only	ADV
admet-661	355	53	the	the	DET
admet-661	355	54	free	free	ADJ
admet-661	355	55	base	base	NOUN
admet-661	355	56	.	.	PUNCT
admet-661	356	1	after	after	ADP
admet-661	356	2	reaching	reach	VERB
admet-661	356	3	a	a	DET
admet-661	356	4	relatively	relatively	ADV
admet-661	356	5	high	high	ADJ
admet-661	356	6	solubility	solubility	NOUN
admet-661	356	7	at	at	ADP
admet-661	356	8	a	a	DET
admet-661	356	9	certain	certain	ADJ
admet-661	356	10	ph	ph	NOUN
admet-661	356	11	during	during	ADP
admet-661	356	12	the	the	DET
admet-661	356	13	addition	addition	NOUN
admet-661	356	14	fumaric	fumaric	PROPN
admet-661	356	15	acid	acid	PROPN
admet-661	356	16	or	or	CCONJ
admet-661	356	17	succinic	succinic	ADJ
admet-661	356	18	acid	acid	NOUN
admet-661	356	19	,	,	PUNCT
admet-661	356	20	which	which	PRON
admet-661	356	21	may	may	AUX
admet-661	356	22	be	be	AUX
admet-661	356	23	referred	refer	VERB
admet-661	356	24	to	to	ADP
admet-661	356	25	as	as	ADP
admet-661	356	26	phmax	phmax	ADJ
admet-661	356	27	or	or	CCONJ
admet-661	356	28	the	the	DET
admet-661	356	29	ph	ph	NOUN
admet-661	356	30	of	of	ADP
admet-661	356	31	maximum	maximum	ADJ
admet-661	356	32	solubility	solubility	NOUN
admet-661	356	33	,	,	PUNCT
admet-661	356	34	the	the	DET
admet-661	356	35	cocrystal	cocrystal	NOUN
admet-661	356	36	precipitated	precipitate	VERB
admet-661	356	37	out	out	ADP
admet-661	356	38	.	.	PUNCT
admet-661	357	1	initially	initially	ADV
admet-661	357	2	,	,	PUNCT
admet-661	357	3	the	the	DET
admet-661	357	4	precipitate	precipitate	NOUN
admet-661	357	5	was	be	AUX
admet-661	357	6	a	a	DET
admet-661	357	7	mixture	mixture	NOUN
admet-661	357	8	of	of	ADP
admet-661	357	9	cocrystal	cocrystal	ADJ
admet-661	357	10	and	and	CCONJ
admet-661	357	11	free	free	ADJ
admet-661	357	12	base	base	NOUN
admet-661	357	13	as	as	ADP
admet-661	357	14	the	the	DET
admet-661	357	15	conversion	conversion	NOUN
admet-661	357	16	of	of	ADP
admet-661	357	17	free	free	ADJ
admet-661	357	18	base	base	NOUN
admet-661	357	19	to	to	PART
admet-661	357	20	cocrystal	cocrystal	VERB
admet-661	357	21	in	in	ADP
admet-661	357	22	the	the	DET
admet-661	357	23	excess	excess	ADJ
admet-661	357	24	solid	solid	ADJ
admet-661	357	25	present	present	NOUN
admet-661	357	26	was	be	AUX
admet-661	357	27	relatively	relatively	ADV
admet-661	357	28	slow	slow	ADJ
admet-661	357	29	.	.	PUNCT
admet-661	358	1	when	when	SCONJ
admet-661	358	2	the	the	DET
admet-661	358	3	ph	ph	VERB
admet-661	358	4	-	-	PUNCT
admet-661	358	5	solubility	solubility	NOUN
admet-661	358	6	profile	profile	NOUN
admet-661	358	7	was	be	AUX
admet-661	358	8	determined	determine	VERB
admet-661	358	9	by	by	ADP
admet-661	358	10	adding	add	VERB
admet-661	358	11	hcl	hcl	PROPN
admet-661	358	12	,	,	PUNCT
admet-661	358	13	instead	instead	ADV
admet-661	358	14	of	of	ADP
admet-661	358	15	the	the	DET
admet-661	358	16	addition	addition	NOUN
admet-661	358	17	of	of	ADP
admet-661	358	18	fumaric	fumaric	ADJ
admet-661	358	19	acid	acid	PROPN
admet-661	358	20	or	or	CCONJ
admet-661	358	21	succinic	succinic	ADJ
admet-661	358	22	acid	acid	NOUN
admet-661	358	23	,	,	PUNCT
admet-661	358	24	free	free	ADJ
admet-661	358	25	ketoconazole	ketoconazole	NOUN
admet-661	358	26	base	base	NOUN
admet-661	358	27	was	be	AUX
admet-661	358	28	always	always	ADV
admet-661	358	29	the	the	DET
admet-661	358	30	equilibrium	equilibrium	NOUN
admet-661	358	31	species	specie	NOUN
admet-661	358	32	as	as	ADP
admet-661	358	33	no	no	DET
admet-661	358	34	cocrystals	cocrystal	NOUN
admet-661	358	35	or	or	CCONJ
admet-661	358	36	salts	salt	NOUN
admet-661	358	37	were	be	AUX
admet-661	358	38	formed	form	VERB
admet-661	358	39	.	.	PUNCT
admet-661	359	1	when	when	SCONJ
admet-661	359	2	cocrystals	cocrystal	NOUN
admet-661	359	3	were	be	AUX
admet-661	359	4	used	use	VERB
admet-661	359	5	as	as	ADP
admet-661	359	6	starting	start	VERB
admet-661	359	7	materials	material	NOUN
admet-661	359	8	,	,	PUNCT
admet-661	359	9	instead	instead	ADV
admet-661	359	10	of	of	ADP
admet-661	359	11	the	the	DET
admet-661	359	12	free	free	ADJ
admet-661	359	13	base	base	NOUN
admet-661	359	14	,	,	PUNCT
admet-661	359	15	for	for	ADP
admet-661	359	16	the	the	DET
admet-661	359	17	determination	determination	NOUN
admet-661	359	18	of	of	ADP
admet-661	359	19	phsolubility	phsolubility	NOUN
admet-661	359	20	profile	profile	NOUN
admet-661	359	21	,	,	PUNCT
admet-661	359	22	the	the	DET
admet-661	359	23	excess	excess	ADJ
admet-661	359	24	solids	solid	NOUN
admet-661	359	25	at	at	ADP
admet-661	359	26	phmax	phmax	PROPN
admet-661	359	27	and	and	CCONJ
admet-661	359	28	lower	low	ADJ
admet-661	359	29	were	be	AUX
admet-661	359	30	only	only	ADV
admet-661	359	31	cocrystals	cocrystal	NOUN
admet-661	359	32	,	,	PUNCT
admet-661	359	33	and	and	CCONJ
admet-661	359	34	mixtures	mixture	NOUN
admet-661	359	35	of	of	ADP
admet-661	359	36	cocrystals	cocrystal	NOUN
admet-661	359	37	and	and	CCONJ
admet-661	359	38	free	free	ADJ
admet-661	359	39	base	base	NOUN
admet-661	359	40	were	be	AUX
admet-661	359	41	present	present	ADJ
admet-661	359	42	when	when	SCONJ
admet-661	359	43	the	the	DET
admet-661	359	44	ph	ph	NOUN
admet-661	359	45	was	be	AUX
admet-661	359	46	raised	raise	VERB
admet-661	359	47	above	above	ADP
admet-661	359	48	phmax	phmax	NOUN
admet-661	359	49	.	.	PUNCT
admet-661	360	1	thus	thus	ADV
admet-661	360	2	,	,	PUNCT
admet-661	360	3	the	the	DET
admet-661	360	4	conversion	conversion	NOUN
admet-661	360	5	from	from	ADP
admet-661	360	6	free	free	ADJ
admet-661	360	7	base	base	NOUN
admet-661	360	8	to	to	PART
admet-661	360	9	cocrystal	cocrystal	VERB
admet-661	360	10	and	and	CCONJ
admet-661	360	11	vice	vice	PROPN
admet-661	360	12	versa	versa	ADV
admet-661	360	13	occur	occur	VERB
admet-661	360	14	,	,	PUNCT
admet-661	360	15	respectively	respectively	ADV
admet-661	360	16	,	,	PUNCT
admet-661	360	17	when	when	SCONJ
admet-661	360	18	the	the	DET
admet-661	360	19	ph	ph	NOUN
admet-661	360	20	is	be	AUX
admet-661	360	21	decreased	decrease	VERB
admet-661	360	22	below	below	ADV
admet-661	360	23	or	or	CCONJ
admet-661	360	24	increased	increase	VERB
admet-661	360	25	above	above	ADP
admet-661	360	26	the	the	DET
admet-661	360	27	phmax	phmax	NOUN
admet-661	360	28	.	.	PUNCT
admet-661	361	1	c	c	X
admet-661	361	2	)	)	PUNCT
admet-661	361	3	similarity	similarity	NOUN
admet-661	361	4	in	in	ADP
admet-661	361	5	ph	ph	PROPN
admet-661	361	6	vs	vs	ADP
admet-661	361	7	solubility	solubility	NOUN
admet-661	361	8	profiles	profile	NOUN
admet-661	361	9	of	of	ADP
admet-661	361	10	cocrystals	cocrystal	NOUN
admet-661	361	11	and	and	CCONJ
admet-661	361	12	salt	salt	NOUN
admet-661	361	13	–	–	PUNCT
admet-661	361	14	ph	ph	ADJ
admet-661	361	15	-	-	PUNCT
admet-661	361	16	solubility	solubility	NOUN
admet-661	361	17	profiles	profile	NOUN
admet-661	361	18	of	of	ADP
admet-661	361	19	ketoconazolefumaric	ketoconazolefumaric	NOUN
admet-661	361	20	acid	acid	NOUN
admet-661	361	21	and	and	CCONJ
admet-661	361	22	ketoconazole	ketoconazole	NOUN
admet-661	361	23	-	-	PUNCT
admet-661	361	24	succinic	succinic	ADJ
admet-661	361	25	acid	acid	NOUN
admet-661	361	26	cocrystals	cocrystal	NOUN
admet-661	361	27	obtained	obtain	VERB
admet-661	361	28	in	in	ADP
admet-661	361	29	the	the	DET
admet-661	361	30	present	present	ADJ
admet-661	361	31	investigation	investigation	NOUN
admet-661	361	32	appeared	appear	VERB
admet-661	361	33	to	to	PART
admet-661	361	34	be	be	AUX
admet-661	361	35	similar	similar	ADJ
admet-661	361	36	to	to	ADP
admet-661	361	37	ph	ph	ADJ
admet-661	361	38	-	-	PUNCT
admet-661	361	39	solubility	solubility	NOUN
admet-661	361	40	profiles	profile	NOUN
admet-661	361	41	commonly	commonly	ADV
admet-661	361	42	encountered	encounter	VERB
admet-661	361	43	with	with	ADP
admet-661	361	44	salts	salt	NOUN
admet-661	361	45	.	.	PUNCT
admet-661	362	1	in	in	ADP
admet-661	362	2	both	both	DET
admet-661	362	3	cases	case	NOUN
admet-661	362	4	,	,	PUNCT
admet-661	362	5	there	there	PRON
admet-661	362	6	are	be	VERB
admet-661	362	7	phmax	phmax	NOUN
admet-661	362	8	(	(	PUNCT
admet-661	362	9	the	the	DET
admet-661	362	10	ph	ph	NOUN
admet-661	362	11	of	of	ADP
admet-661	362	12	maximum	maximum	ADJ
admet-661	362	13	solubility	solubility	NOUN
admet-661	362	14	)	)	PUNCT
admet-661	362	15	and	and	CCONJ
admet-661	362	16	the	the	DET
admet-661	362	17	free	free	ADJ
admet-661	362	18	base	base	NOUN
admet-661	362	19	is	be	AUX
admet-661	362	20	the	the	DET
admet-661	362	21	equilibrium	equilibrium	NOUN
admet-661	362	22	species	specie	NOUN
admet-661	362	23	at	at	ADP
admet-661	362	24	ph	ph	VERB
admet-661	362	25	>	>	X
admet-661	362	26	phmax	phmax	NOUN
admet-661	362	27	.	.	PUNCT
admet-661	363	1	the	the	DET
admet-661	363	2	only	only	ADJ
admet-661	363	3	difference	difference	NOUN
admet-661	363	4	between	between	ADP
admet-661	363	5	the	the	DET
admet-661	363	6	solubility	solubility	NOUN
admet-661	363	7	profiles	profile	NOUN
admet-661	363	8	of	of	ADP
admet-661	363	9	cocrystals	cocrystal	NOUN
admet-661	363	10	and	and	CCONJ
admet-661	363	11	salts	salt	NOUN
admet-661	363	12	is	be	AUX
admet-661	363	13	the	the	DET
admet-661	363	14	nature	nature	NOUN
admet-661	363	15	of	of	ADP
admet-661	363	16	solid	solid	ADJ
admet-661	363	17	phases	phase	NOUN
admet-661	363	18	at	at	ADP
admet-661	363	19	vasoya	vasoya	PROPN
admet-661	363	20	et	et	PROPN
admet-661	363	21	al	al	PROPN
admet-661	363	22	.	.	PROPN
admet-661	363	23	admet	admet	PROPN
admet-661	363	24	&	&	CCONJ
admet-661	363	25	dmpk	dmpk	PROPN
admet-661	363	26	7(2	7(2	NUM
admet-661	363	27	)	)	PUNCT
admet-661	363	28	(	(	PUNCT
admet-661	363	29	2019	2019	NUM
admet-661	363	30	)	)	PUNCT
admet-661	363	31	106	106	NUM
admet-661	363	32	-	-	SYM
admet-661	363	33	130	130	NUM
admet-661	363	34	126	126	NUM
admet-661	363	35	ph	ph	NOUN
admet-661	363	36	<	<	X
admet-661	363	37	phmax	phmax	X
admet-661	363	38	;	;	PUNCT
admet-661	363	39	it	it	PRON
admet-661	363	40	is	be	AUX
admet-661	363	41	cocrystal	cocrystal	ADJ
admet-661	363	42	in	in	ADP
admet-661	363	43	the	the	DET
admet-661	363	44	ph	ph	VERB
admet-661	363	45	-	-	PUNCT
admet-661	363	46	solubility	solubility	NOUN
admet-661	363	47	profile	profile	NOUN
admet-661	363	48	of	of	ADP
admet-661	363	49	cocrystal	cocrystal	NOUN
admet-661	363	50	,	,	PUNCT
admet-661	363	51	while	while	SCONJ
admet-661	363	52	salt	salt	NOUN
admet-661	363	53	is	be	AUX
admet-661	363	54	the	the	DET
admet-661	363	55	equilibrium	equilibrium	NOUN
admet-661	363	56	species	specie	NOUN
admet-661	363	57	in	in	ADP
admet-661	363	58	the	the	DET
admet-661	363	59	ph	ph	ADJ
admet-661	363	60	-	-	PUNCT
admet-661	363	61	solubility	solubility	NOUN
admet-661	363	62	profile	profile	NOUN
admet-661	363	63	of	of	ADP
admet-661	363	64	salt	salt	NOUN
admet-661	363	65	.	.	PUNCT
admet-661	364	1	considering	consider	VERB
admet-661	364	2	the	the	DET
admet-661	364	3	phenomenon	phenomenon	NOUN
admet-661	364	4	in	in	ADP
admet-661	364	5	another	another	DET
admet-661	364	6	way	way	NOUN
admet-661	364	7	,	,	PUNCT
admet-661	364	8	the	the	DET
admet-661	364	9	two	two	NUM
admet-661	364	10	solid	solid	ADJ
admet-661	364	11	phases	phase	NOUN
admet-661	364	12	at	at	ADP
admet-661	364	13	ph	ph	ADJ
admet-661	364	14	<	<	X
admet-661	364	15	phmax	phmax	X
admet-661	364	16	have	have	VERB
admet-661	364	17	certain	certain	ADJ
admet-661	364	18	similarities	similarity	NOUN
admet-661	364	19	as	as	SCONJ
admet-661	364	20	both	both	PRON
admet-661	364	21	are	be	AUX
admet-661	364	22	complexes	complex	NOUN
admet-661	364	23	,	,	PUNCT
admet-661	364	24	the	the	DET
admet-661	364	25	cocrystal	cocrystal	ADJ
admet-661	364	26	being	be	AUX
admet-661	364	27	an	an	DET
admet-661	364	28	acid	acid	NOUN
admet-661	364	29	-	-	PUNCT
admet-661	364	30	base	base	NOUN
admet-661	364	31	nonionic	nonionic	ADJ
admet-661	364	32	complex	complex	NOUN
admet-661	364	33	and	and	CCONJ
admet-661	364	34	salt	salt	NOUN
admet-661	364	35	being	be	AUX
admet-661	364	36	an	an	DET
admet-661	364	37	acid	acid	ADJ
admet-661	364	38	-	-	PUNCT
admet-661	364	39	base	base	NOUN
admet-661	364	40	ionic	ionic	ADJ
admet-661	364	41	complex	complex	NOUN
admet-661	364	42	.	.	PUNCT
admet-661	365	1	accordingly	accordingly	ADV
admet-661	365	2	,	,	PUNCT
admet-661	365	3	since	since	SCONJ
admet-661	365	4	both	both	CCONJ
admet-661	365	5	cocrystal	cocrystal	ADJ
admet-661	365	6	and	and	CCONJ
admet-661	365	7	salt	salt	NOUN
admet-661	365	8	are	be	AUX
admet-661	365	9	solid	solid	ADJ
admet-661	365	10	complexes	complex	NOUN
admet-661	365	11	with	with	ADP
admet-661	365	12	definite	definite	ADJ
admet-661	365	13	stoichiometric	stoichiometric	ADJ
admet-661	365	14	ratios	ratio	NOUN
admet-661	365	15	between	between	ADP
admet-661	365	16	basic	basic	ADJ
admet-661	365	17	drugs	drug	NOUN
admet-661	365	18	with	with	ADP
admet-661	365	19	acidic	acidic	ADJ
admet-661	365	20	conformer	conformer	NOUN
admet-661	365	21	or	or	CCONJ
admet-661	365	22	counter	counter	NOUN
admet-661	365	23	ion	ion	NOUN
admet-661	365	24	,	,	PUNCT
admet-661	365	25	the	the	DET
admet-661	365	26	cocrystal	cocrystal	NOUN
admet-661	365	27	may	may	AUX
admet-661	365	28	be	be	AUX
admet-661	365	29	considered	consider	VERB
admet-661	365	30	as	as	ADP
admet-661	365	31	a	a	DET
admet-661	365	32	new	new	ADJ
admet-661	365	33	chemical	chemical	NOUN
admet-661	365	34	entity	entity	NOUN
admet-661	365	35	similar	similar	ADJ
admet-661	365	36	to	to	ADP
admet-661	365	37	a	a	DET
admet-661	365	38	salt	salt	NOUN
admet-661	365	39	.	.	PUNCT
admet-661	366	1	d	d	X
admet-661	366	2	)	)	PUNCT
admet-661	366	3	cocrystal	cocrystal	ADJ
admet-661	366	4	vs	vs	ADP
admet-661	366	5	free	free	ADJ
admet-661	366	6	base	base	NOUN
admet-661	366	7	intrinsic	intrinsic	ADJ
admet-661	366	8	dissolution	dissolution	NOUN
admet-661	366	9	rates	rate	NOUN
admet-661	366	10	–	–	PUNCT
admet-661	366	11	although	although	SCONJ
admet-661	366	12	the	the	DET
admet-661	366	13	solubility	solubility	NOUN
admet-661	366	14	of	of	ADP
admet-661	366	15	cocrystals	cocrystal	NOUN
admet-661	366	16	and	and	CCONJ
admet-661	366	17	the	the	DET
admet-661	366	18	free	free	ADJ
admet-661	366	19	base	base	NOUN
admet-661	366	20	were	be	AUX
admet-661	366	21	identical	identical	ADJ
admet-661	366	22	at	at	ADP
admet-661	366	23	ph	ph	ADJ
admet-661	366	24	>	>	X
admet-661	366	25	phmax	phmax	NOUN
admet-661	366	26	,	,	PUNCT
admet-661	366	27	their	their	PRON
admet-661	366	28	dissolution	dissolution	NOUN
admet-661	366	29	rates	rate	NOUN
admet-661	366	30	differed	differ	VERB
admet-661	366	31	.	.	PUNCT
admet-661	367	1	dissolution	dissolution	ADJ
admet-661	367	2	rates	rate	NOUN
admet-661	367	3	of	of	ADP
admet-661	367	4	cocrystals	cocrystal	NOUN
admet-661	367	5	were	be	AUX
admet-661	367	6	found	find	VERB
admet-661	367	7	to	to	PART
admet-661	367	8	be	be	AUX
admet-661	367	9	much	much	ADV
admet-661	367	10	higher	high	ADJ
admet-661	367	11	than	than	ADP
admet-661	367	12	that	that	PRON
admet-661	367	13	of	of	ADP
admet-661	367	14	the	the	DET
admet-661	367	15	free	free	ADJ
admet-661	367	16	base	base	NOUN
admet-661	367	17	at	at	ADP
admet-661	367	18	such	such	ADJ
admet-661	367	19	ph	ph	NOUN
admet-661	367	20	due	due	ADP
admet-661	367	21	to	to	ADP
admet-661	367	22	the	the	DET
admet-661	367	23	modulation	modulation	NOUN
admet-661	367	24	of	of	ADP
admet-661	367	25	microenvironmental	microenvironmental	ADJ
admet-661	367	26	ph	ph	NOUN
admet-661	367	27	at	at	ADP
admet-661	367	28	the	the	DET
admet-661	367	29	dissolving	dissolve	VERB
admet-661	367	30	surface	surface	NOUN
admet-661	367	31	of	of	ADP
admet-661	367	32	cocrystals	cocrystal	NOUN
admet-661	367	33	.	.	PUNCT
admet-661	368	1	for	for	ADP
admet-661	368	2	example	example	NOUN
admet-661	368	3	,	,	PUNCT
admet-661	368	4	at	at	ADP
admet-661	368	5	ph	ph	PROPN
admet-661	368	6	5	5	NUM
admet-661	368	7	,	,	PUNCT
admet-661	368	8	the	the	DET
admet-661	368	9	dissolution	dissolution	ADJ
admet-661	368	10	rate	rate	NOUN
admet-661	368	11	of	of	ADP
admet-661	368	12	the	the	DET
admet-661	368	13	cocrystal	cocrystal	NOUN
admet-661	368	14	was	be	AUX
admet-661	368	15	higher	high	ADJ
admet-661	368	16	than	than	ADP
admet-661	368	17	that	that	PRON
admet-661	368	18	of	of	ADP
admet-661	368	19	the	the	DET
admet-661	368	20	free	free	ADJ
admet-661	368	21	base	base	NOUN
admet-661	368	22	,	,	PUNCT
admet-661	368	23	because	because	SCONJ
admet-661	368	24	the	the	DET
admet-661	368	25	ph	ph	NOUN
admet-661	368	26	at	at	ADP
admet-661	368	27	the	the	DET
admet-661	368	28	surface	surface	NOUN
admet-661	368	29	of	of	ADP
admet-661	368	30	cocrystal	cocrystal	NOUN
admet-661	368	31	was	be	AUX
admet-661	368	32	lower	low	ADJ
admet-661	368	33	than	than	ADP
admet-661	368	34	5	5	NUM
admet-661	368	35	,	,	PUNCT
admet-661	368	36	where	where	SCONJ
admet-661	368	37	the	the	DET
admet-661	368	38	solubility	solubility	NOUN
admet-661	368	39	of	of	ADP
admet-661	368	40	ketoconazole	ketoconazole	NOUN
admet-661	368	41	was	be	AUX
admet-661	368	42	much	much	ADV
admet-661	368	43	higher	high	ADJ
admet-661	368	44	.	.	PUNCT
admet-661	369	1	it	it	PRON
admet-661	369	2	was	be	AUX
admet-661	369	3	also	also	ADV
admet-661	369	4	predicted	predict	VERB
admet-661	369	5	by	by	ADP
admet-661	369	6	determining	determine	VERB
admet-661	369	7	microenvironmental	microenvironmental	ADJ
admet-661	369	8	ph	ph	NOUN
admet-661	369	9	that	that	PRON
admet-661	369	10	the	the	DET
admet-661	369	11	dissolution	dissolution	NOUN
admet-661	369	12	rates	rate	NOUN
admet-661	369	13	of	of	ADP
admet-661	369	14	cocrystals	cocrystal	NOUN
admet-661	369	15	at	at	ADP
admet-661	369	16	ph	ph	PROPN
admet-661	369	17	7	7	NUM
admet-661	369	18	would	would	AUX
admet-661	369	19	also	also	ADV
admet-661	369	20	be	be	AUX
admet-661	369	21	much	much	ADV
admet-661	369	22	higher	high	ADJ
admet-661	369	23	than	than	ADP
admet-661	369	24	that	that	PRON
admet-661	369	25	of	of	ADP
admet-661	369	26	the	the	DET
admet-661	369	27	free	free	ADJ
admet-661	369	28	base	base	NOUN
admet-661	369	29	.	.	PUNCT
admet-661	370	1	thus	thus	ADV
admet-661	370	2	,	,	PUNCT
admet-661	370	3	under	under	ADP
admet-661	370	4	intestinal	intestinal	ADJ
admet-661	370	5	ph	ph	ADJ
admet-661	370	6	conditions	condition	NOUN
admet-661	370	7	,	,	PUNCT
admet-661	370	8	the	the	DET
admet-661	370	9	cocrystals	cocrystal	NOUN
admet-661	370	10	can	can	AUX
admet-661	370	11	have	have	VERB
admet-661	370	12	better	well	ADJ
admet-661	370	13	dissolution	dissolution	NOUN
admet-661	370	14	rates	rate	NOUN
admet-661	370	15	and	and	CCONJ
admet-661	370	16	,	,	PUNCT
admet-661	370	17	possibly	possibly	ADV
admet-661	370	18	,	,	PUNCT
admet-661	370	19	better	well	ADJ
admet-661	370	20	bioavailability	bioavailability	NOUN
admet-661	370	21	.	.	PUNCT
admet-661	371	1	it	it	PRON
admet-661	371	2	is	be	AUX
admet-661	371	3	hoped	hope	VERB
admet-661	371	4	that	that	SCONJ
admet-661	371	5	the	the	DET
admet-661	371	6	results	result	NOUN
admet-661	371	7	presented	present	VERB
admet-661	371	8	in	in	ADP
admet-661	371	9	this	this	DET
admet-661	371	10	report	report	NOUN
admet-661	371	11	will	will	AUX
admet-661	371	12	clarify	clarify	VERB
admet-661	371	13	some	some	PRON
admet-661	371	14	of	of	ADP
admet-661	371	15	the	the	DET
admet-661	371	16	basic	basic	ADJ
admet-661	371	17	concepts	concept	NOUN
admet-661	371	18	with	with	ADP
admet-661	371	19	respect	respect	NOUN
admet-661	371	20	to	to	ADP
admet-661	371	21	solubility	solubility	NOUN
admet-661	371	22	and	and	CCONJ
admet-661	371	23	dissolution	dissolution	NOUN
admet-661	371	24	rates	rate	NOUN
admet-661	371	25	of	of	ADP
admet-661	371	26	cocrystals	cocrystal	NOUN
admet-661	371	27	and	and	CCONJ
admet-661	371	28	will	will	AUX
admet-661	371	29	provide	provide	VERB
admet-661	371	30	a	a	DET
admet-661	371	31	systematic	systematic	ADJ
admet-661	371	32	approach	approach	NOUN
admet-661	371	33	to	to	PART
admet-661	371	34	identify	identify	VERB
admet-661	371	35	and	and	CCONJ
admet-661	371	36	select	select	ADJ
admet-661	371	37	cocrystals	cocrystal	NOUN
admet-661	371	38	for	for	ADP
admet-661	371	39	dosage	dosage	NOUN
admet-661	371	40	form	form	NOUN
admet-661	371	41	development	development	NOUN
admet-661	371	42	.	.	PUNCT
admet-661	372	1	it	it	PRON
admet-661	372	2	should	should	AUX
admet-661	372	3	,	,	PUNCT
admet-661	372	4	however	however	ADV
admet-661	372	5	,	,	PUNCT
admet-661	372	6	be	be	AUX
admet-661	372	7	mentioned	mention	VERB
admet-661	372	8	here	here	ADV
admet-661	372	9	that	that	SCONJ
admet-661	372	10	the	the	DET
admet-661	372	11	results	result	NOUN
admet-661	372	12	may	may	AUX
admet-661	372	13	be	be	AUX
admet-661	372	14	particularly	particularly	ADV
admet-661	372	15	applicable	applicable	ADJ
admet-661	372	16	to	to	ADP
admet-661	372	17	basic	basic	ADJ
admet-661	372	18	drugs	drug	NOUN
admet-661	372	19	that	that	PRON
admet-661	372	20	demonstrate	demonstrate	VERB
admet-661	372	21	ph	ph	ADJ
admet-661	372	22	-	-	ADJ
admet-661	372	23	dependent	dependent	ADJ
admet-661	372	24	profiles	profile	NOUN
admet-661	372	25	in	in	ADP
admet-661	372	26	the	the	DET
admet-661	372	27	gastrointestinal	gastrointestinal	ADJ
admet-661	372	28	ph	ph	ADJ
admet-661	372	29	range	range	NOUN
admet-661	372	30	.	.	PUNCT
admet-661	373	1	the	the	DET
admet-661	373	2	concepts	concept	NOUN
admet-661	373	3	may	may	AUX
admet-661	373	4	also	also	ADV
admet-661	373	5	be	be	AUX
admet-661	373	6	applicable	applicable	ADJ
admet-661	373	7	to	to	ADP
admet-661	373	8	cocrystals	cocrystal	NOUN
admet-661	373	9	of	of	ADP
admet-661	373	10	acidic	acidic	ADJ
admet-661	373	11	compound	compound	NOUN
admet-661	373	12	.	.	PUNCT
admet-661	374	1	however	however	ADV
admet-661	374	2	,	,	PUNCT
admet-661	374	3	they	they	PRON
admet-661	374	4	may	may	AUX
admet-661	374	5	not	not	PART
admet-661	374	6	be	be	AUX
admet-661	374	7	generalized	generalize	VERB
admet-661	374	8	for	for	ADP
admet-661	374	9	cocrystals	cocrystal	NOUN
admet-661	374	10	of	of	ADP
admet-661	374	11	neutral	neutral	ADJ
admet-661	374	12	compounds	compound	NOUN
admet-661	374	13	where	where	SCONJ
admet-661	374	14	no	no	DET
admet-661	374	15	significant	significant	ADJ
admet-661	374	16	change	change	NOUN
admet-661	374	17	in	in	ADP
admet-661	374	18	solubility	solubility	NOUN
admet-661	374	19	as	as	ADP
admet-661	374	20	a	a	DET
admet-661	374	21	function	function	NOUN
admet-661	374	22	of	of	ADP
admet-661	374	23	ph	ph	NOUN
admet-661	374	24	is	be	AUX
admet-661	374	25	observed	observe	VERB
admet-661	374	26	.	.	PUNCT
admet-661	375	1	further	further	ADJ
admet-661	375	2	studies	study	NOUN
admet-661	375	3	with	with	ADP
admet-661	375	4	cocrystals	cocrystal	NOUN
admet-661	375	5	of	of	ADP
admet-661	375	6	relatively	relatively	ADV
admet-661	375	7	neutral	neutral	ADJ
admet-661	375	8	compounds	compound	NOUN
admet-661	375	9	are	be	AUX
admet-661	375	10	currently	currently	ADV
admet-661	375	11	underway	underway	ADJ
admet-661	375	12	in	in	ADP
admet-661	375	13	our	our	PRON
admet-661	375	14	laboratory	laboratory	NOUN
admet-661	375	15	.	.	PUNCT
admet-661	376	1	acknowledgement	acknowledgement	NOUN
admet-661	376	2	:	:	PUNCT
admet-661	376	3	this	this	DET
admet-661	376	4	work	work	NOUN
admet-661	376	5	was	be	AUX
admet-661	376	6	presented	present	VERB
admet-661	376	7	,	,	PUNCT
admet-661	376	8	in	in	ADP
admet-661	376	9	part	part	NOUN
admet-661	376	10	,	,	PUNCT
admet-661	376	11	at	at	ADP
admet-661	376	12	the	the	DET
admet-661	376	13	special	special	ADJ
admet-661	376	14	session	session	NOUN
admet-661	376	15	on	on	ADP
admet-661	376	16	‘	'	PUNCT
admet-661	376	17	pharmaceutical	pharmaceutical	ADJ
admet-661	376	18	cocrystals	cocrystal	NOUN
admet-661	376	19	–	–	PUNCT
admet-661	376	20	physicochemical	physicochemical	ADJ
admet-661	376	21	properties	property	NOUN
admet-661	376	22	and	and	CCONJ
admet-661	376	23	formulations	formulation	NOUN
admet-661	376	24	’	'	PUNCT
admet-661	376	25	held	hold	VERB
admet-661	376	26	at	at	ADP
admet-661	376	27	the	the	DET
admet-661	376	28	6th	6th	ADJ
admet-661	376	29	world	world	NOUN
admet-661	376	30	conference	conference	NOUN
admet-661	376	31	on	on	ADP
admet-661	376	32	physico	physico	NOUN
admet-661	376	33	-	-	PUNCT
admet-661	376	34	chemical	chemical	NOUN
admet-661	376	35	methods	method	NOUN
admet-661	376	36	in	in	ADP
admet-661	376	37	drug	drug	NOUN
admet-661	376	38	discovery	discovery	NOUN
admet-661	376	39	and	and	CCONJ
admet-661	376	40	development	development	NOUN
admet-661	376	41	that	that	PRON
admet-661	376	42	was	be	AUX
admet-661	376	43	organized	organize	VERB
admet-661	376	44	by	by	ADP
admet-661	376	45	international	international	ADJ
admet-661	376	46	association	association	NOUN
admet-661	376	47	of	of	ADP
admet-661	376	48	physical	physical	ADJ
admet-661	376	49	chemists	chemist	NOUN
admet-661	376	50	(	(	PUNCT
admet-661	376	51	iapc-6	iapc-6	NUM
admet-661	376	52	)	)	PUNCT
admet-661	376	53	,	,	PUNCT
admet-661	376	54	at	at	ADP
admet-661	376	55	zagreb	zagreb	PROPN
admet-661	376	56	,	,	PUNCT
admet-661	376	57	croatia	croatia	PROPN
admet-661	376	58	,	,	PUNCT
admet-661	376	59	in	in	ADP
admet-661	376	60	september	september	PROPN
admet-661	376	61	2017	2017	NUM
admet-661	376	62	.	.	PUNCT
admet-661	377	1	further	further	ADJ
admet-661	377	2	studies	study	NOUN
admet-661	377	3	were	be	AUX
admet-661	377	4	conducted	conduct	VERB
admet-661	377	5	based	base	VERB
admet-661	377	6	on	on	ADP
admet-661	377	7	feedback	feedback	NOUN
admet-661	377	8	received	receive	VERB
admet-661	377	9	from	from	ADP
admet-661	377	10	the	the	DET
admet-661	377	11	participants	participant	NOUN
admet-661	377	12	of	of	ADP
admet-661	377	13	the	the	DET
admet-661	377	14	session	session	NOUN
admet-661	377	15	.	.	PUNCT
admet-661	378	1	the	the	DET
admet-661	378	2	author	author	NOUN
admet-661	378	3	abu	abu	PROPN
admet-661	378	4	serajuddin	serajuddin	PROPN
admet-661	378	5	thanks	thanks	PROPN
admet-661	378	6	dr	dr	PROPN
admet-661	378	7	.	.	PROPN
admet-661	378	8	alex	alex	PROPN
admet-661	378	9	avdeef	avdeef	PROPN
admet-661	378	10	(	(	PUNCT
admet-661	378	11	in	in	ADP
admet-661	378	12	-	-	PUNCT
admet-661	378	13	adme	adme	NOUN
admet-661	378	14	research	research	NOUN
admet-661	378	15	,	,	PUNCT
admet-661	378	16	new	new	PROPN
admet-661	378	17	york	york	PROPN
admet-661	378	18	)	)	PUNCT
admet-661	378	19	and	and	CCONJ
admet-661	378	20	prof	prof	PROPN
admet-661	378	21	.	.	PUNCT
admet-661	379	1	zoran	zoran	PROPN
admet-661	379	2	mandić	mandić	PROPN
admet-661	379	3	(	(	PUNCT
admet-661	379	4	university	university	NOUN
admet-661	379	5	of	of	ADP
admet-661	379	6	zagreb	zagreb	PROPN
admet-661	379	7	,	,	PUNCT
admet-661	379	8	croatia	croatia	PROPN
admet-661	379	9	)	)	PUNCT
admet-661	379	10	for	for	ADP
admet-661	379	11	invitation	invitation	NOUN
admet-661	379	12	to	to	ADP
admet-661	379	13	the	the	DET
admet-661	379	14	conference	conference	NOUN
admet-661	379	15	,	,	PUNCT
admet-661	379	16	and	and	CCONJ
admet-661	379	17	he	he	PRON
admet-661	379	18	is	be	AUX
admet-661	379	19	also	also	ADV
admet-661	379	20	grateful	grateful	ADJ
admet-661	379	21	to	to	PART
admet-661	379	22	prof	prof	VERB
admet-661	379	23	.	.	PUNCT
admet-661	380	1	mandić	mandić	PROPN
admet-661	380	2	for	for	ADP
admet-661	380	3	continued	continue	VERB
admet-661	380	4	encouragement	encouragement	NOUN
admet-661	380	5	to	to	PART
admet-661	380	6	write	write	VERB
admet-661	380	7	this	this	DET
admet-661	380	8	paper	paper	NOUN
admet-661	380	9	.	.	PUNCT
admet-661	381	1	conflict	conflict	NOUN
admet-661	381	2	of	of	ADP
admet-661	381	3	interest	interest	NOUN
admet-661	381	4	:	:	PUNCT
admet-661	381	5	authors	author	NOUN
admet-661	381	6	declare	declare	VERB
admet-661	381	7	no	no	DET
admet-661	381	8	conflict	conflict	NOUN
admet-661	381	9	of	of	ADP
admet-661	381	10	interest	interest	NOUN
admet-661	381	11	associated	associate	VERB
admet-661	381	12	with	with	ADP
admet-661	381	13	the	the	DET
admet-661	381	14	present	present	ADJ
admet-661	381	15	research	research	NOUN
admet-661	381	16	work	work	NOUN
admet-661	381	17	.	.	PUNCT
admet-661	382	1	references	reference	NOUN
admet-661	382	2	[	[	X
admet-661	382	3	1	1	X
admet-661	382	4	]	]	PUNCT
admet-661	382	5	j.	j.	PROPN
admet-661	382	6	aaltonen	aaltonen	PROPN
admet-661	382	7	,	,	PUNCT
admet-661	382	8	m.	m.	NOUN
admet-661	382	9	alleso	alleso	PROPN
admet-661	382	10	,	,	PUNCT
admet-661	382	11	s.	s.	PROPN
admet-661	382	12	mirza	mirza	PROPN
admet-661	382	13	,	,	PUNCT
admet-661	382	14	v.	v.	PROPN
admet-661	382	15	koradia	koradia	PROPN
admet-661	382	16	,	,	PUNCT
admet-661	382	17	k.c	k.c	PROPN
admet-661	382	18	.	.	PROPN
admet-661	382	19	gordon	gordon	PROPN
admet-661	382	20	,	,	PUNCT
admet-661	382	21	j.	j.	PROPN
admet-661	382	22	rantanen	rantanen	PROPN
admet-661	382	23	.	.	PUNCT
admet-661	383	1	solid	solid	ADJ
admet-661	383	2	form	form	NOUN
admet-661	383	3	screening	screening	NOUN
admet-661	383	4	--	--	PUNCT
admet-661	383	5	a	a	DET
admet-661	383	6	review	review	NOUN
admet-661	383	7	.	.	PUNCT
admet-661	384	1	european	european	PROPN
admet-661	384	2	journal	journal	PROPN
admet-661	384	3	of	of	ADP
admet-661	384	4	pharmaceutics	pharmaceutic	NOUN
admet-661	384	5	and	and	CCONJ
admet-661	384	6	biopharmaceutics	biopharmaceutic	NOUN
admet-661	384	7	71	71	NUM
admet-661	384	8	(	(	PUNCT
admet-661	384	9	2009	2009	NUM
admet-661	384	10	)	)	PUNCT
admet-661	384	11	23	23	NUM
admet-661	384	12	-	-	SYM
admet-661	384	13	37	37	NUM
admet-661	384	14	.	.	PUNCT
admet-661	385	1	[	[	X
admet-661	385	2	2	2	X
admet-661	385	3	]	]	PUNCT
admet-661	385	4	p.	p.	NOUN
admet-661	385	5	vishweshwar	vishweshwar	NOUN
admet-661	385	6	,	,	PUNCT
admet-661	385	7	j.a	j.a	PROPN
admet-661	385	8	.	.	PROPN
admet-661	385	9	mcmahon	mcmahon	PROPN
admet-661	385	10	,	,	PUNCT
admet-661	385	11	j.a	j.a	PROPN
admet-661	385	12	.	.	PROPN
admet-661	385	13	bis	bis	PROPN
admet-661	385	14	,	,	PUNCT
admet-661	385	15	m.j	m.j	PROPN
admet-661	385	16	.	.	PROPN
admet-661	385	17	zaworotko	zaworotko	PROPN
admet-661	385	18	.	.	PUNCT
admet-661	386	1	pharmaceutical	pharmaceutical	PROPN
admet-661	386	2	co	co	NOUN
admet-661	386	3	-	-	NOUN
admet-661	387	1	crystals	crystal	NOUN
admet-661	387	2	.	.	PUNCT
admet-661	388	1	journal	journal	PROPN
admet-661	388	2	of	of	ADP
admet-661	388	3	pharmaceutical	pharmaceutical	PROPN
admet-661	388	4	sciences	science	NOUN
admet-661	388	5	95	95	NUM
admet-661	388	6	(	(	PUNCT
admet-661	388	7	2006	2006	NUM
admet-661	388	8	)	)	PUNCT
admet-661	388	9	499	499	NUM
admet-661	388	10	-	-	SYM
admet-661	388	11	516	516	NUM
admet-661	388	12	.	.	PUNCT
admet-661	389	1	[	[	X
admet-661	389	2	3	3	X
admet-661	389	3	]	]	X
admet-661	389	4	n.	n.	NOUN
admet-661	389	5	schultheiss	schultheiss	PROPN
admet-661	389	6	,	,	PUNCT
admet-661	389	7	a.	a.	PROPN
admet-661	389	8	newman	newman	PROPN
admet-661	389	9	.	.	PUNCT
admet-661	390	1	pharmaceutical	pharmaceutical	PROPN
admet-661	390	2	cocrystals	cocrystal	NOUN
admet-661	390	3	and	and	CCONJ
admet-661	390	4	their	their	PRON
admet-661	390	5	physicochemical	physicochemical	ADJ
admet-661	390	6	properties	property	NOUN
admet-661	390	7	.	.	PUNCT
admet-661	391	1	crystal	crystal	NOUN
admet-661	391	2	growth	growth	PROPN
admet-661	391	3	&	&	CCONJ
admet-661	391	4	design	design	PROPN
admet-661	391	5	9	9	NUM
admet-661	391	6	(	(	PUNCT
admet-661	391	7	2009	2009	NUM
admet-661	391	8	)	)	PUNCT
admet-661	391	9	2950	2950	NUM
admet-661	391	10	-	-	SYM
admet-661	391	11	2967	2967	NUM
admet-661	391	12	.	.	PUNCT
admet-661	392	1	admet	admet	PROPN
admet-661	392	2	&	&	CCONJ
admet-661	392	3	dmpk	dmpk	PROPN
admet-661	392	4	7(2	7(2	NUM
admet-661	392	5	)	)	PUNCT
admet-661	392	6	(	(	PUNCT
admet-661	392	7	2019	2019	NUM
admet-661	392	8	)	)	PUNCT
admet-661	392	9	106	106	NUM
admet-661	392	10	-	-	SYM
admet-661	392	11	130	130	NUM
admet-661	392	12	solubility	solubility	NOUN
admet-661	392	13	and	and	CCONJ
admet-661	392	14	dissolution	dissolution	NOUN
admet-661	392	15	of	of	ADP
admet-661	392	16	cocrystals	cocrystal	NOUN
admet-661	392	17	doi	doi	NOUN
admet-661	392	18	:	:	PUNCT
admet-661	392	19	10.5599	10.5599	NUM
admet-661	392	20	/	/	SYM
admet-661	392	21	admet.661	admet.661	PROPN
admet-661	392	22	127	127	NUM
admet-661	392	23	[	[	X
admet-661	392	24	4	4	NUM
admet-661	392	25	]	]	PUNCT
admet-661	392	26	p.	p.	NOUN
admet-661	393	1	cerreia	cerreia	PROPN
admet-661	394	1	vioglio	vioglio	PROPN
admet-661	394	2	,	,	PUNCT
admet-661	394	3	m.r	m.r	PROPN
admet-661	394	4	.	.	PROPN
admet-661	394	5	chierotti	chierotti	PROPN
admet-661	394	6	,	,	PUNCT
admet-661	394	7	r.	r.	PROPN
admet-661	394	8	gobetto	gobetto	PROPN
admet-661	394	9	.	.	PUNCT
admet-661	395	1	pharmaceutical	pharmaceutical	ADJ
admet-661	395	2	aspects	aspect	NOUN
admet-661	395	3	of	of	ADP
admet-661	395	4	salt	salt	NOUN
admet-661	395	5	and	and	CCONJ
admet-661	395	6	cocrystal	cocrystal	ADJ
admet-661	395	7	forms	form	NOUN
admet-661	395	8	of	of	ADP
admet-661	395	9	apis	apis	NOUN
admet-661	395	10	and	and	CCONJ
admet-661	395	11	characterization	characterization	NOUN
admet-661	395	12	challenges	challenge	NOUN
admet-661	395	13	.	.	PUNCT
admet-661	396	1	advanced	advanced	ADJ
admet-661	396	2	drug	drug	NOUN
admet-661	396	3	delivery	delivery	NOUN
admet-661	396	4	reviews	review	VERB
admet-661	396	5	117	117	NUM
admet-661	396	6	(	(	PUNCT
admet-661	396	7	2017	2017	NUM
admet-661	396	8	)	)	PUNCT
admet-661	396	9	86	86	NUM
admet-661	396	10	-	-	SYM
admet-661	396	11	110	110	NUM
admet-661	396	12	.	.	PUNCT
admet-661	397	1	[	[	X
admet-661	397	2	5	5	X
admet-661	397	3	]	]	X
admet-661	397	4	d.	d.	PROPN
admet-661	397	5	douroumis	douroumis	PROPN
admet-661	397	6	,	,	PUNCT
admet-661	397	7	s.a	s.a	PROPN
admet-661	397	8	.	.	PROPN
admet-661	397	9	ross	ross	PROPN
admet-661	397	10	,	,	PUNCT
admet-661	397	11	a.	a.	PROPN
admet-661	397	12	nokhodchi	nokhodchi	PROPN
admet-661	397	13	.	.	PUNCT
admet-661	398	1	advanced	advanced	ADJ
admet-661	398	2	methodologies	methodology	NOUN
admet-661	398	3	for	for	ADP
admet-661	398	4	cocrystal	cocrystal	ADJ
admet-661	398	5	synthesis	synthesis	NOUN
admet-661	398	6	.	.	PUNCT
admet-661	399	1	advanced	advanced	ADJ
admet-661	399	2	drug	drug	NOUN
admet-661	399	3	delivery	delivery	NOUN
admet-661	399	4	reviews	review	VERB
admet-661	399	5	117	117	NUM
admet-661	399	6	(	(	PUNCT
admet-661	399	7	2017	2017	NUM
admet-661	399	8	)	)	PUNCT
admet-661	399	9	178	178	NUM
admet-661	399	10	-	-	SYM
admet-661	399	11	195	195	NUM
admet-661	399	12	.	.	PUNCT
admet-661	400	1	[	[	X
admet-661	400	2	6	6	NUM
admet-661	400	3	]	]	PUNCT
admet-661	400	4	fda	fda	PROPN
admet-661	400	5	:	:	PUNCT
admet-661	400	6	regulatory	regulatory	ADJ
admet-661	400	7	classification	classification	NOUN
admet-661	400	8	of	of	ADP
admet-661	400	9	pharmaceutical	pharmaceutical	NOUN
admet-661	400	10	co	co	NOUN
admet-661	400	11	-	-	NOUN
admet-661	400	12	crystals	crystal	NOUN
admet-661	400	13	guidance	guidance	NOUN
admet-661	400	14	for	for	ADP
admet-661	400	15	industry	industry	NOUN
admet-661	400	16	.	.	PUNCT
admet-661	401	1	https://www.fda.gov/downloads/drugs/guidances/ucm281764.pdf	https://www.fda.gov/downloads/drugs/guidances/ucm281764.pdf	PROPN
admet-661	401	2	.	.	PUNCT
admet-661	402	1	published	publish	VERB
admet-661	402	2	in	in	ADP
admet-661	402	3	february	february	PROPN
admet-661	402	4	2018	2018	NUM
admet-661	402	5	.	.	PUNCT
admet-661	403	1	last	last	ADJ
admet-661	403	2	accessed	access	VERB
admet-661	403	3	august	august	PROPN
admet-661	403	4	17	17	NUM
admet-661	403	5	,	,	PUNCT
admet-661	403	6	2018	2018	NUM
admet-661	403	7	.	.	PUNCT
admet-661	404	1	[	[	X
admet-661	404	2	7	7	X
admet-661	404	3	]	]	X
admet-661	404	4	s.	s.	PROPN
admet-661	404	5	aitipamula	aitipamula	PROPN
admet-661	404	6	,	,	PUNCT
admet-661	404	7	r.	r.	PROPN
admet-661	404	8	banerjee	banerjee	PROPN
admet-661	404	9	,	,	PUNCT
admet-661	404	10	a.k	a.k	PROPN
admet-661	404	11	.	.	PROPN
admet-661	404	12	bansal	bansal	PROPN
admet-661	404	13	,	,	PUNCT
admet-661	404	14	k.	k.	PROPN
admet-661	404	15	biradha	biradha	PROPN
admet-661	404	16	,	,	PUNCT
admet-661	404	17	m.l	m.l	PROPN
admet-661	404	18	.	.	PROPN
admet-661	404	19	cheney	cheney	PROPN
admet-661	404	20	,	,	PUNCT
admet-661	404	21	a.r	a.r	PROPN
admet-661	404	22	.	.	PROPN
admet-661	404	23	choudhury	choudhury	PROPN
admet-661	404	24	,	,	PUNCT
admet-661	404	25	g.r	g.r	PROPN
admet-661	404	26	.	.	PROPN
admet-661	405	1	desiraju	desiraju	PROPN
admet-661	405	2	,	,	PUNCT
admet-661	405	3	a.g	a.g	PROPN
admet-661	405	4	.	.	PROPN
admet-661	405	5	dikundwar	dikundwar	PROPN
admet-661	405	6	,	,	PUNCT
admet-661	405	7	r.	r.	PROPN
admet-661	405	8	dubey	dubey	PROPN
admet-661	405	9	,	,	PUNCT
admet-661	405	10	n.	n.	NOUN
admet-661	405	11	duggirala	duggirala	PROPN
admet-661	405	12	,	,	PUNCT
admet-661	405	13	p.p	p.p	PROPN
admet-661	405	14	.	.	PROPN
admet-661	405	15	ghogale	ghogale	PROPN
admet-661	405	16	,	,	PUNCT
admet-661	405	17	s.	s.	PROPN
admet-661	405	18	ghosh	ghosh	PROPN
admet-661	405	19	,	,	PUNCT
admet-661	405	20	p.k	p.k	PROPN
admet-661	405	21	.	.	PROPN
admet-661	405	22	goswami	goswami	PROPN
admet-661	405	23	,	,	PUNCT
admet-661	405	24	n.r	n.r	PROPN
admet-661	405	25	.	.	PROPN
admet-661	405	26	goud	goud	PROPN
admet-661	405	27	,	,	PUNCT
admet-661	405	28	r.r.k.r	r.r.k.r	PROPN
admet-661	405	29	.	.	PROPN
admet-661	405	30	jetti	jetti	PROPN
admet-661	405	31	,	,	PUNCT
admet-661	405	32	p.	p.	NOUN
admet-661	405	33	karpinski	karpinski	PROPN
admet-661	405	34	,	,	PUNCT
admet-661	405	35	p.	p.	PROPN
admet-661	405	36	kaushik	kaushik	PROPN
admet-661	405	37	,	,	PUNCT
admet-661	405	38	d.	d.	PROPN
admet-661	405	39	kumar	kumar	PROPN
admet-661	405	40	,	,	PUNCT
admet-661	405	41	v.	v.	PROPN
admet-661	405	42	kumar	kumar	PROPN
admet-661	405	43	,	,	PUNCT
admet-661	405	44	b.	b.	PROPN
admet-661	405	45	moulton	moulton	PROPN
admet-661	405	46	,	,	PUNCT
admet-661	405	47	a.	a.	NOUN
admet-661	405	48	mukherjee	mukherjee	PROPN
admet-661	405	49	,	,	PUNCT
admet-661	405	50	g.	g.	PROPN
admet-661	405	51	mukherjee	mukherjee	PROPN
admet-661	405	52	,	,	PUNCT
admet-661	405	53	a.s	a.s	PROPN
admet-661	405	54	.	.	PROPN
admet-661	405	55	myerson	myerson	PROPN
admet-661	405	56	,	,	PUNCT
admet-661	405	57	v.	v.	PROPN
admet-661	405	58	puri	puri	PROPN
admet-661	405	59	,	,	PUNCT
admet-661	405	60	a.	a.	NOUN
admet-661	405	61	ramanan	ramanan	PROPN
admet-661	405	62	,	,	PUNCT
admet-661	405	63	t.	t.	PROPN
admet-661	405	64	rajamannar	rajamannar	PROPN
admet-661	405	65	,	,	PUNCT
admet-661	405	66	c.m	c.m	PROPN
admet-661	405	67	.	.	PROPN
admet-661	405	68	reddy	reddy	PROPN
admet-661	405	69	,	,	PUNCT
admet-661	405	70	n.	n.	PROPN
admet-661	405	71	rodriguez	rodriguez	PROPN
admet-661	405	72	-	-	PUNCT
admet-661	405	73	hornedo	hornedo	PROPN
admet-661	405	74	,	,	PUNCT
admet-661	405	75	r.d	r.d	PROPN
admet-661	405	76	.	.	PROPN
admet-661	405	77	rogers	rogers	PROPN
admet-661	405	78	,	,	PUNCT
admet-661	405	79	t.n.g	t.n.g	NOUN
admet-661	405	80	.	.	PUNCT
admet-661	406	1	row	row	NOUN
admet-661	406	2	,	,	PUNCT
admet-661	406	3	p.	p.	PROPN
admet-661	406	4	sanphui	sanphui	PROPN
admet-661	406	5	,	,	PUNCT
admet-661	406	6	n.	n.	PROPN
admet-661	406	7	shan	shan	PROPN
admet-661	406	8	,	,	PUNCT
admet-661	406	9	g.	g.	PROPN
admet-661	406	10	shete	shete	PROPN
admet-661	406	11	,	,	PUNCT
admet-661	406	12	a.	a.	PROPN
admet-661	406	13	singh	singh	PROPN
admet-661	406	14	,	,	PUNCT
admet-661	406	15	c.c	c.c	PROPN
admet-661	406	16	.	.	PROPN
admet-661	406	17	sun	sun	PROPN
admet-661	406	18	,	,	PUNCT
admet-661	406	19	j.a	j.a	PROPN
admet-661	406	20	.	.	PROPN
admet-661	406	21	swift	swift	PROPN
admet-661	406	22	,	,	PUNCT
admet-661	406	23	r.	r.	PROPN
admet-661	406	24	thaimattam	thaimattam	PROPN
admet-661	406	25	,	,	PUNCT
admet-661	406	26	t.s	t.s	PROPN
admet-661	406	27	.	.	PROPN
admet-661	406	28	thakur	thakur	PROPN
admet-661	406	29	,	,	PUNCT
admet-661	406	30	r.	r.	PROPN
admet-661	406	31	kumar	kumar	PROPN
admet-661	406	32	thaper	thaper	PROPN
admet-661	406	33	,	,	PUNCT
admet-661	406	34	s.p	s.p	PROPN
admet-661	406	35	.	.	PROPN
admet-661	406	36	thomas	thomas	PROPN
admet-661	406	37	,	,	PUNCT
admet-661	406	38	s.	s.	PROPN
admet-661	406	39	tothadi	tothadi	PROPN
admet-661	406	40	,	,	PUNCT
admet-661	406	41	v.r	v.r	PROPN
admet-661	406	42	.	.	PROPN
admet-661	406	43	vangala	vangala	PROPN
admet-661	406	44	,	,	PUNCT
admet-661	406	45	n.	n.	NOUN
admet-661	406	46	variankaval	variankaval	NOUN
admet-661	406	47	,	,	PUNCT
admet-661	406	48	p.	p.	NOUN
admet-661	406	49	vishweshwar	vishweshwar	PROPN
admet-661	406	50	,	,	PUNCT
admet-661	406	51	d.r	d.r	PROPN
admet-661	406	52	.	.	PROPN
admet-661	406	53	weyna	weyna	PROPN
admet-661	406	54	,	,	PUNCT
admet-661	406	55	m.j	m.j	PROPN
admet-661	406	56	.	.	PROPN
admet-661	406	57	zaworotko	zaworotko	PROPN
admet-661	406	58	.	.	PUNCT
admet-661	407	1	polymorphs	polymorph	NOUN
admet-661	407	2	,	,	PUNCT
admet-661	407	3	salts	salt	NOUN
admet-661	407	4	,	,	PUNCT
admet-661	407	5	and	and	CCONJ
admet-661	407	6	cocrystals	cocrystal	NOUN
admet-661	407	7	:	:	PUNCT
admet-661	407	8	what	what	PRON
admet-661	407	9	’s	’	VERB
admet-661	407	10	in	in	ADP
admet-661	407	11	a	a	DET
admet-661	407	12	name	name	NOUN
admet-661	407	13	?	?	PUNCT
admet-661	408	1	crystal	crystal	NOUN
admet-661	408	2	growth	growth	PROPN
admet-661	408	3	&	&	CCONJ
admet-661	408	4	design	design	PROPN
admet-661	408	5	12	12	NUM
admet-661	408	6	(	(	PUNCT
admet-661	408	7	2012	2012	NUM
admet-661	408	8	)	)	PUNCT
admet-661	408	9	2147	2147	NUM
admet-661	408	10	-	-	SYM
admet-661	408	11	2152	2152	NUM
admet-661	408	12	.	.	PUNCT
admet-661	409	1	[	[	X
admet-661	409	2	8	8	NUM
admet-661	409	3	]	]	X
admet-661	409	4	d.j	d.j	PROPN
admet-661	409	5	.	.	PROPN
admet-661	409	6	berry	berry	PROPN
admet-661	409	7	,	,	PUNCT
admet-661	409	8	j.w	j.w	PROPN
admet-661	409	9	.	.	PROPN
admet-661	409	10	steed	steed	PROPN
admet-661	409	11	.	.	PUNCT
admet-661	410	1	pharmaceutical	pharmaceutical	ADJ
admet-661	410	2	cocrystals	cocrystal	NOUN
admet-661	410	3	,	,	PUNCT
admet-661	410	4	salts	salt	NOUN
admet-661	410	5	and	and	CCONJ
admet-661	410	6	multicomponent	multicomponent	NOUN
admet-661	410	7	systems	system	NOUN
admet-661	410	8	;	;	PUNCT
admet-661	410	9	intermolecular	intermolecular	ADJ
admet-661	410	10	interactions	interaction	NOUN
admet-661	410	11	and	and	CCONJ
admet-661	410	12	property	property	NOUN
admet-661	410	13	based	base	VERB
admet-661	410	14	design	design	NOUN
admet-661	410	15	.	.	PUNCT
admet-661	411	1	advanced	advanced	ADJ
admet-661	411	2	drug	drug	NOUN
admet-661	411	3	delivery	delivery	NOUN
admet-661	411	4	reviews	review	VERB
admet-661	411	5	117	117	NUM
admet-661	411	6	(	(	PUNCT
admet-661	411	7	2017	2017	NUM
admet-661	411	8	)	)	PUNCT
admet-661	411	9	3	3	NUM
admet-661	411	10	-	-	SYM
admet-661	411	11	24	24	NUM
admet-661	411	12	.	.	PUNCT
admet-661	412	1	[	[	X
admet-661	412	2	9	9	NUM
admet-661	412	3	]	]	X
admet-661	412	4	d.p	d.p	PROPN
admet-661	412	5	.	.	PROPN
admet-661	412	6	kale	kale	PROPN
admet-661	412	7	,	,	PUNCT
admet-661	412	8	s.s	s.s	PROPN
admet-661	412	9	.	.	PROPN
admet-661	412	10	zode	zode	PROPN
admet-661	412	11	,	,	PUNCT
admet-661	412	12	a.k	a.k	PROPN
admet-661	412	13	.	.	PROPN
admet-661	412	14	bansal	bansal	NOUN
admet-661	412	15	.	.	PUNCT
admet-661	413	1	challenges	challenge	NOUN
admet-661	413	2	in	in	ADP
admet-661	413	3	translational	translational	ADJ
admet-661	413	4	development	development	NOUN
admet-661	413	5	of	of	ADP
admet-661	413	6	pharmaceutical	pharmaceutical	ADJ
admet-661	413	7	cocrystals	cocrystal	NOUN
admet-661	413	8	.	.	PUNCT
admet-661	414	1	journal	journal	NOUN
admet-661	414	2	of	of	ADP
admet-661	414	3	pharmaceutical	pharmaceutical	PROPN
admet-661	414	4	sciences	science	NOUN
admet-661	414	5	106	106	NUM
admet-661	414	6	(	(	PUNCT
admet-661	414	7	2017	2017	NUM
admet-661	414	8	)	)	PUNCT
admet-661	414	9	457	457	NUM
admet-661	414	10	-	-	SYM
admet-661	414	11	470	470	NUM
admet-661	414	12	.	.	PUNCT
admet-661	415	1	[	[	X
admet-661	415	2	10	10	NUM
admet-661	415	3	]	]	X
admet-661	415	4	r.m	r.m	PROPN
admet-661	415	5	.	.	PROPN
admet-661	415	6	poole	poole	PROPN
admet-661	415	7	,	,	PUNCT
admet-661	415	8	r.t	r.t	PROPN
admet-661	415	9	.	.	PROPN
admet-661	415	10	dungo	dungo	PROPN
admet-661	415	11	.	.	PUNCT
admet-661	416	1	ipragliflozin	ipragliflozin	PROPN
admet-661	416	2	:	:	PUNCT
admet-661	416	3	first	first	ADJ
admet-661	416	4	global	global	ADJ
admet-661	416	5	approval	approval	NOUN
admet-661	416	6	.	.	PUNCT
admet-661	417	1	drugs	drug	NOUN
admet-661	417	2	74	74	NUM
admet-661	417	3	(	(	PUNCT
admet-661	417	4	2014	2014	NUM
admet-661	417	5	)	)	PUNCT
admet-661	417	6	611	611	NUM
admet-661	417	7	-	-	SYM
admet-661	417	8	617	617	NUM
admet-661	417	9	.	.	PUNCT
admet-661	418	1	[	[	X
admet-661	418	2	11	11	NUM
admet-661	418	3	]	]	PUNCT
admet-661	418	4	a.	a.	NOUN
admet-661	418	5	kumar	kumar	PROPN
admet-661	418	6	,	,	PUNCT
admet-661	418	7	s.	s.	PROPN
admet-661	418	8	kumar	kumar	PROPN
admet-661	418	9	,	,	PUNCT
admet-661	418	10	a.	a.	PROPN
admet-661	418	11	nanda	nanda	PROPN
admet-661	418	12	.	.	PUNCT
admet-661	419	1	a	a	DET
admet-661	419	2	review	review	NOUN
admet-661	419	3	about	about	ADP
admet-661	419	4	regulatory	regulatory	ADJ
admet-661	419	5	status	status	NOUN
admet-661	419	6	and	and	CCONJ
admet-661	419	7	recent	recent	ADJ
admet-661	419	8	patents	patent	NOUN
admet-661	419	9	of	of	ADP
admet-661	419	10	pharmaceutical	pharmaceutical	NOUN
admet-661	419	11	co	co	NOUN
admet-661	419	12	-	-	NOUN
admet-661	419	13	crystals	crystal	NOUN
admet-661	419	14	.	.	PUNCT
admet-661	420	1	advanced	advanced	ADJ
admet-661	420	2	pharmaceutical	pharmaceutical	ADJ
admet-661	420	3	bulletin	bulletin	NOUN
admet-661	420	4	8	8	NUM
admet-661	420	5	(	(	PUNCT
admet-661	420	6	2018	2018	NUM
admet-661	420	7	)	)	PUNCT
admet-661	420	8	355	355	NUM
admet-661	420	9	-	-	SYM
admet-661	420	10	363	363	NUM
admet-661	420	11	.	.	PUNCT
admet-661	421	1	[	[	X
admet-661	421	2	12	12	NUM
admet-661	421	3	]	]	PUNCT
admet-661	421	4	l.	l.	PROPN
admet-661	421	5	feng	feng	PROPN
admet-661	421	6	,	,	PUNCT
admet-661	421	7	p.h	p.h	PROPN
admet-661	421	8	.	.	PROPN
admet-661	421	9	karpinski	karpinski	PROPN
admet-661	421	10	,	,	PUNCT
admet-661	421	11	p.	p.	NOUN
admet-661	421	12	sutton	sutton	PROPN
admet-661	421	13	,	,	PUNCT
admet-661	421	14	y.	y.	PROPN
admet-661	421	15	liu	liu	PROPN
admet-661	421	16	,	,	PUNCT
admet-661	421	17	d.f	d.f	PROPN
admet-661	421	18	.	.	PROPN
admet-661	421	19	hook	hook	NOUN
admet-661	421	20	,	,	PUNCT
admet-661	421	21	b.	b.	PROPN
admet-661	421	22	hu	hu	PROPN
admet-661	421	23	,	,	PUNCT
admet-661	421	24	t.j	t.j	PROPN
admet-661	421	25	.	.	PROPN
admet-661	421	26	blacklock	blacklock	NOUN
admet-661	421	27	,	,	PUNCT
admet-661	421	28	p.	p.	PROPN
admet-661	421	29	e.	e.	PROPN
admet-661	421	30	fanwick	fanwick	PROPN
admet-661	421	31	,	,	PUNCT
admet-661	421	32	m.	m.	NOUN
admet-661	421	33	prashad	prashad	VERB
admet-661	421	34	,	,	PUNCT
admet-661	421	35	s.	s.	PROPN
admet-661	421	36	godtfredsen	godtfredsen	PROPN
admet-661	421	37	,	,	PUNCT
admet-661	421	38	c.	c.	PROPN
admet-661	421	39	ziltener	ziltener	NOUN
admet-661	421	40	.	.	PUNCT
admet-661	422	1	lcz696	lcz696	NOUN
admet-661	422	2	:	:	PUNCT
admet-661	422	3	a	a	DET
admet-661	422	4	dual	dual	ADV
admet-661	422	5	-	-	PUNCT
admet-661	422	6	acting	act	VERB
admet-661	422	7	sodium	sodium	NOUN
admet-661	422	8	supramolecular	supramolecular	ADJ
admet-661	422	9	complex	complex	NOUN
admet-661	422	10	.	.	PUNCT
admet-661	423	1	tetrahedron	tetrahedron	NOUN
admet-661	423	2	letters	letter	NOUN
admet-661	423	3	53	53	NUM
admet-661	423	4	(	(	PUNCT
admet-661	423	5	2012	2012	NUM
admet-661	423	6	)	)	PUNCT
admet-661	423	7	275	275	NUM
admet-661	423	8	-	-	SYM
admet-661	423	9	276	276	NUM
admet-661	423	10	.	.	PUNCT
admet-661	424	1	[	[	X
admet-661	424	2	13	13	NUM
admet-661	424	3	]	]	PUNCT
admet-661	424	4	assessment	assessment	NOUN
admet-661	424	5	report	report	NOUN
admet-661	424	6	:	:	PUNCT
admet-661	424	7	steglatro	steglatro	NOUN
admet-661	424	8	,	,	PUNCT
admet-661	424	9	european	european	ADJ
admet-661	424	10	medicines	medicine	NOUN
admet-661	424	11	agency	agency	NOUN
admet-661	424	12	,	,	PUNCT
admet-661	424	13	25	25	NUM
admet-661	424	14	january	january	PROPN
admet-661	424	15	,	,	PUNCT
admet-661	424	16	2018	2018	NUM
admet-661	424	17	.	.	PUNCT
admet-661	425	1	https://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessmentreport_en.pdf	https://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessmentreport_en.pdf	PROPN
admet-661	425	2	.	.	PUNCT
admet-661	426	1	last	last	ADJ
admet-661	426	2	accessed	access	VERB
admet-661	426	3	january	january	PROPN
admet-661	426	4	12	12	NUM
admet-661	426	5	,	,	PUNCT
admet-661	426	6	2019	2019	NUM
admet-661	426	7	.	.	PUNCT
admet-661	427	1	[	[	X
admet-661	427	2	14	14	NUM
admet-661	427	3	]	]	X
admet-661	427	4	r.	r.	PROPN
admet-661	427	5	thakuria	thakuria	PROPN
admet-661	427	6	,	,	PUNCT
admet-661	427	7	a.	a.	PROPN
admet-661	427	8	delori	delori	PROPN
admet-661	427	9	,	,	PUNCT
admet-661	427	10	w.	w.	PROPN
admet-661	427	11	jones	jones	PROPN
admet-661	427	12	,	,	PUNCT
admet-661	427	13	m.p	m.p	PROPN
admet-661	427	14	.	.	PROPN
admet-661	427	15	lipert	lipert	PROPN
admet-661	427	16	,	,	PUNCT
admet-661	427	17	l.	l.	PROPN
admet-661	427	18	roy	roy	PROPN
admet-661	427	19	,	,	PUNCT
admet-661	427	20	n.	n.	PROPN
admet-661	427	21	rodríguez	rodríguez	PROPN
admet-661	427	22	-	-	PUNCT
admet-661	427	23	hornedo	hornedo	NOUN
admet-661	427	24	.	.	PUNCT
admet-661	427	25	pharmaceutical	pharmaceutical	ADJ
admet-661	427	26	cocrystals	cocrystal	NOUN
admet-661	427	27	and	and	CCONJ
admet-661	427	28	poorly	poorly	ADV
admet-661	427	29	soluble	soluble	ADJ
admet-661	427	30	drugs	drug	NOUN
admet-661	427	31	.	.	PUNCT
admet-661	428	1	international	international	ADJ
admet-661	428	2	journal	journal	PROPN
admet-661	428	3	of	of	ADP
admet-661	428	4	pharmaceutics	pharmaceutic	NOUN
admet-661	428	5	453	453	NUM
admet-661	428	6	(	(	PUNCT
admet-661	428	7	2013	2013	NUM
admet-661	428	8	)	)	PUNCT
admet-661	428	9	101	101	NUM
admet-661	428	10	-	-	SYM
admet-661	428	11	125	125	NUM
admet-661	428	12	.	.	PUNCT
admet-661	429	1	[	[	X
admet-661	429	2	15	15	NUM
admet-661	429	3	]	]	X
admet-661	429	4	d.j	d.j	PROPN
admet-661	429	5	.	.	PROPN
admet-661	429	6	good	good	PROPN
admet-661	429	7	,	,	PUNCT
admet-661	429	8	n.	n.	PROPN
admet-661	429	9	rodríguez	rodríguez	PROPN
admet-661	429	10	-	-	PUNCT
admet-661	429	11	hornedo	hornedo	NOUN
admet-661	429	12	.	.	PUNCT
admet-661	430	1	solubility	solubility	NOUN
admet-661	430	2	advantage	advantage	NOUN
admet-661	430	3	of	of	ADP
admet-661	430	4	pharmaceutical	pharmaceutical	ADJ
admet-661	430	5	cocrystals	cocrystal	NOUN
admet-661	430	6	.	.	PUNCT
admet-661	431	1	crystal	crystal	NOUN
admet-661	431	2	growth	growth	PROPN
admet-661	431	3	&	&	CCONJ
admet-661	431	4	design	design	PROPN
admet-661	431	5	9	9	NUM
admet-661	431	6	(	(	PUNCT
admet-661	431	7	2009	2009	NUM
admet-661	431	8	)	)	PUNCT
admet-661	431	9	2252	2252	NUM
admet-661	431	10	-	-	SYM
admet-661	431	11	2264	2264	NUM
admet-661	431	12	.	.	PUNCT
admet-661	432	1	[	[	X
admet-661	432	2	16	16	NUM
admet-661	432	3	]	]	PUNCT
admet-661	432	4	a.	a.	PROPN
admet-661	432	5	kozak	kozak	PROPN
admet-661	432	6	,	,	PUNCT
admet-661	432	7	p.h	p.h	PROPN
admet-661	432	8	.	.	PROPN
admet-661	432	9	marek	marek	PROPN
admet-661	432	10	,	,	PUNCT
admet-661	432	11	e.	e.	PROPN
admet-661	432	12	pindelska	pindelska	PROPN
admet-661	432	13	.	.	PUNCT
admet-661	433	1	structural	structural	ADJ
admet-661	433	2	characterization	characterization	NOUN
admet-661	433	3	and	and	CCONJ
admet-661	433	4	pharmaceutical	pharmaceutical	NOUN
admet-661	433	5	properties	property	NOUN
admet-661	433	6	of	of	ADP
admet-661	433	7	three	three	NUM
admet-661	433	8	novel	novel	ADJ
admet-661	433	9	cocrystals	cocrystal	NOUN
admet-661	433	10	of	of	ADP
admet-661	433	11	ethenzamide	ethenzamide	NOUN
admet-661	433	12	with	with	ADP
admet-661	433	13	aliphatic	aliphatic	ADJ
admet-661	433	14	dicarboxylic	dicarboxylic	ADJ
admet-661	433	15	acids	acid	NOUN
admet-661	433	16	.	.	PUNCT
admet-661	434	1	journal	journal	NOUN
admet-661	434	2	of	of	ADP
admet-661	434	3	pharmaceutical	pharmaceutical	PROPN
admet-661	434	4	sciences	science	NOUN
admet-661	434	5	108	108	NUM
admet-661	434	6	(	(	PUNCT
admet-661	434	7	2019	2019	NUM
admet-661	434	8	)	)	PUNCT
admet-661	434	9	1476	1476	NUM
admet-661	434	10	-	-	SYM
admet-661	434	11	1485	1485	NUM
admet-661	434	12	.	.	PUNCT
admet-661	435	1	(	(	PUNCT
admet-661	435	2	https://doi.org/10.1016/j.xphs.2018.10.060	https://doi.org/10.1016/j.xphs.2018.10.060	NOUN
admet-661	435	3	)	)	PUNCT
admet-661	436	1	[	[	X
admet-661	436	2	17	17	NUM
admet-661	436	3	]	]	X
admet-661	436	4	m.k	m.k	PROPN
admet-661	436	5	.	.	PROPN
admet-661	436	6	stanton	stanton	PROPN
admet-661	436	7	,	,	PUNCT
admet-661	436	8	a.	a.	NOUN
admet-661	436	9	bak	bak	PROPN
admet-661	436	10	.	.	PUNCT
admet-661	437	1	physicochemical	physicochemical	ADJ
admet-661	437	2	properties	property	NOUN
admet-661	437	3	of	of	ADP
admet-661	437	4	pharmaceutical	pharmaceutical	NOUN
admet-661	437	5	co	co	NOUN
admet-661	437	6	-	-	NOUN
admet-661	437	7	crystals	crystal	NOUN
admet-661	437	8	:	:	PUNCT
admet-661	437	9	a	a	DET
admet-661	437	10	case	case	NOUN
admet-661	437	11	study	study	NOUN
admet-661	437	12	of	of	ADP
admet-661	437	13	ten	ten	NUM
admet-661	437	14	amg	amg	NOUN
admet-661	437	15	517	517	NUM
admet-661	437	16	co	co	NOUN
admet-661	437	17	-	-	NOUN
admet-661	437	18	crystals	crystal	NOUN
admet-661	437	19	.	.	PUNCT
admet-661	438	1	crystal	crystal	NOUN
admet-661	438	2	growth	growth	PROPN
admet-661	438	3	&	&	CCONJ
admet-661	438	4	design	design	PROPN
admet-661	438	5	8	8	NUM
admet-661	438	6	(	(	PUNCT
admet-661	438	7	2008	2008	NUM
admet-661	438	8	)	)	PUNCT
admet-661	438	9	3856	3856	NUM
admet-661	438	10	-	-	SYM
admet-661	438	11	3862	3862	NUM
admet-661	438	12	.	.	PUNCT
admet-661	439	1	[	[	X
admet-661	439	2	18	18	NUM
admet-661	439	3	]	]	X
admet-661	439	4	r.	r.	PROPN
admet-661	439	5	chadha	chadha	PROPN
admet-661	439	6	,	,	PUNCT
admet-661	439	7	a.	a.	PROPN
admet-661	439	8	saini	saini	PROPN
admet-661	439	9	,	,	PUNCT
admet-661	439	10	s.	s.	PROPN
admet-661	439	11	khullar	khullar	PROPN
admet-661	439	12	,	,	PUNCT
admet-661	439	13	d.s	d.s	PROPN
admet-661	439	14	.	.	PROPN
admet-661	439	15	jain	jain	PROPN
admet-661	439	16	,	,	PUNCT
admet-661	439	17	s.k	s.k	PROPN
admet-661	439	18	.	.	PROPN
admet-661	439	19	mandal	mandal	PROPN
admet-661	439	20	,	,	PUNCT
admet-661	439	21	t.n	t.n	PROPN
admet-661	439	22	.	.	PROPN
admet-661	439	23	guru	guru	NOUN
admet-661	439	24	row	row	NOUN
admet-661	439	25	.	.	PUNCT
admet-661	440	1	crystal	crystal	NOUN
admet-661	440	2	structures	structure	NOUN
admet-661	440	3	and	and	CCONJ
admet-661	440	4	physicochemical	physicochemical	ADJ
admet-661	440	5	properties	property	NOUN
admet-661	440	6	of	of	ADP
admet-661	440	7	four	four	NUM
admet-661	440	8	new	new	ADJ
admet-661	440	9	lamotrigine	lamotrigine	ADJ
admet-661	440	10	multicomponent	multicomponent	NOUN
admet-661	440	11	forms	form	NOUN
admet-661	440	12	.	.	PUNCT
admet-661	441	1	crystal	crystal	NOUN
admet-661	441	2	growth	growth	PROPN
admet-661	441	3	&	&	CCONJ
admet-661	441	4	design	design	PROPN
admet-661	441	5	13	13	NUM
admet-661	441	6	(	(	PUNCT
admet-661	441	7	2013	2013	NUM
admet-661	441	8	)	)	PUNCT
admet-661	441	9	858	858	NUM
admet-661	441	10	-	-	SYM
admet-661	441	11	870	870	NUM
admet-661	441	12	.	.	PUNCT
admet-661	442	1	[	[	X
admet-661	442	2	19	19	NUM
admet-661	442	3	]	]	X
admet-661	442	4	y.	y.	PROPN
admet-661	442	5	gao	gao	PROPN
admet-661	442	6	,	,	PUNCT
admet-661	442	7	j.	j.	PROPN
admet-661	442	8	gao	gao	PROPN
admet-661	442	9	,	,	PUNCT
admet-661	442	10	z.	z.	PROPN
admet-661	442	11	liu	liu	PROPN
admet-661	442	12	,	,	PUNCT
admet-661	442	13	h.	h.	PROPN
admet-661	442	14	kan	kan	PROPN
admet-661	442	15	,	,	PUNCT
admet-661	442	16	h.	h.	PROPN
admet-661	442	17	zu	zu	PROPN
admet-661	442	18	,	,	PUNCT
admet-661	442	19	w.	w.	PROPN
admet-661	442	20	sun	sun	PROPN
admet-661	442	21	,	,	PUNCT
admet-661	442	22	j.	j.	PROPN
admet-661	442	23	zhang	zhang	PROPN
admet-661	442	24	,	,	PUNCT
admet-661	442	25	s.	s.	PROPN
admet-661	442	26	qian	qian	PROPN
admet-661	442	27	.	.	PUNCT
admet-661	443	1	coformer	coformer	PROPN
admet-661	443	2	selection	selection	NOUN
admet-661	443	3	based	base	VERB
admet-661	443	4	on	on	ADP
admet-661	443	5	degradation	degradation	NOUN
admet-661	443	6	pathway	pathway	NOUN
admet-661	443	7	of	of	ADP
admet-661	443	8	drugs	drug	NOUN
admet-661	443	9	:	:	PUNCT
admet-661	443	10	a	a	DET
admet-661	443	11	case	case	NOUN
admet-661	443	12	study	study	NOUN
admet-661	443	13	of	of	ADP
admet-661	443	14	adefovir	adefovir	PROPN
admet-661	443	15	dipivoxil	dipivoxil	ADJ
admet-661	443	16	-	-	PUNCT
admet-661	443	17	saccharin	saccharin	NOUN
admet-661	443	18	and	and	CCONJ
admet-661	443	19	adefovir	adefovir	NOUN
admet-661	443	20	dipivoxilnicotinamide	dipivoxilnicotinamide	ADJ
admet-661	443	21	cocrystals	cocrystal	NOUN
admet-661	443	22	.	.	PUNCT
admet-661	444	1	international	international	ADJ
admet-661	444	2	journal	journal	PROPN
admet-661	444	3	of	of	ADP
admet-661	444	4	pharmaceutics	pharmaceutic	NOUN
admet-661	444	5	438	438	NUM
admet-661	444	6	(	(	PUNCT
admet-661	444	7	2012	2012	NUM
admet-661	444	8	)	)	PUNCT
admet-661	444	9	327	327	NUM
admet-661	444	10	-	-	SYM
admet-661	444	11	335	335	NUM
admet-661	444	12	.	.	PUNCT
admet-661	445	1	[	[	X
admet-661	445	2	20	20	NUM
admet-661	445	3	]	]	X
admet-661	445	4	m.l	m.l	PROPN
admet-661	445	5	.	.	PROPN
admet-661	445	6	cheney	cheney	PROPN
admet-661	445	7	,	,	PUNCT
admet-661	445	8	n.	n.	PROPN
admet-661	445	9	shan	shan	PROPN
admet-661	445	10	,	,	PUNCT
admet-661	445	11	e.r	e.r	PROPN
admet-661	445	12	.	.	PROPN
admet-661	445	13	healey	healey	PROPN
admet-661	445	14	,	,	PUNCT
admet-661	445	15	m.	m.	NOUN
admet-661	445	16	hanna	hanna	PROPN
admet-661	445	17	,	,	PUNCT
admet-661	445	18	l.	l.	PROPN
admet-661	445	19	wojtas	wojtas	PROPN
admet-661	445	20	,	,	PUNCT
admet-661	445	21	m.j	m.j	PROPN
admet-661	445	22	.	.	PROPN
admet-661	445	23	zaworotko	zaworotko	PROPN
admet-661	445	24	,	,	PUNCT
admet-661	445	25	v.	v.	PROPN
admet-661	445	26	sava	sava	PROPN
admet-661	445	27	,	,	PUNCT
admet-661	445	28	s.	s.	PROPN
admet-661	445	29	song	song	PROPN
admet-661	445	30	,	,	PUNCT
admet-661	445	31	j.r	j.r	PROPN
admet-661	445	32	.	.	PROPN
admet-661	445	33	sanchez	sanchez	PROPN
admet-661	445	34	-	-	PUNCT
admet-661	445	35	ramos	ramos	PROPN
admet-661	445	36	.	.	PUNCT
admet-661	446	1	effects	effect	NOUN
admet-661	446	2	of	of	ADP
admet-661	446	3	crystal	crystal	NOUN
admet-661	446	4	form	form	NOUN
admet-661	446	5	on	on	ADP
admet-661	446	6	solubility	solubility	NOUN
admet-661	446	7	and	and	CCONJ
admet-661	446	8	pharmacokinetics	pharmacokinetic	NOUN
admet-661	446	9	:	:	PUNCT
admet-661	446	10	a	a	DET
admet-661	446	11	crystal	crystal	NOUN
admet-661	446	12	engineering	engineering	NOUN
admet-661	446	13	case	case	NOUN
admet-661	446	14	study	study	NOUN
admet-661	446	15	of	of	ADP
admet-661	446	16	lamotrigine	lamotrigine	PROPN
admet-661	446	17	.	.	PUNCT
admet-661	447	1	crystal	crystal	NOUN
admet-661	447	2	growth	growth	PROPN
admet-661	447	3	&	&	CCONJ
admet-661	447	4	design	design	PROPN
admet-661	447	5	10	10	NUM
admet-661	447	6	(	(	PUNCT
admet-661	447	7	2010	2010	NUM
admet-661	447	8	)	)	PUNCT
admet-661	447	9	394	394	NUM
admet-661	447	10	-	-	SYM
admet-661	447	11	405	405	NUM
admet-661	447	12	.	.	PUNCT
admet-661	448	1	[	[	X
admet-661	448	2	21	21	NUM
admet-661	448	3	]	]	X
admet-661	448	4	c.	c.	NOUN
admet-661	448	5	ràfols	ràfols	PROPN
admet-661	448	6	,	,	PUNCT
admet-661	448	7	h.	h.	PROPN
admet-661	448	8	fael	fael	PROPN
admet-661	448	9	,	,	PUNCT
admet-661	448	10	e.	e.	PROPN
admet-661	448	11	fuguet	fuguet	PROPN
admet-661	448	12	,	,	PUNCT
admet-661	448	13	b.	b.	PROPN
admet-661	448	14	outhwaite	outhwaite	PROPN
admet-661	448	15	,	,	PUNCT
admet-661	448	16	s.	s.	PROPN
admet-661	448	17	lee	lee	PROPN
admet-661	448	18	,	,	PUNCT
admet-661	448	19	r.	r.	PROPN
admet-661	448	20	ruiz	ruiz	PROPN
admet-661	448	21	.	.	PUNCT
admet-661	449	1	dissolution	dissolution	NOUN
admet-661	449	2	rates	rate	NOUN
admet-661	449	3	of	of	ADP
admet-661	449	4	ciprofloxacin	ciprofloxacin	PROPN
admet-661	449	5	and	and	CCONJ
admet-661	449	6	its	its	PRON
admet-661	449	7	cocrystal	cocrystal	NOUN
admet-661	449	8	with	with	ADP
admet-661	449	9	resorcinol	resorcinol	NOUN
admet-661	449	10	.	.	PUNCT
admet-661	450	1	admet	admet	PROPN
admet-661	450	2	and	and	CCONJ
admet-661	450	3	dmpk	dmpk	VERB
admet-661	450	4	6	6	NUM
admet-661	450	5	(	(	PUNCT
admet-661	450	6	2018	2018	NUM
admet-661	450	7	)	)	PUNCT
admet-661	450	8	61	61	NUM
admet-661	450	9	-	-	SYM
admet-661	450	10	70	70	NUM
admet-661	450	11	.	.	PUNCT
admet-661	450	12	http://www.fda.gov/downloads/drugs/guidances/ucm281764.pdf	http://www.fda.gov/downloads/drugs/guidances/ucm281764.pdf	PROPN
admet-661	450	13	http://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessment-report_en.pdf	http://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessment-report_en.pdf	PROPN
admet-661	450	14	http://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessment-report_en.pdf	http://www.ema.europa.eu/documents/assessment-report/steglatro-epar-public-assessment-report_en.pdf	PROPN
admet-661	450	15	vasoya	vasoya	PROPN
admet-661	450	16	et	et	PROPN
admet-661	450	17	al	al	PROPN
admet-661	450	18	.	.	PROPN
admet-661	450	19	admet	admet	PROPN
admet-661	450	20	&	&	CCONJ
admet-661	450	21	dmpk	dmpk	PROPN
admet-661	450	22	7(2	7(2	NUM
admet-661	450	23	)	)	PUNCT
admet-661	450	24	(	(	PUNCT
admet-661	450	25	2019	2019	NUM
admet-661	450	26	)	)	PUNCT
admet-661	450	27	106	106	NUM
admet-661	450	28	-	-	SYM
admet-661	450	29	130	130	NUM
admet-661	450	30	128	128	NUM
admet-661	451	1	[	[	X
admet-661	451	2	22	22	NUM
admet-661	451	3	]	]	X
admet-661	451	4	y.m	y.m	PROPN
admet-661	451	5	.	.	PROPN
admet-661	451	6	chen	chen	PROPN
admet-661	451	7	,	,	PUNCT
admet-661	451	8	n.	n.	PROPN
admet-661	451	9	rodríguez	rodríguez	PROPN
admet-661	451	10	-	-	PUNCT
admet-661	451	11	hornedo	hornedo	PROPN
admet-661	451	12	.	.	PUNCT
admet-661	452	1	cocrystals	cocrystal	NOUN
admet-661	452	2	mitigate	mitigate	VERB
admet-661	452	3	negative	negative	ADJ
admet-661	452	4	effects	effect	NOUN
admet-661	452	5	of	of	ADP
admet-661	452	6	high	high	ADJ
admet-661	452	7	ph	ph	NOUN
admet-661	452	8	on	on	ADP
admet-661	452	9	solubility	solubility	NOUN
admet-661	452	10	and	and	CCONJ
admet-661	452	11	dissolution	dissolution	NOUN
admet-661	452	12	of	of	ADP
admet-661	452	13	a	a	DET
admet-661	452	14	basic	basic	ADJ
admet-661	452	15	drug	drug	NOUN
admet-661	452	16	.	.	PUNCT
admet-661	453	1	crystal	crystal	NOUN
admet-661	453	2	growth	growth	PROPN
admet-661	453	3	&	&	CCONJ
admet-661	453	4	design	design	PROPN
admet-661	453	5	18	18	NUM
admet-661	453	6	(	(	PUNCT
admet-661	453	7	2018	2018	NUM
admet-661	453	8	)	)	PUNCT
admet-661	453	9	1358	1358	NUM
admet-661	453	10	-	-	SYM
admet-661	453	11	1366	1366	NUM
admet-661	453	12	.	.	PUNCT
admet-661	454	1	[	[	X
admet-661	454	2	23	23	NUM
admet-661	454	3	]	]	X
admet-661	454	4	m.r	m.r	PROPN
admet-661	454	5	.	.	PROPN
admet-661	454	6	shimpi	shimpi	PROPN
admet-661	454	7	,	,	PUNCT
admet-661	454	8	a.	a.	PROPN
admet-661	454	9	alhayali	alhayali	PROPN
admet-661	454	10	,	,	PUNCT
admet-661	454	11	k.l	k.l	PROPN
admet-661	454	12	.	.	PROPN
admet-661	454	13	cavanagh	cavanagh	PROPN
admet-661	454	14	,	,	PUNCT
admet-661	454	15	n.	n.	PROPN
admet-661	454	16	rodríguez	rodríguez	PROPN
admet-661	454	17	-	-	PUNCT
admet-661	454	18	hornedo	hornedo	PROPN
admet-661	454	19	,	,	PUNCT
admet-661	454	20	s.p	s.p	PROPN
admet-661	454	21	.	.	PROPN
admet-661	454	22	velaga	velaga	NOUN
admet-661	454	23	.	.	PUNCT
admet-661	455	1	tadalafil	tadalafil	NOUN
admet-661	455	2	–	–	PUNCT
admet-661	455	3	malonic	malonic	ADJ
admet-661	455	4	acid	acid	NOUN
admet-661	455	5	cocrystal	cocrystal	NOUN
admet-661	455	6	:	:	PUNCT
admet-661	455	7	physicochemical	physicochemical	ADJ
admet-661	455	8	characterization	characterization	NOUN
admet-661	455	9	,	,	PUNCT
admet-661	455	10	ph	ph	NOUN
admet-661	455	11	-	-	NOUN
admet-661	455	12	solubility	solubility	NOUN
admet-661	455	13	,	,	PUNCT
admet-661	455	14	and	and	CCONJ
admet-661	455	15	supersaturation	supersaturation	NOUN
admet-661	455	16	studies	study	NOUN
admet-661	455	17	.	.	PUNCT
admet-661	456	1	crystal	crystal	NOUN
admet-661	456	2	growth	growth	PROPN
admet-661	456	3	&	&	CCONJ
admet-661	456	4	design	design	PROPN
admet-661	456	5	18	18	NUM
admet-661	456	6	(	(	PUNCT
admet-661	456	7	2018	2018	NUM
admet-661	456	8	)	)	PUNCT
admet-661	456	9	4378	4378	NUM
admet-661	456	10	-	-	SYM
admet-661	456	11	4387	4387	NUM
admet-661	456	12	.	.	PUNCT
admet-661	457	1	[	[	X
admet-661	457	2	24	24	NUM
admet-661	457	3	]	]	SYM
admet-661	457	4	n.j	n.j	PROPN
admet-661	457	5	.	.	PROPN
admet-661	457	6	babu	babu	PROPN
admet-661	457	7	,	,	PUNCT
admet-661	457	8	a.	a.	PROPN
admet-661	457	9	nangia	nangia	PROPN
admet-661	457	10	.	.	PUNCT
admet-661	458	1	solubility	solubility	NOUN
admet-661	458	2	advantage	advantage	NOUN
admet-661	458	3	of	of	ADP
admet-661	458	4	amorphous	amorphous	ADJ
admet-661	458	5	drugs	drug	NOUN
admet-661	458	6	and	and	CCONJ
admet-661	458	7	pharmaceutical	pharmaceutical	NOUN
admet-661	458	8	cocrystals	cocrystal	NOUN
admet-661	458	9	.	.	PUNCT
admet-661	459	1	crystal	crystal	NOUN
admet-661	459	2	growth	growth	PROPN
admet-661	459	3	&	&	CCONJ
admet-661	459	4	design	design	PROPN
admet-661	459	5	11	11	NUM
admet-661	459	6	(	(	PUNCT
admet-661	459	7	2011	2011	NUM
admet-661	459	8	)	)	PUNCT
admet-661	459	9	2662	2662	NUM
admet-661	459	10	-	-	SYM
admet-661	459	11	2679	2679	NUM
admet-661	459	12	.	.	PUNCT
admet-661	460	1	[	[	X
admet-661	460	2	25	25	NUM
admet-661	460	3	]	]	X
admet-661	460	4	k.l	k.l	PROPN
admet-661	460	5	.	.	PROPN
admet-661	460	6	cavanagh	cavanagh	PROPN
admet-661	460	7	,	,	PUNCT
admet-661	460	8	c.	c.	PROPN
admet-661	460	9	maheshwari	maheshwari	PROPN
admet-661	460	10	,	,	PUNCT
admet-661	460	11	n.	n.	PROPN
admet-661	460	12	rodríguez	rodríguez	PROPN
admet-661	460	13	-	-	PUNCT
admet-661	460	14	hornedo	hornedo	NOUN
admet-661	460	15	.	.	PUNCT
admet-661	461	1	understanding	understand	VERB
admet-661	461	2	the	the	DET
admet-661	461	3	differences	difference	NOUN
admet-661	461	4	between	between	ADP
admet-661	461	5	cocrystal	cocrystal	ADJ
admet-661	461	6	and	and	CCONJ
admet-661	461	7	salt	salt	NOUN
admet-661	461	8	aqueous	aqueous	ADJ
admet-661	461	9	solubilities	solubility	NOUN
admet-661	461	10	.	.	PUNCT
admet-661	462	1	journal	journal	PROPN
admet-661	462	2	of	of	ADP
admet-661	462	3	pharmaceutical	pharmaceutical	PROPN
admet-661	462	4	sciences	science	NOUN
admet-661	462	5	107	107	NUM
admet-661	462	6	(	(	PUNCT
admet-661	462	7	2018	2018	NUM
admet-661	462	8	)	)	PUNCT
admet-661	462	9	113	113	NUM
admet-661	462	10	-	-	SYM
admet-661	462	11	120	120	NUM
admet-661	462	12	.	.	PUNCT
admet-661	463	1	[	[	X
admet-661	463	2	26	26	NUM
admet-661	463	3	]	]	PUNCT
admet-661	463	4	a.	a.	NOUN
admet-661	463	5	avdeef	avdeef	PROPN
admet-661	463	6	.	.	PUNCT
admet-661	464	1	cocrystal	cocrystal	PROPN
admet-661	464	2	solubility	solubility	NOUN
admet-661	464	3	product	product	NOUN
admet-661	464	4	prediction	prediction	NOUN
admet-661	464	5	using	use	VERB
admet-661	464	6	an	an	DET
admet-661	464	7	in	in	ADP
admet-661	464	8	combo	combo	NOUN
admet-661	464	9	model	model	NOUN
admet-661	464	10	and	and	CCONJ
admet-661	464	11	simulations	simulation	NOUN
admet-661	464	12	to	to	PART
admet-661	464	13	improve	improve	VERB
admet-661	464	14	design	design	NOUN
admet-661	464	15	of	of	ADP
admet-661	464	16	experiments	experiment	NOUN
admet-661	464	17	.	.	PUNCT
admet-661	465	1	pharmaceutical	pharmaceutical	ADJ
admet-661	465	2	research	research	NOUN
admet-661	465	3	35	35	NUM
admet-661	465	4	(	(	PUNCT
admet-661	465	5	2018	2018	NUM
admet-661	465	6	)	)	PUNCT
admet-661	465	7	40	40	NUM
admet-661	465	8	.	.	PUNCT
admet-661	466	1	[	[	X
admet-661	466	2	27	27	NUM
admet-661	466	3	]	]	X
admet-661	466	4	m.t	m.t	PROPN
admet-661	466	5	.	.	PROPN
admet-661	466	6	esclusa	esclusa	PROPN
admet-661	466	7	-	-	PUNCT
admet-661	466	8	diaz	diaz	PROPN
admet-661	466	9	,	,	PUNCT
admet-661	466	10	m.	m.	NOUN
admet-661	466	11	guimaraens	guimaraens	PROPN
admet-661	466	12	-	-	PUNCT
admet-661	466	13	méndez	méndez	NOUN
admet-661	466	14	,	,	PUNCT
admet-661	466	15	m.b	m.b	PROPN
admet-661	466	16	.	.	PROPN
admet-661	466	17	pérez	pérez	PROPN
admet-661	466	18	-	-	PUNCT
admet-661	466	19	marcos	marcos	PROPN
admet-661	466	20	,	,	PUNCT
admet-661	466	21	j.l	j.l	PROPN
admet-661	466	22	.	.	PROPN
admet-661	466	23	vila	vila	PROPN
admet-661	466	24	-	-	PUNCT
admet-661	466	25	jato	jato	PROPN
admet-661	466	26	,	,	PUNCT
admet-661	466	27	j.j	j.j	PROPN
admet-661	466	28	.	.	PROPN
admet-661	466	29	torres	torres	PROPN
admet-661	466	30	-	-	PUNCT
admet-661	466	31	labandeira	labandeira	NOUN
admet-661	466	32	.	.	PUNCT
admet-661	467	1	characterization	characterization	NOUN
admet-661	467	2	and	and	CCONJ
admet-661	467	3	in	in	ADP
admet-661	467	4	vitro	vitro	X
admet-661	467	5	dissolution	dissolution	NOUN
admet-661	467	6	behaviour	behaviour	NOUN
admet-661	467	7	of	of	ADP
admet-661	467	8	ketoconazole	ketoconazole	PROPN
admet-661	467	9	/	/	SYM
admet-661	467	10	βand	βand	NOUN
admet-661	467	11	2	2	NUM
admet-661	467	12	-	-	PUNCT
admet-661	467	13	hydroxypropyl	hydroxypropyl	NOUN
admet-661	467	14	-	-	PUNCT
admet-661	467	15	βcyclodextrin	βcyclodextrin	NOUN
admet-661	467	16	inclusion	inclusion	NOUN
admet-661	467	17	compounds	compound	NOUN
admet-661	467	18	.	.	PUNCT
admet-661	468	1	international	international	ADJ
admet-661	468	2	journal	journal	PROPN
admet-661	468	3	of	of	ADP
admet-661	468	4	pharmaceutics	pharmaceutic	NOUN
admet-661	468	5	143	143	NUM
admet-661	468	6	(	(	PUNCT
admet-661	468	7	1996	1996	NUM
admet-661	468	8	)	)	PUNCT
admet-661	468	9	203	203	NUM
admet-661	468	10	-	-	SYM
admet-661	468	11	210	210	NUM
admet-661	468	12	.	.	PUNCT
admet-661	469	1	[	[	X
admet-661	469	2	28	28	NUM
admet-661	469	3	]	]	X
admet-661	469	4	f.a	f.a	PROPN
admet-661	469	5	.	.	PROPN
admet-661	469	6	martin	martin	PROPN
admet-661	469	7	,	,	PUNCT
admet-661	469	8	m.m	m.m	PROPN
admet-661	469	9	.	.	PROPN
admet-661	469	10	pop	pop	PROPN
admet-661	469	11	,	,	PUNCT
admet-661	469	12	g.	g.	PROPN
admet-661	469	13	borodi	borodi	PROPN
admet-661	469	14	,	,	PUNCT
admet-661	469	15	x.	x.	PROPN
admet-661	469	16	filip	filip	PROPN
admet-661	469	17	,	,	PUNCT
admet-661	469	18	i.	i.	PROPN
admet-661	469	19	kacso	kacso	PROPN
admet-661	469	20	.	.	PUNCT
admet-661	470	1	ketoconazole	ketoconazole	PROPN
admet-661	470	2	salt	salt	NOUN
admet-661	470	3	and	and	CCONJ
admet-661	470	4	co	co	NOUN
admet-661	470	5	-	-	NOUN
admet-661	470	6	crystals	crystal	NOUN
admet-661	470	7	with	with	ADP
admet-661	470	8	enhanced	enhanced	ADJ
admet-661	470	9	aqueous	aqueous	ADJ
admet-661	470	10	solubility	solubility	NOUN
admet-661	470	11	.	.	PUNCT
admet-661	471	1	crystal	crystal	NOUN
admet-661	471	2	growth	growth	PROPN
admet-661	471	3	&	&	CCONJ
admet-661	471	4	design	design	PROPN
admet-661	471	5	13	13	NUM
admet-661	471	6	(	(	PUNCT
admet-661	471	7	2013	2013	NUM
admet-661	471	8	)	)	PUNCT
admet-661	471	9	4295	4295	NUM
admet-661	471	10	-	-	SYM
admet-661	471	11	4304	4304	NUM
admet-661	471	12	.	.	PUNCT
admet-661	472	1	[	[	X
admet-661	472	2	29	29	NUM
admet-661	472	3	]	]	X
admet-661	472	4	a.t.m	a.t.m	X
admet-661	472	5	.	.	PUNCT
admet-661	472	6	serajuddin	serajuddin	PROPN
admet-661	472	7	,	,	PUNCT
admet-661	472	8	c.i	c.i	PROPN
admet-661	472	9	.	.	PROPN
admet-661	472	10	jarowski	jarowski	PROPN
admet-661	472	11	.	.	PUNCT
admet-661	473	1	effect	effect	NOUN
admet-661	473	2	of	of	ADP
admet-661	473	3	diffusion	diffusion	NOUN
admet-661	473	4	layer	layer	NOUN
admet-661	473	5	ph	ph	NOUN
admet-661	473	6	and	and	CCONJ
admet-661	473	7	solubility	solubility	NOUN
admet-661	473	8	on	on	ADP
admet-661	473	9	the	the	DET
admet-661	473	10	dissolution	dissolution	NOUN
admet-661	473	11	rate	rate	NOUN
admet-661	473	12	of	of	ADP
admet-661	473	13	pharmaceutical	pharmaceutical	ADJ
admet-661	473	14	acids	acid	NOUN
admet-661	473	15	and	and	CCONJ
admet-661	473	16	their	their	PRON
admet-661	473	17	sodium	sodium	NOUN
admet-661	473	18	salts	salt	NOUN
admet-661	473	19	.	.	PUNCT
admet-661	474	1	ii	ii	NOUN
admet-661	474	2	:	:	PUNCT
admet-661	474	3	salicylic	salicylic	ADJ
admet-661	474	4	acid	acid	NOUN
admet-661	474	5	,	,	PUNCT
admet-661	474	6	theophylline	theophylline	NOUN
admet-661	474	7	,	,	PUNCT
admet-661	474	8	and	and	CCONJ
admet-661	474	9	benzoic	benzoic	ADJ
admet-661	474	10	acid	acid	NOUN
admet-661	474	11	.	.	PUNCT
admet-661	475	1	journal	journal	PROPN
admet-661	475	2	of	of	ADP
admet-661	475	3	pharmaceutical	pharmaceutical	NOUN
admet-661	475	4	sciences	science	NOUN
admet-661	475	5	74	74	NUM
admet-661	475	6	(	(	PUNCT
admet-661	475	7	1985	1985	NUM
admet-661	475	8	)	)	PUNCT
admet-661	475	9	148	148	NUM
admet-661	475	10	-	-	SYM
admet-661	475	11	154	154	NUM
admet-661	475	12	.	.	PUNCT
admet-661	476	1	[	[	X
admet-661	476	2	30	30	NUM
admet-661	476	3	]	]	X
admet-661	476	4	a.t.m	a.t.m	X
admet-661	476	5	.	.	PUNCT
admet-661	476	6	serajuddin	serajuddin	PROPN
admet-661	476	7	,	,	PUNCT
admet-661	476	8	c.i	c.i	PROPN
admet-661	476	9	.	.	PROPN
admet-661	476	10	jarowski	jarowski	PROPN
admet-661	476	11	.	.	PUNCT
admet-661	477	1	effect	effect	NOUN
admet-661	477	2	of	of	ADP
admet-661	477	3	diffusion	diffusion	NOUN
admet-661	477	4	layer	layer	NOUN
admet-661	477	5	ph	ph	NOUN
admet-661	477	6	and	and	CCONJ
admet-661	477	7	solubility	solubility	NOUN
admet-661	477	8	on	on	ADP
admet-661	477	9	the	the	DET
admet-661	477	10	dissolution	dissolution	NOUN
admet-661	477	11	rate	rate	NOUN
admet-661	477	12	of	of	ADP
admet-661	477	13	pharmaceutical	pharmaceutical	NOUN
admet-661	477	14	bases	basis	NOUN
admet-661	477	15	and	and	CCONJ
admet-661	477	16	their	their	PRON
admet-661	477	17	hydrochloride	hydrochloride	NOUN
admet-661	477	18	salts	salt	NOUN
admet-661	477	19	i	i	PRON
admet-661	477	20	:	:	PUNCT
admet-661	477	21	phenazopyridine	phenazopyridine	PROPN
admet-661	477	22	.	.	PUNCT
admet-661	478	1	journal	journal	PROPN
admet-661	478	2	of	of	ADP
admet-661	478	3	pharmaceutical	pharmaceutical	NOUN
admet-661	478	4	sciences	science	NOUN
admet-661	478	5	74	74	NUM
admet-661	478	6	(	(	PUNCT
admet-661	478	7	1985	1985	NUM
admet-661	478	8	)	)	PUNCT
admet-661	478	9	142	142	NUM
admet-661	478	10	-	-	SYM
admet-661	478	11	147	147	NUM
admet-661	478	12	.	.	PUNCT
admet-661	479	1	[	[	X
admet-661	479	2	31	31	NUM
admet-661	479	3	]	]	SYM
admet-661	479	4	a.t.m	a.t.m	X
admet-661	479	5	.	.	PUNCT
admet-661	480	1	serajuddin	serajuddin	PROPN
admet-661	480	2	.	.	PUNCT
admet-661	481	1	m.	m.	NOUN
admet-661	481	2	pudipeddi	pudipeddi	NOUN
admet-661	481	3	,	,	PUNCT
admet-661	481	4	d.	d.	PROPN
admet-661	481	5	j.	j.	PROPN
admet-661	481	6	w.	w.	PROPN
admet-661	481	7	grant	grant	PROPN
admet-661	481	8	,	,	PUNCT
admet-661	482	1	p.	p.	PROPN
admet-661	482	2	h.	h.	PROPN
admet-661	482	3	stahl	stahl	PROPN
admet-661	482	4	.	.	PUNCT
admet-661	483	1	solubility	solubility	NOUN
admet-661	483	2	and	and	CCONJ
admet-661	483	3	dissolution	dissolution	NOUN
admet-661	483	4	of	of	ADP
admet-661	483	5	weak	weak	ADJ
admet-661	483	6	acids	acid	NOUN
admet-661	483	7	,	,	PUNCT
admet-661	483	8	bases	basis	NOUN
admet-661	483	9	,	,	PUNCT
admet-661	483	10	and	and	CCONJ
admet-661	483	11	salts	salt	NOUN
admet-661	483	12	.	.	PUNCT
admet-661	484	1	in	in	ADP
admet-661	484	2	handbook	handbook	NOUN
admet-661	484	3	of	of	ADP
admet-661	484	4	pharmaceutical	pharmaceutical	ADJ
admet-661	484	5	salts	salt	NOUN
admet-661	484	6	:	:	PUNCT
admet-661	484	7	properties	property	NOUN
admet-661	484	8	,	,	PUNCT
admet-661	484	9	selection	selection	NOUN
admet-661	484	10	,	,	PUNCT
admet-661	484	11	and	and	CCONJ
admet-661	484	12	use	use	NOUN
admet-661	484	13	.	.	PUNCT
admet-661	485	1	,	,	PUNCT
admet-661	485	2	wiley	wiley	PROPN
admet-661	485	3	-	-	PUNCT
admet-661	485	4	vch	vch	PROPN
admet-661	485	5	,	,	PUNCT
admet-661	485	6	zurich	zurich	PROPN
admet-661	485	7	,	,	PUNCT
admet-661	485	8	switzerland	switzerland	PROPN
admet-661	485	9	,	,	PUNCT
admet-661	485	10	2002	2002	NUM
admet-661	485	11	,	,	PUNCT
admet-661	485	12	pp	pp	ADJ
admet-661	485	13	.	.	PUNCT
admet-661	486	1	19	19	NUM
admet-661	486	2	-	-	SYM
admet-661	486	3	39	39	NUM
admet-661	486	4	.	.	PUNCT
admet-661	487	1	[	[	X
admet-661	487	2	32	32	NUM
admet-661	487	3	]	]	SYM
admet-661	487	4	a.t	a.t	PROPN
admet-661	487	5	.	.	PUNCT
admet-661	487	6	serajuddin	serajuddin	PROPN
admet-661	487	7	.	.	PUNCT
admet-661	488	1	salt	salt	NOUN
admet-661	488	2	formation	formation	NOUN
admet-661	488	3	to	to	PART
admet-661	488	4	improve	improve	VERB
admet-661	488	5	drug	drug	NOUN
admet-661	488	6	solubility	solubility	NOUN
admet-661	488	7	.	.	PUNCT
admet-661	489	1	advanced	advanced	ADJ
admet-661	489	2	drug	drug	NOUN
admet-661	489	3	delivery	delivery	NOUN
admet-661	489	4	reviews	review	VERB
admet-661	489	5	59	59	NUM
admet-661	489	6	(	(	PUNCT
admet-661	489	7	2007	2007	NUM
admet-661	489	8	)	)	PUNCT
admet-661	489	9	603	603	NUM
admet-661	489	10	-	-	SYM
admet-661	489	11	616	616	NUM
admet-661	489	12	.	.	PUNCT
admet-661	490	1	[	[	X
admet-661	490	2	33	33	NUM
admet-661	490	3	]	]	PUNCT
admet-661	490	4	s.	s.	PROPN
admet-661	490	5	li	li	PROPN
admet-661	490	6	,	,	PUNCT
admet-661	490	7	s.	s.	PROPN
admet-661	490	8	wong	wong	PROPN
admet-661	490	9	,	,	PUNCT
admet-661	490	10	s.	s.	PROPN
admet-661	490	11	sethia	sethia	PROPN
admet-661	490	12	,	,	PUNCT
admet-661	490	13	h.	h.	PROPN
admet-661	490	14	almoazen	almoazen	PROPN
admet-661	490	15	,	,	PUNCT
admet-661	490	16	y.m	y.m	PROPN
admet-661	490	17	.	.	PROPN
admet-661	490	18	joshi	joshi	PROPN
admet-661	490	19	,	,	PUNCT
admet-661	490	20	a.t	a.t	PROPN
admet-661	490	21	.	.	PUNCT
admet-661	490	22	serajuddin	serajuddin	PROPN
admet-661	490	23	.	.	PUNCT
admet-661	491	1	investigation	investigation	NOUN
admet-661	491	2	of	of	ADP
admet-661	491	3	solubility	solubility	NOUN
admet-661	491	4	and	and	CCONJ
admet-661	491	5	dissolution	dissolution	NOUN
admet-661	491	6	of	of	ADP
admet-661	491	7	a	a	DET
admet-661	491	8	free	free	ADJ
admet-661	491	9	base	base	NOUN
admet-661	491	10	and	and	CCONJ
admet-661	491	11	two	two	NUM
admet-661	491	12	different	different	ADJ
admet-661	491	13	salt	salt	NOUN
admet-661	491	14	forms	form	NOUN
admet-661	491	15	as	as	ADP
admet-661	491	16	a	a	DET
admet-661	491	17	function	function	NOUN
admet-661	491	18	of	of	ADP
admet-661	491	19	ph	ph	PROPN
admet-661	491	20	.	.	PROPN
admet-661	491	21	pharmaceutical	pharmaceutical	PROPN
admet-661	491	22	research	research	NOUN
admet-661	491	23	22	22	NUM
admet-661	491	24	(	(	PUNCT
admet-661	491	25	2005	2005	NUM
admet-661	491	26	)	)	PUNCT
admet-661	491	27	628	628	NUM
admet-661	491	28	-	-	SYM
admet-661	491	29	635	635	NUM
admet-661	491	30	.	.	PUNCT
admet-661	492	1	[	[	X
admet-661	492	2	34	34	NUM
admet-661	492	3	]	]	PUNCT
admet-661	492	4	a.	a.	NOUN
admet-661	492	5	avdeef	avdeef	PROPN
admet-661	492	6	,	,	PUNCT
admet-661	492	7	e.	e.	PROPN
admet-661	492	8	fuguet	fuguet	PROPN
admet-661	492	9	,	,	PUNCT
admet-661	492	10	a.	a.	PROPN
admet-661	492	11	llinàs	llinàs	PROPN
admet-661	492	12	,	,	PUNCT
admet-661	492	13	c.	c.	PROPN
admet-661	492	14	ràfols	ràfols	PROPN
admet-661	492	15	,	,	PUNCT
admet-661	492	16	e.	e.	PROPN
admet-661	492	17	bosch	bosch	PROPN
admet-661	492	18	,	,	PUNCT
admet-661	492	19	g.	g.	PROPN
admet-661	492	20	völgyi	völgyi	PROPN
admet-661	492	21	,	,	PUNCT
admet-661	492	22	t.	t.	NOUN
admet-661	492	23	verbić	verbić	PROPN
admet-661	492	24	,	,	PUNCT
admet-661	492	25	e.	e.	PROPN
admet-661	492	26	boldyreva	boldyreva	PROPN
admet-661	492	27	,	,	PUNCT
admet-661	492	28	k.	k.	PROPN
admet-661	492	29	takács	takács	PROPN
admet-661	492	30	-	-	PUNCT
admet-661	492	31	novák	novák	PROPN
admet-661	492	32	.	.	PUNCT
admet-661	492	33	equilibrium	equilibrium	NOUN
admet-661	492	34	solubility	solubility	NOUN
admet-661	492	35	measurement	measurement	NOUN
admet-661	492	36	of	of	ADP
admet-661	492	37	ionizable	ionizable	ADJ
admet-661	492	38	drugs	drug	NOUN
admet-661	492	39	–	–	PUNCT
admet-661	492	40	consensus	consensus	NOUN
admet-661	492	41	recommendations	recommendation	NOUN
admet-661	492	42	for	for	ADP
admet-661	492	43	improving	improve	VERB
admet-661	492	44	data	datum	NOUN
admet-661	492	45	quality	quality	NOUN
admet-661	492	46	.	.	PUNCT
admet-661	493	1	admet	admet	PROPN
admet-661	493	2	&	&	CCONJ
admet-661	493	3	dmpk	dmpk	PROPN
admet-661	493	4	4	4	NUM
admet-661	493	5	(	(	PUNCT
admet-661	493	6	2016	2016	NUM
admet-661	493	7	)	)	PUNCT
admet-661	493	8	117	117	NUM
admet-661	493	9	-	-	SYM
admet-661	493	10	178	178	NUM
admet-661	493	11	.	.	PUNCT
admet-661	494	1	(	(	PUNCT
admet-661	494	2	http://dx.doi.org/10.5599/admet.4.2.292	http://dx.doi.org/10.5599/admet.4.2.292	NUM
admet-661	494	3	)	)	PUNCT
admet-661	495	1	[	[	X
admet-661	495	2	35	35	NUM
admet-661	495	3	]	]	X
admet-661	495	4	o.s	o.s	PROPN
admet-661	495	5	.	.	PROPN
admet-661	495	6	marković	marković	PROPN
admet-661	495	7	,	,	PUNCT
admet-661	495	8	m.p	m.p	PROPN
admet-661	495	9	.	.	PROPN
admet-661	495	10	pešić	pešić	PROPN
admet-661	495	11	,	,	PUNCT
admet-661	495	12	a.v	a.v	PROPN
admet-661	495	13	.	.	PROPN
admet-661	495	14	shah	shah	PROPN
admet-661	495	15	,	,	PUNCT
admet-661	495	16	a.t.m	a.t.m	PROPN
admet-661	495	17	.	.	PUNCT
admet-661	496	1	serajuddin	serajuddin	PROPN
admet-661	496	2	,	,	PUNCT
admet-661	496	3	t.ž	t.ž	PROPN
admet-661	496	4	.	.	PROPN
admet-661	496	5	verbić	verbić	PROPN
admet-661	496	6	,	,	PUNCT
admet-661	496	7	a.	a.	NOUN
admet-661	496	8	avdeef	avdeef	PROPN
admet-661	496	9	.	.	PUNCT
admet-661	497	1	solubility	solubility	NOUN
admet-661	497	2	-	-	PUNCT
admet-661	497	3	ph	ph	NOUN
admet-661	497	4	profile	profile	NOUN
admet-661	497	5	of	of	ADP
admet-661	497	6	desipramine	desipramine	NOUN
admet-661	497	7	hydrochloride	hydrochloride	NOUN
admet-661	497	8	in	in	ADP
admet-661	497	9	saline	saline	ADJ
admet-661	497	10	phosphate	phosphate	NOUN
admet-661	497	11	buffer	buffer	NOUN
admet-661	497	12	:	:	PUNCT
admet-661	497	13	enhanced	enhance	VERB
admet-661	497	14	solubility	solubility	NOUN
admet-661	497	15	due	due	ADP
admet-661	497	16	to	to	ADP
admet-661	497	17	drug	drug	NOUN
admet-661	497	18	-	-	PUNCT
admet-661	497	19	buffer	buffer	NOUN
admet-661	497	20	aggregates	aggregate	NOUN
admet-661	497	21	.	.	PUNCT
admet-661	498	1	european	european	ADJ
admet-661	498	2	journal	journal	PROPN
admet-661	498	3	of	of	ADP
admet-661	498	4	pharmaceutical	pharmaceutical	PROPN
admet-661	498	5	sciences	science	NOUN
admet-661	498	6	(	(	PUNCT
admet-661	498	7	2019	2019	NUM
admet-661	498	8	)	)	PUNCT
admet-661	498	9	.	.	PUNCT
admet-661	499	1	(	(	PUNCT
admet-661	499	2	https://doi.org/10.1016/j.ejps.2019.03.014	https://doi.org/10.1016/j.ejps.2019.03.014	NUM
admet-661	499	3	)	)	PUNCT
admet-661	500	1	[	[	X
admet-661	500	2	36	36	NUM
admet-661	500	3	]	]	X
admet-661	500	4	s.l	s.l	PROPN
admet-661	500	5	.	.	PROPN
admet-661	500	6	childs	childs	PROPN
admet-661	500	7	,	,	PUNCT
admet-661	500	8	g.p	g.p	PROPN
admet-661	500	9	.	.	PROPN
admet-661	500	10	stahly	stahly	ADV
admet-661	500	11	,	,	PUNCT
admet-661	500	12	a.	a.	NOUN
admet-661	500	13	park	park	NOUN
admet-661	500	14	.	.	PUNCT
admet-661	501	1	the	the	DET
admet-661	501	2	salt−cocrystal	salt−cocrystal	ADJ
admet-661	501	3	continuum	continuum	ADJ
admet-661	501	4	:	:	PUNCT
admet-661	501	5	 	 	SPACE
admet-661	501	6	the	the	DET
admet-661	501	7	influence	influence	NOUN
admet-661	501	8	of	of	ADP
admet-661	501	9	crystal	crystal	NOUN
admet-661	501	10	structure	structure	NOUN
admet-661	501	11	on	on	ADP
admet-661	501	12	ionization	ionization	NOUN
admet-661	501	13	state	state	NOUN
admet-661	501	14	.	.	PUNCT
admet-661	502	1	molecular	molecular	ADJ
admet-661	502	2	pharmaceutics	pharmaceutic	NOUN
admet-661	502	3	4	4	NUM
admet-661	502	4	(	(	PUNCT
admet-661	502	5	2007	2007	NUM
admet-661	502	6	)	)	PUNCT
admet-661	502	7	323	323	NUM
admet-661	502	8	-	-	SYM
admet-661	502	9	338	338	NUM
admet-661	502	10	.	.	PUNCT
admet-661	503	1	[	[	X
admet-661	503	2	37	37	NUM
admet-661	503	3	]	]	X
admet-661	503	4	m.m	m.m	PROPN
admet-661	503	5	.	.	PROPN
admet-661	503	6	al	al	PROPN
admet-661	503	7	-	-	PUNCT
admet-661	503	8	shalalfeh	shalalfeh	PROPN
admet-661	503	9	,	,	PUNCT
admet-661	503	10	a.t	a.t	PROPN
admet-661	503	11	.	.	PROPN
admet-661	503	12	onawole	onawole	PROPN
admet-661	503	13	,	,	PUNCT
admet-661	503	14	t.a	t.a	PROPN
admet-661	503	15	.	.	PROPN
admet-661	503	16	saleh	saleh	PROPN
admet-661	503	17	,	,	PUNCT
admet-661	503	18	a.a	a.a	PROPN
admet-661	503	19	.	.	PROPN
admet-661	503	20	al	al	PROPN
admet-661	503	21	-	-	PUNCT
admet-661	503	22	saadi	saadi	NOUN
admet-661	503	23	.	.	PUNCT
admet-661	504	1	spherical	spherical	ADJ
admet-661	504	2	silver	silver	NOUN
admet-661	504	3	nanoparticles	nanoparticle	NOUN
admet-661	504	4	as	as	ADP
admet-661	504	5	substrates	substrate	NOUN
admet-661	504	6	in	in	ADP
admet-661	504	7	surface	surface	NOUN
admet-661	504	8	-	-	PUNCT
admet-661	504	9	enhanced	enhance	VERB
admet-661	504	10	raman	raman	NOUN
admet-661	504	11	spectroscopy	spectroscopy	NOUN
admet-661	504	12	for	for	ADP
admet-661	504	13	enhanced	enhanced	ADJ
admet-661	504	14	characterization	characterization	NOUN
admet-661	504	15	of	of	ADP
admet-661	504	16	ketoconazole	ketoconazole	NOUN
admet-661	504	17	.	.	PUNCT
admet-661	505	1	materials	material	NOUN
admet-661	505	2	science	science	PROPN
admet-661	505	3	&	&	CCONJ
admet-661	505	4	engineering	engineering	PROPN
admet-661	505	5	.	.	PUNCT
admet-661	506	1	c	c	X
admet-661	506	2	,	,	PUNCT
admet-661	506	3	materials	material	NOUN
admet-661	506	4	for	for	ADP
admet-661	506	5	biological	biological	ADJ
admet-661	506	6	applications	application	NOUN
admet-661	506	7	76	76	NUM
admet-661	506	8	(	(	PUNCT
admet-661	506	9	2017	2017	NUM
admet-661	506	10	)	)	PUNCT
admet-661	506	11	356	356	NUM
admet-661	506	12	-	-	SYM
admet-661	506	13	364	364	NUM
admet-661	506	14	.	.	PUNCT
admet-661	507	1	[	[	X
admet-661	507	2	38	38	NUM
admet-661	507	3	]	]	PUNCT
admet-661	507	4	m.	m.	PROPN
admet-661	507	5	suzuki	suzuki	PROPN
admet-661	507	6	,	,	PUNCT
admet-661	507	7	t.	t.	PROPN
admet-661	507	8	shimanouchi	shimanouchi	PROPN
admet-661	507	9	.	.	PUNCT
admet-661	508	1	infrared	infrared	PROPN
admet-661	508	2	and	and	CCONJ
admet-661	508	3	raman	raman	ADJ
admet-661	508	4	spectra	spectra	NOUN
admet-661	508	5	of	of	ADP
admet-661	508	6	succinic	succinic	ADJ
admet-661	508	7	acid	acid	NOUN
admet-661	508	8	crystal	crystal	NOUN
admet-661	508	9	.	.	PUNCT
admet-661	509	1	journal	journal	NOUN
admet-661	509	2	of	of	ADP
admet-661	509	3	molecular	molecular	ADJ
admet-661	509	4	spectroscopy	spectroscopy	NOUN
admet-661	509	5	28	28	NUM
admet-661	509	6	(	(	PUNCT
admet-661	509	7	1968	1968	NUM
admet-661	509	8	)	)	PUNCT
admet-661	509	9	394	394	NUM
admet-661	509	10	-	-	SYM
admet-661	509	11	410	410	NUM
admet-661	509	12	.	.	PUNCT
admet-661	510	1	[	[	X
admet-661	510	2	39	39	NUM
admet-661	510	3	]	]	X
admet-661	510	4	a.h	a.h	PROPN
admet-661	510	5	.	.	PROPN
admet-661	510	6	hosmani	hosmani	PROPN
admet-661	510	7	,	,	PUNCT
admet-661	510	8	y.s	y.s	PROPN
admet-661	510	9	.	.	PROPN
admet-661	510	10	thorat	thorat	NOUN
admet-661	510	11	.	.	PUNCT
admet-661	510	12	synthesis	synthesis	NOUN
admet-661	510	13	and	and	CCONJ
admet-661	510	14	evaluation	evaluation	NOUN
admet-661	510	15	of	of	ADP
admet-661	510	16	nanostructured	nanostructure	VERB
admet-661	510	17	particles	particle	NOUN
admet-661	510	18	of	of	ADP
admet-661	510	19	salt	salt	NOUN
admet-661	510	20	of	of	ADP
admet-661	510	21	ketoconazole	ketoconazole	NOUN
admet-661	510	22	for	for	ADP
admet-661	510	23	solubility	solubility	NOUN
admet-661	510	24	enhancement	enhancement	NOUN
admet-661	510	25	.	.	PUNCT
admet-661	511	1	digest	digest	PROPN
admet-661	511	2	journal	journal	PROPN
admet-661	511	3	of	of	ADP
admet-661	511	4	nanomaterials	nanomaterial	NOUN
admet-661	511	5	and	and	CCONJ
admet-661	511	6	biostructures	biostructure	NOUN
admet-661	511	7	6	6	NUM
admet-661	511	8	(	(	PUNCT
admet-661	511	9	2011	2011	NUM
admet-661	511	10	)	)	PUNCT
admet-661	511	11	1411	1411	NUM
admet-661	511	12	-	-	SYM
admet-661	511	13	1418	1418	NUM
admet-661	511	14	.	.	PUNCT
admet-661	512	1	admet	admet	PROPN
admet-661	512	2	&	&	CCONJ
admet-661	512	3	dmpk	dmpk	PROPN
admet-661	512	4	7(2	7(2	NUM
admet-661	512	5	)	)	PUNCT
admet-661	512	6	(	(	PUNCT
admet-661	512	7	2019	2019	NUM
admet-661	512	8	)	)	PUNCT
admet-661	512	9	106	106	NUM
admet-661	512	10	-	-	SYM
admet-661	512	11	130	130	NUM
admet-661	512	12	solubility	solubility	NOUN
admet-661	512	13	and	and	CCONJ
admet-661	512	14	dissolution	dissolution	NOUN
admet-661	512	15	of	of	ADP
admet-661	512	16	cocrystals	cocrystal	NOUN
admet-661	512	17	doi	doi	NOUN
admet-661	512	18	:	:	PUNCT
admet-661	512	19	10.5599	10.5599	NUM
admet-661	512	20	/	/	SYM
admet-661	512	21	admet.661	admet.661	NOUN
admet-661	512	22	129	129	NUM
admet-661	512	23	[	[	X
admet-661	512	24	40	40	NUM
admet-661	512	25	]	]	PUNCT
admet-661	512	26	m.	m.	NOUN
admet-661	512	27	pudipeddi	pudipeddi	NOUN
admet-661	512	28	,	,	PUNCT
admet-661	512	29	e.a	e.a	PROPN
admet-661	512	30	.	.	PROPN
admet-661	512	31	zannou	zannou	PROPN
admet-661	512	32	,	,	PUNCT
admet-661	512	33	m.	m.	NOUN
admet-661	512	34	vasanthavada	vasanthavada	PROPN
admet-661	512	35	,	,	PUNCT
admet-661	512	36	a.	a.	NOUN
admet-661	512	37	dontabhaktuni	dontabhaktuni	PROPN
admet-661	512	38	,	,	PUNCT
admet-661	512	39	a.e	a.e	PROPN
admet-661	512	40	.	.	PROPN
admet-661	512	41	royce	royce	PROPN
admet-661	512	42	,	,	PUNCT
admet-661	512	43	y.m	y.m	PROPN
admet-661	512	44	.	.	PROPN
admet-661	512	45	joshi	joshi	PROPN
admet-661	512	46	,	,	PUNCT
admet-661	512	47	a.t.m	a.t.m	PROPN
admet-661	512	48	.	.	PUNCT
admet-661	513	1	serajuddin	serajuddin	PROPN
admet-661	513	2	.	.	PUNCT
admet-661	514	1	measurement	measurement	NOUN
admet-661	514	2	of	of	ADP
admet-661	514	3	surface	surface	NOUN
admet-661	514	4	ph	ph	NOUN
admet-661	514	5	of	of	ADP
admet-661	514	6	pharmaceutical	pharmaceutical	ADJ
admet-661	514	7	solids	solid	NOUN
admet-661	514	8	:	:	PUNCT
admet-661	514	9	a	a	DET
admet-661	514	10	critical	critical	ADJ
admet-661	514	11	evaluation	evaluation	NOUN
admet-661	514	12	of	of	ADP
admet-661	514	13	indicator	indicator	NOUN
admet-661	514	14	dye	dye	NOUN
admet-661	514	15	-	-	PUNCT
admet-661	514	16	sorption	sorption	NOUN
admet-661	514	17	method	method	NOUN
admet-661	514	18	and	and	CCONJ
admet-661	514	19	its	its	PRON
admet-661	514	20	comparison	comparison	NOUN
admet-661	514	21	with	with	ADP
admet-661	514	22	slurry	slurry	NOUN
admet-661	514	23	ph	ph	ADJ
admet-661	514	24	method	method	NOUN
admet-661	514	25	.	.	PUNCT
admet-661	515	1	journal	journal	NOUN
admet-661	515	2	of	of	ADP
admet-661	515	3	pharmaceutical	pharmaceutical	PROPN
admet-661	515	4	sciences	science	NOUN
admet-661	515	5	97	97	NUM
admet-661	515	6	(	(	PUNCT
admet-661	515	7	2008	2008	NUM
admet-661	515	8	)	)	PUNCT
admet-661	515	9	1831	1831	NUM
admet-661	515	10	-	-	SYM
admet-661	515	11	1842	1842	NUM
admet-661	515	12	.	.	PUNCT
admet-661	516	1	©	©	NOUN
admet-661	516	2	2019	2019	NUM
admet-661	516	3	by	by	ADP
admet-661	516	4	the	the	DET
admet-661	516	5	authors	author	NOUN
admet-661	516	6	;	;	PUNCT
admet-661	516	7	licensee	licensee	PROPN
admet-661	516	8	iapc	iapc	PROPN
admet-661	516	9	,	,	PUNCT
admet-661	516	10	zagreb	zagreb	PROPN
admet-661	516	11	,	,	PUNCT
admet-661	516	12	croatia	croatia	PROPN
admet-661	516	13	.	.	PUNCT
admet-661	517	1	this	this	DET
admet-661	517	2	article	article	NOUN
admet-661	517	3	is	be	AUX
admet-661	517	4	an	an	DET
admet-661	517	5	open	open	ADJ
admet-661	517	6	-	-	PUNCT
admet-661	517	7	access	access	NOUN
admet-661	517	8	article	article	NOUN
admet-661	517	9	distributed	distribute	VERB
admet-661	517	10	under	under	ADP
admet-661	517	11	the	the	DET
admet-661	517	12	terms	term	NOUN
admet-661	517	13	and	and	CCONJ
admet-661	517	14	conditions	condition	NOUN
admet-661	517	15	of	of	ADP
admet-661	517	16	the	the	DET
admet-661	517	17	creative	creative	ADJ
admet-661	517	18	commons	common	NOUN
admet-661	517	19	attribution	attribution	NOUN
admet-661	517	20	license	license	NOUN
admet-661	517	21	(	(	PUNCT
admet-661	517	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-661	517	23	)	)	PUNCT
admet-661	517	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN