id	sid	tid	token	lemma	pos
admet-667	1	1	physiologically	physiologically	ADV
admet-667	1	2	based	base	VERB
admet-667	1	3	pharmacokinetic	pharmacokinetic	ADJ
admet-667	1	4	(	(	PUNCT
admet-667	1	5	pbpk	pbpk	NOUN
admet-667	1	6	)	)	PUNCT
admet-667	1	7	modeling	modeling	NOUN
admet-667	1	8	and	and	CCONJ
admet-667	1	9	simulation	simulation	NOUN
admet-667	1	10	in	in	ADP
admet-667	1	11	drug	drug	NOUN
admet-667	1	12	discovery	discovery	PROPN
admet-667	1	13	and	and	CCONJ
admet-667	1	14	development	development	NOUN
admet-667	1	15	doi	doi	PROPN
admet-667	1	16	:	:	PUNCT
admet-667	1	17	10.5599	10.5599	NUM
admet-667	1	18	/	/	SYM
admet-667	1	19	admet.667	admet.667	NOUN
admet-667	1	20	1	1	NUM
admet-667	1	21	admet	admet	PROPN
admet-667	1	22	&	&	CCONJ
admet-667	1	23	dmpk	dmpk	PROPN
admet-667	1	24	7(1	7(1	PROPN
admet-667	1	25	)	)	PUNCT
admet-667	1	26	(	(	PUNCT
admet-667	1	27	2019	2019	NUM
admet-667	1	28	)	)	PUNCT
admet-667	1	29	1	1	NUM
admet-667	1	30	-	-	SYM
admet-667	1	31	3	3	NUM
admet-667	1	32	;	;	PUNCT
admet-667	1	33	doi	doi	NOUN
admet-667	1	34	:	:	PUNCT
admet-667	1	35	10.5599	10.5599	NUM
admet-667	1	36	/	/	SYM
admet-667	1	37	admet.667	admet.667	NOUN
admet-667	1	38	open	open	ADJ
admet-667	1	39	access	access	NOUN
admet-667	1	40	:	:	PUNCT
admet-667	1	41	issn	issn	PROPN
admet-667	1	42	:	:	PUNCT
admet-667	1	43	1848	1848	NUM
admet-667	1	44	-	-	SYM
admet-667	1	45	7718	7718	NUM
admet-667	1	46	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-667	1	47	editorial	editorial	NOUN
admet-667	1	48	physiologically	physiologically	ADV
admet-667	1	49	based	base	VERB
admet-667	1	50	pharmacokinetic	pharmacokinetic	ADJ
admet-667	1	51	(	(	PUNCT
admet-667	1	52	pbpk	pbpk	NOUN
admet-667	1	53	)	)	PUNCT
admet-667	1	54	modeling	modeling	NOUN
admet-667	1	55	and	and	CCONJ
admet-667	1	56	simulation	simulation	NOUN
admet-667	1	57	in	in	ADP
admet-667	1	58	drug	drug	NOUN
admet-667	1	59	discovery	discovery	PROPN
admet-667	1	60	and	and	CCONJ
admet-667	1	61	development	development	NOUN
admet-667	1	62	abdul	abdul	PROPN
admet-667	1	63	naveed	naveed	PROPN
admet-667	1	64	shaik1	shaik1	PROPN
admet-667	1	65	*	*	PROPN
admet-667	1	66	,	,	PUNCT
admet-667	1	67	ansar	ansar	PROPN
admet-667	1	68	ali	ali	PROPN
admet-667	1	69	khan2	khan2	PROPN
admet-667	1	70	guest	guest	NOUN
admet-667	1	71	editors	editor	NOUN
admet-667	1	72	;	;	PUNCT
admet-667	1	73	admet	admet	PROPN
admet-667	1	74	&	&	CCONJ
admet-667	1	75	dmpk	dmpk	PROPN
admet-667	1	76	1	1	NUM
admet-667	1	77	simulations	simulation	NOUN
admet-667	1	78	plus	plus	CCONJ
admet-667	1	79	inc	inc	PROPN
admet-667	1	80	.	.	PROPN
admet-667	1	81	,	,	PUNCT
admet-667	1	82	lancaster	lancaster	PROPN
admet-667	1	83	,	,	PUNCT
admet-667	1	84	ca	ca	PROPN
admet-667	1	85	.	.	PUNCT
admet-667	2	1	usa	usa	PROPN
admet-667	2	2	2	2	NUM
admet-667	2	3	gvk	gvk	NOUN
admet-667	2	4	biosciences	bioscience	NOUN
admet-667	2	5	.	.	PUNCT
admet-667	3	1	hyderabad	hyderabad	PROPN
admet-667	3	2	,	,	PUNCT
admet-667	3	3	ts	ts	PROPN
admet-667	3	4	.	.	PUNCT
admet-667	4	1	india	india	PROPN
admet-667	4	2	*	*	PUNCT
admet-667	4	3	corresponding	correspond	VERB
admet-667	4	4	author	author	NOUN
admet-667	4	5	:	:	PUNCT
admet-667	4	6	e	e	NOUN
admet-667	4	7	-	-	NOUN
admet-667	4	8	mail	mail	NOUN
admet-667	4	9	:	:	PUNCT
admet-667	4	10	naveedshaik@gmail.com	naveedshaik@gmail.com	NUM
admet-667	4	11	;	;	PUNCT
admet-667	4	12	received	receive	VERB
admet-667	4	13	:	:	PUNCT
admet-667	4	14	february	february	PROPN
admet-667	4	15	19	19	NUM
admet-667	4	16	,	,	PUNCT
admet-667	4	17	2019	2019	NUM
admet-667	4	18	;	;	PUNCT
admet-667	4	19	published	publish	VERB
admet-667	4	20	:	:	PUNCT
admet-667	4	21	february	february	PROPN
admet-667	4	22	23	23	NUM
admet-667	4	23	,	,	PUNCT
admet-667	4	24	2019	2019	NUM
admet-667	4	25	physiologically	physiologically	ADV
admet-667	4	26	based	base	VERB
admet-667	4	27	pharmacokinetic	pharmacokinetic	ADJ
admet-667	4	28	(	(	PUNCT
admet-667	4	29	pbpk	pbpk	NOUN
admet-667	4	30	)	)	PUNCT
admet-667	4	31	modeling	modeling	NOUN
admet-667	4	32	is	be	AUX
admet-667	4	33	a	a	DET
admet-667	4	34	mechanistic	mechanistic	ADJ
admet-667	4	35	or	or	CCONJ
admet-667	4	36	physiology	physiology	NOUN
admet-667	4	37	based	base	VERB
admet-667	4	38	mathematical	mathematical	ADJ
admet-667	4	39	modeling	modeling	NOUN
admet-667	4	40	technique	technique	NOUN
admet-667	4	41	which	which	PRON
admet-667	4	42	integrates	integrate	VERB
admet-667	4	43	the	the	DET
admet-667	4	44	knowledge	knowledge	NOUN
admet-667	4	45	from	from	ADP
admet-667	4	46	both	both	DET
admet-667	4	47	drug	drug	NOUN
admet-667	4	48	-	-	PUNCT
admet-667	4	49	based	base	VERB
admet-667	4	50	properties	property	NOUN
admet-667	4	51	including	include	VERB
admet-667	4	52	physiochemical	physiochemical	ADJ
admet-667	4	53	and	and	CCONJ
admet-667	4	54	biopharmaceutical	biopharmaceutical	ADJ
admet-667	4	55	properties	property	NOUN
admet-667	4	56	and	and	CCONJ
admet-667	4	57	system	system	NOUN
admet-667	4	58	based	base	VERB
admet-667	4	59	or	or	CCONJ
admet-667	4	60	physiological	physiological	ADJ
admet-667	4	61	properties	property	NOUN
admet-667	4	62	to	to	PART
admet-667	4	63	generate	generate	VERB
admet-667	4	64	a	a	DET
admet-667	4	65	model	model	NOUN
admet-667	4	66	for	for	ADP
admet-667	4	67	predicting	predict	VERB
admet-667	4	68	the	the	DET
admet-667	4	69	absorption	absorption	NOUN
admet-667	4	70	,	,	PUNCT
admet-667	4	71	distribution	distribution	NOUN
admet-667	4	72	,	,	PUNCT
admet-667	4	73	metabolism	metabolism	NOUN
admet-667	4	74	and	and	CCONJ
admet-667	4	75	excretion	excretion	NOUN
admet-667	4	76	(	(	PUNCT
admet-667	4	77	adme	adme	NOUN
admet-667	4	78	)	)	PUNCT
admet-667	4	79	of	of	ADP
admet-667	4	80	a	a	DET
admet-667	4	81	drug	drug	NOUN
admet-667	4	82	as	as	ADV
admet-667	4	83	well	well	ADV
admet-667	4	84	as	as	ADP
admet-667	4	85	pharmacokinetic	pharmacokinetic	ADJ
admet-667	4	86	behavior	behavior	NOUN
admet-667	4	87	of	of	ADP
admet-667	4	88	a	a	DET
admet-667	4	89	drug	drug	NOUN
admet-667	4	90	in	in	ADP
admet-667	4	91	preclinical	preclinical	ADJ
admet-667	4	92	species	specie	NOUN
admet-667	4	93	and	and	CCONJ
admet-667	4	94	humans	human	NOUN
admet-667	4	95	.	.	PUNCT
admet-667	5	1	even	even	ADV
admet-667	5	2	though	though	SCONJ
admet-667	5	3	pbpk	pbpk	NOUN
admet-667	5	4	models	model	NOUN
admet-667	5	5	can	can	AUX
admet-667	5	6	provide	provide	VERB
admet-667	5	7	mechanistic	mechanistic	ADJ
admet-667	5	8	insights	insight	NOUN
admet-667	5	9	,	,	PUNCT
admet-667	5	10	it	it	PRON
admet-667	5	11	was	be	AUX
admet-667	5	12	seldom	seldom	ADV
admet-667	5	13	used	use	VERB
admet-667	5	14	for	for	ADP
admet-667	5	15	long	long	ADJ
admet-667	5	16	time	time	NOUN
admet-667	5	17	due	due	ADP
admet-667	5	18	to	to	ADP
admet-667	5	19	the	the	DET
admet-667	5	20	lack	lack	NOUN
admet-667	5	21	of	of	ADP
admet-667	5	22	highperformance	highperformance	NOUN
admet-667	5	23	computing	computing	NOUN
admet-667	5	24	systems	system	NOUN
admet-667	5	25	.	.	PUNCT
admet-667	6	1	with	with	ADP
admet-667	6	2	the	the	DET
admet-667	6	3	advent	advent	NOUN
admet-667	6	4	of	of	ADP
admet-667	6	5	high	high	ADJ
admet-667	6	6	-	-	PUNCT
admet-667	6	7	performance	performance	NOUN
admet-667	6	8	computing	computing	NOUN
admet-667	6	9	facilities	facility	NOUN
admet-667	6	10	,	,	PUNCT
admet-667	6	11	multiple	multiple	ADJ
admet-667	6	12	differential	differential	ADJ
admet-667	6	13	equations	equation	NOUN
admet-667	6	14	can	can	AUX
admet-667	6	15	be	be	AUX
admet-667	6	16	solved	solve	VERB
admet-667	6	17	at	at	ADP
admet-667	6	18	a	a	DET
admet-667	6	19	time	time	NOUN
admet-667	6	20	.	.	PUNCT
admet-667	7	1	development	development	NOUN
admet-667	7	2	of	of	ADP
admet-667	7	3	commercial	commercial	ADJ
admet-667	7	4	pbpk	pbpk	NOUN
admet-667	7	5	software	software	NOUN
admet-667	7	6	such	such	ADJ
admet-667	7	7	as	as	ADP
admet-667	7	8	pk	pk	NOUN
admet-667	7	9	-	-	ADJ
admet-667	7	10	sim	sim	NOUN
admet-667	7	11	(	(	PUNCT
admet-667	7	12	bayer	bayer	NOUN
admet-667	7	13	technology	technology	NOUN
admet-667	7	14	services	service	NOUN
admet-667	7	15	)	)	PUNCT
admet-667	7	16	,	,	PUNCT
admet-667	7	17	gastroplus	gastroplus	X
admet-667	7	18	(	(	PUNCT
admet-667	7	19	simulations	simulation	NOUN
admet-667	7	20	plus	plus	CCONJ
admet-667	7	21	inc	inc	PROPN
admet-667	7	22	.	.	PROPN
admet-667	7	23	)	)	PUNCT
admet-667	7	24	,	,	PUNCT
admet-667	7	25	simcyp	simcyp	NOUN
admet-667	7	26	(	(	PUNCT
admet-667	7	27	certara	certara	NOUN
admet-667	7	28	)	)	PUNCT
admet-667	7	29	,	,	PUNCT
admet-667	7	30	simbiology	simbiology	NOUN
admet-667	7	31	(	(	PUNCT
admet-667	7	32	mathworks	mathworks	PROPN
admet-667	7	33	)	)	PUNCT
admet-667	7	34	etc	etc	X
admet-667	7	35	.	.	X
admet-667	7	36	has	have	AUX
admet-667	7	37	resulted	result	VERB
admet-667	7	38	in	in	ADP
admet-667	7	39	increased	increase	VERB
admet-667	7	40	use	use	NOUN
admet-667	7	41	of	of	ADP
admet-667	7	42	pbpk	pbpk	NOUN
admet-667	7	43	in	in	ADP
admet-667	7	44	drug	drug	NOUN
admet-667	7	45	development	development	NOUN
admet-667	7	46	.	.	PUNCT
admet-667	8	1	pbpk	pbpk	PROPN
admet-667	8	2	models	model	NOUN
admet-667	8	3	can	can	AUX
admet-667	8	4	be	be	AUX
admet-667	8	5	used	use	VERB
admet-667	8	6	in	in	ADP
admet-667	8	7	different	different	ADJ
admet-667	8	8	phases	phase	NOUN
admet-667	8	9	of	of	ADP
admet-667	8	10	drug	drug	NOUN
admet-667	8	11	development	development	NOUN
admet-667	8	12	including	include	VERB
admet-667	8	13	the	the	DET
admet-667	8	14	first	first	ADJ
admet-667	8	15	in	in	ADP
admet-667	8	16	human	human	ADJ
admet-667	8	17	(	(	PUNCT
admet-667	8	18	fih	fih	NOUN
admet-667	8	19	)	)	PUNCT
admet-667	8	20	dose	dose	NOUN
admet-667	8	21	prediction	prediction	NOUN
admet-667	8	22	from	from	ADP
admet-667	8	23	preclinical	preclinical	ADJ
admet-667	8	24	data	datum	NOUN
admet-667	8	25	.	.	PUNCT
admet-667	9	1	in	in	ADP
admet-667	9	2	this	this	DET
admet-667	9	3	phase	phase	NOUN
admet-667	9	4	data	datum	NOUN
admet-667	9	5	generated	generate	VERB
admet-667	9	6	from	from	ADP
admet-667	9	7	in	in	ADP
admet-667	9	8	vitro	vitro	X
admet-667	9	9	experiments	experiment	NOUN
admet-667	9	10	as	as	ADV
admet-667	9	11	well	well	ADV
admet-667	9	12	as	as	ADP
admet-667	9	13	data	datum	NOUN
admet-667	9	14	from	from	ADP
admet-667	9	15	in	in	ADP
admet-667	9	16	silico	silico	NOUN
admet-667	9	17	predictions	prediction	NOUN
admet-667	9	18	can	can	AUX
admet-667	9	19	be	be	AUX
admet-667	9	20	integrated	integrate	VERB
admet-667	9	21	to	to	PART
admet-667	9	22	develop	develop	VERB
admet-667	9	23	model	model	NOUN
admet-667	9	24	which	which	PRON
admet-667	9	25	can	can	AUX
admet-667	9	26	then	then	ADV
admet-667	9	27	be	be	AUX
admet-667	9	28	used	use	VERB
admet-667	9	29	to	to	PART
admet-667	9	30	predict	predict	VERB
admet-667	9	31	fih	fih	NOUN
admet-667	9	32	dose	dose	NOUN
admet-667	9	33	range	range	NOUN
admet-667	9	34	.	.	PUNCT
admet-667	10	1	this	this	PRON
admet-667	10	2	is	be	AUX
admet-667	10	3	referred	refer	VERB
admet-667	10	4	as	as	ADP
admet-667	10	5	the	the	DET
admet-667	10	6	bottoms	bottom	NOUN
admet-667	10	7	up	up	ADP
admet-667	10	8	approach	approach	NOUN
admet-667	10	9	.	.	PUNCT
admet-667	11	1	on	on	ADP
admet-667	11	2	the	the	DET
admet-667	11	3	other	other	ADJ
admet-667	11	4	hand	hand	NOUN
admet-667	11	5	,	,	PUNCT
admet-667	11	6	in	in	ADP
admet-667	11	7	the	the	DET
admet-667	11	8	top	top	NOUN
admet-667	11	9	down	down	ADP
admet-667	11	10	approach	approach	NOUN
admet-667	11	11	,	,	PUNCT
admet-667	11	12	clinical	clinical	ADJ
admet-667	11	13	data	datum	NOUN
admet-667	11	14	can	can	AUX
admet-667	11	15	be	be	AUX
admet-667	11	16	used	use	VERB
admet-667	11	17	to	to	PART
admet-667	11	18	develop	develop	VERB
admet-667	11	19	and	and	CCONJ
admet-667	11	20	refine	refine	VERB
admet-667	11	21	the	the	DET
admet-667	11	22	pbpk	pbpk	ADJ
admet-667	11	23	model	model	NOUN
admet-667	11	24	.	.	PUNCT
admet-667	12	1	moreover	moreover	ADV
admet-667	12	2	,	,	PUNCT
admet-667	12	3	pbpk	pbpk	NOUN
admet-667	12	4	model	model	NOUN
admet-667	12	5	can	can	AUX
admet-667	12	6	be	be	AUX
admet-667	12	7	used	use	VERB
admet-667	12	8	to	to	PART
admet-667	12	9	evaluate	evaluate	VERB
admet-667	12	10	drug	drug	NOUN
admet-667	12	11	safety	safety	NOUN
admet-667	12	12	and	and	CCONJ
admet-667	12	13	toxicity	toxicity	NOUN
admet-667	12	14	,	,	PUNCT
admet-667	12	15	as	as	ADV
admet-667	12	16	well	well	ADV
admet-667	12	17	as	as	ADP
admet-667	12	18	the	the	DET
admet-667	12	19	prediction	prediction	NOUN
admet-667	12	20	of	of	ADP
admet-667	12	21	drug	drug	NOUN
admet-667	12	22	exposure	exposure	NOUN
admet-667	12	23	in	in	ADP
admet-667	12	24	different	different	ADJ
admet-667	12	25	conditions	condition	NOUN
admet-667	12	26	or	or	CCONJ
admet-667	12	27	populations	population	NOUN
admet-667	12	28	studying	study	VERB
admet-667	12	29	the	the	DET
admet-667	12	30	effect	effect	NOUN
admet-667	12	31	of	of	ADP
admet-667	12	32	age	age	NOUN
admet-667	12	33	,	,	PUNCT
admet-667	12	34	gender	gender	NOUN
admet-667	12	35	,	,	PUNCT
admet-667	12	36	ethnicity	ethnicity	NOUN
admet-667	12	37	disease	disease	NOUN
admet-667	12	38	state	state	NOUN
admet-667	12	39	etc	etc	X
admet-667	12	40	.	.	PUNCT
admet-667	13	1	these	these	DET
admet-667	13	2	models	model	NOUN
admet-667	13	3	are	be	AUX
admet-667	13	4	also	also	ADV
admet-667	13	5	commonly	commonly	ADV
admet-667	13	6	used	use	VERB
admet-667	13	7	in	in	ADP
admet-667	13	8	the	the	DET
admet-667	13	9	evaluation	evaluation	NOUN
admet-667	13	10	of	of	ADP
admet-667	13	11	drug	drug	NOUN
admet-667	13	12	-	-	PUNCT
admet-667	13	13	drug	drug	NOUN
admet-667	13	14	interaction	interaction	NOUN
admet-667	13	15	(	(	PUNCT
admet-667	13	16	ddi	ddi	PROPN
admet-667	13	17	)	)	PUNCT
admet-667	13	18	to	to	PART
admet-667	13	19	provide	provide	VERB
admet-667	13	20	insights	insight	NOUN
admet-667	13	21	into	into	ADP
admet-667	13	22	any	any	DET
admet-667	13	23	undesirable	undesirable	ADJ
admet-667	13	24	issues	issue	NOUN
admet-667	13	25	of	of	ADP
admet-667	13	26	the	the	DET
admet-667	13	27	investigative	investigative	ADJ
admet-667	13	28	new	new	ADJ
admet-667	13	29	drug	drug	NOUN
admet-667	13	30	(	(	PUNCT
admet-667	13	31	ind	ind	NOUN
admet-667	13	32	)	)	PUNCT
admet-667	13	33	with	with	ADP
admet-667	13	34	other	other	ADJ
admet-667	13	35	marketed	market	VERB
admet-667	13	36	drugs	drug	NOUN
admet-667	13	37	.	.	PUNCT
admet-667	14	1	recent	recent	ADJ
admet-667	14	2	advancement	advancement	NOUN
admet-667	14	3	in	in	ADP
admet-667	14	4	pbpk	pbpk	NOUN
admet-667	14	5	modeling	modeling	NOUN
admet-667	14	6	and	and	CCONJ
admet-667	14	7	the	the	DET
admet-667	14	8	understanding	understanding	NOUN
admet-667	14	9	of	of	ADP
admet-667	14	10	metabolizing	metabolize	VERB
admet-667	14	11	enzymes	enzyme	NOUN
admet-667	14	12	,	,	PUNCT
admet-667	14	13	drug	drug	NOUN
admet-667	14	14	transporters	transporter	NOUN
admet-667	14	15	and	and	CCONJ
admet-667	14	16	genetic	genetic	ADJ
admet-667	14	17	make	make	NOUN
admet-667	14	18	-	-	PUNCT
admet-667	14	19	up	up	NOUN
admet-667	14	20	of	of	ADP
admet-667	14	21	different	different	ADJ
admet-667	14	22	races	race	NOUN
admet-667	14	23	have	have	AUX
admet-667	14	24	led	lead	VERB
admet-667	14	25	to	to	ADP
admet-667	14	26	an	an	DET
admet-667	14	27	increase	increase	NOUN
admet-667	14	28	in	in	ADP
admet-667	14	29	the	the	DET
admet-667	14	30	use	use	NOUN
admet-667	14	31	of	of	ADP
admet-667	14	32	pbpk	pbpk	NOUN
admet-667	14	33	models	model	NOUN
admet-667	14	34	in	in	ADP
admet-667	14	35	drug	drug	NOUN
admet-667	14	36	discovery	discovery	NOUN
admet-667	14	37	and	and	CCONJ
admet-667	14	38	development	development	NOUN
admet-667	14	39	.	.	PUNCT
admet-667	15	1	these	these	DET
admet-667	15	2	models	model	NOUN
admet-667	15	3	can	can	AUX
admet-667	15	4	provide	provide	VERB
admet-667	15	5	a	a	DET
admet-667	15	6	simple	simple	NOUN
admet-667	15	7	in	in	ADP
admet-667	15	8	vitro	vitro	X
admet-667	15	9	in	in	ADP
admet-667	15	10	vivo	vivo	ADJ
admet-667	15	11	correlation	correlation	NOUN
admet-667	15	12	(	(	PUNCT
admet-667	15	13	ivivc	ivivc	PROPN
admet-667	15	14	)	)	PUNCT
admet-667	15	15	based	base	VERB
admet-667	15	16	on	on	ADP
admet-667	15	17	the	the	DET
admet-667	15	18	thorough	thorough	NOUN
admet-667	15	19	in	in	ADP
admet-667	15	20	vitro	vitro	X
admet-667	15	21	data	datum	NOUN
admet-667	15	22	from	from	ADP
admet-667	15	23	drug	drug	NOUN
admet-667	15	24	metabolism	metabolism	NOUN
admet-667	16	1	[	[	X
admet-667	16	2	1	1	NUM
admet-667	16	3	-	-	SYM
admet-667	16	4	3	3	NUM
admet-667	16	5	]	]	PUNCT
admet-667	16	6	and	and	CCONJ
admet-667	16	7	drug	drug	NOUN
admet-667	16	8	transporter	transporter	NOUN
admet-667	16	9	studies	study	NOUN
admet-667	16	10	[	[	X
admet-667	16	11	2	2	NUM
admet-667	16	12	,	,	PUNCT
admet-667	16	13	4	4	NUM
admet-667	16	14	]	]	PUNCT
admet-667	16	15	.	.	PUNCT
admet-667	17	1	pbpk	pbpk	PROPN
admet-667	17	2	is	be	AUX
admet-667	17	3	very	very	ADV
admet-667	17	4	useful	useful	ADJ
admet-667	17	5	in	in	ADP
admet-667	17	6	modelling	modelling	NOUN
admet-667	17	7	of	of	ADP
admet-667	17	8	:	:	PUNCT
admet-667	17	9	a	a	X
admet-667	17	10	)	)	PUNCT
admet-667	17	11	absorption	absorption	NOUN
admet-667	17	12	where	where	SCONJ
admet-667	17	13	the	the	DET
admet-667	17	14	model	model	NOUN
admet-667	17	15	takes	take	VERB
admet-667	17	16	into	into	ADP
admet-667	17	17	consideration	consideration	NOUN
admet-667	17	18	the	the	DET
admet-667	17	19	solubility	solubility	NOUN
admet-667	17	20	,	,	PUNCT
admet-667	17	21	dissolution	dissolution	NOUN
admet-667	17	22	,	,	PUNCT
admet-667	17	23	and	and	CCONJ
admet-667	17	24	permeability	permeability	NOUN
admet-667	17	25	both	both	CCONJ
admet-667	17	26	passive	passive	ADJ
admet-667	17	27	and	and	CCONJ
admet-667	17	28	active	active	ADJ
admet-667	17	29	with	with	ADP
admet-667	17	30	the	the	DET
admet-667	17	31	involvement	involvement	NOUN
admet-667	17	32	of	of	ADP
admet-667	17	33	transporters	transporter	NOUN
admet-667	17	34	,	,	PUNCT
admet-667	17	35	gut	gut	NOUN
admet-667	17	36	extraction	extraction	NOUN
admet-667	17	37	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-667	17	38	mailto:naveedshaik@gmail.com	mailto:naveedshaik@gmail.com	X
admet-667	18	1	shaik	shaik	PROPN
admet-667	18	2	and	and	CCONJ
admet-667	18	3	kahn	kahn	PROPN
admet-667	18	4	admet	admet	PROPN
admet-667	18	5	&	&	CCONJ
admet-667	18	6	dmpk	dmpk	PROPN
admet-667	18	7	7(1	7(1	PROPN
admet-667	18	8	)	)	PUNCT
admet-667	18	9	(	(	PUNCT
admet-667	18	10	2019	2019	NUM
admet-667	18	11	)	)	PUNCT
admet-667	18	12	1	1	NUM
admet-667	18	13	-	-	SYM
admet-667	18	14	3	3	NUM
admet-667	18	15	2	2	NUM
admet-667	18	16	through	through	ADP
admet-667	18	17	metabolism	metabolism	NOUN
admet-667	18	18	;	;	PUNCT
admet-667	18	19	b	b	X
admet-667	18	20	)	)	PUNCT
admet-667	18	21	distribution	distribution	NOUN
admet-667	18	22	where	where	SCONJ
admet-667	18	23	physiological	physiological	ADJ
admet-667	18	24	parameters	parameter	NOUN
admet-667	18	25	and	and	CCONJ
admet-667	18	26	compound	compound	VERB
admet-667	18	27	related	related	ADJ
admet-667	18	28	parameters	parameter	NOUN
admet-667	18	29	are	be	AUX
admet-667	18	30	taken	take	VERB
admet-667	18	31	into	into	ADP
admet-667	18	32	consideration	consideration	NOUN
admet-667	18	33	and	and	CCONJ
admet-667	18	34	various	various	ADJ
admet-667	18	35	equations	equation	NOUN
admet-667	18	36	can	can	AUX
admet-667	18	37	be	be	AUX
admet-667	18	38	applied	apply	VERB
admet-667	18	39	to	to	PART
admet-667	18	40	calculate	calculate	VERB
admet-667	18	41	the	the	DET
admet-667	18	42	tissue	tissue	NOUN
admet-667	18	43	partition	partition	NOUN
admet-667	18	44	coefficient	coefficient	NOUN
admet-667	18	45	(	(	PUNCT
admet-667	18	46	kp	kp	INTJ
admet-667	18	47	)	)	PUNCT
admet-667	18	48	for	for	ADP
admet-667	18	49	perfusion	perfusion	NOUN
admet-667	18	50	rate	rate	NOUN
admet-667	18	51	limited	limit	VERB
admet-667	18	52	or	or	CCONJ
admet-667	18	53	permeability	permeability	NOUN
admet-667	18	54	limited	limited	ADJ
admet-667	18	55	situations	situation	NOUN
admet-667	18	56	;	;	PUNCT
admet-667	18	57	c	c	X
admet-667	18	58	)	)	PUNCT
admet-667	18	59	metabolism	metabolism	NOUN
admet-667	18	60	where	where	SCONJ
admet-667	18	61	data	datum	NOUN
admet-667	18	62	from	from	ADP
admet-667	18	63	in	in	ADP
admet-667	18	64	vitro	vitro	X
admet-667	18	65	sources	source	NOUN
admet-667	18	66	including	include	VERB
admet-667	18	67	recombinant	recombinant	ADJ
admet-667	18	68	enzymes	enzyme	NOUN
admet-667	18	69	,	,	PUNCT
admet-667	18	70	liver	liver	NOUN
admet-667	18	71	microsomes	microsome	NOUN
admet-667	18	72	and	and	CCONJ
admet-667	18	73	hepatocytes	hepatocyte	NOUN
admet-667	18	74	and	and	CCONJ
admet-667	18	75	transporter	transporter	NOUN
admet-667	18	76	data	datum	NOUN
admet-667	18	77	from	from	ADP
admet-667	18	78	hepatocytes	hepatocyte	NOUN
admet-667	18	79	or	or	CCONJ
admet-667	18	80	over	over	ADP
admet-667	18	81	expressed	express	VERB
admet-667	18	82	cell	cell	NOUN
admet-667	18	83	lines	line	NOUN
admet-667	18	84	can	can	AUX
admet-667	18	85	be	be	AUX
admet-667	18	86	used	use	VERB
admet-667	18	87	to	to	PART
admet-667	18	88	inform	inform	VERB
admet-667	18	89	the	the	DET
admet-667	18	90	rate	rate	NOUN
admet-667	18	91	and	and	CCONJ
admet-667	18	92	extend	extend	VERB
admet-667	18	93	of	of	ADP
admet-667	18	94	in	in	ADP
admet-667	18	95	vivo	vivo	ADJ
admet-667	18	96	metabolism	metabolism	NOUN
admet-667	18	97	;	;	PUNCT
admet-667	18	98	d	d	X
admet-667	18	99	)	)	PUNCT
admet-667	18	100	excretion	excretion	NOUN
admet-667	18	101	through	through	ADP
admet-667	18	102	biliary	biliary	NOUN
admet-667	18	103	,	,	PUNCT
admet-667	18	104	renal	renal	ADJ
admet-667	18	105	routes	route	NOUN
admet-667	18	106	can	can	AUX
admet-667	18	107	be	be	AUX
admet-667	18	108	easily	easily	ADV
admet-667	18	109	modelled	model	VERB
admet-667	18	110	using	use	VERB
admet-667	18	111	pbpk	pbpk	ADJ
admet-667	18	112	models	model	NOUN
admet-667	18	113	.	.	PUNCT
admet-667	19	1	there	there	PRON
admet-667	19	2	is	be	VERB
admet-667	19	3	an	an	DET
admet-667	19	4	increase	increase	NOUN
admet-667	19	5	in	in	ADP
admet-667	19	6	the	the	DET
admet-667	19	7	acceptability	acceptability	NOUN
admet-667	19	8	of	of	ADP
admet-667	19	9	pbpk	pbpk	NOUN
admet-667	19	10	models	model	NOUN
admet-667	19	11	in	in	ADP
admet-667	19	12	drug	drug	NOUN
admet-667	19	13	submission	submission	NOUN
admet-667	19	14	package	package	NOUN
admet-667	19	15	by	by	ADP
admet-667	19	16	usfda	usfda	PROPN
admet-667	19	17	,	,	PUNCT
admet-667	19	18	ema	ema	PROPN
admet-667	19	19	and	and	CCONJ
admet-667	19	20	pmda	pmda	VERB
admet-667	19	21	as	as	ADP
admet-667	19	22	evident	evident	ADJ
admet-667	19	23	by	by	ADP
admet-667	19	24	the	the	DET
admet-667	19	25	fact	fact	NOUN
admet-667	19	26	that	that	SCONJ
admet-667	19	27	the	the	DET
admet-667	19	28	number	number	NOUN
admet-667	19	29	of	of	ADP
admet-667	19	30	ind	ind	NOUN
admet-667	19	31	applications	application	NOUN
admet-667	19	32	as	as	ADV
admet-667	19	33	well	well	ADV
admet-667	19	34	as	as	ADP
admet-667	19	35	submissions	submission	NOUN
admet-667	19	36	with	with	ADP
admet-667	19	37	ddis	ddi	NOUN
admet-667	19	38	and	and	CCONJ
admet-667	19	39	in	in	ADP
admet-667	19	40	special	special	ADJ
admet-667	19	41	populations	population	NOUN
admet-667	19	42	including	include	VERB
admet-667	19	43	paediatrics	paediatric	NOUN
admet-667	19	44	that	that	PRON
admet-667	19	45	involved	involve	VERB
admet-667	19	46	the	the	DET
admet-667	19	47	use	use	NOUN
admet-667	19	48	of	of	ADP
admet-667	19	49	pbpk	pbpk	NOUN
admet-667	19	50	have	have	AUX
admet-667	19	51	increased	increase	VERB
admet-667	19	52	significantly	significantly	ADV
admet-667	19	53	in	in	ADP
admet-667	19	54	the	the	DET
admet-667	19	55	recent	recent	ADJ
admet-667	19	56	years	year	NOUN
admet-667	19	57	by	by	ADP
admet-667	19	58	regulatory	regulatory	ADJ
admet-667	19	59	agencies	agency	NOUN
admet-667	19	60	.	.	PUNCT
admet-667	20	1	in	in	ADP
admet-667	20	2	particular	particular	ADJ
admet-667	20	3	,	,	PUNCT
admet-667	20	4	these	these	DET
admet-667	20	5	regulatory	regulatory	ADJ
admet-667	20	6	agencies	agency	NOUN
admet-667	20	7	have	have	AUX
admet-667	20	8	issued	issue	VERB
admet-667	20	9	guidance	guidance	NOUN
admet-667	20	10	for	for	ADP
admet-667	20	11	application	application	NOUN
admet-667	20	12	and	and	CCONJ
admet-667	20	13	use	use	NOUN
admet-667	20	14	of	of	ADP
admet-667	20	15	pbpk	pbpk	NOUN
admet-667	20	16	models	model	NOUN
admet-667	20	17	at	at	ADP
admet-667	20	18	various	various	ADJ
admet-667	20	19	stages	stage	NOUN
admet-667	20	20	of	of	ADP
admet-667	20	21	drug	drug	NOUN
admet-667	20	22	development	development	NOUN
admet-667	20	23	including	include	VERB
admet-667	20	24	,	,	PUNCT
admet-667	20	25	investigational	investigational	ADJ
admet-667	20	26	new	new	ADJ
admet-667	20	27	drug	drug	NOUN
admet-667	20	28	applications	application	NOUN
admet-667	20	29	(	(	PUNCT
admet-667	20	30	inds	ind	NOUN
admet-667	20	31	)	)	PUNCT
admet-667	20	32	,	,	PUNCT
admet-667	20	33	new	new	ADJ
admet-667	20	34	drug	drug	NOUN
admet-667	20	35	applications	application	NOUN
admet-667	20	36	(	(	PUNCT
admet-667	20	37	ndas	ndas	PROPN
admet-667	20	38	)	)	PUNCT
admet-667	20	39	,	,	PUNCT
admet-667	20	40	biologics	biologic	NOUN
admet-667	20	41	license	license	NOUN
admet-667	20	42	applications	application	NOUN
admet-667	20	43	(	(	PUNCT
admet-667	20	44	blas	blas	PROPN
admet-667	20	45	)	)	PUNCT
admet-667	20	46	,	,	PUNCT
admet-667	20	47	or	or	CCONJ
admet-667	20	48	abbreviated	abbreviate	VERB
admet-667	20	49	new	new	ADJ
admet-667	20	50	drug	drug	NOUN
admet-667	20	51	applications	application	NOUN
admet-667	20	52	(	(	PUNCT
admet-667	20	53	andas	andas	X
admet-667	20	54	)	)	PUNCT
admet-667	20	55	etc	etc	X
admet-667	20	56	.	.	X
admet-667	20	57	with	with	ADP
admet-667	20	58	the	the	DET
admet-667	20	59	increased	increase	VERB
admet-667	20	60	use	use	NOUN
admet-667	20	61	of	of	ADP
admet-667	20	62	pharmacodynamics	pharmacodynamic	NOUN
admet-667	20	63	(	(	PUNCT
admet-667	20	64	pd	pd	NOUN
admet-667	20	65	)	)	PUNCT
admet-667	20	66	with	with	ADP
admet-667	20	67	pbpk	pbpk	NOUN
admet-667	20	68	models	model	NOUN
admet-667	20	69	(	(	PUNCT
admet-667	20	70	pbpk	pbpk	PROPN
admet-667	20	71	-	-	PROPN
admet-667	20	72	pd	pd	NOUN
admet-667	20	73	)	)	PUNCT
admet-667	20	74	where	where	SCONJ
admet-667	20	75	simple	simple	ADJ
admet-667	20	76	pd	pd	NOUN
admet-667	20	77	models	model	NOUN
admet-667	20	78	can	can	AUX
admet-667	20	79	be	be	AUX
admet-667	20	80	linked	link	VERB
admet-667	20	81	to	to	ADP
admet-667	20	82	pbpk	pbpk	PROPN
admet-667	20	83	model	model	NOUN
admet-667	20	84	,	,	PUNCT
admet-667	20	85	it	it	PRON
admet-667	20	86	is	be	AUX
admet-667	20	87	anticipated	anticipate	VERB
admet-667	20	88	that	that	SCONJ
admet-667	20	89	pbpk	pbpk	PROPN
admet-667	20	90	model	model	NOUN
admet-667	20	91	-	-	PUNCT
admet-667	20	92	based	base	VERB
admet-667	20	93	drug	drug	NOUN
admet-667	20	94	development	development	NOUN
admet-667	20	95	is	be	AUX
admet-667	20	96	going	go	VERB
admet-667	20	97	to	to	PART
admet-667	20	98	be	be	AUX
admet-667	20	99	very	very	ADV
admet-667	20	100	popular	popular	ADJ
admet-667	20	101	in	in	ADP
admet-667	20	102	pharmaceutical	pharmaceutical	ADJ
admet-667	20	103	research	research	NOUN
admet-667	20	104	.	.	PUNCT
admet-667	21	1	in	in	ADP
admet-667	21	2	the	the	DET
admet-667	21	3	foreseeable	foreseeable	ADJ
admet-667	21	4	future	future	NOUN
admet-667	21	5	,	,	PUNCT
admet-667	21	6	we	we	PRON
admet-667	21	7	anticipate	anticipate	VERB
admet-667	21	8	that	that	SCONJ
admet-667	21	9	more	more	ADJ
admet-667	21	10	pharmaceutical	pharmaceutical	ADJ
admet-667	21	11	companies	company	NOUN
admet-667	21	12	and	and	CCONJ
admet-667	21	13	academicians	academician	NOUN
admet-667	21	14	are	be	AUX
admet-667	21	15	going	go	VERB
admet-667	21	16	to	to	PART
admet-667	21	17	adopt	adopt	VERB
admet-667	21	18	pbpk	pbpk	NOUN
admet-667	21	19	modeling	modeling	NOUN
admet-667	21	20	in	in	ADP
admet-667	21	21	their	their	PRON
admet-667	21	22	research	research	NOUN
admet-667	21	23	and	and	CCONJ
admet-667	21	24	drug	drug	NOUN
admet-667	21	25	development	development	NOUN
admet-667	21	26	projects	project	NOUN
admet-667	21	27	.	.	PUNCT
admet-667	22	1	with	with	ADP
admet-667	22	2	the	the	DET
admet-667	22	3	increase	increase	NOUN
admet-667	22	4	in	in	ADP
admet-667	22	5	the	the	DET
admet-667	22	6	number	number	NOUN
admet-667	22	7	of	of	ADP
admet-667	22	8	research	research	NOUN
admet-667	22	9	publication	publication	NOUN
admet-667	22	10	utilizing	utilize	VERB
admet-667	22	11	pbpk	pbpk	NOUN
admet-667	22	12	from	from	ADP
admet-667	22	13	industry	industry	NOUN
admet-667	22	14	,	,	PUNCT
admet-667	22	15	academia	academia	NOUN
admet-667	22	16	and	and	CCONJ
admet-667	22	17	regulatory	regulatory	ADJ
admet-667	22	18	authorities	authority	NOUN
admet-667	22	19	alike	alike	ADV
admet-667	22	20	and	and	CCONJ
admet-667	22	21	with	with	ADP
admet-667	22	22	the	the	DET
admet-667	22	23	success	success	NOUN
admet-667	22	24	of	of	ADP
admet-667	22	25	prior	prior	ADJ
admet-667	22	26	special	special	ADJ
admet-667	22	27	issues	issue	NOUN
admet-667	22	28	focused	focus	VERB
admet-667	22	29	on	on	ADP
admet-667	22	30	various	various	ADJ
admet-667	22	31	stages	stage	NOUN
admet-667	22	32	of	of	ADP
admet-667	22	33	drug	drug	NOUN
admet-667	22	34	development	development	NOUN
admet-667	22	35	we	we	PRON
admet-667	22	36	devoted	devote	VERB
admet-667	22	37	a	a	DET
admet-667	22	38	special	special	ADJ
admet-667	22	39	issue	issue	NOUN
admet-667	22	40	on	on	ADP
admet-667	22	41	“	"	PUNCT
admet-667	22	42	physiologically	physiologically	ADV
admet-667	22	43	based	base	VERB
admet-667	22	44	pharmacokinetic	pharmacokinetic	ADJ
admet-667	22	45	(	(	PUNCT
admet-667	22	46	pbpk	pbpk	NOUN
admet-667	22	47	)	)	PUNCT
admet-667	22	48	modeling	modeling	NOUN
admet-667	22	49	and	and	CCONJ
admet-667	22	50	simulation	simulation	NOUN
admet-667	22	51	in	in	ADP
admet-667	22	52	drug	drug	NOUN
admet-667	22	53	discovery	discovery	NOUN
admet-667	22	54	and	and	CCONJ
admet-667	22	55	development	development	NOUN
admet-667	22	56	”	"	PUNCT
admet-667	22	57	.	.	PUNCT
admet-667	23	1	we	we	PRON
admet-667	23	2	received	receive	VERB
admet-667	23	3	four	four	NUM
admet-667	23	4	original	original	ADJ
admet-667	23	5	articles	article	NOUN
admet-667	23	6	and	and	CCONJ
admet-667	23	7	a	a	DET
admet-667	23	8	review	review	NOUN
admet-667	23	9	article	article	NOUN
admet-667	23	10	for	for	ADP
admet-667	23	11	this	this	DET
admet-667	23	12	special	special	ADJ
admet-667	23	13	issue	issue	NOUN
admet-667	23	14	.	.	PUNCT
admet-667	24	1	these	these	DET
admet-667	24	2	articles	article	NOUN
admet-667	24	3	covered	cover	VERB
admet-667	24	4	varied	varied	ADJ
admet-667	24	5	areas	area	NOUN
admet-667	24	6	including	include	VERB
admet-667	24	7	“	"	PUNCT
admet-667	24	8	building	build	VERB
admet-667	24	9	“	"	PUNCT
admet-667	24	10	in	in	ADP
admet-667	24	11	-	-	PUNCT
admet-667	24	12	house	house	NOUN
admet-667	24	13	”	"	PUNCT
admet-667	24	14	pbpk	pbpk	NOUN
admet-667	24	15	modeling	modeling	NOUN
admet-667	24	16	tools	tool	NOUN
admet-667	24	17	for	for	ADP
admet-667	24	18	oral	oral	ADJ
admet-667	24	19	drug	drug	NOUN
admet-667	24	20	administration	administration	NOUN
admet-667	24	21	from	from	ADP
admet-667	24	22	literature	literature	PROPN
admet-667	24	23	information	information	NOUN
admet-667	24	24	”	"	PUNCT
admet-667	25	1	[	[	X
admet-667	25	2	5	5	NUM
admet-667	25	3	]	]	PUNCT
admet-667	25	4	where	where	SCONJ
admet-667	25	5	the	the	DET
admet-667	25	6	researchers	researcher	NOUN
admet-667	25	7	have	have	AUX
admet-667	25	8	shown	show	VERB
admet-667	25	9	how	how	SCONJ
admet-667	25	10	to	to	PART
admet-667	25	11	develop	develop	VERB
admet-667	25	12	in	in	ADP
admet-667	25	13	-	-	PUNCT
admet-667	25	14	house	house	NOUN
admet-667	25	15	pbpk	pbpk	NOUN
admet-667	25	16	tools	tool	NOUN
admet-667	25	17	from	from	ADP
admet-667	25	18	species	specie	NOUN
admet-667	25	19	-	-	PUNCT
admet-667	25	20	related	relate	VERB
admet-667	25	21	physiological	physiological	ADJ
admet-667	25	22	information	information	NOUN
admet-667	25	23	available	available	ADJ
admet-667	25	24	in	in	ADP
admet-667	25	25	the	the	DET
admet-667	25	26	literature	literature	NOUN
admet-667	25	27	and	and	CCONJ
admet-667	25	28	a	a	DET
admet-667	25	29	limited	limited	ADJ
admet-667	25	30	number	number	NOUN
admet-667	25	31	of	of	ADP
admet-667	25	32	drug	drug	NOUN
admet-667	25	33	specific	specific	ADJ
admet-667	25	34	parameters	parameter	NOUN
admet-667	25	35	and	and	CCONJ
admet-667	25	36	validated	validate	VERB
admet-667	25	37	the	the	DET
admet-667	25	38	in	in	ADP
admet-667	25	39	-	-	PUNCT
admet-667	25	40	house	house	NOUN
admet-667	25	41	pbpk	pbpk	NOUN
admet-667	25	42	tools	tool	NOUN
admet-667	25	43	with	with	ADP
admet-667	25	44	25	25	NUM
admet-667	25	45	compounds	compound	NOUN
admet-667	25	46	.	.	PUNCT
admet-667	26	1	another	another	DET
admet-667	26	2	research	research	NOUN
admet-667	26	3	article	article	NOUN
admet-667	26	4	entitled	entitle	VERB
admet-667	26	5	“	"	PUNCT
admet-667	26	6	a	a	DET
admet-667	26	7	physiologically	physiologically	ADV
admet-667	26	8	-	-	PUNCT
admet-667	26	9	based	base	VERB
admet-667	26	10	pharmacokinetic	pharmacokinetic	ADJ
admet-667	26	11	model	model	NOUN
admet-667	26	12	of	of	ADP
admet-667	26	13	oseltamivir	oseltamivir	PROPN
admet-667	26	14	phosphate	phosphate	VERB
admet-667	26	15	and	and	CCONJ
admet-667	26	16	its	its	PRON
admet-667	26	17	carboxylate	carboxylate	NOUN
admet-667	26	18	metabolite	metabolite	NOUN
admet-667	26	19	for	for	ADP
admet-667	26	20	rats	rat	NOUN
admet-667	26	21	and	and	CCONJ
admet-667	26	22	humans	human	NOUN
admet-667	26	23	”	"	PUNCT
admet-667	27	1	[	[	X
admet-667	27	2	6	6	NUM
admet-667	27	3	]	]	PUNCT
admet-667	27	4	where	where	SCONJ
admet-667	27	5	the	the	DET
admet-667	27	6	model	model	NOUN
admet-667	27	7	was	be	AUX
admet-667	27	8	built	build	VERB
admet-667	27	9	with	with	ADP
admet-667	27	10	both	both	CCONJ
admet-667	27	11	the	the	DET
admet-667	27	12	parent	parent	NOUN
admet-667	27	13	oseltamivir	oseltamivir	PROPN
admet-667	27	14	phosphate	phosphate	VERB
admet-667	27	15	and	and	CCONJ
admet-667	27	16	its	its	PRON
admet-667	27	17	carboxylate	carboxylate	NOUN
admet-667	27	18	metabolite	metabolite	NOUN
admet-667	27	19	.	.	PUNCT
admet-667	28	1	the	the	DET
admet-667	28	2	model	model	NOUN
admet-667	28	3	built	build	VERB
admet-667	28	4	in	in	ADP
admet-667	28	5	healthy	healthy	ADJ
admet-667	28	6	subjects	subject	NOUN
admet-667	28	7	has	have	AUX
admet-667	28	8	been	be	AUX
admet-667	28	9	applied	apply	VERB
admet-667	28	10	in	in	ADP
admet-667	28	11	disease	disease	NOUN
admet-667	28	12	-	-	PUNCT
admet-667	28	13	subjects	subject	NOUN
admet-667	28	14	as	as	ADV
admet-667	28	15	well	well	ADV
admet-667	28	16	as	as	ADP
admet-667	28	17	in	in	ADP
admet-667	28	18	subjects	subject	NOUN
admet-667	28	19	with	with	ADP
admet-667	28	20	liver	liver	NOUN
admet-667	28	21	or	or	CCONJ
admet-667	28	22	renal	renal	ADJ
admet-667	28	23	impairment	impairment	NOUN
admet-667	28	24	.	.	PUNCT
admet-667	29	1	one	one	NUM
admet-667	29	2	other	other	ADJ
admet-667	29	3	research	research	NOUN
admet-667	29	4	article	article	NOUN
admet-667	29	5	was	be	AUX
admet-667	29	6	titled	title	VERB
admet-667	29	7	"	"	PUNCT
admet-667	29	8	physiologically	physiologically	ADV
admet-667	29	9	-	-	PUNCT
admet-667	29	10	based	base	VERB
admet-667	29	11	pharmacokinetic	pharmacokinetic	ADJ
admet-667	29	12	simulations	simulation	NOUN
admet-667	29	13	in	in	ADP
admet-667	29	14	pharmacotherapy	pharmacotherapy	NOUN
admet-667	29	15	:	:	PUNCT
admet-667	29	16	selection	selection	NOUN
admet-667	29	17	of	of	ADP
admet-667	29	18	the	the	DET
admet-667	29	19	optimal	optimal	ADJ
admet-667	29	20	administration	administration	NOUN
admet-667	29	21	route	route	NOUN
admet-667	29	22	for	for	ADP
admet-667	29	23	exogenous	exogenous	ADJ
admet-667	29	24	melatonin	melatonin	NOUN
admet-667	29	25	"	"	PUNCT
admet-667	30	1	[	[	X
admet-667	30	2	7	7	X
admet-667	30	3	]	]	PUNCT
admet-667	30	4	where	where	SCONJ
admet-667	30	5	the	the	DET
admet-667	30	6	authors	author	NOUN
admet-667	30	7	showed	show	VERB
admet-667	30	8	the	the	DET
admet-667	30	9	significance	significance	NOUN
admet-667	30	10	of	of	ADP
admet-667	30	11	pbpk	pbpk	ADJ
admet-667	30	12	model	model	NOUN
admet-667	30	13	in	in	ADP
admet-667	30	14	dose	dose	NOUN
admet-667	30	15	optimization	optimization	NOUN
admet-667	30	16	and	and	CCONJ
admet-667	30	17	selection	selection	NOUN
admet-667	30	18	of	of	ADP
admet-667	30	19	route	route	NOUN
admet-667	30	20	of	of	ADP
admet-667	30	21	administration	administration	NOUN
admet-667	30	22	.	.	PUNCT
admet-667	31	1	one	one	NUM
admet-667	31	2	article	article	NOUN
admet-667	31	3	of	of	ADP
admet-667	31	4	a	a	DET
admet-667	31	5	great	great	ADJ
admet-667	31	6	interest	interest	NOUN
admet-667	31	7	was	be	AUX
admet-667	31	8	a	a	DET
admet-667	31	9	review	review	NOUN
admet-667	31	10	entitled	entitle	VERB
admet-667	31	11	“	"	PUNCT
admet-667	31	12	pbpk	pbpk	NOUN
admet-667	31	13	modelling	modelling	NOUN
admet-667	31	14	of	of	ADP
admet-667	31	15	highly	highly	ADV
admet-667	31	16	lipid	lipid	ADJ
admet-667	31	17	soluble	soluble	ADJ
admet-667	31	18	and	and	CCONJ
admet-667	31	19	extracellular	extracellular	ADJ
admet-667	31	20	solutes	solute	NOUN
admet-667	31	21	”	"	PUNCT
admet-667	31	22	[	[	X
admet-667	31	23	8	8	NUM
admet-667	31	24	]	]	PUNCT
admet-667	31	25	,	,	PUNCT
admet-667	31	26	which	which	PRON
admet-667	31	27	extensively	extensively	ADV
admet-667	31	28	discussed	discuss	VERB
admet-667	31	29	two	two	NUM
admet-667	31	30	classes	class	NOUN
admet-667	31	31	of	of	ADP
admet-667	31	32	drugs	drug	NOUN
admet-667	31	33	,	,	PUNCT
admet-667	31	34	namely	namely	ADV
admet-667	31	35	the	the	DET
admet-667	31	36	highly	highly	ADV
admet-667	31	37	lipid	lipid	ADJ
admet-667	31	38	soluble	soluble	ADJ
admet-667	31	39	(	(	PUNCT
admet-667	31	40	hls	hls	NOUN
admet-667	31	41	)	)	PUNCT
admet-667	31	42	solutes	solute	NOUN
admet-667	31	43	,	,	PUNCT
admet-667	31	44	and	and	CCONJ
admet-667	31	45	the	the	DET
admet-667	31	46	extracellular	extracellular	ADJ
admet-667	31	47	(	(	PUNCT
admet-667	31	48	ecs	ecs	NOUN
admet-667	31	49	)	)	PUNCT
admet-667	31	50	solutes	solute	NOUN
admet-667	31	51	.	.	PUNCT
admet-667	32	1	these	these	DET
admet-667	32	2	submissions	submission	NOUN
admet-667	32	3	clearly	clearly	ADV
admet-667	32	4	indicate	indicate	VERB
admet-667	32	5	the	the	DET
admet-667	32	6	utilization	utilization	NOUN
admet-667	32	7	and	and	CCONJ
admet-667	32	8	significance	significance	NOUN
admet-667	32	9	of	of	ADP
admet-667	32	10	pbpk	pbpk	NOUN
admet-667	32	11	in	in	ADP
admet-667	32	12	various	various	ADJ
admet-667	32	13	stages	stage	NOUN
admet-667	32	14	of	of	ADP
admet-667	32	15	drug	drug	NOUN
admet-667	32	16	development	development	NOUN
admet-667	32	17	.	.	PUNCT
admet-667	33	1	references	reference	NOUN
admet-667	33	2	[	[	X
admet-667	33	3	1	1	NUM
admet-667	33	4	]	]	X
admet-667	33	5	a.n	a.n	PROPN
admet-667	33	6	.	.	PROPN
admet-667	33	7	shaik	shaik	PROPN
admet-667	33	8	.	.	PUNCT
admet-667	34	1	changing	change	VERB
admet-667	34	2	trends	trend	NOUN
admet-667	34	3	in	in	ADP
admet-667	34	4	use	use	NOUN
admet-667	34	5	of	of	ADP
admet-667	34	6	hepatocytes	hepatocyte	NOUN
admet-667	34	7	and	and	CCONJ
admet-667	34	8	microsomes	microsome	NOUN
admet-667	34	9	for	for	ADP
admet-667	34	10	evaluating	evaluate	VERB
admet-667	34	11	metabolism	metabolism	NOUN
admet-667	34	12	studies	study	NOUN
admet-667	34	13	in	in	ADP
admet-667	34	14	drug	drug	NOUN
admet-667	34	15	discovery	discovery	NOUN
admet-667	34	16	.	.	PUNCT
admet-667	35	1	admet	admet	PROPN
admet-667	35	2	and	and	CCONJ
admet-667	35	3	dmpk	dmpk	VERB
admet-667	35	4	4	4	NUM
admet-667	35	5	(	(	PUNCT
admet-667	35	6	2016	2016	NUM
admet-667	35	7	)	)	PUNCT
admet-667	35	8	60	60	NUM
admet-667	35	9	-	-	SYM
admet-667	35	10	61	61	NUM
admet-667	35	11	.	.	PUNCT
admet-667	36	1	[	[	X
admet-667	36	2	2	2	X
admet-667	36	3	]	]	PUNCT
admet-667	36	4	s.	s.	PROPN
admet-667	36	5	basu	basu	PROPN
admet-667	36	6	,	,	PUNCT
admet-667	36	7	a.n	a.n	PROPN
admet-667	36	8	.	.	PROPN
admet-667	36	9	shaik	shaik	PROPN
admet-667	36	10	.	.	PUNCT
admet-667	36	11	is	be	AUX
admet-667	36	12	there	there	PRON
admet-667	36	13	a	a	DET
admet-667	36	14	paradigm	paradigm	NOUN
admet-667	36	15	shift	shift	NOUN
admet-667	36	16	in	in	ADP
admet-667	36	17	use	use	NOUN
admet-667	36	18	of	of	ADP
admet-667	36	19	microsomes	microsome	NOUN
admet-667	36	20	and	and	CCONJ
admet-667	36	21	hepatocytes	hepatocyte	NOUN
admet-667	36	22	in	in	ADP
admet-667	36	23	drug	drug	NOUN
admet-667	36	24	discovery	discovery	NOUN
admet-667	36	25	and	and	CCONJ
admet-667	36	26	development	development	NOUN
admet-667	36	27	?	?	PUNCT
admet-667	37	1	admet	admet	PROPN
admet-667	37	2	and	and	CCONJ
admet-667	37	3	dmpk	dmpk	VERB
admet-667	37	4	4	4	NUM
admet-667	37	5	(	(	PUNCT
admet-667	37	6	2016	2016	NUM
admet-667	37	7	)	)	PUNCT
admet-667	37	8	114	114	NUM
admet-667	37	9	-	-	SYM
admet-667	37	10	116	116	NUM
admet-667	37	11	.	.	PUNCT
admet-667	38	1	admet	admet	PROPN
admet-667	38	2	&	&	CCONJ
admet-667	38	3	dmpk	dmpk	PROPN
admet-667	38	4	7(1	7(1	PROPN
admet-667	38	5	)	)	PUNCT
admet-667	38	6	(	(	PUNCT
admet-667	38	7	2019	2019	NUM
admet-667	38	8	)	)	PUNCT
admet-667	38	9	000	000	NUM
admet-667	38	10	-	-	PUNCT
admet-667	38	11	000	000	NUM
admet-667	38	12	running	running	NOUN
admet-667	38	13	title	title	NOUN
admet-667	38	14	doi	doi	NOUN
admet-667	38	15	:	:	PUNCT
admet-667	38	16	10.5599	10.5599	NUM
admet-667	38	17	/	/	SYM
admet-667	38	18	admet.667	admet.667	NOUN
admet-667	38	19	3	3	NUM
admet-667	38	20	[	[	X
admet-667	38	21	3	3	NUM
admet-667	38	22	]	]	X
admet-667	38	23	a.n	a.n	PROPN
admet-667	38	24	.	.	PROPN
admet-667	38	25	shaik	shaik	PROPN
admet-667	38	26	,	,	PUNCT
admet-667	38	27	t.	t.	PROPN
admet-667	38	28	bohnert	bohnert	NOUN
admet-667	38	29	,	,	PUNCT
admet-667	38	30	d.a	d.a	PROPN
admet-667	38	31	.	.	PROPN
admet-667	38	32	williams	williams	PROPN
admet-667	38	33	,	,	PUNCT
admet-667	38	34	l.l	l.l	PROPN
admet-667	38	35	.	.	PROPN
admet-667	38	36	gan	gan	PROPN
admet-667	38	37	,	,	PUNCT
admet-667	38	38	b.w	b.w	PROPN
admet-667	38	39	.	.	PROPN
admet-667	38	40	leduc	leduc	PROPN
admet-667	38	41	.	.	PUNCT
admet-667	38	42	mechanism	mechanism	NOUN
admet-667	38	43	of	of	ADP
admet-667	38	44	drug	drug	NOUN
admet-667	38	45	-	-	PUNCT
admet-667	38	46	drug	drug	NOUN
admet-667	38	47	interactions	interaction	NOUN
admet-667	38	48	between	between	ADP
admet-667	38	49	warfarin	warfarin	NOUN
admet-667	38	50	and	and	CCONJ
admet-667	38	51	statins	statin	NOUN
admet-667	38	52	.	.	PUNCT
admet-667	39	1	journal	journal	NOUN
admet-667	39	2	of	of	ADP
admet-667	39	3	pharmaceutical	pharmaceutical	PROPN
admet-667	39	4	sciences	science	NOUN
admet-667	39	5	105	105	NUM
admet-667	39	6	(	(	PUNCT
admet-667	39	7	2016	2016	NUM
admet-667	39	8	)	)	PUNCT
admet-667	39	9	1976	1976	NUM
admet-667	39	10	-	-	SYM
admet-667	39	11	1986	1986	NUM
admet-667	39	12	.	.	PUNCT
admet-667	40	1	[	[	X
admet-667	40	2	4	4	X
admet-667	40	3	]	]	PUNCT
admet-667	40	4	s.	s.	PROPN
admet-667	40	5	basu	basu	PROPN
admet-667	40	6	,	,	PUNCT
admet-667	40	7	a.n	a.n	PROPN
admet-667	40	8	.	.	PROPN
admet-667	40	9	shaik	shaik	PROPN
admet-667	40	10	.	.	PUNCT
admet-667	41	1	role	role	NOUN
admet-667	41	2	of	of	ADP
admet-667	41	3	drug	drug	NOUN
admet-667	41	4	transporters	transporter	NOUN
admet-667	41	5	in	in	ADP
admet-667	41	6	drug	drug	NOUN
admet-667	41	7	development	development	NOUN
admet-667	41	8	:	:	PUNCT
admet-667	41	9	a	a	DET
admet-667	41	10	qualitative	qualitative	ADJ
admet-667	41	11	and	and	CCONJ
admet-667	41	12	quantitative	quantitative	ADJ
admet-667	41	13	approach	approach	NOUN
admet-667	41	14	.	.	PUNCT
admet-667	42	1	admet	admet	PROPN
admet-667	42	2	and	and	CCONJ
admet-667	42	3	dmpk	dmpk	X
admet-667	42	4	5	5	NUM
admet-667	42	5	(	(	PUNCT
admet-667	42	6	2017	2017	NUM
admet-667	42	7	)	)	PUNCT
admet-667	42	8	57	57	NUM
admet-667	42	9	-	-	SYM
admet-667	42	10	58	58	NUM
admet-667	42	11	.	.	PUNCT
admet-667	43	1	[	[	X
admet-667	43	2	5	5	X
admet-667	43	3	]	]	PUNCT
admet-667	43	4	s.	s.	PROPN
admet-667	43	5	grandoni	grandoni	PROPN
admet-667	43	6	,	,	PUNCT
admet-667	43	7	n.	n.	NOUN
admet-667	43	8	cesari	cesari	PROPN
admet-667	43	9	,	,	PUNCT
admet-667	43	10	g.	g.	PROPN
admet-667	43	11	brogin	brogin	PROPN
admet-667	43	12	,	,	PUNCT
admet-667	43	13	p.	p.	NOUN
admet-667	43	14	puccini	puccini	PROPN
admet-667	43	15	,	,	PUNCT
admet-667	43	16	p.	p.	PROPN
admet-667	43	17	magni	magni	PROPN
admet-667	43	18	.	.	PUNCT
admet-667	44	1	building	build	VERB
admet-667	44	2	in	in	ADP
admet-667	44	3	-	-	PUNCT
admet-667	44	4	house	house	NOUN
admet-667	44	5	pbpk	pbpk	NOUN
admet-667	44	6	modelling	model	VERB
admet-667	44	7	tools	tool	NOUN
admet-667	44	8	for	for	ADP
admet-667	44	9	oral	oral	ADJ
admet-667	44	10	drug	drug	NOUN
admet-667	44	11	administration	administration	NOUN
admet-667	44	12	from	from	ADP
admet-667	44	13	literature	literature	PROPN
admet-667	44	14	information	information	NOUN
admet-667	44	15	.	.	PUNCT
admet-667	45	1	admet	admet	PROPN
admet-667	45	2	and	and	CCONJ
admet-667	45	3	dmpk	dmpk	VERB
admet-667	45	4	7	7	NUM
admet-667	45	5	(	(	PUNCT
admet-667	45	6	2019	2019	NUM
admet-667	45	7	)	)	PUNCT
admet-667	45	8	4	4	NUM
admet-667	45	9	-	-	SYM
admet-667	45	10	21	21	NUM
admet-667	45	11	.	.	PUNCT
admet-667	46	1	[	[	X
admet-667	46	2	6	6	NUM
admet-667	46	3	]	]	PUNCT
admet-667	46	4	g.	g.	PROPN
admet-667	46	5	gao	gao	PROPN
admet-667	46	6	,	,	PUNCT
admet-667	46	7	f.c.p	f.c.p	PROPN
admet-667	46	8	.	.	PROPN
admet-667	46	9	law	law	NOUN
admet-667	46	10	,	,	PUNCT
admet-667	46	11	r.n.s	r.n.s	PROPN
admet-667	46	12	.	.	PUNCT
admet-667	46	13	wong	wong	PROPN
admet-667	46	14	,	,	PUNCT
admet-667	46	15	n.k	n.k	PROPN
admet-667	46	16	.	.	PROPN
admet-667	46	17	mak	mak	PROPN
admet-667	46	18	,	,	PUNCT
admet-667	46	19	m.s	m.s	PROPN
admet-667	46	20	.	.	PROPN
admet-667	46	21	yang	yang	PROPN
admet-667	46	22	.	.	PUNCT
admet-667	47	1	a	a	DET
admet-667	47	2	physiologically	physiologically	ADV
admet-667	47	3	based	base	VERB
admet-667	47	4	pharmacokinetic	pharmacokinetic	ADJ
admet-667	47	5	model	model	NOUN
admet-667	47	6	of	of	ADP
admet-667	47	7	oseltamivir	oseltamivir	PROPN
admet-667	47	8	phosphate	phosphate	VERB
admet-667	47	9	and	and	CCONJ
admet-667	47	10	its	its	PRON
admet-667	47	11	carboxylate	carboxylate	NOUN
admet-667	47	12	metabolite	metabolite	NOUN
admet-667	47	13	for	for	ADP
admet-667	47	14	rats	rat	NOUN
admet-667	47	15	and	and	CCONJ
admet-667	47	16	humans	human	NOUN
admet-667	47	17	.	.	PUNCT
admet-667	48	1	admet	admet	PROPN
admet-667	48	2	and	and	CCONJ
admet-667	48	3	dmpk	dmpk	VERB
admet-667	48	4	7	7	NUM
admet-667	48	5	(	(	PUNCT
admet-667	48	6	2019	2019	NUM
admet-667	48	7	)	)	PUNCT
admet-667	48	8	22	22	NUM
admet-667	48	9	-	-	SYM
admet-667	48	10	43	43	NUM
admet-667	48	11	.	.	PUNCT
admet-667	49	1	[	[	X
admet-667	49	2	7	7	NUM
admet-667	49	3	]	]	PUNCT
admet-667	49	4	a.	a.	NOUN
admet-667	49	5	savoca	savoca	PROPN
admet-667	49	6	,	,	PUNCT
admet-667	49	7	d.	d.	PROPN
admet-667	49	8	manca	manca	PROPN
admet-667	49	9	.	.	PUNCT
admet-667	50	1	physiologically	physiologically	ADV
admet-667	50	2	-	-	PUNCT
admet-667	50	3	based	base	VERB
admet-667	50	4	pharmacokinetic	pharmacokinetic	ADJ
admet-667	50	5	simulations	simulation	NOUN
admet-667	50	6	in	in	ADP
admet-667	50	7	pharmacotherapy	pharmacotherapy	NOUN
admet-667	50	8	:	:	PUNCT
admet-667	50	9	selection	selection	NOUN
admet-667	50	10	of	of	ADP
admet-667	50	11	the	the	DET
admet-667	50	12	optimal	optimal	ADJ
admet-667	50	13	administration	administration	NOUN
admet-667	50	14	route	route	NOUN
admet-667	50	15	for	for	ADP
admet-667	50	16	exogenous	exogenous	ADJ
admet-667	50	17	melatonin	melatonin	NOUN
admet-667	50	18	.	.	PUNCT
admet-667	51	1	admet	admet	PROPN
admet-667	51	2	and	and	CCONJ
admet-667	51	3	dmpk	dmpk	VERB
admet-667	51	4	7	7	NUM
admet-667	51	5	(	(	PUNCT
admet-667	51	6	2019	2019	NUM
admet-667	51	7	)	)	PUNCT
admet-667	51	8	44	44	NUM
admet-667	51	9	-	-	SYM
admet-667	51	10	59	59	NUM
admet-667	51	11	.	.	PUNCT
admet-667	52	1	[	[	X
admet-667	52	2	8	8	NUM
admet-667	52	3	]	]	X
admet-667	52	4	d.g	d.g	PROPN
admet-667	52	5	.	.	PROPN
admet-667	52	6	levitt	levitt	PROPN
admet-667	52	7	.	.	PUNCT
admet-667	53	1	pkquest	pkquest	PROPN
admet-667	53	2	:	:	PUNCT
admet-667	54	1	pbpk	pbpk	NOUN
admet-667	54	2	modelling	modelling	NOUN
admet-667	54	3	of	of	ADP
admet-667	54	4	highly	highly	ADV
admet-667	54	5	lipid	lipid	ADJ
admet-667	54	6	soluble	soluble	ADJ
admet-667	54	7	and	and	CCONJ
admet-667	54	8	extracellular	extracellular	ADJ
admet-667	54	9	solutes	solute	NOUN
admet-667	54	10	.	.	PUNCT
admet-667	55	1	admet	admet	PROPN
admet-667	55	2	and	and	CCONJ
admet-667	55	3	dmpk	dmpk	VERB
admet-667	55	4	7	7	NUM
admet-667	55	5	(	(	PUNCT
admet-667	55	6	2019	2019	NUM
admet-667	55	7	)	)	PUNCT
admet-667	55	8	60	60	NUM
admet-667	55	9	-	-	SYM
admet-667	55	10	75	75	NUM
admet-667	55	11	.	.	PUNCT
admet-667	56	1	©	©	SYM
admet-667	56	2	2019	2019	NUM
admet-667	56	3	by	by	ADP
admet-667	56	4	the	the	DET
admet-667	56	5	authors	author	NOUN
admet-667	56	6	;	;	PUNCT
admet-667	56	7	licensee	licensee	PROPN
admet-667	56	8	iapc	iapc	PROPN
admet-667	56	9	,	,	PUNCT
admet-667	56	10	zagreb	zagreb	PROPN
admet-667	56	11	,	,	PUNCT
admet-667	56	12	croatia	croatia	PROPN
admet-667	56	13	.	.	PUNCT
admet-667	57	1	this	this	DET
admet-667	57	2	article	article	NOUN
admet-667	57	3	is	be	AUX
admet-667	57	4	an	an	DET
admet-667	57	5	open	open	ADJ
admet-667	57	6	-	-	PUNCT
admet-667	57	7	access	access	NOUN
admet-667	57	8	article	article	NOUN
admet-667	57	9	distributed	distribute	VERB
admet-667	57	10	under	under	ADP
admet-667	57	11	the	the	DET
admet-667	57	12	terms	term	NOUN
admet-667	57	13	and	and	CCONJ
admet-667	57	14	conditions	condition	NOUN
admet-667	57	15	of	of	ADP
admet-667	57	16	the	the	DET
admet-667	57	17	creative	creative	ADJ
admet-667	57	18	commons	common	NOUN
admet-667	57	19	attribution	attribution	NOUN
admet-667	57	20	license	license	NOUN
admet-667	57	21	(	(	PUNCT
admet-667	57	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-667	57	23	)	)	PUNCT
admet-667	57	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN