id	sid	tid	token	lemma	pos
admet-686	1	1	perspectives	perspective	NOUN
admet-686	1	2	in	in	ADP
admet-686	1	3	solubility	solubility	NOUN
admet-686	1	4	measurement	measurement	NOUN
admet-686	1	5	and	and	CCONJ
admet-686	1	6	interpretation	interpretation	NOUN
admet-686	1	7	doi	doi	PROPN
admet-686	1	8	:	:	PUNCT
admet-686	1	9	10.5599	10.5599	NUM
admet-686	1	10	/	/	SYM
admet-686	1	11	admet.686	admet.686	PROPN
admet-686	1	12	88	88	NUM
admet-686	1	13	admet	admet	X
admet-686	1	14	&	&	CCONJ
admet-686	1	15	dmpk	dmpk	PROPN
admet-686	1	16	7(2	7(2	NUM
admet-686	1	17	)	)	PUNCT
admet-686	1	18	(	(	PUNCT
admet-686	1	19	2019	2019	NUM
admet-686	1	20	)	)	PUNCT
admet-686	1	21	88	88	NUM
admet-686	1	22	-	-	SYM
admet-686	1	23	105	105	NUM
admet-686	1	24	;	;	PUNCT
admet-686	1	25	doi	doi	NOUN
admet-686	1	26	:	:	PUNCT
admet-686	1	27	http://dx.doi.org/10.5599/admet.686	http://dx.doi.org/10.5599/admet.686	ADJ
admet-686	1	28	open	open	ADJ
admet-686	1	29	access	access	NOUN
admet-686	1	30	:	:	PUNCT
admet-686	1	31	issn	issn	PROPN
admet-686	1	32	:	:	PUNCT
admet-686	1	33	1848	1848	NUM
admet-686	1	34	-	-	SYM
admet-686	1	35	7718	7718	NUM
admet-686	1	36	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-686	1	37	review	review	NOUN
admet-686	1	38	perspectives	perspective	NOUN
admet-686	1	39	in	in	ADP
admet-686	1	40	solubility	solubility	NOUN
admet-686	1	41	measurement	measurement	NOUN
admet-686	1	42	and	and	CCONJ
admet-686	1	43	interpretation	interpretation	NOUN
admet-686	1	44	christel	christel	PROPN
admet-686	1	45	a.s	a.s	PROPN
admet-686	1	46	.	.	PROPN
admet-686	1	47	bergström1	bergström1	PROPN
admet-686	1	48	and	and	CCONJ
admet-686	1	49	alex	alex	PROPN
admet-686	1	50	avdeef	avdeef	PROPN
admet-686	1	51	2	2	NUM
admet-686	1	52	,	,	PUNCT
admet-686	1	53	*	*	PROPN
admet-686	1	54	1	1	NUM
admet-686	1	55	department	department	NOUN
admet-686	1	56	of	of	ADP
admet-686	1	57	pharmacy	pharmacy	NOUN
admet-686	1	58	,	,	PUNCT
admet-686	1	59	uppsala	uppsala	PROPN
admet-686	1	60	university	university	PROPN
admet-686	1	61	,	,	PUNCT
admet-686	1	62	bmc	bmc	PROPN
admet-686	1	63	p.o	p.o	PROPN
admet-686	1	64	.	.	PROPN
admet-686	1	65	box	box	PROPN
admet-686	1	66	580	580	NUM
admet-686	1	67	,	,	PUNCT
admet-686	1	68	se-751	se-751	PROPN
admet-686	1	69	23	23	NUM
admet-686	1	70	uppsala	uppsala	PROPN
admet-686	1	71	,	,	PUNCT
admet-686	1	72	sweden	sweden	NOUN
admet-686	1	73	2	2	NUM
admet-686	1	74	in	in	ADP
admet-686	1	75	-	-	PUNCT
admet-686	1	76	adme	adme	NOUN
admet-686	1	77	research	research	NOUN
admet-686	1	78	,	,	PUNCT
admet-686	1	79	1732	1732	NUM
admet-686	1	80	first	first	ADJ
admet-686	1	81	avenue	avenue	PROPN
admet-686	1	82	,	,	PUNCT
admet-686	1	83	#	#	SYM
admet-686	1	84	102	102	NUM
admet-686	1	85	,	,	PUNCT
admet-686	1	86	new	new	PROPN
admet-686	1	87	york	york	PROPN
admet-686	1	88	,	,	PUNCT
admet-686	1	89	ny	ny	PROPN
admet-686	1	90	10128	10128	NUM
admet-686	1	91	,	,	PUNCT
admet-686	1	92	usa	usa	PROPN
admet-686	1	93	*	*	PUNCT
admet-686	1	94	corresponding	correspond	VERB
admet-686	1	95	author	author	NOUN
admet-686	1	96	:	:	PUNCT
admet-686	1	97	e	e	NOUN
admet-686	1	98	-	-	NOUN
admet-686	1	99	mail	mail	NOUN
admet-686	1	100	:	:	PUNCT
admet-686	1	101	alex@in-adme.com	alex@in-adme.com	NOUN
admet-686	1	102	;	;	PUNCT
admet-686	1	103	tel	tel	PROPN
admet-686	1	104	.	.	PUNCT
admet-686	1	105	:	:	PUNCT
admet-686	2	1	+1	+1	PROPN
admet-686	2	2	-	-	PUNCT
admet-686	2	3	646	646	NUM
admet-686	2	4	-	-	PUNCT
admet-686	2	5	678	678	NUM
admet-686	2	6	-	-	SYM
admet-686	2	7	5713	5713	NUM
admet-686	2	8	orcid	orcid	NOUN
admet-686	3	1	i	i	NOUN
admet-686	3	2	d	d	PROPN
admet-686	3	3	:	:	PUNCT
admet-686	3	4	christel	christel	PROPN
admet-686	3	5	a.s	a.s	PROPN
admet-686	3	6	.	.	PROPN
admet-686	3	7	bergström	bergström	NOUN
admet-686	3	8	:	:	PUNCT
admet-686	3	9	0000	0000	NUM
admet-686	3	10	-	-	PUNCT
admet-686	3	11	0002	0002	NUM
admet-686	3	12	-	-	PUNCT
admet-686	3	13	8917	8917	NUM
admet-686	3	14	-	-	PUNCT
admet-686	3	15	2612	2612	NUM
admet-686	3	16	;	;	PUNCT
admet-686	3	17	alex	alex	PROPN
admet-686	3	18	avdeef	avdeef	PROPN
admet-686	3	19	:	:	PUNCT
admet-686	3	20	0000	0000	NUM
admet-686	3	21	-	-	PUNCT
admet-686	3	22	0002	0002	NUM
admet-686	3	23	-	-	PUNCT
admet-686	3	24	3139	3139	NUM
admet-686	3	25	-	-	PUNCT
admet-686	3	26	5442	5442	NUM
admet-686	3	27	received	receive	VERB
admet-686	3	28	:	:	PUNCT
admet-686	3	29	march	march	PROPN
admet-686	3	30	12	12	NUM
admet-686	3	31	,	,	PUNCT
admet-686	3	32	2019	2019	NUM
admet-686	3	33	;	;	PUNCT
admet-686	3	34	revised	revise	VERB
admet-686	3	35	:	:	PUNCT
admet-686	3	36	march	march	PROPN
admet-686	3	37	26	26	NUM
admet-686	3	38	,	,	PUNCT
admet-686	3	39	2019	2019	NUM
admet-686	3	40	;	;	PUNCT
admet-686	3	41	published	publish	VERB
admet-686	3	42	:	:	PUNCT
admet-686	3	43	april	april	PROPN
admet-686	3	44	05,2019	05,2019	NUM
admet-686	3	45	.	.	PUNCT
admet-686	4	1	abstract	abstract	ADJ
admet-686	4	2	several	several	ADJ
admet-686	4	3	key	key	ADJ
admet-686	4	4	topics	topic	NOUN
admet-686	4	5	in	in	ADP
admet-686	4	6	solubility	solubility	NOUN
admet-686	4	7	measurement	measurement	NOUN
admet-686	4	8	and	and	CCONJ
admet-686	4	9	interpretation	interpretation	NOUN
admet-686	4	10	are	be	AUX
admet-686	4	11	briefly	briefly	ADV
admet-686	4	12	summarized	summarize	VERB
admet-686	4	13	and	and	CCONJ
admet-686	4	14	illustrated	illustrate	VERB
admet-686	4	15	with	with	ADP
admet-686	4	16	case	case	NOUN
admet-686	4	17	studies	study	NOUN
admet-686	4	18	drawing	draw	VERB
admet-686	4	19	on	on	ADP
admet-686	4	20	published	publish	VERB
admet-686	4	21	solubility	solubility	NOUN
admet-686	4	22	determinations	determination	NOUN
admet-686	4	23	as	as	ADP
admet-686	4	24	a	a	DET
admet-686	4	25	function	function	NOUN
admet-686	4	26	of	of	ADP
admet-686	4	27	ph	ph	PROPN
admet-686	4	28	.	.	PROPN
admet-686	4	29	featured	feature	VERB
admet-686	4	30	are	be	AUX
admet-686	4	31	examples	example	NOUN
admet-686	4	32	of	of	ADP
admet-686	4	33	ionizable	ionizable	ADJ
admet-686	4	34	molecules	molecule	NOUN
admet-686	4	35	that	that	PRON
admet-686	4	36	exhibit	exhibit	VERB
admet-686	4	37	solubility	solubility	NOUN
admet-686	4	38	-	-	PUNCT
admet-686	4	39	ph	ph	NOUN
admet-686	4	40	curve	curve	NOUN
admet-686	4	41	distortion	distortion	NOUN
admet-686	4	42	from	from	ADP
admet-686	4	43	that	that	PRON
admet-686	4	44	predicted	predict	VERB
admet-686	4	45	by	by	ADP
admet-686	4	46	the	the	DET
admet-686	4	47	traditionally	traditionally	ADV
admet-686	4	48	used	use	VERB
admet-686	4	49	henderson	henderson	PROPN
admet-686	4	50	-	-	PUNCT
admet-686	4	51	hasselbalch	hasselbalch	PROPN
admet-686	4	52	equation	equation	NOUN
admet-686	4	53	and	and	CCONJ
admet-686	4	54	possible	possible	ADJ
admet-686	4	55	interpretations	interpretation	NOUN
admet-686	4	56	for	for	ADP
admet-686	4	57	these	these	DET
admet-686	4	58	distortions	distortion	NOUN
admet-686	4	59	are	be	AUX
admet-686	4	60	provided	provide	VERB
admet-686	4	61	.	.	PUNCT
admet-686	5	1	the	the	DET
admet-686	5	2	scope	scope	NOUN
admet-686	5	3	is	be	AUX
admet-686	5	4	not	not	PART
admet-686	5	5	exhaustive	exhaustive	ADJ
admet-686	5	6	;	;	PUNCT
admet-686	5	7	rather	rather	ADV
admet-686	5	8	it	it	PRON
admet-686	5	9	is	be	AUX
admet-686	5	10	focused	focus	VERB
admet-686	5	11	on	on	ADP
admet-686	5	12	detailed	detailed	ADJ
admet-686	5	13	descriptions	description	NOUN
admet-686	5	14	of	of	ADP
admet-686	5	15	a	a	DET
admet-686	5	16	few	few	ADJ
admet-686	5	17	cases	case	NOUN
admet-686	5	18	.	.	PUNCT
admet-686	6	1	topics	topic	NOUN
admet-686	6	2	discussed	discuss	VERB
admet-686	6	3	are	be	AUX
admet-686	6	4	limitations	limitation	NOUN
admet-686	6	5	of	of	ADP
admet-686	6	6	kinetic	kinetic	ADJ
admet-686	6	7	solubility	solubility	NOUN
admet-686	6	8	,	,	PUNCT
admet-686	6	9	‘	'	PUNCT
admet-686	6	10	brick	brick	NOUN
admet-686	6	11	-	-	PUNCT
admet-686	6	12	dust	dust	NOUN
admet-686	6	13	and	and	CCONJ
admet-686	6	14	grease	grease	NOUN
admet-686	6	15	-	-	PUNCT
admet-686	6	16	balls	ball	NOUN
admet-686	6	17	,	,	PUNCT
admet-686	6	18	’	'	PUNCT
admet-686	6	19	applications	application	NOUN
admet-686	6	20	of	of	ADP
admet-686	6	21	simulated	simulated	ADJ
admet-686	6	22	and	and	CCONJ
admet-686	6	23	human	human	ADJ
admet-686	6	24	intestinal	intestinal	ADJ
admet-686	6	25	fluids	fluid	NOUN
admet-686	6	26	,	,	PUNCT
admet-686	6	27	supersaturation	supersaturation	NOUN
admet-686	6	28	and	and	CCONJ
admet-686	6	29	the	the	DET
admet-686	6	30	relevance	relevance	NOUN
admet-686	6	31	of	of	ADP
admet-686	6	32	pre	pre	ADJ
admet-686	6	33	-	-	ADJ
admet-686	6	34	nucleation	nucleation	ADJ
admet-686	6	35	clusters	cluster	NOUN
admet-686	6	36	and	and	CCONJ
admet-686	6	37	sub	sub	ADJ
admet-686	6	38	-	-	ADJ
admet-686	6	39	micellar	micellar	ADJ
admet-686	6	40	aggregates	aggregate	NOUN
admet-686	6	41	in	in	ADP
admet-686	6	42	the	the	DET
admet-686	6	43	formation	formation	NOUN
admet-686	6	44	of	of	ADP
admet-686	6	45	solids	solid	NOUN
admet-686	6	46	,	,	PUNCT
admet-686	6	47	drug	drug	NOUN
admet-686	6	48	-	-	PUNCT
admet-686	6	49	buffer	buffer	NOUN
admet-686	6	50	/	/	SYM
admet-686	6	51	excipient	excipient	ADJ
admet-686	6	52	complexation	complexation	NOUN
admet-686	6	53	,	,	PUNCT
admet-686	6	54	hydrotropic	hydrotropic	NOUN
admet-686	6	55	solubilization	solubilization	NOUN
admet-686	6	56	,	,	PUNCT
admet-686	6	57	acid	acid	NOUN
admet-686	6	58	-	-	PUNCT
admet-686	6	59	base	base	NOUN
admet-686	6	60	‘	'	PUNCT
admet-686	6	61	supersolubilization	supersolubilization	NOUN
admet-686	6	62	,	,	PUNCT
admet-686	6	63	’	'	PUNCT
admet-686	6	64	cocrystal	cocrystal	ADJ
admet-686	6	65	route	route	NOUN
admet-686	6	66	to	to	PART
admet-686	6	67	supersaturation	supersaturation	NOUN
admet-686	6	68	,	,	PUNCT
admet-686	6	69	as	as	ADV
admet-686	6	70	well	well	ADV
admet-686	6	71	as	as	ADP
admet-686	6	72	data	datum	NOUN
admet-686	6	73	quality	quality	NOUN
admet-686	6	74	assessment	assessment	NOUN
admet-686	6	75	and	and	CCONJ
admet-686	6	76	solubility	solubility	NOUN
admet-686	6	77	prediction	prediction	NOUN
admet-686	6	78	.	.	PUNCT
admet-686	7	1	the	the	DET
admet-686	7	2	goal	goal	NOUN
admet-686	7	3	is	be	AUX
admet-686	7	4	to	to	PART
admet-686	7	5	highlight	highlight	VERB
admet-686	7	6	principles	principle	NOUN
admet-686	7	7	of	of	ADP
admet-686	7	8	solution	solution	NOUN
admet-686	7	9	equilibria	equilibrium	NOUN
admet-686	7	10	–	–	PUNCT
admet-686	7	11	graphically	graphically	ADV
admet-686	7	12	more	more	ADV
admet-686	7	13	than	than	ADP
admet-686	7	14	mathematically	mathematically	ADV
admet-686	7	15	–	–	PUNCT
admet-686	7	16	that	that	PRON
admet-686	7	17	could	could	AUX
admet-686	7	18	invite	invite	VERB
admet-686	7	19	better	well	ADJ
admet-686	7	20	assay	assay	NOUN
admet-686	7	21	design	design	NOUN
admet-686	7	22	,	,	PUNCT
admet-686	7	23	to	to	PART
admet-686	7	24	result	result	VERB
admet-686	7	25	in	in	ADP
admet-686	7	26	improved	improved	ADJ
admet-686	7	27	quality	quality	NOUN
admet-686	7	28	of	of	ADP
admet-686	7	29	measurements	measurement	NOUN
admet-686	7	30	,	,	PUNCT
admet-686	7	31	and	and	CCONJ
admet-686	7	32	to	to	PART
admet-686	7	33	impart	impart	VERB
admet-686	7	34	a	a	DET
admet-686	7	35	deeper	deep	ADJ
admet-686	7	36	understanding	understanding	NOUN
admet-686	7	37	of	of	ADP
admet-686	7	38	the	the	DET
admet-686	7	39	underlying	underlying	ADJ
admet-686	7	40	solution	solution	NOUN
admet-686	7	41	chemistry	chemistry	NOUN
admet-686	7	42	in	in	ADP
admet-686	7	43	suspensions	suspension	NOUN
admet-686	7	44	of	of	ADP
admet-686	7	45	drug	drug	NOUN
admet-686	7	46	solids	solid	NOUN
admet-686	7	47	.	.	PUNCT
admet-686	8	1	the	the	DET
admet-686	8	2	value	value	NOUN
admet-686	8	3	of	of	ADP
admet-686	8	4	solid	solid	ADJ
admet-686	8	5	state	state	NOUN
admet-686	8	6	characterizations	characterization	NOUN
admet-686	8	7	is	be	AUX
admet-686	8	8	stressed	stress	VERB
admet-686	8	9	but	but	CCONJ
admet-686	8	10	not	not	PART
admet-686	8	11	covered	cover	VERB
admet-686	8	12	explicitly	explicitly	ADV
admet-686	8	13	in	in	ADP
admet-686	8	14	this	this	DET
admet-686	8	15	mini	mini	NOUN
admet-686	8	16	-	-	NOUN
admet-686	8	17	review	review	NOUN
admet-686	8	18	.	.	PUNCT
admet-686	9	1	keywords	keyword	VERB
admet-686	9	2	solubility	solubility	NOUN
admet-686	9	3	-	-	PUNCT
admet-686	9	4	ph	ph	VERB
admet-686	9	5	;	;	PUNCT
admet-686	9	6	shake	shake	NOUN
admet-686	9	7	-	-	PUNCT
admet-686	9	8	flask	flask	NOUN
admet-686	9	9	solubility	solubility	NOUN
admet-686	9	10	;	;	PUNCT
admet-686	9	11	intrinsic	intrinsic	ADJ
admet-686	9	12	solubility	solubility	NOUN
admet-686	9	13	;	;	PUNCT
admet-686	9	14	thermodynamic	thermodynamic	ADJ
admet-686	9	15	solubility	solubility	NOUN
admet-686	9	16	;	;	PUNCT
admet-686	9	17	henderson	henderson	PROPN
admet-686	9	18	-	-	PUNCT
admet-686	9	19	hasselbalch	hasselbalch	PROPN
admet-686	9	20	equation	equation	NOUN
admet-686	9	21	;	;	PUNCT
admet-686	9	22	supersaturation	supersaturation	NOUN
admet-686	9	23	;	;	PUNCT
admet-686	9	24	pre	pre	ADJ
admet-686	9	25	-	-	ADJ
admet-686	9	26	nucleation	nucleation	ADJ
admet-686	9	27	clusters	cluster	NOUN
admet-686	9	28	,	,	PUNCT
admet-686	9	29	drug	drug	NOUN
admet-686	9	30	aggregates	aggregate	NOUN
admet-686	9	31	;	;	PUNCT
admet-686	9	32	drug	drug	NOUN
admet-686	9	33	salts	salt	NOUN
admet-686	9	34	;	;	PUNCT
admet-686	9	35	pharmaceutical	pharmaceutical	ADJ
admet-686	9	36	cocrystals	cocrystal	NOUN
admet-686	9	37	introduction	introduction	NOUN
admet-686	9	38	for	for	ADP
admet-686	9	39	many	many	ADJ
admet-686	9	40	oral	oral	ADJ
admet-686	9	41	drugs	drug	NOUN
admet-686	9	42	,	,	PUNCT
admet-686	9	43	the	the	DET
admet-686	9	44	rate	rate	NOUN
admet-686	9	45	-	-	PUNCT
admet-686	9	46	limiting	limit	VERB
admet-686	9	47	step	step	NOUN
admet-686	9	48	in	in	ADP
admet-686	9	49	intestinal	intestinal	ADJ
admet-686	9	50	absorption	absorption	NOUN
admet-686	9	51	is	be	AUX
admet-686	9	52	dictated	dictate	VERB
admet-686	9	53	by	by	ADP
admet-686	9	54	the	the	DET
admet-686	9	55	kinetics	kinetic	NOUN
admet-686	9	56	of	of	ADP
admet-686	9	57	dissolution	dissolution	NOUN
admet-686	9	58	of	of	ADP
admet-686	9	59	the	the	DET
admet-686	9	60	active	active	ADJ
admet-686	9	61	pharmaceutical	pharmaceutical	ADJ
admet-686	9	62	ingredient	ingredient	NOUN
admet-686	9	63	from	from	ADP
admet-686	9	64	the	the	DET
admet-686	9	65	solid	solid	ADJ
admet-686	9	66	form	form	NOUN
admet-686	9	67	.	.	PUNCT
admet-686	10	1	the	the	DET
admet-686	10	2	dissolution	dissolution	NOUN
admet-686	10	3	rate	rate	NOUN
admet-686	10	4	is	be	AUX
admet-686	10	5	a	a	DET
admet-686	10	6	function	function	NOUN
admet-686	10	7	of	of	ADP
admet-686	10	8	a	a	DET
admet-686	10	9	number	number	NOUN
admet-686	10	10	of	of	ADP
admet-686	10	11	factors	factor	NOUN
admet-686	10	12	,	,	PUNCT
admet-686	10	13	foremost	foremost	ADV
admet-686	10	14	being	be	AUX
admet-686	10	15	the	the	DET
admet-686	10	16	aqueous	aqueous	ADJ
admet-686	10	17	solubility	solubility	NOUN
admet-686	10	18	of	of	ADP
admet-686	10	19	the	the	DET
admet-686	10	20	drug	drug	NOUN
admet-686	10	21	,	,	PUNCT
admet-686	10	22	which	which	PRON
admet-686	10	23	,	,	PUNCT
admet-686	10	24	for	for	ADP
admet-686	10	25	ionizable	ionizable	ADJ
admet-686	10	26	molecules	molecule	NOUN
admet-686	10	27	,	,	PUNCT
admet-686	10	28	can	can	AUX
admet-686	10	29	be	be	AUX
admet-686	10	30	affected	affect	VERB
admet-686	10	31	by	by	ADP
admet-686	10	32	the	the	DET
admet-686	10	33	ph	ph	NOUN
admet-686	10	34	of	of	ADP
admet-686	10	35	the	the	DET
admet-686	10	36	medium	medium	NOUN
admet-686	10	37	[	[	X
admet-686	10	38	1	1	NUM
admet-686	10	39	]	]	PUNCT
admet-686	10	40	.	.	PUNCT
admet-686	11	1	also	also	ADV
admet-686	11	2	,	,	PUNCT
admet-686	11	3	depending	depend	VERB
admet-686	11	4	on	on	ADP
admet-686	11	5	the	the	DET
admet-686	11	6	drug	drug	NOUN
admet-686	11	7	that	that	PRON
admet-686	11	8	has	have	AUX
admet-686	11	9	been	be	AUX
admet-686	11	10	introduced	introduce	VERB
admet-686	11	11	,	,	PUNCT
admet-686	11	12	the	the	DET
admet-686	11	13	dissolution	dissolution	NOUN
admet-686	11	14	may	may	AUX
admet-686	11	15	overshoot	overshoot	VERB
admet-686	11	16	the	the	DET
admet-686	11	17	saturation	saturation	NOUN
admet-686	11	18	concentration	concentration	NOUN
admet-686	11	19	and	and	CCONJ
admet-686	11	20	produce	produce	VERB
admet-686	11	21	a	a	DET
admet-686	11	22	supersaturated	supersaturated	ADJ
admet-686	11	23	solution	solution	NOUN
admet-686	11	24	.	.	PUNCT
admet-686	12	1	the	the	DET
admet-686	12	2	supersaturation	supersaturation	NOUN
admet-686	12	3	is	be	AUX
admet-686	12	4	typically	typically	ADV
admet-686	12	5	achieved	achieve	VERB
admet-686	12	6	when	when	SCONJ
admet-686	12	7	the	the	DET
admet-686	12	8	api	api	NOUN
admet-686	12	9	is	be	AUX
admet-686	12	10	introduced	introduce	VERB
admet-686	12	11	in	in	ADP
admet-686	12	12	its	its	PRON
admet-686	12	13	amorphous	amorphous	ADJ
admet-686	12	14	form	form	NOUN
admet-686	12	15	or	or	CCONJ
admet-686	12	16	in	in	ADP
admet-686	12	17	a	a	DET
admet-686	12	18	charged	charge	VERB
admet-686	12	19	form	form	NOUN
admet-686	12	20	as	as	ADP
admet-686	12	21	a	a	DET
admet-686	12	22	salt	salt	NOUN
admet-686	12	23	.	.	PUNCT
admet-686	13	1	in	in	ADP
admet-686	13	2	such	such	DET
admet-686	13	3	a	a	DET
admet-686	13	4	supersaturated	supersaturated	ADJ
admet-686	13	5	solution	solution	NOUN
admet-686	13	6	,	,	PUNCT
admet-686	13	7	drug	drug	NOUN
admet-686	13	8	molecules	molecule	NOUN
admet-686	13	9	may	may	AUX
admet-686	13	10	self	self	NOUN
admet-686	13	11	-	-	PUNCT
admet-686	13	12	associate	associate	NOUN
admet-686	13	13	as	as	ADP
admet-686	13	14	sub	sub	ADJ
admet-686	13	15	-	-	ADJ
admet-686	13	16	micellar	micellar	ADJ
admet-686	13	17	aggregates	aggregate	NOUN
admet-686	13	18	/	/	SYM
admet-686	13	19	clusters	cluster	NOUN
admet-686	13	20	,	,	PUNCT
admet-686	13	21	particularly	particularly	ADV
admet-686	13	22	if	if	SCONJ
admet-686	13	23	they	they	PRON
admet-686	13	24	are	be	AUX
admet-686	13	25	surface	surface	NOUN
admet-686	13	26	-	-	PUNCT
admet-686	13	27	active	active	ADJ
admet-686	13	28	or	or	CCONJ
admet-686	13	29	polarizable	polarizable	ADJ
admet-686	13	30	.	.	PUNCT
admet-686	14	1	for	for	ADP
admet-686	14	2	bases	basis	NOUN
admet-686	14	3	introduced	introduce	VERB
admet-686	14	4	as	as	ADP
admet-686	14	5	drug	drug	NOUN
admet-686	14	6	salts	salt	NOUN
admet-686	14	7	into	into	ADP
admet-686	14	8	an	an	DET
admet-686	14	9	alkaline	alkaline	NOUN
admet-686	14	10	-	-	PUNCT
admet-686	14	11	ph	ph	NOUN
admet-686	14	12	solution	solution	NOUN
admet-686	14	13	,	,	PUNCT
admet-686	14	14	the	the	DET
admet-686	14	15	charged	charge	VERB
admet-686	14	16	drug	drug	NOUN
admet-686	14	17	in	in	ADP
admet-686	14	18	the	the	DET
admet-686	14	19	supersaturated	supersaturated	ADJ
admet-686	14	20	solution	solution	NOUN
admet-686	14	21	can	can	AUX
admet-686	14	22	disproportionate	disproportionate	VERB
admet-686	14	23	into	into	ADP
admet-686	14	24	oil	oil	NOUN
admet-686	14	25	or	or	CCONJ
admet-686	14	26	undergo	undergo	VERB
admet-686	14	27	precipitation	precipitation	NOUN
admet-686	14	28	into	into	ADP
admet-686	14	29	a	a	DET
admet-686	14	30	new	new	ADJ
admet-686	14	31	amorphous	amorphous	ADJ
admet-686	14	32	solid	solid	NOUN
admet-686	14	33	,	,	PUNCT
admet-686	14	34	with	with	ADP
admet-686	14	35	which	which	PRON
admet-686	14	36	charged	charge	VERB
admet-686	14	37	water	water	NOUN
admet-686	14	38	-	-	PUNCT
admet-686	14	39	soluble	soluble	ADJ
admet-686	14	40	aggregates	aggregate	NOUN
admet-686	14	41	may	may	AUX
admet-686	14	42	coexist	coexist	VERB
admet-686	14	43	.	.	PUNCT
admet-686	15	1	given	give	VERB
admet-686	15	2	enough	enough	ADJ
admet-686	15	3	time	time	NOUN
admet-686	15	4	,	,	PUNCT
admet-686	15	5	the	the	DET
admet-686	15	6	oil	oil	NOUN
admet-686	15	7	or	or	CCONJ
admet-686	15	8	amorphous	amorphous	ADJ
admet-686	15	9	solid	solid	ADJ
admet-686	15	10	(	(	PUNCT
admet-686	15	11	and	and	CCONJ
admet-686	15	12	any	any	DET
admet-686	15	13	other	other	ADJ
admet-686	15	14	type	type	NOUN
admet-686	15	15	of	of	ADP
admet-686	15	16	aggregates	aggregate	NOUN
admet-686	15	17	)	)	PUNCT
admet-686	15	18	are	be	AUX
admet-686	15	19	expected	expect	VERB
admet-686	15	20	to	to	PART
admet-686	15	21	undergo	undergo	VERB
admet-686	15	22	phase	phase	NOUN
admet-686	15	23	transformation	transformation	NOUN
admet-686	15	24	into	into	ADP
admet-686	15	25	a	a	DET
admet-686	15	26	thermodynamically	thermodynamically	ADV
admet-686	15	27	more	more	ADV
admet-686	15	28	stable	stable	ADJ
admet-686	15	29	crystalline	crystalline	NOUN
admet-686	15	30	solid	solid	NOUN
admet-686	15	31	,	,	PUNCT
admet-686	15	32	the	the	DET
admet-686	15	33	steps	step	NOUN
admet-686	15	34	governed	govern	VERB
admet-686	15	35	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-686	15	36	mailto:alex@in-adme.com	mailto:alex@in-adme.com	PROPN
admet-686	15	37	admet	admet	PROPN
admet-686	15	38	&	&	CCONJ
admet-686	15	39	dmpk	dmpk	PROPN
admet-686	15	40	7(2	7(2	NUM
admet-686	15	41	)	)	PUNCT
admet-686	15	42	(	(	PUNCT
admet-686	15	43	2019	2019	NUM
admet-686	15	44	)	)	PUNCT
admet-686	15	45	88	88	NUM
admet-686	15	46	-	-	SYM
admet-686	15	47	105	105	NUM
admet-686	15	48	perspectives	perspective	NOUN
admet-686	15	49	in	in	ADP
admet-686	15	50	solubility	solubility	NOUN
admet-686	15	51	measurements	measurement	NOUN
admet-686	15	52	and	and	CCONJ
admet-686	15	53	interpretation	interpretation	NOUN
admet-686	15	54	doi	doi	PROPN
admet-686	15	55	:	:	PUNCT
admet-686	15	56	10.5599	10.5599	NUM
admet-686	15	57	/	/	SYM
admet-686	15	58	admet.686	admet.686	PRON
admet-686	15	59	89	89	NUM
admet-686	15	60	by	by	ADP
admet-686	15	61	kinetics	kinetic	NOUN
admet-686	15	62	of	of	ADP
admet-686	15	63	nucleation	nucleation	NOUN
admet-686	15	64	and	and	CCONJ
admet-686	15	65	crystal	crystal	NOUN
admet-686	15	66	growth	growth	NOUN
admet-686	15	67	.	.	PUNCT
admet-686	16	1	for	for	ADP
admet-686	16	2	drugs	drug	NOUN
admet-686	16	3	that	that	PRON
admet-686	16	4	are	be	AUX
admet-686	16	5	practically	practically	ADV
admet-686	16	6	insoluble	insoluble	ADJ
admet-686	16	7	in	in	ADP
admet-686	16	8	water	water	NOUN
admet-686	16	9	,	,	PUNCT
admet-686	16	10	dissolution	dissolution	NOUN
admet-686	16	11	and	and	CCONJ
admet-686	16	12	re	re	NOUN
admet-686	16	13	-	-	NOUN
admet-686	16	14	crystallization	crystallization	NOUN
admet-686	16	15	can	can	AUX
admet-686	16	16	be	be	AUX
admet-686	16	17	particularly	particularly	ADV
admet-686	16	18	complicated	complicated	ADJ
admet-686	16	19	kinetic	kinetic	ADJ
admet-686	16	20	processes	process	NOUN
admet-686	16	21	occurring	occur	VERB
admet-686	16	22	at	at	ADP
admet-686	16	23	different	different	ADJ
admet-686	16	24	interfaces	interface	NOUN
admet-686	16	25	of	of	ADP
admet-686	16	26	,	,	PUNCT
admet-686	16	27	e.g.	e.g.	ADV
admet-686	16	28	,	,	PUNCT
admet-686	16	29	undissolved	undissolved	ADJ
admet-686	16	30	api	api	NOUN
admet-686	16	31	or	or	CCONJ
admet-686	16	32	colloidal	colloidal	NOUN
admet-686	16	33	structures	structure	NOUN
admet-686	16	34	composed	compose	VERB
admet-686	16	35	of	of	ADP
admet-686	16	36	excipients	excipient	NOUN
admet-686	16	37	.	.	PUNCT
admet-686	17	1	aggregation	aggregation	NOUN
admet-686	17	2	and	and	CCONJ
admet-686	17	3	recrystallization	recrystallization	NOUN
admet-686	17	4	are	be	AUX
admet-686	17	5	to	to	ADP
admet-686	17	6	date	date	NOUN
admet-686	17	7	not	not	PART
admet-686	17	8	fully	fully	ADV
admet-686	17	9	understood	understand	VERB
admet-686	17	10	and	and	CCONJ
admet-686	17	11	hence	hence	ADV
admet-686	17	12	may	may	AUX
admet-686	17	13	be	be	AUX
admet-686	17	14	difficult	difficult	ADJ
admet-686	17	15	to	to	PART
admet-686	17	16	predict	predict	VERB
admet-686	17	17	.	.	PUNCT
admet-686	18	1	about	about	ADV
admet-686	18	2	two	two	NUM
admet-686	18	3	-	-	PUNCT
admet-686	18	4	thirds	third	NOUN
admet-686	18	5	of	of	ADP
admet-686	18	6	the	the	DET
admet-686	18	7	compounds	compound	NOUN
admet-686	18	8	in	in	ADP
admet-686	18	9	the	the	DET
admet-686	18	10	drug	drug	NOUN
admet-686	18	11	discovery	discovery	NOUN
admet-686	18	12	pipeline	pipeline	NOUN
admet-686	18	13	are	be	AUX
admet-686	18	14	very	very	ADV
admet-686	18	15	poorly	poorly	ADV
admet-686	18	16	soluble	soluble	ADJ
admet-686	18	17	in	in	ADP
admet-686	18	18	water	water	NOUN
admet-686	18	19	,	,	PUNCT
admet-686	18	20	and	and	CCONJ
admet-686	18	21	therefore	therefore	ADV
admet-686	18	22	show	show	VERB
admet-686	18	23	low	low	ADJ
admet-686	18	24	and/or	and/or	CCONJ
admet-686	18	25	erratic	erratic	ADJ
admet-686	18	26	intestinal	intestinal	ADJ
admet-686	18	27	absorption	absorption	NOUN
admet-686	18	28	.	.	PUNCT
admet-686	19	1	to	to	PART
admet-686	19	2	increase	increase	VERB
admet-686	19	3	solubility	solubility	NOUN
admet-686	19	4	(	(	PUNCT
admet-686	19	5	and	and	CCONJ
admet-686	19	6	thus	thus	ADV
admet-686	19	7	absorption	absorption	NOUN
admet-686	19	8	)	)	PUNCT
admet-686	19	9	,	,	PUNCT
admet-686	19	10	oral	oral	ADJ
admet-686	19	11	drugs	drug	NOUN
admet-686	19	12	are	be	AUX
admet-686	19	13	often	often	ADV
admet-686	19	14	formulated	formulate	VERB
admet-686	19	15	as	as	ADP
admet-686	19	16	salts	salt	NOUN
admet-686	19	17	.	.	PUNCT
admet-686	20	1	however	however	ADV
admet-686	20	2	,	,	PUNCT
admet-686	20	3	there	there	PRON
admet-686	20	4	are	be	VERB
admet-686	20	5	numerous	numerous	ADJ
admet-686	20	6	other	other	ADJ
admet-686	20	7	strategies	strategy	NOUN
admet-686	20	8	which	which	PRON
admet-686	20	9	have	have	AUX
admet-686	20	10	been	be	AUX
admet-686	20	11	successfully	successfully	ADV
admet-686	20	12	implemented	implement	VERB
admet-686	20	13	[	[	PUNCT
admet-686	20	14	2,3	2,3	NUM
admet-686	20	15	]	]	PUNCT
admet-686	20	16	.	.	PUNCT
admet-686	21	1	several	several	ADJ
admet-686	21	2	aspects	aspect	NOUN
admet-686	21	3	of	of	ADP
admet-686	21	4	the	the	DET
admet-686	21	5	above	above	ADJ
admet-686	21	6	complexity	complexity	NOUN
admet-686	21	7	are	be	AUX
admet-686	21	8	summarized	summarize	VERB
admet-686	21	9	in	in	ADP
admet-686	21	10	this	this	DET
admet-686	21	11	mini	mini	NOUN
admet-686	21	12	-	-	NOUN
admet-686	21	13	review	review	NOUN
admet-686	21	14	.	.	PUNCT
admet-686	22	1	it	it	PRON
admet-686	22	2	is	be	AUX
admet-686	22	3	intended	intend	VERB
admet-686	22	4	to	to	PART
admet-686	22	5	serve	serve	VERB
admet-686	22	6	as	as	ADP
admet-686	22	7	prologue	prologue	NOUN
admet-686	22	8	or	or	CCONJ
admet-686	22	9	accompaniment	accompaniment	NOUN
admet-686	22	10	to	to	ADP
admet-686	22	11	an	an	DET
admet-686	22	12	upcoming	upcoming	ADJ
admet-686	22	13	session	session	NOUN
admet-686	22	14	on	on	ADP
admet-686	22	15	solubility	solubility	NOUN
admet-686	22	16	at	at	ADP
admet-686	22	17	the	the	DET
admet-686	22	18	iapc-8	iapc-8	NUM
admet-686	22	19	meeting	meeting	NOUN
admet-686	22	20	in	in	ADP
admet-686	22	21	split	split	NOUN
admet-686	22	22	,	,	PUNCT
admet-686	22	23	croatia	croatia	PROPN
admet-686	22	24	,	,	PUNCT
admet-686	22	25	911	911	NUM
admet-686	22	26	september	september	PROPN
admet-686	22	27	2019	2019	NUM
admet-686	22	28	,	,	PUNCT
admet-686	22	29	to	to	PART
admet-686	22	30	be	be	AUX
admet-686	22	31	co	co	VERB
admet-686	22	32	-	-	VERB
admet-686	22	33	chaired	chair	VERB
admet-686	22	34	by	by	ADP
admet-686	22	35	the	the	DET
admet-686	22	36	authors	author	NOUN
admet-686	22	37	.	.	PUNCT
admet-686	23	1	since	since	SCONJ
admet-686	23	2	2009	2009	NUM
admet-686	23	3	,	,	PUNCT
admet-686	23	4	the	the	DET
admet-686	23	5	international	international	ADJ
admet-686	23	6	association	association	NOUN
admet-686	23	7	of	of	ADP
admet-686	23	8	physical	physical	ADJ
admet-686	23	9	chemists	chemist	NOUN
admet-686	23	10	(	(	PUNCT
admet-686	23	11	iapc	iapc	PROPN
admet-686	23	12	,	,	PUNCT
admet-686	23	13	www.iapchem.org	www.iapchem.org	PROPN
admet-686	23	14	)	)	PUNCT
admet-686	23	15	series	series	NOUN
admet-686	23	16	of	of	ADP
admet-686	23	17	symposia	symposia	NOUN
admet-686	23	18	maintained	maintain	VERB
admet-686	23	19	extensive	extensive	ADJ
admet-686	23	20	coverage	coverage	NOUN
admet-686	23	21	of	of	ADP
admet-686	23	22	the	the	DET
admet-686	23	23	topic	topic	NOUN
admet-686	23	24	of	of	ADP
admet-686	23	25	solubility	solubility	NOUN
admet-686	23	26	measurement	measurement	NOUN
admet-686	23	27	,	,	PUNCT
admet-686	23	28	both	both	CCONJ
admet-686	23	29	from	from	ADP
admet-686	23	30	solid	solid	ADJ
admet-686	23	31	state	state	NOUN
admet-686	23	32	and	and	CCONJ
admet-686	23	33	solution	solution	NOUN
admet-686	23	34	perspectives	perspective	NOUN
admet-686	23	35	.	.	PUNCT
admet-686	24	1	at	at	ADP
admet-686	24	2	the	the	DET
admet-686	24	3	2015	2015	NUM
admet-686	24	4	iapc-4	iapc-4	NUM
admet-686	24	5	meeting	meeting	NOUN
admet-686	24	6	,	,	PUNCT
admet-686	24	7	the	the	DET
admet-686	24	8	“	"	PUNCT
admet-686	24	9	thermodynamic	thermodynamic	ADJ
admet-686	24	10	solubility	solubility	NOUN
admet-686	24	11	measurement	measurement	NOUN
admet-686	24	12	of	of	ADP
admet-686	24	13	practically	practically	ADV
admet-686	24	14	insoluble	insoluble	ADJ
admet-686	24	15	ionizable	ionizable	ADJ
admet-686	24	16	drugs	drug	NOUN
admet-686	24	17	case	case	NOUN
admet-686	24	18	studies	study	NOUN
admet-686	24	19	&	&	CCONJ
admet-686	24	20	suggested	suggest	VERB
admet-686	24	21	method	method	NOUN
admet-686	24	22	improvements	improvement	NOUN
admet-686	24	23	”	"	PUNCT
admet-686	24	24	special	special	ADJ
admet-686	24	25	session	session	NOUN
admet-686	24	26	resulted	result	VERB
admet-686	24	27	in	in	ADP
admet-686	24	28	a	a	DET
admet-686	24	29	‘	'	PUNCT
admet-686	24	30	white	white	ADJ
admet-686	24	31	paper	paper	NOUN
admet-686	24	32	’	'	PUNCT
admet-686	24	33	publication	publication	NOUN
admet-686	24	34	drawing	draw	VERB
admet-686	24	35	on	on	ADP
admet-686	24	36	expert	expert	ADJ
admet-686	24	37	consensus	consensus	NOUN
admet-686	24	38	thoughts	thought	NOUN
admet-686	24	39	of	of	ADP
admet-686	24	40	researchers	researcher	NOUN
admet-686	24	41	from	from	ADP
admet-686	24	42	six	six	NUM
admet-686	24	43	countries	country	NOUN
admet-686	24	44	(	(	PUNCT
admet-686	24	45	hungary	hungary	PROPN
admet-686	24	46	,	,	PUNCT
admet-686	24	47	russia	russia	PROPN
admet-686	24	48	,	,	PUNCT
admet-686	24	49	serbia	serbia	PROPN
admet-686	24	50	,	,	PUNCT
admet-686	24	51	spain	spain	PROPN
admet-686	24	52	,	,	PUNCT
admet-686	24	53	sweden	sweden	PROPN
admet-686	24	54	,	,	PUNCT
admet-686	24	55	united	united	PROPN
admet-686	24	56	states	states	PROPN
admet-686	24	57	)	)	PUNCT
admet-686	25	1	[	[	X
admet-686	25	2	4	4	NUM
admet-686	25	3	]	]	PUNCT
admet-686	25	4	.	.	PUNCT
admet-686	26	1	at	at	ADP
admet-686	26	2	the	the	DET
admet-686	26	3	2017	2017	NUM
admet-686	26	4	iapc-6	iapc-6	NUM
admet-686	26	5	meeting	meeting	NOUN
admet-686	26	6	,	,	PUNCT
admet-686	26	7	the	the	DET
admet-686	26	8	“	"	PUNCT
admet-686	26	9	pharmaceutical	pharmaceutical	ADJ
admet-686	26	10	cocrystals	cocrystal	NOUN
admet-686	26	11	-physicochemical	-physicochemical	ADJ
admet-686	26	12	properties	property	NOUN
admet-686	26	13	and	and	CCONJ
admet-686	26	14	formulations	formulation	NOUN
admet-686	26	15	”	"	PUNCT
admet-686	26	16	special	special	ADJ
admet-686	26	17	session	session	NOUN
admet-686	26	18	included	include	VERB
admet-686	26	19	presentations	presentation	NOUN
admet-686	26	20	from	from	ADP
admet-686	26	21	internationally	internationally	ADV
admet-686	26	22	-	-	PUNCT
admet-686	26	23	recognized	recognize	VERB
admet-686	26	24	experts	expert	NOUN
admet-686	26	25	in	in	ADP
admet-686	26	26	cocrystal	cocrystal	ADJ
admet-686	26	27	solubility	solubility	NOUN
admet-686	26	28	-	-	PUNCT
admet-686	26	29	ph	ph	ADJ
admet-686	26	30	measurement	measurement	NOUN
admet-686	26	31	.	.	PUNCT
admet-686	27	1	several	several	ADJ
admet-686	27	2	publications	publication	NOUN
admet-686	27	3	on	on	ADP
admet-686	27	4	the	the	DET
admet-686	27	5	topic	topic	NOUN
admet-686	27	6	emerged	emerge	VERB
admet-686	27	7	out	out	ADP
admet-686	27	8	of	of	ADP
admet-686	27	9	the	the	DET
admet-686	27	10	meeting	meeting	NOUN
admet-686	27	11	.	.	PUNCT
admet-686	28	1	it	it	PRON
admet-686	28	2	is	be	AUX
admet-686	28	3	anticipated	anticipate	VERB
admet-686	28	4	that	that	SCONJ
admet-686	28	5	future	future	ADJ
admet-686	28	6	sessions	session	NOUN
admet-686	28	7	will	will	AUX
admet-686	28	8	continue	continue	VERB
admet-686	28	9	to	to	PART
admet-686	28	10	cover	cover	VERB
admet-686	28	11	solubility	solubility	NOUN
admet-686	28	12	methods	method	NOUN
admet-686	28	13	and	and	CCONJ
admet-686	28	14	strategies	strategy	NOUN
admet-686	28	15	,	,	PUNCT
admet-686	28	16	to	to	PART
admet-686	28	17	critically	critically	ADV
admet-686	28	18	address	address	VERB
admet-686	28	19	the	the	DET
admet-686	28	20	different	different	ADJ
admet-686	28	21	needs	need	NOUN
admet-686	28	22	in	in	ADP
admet-686	28	23	pharmaceutical	pharmaceutical	ADJ
admet-686	28	24	research	research	NOUN
admet-686	28	25	,	,	PUNCT
admet-686	28	26	spanning	span	VERB
admet-686	28	27	from	from	ADP
admet-686	28	28	drug	drug	NOUN
admet-686	28	29	discovery	discovery	NOUN
admet-686	28	30	to	to	ADP
admet-686	28	31	drug	drug	NOUN
admet-686	28	32	development	development	NOUN
admet-686	28	33	.	.	PUNCT
admet-686	29	1	brief	brief	ADJ
admet-686	29	2	survey	survey	NOUN
admet-686	29	3	of	of	ADP
admet-686	29	4	topics	topic	NOUN
admet-686	29	5	in	in	ADP
admet-686	29	6	solubility	solubility	NOUN
admet-686	29	7	several	several	ADJ
admet-686	29	8	key	key	ADJ
admet-686	29	9	topics	topic	NOUN
admet-686	29	10	are	be	AUX
admet-686	29	11	briefly	briefly	ADV
admet-686	29	12	summarized	summarize	VERB
admet-686	29	13	below	below	ADV
admet-686	29	14	and	and	CCONJ
admet-686	29	15	are	be	AUX
admet-686	29	16	illustrated	illustrate	VERB
admet-686	29	17	with	with	ADP
admet-686	29	18	case	case	NOUN
admet-686	29	19	studies	study	NOUN
admet-686	29	20	drawing	draw	VERB
admet-686	29	21	on	on	ADP
admet-686	29	22	solubility	solubility	NOUN
admet-686	29	23	determinations	determination	NOUN
admet-686	29	24	as	as	ADP
admet-686	29	25	a	a	DET
admet-686	29	26	function	function	NOUN
admet-686	29	27	of	of	ADP
admet-686	29	28	ph	ph	ADJ
admet-686	29	29	.	.	PROPN
admet-686	29	30	significant	significant	ADJ
admet-686	29	31	effort	effort	NOUN
admet-686	29	32	was	be	AUX
admet-686	29	33	made	make	VERB
admet-686	29	34	to	to	PART
admet-686	29	35	find	find	VERB
admet-686	29	36	useful	useful	ADJ
admet-686	29	37	examples	example	NOUN
admet-686	29	38	from	from	ADP
admet-686	29	39	the	the	DET
admet-686	29	40	published	publish	VERB
admet-686	29	41	literature	literature	NOUN
admet-686	29	42	which	which	PRON
admet-686	29	43	illustrated	illustrate	VERB
admet-686	29	44	principles	principle	NOUN
admet-686	29	45	of	of	ADP
admet-686	29	46	solution	solution	NOUN
admet-686	29	47	equilibria	equilibrium	NOUN
admet-686	29	48	.	.	PUNCT
admet-686	30	1	the	the	DET
admet-686	30	2	coverage	coverage	NOUN
admet-686	30	3	is	be	AUX
admet-686	30	4	not	not	PART
admet-686	30	5	exhaustive	exhaustive	ADJ
admet-686	30	6	,	,	PUNCT
admet-686	30	7	but	but	CCONJ
admet-686	30	8	is	be	AUX
admet-686	30	9	considerable	considerable	ADJ
admet-686	30	10	in	in	ADP
admet-686	30	11	some	some	DET
admet-686	30	12	cases	case	NOUN
admet-686	30	13	,	,	PUNCT
admet-686	30	14	to	to	PART
admet-686	30	15	address	address	VERB
admet-686	30	16	issues	issue	NOUN
admet-686	30	17	of	of	ADP
admet-686	30	18	measurement	measurement	NOUN
admet-686	30	19	and	and	CCONJ
admet-686	30	20	interpretation	interpretation	NOUN
admet-686	30	21	of	of	ADP
admet-686	30	22	ph	ph	ADJ
admet-686	30	23	dependency	dependency	NOUN
admet-686	30	24	in	in	ADP
admet-686	30	25	solubility	solubility	NOUN
admet-686	30	26	profiles	profile	NOUN
admet-686	30	27	.	.	PUNCT
admet-686	31	1	the	the	DET
admet-686	31	2	value	value	NOUN
admet-686	31	3	of	of	ADP
admet-686	31	4	solid	solid	ADJ
admet-686	31	5	state	state	NOUN
admet-686	31	6	characterizations	characterization	NOUN
admet-686	31	7	is	be	AUX
admet-686	31	8	stressed	stress	VERB
admet-686	31	9	but	but	CCONJ
admet-686	31	10	not	not	PART
admet-686	31	11	covered	cover	VERB
admet-686	31	12	explicitly	explicitly	ADV
admet-686	31	13	in	in	ADP
admet-686	31	14	this	this	DET
admet-686	31	15	mini	mini	NOUN
admet-686	31	16	-	-	NOUN
admet-686	31	17	review	review	NOUN
admet-686	31	18	.	.	PUNCT
admet-686	32	1	kinetic	kinetic	ADJ
admet-686	32	2	or	or	CCONJ
admet-686	32	3	thermodynamic	thermodynamic	ADJ
admet-686	32	4	?	?	PUNCT
admet-686	33	1	it	it	PRON
admet-686	33	2	’s	’s	AUX
admet-686	33	3	been	be	AUX
admet-686	33	4	more	more	ADJ
admet-686	33	5	than	than	ADP
admet-686	33	6	two	two	NUM
admet-686	33	7	decades	decade	NOUN
admet-686	33	8	since	since	SCONJ
admet-686	33	9	lipinski	lipinski	PROPN
admet-686	33	10	’s	’s	PART
admet-686	33	11	rule	rule	NOUN
admet-686	33	12	of	of	ADP
admet-686	33	13	5	5	NUM
admet-686	33	14	was	be	AUX
admet-686	33	15	published	publish	VERB
admet-686	33	16	[	[	PUNCT
admet-686	33	17	5	5	NUM
admet-686	33	18	]	]	PUNCT
admet-686	33	19	,	,	PUNCT
admet-686	33	20	addressing	address	VERB
admet-686	33	21	the	the	DET
admet-686	33	22	problems	problem	NOUN
admet-686	33	23	of	of	ADP
admet-686	33	24	poorly	poorly	ADV
admet-686	33	25	soluble	soluble	ADJ
admet-686	33	26	compounds	compound	NOUN
admet-686	33	27	.	.	PUNCT
admet-686	34	1	high	high	ADJ
admet-686	34	2	-	-	PUNCT
admet-686	34	3	throughput	throughput	NOUN
admet-686	34	4	microtitre	microtitre	NOUN
admet-686	34	5	plate	plate	NOUN
admet-686	34	6	methods	method	NOUN
admet-686	34	7	for	for	ADP
admet-686	34	8	determining	determine	VERB
admet-686	34	9	‘	'	PUNCT
admet-686	34	10	kinetic	kinetic	ADJ
admet-686	34	11	’	'	PUNCT
admet-686	34	12	solubility	solubility	NOUN
admet-686	34	13	based	base	VERB
admet-686	34	14	on	on	ADP
admet-686	34	15	turbidity	turbidity	NOUN
admet-686	34	16	detection	detection	NOUN
admet-686	34	17	became	become	VERB
admet-686	34	18	very	very	ADV
admet-686	34	19	popular	popular	ADJ
admet-686	34	20	.	.	PUNCT
admet-686	35	1	usually	usually	ADV
admet-686	35	2	,	,	PUNCT
admet-686	35	3	a	a	DET
admet-686	35	4	dmso	dmso	ADJ
admet-686	35	5	solution	solution	NOUN
admet-686	35	6	of	of	ADP
admet-686	35	7	the	the	DET
admet-686	35	8	drug	drug	NOUN
admet-686	35	9	is	be	AUX
admet-686	35	10	added	add	VERB
admet-686	35	11	gradually	gradually	ADV
admet-686	35	12	to	to	ADP
admet-686	35	13	an	an	DET
admet-686	35	14	aqueous	aqueous	ADJ
admet-686	35	15	buffer	buffer	NOUN
admet-686	35	16	,	,	PUNCT
admet-686	35	17	until	until	SCONJ
admet-686	35	18	the	the	DET
admet-686	35	19	first	first	ADJ
admet-686	35	20	signs	sign	NOUN
admet-686	35	21	of	of	ADP
admet-686	35	22	solid	solid	ADJ
admet-686	35	23	formation	formation	NOUN
admet-686	35	24	are	be	AUX
admet-686	35	25	detected	detect	VERB
admet-686	35	26	.	.	PUNCT
admet-686	36	1	the	the	DET
admet-686	36	2	resultant	resultant	NOUN
admet-686	36	3	precipitate	precipitate	NOUN
admet-686	36	4	is	be	AUX
admet-686	36	5	most	most	ADV
admet-686	36	6	often	often	ADV
admet-686	36	7	amorphous	amorphous	ADJ
admet-686	36	8	,	,	PUNCT
admet-686	36	9	up	up	ADP
admet-686	36	10	to	to	ADP
admet-686	36	11	a	a	DET
admet-686	36	12	hundred	hundred	NUM
admet-686	36	13	times	time	NOUN
admet-686	36	14	more	more	ADV
admet-686	36	15	soluble	soluble	ADJ
admet-686	36	16	than	than	ADP
admet-686	36	17	that	that	PRON
admet-686	36	18	measured	measure	VERB
admet-686	36	19	by	by	ADP
admet-686	36	20	conventional	conventional	ADJ
admet-686	36	21	‘	'	PUNCT
admet-686	36	22	thermodynamic	thermodynamic	ADJ
admet-686	36	23	’	'	PUNCT
admet-686	36	24	(	(	PUNCT
admet-686	36	25	slow	slow	VERB
admet-686	36	26	-	-	PUNCT
admet-686	36	27	to	to	ADP
admet-686	36	28	-	-	PUNCT
admet-686	36	29	medium	medium	NOUN
admet-686	36	30	throughput	throughput	NOUN
admet-686	36	31	)	)	PUNCT
admet-686	36	32	methods	method	NOUN
admet-686	36	33	.	.	PUNCT
admet-686	37	1	pharmaceutical	pharmaceutical	NOUN
admet-686	37	2	company	company	NOUN
admet-686	37	3	databases	database	NOUN
admet-686	37	4	mostly	mostly	ADV
admet-686	37	5	contain	contain	VERB
admet-686	37	6	kinetic	kinetic	ADJ
admet-686	37	7	values	value	NOUN
admet-686	37	8	.	.	PUNCT
admet-686	38	1	gradually	gradually	ADV
admet-686	38	2	,	,	PUNCT
admet-686	38	3	it	it	PRON
admet-686	38	4	became	become	VERB
admet-686	38	5	evident	evident	ADJ
admet-686	38	6	that	that	SCONJ
admet-686	38	7	placing	place	VERB
admet-686	38	8	heavy	heavy	ADJ
admet-686	38	9	focus	focus	NOUN
admet-686	38	10	on	on	ADP
admet-686	38	11	using	use	VERB
admet-686	38	12	kinetic	kinetic	ADJ
admet-686	38	13	data	datum	NOUN
admet-686	38	14	could	could	AUX
admet-686	38	15	drive	drive	VERB
admet-686	38	16	the	the	DET
admet-686	38	17	lead	lead	NOUN
admet-686	38	18	-	-	PUNCT
admet-686	38	19	to	to	ADP
admet-686	38	20	-	-	PUNCT
admet-686	38	21	candidate	candidate	NOUN
admet-686	38	22	optimization	optimization	NOUN
admet-686	38	23	process	process	NOUN
admet-686	38	24	in	in	ADP
admet-686	38	25	the	the	DET
admet-686	38	26	wrong	wrong	ADJ
admet-686	38	27	direction	direction	NOUN
admet-686	38	28	:	:	PUNCT
admet-686	38	29	towards	towards	ADP
admet-686	38	30	making	make	VERB
admet-686	38	31	more	more	ADJ
admet-686	38	32	amorphoustending	amorphoustende	VERB
admet-686	38	33	compounds	compound	NOUN
admet-686	38	34	,	,	PUNCT
admet-686	38	35	generating	generate	VERB
admet-686	38	36	problems	problem	NOUN
admet-686	38	37	later	later	ADV
admet-686	38	38	on	on	ADV
admet-686	38	39	in	in	ADP
admet-686	38	40	development	development	NOUN
admet-686	38	41	[	[	X
admet-686	38	42	6	6	NUM
admet-686	38	43	-	-	SYM
admet-686	38	44	8	8	NUM
admet-686	38	45	]	]	PUNCT
admet-686	38	46	.	.	PUNCT
admet-686	39	1	limitations	limitation	NOUN
admet-686	39	2	of	of	ADP
admet-686	39	3	these	these	DET
admet-686	39	4	early	early	ADJ
admet-686	39	5	methods	method	NOUN
admet-686	39	6	can	can	AUX
admet-686	39	7	lead	lead	VERB
admet-686	39	8	to	to	ADP
admet-686	39	9	misconceptions	misconception	NOUN
admet-686	39	10	and	and	CCONJ
admet-686	39	11	promote	promote	VERB
admet-686	39	12	the	the	DET
admet-686	39	13	lack	lack	NOUN
admet-686	39	14	of	of	ADP
admet-686	39	15	understanding	understanding	NOUN
admet-686	39	16	of	of	ADP
admet-686	39	17	solubility	solubility	NOUN
admet-686	39	18	data	datum	NOUN
admet-686	39	19	[	[	X
admet-686	39	20	7	7	NUM
admet-686	39	21	]	]	PUNCT
admet-686	39	22	.	.	PUNCT
admet-686	40	1	one	one	NUM
admet-686	40	2	way	way	NOUN
admet-686	40	3	to	to	PART
admet-686	40	4	mitigate	mitigate	VERB
admet-686	40	5	some	some	PRON
admet-686	40	6	of	of	ADP
admet-686	40	7	the	the	DET
admet-686	40	8	development	development	NOUN
admet-686	40	9	-	-	PUNCT
admet-686	40	10	stage	stage	NOUN
admet-686	40	11	risks	risk	NOUN
admet-686	40	12	is	be	AUX
admet-686	40	13	to	to	PART
admet-686	40	14	implement	implement	VERB
admet-686	40	15	‘	'	PUNCT
admet-686	40	16	miniaturized	miniaturized	ADJ
admet-686	40	17	’	'	PUNCT
admet-686	40	18	solubility	solubility	NOUN
admet-686	40	19	methods	method	NOUN
admet-686	40	20	(	(	PUNCT
admet-686	40	21	which	which	PRON
admet-686	40	22	can	can	AUX
admet-686	40	23	produce	produce	VERB
admet-686	40	24	values	value	NOUN
admet-686	40	25	closer	close	ADV
admet-686	40	26	to	to	ADP
admet-686	40	27	those	those	PRON
admet-686	40	28	of	of	ADP
admet-686	40	29	shake	shake	NOUN
admet-686	40	30	-	-	PUNCT
admet-686	40	31	flask	flask	NOUN
admet-686	40	32	thermodynamic	thermodynamic	ADJ
admet-686	40	33	measurements	measurement	NOUN
admet-686	40	34	)	)	PUNCT
admet-686	40	35	,	,	PUNCT
admet-686	40	36	brought	bring	VERB
admet-686	40	37	forward	forward	ADV
admet-686	40	38	alongside	alongside	ADP
admet-686	40	39	potency	potency	NOUN
admet-686	40	40	assessments	assessment	NOUN
admet-686	40	41	[	[	X
admet-686	40	42	9	9	NUM
admet-686	40	43	]	]	PUNCT
admet-686	40	44	.	.	PUNCT
admet-686	41	1	this	this	PRON
admet-686	41	2	is	be	AUX
admet-686	41	3	not	not	PART
admet-686	41	4	necessarily	necessarily	ADV
admet-686	41	5	easy	easy	ADJ
admet-686	41	6	to	to	PART
admet-686	41	7	do	do	VERB
admet-686	41	8	due	due	ADP
admet-686	41	9	to	to	ADP
admet-686	41	10	the	the	DET
admet-686	41	11	inherently	inherently	ADV
admet-686	41	12	higher	high	ADJ
admet-686	41	13	costs	cost	NOUN
admet-686	41	14	of	of	ADP
admet-686	41	15	measurement	measurement	NOUN
admet-686	41	16	,	,	PUNCT
admet-686	41	17	particularly	particularly	ADV
admet-686	41	18	when	when	SCONJ
admet-686	41	19	directed	direct	VERB
admet-686	41	20	at	at	ADP
admet-686	41	21	large	large	ADJ
admet-686	41	22	compound	compound	NOUN
admet-686	41	23	libraries	library	NOUN
admet-686	41	24	[	[	X
admet-686	41	25	10	10	NUM
admet-686	41	26	]	]	PUNCT
admet-686	41	27	.	.	PUNCT
admet-686	42	1	also	also	ADV
admet-686	42	2	,	,	PUNCT
admet-686	42	3	such	such	ADJ
admet-686	42	4	implementation	implementation	NOUN
admet-686	42	5	requires	require	VERB
admet-686	42	6	some	some	DET
admet-686	42	7	understanding	understanding	NOUN
admet-686	42	8	of	of	ADP
admet-686	42	9	solubility	solubility	NOUN
admet-686	42	10	-	-	PUNCT
admet-686	42	11	ph	ph	ADJ
admet-686	42	12	relationships	relationship	NOUN
admet-686	42	13	.	.	PUNCT
admet-686	43	1	http://www.iapchem.org/	http://www.iapchem.org/	PROPN
admet-686	43	2	bergström	bergström	NOUN
admet-686	43	3	and	and	CCONJ
admet-686	43	4	avdeef	avdeef	PROPN
admet-686	43	5	admet	admet	PROPN
admet-686	43	6	&	&	CCONJ
admet-686	43	7	dmpk	dmpk	PROPN
admet-686	43	8	7(2	7(2	NUM
admet-686	43	9	)	)	PUNCT
admet-686	43	10	(	(	PUNCT
admet-686	43	11	2019	2019	NUM
admet-686	43	12	)	)	PUNCT
admet-686	43	13	88	88	NUM
admet-686	43	14	-	-	SYM
admet-686	43	15	105	105	NUM
admet-686	43	16	90	90	NUM
admet-686	43	17	brick	brick	NOUN
admet-686	43	18	dust	dust	NOUN
admet-686	43	19	and	and	CCONJ
admet-686	43	20	grease	grease	NOUN
admet-686	43	21	balls	ball	NOUN
admet-686	43	22	low	low	ADJ
admet-686	43	23	-	-	PUNCT
admet-686	43	24	soluble	soluble	ADJ
admet-686	43	25	compounds	compound	NOUN
admet-686	43	26	are	be	AUX
admet-686	43	27	often	often	ADV
admet-686	43	28	colloquially	colloquially	ADV
admet-686	43	29	classified	classify	VERB
admet-686	43	30	as	as	ADP
admet-686	43	31	‘	'	PUNCT
admet-686	43	32	brick	brick	NOUN
admet-686	43	33	dust	dust	NOUN
admet-686	43	34	’	'	PUNCT
admet-686	43	35	or	or	CCONJ
admet-686	43	36	‘	'	PUNCT
admet-686	43	37	grease	grease	NOUN
admet-686	43	38	balls	ball	NOUN
admet-686	43	39	’	'	PUNCT
admet-686	44	1	[	[	X
admet-686	44	2	11	11	NUM
admet-686	44	3	]	]	PUNCT
admet-686	44	4	.	.	PUNCT
admet-686	45	1	the	the	DET
admet-686	45	2	solubility	solubility	NOUN
admet-686	45	3	of	of	ADP
admet-686	45	4	the	the	DET
admet-686	45	5	former	former	ADJ
admet-686	45	6	type	type	NOUN
admet-686	45	7	is	be	AUX
admet-686	45	8	mainly	mainly	ADV
admet-686	45	9	limited	limit	VERB
admet-686	45	10	by	by	ADP
admet-686	45	11	a	a	DET
admet-686	45	12	strong	strong	ADJ
admet-686	45	13	crystal	crystal	NOUN
admet-686	45	14	lattice	lattice	NOUN
admet-686	45	15	,	,	PUNCT
admet-686	45	16	making	make	VERB
admet-686	45	17	it	it	PRON
admet-686	45	18	difficult	difficult	ADJ
admet-686	45	19	for	for	SCONJ
admet-686	45	20	the	the	DET
admet-686	45	21	compound	compound	NOUN
admet-686	45	22	to	to	PART
admet-686	45	23	dissociate	dissociate	VERB
admet-686	45	24	from	from	ADP
admet-686	45	25	the	the	DET
admet-686	45	26	solid	solid	ADJ
admet-686	45	27	form	form	NOUN
admet-686	45	28	.	.	PUNCT
admet-686	46	1	such	such	ADJ
admet-686	46	2	‘	'	PUNCT
admet-686	46	3	brick	brick	NOUN
admet-686	46	4	dusts	dust	NOUN
admet-686	46	5	’	'	PUNCT
admet-686	46	6	are	be	AUX
admet-686	46	7	high	high	ADJ
admet-686	46	8	melting	melting	NOUN
admet-686	46	9	point	point	NOUN
admet-686	46	10	crystalline	crystalline	NOUN
admet-686	46	11	solids	solid	NOUN
admet-686	46	12	(	(	PUNCT
admet-686	46	13	tm	tm	NOUN
admet-686	46	14	>	>	X
admet-686	46	15	200	200	NUM
admet-686	46	16	°	°	NOUN
admet-686	46	17	c	c	NOUN
admet-686	46	18	)	)	PUNCT
admet-686	46	19	in	in	ADP
admet-686	46	20	which	which	PRON
admet-686	46	21	strong	strong	ADJ
admet-686	46	22	intermolecular	intermolecular	ADJ
admet-686	46	23	bonds	bond	NOUN
admet-686	46	24	within	within	ADP
admet-686	46	25	the	the	DET
admet-686	46	26	crystal	crystal	NOUN
admet-686	46	27	lattice	lattice	PROPN
admet-686	46	28	overcome	overcome	VERB
admet-686	46	29	the	the	DET
admet-686	46	30	competing	compete	VERB
admet-686	46	31	pull	pull	NOUN
admet-686	46	32	of	of	ADP
admet-686	46	33	solvation	solvation	NOUN
admet-686	46	34	by	by	ADP
admet-686	46	35	water	water	NOUN
admet-686	46	36	.	.	PUNCT
admet-686	47	1	in	in	ADP
admet-686	47	2	contrast	contrast	NOUN
admet-686	47	3	,	,	PUNCT
admet-686	47	4	the	the	DET
admet-686	47	5	‘	'	PUNCT
admet-686	47	6	grease	grease	NOUN
admet-686	47	7	ball	ball	NOUN
admet-686	47	8	’	'	PUNCT
admet-686	47	9	molecules	molecule	NOUN
admet-686	47	10	are	be	AUX
admet-686	47	11	limited	limit	VERB
admet-686	47	12	in	in	ADP
admet-686	47	13	their	their	PRON
admet-686	47	14	solubility	solubility	NOUN
admet-686	47	15	by	by	ADP
admet-686	47	16	poor	poor	ADJ
admet-686	47	17	hydration	hydration	NOUN
admet-686	47	18	.	.	PUNCT
admet-686	48	1	they	they	PRON
admet-686	48	2	typically	typically	ADV
admet-686	48	3	have	have	VERB
admet-686	48	4	high	high	ADJ
admet-686	48	5	octanol	octanol	NOUN
admet-686	48	6	-	-	PUNCT
admet-686	48	7	water	water	NOUN
admet-686	48	8	partition	partition	NOUN
admet-686	48	9	coefficients	coefficient	NOUN
admet-686	48	10	(	(	PUNCT
admet-686	48	11	log	log	VERB
admet-686	48	12	p	p	PROPN
admet-686	48	13	>	>	X
admet-686	48	14	3	3	NUM
admet-686	48	15	)	)	PUNCT
admet-686	48	16	,	,	PUNCT
admet-686	48	17	and	and	CCONJ
admet-686	48	18	are	be	AUX
admet-686	48	19	hydrophobic	hydrophobic	NOUN
admet-686	48	20	compounds	compound	NOUN
admet-686	48	21	that	that	PRON
admet-686	48	22	form	form	VERB
admet-686	48	23	relatively	relatively	ADV
admet-686	48	24	low	low	ADJ
admet-686	48	25	melting	melting	NOUN
admet-686	48	26	point	point	NOUN
admet-686	48	27	solids	solid	NOUN
admet-686	48	28	.	.	PUNCT
admet-686	49	1	these	these	DET
admet-686	49	2	compounds	compound	NOUN
admet-686	49	3	are	be	AUX
admet-686	49	4	unable	unable	ADJ
admet-686	49	5	to	to	PART
admet-686	49	6	form	form	VERB
admet-686	49	7	strong	strong	ADJ
admet-686	49	8	bonds	bond	NOUN
admet-686	49	9	with	with	ADP
admet-686	49	10	the	the	DET
admet-686	49	11	water	water	NOUN
admet-686	49	12	molecules	molecule	NOUN
admet-686	49	13	,	,	PUNCT
admet-686	49	14	and	and	CCONJ
admet-686	49	15	hence	hence	ADV
admet-686	49	16	exhibit	exhibit	VERB
admet-686	49	17	high	high	ADJ
admet-686	49	18	log	log	NOUN
admet-686	49	19	p	p	PROPN
admet-686	50	1	[	[	X
admet-686	50	2	12	12	NUM
admet-686	50	3	]	]	PUNCT
admet-686	50	4	.	.	PUNCT
admet-686	51	1	contemporary	contemporary	ADJ
admet-686	51	2	medicinal	medicinal	ADJ
admet-686	51	3	chemistry	chemistry	NOUN
admet-686	51	4	synthesizes	synthesize	VERB
admet-686	51	5	compounds	compound	NOUN
admet-686	51	6	as	as	ADP
admet-686	51	7	insoluble	insoluble	ADJ
admet-686	51	8	grease	grease	NOUN
admet-686	51	9	balls	ball	NOUN
admet-686	51	10	rather	rather	ADV
admet-686	51	11	than	than	ADP
admet-686	51	12	brick	brick	ADJ
admet-686	51	13	dust	dust	NOUN
admet-686	51	14	[	[	X
admet-686	51	15	8,12,13	8,12,13	NUM
admet-686	51	16	]	]	PUNCT
admet-686	51	17	.	.	PUNCT
admet-686	52	1	traditional	traditional	ADJ
admet-686	52	2	formulation	formulation	NOUN
admet-686	52	3	strategies	strategy	NOUN
admet-686	52	4	(	(	PUNCT
admet-686	52	5	excipients	excipient	NOUN
admet-686	52	6	,	,	PUNCT
admet-686	52	7	solubilizing	solubilize	VERB
admet-686	52	8	agents	agent	NOUN
admet-686	52	9	,	,	PUNCT
admet-686	52	10	cyclodextrins	cyclodextrin	NOUN
admet-686	52	11	,	,	PUNCT
admet-686	52	12	amorphous	amorphous	ADJ
admet-686	52	13	dispersions	dispersion	NOUN
admet-686	52	14	,	,	PUNCT
admet-686	52	15	etc	etc	X
admet-686	52	16	.	.	X
admet-686	52	17	)	)	PUNCT
admet-686	52	18	are	be	AUX
admet-686	52	19	likely	likely	ADJ
admet-686	52	20	to	to	PART
admet-686	52	21	improve	improve	VERB
admet-686	52	22	oral	oral	ADJ
admet-686	52	23	absorption	absorption	NOUN
admet-686	52	24	of	of	ADP
admet-686	52	25	grease	grease	NOUN
admet-686	52	26	balls	ball	NOUN
admet-686	52	27	,	,	PUNCT
admet-686	52	28	more	more	ADV
admet-686	52	29	so	so	ADV
admet-686	52	30	than	than	ADP
admet-686	52	31	that	that	PRON
admet-686	52	32	of	of	ADP
admet-686	52	33	brick	brick	NOUN
admet-686	52	34	dust	dust	NOUN
admet-686	52	35	[	[	X
admet-686	52	36	12	12	NUM
admet-686	52	37	]	]	PUNCT
admet-686	52	38	.	.	PUNCT
admet-686	53	1	one	one	PRON
admet-686	53	2	may	may	AUX
admet-686	53	3	also	also	ADV
admet-686	53	4	speculate	speculate	VERB
admet-686	53	5	that	that	SCONJ
admet-686	53	6	many	many	ADJ
admet-686	53	7	of	of	ADP
admet-686	53	8	the	the	DET
admet-686	53	9	‘	'	PUNCT
admet-686	53	10	brick	brick	ADJ
admet-686	53	11	dust	dust	NOUN
admet-686	53	12	’	'	PUNCT
admet-686	53	13	molecules	molecule	NOUN
admet-686	53	14	never	never	ADV
admet-686	53	15	reach	reach	VERB
admet-686	53	16	the	the	DET
admet-686	53	17	development	development	NOUN
admet-686	53	18	stage	stage	NOUN
admet-686	53	19	because	because	SCONJ
admet-686	53	20	they	they	PRON
admet-686	53	21	are	be	AUX
admet-686	53	22	too	too	ADV
admet-686	53	23	problematic	problematic	ADJ
admet-686	53	24	to	to	PART
admet-686	53	25	work	work	VERB
admet-686	53	26	with	with	ADP
admet-686	53	27	in	in	ADP
admet-686	53	28	assays	assay	NOUN
admet-686	53	29	(	(	PUNCT
admet-686	53	30	e.g.	e.g.	ADV
admet-686	53	31	,	,	PUNCT
admet-686	53	32	pharmacological	pharmacological	ADJ
admet-686	53	33	potency	potency	NOUN
admet-686	53	34	,	,	PUNCT
admet-686	53	35	toxicity	toxicity	NOUN
admet-686	53	36	and	and	CCONJ
admet-686	53	37	adme	adme	NOUN
admet-686	53	38	properties	property	NOUN
admet-686	53	39	)	)	PUNCT
admet-686	53	40	.	.	PUNCT
admet-686	54	1	hence	hence	ADV
admet-686	54	2	,	,	PUNCT
admet-686	54	3	they	they	PRON
admet-686	54	4	are	be	AUX
admet-686	54	5	screened	screen	VERB
admet-686	54	6	out	out	ADP
admet-686	54	7	early	early	ADV
admet-686	54	8	during	during	ADP
admet-686	54	9	the	the	DET
admet-686	54	10	discovery	discovery	NOUN
admet-686	54	11	stage	stage	NOUN
admet-686	54	12	.	.	PUNCT
admet-686	55	1	solubility	solubility	NOUN
admet-686	55	2	in	in	ADP
admet-686	55	3	simulated	simulated	ADJ
admet-686	55	4	and	and	CCONJ
admet-686	55	5	human	human	ADJ
admet-686	55	6	intestinal	intestinal	ADJ
admet-686	55	7	fluids	fluid	NOUN
admet-686	55	8	a	a	DET
admet-686	55	9	drug	drug	NOUN
admet-686	55	10	’s	’s	PART
admet-686	55	11	solubility	solubility	NOUN
admet-686	55	12	and	and	CCONJ
admet-686	55	13	dissolution	dissolution	NOUN
admet-686	55	14	behavior	behavior	NOUN
admet-686	55	15	can	can	AUX
admet-686	55	16	be	be	AUX
admet-686	55	17	investigated	investigate	VERB
admet-686	55	18	in	in	ADP
admet-686	55	19	human	human	ADJ
admet-686	55	20	intestinal	intestinal	ADJ
admet-686	55	21	fluid	fluid	NOUN
admet-686	55	22	(	(	PUNCT
admet-686	55	23	hif	hif	PROPN
admet-686	55	24	)	)	PUNCT
admet-686	55	25	,	,	PUNCT
admet-686	55	26	but	but	CCONJ
admet-686	55	27	such	such	ADJ
admet-686	55	28	media	medium	NOUN
admet-686	55	29	are	be	AUX
admet-686	55	30	difficult	difficult	ADJ
admet-686	55	31	to	to	PART
admet-686	55	32	obtain	obtain	VERB
admet-686	55	33	since	since	SCONJ
admet-686	55	34	they	they	PRON
admet-686	55	35	require	require	VERB
admet-686	55	36	in	in	ADP
admet-686	55	37	vivo	vivo	ADJ
admet-686	55	38	sampling	sampling	NOUN
admet-686	55	39	of	of	ADP
admet-686	55	40	the	the	DET
admet-686	55	41	fluid	fluid	NOUN
admet-686	55	42	.	.	PUNCT
admet-686	56	1	hif	hif	PROPN
admet-686	56	2	composition	composition	NOUN
admet-686	56	3	is	be	AUX
admet-686	56	4	also	also	ADV
admet-686	56	5	highly	highly	ADV
admet-686	56	6	variable	variable	ADJ
admet-686	56	7	[	[	X
admet-686	56	8	14	14	NUM
admet-686	56	9	]	]	PUNCT
admet-686	56	10	,	,	PUNCT
admet-686	56	11	both	both	PRON
admet-686	56	12	intraand	intraand	ADV
admet-686	56	13	inter	inter	ADJ
admet-686	56	14	-	-	ADJ
admet-686	56	15	individually	individually	ADV
admet-686	56	16	,	,	PUNCT
admet-686	56	17	and	and	CCONJ
admet-686	56	18	it	it	PRON
admet-686	56	19	is	be	AUX
admet-686	56	20	relatively	relatively	ADV
admet-686	56	21	difficult	difficult	ADJ
admet-686	56	22	to	to	PART
admet-686	56	23	work	work	VERB
admet-686	56	24	with	with	ADP
admet-686	56	25	on	on	ADP
admet-686	56	26	the	the	DET
admet-686	56	27	lab	lab	NOUN
admet-686	56	28	bench	bench	NOUN
admet-686	56	29	due	due	ADP
admet-686	56	30	to	to	ADP
admet-686	56	31	its	its	PRON
admet-686	56	32	low	low	ADJ
admet-686	56	33	buffer	buffer	NOUN
admet-686	56	34	capacity	capacity	NOUN
admet-686	56	35	.	.	PUNCT
admet-686	57	1	while	while	SCONJ
admet-686	57	2	the	the	DET
admet-686	57	3	variability	variability	NOUN
admet-686	57	4	is	be	AUX
admet-686	57	5	important	important	ADJ
admet-686	57	6	to	to	PART
admet-686	57	7	capture	capture	VERB
admet-686	57	8	to	to	PART
admet-686	57	9	understand	understand	VERB
admet-686	57	10	and	and	CCONJ
admet-686	57	11	predict	predict	VERB
admet-686	57	12	potential	potential	ADJ
admet-686	57	13	population	population	NOUN
admet-686	57	14	effects	effect	NOUN
admet-686	57	15	,	,	PUNCT
admet-686	57	16	this	this	DET
admet-686	57	17	complexity	complexity	NOUN
admet-686	57	18	also	also	ADV
admet-686	57	19	makes	make	VERB
admet-686	57	20	it	it	PRON
admet-686	57	21	more	more	ADV
admet-686	57	22	suitable	suitable	ADJ
admet-686	57	23	for	for	ADP
admet-686	57	24	later	later	ADJ
admet-686	57	25	stage	stage	NOUN
admet-686	57	26	studies	study	NOUN
admet-686	57	27	.	.	PUNCT
admet-686	58	1	the	the	DET
admet-686	58	2	development	development	NOUN
admet-686	58	3	of	of	ADP
admet-686	58	4	multiple	multiple	ADJ
admet-686	58	5	simulated	simulate	VERB
admet-686	58	6	intestinal	intestinal	ADJ
admet-686	58	7	fluid	fluid	NOUN
admet-686	58	8	(	(	PUNCT
admet-686	58	9	sif	sif	NOUN
admet-686	58	10	)	)	PUNCT
admet-686	58	11	recipes	recipe	NOUN
admet-686	58	12	(	(	PUNCT
admet-686	58	13	fassif	fassif	NOUN
admet-686	58	14	,	,	PUNCT
admet-686	58	15	fessif	fessif	INTJ
admet-686	58	16	,	,	PUNCT
admet-686	58	17	others	other	NOUN
admet-686	58	18	)	)	PUNCT
admet-686	58	19	applicable	applicable	ADJ
admet-686	58	20	to	to	ADP
admet-686	58	21	the	the	DET
admet-686	58	22	early	early	ADJ
admet-686	58	23	drug	drug	NOUN
admet-686	58	24	development	development	NOUN
admet-686	58	25	stage	stage	NOUN
admet-686	58	26	has	have	AUX
admet-686	58	27	therefore	therefore	ADV
admet-686	58	28	evolved	evolve	VERB
admet-686	58	29	[	[	X
admet-686	58	30	15	15	NUM
admet-686	58	31	]	]	PUNCT
admet-686	58	32	.	.	PUNCT
admet-686	59	1	a	a	DET
admet-686	59	2	recent	recent	ADJ
admet-686	59	3	study	study	NOUN
admet-686	59	4	by	by	ADP
admet-686	59	5	khadra	khadra	PROPN
admet-686	59	6	et	et	PROPN
admet-686	59	7	al	al	PROPN
admet-686	59	8	.	.	PUNCT
admet-686	60	1	[	[	X
admet-686	60	2	16	16	NUM
admet-686	60	3	]	]	PUNCT
admet-686	60	4	applied	apply	VERB
admet-686	60	5	a	a	DET
admet-686	60	6	mathematically	mathematically	ADV
admet-686	60	7	-	-	PUNCT
admet-686	60	8	rigorous	rigorous	ADJ
admet-686	60	9	design	design	NOUN
admet-686	60	10	-	-	PUNCT
admet-686	60	11	of	of	ADP
admet-686	60	12	-	-	PUNCT
admet-686	60	13	experiment	experiment	NOUN
admet-686	60	14	(	(	PUNCT
admet-686	60	15	doe	doe	NOUN
admet-686	60	16	)	)	PUNCT
admet-686	60	17	statistical	statistical	ADJ
admet-686	60	18	technique	technique	NOUN
admet-686	60	19	to	to	PART
admet-686	60	20	investigate	investigate	VERB
admet-686	60	21	how	how	SCONJ
admet-686	60	22	equilibrium	equilibrium	NOUN
admet-686	60	23	drug	drug	NOUN
admet-686	60	24	solubility	solubility	NOUN
admet-686	60	25	can	can	AUX
admet-686	60	26	be	be	AUX
admet-686	60	27	influenced	influence	VERB
admet-686	60	28	by	by	ADP
admet-686	60	29	seven	seven	NUM
admet-686	60	30	typical	typical	ADJ
admet-686	60	31	sif	sif	NOUN
admet-686	60	32	components	component	NOUN
admet-686	60	33	(	(	PUNCT
admet-686	60	34	sodium	sodium	NOUN
admet-686	60	35	taurocholate	taurocholate	NOUN
admet-686	60	36	,	,	PUNCT
admet-686	60	37	lecithin	lecithin	NOUN
admet-686	60	38	,	,	PUNCT
admet-686	60	39	sodium	sodium	NOUN
admet-686	60	40	phosphate	phosphate	NOUN
admet-686	60	41	,	,	PUNCT
admet-686	60	42	sodium	sodium	NOUN
admet-686	60	43	chloride	chloride	NOUN
admet-686	60	44	,	,	PUNCT
admet-686	60	45	ph	ph	VERB
admet-686	60	46	,	,	PUNCT
admet-686	60	47	pancreatin	pancreatin	ADJ
admet-686	60	48	and	and	CCONJ
admet-686	60	49	sodium	sodium	NOUN
admet-686	60	50	oleate	oleate	NOUN
admet-686	60	51	)	)	PUNCT
admet-686	60	52	within	within	ADP
admet-686	60	53	concentration	concentration	NOUN
admet-686	60	54	ranges	range	NOUN
admet-686	60	55	found	find	VERB
admet-686	60	56	in	in	ADP
admet-686	60	57	hif	hif	PROPN
admet-686	60	58	.	.	PUNCT
admet-686	60	59	poorly	poorly	ADV
admet-686	60	60	-	-	PUNCT
admet-686	60	61	soluble	soluble	ADJ
admet-686	60	62	acids	acid	NOUN
admet-686	60	63	(	(	PUNCT
admet-686	60	64	naproxen	naproxen	NOUN
admet-686	60	65	,	,	PUNCT
admet-686	60	66	indomethacin	indomethacin	NOUN
admet-686	60	67	,	,	PUNCT
admet-686	60	68	phenytoin	phenytoin	NOUN
admet-686	60	69	,	,	PUNCT
admet-686	60	70	and	and	CCONJ
admet-686	60	71	piroxicam	piroxicam	ADJ
admet-686	60	72	)	)	PUNCT
admet-686	60	73	,	,	PUNCT
admet-686	60	74	bases	basis	NOUN
admet-686	60	75	(	(	PUNCT
admet-686	60	76	aprepitant	aprepitant	ADJ
admet-686	60	77	,	,	PUNCT
admet-686	60	78	carvedilol	carvedilol	NOUN
admet-686	60	79	,	,	PUNCT
admet-686	60	80	zafirlukast	zafirlukast	NOUN
admet-686	60	81	,	,	PUNCT
admet-686	60	82	tadalafil	tadalafil	PROPN
admet-686	60	83	)	)	PUNCT
admet-686	60	84	,	,	PUNCT
admet-686	60	85	and	and	CCONJ
admet-686	60	86	uncharged	uncharged	ADJ
admet-686	60	87	drugs	drug	NOUN
admet-686	60	88	(	(	PUNCT
admet-686	60	89	fenofibrate	fenofibrate	NOUN
admet-686	60	90	,	,	PUNCT
admet-686	60	91	griseofulvin	griseofulvin	NOUN
admet-686	60	92	,	,	PUNCT
admet-686	60	93	felodipine	felodipine	NOUN
admet-686	60	94	,	,	PUNCT
admet-686	60	95	probucol	probucol	PROPN
admet-686	60	96	)	)	PUNCT
admet-686	60	97	were	be	AUX
admet-686	60	98	tested	test	VERB
admet-686	60	99	.	.	PUNCT
admet-686	61	1	with	with	ADP
admet-686	61	2	the	the	DET
admet-686	61	3	exception	exception	NOUN
admet-686	61	4	of	of	ADP
admet-686	61	5	pancreatin	pancreatin	ADJ
admet-686	61	6	,	,	PUNCT
admet-686	61	7	all	all	PRON
admet-686	61	8	of	of	ADP
admet-686	61	9	the	the	DET
admet-686	61	10	factors	factor	NOUN
admet-686	61	11	individually	individually	ADV
admet-686	61	12	had	have	VERB
admet-686	61	13	a	a	DET
admet-686	61	14	significant	significant	ADJ
admet-686	61	15	influence	influence	NOUN
admet-686	61	16	on	on	ADP
admet-686	61	17	equilibrium	equilibrium	NOUN
admet-686	61	18	solubility	solubility	NOUN
admet-686	61	19	.	.	PUNCT
admet-686	62	1	differences	difference	NOUN
admet-686	62	2	between	between	ADP
admet-686	62	3	acids	acid	NOUN
admet-686	62	4	,	,	PUNCT
admet-686	62	5	bases	basis	NOUN
admet-686	62	6	,	,	PUNCT
admet-686	62	7	and	and	CCONJ
admet-686	62	8	neutral	neutral	ADJ
admet-686	62	9	drugs	drug	NOUN
admet-686	62	10	were	be	AUX
admet-686	62	11	evident	evident	ADJ
admet-686	62	12	;	;	PUNCT
admet-686	62	13	however	however	ADV
admet-686	62	14	,	,	PUNCT
admet-686	62	15	the	the	DET
admet-686	62	16	study	study	NOUN
admet-686	62	17	also	also	ADV
admet-686	62	18	pointed	point	VERB
admet-686	62	19	towards	towards	ADP
admet-686	62	20	(	(	PUNCT
admet-686	62	21	as	as	SCONJ
admet-686	62	22	many	many	ADJ
admet-686	62	23	other	other	ADJ
admet-686	62	24	studies	study	NOUN
admet-686	62	25	also	also	ADV
admet-686	62	26	have	have	AUX
admet-686	62	27	done	do	VERB
admet-686	62	28	)	)	PUNCT
admet-686	62	29	that	that	SCONJ
admet-686	62	30	responses	response	NOUN
admet-686	62	31	to	to	ADP
admet-686	62	32	changes	change	NOUN
admet-686	62	33	in	in	ADP
admet-686	62	34	a	a	DET
admet-686	62	35	solvent	solvent	NOUN
admet-686	62	36	,	,	PUNCT
admet-686	62	37	e.g.	e.g.	ADV
admet-686	62	38	,	,	PUNCT
admet-686	62	39	micellar	micellar	ADJ
admet-686	62	40	fraction	fraction	NOUN
admet-686	62	41	and	and	CCONJ
admet-686	62	42	composition	composition	NOUN
admet-686	62	43	,	,	PUNCT
admet-686	62	44	salt	salt	NOUN
admet-686	62	45	and	and	CCONJ
admet-686	62	46	ph	ph	ADJ
admet-686	62	47	,	,	PUNCT
admet-686	62	48	are	be	AUX
admet-686	62	49	often	often	ADV
admet-686	62	50	compound	compound	VERB
admet-686	62	51	specific	specific	ADJ
admet-686	62	52	and	and	CCONJ
admet-686	62	53	there	there	PRON
admet-686	62	54	are	be	VERB
admet-686	62	55	no	no	DET
admet-686	62	56	generalizing	generalize	VERB
admet-686	62	57	rules	rule	NOUN
admet-686	62	58	or	or	CCONJ
admet-686	62	59	one	one	NUM
admet-686	62	60	-	-	PUNCT
admet-686	62	61	size	size	NOUN
admet-686	62	62	-	-	PUNCT
admet-686	62	63	fits	fit	VERB
admet-686	62	64	-	-	PUNCT
admet-686	62	65	all	all	DET
admet-686	62	66	solutions	solution	NOUN
admet-686	62	67	.	.	PUNCT
admet-686	63	1	supersaturation	supersaturation	NOUN
admet-686	63	2	,	,	PUNCT
admet-686	63	3	liquid	liquid	NOUN
admet-686	63	4	-	-	PUNCT
admet-686	63	5	liquid	liquid	NOUN
admet-686	63	6	phase	phase	NOUN
admet-686	63	7	separation	separation	NOUN
admet-686	63	8	,	,	PUNCT
admet-686	63	9	amorphous	amorphous	ADJ
admet-686	63	10	solid	solid	ADJ
admet-686	63	11	,	,	PUNCT
admet-686	63	12	oil	oil	NOUN
admet-686	63	13	-	-	PUNCT
admet-686	63	14	to	to	ADP
admet-686	63	15	-	-	PUNCT
admet-686	63	16	crystal	crystal	NOUN
admet-686	63	17	transformations	transformation	NOUN
admet-686	63	18	buffers	buffer	NOUN
admet-686	63	19	can	can	AUX
admet-686	63	20	affect	affect	VERB
admet-686	63	21	the	the	DET
admet-686	63	22	formation	formation	NOUN
admet-686	63	23	of	of	ADP
admet-686	63	24	drug	drug	NOUN
admet-686	63	25	aggregates	aggregate	NOUN
admet-686	63	26	(	(	PUNCT
admet-686	63	27	i.e.	i.e.	X
admet-686	63	28	,	,	PUNCT
admet-686	63	29	molecular	molecular	ADJ
admet-686	63	30	clusters	cluster	NOUN
admet-686	63	31	)	)	PUNCT
admet-686	63	32	.	.	PUNCT
admet-686	64	1	as	as	ADP
admet-686	64	2	an	an	DET
admet-686	64	3	example	example	NOUN
admet-686	64	4	:	:	PUNCT
admet-686	64	5	citrate	citrate	NOUN
admet-686	64	6	,	,	PUNCT
admet-686	64	7	succinate	succinate	NOUN
admet-686	64	8	,	,	PUNCT
admet-686	64	9	phthalate	phthalate	NOUN
admet-686	64	10	increase	increase	NOUN
admet-686	64	11	surface	surface	NOUN
admet-686	64	12	activity	activity	NOUN
admet-686	64	13	of	of	ADP
admet-686	64	14	phenothiazines	phenothiazine	NOUN
admet-686	64	15	;	;	PUNCT
admet-686	64	16	acetate	acetate	NOUN
admet-686	64	17	decreases	decrease	VERB
admet-686	64	18	it	it	PRON
admet-686	64	19	[	[	X
admet-686	64	20	17	17	NUM
admet-686	64	21	]	]	PUNCT
admet-686	64	22	.	.	PUNCT
admet-686	65	1	certain	certain	ADJ
admet-686	65	2	surface	surface	NOUN
admet-686	65	3	active	active	ADJ
admet-686	65	4	bases	basis	NOUN
admet-686	65	5	produce	produce	VERB
admet-686	65	6	oil	oil	NOUN
admet-686	65	7	when	when	SCONJ
admet-686	65	8	the	the	DET
admet-686	65	9	drug	drug	NOUN
admet-686	65	10	hydrochloride	hydrochloride	NOUN
admet-686	65	11	is	be	AUX
admet-686	65	12	converted	convert	VERB
admet-686	65	13	to	to	ADP
admet-686	65	14	the	the	DET
admet-686	65	15	free	free	ADJ
admet-686	65	16	base	base	NOUN
admet-686	65	17	in	in	ADP
admet-686	65	18	situ	situ	NOUN
admet-686	65	19	at	at	ADP
admet-686	65	20	ph	ph	PROPN
admet-686	65	21	>	>	X
admet-686	65	22	phmax	phmax	NOUN
admet-686	65	23	.	.	PUNCT
admet-686	66	1	for	for	ADP
admet-686	66	2	example	example	NOUN
admet-686	66	3	,	,	PUNCT
admet-686	66	4	a	a	DET
admet-686	66	5	30	30	NUM
admet-686	66	6	μm	μm	NOUN
admet-686	66	7	chlorpromazine	chlorpromazine	NOUN
admet-686	66	8	hydrochloride	hydrochloride	NOUN
admet-686	66	9	solution	solution	NOUN
admet-686	66	10	at	at	ADP
admet-686	66	11	ph	ph	ADJ
admet-686	66	12	9	9	NUM
admet-686	66	13	becomes	become	VERB
admet-686	66	14	supersaturated	supersaturated	ADJ
admet-686	66	15	,	,	PUNCT
admet-686	66	16	which	which	PRON
admet-686	66	17	then	then	ADV
admet-686	66	18	partly	partly	ADV
admet-686	66	19	separates	separate	VERB
admet-686	66	20	as	as	ADP
admet-686	66	21	oil	oil	NOUN
admet-686	66	22	,	,	PUNCT
admet-686	66	23	which	which	PRON
admet-686	66	24	is	be	AUX
admet-686	66	25	more	more	ADV
admet-686	66	26	soluble	soluble	ADJ
admet-686	66	27	than	than	ADP
admet-686	66	28	the	the	DET
admet-686	66	29	crystalline	crystalline	ADJ
admet-686	66	30	free	free	ADJ
admet-686	66	31	base	base	NOUN
admet-686	66	32	.	.	PUNCT
admet-686	67	1	in	in	ADP
admet-686	67	2	contrast	contrast	NOUN
admet-686	67	3	,	,	PUNCT
admet-686	67	4	a	a	DET
admet-686	67	5	2	2	NUM
admet-686	67	6	-	-	SYM
admet-686	67	7	5	5	NUM
admet-686	67	8	μm	μm	NUM
admet-686	67	9	alkaline	alkaline	NOUN
admet-686	67	10	solution	solution	NOUN
admet-686	67	11	(	(	PUNCT
admet-686	67	12	ph	ph	NOUN
admet-686	67	13	9	9	NUM
admet-686	67	14	-	-	SYM
admet-686	67	15	12	12	NUM
admet-686	67	16	)	)	PUNCT
admet-686	67	17	prepared	prepare	VERB
admet-686	67	18	from	from	ADP
admet-686	67	19	chlorpromazine	chlorpromazine	NOUN
admet-686	67	20	free	free	ADJ
admet-686	67	21	base	base	NOUN
admet-686	67	22	showed	show	VERB
admet-686	67	23	no	no	DET
admet-686	67	24	surface	surface	NOUN
admet-686	67	25	activity	activity	NOUN
admet-686	67	26	[	[	X
admet-686	67	27	17	17	NUM
admet-686	67	28	]	]	PUNCT
admet-686	67	29	.	.	PUNCT
admet-686	68	1	figure	figure	NOUN
admet-686	68	2	1	1	NUM
admet-686	68	3	shows	show	NOUN
admet-686	68	4	log	log	VERB
admet-686	68	5	solubility	solubility	NOUN
admet-686	68	6	-	-	PUNCT
admet-686	68	7	ph	ph	ADJ
admet-686	68	8	profiles	profile	NOUN
admet-686	68	9	of	of	ADP
admet-686	68	10	haloperidol	haloperidol	PROPN
admet-686	68	11	free	free	ADJ
admet-686	68	12	base	base	NOUN
admet-686	68	13	at	at	ADP
admet-686	68	14	different	different	ADJ
admet-686	68	15	temperatures	temperature	NOUN
admet-686	68	16	and	and	CCONJ
admet-686	68	17	in	in	ADP
admet-686	68	18	different	different	ADJ
admet-686	68	19	buffer	buffer	NOUN
admet-686	68	20	media	medium	NOUN
admet-686	68	21	reported	report	VERB
admet-686	68	22	by	by	ADP
admet-686	68	23	several	several	ADJ
admet-686	68	24	groups	group	NOUN
admet-686	68	25	[	[	X
admet-686	68	26	18	18	NUM
admet-686	68	27	-	-	SYM
admet-686	68	28	21	21	NUM
admet-686	68	29	]	]	PUNCT
admet-686	68	30	.	.	PUNCT
admet-686	69	1	the	the	DET
admet-686	69	2	dashed	dash	VERB
admet-686	69	3	curves	curve	NOUN
admet-686	69	4	refer	refer	VERB
admet-686	69	5	to	to	ADP
admet-686	69	6	the	the	DET
admet-686	69	7	profiles	profile	NOUN
admet-686	69	8	calculated	calculate	VERB
admet-686	69	9	from	from	ADP
admet-686	69	10	the	the	DET
admet-686	69	11	simple	simple	ADJ
admet-686	69	12	henderson	henderson	PROPN
admet-686	69	13	-	-	PUNCT
admet-686	69	14	hasselbalch	hasselbalch	PROPN
admet-686	69	15	(	(	PUNCT
admet-686	69	16	hh	hh	NOUN
admet-686	69	17	)	)	PUNCT
admet-686	69	18	equation	equation	NOUN
admet-686	69	19	(	(	PUNCT
admet-686	69	20	not	not	PART
admet-686	69	21	corrected	correct	VERB
admet-686	69	22	for	for	ADP
admet-686	69	23	ionic	ionic	ADJ
admet-686	69	24	strength	strength	NOUN
admet-686	69	25	or	or	CCONJ
admet-686	69	26	admet	admet	PROPN
admet-686	69	27	&	&	CCONJ
admet-686	69	28	dmpk	dmpk	PROPN
admet-686	69	29	7(2	7(2	NUM
admet-686	69	30	)	)	PUNCT
admet-686	69	31	(	(	PUNCT
admet-686	69	32	2019	2019	NUM
admet-686	69	33	)	)	PUNCT
admet-686	69	34	88	88	NUM
admet-686	69	35	-	-	SYM
admet-686	69	36	105	105	NUM
admet-686	69	37	perspectives	perspective	NOUN
admet-686	69	38	in	in	ADP
admet-686	69	39	solubility	solubility	NOUN
admet-686	69	40	measurements	measurement	NOUN
admet-686	69	41	and	and	CCONJ
admet-686	69	42	interpretation	interpretation	NOUN
admet-686	69	43	doi	doi	PROPN
admet-686	69	44	:	:	PUNCT
admet-686	69	45	10.5599	10.5599	NUM
admet-686	69	46	/	/	SYM
admet-686	69	47	admet.686	admet.686	PRON
admet-686	69	48	91	91	NUM
admet-686	69	49	dilution	dilution	NOUN
admet-686	69	50	effects	effect	NOUN
admet-686	69	51	)	)	PUNCT
admet-686	69	52	,	,	PUNCT
admet-686	69	53	using	use	VERB
admet-686	69	54	the	the	DET
admet-686	69	55	independently	independently	ADV
admet-686	69	56	-	-	PUNCT
admet-686	69	57	determined	determine	VERB
admet-686	69	58	pka	pka	PROPN
admet-686	69	59	values	value	NOUN
admet-686	69	60	appropriate	appropriate	ADJ
admet-686	69	61	for	for	ADP
admet-686	69	62	the	the	DET
admet-686	69	63	temperature	temperature	NOUN
admet-686	69	64	.	.	PUNCT
admet-686	70	1	the	the	DET
admet-686	70	2	solid	solid	ADJ
admet-686	70	3	curves	curve	NOUN
admet-686	70	4	are	be	AUX
admet-686	70	5	calculated	calculate	VERB
admet-686	70	6	using	use	VERB
admet-686	70	7	the	the	DET
admet-686	70	8	refined	refined	ADJ
admet-686	70	9	constants	constant	NOUN
admet-686	70	10	from	from	ADP
admet-686	70	11	fitting	fit	VERB
admet-686	70	12	the	the	DET
admet-686	70	13	measured	measure	VERB
admet-686	70	14	log	log	NOUN
admet-686	70	15	s	s	NOUN
admet-686	70	16	-	-	PUNCT
admet-686	70	17	ph	ph	ADJ
admet-686	70	18	data	datum	NOUN
admet-686	70	19	(	(	PUNCT
admet-686	70	20	filled	fill	VERB
admet-686	70	21	circles	circle	NOUN
admet-686	70	22	)	)	PUNCT
admet-686	70	23	to	to	ADP
admet-686	70	24	the	the	DET
admet-686	70	25	proposed	propose	VERB
admet-686	70	26	equilibrium	equilibrium	NOUN
admet-686	70	27	model	model	NOUN
admet-686	70	28	,	,	PUNCT
admet-686	70	29	using	use	VERB
admet-686	70	30	the	the	DET
admet-686	70	31	pdisol	pdisol	ADJ
admet-686	70	32	-	-	PUNCT
admet-686	70	33	x	x	NOUN
admet-686	70	34	program	program	NOUN
admet-686	70	35	(	(	PUNCT
admet-686	70	36	in	in	ADP
admet-686	70	37	-	-	PUNCT
admet-686	70	38	adme	adme	NOUN
admet-686	70	39	research	research	NOUN
admet-686	70	40	;	;	PUNCT
admet-686	70	41	www.inadme.com/pdisol_x.html	www.inadme.com/pdisol_x.html	NUM
admet-686	70	42	)	)	PUNCT
admet-686	70	43	.	.	PUNCT
admet-686	71	1	s0	s0	PROPN
admet-686	71	2	refers	refer	VERB
admet-686	71	3	to	to	ADP
admet-686	71	4	the	the	DET
admet-686	71	5	thermodynamic	thermodynamic	ADJ
admet-686	71	6	intrinsic	intrinsic	ADJ
admet-686	71	7	solubility	solubility	NOUN
admet-686	71	8	in	in	ADP
admet-686	71	9	pure	pure	ADJ
admet-686	71	10	water	water	NOUN
admet-686	71	11	of	of	ADP
admet-686	71	12	the	the	DET
admet-686	71	13	uncharged	uncharged	ADJ
admet-686	71	14	form	form	NOUN
admet-686	71	15	of	of	ADP
admet-686	71	16	the	the	DET
admet-686	71	17	dissolved	dissolve	VERB
admet-686	71	18	substance	substance	NOUN
admet-686	71	19	in	in	ADP
admet-686	71	20	equilibrium	equilibrium	NOUN
admet-686	71	21	with	with	ADP
admet-686	71	22	the	the	DET
admet-686	71	23	crystalline	crystalline	NOUN
admet-686	71	24	solid	solid	NOUN
admet-686	71	25	.	.	PUNCT
admet-686	72	1	its	its	PRON
admet-686	72	2	value	value	NOUN
admet-686	72	3	is	be	AUX
admet-686	72	4	indicated	indicate	VERB
admet-686	72	5	by	by	ADP
admet-686	72	6	the	the	DET
admet-686	72	7	lowest	low	ADJ
admet-686	72	8	value	value	NOUN
admet-686	72	9	in	in	ADP
admet-686	72	10	the	the	DET
admet-686	72	11	dashed	dash	VERB
admet-686	72	12	curve	curve	NOUN
admet-686	72	13	,	,	PUNCT
admet-686	72	14	in	in	ADP
admet-686	72	15	the	the	DET
admet-686	72	16	highly	highly	ADV
admet-686	72	17	alkaline	alkaline	ADJ
admet-686	72	18	region	region	NOUN
admet-686	72	19	.	.	PUNCT
admet-686	73	1	the	the	DET
admet-686	73	2	supersaturation	supersaturation	NOUN
admet-686	73	3	in	in	ADP
admet-686	73	4	the	the	DET
admet-686	73	5	phmax	phmax	ADJ
admet-686	73	6	region	region	NOUN
admet-686	73	7	noted	note	VERB
admet-686	73	8	in	in	ADP
admet-686	73	9	the	the	DET
admet-686	73	10	case	case	NOUN
admet-686	73	11	of	of	ADP
admet-686	73	12	chlorpromazine	chlorpromazine	NOUN
admet-686	73	13	hydrochloride	hydrochloride	NOUN
admet-686	73	14	also	also	ADV
admet-686	73	15	occurs	occur	VERB
admet-686	73	16	for	for	ADP
admet-686	73	17	the	the	DET
admet-686	73	18	haloperidol	haloperidol	ADJ
admet-686	73	19	mesylate	mesylate	NOUN
admet-686	73	20	salt	salt	NOUN
admet-686	73	21	(	(	PUNCT
admet-686	73	22	as	as	SCONJ
admet-686	73	23	illustrated	illustrate	VERB
admet-686	73	24	in	in	ADP
admet-686	73	25	figs	fig	NOUN
admet-686	73	26	.	.	PUNCT
admet-686	74	1	3c	3c	NUM
admet-686	74	2	,	,	PUNCT
admet-686	74	3	d	d	NOUN
admet-686	74	4	in	in	ADP
admet-686	74	5	ref	ref	NOUN
admet-686	74	6	.	.	PUNCT
admet-686	75	1	[	[	X
admet-686	75	2	4	4	NUM
admet-686	75	3	]	]	NUM
admet-686	75	4	)	)	PUNCT
admet-686	75	5	.	.	PUNCT
admet-686	76	1	however	however	ADV
admet-686	76	2	,	,	PUNCT
admet-686	76	3	it	it	PRON
admet-686	76	4	does	do	AUX
admet-686	76	5	not	not	PART
admet-686	76	6	occur	occur	VERB
admet-686	76	7	for	for	ADP
admet-686	76	8	the	the	DET
admet-686	76	9	haloperidol	haloperidol	PROPN
admet-686	76	10	free	free	ADJ
admet-686	76	11	base	base	NOUN
admet-686	76	12	.	.	PUNCT
admet-686	77	1	figures	figure	NOUN
admet-686	77	2	1a	1a	NUM
admet-686	77	3	,	,	PUNCT
admet-686	77	4	d	d	NOUN
admet-686	77	5	do	do	AUX
admet-686	77	6	show	show	VERB
admet-686	77	7	deviations	deviation	NOUN
admet-686	77	8	from	from	ADP
admet-686	77	9	the	the	DET
admet-686	77	10	theoretical	theoretical	ADJ
admet-686	77	11	dashed	dash	VERB
admet-686	77	12	curve	curve	NOUN
admet-686	77	13	(	(	PUNCT
admet-686	77	14	hh	hh	PROPN
admet-686	77	15	)	)	PUNCT
admet-686	77	16	in	in	ADP
admet-686	77	17	the	the	DET
admet-686	77	18	alkaline	alkaline	NOUN
admet-686	77	19	region	region	NOUN
admet-686	77	20	(	(	PUNCT
admet-686	77	21	ph	ph	PROPN
admet-686	77	22	>	>	X
admet-686	77	23	7	7	NUM
admet-686	77	24	)	)	PUNCT
admet-686	77	25	,	,	PUNCT
admet-686	77	26	where	where	SCONJ
admet-686	77	27	the	the	DET
admet-686	77	28	uncharged	uncharged	ADJ
admet-686	77	29	species	specie	NOUN
admet-686	77	30	appears	appear	VERB
admet-686	77	31	to	to	PART
admet-686	77	32	possess	possess	VERB
admet-686	77	33	elevated	elevated	ADJ
admet-686	77	34	solubility	solubility	NOUN
admet-686	77	35	.	.	PUNCT
admet-686	78	1	figure	figure	NOUN
admet-686	78	2	1	1	NUM
admet-686	78	3	.	.	PUNCT
admet-686	79	1	haloperidol	haloperidol	PROPN
admet-686	79	2	(	(	PUNCT
admet-686	79	3	free	free	ADJ
admet-686	79	4	base	base	NOUN
admet-686	79	5	)	)	PUNCT
admet-686	79	6	log	log	VERB
admet-686	79	7	s	s	NOUN
admet-686	79	8	-	-	PUNCT
admet-686	79	9	ph	ph	ADJ
admet-686	79	10	profiles	profile	NOUN
admet-686	79	11	,	,	PUNCT
admet-686	79	12	illustrating	illustrate	VERB
admet-686	79	13	alkaline	alkaline	NOUN
admet-686	79	14	-	-	PUNCT
admet-686	79	15	region	region	NOUN
admet-686	79	16	distortions	distortion	NOUN
admet-686	79	17	from	from	ADP
admet-686	79	18	the	the	DET
admet-686	79	19	shape	shape	NOUN
admet-686	79	20	expected	expect	VERB
admet-686	79	21	from	from	ADP
admet-686	79	22	the	the	DET
admet-686	79	23	henderson	henderson	PROPN
admet-686	79	24	-	-	PUNCT
admet-686	79	25	hasselbalch	hasselbalch	PROPN
admet-686	79	26	equation	equation	NOUN
admet-686	79	27	(	(	PUNCT
admet-686	79	28	dashed	dash	VERB
admet-686	79	29	blue	blue	ADJ
admet-686	79	30	line	line	NOUN
admet-686	79	31	)	)	PUNCT
admet-686	79	32	.	.	PUNCT
admet-686	80	1	the	the	DET
admet-686	80	2	solid	solid	ADJ
admet-686	80	3	red	red	ADJ
admet-686	80	4	lines	line	NOUN
admet-686	80	5	are	be	AUX
admet-686	80	6	the	the	DET
admet-686	80	7	best	good	ADJ
admet-686	80	8	fit	fit	ADJ
admet-686	80	9	to	to	ADP
admet-686	80	10	the	the	DET
admet-686	80	11	measured	measured	ADJ
admet-686	80	12	data	datum	NOUN
admet-686	80	13	,	,	PUNCT
admet-686	80	14	using	use	VERB
admet-686	80	15	the	the	DET
admet-686	80	16	regression	regression	NOUN
admet-686	80	17	analysis	analysis	NOUN
admet-686	80	18	program	program	NOUN
admet-686	80	19	pdisol	pdisol	ADV
admet-686	80	20	-	-	PUNCT
admet-686	80	21	x	x	PUNCT
admet-686	81	1	[	[	X
admet-686	81	2	22	22	NUM
admet-686	81	3	]	]	PUNCT
admet-686	81	4	.	.	PUNCT
admet-686	82	1	see	see	VERB
admet-686	82	2	text	text	NOUN
admet-686	82	3	for	for	ADP
admet-686	82	4	further	further	ADJ
admet-686	82	5	elaboration	elaboration	NOUN
admet-686	82	6	.	.	PUNCT
admet-686	83	1	several	several	ADJ
admet-686	83	2	phenomena	phenomenon	NOUN
admet-686	83	3	can	can	AUX
admet-686	83	4	account	account	VERB
admet-686	83	5	for	for	ADP
admet-686	83	6	such	such	DET
admet-686	83	7	a	a	DET
admet-686	83	8	behavior	behavior	NOUN
admet-686	83	9	:	:	PUNCT
admet-686	83	10	(	(	PUNCT
admet-686	83	11	i	i	NOUN
admet-686	83	12	)	)	PUNCT
admet-686	83	13	the	the	DET
admet-686	83	14	neutral	neutral	ADJ
admet-686	83	15	(	(	PUNCT
admet-686	83	16	but	but	CCONJ
admet-686	83	17	not	not	PART
admet-686	83	18	the	the	DET
admet-686	83	19	charged	charge	VERB
admet-686	83	20	)	)	PUNCT
admet-686	83	21	species	specie	NOUN
admet-686	83	22	forms	form	VERB
admet-686	83	23	a	a	DET
admet-686	83	24	supersaturated	supersaturated	ADJ
admet-686	83	25	solution	solution	NOUN
admet-686	83	26	;	;	PUNCT
admet-686	83	27	(	(	PUNCT
admet-686	83	28	ii	ii	NOUN
admet-686	83	29	)	)	PUNCT
admet-686	83	30	stable	stable	ADJ
admet-686	83	31	water	water	NOUN
admet-686	83	32	-	-	PUNCT
admet-686	83	33	soluble	soluble	ADJ
admet-686	83	34	uncharged	uncharged	ADJ
admet-686	83	35	aggregates	aggregate	NOUN
admet-686	83	36	of	of	ADP
admet-686	83	37	haloperidol	haloperidol	NOUN
admet-686	83	38	form	form	NOUN
admet-686	83	39	;	;	PUNCT
admet-686	83	40	(	(	PUNCT
admet-686	83	41	iii	iii	X
admet-686	83	42	)	)	PUNCT
admet-686	83	43	the	the	DET
admet-686	83	44	added	add	VERB
admet-686	83	45	crystalline	crystalline	NOUN
admet-686	83	46	free	free	ADJ
admet-686	83	47	base	base	NOUN
admet-686	83	48	,	,	PUNCT
admet-686	83	49	soon	soon	ADV
admet-686	83	50	after	after	ADP
admet-686	83	51	dissolution	dissolution	NOUN
admet-686	83	52	,	,	PUNCT
admet-686	83	53	re	re	NOUN
admet-686	83	54	-	-	VERB
admet-686	83	55	precipitate	precipitate	ADJ
admet-686	83	56	into	into	ADP
admet-686	83	57	an	an	DET
admet-686	83	58	amorphous	amorphous	ADJ
admet-686	83	59	solid	solid	ADJ
admet-686	83	60	phase	phase	NOUN
admet-686	83	61	;	;	PUNCT
admet-686	83	62	(	(	PUNCT
admet-686	83	63	iv	iv	X
admet-686	83	64	)	)	PUNCT
admet-686	83	65	liquidliquid	liquidliquid	ADJ
admet-686	83	66	phase	phase	NOUN
admet-686	83	67	separation	separation	NOUN
admet-686	83	68	(	(	PUNCT
admet-686	83	69	llps	llps	PROPN
admet-686	83	70	)	)	PUNCT
admet-686	83	71	takes	take	VERB
admet-686	83	72	place	place	NOUN
admet-686	83	73	,	,	PUNCT
admet-686	83	74	where	where	SCONJ
admet-686	83	75	oil	oil	NOUN
admet-686	83	76	forms	form	NOUN
admet-686	83	77	as	as	ADP
admet-686	83	78	the	the	DET
admet-686	83	79	second	second	ADJ
admet-686	83	80	liquid	liquid	ADJ
admet-686	83	81	phase	phase	NOUN
admet-686	83	82	,	,	PUNCT
admet-686	83	83	in	in	ADP
admet-686	83	84	addition	addition	NOUN
admet-686	83	85	to	to	ADP
admet-686	83	86	the	the	DET
admet-686	83	87	aqueous	aqueous	ADJ
admet-686	83	88	phase	phase	NOUN
admet-686	83	89	;	;	PUNCT
admet-686	83	90	and	and	CCONJ
admet-686	83	91	(	(	PUNCT
admet-686	83	92	v	v	NOUN
admet-686	83	93	)	)	PUNCT
admet-686	83	94	the	the	DET
admet-686	83	95	free	free	ADJ
admet-686	83	96	-	-	PUNCT
admet-686	83	97	base	base	NOUN
admet-686	83	98	(	(	PUNCT
admet-686	83	99	but	but	CCONJ
admet-686	83	100	not	not	PART
admet-686	83	101	the	the	DET
admet-686	83	102	charged	charge	VERB
admet-686	83	103	-	-	PUNCT
admet-686	83	104	form	form	NOUN
admet-686	83	105	)	)	PUNCT
admet-686	83	106	drug	drug	NOUN
admet-686	83	107	forms	form	VERB
admet-686	83	108	a	a	DET
admet-686	83	109	complex	complex	NOUN
admet-686	83	110	with	with	ADP
admet-686	83	111	a	a	DET
admet-686	83	112	component	component	NOUN
admet-686	83	113	of	of	ADP
admet-686	83	114	the	the	DET
admet-686	83	115	buffer	buffer	NOUN
admet-686	83	116	,	,	PUNCT
admet-686	83	117	thus	thus	ADV
admet-686	83	118	elevating	elevate	VERB
admet-686	83	119	solubility	solubility	NOUN
admet-686	83	120	.	.	PUNCT
admet-686	84	1	overlapping	overlap	VERB
admet-686	84	2	contributions	contribution	NOUN
admet-686	84	3	from	from	ADP
admet-686	84	4	the	the	DET
admet-686	84	5	above	above	ADJ
admet-686	84	6	effects	effect	NOUN
admet-686	84	7	may	may	AUX
admet-686	84	8	also	also	ADV
admet-686	84	9	play	play	VERB
admet-686	84	10	a	a	DET
admet-686	84	11	role	role	NOUN
admet-686	84	12	.	.	PUNCT
admet-686	85	1	without	without	ADP
admet-686	85	2	a	a	DET
admet-686	85	3	specific	specific	ADJ
admet-686	85	4	molecular	molecular	ADJ
admet-686	85	5	model	model	NOUN
admet-686	85	6	for	for	ADP
admet-686	85	7	the	the	DET
admet-686	85	8	phenomenon	phenomenon	NOUN
admet-686	85	9	of	of	ADP
admet-686	85	10	‘	'	PUNCT
admet-686	85	11	supersaturation	supersaturation	NOUN
admet-686	85	12	’	'	PUNCT
admet-686	85	13	(	(	PUNCT
admet-686	85	14	i	i	NOUN
admet-686	85	15	)	)	PUNCT
admet-686	85	16	,	,	PUNCT
admet-686	85	17	it	it	PRON
admet-686	85	18	is	be	AUX
admet-686	85	19	not	not	PART
admet-686	85	20	clear	clear	ADJ
admet-686	85	21	why	why	SCONJ
admet-686	85	22	the	the	DET
admet-686	85	23	extent	extent	NOUN
admet-686	85	24	of	of	ADP
admet-686	85	25	distortions	distortion	NOUN
admet-686	85	26	is	be	AUX
admet-686	85	27	different	different	ADJ
admet-686	85	28	in	in	ADP
admet-686	85	29	each	each	PRON
admet-686	85	30	of	of	ADP
admet-686	85	31	the	the	DET
admet-686	85	32	frames	frame	NOUN
admet-686	85	33	of	of	ADP
admet-686	85	34	figure	figure	NOUN
admet-686	85	35	1	1	NUM
admet-686	85	36	(	(	PUNCT
admet-686	85	37	and	and	CCONJ
admet-686	85	38	also	also	ADV
admet-686	85	39	in	in	ADP
admet-686	85	40	figs	fig	NOUN
admet-686	85	41	.	.	PUNCT
admet-686	86	1	3b	3b	NUM
admet-686	86	2	,	,	PUNCT
admet-686	86	3	c	c	X
admet-686	86	4	,	,	PUNCT
admet-686	86	5	e	e	NOUN
admet-686	86	6	in	in	ADP
admet-686	86	7	ref	ref	NOUN
admet-686	86	8	.	.	PUNCT
admet-686	87	1	[	[	X
admet-686	87	2	4	4	NUM
admet-686	87	3	]	]	NUM
admet-686	87	4	)	)	PUNCT
admet-686	87	5	.	.	PUNCT
admet-686	88	1	case	case	NOUN
admet-686	88	2	http://www.in-adme.com/pdisol_x.html	http://www.in-adme.com/pdisol_x.html	VERB
admet-686	88	3	http://www.in-adme.com/pdisol_x.html	http://www.in-adme.com/pdisol_x.html	ADV
admet-686	88	4	bergström	bergström	NOUN
admet-686	88	5	and	and	CCONJ
admet-686	88	6	avdeef	avdeef	PROPN
admet-686	88	7	admet	admet	PROPN
admet-686	88	8	&	&	CCONJ
admet-686	88	9	dmpk	dmpk	PROPN
admet-686	88	10	7(2	7(2	NUM
admet-686	88	11	)	)	PUNCT
admet-686	88	12	(	(	PUNCT
admet-686	88	13	2019	2019	NUM
admet-686	88	14	)	)	PUNCT
admet-686	88	15	88	88	NUM
admet-686	88	16	-	-	SYM
admet-686	88	17	105	105	NUM
admet-686	88	18	92	92	NUM
admet-686	88	19	(	(	PUNCT
admet-686	88	20	ii	ii	NOUN
admet-686	88	21	)	)	PUNCT
admet-686	88	22	–	–	PUNCT
admet-686	88	23	thermodynamically	thermodynamically	ADV
admet-686	88	24	-	-	PUNCT
admet-686	88	25	stable	stable	ADJ
admet-686	88	26	aggregation	aggregation	NOUN
admet-686	88	27	reaction	reaction	NOUN
admet-686	88	28	–	–	PUNCT
admet-686	88	29	is	be	AUX
admet-686	88	30	not	not	PART
admet-686	88	31	supported	support	VERB
admet-686	88	32	by	by	ADP
admet-686	88	33	the	the	DET
admet-686	88	34	data	datum	NOUN
admet-686	88	35	,	,	PUNCT
admet-686	88	36	since	since	SCONJ
admet-686	88	37	the	the	DET
admet-686	88	38	distortion	distortion	NOUN
admet-686	88	39	is	be	AUX
admet-686	88	40	different	different	ADJ
admet-686	88	41	in	in	ADP
admet-686	88	42	each	each	PRON
admet-686	88	43	of	of	ADP
admet-686	88	44	the	the	DET
admet-686	88	45	frames	frame	NOUN
admet-686	88	46	.	.	PUNCT
admet-686	89	1	cases	case	NOUN
admet-686	89	2	(	(	PUNCT
admet-686	89	3	iii	iii	NOUN
admet-686	89	4	)	)	PUNCT
admet-686	89	5	and	and	CCONJ
admet-686	89	6	(	(	PUNCT
admet-686	89	7	iv	iv	X
admet-686	89	8	)	)	PUNCT
admet-686	89	9	–	–	PUNCT
admet-686	89	10	amorphous	amorphous	ADJ
admet-686	89	11	solid	solid	ADJ
admet-686	89	12	and	and	CCONJ
admet-686	89	13	oil	oil	NOUN
admet-686	89	14	,	,	PUNCT
admet-686	89	15	resp	resp	NOUN
admet-686	89	16	.	.	PUNCT
admet-686	90	1	–	–	PUNCT
admet-686	90	2	are	be	AUX
admet-686	90	3	possible	possible	ADJ
admet-686	90	4	explanations	explanation	NOUN
admet-686	90	5	for	for	ADP
admet-686	90	6	the	the	DET
admet-686	90	7	distortion	distortion	NOUN
admet-686	90	8	.	.	PUNCT
admet-686	91	1	figure	figure	NOUN
admet-686	91	2	1c	1c	NOUN
admet-686	91	3	,	,	PUNCT
admet-686	91	4	based	base	VERB
admet-686	91	5	on	on	ADP
admet-686	91	6	a	a	DET
admet-686	91	7	48	48	NUM
admet-686	91	8	-	-	PUNCT
admet-686	91	9	h	h	NOUN
admet-686	91	10	equilibration	equilibration	NOUN
admet-686	91	11	time	time	NOUN
admet-686	91	12	,	,	PUNCT
admet-686	91	13	shows	show	VERB
admet-686	91	14	no	no	DET
admet-686	91	15	distortion	distortion	NOUN
admet-686	91	16	in	in	ADP
admet-686	91	17	the	the	DET
admet-686	91	18	alkaline	alkaline	NOUN
admet-686	91	19	region	region	NOUN
admet-686	91	20	.	.	PUNCT
admet-686	92	1	it	it	PRON
admet-686	92	2	could	could	AUX
admet-686	92	3	be	be	AUX
admet-686	92	4	that	that	SCONJ
admet-686	92	5	the	the	DET
admet-686	92	6	amorphous	amorphous	ADJ
admet-686	92	7	solid	solid	ADJ
admet-686	92	8	or	or	CCONJ
admet-686	92	9	oil	oil	NOUN
admet-686	92	10	have	have	AUX
admet-686	92	11	essentially	essentially	ADV
admet-686	92	12	converted	convert	VERB
admet-686	92	13	into	into	ADP
admet-686	92	14	the	the	DET
admet-686	92	15	thermodynamically	thermodynamically	ADV
admet-686	92	16	most	most	ADV
admet-686	92	17	stable	stable	ADJ
admet-686	92	18	crystalline	crystalline	NOUN
admet-686	92	19	form	form	NOUN
admet-686	92	20	by	by	ADP
admet-686	92	21	then	then	ADV
admet-686	92	22	,	,	PUNCT
admet-686	92	23	but	but	CCONJ
admet-686	92	24	not	not	PART
admet-686	92	25	entirely	entirely	ADV
admet-686	92	26	during	during	ADP
admet-686	92	27	the	the	DET
admet-686	92	28	24	24	NUM
admet-686	92	29	-	-	PUNCT
admet-686	92	30	h	h	NOUN
admet-686	92	31	equilibration	equilibration	NOUN
admet-686	92	32	in	in	ADP
admet-686	92	33	figures	figure	NOUN
admet-686	92	34	1a	1a	NUM
admet-686	92	35	,	,	PUNCT
admet-686	92	36	d.	d.	PROPN
admet-686	92	37	the	the	DET
admet-686	92	38	extent	extent	NOUN
admet-686	92	39	of	of	ADP
admet-686	92	40	distortion	distortion	NOUN
admet-686	92	41	in	in	ADP
admet-686	92	42	figure	figure	NOUN
admet-686	92	43	1a	1a	NOUN
admet-686	92	44	,	,	PUNCT
admet-686	92	45	compared	compare	VERB
admet-686	92	46	to	to	PART
admet-686	92	47	figure	figure	VERB
admet-686	92	48	1d	1d	NUM
admet-686	92	49	,	,	PUNCT
admet-686	92	50	could	could	AUX
admet-686	92	51	be	be	AUX
admet-686	92	52	indicative	indicative	ADJ
admet-686	92	53	of	of	ADP
admet-686	92	54	a	a	DET
admet-686	92	55	possible	possible	ADJ
admet-686	92	56	role	role	NOUN
admet-686	92	57	for	for	ADP
admet-686	92	58	drug	drug	NOUN
admet-686	92	59	-	-	PUNCT
admet-686	92	60	phosphate	phosphate	NOUN
admet-686	92	61	complex	complex	ADJ
admet-686	92	62	formation	formation	NOUN
admet-686	92	63	(	(	PUNCT
admet-686	92	64	v	v	NOUN
admet-686	92	65	)	)	PUNCT
admet-686	92	66	,	,	PUNCT
admet-686	92	67	since	since	SCONJ
admet-686	92	68	0.15	0.15	NUM
admet-686	92	69	m	m	NOUN
admet-686	92	70	phosphate	phosphate	NOUN
admet-686	92	71	constituted	constitute	VERB
admet-686	92	72	the	the	DET
admet-686	92	73	medium	medium	NOUN
admet-686	92	74	in	in	ADP
admet-686	92	75	figure	figure	NOUN
admet-686	92	76	1a	1a	NOUN
admet-686	92	77	,	,	PUNCT
admet-686	92	78	but	but	CCONJ
admet-686	92	79	no	no	DET
admet-686	92	80	buffers	buffer	NOUN
admet-686	92	81	were	be	AUX
admet-686	92	82	in	in	ADP
admet-686	92	83	added	add	VERB
admet-686	92	84	in	in	ADP
admet-686	92	85	figure	figure	NOUN
admet-686	92	86	1d	1d	NUM
admet-686	92	87	.	.	PUNCT
admet-686	93	1	it	it	PRON
admet-686	93	2	is	be	AUX
admet-686	93	3	evident	evident	ADJ
admet-686	93	4	from	from	ADP
admet-686	93	5	the	the	DET
admet-686	93	6	above	above	ADJ
admet-686	93	7	examples	example	NOUN
admet-686	93	8	that	that	PRON
admet-686	93	9	solid	solid	ADJ
admet-686	93	10	state	state	NOUN
admet-686	93	11	characterization	characterization	NOUN
admet-686	93	12	would	would	AUX
admet-686	93	13	be	be	AUX
admet-686	93	14	needed	need	VERB
admet-686	93	15	to	to	PART
admet-686	93	16	help	help	VERB
admet-686	93	17	decide	decide	VERB
admet-686	93	18	on	on	ADP
admet-686	93	19	the	the	DET
admet-686	93	20	most	most	ADV
admet-686	93	21	likely	likely	ADJ
admet-686	93	22	mechanism	mechanism	NOUN
admet-686	93	23	behind	behind	ADP
admet-686	93	24	the	the	DET
admet-686	93	25	observed	observe	VERB
admet-686	93	26	distortions	distortion	NOUN
admet-686	93	27	in	in	ADP
admet-686	93	28	figure	figure	NOUN
admet-686	93	29	1	1	NUM
admet-686	93	30	.	.	PUNCT
admet-686	93	31	changing	change	VERB
admet-686	93	32	buffer	buffer	NOUN
admet-686	93	33	types	type	NOUN
admet-686	93	34	in	in	ADP
admet-686	93	35	the	the	DET
admet-686	93	36	medium	medium	NOUN
admet-686	93	37	and	and	CCONJ
admet-686	93	38	selecting	select	VERB
admet-686	93	39	different	different	ADJ
admet-686	93	40	equilibration	equilibration	NOUN
admet-686	93	41	-	-	PUNCT
admet-686	93	42	time	time	NOUN
admet-686	93	43	approaches	approach	NOUN
admet-686	93	44	[	[	X
admet-686	93	45	4	4	X
admet-686	93	46	]	]	PUNCT
admet-686	93	47	would	would	AUX
admet-686	93	48	add	add	VERB
admet-686	93	49	further	further	ADJ
admet-686	93	50	insight	insight	NOUN
admet-686	93	51	into	into	ADP
admet-686	93	52	the	the	DET
admet-686	93	53	mechanistic	mechanistic	ADJ
admet-686	93	54	basis	basis	NOUN
admet-686	93	55	for	for	ADP
admet-686	93	56	the	the	DET
admet-686	93	57	shape	shape	NOUN
admet-686	93	58	distortions	distortion	NOUN
admet-686	93	59	in	in	ADP
admet-686	93	60	figure	figure	NOUN
admet-686	93	61	1	1	NUM
admet-686	93	62	.	.	PUNCT
admet-686	94	1	it	it	PRON
admet-686	94	2	is	be	AUX
admet-686	94	3	worth	worth	ADJ
admet-686	94	4	noting	note	VERB
admet-686	94	5	that	that	SCONJ
admet-686	94	6	a	a	DET
admet-686	94	7	comprehensive	comprehensive	ADJ
admet-686	94	8	analysis	analysis	NOUN
admet-686	94	9	of	of	ADP
admet-686	94	10	each	each	PRON
admet-686	94	11	of	of	ADP
admet-686	94	12	the	the	DET
admet-686	94	13	log	log	NOUN
admet-686	94	14	s	s	NOUN
admet-686	94	15	-	-	PUNCT
admet-686	94	16	ph	ph	ADJ
admet-686	94	17	sets	set	NOUN
admet-686	94	18	in	in	ADP
admet-686	94	19	figure	figure	NOUN
admet-686	94	20	1	1	NUM
admet-686	94	21	(	(	PUNCT
admet-686	94	22	e.g.	e.g.	ADV
admet-686	94	23	,	,	PUNCT
admet-686	94	24	mass	mass	ADJ
admet-686	94	25	action	action	NOUN
admet-686	94	26	model	model	NOUN
admet-686	94	27	using	use	VERB
admet-686	94	28	all	all	DET
admet-686	94	29	relevant	relevant	ADJ
admet-686	94	30	chemical	chemical	NOUN
admet-686	94	31	equilibria	equilibrium	NOUN
admet-686	94	32	[	[	X
admet-686	94	33	22	22	NUM
admet-686	94	34	]	]	PUNCT
admet-686	94	35	)	)	PUNCT
admet-686	94	36	yields	yield	NOUN
admet-686	94	37	very	very	ADV
admet-686	94	38	similar	similar	ADJ
admet-686	94	39	log	log	NOUN
admet-686	94	40	s0	s0	NOUN
admet-686	94	41	values	value	NOUN
admet-686	94	42	,	,	PUNCT
admet-686	94	43	showing	show	VERB
admet-686	94	44	systematic	systematic	ADJ
admet-686	94	45	temperature	temperature	NOUN
admet-686	94	46	dependence	dependence	NOUN
admet-686	94	47	.	.	PUNCT
admet-686	95	1	based	base	VERB
admet-686	95	2	on	on	ADP
admet-686	95	3	van’t	van’t	NUM
admet-686	95	4	hoff	hoff	NOUN
admet-686	95	5	analysis	analysis	NOUN
admet-686	95	6	(	(	PUNCT
admet-686	95	7	e.g.	e.g.	ADV
admet-686	95	8	,	,	PUNCT
admet-686	95	9	eq	eq	NOUN
admet-686	95	10	.	.	PUNCT
admet-686	96	1	(	(	PUNCT
admet-686	96	2	3	3	X
admet-686	96	3	)	)	PUNCT
admet-686	96	4	in	in	ADP
admet-686	96	5	ref	ref	NOUN
admet-686	96	6	.	.	PUNCT
admet-686	97	1	[	[	X
admet-686	97	2	23	23	NUM
admet-686	97	3	]	]	NUM
admet-686	97	4	)	)	PUNCT
admet-686	97	5	,	,	PUNCT
admet-686	97	6	the	the	DET
admet-686	97	7	intercept	intercept	NOUN
admet-686	97	8	value	value	NOUN
admet-686	97	9	of	of	ADP
admet-686	97	10	log	log	NOUN
admet-686	97	11	s0	s0	NOUN
admet-686	97	12	25	25	NUM
admet-686	97	13	at	at	ADP
admet-686	97	14	25	25	NUM
admet-686	97	15	°	°	NOUN
admet-686	97	16	c	c	NOUN
admet-686	97	17	is	be	AUX
admet-686	97	18	-5.78	-5.78	PROPN
admet-686	97	19	±0.02	±0.02	PROPN
admet-686	97	20	and	and	CCONJ
admet-686	97	21	the	the	DET
admet-686	97	22	slope	slope	NOUN
admet-686	97	23	value	value	NOUN
admet-686	97	24	(	(	PUNCT
admet-686	97	25	enthalpy	enthalpy	NOUN
admet-686	97	26	of	of	ADP
admet-686	97	27	solution	solution	NOUN
admet-686	97	28	)	)	PUNCT
admet-686	97	29	,	,	PUNCT
admet-686	97	30	δhsol	δhsol	NOUN
admet-686	97	31	o	o	NOUN
admet-686	97	32	=	=	SYM
admet-686	97	33	29	29	NUM
admet-686	97	34	±	±	NUM
admet-686	97	35	6	6	NUM
admet-686	97	36	kj	kj	PROPN
admet-686	97	37	/	/	SYM
admet-686	97	38	mol	mol	PROPN
admet-686	97	39	.	.	PROPN
admet-686	98	1	based	base	VERB
admet-686	98	2	on	on	ADP
admet-686	98	3	the	the	DET
admet-686	98	4	analysis	analysis	NOUN
admet-686	98	5	of	of	ADP
admet-686	98	6	ten	ten	NUM
admet-686	98	7	different	different	ADJ
admet-686	98	8	published	publish	VERB
admet-686	98	9	studies	study	NOUN
admet-686	98	10	,	,	PUNCT
admet-686	98	11	the	the	DET
admet-686	98	12	interlaboratory	interlaboratory	ADJ
admet-686	98	13	mean	mean	NOUN
admet-686	98	14	value	value	NOUN
admet-686	98	15	for	for	ADP
admet-686	98	16	haloperidol	haloperidol	NOUN
admet-686	98	17	is	be	AUX
admet-686	98	18	log	log	NOUN
admet-686	98	19	s0	s0	PROPN
admet-686	98	20	25=	25=	NUM
admet-686	98	21	-5.71	-5.71	NOUN
admet-686	98	22	±	±	NUM
admet-686	98	23	0.17	0.17	NUM
admet-686	98	24	(	(	PUNCT
admet-686	98	25	0.73	0.73	NUM
admet-686	98	26	μg	μg	NOUN
admet-686	98	27	/	/	SYM
admet-686	98	28	ml	ml	NOUN
admet-686	98	29	)	)	PUNCT
admet-686	98	30	for	for	ADP
admet-686	98	31	haloperidol	haloperidol	NOUN
admet-686	98	32	[	[	PUNCT
admet-686	98	33	24	24	NUM
admet-686	98	34	]	]	PUNCT
admet-686	98	35	.	.	PUNCT
admet-686	99	1	the	the	DET
admet-686	99	2	above	above	ADP
admet-686	99	3	0.17	0.17	NUM
admet-686	99	4	log	log	PROPN
admet-686	99	5	unit	unit	NOUN
admet-686	99	6	standard	standard	ADJ
admet-686	99	7	deviation	deviation	NOUN
admet-686	99	8	is	be	AUX
admet-686	99	9	precisely	precisely	ADV
admet-686	99	10	the	the	DET
admet-686	99	11	value	value	NOUN
admet-686	99	12	obtained	obtain	VERB
admet-686	99	13	in	in	ADP
admet-686	99	14	the	the	DET
admet-686	99	15	averaging	averaging	NOUN
admet-686	99	16	of	of	ADP
admet-686	99	17	870	870	NUM
admet-686	99	18	molecules	molecule	NOUN
admet-686	99	19	whose	whose	DET
admet-686	99	20	solubility	solubility	NOUN
admet-686	99	21	was	be	AUX
admet-686	99	22	reported	report	VERB
admet-686	99	23	in	in	ADP
admet-686	99	24	two	two	NUM
admet-686	99	25	or	or	CCONJ
admet-686	99	26	more	more	ADJ
admet-686	99	27	studies	study	NOUN
admet-686	99	28	,	,	PUNCT
admet-686	99	29	as	as	SCONJ
admet-686	99	30	described	describe	VERB
admet-686	99	31	below	below	ADV
admet-686	99	32	.	.	PUNCT
admet-686	100	1	a	a	DET
admet-686	100	2	common	common	ADJ
admet-686	100	3	practice	practice	NOUN
admet-686	100	4	in	in	ADP
admet-686	100	5	the	the	DET
admet-686	100	6	literature	literature	NOUN
admet-686	100	7	is	be	AUX
admet-686	100	8	to	to	PART
admet-686	100	9	report	report	VERB
admet-686	100	10	the	the	DET
admet-686	100	11	measured	measured	ADJ
admet-686	100	12	solubility	solubility	NOUN
admet-686	100	13	near	near	ADP
admet-686	100	14	ph	ph	NOUN
admet-686	100	15	=	=	SYM
admet-686	100	16	pka	pka	PROPN
admet-686	100	17	+	+	PROPN
admet-686	100	18	/2	/2	PROPN
admet-686	100	19	(	(	PUNCT
admet-686	100	20	for	for	ADP
admet-686	100	21	bases	basis	NOUN
admet-686	100	22	/	/	SYM
admet-686	100	23	acids	acid	NOUN
admet-686	100	24	,	,	PUNCT
admet-686	100	25	resp	resp	NOUN
admet-686	100	26	.	.	PUNCT
admet-686	100	27	)	)	PUNCT
admet-686	101	1	as	as	ADP
admet-686	101	2	the	the	DET
admet-686	101	3	intrinsic	intrinsic	ADJ
admet-686	101	4	value	value	NOUN
admet-686	101	5	.	.	PUNCT
admet-686	102	1	the	the	DET
admet-686	102	2	above	above	ADJ
admet-686	102	3	examples	example	NOUN
admet-686	102	4	suggests	suggest	VERB
admet-686	102	5	that	that	SCONJ
admet-686	102	6	caution	caution	NOUN
admet-686	102	7	is	be	AUX
admet-686	102	8	warranted	warrant	VERB
admet-686	102	9	for	for	ADP
admet-686	102	10	such	such	DET
admet-686	102	11	a	a	DET
admet-686	102	12	procedure	procedure	NOUN
admet-686	102	13	:	:	PUNCT
admet-686	102	14	from	from	ADP
admet-686	102	15	figures	figure	NOUN
admet-686	102	16	1a	1a	NUM
admet-686	102	17	,	,	PUNCT
admet-686	102	18	c	c	X
admet-686	102	19	,	,	PUNCT
admet-686	102	20	d	d	PROPN
admet-686	102	21	,	,	PUNCT
admet-686	102	22	the	the	DET
admet-686	102	23	mean	mean	ADJ
admet-686	102	24	value	value	NOUN
admet-686	102	25	would	would	AUX
admet-686	102	26	be	be	AUX
admet-686	102	27	-5.07	-5.07	X
admet-686	102	28	±0.82	±0.82	NOUN
admet-686	102	29	(	(	PUNCT
admet-686	102	30	3.2	3.2	NUM
admet-686	102	31	±16	±16	PROPN
admet-686	102	32	μg	μg	PROPN
admet-686	102	33	/	/	SYM
admet-686	102	34	ml	ml	PROPN
admet-686	102	35	)	)	PUNCT
admet-686	102	36	,	,	PUNCT
admet-686	102	37	which	which	PRON
admet-686	102	38	would	would	AUX
admet-686	102	39	not	not	PART
admet-686	102	40	represent	represent	VERB
admet-686	102	41	the	the	DET
admet-686	102	42	realistic	realistic	ADJ
admet-686	102	43	accuracy	accuracy	NOUN
admet-686	102	44	of	of	ADP
admet-686	102	45	the	the	DET
admet-686	102	46	underlying	underlie	VERB
admet-686	102	47	data	datum	NOUN
admet-686	102	48	.	.	PUNCT
admet-686	103	1	a	a	DET
admet-686	103	2	common	common	ADJ
admet-686	103	3	perception	perception	NOUN
admet-686	103	4	is	be	AUX
admet-686	103	5	that	that	PRON
admet-686	103	6	reproducibility	reproducibility	NOUN
admet-686	103	7	in	in	ADP
admet-686	103	8	solubility	solubility	NOUN
admet-686	103	9	measurements	measurement	NOUN
admet-686	103	10	is	be	AUX
admet-686	103	11	typically	typically	ADV
admet-686	103	12	not	not	PART
admet-686	103	13	better	well	ADJ
admet-686	103	14	than	than	ADP
admet-686	103	15	0.7	0.7	NUM
admet-686	103	16	log	log	NOUN
admet-686	103	17	unit	unit	NOUN
admet-686	103	18	[	[	X
admet-686	103	19	25	25	NUM
admet-686	103	20	]	]	PUNCT
admet-686	103	21	.	.	PUNCT
admet-686	104	1	the	the	DET
admet-686	104	2	haloperidol	haloperidol	PROPN
admet-686	104	3	example	example	NOUN
admet-686	104	4	suggests	suggest	VERB
admet-686	104	5	that	that	SCONJ
admet-686	104	6	better	well	ADJ
admet-686	104	7	reproducibility	reproducibility	NOUN
admet-686	104	8	can	can	AUX
admet-686	104	9	be	be	AUX
admet-686	104	10	achieved	achieve	VERB
admet-686	104	11	if	if	SCONJ
admet-686	104	12	published	publish	VERB
admet-686	104	13	data	datum	NOUN
admet-686	104	14	are	be	AUX
admet-686	104	15	critically	critically	ADV
admet-686	104	16	analyzed	analyze	VERB
admet-686	104	17	.	.	PUNCT
admet-686	105	1	the	the	DET
admet-686	105	2	diclofenac	diclofenac	PROPN
admet-686	105	3	example	example	NOUN
admet-686	105	4	below	below	ADV
admet-686	105	5	will	will	AUX
admet-686	105	6	further	far	ADV
admet-686	105	7	elaborate	elaborate	VERB
admet-686	105	8	this	this	PRON
admet-686	105	9	.	.	PUNCT
admet-686	106	1	figure	figure	NOUN
admet-686	106	2	2	2	NUM
admet-686	106	3	.	.	NOUN
admet-686	106	4	time	time	NOUN
admet-686	106	5	sequence	sequence	NOUN
admet-686	106	6	of	of	ADP
admet-686	106	7	liquid	liquid	NOUN
admet-686	106	8	-	-	PUNCT
admet-686	106	9	liquid	liquid	ADJ
admet-686	106	10	phase	phase	NOUN
admet-686	106	11	boundary	boundary	ADJ
admet-686	106	12	transformation	transformation	NOUN
admet-686	106	13	to	to	ADP
admet-686	106	14	crystalline	crystalline	ADJ
admet-686	106	15	phase	phase	NOUN
admet-686	106	16	at	at	ADP
admet-686	106	17	0	0	NUM
admet-686	106	18	,	,	PUNCT
admet-686	106	19	12	12	NUM
admet-686	106	20	,	,	PUNCT
admet-686	106	21	and	and	CCONJ
admet-686	106	22	22	22	NUM
admet-686	106	23	h	h	NOUN
admet-686	107	1	[	[	X
admet-686	107	2	26	26	NUM
admet-686	107	3	]	]	PUNCT
admet-686	107	4	.	.	PUNCT
admet-686	108	1	reprinted	reprint	VERB
admet-686	108	2	with	with	ADP
admet-686	108	3	permission	permission	NOUN
admet-686	108	4	from	from	ADP
admet-686	108	5	s.	s.	PROPN
admet-686	108	6	veesler	veesler	PROPN
admet-686	108	7	,	,	PUNCT
admet-686	108	8	l.	l.	PROPN
admet-686	108	9	lafferrère	lafferrère	PROPN
admet-686	108	10	,	,	PUNCT
admet-686	108	11	e.	e.	PROPN
admet-686	108	12	garcia	garcia	PROPN
admet-686	108	13	,	,	PUNCT
admet-686	108	14	c.	c.	PROPN
admet-686	108	15	hoff	hoff	PROPN
admet-686	108	16	,	,	PUNCT
admet-686	108	17	phase	phase	NOUN
admet-686	108	18	transitions	transition	NOUN
admet-686	108	19	in	in	ADP
admet-686	108	20	supersaturated	supersaturated	ADJ
admet-686	108	21	drug	drug	NOUN
admet-686	108	22	solution	solution	NOUN
admet-686	108	23	.	.	PUNCT
admet-686	109	1	org	org	NOUN
admet-686	109	2	.	.	PUNCT
admet-686	110	1	proc	proc	PROPN
admet-686	110	2	.	.	PUNCT
admet-686	111	1	res	re	NOUN
admet-686	111	2	.	.	PUNCT
admet-686	112	1	dev	dev	PROPN
admet-686	112	2	.	.	PROPN
admet-686	112	3	7	7	NUM
admet-686	112	4	(	(	PUNCT
admet-686	112	5	2003	2003	NUM
admet-686	112	6	)	)	PUNCT
admet-686	112	7	983	983	NUM
admet-686	112	8	-	-	SYM
admet-686	112	9	989	989	NUM
admet-686	112	10	.	.	PUNCT
admet-686	113	1	copyright	copyright	NOUN
admet-686	113	2	2003	2003	NUM
admet-686	113	3	american	american	PROPN
admet-686	113	4	chemical	chemical	PROPN
admet-686	113	5	society	society	NOUN
admet-686	113	6	.	.	PUNCT
admet-686	114	1	the	the	DET
admet-686	114	2	haloperidol	haloperidol	ADJ
admet-686	114	3	discussion	discussion	NOUN
admet-686	114	4	suggests	suggest	VERB
admet-686	114	5	that	that	SCONJ
admet-686	114	6	oil	oil	NOUN
admet-686	114	7	or	or	CCONJ
admet-686	114	8	amorphous	amorphous	ADJ
admet-686	114	9	solid	solid	ADJ
admet-686	114	10	forms	form	NOUN
admet-686	114	11	in	in	ADP
admet-686	114	12	alkaline	alkaline	NOUN
admet-686	114	13	solutions	solution	NOUN
admet-686	114	14	.	.	PUNCT
admet-686	115	1	generally	generally	ADV
admet-686	115	2	,	,	PUNCT
admet-686	115	3	a	a	DET
admet-686	115	4	supersaturated	supersaturated	ADJ
admet-686	115	5	solution	solution	NOUN
admet-686	115	6	forms	form	NOUN
admet-686	115	7	on	on	ADP
admet-686	115	8	initial	initial	ADJ
admet-686	115	9	dissolution	dissolution	NOUN
admet-686	115	10	.	.	PUNCT
admet-686	116	1	such	such	DET
admet-686	116	2	a	a	DET
admet-686	116	3	solution	solution	NOUN
admet-686	116	4	can	can	AUX
admet-686	116	5	then	then	ADV
admet-686	116	6	spontaneously	spontaneously	ADV
admet-686	116	7	form	form	VERB
admet-686	116	8	two	two	NUM
admet-686	116	9	liquid	liquid	ADJ
admet-686	116	10	phases	phase	NOUN
admet-686	116	11	(	(	PUNCT
admet-686	116	12	aqueous	aqueous	ADJ
admet-686	116	13	and	and	CCONJ
admet-686	116	14	oil	oil	NOUN
admet-686	116	15	)	)	PUNCT
admet-686	116	16	,	,	PUNCT
admet-686	116	17	followed	follow	VERB
admet-686	116	18	soon	soon	ADV
admet-686	116	19	after	after	ADP
admet-686	116	20	by	by	ADP
admet-686	116	21	the	the	DET
admet-686	116	22	appearance	appearance	NOUN
admet-686	116	23	of	of	ADP
admet-686	116	24	crystals	crystal	NOUN
admet-686	116	25	,	,	PUNCT
admet-686	116	26	as	as	SCONJ
admet-686	116	27	shown	show	VERB
admet-686	116	28	in	in	ADP
admet-686	116	29	the	the	DET
admet-686	116	30	time	time	NOUN
admet-686	116	31	sequence	sequence	NOUN
admet-686	116	32	in	in	ADP
admet-686	116	33	figure	figure	NOUN
admet-686	116	34	2	2	NUM
admet-686	116	35	.	.	PUNCT
admet-686	116	36	solute	solute	NOUN
admet-686	116	37	is	be	AUX
admet-686	116	38	transported	transport	VERB
admet-686	116	39	from	from	ADP
admet-686	116	40	oil	oil	NOUN
admet-686	116	41	drops	drop	NOUN
admet-686	116	42	to	to	ADP
admet-686	116	43	crystal	crystal	NOUN
admet-686	116	44	via	via	ADP
admet-686	116	45	the	the	DET
admet-686	116	46	continuous	continuous	ADJ
admet-686	116	47	phase	phase	NOUN
admet-686	116	48	in	in	ADP
admet-686	116	49	a	a	DET
admet-686	116	50	solvent	solvent	NOUN
admet-686	116	51	-	-	PUNCT
admet-686	116	52	mediated	mediate	VERB
admet-686	116	53	process	process	NOUN
admet-686	116	54	in	in	ADP
admet-686	116	55	which	which	PRON
admet-686	116	56	the	the	DET
admet-686	116	57	drops	drop	NOUN
admet-686	116	58	disappear	disappear	VERB
admet-686	116	59	as	as	SCONJ
admet-686	116	60	the	the	DET
admet-686	116	61	crystal	crystal	NOUN
admet-686	116	62	grows	grow	VERB
admet-686	116	63	.	.	PUNCT
admet-686	117	1	after	after	ADP
admet-686	117	2	heating	heat	VERB
admet-686	117	3	and	and	CCONJ
admet-686	117	4	cooling	cool	VERB
admet-686	117	5	the	the	DET
admet-686	117	6	crystals	crystal	NOUN
admet-686	117	7	,	,	PUNCT
admet-686	117	8	llps	llp	NOUN
admet-686	117	9	is	be	AUX
admet-686	117	10	not	not	PART
admet-686	117	11	regenerated	regenerate	VERB
admet-686	117	12	,	,	PUNCT
admet-686	117	13	which	which	PRON
admet-686	117	14	further	far	ADV
admet-686	117	15	confirms	confirm	VERB
admet-686	117	16	that	that	SCONJ
admet-686	117	17	the	the	DET
admet-686	117	18	llps	llp	NOUN
admet-686	117	19	is	be	AUX
admet-686	117	20	not	not	PART
admet-686	117	21	a	a	DET
admet-686	117	22	thermodynamically	thermodynamically	ADV
admet-686	117	23	stable	stable	ADJ
admet-686	117	24	phase	phase	NOUN
admet-686	117	25	[	[	X
admet-686	117	26	26,27	26,27	NUM
admet-686	117	27	]	]	PUNCT
admet-686	117	28	.	.	PUNCT
admet-686	118	1	admet	admet	PROPN
admet-686	118	2	&	&	CCONJ
admet-686	118	3	dmpk	dmpk	PROPN
admet-686	118	4	7(2	7(2	NUM
admet-686	118	5	)	)	PUNCT
admet-686	118	6	(	(	PUNCT
admet-686	118	7	2019	2019	NUM
admet-686	118	8	)	)	PUNCT
admet-686	118	9	88	88	NUM
admet-686	118	10	-	-	SYM
admet-686	118	11	105	105	NUM
admet-686	118	12	perspectives	perspective	NOUN
admet-686	118	13	in	in	ADP
admet-686	118	14	solubility	solubility	NOUN
admet-686	118	15	measurements	measurement	NOUN
admet-686	118	16	and	and	CCONJ
admet-686	118	17	interpretation	interpretation	NOUN
admet-686	118	18	doi	doi	PROPN
admet-686	118	19	:	:	PUNCT
admet-686	118	20	10.5599	10.5599	NUM
admet-686	118	21	/	/	SYM
admet-686	118	22	admet.686	admet.686	PROPN
admet-686	118	23	93	93	NUM
admet-686	118	24	amorphous	amorphous	ADJ
admet-686	118	25	and	and	CCONJ
admet-686	118	26	crystalline	crystalline	ADJ
admet-686	118	27	solids	solid	NOUN
admet-686	118	28	high	high	ADJ
admet-686	118	29	-	-	PUNCT
admet-686	118	30	throughput	throughput	NOUN
admet-686	118	31	solubility	solubility	NOUN
admet-686	118	32	(	(	PUNCT
admet-686	118	33	hts	hts	NOUN
admet-686	118	34	)	)	PUNCT
admet-686	118	35	methods	method	NOUN
admet-686	118	36	,	,	PUNCT
admet-686	118	37	where	where	SCONJ
admet-686	118	38	dmso	dmso	ADJ
admet-686	118	39	solutions	solution	NOUN
admet-686	118	40	of	of	ADP
admet-686	118	41	the	the	DET
admet-686	118	42	sample	sample	NOUN
admet-686	118	43	are	be	AUX
admet-686	118	44	added	add	VERB
admet-686	118	45	to	to	PART
admet-686	118	46	buffer	buffer	VERB
admet-686	118	47	media	medium	NOUN
admet-686	118	48	,	,	PUNCT
admet-686	118	49	generally	generally	ADV
admet-686	118	50	indicate	indicate	VERB
admet-686	118	51	a	a	DET
admet-686	118	52	measure	measure	NOUN
admet-686	118	53	of	of	ADP
admet-686	118	54	the	the	DET
admet-686	118	55	solubility	solubility	NOUN
admet-686	118	56	of	of	ADP
admet-686	118	57	amorphous	amorphous	ADJ
admet-686	118	58	solids	solid	NOUN
admet-686	118	59	,	,	PUNCT
admet-686	118	60	with	with	ADP
admet-686	118	61	values	value	NOUN
admet-686	118	62	greater	great	ADJ
admet-686	118	63	than	than	ADP
admet-686	118	64	that	that	PRON
admet-686	118	65	indicated	indicate	VERB
admet-686	118	66	by	by	ADP
admet-686	118	67	crystalline	crystalline	ADJ
admet-686	118	68	solids	solid	NOUN
admet-686	118	69	.	.	PUNCT
admet-686	119	1	amorphous	amorphous	ADJ
admet-686	119	2	phases	phase	NOUN
admet-686	119	3	are	be	AUX
admet-686	119	4	not	not	PART
admet-686	119	5	thermodynamically	thermodynamically	ADV
admet-686	119	6	stable	stable	ADJ
admet-686	119	7	and	and	CCONJ
admet-686	119	8	will	will	AUX
admet-686	119	9	undergo	undergo	VERB
admet-686	119	10	crystallization	crystallization	NOUN
admet-686	119	11	over	over	ADP
admet-686	119	12	time	time	NOUN
admet-686	119	13	.	.	PUNCT
admet-686	120	1	two	two	NUM
admet-686	120	2	amorphous	amorphous	ADJ
admet-686	120	3	phases	phase	NOUN
admet-686	120	4	may	may	AUX
admet-686	120	5	co	co	VERB
admet-686	120	6	-	-	VERB
admet-686	120	7	exist	exist	VERB
admet-686	120	8	,	,	PUNCT
admet-686	120	9	or	or	CCONJ
admet-686	120	10	a	a	DET
admet-686	120	11	transient	transient	ADJ
admet-686	120	12	oil	oil	NOUN
admet-686	120	13	phase	phase	NOUN
admet-686	120	14	may	may	AUX
admet-686	120	15	appear	appear	VERB
admet-686	120	16	.	.	PUNCT
admet-686	121	1	an	an	DET
admet-686	121	2	example	example	NOUN
admet-686	121	3	of	of	ADP
admet-686	121	4	this	this	PRON
admet-686	121	5	is	be	AUX
admet-686	121	6	shown	show	VERB
admet-686	121	7	in	in	ADP
admet-686	121	8	figure	figure	NOUN
admet-686	121	9	3a	3a	NUM
admet-686	121	10	for	for	ADP
admet-686	121	11	the	the	DET
admet-686	121	12	case	case	NOUN
admet-686	121	13	of	of	ADP
admet-686	121	14	terfenadine	terfenadine	NOUN
admet-686	121	15	measurement	measurement	NOUN
admet-686	121	16	using	use	VERB
admet-686	121	17	the	the	DET
admet-686	121	18	μsol	μsol	NOUN
admet-686	121	19	method	method	NOUN
admet-686	121	20	(	(	PUNCT
admet-686	121	21	pion	pion	PROPN
admet-686	121	22	inc	inc	PROPN
admet-686	121	23	.	.	PROPN
admet-686	121	24	)	)	PUNCT
admet-686	121	25	,	,	PUNCT
admet-686	121	26	with	with	ADP
admet-686	121	27	1	1	NUM
admet-686	121	28	%	%	NOUN
admet-686	121	29	v	v	ADP
admet-686	121	30	/	/	SYM
admet-686	121	31	v	v	NOUN
admet-686	121	32	dmso	dmso	NOUN
admet-686	121	33	in	in	ADP
admet-686	121	34	each	each	PRON
admet-686	121	35	of	of	ADP
admet-686	121	36	the	the	DET
admet-686	121	37	96	96	NUM
admet-686	121	38	-	-	PUNCT
admet-686	121	39	well	well	NOUN
admet-686	121	40	buffer	buffer	NOUN
admet-686	121	41	solutions	solution	NOUN
admet-686	121	42	[	[	X
admet-686	121	43	28	28	NUM
admet-686	121	44	]	]	PUNCT
admet-686	121	45	.	.	PUNCT
admet-686	122	1	the	the	DET
admet-686	122	2	unfilled	unfilled	ADJ
admet-686	122	3	circles	circle	NOUN
admet-686	122	4	represent	represent	VERB
admet-686	122	5	solubility	solubility	NOUN
admet-686	122	6	values	value	NOUN
admet-686	122	7	collected	collect	VERB
admet-686	122	8	at	at	ADP
admet-686	122	9	the	the	DET
admet-686	122	10	end	end	NOUN
admet-686	122	11	of	of	ADP
admet-686	122	12	23	23	NUM
admet-686	122	13	-	-	PUNCT
admet-686	122	14	h	h	NOUN
admet-686	122	15	equilibration	equilibration	NOUN
admet-686	122	16	,	,	PUNCT
admet-686	122	17	and	and	CCONJ
admet-686	122	18	may	may	AUX
admet-686	122	19	suggest	suggest	VERB
admet-686	122	20	the	the	DET
admet-686	122	21	presence	presence	NOUN
admet-686	122	22	of	of	ADP
admet-686	122	23	oil	oil	NOUN
admet-686	122	24	plus	plus	CCONJ
admet-686	122	25	amorphous	amorphous	ADJ
admet-686	122	26	solid	solid	NOUN
admet-686	122	27	.	.	PUNCT
admet-686	123	1	(	(	PUNCT
admet-686	123	2	alternatively	alternatively	ADV
admet-686	123	3	,	,	PUNCT
admet-686	123	4	the	the	DET
admet-686	123	5	‘	'	PUNCT
admet-686	123	6	oil	oil	NOUN
admet-686	123	7	’	'	PUNCT
admet-686	123	8	can	can	AUX
admet-686	123	9	be	be	AUX
admet-686	123	10	a	a	DET
admet-686	123	11	more	more	ADV
admet-686	123	12	energetic	energetic	ADJ
admet-686	123	13	amorphous	amorphous	ADJ
admet-686	123	14	solid	solid	ADJ
admet-686	123	15	co	co	VERB
admet-686	123	16	-	-	VERB
admet-686	123	17	precipitated	precipitate	VERB
admet-686	123	18	with	with	ADP
admet-686	123	19	a	a	DET
admet-686	123	20	more	more	ADV
admet-686	123	21	stable	stable	ADJ
admet-686	123	22	amorphous	amorphous	ADJ
admet-686	123	23	form	form	NOUN
admet-686	123	24	.	.	PUNCT
admet-686	123	25	)	)	PUNCT
admet-686	124	1	the	the	DET
admet-686	124	2	filled	fill	VERB
admet-686	124	3	circles	circle	NOUN
admet-686	124	4	represent	represent	VERB
admet-686	124	5	data	datum	NOUN
admet-686	124	6	collected	collect	VERB
admet-686	124	7	at	at	ADP
admet-686	124	8	68	68	NUM
admet-686	124	9	-	-	PUNCT
admet-686	124	10	h	h	NOUN
admet-686	124	11	equilibration	equilibration	NOUN
admet-686	124	12	time	time	NOUN
admet-686	124	13	,	,	PUNCT
admet-686	124	14	and	and	CCONJ
admet-686	124	15	may	may	AUX
admet-686	124	16	suggest	suggest	VERB
admet-686	124	17	the	the	DET
admet-686	124	18	sole	sole	ADJ
admet-686	124	19	presence	presence	NOUN
admet-686	124	20	of	of	ADP
admet-686	124	21	the	the	DET
admet-686	124	22	more	more	ADV
admet-686	124	23	stable	stable	ADJ
admet-686	124	24	amorphous	amorphous	ADJ
admet-686	124	25	solid	solid	NOUN
admet-686	124	26	.	.	PUNCT
admet-686	125	1	the	the	DET
admet-686	125	2	apparent	apparent	ADJ
admet-686	125	3	solubility	solubility	NOUN
admet-686	125	4	at	at	ADP
admet-686	125	5	ph	ph	PROPN
admet-686	125	6	11	11	NUM
admet-686	125	7	is	be	AUX
admet-686	125	8	1.9	1.9	NUM
admet-686	125	9	μg	μg	NOUN
admet-686	125	10	/	/	SYM
admet-686	125	11	ml	ml	X
admet-686	125	12	for	for	ADP
admet-686	125	13	the	the	DET
admet-686	125	14	shorter	short	ADJ
admet-686	125	15	time	time	NOUN
admet-686	125	16	.	.	PUNCT
admet-686	126	1	this	this	DET
admet-686	126	2	value	value	NOUN
admet-686	126	3	appears	appear	VERB
admet-686	126	4	to	to	PART
admet-686	126	5	be	be	AUX
admet-686	126	6	an	an	DET
admet-686	126	7	order	order	NOUN
admet-686	126	8	of	of	ADP
admet-686	126	9	magnitude	magnitude	NOUN
admet-686	126	10	greater	great	ADJ
admet-686	126	11	than	than	ADP
admet-686	126	12	the	the	DET
admet-686	126	13	analyzed	analyze	VERB
admet-686	126	14	value	value	NOUN
admet-686	126	15	of	of	ADP
admet-686	126	16	0.16	0.16	NUM
admet-686	126	17	μg	μg	NOUN
admet-686	126	18	/	/	SYM
admet-686	126	19	ml	ml	PROPN
admet-686	126	20	,	,	PUNCT
admet-686	126	21	corresponding	correspond	VERB
admet-686	126	22	to	to	ADP
admet-686	126	23	the	the	DET
admet-686	126	24	apparent	apparent	ADJ
admet-686	126	25	intrinsic	intrinsic	ADJ
admet-686	126	26	solubility	solubility	NOUN
admet-686	126	27	of	of	ADP
admet-686	126	28	the	the	DET
admet-686	126	29	more	more	ADV
admet-686	126	30	stable	stable	ADJ
admet-686	126	31	amorphous	amorphous	ADJ
admet-686	126	32	solid	solid	ADJ
admet-686	126	33	.	.	PUNCT
admet-686	127	1	solid	solid	ADJ
admet-686	127	2	state	state	NOUN
admet-686	127	3	characterizations	characterization	NOUN
admet-686	127	4	were	be	AUX
admet-686	127	5	not	not	PART
admet-686	127	6	reported	report	VERB
admet-686	127	7	for	for	ADP
admet-686	127	8	the	the	DET
admet-686	127	9	above	above	ADJ
admet-686	127	10	hts	hts	PROPN
admet-686	127	11	measurements	measurement	NOUN
admet-686	127	12	.	.	PUNCT
admet-686	128	1	figure	figure	VERB
admet-686	128	2	3	3	NUM
admet-686	128	3	.	.	PUNCT
admet-686	128	4	terfenadine	terfenadine	NOUN
admet-686	128	5	examples	example	NOUN
admet-686	128	6	of	of	ADP
admet-686	128	7	oil	oil	NOUN
admet-686	128	8	/	/	SYM
admet-686	128	9	amorphous	amorphous	ADJ
admet-686	128	10	vs.	vs.	X
admet-686	128	11	crystalline	crystalline	NOUN
admet-686	128	12	phases	phase	NOUN
admet-686	128	13	solubility	solubility	NOUN
admet-686	128	14	-	-	PUNCT
admet-686	128	15	ph	ph	ADJ
admet-686	128	16	profiles	profile	NOUN
admet-686	128	17	.	.	PUNCT
admet-686	129	1	(	(	PUNCT
admet-686	129	2	a	a	X
admet-686	129	3	)	)	PUNCT
admet-686	129	4	highthroughput	highthroughput	NOUN
admet-686	129	5	measurement	measurement	NOUN
admet-686	130	1	[	[	X
admet-686	130	2	29	29	NUM
admet-686	130	3	]	]	PUNCT
admet-686	130	4	.	.	PUNCT
admet-686	131	1	dotted	dotted	ADJ
admet-686	131	2	curve	curve	NOUN
admet-686	131	3	is	be	AUX
admet-686	131	4	best	well	ADV
admet-686	131	5	-	-	PUNCT
admet-686	131	6	fit	fit	NOUN
admet-686	131	7	of	of	ADP
admet-686	131	8	23	23	NUM
admet-686	131	9	-	-	PUNCT
admet-686	131	10	h	h	NOUN
admet-686	131	11	equilibration	equilibration	NOUN
admet-686	131	12	data	datum	NOUN
admet-686	131	13	;	;	PUNCT
admet-686	131	14	solid	solid	ADJ
admet-686	131	15	curve	curve	NOUN
admet-686	131	16	is	be	AUX
admet-686	131	17	best	well	ADV
admet-686	131	18	-	-	PUNCT
admet-686	131	19	fit	fit	NOUN
admet-686	131	20	of	of	ADP
admet-686	131	21	68h	68h	ADJ
admet-686	131	22	data	datum	NOUN
admet-686	131	23	.	.	PUNCT
admet-686	132	1	as	as	ADP
admet-686	132	2	a	a	DET
admet-686	132	3	visual	visual	ADJ
admet-686	132	4	guide	guide	NOUN
admet-686	132	5	,	,	PUNCT
admet-686	132	6	the	the	DET
admet-686	132	7	dashed	dash	VERB
admet-686	132	8	curve	curve	NOUN
admet-686	132	9	is	be	AUX
admet-686	132	10	the	the	DET
admet-686	132	11	hh	hh	ADJ
admet-686	132	12	curve	curve	NOUN
admet-686	132	13	calculated	calculate	VERB
admet-686	132	14	for	for	ADP
admet-686	132	15	crystalline	crystalline	NOUN
admet-686	132	16	terfenadine	terfenadine	NOUN
admet-686	132	17	,	,	PUNCT
admet-686	132	18	based	base	VERB
admet-686	132	19	on	on	ADP
admet-686	132	20	the	the	DET
admet-686	132	21	analysis	analysis	NOUN
admet-686	132	22	of	of	ADP
admet-686	132	23	the	the	DET
admet-686	132	24	data	datum	NOUN
admet-686	132	25	from	from	ADP
admet-686	132	26	al	al	PROPN
admet-686	132	27	omari	omari	PROPN
admet-686	132	28	et	et	PROPN
admet-686	132	29	al	al	PROPN
admet-686	132	30	.	.	PROPN
admet-686	133	1	(	(	PUNCT
admet-686	133	2	2007	2007	NUM
admet-686	133	3	)	)	PUNCT
admet-686	134	1	[	[	X
admet-686	134	2	29	29	NUM
admet-686	134	3	]	]	PUNCT
admet-686	134	4	,	,	PUNCT
admet-686	134	5	shown	show	VERB
admet-686	134	6	in	in	ADP
admet-686	134	7	the	the	DET
admet-686	134	8	frame	frame	NOUN
admet-686	134	9	on	on	ADP
admet-686	134	10	the	the	DET
admet-686	134	11	right	right	NOUN
admet-686	134	12	.	.	PUNCT
admet-686	135	1	(	(	PUNCT
admet-686	135	2	b	b	X
admet-686	135	3	)	)	PUNCT
admet-686	135	4	shake	shake	NOUN
admet-686	135	5	-	-	PUNCT
admet-686	135	6	flask	flask	NOUN
admet-686	135	7	thermodynamic	thermodynamic	ADJ
admet-686	135	8	measurements	measurement	NOUN
admet-686	135	9	[	[	X
admet-686	135	10	29	29	NUM
admet-686	135	11	]	]	PUNCT
admet-686	135	12	.	.	PUNCT
admet-686	136	1	see	see	VERB
admet-686	136	2	text	text	NOUN
admet-686	136	3	.	.	PUNCT
admet-686	137	1	the	the	DET
admet-686	137	2	dashed	dash	VERB
admet-686	137	3	curve	curve	NOUN
admet-686	137	4	in	in	ADP
admet-686	137	5	figure	figure	NOUN
admet-686	137	6	3a	3a	PROPN
admet-686	137	7	represents	represent	VERB
admet-686	137	8	the	the	DET
admet-686	137	9	thermodynamic	thermodynamic	ADJ
admet-686	137	10	solubility	solubility	NOUN
admet-686	137	11	of	of	ADP
admet-686	137	12	the	the	DET
admet-686	137	13	crystalline	crystalline	NOUN
admet-686	137	14	solid	solid	ADJ
admet-686	137	15	,	,	PUNCT
admet-686	137	16	0.01	0.01	NUM
admet-686	137	17	μg	μg	PROPN
admet-686	137	18	/	/	SYM
admet-686	137	19	ml	ml	PROPN
admet-686	137	20	,	,	PUNCT
admet-686	137	21	based	base	VERB
admet-686	137	22	on	on	ADP
admet-686	137	23	the	the	DET
admet-686	137	24	reported	report	VERB
admet-686	137	25	citrate	citrate	NOUN
admet-686	137	26	-	-	PUNCT
admet-686	137	27	buffer	buffer	NOUN
admet-686	137	28	data	datum	NOUN
admet-686	137	29	of	of	ADP
admet-686	137	30	al	al	PROPN
admet-686	137	31	omari	omari	PROPN
admet-686	137	32	et	et	PROPN
admet-686	137	33	al	al	PROPN
admet-686	137	34	.	.	PUNCT
admet-686	138	1	[	[	X
admet-686	138	2	29	29	NUM
admet-686	138	3	]	]	PUNCT
admet-686	138	4	.	.	PUNCT
admet-686	139	1	the	the	DET
admet-686	139	2	detailed	detailed	ADJ
admet-686	139	3	analysis	analysis	NOUN
admet-686	139	4	of	of	ADP
admet-686	139	5	the	the	DET
admet-686	139	6	latter	latter	ADJ
admet-686	139	7	is	be	AUX
admet-686	139	8	shown	show	VERB
admet-686	139	9	in	in	ADP
admet-686	139	10	figure	figure	NOUN
admet-686	139	11	3b	3b	NUM
admet-686	139	12	.	.	PUNCT
admet-686	140	1	the	the	DET
admet-686	140	2	authors	author	NOUN
admet-686	140	3	studied	study	VERB
admet-686	140	4	the	the	DET
admet-686	140	5	solubility	solubility	NOUN
admet-686	140	6	characteristics	characteristic	NOUN
admet-686	140	7	in	in	ADP
admet-686	140	8	50	50	NUM
admet-686	140	9	mm	mm	NOUN
admet-686	140	10	phosphate	phosphate	NOUN
admet-686	140	11	(	(	PUNCT
admet-686	140	12	unfilled	unfilled	ADJ
admet-686	140	13	circles	circle	NOUN
admet-686	140	14	)	)	PUNCT
admet-686	140	15	as	as	ADV
admet-686	140	16	well	well	ADV
admet-686	140	17	as	as	ADP
admet-686	140	18	citrate	citrate	NOUN
admet-686	140	19	(	(	PUNCT
admet-686	140	20	filled	fill	VERB
admet-686	140	21	circles	circle	NOUN
admet-686	140	22	)	)	PUNCT
admet-686	140	23	buffer	buffer	NOUN
admet-686	140	24	.	.	PUNCT
admet-686	141	1	the	the	DET
admet-686	141	2	30	30	NUM
admet-686	141	3	°	°	NUM
admet-686	141	4	c	c	NOUN
admet-686	141	5	shake	shake	VERB
admet-686	141	6	-	-	PUNCT
admet-686	141	7	flask	flask	NOUN
admet-686	141	8	data	datum	NOUN
admet-686	141	9	at	at	ADP
admet-686	141	10	48	48	NUM
admet-686	141	11	-	-	PUNCT
admet-686	141	12	h	h	NOUN
admet-686	141	13	equilibration	equilibration	NOUN
admet-686	141	14	appears	appear	VERB
admet-686	141	15	to	to	PART
admet-686	141	16	be	be	AUX
admet-686	141	17	of	of	ADP
admet-686	141	18	good	good	ADJ
admet-686	141	19	quality	quality	NOUN
admet-686	141	20	.	.	PUNCT
admet-686	142	1	the	the	DET
admet-686	142	2	phosphate	phosphate	NOUN
admet-686	142	3	-	-	PUNCT
admet-686	142	4	containing	contain	VERB
admet-686	142	5	medium	medium	NOUN
admet-686	142	6	seems	seem	VERB
admet-686	142	7	to	to	PART
admet-686	142	8	indicate	indicate	VERB
admet-686	142	9	drug	drug	NOUN
admet-686	142	10	-	-	PUNCT
admet-686	142	11	buffer	buffer	NOUN
admet-686	142	12	complexation	complexation	NOUN
admet-686	142	13	for	for	ADP
admet-686	142	14	ph	ph	PROPN
admet-686	142	15	>	>	X
admet-686	142	16	phmax	phmax	X
admet-686	142	17	(	(	PUNCT
admet-686	142	18	not	not	PART
admet-686	142	19	seen	see	VERB
admet-686	142	20	in	in	ADP
admet-686	142	21	the	the	DET
admet-686	142	22	citrate	citrate	NOUN
admet-686	142	23	medium	medium	NOUN
admet-686	142	24	)	)	PUNCT
admet-686	142	25	,	,	PUNCT
admet-686	142	26	as	as	SCONJ
admet-686	142	27	evidenced	evidence	VERB
admet-686	142	28	by	by	ADP
admet-686	142	29	the	the	DET
admet-686	142	30	elevation	elevation	NOUN
admet-686	142	31	in	in	ADP
admet-686	142	32	solubility	solubility	NOUN
admet-686	142	33	above	above	ADP
admet-686	142	34	the	the	DET
admet-686	142	35	dashed	dash	VERB
admet-686	142	36	hh	hh	PROPN
admet-686	142	37	curve	curve	NOUN
admet-686	142	38	(	(	PUNCT
admet-686	142	39	ph	ph	ADJ
admet-686	142	40	7	7	NUM
admet-686	142	41	-	-	SYM
admet-686	142	42	8)	8)	NUM
admet-686	142	43	.	.	PUNCT
admet-686	143	1	the	the	DET
admet-686	143	2	analysis	analysis	NOUN
admet-686	143	3	suggests	suggest	VERB
admet-686	143	4	the	the	DET
admet-686	143	5	equilibrium	equilibrium	NOUN
admet-686	143	6	constant	constant	ADJ
admet-686	143	7	k	k	X
admet-686	144	1	=	=	PUNCT
admet-686	145	1	[	[	X
admet-686	145	2	tf.tfh+.hpo4	tf.tfh+.hpo4	NOUN
admet-686	145	3	2-]/[tf][tfh+][hpo4	2-]/[tf][tfh+][hpo4	NUM
admet-686	146	1	2-	2-	NUM
admet-686	146	2	]	]	X
admet-686	146	3	=	=	SYM
admet-686	146	4	10	10	NUM
admet-686	146	5	+	+	SYM
admet-686	146	6	8.96	8.96	NUM
admet-686	146	7	m-2	m-2	NOUN
admet-686	146	8	for	for	ADP
admet-686	146	9	the	the	DET
admet-686	146	10	monoanionic	monoanionic	ADJ
admet-686	146	11	complex	complex	NOUN
admet-686	146	12	[	[	X
admet-686	146	13	24	24	NUM
admet-686	146	14	]	]	PUNCT
admet-686	146	15	.	.	PUNCT
admet-686	147	1	between	between	ADP
admet-686	147	2	phmax	phmax	PROPN
admet-686	147	3	6.7	6.7	NUM
admet-686	147	4	and	and	CCONJ
admet-686	147	5	ph	ph	ADJ
admet-686	147	6	8.3	8.3	NUM
admet-686	147	7	,	,	PUNCT
admet-686	147	8	the	the	DET
admet-686	147	9	complex	complex	NOUN
admet-686	147	10	appears	appear	VERB
admet-686	147	11	to	to	PART
admet-686	147	12	shed	shed	VERB
admet-686	147	13	one	one	NUM
admet-686	147	14	proton	proton	NOUN
admet-686	147	15	with	with	ADP
admet-686	147	16	increasing	increase	VERB
admet-686	147	17	ph	ph	NOUN
admet-686	147	18	.	.	PROPN
admet-686	147	19	in	in	ADP
admet-686	147	20	both	both	CCONJ
admet-686	147	21	the	the	DET
admet-686	147	22	citrate	citrate	NOUN
admet-686	147	23	and	and	CCONJ
admet-686	147	24	phosphate	phosphate	ADJ
admet-686	147	25	media	medium	NOUN
admet-686	147	26	,	,	PUNCT
admet-686	147	27	at	at	ADP
admet-686	147	28	ph	ph	PROPN
admet-686	147	29	below	below	ADP
admet-686	147	30	phmax	phmax	NOUN
admet-686	147	31	,	,	PUNCT
admet-686	147	32	two	two	NUM
admet-686	147	33	salts	salt	NOUN
admet-686	147	34	form	form	VERB
admet-686	147	35	between	between	ADP
admet-686	147	36	the	the	DET
admet-686	147	37	drug	drug	NOUN
admet-686	147	38	and	and	CCONJ
admet-686	147	39	each	each	DET
admet-686	147	40	buffer	buffer	NOUN
admet-686	147	41	,	,	PUNCT
admet-686	147	42	consistent	consistent	ADJ
admet-686	147	43	with	with	ADP
admet-686	147	44	the	the	DET
admet-686	147	45	solid	solid	ADJ
admet-686	147	46	and	and	CCONJ
admet-686	147	47	dotted	dotted	ADJ
admet-686	147	48	curves	curve	NOUN
admet-686	147	49	being	be	AUX
admet-686	147	50	below	below	ADP
admet-686	147	51	the	the	DET
admet-686	147	52	hh	hh	PROPN
admet-686	147	53	dashed	dash	VERB
admet-686	147	54	curve	curve	NOUN
admet-686	147	55	.	.	PUNCT
admet-686	148	1	the	the	DET
admet-686	148	2	salt	salt	NOUN
admet-686	148	3	solubilities	solubility	NOUN
admet-686	148	4	are	be	AUX
admet-686	148	5	quite	quite	ADV
admet-686	148	6	similar	similar	ADJ
admet-686	148	7	for	for	ADP
admet-686	148	8	the	the	DET
admet-686	148	9	citrate	citrate	NOUN
admet-686	148	10	and	and	CCONJ
admet-686	148	11	phosphate	phosphate	NOUN
admet-686	148	12	systems	system	NOUN
admet-686	148	13	.	.	PUNCT
admet-686	149	1	figure	figure	NOUN
admet-686	149	2	4	4	NUM
admet-686	149	3	shows	show	VERB
admet-686	149	4	a	a	DET
admet-686	149	5	simpler	simple	ADJ
admet-686	149	6	example	example	NOUN
admet-686	149	7	of	of	ADP
admet-686	149	8	a	a	DET
admet-686	149	9	single	single	ADJ
admet-686	149	10	amorphous	amorphous	ADJ
admet-686	149	11	-	-	PUNCT
admet-686	149	12	phase	phase	NOUN
admet-686	149	13	log	log	NOUN
admet-686	149	14	s	s	NOUN
admet-686	149	15	-	-	PUNCT
admet-686	149	16	ph	ph	ADJ
admet-686	149	17	profile	profile	NOUN
admet-686	149	18	of	of	ADP
admet-686	149	19	clotrimazole	clotrimazole	NOUN
admet-686	149	20	,	,	PUNCT
admet-686	149	21	measured	measure	VERB
admet-686	149	22	at	at	ADP
admet-686	149	23	about	about	ADV
admet-686	149	24	1	1	NUM
admet-686	149	25	-	-	PUNCT
admet-686	149	26	h	h	NOUN
admet-686	149	27	equilibration	equilibration	NOUN
admet-686	149	28	time	time	NOUN
admet-686	149	29	,	,	PUNCT
admet-686	149	30	compared	compare	VERB
admet-686	149	31	to	to	ADP
admet-686	149	32	the	the	DET
admet-686	149	33	corresponding	corresponding	ADJ
admet-686	149	34	crystalline	crystalline	NOUN
admet-686	149	35	phase	phase	NOUN
admet-686	149	36	profile	profile	NOUN
admet-686	149	37	,	,	PUNCT
admet-686	149	38	measured	measure	VERB
admet-686	149	39	at	at	ADP
admet-686	149	40	48	48	NUM
admet-686	149	41	-	-	PUNCT
admet-686	149	42	h	h	NOUN
admet-686	149	43	equilibration	equilibration	NOUN
admet-686	149	44	[	[	X
admet-686	149	45	30	30	NUM
admet-686	149	46	]	]	PUNCT
admet-686	149	47	.	.	PUNCT
admet-686	150	1	in	in	ADP
admet-686	150	2	both	both	DET
admet-686	150	3	cases	case	NOUN
admet-686	150	4	,	,	PUNCT
admet-686	150	5	the	the	DET
admet-686	150	6	curves	curve	NOUN
admet-686	150	7	nearly	nearly	ADV
admet-686	150	8	follow	follow	VERB
admet-686	150	9	the	the	DET
admet-686	150	10	ph	ph	ADJ
admet-686	150	11	dependence	dependence	NOUN
admet-686	150	12	calculated	calculate	VERB
admet-686	150	13	by	by	ADP
admet-686	150	14	the	the	DET
admet-686	150	15	henderson	henderson	PROPN
admet-686	150	16	-	-	PUNCT
admet-686	150	17	hasselbalch	hasselbalch	PROPN
admet-686	150	18	equation	equation	NOUN
admet-686	150	19	(	(	PUNCT
admet-686	150	20	with	with	ADP
admet-686	150	21	a	a	DET
admet-686	150	22	constant	constant	ADJ
admet-686	150	23	vertical	vertical	ADJ
admet-686	150	24	displacement	displacement	NOUN
admet-686	150	25	between	between	ADP
admet-686	150	26	the	the	DET
admet-686	150	27	two	two	NUM
admet-686	150	28	)	)	PUNCT
admet-686	150	29	,	,	PUNCT
admet-686	150	30	although	although	SCONJ
admet-686	150	31	bergström	bergström	NOUN
admet-686	150	32	and	and	CCONJ
admet-686	150	33	avdeef	avdeef	PROPN
admet-686	150	34	admet	admet	PROPN
admet-686	150	35	&	&	CCONJ
admet-686	150	36	dmpk	dmpk	PROPN
admet-686	150	37	7(2	7(2	NUM
admet-686	150	38	)	)	PUNCT
admet-686	150	39	(	(	PUNCT
admet-686	150	40	2019	2019	NUM
admet-686	150	41	)	)	PUNCT
admet-686	150	42	88	88	NUM
admet-686	150	43	-	-	SYM
admet-686	150	44	105	105	NUM
admet-686	150	45	94	94	NUM
admet-686	150	46	the	the	DET
admet-686	150	47	amorphous	amorphous	ADJ
admet-686	150	48	curve	curve	NOUN
admet-686	150	49	shows	show	VERB
admet-686	150	50	a	a	DET
admet-686	150	51	slight	slight	ADJ
admet-686	150	52	amount	amount	NOUN
admet-686	150	53	liquid	liquid	NOUN
admet-686	150	54	-	-	PUNCT
admet-686	150	55	liquid	liquid	NOUN
admet-686	150	56	separation	separation	NOUN
admet-686	150	57	above	above	ADP
admet-686	150	58	ph	ph	PROPN
admet-686	150	59	7	7	NUM
admet-686	150	60	,	,	PUNCT
admet-686	150	61	as	as	SCONJ
admet-686	150	62	indicated	indicate	VERB
admet-686	150	63	by	by	ADP
admet-686	150	64	a	a	DET
admet-686	150	65	small	small	ADJ
admet-686	150	66	difference	difference	NOUN
admet-686	150	67	between	between	ADP
admet-686	150	68	the	the	DET
admet-686	150	69	solid	solid	ADJ
admet-686	150	70	and	and	CCONJ
admet-686	150	71	dashed	dash	VERB
admet-686	150	72	upper	upper	ADJ
admet-686	150	73	curves	curve	NOUN
admet-686	150	74	in	in	ADP
admet-686	150	75	neutral	neutral	ADJ
admet-686	150	76	solution	solution	NOUN
admet-686	150	77	(	(	PUNCT
admet-686	150	78	which	which	PRON
admet-686	150	79	is	be	AUX
admet-686	150	80	absent	absent	ADJ
admet-686	150	81	in	in	ADP
admet-686	150	82	the	the	DET
admet-686	150	83	lower	low	ADJ
admet-686	150	84	crystalline	crystalline	NOUN
admet-686	150	85	curves	curve	NOUN
admet-686	150	86	)	)	PUNCT
admet-686	150	87	.	.	PUNCT
admet-686	151	1	figure	figure	VERB
admet-686	151	2	4	4	NUM
admet-686	151	3	.	.	PUNCT
admet-686	151	4	clotrimazole	clotrimazole	NOUN
admet-686	151	5	example	example	NOUN
admet-686	151	6	of	of	ADP
admet-686	151	7	amorphous	amorphous	ADJ
admet-686	151	8	vs.	vs.	X
admet-686	151	9	crystalline	crystalline	NOUN
admet-686	151	10	phase	phase	NOUN
admet-686	151	11	solubility	solubility	NOUN
admet-686	151	12	-	-	PUNCT
admet-686	151	13	ph	ph	ADJ
admet-686	151	14	profiles	profile	NOUN
admet-686	151	15	[	[	X
admet-686	151	16	30	30	NUM
admet-686	151	17	]	]	PUNCT
admet-686	151	18	.	.	PUNCT
admet-686	152	1	see	see	VERB
admet-686	152	2	text	text	NOUN
admet-686	152	3	for	for	ADP
admet-686	152	4	details	detail	NOUN
admet-686	152	5	.	.	PUNCT
admet-686	153	1	pre	pre	ADJ
admet-686	153	2	-	-	ADJ
admet-686	153	3	nucleation	nucleation	ADJ
admet-686	153	4	clusters	cluster	NOUN
admet-686	153	5	(	(	PUNCT
admet-686	153	6	i.e.	i.e.	X
admet-686	153	7	self	self	NOUN
admet-686	153	8	-	-	PUNCT
admet-686	153	9	aggregates	aggregate	NOUN
admet-686	153	10	,	,	PUNCT
admet-686	153	11	sub	sub	NOUN
admet-686	153	12	-	-	NOUN
admet-686	153	13	micelles	micelle	NOUN
admet-686	153	14	,	,	PUNCT
admet-686	153	15	drug	drug	NOUN
admet-686	153	16	-	-	PUNCT
admet-686	153	17	buffer	buffer	NOUN
admet-686	153	18	complexes	complex	NOUN
admet-686	153	19	)	)	PUNCT
admet-686	153	20	although	although	SCONJ
admet-686	153	21	classical	classical	ADJ
admet-686	153	22	nucleation	nucleation	NOUN
admet-686	153	23	theory	theory	NOUN
admet-686	153	24	describes	describe	VERB
admet-686	153	25	drug	drug	NOUN
admet-686	153	26	crystallization	crystallization	NOUN
admet-686	153	27	from	from	ADP
admet-686	153	28	a	a	DET
admet-686	153	29	supersaturated	supersaturated	ADJ
admet-686	153	30	aqueous	aqueous	ADJ
admet-686	153	31	solution	solution	NOUN
admet-686	153	32	,	,	PUNCT
admet-686	153	33	the	the	DET
admet-686	153	34	understanding	understanding	NOUN
admet-686	153	35	of	of	ADP
admet-686	153	36	the	the	DET
admet-686	153	37	molecular	molecular	ADJ
admet-686	153	38	basis	basis	NOUN
admet-686	153	39	underlying	underlie	VERB
admet-686	153	40	the	the	DET
admet-686	153	41	nucleation	nucleation	NOUN
admet-686	153	42	steps	step	NOUN
admet-686	153	43	is	be	AUX
admet-686	153	44	still	still	ADV
admet-686	153	45	incomplete	incomplete	ADJ
admet-686	153	46	[	[	X
admet-686	153	47	31	31	NUM
admet-686	153	48	]	]	PUNCT
admet-686	153	49	.	.	PUNCT
admet-686	154	1	the	the	DET
admet-686	154	2	role	role	NOUN
admet-686	154	3	of	of	ADP
admet-686	154	4	pre	pre	ADJ
admet-686	154	5	-	-	ADJ
admet-686	154	6	nucleation	nucleation	ADJ
admet-686	154	7	clusters	cluster	NOUN
admet-686	154	8	as	as	ADP
admet-686	154	9	solute	solute	NOUN
admet-686	154	10	precursors	precursor	NOUN
admet-686	154	11	to	to	PART
admet-686	154	12	nucleation	nucleation	VERB
admet-686	154	13	and	and	CCONJ
admet-686	154	14	the	the	DET
admet-686	154	15	link	link	NOUN
admet-686	154	16	between	between	ADP
admet-686	154	17	the	the	DET
admet-686	154	18	chemical	chemical	NOUN
admet-686	154	19	speciation	speciation	NOUN
admet-686	154	20	of	of	ADP
admet-686	154	21	homogeneous	homogeneous	ADJ
admet-686	154	22	solutions	solution	NOUN
admet-686	154	23	and	and	CCONJ
admet-686	154	24	the	the	DET
admet-686	154	25	process	process	NOUN
admet-686	154	26	of	of	ADP
admet-686	154	27	phase	phase	NOUN
admet-686	154	28	separation	separation	NOUN
admet-686	154	29	of	of	ADP
admet-686	154	30	such	such	ADJ
admet-686	154	31	clusters	cluster	NOUN
admet-686	154	32	was	be	AUX
admet-686	154	33	reviewed	review	VERB
admet-686	154	34	by	by	ADP
admet-686	154	35	gebauer	gebauer	NOUN
admet-686	154	36	et	et	PROPN
admet-686	154	37	al	al	PROPN
admet-686	154	38	.	.	PUNCT
admet-686	155	1	[	[	X
admet-686	155	2	31	31	NUM
admet-686	155	3	]	]	PUNCT
admet-686	155	4	.	.	PUNCT
admet-686	156	1	sub	sub	ADJ
admet-686	156	2	-	-	ADJ
admet-686	156	3	micellar	micellar	ADJ
admet-686	156	4	pre	pre	ADJ
admet-686	156	5	-	-	ADJ
admet-686	156	6	nucleation	nucleation	ADJ
admet-686	156	7	clusters	cluster	NOUN
admet-686	156	8	form	form	VERB
admet-686	156	9	in	in	ADP
admet-686	156	10	many	many	ADJ
admet-686	156	11	supersaturated	supersaturated	ADJ
admet-686	156	12	solutions	solution	NOUN
admet-686	156	13	:	:	PUNCT
admet-686	156	14	calcium	calcium	NOUN
admet-686	156	15	phosphate	phosphate	NOUN
admet-686	156	16	,	,	PUNCT
admet-686	156	17	amino	amino	ADJ
admet-686	156	18	acids	acid	NOUN
admet-686	156	19	–	–	PUNCT
admet-686	156	20	particularly	particularly	ADV
admet-686	156	21	glycine	glycine	NOUN
admet-686	156	22	(	(	PUNCT
admet-686	156	23	see	see	VERB
admet-686	156	24	below	below	ADV
admet-686	156	25	)	)	PUNCT
admet-686	156	26	,	,	PUNCT
admet-686	156	27	and	and	CCONJ
admet-686	156	28	many	many	ADJ
admet-686	156	29	surface	surface	NOUN
admet-686	156	30	-	-	PUNCT
admet-686	156	31	active	active	ADJ
admet-686	156	32	drug	drug	NOUN
admet-686	156	33	molecules	molecule	NOUN
admet-686	156	34	,	,	PUNCT
admet-686	156	35	such	such	ADJ
admet-686	156	36	as	as	ADP
admet-686	156	37	in	in	ADP
admet-686	156	38	phosphate	phosphate	NOUN
admet-686	156	39	-	-	PUNCT
admet-686	156	40	buffered	buffer	VERB
admet-686	156	41	solutions	solution	NOUN
admet-686	156	42	of	of	ADP
admet-686	156	43	chlorpromazine	chlorpromazine	NOUN
admet-686	156	44	,	,	PUNCT
admet-686	156	45	acetylpromazine	acetylpromazine	NOUN
admet-686	156	46	,	,	PUNCT
admet-686	156	47	verapamil	verapamil	NOUN
admet-686	156	48	,	,	PUNCT
admet-686	156	49	orphenadrine	orphenadrine	PROPN
admet-686	156	50	,	,	PUNCT
admet-686	156	51	hydralazine	hydralazine	PROPN
admet-686	156	52	,	,	PUNCT
admet-686	156	53	pramoxine	pramoxine	NOUN
admet-686	156	54	,	,	PUNCT
admet-686	156	55	and	and	CCONJ
admet-686	156	56	amiodarone	amiodarone	NOUN
admet-686	156	57	,	,	PUNCT
admet-686	156	58	at	at	ADP
admet-686	156	59	ph	ph	NOUN
admet-686	156	60	slightly	slightly	ADV
admet-686	156	61	above	above	ADP
admet-686	156	62	that	that	PRON
admet-686	156	63	of	of	ADP
admet-686	156	64	phmax	phmax	PROPN
admet-686	156	65	[	[	X
admet-686	156	66	21,32	21,32	NUM
admet-686	156	67	]	]	PUNCT
admet-686	156	68	.	.	PUNCT
admet-686	157	1	the	the	DET
admet-686	157	2	buffers	buffer	NOUN
admet-686	157	3	in	in	ADP
admet-686	157	4	solution	solution	NOUN
admet-686	157	5	critically	critically	ADV
admet-686	157	6	influence	influence	VERB
admet-686	157	7	the	the	DET
admet-686	157	8	stability	stability	NOUN
admet-686	157	9	of	of	ADP
admet-686	157	10	such	such	ADJ
admet-686	157	11	clusters	cluster	NOUN
admet-686	157	12	.	.	PUNCT
admet-686	158	1	the	the	DET
admet-686	158	2	link	link	NOUN
admet-686	158	3	between	between	ADP
admet-686	158	4	the	the	DET
admet-686	158	5	clusters	cluster	NOUN
admet-686	158	6	and	and	CCONJ
admet-686	158	7	the	the	DET
admet-686	158	8	kinetics	kinetic	NOUN
admet-686	158	9	of	of	ADP
admet-686	158	10	crystallization	crystallization	NOUN
admet-686	158	11	is	be	AUX
admet-686	158	12	still	still	ADV
admet-686	158	13	work	work	NOUN
admet-686	158	14	in	in	ADP
admet-686	158	15	progress	progress	NOUN
admet-686	158	16	,	,	PUNCT
admet-686	158	17	and	and	CCONJ
admet-686	158	18	could	could	AUX
admet-686	158	19	turn	turn	VERB
admet-686	158	20	out	out	ADP
admet-686	158	21	to	to	PART
admet-686	158	22	be	be	AUX
admet-686	158	23	a	a	DET
admet-686	158	24	vibrant	vibrant	ADJ
admet-686	158	25	area	area	NOUN
admet-686	158	26	for	for	ADP
admet-686	158	27	future	future	ADJ
admet-686	158	28	investigations	investigation	NOUN
admet-686	158	29	.	.	PUNCT
admet-686	159	1	it	it	PRON
admet-686	159	2	should	should	AUX
admet-686	159	3	also	also	ADV
admet-686	159	4	be	be	AUX
admet-686	159	5	noted	note	VERB
admet-686	159	6	that	that	SCONJ
admet-686	159	7	the	the	DET
admet-686	159	8	loss	loss	NOUN
admet-686	159	9	of	of	ADP
admet-686	159	10	supersaturation	supersaturation	NOUN
admet-686	159	11	may	may	AUX
admet-686	159	12	potentially	potentially	ADV
admet-686	159	13	start	start	VERB
admet-686	159	14	at	at	ADP
admet-686	159	15	the	the	DET
admet-686	159	16	surface	surface	NOUN
admet-686	159	17	of	of	ADP
admet-686	159	18	the	the	DET
admet-686	159	19	dissolving	dissolve	VERB
admet-686	159	20	material	material	NOUN
admet-686	159	21	that	that	PRON
admet-686	159	22	is	be	AUX
admet-686	159	23	provided	provide	VERB
admet-686	159	24	in	in	ADP
admet-686	159	25	excess	excess	ADJ
admet-686	159	26	and	and	CCONJ
admet-686	159	27	not	not	PART
admet-686	159	28	always	always	ADV
admet-686	159	29	from	from	ADP
admet-686	159	30	the	the	DET
admet-686	159	31	supersaturated	supersaturated	ADJ
admet-686	159	32	solution	solution	NOUN
admet-686	159	33	[	[	X
admet-686	159	34	33	33	NUM
admet-686	159	35	]	]	PUNCT
admet-686	159	36	.	.	PUNCT
admet-686	160	1	solubility	solubility	NOUN
admet-686	160	2	-	-	PUNCT
admet-686	160	3	ph	ph	NOUN
admet-686	160	4	profiles	profile	NOUN
admet-686	160	5	can	can	AUX
admet-686	160	6	indicate	indicate	VERB
admet-686	160	7	self	self	NOUN
admet-686	160	8	-	-	PUNCT
admet-686	160	9	aggregation	aggregation	NOUN
admet-686	160	10	/	/	SYM
admet-686	160	11	cluster	cluster	NOUN
admet-686	160	12	formations	formation	NOUN
admet-686	160	13	.	.	PUNCT
admet-686	161	1	in	in	ADP
admet-686	161	2	the	the	DET
admet-686	161	3	ph	ph	ADJ
admet-686	161	4	region	region	NOUN
admet-686	161	5	where	where	SCONJ
admet-686	161	6	the	the	DET
admet-686	161	7	drug	drug	NOUN
admet-686	161	8	is	be	AUX
admet-686	161	9	charged	charge	VERB
admet-686	161	10	and	and	CCONJ
admet-686	161	11	self	self	NOUN
admet-686	161	12	-	-	PUNCT
admet-686	161	13	aggregation	aggregation	NOUN
admet-686	161	14	takes	take	VERB
admet-686	161	15	place	place	NOUN
admet-686	161	16	,	,	PUNCT
admet-686	161	17	the	the	DET
admet-686	161	18	slope	slope	NOUN
admet-686	161	19	in	in	ADP
admet-686	161	20	the	the	DET
admet-686	161	21	log	log	NOUN
admet-686	161	22	s	s	NOUN
admet-686	161	23	-	-	PUNCT
admet-686	161	24	ph	ph	ADJ
admet-686	161	25	plot	plot	NOUN
admet-686	161	26	can	can	AUX
admet-686	161	27	reveal	reveal	VERB
admet-686	161	28	the	the	DET
admet-686	161	29	order	order	NOUN
admet-686	161	30	of	of	ADP
admet-686	161	31	aggregation	aggregation	NOUN
admet-686	161	32	[	[	X
admet-686	161	33	28	28	NUM
admet-686	161	34	]	]	PUNCT
admet-686	161	35	.	.	PUNCT
admet-686	162	1	figure	figure	NOUN
admet-686	162	2	5	5	NUM
admet-686	162	3	shows	show	VERB
admet-686	162	4	three	three	NUM
admet-686	162	5	examples	example	NOUN
admet-686	162	6	indicating	indicate	VERB
admet-686	162	7	formation	formation	NOUN
admet-686	162	8	of	of	ADP
admet-686	162	9	charged	charge	VERB
admet-686	162	10	aggregates	aggregate	NOUN
admet-686	162	11	.	.	PUNCT
admet-686	163	1	in	in	ADP
admet-686	163	2	figure	figure	NOUN
admet-686	163	3	5a	5a	NUM
admet-686	163	4	,	,	PUNCT
admet-686	163	5	brequinar	brequinar	NOUN
admet-686	163	6	appears	appear	VERB
admet-686	163	7	to	to	PART
admet-686	163	8	form	form	VERB
admet-686	163	9	a	a	DET
admet-686	163	10	negatively	negatively	ADV
admet-686	163	11	-	-	PUNCT
admet-686	163	12	charged	charge	VERB
admet-686	163	13	dimer	dimer	NOUN
admet-686	163	14	at	at	ADP
admet-686	163	15	ph	ph	NOUN
admet-686	163	16	above	above	ADP
admet-686	163	17	7	7	NUM
admet-686	163	18	,	,	PUNCT
admet-686	163	19	as	as	SCONJ
admet-686	163	20	indicated	indicate	VERB
admet-686	163	21	by	by	ADP
admet-686	163	22	a	a	DET
admet-686	163	23	slope	slope	NOUN
admet-686	163	24	of	of	ADP
admet-686	163	25	+2	+2	PROPN
admet-686	163	26	in	in	ADP
admet-686	163	27	the	the	DET
admet-686	163	28	log	log	NOUN
admet-686	163	29	s	s	NOUN
admet-686	163	30	-	-	PUNCT
admet-686	163	31	ph	ph	ADJ
admet-686	163	32	plot	plot	NOUN
admet-686	163	33	;	;	PUNCT
admet-686	163	34	the	the	DET
admet-686	163	35	corresponding	correspond	VERB
admet-686	163	36	sodium	sodium	NOUN
admet-686	163	37	-	-	PUNCT
admet-686	163	38	drug	drug	NOUN
admet-686	163	39	salt	salt	NOUN
admet-686	163	40	precipitates	precipitate	NOUN
admet-686	163	41	above	above	ADP
admet-686	163	42	ph	ph	NOUN
admet-686	163	43	9	9	NUM
admet-686	163	44	[	[	SYM
admet-686	163	45	34	34	NUM
admet-686	163	46	]	]	PUNCT
admet-686	163	47	.	.	PUNCT
admet-686	164	1	figure	figure	NOUN
admet-686	164	2	5b	5b	PROPN
admet-686	164	3	shows	show	VERB
admet-686	164	4	the	the	DET
admet-686	164	5	surface	surface	NOUN
admet-686	164	6	active	active	ADJ
admet-686	164	7	molecule	molecule	NOUN
admet-686	164	8	,	,	PUNCT
admet-686	164	9	3-(4	3-(4	NUM
admet-686	164	10	-	-	PUNCT
admet-686	164	11	heptylbenzoyl)-benzoic	heptylbenzoyl)-benzoic	NOUN
admet-686	164	12	acid	acid	NOUN
admet-686	164	13	,	,	PUNCT
admet-686	164	14	apparently	apparently	ADV
admet-686	164	15	forming	form	VERB
admet-686	164	16	a	a	DET
admet-686	164	17	negatively	negatively	ADV
admet-686	164	18	-	-	PUNCT
admet-686	164	19	charged	charge	VERB
admet-686	164	20	octamer	octamer	NOUN
admet-686	164	21	above	above	ADP
admet-686	164	22	ph	ph	ADJ
admet-686	164	23	7	7	NUM
admet-686	164	24	,	,	PUNCT
admet-686	164	25	as	as	SCONJ
admet-686	164	26	indicated	indicate	VERB
admet-686	164	27	by	by	ADP
admet-686	164	28	the	the	DET
admet-686	164	29	slope	slope	NOUN
admet-686	164	30	of	of	ADP
admet-686	164	31	+8	+8	PROPN
admet-686	164	32	in	in	ADP
admet-686	164	33	the	the	DET
admet-686	164	34	plot	plot	NOUN
admet-686	164	35	[	[	X
admet-686	164	36	35	35	NUM
admet-686	164	37	]	]	PUNCT
admet-686	164	38	.	.	PUNCT
admet-686	165	1	the	the	DET
admet-686	165	2	authors	author	NOUN
admet-686	165	3	proposed	propose	VERB
admet-686	165	4	that	that	SCONJ
admet-686	165	5	anionic	anionic	ADJ
admet-686	165	6	micelles	micelle	NOUN
admet-686	165	7	formed	form	VERB
admet-686	165	8	,	,	PUNCT
admet-686	165	9	with	with	ADP
admet-686	165	10	a	a	DET
admet-686	165	11	critical	critical	ADJ
admet-686	165	12	micelle	micelle	NOUN
admet-686	165	13	concentration	concentration	NOUN
admet-686	165	14	of	of	ADP
admet-686	165	15	about	about	ADV
admet-686	165	16	0.3	0.3	NUM
admet-686	165	17	mm	mm	NOUN
admet-686	165	18	.	.	PUNCT
admet-686	166	1	figure	figure	NOUN
admet-686	166	2	5c	5c	PROPN
admet-686	166	3	shows	show	VERB
admet-686	166	4	ciprofloxacin	ciprofloxacin	NOUN
admet-686	166	5	cation	cation	NOUN
admet-686	166	6	appearing	appear	VERB
admet-686	166	7	to	to	PART
admet-686	166	8	form	form	VERB
admet-686	166	9	a	a	DET
admet-686	166	10	pentameric	pentameric	NOUN
admet-686	166	11	aggregate	aggregate	NOUN
admet-686	166	12	below	below	ADP
admet-686	166	13	ph	ph	PROPN
admet-686	166	14	5	5	NUM
admet-686	166	15	(	(	PUNCT
admet-686	166	16	slope	slope	NOUN
admet-686	166	17	=	=	SYM
admet-686	166	18	-5	-5	NOUN
admet-686	166	19	)	)	PUNCT
admet-686	166	20	,	,	PUNCT
admet-686	166	21	overlapping	overlap	VERB
admet-686	166	22	with	with	ADP
admet-686	166	23	the	the	DET
admet-686	166	24	formation	formation	NOUN
admet-686	166	25	of	of	ADP
admet-686	166	26	a	a	DET
admet-686	166	27	phosphate	phosphate	ADJ
admet-686	166	28	salt	salt	NOUN
admet-686	166	29	at	at	ADP
admet-686	166	30	lower	low	ADJ
admet-686	166	31	ph	ph	NOUN
admet-686	166	32	[	[	X
admet-686	166	33	36	36	NUM
admet-686	166	34	]	]	PUNCT
admet-686	166	35	.	.	PUNCT
admet-686	167	1	(	(	PUNCT
admet-686	167	2	the	the	DET
admet-686	167	3	possibility	possibility	NOUN
admet-686	167	4	of	of	ADP
admet-686	167	5	the	the	DET
admet-686	167	6	formation	formation	NOUN
admet-686	167	7	of	of	ADP
admet-686	167	8	a	a	DET
admet-686	167	9	soluble	soluble	ADJ
admet-686	167	10	drug	drug	NOUN
admet-686	167	11	-	-	PUNCT
admet-686	167	12	phosphate	phosphate	NOUN
admet-686	167	13	complex	complex	NOUN
admet-686	167	14	near	near	ADP
admet-686	167	15	ph	ph	ADJ
admet-686	167	16	5	5	NUM
admet-686	167	17	has	have	AUX
admet-686	167	18	not	not	PART
admet-686	167	19	been	be	AUX
admet-686	167	20	explored	explore	VERB
admet-686	167	21	.	.	PUNCT
admet-686	167	22	)	)	PUNCT
admet-686	168	1	most	most	ADV
admet-686	168	2	often	often	ADV
admet-686	168	3	,	,	PUNCT
admet-686	168	4	when	when	SCONJ
admet-686	168	5	such	such	ADJ
admet-686	168	6	sub	sub	ADJ
admet-686	168	7	-	-	ADJ
admet-686	168	8	micellar	micellar	ADJ
admet-686	168	9	charged	charge	VERB
admet-686	168	10	aggregates	aggregate	NOUN
admet-686	168	11	form	form	NOUN
admet-686	168	12	,	,	PUNCT
admet-686	168	13	the	the	DET
admet-686	168	14	distortion	distortion	NOUN
admet-686	168	15	in	in	ADP
admet-686	168	16	the	the	DET
admet-686	168	17	log	log	NOUN
admet-686	168	18	s	s	NOUN
admet-686	168	19	-	-	PUNCT
admet-686	168	20	ph	ph	ADJ
admet-686	168	21	curve	curve	NOUN
admet-686	168	22	is	be	AUX
admet-686	168	23	most	most	ADV
admet-686	168	24	prominent	prominent	ADJ
admet-686	168	25	right	right	ADV
admet-686	168	26	below	below	ADP
admet-686	168	27	the	the	DET
admet-686	168	28	phmax	phmax	NOUN
admet-686	168	29	for	for	ADP
admet-686	168	30	acids	acid	NOUN
admet-686	168	31	and	and	CCONJ
admet-686	168	32	right	right	ADV
admet-686	168	33	above	above	ADP
admet-686	168	34	the	the	DET
admet-686	168	35	phmax	phmax	NOUN
admet-686	168	36	for	for	ADP
admet-686	168	37	bases	basis	NOUN
admet-686	168	38	,	,	PUNCT
admet-686	168	39	as	as	SCONJ
admet-686	168	40	indicated	indicate	VERB
admet-686	168	41	by	by	ADP
admet-686	168	42	the	the	DET
admet-686	168	43	examples	example	NOUN
admet-686	168	44	in	in	ADP
admet-686	168	45	figure	figure	NOUN
admet-686	168	46	5	5	NUM
admet-686	168	47	.	.	PUNCT
admet-686	168	48	admet	admet	PROPN
admet-686	168	49	&	&	CCONJ
admet-686	168	50	dmpk	dmpk	PROPN
admet-686	168	51	7(2	7(2	NUM
admet-686	168	52	)	)	PUNCT
admet-686	168	53	(	(	PUNCT
admet-686	168	54	2019	2019	NUM
admet-686	168	55	)	)	PUNCT
admet-686	168	56	88	88	NUM
admet-686	168	57	-	-	SYM
admet-686	168	58	105	105	NUM
admet-686	168	59	perspectives	perspective	NOUN
admet-686	168	60	in	in	ADP
admet-686	168	61	solubility	solubility	NOUN
admet-686	168	62	measurements	measurement	NOUN
admet-686	168	63	and	and	CCONJ
admet-686	168	64	interpretation	interpretation	NOUN
admet-686	168	65	doi	doi	PROPN
admet-686	168	66	:	:	PUNCT
admet-686	168	67	10.5599	10.5599	NUM
admet-686	168	68	/	/	SYM
admet-686	168	69	admet.686	admet.686	PRON
admet-686	168	70	95	95	NUM
admet-686	168	71	figure	figure	NOUN
admet-686	168	72	5	5	NUM
admet-686	168	73	.	.	PUNCT
admet-686	168	74	examples	example	NOUN
admet-686	168	75	of	of	ADP
admet-686	168	76	charged	charge	VERB
admet-686	168	77	-	-	PUNCT
admet-686	168	78	species	specie	NOUN
admet-686	168	79	aggregation	aggregation	NOUN
admet-686	168	80	.	.	PUNCT
admet-686	169	1	(	(	PUNCT
admet-686	169	2	a	a	X
admet-686	169	3	)	)	PUNCT
admet-686	169	4	brequinar	brequinar	NOUN
admet-686	169	5	appears	appear	VERB
admet-686	169	6	to	to	PART
admet-686	169	7	form	form	VERB
admet-686	169	8	a	a	DET
admet-686	169	9	negatively	negatively	ADV
admet-686	169	10	-	-	PUNCT
admet-686	169	11	charged	charge	VERB
admet-686	169	12	dimer	dimer	NOUN
admet-686	169	13	above	above	ADP
admet-686	169	14	ph	ph	PROPN
admet-686	169	15	7	7	NUM
admet-686	169	16	,	,	PUNCT
admet-686	169	17	as	as	SCONJ
admet-686	169	18	indicated	indicate	VERB
admet-686	169	19	by	by	ADP
admet-686	169	20	a	a	DET
admet-686	169	21	slope	slope	NOUN
admet-686	169	22	of	of	ADP
admet-686	169	23	+2	+2	PROPN
admet-686	169	24	in	in	ADP
admet-686	169	25	the	the	DET
admet-686	169	26	log	log	NOUN
admet-686	169	27	s	s	NOUN
admet-686	169	28	-	-	PUNCT
admet-686	169	29	ph	ph	ADJ
admet-686	169	30	plot	plot	NOUN
admet-686	169	31	.	.	PUNCT
admet-686	170	1	sodium	sodium	NOUN
admet-686	170	2	-	-	PUNCT
admet-686	170	3	drug	drug	NOUN
admet-686	170	4	salt	salt	NOUN
admet-686	170	5	precipitates	precipitate	NOUN
admet-686	170	6	above	above	ADP
admet-686	170	7	ph	ph	NOUN
admet-686	170	8	9	9	NUM
admet-686	170	9	[	[	X
admet-686	170	10	34	34	NUM
admet-686	170	11	]	]	PUNCT
admet-686	170	12	.	.	PUNCT
admet-686	171	1	(	(	PUNCT
admet-686	171	2	b	b	X
admet-686	171	3	)	)	PUNCT
admet-686	171	4	3-(4	3-(4	NUM
admet-686	171	5	-	-	PUNCT
admet-686	171	6	heptyl	heptyl	NOUN
admet-686	171	7	-	-	PUNCT
admet-686	171	8	benzoyl)-benzoic	benzoyl)-benzoic	PROPN
admet-686	171	9	acid	acid	NOUN
admet-686	171	10	appears	appear	VERB
admet-686	171	11	to	to	PART
admet-686	171	12	form	form	VERB
admet-686	171	13	an	an	DET
admet-686	171	14	8	8	NUM
admet-686	171	15	-	-	PUNCT
admet-686	171	16	monomer	monomer	NOUN
admet-686	171	17	aggregate	aggregate	NOUN
admet-686	171	18	above	above	ADP
admet-686	171	19	ph	ph	NOUN
admet-686	171	20	7	7	NUM
admet-686	171	21	,	,	PUNCT
admet-686	171	22	as	as	SCONJ
admet-686	171	23	indicated	indicate	VERB
admet-686	171	24	by	by	ADP
admet-686	171	25	the	the	DET
admet-686	171	26	slope	slope	NOUN
admet-686	171	27	of	of	ADP
admet-686	171	28	+8	+8	PROPN
admet-686	171	29	in	in	ADP
admet-686	171	30	the	the	DET
admet-686	171	31	plot	plot	NOUN
admet-686	171	32	[	[	X
admet-686	171	33	35	35	NUM
admet-686	171	34	]	]	PUNCT
admet-686	171	35	.	.	PUNCT
admet-686	172	1	(	(	PUNCT
admet-686	172	2	c	c	X
admet-686	172	3	)	)	PUNCT
admet-686	172	4	ciprofloxacin	ciprofloxacin	PROPN
admet-686	172	5	cation	cation	NOUN
admet-686	172	6	appears	appear	VERB
admet-686	172	7	to	to	PART
admet-686	172	8	form	form	VERB
admet-686	172	9	a	a	DET
admet-686	172	10	pentameric	pentameric	NOUN
admet-686	172	11	aggregate	aggregate	NOUN
admet-686	172	12	below	below	ADP
admet-686	172	13	ph	ph	NOUN
admet-686	172	14	6	6	NUM
admet-686	172	15	,	,	PUNCT
admet-686	172	16	as	as	ADV
admet-686	172	17	well	well	ADV
admet-686	172	18	as	as	ADP
admet-686	172	19	a	a	DET
admet-686	172	20	phosphate	phosphate	ADJ
admet-686	172	21	salt	salt	NOUN
admet-686	172	22	for	for	ADP
admet-686	172	23	ph	ph	NOUN
admet-686	172	24	<	<	X
admet-686	172	25	phmax	phmax	NOUN
admet-686	173	1	[	[	X
admet-686	173	2	36	36	NUM
admet-686	173	3	]	]	PUNCT
admet-686	173	4	.	.	PUNCT
admet-686	174	1	the	the	DET
admet-686	174	2	possibility	possibility	NOUN
admet-686	174	3	of	of	ADP
admet-686	174	4	drug	drug	NOUN
admet-686	174	5	-	-	PUNCT
admet-686	174	6	phosphate	phosphate	NOUN
admet-686	174	7	complexation	complexation	NOUN
admet-686	174	8	has	have	AUX
admet-686	174	9	not	not	PART
admet-686	174	10	been	be	AUX
admet-686	174	11	ruled	rule	VERB
admet-686	174	12	out	out	ADP
admet-686	174	13	.	.	PUNCT
admet-686	175	1	as	as	SCONJ
admet-686	175	2	discussed	discuss	VERB
admet-686	175	3	by	by	ADP
admet-686	175	4	gebauer	gebauer	PROPN
admet-686	175	5	et	et	PROPN
admet-686	175	6	al	al	PROPN
admet-686	175	7	.	.	PUNCT
admet-686	176	1	[	[	X
admet-686	176	2	31	31	NUM
admet-686	176	3	]	]	PUNCT
admet-686	176	4	,	,	PUNCT
admet-686	176	5	amino	amino	NOUN
admet-686	176	6	acids	acid	NOUN
admet-686	176	7	,	,	PUNCT
admet-686	176	8	particularly	particularly	ADV
admet-686	176	9	glycine	glycine	NOUN
admet-686	176	10	,	,	PUNCT
admet-686	176	11	form	form	VERB
admet-686	176	12	sub	sub	ADJ
admet-686	176	13	-	-	ADJ
admet-686	176	14	micellar	micellar	ADJ
admet-686	176	15	pre	pre	ADJ
admet-686	176	16	-	-	ADJ
admet-686	176	17	nucleation	nucleation	ADJ
admet-686	176	18	clusters	cluster	NOUN
admet-686	176	19	.	.	PUNCT
admet-686	177	1	figure	figure	NOUN
admet-686	177	2	6	6	NUM
admet-686	177	3	displays	display	NOUN
admet-686	177	4	log	log	VERB
admet-686	177	5	s	s	ADJ
admet-686	177	6	-	-	PUNCT
admet-686	177	7	ph	ph	ADJ
admet-686	177	8	profiles	profile	NOUN
admet-686	177	9	of	of	ADP
admet-686	177	10	six	six	NUM
admet-686	177	11	amino	amino	ADJ
admet-686	177	12	acids	acid	NOUN
admet-686	177	13	in	in	ADP
admet-686	177	14	buffer	buffer	NOUN
admet-686	177	15	-	-	PUNCT
admet-686	177	16	free	free	ADJ
admet-686	177	17	solutions	solution	NOUN
admet-686	177	18	,	,	PUNCT
admet-686	177	19	where	where	SCONJ
admet-686	177	20	ph	ph	PROPN
admet-686	177	21	was	be	AUX
admet-686	177	22	modified	modify	VERB
admet-686	177	23	with	with	ADP
admet-686	177	24	hcl	hcl	PROPN
admet-686	177	25	/	/	SYM
admet-686	177	26	naoh	naoh	PROPN
admet-686	177	27	[	[	X
admet-686	177	28	37	37	NUM
admet-686	177	29	-	-	SYM
admet-686	177	30	39	39	NUM
admet-686	177	31	]	]	PUNCT
admet-686	177	32	.	.	PUNCT
admet-686	178	1	amino	amino	ADJ
admet-686	178	2	acids	acid	NOUN
admet-686	178	3	are	be	AUX
admet-686	178	4	highly	highly	ADV
admet-686	178	5	soluble	soluble	ADJ
admet-686	178	6	in	in	ADP
admet-686	178	7	water	water	NOUN
admet-686	178	8	.	.	PUNCT
admet-686	179	1	consequently	consequently	ADV
admet-686	179	2	,	,	PUNCT
admet-686	179	3	the	the	DET
admet-686	179	4	ionic	ionic	ADJ
admet-686	179	5	strength	strength	NOUN
admet-686	179	6	reaches	reach	VERB
admet-686	179	7	nearly	nearly	ADV
admet-686	179	8	5	5	NUM
admet-686	179	9	m	m	NOUN
admet-686	179	10	at	at	ADP
admet-686	179	11	the	the	DET
admet-686	179	12	low	low	ADJ
admet-686	179	13	-	-	PUNCT
admet-686	179	14	ph	ph	ADJ
admet-686	179	15	end	end	NOUN
admet-686	179	16	of	of	ADP
admet-686	179	17	the	the	DET
admet-686	179	18	profile	profile	NOUN
admet-686	179	19	in	in	ADP
admet-686	179	20	three	three	NUM
admet-686	179	21	of	of	ADP
admet-686	179	22	the	the	DET
admet-686	179	23	cases	case	NOUN
admet-686	179	24	.	.	PUNCT
admet-686	180	1	the	the	DET
admet-686	180	2	ph	ph	NOUN
admet-686	180	3	<	<	X
admet-686	180	4	3	3	NUM
admet-686	180	5	and	and	CCONJ
admet-686	180	6	ph	ph	ADJ
admet-686	180	7	>	>	SYM
admet-686	180	8	9	9	NUM
admet-686	180	9	electrode	electrode	NOUN
admet-686	180	10	readings	reading	NOUN
admet-686	180	11	may	may	AUX
admet-686	180	12	be	be	AUX
admet-686	180	13	significantly	significantly	ADV
admet-686	180	14	affected	affect	VERB
admet-686	180	15	.	.	PUNCT
admet-686	181	1	the	the	DET
admet-686	181	2	symmetrically	symmetrically	ADV
admet-686	181	3	u	u	NOUN
admet-686	181	4	-	-	VERB
admet-686	181	5	shaped	shape	VERB
admet-686	181	6	dashed	dash	VERB
admet-686	181	7	curves	curve	NOUN
admet-686	181	8	in	in	ADP
admet-686	181	9	the	the	DET
admet-686	181	10	figures	figure	NOUN
admet-686	181	11	were	be	AUX
admet-686	181	12	calculated	calculate	VERB
admet-686	181	13	using	use	VERB
admet-686	181	14	the	the	DET
admet-686	181	15	simple	simple	ADJ
admet-686	181	16	hh	hh	ADJ
admet-686	181	17	equation	equation	NOUN
admet-686	181	18	,	,	PUNCT
admet-686	181	19	which	which	PRON
admet-686	181	20	does	do	AUX
admet-686	181	21	not	not	PART
admet-686	181	22	factor	factor	VERB
admet-686	181	23	in	in	ADP
admet-686	181	24	the	the	DET
admet-686	181	25	effects	effect	NOUN
admet-686	181	26	of	of	ADP
admet-686	181	27	ionic	ionic	ADJ
admet-686	181	28	strength	strength	NOUN
admet-686	181	29	.	.	PUNCT
admet-686	182	1	the	the	DET
admet-686	182	2	solid	solid	ADJ
admet-686	182	3	curves	curve	NOUN
admet-686	182	4	,	,	PUNCT
admet-686	182	5	which	which	PRON
admet-686	182	6	are	be	AUX
admet-686	182	7	less	less	ADV
admet-686	182	8	symmetrical	symmetrical	ADJ
admet-686	182	9	than	than	ADP
admet-686	182	10	the	the	DET
admet-686	182	11	hh	hh	ADJ
admet-686	182	12	curves	curve	NOUN
admet-686	182	13	,	,	PUNCT
admet-686	182	14	are	be	AUX
admet-686	182	15	the	the	DET
admet-686	182	16	results	result	NOUN
admet-686	182	17	of	of	ADP
admet-686	182	18	regression	regression	NOUN
admet-686	182	19	analysis	analysis	NOUN
admet-686	182	20	where	where	SCONJ
admet-686	182	21	effects	effect	NOUN
admet-686	182	22	of	of	ADP
admet-686	182	23	ionic	ionic	ADJ
admet-686	182	24	strength	strength	NOUN
admet-686	182	25	were	be	AUX
admet-686	182	26	factored	factor	VERB
admet-686	182	27	in	in	ADP
admet-686	182	28	[	[	X
admet-686	182	29	22	22	NUM
admet-686	182	30	]	]	PUNCT
admet-686	182	31	.	.	PUNCT
admet-686	183	1	the	the	DET
admet-686	183	2	apparent	apparent	ADJ
admet-686	183	3	log	log	NOUN
admet-686	183	4	s0	s0	NOUN
admet-686	183	5	values	value	NOUN
admet-686	183	6	listed	list	VERB
admet-686	183	7	in	in	ADP
admet-686	183	8	the	the	DET
admet-686	183	9	figures	figure	NOUN
admet-686	183	10	were	be	AUX
admet-686	183	11	calculated	calculate	VERB
admet-686	183	12	using	use	VERB
admet-686	183	13	only	only	ADV
admet-686	183	14	the	the	DET
admet-686	183	15	data	datum	NOUN
admet-686	183	16	in	in	ADP
admet-686	183	17	the	the	DET
admet-686	183	18	ph	ph	ADJ
admet-686	183	19	4	4	NUM
admet-686	183	20	-	-	SYM
admet-686	183	21	8	8	NUM
admet-686	183	22	interval	interval	NOUN
admet-686	183	23	,	,	PUNCT
admet-686	183	24	with	with	ADP
admet-686	183	25	the	the	DET
admet-686	183	26	rest	rest	NOUN
admet-686	183	27	of	of	ADP
admet-686	183	28	the	the	DET
admet-686	183	29	points	point	NOUN
admet-686	183	30	assigned	assign	VERB
admet-686	183	31	zero	zero	NUM
admet-686	183	32	weights	weight	NOUN
admet-686	183	33	during	during	ADP
admet-686	183	34	the	the	DET
admet-686	183	35	regression	regression	NOUN
admet-686	183	36	analysis	analysis	NOUN
admet-686	183	37	.	.	PUNCT
admet-686	184	1	it	it	PRON
admet-686	184	2	can	can	AUX
admet-686	184	3	be	be	AUX
admet-686	184	4	seen	see	VERB
admet-686	184	5	that	that	SCONJ
admet-686	184	6	for	for	ADP
admet-686	184	7	ph	ph	NOUN
admet-686	184	8	<	<	X
admet-686	184	9	3	3	NUM
admet-686	184	10	and	and	CCONJ
admet-686	184	11	ph	ph	NOUN
admet-686	184	12	>	>	X
admet-686	184	13	9	9	NUM
admet-686	184	14	,	,	PUNCT
admet-686	184	15	the	the	DET
admet-686	184	16	measured	measure	VERB
admet-686	184	17	points	point	NOUN
admet-686	184	18	are	be	AUX
admet-686	184	19	notably	notably	ADV
admet-686	184	20	below	below	ADP
admet-686	184	21	the	the	DET
admet-686	184	22	solid	solid	ADJ
admet-686	184	23	curves	curve	NOUN
admet-686	184	24	.	.	PUNCT
admet-686	185	1	this	this	PRON
admet-686	185	2	is	be	AUX
admet-686	185	3	extremely	extremely	ADV
admet-686	185	4	so	so	ADV
admet-686	185	5	in	in	ADP
admet-686	185	6	the	the	DET
admet-686	185	7	case	case	NOUN
admet-686	185	8	of	of	ADP
admet-686	185	9	glycine	glycine	NOUN
admet-686	185	10	in	in	ADP
admet-686	185	11	figure	figure	NOUN
admet-686	185	12	6b	6b	NOUN
admet-686	185	13	.	.	PUNCT
admet-686	186	1	ordinarily	ordinarily	ADV
admet-686	186	2	,	,	PUNCT
admet-686	186	3	such	such	ADJ
admet-686	186	4	distortion	distortion	NOUN
admet-686	186	5	would	would	AUX
admet-686	186	6	suggest	suggest	VERB
admet-686	186	7	that	that	SCONJ
admet-686	186	8	the	the	DET
admet-686	186	9	zwitterionic	zwitterionic	ADJ
admet-686	186	10	form	form	NOUN
admet-686	186	11	of	of	ADP
admet-686	186	12	the	the	DET
admet-686	186	13	molecules	molecule	NOUN
admet-686	186	14	self	self	NOUN
admet-686	186	15	-	-	PUNCT
admet-686	186	16	associate	associate	NOUN
admet-686	186	17	,	,	PUNCT
admet-686	186	18	thus	thus	ADV
admet-686	186	19	raising	raise	VERB
admet-686	186	20	the	the	DET
admet-686	186	21	solubility	solubility	NOUN
admet-686	186	22	[	[	X
admet-686	186	23	28	28	NUM
admet-686	186	24	]	]	PUNCT
admet-686	186	25	.	.	PUNCT
admet-686	187	1	however	however	ADV
admet-686	187	2	,	,	PUNCT
admet-686	187	3	it	it	PRON
admet-686	187	4	was	be	AUX
admet-686	187	5	not	not	PART
admet-686	187	6	possible	possible	ADJ
admet-686	187	7	to	to	PART
admet-686	187	8	fit	fit	VERB
admet-686	187	9	the	the	DET
admet-686	187	10	glycine	glycine	NOUN
admet-686	187	11	data	datum	NOUN
admet-686	187	12	with	with	ADP
admet-686	187	13	an	an	DET
admet-686	187	14	aggregation	aggregation	NOUN
admet-686	187	15	model	model	NOUN
admet-686	187	16	that	that	PRON
admet-686	187	17	contained	contain	VERB
admet-686	187	18	a	a	DET
admet-686	187	19	single	single	ADJ
admet-686	187	20	zwitterionic	zwitterionic	ADJ
admet-686	187	21	stoichiometry	stoichiometry	NOUN
admet-686	187	22	.	.	PUNCT
admet-686	188	1	at	at	ADP
admet-686	188	2	least	least	ADJ
admet-686	188	3	several	several	ADJ
admet-686	188	4	overlapping	overlap	VERB
admet-686	188	5	oligomers	oligomer	NOUN
admet-686	188	6	appear	appear	VERB
admet-686	188	7	to	to	PART
admet-686	188	8	be	be	AUX
admet-686	188	9	necessary	necessary	ADJ
admet-686	188	10	to	to	PART
admet-686	188	11	rationalize	rationalize	VERB
admet-686	188	12	the	the	DET
admet-686	188	13	nearly	nearly	ADV
admet-686	188	14	flat	flat	ADJ
admet-686	188	15	log	log	NOUN
admet-686	188	16	s	s	NOUN
admet-686	188	17	-	-	PUNCT
admet-686	188	18	ph	ph	ADJ
admet-686	188	19	profile	profile	NOUN
admet-686	188	20	of	of	ADP
admet-686	188	21	polymeric	polymeric	ADJ
admet-686	188	22	glycine	glycine	NOUN
admet-686	188	23	.	.	PUNCT
admet-686	189	1	it	it	PRON
admet-686	189	2	may	may	AUX
admet-686	189	3	be	be	AUX
admet-686	189	4	that	that	SCONJ
admet-686	189	5	glycine	glycine	NOUN
admet-686	189	6	forms	form	VERB
admet-686	189	7	a	a	DET
admet-686	189	8	high	high	ADJ
admet-686	189	9	-	-	PUNCT
admet-686	189	10	molecular	molecular	ADJ
admet-686	189	11	weight	weight	NOUN
admet-686	189	12	polymer	polymer	NOUN
admet-686	189	13	strands	strand	NOUN
admet-686	189	14	in	in	ADP
admet-686	189	15	saturated	saturated	ADJ
admet-686	189	16	solutions	solution	NOUN
admet-686	189	17	,	,	PUNCT
admet-686	189	18	which	which	PRON
admet-686	189	19	persist	persist	VERB
admet-686	189	20	across	across	ADP
admet-686	189	21	a	a	DET
admet-686	189	22	broad	broad	ADJ
admet-686	189	23	swathe	swathe	NOUN
admet-686	189	24	of	of	ADP
admet-686	189	25	ph	ph	PROPN
admet-686	189	26	.	.	PROPN
admet-686	189	27	hydrotropic	hydrotropic	PROPN
admet-686	189	28	solubilization	solubilization	NOUN
admet-686	189	29	via	via	ADP
admet-686	189	30	cluster	cluster	NOUN
admet-686	189	31	formation	formation	NOUN
admet-686	189	32	in	in	ADP
admet-686	189	33	1916	1916	NUM
admet-686	189	34	,	,	PUNCT
admet-686	189	35	neuberg	neuberg	PROPN
admet-686	190	1	[	[	X
admet-686	190	2	40	40	NUM
admet-686	190	3	]	]	PUNCT
admet-686	190	4	coined	coin	VERB
admet-686	190	5	the	the	DET
admet-686	190	6	term	term	NOUN
admet-686	190	7	‘	'	PUNCT
admet-686	190	8	hydrotrope	hydrotrope	NOUN
admet-686	190	9	’	'	PUNCT
admet-686	190	10	for	for	ADP
admet-686	190	11	compounds	compound	NOUN
admet-686	190	12	that	that	PRON
admet-686	190	13	increase	increase	VERB
admet-686	190	14	the	the	DET
admet-686	190	15	solubility	solubility	NOUN
admet-686	190	16	of	of	ADP
admet-686	190	17	sparingly	sparingly	ADV
admet-686	190	18	-	-	PUNCT
admet-686	190	19	soluble	soluble	ADJ
admet-686	190	20	organic	organic	ADJ
admet-686	190	21	substances	substance	NOUN
admet-686	190	22	,	,	PUNCT
admet-686	190	23	by	by	ADP
admet-686	190	24	interacting	interact	VERB
admet-686	190	25	as	as	ADP
admet-686	190	26	‘	'	PUNCT
admet-686	190	27	co	co	NOUN
admet-686	190	28	-	-	NOUN
admet-686	190	29	solubilizers	solubilizer	NOUN
admet-686	190	30	.	.	PUNCT
admet-686	190	31	’	'	PUNCT
admet-686	191	1	usually	usually	ADV
admet-686	191	2	,	,	PUNCT
admet-686	191	3	high	high	ADJ
admet-686	191	4	concentrations	concentration	NOUN
admet-686	191	5	of	of	ADP
admet-686	191	6	hydrotropes	hydrotrope	NOUN
admet-686	191	7	are	be	AUX
admet-686	191	8	necessary	necessary	ADJ
admet-686	191	9	to	to	PART
admet-686	191	10	increase	increase	VERB
admet-686	191	11	solubility	solubility	NOUN
admet-686	191	12	of	of	ADP
admet-686	191	13	the	the	DET
admet-686	191	14	sparingly	sparingly	ADV
admet-686	191	15	-	-	PUNCT
admet-686	191	16	soluble	soluble	ADJ
admet-686	191	17	substance	substance	NOUN
admet-686	191	18	.	.	PUNCT
admet-686	192	1	hydrotropes	hydrotrope	NOUN
admet-686	192	2	are	be	AUX
admet-686	192	3	thought	think	VERB
admet-686	192	4	to	to	PART
admet-686	192	5	form	form	VERB
admet-686	192	6	aggregates	aggregate	NOUN
admet-686	192	7	in	in	ADP
admet-686	192	8	solution	solution	NOUN
admet-686	192	9	.	.	PUNCT
admet-686	193	1	typical	typical	ADJ
admet-686	193	2	examples	example	NOUN
admet-686	193	3	of	of	ADP
admet-686	193	4	hydrotropes	hydrotrope	NOUN
admet-686	193	5	include	include	VERB
admet-686	193	6	urea	urea	NOUN
admet-686	193	7	,	,	PUNCT
admet-686	193	8	nicotinamide	nicotinamide	NOUN
admet-686	193	9	,	,	PUNCT
admet-686	193	10	bergström	bergström	NOUN
admet-686	193	11	and	and	CCONJ
admet-686	193	12	avdeef	avdeef	PROPN
admet-686	193	13	admet	admet	PROPN
admet-686	193	14	&	&	CCONJ
admet-686	193	15	dmpk	dmpk	PROPN
admet-686	193	16	7(2	7(2	NUM
admet-686	193	17	)	)	PUNCT
admet-686	193	18	(	(	PUNCT
admet-686	193	19	2019	2019	NUM
admet-686	193	20	)	)	PUNCT
admet-686	193	21	88	88	NUM
admet-686	193	22	-	-	SYM
admet-686	193	23	105	105	NUM
admet-686	193	24	96	96	NUM
admet-686	193	25	sodium	sodium	NOUN
admet-686	193	26	salicylate	salicylate	NOUN
admet-686	193	27	,	,	PUNCT
admet-686	193	28	and	and	CCONJ
admet-686	193	29	benzoates	benzoate	VERB
admet-686	193	30	with	with	ADP
admet-686	193	31	a	a	DET
admet-686	193	32	short	short	ADJ
admet-686	193	33	alkyl	alkyl	NOUN
admet-686	193	34	chains	chain	NOUN
admet-686	193	35	,	,	PUNCT
admet-686	193	36	as	as	SCONJ
admet-686	193	37	these	these	DET
admet-686	193	38	molecules	molecule	NOUN
admet-686	193	39	can	can	AUX
admet-686	193	40	self	self	NOUN
admet-686	193	41	-	-	PUNCT
admet-686	193	42	associate	associate	NOUN
admet-686	193	43	into	into	ADP
admet-686	193	44	small	small	ADJ
admet-686	193	45	,	,	PUNCT
admet-686	193	46	sub	sub	ADJ
admet-686	193	47	-	-	ADJ
admet-686	193	48	micellar	micellar	ADJ
admet-686	193	49	clusters	cluster	NOUN
admet-686	193	50	of	of	ADP
admet-686	193	51	3	3	NUM
admet-686	193	52	-	-	SYM
admet-686	193	53	4	4	NUM
admet-686	193	54	molecules	molecule	NOUN
admet-686	193	55	[	[	X
admet-686	193	56	41	41	NUM
admet-686	193	57	]	]	PUNCT
admet-686	193	58	.	.	PUNCT
admet-686	194	1	a	a	DET
admet-686	194	2	poorly	poorly	ADV
admet-686	194	3	-	-	PUNCT
admet-686	194	4	soluble	soluble	ADJ
admet-686	194	5	molecule	molecule	NOUN
admet-686	194	6	can	can	AUX
admet-686	194	7	be	be	AUX
admet-686	194	8	associated	associate	VERB
admet-686	194	9	with	with	ADP
admet-686	194	10	these	these	DET
admet-686	194	11	clusters	cluster	NOUN
admet-686	194	12	and	and	CCONJ
admet-686	194	13	become	become	VERB
admet-686	194	14	solubilized	solubilize	VERB
admet-686	194	15	in	in	ADP
admet-686	194	16	the	the	DET
admet-686	194	17	process	process	NOUN
admet-686	194	18	.	.	PUNCT
admet-686	195	1	figure	figure	NOUN
admet-686	195	2	7	7	NUM
admet-686	195	3	shows	show	VERB
admet-686	195	4	an	an	DET
admet-686	195	5	example	example	NOUN
admet-686	195	6	of	of	ADP
admet-686	195	7	the	the	DET
admet-686	195	8	hydrotropic	hydrotropic	ADJ
admet-686	195	9	solubilization	solubilization	NOUN
admet-686	195	10	of	of	ADP
admet-686	195	11	medazepam	medazepam	NOUN
admet-686	195	12	by	by	ADP
admet-686	195	13	salicylate	salicylate	NOUN
admet-686	195	14	anions	anion	NOUN
admet-686	195	15	[	[	X
admet-686	195	16	42	42	NUM
admet-686	195	17	]	]	PUNCT
admet-686	195	18	.	.	PUNCT
admet-686	196	1	it	it	PRON
admet-686	196	2	would	would	AUX
admet-686	196	3	be	be	AUX
admet-686	196	4	interesting	interesting	ADJ
admet-686	196	5	to	to	PART
admet-686	196	6	explore	explore	VERB
admet-686	196	7	whether	whether	SCONJ
admet-686	196	8	phosphate	phosphate	ADJ
admet-686	196	9	at	at	ADP
admet-686	196	10	high	high	ADJ
admet-686	196	11	concentrations	concentration	NOUN
admet-686	196	12	acts	act	VERB
admet-686	196	13	as	as	ADP
admet-686	196	14	a	a	DET
admet-686	196	15	hydrotrope	hydrotrope	NOUN
admet-686	196	16	.	.	PUNCT
admet-686	197	1	figure	figure	NOUN
admet-686	197	2	6	6	NUM
admet-686	197	3	.	.	PUNCT
admet-686	198	1	the	the	DET
admet-686	198	2	solubility	solubility	NOUN
admet-686	198	3	-	-	PUNCT
admet-686	198	4	ph	ph	ADJ
admet-686	198	5	profiles	profile	NOUN
admet-686	198	6	of	of	ADP
admet-686	198	7	amino	amino	ADJ
admet-686	198	8	acids	acid	NOUN
admet-686	198	9	showing	show	VERB
admet-686	198	10	departures	departure	NOUN
admet-686	198	11	from	from	ADP
admet-686	198	12	the	the	DET
admet-686	198	13	ideal	ideal	ADJ
admet-686	198	14	henderson	henderson	PROPN
admet-686	198	15	-	-	PUNCT
admet-686	198	16	hasselbalch	hasselbalch	PROPN
admet-686	198	17	shape	shape	NOUN
admet-686	198	18	.	.	PUNCT
admet-686	199	1	the	the	DET
admet-686	199	2	distortion	distortion	NOUN
admet-686	199	3	is	be	AUX
admet-686	199	4	particularly	particularly	ADV
admet-686	199	5	extreme	extreme	ADJ
admet-686	199	6	in	in	ADP
admet-686	199	7	the	the	DET
admet-686	199	8	case	case	NOUN
admet-686	199	9	of	of	ADP
admet-686	199	10	glycine	glycine	NOUN
admet-686	199	11	.	.	PUNCT
admet-686	200	1	since	since	SCONJ
admet-686	200	2	the	the	DET
admet-686	200	3	data	datum	NOUN
admet-686	200	4	for	for	ADP
admet-686	200	5	ph	ph	NOUN
admet-686	200	6	<	<	X
admet-686	200	7	4	4	NUM
admet-686	200	8	and	and	CCONJ
admet-686	200	9	ph	ph	VERB
admet-686	200	10	>	>	SYM
admet-686	200	11	8	8	NUM
admet-686	200	12	were	be	AUX
admet-686	200	13	not	not	PART
admet-686	200	14	used	use	VERB
admet-686	200	15	in	in	ADP
admet-686	200	16	the	the	DET
admet-686	200	17	regression	regression	NOUN
admet-686	200	18	analysis	analysis	NOUN
admet-686	200	19	,	,	PUNCT
admet-686	200	20	the	the	DET
admet-686	200	21	listed	list	VERB
admet-686	200	22	log	log	NOUN
admet-686	200	23	s0	s0	PROPN
admet-686	200	24	values	value	NOUN
admet-686	200	25	are	be	AUX
admet-686	200	26	‘	'	PUNCT
admet-686	200	27	apparent	apparent	ADJ
admet-686	200	28	.	.	PUNCT
admet-686	200	29	’	'	PUNCT
admet-686	201	1	the	the	DET
admet-686	201	2	actual	actual	ADJ
admet-686	201	3	values	value	NOUN
admet-686	201	4	may	may	AUX
admet-686	201	5	be	be	AUX
admet-686	201	6	lower	low	ADJ
admet-686	201	7	,	,	PUNCT
admet-686	201	8	especially	especially	ADV
admet-686	201	9	for	for	ADP
admet-686	201	10	glycine	glycine	NOUN
admet-686	201	11	.	.	PUNCT
admet-686	202	1	figure	figure	NOUN
admet-686	202	2	7	7	NUM
admet-686	202	3	.	.	PUNCT
admet-686	202	4	hydrotropic	hydrotropic	NOUN
admet-686	202	5	solubilization	solubilization	NOUN
admet-686	202	6	.	.	PUNCT
admet-686	203	1	plot	plot	NOUN
admet-686	203	2	of	of	ADP
admet-686	203	3	the	the	DET
admet-686	203	4	total	total	ADJ
admet-686	203	5	concentration	concentration	NOUN
admet-686	203	6	of	of	ADP
admet-686	203	7	medazepam	medazepam	NOUN
admet-686	203	8	in	in	ADP
admet-686	203	9	a	a	DET
admet-686	203	10	saturated	saturate	VERB
admet-686	203	11	solution	solution	NOUN
admet-686	203	12	as	as	ADP
admet-686	203	13	a	a	DET
admet-686	203	14	function	function	NOUN
admet-686	203	15	of	of	ADP
admet-686	203	16	added	add	VERB
admet-686	203	17	sodium	sodium	NOUN
admet-686	203	18	salicylate	salicylate	NOUN
admet-686	203	19	.	.	PUNCT
admet-686	204	1	the	the	DET
admet-686	204	2	solubility	solubility	NOUN
admet-686	204	3	data	datum	NOUN
admet-686	204	4	of	of	ADP
admet-686	204	5	badwan	badwan	PROPN
admet-686	204	6	et	et	PROPN
admet-686	204	7	al	al	PROPN
admet-686	204	8	.	.	PUNCT
admet-686	205	1	[	[	X
admet-686	205	2	42	42	NUM
admet-686	205	3	]	]	PUNCT
admet-686	205	4	were	be	AUX
admet-686	205	5	fit	fit	ADJ
admet-686	205	6	(	(	PUNCT
admet-686	205	7	using	use	VERB
admet-686	205	8	pdisol	pdisol	ADJ
admet-686	205	9	-	-	PUNCT
admet-686	205	10	x	x	NOUN
admet-686	205	11	)	)	PUNCT
admet-686	205	12	to	to	ADP
admet-686	205	13	an	an	DET
admet-686	205	14	equilibrium	equilibrium	NOUN
admet-686	205	15	model	model	NOUN
admet-686	205	16	consisting	consist	VERB
admet-686	205	17	of	of	ADP
admet-686	205	18	the	the	DET
admet-686	205	19	drug	drug	NOUN
admet-686	205	20	forming	form	VERB
admet-686	205	21	a	a	DET
admet-686	205	22	complex	complex	NOUN
admet-686	205	23	with	with	ADP
admet-686	205	24	four	four	NUM
admet-686	205	25	units	unit	NOUN
admet-686	205	26	of	of	ADP
admet-686	205	27	salicylate	salicylate	NOUN
admet-686	205	28	.	.	PUNCT
admet-686	206	1	‘	'	PUNCT
admet-686	206	2	cac	cac	PROPN
admet-686	206	3	’	'	PUNCT
admet-686	206	4	is	be	AUX
admet-686	206	5	the	the	DET
admet-686	206	6	abbreviation	abbreviation	NOUN
admet-686	206	7	for	for	ADP
admet-686	206	8	critical	critical	ADJ
admet-686	206	9	aggregate	aggregate	ADJ
admet-686	206	10	concentration	concentration	NOUN
admet-686	206	11	.	.	PUNCT
admet-686	207	1	admet	admet	PROPN
admet-686	207	2	&	&	CCONJ
admet-686	207	3	dmpk	dmpk	PROPN
admet-686	207	4	7(2	7(2	NUM
admet-686	207	5	)	)	PUNCT
admet-686	207	6	(	(	PUNCT
admet-686	207	7	2019	2019	NUM
admet-686	207	8	)	)	PUNCT
admet-686	207	9	88	88	NUM
admet-686	207	10	-	-	SYM
admet-686	207	11	105	105	NUM
admet-686	207	12	perspectives	perspective	NOUN
admet-686	207	13	in	in	ADP
admet-686	207	14	solubility	solubility	NOUN
admet-686	207	15	measurements	measurement	NOUN
admet-686	207	16	and	and	CCONJ
admet-686	207	17	interpretation	interpretation	NOUN
admet-686	207	18	doi	doi	PROPN
admet-686	207	19	:	:	PUNCT
admet-686	207	20	10.5599	10.5599	NUM
admet-686	207	21	/	/	SYM
admet-686	207	22	admet.686	admet.686	PROPN
admet-686	207	23	97	97	NUM
admet-686	207	24	supersolubilization	supersolubilization	NOUN
admet-686	207	25	and	and	CCONJ
admet-686	207	26	amorphous	amorphous	ADJ
admet-686	207	27	dispersions	dispersion	NOUN
admet-686	207	28	parikh	parikh	NOUN
admet-686	207	29	and	and	CCONJ
admet-686	207	30	serajuddin	serajuddin	VERB
admet-686	208	1	[	[	X
admet-686	208	2	43	43	NUM
admet-686	208	3	]	]	PUNCT
admet-686	208	4	have	have	AUX
admet-686	208	5	developed	develop	VERB
admet-686	208	6	a	a	DET
admet-686	208	7	novel	novel	ADJ
admet-686	208	8	method	method	NOUN
admet-686	208	9	of	of	ADP
admet-686	208	10	preparing	prepare	VERB
admet-686	208	11	solid	solid	ADJ
admet-686	208	12	dispersion	dispersion	NOUN
admet-686	208	13	by	by	ADP
admet-686	208	14	using	use	VERB
admet-686	208	15	acid	acid	NOUN
admet-686	208	16	-	-	PUNCT
admet-686	208	17	base	base	NOUN
admet-686	208	18	interaction	interaction	NOUN
admet-686	208	19	in	in	ADP
admet-686	208	20	water	water	NOUN
admet-686	208	21	.	.	PUNCT
admet-686	209	1	haloperidol	haloperidol	PROPN
admet-686	209	2	was	be	AUX
admet-686	209	3	dissolved	dissolve	VERB
admet-686	209	4	in	in	ADP
admet-686	209	5	concentrated	concentrated	ADJ
admet-686	209	6	aqueous	aqueous	ADJ
admet-686	209	7	solutions	solution	NOUN
admet-686	209	8	of	of	ADP
admet-686	209	9	a	a	DET
admet-686	209	10	weak	weak	ADJ
admet-686	209	11	acid	acid	NOUN
admet-686	209	12	(	(	PUNCT
admet-686	209	13	e.g.	e.g.	ADV
admet-686	209	14	,	,	PUNCT
admet-686	209	15	malic	malic	ADJ
admet-686	209	16	,	,	PUNCT
admet-686	209	17	tartaric	tartaric	ADJ
admet-686	209	18	,	,	PUNCT
admet-686	209	19	or	or	CCONJ
admet-686	209	20	citric	citric	ADJ
admet-686	209	21	acid	acid	NOUN
admet-686	209	22	)	)	PUNCT
admet-686	209	23	.	.	PUNCT
admet-686	210	1	each	each	DET
admet-686	210	2	weak	weak	ADJ
admet-686	210	3	acid	acid	NOUN
admet-686	210	4	was	be	AUX
admet-686	210	5	selected	select	VERB
admet-686	210	6	such	such	ADJ
admet-686	210	7	that	that	SCONJ
admet-686	210	8	it	it	PRON
admet-686	210	9	would	would	AUX
admet-686	210	10	not	not	PART
admet-686	210	11	form	form	VERB
admet-686	210	12	salts	salt	NOUN
admet-686	210	13	with	with	ADP
admet-686	210	14	the	the	DET
admet-686	210	15	drug	drug	NOUN
admet-686	210	16	.	.	PUNCT
admet-686	211	1	the	the	DET
admet-686	211	2	solubility	solubility	NOUN
admet-686	211	3	of	of	ADP
admet-686	211	4	haloperidol	haloperidol	PROPN
admet-686	211	5	exceeded	exceed	VERB
admet-686	211	6	300	300	NUM
admet-686	211	7	mg	mg	PROPN
admet-686	211	8	/	/	SYM
admet-686	211	9	g	g	NOUN
admet-686	211	10	aqueous	aqueous	ADJ
admet-686	211	11	solution	solution	NOUN
admet-686	211	12	of	of	ADP
admet-686	211	13	malic	malic	ADJ
admet-686	211	14	acid	acid	NOUN
admet-686	211	15	.	.	PUNCT
admet-686	212	1	this	this	PRON
admet-686	212	2	was	be	AUX
admet-686	212	3	an	an	DET
admet-686	212	4	extremely	extremely	ADV
admet-686	212	5	high	high	ADJ
admet-686	212	6	aqueous	aqueous	ADJ
admet-686	212	7	solubility	solubility	NOUN
admet-686	212	8	for	for	ADP
admet-686	212	9	haloperidol	haloperidol	NOUN
admet-686	212	10	,	,	PUNCT
admet-686	212	11	considering	consider	VERB
admet-686	212	12	that	that	SCONJ
admet-686	212	13	its	its	PRON
admet-686	212	14	intrinsic	intrinsic	ADJ
admet-686	212	15	aqueous	aqueous	ADJ
admet-686	212	16	solubility	solubility	NOUN
admet-686	212	17	in	in	ADP
admet-686	212	18	water	water	NOUN
admet-686	212	19	as	as	SCONJ
admet-686	212	20	the	the	DET
admet-686	212	21	free	free	ADJ
admet-686	212	22	base	base	NOUN
admet-686	212	23	is	be	AUX
admet-686	212	24	only	only	ADV
admet-686	212	25	0.7	0.7	NUM
admet-686	212	26	μg	μg	NOUN
admet-686	212	27	/	/	SYM
admet-686	212	28	ml	ml	PROPN
admet-686	212	29	,	,	PUNCT
admet-686	212	30	and	and	CCONJ
admet-686	212	31	the	the	DET
admet-686	212	32	solubility	solubility	NOUN
admet-686	212	33	of	of	ADP
admet-686	212	34	its	its	PRON
admet-686	212	35	salt	salt	NOUN
admet-686	212	36	forms	form	NOUN
admet-686	212	37	(	(	PUNCT
admet-686	212	38	e.g.	e.g.	ADV
admet-686	212	39	,	,	PUNCT
admet-686	212	40	hcl	hcl	PROPN
admet-686	212	41	,	,	PUNCT
admet-686	212	42	phosphate	phosphate	ADJ
admet-686	212	43	,	,	PUNCT
admet-686	212	44	maleate	maleate	NOUN
admet-686	212	45	)	)	PUNCT
admet-686	212	46	is	be	AUX
admet-686	212	47	only	only	ADV
admet-686	212	48	about	about	ADV
admet-686	212	49	1	1	NUM
admet-686	212	50	-	-	SYM
admet-686	212	51	5	5	NUM
admet-686	212	52	mg	mg	NUM
admet-686	212	53	/	/	SYM
admet-686	212	54	ml	ml	NOUN
admet-686	212	55	.	.	NOUN
admet-686	212	56	similar	similar	ADJ
admet-686	212	57	solubility	solubility	NOUN
admet-686	212	58	enhancements	enhancement	NOUN
admet-686	212	59	were	be	AUX
admet-686	212	60	observed	observe	VERB
admet-686	212	61	with	with	ADP
admet-686	212	62	itraconazole	itraconazole	NOUN
admet-686	212	63	by	by	ADP
admet-686	212	64	the	the	DET
admet-686	212	65	investigators	investigator	NOUN
admet-686	212	66	.	.	PUNCT
admet-686	213	1	the	the	DET
admet-686	213	2	extraordinary	extraordinary	ADJ
admet-686	213	3	enhancement	enhancement	NOUN
admet-686	213	4	by	by	ADP
admet-686	213	5	acid	acid	NOUN
admet-686	213	6	-	-	PUNCT
admet-686	213	7	base	base	NOUN
admet-686	213	8	interaction	interaction	NOUN
admet-686	213	9	has	have	AUX
admet-686	213	10	been	be	AUX
admet-686	213	11	called	call	VERB
admet-686	213	12	‘	'	PUNCT
admet-686	213	13	supersolubilization	supersolubilization	NOUN
admet-686	213	14	.	.	PUNCT
admet-686	213	15	’	'	PUNCT
admet-686	214	1	on	on	ADP
admet-686	214	2	drying	dry	VERB
admet-686	214	3	,	,	PUNCT
admet-686	214	4	the	the	DET
admet-686	214	5	drug	drug	NOUN
admet-686	214	6	-	-	PUNCT
admet-686	214	7	containing	contain	VERB
admet-686	214	8	material	material	NOUN
admet-686	214	9	is	be	AUX
admet-686	214	10	a	a	DET
admet-686	214	11	semisolid	semisolid	NOUN
admet-686	214	12	and	and	CCONJ
admet-686	214	13	sticky	sticky	ADJ
admet-686	214	14	amorphous	amorphous	ADJ
admet-686	214	15	solid	solid	ADJ
admet-686	214	16	dispersion	dispersion	NOUN
admet-686	214	17	.	.	PUNCT
admet-686	215	1	free	free	ADJ
admet-686	215	2	-	-	PUNCT
admet-686	215	3	flowing	flow	VERB
admet-686	215	4	powders	powder	NOUN
admet-686	215	5	that	that	PRON
admet-686	215	6	can	can	AUX
admet-686	215	7	be	be	AUX
admet-686	215	8	compressed	compress	VERB
admet-686	215	9	into	into	ADP
admet-686	215	10	tablets	tablet	NOUN
admet-686	215	11	are	be	AUX
admet-686	215	12	obtained	obtain	VERB
admet-686	215	13	by	by	ADP
admet-686	215	14	e.g.	e.g.	ADV
admet-686	215	15	,	,	PUNCT
admet-686	215	16	adsorbing	adsorb	VERB
admet-686	215	17	drug	drug	NOUN
admet-686	215	18	solid	solid	ADJ
admet-686	215	19	dispersions	dispersion	NOUN
admet-686	215	20	with	with	ADP
admet-686	215	21	acids	acid	NOUN
admet-686	215	22	onto	onto	ADP
admet-686	215	23	porous	porous	ADJ
admet-686	215	24	silica	silica	NOUN
admet-686	215	25	[	[	X
admet-686	215	26	44	44	NUM
admet-686	215	27	]	]	PUNCT
admet-686	215	28	.	.	PUNCT
admet-686	216	1	cocrystals	cocrystal	NOUN
admet-686	216	2	enhancement	enhancement	NOUN
admet-686	216	3	of	of	ADP
admet-686	216	4	solubility	solubility	NOUN
admet-686	216	5	xanthines	xanthine	NOUN
admet-686	216	6	(	(	PUNCT
admet-686	216	7	e.g.	e.g.	ADV
admet-686	216	8	,	,	PUNCT
admet-686	216	9	caffeine	caffeine	NOUN
admet-686	216	10	,	,	PUNCT
admet-686	216	11	theophylline	theophylline	NOUN
admet-686	216	12	,	,	PUNCT
admet-686	216	13	theobromine	theobromine	NOUN
admet-686	216	14	)	)	PUNCT
admet-686	216	15	are	be	AUX
admet-686	216	16	known	know	VERB
admet-686	216	17	to	to	PART
admet-686	216	18	form	form	VERB
admet-686	216	19	complexes	complex	NOUN
admet-686	216	20	with	with	ADP
admet-686	216	21	many	many	ADJ
admet-686	216	22	pharmaceutical	pharmaceutical	ADJ
admet-686	216	23	compounds	compound	NOUN
admet-686	216	24	.	.	PUNCT
admet-686	217	1	in	in	ADP
admet-686	217	2	a	a	DET
admet-686	217	3	series	series	NOUN
admet-686	217	4	of	of	ADP
admet-686	217	5	papers	paper	NOUN
admet-686	217	6	(	(	PUNCT
admet-686	217	7	1952	1952	NUM
admet-686	217	8	-	-	SYM
admet-686	217	9	1954	1954	NUM
admet-686	217	10	)	)	PUNCT
admet-686	217	11	higuchi	higuchi	PROPN
admet-686	217	12	,	,	PUNCT
admet-686	217	13	zuck	zuck	PROPN
admet-686	217	14	and	and	CCONJ
admet-686	217	15	lach	lach	PROPN
admet-686	218	1	[	[	X
admet-686	218	2	45	45	NUM
admet-686	218	3	]	]	PUNCT
admet-686	218	4	studied	study	VERB
admet-686	218	5	the	the	DET
admet-686	218	6	xanthine	xanthine	NOUN
admet-686	218	7	molecular	molecular	PROPN
admet-686	218	8	associations	association	NOUN
admet-686	218	9	formed	form	VERB
admet-686	218	10	with	with	ADP
admet-686	218	11	simple	simple	ADJ
admet-686	218	12	organic	organic	ADJ
admet-686	218	13	molecules	molecule	NOUN
admet-686	218	14	in	in	ADP
admet-686	218	15	saturated	saturated	ADJ
admet-686	218	16	solutions	solution	NOUN
admet-686	218	17	.	.	PUNCT
admet-686	219	1	weak	weak	ADJ
admet-686	219	2	caffeine	caffeine	NOUN
admet-686	219	3	-	-	PUNCT
admet-686	219	4	containing	contain	VERB
admet-686	219	5	complexes	complex	NOUN
admet-686	219	6	were	be	AUX
admet-686	219	7	determined	determine	VERB
admet-686	219	8	to	to	PART
admet-686	219	9	form	form	VERB
admet-686	219	10	,	,	PUNCT
admet-686	219	11	in	in	ADP
admet-686	219	12	the	the	DET
admet-686	219	13	decreasing	decrease	VERB
admet-686	219	14	order	order	NOUN
admet-686	219	15	of	of	ADP
admet-686	219	16	stability	stability	NOUN
admet-686	219	17	:	:	PUNCT
admet-686	219	18	phydroxybenzoic	phydroxybenzoic	ADJ
admet-686	219	19	acid	acid	PROPN
admet-686	219	20	>	>	X
admet-686	219	21	benzocaine	benzocaine	NOUN
admet-686	219	22	>	>	X
admet-686	219	23	butylparaben	butylparaben	PROPN
admet-686	219	24	>	>	X
admet-686	219	25	p	p	ADJ
admet-686	219	26	-	-	PUNCT
admet-686	219	27	aminobenzoic	aminobenzoic	ADJ
admet-686	219	28	acid	acid	NOUN
admet-686	219	29	>	>	X
admet-686	219	30	salicylic	salicylic	PROPN
admet-686	219	31	acid	acid	PROPN
admet-686	219	32	>	>	X
admet-686	219	33	benzoic	benzoic	PROPN
admet-686	219	34	acid	acid	PROPN
admet-686	219	35	>	>	X
admet-686	219	36	aspirin	aspirin	NOUN
admet-686	219	37	>	>	X
admet-686	220	1	o	o	ADJ
admet-686	220	2	-	-	ADJ
admet-686	220	3	phthalic	phthalic	ADJ
admet-686	220	4	acid	acid	NOUN
admet-686	220	5	>	>	X
admet-686	220	6	benzoate	benzoate	NOUN
admet-686	220	7	>	>	X
admet-686	220	8	sulfathiazole	sulfathiazole	PROPN
admet-686	220	9	>	>	X
admet-686	220	10	picric	picric	PROPN
admet-686	220	11	acid	acid	PROPN
admet-686	220	12	>	>	X
admet-686	220	13	sulfadiazine	sulfadiazine	PROPN
admet-686	220	14	>	>	X
admet-686	220	15	suberic	suberic	ADJ
admet-686	220	16	acid	acid	PROPN
admet-686	220	17	.	.	PUNCT
admet-686	221	1	such	such	ADJ
admet-686	221	2	complexes	complex	NOUN
admet-686	221	3	raised	raise	VERB
admet-686	221	4	the	the	DET
admet-686	221	5	solubility	solubility	NOUN
admet-686	221	6	of	of	ADP
admet-686	221	7	the	the	DET
admet-686	221	8	xanthine	xanthine	NOUN
admet-686	221	9	.	.	PUNCT
admet-686	222	1	these	these	DET
admet-686	222	2	classic	classic	ADJ
admet-686	222	3	studies	study	NOUN
admet-686	222	4	may	may	AUX
admet-686	222	5	bear	bear	VERB
admet-686	222	6	relevance	relevance	NOUN
admet-686	222	7	to	to	ADP
admet-686	222	8	the	the	DET
admet-686	222	9	selection	selection	NOUN
admet-686	222	10	of	of	ADP
admet-686	222	11	‘	'	PUNCT
admet-686	222	12	coformers	coformer	NOUN
admet-686	222	13	’	'	PUNCT
admet-686	222	14	in	in	ADP
admet-686	222	15	cocrystal	cocrystal	ADJ
admet-686	222	16	formation	formation	NOUN
admet-686	222	17	.	.	PUNCT
admet-686	223	1	a	a	DET
admet-686	223	2	recent	recent	ADJ
admet-686	223	3	and	and	CCONJ
admet-686	223	4	still	still	ADV
admet-686	223	5	evolving	evolve	VERB
admet-686	223	6	formulation	formulation	NOUN
admet-686	223	7	strategy	strategy	NOUN
admet-686	223	8	to	to	PART
admet-686	223	9	increase	increase	VERB
admet-686	223	10	intestinal	intestinal	ADJ
admet-686	223	11	absorption	absorption	NOUN
admet-686	223	12	is	be	AUX
admet-686	223	13	based	base	VERB
admet-686	223	14	on	on	ADP
admet-686	223	15	using	use	VERB
admet-686	223	16	cocrystals	cocrystal	NOUN
admet-686	223	17	[	[	X
admet-686	223	18	46	46	NUM
admet-686	223	19	]	]	PUNCT
admet-686	223	20	.	.	PUNCT
admet-686	224	1	cocrystals	cocrystal	NOUN
admet-686	224	2	are	be	AUX
admet-686	224	3	materials	material	NOUN
admet-686	224	4	composed	compose	VERB
admet-686	224	5	of	of	ADP
admet-686	224	6	two	two	NUM
admet-686	224	7	or	or	CCONJ
admet-686	224	8	more	more	ADV
admet-686	224	9	different	different	ADJ
admet-686	224	10	uncharged	uncharged	ADJ
admet-686	224	11	molecules	molecule	NOUN
admet-686	224	12	(	(	PUNCT
admet-686	224	13	e.g.	e.g.	ADV
admet-686	224	14	,	,	PUNCT
admet-686	224	15	drug	drug	NOUN
admet-686	224	16	and	and	CCONJ
admet-686	224	17	‘	'	PUNCT
admet-686	224	18	coformer	coformer	NOUN
admet-686	224	19	’	'	PUNCT
admet-686	224	20	)	)	PUNCT
admet-686	224	21	within	within	ADP
admet-686	224	22	the	the	DET
admet-686	224	23	same	same	ADJ
admet-686	224	24	crystal	crystal	NOUN
admet-686	224	25	lattice	lattice	NOUN
admet-686	224	26	,	,	PUNCT
admet-686	224	27	which	which	PRON
admet-686	224	28	are	be	AUX
admet-686	224	29	associated	associate	VERB
admet-686	224	30	by	by	ADP
admet-686	224	31	nonionic	nonionic	ADJ
admet-686	224	32	and	and	CCONJ
admet-686	224	33	noncovalent	noncovalent	NOUN
admet-686	224	34	bonds	bond	NOUN
admet-686	224	35	.	.	PUNCT
admet-686	225	1	the	the	DET
admet-686	225	2	altered	alter	VERB
admet-686	225	3	solid	solid	ADJ
admet-686	225	4	state	state	NOUN
admet-686	225	5	properties	property	NOUN
admet-686	225	6	in	in	ADP
admet-686	225	7	cocrystals	cocrystal	NOUN
admet-686	225	8	are	be	AUX
admet-686	225	9	generally	generally	ADV
admet-686	225	10	expected	expect	VERB
admet-686	225	11	to	to	PART
admet-686	225	12	elevate	elevate	VERB
admet-686	225	13	the	the	DET
admet-686	225	14	drug	drug	NOUN
admet-686	225	15	concentration	concentration	NOUN
admet-686	225	16	in	in	ADP
admet-686	225	17	a	a	DET
admet-686	225	18	similar	similar	ADJ
admet-686	225	19	way	way	NOUN
admet-686	225	20	that	that	PRON
admet-686	225	21	drug	drug	NOUN
admet-686	225	22	salts	salt	NOUN
admet-686	225	23	do	do	VERB
admet-686	225	24	,	,	PUNCT
admet-686	225	25	as	as	SCONJ
admet-686	225	26	the	the	DET
admet-686	225	27	drug	drug	NOUN
admet-686	225	28	is	be	AUX
admet-686	225	29	released	release	VERB
admet-686	225	30	in	in	ADP
admet-686	225	31	a	a	DET
admet-686	225	32	dissolution	dissolution	NOUN
admet-686	225	33	process	process	NOUN
admet-686	225	34	.	.	PUNCT
admet-686	226	1	the	the	DET
admet-686	226	2	initially	initially	ADV
admet-686	226	3	elevated	elevated	ADJ
admet-686	226	4	concentration	concentration	NOUN
admet-686	226	5	of	of	ADP
admet-686	226	6	the	the	DET
admet-686	226	7	drug	drug	NOUN
admet-686	226	8	could	could	AUX
admet-686	226	9	lead	lead	VERB
admet-686	226	10	to	to	ADP
admet-686	226	11	increased	increase	VERB
admet-686	226	12	oral	oral	ADJ
admet-686	226	13	absorption	absorption	NOUN
admet-686	226	14	of	of	ADP
admet-686	226	15	the	the	DET
admet-686	226	16	drug	drug	NOUN
admet-686	226	17	.	.	PUNCT
admet-686	227	1	the	the	DET
admet-686	227	2	analyses	analysis	NOUN
admet-686	227	3	of	of	ADP
admet-686	227	4	solubility	solubility	NOUN
admet-686	227	5	of	of	ADP
admet-686	227	6	salts	salt	NOUN
admet-686	227	7	and	and	CCONJ
admet-686	227	8	cocrystals	cocrystal	NOUN
admet-686	227	9	are	be	AUX
admet-686	227	10	similar	similar	ADJ
admet-686	227	11	,	,	PUNCT
admet-686	227	12	since	since	SCONJ
admet-686	227	13	both	both	PRON
admet-686	227	14	are	be	AUX
admet-686	227	15	multi	multi	ADJ
admet-686	227	16	-	-	ADJ
admet-686	227	17	component	component	ADJ
admet-686	227	18	solids	solid	NOUN
admet-686	227	19	.	.	PUNCT
admet-686	228	1	drug	drug	NOUN
admet-686	228	2	salts	salt	NOUN
admet-686	228	3	are	be	AUX
admet-686	228	4	characterized	characterize	VERB
admet-686	228	5	by	by	ADP
admet-686	228	6	a	a	DET
admet-686	228	7	solubility	solubility	NOUN
admet-686	228	8	product	product	NOUN
admet-686	228	9	,	,	PUNCT
admet-686	228	10	ksp	ksp	PROPN
admet-686	228	11	salt=	salt=	PROPN
admet-686	229	1	[	[	X
admet-686	229	2	drug][counterion	drug][counterion	NOUN
admet-686	229	3	]	]	PUNCT
admet-686	229	4	,	,	PUNCT
admet-686	229	5	where	where	SCONJ
admet-686	229	6	the	the	DET
admet-686	229	7	drug	drug	NOUN
admet-686	229	8	is	be	AUX
admet-686	229	9	charged	charge	VERB
admet-686	229	10	.	.	PUNCT
admet-686	230	1	cocrystals	cocrystal	NOUN
admet-686	230	2	are	be	AUX
admet-686	230	3	similarly	similarly	ADV
admet-686	230	4	characterized	characterize	VERB
admet-686	230	5	by	by	ADP
admet-686	230	6	an	an	DET
admet-686	230	7	equilibrium	equilibrium	NOUN
admet-686	230	8	solubility	solubility	NOUN
admet-686	230	9	product	product	NOUN
admet-686	230	10	,	,	PUNCT
admet-686	230	11	ksp	ksp	PROPN
admet-686	230	12	cc	cc	PROPN
admet-686	231	1	=	=	PUNCT
admet-686	232	1	[	[	X
admet-686	232	2	drug][coformer	drug][coformer	NOUN
admet-686	232	3	]	]	X
admet-686	232	4	,	,	PUNCT
admet-686	232	5	but	but	CCONJ
admet-686	232	6	in	in	ADP
admet-686	232	7	contrast	contrast	NOUN
admet-686	232	8	to	to	ADP
admet-686	232	9	salts	salt	NOUN
admet-686	232	10	,	,	PUNCT
admet-686	232	11	both	both	CCONJ
admet-686	232	12	the	the	DET
admet-686	232	13	drug	drug	NOUN
admet-686	232	14	and	and	CCONJ
admet-686	232	15	the	the	DET
admet-686	232	16	coformer	coformer	NOUN
admet-686	232	17	are	be	AUX
admet-686	232	18	uncharged	uncharged	ADJ
admet-686	232	19	in	in	ADP
admet-686	232	20	the	the	DET
admet-686	232	21	cocrystal	cocrystal	NOUN
admet-686	232	22	.	.	PUNCT
admet-686	233	1	a	a	DET
admet-686	233	2	method	method	NOUN
admet-686	233	3	to	to	PART
admet-686	233	4	predict	predict	VERB
admet-686	233	5	ksp	ksp	PROPN
admet-686	233	6	cc	cc	PROPN
admet-686	233	7	and	and	CCONJ
admet-686	233	8	the	the	DET
admet-686	233	9	solubility	solubility	NOUN
admet-686	233	10	enhancement	enhancement	NOUN
admet-686	233	11	of	of	ADP
admet-686	233	12	cocrystals	cocrystal	NOUN
admet-686	233	13	,	,	PUNCT
admet-686	233	14	using	use	VERB
admet-686	233	15	an	an	DET
admet-686	233	16	approach	approach	NOUN
admet-686	233	17	based	base	VERB
admet-686	233	18	on	on	ADP
admet-686	233	19	measured	measured	ADJ
admet-686	233	20	drug	drug	NOUN
admet-686	233	21	and	and	CCONJ
admet-686	233	22	coformer	coformer	NOUN
admet-686	233	23	intrinsic	intrinsic	ADJ
admet-686	233	24	solubility	solubility	NOUN
admet-686	233	25	(	(	PUNCT
admet-686	233	26	s0	s0	NOUN
admet-686	233	27	drug	drug	NOUN
admet-686	233	28	,	,	PUNCT
admet-686	233	29	s0	s0	PROPN
admet-686	233	30	cof	cof	PROPN
admet-686	233	31	)	)	PUNCT
admet-686	233	32	,	,	PUNCT
admet-686	233	33	combined	combine	VERB
admet-686	233	34	with	with	ADP
admet-686	233	35	in	in	ADP
admet-686	233	36	silico	silico	NOUN
admet-686	233	37	h	h	NOUN
admet-686	233	38	-	-	PUNCT
admet-686	233	39	bond	bond	NOUN
admet-686	233	40	descriptors	descriptor	NOUN
admet-686	233	41	,	,	PUNCT
admet-686	233	42	has	have	AUX
admet-686	233	43	been	be	AUX
admet-686	233	44	recently	recently	ADV
admet-686	233	45	described	describe	VERB
admet-686	233	46	[	[	PUNCT
admet-686	233	47	47,48	47,48	NUM
admet-686	233	48	]	]	X
admet-686	233	49	.	.	PUNCT
admet-686	234	1	the	the	DET
admet-686	234	2	latter	latter	ADJ
admet-686	234	3	publications	publication	NOUN
admet-686	234	4	arose	arise	VERB
admet-686	234	5	out	out	ADP
admet-686	234	6	of	of	ADP
admet-686	234	7	the	the	DET
admet-686	234	8	iapc-6	iapc-6	NUM
admet-686	234	9	special	special	ADJ
admet-686	234	10	session	session	NOUN
admet-686	234	11	on	on	ADP
admet-686	234	12	cocrystal	cocrystal	ADJ
admet-686	234	13	solubility	solubility	PROPN
admet-686	234	14	.	.	PUNCT
admet-686	235	1	figure	figure	NOUN
admet-686	235	2	8	8	NUM
admet-686	235	3	shows	show	VERB
admet-686	235	4	an	an	DET
admet-686	235	5	example	example	NOUN
admet-686	235	6	of	of	ADP
admet-686	235	7	a	a	DET
admet-686	235	8	solubility	solubility	NOUN
admet-686	235	9	profile	profile	NOUN
admet-686	235	10	as	as	ADP
admet-686	235	11	a	a	DET
admet-686	235	12	function	function	NOUN
admet-686	235	13	of	of	ADP
admet-686	235	14	ph	ph	NOUN
admet-686	235	15	for	for	ADP
admet-686	235	16	the	the	DET
admet-686	235	17	indomethacin	indomethacin	NOUN
admet-686	235	18	:	:	PUNCT
admet-686	235	19	saccharin	saccharin	NOUN
admet-686	235	20	cocrystal	cocrystal	NOUN
admet-686	236	1	[	[	X
admet-686	236	2	49	49	NUM
admet-686	236	3	]	]	PUNCT
admet-686	236	4	.	.	PUNCT
admet-686	237	1	the	the	DET
admet-686	237	2	points	point	NOUN
admet-686	237	3	represent	represent	VERB
admet-686	237	4	the	the	DET
admet-686	237	5	measured	measured	ADJ
admet-686	237	6	total	total	ADJ
admet-686	237	7	concentrations	concentration	NOUN
admet-686	237	8	of	of	ADP
admet-686	237	9	the	the	DET
admet-686	237	10	coformer	coformer	NOUN
admet-686	237	11	saccharin	saccharin	NOUN
admet-686	237	12	(	(	PUNCT
admet-686	237	13	blue	blue	ADJ
admet-686	237	14	squares	square	NOUN
admet-686	237	15	)	)	PUNCT
admet-686	237	16	and	and	CCONJ
admet-686	237	17	the	the	DET
admet-686	237	18	drug	drug	NOUN
admet-686	237	19	indomethacin	indomethacin	NOUN
admet-686	237	20	(	(	PUNCT
admet-686	237	21	red	red	ADJ
admet-686	237	22	circles	circle	NOUN
admet-686	237	23	)	)	PUNCT
admet-686	237	24	under	under	ADP
admet-686	237	25	equilibrium	equilibrium	NOUN
admet-686	237	26	conditions	condition	NOUN
admet-686	237	27	poised	poise	VERB
admet-686	237	28	at	at	ADP
admet-686	237	29	72	72	NUM
admet-686	237	30	-	-	SYM
admet-686	237	31	96	96	NUM
admet-686	237	32	h	h	NOUN
admet-686	237	33	,	,	PUNCT
admet-686	237	34	where	where	SCONJ
admet-686	237	35	both	both	CCONJ
admet-686	237	36	the	the	DET
admet-686	237	37	cocrystal	cocrystal	NOUN
admet-686	237	38	and	and	CCONJ
admet-686	237	39	the	the	DET
admet-686	237	40	free	free	ADJ
admet-686	237	41	-	-	PUNCT
admet-686	237	42	acid	acid	ADJ
admet-686	237	43	crystalline	crystalline	NOUN
admet-686	237	44	drug	drug	NOUN
admet-686	237	45	are	be	AUX
admet-686	237	46	indefinitely	indefinitely	ADV
admet-686	237	47	stable	stable	ADJ
admet-686	237	48	co	co	NOUN
admet-686	237	49	-	-	NOUN
admet-686	237	50	precipitates	precipitate	NOUN
admet-686	237	51	below	below	ADP
admet-686	237	52	ph	ph	NOUN
admet-686	237	53	3.7	3.7	NUM
admet-686	237	54	.	.	PUNCT
admet-686	238	1	as	as	SCONJ
admet-686	238	2	the	the	DET
admet-686	238	3	cocrystal	cocrystal	NOUN
admet-686	238	4	partially	partially	ADV
admet-686	238	5	dissolves	dissolve	VERB
admet-686	238	6	below	below	ADP
admet-686	238	7	ph	ph	X
admet-686	238	8	3.7	3.7	NUM
admet-686	238	9	,	,	PUNCT
admet-686	238	10	it	it	PRON
admet-686	238	11	releases	release	VERB
admet-686	238	12	the	the	DET
admet-686	238	13	solvated	solvate	VERB
admet-686	238	14	free	free	ADJ
admet-686	238	15	drug	drug	NOUN
admet-686	238	16	at	at	ADP
admet-686	238	17	the	the	DET
admet-686	238	18	concentration	concentration	NOUN
admet-686	238	19	indicated	indicate	VERB
admet-686	238	20	by	by	ADP
admet-686	238	21	the	the	DET
admet-686	238	22	scc	scc	PROPN
admet-686	238	23	thick	thick	PROPN
admet-686	238	24	dashed	dash	VERB
admet-686	238	25	line	line	NOUN
admet-686	238	26	.	.	PUNCT
admet-686	239	1	this	this	PRON
admet-686	239	2	is	be	AUX
admet-686	239	3	the	the	DET
admet-686	239	4	initial	initial	ADJ
admet-686	239	5	supersaturated	supersaturated	ADJ
admet-686	239	6	concentration	concentration	NOUN
admet-686	239	7	of	of	ADP
admet-686	239	8	the	the	DET
admet-686	239	9	drug	drug	NOUN
admet-686	239	10	.	.	PUNCT
admet-686	240	1	it	it	PRON
admet-686	240	2	may	may	AUX
admet-686	240	3	not	not	PART
admet-686	240	4	persist	persist	VERB
admet-686	240	5	long	long	ADV
admet-686	240	6	,	,	PUNCT
admet-686	240	7	but	but	CCONJ
admet-686	240	8	while	while	SCONJ
admet-686	240	9	the	the	DET
admet-686	240	10	drug	drug	NOUN
admet-686	240	11	is	be	AUX
admet-686	240	12	in	in	ADP
admet-686	240	13	the	the	DET
admet-686	240	14	elevated	elevated	ADJ
admet-686	240	15	concentration	concentration	NOUN
admet-686	240	16	,	,	PUNCT
admet-686	240	17	its	its	PRON
admet-686	240	18	intestinal	intestinal	ADJ
admet-686	240	19	absorption	absorption	NOUN
admet-686	240	20	may	may	AUX
admet-686	240	21	be	be	AUX
admet-686	240	22	significantly	significantly	ADV
admet-686	240	23	enhanced	enhance	VERB
admet-686	240	24	.	.	PUNCT
admet-686	241	1	the	the	DET
admet-686	241	2	henderson	henderson	PROPN
admet-686	241	3	-	-	PUNCT
admet-686	241	4	hasselbalch	hasselbalch	PROPN
admet-686	241	5	curve	curve	NOUN
admet-686	241	6	for	for	ADP
admet-686	241	7	indomethacin	indomethacin	NOUN
admet-686	241	8	is	be	AUX
admet-686	241	9	indicated	indicate	VERB
admet-686	241	10	by	by	ADP
admet-686	241	11	the	the	DET
admet-686	241	12	dashed	dash	VERB
admet-686	241	13	red	red	ADJ
admet-686	241	14	curve	curve	NOUN
admet-686	241	15	in	in	ADP
admet-686	241	16	the	the	DET
admet-686	241	17	bottom	bottom	NOUN
admet-686	241	18	of	of	ADP
admet-686	241	19	the	the	DET
admet-686	241	20	drawing	drawing	NOUN
admet-686	241	21	.	.	PUNCT
admet-686	242	1	the	the	DET
admet-686	242	2	equilibrium	equilibrium	NOUN
admet-686	242	3	concentration	concentration	NOUN
admet-686	242	4	of	of	ADP
admet-686	242	5	indomethacin	indomethacin	NOUN
admet-686	242	6	(	(	PUNCT
admet-686	242	7	solid	solid	ADJ
admet-686	242	8	red	red	ADJ
admet-686	242	9	curve	curve	NOUN
admet-686	242	10	)	)	PUNCT
admet-686	242	11	is	be	AUX
admet-686	242	12	bergström	bergström	NOUN
admet-686	242	13	and	and	CCONJ
admet-686	242	14	avdeef	avdeef	PROPN
admet-686	242	15	admet	admet	PROPN
admet-686	242	16	&	&	CCONJ
admet-686	242	17	dmpk	dmpk	PROPN
admet-686	242	18	7(2	7(2	NUM
admet-686	242	19	)	)	PUNCT
admet-686	242	20	(	(	PUNCT
admet-686	242	21	2019	2019	NUM
admet-686	242	22	)	)	PUNCT
admet-686	242	23	88	88	NUM
admet-686	242	24	-	-	SYM
admet-686	242	25	105	105	NUM
admet-686	242	26	98	98	NUM
admet-686	242	27	above	above	ADP
admet-686	242	28	the	the	DET
admet-686	242	29	dashed	dash	VERB
admet-686	242	30	curve	curve	NOUN
admet-686	242	31	,	,	PUNCT
admet-686	242	32	with	with	ADP
admet-686	242	33	the	the	DET
admet-686	242	34	difference	difference	NOUN
admet-686	242	35	peaking	peak	VERB
admet-686	242	36	at	at	ADP
admet-686	242	37	about	about	ADP
admet-686	242	38	ph	ph	NOUN
admet-686	242	39	3.7	3.7	NUM
admet-686	242	40	.	.	PUNCT
admet-686	243	1	this	this	PRON
admet-686	243	2	can	can	AUX
admet-686	243	3	be	be	AUX
admet-686	243	4	explained	explain	VERB
admet-686	243	5	by	by	ADP
admet-686	243	6	the	the	DET
admet-686	243	7	complexation	complexation	NOUN
admet-686	243	8	of	of	ADP
admet-686	243	9	uncharged	uncharged	ADJ
admet-686	243	10	drug	drug	NOUN
admet-686	243	11	by	by	ADP
admet-686	243	12	the	the	DET
admet-686	243	13	anionic	anionic	ADJ
admet-686	243	14	saccharin	saccharin	NOUN
admet-686	243	15	.	.	PUNCT
admet-686	244	1	the	the	DET
admet-686	244	2	effect	effect	NOUN
admet-686	244	3	diminishes	diminish	VERB
admet-686	244	4	above	above	ADP
admet-686	244	5	ph	ph	NOUN
admet-686	244	6	5	5	NUM
admet-686	244	7	,	,	PUNCT
admet-686	244	8	since	since	SCONJ
admet-686	244	9	the	the	DET
admet-686	244	10	concentration	concentration	NOUN
admet-686	244	11	of	of	ADP
admet-686	244	12	the	the	DET
admet-686	244	13	free	free	ADJ
admet-686	244	14	drug	drug	NOUN
admet-686	244	15	diminishes	diminish	VERB
admet-686	244	16	due	due	ADJ
admet-686	244	17	to	to	ADP
admet-686	244	18	ionization	ionization	NOUN
admet-686	244	19	[	[	X
admet-686	244	20	47	47	NUM
admet-686	244	21	]	]	PUNCT
admet-686	244	22	.	.	PUNCT
admet-686	245	1	figure	figure	NOUN
admet-686	245	2	8	8	NUM
admet-686	245	3	.	.	PUNCT
admet-686	246	1	plot	plot	NOUN
admet-686	246	2	of	of	ADP
admet-686	246	3	the	the	DET
admet-686	246	4	total	total	ADJ
admet-686	246	5	equilibrium	equilibrium	NOUN
admet-686	246	6	concentrations	concentration	NOUN
admet-686	246	7	of	of	ADP
admet-686	246	8	saccharin	saccharin	NOUN
admet-686	246	9	(	(	PUNCT
admet-686	246	10	upper	upper	ADJ
admet-686	246	11	solid	solid	ADJ
admet-686	246	12	line	line	NOUN
admet-686	246	13	,	,	PUNCT
admet-686	246	14	blue	blue	NOUN
admet-686	246	15	)	)	PUNCT
admet-686	246	16	,	,	PUNCT
admet-686	246	17	indomethacin	indomethacin	X
admet-686	246	18	(	(	PUNCT
admet-686	246	19	lower	low	ADJ
admet-686	246	20	solid	solid	ADJ
admet-686	246	21	line	line	NOUN
admet-686	246	22	,	,	PUNCT
admet-686	246	23	red	red	NOUN
admet-686	246	24	)	)	PUNCT
admet-686	246	25	,	,	PUNCT
admet-686	246	26	and	and	CCONJ
admet-686	246	27	of	of	ADP
admet-686	246	28	the	the	DET
admet-686	246	29	maximum	maximum	ADJ
admet-686	246	30	possible	possible	ADJ
admet-686	246	31	concentration	concentration	NOUN
admet-686	246	32	of	of	ADP
admet-686	246	33	the	the	DET
admet-686	246	34	solubilized	solubilize	VERB
admet-686	246	35	indomethacin	indomethacin	NOUN
admet-686	246	36	released	release	VERB
admet-686	246	37	from	from	ADP
admet-686	246	38	the	the	DET
admet-686	246	39	cocrystal	cocrystal	ADJ
admet-686	246	40	(	(	PUNCT
admet-686	246	41	thick	thick	ADJ
admet-686	246	42	dashed	dash	VERB
admet-686	246	43	curve	curve	NOUN
admet-686	246	44	,	,	PUNCT
admet-686	246	45	scc	scc	PROPN
admet-686	246	46	)	)	PUNCT
admet-686	246	47	,	,	PUNCT
admet-686	246	48	as	as	ADP
admet-686	246	49	a	a	DET
admet-686	246	50	function	function	NOUN
admet-686	246	51	of	of	ADP
admet-686	246	52	ph	ph	PROPN
admet-686	246	53	.	.	PROPN
admet-686	246	54	scc	scc	PROPN
admet-686	246	55	is	be	AUX
admet-686	246	56	termed	term	VERB
admet-686	246	57	the	the	DET
admet-686	246	58	‘	'	PUNCT
admet-686	246	59	cocrystal	cocrystal	ADJ
admet-686	246	60	solubility	solubility	NOUN
admet-686	246	61	.	.	PUNCT
admet-686	246	62	’	'	PUNCT
admet-686	247	1	the	the	DET
admet-686	247	2	elevation	elevation	NOUN
admet-686	247	3	of	of	ADP
admet-686	247	4	the	the	DET
admet-686	247	5	scc	scc	PROPN
admet-686	247	6	dashed	dash	VERB
admet-686	247	7	curve	curve	NOUN
admet-686	247	8	above	above	ADP
admet-686	247	9	that	that	PRON
admet-686	247	10	of	of	ADP
admet-686	247	11	the	the	DET
admet-686	247	12	indomethacin	indomethacin	PROPN
admet-686	247	13	equilibrium	equilibrium	NOUN
admet-686	247	14	solid	solid	ADJ
admet-686	247	15	red	red	ADJ
admet-686	247	16	curve	curve	NOUN
admet-686	247	17	is	be	AUX
admet-686	247	18	viewed	view	VERB
admet-686	247	19	as	as	ADP
admet-686	247	20	the	the	DET
admet-686	247	21	cocrystal	cocrystal	ADJ
admet-686	247	22	‘	'	PUNCT
admet-686	247	23	solubility	solubility	NOUN
admet-686	247	24	advantage	advantage	NOUN
admet-686	247	25	.	.	PUNCT
admet-686	247	26	’	'	PUNCT
admet-686	248	1	the	the	DET
admet-686	248	2	solubility	solubility	NOUN
admet-686	248	3	product	product	NOUN
admet-686	248	4	is	be	AUX
admet-686	248	5	no	no	ADV
admet-686	248	6	longer	long	ADV
admet-686	248	7	satisfied	satisfied	ADJ
admet-686	248	8	above	above	ADP
admet-686	248	9	ph	ph	NOUN
admet-686	248	10	3.7	3.7	NUM
admet-686	248	11	,	,	PUNCT
admet-686	248	12	so	so	ADV
admet-686	248	13	the	the	DET
admet-686	248	14	cocrystal	cocrystal	ADJ
admet-686	248	15	no	no	ADV
admet-686	248	16	longer	long	ADV
admet-686	248	17	forms	form	NOUN
admet-686	248	18	above	above	ADP
admet-686	248	19	that	that	DET
admet-686	248	20	ph	ph	PROPN
admet-686	248	21	.	.	PROPN
admet-686	248	22	data	datum	NOUN
admet-686	248	23	quality	quality	NOUN
admet-686	248	24	a	a	DET
admet-686	248	25	comprehensive	comprehensive	ADJ
admet-686	248	26	study	study	NOUN
admet-686	248	27	of	of	ADP
admet-686	248	28	equilibrium	equilibrium	NOUN
admet-686	248	29	solubility	solubility	NOUN
admet-686	248	30	data	datum	NOUN
admet-686	248	31	quality	quality	NOUN
admet-686	248	32	based	base	VERB
admet-686	248	33	on	on	ADP
admet-686	248	34	the	the	DET
admet-686	248	35	review	review	NOUN
admet-686	248	36	of	of	ADP
admet-686	248	37	over	over	ADP
admet-686	248	38	800	800	NUM
admet-686	248	39	publications	publication	NOUN
admet-686	248	40	was	be	AUX
admet-686	248	41	reported	report	VERB
admet-686	248	42	in	in	ADP
admet-686	248	43	2015	2015	NUM
admet-686	248	44	[	[	X
admet-686	248	45	50	50	NUM
admet-686	248	46	]	]	PUNCT
admet-686	248	47	.	.	PUNCT
admet-686	249	1	since	since	SCONJ
admet-686	249	2	then	then	ADV
admet-686	249	3	,	,	PUNCT
admet-686	249	4	more	more	ADJ
admet-686	249	5	studies	study	NOUN
admet-686	249	6	have	have	AUX
admet-686	249	7	been	be	AUX
admet-686	249	8	examined	examine	VERB
admet-686	249	9	and	and	CCONJ
admet-686	249	10	a	a	DET
admet-686	249	11	more	more	ADV
admet-686	249	12	robust	robust	ADJ
admet-686	249	13	estimate	estimate	NOUN
admet-686	249	14	of	of	ADP
admet-686	249	15	the	the	DET
admet-686	249	16	true	true	ADJ
admet-686	249	17	interlaboratory	interlaboratory	NOUN
admet-686	249	18	reproducibility	reproducibility	NOUN
admet-686	249	19	can	can	AUX
admet-686	249	20	be	be	AUX
admet-686	249	21	offered	offer	VERB
admet-686	249	22	here	here	ADV
admet-686	249	23	.	.	PUNCT
admet-686	250	1	improved	improved	ADJ
admet-686	250	2	estimates	estimate	NOUN
admet-686	250	3	[	[	X
admet-686	250	4	4,50	4,50	X
admet-686	250	5	]	]	PUNCT
admet-686	250	6	of	of	ADP
admet-686	250	7	interlaboratory	interlaboratory	ADJ
admet-686	250	8	reproducibility	reproducibility	NOUN
admet-686	250	9	are	be	AUX
admet-686	250	10	better	well	ADV
admet-686	250	11	revealed	reveal	VERB
admet-686	250	12	when	when	SCONJ
admet-686	250	13	solubility	solubility	NOUN
admet-686	250	14	data	datum	NOUN
admet-686	250	15	are	be	AUX
admet-686	250	16	normalized	normalize	VERB
admet-686	250	17	for	for	ADP
admet-686	250	18	ph	ph	PROPN
admet-686	250	19	(	(	PUNCT
admet-686	250	20	to	to	PART
admet-686	250	21	produce	produce	VERB
admet-686	250	22	intrinsic	intrinsic	ADJ
admet-686	250	23	solubility	solubility	NOUN
admet-686	250	24	,	,	PUNCT
admet-686	250	25	s0	s0	PROPN
admet-686	250	26	,	,	PUNCT
admet-686	250	27	derived	derive	VERB
admet-686	250	28	from	from	ADP
admet-686	250	29	water	water	NOUN
admet-686	250	30	solubility	solubility	PROPN
admet-686	250	31	,	,	PUNCT
admet-686	250	32	sw	sw	PROPN
admet-686	250	33	,	,	PUNCT
admet-686	250	34	or	or	CCONJ
admet-686	250	35	multiple	multiple	ADJ
admet-686	250	36	-	-	PUNCT
admet-686	250	37	ph	ph	ADJ
admet-686	250	38	measurements	measurement	NOUN
admet-686	250	39	)	)	PUNCT
admet-686	250	40	and	and	CCONJ
admet-686	250	41	temperature	temperature	NOUN
admet-686	250	42	(	(	PUNCT
admet-686	250	43	by	by	ADP
admet-686	250	44	transforming	transform	VERB
admet-686	250	45	measurements	measurement	NOUN
admet-686	250	46	performed	perform	VERB
admet-686	250	47	in	in	ADP
admet-686	250	48	the	the	DET
admet-686	250	49	range	range	NOUN
admet-686	250	50	10	10	NUM
admet-686	250	51	-	-	SYM
admet-686	250	52	50	50	NUM
admet-686	251	1	°	°	ADP
admet-686	251	2	c	c	NOUN
admet-686	251	3	to	to	ADP
admet-686	251	4	the	the	DET
admet-686	251	5	standard	standard	ADJ
admet-686	251	6	value	value	NOUN
admet-686	251	7	of	of	ADP
admet-686	251	8	25	25	NUM
admet-686	251	9	°	°	NOUN
admet-686	251	10	c	c	NOUN
admet-686	251	11	[	[	X
admet-686	251	12	23	23	NUM
admet-686	251	13	]	]	PUNCT
admet-686	251	14	)	)	PUNCT
admet-686	251	15	.	.	PUNCT
admet-686	252	1	by	by	ADP
admet-686	252	2	way	way	NOUN
admet-686	252	3	of	of	ADP
admet-686	252	4	an	an	DET
admet-686	252	5	addendum	addendum	NOUN
admet-686	252	6	to	to	ADP
admet-686	252	7	the	the	DET
admet-686	252	8	2015	2015	NUM
admet-686	252	9	study	study	NOUN
admet-686	252	10	,	,	PUNCT
admet-686	252	11	the	the	DET
admet-686	252	12	data	data	NOUN
admet-686	252	13	-	-	PUNCT
admet-686	252	14	quality	quality	NOUN
admet-686	252	15	study	study	NOUN
admet-686	252	16	now	now	ADV
admet-686	252	17	has	have	VERB
admet-686	252	18	6355	6355	NUM
admet-686	252	19	intrinsic	intrinsic	ADJ
admet-686	252	20	solubility	solubility	NOUN
admet-686	252	21	entries	entry	NOUN
admet-686	252	22	in	in	ADP
admet-686	252	23	the	the	DET
admet-686	252	24	wiki	wiki	NOUN
admet-686	252	25	-	-	PUNCT
admet-686	252	26	ps0	ps0	ADJ
admet-686	252	27	database	database	NOUN
admet-686	252	28	(	(	PUNCT
admet-686	252	29	in	in	ADP
admet-686	252	30	-	-	PUNCT
admet-686	252	31	adme	adme	NOUN
admet-686	252	32	research	research	NOUN
admet-686	252	33	)	)	PUNCT
admet-686	252	34	,	,	PUNCT
admet-686	252	35	for	for	ADP
admet-686	252	36	3014	3014	NUM
admet-686	252	37	different	different	ADJ
admet-686	252	38	pharmaceutically	pharmaceutically	NOUN
admet-686	252	39	-	-	PUNCT
admet-686	252	40	relevant	relevant	ADJ
admet-686	252	41	molecules	molecule	NOUN
admet-686	252	42	(	(	PUNCT
admet-686	252	43	solids	solid	NOUN
admet-686	252	44	at	at	ADP
admet-686	252	45	room	room	NOUN
admet-686	252	46	temperature	temperature	NOUN
admet-686	252	47	)	)	PUNCT
admet-686	252	48	,	,	PUNCT
admet-686	252	49	drawing	draw	VERB
admet-686	252	50	on	on	ADP
admet-686	252	51	the	the	DET
admet-686	252	52	review	review	NOUN
admet-686	252	53	of	of	ADP
admet-686	252	54	1325	1325	NUM
admet-686	252	55	publications	publication	NOUN
admet-686	252	56	.	.	PUNCT
admet-686	253	1	of	of	ADP
admet-686	253	2	all	all	DET
admet-686	253	3	the	the	DET
admet-686	253	4	entries	entry	NOUN
admet-686	253	5	,	,	PUNCT
admet-686	253	6	2144	2144	NUM
admet-686	253	7	are	be	AUX
admet-686	253	8	singletons	singleton	NOUN
admet-686	253	9	,	,	PUNCT
admet-686	253	10	generally	generally	ADV
admet-686	253	11	reported	report	VERB
admet-686	253	12	as	as	ADP
admet-686	253	13	sw	sw	PROPN
admet-686	253	14	,	,	PUNCT
admet-686	253	15	but	but	CCONJ
admet-686	253	16	transformed	transform	VERB
admet-686	253	17	to	to	ADP
admet-686	253	18	s0	s0	PROPN
admet-686	253	19	,	,	PUNCT
admet-686	253	20	and	and	CCONJ
admet-686	253	21	temperature	temperature	NOUN
admet-686	253	22	adjusted	adjust	VERB
admet-686	253	23	(	(	PUNCT
admet-686	253	24	if	if	SCONJ
admet-686	253	25	needed	need	VERB
admet-686	253	26	)	)	PUNCT
admet-686	253	27	to	to	ADP
admet-686	253	28	25	25	NUM
admet-686	253	29	°	°	NOUN
admet-686	253	30	c	c	NOUN
admet-686	253	31	.	.	PUNCT
admet-686	254	1	these	these	DET
admet-686	254	2	single	single	ADJ
admet-686	254	3	-	-	PUNCT
admet-686	254	4	source	source	NOUN
admet-686	254	5	results	result	NOUN
admet-686	254	6	offer	offer	VERB
admet-686	254	7	no	no	DET
admet-686	254	8	direct	direct	ADJ
admet-686	254	9	indication	indication	NOUN
admet-686	254	10	of	of	ADP
admet-686	254	11	interlaboratory	interlaboratory	ADJ
admet-686	254	12	reproducibility	reproducibility	NOUN
admet-686	254	13	.	.	PUNCT
admet-686	255	1	that	that	DET
admet-686	255	2	indication	indication	NOUN
admet-686	255	3	comes	come	VERB
admet-686	255	4	from	from	ADP
admet-686	255	5	the	the	DET
admet-686	255	6	870	870	NUM
admet-686	255	7	molecules	molecule	NOUN
admet-686	255	8	for	for	ADP
admet-686	255	9	which	which	PRON
admet-686	255	10	solubility	solubility	NOUN
admet-686	255	11	was	be	AUX
admet-686	255	12	reported	report	VERB
admet-686	255	13	from	from	ADP
admet-686	255	14	at	at	ADV
admet-686	255	15	least	least	ADV
admet-686	255	16	two	two	NUM
admet-686	255	17	different	different	ADJ
admet-686	255	18	sources	source	NOUN
admet-686	255	19	.	.	PUNCT
admet-686	256	1	some	some	DET
admet-686	256	2	molecules	molecule	NOUN
admet-686	256	3	have	have	AUX
admet-686	256	4	been	be	AUX
admet-686	256	5	studied	study	VERB
admet-686	256	6	in	in	ADP
admet-686	256	7	surprisingly	surprisingly	ADV
admet-686	256	8	large	large	ADJ
admet-686	256	9	number	number	NOUN
admet-686	256	10	of	of	ADP
admet-686	256	11	different	different	ADJ
admet-686	256	12	laboratories	laboratory	NOUN
admet-686	256	13	.	.	PUNCT
admet-686	257	1	for	for	ADP
admet-686	257	2	example	example	NOUN
admet-686	257	3	,	,	PUNCT
admet-686	257	4	there	there	PRON
admet-686	257	5	were	be	VERB
admet-686	257	6	34	34	NUM
admet-686	257	7	different	different	ADJ
admet-686	257	8	reports	report	NOUN
admet-686	257	9	of	of	ADP
admet-686	257	10	the	the	DET
admet-686	257	11	solubility	solubility	NOUN
admet-686	257	12	of	of	ADP
admet-686	257	13	diclofenac	diclofenac	NOUN
admet-686	257	14	found	find	VERB
admet-686	257	15	to	to	ADP
admet-686	257	16	date	date	NOUN
admet-686	257	17	.	.	PUNCT
admet-686	258	1	seventeen	seventeen	NUM
admet-686	258	2	of	of	ADP
admet-686	258	3	these	these	PRON
admet-686	258	4	were	be	AUX
admet-686	258	5	measured	measure	VERB
admet-686	258	6	at	at	ADP
admet-686	258	7	several	several	ADJ
admet-686	258	8	different	different	ADJ
admet-686	258	9	ph	ph	ADJ
admet-686	258	10	values	value	NOUN
admet-686	258	11	,	,	PUNCT
admet-686	258	12	and	and	CCONJ
admet-686	258	13	are	be	AUX
admet-686	258	14	displayed	display	VERB
admet-686	258	15	in	in	ADP
admet-686	258	16	figure	figure	NOUN
admet-686	258	17	9	9	NUM
admet-686	258	18	.	.	PUNCT
admet-686	259	1	the	the	DET
admet-686	259	2	next	next	ADJ
admet-686	259	3	most	most	ADV
admet-686	259	4	-	-	PUNCT
admet-686	259	5	frequently	frequently	ADV
admet-686	259	6	studied	study	VERB
admet-686	259	7	molecules	molecule	NOUN
admet-686	259	8	appear	appear	VERB
admet-686	259	9	to	to	PART
admet-686	259	10	be	be	AUX
admet-686	259	11	phenytoin	phenytoin	ADJ
admet-686	259	12	,	,	PUNCT
admet-686	259	13	barbital	barbital	NOUN
admet-686	259	14	,	,	PUNCT
admet-686	259	15	and	and	CCONJ
admet-686	259	16	ketoprofen	ketoprofen	VERB
admet-686	259	17	with	with	ADP
admet-686	259	18	30	30	NUM
admet-686	259	19	,	,	PUNCT
admet-686	259	20	26	26	NUM
admet-686	259	21	,	,	PUNCT
admet-686	259	22	and	and	CCONJ
admet-686	259	23	24	24	NUM
admet-686	259	24	interlaboratory	interlaboratory	ADJ
admet-686	259	25	determinations	determination	NOUN
admet-686	259	26	,	,	PUNCT
admet-686	259	27	respectively	respectively	ADV
admet-686	259	28	.	.	PUNCT
admet-686	260	1	the	the	DET
admet-686	260	2	average	average	ADJ
admet-686	260	3	interlaboratory	interlaboratory	NOUN
admet-686	260	4	reproducibility	reproducibility	NOUN
admet-686	260	5	,	,	PUNCT
admet-686	260	6	based	base	VERB
admet-686	260	7	on	on	ADP
admet-686	260	8	the	the	DET
admet-686	260	9	curated	curate	VERB
admet-686	260	10	870	870	NUM
admet-686	260	11	replicated	replicate	VERB
admet-686	260	12	studies	study	NOUN
admet-686	260	13	,	,	PUNCT
admet-686	260	14	has	have	AUX
admet-686	260	15	been	be	AUX
admet-686	260	16	determined	determine	VERB
admet-686	260	17	to	to	PART
admet-686	260	18	be	be	AUX
admet-686	260	19	0.17	0.17	NUM
admet-686	260	20	log	log	NOUN
admet-686	260	21	unit	unit	NOUN
admet-686	260	22	,	,	PUNCT
admet-686	260	23	significantly	significantly	ADV
admet-686	260	24	lower	low	ADJ
admet-686	260	25	than	than	ADP
admet-686	260	26	the	the	DET
admet-686	260	27	interlaboratory	interlaboratory	ADJ
admet-686	260	28	reproducibility	reproducibility	NOUN
admet-686	260	29	(	(	PUNCT
admet-686	260	30	~0.7	~0.7	X
admet-686	260	31	log	log	NOUN
admet-686	260	32	unit	unit	NOUN
admet-686	260	33	)	)	PUNCT
admet-686	260	34	suggested	suggest	VERB
admet-686	260	35	in	in	ADP
admet-686	260	36	past	past	ADJ
admet-686	260	37	studies	study	NOUN
admet-686	260	38	[	[	X
admet-686	260	39	25	25	NUM
admet-686	260	40	]	]	PUNCT
admet-686	260	41	.	.	PUNCT
admet-686	261	1	many	many	ADJ
admet-686	261	2	factors	factor	NOUN
admet-686	261	3	can	can	AUX
admet-686	261	4	lead	lead	VERB
admet-686	261	5	to	to	ADP
admet-686	261	6	the	the	DET
admet-686	261	7	perception	perception	NOUN
admet-686	261	8	of	of	ADP
admet-686	261	9	poor	poor	ADJ
admet-686	261	10	quality	quality	NOUN
admet-686	261	11	of	of	ADP
admet-686	261	12	data	datum	NOUN
admet-686	261	13	.	.	PUNCT
admet-686	262	1	comparing	compare	VERB
admet-686	262	2	“	"	PUNCT
admet-686	262	3	raw	raw	ADJ
admet-686	262	4	”	"	PUNCT
admet-686	262	5	water	water	NOUN
admet-686	262	6	solubilities	solubility	NOUN
admet-686	262	7	(	(	PUNCT
admet-686	262	8	sw	sw	NOUN
admet-686	262	9	)	)	PUNCT
admet-686	262	10	determined	determine	VERB
admet-686	262	11	in	in	ADP
admet-686	262	12	unbuffered	unbuffered	ADJ
admet-686	262	13	solutions	solution	NOUN
admet-686	262	14	can	can	AUX
admet-686	262	15	be	be	AUX
admet-686	262	16	problematic	problematic	ADJ
admet-686	262	17	.	.	PUNCT
admet-686	263	1	for	for	ADP
admet-686	263	2	example	example	NOUN
admet-686	263	3	,	,	PUNCT
admet-686	263	4	using	use	VERB
admet-686	263	5	inaccurate	inaccurate	ADJ
admet-686	263	6	values	value	NOUN
admet-686	263	7	of	of	ADP
admet-686	263	8	pka	pka	PROPN
admet-686	263	9	to	to	PART
admet-686	263	10	interpret	interpret	VERB
admet-686	263	11	the	the	DET
admet-686	263	12	log	log	NOUN
admet-686	263	13	s	s	NOUN
admet-686	263	14	-	-	PUNCT
admet-686	263	15	ph	ph	ADJ
admet-686	263	16	data	datum	NOUN
admet-686	263	17	can	can	AUX
admet-686	263	18	lead	lead	VERB
admet-686	263	19	to	to	ADP
admet-686	263	20	erroneous	erroneous	ADJ
admet-686	263	21	intrinsic	intrinsic	ADJ
admet-686	263	22	solubility	solubility	NOUN
admet-686	263	23	values	value	NOUN
admet-686	263	24	.	.	PUNCT
admet-686	264	1	ambient	ambient	ADJ
admet-686	264	2	levels	level	NOUN
admet-686	264	3	of	of	ADP
admet-686	264	4	carbon	carbon	NOUN
admet-686	264	5	dioxide	dioxide	NOUN
admet-686	264	6	can	can	AUX
admet-686	264	7	significantly	significantly	ADV
admet-686	264	8	affect	affect	VERB
admet-686	264	9	measured	measure	VERB
admet-686	264	10	sw	sw	NOUN
admet-686	264	11	values	value	NOUN
admet-686	264	12	in	in	ADP
admet-686	264	13	the	the	DET
admet-686	264	14	cases	case	NOUN
admet-686	264	15	of	of	ADP
admet-686	264	16	sparingly	sparingly	ADV
admet-686	264	17	soluble	soluble	ADJ
admet-686	264	18	bases	basis	NOUN
admet-686	264	19	.	.	PUNCT
admet-686	265	1	so	so	ADV
admet-686	265	2	can	can	AUX
admet-686	265	3	unsuspected	unsuspected	ADJ
admet-686	265	4	buffer	buffer	NOUN
admet-686	265	5	-	-	PUNCT
admet-686	265	6	drug	drug	NOUN
admet-686	265	7	interactions	interaction	NOUN
admet-686	265	8	,	,	PUNCT
admet-686	265	9	aggregate	aggregate	ADJ
admet-686	265	10	/	/	SYM
admet-686	265	11	micelle	micelle	NOUN
admet-686	265	12	formations	formation	NOUN
admet-686	265	13	,	,	PUNCT
admet-686	265	14	presence	presence	NOUN
admet-686	265	15	of	of	ADP
admet-686	265	16	amorphous	amorphous	ADJ
admet-686	265	17	solids	solid	NOUN
admet-686	265	18	,	,	PUNCT
admet-686	265	19	supersaturated	supersaturated	ADJ
admet-686	265	20	solutions	solution	NOUN
admet-686	265	21	,	,	PUNCT
admet-686	265	22	differences	difference	NOUN
admet-686	265	23	in	in	ADP
admet-686	265	24	the	the	DET
admet-686	265	25	measurement	measurement	NOUN
admet-686	265	26	temperature	temperature	NOUN
admet-686	265	27	,	,	PUNCT
admet-686	265	28	and	and	CCONJ
admet-686	265	29	other	other	ADJ
admet-686	265	30	experimental	experimental	ADJ
admet-686	265	31	conditions	condition	NOUN
admet-686	265	32	.	.	PUNCT
admet-686	266	1	when	when	SCONJ
admet-686	266	2	an	an	DET
admet-686	266	3	effort	effort	NOUN
admet-686	266	4	is	be	AUX
admet-686	266	5	made	make	VERB
admet-686	266	6	to	to	PART
admet-686	266	7	critically	critically	ADV
admet-686	266	8	factor	factor	NOUN
admet-686	266	9	in	in	ADP
admet-686	266	10	the	the	DET
admet-686	266	11	possible	possible	ADJ
admet-686	266	12	sources	source	NOUN
admet-686	266	13	of	of	ADP
admet-686	266	14	systematic	systematic	ADJ
admet-686	266	15	error	error	NOUN
admet-686	266	16	,	,	PUNCT
admet-686	266	17	the	the	DET
admet-686	266	18	interlaboratory	interlaboratory	NOUN
admet-686	266	19	reproducibility	reproducibility	NOUN
admet-686	266	20	is	be	AUX
admet-686	266	21	actually	actually	ADV
admet-686	266	22	quite	quite	ADV
admet-686	266	23	good	good	ADJ
admet-686	266	24	.	.	PUNCT
admet-686	267	1	still	still	ADV
admet-686	267	2	,	,	PUNCT
admet-686	267	3	admet	admet	PROPN
admet-686	267	4	&	&	CCONJ
admet-686	267	5	dmpk	dmpk	PROPN
admet-686	267	6	7(2	7(2	NUM
admet-686	267	7	)	)	PUNCT
admet-686	267	8	(	(	PUNCT
admet-686	267	9	2019	2019	NUM
admet-686	267	10	)	)	PUNCT
admet-686	267	11	88	88	NUM
admet-686	267	12	-	-	SYM
admet-686	267	13	105	105	NUM
admet-686	267	14	perspectives	perspective	NOUN
admet-686	267	15	in	in	ADP
admet-686	267	16	solubility	solubility	NOUN
admet-686	267	17	measurements	measurement	NOUN
admet-686	267	18	and	and	CCONJ
admet-686	267	19	interpretation	interpretation	NOUN
admet-686	267	20	doi	doi	PROPN
admet-686	267	21	:	:	PUNCT
admet-686	267	22	10.5599	10.5599	NUM
admet-686	267	23	/	/	SYM
admet-686	267	24	admet.686	admet.686	PRON
admet-686	267	25	99	99	NUM
admet-686	267	26	for	for	ADP
admet-686	267	27	some	some	DET
admet-686	267	28	drug	drug	NOUN
admet-686	267	29	molecules	molecule	NOUN
admet-686	267	30	,	,	PUNCT
admet-686	267	31	the	the	DET
admet-686	267	32	intrinsic	intrinsic	ADJ
admet-686	267	33	solubility	solubility	NOUN
admet-686	267	34	is	be	AUX
admet-686	267	35	very	very	ADV
admet-686	267	36	uncertain	uncertain	ADJ
admet-686	267	37	,	,	PUNCT
admet-686	267	38	with	with	ADP
admet-686	267	39	standard	standard	ADJ
admet-686	267	40	deviation	deviation	NOUN
admet-686	267	41	(	(	PUNCT
admet-686	267	42	sd	sd	NOUN
admet-686	267	43	)	)	PUNCT
admet-686	267	44	values	value	NOUN
admet-686	267	45	exceeding	exceed	VERB
admet-686	267	46	0.5	0.5	NUM
admet-686	267	47	log	log	NOUN
admet-686	267	48	unit	unit	NOUN
admet-686	267	49	.	.	PUNCT
admet-686	268	1	table	table	NOUN
admet-686	268	2	1	1	NUM
admet-686	268	3	.	.	PUNCT
admet-686	268	4	averaged	average	VERB
admet-686	268	5	intrinsic	intrinsic	ADJ
admet-686	268	6	solubility	solubility	NOUN
admet-686	268	7	of	of	ADP
admet-686	268	8	32	32	NUM
admet-686	268	9	drugs	drug	NOUN
admet-686	268	10	at	at	ADP
admet-686	268	11	25	25	NUM
admet-686	268	12	°	°	NOUN
admet-686	268	13	c	c	NOUN
admet-686	268	14	with	with	ADP
admet-686	268	15	the	the	DET
admet-686	268	16	poorest	poor	ADJ
admet-686	268	17	interlaboratory	interlaboratory	NOUN
admet-686	268	18	reproducibility	reproducibility	NOUN
admet-686	268	19	compound	compound	NOUN
admet-686	268	20	log	log	NOUN
admet-686	268	21	s0	s0	PROPN
admet-686	268	22	25	25	NUM
admet-686	268	23	(	(	PUNCT
admet-686	268	24	m	m	NOUN
admet-686	268	25	)	)	PUNCT
admet-686	268	26	sd	sd	ADP
admet-686	268	27	a	a	DET
admet-686	268	28	n	n	NOUN
admet-686	268	29	b	b	PROPN
admet-686	268	30	compound	compound	NOUN
admet-686	268	31	log	log	NOUN
admet-686	268	32	s0	s0	PROPN
admet-686	268	33	25	25	NUM
admet-686	268	34	(	(	PUNCT
admet-686	268	35	m	m	NOUN
admet-686	268	36	)	)	PUNCT
admet-686	268	37	sd	sd	ADP
admet-686	268	38	n	n	CCONJ
admet-686	268	39	clofazimine	clofazimine	ADJ
admet-686	268	40	-9.05	-9.05	NOUN
admet-686	268	41	0.93	0.93	NUM
admet-686	268	42	5	5	NUM
admet-686	269	1	amiodarone	amiodarone	NOUN
admet-686	269	2	-10.41	-10.41	NOUN
admet-686	269	3	0.59	0.59	NUM
admet-686	269	4	4	4	NUM
admet-686	269	5	telmisartan	telmisartan	NOUN
admet-686	269	6	-6.73	-6.73	NUM
admet-686	269	7	0.84	0.84	NUM
admet-686	269	8	5	5	NUM
admet-686	269	9	saquinavir	saquinavir	NOUN
admet-686	269	10	-5.92	-5.92	NUM
admet-686	269	11	0.58	0.58	NUM
admet-686	269	12	3	3	NUM
admet-686	269	13	buprenorphine	buprenorphine	NOUN
admet-686	269	14	-6.07	-6.07	NUM
admet-686	269	15	0.83	0.83	NUM
admet-686	269	16	3	3	NUM
admet-686	269	17	quinine	quinine	NOUN
admet-686	269	18	-3.06	-3.06	NOUN
admet-686	269	19	0.57	0.57	NUM
admet-686	269	20	7	7	NUM
admet-686	269	21	mifepristone	mifepristone	NOUN
admet-686	269	22	-5.22	-5.22	NUM
admet-686	269	23	0.75	0.75	NUM
admet-686	269	24	4	4	NUM
admet-686	269	25	diflunisal	diflunisal	NOUN
admet-686	269	26	-4.99	-4.99	NUM
admet-686	269	27	0.56	0.56	NUM
admet-686	269	28	11	11	NUM
admet-686	269	29	tamoxifen	tamoxifen	NOUN
admet-686	269	30	-7.52	-7.52	NOUN
admet-686	269	31	0.72	0.72	NUM
admet-686	269	32	7	7	NUM
admet-686	269	33	raloxifene	raloxifene	NOUN
admet-686	269	34	-6.82	-6.82	NUM
admet-686	269	35	0.56	0.56	NUM
admet-686	269	36	6	6	NUM
admet-686	269	37	terfenadine	terfenadine	NOUN
admet-686	269	38	-7.74	-7.74	NUM
admet-686	269	39	0.71	0.71	NUM
admet-686	269	40	11	11	NUM
admet-686	269	41	diphenhydramine	diphenhydramine	NOUN
admet-686	269	42	-3.21	-3.21	NOUN
admet-686	269	43	0.55	0.55	NUM
admet-686	269	44	4	4	NUM
admet-686	269	45	sulfadimethoxine	sulfadimethoxine	NOUN
admet-686	269	46	-3.74	-3.74	NUM
admet-686	269	47	0.70	0.70	NUM
admet-686	269	48	3	3	NUM
admet-686	269	49	etoxadrol	etoxadrol	NOUN
admet-686	269	50	-1.96	-1.96	NUM
admet-686	269	51	0.55	0.55	NUM
admet-686	269	52	3	3	NUM
admet-686	269	53	curcumin	curcumin	NOUN
admet-686	269	54	-5.36	-5.36	NOUN
admet-686	269	55	0.68	0.68	NUM
admet-686	269	56	3	3	NUM
admet-686	269	57	didanosine	didanosine	NOUN
admet-686	269	58	-1.24	-1.24	NOUN
admet-686	269	59	0.54	0.54	NUM
admet-686	269	60	3	3	NUM
admet-686	269	61	rifabutin	rifabutin	NOUN
admet-686	269	62	-4.09	-4.09	PROPN
admet-686	269	63	0.66	0.66	NUM
admet-686	269	64	3	3	NUM
admet-686	269	65	danazol	danazol	ADJ
admet-686	269	66	-6.10	-6.10	NUM
admet-686	269	67	0.52	0.52	NUM
admet-686	269	68	10	10	NUM
admet-686	269	69	iopanoic_acid	iopanoic_acid	ADJ
admet-686	269	70	-5.49	-5.49	ADP
admet-686	269	71	0.66	0.66	NUM
admet-686	269	72	3	3	NUM
admet-686	269	73	ezetimibe	ezetimibe	NOUN
admet-686	269	74	-4.94	-4.94	NUM
admet-686	269	75	0.51	0.51	NUM
admet-686	269	76	4	4	NUM
admet-686	269	77	pioglitazone	pioglitazone	NOUN
admet-686	269	78	-6.20	-6.20	NUM
admet-686	269	79	0.66	0.66	NUM
admet-686	269	80	4	4	NUM
admet-686	269	81	chlorprothixene	chlorprothixene	NOUN
admet-686	269	82	-5.99	-5.99	ADP
admet-686	269	83	0.51	0.51	NUM
admet-686	269	84	6	6	NUM
admet-686	269	85	amodiaquine	amodiaquine	NOUN
admet-686	269	86	-5.49	-5.49	ADP
admet-686	269	87	0.65	0.65	NUM
admet-686	269	88	3	3	NUM
admet-686	269	89	bromocriptine	bromocriptine	NOUN
admet-686	269	90	-5.50	-5.50	NUM
admet-686	269	91	0.51	0.51	NUM
admet-686	269	92	5	5	NUM
admet-686	269	93	fentiazac	fentiazac	NOUN
admet-686	269	94	-5.84	-5.84	NUM
admet-686	269	95	0.65	0.65	NUM
admet-686	269	96	4	4	NUM
admet-686	269	97	miconazole	miconazole	NOUN
admet-686	269	98	-5.82	-5.82	NOUN
admet-686	269	99	0.50	0.50	NUM
admet-686	269	100	6	6	NUM
admet-686	269	101	itraconazole	itraconazole	NOUN
admet-686	269	102	-8.98	-8.98	NUM
admet-686	269	103	0.61	0.61	NUM
admet-686	269	104	3	3	NUM
admet-686	269	105	omeprazole	omeprazole	NOUN
admet-686	269	106	-3.70	-3.70	NUM
admet-686	269	107	0.50	0.50	NUM
admet-686	269	108	3	3	NUM
admet-686	269	109	procaine	procaine	NOUN
admet-686	269	110	-2.30	-2.30	VERB
admet-686	269	111	0.60	0.60	NUM
admet-686	269	112	3	3	NUM
admet-686	269	113	amantadine	amantadine	NOUN
admet-686	269	114	-2.19	-2.19	NUM
admet-686	269	115	0.50	0.50	NUM
admet-686	269	116	3	3	NUM
admet-686	269	117	bisoprolol	bisoprolol	NOUN
admet-686	269	118	-2.09	-2.09	NUM
admet-686	269	119	0.59	0.59	NUM
admet-686	269	120	3	3	NUM
admet-686	269	121	thiabendazole	thiabendazole	NOUN
admet-686	269	122	-3.97	-3.97	NOUN
admet-686	269	123	0.50	0.50	NUM
admet-686	269	124	4	4	NUM
admet-686	269	125	a	a	DET
admet-686	269	126	calculated	calculate	VERB
admet-686	269	127	interlaboratory	interlaboratory	ADJ
admet-686	269	128	standard	standard	ADJ
admet-686	269	129	deviation	deviation	NOUN
admet-686	269	130	.	.	PUNCT
admet-686	270	1	b	b	X
admet-686	270	2	number	number	NOUN
admet-686	270	3	of	of	ADP
admet-686	270	4	reported	report	VERB
admet-686	270	5	studies	study	NOUN
admet-686	270	6	from	from	ADP
admet-686	270	7	different	different	ADJ
admet-686	270	8	laboratories	laboratory	NOUN
admet-686	270	9	.	.	PUNCT
admet-686	271	1	in	in	ADP
admet-686	271	2	addressing	address	VERB
admet-686	271	3	data	datum	NOUN
admet-686	271	4	quality	quality	NOUN
admet-686	271	5	,	,	PUNCT
admet-686	271	6	it	it	PRON
admet-686	271	7	needs	need	VERB
admet-686	271	8	to	to	PART
admet-686	271	9	be	be	AUX
admet-686	271	10	emphasized	emphasize	VERB
admet-686	271	11	that	that	SCONJ
admet-686	271	12	standard	standard	ADJ
admet-686	271	13	conditions	condition	NOUN
admet-686	271	14	are	be	AUX
admet-686	271	15	essential	essential	ADJ
admet-686	271	16	:	:	PUNCT
admet-686	271	17	intrinsic	intrinsic	ADJ
admet-686	271	18	solubility	solubility	NOUN
admet-686	271	19	values	value	NOUN
admet-686	271	20	are	be	AUX
admet-686	271	21	to	to	PART
admet-686	271	22	be	be	AUX
admet-686	271	23	compared	compare	VERB
admet-686	271	24	at	at	ADP
admet-686	271	25	the	the	DET
admet-686	271	26	designated	designate	VERB
admet-686	271	27	reference	reference	NOUN
admet-686	271	28	temperature	temperature	NOUN
admet-686	271	29	of	of	ADP
admet-686	271	30	25	25	NUM
admet-686	271	31	°	°	NOUN
admet-686	271	32	c	c	NOUN
admet-686	271	33	.	.	PUNCT
admet-686	272	1	mixing	mix	VERB
admet-686	272	2	different	different	ADJ
admet-686	272	3	types	type	NOUN
admet-686	272	4	of	of	ADP
admet-686	272	5	solubility	solubility	NOUN
admet-686	272	6	and	and	CCONJ
admet-686	272	7	not	not	PART
admet-686	272	8	normalizing	normalize	VERB
admet-686	272	9	for	for	ADP
admet-686	272	10	temperature	temperature	NOUN
admet-686	272	11	increase	increase	NOUN
admet-686	272	12	the	the	DET
admet-686	272	13	apparent	apparent	ADJ
admet-686	272	14	variance	variance	NOUN
admet-686	272	15	between	between	ADP
admet-686	272	16	different	different	ADJ
admet-686	272	17	laboratory	laboratory	NOUN
admet-686	272	18	results	result	NOUN
admet-686	272	19	,	,	PUNCT
admet-686	272	20	as	as	SCONJ
admet-686	272	21	noted	note	VERB
admet-686	272	22	in	in	ADP
admet-686	272	23	the	the	DET
admet-686	272	24	haloperidol	haloperidol	PROPN
admet-686	272	25	example	example	NOUN
admet-686	272	26	(	(	PUNCT
admet-686	272	27	cf	cf	NOUN
admet-686	272	28	.	.	PUNCT
admet-686	272	29	,	,	PUNCT
admet-686	272	30	fig	fig	NOUN
admet-686	272	31	.	.	PUNCT
admet-686	272	32	1	1	NUM
admet-686	272	33	)	)	PUNCT
admet-686	272	34	.	.	PUNCT
admet-686	273	1	although	although	SCONJ
admet-686	273	2	the	the	DET
admet-686	273	3	realistic	realistic	ADJ
admet-686	273	4	average	average	ADJ
admet-686	273	5	interlaboratory	interlaboratory	NOUN
admet-686	273	6	reproducibility	reproducibility	NOUN
admet-686	273	7	is	be	AUX
admet-686	273	8	relatively	relatively	ADV
admet-686	273	9	good	good	ADJ
admet-686	273	10	,	,	PUNCT
admet-686	273	11	some	some	DET
admet-686	273	12	low	low	ADJ
admet-686	273	13	-	-	PUNCT
admet-686	273	14	soluble	soluble	ADJ
admet-686	273	15	molecules	molecule	NOUN
admet-686	273	16	are	be	AUX
admet-686	273	17	still	still	ADV
admet-686	273	18	problematic	problematic	ADJ
admet-686	273	19	.	.	PUNCT
admet-686	274	1	table	table	NOUN
admet-686	274	2	1	1	NUM
admet-686	274	3	lists	list	VERB
admet-686	274	4	the	the	DET
admet-686	274	5	32	32	NUM
admet-686	274	6	compounds	compound	NOUN
admet-686	274	7	with	with	ADP
admet-686	274	8	the	the	DET
admet-686	274	9	poorest	poor	ADJ
admet-686	274	10	reproducibility	reproducibility	NOUN
admet-686	274	11	,	,	PUNCT
admet-686	274	12	drawing	draw	VERB
admet-686	274	13	on	on	ADP
admet-686	274	14	sources	source	NOUN
admet-686	274	15	where	where	SCONJ
admet-686	274	16	at	at	ADV
admet-686	274	17	least	least	ADV
admet-686	274	18	three	three	NUM
admet-686	274	19	different	different	ADJ
admet-686	274	20	studies	study	NOUN
admet-686	274	21	were	be	AUX
admet-686	274	22	reported	report	VERB
admet-686	274	23	.	.	PUNCT
admet-686	275	1	at	at	ADP
admet-686	275	2	the	the	DET
admet-686	275	3	top	top	NOUN
admet-686	275	4	of	of	ADP
admet-686	275	5	the	the	DET
admet-686	275	6	list	list	NOUN
admet-686	275	7	is	be	AUX
admet-686	275	8	clofazimine	clofazimine	ADJ
admet-686	275	9	.	.	PUNCT
admet-686	276	1	based	base	VERB
admet-686	276	2	on	on	ADP
admet-686	276	3	five	five	NUM
admet-686	276	4	reported	report	VERB
admet-686	276	5	values	value	NOUN
admet-686	276	6	,	,	PUNCT
admet-686	276	7	the	the	DET
admet-686	276	8	standard	standard	ADJ
admet-686	276	9	deviation	deviation	NOUN
admet-686	276	10	is	be	AUX
admet-686	276	11	0.93	0.93	NUM
admet-686	276	12	log	log	NOUN
admet-686	276	13	unit	unit	NOUN
admet-686	276	14	.	.	PUNCT
admet-686	277	1	similarly	similarly	ADV
admet-686	277	2	,	,	PUNCT
admet-686	277	3	even	even	ADV
admet-686	277	4	though	though	SCONJ
admet-686	277	5	terfenadine	terfenadine	NOUN
admet-686	277	6	solubility	solubility	NOUN
admet-686	277	7	has	have	AUX
admet-686	277	8	been	be	AUX
admet-686	277	9	reported	report	VERB
admet-686	277	10	in	in	ADP
admet-686	277	11	eleven	eleven	NUM
admet-686	277	12	studies	study	NOUN
admet-686	277	13	,	,	PUNCT
admet-686	277	14	its	its	PRON
admet-686	277	15	interlaboratory	interlaboratory	ADJ
admet-686	277	16	reproducibility	reproducibility	NOUN
admet-686	277	17	at	at	ADP
admet-686	277	18	0.71	0.71	NUM
admet-686	277	19	is	be	AUX
admet-686	277	20	still	still	ADV
admet-686	277	21	high	high	ADJ
admet-686	277	22	.	.	PUNCT
admet-686	278	1	still	still	ADV
admet-686	278	2	,	,	PUNCT
admet-686	278	3	32	32	NUM
admet-686	278	4	out	out	ADP
admet-686	278	5	of	of	ADP
admet-686	278	6	3014	3014	NUM
admet-686	278	7	molecules	molecule	NOUN
admet-686	278	8	is	be	AUX
admet-686	278	9	a	a	DET
admet-686	278	10	small	small	ADJ
admet-686	278	11	fraction	fraction	NOUN
admet-686	278	12	.	.	PUNCT
admet-686	279	1	the	the	DET
admet-686	279	2	rest	rest	NOUN
admet-686	279	3	of	of	ADP
admet-686	279	4	the	the	DET
admet-686	279	5	molecules	molecule	NOUN
admet-686	279	6	are	be	AUX
admet-686	279	7	much	much	ADV
admet-686	279	8	better	well	ADV
admet-686	279	9	determined	determine	VERB
admet-686	279	10	.	.	PUNCT
admet-686	280	1	absent	absent	ADJ
admet-686	280	2	from	from	ADP
admet-686	280	3	the	the	DET
admet-686	280	4	list	list	NOUN
admet-686	280	5	in	in	ADP
admet-686	280	6	table	table	NOUN
admet-686	280	7	1	1	NUM
admet-686	280	8	is	be	AUX
admet-686	280	9	diclofenac	diclofenac	NOUN
admet-686	280	10	,	,	PUNCT
admet-686	280	11	because	because	SCONJ
admet-686	280	12	its	its	PRON
admet-686	280	13	intrinsic	intrinsic	ADJ
admet-686	280	14	solubility	solubility	NOUN
admet-686	280	15	has	have	VERB
admet-686	280	16	a	a	DET
admet-686	280	17	tight	tight	ADJ
admet-686	280	18	consensus	consensus	NOUN
admet-686	280	19	value	value	NOUN
admet-686	280	20	.	.	PUNCT
admet-686	281	1	its	its	PRON
admet-686	281	2	averaged	average	VERB
admet-686	281	3	log	log	NOUN
admet-686	281	4	s0	s0	PROPN
admet-686	281	5	25	25	NUM
admet-686	281	6	=	=	SYM
admet-686	281	7	-5.34	-5.34	NUM
admet-686	281	8	±0.18	±0.18	NOUN
admet-686	281	9	,	,	PUNCT
admet-686	281	10	based	base	VERB
admet-686	281	11	on	on	ADP
admet-686	281	12	34	34	NUM
admet-686	281	13	published	publish	VERB
admet-686	281	14	studies	study	NOUN
admet-686	281	15	.	.	PUNCT
admet-686	282	1	the	the	DET
admet-686	282	2	standard	standard	ADJ
admet-686	282	3	deviation	deviation	NOUN
admet-686	282	4	is	be	AUX
admet-686	282	5	almost	almost	ADV
admet-686	282	6	identical	identical	ADJ
admet-686	282	7	to	to	ADP
admet-686	282	8	the	the	DET
admet-686	282	9	estimated	estimate	VERB
admet-686	282	10	interlaboratory	interlaboratory	ADJ
admet-686	282	11	reproducibility	reproducibility	NOUN
admet-686	282	12	of	of	ADP
admet-686	282	13	0.17	0.17	NUM
admet-686	282	14	.	.	PUNCT
admet-686	283	1	thus	thus	ADV
admet-686	283	2	,	,	PUNCT
admet-686	283	3	the	the	DET
admet-686	283	4	diclofenac	diclofenac	NOUN
admet-686	283	5	data	datum	NOUN
admet-686	283	6	from	from	ADP
admet-686	283	7	different	different	ADJ
admet-686	283	8	laboratories	laboratory	NOUN
admet-686	283	9	offer	offer	VERB
admet-686	283	10	an	an	DET
admet-686	283	11	opportunity	opportunity	NOUN
admet-686	283	12	to	to	PART
admet-686	283	13	examine	examine	VERB
admet-686	283	14	issues	issue	NOUN
admet-686	283	15	that	that	PRON
admet-686	283	16	affect	affect	VERB
admet-686	283	17	the	the	DET
admet-686	283	18	quality	quality	NOUN
admet-686	283	19	of	of	ADP
admet-686	283	20	solubility	solubility	NOUN
admet-686	283	21	measurements	measurement	NOUN
admet-686	283	22	as	as	ADP
admet-686	283	23	a	a	DET
admet-686	283	24	whole	whole	NOUN
admet-686	283	25	.	.	PUNCT
admet-686	284	1	that	that	PRON
admet-686	284	2	is	be	AUX
admet-686	284	3	,	,	PUNCT
admet-686	284	4	many	many	ADJ
admet-686	284	5	of	of	ADP
admet-686	284	6	the	the	DET
admet-686	284	7	possible	possible	ADJ
admet-686	284	8	challenges	challenge	NOUN
admet-686	284	9	in	in	ADP
admet-686	284	10	the	the	DET
admet-686	284	11	interpretation	interpretation	NOUN
admet-686	284	12	of	of	ADP
admet-686	284	13	data	datum	NOUN
admet-686	284	14	in	in	ADP
admet-686	284	15	the	the	DET
admet-686	284	16	assessment	assessment	NOUN
admet-686	284	17	of	of	ADP
admet-686	284	18	interlaboratory	interlaboratory	ADJ
admet-686	284	19	reproducibility	reproducibility	NOUN
admet-686	284	20	can	can	AUX
admet-686	284	21	be	be	AUX
admet-686	284	22	revealed	reveal	VERB
admet-686	284	23	in	in	ADP
admet-686	284	24	the	the	DET
admet-686	284	25	examination	examination	NOUN
admet-686	284	26	of	of	ADP
admet-686	284	27	diclofenac	diclofenac	NOUN
admet-686	284	28	.	.	PUNCT
admet-686	285	1	it	it	PRON
admet-686	285	2	is	be	AUX
admet-686	285	3	evident	evident	ADJ
admet-686	285	4	that	that	SCONJ
admet-686	285	5	several	several	ADJ
admet-686	285	6	different	different	ADJ
admet-686	285	7	patterns	pattern	NOUN
admet-686	285	8	of	of	ADP
admet-686	285	9	distortion	distortion	NOUN
admet-686	285	10	occur	occur	VERB
admet-686	285	11	in	in	ADP
admet-686	285	12	the	the	DET
admet-686	285	13	diclofenac	diclofenac	NOUN
admet-686	285	14	log	log	NOUN
admet-686	285	15	s	s	ADJ
admet-686	285	16	-	-	PUNCT
admet-686	285	17	ph	ph	ADJ
admet-686	285	18	profiles	profile	NOUN
admet-686	285	19	in	in	ADP
admet-686	285	20	figure	figure	NOUN
admet-686	285	21	9	9	NUM
admet-686	285	22	which	which	PRON
admet-686	285	23	can	can	AUX
admet-686	285	24	not	not	PART
admet-686	285	25	be	be	AUX
admet-686	285	26	predicted	predict	VERB
admet-686	285	27	by	by	ADP
admet-686	285	28	the	the	DET
admet-686	285	29	henderson	henderson	PROPN
admet-686	285	30	-	-	PUNCT
admet-686	285	31	hasselbalch	hasselbalch	PROPN
admet-686	285	32	equation	equation	NOUN
admet-686	285	33	.	.	PUNCT
admet-686	286	1	one	one	NUM
admet-686	286	2	case	case	NOUN
admet-686	286	3	,	,	PUNCT
admet-686	286	4	in	in	ADP
admet-686	286	5	figure	figure	NOUN
admet-686	286	6	9	9	NUM
admet-686	286	7	g	g	NOUN
admet-686	286	8	,	,	PUNCT
admet-686	286	9	shows	show	VERB
admet-686	286	10	distortion	distortion	NOUN
admet-686	286	11	similar	similar	ADJ
admet-686	286	12	to	to	ADP
admet-686	286	13	those	those	PRON
admet-686	286	14	shown	show	VERB
admet-686	286	15	in	in	ADP
admet-686	286	16	figure	figure	NOUN
admet-686	286	17	5	5	NUM
admet-686	286	18	,	,	PUNCT
admet-686	286	19	suggestive	suggestive	ADJ
admet-686	286	20	of	of	ADP
admet-686	286	21	charge	charge	NOUN
admet-686	286	22	-	-	PUNCT
admet-686	286	23	species	species	NOUN
admet-686	286	24	aggregation	aggregation	NOUN
admet-686	286	25	reaction	reaction	NOUN
admet-686	286	26	.	.	PUNCT
admet-686	287	1	the	the	DET
admet-686	287	2	data	datum	NOUN
admet-686	287	3	can	can	AUX
admet-686	287	4	be	be	AUX
admet-686	287	5	rationalized	rationalize	VERB
admet-686	287	6	by	by	ADP
admet-686	287	7	the	the	DET
admet-686	287	8	formation	formation	NOUN
admet-686	287	9	of	of	ADP
admet-686	287	10	the	the	DET
admet-686	287	11	hexameric	hexameric	NOUN
admet-686	287	12	diclofenac	diclofenac	NOUN
admet-686	287	13	anion	anion	NOUN
admet-686	287	14	complex	complex	NOUN
admet-686	287	15	associated	associate	VERB
admet-686	287	16	with	with	ADP
admet-686	287	17	three	three	NUM
admet-686	287	18	protonated	protonate	VERB
admet-686	287	19	1-(2	1-(2	PROPN
admet-686	287	20	-	-	PUNCT
admet-686	287	21	hydroxyethyl)pyrrolidine	hydroxyethyl)pyrrolidine	PROPN
admet-686	287	22	cations	cation	NOUN
admet-686	287	23	.	.	PUNCT
admet-686	288	1	the	the	DET
admet-686	288	2	points	point	NOUN
admet-686	288	3	with	with	ADP
admet-686	288	4	the	the	DET
admet-686	288	5	highest	high	ADJ
admet-686	288	6	solubility	solubility	NOUN
admet-686	288	7	(	(	PUNCT
admet-686	288	8	above	above	ADP
admet-686	288	9	the	the	DET
admet-686	288	10	solid	solid	ADJ
admet-686	288	11	curve	curve	NOUN
admet-686	288	12	)	)	PUNCT
admet-686	288	13	appear	appear	VERB
admet-686	288	14	to	to	PART
admet-686	288	15	be	be	AUX
admet-686	288	16	indicative	indicative	ADJ
admet-686	288	17	of	of	ADP
admet-686	288	18	supersaturation	supersaturation	NOUN
admet-686	288	19	,	,	PUNCT
admet-686	288	20	and	and	CCONJ
admet-686	288	21	could	could	AUX
admet-686	288	22	not	not	PART
admet-686	288	23	be	be	AUX
admet-686	288	24	explained	explain	VERB
admet-686	288	25	by	by	ADP
admet-686	288	26	a	a	DET
admet-686	288	27	simple	simple	ADJ
admet-686	288	28	equilibrium	equilibrium	NOUN
admet-686	288	29	model	model	NOUN
admet-686	288	30	.	.	PUNCT
admet-686	289	1	distortions	distortion	NOUN
admet-686	289	2	involving	involve	VERB
admet-686	289	3	the	the	DET
admet-686	289	4	free	free	ADJ
admet-686	289	5	acid	acid	NOUN
admet-686	289	6	are	be	AUX
admet-686	289	7	evident	evident	ADJ
admet-686	289	8	in	in	ADP
admet-686	289	9	figures	figure	NOUN
admet-686	289	10	9f	9f	NUM
admet-686	289	11	-	-	PUNCT
admet-686	289	12	o	o	NOUN
admet-686	289	13	,	,	PUNCT
admet-686	289	14	which	which	PRON
admet-686	289	15	show	show	VERB
admet-686	289	16	elevated	elevated	ADJ
admet-686	289	17	solubility	solubility	NOUN
admet-686	289	18	in	in	ADP
admet-686	289	19	low	low	ADJ
admet-686	289	20	-	-	PUNCT
admet-686	289	21	ph	ph	ADJ
admet-686	289	22	region	region	NOUN
admet-686	289	23	,	,	PUNCT
admet-686	289	24	above	above	ADP
admet-686	289	25	that	that	PRON
admet-686	289	26	indicated	indicate	VERB
admet-686	289	27	by	by	ADP
admet-686	289	28	the	the	DET
admet-686	289	29	dashed	dash	VERB
admet-686	289	30	hh	hh	ADJ
admet-686	289	31	-	-	PUNCT
admet-686	289	32	calculated	calculate	VERB
admet-686	289	33	curve	curve	NOUN
admet-686	289	34	.	.	PUNCT
admet-686	290	1	these	these	PRON
admet-686	290	2	may	may	AUX
admet-686	290	3	indicate	indicate	VERB
admet-686	290	4	amorphous	amorphous	ADJ
admet-686	290	5	phase	phase	NOUN
admet-686	290	6	solubility	solubility	NOUN
admet-686	290	7	(	(	PUNCT
admet-686	290	8	cf	cf	NOUN
admet-686	290	9	.	.	PUNCT
admet-686	290	10	,	,	PUNCT
admet-686	290	11	figure	figure	VERB
admet-686	290	12	1a	1a	NOUN
admet-686	290	13	,	,	PUNCT
admet-686	290	14	d	d	NOUN
admet-686	290	15	)	)	PUNCT
admet-686	290	16	.	.	PUNCT
admet-686	291	1	in	in	ADP
admet-686	291	2	some	some	DET
admet-686	291	3	cases	case	NOUN
admet-686	291	4	,	,	PUNCT
admet-686	291	5	the	the	DET
admet-686	291	6	effect	effect	NOUN
admet-686	291	7	may	may	AUX
admet-686	291	8	be	be	AUX
admet-686	291	9	due	due	ADJ
admet-686	291	10	to	to	ADP
admet-686	291	11	the	the	DET
admet-686	291	12	limit	limit	NOUN
admet-686	291	13	of	of	ADP
admet-686	291	14	detection	detection	NOUN
admet-686	291	15	in	in	ADP
admet-686	291	16	the	the	DET
admet-686	291	17	analytical	analytical	ADJ
admet-686	291	18	technique	technique	NOUN
admet-686	291	19	used	use	VERB
admet-686	291	20	to	to	PART
admet-686	291	21	measure	measure	VERB
admet-686	291	22	the	the	DET
admet-686	291	23	concentration	concentration	NOUN
admet-686	291	24	of	of	ADP
admet-686	291	25	the	the	DET
admet-686	291	26	practically	practically	ADV
admet-686	291	27	-	-	PUNCT
admet-686	291	28	insoluble	insoluble	ADJ
admet-686	291	29	drug	drug	NOUN
admet-686	291	30	.	.	PUNCT
admet-686	292	1	bergström	bergström	NOUN
admet-686	292	2	and	and	CCONJ
admet-686	292	3	avdeef	avdeef	PROPN
admet-686	292	4	admet	admet	PROPN
admet-686	292	5	&	&	CCONJ
admet-686	292	6	dmpk	dmpk	PROPN
admet-686	292	7	7(2	7(2	NUM
admet-686	292	8	)	)	PUNCT
admet-686	292	9	(	(	PUNCT
admet-686	292	10	2019	2019	NUM
admet-686	292	11	)	)	PUNCT
admet-686	292	12	88	88	NUM
admet-686	292	13	-	-	SYM
admet-686	292	14	105	105	NUM
admet-686	292	15	100	100	NUM
admet-686	292	16	different	different	ADJ
admet-686	292	17	solubility	solubility	NOUN
admet-686	292	18	methods	method	NOUN
admet-686	292	19	were	be	AUX
admet-686	292	20	used	use	VERB
admet-686	292	21	to	to	PART
admet-686	292	22	collect	collect	VERB
admet-686	292	23	the	the	DET
admet-686	292	24	data	datum	NOUN
admet-686	292	25	in	in	ADP
admet-686	292	26	the	the	DET
admet-686	292	27	figures	figure	NOUN
admet-686	292	28	.	.	PUNCT
admet-686	293	1	figure	figure	NOUN
admet-686	293	2	9a	9a	NOUN
admet-686	293	3	is	be	AUX
admet-686	293	4	based	base	VERB
admet-686	293	5	on	on	ADP
admet-686	293	6	hts	hts	PROPN
admet-686	293	7	data	data	PROPN
admet-686	293	8	(	(	PUNCT
admet-686	293	9	μsol	μsol	NOUN
admet-686	293	10	method	method	NOUN
admet-686	293	11	)	)	PUNCT
admet-686	293	12	–	–	PUNCT
admet-686	293	13	there	there	PRON
admet-686	293	14	are	be	VERB
admet-686	293	15	many	many	ADJ
admet-686	293	16	points	point	NOUN
admet-686	293	17	in	in	ADP
admet-686	293	18	the	the	DET
admet-686	293	19	plot	plot	NOUN
admet-686	293	20	,	,	PUNCT
admet-686	293	21	but	but	CCONJ
admet-686	293	22	they	they	PRON
admet-686	293	23	show	show	VERB
admet-686	293	24	considerable	considerable	ADJ
admet-686	293	25	scatter	scatter	NOUN
admet-686	293	26	.	.	PUNCT
admet-686	294	1	the	the	DET
admet-686	294	2	rest	rest	NOUN
admet-686	294	3	of	of	ADP
admet-686	294	4	the	the	DET
admet-686	294	5	examples	example	NOUN
admet-686	294	6	are	be	AUX
admet-686	294	7	based	base	VERB
admet-686	294	8	on	on	ADP
admet-686	294	9	shake	shake	NOUN
admet-686	294	10	-	-	PUNCT
admet-686	294	11	flask	flask	NOUN
admet-686	294	12	measurement	measurement	NOUN
admet-686	294	13	.	.	PUNCT
admet-686	295	1	also	also	ADV
admet-686	295	2	,	,	PUNCT
admet-686	295	3	the	the	DET
admet-686	295	4	temperature	temperature	NOUN
admet-686	295	5	is	be	AUX
admet-686	295	6	not	not	PART
admet-686	295	7	the	the	DET
admet-686	295	8	same	same	ADJ
admet-686	295	9	in	in	ADP
admet-686	295	10	the	the	DET
admet-686	295	11	figure	figure	NOUN
admet-686	295	12	.	.	PUNCT
admet-686	296	1	two	two	NUM
admet-686	296	2	of	of	ADP
admet-686	296	3	the	the	DET
admet-686	296	4	studies	study	NOUN
admet-686	296	5	were	be	AUX
admet-686	296	6	done	do	VERB
admet-686	296	7	at	at	ADP
admet-686	296	8	22	22	NUM
admet-686	296	9	°	°	NOUN
admet-686	296	10	c	c	NOUN
admet-686	296	11	,	,	PUNCT
admet-686	296	12	four	four	NUM
admet-686	296	13	at	at	ADP
admet-686	296	14	23	23	NUM
admet-686	296	15	°	°	ADP
admet-686	296	16	c	c	X
admet-686	296	17	(	(	PUNCT
admet-686	296	18	‘	'	PUNCT
admet-686	296	19	room	room	NOUN
admet-686	296	20	temperature	temperature	NOUN
admet-686	296	21	’	'	PUNCT
admet-686	296	22	)	)	PUNCT
admet-686	296	23	,	,	PUNCT
admet-686	296	24	ten	ten	NUM
admet-686	296	25	at	at	ADP
admet-686	296	26	25	25	NUM
admet-686	296	27	°	°	NOUN
admet-686	296	28	c	c	NOUN
admet-686	296	29	,	,	PUNCT
admet-686	296	30	and	and	CCONJ
admet-686	296	31	one	one	NUM
admet-686	296	32	at	at	ADP
admet-686	296	33	37	37	NUM
admet-686	296	34	°	°	NOUN
admet-686	296	35	c	c	NOUN
admet-686	296	36	.	.	PUNCT
admet-686	297	1	figure	figure	NOUN
admet-686	297	2	9	9	NUM
admet-686	297	3	.	.	PUNCT
admet-686	298	1	the	the	DET
admet-686	298	2	diclofenac	diclofenac	NOUN
admet-686	298	3	log	log	NOUN
admet-686	298	4	s	s	NOUN
admet-686	298	5	-	-	PUNCT
admet-686	298	6	ph	ph	ADJ
admet-686	298	7	measurements	measurement	NOUN
admet-686	298	8	from	from	ADP
admet-686	298	9	17	17	NUM
admet-686	298	10	publications	publication	NOUN
admet-686	298	11	[	[	X
admet-686	298	12	28,51	28,51	NUM
admet-686	298	13	-	-	SYM
admet-686	298	14	64	64	NUM
admet-686	298	15	]	]	PUNCT
admet-686	298	16	reveal	reveal	VERB
admet-686	298	17	a	a	DET
admet-686	298	18	plethora	plethora	NOUN
admet-686	298	19	of	of	ADP
admet-686	298	20	effects	effect	NOUN
admet-686	298	21	that	that	PRON
admet-686	298	22	might	might	AUX
admet-686	298	23	lead	lead	VERB
admet-686	298	24	to	to	ADP
admet-686	298	25	poor	poor	ADJ
admet-686	298	26	reproducibility	reproducibility	NOUN
admet-686	298	27	in	in	ADP
admet-686	298	28	the	the	DET
admet-686	298	29	determination	determination	NOUN
admet-686	298	30	of	of	ADP
admet-686	298	31	the	the	DET
admet-686	298	32	intrinsic	intrinsic	ADJ
admet-686	298	33	solubility	solubility	NOUN
admet-686	298	34	.	.	PUNCT
admet-686	299	1	see	see	VERB
admet-686	299	2	text	text	NOUN
admet-686	299	3	for	for	ADP
admet-686	299	4	details	detail	NOUN
admet-686	299	5	.	.	PUNCT
admet-686	300	1	admet	admet	PROPN
admet-686	300	2	&	&	CCONJ
admet-686	300	3	dmpk	dmpk	PROPN
admet-686	300	4	7(2	7(2	NUM
admet-686	300	5	)	)	PUNCT
admet-686	300	6	(	(	PUNCT
admet-686	300	7	2019	2019	NUM
admet-686	300	8	)	)	PUNCT
admet-686	300	9	88	88	NUM
admet-686	300	10	-	-	SYM
admet-686	300	11	105	105	NUM
admet-686	300	12	perspectives	perspective	NOUN
admet-686	300	13	in	in	ADP
admet-686	300	14	solubility	solubility	NOUN
admet-686	300	15	measurements	measurement	NOUN
admet-686	300	16	and	and	CCONJ
admet-686	300	17	interpretation	interpretation	NOUN
admet-686	300	18	doi	doi	PROPN
admet-686	300	19	:	:	PUNCT
admet-686	300	20	10.5599	10.5599	NUM
admet-686	300	21	/	/	SYM
admet-686	300	22	admet.686	admet.686	PROPN
admet-686	300	23	101	101	NUM
admet-686	300	24	the	the	DET
admet-686	300	25	rigorous	rigorous	ADJ
admet-686	300	26	regression	regression	NOUN
admet-686	300	27	analysis	analysis	NOUN
admet-686	300	28	of	of	ADP
admet-686	300	29	the	the	DET
admet-686	300	30	data	datum	NOUN
admet-686	300	31	in	in	ADP
admet-686	300	32	the	the	DET
admet-686	300	33	figures	figure	NOUN
admet-686	300	34	,	,	PUNCT
admet-686	300	35	taking	take	VERB
admet-686	300	36	into	into	ADP
admet-686	300	37	account	account	NOUN
admet-686	300	38	all	all	DET
admet-686	300	39	relevant	relevant	ADJ
admet-686	300	40	reactions	reaction	NOUN
admet-686	300	41	in	in	ADP
admet-686	300	42	the	the	DET
admet-686	300	43	equilibrium	equilibrium	NOUN
admet-686	300	44	model	model	NOUN
admet-686	301	1	[	[	X
admet-686	301	2	22	22	NUM
admet-686	301	3	]	]	PUNCT
admet-686	301	4	,	,	PUNCT
admet-686	301	5	produced	produce	VERB
admet-686	301	6	the	the	DET
admet-686	301	7	intrinsic	intrinsic	ADJ
admet-686	301	8	solubility	solubility	NOUN
admet-686	301	9	values	value	NOUN
admet-686	301	10	indicated	indicate	VERB
admet-686	301	11	in	in	ADP
admet-686	301	12	each	each	DET
admet-686	301	13	frame	frame	NOUN
admet-686	301	14	of	of	ADP
admet-686	301	15	figure	figure	NOUN
admet-686	301	16	9	9	NUM
admet-686	301	17	.	.	PUNCT
admet-686	302	1	when	when	SCONJ
admet-686	302	2	these	these	DET
admet-686	302	3	values	value	NOUN
admet-686	302	4	are	be	AUX
admet-686	302	5	further	far	ADV
admet-686	302	6	transformed	transform	VERB
admet-686	302	7	to	to	ADP
admet-686	302	8	a	a	DET
admet-686	302	9	common	common	ADJ
admet-686	302	10	reference	reference	NOUN
admet-686	302	11	temperature	temperature	NOUN
admet-686	302	12	of	of	ADP
admet-686	302	13	25	25	NUM
admet-686	302	14	°	°	NOUN
admet-686	302	15	c	c	NOUN
admet-686	302	16	[	[	X
admet-686	302	17	23	23	NUM
admet-686	302	18	]	]	PUNCT
admet-686	302	19	,	,	PUNCT
admet-686	302	20	the	the	DET
admet-686	302	21	resultant	resultant	NOUN
admet-686	302	22	mean	mean	NOUN
admet-686	302	23	value	value	NOUN
admet-686	302	24	of	of	ADP
admet-686	302	25	the	the	DET
admet-686	302	26	17	17	NUM
admet-686	302	27	cases	case	NOUN
admet-686	302	28	turns	turn	VERB
admet-686	302	29	out	out	ADP
admet-686	302	30	to	to	PART
admet-686	302	31	be	be	AUX
admet-686	302	32	log	log	NOUN
admet-686	302	33	s0	s0	PROPN
admet-686	302	34	25	25	NUM
admet-686	303	1	=	=	SYM
admet-686	303	2	-5.30	-5.30	PRON
admet-686	303	3	±0.17	±0.17	PROPN
admet-686	303	4	(	(	PUNCT
admet-686	303	5	1.6	1.6	NUM
admet-686	303	6	±	±	NUM
admet-686	303	7	0.6	0.6	NUM
admet-686	303	8	μg	μg	NOUN
admet-686	303	9	/	/	SYM
admet-686	303	10	ml	ml	NOUN
admet-686	303	11	)	)	PUNCT
admet-686	303	12	.	.	PUNCT
admet-686	304	1	this	this	DET
admet-686	304	2	mean	mean	NOUN
admet-686	304	3	is	be	AUX
admet-686	304	4	essentially	essentially	ADV
admet-686	304	5	the	the	DET
admet-686	304	6	same	same	ADJ
admet-686	304	7	as	as	ADP
admet-686	304	8	the	the	DET
admet-686	304	9	one	one	NOUN
admet-686	304	10	obtained	obtain	VERB
admet-686	304	11	from	from	ADP
admet-686	304	12	the	the	DET
admet-686	304	13	averaging	averaging	NOUN
admet-686	304	14	all	all	PRON
admet-686	304	15	34	34	NUM
admet-686	304	16	cited	cite	VERB
admet-686	304	17	values	value	NOUN
admet-686	304	18	,	,	PUNCT
admet-686	304	19	as	as	SCONJ
admet-686	304	20	noted	note	VERB
admet-686	304	21	above	above	ADV
admet-686	304	22	.	.	PUNCT
admet-686	305	1	the	the	DET
admet-686	305	2	above	above	ADJ
admet-686	305	3	standard	standard	ADJ
admet-686	305	4	deviation	deviation	NOUN
admet-686	305	5	of	of	ADP
admet-686	305	6	the	the	DET
admet-686	305	7	mean	mean	NOUN
admet-686	305	8	is	be	AUX
admet-686	305	9	identical	identical	ADJ
admet-686	305	10	to	to	ADP
admet-686	305	11	the	the	DET
admet-686	305	12	interlaboratory	interlaboratory	ADJ
admet-686	305	13	reproducibility	reproducibility	NOUN
admet-686	305	14	obtained	obtain	VERB
admet-686	305	15	from	from	ADP
admet-686	305	16	the	the	DET
admet-686	305	17	analysis	analysis	NOUN
admet-686	305	18	of	of	ADP
admet-686	305	19	870	870	NUM
admet-686	305	20	different	different	ADJ
admet-686	305	21	molecules	molecule	NOUN
admet-686	305	22	,	,	PUNCT
admet-686	305	23	and	and	CCONJ
admet-686	305	24	is	be	AUX
admet-686	305	25	quite	quite	DET
admet-686	305	26	a	a	DET
admet-686	305	27	bit	bit	NOUN
admet-686	305	28	lower	low	ADJ
admet-686	305	29	than	than	ADP
admet-686	305	30	the	the	DET
admet-686	305	31	frequently	frequently	ADV
admet-686	305	32	cited	cite	VERB
admet-686	305	33	uncertainty	uncertainty	NOUN
admet-686	305	34	of	of	ADP
admet-686	305	35	~0.7	~0.7	NUM
admet-686	305	36	log	log	NOUN
admet-686	305	37	unit	unit	NOUN
admet-686	305	38	in	in	ADP
admet-686	305	39	solubility	solubility	NOUN
admet-686	305	40	measurement	measurement	NOUN
admet-686	305	41	,	,	PUNCT
admet-686	305	42	when	when	SCONJ
admet-686	305	43	comparing	compare	VERB
admet-686	305	44	results	result	NOUN
admet-686	305	45	from	from	ADP
admet-686	305	46	different	different	ADJ
admet-686	305	47	laboratories	laboratory	NOUN
admet-686	305	48	[	[	X
admet-686	305	49	25	25	NUM
admet-686	305	50	]	]	PUNCT
admet-686	305	51	.	.	PUNCT
admet-686	306	1	how	how	SCONJ
admet-686	306	2	does	do	AUX
admet-686	306	3	such	such	DET
admet-686	306	4	an	an	DET
admet-686	306	5	impression	impression	NOUN
admet-686	306	6	of	of	ADP
admet-686	306	7	poor	poor	ADJ
admet-686	306	8	reproducibility	reproducibility	NOUN
admet-686	306	9	in	in	ADP
admet-686	306	10	solubility	solubility	NOUN
admet-686	306	11	measurement	measurement	NOUN
admet-686	306	12	arise	arise	VERB
admet-686	306	13	?	?	PUNCT
admet-686	307	1	as	as	SCONJ
admet-686	307	2	mentioned	mention	VERB
admet-686	307	3	earlier	early	ADV
admet-686	307	4	,	,	PUNCT
admet-686	307	5	it	it	PRON
admet-686	307	6	is	be	AUX
admet-686	307	7	not	not	PART
admet-686	307	8	uncommon	uncommon	ADJ
admet-686	307	9	to	to	PART
admet-686	307	10	assume	assume	VERB
admet-686	307	11	that	that	SCONJ
admet-686	307	12	the	the	DET
admet-686	307	13	solubility	solubility	NOUN
admet-686	307	14	2	2	NUM
admet-686	307	15	ph	ph	NOUN
admet-686	307	16	units	unit	NOUN
admet-686	307	17	below	below	ADP
admet-686	307	18	the	the	DET
admet-686	307	19	pka	pka	PROPN
admet-686	307	20	(	(	PUNCT
admet-686	307	21	for	for	ADP
admet-686	307	22	acids	acid	NOUN
admet-686	307	23	)	)	PUNCT
admet-686	307	24	or	or	CCONJ
admet-686	307	25	above	above	ADP
admet-686	307	26	the	the	DET
admet-686	307	27	pka	pka	NOUN
admet-686	307	28	(	(	PUNCT
admet-686	307	29	for	for	ADP
admet-686	307	30	bases	basis	NOUN
admet-686	307	31	)	)	PUNCT
admet-686	307	32	can	can	AUX
admet-686	307	33	be	be	AUX
admet-686	307	34	equated	equate	VERB
admet-686	307	35	with	with	ADP
admet-686	307	36	the	the	DET
admet-686	307	37	intrinsic	intrinsic	ADJ
admet-686	307	38	solubility	solubility	NOUN
admet-686	307	39	.	.	PUNCT
admet-686	308	1	clearly	clearly	ADV
admet-686	308	2	,	,	PUNCT
admet-686	308	3	such	such	DET
admet-686	308	4	an	an	DET
admet-686	308	5	approximation	approximation	NOUN
admet-686	308	6	would	would	AUX
admet-686	308	7	not	not	PART
admet-686	308	8	be	be	AUX
admet-686	308	9	accurate	accurate	ADJ
admet-686	308	10	in	in	ADP
admet-686	308	11	cases	case	NOUN
admet-686	308	12	of	of	ADP
admet-686	308	13	the	the	DET
admet-686	308	14	distortions	distortion	NOUN
admet-686	308	15	found	find	VERB
admet-686	308	16	in	in	ADP
admet-686	308	17	figures	figure	NOUN
admet-686	308	18	9f	9f	NUM
admet-686	308	19	-	-	SYM
admet-686	308	20	o	o	X
admet-686	308	21	(	(	PUNCT
admet-686	308	22	and	and	CCONJ
admet-686	308	23	those	those	PRON
admet-686	308	24	in	in	ADP
admet-686	308	25	fig	fig	NOUN
admet-686	308	26	.	.	PUNCT
admet-686	309	1	1a	1a	X
admet-686	309	2	,	,	PUNCT
admet-686	309	3	d	d	NOUN
admet-686	309	4	)	)	PUNCT
admet-686	309	5	.	.	PUNCT
admet-686	310	1	the	the	DET
admet-686	310	2	consequences	consequence	NOUN
admet-686	310	3	of	of	ADP
admet-686	310	4	the	the	DET
admet-686	310	5	above	above	ADJ
admet-686	310	6	approximation	approximation	NOUN
admet-686	310	7	can	can	AUX
admet-686	310	8	be	be	AUX
admet-686	310	9	illustrated	illustrate	VERB
admet-686	310	10	by	by	ADP
admet-686	310	11	selecting	select	VERB
admet-686	310	12	the	the	DET
admet-686	310	13	lowest	low	ADJ
admet-686	310	14	solubility	solubility	NOUN
admet-686	310	15	in	in	ADP
admet-686	310	16	each	each	PRON
admet-686	310	17	of	of	ADP
admet-686	310	18	the	the	DET
admet-686	310	19	17	17	NUM
admet-686	310	20	cases	case	NOUN
admet-686	310	21	and	and	CCONJ
admet-686	310	22	calculating	calculate	VERB
admet-686	310	23	the	the	DET
admet-686	310	24	average	average	NOUN
admet-686	310	25	:	:	PUNCT
admet-686	310	26	log	log	NOUN
admet-686	310	27	s0	s0	PROPN
admet-686	310	28	25	25	NUM
admet-686	310	29	(	(	PUNCT
admet-686	310	30	approx	approx	PROPN
admet-686	310	31	.	.	PUNCT
admet-686	310	32	)	)	PUNCT
admet-686	311	1	=	=	PRON
admet-686	311	2	-5.01	-5.01	DET
admet-686	311	3	±0.59	±0.59	PROPN
admet-686	311	4	(	(	PUNCT
admet-686	311	5	6.5	6.5	NUM
admet-686	311	6	±	±	NUM
admet-686	311	7	8.5	8.5	NUM
admet-686	311	8	μg	μg	NOUN
admet-686	311	9	/	/	SYM
admet-686	311	10	ml	ml	NOUN
admet-686	311	11	)	)	PUNCT
admet-686	311	12	.	.	PUNCT
admet-686	312	1	the	the	DET
admet-686	312	2	increased	increase	VERB
admet-686	312	3	apparent	apparent	ADJ
admet-686	312	4	standard	standard	ADJ
admet-686	312	5	deviation	deviation	NOUN
admet-686	312	6	,	,	PUNCT
admet-686	312	7	0.59	0.59	NUM
admet-686	312	8	,	,	PUNCT
admet-686	312	9	seems	seem	VERB
admet-686	312	10	to	to	PART
admet-686	312	11	be	be	AUX
admet-686	312	12	consistent	consistent	ADJ
admet-686	312	13	with	with	ADP
admet-686	312	14	the	the	DET
admet-686	312	15	~0.7	~0.7	NUM
admet-686	312	16	value	value	NOUN
admet-686	312	17	.	.	PUNCT
admet-686	313	1	prediction	prediction	NOUN
admet-686	313	2	of	of	ADP
admet-686	313	3	intrinsic	intrinsic	ADJ
admet-686	313	4	solubility	solubility	NOUN
admet-686	313	5	many	many	ADJ
admet-686	313	6	computational	computational	ADJ
admet-686	313	7	methods	method	NOUN
admet-686	313	8	for	for	ADP
admet-686	313	9	predicting	predict	VERB
admet-686	313	10	solubility	solubility	NOUN
admet-686	313	11	have	have	AUX
admet-686	313	12	been	be	AUX
admet-686	313	13	described	describe	VERB
admet-686	313	14	.	.	PUNCT
admet-686	314	1	these	these	PRON
admet-686	314	2	serve	serve	VERB
admet-686	314	3	the	the	DET
admet-686	314	4	important	important	ADJ
admet-686	314	5	need	need	NOUN
admet-686	314	6	to	to	PART
admet-686	314	7	predict	predict	VERB
admet-686	314	8	solubility	solubility	NOUN
admet-686	314	9	risks	risk	NOUN
admet-686	314	10	during	during	ADP
admet-686	314	11	structural	structural	ADJ
admet-686	314	12	design	design	NOUN
admet-686	314	13	in	in	ADP
admet-686	314	14	the	the	DET
admet-686	314	15	early	early	ADJ
admet-686	314	16	stages	stage	NOUN
admet-686	314	17	of	of	ADP
admet-686	314	18	drug	drug	NOUN
admet-686	314	19	discovery	discovery	NOUN
admet-686	314	20	.	.	PUNCT
admet-686	315	1	the	the	DET
admet-686	315	2	earlier	early	ADJ
admet-686	315	3	methods	method	NOUN
admet-686	315	4	used	use	VERB
admet-686	315	5	relatively	relatively	ADV
admet-686	315	6	small	small	ADJ
admet-686	315	7	training	training	NOUN
admet-686	315	8	sets	set	NOUN
admet-686	315	9	(	(	PUNCT
admet-686	315	10	<	<	X
admet-686	315	11	1000	1000	NUM
admet-686	315	12	compounds	compound	NOUN
admet-686	315	13	)	)	PUNCT
admet-686	315	14	,	,	PUNCT
admet-686	315	15	consisting	consist	VERB
admet-686	315	16	of	of	ADP
admet-686	315	17	molecules	molecule	NOUN
admet-686	315	18	(	(	PUNCT
admet-686	315	19	including	include	VERB
admet-686	315	20	liquids	liquid	NOUN
admet-686	315	21	and	and	CCONJ
admet-686	315	22	gases	gas	NOUN
admet-686	315	23	)	)	PUNCT
admet-686	315	24	such	such	ADJ
admet-686	315	25	as	as	ADP
admet-686	315	26	alcohols	alcohol	NOUN
admet-686	315	27	,	,	PUNCT
admet-686	315	28	pesticides	pesticide	NOUN
admet-686	315	29	,	,	PUNCT
admet-686	315	30	and	and	CCONJ
admet-686	315	31	herbicides	herbicide	NOUN
admet-686	315	32	.	.	PUNCT
admet-686	316	1	this	this	PRON
admet-686	316	2	limited	limit	VERB
admet-686	316	3	the	the	DET
admet-686	316	4	accuracy	accuracy	NOUN
admet-686	316	5	of	of	ADP
admet-686	316	6	the	the	DET
admet-686	316	7	prediction	prediction	NOUN
admet-686	316	8	of	of	ADP
admet-686	316	9	the	the	DET
admet-686	316	10	solubility	solubility	NOUN
admet-686	316	11	of	of	ADP
admet-686	316	12	drug	drug	NOUN
admet-686	316	13	solids	solid	NOUN
admet-686	316	14	.	.	PUNCT
admet-686	317	1	as	as	SCONJ
admet-686	317	2	more	more	ADJ
admet-686	317	3	drug	drug	NOUN
admet-686	317	4	data	datum	NOUN
admet-686	317	5	became	become	VERB
admet-686	317	6	available	available	ADJ
admet-686	317	7	for	for	ADP
admet-686	317	8	training	train	VERB
admet-686	317	9	the	the	DET
admet-686	317	10	prediction	prediction	NOUN
admet-686	317	11	models	model	NOUN
admet-686	317	12	,	,	PUNCT
admet-686	317	13	methods	method	NOUN
admet-686	317	14	improved	improve	VERB
admet-686	317	15	.	.	PUNCT
admet-686	318	1	the	the	DET
admet-686	318	2	‘	'	PUNCT
admet-686	318	3	solubility	solubility	NOUN
admet-686	318	4	challenge	challenge	NOUN
admet-686	318	5	’	'	PUNCT
admet-686	318	6	posed	pose	VERB
admet-686	318	7	by	by	ADP
admet-686	318	8	llinàs	llinà	NOUN
admet-686	318	9	et	et	PROPN
admet-686	318	10	al	al	PROPN
admet-686	318	11	.	.	PUNCT
admet-686	319	1	[	[	X
admet-686	319	2	65,66	65,66	NOUN
admet-686	319	3	]	]	X
admet-686	319	4	spurred	spur	VERB
admet-686	319	5	fresh	fresh	ADJ
admet-686	319	6	discussion	discussion	NOUN
admet-686	319	7	about	about	ADP
admet-686	319	8	prediction	prediction	NOUN
admet-686	319	9	efficacy	efficacy	NOUN
admet-686	319	10	and	and	CCONJ
admet-686	319	11	the	the	DET
admet-686	319	12	quality	quality	NOUN
admet-686	319	13	of	of	ADP
admet-686	319	14	available	available	ADJ
admet-686	319	15	data	datum	NOUN
admet-686	319	16	.	.	PUNCT
admet-686	320	1	the	the	DET
admet-686	320	2	meta	meta	ADJ
admet-686	320	3	-	-	PUNCT
admet-686	320	4	analysis	analysis	NOUN
admet-686	320	5	described	describe	VERB
admet-686	320	6	in	in	ADP
admet-686	320	7	the	the	DET
admet-686	320	8	preceding	precede	VERB
admet-686	320	9	section	section	NOUN
admet-686	320	10	examined	examine	VERB
admet-686	320	11	factors	factor	NOUN
admet-686	320	12	related	relate	VERB
admet-686	320	13	to	to	ADP
admet-686	320	14	data	datum	NOUN
admet-686	320	15	quality	quality	NOUN
admet-686	320	16	[	[	X
admet-686	320	17	50	50	NUM
admet-686	320	18	]	]	PUNCT
admet-686	320	19	.	.	PUNCT
admet-686	321	1	the	the	DET
admet-686	321	2	study	study	NOUN
admet-686	321	3	suggested	suggest	VERB
admet-686	321	4	two	two	NUM
admet-686	321	5	ways	way	NOUN
admet-686	321	6	to	to	PART
admet-686	321	7	improve	improve	VERB
admet-686	321	8	quality	quality	NOUN
admet-686	321	9	of	of	ADP
admet-686	321	10	legacy	legacy	NOUN
admet-686	321	11	measurement	measurement	NOUN
admet-686	321	12	of	of	ADP
admet-686	321	13	equilibrium	equilibrium	NOUN
admet-686	321	14	solubility	solubility	NOUN
admet-686	321	15	,	,	PUNCT
admet-686	321	16	as	as	SCONJ
admet-686	321	17	discussed	discuss	VERB
admet-686	321	18	above	above	ADV
admet-686	321	19	.	.	PUNCT
admet-686	322	1	methods	method	NOUN
admet-686	322	2	based	base	VERB
admet-686	322	3	on	on	ADP
admet-686	322	4	shake	shake	NOUN
admet-686	322	5	-	-	PUNCT
admet-686	322	6	flask	flask	NOUN
admet-686	322	7	measurement	measurement	NOUN
admet-686	322	8	as	as	ADP
admet-686	322	9	a	a	DET
admet-686	322	10	function	function	NOUN
admet-686	322	11	of	of	ADP
admet-686	322	12	ph	ph	PROPN
admet-686	322	13	(	(	PUNCT
admet-686	322	14	‘	'	PUNCT
admet-686	322	15	gold	gold	ADJ
admet-686	322	16	standard	standard	NOUN
admet-686	322	17	’	'	PUNCT
admet-686	322	18	)	)	PUNCT
admet-686	322	19	,	,	PUNCT
admet-686	322	20	and	and	CCONJ
admet-686	322	21	two	two	NUM
admet-686	322	22	potentiometric	potentiometric	ADJ
admet-686	322	23	methods	method	NOUN
admet-686	322	24	(	(	PUNCT
admet-686	322	25	psol	psol	NOUN
admet-686	322	26	&	&	CCONJ
admet-686	322	27	cheqsol	cheqsol	PROPN
admet-686	322	28	)	)	PUNCT
admet-686	322	29	can	can	AUX
admet-686	322	30	be	be	AUX
admet-686	322	31	recommended	recommend	VERB
admet-686	322	32	[	[	PUNCT
admet-686	322	33	4	4	NUM
admet-686	322	34	]	]	PUNCT
admet-686	322	35	.	.	PUNCT
admet-686	323	1	predictions	prediction	NOUN
admet-686	323	2	of	of	ADP
admet-686	323	3	solubility	solubility	NOUN
admet-686	323	4	in	in	ADP
admet-686	323	5	simulated	simulate	VERB
admet-686	323	6	and	and	CCONJ
admet-686	323	7	aspirated	aspirate	VERB
admet-686	323	8	intestinal	intestinal	ADJ
admet-686	323	9	fluids	fluid	NOUN
admet-686	323	10	are	be	AUX
admet-686	323	11	exciting	exciting	ADJ
admet-686	323	12	new	new	ADJ
admet-686	323	13	topics	topic	NOUN
admet-686	323	14	in	in	ADP
admet-686	323	15	current	current	ADJ
admet-686	323	16	research	research	NOUN
admet-686	323	17	[	[	X
admet-686	323	18	67	67	NUM
admet-686	323	19	]	]	PUNCT
admet-686	323	20	.	.	PUNCT
admet-686	324	1	summary	summary	NOUN
admet-686	324	2	and	and	CCONJ
admet-686	324	3	conclusions	conclusion	NOUN
admet-686	324	4	this	this	DET
admet-686	324	5	review	review	NOUN
admet-686	324	6	,	,	PUNCT
admet-686	324	7	albeit	albeit	SCONJ
admet-686	324	8	brief	brief	ADJ
admet-686	324	9	,	,	PUNCT
admet-686	324	10	points	point	NOUN
admet-686	324	11	towards	towards	ADP
admet-686	324	12	the	the	DET
admet-686	324	13	complexity	complexity	NOUN
admet-686	324	14	in	in	ADP
admet-686	324	15	understanding	understanding	NOUN
admet-686	324	16	and	and	CCONJ
admet-686	324	17	predicting	predict	VERB
admet-686	324	18	solubilityrelated	solubilityrelate	VERB
admet-686	324	19	processes	process	NOUN
admet-686	324	20	.	.	PUNCT
admet-686	325	1	these	these	PRON
admet-686	325	2	include	include	VERB
admet-686	325	3	dissolution	dissolution	NOUN
admet-686	325	4	,	,	PUNCT
admet-686	325	5	solubilization	solubilization	NOUN
admet-686	325	6	/	/	SYM
admet-686	325	7	aggregation	aggregation	NOUN
admet-686	325	8	,	,	PUNCT
admet-686	325	9	ph-	ph-	NUM
admet-686	325	10	,	,	PUNCT
admet-686	325	11	counterionand	counterionand	NOUN
admet-686	325	12	buffer	buffer	NOUN
admet-686	325	13	strength	strength	NOUN
admet-686	325	14	effects	effect	NOUN
admet-686	325	15	on	on	ADP
admet-686	325	16	solubility	solubility	NOUN
admet-686	325	17	,	,	PUNCT
admet-686	325	18	and	and	CCONJ
admet-686	325	19	the	the	DET
admet-686	325	20	impact	impact	NOUN
admet-686	325	21	of	of	ADP
admet-686	325	22	salt	salt	NOUN
admet-686	325	23	and	and	CCONJ
admet-686	325	24	cocrystal	cocrystal	ADJ
admet-686	325	25	formation	formation	NOUN
admet-686	325	26	on	on	ADP
admet-686	325	27	dissolution	dissolution	NOUN
admet-686	325	28	,	,	PUNCT
admet-686	325	29	solubility	solubility	NOUN
admet-686	325	30	and	and	CCONJ
admet-686	325	31	supersaturation	supersaturation	NOUN
admet-686	325	32	.	.	PUNCT
admet-686	326	1	the	the	DET
admet-686	326	2	debate	debate	NOUN
admet-686	326	3	around	around	ADP
admet-686	326	4	how	how	SCONJ
admet-686	326	5	consistent	consistent	ADJ
admet-686	326	6	data	datum	NOUN
admet-686	326	7	we	we	PRON
admet-686	326	8	can	can	AUX
admet-686	326	9	achieve	achieve	VERB
admet-686	326	10	from	from	ADP
admet-686	326	11	solubility	solubility	NOUN
admet-686	326	12	assays	assay	NOUN
admet-686	326	13	and	and	CCONJ
admet-686	326	14	to	to	ADP
admet-686	326	15	what	what	DET
admet-686	326	16	extent	extent	NOUN
admet-686	326	17	the	the	DET
admet-686	326	18	data	datum	NOUN
admet-686	326	19	can	can	AUX
admet-686	326	20	be	be	AUX
admet-686	326	21	used	use	VERB
admet-686	326	22	to	to	PART
admet-686	326	23	model	model	VERB
admet-686	326	24	and	and	CCONJ
admet-686	326	25	predict	predict	VERB
admet-686	326	26	,	,	PUNCT
admet-686	326	27	e.g.	e.g.	ADV
admet-686	326	28	,	,	PUNCT
admet-686	326	29	ph	ph	NOUN
admet-686	326	30	-	-	NOUN
admet-686	326	31	dependence	dependence	NOUN
admet-686	326	32	or	or	CCONJ
admet-686	326	33	solubilization	solubilization	NOUN
admet-686	326	34	tendencies	tendency	NOUN
admet-686	326	35	in	in	ADP
admet-686	326	36	different	different	ADJ
admet-686	326	37	solvents	solvent	NOUN
admet-686	326	38	will	will	AUX
admet-686	326	39	continue	continue	VERB
admet-686	326	40	.	.	PUNCT
admet-686	327	1	a	a	DET
admet-686	327	2	platform	platform	NOUN
admet-686	327	3	for	for	ADP
admet-686	327	4	such	such	DET
admet-686	327	5	a	a	DET
admet-686	327	6	vibrant	vibrant	ADJ
admet-686	327	7	discussion	discussion	NOUN
admet-686	327	8	which	which	PRON
admet-686	327	9	will	will	AUX
admet-686	327	10	spur	spur	VERB
admet-686	327	11	new	new	ADJ
admet-686	327	12	ideas	idea	NOUN
admet-686	327	13	is	be	AUX
admet-686	327	14	the	the	DET
admet-686	327	15	upcoming	upcoming	ADJ
admet-686	327	16	iapc-8	iapc-8	NUM
admet-686	327	17	meeting	meeting	NOUN
admet-686	327	18	where	where	SCONJ
admet-686	327	19	these	these	DET
admet-686	327	20	topics	topic	NOUN
admet-686	327	21	will	will	AUX
admet-686	327	22	be	be	AUX
admet-686	327	23	further	far	ADV
admet-686	327	24	explored	explore	VERB
admet-686	327	25	.	.	PUNCT
admet-686	328	1	conflict	conflict	NOUN
admet-686	328	2	of	of	ADP
admet-686	328	3	interest	interest	NOUN
admet-686	328	4	:	:	PUNCT
admet-686	328	5	none	none	NOUN
admet-686	328	6	.	.	PUNCT
admet-686	329	1	bergström	bergström	NOUN
admet-686	329	2	and	and	CCONJ
admet-686	329	3	avdeef	avdeef	PROPN
admet-686	329	4	admet	admet	PROPN
admet-686	329	5	&	&	CCONJ
admet-686	329	6	dmpk	dmpk	PROPN
admet-686	329	7	7(2	7(2	NUM
admet-686	329	8	)	)	PUNCT
admet-686	329	9	(	(	PUNCT
admet-686	329	10	2019	2019	NUM
admet-686	329	11	)	)	PUNCT
admet-686	329	12	88	88	NUM
admet-686	329	13	-	-	SYM
admet-686	329	14	105	105	NUM
admet-686	329	15	102	102	NUM
admet-686	329	16	references	reference	NOUN
admet-686	329	17	[	[	X
admet-686	329	18	1	1	NUM
admet-686	329	19	]	]	PUNCT
admet-686	329	20	d.	d.	PROPN
admet-686	329	21	hörter	hörter	PROPN
admet-686	329	22	,	,	PUNCT
admet-686	329	23	j.b	j.b	PROPN
admet-686	329	24	.	.	PROPN
admet-686	329	25	dressman	dressman	PROPN
admet-686	329	26	.	.	PUNCT
admet-686	330	1	influence	influence	NOUN
admet-686	330	2	of	of	ADP
admet-686	330	3	physicochemical	physicochemical	ADJ
admet-686	330	4	properties	property	NOUN
admet-686	330	5	on	on	ADP
admet-686	330	6	dissolution	dissolution	NOUN
admet-686	330	7	of	of	ADP
admet-686	330	8	drugs	drug	NOUN
admet-686	330	9	in	in	ADP
admet-686	330	10	the	the	DET
admet-686	330	11	gastrointestinal	gastrointestinal	ADJ
admet-686	330	12	tract	tract	NOUN
admet-686	330	13	.	.	PUNCT
admet-686	331	1	adv	adv	PROPN
admet-686	331	2	.	.	PUNCT
admet-686	331	3	drug	drug	PROPN
admet-686	331	4	deliv	deliv	PROPN
admet-686	331	5	.	.	PUNCT
admet-686	332	1	rev	rev	PROPN
admet-686	332	2	.	.	PROPN
admet-686	332	3	25	25	NUM
admet-686	332	4	(	(	PUNCT
admet-686	332	5	1997	1997	NUM
admet-686	332	6	)	)	PUNCT
admet-686	332	7	3	3	NUM
admet-686	332	8	-	-	SYM
admet-686	332	9	14	14	NUM
admet-686	332	10	.	.	PUNCT
admet-686	333	1	[	[	X
admet-686	333	2	2	2	X
admet-686	333	3	]	]	X
admet-686	333	4	n.g	n.g	PROPN
admet-686	333	5	.	.	PROPN
admet-686	333	6	solankin	solankin	PROPN
admet-686	333	7	,	,	PUNCT
admet-686	333	8	k.	k.	PROPN
admet-686	333	9	lam	lam	PROPN
admet-686	333	10	,	,	PUNCT
admet-686	333	11	m.	m.	PROPN
admet-686	333	12	tahsin	tahsin	PROPN
admet-686	333	13	,	,	PUNCT
admet-686	333	14	s.g	s.g	PROPN
admet-686	333	15	.	.	PROPN
admet-686	333	16	gumaste	gumaste	PROPN
admet-686	333	17	,	,	PUNCT
admet-686	333	18	a.v	a.v	PROPN
admet-686	333	19	.	.	PROPN
admet-686	333	20	shah	shah	PROPN
admet-686	333	21	,	,	PUNCT
admet-686	333	22	a.t.m	a.t.m	PROPN
admet-686	333	23	.	.	PUNCT
admet-686	333	24	serajuddin	serajuddin	PROPN
admet-686	333	25	.	.	PUNCT
admet-686	334	1	effects	effect	NOUN
admet-686	334	2	of	of	ADP
admet-686	334	3	surfactants	surfactant	NOUN
admet-686	334	4	on	on	ADP
admet-686	334	5	itraconazole	itraconazole	ADJ
admet-686	334	6	-	-	PUNCT
admet-686	334	7	hpmcas	hpmca	NOUN
admet-686	334	8	solid	solid	ADJ
admet-686	334	9	dispersion	dispersion	NOUN
admet-686	334	10	prepared	prepare	VERB
admet-686	334	11	by	by	ADP
admet-686	334	12	hot	hot	ADJ
admet-686	334	13	melt	melt	NOUN
admet-686	334	14	extrusion	extrusion	NOUN
admet-686	334	15	.	.	PUNCT
admet-686	335	1	i	i	PRON
admet-686	335	2	:	:	PUNCT
admet-686	335	3	miscibility	miscibility	NOUN
admet-686	335	4	and	and	CCONJ
admet-686	335	5	drug	drug	NOUN
admet-686	335	6	release	release	NOUN
admet-686	335	7	.	.	PUNCT
admet-686	336	1	j.	j.	PROPN
admet-686	336	2	pharm	pharm	PROPN
admet-686	336	3	.	.	PUNCT
admet-686	337	1	sci	sci	PROPN
admet-686	337	2	.	.	PUNCT
admet-686	338	1	(	(	PUNCT
admet-686	338	2	2018	2018	NUM
admet-686	338	3	)	)	PUNCT
admet-686	338	4	in	in	ADP
admet-686	338	5	press	press	NOUN
admet-686	338	6	.	.	PUNCT
admet-686	339	1	doi	doi	NOUN
admet-686	339	2	:	:	PUNCT
admet-686	339	3	10.1016	10.1016	NUM
admet-686	339	4	/	/	SYM
admet-686	339	5	j.xphs.2018.10.058	j.xphs.2018.10.058	PROPN
admet-686	339	6	.	.	PUNCT
admet-686	340	1	[	[	X
admet-686	340	2	3	3	X
admet-686	340	3	]	]	PUNCT
admet-686	340	4	c.a.s	c.a.s	PROPN
admet-686	340	5	.	.	PUNCT
admet-686	340	6	bergström	bergström	PROPN
admet-686	340	7	,	,	PUNCT
admet-686	341	1	r.	r.	PROPN
admet-686	341	2	holm	holm	PROPN
admet-686	341	3	,	,	PUNCT
admet-686	341	4	s.a	s.a	PROPN
admet-686	341	5	.	.	PROPN
admet-686	341	6	jørgensen	jørgensen	PROPN
admet-686	341	7	,	,	PUNCT
admet-686	341	8	s.b.e	s.b.e	NOUN
admet-686	341	9	.	.	PUNCT
admet-686	341	10	andersson	andersson	PROPN
admet-686	341	11	,	,	PUNCT
admet-686	341	12	p.	p.	PROPN
admet-686	341	13	artursson	artursson	PROPN
admet-686	341	14	,	,	PUNCT
admet-686	341	15	s.	s.	PROPN
admet-686	341	16	beato	beato	PROPN
admet-686	341	17	,	,	PUNCT
admet-686	341	18	a.	a.	PROPN
admet-686	341	19	borde	borde	PROPN
admet-686	341	20	,	,	PUNCT
admet-686	341	21	k.	k.	PROPN
admet-686	341	22	box	box	PROPN
admet-686	341	23	,	,	PUNCT
admet-686	341	24	m.	m.	NOUN
admet-686	341	25	brewster	brewster	NOUN
admet-686	341	26	,	,	PUNCT
admet-686	341	27	j.	j.	PROPN
admet-686	341	28	dressman	dressman	PROPN
admet-686	341	29	,	,	PUNCT
admet-686	341	30	k.-i	k.-i	PROPN
admet-686	341	31	.	.	PUNCT
admet-686	342	1	feng	feng	PROPN
admet-686	342	2	,	,	PUNCT
admet-686	342	3	g.	g.	PROPN
admet-686	342	4	halbert	halbert	PROPN
admet-686	342	5	,	,	PUNCT
admet-686	342	6	e.	e.	PROPN
admet-686	342	7	kostewicz	kostewicz	PROPN
admet-686	342	8	,	,	PUNCT
admet-686	342	9	m.	m.	NOUN
admet-686	342	10	mcallister	mcallister	PROPN
admet-686	342	11	,	,	PUNCT
admet-686	342	12	u.	u.	PROPN
admet-686	342	13	muenster	muenster	PROPN
admet-686	342	14	,	,	PUNCT
admet-686	342	15	j.	j.	PROPN
admet-686	342	16	thinnes	thinnes	PROPN
admet-686	342	17	,	,	PUNCT
admet-686	342	18	r.	r.	PROPN
admet-686	342	19	taylor	taylor	PROPN
admet-686	342	20	,	,	PUNCT
admet-686	342	21	a.	a.	NOUN
admet-686	342	22	mullertz	mullertz	NOUN
admet-686	342	23	.	.	PUNCT
admet-686	343	1	early	early	ADJ
admet-686	343	2	pharmaceutical	pharmaceutical	NOUN
admet-686	343	3	profiling	profiling	NOUN
admet-686	343	4	to	to	PART
admet-686	343	5	predict	predict	VERB
admet-686	343	6	oral	oral	ADJ
admet-686	343	7	drug	drug	NOUN
admet-686	343	8	absorption	absorption	NOUN
admet-686	343	9	:	:	PUNCT
admet-686	343	10	current	current	ADJ
admet-686	343	11	status	status	NOUN
admet-686	343	12	and	and	CCONJ
admet-686	343	13	unmet	unmet	NOUN
admet-686	343	14	needs	need	NOUN
admet-686	343	15	.	.	PUNCT
admet-686	344	1	eur	eur	PROPN
admet-686	344	2	.	.	PUNCT
admet-686	345	1	j.	j.	PROPN
admet-686	345	2	pharm	pharm	PROPN
admet-686	345	3	.	.	PUNCT
admet-686	346	1	sci	sci	PROPN
admet-686	346	2	.	.	PROPN
admet-686	347	1	57	57	NUM
admet-686	347	2	(	(	PUNCT
admet-686	347	3	2014	2014	NUM
admet-686	347	4	)	)	PUNCT
admet-686	347	5	173	173	NUM
admet-686	347	6	-	-	SYM
admet-686	347	7	199	199	NUM
admet-686	347	8	.	.	PUNCT
admet-686	348	1	[	[	X
admet-686	348	2	4	4	NUM
admet-686	348	3	]	]	PUNCT
admet-686	348	4	a.	a.	NOUN
admet-686	348	5	avdeef	avdeef	PROPN
admet-686	348	6	,	,	PUNCT
admet-686	348	7	e.	e.	PROPN
admet-686	348	8	fuguet	fuguet	PROPN
admet-686	348	9	,	,	PUNCT
admet-686	348	10	a.	a.	PROPN
admet-686	348	11	llinàs	llinàs	PROPN
admet-686	348	12	,	,	PUNCT
admet-686	348	13	c.	c.	PROPN
admet-686	348	14	ràfols	ràfols	PROPN
admet-686	348	15	,	,	PUNCT
admet-686	348	16	e.	e.	PROPN
admet-686	348	17	bosch	bosch	PROPN
admet-686	348	18	,	,	PUNCT
admet-686	348	19	g.	g.	PROPN
admet-686	348	20	völgyi	völgyi	PROPN
admet-686	348	21	,	,	PUNCT
admet-686	348	22	t.	t.	NOUN
admet-686	348	23	verbić	verbić	PROPN
admet-686	348	24	,	,	PUNCT
admet-686	348	25	e.	e.	PROPN
admet-686	348	26	boldyreva	boldyreva	PROPN
admet-686	348	27	,	,	PUNCT
admet-686	348	28	k.	k.	PROPN
admet-686	348	29	takács	takács	PROPN
admet-686	348	30	-	-	PUNCT
admet-686	348	31	novák	novák	PROPN
admet-686	348	32	.	.	PUNCT
admet-686	348	33	equilibrium	equilibrium	NOUN
admet-686	348	34	solubility	solubility	NOUN
admet-686	348	35	measurement	measurement	NOUN
admet-686	348	36	of	of	ADP
admet-686	348	37	ionizable	ionizable	ADJ
admet-686	348	38	drugs	drug	NOUN
admet-686	348	39	–	–	PUNCT
admet-686	348	40	consensus	consensus	NOUN
admet-686	348	41	recommendations	recommendation	NOUN
admet-686	348	42	for	for	ADP
admet-686	348	43	improving	improve	VERB
admet-686	348	44	data	datum	NOUN
admet-686	348	45	quality	quality	NOUN
admet-686	348	46	.	.	PUNCT
admet-686	349	1	admet	admet	PROPN
admet-686	349	2	&	&	CCONJ
admet-686	349	3	dmpk	dmpk	PROPN
admet-686	349	4	4	4	NUM
admet-686	349	5	(	(	PUNCT
admet-686	349	6	2016	2016	NUM
admet-686	349	7	)	)	PUNCT
admet-686	349	8	117	117	NUM
admet-686	349	9	-	-	SYM
admet-686	349	10	178	178	NUM
admet-686	349	11	.	.	PUNCT
admet-686	350	1	[	[	X
admet-686	350	2	5	5	NUM
admet-686	350	3	]	]	X
admet-686	350	4	c.a	c.a	PROPN
admet-686	350	5	.	.	PROPN
admet-686	350	6	lipinski	lipinski	PROPN
admet-686	350	7	,	,	PUNCT
admet-686	350	8	f.	f.	PROPN
admet-686	350	9	lombardo	lombardo	PROPN
admet-686	350	10	,	,	PUNCT
admet-686	350	11	b.w	b.w	PROPN
admet-686	350	12	.	.	PROPN
admet-686	350	13	dominy	dominy	PROPN
admet-686	350	14	,	,	PUNCT
admet-686	350	15	p.j	p.j	PROPN
admet-686	350	16	.	.	PROPN
admet-686	350	17	feeney	feeney	PROPN
admet-686	350	18	.	.	PUNCT
admet-686	351	1	experimental	experimental	ADJ
admet-686	351	2	and	and	CCONJ
admet-686	351	3	computational	computational	ADJ
admet-686	351	4	approaches	approach	NOUN
admet-686	351	5	to	to	PART
admet-686	351	6	estimate	estimate	VERB
admet-686	351	7	solubility	solubility	NOUN
admet-686	351	8	and	and	CCONJ
admet-686	351	9	permeability	permeability	NOUN
admet-686	351	10	in	in	ADP
admet-686	351	11	drug	drug	NOUN
admet-686	351	12	discovery	discovery	NOUN
admet-686	351	13	and	and	CCONJ
admet-686	351	14	development	development	NOUN
admet-686	351	15	settings	setting	NOUN
admet-686	351	16	.	.	PUNCT
admet-686	352	1	adv	adv	PROPN
admet-686	352	2	.	.	PUNCT
admet-686	352	3	drug	drug	PROPN
admet-686	352	4	delivery	delivery	PROPN
admet-686	352	5	rev	rev	VERB
admet-686	352	6	.	.	PROPN
admet-686	352	7	23	23	NUM
admet-686	352	8	(	(	PUNCT
admet-686	352	9	1997	1997	NUM
admet-686	352	10	)	)	PUNCT
admet-686	352	11	3	3	NUM
admet-686	352	12	-	-	SYM
admet-686	352	13	25	25	NUM
admet-686	352	14	.	.	PUNCT
admet-686	353	1	[	[	X
admet-686	353	2	6	6	NUM
admet-686	353	3	]	]	PUNCT
admet-686	353	4	c.	c.	PROPN
admet-686	353	5	saal	saal	PROPN
admet-686	353	6	,	,	PUNCT
admet-686	353	7	a.c	a.c	PROPN
admet-686	353	8	.	.	PROPN
admet-686	353	9	petereit	petereit	NOUN
admet-686	353	10	.	.	PUNCT
admet-686	354	1	optimizing	optimize	VERB
admet-686	354	2	solubility	solubility	NOUN
admet-686	354	3	:	:	PUNCT
admet-686	354	4	kinetic	kinetic	ADJ
admet-686	354	5	versus	versus	ADP
admet-686	354	6	thermodynamic	thermodynamic	ADJ
admet-686	354	7	solubility	solubility	NOUN
admet-686	354	8	temptations	temptation	NOUN
admet-686	354	9	and	and	CCONJ
admet-686	354	10	risks	risk	NOUN
admet-686	354	11	.	.	PUNCT
admet-686	355	1	eur	eur	PROPN
admet-686	355	2	.	.	PUNCT
admet-686	356	1	j.	j.	PROPN
admet-686	356	2	pharm	pharm	PROPN
admet-686	356	3	.	.	PUNCT
admet-686	357	1	sci	sci	PROPN
admet-686	357	2	.	.	PROPN
admet-686	358	1	47	47	NUM
admet-686	358	2	(	(	PUNCT
admet-686	358	3	2012	2012	NUM
admet-686	358	4	)	)	PUNCT
admet-686	358	5	589	589	NUM
admet-686	358	6	-	-	SYM
admet-686	358	7	595	595	NUM
admet-686	358	8	.	.	PUNCT
admet-686	359	1	[	[	X
admet-686	359	2	7	7	X
admet-686	359	3	]	]	X
admet-686	359	4	n.m	n.m	PROPN
admet-686	359	5	.	.	PROPN
admet-686	359	6	ahmad	ahmad	PROPN
admet-686	359	7	.	.	PUNCT
admet-686	360	1	solubility	solubility	NOUN
admet-686	360	2	-	-	PUNCT
admet-686	360	3	driven	drive	VERB
admet-686	360	4	lead	lead	NOUN
admet-686	360	5	optimization	optimization	NOUN
admet-686	360	6	:	:	PUNCT
admet-686	360	7	recent	recent	ADJ
admet-686	360	8	examples	example	NOUN
admet-686	360	9	and	and	CCONJ
admet-686	360	10	personal	personal	ADJ
admet-686	360	11	perspectives	perspective	NOUN
admet-686	360	12	.	.	PUNCT
admet-686	361	1	bioorg	bioorg	ADJ
admet-686	361	2	.	.	PUNCT
admet-686	362	1	med	med	PROPN
admet-686	362	2	.	.	PROPN
admet-686	362	3	chem	chem	PROPN
admet-686	362	4	.	.	PUNCT
admet-686	363	1	lett	lett	PROPN
admet-686	363	2	.	.	PUNCT
admet-686	364	1	26	26	NUM
admet-686	364	2	(	(	PUNCT
admet-686	364	3	2016	2016	NUM
admet-686	364	4	)	)	PUNCT
admet-686	364	5	2975	2975	NUM
admet-686	364	6	-	-	SYM
admet-686	364	7	2979	2979	NUM
admet-686	364	8	.	.	PUNCT
admet-686	365	1	[	[	X
admet-686	365	2	8	8	NUM
admet-686	365	3	]	]	X
admet-686	365	4	l.	l.	PROPN
admet-686	365	5	di	di	PROPN
admet-686	365	6	,	,	PUNCT
admet-686	365	7	p.v	p.v	PROPN
admet-686	365	8	.	.	PROPN
admet-686	365	9	fish	fish	NOUN
admet-686	365	10	,	,	PUNCT
admet-686	365	11	t.	t.	PROPN
admet-686	365	12	mano	mano	PROPN
admet-686	365	13	.	.	PUNCT
admet-686	366	1	bridging	bridging	NOUN
admet-686	366	2	solubility	solubility	NOUN
admet-686	366	3	between	between	ADP
admet-686	366	4	drug	drug	NOUN
admet-686	366	5	discovery	discovery	NOUN
admet-686	366	6	and	and	CCONJ
admet-686	366	7	development	development	NOUN
admet-686	366	8	.	.	PUNCT
admet-686	367	1	drug	drug	NOUN
admet-686	367	2	disc	disc	NOUN
admet-686	367	3	.	.	PUNCT
admet-686	368	1	today	today	NOUN
admet-686	368	2	17	17	NUM
admet-686	368	3	(	(	PUNCT
admet-686	368	4	2012	2012	NUM
admet-686	368	5	)	)	PUNCT
admet-686	368	6	486	486	NUM
admet-686	368	7	-	-	SYM
admet-686	368	8	495	495	NUM
admet-686	368	9	.	.	PUNCT
admet-686	369	1	[	[	X
admet-686	369	2	9	9	NUM
admet-686	369	3	]	]	X
admet-686	369	4	t.	t.	PROPN
admet-686	369	5	sou	sou	PROPN
admet-686	369	6	,	,	PUNCT
admet-686	369	7	c.a.s	c.a.	VERB
admet-686	369	8	.	.	PROPN
admet-686	369	9	bergström	bergström	PROPN
admet-686	369	10	.	.	PUNCT
admet-686	370	1	automated	automate	VERB
admet-686	370	2	assays	assay	NOUN
admet-686	370	3	for	for	ADP
admet-686	370	4	thermodynamic	thermodynamic	ADJ
admet-686	370	5	(	(	PUNCT
admet-686	370	6	equilibrium	equilibrium	NOUN
admet-686	370	7	)	)	PUNCT
admet-686	370	8	solubility	solubility	NOUN
admet-686	370	9	determination	determination	NOUN
admet-686	370	10	.	.	PUNCT
admet-686	371	1	drug	drug	NOUN
admet-686	371	2	discov	discov	NOUN
admet-686	371	3	.	.	PUNCT
admet-686	372	1	today	today	NOUN
admet-686	372	2	:	:	PUNCT
admet-686	372	3	technol	technol	ADJ
admet-686	372	4	.	.	NOUN
admet-686	372	5	2	2	NUM
admet-686	372	6	(	(	PUNCT
admet-686	372	7	2018	2018	NUM
admet-686	372	8	)	)	PUNCT
admet-686	372	9	11	11	NUM
admet-686	372	10	-	-	SYM
admet-686	372	11	19	19	NUM
admet-686	372	12	.	.	PUNCT
admet-686	373	1	[	[	X
admet-686	373	2	10	10	NUM
admet-686	373	3	]	]	X
admet-686	373	4	á	á	PROPN
admet-686	373	5	.	.	PUNCT
admet-686	373	6	könczöl	könczöl	PROPN
admet-686	373	7	,	,	PUNCT
admet-686	373	8	g.	g.	PROPN
admet-686	373	9	dargó	dargó	PROPN
admet-686	373	10	.	.	PUNCT
admet-686	374	1	brief	brief	ADJ
admet-686	374	2	overview	overview	NOUN
admet-686	374	3	of	of	ADP
admet-686	374	4	solubility	solubility	NOUN
admet-686	374	5	methods	method	NOUN
admet-686	374	6	:	:	PUNCT
admet-686	374	7	recent	recent	ADJ
admet-686	374	8	trends	trend	NOUN
admet-686	374	9	in	in	ADP
admet-686	374	10	equilibrium	equilibrium	NOUN
admet-686	374	11	solubility	solubility	NOUN
admet-686	374	12	measurement	measurement	NOUN
admet-686	374	13	and	and	CCONJ
admet-686	374	14	predictive	predictive	ADJ
admet-686	374	15	models	model	NOUN
admet-686	374	16	.	.	PUNCT
admet-686	375	1	drug	drug	NOUN
admet-686	375	2	discov	discov	NOUN
admet-686	375	3	.	.	PUNCT
admet-686	376	1	today	today	NOUN
admet-686	376	2	:	:	PUNCT
admet-686	376	3	technol	technol	ADJ
admet-686	376	4	.	.	PUNCT
admet-686	376	5	27	27	NUM
admet-686	376	6	(	(	PUNCT
admet-686	376	7	2018	2018	NUM
admet-686	376	8	)	)	PUNCT
admet-686	376	9	3	3	NUM
admet-686	376	10	-	-	SYM
admet-686	376	11	10	10	NUM
admet-686	376	12	.	.	PUNCT
admet-686	377	1	[	[	X
admet-686	377	2	11	11	NUM
admet-686	377	3	]	]	PUNCT
admet-686	377	4	c.a.s	c.a.s	X
admet-686	377	5	bergström	bergström	NOUN
admet-686	377	6	,	,	PUNCT
admet-686	377	7	w.n	w.n	PROPN
admet-686	377	8	.	.	PROPN
admet-686	377	9	charman	charman	PROPN
admet-686	377	10	,	,	PUNCT
admet-686	377	11	c.j.h	c.j.h	ADJ
admet-686	377	12	.	.	PUNCT
admet-686	377	13	porter	porter	NOUN
admet-686	377	14	.	.	PUNCT
admet-686	378	1	computational	computational	ADJ
admet-686	378	2	prediction	prediction	NOUN
admet-686	378	3	of	of	ADP
admet-686	378	4	formulation	formulation	NOUN
admet-686	378	5	strategies	strategy	NOUN
admet-686	378	6	for	for	ADP
admet-686	378	7	beyond	beyond	ADP
admet-686	378	8	-	-	PUNCT
admet-686	378	9	rule	rule	NOUN
admet-686	378	10	-	-	PUNCT
admet-686	378	11	of-5	of-5	NOUN
admet-686	378	12	compounds	compound	NOUN
admet-686	378	13	.	.	PUNCT
admet-686	379	1	adv	adv	PROPN
admet-686	379	2	.	.	PUNCT
admet-686	379	3	drug	drug	PROPN
admet-686	379	4	deliv	deliv	PROPN
admet-686	379	5	.	.	PUNCT
admet-686	380	1	rev	rev	PROPN
admet-686	380	2	.	.	PROPN
admet-686	381	1	101	101	NUM
admet-686	381	2	(	(	PUNCT
admet-686	381	3	2016	2016	NUM
admet-686	381	4	)	)	PUNCT
admet-686	381	5	6	6	NUM
admet-686	381	6	-	-	SYM
admet-686	381	7	21	21	NUM
admet-686	381	8	.	.	PUNCT
admet-686	382	1	[	[	X
admet-686	382	2	12	12	NUM
admet-686	382	3	]	]	X
admet-686	382	4	c.a	c.a	PROPN
admet-686	382	5	.	.	PROPN
admet-686	382	6	bergström	bergström	PROPN
admet-686	382	7	,	,	PUNCT
admet-686	382	8	c.m	c.m	PROPN
admet-686	382	9	.	.	PROPN
admet-686	382	10	wassvik	wassvik	PROPN
admet-686	382	11	,	,	PUNCT
admet-686	382	12	k.	k.	PROPN
admet-686	382	13	johansson	johansson	PROPN
admet-686	382	14	,	,	PUNCT
admet-686	382	15	i.	i.	PROPN
admet-686	382	16	hubatsch	hubatsch	PROPN
admet-686	382	17	.	.	PUNCT
admet-686	383	1	poorly	poorly	ADV
admet-686	383	2	soluble	soluble	ADJ
admet-686	383	3	marketed	market	VERB
admet-686	383	4	drugs	drug	NOUN
admet-686	383	5	display	display	NOUN
admet-686	383	6	solvation	solvation	NOUN
admet-686	383	7	limited	limited	PROPN
admet-686	383	8	solubility	solubility	PROPN
admet-686	383	9	.	.	PUNCT
admet-686	384	1	j.	j.	PROPN
admet-686	384	2	med	med	PROPN
admet-686	384	3	.	.	PROPN
admet-686	384	4	chem	chem	PROPN
admet-686	384	5	.	.	PUNCT
admet-686	385	1	50	50	NUM
admet-686	385	2	(	(	PUNCT
admet-686	385	3	2007	2007	NUM
admet-686	385	4	)	)	PUNCT
admet-686	385	5	5858	5858	NUM
admet-686	385	6	-	-	SYM
admet-686	385	7	5862	5862	NUM
admet-686	385	8	.	.	PUNCT
admet-686	386	1	[	[	X
admet-686	386	2	13	13	NUM
admet-686	386	3	]	]	X
admet-686	386	4	a.p	a.p	PROPN
admet-686	386	5	.	.	PROPN
admet-686	386	6	hill	hill	PROPN
admet-686	386	7	,	,	PUNCT
admet-686	386	8	r.j	r.j	PROPN
admet-686	386	9	.	.	PROPN
admet-686	386	10	young	young	PROPN
admet-686	386	11	.	.	PUNCT
admet-686	387	1	getting	get	VERB
admet-686	387	2	physical	physical	ADJ
admet-686	387	3	in	in	ADP
admet-686	387	4	drug	drug	NOUN
admet-686	387	5	discovery	discovery	NOUN
admet-686	387	6	:	:	PUNCT
admet-686	387	7	a	a	DET
admet-686	387	8	contemporary	contemporary	ADJ
admet-686	387	9	perspective	perspective	NOUN
admet-686	387	10	on	on	ADP
admet-686	387	11	solubility	solubility	NOUN
admet-686	387	12	and	and	CCONJ
admet-686	387	13	hydrophobicity	hydrophobicity	NOUN
admet-686	387	14	.	.	PUNCT
admet-686	388	1	drug	drug	NOUN
admet-686	388	2	disc	disc	NOUN
admet-686	388	3	.	.	PUNCT
admet-686	389	1	today	today	NOUN
admet-686	389	2	15	15	NUM
admet-686	389	3	(	(	PUNCT
admet-686	389	4	2010	2010	NUM
admet-686	389	5	)	)	PUNCT
admet-686	389	6	648	648	NUM
admet-686	389	7	-	-	SYM
admet-686	389	8	655	655	NUM
admet-686	389	9	.	.	PUNCT
admet-686	390	1	[	[	X
admet-686	390	2	14	14	NUM
admet-686	390	3	]	]	X
admet-686	390	4	d.	d.	PROPN
admet-686	390	5	riethorst	riethorst	PROPN
admet-686	390	6	,	,	PUNCT
admet-686	390	7	j.	j.	PROPN
admet-686	390	8	brouwers	brouwers	PROPN
admet-686	390	9	,	,	PUNCT
admet-686	390	10	j.	j.	PROPN
admet-686	390	11	motmans	motmans	PROPN
admet-686	390	12	,	,	PUNCT
admet-686	390	13	p.	p.	NOUN
admet-686	390	14	augustijns	augustijns	NOUN
admet-686	390	15	.	.	PUNCT
admet-686	391	1	human	human	ADJ
admet-686	391	2	intestinal	intestinal	ADJ
admet-686	391	3	fluid	fluid	NOUN
admet-686	391	4	factors	factor	NOUN
admet-686	391	5	affecting	affect	VERB
admet-686	391	6	intestinal	intestinal	ADJ
admet-686	391	7	drug	drug	NOUN
admet-686	391	8	permeation	permeation	NOUN
admet-686	391	9	in	in	ADP
admet-686	391	10	vitro	vitro	X
admet-686	391	11	.	.	PUNCT
admet-686	392	1	eur	eur	PROPN
admet-686	392	2	.	.	PUNCT
admet-686	393	1	j.	j.	PROPN
admet-686	393	2	pharm	pharm	PROPN
admet-686	393	3	.	.	PUNCT
admet-686	394	1	sci	sci	PROPN
admet-686	394	2	.	.	PROPN
admet-686	395	1	121	121	NUM
admet-686	395	2	(	(	PUNCT
admet-686	395	3	2018	2018	NUM
admet-686	395	4	)	)	PUNCT
admet-686	395	5	338	338	NUM
admet-686	395	6	-	-	SYM
admet-686	395	7	346	346	NUM
admet-686	395	8	.	.	PUNCT
admet-686	396	1	[	[	X
admet-686	396	2	15	15	NUM
admet-686	396	3	]	]	X
admet-686	396	4	e.	e.	PROPN
admet-686	396	5	galia	galia	PROPN
admet-686	396	6	,	,	PUNCT
admet-686	396	7	e.	e.	PROPN
admet-686	396	8	nicolaides	nicolaides	PROPN
admet-686	396	9	,	,	PUNCT
admet-686	396	10	d.	d.	PROPN
admet-686	396	11	horter	horter	PROPN
admet-686	396	12	,	,	PUNCT
admet-686	396	13	r.	r.	PROPN
admet-686	396	14	lobenberg	lobenberg	PROPN
admet-686	396	15	,	,	PUNCT
admet-686	396	16	c.	c.	PROPN
admet-686	396	17	reppas	reppas	PROPN
admet-686	396	18	,	,	PUNCT
admet-686	397	1	j.b	j.b	PROPN
admet-686	397	2	.	.	PROPN
admet-686	397	3	dressman	dressman	PROPN
admet-686	397	4	.	.	PUNCT
admet-686	398	1	evaluation	evaluation	NOUN
admet-686	398	2	of	of	ADP
admet-686	398	3	various	various	ADJ
admet-686	398	4	dissolution	dissolution	NOUN
admet-686	398	5	media	medium	NOUN
admet-686	398	6	for	for	ADP
admet-686	398	7	predicting	predict	VERB
admet-686	398	8	in	in	ADP
admet-686	398	9	vivo	vivo	ADJ
admet-686	398	10	performance	performance	NOUN
admet-686	398	11	of	of	ADP
admet-686	398	12	class	class	NOUN
admet-686	398	13	i	i	PROPN
admet-686	398	14	and	and	CCONJ
admet-686	398	15	ii	ii	PROPN
admet-686	398	16	drugs	drug	NOUN
admet-686	398	17	.	.	PUNCT
admet-686	399	1	pharm	pharm	NOUN
admet-686	399	2	.	.	PUNCT
admet-686	400	1	res	re	NOUN
admet-686	400	2	.	.	PROPN
admet-686	401	1	15	15	NUM
admet-686	401	2	(	(	PUNCT
admet-686	401	3	1998	1998	NUM
admet-686	401	4	)	)	PUNCT
admet-686	401	5	698	698	NUM
admet-686	401	6	-	-	SYM
admet-686	401	7	705	705	NUM
admet-686	401	8	.	.	PUNCT
admet-686	402	1	[	[	X
admet-686	402	2	16	16	NUM
admet-686	402	3	]	]	X
admet-686	402	4	i.	i.	PROPN
admet-686	402	5	khadra	khadra	PROPN
admet-686	402	6	,	,	PUNCT
admet-686	402	7	z.	z.	PROPN
admet-686	402	8	zhou	zhou	PROPN
admet-686	402	9	,	,	PUNCT
admet-686	402	10	c.	c.	PROPN
admet-686	402	11	dunn	dunn	PROPN
admet-686	402	12	,	,	PUNCT
admet-686	402	13	c.g	c.g	PROPN
admet-686	402	14	.	.	PROPN
admet-686	402	15	wilson	wilson	PROPN
admet-686	402	16	,	,	PUNCT
admet-686	402	17	g.	g.	PROPN
admet-686	402	18	halbert	halbert	PROPN
admet-686	402	19	.	.	PUNCT
admet-686	403	1	statistical	statistical	ADJ
admet-686	403	2	investigation	investigation	NOUN
admet-686	403	3	of	of	ADP
admet-686	403	4	simulated	simulated	ADJ
admet-686	403	5	intestinal	intestinal	ADJ
admet-686	403	6	fluid	fluid	NOUN
admet-686	403	7	composition	composition	NOUN
admet-686	403	8	on	on	ADP
admet-686	403	9	the	the	DET
admet-686	403	10	equilibrium	equilibrium	NOUN
admet-686	403	11	solubility	solubility	NOUN
admet-686	403	12	of	of	ADP
admet-686	403	13	biopharmaceutics	biopharmaceutics	NOUN
admet-686	403	14	classification	classification	NOUN
admet-686	403	15	system	system	NOUN
admet-686	403	16	class	class	NOUN
admet-686	403	17	ii	ii	NOUN
admet-686	403	18	drugs	drug	NOUN
admet-686	403	19	.	.	PUNCT
admet-686	404	1	eur	eur	PROPN
admet-686	404	2	.	.	PUNCT
admet-686	405	1	j.	j.	PROPN
admet-686	405	2	pharm	pharm	PROPN
admet-686	405	3	.	.	PUNCT
admet-686	406	1	sci	sci	PROPN
admet-686	406	2	.	.	PROPN
admet-686	407	1	67	67	NUM
admet-686	407	2	(	(	PUNCT
admet-686	407	3	2015	2015	NUM
admet-686	407	4	)	)	PUNCT
admet-686	407	5	65	65	NUM
admet-686	407	6	-	-	SYM
admet-686	407	7	75	75	NUM
admet-686	407	8	.	.	PUNCT
admet-686	408	1	[	[	X
admet-686	408	2	17	17	NUM
admet-686	408	3	]	]	X
admet-686	408	4	g.	g.	PROPN
admet-686	408	5	zografi	zografi	PROPN
admet-686	408	6	,	,	PUNCT
admet-686	408	7	i.	i.	PROPN
admet-686	408	8	zarenda	zarenda	PROPN
admet-686	408	9	.	.	PUNCT
admet-686	409	1	the	the	DET
admet-686	409	2	surface	surface	NOUN
admet-686	409	3	activity	activity	NOUN
admet-686	409	4	of	of	ADP
admet-686	409	5	phenothiazine	phenothiazine	NOUN
admet-686	409	6	derivatives	derivative	NOUN
admet-686	409	7	at	at	ADP
admet-686	409	8	the	the	DET
admet-686	409	9	air	air	NOUN
admet-686	409	10	-	-	PUNCT
admet-686	409	11	solution	solution	NOUN
admet-686	409	12	interface	interface	NOUN
admet-686	409	13	.	.	PUNCT
admet-686	410	1	biochem	biochem	PROPN
admet-686	410	2	.	.	PUNCT
admet-686	411	1	pharmacol	pharmacol	PROPN
admet-686	411	2	.	.	PROPN
admet-686	412	1	15	15	NUM
admet-686	412	2	(	(	PUNCT
admet-686	412	3	1966	1966	NUM
admet-686	412	4	)	)	PUNCT
admet-686	412	5	591	591	NUM
admet-686	412	6	-	-	SYM
admet-686	412	7	598	598	NUM
admet-686	412	8	.	.	PUNCT
admet-686	413	1	[	[	X
admet-686	413	2	18	18	NUM
admet-686	413	3	]	]	X
admet-686	413	4	h.l	h.l	PROPN
admet-686	413	5	.	.	PROPN
admet-686	413	6	lee	lee	PROPN
admet-686	413	7	,	,	PUNCT
admet-686	413	8	j.m	j.m	PROPN
admet-686	413	9	.	.	PROPN
admet-686	413	10	vasoya	vasoya	PROPN
admet-686	413	11	,	,	PUNCT
admet-686	413	12	m	m	PROPN
admet-686	413	13	de	de	PROPN
admet-686	413	14	l.	l.	PROPN
admet-686	413	15	cirqueira	cirqueira	PROPN
admet-686	413	16	,	,	PUNCT
admet-686	413	17	k.l	k.l	PROPN
admet-686	413	18	.	.	PROPN
admet-686	413	19	yeh	yeh	PROPN
admet-686	413	20	,	,	PUNCT
admet-686	413	21	t.	t.	PROPN
admet-686	413	22	lee	lee	PROPN
admet-686	413	23	,	,	PUNCT
admet-686	413	24	a.t.m	a.t.m	PROPN
admet-686	413	25	.	.	PUNCT
admet-686	413	26	serajuddin	serajuddin	VERB
admet-686	413	27	.	.	PUNCT
admet-686	414	1	continuous	continuous	ADJ
admet-686	414	2	preparation	preparation	NOUN
admet-686	414	3	of	of	ADP
admet-686	414	4	1:1	1:1	NUM
admet-686	414	5	haloperidol	haloperidol	NOUN
admet-686	414	6	-	-	PUNCT
admet-686	414	7	maleic	maleic	VERB
admet-686	414	8	acid	acid	NOUN
admet-686	414	9	salt	salt	NOUN
admet-686	414	10	by	by	ADP
admet-686	414	11	a	a	DET
admet-686	414	12	novel	novel	ADJ
admet-686	414	13	solvent	solvent	NOUN
admet-686	414	14	-	-	PUNCT
admet-686	414	15	free	free	ADJ
admet-686	414	16	method	method	NOUN
admet-686	414	17	using	use	VERB
admet-686	414	18	a	a	DET
admet-686	414	19	twin	twin	ADJ
admet-686	414	20	screw	screw	NOUN
admet-686	414	21	melt	melt	NOUN
admet-686	414	22	extruder	extruder	NOUN
admet-686	414	23	.	.	PUNCT
admet-686	415	1	mol	mol	PROPN
admet-686	415	2	.	.	PUNCT
admet-686	416	1	pharmaceutics	pharmaceutic	NOUN
admet-686	416	2	14	14	NUM
admet-686	416	3	(	(	PUNCT
admet-686	416	4	2017	2017	NUM
admet-686	416	5	)	)	PUNCT
admet-686	416	6	1278	1278	NUM
admet-686	416	7	-	-	SYM
admet-686	416	8	1291	1291	NUM
admet-686	416	9	.	.	PUNCT
admet-686	417	1	[	[	X
admet-686	417	2	19	19	NUM
admet-686	417	3	]	]	X
admet-686	417	4	s.	s.	PROPN
admet-686	417	5	li	li	PROPN
admet-686	417	6	,	,	PUNCT
admet-686	417	7	s.	s.	PROPN
admet-686	417	8	wong	wong	PROPN
admet-686	417	9	,	,	PUNCT
admet-686	417	10	s.	s.	PROPN
admet-686	417	11	sethia	sethia	PROPN
admet-686	417	12	,	,	PUNCT
admet-686	417	13	h.	h.	PROPN
admet-686	417	14	almoazen	almoazen	PROPN
admet-686	417	15	,	,	PUNCT
admet-686	417	16	y.m	y.m	PROPN
admet-686	417	17	.	.	PROPN
admet-686	417	18	joshi	joshi	PROPN
admet-686	417	19	,	,	PUNCT
admet-686	417	20	a.t.m	a.t.m	AUX
admet-686	417	21	.	.	PUNCT
admet-686	417	22	serajuddin	serajuddin	PROPN
admet-686	417	23	.	.	PUNCT
admet-686	418	1	investigation	investigation	NOUN
admet-686	418	2	of	of	ADP
admet-686	418	3	solubility	solubility	NOUN
admet-686	418	4	and	and	CCONJ
admet-686	418	5	dissolution	dissolution	NOUN
admet-686	418	6	of	of	ADP
admet-686	418	7	a	a	DET
admet-686	418	8	free	free	ADJ
admet-686	418	9	base	base	NOUN
admet-686	418	10	and	and	CCONJ
admet-686	418	11	two	two	NUM
admet-686	418	12	different	different	ADJ
admet-686	418	13	salt	salt	NOUN
admet-686	418	14	forms	form	NOUN
admet-686	418	15	as	as	ADP
admet-686	418	16	a	a	DET
admet-686	418	17	function	function	NOUN
admet-686	418	18	of	of	ADP
admet-686	418	19	ph	ph	PROPN
admet-686	418	20	.	.	PROPN
admet-686	418	21	pharm	pharm	PROPN
admet-686	418	22	.	.	PUNCT
admet-686	419	1	res	re	NOUN
admet-686	419	2	.	.	PUNCT
admet-686	420	1	22	22	NUM
admet-686	420	2	(	(	PUNCT
admet-686	420	3	2005	2005	NUM
admet-686	420	4	)	)	PUNCT
admet-686	420	5	628635	628635	NUM
admet-686	420	6	.	.	PUNCT
admet-686	421	1	admet	admet	PROPN
admet-686	421	2	&	&	CCONJ
admet-686	421	3	dmpk	dmpk	PROPN
admet-686	421	4	7(2	7(2	NUM
admet-686	421	5	)	)	PUNCT
admet-686	421	6	(	(	PUNCT
admet-686	421	7	2019	2019	NUM
admet-686	421	8	)	)	PUNCT
admet-686	421	9	88	88	NUM
admet-686	421	10	-	-	SYM
admet-686	421	11	105	105	NUM
admet-686	421	12	perspectives	perspective	NOUN
admet-686	421	13	in	in	ADP
admet-686	421	14	solubility	solubility	NOUN
admet-686	421	15	measurements	measurement	NOUN
admet-686	421	16	and	and	CCONJ
admet-686	421	17	interpretation	interpretation	NOUN
admet-686	421	18	doi	doi	PROPN
admet-686	421	19	:	:	PUNCT
admet-686	421	20	10.5599	10.5599	NUM
admet-686	421	21	/	/	SYM
admet-686	421	22	admet.686	admet.686	PRON
admet-686	421	23	103	103	NUM
admet-686	421	24	[	[	SYM
admet-686	421	25	20	20	NUM
admet-686	421	26	]	]	X
admet-686	421	27	m.m	m.m	PROPN
admet-686	421	28	.	.	PROPN
admet-686	421	29	al	al	PROPN
admet-686	421	30	omari	omari	PROPN
admet-686	421	31	,	,	PUNCT
admet-686	421	32	m.b	m.b	PROPN
admet-686	421	33	.	.	PROPN
admet-686	421	34	zughul	zughul	PROPN
admet-686	421	35	,	,	PUNCT
admet-686	421	36	j.e.d	j.e.d	PROPN
admet-686	421	37	.	.	PUNCT
admet-686	422	1	davies	davies	PROPN
admet-686	422	2	,	,	PUNCT
admet-686	422	3	a.a	a.a	PROPN
admet-686	422	4	.	.	PROPN
admet-686	422	5	badwan	badwan	PROPN
admet-686	422	6	.	.	PUNCT
admet-686	423	1	a	a	DET
admet-686	423	2	study	study	NOUN
admet-686	423	3	of	of	ADP
admet-686	423	4	haloperidol	haloperidol	ADJ
admet-686	423	5	inclusion	inclusion	NOUN
admet-686	423	6	complexes	complex	NOUN
admet-686	423	7	with	with	ADP
admet-686	423	8	β	β	NOUN
admet-686	423	9	-	-	NOUN
admet-686	423	10	cyclodextrin	cyclodextrin	NOUN
admet-686	423	11	using	use	VERB
admet-686	423	12	phase	phase	NOUN
admet-686	423	13	solubility	solubility	NOUN
admet-686	423	14	,	,	PUNCT
admet-686	423	15	nmr	nmr	NOUN
admet-686	423	16	spectroscopy	spectroscopy	NOUN
admet-686	423	17	and	and	CCONJ
admet-686	423	18	molecular	molecular	ADJ
admet-686	423	19	modeling	modeling	NOUN
admet-686	423	20	techniques	technique	NOUN
admet-686	423	21	.	.	PUNCT
admet-686	424	1	j.	j.	PROPN
admet-686	424	2	solution	solution	PROPN
admet-686	424	3	.	.	PUNCT
admet-686	425	1	chem	chem	NOUN
admet-686	425	2	.	.	PUNCT
admet-686	426	1	38	38	NUM
admet-686	426	2	(	(	PUNCT
admet-686	426	3	2009	2009	NUM
admet-686	426	4	)	)	PUNCT
admet-686	426	5	669	669	NUM
admet-686	426	6	-	-	SYM
admet-686	426	7	683	683	NUM
admet-686	426	8	.	.	PUNCT
admet-686	427	1	[	[	X
admet-686	427	2	21	21	NUM
admet-686	427	3	]	]	PUNCT
admet-686	427	4	c.a.s	c.a.s	PROPN
admet-686	427	5	.	.	PROPN
admet-686	427	6	bergström	bergström	PROPN
admet-686	427	7	,	,	PUNCT
admet-686	427	8	k.	k.	PROPN
admet-686	427	9	luthman	luthman	PROPN
admet-686	427	10	,	,	PUNCT
admet-686	427	11	p.	p.	PROPN
admet-686	427	12	artursson	artursson	PROPN
admet-686	427	13	.	.	PUNCT
admet-686	428	1	accuracy	accuracy	NOUN
admet-686	428	2	of	of	ADP
admet-686	428	3	calculated	calculated	ADJ
admet-686	428	4	ph	ph	ADJ
admet-686	428	5	-	-	ADJ
admet-686	428	6	dependent	dependent	ADJ
admet-686	428	7	aqueous	aqueous	ADJ
admet-686	428	8	drug	drug	NOUN
admet-686	428	9	solubility	solubility	NOUN
admet-686	428	10	.	.	PUNCT
admet-686	429	1	eur	eur	PROPN
admet-686	429	2	.	.	PUNCT
admet-686	430	1	j.	j.	PROPN
admet-686	430	2	pharm	pharm	PROPN
admet-686	430	3	.	.	PUNCT
admet-686	431	1	sci	sci	PROPN
admet-686	431	2	.	.	PROPN
admet-686	432	1	22	22	NUM
admet-686	432	2	(	(	PUNCT
admet-686	432	3	2004	2004	NUM
admet-686	432	4	)	)	PUNCT
admet-686	432	5	387	387	NUM
admet-686	432	6	-	-	SYM
admet-686	432	7	398	398	NUM
admet-686	432	8	.	.	PUNCT
admet-686	433	1	[	[	X
admet-686	433	2	22	22	NUM
admet-686	433	3	]	]	X
admet-686	433	4	g.	g.	PROPN
admet-686	433	5	völgyi	völgyi	PROPN
admet-686	433	6	,	,	PUNCT
admet-686	433	7	a.	a.	NOUN
admet-686	433	8	marosi	marosi	PROPN
admet-686	433	9	,	,	PUNCT
admet-686	433	10	k.	k.	PROPN
admet-686	433	11	takács	takács	PROPN
admet-686	433	12	-	-	PUNCT
admet-686	433	13	novák	novák	PROPN
admet-686	433	14	,	,	PUNCT
admet-686	433	15	a.	a.	NOUN
admet-686	433	16	avdeef	avdeef	PROPN
admet-686	433	17	.	.	PUNCT
admet-686	434	1	salt	salt	NOUN
admet-686	434	2	solubility	solubility	NOUN
admet-686	434	3	products	product	NOUN
admet-686	434	4	of	of	ADP
admet-686	434	5	diprenorphine	diprenorphine	NOUN
admet-686	434	6	hydrochloride	hydrochloride	NOUN
admet-686	434	7	,	,	PUNCT
admet-686	434	8	codeine	codeine	NOUN
admet-686	434	9	and	and	CCONJ
admet-686	434	10	lidocaine	lidocaine	NOUN
admet-686	434	11	hydrochlorides	hydrochloride	NOUN
admet-686	434	12	and	and	CCONJ
admet-686	434	13	phosphates	phosphate	NOUN
admet-686	434	14	–	–	PUNCT
admet-686	434	15	novel	novel	NOUN
admet-686	434	16	method	method	NOUN
admet-686	434	17	of	of	ADP
admet-686	434	18	data	datum	NOUN
admet-686	434	19	analysis	analysis	NOUN
admet-686	434	20	not	not	PART
admet-686	434	21	dependent	dependent	ADJ
admet-686	434	22	on	on	ADP
admet-686	434	23	explicit	explicit	ADJ
admet-686	434	24	solubility	solubility	NOUN
admet-686	434	25	equations	equation	NOUN
admet-686	434	26	.	.	PUNCT
admet-686	435	1	admet	admet	PROPN
admet-686	435	2	&	&	CCONJ
admet-686	435	3	dmpk	dmpk	PROPN
admet-686	435	4	1	1	NUM
admet-686	435	5	(	(	PUNCT
admet-686	435	6	2013	2013	NUM
admet-686	435	7	)	)	PUNCT
admet-686	435	8	48	48	NUM
admet-686	435	9	-	-	SYM
admet-686	435	10	62	62	NUM
admet-686	435	11	.	.	PUNCT
admet-686	436	1	[	[	X
admet-686	436	2	23	23	NUM
admet-686	436	3	]	]	PUNCT
admet-686	436	4	a.	a.	NOUN
admet-686	436	5	avdeef	avdeef	PROPN
admet-686	436	6	.	.	PUNCT
admet-686	437	1	solubility	solubility	NOUN
admet-686	437	2	temperature	temperature	NOUN
admet-686	437	3	dependence	dependence	NOUN
admet-686	437	4	predicted	predict	VERB
admet-686	437	5	from	from	ADP
admet-686	437	6	2d	2d	NUM
admet-686	437	7	structure	structure	NOUN
admet-686	437	8	.	.	PUNCT
admet-686	438	1	admet	admet	PROPN
admet-686	438	2	&	&	CCONJ
admet-686	438	3	dmpk	dmpk	PROPN
admet-686	438	4	3	3	NUM
admet-686	438	5	(	(	PUNCT
admet-686	438	6	2015	2015	NUM
admet-686	438	7	)	)	PUNCT
admet-686	438	8	298	298	NUM
admet-686	438	9	-	-	SYM
admet-686	438	10	344	344	NUM
admet-686	438	11	.	.	PUNCT
admet-686	439	1	[	[	X
admet-686	439	2	24	24	NUM
admet-686	439	3	]	]	PUNCT
admet-686	439	4	a.	a.	NOUN
admet-686	439	5	avdeef	avdeef	PROPN
admet-686	439	6	.	.	PUNCT
admet-686	440	1	unpublished	unpublished	ADJ
admet-686	440	2	results	result	NOUN
admet-686	440	3	(	(	PUNCT
admet-686	440	4	2018	2018	NUM
admet-686	440	5	)	)	PUNCT
admet-686	440	6	.	.	PUNCT
admet-686	441	1	[	[	X
admet-686	441	2	25	25	NUM
admet-686	441	3	]	]	X
admet-686	441	4	d.s	d.s	PROPN
admet-686	441	5	.	.	PROPN
admet-686	441	6	palmer	palmer	PROPN
admet-686	441	7	,	,	PUNCT
admet-686	441	8	j.b.o	j.b.o	PROPN
admet-686	441	9	.	.	PROPN
admet-686	441	10	mitchell	mitchell	PROPN
admet-686	441	11	.	.	PUNCT
admet-686	441	12	is	be	AUX
admet-686	441	13	experimental	experimental	ADJ
admet-686	441	14	data	datum	NOUN
admet-686	441	15	quality	quality	NOUN
admet-686	441	16	the	the	DET
admet-686	441	17	limiting	limit	VERB
admet-686	441	18	factor	factor	NOUN
admet-686	441	19	in	in	ADP
admet-686	441	20	predicting	predict	VERB
admet-686	441	21	the	the	DET
admet-686	441	22	aqueous	aqueous	ADJ
admet-686	441	23	solubility	solubility	NOUN
admet-686	441	24	of	of	ADP
admet-686	441	25	druglike	druglike	ADJ
admet-686	441	26	molecules	molecule	NOUN
admet-686	441	27	?	?	PUNCT
admet-686	441	28	.	.	PUNCT
admet-686	442	1	mol	mol	PROPN
admet-686	442	2	.	.	PUNCT
admet-686	443	1	pharmaceutics	pharmaceutic	NOUN
admet-686	443	2	11	11	NUM
admet-686	443	3	(	(	PUNCT
admet-686	443	4	2014	2014	NUM
admet-686	443	5	)	)	PUNCT
admet-686	443	6	2962	2962	NUM
admet-686	443	7	-	-	SYM
admet-686	443	8	2972	2972	NUM
admet-686	443	9	.	.	PUNCT
admet-686	444	1	[	[	X
admet-686	444	2	26	26	NUM
admet-686	444	3	]	]	PUNCT
admet-686	444	4	s.	s.	PROPN
admet-686	444	5	veesler	veesler	PROPN
admet-686	444	6	,	,	PUNCT
admet-686	444	7	l.	l.	PROPN
admet-686	444	8	lafferrère	lafferrère	PROPN
admet-686	444	9	,	,	PUNCT
admet-686	444	10	e.	e.	PROPN
admet-686	444	11	garcia	garcia	PROPN
admet-686	444	12	,	,	PUNCT
admet-686	444	13	c.	c.	PROPN
admet-686	444	14	hoff	hoff	PROPN
admet-686	444	15	.	.	PUNCT
admet-686	445	1	phase	phase	NOUN
admet-686	445	2	transitions	transition	NOUN
admet-686	445	3	in	in	ADP
admet-686	445	4	supersaturated	supersaturated	ADJ
admet-686	445	5	drug	drug	NOUN
admet-686	445	6	solution	solution	NOUN
admet-686	445	7	.	.	PUNCT
admet-686	446	1	org	org	NOUN
admet-686	446	2	.	.	PUNCT
admet-686	447	1	proc	proc	PROPN
admet-686	447	2	.	.	PUNCT
admet-686	448	1	res	re	NOUN
admet-686	448	2	.	.	PUNCT
admet-686	449	1	dev	dev	PROPN
admet-686	449	2	.	.	PROPN
admet-686	449	3	7	7	NUM
admet-686	449	4	(	(	PUNCT
admet-686	449	5	2003	2003	NUM
admet-686	449	6	)	)	PUNCT
admet-686	449	7	983	983	NUM
admet-686	449	8	-	-	SYM
admet-686	449	9	989	989	NUM
admet-686	449	10	.	.	PUNCT
admet-686	450	1	[	[	X
admet-686	450	2	27	27	NUM
admet-686	450	3	]	]	X
admet-686	450	4	p.e	p.e	PROPN
admet-686	450	5	.	.	PROPN
admet-686	450	6	bonnett	bonnett	PROPN
admet-686	450	7	,	,	PUNCT
admet-686	450	8	k.j	k.j	PROPN
admet-686	450	9	.	.	PROPN
admet-686	450	10	carpenter	carpenter	PROPN
admet-686	450	11	,	,	PUNCT
admet-686	450	12	s.	s.	PROPN
admet-686	450	13	dawson	dawson	PROPN
admet-686	450	14	,	,	PUNCT
admet-686	450	15	r.j	r.j	PROPN
admet-686	450	16	.	.	PROPN
admet-686	450	17	davey	davey	PROPN
admet-686	450	18	.	.	PUNCT
admet-686	450	19	solution	solution	NOUN
admet-686	450	20	crystallization	crystallization	NOUN
admet-686	450	21	via	via	ADP
admet-686	450	22	a	a	DET
admet-686	450	23	submerged	submerge	VERB
admet-686	450	24	liquid	liquid	NOUN
admet-686	450	25	–	–	PUNCT
admet-686	450	26	liquid	liquid	ADJ
admet-686	450	27	phase	phase	NOUN
admet-686	450	28	boundary	boundary	NOUN
admet-686	450	29	:	:	PUNCT
admet-686	450	30	oiling	oil	VERB
admet-686	450	31	out	out	ADP
admet-686	450	32	.	.	PUNCT
admet-686	451	1	chem	chem	NOUN
admet-686	451	2	.	.	PUNCT
admet-686	452	1	commun	commun	PROPN
admet-686	452	2	.	.	PUNCT
admet-686	453	1	(	(	PUNCT
admet-686	453	2	2003	2003	NUM
admet-686	453	3	)	)	PUNCT
admet-686	454	1	698–699	698–699	NUM
admet-686	454	2	.	.	PUNCT
admet-686	455	1	[	[	X
admet-686	455	2	28	28	NUM
admet-686	455	3	]	]	X
admet-686	455	4	a.	a.	NOUN
admet-686	455	5	avdeef	avdeef	PROPN
admet-686	455	6	.	.	PUNCT
admet-686	456	1	absorption	absorption	NOUN
admet-686	456	2	and	and	CCONJ
admet-686	456	3	drug	drug	NOUN
admet-686	456	4	development	development	PROPN
admet-686	456	5	second	second	PROPN
admet-686	456	6	edition	edition	NOUN
admet-686	456	7	,	,	PUNCT
admet-686	456	8	wiley	wiley	NOUN
admet-686	456	9	-	-	PUNCT
admet-686	456	10	interscience	interscience	PROPN
admet-686	456	11	,	,	PUNCT
admet-686	456	12	hoboken	hoboken	PROPN
admet-686	456	13	nj	nj	PROPN
admet-686	456	14	,	,	PUNCT
admet-686	456	15	2012	2012	NUM
admet-686	456	16	.	.	PUNCT
admet-686	457	1	[	[	X
admet-686	457	2	29	29	NUM
admet-686	457	3	]	]	X
admet-686	457	4	m.m	m.m	PROPN
admet-686	457	5	.	.	PROPN
admet-686	457	6	al	al	PROPN
admet-686	457	7	omari	omari	PROPN
admet-686	457	8	,	,	PUNCT
admet-686	457	9	m.b	m.b	PROPN
admet-686	457	10	.	.	PROPN
admet-686	457	11	zughul	zughul	PROPN
admet-686	457	12	,	,	PUNCT
admet-686	457	13	j.e.d	j.e.d	PROPN
admet-686	457	14	.	.	PUNCT
admet-686	457	15	davies	davies	PROPN
admet-686	457	16	,	,	PUNCT
admet-686	457	17	a.a	a.a	PROPN
admet-686	457	18	.	.	PROPN
admet-686	457	19	badwan	badwan	PROPN
admet-686	457	20	.	.	PUNCT
admet-686	458	1	effect	effect	NOUN
admet-686	458	2	of	of	ADP
admet-686	458	3	buffer	buffer	NOUN
admet-686	458	4	species	specie	NOUN
admet-686	458	5	on	on	ADP
admet-686	458	6	the	the	DET
admet-686	458	7	complexation	complexation	NOUN
admet-686	458	8	of	of	ADP
admet-686	458	9	basic	basic	ADJ
admet-686	458	10	drug	drug	NOUN
admet-686	458	11	terfenadine	terfenadine	NOUN
admet-686	458	12	with	with	ADP
admet-686	458	13	β	β	NOUN
admet-686	458	14	-	-	NOUN
admet-686	458	15	cyclodextrin	cyclodextrin	NOUN
admet-686	458	16	.	.	PUNCT
admet-686	459	1	j.	j.	PROPN
admet-686	459	2	inclus	inclus	PROPN
admet-686	459	3	.	.	PUNCT
admet-686	460	1	phenom	phenom	PROPN
admet-686	460	2	.	.	PUNCT
admet-686	461	1	macrocycl	macrocycl	PROPN
admet-686	461	2	.	.	PUNCT
admet-686	461	3	chem	chem	NOUN
admet-686	461	4	.	.	PUNCT
admet-686	462	1	58	58	NUM
admet-686	462	2	(	(	PUNCT
admet-686	462	3	2007	2007	NUM
admet-686	462	4	)	)	PUNCT
admet-686	462	5	227	227	NUM
admet-686	462	6	-	-	SYM
admet-686	462	7	235	235	NUM
admet-686	462	8	.	.	PUNCT
admet-686	463	1	[	[	X
admet-686	463	2	30	30	NUM
admet-686	463	3	]	]	X
admet-686	463	4	a.s	a.s	PROPN
admet-686	463	5	.	.	PROPN
admet-686	463	6	indulkar	indulkar	PROPN
admet-686	463	7	,	,	PUNCT
admet-686	463	8	k.j	k.j	PROPN
admet-686	463	9	.	.	PROPN
admet-686	463	10	box	box	PROPN
admet-686	463	11	,	,	PUNCT
admet-686	463	12	r.	r.	PROPN
admet-686	463	13	taylor	taylor	PROPN
admet-686	463	14	,	,	PUNCT
admet-686	463	15	r.	r.	PROPN
admet-686	463	16	ruiz	ruiz	PROPN
admet-686	463	17	,	,	PUNCT
admet-686	463	18	l.s	l.s	PROPN
admet-686	463	19	.	.	PROPN
admet-686	463	20	taylor	taylor	PROPN
admet-686	463	21	.	.	PUNCT
admet-686	464	1	ph	ph	VERB
admet-686	464	2	-	-	ADJ
admet-686	464	3	dependent	dependent	ADJ
admet-686	464	4	liquid−liquid	liquid−liquid	NOUN
admet-686	464	5	phase	phase	NOUN
admet-686	464	6	separation	separation	NOUN
admet-686	464	7	of	of	ADP
admet-686	464	8	highly	highly	ADV
admet-686	464	9	supersaturated	supersaturated	ADJ
admet-686	464	10	solutions	solution	NOUN
admet-686	464	11	of	of	ADP
admet-686	464	12	weakly	weakly	ADJ
admet-686	464	13	basic	basic	ADJ
admet-686	464	14	drugs	drug	NOUN
admet-686	464	15	.	.	PUNCT
admet-686	465	1	mol	mol	PROPN
admet-686	465	2	.	.	PUNCT
admet-686	466	1	pharmaceutics	pharmaceutic	NOUN
admet-686	466	2	12	12	NUM
admet-686	466	3	(	(	PUNCT
admet-686	466	4	2015	2015	NUM
admet-686	466	5	)	)	PUNCT
admet-686	466	6	2365	2365	NUM
admet-686	466	7	-	-	SYM
admet-686	466	8	2377	2377	NUM
admet-686	466	9	.	.	PUNCT
admet-686	467	1	[	[	X
admet-686	467	2	31	31	NUM
admet-686	467	3	]	]	X
admet-686	467	4	d.	d.	PROPN
admet-686	467	5	gebauer	gebauer	PROPN
admet-686	467	6	,	,	PUNCT
admet-686	467	7	m.	m.	NOUN
admet-686	467	8	kellermeier	kellermeier	PROPN
admet-686	467	9	,	,	PUNCT
admet-686	467	10	j.d	j.d	PROPN
admet-686	467	11	.	.	PROPN
admet-686	467	12	gale	gale	PROPN
admet-686	467	13	,	,	PUNCT
admet-686	467	14	l.	l.	PROPN
admet-686	467	15	bergström	bergström	PROPN
admet-686	467	16	,	,	PUNCT
admet-686	467	17	h.	h.	PROPN
admet-686	467	18	cölfen	cölfen	NOUN
admet-686	467	19	.	.	PUNCT
admet-686	468	1	pre	pre	ADJ
admet-686	468	2	-	-	ADJ
admet-686	468	3	nucleation	nucleation	ADJ
admet-686	468	4	clusters	cluster	NOUN
admet-686	468	5	as	as	ADP
admet-686	468	6	solute	solute	NOUN
admet-686	468	7	precursors	precursor	NOUN
admet-686	468	8	in	in	ADP
admet-686	468	9	crystallization	crystallization	NOUN
admet-686	468	10	.	.	PUNCT
admet-686	469	1	chem	chem	NOUN
admet-686	469	2	.	.	PUNCT
admet-686	470	1	soc	soc	PROPN
admet-686	470	2	.	.	PUNCT
admet-686	471	1	rev	rev	PROPN
admet-686	471	2	.	.	PROPN
admet-686	471	3	,	,	PUNCT
admet-686	471	4	43	43	NUM
admet-686	471	5	(	(	PUNCT
admet-686	471	6	2014	2014	NUM
admet-686	471	7	)	)	PUNCT
admet-686	471	8	2348	2348	NUM
admet-686	471	9	-	-	PUNCT
admet-686	471	10	2371	2371	NUM
admet-686	471	11	.	.	PUNCT
admet-686	472	1	[	[	X
admet-686	472	2	32	32	NUM
admet-686	472	3	]	]	PUNCT
admet-686	472	4	a.	a.	NOUN
admet-686	472	5	pobudkowska	pobudkowska	PROPN
admet-686	472	6	,	,	PUNCT
admet-686	472	7	c.	c.	PROPN
admet-686	472	8	ràfols	ràfol	NOUN
admet-686	472	9	,	,	PUNCT
admet-686	472	10	x.	x.	NOUN
admet-686	472	11	subirats	subirats	PROPN
admet-686	472	12	,	,	PUNCT
admet-686	472	13	e.	e.	PROPN
admet-686	472	14	bosch	bosch	PROPN
admet-686	472	15	,	,	PUNCT
admet-686	472	16	a.	a.	PROPN
admet-686	472	17	avdeef	avdeef	PROPN
admet-686	472	18	.	.	PUNCT
admet-686	473	1	phenothiazines	phenothiazine	NOUN
admet-686	473	2	solution	solution	NOUN
admet-686	473	3	complexity	complexity	NOUN
admet-686	473	4	–	–	PUNCT
admet-686	473	5	determination	determination	NOUN
admet-686	473	6	of	of	ADP
admet-686	473	7	pka	pka	PROPN
admet-686	473	8	and	and	CCONJ
admet-686	473	9	solubility	solubility	NOUN
admet-686	473	10	-	-	PUNCT
admet-686	473	11	ph	ph	ADJ
admet-686	473	12	profiles	profile	NOUN
admet-686	473	13	exhibiting	exhibit	VERB
admet-686	473	14	sub	sub	ADJ
admet-686	473	15	-	-	ADJ
admet-686	473	16	micellar	micellar	ADJ
admet-686	473	17	aggregation	aggregation	NOUN
admet-686	473	18	at	at	ADP
admet-686	473	19	25	25	NUM
admet-686	473	20	and	and	CCONJ
admet-686	473	21	37	37	NUM
admet-686	473	22	°	°	NOUN
admet-686	473	23	c	c	NOUN
admet-686	473	24	.	.	PUNCT
admet-686	474	1	eur	eur	PROPN
admet-686	474	2	.	.	PUNCT
admet-686	475	1	j.	j.	PROPN
admet-686	475	2	pharm	pharm	PROPN
admet-686	475	3	.	.	PUNCT
admet-686	476	1	sci	sci	PROPN
admet-686	476	2	.	.	PROPN
admet-686	477	1	93	93	NUM
admet-686	477	2	(	(	PUNCT
admet-686	477	3	2016	2016	NUM
admet-686	477	4	)	)	PUNCT
admet-686	477	5	163	163	NUM
admet-686	477	6	-	-	SYM
admet-686	477	7	176	176	NUM
admet-686	477	8	.	.	PUNCT
admet-686	478	1	[	[	X
admet-686	478	2	33	33	NUM
admet-686	478	3	]	]	PUNCT
admet-686	478	4	k.	k.	PROPN
admet-686	478	5	edueng	edueng	PROPN
admet-686	478	6	,	,	PUNCT
admet-686	478	7	d.	d.	PROPN
admet-686	478	8	mahlin	mahlin	PROPN
admet-686	478	9	,	,	PUNCT
admet-686	478	10	p.	p.	PROPN
admet-686	478	11	larsson	larsson	PROPN
admet-686	478	12	,	,	PUNCT
admet-686	478	13	c.a.s	c.a.s	PROPN
admet-686	478	14	.	.	PROPN
admet-686	478	15	bergström	bergström	NOUN
admet-686	478	16	.	.	PUNCT
admet-686	479	1	mechanism	mechanism	NOUN
admet-686	479	2	-	-	PUNCT
admet-686	479	3	based	base	VERB
admet-686	479	4	selection	selection	NOUN
admet-686	479	5	of	of	ADP
admet-686	479	6	stabilisation	stabilisation	NOUN
admet-686	479	7	strategy	strategy	NOUN
admet-686	479	8	for	for	ADP
admet-686	479	9	amorphous	amorphous	ADJ
admet-686	479	10	formulations	formulation	NOUN
admet-686	479	11	:	:	PUNCT
admet-686	479	12	insights	insight	NOUN
admet-686	479	13	into	into	ADP
admet-686	479	14	crystallization	crystallization	NOUN
admet-686	479	15	pathways	pathway	NOUN
admet-686	479	16	.	.	PUNCT
admet-686	480	1	j.	j.	PROPN
admet-686	480	2	control	control	PROPN
admet-686	480	3	.	.	PUNCT
admet-686	481	1	rel	rel	PROPN
admet-686	481	2	.	.	PROPN
admet-686	482	1	256	256	NUM
admet-686	482	2	(	(	PUNCT
admet-686	482	3	2017	2017	NUM
admet-686	482	4	)	)	PUNCT
admet-686	482	5	193	193	NUM
admet-686	482	6	-	-	SYM
admet-686	482	7	202	202	NUM
admet-686	482	8	.	.	PUNCT
admet-686	483	1	[	[	X
admet-686	483	2	34	34	NUM
admet-686	483	3	]	]	PUNCT
admet-686	483	4	s.-y	s.-y	NOUN
admet-686	483	5	.	.	PUNCT
admet-686	484	1	p.	p.	NOUN
admet-686	484	2	king	king	PROPN
admet-686	484	3	,	,	PUNCT
admet-686	484	4	a.m.	a.m.	PROPN
admet-686	484	5	basista	basista	PROPN
admet-686	484	6	,	,	PUNCT
admet-686	484	7	g.	g.	PROPN
admet-686	484	8	oros	oros	PROPN
admet-686	484	9	.	.	PUNCT
admet-686	485	1	self	self	NOUN
admet-686	485	2	-	-	PUNCT
admet-686	485	3	association	association	NOUN
admet-686	485	4	and	and	CCONJ
admet-686	485	5	solubility	solubility	NOUN
admet-686	485	6	behaviors	behavior	NOUN
admet-686	485	7	of	of	ADP
admet-686	485	8	a	a	DET
admet-686	485	9	novel	novel	ADJ
admet-686	485	10	anticancer	anticancer	NOUN
admet-686	485	11	agent	agent	NOUN
admet-686	485	12	,	,	PUNCT
admet-686	485	13	brequinar	brequinar	NOUN
admet-686	485	14	sodium	sodium	NOUN
admet-686	485	15	.	.	PUNCT
admet-686	486	1	j.	j.	PROPN
admet-686	486	2	pharm	pharm	PROPN
admet-686	486	3	.	.	PUNCT
admet-686	487	1	sci	sci	PROPN
admet-686	487	2	.	.	PROPN
admet-686	488	1	78	78	NUM
admet-686	488	2	(	(	PUNCT
admet-686	488	3	1989	1989	NUM
admet-686	488	4	)	)	PUNCT
admet-686	488	5	95	95	NUM
admet-686	488	6	-	-	SYM
admet-686	488	7	100	100	NUM
admet-686	488	8	.	.	PUNCT
admet-686	489	1	[	[	X
admet-686	489	2	35	35	NUM
admet-686	489	3	]	]	X
admet-686	489	4	n.k	n.k	PROPN
admet-686	489	5	.	.	PROPN
admet-686	489	6	pandit	pandit	PROPN
admet-686	489	7	,	,	PUNCT
admet-686	489	8	j.m	j.m	PROPN
admet-686	489	9	.	.	PROPN
admet-686	489	10	strykowski	strykowski	PROPN
admet-686	489	11	.	.	PUNCT
admet-686	490	1	effect	effect	NOUN
admet-686	490	2	of	of	ADP
admet-686	490	3	temperature	temperature	NOUN
admet-686	490	4	on	on	ADP
admet-686	490	5	the	the	DET
admet-686	490	6	solubility	solubility	NOUN
admet-686	490	7	of	of	ADP
admet-686	490	8	a	a	DET
admet-686	490	9	surface	surface	NOUN
admet-686	490	10	active	active	ADJ
admet-686	490	11	carboxylic	carboxylic	ADJ
admet-686	490	12	acid	acid	NOUN
admet-686	490	13	.	.	PUNCT
admet-686	491	1	j.	j.	PROPN
admet-686	491	2	pharm	pharm	PROPN
admet-686	491	3	.	.	PUNCT
admet-686	492	1	sci	sci	PROPN
admet-686	492	2	.	.	PROPN
admet-686	493	1	78	78	NUM
admet-686	493	2	(	(	PUNCT
admet-686	493	3	1989	1989	NUM
admet-686	493	4	)	)	PUNCT
admet-686	493	5	767	767	NUM
admet-686	493	6	-	-	SYM
admet-686	493	7	770	770	NUM
admet-686	493	8	.	.	PUNCT
admet-686	494	1	[	[	X
admet-686	494	2	36	36	NUM
admet-686	494	3	]	]	X
admet-686	494	4	d.l	d.l	PROPN
admet-686	494	5	.	.	PROPN
admet-686	494	6	ross	ross	PROPN
admet-686	494	7	,	,	PUNCT
admet-686	494	8	c.m	c.m	PROPN
admet-686	494	9	.	.	PROPN
admet-686	494	10	riley	riley	PROPN
admet-686	494	11	.	.	PUNCT
admet-686	495	1	aqueous	aqueous	ADJ
admet-686	495	2	solubilities	solubility	NOUN
admet-686	495	3	of	of	ADP
admet-686	495	4	some	some	DET
admet-686	495	5	variously	variously	ADV
admet-686	495	6	substituted	substitute	VERB
admet-686	495	7	quinolone	quinolone	NOUN
admet-686	495	8	antimicrobials	antimicrobial	NOUN
admet-686	495	9	.	.	PUNCT
admet-686	496	1	int	int	NOUN
admet-686	496	2	.	.	PUNCT
admet-686	497	1	j.	j.	PROPN
admet-686	497	2	pharm	pharm	PROPN
admet-686	497	3	.	.	PUNCT
admet-686	498	1	63	63	NUM
admet-686	498	2	(	(	PUNCT
admet-686	498	3	1990	1990	NUM
admet-686	498	4	)	)	PUNCT
admet-686	498	5	237	237	NUM
admet-686	498	6	-	-	SYM
admet-686	498	7	250	250	NUM
admet-686	498	8	.	.	PUNCT
admet-686	499	1	[	[	X
admet-686	499	2	37	37	NUM
admet-686	499	3	]	]	PUNCT
admet-686	499	4	h.-c	h.-c	NOUN
admet-686	499	5	.	.	PUNCT
admet-686	500	1	tseng	tseng	PROPN
admet-686	500	2	,	,	PUNCT
admet-686	500	3	c.-y	c.-y	NOUN
admet-686	500	4	.	.	PUNCT
admet-686	501	1	lee	lee	PROPN
admet-686	501	2	,	,	PUNCT
admet-686	501	3	w.-l	w.-l	PROPN
admet-686	501	4	.	.	PUNCT
admet-686	502	1	weng	weng	PROPN
admet-686	502	2	,	,	PUNCT
admet-686	502	3	i.-m	i.-m	PROPN
admet-686	502	4	.	.	PUNCT
admet-686	502	5	shiah	shiah	PROPN
admet-686	502	6	.	.	PUNCT
admet-686	503	1	solubilities	solubility	NOUN
admet-686	503	2	of	of	ADP
admet-686	503	3	amino	amino	ADJ
admet-686	503	4	acids	acid	NOUN
admet-686	503	5	in	in	ADP
admet-686	503	6	water	water	NOUN
admet-686	503	7	at	at	ADP
admet-686	503	8	various	various	ADJ
admet-686	503	9	ph	ph	ADJ
admet-686	503	10	values	value	NOUN
admet-686	503	11	under	under	ADP
admet-686	503	12	298.15	298.15	NUM
admet-686	503	13	k.	k.	NOUN
admet-686	503	14	fluid	fluid	ADJ
admet-686	503	15	phase	phase	NOUN
admet-686	503	16	equilib	equilib	NOUN
admet-686	503	17	.	.	PUNCT
admet-686	504	1	285	285	NUM
admet-686	504	2	(	(	PUNCT
admet-686	504	3	2009	2009	NUM
admet-686	504	4	)	)	PUNCT
admet-686	504	5	90	90	NUM
admet-686	504	6	-	-	SYM
admet-686	504	7	95	95	NUM
admet-686	504	8	.	.	PUNCT
admet-686	505	1	[	[	X
admet-686	505	2	38	38	NUM
admet-686	505	3	]	]	PUNCT
admet-686	505	4	x.	x.	PROPN
admet-686	505	5	yang	yang	PROPN
admet-686	505	6	,	,	PUNCT
admet-686	505	7	x.	x.	PROPN
admet-686	505	8	wang	wang	PROPN
admet-686	505	9	,	,	PUNCT
admet-686	505	10	c.b	c.b	PROPN
admet-686	505	11	.	.	PUNCT
admet-686	505	12	ching	ching	PROPN
admet-686	505	13	.	.	PUNCT
admet-686	506	1	solubility	solubility	NOUN
admet-686	506	2	of	of	ADP
admet-686	506	3	form	form	NOUN
admet-686	506	4	alpha	alpha	NOUN
admet-686	506	5	and	and	CCONJ
admet-686	506	6	form	form	NOUN
admet-686	506	7	gamma	gamma	NOUN
admet-686	506	8	of	of	ADP
admet-686	506	9	glycine	glycine	NOUN
admet-686	506	10	in	in	ADP
admet-686	506	11	aqueous	aqueous	ADJ
admet-686	506	12	solutions	solution	NOUN
admet-686	506	13	.	.	PUNCT
admet-686	507	1	j.	j.	PROPN
admet-686	507	2	chem	chem	PROPN
admet-686	507	3	.	.	PUNCT
admet-686	508	1	eng	eng	PROPN
admet-686	508	2	.	.	PROPN
admet-686	509	1	data	data	PROPN
admet-686	509	2	53	53	NUM
admet-686	509	3	(	(	PUNCT
admet-686	509	4	2008	2008	NUM
admet-686	509	5	)	)	PUNCT
admet-686	509	6	1133	1133	NUM
admet-686	509	7	-	-	SYM
admet-686	509	8	1137	1137	NUM
admet-686	509	9	.	.	PUNCT
admet-686	510	1	[	[	X
admet-686	510	2	39	39	NUM
admet-686	510	3	]	]	X
admet-686	510	4	t.e	t.e	PROPN
admet-686	510	5	.	.	PROPN
admet-686	510	6	jr	jr	PROPN
admet-686	510	7	.	.	PUNCT
admet-686	510	8	needham	needham	PROPN
admet-686	510	9	,	,	PUNCT
admet-686	510	10	a.n	a.n	PROPN
admet-686	510	11	.	.	PROPN
admet-686	510	12	paruta	paruta	PROPN
admet-686	510	13	,	,	PUNCT
admet-686	510	14	r.j	r.j	PROPN
admet-686	510	15	.	.	PROPN
admet-686	510	16	gerraughty	gerraughty	PROPN
admet-686	510	17	.	.	PUNCT
admet-686	511	1	solubility	solubility	NOUN
admet-686	511	2	of	of	ADP
admet-686	511	3	amino	amino	ADJ
admet-686	511	4	acids	acid	NOUN
admet-686	511	5	in	in	ADP
admet-686	511	6	pure	pure	ADJ
admet-686	511	7	solvent	solvent	NOUN
admet-686	511	8	systems	system	NOUN
admet-686	511	9	.	.	PUNCT
admet-686	512	1	j.	j.	PROPN
admet-686	512	2	pharm	pharm	PROPN
admet-686	512	3	.	.	PUNCT
admet-686	513	1	sci	sci	PROPN
admet-686	513	2	.	.	PROPN
admet-686	514	1	60	60	NUM
admet-686	514	2	(	(	PUNCT
admet-686	514	3	1971	1971	NUM
admet-686	514	4	)	)	PUNCT
admet-686	514	5	565	565	NUM
admet-686	514	6	-	-	SYM
admet-686	514	7	567	567	NUM
admet-686	514	8	.	.	PUNCT
admet-686	515	1	[	[	X
admet-686	515	2	40	40	NUM
admet-686	515	3	]	]	PUNCT
admet-686	515	4	c.	c.	PROPN
admet-686	515	5	neuberg	neuberg	PROPN
admet-686	515	6	.	.	PUNCT
admet-686	516	1	hydrotropic	hydrotropic	PROPN
admet-686	516	2	phenomena	phenomena	PROPN
admet-686	516	3	.	.	PUNCT
admet-686	517	1	biochem	biochem	PROPN
admet-686	517	2	.	.	PUNCT
admet-686	518	1	z.	z.	PROPN
admet-686	518	2	76	76	NUM
admet-686	519	1	(	(	PUNCT
admet-686	519	2	1916	1916	NUM
admet-686	519	3	)	)	PUNCT
admet-686	519	4	107	107	NUM
admet-686	519	5	-	-	SYM
admet-686	519	6	176	176	NUM
admet-686	519	7	.	.	PUNCT
admet-686	520	1	[	[	X
admet-686	520	2	41	41	NUM
admet-686	520	3	]	]	X
admet-686	520	4	w.	w.	PROPN
admet-686	520	5	kunz	kunz	PROPN
admet-686	520	6	,	,	PUNCT
admet-686	520	7	k.	k.	PROPN
admet-686	520	8	holmberg	holmberg	PROPN
admet-686	520	9	,	,	PUNCT
admet-686	520	10	t.	t.	PROPN
admet-686	520	11	zemb	zemb	NOUN
admet-686	520	12	.	.	PUNCT
admet-686	521	1	hydrotropes	hydrotrope	NOUN
admet-686	521	2	.	.	PUNCT
admet-686	522	1	curr	curr	PROPN
admet-686	522	2	.	.	PUNCT
admet-686	523	1	opin	opin	NOUN
admet-686	523	2	.	.	PUNCT
admet-686	524	1	coll	coll	PROPN
admet-686	524	2	.	.	PROPN
admet-686	524	3	interf	interf	PROPN
admet-686	524	4	.	.	PUNCT
admet-686	525	1	sci	sci	PROPN
admet-686	525	2	.	.	PROPN
admet-686	526	1	22	22	NUM
admet-686	526	2	(	(	PUNCT
admet-686	526	3	2016	2016	NUM
admet-686	526	4	)	)	PUNCT
admet-686	526	5	99	99	NUM
admet-686	526	6	-	-	SYM
admet-686	526	7	107	107	NUM
admet-686	526	8	.	.	PUNCT
admet-686	527	1	[	[	X
admet-686	527	2	42	42	NUM
admet-686	527	3	]	]	SYM
admet-686	527	4	a.a	a.a	PROPN
admet-686	527	5	.	.	PROPN
admet-686	527	6	badwan	badwan	PROPN
admet-686	527	7	,	,	PUNCT
admet-686	527	8	l.k	l.k	PROPN
admet-686	527	9	.	.	PROPN
admet-686	527	10	el	el	PROPN
admet-686	527	11	-	-	PROPN
admet-686	527	12	khordagui	khordagui	PROPN
admet-686	527	13	,	,	PUNCT
admet-686	527	14	a.m.	a.m.	PROPN
admet-686	527	15	saleh	saleh	PROPN
admet-686	527	16	,	,	PUNCT
admet-686	527	17	s.a	s.a	PROPN
admet-686	527	18	.	.	PROPN
admet-686	527	19	khalil	khalil	PROPN
admet-686	527	20	.	.	PUNCT
admet-686	528	1	the	the	DET
admet-686	528	2	solubility	solubility	NOUN
admet-686	528	3	of	of	ADP
admet-686	528	4	benzodiazepines	benzodiazepine	NOUN
admet-686	528	5	in	in	ADP
admet-686	528	6	sodium	sodium	NOUN
admet-686	528	7	salicylate	salicylate	NOUN
admet-686	528	8	solution	solution	NOUN
admet-686	528	9	and	and	CCONJ
admet-686	528	10	a	a	DET
admet-686	528	11	proposed	propose	VERB
admet-686	528	12	mechanism	mechanism	NOUN
admet-686	528	13	for	for	ADP
admet-686	528	14	hydrotropic	hydrotropic	NOUN
admet-686	528	15	solubilization	solubilization	NOUN
admet-686	528	16	.	.	PUNCT
admet-686	529	1	int	int	NOUN
admet-686	529	2	.	.	PUNCT
admet-686	530	1	j.	j.	PROPN
admet-686	530	2	pharm	pharm	PROPN
admet-686	530	3	.	.	PUNCT
admet-686	531	1	13	13	NUM
admet-686	531	2	(	(	PUNCT
admet-686	531	3	1983	1983	NUM
admet-686	531	4	)	)	PUNCT
admet-686	531	5	67	67	NUM
admet-686	531	6	-	-	SYM
admet-686	531	7	74	74	NUM
admet-686	531	8	.	.	PUNCT
admet-686	532	1	bergström	bergström	NOUN
admet-686	532	2	and	and	CCONJ
admet-686	532	3	avdeef	avdeef	PROPN
admet-686	532	4	admet	admet	PROPN
admet-686	532	5	&	&	CCONJ
admet-686	532	6	dmpk	dmpk	PROPN
admet-686	532	7	7(2	7(2	NUM
admet-686	532	8	)	)	PUNCT
admet-686	532	9	(	(	PUNCT
admet-686	532	10	2019	2019	NUM
admet-686	532	11	)	)	PUNCT
admet-686	532	12	88	88	NUM
admet-686	532	13	-	-	SYM
admet-686	532	14	105	105	NUM
admet-686	532	15	104	104	NUM
admet-686	533	1	[	[	X
admet-686	533	2	43	43	NUM
admet-686	533	3	]	]	PUNCT
admet-686	533	4	t.	t.	PROPN
admet-686	533	5	parikh	parikh	PROPN
admet-686	533	6	,	,	PUNCT
admet-686	533	7	a.t.m	a.t.m	PROPN
admet-686	533	8	.	.	PUNCT
admet-686	533	9	serajuddin	serajuddin	PROPN
admet-686	533	10	.	.	PUNCT
admet-686	534	1	development	development	NOUN
admet-686	534	2	of	of	ADP
admet-686	534	3	fast	fast	ADV
admet-686	534	4	-	-	PUNCT
admet-686	534	5	dissolving	dissolve	VERB
admet-686	534	6	amorphous	amorphous	ADJ
admet-686	534	7	solid	solid	ADJ
admet-686	534	8	dispersion	dispersion	NOUN
admet-686	534	9	of	of	ADP
admet-686	534	10	itraconazole	itraconazole	NOUN
admet-686	534	11	by	by	ADP
admet-686	534	12	melt	melt	VERB
admet-686	534	13	extrusion	extrusion	NOUN
admet-686	534	14	of	of	ADP
admet-686	534	15	its	its	PRON
admet-686	534	16	mixture	mixture	NOUN
admet-686	534	17	with	with	ADP
admet-686	534	18	weak	weak	ADJ
admet-686	534	19	organic	organic	ADJ
admet-686	534	20	carboxylic	carboxylic	ADJ
admet-686	534	21	acid	acid	NOUN
admet-686	534	22	and	and	CCONJ
admet-686	534	23	polymer	polymer	NOUN
admet-686	534	24	.	.	PUNCT
admet-686	535	1	pharm	pharm	NOUN
admet-686	535	2	.	.	PUNCT
admet-686	536	1	res	re	NOUN
admet-686	536	2	.	.	PROPN
admet-686	537	1	35	35	NUM
admet-686	537	2	(	(	PUNCT
admet-686	537	3	2018	2018	NUM
admet-686	537	4	)	)	PUNCT
admet-686	537	5	127	127	NUM
admet-686	537	6	.	.	PUNCT
admet-686	538	1	in	in	ADP
admet-686	538	2	press	press	NOUN
admet-686	538	3	.	.	PUNCT
admet-686	539	1	doi	doi	NOUN
admet-686	539	2	:	:	PUNCT
admet-686	539	3	10.1007	10.1007	NUM
admet-686	539	4	/	/	SYM
admet-686	539	5	s11095	s11095	NOUN
admet-686	539	6	-	-	PUNCT
admet-686	539	7	018	018	NUM
admet-686	539	8	-	-	PUNCT
admet-686	539	9	2407	2407	NUM
admet-686	539	10	-	-	PUNCT
admet-686	539	11	4	4	NUM
admet-686	539	12	.	.	PUNCT
admet-686	540	1	[	[	X
admet-686	540	2	44	44	NUM
admet-686	540	3	]	]	PUNCT
admet-686	540	4	a.	a.	NOUN
admet-686	540	5	shah	shah	PROPN
admet-686	540	6	,	,	PUNCT
admet-686	540	7	a.t.m	a.t.m	PROPN
admet-686	540	8	.	.	PUNCT
admet-686	541	1	serajuddin	serajuddin	PROPN
admet-686	541	2	.	.	PUNCT
admet-686	542	1	conversion	conversion	NOUN
admet-686	542	2	of	of	ADP
admet-686	542	3	solid	solid	ADJ
admet-686	542	4	dispersion	dispersion	NOUN
admet-686	542	5	prepared	prepare	VERB
admet-686	542	6	by	by	ADP
admet-686	542	7	acid	acid	ADJ
admet-686	542	8	–	–	PUNCT
admet-686	542	9	base	base	NOUN
admet-686	542	10	interaction	interaction	NOUN
admet-686	542	11	into	into	ADP
admet-686	542	12	free	free	ADV
admet-686	542	13	-	-	PUNCT
admet-686	542	14	flowing	flow	VERB
admet-686	542	15	and	and	CCONJ
admet-686	542	16	tabletable	tabletable	ADJ
admet-686	542	17	powder	powder	NOUN
admet-686	542	18	by	by	ADP
admet-686	542	19	using	use	VERB
admet-686	542	20	neusilin	neusilin	PROPN
admet-686	542	21	®	®	PROPN
admet-686	542	22	us2	us2	PROPN
admet-686	542	23	.	.	PROPN
admet-686	542	24	int	int	PROPN
admet-686	542	25	.	.	PUNCT
admet-686	543	1	j.	j.	PROPN
admet-686	543	2	pharm	pharm	PROPN
admet-686	543	3	.	.	PUNCT
admet-686	544	1	484	484	NUM
admet-686	544	2	(	(	PUNCT
admet-686	544	3	2015	2015	NUM
admet-686	544	4	)	)	PUNCT
admet-686	544	5	172	172	NUM
admet-686	544	6	-	-	SYM
admet-686	544	7	180	180	NUM
admet-686	544	8	.	.	PUNCT
admet-686	545	1	[	[	X
admet-686	545	2	45	45	NUM
admet-686	545	3	]	]	PUNCT
admet-686	545	4	t.	t.	PROPN
admet-686	545	5	higuchi	higuchi	PROPN
admet-686	545	6	,	,	PUNCT
admet-686	545	7	j.l	j.l	PROPN
admet-686	545	8	.	.	PROPN
admet-686	545	9	lach	lach	PROPN
admet-686	545	10	.	.	PUNCT
admet-686	546	1	investigation	investigation	NOUN
admet-686	546	2	of	of	ADP
admet-686	546	3	some	some	DET
admet-686	546	4	complexes	complex	NOUN
admet-686	546	5	formed	form	VERB
admet-686	546	6	in	in	ADP
admet-686	546	7	solution	solution	NOUN
admet-686	546	8	by	by	ADP
admet-686	546	9	caffeine	caffeine	NOUN
admet-686	546	10	vi	vi	PROPN
admet-686	546	11	.	.	PROPN
admet-686	546	12	comparison	comparison	NOUN
admet-686	546	13	of	of	ADP
admet-686	546	14	complexing	complexe	VERB
admet-686	546	15	behaviors	behavior	NOUN
admet-686	546	16	of	of	ADP
admet-686	546	17	methylated	methylate	VERB
admet-686	546	18	xanthines	xanthine	NOUN
admet-686	546	19	with	with	ADP
admet-686	546	20	p	p	NOUN
admet-686	546	21	-	-	PUNCT
admet-686	546	22	aminobenzoic	aminobenzoic	NOUN
admet-686	546	23	acid	acid	NOUN
admet-686	546	24	,	,	PUNCT
admet-686	546	25	salicylic	salicylic	ADJ
admet-686	546	26	acid	acid	NOUN
admet-686	546	27	,	,	PUNCT
admet-686	546	28	acetylsalicylic	acetylsalicylic	NOUN
admet-686	546	29	acid	acid	NOUN
admet-686	546	30	,	,	PUNCT
admet-686	546	31	and	and	CCONJ
admet-686	546	32	p	p	ADJ
admet-686	546	33	-	-	PUNCT
admet-686	546	34	hydroxybenzoic	hydroxybenzoic	NOUN
admet-686	546	35	acid	acid	NOUN
admet-686	546	36	.	.	PUNCT
admet-686	547	1	j.	j.	PROPN
admet-686	547	2	amer	amer	PROPN
admet-686	547	3	.	.	PUNCT
admet-686	548	1	pharm	pharm	PROPN
admet-686	548	2	.	.	PUNCT
admet-686	549	1	assoc	assoc	PROPN
admet-686	549	2	.	.	PUNCT
admet-686	550	1	43	43	NUM
admet-686	550	2	(	(	PUNCT
admet-686	550	3	1954	1954	NUM
admet-686	550	4	)	)	PUNCT
admet-686	550	5	527	527	NUM
admet-686	550	6	-	-	SYM
admet-686	550	7	530	530	NUM
admet-686	550	8	.	.	PUNCT
admet-686	551	1	[	[	X
admet-686	551	2	46	46	NUM
admet-686	551	3	]	]	X
admet-686	551	4	s.l	s.l	PROPN
admet-686	551	5	.	.	PROPN
admet-686	551	6	childs	childs	PROPN
admet-686	551	7	,	,	PUNCT
admet-686	551	8	n.	n.	PROPN
admet-686	551	9	rodríguez	rodríguez	PROPN
admet-686	551	10	-	-	PUNCT
admet-686	551	11	hornedo	hornedo	PROPN
admet-686	551	12	,	,	PUNCT
admet-686	551	13	l.s	l.s	PROPN
admet-686	551	14	.	.	PROPN
admet-686	551	15	reddy	reddy	PROPN
admet-686	551	16	,	,	PUNCT
admet-686	551	17	a.	a.	NOUN
admet-686	551	18	jayasankar	jayasankar	PROPN
admet-686	551	19	,	,	PUNCT
admet-686	551	20	c.	c.	PROPN
admet-686	551	21	maheshwari	maheshwari	PROPN
admet-686	551	22	,	,	PUNCT
admet-686	551	23	l.	l.	PROPN
admet-686	551	24	mccausland	mccausland	PROPN
admet-686	551	25	,	,	PUNCT
admet-686	551	26	r.	r.	PROPN
admet-686	551	27	shipplett	shipplett	PROPN
admet-686	551	28	,	,	PUNCT
admet-686	551	29	b.c	b.c	PROPN
admet-686	551	30	.	.	PROPN
admet-686	551	31	stahly	stahly	ADV
admet-686	551	32	.	.	PUNCT
admet-686	552	1	screening	screen	VERB
admet-686	552	2	strategies	strategy	NOUN
admet-686	552	3	based	base	VERB
admet-686	552	4	on	on	ADP
admet-686	552	5	solubility	solubility	NOUN
admet-686	552	6	and	and	CCONJ
admet-686	552	7	solution	solution	NOUN
admet-686	552	8	composition	composition	NOUN
admet-686	552	9	generate	generate	VERB
admet-686	552	10	pharmaceutically	pharmaceutically	ADV
admet-686	552	11	acceptable	acceptable	ADJ
admet-686	552	12	cocrystals	cocrystal	NOUN
admet-686	552	13	of	of	ADP
admet-686	552	14	carbamazepine	carbamazepine	NOUN
admet-686	552	15	.	.	PUNCT
admet-686	553	1	cryst	cryst	PROPN
admet-686	553	2	.	.	PUNCT
admet-686	554	1	eng	eng	PROPN
admet-686	554	2	.	.	PROPN
admet-686	554	3	comm	comm	NOUN
admet-686	554	4	.	.	PUNCT
admet-686	555	1	10	10	NUM
admet-686	555	2	(	(	PUNCT
admet-686	555	3	2008	2008	NUM
admet-686	555	4	)	)	PUNCT
admet-686	555	5	856	856	NUM
admet-686	555	6	-	-	SYM
admet-686	555	7	864	864	NUM
admet-686	555	8	.	.	PUNCT
admet-686	556	1	[	[	X
admet-686	556	2	47	47	NUM
admet-686	556	3	]	]	PUNCT
admet-686	556	4	a.	a.	NOUN
admet-686	556	5	avdeef	avdeef	PROPN
admet-686	556	6	.	.	PUNCT
admet-686	557	1	cocrystal	cocrystal	PROPN
admet-686	557	2	solubility	solubility	NOUN
admet-686	557	3	product	product	NOUN
admet-686	557	4	analysis	analysis	NOUN
admet-686	557	5	–	–	PUNCT
admet-686	557	6	dual	dual	ADJ
admet-686	557	7	concentration	concentration	NOUN
admet-686	557	8	-	-	PUNCT
admet-686	557	9	ph	ph	ADJ
admet-686	557	10	mass	mass	NOUN
admet-686	557	11	action	action	NOUN
admet-686	557	12	model	model	NOUN
admet-686	557	13	not	not	PART
admet-686	557	14	dependent	dependent	ADJ
admet-686	557	15	on	on	ADP
admet-686	557	16	explicit	explicit	ADJ
admet-686	557	17	solubility	solubility	NOUN
admet-686	557	18	equations	equation	NOUN
admet-686	557	19	.	.	PUNCT
admet-686	558	1	eur	eur	PROPN
admet-686	558	2	.	.	PUNCT
admet-686	559	1	j.	j.	PROPN
admet-686	559	2	pharm	pharm	PROPN
admet-686	559	3	.	.	PUNCT
admet-686	560	1	sci	sci	PROPN
admet-686	560	2	.	.	PROPN
admet-686	561	1	110	110	NUM
admet-686	561	2	(	(	PUNCT
admet-686	561	3	2017	2017	NUM
admet-686	561	4	)	)	PUNCT
admet-686	561	5	2	2	NUM
admet-686	561	6	-	-	SYM
admet-686	561	7	18	18	NUM
admet-686	561	8	.	.	PUNCT
admet-686	562	1	[	[	X
admet-686	562	2	48	48	NUM
admet-686	562	3	]	]	PUNCT
admet-686	562	4	a.	a.	NOUN
admet-686	562	5	avdeef	avdeef	PROPN
admet-686	562	6	.	.	PUNCT
admet-686	563	1	cocrystal	cocrystal	PROPN
admet-686	563	2	solubility	solubility	NOUN
admet-686	563	3	product	product	NOUN
admet-686	563	4	prediction	prediction	NOUN
admet-686	563	5	using	use	VERB
admet-686	563	6	an	an	DET
admet-686	563	7	in	in	ADP
admet-686	563	8	combo	combo	NOUN
admet-686	563	9	model	model	NOUN
admet-686	563	10	and	and	CCONJ
admet-686	563	11	simulations	simulation	NOUN
admet-686	563	12	to	to	PART
admet-686	563	13	improve	improve	VERB
admet-686	563	14	design	design	NOUN
admet-686	563	15	of	of	ADP
admet-686	563	16	experiments	experiment	NOUN
admet-686	563	17	.	.	PUNCT
admet-686	564	1	pharm	pharm	NOUN
admet-686	564	2	.	.	PUNCT
admet-686	565	1	res	re	NOUN
admet-686	565	2	.	.	PUNCT
admet-686	566	1	(	(	PUNCT
admet-686	566	2	2018	2018	NUM
admet-686	566	3	)	)	PUNCT
admet-686	566	4	35:40	35:40	NUM
admet-686	566	5	.	.	PUNCT
admet-686	567	1	https://doi.org/10.1007/s11095-018-23433	https://doi.org/10.1007/s11095-018-23433	X
admet-686	567	2	.	.	PUNCT
admet-686	568	1	[	[	X
admet-686	568	2	49	49	NUM
admet-686	568	3	]	]	PUNCT
admet-686	568	4	a.	a.	NOUN
admet-686	568	5	alhalaweh	alhalaweh	PROPN
admet-686	568	6	,	,	PUNCT
admet-686	568	7	l.	l.	PROPN
admet-686	568	8	roy	roy	PROPN
admet-686	568	9	,	,	PUNCT
admet-686	568	10	n.	n.	PROPN
admet-686	568	11	rodríguez	rodríguez	PROPN
admet-686	568	12	-	-	PUNCT
admet-686	568	13	hornedo	hornedo	PROPN
admet-686	568	14	,	,	PUNCT
admet-686	568	15	s.p	s.p	PROPN
admet-686	568	16	.	.	PROPN
admet-686	568	17	velaga	velaga	PROPN
admet-686	568	18	.	.	PUNCT
admet-686	569	1	ph	ph	ADJ
admet-686	569	2	-	-	ADJ
admet-686	569	3	dependent	dependent	ADJ
admet-686	569	4	solubility	solubility	NOUN
admet-686	569	5	of	of	ADP
admet-686	569	6	indomethacinsaccharin	indomethacinsaccharin	NOUN
admet-686	569	7	and	and	CCONJ
admet-686	569	8	carbamazepine	carbamazepine	NOUN
admet-686	569	9	-	-	PUNCT
admet-686	569	10	saccharin	saccharin	NOUN
admet-686	569	11	cocrystals	cocrystal	NOUN
admet-686	569	12	in	in	ADP
admet-686	569	13	aqueous	aqueous	ADJ
admet-686	569	14	media	medium	NOUN
admet-686	569	15	.	.	PUNCT
admet-686	570	1	mol	mol	PROPN
admet-686	570	2	.	.	PUNCT
admet-686	571	1	pharmaceutics	pharmaceutic	NOUN
admet-686	571	2	9	9	NUM
admet-686	571	3	(	(	PUNCT
admet-686	571	4	2012	2012	NUM
admet-686	571	5	)	)	PUNCT
admet-686	571	6	2605	2605	NUM
admet-686	571	7	-	-	SYM
admet-686	571	8	2612	2612	NUM
admet-686	571	9	.	.	PUNCT
admet-686	572	1	[	[	X
admet-686	572	2	50	50	NUM
admet-686	572	3	]	]	PUNCT
admet-686	572	4	a.	a.	NOUN
admet-686	572	5	avdeef	avdeef	PROPN
admet-686	572	6	.	.	PUNCT
admet-686	573	1	suggested	suggest	VERB
admet-686	573	2	improvements	improvement	NOUN
admet-686	573	3	for	for	ADP
admet-686	573	4	measurement	measurement	NOUN
admet-686	573	5	of	of	ADP
admet-686	573	6	equilibrium	equilibrium	NOUN
admet-686	573	7	solubility	solubility	NOUN
admet-686	573	8	-	-	PUNCT
admet-686	573	9	ph	ph	NOUN
admet-686	573	10	of	of	ADP
admet-686	573	11	ionizable	ionizable	ADJ
admet-686	573	12	drugs	drug	NOUN
admet-686	573	13	.	.	PUNCT
admet-686	574	1	admet	admet	PROPN
admet-686	574	2	&	&	CCONJ
admet-686	574	3	dmpk	dmpk	PROPN
admet-686	574	4	3	3	NUM
admet-686	574	5	(	(	PUNCT
admet-686	574	6	2015	2015	NUM
admet-686	574	7	)	)	PUNCT
admet-686	574	8	84	84	NUM
admet-686	574	9	-	-	SYM
admet-686	574	10	109	109	NUM
admet-686	574	11	.	.	PUNCT
admet-686	575	1	[	[	X
admet-686	575	2	51	51	NUM
admet-686	575	3	]	]	PUNCT
admet-686	575	4	b.	b.	PROPN
admet-686	575	5	bard	bard	PROPN
admet-686	575	6	,	,	PUNCT
admet-686	575	7	s.	s.	PROPN
admet-686	575	8	martel	martel	PROPN
admet-686	575	9	,	,	PUNCT
admet-686	575	10	p.-a	p.-a	PROPN
admet-686	575	11	.	.	PUNCT
admet-686	576	1	carrupt	carrupt	PROPN
admet-686	576	2	.	.	PUNCT
admet-686	577	1	high	high	ADJ
admet-686	577	2	throughput	throughput	NOUN
admet-686	577	3	uv	uv	NOUN
admet-686	577	4	method	method	NOUN
admet-686	577	5	for	for	ADP
admet-686	577	6	the	the	DET
admet-686	577	7	estimation	estimation	NOUN
admet-686	577	8	of	of	ADP
admet-686	577	9	thermodynamic	thermodynamic	ADJ
admet-686	577	10	solubility	solubility	NOUN
admet-686	577	11	and	and	CCONJ
admet-686	577	12	the	the	DET
admet-686	577	13	determination	determination	NOUN
admet-686	577	14	of	of	ADP
admet-686	577	15	the	the	DET
admet-686	577	16	solubility	solubility	NOUN
admet-686	577	17	in	in	ADP
admet-686	577	18	biorelevant	biorelevant	ADJ
admet-686	577	19	media	medium	NOUN
admet-686	577	20	.	.	PUNCT
admet-686	578	1	eur	eur	PROPN
admet-686	578	2	.	.	PUNCT
admet-686	579	1	j.	j.	PROPN
admet-686	579	2	pharm	pharm	PROPN
admet-686	579	3	.	.	PUNCT
admet-686	580	1	sci	sci	PROPN
admet-686	580	2	.	.	PROPN
admet-686	581	1	33	33	NUM
admet-686	581	2	(	(	PUNCT
admet-686	581	3	2008	2008	NUM
admet-686	581	4	)	)	PUNCT
admet-686	581	5	230	230	NUM
admet-686	581	6	-	-	SYM
admet-686	581	7	240	240	NUM
admet-686	581	8	.	.	PUNCT
admet-686	582	1	[	[	X
admet-686	582	2	52	52	NUM
admet-686	582	3	]	]	PUNCT
admet-686	582	4	a.	a.	NOUN
admet-686	582	5	chiarini	chiarini	PROPN
admet-686	582	6	,	,	PUNCT
admet-686	582	7	a.	a.	NOUN
admet-686	582	8	tartarini	tartarini	PROPN
admet-686	582	9	,	,	PUNCT
admet-686	582	10	a.	a.	PROPN
admet-686	582	11	fini	fini	PROPN
admet-686	582	12	.	.	PUNCT
admet-686	582	13	ph	ph	ADJ
admet-686	582	14	-	-	PUNCT
admet-686	582	15	solubility	solubility	NOUN
admet-686	582	16	relationship	relationship	NOUN
admet-686	582	17	and	and	CCONJ
admet-686	582	18	partition	partition	NOUN
admet-686	582	19	coefficients	coefficient	NOUN
admet-686	582	20	for	for	ADP
admet-686	582	21	some	some	DET
admet-686	582	22	antiinflammatory	antiinflammatory	NOUN
admet-686	582	23	arylaliphatic	arylaliphatic	ADJ
admet-686	582	24	acids	acid	NOUN
admet-686	582	25	.	.	PUNCT
admet-686	583	1	arch	arch	NOUN
admet-686	583	2	.	.	PUNCT
admet-686	584	1	pharm	pharm	NOUN
admet-686	584	2	.	.	PUNCT
admet-686	585	1	(	(	PUNCT
admet-686	585	2	weinheim	weinheim	PROPN
admet-686	585	3	)	)	PUNCT
admet-686	585	4	317	317	NUM
admet-686	585	5	(	(	PUNCT
admet-686	585	6	1984	1984	NUM
admet-686	585	7	)	)	PUNCT
admet-686	585	8	268	268	NUM
admet-686	585	9	-	-	SYM
admet-686	585	10	273	273	NUM
admet-686	585	11	.	.	PUNCT
admet-686	586	1	[	[	X
admet-686	586	2	53	53	NUM
admet-686	586	3	]	]	PUNCT
admet-686	586	4	a.	a.	NOUN
admet-686	586	5	avdeef	avdeef	PROPN
admet-686	586	6	,	,	PUNCT
admet-686	586	7	c.m	c.m	PROPN
admet-686	586	8	.	.	PROPN
admet-686	586	9	berger	berger	PROPN
admet-686	586	10	,	,	PUNCT
admet-686	586	11	c.	c.	PROPN
admet-686	586	12	brownell	brownell	PROPN
admet-686	586	13	.	.	PUNCT
admet-686	587	1	ph	ph	ADJ
admet-686	587	2	-	-	ADJ
admet-686	587	3	metric	metric	ADJ
admet-686	587	4	solubility	solubility	NOUN
admet-686	587	5	.	.	PUNCT
admet-686	588	1	2	2	X
admet-686	588	2	.	.	X
admet-686	588	3	correlation	correlation	NOUN
admet-686	588	4	between	between	ADP
admet-686	588	5	the	the	DET
admet-686	588	6	acid	acid	NOUN
admet-686	588	7	-	-	PUNCT
admet-686	588	8	base	base	NOUN
admet-686	588	9	titration	titration	NOUN
admet-686	588	10	and	and	CCONJ
admet-686	588	11	the	the	DET
admet-686	588	12	saturation	saturation	NOUN
admet-686	588	13	shake	shake	NOUN
admet-686	588	14	-	-	PUNCT
admet-686	588	15	flask	flask	NOUN
admet-686	588	16	solubility	solubility	NOUN
admet-686	588	17	-	-	PUNCT
admet-686	588	18	ph	ph	ADJ
admet-686	588	19	methods	method	NOUN
admet-686	588	20	.	.	PUNCT
admet-686	589	1	pharm	pharm	NOUN
admet-686	589	2	.	.	PUNCT
admet-686	590	1	res	re	NOUN
admet-686	590	2	.	.	PROPN
admet-686	591	1	17	17	NUM
admet-686	591	2	(	(	PUNCT
admet-686	591	3	2000	2000	NUM
admet-686	591	4	)	)	PUNCT
admet-686	591	5	85	85	NUM
admet-686	591	6	-	-	SYM
admet-686	591	7	89	89	NUM
admet-686	591	8	.	.	PUNCT
admet-686	592	1	[	[	X
admet-686	592	2	54	54	NUM
admet-686	592	3	]	]	PUNCT
admet-686	592	4	a.	a.	NOUN
admet-686	592	5	fini	fini	PROPN
admet-686	592	6	,	,	PUNCT
admet-686	592	7	g.	g.	PROPN
admet-686	592	8	fazio	fazio	PROPN
admet-686	592	9	,	,	PUNCT
admet-686	592	10	g.	g.	PROPN
admet-686	592	11	feroci	feroci	PROPN
admet-686	592	12	,	,	PUNCT
admet-686	592	13	solubility	solubility	NOUN
admet-686	592	14	and	and	CCONJ
admet-686	592	15	solubilization	solubilization	NOUN
admet-686	592	16	properties	property	NOUN
admet-686	592	17	of	of	ADP
admet-686	592	18	non	non	ADJ
admet-686	592	19	-	-	ADJ
admet-686	592	20	steroidal	steroidal	ADJ
admet-686	592	21	antiinflammatory	antiinflammatory	NOUN
admet-686	592	22	drugs	drug	NOUN
admet-686	592	23	.	.	PUNCT
admet-686	593	1	int	int	NOUN
admet-686	593	2	.	.	PUNCT
admet-686	594	1	j.	j.	PROPN
admet-686	594	2	pharm	pharm	PROPN
admet-686	594	3	.	.	PUNCT
admet-686	595	1	126	126	NUM
admet-686	595	2	(	(	PUNCT
admet-686	595	3	1995	1995	NUM
admet-686	595	4	)	)	PUNCT
admet-686	595	5	95	95	NUM
admet-686	595	6	-	-	SYM
admet-686	595	7	102	102	NUM
admet-686	595	8	.	.	PUNCT
admet-686	596	1	[	[	X
admet-686	596	2	55	55	NUM
admet-686	596	3	]	]	X
admet-686	596	4	m.t	m.t	PROPN
admet-686	596	5	.	.	PROPN
admet-686	596	6	ledwidge	ledwidge	PROPN
admet-686	596	7	,	,	PUNCT
admet-686	596	8	o.i	o.i	PROPN
admet-686	596	9	.	.	PROPN
admet-686	596	10	corrigan	corrigan	PROPN
admet-686	596	11	.	.	PUNCT
admet-686	597	1	effects	effect	NOUN
admet-686	597	2	of	of	ADP
admet-686	597	3	surface	surface	NOUN
admet-686	597	4	active	active	ADJ
admet-686	597	5	characteristics	characteristic	NOUN
admet-686	597	6	and	and	CCONJ
admet-686	597	7	solid	solid	ADJ
admet-686	597	8	state	state	NOUN
admet-686	597	9	forms	form	NOUN
admet-686	597	10	on	on	ADP
admet-686	597	11	the	the	DET
admet-686	597	12	ph	ph	NOUN
admet-686	597	13	solubility	solubility	NOUN
admet-686	597	14	profiles	profile	NOUN
admet-686	597	15	of	of	ADP
admet-686	597	16	drug	drug	NOUN
admet-686	597	17	-	-	PUNCT
admet-686	597	18	salt	salt	NOUN
admet-686	597	19	systems	system	NOUN
admet-686	597	20	.	.	PUNCT
admet-686	598	1	int	int	NOUN
admet-686	598	2	.	.	PUNCT
admet-686	599	1	j.	j.	PROPN
admet-686	599	2	pharm	pharm	PROPN
admet-686	599	3	.	.	PUNCT
admet-686	600	1	174	174	NUM
admet-686	600	2	(	(	PUNCT
admet-686	600	3	1998	1998	NUM
admet-686	600	4	)	)	PUNCT
admet-686	600	5	187	187	NUM
admet-686	600	6	-	-	SYM
admet-686	600	7	200	200	NUM
admet-686	600	8	.	.	PUNCT
admet-686	601	1	[	[	X
admet-686	601	2	56	56	NUM
admet-686	601	3	]	]	X
admet-686	601	4	p.	p.	NOUN
admet-686	601	5	luger	luger	PROPN
admet-686	601	6	,	,	PUNCT
admet-686	601	7	k.	k.	PROPN
admet-686	601	8	daneck	daneck	PROPN
admet-686	601	9	,	,	PUNCT
admet-686	601	10	w.	w.	PROPN
admet-686	601	11	engel	engel	PROPN
admet-686	601	12	,	,	PUNCT
admet-686	601	13	g.	g.	PROPN
admet-686	601	14	trummlitz	trummlitz	PROPN
admet-686	601	15	.	.	PUNCT
admet-686	602	1	k.	k.	PROPN
admet-686	602	2	wagner	wagner	PROPN
admet-686	602	3	.	.	PUNCT
admet-686	603	1	structure	structure	PROPN
admet-686	603	2	and	and	CCONJ
admet-686	603	3	physicochemical	physicochemical	ADJ
admet-686	603	4	properties	property	NOUN
admet-686	603	5	of	of	ADP
admet-686	603	6	meloxicam	meloxicam	NOUN
admet-686	603	7	,	,	PUNCT
admet-686	603	8	a	a	DET
admet-686	603	9	new	new	ADJ
admet-686	603	10	nsaid	nsaid	PROPN
admet-686	603	11	.	.	PUNCT
admet-686	604	1	eur	eur	PROPN
admet-686	604	2	.	.	PUNCT
admet-686	605	1	j.	j.	PROPN
admet-686	605	2	pharm	pharm	PROPN
admet-686	605	3	.	.	PUNCT
admet-686	606	1	sci	sci	PROPN
admet-686	606	2	.	.	PROPN
admet-686	606	3	4	4	NUM
admet-686	606	4	(	(	PUNCT
admet-686	606	5	1996	1996	NUM
admet-686	606	6	)	)	PUNCT
admet-686	606	7	175	175	NUM
admet-686	606	8	-	-	SYM
admet-686	606	9	187	187	NUM
admet-686	606	10	.	.	PUNCT
admet-686	607	1	[	[	X
admet-686	607	2	57	57	NUM
admet-686	607	3	]	]	PUNCT
admet-686	607	4	l.	l.	PROPN
admet-686	607	5	zhou	zhou	PROPN
admet-686	607	6	,	,	PUNCT
admet-686	607	7	l.	l.	PROPN
admet-686	607	8	yang	yang	PROPN
admet-686	607	9	,	,	PUNCT
admet-686	607	10	s.	s.	PROPN
admet-686	607	11	tilton	tilton	PROPN
admet-686	607	12	,	,	PUNCT
admet-686	607	13	j.	j.	PROPN
admet-686	607	14	wang	wang	PROPN
admet-686	607	15	.	.	PUNCT
admet-686	608	1	development	development	NOUN
admet-686	608	2	of	of	ADP
admet-686	608	3	a	a	DET
admet-686	608	4	high	high	ADJ
admet-686	608	5	throughput	throughput	NOUN
admet-686	608	6	equilibrium	equilibrium	NOUN
admet-686	608	7	solubility	solubility	NOUN
admet-686	608	8	assay	assay	VERB
admet-686	608	9	using	use	VERB
admet-686	608	10	miniaturized	miniaturize	VERB
admet-686	608	11	shake	shake	NOUN
admet-686	608	12	-	-	PUNCT
admet-686	608	13	flask	flask	NOUN
admet-686	608	14	method	method	NOUN
admet-686	608	15	in	in	ADP
admet-686	608	16	early	early	ADJ
admet-686	608	17	drug	drug	NOUN
admet-686	608	18	discovery	discovery	NOUN
admet-686	608	19	.	.	PUNCT
admet-686	609	1	j.	j.	PROPN
admet-686	609	2	pharm	pharm	PROPN
admet-686	609	3	.	.	PUNCT
admet-686	610	1	sci	sci	PROPN
admet-686	610	2	.	.	PROPN
admet-686	611	1	96	96	NUM
admet-686	611	2	(	(	PUNCT
admet-686	611	3	2007	2007	NUM
admet-686	611	4	)	)	PUNCT
admet-686	611	5	3052	3052	NUM
admet-686	611	6	-	-	SYM
admet-686	611	7	3071	3071	NUM
admet-686	611	8	.	.	PUNCT
admet-686	612	1	[	[	X
admet-686	612	2	58	58	NUM
admet-686	612	3	]	]	X
admet-686	612	4	m.l	m.l	PROPN
admet-686	612	5	.	.	PROPN
admet-686	612	6	manca	manca	PROPN
admet-686	612	7	,	,	PUNCT
admet-686	612	8	m.	m.	PROPN
admet-686	612	9	zaru	zaru	PROPN
admet-686	612	10	,	,	PUNCT
admet-686	612	11	g.	g.	PROPN
admet-686	612	12	ennas	ennas	PROPN
admet-686	612	13	,	,	PUNCT
admet-686	612	14	d.	d.	PROPN
admet-686	612	15	valenti	valenti	PROPN
admet-686	612	16	,	,	PUNCT
admet-686	612	17	c.	c.	PROPN
admet-686	612	18	sinico	sinico	PROPN
admet-686	612	19	,	,	PUNCT
admet-686	612	20	g.	g.	PROPN
admet-686	612	21	loy	loy	PROPN
admet-686	612	22	,	,	PUNCT
admet-686	612	23	a.m.	a.m.	PROPN
admet-686	612	24	fadda	fadda	PROPN
admet-686	612	25	.	.	PUNCT
admet-686	612	26	diclofenac	diclofenac	NOUN
admet-686	612	27	-	-	PUNCT
admet-686	612	28	beta	beta	NOUN
admet-686	612	29	-	-	PUNCT
admet-686	612	30	cyclodextrin	cyclodextrin	NOUN
admet-686	612	31	binary	binary	ADJ
admet-686	612	32	systems	system	NOUN
admet-686	612	33	:	:	PUNCT
admet-686	612	34	physicochemical	physicochemical	ADJ
admet-686	612	35	characterization	characterization	NOUN
admet-686	612	36	and	and	CCONJ
admet-686	612	37	in	in	ADP
admet-686	612	38	vitro	vitro	X
admet-686	612	39	dissolution	dissolution	NOUN
admet-686	612	40	and	and	CCONJ
admet-686	612	41	diffusion	diffusion	NOUN
admet-686	612	42	studies	study	NOUN
admet-686	612	43	.	.	PUNCT
admet-686	613	1	aaps	aap	NOUN
admet-686	613	2	pharmscitech	pharmscitech	VERB
admet-686	613	3	6	6	NUM
admet-686	613	4	(	(	PUNCT
admet-686	613	5	2005	2005	NUM
admet-686	613	6	)	)	PUNCT
admet-686	613	7	e464	e464	PROPN
admet-686	613	8	-	-	PUNCT
admet-686	613	9	e472	e472	PROPN
admet-686	613	10	.	.	PUNCT
admet-686	614	1	[	[	X
admet-686	614	2	59	59	NUM
admet-686	614	3	]	]	PUNCT
admet-686	614	4	b.	b.	PROPN
admet-686	614	5	chuasuwan	chuasuwan	PROPN
admet-686	614	6	,	,	PUNCT
admet-686	614	7	v.	v.	PROPN
admet-686	614	8	binjesoh	binjesoh	PROPN
admet-686	614	9	,	,	PUNCT
admet-686	614	10	j.e	j.e	PROPN
admet-686	614	11	.	.	PROPN
admet-686	614	12	polli	polli	PROPN
admet-686	614	13	,	,	PUNCT
admet-686	614	14	h.	h.	PROPN
admet-686	614	15	zhang	zhang	PROPN
admet-686	614	16	,	,	PUNCT
admet-686	614	17	g.l	g.l	PROPN
admet-686	614	18	.	.	PROPN
admet-686	614	19	amidon	amidon	PROPN
admet-686	614	20	,	,	PUNCT
admet-686	614	21	h.e	h.e	PROPN
admet-686	614	22	.	.	PROPN
admet-686	614	23	junginger	junginger	PROPN
admet-686	614	24	,	,	PUNCT
admet-686	614	25	k.k	k.k	PROPN
admet-686	614	26	.	.	PROPN
admet-686	614	27	midha	midha	PROPN
admet-686	614	28	,	,	PUNCT
admet-686	614	29	v.p	v.p	PROPN
admet-686	614	30	.	.	PROPN
admet-686	614	31	shah	shah	PROPN
admet-686	614	32	,	,	PUNCT
admet-686	614	33	s.	s.	PROPN
admet-686	614	34	stavchansky	stavchansky	PROPN
admet-686	614	35	,	,	PUNCT
admet-686	614	36	j.b	j.b	PROPN
admet-686	614	37	.	.	PROPN
admet-686	614	38	dressman	dressman	PROPN
admet-686	614	39	,	,	PUNCT
admet-686	614	40	d.m	d.m	PROPN
admet-686	614	41	.	.	PUNCT
admet-686	614	42	barends	barends	PROPN
admet-686	614	43	.	.	PUNCT
admet-686	615	1	biowaiver	biowaiver	PROPN
admet-686	615	2	monographs	monograph	NOUN
admet-686	615	3	for	for	ADP
admet-686	615	4	immediate	immediate	ADJ
admet-686	615	5	release	release	NOUN
admet-686	615	6	solid	solid	ADJ
admet-686	615	7	oral	oral	ADJ
admet-686	615	8	dosage	dosage	NOUN
admet-686	615	9	forms	form	NOUN
admet-686	615	10	:	:	PUNCT
admet-686	615	11	diclofenac	diclofenac	NOUN
admet-686	615	12	sodium	sodium	NOUN
admet-686	615	13	and	and	CCONJ
admet-686	615	14	diclofenac	diclofenac	NOUN
admet-686	615	15	potassium	potassium	NOUN
admet-686	615	16	.	.	PUNCT
admet-686	616	1	j.	j.	PROPN
admet-686	616	2	pharm	pharm	PROPN
admet-686	616	3	.	.	PUNCT
admet-686	617	1	sci	sci	PROPN
admet-686	617	2	.	.	PROPN
admet-686	618	1	98	98	NUM
admet-686	618	2	(	(	PUNCT
admet-686	618	3	2009	2009	NUM
admet-686	618	4	)	)	PUNCT
admet-686	618	5	1206	1206	NUM
admet-686	618	6	-	-	SYM
admet-686	618	7	1219	1219	NUM
admet-686	618	8	.	.	PUNCT
admet-686	619	1	[	[	X
admet-686	619	2	60	60	NUM
admet-686	619	3	]	]	X
admet-686	619	4	c.d	c.d	PROPN
admet-686	619	5	.	.	PROPN
admet-686	619	6	herzfeldt	herzfeldt	PROPN
admet-686	619	7	,	,	PUNCT
admet-686	619	8	r.	r.	PROPN
admet-686	619	9	kuemmel	kuemmel	PROPN
admet-686	619	10	.	.	PUNCT
admet-686	620	1	dissociation	dissociation	NOUN
admet-686	620	2	constants	constant	NOUN
admet-686	620	3	,	,	PUNCT
admet-686	620	4	solubilities	solubility	NOUN
admet-686	620	5	and	and	CCONJ
admet-686	620	6	dissolution	dissolution	NOUN
admet-686	620	7	rates	rate	NOUN
admet-686	620	8	of	of	ADP
admet-686	620	9	some	some	DET
admet-686	620	10	selected	select	VERB
admet-686	620	11	nonsteroidal	nonsteroidal	NOUN
admet-686	620	12	antiinflammatories	antiinflammatorie	NOUN
admet-686	620	13	.	.	PUNCT
admet-686	621	1	drug	drug	PROPN
admet-686	621	2	dev	dev	PROPN
admet-686	621	3	.	.	PUNCT
admet-686	622	1	ind	ind	PROPN
admet-686	622	2	.	.	PUNCT
admet-686	623	1	pharm	pharm	NOUN
admet-686	623	2	.	.	PUNCT
admet-686	624	1	9	9	NUM
admet-686	624	2	(	(	PUNCT
admet-686	624	3	1983	1983	NUM
admet-686	624	4	)	)	PUNCT
admet-686	624	5	767	767	NUM
admet-686	624	6	-	-	SYM
admet-686	624	7	793	793	NUM
admet-686	624	8	.	.	PUNCT
admet-686	625	1	[	[	X
admet-686	625	2	61	61	NUM
admet-686	625	3	]	]	X
admet-686	625	4	y.	y.	NOUN
admet-686	625	5	maitani	maitani	PROPN
admet-686	625	6	,	,	PUNCT
admet-686	625	7	m.	m.	NOUN
admet-686	625	8	nakagaki	nakagaki	PROPN
admet-686	625	9	,	,	PUNCT
admet-686	625	10	t.	t.	PROPN
admet-686	625	11	nagai	nagai	PROPN
admet-686	625	12	.	.	PUNCT
admet-686	626	1	determination	determination	NOUN
admet-686	626	2	of	of	ADP
admet-686	626	3	the	the	DET
admet-686	626	4	acid	acid	PROPN
admet-686	626	5	dissociation	dissociation	NOUN
admet-686	626	6	constants	constant	NOUN
admet-686	626	7	in	in	ADP
admet-686	626	8	ethanol	ethanol	NOUN
admet-686	626	9	-	-	PUNCT
admet-686	626	10	water	water	NOUN
admet-686	626	11	mixtures	mixture	NOUN
admet-686	626	12	and	and	CCONJ
admet-686	626	13	partition	partition	NOUN
admet-686	626	14	coefficients	coefficient	NOUN
admet-686	626	15	for	for	ADP
admet-686	626	16	diclofenac	diclofenac	NOUN
admet-686	626	17	.	.	PUNCT
admet-686	627	1	int	int	NOUN
admet-686	627	2	.	.	PUNCT
admet-686	628	1	j.	j.	PROPN
admet-686	628	2	pharm	pharm	PROPN
admet-686	628	3	.	.	PUNCT
admet-686	629	1	74	74	NUM
admet-686	630	1	(	(	PUNCT
admet-686	630	2	1991	1991	NUM
admet-686	630	3	)	)	PUNCT
admet-686	630	4	105	105	NUM
admet-686	630	5	-	-	SYM
admet-686	630	6	116	116	NUM
admet-686	630	7	.	.	PUNCT
admet-686	631	1	[	[	X
admet-686	631	2	62	62	NUM
admet-686	631	3	]	]	PUNCT
admet-686	631	4	a.	a.	NOUN
admet-686	631	5	pobudkowska	pobudkowska	PROPN
admet-686	631	6	,	,	PUNCT
admet-686	631	7	u.	u.	PROPN
admet-686	631	8	domańska	domańska	PROPN
admet-686	631	9	,	,	PUNCT
admet-686	631	10	study	study	NOUN
admet-686	631	11	of	of	ADP
admet-686	631	12	ph	ph	ADJ
admet-686	631	13	-	-	ADJ
admet-686	631	14	dependent	dependent	ADJ
admet-686	631	15	drugs	drug	NOUN
admet-686	631	16	solubility	solubility	NOUN
admet-686	631	17	in	in	ADP
admet-686	631	18	water	water	NOUN
admet-686	631	19	.	.	PUNCT
admet-686	632	1	chem	chem	NOUN
admet-686	632	2	.	.	PUNCT
admet-686	633	1	ind	ind	PROPN
admet-686	633	2	.	.	PUNCT
admet-686	634	1	chem	chem	PROPN
admet-686	634	2	.	.	PUNCT
admet-686	635	1	eng	eng	PROPN
admet-686	635	2	.	.	PUNCT
admet-686	635	3	quart	quart	PROPN
admet-686	635	4	.	.	PUNCT
admet-686	636	1	20	20	NUM
admet-686	636	2	(	(	PUNCT
admet-686	636	3	2014	2014	NUM
admet-686	636	4	)	)	PUNCT
admet-686	636	5	115	115	NUM
admet-686	636	6	-	-	SYM
admet-686	636	7	126	126	NUM
admet-686	636	8	.	.	PUNCT
admet-686	637	1	admet	admet	PROPN
admet-686	637	2	&	&	CCONJ
admet-686	637	3	dmpk	dmpk	PROPN
admet-686	637	4	7(2	7(2	NUM
admet-686	637	5	)	)	PUNCT
admet-686	637	6	(	(	PUNCT
admet-686	637	7	2019	2019	NUM
admet-686	637	8	)	)	PUNCT
admet-686	637	9	88	88	NUM
admet-686	637	10	-	-	SYM
admet-686	637	11	105	105	NUM
admet-686	637	12	perspectives	perspective	NOUN
admet-686	637	13	in	in	ADP
admet-686	637	14	solubility	solubility	NOUN
admet-686	637	15	measurements	measurement	NOUN
admet-686	637	16	and	and	CCONJ
admet-686	637	17	interpretation	interpretation	NOUN
admet-686	637	18	doi	doi	PROPN
admet-686	637	19	:	:	PUNCT
admet-686	637	20	10.5599	10.5599	NUM
admet-686	637	21	/	/	SYM
admet-686	637	22	admet.686	admet.686	PRON
admet-686	637	23	105	105	NUM
admet-686	637	24	[	[	X
admet-686	637	25	63	63	NUM
admet-686	637	26	]	]	PUNCT
admet-686	637	27	w.	w.	PROPN
admet-686	637	28	riess	riess	PROPN
admet-686	637	29	,	,	PUNCT
admet-686	637	30	h.	h.	PROPN
admet-686	637	31	stierlin	stierlin	PROPN
admet-686	637	32	,	,	PUNCT
admet-686	637	33	p.	p.	NOUN
admet-686	637	34	degen	degen	PROPN
admet-686	637	35	,	,	PUNCT
admet-686	637	36	j.w	j.w	PROPN
admet-686	637	37	.	.	PROPN
admet-686	637	38	faigle	faigle	PROPN
admet-686	637	39	,	,	PUNCT
admet-686	637	40	a.	a.	NOUN
admet-686	637	41	gerardin	gerardin	PROPN
admet-686	637	42	,	,	PUNCT
admet-686	637	43	j.	j.	PROPN
admet-686	637	44	moppert	moppert	PROPN
admet-686	637	45	,	,	PUNCT
admet-686	637	46	w.	w.	PROPN
admet-686	637	47	theobald	theobald	PROPN
admet-686	637	48	,	,	PUNCT
admet-686	637	49	j.	j.	PROPN
admet-686	637	50	wagner	wagner	PROPN
admet-686	637	51	.	.	PUNCT
admet-686	637	52	pharmacokinetics	pharmacokinetic	NOUN
admet-686	637	53	and	and	CCONJ
admet-686	637	54	metabolism	metabolism	NOUN
admet-686	637	55	of	of	ADP
admet-686	637	56	the	the	DET
admet-686	637	57	anti	anti	ADJ
admet-686	637	58	-	-	ADJ
admet-686	637	59	inflammatory	inflammatory	ADJ
admet-686	637	60	agent	agent	NOUN
admet-686	637	61	voltaren	voltaren	NOUN
admet-686	637	62	.	.	PUNCT
admet-686	638	1	scand	scand	PROPN
admet-686	638	2	.	.	PUNCT
admet-686	639	1	j.	j.	PROPN
admet-686	639	2	rheumato	rheumato	PROPN
admet-686	639	3	.	.	PUNCT
admet-686	640	1	suppl	suppl	PROPN
admet-686	640	2	.	.	PUNCT
admet-686	641	1	22	22	NUM
admet-686	641	2	(	(	PUNCT
admet-686	641	3	1978	1978	NUM
admet-686	641	4	)	)	PUNCT
admet-686	641	5	17	17	NUM
admet-686	641	6	-	-	SYM
admet-686	641	7	29	29	NUM
admet-686	641	8	.	.	PUNCT
admet-686	642	1	[	[	X
admet-686	642	2	64	64	NUM
admet-686	642	3	]	]	PUNCT
admet-686	642	4	g.	g.	PROPN
admet-686	642	5	völgyi	völgyi	PROPN
admet-686	642	6	,	,	PUNCT
admet-686	642	7	d.	d.	PROPN
admet-686	642	8	csicsák	csicsák	PROPN
admet-686	642	9	,	,	PUNCT
admet-686	642	10	k.	k.	PROPN
admet-686	642	11	takács	takács	PROPN
admet-686	642	12	-	-	PUNCT
admet-686	642	13	novák	novák	PROPN
admet-686	642	14	.	.	PUNCT
admet-686	643	1	right	right	ADJ
admet-686	643	2	filter	filter	NOUN
admet-686	643	3	-	-	PUNCT
admet-686	643	4	selection	selection	NOUN
admet-686	643	5	for	for	ADP
admet-686	643	6	phase	phase	NOUN
admet-686	643	7	separation	separation	NOUN
admet-686	643	8	in	in	ADP
admet-686	643	9	equilibrium	equilibrium	NOUN
admet-686	643	10	solubility	solubility	NOUN
admet-686	643	11	measurement	measurement	NOUN
admet-686	643	12	.	.	PUNCT
admet-686	644	1	eur	eur	PROPN
admet-686	644	2	.	.	PUNCT
admet-686	645	1	j.	j.	PROPN
admet-686	645	2	pharm	pharm	PROPN
admet-686	645	3	.	.	PUNCT
admet-686	646	1	sci	sci	PROPN
admet-686	646	2	.	.	PROPN
admet-686	647	1	123	123	NUM
admet-686	647	2	(	(	PUNCT
admet-686	647	3	2018	2018	NUM
admet-686	647	4	)	)	PUNCT
admet-686	647	5	98	98	NUM
admet-686	647	6	-	-	SYM
admet-686	647	7	105	105	NUM
admet-686	647	8	.	.	PUNCT
admet-686	648	1	[	[	X
admet-686	648	2	65	65	NUM
admet-686	648	3	]	]	X
admet-686	648	4	a.	a.	NOUN
admet-686	648	5	llinàs	llinàs	PROPN
admet-686	648	6	,	,	PUNCT
admet-686	648	7	r.c	r.c	PROPN
admet-686	648	8	.	.	PROPN
admet-686	648	9	glen	glen	PROPN
admet-686	648	10	,	,	PUNCT
admet-686	648	11	j.m	j.m	PROPN
admet-686	648	12	.	.	PROPN
admet-686	648	13	goodman	goodman	PROPN
admet-686	648	14	,	,	PUNCT
admet-686	648	15	solubility	solubility	NOUN
admet-686	648	16	challenge	challenge	NOUN
admet-686	648	17	:	:	PUNCT
admet-686	648	18	can	can	AUX
admet-686	648	19	you	you	PRON
admet-686	648	20	predict	predict	VERB
admet-686	648	21	solubilities	solubility	NOUN
admet-686	648	22	of	of	ADP
admet-686	648	23	32	32	NUM
admet-686	648	24	molecules	molecule	NOUN
admet-686	648	25	using	use	VERB
admet-686	648	26	a	a	DET
admet-686	648	27	database	database	NOUN
admet-686	648	28	of	of	ADP
admet-686	648	29	100	100	NUM
admet-686	648	30	reliable	reliable	ADJ
admet-686	648	31	measurements	measurement	NOUN
admet-686	648	32	?	?	PUNCT
admet-686	648	33	.	.	PUNCT
admet-686	649	1	j.	j.	PROPN
admet-686	649	2	chem	chem	PROPN
admet-686	649	3	.	.	PUNCT
admet-686	650	1	inf	inf	PROPN
admet-686	650	2	.	.	PROPN
admet-686	650	3	model	model	PROPN
admet-686	650	4	.	.	PUNCT
admet-686	651	1	48	48	NUM
admet-686	651	2	(	(	PUNCT
admet-686	651	3	2008	2008	NUM
admet-686	651	4	)	)	PUNCT
admet-686	651	5	1289	1289	NUM
admet-686	651	6	-	-	SYM
admet-686	651	7	1303	1303	NUM
admet-686	651	8	.	.	PUNCT
admet-686	652	1	[	[	X
admet-686	652	2	66	66	NUM
admet-686	652	3	]	]	X
admet-686	652	4	a.j	a.j	PROPN
admet-686	652	5	.	.	PROPN
admet-686	652	6	hopfinger	hopfinger	PROPN
admet-686	652	7	,	,	PUNCT
admet-686	652	8	e.x	e.x	PROPN
admet-686	652	9	.	.	PROPN
admet-686	652	10	esposito	esposito	PROPN
admet-686	652	11	,	,	PUNCT
admet-686	652	12	a.	a.	PROPN
admet-686	652	13	llinàs	llinàs	PROPN
admet-686	652	14	,	,	PUNCT
admet-686	652	15	r.c	r.c	PROPN
admet-686	652	16	.	.	PROPN
admet-686	652	17	glen	glen	PROPN
admet-686	652	18	,	,	PUNCT
admet-686	652	19	j.m	j.m	PROPN
admet-686	652	20	.	.	PROPN
admet-686	652	21	goodman	goodman	PROPN
admet-686	652	22	.	.	PUNCT
admet-686	653	1	findings	finding	NOUN
admet-686	653	2	of	of	ADP
admet-686	653	3	the	the	DET
admet-686	653	4	challenge	challenge	NOUN
admet-686	653	5	to	to	PART
admet-686	653	6	predict	predict	VERB
admet-686	653	7	aqueous	aqueous	ADJ
admet-686	653	8	solubility	solubility	NOUN
admet-686	653	9	.	.	PUNCT
admet-686	654	1	j.	j.	PROPN
admet-686	654	2	chem	chem	PROPN
admet-686	654	3	.	.	PUNCT
admet-686	655	1	inf	inf	PROPN
admet-686	655	2	.	.	PROPN
admet-686	655	3	model	model	PROPN
admet-686	655	4	.	.	PUNCT
admet-686	656	1	49	49	NUM
admet-686	656	2	(	(	PUNCT
admet-686	656	3	2009	2009	NUM
admet-686	656	4	)	)	PUNCT
admet-686	656	5	1	1	NUM
admet-686	656	6	-	-	SYM
admet-686	656	7	5	5	NUM
admet-686	656	8	.	.	PUNCT
admet-686	657	1	[	[	X
admet-686	657	2	67	67	NUM
admet-686	657	3	]	]	X
admet-686	657	4	j.h	j.h	PROPN
admet-686	657	5	.	.	PROPN
admet-686	657	6	fagerberg	fagerberg	PROPN
admet-686	657	7	,	,	PUNCT
admet-686	657	8	e.	e.	PROPN
admet-686	657	9	karlsson	karlsson	PROPN
admet-686	657	10	,	,	PUNCT
admet-686	657	11	j.	j.	PROPN
admet-686	657	12	ulander	ulander	PROPN
admet-686	657	13	,	,	PUNCT
admet-686	657	14	g.	g.	PROPN
admet-686	657	15	hanisch	hanisch	PROPN
admet-686	657	16	,	,	PUNCT
admet-686	657	17	c.a.s	c.a.	VERB
admet-686	657	18	.	.	PROPN
admet-686	657	19	bergström	bergström	NOUN
admet-686	657	20	.	.	PUNCT
admet-686	658	1	computational	computational	ADJ
admet-686	658	2	prediction	prediction	NOUN
admet-686	658	3	of	of	ADP
admet-686	658	4	drug	drug	NOUN
admet-686	658	5	solubility	solubility	NOUN
admet-686	658	6	in	in	ADP
admet-686	658	7	fasted	fast	VERB
admet-686	658	8	simulated	simulate	VERB
admet-686	658	9	and	and	CCONJ
admet-686	658	10	aspirated	aspirate	VERB
admet-686	658	11	human	human	ADJ
admet-686	658	12	intestinal	intestinal	ADJ
admet-686	658	13	fluid	fluid	NOUN
admet-686	658	14	.	.	PUNCT
admet-686	659	1	pharm	pharm	NOUN
admet-686	659	2	.	.	PUNCT
admet-686	660	1	res	re	NOUN
admet-686	660	2	.	.	PUNCT
admet-686	661	1	32	32	NUM
admet-686	661	2	(	(	PUNCT
admet-686	661	3	2015	2015	NUM
admet-686	661	4	)	)	PUNCT
admet-686	661	5	578589	578589	NUM
admet-686	661	6	.	.	PUNCT
admet-686	662	1	©	©	NOUN
admet-686	662	2	2019	2019	NUM
admet-686	662	3	by	by	ADP
admet-686	662	4	the	the	DET
admet-686	662	5	authors	author	NOUN
admet-686	662	6	;	;	PUNCT
admet-686	662	7	licensee	licensee	PROPN
admet-686	662	8	iapc	iapc	PROPN
admet-686	662	9	,	,	PUNCT
admet-686	662	10	zagreb	zagreb	PROPN
admet-686	662	11	,	,	PUNCT
admet-686	662	12	croatia	croatia	PROPN
admet-686	662	13	.	.	PUNCT
admet-686	663	1	this	this	DET
admet-686	663	2	article	article	NOUN
admet-686	663	3	is	be	AUX
admet-686	663	4	an	an	DET
admet-686	663	5	open	open	ADJ
admet-686	663	6	-	-	PUNCT
admet-686	663	7	access	access	NOUN
admet-686	663	8	article	article	NOUN
admet-686	663	9	distributed	distribute	VERB
admet-686	663	10	under	under	ADP
admet-686	663	11	the	the	DET
admet-686	663	12	terms	term	NOUN
admet-686	663	13	and	and	CCONJ
admet-686	663	14	conditions	condition	NOUN
admet-686	663	15	of	of	ADP
admet-686	663	16	the	the	DET
admet-686	663	17	creative	creative	ADJ
admet-686	663	18	commons	common	NOUN
admet-686	663	19	attribution	attribution	NOUN
admet-686	663	20	license	license	NOUN
admet-686	663	21	(	(	PUNCT
admet-686	663	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-686	663	23	)	)	PUNCT
admet-686	663	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN