id	sid	tid	token	lemma	pos
admet-704	1	1	harmonizing	harmonize	VERB
admet-704	1	2	solubility	solubility	NOUN
admet-704	1	3	measurement	measurement	NOUN
admet-704	1	4	to	to	PART
admet-704	1	5	lower	lower	VERB
admet-704	1	6	inter	inter	ADJ
admet-704	1	7	-	-	ADJ
admet-704	1	8	laboratory	laboratory	ADJ
admet-704	1	9	variance	variance	NOUN
admet-704	1	10	–	–	PUNCT
admet-704	1	11	progress	progress	NOUN
admet-704	1	12	of	of	ADP
admet-704	1	13	consortium	consortium	NOUN
admet-704	1	14	of	of	ADP
admet-704	1	15	biopharmaceutical	biopharmaceutical	ADJ
admet-704	1	16	tools	tool	NOUN
admet-704	1	17	(	(	PUNCT
admet-704	1	18	cobito	cobito	ADJ
admet-704	1	19	)	)	PUNCT
admet-704	1	20	in	in	ADP
admet-704	1	21	japan	japan	PROPN
admet-704	1	22	doi	doi	PROPN
admet-704	1	23	:	:	PUNCT
admet-704	1	24	10.5599	10.5599	NUM
admet-704	1	25	/	/	SYM
admet-704	1	26	admet.704	admet.704	ADJ
admet-704	1	27	183	183	NUM
admet-704	1	28	admet	admet	X
admet-704	1	29	&	&	CCONJ
admet-704	1	30	dmpk	dmpk	PROPN
admet-704	1	31	7(3	7(3	NUM
admet-704	1	32	)	)	PUNCT
admet-704	1	33	(	(	PUNCT
admet-704	1	34	2019)183	2019)183	NUM
admet-704	1	35	-	-	PUNCT
admet-704	1	36	195	195	NUM
admet-704	1	37	;	;	PUNCT
admet-704	1	38	doi	doi	NOUN
admet-704	1	39	:	:	PUNCT
admet-704	1	40	http://dx.doi.org/10.5599/admet.704	http://dx.doi.org/10.5599/admet.704	X
admet-704	1	41	open	open	ADJ
admet-704	1	42	access	access	NOUN
admet-704	1	43	:	:	PUNCT
admet-704	1	44	issn	issn	PROPN
admet-704	1	45	:	:	PUNCT
admet-704	1	46	1848	1848	NUM
admet-704	1	47	-	-	SYM
admet-704	1	48	7718	7718	NUM
admet-704	1	49	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-704	1	50	original	original	ADJ
admet-704	1	51	scientific	scientific	ADJ
admet-704	1	52	paper	paper	NOUN
admet-704	1	53	harmonizing	harmonize	VERB
admet-704	1	54	solubility	solubility	NOUN
admet-704	1	55	measurement	measurement	NOUN
admet-704	1	56	to	to	PART
admet-704	1	57	lower	lower	VERB
admet-704	1	58	inter	inter	ADJ
admet-704	1	59	-	-	ADJ
admet-704	1	60	laboratory	laboratory	ADJ
admet-704	1	61	variance	variance	NOUN
admet-704	1	62	–	–	PUNCT
admet-704	1	63	progress	progress	NOUN
admet-704	1	64	of	of	ADP
admet-704	1	65	consortium	consortium	NOUN
admet-704	1	66	of	of	ADP
admet-704	1	67	biopharmaceutical	biopharmaceutical	ADJ
admet-704	1	68	tools	tool	NOUN
admet-704	1	69	(	(	PUNCT
admet-704	1	70	cobito	cobito	ADJ
admet-704	1	71	)	)	PUNCT
admet-704	1	72	in	in	ADP
admet-704	1	73	japan	japan	PROPN
admet-704	1	74	asami	asami	PROPN
admet-704	1	75	ono	ono	PROPN
admet-704	1	76	1	1	NUM
admet-704	1	77	,	,	PUNCT
admet-704	1	78	*	*	PUNCT
admet-704	1	79	,	,	PUNCT
admet-704	1	80	naoya	naoya	ADV
admet-704	1	81	matsumura	matsumura	ADJ
admet-704	1	82	2	2	NUM
admet-704	1	83	,	,	PUNCT
admet-704	1	84	takahiro	takahiro	PROPN
admet-704	1	85	kimoto	kimoto	PROPN
admet-704	1	86	3	3	AUX
admet-704	1	87	,	,	PUNCT
admet-704	1	88	yoshiyuki	yoshiyuki	PROPN
admet-704	1	89	akiyama	akiyama	PROPN
admet-704	1	90	3	3	NUM
admet-704	1	91	,	,	PUNCT
admet-704	1	92	satoko	satoko	X
admet-704	1	93	funaki	funaki	ADV
admet-704	1	94	4	4	NUM
admet-704	1	95	,	,	PUNCT
admet-704	1	96	naomi	naomi	PROPN
admet-704	1	97	tamura	tamura	PROPN
admet-704	1	98	4	4	NUM
admet-704	1	99	,	,	PUNCT
admet-704	1	100	shun	shun	PROPN
admet-704	1	101	hayashi	hayashi	PROPN
admet-704	1	102	5	5	NUM
admet-704	1	103	,	,	PUNCT
admet-704	1	104	yukiko	yukiko	PROPN
admet-704	1	105	kojima	kojima	PROPN
admet-704	1	106	6	6	NUM
admet-704	1	107	,	,	PUNCT
admet-704	1	108	masahiro	masahiro	PROPN
admet-704	1	109	fushimi	fushimi	PROPN
admet-704	1	110	6	6	NUM
admet-704	1	111	,	,	PUNCT
admet-704	1	112	hiroshi	hiroshi	PROPN
admet-704	1	113	sudaki	sudaki	PROPN
admet-704	1	114	7	7	NUM
admet-704	1	115	,	,	PUNCT
admet-704	1	116	risa	risa	PROPN
admet-704	1	117	aihara	aihara	NOUN
admet-704	1	118	7	7	NUM
admet-704	1	119	,	,	PUNCT
admet-704	1	120	yuka	yuka	PROPN
admet-704	1	121	haruna	haruna	PROPN
admet-704	1	122	8	8	NUM
admet-704	1	123	,	,	PUNCT
admet-704	1	124	maiko	maiko	NOUN
admet-704	1	125	jiko	jiko	PROPN
admet-704	1	126	8	8	NUM
admet-704	1	127	,	,	PUNCT
admet-704	1	128	masaru	masaru	PROPN
admet-704	1	129	iwasaki	iwasaki	PROPN
admet-704	1	130	9	9	NUM
admet-704	1	131	,	,	PUNCT
admet-704	1	132	takuya	takuya	PROPN
admet-704	1	133	fujita	fujita	PROPN
admet-704	1	134	10	10	NUM
admet-704	1	135	and	and	CCONJ
admet-704	1	136	kiyohiko	kiyohiko	VERB
admet-704	1	137	sugano	sugano	VERB
admet-704	1	138	10	10	NUM
admet-704	1	139	1	1	NUM
admet-704	1	140	asahi	asahi	NOUN
admet-704	1	141	kasei	kasei	PROPN
admet-704	1	142	pharma	pharma	PROPN
admet-704	1	143	corporation	corporation	NOUN
admet-704	1	144	,	,	PUNCT
admet-704	1	145	632	632	NUM
admet-704	1	146	-	-	SYM
admet-704	1	147	1	1	NUM
admet-704	1	148	mifuku	mifuku	NOUN
admet-704	1	149	,	,	PUNCT
admet-704	1	150	izunokuni	izunokuni	PROPN
admet-704	1	151	,	,	PUNCT
admet-704	1	152	shizuoka	shizuoka	PROPN
admet-704	1	153	410	410	NUM
admet-704	1	154	-	-	SYM
admet-704	1	155	2321	2321	NUM
admet-704	1	156	,	,	PUNCT
admet-704	1	157	japan	japan	PROPN
admet-704	1	158	2	2	NUM
admet-704	1	159	ono	ono	PROPN
admet-704	1	160	pharmaceutical	pharmaceutical	PROPN
admet-704	1	161	co.	co.	PROPN
admet-704	1	162	,	,	PUNCT
admet-704	1	163	ltd	ltd	PROPN
admet-704	1	164	.	.	PROPN
admet-704	1	165	,	,	PUNCT
admet-704	1	166	3	3	NUM
admet-704	1	167	-	-	SYM
admet-704	1	168	3	3	NUM
admet-704	1	169	-	-	SYM
admet-704	1	170	1	1	NUM
admet-704	1	171	,	,	PUNCT
admet-704	1	172	sakurai	sakurai	NOUN
admet-704	1	173	,	,	PUNCT
admet-704	1	174	shimamoto	shimamoto	NOUN
admet-704	1	175	-	-	PUNCT
admet-704	1	176	cho	cho	PROPN
admet-704	1	177	,	,	PUNCT
admet-704	1	178	mishima	mishima	NOUN
admet-704	1	179	-	-	PUNCT
admet-704	1	180	gun	gun	PROPN
admet-704	1	181	,	,	PUNCT
admet-704	1	182	osaka	osaka	PROPN
admet-704	1	183	618	618	NUM
admet-704	1	184	-	-	SYM
admet-704	1	185	8585	8585	NUM
admet-704	1	186	,	,	PUNCT
admet-704	1	187	japan	japan	PROPN
admet-704	1	188	3	3	NUM
admet-704	1	189	central	central	ADJ
admet-704	1	190	pharmaceutical	pharmaceutical	PROPN
admet-704	1	191	research	research	PROPN
admet-704	1	192	institute	institute	PROPN
admet-704	1	193	,	,	PUNCT
admet-704	1	194	japan	japan	PROPN
admet-704	1	195	tobacco	tobacco	PROPN
admet-704	1	196	inc	inc	PROPN
admet-704	1	197	,	,	PUNCT
admet-704	1	198	1	1	NUM
admet-704	1	199	-	-	SYM
admet-704	1	200	1	1	NUM
admet-704	1	201	murasaki	murasaki	PROPN
admet-704	1	202	-	-	PUNCT
admet-704	1	203	cho	cho	PROPN
admet-704	1	204	,	,	PUNCT
admet-704	1	205	takatsuki	takatsuki	PROPN
admet-704	1	206	,	,	PUNCT
admet-704	1	207	osaka	osaka	PROPN
admet-704	1	208	569	569	NUM
admet-704	1	209	-	-	SYM
admet-704	1	210	1125	1125	NUM
admet-704	1	211	,	,	PUNCT
admet-704	1	212	japan	japan	PROPN
admet-704	1	213	4	4	NUM
admet-704	1	214	shionogi	shionogi	PROPN
admet-704	1	215	&	&	CCONJ
admet-704	1	216	co.	co.	PROPN
admet-704	1	217	,	,	PUNCT
admet-704	1	218	ltd	ltd	PROPN
admet-704	1	219	.	.	PROPN
admet-704	1	220	,	,	PUNCT
admet-704	1	221	3	3	NUM
admet-704	1	222	-	-	SYM
admet-704	1	223	1	1	NUM
admet-704	1	224	-	-	SYM
admet-704	1	225	1	1	NUM
admet-704	1	226	,	,	PUNCT
admet-704	1	227	futaba	futaba	PROPN
admet-704	1	228	-	-	PUNCT
admet-704	1	229	cho	cho	PROPN
admet-704	1	230	,	,	PUNCT
admet-704	1	231	toyonaka	toyonaka	PROPN
admet-704	1	232	-	-	PUNCT
admet-704	1	233	shi	shi	PROPN
admet-704	1	234	,	,	PUNCT
admet-704	1	235	osaka	osaka	PROPN
admet-704	1	236	561	561	NUM
admet-704	1	237	-	-	SYM
admet-704	1	238	0825	0825	NUM
admet-704	1	239	,	,	PUNCT
admet-704	1	240	japan	japan	PROPN
admet-704	1	241	5	5	NUM
admet-704	1	242	sumitomo	sumitomo	PROPN
admet-704	1	243	dainippon	dainippon	PROPN
admet-704	1	244	pharma	pharma	PROPN
admet-704	1	245	co.	co.	PROPN
admet-704	1	246	,	,	PUNCT
admet-704	1	247	ltd	ltd	PROPN
admet-704	1	248	.	.	PROPN
admet-704	1	249	,	,	PUNCT
admet-704	1	250	3	3	NUM
admet-704	1	251	-	-	SYM
admet-704	1	252	1	1	NUM
admet-704	1	253	-	-	SYM
admet-704	1	254	98	98	NUM
admet-704	1	255	kasugadenaka	kasugadenaka	NOUN
admet-704	1	256	,	,	PUNCT
admet-704	1	257	konohana	konohana	PROPN
admet-704	1	258	-	-	PUNCT
admet-704	1	259	ku	ku	PROPN
admet-704	1	260	,	,	PUNCT
admet-704	1	261	osaka	osaka	PROPN
admet-704	1	262	554	554	NUM
admet-704	1	263	-	-	SYM
admet-704	1	264	0022	0022	NUM
admet-704	1	265	,	,	PUNCT
admet-704	1	266	japan	japan	PROPN
admet-704	1	267	6	6	NUM
admet-704	1	268	sawai	sawai	PROPN
admet-704	1	269	pharmaceutical	pharmaceutical	PROPN
admet-704	1	270	co.	co.	PROPN
admet-704	1	271	,	,	PUNCT
admet-704	1	272	ltd	ltd	PROPN
admet-704	1	273	.	.	PROPN
admet-704	1	274	,	,	PUNCT
admet-704	1	275	5	5	NUM
admet-704	1	276	-	-	SYM
admet-704	1	277	2	2	NUM
admet-704	1	278	-	-	SYM
admet-704	1	279	30	30	NUM
admet-704	1	280	,	,	PUNCT
admet-704	1	281	miyahara	miyahara	PROPN
admet-704	1	282	,	,	PUNCT
admet-704	1	283	yodogawa	yodogawa	PROPN
admet-704	1	284	-	-	PUNCT
admet-704	1	285	ku	ku	PROPN
admet-704	1	286	,	,	PUNCT
admet-704	1	287	osaka	osaka	PROPN
admet-704	1	288	532	532	NUM
admet-704	1	289	-	-	SYM
admet-704	1	290	0003	0003	NUM
admet-704	1	291	,	,	PUNCT
admet-704	1	292	japan	japan	PROPN
admet-704	1	293	7	7	NUM
admet-704	2	1	nippon	nippon	PROPN
admet-704	2	2	boehringer	boehringer	PROPN
admet-704	2	3	ingelheim	ingelheim	PROPN
admet-704	2	4	co.	co.	PROPN
admet-704	2	5	ltd	ltd	PROPN
admet-704	2	6	.	.	PROPN
admet-704	2	7	,	,	PUNCT
admet-704	2	8	6	6	NUM
admet-704	2	9	-	-	SYM
admet-704	2	10	7	7	NUM
admet-704	2	11	-	-	SYM
admet-704	2	12	5	5	NUM
admet-704	2	13	minatojima	minatojima	NOUN
admet-704	2	14	-	-	PUNCT
admet-704	2	15	minamimachi	minamimachi	NOUN
admet-704	2	16	,	,	PUNCT
admet-704	2	17	chuo	chuo	NOUN
admet-704	2	18	-	-	PUNCT
admet-704	2	19	ku	ku	PROPN
admet-704	2	20	,	,	PUNCT
admet-704	2	21	kobe	kobe	PROPN
admet-704	2	22	,	,	PUNCT
admet-704	2	23	hyogo	hyogo	VERB
admet-704	2	24	650	650	NUM
admet-704	2	25	-	-	PUNCT
admet-704	2	26	0047	0047	NUM
admet-704	2	27	,	,	PUNCT
admet-704	2	28	japan	japan	PROPN
admet-704	2	29	8	8	NUM
admet-704	2	30	towa	towa	PROPN
admet-704	2	31	pharmaceutical	pharmaceutical	PROPN
admet-704	2	32	co.	co.	PROPN
admet-704	2	33	,	,	PUNCT
admet-704	2	34	ltd	ltd	PROPN
admet-704	2	35	.	.	PROPN
admet-704	2	36	,	,	PUNCT
admet-704	2	37	134	134	NUM
admet-704	2	38	chudoji	chudoji	PROPN
admet-704	2	39	minami	minami	PROPN
admet-704	2	40	-	-	PUNCT
admet-704	2	41	machi	machi	PROPN
admet-704	2	42	,	,	PUNCT
admet-704	2	43	shimogyo	shimogyo	NOUN
admet-704	2	44	-	-	PUNCT
admet-704	2	45	ku	ku	NOUN
admet-704	2	46	,	,	PUNCT
admet-704	2	47	kyoto	kyoto	PROPN
admet-704	2	48	600	600	NUM
admet-704	2	49	-	-	SYM
admet-704	2	50	8813	8813	NUM
admet-704	2	51	,	,	PUNCT
admet-704	2	52	japan	japan	PROPN
admet-704	2	53	9	9	NUM
admet-704	2	54	daiichi	daiichi	PROPN
admet-704	2	55	sankyo	sankyo	PROPN
admet-704	2	56	rd	rd	PROPN
admet-704	2	57	novare	novare	PROPN
admet-704	2	58	co.	co.	PROPN
admet-704	2	59	,	,	PUNCT
admet-704	2	60	ltd	ltd	PROPN
admet-704	2	61	,	,	PUNCT
admet-704	2	62	1	1	NUM
admet-704	2	63	-	-	SYM
admet-704	2	64	16	16	NUM
admet-704	2	65	-	-	SYM
admet-704	2	66	13	13	NUM
admet-704	2	67	kitakasai	kitakasai	NOUN
admet-704	2	68	,	,	PUNCT
admet-704	2	69	edogawa	edogawa	PROPN
admet-704	2	70	-	-	PUNCT
admet-704	2	71	ku	ku	PROPN
admet-704	2	72	,	,	PUNCT
admet-704	2	73	tokyo	tokyo	PROPN
admet-704	2	74	134	134	NUM
admet-704	2	75	-	-	SYM
admet-704	2	76	8630	8630	NUM
admet-704	2	77	,	,	PUNCT
admet-704	2	78	japan	japan	PROPN
admet-704	2	79	10	10	NUM
admet-704	2	80	college	college	PROPN
admet-704	2	81	of	of	ADP
admet-704	2	82	pharmaceutical	pharmaceutical	NOUN
admet-704	2	83	sciences	science	NOUN
admet-704	2	84	,	,	PUNCT
admet-704	2	85	ritsumeikan	ritsumeikan	ADJ
admet-704	2	86	university	university	NOUN
admet-704	2	87	,	,	PUNCT
admet-704	2	88	1	1	NUM
admet-704	2	89	-	-	SYM
admet-704	2	90	1	1	NUM
admet-704	2	91	-	-	SYM
admet-704	2	92	1	1	NUM
admet-704	2	93	noji	noji	NOUN
admet-704	2	94	-	-	PUNCT
admet-704	2	95	higashi	higashi	PROPN
admet-704	2	96	,	,	PUNCT
admet-704	2	97	kusatsu	kusatsu	NOUN
admet-704	2	98	,	,	PUNCT
admet-704	2	99	shiga	shiga	NOUN
admet-704	2	100	525	525	NUM
admet-704	2	101	-	-	SYM
admet-704	2	102	8577	8577	NUM
admet-704	2	103	,	,	PUNCT
admet-704	2	104	japan	japan	PROPN
admet-704	2	105	*	*	PUNCT
admet-704	2	106	corresponding	correspond	VERB
admet-704	2	107	author	author	NOUN
admet-704	2	108	:	:	PUNCT
admet-704	2	109	e	e	NOUN
admet-704	2	110	-	-	NOUN
admet-704	2	111	mail	mail	NOUN
admet-704	2	112	:	:	PUNCT
admet-704	2	113	ono.ar@om.asahi-kasei.co.jp	ono.ar@om.asahi-kasei.co.jp	NUM
admet-704	2	114	;	;	PUNCT
admet-704	2	115	tel	tel	PROPN
admet-704	2	116	.	.	PROPN
admet-704	2	117	:	:	PUNCT
admet-704	3	1	+81	+81	NUM
admet-704	3	2	-	-	PUNCT
admet-704	3	3	558	558	NUM
admet-704	3	4	-	-	PUNCT
admet-704	3	5	76	76	NUM
admet-704	3	6	-	-	PUNCT
admet-704	3	7	7061	7061	NUM
admet-704	3	8	;	;	PUNCT
admet-704	3	9	fax	fax	NOUN
admet-704	3	10	:	:	PUNCT
admet-704	3	11	+81	+81	ADJ
admet-704	3	12	-	-	PUNCT
admet-704	3	13	558	558	NUM
admet-704	3	14	-	-	PUNCT
admet-704	3	15	76	76	NUM
admet-704	3	16	-	-	PUNCT
admet-704	3	17	7137	7137	NUM
admet-704	3	18	received	receive	VERB
admet-704	3	19	:	:	PUNCT
admet-704	3	20	june	june	PROPN
admet-704	3	21	12	12	NUM
admet-704	3	22	,	,	PUNCT
admet-704	3	23	2019	2019	NUM
admet-704	3	24	;	;	PUNCT
admet-704	3	25	revised	revise	VERB
admet-704	3	26	:	:	PUNCT
admet-704	3	27	july	july	PROPN
admet-704	3	28	19	19	NUM
admet-704	3	29	,	,	PUNCT
admet-704	3	30	2019	2019	NUM
admet-704	3	31	;	;	PUNCT
admet-704	3	32	available	available	ADJ
admet-704	3	33	online	online	NOUN
admet-704	3	34	:	:	PUNCT
admet-704	3	35	august	august	PROPN
admet-704	3	36	05	05	NUM
admet-704	3	37	,	,	PUNCT
admet-704	3	38	2019	2019	NUM
admet-704	3	39	abstract	abstract	NOUN
admet-704	3	40	the	the	DET
admet-704	3	41	purpose	purpose	NOUN
admet-704	3	42	of	of	ADP
admet-704	3	43	the	the	DET
admet-704	3	44	present	present	ADJ
admet-704	3	45	study	study	NOUN
admet-704	3	46	was	be	AUX
admet-704	3	47	to	to	PART
admet-704	3	48	harmonize	harmonize	VERB
admet-704	3	49	the	the	DET
admet-704	3	50	protocol	protocol	NOUN
admet-704	3	51	of	of	ADP
admet-704	3	52	equilibrium	equilibrium	NOUN
admet-704	3	53	solubility	solubility	NOUN
admet-704	3	54	measurements	measurement	NOUN
admet-704	3	55	for	for	ADP
admet-704	3	56	poorly	poorly	ADV
admet-704	3	57	water	water	NOUN
admet-704	3	58	-	-	PUNCT
admet-704	3	59	soluble	soluble	ADJ
admet-704	3	60	drugs	drug	NOUN
admet-704	3	61	to	to	PART
admet-704	3	62	lower	lower	VERB
admet-704	3	63	inter	inter	ADJ
admet-704	3	64	-	-	ADJ
admet-704	3	65	laboratory	laboratory	ADJ
admet-704	3	66	variance	variance	NOUN
admet-704	3	67	.	.	PUNCT
admet-704	4	1	the	the	DET
admet-704	4	2	“	"	PUNCT
admet-704	4	3	mandatory	mandatory	ADJ
admet-704	4	4	”	"	PUNCT
admet-704	4	5	and	and	CCONJ
admet-704	4	6	“	"	PUNCT
admet-704	4	7	recommended	recommend	VERB
admet-704	4	8	”	"	PUNCT
admet-704	4	9	procedures	procedure	NOUN
admet-704	4	10	for	for	ADP
admet-704	4	11	the	the	DET
admet-704	4	12	shake	shake	NOUN
admet-704	4	13	-	-	PUNCT
admet-704	4	14	flask	flask	NOUN
admet-704	4	15	method	method	NOUN
admet-704	4	16	were	be	AUX
admet-704	4	17	harmonized	harmonize	VERB
admet-704	4	18	based	base	VERB
admet-704	4	19	on	on	ADP
admet-704	4	20	the	the	DET
admet-704	4	21	knowledge	knowledge	NOUN
admet-704	4	22	and	and	CCONJ
admet-704	4	23	experiences	experience	NOUN
admet-704	4	24	of	of	ADP
admet-704	4	25	each	each	DET
admet-704	4	26	company	company	NOUN
admet-704	4	27	and	and	CCONJ
admet-704	4	28	information	information	NOUN
admet-704	4	29	from	from	ADP
admet-704	4	30	the	the	DET
admet-704	4	31	literature	literature	NOUN
admet-704	4	32	.	.	PUNCT
admet-704	5	1	the	the	DET
admet-704	5	2	solubility	solubility	NOUN
admet-704	5	3	of	of	ADP
admet-704	5	4	model	model	NOUN
admet-704	5	5	drugs	drug	NOUN
admet-704	5	6	was	be	AUX
admet-704	5	7	measured	measure	VERB
admet-704	5	8	by	by	ADP
admet-704	5	9	the	the	DET
admet-704	5	10	harmonized	harmonized	ADJ
admet-704	5	11	protocol	protocol	NOUN
admet-704	5	12	(	(	PUNCT
admet-704	5	13	hp	hp	NOUN
admet-704	5	14	)	)	PUNCT
admet-704	5	15	and	and	CCONJ
admet-704	5	16	the	the	DET
admet-704	5	17	non	non	ADJ
admet-704	5	18	-	-	ADJ
admet-704	5	19	harmonized	harmonized	ADJ
admet-704	5	20	proprietary	proprietary	ADJ
admet-704	5	21	protocol	protocol	NOUN
admet-704	5	22	of	of	ADP
admet-704	5	23	each	each	DET
admet-704	5	24	company	company	NOUN
admet-704	5	25	(	(	PUNCT
admet-704	5	26	nonhp	nonhp	PROPN
admet-704	5	27	)	)	PUNCT
admet-704	5	28	.	.	PUNCT
admet-704	6	1	albendazole	albendazole	ADJ
admet-704	6	2	,	,	PUNCT
admet-704	6	3	griseofulvin	griseofulvin	NOUN
admet-704	6	4	,	,	PUNCT
admet-704	6	5	dipyridamole	dipyridamole	NOUN
admet-704	6	6	,	,	PUNCT
admet-704	6	7	and	and	CCONJ
admet-704	6	8	glibenclamide	glibenclamide	NOUN
admet-704	6	9	were	be	AUX
admet-704	6	10	used	use	VERB
admet-704	6	11	as	as	ADP
admet-704	6	12	model	model	NOUN
admet-704	6	13	drugs	drug	NOUN
admet-704	6	14	.	.	PUNCT
admet-704	7	1	when	when	SCONJ
admet-704	7	2	using	use	VERB
admet-704	7	3	the	the	DET
admet-704	7	4	nonhp	nonhp	NOUN
admet-704	7	5	,	,	PUNCT
admet-704	7	6	the	the	DET
admet-704	7	7	solubility	solubility	NOUN
admet-704	7	8	values	value	NOUN
admet-704	7	9	showed	show	VERB
admet-704	7	10	large	large	ADJ
admet-704	7	11	inter	inter	ADJ
admet-704	7	12	-	-	ADJ
admet-704	7	13	laboratory	laboratory	ADJ
admet-704	7	14	variance	variance	NOUN
admet-704	7	15	.	.	PUNCT
admet-704	8	1	in	in	ADP
admet-704	8	2	contrast	contrast	NOUN
admet-704	8	3	,	,	PUNCT
admet-704	8	4	inter	inter	ADJ
admet-704	8	5	-	-	ADJ
admet-704	8	6	laboratory	laboratory	ADJ
admet-704	8	7	variance	variance	NOUN
admet-704	8	8	was	be	AUX
admet-704	8	9	markedly	markedly	ADV
admet-704	8	10	reduced	reduce	VERB
admet-704	8	11	when	when	SCONJ
admet-704	8	12	using	use	VERB
admet-704	8	13	the	the	DET
admet-704	8	14	hp	hp	PROPN
admet-704	8	15	.	.	PUNCT
admet-704	9	1	keywords	keyword	VERB
admet-704	9	2	shake	shake	VERB
admet-704	9	3	-	-	PUNCT
admet-704	9	4	flask	flask	NOUN
admet-704	9	5	solubility	solubility	NOUN
admet-704	9	6	;	;	PUNCT
admet-704	9	7	equilibrium	equilibrium	NOUN
admet-704	9	8	solubility	solubility	NOUN
admet-704	9	9	;	;	PUNCT
admet-704	9	10	poorly	poorly	ADV
admet-704	9	11	water	water	NOUN
admet-704	9	12	-	-	PUNCT
admet-704	9	13	soluble	soluble	ADJ
admet-704	9	14	drugs	drug	NOUN
admet-704	9	15	.	.	PUNCT
admet-704	10	1	introduction	introduction	NOUN
admet-704	10	2	in	in	ADP
admet-704	10	3	recent	recent	ADJ
admet-704	10	4	years	year	NOUN
admet-704	10	5	,	,	PUNCT
admet-704	10	6	drug	drug	NOUN
admet-704	10	7	candidates	candidate	NOUN
admet-704	10	8	have	have	AUX
admet-704	10	9	tended	tend	VERB
admet-704	10	10	to	to	PART
admet-704	10	11	be	be	AUX
admet-704	10	12	poorly	poorly	ADV
admet-704	10	13	water	water	NOUN
admet-704	10	14	-	-	PUNCT
admet-704	10	15	soluble	soluble	ADJ
admet-704	10	16	[	[	X
admet-704	10	17	1	1	NUM
admet-704	10	18	-	-	SYM
admet-704	10	19	3	3	NUM
admet-704	10	20	]	]	PUNCT
admet-704	10	21	.	.	PUNCT
admet-704	11	1	the	the	DET
admet-704	11	2	oral	oral	ADJ
admet-704	11	3	absorption	absorption	NOUN
admet-704	11	4	of	of	ADP
admet-704	11	5	a	a	DET
admet-704	11	6	drug	drug	NOUN
admet-704	11	7	is	be	AUX
admet-704	11	8	determined	determine	VERB
admet-704	11	9	by	by	ADP
admet-704	11	10	the	the	DET
admet-704	11	11	solubility	solubility	NOUN
admet-704	11	12	,	,	PUNCT
admet-704	11	13	dissolution	dissolution	NOUN
admet-704	11	14	rate	rate	NOUN
admet-704	11	15	,	,	PUNCT
admet-704	11	16	and	and	CCONJ
admet-704	11	17	membrane	membrane	NOUN
admet-704	11	18	permeability	permeability	NOUN
admet-704	11	19	of	of	ADP
admet-704	11	20	the	the	DET
admet-704	11	21	drug	drug	NOUN
admet-704	11	22	in	in	ADP
admet-704	11	23	the	the	DET
admet-704	11	24	gastrointestinal	gastrointestinal	ADJ
admet-704	11	25	tract	tract	NOUN
admet-704	12	1	[	[	X
admet-704	12	2	4	4	NUM
admet-704	12	3	-	-	SYM
admet-704	12	4	7	7	NUM
admet-704	12	5	]	]	PUNCT
admet-704	12	6	.	.	PUNCT
admet-704	13	1	poor	poor	ADJ
admet-704	13	2	water	water	NOUN
admet-704	13	3	-	-	PUNCT
admet-704	13	4	solubility	solubility	NOUN
admet-704	13	5	often	often	ADV
admet-704	13	6	causes	cause	VERB
admet-704	13	7	poor	poor	ADJ
admet-704	13	8	and	and	CCONJ
admet-704	13	9	variable	variable	ADJ
admet-704	13	10	oral	oral	ADJ
admet-704	13	11	absorption	absorption	NOUN
admet-704	14	1	[	[	X
admet-704	14	2	8	8	NUM
admet-704	14	3	-	-	SYM
admet-704	14	4	11	11	NUM
admet-704	14	5	]	]	PUNCT
admet-704	14	6	.	.	PUNCT
admet-704	15	1	therefore	therefore	ADV
admet-704	15	2	,	,	PUNCT
admet-704	15	3	solubility	solubility	NOUN
admet-704	15	4	measurements	measurement	NOUN
admet-704	15	5	are	be	AUX
admet-704	15	6	routinely	routinely	ADV
admet-704	15	7	performed	perform	VERB
admet-704	15	8	in	in	ADP
admet-704	15	9	drug	drug	NOUN
admet-704	15	10	discovery	discovery	NOUN
admet-704	15	11	and	and	CCONJ
admet-704	15	12	development	development	NOUN
admet-704	16	1	[	[	X
admet-704	16	2	12	12	NUM
admet-704	16	3	-	-	SYM
admet-704	16	4	15	15	NUM
admet-704	16	5	]	]	PUNCT
admet-704	16	6	.	.	PUNCT
admet-704	17	1	the	the	DET
admet-704	17	2	quality	quality	NOUN
admet-704	17	3	of	of	ADP
admet-704	17	4	solubility	solubility	NOUN
admet-704	17	5	data	datum	NOUN
admet-704	17	6	is	be	AUX
admet-704	17	7	critically	critically	ADV
admet-704	17	8	important	important	ADJ
admet-704	17	9	for	for	ADP
admet-704	17	10	drug	drug	NOUN
admet-704	17	11	design	design	NOUN
admet-704	17	12	[	[	X
admet-704	17	13	16	16	NUM
admet-704	17	14	-	-	SYM
admet-704	17	15	19	19	NUM
admet-704	17	16	]	]	PUNCT
admet-704	17	17	,	,	PUNCT
admet-704	17	18	oral	oral	ADJ
admet-704	17	19	absorption	absorption	NOUN
admet-704	17	20	prediction	prediction	NOUN
admet-704	18	1	[	[	X
admet-704	18	2	20mailto:ono.ar@om.asahi-kasei.co.jp	20mailto:ono.ar@om.asahi-kasei.co.jp	NOUN
admet-704	18	3	asami	asami	PROPN
admet-704	18	4	ono	ono	PROPN
admet-704	18	5	et	et	PROPN
admet-704	18	6	.	.	PUNCT
admet-704	19	1	al	al	PROPN
admet-704	19	2	admet	admet	PROPN
admet-704	19	3	&	&	CCONJ
admet-704	19	4	dmpk	dmpk	PROPN
admet-704	19	5	7(3	7(3	NUM
admet-704	19	6	)	)	PUNCT
admet-704	19	7	(	(	PUNCT
admet-704	19	8	2019	2019	NUM
admet-704	19	9	)	)	PUNCT
admet-704	19	10	183	183	NUM
admet-704	19	11	-	-	SYM
admet-704	19	12	195	195	NUM
admet-704	19	13	184	184	NUM
admet-704	19	14	23	23	NUM
admet-704	19	15	]	]	PUNCT
admet-704	19	16	,	,	PUNCT
admet-704	19	17	and	and	CCONJ
admet-704	19	18	formulation	formulation	NOUN
admet-704	19	19	development	development	NOUN
admet-704	19	20	[	[	X
admet-704	19	21	24	24	NUM
admet-704	19	22	-	-	SYM
admet-704	19	23	26	26	NUM
admet-704	19	24	]	]	PUNCT
admet-704	19	25	.	.	PUNCT
admet-704	20	1	however	however	ADV
admet-704	20	2	,	,	PUNCT
admet-704	20	3	the	the	DET
admet-704	20	4	solubility	solubility	NOUN
admet-704	20	5	values	value	NOUN
admet-704	20	6	of	of	ADP
admet-704	20	7	poorly	poorly	ADV
admet-704	20	8	water	water	NOUN
admet-704	20	9	-	-	PUNCT
admet-704	20	10	soluble	soluble	ADJ
admet-704	20	11	drugs	drug	NOUN
admet-704	20	12	vary	vary	VERB
admet-704	20	13	depending	depend	VERB
admet-704	20	14	on	on	ADP
admet-704	20	15	the	the	DET
admet-704	20	16	experimental	experimental	ADJ
admet-704	20	17	procedures	procedure	NOUN
admet-704	20	18	[	[	X
admet-704	20	19	27	27	NUM
admet-704	20	20	]	]	PUNCT
admet-704	20	21	.	.	PUNCT
admet-704	21	1	recently	recently	ADV
admet-704	21	2	,	,	PUNCT
admet-704	21	3	avdeef	avdeef	PROPN
admet-704	21	4	et	et	PROPN
admet-704	21	5	al	al	PROPN
admet-704	21	6	.	.	PROPN
admet-704	21	7	reported	report	VERB
admet-704	21	8	consensus	consensus	NOUN
admet-704	21	9	recommendations	recommendation	NOUN
admet-704	21	10	on	on	ADP
admet-704	21	11	the	the	DET
admet-704	21	12	experimental	experimental	ADJ
admet-704	21	13	procedures	procedure	NOUN
admet-704	21	14	of	of	ADP
admet-704	21	15	equilibrium	equilibrium	NOUN
admet-704	21	16	solubility	solubility	NOUN
admet-704	21	17	measurements	measurement	NOUN
admet-704	21	18	by	by	ADP
admet-704	21	19	the	the	DET
admet-704	21	20	shake	shake	NOUN
admet-704	21	21	-	-	PUNCT
admet-704	21	22	flask	flask	NOUN
admet-704	21	23	method	method	NOUN
admet-704	21	24	[	[	X
admet-704	21	25	28	28	NUM
admet-704	21	26	]	]	PUNCT
admet-704	21	27	.	.	PUNCT
admet-704	22	1	they	they	PRON
admet-704	22	2	discussed	discuss	VERB
admet-704	22	3	various	various	ADJ
admet-704	22	4	aspects	aspect	NOUN
admet-704	22	5	of	of	ADP
admet-704	22	6	equilibrium	equilibrium	NOUN
admet-704	22	7	solubility	solubility	NOUN
admet-704	22	8	measurements	measurement	NOUN
admet-704	22	9	,	,	PUNCT
admet-704	22	10	such	such	ADJ
admet-704	22	11	as	as	ADP
admet-704	22	12	incubation	incubation	NOUN
admet-704	22	13	temperature	temperature	NOUN
admet-704	22	14	,	,	PUNCT
admet-704	22	15	incubation	incubation	NOUN
admet-704	22	16	time	time	NOUN
admet-704	22	17	,	,	PUNCT
admet-704	22	18	the	the	DET
admet-704	22	19	separation	separation	NOUN
admet-704	22	20	method	method	NOUN
admet-704	22	21	of	of	ADP
admet-704	22	22	solids	solid	NOUN
admet-704	22	23	from	from	ADP
admet-704	22	24	solution	solution	NOUN
admet-704	22	25	,	,	PUNCT
admet-704	22	26	and	and	CCONJ
admet-704	22	27	ph	ph	ADJ
admet-704	22	28	measurements	measurement	NOUN
admet-704	22	29	.	.	PUNCT
admet-704	23	1	as	as	ADP
admet-704	23	2	a	a	DET
admet-704	23	3	part	part	NOUN
admet-704	23	4	of	of	ADP
admet-704	23	5	the	the	DET
admet-704	23	6	consortium	consortium	NOUN
admet-704	23	7	of	of	ADP
admet-704	23	8	biopharmaceutical	biopharmaceutical	ADJ
admet-704	23	9	tools	tool	NOUN
admet-704	23	10	(	(	PUNCT
admet-704	23	11	cobito	cobito	ADJ
admet-704	23	12	)	)	PUNCT
admet-704	23	13	project	project	NOUN
admet-704	23	14	,	,	PUNCT
admet-704	23	15	we	we	PRON
admet-704	23	16	conducted	conduct	VERB
admet-704	23	17	a	a	DET
admet-704	23	18	questionnaire	questionnaire	NOUN
admet-704	23	19	concerning	concern	VERB
admet-704	23	20	the	the	DET
admet-704	23	21	solubility	solubility	NOUN
admet-704	23	22	measurements	measurement	NOUN
admet-704	23	23	of	of	ADP
admet-704	23	24	each	each	DET
admet-704	23	25	company	company	NOUN
admet-704	23	26	.	.	PUNCT
admet-704	24	1	it	it	PRON
admet-704	24	2	was	be	AUX
admet-704	24	3	revealed	reveal	VERB
admet-704	24	4	that	that	SCONJ
admet-704	24	5	each	each	DET
admet-704	24	6	company	company	NOUN
admet-704	24	7	employs	employ	VERB
admet-704	24	8	different	different	ADJ
admet-704	24	9	experimental	experimental	ADJ
admet-704	24	10	procedures	procedure	NOUN
admet-704	24	11	(	(	PUNCT
admet-704	24	12	table	table	NOUN
admet-704	24	13	1	1	NUM
admet-704	24	14	)	)	PUNCT
admet-704	24	15	,	,	PUNCT
admet-704	24	16	suggesting	suggest	VERB
admet-704	24	17	that	that	SCONJ
admet-704	24	18	there	there	PRON
admet-704	24	19	would	would	AUX
admet-704	24	20	be	be	AUX
admet-704	24	21	large	large	ADJ
admet-704	24	22	inter	inter	ADJ
admet-704	24	23	-	-	ADJ
admet-704	24	24	laboratory	laboratory	ADJ
admet-704	24	25	variance	variance	NOUN
admet-704	24	26	in	in	ADP
admet-704	24	27	solubility	solubility	NOUN
admet-704	24	28	data	datum	NOUN
admet-704	24	29	.	.	PUNCT
admet-704	25	1	table	table	NOUN
admet-704	25	2	1	1	NUM
admet-704	25	3	.	.	PUNCT
admet-704	26	1	summary	summary	NOUN
admet-704	26	2	of	of	ADP
admet-704	26	3	solubility	solubility	NOUN
admet-704	26	4	measurement	measurement	NOUN
admet-704	26	5	protocols	protocol	NOUN
admet-704	26	6	of	of	ADP
admet-704	26	7	each	each	DET
admet-704	26	8	company	company	NOUN
admet-704	26	9	before	before	ADP
admet-704	26	10	harmonization	harmonization	NOUN
admet-704	26	11	.	.	PUNCT
admet-704	27	1	company	company	NOUN
admet-704	27	2	a	a	DET
admet-704	27	3	b	b	NOUN
admet-704	27	4	c	c	NOUN
admet-704	27	5	d	d	X
admet-704	27	6	e	e	X
admet-704	27	7	f	f	PROPN
admet-704	27	8	h	h	PROPN
admet-704	27	9	vigorous	vigorous	ADJ
admet-704	27	10	agitation	agitation	NOUN
admet-704	28	1	yes	yes	INTJ
admet-704	28	2	yes	yes	INTJ
admet-704	29	1	no	no	INTJ
admet-704	30	1	yes	yes	INTJ
admet-704	31	1	yes	yes	INTJ
admet-704	32	1	yes	yes	INTJ
admet-704	32	2	no	no	DET
admet-704	32	3	temperature	temperature	NOUN
admet-704	32	4	control	control	NOUN
admet-704	33	1	yes	yes	INTJ
admet-704	33	2	(	(	PUNCT
admet-704	33	3	25	25	NUM
admet-704	33	4	°	°	NOUN
admet-704	33	5	c	c	NOUN
admet-704	33	6	)	)	PUNCT
admet-704	33	7	yes	yes	INTJ
admet-704	33	8	(	(	PUNCT
admet-704	33	9	37	37	NUM
admet-704	33	10	°	°	NOUN
admet-704	33	11	c	c	NOUN
admet-704	33	12	)	)	PUNCT
admet-704	33	13	yes	yes	INTJ
admet-704	33	14	(	(	PUNCT
admet-704	33	15	37	37	NUM
admet-704	33	16	°	°	NOUN
admet-704	33	17	c	c	NOUN
admet-704	33	18	)	)	PUNCT
admet-704	33	19	yes	yes	INTJ
admet-704	33	20	(	(	PUNCT
admet-704	33	21	37	37	NUM
admet-704	33	22	°	°	NOUN
admet-704	33	23	c	c	NOUN
admet-704	33	24	)	)	PUNCT
admet-704	33	25	yes	yes	INTJ
admet-704	33	26	(	(	PUNCT
admet-704	33	27	37	37	NUM
admet-704	33	28	°	°	NOUN
admet-704	33	29	c	c	NOUN
admet-704	33	30	)	)	PUNCT
admet-704	33	31	yes	yes	INTJ
admet-704	33	32	(	(	PUNCT
admet-704	33	33	37	37	NUM
admet-704	33	34	°	°	NOUN
admet-704	33	35	c	c	NOUN
admet-704	33	36	)	)	PUNCT
admet-704	33	37	yes	yes	INTJ
admet-704	33	38	(	(	PUNCT
admet-704	33	39	37	37	NUM
admet-704	33	40	°	°	NUM
admet-704	33	41	c	c	NOUN
admet-704	33	42	)	)	PUNCT
admet-704	33	43	equilibration	equilibration	NOUN
admet-704	33	44	for	for	ADP
admet-704	33	45	>	>	X
admet-704	33	46	24	24	NUM
admet-704	33	47	h	h	NOUN
admet-704	33	48	no	no	INTJ
admet-704	33	49	(	(	PUNCT
admet-704	33	50	18	18	NUM
admet-704	33	51	h	h	NOUN
admet-704	33	52	)	)	PUNCT
admet-704	33	53	no	no	INTJ
admet-704	33	54	(	(	PUNCT
admet-704	33	55	1	1	NUM
admet-704	33	56	h	h	NOUN
admet-704	33	57	)	)	PUNCT
admet-704	33	58	yes	yes	INTJ
admet-704	33	59	(	(	PUNCT
admet-704	33	60	24	24	NUM
admet-704	33	61	h	h	NOUN
admet-704	33	62	)	)	PUNCT
admet-704	33	63	yes	yes	INTJ
admet-704	33	64	(	(	PUNCT
admet-704	33	65	24	24	NUM
admet-704	33	66	h	h	NOUN
admet-704	33	67	)	)	PUNCT
admet-704	33	68	yes	yes	INTJ
admet-704	33	69	(	(	PUNCT
admet-704	33	70	24	24	NUM
admet-704	33	71	h	h	NOUN
admet-704	33	72	)	)	PUNCT
admet-704	33	73	yes	yes	INTJ
admet-704	33	74	(	(	PUNCT
admet-704	33	75	24	24	NUM
admet-704	33	76	h	h	NOUN
admet-704	33	77	)	)	PUNCT
admet-704	33	78	yes	yes	INTJ
admet-704	33	79	(	(	PUNCT
admet-704	33	80	24	24	NUM
admet-704	33	81	h	h	NOUN
admet-704	33	82	)	)	PUNCT
admet-704	33	83	pre	pre	NOUN
admet-704	33	84	-	-	NOUN
admet-704	33	85	saturation	saturation	NOUN
admet-704	33	86	of	of	ADP
admet-704	33	87	filter	filter	NOUN
admet-704	34	1	no	no	INTJ
admet-704	34	2	yes	yes	INTJ
admet-704	35	1	no	no	INTJ
admet-704	36	1	yes	yes	INTJ
admet-704	36	2	no	no	INTJ
admet-704	37	1	a	a	INTJ
admet-704	37	2	yes	yes	INTJ
admet-704	37	3	no	no	DET
admet-704	37	4	preventing	prevent	VERB
admet-704	37	5	adsorption	adsorption	NOUN
admet-704	38	1	no	no	INTJ
admet-704	38	2	yes	yes	INTJ
admet-704	39	1	no	no	INTJ
admet-704	40	1	yes	yes	INTJ
admet-704	41	1	no	no	INTJ
admet-704	42	1	yes	yes	INTJ
admet-704	42	2	no	no	DET
admet-704	42	3	solid	solid	ADJ
admet-704	42	4	state	state	NOUN
admet-704	42	5	characterization	characterization	NOUN
admet-704	43	1	no	no	INTJ
admet-704	43	2	no	no	INTJ
admet-704	44	1	no	no	INTJ
admet-704	45	1	yes	yes	INTJ
admet-704	46	1	no	no	INTJ
admet-704	47	1	yes	yes	INTJ
admet-704	47	2	no	no	INTJ
admet-704	47	3	a	a	DET
admet-704	47	4	separated	separate	VERB
admet-704	47	5	by	by	ADP
admet-704	47	6	centrifugation	centrifugation	NOUN
admet-704	47	7	.	.	PUNCT
admet-704	48	1	the	the	DET
admet-704	48	2	purpose	purpose	NOUN
admet-704	48	3	of	of	ADP
admet-704	48	4	the	the	DET
admet-704	48	5	present	present	ADJ
admet-704	48	6	study	study	NOUN
admet-704	48	7	was	be	AUX
admet-704	48	8	to	to	PART
admet-704	48	9	harmonize	harmonize	VERB
admet-704	48	10	the	the	DET
admet-704	48	11	experimental	experimental	ADJ
admet-704	48	12	procedures	procedure	NOUN
admet-704	48	13	of	of	ADP
admet-704	48	14	solubility	solubility	NOUN
admet-704	48	15	measurements	measurement	NOUN
admet-704	48	16	by	by	ADP
admet-704	48	17	the	the	DET
admet-704	48	18	shake	shake	NOUN
admet-704	48	19	-	-	PUNCT
admet-704	48	20	flask	flask	NOUN
admet-704	48	21	method	method	NOUN
admet-704	48	22	for	for	ADP
admet-704	48	23	low	low	ADJ
admet-704	48	24	solubility	solubility	NOUN
admet-704	48	25	drugs	drug	NOUN
admet-704	48	26	to	to	PART
admet-704	48	27	lower	lower	VERB
admet-704	48	28	inter	inter	ADJ
admet-704	48	29	-	-	ADJ
admet-704	48	30	laboratory	laboratory	ADJ
admet-704	48	31	variance	variance	NOUN
admet-704	48	32	.	.	PUNCT
admet-704	49	1	albendazole	albendazole	ADJ
admet-704	49	2	,	,	PUNCT
admet-704	49	3	griseofulvin	griseofulvin	NOUN
admet-704	49	4	,	,	PUNCT
admet-704	49	5	dipyridamole	dipyridamole	NOUN
admet-704	49	6	,	,	PUNCT
admet-704	49	7	and	and	CCONJ
admet-704	49	8	glibenclamide	glibenclamide	NOUN
admet-704	49	9	were	be	AUX
admet-704	49	10	used	use	VERB
admet-704	49	11	as	as	ADP
admet-704	49	12	model	model	NOUN
admet-704	49	13	drugs	drug	NOUN
admet-704	49	14	(	(	PUNCT
admet-704	49	15	table	table	NOUN
admet-704	49	16	2	2	NUM
admet-704	49	17	,	,	PUNCT
admet-704	49	18	figures	figure	NOUN
admet-704	49	19	1	1	NUM
admet-704	49	20	and	and	CCONJ
admet-704	49	21	2	2	NUM
admet-704	49	22	)	)	PUNCT
admet-704	49	23	.	.	PUNCT
admet-704	50	1	figure	figure	NOUN
admet-704	50	2	1	1	NUM
admet-704	50	3	.	.	PUNCT
admet-704	51	1	chemical	chemical	NOUN
admet-704	51	2	structures	structure	NOUN
admet-704	51	3	of	of	ADP
admet-704	51	4	model	model	NOUN
admet-704	51	5	drugs	drug	NOUN
admet-704	51	6	.	.	PUNCT
admet-704	52	1	admet	admet	PROPN
admet-704	52	2	&	&	CCONJ
admet-704	52	3	dmpk	dmpk	PROPN
admet-704	52	4	7(3	7(3	NUM
admet-704	52	5	)	)	PUNCT
admet-704	52	6	(	(	PUNCT
admet-704	52	7	2019	2019	NUM
admet-704	52	8	)	)	PUNCT
admet-704	52	9	183	183	NUM
admet-704	52	10	-	-	SYM
admet-704	52	11	195	195	NUM
admet-704	52	12	harmonizing	harmonize	VERB
admet-704	52	13	solubility	solubility	NOUN
admet-704	52	14	measurement	measurement	NOUN
admet-704	52	15	to	to	PART
admet-704	52	16	lower	lower	VERB
admet-704	52	17	inter	inter	ADJ
admet-704	52	18	-	-	ADJ
admet-704	52	19	laboratory	laboratory	ADJ
admet-704	52	20	variance	variance	NOUN
admet-704	52	21	doi	doi	NOUN
admet-704	52	22	:	:	PUNCT
admet-704	52	23	10.5599	10.5599	NUM
admet-704	52	24	/	/	SYM
admet-704	52	25	admet.704	admet.704	ADJ
admet-704	52	26	185	185	NUM
admet-704	52	27	table	table	NOUN
admet-704	52	28	2	2	NUM
admet-704	52	29	.	.	NOUN
admet-704	52	30	physicochemical	physicochemical	ADJ
admet-704	52	31	properties	property	NOUN
admet-704	52	32	of	of	ADP
admet-704	52	33	model	model	NOUN
admet-704	52	34	drugs	drug	NOUN
admet-704	52	35	.	.	PUNCT
admet-704	53	1	compound	compound	NOUN
admet-704	53	2	mw	mw	X
admet-704	54	1	pka	pka	PROPN
admet-704	54	2	a	a	DET
admet-704	54	3	log	log	NOUN
admet-704	54	4	poct	poct	PROPN
admet-704	54	5	b	b	X
admet-704	54	6	lit	lit	NOUN
admet-704	54	7	.	.	PUNCT
admet-704	55	1	solubility	solubility	NOUN
admet-704	55	2	calculated	calculate	VERB
admet-704	55	3	solubility	solubility	NOUN
admet-704	55	4	at	at	ADP
admet-704	55	5	ph6.8	ph6.8	X
admet-704	55	6	c	c	NOUN
admet-704	55	7	,	,	PUNCT
admet-704	55	8	μg	μg	PROPN
admet-704	55	9	/	/	SYM
admet-704	55	10	ml	ml	NOUN
admet-704	55	11	ref	ref	NOUN
admet-704	55	12	.	.	PUNCT
admet-704	56	1	solubility	solubility	NOUN
admet-704	56	2	(	(	PUNCT
admet-704	56	3	37	37	NUM
admet-704	56	4	°	°	NOUN
admet-704	56	5	c	c	NOUN
admet-704	56	6	)	)	PUNCT
admet-704	56	7	,	,	PUNCT
admet-704	56	8	μg	μg	PROPN
admet-704	56	9	/	/	SYM
admet-704	56	10	ml	ml	X
admet-704	56	11	ph	ph	ADJ
admet-704	56	12	albendazole	albendazole	NOUN
admet-704	56	13	265	265	NUM
admet-704	56	14	4.2	4.2	NUM
admet-704	56	15	(	(	PUNCT
admet-704	56	16	base	base	NOUN
admet-704	56	17	)	)	PUNCT
admet-704	56	18	3.1	3.1	NUM
admet-704	56	19	0.20	0.20	NUM
admet-704	56	20	(	(	PUNCT
admet-704	56	21	25	25	NUM
admet-704	56	22	°	°	NOUN
admet-704	56	23	c	c	NOUN
admet-704	56	24	)	)	PUNCT
admet-704	56	25	7.4	7.4	NUM
admet-704	56	26	0.20	0.20	NUM
admet-704	56	27	31	31	NUM
admet-704	56	28	(	(	PUNCT
admet-704	56	29	25	25	NUM
admet-704	56	30	°	°	NOUN
admet-704	56	31	c	c	NOUN
admet-704	56	32	)	)	PUNCT
admet-704	56	33	0.95	0.95	NUM
admet-704	56	34	7	7	NUM
admet-704	56	35	0.95	0.95	NUM
admet-704	56	36	32	32	NUM
admet-704	56	37	0.74	0.74	NUM
admet-704	56	38	(	(	PUNCT
admet-704	56	39	intrinsic	intrinsic	ADJ
admet-704	56	40	solubility	solubility	NOUN
admet-704	56	41	)	)	PUNCT
admet-704	56	42	0.74	0.74	NUM
admet-704	56	43	33	33	NUM
admet-704	56	44	0.85	0.85	NUM
admet-704	56	45	d	d	NOUN
admet-704	56	46	6.5	6.5	NUM
admet-704	56	47	0.85	0.85	NUM
admet-704	56	48	34	34	NUM
admet-704	56	49	1.1	1.1	NUM
admet-704	56	50	d	d	SYM
admet-704	56	51	5	5	NUM
admet-704	56	52	0.95	0.95	NUM
admet-704	56	53	34	34	NUM
admet-704	56	54	0.80	0.80	NUM
admet-704	56	55	d	d	NOUN
admet-704	56	56	6.5	6.5	NUM
admet-704	56	57	0.79	0.79	NUM
admet-704	56	58	35	35	NUM
admet-704	56	59	griseofulvin	griseofulvin	NOUN
admet-704	56	60	353	353	NUM
admet-704	56	61	n	n	NOUN
admet-704	56	62	/	/	SYM
admet-704	56	63	a	a	DET
admet-704	56	64	e	e	NOUN
admet-704	56	65	2.5	2.5	NUM
admet-704	56	66	5.3	5.3	NUM
admet-704	56	67	(	(	PUNCT
admet-704	56	68	25	25	NUM
admet-704	56	69	°	°	NOUN
admet-704	56	70	c	c	NOUN
admet-704	56	71	)	)	PUNCT
admet-704	56	72	7.4	7.4	NUM
admet-704	56	73	n	n	NOUN
admet-704	56	74	/	/	SYM
admet-704	56	75	a	a	DET
admet-704	56	76	31	31	NUM
admet-704	56	77	15	15	NUM
admet-704	56	78	d	d	SYM
admet-704	56	79	6.5	6.5	NUM
admet-704	56	80	n	n	NOUN
admet-704	56	81	/	/	SYM
admet-704	56	82	a	a	DET
admet-704	56	83	35	35	NUM
admet-704	56	84	15	15	NUM
admet-704	56	85	6.5	6.5	NUM
admet-704	56	86	n	n	CCONJ
admet-704	56	87	/	/	SYM
admet-704	56	88	a	a	DET
admet-704	56	89	36	36	NUM
admet-704	56	90	16	16	NUM
admet-704	56	91	6.5	6.5	NUM
admet-704	56	92	n	n	CCONJ
admet-704	56	93	/	/	SYM
admet-704	56	94	a	a	DET
admet-704	56	95	37	37	NUM
admet-704	56	96	dipyridamole	dipyridamole	NOUN
admet-704	56	97	505	505	NUM
admet-704	56	98	4.9	4.9	NUM
admet-704	56	99	(	(	PUNCT
admet-704	56	100	base	base	NOUN
admet-704	56	101	)	)	PUNCT
admet-704	56	102	3.9	3.9	NUM
admet-704	56	103	4.9	4.9	NUM
admet-704	56	104	7	7	NUM
admet-704	56	105	4.9	4.9	NUM
admet-704	56	106	32	32	NUM
admet-704	56	107	(	(	PUNCT
admet-704	56	108	37	37	NUM
admet-704	56	109	°	°	NOUN
admet-704	56	110	c	c	NOUN
admet-704	56	111	)	)	PUNCT
admet-704	56	112	6.6	6.6	NUM
admet-704	56	113	d	d	NOUN
admet-704	56	114	6.5	6.5	NUM
admet-704	56	115	6.5	6.5	NUM
admet-704	56	116	35	35	NUM
admet-704	56	117	5.4	5.4	NUM
admet-704	56	118	6.5	6.5	NUM
admet-704	56	119	5.3	5.3	NUM
admet-704	56	120	36	36	NUM
admet-704	56	121	6	6	NUM
admet-704	56	122	6.5	6.5	NUM
admet-704	56	123	5.9	5.9	NUM
admet-704	56	124	37	37	NUM
admet-704	56	125	glibenclamide	glibenclamide	ADP
admet-704	56	126	494	494	NUM
admet-704	56	127	5.2	5.2	NUM
admet-704	56	128	(	(	PUNCT
admet-704	56	129	acid	acid	NOUN
admet-704	56	130	)	)	PUNCT
admet-704	56	131	3.1	3.1	NUM
admet-704	56	132	4.4	4.4	NUM
admet-704	56	133	(	(	PUNCT
admet-704	56	134	25	25	NUM
admet-704	56	135	°	°	NOUN
admet-704	56	136	c	c	NOUN
admet-704	56	137	)	)	PUNCT
admet-704	56	138	7.4	7.4	NUM
admet-704	56	139	1.1	1.1	NUM
admet-704	56	140	31	31	NUM
admet-704	56	141	(	(	PUNCT
admet-704	56	142	37	37	NUM
admet-704	56	143	°	°	NOUN
admet-704	56	144	c	c	NOUN
admet-704	56	145	)	)	PUNCT
admet-704	56	146	5.6	5.6	NUM
admet-704	56	147	7	7	NUM
admet-704	56	148	3.6	3.6	NUM
admet-704	56	149	32	32	NUM
admet-704	56	150	4.5	4.5	NUM
admet-704	56	151	d	d	SYM
admet-704	56	152	6.5	6.5	NUM
admet-704	56	153	8.8	8.8	NUM
admet-704	56	154	34	34	NUM
admet-704	56	155	0.3	0.3	NUM
admet-704	56	156	d	d	SYM
admet-704	56	157	5	5	NUM
admet-704	56	158	7.5	7.5	NUM
admet-704	56	159	34	34	NUM
admet-704	56	160	4.4	4.4	NUM
admet-704	56	161	d	d	SYM
admet-704	56	162	6.5	6.5	NUM
admet-704	56	163	8.7	8.7	NUM
admet-704	56	164	35	35	NUM
admet-704	56	165	3.0	3.0	NUM
admet-704	56	166	6.5	6.5	NUM
admet-704	56	167	5.8	5.8	NUM
admet-704	56	168	38	38	NUM
admet-704	56	169	0.30	0.30	NUM
admet-704	56	170	5	5	NUM
admet-704	56	171	7.5	7.5	NUM
admet-704	56	172	38	38	NUM
admet-704	56	173	a	a	DET
admet-704	56	174	reference	reference	NOUN
admet-704	56	175	[	[	X
admet-704	56	176	29	29	NUM
admet-704	56	177	]	]	PUNCT
admet-704	56	178	;	;	PUNCT
admet-704	56	179	b	b	X
admet-704	56	180	reference	reference	NOUN
admet-704	56	181	[	[	X
admet-704	56	182	30	30	NUM
admet-704	56	183	]	]	PUNCT
admet-704	56	184	;	;	PUNCT
admet-704	56	185	c	c	NOUN
admet-704	56	186	calculated	calculate	VERB
admet-704	56	187	by	by	ADP
admet-704	56	188	the	the	DET
admet-704	56	189	henderson	henderson	PROPN
admet-704	56	190	-	-	PUNCT
admet-704	56	191	hasselbalch	hasselbalch	PROPN
admet-704	56	192	equation	equation	NOUN
admet-704	56	193	from	from	ADP
admet-704	56	194	the	the	DET
admet-704	56	195	reported	report	VERB
admet-704	56	196	solubility	solubility	NOUN
admet-704	56	197	value	value	NOUN
admet-704	56	198	,	,	PUNCT
admet-704	56	199	ph	ph	PROPN
admet-704	56	200	and	and	CCONJ
admet-704	56	201	pka	pka	NOUN
admet-704	56	202	;	;	PUNCT
admet-704	56	203	d	d	PRON
admet-704	56	204	measured	measure	VERB
admet-704	56	205	by	by	ADP
admet-704	56	206	μdiss	μdiss	ADJ
admet-704	56	207	profiler	profiler	NOUN
admet-704	56	208	;	;	PUNCT
admet-704	56	209	e	e	X
admet-704	56	210	not	not	PART
admet-704	56	211	applicable	applicable	ADJ
admet-704	56	212	experimental	experimental	ADJ
admet-704	56	213	materials	material	NOUN
admet-704	56	214	albendazole	albendazole	NOUN
admet-704	56	215	was	be	AUX
admet-704	56	216	purchased	purchase	VERB
admet-704	56	217	from	from	ADP
admet-704	56	218	tokyo	tokyo	PROPN
admet-704	56	219	chemical	chemical	PROPN
admet-704	56	220	industry	industry	PROPN
admet-704	56	221	co.	co.	PROPN
admet-704	56	222	,	,	PUNCT
admet-704	56	223	ltd	ltd	PROPN
admet-704	56	224	(	(	PUNCT
admet-704	56	225	tokyo	tokyo	PROPN
admet-704	56	226	,	,	PUNCT
admet-704	56	227	japan	japan	PROPN
admet-704	56	228	)	)	PUNCT
admet-704	56	229	.	.	PUNCT
admet-704	57	1	griseofulvin	griseofulvin	NOUN
admet-704	57	2	,	,	PUNCT
admet-704	57	3	dipyridamole	dipyridamole	NOUN
admet-704	57	4	,	,	PUNCT
admet-704	57	5	and	and	CCONJ
admet-704	57	6	glibenclamide	glibenclamide	NOUN
admet-704	57	7	were	be	AUX
admet-704	57	8	purchased	purchase	VERB
admet-704	57	9	from	from	ADP
admet-704	57	10	fujifilm	fujifilm	PROPN
admet-704	57	11	wako	wako	PROPN
admet-704	57	12	pure	pure	PROPN
admet-704	57	13	chemical	chemical	PROPN
admet-704	57	14	corporation	corporation	NOUN
admet-704	57	15	(	(	PUNCT
admet-704	57	16	osaka	osaka	PROPN
admet-704	57	17	,	,	PUNCT
admet-704	57	18	japan	japan	PROPN
admet-704	57	19	)	)	PUNCT
admet-704	57	20	.	.	PUNCT
admet-704	58	1	an	an	DET
admet-704	58	2	identical	identical	ADJ
admet-704	58	3	batch	batch	NOUN
admet-704	58	4	was	be	AUX
admet-704	58	5	used	use	VERB
admet-704	58	6	by	by	ADP
admet-704	58	7	all	all	DET
admet-704	58	8	companies	company	NOUN
admet-704	58	9	.	.	PUNCT
admet-704	59	1	the	the	DET
admet-704	59	2	japanese	japanese	ADJ
admet-704	59	3	pharmacopeia	pharmacopeia	NOUN
admet-704	59	4	(	(	PUNCT
admet-704	59	5	jp	jp	NOUN
admet-704	59	6	)	)	PUNCT
admet-704	59	7	2nd	2nd	ADJ
admet-704	59	8	fluid	fluid	NOUN
admet-704	59	9	for	for	ADP
admet-704	59	10	dissolution	dissolution	NOUN
admet-704	59	11	testing	testing	NOUN
admet-704	59	12	(	(	PUNCT
admet-704	59	13	12.5	12.5	NUM
admet-704	59	14	mm	mm	PROPN
admet-704	59	15	kh2po4	kh2po4	NOUN
admet-704	59	16	and	and	CCONJ
admet-704	59	17	12.5	12.5	NUM
admet-704	59	18	mm	mm	NOUN
admet-704	59	19	na2hpo4	na2hpo4	PROPN
admet-704	59	20	,	,	PUNCT
admet-704	59	21	ph	ph	X
admet-704	59	22	6.8	6.8	NUM
admet-704	59	23	,	,	PUNCT
admet-704	59	24	buffer	buffer	VERB
admet-704	59	25	capacity	capacity	NOUN
admet-704	59	26	10	10	NUM
admet-704	59	27	mm/	mm/	PROPN
admet-704	59	28	∆ph	∆ph	PROPN
admet-704	59	29	)	)	PUNCT
admet-704	59	30	was	be	AUX
admet-704	59	31	used	use	VERB
admet-704	59	32	for	for	ADP
admet-704	59	33	the	the	DET
admet-704	59	34	solubility	solubility	NOUN
admet-704	59	35	measurement	measurement	NOUN
admet-704	59	36	.	.	PUNCT
admet-704	60	1	asami	asami	PROPN
admet-704	60	2	ono	ono	PROPN
admet-704	60	3	et	et	PROPN
admet-704	60	4	.	.	PUNCT
admet-704	61	1	al	al	PROPN
admet-704	61	2	admet	admet	PROPN
admet-704	61	3	&	&	CCONJ
admet-704	61	4	dmpk	dmpk	PROPN
admet-704	61	5	7(3	7(3	NUM
admet-704	61	6	)	)	PUNCT
admet-704	61	7	(	(	PUNCT
admet-704	61	8	2019	2019	NUM
admet-704	61	9	)	)	PUNCT
admet-704	61	10	183	183	NUM
admet-704	61	11	-	-	SYM
admet-704	61	12	195	195	NUM
admet-704	61	13	186	186	NUM
admet-704	61	14	figure	figure	NOUN
admet-704	61	15	2	2	NUM
admet-704	61	16	.	.	PUNCT
admet-704	61	17	polarized	polarize	VERB
admet-704	61	18	light	light	ADJ
admet-704	61	19	microscopy	microscopy	NOUN
admet-704	61	20	images	image	NOUN
admet-704	61	21	of	of	ADP
admet-704	61	22	model	model	NOUN
admet-704	61	23	drugs	drug	NOUN
admet-704	61	24	(	(	PUNCT
admet-704	61	25	eclipse	eclipse	NOUN
admet-704	61	26	ti	ti	NOUN
admet-704	61	27	(	(	PUNCT
admet-704	61	28	nikon	nikon	PROPN
admet-704	61	29	,	,	PUNCT
admet-704	61	30	japan	japan	PROPN
admet-704	61	31	)	)	PUNCT
admet-704	61	32	)	)	PUNCT
admet-704	61	33	.	.	PUNCT
admet-704	62	1	equilibrium	equilibrium	NOUN
admet-704	62	2	solubility	solubility	NOUN
admet-704	62	3	measurement	measurement	NOUN
admet-704	62	4	by	by	ADP
admet-704	62	5	the	the	DET
admet-704	62	6	shake	shake	NOUN
admet-704	62	7	-	-	PUNCT
admet-704	62	8	flask	flask	NOUN
admet-704	62	9	method	method	NOUN
admet-704	62	10	the	the	DET
admet-704	62	11	equilibrium	equilibrium	NOUN
admet-704	62	12	solubility	solubility	NOUN
admet-704	62	13	of	of	ADP
admet-704	62	14	the	the	DET
admet-704	62	15	model	model	NOUN
admet-704	62	16	drugs	drug	NOUN
admet-704	62	17	was	be	AUX
admet-704	62	18	measured	measure	VERB
admet-704	62	19	by	by	ADP
admet-704	62	20	the	the	DET
admet-704	62	21	harmonized	harmonized	ADJ
admet-704	62	22	protocol	protocol	NOUN
admet-704	62	23	(	(	PUNCT
admet-704	62	24	hp	hp	NOUN
admet-704	62	25	)	)	PUNCT
admet-704	62	26	,	,	PUNCT
admet-704	62	27	and	and	CCONJ
admet-704	62	28	the	the	DET
admet-704	62	29	non	non	ADJ
admet-704	62	30	-	-	ADJ
admet-704	62	31	harmonized	harmonized	ADJ
admet-704	62	32	proprietary	proprietary	ADJ
admet-704	62	33	protocol	protocol	NOUN
admet-704	62	34	of	of	ADP
admet-704	62	35	each	each	DET
admet-704	62	36	company	company	NOUN
admet-704	62	37	(	(	PUNCT
admet-704	62	38	nonhp	nonhp	PROPN
admet-704	62	39	)	)	PUNCT
admet-704	62	40	.	.	PUNCT
admet-704	63	1	the	the	DET
admet-704	63	2	protocol	protocol	NOUN
admet-704	63	3	outlined	outline	VERB
admet-704	63	4	below	below	ADV
admet-704	63	5	was	be	AUX
admet-704	63	6	presented	present	VERB
admet-704	63	7	to	to	ADP
admet-704	63	8	each	each	DET
admet-704	63	9	company	company	NOUN
admet-704	63	10	as	as	ADP
admet-704	63	11	the	the	DET
admet-704	63	12	hp	hp	PROPN
admet-704	63	13	.	.	PROPN
admet-704	63	14	to	to	PART
admet-704	63	15	be	be	AUX
admet-704	63	16	viable	viable	ADJ
admet-704	63	17	at	at	ADP
admet-704	63	18	each	each	DET
admet-704	63	19	company	company	NOUN
admet-704	63	20	,	,	PUNCT
admet-704	63	21	the	the	DET
admet-704	63	22	details	detail	NOUN
admet-704	63	23	of	of	ADP
admet-704	63	24	the	the	DET
admet-704	63	25	hp	hp	PROPN
admet-704	63	26	were	be	AUX
admet-704	63	27	not	not	PART
admet-704	63	28	fully	fully	ADV
admet-704	63	29	specified	specify	VERB
admet-704	63	30	.	.	PUNCT
admet-704	64	1	the	the	DET
admet-704	64	2	solubility	solubility	NOUN
admet-704	64	3	of	of	ADP
admet-704	64	4	the	the	DET
admet-704	64	5	model	model	NOUN
admet-704	64	6	drug	drug	NOUN
admet-704	64	7	in	in	ADP
admet-704	64	8	the	the	DET
admet-704	64	9	jp	jp	NOUN
admet-704	64	10	2	2	NUM
admet-704	64	11	nd	nd	NOUN
admet-704	64	12	fluid	fluid	NOUN
admet-704	64	13	at	at	ADP
admet-704	64	14	37	37	NUM
admet-704	64	15	°	°	NUM
admet-704	64	16	c	c	NOUN
admet-704	64	17	was	be	AUX
admet-704	64	18	measured	measure	VERB
admet-704	64	19	.	.	PUNCT
admet-704	65	1	the	the	DET
admet-704	65	2	experiments	experiment	NOUN
admet-704	65	3	were	be	AUX
admet-704	65	4	performed	perform	VERB
admet-704	65	5	in	in	ADP
admet-704	65	6	triplicate	triplicate	NOUN
admet-704	65	7	.	.	PROPN
admet-704	66	1	1	1	NUM
admet-704	66	2	)	)	PUNCT
admet-704	66	3	add	add	VERB
admet-704	66	4	an	an	DET
admet-704	66	5	excess	excess	NOUN
admet-704	66	6	of	of	ADP
admet-704	66	7	a	a	DET
admet-704	66	8	drug	drug	NOUN
admet-704	66	9	to	to	ADP
admet-704	66	10	a	a	DET
admet-704	66	11	vial	vial	NOUN
admet-704	66	12	,	,	PUNCT
admet-704	66	13	then	then	ADV
admet-704	66	14	add	add	VERB
admet-704	66	15	a	a	DET
admet-704	66	16	buffer	buffer	NOUN
admet-704	66	17	solution	solution	NOUN
admet-704	66	18	(	(	PUNCT
admet-704	66	19	e.g.	e.g.	ADV
admet-704	66	20	5	5	NUM
admet-704	66	21	mg/	mg/	NOUN
admet-704	66	22	5	5	NUM
admet-704	66	23	ml	ml	NOUN
admet-704	66	24	in	in	ADP
admet-704	66	25	a	a	DET
admet-704	66	26	15	15	NUM
admet-704	66	27	ml	ml	NOUN
admet-704	66	28	vial	vial	ADJ
admet-704	66	29	)	)	PUNCT
admet-704	66	30	.	.	PUNCT
admet-704	67	1	2	2	X
admet-704	67	2	)	)	PUNCT
admet-704	67	3	after	after	ADP
admet-704	67	4	stirring	stir	VERB
admet-704	67	5	for	for	ADP
admet-704	67	6	1	1	NUM
admet-704	67	7	min	min	NOUN
admet-704	67	8	with	with	ADP
admet-704	67	9	a	a	DET
admet-704	67	10	vortex	vortex	NOUN
admet-704	67	11	mixer	mixer	NOUN
admet-704	67	12	,	,	PUNCT
admet-704	67	13	shake	shake	VERB
admet-704	67	14	the	the	DET
admet-704	67	15	sample	sample	NOUN
admet-704	67	16	vigorously	vigorously	ADV
admet-704	67	17	at	at	ADP
admet-704	67	18	37	37	NUM
admet-704	67	19	°	°	NOUN
admet-704	67	20	c	c	NOUN
admet-704	67	21	for	for	ADP
admet-704	67	22	24	24	NUM
admet-704	67	23	h	h	NOUN
admet-704	67	24	with	with	ADP
admet-704	67	25	light	light	ADJ
admet-704	67	26	shielding	shielding	NOUN
admet-704	67	27	.	.	PUNCT
admet-704	68	1	if	if	SCONJ
admet-704	68	2	possible	possible	ADJ
admet-704	68	3	,	,	PUNCT
admet-704	68	4	measure	measure	VERB
admet-704	68	5	the	the	DET
admet-704	68	6	concentration	concentration	NOUN
admet-704	68	7	-	-	PUNCT
admet-704	68	8	time	time	NOUN
admet-704	68	9	profile1	profile1	PROPN
admet-704	68	10	.	.	PROPN
admet-704	68	11	3	3	X
admet-704	68	12	)	)	PUNCT
admet-704	68	13	let	let	AUX
admet-704	68	14	stand	stand	VERB
admet-704	68	15	for	for	ADP
admet-704	68	16	a	a	DET
admet-704	68	17	few	few	ADJ
admet-704	68	18	minutes	minute	NOUN
admet-704	68	19	to	to	ADP
admet-704	68	20	sediment	sediment	NOUN
admet-704	68	21	solids	solid	NOUN
admet-704	68	22	.	.	PUNCT
admet-704	69	1	4	4	NUM
admet-704	69	2	)	)	PUNCT
admet-704	69	3	filter	filter	NOUN
admet-704	69	4	the	the	DET
admet-704	69	5	supernatant	supernatant	NOUN
admet-704	69	6	,	,	PUNCT
admet-704	69	7	discarding	discard	VERB
admet-704	69	8	the	the	DET
admet-704	69	9	first	first	ADJ
admet-704	69	10	few	few	ADJ
admet-704	69	11	portions	portion	NOUN
admet-704	69	12	(	(	PUNCT
admet-704	69	13	e.g.	e.g.	ADV
admet-704	69	14	,	,	PUNCT
admet-704	69	15	0.1	0.1	NUM
admet-704	69	16	ml	ml	NOUN
admet-704	69	17	for	for	ADP
admet-704	69	18	4	4	NUM
admet-704	69	19	mm	mm	PROPN
admet-704	69	20	diameter	diameter	NOUN
admet-704	69	21	filter	filter	NOUN
admet-704	69	22	)	)	PUNCT
admet-704	69	23	.	.	PUNCT
admet-704	70	1	select	select	VERB
admet-704	70	2	an	an	DET
admet-704	70	3	appropriate	appropriate	ADJ
admet-704	70	4	filter	filter	NOUN
admet-704	70	5	material	material	NOUN
admet-704	70	6	.	.	PUNCT
admet-704	71	1	if	if	SCONJ
admet-704	71	2	possible	possible	ADJ
admet-704	71	3	,	,	PUNCT
admet-704	71	4	pre	pre	ADJ
admet-704	71	5	-	-	VERB
admet-704	71	6	heat	heat	VERB
admet-704	71	7	the	the	DET
admet-704	71	8	filter	filter	NOUN
admet-704	71	9	and	and	CCONJ
admet-704	71	10	syringe	syringe	NOUN
admet-704	71	11	to	to	ADP
admet-704	71	12	37	37	NUM
admet-704	71	13	°	°	NOUN
admet-704	71	14	c	c	NOUN
admet-704	71	15	before	before	ADP
admet-704	71	16	use	use	NOUN
admet-704	71	17	.	.	PUNCT
admet-704	72	1	5	5	X
admet-704	72	2	)	)	PUNCT
admet-704	72	3	dilute	dilute	VERB
admet-704	72	4	the	the	DET
admet-704	72	5	filtrate	filtrate	NOUN
admet-704	72	6	as	as	ADP
admet-704	72	7	necessary	necessary	ADJ
admet-704	72	8	.	.	PUNCT
admet-704	73	1	if	if	SCONJ
admet-704	73	2	possible	possible	ADJ
admet-704	73	3	,	,	PUNCT
admet-704	73	4	to	to	PART
admet-704	73	5	avoid	avoid	VERB
admet-704	73	6	adsorption	adsorption	NOUN
admet-704	73	7	,	,	PUNCT
admet-704	73	8	pre	pre	ADJ
admet-704	73	9	-	-	VERB
admet-704	73	10	treat	treat	VERB
admet-704	73	11	a	a	DET
admet-704	73	12	tip	tip	NOUN
admet-704	73	13	with	with	ADP
admet-704	73	14	the	the	DET
admet-704	73	15	filtrate	filtrate	NOUN
admet-704	73	16	,	,	PUNCT
admet-704	73	17	add	add	VERB
admet-704	73	18	a	a	DET
admet-704	73	19	surfactant	surfactant	NOUN
admet-704	73	20	(	(	PUNCT
admet-704	73	21	a	a	DET
admet-704	73	22	few	few	ADJ
admet-704	73	23	microliters	microliter	NOUN
admet-704	73	24	)	)	PUNCT
admet-704	73	25	to	to	ADP
admet-704	73	26	the	the	DET
admet-704	73	27	filtrate	filtrate	NOUN
admet-704	73	28	,	,	PUNCT
admet-704	73	29	and/or	and/or	CCONJ
admet-704	73	30	rinse	rinse	VERB
admet-704	73	31	the	the	DET
admet-704	73	32	tip	tip	NOUN
admet-704	73	33	with	with	ADP
admet-704	73	34	an	an	DET
admet-704	73	35	organic	organic	ADJ
admet-704	73	36	solvent	solvent	NOUN
admet-704	73	37	.	.	PUNCT
admet-704	74	1	6	6	NUM
admet-704	74	2	)	)	PUNCT
admet-704	74	3	measure	measure	NOUN
admet-704	74	4	the	the	DET
admet-704	74	5	final	final	ADJ
admet-704	74	6	ph	ph	NOUN
admet-704	74	7	.	.	NOUN
admet-704	74	8	7	7	NUM
admet-704	74	9	)	)	PUNCT
admet-704	74	10	measure	measure	VERB
admet-704	74	11	the	the	DET
admet-704	74	12	concentration	concentration	NOUN
admet-704	74	13	of	of	ADP
admet-704	74	14	a	a	DET
admet-704	74	15	drug	drug	NOUN
admet-704	74	16	by	by	ADP
admet-704	74	17	an	an	DET
admet-704	74	18	appropriate	appropriate	ADJ
admet-704	74	19	method	method	NOUN
admet-704	74	20	(	(	PUNCT
admet-704	74	21	e.g.	e.g.	ADV
admet-704	74	22	uv	uv	NOUN
admet-704	74	23	-	-	PUNCT
admet-704	74	24	vis	vis	X
admet-704	74	25	,	,	PUNCT
admet-704	74	26	hplc	hplc	NOUN
admet-704	74	27	/	/	SYM
admet-704	74	28	uv	uv	NOUN
admet-704	74	29	-	-	PUNCT
admet-704	74	30	vis	vis	X
admet-704	74	31	,	,	PUNCT
admet-704	74	32	or	or	CCONJ
admet-704	74	33	lcms	lcms	PROPN
admet-704	74	34	)	)	PUNCT
admet-704	74	35	.	.	PUNCT
admet-704	75	1	8)	8)	NUM
admet-704	75	2	if	if	SCONJ
admet-704	75	3	possible	possible	ADJ
admet-704	75	4	,	,	PUNCT
admet-704	75	5	analyse	analyse	VERB
admet-704	75	6	the	the	DET
admet-704	75	7	initial	initial	ADJ
admet-704	75	8	and	and	CCONJ
admet-704	75	9	residual	residual	ADJ
admet-704	75	10	solids	solid	NOUN
admet-704	75	11	by	by	ADP
admet-704	75	12	powder	powder	NOUN
admet-704	75	13	x	x	NOUN
admet-704	75	14	-	-	NOUN
admet-704	75	15	ray	ray	NOUN
admet-704	75	16	diffraction	diffraction	NOUN
admet-704	75	17	(	(	PUNCT
admet-704	75	18	pxrd)1	pxrd)1	NOUN
admet-704	75	19	.	.	NOUN
admet-704	75	20	1	1	NUM
admet-704	75	21	either	either	CCONJ
admet-704	75	22	a	a	DET
admet-704	75	23	pxrd	pxrd	NOUN
admet-704	75	24	measurement	measurement	NOUN
admet-704	75	25	or	or	CCONJ
admet-704	75	26	a	a	DET
admet-704	75	27	concentration	concentration	NOUN
admet-704	75	28	-	-	PUNCT
admet-704	75	29	time	time	NOUN
admet-704	75	30	profile	profile	NOUN
admet-704	75	31	measurement	measurement	NOUN
admet-704	75	32	is	be	AUX
admet-704	75	33	required	require	VERB
admet-704	75	34	.	.	PUNCT
admet-704	76	1	admet	admet	PROPN
admet-704	76	2	&	&	CCONJ
admet-704	76	3	dmpk	dmpk	PROPN
admet-704	76	4	7(3	7(3	NUM
admet-704	76	5	)	)	PUNCT
admet-704	76	6	(	(	PUNCT
admet-704	76	7	2019	2019	NUM
admet-704	76	8	)	)	PUNCT
admet-704	76	9	183	183	NUM
admet-704	76	10	-	-	SYM
admet-704	76	11	195	195	NUM
admet-704	76	12	harmonizing	harmonize	VERB
admet-704	76	13	solubility	solubility	NOUN
admet-704	76	14	measurement	measurement	NOUN
admet-704	76	15	to	to	PART
admet-704	76	16	lower	lower	VERB
admet-704	76	17	inter	inter	ADJ
admet-704	76	18	-	-	ADJ
admet-704	76	19	laboratory	laboratory	ADJ
admet-704	76	20	variance	variance	NOUN
admet-704	76	21	doi	doi	NOUN
admet-704	76	22	:	:	PUNCT
admet-704	76	23	10.5599	10.5599	NUM
admet-704	76	24	/	/	SYM
admet-704	76	25	admet.704	admet.704	NOUN
admet-704	76	26	187	187	NUM
admet-704	76	27	solubility	solubility	NOUN
admet-704	76	28	measurement	measurement	NOUN
admet-704	76	29	by	by	ADP
admet-704	76	30	μdiss	μdiss	ADJ
admet-704	76	31	profiler	profiler	NOUN
admet-704	77	1	the	the	DET
admet-704	77	2	solubility	solubility	NOUN
admet-704	77	3	of	of	ADP
admet-704	77	4	the	the	DET
admet-704	77	5	model	model	NOUN
admet-704	77	6	drugs	drug	NOUN
admet-704	77	7	was	be	AUX
admet-704	77	8	also	also	ADV
admet-704	77	9	measured	measure	VERB
admet-704	77	10	with	with	ADP
admet-704	77	11	a	a	DET
admet-704	77	12	µdiss	µdiss	NOUN
admet-704	77	13	profiler	profiler	NOUN
admet-704	77	14	™	™	ADJ
admet-704	77	15	instrument	instrument	NOUN
admet-704	77	16	(	(	PUNCT
admet-704	77	17	pion	pion	PROPN
admet-704	77	18	inc	inc	PROPN
admet-704	77	19	)	)	PUNCT
admet-704	77	20	by	by	ADP
admet-704	77	21	company	company	NOUN
admet-704	77	22	f.	f.	PROPN
admet-704	77	23	this	this	DET
admet-704	77	24	instrument	instrument	NOUN
admet-704	77	25	employs	employ	VERB
admet-704	77	26	eight	eight	NUM
admet-704	77	27	fibre	fibre	NOUN
admet-704	77	28	-	-	PUNCT
admet-704	77	29	optic	optic	NOUN
admet-704	77	30	dip	dip	NOUN
admet-704	77	31	probes	probe	NOUN
admet-704	77	32	,	,	PUNCT
admet-704	77	33	each	each	PRON
admet-704	77	34	with	with	ADP
admet-704	77	35	its	its	PRON
admet-704	77	36	own	own	ADJ
admet-704	77	37	dedicated	dedicated	ADJ
admet-704	77	38	photodiode	photodiode	NOUN
admet-704	77	39	array	array	NOUN
admet-704	77	40	spectrometer	spectrometer	NOUN
admet-704	78	1	[	[	X
admet-704	78	2	39	39	NUM
admet-704	78	3	]	]	PUNCT
admet-704	78	4	.	.	PUNCT
admet-704	79	1	an	an	DET
admet-704	79	2	excess	excess	NOUN
admet-704	79	3	of	of	ADP
admet-704	79	4	a	a	DET
admet-704	79	5	model	model	NOUN
admet-704	79	6	drug	drug	NOUN
admet-704	79	7	and	and	CCONJ
admet-704	79	8	20	20	NUM
admet-704	79	9	ml	ml	NOUN
admet-704	79	10	of	of	ADP
admet-704	79	11	a	a	DET
admet-704	79	12	buffer	buffer	NOUN
admet-704	79	13	solution	solution	NOUN
admet-704	79	14	pre	pre	ADJ
admet-704	79	15	-	-	ADJ
admet-704	79	16	heated	heated	ADJ
admet-704	79	17	to	to	ADP
admet-704	79	18	37	37	NUM
admet-704	79	19	°	°	NOUN
admet-704	79	20	c	c	NOUN
admet-704	79	21	were	be	AUX
admet-704	79	22	added	add	VERB
admet-704	79	23	to	to	ADP
admet-704	79	24	the	the	DET
admet-704	79	25	vessels	vessel	NOUN
admet-704	79	26	and	and	CCONJ
admet-704	79	27	stirred	stir	VERB
admet-704	79	28	at	at	ADP
admet-704	79	29	37	37	NUM
admet-704	79	30	°	°	NOUN
admet-704	79	31	c	c	NOUN
admet-704	79	32	for	for	ADP
admet-704	79	33	24	24	NUM
admet-704	79	34	h.	h.	NOUN
admet-704	79	35	the	the	DET
admet-704	79	36	concentration	concentration	NOUN
admet-704	79	37	of	of	ADP
admet-704	79	38	the	the	DET
admet-704	79	39	model	model	NOUN
admet-704	79	40	drug	drug	NOUN
admet-704	79	41	was	be	AUX
admet-704	79	42	measured	measure	VERB
admet-704	79	43	by	by	ADP
admet-704	79	44	in	in	ADP
admet-704	79	45	situ	situ	ADJ
admet-704	79	46	uv	uv	NOUN
admet-704	79	47	probes	probe	NOUN
admet-704	79	48	(	(	PUNCT
admet-704	79	49	wave	wave	NOUN
admet-704	79	50	length	length	NOUN
admet-704	79	51	270	270	NUM
admet-704	79	52	-	-	SYM
admet-704	79	53	280	280	NUM
admet-704	79	54	nm	nm	NOUN
admet-704	79	55	for	for	ADP
admet-704	79	56	albendazole	albendazole	ADJ
admet-704	79	57	,	,	PUNCT
admet-704	79	58	griseofulvin	griseofulvin	NOUN
admet-704	79	59	,	,	PUNCT
admet-704	79	60	dipyridamole	dipyridamole	NOUN
admet-704	79	61	,	,	PUNCT
admet-704	79	62	and	and	CCONJ
admet-704	79	63	250	250	NUM
admet-704	79	64	-	-	SYM
admet-704	79	65	265	265	NUM
admet-704	79	66	nm	nm	NOUN
admet-704	79	67	for	for	ADP
admet-704	79	68	glibenclamide	glibenclamide	NOUN
admet-704	79	69	)	)	PUNCT
admet-704	79	70	.	.	PUNCT
admet-704	80	1	the	the	DET
admet-704	80	2	experiments	experiment	NOUN
admet-704	80	3	were	be	AUX
admet-704	80	4	performed	perform	VERB
admet-704	80	5	in	in	ADP
admet-704	80	6	duplicate	duplicate	NOUN
admet-704	80	7	.	.	PUNCT
admet-704	81	1	results	result	NOUN
admet-704	81	2	and	and	CCONJ
admet-704	81	3	discussion	discussion	NOUN
admet-704	81	4	harmonizing	harmonize	VERB
admet-704	81	5	the	the	DET
admet-704	81	6	protocol	protocol	NOUN
admet-704	81	7	for	for	ADP
admet-704	81	8	equilibrium	equilibrium	NOUN
admet-704	81	9	solubility	solubility	NOUN
admet-704	81	10	measurements	measurement	NOUN
admet-704	81	11	by	by	ADP
admet-704	81	12	the	the	DET
admet-704	81	13	shake	shake	NOUN
admet-704	81	14	-	-	PUNCT
admet-704	81	15	flask	flask	NOUN
admet-704	81	16	method	method	NOUN
admet-704	81	17	consensus	consensus	NOUN
admet-704	81	18	recommendations	recommendation	NOUN
admet-704	81	19	about	about	ADP
admet-704	81	20	the	the	DET
admet-704	81	21	shake	shake	NOUN
admet-704	81	22	flask	flask	NOUN
admet-704	81	23	method	method	NOUN
admet-704	81	24	have	have	AUX
admet-704	81	25	been	be	AUX
admet-704	81	26	summarized	summarize	VERB
admet-704	81	27	by	by	ADP
admet-704	81	28	avdeef	avdeef	PROPN
admet-704	81	29	et	et	PROPN
admet-704	81	30	al	al	PROPN
admet-704	81	31	.	.	PUNCT
admet-704	82	1	[	[	X
admet-704	82	2	28	28	NUM
admet-704	82	3	]	]	PUNCT
admet-704	82	4	.	.	PUNCT
admet-704	83	1	however	however	ADV
admet-704	83	2	,	,	PUNCT
admet-704	83	3	since	since	SCONJ
admet-704	83	4	every	every	DET
admet-704	83	5	company	company	NOUN
admet-704	83	6	has	have	VERB
admet-704	83	7	its	its	PRON
admet-704	83	8	own	own	ADJ
admet-704	83	9	situation	situation	NOUN
admet-704	83	10	,	,	PUNCT
admet-704	83	11	it	it	PRON
admet-704	83	12	may	may	AUX
admet-704	83	13	not	not	PART
admet-704	83	14	be	be	AUX
admet-704	83	15	practical	practical	ADJ
admet-704	83	16	to	to	PART
admet-704	83	17	pay	pay	VERB
admet-704	83	18	equal	equal	ADJ
admet-704	83	19	attention	attention	NOUN
admet-704	83	20	to	to	ADP
admet-704	83	21	every	every	DET
admet-704	83	22	recommendation	recommendation	NOUN
admet-704	83	23	.	.	PUNCT
admet-704	84	1	therefore	therefore	ADV
admet-704	84	2	,	,	PUNCT
admet-704	84	3	we	we	PRON
admet-704	84	4	first	first	ADV
admet-704	84	5	divided	divide	VERB
admet-704	84	6	the	the	DET
admet-704	84	7	recommendations	recommendation	NOUN
admet-704	84	8	into	into	ADP
admet-704	84	9	two	two	NUM
admet-704	84	10	categories	category	NOUN
admet-704	84	11	,	,	PUNCT
admet-704	84	12	“	"	PUNCT
admet-704	84	13	mandatory	mandatory	ADJ
admet-704	84	14	”	"	PUNCT
admet-704	84	15	and	and	CCONJ
admet-704	84	16	“	"	PUNCT
admet-704	84	17	recommended	recommend	VERB
admet-704	84	18	”	"	PUNCT
admet-704	84	19	,	,	PUNCT
admet-704	84	20	including	include	VERB
admet-704	84	21	a	a	DET
admet-704	84	22	few	few	ADJ
admet-704	84	23	additional	additional	ADJ
admet-704	84	24	recommendations	recommendation	NOUN
admet-704	84	25	based	base	VERB
admet-704	84	26	on	on	ADP
admet-704	84	27	their	their	PRON
admet-704	84	28	possible	possible	ADJ
admet-704	84	29	impact	impact	NOUN
admet-704	84	30	on	on	ADP
admet-704	84	31	solubility	solubility	NOUN
admet-704	84	32	data	datum	NOUN
admet-704	84	33	.	.	PUNCT
admet-704	85	1	we	we	PRON
admet-704	85	2	then	then	ADV
admet-704	85	3	embodied	embody	VERB
admet-704	85	4	these	these	DET
admet-704	85	5	mandatory	mandatory	ADJ
admet-704	85	6	and	and	CCONJ
admet-704	85	7	recommended	recommended	ADJ
admet-704	85	8	items	item	NOUN
admet-704	85	9	as	as	ADP
admet-704	85	10	a	a	DET
admet-704	85	11	harmonized	harmonized	ADJ
admet-704	85	12	protocol	protocol	NOUN
admet-704	85	13	.	.	PUNCT
admet-704	86	1	mandatory	mandatory	ADJ
admet-704	86	2	agitation	agitation	NOUN
admet-704	86	3	.	.	PUNCT
admet-704	87	1	sufficient	sufficient	ADJ
admet-704	87	2	agitation	agitation	NOUN
admet-704	87	3	should	should	AUX
admet-704	87	4	be	be	AUX
admet-704	87	5	applied	apply	VERB
admet-704	87	6	to	to	PART
admet-704	87	7	firmly	firmly	ADV
admet-704	87	8	wet	wet	ADJ
admet-704	87	9	and	and	CCONJ
admet-704	87	10	suspend	suspend	VERB
admet-704	87	11	drug	drug	NOUN
admet-704	87	12	particles	particle	NOUN
admet-704	87	13	.	.	PUNCT
admet-704	88	1	poor	poor	ADJ
admet-704	88	2	wettability	wettability	NOUN
admet-704	88	3	can	can	AUX
admet-704	88	4	often	often	ADV
admet-704	88	5	be	be	AUX
admet-704	88	6	a	a	DET
admet-704	88	7	problem	problem	NOUN
admet-704	88	8	for	for	ADP
admet-704	88	9	poorly	poorly	ADV
admet-704	88	10	water	water	NOUN
admet-704	88	11	-	-	PUNCT
admet-704	88	12	soluble	soluble	ADJ
admet-704	88	13	drugs	drug	NOUN
admet-704	88	14	.	.	PUNCT
admet-704	89	1	sonication	sonication	NOUN
admet-704	89	2	is	be	AUX
admet-704	89	3	not	not	PART
admet-704	89	4	recommended	recommend	VERB
admet-704	89	5	as	as	SCONJ
admet-704	89	6	it	it	PRON
admet-704	89	7	can	can	AUX
admet-704	89	8	promote	promote	VERB
admet-704	89	9	aggregation	aggregation	NOUN
admet-704	89	10	of	of	ADP
admet-704	89	11	solids	solid	NOUN
admet-704	89	12	[	[	X
admet-704	89	13	28	28	NUM
admet-704	89	14	]	]	PUNCT
admet-704	89	15	.	.	PUNCT
admet-704	90	1	incubation	incubation	NOUN
admet-704	90	2	temperature	temperature	NOUN
admet-704	90	3	.	.	PUNCT
admet-704	91	1	the	the	DET
admet-704	91	2	temperature	temperature	NOUN
admet-704	91	3	must	must	AUX
admet-704	91	4	be	be	AUX
admet-704	91	5	controlled	control	VERB
admet-704	91	6	.	.	PUNCT
admet-704	92	1	solubility	solubility	NOUN
admet-704	92	2	can	can	AUX
admet-704	92	3	vary	vary	VERB
admet-704	92	4	depending	depend	VERB
admet-704	92	5	on	on	ADP
admet-704	92	6	the	the	DET
admet-704	92	7	drug	drug	NOUN
admet-704	92	8	,	,	PUNCT
admet-704	92	9	by	by	ADP
admet-704	92	10	a	a	DET
admet-704	92	11	factor	factor	NOUN
admet-704	92	12	of	of	ADP
admet-704	92	13	0.4	0.4	NUM
admet-704	92	14	(	(	PUNCT
admet-704	92	15	e.g.	e.g.	ADV
admet-704	92	16	,	,	PUNCT
admet-704	92	17	erythromycin	erythromycin	NOUN
admet-704	92	18	)	)	PUNCT
admet-704	92	19	to	to	ADP
admet-704	92	20	6.5	6.5	NUM
admet-704	92	21	(	(	PUNCT
admet-704	92	22	e.g.	e.g.	ADV
admet-704	92	23	,	,	PUNCT
admet-704	92	24	triflupromazine	triflupromazine	NOUN
admet-704	92	25	)	)	PUNCT
admet-704	92	26	between	between	ADP
admet-704	92	27	25	25	NUM
admet-704	92	28	°	°	NOUN
admet-704	92	29	c	c	NOUN
admet-704	92	30	and	and	CCONJ
admet-704	92	31	37	37	NUM
admet-704	92	32	°	°	NOUN
admet-704	92	33	c	c	NOUN
admet-704	92	34	[	[	X
admet-704	92	35	40	40	NUM
admet-704	92	36	]	]	PUNCT
admet-704	92	37	.	.	PUNCT
admet-704	93	1	incubation	incubation	NOUN
admet-704	93	2	time	time	NOUN
admet-704	93	3	.	.	PUNCT
admet-704	94	1	the	the	DET
admet-704	94	2	incubation	incubation	NOUN
admet-704	94	3	time	time	NOUN
admet-704	94	4	should	should	AUX
admet-704	94	5	be	be	AUX
admet-704	94	6	set	set	VERB
admet-704	94	7	to	to	ADP
admet-704	94	8	>	>	SYM
admet-704	94	9	24	24	NUM
admet-704	94	10	h	h	NOUN
admet-704	94	11	to	to	PART
admet-704	94	12	achieve	achieve	VERB
admet-704	94	13	equilibrium	equilibrium	NOUN
admet-704	95	1	[	[	X
admet-704	95	2	28,41	28,41	NUM
admet-704	95	3	-	-	SYM
admet-704	95	4	43	43	NUM
admet-704	95	5	]	]	PUNCT
admet-704	95	6	.	.	PUNCT
admet-704	96	1	if	if	SCONJ
admet-704	96	2	possible	possible	ADJ
admet-704	96	3	,	,	PUNCT
admet-704	96	4	the	the	DET
admet-704	96	5	concentration	concentration	NOUN
admet-704	96	6	should	should	AUX
admet-704	96	7	be	be	AUX
admet-704	96	8	measured	measure	VERB
admet-704	96	9	over	over	ADP
admet-704	96	10	time	time	NOUN
admet-704	96	11	to	to	PART
admet-704	96	12	ensure	ensure	VERB
admet-704	96	13	achieving	achieve	VERB
admet-704	96	14	equilibrium	equilibrium	NOUN
admet-704	96	15	,	,	PUNCT
admet-704	96	16	for	for	ADP
admet-704	96	17	example	example	NOUN
admet-704	96	18	at	at	ADP
admet-704	96	19	1	1	NUM
admet-704	96	20	,	,	PUNCT
admet-704	96	21	6	6	NUM
admet-704	96	22	,	,	PUNCT
admet-704	96	23	and	and	CCONJ
admet-704	96	24	24	24	NUM
admet-704	96	25	h	h	NOUN
admet-704	97	1	[	[	X
admet-704	97	2	24	24	NUM
admet-704	97	3	]	]	PUNCT
admet-704	97	4	.	.	PUNCT
admet-704	98	1	filtration	filtration	NOUN
admet-704	98	2	.	.	PUNCT
admet-704	99	1	lipophilic	lipophilic	ADJ
admet-704	99	2	drugs	drug	NOUN
admet-704	99	3	tend	tend	VERB
admet-704	99	4	to	to	PART
admet-704	99	5	adsorb	adsorb	VERB
admet-704	99	6	to	to	ADP
admet-704	99	7	the	the	DET
admet-704	99	8	filter	filter	NOUN
admet-704	99	9	material	material	NOUN
admet-704	100	1	[	[	X
admet-704	100	2	44,45,46	44,45,46	NOUN
admet-704	100	3	]	]	PUNCT
admet-704	100	4	.	.	PUNCT
admet-704	101	1	a	a	DET
admet-704	101	2	hydrophilic	hydrophilic	ADJ
admet-704	101	3	type	type	NOUN
admet-704	101	4	filter	filter	NOUN
admet-704	101	5	(	(	PUNCT
admet-704	101	6	e.g.	e.g.	ADV
admet-704	101	7	,	,	PUNCT
admet-704	101	8	hydrophilic	hydrophilic	ADJ
admet-704	101	9	pvdf	pvdf	PROPN
admet-704	101	10	and	and	CCONJ
admet-704	101	11	pes	pes	PROPN
admet-704	101	12	)	)	PUNCT
admet-704	101	13	is	be	AUX
admet-704	101	14	recommended	recommend	VERB
admet-704	101	15	for	for	ADP
admet-704	101	16	unionized	unionized	ADJ
admet-704	101	17	species	specie	NOUN
admet-704	101	18	[	[	X
admet-704	101	19	28	28	NUM
admet-704	101	20	]	]	PUNCT
admet-704	101	21	.	.	PUNCT
admet-704	102	1	the	the	DET
admet-704	102	2	first	first	ADJ
admet-704	102	3	few	few	ADJ
admet-704	102	4	portions	portion	NOUN
admet-704	102	5	of	of	ADP
admet-704	102	6	a	a	DET
admet-704	102	7	filtrate	filtrate	NOUN
admet-704	102	8	must	must	AUX
admet-704	102	9	be	be	AUX
admet-704	102	10	discarded	discard	VERB
admet-704	102	11	to	to	PART
admet-704	102	12	pre	pre	VERB
admet-704	102	13	-	-	VERB
admet-704	102	14	saturate	saturate	VERB
admet-704	102	15	the	the	DET
admet-704	102	16	filter	filter	NOUN
admet-704	102	17	.	.	PUNCT
admet-704	103	1	pipetting	pipetting	NOUN
admet-704	103	2	.	.	PUNCT
admet-704	104	1	lipophilic	lipophilic	ADJ
admet-704	104	2	drugs	drug	NOUN
admet-704	104	3	tend	tend	VERB
admet-704	104	4	to	to	PART
admet-704	104	5	adsorb	adsorb	VERB
admet-704	104	6	to	to	ADP
admet-704	104	7	a	a	DET
admet-704	104	8	pipet	pipet	NOUN
admet-704	104	9	tip	tip	NOUN
admet-704	104	10	and	and	CCONJ
admet-704	104	11	vial	vial	ADJ
admet-704	104	12	materials	material	NOUN
admet-704	104	13	[	[	X
admet-704	104	14	47,48	47,48	NOUN
admet-704	104	15	]	]	PUNCT
admet-704	104	16	.	.	PUNCT
admet-704	105	1	to	to	PART
admet-704	105	2	avoid	avoid	VERB
admet-704	105	3	adsorption	adsorption	NOUN
admet-704	105	4	,	,	PUNCT
admet-704	105	5	pipet	pipet	NOUN
admet-704	105	6	tips	tip	NOUN
admet-704	105	7	can	can	AUX
admet-704	105	8	be	be	AUX
admet-704	105	9	pre	pre	VERB
admet-704	105	10	-	-	VERB
admet-704	105	11	treated	treat	VERB
admet-704	105	12	by	by	ADP
admet-704	105	13	the	the	DET
admet-704	105	14	filtrate	filtrate	NOUN
admet-704	105	15	solution	solution	NOUN
admet-704	105	16	.	.	PUNCT
admet-704	106	1	addition	addition	NOUN
admet-704	106	2	of	of	ADP
admet-704	106	3	a	a	DET
admet-704	106	4	drop	drop	NOUN
admet-704	106	5	of	of	ADP
admet-704	106	6	surfactant	surfactant	NOUN
admet-704	106	7	is	be	AUX
admet-704	106	8	also	also	ADV
admet-704	106	9	effective	effective	ADJ
admet-704	106	10	for	for	ADP
admet-704	106	11	preventing	prevent	VERB
admet-704	106	12	adsorption	adsorption	NOUN
admet-704	106	13	.	.	PUNCT
admet-704	107	1	after	after	ADP
admet-704	107	2	pipetting	pipetting	NOUN
admet-704	107	3	,	,	PUNCT
admet-704	107	4	the	the	DET
admet-704	107	5	tip	tip	NOUN
admet-704	107	6	can	can	AUX
admet-704	107	7	be	be	AUX
admet-704	107	8	rinsed	rinse	VERB
admet-704	107	9	with	with	ADP
admet-704	107	10	an	an	DET
admet-704	107	11	organic	organic	ADJ
admet-704	107	12	solvent	solvent	NOUN
admet-704	107	13	.	.	PUNCT
admet-704	108	1	final	final	ADJ
admet-704	108	2	ph	ph	PROPN
admet-704	108	3	.	.	PUNCT
admet-704	109	1	the	the	DET
admet-704	109	2	ph	ph	NOUN
admet-704	109	3	value	value	NOUN
admet-704	109	4	can	can	AUX
admet-704	109	5	change	change	VERB
admet-704	109	6	during	during	ADP
admet-704	109	7	solubility	solubility	NOUN
admet-704	109	8	measurements	measurement	NOUN
admet-704	109	9	for	for	ADP
admet-704	109	10	ionizable	ionizable	ADJ
admet-704	109	11	drugs	drug	NOUN
admet-704	109	12	,	,	PUNCT
admet-704	109	13	especially	especially	ADV
admet-704	109	14	when	when	SCONJ
admet-704	109	15	a	a	DET
admet-704	109	16	large	large	ADJ
admet-704	109	17	excess	excess	NOUN
admet-704	109	18	of	of	ADP
admet-704	109	19	an	an	DET
admet-704	109	20	ionizable	ionizable	ADJ
admet-704	109	21	drug	drug	NOUN
admet-704	109	22	is	be	AUX
admet-704	109	23	added	add	VERB
admet-704	109	24	in	in	ADP
admet-704	109	25	a	a	DET
admet-704	109	26	salt	salt	NOUN
admet-704	109	27	form	form	NOUN
admet-704	109	28	.	.	PUNCT
admet-704	110	1	solid	solid	ADJ
admet-704	110	2	state	state	NOUN
admet-704	110	3	characterization	characterization	NOUN
admet-704	110	4	.	.	PUNCT
admet-704	111	1	the	the	DET
admet-704	111	2	initial	initial	ADJ
admet-704	111	3	form	form	NOUN
admet-704	111	4	may	may	AUX
admet-704	111	5	transform	transform	VERB
admet-704	111	6	to	to	ADP
admet-704	111	7	a	a	DET
admet-704	111	8	more	more	ADV
admet-704	111	9	stable	stable	ADJ
admet-704	111	10	form	form	NOUN
admet-704	111	11	,	,	PUNCT
admet-704	111	12	a	a	DET
admet-704	111	13	free	free	ADJ
admet-704	111	14	form	form	NOUN
admet-704	111	15	,	,	PUNCT
admet-704	111	16	a	a	DET
admet-704	111	17	hydrate	hydrate	NOUN
admet-704	111	18	,	,	PUNCT
admet-704	111	19	etc	etc	X
admet-704	111	20	.	.	X
admet-704	111	21	during	during	ADP
admet-704	111	22	solubility	solubility	NOUN
admet-704	111	23	measurements	measurement	NOUN
admet-704	111	24	.	.	PUNCT
admet-704	112	1	the	the	DET
admet-704	112	2	solid	solid	ADJ
admet-704	112	3	forms	form	NOUN
admet-704	112	4	of	of	ADP
admet-704	112	5	the	the	DET
admet-704	112	6	initial	initial	ADJ
admet-704	112	7	solids	solid	NOUN
admet-704	112	8	and	and	CCONJ
admet-704	112	9	the	the	DET
admet-704	112	10	residual	residual	ADJ
admet-704	112	11	solids	solid	NOUN
admet-704	112	12	after	after	SCONJ
admet-704	112	13	solubility	solubility	NOUN
admet-704	112	14	measurements	measurement	NOUN
admet-704	112	15	(	(	PUNCT
admet-704	112	16	equilibrium	equilibrium	NOUN
admet-704	112	17	maker	maker	NOUN
admet-704	112	18	)	)	PUNCT
admet-704	112	19	should	should	AUX
admet-704	112	20	be	be	AUX
admet-704	112	21	characterized	characterize	VERB
admet-704	112	22	by	by	ADP
admet-704	112	23	pxrd	pxrd	NOUN
admet-704	112	24	,	,	PUNCT
admet-704	112	25	differential	differential	NOUN
admet-704	112	26	scanning	scanning	NOUN
admet-704	112	27	calorimetry	calorimetry	NOUN
admet-704	112	28	,	,	PUNCT
admet-704	112	29	raman	raman	NOUN
admet-704	112	30	spectra	spectra	NOUN
admet-704	112	31	,	,	PUNCT
admet-704	112	32	etc	etc	X
admet-704	112	33	.	.	X
admet-704	112	34	recommended	recommend	VERB
admet-704	112	35	filtration	filtration	NOUN
admet-704	112	36	temperature	temperature	NOUN
admet-704	112	37	.	.	PUNCT
admet-704	113	1	to	to	PART
admet-704	113	2	maintain	maintain	VERB
admet-704	113	3	the	the	DET
admet-704	113	4	temperature	temperature	NOUN
admet-704	113	5	of	of	ADP
admet-704	113	6	an	an	DET
admet-704	113	7	equilibrated	equilibrate	VERB
admet-704	113	8	solution	solution	NOUN
admet-704	113	9	during	during	ADP
admet-704	113	10	filtration	filtration	NOUN
admet-704	113	11	,	,	PUNCT
admet-704	113	12	it	it	PRON
admet-704	113	13	is	be	AUX
admet-704	113	14	asami	asami	PROPN
admet-704	113	15	ono	ono	PROPN
admet-704	113	16	et	et	PROPN
admet-704	113	17	.	.	PUNCT
admet-704	114	1	al	al	PROPN
admet-704	114	2	admet	admet	PROPN
admet-704	114	3	&	&	CCONJ
admet-704	114	4	dmpk	dmpk	PROPN
admet-704	114	5	7(3	7(3	NUM
admet-704	114	6	)	)	PUNCT
admet-704	114	7	(	(	PUNCT
admet-704	114	8	2019	2019	NUM
admet-704	114	9	)	)	PUNCT
admet-704	114	10	183	183	NUM
admet-704	114	11	-	-	SYM
admet-704	114	12	195	195	NUM
admet-704	114	13	188	188	NUM
admet-704	114	14	recommended	recommend	VERB
admet-704	114	15	to	to	PART
admet-704	114	16	pre	pre	VERB
admet-704	114	17	-	-	ADJ
admet-704	114	18	warm	warm	ADJ
admet-704	114	19	filters	filter	NOUN
admet-704	114	20	and	and	CCONJ
admet-704	114	21	syringes	syrinx	NOUN
admet-704	114	22	before	before	ADP
admet-704	114	23	filtration	filtration	NOUN
admet-704	114	24	[	[	X
admet-704	114	25	49	49	NUM
admet-704	114	26	]	]	PUNCT
admet-704	114	27	.	.	PUNCT
admet-704	115	1	light	light	ADJ
admet-704	115	2	shielding	shielding	NOUN
admet-704	115	3	.	.	PUNCT
admet-704	116	1	it	it	PRON
admet-704	116	2	is	be	AUX
admet-704	116	3	recommended	recommend	VERB
admet-704	116	4	to	to	PART
admet-704	116	5	shade	shade	VERB
admet-704	116	6	the	the	DET
admet-704	116	7	sample	sample	NOUN
admet-704	116	8	during	during	ADP
admet-704	116	9	the	the	DET
admet-704	116	10	solubility	solubility	NOUN
admet-704	116	11	measurements	measurement	NOUN
admet-704	116	12	.	.	PUNCT
admet-704	117	1	sedimentation	sedimentation	NOUN
admet-704	117	2	after	after	ADP
admet-704	117	3	agitation	agitation	NOUN
admet-704	117	4	.	.	PUNCT
admet-704	118	1	it	it	PRON
admet-704	118	2	is	be	AUX
admet-704	118	3	recommended	recommend	VERB
admet-704	118	4	to	to	PART
admet-704	118	5	settle	settle	VERB
admet-704	118	6	the	the	DET
admet-704	118	7	residual	residual	ADJ
admet-704	118	8	solids	solid	NOUN
admet-704	118	9	after	after	ADP
admet-704	118	10	agitation	agitation	NOUN
admet-704	118	11	to	to	PART
admet-704	118	12	facilitate	facilitate	VERB
admet-704	118	13	filtration	filtration	NOUN
admet-704	118	14	.	.	PUNCT
admet-704	119	1	sedimentation	sedimentation	NOUN
admet-704	119	2	can	can	AUX
admet-704	119	3	also	also	ADV
admet-704	119	4	prevent	prevent	VERB
admet-704	119	5	the	the	DET
admet-704	119	6	formation	formation	NOUN
admet-704	119	7	of	of	ADP
admet-704	119	8	a	a	DET
admet-704	119	9	supersaturated	supersaturated	ADJ
admet-704	119	10	solution	solution	NOUN
admet-704	119	11	by	by	ADP
admet-704	119	12	intensive	intensive	ADJ
admet-704	119	13	stirring	stirring	NOUN
admet-704	119	14	[	[	X
admet-704	119	15	28	28	NUM
admet-704	119	16	,	,	PUNCT
admet-704	119	17	43	43	NUM
admet-704	119	18	]	]	PUNCT
admet-704	119	19	.	.	PUNCT
admet-704	120	1	the	the	DET
admet-704	120	2	abovementioned	abovementioned	ADJ
admet-704	120	3	mandatory	mandatory	ADJ
admet-704	120	4	and	and	CCONJ
admet-704	120	5	recommended	recommend	VERB
admet-704	120	6	items	item	NOUN
admet-704	120	7	were	be	AUX
admet-704	120	8	embodied	embody	VERB
admet-704	120	9	as	as	ADP
admet-704	120	10	a	a	DET
admet-704	120	11	hp	hp	NOUN
admet-704	120	12	,	,	PUNCT
admet-704	120	13	considering	consider	VERB
admet-704	120	14	practicability	practicability	NOUN
admet-704	120	15	at	at	ADP
admet-704	120	16	each	each	DET
admet-704	120	17	company	company	NOUN
admet-704	120	18	(	(	PUNCT
admet-704	120	19	see	see	VERB
admet-704	120	20	experimental	experimental	ADJ
admet-704	120	21	section	section	NOUN
admet-704	120	22	)	)	PUNCT
admet-704	120	23	.	.	PUNCT
admet-704	121	1	some	some	DET
admet-704	121	2	flexibility	flexibility	NOUN
admet-704	121	3	was	be	AUX
admet-704	121	4	left	leave	VERB
admet-704	121	5	in	in	ADP
admet-704	121	6	the	the	DET
admet-704	121	7	hp	hp	NOUN
admet-704	121	8	so	so	SCONJ
admet-704	121	9	that	that	SCONJ
admet-704	121	10	it	it	PRON
admet-704	121	11	could	could	AUX
admet-704	121	12	be	be	AUX
admet-704	121	13	practically	practically	ADV
admet-704	121	14	applied	apply	VERB
admet-704	121	15	to	to	ADP
admet-704	121	16	each	each	DET
admet-704	121	17	company	company	NOUN
admet-704	121	18	.	.	PUNCT
admet-704	122	1	in	in	ADP
admet-704	122	2	the	the	DET
admet-704	122	3	previous	previous	ADJ
admet-704	122	4	consensus	consensus	NOUN
admet-704	122	5	recommendation	recommendation	NOUN
admet-704	122	6	paper	paper	NOUN
admet-704	122	7	,	,	PUNCT
admet-704	122	8	sedimentation	sedimentation	NOUN
admet-704	122	9	was	be	AUX
admet-704	122	10	recommended	recommend	VERB
admet-704	122	11	as	as	ADP
admet-704	122	12	the	the	DET
admet-704	122	13	first	first	ADJ
admet-704	122	14	choice	choice	NOUN
admet-704	122	15	to	to	ADP
admet-704	122	16	separate	separate	ADJ
admet-704	122	17	solids	solid	NOUN
admet-704	122	18	from	from	ADP
admet-704	122	19	solution	solution	NOUN
admet-704	122	20	[	[	X
admet-704	122	21	28	28	NUM
admet-704	122	22	]	]	PUNCT
admet-704	122	23	.	.	PUNCT
admet-704	123	1	however	however	ADV
admet-704	123	2	,	,	PUNCT
admet-704	123	3	direct	direct	ADJ
admet-704	123	4	sampling	sampling	NOUN
admet-704	123	5	from	from	ADP
admet-704	123	6	the	the	DET
admet-704	123	7	supernatant	supernatant	NOUN
admet-704	123	8	requires	require	VERB
admet-704	123	9	some	some	DET
admet-704	123	10	technical	technical	ADJ
admet-704	123	11	skills	skill	NOUN
admet-704	123	12	,	,	PUNCT
admet-704	123	13	especially	especially	ADV
admet-704	123	14	when	when	SCONJ
admet-704	123	15	using	use	VERB
admet-704	123	16	small	small	ADJ
admet-704	123	17	vials	vial	NOUN
admet-704	123	18	or	or	CCONJ
admet-704	123	19	microtubes	microtube	NOUN
admet-704	123	20	.	.	PUNCT
admet-704	124	1	fine	fine	ADJ
admet-704	124	2	powders	powder	NOUN
admet-704	124	3	may	may	AUX
admet-704	124	4	be	be	AUX
admet-704	124	5	re	re	VERB
admet-704	124	6	-	-	VERB
admet-704	124	7	suspended	suspend	VERB
admet-704	124	8	even	even	ADV
admet-704	124	9	by	by	ADP
admet-704	124	10	slight	slight	ADJ
admet-704	124	11	stimulation	stimulation	NOUN
admet-704	124	12	.	.	PUNCT
admet-704	125	1	therefore	therefore	ADV
admet-704	125	2	,	,	PUNCT
admet-704	125	3	we	we	PRON
admet-704	125	4	used	use	VERB
admet-704	125	5	filtration	filtration	NOUN
admet-704	125	6	in	in	ADP
admet-704	125	7	the	the	DET
admet-704	125	8	harmonized	harmonized	ADJ
admet-704	125	9	protocol	protocol	NOUN
admet-704	125	10	.	.	PUNCT
admet-704	126	1	equilibrium	equilibrium	NOUN
admet-704	126	2	solubility	solubility	NOUN
admet-704	126	3	measured	measure	VERB
admet-704	126	4	by	by	ADP
admet-704	126	5	nonhp	nonhp	NOUN
admet-704	126	6	and	and	CCONJ
admet-704	126	7	hp	hp	VERB
admet-704	126	8	eight	eight	NUM
admet-704	126	9	companies	company	NOUN
admet-704	126	10	participated	participate	VERB
admet-704	126	11	in	in	ADP
admet-704	126	12	this	this	DET
admet-704	126	13	study	study	NOUN
admet-704	126	14	(	(	PUNCT
admet-704	126	15	a	a	DET
admet-704	126	16	to	to	PART
admet-704	126	17	h	h	NUM
admet-704	126	18	)	)	PUNCT
admet-704	126	19	.	.	PUNCT
admet-704	127	1	the	the	DET
admet-704	127	2	equilibrium	equilibrium	NOUN
admet-704	127	3	solubility	solubility	NOUN
admet-704	127	4	of	of	ADP
admet-704	127	5	four	four	NUM
admet-704	127	6	model	model	NOUN
admet-704	127	7	drugs	drug	NOUN
admet-704	127	8	in	in	ADP
admet-704	127	9	the	the	DET
admet-704	127	10	jp	jp	NOUN
admet-704	127	11	2nd	2nd	ADJ
admet-704	127	12	fluid	fluid	NOUN
admet-704	127	13	(	(	PUNCT
admet-704	127	14	ph	ph	NOUN
admet-704	127	15	6.8	6.8	NUM
admet-704	127	16	)	)	PUNCT
admet-704	127	17	was	be	AUX
admet-704	127	18	measured	measure	VERB
admet-704	127	19	by	by	ADP
admet-704	127	20	the	the	DET
admet-704	127	21	nonhp	nonhp	NOUN
admet-704	127	22	and	and	CCONJ
admet-704	127	23	hp	hp	PROPN
admet-704	127	24	(	(	PUNCT
admet-704	127	25	tables	table	NOUN
admet-704	127	26	3	3	NUM
admet-704	127	27	and	and	CCONJ
admet-704	127	28	4	4	NUM
admet-704	127	29	,	,	PUNCT
admet-704	127	30	respectively	respectively	ADV
admet-704	127	31	)	)	PUNCT
admet-704	127	32	.	.	PUNCT
admet-704	128	1	the	the	DET
admet-704	128	2	comparisons	comparison	NOUN
admet-704	128	3	of	of	ADP
admet-704	128	4	the	the	DET
admet-704	128	5	solubility	solubility	NOUN
admet-704	128	6	values	value	NOUN
admet-704	128	7	between	between	ADP
admet-704	128	8	laboratories	laboratory	NOUN
admet-704	128	9	are	be	AUX
admet-704	128	10	shown	show	VERB
admet-704	128	11	in	in	ADP
admet-704	128	12	figure	figure	NOUN
admet-704	128	13	3	3	NUM
admet-704	128	14	.	.	PUNCT
admet-704	128	15	table	table	NOUN
admet-704	128	16	3	3	NUM
admet-704	128	17	.	.	PUNCT
admet-704	128	18	equilibrium	equilibrium	NOUN
admet-704	128	19	solubility	solubility	NOUN
admet-704	128	20	of	of	ADP
admet-704	128	21	model	model	NOUN
admet-704	128	22	drugs	drug	NOUN
admet-704	128	23	in	in	ADP
admet-704	128	24	the	the	DET
admet-704	128	25	jp	jp	NOUN
admet-704	129	1	2	2	NUM
admet-704	129	2	nd	nd	NOUN
admet-704	129	3	fluid	fluid	NOUN
admet-704	129	4	(	(	PUNCT
admet-704	129	5	ph	ph	NOUN
admet-704	129	6	6.8	6.8	NUM
admet-704	129	7	)	)	PUNCT
admet-704	129	8	obtained	obtain	VERB
admet-704	129	9	by	by	ADP
admet-704	129	10	the	the	DET
admet-704	129	11	proprietary	proprietary	ADJ
admet-704	129	12	protocols	protocol	NOUN
admet-704	129	13	of	of	ADP
admet-704	129	14	each	each	DET
admet-704	129	15	company	company	NOUN
admet-704	129	16	before	before	ADP
admet-704	129	17	harmonization	harmonization	NOUN
admet-704	129	18	.	.	PUNCT
admet-704	130	1	compound	compound	NOUN
admet-704	130	2	solubility	solubility	NOUN
admet-704	130	3	(	(	PUNCT
admet-704	130	4	sd	sd	NOUN
admet-704	130	5	)	)	PUNCT
admet-704	130	6	(	(	PUNCT
admet-704	130	7	µg/	µg/	PROPN
admet-704	130	8	ml	ml	VERB
admet-704	130	9	)	)	PUNCT
admet-704	130	10	cv%	cv%	PROPN
admet-704	130	11	a	a	DET
admet-704	130	12	a	a	DET
admet-704	130	13	b	b	NOUN
admet-704	130	14	c	c	NOUN
admet-704	130	15	d	d	X
admet-704	130	16	e	e	X
admet-704	130	17	f	f	PROPN
admet-704	130	18	h	h	PROPN
admet-704	130	19	average	average	ADJ
admet-704	130	20	albendazole	albendazole	NOUN
admet-704	130	21	0.29	0.29	NUM
admet-704	130	22	(	(	PUNCT
admet-704	130	23	0.02	0.02	NUM
admet-704	130	24	)	)	PUNCT
admet-704	130	25	0.67	0.67	NUM
admet-704	130	26	(	(	PUNCT
admet-704	130	27	0.05	0.05	NUM
admet-704	130	28	)	)	PUNCT
admet-704	130	29	0.25	0.25	NUM
admet-704	130	30	(	(	PUNCT
admet-704	130	31	0.03	0.03	NUM
admet-704	130	32	)	)	PUNCT
admet-704	130	33	0.86	0.86	NUM
admet-704	130	34	(	(	PUNCT
admet-704	130	35	0.02	0.02	NUM
admet-704	130	36	)	)	PUNCT
admet-704	130	37	3.74	3.74	NUM
admet-704	130	38	(	(	PUNCT
admet-704	130	39	1.44	1.44	NUM
admet-704	130	40	)	)	PUNCT
admet-704	130	41	1.10	1.10	NUM
admet-704	130	42	(	(	PUNCT
admet-704	130	43	0.01	0.01	NUM
admet-704	130	44	)	)	PUNCT
admet-704	130	45	0.25	0.25	NUM
admet-704	130	46	(	(	PUNCT
admet-704	130	47	0.03	0.03	NUM
admet-704	130	48	)	)	PUNCT
admet-704	130	49	1.02	1.02	NUM
admet-704	130	50	(	(	PUNCT
admet-704	130	51	1.15	1.15	NUM
admet-704	130	52	)	)	PUNCT
admet-704	130	53	113	113	NUM
admet-704	130	54	griseofulvin	griseofulvin	NOUN
admet-704	130	55	5.7	5.7	NUM
admet-704	130	56	(	(	PUNCT
admet-704	130	57	0.3	0.3	NUM
admet-704	130	58	)	)	PUNCT
admet-704	130	59	12.0	12.0	NUM
admet-704	130	60	(	(	PUNCT
admet-704	130	61	0.2	0.2	NUM
admet-704	130	62	)	)	PUNCT
admet-704	130	63	11.0	11.0	NUM
admet-704	130	64	(	(	PUNCT
admet-704	130	65	0.1	0.1	NUM
admet-704	130	66	)	)	PUNCT
admet-704	130	67	11.7	11.7	NUM
admet-704	130	68	(	(	PUNCT
admet-704	130	69	0.1	0.1	NUM
admet-704	130	70	)	)	PUNCT
admet-704	130	71	12.2	12.2	NUM
admet-704	130	72	(	(	PUNCT
admet-704	130	73	0.2	0.2	NUM
admet-704	130	74	)	)	PUNCT
admet-704	130	75	12.1	12.1	NUM
admet-704	130	76	(	(	PUNCT
admet-704	130	77	0.0	0.0	NUM
admet-704	130	78	)	)	PUNCT
admet-704	130	79	11.1	11.1	NUM
admet-704	130	80	(	(	PUNCT
admet-704	130	81	0.1	0.1	NUM
admet-704	130	82	)	)	PUNCT
admet-704	130	83	10.8	10.8	NUM
admet-704	130	84	(	(	PUNCT
admet-704	130	85	2.12	2.12	NUM
admet-704	130	86	)	)	PUNCT
admet-704	130	87	20	20	NUM
admet-704	130	88	dipyridamole	dipyridamole	NOUN
admet-704	130	89	1.24	1.24	NUM
admet-704	130	90	(	(	PUNCT
admet-704	130	91	0.11	0.11	NUM
admet-704	130	92	)	)	PUNCT
admet-704	130	93	4.08	4.08	NUM
admet-704	130	94	(	(	PUNCT
admet-704	130	95	0.29	0.29	NUM
admet-704	130	96	)	)	PUNCT
admet-704	130	97	0.66	0.66	NUM
admet-704	130	98	(	(	PUNCT
admet-704	130	99	0.02	0.02	NUM
admet-704	130	100	)	)	PUNCT
admet-704	130	101	4.63	4.63	NUM
admet-704	130	102	(	(	PUNCT
admet-704	130	103	0.02	0.02	NUM
admet-704	130	104	)	)	PUNCT
admet-704	130	105	7.69	7.69	NUM
admet-704	130	106	(	(	PUNCT
admet-704	130	107	2.88	2.88	NUM
admet-704	130	108	)	)	PUNCT
admet-704	130	109	5.22	5.22	NUM
admet-704	130	110	(	(	PUNCT
admet-704	130	111	0.14	0.14	NUM
admet-704	130	112	)	)	PUNCT
admet-704	130	113	0.66	0.66	NUM
admet-704	130	114	(	(	PUNCT
admet-704	130	115	0.02	0.02	NUM
admet-704	130	116	)	)	PUNCT
admet-704	130	117	3.45	3.45	NUM
admet-704	130	118	(	(	PUNCT
admet-704	130	119	2.49	2.49	NUM
admet-704	130	120	)	)	PUNCT
admet-704	130	121	72	72	NUM
admet-704	130	122	glibenclamide	glibenclamide	NOUN
admet-704	130	123	1.1	1.1	NUM
admet-704	130	124	(	(	PUNCT
admet-704	130	125	0.0	0.0	NUM
admet-704	130	126	)	)	PUNCT
admet-704	130	127	3.4	3.4	NUM
admet-704	130	128	(	(	PUNCT
admet-704	130	129	0.1	0.1	NUM
admet-704	130	130	)	)	PUNCT
admet-704	130	131	3.0	3.0	NUM
admet-704	130	132	(	(	PUNCT
admet-704	130	133	0.0	0.0	NUM
admet-704	130	134	)	)	PUNCT
admet-704	130	135	4.6	4.6	NUM
admet-704	130	136	(	(	PUNCT
admet-704	130	137	0.0	0.0	NUM
admet-704	130	138	)	)	PUNCT
admet-704	130	139	5.4	5.4	NUM
admet-704	130	140	(	(	PUNCT
admet-704	130	141	0.4	0.4	NUM
admet-704	130	142	)	)	PUNCT
admet-704	130	143	3.2	3.2	NUM
admet-704	130	144	(	(	PUNCT
admet-704	130	145	0.2	0.2	NUM
admet-704	130	146	)	)	PUNCT
admet-704	130	147	3.0	3.0	NUM
admet-704	130	148	(	(	PUNCT
admet-704	130	149	0.0	0.0	NUM
admet-704	130	150	)	)	PUNCT
admet-704	130	151	3.4	3.4	NUM
admet-704	130	152	(	(	PUNCT
admet-704	130	153	1.3	1.3	NUM
admet-704	130	154	)	)	PUNCT
admet-704	130	155	38	38	NUM
admet-704	130	156	a	a	DET
admet-704	130	157	coefficient	coefficient	NOUN
admet-704	130	158	of	of	ADP
admet-704	130	159	variation	variation	NOUN
admet-704	130	160	of	of	ADP
admet-704	130	161	solubility	solubility	NOUN
admet-704	130	162	values	value	NOUN
admet-704	130	163	obtained	obtain	VERB
admet-704	130	164	from	from	ADP
admet-704	130	165	7	7	NUM
admet-704	130	166	companies	company	NOUN
admet-704	130	167	.	.	PUNCT
admet-704	131	1	table	table	NOUN
admet-704	131	2	4	4	NUM
admet-704	131	3	.	.	PUNCT
admet-704	131	4	equilibrium	equilibrium	NOUN
admet-704	131	5	solubility	solubility	NOUN
admet-704	131	6	of	of	ADP
admet-704	131	7	model	model	NOUN
admet-704	131	8	drugs	drug	NOUN
admet-704	131	9	in	in	ADP
admet-704	131	10	the	the	DET
admet-704	131	11	jp	jp	NOUN
admet-704	131	12	2	2	NUM
admet-704	131	13	nd	nd	NOUN
admet-704	131	14	fluid	fluid	NOUN
admet-704	131	15	(	(	PUNCT
admet-704	131	16	ph	ph	NOUN
admet-704	131	17	6.8	6.8	NUM
admet-704	131	18	)	)	PUNCT
admet-704	131	19	obtained	obtain	VERB
admet-704	131	20	by	by	ADP
admet-704	131	21	the	the	DET
admet-704	131	22	harmonized	harmonized	ADJ
admet-704	131	23	protocol	protocol	NOUN
admet-704	131	24	.	.	PUNCT
admet-704	132	1	compound	compound	NOUN
admet-704	132	2	solubility	solubility	NOUN
admet-704	132	3	(	(	PUNCT
admet-704	132	4	sd	sd	NOUN
admet-704	132	5	)	)	PUNCT
admet-704	132	6	(	(	PUNCT
admet-704	132	7	µg/	µg/	PROPN
admet-704	132	8	ml	ml	VERB
admet-704	132	9	)	)	PUNCT
admet-704	132	10	cv%	cv%	PROPN
admet-704	132	11	a	a	DET
admet-704	132	12	a	a	DET
admet-704	132	13	b	b	NOUN
admet-704	132	14	c	c	NOUN
admet-704	132	15	d	d	PROPN
admet-704	132	16	e	e	X
admet-704	132	17	f	f	PROPN
admet-704	132	18	g	g	PROPN
admet-704	132	19	h	h	PROPN
admet-704	132	20	average	average	ADJ
admet-704	132	21	albendazole	albendazole	NOUN
admet-704	132	22	1.11	1.11	NUM
admet-704	132	23	(	(	PUNCT
admet-704	132	24	0.14	0.14	NUM
admet-704	132	25	)	)	PUNCT
admet-704	132	26	0.73	0.73	NUM
admet-704	132	27	(	(	PUNCT
admet-704	132	28	0.08	0.08	NUM
admet-704	132	29	)	)	PUNCT
admet-704	132	30	0.71	0.71	NUM
admet-704	132	31	(	(	PUNCT
admet-704	132	32	0.03	0.03	NUM
admet-704	132	33	)	)	PUNCT
admet-704	132	34	0.86	0.86	NUM
admet-704	132	35	(	(	PUNCT
admet-704	132	36	0.02	0.02	NUM
admet-704	132	37	)	)	PUNCT
admet-704	132	38	0.79	0.79	NUM
admet-704	132	39	(	(	PUNCT
admet-704	132	40	0.02	0.02	NUM
admet-704	132	41	)	)	PUNCT
admet-704	132	42	0.96	0.96	NUM
admet-704	132	43	(	(	PUNCT
admet-704	132	44	0.04	0.04	NUM
admet-704	132	45	)	)	PUNCT
admet-704	132	46	1.01	1.01	NUM
admet-704	132	47	(	(	PUNCT
admet-704	132	48	0.02	0.02	NUM
admet-704	132	49	)	)	PUNCT
admet-704	132	50	0.70	0.70	NUM
admet-704	132	51	(	(	PUNCT
admet-704	132	52	0.03	0.03	NUM
admet-704	132	53	)	)	PUNCT
admet-704	132	54	0.86	0.86	NUM
admet-704	132	55	(	(	PUNCT
admet-704	132	56	0.14	0.14	NUM
admet-704	132	57	)	)	PUNCT
admet-704	132	58	17	17	NUM
admet-704	132	59	griseofulvin	griseofulvin	NOUN
admet-704	132	60	12.0	12.0	NUM
admet-704	132	61	(	(	PUNCT
admet-704	132	62	0.5	0.5	NUM
admet-704	132	63	)	)	PUNCT
admet-704	132	64	10.5	10.5	NUM
admet-704	132	65	(	(	PUNCT
admet-704	132	66	0.1	0.1	NUM
admet-704	132	67	)	)	PUNCT
admet-704	132	68	11.4	11.4	NUM
admet-704	132	69	(	(	PUNCT
admet-704	132	70	0.2	0.2	NUM
admet-704	132	71	)	)	PUNCT
admet-704	132	72	12.3	12.3	NUM
admet-704	132	73	(	(	PUNCT
admet-704	132	74	0.1	0.1	NUM
admet-704	132	75	)	)	PUNCT
admet-704	132	76	11.7	11.7	NUM
admet-704	132	77	(	(	PUNCT
admet-704	132	78	0.1	0.1	NUM
admet-704	132	79	)	)	PUNCT
admet-704	132	80	12.7	12.7	NUM
admet-704	132	81	(	(	PUNCT
admet-704	132	82	0.3	0.3	NUM
admet-704	132	83	)	)	PUNCT
admet-704	132	84	13.0	13.0	NUM
admet-704	132	85	(	(	PUNCT
admet-704	132	86	0.1	0.1	NUM
admet-704	132	87	)	)	PUNCT
admet-704	132	88	11.5	11.5	NUM
admet-704	132	89	(	(	PUNCT
admet-704	132	90	0.2	0.2	NUM
admet-704	132	91	)	)	PUNCT
admet-704	132	92	11.9	11.9	NUM
admet-704	132	93	(	(	PUNCT
admet-704	132	94	0.75	0.75	NUM
admet-704	132	95	)	)	PUNCT
admet-704	132	96	6	6	NUM
admet-704	132	97	dipyridamole	dipyridamole	NOUN
admet-704	132	98	5.15	5.15	NUM
admet-704	132	99	(	(	PUNCT
admet-704	132	100	0.02	0.02	NUM
admet-704	132	101	)	)	PUNCT
admet-704	132	102	3.27	3.27	NUM
admet-704	132	103	(	(	PUNCT
admet-704	132	104	0.06	0.06	NUM
admet-704	132	105	)	)	PUNCT
admet-704	132	106	3.69	3.69	NUM
admet-704	132	107	(	(	PUNCT
admet-704	132	108	0.37	0.37	NUM
admet-704	132	109	)	)	PUNCT
admet-704	132	110	5.65	5.65	NUM
admet-704	132	111	(	(	PUNCT
admet-704	132	112	0.09	0.09	NUM
admet-704	132	113	)	)	PUNCT
admet-704	132	114	5.67	5.67	NUM
admet-704	132	115	(	(	PUNCT
admet-704	132	116	0.50	0.50	NUM
admet-704	132	117	)	)	PUNCT
admet-704	132	118	5.07	5.07	NUM
admet-704	132	119	(	(	PUNCT
admet-704	132	120	0.09	0.09	NUM
admet-704	132	121	)	)	PUNCT
admet-704	132	122	5.62	5.62	NUM
admet-704	132	123	(	(	PUNCT
admet-704	132	124	0.25	0.25	NUM
admet-704	132	125	)	)	PUNCT
admet-704	132	126	3.70	3.70	NUM
admet-704	132	127	(	(	PUNCT
admet-704	132	128	0.37	0.37	NUM
admet-704	132	129	)	)	PUNCT
admet-704	132	130	4.73	4.73	NUM
admet-704	132	131	(	(	PUNCT
admet-704	132	132	0.94	0.94	NUM
admet-704	132	133	)	)	PUNCT
admet-704	132	134	20	20	NUM
admet-704	132	135	glibenclamide	glibenclamide	ADP
admet-704	132	136	5.2	5.2	NUM
admet-704	132	137	(	(	PUNCT
admet-704	132	138	0.4	0.4	NUM
admet-704	132	139	)	)	PUNCT
admet-704	132	140	3.7	3.7	NUM
admet-704	132	141	(	(	PUNCT
admet-704	132	142	0.2	0.2	NUM
admet-704	132	143	)	)	PUNCT
admet-704	132	144	4.8	4.8	NUM
admet-704	132	145	(	(	PUNCT
admet-704	132	146	0.0	0.0	NUM
admet-704	132	147	)	)	PUNCT
admet-704	132	148	4.4	4.4	NUM
admet-704	132	149	(	(	PUNCT
admet-704	132	150	0.5	0.5	NUM
admet-704	132	151	)	)	PUNCT
admet-704	132	152	5.2	5.2	NUM
admet-704	132	153	(	(	PUNCT
admet-704	132	154	0.3	0.3	NUM
admet-704	132	155	)	)	PUNCT
admet-704	132	156	5.7	5.7	NUM
admet-704	132	157	(	(	PUNCT
admet-704	132	158	0.2	0.2	NUM
admet-704	132	159	)	)	PUNCT
admet-704	132	160	5.6	5.6	NUM
admet-704	132	161	(	(	PUNCT
admet-704	132	162	0.1	0.1	NUM
admet-704	132	163	)	)	PUNCT
admet-704	132	164	4.8	4.8	NUM
admet-704	132	165	(	(	PUNCT
admet-704	132	166	0.0	0.0	NUM
admet-704	132	167	)	)	PUNCT
admet-704	132	168	4.9	4.9	NUM
admet-704	132	169	(	(	PUNCT
admet-704	132	170	0.6	0.6	NUM
admet-704	132	171	)	)	PUNCT
admet-704	132	172	13	13	NUM
admet-704	132	173	a	a	DET
admet-704	132	174	coefficient	coefficient	NOUN
admet-704	132	175	of	of	ADP
admet-704	132	176	variation	variation	NOUN
admet-704	132	177	of	of	ADP
admet-704	132	178	solubility	solubility	NOUN
admet-704	132	179	values	value	NOUN
admet-704	132	180	obtained	obtain	VERB
admet-704	132	181	from	from	ADP
admet-704	132	182	8	8	NUM
admet-704	132	183	companies	company	NOUN
admet-704	132	184	.	.	PUNCT
admet-704	133	1	the	the	DET
admet-704	133	2	solubility	solubility	NOUN
admet-704	133	3	values	value	NOUN
admet-704	133	4	measured	measure	VERB
admet-704	133	5	by	by	ADP
admet-704	133	6	the	the	DET
admet-704	133	7	nonhps	nonhps	NOUN
admet-704	133	8	showed	show	VERB
admet-704	133	9	marked	mark	VERB
admet-704	133	10	inter	inter	ADJ
admet-704	133	11	-	-	ADJ
admet-704	133	12	laboratory	laboratory	ADJ
admet-704	133	13	variance	variance	NOUN
admet-704	133	14	for	for	ADP
admet-704	133	15	albendazole	albendazole	NOUN
admet-704	133	16	,	,	PUNCT
admet-704	133	17	dipyridamole	dipyridamole	NOUN
admet-704	133	18	,	,	PUNCT
admet-704	133	19	and	and	CCONJ
admet-704	133	20	glibenclamide	glibenclamide	NOUN
admet-704	133	21	(	(	PUNCT
admet-704	133	22	cv	cv	PROPN
admet-704	133	23	=	=	SYM
admet-704	133	24	113	113	NUM
admet-704	133	25	,	,	PUNCT
admet-704	133	26	72	72	NUM
admet-704	133	27	,	,	PUNCT
admet-704	133	28	and	and	CCONJ
admet-704	133	29	38	38	NUM
admet-704	133	30	%	%	NOUN
admet-704	133	31	,	,	PUNCT
admet-704	133	32	respectively	respectively	ADV
admet-704	133	33	)	)	PUNCT
admet-704	133	34	.	.	PUNCT
admet-704	134	1	for	for	ADP
admet-704	134	2	griseofulvin	griseofulvin	NOUN
admet-704	134	3	,	,	PUNCT
admet-704	134	4	the	the	DET
admet-704	134	5	admet	admet	PROPN
admet-704	134	6	&	&	CCONJ
admet-704	134	7	dmpk	dmpk	PROPN
admet-704	134	8	7(3	7(3	NUM
admet-704	134	9	)	)	PUNCT
admet-704	134	10	(	(	PUNCT
admet-704	134	11	2019	2019	NUM
admet-704	134	12	)	)	PUNCT
admet-704	134	13	183	183	NUM
admet-704	134	14	-	-	SYM
admet-704	134	15	195	195	NUM
admet-704	134	16	harmonizing	harmonize	VERB
admet-704	134	17	solubility	solubility	NOUN
admet-704	134	18	measurement	measurement	NOUN
admet-704	134	19	to	to	PART
admet-704	134	20	lower	lower	VERB
admet-704	134	21	inter	inter	ADJ
admet-704	134	22	-	-	ADJ
admet-704	134	23	laboratory	laboratory	ADJ
admet-704	134	24	variance	variance	NOUN
admet-704	134	25	doi	doi	NOUN
admet-704	134	26	:	:	PUNCT
admet-704	134	27	10.5599	10.5599	NUM
admet-704	134	28	/	/	SYM
admet-704	134	29	admet.704	admet.704	ADJ
admet-704	134	30	189	189	NUM
admet-704	134	31	inter	inter	ADJ
admet-704	134	32	-	-	ADJ
admet-704	134	33	laboratory	laboratory	ADJ
admet-704	134	34	variance	variance	NOUN
admet-704	134	35	was	be	AUX
admet-704	134	36	smaller	small	ADJ
admet-704	134	37	(	(	PUNCT
admet-704	134	38	cv	cv	PROPN
admet-704	134	39	=	=	SYM
admet-704	134	40	20	20	NUM
admet-704	134	41	%	%	NOUN
admet-704	134	42	)	)	PUNCT
admet-704	134	43	.	.	PUNCT
admet-704	135	1	the	the	DET
admet-704	135	2	solubility	solubility	NOUN
admet-704	135	3	of	of	ADP
admet-704	135	4	griseofulvin	griseofulvin	NOUN
admet-704	135	5	would	would	AUX
admet-704	135	6	be	be	AUX
admet-704	135	7	less	less	ADV
admet-704	135	8	susceptible	susceptible	ADJ
admet-704	135	9	to	to	ADP
admet-704	135	10	adsorption	adsorption	NOUN
admet-704	135	11	to	to	ADP
admet-704	135	12	a	a	DET
admet-704	135	13	filter	filter	NOUN
admet-704	135	14	and	and	CCONJ
admet-704	135	15	plastic	plastic	NOUN
admet-704	135	16	materials	material	NOUN
admet-704	135	17	because	because	SCONJ
admet-704	135	18	its	its	PRON
admet-704	135	19	lipophilicity	lipophilicity	NOUN
admet-704	135	20	is	be	AUX
admet-704	135	21	lower	low	ADJ
admet-704	135	22	than	than	ADP
admet-704	135	23	the	the	DET
admet-704	135	24	other	other	ADJ
admet-704	135	25	model	model	NOUN
admet-704	135	26	drugs	drug	NOUN
admet-704	135	27	.	.	PUNCT
admet-704	136	1	the	the	DET
admet-704	136	2	solubility	solubility	NOUN
admet-704	136	3	values	value	NOUN
admet-704	136	4	measured	measure	VERB
admet-704	136	5	by	by	ADP
admet-704	136	6	a	a	DET
admet-704	136	7	,	,	PUNCT
admet-704	136	8	c	c	NOUN
admet-704	136	9	and	and	CCONJ
admet-704	136	10	h	h	NOUN
admet-704	136	11	were	be	AUX
admet-704	136	12	lower	low	ADJ
admet-704	136	13	than	than	ADP
admet-704	136	14	the	the	DET
admet-704	136	15	others	other	NOUN
admet-704	136	16	probably	probably	ADV
admet-704	136	17	due	due	ADJ
admet-704	136	18	to	to	ADP
admet-704	136	19	adsorption	adsorption	NOUN
admet-704	136	20	to	to	ADP
admet-704	136	21	filters	filter	NOUN
admet-704	136	22	and	and	CCONJ
admet-704	136	23	tips	tip	NOUN
admet-704	136	24	.	.	PUNCT
admet-704	137	1	on	on	ADP
admet-704	137	2	the	the	DET
admet-704	137	3	other	other	ADJ
admet-704	137	4	hand	hand	NOUN
admet-704	137	5	,	,	PUNCT
admet-704	137	6	the	the	DET
admet-704	137	7	solubility	solubility	NOUN
admet-704	137	8	measured	measure	VERB
admet-704	137	9	by	by	ADP
admet-704	137	10	e	e	PROPN
admet-704	137	11	was	be	AUX
admet-704	137	12	higher	high	ADJ
admet-704	137	13	than	than	ADP
admet-704	137	14	the	the	DET
admet-704	137	15	others	other	NOUN
admet-704	137	16	probably	probably	ADV
admet-704	137	17	because	because	SCONJ
admet-704	137	18	centrifugation	centrifugation	NOUN
admet-704	137	19	was	be	AUX
admet-704	137	20	used	use	VERB
admet-704	137	21	to	to	PART
admet-704	137	22	separate	separate	ADJ
admet-704	137	23	solids	solid	NOUN
admet-704	137	24	from	from	ADP
admet-704	137	25	a	a	DET
admet-704	137	26	solution	solution	NOUN
admet-704	137	27	.	.	PUNCT
admet-704	138	1	figure	figure	NOUN
admet-704	138	2	3	3	NUM
admet-704	138	3	.	.	PUNCT
admet-704	139	1	solubility	solubility	NOUN
admet-704	139	2	of	of	ADP
admet-704	139	3	model	model	NOUN
admet-704	139	4	drugs	drug	NOUN
admet-704	139	5	measured	measure	VERB
admet-704	139	6	by	by	ADP
admet-704	139	7	the	the	DET
admet-704	139	8	non	non	ADJ
admet-704	139	9	-	-	ADJ
admet-704	139	10	harmonized	harmonized	ADJ
admet-704	139	11	proprietary	proprietary	ADJ
admet-704	139	12	protocols	protocol	NOUN
admet-704	139	13	(	(	PUNCT
admet-704	139	14	nonhps	nonhps	NOUN
admet-704	139	15	)	)	PUNCT
admet-704	139	16	and	and	CCONJ
admet-704	139	17	the	the	DET
admet-704	139	18	harmonized	harmonized	ADJ
admet-704	139	19	protocol	protocol	NOUN
admet-704	139	20	(	(	PUNCT
admet-704	139	21	hp	hp	PROPN
admet-704	139	22	)	)	PUNCT
admet-704	139	23	.	.	PUNCT
admet-704	140	1	in	in	ADP
admet-704	140	2	contrast	contrast	NOUN
admet-704	140	3	to	to	ADP
admet-704	140	4	the	the	DET
admet-704	140	5	nonhps	nonhps	NOUN
admet-704	140	6	,	,	PUNCT
admet-704	140	7	the	the	DET
admet-704	140	8	solubility	solubility	NOUN
admet-704	140	9	values	value	NOUN
admet-704	140	10	measured	measure	VERB
admet-704	140	11	by	by	ADP
admet-704	140	12	the	the	DET
admet-704	140	13	hp	hp	PROPN
admet-704	140	14	showed	show	VERB
admet-704	140	15	smaller	small	ADJ
admet-704	140	16	inter	inter	ADJ
admet-704	140	17	-	-	ADJ
admet-704	140	18	laboratory	laboratory	ADJ
admet-704	140	19	variance	variance	NOUN
admet-704	140	20	for	for	ADP
admet-704	140	21	all	all	DET
admet-704	140	22	model	model	NOUN
admet-704	140	23	drugs	drug	NOUN
admet-704	140	24	(	(	PUNCT
admet-704	140	25	cv	cv	X
admet-704	140	26	<	<	X
admet-704	140	27	20	20	NUM
admet-704	140	28	%	%	NOUN
admet-704	140	29	)	)	PUNCT
admet-704	140	30	.	.	PUNCT
admet-704	141	1	furthermore	furthermore	ADV
admet-704	141	2	,	,	PUNCT
admet-704	141	3	the	the	DET
admet-704	141	4	solubility	solubility	NOUN
admet-704	141	5	values	value	NOUN
admet-704	141	6	were	be	AUX
admet-704	141	7	in	in	ADP
admet-704	141	8	good	good	ADJ
admet-704	141	9	agreement	agreement	NOUN
admet-704	141	10	with	with	ADP
admet-704	141	11	the	the	DET
admet-704	141	12	literature	literature	NOUN
admet-704	141	13	values	value	NOUN
admet-704	141	14	(	(	PUNCT
admet-704	141	15	table	table	NOUN
admet-704	141	16	5	5	NUM
admet-704	141	17	)	)	PUNCT
admet-704	141	18	.	.	PUNCT
admet-704	142	1	the	the	DET
admet-704	142	2	final	final	ADJ
admet-704	142	3	ph	ph	ADJ
admet-704	142	4	values	value	NOUN
admet-704	142	5	were	be	AUX
admet-704	142	6	within	within	ADP
admet-704	142	7	±	±	NUM
admet-704	142	8	0.03	0.03	NUM
admet-704	142	9	of	of	ADP
admet-704	142	10	the	the	DET
admet-704	142	11	initial	initial	ADJ
admet-704	142	12	ph	ph	ADJ
admet-704	142	13	values	value	NOUN
admet-704	142	14	for	for	ADP
admet-704	142	15	all	all	DET
admet-704	142	16	model	model	NOUN
admet-704	142	17	drugs	drug	NOUN
admet-704	142	18	.	.	PUNCT
admet-704	143	1	the	the	DET
admet-704	143	2	solid	solid	ADJ
admet-704	143	3	phases	phase	NOUN
admet-704	143	4	of	of	ADP
admet-704	143	5	the	the	DET
admet-704	143	6	samples	sample	NOUN
admet-704	143	7	were	be	AUX
admet-704	143	8	evaluated	evaluate	VERB
admet-704	143	9	by	by	ADP
admet-704	143	10	pxrd	pxrd	NOUN
admet-704	143	11	before	before	ADP
admet-704	143	12	and	and	CCONJ
admet-704	143	13	after	after	ADP
admet-704	143	14	solubility	solubility	NOUN
admet-704	143	15	measurements	measurement	NOUN
admet-704	143	16	(	(	PUNCT
admet-704	143	17	by	by	ADP
admet-704	143	18	a	a	DET
admet-704	143	19	,	,	PUNCT
admet-704	143	20	b	b	NOUN
admet-704	143	21	,	,	PUNCT
admet-704	143	22	c	c	X
admet-704	143	23	,	,	PUNCT
admet-704	143	24	f	f	X
admet-704	143	25	,	,	PUNCT
admet-704	143	26	and	and	CCONJ
admet-704	143	27	h	h	NOUN
admet-704	143	28	)	)	PUNCT
admet-704	143	29	.	.	PUNCT
admet-704	144	1	as	as	SCONJ
admet-704	144	2	shown	show	VERB
admet-704	144	3	in	in	ADP
admet-704	144	4	figure	figure	NOUN
admet-704	144	5	4	4	NUM
admet-704	144	6	,	,	PUNCT
admet-704	144	7	no	no	DET
admet-704	144	8	solid	solid	ADJ
admet-704	144	9	form	form	NOUN
admet-704	144	10	transformation	transformation	NOUN
admet-704	144	11	occurred	occur	VERB
admet-704	144	12	during	during	ADP
admet-704	144	13	the	the	DET
admet-704	144	14	solubility	solubility	NOUN
admet-704	144	15	measurements	measurement	NOUN
admet-704	144	16	for	for	ADP
admet-704	144	17	all	all	DET
admet-704	144	18	model	model	NOUN
admet-704	144	19	drugs	drug	NOUN
admet-704	144	20	.	.	PUNCT
admet-704	145	1	the	the	DET
admet-704	145	2	concentration	concentration	NOUN
admet-704	145	3	-	-	PUNCT
admet-704	145	4	time	time	NOUN
admet-704	145	5	profiles	profile	NOUN
admet-704	145	6	were	be	AUX
admet-704	145	7	measured	measure	VERB
admet-704	145	8	to	to	PART
admet-704	145	9	confirm	confirm	VERB
admet-704	145	10	achieving	achieve	VERB
admet-704	145	11	equilibrium	equilibrium	NOUN
admet-704	145	12	by	by	ADP
admet-704	145	13	d	d	PROPN
admet-704	145	14	,	,	PUNCT
admet-704	145	15	e	e	NOUN
admet-704	145	16	,	,	PUNCT
admet-704	145	17	f	f	X
admet-704	145	18	,	,	PUNCT
admet-704	145	19	and	and	CCONJ
admet-704	145	20	g	g	PROPN
admet-704	145	21	(	(	PUNCT
admet-704	145	22	data	datum	NOUN
admet-704	145	23	not	not	PART
admet-704	145	24	shown	show	VERB
admet-704	145	25	)	)	PUNCT
admet-704	145	26	.	.	PUNCT
admet-704	146	1	the	the	DET
admet-704	146	2	solubility	solubility	NOUN
admet-704	146	3	measurements	measurement	NOUN
admet-704	146	4	were	be	AUX
admet-704	146	5	also	also	ADV
admet-704	146	6	performed	perform	VERB
admet-704	146	7	by	by	ADP
admet-704	146	8	the	the	DET
admet-704	146	9	µdiss	µdiss	NOUN
admet-704	146	10	profiler	profiler	NOUN
admet-704	146	11	.	.	PUNCT
admet-704	147	1	the	the	DET
admet-704	147	2	dissolution	dissolution	ADJ
admet-704	147	3	profiles	profile	NOUN
admet-704	147	4	of	of	ADP
admet-704	147	5	the	the	DET
admet-704	147	6	model	model	NOUN
admet-704	147	7	drugs	drug	NOUN
admet-704	147	8	were	be	AUX
admet-704	147	9	shown	show	VERB
admet-704	147	10	in	in	ADP
admet-704	147	11	figure	figure	NOUN
admet-704	147	12	5	5	NUM
admet-704	147	13	.	.	PUNCT
admet-704	148	1	the	the	DET
admet-704	148	2	solubility	solubility	NOUN
admet-704	148	3	values	value	NOUN
admet-704	148	4	of	of	ADP
admet-704	148	5	albendazole	albendazole	NOUN
admet-704	148	6	,	,	PUNCT
admet-704	148	7	griseofulvin	griseofulvin	NOUN
admet-704	148	8	,	,	PUNCT
admet-704	148	9	dipyridamole	dipyridamole	NOUN
admet-704	148	10	,	,	PUNCT
admet-704	148	11	and	and	CCONJ
admet-704	148	12	glibenclamide	glibenclamide	NOUN
admet-704	148	13	were	be	AUX
admet-704	148	14	0.69	0.69	NUM
admet-704	148	15	,	,	PUNCT
admet-704	148	16	13	13	NUM
admet-704	148	17	,	,	PUNCT
admet-704	148	18	5.2	5.2	NUM
admet-704	148	19	,	,	PUNCT
admet-704	148	20	5.5	5.5	NUM
admet-704	148	21	µg	µg	NOUN
admet-704	148	22	/	/	SYM
admet-704	148	23	ml	ml	NOUN
admet-704	148	24	,	,	PUNCT
admet-704	148	25	respectively	respectively	ADV
admet-704	148	26	.	.	PUNCT
admet-704	149	1	these	these	DET
admet-704	149	2	solubility	solubility	NOUN
admet-704	149	3	values	value	NOUN
admet-704	149	4	were	be	AUX
admet-704	149	5	similar	similar	ADJ
admet-704	149	6	to	to	ADP
admet-704	149	7	the	the	DET
admet-704	149	8	values	value	NOUN
admet-704	149	9	measured	measure	VERB
admet-704	149	10	by	by	ADP
admet-704	149	11	the	the	DET
admet-704	149	12	hp	hp	PROPN
admet-704	149	13	(	(	PUNCT
admet-704	149	14	table	table	NOUN
admet-704	149	15	5	5	NUM
admet-704	149	16	and	and	CCONJ
admet-704	149	17	figure	figure	VERB
admet-704	149	18	6	6	NUM
admet-704	149	19	)	)	PUNCT
admet-704	149	20	.	.	PUNCT
admet-704	150	1	asami	asami	PROPN
admet-704	150	2	ono	ono	PROPN
admet-704	150	3	et	et	PROPN
admet-704	150	4	.	.	PUNCT
admet-704	151	1	al	al	PROPN
admet-704	151	2	admet	admet	PROPN
admet-704	151	3	&	&	CCONJ
admet-704	151	4	dmpk	dmpk	PROPN
admet-704	151	5	7(3	7(3	NUM
admet-704	151	6	)	)	PUNCT
admet-704	151	7	(	(	PUNCT
admet-704	151	8	2019	2019	NUM
admet-704	151	9	)	)	PUNCT
admet-704	151	10	183	183	NUM
admet-704	151	11	-	-	SYM
admet-704	151	12	195	195	NUM
admet-704	151	13	190	190	NUM
admet-704	151	14	figure	figure	NOUN
admet-704	151	15	4	4	NUM
admet-704	151	16	.	.	PUNCT
admet-704	151	17	powder	powder	NOUN
admet-704	151	18	x	x	PROPN
admet-704	151	19	-	-	NOUN
admet-704	151	20	ray	ray	NOUN
admet-704	151	21	diffraction	diffraction	NOUN
admet-704	151	22	patterns	pattern	NOUN
admet-704	151	23	of	of	ADP
admet-704	151	24	samples	sample	NOUN
admet-704	151	25	obtained	obtain	VERB
admet-704	151	26	before	before	ADV
admet-704	151	27	(	(	PUNCT
admet-704	151	28	red	red	ADJ
admet-704	151	29	lines	line	NOUN
admet-704	151	30	)	)	PUNCT
admet-704	151	31	and	and	CCONJ
admet-704	151	32	after	after	ADP
admet-704	151	33	(	(	PUNCT
admet-704	151	34	blue	blue	ADJ
admet-704	151	35	lines	line	NOUN
admet-704	151	36	)	)	PUNCT
admet-704	151	37	solubility	solubility	NOUN
admet-704	151	38	assay	assay	PROPN
admet-704	151	39	(	(	PUNCT
admet-704	151	40	measured	measure	VERB
admet-704	151	41	by	by	ADP
admet-704	151	42	company	company	NOUN
admet-704	151	43	c	c	NOUN
admet-704	151	44	)	)	PUNCT
admet-704	151	45	(	(	PUNCT
admet-704	151	46	rigaku	rigaku	NOUN
admet-704	151	47	smartlab	smartlab	NOUN
admet-704	151	48	diffractometer	diffractometer	NOUN
admet-704	151	49	,	,	PUNCT
admet-704	151	50	rigaku	rigaku	NOUN
admet-704	151	51	,	,	PUNCT
admet-704	151	52	japan	japan	PROPN
admet-704	151	53	)	)	PUNCT
admet-704	151	54	.	.	PUNCT
admet-704	152	1	the	the	DET
admet-704	152	2	diffraction	diffraction	NOUN
admet-704	152	3	patterns	pattern	NOUN
admet-704	152	4	were	be	AUX
admet-704	152	5	collected	collect	VERB
admet-704	152	6	from	from	ADP
admet-704	152	7	5	5	NUM
admet-704	152	8	°	°	NOUN
admet-704	152	9	to	to	ADP
admet-704	152	10	40	40	NUM
admet-704	152	11	°	°	NOUN
admet-704	152	12	at	at	ADP
admet-704	152	13	a	a	DET
admet-704	152	14	scan	scan	ADJ
admet-704	152	15	rate	rate	NOUN
admet-704	152	16	of	of	ADP
admet-704	152	17	5	5	NUM
admet-704	152	18	°	°	NUM
admet-704	152	19	/min	/min	X
admet-704	152	20	(	(	PUNCT
admet-704	152	21	cu	cu	NOUN
admet-704	152	22	kα	kα	PROPN
admet-704	152	23	radiation	radiation	NOUN
admet-704	152	24	(	(	PUNCT
admet-704	152	25	40	40	NUM
admet-704	152	26	kv	kv	NOUN
admet-704	152	27	and	and	CCONJ
admet-704	152	28	30	30	NUM
admet-704	152	29	ma	ma	PROPN
admet-704	152	30	)	)	PUNCT
admet-704	152	31	,	,	PUNCT
admet-704	152	32	rigaku	rigaku	NOUN
admet-704	152	33	d	d	PROPN
admet-704	152	34	/	/	SYM
admet-704	152	35	tex	tex	PROPN
admet-704	152	36	ultra	ultra	ADJ
admet-704	152	37	-	-	ADJ
admet-704	152	38	highspeed	highspeed	ADJ
admet-704	152	39	position	position	NOUN
admet-704	152	40	-	-	PUNCT
admet-704	152	41	sensitive	sensitive	ADJ
admet-704	152	42	detector	detector	NOUN
admet-704	152	43	)	)	PUNCT
admet-704	152	44	.	.	PUNCT
admet-704	153	1	figure	figure	VERB
admet-704	153	2	5	5	NUM
admet-704	153	3	dissolution	dissolution	ADJ
admet-704	153	4	profiles	profile	NOUN
admet-704	153	5	of	of	ADP
admet-704	153	6	model	model	NOUN
admet-704	153	7	drugs	drug	NOUN
admet-704	153	8	by	by	ADP
admet-704	153	9	μdiss	μdiss	ADJ
admet-704	153	10	profiler	profiler	NOUN
admet-704	153	11	admet	admet	NOUN
admet-704	153	12	&	&	CCONJ
admet-704	153	13	dmpk	dmpk	PROPN
admet-704	153	14	7(3	7(3	NUM
admet-704	153	15	)	)	PUNCT
admet-704	153	16	(	(	PUNCT
admet-704	153	17	2019	2019	NUM
admet-704	153	18	)	)	PUNCT
admet-704	153	19	183	183	NUM
admet-704	153	20	-	-	SYM
admet-704	153	21	195	195	NUM
admet-704	153	22	harmonizing	harmonize	VERB
admet-704	153	23	solubility	solubility	NOUN
admet-704	153	24	measurement	measurement	NOUN
admet-704	153	25	to	to	PART
admet-704	153	26	lower	lower	VERB
admet-704	153	27	inter	inter	ADJ
admet-704	153	28	-	-	ADJ
admet-704	153	29	laboratory	laboratory	ADJ
admet-704	153	30	variance	variance	NOUN
admet-704	153	31	doi	doi	NOUN
admet-704	153	32	:	:	PUNCT
admet-704	153	33	10.5599	10.5599	NUM
admet-704	153	34	/	/	SYM
admet-704	153	35	admet.704	admet.704	ADJ
admet-704	153	36	191	191	NUM
admet-704	153	37	table	table	NOUN
admet-704	153	38	5	5	NUM
admet-704	153	39	.	.	PUNCT
admet-704	154	1	average	average	ADJ
admet-704	154	2	values	value	NOUN
admet-704	154	3	of	of	ADP
admet-704	154	4	equilibrium	equilibrium	NOUN
admet-704	154	5	solubility	solubility	NOUN
admet-704	154	6	of	of	ADP
admet-704	154	7	model	model	NOUN
admet-704	154	8	drugs	drug	NOUN
admet-704	154	9	obtained	obtain	VERB
admet-704	154	10	by	by	ADP
admet-704	154	11	different	different	ADJ
admet-704	154	12	methods	method	NOUN
admet-704	154	13	at	at	ADP
admet-704	154	14	ph	ph	PROPN
admet-704	154	15	6.8	6.8	NUM
admet-704	154	16	,	,	PUNCT
admet-704	154	17	37	37	NUM
admet-704	154	18	°	°	NOUN
admet-704	154	19	c	c	X
admet-704	154	20	.	.	PUNCT
admet-704	155	1	solubility	solubility	NOUN
admet-704	155	2	(	(	PUNCT
admet-704	155	3	g	g	PROPN
admet-704	155	4	/	/	SYM
admet-704	155	5	ml	ml	NOUN
admet-704	155	6	)	)	PUNCT
admet-704	155	7	(	(	PUNCT
admet-704	155	8	log	log	NOUN
admet-704	155	9	,	,	PUNCT
admet-704	155	10	m	m	NOUN
admet-704	155	11	)	)	PUNCT
admet-704	155	12	compound	compound	NOUN
admet-704	155	13	nonhps	nonhps	NOUN
admet-704	155	14	hp	hp	PROPN
admet-704	156	1	diss	diss	VERB
admet-704	156	2	literature	literature	NOUN
admet-704	156	3	nonhps	nonhps	NOUN
admet-704	156	4	hp	hp	PROPN
admet-704	157	1	diss	diss	PROPN
admet-704	157	2	literature	literature	NOUN
admet-704	157	3	albendazole	albendazole	NOUN
admet-704	157	4	1.02	1.02	NUM
admet-704	157	5	0.86	0.86	NUM
admet-704	157	6	0.69	0.69	NUM
admet-704	157	7	0.86	0.86	NUM
admet-704	157	8	a	a	DET
admet-704	157	9	-5.41	-5.41	NOUN
admet-704	157	10	-5.49	-5.49	NOUN
admet-704	157	11	-5.58	-5.58	NOUN
admet-704	158	1	-5.49	-5.49	NOUN
admet-704	158	2	griseofulvin	griseofulvin	NOUN
admet-704	158	3	11	11	NUM
admet-704	158	4	12	12	NUM
admet-704	158	5	13	13	NUM
admet-704	158	6	15	15	NUM
admet-704	158	7	b	b	SYM
admet-704	158	8	-4.51	-4.51	PRON
admet-704	158	9	-4.47	-4.47	PROPN
admet-704	158	10	-4.43	-4.43	NUM
admet-704	158	11	-4.36	-4.36	NUM
admet-704	158	12	dipyridamole	dipyridamole	NOUN
admet-704	158	13	3.5	3.5	NUM
admet-704	158	14	4.7	4.7	NUM
admet-704	158	15	5.2	5.2	NUM
admet-704	158	16	5.7	5.7	NUM
admet-704	158	17	c	c	NOUN
admet-704	158	18	-5.17	-5.17	PRON
admet-704	158	19	-5.03	-5.03	NOUN
admet-704	158	20	-4.99	-4.99	NUM
admet-704	158	21	-4.95	-4.95	NOUN
admet-704	158	22	glibenclamide	glibenclamide	NOUN
admet-704	158	23	3.4	3.4	NUM
admet-704	158	24	4.9	4.9	NUM
admet-704	158	25	5.5	5.5	NUM
admet-704	158	26	7.0	7.0	NUM
admet-704	158	27	d	d	NOUN
admet-704	158	28	-5.16	-5.16	PROPN
admet-704	158	29	-5.00	-5.00	NUM
admet-704	158	30	-4.95	-4.95	PROPN
admet-704	158	31	-4.85	-4.85	X
admet-704	158	32	a	a	DET
admet-704	158	33	reference	reference	NOUN
admet-704	158	34	[	[	X
admet-704	158	35	32	32	NUM
admet-704	158	36	-	-	SYM
admet-704	158	37	35	35	NUM
admet-704	158	38	]	]	PUNCT
admet-704	158	39	b	b	NOUN
admet-704	158	40	reference	reference	NOUN
admet-704	158	41	[	[	X
admet-704	158	42	35	35	NUM
admet-704	158	43	-	-	SYM
admet-704	158	44	37	37	NUM
admet-704	158	45	]	]	PUNCT
admet-704	158	46	c	c	NOUN
admet-704	158	47	reference	reference	NOUN
admet-704	158	48	[	[	X
admet-704	158	49	35	35	NUM
admet-704	158	50	-	-	SYM
admet-704	158	51	37	37	NUM
admet-704	158	52	]	]	PUNCT
admet-704	158	53	d	d	X
admet-704	158	54	reference	reference	NOUN
admet-704	158	55	[	[	X
admet-704	158	56	32	32	NUM
admet-704	158	57	,	,	PUNCT
admet-704	158	58	34	34	NUM
admet-704	158	59	,	,	PUNCT
admet-704	158	60	35	35	NUM
admet-704	158	61	,	,	PUNCT
admet-704	158	62	38	38	NUM
admet-704	158	63	]	]	PUNCT
admet-704	158	64	figure	figure	NOUN
admet-704	158	65	6	6	NUM
admet-704	158	66	comparison	comparison	NOUN
admet-704	158	67	of	of	ADP
admet-704	158	68	equilibrium	equilibrium	NOUN
admet-704	158	69	solubility	solubility	NOUN
admet-704	158	70	at	at	ADP
admet-704	158	71	ph	ph	PROPN
admet-704	158	72	6.8	6.8	NUM
admet-704	158	73	,	,	PUNCT
admet-704	158	74	37	37	NUM
admet-704	158	75	°	°	NUM
admet-704	158	76	c	c	NOUN
admet-704	158	77	of	of	ADP
admet-704	158	78	model	model	NOUN
admet-704	158	79	drugs	drug	NOUN
admet-704	158	80	obtained	obtain	VERB
admet-704	158	81	by	by	ADP
admet-704	158	82	different	different	ADJ
admet-704	158	83	methods	method	NOUN
admet-704	158	84	.	.	PUNCT
admet-704	159	1	in	in	ADP
admet-704	159	2	this	this	DET
admet-704	159	3	study	study	NOUN
admet-704	159	4	,	,	PUNCT
admet-704	159	5	the	the	DET
admet-704	159	6	ph	ph	NOUN
admet-704	159	7	value	value	NOUN
admet-704	159	8	did	do	AUX
admet-704	159	9	not	not	PART
admet-704	159	10	change	change	VERB
admet-704	159	11	during	during	ADP
admet-704	159	12	incubation	incubation	NOUN
admet-704	159	13	,	,	PUNCT
admet-704	159	14	because	because	SCONJ
admet-704	159	15	the	the	DET
admet-704	159	16	drug	drug	NOUN
admet-704	159	17	concentration	concentration	NOUN
admet-704	159	18	was	be	AUX
admet-704	159	19	set	set	VERB
admet-704	159	20	to	to	ADP
admet-704	159	21	about	about	ADV
admet-704	159	22	1	1	NUM
admet-704	159	23	mg	mg	NUM
admet-704	159	24	/	/	SYM
admet-704	159	25	ml	ml	PROPN
admet-704	159	26	(	(	PUNCT
admet-704	159	27	as	as	ADP
admet-704	159	28	of	of	ADP
admet-704	159	29	added	add	VERB
admet-704	159	30	solids	solid	NOUN
admet-704	159	31	)	)	PUNCT
admet-704	159	32	and	and	CCONJ
admet-704	159	33	the	the	DET
admet-704	159	34	buffer	buffer	NOUN
admet-704	159	35	capacity	capacity	NOUN
admet-704	159	36	was	be	AUX
admet-704	159	37	set	set	VERB
admet-704	159	38	to	to	PART
admet-704	159	39	be	be	AUX
admet-704	159	40	sufficient	sufficient	ADJ
admet-704	159	41	.	.	PUNCT
admet-704	160	1	however	however	ADV
admet-704	160	2	,	,	PUNCT
admet-704	160	3	in	in	ADP
admet-704	160	4	the	the	DET
admet-704	160	5	case	case	NOUN
admet-704	160	6	when	when	SCONJ
admet-704	160	7	a	a	DET
admet-704	160	8	large	large	ADJ
admet-704	160	9	amount	amount	NOUN
admet-704	160	10	of	of	ADP
admet-704	160	11	a	a	DET
admet-704	160	12	drug	drug	NOUN
admet-704	160	13	and/or	and/or	CCONJ
admet-704	160	14	a	a	DET
admet-704	160	15	buffer	buffer	NOUN
admet-704	160	16	with	with	ADP
admet-704	160	17	limited	limited	ADJ
admet-704	160	18	buffer	buffer	NOUN
admet-704	160	19	capacity	capacity	NOUN
admet-704	160	20	are	be	AUX
admet-704	160	21	used	use	VERB
admet-704	160	22	,	,	PUNCT
admet-704	160	23	the	the	DET
admet-704	160	24	final	final	ADJ
admet-704	160	25	ph	ph	NOUN
admet-704	160	26	after	after	SCONJ
admet-704	160	27	incubation	incubation	NOUN
admet-704	160	28	would	would	AUX
admet-704	160	29	be	be	AUX
admet-704	160	30	different	different	ADJ
admet-704	160	31	from	from	ADP
admet-704	160	32	the	the	DET
admet-704	160	33	initial	initial	ADJ
admet-704	160	34	ph	ph	NOUN
admet-704	160	35	.	.	PUNCT
admet-704	161	1	it	it	PRON
admet-704	161	2	should	should	AUX
admet-704	161	3	be	be	AUX
admet-704	161	4	noted	note	VERB
admet-704	161	5	that	that	SCONJ
admet-704	161	6	even	even	ADV
admet-704	161	7	when	when	SCONJ
admet-704	161	8	starting	start	VERB
admet-704	161	9	with	with	ADP
admet-704	161	10	a	a	DET
admet-704	161	11	salt	salt	NOUN
admet-704	161	12	form	form	NOUN
admet-704	161	13	,	,	PUNCT
admet-704	161	14	at	at	ADP
admet-704	161	15	the	the	DET
admet-704	161	16	neutral	neutral	ADJ
admet-704	161	17	ph	ph	ADJ
admet-704	161	18	region	region	NOUN
admet-704	161	19	,	,	PUNCT
admet-704	161	20	the	the	DET
admet-704	161	21	residual	residual	ADJ
admet-704	161	22	solids	solid	NOUN
admet-704	161	23	become	become	VERB
admet-704	161	24	a	a	DET
admet-704	161	25	free	free	ADJ
admet-704	161	26	form	form	NOUN
admet-704	161	27	after	after	ADP
admet-704	161	28	achieving	achieve	VERB
admet-704	161	29	equilibrium	equilibrium	NOUN
admet-704	161	30	if	if	SCONJ
admet-704	161	31	the	the	DET
admet-704	161	32	ph	ph	NOUN
admet-704	161	33	is	be	AUX
admet-704	161	34	below	below	ADV
admet-704	161	35	(	(	PUNCT
admet-704	161	36	for	for	ADP
admet-704	161	37	acids	acid	NOUN
admet-704	161	38	)	)	PUNCT
admet-704	161	39	or	or	CCONJ
admet-704	161	40	above	above	ADV
admet-704	161	41	(	(	PUNCT
admet-704	161	42	for	for	ADP
admet-704	161	43	bases	basis	NOUN
admet-704	161	44	)	)	PUNCT
admet-704	161	45	the	the	DET
admet-704	161	46	phmax	phmax	NOUN
admet-704	161	47	(	(	PUNCT
admet-704	161	48	the	the	DET
admet-704	161	49	ph	ph	NOUN
admet-704	161	50	where	where	SCONJ
admet-704	161	51	the	the	DET
admet-704	161	52	system	system	NOUN
admet-704	161	53	changes	change	VERB
admet-704	161	54	from	from	ADP
admet-704	161	55	the	the	DET
admet-704	161	56	phcontrolled	phcontrolled	ADJ
admet-704	161	57	region	region	NOUN
admet-704	161	58	to	to	ADP
admet-704	161	59	the	the	DET
admet-704	161	60	common	common	ADJ
admet-704	161	61	-	-	PUNCT
admet-704	161	62	ion	ion	NOUN
admet-704	161	63	-	-	PUNCT
admet-704	161	64	effect	effect	NOUN
admet-704	161	65	-	-	PUNCT
admet-704	161	66	controlled	control	VERB
admet-704	161	67	region	region	NOUN
admet-704	161	68	)	)	PUNCT
admet-704	161	69	.	.	PUNCT
admet-704	162	1	therefore	therefore	ADV
admet-704	162	2	,	,	PUNCT
admet-704	162	3	the	the	DET
admet-704	162	4	observed	observed	ADJ
admet-704	162	5	solubility	solubility	NOUN
admet-704	162	6	becomes	become	VERB
admet-704	162	7	the	the	DET
admet-704	162	8	same	same	ADJ
admet-704	162	9	regardless	regardless	ADV
admet-704	162	10	of	of	ADP
admet-704	162	11	the	the	DET
admet-704	162	12	starting	starting	NOUN
admet-704	162	13	material	material	NOUN
admet-704	162	14	being	be	AUX
admet-704	162	15	a	a	DET
admet-704	162	16	salt	salt	NOUN
admet-704	162	17	or	or	CCONJ
admet-704	162	18	a	a	DET
admet-704	162	19	free	free	ADJ
admet-704	162	20	form	form	NOUN
admet-704	162	21	if	if	SCONJ
admet-704	162	22	the	the	DET
admet-704	162	23	solution	solution	NOUN
admet-704	162	24	is	be	AUX
admet-704	162	25	well	well	ADV
admet-704	162	26	-	-	PUNCT
admet-704	162	27	buffered	buffer	VERB
admet-704	162	28	to	to	PART
admet-704	162	29	maintain	maintain	VERB
admet-704	162	30	the	the	DET
admet-704	162	31	ph	ph	NOUN
admet-704	162	32	(	(	PUNCT
admet-704	162	33	unless	unless	SCONJ
admet-704	162	34	there	there	PRON
admet-704	162	35	is	be	VERB
admet-704	162	36	a	a	DET
admet-704	162	37	difference	difference	NOUN
admet-704	162	38	in	in	ADP
admet-704	162	39	the	the	DET
admet-704	162	40	solid	solid	ADJ
admet-704	162	41	forms	form	NOUN
admet-704	162	42	of	of	ADP
admet-704	162	43	residual	residual	ADJ
admet-704	162	44	free	free	ADJ
admet-704	162	45	form	form	NOUN
admet-704	162	46	solids	solid	NOUN
admet-704	162	47	)	)	PUNCT
admet-704	162	48	.	.	PUNCT
admet-704	163	1	this	this	DET
admet-704	163	2	point	point	NOUN
admet-704	163	3	is	be	AUX
admet-704	163	4	often	often	ADV
admet-704	163	5	misunderstood	misunderstood	ADJ
admet-704	163	6	by	by	ADP
admet-704	163	7	pharmacokinetic	pharmacokinetic	ADJ
admet-704	163	8	scientists	scientist	NOUN
admet-704	163	9	who	who	PRON
admet-704	163	10	perform	perform	VERB
admet-704	163	11	computational	computational	ADJ
admet-704	163	12	oral	oral	ADJ
admet-704	163	13	absorption	absorption	NOUN
admet-704	163	14	simulation	simulation	NOUN
admet-704	163	15	for	for	ADP
admet-704	163	16	a	a	DET
admet-704	163	17	salt	salt	NOUN
admet-704	163	18	form	form	NOUN
admet-704	163	19	drug	drug	NOUN
admet-704	163	20	substance	substance	NOUN
admet-704	163	21	.	.	PUNCT
admet-704	164	1	the	the	DET
admet-704	164	2	dissolution	dissolution	NOUN
admet-704	164	3	of	of	ADP
admet-704	164	4	a	a	DET
admet-704	164	5	salt	salt	NOUN
admet-704	164	6	and	and	CCONJ
admet-704	164	7	the	the	DET
admet-704	164	8	supersaturation	supersaturation	NOUN
admet-704	164	9	and	and	CCONJ
admet-704	164	10	phase	phase	NOUN
admet-704	164	11	separation	separation	NOUN
admet-704	164	12	of	of	ADP
admet-704	164	13	a	a	DET
admet-704	164	14	free	free	ADJ
admet-704	164	15	form	form	NOUN
admet-704	164	16	must	must	AUX
admet-704	164	17	be	be	AUX
admet-704	164	18	taken	take	VERB
admet-704	164	19	into	into	ADP
admet-704	164	20	account	account	NOUN
admet-704	164	21	to	to	PART
admet-704	164	22	simulate	simulate	VERB
admet-704	164	23	the	the	DET
admet-704	164	24	oral	oral	ADJ
admet-704	164	25	absorption	absorption	NOUN
admet-704	164	26	of	of	ADP
admet-704	164	27	the	the	DET
admet-704	164	28	drug	drug	NOUN
admet-704	164	29	.	.	PUNCT
admet-704	165	1	the	the	DET
admet-704	165	2	ksp	ksp	PROPN
admet-704	165	3	(	(	PUNCT
admet-704	165	4	the	the	DET
admet-704	165	5	drug	drug	NOUN
admet-704	165	6	-	-	PUNCT
admet-704	165	7	salt	salt	NOUN
admet-704	165	8	solubility	solubility	NOUN
admet-704	165	9	product	product	NOUN
admet-704	165	10	)	)	PUNCT
admet-704	165	11	value	value	NOUN
admet-704	165	12	is	be	AUX
admet-704	165	13	at	at	ADP
admet-704	165	14	least	least	ADJ
admet-704	165	15	required	require	VERB
admet-704	165	16	to	to	PART
admet-704	165	17	simulate	simulate	VERB
admet-704	165	18	the	the	DET
admet-704	165	19	dissolution	dissolution	NOUN
admet-704	165	20	of	of	ADP
admet-704	165	21	a	a	DET
admet-704	165	22	salt	salt	NOUN
admet-704	165	23	.	.	PUNCT
admet-704	166	1	however	however	ADV
admet-704	166	2	,	,	PUNCT
admet-704	166	3	the	the	DET
admet-704	166	4	dissolution	dissolution	ADJ
admet-704	166	5	mechanisms	mechanism	NOUN
admet-704	166	6	of	of	ADP
admet-704	166	7	a	a	DET
admet-704	166	8	salt	salt	NOUN
admet-704	166	9	are	be	AUX
admet-704	166	10	not	not	PART
admet-704	166	11	fully	fully	ADV
admet-704	166	12	understood	understand	VERB
admet-704	166	13	,	,	PUNCT
admet-704	166	14	especially	especially	ADV
admet-704	166	15	the	the	DET
admet-704	166	16	chemical	chemical	ADJ
admet-704	166	17	reactions	reaction	NOUN
admet-704	166	18	in	in	ADP
admet-704	166	19	the	the	DET
admet-704	166	20	unstirred	unstirred	ADJ
admet-704	166	21	water	water	NOUN
admet-704	166	22	layer	layer	NOUN
admet-704	167	1	[	[	X
admet-704	167	2	50	50	NUM
admet-704	167	3	,	,	PUNCT
admet-704	167	4	51	51	NUM
admet-704	167	5	]	]	PUNCT
admet-704	167	6	.	.	PUNCT
admet-704	168	1	it	it	PRON
admet-704	168	2	is	be	AUX
admet-704	168	3	highly	highly	ADV
admet-704	168	4	recommended	recommend	VERB
admet-704	168	5	to	to	PART
admet-704	168	6	analyse	analyse	VERB
admet-704	168	7	the	the	DET
admet-704	168	8	solid	solid	ADJ
admet-704	168	9	forms	form	NOUN
admet-704	168	10	of	of	ADP
admet-704	168	11	both	both	PRON
admet-704	168	12	initial	initial	ADJ
admet-704	168	13	and	and	CCONJ
admet-704	168	14	residual	residual	ADJ
admet-704	168	15	solids	solid	NOUN
admet-704	168	16	.	.	PUNCT
admet-704	169	1	in	in	ADP
admet-704	169	2	drug	drug	NOUN
admet-704	169	3	discovery	discovery	NOUN
admet-704	169	4	,	,	PUNCT
admet-704	169	5	little	little	ADJ
admet-704	169	6	information	information	NOUN
admet-704	169	7	about	about	ADP
admet-704	169	8	polymorphs	polymorphs	NOUN
admet-704	169	9	and	and	CCONJ
admet-704	169	10	pseudo	pseudo	NOUN
admet-704	169	11	-	-	NOUN
admet-704	169	12	polymorphs	polymorphs	NOUN
admet-704	169	13	is	be	AUX
admet-704	169	14	available	available	ADJ
admet-704	169	15	.	.	PUNCT
admet-704	170	1	therefore	therefore	ADV
admet-704	170	2	,	,	PUNCT
admet-704	170	3	the	the	DET
admet-704	170	4	information	information	NOUN
admet-704	170	5	about	about	ADP
admet-704	170	6	asami	asami	PROPN
admet-704	170	7	ono	ono	PROPN
admet-704	170	8	et	et	PROPN
admet-704	170	9	.	.	PUNCT
admet-704	171	1	al	al	PROPN
admet-704	171	2	admet	admet	PROPN
admet-704	171	3	&	&	CCONJ
admet-704	171	4	dmpk	dmpk	PROPN
admet-704	171	5	7(3	7(3	NUM
admet-704	171	6	)	)	PUNCT
admet-704	171	7	(	(	PUNCT
admet-704	171	8	2019	2019	NUM
admet-704	171	9	)	)	PUNCT
admet-704	171	10	183	183	NUM
admet-704	171	11	-	-	SYM
admet-704	171	12	195	195	NUM
admet-704	171	13	192	192	NUM
admet-704	171	14	the	the	DET
admet-704	171	15	solid	solid	ADJ
admet-704	171	16	form	form	NOUN
admet-704	171	17	obtained	obtain	VERB
admet-704	171	18	along	along	ADP
admet-704	171	19	with	with	ADP
admet-704	171	20	the	the	DET
admet-704	171	21	solubility	solubility	NOUN
admet-704	171	22	data	datum	NOUN
admet-704	171	23	is	be	AUX
admet-704	171	24	important	important	ADJ
admet-704	171	25	for	for	ADP
admet-704	171	26	further	further	ADJ
admet-704	171	27	solid	solid	ADJ
admet-704	171	28	form	form	NOUN
admet-704	171	29	characterization	characterization	NOUN
admet-704	171	30	.	.	PUNCT
admet-704	172	1	for	for	ADP
admet-704	172	2	the	the	DET
admet-704	172	3	assessment	assessment	NOUN
admet-704	172	4	of	of	ADP
admet-704	172	5	drug	drug	NOUN
admet-704	172	6	solubility	solubility	NOUN
admet-704	172	7	in	in	ADP
admet-704	172	8	physiological	physiological	ADJ
admet-704	172	9	gastrointestinal	gastrointestinal	ADJ
admet-704	172	10	conditions	condition	NOUN
admet-704	172	11	,	,	PUNCT
admet-704	172	12	an	an	DET
admet-704	172	13	hcl	hcl	PROPN
admet-704	172	14	solution	solution	NOUN
admet-704	172	15	of	of	ADP
admet-704	172	16	ph	ph	ADJ
admet-704	172	17	1	1	NUM
admet-704	172	18	to	to	PART
admet-704	172	19	2	2	NUM
admet-704	172	20	is	be	AUX
admet-704	172	21	often	often	ADV
admet-704	172	22	used	use	VERB
admet-704	172	23	.	.	PUNCT
admet-704	173	1	in	in	ADP
admet-704	173	2	an	an	DET
admet-704	173	3	hcl	hcl	PROPN
admet-704	173	4	solution	solution	NOUN
admet-704	173	5	,	,	PUNCT
admet-704	173	6	the	the	DET
admet-704	173	7	solubility	solubility	NOUN
admet-704	173	8	of	of	ADP
admet-704	173	9	a	a	DET
admet-704	173	10	drug	drug	NOUN
admet-704	173	11	is	be	AUX
admet-704	173	12	often	often	ADV
admet-704	173	13	controlled	control	VERB
admet-704	173	14	by	by	ADP
admet-704	173	15	the	the	DET
admet-704	173	16	common	common	ADJ
admet-704	173	17	ionic	ionic	ADJ
admet-704	173	18	effect	effect	NOUN
admet-704	173	19	of	of	ADP
admet-704	173	20	the	the	DET
admet-704	173	21	chloride	chloride	NOUN
admet-704	173	22	ion	ion	NOUN
admet-704	173	23	.	.	PUNCT
admet-704	174	1	in	in	ADP
admet-704	174	2	this	this	DET
admet-704	174	3	case	case	NOUN
admet-704	174	4	,	,	PUNCT
admet-704	174	5	the	the	DET
admet-704	174	6	residual	residual	ADJ
admet-704	174	7	solid	solid	ADJ
admet-704	174	8	after	after	SCONJ
admet-704	174	9	the	the	DET
admet-704	174	10	solubility	solubility	NOUN
admet-704	174	11	measurement	measurement	NOUN
admet-704	174	12	becomes	become	VERB
admet-704	174	13	an	an	DET
admet-704	174	14	hcl	hcl	PROPN
admet-704	174	15	salt	salt	NOUN
admet-704	174	16	.	.	PUNCT
admet-704	175	1	in	in	ADP
admet-704	175	2	addition	addition	NOUN
admet-704	175	3	,	,	PUNCT
admet-704	175	4	attention	attention	NOUN
admet-704	175	5	should	should	AUX
admet-704	175	6	be	be	AUX
admet-704	175	7	paid	pay	VERB
admet-704	175	8	to	to	ADP
admet-704	175	9	the	the	DET
admet-704	175	10	formation	formation	NOUN
admet-704	175	11	of	of	ADP
admet-704	175	12	soluble	soluble	ADJ
admet-704	175	13	drug	drug	NOUN
admet-704	175	14	-	-	PUNCT
admet-704	175	15	buffer	buffer	NOUN
admet-704	175	16	complexes	complex	NOUN
admet-704	175	17	or	or	CCONJ
admet-704	175	18	insoluble	insoluble	ADJ
admet-704	175	19	drugbuffer	drugbuffer	NOUN
admet-704	175	20	precipitates	precipitate	NOUN
admet-704	175	21	in	in	ADP
admet-704	175	22	a	a	DET
admet-704	175	23	phosphate	phosphate	ADJ
admet-704	175	24	buffer	buffer	NOUN
admet-704	175	25	for	for	ADP
admet-704	175	26	basic	basic	ADJ
admet-704	175	27	drugs	drug	NOUN
admet-704	175	28	[	[	X
admet-704	175	29	52	52	NUM
admet-704	175	30	,	,	PUNCT
admet-704	175	31	53	53	NUM
admet-704	175	32	]	]	PUNCT
admet-704	175	33	.	.	PUNCT
admet-704	176	1	the	the	DET
admet-704	176	2	analysis	analysis	NOUN
admet-704	176	3	of	of	ADP
admet-704	176	4	the	the	DET
admet-704	176	5	residual	residual	ADJ
admet-704	176	6	solid	solid	ADJ
admet-704	176	7	after	after	SCONJ
admet-704	176	8	solubility	solubility	NOUN
admet-704	176	9	measurements	measurement	NOUN
admet-704	176	10	can	can	AUX
admet-704	176	11	clarify	clarify	VERB
admet-704	176	12	the	the	DET
admet-704	176	13	formation	formation	NOUN
admet-704	176	14	of	of	ADP
admet-704	176	15	insoluble	insoluble	ADJ
admet-704	176	16	drug	drug	NOUN
admet-704	176	17	-	-	PUNCT
admet-704	176	18	buffer	buffer	NOUN
admet-704	176	19	precipitates	precipitate	NOUN
admet-704	176	20	.	.	PUNCT
admet-704	177	1	the	the	DET
admet-704	177	2	harmonized	harmonized	ADJ
admet-704	177	3	protocol	protocol	NOUN
admet-704	177	4	would	would	AUX
admet-704	177	5	be	be	AUX
admet-704	177	6	suitable	suitable	ADJ
admet-704	177	7	for	for	ADP
admet-704	177	8	solubility	solubility	NOUN
admet-704	177	9	measurements	measurement	NOUN
admet-704	177	10	at	at	ADP
admet-704	177	11	the	the	DET
admet-704	177	12	preclinical	preclinical	ADJ
admet-704	177	13	stages	stage	NOUN
admet-704	177	14	,	,	PUNCT
admet-704	177	15	e.g.	e.g.	ADV
admet-704	177	16	,	,	PUNCT
admet-704	177	17	the	the	DET
admet-704	177	18	late	late	ADJ
admet-704	177	19	lead	lead	NOUN
admet-704	177	20	optimization	optimization	NOUN
admet-704	177	21	and	and	CCONJ
admet-704	177	22	pre	pre	ADJ
admet-704	177	23	-	-	NOUN
admet-704	177	24	formulation	formulation	NOUN
admet-704	177	25	stages	stage	NOUN
admet-704	177	26	.	.	PUNCT
admet-704	178	1	we	we	PRON
admet-704	178	2	successfully	successfully	ADV
admet-704	178	3	predicted	predict	VERB
admet-704	178	4	the	the	DET
admet-704	178	5	oral	oral	ADJ
admet-704	178	6	absorption	absorption	NOUN
admet-704	178	7	of	of	ADP
admet-704	178	8	proprietary	proprietary	ADJ
admet-704	178	9	drug	drug	NOUN
admet-704	178	10	candidates	candidate	NOUN
admet-704	178	11	in	in	ADP
admet-704	178	12	dogs	dog	NOUN
admet-704	178	13	using	use	VERB
admet-704	178	14	the	the	DET
admet-704	178	15	solubility	solubility	NOUN
admet-704	178	16	data	datum	NOUN
admet-704	178	17	measured	measure	VERB
admet-704	178	18	by	by	ADP
admet-704	178	19	the	the	DET
admet-704	178	20	hp	hp	PROPN
admet-704	178	21	[	[	X
admet-704	178	22	54	54	NUM
admet-704	178	23	]	]	PUNCT
admet-704	178	24	.	.	PUNCT
admet-704	179	1	it	it	PRON
admet-704	179	2	should	should	AUX
admet-704	179	3	be	be	AUX
admet-704	179	4	noted	note	VERB
admet-704	179	5	that	that	SCONJ
admet-704	179	6	the	the	DET
admet-704	179	7	solid	solid	ADJ
admet-704	179	8	form	form	NOUN
admet-704	179	9	may	may	AUX
admet-704	179	10	change	change	VERB
admet-704	179	11	during	during	ADP
admet-704	179	12	the	the	DET
admet-704	179	13	preparation	preparation	NOUN
admet-704	179	14	of	of	ADP
admet-704	179	15	a	a	DET
admet-704	179	16	suspension	suspension	NOUN
admet-704	179	17	formulation	formulation	NOUN
admet-704	179	18	for	for	ADP
admet-704	179	19	a	a	DET
admet-704	179	20	preclinical	preclinical	NOUN
admet-704	179	21	in	in	ADP
admet-704	179	22	vivo	vivo	NOUN
admet-704	179	23	study	study	NOUN
admet-704	179	24	.	.	PUNCT
admet-704	180	1	conclusions	conclusion	NOUN
admet-704	180	2	in	in	ADP
admet-704	180	3	conclusion	conclusion	NOUN
admet-704	180	4	,	,	PUNCT
admet-704	180	5	this	this	DET
admet-704	180	6	study	study	NOUN
admet-704	180	7	demonstrated	demonstrate	VERB
admet-704	180	8	that	that	SCONJ
admet-704	180	9	the	the	DET
admet-704	180	10	inter	inter	ADJ
admet-704	180	11	-	-	ADJ
admet-704	180	12	laboratory	laboratory	ADJ
admet-704	180	13	variance	variance	NOUN
admet-704	180	14	was	be	AUX
admet-704	180	15	successfully	successfully	ADV
admet-704	180	16	reduced	reduce	VERB
admet-704	180	17	by	by	ADP
admet-704	180	18	applying	apply	VERB
admet-704	180	19	the	the	DET
admet-704	180	20	harmonized	harmonized	ADJ
admet-704	180	21	solubility	solubility	NOUN
admet-704	180	22	protocol	protocol	NOUN
admet-704	180	23	.	.	PUNCT
admet-704	181	1	the	the	DET
admet-704	181	2	harmonized	harmonized	ADJ
admet-704	181	3	protocol	protocol	NOUN
admet-704	181	4	proposed	propose	VERB
admet-704	181	5	in	in	ADP
admet-704	181	6	this	this	DET
admet-704	181	7	study	study	NOUN
admet-704	181	8	is	be	AUX
admet-704	181	9	practically	practically	ADV
admet-704	181	10	applicable	applicable	ADJ
admet-704	181	11	to	to	ADP
admet-704	181	12	drug	drug	NOUN
admet-704	181	13	discovery	discovery	NOUN
admet-704	181	14	and	and	CCONJ
admet-704	181	15	development	development	NOUN
admet-704	181	16	.	.	PUNCT
admet-704	182	1	acknowledgements	acknowledgement	NOUN
admet-704	182	2	:	:	PUNCT
admet-704	182	3	this	this	DET
admet-704	182	4	study	study	NOUN
admet-704	182	5	was	be	AUX
admet-704	182	6	conducted	conduct	VERB
admet-704	182	7	as	as	ADP
admet-704	182	8	part	part	NOUN
admet-704	182	9	of	of	ADP
admet-704	182	10	the	the	DET
admet-704	182	11	consortium	consortium	NOUN
admet-704	182	12	for	for	ADP
admet-704	182	13	biopharmaceutics	biopharmaceutics	NOUN
admet-704	182	14	tools	tool	NOUN
admet-704	182	15	(	(	PUNCT
admet-704	182	16	cobito	cobito	ADJ
admet-704	182	17	)	)	PUNCT
admet-704	182	18	in	in	ADP
admet-704	182	19	research	research	NOUN
admet-704	182	20	center	center	NOUN
admet-704	182	21	for	for	ADP
admet-704	182	22	drug	drug	NOUN
admet-704	182	23	discovery	discovery	NOUN
admet-704	182	24	and	and	CCONJ
admet-704	182	25	pharmaceutical	pharmaceutical	NOUN
admet-704	182	26	development	development	NOUN
admet-704	182	27	science	science	NOUN
admet-704	182	28	of	of	ADP
admet-704	182	29	ritsumeikan	ritsumeikan	PROPN
admet-704	182	30	university	university	NOUN
admet-704	182	31	.	.	PUNCT
admet-704	183	1	kiyohiko	kiyohiko	PROPN
admet-704	183	2	sugano	sugano	PROPN
admet-704	183	3	is	be	AUX
admet-704	183	4	the	the	DET
admet-704	183	5	founder	founder	NOUN
admet-704	183	6	of	of	ADP
admet-704	183	7	bioavailabilitydesign	bioavailabilitydesign	PROPN
admet-704	183	8	llc	llc	PROPN
admet-704	183	9	.	.	PUNCT
admet-704	184	1	conflict	conflict	NOUN
admet-704	184	2	of	of	ADP
admet-704	184	3	interest	interest	NOUN
admet-704	184	4	:	:	PUNCT
admet-704	184	5	there	there	PRON
admet-704	184	6	is	be	VERB
admet-704	184	7	no	no	DET
admet-704	184	8	conflict	conflict	NOUN
admet-704	184	9	of	of	ADP
admet-704	184	10	interest	interest	NOUN
admet-704	184	11	in	in	ADP
admet-704	184	12	the	the	DET
admet-704	184	13	work	work	NOUN
admet-704	184	14	presented	present	VERB
admet-704	184	15	.	.	PUNCT
admet-704	185	1	references	reference	NOUN
admet-704	185	2	[	[	X
admet-704	185	3	1	1	NUM
admet-704	185	4	]	]	PUNCT
admet-704	185	5	c.	c.	PROPN
admet-704	185	6	a.	a.	PROPN
admet-704	185	7	lipinski	lipinski	PROPN
admet-704	185	8	.	.	PUNCT
admet-704	186	1	drug	drug	NOUN
admet-704	186	2	-	-	PUNCT
admet-704	186	3	like	like	ADJ
admet-704	186	4	properties	property	NOUN
admet-704	186	5	and	and	CCONJ
admet-704	186	6	the	the	DET
admet-704	186	7	causes	cause	NOUN
admet-704	186	8	of	of	ADP
admet-704	186	9	poor	poor	ADJ
admet-704	186	10	solubility	solubility	NOUN
admet-704	186	11	and	and	CCONJ
admet-704	186	12	poor	poor	ADJ
admet-704	186	13	permeability	permeability	NOUN
admet-704	186	14	.	.	PUNCT
admet-704	187	1	j.	j.	PROPN
admet-704	187	2	pharmacol	pharmacol	PROPN
admet-704	187	3	.	.	PUNCT
admet-704	188	1	toxicol	toxicol	PROPN
admet-704	188	2	.	.	PUNCT
admet-704	189	1	methods	method	NOUN
admet-704	189	2	44	44	NUM
admet-704	189	3	(	(	PUNCT
admet-704	189	4	2000	2000	NUM
admet-704	189	5	)	)	PUNCT
admet-704	189	6	235	235	NUM
admet-704	189	7	-	-	SYM
admet-704	189	8	249	249	NUM
admet-704	189	9	.	.	PUNCT
admet-704	190	1	[	[	X
admet-704	190	2	2	2	NUM
admet-704	190	3	]	]	PUNCT
admet-704	190	4	m.	m.	NOUN
admet-704	190	5	m.	m.	NOUN
admet-704	190	6	hann	hann	PROPN
admet-704	190	7	,	,	PUNCT
admet-704	190	8	g.	g.	PROPN
admet-704	190	9	m.	m.	PROPN
admet-704	190	10	keserü	keserü	PROPN
admet-704	190	11	.	.	PUNCT
admet-704	191	1	finding	find	VERB
admet-704	191	2	the	the	DET
admet-704	191	3	sweet	sweet	ADJ
admet-704	191	4	spot	spot	NOUN
admet-704	191	5	:	:	PUNCT
admet-704	191	6	the	the	DET
admet-704	191	7	role	role	NOUN
admet-704	191	8	of	of	ADP
admet-704	191	9	nature	nature	NOUN
admet-704	191	10	and	and	CCONJ
admet-704	191	11	nurture	nurture	VERB
admet-704	191	12	in	in	ADP
admet-704	191	13	medicinal	medicinal	ADJ
admet-704	191	14	chemistry	chemistry	NOUN
admet-704	191	15	.	.	PUNCT
admet-704	192	1	nature	nature	NOUN
admet-704	192	2	reviews	review	VERB
admet-704	192	3	drug	drug	NOUN
admet-704	192	4	discovery	discovery	NOUN
admet-704	192	5	11	11	NUM
admet-704	192	6	(	(	PUNCT
admet-704	192	7	2012	2012	NUM
admet-704	192	8	)	)	PUNCT
admet-704	192	9	355	355	NUM
admet-704	192	10	.	.	PUNCT
admet-704	193	1	[	[	X
admet-704	193	2	3	3	X
admet-704	193	3	]	]	PUNCT
admet-704	193	4	m.	m.	NOUN
admet-704	193	5	j.	j.	PROPN
admet-704	193	6	waring	waring	PROPN
admet-704	193	7	,	,	PUNCT
admet-704	193	8	j.	j.	PROPN
admet-704	193	9	arrowsmith	arrowsmith	PROPN
admet-704	193	10	,	,	PUNCT
admet-704	193	11	a.	a.	PROPN
admet-704	193	12	r.	r.	PROPN
admet-704	193	13	leach	leach	NOUN
admet-704	193	14	,	,	PUNCT
admet-704	193	15	p.	p.	PROPN
admet-704	193	16	d.	d.	PROPN
admet-704	193	17	leeson	leeson	PROPN
admet-704	193	18	,	,	PUNCT
admet-704	193	19	s.	s.	PROPN
admet-704	193	20	mandrell	mandrell	PROPN
admet-704	193	21	,	,	PUNCT
admet-704	193	22	r.	r.	PROPN
admet-704	193	23	m.	m.	PROPN
admet-704	193	24	owen	owen	PROPN
admet-704	193	25	,	,	PUNCT
admet-704	193	26	g.	g.	PROPN
admet-704	193	27	pairaudeau	pairaudeau	PROPN
admet-704	193	28	,	,	PUNCT
admet-704	193	29	w.	w.	PROPN
admet-704	193	30	d.	d.	PROPN
admet-704	193	31	pennie	pennie	PROPN
admet-704	193	32	,	,	PUNCT
admet-704	193	33	s.	s.	PROPN
admet-704	193	34	d.	d.	PROPN
admet-704	193	35	pickett	pickett	PROPN
admet-704	193	36	,	,	PUNCT
admet-704	193	37	j.	j.	PROPN
admet-704	193	38	wang	wang	PROPN
admet-704	193	39	,	,	PUNCT
admet-704	193	40	o.	o.	PROPN
admet-704	193	41	wallace	wallace	PROPN
admet-704	193	42	,	,	PUNCT
admet-704	193	43	a.	a.	PROPN
admet-704	193	44	weir	weir	PROPN
admet-704	193	45	.	.	PUNCT
admet-704	194	1	an	an	DET
admet-704	194	2	analysis	analysis	NOUN
admet-704	194	3	of	of	ADP
admet-704	194	4	the	the	DET
admet-704	194	5	attrition	attrition	NOUN
admet-704	194	6	of	of	ADP
admet-704	194	7	drug	drug	NOUN
admet-704	194	8	candidates	candidate	NOUN
admet-704	194	9	from	from	ADP
admet-704	194	10	four	four	NUM
admet-704	194	11	major	major	ADJ
admet-704	194	12	pharmaceutical	pharmaceutical	ADJ
admet-704	194	13	companies	company	NOUN
admet-704	194	14	.	.	PUNCT
admet-704	195	1	nature	nature	NOUN
admet-704	195	2	reviews	review	VERB
admet-704	195	3	drug	drug	NOUN
admet-704	195	4	discovery	discovery	NOUN
admet-704	195	5	14	14	NUM
admet-704	195	6	(	(	PUNCT
admet-704	195	7	2015	2015	NUM
admet-704	195	8	)	)	PUNCT
admet-704	195	9	475	475	NUM
admet-704	195	10	.	.	PUNCT
admet-704	196	1	[	[	X
admet-704	196	2	4	4	X
admet-704	196	3	]	]	PUNCT
admet-704	196	4	j.	j.	PROPN
admet-704	196	5	dressman	dressman	PROPN
admet-704	196	6	,	,	PUNCT
admet-704	196	7	g.	g.	PROPN
admet-704	196	8	amidon	amidon	PROPN
admet-704	196	9	,	,	PUNCT
admet-704	196	10	d.	d.	PROPN
admet-704	196	11	fleisher	fleisher	PROPN
admet-704	196	12	.	.	PUNCT
admet-704	197	1	absorption	absorption	NOUN
admet-704	197	2	potential	potential	NOUN
admet-704	197	3	:	:	PUNCT
admet-704	197	4	estimating	estimate	VERB
admet-704	197	5	the	the	DET
admet-704	197	6	fraction	fraction	NOUN
admet-704	197	7	absorbed	absorb	VERB
admet-704	197	8	for	for	ADP
admet-704	197	9	orally	orally	ADV
admet-704	197	10	administered	administer	VERB
admet-704	197	11	compounds	compound	NOUN
admet-704	197	12	.	.	PUNCT
admet-704	198	1	j.	j.	PROPN
admet-704	198	2	pharm	pharm	PROPN
admet-704	198	3	.	.	PUNCT
admet-704	199	1	sci	sci	PROPN
admet-704	199	2	.	.	PROPN
admet-704	200	1	74	74	NUM
admet-704	200	2	(	(	PUNCT
admet-704	200	3	1985	1985	NUM
admet-704	200	4	)	)	PUNCT
admet-704	200	5	588	588	NUM
admet-704	200	6	-	-	SYM
admet-704	200	7	589	589	NUM
admet-704	200	8	.	.	PUNCT
admet-704	201	1	[	[	X
admet-704	201	2	5	5	X
admet-704	201	3	]	]	PUNCT
admet-704	201	4	g.	g.	PROPN
admet-704	201	5	amidon	amidon	PROPN
admet-704	201	6	,	,	PUNCT
admet-704	201	7	h.	h.	PROPN
admet-704	201	8	lennernäs	lennernäs	PROPN
admet-704	201	9	,	,	PUNCT
admet-704	201	10	v.	v.	CCONJ
admet-704	201	11	shah	shah	PROPN
admet-704	201	12	,	,	PUNCT
admet-704	201	13	j.	j.	PROPN
admet-704	201	14	crison	crison	PROPN
admet-704	201	15	.	.	PUNCT
admet-704	202	1	a	a	DET
admet-704	202	2	theoretical	theoretical	ADJ
admet-704	202	3	basis	basis	NOUN
admet-704	202	4	for	for	ADP
admet-704	202	5	a	a	DET
admet-704	202	6	biopharmaceutic	biopharmaceutic	ADJ
admet-704	202	7	drug	drug	NOUN
admet-704	202	8	classification	classification	NOUN
admet-704	202	9	:	:	PUNCT
admet-704	202	10	the	the	DET
admet-704	202	11	correlation	correlation	NOUN
admet-704	202	12	of	of	ADP
admet-704	202	13	in	in	ADP
admet-704	202	14	vitro	vitro	X
admet-704	202	15	drug	drug	NOUN
admet-704	202	16	product	product	NOUN
admet-704	202	17	dissolution	dissolution	NOUN
admet-704	202	18	and	and	CCONJ
admet-704	202	19	in	in	ADP
admet-704	202	20	vivo	vivo	ADJ
admet-704	202	21	bioavailability	bioavailability	NOUN
admet-704	202	22	.	.	PUNCT
admet-704	203	1	pharm	pharm	NOUN
admet-704	203	2	.	.	PUNCT
admet-704	204	1	res	re	NOUN
admet-704	204	2	.	.	PROPN
admet-704	205	1	12	12	NUM
admet-704	205	2	(	(	PUNCT
admet-704	205	3	1995	1995	NUM
admet-704	205	4	)	)	PUNCT
admet-704	205	5	413	413	NUM
admet-704	205	6	-	-	SYM
admet-704	205	7	420	420	NUM
admet-704	205	8	.	.	PUNCT
admet-704	206	1	[	[	X
admet-704	206	2	6	6	NUM
admet-704	206	3	]	]	PUNCT
admet-704	206	4	l.	l.	PROPN
admet-704	206	5	yu	yu	PROPN
admet-704	206	6	.	.	PUNCT
admet-704	207	1	an	an	DET
admet-704	207	2	integrated	integrate	VERB
admet-704	207	3	model	model	NOUN
admet-704	207	4	for	for	ADP
admet-704	207	5	determining	determine	VERB
admet-704	207	6	causes	cause	NOUN
admet-704	207	7	of	of	ADP
admet-704	207	8	poor	poor	ADJ
admet-704	207	9	oral	oral	ADJ
admet-704	207	10	drug	drug	NOUN
admet-704	207	11	absorption	absorption	NOUN
admet-704	207	12	.	.	PUNCT
admet-704	208	1	pharm	pharm	NOUN
admet-704	208	2	.	.	PUNCT
admet-704	209	1	res	re	NOUN
admet-704	209	2	.	.	PUNCT
admet-704	210	1	16	16	NUM
admet-704	210	2	(	(	PUNCT
admet-704	210	3	1999	1999	NUM
admet-704	210	4	)	)	PUNCT
admet-704	210	5	1883	1883	NUM
admet-704	210	6	-	-	SYM
admet-704	210	7	1887	1887	NUM
admet-704	210	8	.	.	PUNCT
admet-704	211	1	[	[	X
admet-704	211	2	7	7	X
admet-704	211	3	]	]	PUNCT
admet-704	211	4	k.	k.	PROPN
admet-704	211	5	sugano	sugano	PROPN
admet-704	211	6	.	.	PUNCT
admet-704	212	1	introduction	introduction	NOUN
admet-704	212	2	to	to	ADP
admet-704	212	3	computational	computational	ADJ
admet-704	212	4	oral	oral	ADJ
admet-704	212	5	absorption	absorption	NOUN
admet-704	212	6	simulation	simulation	NOUN
admet-704	212	7	.	.	PUNCT
admet-704	213	1	expert	expert	NOUN
admet-704	213	2	opin	opin	NOUN
admet-704	213	3	.	.	PUNCT
admet-704	214	1	drug	drug	NOUN
admet-704	214	2	metab	metab	NOUN
admet-704	214	3	.	.	PUNCT
admet-704	215	1	toxicol	toxicol	PROPN
admet-704	215	2	.	.	PUNCT
admet-704	216	1	5	5	NUM
admet-704	216	2	(	(	PUNCT
admet-704	216	3	2009	2009	NUM
admet-704	216	4	)	)	PUNCT
admet-704	216	5	259	259	NUM
admet-704	216	6	-	-	SYM
admet-704	216	7	293	293	NUM
admet-704	216	8	.	.	PUNCT
admet-704	217	1	[	[	X
admet-704	217	2	8	8	NUM
admet-704	217	3	]	]	PUNCT
admet-704	217	4	s.	s.	PROPN
admet-704	217	5	venkatesh	venkatesh	PROPN
admet-704	217	6	,	,	PUNCT
admet-704	217	7	r.	r.	PROPN
admet-704	217	8	a.	a.	PROPN
admet-704	217	9	lipper	lipper	PROPN
admet-704	217	10	.	.	PUNCT
admet-704	218	1	role	role	NOUN
admet-704	218	2	of	of	ADP
admet-704	218	3	the	the	DET
admet-704	218	4	development	development	NOUN
admet-704	218	5	scientist	scientist	NOUN
admet-704	218	6	in	in	ADP
admet-704	218	7	compound	compound	NOUN
admet-704	218	8	lead	lead	NOUN
admet-704	218	9	selection	selection	NOUN
admet-704	218	10	and	and	CCONJ
admet-704	218	11	optimization	optimization	NOUN
admet-704	218	12	.	.	PUNCT
admet-704	219	1	j.	j.	PROPN
admet-704	219	2	pharm	pharm	PROPN
admet-704	219	3	.	.	PUNCT
admet-704	220	1	sci	sci	PROPN
admet-704	220	2	.	.	PROPN
admet-704	220	3	89	89	NUM
admet-704	220	4	(	(	PUNCT
admet-704	220	5	2000	2000	NUM
admet-704	220	6	)	)	PUNCT
admet-704	220	7	145	145	NUM
admet-704	220	8	-	-	SYM
admet-704	220	9	154	154	NUM
admet-704	220	10	.	.	PUNCT
admet-704	221	1	[	[	X
admet-704	221	2	9	9	NUM
admet-704	221	3	]	]	PUNCT
admet-704	221	4	v.	v.	PROPN
admet-704	221	5	h.	h.	PROPN
admet-704	221	6	thomas	thomas	PROPN
admet-704	221	7	,	,	PUNCT
admet-704	221	8	s.	s.	PROPN
admet-704	221	9	bhattachar	bhattachar	PROPN
admet-704	221	10	,	,	PUNCT
admet-704	221	11	l.	l.	PROPN
admet-704	221	12	hitchingham	hitchingham	PROPN
admet-704	221	13	,	,	PUNCT
admet-704	221	14	p.	p.	PROPN
admet-704	221	15	zocharski	zocharski	PROPN
admet-704	221	16	,	,	PUNCT
admet-704	221	17	m.	m.	PROPN
admet-704	221	18	naath	naath	PROPN
admet-704	221	19	,	,	PUNCT
admet-704	221	20	n.	n.	PROPN
admet-704	221	21	surendran	surendran	PROPN
admet-704	221	22	,	,	PUNCT
admet-704	221	23	c.	c.	PROPN
admet-704	221	24	l.	l.	PROPN
admet-704	221	25	stoner	stoner	PROPN
admet-704	221	26	,	,	PUNCT
admet-704	221	27	a.	a.	NOUN
admet-704	221	28	elkattan	elkattan	PROPN
admet-704	221	29	.	.	PUNCT
admet-704	222	1	the	the	DET
admet-704	222	2	road	road	NOUN
admet-704	222	3	map	map	NOUN
admet-704	222	4	to	to	ADP
admet-704	222	5	oral	oral	ADJ
admet-704	222	6	bioavailability	bioavailability	NOUN
admet-704	222	7	:	:	PUNCT
admet-704	222	8	an	an	DET
admet-704	222	9	industrial	industrial	ADJ
admet-704	222	10	perspective	perspective	NOUN
admet-704	222	11	.	.	PUNCT
admet-704	223	1	expert	expert	NOUN
admet-704	223	2	opin	opin	NOUN
admet-704	223	3	.	.	PUNCT
admet-704	224	1	drug	drug	NOUN
admet-704	224	2	metab	metab	NOUN
admet-704	224	3	.	.	PUNCT
admet-704	225	1	toxicol	toxicol	PROPN
admet-704	225	2	.	.	PROPN
admet-704	225	3	2	2	NUM
admet-704	225	4	(	(	PUNCT
admet-704	225	5	2006	2006	NUM
admet-704	225	6	)	)	PUNCT
admet-704	225	7	591	591	NUM
admet-704	225	8	-	-	SYM
admet-704	225	9	608	608	NUM
admet-704	225	10	.	.	PUNCT
admet-704	226	1	[	[	X
admet-704	226	2	10	10	NUM
admet-704	226	3	]	]	X
admet-704	226	4	s.	s.	PROPN
admet-704	226	5	stegemann	stegemann	PROPN
admet-704	226	6	,	,	PUNCT
admet-704	226	7	f.	f.	PROPN
admet-704	226	8	leveiller	leveiller	PROPN
admet-704	226	9	,	,	PUNCT
admet-704	226	10	d.	d.	PROPN
admet-704	226	11	franchi	franchi	PROPN
admet-704	226	12	,	,	PUNCT
admet-704	226	13	h.	h.	PROPN
admet-704	226	14	de	de	PROPN
admet-704	226	15	jong	jong	PROPN
admet-704	226	16	,	,	PUNCT
admet-704	226	17	h.	h.	PROPN
admet-704	226	18	linden	linden	PROPN
admet-704	226	19	.	.	PUNCT
admet-704	227	1	when	when	SCONJ
admet-704	227	2	poor	poor	ADJ
admet-704	227	3	solubility	solubility	NOUN
admet-704	227	4	becomes	become	VERB
admet-704	227	5	an	an	DET
admet-704	227	6	issue	issue	NOUN
admet-704	227	7	:	:	PUNCT
admet-704	227	8	from	from	ADP
admet-704	227	9	early	early	ADJ
admet-704	227	10	stage	stage	NOUN
admet-704	227	11	to	to	ADP
admet-704	227	12	proof	proof	NOUN
admet-704	227	13	of	of	ADP
admet-704	227	14	concept	concept	NOUN
admet-704	227	15	.	.	PUNCT
admet-704	228	1	eur	eur	PROPN
admet-704	228	2	.	.	PUNCT
admet-704	229	1	j.	j.	PROPN
admet-704	229	2	pharm	pharm	PROPN
admet-704	229	3	.	.	PUNCT
admet-704	230	1	sci	sci	PROPN
admet-704	230	2	.	.	PROPN
admet-704	231	1	31	31	NUM
admet-704	232	1	(	(	PUNCT
admet-704	232	2	2007	2007	NUM
admet-704	232	3	)	)	PUNCT
admet-704	232	4	249	249	NUM
admet-704	232	5	-	-	SYM
admet-704	232	6	261	261	NUM
admet-704	232	7	.	.	PUNCT
admet-704	233	1	admet	admet	PROPN
admet-704	233	2	&	&	CCONJ
admet-704	233	3	dmpk	dmpk	PROPN
admet-704	233	4	7(3	7(3	NUM
admet-704	233	5	)	)	PUNCT
admet-704	233	6	(	(	PUNCT
admet-704	233	7	2019	2019	NUM
admet-704	233	8	)	)	PUNCT
admet-704	233	9	183	183	NUM
admet-704	233	10	-	-	SYM
admet-704	233	11	195	195	NUM
admet-704	233	12	harmonizing	harmonize	VERB
admet-704	233	13	solubility	solubility	NOUN
admet-704	233	14	measurement	measurement	NOUN
admet-704	233	15	to	to	PART
admet-704	233	16	lower	lower	VERB
admet-704	233	17	inter	inter	ADJ
admet-704	233	18	-	-	ADJ
admet-704	233	19	laboratory	laboratory	ADJ
admet-704	233	20	variance	variance	NOUN
admet-704	233	21	doi	doi	NOUN
admet-704	233	22	:	:	PUNCT
admet-704	233	23	10.5599	10.5599	NUM
admet-704	233	24	/	/	SYM
admet-704	233	25	admet.704	admet.704	NOUN
admet-704	233	26	193	193	NUM
admet-704	234	1	[	[	SYM
admet-704	234	2	11	11	NUM
admet-704	234	3	]	]	PUNCT
admet-704	234	4	p.	p.	NOUN
admet-704	234	5	van	van	PROPN
admet-704	234	6	hoogevest	hoogevest	PROPN
admet-704	235	1	,	,	PUNCT
admet-704	235	2	x.	x.	PROPN
admet-704	235	3	liu	liu	PROPN
admet-704	235	4	,	,	PUNCT
admet-704	235	5	a.	a.	PROPN
admet-704	235	6	fahr	fahr	PROPN
admet-704	235	7	.	.	PUNCT
admet-704	235	8	drug	drug	NOUN
admet-704	235	9	delivery	delivery	NOUN
admet-704	235	10	strategies	strategy	NOUN
admet-704	235	11	for	for	ADP
admet-704	235	12	poorly	poorly	ADV
admet-704	235	13	water	water	NOUN
admet-704	235	14	-	-	PUNCT
admet-704	235	15	soluble	soluble	ADJ
admet-704	235	16	drugs	drug	NOUN
admet-704	235	17	:	:	PUNCT
admet-704	235	18	the	the	DET
admet-704	235	19	industrial	industrial	ADJ
admet-704	235	20	perspective	perspective	NOUN
admet-704	235	21	.	.	PUNCT
admet-704	236	1	expert	expert	NOUN
admet-704	236	2	opin	opin	NOUN
admet-704	236	3	drug	drug	NOUN
admet-704	236	4	deliv	deliv	VERB
admet-704	236	5	8	8	NUM
admet-704	236	6	(	(	PUNCT
admet-704	236	7	2011	2011	NUM
admet-704	236	8	)	)	PUNCT
admet-704	236	9	1481	1481	NUM
admet-704	236	10	-	-	SYM
admet-704	236	11	1500	1500	NUM
admet-704	236	12	.	.	PUNCT
admet-704	237	1	[	[	X
admet-704	237	2	12	12	NUM
admet-704	237	3	]	]	PUNCT
admet-704	237	4	k.	k.	PROPN
admet-704	237	5	sugano	sugano	PROPN
admet-704	237	6	,	,	PUNCT
admet-704	237	7	a.	a.	PROPN
admet-704	237	8	okazaki	okazaki	PROPN
admet-704	237	9	,	,	PUNCT
admet-704	237	10	s.	s.	PROPN
admet-704	237	11	sugimoto	sugimoto	PROPN
admet-704	237	12	,	,	PUNCT
admet-704	237	13	s.	s.	PROPN
admet-704	237	14	tavornvipas	tavornvipas	PROPN
admet-704	237	15	,	,	PUNCT
admet-704	237	16	a.	a.	NOUN
admet-704	237	17	omura	omura	PROPN
admet-704	237	18	.	.	PUNCT
admet-704	238	1	solubility	solubility	NOUN
admet-704	238	2	and	and	CCONJ
admet-704	238	3	dissolution	dissolution	NOUN
admet-704	238	4	profile	profile	NOUN
admet-704	238	5	assessment	assessment	NOUN
admet-704	238	6	in	in	ADP
admet-704	238	7	drug	drug	NOUN
admet-704	238	8	discovery	discovery	NOUN
admet-704	238	9	.	.	PUNCT
admet-704	239	1	drug	drug	NOUN
admet-704	239	2	metab	metab	PROPN
admet-704	239	3	.	.	PUNCT
admet-704	240	1	pharmacokinet	pharmacokinet	NOUN
admet-704	240	2	.	.	PUNCT
admet-704	241	1	22	22	NUM
admet-704	241	2	(	(	PUNCT
admet-704	241	3	2007	2007	NUM
admet-704	241	4	)	)	PUNCT
admet-704	241	5	225	225	NUM
admet-704	241	6	-	-	SYM
admet-704	241	7	254	254	NUM
admet-704	241	8	.	.	PUNCT
admet-704	242	1	[	[	X
admet-704	242	2	13	13	NUM
admet-704	242	3	]	]	X
admet-704	242	4	j.	j.	PROPN
admet-704	242	5	alsenz	alsenz	PROPN
admet-704	242	6	,	,	PUNCT
admet-704	242	7	m.	m.	PROPN
admet-704	242	8	kansy	kansy	PROPN
admet-704	242	9	.	.	PUNCT
admet-704	243	1	high	high	ADJ
admet-704	243	2	throughput	throughput	NOUN
admet-704	243	3	solubility	solubility	NOUN
admet-704	243	4	measurement	measurement	NOUN
admet-704	243	5	in	in	ADP
admet-704	243	6	drug	drug	NOUN
admet-704	243	7	discovery	discovery	NOUN
admet-704	243	8	and	and	CCONJ
admet-704	243	9	development	development	NOUN
admet-704	243	10	.	.	PUNCT
admet-704	244	1	adv	adv	PROPN
admet-704	244	2	drug	drug	PROPN
admet-704	244	3	deliv	deliv	NOUN
admet-704	244	4	rev	rev	VERB
admet-704	244	5	59	59	NUM
admet-704	244	6	(	(	PUNCT
admet-704	244	7	2007	2007	NUM
admet-704	244	8	)	)	PUNCT
admet-704	244	9	546	546	NUM
admet-704	244	10	-	-	SYM
admet-704	244	11	567	567	NUM
admet-704	244	12	.	.	PUNCT
admet-704	245	1	[	[	X
admet-704	245	2	14	14	NUM
admet-704	245	3	]	]	X
admet-704	245	4	l.	l.	PROPN
admet-704	245	5	di	di	PROPN
admet-704	245	6	,	,	PUNCT
admet-704	245	7	p.	p.	NOUN
admet-704	245	8	v.	v.	ADP
admet-704	245	9	fish	fish	NOUN
admet-704	245	10	,	,	PUNCT
admet-704	245	11	t.	t.	PROPN
admet-704	245	12	mano	mano	PROPN
admet-704	245	13	.	.	PUNCT
admet-704	246	1	bridging	bridging	NOUN
admet-704	246	2	solubility	solubility	NOUN
admet-704	246	3	between	between	ADP
admet-704	246	4	drug	drug	NOUN
admet-704	246	5	discovery	discovery	NOUN
admet-704	246	6	and	and	CCONJ
admet-704	246	7	development	development	NOUN
admet-704	246	8	.	.	PUNCT
admet-704	247	1	drug	drug	NOUN
admet-704	247	2	discov	discov	PROPN
admet-704	247	3	today	today	NOUN
admet-704	247	4	17	17	NUM
admet-704	247	5	(	(	PUNCT
admet-704	247	6	2012	2012	NUM
admet-704	247	7	)	)	PUNCT
admet-704	247	8	486	486	NUM
admet-704	247	9	-	-	SYM
admet-704	247	10	495	495	NUM
admet-704	247	11	.	.	PUNCT
admet-704	248	1	[	[	X
admet-704	248	2	15	15	NUM
admet-704	248	3	]	]	X
admet-704	248	4	a.	a.	NOUN
admet-704	248	5	konczol	konczol	PROPN
admet-704	248	6	,	,	PUNCT
admet-704	248	7	g.	g.	PROPN
admet-704	248	8	dargo	dargo	PROPN
admet-704	248	9	.	.	PUNCT
admet-704	249	1	brief	brief	ADJ
admet-704	249	2	overview	overview	NOUN
admet-704	249	3	of	of	ADP
admet-704	249	4	solubility	solubility	NOUN
admet-704	249	5	methods	method	NOUN
admet-704	249	6	:	:	PUNCT
admet-704	249	7	recent	recent	ADJ
admet-704	249	8	trends	trend	NOUN
admet-704	249	9	in	in	ADP
admet-704	249	10	equilibrium	equilibrium	NOUN
admet-704	249	11	solubility	solubility	NOUN
admet-704	249	12	measurement	measurement	NOUN
admet-704	249	13	and	and	CCONJ
admet-704	249	14	predictive	predictive	ADJ
admet-704	249	15	models	model	NOUN
admet-704	249	16	.	.	PUNCT
admet-704	250	1	drug	drug	NOUN
admet-704	250	2	discovery	discovery	PROPN
admet-704	250	3	today	today	NOUN
admet-704	250	4	.	.	PUNCT
admet-704	251	1	technologies	technology	NOUN
admet-704	251	2	27	27	NUM
admet-704	251	3	(	(	PUNCT
admet-704	251	4	2018	2018	NUM
admet-704	251	5	)	)	PUNCT
admet-704	251	6	3	3	NUM
admet-704	251	7	-	-	SYM
admet-704	251	8	10	10	NUM
admet-704	251	9	.	.	PUNCT
admet-704	252	1	[	[	X
admet-704	252	2	16	16	NUM
admet-704	252	3	]	]	X
admet-704	252	4	l.	l.	PROPN
admet-704	252	5	di	di	PROPN
admet-704	252	6	,	,	PUNCT
admet-704	252	7	e.	e.	PROPN
admet-704	252	8	h.	h.	PROPN
admet-704	252	9	kerns	kerns	PROPN
admet-704	252	10	,	,	PUNCT
admet-704	252	11	g.	g.	PROPN
admet-704	252	12	t.	t.	PROPN
admet-704	252	13	carter	carter	PROPN
admet-704	252	14	.	.	PUNCT
admet-704	252	15	drug	drug	NOUN
admet-704	252	16	-	-	PUNCT
admet-704	252	17	like	like	ADJ
admet-704	252	18	property	property	NOUN
admet-704	252	19	concepts	concept	NOUN
admet-704	252	20	in	in	ADP
admet-704	252	21	pharmaceutical	pharmaceutical	ADJ
admet-704	252	22	design	design	NOUN
admet-704	252	23	.	.	PUNCT
admet-704	253	1	curr	curr	PROPN
admet-704	253	2	.	.	PUNCT
admet-704	254	1	pharm	pharm	PROPN
admet-704	254	2	.	.	PUNCT
admet-704	255	1	des	des	PROPN
admet-704	255	2	.	.	PROPN
admet-704	255	3	15	15	NUM
admet-704	255	4	(	(	PUNCT
admet-704	255	5	2009	2009	NUM
admet-704	255	6	)	)	PUNCT
admet-704	255	7	2184	2184	NUM
admet-704	255	8	-	-	SYM
admet-704	255	9	2194	2194	NUM
admet-704	255	10	.	.	PUNCT
admet-704	256	1	[	[	X
admet-704	256	2	17	17	NUM
admet-704	256	3	]	]	X
admet-704	256	4	c.	c.	PROPN
admet-704	256	5	a.	a.	PROPN
admet-704	256	6	lipinski	lipinski	PROPN
admet-704	256	7	,	,	PUNCT
admet-704	256	8	f.	f.	PROPN
admet-704	256	9	lombardo	lombardo	PROPN
admet-704	256	10	,	,	PUNCT
admet-704	256	11	b.	b.	PROPN
admet-704	256	12	w.	w.	PROPN
admet-704	256	13	dominy	dominy	PROPN
admet-704	256	14	,	,	PUNCT
admet-704	256	15	p.	p.	PROPN
admet-704	256	16	j.	j.	PROPN
admet-704	256	17	feeney	feeney	PROPN
admet-704	256	18	.	.	PUNCT
admet-704	257	1	experimental	experimental	ADJ
admet-704	257	2	and	and	CCONJ
admet-704	257	3	computational	computational	ADJ
admet-704	257	4	approaches	approach	NOUN
admet-704	257	5	to	to	PART
admet-704	257	6	estimate	estimate	VERB
admet-704	257	7	solubility	solubility	NOUN
admet-704	257	8	and	and	CCONJ
admet-704	257	9	permeability	permeability	NOUN
admet-704	257	10	in	in	ADP
admet-704	257	11	drug	drug	NOUN
admet-704	257	12	discovery	discovery	NOUN
admet-704	257	13	and	and	CCONJ
admet-704	257	14	development	development	NOUN
admet-704	257	15	settings	setting	NOUN
admet-704	257	16	.	.	PUNCT
admet-704	258	1	advanced	advanced	ADJ
admet-704	258	2	drug	drug	NOUN
admet-704	258	3	delivery	delivery	NOUN
admet-704	258	4	reviews	review	VERB
admet-704	258	5	64	64	NUM
admet-704	258	6	(	(	PUNCT
admet-704	258	7	2012	2012	NUM
admet-704	258	8	)	)	PUNCT
admet-704	258	9	4	4	NUM
admet-704	258	10	-	-	SYM
admet-704	258	11	17	17	NUM
admet-704	258	12	.	.	PUNCT
admet-704	259	1	[	[	X
admet-704	259	2	18	18	NUM
admet-704	259	3	]	]	X
admet-704	259	4	g.	g.	PROPN
admet-704	259	5	papadatos	papadato	NOUN
admet-704	259	6	,	,	PUNCT
admet-704	259	7	m.	m.	NOUN
admet-704	259	8	alkarouri	alkarouri	PROPN
admet-704	259	9	,	,	PUNCT
admet-704	259	10	v.	v.	ADP
admet-704	259	11	j.	j.	PROPN
admet-704	259	12	gillet	gillet	PROPN
admet-704	259	13	,	,	PUNCT
admet-704	259	14	p.	p.	NOUN
admet-704	259	15	willett	willett	NOUN
admet-704	259	16	,	,	PUNCT
admet-704	259	17	v.	v.	ADP
admet-704	259	18	kadirkamanathan	kadirkamanathan	PROPN
admet-704	259	19	,	,	PUNCT
admet-704	259	20	c.	c.	PROPN
admet-704	259	21	n.	n.	PROPN
admet-704	259	22	luscombe	luscombe	PROPN
admet-704	259	23	,	,	PUNCT
admet-704	259	24	g.	g.	PROPN
admet-704	259	25	bravi	bravi	PROPN
admet-704	259	26	,	,	PUNCT
admet-704	259	27	n.	n.	PROPN
admet-704	259	28	j.	j.	PROPN
admet-704	259	29	richmond	richmond	PROPN
admet-704	259	30	,	,	PUNCT
admet-704	259	31	s.	s.	PROPN
admet-704	259	32	d.	d.	PROPN
admet-704	259	33	pickett	pickett	PROPN
admet-704	259	34	,	,	PUNCT
admet-704	259	35	j.	j.	PROPN
admet-704	259	36	hussain	hussain	PROPN
admet-704	259	37	.	.	PUNCT
admet-704	260	1	lead	lead	VERB
admet-704	260	2	optimization	optimization	NOUN
admet-704	260	3	using	use	VERB
admet-704	260	4	matched	match	VERB
admet-704	260	5	molecular	molecular	ADJ
admet-704	260	6	pairs	pair	NOUN
admet-704	260	7	:	:	PUNCT
admet-704	260	8	inclusion	inclusion	NOUN
admet-704	260	9	of	of	ADP
admet-704	260	10	contextual	contextual	ADJ
admet-704	260	11	information	information	NOUN
admet-704	260	12	for	for	ADP
admet-704	260	13	enhanced	enhanced	ADJ
admet-704	260	14	prediction	prediction	NOUN
admet-704	260	15	of	of	ADP
admet-704	260	16	herg	herg	PROPN
admet-704	260	17	inhibition	inhibition	NOUN
admet-704	260	18	,	,	PUNCT
admet-704	260	19	solubility	solubility	NOUN
admet-704	260	20	,	,	PUNCT
admet-704	260	21	and	and	CCONJ
admet-704	260	22	lipophilicity	lipophilicity	NOUN
admet-704	260	23	.	.	PUNCT
admet-704	261	1	j.	j.	PROPN
admet-704	261	2	chem	chem	PROPN
admet-704	261	3	.	.	PUNCT
admet-704	262	1	inf	inf	PROPN
admet-704	262	2	.	.	PROPN
admet-704	262	3	model	model	PROPN
admet-704	262	4	.	.	PUNCT
admet-704	263	1	50	50	NUM
admet-704	263	2	(	(	PUNCT
admet-704	263	3	2010	2010	NUM
admet-704	263	4	)	)	PUNCT
admet-704	263	5	1872	1872	NUM
admet-704	263	6	-	-	SYM
admet-704	263	7	1886	1886	NUM
admet-704	263	8	.	.	PUNCT
admet-704	264	1	[	[	X
admet-704	264	2	19	19	NUM
admet-704	264	3	]	]	X
admet-704	264	4	c.	c.	PROPN
admet-704	264	5	le	le	PROPN
admet-704	264	6	manach	manach	ADV
admet-704	264	7	,	,	PUNCT
admet-704	264	8	a.	a.	NOUN
admet-704	264	9	t.	t.	PROPN
admet-704	264	10	nchinda	nchinda	PROPN
admet-704	264	11	,	,	PUNCT
admet-704	264	12	t.	t.	PROPN
admet-704	264	13	paquet	paquet	PROPN
admet-704	264	14	,	,	PUNCT
admet-704	264	15	d.	d.	PROPN
admet-704	264	16	gonzalez	gonzalez	PROPN
admet-704	264	17	cabrera	cabrera	PROPN
admet-704	264	18	,	,	PUNCT
admet-704	264	19	y.	y.	PROPN
admet-704	264	20	younis	younis	PROPN
admet-704	264	21	,	,	PUNCT
admet-704	264	22	z.	z.	PROPN
admet-704	264	23	han	han	PROPN
admet-704	264	24	,	,	PUNCT
admet-704	264	25	s.	s.	PROPN
admet-704	264	26	bashyam	bashyam	PROPN
admet-704	264	27	,	,	PUNCT
admet-704	264	28	m.	m.	NOUN
admet-704	264	29	zabiulla	zabiulla	PROPN
admet-704	264	30	,	,	PUNCT
admet-704	264	31	d.	d.	PROPN
admet-704	264	32	taylor	taylor	PROPN
admet-704	264	33	,	,	PUNCT
admet-704	264	34	n.	n.	PROPN
admet-704	264	35	lawrence	lawrence	PROPN
admet-704	264	36	,	,	PUNCT
admet-704	264	37	k.	k.	PROPN
admet-704	264	38	l.	l.	PROPN
admet-704	264	39	white	white	PROPN
admet-704	264	40	,	,	PUNCT
admet-704	264	41	s.	s.	PROPN
admet-704	264	42	a.	a.	PROPN
admet-704	264	43	charman	charman	PROPN
admet-704	264	44	,	,	PUNCT
admet-704	264	45	d.	d.	PROPN
admet-704	264	46	waterson	waterson	PROPN
admet-704	264	47	,	,	PUNCT
admet-704	264	48	m.	m.	PROPN
admet-704	264	49	j.	j.	PROPN
admet-704	264	50	witty	witty	PROPN
admet-704	264	51	,	,	PUNCT
admet-704	264	52	s.	s.	PROPN
admet-704	264	53	wittlin	wittlin	PROPN
admet-704	264	54	,	,	PUNCT
admet-704	264	55	m.	m.	PROPN
admet-704	264	56	e.	e.	PROPN
admet-704	264	57	botha	botha	PROPN
admet-704	264	58	,	,	PUNCT
admet-704	264	59	s.	s.	PROPN
admet-704	264	60	h.	h.	PROPN
admet-704	264	61	nondaba	nondaba	PROPN
admet-704	264	62	,	,	PUNCT
admet-704	264	63	j.	j.	PROPN
admet-704	264	64	reader	reader	PROPN
admet-704	264	65	,	,	PUNCT
admet-704	264	66	l.	l.	PROPN
admet-704	264	67	m.	m.	PROPN
admet-704	264	68	birkholtz	birkholtz	PROPN
admet-704	264	69	,	,	PUNCT
admet-704	264	70	m.	m.	PROPN
admet-704	264	71	b.	b.	PROPN
admet-704	264	72	jimenez	jimenez	PROPN
admet-704	264	73	-	-	PUNCT
admet-704	264	74	diaz	diaz	PROPN
admet-704	264	75	,	,	PUNCT
admet-704	264	76	m.	m.	NOUN
admet-704	264	77	s.	s.	PROPN
admet-704	264	78	martinez	martinez	PROPN
admet-704	264	79	,	,	PUNCT
admet-704	264	80	s.	s.	PROPN
admet-704	264	81	ferrer	ferrer	PROPN
admet-704	264	82	,	,	PUNCT
admet-704	264	83	i.	i.	PROPN
admet-704	264	84	angulo	angulo	PROPN
admet-704	264	85	-	-	PUNCT
admet-704	264	86	barturen	barturen	PROPN
admet-704	264	87	,	,	PUNCT
admet-704	264	88	s.	s.	PROPN
admet-704	264	89	meister	meister	PROPN
admet-704	264	90	,	,	PUNCT
admet-704	264	91	y.	y.	PROPN
admet-704	264	92	antonova	antonova	PROPN
admet-704	264	93	-	-	PUNCT
admet-704	264	94	koch	koch	PROPN
admet-704	264	95	,	,	PUNCT
admet-704	264	96	e.	e.	PROPN
admet-704	264	97	a.	a.	PROPN
admet-704	264	98	winzeler	winzeler	PROPN
admet-704	264	99	,	,	PUNCT
admet-704	264	100	l.	l.	PROPN
admet-704	264	101	j.	j.	PROPN
admet-704	264	102	street	street	PROPN
admet-704	264	103	,	,	PUNCT
admet-704	264	104	k.	k.	PROPN
admet-704	264	105	chibale	chibale	PROPN
admet-704	264	106	.	.	PUNCT
admet-704	265	1	identification	identification	NOUN
admet-704	265	2	of	of	ADP
admet-704	265	3	a	a	DET
admet-704	265	4	potential	potential	ADJ
admet-704	265	5	antimalarial	antimalarial	ADJ
admet-704	265	6	drug	drug	NOUN
admet-704	265	7	candidate	candidate	NOUN
admet-704	265	8	from	from	ADP
admet-704	265	9	a	a	DET
admet-704	265	10	series	series	NOUN
admet-704	265	11	of	of	ADP
admet-704	265	12	2	2	NUM
admet-704	265	13	-	-	PUNCT
admet-704	265	14	aminopyrazines	aminopyrazine	NOUN
admet-704	265	15	by	by	ADP
admet-704	265	16	optimization	optimization	NOUN
admet-704	265	17	of	of	ADP
admet-704	265	18	aqueous	aqueous	ADJ
admet-704	265	19	solubility	solubility	NOUN
admet-704	265	20	and	and	CCONJ
admet-704	265	21	potency	potency	NOUN
admet-704	265	22	across	across	ADP
admet-704	265	23	the	the	DET
admet-704	265	24	parasite	parasite	ADJ
admet-704	265	25	life	life	NOUN
admet-704	265	26	cycle	cycle	NOUN
admet-704	265	27	.	.	PUNCT
admet-704	266	1	j.	j.	PROPN
admet-704	266	2	med	med	PROPN
admet-704	266	3	.	.	PROPN
admet-704	266	4	chem	chem	PROPN
admet-704	266	5	.	.	PUNCT
admet-704	267	1	59	59	NUM
admet-704	267	2	(	(	PUNCT
admet-704	267	3	2016	2016	NUM
admet-704	267	4	)	)	PUNCT
admet-704	267	5	9890	9890	NUM
admet-704	267	6	-	-	SYM
admet-704	267	7	9905	9905	NUM
admet-704	267	8	.	.	PUNCT
admet-704	268	1	[	[	X
admet-704	268	2	20	20	NUM
admet-704	268	3	]	]	PUNCT
admet-704	268	4	r.	r.	PROPN
admet-704	268	5	takano	takano	PROPN
admet-704	268	6	,	,	PUNCT
admet-704	268	7	k.	k.	PROPN
admet-704	268	8	furumoto	furumoto	PROPN
admet-704	268	9	,	,	PUNCT
admet-704	268	10	k.	k.	PROPN
admet-704	268	11	shiraki	shiraki	PROPN
admet-704	268	12	,	,	PUNCT
admet-704	268	13	n.	n.	NOUN
admet-704	268	14	takata	takata	NOUN
admet-704	268	15	,	,	PUNCT
admet-704	268	16	y.	y.	PROPN
admet-704	268	17	hayashi	hayashi	PROPN
admet-704	268	18	,	,	PUNCT
admet-704	268	19	y.	y.	PROPN
admet-704	268	20	aso	aso	PROPN
admet-704	268	21	,	,	PUNCT
admet-704	268	22	s.	s.	PROPN
admet-704	268	23	yamashita	yamashita	PROPN
admet-704	268	24	.	.	PUNCT
admet-704	269	1	rate	rate	NOUN
admet-704	269	2	-	-	PUNCT
admet-704	269	3	limiting	limit	VERB
admet-704	269	4	steps	step	NOUN
admet-704	269	5	of	of	ADP
admet-704	269	6	oral	oral	ADJ
admet-704	269	7	absorption	absorption	NOUN
admet-704	269	8	for	for	ADP
admet-704	269	9	poorly	poorly	ADV
admet-704	269	10	water	water	NOUN
admet-704	269	11	-	-	PUNCT
admet-704	269	12	soluble	soluble	ADJ
admet-704	269	13	drugs	drug	NOUN
admet-704	269	14	in	in	ADP
admet-704	269	15	dogs	dog	NOUN
admet-704	269	16	;	;	PUNCT
admet-704	269	17	prediction	prediction	NOUN
admet-704	269	18	from	from	ADP
admet-704	269	19	a	a	DET
admet-704	269	20	miniscale	miniscale	NOUN
admet-704	269	21	dissolution	dissolution	NOUN
admet-704	269	22	test	test	NOUN
admet-704	269	23	and	and	CCONJ
admet-704	269	24	a	a	DET
admet-704	269	25	physiologically	physiologically	ADV
admet-704	269	26	-	-	PUNCT
admet-704	269	27	based	base	VERB
admet-704	269	28	computer	computer	NOUN
admet-704	269	29	simulation	simulation	NOUN
admet-704	269	30	.	.	PUNCT
admet-704	270	1	pharm	pharm	PROPN
admet-704	270	2	.	.	PUNCT
admet-704	271	1	res	re	NOUN
admet-704	271	2	.	.	PROPN
admet-704	272	1	25	25	NUM
admet-704	272	2	(	(	PUNCT
admet-704	272	3	2008	2008	NUM
admet-704	272	4	)	)	PUNCT
admet-704	272	5	2334	2334	NUM
admet-704	272	6	-	-	SYM
admet-704	272	7	2344	2344	NUM
admet-704	272	8	.	.	PUNCT
admet-704	273	1	[	[	X
admet-704	273	2	21	21	NUM
admet-704	273	3	]	]	PUNCT
admet-704	273	4	k.	k.	PROPN
admet-704	273	5	sugano	sugano	PROPN
admet-704	273	6	.	.	PUNCT
admet-704	274	1	fraction	fraction	NOUN
admet-704	274	2	of	of	ADP
admet-704	274	3	a	a	DET
admet-704	274	4	dose	dose	NOUN
admet-704	274	5	absorbed	absorb	VERB
admet-704	274	6	estimation	estimation	NOUN
admet-704	274	7	for	for	ADP
admet-704	274	8	structurally	structurally	ADV
admet-704	274	9	diverse	diverse	ADJ
admet-704	274	10	low	low	ADJ
admet-704	274	11	solubility	solubility	NOUN
admet-704	274	12	compounds	compound	NOUN
admet-704	274	13	.	.	PUNCT
admet-704	275	1	int	int	NOUN
admet-704	275	2	.	.	PUNCT
admet-704	276	1	j.	j.	PROPN
admet-704	276	2	pharm	pharm	PROPN
admet-704	276	3	.	.	PUNCT
admet-704	277	1	405	405	NUM
admet-704	277	2	(	(	PUNCT
admet-704	277	3	2011	2011	NUM
admet-704	277	4	)	)	PUNCT
admet-704	277	5	79	79	NUM
admet-704	277	6	-	-	SYM
admet-704	277	7	89	89	NUM
admet-704	277	8	.	.	PUNCT
admet-704	278	1	[	[	X
admet-704	278	2	22	22	NUM
admet-704	278	3	]	]	X
admet-704	278	4	n.	n.	NOUN
admet-704	278	5	matsumura	matsumura	ADV
admet-704	278	6	,	,	PUNCT
admet-704	278	7	y.	y.	PROPN
admet-704	278	8	yamaura	yamaura	PROPN
admet-704	278	9	,	,	PUNCT
admet-704	278	10	j.	j.	PROPN
admet-704	278	11	katagi	katagi	PROPN
admet-704	278	12	,	,	PUNCT
admet-704	278	13	s.	s.	PROPN
admet-704	278	14	ono	ono	PROPN
admet-704	278	15	,	,	PUNCT
admet-704	278	16	s.	s.	PROPN
admet-704	278	17	kim	kim	PROPN
admet-704	278	18	,	,	PUNCT
admet-704	278	19	s.	s.	PROPN
admet-704	278	20	yamashita	yamashita	PROPN
admet-704	278	21	,	,	PUNCT
admet-704	278	22	k.	k.	PROPN
admet-704	278	23	sugano	sugano	PROPN
admet-704	278	24	.	.	PUNCT
admet-704	279	1	evaluation	evaluation	NOUN
admet-704	279	2	of	of	ADP
admet-704	279	3	using	use	VERB
admet-704	279	4	dogs	dog	NOUN
admet-704	279	5	to	to	PART
admet-704	279	6	predict	predict	VERB
admet-704	279	7	fraction	fraction	NOUN
admet-704	279	8	of	of	ADP
admet-704	279	9	oral	oral	ADJ
admet-704	279	10	dose	dose	NOUN
admet-704	279	11	absorbed	absorb	VERB
admet-704	279	12	in	in	ADP
admet-704	279	13	humans	human	NOUN
admet-704	279	14	for	for	ADP
admet-704	279	15	poorly	poorly	ADV
admet-704	279	16	water	water	NOUN
admet-704	279	17	-	-	PUNCT
admet-704	279	18	soluble	soluble	ADJ
admet-704	279	19	drugs	drug	NOUN
admet-704	279	20	.	.	PUNCT
admet-704	280	1	j.	j.	PROPN
admet-704	280	2	pharm	pharm	PROPN
admet-704	280	3	.	.	PUNCT
admet-704	281	1	sci	sci	PROPN
admet-704	281	2	.	.	PROPN
admet-704	282	1	107	107	NUM
admet-704	282	2	(	(	PUNCT
admet-704	282	3	2018	2018	NUM
admet-704	282	4	)	)	PUNCT
admet-704	282	5	2489	2489	NUM
admet-704	282	6	-	-	SYM
admet-704	282	7	2496	2496	NUM
admet-704	282	8	.	.	PUNCT
admet-704	283	1	[	[	X
admet-704	283	2	23	23	NUM
admet-704	283	3	]	]	X
admet-704	283	4	c.	c.	PROPN
admet-704	283	5	a.	a.	PROPN
admet-704	283	6	bergstrom	bergstrom	PROPN
admet-704	283	7	,	,	PUNCT
admet-704	283	8	r.	r.	PROPN
admet-704	283	9	holm	holm	PROPN
admet-704	283	10	,	,	PUNCT
admet-704	283	11	s.	s.	PROPN
admet-704	283	12	a.	a.	PROPN
admet-704	283	13	jorgensen	jorgensen	PROPN
admet-704	283	14	,	,	PUNCT
admet-704	283	15	s.	s.	PROPN
admet-704	283	16	b.	b.	PROPN
admet-704	283	17	andersson	andersson	PROPN
admet-704	283	18	,	,	PUNCT
admet-704	283	19	p.	p.	PROPN
admet-704	283	20	artursson	artursson	PROPN
admet-704	283	21	,	,	PUNCT
admet-704	283	22	s.	s.	PROPN
admet-704	283	23	beato	beato	PROPN
admet-704	283	24	,	,	PUNCT
admet-704	283	25	a.	a.	PROPN
admet-704	283	26	borde	borde	PROPN
admet-704	283	27	,	,	PUNCT
admet-704	283	28	k.	k.	PROPN
admet-704	283	29	box	box	PROPN
admet-704	283	30	,	,	PUNCT
admet-704	283	31	m.	m.	NOUN
admet-704	283	32	brewster	brewster	NOUN
admet-704	283	33	,	,	PUNCT
admet-704	283	34	j.	j.	PROPN
admet-704	283	35	dressman	dressman	PROPN
admet-704	283	36	,	,	PUNCT
admet-704	283	37	k.	k.	PROPN
admet-704	283	38	i.	i.	PROPN
admet-704	283	39	feng	feng	PROPN
admet-704	283	40	,	,	PUNCT
admet-704	283	41	g.	g.	PROPN
admet-704	283	42	halbert	halbert	PROPN
admet-704	283	43	,	,	PUNCT
admet-704	283	44	e.	e.	PROPN
admet-704	283	45	kostewicz	kostewicz	PROPN
admet-704	283	46	,	,	PUNCT
admet-704	283	47	m.	m.	NOUN
admet-704	283	48	mcallister	mcallister	PROPN
admet-704	283	49	,	,	PUNCT
admet-704	283	50	u.	u.	PROPN
admet-704	283	51	muenster	muenster	PROPN
admet-704	283	52	,	,	PUNCT
admet-704	283	53	j.	j.	PROPN
admet-704	283	54	thinnes	thinnes	PROPN
admet-704	283	55	,	,	PUNCT
admet-704	283	56	r.	r.	PROPN
admet-704	283	57	taylor	taylor	PROPN
admet-704	283	58	,	,	PUNCT
admet-704	283	59	a.	a.	NOUN
admet-704	283	60	mullertz	mullertz	NOUN
admet-704	283	61	.	.	PUNCT
admet-704	284	1	early	early	ADJ
admet-704	284	2	pharmaceutical	pharmaceutical	NOUN
admet-704	284	3	profiling	profiling	NOUN
admet-704	284	4	to	to	PART
admet-704	284	5	predict	predict	VERB
admet-704	284	6	oral	oral	ADJ
admet-704	284	7	drug	drug	NOUN
admet-704	284	8	absorption	absorption	NOUN
admet-704	284	9	:	:	PUNCT
admet-704	284	10	current	current	ADJ
admet-704	284	11	status	status	NOUN
admet-704	284	12	and	and	CCONJ
admet-704	284	13	unmet	unmet	NOUN
admet-704	284	14	needs	need	NOUN
admet-704	284	15	.	.	PUNCT
admet-704	285	1	eur	eur	PROPN
admet-704	285	2	.	.	PUNCT
admet-704	286	1	j.	j.	PROPN
admet-704	286	2	pharm	pharm	PROPN
admet-704	286	3	.	.	PUNCT
admet-704	287	1	sci	sci	PROPN
admet-704	287	2	.	.	PROPN
admet-704	288	1	57	57	NUM
admet-704	288	2	(	(	PUNCT
admet-704	288	3	2014	2014	NUM
admet-704	288	4	)	)	PUNCT
admet-704	288	5	173	173	NUM
admet-704	288	6	-	-	SYM
admet-704	288	7	199	199	NUM
admet-704	288	8	.	.	PUNCT
admet-704	289	1	[	[	X
admet-704	289	2	24	24	NUM
admet-704	289	3	]	]	X
admet-704	289	4	v.	v.	CCONJ
admet-704	289	5	saxena	saxena	PROPN
admet-704	289	6	,	,	PUNCT
admet-704	289	7	r.	r.	PROPN
admet-704	289	8	panicucci	panicucci	PROPN
admet-704	289	9	,	,	PUNCT
admet-704	289	10	y.	y.	PROPN
admet-704	289	11	joshi	joshi	PROPN
admet-704	289	12	,	,	PUNCT
admet-704	289	13	s.	s.	PROPN
admet-704	289	14	garad	garad	PROPN
admet-704	289	15	.	.	PUNCT
admet-704	290	1	developability	developability	NOUN
admet-704	290	2	assessment	assessment	NOUN
admet-704	290	3	in	in	ADP
admet-704	290	4	pharmaceutical	pharmaceutical	ADJ
admet-704	290	5	industry	industry	NOUN
admet-704	290	6	:	:	PUNCT
admet-704	290	7	an	an	DET
admet-704	290	8	integrated	integrate	VERB
admet-704	290	9	group	group	NOUN
admet-704	290	10	approach	approach	NOUN
admet-704	290	11	for	for	ADP
admet-704	290	12	selecting	select	VERB
admet-704	290	13	developable	developable	ADJ
admet-704	290	14	candidates	candidate	NOUN
admet-704	290	15	.	.	PUNCT
admet-704	291	1	j.	j.	PROPN
admet-704	291	2	pharm	pharm	PROPN
admet-704	291	3	.	.	PUNCT
admet-704	292	1	sci	sci	PROPN
admet-704	292	2	.	.	PROPN
admet-704	293	1	98	98	NUM
admet-704	293	2	(	(	PUNCT
admet-704	293	3	2009	2009	NUM
admet-704	293	4	)	)	PUNCT
admet-704	293	5	1962	1962	NUM
admet-704	293	6	-	-	SYM
admet-704	293	7	1979	1979	NUM
admet-704	293	8	.	.	PUNCT
admet-704	294	1	[	[	X
admet-704	294	2	25	25	NUM
admet-704	294	3	]	]	X
admet-704	294	4	y.	y.	PROPN
admet-704	294	5	kawabata	kawabata	PROPN
admet-704	294	6	,	,	PUNCT
admet-704	294	7	k.	k.	PROPN
admet-704	294	8	wada	wada	PROPN
admet-704	294	9	,	,	PUNCT
admet-704	294	10	m.	m.	NOUN
admet-704	294	11	nakatani	nakatani	PROPN
admet-704	294	12	,	,	PUNCT
admet-704	294	13	s.	s.	PROPN
admet-704	294	14	yamada	yamada	PROPN
admet-704	294	15	,	,	PUNCT
admet-704	294	16	s.	s.	PROPN
admet-704	294	17	onoue	onoue	PROPN
admet-704	294	18	.	.	PUNCT
admet-704	295	1	formulation	formulation	NOUN
admet-704	295	2	design	design	NOUN
admet-704	295	3	for	for	ADP
admet-704	295	4	poorly	poorly	ADV
admet-704	295	5	watersoluble	watersoluble	ADJ
admet-704	295	6	drugs	drug	NOUN
admet-704	295	7	based	base	VERB
admet-704	295	8	on	on	ADP
admet-704	295	9	biopharmaceutics	biopharmaceutics	NOUN
admet-704	295	10	classification	classification	NOUN
admet-704	295	11	system	system	NOUN
admet-704	295	12	:	:	PUNCT
admet-704	295	13	basic	basic	ADJ
admet-704	295	14	approaches	approach	NOUN
admet-704	295	15	and	and	CCONJ
admet-704	295	16	practical	practical	ADJ
admet-704	295	17	applications	application	NOUN
admet-704	295	18	.	.	PUNCT
admet-704	296	1	int	int	NOUN
admet-704	296	2	.	.	PUNCT
admet-704	297	1	j.	j.	PROPN
admet-704	297	2	pharm	pharm	PROPN
admet-704	297	3	.	.	PUNCT
admet-704	298	1	420	420	NUM
admet-704	298	2	(	(	PUNCT
admet-704	298	3	2011	2011	NUM
admet-704	298	4	)	)	PUNCT
admet-704	298	5	1	1	NUM
admet-704	298	6	-	-	SYM
admet-704	298	7	10	10	NUM
admet-704	298	8	.	.	PUNCT
admet-704	299	1	[	[	X
admet-704	299	2	26	26	NUM
admet-704	299	3	]	]	PUNCT
admet-704	299	4	a.	a.	NOUN
admet-704	299	5	dahan	dahan	PROPN
admet-704	299	6	,	,	PUNCT
admet-704	299	7	a.	a.	PROPN
admet-704	299	8	beig	beig	PROPN
admet-704	299	9	,	,	PUNCT
admet-704	299	10	d.	d.	PROPN
admet-704	299	11	lindley	lindley	PROPN
admet-704	299	12	,	,	PUNCT
admet-704	299	13	j.	j.	PROPN
admet-704	299	14	m.	m.	PROPN
admet-704	299	15	miller	miller	PROPN
admet-704	299	16	.	.	PUNCT
admet-704	300	1	the	the	DET
admet-704	300	2	solubility	solubility	NOUN
admet-704	300	3	-	-	PUNCT
admet-704	300	4	permeability	permeability	NOUN
admet-704	300	5	interplay	interplay	NOUN
admet-704	300	6	and	and	CCONJ
admet-704	300	7	oral	oral	ADJ
admet-704	300	8	drug	drug	NOUN
admet-704	300	9	formulation	formulation	NOUN
admet-704	300	10	design	design	NOUN
admet-704	300	11	:	:	PUNCT
admet-704	300	12	two	two	NUM
admet-704	300	13	heads	head	NOUN
admet-704	300	14	are	be	AUX
admet-704	300	15	better	well	ADJ
admet-704	300	16	than	than	ADP
admet-704	300	17	one	one	NUM
admet-704	300	18	.	.	PUNCT
admet-704	301	1	adv	adv	PROPN
admet-704	301	2	drug	drug	PROPN
admet-704	301	3	deliv	deliv	NOUN
admet-704	301	4	rev	rev	VERB
admet-704	301	5	101	101	NUM
admet-704	301	6	(	(	PUNCT
admet-704	301	7	2016	2016	NUM
admet-704	301	8	)	)	PUNCT
admet-704	301	9	99	99	NUM
admet-704	301	10	-	-	SYM
admet-704	301	11	107	107	NUM
admet-704	301	12	.	.	PUNCT
admet-704	302	1	[	[	X
admet-704	302	2	27	27	NUM
admet-704	302	3	]	]	X
admet-704	302	4	d.	d.	PROPN
admet-704	302	5	s.	s.	PROPN
admet-704	302	6	palmer	palmer	PROPN
admet-704	302	7	,	,	PUNCT
admet-704	302	8	j.	j.	PROPN
admet-704	302	9	b.	b.	PROPN
admet-704	302	10	mitchell	mitchell	PROPN
admet-704	302	11	.	.	PUNCT
admet-704	302	12	is	be	AUX
admet-704	302	13	experimental	experimental	ADJ
admet-704	302	14	data	datum	NOUN
admet-704	302	15	quality	quality	NOUN
admet-704	302	16	the	the	DET
admet-704	302	17	limiting	limit	VERB
admet-704	302	18	factor	factor	NOUN
admet-704	302	19	in	in	ADP
admet-704	302	20	predicting	predict	VERB
admet-704	302	21	the	the	DET
admet-704	302	22	aqueous	aqueous	ADJ
admet-704	302	23	solubility	solubility	NOUN
admet-704	302	24	of	of	ADP
admet-704	302	25	druglike	druglike	ADJ
admet-704	302	26	molecules	molecule	NOUN
admet-704	302	27	?	?	PUNCT
admet-704	303	1	mol	mol	PROPN
admet-704	303	2	.	.	PUNCT
admet-704	303	3	pharm	pharm	PROPN
admet-704	303	4	.	.	PUNCT
admet-704	304	1	11	11	NUM
admet-704	304	2	(	(	PUNCT
admet-704	304	3	2014	2014	NUM
admet-704	304	4	)	)	PUNCT
admet-704	304	5	2962	2962	NUM
admet-704	304	6	-	-	SYM
admet-704	304	7	2972	2972	NUM
admet-704	304	8	.	.	PUNCT
admet-704	305	1	[	[	X
admet-704	305	2	28	28	NUM
admet-704	305	3	]	]	X
admet-704	305	4	a.	a.	NOUN
admet-704	305	5	avdeef	avdeef	PROPN
admet-704	305	6	,	,	PUNCT
admet-704	305	7	e.	e.	PROPN
admet-704	305	8	fuguet	fuguet	PROPN
admet-704	305	9	,	,	PUNCT
admet-704	305	10	a.	a.	PROPN
admet-704	305	11	llinàs	llinàs	PROPN
admet-704	305	12	,	,	PUNCT
admet-704	305	13	c.	c.	PROPN
admet-704	305	14	ràfols	ràfols	PROPN
admet-704	305	15	,	,	PUNCT
admet-704	305	16	e.	e.	PROPN
admet-704	305	17	bosch	bosch	PROPN
admet-704	305	18	,	,	PUNCT
admet-704	305	19	g.	g.	PROPN
admet-704	305	20	völgyi	völgyi	PROPN
admet-704	305	21	,	,	PUNCT
admet-704	305	22	t.	t.	NOUN
admet-704	305	23	verbić	verbić	PROPN
admet-704	305	24	,	,	PUNCT
admet-704	305	25	e.	e.	PROPN
admet-704	305	26	boldyreva	boldyreva	PROPN
admet-704	305	27	,	,	PUNCT
admet-704	305	28	k.	k.	PROPN
admet-704	305	29	takács	takács	PROPN
admet-704	305	30	-	-	PUNCT
admet-704	305	31	novák	novák	PROPN
admet-704	305	32	.	.	PUNCT
admet-704	306	1	equilibrium	equilibrium	NOUN
admet-704	306	2	solubility	solubility	NOUN
admet-704	306	3	measurement	measurement	NOUN
admet-704	306	4	of	of	ADP
admet-704	306	5	ionizable	ionizable	ADJ
admet-704	306	6	drugs	drug	NOUN
admet-704	306	7	–	–	PUNCT
admet-704	306	8	consensus	consensus	NOUN
admet-704	306	9	recommendations	recommendation	NOUN
admet-704	306	10	for	for	ADP
admet-704	306	11	improving	improve	VERB
admet-704	306	12	data	datum	NOUN
admet-704	306	13	quality	quality	NOUN
admet-704	306	14	.	.	PUNCT
admet-704	307	1	admet	admet	PROPN
admet-704	307	2	and	and	CCONJ
admet-704	307	3	dmpk	dmpk	VERB
admet-704	307	4	4	4	NUM
admet-704	307	5	(	(	PUNCT
admet-704	307	6	2016	2016	NUM
admet-704	307	7	)	)	PUNCT
admet-704	307	8	117	117	NUM
admet-704	307	9	.	.	PUNCT
admet-704	308	1	[	[	X
admet-704	308	2	29	29	NUM
admet-704	308	3	]	]	PUNCT
admet-704	308	4	a.	a.	NOUN
admet-704	308	5	avdeef	avdeef	PROPN
admet-704	308	6	.	.	PUNCT
admet-704	309	1	absorption	absorption	NOUN
admet-704	309	2	and	and	CCONJ
admet-704	309	3	drug	drug	NOUN
admet-704	309	4	development	development	NOUN
admet-704	309	5	,	,	PUNCT
admet-704	309	6	second	second	ADJ
admet-704	309	7	edition	edition	NOUN
admet-704	309	8	.	.	PUNCT
admet-704	310	1	john	john	PROPN
admet-704	310	2	wiley	wiley	PROPN
admet-704	310	3	&	&	CCONJ
admet-704	310	4	sons	sons	PROPN
admet-704	310	5	,	,	PUNCT
admet-704	310	6	inc	inc	PROPN
admet-704	310	7	(	(	PUNCT
admet-704	310	8	2012	2012	NUM
admet-704	310	9	)	)	PUNCT
admet-704	311	1	[	[	X
admet-704	311	2	30	30	NUM
admet-704	311	3	]	]	PUNCT
admet-704	311	4	k.	k.	PROPN
admet-704	311	5	sugano	sugano	PROPN
admet-704	311	6	.	.	PUNCT
admet-704	312	1	biopharmaceutics	biopharmaceutics	NOUN
admet-704	312	2	modeling	modeling	NOUN
admet-704	312	3	and	and	CCONJ
admet-704	312	4	simulations	simulation	NOUN
admet-704	312	5	.	.	PUNCT
admet-704	313	1	wiley	wiley	PROPN
admet-704	313	2	(	(	PUNCT
admet-704	313	3	2012	2012	NUM
admet-704	313	4	)	)	PUNCT
admet-704	314	1	[	[	X
admet-704	314	2	31	31	NUM
admet-704	314	3	]	]	X
admet-704	314	4	y.	y.	PROPN
admet-704	314	5	w.	w.	PROPN
admet-704	314	6	alelyunas	alelyunas	PROPN
admet-704	314	7	,	,	PUNCT
admet-704	314	8	r.	r.	PROPN
admet-704	314	9	liu	liu	PROPN
admet-704	314	10	,	,	PUNCT
admet-704	314	11	l.	l.	PROPN
admet-704	314	12	pelosi	pelosi	PROPN
admet-704	314	13	-	-	PUNCT
admet-704	314	14	kilby	kilby	PROPN
admet-704	314	15	,	,	PUNCT
admet-704	314	16	c.	c.	PROPN
admet-704	314	17	shen	shen	PROPN
admet-704	314	18	.	.	PUNCT
admet-704	315	1	application	application	NOUN
admet-704	315	2	of	of	ADP
admet-704	315	3	a	a	DET
admet-704	315	4	dried	dry	VERB
admet-704	315	5	-	-	PUNCT
admet-704	315	6	dmso	dmso	NOUN
admet-704	315	7	rapid	rapid	ADJ
admet-704	315	8	throughput	throughput	NOUN
admet-704	315	9	24	24	NUM
admet-704	315	10	-	-	PUNCT
admet-704	315	11	h	h	NOUN
admet-704	315	12	equilibrium	equilibrium	NOUN
admet-704	315	13	solubility	solubility	NOUN
admet-704	315	14	in	in	ADP
admet-704	315	15	advancing	advance	VERB
admet-704	315	16	discovery	discovery	NOUN
admet-704	315	17	candidates	candidate	NOUN
admet-704	315	18	.	.	PUNCT
admet-704	316	1	eur	eur	PROPN
admet-704	316	2	.	.	PUNCT
admet-704	317	1	j.	j.	PROPN
admet-704	317	2	pharm	pharm	PROPN
admet-704	317	3	.	.	PUNCT
admet-704	318	1	sci	sci	PROPN
admet-704	318	2	.	.	PROPN
admet-704	319	1	37	37	NUM
admet-704	319	2	(	(	PUNCT
admet-704	319	3	2009	2009	NUM
admet-704	319	4	)	)	PUNCT
admet-704	319	5	172	172	NUM
admet-704	319	6	-	-	SYM
admet-704	319	7	182	182	NUM
admet-704	319	8	.	.	PUNCT
admet-704	320	1	asami	asami	PROPN
admet-704	320	2	ono	ono	PROPN
admet-704	320	3	et	et	PROPN
admet-704	320	4	.	.	PUNCT
admet-704	321	1	al	al	PROPN
admet-704	321	2	admet	admet	PROPN
admet-704	321	3	&	&	CCONJ
admet-704	321	4	dmpk	dmpk	PROPN
admet-704	321	5	7(3	7(3	NUM
admet-704	321	6	)	)	PUNCT
admet-704	321	7	(	(	PUNCT
admet-704	321	8	2019	2019	NUM
admet-704	321	9	)	)	PUNCT
admet-704	321	10	183	183	NUM
admet-704	321	11	-	-	SYM
admet-704	321	12	195	195	NUM
admet-704	321	13	194	194	NUM
admet-704	321	14	[	[	X
admet-704	321	15	32	32	NUM
admet-704	321	16	]	]	PUNCT
admet-704	321	17	a.	a.	NOUN
admet-704	321	18	glomme	glomme	PROPN
admet-704	321	19	,	,	PUNCT
admet-704	321	20	j.	j.	PROPN
admet-704	321	21	marz	marz	PROPN
admet-704	321	22	,	,	PUNCT
admet-704	321	23	j.	j.	PROPN
admet-704	321	24	b.	b.	PROPN
admet-704	321	25	dressman	dressman	PROPN
admet-704	321	26	.	.	PUNCT
admet-704	322	1	comparison	comparison	NOUN
admet-704	322	2	of	of	ADP
admet-704	322	3	a	a	DET
admet-704	322	4	miniaturized	miniaturize	VERB
admet-704	322	5	shake	shake	NOUN
admet-704	322	6	-	-	PUNCT
admet-704	322	7	flask	flask	NOUN
admet-704	322	8	solubility	solubility	NOUN
admet-704	322	9	method	method	NOUN
admet-704	322	10	with	with	ADP
admet-704	322	11	automated	automate	VERB
admet-704	322	12	potentiometric	potentiometric	ADJ
admet-704	322	13	acid	acid	NOUN
admet-704	322	14	/	/	SYM
admet-704	322	15	base	base	NOUN
admet-704	322	16	titrations	titration	NOUN
admet-704	322	17	and	and	CCONJ
admet-704	322	18	calculated	calculated	ADJ
admet-704	322	19	solubilities	solubility	NOUN
admet-704	322	20	.	.	PUNCT
admet-704	323	1	j.	j.	PROPN
admet-704	323	2	pharm	pharm	PROPN
admet-704	323	3	.	.	PUNCT
admet-704	324	1	sci	sci	PROPN
admet-704	324	2	.	.	PROPN
admet-704	325	1	94	94	NUM
admet-704	325	2	(	(	PUNCT
admet-704	325	3	2005	2005	NUM
admet-704	325	4	)	)	PUNCT
admet-704	325	5	116	116	NUM
admet-704	325	6	.	.	PUNCT
admet-704	326	1	[	[	X
admet-704	326	2	33	33	NUM
admet-704	326	3	]	]	PUNCT
admet-704	326	4	k.	k.	PROPN
admet-704	326	5	sugano	sugano	PROPN
admet-704	326	6	,	,	PUNCT
admet-704	326	7	t.	t.	PROPN
admet-704	326	8	kato	kato	PROPN
admet-704	326	9	,	,	PUNCT
admet-704	326	10	k.	k.	PROPN
admet-704	326	11	suzuki	suzuki	PROPN
admet-704	326	12	,	,	PUNCT
admet-704	326	13	k.	k.	PROPN
admet-704	326	14	keiko	keiko	PROPN
admet-704	326	15	,	,	PUNCT
admet-704	326	16	t.	t.	PROPN
admet-704	326	17	sujaku	sujaku	PROPN
admet-704	326	18	,	,	PUNCT
admet-704	326	19	t.	t.	PROPN
admet-704	326	20	mano	mano	PROPN
admet-704	326	21	.	.	PROPN
admet-704	327	1	high	high	ADJ
admet-704	327	2	throughput	throughput	NOUN
admet-704	327	3	solubility	solubility	NOUN
admet-704	327	4	measurement	measurement	NOUN
admet-704	327	5	with	with	ADP
admet-704	327	6	automated	automate	VERB
admet-704	327	7	polarized	polarize	VERB
admet-704	327	8	light	light	ADJ
admet-704	327	9	microscopy	microscopy	NOUN
admet-704	327	10	analysis	analysis	NOUN
admet-704	327	11	.	.	PUNCT
admet-704	328	1	j.	j.	PROPN
admet-704	328	2	pharm	pharm	PROPN
admet-704	328	3	.	.	PUNCT
admet-704	329	1	sci	sci	PROPN
admet-704	329	2	.	.	PROPN
admet-704	330	1	95	95	NUM
admet-704	330	2	(	(	PUNCT
admet-704	330	3	2006	2006	NUM
admet-704	330	4	)	)	PUNCT
admet-704	330	5	2115	2115	NUM
admet-704	330	6	-	-	SYM
admet-704	330	7	2122	2122	NUM
admet-704	330	8	.	.	PUNCT
admet-704	331	1	[	[	X
admet-704	331	2	34	34	NUM
admet-704	331	3	]	]	X
admet-704	331	4	j.	j.	PROPN
admet-704	331	5	h.	h.	PROPN
admet-704	331	6	fagerberg	fagerberg	PROPN
admet-704	331	7	,	,	PUNCT
admet-704	331	8	o.	o.	PROPN
admet-704	331	9	tsinman	tsinman	NOUN
admet-704	331	10	,	,	PUNCT
admet-704	331	11	n.	n.	PROPN
admet-704	331	12	sun	sun	PROPN
admet-704	331	13	,	,	PUNCT
admet-704	331	14	k.	k.	PROPN
admet-704	331	15	tsinman	tsinman	PROPN
admet-704	331	16	,	,	PUNCT
admet-704	331	17	a.	a.	NOUN
admet-704	331	18	avdeef	avdeef	PROPN
admet-704	331	19	,	,	PUNCT
admet-704	331	20	c.	c.	PROPN
admet-704	331	21	a.	a.	PROPN
admet-704	331	22	bergström	bergström	PROPN
admet-704	331	23	.	.	PUNCT
admet-704	332	1	dissolution	dissolution	NOUN
admet-704	332	2	rate	rate	NOUN
admet-704	332	3	and	and	CCONJ
admet-704	332	4	apparent	apparent	ADJ
admet-704	332	5	solubility	solubility	NOUN
admet-704	332	6	of	of	ADP
admet-704	332	7	poorly	poorly	ADV
admet-704	332	8	soluble	soluble	ADJ
admet-704	332	9	drugs	drug	NOUN
admet-704	332	10	in	in	ADP
admet-704	332	11	biorelevant	biorelevant	ADJ
admet-704	332	12	dissolution	dissolution	NOUN
admet-704	332	13	media	medium	NOUN
admet-704	332	14	.	.	PUNCT
admet-704	333	1	mol	mol	PROPN
admet-704	333	2	.	.	PUNCT
admet-704	333	3	pharm	pharm	PROPN
admet-704	333	4	.	.	PUNCT
admet-704	334	1	7	7	NUM
admet-704	334	2	(	(	PUNCT
admet-704	334	3	2010	2010	NUM
admet-704	334	4	)	)	PUNCT
admet-704	334	5	1419	1419	NUM
admet-704	334	6	-	-	SYM
admet-704	334	7	1430	1430	NUM
admet-704	334	8	.	.	PUNCT
admet-704	335	1	[	[	X
admet-704	335	2	35	35	NUM
admet-704	335	3	]	]	PUNCT
admet-704	335	4	j.	j.	PROPN
admet-704	335	5	h.	h.	PROPN
admet-704	335	6	fagerberg	fagerberg	PROPN
admet-704	335	7	,	,	PUNCT
admet-704	335	8	y.	y.	PROPN
admet-704	335	9	al	al	PROPN
admet-704	335	10	-	-	PUNCT
admet-704	335	11	tikriti	tikriti	PROPN
admet-704	335	12	,	,	PUNCT
admet-704	335	13	g.	g.	PROPN
admet-704	335	14	ragnarsson	ragnarsson	PROPN
admet-704	335	15	,	,	PUNCT
admet-704	335	16	c.	c.	PROPN
admet-704	335	17	a.	a.	PROPN
admet-704	335	18	bergstrom	bergstrom	PROPN
admet-704	335	19	.	.	PUNCT
admet-704	336	1	ethanol	ethanol	NOUN
admet-704	336	2	effects	effect	NOUN
admet-704	336	3	on	on	ADP
admet-704	336	4	apparent	apparent	ADJ
admet-704	336	5	solubility	solubility	NOUN
admet-704	336	6	of	of	ADP
admet-704	336	7	poorly	poorly	ADV
admet-704	336	8	soluble	soluble	ADJ
admet-704	336	9	drugs	drug	NOUN
admet-704	336	10	in	in	ADP
admet-704	336	11	simulated	simulated	ADJ
admet-704	336	12	intestinal	intestinal	ADJ
admet-704	336	13	fluid	fluid	NOUN
admet-704	336	14	.	.	PUNCT
admet-704	337	1	mol	mol	PROPN
admet-704	337	2	.	.	PUNCT
admet-704	337	3	pharm	pharm	PROPN
admet-704	337	4	.	.	PUNCT
admet-704	338	1	9	9	NUM
admet-704	338	2	(	(	PUNCT
admet-704	338	3	2012	2012	NUM
admet-704	338	4	)	)	PUNCT
admet-704	338	5	1942	1942	NUM
admet-704	338	6	-	-	SYM
admet-704	338	7	1952	1952	NUM
admet-704	338	8	.	.	PUNCT
admet-704	339	1	[	[	X
admet-704	339	2	36	36	NUM
admet-704	339	3	]	]	X
admet-704	339	4	e.	e.	PROPN
admet-704	339	5	söderlind	söderlind	PROPN
admet-704	339	6	,	,	PUNCT
admet-704	339	7	e.	e.	PROPN
admet-704	339	8	karlsson	karlsson	PROPN
admet-704	339	9	,	,	PUNCT
admet-704	339	10	a.	a.	PROPN
admet-704	339	11	carlsson	carlsson	PROPN
admet-704	339	12	,	,	PUNCT
admet-704	339	13	r.	r.	PROPN
admet-704	339	14	kong	kong	PROPN
admet-704	339	15	,	,	PUNCT
admet-704	339	16	a.	a.	PROPN
admet-704	339	17	lenz	lenz	PROPN
admet-704	339	18	,	,	PUNCT
admet-704	339	19	s.	s.	PROPN
admet-704	339	20	lindborg	lindborg	PROPN
admet-704	339	21	,	,	PUNCT
admet-704	339	22	j.	j.	PROPN
admet-704	339	23	j.	j.	PROPN
admet-704	339	24	sheng	sheng	PROPN
admet-704	339	25	.	.	PUNCT
admet-704	340	1	simulating	simulate	VERB
admet-704	340	2	fasted	fast	VERB
admet-704	340	3	human	human	ADJ
admet-704	340	4	intestinal	intestinal	ADJ
admet-704	340	5	fluids	fluid	NOUN
admet-704	340	6	:	:	PUNCT
admet-704	340	7	understanding	understand	VERB
admet-704	340	8	the	the	DET
admet-704	340	9	roles	role	NOUN
admet-704	340	10	of	of	ADP
admet-704	340	11	lecithin	lecithin	NOUN
admet-704	340	12	and	and	CCONJ
admet-704	340	13	bile	bile	NOUN
admet-704	340	14	acids	acid	NOUN
admet-704	340	15	.	.	PUNCT
admet-704	341	1	mol	mol	PROPN
admet-704	341	2	.	.	PUNCT
admet-704	341	3	pharm	pharm	PROPN
admet-704	341	4	.	.	PUNCT
admet-704	342	1	7	7	NUM
admet-704	342	2	(	(	PUNCT
admet-704	342	3	2010	2010	NUM
admet-704	342	4	)	)	PUNCT
admet-704	342	5	1498	1498	NUM
admet-704	342	6	-	-	SYM
admet-704	342	7	1507	1507	NUM
admet-704	342	8	.	.	PUNCT
admet-704	343	1	[	[	X
admet-704	343	2	37	37	NUM
admet-704	343	3	]	]	PUNCT
admet-704	343	4	r.	r.	PROPN
admet-704	343	5	takano	takano	PROPN
admet-704	343	6	,	,	PUNCT
admet-704	343	7	k.	k.	PROPN
admet-704	343	8	sugano	sugano	PROPN
admet-704	343	9	,	,	PUNCT
admet-704	343	10	a.	a.	PROPN
admet-704	343	11	higashida	higashida	PROPN
admet-704	343	12	,	,	PUNCT
admet-704	343	13	y.	y.	PROPN
admet-704	343	14	hayashi	hayashi	PROPN
admet-704	343	15	,	,	PUNCT
admet-704	343	16	m.	m.	PROPN
admet-704	343	17	machida	machida	PROPN
admet-704	343	18	,	,	PUNCT
admet-704	343	19	y.	y.	PROPN
admet-704	343	20	aso	aso	PROPN
admet-704	343	21	,	,	PUNCT
admet-704	343	22	s.	s.	PROPN
admet-704	343	23	yamashita	yamashita	PROPN
admet-704	343	24	.	.	PUNCT
admet-704	344	1	oral	oral	ADJ
admet-704	344	2	absorption	absorption	NOUN
admet-704	344	3	of	of	ADP
admet-704	344	4	poorly	poorly	ADV
admet-704	344	5	water	water	NOUN
admet-704	344	6	-	-	PUNCT
admet-704	344	7	soluble	soluble	ADJ
admet-704	344	8	drugs	drug	NOUN
admet-704	344	9	:	:	PUNCT
admet-704	344	10	computer	computer	NOUN
admet-704	344	11	simulation	simulation	NOUN
admet-704	344	12	of	of	ADP
admet-704	344	13	fraction	fraction	NOUN
admet-704	344	14	absorbed	absorb	VERB
admet-704	344	15	in	in	ADP
admet-704	344	16	humans	human	NOUN
admet-704	344	17	from	from	ADP
admet-704	344	18	a	a	DET
admet-704	344	19	miniscale	miniscale	ADJ
admet-704	344	20	dissolution	dissolution	NOUN
admet-704	344	21	test	test	NOUN
admet-704	344	22	.	.	PUNCT
admet-704	345	1	pharm	pharm	NOUN
admet-704	345	2	.	.	PUNCT
admet-704	346	1	res	re	NOUN
admet-704	346	2	.	.	PUNCT
admet-704	347	1	23	23	NUM
admet-704	347	2	(	(	PUNCT
admet-704	347	3	2006	2006	NUM
admet-704	347	4	)	)	PUNCT
admet-704	347	5	1144	1144	NUM
admet-704	347	6	-	-	SYM
admet-704	347	7	1156	1156	NUM
admet-704	347	8	.	.	PUNCT
admet-704	348	1	[	[	X
admet-704	348	2	38	38	NUM
admet-704	348	3	]	]	PUNCT
admet-704	348	4	s.	s.	PROPN
admet-704	348	5	clarysse	clarysse	PROPN
admet-704	348	6	,	,	PUNCT
admet-704	348	7	j.	j.	PROPN
admet-704	348	8	brouwers	brouwers	PROPN
admet-704	348	9	,	,	PUNCT
admet-704	348	10	j.	j.	PROPN
admet-704	348	11	tack	tack	PROPN
admet-704	348	12	,	,	PUNCT
admet-704	348	13	p.	p.	PROPN
admet-704	348	14	annaert	annaert	NOUN
admet-704	348	15	,	,	PUNCT
admet-704	348	16	p.	p.	NOUN
admet-704	348	17	augustijns	augustijns	NOUN
admet-704	348	18	.	.	PUNCT
admet-704	349	1	intestinal	intestinal	ADJ
admet-704	349	2	drug	drug	NOUN
admet-704	349	3	solubility	solubility	NOUN
admet-704	349	4	estimation	estimation	NOUN
admet-704	349	5	based	base	VERB
admet-704	349	6	on	on	ADP
admet-704	349	7	simulated	simulated	ADJ
admet-704	349	8	intestinal	intestinal	ADJ
admet-704	349	9	fluids	fluid	NOUN
admet-704	349	10	:	:	PUNCT
admet-704	349	11	comparison	comparison	NOUN
admet-704	349	12	with	with	ADP
admet-704	349	13	solubility	solubility	NOUN
admet-704	349	14	in	in	ADP
admet-704	349	15	human	human	ADJ
admet-704	349	16	intestinal	intestinal	ADJ
admet-704	349	17	fluids	fluid	NOUN
admet-704	349	18	.	.	PUNCT
admet-704	350	1	eur	eur	PROPN
admet-704	350	2	.	.	PUNCT
admet-704	351	1	j.	j.	PROPN
admet-704	351	2	pharm	pharm	PROPN
admet-704	351	3	.	.	PUNCT
admet-704	352	1	sci	sci	PROPN
admet-704	352	2	.	.	PROPN
admet-704	353	1	43	43	NUM
admet-704	353	2	(	(	PUNCT
admet-704	353	3	2011	2011	NUM
admet-704	353	4	)	)	PUNCT
admet-704	353	5	260	260	NUM
admet-704	353	6	-	-	SYM
admet-704	353	7	269	269	NUM
admet-704	353	8	.	.	PUNCT
admet-704	354	1	[	[	X
admet-704	354	2	39	39	NUM
admet-704	354	3	]	]	PUNCT
admet-704	354	4	a.	a.	NOUN
admet-704	354	5	avdeef	avdeef	PROPN
admet-704	354	6	,	,	PUNCT
admet-704	354	7	o.	o.	PROPN
admet-704	354	8	tsinman	tsinman	NOUN
admet-704	354	9	.	.	PUNCT
admet-704	355	1	miniaturized	miniaturize	VERB
admet-704	355	2	rotating	rotating	NOUN
admet-704	355	3	disk	disk	NOUN
admet-704	355	4	intrinsic	intrinsic	ADJ
admet-704	355	5	dissolution	dissolution	NOUN
admet-704	355	6	rate	rate	NOUN
admet-704	355	7	measurement	measurement	NOUN
admet-704	355	8	:	:	PUNCT
admet-704	355	9	effects	effect	NOUN
admet-704	355	10	of	of	ADP
admet-704	355	11	buffer	buffer	NOUN
admet-704	355	12	capacity	capacity	NOUN
admet-704	355	13	in	in	ADP
admet-704	355	14	comparisons	comparison	NOUN
admet-704	355	15	to	to	ADP
admet-704	355	16	traditional	traditional	ADJ
admet-704	355	17	wood	wood	NOUN
admet-704	355	18	’s	’s	PART
admet-704	355	19	apparatus	apparatus	NOUN
admet-704	355	20	.	.	PUNCT
admet-704	356	1	pharm	pharm	PROPN
admet-704	356	2	.	.	PUNCT
admet-704	357	1	res	re	NOUN
admet-704	357	2	.	.	PROPN
admet-704	358	1	25	25	NUM
admet-704	358	2	(	(	PUNCT
admet-704	358	3	2008	2008	NUM
admet-704	358	4	)	)	PUNCT
admet-704	358	5	2613	2613	NUM
admet-704	358	6	-	-	SYM
admet-704	358	7	2627	2627	NUM
admet-704	358	8	.	.	PUNCT
admet-704	359	1	[	[	X
admet-704	359	2	40	40	NUM
admet-704	359	3	]	]	PUNCT
admet-704	359	4	a.	a.	NOUN
admet-704	359	5	avdeef	avdeef	PROPN
admet-704	359	6	.	.	PUNCT
admet-704	360	1	solubility	solubility	NOUN
admet-704	360	2	temperature	temperature	NOUN
admet-704	360	3	dependence	dependence	NOUN
admet-704	360	4	predicted	predict	VERB
admet-704	360	5	from	from	ADP
admet-704	360	6	2d	2d	NUM
admet-704	360	7	structure	structure	NOUN
admet-704	360	8	.	.	PUNCT
admet-704	361	1	admet	admet	PROPN
admet-704	361	2	&	&	CCONJ
admet-704	361	3	dmpk	dmpk	PROPN
admet-704	361	4	3	3	NUM
admet-704	361	5	(	(	PUNCT
admet-704	361	6	2015	2015	NUM
admet-704	361	7	)	)	PUNCT
admet-704	362	1	[	[	X
admet-704	362	2	41	41	NUM
admet-704	362	3	]	]	PUNCT
admet-704	362	4	k.	k.	PROPN
admet-704	362	5	sugano	sugano	PROPN
admet-704	362	6	,	,	PUNCT
admet-704	362	7	h.	h.	PROPN
admet-704	362	8	hamada	hamada	PROPN
admet-704	362	9	,	,	PUNCT
admet-704	362	10	m.	m.	PROPN
admet-704	362	11	machida	machida	PROPN
admet-704	362	12	,	,	PUNCT
admet-704	362	13	h.	h.	PROPN
admet-704	362	14	ushio	ushio	PROPN
admet-704	362	15	.	.	PUNCT
admet-704	363	1	high	high	ADJ
admet-704	363	2	throughput	throughput	NOUN
admet-704	363	3	prediction	prediction	NOUN
admet-704	363	4	of	of	ADP
admet-704	363	5	oral	oral	ADJ
admet-704	363	6	absorption	absorption	NOUN
admet-704	363	7	:	:	PUNCT
admet-704	363	8	improvement	improvement	NOUN
admet-704	363	9	of	of	ADP
admet-704	363	10	the	the	DET
admet-704	363	11	composition	composition	NOUN
admet-704	363	12	of	of	ADP
admet-704	363	13	the	the	DET
admet-704	363	14	lipid	lipid	NOUN
admet-704	363	15	solution	solution	NOUN
admet-704	363	16	used	use	VERB
admet-704	363	17	in	in	ADP
admet-704	363	18	parallel	parallel	ADJ
admet-704	363	19	artificial	artificial	ADJ
admet-704	363	20	membrane	membrane	NOUN
admet-704	363	21	permeation	permeation	NOUN
admet-704	363	22	assay	assay	NOUN
admet-704	363	23	.	.	PUNCT
admet-704	364	1	journal	journal	NOUN
admet-704	364	2	of	of	ADP
admet-704	364	3	biomolecular	biomolecular	ADJ
admet-704	364	4	screening	screen	VERB
admet-704	364	5	6	6	NUM
admet-704	364	6	(	(	PUNCT
admet-704	364	7	2001	2001	NUM
admet-704	364	8	)	)	PUNCT
admet-704	364	9	189	189	NUM
admet-704	364	10	-	-	SYM
admet-704	364	11	196	196	NUM
admet-704	364	12	.	.	PUNCT
admet-704	365	1	[	[	X
admet-704	365	2	42	42	NUM
admet-704	365	3	]	]	PUNCT
admet-704	365	4	k.	k.	PROPN
admet-704	365	5	kawakami	kawakami	PROPN
admet-704	365	6	,	,	PUNCT
admet-704	365	7	k.	k.	PROPN
admet-704	365	8	miyoshi	miyoshi	PROPN
admet-704	365	9	,	,	PUNCT
admet-704	365	10	y.	y.	PROPN
admet-704	365	11	ida	ida	PROPN
admet-704	365	12	.	.	PUNCT
admet-704	365	13	impact	impact	NOUN
admet-704	365	14	of	of	ADP
admet-704	365	15	the	the	DET
admet-704	365	16	amount	amount	NOUN
admet-704	365	17	of	of	ADP
admet-704	365	18	excess	excess	ADJ
admet-704	365	19	solids	solid	NOUN
admet-704	365	20	on	on	ADP
admet-704	365	21	apparent	apparent	ADJ
admet-704	365	22	solubility	solubility	NOUN
admet-704	365	23	.	.	PUNCT
admet-704	366	1	pharm	pharm	NOUN
admet-704	366	2	.	.	PUNCT
admet-704	367	1	res	re	NOUN
admet-704	367	2	.	.	PUNCT
admet-704	368	1	22	22	NUM
admet-704	368	2	(	(	PUNCT
admet-704	368	3	2005	2005	NUM
admet-704	368	4	)	)	PUNCT
admet-704	368	5	1537	1537	NUM
admet-704	368	6	-	-	SYM
admet-704	368	7	1543	1543	NUM
admet-704	368	8	.	.	PUNCT
admet-704	369	1	[	[	X
admet-704	369	2	43	43	NUM
admet-704	369	3	]	]	X
admet-704	369	4	e.	e.	PROPN
admet-704	369	5	baka	baka	PROPN
admet-704	369	6	,	,	PUNCT
admet-704	369	7	j.	j.	PROPN
admet-704	369	8	e.	e.	PROPN
admet-704	369	9	comer	comer	PROPN
admet-704	369	10	,	,	PUNCT
admet-704	369	11	k.	k.	PROPN
admet-704	369	12	takacs	takacs	PROPN
admet-704	369	13	-	-	PUNCT
admet-704	369	14	novak	novak	PROPN
admet-704	369	15	.	.	PUNCT
admet-704	370	1	study	study	NOUN
admet-704	370	2	of	of	ADP
admet-704	370	3	equilibrium	equilibrium	NOUN
admet-704	370	4	solubility	solubility	NOUN
admet-704	370	5	measurement	measurement	NOUN
admet-704	370	6	by	by	ADP
admet-704	370	7	saturation	saturation	NOUN
admet-704	370	8	shake	shake	NOUN
admet-704	370	9	-	-	PUNCT
admet-704	370	10	flask	flask	NOUN
admet-704	370	11	method	method	NOUN
admet-704	370	12	using	use	VERB
admet-704	370	13	hydrochlorothiazide	hydrochlorothiazide	PROPN
admet-704	370	14	as	as	ADP
admet-704	370	15	model	model	NOUN
admet-704	370	16	compound	compound	PROPN
admet-704	370	17	.	.	PUNCT
admet-704	371	1	j.	j.	PROPN
admet-704	371	2	pharm	pharm	PROPN
admet-704	371	3	.	.	PUNCT
admet-704	371	4	biomed	biome	VERB
admet-704	371	5	.	.	PUNCT
admet-704	372	1	anal	anal	ADJ
admet-704	372	2	.	.	PUNCT
admet-704	373	1	46	46	NUM
admet-704	373	2	(	(	PUNCT
admet-704	373	3	2008	2008	NUM
admet-704	373	4	)	)	PUNCT
admet-704	373	5	335	335	NUM
admet-704	373	6	-	-	SYM
admet-704	373	7	341	341	NUM
admet-704	373	8	.	.	PUNCT
admet-704	374	1	[	[	X
admet-704	374	2	44	44	NUM
admet-704	374	3	]	]	PUNCT
admet-704	374	4	l.	l.	PROPN
admet-704	374	5	pan	pan	PROPN
admet-704	374	6	,	,	PUNCT
admet-704	374	7	q.	q.	PROPN
admet-704	374	8	ho	ho	PROPN
admet-704	374	9	,	,	PUNCT
admet-704	374	10	k.	k.	PROPN
admet-704	374	11	tsutsui	tsutsui	PROPN
admet-704	374	12	,	,	PUNCT
admet-704	374	13	l.	l.	PROPN
admet-704	374	14	takahashi	takahashi	PROPN
admet-704	374	15	.	.	PUNCT
admet-704	375	1	comparison	comparison	NOUN
admet-704	375	2	of	of	ADP
admet-704	375	3	chromatographic	chromatographic	ADJ
admet-704	375	4	and	and	CCONJ
admet-704	375	5	spectroscopic	spectroscopic	ADJ
admet-704	375	6	methods	method	NOUN
admet-704	375	7	used	use	VERB
admet-704	375	8	to	to	PART
admet-704	375	9	rank	rank	VERB
admet-704	375	10	compounds	compound	NOUN
admet-704	375	11	for	for	ADP
admet-704	375	12	aqueous	aqueous	ADJ
admet-704	375	13	solubility	solubility	NOUN
admet-704	375	14	.	.	PUNCT
admet-704	376	1	j.	j.	PROPN
admet-704	376	2	pharm	pharm	PROPN
admet-704	376	3	.	.	PUNCT
admet-704	377	1	sci	sci	PROPN
admet-704	377	2	.	.	PROPN
admet-704	378	1	90	90	NUM
admet-704	378	2	(	(	PUNCT
admet-704	378	3	2001	2001	NUM
admet-704	378	4	)	)	PUNCT
admet-704	378	5	521	521	NUM
admet-704	378	6	-	-	SYM
admet-704	378	7	529	529	NUM
admet-704	378	8	.	.	PUNCT
admet-704	379	1	[	[	X
admet-704	379	2	45	45	NUM
admet-704	379	3	]	]	PUNCT
admet-704	379	4	m.	m.	NOUN
admet-704	379	5	lindenberg	lindenberg	PROPN
admet-704	379	6	,	,	PUNCT
admet-704	379	7	c.	c.	PROPN
admet-704	379	8	wiegand	wiegand	PROPN
admet-704	379	9	,	,	PUNCT
admet-704	379	10	j.	j.	PROPN
admet-704	379	11	b.	b.	PROPN
admet-704	379	12	dressman	dressman	PROPN
admet-704	379	13	.	.	PUNCT
admet-704	380	1	comparison	comparison	NOUN
admet-704	380	2	of	of	ADP
admet-704	380	3	the	the	DET
admet-704	380	4	adsorption	adsorption	NOUN
admet-704	380	5	of	of	ADP
admet-704	380	6	several	several	ADJ
admet-704	380	7	drugs	drug	NOUN
admet-704	380	8	to	to	ADP
admet-704	380	9	typical	typical	ADJ
admet-704	380	10	filter	filter	NOUN
admet-704	380	11	materials	material	NOUN
admet-704	380	12	.	.	PUNCT
admet-704	381	1	dissolution	dissolution	PROPN
admet-704	381	2	technologies	technology	NOUN
admet-704	381	3	12	12	NUM
admet-704	381	4	(	(	PUNCT
admet-704	381	5	2005	2005	NUM
admet-704	381	6	)	)	PUNCT
admet-704	381	7	22	22	NUM
admet-704	381	8	-	-	SYM
admet-704	381	9	25	25	NUM
admet-704	381	10	.	.	PUNCT
admet-704	382	1	[	[	X
admet-704	382	2	46	46	NUM
admet-704	382	3	]	]	X
admet-704	382	4	g.	g.	PROPN
admet-704	382	5	volgyi	volgyi	PROPN
admet-704	382	6	,	,	PUNCT
admet-704	382	7	d.	d.	PROPN
admet-704	382	8	csicsak	csicsak	PROPN
admet-704	382	9	and	and	CCONJ
admet-704	382	10	k.	k.	PROPN
admet-704	382	11	takacs	takacs	PROPN
admet-704	382	12	-	-	PUNCT
admet-704	382	13	novak	novak	PROPN
admet-704	382	14	.	.	PUNCT
admet-704	383	1	right	right	ADJ
admet-704	383	2	filter	filter	NOUN
admet-704	383	3	-	-	PUNCT
admet-704	383	4	selection	selection	NOUN
admet-704	383	5	for	for	ADP
admet-704	383	6	phase	phase	NOUN
admet-704	383	7	separation	separation	NOUN
admet-704	383	8	in	in	ADP
admet-704	383	9	equilibrium	equilibrium	NOUN
admet-704	383	10	solubility	solubility	NOUN
admet-704	383	11	measurement	measurement	NOUN
admet-704	383	12	.	.	PUNCT
admet-704	384	1	eur	eur	PROPN
admet-704	384	2	.	.	PUNCT
admet-704	385	1	j.	j.	PROPN
admet-704	385	2	pharm	pharm	PROPN
admet-704	385	3	.	.	PUNCT
admet-704	386	1	sci	sci	PROPN
admet-704	386	2	.	.	PROPN
admet-704	387	1	123	123	NUM
admet-704	387	2	(	(	PUNCT
admet-704	387	3	2018	2018	NUM
admet-704	387	4	)	)	PUNCT
admet-704	387	5	98	98	NUM
admet-704	387	6	-	-	SYM
admet-704	387	7	105	105	NUM
admet-704	387	8	.	.	PUNCT
admet-704	388	1	[	[	X
admet-704	388	2	47	47	NUM
admet-704	388	3	]	]	PUNCT
admet-704	388	4	j.	j.	PROPN
admet-704	388	5	j.	j.	PROPN
admet-704	388	6	palmgren	palmgren	PROPN
admet-704	388	7	,	,	PUNCT
admet-704	388	8	j.	j.	PROPN
admet-704	388	9	monkkonen	monkkonen	PROPN
admet-704	388	10	,	,	PUNCT
admet-704	388	11	t.	t.	NOUN
admet-704	388	12	korjamo	korjamo	PROPN
admet-704	388	13	,	,	PUNCT
admet-704	388	14	a.	a.	PROPN
admet-704	388	15	hassinen	hassinen	PROPN
admet-704	388	16	,	,	PUNCT
admet-704	388	17	s.	s.	PROPN
admet-704	388	18	auriola	auriola	PROPN
admet-704	388	19	.	.	PUNCT
admet-704	389	1	drug	drug	NOUN
admet-704	389	2	adsorption	adsorption	NOUN
admet-704	389	3	to	to	ADP
admet-704	389	4	plastic	plastic	ADJ
admet-704	389	5	containers	container	NOUN
admet-704	389	6	and	and	CCONJ
admet-704	389	7	retention	retention	NOUN
admet-704	389	8	of	of	ADP
admet-704	389	9	drugs	drug	NOUN
admet-704	389	10	in	in	ADP
admet-704	389	11	cultured	cultured	ADJ
admet-704	389	12	cells	cell	NOUN
admet-704	389	13	under	under	ADP
admet-704	389	14	in	in	ADP
admet-704	389	15	vitro	vitro	X
admet-704	389	16	conditions	condition	NOUN
admet-704	389	17	.	.	PUNCT
admet-704	390	1	eur	eur	PROPN
admet-704	390	2	.	.	PUNCT
admet-704	391	1	j.	j.	PROPN
admet-704	391	2	pharm	pharm	PROPN
admet-704	391	3	.	.	PUNCT
admet-704	392	1	biopharm	biopharm	PROPN
admet-704	392	2	.	.	PUNCT
admet-704	393	1	64	64	NUM
admet-704	393	2	(	(	PUNCT
admet-704	393	3	2006	2006	NUM
admet-704	393	4	)	)	PUNCT
admet-704	393	5	369	369	NUM
admet-704	393	6	-	-	SYM
admet-704	393	7	378	378	NUM
admet-704	393	8	.	.	PUNCT
admet-704	394	1	[	[	X
admet-704	394	2	48	48	NUM
admet-704	394	3	]	]	PUNCT
admet-704	394	4	t.	t.	PROPN
admet-704	394	5	fukazawa	fukazawa	PROPN
admet-704	394	6	,	,	PUNCT
admet-704	394	7	y.	y.	PROPN
admet-704	394	8	yamazaki	yamazaki	PROPN
admet-704	394	9	,	,	PUNCT
admet-704	394	10	y.	y.	PROPN
admet-704	394	11	miyamoto	miyamoto	PROPN
admet-704	394	12	.	.	PUNCT
admet-704	394	13	reduction	reduction	NOUN
admet-704	394	14	of	of	ADP
admet-704	394	15	non	non	ADJ
admet-704	394	16	-	-	ADJ
admet-704	394	17	specific	specific	ADJ
admet-704	394	18	adsorption	adsorption	NOUN
admet-704	394	19	of	of	ADP
admet-704	394	20	drugs	drug	NOUN
admet-704	394	21	to	to	ADP
admet-704	394	22	plastic	plastic	ADJ
admet-704	394	23	containers	container	NOUN
admet-704	394	24	used	use	VERB
admet-704	394	25	in	in	ADP
admet-704	394	26	bioassays	bioassay	NOUN
admet-704	394	27	or	or	CCONJ
admet-704	394	28	analyses	analysis	NOUN
admet-704	394	29	.	.	PUNCT
admet-704	395	1	j.	j.	PROPN
admet-704	395	2	pharmacol	pharmacol	PROPN
admet-704	395	3	.	.	PUNCT
admet-704	396	1	toxicol	toxicol	PROPN
admet-704	396	2	.	.	PUNCT
admet-704	397	1	methods	method	NOUN
admet-704	397	2	61	61	NUM
admet-704	397	3	(	(	PUNCT
admet-704	397	4	2010	2010	NUM
admet-704	397	5	)	)	PUNCT
admet-704	397	6	329	329	NUM
admet-704	397	7	-	-	SYM
admet-704	397	8	333	333	NUM
admet-704	397	9	.	.	PUNCT
admet-704	398	1	[	[	X
admet-704	398	2	49	49	NUM
admet-704	398	3	]	]	PUNCT
admet-704	398	4	t.	t.	PROPN
admet-704	398	5	tokumura	tokumura	PROPN
admet-704	398	6	.	.	PUNCT
admet-704	399	1	a	a	DET
admet-704	399	2	screening	screening	NOUN
admet-704	399	3	system	system	NOUN
admet-704	399	4	of	of	ADP
admet-704	399	5	solubility	solubility	NOUN
admet-704	399	6	for	for	ADP
admet-704	399	7	drug	drug	NOUN
admet-704	399	8	design	design	NOUN
admet-704	399	9	and	and	CCONJ
admet-704	399	10	discovery	discovery	NOUN
admet-704	399	11	.	.	PUNCT
admet-704	400	1	pharm	pharm	PROPN
admet-704	400	2	tech	tech	PROPN
admet-704	400	3	japan	japan	PROPN
admet-704	400	4	16	16	NUM
admet-704	400	5	(	(	PUNCT
admet-704	400	6	2000	2000	NUM
admet-704	400	7	)	)	PUNCT
admet-704	400	8	19	19	NUM
admet-704	400	9	-	-	SYM
admet-704	400	10	27	27	NUM
admet-704	400	11	.	.	PUNCT
admet-704	401	1	[	[	X
admet-704	401	2	50	50	NUM
admet-704	401	3	]	]	PUNCT
admet-704	401	4	j.	j.	PROPN
admet-704	401	5	oki	oki	PROPN
admet-704	401	6	,	,	PUNCT
admet-704	401	7	d.	d.	PROPN
admet-704	401	8	watanabe	watanabe	PROPN
admet-704	401	9	,	,	PUNCT
admet-704	401	10	t.	t.	PROPN
admet-704	401	11	uekusa	uekusa	PROPN
admet-704	401	12	,	,	PUNCT
admet-704	401	13	k.	k.	PROPN
admet-704	401	14	sugano	sugano	PROPN
admet-704	401	15	.	.	PUNCT
admet-704	402	1	mechanism	mechanism	NOUN
admet-704	402	2	of	of	ADP
admet-704	402	3	supersaturation	supersaturation	NOUN
admet-704	402	4	suppression	suppression	NOUN
admet-704	402	5	in	in	ADP
admet-704	402	6	dissolution	dissolution	ADJ
admet-704	402	7	process	process	NOUN
admet-704	402	8	of	of	ADP
admet-704	402	9	acidic	acidic	ADJ
admet-704	402	10	drug	drug	NOUN
admet-704	402	11	salt	salt	NOUN
admet-704	402	12	.	.	PUNCT
admet-704	403	1	mol	mol	PROPN
admet-704	403	2	.	.	PUNCT
admet-704	403	3	pharm	pharm	PROPN
admet-704	403	4	.	.	PUNCT
admet-704	404	1	16	16	NUM
admet-704	404	2	(	(	PUNCT
admet-704	404	3	2019	2019	NUM
admet-704	404	4	)	)	PUNCT
admet-704	404	5	1669	1669	NUM
admet-704	404	6	-	-	SYM
admet-704	404	7	1677	1677	NUM
admet-704	404	8	.	.	PUNCT
admet-704	405	1	[	[	X
admet-704	405	2	51	51	NUM
admet-704	405	3	]	]	X
admet-704	405	4	t.	t.	NOUN
admet-704	405	5	uekusa	uekusa	PROPN
admet-704	405	6	,	,	PUNCT
admet-704	405	7	k.	k.	PROPN
admet-704	405	8	sugano	sugano	PROPN
admet-704	405	9	.	.	PUNCT
admet-704	406	1	precipitation	precipitation	NOUN
admet-704	406	2	behavior	behavior	NOUN
admet-704	406	3	of	of	ADP
admet-704	406	4	pioglitazone	pioglitazone	NOUN
admet-704	406	5	on	on	ADP
admet-704	406	6	the	the	DET
admet-704	406	7	particle	particle	NOUN
admet-704	406	8	surface	surface	NOUN
admet-704	406	9	of	of	ADP
admet-704	406	10	hydrochloride	hydrochloride	NOUN
admet-704	406	11	salt	salt	NOUN
admet-704	406	12	in	in	ADP
admet-704	406	13	biorelevant	biorelevant	ADJ
admet-704	406	14	media	medium	NOUN
admet-704	406	15	.	.	PUNCT
admet-704	407	1	j.	j.	PROPN
admet-704	407	2	pharm	pharm	PROPN
admet-704	407	3	.	.	PUNCT
admet-704	407	4	biomed	biome	VERB
admet-704	407	5	.	.	PUNCT
admet-704	408	1	anal	anal	ADJ
admet-704	408	2	.	.	PUNCT
admet-704	409	1	161	161	NUM
admet-704	409	2	(	(	PUNCT
admet-704	409	3	2018	2018	NUM
admet-704	409	4	)	)	PUNCT
admet-704	409	5	45	45	NUM
admet-704	409	6	-	-	SYM
admet-704	409	7	50	50	NUM
admet-704	409	8	.	.	PUNCT
admet-704	410	1	[	[	X
admet-704	410	2	52	52	NUM
admet-704	410	3	]	]	PUNCT
admet-704	410	4	e.	e.	PROPN
admet-704	410	5	shoghi	shoghi	PROPN
admet-704	410	6	,	,	PUNCT
admet-704	410	7	e.	e.	PROPN
admet-704	410	8	fuguet	fuguet	PROPN
admet-704	410	9	,	,	PUNCT
admet-704	410	10	e.	e.	PROPN
admet-704	410	11	bosch	bosch	PROPN
admet-704	410	12	and	and	CCONJ
admet-704	410	13	c.	c.	PROPN
admet-704	410	14	rafols	rafols	PROPN
admet-704	410	15	.	.	PUNCT
admet-704	411	1	solubility	solubility	NOUN
admet-704	411	2	-	-	PUNCT
admet-704	411	3	ph	ph	ADJ
admet-704	411	4	profiles	profile	NOUN
admet-704	411	5	of	of	ADP
admet-704	411	6	some	some	DET
admet-704	411	7	acidic	acidic	ADJ
admet-704	411	8	,	,	PUNCT
admet-704	411	9	basic	basic	ADJ
admet-704	411	10	and	and	CCONJ
admet-704	411	11	amphoteric	amphoteric	ADJ
admet-704	411	12	drugs	drug	NOUN
admet-704	411	13	.	.	PUNCT
admet-704	412	1	eur	eur	PROPN
admet-704	412	2	.	.	PUNCT
admet-704	413	1	j.	j.	PROPN
admet-704	413	2	pharm	pharm	PROPN
admet-704	413	3	.	.	PUNCT
admet-704	414	1	sci	sci	PROPN
admet-704	414	2	.	.	PROPN
admet-704	415	1	48	48	NUM
admet-704	415	2	(	(	PUNCT
admet-704	415	3	2013	2013	NUM
admet-704	415	4	)	)	PUNCT
admet-704	415	5	291	291	NUM
admet-704	415	6	-	-	SYM
admet-704	415	7	300	300	NUM
admet-704	415	8	.	.	PUNCT
admet-704	416	1	[	[	X
admet-704	416	2	53	53	NUM
admet-704	416	3	]	]	PUNCT
admet-704	416	4	o.	o.	PROPN
admet-704	416	5	s.	s.	PROPN
admet-704	416	6	markovic	markovic	PROPN
admet-704	416	7	,	,	PUNCT
admet-704	416	8	m.	m.	NOUN
admet-704	416	9	p.	p.	NOUN
admet-704	416	10	pesic	pesic	NOUN
admet-704	416	11	,	,	PUNCT
admet-704	416	12	a.	a.	NOUN
admet-704	416	13	v.	v.	PROPN
admet-704	416	14	shah	shah	PROPN
admet-704	416	15	,	,	PUNCT
admet-704	416	16	a.	a.	NOUN
admet-704	416	17	t.	t.	PROPN
admet-704	416	18	m.	m.	PROPN
admet-704	416	19	serajuddin	serajuddin	PROPN
admet-704	416	20	,	,	PUNCT
admet-704	416	21	t.	t.	PROPN
admet-704	416	22	z.	z.	PROPN
admet-704	416	23	verbic	verbic	PROPN
admet-704	416	24	and	and	CCONJ
admet-704	416	25	a.	a.	NOUN
admet-704	416	26	avdeef	avdeef	PROPN
admet-704	416	27	.	.	PUNCT
admet-704	417	1	solubility	solubility	NOUN
admet-704	417	2	-	-	PUNCT
admet-704	417	3	ph	ph	NOUN
admet-704	417	4	profile	profile	NOUN
admet-704	417	5	of	of	ADP
admet-704	417	6	desipramine	desipramine	NOUN
admet-704	417	7	hydrochloride	hydrochloride	NOUN
admet-704	417	8	in	in	ADP
admet-704	417	9	saline	saline	ADJ
admet-704	417	10	phosphate	phosphate	NOUN
admet-704	417	11	buffer	buffer	NOUN
admet-704	417	12	:	:	PUNCT
admet-704	417	13	enhanced	enhance	VERB
admet-704	417	14	solubility	solubility	NOUN
admet-704	417	15	due	due	ADP
admet-704	417	16	to	to	PART
admet-704	417	17	drugbuffer	drugbuffer	VERB
admet-704	417	18	aggregates	aggregate	NOUN
admet-704	417	19	.	.	PUNCT
admet-704	418	1	eur	eur	PROPN
admet-704	418	2	.	.	PUNCT
admet-704	419	1	j.	j.	PROPN
admet-704	419	2	pharm	pharm	PROPN
admet-704	419	3	.	.	PUNCT
admet-704	420	1	sci	sci	PROPN
admet-704	420	2	.	.	PROPN
admet-704	421	1	133	133	NUM
admet-704	421	2	(	(	PUNCT
admet-704	421	3	2019	2019	NUM
admet-704	421	4	)	)	PUNCT
admet-704	421	5	264	264	NUM
admet-704	421	6	-	-	SYM
admet-704	421	7	274	274	NUM
admet-704	421	8	.	.	PUNCT
admet-704	422	1	admet	admet	PROPN
admet-704	422	2	&	&	CCONJ
admet-704	422	3	dmpk	dmpk	PROPN
admet-704	422	4	7(3	7(3	NUM
admet-704	422	5	)	)	PUNCT
admet-704	422	6	(	(	PUNCT
admet-704	422	7	2019	2019	NUM
admet-704	422	8	)	)	PUNCT
admet-704	422	9	183	183	NUM
admet-704	422	10	-	-	SYM
admet-704	422	11	195	195	NUM
admet-704	422	12	harmonizing	harmonize	VERB
admet-704	422	13	solubility	solubility	NOUN
admet-704	422	14	measurement	measurement	NOUN
admet-704	422	15	to	to	PART
admet-704	422	16	lower	lower	VERB
admet-704	422	17	inter	inter	ADJ
admet-704	422	18	-	-	ADJ
admet-704	422	19	laboratory	laboratory	ADJ
admet-704	422	20	variance	variance	NOUN
admet-704	422	21	doi	doi	NOUN
admet-704	422	22	:	:	PUNCT
admet-704	422	23	10.5599	10.5599	NUM
admet-704	422	24	/	/	SYM
admet-704	422	25	admet.704	admet.704	ADP
admet-704	422	26	195	195	NUM
admet-704	422	27	[	[	X
admet-704	422	28	54	54	NUM
admet-704	422	29	]	]	X
admet-704	422	30	y.	y.	PROPN
admet-704	422	31	akiyama	akiyama	PROPN
admet-704	422	32	,	,	PUNCT
admet-704	422	33	t.	t.	PROPN
admet-704	422	34	kimoto	kimoto	PROPN
admet-704	422	35	,	,	PUNCT
admet-704	422	36	h.	h.	PROPN
admet-704	422	37	mukumoto	mukumoto	PROPN
admet-704	422	38	,	,	PUNCT
admet-704	422	39	s.	s.	PROPN
admet-704	422	40	miyake	miyake	PROPN
admet-704	422	41	,	,	PUNCT
admet-704	422	42	s.	s.	PROPN
admet-704	422	43	ito	ito	PROPN
admet-704	422	44	,	,	PUNCT
admet-704	422	45	t.	t.	PROPN
admet-704	422	46	taniguchi	taniguchi	PROPN
admet-704	422	47	,	,	PUNCT
admet-704	422	48	y.	y.	PROPN
admet-704	422	49	nomura	nomura	PROPN
admet-704	422	50	,	,	PUNCT
admet-704	422	51	n.	n.	PROPN
admet-704	422	52	matsumura	matsumura	ADV
admet-704	422	53	,	,	PUNCT
admet-704	422	54	t.	t.	PROPN
admet-704	422	55	fujita	fujita	PROPN
admet-704	422	56	,	,	PUNCT
admet-704	422	57	k.	k.	PROPN
admet-704	422	58	sugano	sugano	PROPN
admet-704	422	59	.	.	PUNCT
admet-704	423	1	prediction	prediction	NOUN
admet-704	423	2	accuracy	accuracy	NOUN
admet-704	423	3	of	of	ADP
admet-704	423	4	mechanism	mechanism	NOUN
admet-704	423	5	-	-	PUNCT
admet-704	423	6	based	base	VERB
admet-704	423	7	oral	oral	ADJ
admet-704	423	8	absorption	absorption	NOUN
admet-704	423	9	model	model	NOUN
admet-704	423	10	for	for	ADP
admet-704	423	11	dogs	dog	NOUN
admet-704	423	12	.	.	PUNCT
admet-704	424	1	j.	j.	PROPN
admet-704	424	2	pharm	pharm	PROPN
admet-704	424	3	.	.	PUNCT
admet-704	425	1	sci	sci	PROPN
admet-704	425	2	.	.	PUNCT
admet-704	426	1	(	(	PUNCT
admet-704	426	2	2019	2019	NUM
admet-704	426	3	)	)	PUNCT
admet-704	426	4	.	.	PUNCT
admet-704	427	1	©	©	PROPN
admet-704	427	2	2019	2019	NUM
admet-704	427	3	by	by	ADP
admet-704	427	4	the	the	DET
admet-704	427	5	authors	author	NOUN
admet-704	427	6	;	;	PUNCT
admet-704	427	7	licensee	licensee	PROPN
admet-704	427	8	iapc	iapc	PROPN
admet-704	427	9	,	,	PUNCT
admet-704	427	10	zagreb	zagreb	PROPN
admet-704	427	11	,	,	PUNCT
admet-704	427	12	croatia	croatia	PROPN
admet-704	427	13	.	.	PUNCT
admet-704	428	1	this	this	DET
admet-704	428	2	article	article	NOUN
admet-704	428	3	is	be	AUX
admet-704	428	4	an	an	DET
admet-704	428	5	open	open	ADJ
admet-704	428	6	-	-	PUNCT
admet-704	428	7	access	access	NOUN
admet-704	428	8	article	article	NOUN
admet-704	428	9	distributed	distribute	VERB
admet-704	428	10	under	under	ADP
admet-704	428	11	the	the	DET
admet-704	428	12	terms	term	NOUN
admet-704	428	13	and	and	CCONJ
admet-704	428	14	conditions	condition	NOUN
admet-704	428	15	of	of	ADP
admet-704	428	16	the	the	DET
admet-704	428	17	creative	creative	ADJ
admet-704	428	18	commons	common	NOUN
admet-704	428	19	attribution	attribution	NOUN
admet-704	428	20	license	license	NOUN
admet-704	428	21	(	(	PUNCT
admet-704	428	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-704	428	23	)	)	PUNCT
admet-704	428	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN