id	sid	tid	token	lemma	pos
admet-733	1	1	biophysical	biophysical	ADJ
admet-733	1	2	methods	method	NOUN
admet-733	1	3	in	in	ADP
admet-733	1	4	early	early	ADJ
admet-733	1	5	drug	drug	NOUN
admet-733	1	6	discovery	discovery	NOUN
admet-733	1	7	doi	doi	PROPN
admet-733	1	8	:	:	PUNCT
admet-733	1	9	10.5599	10.5599	NUM
admet-733	1	10	/	/	SYM
admet-733	1	11	admet.733	admet.733	ADJ
admet-733	1	12	222	222	NUM
admet-733	1	13	admet	admet	NOUN
admet-733	1	14	&	&	CCONJ
admet-733	1	15	dmpk	dmpk	PROPN
admet-733	1	16	7(4	7(4	NUM
admet-733	1	17	)	)	PUNCT
admet-733	1	18	(	(	PUNCT
admet-733	1	19	2019	2019	NUM
admet-733	1	20	)	)	PUNCT
admet-733	1	21	222	222	NUM
admet-733	1	22	-	-	SYM
admet-733	1	23	241	241	NUM
admet-733	1	24	;	;	PUNCT
admet-733	1	25	doi	doi	NOUN
admet-733	1	26	:	:	PUNCT
admet-733	1	27	http://dx.doi.org/10.5599/admet.733	http://dx.doi.org/10.5599/admet.733	X
admet-733	1	28	open	open	ADJ
admet-733	1	29	access	access	NOUN
admet-733	1	30	:	:	PUNCT
admet-733	1	31	issn	issn	PROPN
admet-733	1	32	:	:	PUNCT
admet-733	1	33	1848	1848	NUM
admet-733	1	34	-	-	SYM
admet-733	1	35	7718	7718	NUM
admet-733	1	36	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-733	1	37	review	review	NOUN
admet-733	1	38	biophysical	biophysical	ADJ
admet-733	1	39	methods	method	NOUN
admet-733	1	40	in	in	ADP
admet-733	1	41	early	early	ADJ
admet-733	1	42	drug	drug	NOUN
admet-733	1	43	discovery	discovery	NOUN
admet-733	1	44	geoffrey	geoffrey	PROPN
admet-733	1	45	holdgate*1	holdgate*1	ADV
admet-733	1	46	,	,	PUNCT
admet-733	1	47	kevin	kevin	PROPN
admet-733	1	48	embrey2	embrey2	PROPN
admet-733	1	49	,	,	PUNCT
admet-733	1	50	alexander	alexander	PROPN
admet-733	1	51	milbradt2	milbradt2	PROPN
admet-733	1	52	and	and	CCONJ
admet-733	1	53	gareth	gareth	PROPN
admet-733	1	54	davies1	davies1	PROPN
admet-733	1	55	1	1	NUM
admet-733	1	56	hit	hit	VERB
admet-733	1	57	discovery	discovery	NOUN
admet-733	1	58	,	,	PUNCT
admet-733	1	59	discovery	discovery	NOUN
admet-733	1	60	sciences	sciences	PROPN
admet-733	1	61	,	,	PUNCT
admet-733	1	62	r&d	r&d	NOUN
admet-733	1	63	,	,	PUNCT
admet-733	1	64	astrazeneca	astrazeneca	PROPN
admet-733	1	65	,	,	PUNCT
admet-733	1	66	alderley	alderley	NOUN
admet-733	1	67	park	park	NOUN
admet-733	1	68	,	,	PUNCT
admet-733	1	69	uk	uk	PROPN
admet-733	1	70	2	2	NUM
admet-733	1	71	structure	structure	NOUN
admet-733	1	72	,	,	PUNCT
admet-733	1	73	biophysics	biophysic	NOUN
admet-733	1	74	and	and	CCONJ
admet-733	1	75	fblg	fblg	NOUN
admet-733	1	76	,	,	PUNCT
admet-733	1	77	discovery	discovery	NOUN
admet-733	1	78	sciences	sciences	PROPN
admet-733	1	79	,	,	PUNCT
admet-733	1	80	r&d	r&d	NOUN
admet-733	1	81	,	,	PUNCT
admet-733	1	82	astrazeneca	astrazeneca	PROPN
admet-733	1	83	,	,	PUNCT
admet-733	1	84	cambridge	cambridge	PROPN
admet-733	1	85	,	,	PUNCT
admet-733	1	86	uk	uk	PROPN
admet-733	1	87	*	*	PUNCT
admet-733	1	88	corresponding	correspond	VERB
admet-733	1	89	author	author	NOUN
admet-733	1	90	:	:	PUNCT
admet-733	1	91	e-mail:geoff.holdgate@astrazeneca.com	e-mail:geoff.holdgate@astrazeneca.com	NOUN
admet-733	1	92	;	;	PUNCT
admet-733	1	93	tel	tel	PROPN
admet-733	1	94	.	.	PUNCT
admet-733	1	95	:	:	PUNCT
admet-733	2	1	+44	+44	PROPN
admet-733	2	2	(	(	PUNCT
admet-733	2	3	0)1625	0)1625	NOUN
admet-733	2	4	234218	234218	NUM
admet-733	2	5	received	receive	VERB
admet-733	2	6	:	:	PUNCT
admet-733	2	7	september	september	PROPN
admet-733	2	8	30	30	NUM
admet-733	2	9	,	,	PUNCT
admet-733	2	10	2019	2019	NUM
admet-733	2	11	;	;	PUNCT
admet-733	2	12	revised	revise	VERB
admet-733	2	13	:	:	PUNCT
admet-733	2	14	november	november	PROPN
admet-733	2	15	19	19	NUM
admet-733	2	16	,	,	PUNCT
admet-733	2	17	2019	2019	NUM
admet-733	2	18	;	;	PUNCT
admet-733	2	19	published	publish	VERB
admet-733	2	20	:	:	PUNCT
admet-733	2	21	december	december	PROPN
admet-733	2	22	11	11	NUM
admet-733	2	23	,	,	PUNCT
admet-733	2	24	2019	2019	NUM
admet-733	2	25	abstract	abstract	ADJ
admet-733	2	26	biophysical	biophysical	ADJ
admet-733	2	27	methods	method	NOUN
admet-733	2	28	such	such	ADJ
admet-733	2	29	as	as	ADP
admet-733	2	30	mass	mass	ADJ
admet-733	2	31	spectrometry	spectrometry	NOUN
admet-733	2	32	,	,	PUNCT
admet-733	2	33	surface	surface	NOUN
admet-733	2	34	plasmon	plasmon	ADJ
admet-733	2	35	resonance	resonance	NOUN
admet-733	2	36	,	,	PUNCT
admet-733	2	37	nuclear	nuclear	ADJ
admet-733	2	38	magnetic	magnetic	ADJ
admet-733	2	39	resonance	resonance	NOUN
admet-733	2	40	,	,	PUNCT
admet-733	2	41	and	and	CCONJ
admet-733	2	42	both	both	DET
admet-733	2	43	differential	differential	NOUN
admet-733	2	44	scanning	scan	VERB
admet-733	2	45	isothermal	isothermal	ADJ
admet-733	2	46	titration	titration	NOUN
admet-733	2	47	calorimetry	calorimetry	NOUN
admet-733	2	48	are	be	AUX
admet-733	2	49	now	now	ADV
admet-733	2	50	well	well	ADV
admet-733	2	51	established	establish	VERB
admet-733	2	52	as	as	ADP
admet-733	2	53	key	key	ADJ
admet-733	2	54	components	component	NOUN
admet-733	2	55	of	of	ADP
admet-733	2	56	the	the	DET
admet-733	2	57	early	early	ADJ
admet-733	2	58	drug	drug	NOUN
admet-733	2	59	discovery	discovery	NOUN
admet-733	2	60	process	process	NOUN
admet-733	2	61	.	.	PUNCT
admet-733	3	1	these	these	DET
admet-733	3	2	approaches	approach	NOUN
admet-733	3	3	are	be	AUX
admet-733	3	4	used	use	VERB
admet-733	3	5	successfully	successfully	ADV
admet-733	3	6	for	for	ADP
admet-733	3	7	a	a	DET
admet-733	3	8	range	range	NOUN
admet-733	3	9	of	of	ADP
admet-733	3	10	activities	activity	NOUN
admet-733	3	11	,	,	PUNCT
admet-733	3	12	including	include	VERB
admet-733	3	13	assay	assay	NOUN
admet-733	3	14	development	development	NOUN
admet-733	3	15	,	,	PUNCT
admet-733	3	16	primary	primary	ADJ
admet-733	3	17	screening	screening	NOUN
admet-733	3	18	,	,	PUNCT
admet-733	3	19	hit	hit	VERB
admet-733	3	20	confirmation	confirmation	NOUN
admet-733	3	21	and	and	CCONJ
admet-733	3	22	detailed	detailed	ADJ
admet-733	3	23	mechanistic	mechanistic	ADJ
admet-733	3	24	characterisation	characterisation	NOUN
admet-733	3	25	of	of	ADP
admet-733	3	26	compound	compound	NOUN
admet-733	3	27	binding	bind	VERB
admet-733	3	28	.	.	PUNCT
admet-733	4	1	matching	match	VERB
admet-733	4	2	the	the	DET
admet-733	4	3	speed	speed	NOUN
admet-733	4	4	,	,	PUNCT
admet-733	4	5	sensitivity	sensitivity	NOUN
admet-733	4	6	and	and	CCONJ
admet-733	4	7	information	information	NOUN
admet-733	4	8	content	content	NOUN
admet-733	4	9	of	of	ADP
admet-733	4	10	the	the	DET
admet-733	4	11	various	various	ADJ
admet-733	4	12	techniques	technique	NOUN
admet-733	4	13	to	to	ADP
admet-733	4	14	the	the	DET
admet-733	4	15	generation	generation	NOUN
admet-733	4	16	of	of	ADP
admet-733	4	17	critical	critical	ADJ
admet-733	4	18	data	datum	NOUN
admet-733	4	19	and	and	CCONJ
admet-733	4	20	information	information	NOUN
admet-733	4	21	required	require	VERB
admet-733	4	22	at	at	ADP
admet-733	4	23	each	each	DET
admet-733	4	24	phase	phase	NOUN
admet-733	4	25	of	of	ADP
admet-733	4	26	the	the	DET
admet-733	4	27	drug	drug	NOUN
admet-733	4	28	discovery	discovery	NOUN
admet-733	4	29	process	process	NOUN
admet-733	4	30	has	have	AUX
admet-733	4	31	been	be	AUX
admet-733	4	32	key	key	ADJ
admet-733	4	33	.	.	PUNCT
admet-733	5	1	this	this	DET
admet-733	5	2	review	review	NOUN
admet-733	5	3	describes	describe	VERB
admet-733	5	4	the	the	DET
admet-733	5	5	framework	framework	NOUN
admet-733	5	6	by	by	ADP
admet-733	5	7	which	which	PRON
admet-733	5	8	these	these	DET
admet-733	5	9	methods	method	NOUN
admet-733	5	10	have	have	AUX
admet-733	5	11	been	be	AUX
admet-733	5	12	applied	apply	VERB
admet-733	5	13	in	in	ADP
admet-733	5	14	the	the	DET
admet-733	5	15	drug	drug	NOUN
admet-733	5	16	discovery	discovery	NOUN
admet-733	5	17	process	process	NOUN
admet-733	5	18	and	and	CCONJ
admet-733	5	19	provides	provide	VERB
admet-733	5	20	case	case	NOUN
admet-733	5	21	studies	study	NOUN
admet-733	5	22	to	to	PART
admet-733	5	23	exemplify	exemplify	VERB
admet-733	5	24	the	the	DET
admet-733	5	25	impact	impact	NOUN
admet-733	5	26	.	.	PUNCT
admet-733	6	1	keywords	keyword	NOUN
admet-733	6	2	affinity	affinity	NOUN
admet-733	6	3	selection	selection	NOUN
admet-733	6	4	mass	mass	NOUN
admet-733	6	5	spectrometry	spectrometry	NOUN
admet-733	6	6	;	;	PUNCT
admet-733	6	7	surface	surface	NOUN
admet-733	6	8	plasmon	plasmon	NOUN
admet-733	6	9	resonance	resonance	NOUN
admet-733	6	10	;	;	PUNCT
admet-733	6	11	nuclear	nuclear	ADJ
admet-733	6	12	magnetic	magnetic	ADJ
admet-733	6	13	resonance	resonance	NOUN
admet-733	6	14	;	;	PUNCT
admet-733	6	15	differential	differential	NOUN
admet-733	6	16	scanning	scanning	NOUN
admet-733	6	17	fluorimetry	fluorimetry	NOUN
admet-733	6	18	;	;	PUNCT
admet-733	6	19	isothermal	isothermal	ADJ
admet-733	6	20	titration	titration	NOUN
admet-733	6	21	calorimetry	calorimetry	NOUN
admet-733	6	22	;	;	PUNCT
admet-733	6	23	microscale	microscale	ADJ
admet-733	6	24	thermophoresis	thermophoresis	NOUN
admet-733	6	25	introduction	introduction	NOUN
admet-733	6	26	biophysical	biophysical	ADJ
admet-733	6	27	methods	method	NOUN
admet-733	6	28	,	,	PUNCT
admet-733	6	29	which	which	PRON
admet-733	6	30	can	can	AUX
admet-733	6	31	encompass	encompass	VERB
admet-733	6	32	a	a	DET
admet-733	6	33	wide	wide	ADJ
admet-733	6	34	range	range	NOUN
admet-733	6	35	of	of	ADP
admet-733	6	36	techniques	technique	NOUN
admet-733	6	37	focussed	focusse	VERB
admet-733	6	38	on	on	ADP
admet-733	6	39	measuring	measure	VERB
admet-733	6	40	the	the	DET
admet-733	6	41	structure	structure	NOUN
admet-733	6	42	,	,	PUNCT
admet-733	6	43	properties	property	NOUN
admet-733	6	44	,	,	PUNCT
admet-733	6	45	dynamics	dynamic	NOUN
admet-733	6	46	or	or	CCONJ
admet-733	6	47	function	function	NOUN
admet-733	6	48	of	of	ADP
admet-733	6	49	biomolecules	biomolecule	NOUN
admet-733	6	50	,	,	PUNCT
admet-733	6	51	have	have	AUX
admet-733	6	52	been	be	AUX
admet-733	6	53	increasingly	increasingly	ADV
admet-733	6	54	employed	employ	VERB
admet-733	6	55	in	in	ADP
admet-733	6	56	the	the	DET
admet-733	6	57	drug	drug	NOUN
admet-733	6	58	discovery	discovery	NOUN
admet-733	6	59	process	process	NOUN
admet-733	6	60	since	since	SCONJ
admet-733	6	61	their	their	PRON
admet-733	6	62	first	first	ADJ
admet-733	6	63	introduction	introduction	NOUN
admet-733	6	64	in	in	ADP
admet-733	6	65	the	the	DET
admet-733	6	66	early	early	ADJ
admet-733	6	67	1990s	1990	NOUN
admet-733	6	68	.	.	PUNCT
admet-733	7	1	it	it	PRON
admet-733	7	2	was	be	AUX
admet-733	7	3	during	during	ADP
admet-733	7	4	this	this	DET
admet-733	7	5	time	time	NOUN
admet-733	7	6	that	that	SCONJ
admet-733	7	7	commercial	commercial	ADJ
admet-733	7	8	instruments	instrument	NOUN
admet-733	7	9	such	such	ADJ
admet-733	7	10	as	as	ADP
admet-733	7	11	the	the	DET
admet-733	7	12	first	first	ADJ
admet-733	7	13	isothermal	isothermal	ADJ
admet-733	7	14	titration	titration	NOUN
admet-733	7	15	calorimeter	calorimeter	NOUN
admet-733	7	16	(	(	PUNCT
admet-733	7	17	itc	itc	PROPN
admet-733	7	18	)	)	PUNCT
admet-733	8	1	[	[	X
admet-733	8	2	1	1	X
admet-733	8	3	]	]	PUNCT
admet-733	8	4	and	and	CCONJ
admet-733	8	5	the	the	DET
admet-733	8	6	first	first	ADJ
admet-733	8	7	surface	surface	NOUN
admet-733	8	8	plasmon	plasmon	NOUN
admet-733	8	9	resonance	resonance	NOUN
admet-733	8	10	(	(	PUNCT
admet-733	8	11	spr	spr	INTJ
admet-733	8	12	)	)	PUNCT
admet-733	8	13	[	[	X
admet-733	8	14	2	2	NUM
admet-733	8	15	]	]	PUNCT
admet-733	8	16	instruments	instrument	NOUN
admet-733	8	17	became	become	VERB
admet-733	8	18	available	available	ADJ
admet-733	8	19	and	and	CCONJ
admet-733	8	20	their	their	PRON
admet-733	8	21	use	use	NOUN
admet-733	8	22	exemplified	exemplify	VERB
admet-733	8	23	using	use	VERB
admet-733	8	24	biochemical	biochemical	ADJ
admet-733	8	25	systems	system	NOUN
admet-733	8	26	.	.	PUNCT
admet-733	9	1	alongside	alongside	ADP
admet-733	9	2	this	this	PRON
admet-733	9	3	,	,	PUNCT
admet-733	9	4	existing	exist	VERB
admet-733	9	5	biophysical	biophysical	ADJ
admet-733	9	6	approaches	approach	NOUN
admet-733	9	7	were	be	AUX
admet-733	9	8	used	use	VERB
admet-733	9	9	in	in	ADP
admet-733	9	10	novel	novel	ADJ
admet-733	9	11	ways	way	NOUN
admet-733	9	12	to	to	PART
admet-733	9	13	identify	identify	VERB
admet-733	9	14	and	and	CCONJ
admet-733	9	15	characterise	characterise	VERB
admet-733	9	16	protein	protein	NOUN
admet-733	9	17	-	-	PUNCT
admet-733	9	18	ligand	ligand	NOUN
admet-733	9	19	interactions	interaction	NOUN
admet-733	9	20	,	,	PUNCT
admet-733	9	21	for	for	ADP
admet-733	9	22	example	example	NOUN
admet-733	9	23	the	the	DET
admet-733	9	24	first	first	ADJ
admet-733	9	25	report	report	NOUN
admet-733	9	26	of	of	ADP
admet-733	9	27	the	the	DET
admet-733	9	28	use	use	NOUN
admet-733	9	29	of	of	ADP
admet-733	9	30	affinity	affinity	NOUN
admet-733	9	31	selection	selection	NOUN
admet-733	9	32	,	,	PUNCT
admet-733	9	33	coupled	couple	VERB
admet-733	9	34	to	to	ADP
admet-733	9	35	detection	detection	NOUN
admet-733	9	36	by	by	ADP
admet-733	9	37	mass	mass	ADJ
admet-733	9	38	spectrometry	spectrometry	NOUN
admet-733	9	39	,	,	PUNCT
admet-733	9	40	for	for	ADP
admet-733	9	41	the	the	DET
admet-733	9	42	identification	identification	NOUN
admet-733	9	43	of	of	ADP
admet-733	9	44	molecules	molecule	NOUN
admet-733	9	45	binding	bind	VERB
admet-733	9	46	to	to	ADP
admet-733	9	47	a	a	DET
admet-733	9	48	macromolecule	macromolecule	NOUN
admet-733	9	49	[	[	X
admet-733	9	50	3	3	NUM
admet-733	9	51	]	]	PUNCT
admet-733	9	52	,	,	PUNCT
admet-733	9	53	and	and	CCONJ
admet-733	9	54	the	the	DET
admet-733	9	55	use	use	NOUN
admet-733	9	56	of	of	ADP
admet-733	9	57	nuclear	nuclear	ADJ
admet-733	9	58	magnetic	magnetic	ADJ
admet-733	9	59	resonance	resonance	NOUN
admet-733	9	60	(	(	PUNCT
admet-733	9	61	nmr	nmr	NOUN
admet-733	9	62	)	)	PUNCT
admet-733	9	63	to	to	PART
admet-733	9	64	identify	identify	VERB
admet-733	9	65	fragments	fragment	NOUN
admet-733	9	66	that	that	PRON
admet-733	9	67	could	could	AUX
admet-733	9	68	subsequently	subsequently	ADV
admet-733	9	69	be	be	AUX
admet-733	9	70	optimised	optimise	VERB
admet-733	9	71	and	and	CCONJ
admet-733	9	72	linked	link	VERB
admet-733	9	73	to	to	PART
admet-733	9	74	form	form	VERB
admet-733	9	75	more	more	ADV
admet-733	9	76	potent	potent	ADJ
admet-733	9	77	compounds	compound	NOUN
admet-733	9	78	[	[	X
admet-733	9	79	4	4	NUM
admet-733	9	80	]	]	PUNCT
admet-733	9	81	.	.	PUNCT
admet-733	10	1	the	the	DET
admet-733	10	2	development	development	NOUN
admet-733	10	3	of	of	ADP
admet-733	10	4	these	these	DET
admet-733	10	5	biophysical	biophysical	ADJ
admet-733	10	6	methods	method	NOUN
admet-733	10	7	coincided	coincide	VERB
admet-733	10	8	with	with	ADP
admet-733	10	9	the	the	DET
admet-733	10	10	advent	advent	NOUN
admet-733	10	11	of	of	ADP
admet-733	10	12	high	high	ADJ
admet-733	10	13	-	-	PUNCT
admet-733	10	14	throughput	throughput	NOUN
admet-733	10	15	screening	screening	NOUN
admet-733	10	16	(	(	PUNCT
admet-733	10	17	hts	hts	PROPN
admet-733	10	18	)	)	PUNCT
admet-733	10	19	,	,	PUNCT
admet-733	10	20	leading	lead	VERB
admet-733	10	21	from	from	ADP
admet-733	10	22	natural	natural	ADJ
admet-733	10	23	product	product	NOUN
admet-733	10	24	screening	screening	NOUN
admet-733	10	25	of	of	ADP
admet-733	10	26	a	a	DET
admet-733	10	27	few	few	ADJ
admet-733	10	28	hundred	hundred	NUM
admet-733	10	29	compounds	compound	NOUN
admet-733	10	30	each	each	DET
admet-733	10	31	week	week	NOUN
admet-733	10	32	in	in	ADP
admet-733	10	33	the	the	DET
admet-733	10	34	late	late	ADJ
admet-733	10	35	1980s	1980	NOUN
admet-733	10	36	,	,	PUNCT
admet-733	10	37	through	through	ADP
admet-733	10	38	to	to	ADP
admet-733	10	39	hts	hts	PROPN
admet-733	10	40	hits	hit	NOUN
admet-733	10	41	being	be	AUX
admet-733	10	42	responsible	responsible	ADJ
admet-733	10	43	for	for	ADP
admet-733	10	44	starting	start	VERB
admet-733	10	45	matter	matter	NOUN
admet-733	10	46	for	for	ADP
admet-733	10	47	almost	almost	ADV
admet-733	10	48	half	half	NOUN
admet-733	10	49	of	of	ADP
admet-733	10	50	drug	drug	NOUN
admet-733	10	51	companies	company	NOUN
admet-733	10	52	’	’	PART
admet-733	10	53	portfolios	portfolio	NOUN
admet-733	10	54	in	in	ADP
admet-733	10	55	the	the	DET
admet-733	10	56	mid-1990s	mid-1990	NOUN
admet-733	10	57	[	[	X
admet-733	10	58	5,6	5,6	NUM
admet-733	10	59	]	]	PUNCT
admet-733	10	60	.	.	PUNCT
admet-733	11	1	this	this	PRON
admet-733	11	2	allowed	allow	VERB
admet-733	11	3	the	the	DET
admet-733	11	4	valuable	valuable	ADJ
admet-733	11	5	combination	combination	NOUN
admet-733	11	6	of	of	ADP
admet-733	11	7	biophysics	biophysic	NOUN
admet-733	11	8	with	with	ADP
admet-733	11	9	hts	ht	NOUN
admet-733	11	10	to	to	PART
admet-733	11	11	contribute	contribute	VERB
admet-733	11	12	to	to	ADP
admet-733	11	13	the	the	DET
admet-733	11	14	establishment	establishment	NOUN
admet-733	11	15	of	of	ADP
admet-733	11	16	high	high	ADJ
admet-733	11	17	quality	quality	NOUN
admet-733	11	18	,	,	PUNCT
admet-733	11	19	high	high	ADJ
admet-733	11	20	-	-	PUNCT
admet-733	11	21	throughput	throughput	NOUN
admet-733	11	22	assays	assay	NOUN
admet-733	11	23	through	through	ADP
admet-733	11	24	the	the	DET
admet-733	11	25	characterisation	characterisation	NOUN
admet-733	11	26	of	of	ADP
admet-733	11	27	protein	protein	NOUN
admet-733	11	28	and	and	CCONJ
admet-733	11	29	tool	tool	NOUN
admet-733	11	30	ligands	ligand	NOUN
admet-733	11	31	,	,	PUNCT
admet-733	11	32	as	as	ADV
admet-733	11	33	well	well	ADV
admet-733	11	34	as	as	ADP
admet-733	11	35	the	the	DET
admet-733	11	36	evaluation	evaluation	NOUN
admet-733	11	37	of	of	ADP
admet-733	11	38	hts	hts	PROPN
admet-733	11	39	output	output	NOUN
admet-733	11	40	through	through	ADP
admet-733	11	41	orthogonal	orthogonal	ADJ
admet-733	11	42	application	application	NOUN
admet-733	11	43	of	of	ADP
admet-733	11	44	biophysical	biophysical	ADJ
admet-733	11	45	methods	method	NOUN
admet-733	11	46	to	to	PART
admet-733	11	47	screen	screen	VERB
admet-733	11	48	for	for	ADP
admet-733	11	49	true	true	ADJ
admet-733	11	50	target	target	NOUN
admet-733	11	51	engagement	engagement	NOUN
admet-733	11	52	[	[	X
admet-733	11	53	7	7	NUM
admet-733	11	54	]	]	PUNCT
admet-733	11	55	.	.	PUNCT
admet-733	12	1	more	more	ADV
admet-733	12	2	recently	recently	ADV
admet-733	12	3	,	,	PUNCT
admet-733	12	4	biophysical	biophysical	ADJ
admet-733	12	5	http://dx.doi.org/10.5599/admet.733	http://dx.doi.org/10.5599/admet.733	ADJ
admet-733	12	6	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-733	12	7	admet	admet	PROPN
admet-733	12	8	&	&	CCONJ
admet-733	12	9	dmpk	dmpk	PROPN
admet-733	12	10	7(4	7(4	NUM
admet-733	12	11	)	)	PUNCT
admet-733	12	12	(	(	PUNCT
admet-733	12	13	2019	2019	NUM
admet-733	12	14	)	)	PUNCT
admet-733	12	15	222	222	NUM
admet-733	12	16	-	-	PUNCT
admet-733	12	17	241	241	NUM
admet-733	12	18	biophysical	biophysical	ADJ
admet-733	12	19	methods	method	NOUN
admet-733	12	20	in	in	ADP
admet-733	12	21	early	early	ADJ
admet-733	12	22	drug	drug	NOUN
admet-733	12	23	discovery	discovery	NOUN
admet-733	12	24	doi	doi	PROPN
admet-733	12	25	:	:	PUNCT
admet-733	12	26	10.5599	10.5599	NUM
admet-733	12	27	/	/	SYM
admet-733	12	28	admet.733	admet.733	ADJ
admet-733	12	29	223	223	NUM
admet-733	12	30	methods	method	NOUN
admet-733	12	31	have	have	AUX
admet-733	12	32	matured	mature	VERB
admet-733	12	33	,	,	PUNCT
admet-733	12	34	throughput	throughput	NOUN
admet-733	12	35	has	have	AUX
admet-733	12	36	increased	increase	VERB
admet-733	12	37	,	,	PUNCT
admet-733	12	38	and	and	CCONJ
admet-733	12	39	sensitivity	sensitivity	NOUN
admet-733	12	40	improved	improve	VERB
admet-733	12	41	,	,	PUNCT
admet-733	12	42	such	such	ADJ
admet-733	12	43	that	that	SCONJ
admet-733	12	44	some	some	PRON
admet-733	12	45	of	of	ADP
admet-733	12	46	these	these	DET
admet-733	12	47	methods	method	NOUN
admet-733	12	48	can	can	AUX
admet-733	12	49	also	also	ADV
admet-733	12	50	now	now	ADV
admet-733	12	51	be	be	AUX
admet-733	12	52	employed	employ	VERB
admet-733	12	53	in	in	ADP
admet-733	12	54	primary	primary	ADJ
admet-733	12	55	screening	screening	NOUN
admet-733	12	56	,	,	PUNCT
admet-733	12	57	not	not	PART
admet-733	12	58	only	only	ADV
admet-733	12	59	for	for	ADP
admet-733	12	60	fragments	fragment	NOUN
admet-733	12	61	,	,	PUNCT
admet-733	12	62	which	which	PRON
admet-733	12	63	typically	typically	ADV
admet-733	12	64	screen	screen	VERB
admet-733	12	65	lower	low	ADJ
admet-733	12	66	numbers	number	NOUN
admet-733	12	67	of	of	ADP
admet-733	12	68	low	low	ADJ
admet-733	12	69	molecular	molecular	ADJ
admet-733	12	70	weight	weight	NOUN
admet-733	12	71	compounds	compound	NOUN
admet-733	12	72	[	[	X
admet-733	12	73	8	8	NUM
admet-733	12	74	]	]	PUNCT
admet-733	12	75	,	,	PUNCT
admet-733	12	76	but	but	CCONJ
admet-733	12	77	for	for	ADP
admet-733	12	78	screening	screen	VERB
admet-733	12	79	libraries	library	NOUN
admet-733	12	80	comprising	comprise	VERB
admet-733	12	81	many	many	ADJ
admet-733	12	82	thousands	thousand	NOUN
admet-733	12	83	of	of	ADP
admet-733	12	84	compounds	compound	NOUN
admet-733	12	85	[	[	X
admet-733	12	86	9	9	NUM
admet-733	12	87	]	]	PUNCT
admet-733	12	88	.	.	PUNCT
admet-733	13	1	the	the	DET
admet-733	13	2	high	high	ADJ
admet-733	13	3	-	-	PUNCT
admet-733	13	4	fidelity	fidelity	NOUN
admet-733	13	5	nature	nature	NOUN
admet-733	13	6	of	of	ADP
admet-733	13	7	many	many	ADJ
admet-733	13	8	biophysical	biophysical	ADJ
admet-733	13	9	methods	method	NOUN
admet-733	13	10	,	,	PUNCT
admet-733	13	11	coupled	couple	VERB
admet-733	13	12	to	to	ADP
admet-733	13	13	the	the	DET
admet-733	13	14	specific	specific	ADJ
admet-733	13	15	information	information	NOUN
admet-733	13	16	content	content	NOUN
admet-733	13	17	they	they	PRON
admet-733	13	18	can	can	AUX
admet-733	13	19	access	access	VERB
admet-733	13	20	,	,	PUNCT
admet-733	13	21	has	have	AUX
admet-733	13	22	also	also	ADV
admet-733	13	23	meant	mean	VERB
admet-733	13	24	that	that	SCONJ
admet-733	13	25	they	they	PRON
admet-733	13	26	are	be	AUX
admet-733	13	27	used	use	VERB
admet-733	13	28	increasingly	increasingly	ADV
admet-733	13	29	to	to	PART
admet-733	13	30	characterise	characterise	VERB
admet-733	13	31	the	the	DET
admet-733	13	32	mode	mode	NOUN
admet-733	13	33	of	of	ADP
admet-733	13	34	action	action	NOUN
admet-733	13	35	of	of	ADP
admet-733	13	36	hits	hit	NOUN
admet-733	13	37	and	and	CCONJ
admet-733	13	38	leads	lead	NOUN
admet-733	13	39	.	.	PUNCT
admet-733	14	1	some	some	DET
admet-733	14	2	methods	method	NOUN
admet-733	14	3	provide	provide	VERB
admet-733	14	4	access	access	NOUN
admet-733	14	5	to	to	ADP
admet-733	14	6	kinetic	kinetic	ADJ
admet-733	14	7	data	datum	NOUN
admet-733	14	8	[	[	X
admet-733	14	9	10	10	NUM
admet-733	14	10	]	]	PUNCT
admet-733	14	11	,	,	PUNCT
admet-733	14	12	whilst	whilst	SCONJ
admet-733	14	13	others	other	NOUN
admet-733	14	14	enable	enable	VERB
admet-733	14	15	thermodynamic	thermodynamic	ADJ
admet-733	14	16	characterisation	characterisation	NOUN
admet-733	14	17	of	of	ADP
admet-733	14	18	ligand	ligand	ADJ
admet-733	14	19	binding	bind	VERB
admet-733	15	1	[	[	X
admet-733	15	2	11	11	NUM
admet-733	15	3	]	]	PUNCT
admet-733	15	4	.	.	PUNCT
admet-733	16	1	others	other	NOUN
admet-733	16	2	may	may	AUX
admet-733	16	3	allow	allow	VERB
admet-733	16	4	structural	structural	ADJ
admet-733	16	5	insights	insight	NOUN
admet-733	16	6	into	into	ADP
admet-733	16	7	binding	binding	ADJ
admet-733	16	8	mode	mode	NOUN
admet-733	16	9	and	and	CCONJ
admet-733	16	10	binding	bind	VERB
admet-733	16	11	site	site	NOUN
admet-733	16	12	[	[	X
admet-733	16	13	12,13	12,13	NUM
admet-733	16	14	]	]	PUNCT
admet-733	16	15	.	.	PUNCT
admet-733	17	1	our	our	PRON
admet-733	17	2	understanding	understanding	NOUN
admet-733	17	3	of	of	ADP
admet-733	17	4	the	the	DET
admet-733	17	5	strengths	strength	NOUN
admet-733	17	6	and	and	CCONJ
admet-733	17	7	weaknesses	weakness	NOUN
admet-733	17	8	of	of	ADP
admet-733	17	9	the	the	DET
admet-733	17	10	methods	method	NOUN
admet-733	17	11	,	,	PUNCT
admet-733	17	12	as	as	ADV
admet-733	17	13	well	well	ADV
admet-733	17	14	as	as	ADP
admet-733	17	15	a	a	DET
admet-733	17	16	better	well	ADJ
admet-733	17	17	appreciation	appreciation	NOUN
admet-733	17	18	of	of	ADP
admet-733	17	19	the	the	DET
admet-733	17	20	impact	impact	NOUN
admet-733	17	21	that	that	PRON
admet-733	17	22	results	result	VERB
admet-733	17	23	from	from	ADP
admet-733	17	24	appropriate	appropriate	ADJ
admet-733	17	25	positioning	positioning	NOUN
admet-733	17	26	within	within	ADP
admet-733	17	27	the	the	DET
admet-733	17	28	drug	drug	NOUN
admet-733	17	29	discovery	discovery	NOUN
admet-733	17	30	process	process	NOUN
admet-733	17	31	has	have	AUX
admet-733	17	32	contributed	contribute	VERB
admet-733	17	33	significantly	significantly	ADV
admet-733	17	34	to	to	ADP
admet-733	17	35	the	the	DET
admet-733	17	36	increased	increase	VERB
admet-733	17	37	use	use	NOUN
admet-733	17	38	of	of	ADP
admet-733	17	39	biophysical	biophysical	ADJ
admet-733	17	40	methods	method	NOUN
admet-733	17	41	observed	observe	VERB
admet-733	17	42	today	today	NOUN
admet-733	17	43	.	.	PUNCT
admet-733	18	1	this	this	DET
admet-733	18	2	review	review	NOUN
admet-733	18	3	will	will	AUX
admet-733	18	4	provide	provide	VERB
admet-733	18	5	an	an	DET
admet-733	18	6	overview	overview	NOUN
admet-733	18	7	of	of	ADP
admet-733	18	8	the	the	DET
admet-733	18	9	benefit	benefit	NOUN
admet-733	18	10	that	that	PRON
admet-733	18	11	can	can	AUX
admet-733	18	12	be	be	AUX
admet-733	18	13	gained	gain	VERB
admet-733	18	14	from	from	ADP
admet-733	18	15	the	the	DET
admet-733	18	16	incorporation	incorporation	NOUN
admet-733	18	17	of	of	ADP
admet-733	18	18	biophysical	biophysical	ADJ
admet-733	18	19	methods	method	NOUN
admet-733	18	20	within	within	ADP
admet-733	18	21	areas	area	NOUN
admet-733	18	22	of	of	ADP
admet-733	18	23	the	the	DET
admet-733	18	24	drug	drug	NOUN
admet-733	18	25	discovery	discovery	NOUN
admet-733	18	26	process	process	NOUN
admet-733	18	27	and	and	CCONJ
admet-733	18	28	will	will	AUX
admet-733	18	29	provide	provide	VERB
admet-733	18	30	case	case	NOUN
admet-733	18	31	studies	study	NOUN
admet-733	18	32	to	to	PART
admet-733	18	33	exemplify	exemplify	VERB
admet-733	18	34	their	their	PRON
admet-733	18	35	impact	impact	NOUN
admet-733	18	36	.	.	PUNCT
admet-733	19	1	assay	assay	PROPN
admet-733	19	2	development	development	NOUN
admet-733	19	3	the	the	DET
admet-733	19	4	capability	capability	NOUN
admet-733	19	5	to	to	PART
admet-733	19	6	design	design	VERB
admet-733	19	7	,	,	PUNCT
admet-733	19	8	build	build	VERB
admet-733	19	9	and	and	CCONJ
admet-733	19	10	implement	implement	VERB
admet-733	19	11	assays	assay	NOUN
admet-733	19	12	that	that	PRON
admet-733	19	13	are	be	AUX
admet-733	19	14	specific	specific	ADJ
admet-733	19	15	,	,	PUNCT
admet-733	19	16	robust	robust	ADJ
admet-733	19	17	and	and	CCONJ
admet-733	19	18	sensitive	sensitive	ADJ
admet-733	19	19	enough	enough	ADV
admet-733	19	20	to	to	PART
admet-733	19	21	identify	identify	VERB
admet-733	19	22	and	and	CCONJ
admet-733	19	23	characterise	characterise	VERB
admet-733	19	24	potential	potential	ADJ
admet-733	19	25	new	new	ADJ
admet-733	19	26	drug	drug	NOUN
admet-733	19	27	molecules	molecule	NOUN
admet-733	19	28	is	be	AUX
admet-733	19	29	fundamental	fundamental	ADJ
admet-733	19	30	to	to	ADP
admet-733	19	31	drug	drug	NOUN
admet-733	19	32	discovery	discovery	NOUN
admet-733	19	33	.	.	PUNCT
admet-733	20	1	in	in	ADP
admet-733	20	2	developing	develop	VERB
admet-733	20	3	a	a	DET
admet-733	20	4	new	new	ADJ
admet-733	20	5	assay	assay	NOUN
admet-733	20	6	there	there	PRON
admet-733	20	7	are	be	VERB
admet-733	20	8	several	several	ADJ
admet-733	20	9	factors	factor	NOUN
admet-733	20	10	that	that	PRON
admet-733	20	11	must	must	AUX
admet-733	20	12	be	be	AUX
admet-733	20	13	considered	consider	VERB
admet-733	20	14	.	.	PUNCT
admet-733	21	1	these	these	PRON
admet-733	21	2	include	include	VERB
admet-733	21	3	:	:	PUNCT
admet-733	21	4	the	the	DET
admet-733	21	5	nature	nature	NOUN
admet-733	21	6	of	of	ADP
admet-733	21	7	the	the	DET
admet-733	21	8	reagents	reagent	NOUN
admet-733	21	9	,	,	PUNCT
admet-733	21	10	such	such	ADJ
admet-733	21	11	as	as	ADP
admet-733	21	12	their	their	PRON
admet-733	21	13	identity	identity	NOUN
admet-733	21	14	,	,	PUNCT
admet-733	21	15	purity	purity	NOUN
admet-733	21	16	,	,	PUNCT
admet-733	21	17	concentration	concentration	NOUN
admet-733	21	18	,	,	PUNCT
admet-733	21	19	functionality	functionality	NOUN
admet-733	21	20	and	and	CCONJ
admet-733	21	21	stability	stability	NOUN
admet-733	21	22	;	;	PUNCT
admet-733	21	23	the	the	DET
admet-733	21	24	features	feature	NOUN
admet-733	21	25	of	of	ADP
admet-733	21	26	the	the	DET
admet-733	21	27	detection	detection	NOUN
admet-733	21	28	system	system	NOUN
admet-733	21	29	,	,	PUNCT
admet-733	21	30	such	such	ADJ
admet-733	21	31	as	as	ADP
admet-733	21	32	the	the	DET
admet-733	21	33	sensitivity	sensitivity	NOUN
admet-733	21	34	,	,	PUNCT
admet-733	21	35	dynamic	dynamic	ADJ
admet-733	21	36	range	range	NOUN
admet-733	21	37	,	,	PUNCT
admet-733	21	38	potential	potential	NOUN
admet-733	21	39	for	for	ADP
admet-733	21	40	interference	interference	NOUN
admet-733	21	41	and	and	CCONJ
admet-733	21	42	reproducibility	reproducibility	NOUN
admet-733	21	43	;	;	PUNCT
admet-733	21	44	the	the	DET
admet-733	21	45	analysis	analysis	NOUN
admet-733	21	46	of	of	ADP
admet-733	21	47	the	the	DET
admet-733	21	48	data	datum	NOUN
admet-733	21	49	;	;	PUNCT
admet-733	21	50	and	and	CCONJ
admet-733	21	51	the	the	DET
admet-733	21	52	subsequent	subsequent	ADJ
admet-733	21	53	statistical	statistical	ADJ
admet-733	21	54	examination	examination	NOUN
admet-733	21	55	of	of	ADP
admet-733	21	56	assay	assay	ADJ
admet-733	21	57	performance	performance	NOUN
admet-733	21	58	.	.	PUNCT
admet-733	22	1	the	the	DET
admet-733	22	2	application	application	NOUN
admet-733	22	3	of	of	ADP
admet-733	22	4	biophysical	biophysical	ADJ
admet-733	22	5	methods	method	NOUN
admet-733	22	6	early	early	ADV
admet-733	22	7	during	during	ADP
admet-733	22	8	assay	assay	ADJ
admet-733	22	9	development	development	NOUN
admet-733	22	10	can	can	AUX
admet-733	22	11	help	help	VERB
admet-733	22	12	to	to	PART
admet-733	22	13	understand	understand	VERB
admet-733	22	14	some	some	PRON
admet-733	22	15	of	of	ADP
admet-733	22	16	these	these	DET
admet-733	22	17	features	feature	NOUN
admet-733	22	18	and	and	CCONJ
admet-733	22	19	to	to	PART
admet-733	22	20	ensure	ensure	VERB
admet-733	22	21	that	that	SCONJ
admet-733	22	22	high	high	ADJ
admet-733	22	23	-	-	PUNCT
admet-733	22	24	fidelity	fidelity	NOUN
admet-733	22	25	,	,	PUNCT
admet-733	22	26	fit	fit	ADJ
admet-733	22	27	for	for	ADP
admet-733	22	28	purpose	purpose	NOUN
admet-733	22	29	assays	assay	NOUN
admet-733	22	30	are	be	AUX
admet-733	22	31	developed	develop	VERB
admet-733	22	32	.	.	PUNCT
admet-733	23	1	of	of	ADP
admet-733	23	2	course	course	NOUN
admet-733	23	3	,	,	PUNCT
admet-733	23	4	this	this	DET
admet-733	23	5	extra	extra	ADJ
admet-733	23	6	resource	resource	NOUN
admet-733	23	7	needs	need	VERB
admet-733	23	8	to	to	PART
admet-733	23	9	be	be	AUX
admet-733	23	10	considered	consider	VERB
admet-733	23	11	during	during	ADP
admet-733	23	12	project	project	NOUN
admet-733	23	13	planning	planning	NOUN
admet-733	23	14	,	,	PUNCT
admet-733	23	15	but	but	CCONJ
admet-733	23	16	the	the	DET
admet-733	23	17	benefits	benefit	NOUN
admet-733	23	18	of	of	ADP
admet-733	23	19	applying	apply	VERB
admet-733	23	20	this	this	DET
admet-733	23	21	early	early	ADJ
admet-733	23	22	outweighs	outweigh	VERB
admet-733	23	23	the	the	DET
admet-733	23	24	resource	resource	NOUN
admet-733	23	25	that	that	PRON
admet-733	23	26	would	would	AUX
admet-733	23	27	need	need	VERB
admet-733	23	28	to	to	PART
admet-733	23	29	be	be	AUX
admet-733	23	30	applied	apply	VERB
admet-733	23	31	to	to	ADP
admet-733	23	32	rescue	rescue	NOUN
admet-733	23	33	projects	project	NOUN
admet-733	23	34	which	which	PRON
admet-733	23	35	have	have	AUX
admet-733	23	36	been	be	AUX
admet-733	23	37	misled	mislead	VERB
admet-733	23	38	or	or	CCONJ
admet-733	23	39	have	have	AUX
admet-733	23	40	failed	fail	VERB
admet-733	23	41	due	due	ADJ
admet-733	23	42	to	to	ADP
admet-733	23	43	spurious	spurious	ADJ
admet-733	23	44	activity	activity	NOUN
admet-733	23	45	from	from	ADP
admet-733	23	46	poorly	poorly	ADV
admet-733	23	47	characterised	characterise	VERB
admet-733	23	48	reagents	reagent	NOUN
admet-733	23	49	or	or	CCONJ
admet-733	23	50	assays	assay	NOUN
admet-733	23	51	.	.	PUNCT
admet-733	24	1	reagent	reagent	ADJ
admet-733	24	2	quality	quality	NOUN
admet-733	24	3	control	control	NOUN
admet-733	24	4	early	early	ADJ
admet-733	24	5	application	application	NOUN
admet-733	24	6	of	of	ADP
admet-733	24	7	biophysical	biophysical	ADJ
admet-733	24	8	methods	method	NOUN
admet-733	24	9	often	often	ADV
admet-733	24	10	focusses	focusse	VERB
admet-733	24	11	on	on	ADP
admet-733	24	12	understanding	understand	VERB
admet-733	24	13	the	the	DET
admet-733	24	14	quality	quality	NOUN
admet-733	24	15	of	of	ADP
admet-733	24	16	the	the	DET
admet-733	24	17	reagents	reagent	NOUN
admet-733	24	18	available	available	ADJ
admet-733	24	19	,	,	PUNCT
admet-733	24	20	both	both	CCONJ
admet-733	24	21	in	in	ADP
admet-733	24	22	terms	term	NOUN
admet-733	24	23	of	of	ADP
admet-733	24	24	the	the	DET
admet-733	24	25	suitability	suitability	NOUN
admet-733	24	26	of	of	ADP
admet-733	24	27	the	the	DET
admet-733	24	28	target	target	NOUN
admet-733	24	29	protein	protein	NOUN
admet-733	24	30	and	and	CCONJ
admet-733	24	31	of	of	ADP
admet-733	24	32	the	the	DET
admet-733	24	33	behaviour	behaviour	NOUN
admet-733	24	34	of	of	ADP
admet-733	24	35	the	the	DET
admet-733	24	36	known	know	VERB
admet-733	24	37	tool	tool	NOUN
admet-733	24	38	compounds	compound	VERB
admet-733	24	39	.	.	PUNCT
admet-733	25	1	for	for	SCONJ
admet-733	25	2	a	a	DET
admet-733	25	3	protein	protein	NOUN
admet-733	25	4	to	to	PART
admet-733	25	5	be	be	AUX
admet-733	25	6	deemed	deem	VERB
admet-733	25	7	suitable	suitable	ADJ
admet-733	25	8	to	to	PART
admet-733	25	9	be	be	AUX
admet-733	25	10	used	use	VERB
admet-733	25	11	in	in	ADP
admet-733	25	12	subsequent	subsequent	ADJ
admet-733	25	13	drug	drug	NOUN
admet-733	25	14	discovery	discovery	NOUN
admet-733	25	15	assays	assay	NOUN
admet-733	25	16	it	it	PRON
admet-733	25	17	should	should	AUX
admet-733	25	18	fit	fit	VERB
admet-733	25	19	criteria	criterion	NOUN
admet-733	25	20	associated	associate	VERB
admet-733	25	21	with	with	ADP
admet-733	25	22	the	the	DET
admet-733	25	23	group	group	NOUN
admet-733	25	24	of	of	ADP
admet-733	25	25	characteristics	characteristic	NOUN
admet-733	25	26	highlighted	highlight	VERB
admet-733	25	27	in	in	ADP
admet-733	25	28	the	the	DET
admet-733	25	29	paragraph	paragraph	NOUN
admet-733	25	30	above	above	ADV
admet-733	25	31	.	.	PUNCT
admet-733	26	1	the	the	DET
admet-733	26	2	protein	protein	NOUN
admet-733	26	3	should	should	AUX
admet-733	26	4	be	be	AUX
admet-733	26	5	the	the	DET
admet-733	26	6	right	right	ADJ
admet-733	26	7	protein	protein	NOUN
admet-733	26	8	,	,	PUNCT
admet-733	26	9	so	so	ADV
admet-733	26	10	its	its	PRON
admet-733	26	11	identity	identity	NOUN
admet-733	26	12	should	should	AUX
admet-733	26	13	be	be	AUX
admet-733	26	14	confirmed	confirm	VERB
admet-733	26	15	,	,	PUNCT
admet-733	26	16	otherwise	otherwise	ADV
admet-733	26	17	invalid	invalid	ADJ
admet-733	26	18	and	and	CCONJ
admet-733	26	19	misleading	misleading	ADJ
admet-733	26	20	results	result	NOUN
admet-733	26	21	may	may	AUX
admet-733	26	22	be	be	AUX
admet-733	26	23	obtained	obtain	VERB
admet-733	26	24	.	.	PUNCT
admet-733	27	1	the	the	DET
admet-733	27	2	purity	purity	NOUN
admet-733	27	3	of	of	ADP
admet-733	27	4	the	the	DET
admet-733	27	5	protein	protein	NOUN
admet-733	27	6	is	be	AUX
admet-733	27	7	also	also	ADV
admet-733	27	8	important	important	ADJ
admet-733	27	9	as	as	SCONJ
admet-733	27	10	impurities	impurity	NOUN
admet-733	27	11	may	may	AUX
admet-733	27	12	have	have	VERB
admet-733	27	13	similar	similar	ADJ
admet-733	27	14	activities	activity	NOUN
admet-733	27	15	or	or	CCONJ
admet-733	27	16	bind	bind	VERB
admet-733	27	17	test	test	NOUN
admet-733	27	18	compounds	compound	NOUN
admet-733	27	19	.	.	PUNCT
admet-733	28	1	the	the	DET
admet-733	28	2	concentration	concentration	NOUN
admet-733	28	3	of	of	ADP
admet-733	28	4	the	the	DET
admet-733	28	5	protein	protein	NOUN
admet-733	28	6	should	should	AUX
admet-733	28	7	be	be	AUX
admet-733	28	8	measured	measure	VERB
admet-733	28	9	so	so	SCONJ
admet-733	28	10	that	that	SCONJ
admet-733	28	11	considerations	consideration	NOUN
admet-733	28	12	around	around	ADP
admet-733	28	13	concentration	concentration	NOUN
admet-733	28	14	dependent	dependent	ADJ
admet-733	28	15	effects	effect	NOUN
admet-733	28	16	can	can	AUX
admet-733	28	17	be	be	AUX
admet-733	28	18	understood	understand	VERB
admet-733	28	19	.	.	PUNCT
admet-733	29	1	the	the	DET
admet-733	29	2	functionality	functionality	NOUN
admet-733	29	3	of	of	ADP
admet-733	29	4	the	the	DET
admet-733	29	5	protein	protein	NOUN
admet-733	29	6	should	should	AUX
admet-733	29	7	also	also	ADV
admet-733	29	8	be	be	AUX
admet-733	29	9	investigated	investigate	VERB
admet-733	29	10	.	.	PUNCT
admet-733	30	1	this	this	PRON
admet-733	30	2	may	may	AUX
admet-733	30	3	require	require	VERB
admet-733	30	4	measurements	measurement	NOUN
admet-733	30	5	of	of	ADP
admet-733	30	6	ligand	ligand	ADJ
admet-733	30	7	binding	bind	VERB
admet-733	30	8	,	,	PUNCT
admet-733	30	9	the	the	DET
admet-733	30	10	catalytic	catalytic	ADJ
admet-733	30	11	activity	activity	NOUN
admet-733	30	12	(	(	PUNCT
admet-733	30	13	in	in	ADP
admet-733	30	14	the	the	DET
admet-733	30	15	case	case	NOUN
admet-733	30	16	of	of	ADP
admet-733	30	17	enzymes	enzyme	NOUN
admet-733	30	18	)	)	PUNCT
admet-733	30	19	or	or	CCONJ
admet-733	30	20	the	the	DET
admet-733	30	21	ability	ability	NOUN
admet-733	30	22	to	to	PART
admet-733	30	23	carry	carry	VERB
admet-733	30	24	out	out	ADP
admet-733	30	25	other	other	ADJ
admet-733	30	26	functions	function	NOUN
admet-733	30	27	or	or	CCONJ
admet-733	30	28	interactions	interaction	NOUN
admet-733	30	29	.	.	PUNCT
admet-733	31	1	finally	finally	ADV
admet-733	31	2	,	,	PUNCT
admet-733	31	3	the	the	DET
admet-733	31	4	stability	stability	NOUN
admet-733	31	5	of	of	ADP
admet-733	31	6	the	the	DET
admet-733	31	7	protein	protein	NOUN
admet-733	31	8	should	should	AUX
admet-733	31	9	be	be	AUX
admet-733	31	10	assessed	assess	VERB
admet-733	31	11	,	,	PUNCT
admet-733	31	12	both	both	CCONJ
admet-733	31	13	in	in	ADP
admet-733	31	14	terms	term	NOUN
admet-733	31	15	of	of	ADP
admet-733	31	16	its	its	PRON
admet-733	31	17	thermodynamic	thermodynamic	ADJ
admet-733	31	18	and	and	CCONJ
admet-733	31	19	kinetic	kinetic	ADJ
admet-733	31	20	stability	stability	NOUN
admet-733	31	21	,	,	PUNCT
admet-733	31	22	as	as	ADV
admet-733	31	23	well	well	ADV
admet-733	31	24	as	as	ADP
admet-733	31	25	its	its	PRON
admet-733	31	26	ability	ability	NOUN
admet-733	31	27	to	to	PART
admet-733	31	28	withstand	withstand	VERB
admet-733	31	29	certain	certain	ADJ
admet-733	31	30	conditions	condition	NOUN
admet-733	31	31	such	such	ADJ
admet-733	31	32	as	as	ADP
admet-733	31	33	freeze	freeze	NOUN
admet-733	31	34	-	-	PUNCT
admet-733	31	35	thawing	thawing	NOUN
admet-733	31	36	.	.	PUNCT
admet-733	32	1	it	it	PRON
admet-733	32	2	also	also	ADV
admet-733	32	3	may	may	AUX
admet-733	32	4	be	be	AUX
admet-733	32	5	necessary	necessary	ADJ
admet-733	32	6	to	to	PART
admet-733	32	7	characterise	characterise	VERB
admet-733	32	8	the	the	DET
admet-733	32	9	binding	binding	NOUN
admet-733	32	10	of	of	ADP
admet-733	32	11	other	other	ADJ
admet-733	32	12	molecules	molecule	NOUN
admet-733	32	13	such	such	ADJ
admet-733	32	14	as	as	ADP
admet-733	32	15	substrates	substrate	NOUN
admet-733	32	16	,	,	PUNCT
admet-733	32	17	cofactors	cofactor	NOUN
admet-733	32	18	,	,	PUNCT
admet-733	32	19	binding	bind	VERB
admet-733	32	20	partners	partner	NOUN
admet-733	32	21	or	or	CCONJ
admet-733	32	22	competing	compete	VERB
admet-733	32	23	probe	probe	NOUN
admet-733	32	24	molecules	molecule	NOUN
admet-733	32	25	,	,	PUNCT
admet-733	32	26	to	to	PART
admet-733	32	27	understand	understand	VERB
admet-733	32	28	their	their	PRON
admet-733	32	29	requirement	requirement	NOUN
admet-733	32	30	and	and	CCONJ
admet-733	32	31	concentration	concentration	NOUN
admet-733	32	32	range	range	NOUN
admet-733	32	33	desired	desire	VERB
admet-733	32	34	and	and	CCONJ
admet-733	32	35	permitted	permit	VERB
admet-733	32	36	within	within	ADP
admet-733	32	37	the	the	DET
admet-733	32	38	assay	assay	NOUN
admet-733	32	39	methodologies	methodology	NOUN
admet-733	32	40	under	under	ADP
admet-733	32	41	consideration	consideration	NOUN
admet-733	32	42	.	.	PUNCT
admet-733	33	1	these	these	DET
admet-733	33	2	attributes	attribute	NOUN
admet-733	33	3	of	of	ADP
admet-733	33	4	the	the	DET
admet-733	33	5	target	target	NOUN
admet-733	33	6	protein	protein	NOUN
admet-733	33	7	may	may	AUX
admet-733	33	8	be	be	AUX
admet-733	33	9	investigated	investigate	VERB
admet-733	33	10	using	use	VERB
admet-733	33	11	a	a	DET
admet-733	33	12	variety	variety	NOUN
admet-733	33	13	of	of	ADP
admet-733	33	14	approaches	approach	NOUN
admet-733	33	15	and	and	CCONJ
admet-733	33	16	biophysical	biophysical	ADJ
admet-733	33	17	methods	method	NOUN
admet-733	33	18	can	can	AUX
admet-733	33	19	help	help	VERB
admet-733	33	20	to	to	PART
admet-733	33	21	provide	provide	VERB
admet-733	33	22	confidence	confidence	NOUN
admet-733	33	23	in	in	ADP
admet-733	33	24	the	the	DET
admet-733	33	25	target	target	NOUN
admet-733	33	26	protein	protein	NOUN
admet-733	33	27	,	,	PUNCT
admet-733	33	28	by	by	ADP
admet-733	33	29	being	be	AUX
admet-733	33	30	employed	employ	VERB
admet-733	33	31	alongside	alongside	ADV
admet-733	33	32	or	or	CCONJ
admet-733	33	33	instead	instead	ADV
admet-733	33	34	of	of	ADP
admet-733	33	35	standard	standard	ADJ
admet-733	33	36	biochemical	biochemical	ADJ
admet-733	33	37	methods	method	NOUN
admet-733	33	38	for	for	ADP
admet-733	33	39	protein	protein	NOUN
admet-733	33	40	characterisation	characterisation	NOUN
admet-733	33	41	.	.	PUNCT
admet-733	34	1	table	table	NOUN
admet-733	34	2	1	1	NUM
admet-733	34	3	shows	show	VERB
admet-733	34	4	several	several	ADJ
admet-733	34	5	possible	possible	ADJ
admet-733	34	6	methods	method	NOUN
admet-733	34	7	that	that	PRON
admet-733	34	8	may	may	AUX
admet-733	34	9	be	be	AUX
admet-733	34	10	employed	employ	VERB
admet-733	34	11	in	in	ADP
admet-733	34	12	such	such	ADJ
admet-733	34	13	characterisation	characterisation	NOUN
admet-733	34	14	and	and	CCONJ
admet-733	34	15	it	it	PRON
admet-733	34	16	highlights	highlight	VERB
admet-733	34	17	the	the	DET
admet-733	34	18	holdgate	holdgate	NOUN
admet-733	34	19	et	et	PROPN
admet-733	34	20	al	al	PROPN
admet-733	34	21	.	.	PROPN
admet-733	34	22	admet	admet	PROPN
admet-733	34	23	&	&	CCONJ
admet-733	34	24	dmpk	dmpk	PROPN
admet-733	34	25	7(4	7(4	NUM
admet-733	34	26	)	)	PUNCT
admet-733	34	27	(	(	PUNCT
admet-733	34	28	2019	2019	NUM
admet-733	34	29	)	)	PUNCT
admet-733	34	30	222	222	NUM
admet-733	34	31	-	-	SYM
admet-733	34	32	241	241	NUM
admet-733	34	33	224	224	NUM
admet-733	34	34	information	information	NOUN
admet-733	34	35	that	that	PRON
admet-733	34	36	is	be	AUX
admet-733	34	37	generated	generate	VERB
admet-733	34	38	to	to	PART
admet-733	34	39	allow	allow	VERB
admet-733	34	40	effective	effective	ADJ
admet-733	34	41	decision	decision	NOUN
admet-733	34	42	making	make	VERB
admet-733	34	43	to	to	PART
admet-733	34	44	ensure	ensure	VERB
admet-733	34	45	that	that	SCONJ
admet-733	34	46	only	only	ADJ
admet-733	34	47	protein	protein	NOUN
admet-733	34	48	of	of	ADP
admet-733	34	49	sufficient	sufficient	ADJ
admet-733	34	50	quality	quality	NOUN
admet-733	34	51	is	be	AUX
admet-733	34	52	used	use	VERB
admet-733	34	53	in	in	ADP
admet-733	34	54	hit	hit	NOUN
admet-733	34	55	-	-	PUNCT
admet-733	34	56	finding	finding	NOUN
admet-733	34	57	and	and	CCONJ
admet-733	34	58	subsequent	subsequent	ADJ
admet-733	34	59	optimisation	optimisation	NOUN
admet-733	34	60	assays	assay	NOUN
admet-733	34	61	.	.	PUNCT
admet-733	35	1	some	some	PRON
admet-733	35	2	of	of	ADP
admet-733	35	3	these	these	DET
admet-733	35	4	methods	method	NOUN
admet-733	35	5	may	may	AUX
admet-733	35	6	also	also	ADV
admet-733	35	7	be	be	AUX
admet-733	35	8	used	use	VERB
admet-733	35	9	to	to	PART
admet-733	35	10	characterise	characterise	VERB
admet-733	35	11	the	the	DET
admet-733	35	12	binding	binding	NOUN
admet-733	35	13	of	of	ADP
admet-733	35	14	ligands	ligand	NOUN
admet-733	35	15	to	to	ADP
admet-733	35	16	the	the	DET
admet-733	35	17	target	target	NOUN
admet-733	35	18	protein	protein	NOUN
admet-733	35	19	,	,	PUNCT
admet-733	35	20	to	to	PART
admet-733	35	21	evaluate	evaluate	VERB
admet-733	35	22	their	their	PRON
admet-733	35	23	purity	purity	NOUN
admet-733	35	24	and	and	CCONJ
admet-733	35	25	concentration	concentration	NOUN
admet-733	35	26	.	.	PUNCT
admet-733	36	1	table	table	NOUN
admet-733	36	2	1	1	NUM
admet-733	36	3	.	.	PUNCT
admet-733	36	4	potential	potential	ADJ
admet-733	36	5	biochemical	biochemical	ADJ
admet-733	36	6	and	and	CCONJ
admet-733	36	7	biophysical	biophysical	ADJ
admet-733	36	8	approaches	approach	NOUN
admet-733	36	9	for	for	ADP
admet-733	36	10	protein	protein	NOUN
admet-733	36	11	quality	quality	NOUN
admet-733	36	12	control	control	NOUN
admet-733	36	13	checks	check	NOUN
admet-733	36	14	.	.	PUNCT
admet-733	37	1	group	group	NOUN
admet-733	37	2	methods	method	NOUN
admet-733	37	3	(	(	PUNCT
admet-733	37	4	biochemical	biochemical	ADJ
admet-733	37	5	and	and	CCONJ
admet-733	37	6	biophysical	biophysical	ADJ
admet-733	37	7	)	)	PUNCT
admet-733	37	8	example	example	NOUN
admet-733	37	9	information	information	NOUN
admet-733	37	10	required	require	VERB
admet-733	37	11	for	for	ADP
admet-733	37	12	acceptable	acceptable	ADJ
admet-733	37	13	quality	quality	NOUN
admet-733	37	14	control	control	NOUN
admet-733	37	15	1	1	NUM
admet-733	37	16	.	.	X
admet-733	37	17	identity	identity	NOUN
admet-733	37	18	amino	amino	NOUN
admet-733	37	19	acid	acid	NOUN
admet-733	37	20	analysis	analysis	NOUN
admet-733	37	21	&	&	CCONJ
admet-733	37	22	sequencing	sequence	VERB
admet-733	37	23	exact	exact	ADJ
admet-733	37	24	,	,	PUNCT
admet-733	37	25	correct	correct	ADJ
admet-733	37	26	sequence	sequence	NOUN
admet-733	37	27	identified	identify	VERB
admet-733	37	28	lc	lc	PROPN
admet-733	37	29	-	-	PUNCT
admet-733	37	30	ms	ms	NOUN
admet-733	37	31	(	(	PUNCT
admet-733	37	32	liquid	liquid	ADJ
admet-733	37	33	chromatography	chromatography	NOUN
admet-733	37	34	-	-	PUNCT
admet-733	37	35	mass	mass	NOUN
admet-733	37	36	spectrometry	spectrometry	NOUN
admet-733	37	37	)	)	PUNCT
admet-733	37	38	correct	correct	ADJ
admet-733	37	39	relative	relative	ADJ
admet-733	37	40	molecular	molecular	ADJ
admet-733	37	41	mass	mass	NOUN
admet-733	37	42	(	(	PUNCT
admet-733	37	43	mr	mr	PROPN
admet-733	37	44	)	)	PUNCT
admet-733	37	45	within	within	ADP
admet-733	37	46	instrument	instrument	NOUN
admet-733	37	47	error	error	NOUN
admet-733	37	48	peptide	peptide	NOUN
admet-733	37	49	mapping	mapping	NOUN
admet-733	37	50	to	to	PART
admet-733	37	51	identify	identify	VERB
admet-733	37	52	post	post	VERB
admet-733	37	53	translational	translational	ADJ
admet-733	37	54	modifications	modification	NOUN
admet-733	37	55	(	(	PUNCT
admet-733	37	56	ptms	ptms	NOUN
admet-733	37	57	)	)	PUNCT
admet-733	37	58	(	(	PUNCT
admet-733	37	59	eg	eg	NOUN
admet-733	37	60	phosphorylation	phosphorylation	NOUN
admet-733	37	61	)	)	PUNCT
admet-733	37	62	number	number	NOUN
admet-733	37	63	&	&	CCONJ
admet-733	37	64	sites	site	NOUN
admet-733	37	65	of	of	ADP
admet-733	37	66	phosphorylation	phosphorylation	NOUN
admet-733	37	67	;	;	PUNCT
admet-733	37	68	extent	extent	NOUN
admet-733	37	69	of	of	ADP
admet-733	37	70	phosphorylation	phosphorylation	NOUN
admet-733	37	71	2	2	NUM
admet-733	37	72	.	.	PUNCT
admet-733	37	73	purity	purity	PROPN
admet-733	37	74	sds	sds	PROPN
admet-733	37	75	-	-	PUNCT
admet-733	37	76	page	page	NOUN
admet-733	37	77	(	(	PUNCT
admet-733	37	78	sodium	sodium	NOUN
admet-733	37	79	dodecyl	dodecyl	NOUN
admet-733	37	80	sulfate	sulfate	VERB
admet-733	37	81	–	–	PUNCT
admet-733	37	82	polyacrylamide	polyacrylamide	NOUN
admet-733	37	83	electrophoresis	electrophoresis	NOUN
admet-733	37	84	)	)	PUNCT
admet-733	37	85	/	/	SYM
admet-733	37	86	native	native	ADJ
admet-733	37	87	page	page	NOUN
admet-733	37	88	single	single	ADJ
admet-733	37	89	band	band	NOUN
admet-733	37	90	on	on	ADP
admet-733	37	91	a	a	DET
admet-733	37	92	gel	gel	NOUN
admet-733	37	93	;	;	PUNCT
admet-733	37	94	still	still	ADV
admet-733	37	95	a	a	DET
admet-733	37	96	single	single	ADJ
admet-733	37	97	band	band	NOUN
admet-733	37	98	at	at	ADP
admet-733	37	99	high	high	ADJ
admet-733	37	100	loading	loading	NOUN
admet-733	37	101	dynamic	dynamic	ADJ
admet-733	37	102	laser	laser	NOUN
admet-733	37	103	light	light	NOUN
admet-733	37	104	scattering	scattering	NOUN
admet-733	37	105	(	(	PUNCT
admet-733	37	106	dls	dls	PROPN
admet-733	37	107	)	)	PUNCT
admet-733	37	108	monodisperse	monodisperse	NOUN
admet-733	37	109	,	,	PUNCT
admet-733	37	110	mr	mr	PROPN
admet-733	37	111	±	±	PROPN
admet-733	37	112	20	20	NUM
admet-733	37	113	%	%	NOUN
admet-733	37	114	expected	expect	VERB
admet-733	37	115	analytical	analytical	ADJ
admet-733	37	116	gel	gel	NOUN
admet-733	37	117	filtration	filtration	NOUN
admet-733	37	118	defined	define	VERB
admet-733	37	119	single	single	ADJ
admet-733	37	120	gaussian	gaussian	ADJ
admet-733	37	121	peak	peak	NOUN
admet-733	37	122	for	for	ADP
admet-733	37	123	a	a	DET
admet-733	37	124	monomer	monomer	NOUN
admet-733	37	125	analytical	analytical	ADJ
admet-733	37	126	ultra	ultra	ADJ
admet-733	37	127	centrifugation	centrifugation	NOUN
admet-733	37	128	(	(	PUNCT
admet-733	37	129	auc	auc	NOUN
admet-733	37	130	)	)	PUNCT
admet-733	37	131	indicates	indicate	VERB
admet-733	37	132	homogeneity	homogeneity	NOUN
admet-733	37	133	&	&	CCONJ
admet-733	37	134	correct	correct	VERB
admet-733	37	135	mr	mr	PROPN
admet-733	37	136	3	3	NUM
admet-733	37	137	.	.	PUNCT
admet-733	37	138	concentration	concentration	NOUN
admet-733	37	139	ultraviolet	ultraviolet	NOUN
admet-733	37	140	(	(	PUNCT
admet-733	37	141	uv	uv	NOUN
admet-733	37	142	)	)	PUNCT
admet-733	37	143	spectrum	spectrum	NOUN
admet-733	37	144	peak	peak	NOUN
admet-733	37	145	at	at	ADP
admet-733	37	146	280	280	NUM
admet-733	37	147	nm	nm	NOUN
admet-733	37	148	;	;	PUNCT
admet-733	37	149	peak	peak	NOUN
admet-733	37	150	at	at	ADP
admet-733	37	151	205	205	NUM
admet-733	37	152	nm	nm	NOUN
admet-733	37	153	;	;	PUNCT
admet-733	37	154	no	no	DET
admet-733	37	155	peaks	peak	NOUN
admet-733	37	156	above	above	ADP
admet-733	37	157	~	~	PUNCT
admet-733	37	158	340	340	NUM
admet-733	37	159	nm	nm	NOUN
admet-733	37	160	;	;	PUNCT
admet-733	37	161	test	test	NOUN
admet-733	37	162	for	for	ADP
admet-733	37	163	light	light	ADJ
admet-733	37	164	scattering	scattering	NOUN
admet-733	37	165	(	(	PUNCT
admet-733	37	166	look	look	VERB
admet-733	37	167	into	into	ADP
admet-733	37	168	ratio	ratio	NOUN
admet-733	37	169	at	at	ADP
admet-733	37	170	different	different	ADJ
admet-733	37	171	wavelengths	wavelength	NOUN
admet-733	37	172	eg	eg	ADP
admet-733	37	173	a280	a280	PROPN
admet-733	37	174	/	/	SYM
admet-733	37	175	a230	a230	PROPN
admet-733	37	176	)	)	PUNCT
admet-733	37	177	;	;	PUNCT
admet-733	37	178	concentration	concentration	NOUN
admet-733	37	179	calculated	calculate	VERB
admet-733	37	180	using	use	VERB
admet-733	37	181	ε	ε	PROPN
admet-733	37	182	bradford	bradford	PROPN
admet-733	37	183	assay	assay	VERB
admet-733	37	184	linearity	linearity	PROPN
admet-733	37	185	with	with	ADP
admet-733	37	186	bsa	bsa	PROPN
admet-733	37	187	standards	standard	NOUN
admet-733	37	188	4	4	NUM
admet-733	37	189	.	.	PUNCT
admet-733	37	190	functionality	functionality	NOUN
admet-733	37	191	functional	functional	ADJ
admet-733	37	192	assay	assay	ADJ
admet-733	37	193	functional	functional	ADJ
admet-733	37	194	activity	activity	NOUN
admet-733	37	195	observed	observe	VERB
admet-733	37	196	with	with	ADP
admet-733	37	197	expected	expect	VERB
admet-733	37	198	parameters	parameter	NOUN
admet-733	37	199	(	(	PUNCT
admet-733	37	200	eg	eg	PROPN
admet-733	37	201	kcat	kcat	PROPN
admet-733	37	202	,	,	PUNCT
admet-733	37	203	km	km	PROPN
admet-733	37	204	,	,	PUNCT
admet-733	37	205	kcat	kcat	ADJ
admet-733	37	206	/	/	SYM
admet-733	37	207	km	km	NOUN
admet-733	37	208	)	)	PUNCT
admet-733	37	209	isothermal	isothermal	ADJ
admet-733	37	210	calorimetry	calorimetry	NOUN
admet-733	37	211	(	(	PUNCT
admet-733	37	212	itc	itc	PROPN
admet-733	37	213	)	)	PUNCT
admet-733	37	214	with	with	ADP
admet-733	37	215	known	know	VERB
admet-733	37	216	tool	tool	NOUN
admet-733	37	217	ligand	ligand	NOUN
admet-733	37	218	:	:	PUNCT
admet-733	38	1	n	n	PROPN
admet-733	38	2			PROPN
admet-733	38	3	15	15	NUM
admet-733	38	4	%	%	NOUN
admet-733	38	5	of	of	ADP
admet-733	38	6	expected	expect	VERB
admet-733	38	7	;	;	PUNCT
admet-733	38	8	kd	kd	PROPN
admet-733	38	9	within	within	ADP
admet-733	38	10	2	2	NUM
admet-733	38	11	-	-	ADJ
admet-733	38	12	fold	fold	NOUN
admet-733	38	13	of	of	ADP
admet-733	38	14	reference	reference	NOUN
admet-733	38	15	value	value	NOUN
admet-733	38	16	;	;	PUNCT
admet-733	38	17	h	h	NOUN
admet-733	38	18	within	within	ADP
admet-733	38	19	1	1	NUM
admet-733	38	20	kcal	kcal	NOUN
admet-733	38	21	/	/	SYM
admet-733	38	22	mol	mol	ADP
admet-733	38	23	surface	surface	NOUN
admet-733	38	24	plasmon	plasmon	NOUN
admet-733	38	25	resonance	resonance	NOUN
admet-733	38	26	(	(	PUNCT
admet-733	38	27	spr	spr	ADJ
admet-733	38	28	)	)	PUNCT
admet-733	38	29	direct	direct	ADJ
admet-733	38	30	binding	bind	VERB
admet-733	38	31	assay	assay	NOUN
admet-733	38	32	(	(	PUNCT
admet-733	38	33	dba	dba	PROPN
admet-733	38	34	):	):	PUNCT
admet-733	38	35	kd	kd	PROPN
admet-733	38	36	within	within	ADP
admet-733	38	37	2	2	NUM
admet-733	38	38	-	-	ADJ
admet-733	38	39	fold	fold	NOUN
admet-733	38	40	of	of	ADP
admet-733	38	41	reference	reference	NOUN
admet-733	38	42	value	value	NOUN
admet-733	38	43	;	;	PUNCT
admet-733	38	44	expected	expect	VERB
admet-733	38	45	theoretical	theoretical	ADJ
admet-733	38	46	rmax	rmax	NOUN
admet-733	38	47	;	;	PUNCT
admet-733	38	48	inhibition	inhibition	NOUN
admet-733	38	49	in	in	ADP
admet-733	38	50	solution	solution	NOUN
admet-733	38	51	assay	assay	PROPN
admet-733	38	52	(	(	PUNCT
admet-733	38	53	isa	isa	NOUN
admet-733	38	54	):	):	PUNCT
admet-733	38	55	[	[	X
admet-733	38	56	protein	protein	NOUN
admet-733	38	57	]	]	PUNCT
admet-733	38	58	within	within	ADP
admet-733	38	59	±15	±15	NOUN
admet-733	38	60	%	%	NOUN
admet-733	38	61	of	of	ADP
admet-733	38	62	two	two	NUM
admet-733	38	63	different	different	ADJ
admet-733	38	64	concentration	concentration	NOUN
admet-733	38	65	measures	measure	NOUN
admet-733	38	66	(	(	PUNCT
admet-733	38	67	bradford	bradford	NOUN
admet-733	38	68	&	&	CCONJ
admet-733	38	69	a280	a280	PROPN
admet-733	38	70	)	)	PUNCT
admet-733	38	71	;	;	PUNCT
admet-733	38	72	competition	competition	NOUN
admet-733	38	73	observed	observe	VERB
admet-733	38	74	between	between	ADP
admet-733	38	75	target	target	NOUN
admet-733	38	76	definition	definition	NOUN
admet-733	38	77	compound	compound	NOUN
admet-733	38	78	(	(	PUNCT
admet-733	38	79	tdc	tdc	PROPN
admet-733	38	80	)	)	PUNCT
admet-733	38	81	and	and	CCONJ
admet-733	38	82	tdc	tdc	PROPN
admet-733	38	83	in	in	ADP
admet-733	38	84	solution	solution	NOUN
admet-733	38	85	functional	functional	ADJ
admet-733	38	86	comparison	comparison	NOUN
admet-733	38	87	between	between	ADP
admet-733	38	88	protein	protein	NOUN
admet-733	38	89	batches	batch	NOUN
admet-733	38	90	compare	compare	VERB
admet-733	38	91	kd	kd	PROPN
admet-733	38	92	,	,	PUNCT
admet-733	38	93	h	h	PROPN
admet-733	38	94	,	,	PUNCT
admet-733	38	95	stoichiometry	stoichiometry	NOUN
admet-733	38	96	,	,	PUNCT
admet-733	38	97	km	km	PROPN
admet-733	38	98	,	,	PUNCT
admet-733	38	99	kcat	kcat	PROPN
admet-733	38	100	,	,	PUNCT
admet-733	38	101	kcat	kcat	ADJ
admet-733	38	102	/	/	SYM
admet-733	38	103	km	km	NOUN
admet-733	38	104	(	(	PUNCT
admet-733	38	105	usually	usually	ADV
admet-733	38	106	>	>	X
admet-733	38	107	10	10	NUM
admet-733	38	108	6	6	NUM
admet-733	38	109	s	s	NOUN
admet-733	38	110	-1	-1	NOUN
admet-733	38	111	m	m	NOUN
admet-733	38	112	-1	-1	ADJ
admet-733	38	113	)	)	PUNCT
admet-733	38	114	,	,	PUNCT
admet-733	38	115	ki	ki	PROPN
admet-733	38	116	;	;	PUNCT
admet-733	38	117	single	single	ADJ
admet-733	38	118	phase	phase	NOUN
admet-733	38	119	kinetics	kinetic	VERB
admet-733	38	120	validity	validity	NOUN
admet-733	38	121	of	of	ADP
admet-733	38	122	construct	construct	NOUN
admet-733	38	123	compare	compare	NOUN
admet-733	38	124	kd	kd	PROPN
admet-733	38	125	,	,	PUNCT
admet-733	38	126	km	km	PROPN
admet-733	38	127	,	,	PUNCT
admet-733	38	128	ki	ki	PROPN
admet-733	38	129	,	,	PUNCT
admet-733	38	130	h	h	VERB
admet-733	38	131	with	with	ADP
admet-733	38	132	full	full	ADJ
admet-733	38	133	-	-	PUNCT
admet-733	38	134	length	length	NOUN
admet-733	38	135	protein	protein	NOUN
admet-733	38	136	;	;	PUNCT
admet-733	38	137	compare	compare	VERB
admet-733	38	138	structure	structure	NOUN
admet-733	38	139	-	-	PUNCT
admet-733	38	140	activity	activity	NOUN
admet-733	38	141	relationship	relationship	NOUN
admet-733	38	142	(	(	PUNCT
admet-733	38	143	sar	sar	PROPN
admet-733	38	144	)	)	PUNCT
admet-733	38	145	5	5	NUM
admet-733	38	146	.	.	PUNCT
admet-733	38	147	stability	stability	NOUN
admet-733	38	148	differential	differential	NOUN
admet-733	38	149	scanning	scan	VERB
admet-733	38	150	calorimetry	calorimetry	NOUN
admet-733	38	151	(	(	PUNCT
admet-733	38	152	dsc	dsc	NOUN
admet-733	38	153	)	)	PUNCT
admet-733	38	154	good	good	ADJ
admet-733	38	155	pre	pre	ADJ
admet-733	38	156	-	-	ADJ
admet-733	38	157	transition	transition	ADJ
admet-733	38	158	baseline	baseline	NOUN
admet-733	38	159	;	;	PUNCT
admet-733	38	160	visible	visible	ADJ
admet-733	38	161	tm	tm	NOUN
admet-733	38	162	(	(	PUNCT
admet-733	38	163	above	above	ADP
admet-733	38	164	37	37	NUM
admet-733	38	165	°	°	NOUN
admet-733	38	166	c	c	NOUN
admet-733	38	167	)	)	PUNCT
admet-733	38	168	;	;	PUNCT
admet-733	38	169	good	good	ADJ
admet-733	38	170	post	post	ADJ
admet-733	38	171	-	-	ADJ
admet-733	38	172	transition	transition	ADJ
admet-733	38	173	baseline	baseline	NOUN
admet-733	38	174	differential	differential	NOUN
admet-733	38	175	scanning	scan	VERB
admet-733	38	176	fluorimetry	fluorimetry	NOUN
admet-733	38	177	(	(	PUNCT
admet-733	38	178	dsf	dsf	PROPN
admet-733	38	179	)	)	PUNCT
admet-733	38	180	good	good	ADJ
admet-733	38	181	pre	pre	ADJ
admet-733	38	182	-	-	ADJ
admet-733	38	183	transition	transition	ADJ
admet-733	38	184	baseline	baseline	NOUN
admet-733	38	185	;	;	PUNCT
admet-733	38	186	visible	visible	ADJ
admet-733	38	187	tm	tm	NOUN
admet-733	38	188	(	(	PUNCT
admet-733	38	189	above	above	ADP
admet-733	38	190	37	37	NUM
admet-733	38	191	°	°	NOUN
admet-733	38	192	c	c	NOUN
admet-733	38	193	)	)	PUNCT
admet-733	38	194	;	;	PUNCT
admet-733	38	195	good	good	ADJ
admet-733	38	196	post	post	ADJ
admet-733	38	197	-	-	ADJ
admet-733	38	198	transition	transition	ADJ
admet-733	38	199	baseline	baseline	PROPN
admet-733	38	200	selwyn	selwyn	PROPN
admet-733	38	201	’s	’s	PART
admet-733	38	202	test	test	NOUN
admet-733	38	203	overlay	overlay	NOUN
admet-733	38	204	of	of	ADP
admet-733	38	205	plots	plot	NOUN
admet-733	38	206	of	of	ADP
admet-733	38	207	[	[	X
admet-733	38	208	p	p	X
admet-733	38	209	]	]	X
admet-733	38	210	vs	vs	ADP
admet-733	38	211	[	[	X
admet-733	38	212	e].t	e].t	X
admet-733	38	213	for	for	ADP
admet-733	38	214	different	different	ADJ
admet-733	38	215	combinations	combination	NOUN
admet-733	38	216	of	of	ADP
admet-733	38	217	[	[	X
admet-733	38	218	e	e	X
admet-733	38	219	]	]	PUNCT
admet-733	38	220	and	and	CCONJ
admet-733	38	221	t	t	PROPN
admet-733	38	222	where	where	SCONJ
admet-733	38	223	lc	lc	NOUN
admet-733	38	224	-	-	PUNCT
admet-733	38	225	ms	ms	PROPN
admet-733	38	226	is	be	AUX
admet-733	38	227	liquid	liquid	ADJ
admet-733	38	228	chromatography	chromatography	NOUN
admet-733	38	229	mass	mass	NOUN
admet-733	38	230	spectrometry	spectrometry	NOUN
admet-733	38	231	,	,	PUNCT
admet-733	38	232	ptm	ptm	PROPN
admet-733	38	233	is	be	AUX
admet-733	38	234	post	post	ADJ
admet-733	38	235	translational	translational	ADJ
admet-733	38	236	modification	modification	NOUN
admet-733	38	237	,	,	PUNCT
admet-733	38	238	uv	uv	PROPN
admet-733	38	239	is	be	AUX
admet-733	38	240	ultraviolet	ultraviolet	ADJ
admet-733	38	241	,	,	PUNCT
admet-733	38	242	mr	mr	PROPN
admet-733	38	243	is	be	AUX
admet-733	38	244	relative	relative	ADJ
admet-733	38	245	molecular	molecular	ADJ
admet-733	38	246	mass	mass	NOUN
admet-733	38	247	,	,	PUNCT
admet-733	38	248	bsa	bsa	PROPN
admet-733	38	249	is	be	AUX
admet-733	38	250	bovine	bovine	ADJ
admet-733	38	251	serum	serum	NOUN
admet-733	38	252	albumin	albumin	NOUN
admet-733	38	253	,	,	PUNCT
admet-733	38	254	ε	ε	PROPN
admet-733	38	255	is	be	AUX
admet-733	38	256	the	the	DET
admet-733	38	257	molar	molar	ADJ
admet-733	38	258	extinction	extinction	NOUN
admet-733	38	259	coefficient	coefficient	NOUN
admet-733	38	260	,	,	PUNCT
admet-733	38	261	kcat	kcat	PROPN
admet-733	38	262	is	be	AUX
admet-733	38	263	turnover	turnover	NOUN
admet-733	38	264	number	number	NOUN
admet-733	38	265	,	,	PUNCT
admet-733	38	266	km	km	PROPN
admet-733	38	267	is	be	AUX
admet-733	38	268	michaelis	michaeli	NOUN
admet-733	38	269	constant	constant	ADJ
admet-733	38	270	,	,	PUNCT
admet-733	38	271	n	n	PRON
admet-733	38	272	is	be	AUX
admet-733	38	273	stoichiometry	stoichiometry	NOUN
admet-733	38	274	,	,	PUNCT
admet-733	38	275	kd	kd	PROPN
admet-733	38	276	is	be	AUX
admet-733	38	277	equilibrium	equilibrium	NOUN
admet-733	38	278	dissociation	dissociation	NOUN
admet-733	38	279	constant	constant	ADJ
admet-733	38	280	,	,	PUNCT
admet-733	38	281	h	h	NOUN
admet-733	38	282	is	be	AUX
admet-733	38	283	binding	bind	VERB
admet-733	38	284	enthalpy	enthalpy	NOUN
admet-733	38	285	,	,	PUNCT
admet-733	38	286	dba	dba	PROPN
admet-733	38	287	is	be	AUX
admet-733	38	288	direct	direct	ADJ
admet-733	38	289	binding	bind	VERB
admet-733	38	290	assay	assay	NOUN
admet-733	38	291	,	,	PUNCT
admet-733	38	292	isa	isa	NOUN
admet-733	38	293	is	be	AUX
admet-733	38	294	inhibition	inhibition	NOUN
admet-733	38	295	in	in	ADP
admet-733	38	296	solution	solution	NOUN
admet-733	38	297	assay	assay	VERB
admet-733	38	298	,	,	PUNCT
admet-733	38	299	rmax	rmax	PROPN
admet-733	38	300	is	be	AUX
admet-733	38	301	maximum	maximum	ADJ
admet-733	38	302	response	response	NOUN
admet-733	38	303	,	,	PUNCT
admet-733	38	304	tdc	tdc	PROPN
admet-733	38	305	is	be	AUX
admet-733	38	306	target	target	NOUN
admet-733	38	307	definition	definition	NOUN
admet-733	38	308	compound	compound	NOUN
admet-733	38	309	,	,	PUNCT
admet-733	38	310	sar	sar	PROPN
admet-733	38	311	is	be	AUX
admet-733	38	312	structure	structure	NOUN
admet-733	38	313	activity	activity	NOUN
admet-733	38	314	relationship	relationship	NOUN
admet-733	38	315	,	,	PUNCT
admet-733	38	316	tm	tm	PROPN
admet-733	38	317	is	be	AUX
admet-733	38	318	the	the	DET
admet-733	38	319	the	the	DET
admet-733	38	320	melting	melting	NOUN
admet-733	38	321	temperature	temperature	NOUN
admet-733	38	322	,	,	PUNCT
admet-733	39	1	[	[	X
admet-733	39	2	p	p	X
admet-733	39	3	]	]	X
admet-733	39	4	is	be	AUX
admet-733	39	5	product	product	NOUN
admet-733	39	6	concentration	concentration	NOUN
admet-733	39	7	,	,	PUNCT
admet-733	39	8	[	[	X
admet-733	39	9	e	e	X
admet-733	39	10	]	]	X
admet-733	39	11	is	be	AUX
admet-733	39	12	enzyme	enzyme	NOUN
admet-733	39	13	concentration	concentration	NOUN
admet-733	39	14	,	,	PUNCT
admet-733	39	15	t	t	PROPN
admet-733	39	16	is	be	AUX
admet-733	39	17	time	time	NOUN
admet-733	39	18	.	.	PUNCT
admet-733	40	1	clearly	clearly	ADV
admet-733	40	2	,	,	PUNCT
admet-733	40	3	it	it	PRON
admet-733	40	4	is	be	AUX
admet-733	40	5	essential	essential	ADJ
admet-733	40	6	to	to	PART
admet-733	40	7	understand	understand	VERB
admet-733	40	8	the	the	DET
admet-733	40	9	quality	quality	NOUN
admet-733	40	10	of	of	ADP
admet-733	40	11	the	the	DET
admet-733	40	12	protein	protein	NOUN
admet-733	40	13	and	and	CCONJ
admet-733	40	14	its	its	PRON
admet-733	40	15	behaviour	behaviour	NOUN
admet-733	40	16	before	before	ADP
admet-733	40	17	significant	significant	ADJ
admet-733	40	18	time	time	NOUN
admet-733	40	19	is	be	AUX
admet-733	40	20	admet	admet	PROPN
admet-733	40	21	&	&	CCONJ
admet-733	40	22	dmpk	dmpk	PROPN
admet-733	40	23	7(4	7(4	NUM
admet-733	40	24	)	)	PUNCT
admet-733	40	25	(	(	PUNCT
admet-733	40	26	2019	2019	NUM
admet-733	40	27	)	)	PUNCT
admet-733	40	28	222	222	NUM
admet-733	40	29	-	-	PUNCT
admet-733	40	30	241	241	NUM
admet-733	40	31	biophysical	biophysical	ADJ
admet-733	40	32	methods	method	NOUN
admet-733	40	33	in	in	ADP
admet-733	40	34	early	early	ADJ
admet-733	40	35	drug	drug	NOUN
admet-733	40	36	discovery	discovery	NOUN
admet-733	40	37	doi	doi	PROPN
admet-733	40	38	:	:	PUNCT
admet-733	40	39	10.5599	10.5599	NUM
admet-733	40	40	/	/	SYM
admet-733	40	41	admet.733	admet.733	ADJ
admet-733	40	42	225	225	NUM
admet-733	40	43	spent	spend	VERB
admet-733	40	44	developing	develop	VERB
admet-733	40	45	assays	assay	NOUN
admet-733	40	46	and	and	CCONJ
admet-733	40	47	certainly	certainly	ADV
admet-733	40	48	before	before	SCONJ
admet-733	40	49	bulk	bulk	ADJ
admet-733	40	50	amounts	amount	NOUN
admet-733	40	51	of	of	ADP
admet-733	40	52	protein	protein	NOUN
admet-733	40	53	are	be	AUX
admet-733	40	54	made	make	VERB
admet-733	40	55	for	for	ADP
admet-733	40	56	activities	activity	NOUN
admet-733	40	57	such	such	ADJ
admet-733	40	58	as	as	ADP
admet-733	40	59	highthroughput	highthroughput	NOUN
admet-733	40	60	screening	screening	NOUN
admet-733	40	61	and	and	CCONJ
admet-733	40	62	x	x	NOUN
admet-733	40	63	-	-	NOUN
admet-733	40	64	ray	ray	NOUN
admet-733	40	65	crystallography	crystallography	NOUN
admet-733	40	66	.	.	PUNCT
admet-733	41	1	in	in	ADP
admet-733	41	2	this	this	DET
admet-733	41	3	respect	respect	NOUN
admet-733	41	4	it	it	PRON
admet-733	41	5	is	be	AUX
admet-733	41	6	useful	useful	ADJ
admet-733	41	7	to	to	PART
admet-733	41	8	remember	remember	VERB
admet-733	41	9	that	that	SCONJ
admet-733	41	10	the	the	DET
admet-733	41	11	target	target	NOUN
admet-733	41	12	protein	protein	NOUN
admet-733	41	13	goes	go	VERB
admet-733	41	14	into	into	ADP
admet-733	41	15	every	every	DET
admet-733	41	16	well	well	NOUN
admet-733	41	17	of	of	ADP
admet-733	41	18	the	the	DET
admet-733	41	19	experiment	experiment	NOUN
admet-733	41	20	,	,	PUNCT
admet-733	41	21	and	and	CCONJ
admet-733	41	22	so	so	ADV
admet-733	41	23	issues	issue	NOUN
admet-733	41	24	with	with	ADP
admet-733	41	25	the	the	DET
admet-733	41	26	performance	performance	NOUN
admet-733	41	27	of	of	ADP
admet-733	41	28	this	this	DET
admet-733	41	29	reagent	reagent	NOUN
admet-733	41	30	has	have	VERB
admet-733	41	31	the	the	DET
admet-733	41	32	potential	potential	NOUN
admet-733	41	33	to	to	PART
admet-733	41	34	compromise	compromise	VERB
admet-733	41	35	the	the	DET
admet-733	41	36	entire	entire	ADJ
admet-733	41	37	experiment	experiment	NOUN
admet-733	41	38	.	.	PUNCT
admet-733	42	1	this	this	PRON
admet-733	42	2	can	can	AUX
admet-733	42	3	be	be	AUX
admet-733	42	4	contrasted	contrast	VERB
admet-733	42	5	with	with	ADP
admet-733	42	6	efforts	effort	NOUN
admet-733	42	7	to	to	PART
admet-733	42	8	ensure	ensure	VERB
admet-733	42	9	individual	individual	ADJ
admet-733	42	10	compound	compound	NOUN
admet-733	42	11	purity	purity	NOUN
admet-733	42	12	and	and	CCONJ
admet-733	42	13	activity	activity	NOUN
admet-733	42	14	.	.	PUNCT
admet-733	43	1	although	although	SCONJ
admet-733	43	2	individual	individual	ADJ
admet-733	43	3	compound	compound	NOUN
admet-733	43	4	integrity	integrity	NOUN
admet-733	43	5	is	be	AUX
admet-733	43	6	important	important	ADJ
admet-733	43	7	to	to	PART
admet-733	43	8	ensure	ensure	VERB
admet-733	43	9	that	that	SCONJ
admet-733	43	10	the	the	DET
admet-733	43	11	identification	identification	NOUN
admet-733	43	12	of	of	ADP
admet-733	43	13	useful	useful	ADJ
admet-733	43	14	chemical	chemical	NOUN
admet-733	43	15	start	start	NOUN
admet-733	43	16	points	point	NOUN
admet-733	43	17	from	from	ADP
admet-733	43	18	any	any	DET
admet-733	43	19	active	active	ADJ
admet-733	43	20	hit	hit	NOUN
admet-733	43	21	compound	compound	NOUN
admet-733	43	22	is	be	AUX
admet-733	43	23	not	not	PART
admet-733	43	24	missed	miss	VERB
admet-733	43	25	,	,	PUNCT
admet-733	43	26	it	it	PRON
admet-733	43	27	does	do	AUX
admet-733	43	28	not	not	PART
admet-733	43	29	have	have	VERB
admet-733	43	30	the	the	DET
admet-733	43	31	same	same	ADJ
admet-733	43	32	propensity	propensity	NOUN
admet-733	43	33	to	to	PART
admet-733	43	34	compromise	compromise	VERB
admet-733	43	35	the	the	DET
admet-733	43	36	whole	whole	ADJ
admet-733	43	37	hit	hit	VERB
admet-733	43	38	identification	identification	NOUN
admet-733	43	39	process	process	NOUN
admet-733	43	40	,	,	PUNCT
admet-733	43	41	as	as	SCONJ
admet-733	43	42	would	would	AUX
admet-733	43	43	be	be	AUX
admet-733	43	44	the	the	DET
admet-733	43	45	case	case	NOUN
admet-733	43	46	for	for	ADP
admet-733	43	47	a	a	DET
admet-733	43	48	protein	protein	NOUN
admet-733	43	49	of	of	ADP
admet-733	43	50	questionable	questionable	ADJ
admet-733	43	51	integrity	integrity	NOUN
admet-733	43	52	.	.	PUNCT
admet-733	44	1	protein	protein	NOUN
admet-733	44	2	integrity	integrity	NOUN
admet-733	44	3	,	,	PUNCT
admet-733	44	4	and	and	CCONJ
admet-733	44	5	its	its	PRON
admet-733	44	6	resulting	result	VERB
admet-733	44	7	ability	ability	NOUN
admet-733	44	8	to	to	PART
admet-733	44	9	bind	bind	VERB
admet-733	44	10	to	to	ADP
admet-733	44	11	test	test	NOUN
admet-733	44	12	compounds	compound	NOUN
admet-733	44	13	which	which	PRON
admet-733	44	14	may	may	AUX
admet-733	44	15	then	then	ADV
admet-733	44	16	modulate	modulate	VERB
admet-733	44	17	the	the	DET
admet-733	44	18	biological	biological	ADJ
admet-733	44	19	function	function	NOUN
admet-733	44	20	,	,	PUNCT
admet-733	44	21	can	can	AUX
admet-733	44	22	be	be	AUX
admet-733	44	23	compromised	compromise	VERB
admet-733	44	24	in	in	ADP
admet-733	44	25	several	several	ADJ
admet-733	44	26	ways	way	NOUN
admet-733	44	27	,	,	PUNCT
admet-733	44	28	some	some	DET
admet-733	44	29	examples	example	NOUN
admet-733	44	30	of	of	ADP
admet-733	44	31	which	which	PRON
admet-733	44	32	are	be	AUX
admet-733	44	33	illustrated	illustrate	VERB
admet-733	44	34	in	in	ADP
admet-733	44	35	table	table	NOUN
admet-733	44	36	2	2	NUM
admet-733	44	37	.	.	PUNCT
admet-733	44	38	table	table	NOUN
admet-733	44	39	2	2	NUM
admet-733	44	40	.	.	PUNCT
admet-733	45	1	examples	example	NOUN
admet-733	45	2	of	of	ADP
admet-733	45	3	factors	factor	NOUN
admet-733	45	4	that	that	PRON
admet-733	45	5	have	have	AUX
admet-733	45	6	compromised	compromise	VERB
admet-733	45	7	protein	protein	NOUN
admet-733	45	8	integrity	integrity	NOUN
admet-733	45	9	for	for	ADP
admet-733	45	10	use	use	NOUN
admet-733	45	11	in	in	ADP
admet-733	45	12	drug	drug	NOUN
admet-733	45	13	discovery	discovery	NOUN
admet-733	45	14	projects	project	NOUN
admet-733	45	15	,	,	PUNCT
admet-733	45	16	resulting	result	VERB
admet-733	45	17	observations	observation	NOUN
admet-733	45	18	and	and	CCONJ
admet-733	45	19	actions	action	NOUN
admet-733	45	20	taken	take	VERB
admet-733	45	21	to	to	PART
admet-733	45	22	overcome	overcome	VERB
admet-733	45	23	the	the	DET
admet-733	45	24	issues	issue	NOUN
admet-733	45	25	.	.	PUNCT
admet-733	46	1	protein	protein	NOUN
admet-733	46	2	target	target	NOUN
admet-733	46	3	quality	quality	NOUN
admet-733	46	4	control	control	NOUN
admet-733	46	5	issue	issue	NOUN
admet-733	46	6	biophysical	biophysical	ADJ
admet-733	46	7	methods	method	NOUN
admet-733	46	8	employed	employ	VERB
admet-733	46	9	observations	observation	NOUN
admet-733	46	10	actions	action	NOUN
admet-733	46	11	taken	take	VERB
admet-733	46	12	lactate	lactate	NOUN
admet-733	46	13	dehydrogenase	dehydrogenase	NOUN
admet-733	46	14	cofactor	cofactor	NOUN
admet-733	46	15	present	present	NOUN
admet-733	46	16	in	in	ADP
admet-733	46	17	protein	protein	NOUN
admet-733	46	18	preparation	preparation	NOUN
admet-733	46	19	itc	itc	PROPN
admet-733	46	20	,	,	PUNCT
admet-733	46	21	spr	spr	ADJ
admet-733	46	22	tool	tool	NOUN
admet-733	46	23	compounds	compound	NOUN
admet-733	46	24	and	and	CCONJ
admet-733	46	25	added	add	VERB
admet-733	46	26	cofactor	cofactor	NOUN
admet-733	46	27	binding	bind	VERB
admet-733	46	28	more	more	ADV
admet-733	46	29	weakly	weakly	ADJ
admet-733	46	30	than	than	SCONJ
admet-733	46	31	expected	expect	VERB
admet-733	46	32	new	new	ADJ
admet-733	46	33	purification	purification	NOUN
admet-733	46	34	method	method	NOUN
admet-733	46	35	established	establish	VERB
admet-733	46	36	atad2	atad2	ADJ
admet-733	46	37	protein	protein	NOUN
admet-733	46	38	aggregation	aggregation	NOUN
admet-733	46	39	nmr	nmr	NOUN
admet-733	46	40	,	,	PUNCT
admet-733	46	41	itc	itc	PROPN
admet-733	46	42	,	,	PUNCT
admet-733	46	43	tsa	tsa	NOUN
admet-733	46	44	protein	protein	NOUN
admet-733	46	45	showing	show	VERB
admet-733	46	46	poor	poor	ADJ
admet-733	46	47	spectrum	spectrum	NOUN
admet-733	46	48	,	,	PUNCT
admet-733	46	49	negative	negative	ADJ
admet-733	46	50	shifts	shift	NOUN
admet-733	46	51	with	with	ADP
admet-733	46	52	compounds	compound	NOUN
admet-733	46	53	in	in	ADP
admet-733	46	54	tsa	tsa	NOUN
admet-733	46	55	,	,	PUNCT
admet-733	46	56	no	no	DET
admet-733	46	57	binding	binding	NOUN
admet-733	46	58	of	of	ADP
admet-733	46	59	tool	tool	NOUN
admet-733	46	60	compounds	compound	VERB
admet-733	46	61	new	new	ADJ
admet-733	46	62	construct	construct	NOUN
admet-733	46	63	designed	design	VERB
admet-733	46	64	acper	acper	NOUN
admet-733	46	65	reduced	reduce	VERB
admet-733	46	66	binding	bind	VERB
admet-733	46	67	functionality	functionality	NOUN
admet-733	46	68	itc	itc	PROPN
admet-733	46	69	low	low	ADJ
admet-733	46	70	stoichiometry	stoichiometry	NOUN
admet-733	46	71	and	and	CCONJ
admet-733	46	72	enthalpy	enthalpy	NOUN
admet-733	46	73	for	for	ADP
admet-733	46	74	cofactor	cofactor	NOUN
admet-733	46	75	binding	bind	VERB
admet-733	46	76	new	new	ADJ
admet-733	46	77	batch	batch	NOUN
admet-733	46	78	of	of	ADP
admet-733	46	79	protein	protein	NOUN
admet-733	46	80	prepared	prepare	VERB
admet-733	46	81	mapkapk2	mapkapk2	NOUN
admet-733	47	1	no	no	DET
admet-733	47	2	binding	bind	VERB
admet-733	47	3	to	to	ADP
admet-733	47	4	p38	p38	NOUN
admet-733	47	5	nmr	nmr	NOUN
admet-733	47	6	,	,	PUNCT
admet-733	47	7	itc	itc	PROPN
admet-733	47	8	short	short	ADJ
admet-733	47	9	construct	construct	NOUN
admet-733	47	10	used	use	VERB
admet-733	47	11	for	for	ADP
admet-733	47	12	nmr	nmr	NOUN
admet-733	47	13	did	do	AUX
admet-733	47	14	not	not	PART
admet-733	47	15	show	show	VERB
admet-733	47	16	binding	bind	VERB
admet-733	47	17	to	to	ADP
admet-733	47	18	p38	p38	VERB
admet-733	47	19	and	and	CCONJ
admet-733	47	20	differences	difference	NOUN
admet-733	47	21	in	in	ADP
admet-733	47	22	compound	compound	NOUN
admet-733	47	23	affinity	affinity	NOUN
admet-733	47	24	observed	observe	VERB
admet-733	47	25	for	for	ADP
admet-733	47	26	long	long	ADJ
admet-733	47	27	and	and	CCONJ
admet-733	47	28	short	short	ADJ
admet-733	47	29	constructs	construct	NOUN
admet-733	47	30	in	in	ADP
admet-733	47	31	phosphorylation	phosphorylation	NOUN
admet-733	47	32	assays	assay	NOUN
admet-733	47	33	longer	long	ADV
admet-733	47	34	construct	construct	VERB
admet-733	47	35	,	,	PUNCT
admet-733	47	36	containing	contain	VERB
admet-733	47	37	putative	putative	ADJ
admet-733	47	38	site	site	NOUN
admet-733	47	39	for	for	ADP
admet-733	47	40	p38a	p38a	NOUN
admet-733	47	41	binding	bind	VERB
admet-733	47	42	,	,	PUNCT
admet-733	47	43	used	use	VERB
admet-733	47	44	for	for	ADP
admet-733	47	45	activity	activity	NOUN
admet-733	47	46	and	and	CCONJ
admet-733	47	47	mechanistic	mechanistic	ADJ
admet-733	47	48	assays	assay	NOUN
admet-733	47	49	where	where	SCONJ
admet-733	47	50	atad2	atad2	PROPN
admet-733	47	51	is	be	AUX
admet-733	47	52	atpase	atpase	PROPN
admet-733	47	53	family	family	NOUN
admet-733	47	54	aaa	aaa	NOUN
admet-733	47	55	domain	domain	NOUN
admet-733	47	56	-	-	PUNCT
admet-733	47	57	containing	contain	VERB
admet-733	47	58	protein	protein	NOUN
admet-733	47	59	2	2	NUM
admet-733	47	60	,	,	PUNCT
admet-733	47	61	acper	acper	NOUN
admet-733	47	62	is	be	AUX
admet-733	47	63	acyl	acyl	NOUN
admet-733	47	64	carrier	carrier	NOUN
admet-733	47	65	protein	protein	NOUN
admet-733	47	66	enoyl	enoyl	NOUN
admet-733	47	67	reductase	reductase	NOUN
admet-733	47	68	,	,	PUNCT
admet-733	47	69	mapkapk2	mapkapk2	PROPN
admet-733	47	70	is	be	AUX
admet-733	47	71	mapk	mapk	NOUN
admet-733	47	72	activated	activate	VERB
admet-733	47	73	protein	protein	NOUN
admet-733	47	74	kinase	kinase	NOUN
admet-733	47	75	2	2	X
admet-733	47	76	.	.	PUNCT
admet-733	48	1	the	the	DET
admet-733	48	2	application	application	NOUN
admet-733	48	3	of	of	ADP
admet-733	48	4	biophysics	biophysic	NOUN
admet-733	48	5	to	to	PART
admet-733	48	6	characterise	characterise	VERB
admet-733	48	7	reagent	reagent	ADJ
admet-733	48	8	quality	quality	NOUN
admet-733	48	9	may	may	AUX
admet-733	48	10	not	not	PART
admet-733	48	11	be	be	AUX
admet-733	48	12	a	a	DET
admet-733	48	13	large	large	ADJ
admet-733	48	14	,	,	PUNCT
admet-733	48	15	resource	resource	NOUN
admet-733	48	16	-	-	PUNCT
admet-733	48	17	intensive	intensive	ADJ
admet-733	48	18	effort	effort	NOUN
admet-733	48	19	.	.	PUNCT
admet-733	49	1	often	often	ADV
admet-733	49	2	,	,	PUNCT
admet-733	49	3	a	a	DET
admet-733	49	4	single	single	ADJ
admet-733	49	5	but	but	CCONJ
admet-733	49	6	decisive	decisive	ADJ
admet-733	49	7	experiment	experiment	NOUN
admet-733	49	8	can	can	AUX
admet-733	49	9	be	be	AUX
admet-733	49	10	extremely	extremely	ADV
admet-733	49	11	informative	informative	ADJ
admet-733	49	12	,	,	PUNCT
admet-733	49	13	and	and	CCONJ
admet-733	49	14	often	often	ADV
admet-733	49	15	critical	critical	ADJ
admet-733	49	16	in	in	ADP
admet-733	49	17	understanding	understand	VERB
admet-733	49	18	the	the	DET
admet-733	49	19	behaviour	behaviour	NOUN
admet-733	49	20	of	of	ADP
admet-733	49	21	the	the	DET
admet-733	49	22	target	target	NOUN
admet-733	49	23	protein	protein	NOUN
admet-733	49	24	.	.	PUNCT
admet-733	50	1	additionally	additionally	ADV
admet-733	50	2	,	,	PUNCT
admet-733	50	3	since	since	SCONJ
admet-733	50	4	these	these	DET
admet-733	50	5	methods	method	NOUN
admet-733	50	6	are	be	AUX
admet-733	50	7	often	often	ADV
admet-733	50	8	relatively	relatively	ADV
admet-733	50	9	generic	generic	ADJ
admet-733	50	10	,	,	PUNCT
admet-733	50	11	requiring	require	VERB
admet-733	50	12	little	little	ADJ
admet-733	50	13	assay	assay	NOUN
admet-733	50	14	development	development	NOUN
admet-733	50	15	,	,	PUNCT
admet-733	50	16	their	their	PRON
admet-733	50	17	use	use	NOUN
admet-733	50	18	at	at	ADP
admet-733	50	19	this	this	DET
admet-733	50	20	early	early	ADJ
admet-733	50	21	stage	stage	NOUN
admet-733	50	22	is	be	AUX
admet-733	50	23	not	not	PART
admet-733	50	24	prohibitive	prohibitive	ADJ
admet-733	50	25	,	,	PUNCT
admet-733	50	26	and	and	CCONJ
admet-733	50	27	is	be	AUX
admet-733	50	28	often	often	ADV
admet-733	50	29	influential	influential	ADJ
admet-733	50	30	and	and	CCONJ
admet-733	50	31	impactful	impactful	ADJ
admet-733	50	32	.	.	PUNCT
admet-733	51	1	even	even	ADV
admet-733	51	2	if	if	SCONJ
admet-733	51	3	methods	method	NOUN
admet-733	51	4	do	do	AUX
admet-733	51	5	require	require	VERB
admet-733	51	6	additional	additional	ADJ
admet-733	51	7	development	development	NOUN
admet-733	51	8	time	time	NOUN
admet-733	51	9	,	,	PUNCT
admet-733	51	10	for	for	ADP
admet-733	51	11	example	example	NOUN
admet-733	51	12	spr	spr	ADJ
admet-733	51	13	assays	assay	NOUN
admet-733	51	14	may	may	AUX
admet-733	51	15	take	take	VERB
admet-733	51	16	longer	long	ADJ
admet-733	51	17	to	to	PART
admet-733	51	18	establish	establish	VERB
admet-733	51	19	than	than	ADP
admet-733	51	20	a	a	DET
admet-733	51	21	simple	simple	ADJ
admet-733	51	22	itc	itc	PROPN
admet-733	51	23	experiment	experiment	NOUN
admet-733	51	24	,	,	PUNCT
admet-733	51	25	this	this	PRON
admet-733	51	26	is	be	AUX
admet-733	51	27	usually	usually	ADV
admet-733	51	28	time	time	NOUN
admet-733	51	29	well	well	ADV
admet-733	51	30	invested	invest	VERB
admet-733	51	31	,	,	PUNCT
admet-733	51	32	as	as	SCONJ
admet-733	51	33	the	the	DET
admet-733	51	34	methods	method	NOUN
admet-733	51	35	are	be	AUX
admet-733	51	36	frequently	frequently	ADV
admet-733	51	37	used	use	VERB
admet-733	51	38	again	again	ADV
admet-733	51	39	for	for	ADP
admet-733	51	40	hit	hit	VERB
admet-733	51	41	evaluation	evaluation	NOUN
admet-733	51	42	,	,	PUNCT
admet-733	51	43	and	and	CCONJ
admet-733	51	44	so	so	ADV
admet-733	51	45	the	the	DET
admet-733	51	46	development	development	NOUN
admet-733	51	47	time	time	NOUN
admet-733	51	48	is	be	AUX
admet-733	51	49	in	in	ADP
admet-733	51	50	effect	effect	NOUN
admet-733	51	51	just	just	ADV
admet-733	51	52	positioned	position	VERB
admet-733	51	53	earlier	early	ADV
admet-733	51	54	in	in	ADP
admet-733	51	55	the	the	DET
admet-733	51	56	workflow	workflow	NOUN
admet-733	51	57	than	than	SCONJ
admet-733	51	58	it	it	PRON
admet-733	51	59	otherwise	otherwise	ADV
admet-733	51	60	may	may	AUX
admet-733	51	61	have	have	AUX
admet-733	51	62	been	be	AUX
admet-733	51	63	.	.	PUNCT
admet-733	52	1	in	in	ADP
admet-733	52	2	the	the	DET
admet-733	52	3	case	case	NOUN
admet-733	52	4	of	of	ADP
admet-733	52	5	spr	spr	NOUN
admet-733	52	6	,	,	PUNCT
admet-733	52	7	having	have	VERB
admet-733	52	8	an	an	DET
admet-733	52	9	assay	assay	NOUN
admet-733	52	10	in	in	ADP
admet-733	52	11	place	place	NOUN
admet-733	52	12	to	to	PART
admet-733	52	13	characterise	characterise	NOUN
admet-733	52	14	hits	hit	NOUN
admet-733	52	15	post	post	NOUN
admet-733	52	16	hts	hts	PROPN
admet-733	52	17	is	be	AUX
admet-733	52	18	very	very	ADV
admet-733	52	19	valuable	valuable	ADJ
admet-733	52	20	,	,	PUNCT
admet-733	52	21	and	and	CCONJ
admet-733	52	22	will	will	AUX
admet-733	52	23	be	be	AUX
admet-733	52	24	discussed	discuss	VERB
admet-733	52	25	further	far	ADV
admet-733	52	26	below	below	ADV
admet-733	52	27	.	.	PUNCT
admet-733	53	1	assay	assay	VERB
admet-733	53	2	quality	quality	NOUN
admet-733	53	3	control	control	NOUN
admet-733	53	4	in	in	ADP
admet-733	53	5	addition	addition	NOUN
admet-733	53	6	to	to	ADP
admet-733	53	7	being	be	AUX
admet-733	53	8	able	able	ADJ
admet-733	53	9	to	to	PART
admet-733	53	10	characterise	characterise	VERB
admet-733	53	11	reagents	reagent	NOUN
admet-733	53	12	,	,	PUNCT
admet-733	53	13	biophysical	biophysical	ADJ
admet-733	53	14	methods	method	NOUN
admet-733	53	15	are	be	AUX
admet-733	53	16	also	also	ADV
admet-733	53	17	an	an	DET
admet-733	53	18	invaluable	invaluable	ADJ
admet-733	53	19	tool	tool	NOUN
admet-733	53	20	applied	apply	VERB
admet-733	53	21	to	to	ADP
admet-733	53	22	evaluating	evaluate	VERB
admet-733	53	23	assays	assay	NOUN
admet-733	53	24	for	for	ADP
admet-733	53	25	their	their	PRON
admet-733	53	26	ability	ability	NOUN
admet-733	53	27	to	to	PART
admet-733	53	28	identify	identify	VERB
admet-733	53	29	compounds	compound	NOUN
admet-733	53	30	that	that	PRON
admet-733	53	31	engage	engage	VERB
admet-733	53	32	with	with	ADP
admet-733	53	33	the	the	DET
admet-733	53	34	target	target	NOUN
admet-733	53	35	protein	protein	NOUN
admet-733	53	36	to	to	PART
admet-733	53	37	bring	bring	VERB
admet-733	53	38	about	about	ADP
admet-733	53	39	the	the	DET
admet-733	53	40	desired	desire	VERB
admet-733	53	41	effect	effect	NOUN
admet-733	53	42	.	.	PUNCT
admet-733	54	1	any	any	DET
admet-733	54	2	biochemical	biochemical	ADJ
admet-733	54	3	assay	assay	NOUN
admet-733	54	4	has	have	VERB
admet-733	54	5	the	the	DET
admet-733	54	6	potential	potential	NOUN
admet-733	54	7	for	for	SCONJ
admet-733	54	8	artefacts	artefact	NOUN
admet-733	54	9	to	to	PART
admet-733	54	10	arise	arise	VERB
admet-733	54	11	due	due	ADP
admet-733	54	12	to	to	ADP
admet-733	54	13	nondesired	nondesired	ADJ
admet-733	54	14	mechanisms	mechanism	NOUN
admet-733	54	15	.	.	PUNCT
admet-733	55	1	these	these	PRON
admet-733	55	2	may	may	AUX
admet-733	55	3	be	be	AUX
admet-733	55	4	specific	specific	ADJ
admet-733	55	5	mechanisms	mechanism	NOUN
admet-733	55	6	that	that	PRON
admet-733	55	7	are	be	AUX
admet-733	55	8	unwanted	unwanted	ADJ
admet-733	55	9	in	in	ADP
admet-733	55	10	a	a	DET
admet-733	55	11	drug	drug	NOUN
admet-733	55	12	-	-	PUNCT
admet-733	55	13	like	like	ADJ
admet-733	55	14	compound	compound	NOUN
admet-733	55	15	,	,	PUNCT
admet-733	56	1	such	such	ADJ
admet-733	56	2	holdgate	holdgate	PROPN
admet-733	56	3	et	et	PROPN
admet-733	56	4	al	al	PROPN
admet-733	56	5	.	.	PROPN
admet-733	56	6	admet	admet	PROPN
admet-733	56	7	&	&	CCONJ
admet-733	56	8	dmpk	dmpk	PROPN
admet-733	56	9	7(4	7(4	NUM
admet-733	56	10	)	)	PUNCT
admet-733	56	11	(	(	PUNCT
admet-733	56	12	2019	2019	NUM
admet-733	56	13	)	)	PUNCT
admet-733	56	14	222	222	NUM
admet-733	56	15	-	-	SYM
admet-733	56	16	241	241	NUM
admet-733	56	17	226	226	NUM
admet-733	56	18	as	as	ADP
admet-733	56	19	reactivity	reactivity	NOUN
admet-733	56	20	(	(	PUNCT
admet-733	56	21	for	for	ADP
admet-733	56	22	example	example	NOUN
admet-733	56	23	thiol	thiol	ADJ
admet-733	56	24	reactivity	reactivity	NOUN
admet-733	56	25	)	)	PUNCT
admet-733	56	26	,	,	PUNCT
admet-733	56	27	redox	redox	ADJ
admet-733	56	28	cycling	cycling	NOUN
admet-733	56	29	,	,	PUNCT
admet-733	56	30	colloidal	colloidal	NOUN
admet-733	56	31	aggregation	aggregation	NOUN
admet-733	56	32	,	,	PUNCT
admet-733	56	33	heavy	heavy	ADJ
admet-733	56	34	metal	metal	NOUN
admet-733	56	35	contamination	contamination	NOUN
admet-733	56	36	,	,	PUNCT
admet-733	56	37	protein	protein	NOUN
admet-733	56	38	unfolding	unfolding	NOUN
admet-733	56	39	,	,	PUNCT
admet-733	56	40	protein	protein	NOUN
admet-733	56	41	denaturation	denaturation	NOUN
admet-733	56	42	(	(	PUNCT
admet-733	56	43	so	so	ADV
admet-733	56	44	called	call	VERB
admet-733	56	45	pan	pan	PROPN
admet-733	56	46	assay	assay	PROPN
admet-733	56	47	interference	interference	NOUN
admet-733	56	48	compounds	compound	NOUN
admet-733	56	49	or	or	CCONJ
admet-733	56	50	pains	pain	NOUN
admet-733	56	51	[	[	X
admet-733	56	52	14	14	NUM
admet-733	56	53	]	]	SYM
admet-733	56	54	)	)	PUNCT
admet-733	56	55	or	or	CCONJ
admet-733	56	56	biological	biological	ADJ
admet-733	56	57	system	system	NOUN
admet-733	56	58	or	or	CCONJ
admet-733	56	59	technology	technology	NOUN
admet-733	56	60	interferences	interference	NOUN
admet-733	56	61	,	,	PUNCT
admet-733	56	62	such	such	ADJ
admet-733	56	63	as	as	ADP
admet-733	56	64	coupled	couple	VERB
admet-733	56	65	enzyme	enzyme	NOUN
admet-733	56	66	inhibitors	inhibitor	NOUN
admet-733	56	67	,	,	PUNCT
admet-733	56	68	fluorescent	fluorescent	ADJ
admet-733	56	69	compounds	compound	NOUN
admet-733	56	70	or	or	CCONJ
admet-733	56	71	quenchers	quencher	NOUN
admet-733	56	72	.	.	PUNCT
admet-733	57	1	understanding	understand	VERB
admet-733	57	2	the	the	DET
admet-733	57	3	liability	liability	NOUN
admet-733	57	4	of	of	ADP
admet-733	57	5	a	a	DET
admet-733	57	6	biochemical	biochemical	ADJ
admet-733	57	7	assay	assay	NOUN
admet-733	57	8	to	to	ADP
admet-733	57	9	these	these	DET
admet-733	57	10	types	type	NOUN
admet-733	57	11	of	of	ADP
admet-733	57	12	compounds	compound	NOUN
admet-733	57	13	helps	help	VERB
admet-733	57	14	to	to	PART
admet-733	57	15	understand	understand	VERB
admet-733	57	16	the	the	DET
admet-733	57	17	potential	potential	ADJ
admet-733	57	18	output	output	NOUN
admet-733	57	19	from	from	ADP
admet-733	57	20	high	high	ADJ
admet-733	57	21	-	-	PUNCT
admet-733	57	22	throughput	throughput	NOUN
admet-733	57	23	screens	screen	NOUN
admet-733	57	24	(	(	PUNCT
admet-733	57	25	hts	ht	NOUN
admet-733	57	26	)	)	PUNCT
admet-733	57	27	utilising	utilising	NOUN
admet-733	57	28	that	that	PRON
admet-733	57	29	assay	assay	NOUN
admet-733	57	30	approach	approach	NOUN
admet-733	57	31	.	.	PUNCT
admet-733	58	1	at	at	ADP
admet-733	58	2	astrazeneca	astrazeneca	PROPN
admet-733	58	3	,	,	PUNCT
admet-733	58	4	hts	hts	PROPN
admet-733	58	5	development	development	NOUN
admet-733	58	6	includes	include	VERB
admet-733	58	7	testing	test	VERB
admet-733	58	8	a	a	DET
admet-733	58	9	small	small	ADJ
admet-733	58	10	library	library	NOUN
admet-733	58	11	of	of	ADP
admet-733	58	12	around	around	ADV
admet-733	58	13	1000	1000	NUM
admet-733	58	14	compounds	compound	NOUN
admet-733	58	15	with	with	ADP
admet-733	58	16	unwanted	unwanted	ADJ
admet-733	58	17	mechanism	mechanism	NOUN
admet-733	58	18	of	of	ADP
admet-733	58	19	inhibition	inhibition	NOUN
admet-733	58	20	(	(	PUNCT
admet-733	58	21	the	the	DET
admet-733	58	22	umoi	umoi	PROPN
admet-733	58	23	set	set	NOUN
admet-733	58	24	)	)	PUNCT
admet-733	58	25	and	and	CCONJ
admet-733	58	26	around	around	ADP
admet-733	58	27	7000	7000	NUM
admet-733	58	28	compounds	compound	NOUN
admet-733	58	29	(	(	PUNCT
admet-733	58	30	the	the	DET
admet-733	58	31	validation	validation	NOUN
admet-733	58	32	set	set	NOUN
admet-733	58	33	)	)	PUNCT
admet-733	58	34	,	,	PUNCT
admet-733	58	35	which	which	PRON
admet-733	58	36	are	be	AUX
admet-733	58	37	meant	mean	VERB
admet-733	58	38	to	to	PART
admet-733	58	39	represent	represent	VERB
admet-733	58	40	the	the	DET
admet-733	58	41	diversity	diversity	NOUN
admet-733	58	42	present	present	ADJ
admet-733	58	43	in	in	ADP
admet-733	58	44	the	the	DET
admet-733	58	45	full	full	ADJ
admet-733	58	46	screening	screening	NOUN
admet-733	58	47	set	set	VERB
admet-733	58	48	of	of	ADP
admet-733	58	49	around	around	ADV
admet-733	58	50	2	2	NUM
admet-733	58	51	million	million	NUM
admet-733	58	52	compounds	compound	NOUN
admet-733	58	53	.	.	PUNCT
admet-733	59	1	this	this	PRON
admet-733	59	2	allows	allow	VERB
admet-733	59	3	the	the	DET
admet-733	59	4	assay	assay	NOUN
admet-733	59	5	to	to	PART
admet-733	59	6	be	be	AUX
admet-733	59	7	assessed	assess	VERB
admet-733	59	8	in	in	ADP
admet-733	59	9	terms	term	NOUN
admet-733	59	10	of	of	ADP
admet-733	59	11	its	its	PRON
admet-733	59	12	susceptibility	susceptibility	NOUN
admet-733	59	13	to	to	ADP
admet-733	59	14	pains	pain	NOUN
admet-733	59	15	,	,	PUNCT
admet-733	59	16	as	as	ADV
admet-733	59	17	well	well	ADV
admet-733	59	18	as	as	ADP
admet-733	59	19	providing	provide	VERB
admet-733	59	20	an	an	DET
admet-733	59	21	assessment	assessment	NOUN
admet-733	59	22	of	of	ADP
admet-733	59	23	reproducibility	reproducibility	NOUN
admet-733	59	24	,	,	PUNCT
admet-733	59	25	likely	likely	ADV
admet-733	59	26	hit	hit	VERB
admet-733	59	27	rate	rate	NOUN
admet-733	59	28	and	and	CCONJ
admet-733	59	29	to	to	PART
admet-733	59	30	highlight	highlight	VERB
admet-733	59	31	potential	potential	ADJ
admet-733	59	32	artefacts	artefact	NOUN
admet-733	59	33	and	and	CCONJ
admet-733	59	34	propensity	propensity	NOUN
admet-733	59	35	for	for	ADP
admet-733	59	36	false	false	ADJ
admet-733	59	37	positives	positive	NOUN
admet-733	59	38	and	and	CCONJ
admet-733	59	39	negatives	negative	NOUN
admet-733	59	40	.	.	PUNCT
admet-733	60	1	biophysical	biophysical	ADJ
admet-733	60	2	methods	method	NOUN
admet-733	60	3	such	such	ADJ
admet-733	60	4	as	as	ADP
admet-733	60	5	spr	spr	ADJ
admet-733	60	6	or	or	CCONJ
admet-733	60	7	nmr	nmr	NOUN
admet-733	60	8	are	be	AUX
admet-733	60	9	employed	employ	VERB
admet-733	60	10	following	follow	VERB
admet-733	60	11	this	this	DET
admet-733	60	12	early	early	ADJ
admet-733	60	13	screening	screening	NOUN
admet-733	60	14	activity	activity	NOUN
admet-733	60	15	to	to	PART
admet-733	60	16	characterise	characterise	VERB
admet-733	60	17	the	the	DET
admet-733	60	18	hits	hit	NOUN
admet-733	60	19	,	,	PUNCT
admet-733	60	20	so	so	SCONJ
admet-733	60	21	that	that	SCONJ
admet-733	60	22	the	the	DET
admet-733	60	23	knowledge	knowledge	NOUN
admet-733	60	24	arising	arise	VERB
admet-733	60	25	from	from	ADP
admet-733	60	26	an	an	DET
admet-733	60	27	understanding	understanding	NOUN
admet-733	60	28	of	of	ADP
admet-733	60	29	the	the	DET
admet-733	60	30	reasons	reason	NOUN
admet-733	60	31	behind	behind	ADP
admet-733	60	32	false	false	ADJ
admet-733	60	33	positives	positive	NOUN
admet-733	60	34	may	may	AUX
admet-733	60	35	be	be	AUX
admet-733	60	36	used	use	VERB
admet-733	60	37	to	to	PART
admet-733	60	38	further	far	ADV
admet-733	60	39	optimise	optimise	VERB
admet-733	60	40	the	the	DET
admet-733	60	41	assay	assay	NOUN
admet-733	60	42	to	to	PART
admet-733	60	43	avoid	avoid	VERB
admet-733	60	44	these	these	DET
admet-733	60	45	types	type	NOUN
admet-733	60	46	of	of	ADP
admet-733	60	47	hits	hit	NOUN
admet-733	60	48	in	in	ADP
admet-733	60	49	the	the	DET
admet-733	60	50	full	full	ADJ
admet-733	60	51	screen	screen	NOUN
admet-733	60	52	.	.	PUNCT
admet-733	61	1	table	table	NOUN
admet-733	61	2	3	3	NUM
admet-733	61	3	exemplifies	exemplify	VERB
admet-733	61	4	several	several	ADJ
admet-733	61	5	assays	assay	NOUN
admet-733	61	6	,	,	PUNCT
admet-733	61	7	across	across	ADP
admet-733	61	8	different	different	ADJ
admet-733	61	9	target	target	NOUN
admet-733	61	10	classes	class	NOUN
admet-733	61	11	,	,	PUNCT
admet-733	61	12	where	where	SCONJ
admet-733	61	13	biophysical	biophysical	ADJ
admet-733	61	14	characterisation	characterisation	NOUN
admet-733	61	15	post	post	NOUN
admet-733	61	16	validation	validation	NOUN
admet-733	61	17	set	set	NOUN
admet-733	61	18	testing	testing	NOUN
admet-733	61	19	,	,	PUNCT
admet-733	61	20	influenced	influence	VERB
admet-733	61	21	the	the	DET
admet-733	61	22	subsequent	subsequent	ADJ
admet-733	61	23	hit	hit	NOUN
admet-733	61	24	identification	identification	NOUN
admet-733	61	25	strategy	strategy	NOUN
admet-733	61	26	or	or	CCONJ
admet-733	61	27	tactics	tactic	NOUN
admet-733	61	28	.	.	PUNCT
admet-733	62	1	this	this	DET
admet-733	62	2	workflow	workflow	NOUN
admet-733	62	3	therefore	therefore	ADV
admet-733	62	4	allows	allow	VERB
admet-733	62	5	decisions	decision	NOUN
admet-733	62	6	to	to	PART
admet-733	62	7	be	be	AUX
admet-733	62	8	made	make	VERB
admet-733	62	9	based	base	VERB
admet-733	62	10	on	on	ADP
admet-733	62	11	any	any	DET
admet-733	62	12	specific	specific	ADJ
admet-733	62	13	issues	issue	NOUN
admet-733	62	14	that	that	PRON
admet-733	62	15	arise	arise	VERB
admet-733	62	16	due	due	ADP
admet-733	62	17	to	to	ADP
admet-733	62	18	the	the	DET
admet-733	62	19	nature	nature	NOUN
admet-733	62	20	of	of	ADP
admet-733	62	21	the	the	DET
admet-733	62	22	assay	assay	NOUN
admet-733	62	23	,	,	PUNCT
admet-733	62	24	that	that	PRON
admet-733	62	25	may	may	AUX
admet-733	62	26	be	be	AUX
admet-733	62	27	mitigated	mitigate	VERB
admet-733	62	28	or	or	CCONJ
admet-733	62	29	avoided	avoid	VERB
admet-733	62	30	by	by	ADP
admet-733	62	31	modifying	modify	VERB
admet-733	62	32	the	the	DET
admet-733	62	33	screening	screening	NOUN
admet-733	62	34	cascade	cascade	NOUN
admet-733	62	35	.	.	PUNCT
admet-733	63	1	for	for	ADP
admet-733	63	2	example	example	NOUN
admet-733	63	3	,	,	PUNCT
admet-733	63	4	knowing	know	VERB
admet-733	63	5	that	that	SCONJ
admet-733	63	6	heavy	heavy	ADJ
admet-733	63	7	metals	metal	NOUN
admet-733	63	8	contaminants	contaminant	NOUN
admet-733	63	9	or	or	CCONJ
admet-733	63	10	redox	redox	NOUN
admet-733	63	11	cycling	cycling	NOUN
admet-733	63	12	compounds	compound	NOUN
admet-733	63	13	may	may	AUX
admet-733	63	14	be	be	AUX
admet-733	63	15	hits	hit	NOUN
admet-733	63	16	in	in	ADP
admet-733	63	17	the	the	DET
admet-733	63	18	biochemical	biochemical	ADJ
admet-733	63	19	assay	assay	NOUN
admet-733	63	20	,	,	PUNCT
admet-733	63	21	but	but	CCONJ
admet-733	63	22	the	the	DET
admet-733	63	23	compounds	compound	NOUN
admet-733	63	24	are	be	AUX
admet-733	63	25	not	not	PART
admet-733	63	26	true	true	ADJ
admet-733	63	27	binders	binder	NOUN
admet-733	63	28	to	to	ADP
admet-733	63	29	the	the	DET
admet-733	63	30	target	target	NOUN
admet-733	63	31	protein	protein	NOUN
admet-733	63	32	in	in	ADP
admet-733	63	33	a	a	DET
admet-733	63	34	high	high	ADJ
admet-733	63	35	-	-	PUNCT
admet-733	63	36	fidelity	fidelity	NOUN
admet-733	63	37	biophysical	biophysical	ADJ
admet-733	63	38	method	method	NOUN
admet-733	63	39	allows	allow	VERB
admet-733	63	40	the	the	DET
admet-733	63	41	primary	primary	ADJ
admet-733	63	42	screen	screen	NOUN
admet-733	63	43	to	to	PART
admet-733	63	44	be	be	AUX
admet-733	63	45	modified	modify	VERB
admet-733	63	46	to	to	PART
admet-733	63	47	reduce	reduce	VERB
admet-733	63	48	the	the	DET
admet-733	63	49	liability	liability	NOUN
admet-733	63	50	to	to	ADP
admet-733	63	51	such	such	ADJ
admet-733	63	52	effects	effect	NOUN
admet-733	63	53	.	.	PUNCT
admet-733	64	1	in	in	ADP
admet-733	64	2	these	these	DET
admet-733	64	3	examples	example	NOUN
admet-733	64	4	,	,	PUNCT
admet-733	64	5	the	the	DET
admet-733	64	6	use	use	NOUN
admet-733	64	7	of	of	ADP
admet-733	64	8	metal	metal	NOUN
admet-733	64	9	chelating	chelating	NOUN
admet-733	64	10	agents	agent	NOUN
admet-733	64	11	and	and	CCONJ
admet-733	64	12	investigating	investigate	VERB
admet-733	64	13	different	different	ADJ
admet-733	64	14	reducing	reduce	VERB
admet-733	64	15	agents	agent	NOUN
admet-733	64	16	may	may	AUX
admet-733	64	17	lead	lead	VERB
admet-733	64	18	to	to	ADP
admet-733	64	19	changes	change	NOUN
admet-733	64	20	to	to	ADP
admet-733	64	21	the	the	DET
admet-733	64	22	assay	assay	NOUN
admet-733	64	23	protocol	protocol	NOUN
admet-733	64	24	.	.	PUNCT
admet-733	65	1	alternatively	alternatively	ADV
admet-733	65	2	,	,	PUNCT
admet-733	65	3	post	post	NOUN
admet-733	65	4	screen	screen	NOUN
admet-733	65	5	triage	triage	NOUN
admet-733	65	6	may	may	AUX
admet-733	65	7	involve	involve	VERB
admet-733	65	8	introducing	introduce	VERB
admet-733	65	9	additional	additional	ADJ
admet-733	65	10	assays	assay	NOUN
admet-733	65	11	that	that	PRON
admet-733	65	12	allow	allow	VERB
admet-733	65	13	compounds	compound	NOUN
admet-733	65	14	functioning	function	VERB
admet-733	65	15	by	by	ADP
admet-733	65	16	these	these	DET
admet-733	65	17	undesirable	undesirable	ADJ
admet-733	65	18	mechanisms	mechanism	NOUN
admet-733	65	19	to	to	PART
admet-733	65	20	be	be	AUX
admet-733	65	21	identified	identify	VERB
admet-733	65	22	and	and	CCONJ
admet-733	65	23	deprioritised	deprioritise	VERB
admet-733	65	24	.	.	PUNCT
admet-733	66	1	thus	thus	ADV
admet-733	66	2	,	,	PUNCT
admet-733	66	3	the	the	DET
admet-733	66	4	use	use	NOUN
admet-733	66	5	of	of	ADP
admet-733	66	6	biophysical	biophysical	ADJ
admet-733	66	7	methods	method	NOUN
admet-733	66	8	in	in	ADP
admet-733	66	9	this	this	DET
admet-733	66	10	way	way	NOUN
admet-733	66	11	represents	represent	VERB
admet-733	66	12	a	a	DET
admet-733	66	13	valuable	valuable	ADJ
admet-733	66	14	investment	investment	NOUN
admet-733	66	15	to	to	PART
admet-733	66	16	increase	increase	VERB
admet-733	66	17	the	the	DET
admet-733	66	18	probability	probability	NOUN
admet-733	66	19	that	that	SCONJ
admet-733	66	20	highquality	highquality	NOUN
admet-733	66	21	hits	hit	NOUN
admet-733	66	22	will	will	AUX
admet-733	66	23	be	be	AUX
admet-733	66	24	identified	identify	VERB
admet-733	66	25	during	during	ADP
admet-733	66	26	the	the	DET
admet-733	66	27	primary	primary	ADJ
admet-733	66	28	screen	screen	NOUN
admet-733	66	29	.	.	PUNCT
admet-733	67	1	as	as	SCONJ
admet-733	67	2	can	can	AUX
admet-733	67	3	be	be	AUX
admet-733	67	4	seen	see	VERB
admet-733	67	5	from	from	ADP
admet-733	67	6	table	table	NOUN
admet-733	67	7	3	3	NUM
admet-733	67	8	,	,	PUNCT
admet-733	67	9	in	in	ADP
admet-733	67	10	some	some	DET
admet-733	67	11	cases	case	NOUN
admet-733	67	12	,	,	PUNCT
admet-733	67	13	the	the	DET
admet-733	67	14	impact	impact	NOUN
admet-733	67	15	of	of	ADP
admet-733	67	16	the	the	DET
admet-733	67	17	biophysical	biophysical	ADJ
admet-733	67	18	testing	testing	NOUN
admet-733	67	19	was	be	AUX
admet-733	67	20	taking	take	VERB
admet-733	67	21	a	a	DET
admet-733	67	22	decision	decision	NOUN
admet-733	67	23	not	not	PART
admet-733	67	24	to	to	PART
admet-733	67	25	run	run	VERB
admet-733	67	26	the	the	DET
admet-733	67	27	primary	primary	ADJ
admet-733	67	28	screen	screen	NOUN
admet-733	67	29	at	at	ADV
admet-733	67	30	all	all	ADV
admet-733	67	31	,	,	PUNCT
admet-733	67	32	but	but	CCONJ
admet-733	67	33	to	to	PART
admet-733	67	34	pursue	pursue	VERB
admet-733	67	35	alternative	alternative	ADJ
admet-733	67	36	approaches	approach	NOUN
admet-733	67	37	,	,	PUNCT
admet-733	67	38	such	such	ADJ
admet-733	67	39	as	as	ADP
admet-733	67	40	fragment	fragment	NOUN
admet-733	67	41	-	-	PUNCT
admet-733	67	42	based	base	VERB
admet-733	67	43	lead	lead	NOUN
admet-733	67	44	generation	generation	NOUN
admet-733	67	45	(	(	PUNCT
admet-733	67	46	fblg	fblg	NOUN
admet-733	67	47	)	)	PUNCT
admet-733	67	48	.	.	PUNCT
admet-733	68	1	these	these	DET
admet-733	68	2	decisions	decision	NOUN
admet-733	68	3	,	,	PUNCT
admet-733	68	4	although	although	SCONJ
admet-733	68	5	difficult	difficult	ADJ
admet-733	68	6	at	at	ADP
admet-733	68	7	the	the	DET
admet-733	68	8	time	time	NOUN
admet-733	68	9	,	,	PUNCT
admet-733	68	10	due	due	ADP
admet-733	68	11	to	to	ADP
admet-733	68	12	the	the	DET
admet-733	68	13	previously	previously	ADV
admet-733	68	14	committed	commit	VERB
admet-733	68	15	investment	investment	NOUN
admet-733	68	16	,	,	PUNCT
admet-733	68	17	ultimately	ultimately	ADV
admet-733	68	18	may	may	AUX
admet-733	68	19	result	result	VERB
admet-733	68	20	in	in	ADP
admet-733	68	21	substantial	substantial	ADJ
admet-733	68	22	cost	cost	NOUN
admet-733	68	23	savings	saving	NOUN
admet-733	68	24	,	,	PUNCT
admet-733	68	25	firstly	firstly	ADV
admet-733	68	26	from	from	ADP
admet-733	68	27	not	not	PART
admet-733	68	28	committing	commit	VERB
admet-733	68	29	to	to	ADP
admet-733	68	30	hts	hts	PROPN
admet-733	68	31	(	(	PUNCT
admet-733	68	32	at	at	ADP
admet-733	68	33	an	an	DET
admet-733	68	34	average	average	ADJ
admet-733	68	35	cost	cost	NOUN
admet-733	68	36	of	of	ADP
admet-733	68	37	around	around	ADP
admet-733	68	38	$	$	SYM
admet-733	68	39	90k	90k	NUM
admet-733	68	40	)	)	PUNCT
admet-733	68	41	and	and	CCONJ
admet-733	68	42	secondly	secondly	ADV
admet-733	68	43	from	from	ADP
admet-733	68	44	not	not	PART
admet-733	68	45	following	follow	VERB
admet-733	68	46	up	up	ADP
admet-733	68	47	spurious	spurious	ADJ
admet-733	68	48	hits	hit	NOUN
admet-733	68	49	.	.	PUNCT
admet-733	69	1	figure	figure	NOUN
admet-733	69	2	1	1	NUM
admet-733	69	3	shows	show	VERB
admet-733	69	4	the	the	DET
admet-733	69	5	interplay	interplay	NOUN
admet-733	69	6	that	that	PRON
admet-733	69	7	is	be	AUX
admet-733	69	8	required	require	VERB
admet-733	69	9	between	between	ADP
admet-733	69	10	the	the	DET
admet-733	69	11	assay	assay	NOUN
admet-733	69	12	methodology	methodology	NOUN
admet-733	69	13	,	,	PUNCT
admet-733	69	14	the	the	DET
admet-733	69	15	use	use	NOUN
admet-733	69	16	of	of	ADP
admet-733	69	17	high	high	ADJ
admet-733	69	18	-	-	PUNCT
admet-733	69	19	quality	quality	NOUN
admet-733	69	20	reagents	reagent	NOUN
admet-733	69	21	and	and	CCONJ
admet-733	69	22	the	the	DET
admet-733	69	23	role	role	NOUN
admet-733	69	24	that	that	PRON
admet-733	69	25	biophysics	biophysic	NOUN
admet-733	69	26	has	have	VERB
admet-733	69	27	in	in	ADP
admet-733	69	28	helping	help	VERB
admet-733	69	29	to	to	PART
admet-733	69	30	characterise	characterise	VERB
admet-733	69	31	these	these	DET
admet-733	69	32	aspects	aspect	NOUN
admet-733	69	33	to	to	PART
admet-733	69	34	facilitate	facilitate	VERB
admet-733	69	35	the	the	DET
admet-733	69	36	implementation	implementation	NOUN
admet-733	69	37	of	of	ADP
admet-733	69	38	valid	valid	ADJ
admet-733	69	39	screening	screening	NOUN
admet-733	69	40	assays	assay	NOUN
admet-733	69	41	.	.	PUNCT
admet-733	70	1	primary	primary	ADJ
admet-733	70	2	screening	screening	NOUN
admet-733	70	3	there	there	PRON
admet-733	70	4	are	be	VERB
admet-733	70	5	few	few	ADJ
admet-733	70	6	biophysical	biophysical	ADJ
admet-733	70	7	methods	method	NOUN
admet-733	70	8	that	that	PRON
admet-733	70	9	can	can	AUX
admet-733	70	10	be	be	AUX
admet-733	70	11	applied	apply	VERB
admet-733	70	12	to	to	ADP
admet-733	70	13	primary	primary	ADJ
admet-733	70	14	screening	screening	NOUN
admet-733	70	15	as	as	ADV
admet-733	70	16	usually	usually	ADV
admet-733	70	17	defined	define	VERB
admet-733	70	18	in	in	ADP
admet-733	70	19	the	the	DET
admet-733	70	20	high	high	ADJ
admet-733	70	21	-	-	PUNCT
admet-733	70	22	throughput	throughput	NOUN
admet-733	70	23	setting	setting	NOUN
admet-733	70	24	,	,	PUNCT
admet-733	70	25	which	which	PRON
admet-733	70	26	often	often	ADV
admet-733	70	27	refers	refer	VERB
admet-733	70	28	to	to	ADP
admet-733	70	29	the	the	DET
admet-733	70	30	testing	testing	NOUN
admet-733	70	31	of	of	ADP
admet-733	70	32	1	1	NUM
admet-733	70	33	million	million	NUM
admet-733	70	34	or	or	CCONJ
admet-733	70	35	more	more	ADJ
admet-733	70	36	compounds	compound	NOUN
admet-733	70	37	,	,	PUNCT
admet-733	70	38	and	and	CCONJ
admet-733	70	39	usually	usually	ADV
admet-733	70	40	these	these	DET
admet-733	70	41	methods	method	NOUN
admet-733	70	42	are	be	AUX
admet-733	70	43	more	more	ADV
admet-733	70	44	frequently	frequently	ADV
admet-733	70	45	applied	apply	VERB
admet-733	70	46	for	for	ADP
admet-733	70	47	secondary	secondary	ADJ
admet-733	70	48	hit	hit	NOUN
admet-733	70	49	evaluation	evaluation	NOUN
admet-733	70	50	.	.	PUNCT
admet-733	71	1	the	the	DET
admet-733	71	2	predominate	predominate	ADJ
admet-733	71	3	reasons	reason	NOUN
admet-733	71	4	are	be	AUX
admet-733	71	5	the	the	DET
admet-733	71	6	amount	amount	NOUN
admet-733	71	7	of	of	ADP
admet-733	71	8	protein	protein	NOUN
admet-733	71	9	required	require	VERB
admet-733	71	10	and	and	CCONJ
admet-733	71	11	the	the	DET
admet-733	71	12	throughput	throughput	NOUN
admet-733	71	13	required	require	VERB
admet-733	71	14	to	to	PART
admet-733	71	15	achieve	achieve	VERB
admet-733	71	16	primary	primary	ADJ
admet-733	71	17	screening	screening	NOUN
admet-733	71	18	in	in	ADP
admet-733	71	19	a	a	DET
admet-733	71	20	reasonable	reasonable	ADJ
admet-733	71	21	timeframe	timeframe	NOUN
admet-733	71	22	.	.	PUNCT
admet-733	72	1	to	to	PART
admet-733	72	2	address	address	VERB
admet-733	72	3	these	these	DET
admet-733	72	4	issues	issue	NOUN
admet-733	72	5	compound	compound	NOUN
admet-733	72	6	mixtures	mixture	NOUN
admet-733	72	7	are	be	AUX
admet-733	72	8	often	often	ADV
admet-733	72	9	used	use	VERB
admet-733	72	10	to	to	PART
admet-733	72	11	facilitate	facilitate	VERB
admet-733	72	12	reductions	reduction	NOUN
admet-733	72	13	in	in	ADP
admet-733	72	14	reagents	reagent	NOUN
admet-733	72	15	and	and	CCONJ
admet-733	72	16	time	time	NOUN
admet-733	72	17	,	,	PUNCT
admet-733	72	18	since	since	SCONJ
admet-733	72	19	many	many	ADJ
admet-733	72	20	compounds	compound	NOUN
admet-733	72	21	may	may	AUX
admet-733	72	22	be	be	AUX
admet-733	72	23	screened	screen	VERB
admet-733	72	24	from	from	ADP
admet-733	72	25	a	a	DET
admet-733	72	26	single	single	ADJ
admet-733	72	27	well	well	NOUN
admet-733	72	28	.	.	PUNCT
admet-733	73	1	often	often	ADV
admet-733	73	2	,	,	PUNCT
admet-733	73	3	mixtures	mixture	NOUN
admet-733	73	4	have	have	VERB
admet-733	73	5	no	no	DET
admet-733	73	6	adverse	adverse	ADJ
admet-733	73	7	effects	effect	NOUN
admet-733	73	8	on	on	ADP
admet-733	73	9	the	the	DET
admet-733	73	10	protein	protein	NOUN
admet-733	73	11	,	,	PUNCT
admet-733	73	12	or	or	CCONJ
admet-733	73	13	on	on	ADP
admet-733	73	14	the	the	DET
admet-733	73	15	ability	ability	NOUN
admet-733	73	16	to	to	PART
admet-733	73	17	detect	detect	VERB
admet-733	73	18	binding	bind	VERB
admet-733	73	19	,	,	PUNCT
admet-733	73	20	but	but	CCONJ
admet-733	73	21	sometimes	sometimes	ADV
admet-733	73	22	problems	problem	NOUN
admet-733	73	23	are	be	AUX
admet-733	73	24	experienced	experience	VERB
admet-733	73	25	if	if	SCONJ
admet-733	73	26	there	there	PRON
admet-733	73	27	are	be	VERB
admet-733	73	28	compound	compound	NOUN
admet-733	73	29	-	-	PUNCT
admet-733	73	30	compound	compound	NOUN
admet-733	73	31	interactions	interaction	NOUN
admet-733	73	32	or	or	CCONJ
admet-733	73	33	if	if	SCONJ
admet-733	73	34	the	the	DET
admet-733	73	35	compound	compound	NOUN
admet-733	73	36	organic	organic	ADJ
admet-733	73	37	load	load	NOUN
admet-733	73	38	or	or	CCONJ
admet-733	73	39	the	the	DET
admet-733	73	40	compound	compound	NOUN
admet-733	73	41	solvent	solvent	NOUN
admet-733	73	42	concentration	concentration	NOUN
admet-733	73	43	[	[	X
admet-733	73	44	dmso	dmso	NOUN
admet-733	73	45	]	]	PUNCT
admet-733	73	46	is	be	AUX
admet-733	73	47	too	too	ADV
admet-733	73	48	high	high	ADJ
admet-733	73	49	.	.	PUNCT
admet-733	74	1	admet	admet	PROPN
admet-733	74	2	&	&	CCONJ
admet-733	74	3	dmpk	dmpk	PROPN
admet-733	74	4	7(4	7(4	NUM
admet-733	74	5	)	)	PUNCT
admet-733	74	6	(	(	PUNCT
admet-733	74	7	2019	2019	NUM
admet-733	74	8	)	)	PUNCT
admet-733	74	9	222	222	NUM
admet-733	74	10	-	-	PUNCT
admet-733	74	11	241	241	NUM
admet-733	74	12	biophysical	biophysical	ADJ
admet-733	74	13	methods	method	NOUN
admet-733	74	14	in	in	ADP
admet-733	74	15	early	early	ADJ
admet-733	74	16	drug	drug	NOUN
admet-733	74	17	discovery	discovery	NOUN
admet-733	74	18	doi	doi	PROPN
admet-733	74	19	:	:	PUNCT
admet-733	74	20	10.5599	10.5599	NUM
admet-733	74	21	/	/	SYM
admet-733	74	22	admet.733	admet.733	ADJ
admet-733	74	23	227	227	NUM
admet-733	74	24	table	table	NOUN
admet-733	74	25	3	3	NUM
admet-733	74	26	.	.	PUNCT
admet-733	74	27	impact	impact	NOUN
admet-733	74	28	of	of	ADP
admet-733	74	29	biophysical	biophysical	ADJ
admet-733	74	30	evaluation	evaluation	NOUN
admet-733	74	31	of	of	ADP
admet-733	74	32	hits	hit	NOUN
admet-733	74	33	identified	identify	VERB
admet-733	74	34	during	during	ADP
admet-733	74	35	hts	hts	PROPN
admet-733	74	36	development	development	NOUN
admet-733	74	37	.	.	PUNCT
admet-733	75	1	protein	protein	NOUN
admet-733	75	2	target	target	NOUN
admet-733	75	3	assay	assay	NOUN
admet-733	75	4	methodology	methodology	NOUN
admet-733	75	5	number	number	NOUN
admet-733	75	6	of	of	ADP
admet-733	75	7	compounds	compound	NOUN
admet-733	75	8	tested	test	VERB
admet-733	75	9	biophysical	biophysical	ADJ
admet-733	75	10	methods	method	NOUN
admet-733	75	11	employed	employ	VERB
admet-733	75	12	observations	observation	NOUN
admet-733	75	13	actions	action	NOUN
admet-733	75	14	taken	take	VERB
admet-733	75	15	keap1	keap1	PROPN
admet-733	75	16	htrf	htrf	PROPN
admet-733	75	17	180	180	NUM
admet-733	75	18	nmr	nmr	NOUN
admet-733	75	19	,	,	PUNCT
admet-733	75	20	spr	spr	INTJ
admet-733	76	1	no	no	DET
admet-733	76	2	genuine	genuine	ADJ
admet-733	76	3	hits	hit	NOUN
admet-733	76	4	identified	identify	VERB
admet-733	76	5	hts	hts	PROPN
admet-733	76	6	was	be	AUX
admet-733	76	7	stopped	stop	VERB
admet-733	76	8	and	and	CCONJ
admet-733	76	9	fblg	fblg	VERB
admet-733	76	10	approach	approach	NOUN
admet-733	76	11	used	use	VERB
admet-733	76	12	instead	instead	ADV
admet-733	76	13	malt1	malt1	NOUN
admet-733	76	14	fluorescence	fluorescence	NOUN
admet-733	76	15	intensity	intensity	NOUN
admet-733	76	16	following	follow	VERB
admet-733	76	17	proteolytic	proteolytic	ADJ
admet-733	76	18	cleavage	cleavage	NOUN
admet-733	76	19	60	60	NUM
admet-733	76	20	nmr	nmr	NOUN
admet-733	76	21	17	17	NUM
admet-733	76	22	%	%	NOUN
admet-733	76	23	of	of	ADP
admet-733	76	24	hits	hit	NOUN
admet-733	76	25	showed	show	VERB
admet-733	76	26	specific	specific	ADJ
admet-733	76	27	binding	binding	NOUN
admet-733	76	28	.	.	PUNCT
admet-733	77	1	38	38	NUM
admet-733	77	2	%	%	NOUN
admet-733	77	3	showed	show	VERB
admet-733	77	4	redox	redox	ADJ
admet-733	77	5	cycling	cycling	NOUN
admet-733	77	6	behaviour	behaviour	NOUN
admet-733	77	7	.	.	PUNCT
admet-733	78	1	27	27	NUM
admet-733	78	2	%	%	NOUN
admet-733	78	3	were	be	AUX
admet-733	78	4	not	not	PART
admet-733	78	5	soluble	soluble	ADJ
admet-733	78	6	incorporation	incorporation	NOUN
admet-733	78	7	of	of	ADP
admet-733	78	8	a	a	DET
admet-733	78	9	redox	redox	ADJ
admet-733	78	10	-	-	PUNCT
admet-733	78	11	artefact	artefact	NOUN
admet-733	78	12	assay	assay	NOUN
admet-733	78	13	in	in	ADP
admet-733	78	14	the	the	DET
admet-733	78	15	cascade	cascade	NOUN
admet-733	78	16	reduced	reduce	VERB
admet-733	78	17	the	the	DET
admet-733	78	18	number	number	NOUN
admet-733	78	19	of	of	ADP
admet-733	78	20	redox	redox	ADJ
admet-733	78	21	-	-	PUNCT
admet-733	78	22	active	active	ADJ
admet-733	78	23	compounds	compound	NOUN
admet-733	78	24	reaching	reach	VERB
admet-733	78	25	the	the	DET
admet-733	78	26	nmr	nmr	NOUN
admet-733	78	27	assay	assay	VERB
admet-733	78	28	from	from	ADP
admet-733	78	29	38	38	NUM
admet-733	78	30	%	%	NOUN
admet-733	78	31	to	to	PART
admet-733	78	32	5	5	NUM
admet-733	78	33	%	%	NOUN
admet-733	78	34	errγ	errγ	PROPN
admet-733	78	35	fret	fret	VERB
admet-733	78	36	180	180	NUM
admet-733	78	37	nmr	nmr	NOUN
admet-733	78	38	fret	fret	NOUN
admet-733	78	39	assay	assay	NOUN
admet-733	78	40	suggested	suggest	VERB
admet-733	78	41	that	that	SCONJ
admet-733	78	42	hit	hit	NOUN
admet-733	78	43	rate	rate	NOUN
admet-733	78	44	would	would	AUX
admet-733	78	45	be	be	AUX
admet-733	78	46	low	low	ADJ
admet-733	78	47	.	.	PUNCT
admet-733	79	1	nmr	nmr	NOUN
admet-733	79	2	suggested	suggest	VERB
admet-733	79	3	that	that	SCONJ
admet-733	79	4	90	90	NUM
admet-733	79	5	%	%	NOUN
admet-733	79	6	were	be	AUX
admet-733	79	7	false	false	ADJ
admet-733	79	8	positives	positive	NOUN
admet-733	79	9	hts	ht	NOUN
admet-733	79	10	in	in	ADP
admet-733	79	11	this	this	DET
admet-733	79	12	format	format	NOUN
admet-733	79	13	was	be	AUX
admet-733	79	14	not	not	PART
admet-733	79	15	run	run	VERB
admet-733	79	16	ttbk1	ttbk1	NOUN
admet-733	79	17	adp	adp	PROPN
admet-733	79	18	-	-	PUNCT
admet-733	79	19	glo	glo	PROPN
admet-733	79	20	250	250	NUM
admet-733	79	21	spr	spr	ADJ
admet-733	79	22	69	69	NUM
admet-733	79	23	verified	verify	VERB
admet-733	79	24	hits	hit	NOUN
admet-733	79	25	,	,	PUNCT
admet-733	79	26	then	then	ADV
admet-733	79	27	profiled	profile	VERB
admet-733	79	28	versus	versus	ADP
admet-733	79	29	phosphorylated	phosphorylate	VERB
admet-733	79	30	and	and	CCONJ
admet-733	79	31	non	non	ADJ
admet-733	79	32	-	-	ADJ
admet-733	79	33	phosphorylated	phosphorylate	VERB
admet-733	79	34	protein	protein	NOUN
admet-733	79	35	large	large	ADJ
admet-733	79	36	number	number	NOUN
admet-733	79	37	of	of	ADP
admet-733	79	38	reactive	reactive	ADJ
admet-733	79	39	compounds	compound	NOUN
admet-733	79	40	identified	identify	VERB
admet-733	79	41	adp	adp	PROPN
admet-733	79	42	-	-	PUNCT
admet-733	79	43	glo	glo	PROPN
admet-733	79	44	assay	assay	NOUN
admet-733	79	45	was	be	AUX
admet-733	79	46	not	not	PART
admet-733	79	47	run	run	VERB
admet-733	79	48	acper	acper	ADJ
admet-733	79	49	fluorescence	fluorescence	NOUN
admet-733	79	50	intensity	intensity	NOUN
admet-733	79	51	following	follow	VERB
admet-733	79	52	substrate	substrate	NOUN
admet-733	79	53	turnover	turnover	NOUN
admet-733	79	54	tool	tool	NOUN
admet-733	79	55	compounds	compound	NOUN
admet-733	79	56	and	and	CCONJ
admet-733	79	57	630	630	NUM
admet-733	79	58	fragments	fragment	NOUN
admet-733	79	59	spr	spr	ADJ
admet-733	79	60	,	,	PUNCT
admet-733	79	61	itc	itc	PROPN
admet-733	79	62	characterisation	characterisation	NOUN
admet-733	79	63	demonstrated	demonstrate	VERB
admet-733	79	64	that	that	SCONJ
admet-733	79	65	compounds	compound	NOUN
admet-733	79	66	showing	show	VERB
admet-733	79	67	several	several	ADJ
admet-733	79	68	different	different	ADJ
admet-733	79	69	mechanisms	mechanism	NOUN
admet-733	79	70	of	of	ADP
admet-733	79	71	inhibition	inhibition	NOUN
admet-733	79	72	could	could	AUX
admet-733	79	73	be	be	AUX
admet-733	79	74	found	find	VERB
admet-733	79	75	project	project	NOUN
admet-733	79	76	view	view	NOUN
admet-733	79	77	on	on	ADP
admet-733	79	78	needing	need	VERB
admet-733	79	79	a	a	DET
admet-733	79	80	cofactor	cofactor	NOUN
admet-733	79	81	competitive	competitive	ADJ
admet-733	79	82	inhibitor	inhibitor	NOUN
admet-733	79	83	was	be	AUX
admet-733	79	84	changed	change	VERB
admet-733	79	85	and	and	CCONJ
admet-733	79	86	assays	assay	NOUN
admet-733	79	87	configured	configure	VERB
admet-733	79	88	to	to	PART
admet-733	79	89	find	find	VERB
admet-733	79	90	all	all	DET
admet-733	79	91	mechanisms	mechanism	NOUN
admet-733	79	92	ltc4s	ltc4s	PROPN
admet-733	79	93	htrf	htrf	NOUN
admet-733	79	94	,	,	PUNCT
admet-733	79	95	rapidfire	rapidfire	NOUN
admet-733	79	96	total	total	NOUN
admet-733	79	97	of	of	ADP
admet-733	79	98	50	50	NUM
admet-733	79	99	selected	select	VERB
admet-733	79	100	from	from	ADP
admet-733	79	101	actives	active	NOUN
admet-733	79	102	in	in	ADP
admet-733	79	103	one	one	NUM
admet-733	79	104	or	or	CCONJ
admet-733	79	105	both	both	PRON
admet-733	79	106	assays	assay	NOUN
admet-733	79	107	nmr	nmr	NOUN
admet-733	79	108	,	,	PUNCT
admet-733	79	109	spr	spr	NOUN
admet-733	79	110	77	77	NUM
admet-733	79	111	%	%	NOUN
admet-733	79	112	of	of	ADP
admet-733	79	113	the	the	DET
admet-733	79	114	total	total	ADJ
admet-733	79	115	hits	hit	NOUN
admet-733	79	116	shown	show	VERB
admet-733	79	117	to	to	PART
admet-733	79	118	bind	bind	VERB
admet-733	79	119	and	and	CCONJ
admet-733	79	120	also	also	ADV
admet-733	79	121	to	to	PART
admet-733	79	122	displace	displace	VERB
admet-733	79	123	tool	tool	NOUN
admet-733	79	124	ligand	ligand	NOUN
admet-733	79	125	.	.	PUNCT
admet-733	80	1	confirmation	confirmation	NOUN
admet-733	80	2	rate	rate	NOUN
admet-733	80	3	was	be	AUX
admet-733	80	4	90	90	NUM
admet-733	80	5	%	%	NOUN
admet-733	80	6	for	for	ADP
admet-733	80	7	rapidfire	rapidfire	NOUN
admet-733	80	8	hits	hit	NOUN
admet-733	80	9	,	,	PUNCT
admet-733	80	10	40	40	NUM
admet-733	80	11	%	%	NOUN
admet-733	80	12	for	for	ADP
admet-733	80	13	htrf	htrf	NOUN
admet-733	80	14	hits	hit	VERB
admet-733	80	15	rapidfire	rapidfire	NOUN
admet-733	80	16	assay	assay	PROPN
admet-733	80	17	prioritised	prioritise	VERB
admet-733	80	18	for	for	ADP
admet-733	80	19	full	full	ADJ
admet-733	80	20	hts	ht	NOUN
admet-733	80	21	apc	apc	PROPN
admet-733	80	22	4	4	NUM
admet-733	80	23	different	different	ADJ
admet-733	80	24	assays	assay	NOUN
admet-733	80	25	:	:	PUNCT
admet-733	80	26	1	1	X
admet-733	80	27	)	)	PUNCT
admet-733	80	28	chromogenic	chromogenic	ADJ
admet-733	80	29	cleavage	cleavage	NOUN
admet-733	80	30	2	2	NUM
admet-733	80	31	)	)	PUNCT
admet-733	80	32	peptide	peptide	NOUN
admet-733	80	33	cleavage	cleavage	NOUN
admet-733	80	34	coupled	couple	VERB
admet-733	80	35	assay	assay	PROPN
admet-733	80	36	3	3	NUM
admet-733	80	37	)	)	PUNCT
admet-733	80	38	peptide	peptide	NOUN
admet-733	80	39	cleavage	cleavage	NOUN
admet-733	80	40	rapidfire	rapidfire	NOUN
admet-733	80	41	4	4	NUM
admet-733	80	42	)	)	PUNCT
admet-733	80	43	fibrin	fibrin	NOUN
admet-733	80	44	clot	clot	NOUN
admet-733	80	45	assay	assay	NOUN
admet-733	80	46	total	total	NOUN
admet-733	80	47	of	of	ADP
admet-733	80	48	250	250	NUM
admet-733	80	49	identified	identify	VERB
admet-733	80	50	from	from	ADP
admet-733	80	51	the	the	DET
admet-733	80	52	assays	assay	NOUN
admet-733	80	53	as	as	SCONJ
admet-733	80	54	follows	follow	VERB
admet-733	80	55	:	:	PUNCT
admet-733	80	56	1	1	NUM
admet-733	80	57	)	)	PUNCT
admet-733	80	58	90	90	NUM
admet-733	80	59	2	2	NUM
admet-733	80	60	)	)	PUNCT
admet-733	80	61	50	50	NUM
admet-733	80	62	3	3	NUM
admet-733	80	63	)	)	PUNCT
admet-733	80	64	10	10	NUM
admet-733	80	65	4	4	NUM
admet-733	80	66	)	)	PUNCT
admet-733	80	67	100	100	NUM
admet-733	80	68	190	190	NUM
admet-733	80	69	selected	select	VERB
admet-733	80	70	for	for	ADP
admet-733	80	71	biophysical	biophysical	ADJ
admet-733	80	72	testing	testing	NOUN
admet-733	80	73	(	(	PUNCT
admet-733	80	74	90	90	NUM
admet-733	80	75	from	from	ADP
admet-733	80	76	assays	assay	NOUN
admet-733	80	77	1	1	NUM
admet-733	80	78	-	-	SYM
admet-733	80	79	3	3	NUM
admet-733	80	80	and	and	CCONJ
admet-733	80	81	total	total	ADJ
admet-733	80	82	output	output	NOUN
admet-733	80	83	from	from	ADP
admet-733	80	84	4	4	NUM
admet-733	80	85	spr	spr	ADJ
admet-733	80	86	,	,	PUNCT
admet-733	80	87	nmr	nmr	NOUN
admet-733	80	88	numbers	number	NOUN
admet-733	80	89	of	of	ADP
admet-733	80	90	confirmed	confirm	VERB
admet-733	80	91	hits	hit	NOUN
admet-733	80	92	originating	originate	VERB
admet-733	80	93	from	from	ADP
admet-733	80	94	each	each	DET
admet-733	80	95	assay	assay	NOUN
admet-733	80	96	approach	approach	NOUN
admet-733	80	97	:	:	PUNCT
admet-733	80	98	1	1	NUM
admet-733	80	99	)	)	PUNCT
admet-733	80	100	8	8	NUM
admet-733	80	101	2	2	NUM
admet-733	80	102	)	)	PUNCT
admet-733	80	103	16	16	NUM
admet-733	80	104	3	3	NUM
admet-733	80	105	)	)	PUNCT
admet-733	80	106	9	9	NUM
admet-733	80	107	4	4	NUM
admet-733	80	108	)	)	PUNCT
admet-733	80	109	13	13	NUM
admet-733	80	110	fibrin	fibrin	NOUN
admet-733	80	111	clot	clot	NOUN
admet-733	80	112	assay	assay	NOUN
admet-733	80	113	was	be	AUX
admet-733	80	114	shown	show	VERB
admet-733	80	115	to	to	PART
admet-733	80	116	identify	identify	VERB
admet-733	80	117	compounds	compound	NOUN
admet-733	80	118	binding	bind	VERB
admet-733	80	119	at	at	ADP
admet-733	80	120	a	a	DET
admet-733	80	121	site	site	NOUN
admet-733	80	122	distal	distal	NOUN
admet-733	80	123	from	from	ADP
admet-733	80	124	the	the	DET
admet-733	80	125	active	active	ADJ
admet-733	80	126	site	site	NOUN
admet-733	80	127	fibrin	fibrin	NOUN
admet-733	80	128	clot	clot	NOUN
admet-733	80	129	assay	assay	NOUN
admet-733	80	130	was	be	AUX
admet-733	80	131	selected	select	VERB
admet-733	80	132	for	for	ADP
admet-733	80	133	hts	hts	PROPN
admet-733	80	134	,	,	PUNCT
admet-733	80	135	based	base	VERB
admet-733	80	136	on	on	ADP
admet-733	80	137	the	the	DET
admet-733	80	138	ability	ability	NOUN
admet-733	80	139	to	to	PART
admet-733	80	140	identify	identify	VERB
admet-733	80	141	novel	novel	NOUN
admet-733	80	142	,	,	PUNCT
admet-733	80	143	exo	exo	NOUN
admet-733	80	144	site	site	NOUN
admet-733	80	145	binders	binder	NOUN
admet-733	80	146	.	.	PUNCT
admet-733	81	1	where	where	SCONJ
admet-733	81	2	keap1	keap1	NOUN
admet-733	81	3	is	be	AUX
admet-733	81	4	kelch	kelch	ADJ
admet-733	81	5	like	like	ADP
admet-733	81	6	ech	ech	PROPN
admet-733	81	7	associated	associate	VERB
admet-733	81	8	protein	protein	NOUN
admet-733	81	9	1	1	NUM
admet-733	81	10	,	,	PUNCT
admet-733	81	11	malt1	malt1	NOUN
admet-733	81	12	is	be	AUX
admet-733	81	13	mucosa	mucosa	NOUN
admet-733	81	14	-	-	PUNCT
admet-733	81	15	associated	associate	VERB
admet-733	81	16	lymphoid	lymphoid	ADJ
admet-733	81	17	tissue	tissue	NOUN
admet-733	81	18	lymphoma	lymphoma	NOUN
admet-733	81	19	translocation	translocation	NOUN
admet-733	81	20	protein	protein	NOUN
admet-733	81	21	1	1	NUM
admet-733	81	22	,	,	PUNCT
admet-733	81	23	errγ	errγ	PROPN
admet-733	81	24	is	be	AUX
admet-733	81	25	estrogen	estrogen	NOUN
admet-733	81	26	-	-	PUNCT
admet-733	81	27	related	relate	VERB
admet-733	81	28	receptor	receptor	NOUN
admet-733	81	29	gamma	gamma	NOUN
admet-733	81	30	,	,	PUNCT
admet-733	81	31	ttbk1	ttbk1	NOUN
admet-733	81	32	is	be	AUX
admet-733	81	33	tau	tau	PROPN
admet-733	81	34	tubulin	tubulin	PROPN
admet-733	81	35	kinase	kinase	NOUN
admet-733	81	36	1	1	NUM
admet-733	81	37	,	,	PUNCT
admet-733	81	38	acper	acper	NOUN
admet-733	81	39	is	be	AUX
admet-733	81	40	acyl	acyl	NOUN
admet-733	81	41	carrier	carrier	NOUN
admet-733	81	42	protein	protein	NOUN
admet-733	81	43	enoyl	enoyl	NOUN
admet-733	81	44	reductase	reductase	NOUN
admet-733	81	45	,	,	PUNCT
admet-733	81	46	ltc4s	ltc4s	PROPN
admet-733	81	47	is	be	AUX
admet-733	81	48	leukotriene	leukotriene	NOUN
admet-733	81	49	c4	c4	NOUN
admet-733	81	50	synthase	synthase	NOUN
admet-733	81	51	and	and	CCONJ
admet-733	81	52	apc	apc	PROPN
admet-733	81	53	is	be	AUX
admet-733	81	54	activated	activate	VERB
admet-733	81	55	protein	protein	NOUN
admet-733	81	56	c.	c.	NOUN
admet-733	81	57	two	two	NUM
admet-733	81	58	biophysical	biophysical	ADJ
admet-733	81	59	methods	method	NOUN
admet-733	81	60	that	that	PRON
admet-733	81	61	are	be	AUX
admet-733	81	62	often	often	ADV
admet-733	81	63	capable	capable	ADJ
admet-733	81	64	of	of	ADP
admet-733	81	65	providing	provide	VERB
admet-733	81	66	throughputs	throughput	NOUN
admet-733	81	67	approaching	approach	VERB
admet-733	81	68	that	that	PRON
admet-733	81	69	of	of	ADP
admet-733	81	70	traditional	traditional	ADJ
admet-733	81	71	hts	ht	NOUN
admet-733	81	72	are	be	AUX
admet-733	81	73	affinity	affinity	NOUN
admet-733	81	74	selection	selection	NOUN
admet-733	81	75	mass	mass	NOUN
admet-733	81	76	spectrometry	spectrometry	NOUN
admet-733	81	77	(	(	PUNCT
admet-733	81	78	as	as	ADP
admet-733	81	79	-	-	PUNCT
admet-733	81	80	ms	ms	NOUN
admet-733	81	81	)	)	PUNCT
admet-733	82	1	[	[	X
admet-733	82	2	15	15	NUM
admet-733	82	3	]	]	PUNCT
admet-733	82	4	and	and	CCONJ
admet-733	82	5	thermal	thermal	ADJ
admet-733	82	6	shift	shift	NOUN
admet-733	82	7	assays	assay	NOUN
admet-733	82	8	(	(	PUNCT
admet-733	82	9	tsa	tsa	PROPN
admet-733	82	10	)	)	PUNCT
admet-733	83	1	[	[	X
admet-733	83	2	16	16	NUM
admet-733	83	3	]	]	PUNCT
admet-733	83	4	.	.	PUNCT
admet-733	84	1	these	these	DET
admet-733	84	2	methods	method	NOUN
admet-733	84	3	utilise	utilise	VERB
admet-733	84	4	mass	mass	ADJ
admet-733	84	5	detection	detection	NOUN
admet-733	84	6	of	of	ADP
admet-733	84	7	ligands	ligand	NOUN
admet-733	84	8	bound	bind	VERB
admet-733	84	9	to	to	ADP
admet-733	84	10	a	a	DET
admet-733	84	11	target	target	NOUN
admet-733	84	12	protein	protein	NOUN
admet-733	84	13	and	and	CCONJ
admet-733	84	14	the	the	DET
admet-733	84	15	ligand	ligand	NOUN
admet-733	84	16	-	-	PUNCT
admet-733	84	17	induced	induce	VERB
admet-733	84	18	increase	increase	NOUN
admet-733	84	19	in	in	ADP
admet-733	84	20	thermal	thermal	ADJ
admet-733	84	21	stability	stability	NOUN
admet-733	84	22	respectively	respectively	ADV
admet-733	84	23	to	to	PART
admet-733	84	24	identify	identify	VERB
admet-733	84	25	hits	hit	NOUN
admet-733	84	26	.	.	PUNCT
admet-733	85	1	the	the	DET
admet-733	85	2	benefit	benefit	NOUN
admet-733	85	3	of	of	ADP
admet-733	85	4	these	these	DET
admet-733	85	5	approaches	approach	NOUN
admet-733	85	6	in	in	ADP
admet-733	85	7	primary	primary	ADJ
admet-733	85	8	screening	screening	NOUN
admet-733	85	9	is	be	AUX
admet-733	85	10	that	that	SCONJ
admet-733	85	11	the	the	DET
admet-733	85	12	assay	assay	NOUN
admet-733	85	13	is	be	AUX
admet-733	85	14	generic	generic	ADJ
admet-733	85	15	and	and	CCONJ
admet-733	85	16	can	can	AUX
admet-733	85	17	rapidly	rapidly	ADV
admet-733	85	18	be	be	AUX
admet-733	85	19	optimised	optimise	VERB
admet-733	85	20	for	for	ADP
admet-733	85	21	the	the	DET
admet-733	85	22	target	target	NOUN
admet-733	85	23	of	of	ADP
admet-733	85	24	interest	interest	NOUN
admet-733	85	25	.	.	PUNCT
admet-733	86	1	the	the	DET
admet-733	86	2	disadvantage	disadvantage	NOUN
admet-733	86	3	in	in	ADP
admet-733	86	4	biophysical	biophysical	ADJ
admet-733	86	5	primary	primary	ADJ
admet-733	86	6	screening	screening	NOUN
admet-733	86	7	is	be	AUX
admet-733	86	8	that	that	SCONJ
admet-733	86	9	identified	identify	VERB
admet-733	86	10	hits	hit	NOUN
admet-733	86	11	may	may	AUX
admet-733	86	12	bind	bind	VERB
admet-733	86	13	to	to	ADP
admet-733	86	14	the	the	DET
admet-733	86	15	target	target	NOUN
admet-733	86	16	protein	protein	NOUN
admet-733	86	17	but	but	CCONJ
admet-733	86	18	may	may	AUX
admet-733	86	19	not	not	PART
admet-733	86	20	have	have	VERB
admet-733	86	21	the	the	DET
admet-733	86	22	desired	desire	VERB
admet-733	86	23	biological	biological	ADJ
admet-733	86	24	effect	effect	NOUN
admet-733	86	25	.	.	PUNCT
admet-733	87	1	an	an	DET
admet-733	87	2	alternative	alternative	ADJ
admet-733	87	3	use	use	NOUN
admet-733	87	4	of	of	ADP
admet-733	87	5	biophysical	biophysical	ADJ
admet-733	87	6	methods	method	NOUN
admet-733	87	7	in	in	ADP
admet-733	87	8	primary	primary	ADJ
admet-733	87	9	screening	screening	NOUN
admet-733	87	10	is	be	AUX
admet-733	87	11	in	in	ADP
admet-733	87	12	testing	test	VERB
admet-733	87	13	a	a	DET
admet-733	87	14	much	much	ADV
admet-733	87	15	smaller	small	ADJ
admet-733	87	16	library	library	NOUN
admet-733	87	17	of	of	ADP
admet-733	87	18	low	low	ADJ
admet-733	87	19	molecular	molecular	ADJ
admet-733	87	20	weight	weight	NOUN
admet-733	87	21	compounds	compound	NOUN
admet-733	87	22	in	in	ADP
admet-733	87	23	so	so	ADV
admet-733	87	24	-	-	PUNCT
admet-733	87	25	called	call	VERB
admet-733	87	26	fragment	fragment	NOUN
admet-733	87	27	-	-	PUNCT
admet-733	87	28	based	base	VERB
admet-733	87	29	screening	screening	NOUN
admet-733	87	30	[	[	X
admet-733	87	31	17	17	NUM
admet-733	87	32	]	]	PUNCT
admet-733	87	33	.	.	PUNCT
admet-733	88	1	this	this	PRON
admet-733	88	2	was	be	AUX
admet-733	88	3	first	first	ADV
admet-733	88	4	described	describe	VERB
admet-733	88	5	holdgate	holdgate	PROPN
admet-733	88	6	et	et	PROPN
admet-733	88	7	al	al	PROPN
admet-733	88	8	.	.	PROPN
admet-733	88	9	admet	admet	PROPN
admet-733	88	10	&	&	CCONJ
admet-733	88	11	dmpk	dmpk	PROPN
admet-733	88	12	7(4	7(4	NUM
admet-733	88	13	)	)	PUNCT
admet-733	88	14	(	(	PUNCT
admet-733	88	15	2019	2019	NUM
admet-733	88	16	)	)	PUNCT
admet-733	88	17	222	222	NUM
admet-733	88	18	-	-	SYM
admet-733	88	19	241	241	NUM
admet-733	88	20	228	228	NUM
admet-733	88	21	employing	employ	VERB
admet-733	88	22	nmr	nmr	NOUN
admet-733	88	23	screening	screen	VERB
admet-733	88	24	to	to	PART
admet-733	88	25	identify	identify	VERB
admet-733	88	26	fragments	fragment	NOUN
admet-733	88	27	that	that	PRON
admet-733	88	28	could	could	AUX
admet-733	88	29	subsequently	subsequently	ADV
admet-733	88	30	be	be	AUX
admet-733	88	31	linked	link	VERB
admet-733	88	32	and	and	CCONJ
admet-733	88	33	optimised	optimise	VERB
admet-733	88	34	to	to	PART
admet-733	88	35	make	make	VERB
admet-733	88	36	higher	high	ADJ
admet-733	88	37	affinity	affinity	NOUN
admet-733	88	38	compounds	compound	NOUN
admet-733	88	39	[	[	X
admet-733	88	40	4	4	NUM
admet-733	88	41	]	]	PUNCT
admet-733	88	42	.	.	PUNCT
admet-733	89	1	more	more	ADV
admet-733	89	2	recently	recently	ADV
admet-733	89	3	,	,	PUNCT
admet-733	89	4	fragment	fragment	ADJ
admet-733	89	5	screening	screening	NOUN
admet-733	89	6	has	have	AUX
admet-733	89	7	been	be	AUX
admet-733	89	8	described	describe	VERB
admet-733	89	9	by	by	ADP
admet-733	89	10	other	other	ADJ
admet-733	89	11	biophysical	biophysical	ADJ
admet-733	89	12	methods	method	NOUN
admet-733	89	13	including	include	VERB
admet-733	89	14	both	both	DET
admet-733	89	15	spr	spr	NOUN
admet-733	90	1	[	[	X
admet-733	90	2	18	18	NUM
admet-733	90	3	]	]	PUNCT
admet-733	90	4	and	and	CCONJ
admet-733	90	5	tsa	tsa	NOUN
admet-733	90	6	[	[	X
admet-733	90	7	19	19	NUM
admet-733	90	8	]	]	PUNCT
admet-733	90	9	.	.	PUNCT
admet-733	91	1	figure	figure	NOUN
admet-733	91	2	1	1	NUM
admet-733	91	3	.	.	PUNCT
admet-733	91	4	interplay	interplay	NOUN
admet-733	91	5	between	between	ADP
admet-733	91	6	reagents	reagent	NOUN
admet-733	91	7	,	,	PUNCT
admet-733	91	8	assay	assay	NOUN
admet-733	91	9	methodology	methodology	NOUN
admet-733	91	10	and	and	CCONJ
admet-733	91	11	biophysical	biophysical	ADJ
admet-733	91	12	quality	quality	NOUN
admet-733	91	13	control	control	NOUN
admet-733	91	14	in	in	ADP
admet-733	91	15	the	the	DET
admet-733	91	16	development	development	NOUN
admet-733	91	17	of	of	ADP
admet-733	91	18	valid	valid	ADJ
admet-733	91	19	assays	assay	NOUN
admet-733	91	20	.	.	PUNCT
admet-733	92	1	high	high	ADJ
admet-733	92	2	-	-	PUNCT
admet-733	92	3	throughput	throughput	NOUN
admet-733	92	4	screening	screening	NOUN
admet-733	92	5	–	–	PUNCT
admet-733	92	6	affinity	affinity	NOUN
admet-733	92	7	selection	selection	NOUN
admet-733	92	8	mass	mass	NOUN
admet-733	92	9	spectrometry	spectrometry	NOUN
admet-733	92	10	(	(	PUNCT
admet-733	92	11	as	as	ADP
admet-733	92	12	-	-	PUNCT
admet-733	92	13	ms	ms	NOUN
admet-733	92	14	)	)	PUNCT
admet-733	93	1	the	the	DET
admet-733	93	2	application	application	NOUN
admet-733	93	3	of	of	ADP
admet-733	93	4	mass	mass	ADJ
admet-733	93	5	spectrometry	spectrometry	NOUN
admet-733	93	6	(	(	PUNCT
admet-733	93	7	ms	ms	PROPN
admet-733	93	8	)	)	PUNCT
admet-733	93	9	in	in	ADP
admet-733	93	10	the	the	DET
admet-733	93	11	drug	drug	NOUN
admet-733	93	12	discovery	discovery	NOUN
admet-733	93	13	process	process	NOUN
admet-733	93	14	has	have	AUX
admet-733	93	15	been	be	AUX
admet-733	93	16	well	well	ADV
admet-733	93	17	established	establish	VERB
admet-733	93	18	for	for	ADP
admet-733	93	19	many	many	ADJ
admet-733	93	20	years	year	NOUN
admet-733	93	21	.	.	PUNCT
admet-733	94	1	it	it	PRON
admet-733	94	2	has	have	AUX
admet-733	94	3	been	be	AUX
admet-733	94	4	applied	apply	VERB
admet-733	94	5	both	both	PRON
admet-733	94	6	in	in	ADP
admet-733	94	7	the	the	DET
admet-733	94	8	characterisation	characterisation	NOUN
admet-733	94	9	of	of	ADP
admet-733	94	10	target	target	NOUN
admet-733	94	11	proteins	protein	NOUN
admet-733	94	12	,	,	PUNCT
admet-733	94	13	where	where	SCONJ
admet-733	94	14	it	it	PRON
admet-733	94	15	has	have	AUX
admet-733	94	16	been	be	AUX
admet-733	94	17	primarily	primarily	ADV
admet-733	94	18	focussed	focusse	VERB
admet-733	94	19	on	on	ADP
admet-733	94	20	quality	quality	NOUN
admet-733	94	21	control	control	NOUN
admet-733	94	22	as	as	ADV
admet-733	94	23	well	well	ADV
admet-733	94	24	as	as	ADP
admet-733	94	25	target	target	NOUN
admet-733	94	26	identification	identification	NOUN
admet-733	94	27	and	and	CCONJ
admet-733	94	28	validation	validation	NOUN
admet-733	94	29	.	.	PUNCT
admet-733	95	1	for	for	ADP
admet-733	95	2	small	small	ADJ
admet-733	95	3	molecules	molecule	NOUN
admet-733	95	4	,	,	PUNCT
admet-733	95	5	the	the	DET
admet-733	95	6	technique	technique	NOUN
admet-733	95	7	has	have	AUX
admet-733	95	8	been	be	AUX
admet-733	95	9	used	use	VERB
admet-733	95	10	for	for	ADP
admet-733	95	11	metabolism	metabolism	NOUN
admet-733	95	12	and	and	CCONJ
admet-733	95	13	pharmacokinetics	pharmacokinetic	NOUN
admet-733	95	14	studies	study	NOUN
admet-733	95	15	as	as	ADP
admet-733	95	16	compound	compound	NOUN
admet-733	95	17	identification	identification	NOUN
admet-733	95	18	.	.	PUNCT
admet-733	96	1	more	more	ADV
admet-733	96	2	recently	recently	ADV
admet-733	96	3	,	,	PUNCT
admet-733	96	4	ms	ms	PROPN
admet-733	96	5	approaches	approach	NOUN
admet-733	96	6	have	have	AUX
admet-733	96	7	been	be	AUX
admet-733	96	8	developed	develop	VERB
admet-733	96	9	to	to	PART
admet-733	96	10	detect	detect	VERB
admet-733	96	11	and	and	CCONJ
admet-733	96	12	characterise	characterise	VERB
admet-733	96	13	protein	protein	NOUN
admet-733	96	14	-	-	PUNCT
admet-733	96	15	small	small	ADJ
admet-733	96	16	molecule	molecule	NOUN
admet-733	96	17	complexes	complex	NOUN
admet-733	96	18	.	.	PUNCT
admet-733	97	1	affinity	affinity	NOUN
admet-733	97	2	selection	selection	NOUN
admet-733	97	3	mass	mass	NOUN
admet-733	97	4	spectrometry	spectrometry	NOUN
admet-733	97	5	(	(	PUNCT
admet-733	97	6	as	as	ADP
admet-733	97	7	-	-	PUNCT
admet-733	97	8	ms	ms	NOUN
admet-733	97	9	)	)	PUNCT
admet-733	97	10	is	be	AUX
admet-733	97	11	now	now	ADV
admet-733	97	12	the	the	DET
admet-733	97	13	predominant	predominant	ADJ
admet-733	97	14	biophysical	biophysical	ADJ
admet-733	97	15	method	method	NOUN
admet-733	97	16	used	use	VERB
admet-733	97	17	for	for	ADP
admet-733	97	18	primary	primary	ADJ
admet-733	97	19	screening	screening	NOUN
admet-733	97	20	.	.	PUNCT
admet-733	98	1	it	it	PRON
admet-733	98	2	was	be	AUX
admet-733	98	3	first	first	ADV
admet-733	98	4	introduced	introduce	VERB
admet-733	98	5	in	in	ADP
admet-733	98	6	the	the	DET
admet-733	98	7	late	late	ADJ
admet-733	98	8	1990s	1990	NOUN
admet-733	98	9	[	[	X
admet-733	98	10	20	20	NUM
admet-733	98	11	]	]	PUNCT
admet-733	98	12	and	and	CCONJ
admet-733	98	13	various	various	ADJ
admet-733	98	14	formats	format	NOUN
admet-733	98	15	have	have	AUX
admet-733	98	16	been	be	AUX
admet-733	98	17	described	describe	VERB
admet-733	98	18	,	,	PUNCT
admet-733	98	19	evaluated	evaluate	VERB
admet-733	98	20	and	and	CCONJ
admet-733	98	21	implemented	implement	VERB
admet-733	98	22	since	since	SCONJ
admet-733	98	23	then	then	ADV
admet-733	98	24	[	[	X
admet-733	98	25	21	21	NUM
admet-733	98	26	]	]	PUNCT
admet-733	98	27	.	.	PUNCT
admet-733	99	1	however	however	ADV
admet-733	99	2	,	,	PUNCT
admet-733	99	3	the	the	DET
admet-733	99	4	basic	basic	ADJ
admet-733	99	5	premise	premise	NOUN
admet-733	99	6	of	of	ADP
admet-733	99	7	all	all	DET
admet-733	99	8	these	these	DET
admet-733	99	9	methods	method	NOUN
admet-733	99	10	is	be	AUX
admet-733	99	11	the	the	DET
admet-733	99	12	detection	detection	NOUN
admet-733	99	13	of	of	ADP
admet-733	99	14	compounds	compound	NOUN
admet-733	99	15	that	that	PRON
admet-733	99	16	bind	bind	VERB
admet-733	99	17	to	to	ADP
admet-733	99	18	the	the	DET
admet-733	99	19	target	target	NOUN
admet-733	99	20	protein	protein	NOUN
admet-733	99	21	using	use	VERB
admet-733	99	22	mass	mass	ADJ
admet-733	99	23	detection	detection	NOUN
admet-733	99	24	of	of	ADP
admet-733	99	25	the	the	DET
admet-733	99	26	bound	bind	VERB
admet-733	99	27	ligand	ligand	NOUN
admet-733	99	28	.	.	PUNCT
admet-733	100	1	this	this	DET
admet-733	100	2	simple	simple	ADJ
admet-733	100	3	binding	bind	VERB
admet-733	100	4	assay	assay	NOUN
admet-733	100	5	has	have	VERB
admet-733	100	6	the	the	DET
admet-733	100	7	benefit	benefit	NOUN
admet-733	100	8	of	of	ADP
admet-733	100	9	reduced	reduced	ADJ
admet-733	100	10	interference	interference	NOUN
admet-733	100	11	,	,	PUNCT
admet-733	100	12	since	since	SCONJ
admet-733	100	13	there	there	PRON
admet-733	100	14	is	be	VERB
admet-733	100	15	no	no	DET
admet-733	100	16	requirement	requirement	NOUN
admet-733	100	17	for	for	ADP
admet-733	100	18	functional	functional	ADJ
admet-733	100	19	activity	activity	NOUN
admet-733	100	20	which	which	PRON
admet-733	100	21	often	often	ADV
admet-733	100	22	entails	entail	VERB
admet-733	100	23	more	more	ADV
admet-733	100	24	complex	complex	ADJ
admet-733	100	25	assays	assay	NOUN
admet-733	100	26	and	and	CCONJ
admet-733	100	27	therefore	therefore	ADV
admet-733	100	28	often	often	ADV
admet-733	100	29	increased	increase	VERB
admet-733	100	30	probability	probability	NOUN
admet-733	100	31	of	of	ADP
admet-733	100	32	artefacts	artefact	NOUN
admet-733	100	33	arising	arise	VERB
admet-733	100	34	due	due	ADP
admet-733	100	35	to	to	ADP
admet-733	100	36	effects	effect	NOUN
admet-733	100	37	on	on	ADP
admet-733	100	38	the	the	DET
admet-733	100	39	read	read	NOUN
admet-733	100	40	-	-	PUNCT
admet-733	100	41	out	out	NOUN
admet-733	100	42	,	,	PUNCT
admet-733	100	43	rather	rather	ADV
admet-733	100	44	than	than	ADP
admet-733	100	45	from	from	ADP
admet-733	100	46	true	true	ADJ
admet-733	100	47	target	target	NOUN
admet-733	100	48	engagement	engagement	NOUN
admet-733	100	49	.	.	PUNCT
admet-733	101	1	another	another	DET
admet-733	101	2	advantage	advantage	NOUN
admet-733	101	3	is	be	AUX
admet-733	101	4	that	that	SCONJ
admet-733	101	5	this	this	DET
admet-733	101	6	screening	screening	NOUN
admet-733	101	7	approach	approach	NOUN
admet-733	101	8	can	can	AUX
admet-733	101	9	be	be	AUX
admet-733	101	10	applied	apply	VERB
admet-733	101	11	to	to	AUX
admet-733	101	12	orphan	orphan	VERB
admet-733	101	13	genomic	genomic	NOUN
admet-733	101	14	targets	target	NOUN
admet-733	101	15	and	and	CCONJ
admet-733	101	16	targets	target	NOUN
admet-733	101	17	for	for	ADP
admet-733	101	18	which	which	PRON
admet-733	101	19	functional	functional	ADJ
admet-733	101	20	assays	assay	NOUN
admet-733	101	21	can	can	AUX
admet-733	101	22	not	not	PART
admet-733	101	23	be	be	AUX
admet-733	101	24	developed	develop	VERB
admet-733	101	25	.	.	PUNCT
admet-733	102	1	the	the	DET
admet-733	102	2	major	major	ADJ
admet-733	102	3	disadvantage	disadvantage	NOUN
admet-733	102	4	,	,	PUNCT
admet-733	102	5	alongside	alongside	ADP
admet-733	102	6	the	the	DET
admet-733	102	7	requirement	requirement	NOUN
admet-733	102	8	,	,	PUNCT
admet-733	102	9	mentioned	mention	VERB
admet-733	102	10	above	above	ADV
admet-733	102	11	,	,	PUNCT
admet-733	102	12	for	for	ADP
admet-733	102	13	assessing	assess	VERB
admet-733	102	14	functional	functional	ADJ
admet-733	102	15	activity	activity	NOUN
admet-733	102	16	post	post	NOUN
admet-733	102	17	-	-	NOUN
admet-733	102	18	screen	screen	NOUN
admet-733	102	19	,	,	PUNCT
admet-733	102	20	is	be	AUX
admet-733	102	21	that	that	SCONJ
admet-733	102	22	these	these	DET
admet-733	102	23	methods	method	NOUN
admet-733	102	24	are	be	AUX
admet-733	102	25	not	not	PART
admet-733	102	26	commercially	commercially	ADV
admet-733	102	27	available	available	ADJ
admet-733	102	28	and	and	CCONJ
admet-733	102	29	systems	system	NOUN
admet-733	102	30	,	,	PUNCT
admet-733	102	31	expertise	expertise	NOUN
admet-733	102	32	and	and	CCONJ
admet-733	102	33	sometimes	sometimes	ADV
admet-733	102	34	even	even	ADV
admet-733	102	35	the	the	DET
admet-733	102	36	software	software	NOUN
admet-733	102	37	solutions	solution	NOUN
admet-733	102	38	required	require	VERB
admet-733	102	39	for	for	ADP
admet-733	102	40	data	datum	NOUN
admet-733	102	41	analysis	analysis	NOUN
admet-733	102	42	have	have	VERB
admet-733	102	43	to	to	PART
admet-733	102	44	be	be	AUX
admet-733	102	45	developed	develop	VERB
admet-733	102	46	in	in	ADP
admet-733	102	47	house	house	NOUN
admet-733	102	48	.	.	PUNCT
admet-733	103	1	although	although	SCONJ
admet-733	103	2	there	there	PRON
admet-733	103	3	are	be	VERB
admet-733	103	4	subtle	subtle	ADJ
admet-733	103	5	differences	difference	NOUN
admet-733	103	6	in	in	ADP
admet-733	103	7	the	the	DET
admet-733	103	8	way	way	NOUN
admet-733	103	9	as	as	SCONJ
admet-733	103	10	-	-	PUNCT
admet-733	103	11	ms	ms	NOUN
admet-733	103	12	methods	method	NOUN
admet-733	103	13	may	may	AUX
admet-733	103	14	be	be	AUX
admet-733	103	15	employed	employ	VERB
admet-733	103	16	,	,	PUNCT
admet-733	103	17	the	the	DET
admet-733	103	18	principle	principle	NOUN
admet-733	103	19	of	of	ADP
admet-733	103	20	the	the	DET
admet-733	103	21	different	different	ADJ
admet-733	103	22	approaches	approach	NOUN
admet-733	103	23	is	be	AUX
admet-733	103	24	essentially	essentially	ADV
admet-733	103	25	the	the	DET
admet-733	103	26	same	same	ADJ
admet-733	103	27	.	.	PUNCT
admet-733	104	1	it	it	PRON
admet-733	104	2	involves	involve	VERB
admet-733	104	3	incubating	incubate	VERB
admet-733	104	4	a	a	DET
admet-733	104	5	library	library	NOUN
admet-733	104	6	of	of	ADP
admet-733	104	7	small	small	ADJ
admet-733	104	8	molecule	molecule	NOUN
admet-733	104	9	compound	compound	NOUN
admet-733	104	10	mixtures	mixture	NOUN
admet-733	104	11	with	with	ADP
admet-733	104	12	the	the	DET
admet-733	104	13	target	target	NOUN
admet-733	104	14	protein	protein	NOUN
admet-733	104	15	,	,	PUNCT
admet-733	104	16	separating	separate	VERB
admet-733	104	17	the	the	DET
admet-733	104	18	bound	bind	VERB
admet-733	104	19	small	small	ADJ
admet-733	104	20	molecules	molecule	NOUN
admet-733	104	21	from	from	ADP
admet-733	104	22	non	non	ADJ
admet-733	104	23	-	-	NOUN
admet-733	104	24	binders	binder	NOUN
admet-733	104	25	and	and	CCONJ
admet-733	104	26	detecting	detect	VERB
admet-733	104	27	those	those	DET
admet-733	104	28	binders	binder	NOUN
admet-733	104	29	using	use	VERB
admet-733	104	30	mass	mass	ADJ
admet-733	104	31	spectrometry	spectrometry	NOUN
admet-733	104	32	,	,	PUNCT
admet-733	104	33	figure	figure	NOUN
admet-733	104	34	2	2	NUM
admet-733	104	35	.	.	PUNCT
admet-733	105	1	the	the	DET
admet-733	105	2	relatively	relatively	ADV
admet-733	105	3	slow	slow	ADJ
admet-733	105	4	ms	ms	NOUN
admet-733	105	5	detection	detection	NOUN
admet-733	105	6	still	still	ADV
admet-733	105	7	limits	limit	VERB
admet-733	105	8	the	the	DET
admet-733	105	9	throughput	throughput	NOUN
admet-733	105	10	of	of	ADP
admet-733	105	11	these	these	DET
admet-733	105	12	methods	method	NOUN
admet-733	105	13	and	and	CCONJ
admet-733	105	14	even	even	ADV
admet-733	105	15	with	with	ADP
admet-733	105	16	the	the	DET
admet-733	105	17	development	development	NOUN
admet-733	105	18	of	of	ADP
admet-733	105	19	acoustic	acoustic	ADJ
admet-733	105	20	mist	mist	NOUN
admet-733	105	21	ionisation	ionisation	NOUN
admet-733	105	22	approaches	approach	VERB
admet-733	105	23	[	[	X
admet-733	105	24	22	22	NUM
admet-733	105	25	]	]	PUNCT
admet-733	105	26	,	,	PUNCT
admet-733	105	27	which	which	PRON
admet-733	105	28	have	have	AUX
admet-733	105	29	increased	increase	VERB
admet-733	105	30	the	the	DET
admet-733	105	31	speed	speed	NOUN
admet-733	105	32	of	of	ADP
admet-733	105	33	mass	mass	ADJ
admet-733	105	34	spectrometry	spectrometry	NOUN
admet-733	105	35	detection	detection	NOUN
admet-733	105	36	,	,	PUNCT
admet-733	105	37	large	large	ADJ
admet-733	105	38	compound	compound	NOUN
admet-733	105	39	mixtures	mixture	NOUN
admet-733	105	40	are	be	AUX
admet-733	105	41	still	still	ADV
admet-733	105	42	required	require	VERB
admet-733	105	43	with	with	ADP
admet-733	105	44	mixture	mixture	NOUN
admet-733	105	45	sizes	size	NOUN
admet-733	105	46	ranging	range	VERB
admet-733	105	47	from	from	ADP
admet-733	105	48	around	around	ADP
admet-733	105	49	admet	admet	PROPN
admet-733	105	50	&	&	CCONJ
admet-733	105	51	dmpk	dmpk	PROPN
admet-733	105	52	7(4	7(4	NUM
admet-733	105	53	)	)	PUNCT
admet-733	105	54	(	(	PUNCT
admet-733	105	55	2019	2019	NUM
admet-733	105	56	)	)	PUNCT
admet-733	105	57	222	222	NUM
admet-733	105	58	-	-	PUNCT
admet-733	105	59	241	241	NUM
admet-733	105	60	biophysical	biophysical	ADJ
admet-733	105	61	methods	method	NOUN
admet-733	105	62	in	in	ADP
admet-733	105	63	early	early	ADJ
admet-733	105	64	drug	drug	NOUN
admet-733	105	65	discovery	discovery	NOUN
admet-733	105	66	doi	doi	PROPN
admet-733	105	67	:	:	PUNCT
admet-733	105	68	10.5599	10.5599	NUM
admet-733	105	69	/	/	SYM
admet-733	105	70	admet.733	admet.733	ADJ
admet-733	105	71	229	229	NUM
admet-733	105	72	100	100	NUM
admet-733	105	73	to	to	ADP
admet-733	105	74	almost	almost	ADV
admet-733	105	75	3000	3000	NUM
admet-733	105	76	compound	compound	NOUN
admet-733	105	77	per	per	ADP
admet-733	105	78	well	well	ADV
admet-733	105	79	.	.	PUNCT
admet-733	106	1	consideration	consideration	NOUN
admet-733	106	2	of	of	ADP
admet-733	106	3	the	the	DET
admet-733	106	4	composition	composition	NOUN
admet-733	106	5	of	of	ADP
admet-733	106	6	these	these	DET
admet-733	106	7	mixtures	mixture	NOUN
admet-733	106	8	is	be	AUX
admet-733	106	9	important	important	ADJ
admet-733	106	10	as	as	SCONJ
admet-733	106	11	these	these	DET
admet-733	106	12	mixtures	mixture	NOUN
admet-733	106	13	have	have	VERB
admet-733	106	14	potential	potential	NOUN
admet-733	106	15	for	for	ADP
admet-733	106	16	introducing	introduce	VERB
admet-733	106	17	solubility	solubility	NOUN
admet-733	106	18	issues	issue	NOUN
admet-733	106	19	,	,	PUNCT
admet-733	106	20	compound	compound	NOUN
admet-733	106	21	-	-	PUNCT
admet-733	106	22	compound	compound	NOUN
admet-733	106	23	reactivity	reactivity	NOUN
admet-733	106	24	and	and	CCONJ
admet-733	106	25	instability	instability	NOUN
admet-733	106	26	.	.	PUNCT
admet-733	107	1	smaller	small	ADJ
admet-733	107	2	mixtures	mixture	NOUN
admet-733	107	3	are	be	AUX
admet-733	107	4	clearly	clearly	ADV
admet-733	107	5	less	less	ADV
admet-733	107	6	disposed	disposed	ADJ
admet-733	107	7	to	to	ADP
admet-733	107	8	these	these	DET
admet-733	107	9	types	type	NOUN
admet-733	107	10	of	of	ADP
admet-733	107	11	problems	problem	NOUN
admet-733	107	12	but	but	CCONJ
admet-733	107	13	may	may	AUX
admet-733	107	14	impose	impose	VERB
admet-733	107	15	restrictions	restriction	NOUN
admet-733	107	16	on	on	ADP
admet-733	107	17	the	the	DET
admet-733	107	18	size	size	NOUN
admet-733	107	19	of	of	ADP
admet-733	107	20	the	the	DET
admet-733	107	21	compound	compound	NOUN
admet-733	107	22	library	library	NOUN
admet-733	107	23	that	that	PRON
admet-733	107	24	be	be	AUX
admet-733	107	25	screened	screen	VERB
admet-733	107	26	.	.	PUNCT
admet-733	108	1	whilst	whilst	SCONJ
admet-733	108	2	this	this	DET
admet-733	108	3	method	method	NOUN
admet-733	108	4	is	be	AUX
admet-733	108	5	not	not	PART
admet-733	108	6	dependent	dependent	ADJ
admet-733	108	7	upon	upon	SCONJ
admet-733	108	8	protein	protein	NOUN
admet-733	108	9	function	function	NOUN
admet-733	108	10	,	,	PUNCT
admet-733	108	11	ms	ms	PROPN
admet-733	108	12	has	have	VERB
admet-733	108	13	a	a	DET
admet-733	108	14	low	low	ADJ
admet-733	108	15	tolerance	tolerance	NOUN
admet-733	108	16	to	to	ADP
admet-733	108	17	detergents	detergent	NOUN
admet-733	108	18	present	present	ADJ
admet-733	108	19	in	in	ADP
admet-733	108	20	biological	biological	ADJ
admet-733	108	21	buffers	buffer	NOUN
admet-733	108	22	.	.	PUNCT
admet-733	109	1	this	this	PRON
admet-733	109	2	is	be	AUX
admet-733	109	3	primarily	primarily	ADV
admet-733	109	4	due	due	ADJ
admet-733	109	5	to	to	ADP
admet-733	109	6	the	the	DET
admet-733	109	7	propensity	propensity	NOUN
admet-733	109	8	for	for	ADP
admet-733	109	9	large	large	ADJ
admet-733	109	10	aggregates	aggregate	NOUN
admet-733	109	11	to	to	PART
admet-733	109	12	form	form	VERB
admet-733	109	13	which	which	PRON
admet-733	109	14	may	may	AUX
admet-733	109	15	interfere	interfere	VERB
admet-733	109	16	with	with	ADP
admet-733	109	17	binding	bind	VERB
admet-733	109	18	and	and	CCONJ
admet-733	109	19	detection	detection	NOUN
admet-733	109	20	.	.	PUNCT
admet-733	110	1	thus	thus	ADV
admet-733	110	2	,	,	PUNCT
admet-733	110	3	the	the	DET
admet-733	110	4	application	application	NOUN
admet-733	110	5	is	be	AUX
admet-733	110	6	limited	limit	VERB
admet-733	110	7	to	to	ADP
admet-733	110	8	screening	screen	VERB
admet-733	110	9	soluble	soluble	ADJ
admet-733	110	10	proteins	protein	NOUN
admet-733	110	11	as	as	SCONJ
admet-733	110	12	the	the	DET
admet-733	110	13	detergents	detergent	NOUN
admet-733	110	14	required	require	VERB
admet-733	110	15	for	for	ADP
admet-733	110	16	membrane	membrane	NOUN
admet-733	110	17	protein	protein	NOUN
admet-733	110	18	preparations	preparation	NOUN
admet-733	110	19	are	be	AUX
admet-733	110	20	not	not	PART
admet-733	110	21	compatible	compatible	ADJ
admet-733	110	22	.	.	PUNCT
admet-733	111	1	figure	figure	NOUN
admet-733	111	2	2	2	NUM
admet-733	111	3	.	.	PUNCT
admet-733	111	4	schematic	schematic	ADJ
admet-733	111	5	representation	representation	NOUN
admet-733	111	6	of	of	ADP
admet-733	111	7	the	the	DET
admet-733	111	8	workflow	workflow	NOUN
admet-733	111	9	for	for	ADP
admet-733	111	10	as	as	ADP
admet-733	111	11	-	-	PUNCT
admet-733	111	12	ms	ms	NOUN
admet-733	111	13	primary	primary	ADJ
admet-733	111	14	screening	screening	NOUN
admet-733	111	15	.	.	PUNCT
admet-733	112	1	mixtures	mixture	NOUN
admet-733	112	2	of	of	ADP
admet-733	112	3	test	test	NOUN
admet-733	112	4	compound	compound	NOUN
admet-733	112	5	are	be	AUX
admet-733	112	6	incubated	incubate	VERB
admet-733	112	7	with	with	ADP
admet-733	112	8	the	the	DET
admet-733	112	9	target	target	NOUN
admet-733	112	10	protein	protein	NOUN
admet-733	112	11	before	before	ADP
admet-733	112	12	separation	separation	NOUN
admet-733	112	13	of	of	ADP
admet-733	112	14	bound	bind	VERB
admet-733	112	15	ligands	ligand	NOUN
admet-733	112	16	from	from	ADP
admet-733	112	17	free	free	ADJ
admet-733	112	18	ligands	ligand	NOUN
admet-733	112	19	by	by	ADP
admet-733	112	20	size	size	NOUN
admet-733	112	21	plate	plate	NOUN
admet-733	112	22	-	-	PUNCT
admet-733	112	23	based	base	VERB
admet-733	112	24	exclusion	exclusion	NOUN
admet-733	112	25	chromatography	chromatography	NOUN
admet-733	112	26	.	.	PUNCT
admet-733	113	1	bound	bind	VERB
admet-733	113	2	ligands	ligand	NOUN
admet-733	113	3	,	,	PUNCT
admet-733	113	4	which	which	PRON
admet-733	113	5	are	be	AUX
admet-733	113	6	eluted	elute	VERB
admet-733	113	7	with	with	ADP
admet-733	113	8	the	the	DET
admet-733	113	9	target	target	NOUN
admet-733	113	10	protein	protein	NOUN
admet-733	113	11	,	,	PUNCT
admet-733	113	12	are	be	AUX
admet-733	113	13	subsequently	subsequently	ADV
admet-733	113	14	detected	detect	VERB
admet-733	113	15	by	by	ADP
admet-733	113	16	mass	mass	ADJ
admet-733	113	17	spectrometry	spectrometry	NOUN
admet-733	113	18	.	.	PUNCT
admet-733	114	1	even	even	ADV
admet-733	114	2	with	with	ADP
admet-733	114	3	these	these	DET
admet-733	114	4	limitations	limitation	NOUN
admet-733	114	5	,	,	PUNCT
admet-733	114	6	as	as	SCONJ
admet-733	114	7	-	-	PUNCT
admet-733	114	8	ms	ms	NOUN
admet-733	114	9	still	still	ADV
admet-733	114	10	represents	represent	VERB
admet-733	114	11	an	an	DET
admet-733	114	12	important	important	ADJ
admet-733	114	13	addition	addition	NOUN
admet-733	114	14	to	to	ADP
admet-733	114	15	the	the	DET
admet-733	114	16	high	high	ADJ
admet-733	114	17	-	-	PUNCT
admet-733	114	18	throughput	throughput	NOUN
admet-733	114	19	screening	screening	NOUN
admet-733	114	20	toolbox	toolbox	NOUN
admet-733	114	21	.	.	PUNCT
admet-733	115	1	the	the	DET
admet-733	115	2	sensitivity	sensitivity	NOUN
admet-733	115	3	means	mean	VERB
admet-733	115	4	that	that	SCONJ
admet-733	115	5	relatively	relatively	ADV
admet-733	115	6	low	low	ADJ
admet-733	115	7	amounts	amount	NOUN
admet-733	115	8	of	of	ADP
admet-733	115	9	target	target	NOUN
admet-733	115	10	protein	protein	NOUN
admet-733	115	11	are	be	AUX
admet-733	115	12	required	require	VERB
admet-733	115	13	,	,	PUNCT
admet-733	115	14	of	of	ADP
admet-733	115	15	course	course	NOUN
admet-733	115	16	there	there	PRON
admet-733	115	17	is	be	VERB
admet-733	115	18	no	no	DET
admet-733	115	19	requirement	requirement	NOUN
admet-733	115	20	for	for	ADP
admet-733	115	21	labelling	labelling	NOUN
admet-733	115	22	of	of	ADP
admet-733	115	23	reagents	reagent	NOUN
admet-733	115	24	and	and	CCONJ
admet-733	115	25	the	the	DET
admet-733	115	26	process	process	NOUN
admet-733	115	27	can	can	AUX
admet-733	115	28	be	be	AUX
admet-733	115	29	automated	automate	VERB
admet-733	115	30	,	,	PUNCT
admet-733	115	31	all	all	PRON
admet-733	115	32	features	feature	VERB
admet-733	115	33	that	that	PRON
admet-733	115	34	contribute	contribute	VERB
admet-733	115	35	to	to	ADP
admet-733	115	36	the	the	DET
admet-733	115	37	quality	quality	NOUN
admet-733	115	38	,	,	PUNCT
admet-733	115	39	speed	speed	NOUN
admet-733	115	40	and	and	CCONJ
admet-733	115	41	cost	cost	NOUN
admet-733	115	42	considerations	consideration	NOUN
admet-733	115	43	required	require	VERB
admet-733	115	44	when	when	SCONJ
admet-733	115	45	deciding	decide	VERB
admet-733	115	46	upon	upon	SCONJ
admet-733	115	47	a	a	DET
admet-733	115	48	primary	primary	ADJ
admet-733	115	49	screening	screening	NOUN
admet-733	115	50	approach	approach	NOUN
admet-733	115	51	.	.	PUNCT
admet-733	116	1	high	high	ADJ
admet-733	116	2	-	-	PUNCT
admet-733	116	3	throughput	throughput	NOUN
admet-733	116	4	screening	screening	NOUN
admet-733	116	5	–	–	PUNCT
admet-733	116	6	thermal	thermal	ADJ
admet-733	116	7	shift	shift	NOUN
admet-733	116	8	assay	assay	PROPN
admet-733	116	9	(	(	PUNCT
admet-733	116	10	tsa	tsa	PROPN
admet-733	116	11	)	)	PUNCT
admet-733	116	12	the	the	DET
admet-733	116	13	thermal	thermal	ADJ
admet-733	116	14	shift	shift	NOUN
admet-733	116	15	assay	assay	PROPN
admet-733	116	16	(	(	PUNCT
admet-733	116	17	tsa	tsa	PROPN
admet-733	116	18	)	)	PUNCT
admet-733	116	19	also	also	ADV
admet-733	116	20	known	know	VERB
admet-733	116	21	as	as	ADP
admet-733	116	22	thermofluor	thermofluor	NOUN
admet-733	116	23	or	or	CCONJ
admet-733	116	24	differential	differential	NOUN
admet-733	116	25	scanning	scanning	NOUN
admet-733	116	26	fluorimetry	fluorimetry	NOUN
admet-733	116	27	has	have	AUX
admet-733	116	28	been	be	AUX
admet-733	116	29	used	use	VERB
admet-733	116	30	for	for	ADP
admet-733	116	31	several	several	ADJ
admet-733	116	32	years	year	NOUN
admet-733	116	33	to	to	PART
admet-733	116	34	study	study	VERB
admet-733	116	35	protein	protein	NOUN
admet-733	116	36	stability	stability	NOUN
admet-733	116	37	[	[	X
admet-733	116	38	23	23	NUM
admet-733	116	39	]	]	PUNCT
admet-733	116	40	.	.	PUNCT
admet-733	117	1	it	it	PRON
admet-733	117	2	is	be	AUX
admet-733	117	3	a	a	DET
admet-733	117	4	rapid	rapid	ADJ
admet-733	117	5	and	and	CCONJ
admet-733	117	6	simple	simple	ADJ
admet-733	117	7	method	method	NOUN
admet-733	117	8	that	that	PRON
admet-733	117	9	allows	allow	VERB
admet-733	117	10	the	the	DET
admet-733	117	11	melting	melting	NOUN
admet-733	117	12	temperature	temperature	NOUN
admet-733	117	13	,	,	PUNCT
admet-733	117	14	tm	tm	X
admet-733	117	15	(	(	PUNCT
admet-733	117	16	temperature	temperature	NOUN
admet-733	117	17	at	at	ADP
admet-733	117	18	which	which	PRON
admet-733	117	19	50	50	NUM
admet-733	117	20	%	%	NOUN
admet-733	117	21	of	of	ADP
admet-733	117	22	the	the	DET
admet-733	117	23	protein	protein	NOUN
admet-733	117	24	is	be	AUX
admet-733	117	25	unfolded	unfold	VERB
admet-733	117	26	)	)	PUNCT
admet-733	117	27	,	,	PUNCT
admet-733	117	28	to	to	PART
admet-733	117	29	be	be	AUX
admet-733	117	30	determined	determine	VERB
admet-733	117	31	under	under	ADP
admet-733	117	32	different	different	ADJ
admet-733	117	33	conditions	condition	NOUN
admet-733	117	34	.	.	PUNCT
admet-733	118	1	it	it	PRON
admet-733	118	2	has	have	AUX
admet-733	118	3	extensively	extensively	ADV
admet-733	118	4	been	be	AUX
admet-733	118	5	used	use	VERB
admet-733	118	6	to	to	PART
admet-733	118	7	optimise	optimise	VERB
admet-733	118	8	buffer	buffer	NOUN
admet-733	118	9	conditions	condition	NOUN
admet-733	118	10	for	for	ADP
admet-733	118	11	x	x	NOUN
admet-733	118	12	-	-	NOUN
admet-733	118	13	ray	ray	NOUN
admet-733	118	14	crystallographic	crystallographic	ADJ
admet-733	118	15	studies	study	NOUN
admet-733	118	16	on	on	ADP
admet-733	118	17	soluble	soluble	ADJ
admet-733	118	18	proteins	protein	NOUN
admet-733	118	19	,	,	PUNCT
admet-733	118	20	such	such	ADJ
admet-733	118	21	that	that	SCONJ
admet-733	118	22	those	those	DET
admet-733	118	23	conditions	condition	NOUN
admet-733	118	24	yielding	yield	VERB
admet-733	118	25	the	the	DET
admet-733	118	26	highest	high	ADJ
admet-733	118	27	stability	stability	NOUN
admet-733	118	28	may	may	AUX
admet-733	118	29	be	be	AUX
admet-733	118	30	used	use	VERB
admet-733	118	31	as	as	ADP
admet-733	118	32	start	start	NOUN
admet-733	118	33	points	point	NOUN
admet-733	118	34	for	for	ADP
admet-733	118	35	crystallisation	crystallisation	NOUN
admet-733	118	36	trials	trial	NOUN
admet-733	118	37	.	.	PUNCT
admet-733	119	1	the	the	DET
admet-733	119	2	addition	addition	NOUN
admet-733	119	3	of	of	ADP
admet-733	119	4	compounds	compound	NOUN
admet-733	119	5	that	that	PRON
admet-733	119	6	bind	bind	VERB
admet-733	119	7	to	to	ADP
admet-733	119	8	the	the	DET
admet-733	119	9	target	target	NOUN
admet-733	119	10	protein	protein	NOUN
admet-733	119	11	,	,	PUNCT
admet-733	119	12	thermodynamically	thermodynamically	ADV
admet-733	119	13	stabilise	stabilise	VERB
admet-733	119	14	the	the	DET
admet-733	119	15	protein	protein	NOUN
admet-733	119	16	relative	relative	ADJ
admet-733	119	17	to	to	ADP
admet-733	119	18	controls	control	NOUN
admet-733	119	19	in	in	ADP
admet-733	119	20	the	the	DET
admet-733	119	21	absence	absence	NOUN
admet-733	119	22	of	of	ADP
admet-733	119	23	ligand	ligand	NOUN
admet-733	119	24	,	,	PUNCT
admet-733	119	25	and	and	CCONJ
admet-733	119	26	this	this	DET
admet-733	119	27	stabilisation	stabilisation	NOUN
admet-733	119	28	can	can	AUX
admet-733	119	29	be	be	AUX
admet-733	119	30	used	use	VERB
admet-733	119	31	to	to	PART
admet-733	119	32	identify	identify	VERB
admet-733	119	33	binders	binder	NOUN
admet-733	119	34	from	from	ADP
admet-733	119	35	non	non	NOUN
admet-733	119	36	-	-	NOUN
admet-733	119	37	binders	binder	NOUN
admet-733	119	38	.	.	PUNCT
admet-733	120	1	the	the	DET
admet-733	120	2	tsa	tsa	PROPN
admet-733	120	3	experiment	experiment	NOUN
admet-733	120	4	involves	involve	VERB
admet-733	120	5	incubating	incubate	VERB
admet-733	120	6	the	the	DET
admet-733	120	7	target	target	NOUN
admet-733	120	8	protein	protein	NOUN
admet-733	120	9	with	with	ADP
admet-733	120	10	test	test	NOUN
admet-733	120	11	compounds	compound	NOUN
admet-733	120	12	in	in	ADP
admet-733	120	13	the	the	DET
admet-733	120	14	presence	presence	NOUN
admet-733	120	15	of	of	ADP
admet-733	120	16	a	a	DET
admet-733	120	17	dye	dye	NOUN
admet-733	120	18	that	that	PRON
admet-733	120	19	binds	bind	VERB
admet-733	120	20	to	to	ADP
admet-733	120	21	hydrophobic	hydrophobic	NOUN
admet-733	120	22	regions	region	NOUN
admet-733	120	23	of	of	ADP
admet-733	120	24	the	the	DET
admet-733	120	25	protein	protein	NOUN
admet-733	120	26	.	.	PUNCT
admet-733	121	1	the	the	DET
admet-733	121	2	temperature	temperature	NOUN
admet-733	121	3	is	be	AUX
admet-733	121	4	then	then	ADV
admet-733	121	5	increased	increase	VERB
admet-733	121	6	uniformly	uniformly	ADV
admet-733	121	7	,	,	PUNCT
admet-733	121	8	and	and	CCONJ
admet-733	121	9	the	the	DET
admet-733	121	10	fluorescence	fluorescence	NOUN
admet-733	121	11	of	of	ADP
admet-733	121	12	dye	dye	NOUN
admet-733	121	13	monitored	monitor	VERB
admet-733	121	14	with	with	ADP
admet-733	121	15	temperature	temperature	NOUN
admet-733	121	16	.	.	PUNCT
admet-733	122	1	as	as	SCONJ
admet-733	122	2	the	the	DET
admet-733	122	3	protein	protein	NOUN
admet-733	122	4	unfolds	unfold	VERB
admet-733	122	5	more	more	ADJ
admet-733	122	6	hydrophobic	hydrophobic	ADJ
admet-733	122	7	regions	region	NOUN
admet-733	122	8	are	be	AUX
admet-733	122	9	holdgate	holdgate	NOUN
admet-733	122	10	et	et	PROPN
admet-733	122	11	al	al	PROPN
admet-733	122	12	.	.	PROPN
admet-733	122	13	admet	admet	PROPN
admet-733	122	14	&	&	CCONJ
admet-733	122	15	dmpk	dmpk	PROPN
admet-733	122	16	7(4	7(4	NUM
admet-733	122	17	)	)	PUNCT
admet-733	122	18	(	(	PUNCT
admet-733	122	19	2019	2019	NUM
admet-733	122	20	)	)	PUNCT
admet-733	122	21	222	222	NUM
admet-733	122	22	-	-	SYM
admet-733	122	23	241	241	NUM
admet-733	122	24	230	230	NUM
admet-733	122	25	exposed	expose	VERB
admet-733	122	26	,	,	PUNCT
admet-733	122	27	there	there	PRON
admet-733	122	28	is	be	VERB
admet-733	122	29	increased	increase	VERB
admet-733	122	30	dye	dye	NOUN
admet-733	122	31	binding	bind	VERB
admet-733	122	32	and	and	CCONJ
admet-733	122	33	the	the	DET
admet-733	122	34	fluorescence	fluorescence	NOUN
admet-733	122	35	intensity	intensity	NOUN
admet-733	122	36	increases	increase	NOUN
admet-733	122	37	.	.	PUNCT
admet-733	123	1	compounds	compound	NOUN
admet-733	123	2	that	that	PRON
admet-733	123	3	increase	increase	VERB
admet-733	123	4	the	the	DET
admet-733	123	5	thermal	thermal	ADJ
admet-733	123	6	stability	stability	NOUN
admet-733	123	7	of	of	ADP
admet-733	123	8	the	the	DET
admet-733	123	9	protein	protein	NOUN
admet-733	123	10	may	may	AUX
admet-733	123	11	be	be	AUX
admet-733	123	12	identified	identify	VERB
admet-733	123	13	as	as	ADP
admet-733	123	14	those	those	PRON
admet-733	123	15	giving	give	VERB
admet-733	123	16	an	an	DET
admet-733	123	17	increased	increase	VERB
admet-733	123	18	tm	tm	NOUN
admet-733	123	19	,	,	PUNCT
admet-733	123	20	resulting	result	VERB
admet-733	123	21	from	from	ADP
admet-733	123	22	a	a	DET
admet-733	123	23	shift	shift	NOUN
admet-733	123	24	in	in	ADP
admet-733	123	25	the	the	DET
admet-733	123	26	unfolding	unfold	VERB
admet-733	123	27	curve	curve	NOUN
admet-733	123	28	to	to	ADP
admet-733	123	29	higher	high	ADJ
admet-733	123	30	temperatures	temperature	NOUN
admet-733	123	31	,	,	PUNCT
admet-733	123	32	figure	figure	NOUN
admet-733	123	33	3(a	3(a	NUM
admet-733	123	34	)	)	PUNCT
admet-733	123	35	.	.	PUNCT
admet-733	124	1	0	0	NUM
admet-733	125	1	10	10	NUM
admet-733	125	2	20	20	NUM
admet-733	125	3	30	30	NUM
admet-733	125	4	40	40	NUM
admet-733	125	5	50	50	NUM
admet-733	125	6	60	60	NUM
admet-733	125	7	70	70	NUM
admet-733	125	8	0	0	NUM
admet-733	125	9	1000	1000	NUM
admet-733	125	10	2000	2000	NUM
admet-733	125	11	3000	3000	NUM
admet-733	125	12	4000	4000	NUM
admet-733	125	13	5000	5000	NUM
admet-733	125	14	temperature	temperature	NOUN
admet-733	125	15	°	°	NOUN
admet-733	125	16	c	c	NOUN
admet-733	125	17	r	r	NOUN
admet-733	125	18	f	f	NOUN
admet-733	125	19	u	u	NOUN
admet-733	125	20	0	0	NUM
admet-733	125	21	20	20	NUM
admet-733	125	22	40	40	NUM
admet-733	125	23	60	60	NUM
admet-733	125	24	80	80	NUM
admet-733	125	25	-100	-100	PROPN
admet-733	125	26	0	0	NUM
admet-733	125	27	100	100	NUM
admet-733	125	28	200	200	NUM
admet-733	125	29	300	300	NUM
admet-733	125	30	400	400	NUM
admet-733	125	31	temperature	temperature	NOUN
admet-733	125	32	°	°	ADP
admet-733	125	33	c	c	NOUN
admet-733	125	34			NUM
admet-733	125	35	r	r	NOUN
admet-733	125	36	f	f	PROPN
admet-733	125	37	u	u	PROPN
admet-733	125	38	/	/	PROPN
admet-733	125	39	t	t	PROPN
admet-733	125	40	figure	figure	NOUN
admet-733	125	41	3	3	NUM
admet-733	125	42	.	.	PUNCT
admet-733	126	1	(	(	PUNCT
admet-733	126	2	a	a	X
admet-733	126	3	)	)	PUNCT
admet-733	126	4	typical	typical	ADJ
admet-733	126	5	unfolding	unfold	VERB
admet-733	126	6	curve	curve	NOUN
admet-733	126	7	in	in	ADP
admet-733	126	8	a	a	DET
admet-733	126	9	tsa	tsa	NOUN
admet-733	126	10	.	.	PUNCT
admet-733	127	1	squares	square	NOUN
admet-733	127	2	/	/	SYM
admet-733	127	3	solid	solid	ADJ
admet-733	127	4	line	line	NOUN
admet-733	127	5	show	show	VERB
admet-733	127	6	the	the	DET
admet-733	127	7	protein	protein	NOUN
admet-733	127	8	unfolding	unfold	VERB
admet-733	127	9	in	in	ADP
admet-733	127	10	the	the	DET
admet-733	127	11	absence	absence	NOUN
admet-733	127	12	of	of	ADP
admet-733	127	13	ligand	ligand	NOUN
admet-733	127	14	.	.	PUNCT
admet-733	128	1	triangles	triangle	NOUN
admet-733	128	2	/	/	PUNCT
admet-733	128	3	dotted	dot	VERB
admet-733	128	4	line	line	NOUN
admet-733	128	5	show	show	NOUN
admet-733	128	6	unfolding	unfolding	NOUN
admet-733	128	7	in	in	ADP
admet-733	128	8	the	the	DET
admet-733	128	9	presence	presence	NOUN
admet-733	128	10	of	of	ADP
admet-733	128	11	a	a	DET
admet-733	128	12	compound	compound	NOUN
admet-733	128	13	that	that	PRON
admet-733	128	14	stabilises	stabilise	VERB
admet-733	128	15	by	by	ADP
admet-733	128	16	5	5	NUM
admet-733	128	17	°	°	NOUN
admet-733	128	18	c	c	NOUN
admet-733	128	19	.	.	PUNCT
admet-733	129	1	the	the	DET
admet-733	129	2	red	red	ADJ
admet-733	129	3	arrow	arrow	NOUN
admet-733	129	4	indicates	indicate	VERB
admet-733	129	5	the	the	DET
admet-733	129	6	shift	shift	NOUN
admet-733	129	7	in	in	ADP
admet-733	129	8	tm	tm	PROPN
admet-733	129	9	caused	cause	VERB
admet-733	129	10	by	by	ADP
admet-733	129	11	the	the	DET
admet-733	129	12	addition	addition	NOUN
admet-733	129	13	of	of	ADP
admet-733	129	14	compound	compound	NOUN
admet-733	129	15	;	;	PUNCT
admet-733	129	16	(	(	PUNCT
admet-733	129	17	b	b	X
admet-733	129	18	)	)	PUNCT
admet-733	129	19	first	first	ADJ
admet-733	129	20	derivative	derivative	NOUN
admet-733	129	21	of	of	ADP
admet-733	129	22	the	the	DET
admet-733	129	23	data	datum	NOUN
admet-733	129	24	in	in	ADP
admet-733	129	25	(	(	PUNCT
admet-733	129	26	a	a	NOUN
admet-733	129	27	)	)	PUNCT
admet-733	129	28	.	.	PUNCT
admet-733	130	1	the	the	DET
admet-733	130	2	advantages	advantage	NOUN
admet-733	130	3	of	of	ADP
admet-733	130	4	tsa	tsa	NOUN
admet-733	130	5	as	as	ADP
admet-733	130	6	a	a	DET
admet-733	130	7	primary	primary	ADJ
admet-733	130	8	screening	screening	NOUN
admet-733	130	9	method	method	NOUN
admet-733	130	10	include	include	VERB
admet-733	130	11	the	the	DET
admet-733	130	12	simplicity	simplicity	NOUN
admet-733	130	13	of	of	ADP
admet-733	130	14	the	the	DET
admet-733	130	15	approach	approach	NOUN
admet-733	130	16	,	,	PUNCT
admet-733	130	17	the	the	DET
admet-733	130	18	cost	cost	NOUN
admet-733	130	19	effectiveness	effectiveness	NOUN
admet-733	130	20	and	and	CCONJ
admet-733	130	21	the	the	DET
admet-733	130	22	potential	potential	NOUN
admet-733	130	23	to	to	PART
admet-733	130	24	access	access	VERB
admet-733	130	25	a	a	DET
admet-733	130	26	wide	wide	ADJ
admet-733	130	27	range	range	NOUN
admet-733	130	28	of	of	ADP
admet-733	130	29	binding	bind	VERB
admet-733	130	30	affinities	affinity	NOUN
admet-733	130	31	.	.	PUNCT
admet-733	131	1	the	the	DET
admet-733	131	2	method	method	NOUN
admet-733	131	3	requires	require	VERB
admet-733	131	4	little	little	ADJ
admet-733	131	5	assay	assay	NOUN
admet-733	131	6	development	development	NOUN
admet-733	131	7	,	,	PUNCT
admet-733	131	8	which	which	PRON
admet-733	131	9	is	be	AUX
admet-733	131	10	in	in	ADP
admet-733	131	11	effect	effect	NOUN
admet-733	131	12	limited	limit	VERB
admet-733	131	13	to	to	ADP
admet-733	131	14	adjusting	adjust	VERB
admet-733	131	15	[	[	X
admet-733	131	16	protein	protein	NOUN
admet-733	131	17	]	]	PUNCT
admet-733	131	18	and	and	CCONJ
admet-733	131	19	[	[	X
admet-733	131	20	dye	dye	NOUN
admet-733	131	21	]	]	PUNCT
admet-733	131	22	to	to	PART
admet-733	131	23	give	give	VERB
admet-733	131	24	a	a	DET
admet-733	131	25	suitable	suitable	ADJ
admet-733	131	26	signal	signal	NOUN
admet-733	131	27	.	.	PUNCT
admet-733	132	1	the	the	DET
admet-733	132	2	reagent	reagent	ADJ
admet-733	132	3	requirements	requirement	NOUN
admet-733	132	4	are	be	AUX
admet-733	132	5	protein	protein	NOUN
admet-733	132	6	and	and	CCONJ
admet-733	132	7	dye	dye	VERB
admet-733	132	8	only	only	ADV
admet-733	132	9	,	,	PUNCT
admet-733	132	10	meaning	mean	VERB
admet-733	132	11	that	that	SCONJ
admet-733	132	12	the	the	DET
admet-733	132	13	costs	cost	NOUN
admet-733	132	14	associated	associate	VERB
admet-733	132	15	with	with	ADP
admet-733	132	16	expensive	expensive	ADJ
admet-733	132	17	biochemical	biochemical	ADJ
admet-733	132	18	reagents	reagent	NOUN
admet-733	132	19	are	be	AUX
admet-733	132	20	avoided	avoid	VERB
admet-733	132	21	.	.	PUNCT
admet-733	133	1	the	the	DET
admet-733	133	2	method	method	NOUN
admet-733	133	3	does	do	AUX
admet-733	133	4	not	not	PART
admet-733	133	5	require	require	VERB
admet-733	133	6	specialised	specialised	ADJ
admet-733	133	7	instrumentation	instrumentation	NOUN
admet-733	133	8	and	and	CCONJ
admet-733	133	9	is	be	AUX
admet-733	133	10	carried	carry	VERB
admet-733	133	11	out	out	ADP
admet-733	133	12	using	use	VERB
admet-733	133	13	standard	standard	ADJ
admet-733	133	14	thermocyclers	thermocycler	NOUN
admet-733	133	15	often	often	ADV
admet-733	133	16	used	use	VERB
admet-733	133	17	for	for	ADP
admet-733	133	18	real	real	ADJ
admet-733	133	19	-	-	PUNCT
admet-733	133	20	time	time	NOUN
admet-733	133	21	polymerase	polymerase	NOUN
admet-733	133	22	chain	chain	NOUN
admet-733	133	23	reactions	reaction	NOUN
admet-733	133	24	(	(	PUNCT
admet-733	133	25	rt	rt	NOUN
admet-733	133	26	-	-	PUNCT
admet-733	133	27	pcr	pcr	NOUN
admet-733	133	28	)	)	PUNCT
admet-733	133	29	.	.	PUNCT
admet-733	134	1	protein	protein	NOUN
admet-733	134	2	quantities	quantity	NOUN
admet-733	134	3	can	can	AUX
admet-733	134	4	potentially	potentially	ADV
admet-733	134	5	limit	limit	VERB
admet-733	134	6	the	the	DET
admet-733	134	7	method	method	NOUN
admet-733	134	8	,	,	PUNCT
admet-733	134	9	since	since	SCONJ
admet-733	134	10	screening	screen	VERB
admet-733	134	11	500,000	500,000	NUM
admet-733	134	12	single	single	ADJ
admet-733	134	13	wells	well	NOUN
admet-733	134	14	can	can	AUX
admet-733	134	15	require	require	VERB
admet-733	134	16	around	around	ADV
admet-733	134	17	0.5	0.5	NUM
admet-733	134	18	g	g	NOUN
admet-733	134	19	of	of	ADP
admet-733	134	20	a	a	DET
admet-733	134	21	40	40	NUM
admet-733	134	22	kda	kda	NOUN
admet-733	134	23	target	target	NOUN
admet-733	134	24	protein	protein	NOUN
admet-733	134	25	.	.	PUNCT
admet-733	135	1	whilst	whilst	SCONJ
admet-733	135	2	there	there	PRON
admet-733	135	3	is	be	VERB
admet-733	135	4	no	no	DET
admet-733	135	5	direct	direct	ADJ
admet-733	135	6	correlation	correlation	NOUN
admet-733	135	7	between	between	ADP
admet-733	135	8	tm	tm	PROPN
admet-733	135	9	and	and	CCONJ
admet-733	135	10	kd	kd	X
admet-733	136	1	[	[	X
admet-733	136	2	24	24	NUM
admet-733	136	3	]	]	PUNCT
admet-733	136	4	,	,	PUNCT
admet-733	136	5	due	due	ADP
admet-733	136	6	to	to	ADP
admet-733	136	7	differences	difference	NOUN
admet-733	136	8	in	in	ADP
admet-733	136	9	enthalpic	enthalpic	ADJ
admet-733	136	10	and	and	CCONJ
admet-733	136	11	entropic	entropic	ADJ
admet-733	136	12	contributions	contribution	NOUN
admet-733	136	13	to	to	ADP
admet-733	136	14	binding	bind	VERB
admet-733	136	15	affinity	affinity	NOUN
admet-733	136	16	having	have	VERB
admet-733	136	17	a	a	DET
admet-733	136	18	differing	differ	VERB
admet-733	136	19	effect	effect	NOUN
admet-733	136	20	on	on	ADP
admet-733	136	21	tm	tm	PROPN
admet-733	136	22	,	,	PUNCT
admet-733	136	23	it	it	PRON
admet-733	136	24	is	be	AUX
admet-733	136	25	possible	possible	ADJ
admet-733	136	26	to	to	PART
admet-733	136	27	observe	observe	VERB
admet-733	136	28	stabilisation	stabilisation	NOUN
admet-733	136	29	conferred	confer	VERB
admet-733	136	30	by	by	ADP
admet-733	136	31	ligands	ligand	NOUN
admet-733	136	32	covering	cover	VERB
admet-733	136	33	a	a	DET
admet-733	136	34	wide	wide	ADJ
admet-733	136	35	range	range	NOUN
admet-733	136	36	of	of	ADP
admet-733	136	37	affinities	affinity	NOUN
admet-733	136	38	from	from	ADP
admet-733	136	39	mm	mm	PROPN
admet-733	136	40	to	to	ADP
admet-733	136	41	very	very	ADV
admet-733	136	42	tight	tight	ADV
admet-733	136	43	-	-	PUNCT
admet-733	136	44	binding	bind	VERB
admet-733	136	45	.	.	PUNCT
admet-733	137	1	analysis	analysis	NOUN
admet-733	137	2	of	of	ADP
admet-733	137	3	tsa	tsa	NOUN
admet-733	137	4	data	datum	NOUN
admet-733	137	5	typically	typically	ADV
admet-733	137	6	involves	involve	VERB
admet-733	137	7	determining	determine	VERB
admet-733	137	8	the	the	DET
admet-733	137	9	tm	tm	NOUN
admet-733	137	10	for	for	ADP
admet-733	137	11	each	each	DET
admet-733	137	12	curve	curve	NOUN
admet-733	137	13	,	,	PUNCT
admet-733	137	14	which	which	PRON
admet-733	137	15	can	can	AUX
admet-733	137	16	be	be	AUX
admet-733	137	17	achieved	achieve	VERB
admet-733	137	18	by	by	ADP
admet-733	137	19	fitting	fit	VERB
admet-733	137	20	an	an	DET
admet-733	137	21	appropriate	appropriate	ADJ
admet-733	137	22	equation	equation	NOUN
admet-733	137	23	to	to	ADP
admet-733	137	24	the	the	DET
admet-733	137	25	data	datum	NOUN
admet-733	137	26	,	,	PUNCT
admet-733	137	27	or	or	CCONJ
admet-733	137	28	for	for	ADP
admet-733	137	29	simple	simple	ADJ
admet-733	137	30	2	2	NUM
admet-733	137	31	state	state	NOUN
admet-733	137	32	transitions	transition	NOUN
admet-733	137	33	,	,	PUNCT
admet-733	137	34	simply	simply	ADV
admet-733	137	35	by	by	ADP
admet-733	137	36	taking	take	VERB
admet-733	137	37	the	the	DET
admet-733	137	38	first	first	ADJ
admet-733	137	39	derivative	derivative	NOUN
admet-733	137	40	of	of	ADP
admet-733	137	41	the	the	DET
admet-733	137	42	fluorescence	fluorescence	NOUN
admet-733	137	43	versus	versus	ADP
admet-733	137	44	temperature	temperature	NOUN
admet-733	137	45	data	datum	NOUN
admet-733	137	46	,	,	PUNCT
admet-733	137	47	figure	figure	VERB
admet-733	137	48	3	3	NUM
admet-733	137	49	(	(	PUNCT
admet-733	137	50	b	b	NOUN
admet-733	137	51	)	)	PUNCT
admet-733	137	52	.	.	PUNCT
admet-733	138	1	for	for	ADP
admet-733	138	2	high	high	ADJ
admet-733	138	3	-	-	PUNCT
admet-733	138	4	throughput	throughput	NOUN
admet-733	138	5	analysis	analysis	NOUN
admet-733	138	6	genedata	genedata	ADJ
admet-733	138	7	screener	screener	NOUN
admet-733	138	8	®	®	NOUN
admet-733	138	9	(	(	PUNCT
admet-733	138	10	genedata	genedata	PROPN
admet-733	138	11	,	,	PUNCT
admet-733	138	12	basel	basel	PROPN
admet-733	138	13	,	,	PUNCT
admet-733	138	14	switzerland	switzerland	PROPN
admet-733	138	15	)	)	PUNCT
admet-733	138	16	includes	include	VERB
admet-733	138	17	a	a	DET
admet-733	138	18	module	module	NOUN
admet-733	138	19	that	that	PRON
admet-733	138	20	can	can	AUX
admet-733	138	21	robustly	robustly	ADV
admet-733	138	22	and	and	CCONJ
admet-733	138	23	efficiently	efficiently	ADV
admet-733	138	24	analyse	analyse	VERB
admet-733	138	25	the	the	DET
admet-733	138	26	many	many	ADJ
admet-733	138	27	temperature	temperature	NOUN
admet-733	138	28	curves	curve	NOUN
admet-733	138	29	created	create	VERB
admet-733	138	30	,	,	PUNCT
admet-733	138	31	which	which	PRON
admet-733	138	32	significantly	significantly	ADV
admet-733	138	33	reduces	reduce	VERB
admet-733	138	34	the	the	DET
admet-733	138	35	analysis	analysis	NOUN
admet-733	138	36	time	time	NOUN
admet-733	138	37	.	.	PUNCT
admet-733	139	1	fragment	fragment	NOUN
admet-733	139	2	-	-	PUNCT
admet-733	139	3	based	base	VERB
admet-733	139	4	screening	screen	VERB
admet-733	139	5	fragment	fragment	NOUN
admet-733	139	6	-	-	PUNCT
admet-733	139	7	based	base	VERB
admet-733	139	8	drug	drug	NOUN
admet-733	139	9	discovery	discovery	NOUN
admet-733	139	10	(	(	PUNCT
admet-733	139	11	fbdd	fbdd	PROPN
admet-733	139	12	)	)	PUNCT
admet-733	139	13	is	be	AUX
admet-733	139	14	now	now	ADV
admet-733	139	15	a	a	DET
admet-733	139	16	well	well	ADV
admet-733	139	17	-	-	PUNCT
admet-733	139	18	established	establish	VERB
admet-733	139	19	approach	approach	NOUN
admet-733	139	20	with	with	ADP
admet-733	139	21	fbdd	fbdd	NOUN
admet-733	139	22	having	having	AUX
admet-733	139	23	delivered	deliver	VERB
admet-733	139	24	2	2	NUM
admet-733	139	25	marketed	market	VERB
admet-733	139	26	medicines	medicine	NOUN
admet-733	139	27	(	(	PUNCT
admet-733	139	28	vemurafenib	vemurafenib	NOUN
admet-733	139	29	and	and	CCONJ
admet-733	139	30	venetoclax	venetoclax	NOUN
admet-733	139	31	)	)	PUNCT
admet-733	139	32	and	and	CCONJ
admet-733	139	33	around	around	ADV
admet-733	139	34	35	35	NUM
admet-733	139	35	compounds	compound	NOUN
admet-733	139	36	currently	currently	ADV
admet-733	139	37	in	in	ADP
admet-733	139	38	clinical	clinical	ADJ
admet-733	139	39	trials	trial	NOUN
admet-733	139	40	[	[	X
admet-733	139	41	25	25	NUM
admet-733	139	42	]	]	PUNCT
admet-733	139	43	.	.	PUNCT
admet-733	140	1	identifying	identify	VERB
admet-733	140	2	fragment	fragment	NOUN
admet-733	140	3	hits	hit	NOUN
admet-733	140	4	is	be	AUX
admet-733	140	5	a	a	DET
admet-733	140	6	challenge	challenge	NOUN
admet-733	140	7	in	in	ADP
admet-733	140	8	traditional	traditional	ADJ
admet-733	140	9	biochemical	biochemical	ADJ
admet-733	140	10	assays	assay	NOUN
admet-733	140	11	,	,	PUNCT
admet-733	140	12	since	since	SCONJ
admet-733	140	13	they	they	PRON
admet-733	140	14	are	be	AUX
admet-733	140	15	likely	likely	ADJ
admet-733	140	16	to	to	PART
admet-733	140	17	bind	bind	VERB
admet-733	140	18	weakly	weakly	ADV
admet-733	140	19	to	to	ADP
admet-733	140	20	the	the	DET
admet-733	140	21	target	target	NOUN
admet-733	140	22	protein	protein	NOUN
admet-733	140	23	,	,	PUNCT
admet-733	140	24	and	and	CCONJ
admet-733	140	25	the	the	DET
admet-733	140	26	apparent	apparent	ADJ
admet-733	140	27	affinity	affinity	NOUN
admet-733	140	28	may	may	AUX
admet-733	140	29	be	be	AUX
admet-733	140	30	weaker	weak	ADJ
admet-733	140	31	still	still	ADV
admet-733	140	32	,	,	PUNCT
admet-733	140	33	due	due	ADP
admet-733	140	34	to	to	ADP
admet-733	140	35	competition	competition	NOUN
admet-733	140	36	with	with	ADP
admet-733	140	37	substrates	substrate	NOUN
admet-733	140	38	.	.	PUNCT
admet-733	141	1	biophysical	biophysical	ADJ
admet-733	141	2	methods	method	NOUN
admet-733	141	3	are	be	AUX
admet-733	141	4	well	well	ADV
admet-733	141	5	suited	suited	ADJ
admet-733	141	6	to	to	ADP
admet-733	141	7	fragment	fragment	NOUN
admet-733	141	8	-	-	PUNCT
admet-733	141	9	based	base	VERB
admet-733	141	10	screening	screening	NOUN
admet-733	141	11	[	[	X
admet-733	141	12	25	25	NUM
admet-733	141	13	]	]	PUNCT
admet-733	141	14	,	,	PUNCT
admet-733	141	15	as	as	SCONJ
admet-733	141	16	they	they	PRON
admet-733	141	17	are	be	AUX
admet-733	141	18	sufficiently	sufficiently	ADV
admet-733	141	19	sensitive	sensitive	ADJ
admet-733	141	20	to	to	PART
admet-733	141	21	detect	detect	VERB
admet-733	141	22	weak	weak	ADJ
admet-733	141	23	interactions	interaction	NOUN
admet-733	141	24	,	,	PUNCT
admet-733	141	25	and	and	CCONJ
admet-733	141	26	reliable	reliable	ADJ
admet-733	141	27	enough	enough	ADV
admet-733	141	28	to	to	PART
admet-733	141	29	avoid	avoid	VERB
admet-733	141	30	false	false	ADJ
admet-733	141	31	hits	hit	NOUN
admet-733	141	32	.	.	PUNCT
admet-733	142	1	historically	historically	ADV
admet-733	142	2	,	,	PUNCT
admet-733	142	3	techniques	technique	NOUN
admet-733	142	4	including	include	VERB
admet-733	142	5	nmr	nmr	NOUN
admet-733	142	6	,	,	PUNCT
admet-733	142	7	spr	spr	ADJ
admet-733	142	8	and	and	CCONJ
admet-733	142	9	x	x	ADJ
admet-733	142	10	-	-	NOUN
admet-733	142	11	ray	ray	NOUN
admet-733	142	12	crystallography	crystallography	NOUN
admet-733	142	13	were	be	AUX
admet-733	142	14	applied	apply	VERB
admet-733	142	15	to	to	ADP
admet-733	142	16	fragment	fragment	ADJ
admet-733	142	17	screening	screening	NOUN
admet-733	142	18	,	,	PUNCT
admet-733	142	19	but	but	CCONJ
admet-733	142	20	more	more	ADV
admet-733	142	21	recently	recently	ADV
admet-733	142	22	methods	method	NOUN
admet-733	142	23	such	such	ADJ
admet-733	142	24	as	as	ADP
admet-733	142	25	microscale	microscale	ADJ
admet-733	142	26	thermophoresis	thermophoresis	NOUN
admet-733	142	27	(	(	PUNCT
admet-733	142	28	mst	mst	PROPN
admet-733	142	29	)	)	PUNCT
admet-733	143	1	[	[	X
admet-733	143	2	26	26	NUM
admet-733	143	3	]	]	PUNCT
admet-733	143	4	and	and	CCONJ
admet-733	143	5	tsa	tsa	NOUN
admet-733	143	6	have	have	AUX
admet-733	143	7	also	also	ADV
admet-733	143	8	been	be	AUX
admet-733	143	9	used	use	VERB
admet-733	143	10	.	.	PUNCT
admet-733	144	1	compared	compare	VERB
admet-733	144	2	to	to	ADP
admet-733	144	3	traditional	traditional	ADJ
admet-733	144	4	hts	ht	NOUN
admet-733	144	5	,	,	PUNCT
admet-733	144	6	the	the	DET
admet-733	144	7	throughput	throughput	NOUN
admet-733	144	8	of	of	ADP
admet-733	144	9	fragment	fragment	ADJ
admet-733	144	10	screening	screening	NOUN
admet-733	144	11	is	be	AUX
admet-733	144	12	generally	generally	ADV
admet-733	144	13	lower	low	ADJ
admet-733	144	14	,	,	PUNCT
admet-733	144	15	and	and	CCONJ
admet-733	144	16	the	the	DET
admet-733	144	17	(	(	PUNCT
admet-733	144	18	a	a	NOUN
admet-733	144	19	)	)	PUNCT
admet-733	144	20	(	(	PUNCT
admet-733	144	21	b	b	X
admet-733	144	22	)	)	PUNCT
admet-733	144	23	admet	admet	PROPN
admet-733	144	24	&	&	CCONJ
admet-733	144	25	dmpk	dmpk	PROPN
admet-733	144	26	7(4	7(4	NUM
admet-733	144	27	)	)	PUNCT
admet-733	144	28	(	(	PUNCT
admet-733	144	29	2019	2019	NUM
admet-733	144	30	)	)	PUNCT
admet-733	144	31	222	222	NUM
admet-733	144	32	-	-	PUNCT
admet-733	144	33	241	241	NUM
admet-733	144	34	biophysical	biophysical	ADJ
admet-733	144	35	methods	method	NOUN
admet-733	144	36	in	in	ADP
admet-733	144	37	early	early	ADJ
admet-733	144	38	drug	drug	NOUN
admet-733	144	39	discovery	discovery	NOUN
admet-733	144	40	doi	doi	PROPN
admet-733	144	41	:	:	PUNCT
admet-733	144	42	10.5599	10.5599	NUM
admet-733	144	43	/	/	SYM
admet-733	144	44	admet.733	admet.733	ADJ
admet-733	144	45	231	231	NUM
admet-733	144	46	biophysical	biophysical	ADJ
admet-733	144	47	methods	method	NOUN
admet-733	144	48	employed	employ	VERB
admet-733	144	49	often	often	ADV
admet-733	144	50	require	require	VERB
admet-733	144	51	larger	large	ADJ
admet-733	144	52	quantities	quantity	NOUN
admet-733	144	53	of	of	ADP
admet-733	144	54	protein	protein	NOUN
admet-733	144	55	.	.	PUNCT
admet-733	145	1	fortunately	fortunately	ADV
admet-733	145	2	,	,	PUNCT
admet-733	145	3	this	this	DET
admet-733	145	4	issue	issue	NOUN
admet-733	145	5	is	be	AUX
admet-733	145	6	overcome	overcome	VERB
admet-733	145	7	by	by	ADP
admet-733	145	8	the	the	DET
admet-733	145	9	ability	ability	NOUN
admet-733	145	10	to	to	PART
admet-733	145	11	screen	screen	VERB
admet-733	145	12	fewer	few	ADJ
admet-733	145	13	molecules	molecule	NOUN
admet-733	145	14	,	,	PUNCT
admet-733	145	15	but	but	CCONJ
admet-733	145	16	to	to	PART
admet-733	145	17	cover	cover	VERB
admet-733	145	18	a	a	DET
admet-733	145	19	much	much	ADV
admet-733	145	20	larger	large	ADJ
admet-733	145	21	proportion	proportion	NOUN
admet-733	145	22	of	of	ADP
admet-733	145	23	chemical	chemical	ADJ
admet-733	145	24	space	space	NOUN
admet-733	145	25	using	use	VERB
admet-733	145	26	fragment	fragment	NOUN
admet-733	145	27	screening	screening	NOUN
admet-733	145	28	libraries	library	NOUN
admet-733	145	29	.	.	PUNCT
admet-733	146	1	for	for	ADP
admet-733	146	2	example	example	NOUN
admet-733	146	3	,	,	PUNCT
admet-733	146	4	screening	screen	VERB
admet-733	146	5	1	1	NUM
admet-733	146	6	million	million	NUM
admet-733	146	7	compounds	compound	NOUN
admet-733	146	8	out	out	ADP
admet-733	146	9	of	of	ADP
admet-733	146	10	the	the	DET
admet-733	146	11	estimated	estimate	VERB
admet-733	146	12	1030	1030	NUM
admet-733	146	13	compounds	compound	NOUN
admet-733	146	14	that	that	PRON
admet-733	146	15	could	could	AUX
admet-733	146	16	potentially	potentially	ADV
admet-733	146	17	be	be	AUX
admet-733	146	18	synthesised	synthesise	VERB
admet-733	146	19	with	with	ADP
admet-733	146	20	36	36	NUM
admet-733	146	21	heavy	heavy	ADJ
admet-733	146	22	atoms	atom	NOUN
admet-733	146	23	(	(	PUNCT
admet-733	146	24	around	around	ADP
admet-733	146	25	500	500	NUM
admet-733	146	26	da	da	NOUN
admet-733	146	27	)	)	PUNCT
admet-733	146	28	is	be	AUX
admet-733	146	29	1019	1019	NUM
admet-733	146	30	-	-	NUM
admet-733	146	31	fold	fold	VERB
admet-733	146	32	less	less	ADV
admet-733	146	33	efficient	efficient	ADJ
admet-733	146	34	than	than	ADP
admet-733	146	35	screening	screen	VERB
admet-733	146	36	1000	1000	NUM
admet-733	146	37	compounds	compound	NOUN
admet-733	146	38	from	from	ADP
admet-733	146	39	the	the	DET
admet-733	146	40	108	108	NUM
admet-733	146	41	potential	potential	ADJ
admet-733	146	42	compounds	compound	NOUN
admet-733	146	43	with	with	ADP
admet-733	146	44	12	12	NUM
admet-733	146	45	heavy	heavy	ADJ
admet-733	146	46	atoms	atom	NOUN
admet-733	146	47	(	(	PUNCT
admet-733	146	48	around	around	ADP
admet-733	146	49	160	160	NUM
admet-733	146	50	da	da	NOUN
admet-733	146	51	)	)	PUNCT
admet-733	146	52	.	.	PUNCT
admet-733	147	1	another	another	DET
admet-733	147	2	way	way	NOUN
admet-733	147	3	of	of	ADP
admet-733	147	4	considering	consider	VERB
admet-733	147	5	this	this	PRON
admet-733	147	6	is	be	AUX
admet-733	147	7	to	to	PART
admet-733	147	8	reframe	reframe	VERB
admet-733	147	9	the	the	DET
admet-733	147	10	coverage	coverage	NOUN
admet-733	147	11	of	of	ADP
admet-733	147	12	chemical	chemical	ADJ
admet-733	147	13	space	space	NOUN
admet-733	147	14	by	by	ADP
admet-733	147	15	considering	consider	VERB
admet-733	147	16	how	how	SCONJ
admet-733	147	17	many	many	ADJ
admet-733	147	18	compounds	compound	NOUN
admet-733	147	19	need	need	VERB
admet-733	147	20	to	to	PART
admet-733	147	21	be	be	AUX
admet-733	147	22	screened	screen	VERB
admet-733	147	23	in	in	ADP
admet-733	147	24	order	order	NOUN
admet-733	147	25	to	to	PART
admet-733	147	26	obtain	obtain	VERB
admet-733	147	27	a	a	DET
admet-733	147	28	sufficient	sufficient	ADJ
admet-733	147	29	number	number	NOUN
admet-733	147	30	of	of	ADP
admet-733	147	31	hits	hit	NOUN
admet-733	147	32	against	against	ADP
admet-733	147	33	the	the	DET
admet-733	147	34	target	target	NOUN
admet-733	147	35	of	of	ADP
admet-733	147	36	interest	interest	NOUN
admet-733	147	37	.	.	PUNCT
admet-733	148	1	hann	hann	PROPN
admet-733	148	2	,	,	PUNCT
admet-733	148	3	et	et	PROPN
admet-733	148	4	al	al	PROPN
admet-733	149	1	[	[	X
admet-733	149	2	27	27	NUM
admet-733	149	3	]	]	PUNCT
admet-733	149	4	found	find	VERB
admet-733	149	5	that	that	SCONJ
admet-733	149	6	hit	hit	NOUN
admet-733	149	7	rates	rate	NOUN
admet-733	149	8	decreased	decrease	VERB
admet-733	149	9	as	as	SCONJ
admet-733	149	10	the	the	DET
admet-733	149	11	complexity	complexity	NOUN
admet-733	149	12	of	of	ADP
admet-733	149	13	ligands	ligand	NOUN
admet-733	149	14	increased	increase	VERB
admet-733	149	15	.	.	PUNCT
admet-733	150	1	of	of	ADP
admet-733	150	2	course	course	NOUN
admet-733	150	3	,	,	PUNCT
admet-733	150	4	smaller	small	ADJ
admet-733	150	5	ligands	ligand	NOUN
admet-733	150	6	will	will	AUX
admet-733	150	7	generally	generally	ADV
admet-733	150	8	bind	bind	VERB
admet-733	150	9	less	less	ADV
admet-733	150	10	tightly	tightly	ADV
admet-733	150	11	and	and	CCONJ
admet-733	150	12	so	so	ADV
admet-733	150	13	the	the	DET
admet-733	150	14	apparent	apparent	ADJ
admet-733	150	15	hit	hit	VERB
admet-733	150	16	rate	rate	NOUN
admet-733	150	17	depends	depend	VERB
admet-733	150	18	upon	upon	SCONJ
admet-733	150	19	the	the	DET
admet-733	150	20	sensitivity	sensitivity	NOUN
admet-733	150	21	of	of	ADP
admet-733	150	22	the	the	DET
admet-733	150	23	detection	detection	NOUN
admet-733	150	24	method	method	NOUN
admet-733	150	25	.	.	PUNCT
admet-733	151	1	thus	thus	ADV
admet-733	151	2	,	,	PUNCT
admet-733	151	3	the	the	DET
admet-733	151	4	probability	probability	NOUN
admet-733	151	5	of	of	ADP
admet-733	151	6	detecting	detect	VERB
admet-733	151	7	binding	bind	VERB
admet-733	151	8	for	for	ADP
admet-733	151	9	ligands	ligand	NOUN
admet-733	151	10	of	of	ADP
admet-733	151	11	different	different	ADJ
admet-733	151	12	sizes	size	NOUN
admet-733	151	13	is	be	AUX
admet-733	151	14	expected	expect	VERB
admet-733	151	15	to	to	PART
admet-733	151	16	be	be	AUX
admet-733	151	17	low	low	ADJ
admet-733	151	18	for	for	ADP
admet-733	151	19	very	very	ADV
admet-733	151	20	small	small	ADJ
admet-733	151	21	ligands	ligand	NOUN
admet-733	151	22	(	(	PUNCT
admet-733	151	23	due	due	ADP
admet-733	151	24	to	to	ADP
admet-733	151	25	detection	detection	NOUN
admet-733	151	26	sensitivity	sensitivity	NOUN
admet-733	151	27	)	)	PUNCT
admet-733	151	28	high	high	ADJ
admet-733	151	29	for	for	ADP
admet-733	151	30	small	small	ADJ
admet-733	151	31	ligands	ligand	NOUN
admet-733	151	32	and	and	CCONJ
admet-733	151	33	decreases	decrease	NOUN
admet-733	151	34	with	with	ADP
admet-733	151	35	size	size	NOUN
admet-733	151	36	for	for	ADP
admet-733	151	37	larger	large	ADJ
admet-733	151	38	ligands	ligand	NOUN
admet-733	151	39	(	(	PUNCT
admet-733	151	40	due	due	ADP
admet-733	151	41	to	to	ADP
admet-733	151	42	the	the	DET
admet-733	151	43	increasing	increase	VERB
admet-733	151	44	probability	probability	NOUN
admet-733	151	45	of	of	ADP
admet-733	151	46	steric	steric	ADJ
admet-733	151	47	clashes	clash	NOUN
admet-733	151	48	between	between	ADP
admet-733	151	49	the	the	DET
admet-733	151	50	ligand	ligand	NOUN
admet-733	151	51	and	and	CCONJ
admet-733	151	52	protein	protein	NOUN
admet-733	151	53	)	)	PUNCT
admet-733	151	54	.	.	PUNCT
admet-733	152	1	this	this	PRON
admet-733	152	2	suggests	suggest	VERB
admet-733	152	3	that	that	SCONJ
admet-733	152	4	focusing	focus	VERB
admet-733	152	5	on	on	ADP
admet-733	152	6	fragments	fragment	NOUN
admet-733	152	7	with	with	ADP
admet-733	152	8	lower	low	ADJ
admet-733	152	9	heavy	heavy	ADJ
admet-733	152	10	atom	atom	NOUN
admet-733	152	11	counts	count	NOUN
admet-733	152	12	with	with	ADP
admet-733	152	13	the	the	DET
admet-733	152	14	most	most	ADV
admet-733	152	15	sensitive	sensitive	ADJ
admet-733	152	16	biophysical	biophysical	ADJ
admet-733	152	17	screening	screening	NOUN
admet-733	152	18	methods	method	NOUN
admet-733	152	19	provides	provide	VERB
admet-733	152	20	the	the	DET
admet-733	152	21	highest	high	ADJ
admet-733	152	22	probability	probability	NOUN
admet-733	152	23	of	of	ADP
admet-733	152	24	success	success	NOUN
admet-733	152	25	.	.	PUNCT
admet-733	153	1	nmr	nmr	NOUN
admet-733	153	2	is	be	AUX
admet-733	153	3	well	well	ADV
admet-733	153	4	-	-	PUNCT
admet-733	153	5	suited	suit	VERB
admet-733	153	6	for	for	ADP
admet-733	153	7	fragment	fragment	ADJ
admet-733	153	8	screening	screening	NOUN
admet-733	153	9	,	,	PUNCT
admet-733	153	10	as	as	SCONJ
admet-733	153	11	it	it	PRON
admet-733	153	12	can	can	AUX
admet-733	153	13	detect	detect	VERB
admet-733	153	14	binding	bind	VERB
admet-733	153	15	for	for	ADP
admet-733	153	16	fragments	fragment	NOUN
admet-733	153	17	having	have	VERB
admet-733	153	18	millimolar	millimolar	ADJ
admet-733	153	19	kd	kd	NOUN
admet-733	153	20	values	value	NOUN
admet-733	153	21	.	.	PUNCT
admet-733	154	1	two	two	NUM
admet-733	154	2	general	general	ADJ
admet-733	154	3	approaches	approach	NOUN
admet-733	154	4	may	may	AUX
admet-733	154	5	be	be	AUX
admet-733	154	6	applied	apply	VERB
admet-733	154	7	for	for	ADP
admet-733	154	8	proton	proton	NOUN
admet-733	154	9	nmr	nmr	NOUN
admet-733	154	10	-	-	PUNCT
admet-733	154	11	based	base	VERB
admet-733	154	12	screening	screening	NOUN
admet-733	154	13	,	,	PUNCT
admet-733	154	14	which	which	PRON
admet-733	154	15	monitor	monitor	VERB
admet-733	154	16	either	either	CCONJ
admet-733	154	17	differences	difference	NOUN
admet-733	154	18	in	in	ADP
admet-733	154	19	the	the	DET
admet-733	154	20	spectra	spectra	NOUN
admet-733	154	21	of	of	ADP
admet-733	154	22	the	the	DET
admet-733	154	23	small	small	ADJ
admet-733	154	24	molecules	molecule	NOUN
admet-733	154	25	or	or	CCONJ
admet-733	154	26	the	the	DET
admet-733	154	27	protein	protein	NOUN
admet-733	154	28	.	.	PUNCT
admet-733	155	1	ligand	ligand	NOUN
admet-733	155	2	-	-	PUNCT
admet-733	155	3	based	base	VERB
admet-733	155	4	screening	screening	NOUN
admet-733	155	5	methods	method	NOUN
admet-733	155	6	are	be	AUX
admet-733	155	7	often	often	ADV
admet-733	155	8	used	use	VERB
admet-733	155	9	for	for	ADP
admet-733	155	10	medium	medium	ADJ
admet-733	155	11	-	-	PUNCT
admet-733	155	12	sized	sized	ADJ
admet-733	155	13	proteins	protein	NOUN
admet-733	155	14	but	but	CCONJ
admet-733	155	15	work	work	VERB
admet-733	155	16	better	well	ADV
admet-733	155	17	with	with	ADP
admet-733	155	18	larger	large	ADJ
admet-733	155	19	target	target	NOUN
admet-733	155	20	proteins	protein	NOUN
admet-733	155	21	.	.	PUNCT
admet-733	156	1	no	no	DET
admet-733	156	2	isotope	isotope	NOUN
admet-733	156	3	labelling	labelling	NOUN
admet-733	156	4	is	be	AUX
admet-733	156	5	needed	need	VERB
admet-733	156	6	,	,	PUNCT
admet-733	156	7	and	and	CCONJ
admet-733	156	8	the	the	DET
admet-733	156	9	quantity	quantity	NOUN
admet-733	156	10	of	of	ADP
admet-733	156	11	protein	protein	NOUN
admet-733	156	12	required	require	VERB
admet-733	156	13	is	be	AUX
admet-733	156	14	relatively	relatively	ADV
admet-733	156	15	small	small	ADJ
admet-733	156	16	.	.	PUNCT
admet-733	157	1	another	another	DET
admet-733	157	2	advantage	advantage	NOUN
admet-733	157	3	is	be	AUX
admet-733	157	4	that	that	SCONJ
admet-733	157	5	when	when	SCONJ
admet-733	157	6	ligand	ligand	NOUN
admet-733	157	7	-	-	PUNCT
admet-733	157	8	observed	observe	VERB
admet-733	157	9	screens	screen	NOUN
admet-733	157	10	are	be	AUX
admet-733	157	11	undertaken	undertake	VERB
admet-733	157	12	,	,	PUNCT
admet-733	157	13	knowledge	knowledge	NOUN
admet-733	157	14	of	of	ADP
admet-733	157	15	the	the	DET
admet-733	157	16	chemical	chemical	NOUN
admet-733	157	17	shift	shift	NOUN
admet-733	157	18	pattern	pattern	NOUN
admet-733	157	19	for	for	ADP
admet-733	157	20	each	each	DET
admet-733	157	21	ligand	ligand	NOUN
admet-733	157	22	avoids	avoid	VERB
admet-733	157	23	the	the	DET
admet-733	157	24	necessity	necessity	NOUN
admet-733	157	25	for	for	ADP
admet-733	157	26	deconvolution	deconvolution	NOUN
admet-733	157	27	.	.	PUNCT
admet-733	158	1	disadvantages	disadvantage	NOUN
admet-733	158	2	of	of	ADP
admet-733	158	3	direct	direct	ADJ
admet-733	158	4	-	-	PUNCT
admet-733	158	5	detection	detection	NOUN
admet-733	158	6	ligandbased	ligandbased	ADJ
admet-733	158	7	screens	screen	NOUN
admet-733	158	8	are	be	AUX
admet-733	158	9	that	that	DET
admet-733	158	10	ligand	ligand	NOUN
admet-733	158	11	-	-	PUNCT
admet-733	158	12	based	base	VERB
admet-733	158	13	screening	screening	NOUN
admet-733	158	14	does	do	AUX
admet-733	158	15	not	not	PART
admet-733	158	16	provide	provide	VERB
admet-733	158	17	information	information	NOUN
admet-733	158	18	on	on	ADP
admet-733	158	19	the	the	DET
admet-733	158	20	binding	bind	VERB
admet-733	158	21	site	site	NOUN
admet-733	158	22	,	,	PUNCT
admet-733	158	23	and	and	CCONJ
admet-733	158	24	often	often	ADV
admet-733	158	25	false	false	ADJ
admet-733	158	26	positive	positive	ADJ
admet-733	158	27	rates	rate	NOUN
admet-733	158	28	may	may	AUX
admet-733	158	29	be	be	AUX
admet-733	158	30	greater	great	ADJ
admet-733	158	31	than	than	ADP
admet-733	158	32	with	with	ADP
admet-733	158	33	protein	protein	NOUN
admet-733	158	34	-	-	PUNCT
admet-733	158	35	observed	observe	VERB
admet-733	158	36	methods	method	NOUN
admet-733	158	37	,	,	PUNCT
admet-733	158	38	as	as	SCONJ
admet-733	158	39	it	it	PRON
admet-733	158	40	is	be	AUX
admet-733	158	41	sometimes	sometimes	ADV
admet-733	158	42	difficult	difficult	ADJ
admet-733	158	43	to	to	PART
admet-733	158	44	discriminate	discriminate	VERB
admet-733	158	45	between	between	ADP
admet-733	158	46	promiscuous	promiscuous	ADJ
admet-733	158	47	,	,	PUNCT
admet-733	158	48	non	non	ADJ
admet-733	158	49	-	-	ADJ
admet-733	158	50	specific	specific	ADJ
admet-733	158	51	binding	binding	NOUN
admet-733	158	52	due	due	ADP
admet-733	158	53	to	to	ADP
admet-733	158	54	compound	compound	NOUN
admet-733	158	55	aggregation	aggregation	NOUN
admet-733	158	56	and	and	CCONJ
admet-733	158	57	site	site	NOUN
admet-733	158	58	-	-	PUNCT
admet-733	158	59	specific	specific	ADJ
admet-733	158	60	binding	binding	NOUN
admet-733	158	61	.	.	PUNCT
admet-733	159	1	finally	finally	ADV
admet-733	159	2	,	,	PUNCT
admet-733	159	3	and	and	CCONJ
admet-733	159	4	almost	almost	ADV
admet-733	159	5	uniquely	uniquely	ADV
admet-733	159	6	for	for	ADP
admet-733	159	7	biophysical	biophysical	ADJ
admet-733	159	8	methods	method	NOUN
admet-733	159	9	,	,	PUNCT
admet-733	159	10	ligand	ligand	NOUN
admet-733	159	11	-	-	PUNCT
admet-733	159	12	based	base	VERB
admet-733	159	13	nmr	nmr	NOUN
admet-733	159	14	screening	screening	NOUN
admet-733	159	15	becomes	become	VERB
admet-733	159	16	challenging	challenge	VERB
admet-733	159	17	when	when	SCONJ
admet-733	159	18	binding	bind	VERB
admet-733	159	19	is	be	AUX
admet-733	159	20	too	too	ADV
admet-733	159	21	tight	tight	ADJ
admet-733	159	22	.	.	PUNCT
admet-733	160	1	these	these	DET
admet-733	160	2	issues	issue	NOUN
admet-733	160	3	can	can	AUX
admet-733	160	4	be	be	AUX
admet-733	160	5	overcome	overcome	VERB
admet-733	160	6	by	by	ADP
admet-733	160	7	using	use	VERB
admet-733	160	8	a	a	DET
admet-733	160	9	reporter	reporter	NOUN
admet-733	160	10	or	or	CCONJ
admet-733	160	11	“	"	PUNCT
admet-733	160	12	spy	spy	NOUN
admet-733	160	13	-	-	PUNCT
admet-733	160	14	molecule	molecule	NOUN
admet-733	160	15	”	"	PUNCT
admet-733	160	16	in	in	ADP
admet-733	160	17	the	the	DET
admet-733	160	18	nmr	nmr	NOUN
admet-733	160	19	experiment	experiment	NOUN
admet-733	160	20	.	.	PUNCT
admet-733	161	1	however	however	ADV
admet-733	161	2	,	,	PUNCT
admet-733	161	3	this	this	PRON
admet-733	161	4	requires	require	VERB
admet-733	161	5	that	that	SCONJ
admet-733	161	6	such	such	DET
admet-733	161	7	a	a	DET
admet-733	161	8	ligand	ligand	NOUN
admet-733	161	9	is	be	AUX
admet-733	161	10	available	available	ADJ
admet-733	161	11	when	when	SCONJ
admet-733	161	12	the	the	DET
admet-733	161	13	assay	assay	NOUN
admet-733	161	14	is	be	AUX
admet-733	161	15	developed	develop	VERB
admet-733	161	16	and	and	CCONJ
admet-733	161	17	has	have	VERB
admet-733	161	18	the	the	DET
admet-733	161	19	disadvantage	disadvantage	NOUN
admet-733	161	20	that	that	PRON
admet-733	161	21	compounds	compound	VERB
admet-733	161	22	binding	bind	VERB
admet-733	161	23	at	at	ADP
admet-733	161	24	a	a	DET
admet-733	161	25	non	non	ADJ
admet-733	161	26	-	-	ADJ
admet-733	161	27	overlapping	overlapping	ADJ
admet-733	161	28	site	site	NOUN
admet-733	161	29	may	may	AUX
admet-733	161	30	be	be	AUX
admet-733	161	31	missed	miss	VERB
admet-733	161	32	.	.	PUNCT
admet-733	162	1	probably	probably	ADV
admet-733	162	2	the	the	DET
admet-733	162	3	most	most	ADV
admet-733	162	4	robust	robust	ADJ
admet-733	162	5	fragment	fragment	NOUN
admet-733	162	6	screening	screening	NOUN
admet-733	162	7	method	method	NOUN
admet-733	162	8	is	be	AUX
admet-733	162	9	protein	protein	NOUN
admet-733	162	10	-	-	PUNCT
admet-733	162	11	observed	observe	VERB
admet-733	162	12	nmr	nmr	NOUN
admet-733	162	13	,	,	PUNCT
admet-733	162	14	where	where	SCONJ
admet-733	162	15	changes	change	NOUN
admet-733	162	16	in	in	ADP
admet-733	162	17	chemical	chemical	ADJ
admet-733	162	18	shift	shift	NOUN
admet-733	162	19	for	for	ADP
admet-733	162	20	an	an	DET
admet-733	162	21	isotopically	isotopically	ADV
admet-733	162	22	labelled	label	VERB
admet-733	162	23	protein	protein	NOUN
admet-733	162	24	are	be	AUX
admet-733	162	25	monitored	monitor	VERB
admet-733	162	26	.	.	PUNCT
admet-733	163	1	the	the	DET
admet-733	163	2	advantage	advantage	NOUN
admet-733	163	3	of	of	ADP
admet-733	163	4	using	use	VERB
admet-733	163	5	this	this	DET
admet-733	163	6	method	method	NOUN
admet-733	163	7	is	be	AUX
admet-733	163	8	that	that	SCONJ
admet-733	163	9	not	not	PART
admet-733	163	10	only	only	ADV
admet-733	163	11	can	can	AUX
admet-733	163	12	hits	hit	NOUN
admet-733	163	13	be	be	AUX
admet-733	163	14	detected	detect	VERB
admet-733	163	15	,	,	PUNCT
admet-733	163	16	but	but	CCONJ
admet-733	163	17	affinities	affinity	NOUN
admet-733	163	18	can	can	AUX
admet-733	163	19	be	be	AUX
admet-733	163	20	determined	determine	VERB
admet-733	163	21	,	,	PUNCT
admet-733	163	22	and	and	CCONJ
admet-733	163	23	binding	bind	VERB
admet-733	163	24	sites	site	NOUN
admet-733	163	25	identified	identify	VERB
admet-733	163	26	if	if	SCONJ
admet-733	163	27	the	the	DET
admet-733	163	28	protein	protein	NOUN
admet-733	163	29	signals	signal	NOUN
admet-733	163	30	have	have	AUX
admet-733	163	31	been	be	AUX
admet-733	163	32	assigned	assign	VERB
admet-733	163	33	.	.	PUNCT
admet-733	164	1	this	this	DET
admet-733	164	2	method	method	NOUN
admet-733	164	3	is	be	AUX
admet-733	164	4	suitable	suitable	ADJ
admet-733	164	5	for	for	ADP
admet-733	164	6	proteins	protein	NOUN
admet-733	164	7	of	of	ADP
admet-733	164	8	around	around	ADV
admet-733	164	9	10	10	NUM
admet-733	164	10	–	–	SYM
admet-733	164	11	50	50	NUM
admet-733	164	12	kda	kda	NOUN
admet-733	164	13	providing	provide	VERB
admet-733	164	14	that	that	SCONJ
admet-733	164	15	uniformly	uniformly	ADV
admet-733	164	16	15n	15n	NOUN
admet-733	164	17	-	-	PUNCT
admet-733	164	18	labeled	label	VERB
admet-733	164	19	protein	protein	NOUN
admet-733	164	20	can	can	AUX
admet-733	164	21	be	be	AUX
admet-733	164	22	obtained	obtain	VERB
admet-733	164	23	.	.	PUNCT
admet-733	165	1	a	a	DET
admet-733	165	2	detailed	detailed	ADJ
admet-733	165	3	description	description	NOUN
admet-733	165	4	of	of	ADP
admet-733	165	5	the	the	DET
admet-733	165	6	application	application	NOUN
admet-733	165	7	of	of	ADP
admet-733	165	8	different	different	ADJ
admet-733	165	9	ligand	ligand	NOUN
admet-733	165	10	and	and	CCONJ
admet-733	165	11	protein	protein	NOUN
admet-733	165	12	observed	observe	VERB
admet-733	165	13	nmr	nmr	NOUN
admet-733	165	14	methods	method	NOUN
admet-733	165	15	in	in	ADP
admet-733	165	16	fragment	fragment	NOUN
admet-733	165	17	-	-	PUNCT
admet-733	165	18	based	base	VERB
admet-733	165	19	screening	screening	NOUN
admet-733	165	20	is	be	AUX
admet-733	165	21	beyond	beyond	ADP
admet-733	165	22	the	the	DET
admet-733	165	23	scope	scope	NOUN
admet-733	165	24	of	of	ADP
admet-733	165	25	this	this	DET
admet-733	165	26	article	article	NOUN
admet-733	165	27	,	,	PUNCT
admet-733	165	28	but	but	CCONJ
admet-733	165	29	a	a	DET
admet-733	165	30	valuable	valuable	ADJ
admet-733	165	31	overview	overview	NOUN
admet-733	165	32	is	be	AUX
admet-733	165	33	given	give	VERB
admet-733	165	34	by	by	ADP
admet-733	165	35	harner	harner	PROPN
admet-733	165	36	et	et	PROPN
admet-733	165	37	al	al	PROPN
admet-733	166	1	[	[	X
admet-733	166	2	28	28	NUM
admet-733	166	3	]	]	PUNCT
admet-733	166	4	.	.	PUNCT
admet-733	167	1	since	since	SCONJ
admet-733	167	2	fragments	fragment	NOUN
admet-733	167	3	usually	usually	ADV
admet-733	167	4	have	have	VERB
admet-733	167	5	weak	weak	ADJ
admet-733	167	6	binding	bind	VERB
admet-733	167	7	affinities	affinity	NOUN
admet-733	167	8	,	,	PUNCT
admet-733	167	9	they	they	PRON
admet-733	167	10	are	be	AUX
admet-733	167	11	almost	almost	ADV
admet-733	167	12	always	always	ADV
admet-733	167	13	in	in	ADP
admet-733	167	14	the	the	DET
admet-733	167	15	fast	fast	ADJ
admet-733	167	16	exchange	exchange	NOUN
admet-733	167	17	regime	regime	NOUN
admet-733	167	18	,	,	PUNCT
admet-733	167	19	and	and	CCONJ
admet-733	167	20	kd	kd	PROPN
admet-733	167	21	values	value	NOUN
admet-733	167	22	can	can	AUX
admet-733	167	23	be	be	AUX
admet-733	167	24	calculated	calculate	VERB
admet-733	167	25	from	from	ADP
admet-733	167	26	changes	change	NOUN
admet-733	167	27	in	in	ADP
admet-733	167	28	chemical	chemical	ADJ
admet-733	167	29	shifts	shift	NOUN
admet-733	167	30	with	with	ADP
admet-733	167	31	increasing	increase	VERB
admet-733	167	32	fragment	fragment	ADJ
admet-733	167	33	concentration	concentration	NOUN
admet-733	167	34	.	.	PUNCT
admet-733	168	1	however	however	ADV
admet-733	168	2	,	,	PUNCT
admet-733	168	3	if	if	SCONJ
admet-733	168	4	fragment	fragment	ADJ
admet-733	168	5	binding	bind	VERB
admet-733	168	6	affinity	affinity	NOUN
admet-733	168	7	is	be	AUX
admet-733	168	8	higher	high	ADJ
admet-733	168	9	or	or	CCONJ
admet-733	168	10	fragment	fragment	ADJ
admet-733	168	11	optimisation	optimisation	NOUN
admet-733	168	12	leads	lead	VERB
admet-733	168	13	to	to	ADP
admet-733	168	14	compounds	compound	NOUN
admet-733	168	15	that	that	PRON
admet-733	168	16	have	have	AUX
admet-733	168	17	improved	improve	VERB
admet-733	168	18	affinity	affinity	NOUN
admet-733	168	19	(	(	PUNCT
admet-733	168	20	for	for	ADP
admet-733	168	21	example	example	NOUN
admet-733	168	22	kds	kds	PROPN
admet-733	168	23	of	of	ADP
admet-733	168	24	the	the	DET
admet-733	168	25	order	order	NOUN
admet-733	168	26	of	of	ADP
admet-733	168	27	10	10	NUM
admet-733	168	28	50	50	NUM
admet-733	168	29	μm	μm	NOUN
admet-733	168	30	)	)	PUNCT
admet-733	168	31	then	then	ADV
admet-733	168	32	intermediate	intermediate	ADJ
admet-733	168	33	exchange	exchange	NOUN
admet-733	168	34	of	of	ADP
admet-733	168	35	resonances	resonance	NOUN
admet-733	168	36	can	can	AUX
admet-733	168	37	become	become	VERB
admet-733	168	38	a	a	DET
admet-733	168	39	problem	problem	NOUN
admet-733	168	40	,	,	PUNCT
admet-733	168	41	with	with	SCONJ
admet-733	168	42	resonances	resonance	NOUN
admet-733	168	43	broadening	broaden	VERB
admet-733	168	44	and	and	CCONJ
admet-733	168	45	disappearing	disappear	VERB
admet-733	168	46	and	and	CCONJ
admet-733	168	47	nmr	nmr	NOUN
admet-733	168	48	is	be	AUX
admet-733	168	49	no	no	ADV
admet-733	168	50	longer	long	ADV
admet-733	168	51	useful	useful	ADJ
admet-733	168	52	for	for	ADP
admet-733	168	53	kd	kd	PROPN
admet-733	168	54	determinations	determination	NOUN
admet-733	168	55	.	.	PUNCT
admet-733	169	1	at	at	ADP
admet-733	169	2	this	this	DET
admet-733	169	3	point	point	NOUN
admet-733	169	4	,	,	PUNCT
admet-733	169	5	other	other	ADJ
admet-733	169	6	biophysical	biophysical	ADJ
admet-733	169	7	techniques	technique	NOUN
admet-733	169	8	such	such	ADJ
admet-733	169	9	as	as	ADP
admet-733	169	10	itc	itc	PROPN
admet-733	169	11	and	and	CCONJ
admet-733	169	12	spr	spr	NOUN
admet-733	169	13	are	be	AUX
admet-733	169	14	often	often	ADV
admet-733	169	15	used	use	VERB
admet-733	169	16	to	to	PART
admet-733	169	17	measure	measure	VERB
admet-733	169	18	affinity	affinity	NOUN
admet-733	169	19	.	.	PUNCT
admet-733	170	1	holdgate	holdgate	VERB
admet-733	170	2	et	et	PROPN
admet-733	170	3	al	al	PROPN
admet-733	170	4	.	.	PROPN
admet-733	170	5	admet	admet	PROPN
admet-733	170	6	&	&	CCONJ
admet-733	170	7	dmpk	dmpk	PROPN
admet-733	170	8	7(4	7(4	NUM
admet-733	170	9	)	)	PUNCT
admet-733	170	10	(	(	PUNCT
admet-733	170	11	2019	2019	NUM
admet-733	170	12	)	)	PUNCT
admet-733	170	13	222	222	NUM
admet-733	170	14	-	-	SYM
admet-733	170	15	241	241	NUM
admet-733	170	16	232	232	NUM
admet-733	170	17	spr	spr	NOUN
admet-733	170	18	can	can	AUX
admet-733	170	19	also	also	ADV
admet-733	170	20	be	be	AUX
admet-733	170	21	applied	apply	VERB
admet-733	170	22	to	to	ADP
admet-733	170	23	primary	primary	ADJ
admet-733	170	24	fragment	fragment	NOUN
admet-733	170	25	screening	screening	NOUN
admet-733	170	26	,	,	PUNCT
admet-733	170	27	and	and	CCONJ
admet-733	170	28	many	many	ADJ
admet-733	170	29	of	of	ADP
admet-733	170	30	the	the	DET
admet-733	170	31	technical	technical	ADJ
admet-733	170	32	practical	practical	ADJ
admet-733	170	33	challenges	challenge	NOUN
admet-733	170	34	including	include	VERB
admet-733	170	35	working	work	VERB
admet-733	170	36	with	with	ADP
admet-733	170	37	low	low	ADJ
admet-733	170	38	-	-	PUNCT
admet-733	170	39	molecular	molecular	ADJ
admet-733	170	40	weights	weight	NOUN
admet-733	170	41	compounds	compound	NOUN
admet-733	170	42	with	with	ADP
admet-733	170	43	limited	limited	ADJ
admet-733	170	44	solubility	solubility	NOUN
admet-733	170	45	and	and	CCONJ
admet-733	170	46	showing	show	VERB
admet-733	170	47	low	low	ADJ
admet-733	170	48	-	-	PUNCT
admet-733	170	49	affinity	affinity	NOUN
admet-733	170	50	interactions	interaction	NOUN
admet-733	170	51	in	in	ADP
admet-733	170	52	high	high	ADJ
admet-733	170	53	refractive	refractive	ADJ
admet-733	170	54	index	index	NOUN
admet-733	170	55	solvents	solvent	NOUN
admet-733	170	56	such	such	ADJ
admet-733	170	57	as	as	ADP
admet-733	170	58	dmso	dmso	NOUN
admet-733	170	59	have	have	AUX
admet-733	170	60	been	be	AUX
admet-733	170	61	addressed	address	VERB
admet-733	170	62	through	through	ADP
admet-733	170	63	appropriate	appropriate	ADJ
admet-733	170	64	assay	assay	NOUN
admet-733	170	65	design	design	NOUN
admet-733	170	66	and	and	CCONJ
admet-733	170	67	control	control	NOUN
admet-733	170	68	experiments	experiment	NOUN
admet-733	170	69	.	.	PUNCT
admet-733	171	1	improvements	improvement	NOUN
admet-733	171	2	in	in	ADP
admet-733	171	3	instrumentation	instrumentation	NOUN
admet-733	171	4	and	and	CCONJ
admet-733	171	5	data	datum	NOUN
admet-733	171	6	analysis	analysis	NOUN
admet-733	171	7	procedures	procedure	NOUN
admet-733	171	8	have	have	AUX
admet-733	171	9	also	also	ADV
admet-733	171	10	helped	help	VERB
admet-733	171	11	to	to	PART
admet-733	171	12	position	position	VERB
admet-733	171	13	spr	spr	ADV
admet-733	171	14	alongside	alongside	ADP
admet-733	171	15	nmr	nmr	NOUN
admet-733	171	16	in	in	ADP
admet-733	171	17	the	the	DET
admet-733	171	18	consideration	consideration	NOUN
admet-733	171	19	of	of	ADP
admet-733	171	20	methods	method	NOUN
admet-733	171	21	for	for	ADP
admet-733	171	22	delivering	deliver	VERB
admet-733	171	23	fragment	fragment	NOUN
admet-733	171	24	screening	screening	NOUN
admet-733	171	25	hits	hit	NOUN
admet-733	171	26	[	[	X
admet-733	171	27	29	29	NUM
admet-733	171	28	]	]	PUNCT
admet-733	171	29	.	.	PUNCT
admet-733	172	1	immobilisation	immobilisation	NOUN
admet-733	172	2	of	of	ADP
admet-733	172	3	the	the	DET
admet-733	172	4	target	target	NOUN
admet-733	172	5	protein	protein	NOUN
admet-733	172	6	in	in	ADP
admet-733	172	7	a	a	DET
admet-733	172	8	functional	functional	ADJ
admet-733	172	9	manner	manner	NOUN
admet-733	172	10	is	be	AUX
admet-733	172	11	still	still	ADV
admet-733	172	12	a	a	DET
admet-733	172	13	key	key	ADJ
admet-733	172	14	factor	factor	NOUN
admet-733	172	15	,	,	PUNCT
admet-733	172	16	and	and	CCONJ
admet-733	172	17	several	several	ADJ
admet-733	172	18	different	different	ADJ
admet-733	172	19	strategies	strategy	NOUN
admet-733	172	20	may	may	AUX
admet-733	172	21	need	need	VERB
admet-733	172	22	to	to	PART
admet-733	172	23	be	be	AUX
admet-733	172	24	explored	explore	VERB
admet-733	172	25	.	.	PUNCT
admet-733	173	1	our	our	PRON
admet-733	173	2	experience	experience	NOUN
admet-733	173	3	suggests	suggest	VERB
admet-733	173	4	that	that	SCONJ
admet-733	173	5	use	use	NOUN
admet-733	173	6	of	of	ADP
admet-733	173	7	an	an	DET
admet-733	173	8	avitagtm	avitagtm	NOUN
admet-733	173	9	(	(	PUNCT
admet-733	173	10	avidity	avidity	NOUN
admet-733	173	11	llc	llc	PROPN
admet-733	173	12	)	)	PUNCT
admet-733	174	1	[	[	X
admet-733	174	2	30	30	NUM
admet-733	174	3	]	]	PUNCT
admet-733	174	4	with	with	ADP
admet-733	174	5	coupling	coupling	NOUN
admet-733	174	6	via	via	ADP
admet-733	174	7	biotinylation	biotinylation	NOUN
admet-733	174	8	of	of	ADP
admet-733	174	9	the	the	DET
admet-733	174	10	tagged	tag	VERB
admet-733	174	11	protein	protein	NOUN
admet-733	174	12	and	and	CCONJ
admet-733	174	13	capture	capture	VERB
admet-733	174	14	on	on	ADP
admet-733	174	15	a	a	DET
admet-733	174	16	streptavidin	streptavidin	NOUN
admet-733	174	17	chip	chip	NOUN
admet-733	174	18	often	often	ADV
admet-733	174	19	produces	produce	VERB
admet-733	174	20	a	a	DET
admet-733	174	21	suitable	suitable	ADJ
admet-733	174	22	surface	surface	NOUN
admet-733	174	23	for	for	ADP
admet-733	174	24	fragment	fragment	ADJ
admet-733	174	25	screening	screening	NOUN
admet-733	174	26	,	,	PUNCT
admet-733	174	27	and	and	CCONJ
admet-733	174	28	subsequent	subsequent	ADJ
admet-733	174	29	characterisation	characterisation	NOUN
admet-733	174	30	.	.	PUNCT
admet-733	175	1	issues	issue	NOUN
admet-733	175	2	with	with	ADP
admet-733	175	3	potential	potential	ADJ
admet-733	175	4	fragment	fragment	NOUN
admet-733	175	5	binding	bind	VERB
admet-733	175	6	to	to	ADP
admet-733	175	7	the	the	DET
admet-733	175	8	streptavidin	streptavidin	NOUN
admet-733	175	9	are	be	AUX
admet-733	175	10	usually	usually	ADV
admet-733	175	11	overcome	overcome	VERB
admet-733	175	12	by	by	ADP
admet-733	175	13	blocking	block	VERB
admet-733	175	14	with	with	ADP
admet-733	175	15	suitable	suitable	ADJ
admet-733	175	16	biotin	biotin	NOUN
admet-733	175	17	analogues	analogue	NOUN
admet-733	175	18	.	.	PUNCT
admet-733	176	1	other	other	ADJ
admet-733	176	2	tagging	tagging	NOUN
admet-733	176	3	approaches	approach	NOUN
admet-733	176	4	for	for	ADP
admet-733	176	5	immobilisation	immobilisation	NOUN
admet-733	176	6	have	have	AUX
admet-733	176	7	been	be	AUX
admet-733	176	8	used	use	VERB
admet-733	176	9	successfully	successfully	ADV
admet-733	176	10	to	to	PART
admet-733	176	11	capture	capture	VERB
admet-733	176	12	membrane	membrane	NOUN
admet-733	176	13	proteins	protein	NOUN
admet-733	176	14	,	,	PUNCT
admet-733	176	15	providing	provide	VERB
admet-733	176	16	the	the	DET
admet-733	176	17	possibility	possibility	NOUN
admet-733	176	18	of	of	ADP
admet-733	176	19	using	use	VERB
admet-733	176	20	fbdd	fbdd	NOUN
admet-733	176	21	versus	versus	ADP
admet-733	176	22	members	member	NOUN
admet-733	176	23	of	of	ADP
admet-733	176	24	this	this	DET
admet-733	176	25	important	important	ADJ
admet-733	176	26	class	class	NOUN
admet-733	176	27	of	of	ADP
admet-733	176	28	drug	drug	NOUN
admet-733	176	29	targets	target	NOUN
admet-733	176	30	,	,	PUNCT
admet-733	176	31	such	such	ADJ
admet-733	176	32	as	as	ADP
admet-733	176	33	g	g	NOUN
admet-733	176	34	-	-	PUNCT
admet-733	176	35	protein	protein	NOUN
admet-733	176	36	coupled	couple	VERB
admet-733	176	37	receptors	receptor	NOUN
admet-733	176	38	(	(	PUNCT
admet-733	176	39	gpcrs	gpcrs	PROPN
admet-733	176	40	)	)	PUNCT
admet-733	177	1	[	[	X
admet-733	177	2	31	31	NUM
admet-733	177	3	]	]	PUNCT
admet-733	177	4	.	.	PUNCT
admet-733	178	1	as	as	SCONJ
admet-733	178	2	mentioned	mention	VERB
admet-733	178	3	previously	previously	ADV
admet-733	178	4	,	,	PUNCT
admet-733	178	5	fragment	fragment	ADJ
admet-733	178	6	screening	screening	NOUN
admet-733	178	7	using	use	VERB
admet-733	178	8	tsa	tsa	NOUN
admet-733	178	9	has	have	AUX
admet-733	178	10	also	also	ADV
admet-733	178	11	proved	prove	VERB
admet-733	178	12	to	to	PART
admet-733	178	13	be	be	AUX
admet-733	178	14	a	a	DET
admet-733	178	15	useful	useful	ADJ
admet-733	178	16	approach	approach	NOUN
admet-733	178	17	,	,	PUNCT
admet-733	178	18	and	and	CCONJ
admet-733	178	19	has	have	AUX
admet-733	178	20	been	be	AUX
admet-733	178	21	exemplified	exemplify	VERB
admet-733	178	22	as	as	ADP
admet-733	178	23	a	a	DET
admet-733	178	24	primary	primary	ADJ
admet-733	178	25	fragment	fragment	NOUN
admet-733	178	26	screen	screen	NOUN
admet-733	178	27	,	,	PUNCT
admet-733	178	28	with	with	ADP
admet-733	178	29	detailed	detailed	ADJ
admet-733	178	30	biophysical	biophysical	ADJ
admet-733	178	31	follow	follow	NOUN
admet-733	178	32	up	up	ADP
admet-733	178	33	,	,	PUNCT
admet-733	178	34	for	for	ADP
admet-733	178	35	identifying	identify	VERB
admet-733	178	36	fragment	fragment	NOUN
admet-733	178	37	hits	hit	NOUN
admet-733	178	38	with	with	ADP
admet-733	178	39	the	the	DET
admet-733	178	40	potential	potential	NOUN
admet-733	178	41	for	for	ADP
admet-733	178	42	disrupting	disrupt	VERB
admet-733	178	43	protein	protein	NOUN
admet-733	178	44	-	-	PUNCT
admet-733	178	45	protein	protein	NOUN
admet-733	178	46	interactions	interaction	NOUN
admet-733	178	47	(	(	PUNCT
admet-733	178	48	ppis	ppis	NOUN
admet-733	178	49	)	)	PUNCT
admet-733	179	1	[	[	X
admet-733	179	2	32	32	NUM
admet-733	179	3	]	]	PUNCT
admet-733	179	4	.	.	PUNCT
admet-733	180	1	this	this	DET
admet-733	180	2	method	method	NOUN
admet-733	180	3	,	,	PUNCT
admet-733	180	4	whilst	whilst	SCONJ
admet-733	180	5	not	not	PART
admet-733	180	6	being	be	AUX
admet-733	180	7	suitable	suitable	ADJ
admet-733	180	8	for	for	ADP
admet-733	180	9	membrane	membrane	ADJ
admet-733	180	10	proteins	protein	NOUN
admet-733	180	11	,	,	PUNCT
admet-733	180	12	has	have	VERB
admet-733	180	13	the	the	DET
admet-733	180	14	advantage	advantage	NOUN
admet-733	180	15	of	of	ADP
admet-733	180	16	not	not	PART
admet-733	180	17	requiring	require	VERB
admet-733	180	18	immobilisation	immobilisation	NOUN
admet-733	180	19	or	or	CCONJ
admet-733	180	20	labelling	labelling	NOUN
admet-733	180	21	of	of	ADP
admet-733	180	22	the	the	DET
admet-733	180	23	protein	protein	NOUN
admet-733	180	24	,	,	PUNCT
admet-733	180	25	and	and	CCONJ
admet-733	180	26	so	so	ADV
admet-733	180	27	may	may	AUX
admet-733	180	28	be	be	AUX
admet-733	180	29	more	more	ADV
admet-733	180	30	widely	widely	ADV
admet-733	180	31	applicable	applicable	ADJ
admet-733	180	32	to	to	ADP
admet-733	180	33	proteins	protein	NOUN
admet-733	180	34	that	that	PRON
admet-733	180	35	may	may	AUX
admet-733	180	36	be	be	AUX
admet-733	180	37	difficult	difficult	ADJ
admet-733	180	38	to	to	PART
admet-733	180	39	work	work	VERB
admet-733	180	40	with	with	ADP
admet-733	180	41	in	in	ADP
admet-733	180	42	nmr	nmr	NOUN
admet-733	180	43	or	or	CCONJ
admet-733	180	44	spr	spr	NOUN
admet-733	180	45	.	.	PUNCT
admet-733	180	46	microscale	microscale	ADJ
admet-733	180	47	thermophoresis	thermophoresis	NOUN
admet-733	180	48	(	(	PUNCT
admet-733	180	49	mst	mst	PROPN
admet-733	180	50	)	)	PUNCT
admet-733	181	1	[	[	X
admet-733	181	2	33	33	NUM
admet-733	181	3	]	]	PUNCT
admet-733	181	4	is	be	AUX
admet-733	181	5	a	a	DET
admet-733	181	6	developing	develop	VERB
admet-733	181	7	technique	technique	NOUN
admet-733	181	8	that	that	PRON
admet-733	181	9	has	have	AUX
admet-733	181	10	also	also	ADV
admet-733	181	11	been	be	AUX
admet-733	181	12	applied	apply	VERB
admet-733	181	13	for	for	ADP
admet-733	181	14	fragment	fragment	NOUN
admet-733	181	15	screening	screening	NOUN
admet-733	182	1	[	[	X
admet-733	182	2	34	34	NUM
admet-733	182	3	]	]	PUNCT
admet-733	182	4	.	.	PUNCT
admet-733	183	1	mst	mst	PROPN
admet-733	183	2	detects	detect	VERB
admet-733	183	3	the	the	DET
admet-733	183	4	movement	movement	NOUN
admet-733	183	5	of	of	ADP
admet-733	183	6	fluorescent	fluorescent	ADJ
admet-733	183	7	molecules	molecule	NOUN
admet-733	183	8	in	in	ADP
admet-733	183	9	a	a	DET
admet-733	183	10	microscopic	microscopic	ADJ
admet-733	183	11	temperature	temperature	NOUN
admet-733	183	12	gradient	gradient	NOUN
admet-733	183	13	created	create	VERB
admet-733	183	14	by	by	ADP
admet-733	183	15	focusing	focus	VERB
admet-733	183	16	an	an	DET
admet-733	183	17	infra	infra	NOUN
admet-733	183	18	-	-	PUNCT
admet-733	183	19	red	red	ADJ
admet-733	183	20	laser	laser	NOUN
admet-733	183	21	beam	beam	NOUN
admet-733	183	22	on	on	ADP
admet-733	183	23	a	a	DET
admet-733	183	24	section	section	NOUN
admet-733	183	25	of	of	ADP
admet-733	183	26	a	a	DET
admet-733	183	27	microliter	microliter	NOUN
admet-733	183	28	-	-	PUNCT
admet-733	183	29	volume	volume	NOUN
admet-733	183	30	capillary	capillary	NOUN
admet-733	183	31	.	.	PUNCT
admet-733	184	1	binding	bind	VERB
admet-733	184	2	of	of	ADP
admet-733	184	3	ligands	ligand	NOUN
admet-733	184	4	typically	typically	ADV
admet-733	184	5	changes	change	VERB
admet-733	184	6	the	the	DET
admet-733	184	7	size	size	NOUN
admet-733	184	8	,	,	PUNCT
admet-733	184	9	charge	charge	NOUN
admet-733	184	10	,	,	PUNCT
admet-733	184	11	and/or	and/or	CCONJ
admet-733	184	12	hydration	hydration	NOUN
admet-733	184	13	shell	shell	NOUN
admet-733	184	14	of	of	ADP
admet-733	184	15	the	the	DET
admet-733	184	16	target	target	NOUN
admet-733	184	17	protein	protein	NOUN
admet-733	184	18	,	,	PUNCT
admet-733	184	19	producing	produce	VERB
admet-733	184	20	a	a	DET
admet-733	184	21	change	change	NOUN
admet-733	184	22	in	in	ADP
admet-733	184	23	the	the	DET
admet-733	184	24	thermophoretic	thermophoretic	ADJ
admet-733	184	25	movement	movement	NOUN
admet-733	184	26	of	of	ADP
admet-733	184	27	the	the	DET
admet-733	184	28	protein	protein	NOUN
admet-733	184	29	.	.	PUNCT
admet-733	185	1	mst	mst	PROPN
admet-733	185	2	requires	require	VERB
admet-733	185	3	that	that	SCONJ
admet-733	185	4	the	the	DET
admet-733	185	5	position	position	NOUN
admet-733	185	6	of	of	ADP
admet-733	185	7	one	one	NUM
admet-733	185	8	binding	bind	VERB
admet-733	185	9	partner	partner	NOUN
admet-733	185	10	can	can	AUX
admet-733	185	11	be	be	AUX
admet-733	185	12	fluorescently	fluorescently	ADV
admet-733	185	13	monitored	monitor	VERB
admet-733	185	14	,	,	PUNCT
admet-733	185	15	so	so	CCONJ
admet-733	185	16	for	for	ADP
admet-733	185	17	screening	screen	VERB
admet-733	185	18	purposes	purpose	NOUN
admet-733	185	19	this	this	PRON
admet-733	185	20	is	be	AUX
admet-733	185	21	most	most	ADV
admet-733	185	22	likely	likely	ADJ
admet-733	185	23	the	the	DET
admet-733	185	24	target	target	NOUN
admet-733	185	25	protein	protein	NOUN
admet-733	185	26	.	.	PUNCT
admet-733	186	1	whilst	whilst	SCONJ
admet-733	186	2	this	this	PRON
admet-733	186	3	can	can	AUX
admet-733	186	4	potentially	potentially	ADV
admet-733	186	5	introduce	introduce	VERB
admet-733	186	6	artefacts	artefact	NOUN
admet-733	186	7	,	,	PUNCT
admet-733	186	8	and	and	CCONJ
admet-733	186	9	the	the	DET
admet-733	186	10	low	low	ADJ
admet-733	186	11	protein	protein	NOUN
admet-733	186	12	requirement	requirement	NOUN
admet-733	186	13	the	the	DET
admet-733	186	14	absence	absence	NOUN
admet-733	186	15	of	of	ADP
admet-733	186	16	a	a	DET
admet-733	186	17	need	need	NOUN
admet-733	186	18	for	for	ADP
admet-733	186	19	immobilisation	immobilisation	NOUN
admet-733	186	20	can	can	AUX
admet-733	186	21	position	position	VERB
admet-733	186	22	this	this	DET
admet-733	186	23	method	method	NOUN
admet-733	186	24	as	as	ADP
admet-733	186	25	useful	useful	ADJ
admet-733	186	26	approach	approach	NOUN
admet-733	186	27	if	if	SCONJ
admet-733	186	28	nmr	nmr	NOUN
admet-733	186	29	or	or	CCONJ
admet-733	186	30	spr	spr	NOUN
admet-733	186	31	can	can	AUX
admet-733	186	32	not	not	PART
admet-733	186	33	be	be	AUX
admet-733	186	34	used	use	VERB
admet-733	186	35	.	.	PUNCT
admet-733	187	1	fragment	fragment	NOUN
admet-733	187	2	screening	screening	NOUN
admet-733	187	3	is	be	AUX
admet-733	187	4	clearly	clearly	ADV
admet-733	187	5	amenable	amenable	ADJ
admet-733	187	6	to	to	ADP
admet-733	187	7	a	a	DET
admet-733	187	8	range	range	NOUN
admet-733	187	9	of	of	ADP
admet-733	187	10	biophysical	biophysical	ADJ
admet-733	187	11	methods	method	NOUN
admet-733	187	12	,	,	PUNCT
admet-733	187	13	due	due	ADJ
admet-733	187	14	in	in	ADP
admet-733	187	15	large	large	ADJ
admet-733	187	16	part	part	NOUN
admet-733	187	17	to	to	ADP
admet-733	187	18	the	the	DET
admet-733	187	19	reduced	reduce	VERB
admet-733	187	20	numbers	number	NOUN
admet-733	187	21	of	of	ADP
admet-733	187	22	compounds	compound	NOUN
admet-733	187	23	that	that	PRON
admet-733	187	24	are	be	AUX
admet-733	187	25	routinely	routinely	ADV
admet-733	187	26	tested	test	VERB
admet-733	187	27	.	.	PUNCT
admet-733	188	1	at	at	ADP
admet-733	188	2	astrazeneca	astrazeneca	PROPN
admet-733	188	3	the	the	DET
admet-733	188	4	fragment	fragment	NOUN
admet-733	188	5	library	library	NOUN
admet-733	188	6	consists	consist	VERB
admet-733	188	7	of	of	ADP
admet-733	188	8	a	a	DET
admet-733	188	9	soluble	soluble	ADJ
admet-733	188	10	set	set	NOUN
admet-733	188	11	of	of	ADP
admet-733	188	12	around	around	ADP
admet-733	188	13	14000	14000	NUM
admet-733	188	14	compounds	compound	NOUN
admet-733	188	15	.	.	PUNCT
admet-733	189	1	within	within	ADP
admet-733	189	2	that	that	PRON
admet-733	189	3	is	be	AUX
admet-733	189	4	contained	contain	VERB
admet-733	189	5	a	a	DET
admet-733	189	6	core	core	NOUN
admet-733	189	7	set	set	NOUN
admet-733	189	8	of	of	ADP
admet-733	189	9	3456	3456	NUM
admet-733	189	10	compounds	compound	NOUN
admet-733	189	11	which	which	PRON
admet-733	189	12	are	be	AUX
admet-733	189	13	routinely	routinely	ADV
admet-733	189	14	used	use	VERB
admet-733	189	15	for	for	ADP
admet-733	189	16	biophysical	biophysical	ADJ
admet-733	189	17	screening	screening	NOUN
admet-733	189	18	.	.	PUNCT
admet-733	190	1	this	this	DET
admet-733	190	2	library	library	NOUN
admet-733	190	3	is	be	AUX
admet-733	190	4	further	far	ADV
admet-733	190	5	divided	divide	VERB
admet-733	190	6	into	into	ADP
admet-733	190	7	a	a	DET
admet-733	190	8	soluble	soluble	ADJ
admet-733	190	9	set	set	NOUN
admet-733	190	10	used	use	VERB
admet-733	190	11	for	for	ADP
admet-733	190	12	spr	spr	ADJ
admet-733	190	13	screening	screening	NOUN
admet-733	190	14	of	of	ADP
admet-733	190	15	3072	3072	NUM
admet-733	190	16	compounds	compound	NOUN
admet-733	190	17	and	and	CCONJ
admet-733	190	18	a	a	DET
admet-733	190	19	simple	simple	ADJ
admet-733	190	20	set	set	NOUN
admet-733	190	21	of	of	ADP
admet-733	190	22	1152	1152	NUM
admet-733	190	23	compounds	compound	NOUN
admet-733	190	24	,	,	PUNCT
admet-733	190	25	which	which	PRON
admet-733	190	26	are	be	AUX
admet-733	190	27	often	often	ADV
admet-733	190	28	screened	screen	VERB
admet-733	190	29	by	by	ADP
admet-733	190	30	nmr	nmr	NOUN
admet-733	190	31	.	.	PUNCT
admet-733	191	1	there	there	PRON
admet-733	191	2	are	be	VERB
admet-733	191	3	768	768	NUM
admet-733	191	4	compounds	compound	NOUN
admet-733	191	5	that	that	PRON
admet-733	191	6	are	be	AUX
admet-733	191	7	common	common	ADJ
admet-733	191	8	to	to	ADP
admet-733	191	9	both	both	CCONJ
admet-733	191	10	the	the	DET
admet-733	191	11	soluble	soluble	ADJ
admet-733	191	12	and	and	CCONJ
admet-733	191	13	simple	simple	ADJ
admet-733	191	14	sets	set	NOUN
admet-733	191	15	.	.	PUNCT
admet-733	192	1	the	the	DET
admet-733	192	2	design	design	NOUN
admet-733	192	3	and	and	CCONJ
admet-733	192	4	usage	usage	NOUN
admet-733	192	5	principles	principle	NOUN
admet-733	192	6	behind	behind	ADP
admet-733	192	7	these	these	DET
admet-733	192	8	sets	set	NOUN
admet-733	192	9	were	be	AUX
admet-733	192	10	that	that	SCONJ
admet-733	192	11	all	all	DET
admet-733	192	12	compounds	compound	NOUN
admet-733	192	13	should	should	AUX
admet-733	192	14	have	have	VERB
admet-733	192	15	a	a	DET
admet-733	192	16	heavy	heavy	ADJ
admet-733	192	17	atom	atom	NOUN
admet-733	192	18	count	count	NOUN
admet-733	192	19	of	of	ADP
admet-733	192	20	less	less	ADJ
admet-733	192	21	than	than	ADP
admet-733	192	22	20	20	NUM
admet-733	192	23	,	,	PUNCT
admet-733	192	24	have	have	VERB
admet-733	192	25	molecular	molecular	ADJ
admet-733	192	26	weight	weight	NOUN
admet-733	192	27	less	less	ADJ
admet-733	192	28	than	than	ADP
admet-733	192	29	275	275	NUM
admet-733	192	30	,	,	PUNCT
admet-733	192	31	a	a	DET
admet-733	192	32	calculated	calculate	VERB
admet-733	192	33	log	log	NOUN
admet-733	192	34	p	p	NOUN
admet-733	192	35	of	of	ADP
admet-733	192	36	less	less	ADJ
admet-733	192	37	than	than	ADP
admet-733	192	38	3	3	NUM
admet-733	192	39	and	and	CCONJ
admet-733	192	40	have	have	VERB
admet-733	192	41	a	a	DET
admet-733	192	42	predicted	predict	VERB
admet-733	192	43	aqueous	aqueous	ADJ
admet-733	192	44	solubility	solubility	NOUN
admet-733	192	45	of	of	ADP
admet-733	192	46	greater	great	ADJ
admet-733	192	47	than	than	ADP
admet-733	192	48	100	100	NUM
admet-733	192	49	µm	µm	NOUN
admet-733	192	50	.	.	PUNCT
admet-733	193	1	additionally	additionally	ADV
admet-733	193	2	,	,	PUNCT
admet-733	193	3	the	the	DET
admet-733	193	4	soluble	soluble	ADJ
admet-733	193	5	set	set	NOUN
admet-733	193	6	was	be	AUX
admet-733	193	7	designed	design	VERB
admet-733	193	8	for	for	ADP
admet-733	193	9	spr	spr	ADJ
admet-733	193	10	screening	screening	NOUN
admet-733	193	11	,	,	PUNCT
admet-733	193	12	so	so	ADV
admet-733	193	13	contained	contain	VERB
admet-733	193	14	compounds	compound	NOUN
admet-733	193	15	that	that	PRON
admet-733	193	16	were	be	AUX
admet-733	193	17	larger	large	ADJ
admet-733	193	18	(	(	PUNCT
admet-733	193	19	potentially	potentially	ADV
admet-733	193	20	important	important	ADJ
admet-733	193	21	for	for	ADP
admet-733	193	22	the	the	DET
admet-733	193	23	indirect	indirect	ADJ
admet-733	193	24	mass	mass	NOUN
admet-733	193	25	detection	detection	NOUN
admet-733	193	26	)	)	PUNCT
admet-733	193	27	,	,	PUNCT
admet-733	193	28	more	more	ADV
admet-733	193	29	complex	complex	ADJ
admet-733	193	30	,	,	PUNCT
admet-733	193	31	and	and	CCONJ
admet-733	193	32	had	have	AUX
admet-733	193	33	previously	previously	ADV
admet-733	193	34	been	be	AUX
admet-733	193	35	checked	check	VERB
admet-733	193	36	for	for	ADP
admet-733	193	37	issues	issue	NOUN
admet-733	193	38	of	of	ADP
admet-733	193	39	aggregation	aggregation	NOUN
admet-733	193	40	/	/	SYM
admet-733	193	41	interaction	interaction	NOUN
admet-733	193	42	with	with	ADP
admet-733	193	43	the	the	DET
admet-733	193	44	dextran	dextran	NOUN
admet-733	193	45	matrix	matrix	NOUN
admet-733	193	46	by	by	ADP
admet-733	193	47	‘	'	PUNCT
admet-733	193	48	cleanscreening	cleanscreening	NOUN
admet-733	193	49	’	'	PUNCT
admet-733	194	1	[	[	X
admet-733	194	2	35	35	NUM
admet-733	194	3	]	]	PUNCT
admet-733	194	4	.	.	PUNCT
admet-733	195	1	the	the	DET
admet-733	195	2	overlapping	overlap	VERB
admet-733	195	3	768	768	NUM
admet-733	195	4	compounds	compound	NOUN
admet-733	195	5	formed	form	VERB
admet-733	195	6	a	a	DET
admet-733	195	7	‘	'	PUNCT
admet-733	195	8	ligandability	ligandability	NOUN
admet-733	195	9	’	'	PUNCT
admet-733	195	10	set	set	NOUN
admet-733	195	11	that	that	PRON
admet-733	195	12	were	be	AUX
admet-733	195	13	of	of	ADP
admet-733	195	14	intermediate	intermediate	ADJ
admet-733	195	15	complexity	complexity	NOUN
admet-733	195	16	,	,	PUNCT
admet-733	195	17	soluble	soluble	ADJ
admet-733	195	18	and	and	CCONJ
admet-733	195	19	’	'	PUNCT
admet-733	195	20	clean	clean	ADJ
admet-733	195	21	’	'	PUNCT
admet-733	195	22	and	and	CCONJ
admet-733	195	23	could	could	AUX
admet-733	195	24	be	be	AUX
admet-733	195	25	used	use	VERB
admet-733	195	26	to	to	PART
admet-733	195	27	assess	assess	VERB
admet-733	195	28	ligandability	ligandability	NOUN
admet-733	195	29	by	by	ADP
admet-733	195	30	any	any	DET
admet-733	195	31	appropriate	appropriate	ADJ
admet-733	195	32	biophysical	biophysical	ADJ
admet-733	195	33	method	method	NOUN
admet-733	195	34	,	,	PUNCT
admet-733	195	35	figure	figure	NOUN
admet-733	195	36	4	4	NUM
admet-733	195	37	.	.	PUNCT
admet-733	196	1	using	use	VERB
admet-733	196	2	these	these	DET
admet-733	196	3	sets	set	NOUN
admet-733	196	4	of	of	ADP
admet-733	196	5	compounds	compound	NOUN
admet-733	196	6	enables	enable	VERB
admet-733	196	7	an	an	DET
admet-733	196	8	efficient	efficient	ADJ
admet-733	196	9	workflow	workflow	NOUN
admet-733	196	10	for	for	ADP
admet-733	196	11	both	both	PRON
admet-733	196	12	initial	initial	ADJ
admet-733	196	13	ligandability	ligandability	NOUN
admet-733	196	14	assessment	assessment	NOUN
admet-733	196	15	and	and	CCONJ
admet-733	196	16	primary	primary	ADJ
admet-733	196	17	fragment	fragment	NOUN
admet-733	196	18	screening	screening	NOUN
admet-733	196	19	by	by	ADP
admet-733	196	20	nmr	nmr	NOUN
admet-733	196	21	and	and	CCONJ
admet-733	196	22	spr	spr	NOUN
admet-733	196	23	.	.	PROPN
admet-733	196	24	admet	admet	PROPN
admet-733	196	25	&	&	CCONJ
admet-733	196	26	dmpk	dmpk	PROPN
admet-733	196	27	7(4	7(4	NUM
admet-733	196	28	)	)	PUNCT
admet-733	196	29	(	(	PUNCT
admet-733	196	30	2019	2019	NUM
admet-733	196	31	)	)	PUNCT
admet-733	196	32	222	222	NUM
admet-733	196	33	-	-	PUNCT
admet-733	196	34	241	241	NUM
admet-733	196	35	biophysical	biophysical	ADJ
admet-733	196	36	methods	method	NOUN
admet-733	196	37	in	in	ADP
admet-733	196	38	early	early	ADJ
admet-733	196	39	drug	drug	NOUN
admet-733	196	40	discovery	discovery	NOUN
admet-733	196	41	doi	doi	PROPN
admet-733	196	42	:	:	PUNCT
admet-733	196	43	10.5599	10.5599	NUM
admet-733	196	44	/	/	SYM
admet-733	196	45	admet.733	admet.733	ADJ
admet-733	196	46	233	233	NUM
admet-733	196	47	figure	figure	NOUN
admet-733	196	48	4	4	NUM
admet-733	196	49	.	.	PUNCT
admet-733	196	50	description	description	NOUN
admet-733	196	51	of	of	ADP
admet-733	196	52	the	the	DET
admet-733	196	53	astrazeneca	astrazeneca	PROPN
admet-733	196	54	core	core	PROPN
admet-733	196	55	fragment	fragment	NOUN
admet-733	196	56	library	library	NOUN
admet-733	196	57	.	.	PUNCT
admet-733	197	1	hit	hit	VERB
admet-733	197	2	confirmation	confirmation	NOUN
admet-733	197	3	to	to	PART
admet-733	197	4	ensure	ensure	VERB
admet-733	197	5	that	that	SCONJ
admet-733	197	6	hits	hit	NOUN
admet-733	197	7	identified	identify	VERB
admet-733	197	8	via	via	ADP
admet-733	197	9	hts	hts	PROPN
admet-733	197	10	are	be	AUX
admet-733	197	11	valid	valid	ADJ
admet-733	197	12	before	before	ADP
admet-733	197	13	subsequent	subsequent	ADJ
admet-733	197	14	time	time	NOUN
admet-733	197	15	and	and	CCONJ
admet-733	197	16	resource	resource	NOUN
admet-733	197	17	are	be	AUX
admet-733	197	18	invested	invest	VERB
admet-733	197	19	in	in	ADP
admet-733	197	20	optimisation	optimisation	NOUN
admet-733	197	21	activities	activity	NOUN
admet-733	197	22	several	several	ADJ
admet-733	197	23	steps	step	NOUN
admet-733	197	24	are	be	AUX
admet-733	197	25	applied	apply	VERB
admet-733	197	26	in	in	ADP
admet-733	197	27	the	the	DET
admet-733	197	28	workflow	workflow	NOUN
admet-733	197	29	shown	show	VERB
admet-733	197	30	in	in	ADP
admet-733	197	31	figure	figure	NOUN
admet-733	197	32	5	5	NUM
admet-733	197	33	.	.	PUNCT
admet-733	198	1	this	this	PRON
admet-733	198	2	involves	involve	VERB
admet-733	198	3	re	re	ADJ
admet-733	198	4	-	-	NOUN
admet-733	198	5	testing	test	VERB
admet-733	198	6	actives	active	NOUN
admet-733	198	7	in	in	ADP
admet-733	198	8	the	the	DET
admet-733	198	9	same	same	ADJ
admet-733	198	10	assay	assay	NOUN
admet-733	198	11	format	format	NOUN
admet-733	198	12	as	as	SCONJ
admet-733	198	13	the	the	DET
admet-733	198	14	primary	primary	ADJ
admet-733	198	15	screen	screen	NOUN
admet-733	198	16	to	to	PART
admet-733	198	17	confirm	confirm	VERB
admet-733	198	18	that	that	SCONJ
admet-733	198	19	the	the	DET
admet-733	198	20	activity	activity	NOUN
admet-733	198	21	is	be	AUX
admet-733	198	22	reproducible	reproducible	ADJ
admet-733	198	23	.	.	PUNCT
admet-733	199	1	concentration	concentration	NOUN
admet-733	199	2	response	response	NOUN
admet-733	199	3	assays	assay	NOUN
admet-733	199	4	are	be	AUX
admet-733	199	5	then	then	ADV
admet-733	199	6	employed	employ	VERB
admet-733	199	7	to	to	PART
admet-733	199	8	measure	measure	VERB
admet-733	199	9	the	the	DET
admet-733	199	10	concentration	concentration	NOUN
admet-733	199	11	of	of	ADP
admet-733	199	12	test	test	NOUN
admet-733	199	13	compound	compound	NOUN
admet-733	199	14	that	that	PRON
admet-733	199	15	brings	bring	VERB
admet-733	199	16	about	about	ADV
admet-733	199	17	50	50	NUM
admet-733	199	18	%	%	NOUN
admet-733	199	19	of	of	ADP
admet-733	199	20	the	the	DET
admet-733	199	21	maximal	maximal	ADJ
admet-733	199	22	effect	effect	NOUN
admet-733	199	23	(	(	PUNCT
admet-733	199	24	ec50	ec50	PROPN
admet-733	199	25	)	)	PUNCT
admet-733	199	26	.	.	PUNCT
admet-733	200	1	a	a	DET
admet-733	200	2	range	range	NOUN
admet-733	200	3	of	of	ADP
admet-733	200	4	counter	counter	NOUN
admet-733	200	5	screens	screen	NOUN
admet-733	200	6	may	may	AUX
admet-733	200	7	be	be	AUX
admet-733	200	8	used	use	VERB
admet-733	200	9	to	to	PART
admet-733	200	10	determine	determine	VERB
admet-733	200	11	whether	whether	SCONJ
admet-733	200	12	potential	potential	ADJ
admet-733	200	13	hit	hit	VERB
admet-733	200	14	compounds	compound	NOUN
admet-733	200	15	demonstrate	demonstrate	VERB
admet-733	200	16	artefactual	artefactual	ADJ
admet-733	200	17	behaviour	behaviour	NOUN
admet-733	200	18	,	,	PUNCT
admet-733	200	19	if	if	SCONJ
admet-733	200	20	they	they	PRON
admet-733	200	21	possess	possess	VERB
admet-733	200	22	unwanted	unwanted	ADJ
admet-733	200	23	mechanisms	mechanism	NOUN
admet-733	200	24	of	of	ADP
admet-733	200	25	action	action	NOUN
admet-733	200	26	or	or	CCONJ
admet-733	200	27	whether	whether	SCONJ
admet-733	200	28	they	they	PRON
admet-733	200	29	also	also	ADV
admet-733	200	30	affect	affect	VERB
admet-733	200	31	a	a	DET
admet-733	200	32	number	number	NOUN
admet-733	200	33	of	of	ADP
admet-733	200	34	related	related	ADJ
admet-733	200	35	targets	target	NOUN
admet-733	200	36	whose	whose	DET
admet-733	200	37	modulation	modulation	NOUN
admet-733	200	38	should	should	AUX
admet-733	200	39	be	be	AUX
admet-733	200	40	avoided	avoid	VERB
admet-733	200	41	for	for	ADP
admet-733	200	42	selectivity	selectivity	NOUN
admet-733	200	43	reasons	reason	NOUN
admet-733	200	44	.	.	PUNCT
admet-733	201	1	typically	typically	ADV
admet-733	201	2	,	,	PUNCT
admet-733	201	3	compounds	compound	NOUN
admet-733	201	4	are	be	AUX
admet-733	201	5	then	then	ADV
admet-733	201	6	grouped	group	VERB
admet-733	201	7	into	into	ADP
admet-733	201	8	clusters	cluster	NOUN
admet-733	201	9	,	,	PUNCT
admet-733	201	10	representing	represent	VERB
admet-733	201	11	the	the	DET
admet-733	201	12	active	active	ADJ
admet-733	201	13	compounds	compound	NOUN
admet-733	201	14	from	from	ADP
admet-733	201	15	each	each	DET
admet-733	201	16	interesting	interesting	ADJ
admet-733	201	17	chemical	chemical	NOUN
admet-733	201	18	series	series	NOUN
admet-733	201	19	.	.	PUNCT
admet-733	202	1	this	this	PRON
admet-733	202	2	allows	allow	VERB
admet-733	202	3	a	a	DET
admet-733	202	4	small	small	ADJ
admet-733	202	5	number	number	NOUN
admet-733	202	6	of	of	ADP
admet-733	202	7	representative	representative	ADJ
admet-733	202	8	compounds	compound	NOUN
admet-733	202	9	from	from	ADP
admet-733	202	10	each	each	DET
admet-733	202	11	cluster	cluster	NOUN
admet-733	202	12	to	to	PART
admet-733	202	13	be	be	AUX
admet-733	202	14	tested	test	VERB
admet-733	202	15	in	in	ADP
admet-733	202	16	a	a	DET
admet-733	202	17	suitable	suitable	ADJ
admet-733	202	18	biophysical	biophysical	ADJ
admet-733	202	19	technique	technique	NOUN
admet-733	202	20	.	.	PUNCT
admet-733	203	1	positioning	position	VERB
admet-733	203	2	biophysical	biophysical	ADJ
admet-733	203	3	testing	testing	NOUN
admet-733	203	4	early	early	ADV
admet-733	203	5	in	in	ADP
admet-733	203	6	this	this	DET
admet-733	203	7	way	way	NOUN
admet-733	203	8	allows	allow	VERB
admet-733	203	9	focus	focus	NOUN
admet-733	203	10	on	on	ADP
admet-733	203	11	those	those	DET
admet-733	203	12	compounds	compound	NOUN
admet-733	203	13	that	that	PRON
admet-733	203	14	are	be	AUX
admet-733	203	15	confirmed	confirm	VERB
admet-733	203	16	by	by	ADP
admet-733	203	17	a	a	DET
admet-733	203	18	biophysical	biophysical	ADJ
admet-733	203	19	method	method	NOUN
admet-733	203	20	and	and	CCONJ
admet-733	203	21	de	de	NOUN
admet-733	203	22	-	-	ADJ
admet-733	203	23	prioritising	prioritise	VERB
admet-733	203	24	those	those	PRON
admet-733	203	25	that	that	PRON
admet-733	203	26	may	may	AUX
admet-733	203	27	likely	likely	ADV
admet-733	203	28	be	be	AUX
admet-733	203	29	false	false	ADJ
admet-733	203	30	positives	positive	NOUN
admet-733	203	31	.	.	PUNCT
admet-733	204	1	in	in	ADP
admet-733	204	2	this	this	DET
admet-733	204	3	context	context	NOUN
admet-733	204	4	,	,	PUNCT
admet-733	204	5	biophysical	biophysical	ADJ
admet-733	204	6	methods	method	NOUN
admet-733	204	7	provide	provide	VERB
admet-733	204	8	a	a	DET
admet-733	204	9	means	means	NOUN
admet-733	204	10	of	of	ADP
admet-733	204	11	selecting	select	VERB
admet-733	204	12	compounds	compound	NOUN
admet-733	204	13	based	base	VERB
admet-733	204	14	on	on	ADP
admet-733	204	15	positive	positive	ADJ
admet-733	204	16	selection	selection	NOUN
admet-733	204	17	criteria	criterion	NOUN
admet-733	204	18	such	such	ADJ
admet-733	204	19	as	as	ADP
admet-733	204	20	target	target	NOUN
admet-733	204	21	engagement	engagement	NOUN
admet-733	204	22	,	,	PUNCT
admet-733	204	23	mode	mode	NOUN
admet-733	204	24	of	of	ADP
admet-733	204	25	action	action	NOUN
admet-733	204	26	,	,	PUNCT
admet-733	204	27	and	and	CCONJ
admet-733	204	28	for	for	ADP
admet-733	204	29	some	some	DET
admet-733	204	30	methods	method	NOUN
admet-733	204	31	even	even	ADV
admet-733	204	32	functional	functional	ADJ
admet-733	204	33	activity	activity	NOUN
admet-733	204	34	(	(	PUNCT
admet-733	204	35	ms	ms	NOUN
admet-733	204	36	,	,	PUNCT
admet-733	204	37	nmr	nmr	NOUN
admet-733	204	38	and	and	CCONJ
admet-733	204	39	even	even	ADV
admet-733	204	40	itc	itc	PROPN
admet-733	204	41	can	can	AUX
admet-733	204	42	for	for	ADP
admet-733	204	43	instance	instance	NOUN
admet-733	204	44	,	,	PUNCT
admet-733	204	45	be	be	AUX
admet-733	204	46	used	use	VERB
admet-733	204	47	to	to	PART
admet-733	204	48	monitor	monitor	VERB
admet-733	204	49	inhibition	inhibition	NOUN
admet-733	204	50	of	of	ADP
admet-733	204	51	substrate	substrate	NOUN
admet-733	204	52	conversion	conversion	NOUN
admet-733	204	53	for	for	ADP
admet-733	204	54	enzymatic	enzymatic	ADJ
admet-733	204	55	reactions	reaction	NOUN
admet-733	204	56	)	)	PUNCT
admet-733	204	57	,	,	PUNCT
admet-733	204	58	rather	rather	ADV
admet-733	204	59	than	than	ADP
admet-733	204	60	the	the	DET
admet-733	204	61	negative	negative	ADJ
admet-733	204	62	criteria	criterion	NOUN
admet-733	204	63	associated	associate	VERB
admet-733	204	64	with	with	ADP
admet-733	204	65	filtering	filter	VERB
admet-733	204	66	compounds	compound	NOUN
admet-733	204	67	for	for	ADP
admet-733	204	68	unwanted	unwanted	ADJ
admet-733	204	69	mechanism	mechanism	NOUN
admet-733	204	70	of	of	ADP
admet-733	204	71	action	action	NOUN
admet-733	204	72	.	.	PUNCT
admet-733	205	1	figure	figure	NOUN
admet-733	205	2	5	5	NUM
admet-733	205	3	.	.	PUNCT
admet-733	206	1	the	the	DET
admet-733	206	2	combination	combination	NOUN
admet-733	206	3	of	of	ADP
admet-733	206	4	approaches	approach	NOUN
admet-733	206	5	that	that	PRON
admet-733	206	6	are	be	AUX
admet-733	206	7	used	use	VERB
admet-733	206	8	to	to	PART
admet-733	206	9	triage	triage	VERB
admet-733	206	10	from	from	ADP
admet-733	206	11	primary	primary	ADJ
admet-733	206	12	screening	screening	NOUN
admet-733	206	13	actives	active	NOUN
admet-733	206	14	to	to	ADP
admet-733	206	15	validated	validate	VERB
admet-733	206	16	hits	hit	NOUN
admet-733	206	17	.	.	PUNCT
admet-733	207	1	holdgate	holdgate	VERB
admet-733	207	2	et	et	PROPN
admet-733	207	3	al	al	PROPN
admet-733	207	4	.	.	PROPN
admet-733	207	5	admet	admet	PROPN
admet-733	207	6	&	&	CCONJ
admet-733	207	7	dmpk	dmpk	PROPN
admet-733	207	8	7(4	7(4	NUM
admet-733	207	9	)	)	PUNCT
admet-733	207	10	(	(	PUNCT
admet-733	207	11	2019	2019	NUM
admet-733	207	12	)	)	PUNCT
admet-733	207	13	222	222	NUM
admet-733	207	14	-	-	SYM
admet-733	207	15	241	241	NUM
admet-733	207	16	234	234	NUM
admet-733	207	17	as	as	ADP
admet-733	207	18	with	with	ADP
admet-733	207	19	other	other	ADJ
admet-733	207	20	application	application	NOUN
admet-733	207	21	areas	area	NOUN
admet-733	207	22	of	of	ADP
admet-733	207	23	biophysical	biophysical	ADJ
admet-733	207	24	methods	method	NOUN
admet-733	207	25	,	,	PUNCT
admet-733	207	26	each	each	PRON
admet-733	207	27	has	have	VERB
admet-733	207	28	its	its	PRON
admet-733	207	29	own	own	ADJ
admet-733	207	30	strengths	strength	NOUN
admet-733	207	31	and	and	CCONJ
admet-733	207	32	weaknesses	weakness	NOUN
admet-733	207	33	in	in	ADP
admet-733	207	34	hit	hit	VERB
admet-733	207	35	confirmation	confirmation	NOUN
admet-733	207	36	and	and	CCONJ
admet-733	207	37	the	the	DET
admet-733	207	38	choice	choice	NOUN
admet-733	207	39	of	of	ADP
admet-733	207	40	method	method	NOUN
admet-733	207	41	will	will	AUX
admet-733	207	42	depend	depend	VERB
admet-733	207	43	upon	upon	SCONJ
admet-733	207	44	the	the	DET
admet-733	207	45	throughput	throughput	NOUN
admet-733	207	46	required	require	VERB
admet-733	207	47	,	,	PUNCT
admet-733	207	48	the	the	DET
admet-733	207	49	amount	amount	NOUN
admet-733	207	50	of	of	ADP
admet-733	207	51	protein	protein	NOUN
admet-733	207	52	available	available	ADJ
admet-733	207	53	,	,	PUNCT
admet-733	207	54	the	the	DET
admet-733	207	55	affinity	affinity	NOUN
admet-733	207	56	range	range	NOUN
admet-733	207	57	expected	expect	VERB
admet-733	207	58	and	and	CCONJ
admet-733	207	59	the	the	DET
admet-733	207	60	information	information	NOUN
admet-733	207	61	content	content	NOUN
admet-733	207	62	desired	desire	VERB
admet-733	207	63	,	,	PUNCT
admet-733	207	64	table	table	NOUN
admet-733	207	65	4	4	NUM
admet-733	207	66	.	.	PUNCT
admet-733	208	1	if	if	SCONJ
admet-733	208	2	possible	possible	ADJ
admet-733	208	3	,	,	PUNCT
admet-733	208	4	the	the	DET
admet-733	208	5	hit	hit	VERB
admet-733	208	6	confirmation	confirmation	NOUN
admet-733	208	7	strategy	strategy	NOUN
admet-733	208	8	may	may	AUX
admet-733	208	9	include	include	VERB
admet-733	208	10	several	several	ADJ
admet-733	208	11	techniques	technique	NOUN
admet-733	208	12	to	to	PART
admet-733	208	13	provide	provide	VERB
admet-733	208	14	increased	increase	VERB
admet-733	208	15	confidence	confidence	NOUN
admet-733	208	16	and	and	CCONJ
admet-733	208	17	deliver	deliver	VERB
admet-733	208	18	a	a	DET
admet-733	208	19	deeper	deep	ADJ
admet-733	208	20	understanding	understanding	NOUN
admet-733	208	21	of	of	ADP
admet-733	208	22	the	the	DET
admet-733	208	23	binding	bind	VERB
admet-733	208	24	interaction	interaction	NOUN
admet-733	208	25	.	.	PUNCT
admet-733	209	1	positioning	position	VERB
admet-733	209	2	one	one	NUM
admet-733	209	3	or	or	CCONJ
admet-733	209	4	more	more	ADJ
admet-733	209	5	biophysical	biophysical	ADJ
admet-733	209	6	methods	method	NOUN
admet-733	209	7	will	will	AUX
admet-733	209	8	depend	depend	VERB
admet-733	209	9	upon	upon	SCONJ
admet-733	209	10	what	what	PRON
admet-733	209	11	is	be	AUX
admet-733	209	12	known	know	VERB
admet-733	209	13	about	about	ADP
admet-733	209	14	the	the	DET
admet-733	209	15	target	target	NOUN
admet-733	209	16	protein	protein	NOUN
admet-733	209	17	,	,	PUNCT
admet-733	209	18	what	what	PRON
admet-733	209	19	is	be	AUX
admet-733	209	20	required	require	VERB
admet-733	209	21	in	in	ADP
admet-733	209	22	terms	term	NOUN
admet-733	209	23	of	of	ADP
admet-733	209	24	setting	set	VERB
admet-733	209	25	up	up	ADP
admet-733	209	26	each	each	DET
admet-733	209	27	biophysical	biophysical	ADJ
admet-733	209	28	method	method	NOUN
admet-733	209	29	and	and	CCONJ
admet-733	209	30	the	the	DET
admet-733	209	31	information	information	NOUN
admet-733	209	32	desired	desire	VERB
admet-733	209	33	.	.	PUNCT
admet-733	210	1	an	an	DET
admet-733	210	2	important	important	ADJ
admet-733	210	3	consideration	consideration	NOUN
admet-733	210	4	is	be	AUX
admet-733	210	5	how	how	SCONJ
admet-733	210	6	biophysics	biophysic	NOUN
admet-733	210	7	might	might	AUX
admet-733	210	8	be	be	AUX
admet-733	210	9	used	use	VERB
admet-733	210	10	in	in	ADP
admet-733	210	11	the	the	DET
admet-733	210	12	confirmation	confirmation	NOUN
admet-733	210	13	of	of	ADP
admet-733	210	14	hits	hit	NOUN
admet-733	210	15	resulting	result	VERB
admet-733	210	16	from	from	ADP
admet-733	210	17	cell	cell	NOUN
admet-733	210	18	-	-	PUNCT
admet-733	210	19	based	base	VERB
admet-733	210	20	screening	screening	NOUN
admet-733	210	21	.	.	PUNCT
admet-733	211	1	of	of	ADP
admet-733	211	2	course	course	ADV
admet-733	211	3	,	,	PUNCT
admet-733	211	4	for	for	ADP
admet-733	211	5	isolated	isolated	ADJ
admet-733	211	6	protein	protein	NOUN
admet-733	211	7	-	-	PUNCT
admet-733	211	8	based	base	VERB
admet-733	211	9	biochemical	biochemical	ADJ
admet-733	211	10	assays	assay	NOUN
admet-733	211	11	,	,	PUNCT
admet-733	211	12	the	the	DET
admet-733	211	13	same	same	ADJ
admet-733	211	14	or	or	CCONJ
admet-733	211	15	similar	similar	ADJ
admet-733	211	16	protein	protein	NOUN
admet-733	211	17	constructs	construct	NOUN
admet-733	211	18	may	may	AUX
admet-733	211	19	be	be	AUX
admet-733	211	20	used	use	VERB
admet-733	211	21	for	for	ADP
admet-733	211	22	the	the	DET
admet-733	211	23	biophysical	biophysical	ADJ
admet-733	211	24	triage	triage	NOUN
admet-733	211	25	step	step	NOUN
admet-733	211	26	,	,	PUNCT
admet-733	211	27	and	and	CCONJ
admet-733	211	28	so	so	ADV
admet-733	211	29	the	the	DET
admet-733	211	30	physiological	physiological	ADJ
admet-733	211	31	relevance	relevance	NOUN
admet-733	211	32	(	(	PUNCT
admet-733	211	33	or	or	CCONJ
admet-733	211	34	lack	lack	NOUN
admet-733	211	35	thereof	thereof	ADV
admet-733	211	36	)	)	PUNCT
admet-733	211	37	of	of	ADP
admet-733	211	38	each	each	PRON
admet-733	211	39	is	be	AUX
admet-733	211	40	at	at	ADP
admet-733	211	41	least	least	ADJ
admet-733	211	42	consistent	consistent	ADJ
admet-733	211	43	.	.	PUNCT
admet-733	212	1	this	this	PRON
admet-733	212	2	is	be	AUX
admet-733	212	3	different	different	ADJ
admet-733	212	4	for	for	ADP
admet-733	212	5	the	the	DET
admet-733	212	6	case	case	NOUN
admet-733	212	7	of	of	ADP
admet-733	212	8	cell	cell	NOUN
admet-733	212	9	screens	screen	NOUN
admet-733	212	10	,	,	PUNCT
admet-733	212	11	where	where	SCONJ
admet-733	212	12	the	the	DET
admet-733	212	13	biophysical	biophysical	ADJ
admet-733	212	14	approach	approach	NOUN
admet-733	212	15	may	may	AUX
admet-733	212	16	be	be	AUX
admet-733	212	17	considered	consider	VERB
admet-733	212	18	less	less	ADV
admet-733	212	19	physiologically	physiologically	ADV
admet-733	212	20	relevant	relevant	ADJ
admet-733	212	21	than	than	SCONJ
admet-733	212	22	the	the	DET
admet-733	212	23	cell	cell	NOUN
admet-733	212	24	assay	assay	VERB
admet-733	212	25	.	.	PUNCT
admet-733	213	1	biophysical	biophysical	ADJ
admet-733	213	2	methods	method	NOUN
admet-733	213	3	still	still	ADV
admet-733	213	4	have	have	VERB
admet-733	213	5	value	value	NOUN
admet-733	213	6	in	in	ADP
admet-733	213	7	confirming	confirm	VERB
admet-733	213	8	binding	bind	VERB
admet-733	213	9	and	and	CCONJ
admet-733	213	10	providing	provide	VERB
admet-733	213	11	additional	additional	ADJ
admet-733	213	12	information	information	NOUN
admet-733	213	13	,	,	PUNCT
admet-733	213	14	but	but	CCONJ
admet-733	213	15	extra	extra	ADJ
admet-733	213	16	caution	caution	NOUN
admet-733	213	17	needs	need	VERB
admet-733	213	18	to	to	PART
admet-733	213	19	be	be	AUX
admet-733	213	20	applied	apply	VERB
admet-733	213	21	in	in	ADP
admet-733	213	22	comparing	compare	VERB
admet-733	213	23	the	the	DET
admet-733	213	24	results	result	NOUN
admet-733	213	25	and	and	CCONJ
admet-733	213	26	in	in	ADP
admet-733	213	27	making	make	VERB
admet-733	213	28	decisions	decision	NOUN
admet-733	213	29	about	about	ADP
admet-733	213	30	fate	fate	NOUN
admet-733	213	31	of	of	ADP
admet-733	213	32	compounds	compound	NOUN
admet-733	213	33	based	base	VERB
admet-733	213	34	on	on	ADP
admet-733	213	35	similarities	similarity	NOUN
admet-733	213	36	or	or	CCONJ
admet-733	213	37	differences	difference	NOUN
admet-733	213	38	.	.	PUNCT
admet-733	214	1	in	in	ADP
admet-733	214	2	this	this	DET
admet-733	214	3	situation	situation	NOUN
admet-733	214	4	,	,	PUNCT
admet-733	214	5	there	there	PRON
admet-733	214	6	is	be	VERB
admet-733	214	7	additional	additional	ADJ
admet-733	214	8	value	value	NOUN
admet-733	214	9	in	in	ADP
admet-733	214	10	the	the	DET
admet-733	214	11	use	use	NOUN
admet-733	214	12	of	of	ADP
admet-733	214	13	tool	tool	NOUN
admet-733	214	14	compounds	compound	NOUN
admet-733	214	15	which	which	PRON
admet-733	214	16	may	may	AUX
admet-733	214	17	have	have	VERB
admet-733	214	18	similar	similar	ADJ
admet-733	214	19	modes	mode	NOUN
admet-733	214	20	of	of	ADP
admet-733	214	21	action	action	NOUN
admet-733	214	22	to	to	ADP
admet-733	214	23	hts	hts	PROPN
admet-733	214	24	hits	hit	NOUN
admet-733	214	25	.	.	PUNCT
admet-733	215	1	confidence	confidence	NOUN
admet-733	215	2	can	can	AUX
admet-733	215	3	be	be	AUX
admet-733	215	4	gained	gain	VERB
admet-733	215	5	for	for	ADP
admet-733	215	6	those	those	DET
admet-733	215	7	hts	ht	NOUN
admet-733	215	8	hits	hit	NOUN
admet-733	215	9	that	that	PRON
admet-733	215	10	show	show	VERB
admet-733	215	11	similar	similar	ADJ
admet-733	215	12	behaviour	behaviour	NOUN
admet-733	215	13	to	to	ADP
admet-733	215	14	the	the	DET
admet-733	215	15	tool	tool	NOUN
admet-733	215	16	compounds	compound	VERB
admet-733	215	17	during	during	ADP
admet-733	215	18	the	the	DET
admet-733	215	19	biophysics	biophysic	NOUN
admet-733	215	20	confirmation	confirmation	NOUN
admet-733	215	21	stage	stage	NOUN
admet-733	215	22	.	.	PUNCT
admet-733	216	1	it	it	PRON
admet-733	216	2	may	may	AUX
admet-733	216	3	also	also	ADV
admet-733	216	4	be	be	AUX
admet-733	216	5	prudent	prudent	ADJ
admet-733	216	6	to	to	PART
admet-733	216	7	explore	explore	VERB
admet-733	216	8	additional	additional	ADJ
admet-733	216	9	(	(	PUNCT
admet-733	216	10	biophysical	biophysical	ADJ
admet-733	216	11	)	)	PUNCT
admet-733	216	12	methods	method	NOUN
admet-733	216	13	that	that	PRON
admet-733	216	14	allow	allow	VERB
admet-733	216	15	interrogation	interrogation	NOUN
admet-733	216	16	of	of	ADP
admet-733	216	17	target	target	NOUN
admet-733	216	18	engagement	engagement	NOUN
admet-733	216	19	in	in	ADP
admet-733	216	20	cells	cell	NOUN
admet-733	216	21	such	such	ADJ
admet-733	216	22	as	as	ADP
admet-733	216	23	cetsa	cetsa	NOUN
admet-733	216	24	(	(	PUNCT
admet-733	216	25	cellular	cellular	ADJ
admet-733	216	26	thermal	thermal	ADJ
admet-733	216	27	shift	shift	NOUN
admet-733	216	28	assay	assay	NOUN
admet-733	216	29	)	)	PUNCT
admet-733	217	1	[	[	X
admet-733	217	2	36	36	NUM
admet-733	217	3	]	]	PUNCT
admet-733	217	4	.	.	PUNCT
admet-733	218	1	table	table	NOUN
admet-733	218	2	4	4	NUM
admet-733	218	3	.	.	PUNCT
admet-733	218	4	comparison	comparison	NOUN
admet-733	218	5	of	of	ADP
admet-733	218	6	the	the	DET
admet-733	218	7	some	some	PRON
admet-733	218	8	of	of	ADP
admet-733	218	9	the	the	DET
admet-733	218	10	most	most	ADV
admet-733	218	11	common	common	ADJ
admet-733	218	12	methods	method	NOUN
admet-733	218	13	used	use	VERB
admet-733	218	14	for	for	ADP
admet-733	218	15	hit	hit	VERB
admet-733	218	16	confirmation	confirmation	NOUN
admet-733	218	17	.	.	PUNCT
admet-733	219	1	technique	technique	NOUN
admet-733	219	2	specific	specific	ADJ
admet-733	219	3	requirements	requirement	NOUN
admet-733	219	4	protein	protein	NOUN
admet-733	219	5	consumption	consumption	NOUN
admet-733	219	6	throughput	throughput	NOUN
admet-733	219	7	dynamic	dynamic	ADJ
admet-733	219	8	range	range	NOUN
admet-733	219	9	information	information	NOUN
admet-733	219	10	content	content	NOUN
admet-733	219	11	nmr	nmr	NOUN
admet-733	219	12	15	15	NUM
admet-733	219	13	n	n	NOUN
admet-733	219	14	labelling	label	VERB
admet-733	219	15	for	for	ADP
admet-733	219	16	2d	2d	NUM
admet-733	219	17	protein	protein	NOUN
admet-733	219	18	observed	observe	VERB
admet-733	219	19	nmr	nmr	NOUN
admet-733	219	20	high	high	ADJ
admet-733	219	21	medium	medium	ADJ
admet-733	219	22	mm	mm	PROPN
admet-733	219	23	µm	µm	ADP
admet-733	219	24	high	high	ADJ
admet-733	219	25	(	(	PUNCT
admet-733	219	26	binding	bind	VERB
admet-733	219	27	site	site	NOUN
admet-733	219	28	)	)	PUNCT
admet-733	219	29	spr	spr	PROPN
admet-733	219	30	suitable	suitable	ADJ
admet-733	219	31	immobilisation	immobilisation	PROPN
admet-733	219	32	low	low	PROPN
admet-733	219	33	high	high	ADJ
admet-733	219	34	mm	mm	NOUN
admet-733	219	35	pm	pm	NOUN
admet-733	219	36	high	high	ADJ
admet-733	219	37	(	(	PUNCT
admet-733	219	38	kinetics	kinetic	NOUN
admet-733	219	39	)	)	PUNCT
admet-733	219	40	itc	itc	NOUN
admet-733	219	41	protein	protein	NOUN
admet-733	219	42	and	and	CCONJ
admet-733	219	43	ligand	ligand	NOUN
admet-733	219	44	in	in	ADP
admet-733	219	45	identical	identical	ADJ
admet-733	219	46	buffer	buffer	NOUN
admet-733	219	47	high	high	ADJ
admet-733	219	48	low	low	ADJ
admet-733	219	49	mm	mm	INTJ
admet-733	219	50	nm	nm	ADV
admet-733	219	51	high	high	ADJ
admet-733	219	52	(	(	PUNCT
admet-733	219	53	thermodynamics	thermodynamic	NOUN
admet-733	219	54	)	)	PUNCT
admet-733	219	55	mst	mst	PROPN
admet-733	219	56	fluorescent	fluorescent	ADJ
admet-733	219	57	labelling	labelling	NOUN
admet-733	219	58	of	of	ADP
admet-733	219	59	one	one	NUM
admet-733	219	60	partner	partner	NOUN
admet-733	219	61	low	low	ADJ
admet-733	219	62	medium	medium	ADJ
admet-733	219	63	mm	mm	NOUN
admet-733	219	64	pm	pm	NOUN
admet-733	219	65	medium	medium	ADJ
admet-733	219	66	(	(	PUNCT
admet-733	219	67	affinity	affinity	NOUN
admet-733	219	68	)	)	PUNCT
admet-733	219	69	mechanistic	mechanistic	ADJ
admet-733	219	70	characterisation	characterisation	NOUN
admet-733	219	71	biophysical	biophysical	ADJ
admet-733	219	72	methods	method	NOUN
admet-733	219	73	are	be	AUX
admet-733	219	74	extremely	extremely	ADV
admet-733	219	75	valuable	valuable	ADJ
admet-733	219	76	in	in	ADP
admet-733	219	77	helping	help	VERB
admet-733	219	78	to	to	PART
admet-733	219	79	carry	carry	VERB
admet-733	219	80	out	out	ADP
admet-733	219	81	in	in	ADP
admet-733	219	82	depth	depth	NOUN
admet-733	219	83	characterisation	characterisation	NOUN
admet-733	219	84	of	of	ADP
admet-733	219	85	proteinligand	proteinligand	ADJ
admet-733	219	86	binding	bind	VERB
admet-733	219	87	interactions	interaction	NOUN
admet-733	219	88	.	.	PUNCT
admet-733	220	1	they	they	PRON
admet-733	220	2	often	often	ADV
admet-733	220	3	provide	provide	VERB
admet-733	220	4	a	a	DET
admet-733	220	5	simpler	simple	ADJ
admet-733	220	6	way	way	NOUN
admet-733	220	7	of	of	ADP
admet-733	220	8	complementing	complement	VERB
admet-733	220	9	biochemical	biochemical	ADJ
admet-733	220	10	approaches	approach	NOUN
admet-733	220	11	in	in	ADP
admet-733	220	12	providing	provide	VERB
admet-733	220	13	kinetic	kinetic	NOUN
admet-733	220	14	,	,	PUNCT
admet-733	220	15	thermodynamic	thermodynamic	ADJ
admet-733	220	16	and	and	CCONJ
admet-733	220	17	mode	mode	NOUN
admet-733	220	18	of	of	ADP
admet-733	220	19	action	action	NOUN
admet-733	220	20	information	information	NOUN
admet-733	220	21	.	.	PUNCT
admet-733	221	1	for	for	ADP
admet-733	221	2	example	example	NOUN
admet-733	221	3	,	,	PUNCT
admet-733	221	4	kinetic	kinetic	ADJ
admet-733	221	5	binding	bind	VERB
admet-733	221	6	information	information	NOUN
admet-733	221	7	can	can	AUX
admet-733	221	8	be	be	AUX
admet-733	221	9	obtained	obtain	VERB
admet-733	221	10	directly	directly	ADV
admet-733	221	11	using	use	VERB
admet-733	221	12	spr	spr	NOUN
admet-733	221	13	,	,	PUNCT
admet-733	221	14	whereas	whereas	SCONJ
admet-733	221	15	traditional	traditional	ADJ
admet-733	221	16	enzyme	enzyme	NOUN
admet-733	221	17	kinetics	kinetic	NOUN
admet-733	221	18	experiments	experiment	NOUN
admet-733	221	19	are	be	AUX
admet-733	221	20	required	require	VERB
admet-733	221	21	to	to	PART
admet-733	221	22	access	access	NOUN
admet-733	221	23	rate	rate	NOUN
admet-733	221	24	constants	constant	NOUN
admet-733	221	25	for	for	ADP
admet-733	221	26	slow	slow	ADV
admet-733	221	27	-	-	PUNCT
admet-733	221	28	binding	bind	VERB
admet-733	221	29	interactions	interaction	NOUN
admet-733	221	30	.	.	PUNCT
admet-733	222	1	this	this	PRON
admet-733	222	2	often	often	ADV
admet-733	222	3	entails	entail	VERB
admet-733	222	4	establishing	establish	VERB
admet-733	222	5	time	time	NOUN
admet-733	222	6	-	-	PUNCT
admet-733	222	7	courses	course	NOUN
admet-733	222	8	under	under	ADP
admet-733	222	9	suitable	suitable	ADJ
admet-733	222	10	concentrations	concentration	NOUN
admet-733	222	11	of	of	ADP
admet-733	222	12	substrate(s	substrate(s	NOUN
admet-733	222	13	)	)	PUNCT
admet-733	222	14	for	for	ADP
admet-733	222	15	which	which	PRON
admet-733	222	16	the	the	DET
admet-733	222	17	control	control	NOUN
admet-733	222	18	is	be	AUX
admet-733	222	19	linear	linear	ADJ
admet-733	222	20	and	and	CCONJ
admet-733	222	21	then	then	ADV
admet-733	222	22	observing	observe	VERB
admet-733	222	23	the	the	DET
admet-733	222	24	slow	slow	ADJ
admet-733	222	25	decrease	decrease	NOUN
admet-733	222	26	in	in	ADP
admet-733	222	27	enzymatic	enzymatic	ADJ
admet-733	222	28	rate	rate	NOUN
admet-733	222	29	as	as	SCONJ
admet-733	222	30	the	the	DET
admet-733	222	31	test	test	NOUN
admet-733	222	32	compound	compound	NOUN
admet-733	222	33	equilibrates	equilibrate	VERB
admet-733	222	34	with	with	ADP
admet-733	222	35	the	the	DET
admet-733	222	36	target	target	NOUN
admet-733	222	37	protein	protein	NOUN
admet-733	222	38	.	.	PUNCT
admet-733	223	1	these	these	DET
admet-733	223	2	types	type	NOUN
admet-733	223	3	of	of	ADP
admet-733	223	4	experiments	experiment	NOUN
admet-733	223	5	are	be	AUX
admet-733	223	6	time	time	NOUN
admet-733	223	7	-	-	PUNCT
admet-733	223	8	consuming	consume	VERB
admet-733	223	9	and	and	CCONJ
admet-733	223	10	often	often	ADV
admet-733	223	11	can	can	AUX
admet-733	223	12	be	be	AUX
admet-733	223	13	difficult	difficult	ADJ
admet-733	223	14	to	to	PART
admet-733	223	15	analyse	analyse	VERB
admet-733	223	16	to	to	PART
admet-733	223	17	extract	extract	VERB
admet-733	223	18	the	the	DET
admet-733	223	19	relevant	relevant	ADJ
admet-733	223	20	rate	rate	NOUN
admet-733	223	21	constants	constant	NOUN
admet-733	223	22	controlling	control	VERB
admet-733	223	23	ligand	ligand	NOUN
admet-733	223	24	binding	binding	NOUN
admet-733	223	25	.	.	PUNCT
admet-733	224	1	a	a	DET
admet-733	224	2	further	further	ADJ
admet-733	224	3	example	example	NOUN
admet-733	224	4	is	be	AUX
admet-733	224	5	discerning	discern	VERB
admet-733	224	6	order	order	NOUN
admet-733	224	7	of	of	ADP
admet-733	224	8	addition	addition	NOUN
admet-733	224	9	of	of	ADP
admet-733	224	10	substrates	substrate	NOUN
admet-733	224	11	to	to	ADP
admet-733	224	12	the	the	DET
admet-733	224	13	enzyme	enzyme	NOUN
admet-733	224	14	in	in	ADP
admet-733	224	15	the	the	DET
admet-733	224	16	reaction	reaction	NOUN
admet-733	224	17	mechanism	mechanism	NOUN
admet-733	224	18	.	.	PUNCT
admet-733	225	1	this	this	PRON
admet-733	225	2	can	can	AUX
admet-733	225	3	be	be	AUX
admet-733	225	4	assessed	assess	VERB
admet-733	225	5	using	use	VERB
admet-733	225	6	traditional	traditional	ADJ
admet-733	225	7	enzyme	enzyme	NOUN
admet-733	225	8	kinetic	kinetic	ADJ
admet-733	225	9	experiments	experiment	NOUN
admet-733	225	10	where	where	SCONJ
admet-733	225	11	the	the	DET
admet-733	225	12	rate	rate	NOUN
admet-733	225	13	is	be	AUX
admet-733	225	14	measured	measure	VERB
admet-733	225	15	whilst	whilst	SCONJ
admet-733	225	16	varying	vary	VERB
admet-733	225	17	one	one	NUM
admet-733	225	18	substrate	substrate	NOUN
admet-733	225	19	concentration	concentration	NOUN
admet-733	225	20	in	in	ADP
admet-733	225	21	the	the	DET
admet-733	225	22	presence	presence	NOUN
admet-733	225	23	of	of	ADP
admet-733	225	24	a	a	DET
admet-733	225	25	fixed	fix	VERB
admet-733	225	26	concentration	concentration	NOUN
admet-733	225	27	of	of	ADP
admet-733	225	28	the	the	DET
admet-733	225	29	other	other	ADJ
admet-733	225	30	substrate	substrate	NOUN
admet-733	225	31	.	.	PUNCT
admet-733	226	1	this	this	PRON
admet-733	226	2	can	can	AUX
admet-733	226	3	also	also	ADV
admet-733	226	4	be	be	AUX
admet-733	226	5	extended	extend	VERB
admet-733	226	6	to	to	ADP
admet-733	226	7	test	test	NOUN
admet-733	226	8	compounds	compound	NOUN
admet-733	226	9	.	.	PUNCT
admet-733	227	1	however	however	ADV
admet-733	227	2	,	,	PUNCT
admet-733	227	3	it	it	PRON
admet-733	227	4	can	can	AUX
admet-733	227	5	be	be	AUX
admet-733	227	6	complemented	complement	VERB
admet-733	227	7	relatively	relatively	ADV
admet-733	227	8	straightforwardly	straightforwardly	ADV
admet-733	227	9	by	by	ADP
admet-733	227	10	using	use	VERB
admet-733	227	11	itc	itc	PROPN
admet-733	227	12	to	to	PART
admet-733	227	13	determine	determine	VERB
admet-733	227	14	whether	whether	SCONJ
admet-733	227	15	the	the	DET
admet-733	227	16	presence	presence	NOUN
admet-733	227	17	of	of	ADP
admet-733	227	18	one	one	NUM
admet-733	227	19	ligand	ligand	NOUN
admet-733	227	20	(	(	PUNCT
admet-733	227	21	for	for	ADP
admet-733	227	22	example	example	NOUN
admet-733	227	23	substrate	substrate	NOUN
admet-733	227	24	)	)	PUNCT
admet-733	227	25	is	be	AUX
admet-733	227	26	required	require	VERB
admet-733	227	27	or	or	CCONJ
admet-733	227	28	competes	compete	VERB
admet-733	227	29	with	with	ADP
admet-733	227	30	binding	bind	VERB
admet-733	227	31	of	of	ADP
admet-733	227	32	another	another	PRON
admet-733	227	33	(	(	PUNCT
admet-733	227	34	a	a	DET
admet-733	227	35	second	second	ADJ
admet-733	227	36	substrate	substrate	NOUN
admet-733	227	37	,	,	PUNCT
admet-733	227	38	or	or	CCONJ
admet-733	227	39	analogue	analogue	NOUN
admet-733	227	40	,	,	PUNCT
admet-733	227	41	or	or	CCONJ
admet-733	227	42	a	a	DET
admet-733	227	43	test	test	NOUN
admet-733	227	44	compound	compound	NOUN
admet-733	227	45	)	)	PUNCT
admet-733	227	46	.	.	PUNCT
admet-733	228	1	admet	admet	PROPN
admet-733	228	2	&	&	CCONJ
admet-733	228	3	dmpk	dmpk	PROPN
admet-733	228	4	7(4	7(4	NUM
admet-733	228	5	)	)	PUNCT
admet-733	228	6	(	(	PUNCT
admet-733	228	7	2019	2019	NUM
admet-733	228	8	)	)	PUNCT
admet-733	228	9	222	222	NUM
admet-733	228	10	-	-	PUNCT
admet-733	228	11	241	241	NUM
admet-733	228	12	biophysical	biophysical	ADJ
admet-733	228	13	methods	method	NOUN
admet-733	228	14	in	in	ADP
admet-733	228	15	early	early	ADJ
admet-733	228	16	drug	drug	NOUN
admet-733	228	17	discovery	discovery	NOUN
admet-733	228	18	doi	doi	PROPN
admet-733	228	19	:	:	PUNCT
admet-733	228	20	10.5599	10.5599	NUM
admet-733	228	21	/	/	SYM
admet-733	228	22	admet.733	admet.733	ADJ
admet-733	228	23	235	235	NUM
admet-733	228	24	itc	itc	PROPN
admet-733	228	25	can	can	AUX
admet-733	228	26	also	also	ADV
admet-733	228	27	provide	provide	VERB
admet-733	228	28	the	the	DET
admet-733	228	29	values	value	NOUN
admet-733	228	30	of	of	ADP
admet-733	228	31	the	the	DET
admet-733	228	32	thermodynamic	thermodynamic	ADJ
admet-733	228	33	contributions	contribution	NOUN
admet-733	228	34	(	(	PUNCT
admet-733	228	35	enthalpy	enthalpy	NOUN
admet-733	228	36	,	,	PUNCT
admet-733	228	37	h	h	NOUN
admet-733	228	38	and	and	CCONJ
admet-733	228	39	entropy	entropy	NOUN
admet-733	228	40	,	,	PUNCT
admet-733	228	41	s	s	NOUN
admet-733	228	42	)	)	PUNCT
admet-733	228	43	to	to	ADP
admet-733	228	44	the	the	DET
admet-733	228	45	binding	bind	VERB
admet-733	228	46	affinity	affinity	NOUN
admet-733	228	47	directly	directly	ADV
admet-733	228	48	,	,	PUNCT
admet-733	228	49	and	and	CCONJ
admet-733	228	50	from	from	ADP
admet-733	228	51	the	the	DET
admet-733	228	52	temperature	temperature	NOUN
admet-733	228	53	dependence	dependence	NOUN
admet-733	228	54	of	of	ADP
admet-733	228	55	the	the	DET
admet-733	228	56	kd	kd	PROPN
admet-733	228	57	values	value	NOUN
admet-733	228	58	,	,	PUNCT
admet-733	228	59	van’t	van’t	NUM
admet-733	228	60	hoff	hoff	NOUN
admet-733	228	61	values	value	NOUN
admet-733	228	62	can	can	AUX
admet-733	228	63	be	be	AUX
admet-733	228	64	calculated	calculate	VERB
admet-733	228	65	from	from	ADP
admet-733	228	66	any	any	PRON
admet-733	228	67	of	of	ADP
admet-733	228	68	the	the	DET
admet-733	228	69	other	other	ADJ
admet-733	228	70	biophysical	biophysical	ADJ
admet-733	228	71	methods	method	NOUN
admet-733	228	72	.	.	PUNCT
admet-733	229	1	the	the	DET
admet-733	229	2	same	same	ADJ
admet-733	229	3	temperature	temperature	NOUN
admet-733	229	4	dependent	dependent	ADJ
admet-733	229	5	studies	study	NOUN
admet-733	229	6	for	for	ADP
admet-733	229	7	the	the	DET
admet-733	229	8	association	association	NOUN
admet-733	229	9	and	and	CCONJ
admet-733	229	10	dissociation	dissociation	NOUN
admet-733	229	11	rate	rate	NOUN
admet-733	229	12	constants	constant	NOUN
admet-733	229	13	measured	measure	VERB
admet-733	229	14	by	by	ADP
admet-733	229	15	spr	spr	ADJ
admet-733	229	16	lead	lead	NOUN
admet-733	229	17	to	to	ADP
admet-733	229	18	transition	transition	NOUN
admet-733	229	19	state	state	NOUN
admet-733	229	20	energies	energy	NOUN
admet-733	229	21	for	for	ADP
admet-733	229	22	the	the	DET
admet-733	229	23	association	association	NOUN
admet-733	229	24	and	and	CCONJ
admet-733	229	25	dissociation	dissociation	NOUN
admet-733	229	26	steps	step	NOUN
admet-733	229	27	of	of	ADP
admet-733	229	28	the	the	DET
admet-733	229	29	binding	bind	VERB
admet-733	229	30	reaction	reaction	NOUN
admet-733	229	31	which	which	PRON
admet-733	229	32	enables	enable	VERB
admet-733	229	33	construction	construction	NOUN
admet-733	229	34	of	of	ADP
admet-733	229	35	detailed	detailed	ADJ
admet-733	229	36	thermodynamic	thermodynamic	ADJ
admet-733	229	37	reaction	reaction	NOUN
admet-733	229	38	pathway	pathway	NOUN
admet-733	229	39	models	model	NOUN
admet-733	229	40	for	for	ADP
admet-733	229	41	protein	protein	NOUN
admet-733	229	42	-	-	PUNCT
admet-733	229	43	ligand	ligand	NOUN
admet-733	229	44	binding	binding	NOUN
admet-733	229	45	.	.	PUNCT
admet-733	230	1	these	these	DET
admet-733	230	2	approaches	approach	NOUN
admet-733	230	3	were	be	AUX
admet-733	230	4	used	use	VERB
admet-733	230	5	to	to	PART
admet-733	230	6	provide	provide	VERB
admet-733	230	7	structural	structural	ADJ
admet-733	230	8	and	and	CCONJ
admet-733	230	9	dynamic	dynamic	ADJ
admet-733	230	10	insights	insight	NOUN
admet-733	230	11	into	into	ADP
admet-733	230	12	the	the	DET
admet-733	230	13	binding	binding	NOUN
admet-733	230	14	of	of	ADP
admet-733	230	15	different	different	ADJ
admet-733	230	16	compounds	compound	NOUN
admet-733	230	17	to	to	ADP
admet-733	230	18	fgfr1	fgfr1	PROPN
admet-733	230	19	kinase	kinase	PROPN
admet-733	230	20	,	,	PUNCT
admet-733	230	21	to	to	PART
admet-733	230	22	understand	understand	VERB
admet-733	230	23	the	the	DET
admet-733	230	24	energetics	energetic	NOUN
admet-733	230	25	required	require	VERB
admet-733	230	26	for	for	ADP
admet-733	230	27	movement	movement	NOUN
admet-733	230	28	of	of	ADP
admet-733	230	29	the	the	DET
admet-733	230	30	activation	activation	NOUN
admet-733	230	31	loop	loop	NOUN
admet-733	230	32	[	[	X
admet-733	230	33	37	37	NUM
admet-733	230	34	]	]	PUNCT
admet-733	230	35	.	.	PUNCT
admet-733	231	1	although	although	SCONJ
admet-733	231	2	,	,	PUNCT
admet-733	231	3	it	it	PRON
admet-733	231	4	can	can	AUX
admet-733	231	5	be	be	AUX
admet-733	231	6	difficult	difficult	ADJ
admet-733	231	7	to	to	PART
admet-733	231	8	predict	predict	VERB
admet-733	231	9	these	these	DET
admet-733	231	10	values	value	NOUN
admet-733	231	11	or	or	CCONJ
admet-733	231	12	to	to	PART
admet-733	231	13	use	use	VERB
admet-733	231	14	this	this	DET
admet-733	231	15	type	type	NOUN
admet-733	231	16	of	of	ADP
admet-733	231	17	thermodynamic	thermodynamic	ADJ
admet-733	231	18	data	datum	NOUN
admet-733	231	19	directly	directly	ADV
admet-733	231	20	to	to	PART
admet-733	231	21	design	design	VERB
admet-733	231	22	new	new	ADJ
admet-733	231	23	compounds	compound	NOUN
admet-733	231	24	during	during	ADP
admet-733	231	25	lead	lead	ADJ
admet-733	231	26	optimisation	optimisation	NOUN
admet-733	231	27	,	,	PUNCT
admet-733	231	28	having	have	VERB
admet-733	231	29	the	the	DET
admet-733	231	30	ability	ability	NOUN
admet-733	231	31	to	to	PART
admet-733	231	32	dissect	dissect	VERB
admet-733	231	33	the	the	DET
admet-733	231	34	contributions	contribution	NOUN
admet-733	231	35	to	to	ADP
admet-733	231	36	binding	binding	ADJ
admet-733	231	37	and	and	CCONJ
admet-733	231	38	transition	transition	NOUN
admet-733	231	39	state	state	NOUN
admet-733	231	40	free	free	ADJ
admet-733	231	41	energies	energy	NOUN
admet-733	231	42	can	can	AUX
admet-733	231	43	provide	provide	VERB
admet-733	231	44	valuable	valuable	ADJ
admet-733	231	45	understanding	understanding	NOUN
admet-733	231	46	that	that	PRON
admet-733	231	47	will	will	AUX
admet-733	231	48	ultimately	ultimately	ADV
admet-733	231	49	lead	lead	VERB
admet-733	231	50	to	to	ADP
admet-733	231	51	a	a	DET
admet-733	231	52	more	more	ADV
admet-733	231	53	thorough	thorough	ADJ
admet-733	231	54	appreciation	appreciation	NOUN
admet-733	231	55	of	of	ADP
admet-733	231	56	the	the	DET
admet-733	231	57	features	feature	NOUN
admet-733	231	58	that	that	PRON
admet-733	231	59	contribute	contribute	VERB
admet-733	231	60	to	to	ADP
admet-733	231	61	high	high	ADJ
admet-733	231	62	affinity	affinity	NOUN
admet-733	231	63	binding	bind	VERB
admet-733	231	64	interactions	interaction	NOUN
admet-733	231	65	.	.	PUNCT
admet-733	232	1	more	more	ADJ
admet-733	232	2	interest	interest	NOUN
admet-733	232	3	,	,	PUNCT
admet-733	232	4	perhaps	perhaps	ADV
admet-733	232	5	rightly	rightly	ADV
admet-733	232	6	,	,	PUNCT
admet-733	232	7	seems	seem	VERB
admet-733	232	8	to	to	PART
admet-733	232	9	have	have	AUX
admet-733	232	10	been	be	AUX
admet-733	232	11	focussed	focusse	VERB
admet-733	232	12	on	on	ADP
admet-733	232	13	kinetic	kinetic	ADJ
admet-733	232	14	parameters	parameter	NOUN
admet-733	232	15	compared	compare	VERB
admet-733	232	16	to	to	ADP
admet-733	232	17	thermodynamic	thermodynamic	ADJ
admet-733	232	18	data	datum	NOUN
admet-733	232	19	and	and	CCONJ
admet-733	232	20	the	the	DET
admet-733	232	21	value	value	NOUN
admet-733	232	22	of	of	ADP
admet-733	232	23	combining	combine	VERB
admet-733	232	24	knowledge	knowledge	NOUN
admet-733	232	25	of	of	ADP
admet-733	232	26	target	target	NOUN
admet-733	232	27	-	-	PUNCT
admet-733	232	28	compound	compound	NOUN
admet-733	232	29	residence	residence	NOUN
admet-733	232	30	times	time	NOUN
admet-733	232	31	with	with	ADP
admet-733	232	32	pharmacokinetic	pharmacokinetic	ADJ
admet-733	232	33	(	(	PUNCT
admet-733	232	34	pk	pk	NOUN
admet-733	232	35	)	)	PUNCT
admet-733	232	36	and	and	CCONJ
admet-733	232	37	pharmacodynamic	pharmacodynamic	ADJ
admet-733	232	38	(	(	PUNCT
admet-733	232	39	pd	pd	NOUN
admet-733	232	40	)	)	PUNCT
admet-733	232	41	data	datum	NOUN
admet-733	232	42	seems	seem	VERB
admet-733	232	43	to	to	PART
admet-733	232	44	be	be	AUX
admet-733	232	45	gaining	gain	VERB
admet-733	232	46	awareness	awareness	NOUN
admet-733	233	1	[	[	X
admet-733	233	2	38	38	NUM
admet-733	233	3	]	]	PUNCT
admet-733	233	4	.	.	PUNCT
admet-733	234	1	the	the	DET
admet-733	234	2	ability	ability	NOUN
admet-733	234	3	to	to	PART
admet-733	234	4	combine	combine	VERB
admet-733	234	5	kinetic	kinetic	ADJ
admet-733	234	6	data	datum	NOUN
admet-733	234	7	from	from	ADP
admet-733	234	8	spr	spr	ADV
admet-733	234	9	on	on	ADP
admet-733	234	10	isolated	isolated	ADJ
admet-733	234	11	proteins	protein	NOUN
admet-733	234	12	with	with	ADP
admet-733	234	13	data	datum	NOUN
admet-733	234	14	from	from	ADP
admet-733	234	15	cell	cell	NOUN
admet-733	234	16	washout	washout	NOUN
admet-733	234	17	experiments	experiment	NOUN
admet-733	234	18	provides	provide	VERB
admet-733	234	19	an	an	DET
admet-733	234	20	extra	extra	ADJ
admet-733	234	21	level	level	NOUN
admet-733	234	22	of	of	ADP
admet-733	234	23	information	information	NOUN
admet-733	234	24	during	during	ADP
admet-733	234	25	lead	lead	ADJ
admet-733	234	26	optimisation	optimisation	NOUN
admet-733	234	27	.	.	PUNCT
admet-733	235	1	for	for	ADP
admet-733	235	2	example	example	NOUN
admet-733	235	3	,	,	PUNCT
admet-733	235	4	the	the	DET
admet-733	235	5	utility	utility	NOUN
admet-733	235	6	of	of	ADP
admet-733	235	7	pk	pk	NOUN
admet-733	235	8	/	/	SYM
admet-733	235	9	pd	pd	NOUN
admet-733	235	10	modelling	modelling	NOUN
admet-733	235	11	,	,	PUNCT
admet-733	235	12	which	which	PRON
admet-733	235	13	attempts	attempt	VERB
admet-733	235	14	to	to	PART
admet-733	235	15	describe	describe	VERB
admet-733	235	16	the	the	DET
admet-733	235	17	kinetics	kinetic	NOUN
admet-733	235	18	of	of	ADP
admet-733	235	19	the	the	DET
admet-733	235	20	effects	effect	NOUN
admet-733	235	21	of	of	ADP
admet-733	235	22	compound	compound	NOUN
admet-733	235	23	following	follow	VERB
admet-733	235	24	administration	administration	NOUN
admet-733	235	25	,	,	PUNCT
admet-733	235	26	is	be	AUX
admet-733	235	27	likely	likely	ADJ
admet-733	235	28	to	to	PART
admet-733	235	29	be	be	AUX
admet-733	235	30	enhanced	enhance	VERB
admet-733	235	31	by	by	ADP
admet-733	235	32	direct	direct	ADJ
admet-733	235	33	measurements	measurement	NOUN
admet-733	235	34	of	of	ADP
admet-733	235	35	the	the	DET
admet-733	235	36	kinetics	kinetic	NOUN
admet-733	235	37	of	of	ADP
admet-733	235	38	compound	compound	NOUN
admet-733	235	39	binding	bind	VERB
admet-733	235	40	and	and	CCONJ
admet-733	235	41	target	target	VERB
admet-733	235	42	turnover	turnover	NOUN
admet-733	235	43	.	.	PUNCT
admet-733	236	1	case	case	NOUN
admet-733	236	2	study	study	VERB
admet-733	236	3	1	1	NUM
admet-733	236	4	biophysical	biophysical	ADJ
admet-733	236	5	characterisation	characterisation	NOUN
admet-733	236	6	of	of	ADP
admet-733	236	7	phgdh	phgdh	NOUN
admet-733	236	8	fragment	fragment	NOUN
admet-733	236	9	hits	hit	VERB
admet-733	236	10	the	the	DET
admet-733	236	11	enzyme	enzyme	NOUN
admet-733	236	12	3	3	NUM
admet-733	236	13	-	-	PUNCT
admet-733	236	14	phosphohydroxyglycerate	phosphohydroxyglycerate	NOUN
admet-733	236	15	dehydrogenase	dehydrogenase	NOUN
admet-733	236	16	(	(	PUNCT
admet-733	236	17	phgdh	phgdh	NOUN
admet-733	236	18	)	)	PUNCT
admet-733	236	19	utilises	utilise	NOUN
admet-733	236	20	oxidised	oxidise	VERB
admet-733	236	21	ninotinamide	ninotinamide	ADJ
admet-733	236	22	dinucleotide	dinucleotide	NOUN
admet-733	236	23	(	(	PUNCT
admet-733	236	24	nad+	nad+	NOUN
admet-733	236	25	)	)	PUNCT
admet-733	236	26	and	and	CCONJ
admet-733	236	27	catalyses	catalyse	VERB
admet-733	236	28	the	the	DET
admet-733	236	29	conversion	conversion	NOUN
admet-733	236	30	of	of	ADP
admet-733	236	31	3	3	NUM
admet-733	236	32	-	-	PUNCT
admet-733	236	33	phosphohydroxyglycerate	phosphohydroxyglycerate	NOUN
admet-733	236	34	to	to	ADP
admet-733	236	35	3phosphohydroxypyruvate	3phosphohydroxypyruvate	PROPN
admet-733	236	36	in	in	ADP
admet-733	236	37	humans	human	NOUN
admet-733	236	38	.	.	PUNCT
admet-733	237	1	the	the	DET
admet-733	237	2	conversion	conversion	NOUN
admet-733	237	3	of	of	ADP
admet-733	237	4	3	3	NUM
admet-733	237	5	-	-	PUNCT
admet-733	237	6	phosphohydroxyglycerate	phosphohydroxyglycerate	NOUN
admet-733	237	7	to	to	ADP
admet-733	237	8	3phosphohydroxypyruvate	3phosphohydroxypyruvate	PROPN
admet-733	237	9	is	be	AUX
admet-733	237	10	the	the	DET
admet-733	237	11	first	first	ADJ
admet-733	237	12	,	,	PUNCT
admet-733	237	13	and	and	CCONJ
admet-733	237	14	rate	rate	NOUN
admet-733	237	15	-	-	PUNCT
admet-733	237	16	limiting	limit	VERB
admet-733	237	17	step	step	NOUN
admet-733	237	18	,	,	PUNCT
admet-733	237	19	in	in	ADP
admet-733	237	20	synthesis	synthesis	NOUN
admet-733	237	21	of	of	ADP
admet-733	237	22	the	the	DET
admet-733	237	23	amino	amino	NOUN
admet-733	237	24	acid	acid	NOUN
admet-733	237	25	serine	serine	NOUN
admet-733	237	26	.	.	PUNCT
admet-733	238	1	studies	study	NOUN
admet-733	238	2	have	have	AUX
admet-733	238	3	linked	link	VERB
admet-733	238	4	phgdh	phgdh	NOUN
admet-733	238	5	to	to	ADP
admet-733	238	6	the	the	DET
admet-733	238	7	in	in	ADP
admet-733	238	8	vivo	vivo	ADJ
admet-733	238	9	tumourigenesis	tumourigenesis	NOUN
admet-733	238	10	in	in	ADP
admet-733	238	11	aggressive	aggressive	ADJ
admet-733	238	12	breast	breast	NOUN
admet-733	238	13	tumours	tumour	NOUN
admet-733	238	14	and	and	CCONJ
admet-733	238	15	functional	functional	ADJ
admet-733	238	16	genomics	genomic	NOUN
admet-733	238	17	reveal	reveal	VERB
admet-733	238	18	that	that	SCONJ
admet-733	238	19	the	the	DET
admet-733	238	20	serine	serine	ADJ
admet-733	238	21	synthesis	synthesis	NOUN
admet-733	238	22	pathway	pathway	NOUN
admet-733	238	23	is	be	AUX
admet-733	238	24	essential	essential	ADJ
admet-733	238	25	in	in	ADP
admet-733	238	26	breast	breast	NOUN
admet-733	238	27	cancer	cancer	NOUN
admet-733	239	1	[	[	X
admet-733	239	2	39	39	NUM
admet-733	239	3	]	]	PUNCT
admet-733	239	4	.	.	PUNCT
admet-733	240	1	thus	thus	ADV
admet-733	240	2	,	,	PUNCT
admet-733	240	3	the	the	DET
admet-733	240	4	druggability	druggability	NOUN
admet-733	240	5	of	of	ADP
admet-733	240	6	the	the	DET
admet-733	240	7	target	target	NOUN
admet-733	240	8	was	be	AUX
admet-733	240	9	explored	explore	VERB
admet-733	240	10	with	with	ADP
admet-733	240	11	small	small	ADJ
admet-733	240	12	molecules	molecule	NOUN
admet-733	240	13	.	.	PUNCT
admet-733	241	1	to	to	ADP
admet-733	241	2	this	this	DET
admet-733	241	3	end	end	NOUN
admet-733	241	4	a	a	DET
admet-733	241	5	fragment	fragment	ADJ
admet-733	241	6	screen	screen	NOUN
admet-733	241	7	of	of	ADP
admet-733	241	8	384	384	NUM
admet-733	241	9	fragments	fragment	NOUN
admet-733	241	10	was	be	AUX
admet-733	241	11	undertaken	undertake	VERB
admet-733	241	12	using	use	VERB
admet-733	241	13	crystal	crystal	NOUN
admet-733	241	14	cocktail	cocktail	NOUN
admet-733	241	15	soaking	soaking	NOUN
admet-733	241	16	(	(	PUNCT
admet-733	241	17	mixtures	mixture	NOUN
admet-733	241	18	of	of	ADP
admet-733	241	19	4	4	NUM
admet-733	241	20	)	)	PUNCT
admet-733	241	21	against	against	ADP
admet-733	241	22	the	the	DET
admet-733	241	23	nad	nad	ADJ
admet-733	241	24	binding	bind	VERB
admet-733	241	25	domain	domain	NOUN
admet-733	241	26	of	of	ADP
admet-733	241	27	phgdh	phgdh	NOUN
admet-733	241	28	and	and	CCONJ
admet-733	241	29	34	34	NUM
admet-733	241	30	hits	hit	NOUN
admet-733	241	31	were	be	AUX
admet-733	241	32	identified	identify	VERB
admet-733	241	33	.	.	PUNCT
admet-733	242	1	the	the	DET
admet-733	242	2	binding	bind	VERB
admet-733	242	3	affinities	affinity	NOUN
admet-733	242	4	of	of	ADP
admet-733	242	5	these	these	DET
admet-733	242	6	hits	hit	NOUN
admet-733	242	7	were	be	AUX
admet-733	242	8	determined	determine	VERB
admet-733	242	9	in	in	ADP
admet-733	242	10	a	a	DET
admet-733	242	11	2d	2d	NUM
admet-733	242	12	nmr	nmr	NOUN
admet-733	242	13	binding	bind	VERB
admet-733	242	14	assay	assay	NOUN
admet-733	242	15	using	use	VERB
admet-733	242	16	15nlabeled	15nlabele	VERB
admet-733	242	17	nad	nad	ADJ
admet-733	242	18	binding	bind	VERB
admet-733	242	19	domain	domain	NOUN
admet-733	242	20	,	,	PUNCT
admet-733	242	21	figure	figure	VERB
admet-733	242	22	6a	6a	NOUN
admet-733	242	23	.	.	PUNCT
admet-733	243	1	these	these	DET
admet-733	243	2	data	datum	NOUN
admet-733	243	3	,	,	PUNCT
admet-733	243	4	in	in	ADP
admet-733	243	5	conjunction	conjunction	NOUN
admet-733	243	6	with	with	ADP
admet-733	243	7	x	x	ADJ
admet-733	243	8	-	-	NOUN
admet-733	243	9	ray	ray	NOUN
admet-733	243	10	crystallography	crystallography	NOUN
admet-733	243	11	data	datum	NOUN
admet-733	243	12	,	,	PUNCT
admet-733	243	13	figure	figure	NOUN
admet-733	243	14	6b	6b	NOUN
admet-733	243	15	,	,	PUNCT
admet-733	243	16	were	be	AUX
admet-733	243	17	used	use	VERB
admet-733	243	18	to	to	PART
admet-733	243	19	identify	identify	VERB
admet-733	243	20	fragments	fragment	NOUN
admet-733	243	21	with	with	ADP
admet-733	243	22	the	the	DET
admet-733	243	23	greatest	great	ADJ
admet-733	243	24	potential	potential	NOUN
admet-733	243	25	for	for	ADP
admet-733	243	26	development	development	NOUN
admet-733	243	27	,	,	PUNCT
admet-733	243	28	scheme	scheme	NOUN
admet-733	243	29	1	1	NUM
admet-733	243	30	.	.	PUNCT
admet-733	243	31	a	a	DET
admet-733	243	32	simple	simple	ADJ
admet-733	243	33	analogue	analogue	NOUN
admet-733	243	34	of	of	ADP
admet-733	243	35	an	an	DET
admet-733	243	36	initial	initial	ADJ
admet-733	243	37	crystallography	crystallography	NOUN
admet-733	243	38	hit	hit	NOUN
admet-733	243	39	(	(	PUNCT
admet-733	243	40	compound	compound	NOUN
admet-733	243	41	1	1	NUM
admet-733	243	42	)	)	PUNCT
admet-733	243	43	,	,	PUNCT
admet-733	243	44	the	the	DET
admet-733	243	45	5	5	NUM
admet-733	243	46	-	-	PUNCT
admet-733	243	47	fluoroindole-2	fluoroindole-2	NUM
admet-733	243	48	-	-	PUNCT
admet-733	243	49	carboxamide	carboxamide	NOUN
admet-733	243	50	(	(	PUNCT
admet-733	243	51	compound	compound	NOUN
admet-733	243	52	2	2	NUM
admet-733	243	53	)	)	PUNCT
admet-733	243	54	bound	bind	VERB
admet-733	243	55	at	at	ADP
admet-733	243	56	a	a	DET
admet-733	243	57	resolution	resolution	NOUN
admet-733	243	58	of	of	ADP
admet-733	243	59	1.95	1.95	NUM
admet-733	243	60	å	å	NOUN
admet-733	243	61	in	in	ADP
admet-733	243	62	the	the	DET
admet-733	243	63	adenine	adenine	ADJ
admet-733	243	64	pocket	pocket	NOUN
admet-733	243	65	of	of	ADP
admet-733	243	66	the	the	DET
admet-733	243	67	nad	nad	ADJ
admet-733	243	68	binding	bind	VERB
admet-733	243	69	site	site	NOUN
admet-733	243	70	(	(	PUNCT
admet-733	243	71	figure	figure	NOUN
admet-733	243	72	6b	6b	NUM
admet-733	243	73	)	)	PUNCT
admet-733	243	74	.	.	PUNCT
admet-733	244	1	the	the	DET
admet-733	244	2	indole	indole	ADJ
admet-733	244	3	nh	nh	PROPN
admet-733	244	4	forms	form	VERB
admet-733	244	5	a	a	DET
admet-733	244	6	water	water	NOUN
admet-733	244	7	-	-	PUNCT
admet-733	244	8	bridged	bridge	VERB
admet-733	244	9	hydrogen	hydrogen	NOUN
admet-733	244	10	bond	bond	NOUN
admet-733	244	11	network	network	NOUN
admet-733	244	12	with	with	ADP
admet-733	244	13	ser-211	ser-211	NOUN
admet-733	244	14	,	,	PUNCT
admet-733	244	15	and	and	CCONJ
admet-733	244	16	the	the	DET
admet-733	244	17	5	5	NUM
admet-733	244	18	-	-	PUNCT
admet-733	244	19	fluoro	fluoro	NOUN
admet-733	244	20	substituent	substituent	NOUN
admet-733	244	21	fits	fit	VERB
admet-733	244	22	nicely	nicely	ADV
admet-733	244	23	into	into	ADP
admet-733	244	24	a	a	DET
admet-733	244	25	lipophilic	lipophilic	ADJ
admet-733	244	26	cleft	cleft	NOUN
admet-733	244	27	in	in	ADP
admet-733	244	28	the	the	DET
admet-733	244	29	binding	bind	VERB
admet-733	244	30	pocket	pocket	NOUN
admet-733	244	31	.	.	PUNCT
admet-733	245	1	in	in	ADP
admet-733	245	2	addition	addition	NOUN
admet-733	245	3	,	,	PUNCT
admet-733	245	4	the	the	DET
admet-733	245	5	carboxamide	carboxamide	NOUN
admet-733	245	6	of	of	ADP
admet-733	245	7	compound	compound	NOUN
admet-733	245	8	2	2	NUM
admet-733	245	9	makes	make	VERB
admet-733	245	10	a	a	DET
admet-733	245	11	water	water	NOUN
admet-733	245	12	-	-	PUNCT
admet-733	245	13	bridged	bridge	VERB
admet-733	245	14	interaction	interaction	NOUN
admet-733	245	15	with	with	ADP
admet-733	245	16	asp-174	asp-174	ADP
admet-733	245	17	and	and	CCONJ
admet-733	245	18	the	the	DET
admet-733	245	19	crystal	crystal	NOUN
admet-733	245	20	structure	structure	NOUN
admet-733	245	21	shows	show	VERB
admet-733	245	22	favourable	favourable	ADJ
admet-733	245	23	vectors	vector	NOUN
admet-733	245	24	to	to	PART
admet-733	245	25	grow	grow	VERB
admet-733	245	26	the	the	DET
admet-733	245	27	fragment	fragment	NOUN
admet-733	245	28	into	into	ADP
admet-733	245	29	the	the	DET
admet-733	245	30	phosphate	phosphate	ADJ
admet-733	245	31	binding	bind	VERB
admet-733	245	32	site	site	NOUN
admet-733	245	33	.	.	PUNCT
admet-733	246	1	in	in	ADP
admet-733	246	2	this	this	DET
admet-733	246	3	endeavour	endeavour	NOUN
admet-733	246	4	,	,	PUNCT
admet-733	246	5	compounds	compound	NOUN
admet-733	246	6	were	be	AUX
admet-733	246	7	made	make	VERB
admet-733	246	8	that	that	PRON
admet-733	246	9	should	should	AUX
admet-733	246	10	displace	displace	VERB
admet-733	246	11	the	the	DET
admet-733	246	12	water	water	NOUN
admet-733	246	13	mediating	mediate	VERB
admet-733	246	14	the	the	DET
admet-733	246	15	hydrogen	hydrogen	NOUN
admet-733	246	16	bond	bond	NOUN
admet-733	246	17	interaction	interaction	NOUN
admet-733	246	18	between	between	ADP
admet-733	246	19	the	the	DET
admet-733	246	20	carboxamide	carboxamide	NOUN
admet-733	246	21	of	of	ADP
admet-733	246	22	compound	compound	NOUN
admet-733	246	23	2	2	NUM
admet-733	246	24	and	and	CCONJ
admet-733	246	25	asp-174	asp-174	ADJ
admet-733	246	26	.	.	PUNCT
admet-733	247	1	the	the	DET
admet-733	247	2	synthesis	synthesis	NOUN
admet-733	247	3	of	of	ADP
admet-733	247	4	the	the	DET
admet-733	247	5	α	α	NOUN
admet-733	247	6	-	-	PUNCT
admet-733	247	7	hydroxymethylbenzylamide	hydroxymethylbenzylamide	NOUN
admet-733	247	8	,	,	PUNCT
admet-733	247	9	compound	compound	NOUN
admet-733	247	10	4	4	NUM
admet-733	247	11	,	,	PUNCT
admet-733	247	12	led	lead	VERB
admet-733	247	13	to	to	ADP
admet-733	247	14	improved	improve	VERB
admet-733	247	15	affinity	affinity	NOUN
admet-733	247	16	to	to	ADP
admet-733	247	17	the	the	DET
admet-733	247	18	single	single	ADJ
admet-733	247	19	digit	digit	NOUN
admet-733	247	20	µm	µm	ADP
admet-733	247	21	.	.	PUNCT
admet-733	248	1	a	a	DET
admet-733	248	2	crystal	crystal	NOUN
admet-733	248	3	structure	structure	NOUN
admet-733	248	4	of	of	ADP
admet-733	248	5	compound	compound	NOUN
admet-733	248	6	4	4	NUM
admet-733	248	7	(	(	PUNCT
admet-733	248	8	figure	figure	NOUN
admet-733	248	9	6c	6c	PROPN
admet-733	248	10	)	)	PUNCT
admet-733	248	11	showed	show	VERB
admet-733	248	12	clear	clear	ADJ
admet-733	248	13	opportunities	opportunity	NOUN
admet-733	248	14	to	to	PART
admet-733	248	15	further	far	ADV
admet-733	248	16	explore	explore	VERB
admet-733	248	17	the	the	DET
admet-733	248	18	phosphate	phosphate	ADJ
admet-733	248	19	binding	bind	VERB
admet-733	248	20	pocket	pocket	NOUN
admet-733	248	21	by	by	ADP
admet-733	248	22	installing	instal	VERB
admet-733	248	23	additional	additional	ADJ
admet-733	248	24	functionality	functionality	NOUN
admet-733	248	25	on	on	ADP
admet-733	248	26	the	the	DET
admet-733	248	27	phenyl	phenyl	NOUN
admet-733	248	28	ring	ring	NOUN
admet-733	248	29	of	of	ADP
admet-733	248	30	the	the	DET
admet-733	248	31	benzyl	benzyl	NOUN
admet-733	248	32	amide	amide	NOUN
admet-733	248	33	and	and	CCONJ
admet-733	248	34	this	this	PRON
admet-733	248	35	led	lead	VERB
admet-733	248	36	to	to	ADP
admet-733	248	37	the	the	DET
admet-733	248	38	synthesis	synthesis	NOUN
admet-733	248	39	of	of	ADP
admet-733	248	40	compound	compound	NOUN
admet-733	248	41	5	5	NUM
admet-733	248	42	with	with	ADP
admet-733	248	43	a	a	DET
admet-733	248	44	further	further	ADJ
admet-733	248	45	10	10	NUM
admet-733	248	46	-	-	ADJ
admet-733	248	47	fold	fold	ADJ
admet-733	248	48	improvement	improvement	NOUN
admet-733	248	49	in	in	ADP
admet-733	248	50	affinity	affinity	NOUN
admet-733	248	51	.	.	PUNCT
admet-733	249	1	holdgate	holdgate	VERB
admet-733	249	2	et	et	PROPN
admet-733	249	3	al	al	PROPN
admet-733	249	4	.	.	PROPN
admet-733	249	5	admet	admet	PROPN
admet-733	249	6	&	&	CCONJ
admet-733	249	7	dmpk	dmpk	PROPN
admet-733	249	8	7(4	7(4	NUM
admet-733	249	9	)	)	PUNCT
admet-733	249	10	(	(	PUNCT
admet-733	249	11	2019	2019	NUM
admet-733	249	12	)	)	PUNCT
admet-733	249	13	222	222	NUM
admet-733	249	14	-	-	SYM
admet-733	249	15	241	241	NUM
admet-733	249	16	236	236	NUM
admet-733	249	17	figure	figure	NOUN
admet-733	249	18	6	6	NUM
admet-733	249	19	(	(	PUNCT
admet-733	249	20	a	a	DET
admet-733	249	21	)	)	PUNCT
admet-733	249	22	1h15n	1h15n	NUM
admet-733	249	23	-	-	PUNCT
admet-733	249	24	trosyhsqc	trosyhsqc	NOUN
admet-733	249	25	spectra	spectra	NOUN
admet-733	249	26	illustrating	illustrate	VERB
admet-733	249	27	binding	bind	VERB
admet-733	249	28	of	of	ADP
admet-733	249	29	compound	compound	NOUN
admet-733	249	30	2	2	NUM
admet-733	249	31	,	,	PUNCT
admet-733	249	32	compound	compound	NOUN
admet-733	249	33	concentrations	concentration	NOUN
admet-733	249	34	used	use	VERB
admet-733	249	35	are	be	AUX
admet-733	249	36	shown	show	VERB
admet-733	249	37	as	as	SCONJ
admet-733	249	38	is	be	AUX
admet-733	249	39	the	the	DET
admet-733	249	40	plot	plot	NOUN
admet-733	249	41	of	of	ADP
admet-733	249	42	the	the	DET
admet-733	249	43	chemical	chemical	NOUN
admet-733	249	44	shift	shift	NOUN
admet-733	249	45	change	change	NOUN
admet-733	249	46	versus	versus	ADP
admet-733	249	47	compound	compound	NOUN
admet-733	249	48	concentration	concentration	NOUN
admet-733	249	49	used	use	VERB
admet-733	249	50	to	to	PART
admet-733	249	51	determine	determine	VERB
admet-733	249	52	the	the	DET
admet-733	249	53	affinity	affinity	NOUN
admet-733	249	54	(	(	PUNCT
admet-733	249	55	kd	kd	NOUN
admet-733	249	56	=	=	PROPN
admet-733	249	57	980	980	NUM
admet-733	249	58	±	±	NUM
admet-733	249	59	60	60	NUM
admet-733	249	60	µm	µm	NOUN
admet-733	249	61	)	)	PUNCT
admet-733	249	62	;	;	PUNCT
admet-733	249	63	(	(	PUNCT
admet-733	249	64	b	b	X
admet-733	249	65	)	)	PUNCT
admet-733	249	66	crystal	crystal	NOUN
admet-733	249	67	structure	structure	NOUN
admet-733	249	68	of	of	ADP
admet-733	249	69	compound	compound	NOUN
admet-733	249	70	2	2	NUM
admet-733	249	71	bound	bind	VERB
admet-733	249	72	at	at	ADP
admet-733	249	73	a	a	DET
admet-733	249	74	resolution	resolution	NOUN
admet-733	249	75	of	of	ADP
admet-733	249	76	1.95	1.95	NUM
admet-733	249	77	å	å	NOUN
admet-733	249	78	in	in	ADP
admet-733	249	79	the	the	DET
admet-733	249	80	adenine	adenine	ADJ
admet-733	249	81	pocket	pocket	NOUN
admet-733	249	82	of	of	ADP
admet-733	249	83	the	the	DET
admet-733	249	84	nad	nad	ADJ
admet-733	249	85	binding	bind	VERB
admet-733	249	86	site	site	NOUN
admet-733	249	87	showing	show	VERB
admet-733	249	88	a	a	DET
admet-733	249	89	water	water	NOUN
admet-733	249	90	-	-	PUNCT
admet-733	249	91	bridged	bridge	VERB
admet-733	249	92	interaction	interaction	NOUN
admet-733	249	93	from	from	ADP
admet-733	249	94	the	the	DET
admet-733	249	95	carboxamide	carboxamide	NOUN
admet-733	249	96	to	to	ADP
admet-733	249	97	asp-174	asp-174	PROPN
admet-733	249	98	(	(	PUNCT
admet-733	249	99	c	c	NOUN
admet-733	249	100	)	)	PUNCT
admet-733	249	101	crystal	crystal	NOUN
admet-733	249	102	structure	structure	NOUN
admet-733	249	103	of	of	ADP
admet-733	249	104	compound	compound	NOUN
admet-733	249	105	4	4	NUM
admet-733	249	106	shows	show	VERB
admet-733	249	107	displacement	displacement	NOUN
admet-733	249	108	of	of	ADP
admet-733	249	109	the	the	DET
admet-733	249	110	water	water	NOUN
admet-733	249	111	mediated	mediate	VERB
admet-733	249	112	interaction	interaction	NOUN
admet-733	249	113	with	with	ADP
admet-733	249	114	asp-174	asp-174	NOUN
admet-733	249	115	and	and	CCONJ
admet-733	249	116	opportunities	opportunity	NOUN
admet-733	249	117	to	to	PART
admet-733	249	118	add	add	VERB
admet-733	249	119	additional	additional	ADJ
admet-733	249	120	functionality	functionality	NOUN
admet-733	249	121	on	on	ADP
admet-733	249	122	the	the	DET
admet-733	249	123	phenyl	phenyl	NOUN
admet-733	249	124	ring	ring	NOUN
admet-733	249	125	of	of	ADP
admet-733	249	126	the	the	DET
admet-733	249	127	benzyl	benzyl	NOUN
admet-733	249	128	amide	amide	NOUN
admet-733	249	129	,	,	PUNCT
admet-733	249	130	which	which	PRON
admet-733	249	131	led	lead	VERB
admet-733	249	132	to	to	ADP
admet-733	249	133	the	the	DET
admet-733	249	134	synthesis	synthesis	NOUN
admet-733	249	135	of	of	ADP
admet-733	249	136	compound	compound	NOUN
admet-733	249	137	5	5	NUM
admet-733	249	138	.	.	PUNCT
admet-733	250	1	despite	despite	SCONJ
admet-733	250	2	the	the	DET
admet-733	250	3	abundant	abundant	ADJ
admet-733	250	4	2d	2d	NUM
admet-733	250	5	nmr	nmr	NOUN
admet-733	250	6	and	and	CCONJ
admet-733	250	7	crystallography	crystallography	NOUN
admet-733	250	8	data	datum	NOUN
admet-733	250	9	clearly	clearly	ADV
admet-733	250	10	demonstrating	demonstrate	VERB
admet-733	250	11	that	that	SCONJ
admet-733	250	12	the	the	DET
admet-733	250	13	nad	nad	ADJ
admet-733	250	14	binding	bind	VERB
admet-733	250	15	domain	domain	NOUN
admet-733	250	16	of	of	ADP
admet-733	250	17	phgdh	phgdh	NOUN
admet-733	250	18	was	be	AUX
admet-733	250	19	a	a	DET
admet-733	250	20	folded	folded	ADJ
admet-733	250	21	and	and	CCONJ
admet-733	250	22	stable	stable	ADJ
admet-733	250	23	protein	protein	NOUN
admet-733	250	24	capable	capable	ADJ
admet-733	250	25	of	of	ADP
admet-733	250	26	binding	bind	VERB
admet-733	250	27	ligands	ligand	NOUN
admet-733	250	28	,	,	PUNCT
admet-733	250	29	further	further	ADJ
admet-733	250	30	biophysical	biophysical	ADJ
admet-733	250	31	data	datum	NOUN
admet-733	250	32	comparing	compare	VERB
admet-733	250	33	the	the	DET
admet-733	250	34	function	function	NOUN
admet-733	250	35	of	of	ADP
admet-733	250	36	this	this	DET
admet-733	250	37	domain	domain	NOUN
admet-733	250	38	with	with	ADP
admet-733	250	39	the	the	DET
admet-733	250	40	full	full	ADJ
admet-733	250	41	-	-	PUNCT
admet-733	250	42	length	length	NOUN
admet-733	250	43	protein	protein	NOUN
admet-733	250	44	highlighted	highlight	VERB
admet-733	250	45	differences	difference	NOUN
admet-733	250	46	.	.	PUNCT
admet-733	251	1	a	a	DET
admet-733	251	2	combination	combination	NOUN
admet-733	251	3	of	of	ADP
admet-733	251	4	itc	itc	PROPN
admet-733	251	5	and	and	CCONJ
admet-733	251	6	spr	spr	ADJ
admet-733	251	7	measurements	measurement	NOUN
admet-733	251	8	,	,	PUNCT
admet-733	251	9	figure	figure	NOUN
admet-733	251	10	7a	7a	NUM
admet-733	251	11	-	-	PUNCT
admet-733	251	12	c	c	NOUN
admet-733	251	13	,	,	PUNCT
admet-733	251	14	clearly	clearly	ADV
admet-733	251	15	demonstrate	demonstrate	VERB
admet-733	251	16	that	that	SCONJ
admet-733	251	17	nadh	nadh	NOUN
admet-733	251	18	binds	bind	VERB
admet-733	251	19	approximately	approximately	ADV
admet-733	251	20	20	20	NUM
admet-733	251	21	-	-	NUM
admet-733	251	22	fold	fold	VERB
admet-733	251	23	more	more	ADV
admet-733	251	24	tightly	tightly	ADV
admet-733	251	25	to	to	ADP
admet-733	251	26	the	the	DET
admet-733	251	27	full	full	ADJ
admet-733	251	28	-	-	PUNCT
admet-733	251	29	length	length	NOUN
admet-733	251	30	protein	protein	NOUN
admet-733	251	31	.	.	PUNCT
admet-733	252	1	considering	consider	VERB
admet-733	252	2	this	this	DET
admet-733	252	3	knowledge	knowledge	NOUN
admet-733	252	4	,	,	PUNCT
admet-733	252	5	a	a	DET
admet-733	252	6	1d	1d	NUM
admet-733	252	7	nmr	nmr	NOUN
admet-733	252	8	competition	competition	NOUN
admet-733	252	9	assay	assay	VERB
admet-733	252	10	with	with	ADP
admet-733	252	11	nad+	nad+	PROPN
admet-733	252	12	as	as	SCONJ
admet-733	252	13	the	the	DET
admet-733	252	14	reference	reference	NOUN
admet-733	252	15	compound	compound	NOUN
admet-733	252	16	was	be	AUX
admet-733	252	17	developed	develop	VERB
admet-733	252	18	.	.	PUNCT
admet-733	253	1	this	this	DET
admet-733	253	2	screen	screen	NOUN
admet-733	253	3	employed	employ	VERB
admet-733	253	4	the	the	DET
admet-733	253	5	more	more	ADV
admet-733	253	6	physiologically	physiologically	ADV
admet-733	253	7	relevant	relevant	ADJ
admet-733	253	8	full	full	ADJ
admet-733	253	9	length	length	NOUN
admet-733	253	10	phgdh	phgdh	NOUN
admet-733	253	11	protein	protein	NOUN
admet-733	253	12	,	,	PUNCT
admet-733	253	13	to	to	PART
admet-733	253	14	provide	provide	VERB
admet-733	253	15	continuity	continuity	NOUN
admet-733	253	16	for	for	ADP
admet-733	253	17	affinity	affinity	NOUN
admet-733	253	18	measurement	measurement	NOUN
admet-733	253	19	during	during	ADP
admet-733	253	20	the	the	DET
admet-733	253	21	subsequent	subsequent	ADJ
admet-733	253	22	analoguing	analoguing	NOUN
admet-733	253	23	phase	phase	NOUN
admet-733	253	24	.	.	PUNCT
admet-733	254	1	it	it	PRON
admet-733	254	2	is	be	AUX
admet-733	254	3	noteworthy	noteworthy	ADJ
admet-733	254	4	that	that	SCONJ
admet-733	254	5	fragments	fragment	NOUN
admet-733	254	6	and	and	CCONJ
admet-733	254	7	many	many	ADJ
admet-733	254	8	of	of	ADP
admet-733	254	9	the	the	DET
admet-733	254	10	synthesised	synthesise	VERB
admet-733	254	11	analogues	analogue	NOUN
admet-733	254	12	had	have	VERB
admet-733	254	13	no	no	DET
admet-733	254	14	measurable	measurable	ADJ
admet-733	254	15	activity	activity	NOUN
admet-733	254	16	in	in	ADP
admet-733	254	17	the	the	DET
admet-733	254	18	human	human	ADJ
admet-733	254	19	phgdh	phgdh	NOUN
admet-733	254	20	protein	protein	NOUN
admet-733	254	21	nad	nad	ADJ
admet-733	254	22	fluorescence	fluorescence	NOUN
admet-733	254	23	intensity	intensity	NOUN
admet-733	254	24	biochemical	biochemical	ADJ
admet-733	254	25	assay	assay	NOUN
admet-733	254	26	.	.	PUNCT
admet-733	255	1	whilst	whilst	SCONJ
admet-733	255	2	the	the	DET
admet-733	255	3	biophysical	biophysical	ADJ
admet-733	255	4	methods	method	NOUN
admet-733	255	5	allowed	allow	VERB
admet-733	255	6	a	a	DET
admet-733	255	7	wide	wide	ADJ
admet-733	255	8	dynamic	dynamic	ADJ
admet-733	255	9	range	range	NOUN
admet-733	255	10	of	of	ADP
admet-733	255	11	weak	weak	ADJ
admet-733	255	12	mm	mm	NOUN
admet-733	255	13	to	to	PART
admet-733	255	14	sub	sub	VERB
admet-733	255	15	µm	µm	ADP
admet-733	255	16	affinities	affinity	NOUN
admet-733	255	17	be	be	AUX
admet-733	255	18	determined	determine	VERB
admet-733	255	19	,	,	PUNCT
admet-733	255	20	the	the	DET
admet-733	255	21	biochemical	biochemical	ADJ
admet-733	255	22	assay	assay	NOUN
admet-733	255	23	could	could	AUX
admet-733	255	24	only	only	ADV
admet-733	255	25	be	be	AUX
admet-733	255	26	used	use	VERB
admet-733	255	27	to	to	PART
admet-733	255	28	provide	provide	VERB
admet-733	255	29	affinities	affinity	NOUN
admet-733	255	30	that	that	PRON
admet-733	255	31	could	could	AUX
admet-733	255	32	drive	drive	VERB
admet-733	255	33	sar	sar	PROPN
admet-733	255	34	once	once	SCONJ
admet-733	255	35	those	those	DET
admet-733	255	36	affinities	affinity	NOUN
admet-733	255	37	were	be	AUX
admet-733	255	38	sub	sub	NOUN
admet-733	255	39	micromolar	micromolar	ADJ
admet-733	255	40	.	.	PUNCT
admet-733	256	1	in	in	ADP
admet-733	256	2	summary	summary	NOUN
admet-733	256	3	,	,	PUNCT
admet-733	256	4	a	a	DET
admet-733	256	5	fragment	fragment	NOUN
admet-733	256	6	crystal	crystal	NOUN
admet-733	256	7	cocktail	cocktail	NOUN
admet-733	256	8	screen	screen	NOUN
admet-733	256	9	,	,	PUNCT
admet-733	256	10	supported	support	VERB
admet-733	256	11	with	with	ADP
admet-733	256	12	biophysical	biophysical	ADJ
admet-733	256	13	affinity	affinity	NOUN
admet-733	256	14	measurements	measurement	NOUN
admet-733	256	15	,	,	PUNCT
admet-733	256	16	provided	provide	VERB
admet-733	256	17	the	the	DET
admet-733	256	18	first	first	ADJ
admet-733	256	19	known	know	VERB
admet-733	256	20	small	small	ADJ
admet-733	256	21	molecule	molecule	NOUN
admet-733	256	22	known	know	VERB
admet-733	256	23	nanomolar	nanomolar	ADJ
admet-733	256	24	inhibitors	inhibitor	NOUN
admet-733	256	25	of	of	ADP
admet-733	256	26	phgdh	phgdh	ADJ
admet-733	256	27	and	and	CCONJ
admet-733	256	28	valuable	valuable	ADJ
admet-733	256	29	tools	tool	NOUN
admet-733	256	30	for	for	ADP
admet-733	256	31	interrogating	interrogate	VERB
admet-733	256	32	the	the	DET
admet-733	256	33	biology	biology	NOUN
admet-733	256	34	of	of	ADP
admet-733	256	35	this	this	DET
admet-733	256	36	target	target	NOUN
admet-733	256	37	.	.	PUNCT
admet-733	257	1	scheme	scheme	NOUN
admet-733	257	2	1	1	NUM
admet-733	257	3	.	.	PUNCT
admet-733	257	4	initially	initially	ADV
admet-733	257	5	identified	identify	VERB
admet-733	257	6	fragment	fragment	NOUN
admet-733	257	7	binder	binder	NOUN
admet-733	257	8	(	(	PUNCT
admet-733	257	9	compound	compound	NOUN
admet-733	257	10	1	1	NUM
admet-733	257	11	)	)	PUNCT
admet-733	257	12	and	and	CCONJ
admet-733	257	13	key	key	ADJ
admet-733	257	14	compounds	compound	NOUN
admet-733	257	15	(	(	PUNCT
admet-733	257	16	2	2	NUM
admet-733	257	17	–	–	SYM
admet-733	257	18	5	5	NUM
admet-733	257	19	)	)	PUNCT
admet-733	257	20	that	that	PRON
admet-733	257	21	were	be	AUX
admet-733	257	22	made	make	VERB
admet-733	257	23	in	in	ADP
admet-733	257	24	the	the	DET
admet-733	257	25	search	search	NOUN
admet-733	257	26	for	for	ADP
admet-733	257	27	a	a	DET
admet-733	257	28	cell	cell	NOUN
admet-733	257	29	active	active	ADJ
admet-733	257	30	compound	compound	NOUN
admet-733	257	31	to	to	PART
admet-733	257	32	probe	probe	VERB
admet-733	257	33	the	the	DET
admet-733	257	34	biology	biology	NOUN
admet-733	257	35	associated	associate	VERB
admet-733	257	36	with	with	ADP
admet-733	257	37	phgdh	phgdh	NOUN
admet-733	257	38	as	as	ADP
admet-733	257	39	a	a	DET
admet-733	257	40	drug	drug	NOUN
admet-733	257	41	target	target	NOUN
admet-733	257	42	.	.	PUNCT
admet-733	258	1	admet	admet	PROPN
admet-733	258	2	&	&	CCONJ
admet-733	258	3	dmpk	dmpk	PROPN
admet-733	258	4	7(4	7(4	NUM
admet-733	258	5	)	)	PUNCT
admet-733	258	6	(	(	PUNCT
admet-733	258	7	2019	2019	NUM
admet-733	258	8	)	)	PUNCT
admet-733	258	9	222	222	NUM
admet-733	258	10	-	-	PUNCT
admet-733	258	11	241	241	NUM
admet-733	258	12	biophysical	biophysical	ADJ
admet-733	258	13	methods	method	NOUN
admet-733	258	14	in	in	ADP
admet-733	258	15	early	early	ADJ
admet-733	258	16	drug	drug	NOUN
admet-733	258	17	discovery	discovery	NOUN
admet-733	258	18	doi	doi	PROPN
admet-733	258	19	:	:	PUNCT
admet-733	258	20	10.5599	10.5599	NUM
admet-733	258	21	/	/	SYM
admet-733	258	22	admet.733	admet.733	ADJ
admet-733	258	23	237	237	NUM
admet-733	258	24	figure	figure	NOUN
admet-733	258	25	7	7	NUM
admet-733	258	26	(	(	PUNCT
admet-733	258	27	a	a	X
admet-733	258	28	)	)	PUNCT
admet-733	258	29	itc	itc	PROPN
admet-733	258	30	titration	titration	NOUN
admet-733	258	31	data	datum	NOUN
admet-733	258	32	for	for	ADP
admet-733	258	33	the	the	DET
admet-733	258	34	binding	binding	NOUN
admet-733	258	35	of	of	ADP
admet-733	258	36	nadh	nadh	NOUN
admet-733	258	37	to	to	ADP
admet-733	258	38	full	full	ADJ
admet-733	258	39	length	length	NOUN
admet-733	258	40	phgdh	phgdh	NOUN
admet-733	258	41	,	,	PUNCT
admet-733	258	42	kd	kd	PROPN
admet-733	258	43	=	=	PROPN
admet-733	258	44	0.33	0.33	NUM
admet-733	258	45	±	±	NUM
admet-733	258	46	0.08	0.08	NUM
admet-733	258	47	µm	µm	NOUN
admet-733	258	48	,	,	PUNCT
admet-733	258	49	n	n	NOUN
admet-733	258	50	=	=	NUM
admet-733	258	51	0.78	0.78	NUM
admet-733	258	52	±	±	NUM
admet-733	258	53	0.01	0.01	NUM
admet-733	258	54	.	.	PUNCT
admet-733	259	1	(	(	PUNCT
admet-733	259	2	b	b	X
admet-733	259	3	)	)	PUNCT
admet-733	259	4	spr	spr	PROPN
admet-733	259	5	titration	titration	NOUN
admet-733	259	6	data	datum	NOUN
admet-733	259	7	for	for	ADP
admet-733	259	8	nadh	nadh	NOUN
admet-733	259	9	binding	bind	VERB
admet-733	259	10	to	to	ADP
admet-733	259	11	full	full	ADJ
admet-733	259	12	length	length	NOUN
admet-733	259	13	phgdh	phgdh	NOUN
admet-733	259	14	,	,	PUNCT
admet-733	259	15	kd	kd	PROPN
admet-733	259	16	=	=	PROPN
admet-733	259	17	0.4	0.4	NUM
admet-733	259	18	±	±	NUM
admet-733	259	19	0.03	0.03	NUM
admet-733	259	20	µm	µm	ADP
admet-733	259	21	determined	determine	VERB
admet-733	259	22	from	from	ADP
admet-733	259	23	a	a	DET
admet-733	259	24	steady	steady	ADJ
admet-733	259	25	state	state	NOUN
admet-733	259	26	fit	fit	NOUN
admet-733	259	27	,	,	PUNCT
admet-733	259	28	with	with	ADP
admet-733	259	29	the	the	DET
admet-733	259	30	kinetic	kinetic	ADJ
admet-733	259	31	fit	fit	ADJ
admet-733	259	32	curve	curve	NOUN
admet-733	259	33	shown	show	VERB
admet-733	259	34	in	in	ADP
admet-733	259	35	the	the	DET
admet-733	259	36	inset	inset	NOUN
admet-733	259	37	.	.	PUNCT
admet-733	260	1	(	(	PUNCT
admet-733	260	2	c	c	X
admet-733	260	3	)	)	PUNCT
admet-733	260	4	spr	spr	PROPN
admet-733	260	5	titration	titration	NOUN
admet-733	260	6	data	datum	NOUN
admet-733	260	7	for	for	ADP
admet-733	260	8	nadh	nadh	NOUN
admet-733	260	9	binding	bind	VERB
admet-733	260	10	to	to	ADP
admet-733	260	11	nad	nad	ADJ
admet-733	260	12	binding	bind	VERB
admet-733	260	13	domain	domain	NOUN
admet-733	260	14	of	of	ADP
admet-733	260	15	phgdh	phgdh	NOUN
admet-733	260	16	,	,	PUNCT
admet-733	260	17	kd	kd	PROPN
admet-733	260	18	=	=	PROPN
admet-733	260	19	6.7	6.7	NUM
admet-733	260	20	±	±	NUM
admet-733	260	21	0.5	0.5	NUM
admet-733	260	22	µm	µm	ADP
admet-733	260	23	determined	determine	VERB
admet-733	260	24	from	from	ADP
admet-733	260	25	a	a	DET
admet-733	260	26	steady	steady	ADJ
admet-733	260	27	state	state	NOUN
admet-733	260	28	fit	fit	NOUN
admet-733	260	29	,	,	PUNCT
admet-733	260	30	with	with	ADP
admet-733	260	31	the	the	DET
admet-733	260	32	kinetic	kinetic	ADJ
admet-733	260	33	fit	fit	ADJ
admet-733	260	34	curve	curve	NOUN
admet-733	260	35	shown	show	VERB
admet-733	260	36	in	in	ADP
admet-733	260	37	the	the	DET
admet-733	260	38	inset	inset	NOUN
admet-733	260	39	.	.	PUNCT
admet-733	261	1	case	case	NOUN
admet-733	261	2	study	study	VERB
admet-733	261	3	2	2	NUM
admet-733	261	4	biophysical	biophysical	ADJ
admet-733	261	5	characterisation	characterisation	NOUN
admet-733	261	6	of	of	ADP
admet-733	261	7	hits	hit	NOUN
admet-733	261	8	from	from	ADP
admet-733	261	9	dna	dna	PROPN
admet-733	261	10	encoded	encode	VERB
admet-733	261	11	library	library	NOUN
admet-733	261	12	(	(	PUNCT
admet-733	261	13	del	del	NOUN
admet-733	261	14	)	)	PUNCT
admet-733	261	15	screening	screen	VERB
admet-733	261	16	dna	dna	PROPN
admet-733	261	17	-	-	PUNCT
admet-733	261	18	encoded	encode	VERB
admet-733	261	19	library	library	NOUN
admet-733	261	20	(	(	PUNCT
admet-733	261	21	del	del	NOUN
admet-733	261	22	)	)	PUNCT
admet-733	261	23	technologies	technology	NOUN
admet-733	261	24	[	[	X
admet-733	261	25	40	40	NUM
admet-733	261	26	]	]	PUNCT
admet-733	261	27	offer	offer	VERB
admet-733	261	28	an	an	DET
admet-733	261	29	alternative	alternative	NOUN
admet-733	261	30	to	to	ADP
admet-733	261	31	traditional	traditional	ADJ
admet-733	261	32	high	high	ADJ
admet-733	261	33	-	-	PUNCT
admet-733	261	34	throughput	throughput	NOUN
admet-733	261	35	screening	screening	NOUN
admet-733	261	36	and	and	CCONJ
admet-733	261	37	have	have	VERB
admet-733	261	38	the	the	DET
admet-733	261	39	unique	unique	ADJ
admet-733	261	40	ability	ability	NOUN
admet-733	261	41	to	to	PART
admet-733	261	42	interrogate	interrogate	VERB
admet-733	261	43	very	very	ADV
admet-733	261	44	large	large	ADJ
admet-733	261	45	compound	compound	NOUN
admet-733	261	46	libraries	library	NOUN
admet-733	261	47	(	(	PUNCT
admet-733	261	48	of	of	ADP
admet-733	261	49	around	around	ADP
admet-733	261	50	109–1011	109–1011	NUM
admet-733	261	51	small	small	ADJ
admet-733	261	52	molecules	molecule	NOUN
admet-733	261	53	)	)	PUNCT
admet-733	261	54	.	.	PUNCT
admet-733	262	1	whereas	whereas	SCONJ
admet-733	262	2	traditional	traditional	ADJ
admet-733	262	3	hts	ht	NOUN
admet-733	262	4	methods	method	NOUN
admet-733	262	5	often	often	ADV
admet-733	262	6	rely	rely	VERB
admet-733	262	7	on	on	ADP
admet-733	262	8	activity	activity	NOUN
admet-733	262	9	-	-	PUNCT
admet-733	262	10	based	base	VERB
admet-733	262	11	isolated	isolated	ADJ
admet-733	262	12	protein	protein	NOUN
admet-733	262	13	or	or	CCONJ
admet-733	262	14	cellbased	cellbase	VERB
admet-733	262	15	assays	assay	NOUN
admet-733	262	16	,	,	PUNCT
admet-733	262	17	the	the	DET
admet-733	262	18	del	del	PROPN
admet-733	262	19	screening	screening	NOUN
admet-733	262	20	method	method	NOUN
admet-733	262	21	is	be	AUX
admet-733	262	22	based	base	VERB
admet-733	262	23	on	on	ADP
admet-733	262	24	affinity	affinity	NOUN
admet-733	262	25	selection	selection	NOUN
admet-733	262	26	versus	versus	ADP
admet-733	262	27	an	an	DET
admet-733	262	28	immobilised	immobilised	ADJ
admet-733	262	29	protein	protein	NOUN
admet-733	262	30	target	target	NOUN
admet-733	262	31	,	,	PUNCT
admet-733	262	32	is	be	AUX
admet-733	262	33	rapid	rapid	ADJ
admet-733	262	34	and	and	CCONJ
admet-733	262	35	requires	require	VERB
admet-733	262	36	only	only	ADV
admet-733	262	37	microgram	microgram	ADJ
admet-733	262	38	quantities	quantity	NOUN
admet-733	262	39	of	of	ADP
admet-733	262	40	protein	protein	NOUN
admet-733	262	41	.	.	PUNCT
admet-733	263	1	targets	target	NOUN
admet-733	263	2	can	can	AUX
admet-733	263	3	be	be	AUX
admet-733	263	4	screened	screen	VERB
admet-733	263	5	under	under	ADP
admet-733	263	6	multiple	multiple	ADJ
admet-733	263	7	different	different	ADJ
admet-733	263	8	experimental	experimental	ADJ
admet-733	263	9	conditions	condition	NOUN
admet-733	263	10	in	in	ADP
admet-733	263	11	parallel	parallel	NOUN
admet-733	263	12	.	.	PUNCT
admet-733	264	1	for	for	ADP
admet-733	264	2	example	example	NOUN
admet-733	264	3	,	,	PUNCT
admet-733	264	4	different	different	ADJ
admet-733	264	5	protein	protein	NOUN
admet-733	264	6	concentrations	concentration	NOUN
admet-733	264	7	,	,	PUNCT
admet-733	264	8	addition	addition	NOUN
admet-733	264	9	of	of	ADP
admet-733	264	10	different	different	ADJ
admet-733	264	11	cofactors	cofactor	NOUN
admet-733	264	12	or	or	CCONJ
admet-733	264	13	competing	compete	VERB
admet-733	264	14	inhibitors	inhibitor	NOUN
admet-733	264	15	,	,	PUNCT
admet-733	264	16	including	include	VERB
admet-733	264	17	proteins	protein	NOUN
admet-733	264	18	which	which	PRON
admet-733	264	19	represent	represent	VERB
admet-733	264	20	important	important	ADJ
admet-733	264	21	selectivity	selectivity	NOUN
admet-733	264	22	targets	target	NOUN
admet-733	264	23	could	could	AUX
admet-733	264	24	all	all	PRON
admet-733	264	25	represent	represent	VERB
admet-733	264	26	selection	selection	NOUN
admet-733	264	27	conditions	condition	NOUN
admet-733	264	28	that	that	PRON
admet-733	264	29	represent	represent	VERB
admet-733	264	30	useful	useful	ADJ
admet-733	264	31	ways	way	NOUN
admet-733	264	32	for	for	ADP
admet-733	264	33	identifying	identify	VERB
admet-733	264	34	novel	novel	NOUN
admet-733	264	35	start	start	NOUN
admet-733	264	36	points	point	NOUN
admet-733	264	37	,	,	PUNCT
admet-733	264	38	with	with	ADP
admet-733	264	39	potentially	potentially	ADV
admet-733	264	40	differentiated	differentiate	VERB
admet-733	264	41	modes	mode	NOUN
admet-733	264	42	of	of	ADP
admet-733	264	43	action	action	NOUN
admet-733	264	44	.	.	PUNCT
admet-733	265	1	in	in	ADP
admet-733	265	2	a	a	DET
admet-733	265	3	del	del	ADJ
admet-733	265	4	screen	screen	NOUN
admet-733	265	5	versus	versus	ADP
admet-733	265	6	the	the	DET
admet-733	265	7	acyl	acyl	NOUN
admet-733	265	8	carrier	carrier	NOUN
admet-733	265	9	protein	protein	NOUN
admet-733	265	10	enoyl	enoyl	NOUN
admet-733	265	11	reductase	reductase	NOUN
admet-733	265	12	inha	inha	NOUN
admet-733	265	13	,	,	PUNCT
admet-733	265	14	a	a	DET
admet-733	265	15	pool	pool	NOUN
admet-733	265	16	of	of	ADP
admet-733	265	17	11	11	NUM
admet-733	265	18	dna	dna	NOUN
admet-733	265	19	-	-	PUNCT
admet-733	265	20	encoded	encode	VERB
admet-733	265	21	libraries	library	NOUN
admet-733	265	22	consisting	consist	VERB
admet-733	265	23	of	of	ADP
admet-733	265	24	more	more	ADJ
admet-733	265	25	than	than	ADP
admet-733	265	26	65	65	NUM
admet-733	265	27	billion	billion	NUM
admet-733	265	28	on	on	ADP
admet-733	265	29	-	-	PUNCT
admet-733	265	30	dna	dna	NOUN
admet-733	265	31	compounds	compound	NOUN
admet-733	265	32	were	be	AUX
admet-733	265	33	tested	test	VERB
admet-733	265	34	and	and	CCONJ
admet-733	265	35	subsequent	subsequent	ADJ
admet-733	265	36	selections	selection	NOUN
admet-733	265	37	made	make	VERB
admet-733	265	38	utilising	utilise	VERB
admet-733	265	39	different	different	ADJ
admet-733	265	40	forms	form	NOUN
admet-733	265	41	of	of	ADP
admet-733	265	42	inha	inha	NOUN
admet-733	265	43	including	include	VERB
admet-733	265	44	the	the	DET
admet-733	265	45	apo	apo	PROPN
admet-733	265	46	protein	protein	NOUN
admet-733	265	47	,	,	PUNCT
admet-733	265	48	inha.nad+	inha.nad+	NOUN
admet-733	265	49	,	,	PUNCT
admet-733	265	50	and	and	CCONJ
admet-733	265	51	inha.nadh	inha.nadh	NOUN
admet-733	265	52	complexes	complex	NOUN
admet-733	265	53	.	.	PUNCT
admet-733	266	1	analysis	analysis	NOUN
admet-733	266	2	of	of	ADP
admet-733	266	3	output	output	NOUN
admet-733	266	4	highlighted	highlight	VERB
admet-733	266	5	four	four	NUM
admet-733	266	6	general	general	ADJ
admet-733	266	7	profiles	profile	NOUN
admet-733	266	8	of	of	ADP
admet-733	266	9	hits	hit	NOUN
admet-733	266	10	:	:	PUNCT
admet-733	266	11	(	(	PUNCT
admet-733	266	12	i	i	NOUN
admet-733	266	13	)	)	PUNCT
admet-733	266	14	enriched	enrich	VERB
admet-733	266	15	only	only	ADV
admet-733	266	16	versus	versus	ADP
admet-733	266	17	apo	apo	PROPN
admet-733	266	18	inha	inha	NOUN
admet-733	266	19	,	,	PUNCT
admet-733	266	20	(	(	PUNCT
admet-733	266	21	ii	ii	NOUN
admet-733	266	22	)	)	PUNCT
admet-733	266	23	enriched	enrich	VERB
admet-733	266	24	only	only	ADV
admet-733	266	25	versus	versus	ADP
admet-733	266	26	inha.nad+	inha.nad+	PUNCT
admet-733	266	27	complex	complex	ADJ
admet-733	266	28	,	,	PUNCT
admet-733	266	29	(	(	PUNCT
admet-733	266	30	iii	iii	NOUN
admet-733	266	31	)	)	PUNCT
admet-733	266	32	enriched	enrich	VERB
admet-733	266	33	only	only	ADV
admet-733	266	34	versus	versus	ADP
admet-733	266	35	inha	inha	NOUN
admet-733	266	36	:	:	PUNCT
admet-733	266	37	nadh	nadh	NOUN
admet-733	266	38	complex	complex	NOUN
admet-733	266	39	but	but	CCONJ
admet-733	266	40	not	not	PART
admet-733	266	41	in	in	ADP
admet-733	266	42	the	the	DET
admet-733	266	43	presence	presence	NOUN
admet-733	266	44	of	of	ADP
admet-733	266	45	an	an	DET
admet-733	266	46	added	add	VERB
admet-733	266	47	inhibitory	inhibitory	ADJ
admet-733	266	48	small	small	ADJ
admet-733	266	49	molecule	molecule	NOUN
admet-733	266	50	,	,	PUNCT
admet-733	266	51	and	and	CCONJ
admet-733	266	52	(	(	PUNCT
admet-733	266	53	iv	iv	X
admet-733	266	54	)	)	PUNCT
admet-733	266	55	enriched	enrich	VERB
admet-733	266	56	in	in	ADP
admet-733	266	57	the	the	DET
admet-733	266	58	presence	presence	NOUN
admet-733	266	59	of	of	ADP
admet-733	266	60	inha.nad+	inha.nad+	NOUN
admet-733	266	61	and	and	CCONJ
admet-733	266	62	inha.nadh	inha.nadh	NOUN
admet-733	266	63	but	but	CCONJ
admet-733	266	64	not	not	PART
admet-733	266	65	in	in	ADP
admet-733	266	66	the	the	DET
admet-733	266	67	presence	presence	NOUN
admet-733	266	68	of	of	ADP
admet-733	266	69	an	an	DET
admet-733	266	70	added	add	VERB
admet-733	266	71	inhibitory	inhibitory	ADJ
admet-733	266	72	small	small	ADJ
admet-733	266	73	molecule	molecule	NOUN
admet-733	266	74	.	.	PUNCT
admet-733	267	1	compounds	compound	NOUN
admet-733	267	2	,	,	PUNCT
admet-733	267	3	which	which	PRON
admet-733	267	4	were	be	AUX
admet-733	267	5	subsequently	subsequently	ADV
admet-733	267	6	synthesised	synthesise	VERB
admet-733	267	7	off	off	ADP
admet-733	267	8	-	-	PUNCT
admet-733	267	9	dna	dna	PROPN
admet-733	267	10	were	be	AUX
admet-733	267	11	tested	test	VERB
admet-733	267	12	in	in	ADP
admet-733	267	13	in	in	ADP
admet-733	267	14	vitro	vitro	X
admet-733	267	15	enzyme	enzyme	NOUN
admet-733	267	16	assays	assay	NOUN
admet-733	267	17	as	as	ADV
admet-733	267	18	well	well	ADV
admet-733	267	19	as	as	ADP
admet-733	267	20	profiled	profile	VERB
admet-733	267	21	biophysically	biophysically	ADV
admet-733	267	22	using	use	VERB
admet-733	267	23	spr	spr	PROPN
admet-733	267	24	.	.	PUNCT
admet-733	268	1	compounds	compound	NOUN
admet-733	268	2	were	be	AUX
admet-733	268	3	injected	inject	VERB
admet-733	268	4	either	either	CCONJ
admet-733	268	5	alone	alone	ADV
admet-733	268	6	,	,	PUNCT
admet-733	268	7	in	in	ADP
admet-733	268	8	the	the	DET
admet-733	268	9	presence	presence	NOUN
admet-733	268	10	of	of	ADP
admet-733	268	11	2	2	NUM
admet-733	268	12	mm	mm	PROPN
admet-733	268	13	nad+	nad+	NOUN
admet-733	268	14	,	,	PUNCT
admet-733	268	15	or	or	CCONJ
admet-733	268	16	in	in	ADP
admet-733	268	17	the	the	DET
admet-733	268	18	presence	presence	NOUN
admet-733	268	19	of	of	ADP
admet-733	268	20	100	100	NUM
admet-733	268	21	μm	μm	NOUN
admet-733	268	22	nadh	nadh	NOUN
admet-733	268	23	to	to	PART
admet-733	268	24	monitor	monitor	VERB
admet-733	268	25	binding	bind	VERB
admet-733	268	26	to	to	ADP
admet-733	268	27	different	different	ADJ
admet-733	268	28	forms	form	NOUN
admet-733	268	29	of	of	ADP
admet-733	268	30	the	the	DET
admet-733	268	31	protein	protein	NOUN
admet-733	268	32	.	.	PUNCT
admet-733	269	1	where	where	SCONJ
admet-733	269	2	required	require	VERB
admet-733	269	3	,	,	PUNCT
admet-733	269	4	excess	excess	ADJ
admet-733	269	5	cofactor	cofactor	NOUN
admet-733	269	6	was	be	AUX
admet-733	269	7	included	include	VERB
admet-733	269	8	in	in	ADP
admet-733	269	9	the	the	DET
admet-733	269	10	compound	compound	NOUN
admet-733	269	11	injections	injection	NOUN
admet-733	269	12	to	to	PART
admet-733	269	13	ensure	ensure	VERB
admet-733	269	14	that	that	SCONJ
admet-733	269	15	the	the	DET
admet-733	269	16	protein	protein	NOUN
admet-733	269	17	remained	remained	AUX
admet-733	269	18	saturated	saturate	VERB
admet-733	269	19	with	with	ADP
admet-733	269	20	cofactor	cofactor	NOUN
admet-733	269	21	.	.	PUNCT
admet-733	270	1	compounds	compound	NOUN
admet-733	270	2	selected	select	VERB
admet-733	270	3	from	from	ADP
admet-733	270	4	these	these	DET
admet-733	270	5	different	different	ADJ
admet-733	270	6	conditions	condition	NOUN
admet-733	270	7	could	could	AUX
admet-733	270	8	then	then	ADV
admet-733	270	9	be	be	AUX
admet-733	270	10	easily	easily	ADV
admet-733	270	11	profiled	profile	VERB
admet-733	270	12	against	against	ADP
admet-733	270	13	apo	apo	PROPN
admet-733	270	14	,	,	PUNCT
admet-733	270	15	nadh	nadh	NOUN
admet-733	270	16	or	or	CCONJ
admet-733	270	17	nad+-bound	nad+-bound	ADJ
admet-733	270	18	forms	form	NOUN
admet-733	270	19	of	of	ADP
admet-733	270	20	inha	inha	NOUN
admet-733	270	21	and	and	CCONJ
admet-733	270	22	their	their	PRON
admet-733	270	23	respective	respective	ADJ
admet-733	270	24	affinities	affinity	NOUN
admet-733	270	25	determined	determine	VERB
admet-733	270	26	from	from	ADP
admet-733	270	27	spr	spr	ADJ
admet-733	270	28	experiments	experiment	NOUN
admet-733	270	29	,	,	PUNCT
admet-733	270	30	table	table	NOUN
admet-733	270	31	5	5	NUM
admet-733	270	32	,	,	PUNCT
admet-733	270	33	allowing	allow	VERB
admet-733	270	34	potentially	potentially	ADV
admet-733	270	35	differentiated	differentiate	VERB
admet-733	270	36	profiles	profile	NOUN
admet-733	270	37	to	to	PART
admet-733	270	38	be	be	AUX
admet-733	270	39	investigated	investigate	VERB
admet-733	270	40	.	.	PUNCT
admet-733	271	1	the	the	DET
admet-733	271	2	del	del	PROPN
admet-733	271	3	technology	technology	NOUN
admet-733	271	4	allowed	allow	VERB
admet-733	271	5	the	the	DET
admet-733	271	6	identification	identification	NOUN
admet-733	271	7	of	of	ADP
admet-733	271	8	multiple	multiple	ADJ
admet-733	271	9	classes	class	NOUN
admet-733	271	10	of	of	ADP
admet-733	271	11	inha	inha	NOUN
admet-733	271	12	inhibitors	inhibitor	NOUN
admet-733	271	13	,	,	PUNCT
admet-733	271	14	some	some	PRON
admet-733	271	15	of	of	ADP
admet-733	271	16	which	which	PRON
admet-733	271	17	had	have	VERB
admet-733	271	18	cell	cell	NOUN
admet-733	271	19	-	-	PUNCT
admet-733	271	20	based	base	VERB
admet-733	271	21	activity	activity	NOUN
admet-733	271	22	directly	directly	ADV
admet-733	271	23	from	from	ADP
admet-733	271	24	the	the	DET
admet-733	271	25	primary	primary	ADJ
admet-733	271	26	screen	screen	NOUN
admet-733	271	27	.	.	PUNCT
admet-733	272	1	compounds	compound	NOUN
admet-733	272	2	were	be	AUX
admet-733	272	3	identified	identify	VERB
admet-733	272	4	as	as	ADP
admet-733	272	5	cofactor	cofactor	NOUN
admet-733	272	6	-	-	PUNCT
admet-733	272	7	specific	specific	ADJ
admet-733	272	8	binders	binder	NOUN
admet-733	272	9	of	of	ADP
admet-733	272	10	inha	inha	NOUN
admet-733	272	11	with	with	ADP
admet-733	272	12	often	often	ADV
admet-733	272	13	with	with	ADP
admet-733	272	14	higher	high	ADJ
admet-733	272	15	affinity	affinity	NOUN
admet-733	272	16	for	for	ADP
admet-733	272	17	the	the	DET
admet-733	272	18	nadh	nadh	NOUN
admet-733	272	19	bound	bind	VERB
admet-733	272	20	form	form	NOUN
admet-733	272	21	.	.	PUNCT
admet-733	273	1	compounds	compound	NOUN
admet-733	273	2	similar	similar	ADJ
admet-733	273	3	to	to	PART
admet-733	273	4	compound	compound	VERB
admet-733	273	5	7	7	NUM
admet-733	273	6	,	,	PUNCT
admet-733	273	7	figure	figure	NOUN
admet-733	273	8	8	8	NUM
admet-733	273	9	,	,	PUNCT
admet-733	273	10	were	be	AUX
admet-733	273	11	demonstrated	demonstrate	VERB
admet-733	273	12	to	to	PART
admet-733	273	13	inhibit	inhibit	VERB
admet-733	273	14	bacterial	bacterial	ADJ
admet-733	273	15	growth	growth	NOUN
admet-733	273	16	in	in	ADP
admet-733	273	17	mycobacterium	mycobacterium	NOUN
admet-733	273	18	tuberculosis	tuberculosis	NOUN
admet-733	273	19	minimum	minimum	ADJ
admet-733	273	20	inhibitory	inhibitory	ADJ
admet-733	273	21	concentration	concentration	NOUN
admet-733	273	22	(	(	PUNCT
admet-733	273	23	mic	mic	ADJ
admet-733	273	24	)	)	PUNCT
admet-733	273	25	assays	assay	NOUN
admet-733	273	26	and	and	CCONJ
admet-733	273	27	holdgate	holdgate	VERB
admet-733	273	28	et	et	PROPN
admet-733	273	29	al	al	PROPN
admet-733	273	30	.	.	PROPN
admet-733	273	31	admet	admet	PROPN
admet-733	273	32	&	&	CCONJ
admet-733	273	33	dmpk	dmpk	PROPN
admet-733	273	34	7(4	7(4	NUM
admet-733	273	35	)	)	PUNCT
admet-733	273	36	(	(	PUNCT
admet-733	273	37	2019	2019	NUM
admet-733	273	38	)	)	PUNCT
admet-733	273	39	222	222	NUM
admet-733	273	40	-	-	SYM
admet-733	273	41	241	241	NUM
admet-733	273	42	238	238	NUM
admet-733	273	43	to	to	PART
admet-733	273	44	kill	kill	VERB
admet-733	273	45	mycobacterium	mycobacterium	NOUN
admet-733	273	46	tuberculosis	tuberculosis	NOUN
admet-733	273	47	infected	infect	VERB
admet-733	273	48	human	human	ADJ
admet-733	273	49	thp-1	thp-1	PUNCT
admet-733	273	50	cells	cell	NOUN
admet-733	273	51	.	.	PUNCT
admet-733	274	1	table	table	NOUN
admet-733	274	2	5	5	NUM
admet-733	274	3	.	.	PUNCT
admet-733	274	4	example	example	NOUN
admet-733	274	5	of	of	ADP
admet-733	274	6	spr	spr	ADJ
admet-733	274	7	profiling	profiling	NOUN
admet-733	274	8	of	of	ADP
admet-733	274	9	del	del	PROPN
admet-733	274	10	screening	screening	NOUN
admet-733	274	11	hits	hit	NOUN
admet-733	275	1	compound	compound	NOUN
admet-733	275	2	kd	kd	PROPN
admet-733	275	3	µm	µm	ADP
admet-733	275	4	apo	apo	PROPN
admet-733	275	5	inha	inha	VERB
admet-733	275	6	inha.nad	inha.nad	NOUN
admet-733	275	7	+	+	CCONJ
admet-733	275	8	inha.nadh	inha.nadh	PROPN
admet-733	275	9	6	6	NUM
admet-733	275	10	>	>	SYM
admet-733	275	11	100	100	NUM
admet-733	275	12	13.4	13.4	NUM
admet-733	275	13	±	±	NUM
admet-733	275	14	4.3	4.3	NUM
admet-733	275	15	0.3	0.3	NUM
admet-733	275	16	±	±	NUM
admet-733	275	17	0.2	0.2	NUM
admet-733	275	18	7	7	NUM
admet-733	275	19	>	>	SYM
admet-733	275	20	100	100	NUM
admet-733	275	21	46.7	46.7	NUM
admet-733	275	22	±	±	NUM
admet-733	275	23	11.6	11.6	NUM
admet-733	275	24	0.09	0.09	NUM
admet-733	275	25	±	±	NUM
admet-733	275	26	0.06	0.06	NUM
admet-733	275	27	8	8	NUM
admet-733	275	28	>	>	SYM
admet-733	275	29	100	100	NUM
admet-733	275	30	>	>	SYM
admet-733	275	31	100	100	NUM
admet-733	275	32	0.3	0.3	NUM
admet-733	275	33	±	±	NUM
admet-733	275	34	0.1	0.1	NUM
admet-733	275	35	9	9	NUM
admet-733	275	36	>	>	ADP
admet-733	275	37	100	100	NUM
admet-733	275	38	>	>	SYM
admet-733	275	39	100	100	NUM
admet-733	275	40	36.8	36.8	NUM
admet-733	275	41	±	±	NUM
admet-733	275	42	3.3	3.3	NUM
admet-733	275	43	10	10	NUM
admet-733	275	44	>	>	SYM
admet-733	275	45	100	100	NUM
admet-733	275	46	49.0	49.0	NUM
admet-733	275	47	±	±	NUM
admet-733	275	48	2.9	2.9	NUM
admet-733	275	49	0.06	0.06	NUM
admet-733	275	50	±	±	NUM
admet-733	275	51	0.03	0.03	NUM
admet-733	275	52	11	11	NUM
admet-733	275	53	12.4	12.4	NUM
admet-733	275	54	±	±	NUM
admet-733	275	55	1.4	1.4	NUM
admet-733	275	56	0.3	0.3	NUM
admet-733	275	57	±	±	NUM
admet-733	275	58	0.1	0.1	NUM
admet-733	275	59	5.0	5.0	NUM
admet-733	275	60	±	±	NUM
admet-733	275	61	1.2	1.2	NUM
admet-733	275	62	12	12	NUM
admet-733	275	63	>	>	SYM
admet-733	275	64	100	100	NUM
admet-733	275	65	>	>	SYM
admet-733	275	66	100	100	NUM
admet-733	275	67	6.3	6.3	NUM
admet-733	275	68	±	±	NUM
admet-733	275	69	2.6	2.6	NUM
admet-733	275	70	s	s	NOUN
admet-733	275	71	o	o	PROPN
admet-733	275	72	n	n	CCONJ
admet-733	275	73	n	n	CCONJ
admet-733	275	74	n	n	CCONJ
admet-733	275	75	n	n	ADV
admet-733	275	76	o	o	NOUN
admet-733	275	77	o	o	X
admet-733	275	78	o	o	X
admet-733	275	79	n	n	CCONJ
admet-733	275	80	n	n	CCONJ
admet-733	275	81	n	n	CCONJ
admet-733	275	82	n	n	CCONJ
admet-733	275	83	n	n	ADV
admet-733	275	84	o	o	NOUN
admet-733	275	85	o	o	X
admet-733	275	86	o	o	X
admet-733	275	87	n	n	CCONJ
admet-733	275	88	n	n	CCONJ
admet-733	275	89	n	n	NOUN
admet-733	275	90	o	o	X
admet-733	275	91	f	f	PROPN
admet-733	275	92	n	n	CCONJ
admet-733	275	93	n	n	CCONJ
admet-733	275	94	n	n	NOUN
admet-733	275	95	o	o	NOUN
admet-733	275	96	n	n	CCONJ
admet-733	275	97	n	n	CCONJ
admet-733	275	98	n	n	CCONJ
admet-733	275	99	n	n	CCONJ
admet-733	275	100	n	n	CCONJ
admet-733	275	101	n	n	ADV
admet-733	275	102	o	o	NOUN
admet-733	275	103	o	o	X
admet-733	275	104	o	o	X
admet-733	275	105	n	n	CCONJ
admet-733	275	106	n	n	CCONJ
admet-733	275	107	n	n	CCONJ
admet-733	275	108	n	n	CCONJ
admet-733	275	109	n	n	CCONJ
admet-733	275	110	n	n	ADV
admet-733	275	111	o	o	NOUN
admet-733	276	1	o	o	X
admet-733	276	2	o	o	X
admet-733	276	3	o	o	X
admet-733	276	4	n	n	CCONJ
admet-733	276	5	n	n	CCONJ
admet-733	276	6	n	n	NOUN
admet-733	276	7	f	f	NOUN
admet-733	276	8	f	f	PROPN
admet-733	276	9	f	f	PROPN
admet-733	276	10	nn	nn	INTJ
admet-733	276	11	br	br	NOUN
admet-733	277	1	oo	oo	INTJ
admet-733	277	2	o	o	PROPN
admet-733	277	3	n	n	CCONJ
admet-733	277	4	n	n	CCONJ
admet-733	277	5	n	n	CCONJ
admet-733	277	6	n	n	ADV
admet-733	278	1	o	o	NOUN
admet-733	278	2	o	o	X
admet-733	278	3	o	o	X
admet-733	278	4	compound	compound	NOUN
admet-733	278	5	6	6	NUM
admet-733	278	6	compound	compound	NOUN
admet-733	278	7	7	7	NUM
admet-733	278	8	compound	compound	NOUN
admet-733	278	9	8	8	NUM
admet-733	278	10	compound	compound	NOUN
admet-733	278	11	9	9	NUM
admet-733	278	12	compound	compound	NOUN
admet-733	278	13	10	10	NUM
admet-733	278	14	compound	compound	NOUN
admet-733	278	15	11	11	NUM
admet-733	278	16	compound	compound	NOUN
admet-733	278	17	12	12	NUM
admet-733	278	18	figure	figure	NOUN
admet-733	278	19	8	8	NUM
admet-733	278	20	.	.	PUNCT
admet-733	279	1	compound	compound	NOUN
admet-733	279	2	structures	structure	NOUN
admet-733	279	3	identified	identify	VERB
admet-733	279	4	via	via	ADP
admet-733	279	5	del	del	NOUN
admet-733	279	6	screening	screening	NOUN
admet-733	279	7	and	and	CCONJ
admet-733	279	8	profiled	profile	VERB
admet-733	279	9	using	use	VERB
admet-733	280	1	spr	spr	PROPN
admet-733	280	2	.	.	PUNCT
admet-733	280	3	discussion	discussion	NOUN
admet-733	280	4	there	there	PRON
admet-733	280	5	are	be	VERB
admet-733	280	6	a	a	DET
admet-733	280	7	range	range	NOUN
admet-733	280	8	of	of	ADP
admet-733	280	9	biophysical	biophysical	ADJ
admet-733	280	10	methods	method	NOUN
admet-733	280	11	that	that	PRON
admet-733	280	12	are	be	AUX
admet-733	280	13	available	available	ADJ
admet-733	280	14	for	for	ADP
admet-733	280	15	application	application	NOUN
admet-733	280	16	at	at	ADP
admet-733	280	17	many	many	ADJ
admet-733	280	18	points	point	NOUN
admet-733	280	19	during	during	ADP
admet-733	280	20	early	early	ADJ
admet-733	280	21	drug	drug	NOUN
admet-733	280	22	discovery	discovery	NOUN
admet-733	280	23	.	.	PUNCT
admet-733	281	1	each	each	DET
admet-733	281	2	method	method	NOUN
admet-733	281	3	has	have	VERB
admet-733	281	4	its	its	PRON
admet-733	281	5	own	own	ADJ
admet-733	281	6	advantages	advantage	NOUN
admet-733	281	7	and	and	CCONJ
admet-733	281	8	disadvantages	disadvantage	NOUN
admet-733	281	9	that	that	PRON
admet-733	281	10	lead	lead	VERB
admet-733	281	11	to	to	ADP
admet-733	281	12	different	different	ADJ
admet-733	281	13	applications	application	NOUN
admet-733	281	14	dependent	dependent	ADJ
admet-733	281	15	upon	upon	SCONJ
admet-733	281	16	the	the	DET
admet-733	281	17	reagents	reagent	NOUN
admet-733	281	18	available	available	ADJ
admet-733	281	19	and	and	CCONJ
admet-733	281	20	the	the	DET
admet-733	281	21	information	information	NOUN
admet-733	281	22	content	content	NOUN
admet-733	281	23	desired	desire	VERB
admet-733	281	24	.	.	PUNCT
admet-733	282	1	for	for	ADP
admet-733	282	2	example	example	NOUN
admet-733	282	3	,	,	PUNCT
admet-733	282	4	asms	asm	NOUN
admet-733	282	5	is	be	AUX
admet-733	282	6	most	most	ADV
admet-733	282	7	suited	suited	ADJ
admet-733	282	8	to	to	ADP
admet-733	282	9	higher	high	ADJ
admet-733	282	10	throughput	throughput	NOUN
admet-733	282	11	screening	screening	NOUN
admet-733	282	12	,	,	PUNCT
admet-733	282	13	whereas	whereas	SCONJ
admet-733	282	14	spr	spr	PROPN
admet-733	282	15	is	be	AUX
admet-733	282	16	positioned	position	VERB
admet-733	282	17	to	to	PART
admet-733	282	18	deliver	deliver	VERB
admet-733	282	19	kinetic	kinetic	ADJ
admet-733	282	20	data	datum	NOUN
admet-733	282	21	.	.	PUNCT
admet-733	283	1	nmr	nmr	NOUN
admet-733	283	2	can	can	AUX
admet-733	283	3	provide	provide	VERB
admet-733	283	4	structural	structural	ADJ
admet-733	283	5	insights	insight	NOUN
admet-733	283	6	and	and	CCONJ
admet-733	283	7	is	be	AUX
admet-733	283	8	the	the	DET
admet-733	283	9	preferred	preferred	ADJ
admet-733	283	10	approach	approach	NOUN
admet-733	283	11	for	for	ADP
admet-733	283	12	primary	primary	ADJ
admet-733	283	13	fragment	fragment	NOUN
admet-733	283	14	screening	screening	NOUN
admet-733	283	15	and	and	CCONJ
admet-733	283	16	itc	itc	PROPN
admet-733	283	17	provides	provide	VERB
admet-733	283	18	a	a	DET
admet-733	283	19	rapid	rapid	ADJ
admet-733	283	20	thermodynamic	thermodynamic	ADJ
admet-733	283	21	characterisation	characterisation	NOUN
admet-733	283	22	of	of	ADP
admet-733	283	23	the	the	DET
admet-733	283	24	binding	bind	VERB
admet-733	283	25	event	event	NOUN
admet-733	283	26	.	.	PUNCT
admet-733	284	1	the	the	DET
admet-733	284	2	decision	decision	NOUN
admet-733	284	3	about	about	ADP
admet-733	284	4	which	which	DET
admet-733	284	5	method	method	NOUN
admet-733	284	6	or	or	CCONJ
admet-733	284	7	combination	combination	NOUN
admet-733	284	8	of	of	ADP
admet-733	284	9	methods	method	NOUN
admet-733	284	10	to	to	PART
admet-733	284	11	employ	employ	VERB
admet-733	284	12	can	can	AUX
admet-733	284	13	be	be	AUX
admet-733	284	14	complex	complex	ADJ
admet-733	284	15	and	and	CCONJ
admet-733	284	16	subject	subject	ADJ
admet-733	284	17	to	to	ADP
admet-733	284	18	change	change	NOUN
admet-733	284	19	depending	depend	VERB
admet-733	284	20	upon	upon	SCONJ
admet-733	284	21	particular	particular	ADJ
admet-733	284	22	projects	project	NOUN
admet-733	284	23	,	,	PUNCT
admet-733	284	24	even	even	ADV
admet-733	284	25	if	if	SCONJ
admet-733	284	26	they	they	PRON
admet-733	284	27	are	be	AUX
admet-733	284	28	following	follow	VERB
admet-733	284	29	similar	similar	ADJ
admet-733	284	30	hit	hit	VERB
admet-733	284	31	identification	identification	NOUN
admet-733	284	32	and	and	CCONJ
admet-733	284	33	lead	lead	NOUN
admet-733	284	34	generation	generation	NOUN
admet-733	284	35	processes	process	NOUN
admet-733	284	36	.	.	PUNCT
admet-733	285	1	the	the	DET
admet-733	285	2	choice	choice	NOUN
admet-733	285	3	should	should	AUX
admet-733	285	4	ultimate	ultimate	VERB
admet-733	285	5	focus	focus	NOUN
admet-733	285	6	on	on	ADP
admet-733	285	7	what	what	DET
admet-733	285	8	information	information	NOUN
admet-733	285	9	is	be	AUX
admet-733	285	10	required	require	VERB
admet-733	285	11	,	,	PUNCT
admet-733	285	12	the	the	DET
admet-733	285	13	numbers	number	NOUN
admet-733	285	14	of	of	ADP
admet-733	285	15	compounds	compound	NOUN
admet-733	285	16	required	require	VERB
admet-733	285	17	from	from	ADP
admet-733	285	18	which	which	PRON
admet-733	285	19	data	datum	NOUN
admet-733	285	20	needs	need	VERB
admet-733	285	21	to	to	PART
admet-733	285	22	be	be	AUX
admet-733	285	23	generated	generate	VERB
admet-733	285	24	to	to	PART
admet-733	285	25	provide	provide	VERB
admet-733	285	26	this	this	DET
admet-733	285	27	information	information	NOUN
admet-733	285	28	and	and	CCONJ
admet-733	285	29	the	the	DET
admet-733	285	30	timescale	timescale	NOUN
admet-733	285	31	required	require	VERB
admet-733	285	32	to	to	PART
admet-733	285	33	deliver	deliver	VERB
admet-733	285	34	this	this	DET
admet-733	285	35	data	datum	NOUN
admet-733	285	36	.	.	PUNCT
admet-733	286	1	of	of	ADP
admet-733	286	2	course	course	NOUN
admet-733	286	3	,	,	PUNCT
admet-733	286	4	consideration	consideration	NOUN
admet-733	286	5	of	of	ADP
admet-733	286	6	the	the	DET
admet-733	286	7	target	target	NOUN
admet-733	286	8	itself	itself	PRON
admet-733	286	9	and	and	CCONJ
admet-733	286	10	the	the	DET
admet-733	286	11	nature	nature	NOUN
admet-733	286	12	of	of	ADP
admet-733	286	13	the	the	DET
admet-733	286	14	binding	bind	VERB
admet-733	286	15	site(s	site(s	NOUN
admet-733	286	16	)	)	PUNCT
admet-733	286	17	being	be	AUX
admet-733	286	18	targeted	target	VERB
admet-733	286	19	may	may	AUX
admet-733	286	20	also	also	ADV
admet-733	286	21	influence	influence	VERB
admet-733	286	22	this	this	DET
admet-733	286	23	decision	decision	NOUN
admet-733	286	24	.	.	PUNCT
admet-733	287	1	ultimately	ultimately	ADV
admet-733	287	2	,	,	PUNCT
admet-733	287	3	practical	practical	ADJ
admet-733	287	4	limitations	limitation	NOUN
admet-733	287	5	around	around	ADP
admet-733	287	6	protein	protein	NOUN
admet-733	287	7	availability	availability	NOUN
admet-733	287	8	,	,	PUNCT
admet-733	287	9	and	and	CCONJ
admet-733	287	10	costs	cost	NOUN
admet-733	287	11	will	will	AUX
admet-733	287	12	also	also	ADV
admet-733	287	13	need	need	VERB
admet-733	287	14	to	to	PART
admet-733	287	15	be	be	AUX
admet-733	287	16	taken	take	VERB
admet-733	287	17	into	into	ADP
admet-733	287	18	account	account	NOUN
admet-733	287	19	.	.	PUNCT
admet-733	288	1	however	however	ADV
admet-733	288	2	,	,	PUNCT
admet-733	288	3	projects	project	NOUN
admet-733	288	4	often	often	ADV
admet-733	288	5	benefit	benefit	VERB
admet-733	288	6	from	from	ADP
admet-733	288	7	the	the	DET
admet-733	288	8	impact	impact	NOUN
admet-733	288	9	that	that	PRON
admet-733	288	10	a	a	DET
admet-733	288	11	combination	combination	NOUN
admet-733	288	12	of	of	ADP
admet-733	288	13	biophysical	biophysical	ADJ
admet-733	288	14	and	and	CCONJ
admet-733	288	15	biochemical	biochemical	ADJ
admet-733	288	16	assay	assay	NOUN
admet-733	288	17	derived	derive	VERB
admet-733	288	18	information	information	NOUN
admet-733	288	19	can	can	AUX
admet-733	288	20	provide	provide	VERB
admet-733	288	21	,	,	PUNCT
admet-733	288	22	and	and	CCONJ
admet-733	288	23	biophysical	biophysical	ADJ
admet-733	288	24	methods	method	NOUN
admet-733	288	25	should	should	AUX
admet-733	288	26	be	be	AUX
admet-733	288	27	an	an	DET
admet-733	288	28	integral	integral	ADJ
admet-733	288	29	part	part	NOUN
admet-733	288	30	of	of	ADP
admet-733	288	31	any	any	DET
admet-733	288	32	protein	protein	NOUN
admet-733	288	33	centric	centric	ADJ
admet-733	288	34	drug	drug	NOUN
admet-733	288	35	discovery	discovery	NOUN
admet-733	288	36	project	project	NOUN
admet-733	288	37	.	.	PUNCT
admet-733	289	1	admet	admet	PROPN
admet-733	289	2	&	&	CCONJ
admet-733	289	3	dmpk	dmpk	PROPN
admet-733	289	4	7(4	7(4	NUM
admet-733	289	5	)	)	PUNCT
admet-733	289	6	(	(	PUNCT
admet-733	289	7	2019	2019	NUM
admet-733	289	8	)	)	PUNCT
admet-733	289	9	222	222	NUM
admet-733	289	10	-	-	PUNCT
admet-733	289	11	241	241	NUM
admet-733	289	12	biophysical	biophysical	ADJ
admet-733	289	13	methods	method	NOUN
admet-733	289	14	in	in	ADP
admet-733	289	15	early	early	ADJ
admet-733	289	16	drug	drug	NOUN
admet-733	289	17	discovery	discovery	NOUN
admet-733	289	18	doi	doi	PROPN
admet-733	289	19	:	:	PUNCT
admet-733	289	20	10.5599	10.5599	NUM
admet-733	289	21	/	/	SYM
admet-733	289	22	admet.733	admet.733	ADJ
admet-733	289	23	239	239	NUM
admet-733	289	24	conclusions	conclusion	NOUN
admet-733	289	25	biophysical	biophysical	ADJ
admet-733	289	26	methods	method	NOUN
admet-733	289	27	have	have	AUX
admet-733	289	28	evolved	evolve	VERB
admet-733	289	29	from	from	ADP
admet-733	289	30	being	be	AUX
admet-733	289	31	employed	employ	VERB
admet-733	289	32	to	to	PART
admet-733	289	33	address	address	VERB
admet-733	289	34	isolated	isolated	ADJ
admet-733	289	35	issues	issue	NOUN
admet-733	289	36	with	with	ADP
admet-733	289	37	tool	tool	NOUN
admet-733	289	38	compounds	compound	NOUN
admet-733	289	39	or	or	CCONJ
admet-733	289	40	target	target	NOUN
admet-733	289	41	proteins	protein	NOUN
admet-733	289	42	,	,	PUNCT
admet-733	289	43	experienced	experience	VERB
admet-733	289	44	in	in	ADP
admet-733	289	45	some	some	DET
admet-733	289	46	early	early	ADJ
admet-733	289	47	stage	stage	NOUN
admet-733	289	48	projects	project	NOUN
admet-733	289	49	[	[	X
admet-733	289	50	41	41	NUM
admet-733	289	51	]	]	PUNCT
admet-733	289	52	,	,	PUNCT
admet-733	289	53	to	to	PART
admet-733	289	54	now	now	ADV
admet-733	289	55	being	be	AUX
admet-733	289	56	an	an	DET
admet-733	289	57	essential	essential	ADJ
admet-733	289	58	and	and	CCONJ
admet-733	289	59	integral	integral	ADJ
admet-733	289	60	part	part	NOUN
admet-733	289	61	of	of	ADP
admet-733	289	62	the	the	DET
admet-733	289	63	workflow	workflow	NOUN
admet-733	289	64	positioned	position	VERB
admet-733	289	65	to	to	PART
admet-733	289	66	establish	establish	VERB
admet-733	289	67	and	and	CCONJ
admet-733	289	68	pursue	pursue	VERB
admet-733	289	69	hit	hit	VERB
admet-733	289	70	identification	identification	NOUN
admet-733	289	71	and	and	CCONJ
admet-733	289	72	characterisation	characterisation	NOUN
admet-733	289	73	across	across	ADP
admet-733	289	74	the	the	DET
admet-733	289	75	whole	whole	ADJ
admet-733	289	76	portfolio	portfolio	NOUN
admet-733	289	77	.	.	PUNCT
admet-733	290	1	over	over	ADP
admet-733	290	2	the	the	DET
admet-733	290	3	last	last	ADJ
admet-733	290	4	5	5	NUM
admet-733	290	5	years	year	NOUN
admet-733	290	6	or	or	CCONJ
admet-733	290	7	so	so	ADV
admet-733	290	8	,	,	PUNCT
admet-733	290	9	this	this	DET
admet-733	290	10	progression	progression	NOUN
admet-733	290	11	has	have	AUX
admet-733	290	12	been	be	AUX
admet-733	290	13	driven	drive	VERB
admet-733	290	14	by	by	ADP
admet-733	290	15	the	the	DET
admet-733	290	16	impact	impact	NOUN
admet-733	290	17	these	these	DET
admet-733	290	18	methods	method	NOUN
admet-733	290	19	have	have	AUX
admet-733	290	20	had	have	VERB
admet-733	290	21	,	,	PUNCT
admet-733	290	22	an	an	DET
admet-733	290	23	increased	increase	VERB
admet-733	290	24	throughput	throughput	NOUN
admet-733	290	25	for	for	ADP
admet-733	290	26	some	some	DET
admet-733	290	27	methods	method	NOUN
admet-733	290	28	,	,	PUNCT
admet-733	290	29	and	and	CCONJ
admet-733	290	30	the	the	DET
admet-733	290	31	recognition	recognition	NOUN
admet-733	290	32	that	that	SCONJ
admet-733	290	33	a	a	DET
admet-733	290	34	better	well	ADJ
admet-733	290	35	understanding	understanding	NOUN
admet-733	290	36	of	of	ADP
admet-733	290	37	the	the	DET
admet-733	290	38	reagents	reagent	NOUN
admet-733	290	39	,	,	PUNCT
admet-733	290	40	tools	tool	NOUN
admet-733	290	41	,	,	PUNCT
admet-733	290	42	assays	assay	NOUN
admet-733	290	43	and	and	CCONJ
admet-733	290	44	that	that	SCONJ
admet-733	290	45	mechanistic	mechanistic	ADJ
admet-733	290	46	characterisation	characterisation	NOUN
admet-733	290	47	and	and	CCONJ
admet-733	290	48	differentiation	differentiation	NOUN
admet-733	290	49	of	of	ADP
admet-733	290	50	hits	hit	NOUN
admet-733	290	51	yields	yield	NOUN
admet-733	290	52	a	a	DET
admet-733	290	53	more	more	ADV
admet-733	290	54	efficient	efficient	ADJ
admet-733	290	55	early	early	ADJ
admet-733	290	56	stage	stage	NOUN
admet-733	290	57	drug	drug	NOUN
admet-733	290	58	discovery	discovery	NOUN
admet-733	290	59	process	process	NOUN
admet-733	290	60	.	.	PUNCT
admet-733	291	1	this	this	PRON
admet-733	291	2	has	have	AUX
admet-733	291	3	led	lead	VERB
admet-733	291	4	to	to	ADP
admet-733	291	5	a	a	DET
admet-733	291	6	more	more	ADV
admet-733	291	7	focussed	focussed	ADJ
admet-733	291	8	use	use	NOUN
admet-733	291	9	of	of	ADP
admet-733	291	10	biophysics	biophysic	NOUN
admet-733	291	11	alongside	alongside	ADP
admet-733	291	12	the	the	DET
admet-733	291	13	more	more	ADV
admet-733	291	14	traditional	traditional	ADJ
admet-733	291	15	approaches	approach	NOUN
admet-733	291	16	,	,	PUNCT
admet-733	291	17	such	such	ADJ
admet-733	291	18	as	as	ADP
admet-733	291	19	enzyme	enzyme	NOUN
admet-733	291	20	and	and	CCONJ
admet-733	291	21	cell	cell	NOUN
admet-733	291	22	-	-	PUNCT
admet-733	291	23	based	base	VERB
admet-733	291	24	assays	assay	NOUN
admet-733	291	25	,	,	PUNCT
admet-733	291	26	which	which	PRON
admet-733	291	27	has	have	AUX
admet-733	291	28	increased	increase	VERB
admet-733	291	29	the	the	DET
admet-733	291	30	quality	quality	NOUN
admet-733	291	31	of	of	ADP
admet-733	291	32	these	these	DET
admet-733	291	33	early	early	ADJ
admet-733	291	34	hit	hit	NOUN
admet-733	291	35	-	-	PUNCT
admet-733	291	36	finding	find	VERB
admet-733	291	37	assays	assay	NOUN
admet-733	291	38	.	.	PUNCT
admet-733	292	1	biophysical	biophysical	ADJ
admet-733	292	2	methods	method	NOUN
admet-733	292	3	also	also	ADV
admet-733	292	4	are	be	AUX
admet-733	292	5	increasingly	increasingly	ADV
admet-733	292	6	used	use	VERB
admet-733	292	7	as	as	ADP
admet-733	292	8	primary	primary	ADJ
admet-733	292	9	hit	hit	NOUN
admet-733	292	10	finding	finding	NOUN
admet-733	292	11	approaches	approach	NOUN
admet-733	292	12	,	,	PUNCT
admet-733	292	13	and	and	CCONJ
admet-733	292	14	no	no	ADV
admet-733	292	15	longer	long	ADV
admet-733	292	16	just	just	ADV
admet-733	292	17	for	for	ADP
admet-733	292	18	small	small	ADJ
admet-733	292	19	,	,	PUNCT
admet-733	292	20	fragment	fragment	NOUN
admet-733	292	21	-	-	PUNCT
admet-733	292	22	based	base	VERB
admet-733	292	23	screens	screen	NOUN
admet-733	292	24	,	,	PUNCT
admet-733	292	25	but	but	CCONJ
admet-733	292	26	also	also	ADV
admet-733	292	27	for	for	ADP
admet-733	292	28	screening	screen	VERB
admet-733	292	29	increasingly	increasingly	ADV
admet-733	292	30	large	large	ADJ
admet-733	292	31	compound	compound	NOUN
admet-733	292	32	libraries	library	NOUN
admet-733	292	33	.	.	PUNCT
admet-733	293	1	the	the	DET
admet-733	293	2	recognition	recognition	NOUN
admet-733	293	3	that	that	PRON
admet-733	293	4	compound	compound	VERB
admet-733	293	5	binding	bind	VERB
admet-733	293	6	,	,	PUNCT
admet-733	293	7	can	can	AUX
admet-733	293	8	be	be	AUX
admet-733	293	9	placed	place	VERB
admet-733	293	10	ahead	ahead	ADV
admet-733	293	11	of	of	ADP
admet-733	293	12	activity	activity	NOUN
admet-733	293	13	-	-	PUNCT
admet-733	293	14	based	base	VERB
admet-733	293	15	screening	screening	NOUN
admet-733	293	16	,	,	PUNCT
admet-733	293	17	in	in	ADP
admet-733	293	18	an	an	DET
admet-733	293	19	orthogonal	orthogonal	ADJ
admet-733	293	20	dyad	dyad	NOUN
admet-733	293	21	has	have	AUX
admet-733	293	22	been	be	AUX
admet-733	293	23	embraced	embrace	VERB
admet-733	293	24	by	by	ADP
admet-733	293	25	screening	screen	VERB
admet-733	293	26	groups	group	NOUN
admet-733	293	27	and	and	CCONJ
admet-733	293	28	it	it	PRON
admet-733	293	29	may	may	AUX
admet-733	293	30	be	be	AUX
admet-733	293	31	especially	especially	ADV
admet-733	293	32	useful	useful	ADJ
admet-733	293	33	for	for	ADP
admet-733	293	34	novel	novel	ADJ
admet-733	293	35	targets	target	NOUN
admet-733	293	36	,	,	PUNCT
admet-733	293	37	whose	whose	DET
admet-733	293	38	functional	functional	ADJ
admet-733	293	39	activity	activity	NOUN
admet-733	293	40	is	be	AUX
admet-733	293	41	unknown	unknown	ADJ
admet-733	293	42	or	or	CCONJ
admet-733	293	43	difficult	difficult	ADJ
admet-733	293	44	to	to	PART
admet-733	293	45	assay	assay	VERB
admet-733	293	46	.	.	PUNCT
admet-733	294	1	as	as	ADP
admet-733	294	2	a	a	DET
admet-733	294	3	result	result	NOUN
admet-733	294	4	,	,	PUNCT
admet-733	294	5	biophysical	biophysical	ADJ
admet-733	294	6	methods	method	NOUN
admet-733	294	7	will	will	AUX
admet-733	294	8	remain	remain	VERB
admet-733	294	9	a	a	DET
admet-733	294	10	key	key	ADJ
admet-733	294	11	facet	facet	NOUN
admet-733	294	12	for	for	ADP
admet-733	294	13	increasing	increase	VERB
admet-733	294	14	drug	drug	NOUN
admet-733	294	15	discovery	discovery	NOUN
admet-733	294	16	success	success	NOUN
admet-733	294	17	.	.	PUNCT
admet-733	295	1	conflict	conflict	NOUN
admet-733	295	2	of	of	ADP
admet-733	295	3	interest	interest	NOUN
admet-733	295	4	:	:	PUNCT
admet-733	295	5	the	the	DET
admet-733	295	6	authors	author	NOUN
admet-733	295	7	are	be	AUX
admet-733	295	8	all	all	PRON
admet-733	295	9	employees	employee	NOUN
admet-733	295	10	of	of	ADP
admet-733	295	11	astrazeneca	astrazeneca	PROPN
admet-733	295	12	pharmaceuticals	pharmaceutical	NOUN
admet-733	295	13	references	reference	NOUN
admet-733	295	14	[	[	X
admet-733	295	15	1	1	NUM
admet-733	295	16	]	]	PUNCT
admet-733	295	17	t.	t.	PROPN
admet-733	295	18	wiseman	wiseman	PROPN
admet-733	295	19	,	,	PUNCT
admet-733	295	20	s.	s.	PROPN
admet-733	295	21	williston	williston	PROPN
admet-733	295	22	,	,	PUNCT
admet-733	295	23	j.f	j.f	PROPN
admet-733	295	24	.	.	PROPN
admet-733	295	25	brandts	brandts	PROPN
admet-733	295	26	,	,	PUNCT
admet-733	295	27	l.n	l.n	PROPN
admet-733	295	28	.	.	PROPN
admet-733	295	29	lin	lin	PROPN
admet-733	295	30	.	.	PUNCT
admet-733	296	1	rapid	rapid	ADJ
admet-733	296	2	measurement	measurement	NOUN
admet-733	296	3	of	of	ADP
admet-733	296	4	binding	bind	VERB
admet-733	296	5	constants	constant	NOUN
admet-733	296	6	and	and	CCONJ
admet-733	296	7	heats	heat	NOUN
admet-733	296	8	of	of	ADP
admet-733	296	9	binding	bind	VERB
admet-733	296	10	using	use	VERB
admet-733	296	11	a	a	DET
admet-733	296	12	new	new	ADJ
admet-733	296	13	titration	titration	NOUN
admet-733	296	14	calorimeter	calorimeter	NOUN
admet-733	296	15	.	.	PUNCT
admet-733	297	1	anal	anal	PROPN
admet-733	297	2	.	.	PUNCT
admet-733	297	3	biochem	biochem	PROPN
admet-733	297	4	.	.	PUNCT
admet-733	298	1	179	179	NUM
admet-733	298	2	(	(	PUNCT
admet-733	298	3	1989	1989	NUM
admet-733	298	4	)	)	PUNCT
admet-733	298	5	131	131	NUM
admet-733	298	6	-	-	SYM
admet-733	298	7	137	137	NUM
admet-733	298	8	.	.	PUNCT
admet-733	299	1	[	[	X
admet-733	299	2	2	2	NUM
admet-733	299	3	]	]	X
admet-733	299	4	l.g	l.g	PROPN
admet-733	299	5	.	.	PROPN
admet-733	299	6	fägerstam	fägerstam	PROPN
admet-733	299	7	,	,	PUNCT
admet-733	299	8	a.	a.	NOUN
admet-733	299	9	frostell	frostell	PROPN
admet-733	299	10	,	,	PUNCT
admet-733	299	11	r.	r.	PROPN
admet-733	299	12	karlsson	karlsson	PROPN
admet-733	299	13	,	,	PUNCT
admet-733	299	14	m.	m.	NOUN
admet-733	299	15	kullman	kullman	PROPN
admet-733	299	16	,	,	PUNCT
admet-733	299	17	a.	a.	PROPN
admet-733	299	18	larsson	larsson	PROPN
admet-733	299	19	,	,	PUNCT
admet-733	299	20	m.	m.	NOUN
admet-733	299	21	malmqvist	malmqvist	PROPN
admet-733	299	22	,	,	PUNCT
admet-733	299	23	h.	h.	PROPN
admet-733	299	24	butt	butt	PROPN
admet-733	299	25	.	.	PUNCT
admet-733	300	1	detection	detection	NOUN
admet-733	300	2	of	of	ADP
admet-733	300	3	antigen	antigen	NOUN
admet-733	300	4	-	-	PUNCT
admet-733	300	5	antibody	antibody	NOUN
admet-733	300	6	interactions	interaction	NOUN
admet-733	300	7	by	by	ADP
admet-733	300	8	surface	surface	NOUN
admet-733	300	9	plasmon	plasmon	ADJ
admet-733	300	10	resonance	resonance	NOUN
admet-733	300	11	.	.	PUNCT
admet-733	301	1	application	application	NOUN
admet-733	301	2	to	to	ADP
admet-733	301	3	epitope	epitope	PROPN
admet-733	301	4	mapping	mapping	NOUN
admet-733	301	5	.	.	PUNCT
admet-733	302	1	j.	j.	PROPN
admet-733	302	2	mol	mol	PROPN
admet-733	302	3	.	.	PROPN
admet-733	302	4	recognit	recognit	PROPN
admet-733	302	5	.	.	PUNCT
admet-733	303	1	3	3	NUM
admet-733	303	2	(	(	PUNCT
admet-733	303	3	1990	1990	NUM
admet-733	303	4	)	)	PUNCT
admet-733	303	5	208	208	NUM
admet-733	303	6	-	-	SYM
admet-733	303	7	214	214	NUM
admet-733	303	8	.	.	PUNCT
admet-733	304	1	[	[	X
admet-733	304	2	3	3	X
admet-733	304	3	]	]	X
admet-733	304	4	r.n	r.n	PROPN
admet-733	304	5	.	.	PROPN
admet-733	304	6	zuckermann	zuckermann	PROPN
admet-733	304	7	,	,	PUNCT
admet-733	304	8	j.m	j.m	PROPN
admet-733	304	9	.	.	PROPN
admet-733	304	10	kerr	kerr	PROPN
admet-733	304	11	,	,	PUNCT
admet-733	304	12	m.a	m.a	PROPN
admet-733	304	13	.	.	PROPN
admet-733	304	14	siani	siani	PROPN
admet-733	304	15	,	,	PUNCT
admet-733	304	16	s.c	s.c	PROPN
admet-733	304	17	.	.	PROPN
admet-733	304	18	banville	banville	PROPN
admet-733	304	19	,	,	PUNCT
admet-733	304	20	d.v	d.v	PROPN
admet-733	304	21	.	.	PROPN
admet-733	304	22	santi	santi	PROPN
admet-733	304	23	.	.	PROPN
admet-733	304	24	identification	identification	NOUN
admet-733	304	25	of	of	ADP
admet-733	304	26	highest	high	ADJ
admet-733	304	27	-	-	PUNCT
admet-733	304	28	affinity	affinity	NOUN
admet-733	304	29	ligands	ligand	NOUN
admet-733	304	30	by	by	ADP
admet-733	304	31	affinity	affinity	NOUN
admet-733	304	32	selection	selection	NOUN
admet-733	304	33	from	from	ADP
admet-733	304	34	equimolar	equimolar	ADJ
admet-733	304	35	peptide	peptide	NOUN
admet-733	304	36	mixtures	mixture	NOUN
admet-733	304	37	generated	generate	VERB
admet-733	304	38	by	by	ADP
admet-733	304	39	robotic	robotic	ADJ
admet-733	304	40	synthesis	synthesis	NOUN
admet-733	304	41	.	.	PUNCT
admet-733	305	1	proc	proc	NOUN
admet-733	305	2	.	.	PUNCT
admet-733	306	1	natl	natl	PROPN
admet-733	306	2	.	.	PUNCT
admet-733	307	1	acad	acad	PROPN
admet-733	307	2	.	.	PUNCT
admet-733	308	1	sci	sci	PROPN
admet-733	308	2	.	.	PUNCT
admet-733	308	3	u.s.a	u.s.a	PROPN
admet-733	308	4	.	.	PROPN
admet-733	308	5	89	89	NUM
admet-733	308	6	(	(	PUNCT
admet-733	308	7	1992	1992	NUM
admet-733	308	8	)	)	PUNCT
admet-733	308	9	4505	4505	NUM
admet-733	308	10	-	-	SYM
admet-733	308	11	4509	4509	NUM
admet-733	308	12	.	.	PUNCT
admet-733	309	1	[	[	X
admet-733	309	2	4	4	NUM
admet-733	309	3	]	]	X
admet-733	309	4	s.b	s.b	PROPN
admet-733	309	5	.	.	PROPN
admet-733	309	6	shuker	shuker	PROPN
admet-733	309	7	,	,	PUNCT
admet-733	309	8	p.j	p.j	PROPN
admet-733	309	9	.	.	PROPN
admet-733	309	10	hajduk	hajduk	PROPN
admet-733	309	11	,	,	PUNCT
admet-733	309	12	r.p	r.p	PROPN
admet-733	309	13	.	.	PROPN
admet-733	309	14	meadows	meadow	NOUN
admet-733	309	15	,	,	PUNCT
admet-733	309	16	s.w	s.w	PROPN
admet-733	309	17	.	.	PROPN
admet-733	309	18	fesik	fesik	NOUN
admet-733	309	19	.	.	PUNCT
admet-733	310	1	discovering	discover	VERB
admet-733	310	2	high	high	ADJ
admet-733	310	3	-	-	PUNCT
admet-733	310	4	affinity	affinity	NOUN
admet-733	310	5	ligands	ligand	NOUN
admet-733	310	6	for	for	ADP
admet-733	310	7	proteins	protein	NOUN
admet-733	310	8	:	:	PUNCT
admet-733	310	9	sar	sar	NOUN
admet-733	310	10	by	by	ADP
admet-733	310	11	nmr	nmr	PROPN
admet-733	310	12	.	.	PUNCT
admet-733	311	1	science	science	NOUN
admet-733	311	2	274	274	NUM
admet-733	311	3	(	(	PUNCT
admet-733	311	4	1996	1996	NUM
admet-733	311	5	)	)	PUNCT
admet-733	311	6	1531	1531	NUM
admet-733	311	7	-	-	SYM
admet-733	311	8	1534	1534	NUM
admet-733	311	9	.	.	PUNCT
admet-733	312	1	[	[	X
admet-733	312	2	5	5	NUM
admet-733	312	3	]	]	X
admet-733	312	4	r.m	r.m	PROPN
admet-733	312	5	.	.	PROPN
admet-733	312	6	burch	burch	PROPN
admet-733	312	7	,	,	PUNCT
admet-733	312	8	d.j	d.j	PROPN
admet-733	312	9	.	.	PROPN
admet-733	312	10	kyle	kyle	PROPN
admet-733	312	11	.	.	PUNCT
admet-733	313	1	mass	mass	PROPN
admet-733	313	2	receptor	receptor	NOUN
admet-733	313	3	screening	screen	VERB
admet-733	313	4	for	for	ADP
admet-733	313	5	new	new	ADJ
admet-733	313	6	drugs	drug	NOUN
admet-733	313	7	.	.	PUNCT
admet-733	314	1	pharm	pharm	NOUN
admet-733	314	2	.	.	PUNCT
admet-733	315	1	res	re	NOUN
admet-733	315	2	.	.	PROPN
admet-733	315	3	8	8	NUM
admet-733	315	4	(	(	PUNCT
admet-733	315	5	1991	1991	NUM
admet-733	315	6	)	)	PUNCT
admet-733	315	7	141	141	NUM
admet-733	315	8	-	-	SYM
admet-733	315	9	147	147	NUM
admet-733	315	10	.	.	PUNCT
admet-733	316	1	[	[	X
admet-733	316	2	6	6	NUM
admet-733	316	3	]	]	X
admet-733	316	4	d.a	d.a	PROPN
admet-733	316	5	.	.	PROPN
admet-733	316	6	pereira	pereira	PROPN
admet-733	316	7	,	,	PUNCT
admet-733	316	8	j.a	j.a	PROPN
admet-733	316	9	.	.	PROPN
admet-733	316	10	williams	williams	PROPN
admet-733	316	11	.	.	PUNCT
admet-733	316	12	origin	origin	PROPN
admet-733	316	13	and	and	CCONJ
admet-733	316	14	evolution	evolution	NOUN
admet-733	316	15	of	of	ADP
admet-733	316	16	high	high	ADJ
admet-733	316	17	throughput	throughput	NOUN
admet-733	316	18	screening	screening	NOUN
admet-733	316	19	.	.	PUNCT
admet-733	317	1	br	br	X
admet-733	317	2	.	.	PUNCT
admet-733	318	1	j.	j.	PROPN
admet-733	318	2	pharmacol	pharmacol	PROPN
admet-733	318	3	.	.	PUNCT
admet-733	319	1	152	152	NUM
admet-733	319	2	(	(	PUNCT
admet-733	319	3	2007	2007	NUM
admet-733	319	4	)	)	PUNCT
admet-733	319	5	53	53	NUM
admet-733	319	6	-	-	SYM
admet-733	319	7	61	61	NUM
admet-733	319	8	.	.	PUNCT
admet-733	320	1	[	[	X
admet-733	320	2	7	7	X
admet-733	320	3	]	]	X
admet-733	320	4	j.r	j.r	PROPN
admet-733	320	5	.	.	PROPN
admet-733	320	6	miller	miller	PROPN
admet-733	320	7	,	,	PUNCT
admet-733	320	8	v.	v.	PROPN
admet-733	320	9	thanabal	thanabal	PROPN
admet-733	320	10	,	,	PUNCT
admet-733	320	11	m.m	m.m	PROPN
admet-733	320	12	.	.	PROPN
admet-733	320	13	melnick	melnick	PROPN
admet-733	320	14	,	,	PUNCT
admet-733	320	15	m.	m.	PROPN
admet-733	320	16	lall	lall	PROPN
admet-733	320	17	,	,	PUNCT
admet-733	320	18	c.	c.	PROPN
admet-733	320	19	donovan	donovan	PROPN
admet-733	320	20	,	,	PUNCT
admet-733	320	21	r.w	r.w	PROPN
admet-733	320	22	.	.	PROPN
admet-733	320	23	sarver	sarver	PROPN
admet-733	320	24	,	,	PUNCT
admet-733	320	25	d.y	d.y	PROPN
admet-733	320	26	.	.	PROPN
admet-733	320	27	lee	lee	PROPN
admet-733	320	28	,	,	PUNCT
admet-733	320	29	j.	j.	PROPN
admet-733	320	30	ohren	ohren	PROPN
admet-733	320	31	,	,	PUNCT
admet-733	320	32	d.	d.	PROPN
admet-733	320	33	emerson	emerson	PROPN
admet-733	320	34	.	.	PUNCT
admet-733	321	1	the	the	DET
admet-733	321	2	use	use	NOUN
admet-733	321	3	of	of	ADP
admet-733	321	4	biochemical	biochemical	ADJ
admet-733	321	5	and	and	CCONJ
admet-733	321	6	biophysical	biophysical	ADJ
admet-733	321	7	tools	tool	NOUN
admet-733	321	8	for	for	ADP
admet-733	321	9	triage	triage	NOUN
admet-733	321	10	of	of	ADP
admet-733	321	11	high	high	ADJ
admet-733	321	12	-	-	PUNCT
admet-733	321	13	throughput	throughput	NOUN
admet-733	321	14	screening	screening	NOUN
admet-733	321	15	hits	hit	VERB
admet-733	321	16	a	a	DET
admet-733	321	17	case	case	NOUN
admet-733	321	18	study	study	NOUN
admet-733	321	19	with	with	ADP
admet-733	321	20	escherichia	escherichia	NOUN
admet-733	321	21	coli	coli	NOUN
admet-733	321	22	phosphopantetheine	phosphopantetheine	NOUN
admet-733	321	23	adenylyltransferase	adenylyltransferase	PROPN
admet-733	321	24	.	.	PUNCT
admet-733	322	1	chem	chem	NOUN
admet-733	322	2	.	.	PUNCT
admet-733	323	1	biol	biol	PROPN
admet-733	323	2	.	.	PUNCT
admet-733	324	1	drug	drug	NOUN
admet-733	324	2	.	.	PUNCT
admet-733	325	1	des	des	PROPN
admet-733	325	2	.	.	PROPN
admet-733	325	3	75	75	NUM
admet-733	325	4	(	(	PUNCT
admet-733	325	5	2010	2010	NUM
admet-733	325	6	)	)	PUNCT
admet-733	325	7	444	444	NUM
admet-733	325	8	-	-	SYM
admet-733	325	9	454	454	NUM
admet-733	325	10	.	.	PUNCT
admet-733	326	1	[	[	X
admet-733	326	2	8	8	NUM
admet-733	326	3	]	]	X
admet-733	326	4	s.j	s.j	PROPN
admet-733	326	5	.	.	PROPN
admet-733	326	6	pfaff	pfaff	PROPN
admet-733	326	7	,	,	PUNCT
admet-733	326	8	m.s	m.s	PROPN
admet-733	326	9	.	.	PROPN
admet-733	326	10	chimenti	chimenti	PROPN
admet-733	326	11	,	,	PUNCT
admet-733	326	12	m.j	m.j	PROPN
admet-733	326	13	.	.	PROPN
admet-733	326	14	kelly	kelly	PROPN
admet-733	326	15	,	,	PUNCT
admet-733	326	16	m.r	m.r	PROPN
admet-733	326	17	.	.	PROPN
admet-733	326	18	arkin	arkin	PROPN
admet-733	326	19	.	.	PUNCT
admet-733	327	1	biophysical	biophysical	ADJ
admet-733	327	2	methods	method	NOUN
admet-733	327	3	for	for	ADP
admet-733	327	4	identifying	identify	VERB
admet-733	327	5	fragment	fragment	NOUN
admet-733	327	6	-	-	PUNCT
admet-733	327	7	based	base	VERB
admet-733	327	8	inhibitors	inhibitor	NOUN
admet-733	327	9	of	of	ADP
admet-733	327	10	protein	protein	NOUN
admet-733	327	11	-	-	PUNCT
admet-733	327	12	protein	protein	NOUN
admet-733	327	13	interactions	interaction	NOUN
admet-733	327	14	.	.	PUNCT
admet-733	328	1	methods	method	NOUN
admet-733	328	2	mol	mol	PROPN
admet-733	328	3	.	.	PUNCT
admet-733	329	1	biol	biol	PROPN
admet-733	329	2	.	.	PUNCT
admet-733	330	1	1278	1278	NUM
admet-733	330	2	(	(	PUNCT
admet-733	330	3	2015	2015	NUM
admet-733	330	4	)	)	PUNCT
admet-733	330	5	587	587	NUM
admet-733	330	6	-	-	SYM
admet-733	330	7	613	613	NUM
admet-733	330	8	.	.	PUNCT
admet-733	331	1	[	[	X
admet-733	331	2	9	9	NUM
admet-733	331	3	]	]	X
admet-733	331	4	t.n	t.n	PROPN
admet-733	331	5	.	.	PROPN
admet-733	331	6	o'connell	o'connell	PROPN
admet-733	331	7	,	,	PUNCT
admet-733	331	8	j.	j.	PROPN
admet-733	331	9	ramsay	ramsay	PROPN
admet-733	331	10	,	,	PUNCT
admet-733	331	11	s.f	s.f	PROPN
admet-733	331	12	.	.	PROPN
admet-733	331	13	rieth	rieth	PROPN
admet-733	331	14	,	,	PUNCT
admet-733	331	15	m.j	m.j	PROPN
admet-733	331	16	.	.	PROPN
admet-733	331	17	shapiro	shapiro	PROPN
admet-733	331	18	,	,	PUNCT
admet-733	331	19	j.g	j.g	PROPN
admet-733	331	20	.	.	PROPN
admet-733	331	21	stroh	stroh	PROPN
admet-733	331	22	.	.	PUNCT
admet-733	331	23	solution	solution	NOUN
admet-733	331	24	-	-	PUNCT
admet-733	331	25	based	base	VERB
admet-733	331	26	indirect	indirect	ADJ
admet-733	331	27	affinity	affinity	NOUN
admet-733	331	28	selection	selection	NOUN
admet-733	331	29	mass	mass	NOUN
admet-733	331	30	spectrometry	spectrometry	NOUN
admet-733	331	31	--	--	PUNCT
admet-733	331	32	a	a	DET
admet-733	331	33	general	general	ADJ
admet-733	331	34	tool	tool	NOUN
admet-733	331	35	for	for	ADP
admet-733	331	36	high	high	ADJ
admet-733	331	37	-	-	PUNCT
admet-733	331	38	throughput	throughput	NOUN
admet-733	331	39	screening	screening	NOUN
admet-733	331	40	of	of	ADP
admet-733	331	41	pharmaceutical	pharmaceutical	ADJ
admet-733	331	42	compound	compound	NOUN
admet-733	331	43	libraries	library	NOUN
admet-733	331	44	.	.	PUNCT
admet-733	332	1	anal	anal	ADJ
admet-733	332	2	.	.	PUNCT
admet-733	332	3	chem	chem	PROPN
admet-733	332	4	.	.	PUNCT
admet-733	333	1	86	86	NUM
admet-733	333	2	(	(	PUNCT
admet-733	333	3	2014	2014	NUM
admet-733	333	4	)	)	PUNCT
admet-733	333	5	7413	7413	NUM
admet-733	333	6	-	-	SYM
admet-733	333	7	7420	7420	NUM
admet-733	333	8	.	.	PUNCT
admet-733	334	1	[	[	X
admet-733	334	2	10	10	NUM
admet-733	334	3	]	]	X
admet-733	334	4	p.j	p.j	PROPN
admet-733	334	5	.	.	PROPN
admet-733	334	6	tonge	tonge	PROPN
admet-733	334	7	.	.	PUNCT
admet-733	334	8	drug	drug	NOUN
admet-733	334	9	-	-	PUNCT
admet-733	334	10	target	target	NOUN
admet-733	334	11	kinetics	kinetic	NOUN
admet-733	334	12	in	in	ADP
admet-733	334	13	drug	drug	NOUN
admet-733	334	14	discovery	discovery	NOUN
admet-733	334	15	.	.	PUNCT
admet-733	335	1	acs	acs	PROPN
admet-733	335	2	chem	chem	PROPN
admet-733	335	3	.	.	PUNCT
admet-733	336	1	neurosci	neurosci	PROPN
admet-733	336	2	.	.	PUNCT
admet-733	337	1	9	9	NUM
admet-733	337	2	(	(	PUNCT
admet-733	337	3	2018	2018	NUM
admet-733	337	4	)	)	PUNCT
admet-733	337	5	29	29	NUM
admet-733	337	6	-	-	SYM
admet-733	337	7	39	39	NUM
admet-733	337	8	.	.	PUNCT
admet-733	338	1	[	[	X
admet-733	338	2	11	11	NUM
admet-733	338	3	]	]	X
admet-733	338	4	g.	g.	NOUN
admet-733	338	5	klebe	klebe	PROPN
admet-733	338	6	.	.	PUNCT
admet-733	339	1	applying	apply	VERB
admet-733	339	2	thermodynamic	thermodynamic	ADJ
admet-733	339	3	profiling	profiling	NOUN
admet-733	339	4	in	in	ADP
admet-733	339	5	lead	lead	NOUN
admet-733	339	6	finding	finding	NOUN
admet-733	339	7	and	and	CCONJ
admet-733	339	8	optimization	optimization	NOUN
admet-733	339	9	.	.	PUNCT
admet-733	340	1	nat	nat	PROPN
admet-733	340	2	.	.	PUNCT
admet-733	341	1	rev	rev	PROPN
admet-733	341	2	.	.	PROPN
admet-733	341	3	drug	drug	PROPN
admet-733	341	4	.	.	PUNCT
admet-733	342	1	discov	discov	NOUN
admet-733	342	2	.	.	PUNCT
admet-733	343	1	14	14	NUM
admet-733	343	2	(	(	PUNCT
admet-733	343	3	2015	2015	NUM
admet-733	343	4	)	)	PUNCT
admet-733	343	5	95	95	NUM
admet-733	343	6	-	-	SYM
admet-733	343	7	110	110	NUM
admet-733	343	8	.	.	PUNCT
admet-733	344	1	[	[	X
admet-733	344	2	12	12	NUM
admet-733	344	3	]	]	X
admet-733	344	4	m.g	m.g	PROPN
admet-733	344	5	.	.	PROPN
admet-733	344	6	carneiro	carneiro	PROPN
admet-733	344	7	,	,	PUNCT
admet-733	344	8	e.	e.	PROPN
admet-733	344	9	ab	ab	PROPN
admet-733	344	10	,	,	PUNCT
admet-733	344	11	s.	s.	PROPN
admet-733	344	12	theisgen	theisgen	PROPN
admet-733	344	13	,	,	PUNCT
admet-733	344	14	g.	g.	PROPN
admet-733	344	15	siegal	siegal	PROPN
admet-733	344	16	.	.	PUNCT
admet-733	345	1	nmr	nmr	NOUN
admet-733	345	2	in	in	ADP
admet-733	345	3	structure	structure	NOUN
admet-733	345	4	-	-	PUNCT
admet-733	345	5	based	base	VERB
admet-733	345	6	drug	drug	NOUN
admet-733	345	7	design	design	NOUN
admet-733	345	8	.	.	PUNCT
admet-733	346	1	essays	essays	PROPN
admet-733	346	2	biochem	biochem	PROPN
admet-733	346	3	.	.	PUNCT
admet-733	347	1	61	61	NUM
admet-733	347	2	(	(	PUNCT
admet-733	347	3	2017	2017	NUM
admet-733	347	4	)	)	PUNCT
admet-733	347	5	485	485	NUM
admet-733	347	6	-	-	SYM
admet-733	347	7	493	493	NUM
admet-733	347	8	.	.	PUNCT
admet-733	348	1	holdgate	holdgate	VERB
admet-733	348	2	et	et	PROPN
admet-733	348	3	al	al	PROPN
admet-733	348	4	.	.	PROPN
admet-733	348	5	admet	admet	PROPN
admet-733	348	6	&	&	CCONJ
admet-733	348	7	dmpk	dmpk	PROPN
admet-733	348	8	7(4	7(4	NUM
admet-733	348	9	)	)	PUNCT
admet-733	348	10	(	(	PUNCT
admet-733	348	11	2019	2019	NUM
admet-733	348	12	)	)	PUNCT
admet-733	348	13	222	222	NUM
admet-733	348	14	-	-	SYM
admet-733	348	15	241	241	NUM
admet-733	348	16	240	240	NUM
admet-733	348	17	[	[	X
admet-733	348	18	13	13	NUM
admet-733	348	19	]	]	X
admet-733	348	20	g.r	g.r	PROPN
admet-733	348	21	.	.	PROPN
admet-733	348	22	masson	masson	PROPN
admet-733	348	23	,	,	PUNCT
admet-733	348	24	m.l	m.l	PROPN
admet-733	348	25	.	.	PROPN
admet-733	348	26	jenkins	jenkins	PROPN
admet-733	348	27	,	,	PUNCT
admet-733	348	28	j.e	j.e	PROPN
admet-733	348	29	.	.	PROPN
admet-733	348	30	burke	burke	PROPN
admet-733	348	31	.	.	PUNCT
admet-733	349	1	an	an	DET
admet-733	349	2	overview	overview	NOUN
admet-733	349	3	of	of	ADP
admet-733	349	4	hydrogen	hydrogen	PROPN
admet-733	349	5	deuterium	deuterium	PROPN
admet-733	349	6	exchange	exchange	PROPN
admet-733	349	7	mass	mass	PROPN
admet-733	349	8	spectrometry	spectrometry	NOUN
admet-733	349	9	(	(	PUNCT
admet-733	349	10	hdx	hdx	NOUN
admet-733	349	11	-	-	PUNCT
admet-733	349	12	ms	ms	NOUN
admet-733	349	13	)	)	PUNCT
admet-733	349	14	in	in	ADP
admet-733	349	15	drug	drug	NOUN
admet-733	349	16	discovery	discovery	NOUN
admet-733	349	17	.	.	PUNCT
admet-733	350	1	expert	expert	NOUN
admet-733	350	2	opin	opin	NOUN
admet-733	350	3	.	.	PUNCT
admet-733	351	1	drug	drug	NOUN
admet-733	351	2	discov	discov	NOUN
admet-733	351	3	.	.	PUNCT
admet-733	352	1	12	12	NUM
admet-733	352	2	(	(	PUNCT
admet-733	352	3	2017	2017	NUM
admet-733	352	4	)	)	PUNCT
admet-733	352	5	981	981	NUM
admet-733	352	6	-	-	SYM
admet-733	352	7	994	994	NUM
admet-733	352	8	.	.	PUNCT
admet-733	353	1	[	[	X
admet-733	353	2	14	14	NUM
admet-733	353	3	]	]	SYM
admet-733	353	4	j.baell	j.baell	PROPN
admet-733	353	5	,	,	PUNCT
admet-733	353	6	m.	m.	NOUN
admet-733	353	7	a.	a.	PROPN
admet-733	353	8	walters	walters	PROPN
admet-733	353	9	.	.	PUNCT
admet-733	354	1	chemical	chemical	ADJ
admet-733	354	2	con	con	PROPN
admet-733	354	3	artists	artist	NOUN
admet-733	354	4	foil	foil	NOUN
admet-733	354	5	drug	drug	NOUN
admet-733	354	6	discovery	discovery	NOUN
admet-733	354	7	.	.	PUNCT
admet-733	355	1	nature	nature	NOUN
admet-733	355	2	513	513	NUM
admet-733	355	3	(	(	PUNCT
admet-733	355	4	2014	2014	NUM
admet-733	355	5	)	)	PUNCT
admet-733	355	6	481	481	NUM
admet-733	355	7	-	-	SYM
admet-733	355	8	483	483	NUM
admet-733	355	9	.	.	PUNCT
admet-733	356	1	[	[	X
admet-733	356	2	15	15	NUM
admet-733	356	3	]	]	X
admet-733	356	4	m.w	m.w	PROPN
admet-733	356	5	.	.	PROPN
admet-733	356	6	pantoliano	pantoliano	PROPN
admet-733	356	7	,	,	PUNCT
admet-733	356	8	e.c	e.c	PROPN
admet-733	356	9	.	.	PROPN
admet-733	356	10	petrella	petrella	PROPN
admet-733	356	11	,	,	PUNCT
admet-733	356	12	j.d	j.d	PROPN
admet-733	356	13	.	.	PROPN
admet-733	356	14	kwasnoski	kwasnoski	PROPN
admet-733	356	15	,	,	PUNCT
admet-733	356	16	v.s.	v.s.	ADJ
admet-733	356	17	lobanov	lobanov	PROPN
admet-733	356	18	,	,	PUNCT
admet-733	356	19	j.	j.	PROPN
admet-733	356	20	myslik	myslik	PROPN
admet-733	356	21	,	,	PUNCT
admet-733	356	22	e.	e.	PROPN
admet-733	356	23	graf	graf	PROPN
admet-733	356	24	,	,	PUNCT
admet-733	356	25	t.	t.	PROPN
admet-733	356	26	carver	carver	PROPN
admet-733	356	27	,	,	PUNCT
admet-733	356	28	e.	e.	PROPN
admet-733	356	29	asel	asel	PROPN
admet-733	356	30	,	,	PUNCT
admet-733	356	31	b.a	b.a	PROPN
admet-733	356	32	.	.	PROPN
admet-733	356	33	springer	springer	PROPN
admet-733	356	34	,	,	PUNCT
admet-733	356	35	p.	p.	PROPN
admet-733	356	36	lane	lane	PROPN
admet-733	356	37	,	,	PUNCT
admet-733	356	38	f.r	f.r	PROPN
admet-733	356	39	.	.	PROPN
admet-733	356	40	salemme	salemme	PROPN
admet-733	356	41	.	.	PUNCT
admet-733	357	1	high	high	ADJ
admet-733	357	2	-	-	PUNCT
admet-733	357	3	density	density	NOUN
admet-733	357	4	miniaturized	miniaturize	VERB
admet-733	357	5	thermal	thermal	ADJ
admet-733	357	6	shift	shift	NOUN
admet-733	357	7	assays	assay	NOUN
admet-733	357	8	as	as	ADP
admet-733	357	9	a	a	DET
admet-733	357	10	general	general	ADJ
admet-733	357	11	strategy	strategy	NOUN
admet-733	357	12	for	for	ADP
admet-733	357	13	drug	drug	NOUN
admet-733	357	14	discovery	discovery	NOUN
admet-733	357	15	.	.	PUNCT
admet-733	358	1	j.	j.	PROPN
admet-733	358	2	biomol	biomol	PROPN
admet-733	358	3	.	.	PUNCT
admet-733	359	1	screen	screen	NOUN
admet-733	359	2	.	.	PUNCT
admet-733	360	1	6	6	NUM
admet-733	360	2	(	(	PUNCT
admet-733	360	3	2001	2001	NUM
admet-733	360	4	)	)	PUNCT
admet-733	360	5	429	429	NUM
admet-733	360	6	-	-	SYM
admet-733	360	7	440	440	NUM
admet-733	360	8	.	.	PUNCT
admet-733	361	1	[	[	X
admet-733	361	2	16	16	NUM
admet-733	361	3	]	]	X
admet-733	361	4	t.n	t.n	PROPN
admet-733	361	5	.	.	PROPN
admet-733	361	6	o'connell	o'connell	PROPN
admet-733	361	7	,	,	PUNCT
admet-733	361	8	j.	j.	PROPN
admet-733	361	9	ramsay	ramsay	PROPN
admet-733	361	10	,	,	PUNCT
admet-733	361	11	s.f	s.f	PROPN
admet-733	361	12	.	.	PROPN
admet-733	361	13	rieth	rieth	PROPN
admet-733	361	14	,	,	PUNCT
admet-733	361	15	m.j	m.j	PROPN
admet-733	361	16	.	.	PROPN
admet-733	361	17	shapiro	shapiro	PROPN
admet-733	361	18	,	,	PUNCT
admet-733	361	19	j.g	j.g	PROPN
admet-733	361	20	.	.	PROPN
admet-733	361	21	stroh	stroh	PROPN
admet-733	361	22	.	.	PUNCT
admet-733	362	1	solution	solution	NOUN
admet-733	362	2	-	-	PUNCT
admet-733	362	3	based	base	VERB
admet-733	362	4	indirect	indirect	ADJ
admet-733	362	5	affinity	affinity	NOUN
admet-733	362	6	selection	selection	NOUN
admet-733	362	7	mass	mass	NOUN
admet-733	362	8	spectrometry	spectrometry	NOUN
admet-733	362	9	--	--	PUNCT
admet-733	362	10	a	a	DET
admet-733	362	11	general	general	ADJ
admet-733	362	12	tool	tool	NOUN
admet-733	362	13	for	for	ADP
admet-733	362	14	high	high	ADJ
admet-733	362	15	-	-	PUNCT
admet-733	362	16	throughput	throughput	NOUN
admet-733	362	17	screening	screening	NOUN
admet-733	362	18	of	of	ADP
admet-733	362	19	pharmaceutical	pharmaceutical	ADJ
admet-733	362	20	compound	compound	NOUN
admet-733	362	21	libraries	library	NOUN
admet-733	362	22	.	.	PUNCT
admet-733	363	1	anal	anal	ADJ
admet-733	363	2	.	.	PUNCT
admet-733	363	3	chem	chem	PROPN
admet-733	363	4	.	.	PUNCT
admet-733	364	1	86	86	NUM
admet-733	364	2	(	(	PUNCT
admet-733	364	3	2014	2014	NUM
admet-733	364	4	)	)	PUNCT
admet-733	364	5	7413	7413	NUM
admet-733	364	6	-	-	SYM
admet-733	364	7	7420	7420	NUM
admet-733	364	8	.	.	PUNCT
admet-733	365	1	[	[	X
admet-733	365	2	17	17	NUM
admet-733	365	3	]	]	X
admet-733	365	4	b.	b.	PROPN
admet-733	365	5	lamoree	lamoree	PROPN
admet-733	365	6	,	,	PUNCT
admet-733	365	7	r.e	r.e	PROPN
admet-733	365	8	.	.	PROPN
admet-733	365	9	hubbard	hubbard	PROPN
admet-733	365	10	.	.	PUNCT
admet-733	366	1	current	current	ADJ
admet-733	366	2	perspectives	perspective	NOUN
admet-733	366	3	in	in	ADP
admet-733	366	4	fragment	fragment	NOUN
admet-733	366	5	-	-	PUNCT
admet-733	366	6	based	base	VERB
admet-733	366	7	lead	lead	NOUN
admet-733	366	8	discovery	discovery	NOUN
admet-733	366	9	(	(	PUNCT
admet-733	366	10	fbld	fbld	NOUN
admet-733	366	11	)	)	PUNCT
admet-733	366	12	.	.	PUNCT
admet-733	367	1	essays	essays	PROPN
admet-733	367	2	biochem	biochem	PROPN
admet-733	367	3	.	.	PUNCT
admet-733	368	1	61	61	NUM
admet-733	368	2	(	(	PUNCT
admet-733	368	3	2017	2017	NUM
admet-733	368	4	)	)	PUNCT
admet-733	368	5	453	453	NUM
admet-733	368	6	-	-	SYM
admet-733	368	7	464	464	NUM
admet-733	368	8	.	.	PUNCT
admet-733	369	1	[	[	X
admet-733	369	2	18	18	NUM
admet-733	369	3	]	]	X
admet-733	369	4	i.	i.	PROPN
admet-733	369	5	navratilova	navratilova	PROPN
admet-733	369	6	,	,	PUNCT
admet-733	369	7	a.l	a.l	PROPN
admet-733	369	8	.	.	PROPN
admet-733	369	9	hopkins	hopkins	PROPN
admet-733	369	10	.	.	PUNCT
admet-733	370	1	fragment	fragment	NOUN
admet-733	370	2	screening	screening	NOUN
admet-733	370	3	by	by	ADP
admet-733	370	4	surface	surface	NOUN
admet-733	370	5	plasmon	plasmon	ADJ
admet-733	370	6	resonance	resonance	NOUN
admet-733	370	7	.	.	PUNCT
admet-733	371	1	acs	acs	PROPN
admet-733	371	2	med	med	PROPN
admet-733	371	3	.	.	PUNCT
admet-733	371	4	chem	chem	PROPN
admet-733	371	5	.	.	PUNCT
admet-733	372	1	lett	lett	PROPN
admet-733	372	2	.	.	PROPN
admet-733	373	1	1	1	NUM
admet-733	373	2	(	(	PUNCT
admet-733	373	3	2010	2010	NUM
admet-733	373	4	)	)	PUNCT
admet-733	373	5	44	44	NUM
admet-733	373	6	-	-	SYM
admet-733	373	7	48	48	NUM
admet-733	373	8	.	.	PUNCT
admet-733	374	1	[	[	X
admet-733	374	2	19	19	NUM
admet-733	374	3	]	]	X
admet-733	374	4	j.k	j.k	PROPN
admet-733	374	5	.	.	PROPN
admet-733	374	6	kranz	kranz	PROPN
admet-733	374	7	,	,	PUNCT
admet-733	374	8	c.	c.	PROPN
admet-733	374	9	schalk	schalk	PROPN
admet-733	374	10	-	-	PUNCT
admet-733	374	11	hihi	hihi	PROPN
admet-733	374	12	.	.	PUNCT
admet-733	375	1	protein	protein	NOUN
admet-733	375	2	thermal	thermal	ADJ
admet-733	375	3	shifts	shift	NOUN
admet-733	375	4	to	to	PART
admet-733	375	5	identify	identify	VERB
admet-733	375	6	low	low	ADJ
admet-733	375	7	molecular	molecular	ADJ
admet-733	375	8	weight	weight	NOUN
admet-733	375	9	fragments	fragment	NOUN
admet-733	375	10	.	.	PUNCT
admet-733	376	1	meth	meth	NOUN
admet-733	376	2	.	.	PUNCT
admet-733	377	1	enzymol	enzymol	PROPN
admet-733	377	2	.	.	PROPN
admet-733	378	1	493	493	NUM
admet-733	378	2	(	(	PUNCT
admet-733	378	3	2011	2011	NUM
admet-733	378	4	)	)	PUNCT
admet-733	378	5	277	277	NUM
admet-733	378	6	-	-	SYM
admet-733	378	7	298	298	NUM
admet-733	378	8	.	.	PUNCT
admet-733	379	1	[	[	X
admet-733	379	2	20	20	NUM
admet-733	379	3	]	]	X
admet-733	379	4	r.b	r.b	PROPN
admet-733	379	5	.	.	PROPN
admet-733	379	6	van	van	PROPN
admet-733	379	7	breemen	breemen	PROPN
admet-733	379	8	,	,	PUNCT
admet-733	379	9	c.r	c.r	PROPN
admet-733	379	10	.	.	PROPN
admet-733	379	11	huang	huang	PROPN
admet-733	379	12	,	,	PUNCT
admet-733	379	13	d.	d.	PROPN
admet-733	379	14	nikolic	nikolic	PROPN
admet-733	379	15	,	,	PUNCT
admet-733	379	16	c.p	c.p	PROPN
admet-733	379	17	.	.	PROPN
admet-733	379	18	woodbury	woodbury	PROPN
admet-733	379	19	,	,	PUNCT
admet-733	379	20	y.z	y.z	PROPN
admet-733	379	21	.	.	PROPN
admet-733	379	22	zhao	zhao	PROPN
admet-733	379	23	,	,	PUNCT
admet-733	379	24	d.l	d.l	PROPN
admet-733	379	25	.	.	PROPN
admet-733	379	26	venton	venton	PROPN
admet-733	379	27	.	.	PUNCT
admet-733	380	1	pulsed	pulse	VERB
admet-733	380	2	ultrafiltration	ultrafiltration	NOUN
admet-733	380	3	mass	mass	NOUN
admet-733	380	4	spectrometry	spectrometry	NOUN
admet-733	380	5	:	:	PUNCT
admet-733	380	6	a	a	DET
admet-733	380	7	new	new	ADJ
admet-733	380	8	method	method	NOUN
admet-733	380	9	for	for	ADP
admet-733	380	10	screening	screen	VERB
admet-733	380	11	combinatorial	combinatorial	ADJ
admet-733	380	12	libraries	library	NOUN
admet-733	380	13	.	.	PUNCT
admet-733	381	1	anal	anal	ADJ
admet-733	381	2	.	.	PUNCT
admet-733	381	3	chem	chem	PROPN
admet-733	381	4	.	.	PUNCT
admet-733	382	1	69	69	NUM
admet-733	382	2	(	(	PUNCT
admet-733	382	3	1997	1997	NUM
admet-733	382	4	)	)	PUNCT
admet-733	382	5	21592164	21592164	NUM
admet-733	382	6	.	.	PUNCT
admet-733	383	1	[	[	X
admet-733	383	2	21	21	NUM
admet-733	383	3	]	]	X
admet-733	383	4	t.n	t.n	PROPN
admet-733	383	5	.	.	PROPN
admet-733	383	6	o'connell	o'connell	PROPN
admet-733	383	7	,	,	PUNCT
admet-733	383	8	j.	j.	PROPN
admet-733	383	9	ramsay	ramsay	PROPN
admet-733	383	10	,	,	PUNCT
admet-733	383	11	s.f	s.f	PROPN
admet-733	383	12	.	.	PROPN
admet-733	383	13	rieth	rieth	PROPN
admet-733	383	14	,	,	PUNCT
admet-733	383	15	m.j	m.j	PROPN
admet-733	383	16	.	.	PROPN
admet-733	383	17	shapiro	shapiro	PROPN
admet-733	383	18	,	,	PUNCT
admet-733	383	19	j.g	j.g	PROPN
admet-733	383	20	.	.	PROPN
admet-733	383	21	stroh	stroh	PROPN
admet-733	383	22	.	.	PUNCT
admet-733	384	1	solution	solution	NOUN
admet-733	384	2	-	-	PUNCT
admet-733	384	3	based	base	VERB
admet-733	384	4	indirect	indirect	ADJ
admet-733	384	5	affinity	affinity	NOUN
admet-733	384	6	selection	selection	NOUN
admet-733	384	7	mass	mass	NOUN
admet-733	384	8	spectrometry	spectrometry	NOUN
admet-733	384	9	--	--	PUNCT
admet-733	384	10	a	a	DET
admet-733	384	11	general	general	ADJ
admet-733	384	12	tool	tool	NOUN
admet-733	384	13	for	for	ADP
admet-733	384	14	high	high	ADJ
admet-733	384	15	-	-	PUNCT
admet-733	384	16	throughput	throughput	NOUN
admet-733	384	17	screening	screening	NOUN
admet-733	384	18	of	of	ADP
admet-733	384	19	pharmaceutical	pharmaceutical	ADJ
admet-733	384	20	compound	compound	NOUN
admet-733	384	21	libraries	library	NOUN
admet-733	384	22	.	.	PUNCT
admet-733	385	1	anal	anal	ADJ
admet-733	385	2	.	.	PUNCT
admet-733	385	3	chem	chem	PROPN
admet-733	385	4	.	.	PUNCT
admet-733	386	1	86	86	NUM
admet-733	386	2	(	(	PUNCT
admet-733	386	3	2014	2014	NUM
admet-733	386	4	)	)	PUNCT
admet-733	386	5	7413	7413	NUM
admet-733	386	6	-	-	SYM
admet-733	386	7	7420	7420	NUM
admet-733	386	8	.	.	PUNCT
admet-733	387	1	[	[	X
admet-733	387	2	22	22	NUM
admet-733	387	3	]	]	PUNCT
admet-733	387	4	i.	i.	PROPN
admet-733	387	5	sinclair	sinclair	PROPN
admet-733	387	6	,	,	PUNCT
admet-733	387	7	m.	m.	NOUN
admet-733	387	8	bachman	bachman	PROPN
admet-733	387	9	,	,	PUNCT
admet-733	387	10	d.	d.	PROPN
admet-733	387	11	addison	addison	PROPN
admet-733	387	12	,	,	PUNCT
admet-733	387	13	m.	m.	NOUN
admet-733	387	14	rohman	rohman	PROPN
admet-733	387	15	,	,	PUNCT
admet-733	387	16	d.c	d.c	PROPN
admet-733	387	17	.	.	PROPN
admet-733	387	18	murray	murray	PROPN
admet-733	387	19	,	,	PUNCT
admet-733	387	20	g.	g.	PROPN
admet-733	387	21	davies	davies	PROPN
admet-733	387	22	,	,	PUNCT
admet-733	387	23	e.	e.	PROPN
admet-733	387	24	mouchet	mouchet	PROPN
admet-733	387	25	,	,	PUNCT
admet-733	387	26	m.e	m.e	PROPN
admet-733	387	27	.	.	PROPN
admet-733	387	28	tonge	tonge	PROPN
admet-733	387	29	,	,	PUNCT
admet-733	387	30	r.g	r.g	PROPN
admet-733	387	31	.	.	PROPN
admet-733	387	32	stearns	stearns	PROPN
admet-733	387	33	,	,	PUNCT
admet-733	387	34	l.	l.	PROPN
admet-733	387	35	ghislain	ghislain	PROPN
admet-733	387	36	,	,	PUNCT
admet-733	387	37	s.s	s.s	PROPN
admet-733	387	38	.	.	PROPN
admet-733	387	39	datwani	datwani	PROPN
admet-733	387	40	,	,	PUNCT
admet-733	387	41	l.	l.	PROPN
admet-733	387	42	majlof	majlof	PROPN
admet-733	387	43	,	,	PUNCT
admet-733	387	44	e.	e.	PROPN
admet-733	387	45	hall	hall	PROPN
admet-733	387	46	,	,	PUNCT
admet-733	387	47	g.r	g.r	PROPN
admet-733	387	48	.	.	PROPN
admet-733	387	49	jones	jones	PROPN
admet-733	387	50	,	,	PUNCT
admet-733	387	51	e.	e.	PROPN
admet-733	387	52	hoyes	hoyes	PROPN
admet-733	387	53	,	,	PUNCT
admet-733	387	54	j.	j.	PROPN
admet-733	387	55	olechno	olechno	PROPN
admet-733	387	56	,	,	PUNCT
admet-733	387	57	r.n	r.n	PROPN
admet-733	387	58	.	.	PROPN
admet-733	387	59	ellson	ellson	PROPN
admet-733	387	60	,	,	PUNCT
admet-733	387	61	p.e	p.e	PROPN
admet-733	387	62	.	.	PROPN
admet-733	387	63	barran	barran	PROPN
admet-733	387	64	,	,	PUNCT
admet-733	387	65	s.d	s.d	PROPN
admet-733	387	66	.	.	PROPN
admet-733	387	67	pringle	pringle	PROPN
admet-733	387	68	,	,	PUNCT
admet-733	387	69	m.r	m.r	PROPN
admet-733	387	70	.	.	PROPN
admet-733	387	71	morris	morris	PROPN
admet-733	387	72	,	,	PUNCT
admet-733	387	73	j.	j.	PROPN
admet-733	387	74	wingfield	wingfield	PROPN
admet-733	387	75	.	.	PUNCT
admet-733	388	1	acoustic	acoustic	ADJ
admet-733	388	2	mist	mist	NOUN
admet-733	388	3	ionization	ionization	NOUN
admet-733	388	4	platform	platform	NOUN
admet-733	388	5	for	for	ADP
admet-733	388	6	direct	direct	ADJ
admet-733	388	7	and	and	CCONJ
admet-733	388	8	contactless	contactless	ADJ
admet-733	388	9	ultrahigh	ultrahigh	NOUN
admet-733	388	10	-	-	PUNCT
admet-733	388	11	throughput	throughput	NOUN
admet-733	388	12	mass	mass	ADJ
admet-733	388	13	spectrometry	spectrometry	NOUN
admet-733	388	14	analysis	analysis	NOUN
admet-733	388	15	of	of	ADP
admet-733	388	16	liquid	liquid	ADJ
admet-733	388	17	samples	sample	NOUN
admet-733	388	18	.	.	PUNCT
admet-733	389	1	anal	anal	ADJ
admet-733	389	2	.	.	PUNCT
admet-733	389	3	chem	chem	PROPN
admet-733	389	4	.	.	PUNCT
admet-733	390	1	91	91	NUM
admet-733	390	2	(	(	PUNCT
admet-733	390	3	2019	2019	NUM
admet-733	390	4	)	)	PUNCT
admet-733	390	5	3790	3790	NUM
admet-733	390	6	-	-	SYM
admet-733	390	7	3794	3794	NUM
admet-733	390	8	.	.	PUNCT
admet-733	391	1	[	[	X
admet-733	391	2	23	23	NUM
admet-733	391	3	]	]	X
admet-733	391	4	t.e	t.e	PROPN
admet-733	391	5	.	.	PROPN
admet-733	391	6	carver	carver	PROPN
admet-733	391	7	,	,	PUNCT
admet-733	391	8	b.	b.	PROPN
admet-733	391	9	bordeau	bordeau	PROPN
admet-733	391	10	,	,	PUNCT
admet-733	391	11	m.d	m.d	PROPN
admet-733	391	12	.	.	PROPN
admet-733	391	13	cummings	cummings	PROPN
admet-733	391	14	,	,	PUNCT
admet-733	391	15	e.c	e.c	PROPN
admet-733	391	16	.	.	PROPN
admet-733	391	17	petrella	petrella	PROPN
admet-733	391	18	,	,	PUNCT
admet-733	391	19	m.j	m.j	PROPN
admet-733	391	20	.	.	PROPN
admet-733	391	21	pucci	pucci	PROPN
admet-733	391	22	,	,	PUNCT
admet-733	391	23	l.e	l.e	PROPN
admet-733	391	24	.	.	PROPN
admet-733	391	25	zawadzke	zawadzke	PROPN
admet-733	391	26	,	,	PUNCT
admet-733	391	27	b.a	b.a	PROPN
admet-733	391	28	.	.	PROPN
admet-733	391	29	dougherty	dougherty	PROPN
admet-733	391	30	,	,	PUNCT
admet-733	391	31	j.a	j.a	PROPN
admet-733	391	32	.	.	PROPN
admet-733	391	33	tredup	tredup	PROPN
admet-733	391	34	,	,	PUNCT
admet-733	391	35	j.w	j.w	PROPN
admet-733	391	36	.	.	PROPN
admet-733	391	37	bryson	bryson	PROPN
admet-733	391	38	,	,	PUNCT
admet-733	391	39	j.	j.	PROPN
admet-733	391	40	yanchunas	yanchunas	PROPN
admet-733	391	41	,	,	PUNCT
admet-733	391	42	m.l	m.l	PROPN
admet-733	391	43	.	.	PROPN
admet-733	391	44	doyle	doyle	PROPN
admet-733	391	45	,	,	PUNCT
admet-733	391	46	m.r	m.r	PROPN
admet-733	391	47	.	.	PROPN
admet-733	391	48	witmer	witmer	PROPN
admet-733	391	49	,	,	PUNCT
admet-733	391	50	m.i	m.i	PROPN
admet-733	391	51	.	.	PROPN
admet-733	391	52	nelen	nelen	PROPN
admet-733	391	53	,	,	PUNCT
admet-733	391	54	r.l	r.l	PROPN
admet-733	391	55	.	.	PROPN
admet-733	391	56	desjarlais	desjarlais	PROPN
admet-733	391	57	,	,	PUNCT
admet-733	391	58	e.p	e.p	PROPN
admet-733	391	59	.	.	PROPN
admet-733	391	60	jaeger	jaeger	PROPN
admet-733	391	61	,	,	PUNCT
admet-733	391	62	h.	h.	PROPN
admet-733	391	63	devine	devine	PROPN
admet-733	391	64	,	,	PUNCT
admet-733	391	65	e.d	e.d	PROPN
admet-733	391	66	.	.	PROPN
admet-733	391	67	asel	asel	PROPN
admet-733	391	68	,	,	PUNCT
admet-733	391	69	b.a	b.a	PROPN
admet-733	391	70	.	.	PROPN
admet-733	391	71	springer	springer	PROPN
admet-733	391	72	,	,	PUNCT
admet-733	391	73	r.	r.	PROPN
admet-733	391	74	bone	bone	PROPN
admet-733	391	75	,	,	PUNCT
admet-733	391	76	f.r	f.r	PROPN
admet-733	391	77	.	.	PROPN
admet-733	391	78	salemme	salemme	PROPN
admet-733	391	79	,	,	PUNCT
admet-733	391	80	m.j	m.j	PROPN
admet-733	391	81	.	.	PROPN
admet-733	391	82	todd	todd	PROPN
admet-733	391	83	.	.	PUNCT
admet-733	392	1	decrypting	decrypt	VERB
admet-733	392	2	the	the	DET
admet-733	392	3	biochemical	biochemical	ADJ
admet-733	392	4	function	function	NOUN
admet-733	392	5	of	of	ADP
admet-733	392	6	an	an	DET
admet-733	392	7	essential	essential	ADJ
admet-733	392	8	gene	gene	NOUN
admet-733	392	9	from	from	ADP
admet-733	392	10	streptococcus	streptococcus	NOUN
admet-733	392	11	pneumoniae	pneumoniae	ADJ
admet-733	392	12	using	use	VERB
admet-733	392	13	thermofluor	thermofluor	NOUN
admet-733	392	14	technology	technology	NOUN
admet-733	392	15	.	.	PUNCT
admet-733	393	1	j.	j.	PROPN
admet-733	393	2	biol	biol	PROPN
admet-733	393	3	.	.	PUNCT
admet-733	394	1	chem	chem	PROPN
admet-733	394	2	.	.	PUNCT
admet-733	395	1	280	280	NUM
admet-733	395	2	(	(	PUNCT
admet-733	395	3	2005	2005	NUM
admet-733	395	4	)	)	PUNCT
admet-733	395	5	11704	11704	NUM
admet-733	395	6	-	-	SYM
admet-733	395	7	11712	11712	NUM
admet-733	395	8	.	.	PUNCT
admet-733	396	1	[	[	X
admet-733	396	2	24	24	NUM
admet-733	396	3	]	]	PUNCT
admet-733	396	4	m.	m.	NOUN
admet-733	396	5	redhead	redhead	PROPN
admet-733	396	6	,	,	PUNCT
admet-733	396	7	r.	r.	PROPN
admet-733	396	8	satchell	satchell	PROPN
admet-733	396	9	,	,	PUNCT
admet-733	396	10	c.	c.	PROPN
admet-733	396	11	mccarthy	mccarthy	PROPN
admet-733	396	12	,	,	PUNCT
admet-733	396	13	s.	s.	PROPN
admet-733	396	14	pollack	pollack	PROPN
admet-733	396	15	,	,	PUNCT
admet-733	396	16	j.	j.	PROPN
admet-733	396	17	unitt	unitt	PROPN
admet-733	396	18	.	.	PUNCT
admet-733	397	1	thermal	thermal	ADJ
admet-733	397	2	shift	shift	NOUN
admet-733	397	3	as	as	ADP
admet-733	397	4	an	an	DET
admet-733	397	5	entropy	entropy	ADV
admet-733	397	6	-	-	PUNCT
admet-733	397	7	driven	drive	VERB
admet-733	397	8	effect	effect	NOUN
admet-733	397	9	.	.	PUNCT
admet-733	398	1	biochemistry	biochemistry	NOUN
admet-733	398	2	56	56	NUM
admet-733	398	3	(	(	PUNCT
admet-733	398	4	2017	2017	NUM
admet-733	398	5	)	)	PUNCT
admet-733	398	6	6187	6187	NUM
admet-733	398	7	-	-	SYM
admet-733	398	8	6199	6199	NUM
admet-733	398	9	.	.	PUNCT
admet-733	399	1	[	[	X
admet-733	399	2	25	25	NUM
admet-733	399	3	]	]	X
admet-733	399	4	d.a	d.a	PROPN
admet-733	399	5	.	.	PROPN
admet-733	399	6	erlanson	erlanson	PROPN
admet-733	399	7	,	,	PUNCT
admet-733	399	8	s.w	s.w	PROPN
admet-733	399	9	.	.	PROPN
admet-733	399	10	fesik	fesik	PROPN
admet-733	399	11	,	,	PUNCT
admet-733	399	12	r.e	r.e	PROPN
admet-733	399	13	.	.	PROPN
admet-733	399	14	hubbard	hubbard	PROPN
admet-733	399	15	,	,	PUNCT
admet-733	399	16	w.	w.	PROPN
admet-733	399	17	jahnke	jahnke	PROPN
admet-733	399	18	,	,	PUNCT
admet-733	399	19	h.	h.	PROPN
admet-733	399	20	jhoti	jhoti	PROPN
admet-733	399	21	.	.	PUNCT
admet-733	400	1	twenty	twenty	NUM
admet-733	400	2	years	year	NOUN
admet-733	400	3	on	on	ADP
admet-733	400	4	:	:	PUNCT
admet-733	400	5	the	the	DET
admet-733	400	6	impact	impact	NOUN
admet-733	400	7	of	of	ADP
admet-733	400	8	fragments	fragment	NOUN
admet-733	400	9	on	on	ADP
admet-733	400	10	drug	drug	NOUN
admet-733	400	11	discovery	discovery	NOUN
admet-733	400	12	.	.	PUNCT
admet-733	401	1	nat	nat	PROPN
admet-733	401	2	.	.	PUNCT
admet-733	402	1	rev	rev	PROPN
admet-733	402	2	.	.	PROPN
admet-733	402	3	drug	drug	NOUN
admet-733	402	4	discov	discov	NOUN
admet-733	402	5	.	.	PUNCT
admet-733	403	1	15	15	NUM
admet-733	403	2	(	(	PUNCT
admet-733	403	3	2016	2016	NUM
admet-733	403	4	)	)	PUNCT
admet-733	403	5	605	605	NUM
admet-733	403	6	-	-	SYM
admet-733	403	7	619	619	NUM
admet-733	403	8	.	.	PUNCT
admet-733	404	1	[	[	X
admet-733	404	2	26	26	NUM
admet-733	404	3	]	]	X
admet-733	404	4	p.	p.	PROPN
admet-733	404	5	linke	linke	PROPN
admet-733	404	6	,	,	PUNCT
admet-733	404	7	k.	k.	PROPN
admet-733	404	8	amaning	amaning	PROPN
admet-733	404	9	,	,	PUNCT
admet-733	404	10	m.	m.	NOUN
admet-733	404	11	maschberger	maschberger	PROPN
admet-733	404	12	,	,	PUNCT
admet-733	404	13	f.	f.	PROPN
admet-733	404	14	vallee	vallee	PROPN
admet-733	404	15	,	,	PUNCT
admet-733	404	16	v.	v.	ADP
admet-733	404	17	steier	steier	NOUN
admet-733	404	18	,	,	PUNCT
admet-733	404	19	p.	p.	PROPN
admet-733	404	20	baaske	baaske	PROPN
admet-733	404	21	,	,	PUNCT
admet-733	404	22	s.	s.	PROPN
admet-733	404	23	duhr	duhr	PROPN
admet-733	404	24	,	,	PUNCT
admet-733	404	25	d.	d.	PROPN
admet-733	404	26	breitsprecher	breitsprecher	PROPN
admet-733	404	27	,	,	PUNCT
admet-733	404	28	a.	a.	PROPN
admet-733	404	29	rak	rak	PROPN
admet-733	404	30	.	.	PUNCT
admet-733	405	1	an	an	DET
admet-733	405	2	automated	automate	VERB
admet-733	405	3	microscale	microscale	ADJ
admet-733	405	4	thermophoresis	thermophoresis	NOUN
admet-733	405	5	screening	screen	VERB
admet-733	405	6	approach	approach	NOUN
admet-733	405	7	for	for	ADP
admet-733	405	8	fragment	fragment	NOUN
admet-733	405	9	-	-	PUNCT
admet-733	405	10	based	base	VERB
admet-733	405	11	lead	lead	NOUN
admet-733	405	12	discovery	discovery	NOUN
admet-733	405	13	.	.	PUNCT
admet-733	406	1	j.	j.	PROPN
admet-733	406	2	biomol	biomol	PROPN
admet-733	406	3	.	.	PUNCT
admet-733	407	1	screen	screen	NOUN
admet-733	407	2	.	.	PUNCT
admet-733	408	1	21	21	NUM
admet-733	408	2	(	(	PUNCT
admet-733	408	3	2016	2016	NUM
admet-733	408	4	)	)	PUNCT
admet-733	408	5	414	414	NUM
admet-733	408	6	-	-	SYM
admet-733	408	7	421	421	NUM
admet-733	408	8	.	.	PUNCT
admet-733	409	1	[	[	X
admet-733	409	2	27	27	NUM
admet-733	409	3	]	]	SYM
admet-733	409	4	a.r	a.r	PROPN
admet-733	409	5	.	.	PROPN
admet-733	409	6	leach	leach	NOUN
admet-733	409	7	,	,	PUNCT
admet-733	409	8	m.m	m.m	PROPN
admet-733	409	9	.	.	PROPN
admet-733	409	10	hann	hann	PROPN
admet-733	409	11	.	.	PUNCT
admet-733	410	1	molecular	molecular	ADJ
admet-733	410	2	complexity	complexity	NOUN
admet-733	410	3	and	and	CCONJ
admet-733	410	4	fragment	fragment	NOUN
admet-733	410	5	-	-	PUNCT
admet-733	410	6	based	base	VERB
admet-733	410	7	drug	drug	NOUN
admet-733	410	8	discovery	discovery	NOUN
admet-733	410	9	:	:	PUNCT
admet-733	410	10	ten	ten	NUM
admet-733	410	11	years	year	NOUN
admet-733	410	12	on	on	ADP
admet-733	410	13	.	.	PUNCT
admet-733	411	1	curr	curr	PROPN
admet-733	411	2	.	.	PUNCT
admet-733	412	1	opin	opin	NOUN
admet-733	412	2	.	.	PUNCT
admet-733	413	1	chem	chem	NOUN
admet-733	413	2	.	.	PUNCT
admet-733	414	1	biol	biol	PROPN
admet-733	414	2	.	.	PUNCT
admet-733	415	1	15	15	NUM
admet-733	415	2	(	(	PUNCT
admet-733	415	3	2011	2011	NUM
admet-733	415	4	)	)	PUNCT
admet-733	415	5	489	489	NUM
admet-733	415	6	-	-	SYM
admet-733	415	7	496	496	NUM
admet-733	415	8	.	.	PUNCT
admet-733	416	1	[	[	X
admet-733	416	2	28	28	NUM
admet-733	416	3	]	]	X
admet-733	416	4	m.j	m.j	PROPN
admet-733	416	5	.	.	PROPN
admet-733	416	6	harner	harner	PROPN
admet-733	416	7	,	,	PUNCT
admet-733	416	8	a.o	a.o	PROPN
admet-733	416	9	.	.	PROPN
admet-733	416	10	frank	frank	PROPN
admet-733	416	11	,	,	PUNCT
admet-733	416	12	s.w	s.w	PROPN
admet-733	416	13	.	.	PROPN
admet-733	416	14	fesik	fesik	NOUN
admet-733	416	15	.	.	PUNCT
admet-733	417	1	fragment	fragment	NOUN
admet-733	417	2	-	-	PUNCT
admet-733	417	3	based	base	VERB
admet-733	417	4	drug	drug	NOUN
admet-733	417	5	discovery	discovery	NOUN
admet-733	417	6	using	use	VERB
admet-733	417	7	nmr	nmr	NOUN
admet-733	417	8	spectroscopy	spectroscopy	NOUN
admet-733	417	9	.	.	PUNCT
admet-733	418	1	j.	j.	PROPN
admet-733	418	2	biomol	biomol	PROPN
admet-733	418	3	.	.	PUNCT
admet-733	419	1	nmr	nmr	NOUN
admet-733	419	2	56	56	NUM
admet-733	419	3	(	(	PUNCT
admet-733	419	4	2013	2013	NUM
admet-733	419	5	)	)	PUNCT
admet-733	419	6	65	65	NUM
admet-733	419	7	-	-	SYM
admet-733	419	8	75	75	NUM
admet-733	419	9	.	.	PUNCT
admet-733	420	1	[	[	X
admet-733	420	2	29	29	NUM
admet-733	420	3	]	]	PUNCT
admet-733	420	4	a.m.	a.m.	NOUN
admet-733	421	1	giannetti	giannetti	PROPN
admet-733	421	2	.	.	PUNCT
admet-733	422	1	from	from	ADP
admet-733	422	2	experimental	experimental	ADJ
admet-733	422	3	design	design	NOUN
admet-733	422	4	to	to	ADP
admet-733	422	5	validated	validated	ADJ
admet-733	422	6	hits	hit	NOUN
admet-733	422	7	a	a	DET
admet-733	422	8	comprehensive	comprehensive	ADJ
admet-733	422	9	walk	walk	NOUN
admet-733	422	10	-	-	PUNCT
admet-733	422	11	through	through	NOUN
admet-733	422	12	of	of	ADP
admet-733	422	13	fragment	fragment	ADJ
admet-733	422	14	lead	lead	NOUN
admet-733	422	15	identification	identification	NOUN
admet-733	422	16	using	use	VERB
admet-733	422	17	surface	surface	NOUN
admet-733	422	18	plasmon	plasmon	ADJ
admet-733	422	19	resonance	resonance	NOUN
admet-733	422	20	.	.	PUNCT
admet-733	423	1	meth	meth	NOUN
admet-733	423	2	.	.	PUNCT
admet-733	424	1	enzymol	enzymol	PROPN
admet-733	424	2	.	.	PROPN
admet-733	425	1	493	493	NUM
admet-733	425	2	(	(	PUNCT
admet-733	425	3	2011	2011	NUM
admet-733	425	4	)	)	PUNCT
admet-733	425	5	169	169	NUM
admet-733	425	6	-	-	SYM
admet-733	425	7	218	218	NUM
admet-733	425	8	.	.	PUNCT
admet-733	426	1	[	[	X
admet-733	426	2	30	30	NUM
admet-733	426	3	]	]	X
admet-733	426	4	d.	d.	PROPN
admet-733	426	5	beckett	beckett	PROPN
admet-733	426	6	,	,	PUNCT
admet-733	426	7	e.	e.	PROPN
admet-733	426	8	kovaleva	kovaleva	PROPN
admet-733	426	9	,	,	PUNCT
admet-733	426	10	p.j	p.j	PROPN
admet-733	426	11	.	.	PROPN
admet-733	426	12	schatz	schatz	PROPN
admet-733	426	13	.	.	PUNCT
admet-733	427	1	a	a	DET
admet-733	427	2	minimal	minimal	ADJ
admet-733	427	3	peptide	peptide	NOUN
admet-733	427	4	substrate	substrate	NOUN
admet-733	427	5	in	in	ADP
admet-733	427	6	biotin	biotin	NOUN
admet-733	427	7	holoenzyme	holoenzyme	PROPN
admet-733	427	8	synthetasecatalyzed	synthetasecatalyze	VERB
admet-733	427	9	biotinylation	biotinylation	PROPN
admet-733	427	10	.	.	PUNCT
admet-733	428	1	protein	protein	NOUN
admet-733	428	2	sci	sci	PROPN
admet-733	428	3	.	.	PROPN
admet-733	428	4	8	8	NUM
admet-733	428	5	(	(	PUNCT
admet-733	428	6	1999	1999	NUM
admet-733	428	7	)	)	PUNCT
admet-733	428	8	921	921	NUM
admet-733	428	9	-	-	SYM
admet-733	428	10	929	929	NUM
admet-733	428	11	.	.	PUNCT
admet-733	429	1	[	[	X
admet-733	429	2	31	31	NUM
admet-733	429	3	]	]	X
admet-733	429	4	c.a	c.a	PROPN
admet-733	429	5	.	.	PROPN
admet-733	429	6	shepherd	shepherd	PROPN
admet-733	429	7	,	,	PUNCT
admet-733	429	8	a.l	a.l	PROPN
admet-733	429	9	.	.	PROPN
admet-733	429	10	hopkins	hopkins	PROPN
admet-733	429	11	,	,	PUNCT
admet-733	429	12	i.	i.	PROPN
admet-733	429	13	navratilova	navratilova	PROPN
admet-733	429	14	.	.	PUNCT
admet-733	430	1	fragment	fragment	NOUN
admet-733	430	2	screening	screening	NOUN
admet-733	430	3	by	by	ADP
admet-733	430	4	spr	spr	ADJ
admet-733	430	5	and	and	CCONJ
admet-733	430	6	advanced	advanced	ADJ
admet-733	430	7	application	application	NOUN
admet-733	430	8	to	to	ADP
admet-733	430	9	gpcrs	gpcrs	PROPN
admet-733	430	10	.	.	PUNCT
admet-733	431	1	prog	prog	PROPN
admet-733	431	2	.	.	PUNCT
admet-733	432	1	biophys	biophy	NOUN
admet-733	432	2	.	.	PUNCT
admet-733	433	1	mol	mol	X
admet-733	433	2	.	.	PUNCT
admet-733	434	1	biol	biol	PROPN
admet-733	434	2	.	.	PUNCT
admet-733	435	1	116	116	NUM
admet-733	435	2	(	(	PUNCT
admet-733	435	3	2014	2014	NUM
admet-733	435	4	)	)	PUNCT
admet-733	435	5	113	113	NUM
admet-733	435	6	-	-	SYM
admet-733	435	7	123	123	NUM
admet-733	435	8	.	.	PUNCT
admet-733	436	1	admet	admet	PROPN
admet-733	436	2	&	&	CCONJ
admet-733	436	3	dmpk	dmpk	PROPN
admet-733	436	4	7(4	7(4	NUM
admet-733	436	5	)	)	PUNCT
admet-733	436	6	(	(	PUNCT
admet-733	436	7	2019	2019	NUM
admet-733	436	8	)	)	PUNCT
admet-733	436	9	222	222	NUM
admet-733	436	10	-	-	PUNCT
admet-733	436	11	241	241	NUM
admet-733	436	12	biophysical	biophysical	ADJ
admet-733	436	13	methods	method	NOUN
admet-733	436	14	in	in	ADP
admet-733	436	15	early	early	ADJ
admet-733	436	16	drug	drug	NOUN
admet-733	436	17	discovery	discovery	NOUN
admet-733	436	18	doi	doi	PROPN
admet-733	436	19	:	:	PUNCT
admet-733	436	20	10.5599	10.5599	NUM
admet-733	436	21	/	/	SYM
admet-733	436	22	admet.733	admet.733	ADJ
admet-733	436	23	241	241	NUM
admet-733	436	24	[	[	X
admet-733	436	25	32	32	NUM
admet-733	436	26	]	]	X
admet-733	436	27	d.e	d.e	PROPN
admet-733	436	28	.	.	PROPN
admet-733	436	29	scott	scott	PROPN
admet-733	436	30	,	,	PUNCT
admet-733	436	31	m.t	m.t	PROPN
admet-733	436	32	.	.	PROPN
admet-733	436	33	ehebauer	ehebauer	PROPN
admet-733	436	34	,	,	PUNCT
admet-733	436	35	t.	t.	PROPN
admet-733	436	36	pukala	pukala	PROPN
admet-733	436	37	,	,	PUNCT
admet-733	436	38	m.	m.	NOUN
admet-733	436	39	marsh	marsh	PROPN
admet-733	436	40	,	,	PUNCT
admet-733	436	41	t.l	t.l	PROPN
admet-733	436	42	.	.	PROPN
admet-733	436	43	blundell	blundell	PROPN
admet-733	436	44	,	,	PUNCT
admet-733	436	45	a.r	a.r	PROPN
admet-733	436	46	.	.	PROPN
admet-733	436	47	venkitaraman	venkitaraman	NOUN
admet-733	436	48	,	,	PUNCT
admet-733	436	49	c.	c.	PROPN
admet-733	436	50	abell	abell	PROPN
admet-733	436	51	,	,	PUNCT
admet-733	436	52	m.	m.	NOUN
admet-733	436	53	hyvönen	hyvönen	PROPN
admet-733	436	54	.	.	PUNCT
admet-733	437	1	using	use	VERB
admet-733	437	2	a	a	DET
admet-733	437	3	fragment	fragment	NOUN
admet-733	437	4	-	-	PUNCT
admet-733	437	5	based	base	VERB
admet-733	437	6	approach	approach	NOUN
admet-733	437	7	to	to	PART
admet-733	437	8	target	target	VERB
admet-733	437	9	protein	protein	NOUN
admet-733	437	10	-	-	PUNCT
admet-733	437	11	protein	protein	NOUN
admet-733	437	12	interactions	interaction	NOUN
admet-733	437	13	.	.	PUNCT
admet-733	438	1	chembiochem	chembiochem	PROPN
admet-733	438	2	14	14	NUM
admet-733	438	3	(	(	PUNCT
admet-733	438	4	2013	2013	NUM
admet-733	438	5	)	)	PUNCT
admet-733	438	6	332	332	NUM
admet-733	438	7	-	-	SYM
admet-733	438	8	342	342	NUM
admet-733	438	9	.	.	PUNCT
admet-733	439	1	[	[	X
admet-733	439	2	33	33	NUM
admet-733	439	3	]	]	PUNCT
admet-733	439	4	m.	m.	NOUN
admet-733	439	5	jerabek	jerabek	NOUN
admet-733	439	6	-	-	PUNCT
admet-733	439	7	willemsen	willemsen	NOUN
admet-733	439	8	,	,	PUNCT
admet-733	439	9	c.j	c.j	PROPN
admet-733	439	10	.	.	PROPN
admet-733	439	11	wienken	wienken	PROPN
admet-733	439	12	,	,	PUNCT
admet-733	439	13	d.	d.	PROPN
admet-733	439	14	braun	braun	PROPN
admet-733	439	15	,	,	PUNCT
admet-733	439	16	p.	p.	PROPN
admet-733	439	17	baaske	baaske	PROPN
admet-733	439	18	,	,	PUNCT
admet-733	439	19	s.	s.	PROPN
admet-733	439	20	duhr	duhr	PROPN
admet-733	439	21	.	.	PUNCT
admet-733	440	1	molecular	molecular	ADJ
admet-733	440	2	interaction	interaction	NOUN
admet-733	440	3	studies	study	NOUN
admet-733	440	4	using	use	VERB
admet-733	440	5	microscale	microscale	ADJ
admet-733	440	6	thermophoresis	thermophoresis	NOUN
admet-733	440	7	.	.	PUNCT
admet-733	441	1	assay	assay	PROPN
admet-733	441	2	drug	drug	PROPN
admet-733	441	3	dev	dev	PROPN
admet-733	441	4	.	.	PUNCT
admet-733	442	1	technol	technol	PROPN
admet-733	442	2	.	.	PROPN
admet-733	442	3	9	9	NUM
admet-733	442	4	(	(	PUNCT
admet-733	442	5	2011	2011	NUM
admet-733	442	6	)	)	PUNCT
admet-733	442	7	342	342	NUM
admet-733	442	8	-	-	SYM
admet-733	442	9	353	353	NUM
admet-733	442	10	.	.	PUNCT
admet-733	443	1	[	[	X
admet-733	443	2	34	34	NUM
admet-733	443	3	]	]	X
admet-733	443	4	p.	p.	PROPN
admet-733	443	5	linke	linke	PROPN
admet-733	443	6	,	,	PUNCT
admet-733	443	7	k.	k.	PROPN
admet-733	443	8	amaning	amaning	PROPN
admet-733	443	9	,	,	PUNCT
admet-733	443	10	m.	m.	NOUN
admet-733	443	11	maschberger	maschberger	PROPN
admet-733	443	12	,	,	PUNCT
admet-733	443	13	f.	f.	PROPN
admet-733	443	14	vallee	vallee	PROPN
admet-733	443	15	,	,	PUNCT
admet-733	443	16	v.	v.	ADP
admet-733	443	17	steier	steier	NOUN
admet-733	443	18	,	,	PUNCT
admet-733	443	19	p.	p.	PROPN
admet-733	443	20	baaske	baaske	PROPN
admet-733	443	21	,	,	PUNCT
admet-733	443	22	s.	s.	PROPN
admet-733	443	23	duhr	duhr	PROPN
admet-733	443	24	,	,	PUNCT
admet-733	443	25	d.	d.	PROPN
admet-733	443	26	breitsprecher	breitsprecher	PROPN
admet-733	443	27	,	,	PUNCT
admet-733	443	28	a.	a.	PROPN
admet-733	443	29	rak	rak	PROPN
admet-733	443	30	.	.	PUNCT
admet-733	444	1	an	an	DET
admet-733	444	2	automated	automate	VERB
admet-733	444	3	microscale	microscale	ADJ
admet-733	444	4	thermophoresis	thermophoresis	NOUN
admet-733	444	5	screening	screen	VERB
admet-733	444	6	approach	approach	NOUN
admet-733	444	7	for	for	ADP
admet-733	444	8	fragment	fragment	NOUN
admet-733	444	9	-	-	PUNCT
admet-733	444	10	based	base	VERB
admet-733	444	11	lead	lead	NOUN
admet-733	444	12	discovery	discovery	NOUN
admet-733	444	13	.	.	PUNCT
admet-733	445	1	j	j	PROPN
admet-733	445	2	biomol	biomol	PROPN
admet-733	445	3	.	.	PUNCT
admet-733	446	1	screen	screen	NOUN
admet-733	446	2	.	.	PUNCT
admet-733	447	1	21	21	NUM
admet-733	447	2	(	(	PUNCT
admet-733	447	3	2016	2016	NUM
admet-733	447	4	)	)	PUNCT
admet-733	447	5	414	414	NUM
admet-733	447	6	-	-	SYM
admet-733	447	7	421	421	NUM
admet-733	447	8	.	.	PUNCT
admet-733	448	1	[	[	X
admet-733	448	2	35	35	NUM
admet-733	448	3	]	]	X
admet-733	448	4	c.c	c.c	PROPN
admet-733	448	5	.	.	PROPN
admet-733	448	6	genick	genick	PROPN
admet-733	448	7	,	,	PUNCT
admet-733	448	8	d.	d.	PROPN
admet-733	448	9	barlier	barlier	NOUN
admet-733	448	10	,	,	PUNCT
admet-733	448	11	d.	d.	PROPN
admet-733	448	12	monna	monna	PROPN
admet-733	448	13	,	,	PUNCT
admet-733	448	14	r.	r.	PROPN
admet-733	448	15	brunner	brunner	PROPN
admet-733	448	16	,	,	PUNCT
admet-733	448	17	c.	c.	PROPN
admet-733	448	18	bé	bé	PROPN
admet-733	448	19	,	,	PUNCT
admet-733	448	20	c.	c.	NOUN
admet-733	448	21	scheufler	scheufler	NOUN
admet-733	448	22	,	,	PUNCT
admet-733	448	23	j.	j.	PROPN
admet-733	448	24	ottl	ottl	PROPN
admet-733	448	25	.	.	PUNCT
admet-733	449	1	applications	application	NOUN
admet-733	449	2	of	of	ADP
admet-733	449	3	biophysics	biophysic	NOUN
admet-733	449	4	in	in	ADP
admet-733	449	5	high	high	ADJ
admet-733	449	6	-	-	PUNCT
admet-733	449	7	throughput	throughput	NOUN
admet-733	449	8	screening	screening	NOUN
admet-733	449	9	hit	hit	VERB
admet-733	449	10	validation	validation	NOUN
admet-733	449	11	.	.	PUNCT
admet-733	450	1	j.	j.	PROPN
admet-733	450	2	biomol	biomol	PROPN
admet-733	450	3	.	.	PUNCT
admet-733	451	1	screen	screen	NOUN
admet-733	451	2	.	.	PUNCT
admet-733	452	1	19	19	NUM
admet-733	452	2	(	(	PUNCT
admet-733	452	3	2014	2014	NUM
admet-733	452	4	)	)	PUNCT
admet-733	452	5	707	707	NUM
admet-733	452	6	-	-	SYM
admet-733	452	7	714	714	NUM
admet-733	452	8	.	.	PUNCT
admet-733	453	1	[	[	X
admet-733	453	2	36	36	NUM
admet-733	453	3	]	]	X
admet-733	453	4	d.	d.	PROPN
admet-733	453	5	martinez	martinez	PROPN
admet-733	453	6	molina	molina	PROPN
admet-733	453	7	,	,	PUNCT
admet-733	453	8	p.	p.	PROPN
admet-733	453	9	nordlund	nordlund	PROPN
admet-733	453	10	.	.	PUNCT
admet-733	454	1	the	the	DET
admet-733	454	2	cellular	cellular	ADJ
admet-733	454	3	thermal	thermal	ADJ
admet-733	454	4	shift	shift	NOUN
admet-733	454	5	assay	assay	VERB
admet-733	454	6	:	:	PUNCT
admet-733	454	7	a	a	DET
admet-733	454	8	novel	novel	ADJ
admet-733	454	9	biophysical	biophysical	ADJ
admet-733	454	10	assay	assay	NOUN
admet-733	454	11	for	for	ADP
admet-733	454	12	in	in	ADP
admet-733	454	13	situ	situ	ADJ
admet-733	454	14	drug	drug	NOUN
admet-733	454	15	target	target	NOUN
admet-733	454	16	engagement	engagement	NOUN
admet-733	454	17	and	and	CCONJ
admet-733	454	18	mechanistic	mechanistic	ADJ
admet-733	454	19	biomarker	biomarker	NOUN
admet-733	454	20	studies	study	NOUN
admet-733	454	21	.	.	PUNCT
admet-733	455	1	annu	annu	NOUN
admet-733	455	2	.	.	PUNCT
admet-733	456	1	rev	rev	PROPN
admet-733	456	2	.	.	PROPN
admet-733	456	3	pharmacol	pharmacol	PROPN
admet-733	456	4	.	.	PUNCT
admet-733	457	1	toxicol	toxicol	PROPN
admet-733	457	2	.	.	PUNCT
admet-733	458	1	56	56	NUM
admet-733	458	2	(	(	PUNCT
admet-733	458	3	2016	2016	NUM
admet-733	458	4	)	)	PUNCT
admet-733	458	5	141	141	NUM
admet-733	458	6	-	-	SYM
admet-733	458	7	161	161	NUM
admet-733	458	8	.	.	PUNCT
admet-733	459	1	[	[	X
admet-733	459	2	37	37	NUM
admet-733	459	3	]	]	PUNCT
admet-733	459	4	t.	t.	PROPN
admet-733	459	5	klein	klein	PROPN
admet-733	459	6	,	,	PUNCT
admet-733	459	7	n.	n.	PROPN
admet-733	459	8	vajpai	vajpai	NOUN
admet-733	459	9	,	,	PUNCT
admet-733	459	10	j.j	j.j	PROPN
admet-733	459	11	.	.	PROPN
admet-733	459	12	phillips	phillips	PROPN
admet-733	459	13	,	,	PUNCT
admet-733	459	14	g.	g.	PROPN
admet-733	459	15	davies	davies	PROPN
admet-733	459	16	,	,	PUNCT
admet-733	459	17	g.a	g.a	PROPN
admet-733	459	18	.	.	PROPN
admet-733	459	19	holdgate	holdgate	PROPN
admet-733	459	20	,	,	PUNCT
admet-733	459	21	c.	c.	PROPN
admet-733	459	22	phillips	phillips	PROPN
admet-733	459	23	,	,	PUNCT
admet-733	459	24	j.a	j.a	PROPN
admet-733	459	25	.	.	PROPN
admet-733	459	26	tucker	tucker	PROPN
admet-733	459	27	,	,	PUNCT
admet-733	459	28	r.a	r.a	PROPN
admet-733	459	29	.	.	PROPN
admet-733	459	30	norman	norman	PROPN
admet-733	459	31	,	,	PUNCT
admet-733	459	32	a.d	a.d	PROPN
admet-733	459	33	.	.	PROPN
admet-733	459	34	scott	scott	PROPN
admet-733	459	35	,	,	PUNCT
admet-733	459	36	d.r	d.r	PROPN
admet-733	459	37	.	.	PROPN
admet-733	459	38	higazi	higazi	PROPN
admet-733	459	39	,	,	PUNCT
admet-733	459	40	d.	d.	PROPN
admet-733	459	41	lowe	lowe	PROPN
admet-733	459	42	,	,	PUNCT
admet-733	459	43	g.s	g.s	PROPN
admet-733	459	44	.	.	PROPN
admet-733	459	45	thompson	thompson	PROPN
admet-733	459	46	,	,	PUNCT
admet-733	459	47	a.l	a.l	PROPN
admet-733	459	48	.	.	PROPN
admet-733	459	49	breeze	breeze	PROPN
admet-733	459	50	.	.	PUNCT
admet-733	460	1	structural	structural	ADJ
admet-733	460	2	and	and	CCONJ
admet-733	460	3	dynamic	dynamic	ADJ
admet-733	460	4	insights	insight	NOUN
admet-733	460	5	into	into	ADP
admet-733	460	6	the	the	DET
admet-733	460	7	energetics	energetic	NOUN
admet-733	460	8	of	of	ADP
admet-733	460	9	activation	activation	NOUN
admet-733	460	10	loop	loop	NOUN
admet-733	460	11	rearrangement	rearrangement	NOUN
admet-733	460	12	in	in	ADP
admet-733	460	13	fgfr1	fgfr1	PROPN
admet-733	460	14	kinase	kinase	PROPN
admet-733	460	15	.	.	PUNCT
admet-733	461	1	nat	nat	PROPN
admet-733	461	2	.	.	PUNCT
admet-733	462	1	commun	commun	PROPN
admet-733	462	2	.	.	PROPN
admet-733	463	1	6	6	NUM
admet-733	463	2	(	(	PUNCT
admet-733	463	3	2015	2015	NUM
admet-733	463	4	)	)	PUNCT
admet-733	463	5	7877	7877	NUM
admet-733	463	6	.	.	PUNCT
admet-733	464	1	[	[	X
admet-733	464	2	38	38	NUM
admet-733	464	3	]	]	X
admet-733	464	4	p.j	p.j	PROPN
admet-733	464	5	.	.	PROPN
admet-733	464	6	tonge	tonge	PROPN
admet-733	464	7	.	.	PUNCT
admet-733	464	8	drug	drug	NOUN
admet-733	464	9	-	-	PUNCT
admet-733	464	10	target	target	NOUN
admet-733	464	11	kinetics	kinetic	NOUN
admet-733	464	12	in	in	ADP
admet-733	464	13	drug	drug	NOUN
admet-733	464	14	discovery	discovery	NOUN
admet-733	464	15	.	.	PUNCT
admet-733	465	1	acs	acs	PROPN
admet-733	465	2	chem	chem	PROPN
admet-733	465	3	.	.	PUNCT
admet-733	466	1	neurosci	neurosci	PROPN
admet-733	466	2	.	.	PUNCT
admet-733	467	1	9	9	NUM
admet-733	467	2	(	(	PUNCT
admet-733	467	3	2018	2018	NUM
admet-733	467	4	)	)	PUNCT
admet-733	467	5	29	29	NUM
admet-733	467	6	-	-	SYM
admet-733	467	7	39	39	NUM
admet-733	467	8	.	.	PUNCT
admet-733	468	1	[	[	X
admet-733	468	2	39	39	NUM
admet-733	468	3	]	]	PUNCT
admet-733	468	4	r.	r.	PROPN
admet-733	468	5	possemato	possemato	PROPN
admet-733	468	6	,	,	PUNCT
admet-733	468	7	k.m	k.m	PROPN
admet-733	468	8	.	.	PROPN
admet-733	468	9	marks	marks	PROPN
admet-733	468	10	,	,	PUNCT
admet-733	468	11	y.d	y.d	PROPN
admet-733	468	12	.	.	PROPN
admet-733	468	13	shaul	shaul	PROPN
admet-733	468	14	,	,	PUNCT
admet-733	468	15	m.e	m.e	PROPN
admet-733	468	16	.	.	PROPN
admet-733	468	17	pacold	pacold	PROPN
admet-733	468	18	,	,	PUNCT
admet-733	468	19	d.	d.	PROPN
admet-733	468	20	kim	kim	PROPN
admet-733	468	21	,	,	PUNCT
admet-733	468	22	k.	k.	PROPN
admet-733	468	23	birsoy	birsoy	PROPN
admet-733	468	24	,	,	PUNCT
admet-733	468	25	s.	s.	PROPN
admet-733	468	26	sethumadhavan	sethumadhavan	PROPN
admet-733	468	27	,	,	PUNCT
admet-733	468	28	h.k	h.k	PROPN
admet-733	468	29	.	.	PROPN
admet-733	468	30	woo	woo	PROPN
admet-733	468	31	,	,	PUNCT
admet-733	468	32	h.g	h.g	PROPN
admet-733	468	33	.	.	PROPN
admet-733	468	34	jang	jang	PROPN
admet-733	468	35	,	,	PUNCT
admet-733	468	36	a.k	a.k	PROPN
admet-733	468	37	.	.	PROPN
admet-733	468	38	jha	jha	PROPN
admet-733	468	39	,	,	PUNCT
admet-733	468	40	w.w	w.w	PROPN
admet-733	468	41	.	.	PROPN
admet-733	468	42	chen	chen	PROPN
admet-733	468	43	,	,	PUNCT
admet-733	468	44	f.g	f.g	PROPN
admet-733	468	45	.	.	PROPN
admet-733	468	46	barrett	barrett	PROPN
admet-733	468	47	,	,	PUNCT
admet-733	468	48	n.	n.	PROPN
admet-733	468	49	stransky	stransky	PROPN
admet-733	468	50	,	,	PUNCT
admet-733	468	51	z.y	z.y	PROPN
admet-733	468	52	.	.	PROPN
admet-733	468	53	tsun	tsun	PROPN
admet-733	468	54	,	,	PUNCT
admet-733	468	55	g.s	g.s	PROPN
admet-733	468	56	.	.	PROPN
admet-733	468	57	cowley	cowley	PROPN
admet-733	468	58	,	,	PUNCT
admet-733	468	59	j.	j.	PROPN
admet-733	468	60	barretina	barretina	PROPN
admet-733	468	61	,	,	PUNCT
admet-733	468	62	n.y	n.y	PROPN
admet-733	468	63	.	.	PROPN
admet-733	468	64	kalaany	kalaany	PROPN
admet-733	468	65	,	,	PUNCT
admet-733	468	66	p.p	p.p	PROPN
admet-733	468	67	.	.	PROPN
admet-733	468	68	hsu	hsu	PROPN
admet-733	468	69	,	,	PUNCT
admet-733	468	70	k.	k.	PROPN
admet-733	468	71	ottina	ottina	PROPN
admet-733	468	72	,	,	PUNCT
admet-733	468	73	a.m.	a.m.	PROPN
admet-733	468	74	chan	chan	PROPN
admet-733	468	75	,	,	PUNCT
admet-733	468	76	b.	b.	PROPN
admet-733	468	77	yuan	yuan	PROPN
admet-733	468	78	,	,	PUNCT
admet-733	468	79	l.a	l.a	PROPN
admet-733	468	80	.	.	PROPN
admet-733	468	81	garraway	garraway	PROPN
admet-733	468	82	,	,	PUNCT
admet-733	468	83	d.e	d.e	PROPN
admet-733	468	84	.	.	PROPN
admet-733	468	85	root	root	PROPN
admet-733	468	86	,	,	PUNCT
admet-733	468	87	m.	m.	NOUN
admet-733	468	88	mino	mino	PROPN
admet-733	468	89	-	-	PUNCT
admet-733	468	90	kenudson	kenudson	NOUN
admet-733	468	91	,	,	PUNCT
admet-733	468	92	e.f	e.f	PROPN
admet-733	468	93	.	.	PROPN
admet-733	468	94	brachtel	brachtel	PROPN
admet-733	468	95	,	,	PUNCT
admet-733	468	96	e.m	e.m	PROPN
admet-733	468	97	.	.	PROPN
admet-733	468	98	driggers	drigger	NOUN
admet-733	468	99	,	,	PUNCT
admet-733	468	100	d.m	d.m	PROPN
admet-733	468	101	.	.	PUNCT
admet-733	468	102	sabatini	sabatini	PROPN
admet-733	468	103	.	.	PROPN
admet-733	468	104	functional	functional	ADJ
admet-733	468	105	genomics	genomic	NOUN
admet-733	468	106	reveal	reveal	VERB
admet-733	468	107	that	that	SCONJ
admet-733	468	108	the	the	DET
admet-733	468	109	serine	serine	ADJ
admet-733	468	110	synthesis	synthesis	NOUN
admet-733	468	111	pathway	pathway	NOUN
admet-733	468	112	is	be	AUX
admet-733	468	113	essential	essential	ADJ
admet-733	468	114	in	in	ADP
admet-733	468	115	breast	breast	NOUN
admet-733	468	116	cancer	cancer	NOUN
admet-733	468	117	.	.	PUNCT
admet-733	469	1	nature	nature	NOUN
admet-733	469	2	476	476	NUM
admet-733	469	3	(	(	PUNCT
admet-733	469	4	2011	2011	NUM
admet-733	469	5	)	)	PUNCT
admet-733	469	6	346	346	NUM
admet-733	469	7	-	-	SYM
admet-733	469	8	350	350	NUM
admet-733	469	9	.	.	PUNCT
admet-733	470	1	[	[	X
admet-733	470	2	40	40	NUM
admet-733	470	3	]	]	PUNCT
admet-733	470	4	d.	d.	PROPN
admet-733	470	5	neri	neri	PROPN
admet-733	470	6	,	,	PUNCT
admet-733	470	7	r.a	r.a	PROPN
admet-733	470	8	.	.	PROPN
admet-733	470	9	lerner	lerner	PROPN
admet-733	470	10	.	.	PUNCT
admet-733	471	1	dna	dna	PROPN
admet-733	471	2	-	-	PUNCT
admet-733	471	3	encoded	encode	VERB
admet-733	471	4	chemical	chemical	NOUN
admet-733	471	5	libraries	library	NOUN
admet-733	471	6	:	:	PUNCT
admet-733	471	7	a	a	DET
admet-733	471	8	selection	selection	NOUN
admet-733	471	9	system	system	NOUN
admet-733	471	10	based	base	VERB
admet-733	471	11	on	on	ADP
admet-733	471	12	endowing	endow	VERB
admet-733	471	13	organic	organic	ADJ
admet-733	471	14	compounds	compound	NOUN
admet-733	471	15	with	with	ADP
admet-733	471	16	amplifiable	amplifiable	ADJ
admet-733	471	17	information	information	NOUN
admet-733	471	18	.	.	PUNCT
admet-733	472	1	annu	annu	NOUN
admet-733	472	2	.	.	PUNCT
admet-733	473	1	rev	rev	PROPN
admet-733	473	2	.	.	PROPN
admet-733	473	3	biochem	biochem	PROPN
admet-733	473	4	.	.	PUNCT
admet-733	474	1	87	87	NUM
admet-733	474	2	(	(	PUNCT
admet-733	474	3	2018	2018	NUM
admet-733	474	4	)	)	PUNCT
admet-733	474	5	479	479	NUM
admet-733	474	6	-	-	SYM
admet-733	474	7	502	502	NUM
admet-733	474	8	.	.	PUNCT
admet-733	475	1	[	[	X
admet-733	475	2	41	41	NUM
admet-733	475	3	]	]	X
admet-733	475	4	g.	g.	PROPN
admet-733	475	5	holdgate	holdgate	PROPN
admet-733	475	6	,	,	PUNCT
admet-733	475	7	s.	s.	PROPN
admet-733	475	8	geschwindner	geschwindner	PROPN
admet-733	475	9	,	,	PUNCT
admet-733	475	10	a.	a.	NOUN
admet-733	475	11	breeze	breeze	PROPN
admet-733	475	12	,	,	PUNCT
admet-733	475	13	g.	g.	PROPN
admet-733	475	14	davies	davy	NOUN
admet-733	475	15	,	,	PUNCT
admet-733	475	16	n.	n.	PROPN
admet-733	475	17	colclough	colclough	PROPN
admet-733	475	18	,	,	PUNCT
admet-733	475	19	d.	d.	PROPN
admet-733	475	20	temesi	temesi	PROPN
admet-733	475	21	,	,	PUNCT
admet-733	475	22	l.	l.	PROPN
admet-733	475	23	ward	ward	PROPN
admet-733	475	24	.	.	PUNCT
admet-733	476	1	biophysical	biophysical	ADJ
admet-733	476	2	methods	method	NOUN
admet-733	476	3	in	in	ADP
admet-733	476	4	drug	drug	NOUN
admet-733	476	5	discovery	discovery	NOUN
admet-733	476	6	from	from	ADP
admet-733	476	7	small	small	ADJ
admet-733	476	8	molecule	molecule	NOUN
admet-733	476	9	to	to	ADP
admet-733	476	10	pharmaceutical	pharmaceutical	NOUN
admet-733	476	11	.	.	PUNCT
admet-733	477	1	methods	method	NOUN
admet-733	477	2	mol	mol	PROPN
admet-733	477	3	.	.	PUNCT
admet-733	478	1	biol	biol	PROPN
admet-733	478	2	.	.	PUNCT
admet-733	479	1	1008	1008	NUM
admet-733	479	2	(	(	PUNCT
admet-733	479	3	2013	2013	NUM
admet-733	479	4	)	)	PUNCT
admet-733	479	5	327	327	NUM
admet-733	479	6	-	-	SYM
admet-733	479	7	355	355	NUM
admet-733	479	8	.	.	PUNCT
admet-733	480	1	©	©	SYM
admet-733	480	2	2019	2019	NUM
admet-733	480	3	by	by	ADP
admet-733	480	4	the	the	DET
admet-733	480	5	authors	author	NOUN
admet-733	480	6	;	;	PUNCT
admet-733	480	7	licensee	licensee	PROPN
admet-733	480	8	iapc	iapc	PROPN
admet-733	480	9	,	,	PUNCT
admet-733	480	10	zagreb	zagreb	PROPN
admet-733	480	11	,	,	PUNCT
admet-733	480	12	croatia	croatia	PROPN
admet-733	480	13	.	.	PUNCT
admet-733	481	1	this	this	DET
admet-733	481	2	article	article	NOUN
admet-733	481	3	is	be	AUX
admet-733	481	4	an	an	DET
admet-733	481	5	open	open	ADJ
admet-733	481	6	-	-	PUNCT
admet-733	481	7	access	access	NOUN
admet-733	481	8	article	article	NOUN
admet-733	481	9	distributed	distribute	VERB
admet-733	481	10	under	under	ADP
admet-733	481	11	the	the	DET
admet-733	481	12	terms	term	NOUN
admet-733	481	13	and	and	CCONJ
admet-733	481	14	conditions	condition	NOUN
admet-733	481	15	of	of	ADP
admet-733	481	16	the	the	DET
admet-733	481	17	creative	creative	ADJ
admet-733	481	18	commons	common	NOUN
admet-733	481	19	attribution	attribution	NOUN
admet-733	481	20	license	license	NOUN
admet-733	481	21	(	(	PUNCT
admet-733	481	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-733	481	23	)	)	PUNCT
admet-733	481	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN