id	sid	tid	token	lemma	pos
admet-737	1	1	nmr	nmr	NOUN
admet-737	1	2	spectroscopy	spectroscopy	VERB
admet-737	1	3	in	in	ADP
admet-737	1	4	drug	drug	NOUN
admet-737	1	5	discovery	discovery	NOUN
admet-737	1	6	and	and	CCONJ
admet-737	1	7	development	development	NOUN
admet-737	1	8	:	:	PUNCT
admet-737	1	9	evaluation	evaluation	NOUN
admet-737	1	10	of	of	ADP
admet-737	1	11	physico	physico	NOUN
admet-737	1	12	-	-	PUNCT
admet-737	1	13	chemical	chemical	NOUN
admet-737	1	14	properties	property	NOUN
admet-737	1	15	doi	doi	NOUN
admet-737	1	16	:	:	PUNCT
admet-737	1	17	10.5599	10.5599	NUM
admet-737	1	18	/	/	SYM
admet-737	1	19	admet.737	admet.737	PROPN
admet-737	1	20	242	242	NUM
admet-737	1	21	admet	admet	X
admet-737	1	22	&	&	CCONJ
admet-737	1	23	dmpk	dmpk	PROPN
admet-737	1	24	7(4	7(4	NUM
admet-737	1	25	)	)	PUNCT
admet-737	1	26	(	(	PUNCT
admet-737	1	27	2019	2019	NUM
admet-737	1	28	)	)	PUNCT
admet-737	1	29	242	242	NUM
admet-737	1	30	-	-	SYM
admet-737	1	31	251	251	NUM
admet-737	1	32	;	;	PUNCT
admet-737	1	33	doi	doi	NOUN
admet-737	1	34	:	:	PUNCT
admet-737	1	35	http://dx.doi.org/10.5599/admet.737	http://dx.doi.org/10.5599/admet.737	VERB
admet-737	1	36	open	open	ADJ
admet-737	1	37	access	access	NOUN
admet-737	1	38	:	:	PUNCT
admet-737	1	39	issn	issn	PROPN
admet-737	1	40	:	:	PUNCT
admet-737	1	41	1848	1848	NUM
admet-737	1	42	-	-	SYM
admet-737	1	43	7718	7718	NUM
admet-737	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-737	1	45	review	review	NOUN
admet-737	1	46	nmr	nmr	NOUN
admet-737	1	47	spectroscopy	spectroscopy	VERB
admet-737	1	48	in	in	ADP
admet-737	1	49	drug	drug	NOUN
admet-737	1	50	discovery	discovery	NOUN
admet-737	1	51	and	and	CCONJ
admet-737	1	52	development	development	NOUN
admet-737	1	53	:	:	PUNCT
admet-737	1	54	evaluation	evaluation	NOUN
admet-737	1	55	of	of	ADP
admet-737	1	56	physico	physico	NOUN
admet-737	1	57	-	-	PUNCT
admet-737	1	58	chemical	chemical	NOUN
admet-737	1	59	properties	property	NOUN
admet-737	1	60	mire	mire	VERB
admet-737	1	61	zloh	zloh	PROPN
admet-737	1	62	ucl	ucl	PROPN
admet-737	1	63	school	school	NOUN
admet-737	1	64	of	of	ADP
admet-737	1	65	pharmacy	pharmacy	NOUN
admet-737	1	66	,	,	PUNCT
admet-737	1	67	university	university	NOUN
admet-737	1	68	college	college	PROPN
admet-737	1	69	london	london	PROPN
admet-737	1	70	,	,	PUNCT
admet-737	1	71	29/39	29/39	NUM
admet-737	1	72	brunswick	brunswick	PROPN
admet-737	1	73	square	square	PROPN
admet-737	1	74	,	,	PUNCT
admet-737	1	75	london	london	PROPN
admet-737	1	76	,	,	PUNCT
admet-737	1	77	wc1n	wc1n	PROPN
admet-737	1	78	1ax	1ax	NOUN
admet-737	1	79	,	,	PUNCT
admet-737	1	80	uk	uk	PROPN
admet-737	1	81	faculty	faculty	NOUN
admet-737	1	82	of	of	ADP
admet-737	1	83	pharmacy	pharmacy	NOUN
admet-737	1	84	,	,	PUNCT
admet-737	1	85	university	university	NOUN
admet-737	1	86	business	business	NOUN
admet-737	1	87	academy	academy	PROPN
admet-737	1	88	,	,	PUNCT
admet-737	1	89	trg	trg	PROPN
admet-737	1	90	mladenaca	mladenaca	NOUN
admet-737	1	91	5	5	NUM
admet-737	1	92	,	,	PUNCT
admet-737	1	93	21000	21000	NUM
admet-737	1	94	,	,	PUNCT
admet-737	1	95	novi	novi	PROPN
admet-737	1	96	sad	sad	PROPN
admet-737	1	97	,	,	PUNCT
admet-737	1	98	serbia	serbia	PROPN
admet-737	1	99	*	*	PUNCT
admet-737	1	100	corresponding	correspond	VERB
admet-737	1	101	author	author	NOUN
admet-737	1	102	:	:	PUNCT
admet-737	1	103	e	e	NOUN
admet-737	1	104	-	-	NOUN
admet-737	1	105	mail	mail	NOUN
admet-737	1	106	:	:	PUNCT
admet-737	1	107	zloh@live.co.uk	zloh@live.co.uk	NOUN
admet-737	1	108	;	;	PUNCT
admet-737	1	109	tel	tel	PROPN
admet-737	1	110	.	.	PUNCT
admet-737	1	111	:	:	PUNCT
admet-737	2	1	+44	+44	PROPN
admet-737	2	2	-	-	PUNCT
admet-737	2	3	777	777	NUM
admet-737	2	4	-	-	PUNCT
admet-737	2	5	00	00	NUM
admet-737	2	6	-	-	PUNCT
admet-737	2	7	23411	23411	NUM
admet-737	2	8	received	receive	VERB
admet-737	2	9	:	:	PUNCT
admet-737	2	10	october	october	PROPN
admet-737	2	11	18	18	NUM
admet-737	2	12	,	,	PUNCT
admet-737	2	13	2019	2019	NUM
admet-737	2	14	;	;	PUNCT
admet-737	2	15	revised	revise	VERB
admet-737	2	16	:	:	PUNCT
admet-737	2	17	november	november	PROPN
admet-737	2	18	19	19	NUM
admet-737	2	19	,	,	PUNCT
admet-737	2	20	2019	2019	NUM
admet-737	2	21	;	;	PUNCT
admet-737	2	22	published	publish	VERB
admet-737	2	23	:	:	PUNCT
admet-737	2	24	december	december	PROPN
admet-737	2	25	11	11	NUM
admet-737	2	26	,	,	PUNCT
admet-737	2	27	2019	2019	NUM
admet-737	2	28	abstract	abstract	ADJ
admet-737	2	29	determination	determination	NOUN
admet-737	2	30	of	of	ADP
admet-737	2	31	physico	physico	NOUN
admet-737	2	32	-	-	PUNCT
admet-737	2	33	chemical	chemical	NOUN
admet-737	2	34	properties	property	NOUN
admet-737	2	35	of	of	ADP
admet-737	2	36	compounds	compound	NOUN
admet-737	2	37	is	be	AUX
admet-737	2	38	one	one	NUM
admet-737	2	39	of	of	ADP
admet-737	2	40	the	the	DET
admet-737	2	41	corner	corner	NOUN
admet-737	2	42	-	-	PUNCT
admet-737	2	43	stones	stone	NOUN
admet-737	2	44	in	in	ADP
admet-737	2	45	selection	selection	NOUN
admet-737	2	46	of	of	ADP
admet-737	2	47	hit	hit	VERB
admet-737	2	48	molecules	molecule	NOUN
admet-737	2	49	for	for	ADP
admet-737	2	50	further	further	ADJ
admet-737	2	51	progression	progression	NOUN
admet-737	2	52	into	into	ADP
admet-737	2	53	lead	lead	ADJ
admet-737	2	54	development	development	NOUN
admet-737	2	55	in	in	ADP
admet-737	2	56	the	the	DET
admet-737	2	57	modern	modern	ADJ
admet-737	2	58	drug	drug	NOUN
admet-737	2	59	discovery	discovery	NOUN
admet-737	2	60	process	process	NOUN
admet-737	2	61	.	.	PUNCT
admet-737	3	1	the	the	DET
admet-737	3	2	speed	speed	NOUN
admet-737	3	3	of	of	ADP
admet-737	3	4	traditional	traditional	ADJ
admet-737	3	5	analyses	analysis	NOUN
admet-737	3	6	and	and	CCONJ
admet-737	3	7	limited	limited	ADJ
admet-737	3	8	quantities	quantity	NOUN
admet-737	3	9	of	of	ADP
admet-737	3	10	hit	hit	VERB
admet-737	3	11	molecules	molecule	NOUN
admet-737	3	12	are	be	AUX
admet-737	3	13	obstacles	obstacle	NOUN
admet-737	3	14	for	for	ADP
admet-737	3	15	efficient	efficient	ADJ
admet-737	3	16	acquisition	acquisition	NOUN
admet-737	3	17	of	of	ADP
admet-737	3	18	experimental	experimental	ADJ
admet-737	3	19	data	datum	NOUN
admet-737	3	20	.	.	PUNCT
admet-737	4	1	herein	herein	PROPN
admet-737	4	2	,	,	PUNCT
admet-737	4	3	the	the	DET
admet-737	4	4	range	range	NOUN
admet-737	4	5	of	of	ADP
admet-737	4	6	applications	application	NOUN
admet-737	4	7	of	of	ADP
admet-737	4	8	quantitative	quantitative	ADJ
admet-737	4	9	nuclear	nuclear	ADJ
admet-737	4	10	magnetic	magnetic	ADJ
admet-737	4	11	resonance	resonance	NOUN
admet-737	4	12	(	(	PUNCT
admet-737	4	13	nmr	nmr	NOUN
admet-737	4	14	)	)	PUNCT
admet-737	4	15	spectroscopy	spectroscopy	NOUN
admet-737	4	16	as	as	ADP
admet-737	4	17	a	a	DET
admet-737	4	18	fast	fast	ADJ
admet-737	4	19	technique	technique	NOUN
admet-737	4	20	used	use	VERB
admet-737	4	21	to	to	PART
admet-737	4	22	evaluate	evaluate	VERB
admet-737	4	23	solubility	solubility	NOUN
admet-737	4	24	,	,	PUNCT
admet-737	4	25	log	log	VERB
admet-737	4	26	p	p	NOUN
admet-737	4	27	and	and	CCONJ
admet-737	4	28	pka	pka	PROPN
admet-737	4	29	are	be	AUX
admet-737	4	30	discussed	discuss	VERB
admet-737	4	31	.	.	PUNCT
admet-737	5	1	keywords	keyword	NOUN
admet-737	5	2	logp	logp	VERB
admet-737	5	3	;	;	PUNCT
admet-737	5	4	qnmr	qnmr	NOUN
admet-737	5	5	;	;	PUNCT
admet-737	5	6	drug	drug	NOUN
admet-737	5	7	solubility	solubility	NOUN
admet-737	5	8	;	;	PUNCT
admet-737	5	9	dosy	dosy	NOUN
admet-737	5	10	;	;	PUNCT
admet-737	5	11	pharmaceutical	pharmaceutical	NOUN
admet-737	5	12	formulations	formulation	NOUN
admet-737	5	13	.	.	PUNCT
admet-737	6	1	introduction	introduction	NOUN
admet-737	6	2	the	the	DET
admet-737	6	3	process	process	NOUN
admet-737	6	4	of	of	ADP
admet-737	6	5	modern	modern	ADJ
admet-737	6	6	drug	drug	NOUN
admet-737	6	7	discovery	discovery	NOUN
admet-737	6	8	and	and	CCONJ
admet-737	6	9	development	development	NOUN
admet-737	6	10	is	be	AUX
admet-737	6	11	highly	highly	ADV
admet-737	6	12	complex	complex	ADJ
admet-737	6	13	process	process	NOUN
admet-737	6	14	that	that	PRON
admet-737	6	15	aims	aim	VERB
admet-737	6	16	to	to	PART
admet-737	6	17	create	create	VERB
admet-737	6	18	new	new	ADJ
admet-737	6	19	medicines	medicine	NOUN
admet-737	6	20	that	that	PRON
admet-737	6	21	meet	meet	VERB
admet-737	6	22	stringent	stringent	ADJ
admet-737	6	23	requirements	requirement	NOUN
admet-737	6	24	set	set	VERB
admet-737	6	25	by	by	ADP
admet-737	6	26	governmental	governmental	ADJ
admet-737	6	27	bodies	body	NOUN
admet-737	6	28	,	,	PUNCT
admet-737	6	29	such	such	ADJ
admet-737	6	30	as	as	ADP
admet-737	6	31	food	food	NOUN
admet-737	6	32	and	and	CCONJ
admet-737	6	33	drug	drug	PROPN
admet-737	6	34	administration	administration	PROPN
admet-737	6	35	(	(	PUNCT
admet-737	6	36	fda	fda	PROPN
admet-737	6	37	)	)	PUNCT
admet-737	6	38	in	in	ADP
admet-737	6	39	the	the	DET
admet-737	6	40	usa	usa	PROPN
admet-737	6	41	,	,	PUNCT
admet-737	6	42	european	european	PROPN
admet-737	6	43	medicines	medicine	NOUN
admet-737	6	44	agency	agency	NOUN
admet-737	6	45	(	(	PUNCT
admet-737	6	46	ema	ema	PROPN
admet-737	6	47	)	)	PUNCT
admet-737	6	48	and	and	CCONJ
admet-737	6	49	others	other	NOUN
admet-737	6	50	around	around	ADP
admet-737	6	51	the	the	DET
admet-737	6	52	world	world	NOUN
admet-737	7	1	[	[	X
admet-737	7	2	1	1	NUM
admet-737	7	3	]	]	PUNCT
admet-737	7	4	.	.	PUNCT
admet-737	8	1	efforts	effort	NOUN
admet-737	8	2	of	of	ADP
admet-737	8	3	the	the	DET
admet-737	8	4	industry	industry	NOUN
admet-737	8	5	have	have	AUX
admet-737	8	6	already	already	ADV
admet-737	8	7	heavily	heavily	ADV
admet-737	8	8	utilized	utilize	VERB
admet-737	8	9	most	most	ADJ
admet-737	8	10	of	of	ADP
admet-737	8	11	the	the	DET
admet-737	8	12	easiest	easy	ADJ
admet-737	8	13	disease	disease	NOUN
admet-737	8	14	targets	target	NOUN
admet-737	8	15	,	,	PUNCT
admet-737	8	16	which	which	PRON
admet-737	8	17	reduces	reduce	VERB
admet-737	8	18	the	the	DET
admet-737	8	19	chances	chance	NOUN
admet-737	8	20	of	of	ADP
admet-737	8	21	serendipity	serendipity	NOUN
admet-737	8	22	in	in	ADP
admet-737	8	23	discovery	discovery	NOUN
admet-737	8	24	of	of	ADP
admet-737	8	25	new	new	ADJ
admet-737	8	26	therapeutic	therapeutic	ADJ
admet-737	8	27	agents	agent	NOUN
admet-737	8	28	.	.	PUNCT
admet-737	9	1	this	this	PRON
admet-737	9	2	requires	require	VERB
admet-737	9	3	systematic	systematic	ADJ
admet-737	9	4	approaches	approach	NOUN
admet-737	9	5	in	in	ADP
admet-737	9	6	identifying	identify	VERB
admet-737	9	7	new	new	ADJ
admet-737	9	8	targets	target	NOUN
admet-737	9	9	or	or	CCONJ
admet-737	9	10	paradigm	paradigm	NOUN
admet-737	9	11	shift	shift	NOUN
admet-737	9	12	in	in	ADP
admet-737	9	13	finding	find	VERB
admet-737	9	14	novel	novel	ADJ
admet-737	9	15	lead	lead	NOUN
admet-737	9	16	molecules	molecule	NOUN
admet-737	9	17	,	,	PUNCT
admet-737	9	18	resulting	result	VERB
admet-737	9	19	in	in	ADP
admet-737	9	20	the	the	DET
admet-737	9	21	need	need	NOUN
admet-737	9	22	for	for	ADP
admet-737	9	23	iterative	iterative	NOUN
admet-737	9	24	,	,	PUNCT
admet-737	9	25	tedious	tedious	ADJ
admet-737	9	26	and	and	CCONJ
admet-737	9	27	quite	quite	ADV
admet-737	9	28	often	often	ADV
admet-737	9	29	expensive	expensive	ADJ
admet-737	9	30	multidisciplinary	multidisciplinary	ADJ
admet-737	9	31	processes	process	NOUN
admet-737	9	32	.	.	PUNCT
admet-737	10	1	although	although	SCONJ
admet-737	10	2	the	the	DET
admet-737	10	3	record	record	NOUN
admet-737	10	4	breaking	break	VERB
admet-737	10	5	number	number	NOUN
admet-737	10	6	of	of	ADP
admet-737	10	7	59	59	NUM
admet-737	10	8	drugs	drug	NOUN
admet-737	10	9	,	,	PUNCT
admet-737	10	10	including	include	VERB
admet-737	10	11	17	17	NUM
admet-737	10	12	biologics	biologic	NOUN
admet-737	10	13	,	,	PUNCT
admet-737	10	14	were	be	AUX
admet-737	10	15	approved	approve	VERB
admet-737	10	16	by	by	ADP
admet-737	10	17	fda	fda	PROPN
admet-737	10	18	in	in	ADP
admet-737	10	19	2018	2018	NUM
admet-737	11	1	[	[	X
admet-737	11	2	2	2	NUM
admet-737	11	3	]	]	PUNCT
admet-737	11	4	,	,	PUNCT
admet-737	11	5	the	the	DET
admet-737	11	6	high	high	ADJ
admet-737	11	7	failure	failure	NOUN
admet-737	11	8	rates	rate	NOUN
admet-737	11	9	of	of	ADP
admet-737	11	10	clinical	clinical	ADJ
admet-737	11	11	candidates	candidate	NOUN
admet-737	11	12	frustrates	frustrate	VERB
admet-737	11	13	pharmaceutical	pharmaceutical	ADJ
admet-737	11	14	industry	industry	NOUN
admet-737	11	15	and	and	CCONJ
admet-737	11	16	academic	academic	ADJ
admet-737	11	17	research	research	NOUN
admet-737	11	18	groups	group	NOUN
admet-737	11	19	.	.	PUNCT
admet-737	12	1	it	it	PRON
admet-737	12	2	is	be	AUX
admet-737	12	3	shown	show	VERB
admet-737	12	4	that	that	SCONJ
admet-737	12	5	safety	safety	NOUN
admet-737	12	6	issues	issue	NOUN
admet-737	12	7	are	be	AUX
admet-737	12	8	linked	link	VERB
admet-737	12	9	to	to	ADP
admet-737	12	10	off	off	ADP
admet-737	12	11	-	-	PUNCT
admet-737	12	12	target	target	VERB
admet-737	12	13	interactions	interaction	NOUN
admet-737	12	14	of	of	ADP
admet-737	12	15	these	these	DET
admet-737	12	16	compounds	compound	NOUN
admet-737	13	1	[	[	X
admet-737	13	2	3	3	NUM
admet-737	13	3	]	]	PUNCT
admet-737	13	4	or	or	CCONJ
admet-737	13	5	their	their	PRON
admet-737	13	6	physico	physico	NOUN
admet-737	13	7	-	-	PUNCT
admet-737	13	8	chemical	chemical	NOUN
admet-737	13	9	properties	property	NOUN
admet-737	13	10	[	[	X
admet-737	13	11	4	4	NUM
admet-737	13	12	]	]	PUNCT
admet-737	13	13	.	.	PUNCT
admet-737	14	1	therefore	therefore	ADV
admet-737	14	2	,	,	PUNCT
admet-737	14	3	pharmaceutical	pharmaceutical	ADJ
admet-737	14	4	industry	industry	NOUN
admet-737	14	5	was	be	AUX
admet-737	14	6	focused	focus	VERB
admet-737	14	7	on	on	ADP
admet-737	14	8	the	the	DET
admet-737	14	9	drug	drug	NOUN
admet-737	14	10	likeness	likeness	NOUN
admet-737	14	11	properties	property	NOUN
admet-737	14	12	of	of	ADP
admet-737	14	13	drug	drug	NOUN
admet-737	14	14	candidates	candidate	NOUN
admet-737	14	15	in	in	ADP
admet-737	14	16	recent	recent	ADJ
admet-737	14	17	years	year	NOUN
admet-737	14	18	.	.	PUNCT
admet-737	15	1	absorption	absorption	NOUN
admet-737	15	2	,	,	PUNCT
admet-737	15	3	distribution	distribution	NOUN
admet-737	15	4	,	,	PUNCT
admet-737	15	5	metabolism	metabolism	NOUN
admet-737	15	6	,	,	PUNCT
admet-737	15	7	excretion	excretion	NOUN
admet-737	15	8	,	,	PUNCT
admet-737	15	9	and	and	CCONJ
admet-737	15	10	toxicity	toxicity	NOUN
admet-737	15	11	(	(	PUNCT
admet-737	15	12	admet	admet	NOUN
admet-737	15	13	)	)	PUNCT
admet-737	15	14	properties	property	NOUN
admet-737	15	15	are	be	AUX
admet-737	15	16	generally	generally	ADV
admet-737	15	17	included	include	VERB
admet-737	15	18	as	as	ADP
admet-737	15	19	filters	filter	NOUN
admet-737	15	20	during	during	ADP
admet-737	15	21	process	process	NOUN
admet-737	15	22	of	of	ADP
admet-737	15	23	identification	identification	NOUN
admet-737	15	24	of	of	ADP
admet-737	15	25	hit	hit	VERB
admet-737	15	26	molecules	molecule	NOUN
admet-737	15	27	or	or	CCONJ
admet-737	15	28	a	a	DET
admet-737	15	29	guide	guide	NOUN
admet-737	15	30	in	in	ADP
admet-737	15	31	the	the	DET
admet-737	15	32	design	design	NOUN
admet-737	15	33	or	or	CCONJ
admet-737	15	34	modifications	modification	NOUN
admet-737	15	35	of	of	ADP
admet-737	15	36	lead	lead	ADJ
admet-737	15	37	molecules	molecule	NOUN
admet-737	15	38	.	.	PUNCT
admet-737	16	1	a	a	DET
admet-737	16	2	significant	significant	ADJ
admet-737	16	3	progress	progress	NOUN
admet-737	16	4	was	be	AUX
admet-737	16	5	achieved	achieve	VERB
admet-737	16	6	in	in	ADP
admet-737	16	7	prediction	prediction	NOUN
admet-737	16	8	of	of	ADP
admet-737	16	9	admet	admet	NOUN
admet-737	16	10	properties	property	NOUN
admet-737	16	11	using	use	VERB
admet-737	16	12	in	in	ADP
admet-737	16	13	silico	silico	NOUN
admet-737	16	14	methods	method	NOUN
admet-737	16	15	and	and	CCONJ
admet-737	16	16	these	these	DET
admet-737	16	17	approaches	approach	NOUN
admet-737	16	18	are	be	AUX
admet-737	16	19	generally	generally	ADV
admet-737	16	20	cheaper	cheap	ADJ
admet-737	16	21	and	and	CCONJ
admet-737	16	22	greener	green	ADJ
admet-737	16	23	when	when	SCONJ
admet-737	16	24	compared	compare	VERB
admet-737	16	25	to	to	ADP
admet-737	16	26	their	their	PRON
admet-737	16	27	experimental	experimental	ADJ
admet-737	16	28	determination	determination	NOUN
admet-737	16	29	[	[	X
admet-737	16	30	5	5	NUM
admet-737	16	31	]	]	PUNCT
admet-737	16	32	.	.	PUNCT
admet-737	17	1	although	although	SCONJ
admet-737	17	2	these	these	DET
admet-737	17	3	methods	method	NOUN
admet-737	17	4	can	can	AUX
admet-737	17	5	be	be	AUX
admet-737	17	6	used	use	VERB
admet-737	17	7	in	in	ADP
admet-737	17	8	virtual	virtual	ADJ
admet-737	17	9	high	high	ADJ
admet-737	17	10	throughput	throughput	NOUN
admet-737	17	11	screening	screen	VERB
admet-737	17	12	as	as	ADP
admet-737	17	13	filtering	filter	VERB
admet-737	17	14	steps	step	NOUN
admet-737	17	15	,	,	PUNCT
admet-737	17	16	they	they	PRON
admet-737	17	17	are	be	AUX
admet-737	17	18	often	often	ADV
admet-737	17	19	limited	limit	VERB
admet-737	17	20	by	by	ADP
admet-737	17	21	their	their	PRON
admet-737	17	22	applicability	applicability	NOUN
admet-737	17	23	domains	domain	NOUN
admet-737	17	24	,	,	PUNCT
admet-737	17	25	as	as	ADP
admet-737	17	26	prediction	prediction	NOUN
admet-737	17	27	of	of	ADP
admet-737	17	28	admet	admet	ADJ
admet-737	17	29	molecules	molecule	NOUN
admet-737	17	30	with	with	ADP
admet-737	17	31	novel	novel	ADJ
admet-737	17	32	http://dx.doi.org/10.5599/admet.737	http://dx.doi.org/10.5599/admet.737	VERB
admet-737	17	33	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-737	17	34	admet	admet	PROPN
admet-737	17	35	&	&	CCONJ
admet-737	17	36	dmpk	dmpk	PROPN
admet-737	17	37	7(4	7(4	NUM
admet-737	17	38	)	)	PUNCT
admet-737	17	39	(	(	PUNCT
admet-737	17	40	2019	2019	NUM
admet-737	17	41	)	)	PUNCT
admet-737	17	42	242	242	NUM
admet-737	17	43	-	-	SYM
admet-737	17	44	251	251	NUM
admet-737	17	45	nmr	nmr	NOUN
admet-737	17	46	spectroscopy	spectroscopy	NOUN
admet-737	17	47	in	in	ADP
admet-737	17	48	drug	drug	NOUN
admet-737	17	49	discovery	discovery	NOUN
admet-737	17	50	and	and	CCONJ
admet-737	17	51	development	development	NOUN
admet-737	17	52	doi	doi	PROPN
admet-737	17	53	:	:	PUNCT
admet-737	17	54	10.5599	10.5599	NUM
admet-737	17	55	/	/	SYM
admet-737	17	56	admet.737	admet.737	PROPN
admet-737	17	57	243	243	NUM
admet-737	17	58	scaffolds	scaffold	NOUN
admet-737	17	59	outside	outside	ADV
admet-737	17	60	of	of	ADP
admet-737	17	61	chemical	chemical	ADJ
admet-737	17	62	space	space	NOUN
admet-737	17	63	of	of	ADP
admet-737	17	64	training	training	NOUN
admet-737	17	65	sets	set	NOUN
admet-737	17	66	may	may	AUX
admet-737	17	67	not	not	PART
admet-737	17	68	be	be	AUX
admet-737	17	69	reliable	reliable	ADJ
admet-737	17	70	.	.	PUNCT
admet-737	18	1	most	most	ADV
admet-737	18	2	relevant	relevant	ADJ
admet-737	18	3	assessments	assessment	NOUN
admet-737	18	4	of	of	ADP
admet-737	18	5	compounds	compound	NOUN
admet-737	18	6	properties	property	NOUN
admet-737	18	7	can	can	AUX
admet-737	18	8	be	be	AUX
admet-737	18	9	achieved	achieve	VERB
admet-737	18	10	by	by	ADP
admet-737	18	11	employing	employ	VERB
admet-737	18	12	in	in	ADP
admet-737	18	13	vivo	vivo	ADJ
admet-737	18	14	assays	assay	NOUN
admet-737	18	15	,	,	PUNCT
admet-737	18	16	often	often	ADV
admet-737	18	17	preceded	precede	VERB
admet-737	18	18	by	by	ADP
admet-737	18	19	in	in	ADP
admet-737	18	20	vitro	vitro	X
admet-737	18	21	experiments	experiment	NOUN
admet-737	18	22	as	as	ADP
admet-737	18	23	indicators	indicator	NOUN
admet-737	18	24	of	of	ADP
admet-737	18	25	their	their	PRON
admet-737	18	26	adme	adme	NOUN
admet-737	18	27	fate	fate	NOUN
admet-737	19	1	[	[	X
admet-737	19	2	6	6	NUM
admet-737	19	3	]	]	PUNCT
admet-737	19	4	.	.	PUNCT
admet-737	20	1	such	such	ADJ
admet-737	20	2	two	two	NUM
admet-737	20	3	-	-	PUNCT
admet-737	20	4	tier	tier	NOUN
admet-737	20	5	approaches	approach	NOUN
admet-737	20	6	can	can	AUX
admet-737	20	7	not	not	PART
admet-737	20	8	always	always	ADV
admet-737	20	9	be	be	AUX
admet-737	20	10	employed	employ	VERB
admet-737	20	11	for	for	ADP
admet-737	20	12	large	large	ADJ
admet-737	20	13	number	number	NOUN
admet-737	20	14	of	of	ADP
admet-737	20	15	compounds	compound	NOUN
admet-737	20	16	or	or	CCONJ
admet-737	20	17	in	in	ADP
admet-737	20	18	a	a	DET
admet-737	20	19	high	high	ADJ
admet-737	20	20	throughput	throughput	NOUN
admet-737	20	21	manner	manner	NOUN
admet-737	20	22	,	,	PUNCT
admet-737	20	23	which	which	PRON
admet-737	20	24	demands	demand	VERB
admet-737	20	25	utilization	utilization	NOUN
admet-737	20	26	of	of	ADP
admet-737	20	27	biophysical	biophysical	ADJ
admet-737	20	28	techniques	technique	NOUN
admet-737	20	29	and	and	CCONJ
admet-737	20	30	development	development	NOUN
admet-737	20	31	of	of	ADP
admet-737	20	32	novel	novel	ADJ
admet-737	20	33	assays	assay	NOUN
admet-737	20	34	to	to	PART
admet-737	20	35	evaluate	evaluate	VERB
admet-737	20	36	physico	physico	NOUN
admet-737	20	37	-	-	PUNCT
admet-737	20	38	chemical	chemical	NOUN
admet-737	20	39	characteristics	characteristic	NOUN
admet-737	20	40	in	in	ADP
admet-737	20	41	relation	relation	NOUN
admet-737	20	42	to	to	ADP
admet-737	20	43	admet	admet	PROPN
admet-737	20	44	properties	property	NOUN
admet-737	20	45	.	.	PUNCT
admet-737	21	1	significant	significant	ADJ
admet-737	21	2	progress	progress	NOUN
admet-737	21	3	has	have	AUX
admet-737	21	4	been	be	AUX
admet-737	21	5	achieved	achieve	VERB
admet-737	21	6	in	in	ADP
admet-737	21	7	utilization	utilization	NOUN
admet-737	21	8	of	of	ADP
admet-737	21	9	chromatography	chromatography	NOUN
admet-737	21	10	to	to	PART
admet-737	21	11	measure	measure	VERB
admet-737	21	12	lipophilicity	lipophilicity	NOUN
admet-737	21	13	of	of	ADP
admet-737	21	14	compounds	compound	NOUN
admet-737	21	15	and	and	CCONJ
admet-737	21	16	their	their	PRON
admet-737	21	17	biomimetic	biomimetic	ADJ
admet-737	21	18	properties	property	NOUN
admet-737	21	19	[	[	X
admet-737	21	20	7,8	7,8	NUM
admet-737	21	21	]	]	PUNCT
admet-737	21	22	,	,	PUNCT
admet-737	21	23	as	as	ADV
admet-737	21	24	well	well	ADV
admet-737	21	25	as	as	ADP
admet-737	21	26	to	to	PART
admet-737	21	27	evaluate	evaluate	VERB
admet-737	21	28	their	their	PRON
admet-737	21	29	polarity	polarity	NOUN
admet-737	21	30	,	,	PUNCT
admet-737	21	31	conformational	conformational	ADJ
admet-737	21	32	states	state	NOUN
admet-737	21	33	and	and	CCONJ
admet-737	21	34	intramolecular	intramolecular	ADJ
admet-737	21	35	hydrogen	hydrogen	NOUN
admet-737	21	36	bonds	bond	NOUN
admet-737	21	37	[	[	X
admet-737	21	38	9	9	NUM
admet-737	21	39	]	]	PUNCT
admet-737	21	40	.	.	PUNCT
admet-737	22	1	the	the	DET
admet-737	22	2	development	development	NOUN
admet-737	22	3	of	of	ADP
admet-737	22	4	great	great	ADJ
admet-737	22	5	variety	variety	NOUN
admet-737	22	6	of	of	ADP
admet-737	22	7	chromatographic	chromatographic	ADJ
admet-737	22	8	methods	method	NOUN
admet-737	22	9	is	be	AUX
admet-737	22	10	the	the	DET
admet-737	22	11	result	result	NOUN
admet-737	22	12	of	of	ADP
admet-737	22	13	possibility	possibility	NOUN
admet-737	22	14	to	to	PART
admet-737	22	15	utilize	utilize	VERB
admet-737	22	16	a	a	DET
admet-737	22	17	range	range	NOUN
admet-737	22	18	of	of	ADP
admet-737	22	19	stationary	stationary	ADJ
admet-737	22	20	phases	phase	NOUN
admet-737	22	21	and	and	CCONJ
admet-737	22	22	to	to	PART
admet-737	22	23	vary	vary	VERB
admet-737	22	24	mobile	mobile	ADJ
admet-737	22	25	phases	phase	NOUN
admet-737	22	26	to	to	PART
admet-737	22	27	represent	represent	VERB
admet-737	22	28	different	different	ADJ
admet-737	22	29	parts	part	NOUN
admet-737	22	30	of	of	ADP
admet-737	22	31	biological	biological	ADJ
admet-737	22	32	systems	system	NOUN
admet-737	22	33	[	[	X
admet-737	22	34	8	8	NUM
admet-737	22	35	]	]	PUNCT
admet-737	22	36	,	,	PUNCT
admet-737	22	37	while	while	SCONJ
admet-737	22	38	the	the	DET
admet-737	22	39	automation	automation	NOUN
admet-737	22	40	increases	increase	VERB
admet-737	22	41	the	the	DET
admet-737	22	42	throughput	throughput	NOUN
admet-737	22	43	of	of	ADP
admet-737	22	44	analysis	analysis	NOUN
admet-737	22	45	.	.	PUNCT
admet-737	23	1	on	on	ADP
admet-737	23	2	the	the	DET
admet-737	23	3	contrary	contrary	NOUN
admet-737	23	4	,	,	PUNCT
admet-737	23	5	nuclear	nuclear	ADJ
admet-737	23	6	magnetic	magnetic	ADJ
admet-737	23	7	spectroscopy	spectroscopy	NOUN
admet-737	23	8	(	(	PUNCT
admet-737	23	9	nmr	nmr	NOUN
admet-737	23	10	)	)	PUNCT
admet-737	23	11	spectroscopy	spectroscopy	NOUN
admet-737	23	12	is	be	AUX
admet-737	23	13	not	not	PART
admet-737	23	14	readily	readily	ADV
admet-737	23	15	associated	associate	VERB
admet-737	23	16	with	with	ADP
admet-737	23	17	measuring	measure	VERB
admet-737	23	18	admet	admet	NOUN
admet-737	23	19	properties	property	NOUN
admet-737	23	20	.	.	PUNCT
admet-737	24	1	up	up	ADP
admet-737	24	2	to	to	ADP
admet-737	24	3	date	date	NOUN
admet-737	24	4	,	,	PUNCT
admet-737	24	5	the	the	DET
admet-737	24	6	scopus	scopus	NOUN
admet-737	24	7	search	search	NOUN
admet-737	24	8	using	use	VERB
admet-737	24	9	keyword	keyword	NOUN
admet-737	24	10	“	"	PUNCT
admet-737	24	11	nmr	nmr	NOUN
admet-737	24	12	”	"	PUNCT
admet-737	24	13	in	in	ADP
admet-737	24	14	conjunction	conjunction	NOUN
admet-737	24	15	with	with	ADP
admet-737	24	16	“	"	PUNCT
admet-737	24	17	adme	adme	NOUN
admet-737	24	18	”	"	PUNCT
admet-737	24	19	results	result	NOUN
admet-737	24	20	in	in	ADP
admet-737	24	21	125	125	NUM
admet-737	24	22	records	record	NOUN
admet-737	24	23	,	,	PUNCT
admet-737	24	24	which	which	PRON
admet-737	24	25	is	be	AUX
admet-737	24	26	significantly	significantly	ADV
admet-737	24	27	lower	low	ADJ
admet-737	24	28	when	when	SCONJ
admet-737	24	29	compared	compare	VERB
admet-737	24	30	to	to	ADP
admet-737	24	31	456	456	NUM
admet-737	24	32	when	when	SCONJ
admet-737	24	33	the	the	DET
admet-737	24	34	“	"	PUNCT
admet-737	24	35	chromatography	chromatography	NOUN
admet-737	24	36	”	"	PUNCT
admet-737	24	37	keyword	keyword	NOUN
admet-737	24	38	is	be	AUX
admet-737	24	39	used	use	VERB
admet-737	24	40	.	.	PUNCT
admet-737	25	1	this	this	PRON
admet-737	25	2	may	may	AUX
admet-737	25	3	be	be	AUX
admet-737	25	4	a	a	DET
admet-737	25	5	consequence	consequence	NOUN
admet-737	25	6	that	that	SCONJ
admet-737	25	7	nmr	nmr	NOUN
admet-737	25	8	requires	require	VERB
admet-737	25	9	expensive	expensive	ADJ
admet-737	25	10	instrumentation	instrumentation	NOUN
admet-737	25	11	and	and	CCONJ
admet-737	25	12	samples	sample	NOUN
admet-737	25	13	are	be	AUX
admet-737	25	14	generally	generally	ADV
admet-737	25	15	dissolved	dissolve	VERB
admet-737	25	16	in	in	ADP
admet-737	25	17	deuterated	deuterate	VERB
admet-737	25	18	solvents	solvent	NOUN
admet-737	25	19	at	at	ADP
admet-737	25	20	concentrations	concentration	NOUN
admet-737	25	21	that	that	PRON
admet-737	25	22	may	may	AUX
admet-737	25	23	be	be	AUX
admet-737	25	24	considerably	considerably	ADV
admet-737	25	25	higher	high	ADJ
admet-737	25	26	than	than	ADP
admet-737	25	27	those	those	PRON
admet-737	25	28	observed	observe	VERB
admet-737	25	29	in	in	ADP
admet-737	25	30	physiological	physiological	ADJ
admet-737	25	31	conditions	condition	NOUN
admet-737	25	32	.	.	PUNCT
admet-737	26	1	therefore	therefore	ADV
admet-737	26	2	,	,	PUNCT
admet-737	26	3	this	this	DET
admet-737	26	4	spectroscopic	spectroscopic	ADJ
admet-737	26	5	technique	technique	NOUN
admet-737	26	6	is	be	AUX
admet-737	26	7	mainly	mainly	ADV
admet-737	26	8	utilized	utilize	VERB
admet-737	26	9	to	to	PART
admet-737	26	10	acquire	acquire	VERB
admet-737	26	11	qualitative	qualitative	ADJ
admet-737	26	12	information	information	NOUN
admet-737	26	13	on	on	ADP
admet-737	26	14	molecular	molecular	ADJ
admet-737	26	15	structure	structure	NOUN
admet-737	26	16	of	of	ADP
admet-737	26	17	organic	organic	ADJ
admet-737	26	18	compounds	compound	NOUN
admet-737	26	19	as	as	ADV
admet-737	26	20	well	well	ADV
admet-737	26	21	as	as	ADP
admet-737	26	22	biopolymers	biopolymer	NOUN
admet-737	26	23	,	,	PUNCT
admet-737	26	24	or	or	CCONJ
admet-737	26	25	for	for	ADP
admet-737	26	26	the	the	DET
admet-737	26	27	assessment	assessment	NOUN
admet-737	26	28	of	of	ADP
admet-737	26	29	the	the	DET
admet-737	26	30	sample	sample	NOUN
admet-737	26	31	purity	purity	NOUN
admet-737	26	32	.	.	PUNCT
admet-737	27	1	however	however	ADV
admet-737	27	2	,	,	PUNCT
admet-737	27	3	nmr	nmr	NOUN
admet-737	27	4	can	can	AUX
admet-737	27	5	also	also	ADV
admet-737	27	6	provide	provide	VERB
admet-737	27	7	information	information	NOUN
admet-737	27	8	on	on	ADP
admet-737	27	9	three	three	NUM
admet-737	27	10	dimensional	dimensional	ADJ
admet-737	27	11	(	(	PUNCT
admet-737	27	12	3d	3d	NOUN
admet-737	27	13	)	)	PUNCT
admet-737	27	14	structures	structure	NOUN
admet-737	27	15	at	at	ADP
admet-737	27	16	atomic	atomic	ADJ
admet-737	27	17	level	level	NOUN
admet-737	27	18	resolution	resolution	NOUN
admet-737	27	19	of	of	ADP
admet-737	27	20	pure	pure	ADJ
admet-737	27	21	samples	sample	NOUN
admet-737	27	22	and	and	CCONJ
admet-737	27	23	mixtures	mixture	NOUN
admet-737	27	24	,	,	PUNCT
admet-737	27	25	with	with	ADP
admet-737	27	26	a	a	DET
admet-737	27	27	possibility	possibility	NOUN
admet-737	27	28	to	to	PART
admet-737	27	29	detect	detect	VERB
admet-737	27	30	and	and	CCONJ
admet-737	27	31	even	even	ADV
admet-737	27	32	quantify	quantify	VERB
admet-737	27	33	intermolecular	intermolecular	ADJ
admet-737	27	34	interactions	interaction	NOUN
admet-737	27	35	as	as	ADP
admet-737	27	36	dynamic	dynamic	ADJ
admet-737	27	37	processes	process	NOUN
admet-737	27	38	,	,	PUNCT
admet-737	27	39	making	make	VERB
admet-737	27	40	this	this	DET
admet-737	27	41	techniques	technique	NOUN
admet-737	27	42	versatile	versatile	ADJ
admet-737	27	43	and	and	CCONJ
admet-737	27	44	applicable	applicable	ADJ
admet-737	27	45	to	to	ADP
admet-737	27	46	different	different	ADJ
admet-737	27	47	stages	stage	NOUN
admet-737	27	48	in	in	ADP
admet-737	27	49	the	the	DET
admet-737	27	50	search	search	NOUN
admet-737	27	51	for	for	ADP
admet-737	27	52	new	new	ADJ
admet-737	27	53	therapeutic	therapeutic	ADJ
admet-737	27	54	agents	agent	NOUN
admet-737	27	55	[	[	X
admet-737	27	56	10	10	NUM
admet-737	27	57	]	]	PUNCT
admet-737	27	58	.	.	PUNCT
admet-737	28	1	therefore	therefore	ADV
admet-737	28	2	,	,	PUNCT
admet-737	28	3	despite	despite	SCONJ
admet-737	28	4	its	its	PRON
admet-737	28	5	disadvantages	disadvantage	NOUN
admet-737	28	6	,	,	PUNCT
admet-737	28	7	nmr	nmr	NOUN
admet-737	28	8	spectroscopy	spectroscopy	NOUN
admet-737	28	9	plays	play	VERB
admet-737	28	10	a	a	DET
admet-737	28	11	significant	significant	ADJ
admet-737	28	12	role	role	NOUN
admet-737	28	13	in	in	ADP
admet-737	28	14	the	the	DET
admet-737	28	15	drug	drug	NOUN
admet-737	28	16	discovery	discovery	NOUN
admet-737	28	17	and	and	CCONJ
admet-737	28	18	development	development	NOUN
admet-737	28	19	processes	process	NOUN
admet-737	28	20	.	.	PUNCT
admet-737	29	1	some	some	PRON
admet-737	29	2	of	of	ADP
admet-737	29	3	these	these	DET
admet-737	29	4	applications	application	NOUN
admet-737	29	5	include	include	VERB
admet-737	29	6	:	:	PUNCT
admet-737	29	7	protein	protein	NOUN
admet-737	29	8	structure	structure	NOUN
admet-737	29	9	determination	determination	NOUN
admet-737	29	10	in	in	ADP
admet-737	29	11	solution	solution	NOUN
admet-737	29	12	[	[	X
admet-737	29	13	11	11	NUM
admet-737	29	14	]	]	PUNCT
admet-737	29	15	or	or	CCONJ
admet-737	29	16	target	target	VERB
admet-737	29	17	structure	structure	NOUN
admet-737	29	18	validation	validation	NOUN
admet-737	29	19	in	in	ADP
admet-737	29	20	presence	presence	NOUN
admet-737	29	21	of	of	ADP
admet-737	29	22	membranes	membrane	NOUN
admet-737	29	23	[	[	X
admet-737	29	24	12	12	NUM
admet-737	29	25	]	]	PUNCT
admet-737	29	26	,	,	PUNCT
admet-737	29	27	enabling	enable	VERB
admet-737	29	28	structure	structure	NOUN
admet-737	29	29	-	-	PUNCT
admet-737	29	30	based	base	VERB
admet-737	29	31	drug	drug	NOUN
admet-737	29	32	discovery	discovery	NOUN
admet-737	29	33	in	in	ADP
admet-737	29	34	solution	solution	NOUN
admet-737	29	35	[	[	X
admet-737	29	36	13,14	13,14	X
admet-737	29	37	]	]	X
admet-737	29	38	or	or	CCONJ
admet-737	29	39	in	in	ADP
admet-737	29	40	-	-	PUNCT
admet-737	29	41	cell	cell	NOUN
admet-737	29	42	[	[	X
admet-737	29	43	15	15	NUM
admet-737	29	44	]	]	PUNCT
admet-737	29	45	,	,	PUNCT
admet-737	29	46	identification	identification	NOUN
admet-737	29	47	of	of	ADP
admet-737	29	48	hit	hit	VERB
admet-737	29	49	compounds	compound	NOUN
admet-737	29	50	[	[	X
admet-737	29	51	16	16	NUM
admet-737	29	52	]	]	PUNCT
admet-737	29	53	and	and	CCONJ
admet-737	29	54	determination	determination	NOUN
admet-737	29	55	of	of	ADP
admet-737	29	56	their	their	PRON
admet-737	29	57	conformations	conformation	NOUN
admet-737	29	58	[	[	X
admet-737	29	59	17	17	NUM
admet-737	29	60	]	]	PUNCT
admet-737	29	61	,	,	PUNCT
admet-737	29	62	development	development	NOUN
admet-737	29	63	of	of	ADP
admet-737	29	64	biopharmaceutical	biopharmaceutical	ADJ
admet-737	29	65	formulations	formulation	NOUN
admet-737	29	66	[	[	X
admet-737	29	67	18	18	NUM
admet-737	29	68	]	]	PUNCT
admet-737	29	69	,	,	PUNCT
admet-737	29	70	and	and	CCONJ
admet-737	29	71	evaluation	evaluation	NOUN
admet-737	29	72	of	of	ADP
admet-737	29	73	drug	drug	NOUN
admet-737	29	74	metabolism	metabolism	NOUN
admet-737	29	75	and	and	CCONJ
admet-737	29	76	toxicity	toxicity	NOUN
admet-737	29	77	in	in	ADP
admet-737	29	78	patients	patient	NOUN
admet-737	29	79	[	[	X
admet-737	29	80	19,20	19,20	X
admet-737	29	81	]	]	PUNCT
admet-737	29	82	that	that	PRON
admet-737	29	83	can	can	AUX
admet-737	29	84	even	even	ADV
admet-737	29	85	play	play	VERB
admet-737	29	86	part	part	NOUN
admet-737	29	87	in	in	ADP
admet-737	29	88	post	post	ADJ
admet-737	29	89	-	-	ADJ
admet-737	29	90	market	market	ADJ
admet-737	29	91	surveillance	surveillance	NOUN
admet-737	30	1	[	[	X
admet-737	30	2	21,22	21,22	X
admet-737	30	3	]	]	X
admet-737	30	4	.	.	PUNCT
admet-737	31	1	it	it	PRON
admet-737	31	2	appears	appear	VERB
admet-737	31	3	that	that	SCONJ
admet-737	31	4	the	the	DET
admet-737	31	5	above	above	ADJ
admet-737	31	6	applications	application	NOUN
admet-737	31	7	may	may	AUX
admet-737	31	8	not	not	PART
admet-737	31	9	be	be	AUX
admet-737	31	10	generally	generally	ADV
admet-737	31	11	implemented	implement	VERB
admet-737	31	12	as	as	ADP
admet-737	31	13	an	an	DET
admet-737	31	14	integral	integral	ADJ
admet-737	31	15	part	part	NOUN
admet-737	31	16	of	of	ADP
admet-737	31	17	research	research	NOUN
admet-737	31	18	programs	program	NOUN
admet-737	31	19	in	in	ADP
admet-737	31	20	pharmaceutical	pharmaceutical	ADJ
admet-737	31	21	industry	industry	NOUN
admet-737	32	1	[	[	X
admet-737	32	2	10	10	NUM
admet-737	32	3	]	]	PUNCT
admet-737	32	4	.	.	PUNCT
admet-737	33	1	therefore	therefore	ADV
admet-737	33	2	,	,	PUNCT
admet-737	33	3	the	the	DET
admet-737	33	4	information	information	NOUN
admet-737	33	5	that	that	PRON
admet-737	33	6	can	can	AUX
admet-737	33	7	be	be	AUX
admet-737	33	8	readily	readily	ADV
admet-737	33	9	obtained	obtain	VERB
admet-737	33	10	by	by	ADP
admet-737	33	11	nmr	nmr	NOUN
admet-737	33	12	should	should	AUX
admet-737	33	13	be	be	AUX
admet-737	33	14	further	far	ADV
admet-737	33	15	integrated	integrate	VERB
admet-737	33	16	in	in	ADP
admet-737	33	17	the	the	DET
admet-737	33	18	drug	drug	NOUN
admet-737	33	19	discovery	discovery	NOUN
admet-737	33	20	process	process	NOUN
admet-737	33	21	and	and	CCONJ
admet-737	33	22	wider	wide	ADJ
admet-737	33	23	utilized	utilize	VERB
admet-737	33	24	for	for	ADP
admet-737	33	25	the	the	DET
admet-737	33	26	evaluation	evaluation	NOUN
admet-737	33	27	of	of	ADP
admet-737	33	28	the	the	DET
admet-737	33	29	physico	physico	NOUN
admet-737	33	30	-	-	PUNCT
admet-737	33	31	chemical	chemical	NOUN
admet-737	33	32	properties	property	NOUN
admet-737	33	33	.	.	PUNCT
admet-737	34	1	herein	herein	NOUN
admet-737	34	2	,	,	PUNCT
admet-737	34	3	simpler	simple	ADJ
admet-737	34	4	applications	application	NOUN
admet-737	34	5	of	of	ADP
admet-737	34	6	hydrogen	hydrogen	NOUN
admet-737	34	7	nuclear	nuclear	PROPN
admet-737	34	8	magnetic	magnetic	ADJ
admet-737	34	9	spectroscopy	spectroscopy	NOUN
admet-737	34	10	(	(	PUNCT
admet-737	34	11	1h	1h	NUM
admet-737	34	12	nmr	nmr	NOUN
admet-737	34	13	)	)	PUNCT
admet-737	34	14	spectroscopy	spectroscopy	NOUN
admet-737	34	15	,	,	PUNCT
admet-737	34	16	not	not	PART
admet-737	34	17	often	often	ADV
admet-737	34	18	reported	report	VERB
admet-737	34	19	as	as	ADP
admet-737	34	20	a	a	DET
admet-737	34	21	tool	tool	NOUN
admet-737	34	22	for	for	ADP
admet-737	34	23	evaluating	evaluate	VERB
admet-737	34	24	some	some	DET
admet-737	34	25	admet	admet	NOUN
admet-737	34	26	properties	property	NOUN
admet-737	34	27	,	,	PUNCT
admet-737	34	28	are	be	AUX
admet-737	34	29	explored	explore	VERB
admet-737	34	30	.	.	PUNCT
admet-737	35	1	nmr	nmr	NOUN
admet-737	35	2	quantitative	quantitative	ADJ
admet-737	35	3	nmr	nmr	NOUN
admet-737	35	4	(	(	PUNCT
admet-737	35	5	qnmr	qnmr	PROPN
admet-737	35	6	)	)	PUNCT
admet-737	35	7	most	most	ADJ
admet-737	35	8	of	of	ADP
admet-737	35	9	the	the	DET
admet-737	35	10	adme	adme	NOUN
admet-737	35	11	properties	property	NOUN
admet-737	35	12	rely	rely	VERB
admet-737	35	13	on	on	ADP
admet-737	35	14	concentration	concentration	NOUN
admet-737	35	15	measurements	measurement	NOUN
admet-737	35	16	,	,	PUNCT
admet-737	35	17	where	where	SCONJ
admet-737	35	18	quantitative	quantitative	ADJ
admet-737	35	19	nmr	nmr	NOUN
admet-737	35	20	(	(	PUNCT
admet-737	35	21	qnmr	qnmr	PROPN
admet-737	35	22	)	)	PUNCT
admet-737	35	23	can	can	AUX
admet-737	35	24	play	play	VERB
admet-737	35	25	a	a	DET
admet-737	35	26	significant	significant	ADJ
admet-737	35	27	role	role	NOUN
admet-737	35	28	in	in	ADP
admet-737	35	29	the	the	DET
admet-737	35	30	pharmaceutical	pharmaceutical	ADJ
admet-737	35	31	industry	industry	NOUN
admet-737	35	32	.	.	PUNCT
admet-737	36	1	one	one	NUM
admet-737	36	2	of	of	ADP
admet-737	36	3	the	the	DET
admet-737	36	4	major	major	ADJ
admet-737	36	5	advantages	advantage	NOUN
admet-737	36	6	of	of	ADP
admet-737	36	7	the	the	DET
admet-737	36	8	nmr	nmr	NOUN
admet-737	36	9	spectroscopy	spectroscopy	NOUN
admet-737	36	10	is	be	AUX
admet-737	36	11	its	its	PRON
admet-737	36	12	inherent	inherent	ADJ
admet-737	36	13	quantitative	quantitative	ADJ
admet-737	36	14	nature	nature	NOUN
admet-737	36	15	of	of	ADP
admet-737	36	16	the	the	DET
admet-737	36	17	signal	signal	NOUN
admet-737	36	18	,	,	PUNCT
admet-737	36	19	as	as	SCONJ
admet-737	36	20	the	the	DET
admet-737	36	21	measured	measure	VERB
admet-737	36	22	signals	signal	NOUN
admet-737	36	23	can	can	AUX
admet-737	36	24	be	be	AUX
admet-737	36	25	directly	directly	ADV
admet-737	36	26	proportional	proportional	ADJ
admet-737	36	27	to	to	ADP
admet-737	36	28	the	the	DET
admet-737	36	29	number	number	NOUN
admet-737	36	30	of	of	ADP
admet-737	36	31	investigated	investigate	VERB
admet-737	36	32	nuclei	nucleus	NOUN
admet-737	36	33	in	in	ADP
admet-737	36	34	the	the	DET
admet-737	36	35	same	same	ADJ
admet-737	36	36	environment	environment	NOUN
admet-737	36	37	.	.	PUNCT
admet-737	37	1	these	these	DET
admet-737	37	2	signals	signal	NOUN
admet-737	37	3	can	can	AUX
admet-737	37	4	be	be	AUX
admet-737	37	5	obtained	obtain	VERB
admet-737	37	6	for	for	ADP
admet-737	37	7	nuclei	nucleus	NOUN
admet-737	37	8	most	most	ADV
admet-737	37	9	relevant	relevant	ADJ
admet-737	37	10	to	to	ADP
admet-737	37	11	pharmaceutical	pharmaceutical	ADJ
admet-737	37	12	industry	industry	NOUN
admet-737	37	13	,	,	PUNCT
admet-737	37	14	such	such	ADJ
admet-737	37	15	as	as	ADP
admet-737	37	16	1h	1h	NUM
admet-737	37	17	,	,	PUNCT
admet-737	37	18	13c	13c	NOUN
admet-737	37	19	,	,	PUNCT
admet-737	37	20	19f	19f	NUM
admet-737	37	21	and	and	CCONJ
admet-737	37	22	31p	31p	NOUN
admet-737	37	23	.	.	PUNCT
admet-737	38	1	although	although	SCONJ
admet-737	38	2	the	the	DET
admet-737	38	3	acquisition	acquisition	NOUN
admet-737	38	4	of	of	ADP
admet-737	38	5	19f	19f	PROPN
admet-737	38	6	and	and	CCONJ
admet-737	38	7	31p	31p	NUM
admet-737	38	8	nmr	nmr	NOUN
admet-737	38	9	signals	signal	NOUN
admet-737	38	10	results	result	VERB
admet-737	38	11	in	in	ADP
admet-737	38	12	high	high	ADJ
admet-737	38	13	specificity	specificity	NOUN
admet-737	38	14	analysis	analysis	NOUN
admet-737	38	15	,	,	PUNCT
admet-737	38	16	the	the	DET
admet-737	38	17	1h	1h	NUM
admet-737	38	18	signal	signal	NOUN
admet-737	38	19	is	be	AUX
admet-737	38	20	most	most	ADV
admet-737	38	21	commonly	commonly	ADV
admet-737	38	22	used	use	VERB
admet-737	38	23	in	in	ADP
admet-737	38	24	qnmr	qnmr	ADJ
admet-737	38	25	mire	mire	NOUN
admet-737	38	26	zloh	zloh	PROPN
admet-737	38	27	admet	admet	PROPN
admet-737	38	28	&	&	CCONJ
admet-737	38	29	dmpk	dmpk	PROPN
admet-737	38	30	7(4	7(4	NUM
admet-737	38	31	)	)	PUNCT
admet-737	38	32	(	(	PUNCT
admet-737	38	33	2019	2019	NUM
admet-737	38	34	)	)	PUNCT
admet-737	38	35	242	242	NUM
admet-737	38	36	-	-	SYM
admet-737	38	37	251	251	NUM
admet-737	38	38	244	244	NUM
admet-737	38	39	spectroscopy	spectroscopy	NOUN
admet-737	38	40	due	due	ADP
admet-737	38	41	to	to	ADP
admet-737	38	42	its	its	PRON
admet-737	38	43	presence	presence	NOUN
admet-737	38	44	in	in	ADP
admet-737	38	45	most	most	ADJ
admet-737	38	46	drugs	drug	NOUN
admet-737	38	47	,	,	PUNCT
admet-737	38	48	short	short	ADJ
admet-737	38	49	relaxation	relaxation	NOUN
admet-737	38	50	times	time	NOUN
admet-737	38	51	and	and	CCONJ
admet-737	38	52	higher	high	ADJ
admet-737	38	53	sensitivity	sensitivity	NOUN
admet-737	38	54	when	when	SCONJ
admet-737	38	55	compared	compare	VERB
admet-737	38	56	to	to	ADP
admet-737	38	57	other	other	ADJ
admet-737	38	58	nuclei	nucleus	NOUN
admet-737	38	59	.	.	PUNCT
admet-737	39	1	the	the	DET
admet-737	39	2	adequate	adequate	ADJ
admet-737	39	3	setup	setup	NOUN
admet-737	39	4	of	of	ADP
admet-737	39	5	the	the	DET
admet-737	39	6	experiment	experiment	NOUN
admet-737	39	7	(	(	PUNCT
admet-737	39	8	pulse	pulse	NOUN
admet-737	39	9	sequence	sequence	NOUN
admet-737	39	10	that	that	PRON
admet-737	39	11	allows	allow	VERB
admet-737	39	12	nuclei	nucleus	NOUN
admet-737	39	13	to	to	PART
admet-737	39	14	fully	fully	ADV
admet-737	39	15	relax	relax	VERB
admet-737	39	16	and	and	CCONJ
admet-737	39	17	to	to	PART
admet-737	39	18	minimize	minimize	VERB
admet-737	39	19	nuclear	nuclear	ADJ
admet-737	39	20	overhauser	overhauser	NOUN
admet-737	39	21	effect	effect	NOUN
admet-737	39	22	)	)	PUNCT
admet-737	39	23	will	will	AUX
admet-737	39	24	result	result	VERB
admet-737	39	25	in	in	ADP
admet-737	39	26	an	an	DET
admet-737	39	27	one	one	NUM
admet-737	39	28	dimensional	dimensional	ADJ
admet-737	39	29	(	(	PUNCT
admet-737	39	30	1d	1d	NUM
admet-737	39	31	)	)	PUNCT
admet-737	39	32	nmr	nmr	NOUN
admet-737	39	33	spectrum	spectrum	VERB
admet-737	39	34	with	with	ADP
admet-737	39	35	areas	area	NOUN
admet-737	39	36	under	under	ADP
admet-737	39	37	peaks	peak	NOUN
admet-737	39	38	proportional	proportional	ADJ
admet-737	39	39	to	to	ADP
admet-737	39	40	concentrations	concentration	NOUN
admet-737	39	41	of	of	ADP
admet-737	39	42	sample	sample	NOUN
admet-737	39	43	components	component	NOUN
admet-737	39	44	.	.	PUNCT
admet-737	40	1	this	this	DET
admet-737	40	2	phenomenon	phenomenon	NOUN
admet-737	40	3	is	be	AUX
admet-737	40	4	observed	observe	VERB
admet-737	40	5	for	for	ADP
admet-737	40	6	all	all	DET
admet-737	40	7	molecules	molecule	NOUN
admet-737	40	8	that	that	PRON
admet-737	40	9	contain	contain	VERB
admet-737	40	10	investigated	investigated	ADJ
admet-737	40	11	nuclei	nucleus	NOUN
admet-737	40	12	,	,	PUNCT
admet-737	40	13	as	as	SCONJ
admet-737	40	14	the	the	DET
admet-737	40	15	nmr	nmr	NOUN
admet-737	40	16	does	do	AUX
admet-737	40	17	not	not	PART
admet-737	40	18	depend	depend	VERB
admet-737	40	19	on	on	ADP
admet-737	40	20	compound	compound	NOUN
admet-737	40	21	-	-	PUNCT
admet-737	40	22	specific	specific	ADJ
admet-737	40	23	properties	property	NOUN
admet-737	40	24	,	,	PUNCT
admet-737	40	25	such	such	ADJ
admet-737	40	26	as	as	ADP
admet-737	40	27	presence	presence	NOUN
admet-737	40	28	of	of	ADP
admet-737	40	29	a	a	DET
admet-737	40	30	chromophore	chromophore	NOUN
admet-737	40	31	,	,	PUNCT
admet-737	40	32	chemical	chemical	NOUN
admet-737	40	33	structure	structure	NOUN
admet-737	40	34	or	or	CCONJ
admet-737	40	35	volatility	volatility	NOUN
admet-737	40	36	.	.	PUNCT
admet-737	41	1	furthermore	furthermore	ADV
admet-737	41	2	,	,	PUNCT
admet-737	41	3	if	if	SCONJ
admet-737	41	4	a	a	DET
admet-737	41	5	sample	sample	NOUN
admet-737	41	6	is	be	AUX
admet-737	41	7	fully	fully	ADV
admet-737	41	8	dissolved	dissolve	VERB
admet-737	41	9	,	,	PUNCT
admet-737	41	10	concentrations	concentration	NOUN
admet-737	41	11	of	of	ADP
admet-737	41	12	all	all	DET
admet-737	41	13	compounds	compound	NOUN
admet-737	41	14	with	with	ADP
admet-737	41	15	nmr	nmr	NOUN
admet-737	41	16	active	active	ADJ
admet-737	41	17	nuclei	nucleus	NOUN
admet-737	41	18	can	can	AUX
admet-737	41	19	be	be	AUX
admet-737	41	20	determined	determine	VERB
admet-737	41	21	using	use	VERB
admet-737	41	22	a	a	DET
admet-737	41	23	single	single	ADJ
admet-737	41	24	standard	standard	NOUN
admet-737	41	25	,	,	PUNCT
admet-737	41	26	without	without	ADP
admet-737	41	27	reliance	reliance	NOUN
admet-737	41	28	on	on	ADP
admet-737	41	29	specific	specific	ADJ
admet-737	41	30	reference	reference	NOUN
admet-737	41	31	standards	standard	NOUN
admet-737	41	32	for	for	ADP
admet-737	41	33	each	each	DET
admet-737	41	34	compound	compound	NOUN
admet-737	42	1	[	[	X
admet-737	42	2	23	23	NUM
admet-737	42	3	]	]	PUNCT
admet-737	42	4	.	.	PUNCT
admet-737	43	1	the	the	DET
admet-737	43	2	qnmr	qnmr	NOUN
admet-737	43	3	can	can	AUX
admet-737	43	4	be	be	AUX
admet-737	43	5	used	use	VERB
admet-737	43	6	as	as	ADP
admet-737	43	7	a	a	DET
admet-737	43	8	relative	relative	ADJ
admet-737	43	9	quantification	quantification	NOUN
admet-737	43	10	method	method	NOUN
admet-737	43	11	by	by	ADP
admet-737	43	12	evaluating	evaluate	VERB
admet-737	43	13	molar	molar	ADJ
admet-737	43	14	ratio	ratio	NOUN
admet-737	43	15	between	between	ADP
admet-737	43	16	two	two	NUM
admet-737	43	17	compounds	compound	NOUN
admet-737	43	18	(	(	PUNCT
admet-737	43	19	analyte	analyte	NOUN
admet-737	43	20	and	and	CCONJ
admet-737	43	21	referent	referent	NOUN
admet-737	43	22	compound	compound	NOUN
admet-737	43	23	)	)	PUNCT
admet-737	43	24	in	in	ADP
admet-737	43	25	a	a	DET
admet-737	43	26	solution	solution	NOUN
admet-737	43	27	(	(	PUNCT
admet-737	43	28	eq	eq	NOUN
admet-737	43	29	.	.	NOUN
admet-737	43	30	1	1	NUM
admet-737	43	31	)	)	PUNCT
admet-737	43	32	,	,	PUNCT
admet-737	43	33	or	or	CCONJ
admet-737	43	34	it	it	PRON
admet-737	43	35	can	can	AUX
admet-737	43	36	be	be	AUX
admet-737	43	37	used	use	VERB
admet-737	43	38	to	to	PART
admet-737	43	39	determine	determine	VERB
admet-737	43	40	absolute	absolute	ADJ
admet-737	43	41	content	content	NOUN
admet-737	43	42	of	of	ADP
admet-737	43	43	the	the	DET
admet-737	43	44	analyte	analyte	NOUN
admet-737	43	45	of	of	ADP
admet-737	43	46	a	a	DET
admet-737	43	47	mixture	mixture	NOUN
admet-737	43	48	if	if	SCONJ
admet-737	43	49	the	the	DET
admet-737	43	50	concentration	concentration	NOUN
admet-737	43	51	of	of	ADP
admet-737	43	52	the	the	DET
admet-737	43	53	referent	referent	NOUN
admet-737	43	54	compound	compound	NOUN
admet-737	43	55	is	be	AUX
admet-737	43	56	known	know	VERB
admet-737	43	57	(	(	PUNCT
admet-737	43	58	eq	eq	NOUN
admet-737	43	59	.	.	PROPN
admet-737	43	60	2	2	NUM
admet-737	43	61	):	):	PUNCT
admet-737	43	62	an	an	DET
admet-737	43	63	refan	refan	NOUN
admet-737	43	64	ref	ref	NOUN
admet-737	43	65	ref	ref	VERB
admet-737	43	66	an	an	DET
admet-737	43	67	i	i	NOUN
admet-737	43	68	nn	nn	PROPN
admet-737	43	69	n	n	ADV
admet-737	43	70	i	i	PRON
admet-737	44	1	n	n	ADV
admet-737	44	2			NUM
admet-737	44	3	(	(	PUNCT
admet-737	44	4	1	1	NUM
admet-737	44	5	)	)	PUNCT
admet-737	44	6	an	an	DET
admet-737	44	7	ref	ref	NOUN
admet-737	44	8	an	an	DET
admet-737	44	9	an	an	DET
admet-737	44	10	ref	ref	NOUN
admet-737	44	11	ref	ref	NOUN
admet-737	44	12	an	an	DET
admet-737	44	13	ref	ref	NOUN
admet-737	45	1	i	i	PRON
admet-737	45	2	n	n	VERB
admet-737	45	3	m	m	VERB
admet-737	45	4	m	m	VERB
admet-737	45	5	m	m	VERB
admet-737	45	6	i	i	PRON
admet-737	45	7	n	n	ADV
admet-737	45	8	m	m	VERB
admet-737	45	9			NOUN
admet-737	45	10	(	(	PUNCT
admet-737	45	11	2	2	NUM
admet-737	45	12	)	)	PUNCT
admet-737	45	13	where	where	SCONJ
admet-737	45	14	n	n	PRON
admet-737	45	15	is	be	AUX
admet-737	45	16	the	the	DET
admet-737	45	17	number	number	NOUN
admet-737	45	18	of	of	ADP
admet-737	45	19	mols	mols	PROPN
admet-737	45	20	,	,	PUNCT
admet-737	45	21	i	i	PRON
admet-737	45	22	is	be	AUX
admet-737	45	23	the	the	DET
admet-737	45	24	area	area	NOUN
admet-737	45	25	under	under	ADP
admet-737	45	26	the	the	DET
admet-737	45	27	peak	peak	NOUN
admet-737	45	28	that	that	PRON
admet-737	45	29	correspond	correspond	VERB
admet-737	45	30	to	to	ADP
admet-737	45	31	a	a	DET
admet-737	45	32	signal	signal	NOUN
admet-737	45	33	,	,	PUNCT
admet-737	46	1	n	n	DET
admet-737	46	2	number	number	NOUN
admet-737	46	3	of	of	ADP
admet-737	46	4	nuclei	nucleus	NOUN
admet-737	46	5	contributing	contribute	VERB
admet-737	46	6	to	to	ADP
admet-737	46	7	the	the	DET
admet-737	46	8	signal	signal	NOUN
admet-737	46	9	,	,	PUNCT
admet-737	46	10	m	m	VERB
admet-737	46	11	is	be	AUX
admet-737	46	12	molar	molar	ADJ
admet-737	46	13	mass	mass	NOUN
admet-737	46	14	and	and	CCONJ
admet-737	46	15	m	m	NOUN
admet-737	46	16	is	be	AUX
admet-737	46	17	the	the	DET
admet-737	46	18	gravimetric	gravimetric	ADJ
admet-737	46	19	mass	mass	NOUN
admet-737	46	20	.	.	PUNCT
admet-737	47	1	the	the	DET
admet-737	47	2	above	above	ADJ
admet-737	47	3	approach	approach	NOUN
admet-737	47	4	does	do	AUX
admet-737	47	5	not	not	PART
admet-737	47	6	require	require	VERB
admet-737	47	7	calibration	calibration	NOUN
admet-737	47	8	curves	curve	NOUN
admet-737	47	9	or	or	CCONJ
admet-737	47	10	isolation	isolation	NOUN
admet-737	47	11	of	of	ADP
admet-737	47	12	compounds	compound	NOUN
admet-737	47	13	.	.	PUNCT
admet-737	48	1	multicomponent	multicomponent	NOUN
admet-737	48	2	mixtures	mixture	NOUN
admet-737	48	3	can	can	AUX
admet-737	48	4	be	be	AUX
admet-737	48	5	subjected	subject	VERB
admet-737	48	6	to	to	PART
admet-737	48	7	direct	direct	VERB
admet-737	48	8	and	and	CCONJ
admet-737	48	9	simultaneous	simultaneous	ADJ
admet-737	48	10	determination	determination	NOUN
admet-737	48	11	of	of	ADP
admet-737	48	12	concentrations	concentration	NOUN
admet-737	48	13	of	of	ADP
admet-737	48	14	several	several	ADJ
admet-737	48	15	molecules	molecule	NOUN
admet-737	48	16	as	as	ADV
admet-737	48	17	long	long	ADV
admet-737	48	18	as	as	SCONJ
admet-737	48	19	it	it	PRON
admet-737	48	20	is	be	AUX
admet-737	48	21	possible	possible	ADJ
admet-737	48	22	to	to	PART
admet-737	48	23	find	find	VERB
admet-737	48	24	a	a	DET
admet-737	48	25	characteristic	characteristic	ADJ
admet-737	48	26	signal	signal	NOUN
admet-737	48	27	for	for	ADP
admet-737	48	28	each	each	DET
admet-737	48	29	analyte	analyte	NOUN
admet-737	48	30	.	.	PUNCT
admet-737	49	1	for	for	ADP
admet-737	49	2	example	example	NOUN
admet-737	49	3	,	,	PUNCT
admet-737	49	4	in	in	ADP
admet-737	49	5	a	a	DET
admet-737	49	6	case	case	NOUN
admet-737	49	7	of	of	ADP
admet-737	49	8	quantification	quantification	NOUN
admet-737	49	9	of	of	ADP
admet-737	49	10	caffeine	caffeine	NOUN
admet-737	49	11	,	,	PUNCT
admet-737	49	12	formic	formic	ADJ
admet-737	49	13	acid	acid	NOUN
admet-737	49	14	,	,	PUNCT
admet-737	49	15	trigonelline	trigonelline	ADJ
admet-737	49	16	and	and	CCONJ
admet-737	49	17	5	5	NUM
admet-737	49	18	-	-	PUNCT
admet-737	49	19	hmf	hmf	NOUN
admet-737	49	20	in	in	ADP
admet-737	49	21	soluble	soluble	ADJ
admet-737	49	22	coffees	coffee	NOUN
admet-737	49	23	,	,	PUNCT
admet-737	49	24	singlet	singlet	ADJ
admet-737	49	25	peaks	peak	NOUN
admet-737	49	26	for	for	ADP
admet-737	49	27	molecule	molecule	NOUN
admet-737	49	28	were	be	AUX
admet-737	49	29	identified	identify	VERB
admet-737	49	30	that	that	PRON
admet-737	49	31	were	be	AUX
admet-737	49	32	not	not	PART
admet-737	49	33	overlapping	overlap	VERB
admet-737	49	34	with	with	ADP
admet-737	49	35	the	the	DET
admet-737	49	36	signals	signal	NOUN
admet-737	49	37	from	from	ADP
admet-737	49	38	the	the	DET
admet-737	49	39	other	other	ADJ
admet-737	49	40	components	component	NOUN
admet-737	49	41	present	present	ADJ
admet-737	49	42	in	in	ADP
admet-737	49	43	the	the	DET
admet-737	49	44	sample	sample	NOUN
admet-737	49	45	.	.	PUNCT
admet-737	50	1	that	that	PRON
admet-737	50	2	allowed	allow	VERB
admet-737	50	3	quick	quick	ADJ
admet-737	50	4	and	and	CCONJ
admet-737	50	5	reliable	reliable	ADJ
admet-737	50	6	measurement	measurement	NOUN
admet-737	50	7	of	of	ADP
admet-737	50	8	their	their	PRON
admet-737	50	9	concentrations	concentration	NOUN
admet-737	50	10	with	with	ADP
admet-737	50	11	the	the	DET
admet-737	50	12	limits	limit	NOUN
admet-737	50	13	of	of	ADP
admet-737	50	14	the	the	DET
admet-737	50	15	detection	detection	NOUN
admet-737	50	16	for	for	ADP
admet-737	50	17	each	each	DET
admet-737	50	18	component	component	NOUN
admet-737	50	19	that	that	PRON
admet-737	50	20	were	be	AUX
admet-737	50	21	between	between	ADP
admet-737	50	22	0.3	0.3	NUM
admet-737	50	23	mg	mg	NOUN
admet-737	50	24	to	to	ADP
admet-737	50	25	1.3	1.3	NUM
admet-737	50	26	mg	mg	NOUN
admet-737	50	27	per	per	ADP
admet-737	50	28	gram	gram	NOUN
admet-737	50	29	of	of	ADP
admet-737	50	30	solid	solid	ADJ
admet-737	50	31	product	product	NOUN
admet-737	50	32	[	[	X
admet-737	50	33	24	24	NUM
admet-737	50	34	]	]	PUNCT
admet-737	50	35	.	.	PUNCT
admet-737	51	1	in	in	ADP
admet-737	51	2	pharmaceutical	pharmaceutical	NOUN
admet-737	51	3	industry	industry	NOUN
admet-737	51	4	setting	setting	NOUN
admet-737	51	5	,	,	PUNCT
admet-737	51	6	impurities	impurity	NOUN
admet-737	51	7	(	(	PUNCT
admet-737	51	8	including	include	VERB
admet-737	51	9	toxic	toxic	ADJ
admet-737	51	10	compounds	compound	NOUN
admet-737	51	11	)	)	PUNCT
admet-737	52	1	[	[	X
admet-737	52	2	25	25	NUM
admet-737	52	3	]	]	PUNCT
admet-737	52	4	or	or	CCONJ
admet-737	52	5	components	component	NOUN
admet-737	52	6	of	of	ADP
admet-737	52	7	formulations	formulation	NOUN
admet-737	52	8	can	can	AUX
admet-737	52	9	be	be	AUX
admet-737	52	10	quantified	quantify	VERB
admet-737	52	11	at	at	ADP
admet-737	52	12	the	the	DET
admet-737	52	13	same	same	ADJ
admet-737	52	14	time	time	NOUN
admet-737	52	15	with	with	ADP
admet-737	52	16	measurement	measurement	NOUN
admet-737	52	17	of	of	ADP
admet-737	52	18	the	the	DET
admet-737	52	19	concentration	concentration	NOUN
admet-737	52	20	of	of	ADP
admet-737	52	21	the	the	DET
admet-737	52	22	active	active	ADJ
admet-737	52	23	pharmaceutical	pharmaceutical	ADJ
admet-737	52	24	ingredient	ingredient	NOUN
admet-737	52	25	.	.	PUNCT
admet-737	53	1	the	the	DET
admet-737	53	2	quantification	quantification	NOUN
admet-737	53	3	of	of	ADP
admet-737	53	4	memantine	memantine	ADJ
admet-737	53	5	hydrochloride	hydrochloride	NOUN
admet-737	53	6	from	from	ADP
admet-737	53	7	tablets	tablet	NOUN
admet-737	53	8	dissolved	dissolve	VERB
admet-737	53	9	in	in	ADP
admet-737	53	10	d2o	d2o	NOUN
admet-737	53	11	shown	show	VERB
admet-737	53	12	a	a	DET
admet-737	53	13	good	good	ADJ
admet-737	53	14	separation	separation	NOUN
admet-737	53	15	between	between	ADP
admet-737	53	16	a	a	DET
admet-737	53	17	selected	select	VERB
admet-737	53	18	signal	signal	NOUN
admet-737	53	19	from	from	ADP
admet-737	53	20	signal	signal	NOUN
admet-737	53	21	(	(	PUNCT
admet-737	53	22	three	three	NUM
admet-737	53	23	hydrogens	hydrogen	NOUN
admet-737	53	24	giving	give	VERB
admet-737	53	25	a	a	DET
admet-737	53	26	singlet	singlet	NOUN
admet-737	53	27	at	at	ADP
admet-737	53	28	0.75	0.75	NUM
admet-737	53	29	ppm	ppm	NOUN
admet-737	53	30	)	)	PUNCT
admet-737	53	31	and	and	CCONJ
admet-737	53	32	caffeine	caffeine	NOUN
admet-737	53	33	signal	signal	NOUN
admet-737	53	34	used	use	VERB
admet-737	53	35	as	as	ADP
admet-737	53	36	a	a	DET
admet-737	53	37	referent	referent	NOUN
admet-737	53	38	standard	standard	NOUN
admet-737	53	39	(	(	PUNCT
admet-737	53	40	three	three	NUM
admet-737	53	41	hydrogens	hydrogen	NOUN
admet-737	53	42	giving	give	VERB
admet-737	53	43	a	a	DET
admet-737	53	44	singlet	singlet	NOUN
admet-737	53	45	at	at	ADP
admet-737	53	46	3.13	3.13	NUM
admet-737	53	47	ppm	ppm	NOUN
admet-737	53	48	)	)	PUNCT
admet-737	53	49	(	(	PUNCT
admet-737	53	50	figure	figure	NOUN
admet-737	53	51	1	1	NUM
admet-737	53	52	)	)	PUNCT
admet-737	53	53	.	.	PUNCT
admet-737	54	1	the	the	DET
admet-737	54	2	method	method	NOUN
admet-737	54	3	was	be	AUX
admet-737	54	4	validated	validate	VERB
admet-737	54	5	according	accord	VERB
admet-737	54	6	to	to	ADP
admet-737	54	7	ich	ich	PROPN
admet-737	54	8	guideline	guideline	NOUN
admet-737	54	9	q2	q2	PROPN
admet-737	54	10	(	(	PUNCT
admet-737	54	11	r1	r1	PROPN
admet-737	54	12	)	)	PUNCT
admet-737	54	13	with	with	ADP
admet-737	54	14	demonstrated	demonstrate	VERB
admet-737	54	15	recovery	recovery	NOUN
admet-737	54	16	of	of	ADP
admet-737	54	17	99.26	99.26	NUM
admet-737	54	18	%	%	NOUN
admet-737	54	19	and	and	CCONJ
admet-737	54	20	rsd	rsd	NOUN
admet-737	54	21	of	of	ADP
admet-737	54	22	0.38	0.38	NUM
admet-737	54	23	%	%	NOUN
admet-737	55	1	[	[	X
admet-737	55	2	25	25	NUM
admet-737	55	3	]	]	PUNCT
admet-737	55	4	.	.	PUNCT
admet-737	56	1	the	the	DET
admet-737	56	2	advantages	advantage	NOUN
admet-737	56	3	resulted	result	VERB
admet-737	56	4	in	in	ADP
admet-737	56	5	the	the	PRON
admet-737	56	6	of	of	ADP
admet-737	56	7	use	use	NOUN
admet-737	56	8	of	of	ADP
admet-737	56	9	qnmr	qnmr	NOUN
admet-737	56	10	not	not	PART
admet-737	56	11	only	only	ADV
admet-737	56	12	in	in	ADP
admet-737	56	13	analyses	analysis	NOUN
admet-737	56	14	of	of	ADP
admet-737	56	15	samples	sample	NOUN
admet-737	56	16	of	of	ADP
admet-737	56	17	simple	simple	ADJ
admet-737	56	18	mixtures	mixture	NOUN
admet-737	56	19	of	of	ADP
admet-737	56	20	small	small	ADJ
admet-737	56	21	organic	organic	ADJ
admet-737	56	22	molecules	molecule	NOUN
admet-737	56	23	,	,	PUNCT
admet-737	56	24	but	but	CCONJ
admet-737	56	25	also	also	ADV
admet-737	56	26	in	in	ADP
admet-737	56	27	the	the	DET
admet-737	56	28	evaluation	evaluation	NOUN
admet-737	56	29	of	of	ADP
admet-737	56	30	complex	complex	ADJ
admet-737	56	31	mixtures	mixture	NOUN
admet-737	56	32	found	find	VERB
admet-737	56	33	in	in	ADP
admet-737	56	34	the	the	DET
admet-737	56	35	field	field	NOUN
admet-737	56	36	of	of	ADP
admet-737	56	37	metabolomics	metabolomic	NOUN
admet-737	56	38	and	and	CCONJ
admet-737	56	39	studies	study	NOUN
admet-737	56	40	of	of	ADP
admet-737	56	41	physiological	physiological	ADJ
admet-737	56	42	pathways	pathway	NOUN
admet-737	56	43	.	.	PUNCT
admet-737	57	1	presence	presence	NOUN
admet-737	57	2	of	of	ADP
admet-737	57	3	many	many	ADJ
admet-737	57	4	compounds	compound	NOUN
admet-737	57	5	in	in	ADP
admet-737	57	6	such	such	ADJ
admet-737	57	7	mixtures	mixture	NOUN
admet-737	57	8	results	result	NOUN
admet-737	57	9	in	in	ADP
admet-737	57	10	a	a	DET
admet-737	57	11	difficulty	difficulty	NOUN
admet-737	57	12	to	to	PART
admet-737	57	13	identify	identify	VERB
admet-737	57	14	an	an	DET
admet-737	57	15	isolated	isolated	ADJ
admet-737	57	16	signal	signal	NOUN
admet-737	57	17	of	of	ADP
admet-737	57	18	the	the	DET
admet-737	57	19	referent	referent	NOUN
admet-737	57	20	compound	compound	NOUN
admet-737	57	21	to	to	PART
admet-737	57	22	ensure	ensure	VERB
admet-737	57	23	reliable	reliable	ADJ
admet-737	57	24	quantification	quantification	NOUN
admet-737	57	25	.	.	PUNCT
admet-737	58	1	to	to	PART
admet-737	58	2	facilitate	facilitate	VERB
admet-737	58	3	the	the	DET
admet-737	58	4	optimal	optimal	ADJ
admet-737	58	5	choice	choice	NOUN
admet-737	58	6	of	of	ADP
admet-737	58	7	referent	referent	NOUN
admet-737	58	8	compounds	compound	NOUN
admet-737	58	9	for	for	ADP
admet-737	58	10	a	a	DET
admet-737	58	11	range	range	NOUN
admet-737	58	12	of	of	ADP
admet-737	58	13	samples	sample	NOUN
admet-737	58	14	,	,	PUNCT
admet-737	58	15	a	a	DET
admet-737	58	16	set	set	NOUN
admet-737	58	17	of	of	ADP
admet-737	58	18	15	15	NUM
admet-737	58	19	molecules	molecule	NOUN
admet-737	58	20	were	be	AUX
admet-737	58	21	tested	test	VERB
admet-737	58	22	for	for	ADP
admet-737	58	23	their	their	PRON
admet-737	58	24	properties	property	NOUN
admet-737	58	25	and	and	CCONJ
admet-737	58	26	suitability	suitability	NOUN
admet-737	58	27	for	for	ADP
admet-737	58	28	the	the	DET
admet-737	58	29	use	use	NOUN
admet-737	58	30	in	in	ADP
admet-737	58	31	qnmr	qnmr	NOUN
admet-737	58	32	[	[	X
admet-737	58	33	26	26	NUM
admet-737	58	34	]	]	PUNCT
admet-737	58	35	.	.	PUNCT
admet-737	59	1	in	in	ADP
admet-737	59	2	cases	case	NOUN
admet-737	59	3	where	where	SCONJ
admet-737	59	4	the	the	DET
admet-737	59	5	addition	addition	NOUN
admet-737	59	6	of	of	ADP
admet-737	59	7	an	an	DET
admet-737	59	8	additional	additional	ADJ
admet-737	59	9	components	component	NOUN
admet-737	59	10	can	can	AUX
admet-737	59	11	affect	affect	VERB
admet-737	59	12	the	the	DET
admet-737	59	13	sample	sample	NOUN
admet-737	59	14	,	,	PUNCT
admet-737	59	15	the	the	DET
admet-737	59	16	referent	referent	NOUN
admet-737	59	17	compound	compound	NOUN
admet-737	59	18	can	can	AUX
admet-737	59	19	be	be	AUX
admet-737	59	20	positioned	position	VERB
admet-737	59	21	externally	externally	ADV
admet-737	59	22	or	or	CCONJ
admet-737	59	23	an	an	DET
admet-737	59	24	artificial	artificial	ADJ
admet-737	59	25	referent	referent	NOUN
admet-737	59	26	signal	signal	NOUN
admet-737	59	27	can	can	AUX
admet-737	59	28	be	be	AUX
admet-737	59	29	generated	generate	VERB
admet-737	59	30	by	by	ADP
admet-737	59	31	an	an	DET
admet-737	59	32	nmr	nmr	NOUN
admet-737	59	33	instrument	instrument	NOUN
admet-737	59	34	such	such	ADJ
admet-737	59	35	as	as	ADP
admet-737	59	36	eretic	eretic	ADJ
admet-737	59	37	(	(	PUNCT
admet-737	59	38	electronic	electronic	ADJ
admet-737	59	39	referencing	referencing	NOUN
admet-737	59	40	to	to	ADP
admet-737	59	41	access	access	NOUN
admet-737	59	42	in	in	ADP
admet-737	59	43	vivo	vivo	ADJ
admet-737	59	44	concentrations	concentration	NOUN
admet-737	59	45	)	)	PUNCT
admet-737	59	46	,	,	PUNCT
admet-737	59	47	pig	pig	NOUN
admet-737	59	48	(	(	PUNCT
admet-737	59	49	pulse	pulse	NOUN
admet-737	59	50	into	into	ADP
admet-737	59	51	gradient	gradient	NOUN
admet-737	59	52	)	)	PUNCT
admet-737	59	53	,	,	PUNCT
admet-737	59	54	artsi	artsi	PROPN
admet-737	59	55	(	(	PUNCT
admet-737	59	56	amplitude‐corrected	amplitude‐correcte	VERB
admet-737	59	57	referencing	reference	VERB
admet-737	59	58	through	through	ADP
admet-737	59	59	signal	signal	ADJ
admet-737	59	60	injection	injection	NOUN
admet-737	59	61	)	)	PUNCT
admet-737	59	62	,	,	PUNCT
admet-737	59	63	pulcon	pulcon	NOUN
admet-737	59	64	(	(	PUNCT
admet-737	59	65	pulse	pulse	NOUN
admet-737	59	66	length‐based	length‐based	ADJ
admet-737	59	67	concentration	concentration	NOUN
admet-737	59	68	measurements	measurement	NOUN
admet-737	59	69	)	)	PUNCT
admet-737	59	70	and	and	CCONJ
admet-737	59	71	quantas	quanta	NOUN
admet-737	59	72	(	(	PUNCT
admet-737	59	73	quantification	quantification	NOUN
admet-737	59	74	by	by	ADP
admet-737	59	75	artificial	artificial	ADJ
admet-737	59	76	signal	signal	NOUN
admet-737	59	77	)	)	PUNCT
admet-737	60	1	[	[	X
admet-737	60	2	27	27	NUM
admet-737	60	3	]	]	PUNCT
admet-737	60	4	.	.	PUNCT
admet-737	61	1	admet	admet	PROPN
admet-737	61	2	&	&	CCONJ
admet-737	61	3	dmpk	dmpk	PROPN
admet-737	61	4	7(4	7(4	NUM
admet-737	61	5	)	)	PUNCT
admet-737	61	6	(	(	PUNCT
admet-737	61	7	2019	2019	NUM
admet-737	61	8	)	)	PUNCT
admet-737	61	9	242	242	NUM
admet-737	61	10	-	-	SYM
admet-737	61	11	251	251	NUM
admet-737	61	12	nmr	nmr	NOUN
admet-737	61	13	spectroscopy	spectroscopy	NOUN
admet-737	61	14	in	in	ADP
admet-737	61	15	drug	drug	NOUN
admet-737	61	16	discovery	discovery	NOUN
admet-737	61	17	and	and	CCONJ
admet-737	61	18	development	development	NOUN
admet-737	61	19	doi	doi	PROPN
admet-737	61	20	:	:	PUNCT
admet-737	61	21	10.5599	10.5599	NUM
admet-737	61	22	/	/	SYM
admet-737	61	23	admet.737	admet.737	PROPN
admet-737	61	24	245	245	NUM
admet-737	61	25	the	the	DET
admet-737	61	26	reliability	reliability	NOUN
admet-737	61	27	and	and	CCONJ
admet-737	61	28	accuracy	accuracy	NOUN
admet-737	61	29	of	of	ADP
admet-737	61	30	concentration	concentration	NOUN
admet-737	61	31	determination	determination	NOUN
admet-737	61	32	using	use	VERB
admet-737	61	33	qnmr	qnmr	NOUN
admet-737	61	34	depend	depend	VERB
admet-737	61	35	on	on	ADP
admet-737	61	36	the	the	DET
admet-737	61	37	experiment	experiment	NOUN
admet-737	61	38	parameters	parameter	NOUN
admet-737	61	39	setup	setup	NOUN
admet-737	61	40	and	and	CCONJ
admet-737	61	41	consideration	consideration	NOUN
admet-737	61	42	of	of	ADP
admet-737	61	43	sample	sample	NOUN
admet-737	61	44	conditions	condition	NOUN
admet-737	61	45	,	,	PUNCT
admet-737	61	46	which	which	PRON
admet-737	61	47	is	be	AUX
admet-737	61	48	extensively	extensively	ADV
admet-737	61	49	covered	cover	VERB
admet-737	61	50	elsewhere	elsewhere	ADV
admet-737	61	51	[	[	X
admet-737	61	52	28,29	28,29	X
admet-737	61	53	]	]	PUNCT
admet-737	61	54	.	.	PUNCT
admet-737	62	1	in	in	ADP
admet-737	62	2	reality	reality	NOUN
admet-737	62	3	,	,	PUNCT
admet-737	62	4	the	the	DET
admet-737	62	5	experimental	experimental	ADJ
admet-737	62	6	setup	setup	NOUN
admet-737	62	7	can	can	AUX
admet-737	62	8	be	be	AUX
admet-737	62	9	optimized	optimize	VERB
admet-737	62	10	to	to	PART
admet-737	62	11	reduce	reduce	VERB
admet-737	62	12	the	the	DET
admet-737	62	13	quantitative	quantitative	ADJ
admet-737	62	14	inaccuracy	inaccuracy	NOUN
admet-737	62	15	of	of	ADP
admet-737	62	16	qnmr	qnmr	NOUN
admet-737	62	17	below	below	ADP
admet-737	62	18	2.0	2.0	NUM
admet-737	62	19	%	%	NOUN
admet-737	62	20	,	,	PUNCT
admet-737	62	21	an	an	DET
admet-737	62	22	acceptable	acceptable	ADJ
admet-737	62	23	limit	limit	NOUN
admet-737	62	24	for	for	ADP
admet-737	62	25	precise	precise	ADJ
admet-737	62	26	and	and	CCONJ
admet-737	62	27	accurate	accurate	ADJ
admet-737	62	28	quantification[30	quantification[30	NOUN
admet-737	62	29	]	]	PUNCT
admet-737	62	30	.	.	PUNCT
admet-737	63	1	furthermore	furthermore	ADV
admet-737	63	2	,	,	PUNCT
admet-737	63	3	the	the	DET
admet-737	63	4	nmr	nmr	NOUN
admet-737	63	5	concentration	concentration	NOUN
admet-737	63	6	determination	determination	NOUN
admet-737	63	7	can	can	AUX
admet-737	63	8	be	be	AUX
admet-737	63	9	achieved	achieve	VERB
admet-737	63	10	from	from	ADP
admet-737	63	11	low	low	ADJ
admet-737	63	12	micromolar	micromolar	ADJ
admet-737	63	13	concentrations	concentration	NOUN
admet-737	63	14	4	4	NUM
admet-737	63	15	μm	μm	NOUN
admet-737	63	16	even	even	ADV
admet-737	63	17	if	if	SCONJ
admet-737	63	18	the	the	DET
admet-737	63	19	solvent	solvent	ADJ
admet-737	63	20	water	water	NOUN
admet-737	63	21	peak	peak	NOUN
admet-737	63	22	is	be	AUX
admet-737	63	23	used	use	VERB
admet-737	63	24	as	as	ADP
admet-737	63	25	the	the	DET
admet-737	63	26	concentration	concentration	NOUN
admet-737	63	27	reference	reference	NOUN
admet-737	63	28	[	[	X
admet-737	63	29	31	31	NUM
admet-737	63	30	]	]	PUNCT
admet-737	63	31	.	.	PUNCT
admet-737	64	1	this	this	DET
admet-737	64	2	approach	approach	NOUN
admet-737	64	3	expands	expand	VERB
admet-737	64	4	the	the	DET
admet-737	64	5	applicability	applicability	NOUN
admet-737	64	6	domain	domain	NOUN
admet-737	64	7	of	of	ADP
admet-737	64	8	the	the	DET
admet-737	64	9	qnmr	qnmr	NOUN
admet-737	64	10	as	as	SCONJ
admet-737	64	11	the	the	DET
admet-737	64	12	effects	effect	NOUN
admet-737	64	13	of	of	ADP
admet-737	64	14	deuterated	deuterate	VERB
admet-737	64	15	water	water	NOUN
admet-737	64	16	on	on	ADP
admet-737	64	17	pka	pka	PROPN
admet-737	64	18	,	,	PUNCT
admet-737	64	19	log	log	VERB
admet-737	64	20	p	p	NOUN
admet-737	64	21	and	and	CCONJ
admet-737	64	22	other	other	ADJ
admet-737	64	23	physico	physico	NOUN
admet-737	64	24	-	-	PUNCT
admet-737	64	25	chemical	chemical	NOUN
admet-737	64	26	parameters	parameter	NOUN
admet-737	64	27	are	be	AUX
admet-737	64	28	removed	remove	VERB
admet-737	64	29	.	.	PUNCT
admet-737	65	1	figure	figure	NOUN
admet-737	65	2	1	1	NUM
admet-737	65	3	.	.	PUNCT
admet-737	66	1	overlay	overlay	NOUN
admet-737	66	2	of	of	ADP
admet-737	66	3	1	1	NUM
admet-737	66	4	h	h	NOUN
admet-737	66	5	nmr	nmr	NOUN
admet-737	66	6	spectra	spectra	NOUN
admet-737	66	7	of	of	ADP
admet-737	66	8	memantine	memantine	ADJ
admet-737	66	9	hydrochloride	hydrochloride	NOUN
admet-737	66	10	from	from	ADP
admet-737	66	11	tablets	tablet	NOUN
admet-737	66	12	in	in	ADP
admet-737	66	13	solution	solution	NOUN
admet-737	66	14	(	(	PUNCT
admet-737	66	15	a	a	X
admet-737	66	16	)	)	PUNCT
admet-737	66	17	,	,	PUNCT
admet-737	66	18	drug	drug	NOUN
admet-737	66	19	standard	standard	NOUN
admet-737	66	20	(	(	PUNCT
admet-737	66	21	b	b	NOUN
admet-737	66	22	)	)	PUNCT
admet-737	66	23	,	,	PUNCT
admet-737	66	24	internal	internal	ADJ
admet-737	66	25	standard	standard	NOUN
admet-737	66	26	(	(	PUNCT
admet-737	66	27	c	c	NOUN
admet-737	66	28	)	)	PUNCT
admet-737	66	29	,	,	PUNCT
admet-737	66	30	and	and	CCONJ
admet-737	66	31	blank	blank	ADJ
admet-737	66	32	(	(	PUNCT
admet-737	66	33	d	d	NOUN
admet-737	66	34	)	)	PUNCT
admet-737	66	35	.	.	PUNCT
admet-737	67	1	all	all	DET
admet-737	67	2	spectra	spectra	PROPN
admet-737	67	3	were	be	AUX
admet-737	67	4	acquired	acquire	VERB
admet-737	67	5	with	with	ADP
admet-737	67	6	same	same	ADJ
admet-737	67	7	parameters	parameter	NOUN
admet-737	67	8	and	and	CCONJ
admet-737	67	9	processed	process	VERB
admet-737	67	10	similarly	similarly	ADV
admet-737	67	11	.	.	PUNCT
admet-737	68	1	taken	take	VERB
admet-737	68	2	with	with	ADP
admet-737	68	3	permission	permission	NOUN
admet-737	68	4	from	from	ADP
admet-737	68	5	[	[	X
admet-737	68	6	25	25	NUM
admet-737	68	7	]	]	PUNCT
admet-737	68	8	.	.	PUNCT
admet-737	69	1	copyright	copyright	NOUN
admet-737	69	2	(	(	PUNCT
admet-737	69	3	2016	2016	NUM
admet-737	69	4	)	)	PUNCT
admet-737	69	5	with	with	ADP
admet-737	69	6	permission	permission	NOUN
admet-737	69	7	from	from	ADP
admet-737	69	8	wiley	wiley	PROPN
admet-737	69	9	.	.	PUNCT
admet-737	69	10	drug	drug	NOUN
admet-737	69	11	solubility	solubility	NOUN
admet-737	69	12	drug	drug	NOUN
admet-737	69	13	solubility	solubility	NOUN
admet-737	69	14	is	be	AUX
admet-737	69	15	one	one	NUM
admet-737	69	16	of	of	ADP
admet-737	69	17	the	the	DET
admet-737	69	18	key	key	ADJ
admet-737	69	19	properties	property	NOUN
admet-737	69	20	that	that	PRON
admet-737	69	21	influences	influence	VERB
admet-737	69	22	the	the	DET
admet-737	69	23	permeability	permeability	NOUN
admet-737	69	24	and	and	CCONJ
admet-737	69	25	concentration	concentration	NOUN
admet-737	69	26	of	of	ADP
admet-737	69	27	the	the	DET
admet-737	69	28	active	active	ADJ
admet-737	69	29	pharmaceutical	pharmaceutical	ADJ
admet-737	69	30	ingredient	ingredient	NOUN
admet-737	69	31	in	in	ADP
admet-737	69	32	the	the	DET
admet-737	69	33	physiological	physiological	ADJ
admet-737	69	34	conditions	condition	NOUN
admet-737	69	35	after	after	ADP
admet-737	69	36	administration	administration	NOUN
admet-737	69	37	.	.	PUNCT
admet-737	70	1	while	while	SCONJ
admet-737	70	2	the	the	DET
admet-737	70	3	hplc	hplc	NOUN
admet-737	70	4	measurements	measurement	NOUN
admet-737	70	5	are	be	AUX
admet-737	70	6	generally	generally	ADV
admet-737	70	7	used	use	VERB
admet-737	70	8	to	to	PART
admet-737	70	9	determine	determine	VERB
admet-737	70	10	solubility	solubility	NOUN
admet-737	70	11	of	of	ADP
admet-737	70	12	drugs	drug	NOUN
admet-737	70	13	,	,	PUNCT
admet-737	70	14	as	as	ADP
admet-737	70	15	one	one	NUM
admet-737	70	16	of	of	ADP
admet-737	70	17	the	the	DET
admet-737	70	18	most	most	ADV
admet-737	70	19	reliable	reliable	ADJ
admet-737	70	20	and	and	CCONJ
admet-737	70	21	sensitive	sensitive	ADJ
admet-737	70	22	methods	method	NOUN
admet-737	70	23	,	,	PUNCT
admet-737	70	24	it	it	PRON
admet-737	70	25	may	may	AUX
admet-737	70	26	be	be	AUX
admet-737	70	27	relatively	relatively	ADV
admet-737	70	28	slow	slow	ADJ
admet-737	70	29	process	process	NOUN
admet-737	70	30	as	as	ADV
admet-737	70	31	often	often	ADV
admet-737	70	32	requires	require	VERB
admet-737	70	33	method	method	NOUN
admet-737	70	34	development	development	NOUN
admet-737	70	35	and	and	CCONJ
admet-737	70	36	creation	creation	NOUN
admet-737	70	37	of	of	ADP
admet-737	70	38	a	a	DET
admet-737	70	39	calibration	calibration	NOUN
admet-737	70	40	curve	curve	NOUN
admet-737	70	41	for	for	ADP
admet-737	70	42	quantitation	quantitation	NOUN
admet-737	70	43	.	.	PUNCT
admet-737	71	1	the	the	DET
admet-737	71	2	need	need	NOUN
admet-737	71	3	for	for	ADP
admet-737	71	4	faster	fast	ADJ
admet-737	71	5	measurements	measurement	NOUN
admet-737	71	6	of	of	ADP
admet-737	71	7	large	large	ADJ
admet-737	71	8	number	number	NOUN
admet-737	71	9	of	of	ADP
admet-737	71	10	compounds	compound	NOUN
admet-737	71	11	,	,	PUNCT
admet-737	71	12	often	often	ADV
admet-737	71	13	with	with	ADP
admet-737	71	14	limited	limited	ADJ
admet-737	71	15	amounts	amount	NOUN
admet-737	71	16	,	,	PUNCT
admet-737	71	17	qnmr	qnmr	NOUN
admet-737	71	18	can	can	AUX
admet-737	71	19	be	be	AUX
admet-737	71	20	used	use	VERB
admet-737	71	21	to	to	PART
admet-737	71	22	develop	develop	VERB
admet-737	71	23	faster	fast	ADJ
admet-737	71	24	methods	method	NOUN
admet-737	71	25	for	for	ADP
admet-737	71	26	solubility	solubility	NOUN
admet-737	71	27	measurement	measurement	NOUN
admet-737	71	28	,	,	PUNCT
admet-737	71	29	even	even	ADV
admet-737	71	30	in	in	ADP
admet-737	71	31	complex	complex	ADJ
admet-737	71	32	matrices	matrix	NOUN
admet-737	71	33	that	that	PRON
admet-737	71	34	may	may	AUX
admet-737	71	35	affect	affect	VERB
admet-737	71	36	drug	drug	NOUN
admet-737	71	37	solubility	solubility	NOUN
admet-737	71	38	.	.	PUNCT
admet-737	72	1	as	as	SCONJ
admet-737	72	2	the	the	DET
admet-737	72	3	nmr	nmr	NOUN
admet-737	72	4	is	be	AUX
admet-737	72	5	fast	fast	ADJ
admet-737	72	6	method	method	NOUN
admet-737	72	7	with	with	ADP
admet-737	72	8	relatively	relatively	ADV
admet-737	72	9	simple	simple	ADJ
admet-737	72	10	sample	sample	NOUN
admet-737	72	11	preparation	preparation	NOUN
admet-737	72	12	procedure	procedure	NOUN
admet-737	72	13	,	,	PUNCT
admet-737	72	14	it	it	PRON
admet-737	72	15	can	can	AUX
admet-737	72	16	be	be	AUX
admet-737	72	17	used	use	VERB
admet-737	72	18	to	to	PART
admet-737	72	19	determine	determine	VERB
admet-737	72	20	drug	drug	NOUN
admet-737	72	21	solubility	solubility	NOUN
admet-737	72	22	in	in	ADP
admet-737	72	23	simple	simple	ADJ
admet-737	72	24	formulations	formulation	NOUN
admet-737	72	25	,	,	PUNCT
admet-737	72	26	by	by	ADP
admet-737	72	27	calculation	calculation	NOUN
admet-737	72	28	the	the	DET
admet-737	72	29	integration	integration	NOUN
admet-737	72	30	ratio	ratio	NOUN
admet-737	72	31	of	of	ADP
admet-737	72	32	the	the	DET
admet-737	72	33	drug	drug	NOUN
admet-737	72	34	signal	signal	NOUN
admet-737	72	35	to	to	ADP
admet-737	72	36	the	the	DET
admet-737	72	37	internal	internal	ADJ
admet-737	72	38	water	water	NOUN
admet-737	72	39	soluble	soluble	ADJ
admet-737	72	40	standard	standard	PROPN
admet-737	72	41	3-(trimethylsilyl)propionic2,2,3,3	3-(trimethylsilyl)propionic2,2,3,3	PROPN
admet-737	72	42	-	-	PUNCT
admet-737	72	43	d4	d4	PROPN
admet-737	72	44	acid	acid	NOUN
admet-737	72	45	,	,	PUNCT
admet-737	72	46	sodium	sodium	NOUN
admet-737	72	47	salt	salt	NOUN
admet-737	72	48	signal	signal	NOUN
admet-737	73	1	[	[	X
admet-737	73	2	32	32	NUM
admet-737	73	3	]	]	PUNCT
admet-737	73	4	.	.	PUNCT
admet-737	74	1	the	the	DET
admet-737	74	2	further	further	ADJ
admet-737	74	3	advantage	advantage	NOUN
admet-737	74	4	is	be	AUX
admet-737	74	5	that	that	SCONJ
admet-737	74	6	the	the	DET
admet-737	74	7	concentrations	concentration	NOUN
admet-737	74	8	of	of	ADP
admet-737	74	9	all	all	DET
admet-737	74	10	hydrogen	hydrogen	NOUN
admet-737	74	11	containing	contain	VERB
admet-737	74	12	components	component	NOUN
admet-737	74	13	of	of	ADP
admet-737	74	14	the	the	DET
admet-737	74	15	formulation	formulation	NOUN
admet-737	74	16	could	could	AUX
admet-737	74	17	be	be	AUX
admet-737	74	18	determined	determine	VERB
admet-737	74	19	simultaneously	simultaneously	ADV
admet-737	74	20	,	,	PUNCT
admet-737	74	21	along	along	ADP
admet-737	74	22	with	with	ADP
admet-737	74	23	detecting	detect	VERB
admet-737	74	24	possible	possible	ADJ
admet-737	74	25	impurities	impurity	NOUN
admet-737	74	26	.	.	PUNCT
admet-737	75	1	the	the	DET
admet-737	75	2	new	new	ADJ
admet-737	75	3	peaks	peak	NOUN
admet-737	75	4	that	that	PRON
admet-737	75	5	appear	appear	VERB
admet-737	75	6	in	in	ADP
admet-737	75	7	samples	sample	NOUN
admet-737	75	8	,	,	PUNCT
admet-737	75	9	possibly	possibly	ADV
admet-737	75	10	during	during	ADP
admet-737	75	11	the	the	DET
admet-737	75	12	degradation	degradation	NOUN
admet-737	75	13	studies	study	NOUN
admet-737	75	14	,	,	PUNCT
admet-737	75	15	can	can	AUX
admet-737	75	16	be	be	AUX
admet-737	75	17	quantified	quantify	VERB
admet-737	75	18	by	by	ADP
admet-737	75	19	nmr	nmr	NOUN
admet-737	75	20	and	and	CCONJ
admet-737	75	21	further	far	ADV
admet-737	75	22	characterized	characterize	VERB
admet-737	75	23	by	by	ADP
admet-737	75	24	a	a	DET
admet-737	75	25	combination	combination	NOUN
admet-737	75	26	of	of	ADP
admet-737	75	27	nmr	nmr	NOUN
admet-737	75	28	spectroscopy	spectroscopy	NOUN
admet-737	75	29	and	and	CCONJ
admet-737	75	30	mass	mass	ADJ
admet-737	75	31	spectrometry	spectrometry	NOUN
admet-737	75	32	(	(	PUNCT
admet-737	75	33	ms	ms	PROPN
admet-737	75	34	)	)	PUNCT
admet-737	75	35	protocol	protocol	NOUN
admet-737	75	36	(	(	PUNCT
admet-737	75	37	figure	figure	NOUN
admet-737	75	38	2	2	NUM
admet-737	75	39	)	)	PUNCT
admet-737	76	1	[	[	X
admet-737	76	2	33	33	NUM
admet-737	76	3	]	]	PUNCT
admet-737	76	4	.	.	PUNCT
admet-737	77	1	additionally	additionally	ADV
admet-737	77	2	,	,	PUNCT
admet-737	77	3	qnmr	qnmr	PROPN
admet-737	77	4	also	also	ADV
admet-737	77	5	allows	allow	VERB
admet-737	77	6	determination	determination	NOUN
admet-737	77	7	of	of	ADP
admet-737	77	8	drug	drug	NOUN
admet-737	77	9	concentrations	concentration	NOUN
admet-737	77	10	in	in	ADP
admet-737	77	11	presence	presence	NOUN
admet-737	77	12	of	of	ADP
admet-737	77	13	excipients	excipient	NOUN
admet-737	77	14	without	without	ADP
admet-737	77	15	separation	separation	NOUN
admet-737	77	16	and	and	CCONJ
admet-737	77	17	at	at	ADP
admet-737	77	18	different	different	ADJ
admet-737	77	19	temperatures	temperature	NOUN
admet-737	77	20	[	[	X
admet-737	77	21	34	34	NUM
admet-737	77	22	]	]	PUNCT
admet-737	77	23	.	.	PUNCT
admet-737	78	1	mire	mire	NOUN
admet-737	78	2	zloh	zloh	PROPN
admet-737	78	3	admet	admet	PROPN
admet-737	78	4	&	&	CCONJ
admet-737	78	5	dmpk	dmpk	PROPN
admet-737	78	6	7(4	7(4	NUM
admet-737	78	7	)	)	PUNCT
admet-737	78	8	(	(	PUNCT
admet-737	78	9	2019	2019	NUM
admet-737	78	10	)	)	PUNCT
admet-737	78	11	242	242	NUM
admet-737	78	12	-	-	SYM
admet-737	78	13	251	251	NUM
admet-737	78	14	246	246	NUM
admet-737	78	15	figure	figure	NOUN
admet-737	78	16	2	2	NUM
admet-737	78	17	.	.	PUNCT
admet-737	78	18	workflow	workflow	NOUN
admet-737	78	19	of	of	ADP
admet-737	78	20	the	the	DET
admet-737	78	21	mass	mass	ADJ
admet-737	78	22	spectrometric	spectrometric	ADJ
admet-737	78	23	-	-	PUNCT
admet-737	78	24	nuclear	nuclear	ADJ
admet-737	78	25	magnetic	magnetic	ADJ
admet-737	78	26	resonance	resonance	NOUN
admet-737	78	27	(	(	PUNCT
admet-737	78	28	ms	ms	NOUN
admet-737	78	29	-	-	PUNCT
admet-737	78	30	nmr	nmr	NOUN
admet-737	78	31	)	)	PUNCT
admet-737	78	32	approach	approach	NOUN
admet-737	78	33	.	.	PUNCT
admet-737	79	1	taken	take	VERB
admet-737	79	2	from	from	ADP
admet-737	79	3	[	[	X
admet-737	79	4	33	33	NUM
admet-737	79	5	]	]	PUNCT
admet-737	79	6	.	.	PUNCT
admet-737	80	1	copyright	copyright	NOUN
admet-737	80	2	(	(	PUNCT
admet-737	80	3	2019	2019	NUM
admet-737	80	4	)	)	PUNCT
admet-737	80	5	from	from	ADP
admet-737	80	6	mdpi	mdpi	PROPN
admet-737	80	7	under	under	ADP
admet-737	80	8	creative	creative	ADJ
admet-737	80	9	commons	common	NOUN
admet-737	80	10	attribution	attribution	NOUN
admet-737	80	11	(	(	PUNCT
admet-737	80	12	cc	cc	NOUN
admet-737	80	13	by	by	ADP
admet-737	80	14	)	)	PUNCT
admet-737	80	15	license	license	NOUN
admet-737	80	16	.	.	PUNCT
admet-737	81	1	often	often	ADV
admet-737	81	2	,	,	PUNCT
admet-737	81	3	quantification	quantification	NOUN
admet-737	81	4	of	of	ADP
admet-737	81	5	the	the	DET
admet-737	81	6	concentration	concentration	NOUN
admet-737	81	7	of	of	ADP
admet-737	81	8	an	an	DET
admet-737	81	9	active	active	ADJ
admet-737	81	10	pharmaceutical	pharmaceutical	ADJ
admet-737	81	11	ingredient	ingredient	NOUN
admet-737	81	12	in	in	ADP
admet-737	81	13	complex	complex	ADJ
admet-737	81	14	mixtures	mixture	NOUN
admet-737	81	15	is	be	AUX
admet-737	81	16	impeded	impede	VERB
admet-737	81	17	in	in	ADP
admet-737	81	18	one	one	NUM
admet-737	81	19	-	-	PUNCT
admet-737	81	20	dimensional	dimensional	ADJ
admet-737	81	21	hydrogen	hydrogen	NOUN
admet-737	81	22	(	(	PUNCT
admet-737	81	23	1d	1d	NUM
admet-737	81	24	1h	1h	NUM
admet-737	81	25	)	)	PUNCT
admet-737	81	26	nmr	nmr	NOUN
admet-737	81	27	spectra	spectra	NOUN
admet-737	81	28	due	due	ADP
admet-737	81	29	to	to	ADP
admet-737	81	30	the	the	DET
admet-737	81	31	signal	signal	ADJ
admet-737	81	32	overlap	overlap	NOUN
admet-737	81	33	.	.	PUNCT
admet-737	82	1	the	the	DET
admet-737	82	2	addition	addition	NOUN
admet-737	82	3	in	in	ADP
admet-737	82	4	signal	signal	ADJ
admet-737	82	5	separation	separation	NOUN
admet-737	82	6	along	along	ADP
admet-737	82	7	the	the	DET
admet-737	82	8	second	second	ADJ
admet-737	82	9	dimension	dimension	NOUN
admet-737	82	10	in	in	ADP
admet-737	82	11	two	two	NUM
admet-737	82	12	-	-	PUNCT
admet-737	82	13	dimensional	dimensional	ADJ
admet-737	82	14	(	(	PUNCT
admet-737	82	15	2d	2d	NOUN
admet-737	82	16	)	)	PUNCT
admet-737	82	17	nmr	nmr	NOUN
admet-737	82	18	spectra	spectra	NOUN
admet-737	82	19	generally	generally	ADV
admet-737	82	20	leads	lead	VERB
admet-737	82	21	to	to	ADP
admet-737	82	22	reduction	reduction	NOUN
admet-737	82	23	of	of	ADP
admet-737	82	24	signal	signal	ADJ
admet-737	82	25	overlap	overlap	NOUN
admet-737	82	26	.	.	PUNCT
admet-737	83	1	the	the	DET
admet-737	83	2	2d	2d	NUM
admet-737	83	3	correlation	correlation	NOUN
admet-737	83	4	spectroscopy	spectroscopy	NOUN
admet-737	83	5	(	(	PUNCT
admet-737	83	6	cosy	cosy	NOUN
admet-737	83	7	)	)	PUNCT
admet-737	83	8	nmr	nmr	NOUN
admet-737	83	9	spectra	spectra	NOUN
admet-737	83	10	can	can	AUX
admet-737	83	11	be	be	AUX
admet-737	83	12	used	use	VERB
admet-737	83	13	for	for	ADP
admet-737	83	14	quantification	quantification	NOUN
admet-737	83	15	purposes	purpose	NOUN
admet-737	83	16	by	by	ADP
admet-737	83	17	integrating	integrate	VERB
admet-737	83	18	the	the	DET
admet-737	83	19	volumes	volume	NOUN
admet-737	83	20	of	of	ADP
admet-737	83	21	crosspeaks	crosspeak	NOUN
admet-737	83	22	of	of	ADP
admet-737	83	23	metabolites	metabolite	NOUN
admet-737	83	24	,	,	PUNCT
admet-737	83	25	that	that	PRON
admet-737	83	26	are	be	AUX
admet-737	83	27	proportional	proportional	ADJ
admet-737	83	28	to	to	ADP
admet-737	83	29	their	their	PRON
admet-737	83	30	concentrations	concentration	NOUN
admet-737	83	31	[	[	X
admet-737	83	32	35	35	NUM
admet-737	83	33	]	]	PUNCT
admet-737	83	34	.	.	PUNCT
admet-737	84	1	there	there	PRON
admet-737	84	2	is	be	VERB
admet-737	84	3	a	a	DET
admet-737	84	4	plethora	plethora	NOUN
admet-737	84	5	of	of	ADP
admet-737	84	6	different	different	ADJ
admet-737	84	7	homoand	homoand	NOUN
admet-737	84	8	heteronuclear	heteronuclear	NOUN
admet-737	84	9	experiments	experiment	NOUN
admet-737	84	10	that	that	PRON
admet-737	84	11	can	can	AUX
admet-737	84	12	be	be	AUX
admet-737	84	13	used	use	VERB
admet-737	84	14	to	to	PART
admet-737	84	15	obtain	obtain	VERB
admet-737	84	16	quantitative	quantitative	ADJ
admet-737	84	17	information	information	NOUN
admet-737	84	18	about	about	ADP
admet-737	84	19	sample	sample	NOUN
admet-737	84	20	components	component	NOUN
admet-737	84	21	.	.	PUNCT
admet-737	85	1	although	although	SCONJ
admet-737	85	2	this	this	DET
admet-737	85	3	relationship	relationship	NOUN
admet-737	85	4	between	between	ADP
admet-737	85	5	the	the	DET
admet-737	85	6	peak	peak	NOUN
admet-737	85	7	volume	volume	NOUN
admet-737	85	8	and	and	CCONJ
admet-737	85	9	the	the	DET
admet-737	85	10	concentration	concentration	NOUN
admet-737	85	11	is	be	AUX
admet-737	85	12	not	not	PART
admet-737	85	13	as	as	ADV
admet-737	85	14	simple	simple	ADJ
admet-737	85	15	as	as	ADP
admet-737	85	16	in	in	ADP
admet-737	85	17	1d	1d	NUM
admet-737	85	18	nmr	nmr	NOUN
admet-737	85	19	spectroscopy	spectroscopy	NOUN
admet-737	85	20	,	,	PUNCT
admet-737	85	21	the	the	DET
admet-737	85	22	volume	volume	NOUN
admet-737	85	23	of	of	ADP
admet-737	85	24	the	the	DET
admet-737	85	25	signal	signal	NOUN
admet-737	85	26	depends	depend	VERB
admet-737	85	27	on	on	ADP
admet-737	85	28	various	various	ADJ
admet-737	85	29	peak	peak	NOUN
admet-737	85	30	relevant	relevant	ADJ
admet-737	85	31	parameters	parameter	NOUN
admet-737	85	32	,	,	PUNCT
admet-737	85	33	including	include	VERB
admet-737	85	34	relaxation	relaxation	NOUN
admet-737	85	35	times	time	NOUN
admet-737	85	36	,	,	PUNCT
admet-737	85	37	coupling	couple	VERB
admet-737	85	38	between	between	ADP
admet-737	85	39	different	different	ADJ
admet-737	85	40	nuclei	nucleus	NOUN
admet-737	85	41	and	and	CCONJ
admet-737	85	42	pulse	pulse	NOUN
admet-737	85	43	sequence	sequence	NOUN
admet-737	85	44	parameters	parameter	NOUN
admet-737	85	45	,	,	PUNCT
admet-737	85	46	there	there	PRON
admet-737	85	47	is	be	VERB
admet-737	85	48	a	a	DET
admet-737	85	49	range	range	NOUN
admet-737	85	50	of	of	ADP
admet-737	85	51	strategies	strategy	NOUN
admet-737	85	52	that	that	PRON
admet-737	85	53	can	can	AUX
admet-737	85	54	be	be	AUX
admet-737	85	55	employed	employ	VERB
admet-737	85	56	to	to	PART
admet-737	85	57	achieve	achieve	VERB
admet-737	85	58	absolute	absolute	ADJ
admet-737	85	59	quantification	quantification	NOUN
admet-737	86	1	[	[	X
admet-737	86	2	36,37	36,37	X
admet-737	86	3	]	]	X
admet-737	86	4	.	.	PUNCT
admet-737	87	1	however	however	ADV
admet-737	87	2	,	,	PUNCT
admet-737	87	3	the	the	DET
admet-737	87	4	need	need	NOUN
admet-737	87	5	for	for	ADP
admet-737	87	6	integration	integration	NOUN
admet-737	87	7	of	of	ADP
admet-737	87	8	the	the	DET
admet-737	87	9	peak	peak	NOUN
admet-737	87	10	volumes	volume	NOUN
admet-737	87	11	and	and	CCONJ
admet-737	87	12	careful	careful	ADJ
admet-737	87	13	validation	validation	NOUN
admet-737	87	14	of	of	ADP
admet-737	87	15	2d	2d	PROPN
admet-737	87	16	methods	method	NOUN
admet-737	87	17	employed[38	employed[38	NOUN
admet-737	87	18	]	]	PUNCT
admet-737	87	19	,	,	PUNCT
admet-737	87	20	are	be	AUX
admet-737	87	21	limiting	limit	VERB
admet-737	87	22	factors	factor	NOUN
admet-737	87	23	that	that	PRON
admet-737	87	24	may	may	AUX
admet-737	87	25	affect	affect	VERB
admet-737	87	26	applicability	applicability	NOUN
admet-737	87	27	of	of	ADP
admet-737	87	28	2d	2d	PROPN
admet-737	87	29	qnmr	qnmr	NOUN
admet-737	87	30	spectroscopy	spectroscopy	NOUN
admet-737	87	31	as	as	ADP
admet-737	87	32	a	a	DET
admet-737	87	33	fast	fast	ADJ
admet-737	87	34	and	and	CCONJ
admet-737	87	35	simple	simple	ADJ
admet-737	87	36	method	method	NOUN
admet-737	87	37	.	.	PUNCT
admet-737	88	1	alternatively	alternatively	ADV
admet-737	88	2	,	,	PUNCT
admet-737	88	3	diffusion	diffusion	NOUN
admet-737	88	4	-	-	PUNCT
admet-737	88	5	ordered	order	VERB
admet-737	88	6	nmr	nmr	NOUN
admet-737	88	7	spectroscopy	spectroscopy	NOUN
admet-737	88	8	(	(	PUNCT
admet-737	88	9	dosy	dosy	PROPN
admet-737	88	10	)	)	PUNCT
admet-737	88	11	can	can	AUX
admet-737	88	12	be	be	AUX
admet-737	88	13	used	use	VERB
admet-737	88	14	as	as	ADP
admet-737	88	15	2d	2d	NOUN
admet-737	88	16	method	method	NOUN
admet-737	88	17	that	that	PRON
admet-737	88	18	detects	detect	NOUN
admet-737	88	19	not	not	PART
admet-737	88	20	only	only	ADV
admet-737	88	21	association	association	NOUN
admet-737	88	22	between	between	ADP
admet-737	88	23	different	different	ADJ
admet-737	88	24	components	component	NOUN
admet-737	88	25	that	that	PRON
admet-737	88	26	may	may	AUX
admet-737	88	27	include	include	VERB
admet-737	88	28	small	small	ADJ
admet-737	88	29	compounds	compound	NOUN
admet-737	88	30	and	and	CCONJ
admet-737	88	31	polymers	polymer	NOUN
admet-737	88	32	[	[	X
admet-737	88	33	39	39	NUM
admet-737	88	34	]	]	PUNCT
admet-737	88	35	,	,	PUNCT
admet-737	88	36	but	but	CCONJ
admet-737	88	37	it	it	PRON
admet-737	88	38	can	can	AUX
admet-737	88	39	be	be	AUX
admet-737	88	40	used	use	VERB
admet-737	88	41	for	for	ADP
admet-737	88	42	quantification	quantification	NOUN
admet-737	88	43	too	too	ADV
admet-737	88	44	.	.	PUNCT
admet-737	89	1	diffusion	diffusion	NOUN
admet-737	89	2	coefficients	coefficient	NOUN
admet-737	89	3	,	,	PUNCT
admet-737	89	4	determined	determine	VERB
admet-737	89	5	by	by	ADP
admet-737	89	6	dosy	dosy	NOUN
admet-737	89	7	,	,	PUNCT
admet-737	89	8	can	can	AUX
admet-737	89	9	be	be	AUX
admet-737	89	10	used	use	VERB
admet-737	89	11	to	to	PART
admet-737	89	12	evaluate	evaluate	VERB
admet-737	89	13	solubilisation	solubilisation	NOUN
admet-737	89	14	capacity	capacity	NOUN
admet-737	89	15	of	of	ADP
admet-737	89	16	micelles	micelle	NOUN
admet-737	89	17	of	of	ADP
admet-737	89	18	sodium	sodium	NOUN
admet-737	89	19	dodecyl	dodecyl	NOUN
admet-737	89	20	sulphate	sulphate	PROPN
admet-737	89	21	(	(	PUNCT
admet-737	89	22	sds	sds	PROPN
admet-737	89	23	)	)	PUNCT
admet-737	89	24	for	for	ADP
admet-737	89	25	poorly	poorly	ADV
admet-737	89	26	soluble	soluble	ADJ
admet-737	89	27	molecules	molecule	NOUN
admet-737	89	28	such	such	ADJ
admet-737	89	29	as	as	ADP
admet-737	89	30	artemisinin	artemisinin	NOUN
admet-737	89	31	and	and	CCONJ
admet-737	89	32	curcumin	curcumin	NOUN
admet-737	89	33	.	.	PUNCT
admet-737	90	1	the	the	DET
admet-737	90	2	solubility	solubility	NOUN
admet-737	90	3	of	of	ADP
admet-737	90	4	these	these	DET
admet-737	90	5	molecules	molecule	NOUN
admet-737	90	6	can	can	AUX
admet-737	90	7	be	be	AUX
admet-737	90	8	evaluated	evaluate	VERB
admet-737	90	9	,	,	PUNCT
admet-737	90	10	individually	individually	ADV
admet-737	90	11	and	and	CCONJ
admet-737	90	12	in	in	ADP
admet-737	90	13	combination	combination	NOUN
admet-737	90	14	of	of	ADP
admet-737	90	15	different	different	ADJ
admet-737	90	16	components	component	NOUN
admet-737	90	17	by	by	ADP
admet-737	90	18	plotting	plot	VERB
admet-737	90	19	selected	select	VERB
admet-737	90	20	chemical	chemical	ADJ
admet-737	90	21	shifts	shift	NOUN
admet-737	90	22	against	against	ADP
admet-737	90	23	the	the	DET
admet-737	90	24	diffusion	diffusion	NOUN
admet-737	90	25	coefficients	coefficient	NOUN
admet-737	90	26	determined	determine	VERB
admet-737	90	27	by	by	ADP
admet-737	90	28	2d	2d	NUM
admet-737	90	29	dosy	dosy	NOUN
admet-737	90	30	spectra	spectra	NOUN
admet-737	91	1	[	[	X
admet-737	91	2	40	40	NUM
admet-737	91	3	]	]	PUNCT
admet-737	91	4	.	.	PUNCT
admet-737	92	1	furthermore	furthermore	ADV
admet-737	92	2	,	,	PUNCT
admet-737	92	3	beside	beside	ADP
admet-737	92	4	the	the	DET
admet-737	92	5	information	information	NOUN
admet-737	92	6	on	on	ADP
admet-737	92	7	solubility	solubility	NOUN
admet-737	92	8	of	of	ADP
admet-737	92	9	investigated	investigate	VERB
admet-737	92	10	compounds	compound	NOUN
admet-737	92	11	in	in	ADP
admet-737	92	12	fasted	fast	VERB
admet-737	92	13	state	state	NOUN
admet-737	92	14	simulated	simulate	VERB
admet-737	92	15	intestinal	intestinal	ADJ
admet-737	92	16	fluid	fluid	NOUN
admet-737	92	17	,	,	PUNCT
admet-737	92	18	the	the	DET
admet-737	92	19	dosy	dosy	NOUN
admet-737	92	20	spectra	spectra	PROPN
admet-737	92	21	provide	provide	VERB
admet-737	92	22	information	information	NOUN
admet-737	92	23	on	on	ADP
admet-737	92	24	diffusion	diffusion	NOUN
admet-737	92	25	properties	property	NOUN
admet-737	92	26	of	of	ADP
admet-737	92	27	micelles	micelle	NOUN
admet-737	92	28	formed	form	VERB
admet-737	92	29	by	by	ADP
admet-737	92	30	bile	bile	NOUN
admet-737	92	31	acids	acid	NOUN
admet-737	92	32	and	and	CCONJ
admet-737	92	33	poorly	poorly	ADV
admet-737	92	34	soluble	soluble	ADJ
admet-737	92	35	drugs	drug	NOUN
admet-737	92	36	[	[	X
admet-737	92	37	41	41	NUM
admet-737	92	38	]	]	PUNCT
admet-737	92	39	.	.	PUNCT
admet-737	93	1	admet	admet	PROPN
admet-737	93	2	&	&	CCONJ
admet-737	93	3	dmpk	dmpk	PROPN
admet-737	93	4	7(4	7(4	NUM
admet-737	93	5	)	)	PUNCT
admet-737	93	6	(	(	PUNCT
admet-737	93	7	2019	2019	NUM
admet-737	93	8	)	)	PUNCT
admet-737	93	9	242	242	NUM
admet-737	93	10	-	-	SYM
admet-737	93	11	251	251	NUM
admet-737	93	12	nmr	nmr	NOUN
admet-737	93	13	spectroscopy	spectroscopy	NOUN
admet-737	93	14	in	in	ADP
admet-737	93	15	drug	drug	NOUN
admet-737	93	16	discovery	discovery	NOUN
admet-737	93	17	and	and	CCONJ
admet-737	93	18	development	development	NOUN
admet-737	93	19	doi	doi	PROPN
admet-737	93	20	:	:	PUNCT
admet-737	93	21	10.5599	10.5599	NUM
admet-737	93	22	/	/	SYM
admet-737	93	23	admet.737	admet.737	PROPN
admet-737	93	24	247	247	NUM
admet-737	93	25	log	log	NOUN
admet-737	93	26	p	p	NOUN
admet-737	93	27	determination	determination	NOUN
admet-737	93	28	the	the	DET
admet-737	93	29	partition	partition	NOUN
admet-737	93	30	coefficient	coefficient	NOUN
admet-737	93	31	(	(	PUNCT
admet-737	93	32	p	p	NOUN
admet-737	93	33	)	)	PUNCT
admet-737	93	34	reflects	reflect	VERB
admet-737	93	35	the	the	DET
admet-737	93	36	different	different	ADJ
admet-737	93	37	solubility	solubility	NOUN
admet-737	93	38	of	of	ADP
admet-737	93	39	a	a	DET
admet-737	93	40	molecule	molecule	NOUN
admet-737	93	41	in	in	ADP
admet-737	93	42	two	two	NUM
admet-737	93	43	immiscible	immiscible	ADJ
admet-737	93	44	phases	phase	NOUN
admet-737	93	45	.	.	PUNCT
admet-737	94	1	the	the	DET
admet-737	94	2	logarithm	logarithm	NOUN
admet-737	94	3	of	of	ADP
admet-737	94	4	p	p	PROPN
admet-737	94	5	(	(	PUNCT
admet-737	94	6	log	log	PROPN
admet-737	94	7	p	p	X
admet-737	94	8	)	)	PUNCT
admet-737	94	9	determined	determine	VERB
admet-737	94	10	for	for	ADP
admet-737	94	11	water	water	NOUN
admet-737	94	12	and	and	CCONJ
admet-737	94	13	octanol	octanol	NOUN
admet-737	94	14	is	be	AUX
admet-737	94	15	often	often	ADV
admet-737	94	16	correlated	correlate	VERB
admet-737	94	17	with	with	ADP
admet-737	94	18	lipophilicity	lipophilicity	NOUN
admet-737	94	19	and	and	CCONJ
admet-737	94	20	of	of	ADP
admet-737	94	21	the	the	DET
admet-737	94	22	molecules	molecule	NOUN
admet-737	94	23	and	and	CCONJ
admet-737	94	24	indirectly	indirectly	ADV
admet-737	94	25	with	with	ADP
admet-737	94	26	its	its	PRON
admet-737	94	27	permeability	permeability	NOUN
admet-737	94	28	through	through	ADP
admet-737	94	29	biological	biological	ADJ
admet-737	94	30	barriers	barrier	NOUN
admet-737	94	31	.	.	PUNCT
admet-737	95	1	the	the	DET
admet-737	95	2	log	log	NOUN
admet-737	95	3	p	p	NOUN
admet-737	95	4	determination	determination	NOUN
admet-737	95	5	requires	require	VERB
admet-737	95	6	measuring	measure	VERB
admet-737	95	7	equilibration	equilibration	NOUN
admet-737	95	8	concentrations	concentration	NOUN
admet-737	95	9	of	of	ADP
admet-737	95	10	the	the	DET
admet-737	95	11	molecule	molecule	NOUN
admet-737	95	12	in	in	ADP
admet-737	95	13	water	water	NOUN
admet-737	95	14	and	and	CCONJ
admet-737	95	15	octanol	octanol	NOUN
admet-737	95	16	.	.	PUNCT
admet-737	96	1	the	the	DET
admet-737	96	2	above	above	ADV
admet-737	96	3	-	-	PUNCT
admet-737	96	4	mentioned	mention	VERB
admet-737	96	5	advantages	advantage	NOUN
admet-737	96	6	of	of	ADP
admet-737	96	7	nmr	nmr	NOUN
admet-737	96	8	,	,	PUNCT
admet-737	96	9	direct	direct	ADJ
admet-737	96	10	detection	detection	NOUN
admet-737	96	11	of	of	ADP
admet-737	96	12	analyte	analyte	NOUN
admet-737	96	13	without	without	ADP
admet-737	96	14	reliance	reliance	NOUN
admet-737	96	15	on	on	ADP
admet-737	96	16	presence	presence	NOUN
admet-737	96	17	of	of	ADP
admet-737	96	18	a	a	DET
admet-737	96	19	chromophore	chromophore	NOUN
admet-737	96	20	,	,	PUNCT
admet-737	96	21	simple	simple	ADJ
admet-737	96	22	data	datum	NOUN
admet-737	96	23	interpretation	interpretation	NOUN
admet-737	96	24	,	,	PUNCT
admet-737	96	25	and	and	CCONJ
admet-737	96	26	minimal	minimal	ADJ
admet-737	96	27	sample	sample	NOUN
admet-737	96	28	preparation	preparation	NOUN
admet-737	96	29	,	,	PUNCT
admet-737	96	30	can	can	AUX
admet-737	96	31	be	be	AUX
admet-737	96	32	used	use	VERB
admet-737	96	33	in	in	ADP
admet-737	96	34	determination	determination	NOUN
admet-737	96	35	of	of	ADP
admet-737	96	36	log	log	NOUN
admet-737	96	37	p.	p.	NOUN
admet-737	96	38	if	if	SCONJ
admet-737	96	39	a	a	DET
admet-737	96	40	drug	drug	NOUN
admet-737	96	41	,	,	PUNCT
admet-737	96	42	or	or	CCONJ
admet-737	96	43	a	a	DET
admet-737	96	44	drug	drug	NOUN
admet-737	96	45	candidate	candidate	NOUN
admet-737	96	46	,	,	PUNCT
admet-737	96	47	has	have	VERB
admet-737	96	48	the	the	DET
admet-737	96	49	aqueous	aqueous	ADJ
admet-737	96	50	solubility	solubility	NOUN
admet-737	96	51	higher	high	ADJ
admet-737	96	52	than	than	ADP
admet-737	96	53	the	the	DET
admet-737	96	54	limit	limit	NOUN
admet-737	96	55	of	of	ADP
admet-737	96	56	quantification	quantification	NOUN
admet-737	96	57	by	by	ADP
admet-737	96	58	qnmr	qnmr	NOUN
admet-737	96	59	,	,	PUNCT
admet-737	96	60	its	its	PRON
admet-737	96	61	concentration	concentration	NOUN
admet-737	96	62	in	in	ADP
admet-737	96	63	water	water	NOUN
admet-737	96	64	and	and	CCONJ
admet-737	96	65	octanol	octanol	NOUN
admet-737	96	66	can	can	AUX
admet-737	96	67	be	be	AUX
admet-737	96	68	determined	determine	VERB
admet-737	96	69	directly	directly	ADV
admet-737	96	70	after	after	ADP
admet-737	96	71	separation	separation	NOUN
admet-737	96	72	and	and	CCONJ
admet-737	96	73	without	without	ADP
admet-737	96	74	the	the	DET
admet-737	96	75	need	need	NOUN
admet-737	96	76	for	for	ADP
admet-737	96	77	calibration	calibration	NOUN
admet-737	96	78	curve	curve	NOUN
admet-737	97	1	[	[	X
admet-737	97	2	42	42	NUM
admet-737	97	3	]	]	PUNCT
admet-737	97	4	.	.	PUNCT
admet-737	98	1	this	this	DET
admet-737	98	2	approach	approach	NOUN
admet-737	98	3	can	can	AUX
admet-737	98	4	be	be	AUX
admet-737	98	5	applied	apply	VERB
admet-737	98	6	after	after	ADP
admet-737	98	7	compound	compound	NOUN
admet-737	98	8	partitioning	partitioning	NOUN
admet-737	98	9	between	between	ADP
admet-737	98	10	water	water	NOUN
admet-737	98	11	and	and	CCONJ
admet-737	98	12	1‐octanol	1‐octanol	NOUN
admet-737	98	13	using	use	VERB
admet-737	98	14	standard	standard	ADJ
admet-737	98	15	methods	method	NOUN
admet-737	98	16	by	by	ADP
admet-737	98	17	taking	take	VERB
admet-737	98	18	aliquots	aliquot	NOUN
admet-737	98	19	from	from	ADP
admet-737	98	20	two	two	NUM
admet-737	98	21	layers	layer	NOUN
admet-737	98	22	.	.	PUNCT
admet-737	99	1	the	the	DET
admet-737	99	2	signal	signal	ADJ
admet-737	99	3	amplitudes	amplitude	NOUN
admet-737	99	4	extracted	extract	VERB
admet-737	99	5	the	the	DET
admet-737	99	6	a	a	DET
admet-737	99	7	compound	compound	NOUN
admet-737	99	8	from	from	ADP
admet-737	99	9	each	each	PRON
admet-737	99	10	can	can	AUX
admet-737	99	11	be	be	AUX
admet-737	99	12	analyzed	analyze	VERB
admet-737	99	13	using	use	VERB
admet-737	99	14	the	the	DET
admet-737	99	15	craft	craft	NOUN
admet-737	99	16	software	software	NOUN
admet-737	99	17	,	,	PUNCT
admet-737	99	18	that	that	PRON
admet-737	99	19	directly	directly	ADV
admet-737	99	20	calculates	calculate	VERB
admet-737	99	21	both	both	PRON
admet-737	99	22	log	log	VERB
admet-737	99	23	p	p	NOUN
admet-737	99	24	and	and	CCONJ
admet-737	99	25	log	log	VERB
admet-737	99	26	d7.4	d7.4	NOUN
admet-737	99	27	values	value	NOUN
admet-737	99	28	[	[	X
admet-737	99	29	43	43	NUM
admet-737	99	30	]	]	PUNCT
admet-737	99	31	.	.	PUNCT
admet-737	100	1	the	the	DET
admet-737	100	2	similar	similar	ADJ
admet-737	100	3	experiment	experiment	NOUN
admet-737	100	4	can	can	AUX
admet-737	100	5	be	be	AUX
admet-737	100	6	conducted	conduct	VERB
admet-737	100	7	directly	directly	ADV
admet-737	100	8	in	in	ADP
admet-737	100	9	the	the	DET
admet-737	100	10	nmr	nmr	NOUN
admet-737	100	11	tube	tube	NOUN
admet-737	100	12	by	by	ADP
admet-737	100	13	mini	mini	ADJ
admet-737	100	14	shake	shake	NOUN
admet-737	100	15	-	-	PUNCT
admet-737	100	16	flask	flask	NOUN
admet-737	100	17	approach	approach	NOUN
admet-737	100	18	,	,	PUNCT
admet-737	100	19	where	where	SCONJ
admet-737	100	20	the	the	DET
admet-737	100	21	initial	initial	ADJ
admet-737	100	22	determination	determination	NOUN
admet-737	100	23	of	of	ADP
admet-737	100	24	equilibrium	equilibrium	NOUN
admet-737	100	25	concentrations	concentration	NOUN
admet-737	100	26	of	of	ADP
admet-737	100	27	an	an	DET
admet-737	100	28	analyte	analyte	NOUN
admet-737	100	29	in	in	ADP
admet-737	100	30	water	water	NOUN
admet-737	100	31	is	be	AUX
admet-737	100	32	followed	follow	VERB
admet-737	100	33	by	by	ADP
admet-737	100	34	addition	addition	NOUN
admet-737	100	35	of	of	ADP
admet-737	100	36	the	the	DET
admet-737	100	37	octanol	octanol	NOUN
admet-737	100	38	layer	layer	NOUN
admet-737	100	39	and	and	CCONJ
admet-737	100	40	equilibration	equilibration	NOUN
admet-737	100	41	of	of	ADP
admet-737	100	42	the	the	DET
admet-737	100	43	sample	sample	NOUN
admet-737	100	44	(	(	PUNCT
admet-737	100	45	figure	figure	NOUN
admet-737	100	46	3	3	NUM
admet-737	100	47	)	)	PUNCT
admet-737	100	48	.	.	PUNCT
admet-737	101	1	the	the	DET
admet-737	101	2	measurement	measurement	NOUN
admet-737	101	3	the	the	DET
admet-737	101	4	concentrations	concentration	NOUN
admet-737	101	5	of	of	ADP
admet-737	101	6	the	the	DET
admet-737	101	7	analyte	analyte	NOUN
admet-737	101	8	a	a	PRON
admet-737	101	9	in	in	ADP
admet-737	101	10	the	the	DET
admet-737	101	11	water	water	NOUN
admet-737	101	12	phase	phase	NOUN
admet-737	101	13	before	before	ADV
admet-737	101	14	and	and	CCONJ
admet-737	101	15	after	after	ADP
admet-737	101	16	equilibration	equilibration	NOUN
admet-737	101	17	.	.	PUNCT
admet-737	102	1	the	the	DET
admet-737	102	2	concentration	concentration	NOUN
admet-737	102	3	of	of	ADP
admet-737	102	4	the	the	DET
admet-737	102	5	analyte	analyte	NOUN
admet-737	102	6	can	can	AUX
admet-737	102	7	be	be	AUX
admet-737	102	8	calculated	calculate	VERB
admet-737	102	9	as	as	ADP
admet-737	102	10	the	the	DET
admet-737	102	11	difference	difference	NOUN
admet-737	102	12	between	between	ADP
admet-737	102	13	the	the	DET
admet-737	102	14	amount	amount	NOUN
admet-737	102	15	of	of	ADP
admet-737	102	16	analyte	analyte	NOUN
admet-737	102	17	in	in	ADP
admet-737	102	18	water	water	NOUN
admet-737	102	19	before	before	ADP
admet-737	102	20	and	and	CCONJ
admet-737	102	21	after	after	ADP
admet-737	102	22	equilibration	equilibration	NOUN
admet-737	102	23	step	step	NOUN
admet-737	102	24	[	[	X
admet-737	102	25	44	44	NUM
admet-737	102	26	]	]	PUNCT
admet-737	102	27	.	.	PUNCT
admet-737	103	1	this	this	DET
admet-737	103	2	approach	approach	NOUN
admet-737	103	3	could	could	AUX
admet-737	103	4	easily	easily	ADV
admet-737	103	5	be	be	AUX
admet-737	103	6	implemented	implement	VERB
admet-737	103	7	as	as	ADP
admet-737	103	8	a	a	DET
admet-737	103	9	follow	follow	NOUN
admet-737	103	10	up	up	ADP
admet-737	103	11	step	step	NOUN
admet-737	103	12	to	to	ADP
admet-737	103	13	solubility	solubility	NOUN
admet-737	103	14	determination	determination	NOUN
admet-737	103	15	of	of	ADP
admet-737	103	16	drug	drug	NOUN
admet-737	103	17	candidates	candidate	NOUN
admet-737	103	18	and	and	CCONJ
admet-737	103	19	be	be	AUX
admet-737	103	20	possibly	possibly	ADV
admet-737	103	21	incorporated	incorporate	VERB
admet-737	103	22	in	in	ADP
admet-737	103	23	automation	automation	NOUN
admet-737	103	24	assays	assay	NOUN
admet-737	103	25	that	that	PRON
admet-737	103	26	use	use	VERB
admet-737	103	27	nmr	nmr	NOUN
admet-737	103	28	spectroscopy	spectroscopy	NOUN
admet-737	103	29	.	.	PUNCT
admet-737	104	1	measurement	measurement	NOUN
admet-737	104	2	of	of	ADP
admet-737	104	3	log	log	PROPN
admet-737	104	4	 	 	SPACE
admet-737	104	5	p	p	NOUN
admet-737	104	6	for	for	ADP
admet-737	104	7	fluorinated	fluorinate	VERB
admet-737	104	8	compounds	compound	NOUN
admet-737	104	9	can	can	AUX
admet-737	104	10	employ	employ	VERB
admet-737	104	11	19f	19f	NUM
admet-737	104	12	nmr	nmr	NOUN
admet-737	104	13	spectroscopy	spectroscopy	NOUN
admet-737	104	14	in	in	ADP
admet-737	104	15	addition	addition	NOUN
admet-737	104	16	to	to	ADP
admet-737	104	17	1h	1h	NUM
admet-737	104	18	nmr	nmr	NOUN
admet-737	104	19	spectroscopy	spectroscopy	NOUN
admet-737	104	20	.	.	PUNCT
admet-737	105	1	using	use	VERB
admet-737	105	2	similar	similar	ADJ
admet-737	105	3	procedures	procedure	NOUN
admet-737	105	4	to	to	PART
admet-737	105	5	previously	previously	ADV
admet-737	105	6	described	describe	VERB
admet-737	105	7	procedures	procedure	NOUN
admet-737	105	8	,	,	PUNCT
admet-737	105	9	there	there	PRON
admet-737	105	10	is	be	VERB
admet-737	105	11	no	no	DET
admet-737	105	12	need	need	NOUN
admet-737	105	13	for	for	ADP
admet-737	105	14	calibration	calibration	NOUN
admet-737	105	15	curves	curve	NOUN
admet-737	105	16	providing	provide	VERB
admet-737	105	17	a	a	DET
admet-737	105	18	straightforward	straightforward	ADJ
admet-737	105	19	method	method	NOUN
admet-737	105	20	for	for	ADP
admet-737	105	21	the	the	DET
admet-737	105	22	measurement	measurement	NOUN
admet-737	105	23	of	of	ADP
admet-737	105	24	lipophilicity	lipophilicity	NOUN
admet-737	105	25	of	of	ADP
admet-737	105	26	fluorinated	fluorinate	VERB
admet-737	105	27	compounds	compound	NOUN
admet-737	105	28	[	[	X
admet-737	105	29	45,46	45,46	NOUN
admet-737	105	30	]	]	PUNCT
admet-737	105	31	.	.	PUNCT
admet-737	106	1	figure	figure	NOUN
admet-737	106	2	3	3	NUM
admet-737	106	3	.	.	PUNCT
admet-737	106	4	schematic	schematic	ADJ
admet-737	106	5	diagram	diagram	NOUN
admet-737	106	6	of	of	ADP
admet-737	106	7	the	the	DET
admet-737	106	8	analyte	analyte	NOUN
admet-737	106	9	partition	partition	NOUN
admet-737	106	10	between	between	ADP
admet-737	106	11	the	the	DET
admet-737	106	12	water	water	NOUN
admet-737	106	13	and	and	CCONJ
admet-737	106	14	1	1	NUM
admet-737	106	15	-	-	PUNCT
admet-737	106	16	octanol	octanol	NOUN
admet-737	106	17	layers	layer	NOUN
admet-737	106	18	upon	upon	SCONJ
admet-737	106	19	equilibration	equilibration	NOUN
admet-737	106	20	.	.	PUNCT
admet-737	107	1	taken	take	VERB
admet-737	107	2	with	with	ADP
admet-737	107	3	permission	permission	NOUN
admet-737	107	4	from	from	ADP
admet-737	107	5	[	[	X
admet-737	107	6	44	44	NUM
admet-737	107	7	]	]	PUNCT
admet-737	107	8	(	(	PUNCT
admet-737	107	9	https://doi.org/10.1021/acsomega.7b01102	https://doi.org/10.1021/acsomega.7b01102	NUM
admet-737	107	10	)	)	PUNCT
admet-737	107	11	and	and	CCONJ
admet-737	107	12	further	further	ADJ
admet-737	107	13	requests	request	NOUN
admet-737	107	14	for	for	ADP
admet-737	107	15	permission	permission	NOUN
admet-737	107	16	should	should	AUX
admet-737	107	17	be	be	AUX
admet-737	107	18	directed	direct	VERB
admet-737	107	19	to	to	ADP
admet-737	107	20	acs	acs	PROPN
admet-737	107	21	.	.	PUNCT
admet-737	107	22	.	.	PUNCT
admet-737	108	1	pka	pka	PROPN
admet-737	108	2	determination	determination	NOUN
admet-737	108	3	the	the	DET
admet-737	108	4	acid	acid	NOUN
admet-737	108	5	-	-	PUNCT
admet-737	108	6	base	base	NOUN
admet-737	108	7	dissociation	dissociation	NOUN
admet-737	108	8	constant	constant	ADJ
admet-737	108	9	(	(	PUNCT
admet-737	108	10	pka	pka	NOUN
admet-737	108	11	)	)	PUNCT
admet-737	108	12	of	of	ADP
admet-737	108	13	a	a	DET
admet-737	108	14	drug	drug	NOUN
admet-737	108	15	is	be	AUX
admet-737	108	16	also	also	ADV
admet-737	108	17	a	a	DET
admet-737	108	18	physicochemical	physicochemical	ADJ
admet-737	108	19	parameter	parameter	NOUN
admet-737	108	20	that	that	PRON
admet-737	108	21	affects	affect	VERB
admet-737	108	22	many	many	ADJ
admet-737	108	23	of	of	ADP
admet-737	108	24	its	its	PRON
admet-737	108	25	biophysical	biophysical	ADJ
admet-737	108	26	characteristics	characteristic	NOUN
admet-737	108	27	.	.	PUNCT
admet-737	109	1	,	,	PUNCT
admet-737	109	2	including	include	VERB
admet-737	109	3	solubility	solubility	NOUN
admet-737	109	4	,	,	PUNCT
admet-737	109	5	lipophilicity	lipophilicity	NOUN
admet-737	109	6	,	,	PUNCT
admet-737	109	7	binding	bind	VERB
admet-737	109	8	to	to	ADP
admet-737	109	9	proteins	protein	NOUN
admet-737	109	10	and	and	CCONJ
admet-737	109	11	crossing	cross	VERB
admet-737	109	12	biological	biological	ADJ
admet-737	109	13	barriers	barrier	NOUN
admet-737	109	14	.	.	PUNCT
admet-737	110	1	the	the	DET
admet-737	110	2	pka	pka	PROPN
admet-737	110	3	determination	determination	NOUN
admet-737	110	4	involves	involve	VERB
admet-737	110	5	monitoring	monitor	VERB
admet-737	110	6	the	the	DET
admet-737	110	7	ionization	ionization	NOUN
admet-737	110	8	state	state	NOUN
admet-737	110	9	of	of	ADP
admet-737	110	10	a	a	DET
admet-737	110	11	molecule	molecule	NOUN
admet-737	110	12	with	with	ADP
admet-737	110	13	changing	change	VERB
admet-737	110	14	ph	ph	ADJ
admet-737	110	15	.	.	PROPN
admet-737	110	16	traditional	traditional	ADJ
admet-737	110	17	methods	method	NOUN
admet-737	110	18	,	,	PUNCT
admet-737	110	19	such	such	ADJ
admet-737	110	20	as	as	ADP
admet-737	110	21	potentiometric	potentiometric	ADJ
admet-737	110	22	titrations	titration	NOUN
admet-737	110	23	or	or	CCONJ
admet-737	110	24	following	follow	VERB
admet-737	110	25	the	the	DET
admet-737	110	26	change	change	NOUN
admet-737	110	27	of	of	ADP
admet-737	110	28	uv	uv	NOUN
admet-737	110	29	absorption	absorption	NOUN
admet-737	110	30	as	as	ADP
admet-737	110	31	a	a	DET
admet-737	110	32	function	function	NOUN
admet-737	110	33	of	of	ADP
admet-737	110	34	ph	ph	NOUN
admet-737	110	35	,	,	PUNCT
admet-737	110	36	involve	involve	VERB
admet-737	110	37	complex	complex	ADJ
admet-737	110	38	experimental	experimental	ADJ
admet-737	110	39	setup	setup	NOUN
admet-737	110	40	and	and	CCONJ
admet-737	110	41	analyses	analysis	NOUN
admet-737	110	42	of	of	ADP
admet-737	110	43	results	result	NOUN
admet-737	110	44	.	.	PUNCT
admet-737	111	1	nmr	nmr	NOUN
admet-737	111	2	spectroscopy	spectroscopy	NOUN
admet-737	111	3	is	be	AUX
admet-737	111	4	also	also	ADV
admet-737	111	5	based	base	VERB
admet-737	111	6	on	on	ADP
admet-737	111	7	analysis	analysis	NOUN
admet-737	111	8	of	of	ADP
admet-737	111	9	protonation	protonation	NOUN
admet-737	111	10	degree	degree	NOUN
admet-737	111	11	of	of	ADP
admet-737	111	12	a	a	DET
admet-737	111	13	molecule	molecule	NOUN
admet-737	111	14	with	with	ADP
admet-737	111	15	changing	change	VERB
admet-737	111	16	ph	ph	NOUN
admet-737	111	17	.	.	PUNCT
admet-737	112	1	the	the	DET
admet-737	112	2	protonation	protonation	NOUN
admet-737	112	3	degree	degree	NOUN
admet-737	112	4	is	be	AUX
admet-737	112	5	monitored	monitor	VERB
admet-737	112	6	either	either	CCONJ
admet-737	112	7	by	by	ADP
admet-737	112	8	the	the	DET
admet-737	112	9	chemical	chemical	NOUN
admet-737	112	10	shift	shift	NOUN
admet-737	112	11	changes	change	NOUN
admet-737	112	12	close	close	ADJ
admet-737	112	13	to	to	ADP
admet-737	112	14	the	the	DET
admet-737	112	15	acidic	acidic	ADJ
admet-737	112	16	or	or	CCONJ
admet-737	112	17	basic	basic	ADJ
admet-737	112	18	regions	region	NOUN
admet-737	112	19	of	of	ADP
admet-737	112	20	molecule	molecule	NOUN
admet-737	112	21	[	[	X
admet-737	112	22	47	47	NUM
admet-737	112	23	]	]	PUNCT
admet-737	112	24	or	or	CCONJ
admet-737	112	25	via	via	ADP
admet-737	112	26	changes	change	NOUN
admet-737	112	27	of	of	ADP
admet-737	112	28	the	the	DET
admet-737	112	29	integration	integration	NOUN
admet-737	112	30	values	value	NOUN
admet-737	112	31	of	of	ADP
admet-737	112	32	peaks	peak	NOUN
admet-737	112	33	that	that	PRON
admet-737	112	34	arise	arise	VERB
admet-737	112	35	from	from	ADP
admet-737	112	36	ionizable	ionizable	ADJ
admet-737	112	37	groups	group	NOUN
admet-737	112	38	(	(	PUNCT
admet-737	112	39	figure	figure	VERB
admet-737	112	40	4	4	NUM
admet-737	112	41	)	)	PUNCT
admet-737	113	1	[	[	X
admet-737	113	2	48	48	NUM
admet-737	113	3	]	]	PUNCT
admet-737	113	4	.	.	PUNCT
admet-737	114	1	https://doi.org/10.1021/acsomega.7b01102	https://doi.org/10.1021/acsomega.7b01102	DET
admet-737	114	2	mire	mire	NOUN
admet-737	114	3	zloh	zloh	PROPN
admet-737	114	4	admet	admet	PROPN
admet-737	114	5	&	&	CCONJ
admet-737	114	6	dmpk	dmpk	PROPN
admet-737	114	7	7(4	7(4	NUM
admet-737	114	8	)	)	PUNCT
admet-737	114	9	(	(	PUNCT
admet-737	114	10	2019	2019	NUM
admet-737	114	11	)	)	PUNCT
admet-737	114	12	242	242	NUM
admet-737	114	13	-	-	SYM
admet-737	114	14	251	251	NUM
admet-737	114	15	248	248	NUM
admet-737	114	16	figure	figure	NOUN
admet-737	114	17	4	4	NUM
admet-737	114	18	.	.	PUNCT
admet-737	114	19	different	different	ADJ
admet-737	114	20	ph	ph	NOUN
admet-737	114	21	value	value	NOUN
admet-737	114	22	1	1	NUM
admet-737	114	23	h	h	NOUN
admet-737	114	24	nmr	nmr	NOUN
admet-737	114	25	spectrums	spectrum	NOUN
admet-737	114	26	obtained	obtain	VERB
admet-737	114	27	by	by	ADP
admet-737	114	28	the	the	DET
admet-737	114	29	10	10	NUM
admet-737	114	30	 	 	SPACE
admet-737	114	31	mm	mm	PROPN
admet-737	114	32	tetrabutylammonium	tetrabutylammonium	NOUN
admet-737	114	33	hydroxide	hydroxide	NOUN
admet-737	114	34	solution	solution	NOUN
admet-737	114	35	(	(	PUNCT
admet-737	114	36	tbah	tbah	NOUN
admet-737	114	37	)	)	PUNCT
admet-737	114	38	titration	titration	NOUN
admet-737	114	39	of	of	ADP
admet-737	114	40	1‐[2‐(4‐methoxyphenyl)ethyl]‐3‐methylbenzimidazolium	1‐[2‐(4‐methoxyphenyl)ethyl]‐3‐methylbenzimidazolium	NUM
admet-737	114	41	iodide	iodide	NOUN
admet-737	114	42	(	(	PUNCT
admet-737	114	43	2	2	X
admet-737	114	44	)	)	PUNCT
admet-737	114	45	compound	compound	NOUN
admet-737	114	46	in	in	ADP
admet-737	114	47	10	10	NUM
admet-737	114	48	 	 	SPACE
admet-737	114	49	mm	mm	NOUN
admet-737	114	50	solution	solution	NOUN
admet-737	114	51	and	and	CCONJ
admet-737	114	52	the	the	DET
admet-737	114	53	sigmoidal	sigmoidal	NOUN
admet-737	114	54	curve	curve	NOUN
admet-737	114	55	that	that	PRON
admet-737	114	56	was	be	AUX
admet-737	114	57	acquired	acquire	VERB
admet-737	114	58	with	with	ADP
admet-737	114	59	the	the	DET
admet-737	114	60	passing	passing	NOUN
admet-737	114	61	of	of	ADP
admet-737	114	62	integral	integral	ADJ
admet-737	114	63	values	value	NOUN
admet-737	114	64	obtained	obtain	VERB
admet-737	114	65	from	from	ADP
admet-737	114	66	these	these	DET
admet-737	114	67	spectrums	spectrum	NOUN
admet-737	114	68	to	to	ADP
admet-737	114	69	the	the	PRON
admet-737	114	70	against	against	ADP
admet-737	114	71	ph	ph	ADJ
admet-737	114	72	values	value	NOUN
admet-737	114	73	.	.	PUNCT
admet-737	115	1	taken	take	VERB
admet-737	115	2	with	with	ADP
admet-737	115	3	permission	permission	NOUN
admet-737	115	4	from	from	ADP
admet-737	115	5	[	[	X
admet-737	115	6	48	48	NUM
admet-737	115	7	]	]	PUNCT
admet-737	115	8	.	.	PUNCT
admet-737	116	1	copyright	copyright	NOUN
admet-737	116	2	(	(	PUNCT
admet-737	116	3	2019	2019	NUM
admet-737	116	4	)	)	PUNCT
admet-737	116	5	with	with	ADP
admet-737	116	6	permission	permission	NOUN
admet-737	116	7	from	from	ADP
admet-737	116	8	wiley	wiley	PROPN
admet-737	116	9	.	.	PUNCT
admet-737	117	1	conclusions	conclusion	NOUN
admet-737	117	2	the	the	DET
admet-737	117	3	nmr	nmr	NOUN
admet-737	117	4	spectroscopy	spectroscopy	NOUN
admet-737	117	5	is	be	AUX
admet-737	117	6	extensively	extensively	ADV
admet-737	117	7	used	use	VERB
admet-737	117	8	in	in	ADP
admet-737	117	9	the	the	DET
admet-737	117	10	various	various	ADJ
admet-737	117	11	drug	drug	NOUN
admet-737	117	12	discovery	discovery	NOUN
admet-737	117	13	and	and	CCONJ
admet-737	117	14	development	development	NOUN
admet-737	117	15	process	process	NOUN
admet-737	117	16	,	,	PUNCT
admet-737	117	17	however	however	ADV
admet-737	117	18	further	further	ADJ
admet-737	117	19	applications	application	NOUN
admet-737	117	20	of	of	ADP
admet-737	117	21	qnmr	qnmr	NOUN
admet-737	117	22	can	can	AUX
admet-737	117	23	have	have	VERB
admet-737	117	24	a	a	DET
admet-737	117	25	significant	significant	ADJ
admet-737	117	26	impact	impact	NOUN
admet-737	117	27	on	on	ADP
admet-737	117	28	the	the	DET
admet-737	117	29	early	early	ADJ
admet-737	117	30	stages	stage	NOUN
admet-737	117	31	of	of	ADP
admet-737	117	32	selection	selection	NOUN
admet-737	117	33	of	of	ADP
admet-737	117	34	lead	lead	NOUN
admet-737	117	35	compounds	compound	NOUN
admet-737	117	36	with	with	ADP
admet-737	117	37	adequate	adequate	ADJ
admet-737	117	38	adme	adme	NOUN
admet-737	117	39	properties	property	NOUN
admet-737	117	40	.	.	PUNCT
admet-737	118	1	furthermore	furthermore	ADV
admet-737	118	2	,	,	PUNCT
admet-737	118	3	the	the	DET
admet-737	118	4	determination	determination	NOUN
admet-737	118	5	of	of	ADP
admet-737	118	6	physico	physico	NOUN
admet-737	118	7	-	-	PUNCT
admet-737	118	8	chemical	chemical	NOUN
admet-737	118	9	properties	property	NOUN
admet-737	118	10	is	be	AUX
admet-737	118	11	not	not	PART
admet-737	118	12	affected	affect	VERB
admet-737	118	13	by	by	ADP
admet-737	118	14	the	the	DET
admet-737	118	15	presence	presence	NOUN
admet-737	118	16	of	of	ADP
admet-737	118	17	other	other	ADJ
admet-737	118	18	components	component	NOUN
admet-737	118	19	,	,	PUNCT
admet-737	118	20	moreover	moreover	ADV
admet-737	118	21	it	it	PRON
admet-737	118	22	may	may	AUX
admet-737	118	23	provide	provide	VERB
admet-737	118	24	significant	significant	ADJ
admet-737	118	25	information	information	NOUN
admet-737	118	26	on	on	ADP
admet-737	118	27	behaviour	behaviour	NOUN
admet-737	118	28	of	of	ADP
admet-737	118	29	molecules	molecule	NOUN
admet-737	118	30	in	in	ADP
admet-737	118	31	environments	environment	NOUN
admet-737	118	32	that	that	PRON
admet-737	118	33	are	be	AUX
admet-737	118	34	more	more	ADV
admet-737	118	35	similar	similar	ADJ
admet-737	118	36	to	to	ADP
admet-737	118	37	conditions	condition	NOUN
admet-737	118	38	in	in	ADP
admet-737	118	39	in	in	ADP
admet-737	118	40	vitro	vitro	X
admet-737	118	41	and	and	CCONJ
admet-737	118	42	possibly	possibly	ADV
admet-737	118	43	in	in	ADP
admet-737	118	44	vivo	vivo	ADJ
admet-737	118	45	experiments	experiment	NOUN
admet-737	118	46	.	.	PUNCT
admet-737	119	1	despite	despite	SCONJ
admet-737	119	2	first	first	ADJ
admet-737	119	3	nmr	nmr	NOUN
admet-737	119	4	signals	signal	NOUN
admet-737	119	5	discovered	discover	VERB
admet-737	119	6	over	over	ADP
admet-737	119	7	70	70	NUM
admet-737	119	8	years	year	NOUN
admet-737	119	9	ago	ago	ADV
admet-737	119	10	,	,	PUNCT
admet-737	119	11	the	the	DET
admet-737	119	12	development	development	NOUN
admet-737	119	13	of	of	ADP
admet-737	119	14	new	new	ADJ
admet-737	119	15	approaches	approach	NOUN
admet-737	119	16	in	in	ADP
admet-737	119	17	solving	solving	NOUN
admet-737	119	18	of	of	ADP
admet-737	119	19	real	real	ADJ
admet-737	119	20	-	-	PUNCT
admet-737	119	21	life	life	NOUN
admet-737	119	22	problems	problem	NOUN
admet-737	119	23	is	be	AUX
admet-737	119	24	still	still	ADV
admet-737	119	25	undergoing	undergo	VERB
admet-737	119	26	and	and	CCONJ
admet-737	119	27	it	it	PRON
admet-737	119	28	has	have	VERB
admet-737	119	29	a	a	DET
admet-737	119	30	potential	potential	NOUN
admet-737	119	31	to	to	PART
admet-737	119	32	play	play	VERB
admet-737	119	33	even	even	ADV
admet-737	119	34	greater	great	ADJ
admet-737	119	35	role	role	NOUN
admet-737	119	36	in	in	ADP
admet-737	119	37	the	the	DET
admet-737	119	38	future	future	ADJ
admet-737	119	39	drug	drug	NOUN
admet-737	119	40	discovery	discovery	NOUN
admet-737	119	41	programmes	programme	NOUN
admet-737	119	42	.	.	PUNCT
admet-737	120	1	conflict	conflict	NOUN
admet-737	120	2	of	of	ADP
admet-737	120	3	interest	interest	NOUN
admet-737	120	4	:	:	PUNCT
admet-737	120	5	the	the	DET
admet-737	120	6	author	author	NOUN
admet-737	120	7	declares	declare	VERB
admet-737	120	8	no	no	DET
admet-737	120	9	conflict	conflict	NOUN
admet-737	120	10	of	of	ADP
admet-737	120	11	interest	interest	NOUN
admet-737	120	12	.	.	PUNCT
admet-737	121	1	references	reference	NOUN
admet-737	121	2	[	[	X
admet-737	121	3	1	1	NUM
admet-737	121	4	]	]	X
admet-737	121	5	j.l	j.l	PROPN
admet-737	121	6	.	.	PROPN
admet-737	121	7	koh	koh	PROPN
admet-737	121	8	,	,	PUNCT
admet-737	121	9	d.	d.	PROPN
admet-737	121	10	gottfried	gottfried	PROPN
admet-737	121	11	,	,	PUNCT
admet-737	121	12	d.r	d.r	PROPN
admet-737	121	13	.	.	PROPN
admet-737	121	14	lee	lee	PROPN
admet-737	121	15	,	,	PUNCT
admet-737	121	16	s.	s.	PROPN
admet-737	121	17	navarrete	navarrete	PROPN
admet-737	121	18	,	,	PUNCT
admet-737	121	19	understanding	understand	VERB
admet-737	121	20	and	and	CCONJ
admet-737	121	21	addressing	address	VERB
admet-737	121	22	regulatory	regulatory	ADJ
admet-737	121	23	concerns	concern	NOUN
admet-737	121	24	in	in	ADP
admet-737	121	25	research	research	NOUN
admet-737	121	26	,	,	PUNCT
admet-737	121	27	basic	basic	ADJ
admet-737	121	28	methods	method	NOUN
admet-737	121	29	handbook	handbook	VERB
admet-737	121	30	for	for	ADP
admet-737	121	31	clinical	clinical	ADJ
admet-737	121	32	orthopaedic	orthopaedic	ADJ
admet-737	121	33	research	research	NOUN
admet-737	121	34	,	,	PUNCT
admet-737	121	35	springer2019	springer2019	PROPN
admet-737	121	36	,	,	PUNCT
admet-737	121	37	pp	pp	X
admet-737	121	38	.	.	PUNCT
admet-737	122	1	515	515	NUM
admet-737	122	2	-	-	SYM
admet-737	122	3	531	531	NUM
admet-737	122	4	.	.	PUNCT
admet-737	123	1	[	[	X
admet-737	123	2	2	2	NUM
admet-737	123	3	]	]	X
admet-737	123	4	b.	b.	PROPN
admet-737	123	5	g	g	PROPN
admet-737	123	6	de	de	PROPN
admet-737	123	7	la	la	X
admet-737	123	8	torre	torre	PROPN
admet-737	123	9	,	,	PUNCT
admet-737	123	10	f.	f.	PROPN
admet-737	123	11	albericio	albericio	PROPN
admet-737	123	12	.	.	PUNCT
admet-737	124	1	the	the	DET
admet-737	124	2	pharmaceutical	pharmaceutical	NOUN
admet-737	124	3	industry	industry	NOUN
admet-737	124	4	in	in	ADP
admet-737	124	5	2018	2018	NUM
admet-737	124	6	.	.	PUNCT
admet-737	125	1	an	an	DET
admet-737	125	2	analysis	analysis	NOUN
admet-737	125	3	of	of	ADP
admet-737	125	4	fda	fda	PROPN
admet-737	125	5	drug	drug	NOUN
admet-737	125	6	approvals	approval	NOUN
admet-737	125	7	from	from	ADP
admet-737	125	8	the	the	DET
admet-737	125	9	perspective	perspective	NOUN
admet-737	125	10	of	of	ADP
admet-737	125	11	molecules	molecule	NOUN
admet-737	125	12	.	.	PUNCT
admet-737	126	1	molecules	molecule	NOUN
admet-737	126	2	24	24	NUM
admet-737	126	3	(	(	PUNCT
admet-737	126	4	2019	2019	NUM
admet-737	126	5	)	)	PUNCT
admet-737	126	6	e809	e809	PROPN
admet-737	126	7	.	.	PUNCT
admet-737	127	1	[	[	X
admet-737	127	2	3	3	X
admet-737	127	3	]	]	X
admet-737	127	4	s.	s.	PROPN
admet-737	127	5	bendels	bendels	PROPN
admet-737	127	6	,	,	PUNCT
admet-737	127	7	c.	c.	PROPN
admet-737	127	8	bissantz	bissantz	PROPN
admet-737	127	9	,	,	PUNCT
admet-737	127	10	b.	b.	PROPN
admet-737	127	11	fasching	fasching	PROPN
admet-737	127	12	,	,	PUNCT
admet-737	127	13	g.	g.	PROPN
admet-737	127	14	gerebtzoff	gerebtzoff	PROPN
admet-737	127	15	,	,	PUNCT
admet-737	127	16	w.	w.	PROPN
admet-737	127	17	guba	guba	PROPN
admet-737	127	18	,	,	PUNCT
admet-737	127	19	m.	m.	PROPN
admet-737	127	20	kansy	kansy	PROPN
admet-737	127	21	,	,	PUNCT
admet-737	127	22	j.	j.	PROPN
admet-737	127	23	migeon	migeon	PROPN
admet-737	127	24	,	,	PUNCT
admet-737	127	25	s.	s.	PROPN
admet-737	127	26	mohr	mohr	PROPN
admet-737	127	27	,	,	PUNCT
admet-737	127	28	j.-u	j.-u	PROPN
admet-737	127	29	.	.	PUNCT
admet-737	128	1	peters	peters	PROPN
admet-737	128	2	,	,	PUNCT
admet-737	128	3	f.	f.	PROPN
admet-737	128	4	tillier	tillier	PROPN
admet-737	128	5	,	,	PUNCT
admet-737	128	6	r.	r.	PROPN
admet-737	128	7	wyler	wyler	PROPN
admet-737	128	8	,	,	PUNCT
admet-737	128	9	c.	c.	PROPN
admet-737	128	10	lerner	lerner	PROPN
admet-737	128	11	,	,	PUNCT
admet-737	128	12	c.	c.	PROPN
admet-737	128	13	kramer	kramer	PROPN
admet-737	128	14	,	,	PUNCT
admet-737	128	15	h.	h.	PROPN
admet-737	128	16	richter	richter	PROPN
admet-737	128	17	,	,	PUNCT
admet-737	128	18	s.	s.	PROPN
admet-737	128	19	roberts	roberts	PROPN
admet-737	128	20	.	.	PUNCT
admet-737	129	1	safety	safety	NOUN
admet-737	129	2	screening	screen	VERB
admet-737	129	3	in	in	ADP
admet-737	129	4	early	early	ADJ
admet-737	129	5	drug	drug	NOUN
admet-737	129	6	discovery	discovery	NOUN
admet-737	129	7	:	:	PUNCT
admet-737	129	8	an	an	DET
admet-737	129	9	optimized	optimize	VERB
admet-737	129	10	assay	assay	PROPN
admet-737	129	11	panel	panel	NOUN
admet-737	129	12	.	.	PUNCT
admet-737	130	1	journal	journal	PROPN
admet-737	130	2	of	of	ADP
admet-737	130	3	pharmacological	pharmacological	ADJ
admet-737	130	4	and	and	CCONJ
admet-737	130	5	toxicological	toxicological	ADJ
admet-737	130	6	methods	method	NOUN
admet-737	130	7	99	99	NUM
admet-737	130	8	(	(	PUNCT
admet-737	130	9	2019	2019	NUM
admet-737	130	10	)	)	PUNCT
admet-737	130	11	106609	106609	NUM
admet-737	130	12	.	.	PUNCT
admet-737	131	1	admet	admet	PROPN
admet-737	131	2	&	&	CCONJ
admet-737	131	3	dmpk	dmpk	PROPN
admet-737	131	4	7(4	7(4	NUM
admet-737	131	5	)	)	PUNCT
admet-737	131	6	(	(	PUNCT
admet-737	131	7	2019	2019	NUM
admet-737	131	8	)	)	PUNCT
admet-737	131	9	242	242	NUM
admet-737	131	10	-	-	SYM
admet-737	131	11	251	251	NUM
admet-737	131	12	nmr	nmr	NOUN
admet-737	131	13	spectroscopy	spectroscopy	NOUN
admet-737	131	14	in	in	ADP
admet-737	131	15	drug	drug	NOUN
admet-737	131	16	discovery	discovery	NOUN
admet-737	131	17	and	and	CCONJ
admet-737	131	18	development	development	NOUN
admet-737	131	19	doi	doi	PROPN
admet-737	131	20	:	:	PUNCT
admet-737	131	21	10.5599	10.5599	NUM
admet-737	131	22	/	/	SYM
admet-737	131	23	admet.737	admet.737	PROPN
admet-737	131	24	249	249	NUM
admet-737	132	1	[	[	X
admet-737	132	2	4	4	NUM
admet-737	132	3	]	]	X
admet-737	132	4	m.j	m.j	PROPN
admet-737	132	5	.	.	PROPN
admet-737	132	6	waring	waring	PROPN
admet-737	132	7	,	,	PUNCT
admet-737	132	8	j.	j.	PROPN
admet-737	132	9	arrowsmith	arrowsmith	PROPN
admet-737	132	10	,	,	PUNCT
admet-737	132	11	a.r	a.r	PROPN
admet-737	132	12	.	.	PROPN
admet-737	132	13	leach	leach	NOUN
admet-737	132	14	,	,	PUNCT
admet-737	132	15	p.d	p.d	PROPN
admet-737	132	16	.	.	PROPN
admet-737	132	17	leeson	leeson	PROPN
admet-737	132	18	,	,	PUNCT
admet-737	132	19	s.	s.	PROPN
admet-737	132	20	mandrell	mandrell	PROPN
admet-737	132	21	,	,	PUNCT
admet-737	132	22	r.m	r.m	PROPN
admet-737	132	23	.	.	PROPN
admet-737	132	24	owen	owen	PROPN
admet-737	132	25	,	,	PUNCT
admet-737	132	26	g.	g.	PROPN
admet-737	132	27	pairaudeau	pairaudeau	PROPN
admet-737	132	28	,	,	PUNCT
admet-737	132	29	w.d	w.d	PROPN
admet-737	132	30	.	.	PROPN
admet-737	132	31	pennie	pennie	PROPN
admet-737	132	32	,	,	PUNCT
admet-737	132	33	s.d	s.d	PROPN
admet-737	132	34	.	.	PROPN
admet-737	132	35	pickett	pickett	PROPN
admet-737	132	36	,	,	PUNCT
admet-737	132	37	j.	j.	PROPN
admet-737	132	38	wang	wang	PROPN
admet-737	132	39	,	,	PUNCT
admet-737	132	40	o.	o.	PROPN
admet-737	132	41	wallace	wallace	PROPN
admet-737	132	42	,	,	PUNCT
admet-737	132	43	a.	a.	PROPN
admet-737	132	44	weir	weir	PROPN
admet-737	132	45	.	.	PUNCT
admet-737	133	1	an	an	DET
admet-737	133	2	analysis	analysis	NOUN
admet-737	133	3	of	of	ADP
admet-737	133	4	the	the	DET
admet-737	133	5	attrition	attrition	NOUN
admet-737	133	6	of	of	ADP
admet-737	133	7	drug	drug	NOUN
admet-737	133	8	candidates	candidate	NOUN
admet-737	133	9	from	from	ADP
admet-737	133	10	four	four	NUM
admet-737	133	11	major	major	ADJ
admet-737	133	12	pharmaceutical	pharmaceutical	ADJ
admet-737	133	13	companies	company	NOUN
admet-737	133	14	.	.	PUNCT
admet-737	134	1	nat	nat	PROPN
admet-737	134	2	rev	rev	PROPN
admet-737	134	3	drug	drug	PROPN
admet-737	134	4	discov	discov	PROPN
admet-737	134	5	14	14	NUM
admet-737	134	6	(	(	PUNCT
admet-737	134	7	2015	2015	NUM
admet-737	134	8	)	)	PUNCT
admet-737	134	9	475	475	NUM
admet-737	134	10	-	-	SYM
admet-737	134	11	486	486	NUM
admet-737	134	12	.	.	PUNCT
admet-737	135	1	[	[	X
admet-737	135	2	5	5	NUM
admet-737	135	3	]	]	X
admet-737	135	4	l.l	l.l	PROPN
admet-737	135	5	.	.	PROPN
admet-737	135	6	ferreira	ferreira	PROPN
admet-737	135	7	,	,	PUNCT
admet-737	135	8	a.d	a.d	PROPN
admet-737	135	9	.	.	PROPN
admet-737	135	10	andricopulo	andricopulo	PROPN
admet-737	135	11	.	.	PUNCT
admet-737	136	1	admet	admet	PROPN
admet-737	136	2	modeling	model	VERB
admet-737	136	3	approaches	approach	NOUN
admet-737	136	4	in	in	ADP
admet-737	136	5	drug	drug	NOUN
admet-737	136	6	discovery	discovery	NOUN
admet-737	136	7	.	.	PUNCT
admet-737	137	1	drug	drug	NOUN
admet-737	137	2	discovery	discovery	PROPN
admet-737	137	3	today	today	NOUN
admet-737	137	4	24	24	NUM
admet-737	137	5	(	(	PUNCT
admet-737	137	6	2019	2019	NUM
admet-737	137	7	)	)	PUNCT
admet-737	137	8	1157	1157	NUM
admet-737	137	9	-	-	SYM
admet-737	137	10	1165	1165	NUM
admet-737	137	11	.	.	PUNCT
admet-737	138	1	[	[	X
admet-737	138	2	6	6	NUM
admet-737	138	3	]	]	X
admet-737	138	4	t.d	t.d	PROPN
admet-737	138	5	.	.	PROPN
admet-737	138	6	chung	chung	PROPN
admet-737	138	7	,	,	PUNCT
admet-737	138	8	d.b	d.b	PROPN
admet-737	138	9	.	.	PROPN
admet-737	138	10	terry	terry	PROPN
admet-737	138	11	,	,	PUNCT
admet-737	138	12	l.h	l.h	PROPN
admet-737	138	13	.	.	PROPN
admet-737	138	14	smith	smith	PROPN
admet-737	138	15	,	,	PUNCT
admet-737	138	16	in	in	ADP
admet-737	138	17	vitro	vitro	X
admet-737	138	18	and	and	CCONJ
admet-737	138	19	in	in	ADP
admet-737	138	20	vivo	vivo	ADJ
admet-737	138	21	assessment	assessment	NOUN
admet-737	138	22	of	of	ADP
admet-737	138	23	adme	adme	NOUN
admet-737	138	24	and	and	CCONJ
admet-737	138	25	pk	pk	NOUN
admet-737	138	26	properties	property	NOUN
admet-737	138	27	during	during	ADP
admet-737	138	28	lead	lead	ADJ
admet-737	138	29	selection	selection	NOUN
admet-737	138	30	and	and	CCONJ
admet-737	138	31	lead	lead	VERB
admet-737	138	32	optimization	optimization	NOUN
admet-737	138	33	–	–	PUNCT
admet-737	138	34	guidelines	guideline	NOUN
admet-737	138	35	,	,	PUNCT
admet-737	138	36	benchmarks	benchmark	NOUN
admet-737	138	37	and	and	CCONJ
admet-737	138	38	rules	rule	NOUN
admet-737	138	39	of	of	ADP
admet-737	138	40	thumb	thumb	NOUN
admet-737	138	41	,	,	PUNCT
admet-737	138	42	assay	assay	NOUN
admet-737	138	43	guidance	guidance	NOUN
admet-737	138	44	manual	manual	NOUN
admet-737	138	45	[	[	X
admet-737	138	46	internet	internet	NOUN
admet-737	138	47	]	]	X
admet-737	138	48	,	,	PUNCT
admet-737	138	49	eli	eli	PROPN
admet-737	138	50	lilly	lilly	PROPN
admet-737	138	51	&	&	CCONJ
admet-737	138	52	company	company	PROPN
admet-737	138	53	and	and	CCONJ
admet-737	138	54	the	the	DET
admet-737	138	55	national	national	ADJ
admet-737	138	56	center	center	NOUN
admet-737	138	57	for	for	ADP
admet-737	138	58	advancing	advance	VERB
admet-737	138	59	translational	translational	ADJ
admet-737	138	60	sciences2015	sciences2015	PROPN
admet-737	138	61	.	.	PUNCT
admet-737	139	1	[	[	X
admet-737	139	2	7	7	X
admet-737	139	3	]	]	PUNCT
admet-737	139	4	s.	s.	PROPN
admet-737	139	5	bunally	bunally	PROPN
admet-737	139	6	,	,	PUNCT
admet-737	139	7	r.j	r.j	PROPN
admet-737	139	8	.	.	PROPN
admet-737	139	9	young	young	PROPN
admet-737	139	10	.	.	PUNCT
admet-737	140	1	the	the	DET
admet-737	140	2	role	role	NOUN
admet-737	140	3	and	and	CCONJ
admet-737	140	4	impact	impact	NOUN
admet-737	140	5	of	of	ADP
admet-737	140	6	high	high	ADJ
admet-737	140	7	throughput	throughput	NOUN
admet-737	140	8	biomimetic	biomimetic	ADJ
admet-737	140	9	measurements	measurement	NOUN
admet-737	140	10	in	in	ADP
admet-737	140	11	drug	drug	NOUN
admet-737	140	12	discovery	discovery	NOUN
admet-737	140	13	.	.	PUNCT
admet-737	141	1	admet	admet	PROPN
admet-737	141	2	and	and	CCONJ
admet-737	141	3	dmpk	dmpk	VERB
admet-737	141	4	6	6	NUM
admet-737	141	5	(	(	PUNCT
admet-737	141	6	2018	2018	NUM
admet-737	141	7	)	)	PUNCT
admet-737	141	8	74	74	NUM
admet-737	141	9	-	-	SYM
admet-737	141	10	84	84	NUM
admet-737	141	11	.	.	PUNCT
admet-737	142	1	[	[	X
admet-737	142	2	8	8	NUM
admet-737	142	3	]	]	X
admet-737	142	4	k.l	k.l	PROPN
admet-737	142	5	.	.	PROPN
admet-737	142	6	valkó	valkó	PROPN
admet-737	142	7	.	.	PUNCT
admet-737	143	1	lipophilicity	lipophilicity	NOUN
admet-737	143	2	and	and	CCONJ
admet-737	143	3	biomimetic	biomimetic	ADJ
admet-737	143	4	properties	property	NOUN
admet-737	143	5	measured	measure	VERB
admet-737	143	6	by	by	ADP
admet-737	143	7	hplc	hplc	NOUN
admet-737	143	8	to	to	PART
admet-737	143	9	support	support	VERB
admet-737	143	10	drug	drug	NOUN
admet-737	143	11	discovery	discovery	NOUN
admet-737	143	12	.	.	PUNCT
admet-737	144	1	journal	journal	PROPN
admet-737	144	2	of	of	ADP
admet-737	144	3	pharmaceutical	pharmaceutical	NOUN
admet-737	144	4	and	and	CCONJ
admet-737	144	5	biomedical	biomedical	ADJ
admet-737	144	6	analysis	analysis	NOUN
admet-737	144	7	130	130	NUM
admet-737	144	8	(	(	PUNCT
admet-737	144	9	2016	2016	NUM
admet-737	144	10	)	)	PUNCT
admet-737	144	11	35	35	NUM
admet-737	144	12	-	-	SYM
admet-737	144	13	54	54	NUM
admet-737	144	14	.	.	PUNCT
admet-737	145	1	[	[	X
admet-737	145	2	9	9	NUM
admet-737	145	3	]	]	X
admet-737	145	4	g.h	g.h	PROPN
admet-737	145	5	.	.	PUNCT
admet-737	145	6	goetz	goetz	PROPN
admet-737	145	7	,	,	PUNCT
admet-737	145	8	m.	m.	NOUN
admet-737	145	9	shalaeva	shalaeva	NOUN
admet-737	145	10	.	.	PUNCT
admet-737	146	1	leveraging	leverage	VERB
admet-737	146	2	chromatography	chromatography	NOUN
admet-737	146	3	based	base	VERB
admet-737	146	4	physicochemical	physicochemical	ADJ
admet-737	146	5	properties	property	NOUN
admet-737	146	6	for	for	ADP
admet-737	146	7	efficient	efficient	ADJ
admet-737	146	8	drug	drug	NOUN
admet-737	146	9	design	design	NOUN
admet-737	146	10	.	.	PUNCT
admet-737	147	1	admet	admet	PROPN
admet-737	147	2	and	and	CCONJ
admet-737	147	3	dmpk	dmpk	VERB
admet-737	147	4	6	6	NUM
admet-737	147	5	(	(	PUNCT
admet-737	147	6	2018	2018	NUM
admet-737	147	7	)	)	PUNCT
admet-737	147	8	85	85	NUM
admet-737	147	9	-	-	SYM
admet-737	147	10	104	104	NUM
admet-737	147	11	.	.	PUNCT
admet-737	148	1	[	[	X
admet-737	148	2	10	10	NUM
admet-737	148	3	]	]	X
admet-737	148	4	w.	w.	PROPN
admet-737	148	5	jahnke	jahnke	PROPN
admet-737	148	6	.	.	PUNCT
admet-737	149	1	perspectives	perspective	NOUN
admet-737	149	2	of	of	ADP
admet-737	149	3	biomolecular	biomolecular	ADJ
admet-737	149	4	nmr	nmr	NOUN
admet-737	149	5	in	in	ADP
admet-737	149	6	drug	drug	NOUN
admet-737	149	7	discovery	discovery	NOUN
admet-737	149	8	:	:	PUNCT
admet-737	149	9	the	the	DET
admet-737	149	10	blessing	blessing	NOUN
admet-737	149	11	and	and	CCONJ
admet-737	149	12	curse	curse	NOUN
admet-737	149	13	of	of	ADP
admet-737	149	14	versatility	versatility	NOUN
admet-737	149	15	.	.	PUNCT
admet-737	150	1	journal	journal	PROPN
admet-737	150	2	of	of	ADP
admet-737	150	3	biomolecular	biomolecular	ADJ
admet-737	150	4	nmr	nmr	NOUN
admet-737	150	5	39	39	NUM
admet-737	150	6	(	(	PUNCT
admet-737	150	7	2007	2007	NUM
admet-737	150	8	)	)	PUNCT
admet-737	150	9	87	87	NUM
admet-737	150	10	-	-	SYM
admet-737	150	11	90	90	NUM
admet-737	150	12	.	.	PUNCT
admet-737	151	1	[	[	X
admet-737	151	2	11	11	NUM
admet-737	151	3	]	]	PUNCT
admet-737	151	4	d.	d.	PROPN
admet-737	151	5	wishart	wishart	PROPN
admet-737	151	6	.	.	PUNCT
admet-737	152	1	nmr	nmr	NOUN
admet-737	152	2	spectroscopy	spectroscopy	NOUN
admet-737	152	3	and	and	CCONJ
admet-737	152	4	protein	protein	NOUN
admet-737	152	5	structure	structure	NOUN
admet-737	152	6	determination	determination	NOUN
admet-737	152	7	:	:	PUNCT
admet-737	152	8	applications	application	NOUN
admet-737	152	9	to	to	ADP
admet-737	152	10	drug	drug	NOUN
admet-737	152	11	discovery	discovery	NOUN
admet-737	152	12	and	and	CCONJ
admet-737	152	13	development	development	NOUN
admet-737	152	14	.	.	PUNCT
admet-737	153	1	current	current	ADJ
admet-737	153	2	pharmaceutical	pharmaceutical	NOUN
admet-737	153	3	biotechnology	biotechnology	NOUN
admet-737	153	4	6	6	NUM
admet-737	153	5	(	(	PUNCT
admet-737	153	6	2005	2005	NUM
admet-737	153	7	)	)	PUNCT
admet-737	153	8	105	105	NUM
admet-737	153	9	-	-	SYM
admet-737	153	10	120	120	NUM
admet-737	153	11	.	.	PUNCT
admet-737	154	1	[	[	X
admet-737	154	2	12	12	NUM
admet-737	154	3	]	]	X
admet-737	154	4	y.	y.	PROPN
admet-737	154	5	miao	miao	PROPN
admet-737	154	6	,	,	PUNCT
admet-737	154	7	h.	h.	PROPN
admet-737	154	8	qin	qin	PROPN
admet-737	154	9	,	,	PUNCT
admet-737	154	10	r.	r.	PROPN
admet-737	154	11	fu	fu	PROPN
admet-737	154	12	,	,	PUNCT
admet-737	154	13	m.	m.	NOUN
admet-737	154	14	sharma	sharma	PROPN
admet-737	154	15	,	,	PUNCT
admet-737	154	16	t.v	t.v	PROPN
admet-737	154	17	.	.	PROPN
admet-737	154	18	can	can	AUX
admet-737	154	19	,	,	PUNCT
admet-737	154	20	i.	i.	PROPN
admet-737	154	21	hung	hung	PROPN
admet-737	154	22	,	,	PUNCT
admet-737	154	23	s.	s.	PROPN
admet-737	154	24	luca	luca	PROPN
admet-737	154	25	,	,	PUNCT
admet-737	154	26	p.l	p.l	PROPN
admet-737	154	27	.	.	PROPN
admet-737	154	28	gor'kov	gor'kov	PROPN
admet-737	154	29	,	,	PUNCT
admet-737	154	30	w.w	w.w	PROPN
admet-737	154	31	.	.	PROPN
admet-737	154	32	brey	brey	PROPN
admet-737	154	33	,	,	PUNCT
admet-737	154	34	t.a	t.a	PROPN
admet-737	154	35	.	.	PROPN
admet-737	154	36	cross	cross	PROPN
admet-737	154	37	.	.	PUNCT
admet-737	155	1	m2	m2	PROPN
admet-737	155	2	proton	proton	PROPN
admet-737	155	3	channel	channel	NOUN
admet-737	155	4	structural	structural	ADJ
admet-737	155	5	validation	validation	NOUN
admet-737	155	6	from	from	ADP
admet-737	155	7	full	full	ADJ
admet-737	155	8	-	-	PUNCT
admet-737	155	9	length	length	NOUN
admet-737	155	10	protein	protein	NOUN
admet-737	155	11	samples	sample	NOUN
admet-737	155	12	in	in	ADP
admet-737	155	13	synthetic	synthetic	ADJ
admet-737	155	14	bilayers	bilayer	NOUN
admet-737	155	15	and	and	CCONJ
admet-737	155	16	e.	e.	PROPN
admet-737	155	17	coli	coli	NOUN
admet-737	155	18	membranes	membrane	NOUN
admet-737	155	19	.	.	PUNCT
admet-737	156	1	angewandte	angewandte	PROPN
admet-737	156	2	chemie	chemie	PROPN
admet-737	156	3	international	international	PROPN
admet-737	156	4	edition	edition	PROPN
admet-737	156	5	51	51	NUM
admet-737	156	6	(	(	PUNCT
admet-737	156	7	2012	2012	NUM
admet-737	156	8	)	)	PUNCT
admet-737	156	9	8383	8383	NUM
admet-737	156	10	-	-	SYM
admet-737	156	11	8386	8386	NUM
admet-737	156	12	.	.	PUNCT
admet-737	157	1	[	[	X
admet-737	157	2	13	13	NUM
admet-737	157	3	]	]	PUNCT
admet-737	157	4	t.	t.	PROPN
admet-737	157	5	sugiki	sugiki	PROPN
admet-737	157	6	,	,	PUNCT
admet-737	157	7	k.	k.	PROPN
admet-737	157	8	furuita	furuita	PROPN
admet-737	157	9	,	,	PUNCT
admet-737	157	10	t.	t.	NOUN
admet-737	157	11	fujiwara	fujiwara	PROPN
admet-737	157	12	,	,	PUNCT
admet-737	157	13	c.	c.	PROPN
admet-737	157	14	kojima	kojima	PROPN
admet-737	157	15	.	.	PUNCT
admet-737	158	1	current	current	ADJ
admet-737	158	2	nmr	nmr	NOUN
admet-737	158	3	techniques	technique	NOUN
admet-737	158	4	for	for	ADP
admet-737	158	5	structure	structure	NOUN
admet-737	158	6	-	-	PUNCT
admet-737	158	7	based	base	VERB
admet-737	158	8	drug	drug	NOUN
admet-737	158	9	discovery	discovery	NOUN
admet-737	158	10	.	.	PUNCT
admet-737	159	1	molecules	molecule	NOUN
admet-737	159	2	23	23	NUM
admet-737	159	3	(	(	PUNCT
admet-737	159	4	2018	2018	NUM
admet-737	159	5	)	)	PUNCT
admet-737	160	1	e148	e148	NOUN
admet-737	160	2	.	.	PUNCT
admet-737	161	1	[	[	X
admet-737	161	2	14	14	NUM
admet-737	161	3	]	]	X
admet-737	161	4	y.	y.	PROPN
admet-737	161	5	li	li	PROPN
admet-737	161	6	,	,	PUNCT
admet-737	161	7	c.	c.	PROPN
admet-737	161	8	kang	kang	PROPN
admet-737	161	9	.	.	PUNCT
admet-737	162	1	solution	solution	NOUN
admet-737	162	2	nmr	nmr	NOUN
admet-737	162	3	spectroscopy	spectroscopy	VERB
admet-737	162	4	in	in	ADP
admet-737	162	5	target	target	NOUN
admet-737	162	6	-	-	PUNCT
admet-737	162	7	based	base	VERB
admet-737	162	8	drug	drug	NOUN
admet-737	162	9	discovery	discovery	NOUN
admet-737	162	10	.	.	PUNCT
admet-737	163	1	molecules	molecule	NOUN
admet-737	163	2	22	22	NUM
admet-737	163	3	(	(	PUNCT
admet-737	163	4	2017	2017	NUM
admet-737	163	5	)	)	PUNCT
admet-737	163	6	e1399	e1399	NOUN
admet-737	163	7	.	.	PUNCT
admet-737	164	1	[	[	X
admet-737	164	2	15	15	NUM
admet-737	164	3	]	]	X
admet-737	164	4	c.	c.	PROPN
admet-737	164	5	kang	kang	PROPN
admet-737	164	6	.	.	PUNCT
admet-737	165	1	applications	application	NOUN
admet-737	165	2	of	of	ADP
admet-737	165	3	in	in	ADP
admet-737	165	4	-	-	PUNCT
admet-737	165	5	cell	cell	NOUN
admet-737	165	6	nmr	nmr	NOUN
admet-737	165	7	in	in	ADP
admet-737	165	8	structural	structural	ADJ
admet-737	165	9	biology	biology	NOUN
admet-737	165	10	and	and	CCONJ
admet-737	165	11	drug	drug	NOUN
admet-737	165	12	discovery	discovery	NOUN
admet-737	165	13	.	.	PUNCT
admet-737	166	1	international	international	ADJ
admet-737	166	2	journal	journal	NOUN
admet-737	166	3	of	of	ADP
admet-737	166	4	molecular	molecular	ADJ
admet-737	166	5	sciences	science	NOUN
admet-737	166	6	20	20	NUM
admet-737	166	7	(	(	PUNCT
admet-737	166	8	2019	2019	NUM
admet-737	166	9	)	)	PUNCT
admet-737	166	10	e139	e139	PROPN
admet-737	166	11	.	.	PUNCT
admet-737	167	1	[	[	X
admet-737	167	2	16	16	NUM
admet-737	167	3	]	]	X
admet-737	167	4	a.d	a.d	PROPN
admet-737	167	5	.	.	PROPN
admet-737	167	6	gossert	gossert	PROPN
admet-737	167	7	,	,	PUNCT
admet-737	167	8	w.	w.	PROPN
admet-737	167	9	jahnke	jahnke	PROPN
admet-737	167	10	.	.	PUNCT
admet-737	168	1	nmr	nmr	NOUN
admet-737	168	2	in	in	ADP
admet-737	168	3	drug	drug	NOUN
admet-737	168	4	discovery	discovery	NOUN
admet-737	168	5	:	:	PUNCT
admet-737	168	6	a	a	DET
admet-737	168	7	practical	practical	ADJ
admet-737	168	8	guide	guide	NOUN
admet-737	168	9	to	to	ADP
admet-737	168	10	identification	identification	NOUN
admet-737	168	11	and	and	CCONJ
admet-737	168	12	validation	validation	NOUN
admet-737	168	13	of	of	ADP
admet-737	168	14	ligands	ligand	NOUN
admet-737	168	15	interacting	interact	VERB
admet-737	168	16	with	with	ADP
admet-737	168	17	biological	biological	ADJ
admet-737	168	18	macromolecules	macromolecule	NOUN
admet-737	168	19	.	.	PUNCT
admet-737	169	1	progress	progress	NOUN
admet-737	169	2	in	in	ADP
admet-737	169	3	nuclear	nuclear	ADJ
admet-737	169	4	magnetic	magnetic	ADJ
admet-737	169	5	resonance	resonance	NOUN
admet-737	169	6	spectroscopy	spectroscopy	VERB
admet-737	169	7	97	97	NUM
admet-737	169	8	(	(	PUNCT
admet-737	169	9	2016	2016	NUM
admet-737	169	10	)	)	PUNCT
admet-737	169	11	82	82	NUM
admet-737	169	12	-	-	SYM
admet-737	169	13	125	125	NUM
admet-737	169	14	.	.	PUNCT
admet-737	170	1	[	[	X
admet-737	170	2	17	17	NUM
admet-737	170	3	]	]	X
admet-737	170	4	e.	e.	PROPN
admet-737	170	5	chiarparin	chiarparin	PROPN
admet-737	170	6	,	,	PUNCT
admet-737	170	7	m.j	m.j	PROPN
admet-737	170	8	.	.	PROPN
admet-737	170	9	packer	packer	PROPN
admet-737	170	10	,	,	PUNCT
admet-737	170	11	d.m	d.m	PROPN
admet-737	170	12	.	.	PROPN
admet-737	170	13	wilson	wilson	PROPN
admet-737	170	14	.	.	PUNCT
admet-737	171	1	experimental	experimental	ADJ
admet-737	171	2	free	free	ADJ
admet-737	171	3	ligand	ligand	PROPN
admet-737	171	4	conformations	conformation	NOUN
admet-737	171	5	:	:	PUNCT
admet-737	171	6	a	a	DET
admet-737	171	7	missing	miss	VERB
admet-737	171	8	link	link	NOUN
admet-737	171	9	in	in	ADP
admet-737	171	10	structure	structure	NOUN
admet-737	171	11	-	-	PUNCT
admet-737	171	12	based	base	VERB
admet-737	171	13	drug	drug	NOUN
admet-737	171	14	discovery	discovery	NOUN
admet-737	171	15	.	.	PUNCT
admet-737	172	1	future	future	ADJ
admet-737	172	2	science	science	NOUN
admet-737	172	3	,	,	PUNCT
admet-737	172	4	2019	2019	NUM
admet-737	172	5	,	,	PUNCT
admet-737	172	6	pp	pp	ADJ
admet-737	172	7	.	.	PUNCT
admet-737	173	1	79	79	NUM
admet-737	173	2	-	-	SYM
admet-737	173	3	82	82	NUM
admet-737	173	4	.	.	PUNCT
admet-737	174	1	[	[	X
admet-737	174	2	18	18	NUM
admet-737	174	3	]	]	PUNCT
admet-737	174	4	a.	a.	NOUN
admet-737	174	5	pandya	pandya	PROPN
admet-737	174	6	,	,	PUNCT
admet-737	174	7	m.j	m.j	PROPN
admet-737	174	8	.	.	PROPN
admet-737	174	9	howard	howard	PROPN
admet-737	174	10	,	,	PUNCT
admet-737	174	11	m.	m.	NOUN
admet-737	174	12	zloh	zloh	PROPN
admet-737	174	13	,	,	PUNCT
admet-737	174	14	p.a	p.a	PROPN
admet-737	174	15	.	.	PUNCT
admet-737	174	16	dalby	dalby	PROPN
admet-737	174	17	.	.	PUNCT
admet-737	175	1	an	an	DET
admet-737	175	2	evaluation	evaluation	NOUN
admet-737	175	3	of	of	ADP
admet-737	175	4	the	the	DET
admet-737	175	5	potential	potential	NOUN
admet-737	175	6	of	of	ADP
admet-737	175	7	nmr	nmr	NOUN
admet-737	175	8	spectroscopy	spectroscopy	NOUN
admet-737	175	9	and	and	CCONJ
admet-737	175	10	computational	computational	ADJ
admet-737	175	11	modelling	modelling	NOUN
admet-737	175	12	methods	method	NOUN
admet-737	175	13	to	to	PART
admet-737	175	14	inform	inform	VERB
admet-737	175	15	biopharmaceutical	biopharmaceutical	ADJ
admet-737	175	16	formulations	formulation	NOUN
admet-737	175	17	.	.	PUNCT
admet-737	176	1	pharmaceutics	pharmaceutic	NOUN
admet-737	176	2	10	10	NUM
admet-737	176	3	(	(	PUNCT
admet-737	176	4	2018	2018	NUM
admet-737	176	5	)	)	PUNCT
admet-737	176	6	e165	e165	NUM
admet-737	176	7	.	.	PUNCT
admet-737	177	1	[	[	X
admet-737	177	2	19	19	NUM
admet-737	177	3	]	]	PUNCT
admet-737	177	4	a.	a.	NOUN
admet-737	177	5	vignoli	vignoli	NOUN
admet-737	177	6	,	,	PUNCT
admet-737	177	7	v.	v.	CCONJ
admet-737	177	8	ghini	ghini	PROPN
admet-737	177	9	,	,	PUNCT
admet-737	177	10	g.	g.	PROPN
admet-737	177	11	meoni	meoni	PROPN
admet-737	177	12	,	,	PUNCT
admet-737	177	13	c.	c.	PROPN
admet-737	177	14	licari	licari	PROPN
admet-737	177	15	,	,	PUNCT
admet-737	177	16	p.g	p.g	PROPN
admet-737	177	17	.	.	PROPN
admet-737	177	18	takis	takis	PROPN
admet-737	177	19	,	,	PUNCT
admet-737	177	20	l.	l.	PROPN
admet-737	177	21	tenori	tenori	PROPN
admet-737	177	22	,	,	PUNCT
admet-737	177	23	p.	p.	NOUN
admet-737	177	24	turano	turano	NOUN
admet-737	177	25	,	,	PUNCT
admet-737	177	26	c.	c.	PROPN
admet-737	177	27	luchinat	luchinat	PROPN
admet-737	177	28	.	.	PUNCT
admet-737	178	1	high‐throughput	high‐throughput	VERB
admet-737	178	2	metabolomics	metabolomic	NOUN
admet-737	178	3	by	by	ADP
admet-737	178	4	1d	1d	NUM
admet-737	178	5	nmr	nmr	NOUN
admet-737	178	6	.	.	PUNCT
admet-737	179	1	angewandte	angewandte	PROPN
admet-737	179	2	chemie	chemie	PROPN
admet-737	179	3	international	international	PROPN
admet-737	179	4	edition	edition	PROPN
admet-737	179	5	58	58	NUM
admet-737	179	6	(	(	PUNCT
admet-737	179	7	2019	2019	NUM
admet-737	179	8	)	)	PUNCT
admet-737	179	9	968	968	NUM
admet-737	179	10	-	-	SYM
admet-737	179	11	994	994	NUM
admet-737	179	12	.	.	PUNCT
admet-737	180	1	[	[	X
admet-737	180	2	20	20	NUM
admet-737	180	3	]	]	PUNCT
admet-737	180	4	a.	a.	NOUN
admet-737	180	5	guleria	guleria	PROPN
admet-737	180	6	,	,	PUNCT
admet-737	180	7	a.	a.	PROPN
admet-737	180	8	kumar	kumar	PROPN
admet-737	180	9	,	,	PUNCT
admet-737	180	10	u.	u.	PROPN
admet-737	180	11	kumar	kumar	PROPN
admet-737	180	12	,	,	PUNCT
admet-737	180	13	r.	r.	PROPN
admet-737	180	14	raj	raj	PROPN
admet-737	180	15	,	,	PUNCT
admet-737	180	16	d.	d.	PROPN
admet-737	180	17	kumar	kumar	PROPN
admet-737	180	18	.	.	PROPN
admet-737	181	1	nmr	nmr	NOUN
admet-737	181	2	based	base	VERB
admet-737	181	3	metabolomics	metabolomic	NOUN
admet-737	181	4	:	:	PUNCT
admet-737	181	5	an	an	DET
admet-737	181	6	exquisite	exquisite	ADJ
admet-737	181	7	and	and	CCONJ
admet-737	181	8	facile	facile	ADJ
admet-737	181	9	method	method	NOUN
admet-737	181	10	for	for	ADP
admet-737	181	11	evaluating	evaluate	VERB
admet-737	181	12	therapeutic	therapeutic	ADJ
admet-737	181	13	efficacy	efficacy	NOUN
admet-737	181	14	and	and	CCONJ
admet-737	181	15	screening	screen	VERB
admet-737	181	16	drug	drug	NOUN
admet-737	181	17	toxicity	toxicity	NOUN
admet-737	181	18	.	.	PUNCT
admet-737	182	1	current	current	ADJ
admet-737	182	2	topics	topic	NOUN
admet-737	182	3	in	in	ADP
admet-737	182	4	medicinal	medicinal	ADJ
admet-737	182	5	chemistry	chemistry	NOUN
admet-737	182	6	18	18	NUM
admet-737	182	7	(	(	PUNCT
admet-737	182	8	2018	2018	NUM
admet-737	182	9	)	)	PUNCT
admet-737	182	10	1827	1827	NUM
admet-737	182	11	-	-	SYM
admet-737	182	12	1849	1849	NUM
admet-737	182	13	.	.	PUNCT
admet-737	183	1	[	[	X
admet-737	183	2	21	21	NUM
admet-737	183	3	]	]	X
admet-737	183	4	p.	p.	NOUN
admet-737	183	5	keizers	keizer	NOUN
admet-737	183	6	,	,	PUNCT
admet-737	183	7	a.	a.	PROPN
admet-737	183	8	van	van	PROPN
admet-737	183	9	drongelen	drongelen	PROPN
admet-737	183	10	,	,	PUNCT
admet-737	183	11	w.	w.	PROPN
admet-737	183	12	de	de	PROPN
admet-737	183	13	jong	jong	PROPN
admet-737	183	14	,	,	PUNCT
admet-737	183	15	c.	c.	PROPN
admet-737	183	16	van	van	PROPN
admet-737	183	17	oostrom	oostrom	PROPN
admet-737	183	18	,	,	PUNCT
admet-737	183	19	b.	b.	PROPN
admet-737	183	20	roszek	roszek	PROPN
admet-737	183	21	,	,	PUNCT
admet-737	183	22	b.	b.	PROPN
admet-737	183	23	venhuis	venhuis	PROPN
admet-737	183	24	,	,	PUNCT
admet-737	183	25	c.	c.	PROPN
admet-737	183	26	de	de	PROPN
admet-737	183	27	vries	vries	PROPN
admet-737	183	28	,	,	PUNCT
admet-737	183	29	r.	r.	PROPN
admet-737	183	30	geertsma	geertsma	PROPN
admet-737	183	31	,	,	PUNCT
admet-737	183	32	r.	r.	PROPN
admet-737	183	33	janssen	janssen	PROPN
admet-737	183	34	.	.	PUNCT
admet-737	184	1	silicone	silicone	NOUN
admet-737	184	2	breast	breast	NOUN
admet-737	184	3	implants	implant	NOUN
admet-737	184	4	in	in	ADP
admet-737	184	5	the	the	DET
admet-737	184	6	netherlands	netherlands	PROPN
admet-737	184	7	:	:	PUNCT
admet-737	184	8	a	a	DET
admet-737	184	9	market	market	NOUN
admet-737	184	10	surveillance	surveillance	NOUN
admet-737	184	11	study	study	NOUN
admet-737	184	12	.	.	PUNCT
admet-737	185	1	(	(	PUNCT
admet-737	185	2	2016	2016	NUM
admet-737	185	3	)	)	PUNCT
admet-737	185	4	.	.	PUNCT
admet-737	186	1	[	[	X
admet-737	186	2	22	22	NUM
admet-737	186	3	]	]	PUNCT
admet-737	186	4	p.-c	p.-c	NOUN
admet-737	186	5	.	.	PUNCT
admet-737	187	1	wu	wu	PROPN
admet-737	187	2	,	,	PUNCT
admet-737	187	3	y.-c	y.-c	PROPN
admet-737	187	4	.	.	PUNCT
admet-737	188	1	yang	yang	PROPN
admet-737	188	2	,	,	PUNCT
admet-737	188	3	d.-y	d.-y	PROPN
admet-737	188	4	.	.	PUNCT
admet-737	189	1	wang	wang	PROPN
admet-737	189	2	,	,	PUNCT
admet-737	189	3	h.-f	h.-f	NOUN
admet-737	189	4	.	.	PUNCT
admet-737	190	1	cheng	cheng	PROPN
admet-737	190	2	.	.	PUNCT
admet-737	191	1	scientific	scientific	ADJ
admet-737	191	2	and	and	CCONJ
admet-737	191	3	regulatory	regulatory	ADJ
admet-737	191	4	perspective	perspective	NOUN
admet-737	191	5	on	on	ADP
admet-737	191	6	monoclonal	monoclonal	NOUN
admet-737	191	7	antibody	antibody	NOUN
admet-737	191	8	biosimilars	biosimilar	VERB
admet-737	191	9	.	.	PUNCT
admet-737	192	1	biopharmaceuticals	biopharmaceutical	NOUN
admet-737	192	2	(	(	PUNCT
admet-737	192	3	2018	2018	NUM
admet-737	192	4	)	)	PUNCT
admet-737	192	5	111	111	NUM
admet-737	192	6	.	.	PUNCT
admet-737	193	1	[	[	X
admet-737	193	2	23	23	NUM
admet-737	193	3	]	]	X
admet-737	193	4	s.k	s.k	PROPN
admet-737	193	5	.	.	PROPN
admet-737	193	6	bharti	bharti	PROPN
admet-737	193	7	,	,	PUNCT
admet-737	193	8	r.	r.	PROPN
admet-737	193	9	roy	roy	PROPN
admet-737	193	10	.	.	PROPN
admet-737	194	1	quantitative	quantitative	ADJ
admet-737	194	2	1h	1h	NUM
admet-737	194	3	nmr	nmr	NOUN
admet-737	194	4	spectroscopy	spectroscopy	NOUN
admet-737	194	5	.	.	PUNCT
admet-737	195	1	trac	trac	NOUN
admet-737	195	2	trends	trend	NOUN
admet-737	195	3	in	in	ADP
admet-737	195	4	analytical	analytical	ADJ
admet-737	195	5	chemistry	chemistry	NOUN
admet-737	195	6	35	35	NUM
admet-737	195	7	(	(	PUNCT
admet-737	195	8	2012	2012	NUM
admet-737	195	9	)	)	PUNCT
admet-737	195	10	5	5	NUM
admet-737	195	11	-	-	SYM
admet-737	195	12	26	26	NUM
admet-737	195	13	.	.	PUNCT
admet-737	196	1	mire	mire	NOUN
admet-737	196	2	zloh	zloh	PROPN
admet-737	196	3	admet	admet	PROPN
admet-737	196	4	&	&	CCONJ
admet-737	196	5	dmpk	dmpk	PROPN
admet-737	196	6	7(4	7(4	NUM
admet-737	196	7	)	)	PUNCT
admet-737	196	8	(	(	PUNCT
admet-737	196	9	2019	2019	NUM
admet-737	196	10	)	)	PUNCT
admet-737	196	11	242	242	NUM
admet-737	196	12	-	-	SYM
admet-737	196	13	251	251	NUM
admet-737	196	14	250	250	NUM
admet-737	197	1	[	[	X
admet-737	197	2	24	24	NUM
admet-737	197	3	]	]	X
admet-737	197	4	g.	g.	PROPN
admet-737	197	5	del	del	PROPN
admet-737	197	6	campo	campo	PROPN
admet-737	197	7	,	,	PUNCT
admet-737	197	8	i.	i.	PROPN
admet-737	197	9	berregi	berregi	PROPN
admet-737	197	10	,	,	PUNCT
admet-737	197	11	r.	r.	PROPN
admet-737	197	12	caracena	caracena	PROPN
admet-737	197	13	,	,	PUNCT
admet-737	197	14	j.	j.	PROPN
admet-737	197	15	zuriarrain	zuriarrain	PROPN
admet-737	197	16	.	.	PUNCT
admet-737	198	1	quantitative	quantitative	ADJ
admet-737	198	2	determination	determination	NOUN
admet-737	198	3	of	of	ADP
admet-737	198	4	caffeine	caffeine	NOUN
admet-737	198	5	,	,	PUNCT
admet-737	198	6	formic	formic	ADJ
admet-737	198	7	acid	acid	NOUN
admet-737	198	8	,	,	PUNCT
admet-737	198	9	trigonelline	trigonelline	NOUN
admet-737	198	10	and	and	CCONJ
admet-737	198	11	5-(hydroxymethyl)furfural	5-(hydroxymethyl)furfural	NUM
admet-737	198	12	in	in	ADP
admet-737	198	13	soluble	soluble	ADJ
admet-737	198	14	coffees	coffee	NOUN
admet-737	198	15	by	by	ADP
admet-737	198	16	1h	1h	NUM
admet-737	198	17	nmr	nmr	NOUN
admet-737	198	18	spectrometry	spectrometry	NOUN
admet-737	198	19	.	.	PUNCT
admet-737	199	1	talanta	talanta	PROPN
admet-737	199	2	81	81	NUM
admet-737	199	3	(	(	PUNCT
admet-737	199	4	2010	2010	NUM
admet-737	199	5	)	)	PUNCT
admet-737	199	6	367	367	NUM
admet-737	199	7	-	-	SYM
admet-737	199	8	371	371	NUM
admet-737	199	9	.	.	PUNCT
admet-737	200	1	[	[	X
admet-737	200	2	25	25	NUM
admet-737	200	3	]	]	PUNCT
admet-737	200	4	a.	a.	NOUN
admet-737	200	5	sahu	sahu	PROPN
admet-737	200	6	,	,	PUNCT
admet-737	200	7	m.	m.	NOUN
admet-737	200	8	narayanam	narayanam	PROPN
admet-737	200	9	,	,	PUNCT
admet-737	200	10	m.	m.	NOUN
admet-737	200	11	kurmi	kurmi	PROPN
admet-737	200	12	,	,	PUNCT
admet-737	200	13	m.k	m.k	PROPN
admet-737	200	14	.	.	PROPN
admet-737	200	15	ladumor	ladumor	PROPN
admet-737	200	16	,	,	PUNCT
admet-737	200	17	s.	s.	PROPN
admet-737	200	18	singh	singh	PROPN
admet-737	200	19	.	.	PUNCT
admet-737	201	1	quantitation	quantitation	NOUN
admet-737	201	2	of	of	ADP
admet-737	201	3	memantine	memantine	ADJ
admet-737	201	4	hydrochloride	hydrochloride	NOUN
admet-737	201	5	bulk	bulk	NOUN
admet-737	201	6	drug	drug	NOUN
admet-737	201	7	and	and	CCONJ
admet-737	201	8	its	its	PRON
admet-737	201	9	tablet	tablet	ADJ
admet-737	201	10	formulation	formulation	NOUN
admet-737	201	11	using	use	VERB
admet-737	201	12	proton	proton	NOUN
admet-737	201	13	nuclear	nuclear	ADJ
admet-737	201	14	magnetic	magnetic	ADJ
admet-737	201	15	resonance	resonance	NOUN
admet-737	201	16	spectrometry	spectrometry	NOUN
admet-737	201	17	.	.	PUNCT
admet-737	202	1	magnetic	magnetic	ADJ
admet-737	202	2	resonance	resonance	NOUN
admet-737	202	3	in	in	ADP
admet-737	202	4	chemistry	chemistry	NOUN
admet-737	202	5	54	54	NUM
admet-737	202	6	(	(	PUNCT
admet-737	202	7	2016	2016	NUM
admet-737	202	8	)	)	PUNCT
admet-737	202	9	632	632	NUM
admet-737	202	10	-	-	SYM
admet-737	202	11	636	636	NUM
admet-737	202	12	.	.	PUNCT
admet-737	203	1	[	[	X
admet-737	203	2	26	26	NUM
admet-737	203	3	]	]	PUNCT
admet-737	203	4	t.	t.	PROPN
admet-737	203	5	rundlöf	rundlöf	PROPN
admet-737	203	6	,	,	PUNCT
admet-737	203	7	m.	m.	NOUN
admet-737	203	8	mathiasson	mathiasson	PROPN
admet-737	203	9	,	,	PUNCT
admet-737	203	10	s.	s.	PROPN
admet-737	203	11	bekiroglu	bekiroglu	PROPN
admet-737	203	12	,	,	PUNCT
admet-737	203	13	b.	b.	PROPN
admet-737	203	14	hakkarainen	hakkarainen	PROPN
admet-737	203	15	,	,	PUNCT
admet-737	203	16	t.	t.	PROPN
admet-737	203	17	bowden	bowden	PROPN
admet-737	203	18	,	,	PUNCT
admet-737	203	19	t.	t.	PROPN
admet-737	203	20	arvidsson	arvidsson	PROPN
admet-737	203	21	.	.	PUNCT
admet-737	204	1	survey	survey	NOUN
admet-737	204	2	and	and	CCONJ
admet-737	204	3	qualification	qualification	NOUN
admet-737	204	4	of	of	ADP
admet-737	204	5	internal	internal	ADJ
admet-737	204	6	standards	standard	NOUN
admet-737	204	7	for	for	ADP
admet-737	204	8	quantification	quantification	NOUN
admet-737	204	9	by	by	ADP
admet-737	204	10	1h	1h	NUM
admet-737	204	11	nmr	nmr	NOUN
admet-737	204	12	spectroscopy	spectroscopy	NOUN
admet-737	204	13	.	.	PUNCT
admet-737	205	1	journal	journal	NOUN
admet-737	205	2	of	of	ADP
admet-737	205	3	pharmaceutical	pharmaceutical	NOUN
admet-737	205	4	and	and	CCONJ
admet-737	205	5	biomedical	biomedical	ADJ
admet-737	205	6	analysis	analysis	NOUN
admet-737	205	7	52	52	NUM
admet-737	205	8	(	(	PUNCT
admet-737	205	9	2010	2010	NUM
admet-737	205	10	)	)	PUNCT
admet-737	205	11	645	645	NUM
admet-737	205	12	-	-	SYM
admet-737	205	13	651	651	NUM
admet-737	205	14	.	.	PUNCT
admet-737	206	1	[	[	X
admet-737	206	2	27	27	NUM
admet-737	206	3	]	]	X
admet-737	206	4	c.	c.	PROPN
admet-737	206	5	sterling	sterling	PROPN
admet-737	206	6	,	,	PUNCT
admet-737	206	7	r.	r.	PROPN
admet-737	206	8	crouch	crouch	PROPN
admet-737	206	9	,	,	PUNCT
admet-737	206	10	d.j	d.j	PROPN
admet-737	206	11	.	.	PROPN
admet-737	206	12	russell	russell	PROPN
admet-737	206	13	,	,	PUNCT
admet-737	206	14	a.i	a.i	PROPN
admet-737	206	15	.	.	PROPN
admet-737	206	16	calderón	calderón	PROPN
admet-737	206	17	.	.	PUNCT
admet-737	207	1	1h‐nmr	1h‐nmr	NUM
admet-737	207	2	quantification	quantification	NOUN
admet-737	207	3	of	of	ADP
admet-737	207	4	major	major	ADJ
admet-737	207	5	saccharides	saccharide	NOUN
admet-737	207	6	in	in	ADP
admet-737	207	7	açaí	açaí	X
admet-737	207	8	raw	raw	ADJ
admet-737	207	9	materials	material	NOUN
admet-737	207	10	:	:	PUNCT
admet-737	207	11	a	a	DET
admet-737	207	12	comparison	comparison	NOUN
admet-737	207	13	of	of	ADP
admet-737	207	14	the	the	DET
admet-737	207	15	internal	internal	ADJ
admet-737	207	16	standard	standard	ADJ
admet-737	207	17	methodology	methodology	NOUN
admet-737	207	18	with	with	ADP
admet-737	207	19	the	the	DET
admet-737	207	20	absolute	absolute	ADJ
admet-737	207	21	intensity	intensity	NOUN
admet-737	207	22	qnmr	qnmr	NOUN
admet-737	207	23	method	method	NOUN
admet-737	207	24	.	.	PUNCT
admet-737	208	1	phytochemical	phytochemical	ADJ
admet-737	208	2	analysis	analysis	NOUN
admet-737	208	3	24	24	NUM
admet-737	208	4	(	(	PUNCT
admet-737	208	5	2013	2013	NUM
admet-737	208	6	)	)	PUNCT
admet-737	208	7	631	631	NUM
admet-737	208	8	-	-	PUNCT
admet-737	208	9	637	637	NUM
admet-737	208	10	.	.	PUNCT
admet-737	209	1	[	[	X
admet-737	209	2	28	28	NUM
admet-737	209	3	]	]	X
admet-737	209	4	y.b	y.b	PROPN
admet-737	209	5	.	.	PROPN
admet-737	209	6	monakhova	monakhova	PROPN
admet-737	209	7	,	,	PUNCT
admet-737	209	8	b.w	b.w	PROPN
admet-737	209	9	.	.	PROPN
admet-737	209	10	diehl	diehl	PROPN
admet-737	209	11	.	.	PROPN
admet-737	210	1	practical	practical	ADJ
admet-737	210	2	guide	guide	NOUN
admet-737	210	3	for	for	ADP
admet-737	210	4	selection	selection	NOUN
admet-737	210	5	of	of	ADP
admet-737	210	6	1h	1h	NUM
admet-737	210	7	qnmr	qnmr	PROPN
admet-737	210	8	acquisition	acquisition	NOUN
admet-737	210	9	and	and	CCONJ
admet-737	210	10	processing	processing	NOUN
admet-737	210	11	parameters	parameter	NOUN
admet-737	210	12	confirmed	confirm	VERB
admet-737	210	13	by	by	ADP
admet-737	210	14	automated	automate	VERB
admet-737	210	15	spectra	spectra	ADJ
admet-737	210	16	evaluation	evaluation	NOUN
admet-737	210	17	.	.	PUNCT
admet-737	211	1	magnetic	magnetic	ADJ
admet-737	211	2	resonance	resonance	NOUN
admet-737	211	3	in	in	ADP
admet-737	211	4	chemistry	chemistry	NOUN
admet-737	211	5	55	55	NUM
admet-737	211	6	(	(	PUNCT
admet-737	211	7	2017	2017	NUM
admet-737	211	8	)	)	PUNCT
admet-737	211	9	996	996	NUM
admet-737	211	10	-	-	SYM
admet-737	211	11	1005	1005	NUM
admet-737	211	12	.	.	PUNCT
admet-737	212	1	[	[	X
admet-737	212	2	29	29	NUM
admet-737	212	3	]	]	X
admet-737	212	4	s.	s.	PROPN
admet-737	212	5	singh	singh	PROPN
admet-737	212	6	,	,	PUNCT
admet-737	212	7	r.	r.	PROPN
admet-737	212	8	roy	roy	PROPN
admet-737	212	9	.	.	PUNCT
admet-737	213	1	the	the	DET
admet-737	213	2	application	application	NOUN
admet-737	213	3	of	of	ADP
admet-737	213	4	absolute	absolute	ADJ
admet-737	213	5	quantitative	quantitative	ADJ
admet-737	213	6	1h	1h	NUM
admet-737	213	7	nmr	nmr	NOUN
admet-737	213	8	spectroscopy	spectroscopy	NOUN
admet-737	213	9	in	in	ADP
admet-737	213	10	drug	drug	NOUN
admet-737	213	11	discovery	discovery	NOUN
admet-737	213	12	and	and	CCONJ
admet-737	213	13	development	development	NOUN
admet-737	213	14	.	.	PUNCT
admet-737	214	1	expert	expert	ADJ
admet-737	214	2	opinion	opinion	NOUN
admet-737	214	3	on	on	ADP
admet-737	214	4	drug	drug	NOUN
admet-737	214	5	discovery	discovery	NOUN
admet-737	214	6	11	11	NUM
admet-737	214	7	(	(	PUNCT
admet-737	214	8	2016	2016	NUM
admet-737	214	9	)	)	PUNCT
admet-737	214	10	695	695	NUM
admet-737	214	11	-	-	SYM
admet-737	214	12	706	706	NUM
admet-737	214	13	.	.	PUNCT
admet-737	215	1	[	[	X
admet-737	215	2	30	30	NUM
admet-737	215	3	]	]	X
admet-737	215	4	f.	f.	PROPN
admet-737	215	5	malz	malz	PROPN
admet-737	215	6	,	,	PUNCT
admet-737	215	7	h.	h.	PROPN
admet-737	215	8	jancke	jancke	PROPN
admet-737	215	9	.	.	PUNCT
admet-737	216	1	validation	validation	NOUN
admet-737	216	2	of	of	ADP
admet-737	216	3	quantitative	quantitative	ADJ
admet-737	216	4	nmr	nmr	NOUN
admet-737	216	5	.	.	PUNCT
admet-737	217	1	journal	journal	PROPN
admet-737	217	2	of	of	ADP
admet-737	217	3	pharmaceutical	pharmaceutical	NOUN
admet-737	217	4	and	and	CCONJ
admet-737	217	5	biomedical	biomedical	ADJ
admet-737	217	6	analysis	analysis	NOUN
admet-737	217	7	38	38	NUM
admet-737	217	8	(	(	PUNCT
admet-737	217	9	2005	2005	NUM
admet-737	217	10	)	)	PUNCT
admet-737	217	11	813	813	NUM
admet-737	217	12	-	-	SYM
admet-737	217	13	823	823	NUM
admet-737	217	14	.	.	PUNCT
admet-737	218	1	[	[	X
admet-737	218	2	31	31	NUM
admet-737	218	3	]	]	X
admet-737	218	4	h.	h.	PROPN
admet-737	218	5	mo	mo	PROPN
admet-737	218	6	,	,	PUNCT
admet-737	218	7	d.	d.	PROPN
admet-737	218	8	raftery	raftery	PROPN
admet-737	218	9	.	.	PUNCT
admet-737	219	1	solvent	solvent	ADJ
admet-737	219	2	signal	signal	NOUN
admet-737	219	3	as	as	ADP
admet-737	219	4	an	an	DET
admet-737	219	5	nmr	nmr	NOUN
admet-737	219	6	concentration	concentration	NOUN
admet-737	219	7	reference	reference	NOUN
admet-737	219	8	.	.	PUNCT
admet-737	220	1	analytical	analytical	ADJ
admet-737	220	2	chemistry	chemistry	NOUN
admet-737	220	3	80	80	NUM
admet-737	220	4	(	(	PUNCT
admet-737	220	5	2008	2008	NUM
admet-737	220	6	)	)	PUNCT
admet-737	220	7	9835	9835	NUM
admet-737	220	8	-	-	SYM
admet-737	220	9	9839	9839	NUM
admet-737	220	10	.	.	PUNCT
admet-737	221	1	[	[	X
admet-737	221	2	32	32	NUM
admet-737	221	3	]	]	PUNCT
admet-737	221	4	m.	m.	NOUN
admet-737	221	5	lin	lin	PROPN
admet-737	221	6	,	,	PUNCT
admet-737	221	7	m.	m.	NOUN
admet-737	221	8	tesconi	tesconi	NOUN
admet-737	221	9	,	,	PUNCT
admet-737	221	10	m.	m.	NOUN
admet-737	221	11	tischler	tischler	NOUN
admet-737	221	12	.	.	PUNCT
admet-737	222	1	use	use	NOUN
admet-737	222	2	of	of	ADP
admet-737	222	3	1h	1h	NUM
admet-737	222	4	nmr	nmr	NOUN
admet-737	222	5	to	to	PART
admet-737	222	6	facilitate	facilitate	VERB
admet-737	222	7	solubility	solubility	NOUN
admet-737	222	8	measurement	measurement	NOUN
admet-737	222	9	for	for	ADP
admet-737	222	10	drug	drug	NOUN
admet-737	222	11	discovery	discovery	NOUN
admet-737	222	12	compounds	compound	NOUN
admet-737	222	13	.	.	PUNCT
admet-737	223	1	international	international	ADJ
admet-737	223	2	journal	journal	PROPN
admet-737	223	3	of	of	ADP
admet-737	223	4	pharmaceutics	pharmaceutic	NOUN
admet-737	223	5	369	369	NUM
admet-737	223	6	(	(	PUNCT
admet-737	223	7	2009	2009	NUM
admet-737	223	8	)	)	PUNCT
admet-737	223	9	47	47	NUM
admet-737	223	10	-	-	SYM
admet-737	223	11	52	52	NUM
admet-737	223	12	.	.	PUNCT
admet-737	224	1	[	[	X
admet-737	224	2	33	33	NUM
admet-737	224	3	]	]	PUNCT
admet-737	224	4	c.	c.	PROPN
admet-737	224	5	palaric	palaric	PROPN
admet-737	224	6	,	,	PUNCT
admet-737	224	7	r.	r.	PROPN
admet-737	224	8	molinié	molinié	PROPN
admet-737	224	9	,	,	PUNCT
admet-737	224	10	d.	d.	PROPN
admet-737	224	11	cailleu	cailleu	PROPN
admet-737	224	12	,	,	PUNCT
admet-737	224	13	j.-x	j.-x	NOUN
admet-737	224	14	.	.	PUNCT
admet-737	225	1	fontaine	fontaine	PROPN
admet-737	225	2	,	,	PUNCT
admet-737	225	3	d.	d.	PROPN
admet-737	225	4	mathiron	mathiron	PROPN
admet-737	225	5	,	,	PUNCT
admet-737	225	6	f.	f.	PROPN
admet-737	225	7	mesnard	mesnard	PROPN
admet-737	225	8	,	,	PUNCT
admet-737	225	9	y.	y.	PROPN
admet-737	225	10	gut	gut	PROPN
admet-737	225	11	,	,	PUNCT
admet-737	225	12	t.	t.	NOUN
admet-737	225	13	renaud	renaud	NOUN
admet-737	225	14	,	,	PUNCT
admet-737	225	15	a.	a.	NOUN
admet-737	225	16	petit	petit	PROPN
admet-737	225	17	,	,	PUNCT
admet-737	225	18	s.	s.	PROPN
admet-737	225	19	pilard	pilard	PROPN
admet-737	225	20	.	.	PUNCT
admet-737	226	1	a	a	DET
admet-737	226	2	deeper	deep	ADJ
admet-737	226	3	investigation	investigation	NOUN
admet-737	226	4	of	of	ADP
admet-737	226	5	drug	drug	NOUN
admet-737	226	6	degradation	degradation	NOUN
admet-737	226	7	mixtures	mixture	NOUN
admet-737	226	8	using	use	VERB
admet-737	226	9	a	a	DET
admet-737	226	10	combination	combination	NOUN
admet-737	226	11	of	of	ADP
admet-737	226	12	ms	ms	NOUN
admet-737	226	13	and	and	CCONJ
admet-737	226	14	nmr	nmr	NOUN
admet-737	226	15	data	datum	NOUN
admet-737	226	16	:	:	PUNCT
admet-737	226	17	application	application	NOUN
admet-737	226	18	to	to	PART
admet-737	226	19	indapamide	indapamide	VERB
admet-737	226	20	.	.	PUNCT
admet-737	227	1	molecules	molecule	NOUN
admet-737	227	2	24	24	NUM
admet-737	227	3	(	(	PUNCT
admet-737	227	4	2019	2019	NUM
admet-737	227	5	)	)	PUNCT
admet-737	227	6	e1764	e1764	NOUN
admet-737	227	7	.	.	PUNCT
admet-737	228	1	[	[	X
admet-737	228	2	34	34	NUM
admet-737	228	3	]	]	X
admet-737	228	4	p.	p.	PROPN
admet-737	228	5	saveyn	saveyn	PROPN
admet-737	228	6	,	,	PUNCT
admet-737	228	7	e.	e.	PROPN
admet-737	228	8	cocquyt	cocquyt	PROPN
admet-737	228	9	,	,	PUNCT
admet-737	228	10	w.	w.	PROPN
admet-737	228	11	zhu	zhu	PROPN
admet-737	228	12	,	,	PUNCT
admet-737	228	13	d.	d.	PROPN
admet-737	228	14	sinnaeve	sinnaeve	PROPN
admet-737	228	15	,	,	PUNCT
admet-737	228	16	k.	k.	PROPN
admet-737	228	17	haustraete	haustraete	PROPN
admet-737	228	18	,	,	PUNCT
admet-737	228	19	j.c	j.c	PROPN
admet-737	228	20	.	.	PROPN
admet-737	228	21	martins	martins	PROPN
admet-737	228	22	,	,	PUNCT
admet-737	228	23	p.	p.	NOUN
admet-737	228	24	van	van	PROPN
admet-737	228	25	der	der	PROPN
admet-737	228	26	meeren	meeren	NOUN
admet-737	228	27	.	.	PUNCT
admet-737	229	1	solubilization	solubilization	NOUN
admet-737	229	2	of	of	ADP
admet-737	229	3	flurbiprofen	flurbiprofen	NOUN
admet-737	229	4	within	within	ADP
admet-737	229	5	non	non	ADJ
admet-737	229	6	-	-	ADJ
admet-737	229	7	ionic	ionic	ADJ
admet-737	229	8	tween	tween	NOUN
admet-737	229	9	20	20	NUM
admet-737	229	10	surfactant	surfactant	ADJ
admet-737	229	11	micelles	micelle	NOUN
admet-737	229	12	:	:	PUNCT
admet-737	229	13	a	a	DET
admet-737	229	14	19	19	NUM
admet-737	229	15	f	f	NOUN
admet-737	229	16	and	and	CCONJ
admet-737	229	17	1h	1h	NUM
admet-737	229	18	nmr	nmr	NOUN
admet-737	229	19	study	study	NOUN
admet-737	229	20	.	.	PUNCT
admet-737	230	1	physical	physical	ADJ
admet-737	230	2	chemistry	chemistry	NOUN
admet-737	230	3	chemical	chemical	PROPN
admet-737	230	4	physics	physics	PROPN
admet-737	230	5	11	11	NUM
admet-737	230	6	(	(	PUNCT
admet-737	230	7	2009	2009	NUM
admet-737	230	8	)	)	PUNCT
admet-737	230	9	5462	5462	NUM
admet-737	230	10	-	-	SYM
admet-737	230	11	5468	5468	NUM
admet-737	230	12	.	.	PUNCT
admet-737	231	1	[	[	X
admet-737	231	2	35	35	NUM
admet-737	231	3	]	]	PUNCT
admet-737	231	4	j.	j.	PROPN
admet-737	231	5	alonso	alonso	PROPN
admet-737	231	6	,	,	PUNCT
admet-737	231	7	c.	c.	PROPN
admet-737	231	8	arús	arús	PROPN
admet-737	231	9	,	,	PUNCT
admet-737	231	10	w.m	w.m	PROPN
admet-737	231	11	.	.	PROPN
admet-737	231	12	westler	westler	NOUN
admet-737	231	13	,	,	PUNCT
admet-737	231	14	j.l	j.l	PROPN
admet-737	231	15	.	.	PROPN
admet-737	231	16	markley	markley	PROPN
admet-737	231	17	.	.	PUNCT
admet-737	232	1	two	two	NUM
admet-737	232	2	-	-	PUNCT
admet-737	232	3	dimensional	dimensional	ADJ
admet-737	232	4	correlated	correlate	VERB
admet-737	232	5	spectroscopy	spectroscopy	NOUN
admet-737	232	6	(	(	PUNCT
admet-737	232	7	cosy	cosy	PROPN
admet-737	232	8	)	)	PUNCT
admet-737	232	9	of	of	ADP
admet-737	232	10	intact	intact	ADJ
admet-737	232	11	frog	frog	ADJ
admet-737	232	12	muscle	muscle	NOUN
admet-737	232	13	:	:	PUNCT
admet-737	232	14	spectral	spectral	ADJ
admet-737	232	15	pattern	pattern	NOUN
admet-737	232	16	characterization	characterization	NOUN
admet-737	232	17	and	and	CCONJ
admet-737	232	18	lactate	lactate	NOUN
admet-737	232	19	quantitation	quantitation	NOUN
admet-737	232	20	.	.	PUNCT
admet-737	233	1	magnetic	magnetic	ADJ
admet-737	233	2	resonance	resonance	NOUN
admet-737	233	3	in	in	ADP
admet-737	233	4	medicine	medicine	NOUN
admet-737	233	5	11	11	NUM
admet-737	233	6	(	(	PUNCT
admet-737	233	7	1989	1989	NUM
admet-737	233	8	)	)	PUNCT
admet-737	233	9	316	316	NUM
admet-737	233	10	-	-	SYM
admet-737	233	11	330	330	NUM
admet-737	233	12	.	.	PUNCT
admet-737	234	1	[	[	X
admet-737	234	2	36	36	NUM
admet-737	234	3	]	]	PUNCT
admet-737	234	4	p.	p.	PROPN
admet-737	234	5	giraudeau	giraudeau	PROPN
admet-737	234	6	.	.	PUNCT
admet-737	235	1	quantitative	quantitative	ADJ
admet-737	235	2	2d	2d	NUM
admet-737	235	3	liquid	liquid	ADJ
admet-737	235	4	-	-	PUNCT
admet-737	235	5	state	state	NOUN
admet-737	235	6	nmr	nmr	NOUN
admet-737	235	7	.	.	PUNCT
admet-737	236	1	magnetic	magnetic	ADJ
admet-737	236	2	resonance	resonance	NOUN
admet-737	236	3	in	in	ADP
admet-737	236	4	chemistry	chemistry	NOUN
admet-737	236	5	52	52	NUM
admet-737	236	6	(	(	PUNCT
admet-737	236	7	2014	2014	NUM
admet-737	236	8	)	)	PUNCT
admet-737	236	9	259272	259272	NUM
admet-737	236	10	.	.	PUNCT
admet-737	237	1	[	[	X
admet-737	237	2	37	37	NUM
admet-737	237	3	]	]	PUNCT
admet-737	237	4	x.	x.	NOUN
admet-737	237	5	li	li	PROPN
admet-737	237	6	,	,	PUNCT
admet-737	237	7	k.	k.	PROPN
admet-737	237	8	hu	hu	PROPN
admet-737	237	9	,	,	PUNCT
admet-737	237	10	quantitative	quantitative	ADJ
admet-737	237	11	nmr	nmr	NOUN
admet-737	237	12	studies	study	NOUN
admet-737	237	13	of	of	ADP
admet-737	237	14	multiple	multiple	ADJ
admet-737	237	15	compound	compound	NOUN
admet-737	237	16	mixtures	mixture	NOUN
admet-737	237	17	,	,	PUNCT
admet-737	237	18	annual	annual	ADJ
admet-737	237	19	reports	report	NOUN
admet-737	237	20	on	on	ADP
admet-737	237	21	nmr	nmr	NOUN
admet-737	237	22	spectroscopy	spectroscopy	NOUN
admet-737	237	23	,	,	PUNCT
admet-737	237	24	elsevier2017	elsevier2017	PROPN
admet-737	237	25	,	,	PUNCT
admet-737	237	26	pp	pp	PROPN
admet-737	237	27	.	.	PUNCT
admet-737	237	28	85	85	NUM
admet-737	237	29	-	-	SYM
admet-737	237	30	143	143	NUM
admet-737	237	31	.	.	PUNCT
admet-737	238	1	[	[	X
admet-737	238	2	38	38	NUM
admet-737	238	3	]	]	PUNCT
admet-737	238	4	g.	g.	PROPN
admet-737	238	5	dufour	dufour	PROPN
admet-737	238	6	,	,	PUNCT
admet-737	238	7	b.	b.	PROPN
admet-737	238	8	evrard	evrard	PROPN
admet-737	238	9	,	,	PUNCT
admet-737	238	10	p.	p.	PROPN
admet-737	238	11	de	de	X
admet-737	238	12	tullio	tullio	PROPN
admet-737	238	13	.	.	PUNCT
admet-737	239	1	2d	2d	NOUN
admet-737	239	2	-	-	PUNCT
admet-737	239	3	cosy	cosy	ADJ
admet-737	239	4	nmr	nmr	NOUN
admet-737	239	5	spectroscopy	spectroscopy	VERB
admet-737	239	6	as	as	ADP
admet-737	239	7	a	a	DET
admet-737	239	8	quantitative	quantitative	ADJ
admet-737	239	9	tool	tool	NOUN
admet-737	239	10	in	in	ADP
admet-737	239	11	biological	biological	ADJ
admet-737	239	12	matrix	matrix	NOUN
admet-737	239	13	:	:	PUNCT
admet-737	239	14	application	application	NOUN
admet-737	239	15	to	to	ADP
admet-737	239	16	cyclodextrins	cyclodextrin	NOUN
admet-737	239	17	.	.	PUNCT
admet-737	240	1	the	the	DET
admet-737	240	2	aaps	aaps	PROPN
admet-737	240	3	journal	journal	PROPN
admet-737	240	4	17	17	NUM
admet-737	240	5	(	(	PUNCT
admet-737	240	6	2015	2015	NUM
admet-737	240	7	)	)	PUNCT
admet-737	240	8	1501	1501	NUM
admet-737	240	9	-	-	SYM
admet-737	240	10	1510	1510	NUM
admet-737	240	11	.	.	PUNCT
admet-737	241	1	[	[	X
admet-737	241	2	39	39	NUM
admet-737	241	3	]	]	PUNCT
admet-737	241	4	p.	p.	PROPN
admet-737	241	5	hodge	hodge	PROPN
admet-737	241	6	,	,	PUNCT
admet-737	241	7	p.	p.	PROPN
admet-737	241	8	monvisade	monvisade	PROPN
admet-737	241	9	,	,	PUNCT
admet-737	241	10	g.a	g.a	PROPN
admet-737	241	11	.	.	PROPN
admet-737	241	12	morris	morris	PROPN
admet-737	241	13	,	,	PUNCT
admet-737	241	14	i.	i.	PROPN
admet-737	241	15	preece	preece	PROPN
admet-737	241	16	.	.	PUNCT
admet-737	242	1	a	a	DET
admet-737	242	2	novel	novel	ADJ
admet-737	242	3	nmr	nmr	NOUN
admet-737	242	4	method	method	NOUN
admet-737	242	5	for	for	ADP
admet-737	242	6	screening	screen	VERB
admet-737	242	7	soluble	soluble	ADJ
admet-737	242	8	compound	compound	NOUN
admet-737	242	9	libraries	library	NOUN
admet-737	242	10	.	.	PUNCT
admet-737	243	1	chemical	chemical	NOUN
admet-737	243	2	communications	communication	NOUN
admet-737	243	3	(	(	PUNCT
admet-737	243	4	2001	2001	NUM
admet-737	243	5	)	)	PUNCT
admet-737	243	6	239	239	NUM
admet-737	243	7	-	-	SYM
admet-737	243	8	240	240	NUM
admet-737	243	9	.	.	PUNCT
admet-737	244	1	[	[	X
admet-737	244	2	40	40	NUM
admet-737	244	3	]	]	PUNCT
admet-737	244	4	s.	s.	PROPN
admet-737	244	5	lapenna	lapenna	PROPN
admet-737	244	6	,	,	PUNCT
admet-737	244	7	a.r	a.r	PROPN
admet-737	244	8	.	.	PROPN
admet-737	244	9	bilia	bilia	PROPN
admet-737	244	10	,	,	PUNCT
admet-737	244	11	g.a	g.a	PROPN
admet-737	244	12	.	.	PROPN
admet-737	244	13	morris	morris	PROPN
admet-737	244	14	,	,	PUNCT
admet-737	244	15	m.	m.	PROPN
admet-737	244	16	nilsson	nilsson	PROPN
admet-737	244	17	.	.	PUNCT
admet-737	245	1	novel	novel	PROPN
admet-737	245	2	artemisinin	artemisinin	PROPN
admet-737	245	3	and	and	CCONJ
admet-737	245	4	curcumin	curcumin	NOUN
admet-737	245	5	micellar	micellar	NOUN
admet-737	245	6	formulations	formulation	NOUN
admet-737	245	7	:	:	PUNCT
admet-737	245	8	drug	drug	NOUN
admet-737	245	9	solubility	solubility	NOUN
admet-737	245	10	studies	study	NOUN
admet-737	245	11	by	by	ADP
admet-737	245	12	nmr	nmr	NOUN
admet-737	245	13	spectroscopy	spectroscopy	NOUN
admet-737	245	14	.	.	PUNCT
admet-737	246	1	journal	journal	PROPN
admet-737	246	2	of	of	ADP
admet-737	246	3	pharmaceutical	pharmaceutical	ADJ
admet-737	246	4	sciences	science	NOUN
admet-737	246	5	98	98	NUM
admet-737	246	6	(	(	PUNCT
admet-737	246	7	2009	2009	NUM
admet-737	246	8	)	)	PUNCT
admet-737	246	9	3666	3666	NUM
admet-737	246	10	-	-	PUNCT
admet-737	246	11	3675	3675	NUM
admet-737	246	12	.	.	PUNCT
admet-737	247	1	[	[	X
admet-737	247	2	41	41	NUM
admet-737	247	3	]	]	PUNCT
admet-737	247	4	m.	m.	NOUN
admet-737	247	5	vogtherr	vogtherr	NOUN
admet-737	247	6	,	,	PUNCT
admet-737	247	7	a.	a.	NOUN
admet-737	247	8	marx	marx	PROPN
admet-737	247	9	,	,	PUNCT
admet-737	247	10	a.-c	a.-c	PROPN
admet-737	247	11	.	.	PUNCT
admet-737	248	1	mieden	mieden	PROPN
admet-737	248	2	,	,	PUNCT
admet-737	248	3	c.	c.	PROPN
admet-737	248	4	saal	saal	PROPN
admet-737	248	5	.	.	PUNCT
admet-737	249	1	investigation	investigation	NOUN
admet-737	249	2	of	of	ADP
admet-737	249	3	solubilising	solubilise	VERB
admet-737	249	4	effects	effect	NOUN
admet-737	249	5	of	of	ADP
admet-737	249	6	bile	bile	NOUN
admet-737	249	7	salts	salt	NOUN
admet-737	249	8	on	on	ADP
admet-737	249	9	an	an	DET
admet-737	249	10	active	active	ADJ
admet-737	249	11	pharmaceutical	pharmaceutical	ADJ
admet-737	249	12	ingredient	ingredient	NOUN
admet-737	249	13	with	with	ADP
admet-737	249	14	unusual	unusual	ADJ
admet-737	249	15	ph	ph	ADJ
admet-737	249	16	dependent	dependent	ADJ
admet-737	249	17	solubility	solubility	NOUN
admet-737	249	18	by	by	ADP
admet-737	249	19	nmr	nmr	NOUN
admet-737	249	20	spectroscopy	spectroscopy	NOUN
admet-737	249	21	.	.	PUNCT
admet-737	250	1	european	european	ADJ
admet-737	250	2	journal	journal	PROPN
admet-737	250	3	of	of	ADP
admet-737	250	4	pharmaceutics	pharmaceutic	NOUN
admet-737	250	5	and	and	CCONJ
admet-737	250	6	biopharmaceutics	biopharmaceutic	NOUN
admet-737	250	7	92	92	NUM
admet-737	250	8	(	(	PUNCT
admet-737	250	9	2015	2015	NUM
admet-737	250	10	)	)	PUNCT
admet-737	250	11	32	32	NUM
admet-737	250	12	-	-	SYM
admet-737	250	13	41	41	NUM
admet-737	250	14	.	.	PUNCT
admet-737	251	1	[	[	X
admet-737	251	2	42	42	NUM
admet-737	251	3	]	]	X
admet-737	251	4	h.	h.	PROPN
admet-737	251	5	mo	mo	PROPN
admet-737	251	6	,	,	PUNCT
admet-737	251	7	k.m	k.m	PROPN
admet-737	251	8	.	.	PROPN
admet-737	251	9	balko	balko	PROPN
admet-737	251	10	,	,	PUNCT
admet-737	251	11	d.a	d.a	PROPN
admet-737	251	12	.	.	PROPN
admet-737	251	13	colby	colby	PROPN
admet-737	251	14	.	.	PUNCT
admet-737	252	1	a	a	DET
admet-737	252	2	practical	practical	ADJ
admet-737	252	3	deuterium	deuterium	NOUN
admet-737	252	4	-	-	PUNCT
admet-737	252	5	free	free	ADJ
admet-737	252	6	nmr	nmr	NOUN
admet-737	252	7	method	method	NOUN
admet-737	252	8	for	for	ADP
admet-737	252	9	the	the	DET
admet-737	252	10	rapid	rapid	ADJ
admet-737	252	11	determination	determination	NOUN
admet-737	252	12	of	of	ADP
admet-737	252	13	1	1	NUM
admet-737	252	14	-	-	PUNCT
admet-737	252	15	octanol	octanol	NOUN
admet-737	252	16	/	/	SYM
admet-737	252	17	water	water	NOUN
admet-737	252	18	partition	partition	NOUN
admet-737	252	19	coefficients	coefficient	NOUN
admet-737	252	20	of	of	ADP
admet-737	252	21	pharmaceutical	pharmaceutical	ADJ
admet-737	252	22	agents	agent	NOUN
admet-737	252	23	.	.	PUNCT
admet-737	253	1	bioorg	bioorg	PROPN
admet-737	253	2	med	med	PROPN
admet-737	253	3	chem	chem	NOUN
admet-737	253	4	lett	lett	NOUN
admet-737	253	5	20	20	NUM
admet-737	253	6	(	(	PUNCT
admet-737	253	7	2010	2010	NUM
admet-737	253	8	)	)	PUNCT
admet-737	253	9	6712	6712	NUM
admet-737	253	10	-	-	PUNCT
admet-737	253	11	6715	6715	NUM
admet-737	253	12	.	.	PUNCT
admet-737	254	1	admet	admet	PROPN
admet-737	254	2	&	&	CCONJ
admet-737	254	3	dmpk	dmpk	PROPN
admet-737	254	4	7(4	7(4	NUM
admet-737	254	5	)	)	PUNCT
admet-737	254	6	(	(	PUNCT
admet-737	254	7	2019	2019	NUM
admet-737	254	8	)	)	PUNCT
admet-737	254	9	242	242	NUM
admet-737	254	10	-	-	SYM
admet-737	254	11	251	251	NUM
admet-737	254	12	nmr	nmr	NOUN
admet-737	254	13	spectroscopy	spectroscopy	NOUN
admet-737	254	14	in	in	ADP
admet-737	254	15	drug	drug	NOUN
admet-737	254	16	discovery	discovery	NOUN
admet-737	254	17	and	and	CCONJ
admet-737	254	18	development	development	NOUN
admet-737	254	19	doi	doi	PROPN
admet-737	254	20	:	:	PUNCT
admet-737	254	21	10.5599	10.5599	NUM
admet-737	254	22	/	/	SYM
admet-737	254	23	admet.737	admet.737	PROPN
admet-737	254	24	251	251	NUM
admet-737	255	1	[	[	X
admet-737	255	2	43	43	NUM
admet-737	255	3	]	]	X
admet-737	255	4	d.	d.	PROPN
admet-737	255	5	soulsby	soulsby	VERB
admet-737	255	6	,	,	PUNCT
admet-737	255	7	j.a.m	j.a.m	PROPN
admet-737	255	8	.	.	PUNCT
admet-737	256	1	chica	chica	PROPN
admet-737	256	2	.	.	PUNCT
admet-737	257	1	determination	determination	NOUN
admet-737	257	2	of	of	ADP
admet-737	257	3	partition	partition	NOUN
admet-737	257	4	coefficients	coefficient	NOUN
admet-737	257	5	using	use	VERB
admet-737	257	6	1h	1h	NUM
admet-737	257	7	nmr	nmr	NOUN
admet-737	257	8	spectroscopy	spectroscopy	NOUN
admet-737	257	9	and	and	CCONJ
admet-737	257	10	time	time	NOUN
admet-737	257	11	domain	domain	NOUN
admet-737	257	12	complete	complete	ADJ
admet-737	257	13	reduction	reduction	NOUN
admet-737	257	14	to	to	ADP
admet-737	257	15	amplitude	amplitude	NOUN
admet-737	257	16	-	-	PUNCT
admet-737	257	17	frequency	frequency	NOUN
admet-737	257	18	table	table	NOUN
admet-737	257	19	(	(	PUNCT
admet-737	257	20	craft	craft	NOUN
admet-737	257	21	)	)	PUNCT
admet-737	257	22	analysis	analysis	NOUN
admet-737	257	23	.	.	PUNCT
admet-737	258	1	magnetic	magnetic	ADJ
admet-737	258	2	resonance	resonance	NOUN
admet-737	258	3	in	in	ADP
admet-737	258	4	chemistry	chemistry	NOUN
admet-737	258	5	55	55	NUM
admet-737	258	6	(	(	PUNCT
admet-737	258	7	2017	2017	NUM
admet-737	258	8	)	)	PUNCT
admet-737	258	9	724	724	NUM
admet-737	258	10	-	-	SYM
admet-737	258	11	729	729	NUM
admet-737	258	12	.	.	PUNCT
admet-737	259	1	[	[	X
admet-737	259	2	44	44	NUM
admet-737	259	3	]	]	X
admet-737	259	4	h.	h.	PROPN
admet-737	259	5	cumming	cumming	PROPN
admet-737	259	6	,	,	PUNCT
admet-737	259	7	c.	c.	PROPN
admet-737	259	8	rücker	rücker	PROPN
admet-737	259	9	.	.	PUNCT
admet-737	260	1	octanol	octanol	NOUN
admet-737	260	2	–	–	PUNCT
admet-737	260	3	water	water	NOUN
admet-737	260	4	partition	partition	NOUN
admet-737	260	5	coefficient	coefficient	NOUN
admet-737	260	6	measurement	measurement	NOUN
admet-737	260	7	by	by	ADP
admet-737	260	8	a	a	DET
admet-737	260	9	simple	simple	ADJ
admet-737	260	10	1h	1h	NUM
admet-737	260	11	nmr	nmr	NOUN
admet-737	260	12	method	method	NOUN
admet-737	260	13	.	.	PUNCT
admet-737	261	1	acs	acs	PROPN
admet-737	261	2	omega	omega	NOUN
admet-737	261	3	2	2	NUM
admet-737	261	4	(	(	PUNCT
admet-737	261	5	2017	2017	NUM
admet-737	261	6	)	)	PUNCT
admet-737	261	7	6244	6244	NUM
admet-737	261	8	-	-	SYM
admet-737	261	9	6249	6249	NUM
admet-737	261	10	.	.	PUNCT
admet-737	262	1	[	[	X
admet-737	262	2	45	45	NUM
admet-737	262	3	]	]	PUNCT
admet-737	262	4	b.	b.	PROPN
admet-737	262	5	linclau	linclau	PROPN
admet-737	262	6	,	,	PUNCT
admet-737	262	7	z.	z.	PROPN
admet-737	262	8	wang	wang	PROPN
admet-737	262	9	,	,	PUNCT
admet-737	262	10	g.	g.	PROPN
admet-737	262	11	compain	compain	PROPN
admet-737	262	12	,	,	PUNCT
admet-737	262	13	v.	v.	ADP
admet-737	262	14	paumelle	paumelle	PROPN
admet-737	262	15	,	,	PUNCT
admet-737	262	16	c.q	c.q	PROPN
admet-737	262	17	.	.	PROPN
admet-737	262	18	fontenelle	fontenelle	PROPN
admet-737	262	19	,	,	PUNCT
admet-737	262	20	n.	n.	PROPN
admet-737	262	21	wells	wells	PROPN
admet-737	262	22	,	,	PUNCT
admet-737	262	23	a.	a.	PROPN
admet-737	262	24	weymouth	weymouth	PROPN
admet-737	262	25	-	-	PUNCT
admet-737	262	26	wilson	wilson	PROPN
admet-737	262	27	.	.	PUNCT
admet-737	263	1	investigating	investigate	VERB
admet-737	263	2	the	the	DET
admet-737	263	3	influence	influence	NOUN
admet-737	263	4	of	of	ADP
admet-737	263	5	(	(	PUNCT
admet-737	263	6	deoxy)fluorination	deoxy)fluorination	NOUN
admet-737	263	7	on	on	ADP
admet-737	263	8	the	the	DET
admet-737	263	9	lipophilicity	lipophilicity	NOUN
admet-737	263	10	of	of	ADP
admet-737	263	11	non	non	ADJ
admet-737	263	12	-	-	ADJ
admet-737	263	13	uv	uv	ADJ
admet-737	263	14	-	-	PUNCT
admet-737	263	15	active	active	ADJ
admet-737	263	16	fluorinated	fluorinate	VERB
admet-737	263	17	alkanols	alkanol	NOUN
admet-737	263	18	and	and	CCONJ
admet-737	263	19	carbohydrates	carbohydrate	NOUN
admet-737	263	20	by	by	ADP
admet-737	263	21	a	a	DET
admet-737	263	22	new	new	ADJ
admet-737	263	23	log	log	NOUN
admet-737	263	24	 	 	SPACE
admet-737	263	25	p	p	NOUN
admet-737	263	26	determination	determination	NOUN
admet-737	263	27	method	method	NOUN
admet-737	263	28	.	.	PUNCT
admet-737	264	1	angewandte	angewandte	PROPN
admet-737	264	2	chemie	chemie	PROPN
admet-737	264	3	international	international	PROPN
admet-737	264	4	edition	edition	PROPN
admet-737	264	5	55	55	NUM
admet-737	264	6	(	(	PUNCT
admet-737	264	7	2016	2016	NUM
admet-737	264	8	)	)	PUNCT
admet-737	264	9	674	674	NUM
admet-737	264	10	-	-	SYM
admet-737	264	11	678	678	NUM
admet-737	264	12	.	.	PUNCT
admet-737	265	1	[	[	X
admet-737	265	2	46	46	NUM
admet-737	265	3	]	]	PUNCT
admet-737	265	4	z.	z.	PROPN
admet-737	265	5	wang	wang	PROPN
admet-737	265	6	,	,	PUNCT
admet-737	265	7	b.f	b.f	PROPN
admet-737	265	8	.	.	PROPN
admet-737	265	9	jeffries	jeffries	PROPN
admet-737	265	10	,	,	PUNCT
admet-737	265	11	h.r	h.r	PROPN
admet-737	265	12	.	.	PROPN
admet-737	265	13	felstead	felstead	PROPN
admet-737	265	14	,	,	PUNCT
admet-737	265	15	n.j	n.j	PROPN
admet-737	265	16	.	.	PROPN
admet-737	265	17	wells	wells	PROPN
admet-737	265	18	,	,	PUNCT
admet-737	265	19	e.	e.	PROPN
admet-737	265	20	chiarparin	chiarparin	PROPN
admet-737	265	21	,	,	PUNCT
admet-737	265	22	b.	b.	PROPN
admet-737	265	23	linclau	linclau	PROPN
admet-737	265	24	.	.	PUNCT
admet-737	266	1	a	a	DET
admet-737	266	2	new	new	ADJ
admet-737	266	3	straightforward	straightforward	ADJ
admet-737	266	4	method	method	NOUN
admet-737	266	5	for	for	ADP
admet-737	266	6	lipophilicity	lipophilicity	NOUN
admet-737	266	7	(	(	PUNCT
admet-737	266	8	logp	logp	NOUN
admet-737	266	9	)	)	PUNCT
admet-737	266	10	measurement	measurement	NOUN
admet-737	266	11	using	use	VERB
admet-737	266	12	19f	19f	PROPN
admet-737	266	13	nmr	nmr	NOUN
admet-737	266	14	spectroscopy	spectroscopy	NOUN
admet-737	266	15	.	.	PUNCT
admet-737	267	1	j	j	PROPN
admet-737	267	2	vis	vis	X
admet-737	267	3	exp	exp	X
admet-737	267	4	(	(	PUNCT
admet-737	267	5	2019	2019	NUM
admet-737	267	6	)	)	PUNCT
admet-737	267	7	.	.	PUNCT
admet-737	268	1	[	[	X
admet-737	268	2	47	47	NUM
admet-737	268	3	]	]	X
admet-737	268	4	j.	j.	PROPN
admet-737	268	5	bezençon	bezençon	PROPN
admet-737	268	6	,	,	PUNCT
admet-737	268	7	m.b	m.b	PROPN
admet-737	268	8	.	.	PROPN
admet-737	268	9	wittwer	wittwer	PROPN
admet-737	268	10	,	,	PUNCT
admet-737	268	11	b.	b.	PROPN
admet-737	268	12	cutting	cutting	NOUN
admet-737	268	13	,	,	PUNCT
admet-737	268	14	m.	m.	NOUN
admet-737	268	15	smieško	smieško	PROPN
admet-737	268	16	,	,	PUNCT
admet-737	268	17	b.	b.	PROPN
admet-737	268	18	wagner	wagner	PROPN
admet-737	268	19	,	,	PUNCT
admet-737	268	20	m.	m.	PROPN
admet-737	268	21	kansy	kansy	PROPN
admet-737	268	22	,	,	PUNCT
admet-737	268	23	b.	b.	PROPN
admet-737	268	24	ernst	ernst	PROPN
admet-737	268	25	.	.	PUNCT
admet-737	269	1	pka	pka	PROPN
admet-737	269	2	determination	determination	NOUN
admet-737	269	3	by	by	ADP
admet-737	269	4	1h	1h	NUM
admet-737	269	5	nmr	nmr	NOUN
admet-737	269	6	spectroscopy	spectroscopy	NOUN
admet-737	269	7	–	–	PUNCT
admet-737	269	8	an	an	DET
admet-737	269	9	old	old	ADJ
admet-737	269	10	methodology	methodology	NOUN
admet-737	269	11	revisited	revisit	VERB
admet-737	269	12	.	.	PUNCT
admet-737	270	1	journal	journal	NOUN
admet-737	270	2	of	of	ADP
admet-737	270	3	pharmaceutical	pharmaceutical	NOUN
admet-737	270	4	and	and	CCONJ
admet-737	270	5	biomedical	biomedical	ADJ
admet-737	270	6	analysis	analysis	NOUN
admet-737	270	7	93	93	NUM
admet-737	270	8	(	(	PUNCT
admet-737	270	9	2014	2014	NUM
admet-737	270	10	)	)	PUNCT
admet-737	270	11	147	147	NUM
admet-737	270	12	-	-	SYM
admet-737	270	13	155	155	NUM
admet-737	270	14	.	.	PUNCT
admet-737	271	1	[	[	X
admet-737	271	2	48	48	NUM
admet-737	271	3	]	]	PUNCT
admet-737	271	4	a.	a.	NOUN
admet-737	271	5	mumcu	mumcu	PROPN
admet-737	271	6	,	,	PUNCT
admet-737	271	7	h.	h.	PROPN
admet-737	271	8	küçükbay	küçükbay	PROPN
admet-737	271	9	.	.	PUNCT
admet-737	272	1	determination	determination	NOUN
admet-737	272	2	of	of	ADP
admet-737	272	3	pka	pka	PROPN
admet-737	272	4	values	value	NOUN
admet-737	272	5	of	of	ADP
admet-737	272	6	some	some	DET
admet-737	272	7	novel	novel	ADJ
admet-737	272	8	benzimidazole	benzimidazole	NOUN
admet-737	272	9	salts	salt	NOUN
admet-737	272	10	by	by	ADP
admet-737	272	11	using	use	VERB
admet-737	272	12	a	a	DET
admet-737	272	13	new	new	ADJ
admet-737	272	14	approach	approach	NOUN
admet-737	272	15	with	with	ADP
admet-737	272	16	1h	1h	NUM
admet-737	272	17	nmr	nmr	NOUN
admet-737	272	18	spectroscopy	spectroscopy	NOUN
admet-737	272	19	.	.	PUNCT
admet-737	273	1	magnetic	magnetic	ADJ
admet-737	273	2	resonance	resonance	NOUN
admet-737	273	3	in	in	ADP
admet-737	273	4	chemistry	chemistry	NOUN
admet-737	273	5	53	53	NUM
admet-737	273	6	(	(	PUNCT
admet-737	273	7	2015	2015	NUM
admet-737	273	8	)	)	PUNCT
admet-737	273	9	1024	1024	NUM
admet-737	273	10	-	-	SYM
admet-737	273	11	1030	1030	NUM
admet-737	273	12	.	.	PUNCT
admet-737	274	1	©	©	NOUN
admet-737	274	2	2019	2019	NUM
admet-737	274	3	by	by	ADP
admet-737	274	4	the	the	DET
admet-737	274	5	authors	author	NOUN
admet-737	274	6	;	;	PUNCT
admet-737	274	7	licensee	licensee	PROPN
admet-737	274	8	iapc	iapc	PROPN
admet-737	274	9	,	,	PUNCT
admet-737	274	10	zagreb	zagreb	PROPN
admet-737	274	11	,	,	PUNCT
admet-737	274	12	croatia	croatia	PROPN
admet-737	274	13	.	.	PUNCT
admet-737	275	1	this	this	DET
admet-737	275	2	article	article	NOUN
admet-737	275	3	is	be	AUX
admet-737	275	4	an	an	DET
admet-737	275	5	open	open	ADJ
admet-737	275	6	-	-	PUNCT
admet-737	275	7	access	access	NOUN
admet-737	275	8	article	article	NOUN
admet-737	275	9	distributed	distribute	VERB
admet-737	275	10	under	under	ADP
admet-737	275	11	the	the	DET
admet-737	275	12	terms	term	NOUN
admet-737	275	13	and	and	CCONJ
admet-737	275	14	conditions	condition	NOUN
admet-737	275	15	of	of	ADP
admet-737	275	16	the	the	DET
admet-737	275	17	creative	creative	ADJ
admet-737	275	18	commons	common	NOUN
admet-737	275	19	attribution	attribution	NOUN
admet-737	275	20	license	license	NOUN
admet-737	275	21	(	(	PUNCT
admet-737	275	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-737	275	23	)	)	PUNCT
admet-737	275	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN