id	sid	tid	token	lemma	pos
admet-757	1	1	revisiting	revisit	VERB
admet-757	1	2	the	the	DET
admet-757	1	3	application	application	NOUN
admet-757	1	4	of	of	ADP
admet-757	1	5	immobilized	immobilized	ADJ
admet-757	1	6	artificial	artificial	ADJ
admet-757	1	7	membrane	membrane	NOUN
admet-757	1	8	(	(	PUNCT
admet-757	1	9	iam	iam	PROPN
admet-757	1	10	)	)	PUNCT
admet-757	1	11	chromatography	chromatography	NOUN
admet-757	1	12	to	to	PART
admet-757	1	13	estimate	estimate	VERB
admet-757	1	14	in	in	ADP
admet-757	1	15	vivo	vivo	ADJ
admet-757	1	16	distribution	distribution	NOUN
admet-757	1	17	properties	property	NOUN
admet-757	1	18	of	of	ADP
admet-757	1	19	drug	drug	NOUN
admet-757	1	20	discovery	discovery	NOUN
admet-757	1	21	compounds	compound	NOUN
admet-757	1	22	based	base	VERB
admet-757	1	23	on	on	ADP
admet-757	1	24	the	the	DET
admet-757	1	25	model	model	NOUN
admet-757	1	26	of	of	ADP
admet-757	1	27	marketed	market	VERB
admet-757	1	28	drugs	drug	NOUN
admet-757	1	29	doi	doi	NOUN
admet-757	1	30	:	:	PUNCT
admet-757	1	31	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	1	32	78	78	NUM
admet-757	1	33	admet	admet	X
admet-757	1	34	&	&	CCONJ
admet-757	1	35	dmpk	dmpk	PROPN
admet-757	1	36	8(1	8(1	NOUN
admet-757	1	37	)	)	PUNCT
admet-757	1	38	(	(	PUNCT
admet-757	1	39	2020	2020	NUM
admet-757	1	40	)	)	PUNCT
admet-757	1	41	78	78	NUM
admet-757	1	42	-	-	SYM
admet-757	1	43	97	97	NUM
admet-757	1	44	;	;	PUNCT
admet-757	1	45	doi	doi	NOUN
admet-757	1	46	:	:	PUNCT
admet-757	1	47	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	1	48	open	open	ADJ
admet-757	1	49	access	access	NOUN
admet-757	1	50	:	:	PUNCT
admet-757	1	51	issn	issn	PROPN
admet-757	1	52	:	:	PUNCT
admet-757	1	53	1848	1848	NUM
admet-757	1	54	-	-	SYM
admet-757	1	55	7718	7718	NUM
admet-757	1	56	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-757	1	57	original	original	ADJ
admet-757	1	58	scientific	scientific	ADJ
admet-757	1	59	paper	paper	NOUN
admet-757	1	60	revisiting	revisit	VERB
admet-757	1	61	the	the	DET
admet-757	1	62	application	application	NOUN
admet-757	1	63	of	of	ADP
admet-757	1	64	immobilized	immobilized	ADJ
admet-757	1	65	artificial	artificial	ADJ
admet-757	1	66	membrane	membrane	NOUN
admet-757	1	67	(	(	PUNCT
admet-757	1	68	iam	iam	PROPN
admet-757	1	69	)	)	PUNCT
admet-757	1	70	chromatography	chromatography	NOUN
admet-757	1	71	to	to	PART
admet-757	1	72	estimate	estimate	VERB
admet-757	1	73	in	in	ADP
admet-757	1	74	vivo	vivo	ADJ
admet-757	1	75	distribution	distribution	NOUN
admet-757	1	76	properties	property	NOUN
admet-757	1	77	of	of	ADP
admet-757	1	78	drug	drug	NOUN
admet-757	1	79	discovery	discovery	NOUN
admet-757	1	80	compounds	compound	NOUN
admet-757	1	81	based	base	VERB
admet-757	1	82	on	on	ADP
admet-757	1	83	the	the	DET
admet-757	1	84	model	model	NOUN
admet-757	1	85	of	of	ADP
admet-757	1	86	marketed	market	VERB
admet-757	1	87	drugs	drug	NOUN
admet-757	1	88	klara	klara	PROPN
admet-757	1	89	valko	valko	PROPN
admet-757	1	90	*	*	PROPN
admet-757	1	91	,	,	PUNCT
admet-757	1	92	silvia	silvia	PROPN
admet-757	1	93	rava1	rava1	PROPN
admet-757	1	94	,	,	PUNCT
admet-757	1	95	shenaz	shenaz	PROPN
admet-757	1	96	bunally2	bunally2	PROPN
admet-757	1	97	and	and	CCONJ
admet-757	1	98	scott	scott	PROPN
admet-757	1	99	anderson3	anderson3	PROPN
admet-757	1	100	bio	bio	PROPN
admet-757	1	101	-	-	ADJ
admet-757	1	102	mimetic	mimetic	ADJ
admet-757	1	103	chromatography	chromatography	PROPN
admet-757	1	104	ltd	ltd	PROPN
admet-757	1	105	.	.	PROPN
admet-757	1	106	business	business	NOUN
admet-757	1	107	and	and	CCONJ
admet-757	1	108	technology	technology	NOUN
admet-757	1	109	centre	centre	NOUN
admet-757	1	110	,	,	PUNCT
admet-757	1	111	bessemer	bessemer	PROPN
admet-757	1	112	drive	drive	PROPN
admet-757	1	113	,	,	PUNCT
admet-757	1	114	stevenage	stevenage	PROPN
admet-757	1	115	,	,	PUNCT
admet-757	1	116	sg1	sg1	PROPN
admet-757	1	117	2dx	2dx	NUM
admet-757	1	118	,	,	PUNCT
admet-757	1	119	united	united	ADJ
admet-757	1	120	kingdom	kingdom	PROPN
admet-757	1	121	1	1	NUM
admet-757	1	122	university	university	PROPN
admet-757	1	123	of	of	ADP
admet-757	1	124	pavia	pavia	PROPN
admet-757	1	125	,	,	PUNCT
admet-757	1	126	italy	italy	PROPN
admet-757	1	127	,	,	PUNCT
admet-757	1	128	erasmus	erasmus	PROPN
admet-757	1	129	internship	internship	NOUN
admet-757	1	130	at	at	ADP
admet-757	1	131	bio	bio	ADJ
admet-757	1	132	-	-	ADJ
admet-757	1	133	mimetic	mimetic	ADJ
admet-757	1	134	chromatography	chromatography	PROPN
admet-757	1	135	ltd	ltd	PROPN
admet-757	1	136	.	.	PROPN
admet-757	1	137	business	business	NOUN
admet-757	1	138	and	and	CCONJ
admet-757	1	139	technology	technology	NOUN
admet-757	1	140	centre	centre	NOUN
admet-757	1	141	,	,	PUNCT
admet-757	1	142	bessemer	bessemer	PROPN
admet-757	1	143	drive	drive	PROPN
admet-757	1	144	,	,	PUNCT
admet-757	1	145	stevenage	stevenage	PROPN
admet-757	1	146	,	,	PUNCT
admet-757	1	147	sg1	sg1	PROPN
admet-757	1	148	2dx	2dx	NUM
admet-757	1	149	,	,	PUNCT
admet-757	1	150	united	united	ADJ
admet-757	1	151	kingdom	kingdom	PROPN
admet-757	1	152	2	2	NUM
admet-757	1	153	physicochemical	physicochemical	ADJ
admet-757	1	154	group	group	NOUN
admet-757	1	155	,	,	PUNCT
admet-757	1	156	gsk	gsk	NOUN
admet-757	1	157	,	,	PUNCT
admet-757	1	158	gunnels	gunnels	PROPN
admet-757	1	159	wood	wood	NOUN
admet-757	1	160	road	road	NOUN
admet-757	1	161	,	,	PUNCT
admet-757	1	162	stevenage	stevenage	PROPN
admet-757	1	163	,	,	PUNCT
admet-757	1	164	sg1	sg1	PROPN
admet-757	1	165	2ny	2ny	ADJ
admet-757	1	166	united	united	PROPN
admet-757	1	167	kingdom	kingdom	PROPN
admet-757	1	168	3	3	NUM
admet-757	1	169	regis	regis	PROPN
admet-757	1	170	technologies	technologies	PROPN
admet-757	1	171	inc	inc	PROPN
admet-757	1	172	.	.	PROPN
admet-757	1	173	8210	8210	NUM
admet-757	2	1	austin	austin	PROPN
admet-757	2	2	avenue	avenue	PROPN
admet-757	2	3	morton	morton	PROPN
admet-757	2	4	grove	grove	PROPN
admet-757	2	5	,	,	PUNCT
admet-757	2	6	il	il	PROPN
admet-757	2	7	us	we	PRON
admet-757	2	8	60053	60053	NUM
admet-757	2	9	*	*	PUNCT
admet-757	2	10	corresponding	correspond	VERB
admet-757	2	11	author	author	NOUN
admet-757	2	12	:	:	PUNCT
admet-757	2	13	e	e	NOUN
admet-757	2	14	-	-	NOUN
admet-757	2	15	mail	mail	NOUN
admet-757	2	16	:	:	PUNCT
admet-757	2	17	klara_valko@bio-mimetic-chromatography.com	klara_valko@bio-mimetic-chromatography.com	NOUN
admet-757	2	18	;	;	PUNCT
admet-757	2	19	received	receive	VERB
admet-757	2	20	:	:	PUNCT
admet-757	2	21	november	november	PROPN
admet-757	2	22	27	27	NUM
admet-757	2	23	,	,	PUNCT
admet-757	2	24	2019	2019	NUM
admet-757	2	25	;	;	PUNCT
admet-757	2	26	revised	revise	VERB
admet-757	2	27	:	:	PUNCT
admet-757	2	28	january	january	PROPN
admet-757	2	29	06	06	NUM
admet-757	2	30	,	,	PUNCT
admet-757	2	31	2020	2020	NUM
admet-757	2	32	;	;	PUNCT
admet-757	2	33	available	available	ADJ
admet-757	2	34	online	online	ADV
admet-757	2	35	:	:	PUNCT
admet-757	2	36	january	january	PROPN
admet-757	2	37	31	31	NUM
admet-757	2	38	,	,	PUNCT
admet-757	2	39	2020	2020	NUM
admet-757	2	40	abstract	abstract	ADV
admet-757	2	41	immobilized	immobilize	VERB
admet-757	2	42	artificial	artificial	ADJ
admet-757	2	43	membrane	membrane	NOUN
admet-757	2	44	(	(	PUNCT
admet-757	2	45	iam	iam	PROPN
admet-757	2	46	)	)	PUNCT
admet-757	2	47	chromatography	chromatography	NOUN
admet-757	2	48	columns	column	NOUN
admet-757	2	49	have	have	AUX
admet-757	2	50	been	be	AUX
admet-757	2	51	used	use	VERB
admet-757	2	52	to	to	PART
admet-757	2	53	model	model	VERB
admet-757	2	54	the	the	DET
admet-757	2	55	in	in	ADP
admet-757	2	56	vivo	vivo	ADJ
admet-757	2	57	distribution	distribution	NOUN
admet-757	2	58	of	of	ADP
admet-757	2	59	drug	drug	NOUN
admet-757	2	60	discovery	discovery	NOUN
admet-757	2	61	compounds	compound	NOUN
admet-757	2	62	.	.	PUNCT
admet-757	3	1	regis	regis	PROPN
admet-757	3	2	technologies	technologies	PROPN
admet-757	3	3	inc	inc	PROPN
admet-757	3	4	.	.	PROPN
admet-757	3	5	,	,	PUNCT
admet-757	3	6	the	the	DET
admet-757	3	7	manufacturer	manufacturer	NOUN
admet-757	3	8	,	,	PUNCT
admet-757	3	9	had	have	VERB
admet-757	3	10	to	to	PART
admet-757	3	11	replace	replace	VERB
admet-757	3	12	the	the	DET
admet-757	3	13	silica	silica	NOUN
admet-757	3	14	support	support	NOUN
admet-757	3	15	and	and	CCONJ
admet-757	3	16	consequently	consequently	ADV
admet-757	3	17	introduced	introduce	VERB
admet-757	3	18	a	a	DET
admet-757	3	19	new	new	ADJ
admet-757	3	20	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	3	21	column	column	NOUN
admet-757	3	22	that	that	PRON
admet-757	3	23	shows	show	VERB
admet-757	3	24	slightly	slightly	ADV
admet-757	3	25	different	different	ADJ
admet-757	3	26	selectivity	selectivity	NOUN
admet-757	3	27	towards	towards	ADP
admet-757	3	28	acidic	acidic	ADJ
admet-757	3	29	and	and	CCONJ
admet-757	3	30	basic	basic	ADJ
admet-757	3	31	compounds	compound	NOUN
admet-757	3	32	.	.	PUNCT
admet-757	4	1	the	the	DET
admet-757	4	2	application	application	NOUN
admet-757	4	3	of	of	ADP
admet-757	4	4	the	the	DET
admet-757	4	5	new	new	ADJ
admet-757	4	6	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	4	7	columns	column	NOUN
admet-757	4	8	has	have	AUX
admet-757	4	9	been	be	AUX
admet-757	4	10	evaluated	evaluate	VERB
admet-757	4	11	and	and	CCONJ
admet-757	4	12	the	the	DET
admet-757	4	13	in	in	ADP
admet-757	4	14	vivo	vivo	ADJ
admet-757	4	15	distribution	distribution	NOUN
admet-757	4	16	models	model	NOUN
admet-757	4	17	have	have	AUX
admet-757	4	18	been	be	AUX
admet-757	4	19	compared	compare	VERB
admet-757	4	20	with	with	ADP
admet-757	4	21	the	the	DET
admet-757	4	22	previous	previous	ADJ
admet-757	4	23	batches	batch	NOUN
admet-757	4	24	of	of	ADP
admet-757	4	25	columns	column	NOUN
admet-757	4	26	.	.	PUNCT
admet-757	5	1	it	it	PRON
admet-757	5	2	was	be	AUX
admet-757	5	3	found	find	VERB
admet-757	5	4	that	that	SCONJ
admet-757	5	5	due	due	ADP
admet-757	5	6	to	to	ADP
admet-757	5	7	the	the	DET
admet-757	5	8	improved	improved	ADJ
admet-757	5	9	endcapping	endcapping	NOUN
admet-757	5	10	of	of	ADP
admet-757	5	11	the	the	DET
admet-757	5	12	silica	silica	NOUN
admet-757	5	13	,	,	PUNCT
admet-757	5	14	some	some	PRON
admet-757	5	15	of	of	ADP
admet-757	5	16	the	the	DET
admet-757	5	17	positively	positively	ADV
admet-757	5	18	charged	charge	VERB
admet-757	5	19	drug	drug	NOUN
admet-757	5	20	molecules	molecule	NOUN
admet-757	5	21	showed	show	VERB
admet-757	5	22	shorter	short	ADJ
admet-757	5	23	retention	retention	NOUN
admet-757	5	24	than	than	SCONJ
admet-757	5	25	previously	previously	ADV
admet-757	5	26	published	publish	VERB
admet-757	5	27	.	.	PUNCT
admet-757	6	1	therefore	therefore	ADV
admet-757	6	2	,	,	PUNCT
admet-757	6	3	the	the	DET
admet-757	6	4	column	column	NOUN
admet-757	6	5	system	system	NOUN
admet-757	6	6	suitability	suitability	NOUN
admet-757	6	7	data	datum	NOUN
admet-757	6	8	have	have	AUX
admet-757	6	9	been	be	AUX
admet-757	6	10	updated	update	VERB
admet-757	6	11	.	.	PUNCT
admet-757	7	1	however	however	ADV
admet-757	7	2	,	,	PUNCT
admet-757	7	3	these	these	DET
admet-757	7	4	differences	difference	NOUN
admet-757	7	5	do	do	AUX
admet-757	7	6	not	not	PART
admet-757	7	7	significantly	significantly	ADV
admet-757	7	8	affect	affect	VERB
admet-757	7	9	the	the	DET
admet-757	7	10	previously	previously	ADV
admet-757	7	11	published	publish	VERB
admet-757	7	12	models	model	NOUN
admet-757	7	13	for	for	ADP
admet-757	7	14	the	the	DET
admet-757	7	15	volume	volume	NOUN
admet-757	7	16	of	of	ADP
admet-757	7	17	distribution	distribution	NOUN
admet-757	7	18	,	,	PUNCT
admet-757	7	19	brain	brain	NOUN
admet-757	7	20	tissue	tissue	NOUN
admet-757	7	21	binding	bind	VERB
admet-757	7	22	and	and	CCONJ
admet-757	7	23	drug	drug	NOUN
admet-757	7	24	efficiency	efficiency	NOUN
admet-757	7	25	.	.	PUNCT
admet-757	8	1	therefore	therefore	ADV
admet-757	8	2	,	,	PUNCT
admet-757	8	3	the	the	DET
admet-757	8	4	published	publish	VERB
admet-757	8	5	models	model	NOUN
admet-757	8	6	can	can	AUX
admet-757	8	7	be	be	AUX
admet-757	8	8	used	use	VERB
admet-757	8	9	with	with	ADP
admet-757	8	10	the	the	DET
admet-757	8	11	new	new	ADJ
admet-757	8	12	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	8	13	columns	column	NOUN
admet-757	8	14	.	.	PUNCT
admet-757	9	1	©	©	PROPN
admet-757	9	2	2020	2020	NUM
admet-757	9	3	by	by	ADP
admet-757	9	4	the	the	DET
admet-757	9	5	authors	author	NOUN
admet-757	9	6	.	.	PUNCT
admet-757	10	1	this	this	DET
admet-757	10	2	article	article	NOUN
admet-757	10	3	is	be	AUX
admet-757	10	4	an	an	DET
admet-757	10	5	open	open	ADJ
admet-757	10	6	-	-	PUNCT
admet-757	10	7	access	access	NOUN
admet-757	10	8	article	article	NOUN
admet-757	10	9	distributed	distribute	VERB
admet-757	10	10	under	under	ADP
admet-757	10	11	the	the	DET
admet-757	10	12	terms	term	NOUN
admet-757	10	13	and	and	CCONJ
admet-757	10	14	conditions	condition	NOUN
admet-757	10	15	of	of	ADP
admet-757	10	16	the	the	DET
admet-757	10	17	creative	creative	ADJ
admet-757	10	18	commons	common	NOUN
admet-757	10	19	attribution	attribution	NOUN
admet-757	10	20	license	license	NOUN
admet-757	10	21	(	(	PUNCT
admet-757	10	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-757	10	23	)	)	PUNCT
admet-757	10	24	.	.	PUNCT
admet-757	11	1	keywords	keyword	VERB
admet-757	11	2	phospholipid	phospholipid	NOUN
admet-757	11	3	binding	bind	VERB
admet-757	11	4	,	,	PUNCT
admet-757	11	5	hplc	hplc	NOUN
admet-757	11	6	,	,	PUNCT
admet-757	11	7	volume	volume	NOUN
admet-757	11	8	of	of	ADP
admet-757	11	9	distribution	distribution	NOUN
admet-757	11	10	,	,	PUNCT
admet-757	11	11	tissue	tissue	NOUN
admet-757	11	12	binding	binding	ADJ
admet-757	11	13	,	,	PUNCT
admet-757	11	14	drug	drug	NOUN
admet-757	11	15	efficiency	efficiency	NOUN
admet-757	11	16	.	.	PUNCT
admet-757	12	1	introduction	introduction	NOUN
admet-757	12	2	pidgeon	pidgeon	NOUN
admet-757	12	3	and	and	CCONJ
admet-757	12	4	venkataran	venkataran	VERB
admet-757	13	1	[	[	X
admet-757	13	2	1	1	X
admet-757	13	3	]	]	PUNCT
admet-757	13	4	patented	patent	VERB
admet-757	13	5	a	a	DET
admet-757	13	6	method	method	NOUN
admet-757	13	7	for	for	ADP
admet-757	13	8	immobilizing	immobilize	VERB
admet-757	13	9	phospholipids	phospholipid	NOUN
admet-757	13	10	on	on	ADP
admet-757	13	11	hplc	hplc	NOUN
admet-757	13	12	-	-	PUNCT
admet-757	13	13	grade	grade	NOUN
admet-757	13	14	silica	silica	NOUN
admet-757	13	15	stationary	stationary	ADJ
admet-757	13	16	phases	phase	NOUN
admet-757	13	17	.	.	PUNCT
admet-757	14	1	the	the	DET
admet-757	14	2	immobilized	immobilize	VERB
admet-757	14	3	phospholipids	phospholipid	NOUN
admet-757	14	4	mimic	mimic	VERB
admet-757	14	5	the	the	DET
admet-757	14	6	lipid	lipid	NOUN
admet-757	14	7	environment	environment	NOUN
admet-757	14	8	of	of	ADP
admet-757	14	9	a	a	DET
admet-757	14	10	fluid	fluid	ADJ
admet-757	14	11	cell	cell	NOUN
admet-757	14	12	membrane	membrane	NOUN
admet-757	14	13	on	on	ADP
admet-757	14	14	a	a	DET
admet-757	14	15	solid	solid	ADJ
admet-757	14	16	matrix	matrix	NOUN
admet-757	14	17	.	.	PUNCT
admet-757	15	1	the	the	DET
admet-757	15	2	retention	retention	NOUN
admet-757	15	3	factors	factor	NOUN
admet-757	15	4	(	(	PUNCT
admet-757	15	5	k	k	NOUN
admet-757	15	6	)	)	PUNCT
admet-757	15	7	of	of	ADP
admet-757	15	8	compounds	compound	NOUN
admet-757	15	9	obtained	obtain	VERB
admet-757	15	10	on	on	ADP
admet-757	15	11	the	the	DET
admet-757	15	12	iam	iam	PROPN
admet-757	15	13	stationary	stationary	ADJ
admet-757	15	14	phase	phase	NOUN
admet-757	15	15	are	be	AUX
admet-757	15	16	proportional	proportional	ADJ
admet-757	15	17	to	to	ADP
admet-757	15	18	their	their	PRON
admet-757	15	19	affinity	affinity	NOUN
admet-757	15	20	(	(	PUNCT
admet-757	15	21	partition	partition	NOUN
admet-757	15	22	coefficient	coefficient	NOUN
admet-757	15	23	)	)	PUNCT
admet-757	15	24	(	(	PUNCT
admet-757	15	25	k	k	NOUN
admet-757	15	26	)	)	PUNCT
admet-757	15	27	to	to	ADP
admet-757	15	28	phospholipids	phospholipid	NOUN
admet-757	15	29	according	accord	VERB
admet-757	15	30	to	to	ADP
admet-757	15	31	the	the	DET
admet-757	15	32	equation	equation	NOUN
admet-757	15	33	(	(	PUNCT
admet-757	15	34	1	1	NUM
admet-757	15	35	):	):	PUNCT
admet-757	15	36	log	log	PROPN
admet-757	15	37	k(iam	k(iam	PROPN
admet-757	15	38	)	)	PUNCT
admet-757	16	1	=	=	PRON
admet-757	16	2	log	log	PROPN
admet-757	16	3	k(iam	k(iam	PROPN
admet-757	16	4	)	)	PUNCT
admet-757	17	1	+	+	NUM
admet-757	17	2	log	log	NOUN
admet-757	17	3	(	(	PUNCT
admet-757	17	4	vs	vs	PROPN
admet-757	17	5	/	/	SYM
admet-757	17	6	vm	vm	NOUN
admet-757	17	7	)	)	PUNCT
admet-757	17	8	(	(	PUNCT
admet-757	17	9	1	1	X
admet-757	17	10	)	)	PUNCT
admet-757	17	11	where	where	SCONJ
admet-757	17	12	k	k	PROPN
admet-757	17	13	is	be	AUX
admet-757	17	14	the	the	DET
admet-757	17	15	retention	retention	NOUN
admet-757	17	16	factor	factor	NOUN
admet-757	17	17	obtained	obtain	VERB
admet-757	17	18	from	from	ADP
admet-757	17	19	the	the	DET
admet-757	17	20	retention	retention	NOUN
admet-757	17	21	time	time	NOUN
admet-757	17	22	(	(	PUNCT
admet-757	17	23	tr	tr	VERB
admet-757	17	24	)	)	PUNCT
admet-757	17	25	and	and	CCONJ
admet-757	17	26	the	the	DET
admet-757	17	27	dead	dead	ADJ
admet-757	17	28	time	time	NOUN
admet-757	17	29	(	(	PUNCT
admet-757	17	30	t0	t0	NOUN
admet-757	17	31	)	)	PUNCT
admet-757	17	32	according	accord	VERB
admet-757	17	33	to	to	ADP
admet-757	17	34	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	17	35	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	17	36	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-757	17	37	mailto:klara_valko@bio-mimetic-chromatography.com	mailto:klara_valko@bio-mimetic-chromatography.com	X
admet-757	17	38	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-757	17	39	admet	admet	PROPN
admet-757	17	40	&	&	CCONJ
admet-757	17	41	dmpk	dmpk	PROPN
admet-757	17	42	8(1	8(1	NOUN
admet-757	17	43	)	)	PUNCT
admet-757	17	44	(	(	PUNCT
admet-757	17	45	2020	2020	NUM
admet-757	17	46	)	)	PUNCT
admet-757	17	47	78	78	NUM
admet-757	17	48	-	-	SYM
admet-757	17	49	97	97	NUM
admet-757	17	50	revisiting	revisit	VERB
admet-757	17	51	the	the	DET
admet-757	17	52	iam	iam	PROPN
admet-757	17	53	chromatography	chromatography	NOUN
admet-757	17	54	doi	doi	PROPN
admet-757	17	55	:	:	PUNCT
admet-757	17	56	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	17	57	79	79	NUM
admet-757	17	58	equation	equation	NOUN
admet-757	17	59	(	(	PUNCT
admet-757	17	60	2	2	NUM
admet-757	17	61	)	)	PUNCT
admet-757	17	62	k	k	NOUN
admet-757	18	1	=	=	PUNCT
admet-757	18	2	(	(	PUNCT
admet-757	18	3	tr	tr	VERB
admet-757	18	4	-	-	PUNCT
admet-757	18	5	t0)/t0	t0)/t0	NOUN
admet-757	18	6	(	(	PUNCT
admet-757	18	7	2	2	NUM
admet-757	18	8	)	)	PUNCT
admet-757	18	9	and	and	CCONJ
admet-757	18	10	vs	vs	ADP
admet-757	18	11	/	/	SYM
admet-757	18	12	vm	vm	PROPN
admet-757	18	13	is	be	AUX
admet-757	18	14	the	the	DET
admet-757	18	15	volume	volume	NOUN
admet-757	18	16	ratio	ratio	NOUN
admet-757	18	17	of	of	ADP
admet-757	18	18	the	the	DET
admet-757	18	19	stationary	stationary	ADJ
admet-757	18	20	and	and	CCONJ
admet-757	18	21	mobile	mobile	ADJ
admet-757	18	22	phases	phase	NOUN
admet-757	18	23	,	,	PUNCT
admet-757	18	24	respectively	respectively	ADV
admet-757	18	25	.	.	PUNCT
admet-757	19	1	many	many	ADJ
admet-757	19	2	drug	drug	NOUN
admet-757	19	3	molecules	molecule	NOUN
admet-757	19	4	bind	bind	VERB
admet-757	19	5	strongly	strongly	ADV
admet-757	19	6	to	to	ADP
admet-757	19	7	phospholipids	phospholipid	NOUN
admet-757	19	8	as	as	SCONJ
admet-757	19	9	it	it	PRON
admet-757	19	10	is	be	AUX
admet-757	19	11	a	a	DET
admet-757	19	12	pre	pre	NOUN
admet-757	19	13	-	-	NOUN
admet-757	19	14	requisite	requisite	ADJ
admet-757	19	15	for	for	ADP
admet-757	19	16	membrane	membrane	NOUN
admet-757	19	17	permeability	permeability	NOUN
admet-757	19	18	.	.	PUNCT
admet-757	20	1	to	to	PART
admet-757	20	2	reduce	reduce	VERB
admet-757	20	3	the	the	DET
admet-757	20	4	retention	retention	NOUN
admet-757	20	5	times	time	NOUN
admet-757	20	6	various	various	ADJ
admet-757	20	7	concentrations	concentration	NOUN
admet-757	20	8	of	of	ADP
admet-757	20	9	acetonitrile	acetonitrile	NOUN
admet-757	20	10	can	can	AUX
admet-757	20	11	be	be	AUX
admet-757	20	12	used	use	VERB
admet-757	20	13	in	in	ADP
admet-757	20	14	the	the	DET
admet-757	20	15	mobile	mobile	ADJ
admet-757	20	16	phase	phase	NOUN
admet-757	20	17	.	.	PUNCT
admet-757	21	1	there	there	PRON
admet-757	21	2	is	be	VERB
admet-757	21	3	a	a	DET
admet-757	21	4	linear	linear	ADJ
admet-757	21	5	relationship	relationship	NOUN
admet-757	21	6	between	between	ADP
admet-757	21	7	the	the	DET
admet-757	21	8	log	log	NOUN
admet-757	21	9	k	k	PROPN
admet-757	21	10	values	value	NOUN
admet-757	21	11	and	and	CCONJ
admet-757	21	12	the	the	DET
admet-757	21	13	percentage	percentage	NOUN
admet-757	21	14	of	of	ADP
admet-757	21	15	acetonitrile	acetonitrile	NOUN
admet-757	21	16	in	in	ADP
admet-757	21	17	the	the	DET
admet-757	21	18	mobile	mobile	ADJ
admet-757	21	19	phase	phase	NOUN
admet-757	21	20	that	that	PRON
admet-757	21	21	allows	allow	VERB
admet-757	21	22	the	the	DET
admet-757	21	23	extrapolation	extrapolation	NOUN
admet-757	21	24	of	of	ADP
admet-757	21	25	the	the	DET
admet-757	21	26	retention	retention	NOUN
admet-757	21	27	factor	factor	NOUN
admet-757	21	28	to	to	ADP
admet-757	21	29	the	the	DET
admet-757	21	30	zero	zero	NUM
admet-757	21	31	percentage	percentage	NOUN
admet-757	21	32	of	of	ADP
admet-757	21	33	acetonitrile	acetonitrile	NOUN
admet-757	21	34	,	,	PUNCT
admet-757	21	35	i.e.	i.e.	X
admet-757	21	36	to	to	ADP
admet-757	21	37	the	the	DET
admet-757	21	38	pure	pure	ADJ
admet-757	21	39	aqueous	aqueous	ADJ
admet-757	21	40	buffer	buffer	NOUN
admet-757	21	41	(	(	PUNCT
admet-757	21	42	log	log	PROPN
admet-757	21	43	k0	k0	PROPN
admet-757	21	44	)	)	PUNCT
admet-757	21	45	as	as	SCONJ
admet-757	21	46	shown	show	VERB
admet-757	21	47	by	by	ADP
admet-757	21	48	equation	equation	NOUN
admet-757	21	49	3	3	NUM
admet-757	21	50	.	.	PUNCT
admet-757	22	1	log	log	VERB
admet-757	22	2	k	k	NOUN
admet-757	23	1	=	=	NOUN
admet-757	23	2	slope	slope	NOUN
admet-757	23	3	∙	∙	PROPN
admet-757	23	4	acn%	acn%	PROPN
admet-757	24	1	+	+	CCONJ
admet-757	25	1	log	log	PROPN
admet-757	25	2	k0	k0	PROPN
admet-757	25	3	(	(	PUNCT
admet-757	25	4	3	3	NUM
admet-757	25	5	)	)	PUNCT
admet-757	25	6	equation	equation	NOUN
admet-757	25	7	3	3	NUM
admet-757	25	8	enables	enable	VERB
admet-757	25	9	the	the	DET
admet-757	25	10	calculation	calculation	NOUN
admet-757	25	11	of	of	ADP
admet-757	25	12	the	the	DET
admet-757	25	13	acetonitrile	acetonitrile	ADJ
admet-757	25	14	concentration	concentration	NOUN
admet-757	25	15	that	that	PRON
admet-757	25	16	is	be	AUX
admet-757	25	17	necessary	necessary	ADJ
admet-757	25	18	to	to	PART
admet-757	25	19	achieve	achieve	VERB
admet-757	25	20	log	log	NOUN
admet-757	25	21	k	k	NOUN
admet-757	25	22	=	=	PUNCT
admet-757	25	23	0	0	PROPN
admet-757	25	24	,	,	PUNCT
admet-757	25	25	when	when	SCONJ
admet-757	25	26	the	the	DET
admet-757	25	27	retention	retention	NOUN
admet-757	25	28	time	time	NOUN
admet-757	25	29	is	be	AUX
admet-757	25	30	exactly	exactly	ADV
admet-757	25	31	double	double	ADJ
admet-757	25	32	that	that	PRON
admet-757	25	33	of	of	ADP
admet-757	25	34	the	the	DET
admet-757	25	35	dead	dead	ADJ
admet-757	25	36	time	time	NOUN
admet-757	25	37	,	,	PUNCT
admet-757	25	38	which	which	PRON
admet-757	25	39	means	mean	VERB
admet-757	25	40	an	an	DET
admet-757	25	41	equal	equal	ADJ
admet-757	25	42	distribution	distribution	NOUN
admet-757	25	43	of	of	ADP
admet-757	25	44	the	the	DET
admet-757	25	45	compound	compound	NOUN
admet-757	25	46	in	in	ADP
admet-757	25	47	the	the	DET
admet-757	25	48	mobile	mobile	NOUN
admet-757	25	49	and	and	CCONJ
admet-757	25	50	the	the	DET
admet-757	25	51	iam	iam	PROPN
admet-757	25	52	stationary	stationary	ADJ
admet-757	25	53	phase	phase	NOUN
admet-757	25	54	[	[	X
admet-757	25	55	2	2	NUM
admet-757	25	56	]	]	PUNCT
admet-757	25	57	.	.	PUNCT
admet-757	26	1	this	this	DET
admet-757	26	2	acetonitrile	acetonitrile	ADJ
admet-757	26	3	concentration	concentration	NOUN
admet-757	26	4	expressed	express	VERB
admet-757	26	5	in	in	ADP
admet-757	26	6	volume	volume	NOUN
admet-757	26	7	percentage	percentage	NOUN
admet-757	26	8	is	be	AUX
admet-757	26	9	called	call	VERB
admet-757	26	10	the	the	DET
admet-757	26	11	chromatographic	chromatographic	ADJ
admet-757	26	12	hydrophobicity	hydrophobicity	NOUN
admet-757	26	13	index	index	NOUN
admet-757	26	14	(	(	PUNCT
admet-757	26	15	chi	chi	PROPN
admet-757	26	16	(	(	PUNCT
admet-757	26	17	iam	iam	PROPN
admet-757	26	18	)	)	PUNCT
admet-757	26	19	)	)	PUNCT
admet-757	27	1	[	[	X
admet-757	27	2	3	3	NUM
admet-757	27	3	]	]	PUNCT
admet-757	27	4	.	.	PUNCT
admet-757	28	1	it	it	PRON
admet-757	28	2	has	have	AUX
admet-757	28	3	also	also	ADV
admet-757	28	4	been	be	AUX
admet-757	28	5	shown	show	VERB
admet-757	28	6	that	that	SCONJ
admet-757	28	7	the	the	DET
admet-757	28	8	chi	chi	NOUN
admet-757	28	9	(	(	PUNCT
admet-757	28	10	iam	iam	PROPN
admet-757	28	11	)	)	PUNCT
admet-757	28	12	values	value	NOUN
admet-757	28	13	have	have	VERB
admet-757	28	14	linear	linear	ADJ
admet-757	28	15	relationships	relationship	NOUN
admet-757	28	16	with	with	ADP
admet-757	28	17	the	the	DET
admet-757	28	18	gradient	gradient	ADJ
admet-757	28	19	retention	retention	NOUN
admet-757	28	20	times	time	NOUN
admet-757	28	21	of	of	ADP
admet-757	28	22	the	the	DET
admet-757	28	23	compounds	compound	NOUN
admet-757	28	24	obtained	obtain	VERB
admet-757	28	25	on	on	ADP
admet-757	28	26	the	the	DET
admet-757	28	27	iam	iam	PROPN
admet-757	28	28	stationary	stationary	ADJ
admet-757	28	29	phases	phase	NOUN
admet-757	28	30	.	.	PUNCT
admet-757	29	1	by	by	ADP
admet-757	29	2	using	use	VERB
admet-757	29	3	an	an	DET
admet-757	29	4	acetonitrile	acetonitrile	ADJ
admet-757	29	5	gradient	gradient	NOUN
admet-757	29	6	of	of	ADP
admet-757	29	7	0	0	NUM
admet-757	29	8	%	%	NOUN
admet-757	29	9	to	to	ADP
admet-757	29	10	a	a	DET
admet-757	29	11	maximum	maximum	NOUN
admet-757	29	12	of	of	ADP
admet-757	29	13	85	85	NUM
admet-757	29	14	%	%	NOUN
admet-757	29	15	the	the	DET
admet-757	29	16	obtained	obtain	VERB
admet-757	29	17	gradient	gradient	NOUN
admet-757	29	18	retention	retention	NOUN
admet-757	29	19	times	time	NOUN
admet-757	29	20	can	can	AUX
admet-757	29	21	be	be	AUX
admet-757	29	22	calibrated	calibrate	VERB
admet-757	29	23	from	from	ADP
admet-757	29	24	the	the	DET
admet-757	29	25	chi	chi	NOUN
admet-757	29	26	(	(	PUNCT
admet-757	29	27	iam	iam	PROPN
admet-757	29	28	)	)	PUNCT
admet-757	29	29	values	value	NOUN
admet-757	29	30	by	by	ADP
admet-757	29	31	using	use	VERB
admet-757	29	32	a	a	DET
admet-757	29	33	set	set	NOUN
admet-757	29	34	of	of	ADP
admet-757	29	35	standards	standard	NOUN
admet-757	29	36	,	,	PUNCT
admet-757	29	37	eliminating	eliminate	VERB
admet-757	29	38	the	the	DET
admet-757	29	39	need	need	NOUN
admet-757	29	40	to	to	PART
admet-757	29	41	carry	carry	VERB
admet-757	29	42	out	out	ADP
admet-757	29	43	isocratic	isocratic	ADJ
admet-757	29	44	measurements	measurement	NOUN
admet-757	29	45	.	.	PUNCT
admet-757	30	1	the	the	DET
admet-757	30	2	so	so	ADV
admet-757	30	3	obtained	obtain	VERB
admet-757	30	4	chi	chi	NOUN
admet-757	30	5	(	(	PUNCT
admet-757	30	6	iam	iam	PROPN
admet-757	30	7	)	)	PUNCT
admet-757	30	8	values	value	NOUN
admet-757	30	9	show	show	VERB
admet-757	30	10	a	a	DET
admet-757	30	11	good	good	ADJ
admet-757	30	12	correlation	correlation	NOUN
admet-757	30	13	to	to	ADP
admet-757	30	14	the	the	DET
admet-757	30	15	log	log	NOUN
admet-757	30	16	k0	k0	PROPN
admet-757	30	17	(	(	PUNCT
admet-757	30	18	iam	iam	PROPN
admet-757	30	19	)	)	PUNCT
admet-757	30	20	values	value	NOUN
admet-757	30	21	,	,	PUNCT
admet-757	30	22	that	that	PRON
admet-757	30	23	are	be	AUX
admet-757	30	24	the	the	DET
admet-757	30	25	extrapolated	extrapolate	VERB
admet-757	30	26	logarithmic	logarithmic	ADJ
admet-757	30	27	retention	retention	NOUN
admet-757	30	28	factors	factor	NOUN
admet-757	30	29	to	to	ADP
admet-757	30	30	0	0	NUM
admet-757	30	31	%	%	NOUN
admet-757	30	32	acetonitrile	acetonitrile	ADJ
admet-757	30	33	concentration	concentration	NOUN
admet-757	30	34	in	in	ADP
admet-757	30	35	the	the	DET
admet-757	30	36	isocratic	isocratic	ADJ
admet-757	30	37	mode	mode	NOUN
admet-757	30	38	.	.	PUNCT
admet-757	31	1	the	the	DET
admet-757	31	2	chromatographic	chromatographic	ADJ
admet-757	31	3	determination	determination	NOUN
admet-757	31	4	of	of	ADP
admet-757	31	5	phospholipid	phospholipid	NOUN
admet-757	31	6	-	-	PUNCT
admet-757	31	7	binding	bind	VERB
admet-757	31	8	is	be	AUX
admet-757	31	9	based	base	VERB
admet-757	31	10	on	on	ADP
admet-757	31	11	measuring	measure	VERB
admet-757	31	12	gradient	gradient	ADJ
admet-757	31	13	retention	retention	NOUN
admet-757	31	14	times	time	NOUN
admet-757	31	15	.	.	PUNCT
admet-757	32	1	it	it	PRON
admet-757	32	2	is	be	AUX
admet-757	32	3	independent	independent	ADJ
admet-757	32	4	of	of	ADP
admet-757	32	5	the	the	DET
admet-757	32	6	amount	amount	NOUN
admet-757	32	7	of	of	ADP
admet-757	32	8	compound	compound	NOUN
admet-757	32	9	injected	inject	VERB
admet-757	32	10	onto	onto	ADP
admet-757	32	11	the	the	DET
admet-757	32	12	column	column	NOUN
admet-757	32	13	,	,	PUNCT
admet-757	32	14	so	so	CCONJ
admet-757	32	15	there	there	PRON
admet-757	32	16	is	be	VERB
admet-757	32	17	no	no	DET
admet-757	32	18	need	need	NOUN
admet-757	32	19	for	for	ADP
admet-757	32	20	quantitative	quantitative	ADJ
admet-757	32	21	analysis	analysis	NOUN
admet-757	32	22	.	.	PUNCT
admet-757	33	1	the	the	DET
admet-757	33	2	time	time	NOUN
admet-757	33	3	measurement	measurement	NOUN
admet-757	33	4	is	be	AUX
admet-757	33	5	very	very	ADV
admet-757	33	6	reproducible	reproducible	ADJ
admet-757	33	7	,	,	PUNCT
admet-757	33	8	and	and	CCONJ
admet-757	33	9	the	the	DET
admet-757	33	10	calibrated	calibrate	VERB
admet-757	33	11	(	(	PUNCT
admet-757	33	12	relative	relative	ADJ
admet-757	33	13	)	)	PUNCT
admet-757	33	14	gradient	gradient	NOUN
admet-757	33	15	retention	retention	NOUN
admet-757	33	16	data	datum	NOUN
admet-757	33	17	are	be	AUX
admet-757	33	18	suitable	suitable	ADJ
admet-757	33	19	for	for	ADP
admet-757	33	20	inter	inter	ADJ
admet-757	33	21	-	-	ADJ
admet-757	33	22	laboratory	laboratory	ADJ
admet-757	33	23	comparison	comparison	NOUN
admet-757	33	24	and	and	CCONJ
admet-757	33	25	application	application	NOUN
admet-757	33	26	in	in	ADP
admet-757	33	27	published	publish	VERB
admet-757	33	28	models	model	NOUN
admet-757	33	29	of	of	ADP
admet-757	33	30	in	in	ADP
admet-757	33	31	vivo	vivo	ADJ
admet-757	33	32	drug	drug	NOUN
admet-757	33	33	distribution	distribution	NOUN
admet-757	33	34	.	.	PUNCT
admet-757	34	1	the	the	DET
admet-757	34	2	data	datum	NOUN
admet-757	34	3	so	so	ADV
admet-757	34	4	obtained	obtain	VERB
admet-757	34	5	can	can	AUX
admet-757	34	6	be	be	AUX
admet-757	34	7	compiled	compile	VERB
admet-757	34	8	in	in	ADP
admet-757	34	9	databases	database	NOUN
admet-757	34	10	and	and	CCONJ
admet-757	34	11	is	be	AUX
admet-757	34	12	suitable	suitable	ADJ
admet-757	34	13	for	for	ADP
admet-757	34	14	use	use	NOUN
admet-757	34	15	in	in	ADP
admet-757	34	16	establishing	establish	VERB
admet-757	34	17	quantitative	quantitative	ADJ
admet-757	34	18	structure	structure	NOUN
admet-757	34	19	retention	retention	NOUN
admet-757	34	20	relationships	relationship	NOUN
admet-757	34	21	,	,	PUNCT
admet-757	34	22	thus	thus	ADV
admet-757	34	23	enabling	enable	VERB
admet-757	34	24	chemists	chemist	NOUN
admet-757	34	25	to	to	PART
admet-757	34	26	design	design	VERB
admet-757	34	27	compounds	compound	NOUN
admet-757	34	28	with	with	ADP
admet-757	34	29	the	the	DET
admet-757	34	30	appropriate	appropriate	ADJ
admet-757	34	31	iam	iam	PROPN
admet-757	34	32	binding	bind	VERB
admet-757	34	33	.	.	PUNCT
admet-757	35	1	the	the	DET
admet-757	35	2	application	application	NOUN
admet-757	35	3	of	of	ADP
admet-757	35	4	iam	iam	PROPN
admet-757	35	5	chromatography	chromatography	NOUN
admet-757	35	6	as	as	ADP
admet-757	35	7	an	an	DET
admet-757	35	8	aid	aid	NOUN
admet-757	35	9	in	in	ADP
admet-757	35	10	drug	drug	NOUN
admet-757	35	11	discovery	discovery	NOUN
admet-757	35	12	has	have	AUX
admet-757	35	13	been	be	AUX
admet-757	35	14	reviewed	review	VERB
admet-757	35	15	extensively	extensively	ADV
admet-757	35	16	in	in	ADP
admet-757	35	17	recent	recent	ADJ
admet-757	35	18	years	year	NOUN
admet-757	36	1	[	[	X
admet-757	36	2	4	4	NUM
admet-757	36	3	-	-	SYM
admet-757	36	4	8	8	NUM
admet-757	36	5	]	]	PUNCT
admet-757	36	6	.	.	PUNCT
admet-757	37	1	the	the	DET
admet-757	37	2	molecular	molecular	ADJ
admet-757	37	3	factors	factor	NOUN
admet-757	37	4	that	that	PRON
admet-757	37	5	influence	influence	VERB
admet-757	37	6	iam	iam	PROPN
admet-757	37	7	retention	retention	NOUN
admet-757	37	8	have	have	AUX
admet-757	37	9	also	also	ADV
admet-757	37	10	been	be	AUX
admet-757	37	11	discussed	discuss	VERB
admet-757	37	12	[	[	X
admet-757	37	13	9,10	9,10	NUM
admet-757	37	14	]	]	X
admet-757	37	15	.	.	PUNCT
admet-757	38	1	it	it	PRON
admet-757	38	2	has	have	AUX
admet-757	38	3	been	be	AUX
admet-757	38	4	found	find	VERB
admet-757	38	5	that	that	SCONJ
admet-757	38	6	iam	iam	PROPN
admet-757	38	7	columns	column	NOUN
admet-757	38	8	retain	retain	VERB
admet-757	38	9	strongly	strongly	ADV
admet-757	38	10	positively	positively	ADV
admet-757	38	11	charged	charge	VERB
admet-757	38	12	compounds	compound	NOUN
admet-757	38	13	as	as	SCONJ
admet-757	38	14	the	the	DET
admet-757	38	15	iam	iam	PROPN
admet-757	38	16	columns	column	NOUN
admet-757	38	17	are	be	AUX
admet-757	38	18	negatively	negatively	ADV
admet-757	38	19	charged	charge	VERB
admet-757	38	20	on	on	ADP
admet-757	38	21	the	the	DET
admet-757	38	22	surface	surface	NOUN
admet-757	38	23	similar	similar	ADJ
admet-757	38	24	to	to	ADP
admet-757	38	25	cell	cell	NOUN
admet-757	38	26	membranes	membrane	NOUN
admet-757	38	27	[	[	X
admet-757	38	28	11	11	NUM
admet-757	38	29	-	-	SYM
admet-757	38	30	13	13	NUM
admet-757	38	31	]	]	PUNCT
admet-757	38	32	.	.	PUNCT
admet-757	39	1	several	several	ADJ
admet-757	39	2	applications	application	NOUN
admet-757	39	3	of	of	ADP
admet-757	39	4	iam	iam	PROPN
admet-757	39	5	chromatography	chromatography	NOUN
admet-757	39	6	have	have	AUX
admet-757	39	7	also	also	ADV
admet-757	39	8	published	publish	VERB
admet-757	39	9	[	[	X
admet-757	39	10	14	14	NUM
admet-757	39	11	]	]	PUNCT
admet-757	39	12	and	and	CCONJ
admet-757	39	13	this	this	PRON
admet-757	39	14	is	be	AUX
admet-757	39	15	summarized	summarize	VERB
admet-757	39	16	below	below	ADV
admet-757	39	17	.	.	PUNCT
admet-757	40	1	intestinal	intestinal	ADJ
admet-757	40	2	absorption	absorption	NOUN
admet-757	40	3	and	and	CCONJ
admet-757	40	4	drug	drug	NOUN
admet-757	40	5	distribution	distribution	NOUN
admet-757	40	6	depend	depend	VERB
admet-757	40	7	on	on	ADP
admet-757	40	8	a	a	DET
admet-757	40	9	compound	compound	NOUN
admet-757	40	10	’s	’s	ADV
admet-757	40	11	partitioning	partition	VERB
admet-757	40	12	into	into	ADP
admet-757	40	13	phospholipids	phospholipid	NOUN
admet-757	40	14	.	.	PUNCT
admet-757	41	1	compounds	compound	NOUN
admet-757	41	2	have	have	VERB
admet-757	41	3	to	to	PART
admet-757	41	4	possess	possess	VERB
admet-757	41	5	a	a	DET
admet-757	41	6	certain	certain	ADJ
admet-757	41	7	degree	degree	NOUN
admet-757	41	8	of	of	ADP
admet-757	41	9	affinity	affinity	NOUN
admet-757	41	10	to	to	ADP
admet-757	41	11	membranes	membrane	NOUN
admet-757	41	12	in	in	ADP
admet-757	41	13	order	order	NOUN
admet-757	41	14	to	to	PART
admet-757	41	15	permeate	permeate	VERB
admet-757	41	16	through	through	ADP
admet-757	41	17	the	the	DET
admet-757	41	18	biological	biological	ADJ
admet-757	41	19	phospholipid	phospholipid	NOUN
admet-757	41	20	bilayers	bilayer	NOUN
admet-757	41	21	.	.	PUNCT
admet-757	42	1	therefore	therefore	ADV
admet-757	42	2	,	,	PUNCT
admet-757	42	3	iam	iam	PROPN
admet-757	42	4	chromatography	chromatography	NOUN
admet-757	42	5	can	can	AUX
admet-757	42	6	provide	provide	VERB
admet-757	42	7	an	an	DET
admet-757	42	8	insight	insight	NOUN
admet-757	42	9	into	into	ADP
admet-757	42	10	the	the	DET
admet-757	42	11	potential	potential	ADJ
admet-757	42	12	intestinal	intestinal	ADJ
admet-757	42	13	absorption	absorption	NOUN
admet-757	42	14	of	of	ADP
admet-757	42	15	compounds	compound	NOUN
admet-757	42	16	[	[	X
admet-757	42	17	15	15	NUM
admet-757	42	18	]	]	PUNCT
admet-757	42	19	.	.	PUNCT
admet-757	43	1	as	as	SCONJ
admet-757	43	2	tissues	tissue	NOUN
admet-757	43	3	represent	represent	VERB
admet-757	43	4	a	a	DET
admet-757	43	5	more	more	ADV
admet-757	43	6	non	non	ADJ
admet-757	43	7	-	-	ADJ
admet-757	43	8	polar	polar	ADJ
admet-757	43	9	lipid	lipid	NOUN
admet-757	43	10	environment	environment	NOUN
admet-757	43	11	relative	relative	ADJ
admet-757	43	12	to	to	ADP
admet-757	43	13	the	the	DET
admet-757	43	14	plasma	plasma	NOUN
admet-757	43	15	,	,	PUNCT
admet-757	43	16	the	the	DET
admet-757	43	17	human	human	ADJ
admet-757	43	18	volume	volume	NOUN
admet-757	43	19	of	of	ADP
admet-757	43	20	distribution	distribution	NOUN
admet-757	43	21	can	can	AUX
admet-757	43	22	be	be	AUX
admet-757	43	23	modelled	model	VERB
admet-757	43	24	by	by	ADP
admet-757	43	25	the	the	DET
admet-757	43	26	binding	bind	VERB
admet-757	43	27	differences	difference	NOUN
admet-757	43	28	between	between	ADP
admet-757	43	29	iam	iam	PROPN
admet-757	43	30	and	and	CCONJ
admet-757	43	31	human	human	ADJ
admet-757	43	32	serum	serum	NOUN
admet-757	43	33	albumin	albumin	PROPN
admet-757	43	34	(	(	PUNCT
admet-757	43	35	hsa	hsa	PROPN
admet-757	43	36	)	)	PUNCT
admet-757	44	1	[	[	X
admet-757	44	2	13,16	13,16	NUM
admet-757	44	3	]	]	PUNCT
admet-757	44	4	,	,	PUNCT
admet-757	44	5	as	as	SCONJ
admet-757	44	6	shown	show	VERB
admet-757	44	7	by	by	ADP
admet-757	44	8	equation	equation	NOUN
admet-757	44	9	(	(	PUNCT
admet-757	44	10	4	4	NUM
admet-757	44	11	):	):	PUNCT
admet-757	44	12	log	log	VERB
admet-757	44	13	vdss=	vdss=	NUM
admet-757	44	14	0.44	0.44	NUM
admet-757	44	15	log	log	NOUN
admet-757	44	16	k	k	PROPN
admet-757	44	17	(	(	PUNCT
admet-757	44	18	iam	iam	PROPN
admet-757	44	19	)	)	PUNCT
admet-757	44	20	–	–	PUNCT
admet-757	44	21	0.22	0.22	NUM
admet-757	44	22	log	log	NOUN
admet-757	44	23	k	k	PROPN
admet-757	44	24	(	(	PUNCT
admet-757	44	25	hsa	hsa	PROPN
admet-757	44	26	)	)	PUNCT
admet-757	44	27	–	–	PUNCT
admet-757	44	28	0.66	0.66	NUM
admet-757	44	29	(	(	PUNCT
admet-757	44	30	4	4	NUM
admet-757	44	31	)	)	PUNCT
admet-757	44	32	the	the	DET
admet-757	44	33	sum	sum	NOUN
admet-757	44	34	of	of	ADP
admet-757	44	35	the	the	DET
admet-757	44	36	albumin	albumin	NOUN
admet-757	44	37	and	and	CCONJ
admet-757	44	38	phospholipid	phospholipid	NOUN
admet-757	44	39	-	-	PUNCT
admet-757	44	40	binding	bind	VERB
admet-757	44	41	inversely	inversely	ADV
admet-757	44	42	correlates	correlate	VERB
admet-757	44	43	to	to	ADP
admet-757	44	44	the	the	DET
admet-757	44	45	unbound	unbound	NOUN
admet-757	44	46	fraction	fraction	NOUN
admet-757	44	47	of	of	ADP
admet-757	44	48	the	the	DET
admet-757	44	49	compounds	compound	NOUN
admet-757	44	50	in	in	ADP
admet-757	44	51	tissues	tissue	NOUN
admet-757	44	52	according	accord	VERB
admet-757	44	53	to	to	ADP
admet-757	44	54	equation	equation	NOUN
admet-757	44	55	(	(	PUNCT
admet-757	44	56	5	5	NUM
admet-757	44	57	)	)	PUNCT
admet-757	44	58	[	[	X
admet-757	44	59	17	17	NUM
admet-757	44	60	]	]	PUNCT
admet-757	44	61	.	.	PUNCT
admet-757	45	1	log	log	VERB
admet-757	45	2	fut	fut	X
admet-757	45	3	=	=	PUNCT
admet-757	45	4	-0.66	-0.66	NUM
admet-757	45	5	log	log	NOUN
admet-757	45	6	k	k	PROPN
admet-757	45	7	(	(	PUNCT
admet-757	45	8	hsa	hsa	PROPN
admet-757	45	9	)	)	PUNCT
admet-757	45	10	–	–	PUNCT
admet-757	45	11	0.52	0.52	NUM
admet-757	45	12	log	log	NOUN
admet-757	45	13	k	k	PROPN
admet-757	45	14	(	(	PUNCT
admet-757	45	15	iam	iam	PROPN
admet-757	45	16	)	)	PUNCT
admet-757	45	17	+	+	CCONJ
admet-757	45	18	0.55	0.55	NUM
admet-757	45	19	(	(	PUNCT
admet-757	45	20	5	5	NUM
admet-757	45	21	)	)	PUNCT
admet-757	45	22	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	46	1	klara	klara	PROPN
admet-757	46	2	valko	valko	PROPN
admet-757	46	3	et	et	PROPN
admet-757	46	4	al	al	PROPN
admet-757	46	5	.	.	PROPN
admet-757	46	6	admet	admet	PROPN
admet-757	46	7	&	&	CCONJ
admet-757	46	8	dmpk	dmpk	PROPN
admet-757	46	9	8(1	8(1	NOUN
admet-757	46	10	)	)	PUNCT
admet-757	46	11	(	(	PUNCT
admet-757	46	12	2020	2020	NUM
admet-757	46	13	)	)	PUNCT
admet-757	46	14	78	78	NUM
admet-757	46	15	-	-	SYM
admet-757	46	16	97	97	NUM
admet-757	46	17	80	80	NUM
admet-757	46	18	the	the	PRON
admet-757	46	19	in	in	ADP
admet-757	46	20	vivo	vivo	ADJ
admet-757	46	21	drug	drug	NOUN
admet-757	46	22	efficiency	efficiency	NOUN
admet-757	46	23	can	can	AUX
admet-757	46	24	be	be	AUX
admet-757	46	25	modelled	model	VERB
admet-757	46	26	by	by	ADP
admet-757	46	27	the	the	DET
admet-757	46	28	sum	sum	NOUN
admet-757	46	29	of	of	ADP
admet-757	46	30	the	the	DET
admet-757	46	31	iam	iam	PROPN
admet-757	46	32	and	and	CCONJ
admet-757	46	33	hsa	hsa	VERB
admet-757	46	34	binding	bind	VERB
admet-757	46	35	of	of	ADP
admet-757	46	36	compounds	compound	NOUN
admet-757	46	37	[	[	X
admet-757	46	38	18	18	NUM
admet-757	46	39	]	]	PUNCT
admet-757	46	40	according	accord	VERB
admet-757	46	41	to	to	ADP
admet-757	46	42	equation	equation	NOUN
admet-757	46	43	6	6	NUM
admet-757	46	44	.	.	PUNCT
admet-757	47	1	the	the	DET
admet-757	47	2	in	in	ADV
admet-757	47	3	vitro	vitro	X
admet-757	47	4	drugeff	drugeff	NOUN
admet-757	47	5	shows	show	VERB
admet-757	47	6	an	an	DET
admet-757	47	7	excellent	excellent	ADJ
admet-757	47	8	correlation	correlation	NOUN
admet-757	47	9	with	with	ADP
admet-757	47	10	the	the	DET
admet-757	47	11	in	in	ADP
admet-757	47	12	vivo	vivo	NOUN
admet-757	47	13	drugeff	drugeff	NOUN
admet-757	47	14	.	.	PUNCT
admet-757	48	1	drug	drug	NOUN
admet-757	48	2	efficiency	efficiency	NOUN
admet-757	48	3	and	and	CCONJ
admet-757	48	4	potency	potency	NOUN
admet-757	48	5	enables	enable	VERB
admet-757	48	6	early	early	ADJ
admet-757	48	7	dose	dose	NOUN
admet-757	48	8	estimation	estimation	NOUN
admet-757	48	9	as	as	ADP
admet-757	48	10	drug	drug	NOUN
admet-757	48	11	efficiency	efficiency	NOUN
admet-757	48	12	approximates	approximate	NOUN
admet-757	48	13	to	to	ADP
admet-757	48	14	the	the	DET
admet-757	48	15	proportion	proportion	NOUN
admet-757	48	16	of	of	ADP
admet-757	48	17	free	free	ADJ
admet-757	48	18	drug	drug	NOUN
admet-757	48	19	concentration	concentration	NOUN
admet-757	48	20	and	and	CCONJ
admet-757	48	21	dose	dose	VERB
admet-757	48	22	[	[	X
admet-757	48	23	19	19	NUM
admet-757	48	24	]	]	PUNCT
admet-757	48	25	.	.	PUNCT
admet-757	49	1	log	log	VERB
admet-757	49	2	drugeff=	drugeff=	NUM
admet-757	49	3	2	2	NUM
admet-757	49	4	(	(	PUNCT
admet-757	49	5	0.23	0.23	NUM
admet-757	49	6	log	log	NOUN
admet-757	49	7	k	k	PROPN
admet-757	49	8	(	(	PUNCT
admet-757	49	9	hsa	hsa	PROPN
admet-757	49	10	)	)	PUNCT
admet-757	49	11	+	+	NUM
admet-757	49	12	0.43	0.43	NUM
admet-757	49	13	log	log	NOUN
admet-757	49	14	k	k	PROPN
admet-757	49	15	(	(	PUNCT
admet-757	49	16	iam	iam	PROPN
admet-757	49	17	)	)	PUNCT
admet-757	49	18	0.72	0.72	NUM
admet-757	49	19	)	)	PUNCT
admet-757	49	20	(	(	PUNCT
admet-757	49	21	6	6	X
admet-757	49	22	)	)	PUNCT
admet-757	49	23	it	it	PRON
admet-757	49	24	has	have	AUX
admet-757	49	25	been	be	AUX
admet-757	49	26	found	find	VERB
admet-757	49	27	that	that	SCONJ
admet-757	49	28	basic	basic	ADJ
admet-757	49	29	compounds	compound	NOUN
admet-757	49	30	that	that	PRON
admet-757	49	31	have	have	VERB
admet-757	49	32	chi	chi	NOUN
admet-757	49	33	(	(	PUNCT
admet-757	49	34	iam	iam	PROPN
admet-757	49	35	)	)	PUNCT
admet-757	49	36	value	value	NOUN
admet-757	49	37	greater	great	ADJ
admet-757	49	38	than	than	ADP
admet-757	49	39	50	50	NUM
admet-757	49	40	have	have	VERB
admet-757	49	41	phospholipidosis	phospholipidosis	NOUN
admet-757	49	42	potential	potential	NOUN
admet-757	49	43	[	[	X
admet-757	49	44	20	20	NUM
admet-757	49	45	]	]	PUNCT
admet-757	49	46	and	and	CCONJ
admet-757	49	47	also	also	ADV
admet-757	49	48	show	show	VERB
admet-757	49	49	promiscuous	promiscuous	ADJ
admet-757	49	50	binding	bind	VERB
admet-757	49	51	,	,	PUNCT
admet-757	49	52	interacting	interact	VERB
admet-757	49	53	with	with	ADP
admet-757	49	54	several	several	ADJ
admet-757	49	55	targets	target	NOUN
admet-757	49	56	,	,	PUNCT
admet-757	49	57	causing	cause	VERB
admet-757	49	58	potential	potential	ADJ
admet-757	49	59	toxicity	toxicity	NOUN
admet-757	49	60	and	and	CCONJ
admet-757	49	61	side	side	NOUN
admet-757	49	62	effects	effect	NOUN
admet-757	49	63	[	[	X
admet-757	49	64	21	21	NUM
admet-757	49	65	]	]	PUNCT
admet-757	49	66	.	.	PUNCT
admet-757	50	1	at	at	ADP
admet-757	50	2	present	present	PROPN
admet-757	50	3	regis	regis	PROPN
admet-757	50	4	technologies	technologies	PROPN
admet-757	50	5	inc	inc	PROPN
admet-757	50	6	.	.	PROPN
admet-757	50	7	(	(	PUNCT
admet-757	50	8	morton	morton	PROPN
admet-757	50	9	grove	grove	PROPN
admet-757	50	10	,	,	PUNCT
admet-757	50	11	il	il	PROPN
admet-757	50	12	,	,	PUNCT
admet-757	50	13	usa	usa	PROPN
admet-757	50	14	)	)	PUNCT
admet-757	50	15	is	be	AUX
admet-757	50	16	the	the	DET
admet-757	50	17	only	only	ADJ
admet-757	50	18	manufacturer	manufacturer	NOUN
admet-757	50	19	of	of	ADP
admet-757	50	20	the	the	DET
admet-757	50	21	immobilized	immobilized	ADJ
admet-757	50	22	artificial	artificial	ADJ
admet-757	50	23	membrane	membrane	NOUN
admet-757	50	24	(	(	PUNCT
admet-757	50	25	iam	iam	PROPN
admet-757	50	26	)	)	PUNCT
admet-757	50	27	stationary	stationary	ADJ
admet-757	50	28	phase	phase	NOUN
admet-757	50	29	.	.	PUNCT
admet-757	51	1	the	the	DET
admet-757	51	2	stationary	stationary	ADJ
admet-757	51	3	phase	phase	NOUN
admet-757	51	4	contains	contain	VERB
admet-757	51	5	only	only	ADV
admet-757	51	6	a	a	DET
admet-757	51	7	monolayer	monolayer	NOUN
admet-757	51	8	of	of	ADP
admet-757	51	9	the	the	DET
admet-757	51	10	phosphatidylcholine	phosphatidylcholine	NOUN
admet-757	51	11	(	(	PUNCT
admet-757	51	12	pc	pc	NOUN
admet-757	51	13	)	)	PUNCT
admet-757	51	14	with	with	ADP
admet-757	51	15	the	the	DET
admet-757	51	16	aliphatic	aliphatic	ADJ
admet-757	51	17	part	part	NOUN
admet-757	51	18	chemically	chemically	ADV
admet-757	51	19	bonded	bond	VERB
admet-757	51	20	to	to	ADP
admet-757	51	21	the	the	DET
admet-757	51	22	silica	silica	NOUN
admet-757	51	23	while	while	SCONJ
admet-757	51	24	the	the	DET
admet-757	51	25	choline	choline	NOUN
admet-757	51	26	polar	polar	ADJ
admet-757	51	27	head	head	NOUN
admet-757	51	28	group	group	NOUN
admet-757	51	29	faces	face	VERB
admet-757	51	30	towards	towards	ADP
admet-757	51	31	the	the	DET
admet-757	51	32	mobile	mobile	ADJ
admet-757	51	33	phase	phase	NOUN
admet-757	51	34	.	.	PUNCT
admet-757	52	1	initially	initially	ADV
admet-757	52	2	,	,	PUNCT
admet-757	52	3	“	"	PUNCT
admet-757	52	4	type	type	VERB
admet-757	52	5	a	a	DET
admet-757	52	6	”	"	PUNCT
admet-757	52	7	silica	silica	NOUN
admet-757	52	8	was	be	AUX
admet-757	52	9	used	use	VERB
admet-757	52	10	in	in	ADP
admet-757	52	11	the	the	DET
admet-757	52	12	bonding	bonding	NOUN
admet-757	52	13	procedure	procedure	NOUN
admet-757	52	14	.	.	PUNCT
admet-757	53	1	the	the	DET
admet-757	53	2	pc	pc	NOUN
admet-757	53	3	molecule	molecule	NOUN
admet-757	53	4	has	have	VERB
admet-757	53	5	only	only	ADV
admet-757	53	6	one	one	NUM
admet-757	53	7	alkyl	alkyl	NOUN
admet-757	53	8	chain	chain	NOUN
admet-757	53	9	available	available	ADJ
admet-757	53	10	with	with	ADP
admet-757	53	11	the	the	DET
admet-757	53	12	second	second	ADJ
admet-757	53	13	alkyl	alkyl	NOUN
admet-757	53	14	chain	chain	NOUN
admet-757	53	15	directly	directly	ADV
admet-757	53	16	bonded	bond	VERB
admet-757	53	17	to	to	ADP
admet-757	53	18	the	the	DET
admet-757	53	19	silica	silica	NOUN
admet-757	53	20	surface	surface	NOUN
admet-757	53	21	.	.	PUNCT
admet-757	54	1	in	in	ADP
admet-757	54	2	this	this	DET
admet-757	54	3	way	way	NOUN
admet-757	54	4	,	,	PUNCT
admet-757	54	5	a	a	DET
admet-757	54	6	denser	dense	ADJ
admet-757	54	7	bonding	bonding	NOUN
admet-757	54	8	could	could	AUX
admet-757	54	9	be	be	AUX
admet-757	54	10	achieved	achieve	VERB
admet-757	54	11	which	which	PRON
admet-757	54	12	was	be	AUX
admet-757	54	13	closer	close	ADJ
admet-757	54	14	to	to	ADP
admet-757	54	15	the	the	DET
admet-757	54	16	natural	natural	ADJ
admet-757	54	17	density	density	NOUN
admet-757	54	18	of	of	ADP
admet-757	54	19	pc	pc	NOUN
admet-757	54	20	molecules	molecule	NOUN
admet-757	54	21	on	on	ADP
admet-757	54	22	the	the	DET
admet-757	54	23	cell	cell	NOUN
admet-757	54	24	surface	surface	NOUN
admet-757	54	25	.	.	PUNCT
admet-757	55	1	however	however	ADV
admet-757	55	2	,	,	PUNCT
admet-757	55	3	in	in	ADP
admet-757	55	4	2018	2018	NUM
admet-757	55	5	the	the	DET
admet-757	55	6	company	company	NOUN
admet-757	55	7	had	have	VERB
admet-757	55	8	to	to	PART
admet-757	55	9	change	change	VERB
admet-757	55	10	the	the	DET
admet-757	55	11	base	base	NOUN
admet-757	55	12	silica	silica	NOUN
admet-757	55	13	material	material	NOUN
admet-757	55	14	to	to	ADP
admet-757	55	15	a	a	DET
admet-757	55	16	newer	new	ADJ
admet-757	55	17	“	"	PUNCT
admet-757	55	18	type	type	NOUN
admet-757	55	19	b	b	NOUN
admet-757	55	20	”	"	PUNCT
admet-757	55	21	as	as	SCONJ
admet-757	55	22	the	the	DET
admet-757	55	23	old	old	ADJ
admet-757	55	24	supply	supply	NOUN
admet-757	55	25	was	be	AUX
admet-757	55	26	no	no	ADV
admet-757	55	27	longer	long	ADV
admet-757	55	28	available	available	ADJ
admet-757	55	29	.	.	PUNCT
admet-757	56	1	“	"	PUNCT
admet-757	56	2	type	type	NOUN
admet-757	56	3	b	b	NOUN
admet-757	56	4	”	"	PUNCT
admet-757	56	5	silica	silica	NOUN
admet-757	56	6	has	have	AUX
admet-757	56	7	been	be	AUX
admet-757	56	8	chosen	choose	VERB
admet-757	56	9	as	as	ADP
admet-757	56	10	the	the	DET
admet-757	56	11	closest	close	ADJ
admet-757	56	12	in	in	ADP
admet-757	56	13	properties	property	NOUN
admet-757	56	14	to	to	PART
admet-757	56	15	“	"	PUNCT
admet-757	56	16	type	type	VERB
admet-757	56	17	a	a	PRON
admet-757	56	18	”	"	PUNCT
admet-757	56	19	regarding	regard	VERB
admet-757	56	20	the	the	DET
admet-757	56	21	specific	specific	ADJ
admet-757	56	22	surface	surface	NOUN
admet-757	56	23	area	area	NOUN
admet-757	56	24	,	,	PUNCT
admet-757	56	25	pore	pore	ADJ
admet-757	56	26	size	size	NOUN
admet-757	56	27	and	and	CCONJ
admet-757	56	28	particle	particle	NOUN
admet-757	56	29	size	size	NOUN
admet-757	56	30	.	.	PUNCT
admet-757	57	1	when	when	SCONJ
admet-757	57	2	testing	test	VERB
admet-757	57	3	the	the	DET
admet-757	57	4	retention	retention	NOUN
admet-757	57	5	selectivity	selectivity	NOUN
admet-757	57	6	of	of	ADP
admet-757	57	7	the	the	DET
admet-757	57	8	new	new	ADJ
admet-757	57	9	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	57	10	columns	column	NOUN
admet-757	57	11	which	which	PRON
admet-757	57	12	were	be	AUX
admet-757	57	13	otherwise	otherwise	ADV
admet-757	57	14	manufactured	manufacture	VERB
admet-757	57	15	in	in	ADP
admet-757	57	16	the	the	DET
admet-757	57	17	same	same	ADJ
admet-757	57	18	way	way	NOUN
admet-757	57	19	,	,	PUNCT
admet-757	57	20	differences	difference	NOUN
admet-757	57	21	were	be	AUX
admet-757	57	22	observed	observe	VERB
admet-757	57	23	towards	towards	ADP
admet-757	57	24	acidic	acidic	ADJ
admet-757	57	25	and	and	CCONJ
admet-757	57	26	basic	basic	ADJ
admet-757	57	27	molecules	molecule	NOUN
admet-757	57	28	.	.	PUNCT
admet-757	58	1	this	this	PRON
admet-757	58	2	was	be	AUX
admet-757	58	3	somewhat	somewhat	ADV
admet-757	58	4	surprising	surprising	ADJ
admet-757	58	5	as	as	SCONJ
admet-757	58	6	the	the	DET
admet-757	58	7	new	new	ADJ
admet-757	58	8	silica	silica	NOUN
admet-757	58	9	support	support	NOUN
admet-757	58	10	had	have	VERB
admet-757	58	11	identical	identical	ADJ
admet-757	58	12	physical	physical	ADJ
admet-757	58	13	specifications	specification	NOUN
admet-757	58	14	to	to	ADP
admet-757	58	15	the	the	DET
admet-757	58	16	previously	previously	ADV
admet-757	58	17	used	use	VERB
admet-757	58	18	silica	silica	NOUN
admet-757	58	19	(	(	PUNCT
admet-757	58	20	10	10	NUM
admet-757	58	21	µm	µm	ADP
admet-757	58	22	particle	particle	NOUN
admet-757	58	23	size	size	NOUN
admet-757	58	24	,	,	PUNCT
admet-757	58	25	300	300	NUM
admet-757	58	26	å	å	NOUN
admet-757	58	27	pore	pore	ADJ
admet-757	58	28	size	size	NOUN
admet-757	58	29	and	and	CCONJ
admet-757	58	30	nearly	nearly	ADV
admet-757	58	31	identical	identical	ADJ
admet-757	58	32	surface	surface	NOUN
admet-757	58	33	area	area	NOUN
admet-757	58	34	)	)	PUNCT
admet-757	58	35	.	.	PUNCT
admet-757	59	1	however	however	ADV
admet-757	59	2	,	,	PUNCT
admet-757	59	3	given	give	VERB
admet-757	59	4	the	the	DET
admet-757	59	5	newer	new	ADJ
admet-757	59	6	silica	silica	NOUN
admet-757	59	7	is	be	AUX
admet-757	59	8	of	of	ADP
admet-757	59	9	a	a	DET
admet-757	59	10	much	much	ADV
admet-757	59	11	higher	high	ADJ
admet-757	59	12	purity	purity	NOUN
admet-757	59	13	with	with	ADP
admet-757	59	14	only	only	ADJ
admet-757	59	15	single	single	ADJ
admet-757	59	16	ppm	ppm	NOUN
admet-757	59	17	metal	metal	NOUN
admet-757	59	18	content	content	NOUN
admet-757	59	19	,	,	PUNCT
admet-757	59	20	these	these	DET
admet-757	59	21	observations	observation	NOUN
admet-757	59	22	are	be	AUX
admet-757	59	23	understandable	understandable	ADJ
admet-757	59	24	as	as	SCONJ
admet-757	59	25	the	the	DET
admet-757	59	26	new	new	ADJ
admet-757	59	27	silica	silica	NOUN
admet-757	59	28	provides	provide	VERB
admet-757	59	29	a	a	DET
admet-757	59	30	much	much	ADV
admet-757	59	31	more	more	ADJ
admet-757	59	32	inert	inert	ADJ
admet-757	59	33	surface	surface	NOUN
admet-757	59	34	and	and	CCONJ
admet-757	59	35	likely	likely	ADV
admet-757	59	36	contributes	contribute	VERB
admet-757	59	37	to	to	ADP
admet-757	59	38	less	less	ADJ
admet-757	59	39	non	non	ADJ
admet-757	59	40	-	-	ADJ
admet-757	59	41	specific	specific	ADJ
admet-757	59	42	binding	binding	ADJ
admet-757	59	43	interactions	interaction	NOUN
admet-757	59	44	.	.	PUNCT
admet-757	60	1	the	the	DET
admet-757	60	2	difference	difference	NOUN
admet-757	60	3	in	in	ADP
admet-757	60	4	selectivity	selectivity	NOUN
admet-757	60	5	can	can	AUX
admet-757	60	6	also	also	ADV
admet-757	60	7	be	be	AUX
admet-757	60	8	attributed	attribute	VERB
admet-757	60	9	to	to	ADP
admet-757	60	10	the	the	DET
admet-757	60	11	different	different	ADJ
admet-757	60	12	arrangements	arrangement	NOUN
admet-757	60	13	of	of	ADP
admet-757	60	14	the	the	DET
admet-757	60	15	positive	positive	ADJ
admet-757	60	16	and	and	CCONJ
admet-757	60	17	negative	negative	ADJ
admet-757	60	18	charges	charge	NOUN
admet-757	60	19	of	of	ADP
admet-757	60	20	the	the	DET
admet-757	60	21	choline	choline	NOUN
admet-757	60	22	headgroup	headgroup	NOUN
admet-757	60	23	on	on	ADP
admet-757	60	24	the	the	DET
admet-757	60	25	stationary	stationary	ADJ
admet-757	60	26	phase	phase	NOUN
admet-757	60	27	surface	surface	NOUN
admet-757	60	28	,	,	PUNCT
admet-757	60	29	again	again	ADV
admet-757	60	30	somewhat	somewhat	ADV
admet-757	60	31	affected	affect	VERB
admet-757	60	32	by	by	ADP
admet-757	60	33	the	the	DET
admet-757	60	34	higher	high	ADJ
admet-757	60	35	purity	purity	NOUN
admet-757	60	36	silica	silica	NOUN
admet-757	60	37	during	during	ADP
admet-757	60	38	the	the	DET
admet-757	60	39	bonding	bonding	NOUN
admet-757	60	40	process	process	NOUN
admet-757	60	41	.	.	PUNCT
admet-757	61	1	the	the	DET
admet-757	61	2	new	new	ADJ
admet-757	61	3	batches	batch	NOUN
admet-757	61	4	of	of	ADP
admet-757	61	5	columns	column	NOUN
admet-757	61	6	did	do	AUX
admet-757	61	7	not	not	PART
admet-757	61	8	pass	pass	VERB
admet-757	61	9	the	the	DET
admet-757	61	10	original	original	ADJ
admet-757	61	11	system	system	NOUN
admet-757	61	12	suitability	suitability	NOUN
admet-757	61	13	test	test	NOUN
admet-757	61	14	criteria	criterion	NOUN
admet-757	61	15	.	.	PUNCT
admet-757	62	1	hence	hence	ADV
admet-757	62	2	the	the	DET
admet-757	62	3	aim	aim	NOUN
admet-757	62	4	was	be	AUX
admet-757	62	5	to	to	PART
admet-757	62	6	establish	establish	VERB
admet-757	62	7	new	new	ADJ
admet-757	62	8	chi	chi	NOUN
admet-757	62	9	(	(	PUNCT
admet-757	62	10	iam	iam	PROPN
admet-757	62	11	)	)	PUNCT
admet-757	62	12	values	value	NOUN
admet-757	62	13	for	for	ADP
admet-757	62	14	the	the	DET
admet-757	62	15	system	system	NOUN
admet-757	62	16	suitability	suitability	NOUN
admet-757	62	17	test	test	NOUN
admet-757	62	18	compounds	compound	VERB
admet-757	62	19	that	that	PRON
admet-757	62	20	could	could	AUX
admet-757	62	21	be	be	AUX
admet-757	62	22	reproduced	reproduce	VERB
admet-757	62	23	on	on	ADP
admet-757	62	24	the	the	DET
admet-757	62	25	new	new	ADJ
admet-757	62	26	batches	batch	NOUN
admet-757	62	27	of	of	ADP
admet-757	62	28	iam	iam	PROPN
admet-757	62	29	columns	column	NOUN
admet-757	62	30	.	.	PUNCT
admet-757	63	1	in	in	ADP
admet-757	63	2	this	this	DET
admet-757	63	3	paper	paper	NOUN
admet-757	63	4	,	,	PUNCT
admet-757	63	5	the	the	DET
admet-757	63	6	investigation	investigation	NOUN
admet-757	63	7	of	of	ADP
admet-757	63	8	the	the	DET
admet-757	63	9	selectivity	selectivity	NOUN
admet-757	63	10	difference	difference	NOUN
admet-757	63	11	is	be	AUX
admet-757	63	12	reported	report	VERB
admet-757	63	13	using	use	VERB
admet-757	63	14	over	over	ADP
admet-757	63	15	70	70	NUM
admet-757	63	16	marketed	market	VERB
admet-757	63	17	drug	drug	NOUN
admet-757	63	18	molecules	molecule	NOUN
admet-757	63	19	and	and	CCONJ
admet-757	63	20	the	the	DET
admet-757	63	21	in	in	ADP
admet-757	63	22	vivo	vivo	ADJ
admet-757	63	23	distribution	distribution	NOUN
admet-757	63	24	models	model	NOUN
admet-757	63	25	are	be	AUX
admet-757	63	26	compared	compare	VERB
admet-757	63	27	for	for	ADP
admet-757	63	28	the	the	DET
admet-757	63	29	old	old	ADJ
admet-757	63	30	and	and	CCONJ
admet-757	63	31	the	the	DET
admet-757	63	32	new	new	ADJ
admet-757	63	33	batches	batch	NOUN
admet-757	63	34	of	of	ADP
admet-757	63	35	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	63	36	stationary	stationary	ADJ
admet-757	63	37	phases	phase	NOUN
admet-757	63	38	.	.	PUNCT
admet-757	64	1	the	the	DET
admet-757	64	2	estimated	estimate	VERB
admet-757	64	3	volume	volume	NOUN
admet-757	64	4	of	of	ADP
admet-757	64	5	distribution	distribution	NOUN
admet-757	64	6	data	datum	NOUN
admet-757	64	7	was	be	AUX
admet-757	64	8	compared	compare	VERB
admet-757	64	9	with	with	ADP
admet-757	64	10	the	the	DET
admet-757	64	11	data	datum	NOUN
admet-757	64	12	from	from	ADP
admet-757	64	13	the	the	DET
admet-757	64	14	previously	previously	ADV
admet-757	64	15	published	publish	VERB
admet-757	64	16	models	model	NOUN
admet-757	64	17	.	.	PUNCT
admet-757	65	1	the	the	DET
admet-757	65	2	differences	difference	NOUN
admet-757	65	3	of	of	ADP
admet-757	65	4	the	the	DET
admet-757	65	5	models	model	NOUN
admet-757	65	6	for	for	ADP
admet-757	65	7	the	the	DET
admet-757	65	8	estimated	estimate	VERB
admet-757	65	9	brain	brain	NOUN
admet-757	65	10	tissue	tissue	NOUN
admet-757	65	11	binding	bind	VERB
admet-757	65	12	and	and	CCONJ
admet-757	65	13	drug	drug	NOUN
admet-757	65	14	efficiency	efficiency	NOUN
admet-757	65	15	values	value	NOUN
admet-757	65	16	of	of	ADP
admet-757	65	17	the	the	DET
admet-757	65	18	known	know	VERB
admet-757	65	19	drug	drug	NOUN
admet-757	65	20	molecules	molecule	NOUN
admet-757	65	21	are	be	AUX
admet-757	65	22	investigated	investigate	VERB
admet-757	65	23	and	and	CCONJ
admet-757	65	24	compared	compare	VERB
admet-757	65	25	with	with	ADP
admet-757	65	26	the	the	DET
admet-757	65	27	published	publish	VERB
admet-757	65	28	data	datum	NOUN
admet-757	65	29	obtained	obtain	VERB
admet-757	65	30	using	use	VERB
admet-757	65	31	the	the	DET
admet-757	65	32	previous	previous	ADJ
admet-757	65	33	batches	batch	NOUN
admet-757	65	34	of	of	ADP
admet-757	65	35	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	65	36	columns	column	NOUN
admet-757	65	37	.	.	PUNCT
admet-757	66	1	experimental	experimental	ADJ
admet-757	66	2	all	all	DET
admet-757	66	3	high	high	ADJ
admet-757	66	4	-	-	PUNCT
admet-757	66	5	performance	performance	NOUN
admet-757	66	6	liquid	liquid	ADJ
admet-757	66	7	chromatography	chromatography	NOUN
admet-757	66	8	measurements	measurement	NOUN
admet-757	66	9	were	be	AUX
admet-757	66	10	performed	perform	VERB
admet-757	66	11	on	on	ADP
admet-757	66	12	an	an	DET
admet-757	66	13	agilent	agilent	PROPN
admet-757	66	14	1100	1100	NUM
admet-757	66	15	series	series	PROPN
admet-757	66	16	hplc	hplc	PROPN
admet-757	66	17	instrument	instrument	PROPN
admet-757	66	18	equipped	equip	VERB
admet-757	66	19	with	with	ADP
admet-757	66	20	an	an	DET
admet-757	66	21	ultraviolet	ultraviolet	ADJ
admet-757	66	22	diode	diode	NOUN
admet-757	66	23	array	array	NOUN
admet-757	66	24	detector	detector	NOUN
admet-757	66	25	(	(	PUNCT
admet-757	66	26	dad	dad	NOUN
admet-757	66	27	)	)	PUNCT
admet-757	66	28	.	.	PUNCT
admet-757	67	1	measurements	measurement	NOUN
admet-757	67	2	of	of	ADP
admet-757	67	3	membrane	membrane	NOUN
admet-757	67	4	binding	binding	NOUN
admet-757	67	5	using	use	VERB
admet-757	67	6	immobilized	immobilized	ADJ
admet-757	67	7	artificial	artificial	ADJ
admet-757	67	8	membrane	membrane	NOUN
admet-757	67	9	(	(	PUNCT
admet-757	67	10	iam	iam	PROPN
admet-757	67	11	)	)	PUNCT
admet-757	67	12	chromatography	chromatography	NOUN
admet-757	67	13	the	the	DET
admet-757	67	14	iam	iam	PROPN
admet-757	67	15	binding	bind	VERB
admet-757	67	16	was	be	AUX
admet-757	67	17	measured	measure	VERB
admet-757	67	18	using	use	VERB
admet-757	67	19	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	67	20	hplc	hplc	NOUN
admet-757	67	21	columns	column	NOUN
admet-757	67	22	(	(	PUNCT
admet-757	67	23	regis	regis	PROPN
admet-757	67	24	technologies	technologies	PROPN
admet-757	67	25	,	,	PUNCT
admet-757	67	26	inc	inc	PROPN
admet-757	67	27	.	.	PROPN
admet-757	67	28	,	,	PUNCT
admet-757	67	29	il	il	PROPN
admet-757	67	30	,	,	PUNCT
admet-757	67	31	usa	usa	PROPN
admet-757	67	32	)	)	PUNCT
admet-757	67	33	with	with	ADP
admet-757	67	34	dimensions	dimension	NOUN
admet-757	67	35	of	of	ADP
admet-757	67	36	100	100	NUM
admet-757	67	37	x	x	SYM
admet-757	67	38	4.6	4.6	NUM
admet-757	67	39	mm	mm	NOUN
admet-757	67	40	,	,	PUNCT
admet-757	67	41	particle	particle	NOUN
admet-757	67	42	size	size	NOUN
admet-757	67	43	10	10	NUM
admet-757	67	44	µm	µm	NOUN
admet-757	67	45	with	with	ADP
admet-757	67	46	300	300	NUM
admet-757	67	47	å	å	PRON
admet-757	67	48	pore	pore	ADJ
admet-757	67	49	size	size	NOUN
admet-757	67	50	.	.	PUNCT
admet-757	68	1	two	two	NUM
admet-757	68	2	batches	batch	NOUN
admet-757	68	3	of	of	ADP
admet-757	68	4	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	68	5	columns	column	NOUN
admet-757	68	6	were	be	AUX
admet-757	68	7	studied	study	VERB
admet-757	68	8	(	(	PUNCT
admet-757	68	9	r20511	r20511	NUM
admet-757	68	10	-	-	PUNCT
admet-757	68	11	014	014	NUM
admet-757	68	12	-	-	PUNCT
admet-757	68	13	3	3	NUM
admet-757	68	14	and	and	CCONJ
admet-757	68	15	p20511	p20511	NOUN
admet-757	68	16	-	-	PUNCT
admet-757	68	17	014	014	NUM
admet-757	68	18	-	-	PUNCT
admet-757	68	19	3	3	NUM
admet-757	68	20	)	)	PUNCT
admet-757	68	21	that	that	PRON
admet-757	68	22	had	have	AUX
admet-757	68	23	been	be	AUX
admet-757	68	24	admet	admet	PROPN
admet-757	68	25	&	&	CCONJ
admet-757	68	26	dmpk	dmpk	PROPN
admet-757	68	27	8(1	8(1	NOUN
admet-757	68	28	)	)	PUNCT
admet-757	68	29	(	(	PUNCT
admet-757	68	30	2020	2020	NUM
admet-757	68	31	)	)	PUNCT
admet-757	68	32	78	78	NUM
admet-757	68	33	-	-	SYM
admet-757	68	34	97	97	NUM
admet-757	68	35	revisiting	revisit	VERB
admet-757	68	36	the	the	DET
admet-757	68	37	iam	iam	PROPN
admet-757	68	38	chromatography	chromatography	NOUN
admet-757	68	39	doi	doi	PROPN
admet-757	68	40	:	:	PUNCT
admet-757	68	41	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	68	42	81	81	NUM
admet-757	68	43	prepared	prepared	ADJ
admet-757	68	44	using	use	VERB
admet-757	68	45	the	the	DET
admet-757	68	46	new	new	ADJ
admet-757	68	47	batches	batch	NOUN
admet-757	68	48	of	of	ADP
admet-757	68	49	silica	silica	NOUN
admet-757	68	50	support	support	NOUN
admet-757	68	51	.	.	PUNCT
admet-757	69	1	the	the	DET
admet-757	69	2	selectivity	selectivity	NOUN
admet-757	69	3	and	and	CCONJ
admet-757	69	4	the	the	DET
admet-757	69	5	models	model	NOUN
admet-757	69	6	obtained	obtain	VERB
admet-757	69	7	were	be	AUX
admet-757	69	8	compared	compare	VERB
admet-757	69	9	with	with	ADP
admet-757	69	10	the	the	DET
admet-757	69	11	published	publish	VERB
admet-757	69	12	average	average	NOUN
admet-757	69	13	iam	iam	PROPN
admet-757	69	14	data	datum	NOUN
admet-757	69	15	obtained	obtain	VERB
admet-757	69	16	on	on	ADP
admet-757	69	17	the	the	DET
admet-757	69	18	columns	column	NOUN
admet-757	69	19	manufactured	manufacture	VERB
admet-757	69	20	between	between	ADP
admet-757	69	21	2004	2004	NUM
admet-757	69	22	and	and	CCONJ
admet-757	69	23	2012	2012	NUM
admet-757	69	24	[	[	X
admet-757	69	25	14	14	NUM
admet-757	69	26	]	]	PUNCT
admet-757	69	27	.	.	PUNCT
admet-757	70	1	mobile	mobile	ADJ
admet-757	70	2	phase	phase	NOUN
admet-757	70	3	a	a	PRON
admet-757	70	4	was	be	AUX
admet-757	70	5	50	50	NUM
admet-757	70	6	mm	mm	NOUN
admet-757	70	7	ammonium	ammonium	NOUN
admet-757	70	8	acetate	acetate	NOUN
admet-757	70	9	adjusted	adjust	VERB
admet-757	70	10	to	to	ADP
admet-757	70	11	ph	ph	PROPN
admet-757	70	12	7.4	7.4	NUM
admet-757	70	13	and	and	CCONJ
admet-757	70	14	mobile	mobile	ADJ
admet-757	70	15	phase	phase	NOUN
admet-757	70	16	b	b	NOUN
admet-757	70	17	was	be	AUX
admet-757	70	18	100	100	NUM
admet-757	70	19	%	%	NOUN
admet-757	70	20	acetonitrile	acetonitrile	NOUN
admet-757	70	21	.	.	PUNCT
admet-757	71	1	the	the	DET
admet-757	71	2	mobile	mobile	ADJ
admet-757	71	3	phase	phase	NOUN
admet-757	71	4	flow	flow	NOUN
admet-757	71	5	rate	rate	NOUN
admet-757	71	6	was	be	AUX
admet-757	71	7	1.5	1.5	NUM
admet-757	71	8	ml	ml	NOUN
admet-757	71	9	/	/	SYM
admet-757	71	10	min	min	NOUN
admet-757	71	11	and	and	CCONJ
admet-757	71	12	the	the	DET
admet-757	71	13	run	run	NOUN
admet-757	71	14	time	time	NOUN
admet-757	71	15	was	be	AUX
admet-757	71	16	6	6	NUM
admet-757	71	17	min	min	NOUN
admet-757	71	18	.	.	PUNCT
admet-757	72	1	the	the	DET
admet-757	72	2	acetonitrile	acetonitrile	ADJ
admet-757	72	3	gradient	gradient	NOUN
admet-757	72	4	was	be	AUX
admet-757	72	5	applied	apply	VERB
admet-757	72	6	from	from	ADP
admet-757	72	7	0	0	NUM
admet-757	72	8	to	to	ADP
admet-757	72	9	85	85	NUM
admet-757	72	10	%	%	NOUN
admet-757	72	11	from	from	ADP
admet-757	72	12	0	0	NUM
admet-757	72	13	to	to	ADP
admet-757	72	14	4.75	4.75	NUM
admet-757	72	15	min	min	NOUN
admet-757	72	16	and	and	CCONJ
admet-757	72	17	kept	keep	VERB
admet-757	72	18	at	at	ADP
admet-757	72	19	85	85	NUM
admet-757	72	20	%	%	NOUN
admet-757	72	21	until	until	ADP
admet-757	72	22	5.15	5.15	NUM
admet-757	72	23	min	min	NOUN
admet-757	72	24	.	.	PROPN
admet-757	72	25	from	from	ADP
admet-757	72	26	5.15	5.15	NUM
admet-757	72	27	to	to	ADP
admet-757	72	28	5.25	5.25	NUM
admet-757	72	29	min	min	NOUN
admet-757	72	30	the	the	DET
admet-757	72	31	acetonitrile	acetonitrile	ADJ
admet-757	72	32	concentration	concentration	NOUN
admet-757	72	33	dropped	drop	VERB
admet-757	72	34	back	back	ADV
admet-757	72	35	to	to	ADP
admet-757	72	36	0	0	NUM
admet-757	72	37	%	%	NOUN
admet-757	72	38	.	.	PUNCT
admet-757	73	1	the	the	DET
admet-757	73	2	retention	retention	NOUN
admet-757	73	3	times	time	NOUN
admet-757	73	4	were	be	AUX
admet-757	73	5	standardized	standardize	VERB
admet-757	73	6	using	use	VERB
admet-757	73	7	the	the	DET
admet-757	73	8	iam	iam	PROPN
admet-757	73	9	calibration	calibration	NOUN
admet-757	73	10	mixture	mixture	NOUN
admet-757	73	11	,	,	PUNCT
admet-757	73	12	containing	contain	VERB
admet-757	73	13	octanophenone	octanophenone	NOUN
admet-757	73	14	,	,	PUNCT
admet-757	73	15	heptanophenone	heptanophenone	NOUN
admet-757	73	16	,	,	PUNCT
admet-757	73	17	hexanophenone	hexanophenone	NOUN
admet-757	73	18	,	,	PUNCT
admet-757	73	19	valerophenone	valerophenone	NOUN
admet-757	73	20	,	,	PUNCT
admet-757	73	21	butyrophenone	butyrophenone	NOUN
admet-757	73	22	,	,	PUNCT
admet-757	73	23	propiophenone	propiophenone	NOUN
admet-757	73	24	,	,	PUNCT
admet-757	73	25	acetophenone	acetophenone	PROPN
admet-757	73	26	,	,	PUNCT
admet-757	73	27	acetanilide	acetanilide	ADJ
admet-757	73	28	and	and	CCONJ
admet-757	73	29	paracetamol	paracetamol	NOUN
admet-757	73	30	.	.	PUNCT
admet-757	74	1	the	the	DET
admet-757	74	2	retention	retention	NOUN
admet-757	74	3	times	time	NOUN
admet-757	74	4	of	of	ADP
admet-757	74	5	the	the	DET
admet-757	74	6	compounds	compound	NOUN
admet-757	74	7	were	be	AUX
admet-757	74	8	plotted	plot	VERB
admet-757	74	9	against	against	ADP
admet-757	74	10	the	the	DET
admet-757	74	11	isocratically	isocratically	ADV
admet-757	74	12	determined	determine	VERB
admet-757	74	13	and	and	CCONJ
admet-757	74	14	predefined	predefine	VERB
admet-757	74	15	chi	chi	NOUN
admet-757	74	16	(	(	PUNCT
admet-757	74	17	iam	iam	PROPN
admet-757	74	18	)	)	PUNCT
admet-757	74	19	values	value	NOUN
admet-757	74	20	[	[	X
admet-757	74	21	4	4	X
admet-757	74	22	]	]	PUNCT
admet-757	74	23	listed	list	VERB
admet-757	74	24	in	in	ADP
admet-757	74	25	table	table	NOUN
admet-757	74	26	1	1	NUM
admet-757	74	27	.	.	PUNCT
admet-757	75	1	the	the	DET
admet-757	75	2	slope	slope	NOUN
admet-757	75	3	and	and	CCONJ
admet-757	75	4	intercept	intercept	NOUN
admet-757	75	5	of	of	ADP
admet-757	75	6	the	the	DET
admet-757	75	7	obtained	obtain	VERB
admet-757	75	8	straight	straight	ADJ
admet-757	75	9	line	line	NOUN
admet-757	75	10	was	be	AUX
admet-757	75	11	used	use	VERB
admet-757	75	12	to	to	PART
admet-757	75	13	calculate	calculate	VERB
admet-757	75	14	the	the	DET
admet-757	75	15	chi	chi	PROPN
admet-757	75	16	iam	iam	PROPN
admet-757	75	17	values	value	NOUN
admet-757	75	18	of	of	ADP
admet-757	75	19	new	new	ADJ
admet-757	75	20	compounds	compound	NOUN
admet-757	75	21	.	.	PUNCT
admet-757	76	1	the	the	DET
admet-757	76	2	chi	chi	PROPN
admet-757	76	3	iam	iam	PROPN
admet-757	76	4	values	value	NOUN
admet-757	76	5	were	be	AUX
admet-757	76	6	converted	convert	VERB
admet-757	76	7	to	to	ADP
admet-757	76	8	the	the	DET
admet-757	76	9	octanol	octanol	NOUN
admet-757	76	10	/	/	SYM
admet-757	76	11	water	water	NOUN
admet-757	76	12	lipophilicity	lipophilicity	NOUN
admet-757	76	13	scale	scale	NOUN
admet-757	76	14	and	and	CCONJ
admet-757	76	15	expressed	express	VERB
admet-757	76	16	as	as	ADP
admet-757	76	17	log	log	PROPN
admet-757	76	18	k	k	PROPN
admet-757	76	19	(	(	PUNCT
admet-757	76	20	iam	iam	PROPN
admet-757	76	21	)	)	PUNCT
admet-757	76	22	values	value	NOUN
admet-757	76	23	using	use	VERB
admet-757	76	24	equation	equation	NOUN
admet-757	76	25	(	(	PUNCT
admet-757	76	26	7	7	NUM
admet-757	76	27	)	)	PUNCT
admet-757	76	28	.	.	PUNCT
admet-757	77	1	log	log	VERB
admet-757	77	2	k	k	PROPN
admet-757	77	3	(	(	PUNCT
admet-757	77	4	iam	iam	PROPN
admet-757	77	5	)	)	PUNCT
admet-757	77	6	=	=	SYM
admet-757	78	1	0.29	0.29	NUM
admet-757	78	2	exp(0.026	exp(0.026	PROPN
admet-757	78	3	chi	chi	PROPN
admet-757	78	4	(	(	PUNCT
admet-757	78	5	iam	iam	PROPN
admet-757	78	6	)	)	PUNCT
admet-757	78	7	+	+	CCONJ
admet-757	78	8	0.70	0.70	NUM
admet-757	78	9	(	(	PUNCT
admet-757	78	10	7	7	NUM
admet-757	78	11	)	)	PUNCT
admet-757	78	12	the	the	DET
admet-757	78	13	so	so	ADV
admet-757	78	14	-	-	PUNCT
admet-757	78	15	obtained	obtain	VERB
admet-757	78	16	log	log	NOUN
admet-757	78	17	kiam	kiam	PROPN
admet-757	78	18	values	value	NOUN
admet-757	78	19	express	express	VERB
admet-757	78	20	the	the	DET
admet-757	78	21	membrane	membrane	NOUN
admet-757	78	22	partition	partition	NOUN
admet-757	78	23	comparable	comparable	ADJ
admet-757	78	24	to	to	ADP
admet-757	78	25	the	the	DET
admet-757	78	26	octanol	octanol	NOUN
admet-757	78	27	/	/	SYM
admet-757	78	28	water	water	NOUN
admet-757	78	29	lipophilicity	lipophilicity	NOUN
admet-757	78	30	as	as	SCONJ
admet-757	78	31	described	describe	VERB
admet-757	78	32	in	in	ADP
admet-757	78	33	reference	reference	NOUN
admet-757	78	34	[	[	X
admet-757	78	35	22	22	NUM
admet-757	78	36	]	]	PUNCT
admet-757	78	37	.	.	PUNCT
admet-757	79	1	a	a	DET
admet-757	79	2	typical	typical	ADJ
admet-757	79	3	chromatogram	chromatogram	NOUN
admet-757	79	4	is	be	AUX
admet-757	79	5	shown	show	VERB
admet-757	79	6	in	in	ADP
admet-757	79	7	figure	figure	NOUN
admet-757	79	8	1	1	NUM
admet-757	79	9	.	.	PUNCT
admet-757	79	10	figure	figure	NOUN
admet-757	79	11	1	1	NUM
admet-757	79	12	.	.	PUNCT
admet-757	80	1	a	a	DET
admet-757	80	2	typical	typical	ADJ
admet-757	80	3	chromatogram	chromatogram	NOUN
admet-757	80	4	obtained	obtain	VERB
admet-757	80	5	on	on	ADP
admet-757	80	6	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	80	7	100	100	NUM
admet-757	80	8	x	x	SYM
admet-757	80	9	4.6	4.6	NUM
admet-757	80	10	mm	mm	NOUN
admet-757	80	11	hplc	hplc	NOUN
admet-757	80	12	column	column	NOUN
admet-757	80	13	.	.	PUNCT
admet-757	81	1	flow	flow	NOUN
admet-757	81	2	rate	rate	NOUN
admet-757	81	3	:	:	PUNCT
admet-757	81	4	1.5	1.5	NUM
admet-757	81	5	ml	ml	NOUN
admet-757	81	6	/	/	SYM
admet-757	81	7	min	min	NOUN
admet-757	81	8	;	;	PUNCT
admet-757	81	9	mobile	mobile	ADJ
admet-757	81	10	phase	phase	NOUN
admet-757	81	11	a	a	DET
admet-757	81	12	:	:	SYM
admet-757	81	13	50	50	NUM
admet-757	81	14	mm	mm	NOUN
admet-757	81	15	ammonium	ammonium	NOUN
admet-757	81	16	acetate	acetate	NOUN
admet-757	81	17	adjusted	adjust	VERB
admet-757	81	18	to	to	ADP
admet-757	81	19	ph	ph	ADJ
admet-757	81	20	7.4	7.4	NUM
admet-757	81	21	,	,	PUNCT
admet-757	81	22	mobile	mobile	ADJ
admet-757	81	23	phaseb	phaseb	NOUN
admet-757	81	24	:	:	PUNCT
admet-757	81	25	acetonitrile	acetonitrile	PROPN
admet-757	81	26	.	.	PUNCT
admet-757	82	1	run	run	VERB
admet-757	82	2	time	time	NOUN
admet-757	82	3	6	6	NUM
admet-757	82	4	min	min	NOUN
admet-757	82	5	;	;	PUNCT
admet-757	82	6	gradient	gradient	NOUN
admet-757	82	7	:	:	PUNCT
admet-757	82	8	0	0	NUM
admet-757	82	9	to	to	ADP
admet-757	82	10	4.75	4.75	NUM
admet-757	82	11	min	min	NOUN
admet-757	82	12	0	0	NUM
admet-757	82	13	to	to	ADP
admet-757	82	14	85	85	NUM
admet-757	82	15	%	%	NOUN
admet-757	82	16	b	b	NOUN
admet-757	82	17	,	,	PUNCT
admet-757	82	18	4.75	4.75	NUM
admet-757	82	19	to	to	ADP
admet-757	82	20	5.15	5.15	NUM
admet-757	82	21	min	min	NOUN
admet-757	82	22	85	85	NUM
admet-757	82	23	%	%	NOUN
admet-757	82	24	b	b	NOUN
admet-757	82	25	,	,	PUNCT
admet-757	82	26	5.15	5.15	NUM
admet-757	82	27	to	to	PART
admet-757	82	28	5.25	5.25	NUM
admet-757	82	29	min	min	NOUN
admet-757	82	30	0	0	NUM
admet-757	82	31	%	%	NOUN
admet-757	82	32	b	b	NOUN
admet-757	82	33	;	;	PUNCT
admet-757	82	34	detection	detection	NOUN
admet-757	82	35	wavelength	wavelength	NOUN
admet-757	82	36	:	:	PUNCT
admet-757	82	37	250	250	NUM
admet-757	82	38	nm	nm	VERB
admet-757	82	39	the	the	DET
admet-757	82	40	natural	natural	ADJ
admet-757	82	41	state	state	NOUN
admet-757	82	42	of	of	ADP
admet-757	82	43	the	the	DET
admet-757	82	44	phosphatidylcholine	phosphatidylcholine	NOUN
admet-757	82	45	headgroup	headgroup	NOUN
admet-757	82	46	on	on	ADP
admet-757	82	47	the	the	DET
admet-757	82	48	iam	iam	PROPN
admet-757	82	49	stationary	stationary	ADJ
admet-757	82	50	phase	phase	NOUN
admet-757	82	51	provides	provide	VERB
admet-757	82	52	the	the	DET
admet-757	82	53	column	column	NOUN
admet-757	82	54	selectivity	selectivity	NOUN
admet-757	82	55	that	that	PRON
admet-757	82	56	was	be	AUX
admet-757	82	57	tested	test	VERB
admet-757	82	58	using	use	VERB
admet-757	82	59	the	the	DET
admet-757	82	60	system	system	NOUN
admet-757	82	61	suitability	suitability	NOUN
admet-757	82	62	test	test	NOUN
admet-757	82	63	compounds	compound	NOUN
admet-757	82	64	containing	contain	VERB
admet-757	82	65	acidic	acidic	ADJ
admet-757	82	66	,	,	PUNCT
admet-757	82	67	basic	basic	ADJ
admet-757	82	68	and	and	CCONJ
admet-757	82	69	neutral	neutral	ADJ
admet-757	82	70	compounds	compound	NOUN
admet-757	82	71	.	.	PUNCT
admet-757	83	1	protein	protein	NOUN
admet-757	83	2	binding	bind	VERB
admet-757	83	3	measurements	measurement	NOUN
admet-757	83	4	using	use	VERB
admet-757	83	5	biomimetic	biomimetic	ADJ
admet-757	83	6	protein	protein	NOUN
admet-757	83	7	stationary	stationary	ADJ
admet-757	83	8	phases	phase	NOUN
admet-757	83	9	the	the	DET
admet-757	83	10	interaction	interaction	NOUN
admet-757	83	11	of	of	ADP
admet-757	83	12	the	the	DET
admet-757	83	13	compounds	compound	NOUN
admet-757	83	14	listed	list	VERB
admet-757	83	15	in	in	ADP
admet-757	83	16	table	table	NOUN
admet-757	83	17	2	2	NUM
admet-757	83	18	with	with	ADP
admet-757	83	19	human	human	ADJ
admet-757	83	20	serum	serum	NOUN
admet-757	83	21	albumin	albumin	PROPN
admet-757	83	22	(	(	PUNCT
admet-757	83	23	hsa	hsa	PROPN
admet-757	83	24	)	)	PUNCT
admet-757	83	25	has	have	AUX
admet-757	83	26	been	be	AUX
admet-757	83	27	measured	measure	VERB
admet-757	83	28	using	use	VERB
admet-757	83	29	commercially	commercially	ADV
admet-757	83	30	available	available	ADJ
admet-757	83	31	chemically	chemically	ADV
admet-757	83	32	bonded	bond	VERB
admet-757	83	33	hsa	hsa	PROPN
admet-757	83	34	columns	column	NOUN
admet-757	83	35	(	(	PUNCT
admet-757	83	36	chiralpak	chiralpak	VERB
admet-757	83	37	-	-	PUNCT
admet-757	83	38	hsa	hsa	PROPN
admet-757	83	39	from	from	ADP
admet-757	83	40	hichrom	hichrom	ADP
admet-757	83	41	,	,	PUNCT
admet-757	83	42	uk	uk	PROPN
admet-757	83	43	)	)	PUNCT
admet-757	83	44	with	with	ADP
admet-757	83	45	the	the	DET
admet-757	83	46	dimensions	dimension	NOUN
admet-757	83	47	of	of	ADP
admet-757	83	48	50	50	NUM
admet-757	83	49	x	x	SYM
admet-757	83	50	3	3	NUM
admet-757	83	51	mm	mm	NOUN
admet-757	83	52	and	and	CCONJ
admet-757	83	53	a	a	DET
admet-757	83	54	particle	particle	NOUN
admet-757	83	55	size	size	NOUN
admet-757	83	56	of	of	ADP
admet-757	83	57	5	5	NUM
admet-757	83	58	μm	μm	NOUN
admet-757	83	59	.	.	PUNCT
admet-757	84	1	mobile	mobile	ADJ
admet-757	84	2	phase	phase	NOUN
admet-757	84	3	a	a	PRON
admet-757	84	4	was	be	AUX
admet-757	84	5	50	50	NUM
admet-757	84	6	mm	mm	NOUN
admet-757	84	7	ammonium	ammonium	NOUN
admet-757	84	8	acetate	acetate	NOUN
admet-757	84	9	adjusted	adjust	VERB
admet-757	84	10	to	to	ADP
admet-757	84	11	ph	ph	PROPN
admet-757	84	12	7.4	7.4	NUM
admet-757	84	13	and	and	CCONJ
admet-757	84	14	mobile	mobile	ADJ
admet-757	84	15	phase	phase	NOUN
admet-757	84	16	b	b	NOUN
admet-757	84	17	was	be	AUX
admet-757	84	18	2	2	NUM
admet-757	84	19	-	-	PUNCT
admet-757	84	20	propanol	propanol	NOUN
admet-757	84	21	.	.	PUNCT
admet-757	85	1	the	the	DET
admet-757	85	2	flow	flow	NOUN
admet-757	85	3	rate	rate	NOUN
admet-757	85	4	was	be	AUX
admet-757	85	5	1.5	1.5	NUM
admet-757	85	6	ml	ml	NOUN
admet-757	85	7	/	/	SYM
admet-757	85	8	min	min	NOUN
admet-757	85	9	and	and	CCONJ
admet-757	85	10	the	the	DET
admet-757	85	11	run	run	NOUN
admet-757	85	12	time	time	NOUN
admet-757	85	13	was	be	AUX
admet-757	85	14	6	6	NUM
admet-757	85	15	min	min	NOUN
admet-757	85	16	.	.	PUNCT
admet-757	86	1	the	the	DET
admet-757	86	2	2	2	NUM
admet-757	86	3	-	-	PUNCT
admet-757	86	4	propanol	propanol	ADJ
admet-757	86	5	gradient	gradient	NOUN
admet-757	86	6	was	be	AUX
admet-757	86	7	applied	apply	VERB
admet-757	86	8	from	from	ADP
admet-757	86	9	0	0	NUM
admet-757	86	10	to	to	ADP
admet-757	86	11	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	87	1	klara	klara	PROPN
admet-757	87	2	valko	valko	PROPN
admet-757	87	3	et	et	PROPN
admet-757	87	4	al	al	PROPN
admet-757	87	5	.	.	PROPN
admet-757	87	6	admet	admet	PROPN
admet-757	87	7	&	&	CCONJ
admet-757	87	8	dmpk	dmpk	PROPN
admet-757	87	9	8(1	8(1	NOUN
admet-757	87	10	)	)	PUNCT
admet-757	87	11	(	(	PUNCT
admet-757	87	12	2020	2020	NUM
admet-757	87	13	)	)	PUNCT
admet-757	87	14	78	78	NUM
admet-757	87	15	-	-	SYM
admet-757	87	16	97	97	NUM
admet-757	87	17	82	82	NUM
admet-757	87	18	35	35	NUM
admet-757	87	19	%	%	NOUN
admet-757	87	20	from	from	ADP
admet-757	87	21	0	0	NUM
admet-757	87	22	to	to	ADP
admet-757	87	23	3.00	3.00	NUM
admet-757	87	24	min	min	NOUN
admet-757	87	25	and	and	CCONJ
admet-757	87	26	kept	keep	VERB
admet-757	87	27	at	at	ADP
admet-757	87	28	35	35	NUM
admet-757	87	29	%	%	NOUN
admet-757	87	30	until	until	ADP
admet-757	87	31	4.00	4.00	NUM
admet-757	87	32	min	min	NOUN
admet-757	87	33	.	.	PROPN
admet-757	87	34	from	from	ADP
admet-757	87	35	4.00	4.00	NUM
admet-757	87	36	to	to	ADP
admet-757	87	37	4.25	4.25	NUM
admet-757	87	38	min	min	NOUN
admet-757	87	39	the	the	DET
admet-757	87	40	2	2	NUM
admet-757	87	41	-	-	PUNCT
admet-757	87	42	propanol	propanol	NOUN
admet-757	87	43	concentration	concentration	NOUN
admet-757	87	44	was	be	AUX
admet-757	87	45	dropped	drop	VERB
admet-757	87	46	back	back	ADV
admet-757	87	47	to	to	ADP
admet-757	87	48	0	0	NUM
admet-757	87	49	%	%	NOUN
admet-757	87	50	.	.	PUNCT
admet-757	88	1	although	although	SCONJ
admet-757	88	2	column	column	NOUN
admet-757	88	3	manufacturers	manufacturer	NOUN
admet-757	88	4	suggest	suggest	VERB
admet-757	88	5	using	use	VERB
admet-757	88	6	ph	ph	PROPN
admet-757	88	7	7	7	NUM
admet-757	88	8	for	for	ADP
admet-757	88	9	chiral	chiral	ADJ
admet-757	88	10	separations	separation	NOUN
admet-757	88	11	using	use	VERB
admet-757	88	12	the	the	DET
admet-757	88	13	hsa	hsa	PROPN
admet-757	88	14	column	column	NOUN
admet-757	88	15	,	,	PUNCT
admet-757	88	16	in	in	ADP
admet-757	88	17	this	this	DET
admet-757	88	18	case	case	NOUN
admet-757	88	19	,	,	PUNCT
admet-757	88	20	the	the	DET
admet-757	88	21	ph	ph	ADJ
admet-757	88	22	7.4	7.4	NUM
admet-757	88	23	mobile	mobile	ADJ
admet-757	88	24	phase	phase	NOUN
admet-757	88	25	is	be	AUX
admet-757	88	26	used	use	VERB
admet-757	88	27	to	to	PART
admet-757	88	28	mimic	mimic	VERB
admet-757	88	29	the	the	DET
admet-757	88	30	plasma	plasma	NOUN
admet-757	88	31	ph	ph	NOUN
admet-757	88	32	for	for	ADP
admet-757	88	33	the	the	DET
admet-757	88	34	plasma	plasma	NOUN
admet-757	88	35	protein	protein	NOUN
admet-757	88	36	binding	bind	VERB
admet-757	88	37	measurements	measurement	NOUN
admet-757	88	38	.	.	PUNCT
admet-757	89	1	table	table	NOUN
admet-757	89	2	1	1	NUM
admet-757	89	3	.	.	PUNCT
admet-757	90	1	the	the	DET
admet-757	90	2	constant	constant	ADJ
admet-757	90	3	chi	chi	NOUN
admet-757	90	4	(	(	PUNCT
admet-757	90	5	iam	iam	PROPN
admet-757	90	6	)	)	PUNCT
admet-757	90	7	and	and	CCONJ
admet-757	90	8	log	log	VERB
admet-757	90	9	k	k	PROPN
admet-757	90	10	(	(	PUNCT
admet-757	90	11	iam	iam	PROPN
admet-757	90	12	)	)	PUNCT
admet-757	90	13	values	value	NOUN
admet-757	90	14	for	for	ADP
admet-757	90	15	the	the	DET
admet-757	90	16	calibration	calibration	NOUN
admet-757	90	17	set	set	NOUN
admet-757	90	18	of	of	ADP
admet-757	90	19	compounds	compound	NOUN
admet-757	90	20	with	with	ADP
admet-757	90	21	typical	typical	ADJ
admet-757	90	22	retention	retention	NOUN
admet-757	90	23	times	time	NOUN
admet-757	90	24	.	.	PUNCT
admet-757	91	1	the	the	DET
admet-757	91	2	retention	retention	NOUN
admet-757	91	3	times	time	NOUN
admet-757	91	4	were	be	AUX
admet-757	91	5	standardized	standardize	VERB
admet-757	91	6	using	use	VERB
admet-757	91	7	the	the	DET
admet-757	91	8	calibration	calibration	NOUN
admet-757	91	9	set	set	NOUN
admet-757	91	10	of	of	ADP
admet-757	91	11	compounds	compound	NOUN
admet-757	91	12	described	describe	VERB
admet-757	91	13	previously	previously	ADV
admet-757	91	14	[	[	X
admet-757	91	15	23	23	NUM
admet-757	91	16	]	]	PUNCT
admet-757	91	17	.	.	PUNCT
admet-757	92	1	compounds	compound	NOUN
admet-757	92	2	studied	study	VERB
admet-757	92	3	in	in	ADP
admet-757	92	4	this	this	DET
admet-757	92	5	study	study	NOUN
admet-757	92	6	,	,	PUNCT
admet-757	92	7	72	72	NUM
admet-757	92	8	commercial	commercial	ADJ
admet-757	92	9	drugs	drug	NOUN
admet-757	92	10	from	from	ADP
admet-757	92	11	diverse	diverse	ADJ
admet-757	92	12	therapeutic	therapeutic	ADJ
admet-757	92	13	areas	area	NOUN
admet-757	92	14	have	have	AUX
admet-757	92	15	been	be	AUX
admet-757	92	16	analysed	analyse	VERB
admet-757	92	17	.	.	PUNCT
admet-757	93	1	50	50	NUM
admet-757	93	2	µl	µl	NOUN
admet-757	93	3	of	of	ADP
admet-757	93	4	10	10	NUM
admet-757	93	5	mm	mm	PROPN
admet-757	93	6	dmso	dmso	ADJ
admet-757	93	7	solutions	solution	NOUN
admet-757	93	8	of	of	ADP
admet-757	93	9	the	the	DET
admet-757	93	10	drugs	drug	NOUN
admet-757	93	11	were	be	AUX
admet-757	93	12	diluted	dilute	VERB
admet-757	93	13	down	down	ADV
admet-757	93	14	to	to	ADP
admet-757	93	15	150	150	NUM
admet-757	93	16	µl	µl	ADP
admet-757	93	17	and	and	CCONJ
admet-757	93	18	10	10	NUM
admet-757	93	19	µl	µl	NOUN
admet-757	93	20	of	of	ADP
admet-757	93	21	the	the	DET
admet-757	93	22	diluted	diluted	ADJ
admet-757	93	23	solution	solution	NOUN
admet-757	93	24	was	be	AUX
admet-757	93	25	injected	inject	VERB
admet-757	93	26	onto	onto	ADP
admet-757	93	27	the	the	DET
admet-757	93	28	hplc	hplc	NOUN
admet-757	93	29	columns	column	NOUN
admet-757	93	30	.	.	PUNCT
admet-757	94	1	the	the	DET
admet-757	94	2	clinical	clinical	ADJ
admet-757	94	3	volume	volume	NOUN
admet-757	94	4	of	of	ADP
admet-757	94	5	distribution	distribution	NOUN
admet-757	94	6	data	datum	NOUN
admet-757	94	7	for	for	ADP
admet-757	94	8	all	all	PRON
admet-757	94	9	of	of	ADP
admet-757	94	10	the	the	DET
admet-757	94	11	drugs	drug	NOUN
admet-757	94	12	is	be	AUX
admet-757	94	13	available	available	ADJ
admet-757	94	14	in	in	ADP
admet-757	94	15	the	the	DET
admet-757	94	16	literature	literature	NOUN
admet-757	94	17	[	[	X
admet-757	94	18	13	13	NUM
admet-757	94	19	]	]	PUNCT
admet-757	94	20	.	.	PUNCT
admet-757	95	1	table	table	NOUN
admet-757	95	2	2	2	NUM
admet-757	95	3	shows	show	VERB
admet-757	95	4	the	the	DET
admet-757	95	5	marketed	market	VERB
admet-757	95	6	drug	drug	NOUN
admet-757	95	7	molecules	molecule	NOUN
admet-757	95	8	and	and	CCONJ
admet-757	95	9	their	their	PRON
admet-757	95	10	clinical	clinical	ADJ
admet-757	95	11	volume	volume	NOUN
admet-757	95	12	of	of	ADP
admet-757	95	13	distribution	distribution	NOUN
admet-757	95	14	data	datum	NOUN
admet-757	95	15	obtained	obtain	VERB
admet-757	95	16	from	from	ADP
admet-757	95	17	reference	reference	NOUN
admet-757	95	18	[	[	X
admet-757	95	19	13	13	NUM
admet-757	95	20	]	]	PUNCT
admet-757	95	21	and	and	CCONJ
admet-757	95	22	the	the	DET
admet-757	95	23	previously	previously	ADV
admet-757	95	24	measured	measure	VERB
admet-757	95	25	chi	chi	NOUN
admet-757	95	26	(	(	PUNCT
admet-757	95	27	iam	iam	PROPN
admet-757	95	28	)	)	PUNCT
admet-757	95	29	data	datum	NOUN
admet-757	95	30	[	[	X
admet-757	95	31	14	14	NUM
admet-757	95	32	]	]	PUNCT
admet-757	95	33	using	use	VERB
admet-757	95	34	an	an	DET
admet-757	95	35	iam	iam	PROPN
admet-757	95	36	column	column	NOUN
admet-757	95	37	manufactured	manufacture	VERB
admet-757	95	38	by	by	ADP
admet-757	95	39	regis	regis	PROPN
admet-757	95	40	technologies	technology	NOUN
admet-757	95	41	between	between	ADP
admet-757	95	42	2004	2004	NUM
admet-757	95	43	and	and	CCONJ
admet-757	95	44	2012	2012	NUM
admet-757	95	45	.	.	PUNCT
admet-757	96	1	data	datum	NOUN
admet-757	96	2	analysis	analysis	NOUN
admet-757	96	3	the	the	DET
admet-757	96	4	statistical	statistical	ADJ
admet-757	96	5	analysis	analysis	NOUN
admet-757	96	6	was	be	AUX
admet-757	96	7	performed	perform	VERB
admet-757	96	8	using	use	VERB
admet-757	96	9	jmp	jmp	PROPN
admet-757	96	10	13	13	NUM
admet-757	96	11	(	(	PUNCT
admet-757	96	12	sas	sas	PROPN
admet-757	96	13	institute	institute	PROPN
admet-757	96	14	,	,	PUNCT
admet-757	96	15	usa	usa	PROPN
admet-757	96	16	)	)	PUNCT
admet-757	96	17	.	.	PUNCT
admet-757	97	1	results	result	NOUN
admet-757	97	2	and	and	CCONJ
admet-757	97	3	discussion	discussion	VERB
admet-757	97	4	the	the	DET
admet-757	97	5	selectivity	selectivity	NOUN
admet-757	97	6	and	and	CCONJ
admet-757	97	7	reproducibility	reproducibility	NOUN
admet-757	97	8	of	of	ADP
admet-757	97	9	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	97	10	columns	column	NOUN
admet-757	97	11	have	have	AUX
admet-757	97	12	been	be	AUX
admet-757	97	13	extensively	extensively	ADV
admet-757	97	14	studied	study	VERB
admet-757	97	15	.	.	PUNCT
admet-757	98	1	first	first	ADV
admet-757	98	2	,	,	PUNCT
admet-757	98	3	the	the	DET
admet-757	98	4	chi	chi	NOUN
admet-757	98	5	(	(	PUNCT
admet-757	98	6	iam	iam	PROPN
admet-757	98	7	)	)	PUNCT
admet-757	98	8	values	value	NOUN
admet-757	98	9	of	of	ADP
admet-757	98	10	the	the	DET
admet-757	98	11	system	system	NOUN
admet-757	98	12	suitability	suitability	NOUN
admet-757	98	13	test	test	NOUN
admet-757	98	14	compounds	compound	NOUN
admet-757	98	15	(	(	PUNCT
admet-757	98	16	see	see	VERB
admet-757	98	17	table	table	NOUN
admet-757	98	18	2	2	NUM
admet-757	98	19	)	)	PUNCT
admet-757	98	20	were	be	AUX
admet-757	98	21	scrutinized	scrutinize	VERB
admet-757	98	22	.	.	PUNCT
admet-757	99	1	the	the	DET
admet-757	99	2	chi	chi	PROPN
admet-757	99	3	(	(	PUNCT
admet-757	99	4	iam	iam	PROPN
admet-757	99	5	)	)	PUNCT
admet-757	99	6	values	value	NOUN
admet-757	99	7	of	of	ADP
admet-757	99	8	the	the	DET
admet-757	99	9	test	test	NOUN
admet-757	99	10	compounds	compound	NOUN
admet-757	99	11	were	be	AUX
admet-757	99	12	then	then	ADV
admet-757	99	13	compared	compare	VERB
admet-757	99	14	with	with	ADP
admet-757	99	15	the	the	DET
admet-757	99	16	chi	chi	NOUN
admet-757	99	17	(	(	PUNCT
admet-757	99	18	iam	iam	PROPN
admet-757	99	19	)	)	PUNCT
admet-757	99	20	values	value	NOUN
admet-757	99	21	obtained	obtain	VERB
admet-757	99	22	on	on	ADP
admet-757	99	23	the	the	DET
admet-757	99	24	new	new	ADJ
admet-757	99	25	batches	batch	NOUN
admet-757	99	26	of	of	ADP
admet-757	99	27	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	99	28	columns	column	NOUN
admet-757	99	29	.	.	PUNCT
admet-757	100	1	it	it	PRON
admet-757	100	2	was	be	AUX
admet-757	100	3	found	find	VERB
admet-757	100	4	,	,	PUNCT
admet-757	100	5	as	as	SCONJ
admet-757	100	6	shown	show	VERB
admet-757	100	7	in	in	ADP
admet-757	100	8	table	table	NOUN
admet-757	100	9	3	3	NUM
admet-757	100	10	,	,	PUNCT
admet-757	100	11	that	that	DET
admet-757	100	12	carbamazepine	carbamazepine	NOUN
admet-757	100	13	,	,	PUNCT
admet-757	100	14	warfarin	warfarin	NOUN
admet-757	100	15	,	,	PUNCT
admet-757	100	16	indomethacin	indomethacin	NOUN
admet-757	100	17	,	,	PUNCT
admet-757	100	18	nicardipine	nicardipine	NOUN
admet-757	100	19	,	,	PUNCT
admet-757	100	20	ketoprofen	ketoprofen	VERB
admet-757	100	21	,	,	PUNCT
admet-757	100	22	haloperidol	haloperidol	NOUN
admet-757	100	23	and	and	CCONJ
admet-757	100	24	budesonide	budesonide	PROPN
admet-757	100	25	had	have	VERB
admet-757	100	26	very	very	ADV
admet-757	100	27	similar	similar	ADJ
admet-757	100	28	chi	chi	NOUN
admet-757	100	29	(	(	PUNCT
admet-757	100	30	iam	iam	PROPN
admet-757	100	31	)	)	PUNCT
admet-757	100	32	values	value	NOUN
admet-757	100	33	.	.	PUNCT
admet-757	101	1	however	however	ADV
admet-757	101	2	,	,	PUNCT
admet-757	101	3	imipramine	imipramine	NOUN
admet-757	101	4	and	and	CCONJ
admet-757	101	5	chlorpromazine	chlorpromazine	NOUN
admet-757	101	6	showed	show	VERB
admet-757	101	7	greater	great	ADJ
admet-757	101	8	than	than	ADP
admet-757	101	9	the	the	DET
admet-757	101	10	5	5	NUM
admet-757	101	11	chi	chi	NOUN
admet-757	101	12	(	(	PUNCT
admet-757	101	13	iam	iam	PROPN
admet-757	101	14	)	)	PUNCT
admet-757	101	15	unit	unit	NOUN
admet-757	101	16	deviations	deviation	NOUN
admet-757	101	17	which	which	PRON
admet-757	101	18	would	would	AUX
admet-757	101	19	be	be	AUX
admet-757	101	20	within	within	ADP
admet-757	101	21	the	the	DET
admet-757	101	22	experimental	experimental	ADJ
admet-757	101	23	error	error	NOUN
admet-757	101	24	and	and	CCONJ
admet-757	101	25	therefore	therefore	ADV
admet-757	101	26	they	they	PRON
admet-757	101	27	did	do	AUX
admet-757	101	28	not	not	PART
admet-757	101	29	pass	pass	VERB
admet-757	101	30	the	the	DET
admet-757	101	31	system	system	NOUN
admet-757	101	32	suitability	suitability	NOUN
admet-757	101	33	criteria	criterion	NOUN
admet-757	101	34	.	.	PUNCT
admet-757	102	1	these	these	DET
admet-757	102	2	compounds	compound	NOUN
admet-757	102	3	are	be	AUX
admet-757	102	4	strong	strong	ADJ
admet-757	102	5	bases	basis	NOUN
admet-757	102	6	and	and	CCONJ
admet-757	102	7	positively	positively	ADV
admet-757	102	8	charged	charge	VERB
admet-757	102	9	at	at	ADP
admet-757	102	10	ph	ph	PROPN
admet-757	102	11	7.4	7.4	NUM
admet-757	102	12	.	.	PUNCT
admet-757	103	1	most	most	ADJ
admet-757	103	2	probably	probably	ADV
admet-757	103	3	the	the	DET
admet-757	103	4	new	new	ADJ
admet-757	103	5	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	103	6	columns	column	NOUN
admet-757	103	7	have	have	VERB
admet-757	103	8	less	less	ADV
admet-757	103	9	negative	negative	ADJ
admet-757	103	10	charge	charge	NOUN
admet-757	103	11	on	on	ADP
admet-757	103	12	the	the	DET
admet-757	103	13	surface	surface	NOUN
admet-757	103	14	and	and	CCONJ
admet-757	103	15	therefore	therefore	ADV
admet-757	103	16	reduce	reduce	VERB
admet-757	103	17	the	the	DET
admet-757	103	18	retention	retention	NOUN
admet-757	103	19	times	time	NOUN
admet-757	103	20	of	of	ADP
admet-757	103	21	positively	positively	ADV
admet-757	103	22	charged	charge	VERB
admet-757	103	23	compounds	compound	NOUN
admet-757	103	24	.	.	PUNCT
admet-757	104	1	it	it	PRON
admet-757	104	2	is	be	AUX
admet-757	104	3	also	also	ADV
admet-757	104	4	possible	possible	ADJ
admet-757	104	5	that	that	SCONJ
admet-757	104	6	more	more	ADJ
admet-757	104	7	of	of	ADP
admet-757	104	8	the	the	DET
admet-757	104	9	free	free	ADJ
admet-757	104	10	silanol	silanol	NOUN
admet-757	104	11	groups	group	NOUN
admet-757	104	12	were	be	AUX
admet-757	104	13	end	end	NOUN
admet-757	104	14	-	-	PUNCT
admet-757	104	15	capped	cap	VERB
admet-757	104	16	which	which	PRON
admet-757	104	17	would	would	AUX
admet-757	104	18	contribute	contribute	VERB
admet-757	104	19	to	to	ADP
admet-757	104	20	a	a	DET
admet-757	104	21	shorter	short	ADJ
admet-757	104	22	retention	retention	NOUN
admet-757	104	23	of	of	ADP
admet-757	104	24	basic	basic	ADJ
admet-757	104	25	compounds	compound	NOUN
admet-757	104	26	.	.	PUNCT
admet-757	105	1	therefore	therefore	ADV
admet-757	105	2	,	,	PUNCT
admet-757	105	3	the	the	DET
admet-757	105	4	system	system	NOUN
admet-757	105	5	suitability	suitability	NOUN
admet-757	105	6	criteria	criterion	NOUN
admet-757	105	7	were	be	AUX
admet-757	105	8	changed	change	VERB
admet-757	105	9	for	for	ADP
admet-757	105	10	basic	basic	ADJ
admet-757	105	11	compounds	compound	NOUN
admet-757	105	12	.	.	PUNCT
admet-757	106	1	the	the	DET
admet-757	106	2	“	"	PUNCT
admet-757	106	3	new	new	ADJ
admet-757	106	4	”	"	PUNCT
admet-757	106	5	chi	chi	NOUN
admet-757	106	6	(	(	PUNCT
admet-757	106	7	iam	iam	PROPN
admet-757	106	8	)	)	PUNCT
admet-757	106	9	values	value	NOUN
admet-757	106	10	are	be	AUX
admet-757	106	11	listed	list	VERB
admet-757	106	12	in	in	ADP
admet-757	106	13	table	table	NOUN
admet-757	106	14	3	3	NUM
admet-757	106	15	.	.	PUNCT
admet-757	107	1	the	the	DET
admet-757	107	2	in	in	ADP
admet-757	107	3	vivo	vivo	ADJ
admet-757	107	4	distribution	distribution	NOUN
admet-757	107	5	models	model	NOUN
admet-757	107	6	were	be	AUX
admet-757	107	7	re	re	VERB
admet-757	107	8	-	-	VERB
admet-757	107	9	examined	examine	VERB
admet-757	107	10	using	use	VERB
admet-757	107	11	the	the	DET
admet-757	107	12	data	datum	NOUN
admet-757	107	13	from	from	ADP
admet-757	107	14	the	the	DET
admet-757	107	15	new	new	ADJ
admet-757	107	16	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	107	17	columns	column	NOUN
admet-757	107	18	.	.	PUNCT
admet-757	108	1	because	because	SCONJ
admet-757	108	2	of	of	ADP
admet-757	108	3	the	the	DET
admet-757	108	4	selectivity	selectivity	NOUN
admet-757	108	5	differences	difference	NOUN
admet-757	108	6	,	,	PUNCT
admet-757	108	7	it	it	PRON
admet-757	108	8	was	be	AUX
admet-757	108	9	essential	essential	ADJ
admet-757	108	10	to	to	PART
admet-757	108	11	investigate	investigate	VERB
admet-757	108	12	the	the	DET
admet-757	108	13	chi	chi	NOUN
admet-757	108	14	(	(	PUNCT
admet-757	108	15	iam	iam	PROPN
admet-757	108	16	)	)	PUNCT
admet-757	108	17	values	value	NOUN
admet-757	108	18	for	for	ADP
admet-757	108	19	a	a	DET
admet-757	108	20	larger	large	ADJ
admet-757	108	21	set	set	NOUN
admet-757	108	22	of	of	ADP
admet-757	108	23	compounds	compound	NOUN
admet-757	108	24	and	and	CCONJ
admet-757	108	25	check	check	VERB
admet-757	108	26	how	how	SCONJ
admet-757	108	27	the	the	DET
admet-757	108	28	previously	previously	ADV
admet-757	108	29	described	describe	VERB
admet-757	108	30	in	in	ADP
admet-757	108	31	vivo	vivo	ADJ
admet-757	108	32	distribution	distribution	NOUN
admet-757	108	33	models	model	NOUN
admet-757	108	34	performed	perform	VERB
admet-757	108	35	using	use	VERB
admet-757	108	36	the	the	DET
admet-757	108	37	data	datum	NOUN
admet-757	108	38	from	from	ADP
admet-757	108	39	the	the	DET
admet-757	108	40	new	new	ADJ
admet-757	108	41	columns	column	NOUN
admet-757	108	42	manufactured	manufacture	VERB
admet-757	108	43	with	with	ADP
admet-757	108	44	the	the	DET
admet-757	108	45	new	new	ADJ
admet-757	108	46	silica	silica	NOUN
admet-757	108	47	material	material	NOUN
admet-757	108	48	.	.	PUNCT
admet-757	109	1	the	the	DET
admet-757	109	2	72	72	NUM
admet-757	109	3	drug	drug	NOUN
admet-757	109	4	molecules	molecule	NOUN
admet-757	109	5	from	from	ADP
admet-757	109	6	the	the	DET
admet-757	109	7	original	original	ADJ
admet-757	109	8	set	set	NOUN
admet-757	109	9	of	of	ADP
admet-757	109	10	marketed	market	VERB
admet-757	109	11	drugs	drug	NOUN
admet-757	109	12	for	for	ADP
admet-757	109	13	which	which	PRON
admet-757	109	14	the	the	DET
admet-757	109	15	models	model	NOUN
admet-757	109	16	were	be	AUX
admet-757	109	17	developed	develop	VERB
admet-757	109	18	[	[	PUNCT
admet-757	109	19	13	13	NUM
admet-757	109	20	]	]	PUNCT
admet-757	109	21	were	be	AUX
admet-757	109	22	analysed	analyse	VERB
admet-757	109	23	on	on	ADP
admet-757	109	24	the	the	DET
admet-757	109	25	new	new	ADJ
admet-757	109	26	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	109	27	columns	column	NOUN
admet-757	109	28	and	and	CCONJ
admet-757	109	29	the	the	DET
admet-757	109	30	hsa	hsa	PROPN
admet-757	109	31	column	column	NOUN
admet-757	109	32	.	.	PUNCT
admet-757	110	1	table	table	NOUN
admet-757	110	2	4	4	NUM
admet-757	110	3	shows	show	VERB
admet-757	110	4	the	the	DET
admet-757	110	5	chi	chi	NOUN
admet-757	110	6	(	(	PUNCT
admet-757	110	7	iam	iam	PROPN
admet-757	110	8	)	)	PUNCT
admet-757	110	9	values	value	NOUN
admet-757	110	10	and	and	CCONJ
admet-757	110	11	the	the	DET
admet-757	110	12	log	log	NOUN
admet-757	110	13	k	k	PROPN
admet-757	110	14	hsa	hsa	PROPN
admet-757	110	15	binding	bind	VERB
admet-757	110	16	data	datum	NOUN
admet-757	110	17	obtained	obtain	VERB
admet-757	110	18	from	from	ADP
admet-757	110	19	reference	reference	NOUN
admet-757	110	20	[	[	X
admet-757	110	21	13	13	NUM
admet-757	110	22	]	]	PUNCT
admet-757	110	23	and	and	CCONJ
admet-757	110	24	remeasured	remeasure	VERB
admet-757	110	25	in	in	ADP
admet-757	110	26	this	this	DET
admet-757	110	27	study	study	NOUN
admet-757	110	28	.	.	PUNCT
admet-757	111	1	compound	compound	NOUN
admet-757	111	2	chi	chi	PROPN
admet-757	111	3	(	(	PUNCT
admet-757	111	4	iam	iam	PROPN
admet-757	111	5	)	)	PUNCT
admet-757	111	6	log	log	NOUN
admet-757	111	7	k	k	PROPN
admet-757	111	8	(	(	PUNCT
admet-757	111	9	iam	iam	PROPN
admet-757	111	10	)	)	PUNCT
admet-757	111	11	tr	tr	VERB
admet-757	111	12	7.4	7.4	NUM
admet-757	111	13	(	(	PUNCT
admet-757	111	14	min	min	NOUN
admet-757	111	15	)	)	PUNCT
admet-757	111	16	octanophenone	octanophenone	NOUN
admet-757	111	17	49.4	49.4	NUM
admet-757	111	18	4.97	4.97	NUM
admet-757	111	19	4.37	4.37	NUM
admet-757	111	20	heptanophenone	heptanophenone	NOUN
admet-757	111	21	45.7	45.7	NUM
admet-757	111	22	4.30	4.30	NUM
admet-757	111	23	4.17	4.17	NUM
admet-757	111	24	hexanophenone	hexanophenone	NOUN
admet-757	111	25	41.8	41.8	NUM
admet-757	111	26	3.71	3.71	NUM
admet-757	111	27	3.93	3.93	NUM
admet-757	111	28	valerophenone	valerophenone	NOUN
admet-757	111	29	37.3	37.3	NUM
admet-757	111	30	3.16	3.16	NUM
admet-757	111	31	3.66	3.66	NUM
admet-757	111	32	butyrophenone	butyrophenone	NOUN
admet-757	111	33	32.0	32.0	NUM
admet-757	111	34	2.62	2.62	NUM
admet-757	111	35	3.32	3.32	NUM
admet-757	111	36	propiophenone	propiophenone	NOUN
admet-757	111	37	25.9	25.9	NUM
admet-757	111	38	2.15	2.15	NUM
admet-757	111	39	2.90	2.90	NUM
admet-757	111	40	acetophenone	acetophenone	NOUN
admet-757	111	41	17.2	17.2	NUM
admet-757	111	42	1.67	1.67	NUM
admet-757	111	43	2.34	2.34	NUM
admet-757	111	44	acetanilide	acetanilide	ADV
admet-757	111	45	11.5	11.5	NUM
admet-757	111	46	1.45	1.45	NUM
admet-757	111	47	2.04	2.04	NUM
admet-757	111	48	paracetamol	paracetamol	NOUN
admet-757	111	49	2.90	2.90	NUM
admet-757	111	50	1.20	1.20	NUM
admet-757	111	51	1.58	1.58	NUM
admet-757	111	52	admet	admet	NOUN
admet-757	111	53	&	&	CCONJ
admet-757	111	54	dmpk	dmpk	PROPN
admet-757	111	55	8(1	8(1	NOUN
admet-757	111	56	)	)	PUNCT
admet-757	111	57	(	(	PUNCT
admet-757	111	58	2020	2020	NUM
admet-757	111	59	)	)	PUNCT
admet-757	111	60	78	78	NUM
admet-757	111	61	-	-	SYM
admet-757	111	62	97	97	NUM
admet-757	111	63	revisiting	revisit	VERB
admet-757	111	64	the	the	DET
admet-757	111	65	iam	iam	PROPN
admet-757	111	66	chromatography	chromatography	NOUN
admet-757	111	67	doi	doi	PROPN
admet-757	111	68	:	:	PUNCT
admet-757	111	69	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	111	70	83	83	NUM
admet-757	111	71	table	table	NOUN
admet-757	111	72	2	2	NUM
admet-757	111	73	.	.	PUNCT
admet-757	112	1	the	the	DET
admet-757	112	2	name	name	NOUN
admet-757	112	3	of	of	ADP
admet-757	112	4	the	the	DET
admet-757	112	5	marketed	market	VERB
admet-757	112	6	drugs	drug	NOUN
admet-757	112	7	,	,	PUNCT
admet-757	112	8	their	their	PRON
admet-757	112	9	cas	cas	NOUN
admet-757	112	10	number	number	NOUN
admet-757	112	11	,	,	PUNCT
admet-757	112	12	their	their	PRON
admet-757	112	13	previously	previously	ADV
admet-757	112	14	published	publish	VERB
admet-757	112	15	chi	chi	NOUN
admet-757	112	16	(	(	PUNCT
admet-757	112	17	iam	iam	PROPN
admet-757	112	18	)	)	PUNCT
admet-757	112	19	data	datum	NOUN
admet-757	112	20	and	and	CCONJ
admet-757	112	21	the	the	DET
admet-757	112	22	logarithm	logarithm	NOUN
admet-757	112	23	of	of	ADP
admet-757	112	24	their	their	PRON
admet-757	112	25	clinical	clinical	ADJ
admet-757	112	26	volume	volume	NOUN
admet-757	112	27	of	of	ADP
admet-757	112	28	distribution	distribution	NOUN
admet-757	112	29	.	.	PUNCT
admet-757	113	1	compound	compound	NOUN
admet-757	113	2	cas	cas	PROPN
admet-757	113	3	no	no	DET
admet-757	113	4	acid	acid	NOUN
admet-757	113	5	/	/	SYM
admet-757	113	6	base	base	NOUN
admet-757	113	7	character	character	NOUN
admet-757	113	8	chi	chi	NOUN
admet-757	113	9	(	(	PUNCT
admet-757	113	10	iam	iam	PROPN
admet-757	113	11	)	)	PUNCT
admet-757	114	1	[	[	X
admet-757	114	2	14	14	NUM
admet-757	114	3	]	]	X
admet-757	114	4	log	log	VERB
admet-757	114	5	vdss	vdss	ADV
admet-757	115	1	[	[	X
admet-757	115	2	13	13	NUM
admet-757	115	3	]	]	SYM
admet-757	115	4	acecainide	acecainide	NOUN
admet-757	115	5	32795	32795	NUM
admet-757	115	6	-	-	SYM
admet-757	115	7	44	44	NUM
admet-757	115	8	-	-	SYM
admet-757	115	9	1	1	NUM
admet-757	115	10	basic	basic	ADJ
admet-757	115	11	23.3	23.3	NUM
admet-757	115	12	0.10	0.10	NUM
admet-757	115	13	acetanilide	acetanilide	ADJ
admet-757	115	14	103	103	NUM
admet-757	115	15	-	-	SYM
admet-757	115	16	84	84	NUM
admet-757	115	17	-	-	SYM
admet-757	115	18	4	4	NUM
admet-757	115	19	neutral	neutral	ADJ
admet-757	115	20	10.7	10.7	NUM
admet-757	115	21	-0.13	-0.13	NUM
admet-757	115	22	acetazolamide	acetazolamide	ADV
admet-757	115	23	59	59	NUM
admet-757	115	24	-	-	SYM
admet-757	115	25	66	66	NUM
admet-757	115	26	-	-	SYM
admet-757	115	27	5	5	NUM
admet-757	115	28	neutral	neutral	ADJ
admet-757	115	29	1.7	1.7	NUM
admet-757	115	30	-0.46	-0.46	NUM
admet-757	115	31	alclofenac	alclofenac	ADJ
admet-757	115	32	22131	22131	NUM
admet-757	115	33	-	-	SYM
admet-757	115	34	79	79	NUM
admet-757	115	35	-	-	SYM
admet-757	115	36	9	9	NUM
admet-757	115	37	acidic	acidic	ADJ
admet-757	115	38	17.8	17.8	NUM
admet-757	115	39	-1.10	-1.10	NOUN
admet-757	115	40	amoxapine	amoxapine	NOUN
admet-757	115	41	14028	14028	NUM
admet-757	115	42	-	-	SYM
admet-757	115	43	44	44	NUM
admet-757	115	44	-	-	SYM
admet-757	115	45	5	5	NUM
admet-757	115	46	basic	basic	ADJ
admet-757	115	47	56.5	56.5	NUM
admet-757	115	48	1.67	1.67	NUM
admet-757	115	49	bamethan	bamethan	NOUN
admet-757	115	50	3703	3703	NUM
admet-757	115	51	-	-	SYM
admet-757	115	52	79	79	NUM
admet-757	115	53	-	-	SYM
admet-757	115	54	5	5	NUM
admet-757	115	55	basic	basic	ADJ
admet-757	115	56	18.6	18.6	NUM
admet-757	115	57	0.01	0.01	NUM
admet-757	115	58	betamethasone	betamethasone	PROPN
admet-757	115	59	378	378	NUM
admet-757	115	60	-	-	SYM
admet-757	115	61	44	44	NUM
admet-757	115	62	-	-	SYM
admet-757	115	63	9	9	NUM
admet-757	115	64	neutral	neutral	ADJ
admet-757	115	65	31.7	31.7	NUM
admet-757	115	66	0.18	0.18	NUM
admet-757	115	67	carbamazepine	carbamazepine	NOUN
admet-757	115	68	298	298	NUM
admet-757	115	69	-	-	SYM
admet-757	115	70	46	46	NUM
admet-757	115	71	-	-	SYM
admet-757	115	72	4	4	NUM
admet-757	115	73	neutral	neutral	ADJ
admet-757	115	74	26.5	26.5	NUM
admet-757	115	75	-0.09	-0.09	NUM
admet-757	115	76	chlorpromazine	chlorpromazine	NOUN
admet-757	115	77	50	50	NUM
admet-757	115	78	-	-	SYM
admet-757	115	79	53	53	NUM
admet-757	115	80	-	-	SYM
admet-757	115	81	3	3	NUM
admet-757	115	82	basic	basic	ADJ
admet-757	115	83	61.9	61.9	NUM
admet-757	115	84	2.15	2.15	NUM
admet-757	115	85	cinoxacin	cinoxacin	NOUN
admet-757	115	86	28657	28657	NUM
admet-757	115	87	-	-	SYM
admet-757	115	88	80	80	NUM
admet-757	115	89	-	-	PUNCT
admet-757	115	90	9	9	NUM
admet-757	115	91	acidic	acidic	ADJ
admet-757	115	92	1.6	1.6	NUM
admet-757	115	93	-0.42	-0.42	NUM
admet-757	115	94	colchicine	colchicine	PROPN
admet-757	115	95	64	64	NUM
admet-757	115	96	-	-	SYM
admet-757	115	97	86	86	NUM
admet-757	115	98	-	-	SYM
admet-757	115	99	8	8	NUM
admet-757	115	100	neutral	neutral	ADJ
admet-757	115	101	23.7	23.7	NUM
admet-757	115	102	0.03	0.03	NUM
admet-757	115	103	cytarabine	cytarabine	NOUN
admet-757	115	104	147	147	NUM
admet-757	115	105	-	-	SYM
admet-757	115	106	94	94	NUM
admet-757	115	107	-	-	SYM
admet-757	115	108	4	4	NUM
admet-757	115	109	weak	weak	ADJ
admet-757	115	110	base	base	NOUN
admet-757	115	111	-15.0	-15.0	PUNCT
admet-757	115	112	-0.31	-0.31	NUM
admet-757	115	113	diazoxide	diazoxide	NOUN
admet-757	115	114	364	364	NUM
admet-757	115	115	-	-	SYM
admet-757	115	116	98	98	NUM
admet-757	115	117	-	-	SYM
admet-757	115	118	7	7	NUM
admet-757	115	119	weak	weak	ADJ
admet-757	115	120	acid	acid	NOUN
admet-757	115	121	24.7	24.7	NUM
admet-757	115	122	-0.16	-0.16	DET
admet-757	115	123	diclofenac	diclofenac	NOUN
admet-757	115	124	15307	15307	NUM
admet-757	115	125	-	-	SYM
admet-757	115	126	86	86	NUM
admet-757	115	127	-	-	SYM
admet-757	115	128	5	5	NUM
admet-757	115	129	acidic	acidic	ADJ
admet-757	115	130	33.5	33.5	NUM
admet-757	115	131	-0.67	-0.67	NOUN
admet-757	115	132	diprophylline	diprophylline	ADJ
admet-757	115	133	479	479	NUM
admet-757	115	134	-	-	SYM
admet-757	115	135	18	18	NUM
admet-757	115	136	-	-	SYM
admet-757	115	137	5	5	NUM
admet-757	115	138	neutral	neutral	ADJ
admet-757	115	139	-4.0	-4.0	X
admet-757	115	140	-0.24	-0.24	ADJ
admet-757	115	141	ethinyl	ethinyl	NOUN
admet-757	115	142	estradiol	estradiol	PROPN
admet-757	115	143	57	57	NUM
admet-757	115	144	-	-	SYM
admet-757	115	145	63	63	NUM
admet-757	115	146	-	-	SYM
admet-757	115	147	6	6	NUM
admet-757	115	148	neutral	neutral	ADJ
admet-757	115	149	46.8	46.8	NUM
admet-757	115	150	0.39	0.39	NUM
admet-757	115	151	famotidine	famotidine	NOUN
admet-757	115	152	76824	76824	NUM
admet-757	115	153	-	-	SYM
admet-757	115	154	35	35	NUM
admet-757	115	155	-	-	SYM
admet-757	115	156	6	6	NUM
admet-757	115	157	weak	weak	ADJ
admet-757	115	158	base	base	NOUN
admet-757	115	159	15.7	15.7	NUM
admet-757	115	160	-0.06	-0.06	NUM
admet-757	115	161	felbamate	felbamate	NOUN
admet-757	115	162	25451	25451	NUM
admet-757	115	163	-	-	SYM
admet-757	115	164	15	15	NUM
admet-757	115	165	-	-	SYM
admet-757	115	166	4	4	NUM
admet-757	115	167	neutral	neutral	ADJ
admet-757	115	168	19.1	19.1	NUM
admet-757	115	169	-0.64	-0.64	NUM
admet-757	115	170	felodipine	felodipine	ADJ
admet-757	115	171	72509	72509	NUM
admet-757	115	172	-	-	SYM
admet-757	115	173	76	76	NUM
admet-757	115	174	-	-	SYM
admet-757	115	175	3	3	NUM
admet-757	115	176	neutral	neutral	ADJ
admet-757	115	177	46.1	46.1	NUM
admet-757	115	178	0.35	0.35	NUM
admet-757	115	179	fenoprofen	fenoprofen	NOUN
admet-757	115	180	31879	31879	NUM
admet-757	115	181	-	-	SYM
admet-757	115	182	05	05	NUM
admet-757	115	183	-	-	PUNCT
admet-757	115	184	7	7	NUM
admet-757	115	185	acidic	acidic	ADJ
admet-757	115	186	17.2	17.2	NUM
admet-757	115	187	-1.27	-1.27	NOUN
admet-757	115	188	finasteride	finasteride	ADJ
admet-757	115	189	98319	98319	NUM
admet-757	115	190	-	-	SYM
admet-757	115	191	26	26	NUM
admet-757	115	192	-	-	SYM
admet-757	115	193	7	7	NUM
admet-757	115	194	neutral	neutral	ADJ
admet-757	115	195	38.9	38.9	NUM
admet-757	115	196	0.30	0.30	NUM
admet-757	115	197	floxacillin	floxacillin	PROPN
admet-757	115	198	5250	5250	NUM
admet-757	115	199	-	-	SYM
admet-757	115	200	39	39	NUM
admet-757	115	201	-	-	SYM
admet-757	115	202	5	5	NUM
admet-757	115	203	acidic	acidic	ADJ
admet-757	115	204	23.4	23.4	NUM
admet-757	115	205	-0.56	-0.56	NUM
admet-757	115	206	flumazenil	flumazenil	NOUN
admet-757	115	207	78755	78755	NUM
admet-757	115	208	-	-	SYM
admet-757	115	209	81	81	NUM
admet-757	115	210	-	-	PUNCT
admet-757	115	211	4	4	NUM
admet-757	115	212	neutral	neutral	ADJ
admet-757	115	213	18.4	18.4	NUM
admet-757	115	214	-0.04	-0.04	NUM
admet-757	115	215	flurbiprofen	flurbiprofen	NOUN
admet-757	115	216	5104	5104	NUM
admet-757	115	217	-	-	SYM
admet-757	115	218	49	49	NUM
admet-757	115	219	-	-	SYM
admet-757	115	220	4	4	NUM
admet-757	115	221	acidic	acidic	ADJ
admet-757	115	222	26.8	26.8	NUM
admet-757	115	223	-1.56	-1.56	NUM
admet-757	115	224	furosemide	furosemide	ADJ
admet-757	115	225	54	54	NUM
admet-757	115	226	-	-	SYM
admet-757	115	227	31	31	NUM
admet-757	115	228	-	-	SYM
admet-757	115	229	9	9	NUM
admet-757	115	230	acidic	acidic	ADJ
admet-757	115	231	21.4	21.4	NUM
admet-757	115	232	-0.71	-0.71	NOUN
admet-757	115	233	gemfibrozil	gemfibrozil	NOUN
admet-757	115	234	25812	25812	NUM
admet-757	115	235	-	-	SYM
admet-757	115	236	30	30	NUM
admet-757	115	237	-	-	PUNCT
admet-757	115	238	0	0	NUM
admet-757	115	239	acidic	acidic	ADJ
admet-757	115	240	32.9	32.9	NUM
admet-757	115	241	-1.34	-1.34	NOUN
admet-757	115	242	glipizide	glipizide	NOUN
admet-757	115	243	29094	29094	NUM
admet-757	115	244	-	-	SYM
admet-757	115	245	61	61	NUM
admet-757	115	246	-	-	SYM
admet-757	115	247	9	9	NUM
admet-757	115	248	acidic	acidic	ADJ
admet-757	115	249	21.1	21.1	NUM
admet-757	115	250	-0.73	-0.73	CCONJ
admet-757	115	251	griseofulvin	griseofulvin	NOUN
admet-757	115	252	126	126	NUM
admet-757	115	253	-	-	SYM
admet-757	115	254	07	07	NUM
admet-757	115	255	-	-	PUNCT
admet-757	115	256	8	8	NUM
admet-757	115	257	neutral	neutral	ADJ
admet-757	115	258	33.1	33.1	NUM
admet-757	115	259	0.12	0.12	NUM
admet-757	115	260	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-757	115	261	58	58	NUM
admet-757	115	262	-	-	SYM
admet-757	115	263	93	93	NUM
admet-757	115	264	-	-	SYM
admet-757	115	265	5	5	NUM
admet-757	115	266	weak	weak	ADJ
admet-757	115	267	acid	acid	NOUN
admet-757	115	268	15.9	15.9	NUM
admet-757	115	269	-0.13	-0.13	NUM
admet-757	115	270	hydrocortisone	hydrocortisone	NOUN
admet-757	115	271	50	50	NUM
admet-757	115	272	-	-	SYM
admet-757	115	273	23	23	NUM
admet-757	115	274	-	-	SYM
admet-757	115	275	7	7	NUM
admet-757	115	276	neutral	neutral	ADJ
admet-757	115	277	27.9	27.9	NUM
admet-757	115	278	0.12	0.12	NUM
admet-757	115	279	imipramine	imipramine	ADJ
admet-757	115	280	50	50	NUM
admet-757	115	281	-	-	PUNCT
admet-757	115	282	49	49	NUM
admet-757	115	283	-	-	SYM
admet-757	115	284	7	7	NUM
admet-757	115	285	basic	basic	ADJ
admet-757	115	286	51.6	51.6	NUM
admet-757	115	287	1.16	1.16	NUM
admet-757	115	288	indomethacin	indomethacin	VERB
admet-757	115	289	53	53	NUM
admet-757	115	290	-	-	SYM
admet-757	115	291	86	86	NUM
admet-757	115	292	-	-	SYM
admet-757	115	293	1	1	NUM
admet-757	115	294	acidic	acidic	ADJ
admet-757	115	295	25.3	25.3	NUM
admet-757	115	296	-0.96	-0.96	NUM
admet-757	115	297	isradipine	isradipine	PROPN
admet-757	115	298	75695	75695	NUM
admet-757	115	299	-	-	SYM
admet-757	115	300	93	93	NUM
admet-757	115	301	-	-	SYM
admet-757	115	302	1	1	NUM
admet-757	115	303	neutral	neutral	ADJ
admet-757	115	304	40.0	40.0	NUM
admet-757	115	305	0.13	0.13	NUM
admet-757	115	306	ketoconazole	ketoconazole	NOUN
admet-757	115	307	65277	65277	NUM
admet-757	115	308	-	-	PUNCT
admet-757	115	309	42	42	NUM
admet-757	115	310	-	-	SYM
admet-757	115	311	1	1	NUM
admet-757	115	312	weak	weak	ADJ
admet-757	115	313	base	base	NOUN
admet-757	115	314	42.9	42.9	NUM
admet-757	115	315	0.32	0.32	NUM
admet-757	115	316	ketoprofen	ketoprofen	NOUN
admet-757	115	317	22071	22071	NUM
admet-757	115	318	-	-	SYM
admet-757	115	319	15	15	NUM
admet-757	115	320	-	-	SYM
admet-757	115	321	4	4	NUM
admet-757	115	322	acidic	acidic	ADJ
admet-757	115	323	21.9	21.9	NUM
admet-757	115	324	-1.01	-1.01	ADJ
admet-757	115	325	labetalol	labetalol	NOUN
admet-757	115	326	36894	36894	NUM
admet-757	115	327	-	-	SYM
admet-757	115	328	69	69	NUM
admet-757	115	329	-	-	SYM
admet-757	115	330	6	6	NUM
admet-757	115	331	amphoteric	amphoteric	ADJ
admet-757	115	332	43.9	43.9	NUM
admet-757	115	333	0.71	0.71	NUM
admet-757	115	334	lignocaine	lignocaine	NOUN
admet-757	115	335	137	137	NUM
admet-757	115	336	-	-	SYM
admet-757	115	337	58	58	NUM
admet-757	115	338	-	-	SYM
admet-757	115	339	6	6	NUM
admet-757	115	340	basic	basic	ADJ
admet-757	115	341	32.6	32.6	NUM
admet-757	115	342	0.40	0.40	NUM
admet-757	115	343	methylprednisolone	methylprednisolone	NOUN
admet-757	115	344	83	83	NUM
admet-757	115	345	-	-	PUNCT
admet-757	115	346	43	43	NUM
admet-757	115	347	-	-	SYM
admet-757	115	348	2	2	NUM
admet-757	115	349	neutral	neutral	ADJ
admet-757	115	350	32.1	32.1	NUM
admet-757	115	351	0.16	0.16	NUM
admet-757	115	352	metronidazole	metronidazole	NOUN
admet-757	115	353	443	443	NUM
admet-757	115	354	-	-	SYM
admet-757	115	355	48	48	NUM
admet-757	115	356	-	-	SYM
admet-757	115	357	1	1	NUM
admet-757	115	358	weak	weak	ADJ
admet-757	115	359	base	base	NOUN
admet-757	115	360	-3.3	-3.3	PROPN
admet-757	115	361	-0.25	-0.25	NUM
admet-757	115	362	minoxidil	minoxidil	NOUN
admet-757	115	363	38304	38304	NUM
admet-757	115	364	-	-	PUNCT
admet-757	115	365	91	91	NUM
admet-757	115	366	-	-	PUNCT
admet-757	115	367	5	5	NUM
admet-757	115	368	weak	weak	ADJ
admet-757	115	369	base	base	NOUN
admet-757	115	370	19.0	19.0	NUM
admet-757	115	371	-0.04	-0.04	NUM
admet-757	115	372	nabumetone	nabumetone	NOUN
admet-757	115	373	42924	42924	NUM
admet-757	115	374	-	-	SYM
admet-757	115	375	53	53	NUM
admet-757	115	376	-	-	PUNCT
admet-757	115	377	8	8	NUM
admet-757	115	378	neutral	neutral	ADJ
admet-757	115	379	38.4	38.4	NUM
admet-757	115	380	0.03	0.03	NUM
admet-757	115	381	nadolol	nadolol	X
admet-757	115	382	42200	42200	NUM
admet-757	115	383	-	-	SYM
admet-757	115	384	33	33	NUM
admet-757	115	385	-	-	SYM
admet-757	115	386	9	9	NUM
admet-757	115	387	basic	basic	ADJ
admet-757	115	388	20.2	20.2	NUM
admet-757	115	389	-0.33	-0.33	PROPN
admet-757	115	390	nicardipine	nicardipine	NOUN
admet-757	115	391	55985	55985	NUM
admet-757	115	392	-	-	SYM
admet-757	115	393	32	32	NUM
admet-757	115	394	-	-	SYM
admet-757	115	395	5	5	NUM
admet-757	115	396	weak	weak	ADJ
admet-757	115	397	base	base	NOUN
admet-757	115	398	45.9	45.9	NUM
admet-757	115	399	0.47	0.47	NUM
admet-757	115	400	nifedipine	nifedipine	PROPN
admet-757	115	401	21829	21829	NUM
admet-757	115	402	-	-	SYM
admet-757	115	403	25	25	NUM
admet-757	115	404	-	-	SYM
admet-757	115	405	4	4	NUM
admet-757	115	406	neutral	neutral	ADJ
admet-757	115	407	29.0	29.0	NUM
admet-757	115	408	-0.04	-0.04	NUM
admet-757	115	409	nitrendipine	nitrendipine	ADJ
admet-757	115	410	39562	39562	NUM
admet-757	115	411	-	-	SYM
admet-757	115	412	70	70	NUM
admet-757	115	413	-	-	SYM
admet-757	115	414	4	4	NUM
admet-757	115	415	neutral	neutral	ADJ
admet-757	115	416	40.5	40.5	NUM
admet-757	115	417	0.16	0.16	NUM
admet-757	115	418	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	116	1	klara	klara	PROPN
admet-757	116	2	valko	valko	PROPN
admet-757	116	3	et	et	PROPN
admet-757	116	4	al	al	PROPN
admet-757	116	5	.	.	PROPN
admet-757	116	6	admet	admet	PROPN
admet-757	116	7	&	&	CCONJ
admet-757	116	8	dmpk	dmpk	PROPN
admet-757	116	9	8(1	8(1	NOUN
admet-757	116	10	)	)	PUNCT
admet-757	116	11	(	(	PUNCT
admet-757	116	12	2020	2020	NUM
admet-757	116	13	)	)	PUNCT
admet-757	116	14	78	78	NUM
admet-757	116	15	-	-	SYM
admet-757	116	16	97	97	NUM
admet-757	116	17	84	84	NUM
admet-757	116	18	papaverine	papaverine	VERB
admet-757	116	19	58	58	NUM
admet-757	116	20	-	-	SYM
admet-757	116	21	74	74	NUM
admet-757	116	22	-	-	SYM
admet-757	116	23	2	2	NUM
admet-757	116	24	weak	weak	ADJ
admet-757	116	25	base	base	NOUN
admet-757	116	26	34.4	34.4	NUM
admet-757	116	27	0.00	0.00	NUM
admet-757	116	28	pentoxifylline	pentoxifylline	NOUN
admet-757	116	29	6493	6493	NUM
admet-757	116	30	-	-	SYM
admet-757	116	31	05	05	NUM
admet-757	116	32	-	-	PUNCT
admet-757	116	33	6	6	NUM
admet-757	116	34	.	.	PUNCT
admet-757	117	1	neutral	neutral	ADJ
admet-757	117	2	12.0	12.0	NUM
admet-757	117	3	-0.10	-0.10	NUM
admet-757	117	4	perphenazine	perphenazine	ADJ
admet-757	117	5	58	58	NUM
admet-757	117	6	-	-	SYM
admet-757	117	7	39	39	NUM
admet-757	117	8	-	-	SYM
admet-757	117	9	9	9	NUM
admet-757	117	10	basic	basic	ADJ
admet-757	117	11	56.3	56.3	NUM
admet-757	117	12	1.35	1.35	NUM
admet-757	117	13	phenytoin	phenytoin	NOUN
admet-757	117	14	57	57	NUM
admet-757	117	15	-	-	SYM
admet-757	117	16	41	41	NUM
admet-757	117	17	-	-	PUNCT
admet-757	117	18	0	0	NUM
admet-757	117	19	weak	weak	ADJ
admet-757	117	20	acid	acid	NOUN
admet-757	117	21	31.6	31.6	NUM
admet-757	117	22	0.03	0.03	NUM
admet-757	117	23	pindolol	pindolol	NOUN
admet-757	117	24	13523	13523	NUM
admet-757	117	25	-	-	SYM
admet-757	117	26	86	86	NUM
admet-757	117	27	-	-	SYM
admet-757	117	28	9	9	NUM
admet-757	117	29	basic	basic	ADJ
admet-757	117	30	42.0	42.0	NUM
admet-757	117	31	0.85	0.85	NUM
admet-757	117	32	prazosin	prazosin	NOUN
admet-757	117	33	19216	19216	NUM
admet-757	117	34	-	-	SYM
admet-757	117	35	56	56	NUM
admet-757	117	36	-	-	SYM
admet-757	117	37	9	9	NUM
admet-757	117	38	weak	weak	ADJ
admet-757	117	39	base	base	NOUN
admet-757	117	40	31.6	31.6	NUM
admet-757	117	41	-0.05	-0.05	NOUN
admet-757	117	42	prednisolone	prednisolone	PROPN
admet-757	117	43	50	50	NUM
admet-757	117	44	-	-	PUNCT
admet-757	117	45	24	24	NUM
admet-757	117	46	-	-	PUNCT
admet-757	117	47	8	8	NUM
admet-757	117	48	neutral	neutral	ADJ
admet-757	117	49	28.0	28.0	NUM
admet-757	117	50	0.14	0.14	NUM
admet-757	117	51	prednisone	prednisone	PROPN
admet-757	117	52	53	53	NUM
admet-757	117	53	-	-	PUNCT
admet-757	117	54	03	03	NUM
admet-757	117	55	-	-	PUNCT
admet-757	117	56	2	2	NUM
admet-757	117	57	neutral	neutral	ADJ
admet-757	117	58	25.9	25.9	NUM
admet-757	117	59	0.05	0.05	NUM
admet-757	117	60	primidone	primidone	NOUN
admet-757	117	61	125	125	NUM
admet-757	117	62	-	-	SYM
admet-757	117	63	33	33	NUM
admet-757	117	64	-	-	SYM
admet-757	117	65	7	7	NUM
admet-757	117	66	neutral	neutral	ADJ
admet-757	117	67	8.9	8.9	NUM
admet-757	117	68	-0.15	-0.15	NUM
admet-757	117	69	probenecid	probenecid	PROPN
admet-757	117	70	57	57	NUM
admet-757	117	71	-	-	SYM
admet-757	117	72	66	66	NUM
admet-757	117	73	-	-	PUNCT
admet-757	117	74	9	9	NUM
admet-757	117	75	acidic	acidic	ADJ
admet-757	117	76	20.1	20.1	NUM
admet-757	117	77	-0.75	-0.75	NUM
admet-757	117	78	procainamide	procainamide	NOUN
admet-757	117	79	614	614	NUM
admet-757	117	80	-	-	SYM
admet-757	117	81	39	39	NUM
admet-757	117	82	-	-	SYM
admet-757	117	83	1	1	NUM
admet-757	117	84	basic	basic	ADJ
admet-757	117	85	19.9	19.9	NUM
admet-757	117	86	0.02	0.02	NUM
admet-757	117	87	propanolol	propanolol	NOUN
admet-757	117	88	525	525	NUM
admet-757	117	89	-	-	PUNCT
admet-757	117	90	66	66	NUM
admet-757	117	91	-	-	SYM
admet-757	117	92	6	6	NUM
admet-757	117	93	basic	basic	ADJ
admet-757	117	94	50.8	50.8	NUM
admet-757	117	95	1.29	1.29	NUM
admet-757	117	96	propylthiouracil	propylthiouracil	NOUN
admet-757	117	97	51	51	NUM
admet-757	117	98	-	-	SYM
admet-757	117	99	52	52	NUM
admet-757	117	100	-	-	SYM
admet-757	117	101	5	5	NUM
admet-757	117	102	weak	weak	ADJ
admet-757	117	103	acid	acid	NOUN
admet-757	117	104	3.9	3.9	NUM
admet-757	117	105	-0.34	-0.34	NOUN
admet-757	117	106	proxyphylline	proxyphylline	NOUN
admet-757	117	107	603	603	NUM
admet-757	117	108	-	-	SYM
admet-757	117	109	00	00	NUM
admet-757	117	110	-	-	PUNCT
admet-757	117	111	9	9	NUM
admet-757	117	112	neutral	neutral	ADJ
admet-757	117	113	1.1	1.1	NUM
admet-757	117	114	-0.85	-0.85	NOUN
admet-757	117	115	sulfachlorpyridazine	sulfachlorpyridazine	NOUN
admet-757	117	116	80	80	NUM
admet-757	117	117	-	-	SYM
admet-757	117	118	32	32	NUM
admet-757	117	119	-	-	SYM
admet-757	117	120	0	0	NUM
admet-757	117	121	acidic	acidic	ADJ
admet-757	117	122	6.0	6.0	NUM
admet-757	117	123	-0.76	-0.76	NOUN
admet-757	117	124	sulfameter	sulfameter	NOUN
admet-757	117	125	651	651	NUM
admet-757	117	126	-	-	SYM
admet-757	117	127	06	06	NUM
admet-757	117	128	-	-	SYM
admet-757	117	129	9	9	NUM
admet-757	117	130	acidic	acidic	ADJ
admet-757	117	131	3.7	3.7	NUM
admet-757	117	132	-0.61	-0.61	NOUN
admet-757	117	133	sulfamethoxypyridazine	sulfamethoxypyridazine	NOUN
admet-757	117	134	80	80	NUM
admet-757	117	135	-	-	SYM
admet-757	117	136	35	35	NUM
admet-757	117	137	-	-	SYM
admet-757	117	138	3	3	NUM
admet-757	117	139	weak	weak	ADJ
admet-757	117	140	acid	acid	NOUN
admet-757	117	141	9.6	9.6	NUM
admet-757	117	142	-0.59	-0.59	NUM
admet-757	117	143	sulfinpyrazone	sulfinpyrazone	NOUN
admet-757	117	144	57	57	NUM
admet-757	117	145	-	-	SYM
admet-757	117	146	96	96	NUM
admet-757	117	147	-	-	SYM
admet-757	117	148	5	5	NUM
admet-757	117	149	acidic	acidic	ADJ
admet-757	117	150	26.1	26.1	NUM
admet-757	117	151	-0.65	-0.65	NUM
admet-757	117	152	sulfisoxazole	sulfisoxazole	ADJ
admet-757	117	153	127	127	NUM
admet-757	117	154	-	-	SYM
admet-757	117	155	69	69	NUM
admet-757	117	156	-	-	SYM
admet-757	117	157	5	5	NUM
admet-757	117	158	acidic	acidic	ADJ
admet-757	117	159	2.9	2.9	NUM
admet-757	117	160	-0.72	-0.72	NOUN
admet-757	117	161	sulphadimidine	sulphadimidine	NOUN
admet-757	117	162	57	57	NUM
admet-757	117	163	-	-	SYM
admet-757	117	164	68	68	NUM
admet-757	117	165	-	-	SYM
admet-757	117	166	1	1	NUM
admet-757	117	167	amphoteric	amphoteric	ADJ
admet-757	117	168	34.6	34.6	NUM
admet-757	117	169	0.22	0.22	NUM
admet-757	117	170	sulpiride	sulpiride	NOUN
admet-757	117	171	15676	15676	NUM
admet-757	117	172	-	-	SYM
admet-757	117	173	16	16	NUM
admet-757	117	174	-	-	SYM
admet-757	117	175	1	1	NUM
admet-757	117	176	basic	basic	ADJ
admet-757	117	177	25.5	25.5	NUM
admet-757	117	178	0.12	0.12	NUM
admet-757	117	179	tamoxifen	tamoxifen	PROPN
admet-757	117	180	10540	10540	NUM
admet-757	117	181	-	-	SYM
admet-757	117	182	29	29	NUM
admet-757	117	183	-	-	SYM
admet-757	117	184	1	1	NUM
admet-757	117	185	basic	basic	ADJ
admet-757	117	186	58.7	58.7	NUM
admet-757	117	187	1.48	1.48	NUM
admet-757	117	188	theobromine	theobromine	NUM
admet-757	117	189	83	83	NUM
admet-757	117	190	-	-	SYM
admet-757	117	191	67	67	NUM
admet-757	117	192	-	-	PUNCT
admet-757	117	193	0	0	NUM
admet-757	117	194	weak	weak	ADJ
admet-757	117	195	acid	acid	NOUN
admet-757	117	196	-4.1	-4.1	PUNCT
admet-757	117	197	-0.25	-0.25	NUM
admet-757	117	198	tolfenamic	tolfenamic	ADJ
admet-757	117	199	acid	acid	NOUN
admet-757	117	200	13710	13710	NUM
admet-757	117	201	-	-	SYM
admet-757	117	202	19	19	NUM
admet-757	117	203	-	-	SYM
admet-757	117	204	5	5	NUM
admet-757	117	205	acidic	acidic	ADJ
admet-757	117	206	36.6	36.6	NUM
admet-757	117	207	-0.76	-0.76	NUM
admet-757	117	208	trazodone	trazodone	PROPN
admet-757	117	209	19794	19794	NUM
admet-757	117	210	-	-	SYM
admet-757	117	211	93	93	NUM
admet-757	117	212	-	-	SYM
admet-757	117	213	5	5	NUM
admet-757	117	214	weak	weak	ADJ
admet-757	117	215	base	base	NOUN
admet-757	117	216	36.3	36.3	NUM
admet-757	117	217	0.01	0.01	NUM
admet-757	117	218	trimethoprim	trimethoprim	NOUN
admet-757	117	219	738	738	NUM
admet-757	117	220	-	-	SYM
admet-757	117	221	70	70	NUM
admet-757	117	222	-	-	SYM
admet-757	117	223	5	5	NUM
admet-757	117	224	weak	weak	ADJ
admet-757	117	225	base	base	NOUN
admet-757	117	226	20.8	20.8	NUM
admet-757	117	227	-0.06	-0.06	NUM
admet-757	117	228	warfarin	warfarin	NOUN
admet-757	117	229	81	81	NUM
admet-757	117	230	-	-	PUNCT
admet-757	117	231	81	81	NUM
admet-757	117	232	-	-	PUNCT
admet-757	117	233	2	2	NUM
admet-757	117	234	acidic	acidic	ADJ
admet-757	117	235	19.9	19.9	NUM
admet-757	117	236	-0.78	-0.78	NOUN
admet-757	117	237	table	table	NOUN
admet-757	117	238	3	3	NUM
admet-757	117	239	.	.	PUNCT
admet-757	118	1	the	the	DET
admet-757	118	2	chi	chi	PROPN
admet-757	118	3	(	(	PUNCT
admet-757	118	4	iam	iam	PROPN
admet-757	118	5	)	)	PUNCT
admet-757	118	6	obtained	obtain	VERB
admet-757	118	7	from	from	ADP
admet-757	118	8	the	the	DET
admet-757	118	9	literature	literature	NOUN
admet-757	118	10	[	[	X
admet-757	118	11	13	13	NUM
admet-757	118	12	]	]	PUNCT
admet-757	118	13	(	(	PUNCT
admet-757	118	14	chi	chi	NOUN
admet-757	118	15	(	(	PUNCT
admet-757	118	16	iam	iam	PROPN
admet-757	118	17	)	)	PUNCT
admet-757	118	18	reference	reference	NOUN
admet-757	118	19	)	)	PUNCT
admet-757	118	20	,	,	PUNCT
admet-757	118	21	the	the	DET
admet-757	118	22	chi	chi	NOUN
admet-757	118	23	(	(	PUNCT
admet-757	118	24	iam	iam	PROPN
admet-757	118	25	)	)	PUNCT
admet-757	118	26	values	value	NOUN
admet-757	118	27	obtained	obtain	VERB
admet-757	118	28	on	on	ADP
admet-757	118	29	the	the	DET
admet-757	118	30	new	new	ADJ
admet-757	118	31	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	118	32	columns	column	NOUN
admet-757	118	33	and	and	CCONJ
admet-757	118	34	the	the	DET
admet-757	118	35	acid	acid	NOUN
admet-757	118	36	/	/	SYM
admet-757	118	37	base	base	NOUN
admet-757	118	38	character	character	NOUN
admet-757	118	39	of	of	ADP
admet-757	118	40	the	the	DET
admet-757	118	41	iam	iam	PROPN
admet-757	118	42	calibration	calibration	NOUN
admet-757	118	43	compounds	compound	VERB
admet-757	118	44	compound	compound	NOUN
admet-757	118	45	acid	acid	NOUN
admet-757	118	46	/	/	SYM
admet-757	118	47	base	base	NOUN
admet-757	118	48	character	character	NOUN
admet-757	118	49	chi	chi	NOUN
admet-757	118	50	(	(	PUNCT
admet-757	118	51	iam	iam	PROPN
admet-757	118	52	)	)	PUNCT
admet-757	118	53	chi	chi	NOUN
admet-757	118	54	(	(	PUNCT
admet-757	118	55	iam	iam	PROPN
admet-757	118	56	)	)	PUNCT
admet-757	118	57	“	"	PUNCT
admet-757	118	58	new	new	ADJ
admet-757	118	59	”	"	PUNCT
admet-757	118	60	carbamazepine	carbamazepine	NOUN
admet-757	118	61	neutral	neutral	ADJ
admet-757	118	62	28.9	28.9	NUM
admet-757	118	63	27.0	27.0	NUM
admet-757	118	64	colchicine	colchicine	NOUN
admet-757	118	65	neutral	neutral	ADJ
admet-757	118	66	23.7	23.7	NUM
admet-757	118	67	23.0	23.0	NUM
admet-757	118	68	warfarin	warfarin	NOUN
admet-757	118	69	acidic	acidic	ADJ
admet-757	118	70	19.9	19.9	NUM
admet-757	118	71	24.0	24.0	NUM
admet-757	118	72	indomethacin	indomethacin	NOUN
admet-757	118	73	acidic	acidic	ADJ
admet-757	118	74	32.5	32.5	NUM
admet-757	118	75	30.0	30.0	NUM
admet-757	118	76	nicardipine	nicardipine	NOUN
admet-757	118	77	weak	weak	ADJ
admet-757	118	78	base	base	NOUN
admet-757	118	79	45.9	45.9	NUM
admet-757	118	80	45.0	45.0	NUM
admet-757	118	81	propranolol	propranolol	NOUN
admet-757	118	82	basic	basic	ADJ
admet-757	118	83	45.1	45.1	NUM
admet-757	118	84	42.0	42.0	NUM
admet-757	118	85	imipramine	imipramine	ADJ
admet-757	118	86	basic	basic	ADJ
admet-757	118	87	54.1	54.1	NUM
admet-757	118	88	45.0	45.0	NUM
admet-757	118	89	ketoprofen	ketoprofen	NOUN
admet-757	118	90	strong	strong	ADJ
admet-757	118	91	acid	acid	NOUN
admet-757	118	92	21.9	21.9	NUM
admet-757	118	93	20.0	20.0	NUM
admet-757	118	94	chlorpromazine	chlorpromazine	NOUN
admet-757	118	95	basic	basic	ADJ
admet-757	118	96	61.9	61.9	NUM
admet-757	118	97	54.0	54.0	NUM
admet-757	118	98	haloperidol	haloperidol	VERB
admet-757	118	99	basic	basic	ADJ
admet-757	118	100	44.3	44.3	NUM
admet-757	118	101	48	48	NUM
admet-757	118	102	budesonide	budesonide	NOUN
admet-757	118	103	neutral	neutral	ADJ
admet-757	118	104	38.7	38.7	NUM
admet-757	118	105	38	38	NUM
admet-757	118	106	figure	figure	NOUN
admet-757	118	107	2	2	NUM
admet-757	118	108	shows	show	VERB
admet-757	118	109	the	the	DET
admet-757	118	110	plot	plot	NOUN
admet-757	118	111	of	of	ADP
admet-757	118	112	the	the	DET
admet-757	118	113	experimental	experimental	ADJ
admet-757	118	114	chi	chi	NOUN
admet-757	118	115	(	(	PUNCT
admet-757	118	116	iam	iam	PROPN
admet-757	118	117	)	)	PUNCT
admet-757	118	118	values	value	NOUN
admet-757	118	119	on	on	ADP
admet-757	118	120	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	118	121	columns	column	NOUN
admet-757	118	122	p20511	p20511	NOUN
admet-757	118	123	-	-	PUNCT
admet-757	118	124	014	014	NUM
admet-757	118	125	-	-	PUNCT
admet-757	118	126	3	3	NUM
admet-757	118	127	and	and	CCONJ
admet-757	118	128	r2055	r2055	NOUN
admet-757	118	129	-	-	PUNCT
admet-757	118	130	014	014	NUM
admet-757	118	131	-	-	SYM
admet-757	118	132	3	3	NUM
admet-757	118	133	.	.	PUNCT
admet-757	119	1	the	the	DET
admet-757	119	2	chi	chi	PROPN
admet-757	119	3	(	(	PUNCT
admet-757	119	4	iam	iam	PROPN
admet-757	119	5	)	)	PUNCT
admet-757	119	6	values	value	NOUN
admet-757	119	7	obtained	obtain	VERB
admet-757	119	8	on	on	ADP
admet-757	119	9	the	the	DET
admet-757	119	10	columns	column	NOUN
admet-757	119	11	are	be	AUX
admet-757	119	12	very	very	ADV
admet-757	119	13	similar	similar	ADJ
admet-757	119	14	indicating	indicate	VERB
admet-757	119	15	good	good	ADJ
admet-757	119	16	batch	batch	NOUN
admet-757	119	17	to	to	PART
admet-757	119	18	batch	batch	VERB
admet-757	119	19	reproducibility	reproducibility	NOUN
admet-757	119	20	of	of	ADP
admet-757	119	21	the	the	DET
admet-757	119	22	new	new	ADJ
admet-757	119	23	columns	column	NOUN
admet-757	119	24	.	.	PUNCT
admet-757	120	1	admet	admet	PROPN
admet-757	120	2	&	&	CCONJ
admet-757	120	3	dmpk	dmpk	PROPN
admet-757	120	4	8(1	8(1	NOUN
admet-757	120	5	)	)	PUNCT
admet-757	120	6	(	(	PUNCT
admet-757	120	7	2020	2020	NUM
admet-757	120	8	)	)	PUNCT
admet-757	120	9	78	78	NUM
admet-757	120	10	-	-	SYM
admet-757	120	11	97	97	NUM
admet-757	120	12	revisiting	revisit	VERB
admet-757	120	13	the	the	DET
admet-757	120	14	iam	iam	PROPN
admet-757	120	15	chromatography	chromatography	NOUN
admet-757	120	16	doi	doi	PROPN
admet-757	120	17	:	:	PUNCT
admet-757	120	18	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	120	19	85	85	NUM
admet-757	120	20	table	table	NOUN
admet-757	120	21	4	4	NUM
admet-757	120	22	.	.	PUNCT
admet-757	121	1	the	the	DET
admet-757	121	2	experimental	experimental	ADJ
admet-757	121	3	chi	chi	NOUN
admet-757	121	4	(	(	PUNCT
admet-757	121	5	iam	iam	PROPN
admet-757	121	6	)	)	PUNCT
admet-757	121	7	values	value	NOUN
admet-757	121	8	of	of	ADP
admet-757	121	9	the	the	DET
admet-757	121	10	investigated	investigate	VERB
admet-757	121	11	compounds	compound	NOUN
admet-757	121	12	obtained	obtain	VERB
admet-757	121	13	on	on	ADP
admet-757	121	14	the	the	DET
admet-757	121	15	new	new	ADJ
admet-757	121	16	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	121	17	columns	column	NOUN
admet-757	121	18	and	and	CCONJ
admet-757	121	19	the	the	DET
admet-757	121	20	chi	chi	NOUN
admet-757	121	21	(	(	PUNCT
admet-757	121	22	iam	iam	PROPN
admet-757	121	23	)	)	PUNCT
admet-757	121	24	obtained	obtain	VERB
admet-757	121	25	from	from	ADP
admet-757	121	26	the	the	DET
admet-757	121	27	literature	literature	NOUN
admet-757	121	28	[	[	X
admet-757	121	29	13	13	NUM
admet-757	121	30	]	]	PUNCT
admet-757	121	31	(	(	PUNCT
admet-757	121	32	reference	reference	NOUN
admet-757	121	33	chi	chi	NOUN
admet-757	121	34	(	(	PUNCT
admet-757	121	35	iam	iam	PROPN
admet-757	121	36	)	)	PUNCT
admet-757	121	37	)	)	PUNCT
admet-757	121	38	compound	compound	NOUN
admet-757	121	39	chi	chi	NOUN
admet-757	121	40	(	(	PUNCT
admet-757	121	41	iam	iam	PROPN
admet-757	121	42	)	)	PUNCT
admet-757	121	43	from	from	ADP
admet-757	121	44	ref	ref	NOUN
admet-757	121	45	[	[	X
admet-757	121	46	13	13	NUM
admet-757	121	47	]	]	X
admet-757	121	48	r20511	r20511	NUM
admet-757	121	49	-	-	PUNCT
admet-757	121	50	014	014	NUM
admet-757	121	51	-	-	PUNCT
admet-757	121	52	3	3	NUM
admet-757	121	53	chi	chi	NOUN
admet-757	121	54	(	(	PUNCT
admet-757	121	55	iam	iam	PROPN
admet-757	121	56	)	)	PUNCT
admet-757	121	57	p20511	p20511	NOUN
admet-757	121	58	-	-	PUNCT
admet-757	121	59	014	014	NUM
admet-757	121	60	-	-	SYM
admet-757	121	61	3	3	NUM
admet-757	121	62	chi	chi	NOUN
admet-757	121	63	(	(	PUNCT
admet-757	121	64	iam	iam	PROPN
admet-757	121	65	)	)	PUNCT
admet-757	121	66	log	log	NOUN
admet-757	121	67	k	k	PROPN
admet-757	121	68	hsa	hsa	PROPN
admet-757	121	69	from	from	ADP
admet-757	121	70	ref	ref	NOUN
admet-757	121	71	[	[	X
admet-757	121	72	13	13	NUM
admet-757	121	73	]	]	X
admet-757	121	74	log	log	NOUN
admet-757	121	75	k	k	PROPN
admet-757	121	76	hsa	hsa	PROPN
admet-757	121	77	acecainide	acecainide	ADV
admet-757	121	78	23.30	23.30	NUM
admet-757	121	79	17.72	17.72	NUM
admet-757	121	80	17.57	17.57	NUM
admet-757	121	81	0.69	0.69	NUM
admet-757	121	82	0.52	0.52	NUM
admet-757	121	83	acetanilide	acetanilide	ADP
admet-757	121	84	10.70	10.70	NUM
admet-757	121	85	11.55	11.55	NUM
admet-757	121	86	11.50	11.50	NUM
admet-757	121	87	0.62	0.62	NUM
admet-757	121	88	0.43	0.43	NUM
admet-757	121	89	acetazolamide	acetazolamide	ADV
admet-757	121	90	1.66	1.66	NUM
admet-757	121	91	0.99	0.99	NUM
admet-757	121	92	0.74	0.74	NUM
admet-757	121	93	1.47	1.47	NUM
admet-757	121	94	1.44	1.44	NUM
admet-757	121	95	alclofenac	alclofenac	ADJ
admet-757	121	96	17.80	17.80	NUM
admet-757	121	97	20.47	20.47	NUM
admet-757	121	98	21.63	21.63	NUM
admet-757	121	99	5.11	5.11	NUM
admet-757	121	100	5.40	5.40	NUM
admet-757	121	101	amoxapine	amoxapine	NOUN
admet-757	121	102	56.50	56.50	NUM
admet-757	121	103	45.41	45.41	NUM
admet-757	121	104	44.74	44.74	NUM
admet-757	121	105	2.15	2.15	NUM
admet-757	121	106	2.70	2.70	NUM
admet-757	121	107	bamethan	bamethan	NOUN
admet-757	121	108	18.60	18.60	NUM
admet-757	121	109	18.53	18.53	NUM
admet-757	121	110	18.03	18.03	NUM
admet-757	121	111	0.49	0.49	NUM
admet-757	121	112	0.42	0.42	NUM
admet-757	121	113	betamethasone	betamethasone	NOUN
admet-757	121	114	31.70	31.70	NUM
admet-757	121	115	30.18	30.18	NUM
admet-757	121	116	30.05	30.05	NUM
admet-757	121	117	1.09	1.09	NUM
admet-757	121	118	1.39	1.39	NUM
admet-757	121	119	carbamazepine	carbamazepine	NOUN
admet-757	121	120	26.50	26.50	NUM
admet-757	121	121	27.18	27.18	NUM
admet-757	121	122	27.07	27.07	NUM
admet-757	121	123	1.99	1.99	NUM
admet-757	121	124	1.81	1.81	NUM
admet-757	121	125	chlorpromazine	chlorpromazine	NOUN
admet-757	121	126	61.90	61.90	NUM
admet-757	121	127	51.54	51.54	NUM
admet-757	121	128	50.94	50.94	NUM
admet-757	121	129	1.18	1.18	NUM
admet-757	121	130	1.27	1.27	NUM
admet-757	121	131	cinoxacin	cinoxacin	NOUN
admet-757	121	132	1.60	1.60	NUM
admet-757	121	133	5.31	5.31	NUM
admet-757	121	134	6.67	6.67	NUM
admet-757	121	135	0.79	0.79	NUM
admet-757	121	136	0.91	0.91	NUM
admet-757	121	137	colchicine	colchicine	PROPN
admet-757	121	138	23.70	23.70	NUM
admet-757	121	139	23.45	23.45	NUM
admet-757	121	140	23.18	23.18	NUM
admet-757	121	141	0.69	0.69	NUM
admet-757	121	142	0.24	0.24	NUM
admet-757	121	143	cytarabine	cytarabine	NOUN
admet-757	121	144	-15.00	-15.00	PROPN
admet-757	121	145	-6.76	-6.76	PROPN
admet-757	121	146	-6.99	-6.99	NOUN
admet-757	121	147	1.59	1.59	NUM
admet-757	121	148	1.87	1.87	NUM
admet-757	121	149	diazoxide	diazoxide	NOUN
admet-757	121	150	24.70	24.70	NUM
admet-757	121	151	23.39	23.39	NUM
admet-757	121	152	23.44	23.44	NUM
admet-757	121	153	5.42	5.42	NUM
admet-757	121	154	5.58	5.58	NUM
admet-757	121	155	diclofenac	diclofenac	NOUN
admet-757	121	156	33.50	33.50	NUM
admet-757	121	157	35.18	35.18	NUM
admet-757	121	158	35.85	35.85	NUM
admet-757	121	159	0.63	0.63	NUM
admet-757	121	160	0.24	0.24	NUM
admet-757	121	161	diprophylline	diprophylline	NOUN
admet-757	121	162	-4.00	-4.00	NUM
admet-757	121	163	-1.49	-1.49	NOUN
admet-757	121	164	-1.98	-1.98	CCONJ
admet-757	121	165	4.1	4.1	NUM
admet-757	121	166	4.24	4.24	NUM
admet-757	121	167	ethinyl	ethinyl	NOUN
admet-757	121	168	estradiol	estradiol	PROPN
admet-757	121	169	46.80	46.80	NUM
admet-757	121	170	45.30	45.30	NUM
admet-757	121	171	45.23	45.23	NUM
admet-757	121	172	0.46	0.46	NUM
admet-757	121	173	0.50	0.50	NUM
admet-757	121	174	famotidine	famotidine	NOUN
admet-757	121	175	15.70	15.70	NUM
admet-757	121	176	16.82	16.82	NUM
admet-757	121	177	16.08	16.08	NUM
admet-757	121	178	1.39	1.39	NUM
admet-757	121	179	3.43	3.43	NUM
admet-757	121	180	felbamate	felbamate	NOUN
admet-757	121	181	19.07	19.07	NUM
admet-757	121	182	39.16	39.16	NUM
admet-757	121	183	39.21	39.21	NUM
admet-757	121	184	3.46	3.46	NUM
admet-757	121	185	4.15	4.15	NUM
admet-757	121	186	felodipine	felodipine	NOUN
admet-757	121	187	46.10	46.10	NUM
admet-757	121	188	44.37	44.37	NUM
admet-757	121	189	44.45	44.45	NUM
admet-757	121	190	5.91	5.91	NUM
admet-757	121	191	6.11	6.11	NUM
admet-757	121	192	fenoprofen	fenoprofen	VERB
admet-757	121	193	17.20	17.20	NUM
admet-757	121	194	27.17	27.17	NUM
admet-757	121	195	28.26	28.26	NUM
admet-757	121	196	1.58	1.58	NUM
admet-757	121	197	2.32	2.32	NUM
admet-757	121	198	finasteride	finasteride	NOUN
admet-757	121	199	38.90	38.90	NUM
admet-757	121	200	37.15	37.15	NUM
admet-757	121	201	37.17	37.17	NUM
admet-757	121	202	3.62	3.62	NUM
admet-757	121	203	3.55	3.55	NUM
admet-757	121	204	floxacillin	floxacillin	NOUN
admet-757	121	205	23.40	23.40	NUM
admet-757	121	206	23.76	23.76	NUM
admet-757	121	207	24.59	24.59	NUM
admet-757	121	208	0.56	0.56	NUM
admet-757	121	209	0.65	0.65	NUM
admet-757	121	210	flumazenil	flumazenil	NOUN
admet-757	121	211	18.40	18.40	NUM
admet-757	121	212	18.27	18.27	NUM
admet-757	121	213	18.27	18.27	NUM
admet-757	121	214	7.81	7.81	NUM
admet-757	121	215	8.50	8.50	NUM
admet-757	121	216	flurbiprofen	flurbiprofen	VERB
admet-757	121	217	26.80	26.80	NUM
admet-757	121	218	30.23	30.23	NUM
admet-757	121	219	30.89	30.89	NUM
admet-757	121	220	1.26	1.26	NUM
admet-757	121	221	4.01	4.01	NUM
admet-757	121	222	furosemide	furosemide	ADV
admet-757	121	223	21.41	21.41	NUM
admet-757	121	224	21.96	21.96	NUM
admet-757	121	225	22.69	22.69	NUM
admet-757	121	226	3.64	3.64	NUM
admet-757	121	227	8.50	8.50	NUM
admet-757	121	228	gemfibrozil	gemfibrozil	NOUN
admet-757	121	229	32.90	32.90	NUM
admet-757	121	230	33.70	33.70	NUM
admet-757	121	231	34.53	34.53	NUM
admet-757	121	232	3.32	3.32	NUM
admet-757	121	233	4.05	4.05	NUM
admet-757	121	234	glipizide	glipizide	NOUN
admet-757	121	235	21.10	21.10	NUM
admet-757	121	236	22.82	22.82	NUM
admet-757	121	237	23.22	23.22	NUM
admet-757	121	238	1.49	1.49	NUM
admet-757	121	239	1.92	1.92	NUM
admet-757	121	240	griseofulvin	griseofulvin	NOUN
admet-757	121	241	33.10	33.10	NUM
admet-757	121	242	31.06	31.06	NUM
admet-757	121	243	30.98	30.98	NUM
admet-757	121	244	0.77	0.77	NUM
admet-757	121	245	0.80	0.80	NUM
admet-757	121	246	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-757	121	247	15.90	15.90	NUM
admet-757	121	248	13.04	13.04	NUM
admet-757	121	249	13.08	13.08	NUM
admet-757	121	250	0.92	0.92	NUM
admet-757	121	251	1.05	1.05	NUM
admet-757	121	252	hydrocortisone	hydrocortisone	NOUN
admet-757	121	253	27.90	27.90	NUM
admet-757	121	254	27.23	27.23	NUM
admet-757	121	255	27.02	27.02	NUM
admet-757	121	256	1.95	1.95	NUM
admet-757	121	257	2.59	2.59	NUM
admet-757	121	258	imipramine	imipramine	ADJ
admet-757	121	259	51.60	51.60	NUM
admet-757	121	260	45.58	45.58	NUM
admet-757	121	261	44.81	44.81	NUM
admet-757	121	262	6.17	6.17	NUM
admet-757	121	263	5.59	5.59	NUM
admet-757	121	264	indomethacin	indomethacin	VERB
admet-757	121	265	25.30	25.30	NUM
admet-757	121	266	32.49	32.49	NUM
admet-757	121	267	33.16	33.16	NUM
admet-757	121	268	2.86	2.86	NUM
admet-757	121	269	3.36	3.36	NUM
admet-757	121	270	isradipine	isradipine	NOUN
admet-757	121	271	40.00	40.00	NUM
admet-757	121	272	39.11	39.11	NUM
admet-757	121	273	39.16	39.16	NUM
admet-757	121	274	2.9	2.9	NUM
admet-757	121	275	3.30	3.30	NUM
admet-757	121	276	ketoconazole	ketoconazole	NOUN
admet-757	121	277	42.90	42.90	NUM
admet-757	121	278	39.50	39.50	NUM
admet-757	121	279	39.26	39.26	NUM
admet-757	121	280	4.8	4.8	NUM
admet-757	121	281	5.40	5.40	NUM
admet-757	121	282	ketoprofen	ketoprofen	NOUN
admet-757	121	283	21.90	21.90	NUM
admet-757	121	284	22.93	22.93	NUM
admet-757	121	285	23.89	23.89	NUM
admet-757	121	286	1.28	1.28	NUM
admet-757	121	287	1.80	1.80	NUM
admet-757	121	288	labetalol	labetalol	NOUN
admet-757	121	289	43.90	43.90	NUM
admet-757	121	290	38.29	38.29	NUM
admet-757	121	291	37.48	37.48	NUM
admet-757	121	292	0.69	0.69	NUM
admet-757	121	293	0.52	0.52	NUM
admet-757	121	294	lignocaine	lignocaine	NOUN
admet-757	121	295	32.60	32.60	NUM
admet-757	121	296	24.89	24.89	NUM
admet-757	121	297	25.53	25.53	NUM
admet-757	121	298	1.35	1.35	NUM
admet-757	121	299	1.53	1.53	NUM
admet-757	121	300	methylprednisolone	methylprednisolone	NOUN
admet-757	121	301	32.10	32.10	NUM
admet-757	121	302	30.91	30.91	NUM
admet-757	121	303	30.77	30.77	NUM
admet-757	121	304	0.76	0.76	NUM
admet-757	121	305	0.28	0.28	NUM
admet-757	121	306	metronidazole	metronidazole	NOUN
admet-757	121	307	-3.30	-3.30	NOUN
admet-757	121	308	-2.71	-2.71	NUM
admet-757	121	309	-3.24	-3.24	NUM
admet-757	121	310	0.66	0.66	NUM
admet-757	121	311	0.72	0.72	NUM
admet-757	121	312	minoxidil	minoxidil	NOUN
admet-757	121	313	19.00	19.00	NUM
admet-757	121	314	15.93	15.93	NUM
admet-757	121	315	16.08	16.08	NUM
admet-757	121	316	3.16	3.16	NUM
admet-757	121	317	3.41	3.41	NUM
admet-757	121	318	nabumetone	nabumetone	NOUN
admet-757	121	319	38.40	38.40	NUM
admet-757	121	320	35.90	35.90	NUM
admet-757	121	321	35.96	35.96	NUM
admet-757	121	322	0.49	0.49	NUM
admet-757	121	323	2.14	2.14	NUM
admet-757	121	324	nadolol	nadolol	NOUN
admet-757	121	325	20.20	20.20	NUM
admet-757	121	326	19.89	19.89	NUM
admet-757	121	327	19.23	19.23	NUM
admet-757	121	328	2.93	2.93	NUM
admet-757	121	329	3.55	3.55	NUM
admet-757	121	330	nicardipine	nicardipine	NOUN
admet-757	121	331	45.90	45.90	NUM
admet-757	121	332	43.82	43.82	NUM
admet-757	121	333	43.73	43.73	NUM
admet-757	121	334	1.41	1.41	NUM
admet-757	121	335	1.95	1.95	NUM
admet-757	121	336	nifedipine	nifedipine	NOUN
admet-757	121	337	29.00	29.00	NUM
admet-757	121	338	28.11	28.11	NUM
admet-757	121	339	28.16	28.16	NUM
admet-757	121	340	3.13	3.13	NUM
admet-757	121	341	3.37	3.37	NUM
admet-757	121	342	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	122	1	klara	klara	PROPN
admet-757	122	2	valko	valko	PROPN
admet-757	122	3	et	et	PROPN
admet-757	122	4	al	al	PROPN
admet-757	122	5	.	.	PROPN
admet-757	122	6	admet	admet	PROPN
admet-757	122	7	&	&	CCONJ
admet-757	122	8	dmpk	dmpk	PROPN
admet-757	122	9	8(1	8(1	NOUN
admet-757	122	10	)	)	PUNCT
admet-757	122	11	(	(	PUNCT
admet-757	122	12	2020	2020	NUM
admet-757	122	13	)	)	PUNCT
admet-757	122	14	78	78	NUM
admet-757	122	15	-	-	SYM
admet-757	122	16	97	97	NUM
admet-757	122	17	86	86	NUM
admet-757	122	18	nitrendipine	nitrendipine	NOUN
admet-757	122	19	40.50	40.50	NUM
admet-757	122	20	39.06	39.06	NUM
admet-757	122	21	39.19	39.19	NUM
admet-757	122	22	2.35	2.35	NUM
admet-757	122	23	2.70	2.70	NUM
admet-757	122	24	papaverine	papaverine	NOUN
admet-757	122	25	34.40	34.40	NUM
admet-757	122	26	31.22	31.22	NUM
admet-757	122	27	31.15	31.15	NUM
admet-757	122	28	0.63	0.63	NUM
admet-757	122	29	0.39	0.39	NUM
admet-757	122	30	pentoxifylline	pentoxifylline	NOUN
admet-757	122	31	12.00	12.00	NUM
admet-757	122	32	14.04	14.04	NUM
admet-757	122	33	13.87	13.87	NUM
admet-757	122	34	3.27	3.27	NUM
admet-757	122	35	4.03	4.03	NUM
admet-757	122	36	perphenazine	perphenazine	ADJ
admet-757	122	37	56.30	56.30	NUM
admet-757	122	38	49.57	49.57	NUM
admet-757	122	39	48.97	48.97	NUM
admet-757	122	40	1.6	1.6	NUM
admet-757	122	41	2.02	2.02	NUM
admet-757	122	42	phenytoin	phenytoin	NOUN
admet-757	122	43	31.60	31.60	NUM
admet-757	122	44	30.18	30.18	NUM
admet-757	122	45	30.20	30.20	NUM
admet-757	122	46	0.54	0.54	NUM
admet-757	122	47	0.63	0.63	NUM
admet-757	122	48	pindolol	pindolol	NOUN
admet-757	122	49	42.00	42.00	NUM
admet-757	122	50	25.69	25.69	NUM
admet-757	122	51	25.31	25.31	NUM
admet-757	122	52	1.81	1.81	NUM
admet-757	122	53	2.40	2.40	NUM
admet-757	122	54	prazosin	prazosin	NOUN
admet-757	122	55	31.60	31.60	NUM
admet-757	122	56	29.82	29.82	NUM
admet-757	122	57	29.35	29.35	NUM
admet-757	122	58	0.89	0.89	NUM
admet-757	122	59	0.95	0.95	NUM
admet-757	122	60	prednisolone	prednisolone	PROPN
admet-757	122	61	28.00	28.00	NUM
admet-757	122	62	27.31	27.31	NUM
admet-757	122	63	27.20	27.20	NUM
admet-757	122	64	0.8	0.8	NUM
admet-757	122	65	1.08	1.08	NUM
admet-757	122	66	prednisone	prednisone	NOUN
admet-757	122	67	25.90	25.90	NUM
admet-757	122	68	25.25	25.25	NUM
admet-757	122	69	25.13	25.13	NUM
admet-757	122	70	0.62	0.62	NUM
admet-757	122	71	0.42	0.42	NUM
admet-757	122	72	primidone	primidone	NOUN
admet-757	122	73	8.90	8.90	NUM
admet-757	122	74	10.31	10.31	NUM
admet-757	122	75	10.49	10.49	NUM
admet-757	122	76	3.44	3.44	NUM
admet-757	122	77	4.01	4.01	NUM
admet-757	122	78	probenecid	probenecid	PROPN
admet-757	122	79	20.10	20.10	NUM
admet-757	122	80	23.45	23.45	NUM
admet-757	122	81	24.38	24.38	NUM
admet-757	122	82	0.76	0.76	NUM
admet-757	122	83	0.49	0.49	NUM
admet-757	122	84	procainamide	procainamide	ADJ
admet-757	122	85	19.90	19.90	NUM
admet-757	122	86	11.73	11.73	NUM
admet-757	122	87	11.89	11.89	NUM
admet-757	122	88	0.73	0.73	NUM
admet-757	122	89	1.67	1.67	NUM
admet-757	122	90	propranolol	propranolol	NOUN
admet-757	122	91	50.80	50.80	NUM
admet-757	122	92	42.24	42.24	NUM
admet-757	122	93	41.46	41.46	NUM
admet-757	122	94	0.63	0.63	NUM
admet-757	122	95	1.02	1.02	NUM
admet-757	122	96	propylthiouracil	propylthiouracil	NOUN
admet-757	122	97	3.90	3.90	NUM
admet-757	122	98	6.56	6.56	NUM
admet-757	122	99	6.52	6.52	NUM
admet-757	122	100	2.67	2.67	NUM
admet-757	122	101	3.21	3.21	NUM
admet-757	122	102	proxyphylline	proxyphylline	NOUN
admet-757	122	103	1.10	1.10	NUM
admet-757	122	104	10.05	10.05	NUM
admet-757	122	105	10.89	10.89	NUM
admet-757	122	106	1.97	1.97	NUM
admet-757	122	107	3.02	3.02	NUM
admet-757	122	108	sulfachlorpyridazine	sulfachlorpyridazine	NOUN
admet-757	122	109	6.00	6.00	NUM
admet-757	122	110	10.08	10.08	NUM
admet-757	122	111	10.83	10.83	NUM
admet-757	122	112	2.04	2.04	NUM
admet-757	122	113	2.20	2.20	NUM
admet-757	122	114	sulfameter	sulfameter	NOUN
admet-757	122	115	3.70	3.70	NUM
admet-757	122	116	6.92	6.92	NUM
admet-757	122	117	7.09	7.09	NUM
admet-757	122	118	4.09	4.09	NUM
admet-757	122	119	2.44	2.44	NUM
admet-757	122	120	sulfamethoxypyridazine	sulfamethoxypyridazine	NOUN
admet-757	122	121	9.60	9.60	NUM
admet-757	122	122	11.11	11.11	NUM
admet-757	122	123	11.16	11.16	NUM
admet-757	122	124	2.33	2.33	NUM
admet-757	122	125	4.27	4.27	NUM
admet-757	122	126	sulfinpyrazone	sulfinpyrazone	NOUN
admet-757	122	127	26.10	26.10	NUM
admet-757	122	128	26.19	26.19	NUM
admet-757	122	129	26.89	26.89	NUM
admet-757	122	130	3.17	3.17	NUM
admet-757	122	131	2.66	2.66	NUM
admet-757	122	132	sulfisoxazole	sulfisoxazole	NOUN
admet-757	122	133	2.90	2.90	NUM
admet-757	122	134	6.48	6.48	NUM
admet-757	122	135	7.37	7.37	NUM
admet-757	122	136	1.54	1.54	NUM
admet-757	122	137	3.68	3.68	NUM
admet-757	122	138	sulphadimidine	sulphadimidine	NOUN
admet-757	122	139	34.55	34.55	NUM
admet-757	122	140	10.89	10.89	NUM
admet-757	122	141	11.09	11.09	NUM
admet-757	122	142	0.75	0.75	NUM
admet-757	122	143	1.72	1.72	NUM
admet-757	122	144	sulpiride	sulpiride	NOUN
admet-757	122	145	25.50	25.50	NUM
admet-757	122	146	15.80	15.80	NUM
admet-757	122	147	16.15	16.15	NUM
admet-757	122	148	4.84	4.84	NUM
admet-757	122	149	0.71	0.71	NUM
admet-757	122	150	tamoxifen	tamoxifen	NOUN
admet-757	122	151	58.70	58.70	NUM
admet-757	122	152	54.23	54.23	NUM
admet-757	122	153	53.78	53.78	NUM
admet-757	122	154	1.29	1.29	NUM
admet-757	122	155	4.82	4.82	NUM
admet-757	122	156	theobromine	theobromine	X
admet-757	122	157	-4.10	-4.10	DET
admet-757	122	158	-3.16	-3.16	PROPN
admet-757	122	159	-3.71	-3.71	NUM
admet-757	122	160	4.68	4.68	NUM
admet-757	122	161	0.27	0.27	NUM
admet-757	122	162	tolfenamic	tolfenamic	ADJ
admet-757	122	163	acid	acid	NOUN
admet-757	122	164	36.60	36.60	NUM
admet-757	122	165	40.72	40.72	NUM
admet-757	122	166	41.53	41.53	NUM
admet-757	122	167	2.46	2.46	NUM
admet-757	122	168	6.60	6.60	NUM
admet-757	122	169	trazodone	trazodone	NOUN
admet-757	122	170	36.30	36.30	NUM
admet-757	122	171	34.09	34.09	NUM
admet-757	122	172	33.86	33.86	NUM
admet-757	122	173	0.8	0.8	NUM
admet-757	122	174	3.06	3.06	NUM
admet-757	122	175	trimethoprim	trimethoprim	NOUN
admet-757	122	176	20.80	20.80	NUM
admet-757	122	177	20.99	20.99	NUM
admet-757	122	178	20.52	20.52	NUM
admet-757	122	179	4.45	4.45	NUM
admet-757	122	180	0.95	0.95	NUM
admet-757	122	181	warfarin	warfarin	NOUN
admet-757	122	182	19.90	19.90	NUM
admet-757	122	183	23.47	23.47	NUM
admet-757	122	184	24.18	24.18	NUM
admet-757	122	185	0.7	0.7	NUM
admet-757	122	186	4.16	4.16	NUM
admet-757	122	187	figure	figure	NOUN
admet-757	122	188	3	3	NUM
admet-757	122	189	shows	show	VERB
admet-757	122	190	the	the	DET
admet-757	122	191	plot	plot	NOUN
admet-757	122	192	of	of	ADP
admet-757	122	193	the	the	DET
admet-757	122	194	chi	chi	NOUN
admet-757	122	195	(	(	PUNCT
admet-757	122	196	iam	iam	PROPN
admet-757	122	197	)	)	PUNCT
admet-757	122	198	from	from	ADP
admet-757	122	199	the	the	DET
admet-757	122	200	literature	literature	NOUN
admet-757	122	201	[	[	X
admet-757	122	202	13	13	NUM
admet-757	122	203	]	]	PUNCT
admet-757	122	204	,	,	PUNCT
admet-757	122	205	reference	reference	NOUN
admet-757	122	206	chi	chi	NOUN
admet-757	122	207	(	(	PUNCT
admet-757	122	208	iam	iam	PROPN
admet-757	122	209	)	)	PUNCT
admet-757	122	210	,	,	PUNCT
admet-757	122	211	with	with	ADP
admet-757	122	212	the	the	DET
admet-757	122	213	experimental	experimental	ADJ
admet-757	122	214	chi	chi	NOUN
admet-757	122	215	(	(	PUNCT
admet-757	122	216	iam	iam	PROPN
admet-757	122	217	)	)	PUNCT
admet-757	122	218	values	value	NOUN
admet-757	122	219	using	use	VERB
admet-757	122	220	the	the	DET
admet-757	122	221	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	122	222	column	column	NOUN
admet-757	122	223	r2055	r2055	NOUN
admet-757	122	224	-	-	PUNCT
admet-757	122	225	014	014	NUM
admet-757	122	226	-	-	SYM
admet-757	122	227	3	3	NUM
admet-757	122	228	.	.	PUNCT
admet-757	123	1	the	the	DET
admet-757	123	2	chi	chi	PROPN
admet-757	123	3	(	(	PUNCT
admet-757	123	4	iam	iam	PROPN
admet-757	123	5	)	)	PUNCT
admet-757	123	6	values	value	NOUN
admet-757	123	7	of	of	ADP
admet-757	123	8	procainamide	procainamide	ADJ
admet-757	123	9	,	,	PUNCT
admet-757	123	10	sulpiride	sulpiride	ADV
admet-757	123	11	,	,	PUNCT
admet-757	123	12	zolmitriptan	zolmitriptan	PROPN
admet-757	123	13	and	and	CCONJ
admet-757	123	14	pindolol	pindolol	NOUN
admet-757	123	15	were	be	AUX
admet-757	123	16	outliers	outlier	NOUN
admet-757	123	17	from	from	ADP
admet-757	123	18	the	the	DET
admet-757	123	19	correlation	correlation	NOUN
admet-757	123	20	with	with	ADP
admet-757	123	21	lower	low	ADJ
admet-757	123	22	chi	chi	NOUN
admet-757	123	23	(	(	PUNCT
admet-757	123	24	iam	iam	PROPN
admet-757	123	25	)	)	PUNCT
admet-757	123	26	values	value	NOUN
admet-757	123	27	on	on	ADP
admet-757	123	28	the	the	DET
admet-757	123	29	new	new	ADJ
admet-757	123	30	batches	batch	NOUN
admet-757	123	31	of	of	ADP
admet-757	123	32	iam	iam	PROPN
admet-757	123	33	columns	column	NOUN
admet-757	123	34	.	.	PUNCT
admet-757	124	1	compounds	compound	NOUN
admet-757	124	2	are	be	AUX
admet-757	124	3	considered	consider	VERB
admet-757	124	4	outliers	outlier	NOUN
admet-757	124	5	when	when	SCONJ
admet-757	124	6	the	the	DET
admet-757	124	7	difference	difference	NOUN
admet-757	124	8	between	between	ADP
admet-757	124	9	the	the	DET
admet-757	124	10	measured	measure	VERB
admet-757	124	11	and	and	CCONJ
admet-757	124	12	predicted	predict	VERB
admet-757	124	13	value	value	NOUN
admet-757	124	14	is	be	AUX
admet-757	124	15	greater	great	ADJ
admet-757	124	16	than	than	ADP
admet-757	124	17	the	the	DET
admet-757	124	18	double	double	NOUN
admet-757	124	19	of	of	ADP
admet-757	124	20	the	the	DET
admet-757	124	21	standard	standard	ADJ
admet-757	124	22	error	error	NOUN
admet-757	124	23	of	of	ADP
admet-757	124	24	the	the	DET
admet-757	124	25	estimate	estimate	NOUN
admet-757	124	26	,	,	PUNCT
admet-757	124	27	in	in	ADP
admet-757	124	28	this	this	DET
admet-757	124	29	case	case	NOUN
admet-757	124	30	7.2	7.2	NUM
admet-757	124	31	chi	chi	PROPN
admet-757	124	32	iam	iam	PROPN
admet-757	124	33	units	unit	NOUN
admet-757	124	34	.	.	PUNCT
admet-757	125	1	the	the	DET
admet-757	125	2	slope	slope	NOUN
admet-757	125	3	of	of	ADP
admet-757	125	4	the	the	DET
admet-757	125	5	regression	regression	NOUN
admet-757	125	6	line	line	NOUN
admet-757	125	7	(	(	PUNCT
admet-757	125	8	red	red	PROPN
admet-757	125	9	)	)	PUNCT
admet-757	125	10	is	be	AUX
admet-757	125	11	less	less	ADJ
admet-757	125	12	than	than	ADP
admet-757	125	13	one	one	NUM
admet-757	125	14	(	(	PUNCT
admet-757	125	15	0.81	0.81	NUM
admet-757	125	16	)	)	PUNCT
admet-757	125	17	and	and	CCONJ
admet-757	125	18	the	the	DET
admet-757	125	19	regression	regression	NOUN
admet-757	125	20	line	line	NOUN
admet-757	125	21	is	be	AUX
admet-757	125	22	different	different	ADJ
admet-757	125	23	from	from	ADP
admet-757	125	24	the	the	DET
admet-757	125	25	line	line	NOUN
admet-757	125	26	of	of	ADP
admet-757	125	27	unity	unity	NOUN
admet-757	125	28	(	(	PUNCT
admet-757	125	29	green	green	ADJ
admet-757	125	30	)	)	PUNCT
admet-757	125	31	.	.	PUNCT
admet-757	126	1	when	when	SCONJ
admet-757	126	2	these	these	DET
admet-757	126	3	4	4	NUM
admet-757	126	4	strong	strong	ADJ
admet-757	126	5	basic	basic	ADJ
admet-757	126	6	compounds	compound	NOUN
admet-757	126	7	are	be	AUX
admet-757	126	8	left	leave	VERB
admet-757	126	9	out	out	ADP
admet-757	126	10	from	from	ADP
admet-757	126	11	the	the	DET
admet-757	126	12	correlation	correlation	NOUN
admet-757	126	13	,	,	PUNCT
admet-757	126	14	the	the	DET
admet-757	126	15	correlation	correlation	NOUN
admet-757	126	16	coefficient	coefficient	NOUN
admet-757	126	17	increases	increase	VERB
admet-757	126	18	to	to	ADP
admet-757	126	19	0.96	0.96	NUM
admet-757	126	20	and	and	CCONJ
admet-757	126	21	the	the	DET
admet-757	126	22	slope	slope	NOUN
admet-757	126	23	increases	increase	VERB
admet-757	126	24	to	to	ADP
admet-757	126	25	0.82	0.82	NUM
admet-757	126	26	as	as	SCONJ
admet-757	126	27	shown	show	VERB
admet-757	126	28	in	in	ADP
admet-757	126	29	figure	figure	NOUN
admet-757	126	30	4	4	NUM
admet-757	126	31	.	.	PUNCT
admet-757	127	1	the	the	DET
admet-757	127	2	results	result	NOUN
admet-757	127	3	shown	show	VERB
admet-757	127	4	in	in	ADP
admet-757	127	5	figure	figure	NOUN
admet-757	127	6	4	4	NUM
admet-757	127	7	suggests	suggest	VERB
admet-757	127	8	that	that	SCONJ
admet-757	127	9	the	the	DET
admet-757	127	10	rank	rank	NOUN
admet-757	127	11	order	order	NOUN
admet-757	127	12	of	of	ADP
admet-757	127	13	the	the	DET
admet-757	127	14	phospholipid	phospholipid	NOUN
admet-757	127	15	binding	bind	VERB
admet-757	127	16	will	will	AUX
admet-757	127	17	be	be	AUX
admet-757	127	18	very	very	ADV
admet-757	127	19	similar	similar	ADJ
admet-757	127	20	using	use	VERB
admet-757	127	21	the	the	DET
admet-757	127	22	chi	chi	PROPN
admet-757	127	23	iam	iam	PROPN
admet-757	127	24	data	datum	NOUN
admet-757	127	25	obtained	obtain	VERB
admet-757	127	26	on	on	ADP
admet-757	127	27	the	the	DET
admet-757	127	28	new	new	ADJ
admet-757	127	29	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	127	30	column	column	NOUN
admet-757	127	31	and	and	CCONJ
admet-757	127	32	the	the	DET
admet-757	127	33	old	old	ADJ
admet-757	127	34	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	127	35	column	column	PROPN
admet-757	127	36	.	.	PUNCT
admet-757	128	1	however	however	ADV
admet-757	128	2	,	,	PUNCT
admet-757	128	3	some	some	DET
admet-757	128	4	basic	basic	ADJ
admet-757	128	5	compounds	compound	NOUN
admet-757	128	6	may	may	AUX
admet-757	128	7	show	show	VERB
admet-757	128	8	significantly	significantly	ADV
admet-757	128	9	weaker	weak	ADJ
admet-757	128	10	phospholipid	phospholipid	NOUN
admet-757	128	11	binding	bind	VERB
admet-757	128	12	.	.	PUNCT
admet-757	129	1	the	the	DET
admet-757	129	2	absolute	absolute	ADJ
admet-757	129	3	chi	chi	PROPN
admet-757	129	4	iam	iam	PROPN
admet-757	129	5	values	value	NOUN
admet-757	129	6	maybe	maybe	ADV
admet-757	129	7	lower	low	ADJ
admet-757	129	8	when	when	SCONJ
admet-757	129	9	the	the	DET
admet-757	129	10	new	new	ADJ
admet-757	129	11	batches	batch	NOUN
admet-757	129	12	of	of	ADP
admet-757	129	13	iam	iam	PROPN
admet-757	129	14	columns	column	NOUN
admet-757	129	15	are	be	AUX
admet-757	129	16	used	use	VERB
admet-757	129	17	.	.	PUNCT
admet-757	130	1	admet	admet	PROPN
admet-757	130	2	&	&	CCONJ
admet-757	130	3	dmpk	dmpk	PROPN
admet-757	130	4	8(1	8(1	NOUN
admet-757	130	5	)	)	PUNCT
admet-757	130	6	(	(	PUNCT
admet-757	130	7	2020	2020	NUM
admet-757	130	8	)	)	PUNCT
admet-757	130	9	78	78	NUM
admet-757	130	10	-	-	SYM
admet-757	130	11	97	97	NUM
admet-757	130	12	revisiting	revisit	VERB
admet-757	130	13	the	the	DET
admet-757	130	14	iam	iam	PROPN
admet-757	130	15	chromatography	chromatography	NOUN
admet-757	130	16	doi	doi	PROPN
admet-757	130	17	:	:	PUNCT
admet-757	130	18	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	130	19	87	87	NUM
admet-757	130	20	figure	figure	NOUN
admet-757	130	21	2	2	NUM
admet-757	130	22	.	.	PUNCT
admet-757	131	1	the	the	DET
admet-757	131	2	plot	plot	NOUN
admet-757	131	3	of	of	ADP
admet-757	131	4	the	the	DET
admet-757	131	5	experimental	experimental	ADJ
admet-757	131	6	chi	chi	NOUN
admet-757	131	7	(	(	PUNCT
admet-757	131	8	iam	iam	PROPN
admet-757	131	9	)	)	PUNCT
admet-757	131	10	values	value	NOUN
admet-757	131	11	on	on	ADP
admet-757	131	12	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	131	13	columns	column	NOUN
admet-757	131	14	p20511	p20511	NOUN
admet-757	131	15	-	-	PUNCT
admet-757	131	16	014	014	NUM
admet-757	131	17	-	-	PUNCT
admet-757	131	18	3	3	NUM
admet-757	131	19	and	and	CCONJ
admet-757	131	20	r20511	r20511	NUM
admet-757	131	21	-	-	PUNCT
admet-757	131	22	014	014	NUM
admet-757	131	23	-	-	PUNCT
admet-757	131	24	3	3	NUM
admet-757	131	25	figure	figure	NOUN
admet-757	131	26	3	3	NUM
admet-757	131	27	.	.	PUNCT
admet-757	132	1	the	the	DET
admet-757	132	2	plot	plot	NOUN
admet-757	132	3	of	of	ADP
admet-757	132	4	the	the	DET
admet-757	132	5	chi	chi	NOUN
admet-757	132	6	(	(	PUNCT
admet-757	132	7	iam	iam	PROPN
admet-757	132	8	)	)	PUNCT
admet-757	132	9	values	value	NOUN
admet-757	132	10	from	from	ADP
admet-757	132	11	the	the	DET
admet-757	132	12	literature	literature	NOUN
admet-757	132	13	[	[	X
admet-757	132	14	13	13	NUM
admet-757	132	15	]	]	PUNCT
admet-757	132	16	(	(	PUNCT
admet-757	132	17	reference	reference	NOUN
admet-757	132	18	chi	chi	NOUN
admet-757	132	19	(	(	PUNCT
admet-757	132	20	iam	iam	PROPN
admet-757	132	21	)	)	PUNCT
admet-757	132	22	)	)	PUNCT
admet-757	132	23	with	with	ADP
admet-757	132	24	the	the	DET
admet-757	132	25	chi	chi	NOUN
admet-757	132	26	(	(	PUNCT
admet-757	132	27	iam	iam	PROPN
admet-757	132	28	)	)	PUNCT
admet-757	132	29	values	value	NOUN
admet-757	132	30	using	use	VERB
admet-757	132	31	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	132	32	column	column	NOUN
admet-757	132	33	r25011	r25011	NOUN
admet-757	132	34	-	-	PUNCT
admet-757	132	35	014	014	NUM
admet-757	132	36	-	-	SYM
admet-757	132	37	3	3	NUM
admet-757	132	38	.	.	PUNCT
admet-757	133	1	the	the	DET
admet-757	133	2	green	green	ADJ
admet-757	133	3	line	line	NOUN
admet-757	133	4	is	be	AUX
admet-757	133	5	the	the	DET
admet-757	133	6	line	line	NOUN
admet-757	133	7	of	of	ADP
admet-757	133	8	unity	unity	NOUN
admet-757	133	9	.	.	PUNCT
admet-757	134	1	figure	figure	NOUN
admet-757	134	2	4	4	NUM
admet-757	134	3	.	.	NOUN
admet-757	134	4	comparison	comparison	NOUN
admet-757	134	5	of	of	ADP
admet-757	134	6	the	the	DET
admet-757	134	7	experimental	experimental	ADJ
admet-757	134	8	chi	chi	NOUN
admet-757	134	9	(	(	PUNCT
admet-757	134	10	iam	iam	PROPN
admet-757	134	11	)	)	PUNCT
admet-757	134	12	values	value	NOUN
admet-757	134	13	obtained	obtain	VERB
admet-757	134	14	on	on	ADP
admet-757	134	15	the	the	DET
admet-757	134	16	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	134	17	(	(	PUNCT
admet-757	134	18	r20511	r20511	NUM
admet-757	134	19	-	-	PUNCT
admet-757	134	20	014	014	NUM
admet-757	134	21	-	-	PUNCT
admet-757	134	22	3	3	NUM
admet-757	134	23	)	)	PUNCT
admet-757	134	24	column	column	NOUN
admet-757	134	25	with	with	ADP
admet-757	134	26	the	the	DET
admet-757	134	27	reference	reference	NOUN
admet-757	134	28	chi	chi	NOUN
admet-757	134	29	(	(	PUNCT
admet-757	134	30	iam	iam	PROPN
admet-757	134	31	)	)	PUNCT
admet-757	134	32	values	value	NOUN
admet-757	134	33	without	without	ADP
admet-757	134	34	the	the	DET
admet-757	134	35	4	4	NUM
admet-757	134	36	strong	strong	ADJ
admet-757	134	37	basic	basic	ADJ
admet-757	134	38	compounds	compound	NOUN
admet-757	134	39	.	.	PUNCT
admet-757	135	1	the	the	DET
admet-757	135	2	green	green	ADJ
admet-757	135	3	line	line	NOUN
admet-757	135	4	is	be	AUX
admet-757	135	5	the	the	DET
admet-757	135	6	line	line	NOUN
admet-757	135	7	of	of	ADP
admet-757	135	8	unity	unity	NOUN
admet-757	135	9	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	136	1	klara	klara	PROPN
admet-757	136	2	valko	valko	PROPN
admet-757	136	3	et	et	PROPN
admet-757	136	4	al	al	PROPN
admet-757	136	5	.	.	PROPN
admet-757	136	6	admet	admet	PROPN
admet-757	136	7	&	&	CCONJ
admet-757	136	8	dmpk	dmpk	PROPN
admet-757	136	9	8(1	8(1	NOUN
admet-757	136	10	)	)	PUNCT
admet-757	136	11	(	(	PUNCT
admet-757	136	12	2020	2020	NUM
admet-757	136	13	)	)	PUNCT
admet-757	136	14	78	78	NUM
admet-757	136	15	-	-	SYM
admet-757	136	16	97	97	NUM
admet-757	136	17	88	88	NUM
admet-757	136	18	the	the	DET
admet-757	136	19	human	human	ADJ
admet-757	136	20	clinical	clinical	ADJ
admet-757	136	21	volume	volume	NOUN
admet-757	136	22	of	of	ADP
admet-757	136	23	distribution	distribution	NOUN
admet-757	136	24	and	and	CCONJ
admet-757	136	25	protein	protein	NOUN
admet-757	136	26	binding	bind	VERB
admet-757	136	27	data	datum	NOUN
admet-757	136	28	of	of	ADP
admet-757	136	29	the	the	DET
admet-757	136	30	investigated	investigate	VERB
admet-757	136	31	marketed	market	VERB
admet-757	136	32	drugs	drug	NOUN
admet-757	136	33	the	the	DET
admet-757	136	34	volume	volume	NOUN
admet-757	136	35	of	of	ADP
admet-757	136	36	distribution	distribution	NOUN
admet-757	136	37	model	model	NOUN
admet-757	136	38	is	be	AUX
admet-757	136	39	based	base	VERB
admet-757	136	40	on	on	ADP
admet-757	136	41	two	two	NUM
admet-757	136	42	properties	property	NOUN
admet-757	136	43	of	of	ADP
admet-757	136	44	the	the	DET
admet-757	136	45	compounds	compound	NOUN
admet-757	136	46	,	,	PUNCT
admet-757	136	47	the	the	DET
admet-757	136	48	iam	iam	PROPN
admet-757	136	49	binding	bind	VERB
admet-757	136	50	and	and	CCONJ
admet-757	136	51	the	the	DET
admet-757	136	52	human	human	ADJ
admet-757	136	53	serum	serum	NOUN
admet-757	136	54	albumin	albumin	PROPN
admet-757	136	55	(	(	PUNCT
admet-757	136	56	hsa	hsa	PROPN
admet-757	136	57	)	)	PUNCT
admet-757	136	58	binding	binding	NOUN
admet-757	136	59	.	.	PUNCT
admet-757	137	1	therefore	therefore	ADV
admet-757	137	2	,	,	PUNCT
admet-757	137	3	the	the	DET
admet-757	137	4	iam	iam	PROPN
admet-757	137	5	binding	bind	VERB
admet-757	137	6	data	datum	NOUN
admet-757	137	7	obtained	obtain	VERB
admet-757	137	8	using	use	VERB
admet-757	137	9	the	the	DET
admet-757	137	10	new	new	ADJ
admet-757	137	11	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	137	12	columns	column	NOUN
admet-757	137	13	were	be	AUX
admet-757	137	14	examined	examine	VERB
admet-757	137	15	in	in	ADP
admet-757	137	16	the	the	DET
admet-757	137	17	models	model	NOUN
admet-757	137	18	of	of	ADP
admet-757	137	19	the	the	DET
admet-757	137	20	human	human	ADJ
admet-757	137	21	clinical	clinical	ADJ
admet-757	137	22	volume	volume	NOUN
admet-757	137	23	of	of	ADP
admet-757	137	24	distribution	distribution	NOUN
admet-757	137	25	together	together	ADV
admet-757	137	26	with	with	ADP
admet-757	137	27	the	the	DET
admet-757	137	28	re	re	ADJ
admet-757	137	29	-	-	ADJ
admet-757	137	30	measured	measure	VERB
admet-757	137	31	protein	protein	NOUN
admet-757	137	32	binding	bind	VERB
admet-757	137	33	data	datum	NOUN
admet-757	137	34	.	.	PUNCT
admet-757	138	1	figure	figure	NOUN
admet-757	138	2	5	5	NUM
admet-757	138	3	shows	show	VERB
admet-757	138	4	the	the	DET
admet-757	138	5	reproducibility	reproducibility	NOUN
admet-757	138	6	of	of	ADP
admet-757	138	7	the	the	DET
admet-757	138	8	hsa	hsa	PROPN
admet-757	138	9	columns	column	NOUN
admet-757	138	10	by	by	ADP
admet-757	138	11	plotting	plot	VERB
admet-757	138	12	the	the	DET
admet-757	138	13	newly	newly	ADV
admet-757	138	14	measured	measure	VERB
admet-757	138	15	log	log	NOUN
admet-757	138	16	k	k	PROPN
admet-757	138	17	(	(	PUNCT
admet-757	138	18	hsa	hsa	PROPN
admet-757	138	19	)	)	PUNCT
admet-757	138	20	values	value	NOUN
admet-757	138	21	as	as	ADP
admet-757	138	22	a	a	DET
admet-757	138	23	function	function	NOUN
admet-757	138	24	of	of	ADP
admet-757	138	25	the	the	DET
admet-757	138	26	“	"	PUNCT
admet-757	138	27	reference	reference	NOUN
admet-757	138	28	log	log	NOUN
admet-757	138	29	k	k	PROPN
admet-757	138	30	(	(	PUNCT
admet-757	138	31	hsa	hsa	PROPN
admet-757	138	32	)	)	PUNCT
admet-757	138	33	“	"	PUNCT
admet-757	138	34	values	value	NOUN
admet-757	138	35	published	publish	VERB
admet-757	138	36	previously	previously	ADV
admet-757	138	37	[	[	X
admet-757	138	38	13	13	NUM
admet-757	138	39	]	]	PUNCT
admet-757	138	40	.	.	PUNCT
admet-757	139	1	it	it	PRON
admet-757	139	2	can	can	AUX
admet-757	139	3	be	be	AUX
admet-757	139	4	seen	see	VERB
admet-757	139	5	that	that	SCONJ
admet-757	139	6	the	the	DET
admet-757	139	7	slope	slope	NOUN
admet-757	139	8	is	be	AUX
admet-757	139	9	very	very	ADV
admet-757	139	10	close	close	ADJ
admet-757	139	11	to	to	ADP
admet-757	139	12	1	1	NUM
admet-757	139	13	and	and	CCONJ
admet-757	139	14	the	the	DET
admet-757	139	15	intercept	intercept	NOUN
admet-757	139	16	is	be	AUX
admet-757	139	17	very	very	ADV
admet-757	139	18	close	close	ADJ
admet-757	139	19	to	to	ADP
admet-757	139	20	0	0	NUM
admet-757	139	21	.	.	PUNCT
admet-757	140	1	there	there	PRON
admet-757	140	2	are	be	VERB
admet-757	140	3	slightly	slightly	ADV
admet-757	140	4	greater	great	ADJ
admet-757	140	5	discrepancies	discrepancy	NOUN
admet-757	140	6	between	between	ADP
admet-757	140	7	the	the	DET
admet-757	140	8	reference	reference	NOUN
admet-757	140	9	and	and	CCONJ
admet-757	140	10	the	the	DET
admet-757	140	11	re	re	ADJ
admet-757	140	12	-	-	ADJ
admet-757	140	13	measured	measure	VERB
admet-757	140	14	log	log	NOUN
admet-757	140	15	k	k	PROPN
admet-757	140	16	(	(	PUNCT
admet-757	140	17	hsa	hsa	PROPN
admet-757	140	18	)	)	PUNCT
admet-757	140	19	values	value	NOUN
admet-757	140	20	for	for	ADP
admet-757	140	21	strongly	strongly	ADV
admet-757	140	22	bound	bind	VERB
admet-757	140	23	compounds	compound	NOUN
admet-757	140	24	.	.	PUNCT
admet-757	141	1	this	this	PRON
admet-757	141	2	shows	show	VERB
admet-757	141	3	that	that	SCONJ
admet-757	141	4	the	the	DET
admet-757	141	5	specific	specific	ADJ
admet-757	141	6	binding	bind	VERB
admet-757	141	7	sites	site	NOUN
admet-757	141	8	of	of	ADP
admet-757	141	9	the	the	DET
admet-757	141	10	human	human	ADJ
admet-757	141	11	serum	serum	NOUN
admet-757	141	12	albumin	albumin	NOUN
admet-757	141	13	may	may	AUX
admet-757	141	14	vary	vary	VERB
admet-757	141	15	only	only	ADV
admet-757	141	16	slightly	slightly	ADV
admet-757	141	17	from	from	ADP
admet-757	141	18	column	column	NOUN
admet-757	141	19	to	to	ADP
admet-757	141	20	column	column	PROPN
admet-757	141	21	.	.	PUNCT
admet-757	142	1	with	with	ADP
admet-757	142	2	this	this	DET
admet-757	142	3	excellent	excellent	ADJ
admet-757	142	4	agreement	agreement	NOUN
admet-757	142	5	between	between	ADP
admet-757	142	6	the	the	DET
admet-757	142	7	log	log	NOUN
admet-757	142	8	k	k	PROPN
admet-757	142	9	(	(	PUNCT
admet-757	142	10	hsa	hsa	PROPN
admet-757	142	11	)	)	PUNCT
admet-757	142	12	values	value	NOUN
admet-757	142	13	obtained	obtain	VERB
admet-757	142	14	on	on	ADP
admet-757	142	15	various	various	ADJ
admet-757	142	16	chiral	chiral	ADJ
admet-757	142	17	hsa	hsa	NOUN
admet-757	142	18	columns	column	NOUN
admet-757	142	19	,	,	PUNCT
admet-757	142	20	it	it	PRON
admet-757	142	21	can	can	AUX
admet-757	142	22	be	be	AUX
admet-757	142	23	assumed	assume	VERB
admet-757	142	24	that	that	SCONJ
admet-757	142	25	they	they	PRON
admet-757	142	26	would	would	AUX
admet-757	142	27	not	not	PART
admet-757	142	28	affect	affect	VERB
admet-757	142	29	the	the	DET
admet-757	142	30	volume	volume	NOUN
admet-757	142	31	of	of	ADP
admet-757	142	32	distribution	distribution	NOUN
admet-757	142	33	model	model	NOUN
admet-757	142	34	which	which	PRON
admet-757	142	35	is	be	AUX
admet-757	142	36	based	base	VERB
admet-757	142	37	on	on	ADP
admet-757	142	38	two	two	NUM
admet-757	142	39	binding	bind	VERB
admet-757	142	40	properties	property	NOUN
admet-757	142	41	for	for	ADP
admet-757	142	42	the	the	DET
admet-757	142	43	compounds	compound	NOUN
admet-757	142	44	,	,	PUNCT
admet-757	142	45	namely	namely	ADV
admet-757	142	46	the	the	DET
admet-757	142	47	iam	iam	PROPN
admet-757	142	48	and	and	CCONJ
admet-757	142	49	hsa	hsa	AUX
admet-757	142	50	binding	bind	VERB
admet-757	142	51	.	.	PUNCT
admet-757	143	1	figure	figure	NOUN
admet-757	143	2	5	5	NUM
admet-757	143	3	the	the	DET
admet-757	143	4	plot	plot	NOUN
admet-757	143	5	of	of	ADP
admet-757	143	6	the	the	DET
admet-757	143	7	log	log	NOUN
admet-757	143	8	k	k	PROPN
admet-757	143	9	(	(	PUNCT
admet-757	143	10	hsa	hsa	PROPN
admet-757	143	11	)	)	PUNCT
admet-757	143	12	values	value	NOUN
admet-757	143	13	from	from	ADP
admet-757	143	14	the	the	DET
admet-757	143	15	literature	literature	NOUN
admet-757	143	16	[	[	X
admet-757	143	17	13	13	NUM
admet-757	143	18	]	]	PUNCT
admet-757	143	19	and	and	CCONJ
admet-757	143	20	the	the	DET
admet-757	143	21	re	re	ADJ
admet-757	143	22	-	-	ADJ
admet-757	143	23	measured	measure	VERB
admet-757	143	24	log	log	NOUN
admet-757	143	25	k	k	PROPN
admet-757	143	26	(	(	PUNCT
admet-757	143	27	hsa	hsa	PROPN
admet-757	143	28	)	)	PUNCT
admet-757	143	29	for	for	ADP
admet-757	143	30	this	this	DET
admet-757	143	31	study	study	NOUN
admet-757	143	32	estimating	estimate	VERB
admet-757	143	33	the	the	DET
admet-757	143	34	volume	volume	NOUN
admet-757	143	35	of	of	ADP
admet-757	143	36	distribution	distribution	NOUN
admet-757	143	37	using	use	VERB
admet-757	143	38	the	the	DET
admet-757	143	39	old	old	ADJ
admet-757	143	40	and	and	CCONJ
admet-757	143	41	new	new	ADJ
admet-757	143	42	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	143	43	columns	column	VERB
admet-757	143	44	the	the	DET
admet-757	143	45	logarithmic	logarithmic	ADJ
admet-757	143	46	values	value	NOUN
admet-757	143	47	of	of	ADP
admet-757	143	48	the	the	DET
admet-757	143	49	hsa	hsa	PROPN
admet-757	143	50	and	and	CCONJ
admet-757	143	51	iam	iam	PROPN
admet-757	143	52	binding	bind	VERB
admet-757	143	53	data	datum	NOUN
admet-757	143	54	have	have	AUX
admet-757	143	55	been	be	AUX
admet-757	143	56	used	use	VERB
admet-757	143	57	to	to	PART
admet-757	143	58	estimate	estimate	VERB
admet-757	143	59	the	the	DET
admet-757	143	60	human	human	ADJ
admet-757	143	61	clinical	clinical	ADJ
admet-757	143	62	volume	volume	NOUN
admet-757	143	63	of	of	ADP
admet-757	143	64	distribution	distribution	NOUN
admet-757	143	65	.	.	PUNCT
admet-757	144	1	using	use	VERB
admet-757	144	2	the	the	DET
admet-757	144	3	published	publish	VERB
admet-757	144	4	equation	equation	NOUN
admet-757	144	5	(	(	PUNCT
admet-757	144	6	equation	equation	NOUN
admet-757	144	7	4	4	NUM
admet-757	144	8	)	)	PUNCT
admet-757	144	9	,	,	PUNCT
admet-757	144	10	the	the	DET
admet-757	144	11	estimated	estimate	VERB
admet-757	144	12	values	value	NOUN
admet-757	144	13	are	be	AUX
admet-757	144	14	compared	compare	VERB
admet-757	144	15	using	use	VERB
admet-757	144	16	the	the	DET
admet-757	144	17	iam	iam	PROPN
admet-757	144	18	data	datum	NOUN
admet-757	144	19	obtained	obtain	VERB
admet-757	144	20	on	on	ADP
admet-757	144	21	columns	column	NOUN
admet-757	144	22	r20511	r20511	NUM
admet-757	144	23	-	-	PUNCT
admet-757	144	24	014	014	NUM
admet-757	144	25	-	-	PUNCT
admet-757	144	26	3	3	NUM
admet-757	144	27	and	and	CCONJ
admet-757	144	28	p20511	p20511	NOUN
admet-757	144	29	-	-	PUNCT
admet-757	144	30	014	014	NUM
admet-757	144	31	-	-	SYM
admet-757	144	32	3	3	NUM
admet-757	144	33	and	and	CCONJ
admet-757	144	34	the	the	DET
admet-757	144	35	iam	iam	PROPN
admet-757	144	36	data	datum	NOUN
admet-757	144	37	from	from	ADP
admet-757	144	38	the	the	DET
admet-757	144	39	literature	literature	NOUN
admet-757	144	40	[	[	X
admet-757	144	41	12	12	NUM
admet-757	144	42	]	]	PUNCT
admet-757	144	43	.	.	PUNCT
admet-757	145	1	the	the	DET
admet-757	145	2	estimated	estimate	VERB
admet-757	145	3	log	log	NOUN
admet-757	145	4	vdss	vdss	ADJ
admet-757	145	5	values	value	NOUN
admet-757	145	6	have	have	AUX
admet-757	145	7	been	be	AUX
admet-757	145	8	calculated	calculate	VERB
admet-757	145	9	using	use	VERB
admet-757	145	10	equation	equation	NOUN
admet-757	145	11	4	4	NUM
admet-757	145	12	and	and	CCONJ
admet-757	145	13	the	the	DET
admet-757	145	14	measured	measure	VERB
admet-757	145	15	log	log	NOUN
admet-757	145	16	k	k	PROPN
admet-757	145	17	(	(	PUNCT
admet-757	145	18	hsa	hsa	PROPN
admet-757	145	19	)	)	PUNCT
admet-757	145	20	and	and	CCONJ
admet-757	145	21	log	log	VERB
admet-757	145	22	k	k	PROPN
admet-757	145	23	(	(	PUNCT
admet-757	145	24	hsa	hsa	PROPN
admet-757	145	25	)	)	PUNCT
admet-757	145	26	data	datum	NOUN
admet-757	145	27	obtained	obtain	VERB
admet-757	145	28	on	on	ADP
admet-757	145	29	the	the	DET
admet-757	145	30	new	new	ADJ
admet-757	145	31	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	145	32	columns	column	NOUN
admet-757	145	33	.	.	PUNCT
admet-757	146	1	the	the	DET
admet-757	146	2	estimated	estimate	VERB
admet-757	146	3	log	log	NOUN
admet-757	146	4	vdss	vdss	ADJ
admet-757	146	5	values	value	NOUN
admet-757	146	6	are	be	AUX
admet-757	146	7	listed	list	VERB
admet-757	146	8	in	in	ADP
admet-757	146	9	table	table	NOUN
admet-757	146	10	5	5	NUM
admet-757	146	11	together	together	ADV
admet-757	146	12	with	with	ADP
admet-757	146	13	the	the	DET
admet-757	146	14	acid	acid	NOUN
admet-757	146	15	/	/	SYM
admet-757	146	16	base	base	NOUN
admet-757	146	17	character	character	NOUN
admet-757	146	18	of	of	ADP
admet-757	146	19	the	the	DET
admet-757	146	20	compounds	compound	NOUN
admet-757	146	21	.	.	PUNCT
admet-757	147	1	figure	figure	NOUN
admet-757	147	2	6	6	NUM
admet-757	147	3	shows	show	VERB
admet-757	147	4	the	the	DET
admet-757	147	5	plot	plot	NOUN
admet-757	147	6	of	of	ADP
admet-757	147	7	the	the	DET
admet-757	147	8	estimated	estimate	VERB
admet-757	147	9	log	log	NOUN
admet-757	147	10	vdss	vdss	ADV
admet-757	147	11	values	value	NOUN
admet-757	147	12	using	use	VERB
admet-757	147	13	the	the	DET
admet-757	147	14	chi	chi	NOUN
admet-757	147	15	(	(	PUNCT
admet-757	147	16	iam	iam	PROPN
admet-757	147	17	)	)	PUNCT
admet-757	147	18	values	value	NOUN
admet-757	147	19	obtained	obtain	VERB
admet-757	147	20	on	on	ADP
admet-757	147	21	the	the	DET
admet-757	147	22	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	147	23	column	column	NOUN
admet-757	147	24	p20511	p20511	NOUN
admet-757	147	25	-	-	PUNCT
admet-757	147	26	014	014	NUM
admet-757	147	27	-	-	SYM
admet-757	147	28	3	3	NUM
admet-757	147	29	and	and	CCONJ
admet-757	147	30	those	those	PRON
admet-757	147	31	derived	derive	VERB
admet-757	147	32	from	from	ADP
admet-757	147	33	the	the	DET
admet-757	147	34	reference	reference	NOUN
admet-757	147	35	chi	chi	NOUN
admet-757	147	36	(	(	PUNCT
admet-757	147	37	iam	iam	PROPN
admet-757	147	38	)	)	PUNCT
admet-757	147	39	values	value	NOUN
admet-757	147	40	.	.	PUNCT
admet-757	148	1	a	a	DET
admet-757	148	2	good	good	ADJ
admet-757	148	3	correlation	correlation	NOUN
admet-757	148	4	was	be	AUX
admet-757	148	5	found	find	VERB
admet-757	148	6	between	between	ADP
admet-757	148	7	the	the	DET
admet-757	148	8	estimated	estimate	VERB
admet-757	148	9	log	log	NOUN
admet-757	148	10	vdss	vdss	ADJ
admet-757	148	11	values	value	NOUN
admet-757	148	12	.	.	PUNCT
admet-757	149	1	in	in	ADP
admet-757	149	2	this	this	DET
admet-757	149	3	study	study	NOUN
admet-757	149	4	equation	equation	NOUN
admet-757	149	5	4	4	NUM
admet-757	149	6	was	be	AUX
admet-757	149	7	used	use	VERB
admet-757	149	8	with	with	ADP
admet-757	149	9	the	the	DET
admet-757	149	10	same	same	ADJ
admet-757	149	11	log	log	NOUN
admet-757	149	12	k	k	PROPN
admet-757	149	13	(	(	PUNCT
admet-757	149	14	hsa	hsa	PROPN
admet-757	149	15	)	)	PUNCT
admet-757	149	16	values	value	NOUN
admet-757	149	17	and	and	CCONJ
admet-757	149	18	different	different	ADJ
admet-757	149	19	log	log	NOUN
admet-757	149	20	k	k	PROPN
admet-757	149	21	(	(	PUNCT
admet-757	149	22	iam	iam	PROPN
admet-757	149	23	)	)	PUNCT
admet-757	149	24	values	value	NOUN
admet-757	149	25	(	(	PUNCT
admet-757	149	26	depending	depend	VERB
admet-757	149	27	on	on	ADP
admet-757	149	28	which	which	PRON
admet-757	149	29	iam	iam	PROPN
admet-757	149	30	column	column	NOUN
admet-757	149	31	was	be	AUX
admet-757	149	32	used	use	VERB
admet-757	149	33	)	)	PUNCT
admet-757	149	34	.	.	PUNCT
admet-757	150	1	admet	admet	PROPN
admet-757	150	2	&	&	CCONJ
admet-757	150	3	dmpk	dmpk	PROPN
admet-757	150	4	8(1	8(1	NOUN
admet-757	150	5	)	)	PUNCT
admet-757	150	6	(	(	PUNCT
admet-757	150	7	2020	2020	NUM
admet-757	150	8	)	)	PUNCT
admet-757	150	9	78	78	NUM
admet-757	150	10	-	-	SYM
admet-757	150	11	97	97	NUM
admet-757	150	12	revisiting	revisit	VERB
admet-757	150	13	the	the	DET
admet-757	150	14	iam	iam	PROPN
admet-757	150	15	chromatography	chromatography	NOUN
admet-757	150	16	doi	doi	PROPN
admet-757	150	17	:	:	PUNCT
admet-757	150	18	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	150	19	89	89	NUM
admet-757	150	20	table	table	NOUN
admet-757	150	21	5	5	NUM
admet-757	150	22	.	.	PUNCT
admet-757	151	1	the	the	DET
admet-757	151	2	estimated	estimate	VERB
admet-757	151	3	log	log	NOUN
admet-757	151	4	vdss	vdss	ADJ
admet-757	151	5	values	value	NOUN
admet-757	151	6	of	of	ADP
admet-757	151	7	the	the	DET
admet-757	151	8	investigated	investigate	VERB
admet-757	151	9	compounds	compound	NOUN
admet-757	151	10	using	use	VERB
admet-757	151	11	equation	equation	NOUN
admet-757	151	12	4	4	NUM
admet-757	151	13	and	and	CCONJ
admet-757	151	14	their	their	PRON
admet-757	151	15	acid	acid	NOUN
admet-757	151	16	/	/	SYM
admet-757	151	17	base	base	NOUN
admet-757	151	18	character	character	NOUN
admet-757	151	19	drug	drug	NOUN
admet-757	151	20	name	name	NOUN
admet-757	151	21	acid	acid	NOUN
admet-757	151	22	/	/	SYM
admet-757	151	23	base	base	NOUN
admet-757	151	24	character	character	NOUN
admet-757	151	25	r20511	r20511	NUM
admet-757	151	26	-	-	PUNCT
admet-757	151	27	014	014	NUM
admet-757	151	28	-	-	SYM
admet-757	151	29	3	3	NUM
admet-757	151	30	log	log	VERB
admet-757	151	31	vdss	vdss	ADV
admet-757	151	32	p20511	p20511	NOUN
admet-757	151	33	-	-	PUNCT
admet-757	151	34	014	014	NUM
admet-757	151	35	-	-	SYM
admet-757	151	36	3	3	NUM
admet-757	151	37	log	log	NOUN
admet-757	151	38	vdss	vdss	ADJ
admet-757	151	39	reference	reference	NOUN
admet-757	151	40	log	log	VERB
admet-757	151	41	vdss	vdss	ADV
admet-757	151	42	acecainide	acecainide	ADV
admet-757	151	43	basic	basic	ADJ
admet-757	151	44	-0.03	-0.03	NUM
admet-757	151	45	-0.03	-0.03	NUM
admet-757	151	46	0.1	0.1	NUM
admet-757	151	47	acetanilide	acetanilide	ADV
admet-757	151	48	neutral	neutral	ADJ
admet-757	151	49	-0.12	-0.12	NUM
admet-757	151	50	-0.12	-0.12	NUM
admet-757	151	51	-0.13	-0.13	NUM
admet-757	151	52	acetazolamide	acetazolamide	ADV
admet-757	151	53	neutral	neutral	PROPN
admet-757	151	54	-0.47	-0.47	PROPN
admet-757	151	55	-0.47	-0.47	PRON
admet-757	151	56	-0.46	-0.46	NUM
admet-757	151	57	alclofenac	alclofenac	ADJ
admet-757	151	58	acidic	acidic	ADJ
admet-757	151	59	-1.04	-1.04	NOUN
admet-757	151	60	-1.02	-1.02	NUM
admet-757	151	61	-1.1	-1.1	PROPN
admet-757	151	62	amoxapine	amoxapine	X
admet-757	151	63	basic	basic	ADJ
admet-757	151	64	0.62	0.62	NUM
admet-757	151	65	0.57	0.57	NUM
admet-757	151	66	1.67	1.67	NUM
admet-757	151	67	bamethan	bamethan	NOUN
admet-757	151	68	basic	basic	ADJ
admet-757	151	69	0.01	0.01	NUM
admet-757	151	70	0	0	NUM
admet-757	151	71	0.01	0.01	NUM
admet-757	151	72	betamethasone	betamethasone	NOUN
admet-757	151	73	neutral	neutral	ADJ
admet-757	151	74	0.12	0.12	NUM
admet-757	151	75	0.12	0.12	NUM
admet-757	151	76	0.18	0.18	NUM
admet-757	151	77	carbamazepine	carbamazepine	NOUN
admet-757	151	78	neutral	neutral	ADJ
admet-757	151	79	-0.07	-0.07	NUM
admet-757	151	80	-0.07	-0.07	INTJ
admet-757	151	81	-0.09	-0.09	NUM
admet-757	151	82	chlorpromazine	chlorpromazine	NOUN
admet-757	151	83	basic	basic	ADJ
admet-757	151	84	0.88	0.88	NUM
admet-757	151	85	0.82	0.82	NUM
admet-757	151	86	2.15	2.15	NUM
admet-757	151	87	cinoxacin	cinoxacin	NOUN
admet-757	151	88	acidic	acidic	ADJ
admet-757	151	89	-0.38	-0.38	PUNCT
admet-757	151	90	-0.37	-0.37	NUM
admet-757	151	91	-0.42	-0.42	ADV
admet-757	151	92	colchicine	colchicine	PROPN
admet-757	151	93	neutral	neutral	ADJ
admet-757	151	94	0.02	0.02	NUM
admet-757	151	95	0.01	0.01	NUM
admet-757	151	96	0.03	0.03	NUM
admet-757	151	97	cytarabine	cytarabine	NOUN
admet-757	151	98	weak	weak	ADJ
admet-757	151	99	base	base	PROPN
admet-757	151	100	-0.26	-0.26	X
admet-757	151	101	-0.26	-0.26	X
admet-757	151	102	-0.31	-0.31	X
admet-757	151	103	diazoxide	diazoxide	NOUN
admet-757	151	104	weak	weak	ADJ
admet-757	151	105	acid	acid	NOUN
admet-757	151	106	-0.19	-0.19	NOUN
admet-757	151	107	-0.19	-0.19	NOUN
admet-757	151	108	-0.16	-0.16	PRON
admet-757	151	109	diclofenac	diclofenac	VERB
admet-757	151	110	acidic	acidic	ADJ
admet-757	151	111	-0.6	-0.6	X
admet-757	151	112	-0.57	-0.57	X
admet-757	151	113	-0.67	-0.67	PROPN
admet-757	151	114	diprophylline	diprophylline	PROPN
admet-757	151	115	neutral	neutral	ADJ
admet-757	152	1	-0.22	-0.22	NUM
admet-757	152	2	-0.23	-0.23	PROPN
admet-757	152	3	-0.24	-0.24	PROPN
admet-757	152	4	ethinyl	ethinyl	PROPN
admet-757	152	5	estradiol	estradiol	PROPN
admet-757	152	6	neutral	neutral	ADJ
admet-757	152	7	0.28	0.28	NUM
admet-757	152	8	0.27	0.27	NUM
admet-757	152	9	0.39	0.39	NUM
admet-757	152	10	famotidine	famotidine	NOUN
admet-757	152	11	weak	weak	ADJ
admet-757	152	12	base	base	NOUN
admet-757	152	13	-0.04	-0.04	PROPN
admet-757	152	14	-0.05	-0.05	NUM
admet-757	152	15	-0.06	-0.06	NUM
admet-757	152	16	felbamate	felbamate	NOUN
admet-757	152	17	neutral	neutral	ADJ
admet-757	152	18	0.07	0.07	NUM
admet-757	152	19	0.07	0.07	NUM
admet-757	152	20	-0.64	-0.64	NUM
admet-757	152	21	felodipine	felodipine	ADJ
admet-757	152	22	neutral	neutral	ADJ
admet-757	152	23	0.23	0.23	NUM
admet-757	152	24	0.23	0.23	NUM
admet-757	152	25	0.35	0.35	NUM
admet-757	152	26	fenoprofen	fenoprofen	ADJ
admet-757	152	27	acidic	acidic	ADJ
admet-757	152	28	-1.02	-1.02	NUM
admet-757	153	1	-0.98	-0.98	NUM
admet-757	153	2	-1.27	-1.27	NUM
admet-757	153	3	finasteride	finasteride	ADV
admet-757	153	4	neutral	neutral	ADJ
admet-757	153	5	0.21	0.21	NUM
admet-757	153	6	0.21	0.21	NUM
admet-757	153	7	0.3	0.3	NUM
admet-757	153	8	floxacillin	floxacillin	NOUN
admet-757	153	9	acidic	acidic	ADJ
admet-757	153	10	-0.55	-0.55	NUM
admet-757	153	11	-0.53	-0.53	NOUN
admet-757	153	12	-0.56	-0.56	NUM
admet-757	153	13	flumazenil	flumazenil	NOUN
admet-757	153	14	neutral	neutral	ADJ
admet-757	153	15	-0.04	-0.04	NUM
admet-757	153	16	-0.04	-0.04	NUM
admet-757	153	17	-0.04	-0.04	PROPN
admet-757	153	18	flurbiprofen	flurbiprofen	NOUN
admet-757	153	19	acidic	acidic	ADJ
admet-757	153	20	-1.44	-1.44	ADV
admet-757	153	21	-1.42	-1.42	NUM
admet-757	153	22	-1.56	-1.56	NUM
admet-757	153	23	furosemide	furosemide	ADJ
admet-757	153	24	acidic	acidic	ADJ
admet-757	153	25	-0.7	-0.7	PROPN
admet-757	153	26	-0.68	-0.68	NOUN
admet-757	153	27	-0.71	-0.71	PUNCT
admet-757	153	28	gemfibrozil	gemfibrozil	NOUN
admet-757	153	29	acidic	acidic	ADJ
admet-757	153	30	-1.31	-1.31	NUM
admet-757	153	31	-1.27	-1.27	NUM
admet-757	153	32	-1.34	-1.34	ADJ
admet-757	153	33	glipizide	glipizide	ADJ
admet-757	153	34	acidic	acidic	ADJ
admet-757	153	35	-0.69	-0.69	NOUN
admet-757	153	36	-0.68	-0.68	NOUN
admet-757	153	37	-0.73	-0.73	PUNCT
admet-757	153	38	griseofulvin	griseofulvin	NOUN
admet-757	153	39	neutral	neutral	ADJ
admet-757	153	40	0.04	0.04	NUM
admet-757	153	41	0.03	0.03	NUM
admet-757	153	42	0.12	0.12	NUM
admet-757	153	43	hydrochlorothiazide	hydrochlorothiazide	NOUN
admet-757	153	44	weak	weak	ADJ
admet-757	153	45	acid	acid	PROPN
admet-757	153	46	-0.18	-0.18	NUM
admet-757	153	47	-0.17	-0.17	PROPN
admet-757	153	48	-0.13	-0.13	NUM
admet-757	153	49	hydrocortisone	hydrocortisone	NOUN
admet-757	153	50	neutral	neutral	ADJ
admet-757	153	51	0.1	0.1	NUM
admet-757	153	52	0.09	0.09	NUM
admet-757	153	53	0.12	0.12	NUM
admet-757	153	54	imipramine	imipramine	ADJ
admet-757	153	55	basic	basic	ADJ
admet-757	153	56	0.66	0.66	NUM
admet-757	153	57	0.6	0.6	NUM
admet-757	153	58	1.16	1.16	NUM
admet-757	153	59	indomethacin	indomethacin	VERB
admet-757	153	60	acidic	acidic	ADJ
admet-757	153	61	-0.72	-0.72	PROPN
admet-757	153	62	-0.69	-0.69	NOUN
admet-757	153	63	-0.96	-0.96	NOUN
admet-757	153	64	isradipine	isradipine	NOUN
admet-757	153	65	neutral	neutral	ADJ
admet-757	153	66	0.08	0.08	NUM
admet-757	153	67	0.08	0.08	NUM
admet-757	153	68	0.13	0.13	NUM
admet-757	153	69	ketoconazole	ketoconazole	NOUN
admet-757	153	70	weak	weak	ADJ
admet-757	153	71	base	base	NOUN
admet-757	153	72	0.12	0.12	NUM
admet-757	153	73	0.1	0.1	NUM
admet-757	153	74	0.32	0.32	NUM
admet-757	153	75	ketoprofen	ketoprofen	NOUN
admet-757	153	76	acidic	acidic	ADJ
admet-757	153	77	-0.98	-0.98	PRON
admet-757	153	78	-0.96	-0.96	NUM
admet-757	153	79	-1.01	-1.01	ADJ
admet-757	153	80	labetalol	labetalol	NOUN
admet-757	153	81	amphoteric	amphoteric	ADJ
admet-757	153	82	0.38	0.38	NUM
admet-757	153	83	0.34	0.34	NUM
admet-757	153	84	0.71	0.71	NUM
admet-757	153	85	lignocaine	lignocaine	NOUN
admet-757	153	86	basic	basic	ADJ
admet-757	153	87	0.14	0.14	NUM
admet-757	153	88	0.16	0.16	NUM
admet-757	153	89	0.4	0.4	NUM
admet-757	153	90	methylprednisolone	methylprednisolone	NOUN
admet-757	153	91	neutral	neutral	ADJ
admet-757	153	92	0.12	0.12	NUM
admet-757	153	93	0.11	0.11	NUM
admet-757	153	94	0.16	0.16	NUM
admet-757	153	95	metronidazole	metronidazole	NOUN
admet-757	153	96	weak	weak	ADJ
admet-757	153	97	base	base	NOUN
admet-757	153	98	-0.24	-0.24	NUM
admet-757	153	99	-0.25	-0.25	NUM
admet-757	153	100	-0.25	-0.25	NUM
admet-757	153	101	minoxidil	minoxidil	ADJ
admet-757	153	102	weak	weak	ADJ
admet-757	153	103	base	base	NOUN
admet-757	153	104	-0.11	-0.11	X
admet-757	153	105	-0.1	-0.1	PROPN
admet-757	153	106	-0.04	-0.04	PROPN
admet-757	153	107	nabumetone	nabumetone	NOUN
admet-757	153	108	neutral	neutral	ADJ
admet-757	153	109	-0.09	-0.09	NUM
admet-757	153	110	-0.09	-0.09	NUM
admet-757	153	111	0.03	0.03	NUM
admet-757	153	112	nadolol	nadolol	X
admet-757	153	113	basic	basic	ADJ
admet-757	153	114	-0.34	-0.34	NOUN
admet-757	153	115	-0.35	-0.35	NUM
admet-757	153	116	-0.33	-0.33	PROPN
admet-757	153	117	nicardipine	nicardipine	NOUN
admet-757	153	118	weak	weak	ADJ
admet-757	153	119	base	base	NOUN
admet-757	153	120	0.32	0.32	NUM
admet-757	153	121	0.32	0.32	NUM
admet-757	153	122	0.47	0.47	NUM
admet-757	153	123	nifedipine	nifedipine	PROPN
admet-757	153	124	neutral	neutral	ADJ
admet-757	153	125	-0.07	-0.07	NUM
admet-757	153	126	-0.07	-0.07	NUM
admet-757	153	127	-0.04	-0.04	NUM
admet-757	153	128	nitrendipine	nitrendipine	ADJ
admet-757	153	129	neutral	neutral	ADJ
admet-757	153	130	0.08	0.08	NUM
admet-757	153	131	0.08	0.08	NUM
admet-757	153	132	0.16	0.16	NUM
admet-757	153	133	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	154	1	klara	klara	PROPN
admet-757	154	2	valko	valko	PROPN
admet-757	154	3	et	et	PROPN
admet-757	154	4	al	al	PROPN
admet-757	154	5	.	.	PROPN
admet-757	154	6	admet	admet	PROPN
admet-757	154	7	&	&	CCONJ
admet-757	154	8	dmpk	dmpk	PROPN
admet-757	154	9	8(1	8(1	NOUN
admet-757	154	10	)	)	PUNCT
admet-757	154	11	(	(	PUNCT
admet-757	154	12	2020	2020	NUM
admet-757	154	13	)	)	PUNCT
admet-757	154	14	78	78	NUM
admet-757	154	15	-	-	SYM
admet-757	154	16	97	97	NUM
admet-757	154	17	90	90	NUM
admet-757	154	18	papaverine	papaverine	NOUN
admet-757	154	19	weak	weak	ADJ
admet-757	154	20	base	base	NOUN
admet-757	155	1	-0.13	-0.13	PUNCT
admet-757	155	2	-0.13	-0.13	NUM
admet-757	155	3	0	0	NUM
admet-757	155	4	pentoxifylline	pentoxifylline	NOUN
admet-757	155	5	neutral	neutral	ADJ
admet-757	155	6	-0.07	-0.07	CCONJ
admet-757	155	7	-0.07	-0.07	INTJ
admet-757	155	8	-0.1	-0.1	PROPN
admet-757	155	9	perphenazine	perphenazine	ADJ
admet-757	155	10	basic	basic	ADJ
admet-757	155	11	0.66	0.66	NUM
admet-757	155	12	0.61	0.61	NUM
admet-757	155	13	1.35	1.35	NUM
admet-757	155	14	phenytoin	phenytoin	NOUN
admet-757	155	15	weak	weak	ADJ
admet-757	155	16	acid	acid	NOUN
admet-757	155	17	-0.02	-0.02	NUM
admet-757	155	18	-0.02	-0.02	NUM
admet-757	155	19	0.03	0.03	NUM
admet-757	155	20	pindolol	pindolol	NOUN
admet-757	155	21	basic	basic	ADJ
admet-757	155	22	0.14	0.14	NUM
admet-757	155	23	0.13	0.13	NUM
admet-757	155	24	0.85	0.85	NUM
admet-757	155	25	prazosin	prazosin	NOUN
admet-757	155	26	weak	weak	ADJ
admet-757	155	27	base	base	NOUN
admet-757	155	28	-0.11	-0.11	X
admet-757	155	29	-0.13	-0.13	NUM
admet-757	155	30	-0.05	-0.05	PRON
admet-757	155	31	prednisolone	prednisolone	PROPN
admet-757	155	32	neutral	neutral	ADJ
admet-757	155	33	0.12	0.12	NUM
admet-757	155	34	0.12	0.12	NUM
admet-757	155	35	0.14	0.14	NUM
admet-757	155	36	prednisone	prednisone	PROPN
admet-757	155	37	neutral	neutral	ADJ
admet-757	155	38	0.03	0.03	NUM
admet-757	155	39	0.03	0.03	NUM
admet-757	155	40	0.05	0.05	NUM
admet-757	155	41	primidone	primidone	NOUN
admet-757	155	42	neutral	neutral	ADJ
admet-757	155	43	-0.13	-0.13	NUM
admet-757	155	44	-0.13	-0.13	NUM
admet-757	155	45	-0.15	-0.15	NUM
admet-757	155	46	probenecid	probenecid	PROPN
admet-757	155	47	acidic	acidic	PROPN
admet-757	155	48	-0.66	-0.66	NUM
admet-757	155	49	-0.64	-0.64	NUM
admet-757	155	50	-0.75	-0.75	NUM
admet-757	155	51	procainamide	procainamide	NOUN
admet-757	155	52	basic	basic	ADJ
admet-757	155	53	-0.13	-0.13	NUM
admet-757	155	54	-0.12	-0.12	NUM
admet-757	155	55	0.02	0.02	NUM
admet-757	155	56	propanolol	propanolol	NOUN
admet-757	155	57	basic	basic	ADJ
admet-757	155	58	0.64	0.64	NUM
admet-757	155	59	0.59	0.59	NUM
admet-757	155	60	1.29	1.29	NUM
admet-757	155	61	propylthiouracil	propylthiouracil	ADJ
admet-757	155	62	weak	weak	ADJ
admet-757	155	63	acid	acid	NOUN
admet-757	155	64	-0.31	-0.31	NUM
admet-757	155	65	-0.31	-0.31	NUM
admet-757	155	66	-0.34	-0.34	NOUN
admet-757	155	67	proxyphylline	proxyphylline	NOUN
admet-757	155	68	neutral	neutral	ADJ
admet-757	155	69	-0.75	-0.75	NUM
admet-757	155	70	-0.74	-0.74	PROPN
admet-757	155	71	-0.85	-0.85	PROPN
admet-757	155	72	sulfachlorpyridazine	sulfachlorpyridazine	PROPN
admet-757	155	73	acidic	acidic	ADJ
admet-757	155	74	-0.71	-0.71	NOUN
admet-757	155	75	-0.7	-0.7	PROPN
admet-757	155	76	-0.76	-0.76	PROPN
admet-757	155	77	sulfameter	sulfameter	PROPN
admet-757	155	78	acidic	acidic	PROPN
admet-757	155	79	-0.57	-0.57	X
admet-757	155	80	-0.57	-0.57	X
admet-757	155	81	-0.61	-0.61	NOUN
admet-757	155	82	sulfamethoxypyridazine	sulfamethoxypyridazine	NOUN
admet-757	155	83	weak	weak	ADJ
admet-757	155	84	acid	acid	PROPN
admet-757	155	85	-0.57	-0.57	X
admet-757	155	86	-0.56	-0.56	NUM
admet-757	155	87	-0.59	-0.59	NUM
admet-757	155	88	sulfinpyrazone	sulfinpyrazone	NOUN
admet-757	155	89	acidic	acidic	ADJ
admet-757	155	90	-0.64	-0.64	PRON
admet-757	155	91	-0.62	-0.62	ADJ
admet-757	155	92	-0.65	-0.65	ADP
admet-757	155	93	sulfisoxazole	sulfisoxazole	ADJ
admet-757	155	94	acidic	acidic	ADJ
admet-757	155	95	-0.68	-0.68	PROPN
admet-757	155	96	-0.67	-0.67	PROPN
admet-757	155	97	-0.72	-0.72	PROPN
admet-757	155	98	sulphadimidine	sulphadimidine	PROPN
admet-757	155	99	amphoteric	amphoteric	ADJ
admet-757	156	1	-0.41	-0.41	ADP
admet-757	156	2	-0.41	-0.41	NUM
admet-757	156	3	0.22	0.22	NUM
admet-757	156	4	sulpiride	sulpiride	ADJ
admet-757	156	5	basic	basic	ADJ
admet-757	156	6	-0.11	-0.11	NUM
admet-757	156	7	-0.1	-0.1	PROPN
admet-757	156	8	0.12	0.12	NUM
admet-757	156	9	tamoxifen	tamoxifen	NOUN
admet-757	156	10	basic	basic	ADJ
admet-757	156	11	0.94	0.94	NUM
admet-757	156	12	0.89	0.89	NUM
admet-757	156	13	1.48	1.48	NUM
admet-757	156	14	theobromine	theobromine	ADJ
admet-757	156	15	weak	weak	ADJ
admet-757	156	16	acid	acid	NOUN
admet-757	156	17	-0.24	-0.24	NUM
admet-757	156	18	-0.25	-0.25	NUM
admet-757	156	19	-0.25	-0.25	NUM
admet-757	156	20	tolfenamic	tolfenamic	ADJ
admet-757	156	21	acid	acid	NOUN
admet-757	156	22	acidic	acidic	ADJ
admet-757	156	23	-0.54	-0.54	PROPN
admet-757	156	24	-0.49	-0.49	NOUN
admet-757	156	25	-0.76	-0.76	PROPN
admet-757	156	26	trazodone	trazodone	PROPN
admet-757	156	27	weak	weak	ADJ
admet-757	156	28	base	base	NOUN
admet-757	156	29	-0.09	-0.09	NUM
admet-757	156	30	-0.1	-0.1	NOUN
admet-757	156	31	0.01	0.01	NUM
admet-757	156	32	trimethoprim	trimethoprim	ADJ
admet-757	156	33	weak	weak	ADJ
admet-757	156	34	base	base	NOUN
admet-757	156	35	-0.05	-0.05	NUM
admet-757	156	36	-0.06	-0.06	PROPN
admet-757	156	37	-0.06	-0.06	PROPN
admet-757	156	38	warfarin	warfarin	NOUN
admet-757	156	39	acidic	acidic	ADJ
admet-757	156	40	-0.69	-0.69	NOUN
admet-757	156	41	-0.68	-0.68	NOUN
admet-757	156	42	-0.78	-0.78	NUM
admet-757	156	43	figure	figure	NOUN
admet-757	156	44	6	6	NUM
admet-757	156	45	.	.	PUNCT
admet-757	157	1	the	the	DET
admet-757	157	2	plot	plot	NOUN
admet-757	157	3	of	of	ADP
admet-757	157	4	the	the	DET
admet-757	157	5	estimated	estimate	VERB
admet-757	157	6	log	log	NOUN
admet-757	157	7	vdss	vdss	ADV
admet-757	157	8	values	value	NOUN
admet-757	157	9	using	use	VERB
admet-757	157	10	the	the	DET
admet-757	157	11	chi	chi	NOUN
admet-757	157	12	(	(	PUNCT
admet-757	157	13	iam	iam	PROPN
admet-757	157	14	)	)	PUNCT
admet-757	157	15	values	value	NOUN
admet-757	157	16	obtained	obtain	VERB
admet-757	157	17	on	on	ADP
admet-757	157	18	the	the	DET
admet-757	157	19	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	157	20	column	column	NOUN
admet-757	157	21	p20511	p20511	NOUN
admet-757	157	22	-	-	PUNCT
admet-757	157	23	014	014	NUM
admet-757	157	24	-	-	SYM
admet-757	157	25	3	3	NUM
admet-757	157	26	and	and	CCONJ
admet-757	157	27	from	from	ADP
admet-757	157	28	the	the	DET
admet-757	157	29	reference	reference	NOUN
admet-757	157	30	[	[	X
admet-757	157	31	13	13	NUM
admet-757	157	32	]	]	PUNCT
admet-757	157	33	.	.	PUNCT
admet-757	158	1	the	the	DET
admet-757	158	2	green	green	ADJ
admet-757	158	3	line	line	NOUN
admet-757	158	4	is	be	AUX
admet-757	158	5	the	the	DET
admet-757	158	6	line	line	NOUN
admet-757	158	7	of	of	ADP
admet-757	158	8	unity	unity	NOUN
admet-757	158	9	.	.	PUNCT
admet-757	159	1	figure	figure	NOUN
admet-757	159	2	7	7	NUM
admet-757	159	3	shows	show	VERB
admet-757	159	4	the	the	DET
admet-757	159	5	plot	plot	NOUN
admet-757	159	6	of	of	ADP
admet-757	159	7	the	the	DET
admet-757	159	8	estimated	estimate	VERB
admet-757	159	9	log	log	NOUN
admet-757	159	10	vdss	vdss	ADV
admet-757	159	11	values	value	NOUN
admet-757	159	12	using	use	VERB
admet-757	159	13	the	the	DET
admet-757	159	14	chi	chi	NOUN
admet-757	159	15	(	(	PUNCT
admet-757	159	16	iam	iam	PROPN
admet-757	159	17	)	)	PUNCT
admet-757	159	18	values	value	NOUN
admet-757	159	19	obtained	obtain	VERB
admet-757	159	20	on	on	ADP
admet-757	159	21	the	the	DET
admet-757	159	22	iam.pd.dd2	iam.pd.dd2	PROPN
admet-757	159	23	column	column	NOUN
admet-757	159	24	p20511	p20511	NOUN
admet-757	159	25	-	-	PUNCT
admet-757	159	26	014	014	NUM
admet-757	159	27	-	-	SYM
admet-757	159	28	3	3	NUM
admet-757	159	29	and	and	CCONJ
admet-757	159	30	those	those	PRON
admet-757	159	31	obtained	obtain	VERB
admet-757	159	32	from	from	ADP
admet-757	159	33	the	the	DET
admet-757	159	34	reference	reference	NOUN
admet-757	159	35	but	but	CCONJ
admet-757	159	36	without	without	ADP
admet-757	159	37	the	the	DET
admet-757	159	38	4	4	NUM
admet-757	159	39	strong	strong	ADJ
admet-757	159	40	basic	basic	ADJ
admet-757	159	41	compounds	compound	NOUN
admet-757	159	42	(	(	PUNCT
admet-757	159	43	procainamide	procainamide	ADJ
admet-757	159	44	,	,	PUNCT
admet-757	159	45	sulpiride	sulpiride	ADV
admet-757	159	46	,	,	PUNCT
admet-757	159	47	zolmitriptan	zolmitriptan	PROPN
admet-757	159	48	and	and	CCONJ
admet-757	159	49	pindolol	pindolol	NOUN
admet-757	159	50	)	)	PUNCT
admet-757	159	51	.	.	PUNCT
admet-757	160	1	it	it	PRON
admet-757	160	2	can	can	AUX
admet-757	160	3	be	be	AUX
admet-757	160	4	seen	see	VERB
admet-757	160	5	that	that	SCONJ
admet-757	160	6	the	the	DET
admet-757	160	7	agreement	agreement	NOUN
admet-757	160	8	is	be	AUX
admet-757	160	9	slightly	slightly	ADV
admet-757	160	10	improved	improve	VERB
admet-757	160	11	with	with	ADP
admet-757	160	12	an	an	DET
admet-757	160	13	r2	r2	NOUN
admet-757	160	14	value	value	NOUN
admet-757	160	15	of	of	ADP
admet-757	160	16	0.96	0.96	NUM
admet-757	160	17	,	,	PUNCT
admet-757	160	18	however	however	ADV
admet-757	160	19	,	,	PUNCT
admet-757	160	20	the	the	DET
admet-757	160	21	slope	slope	NOUN
admet-757	160	22	is	be	AUX
admet-757	160	23	still	still	ADV
admet-757	160	24	less	less	ADJ
admet-757	160	25	than	than	ADP
admet-757	160	26	one	one	NUM
admet-757	160	27	,	,	PUNCT
admet-757	160	28	while	while	SCONJ
admet-757	160	29	the	the	DET
admet-757	160	30	intercept	intercept	NOUN
admet-757	160	31	is	be	AUX
admet-757	160	32	admet	admet	PROPN
admet-757	160	33	&	&	CCONJ
admet-757	160	34	dmpk	dmpk	PROPN
admet-757	160	35	8(1	8(1	NOUN
admet-757	160	36	)	)	PUNCT
admet-757	160	37	(	(	PUNCT
admet-757	160	38	2020	2020	NUM
admet-757	160	39	)	)	PUNCT
admet-757	160	40	78	78	NUM
admet-757	160	41	-	-	SYM
admet-757	160	42	97	97	NUM
admet-757	160	43	revisiting	revisit	VERB
admet-757	160	44	the	the	DET
admet-757	160	45	iam	iam	PROPN
admet-757	160	46	chromatography	chromatography	NOUN
admet-757	160	47	doi	doi	PROPN
admet-757	160	48	:	:	PUNCT
admet-757	160	49	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	160	50	91	91	NUM
admet-757	160	51	close	close	ADV
admet-757	160	52	to	to	ADP
admet-757	160	53	zero	zero	NUM
admet-757	160	54	.	.	PUNCT
admet-757	161	1	this	this	PRON
admet-757	161	2	means	mean	VERB
admet-757	161	3	that	that	SCONJ
admet-757	161	4	the	the	DET
admet-757	161	5	rank	rank	NOUN
admet-757	161	6	order	order	NOUN
admet-757	161	7	of	of	ADP
admet-757	161	8	the	the	DET
admet-757	161	9	volume	volume	NOUN
admet-757	161	10	of	of	ADP
admet-757	161	11	distribution	distribution	NOUN
admet-757	161	12	data	datum	NOUN
admet-757	161	13	would	would	AUX
admet-757	161	14	be	be	AUX
admet-757	161	15	the	the	DET
admet-757	161	16	same	same	ADJ
admet-757	161	17	when	when	SCONJ
admet-757	161	18	using	use	VERB
admet-757	161	19	the	the	DET
admet-757	161	20	new	new	ADJ
admet-757	161	21	batches	batch	NOUN
admet-757	161	22	of	of	ADP
admet-757	161	23	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	161	24	columns	column	NOUN
admet-757	161	25	as	as	SCONJ
admet-757	161	26	it	it	PRON
admet-757	161	27	was	be	AUX
admet-757	161	28	when	when	SCONJ
admet-757	161	29	using	use	VERB
admet-757	161	30	the	the	DET
admet-757	161	31	old	old	ADJ
admet-757	161	32	batches	batch	NOUN
admet-757	161	33	of	of	ADP
admet-757	161	34	iam	iam	PROPN
admet-757	161	35	columns	column	NOUN
admet-757	161	36	.	.	PUNCT
admet-757	162	1	however	however	ADV
admet-757	162	2	,	,	PUNCT
admet-757	162	3	absolute	absolute	ADJ
admet-757	162	4	values	value	NOUN
admet-757	162	5	may	may	AUX
admet-757	162	6	be	be	AUX
admet-757	162	7	slightly	slightly	ADV
admet-757	162	8	different	different	ADJ
admet-757	162	9	for	for	ADP
admet-757	162	10	the	the	DET
admet-757	162	11	neutral	neutral	ADJ
admet-757	162	12	,	,	PUNCT
admet-757	162	13	acidic	acidic	ADJ
admet-757	162	14	and	and	CCONJ
admet-757	162	15	basic	basic	ADJ
admet-757	162	16	compounds	compound	NOUN
admet-757	162	17	and	and	CCONJ
admet-757	162	18	greater	great	ADJ
admet-757	162	19	discrepancies	discrepancy	NOUN
admet-757	162	20	can	can	AUX
admet-757	162	21	be	be	AUX
admet-757	162	22	expected	expect	VERB
admet-757	162	23	for	for	ADP
admet-757	162	24	some	some	DET
admet-757	162	25	strong	strong	ADJ
admet-757	162	26	basic	basic	ADJ
admet-757	162	27	compounds	compound	NOUN
admet-757	162	28	which	which	PRON
admet-757	162	29	are	be	AUX
admet-757	162	30	similar	similar	ADJ
admet-757	162	31	to	to	ADP
admet-757	162	32	those	those	PRON
admet-757	162	33	left	leave	VERB
admet-757	162	34	out	out	ADP
admet-757	162	35	from	from	ADP
admet-757	162	36	the	the	DET
admet-757	162	37	plot	plot	NOUN
admet-757	162	38	.	.	PUNCT
admet-757	163	1	figure	figure	NOUN
admet-757	163	2	7	7	NUM
admet-757	163	3	.	.	PUNCT
admet-757	164	1	the	the	DET
admet-757	164	2	plot	plot	NOUN
admet-757	164	3	of	of	ADP
admet-757	164	4	the	the	DET
admet-757	164	5	estimated	estimate	VERB
admet-757	164	6	log	log	NOUN
admet-757	164	7	vdss	vdss	ADV
admet-757	164	8	values	value	NOUN
admet-757	164	9	using	use	VERB
admet-757	164	10	the	the	DET
admet-757	164	11	chi	chi	NOUN
admet-757	164	12	(	(	PUNCT
admet-757	164	13	iam	iam	PROPN
admet-757	164	14	)	)	PUNCT
admet-757	164	15	values	value	NOUN
admet-757	164	16	obtained	obtain	VERB
admet-757	164	17	on	on	ADP
admet-757	164	18	column	column	NOUN
admet-757	164	19	p20511	p20511	PROPN
admet-757	164	20	-	-	PUNCT
admet-757	164	21	0143	0143	NUM
admet-757	164	22	and	and	CCONJ
admet-757	164	23	from	from	ADP
admet-757	164	24	the	the	DET
admet-757	164	25	reference	reference	NOUN
admet-757	164	26	values	value	NOUN
admet-757	164	27	[	[	X
admet-757	164	28	12	12	NUM
admet-757	164	29	]	]	PUNCT
admet-757	164	30	without	without	ADP
admet-757	164	31	the	the	DET
admet-757	164	32	four	four	NUM
admet-757	164	33	strong	strong	ADJ
admet-757	164	34	basic	basic	ADJ
admet-757	164	35	compounds	compound	NOUN
admet-757	164	36	.	.	PUNCT
admet-757	165	1	the	the	DET
admet-757	165	2	green	green	ADJ
admet-757	165	3	line	line	NOUN
admet-757	165	4	is	be	AUX
admet-757	165	5	the	the	DET
admet-757	165	6	line	line	NOUN
admet-757	165	7	of	of	ADP
admet-757	165	8	unity	unity	NOUN
admet-757	165	9	.	.	PUNCT
admet-757	166	1	it	it	PRON
admet-757	166	2	was	be	AUX
admet-757	166	3	important	important	ADJ
admet-757	166	4	to	to	PART
admet-757	166	5	investigate	investigate	VERB
admet-757	166	6	how	how	SCONJ
admet-757	166	7	the	the	DET
admet-757	166	8	estimated	estimate	VERB
admet-757	166	9	volume	volume	NOUN
admet-757	166	10	of	of	ADP
admet-757	166	11	distribution	distribution	NOUN
admet-757	166	12	using	use	VERB
admet-757	166	13	the	the	DET
admet-757	166	14	chi	chi	NOUN
admet-757	166	15	(	(	PUNCT
admet-757	166	16	iam	iam	PROPN
admet-757	166	17	)	)	PUNCT
admet-757	166	18	data	datum	NOUN
admet-757	166	19	from	from	ADP
admet-757	166	20	the	the	DET
admet-757	166	21	new	new	ADJ
admet-757	166	22	batches	batch	NOUN
admet-757	166	23	of	of	ADP
admet-757	166	24	the	the	DET
admet-757	166	25	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	166	26	columns	column	NOUN
admet-757	166	27	correlated	correlate	VERB
admet-757	166	28	with	with	ADP
admet-757	166	29	the	the	DET
admet-757	166	30	actual	actual	ADJ
admet-757	166	31	clinical	clinical	ADJ
admet-757	166	32	volume	volume	NOUN
admet-757	166	33	of	of	ADP
admet-757	166	34	distribution	distribution	NOUN
admet-757	166	35	data	datum	NOUN
admet-757	166	36	.	.	PUNCT
admet-757	167	1	figures	figure	NOUN
admet-757	167	2	8	8	NUM
admet-757	167	3	and	and	CCONJ
admet-757	167	4	9	9	NUM
admet-757	167	5	show	show	VERB
admet-757	167	6	the	the	DET
admet-757	167	7	correlation	correlation	NOUN
admet-757	167	8	of	of	ADP
admet-757	167	9	the	the	DET
admet-757	167	10	estimated	estimate	VERB
admet-757	167	11	log	log	NOUN
admet-757	167	12	vdss	vdss	ADV
admet-757	167	13	values	value	NOUN
admet-757	167	14	using	use	VERB
admet-757	167	15	the	the	DET
admet-757	167	16	same	same	ADJ
admet-757	167	17	coefficients	coefficient	NOUN
admet-757	167	18	as	as	ADP
admet-757	167	19	in	in	ADP
admet-757	167	20	equation	equation	NOUN
admet-757	167	21	4	4	NUM
admet-757	167	22	with	with	ADP
admet-757	167	23	the	the	DET
admet-757	167	24	clinical	clinical	ADJ
admet-757	167	25	log	log	NOUN
admet-757	167	26	vdss	vdss	ADJ
admet-757	167	27	values	value	NOUN
admet-757	167	28	.	.	PUNCT
admet-757	168	1	figure	figure	NOUN
admet-757	168	2	9	9	NUM
admet-757	168	3	shows	show	VERB
admet-757	168	4	that	that	SCONJ
admet-757	168	5	the	the	DET
admet-757	168	6	chi	chi	NOUN
admet-757	168	7	(	(	PUNCT
admet-757	168	8	iam	iam	PROPN
admet-757	168	9	)	)	PUNCT
admet-757	168	10	values	value	NOUN
admet-757	168	11	obtained	obtain	VERB
admet-757	168	12	on	on	ADP
admet-757	168	13	the	the	DET
admet-757	168	14	new	new	ADJ
admet-757	168	15	batches	batch	NOUN
admet-757	168	16	of	of	ADP
admet-757	168	17	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	168	18	column	column	NOUN
admet-757	168	19	can	can	AUX
admet-757	168	20	be	be	AUX
admet-757	168	21	used	use	VERB
admet-757	168	22	to	to	PART
admet-757	168	23	estimate	estimate	VERB
admet-757	168	24	the	the	DET
admet-757	168	25	human	human	ADJ
admet-757	168	26	clinical	clinical	ADJ
admet-757	168	27	volume	volume	NOUN
admet-757	168	28	of	of	ADP
admet-757	168	29	distribution	distribution	NOUN
admet-757	168	30	data	datum	NOUN
admet-757	168	31	by	by	ADP
admet-757	168	32	using	use	VERB
admet-757	168	33	equation	equation	NOUN
admet-757	168	34	4	4	NUM
admet-757	168	35	.	.	PUNCT
admet-757	169	1	there	there	PRON
admet-757	169	2	is	be	VERB
admet-757	169	3	better	well	ADJ
admet-757	169	4	agreement	agreement	NOUN
admet-757	169	5	with	with	ADP
admet-757	169	6	the	the	DET
admet-757	169	7	clinical	clinical	ADJ
admet-757	169	8	data	datum	NOUN
admet-757	169	9	when	when	SCONJ
admet-757	169	10	using	use	VERB
admet-757	169	11	the	the	DET
admet-757	169	12	log	log	NOUN
admet-757	169	13	vdss	vdss	ADV
admet-757	169	14	obtained	obtain	VERB
admet-757	169	15	on	on	ADP
admet-757	169	16	the	the	DET
admet-757	169	17	new	new	ADJ
admet-757	169	18	batch	batch	NOUN
admet-757	169	19	of	of	ADP
admet-757	169	20	the	the	DET
admet-757	169	21	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	169	22	column	column	PROPN
admet-757	169	23	.	.	PUNCT
admet-757	170	1	however	however	ADV
admet-757	170	2	,	,	PUNCT
admet-757	170	3	the	the	DET
admet-757	170	4	absolute	absolute	ADJ
admet-757	170	5	values	value	NOUN
admet-757	170	6	may	may	AUX
admet-757	170	7	be	be	AUX
admet-757	170	8	slightly	slightly	ADV
admet-757	170	9	different	different	ADJ
admet-757	170	10	and	and	CCONJ
admet-757	170	11	a	a	DET
admet-757	170	12	correction	correction	NOUN
admet-757	170	13	factor	factor	NOUN
admet-757	170	14	(	(	PUNCT
admet-757	170	15	slope	slope	NOUN
admet-757	170	16	0.62	0.62	NUM
admet-757	170	17	)	)	PUNCT
admet-757	170	18	will	will	AUX
admet-757	170	19	be	be	AUX
admet-757	170	20	required	require	VERB
admet-757	170	21	.	.	PUNCT
admet-757	171	1	in	in	ADP
admet-757	171	2	a	a	DET
admet-757	171	3	drug	drug	NOUN
admet-757	171	4	discovery	discovery	NOUN
admet-757	171	5	setting	set	VERB
admet-757	171	6	for	for	ADP
admet-757	171	7	ranking	rank	VERB
admet-757	171	8	and	and	CCONJ
admet-757	171	9	differentiating	differentiate	VERB
admet-757	171	10	compounds	compound	NOUN
admet-757	171	11	using	use	VERB
admet-757	171	12	an	an	DET
admet-757	171	13	estimated	estimate	VERB
admet-757	171	14	log	log	NOUN
admet-757	171	15	vdss	vdss	ADV
admet-757	171	16	,	,	PUNCT
admet-757	171	17	these	these	DET
admet-757	171	18	values	value	NOUN
admet-757	171	19	can	can	AUX
admet-757	171	20	be	be	AUX
admet-757	171	21	used	use	VERB
admet-757	171	22	with	with	ADP
admet-757	171	23	confidence	confidence	NOUN
admet-757	171	24	.	.	PUNCT
admet-757	172	1	however	however	ADV
admet-757	172	2	,	,	PUNCT
admet-757	172	3	it	it	PRON
admet-757	172	4	is	be	AUX
admet-757	172	5	important	important	ADJ
admet-757	172	6	to	to	PART
admet-757	172	7	acknowledge	acknowledge	VERB
admet-757	172	8	that	that	SCONJ
admet-757	172	9	certain	certain	ADJ
admet-757	172	10	strong	strong	ADJ
admet-757	172	11	basic	basic	ADJ
admet-757	172	12	compounds	compound	NOUN
admet-757	172	13	may	may	AUX
admet-757	172	14	appear	appear	VERB
admet-757	172	15	to	to	PART
admet-757	172	16	have	have	VERB
admet-757	172	17	a	a	DET
admet-757	172	18	lower	low	ADJ
admet-757	172	19	volume	volume	NOUN
admet-757	172	20	of	of	ADP
admet-757	172	21	distribution	distribution	NOUN
admet-757	172	22	than	than	SCONJ
admet-757	172	23	expected	expect	VERB
admet-757	172	24	.	.	PUNCT
admet-757	173	1	it	it	PRON
admet-757	173	2	was	be	AUX
admet-757	173	3	also	also	ADV
admet-757	173	4	important	important	ADJ
admet-757	173	5	to	to	PART
admet-757	173	6	investigate	investigate	VERB
admet-757	173	7	how	how	SCONJ
admet-757	173	8	the	the	DET
admet-757	173	9	chi	chi	NOUN
admet-757	173	10	(	(	PUNCT
admet-757	173	11	iam	iam	PROPN
admet-757	173	12	)	)	PUNCT
admet-757	173	13	and	and	CCONJ
admet-757	173	14	log	log	VERB
admet-757	173	15	k	k	PROPN
admet-757	173	16	(	(	PUNCT
admet-757	173	17	iam	iam	PROPN
admet-757	173	18	)	)	PUNCT
admet-757	173	19	values	value	NOUN
admet-757	173	20	perform	perform	VERB
admet-757	173	21	in	in	ADP
admet-757	173	22	other	other	ADJ
admet-757	173	23	in	in	ADP
admet-757	173	24	vivo	vivo	ADJ
admet-757	173	25	distribution	distribution	NOUN
admet-757	173	26	models	model	NOUN
admet-757	173	27	.	.	PUNCT
admet-757	174	1	estimating	estimate	VERB
admet-757	174	2	brain	brain	NOUN
admet-757	174	3	tissue	tissue	NOUN
admet-757	174	4	binding	bind	VERB
admet-757	174	5	using	use	VERB
admet-757	174	6	the	the	DET
admet-757	174	7	old	old	ADJ
admet-757	174	8	and	and	CCONJ
admet-757	174	9	new	new	ADJ
admet-757	174	10	batches	batch	NOUN
admet-757	174	11	of	of	ADP
admet-757	174	12	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	174	13	columns	column	VERB
admet-757	174	14	the	the	DET
admet-757	174	15	brain	brain	NOUN
admet-757	174	16	tissue	tissue	NOUN
admet-757	174	17	binding	bind	VERB
admet-757	174	18	can	can	AUX
admet-757	174	19	be	be	AUX
admet-757	174	20	estimated	estimate	VERB
admet-757	174	21	from	from	ADP
admet-757	174	22	the	the	DET
admet-757	174	23	sum	sum	NOUN
admet-757	174	24	of	of	ADP
admet-757	174	25	the	the	DET
admet-757	174	26	albumin	albumin	NOUN
admet-757	174	27	and	and	CCONJ
admet-757	174	28	the	the	DET
admet-757	174	29	phospholipid	phospholipid	NOUN
admet-757	174	30	binding	bind	VERB
admet-757	174	31	as	as	SCONJ
admet-757	174	32	described	describe	VERB
admet-757	174	33	by	by	ADP
admet-757	174	34	equation	equation	NOUN
admet-757	174	35	8	8	NUM
admet-757	174	36	.	.	PUNCT
admet-757	175	1	the	the	DET
admet-757	175	2	model	model	NOUN
admet-757	175	3	was	be	AUX
admet-757	175	4	built	build	VERB
admet-757	175	5	on	on	ADP
admet-757	175	6	135	135	NUM
admet-757	175	7	drug	drug	NOUN
admet-757	175	8	discovery	discovery	NOUN
admet-757	175	9	compounds	compound	NOUN
admet-757	175	10	from	from	ADP
admet-757	175	11	several	several	ADJ
admet-757	175	12	neuroscience	neuroscience	NOUN
admet-757	175	13	projects	project	NOUN
admet-757	175	14	using	use	VERB
admet-757	175	15	rat	rat	NOUN
admet-757	175	16	brain	brain	NOUN
admet-757	175	17	tissue	tissue	NOUN
admet-757	175	18	binding	bind	VERB
admet-757	175	19	data	datum	NOUN
admet-757	175	20	obtained	obtain	VERB
admet-757	175	21	by	by	ADP
admet-757	175	22	equilibrium	equilibrium	NOUN
admet-757	175	23	dialysis	dialysis	NOUN
admet-757	175	24	and	and	CCONJ
admet-757	175	25	measured	measure	VERB
admet-757	175	26	hsa	hsa	PROPN
admet-757	175	27	and	and	CCONJ
admet-757	175	28	iam	iam	PROPN
admet-757	175	29	binding	bind	VERB
admet-757	175	30	data	datum	NOUN
admet-757	175	31	as	as	SCONJ
admet-757	175	32	described	describe	VERB
admet-757	175	33	in	in	ADP
admet-757	175	34	reference	reference	NOUN
admet-757	175	35	[	[	X
admet-757	175	36	12	12	NUM
admet-757	175	37	]	]	PUNCT
admet-757	175	38	.	.	PUNCT
admet-757	176	1	log	log	PROPN
admet-757	176	2	k	k	PROPN
admet-757	177	1	(	(	PUNCT
admet-757	177	2	btb)=1.29	btb)=1.29	PROPN
admet-757	177	3	(	(	PUNCT
admet-757	177	4	±0.10	±0.10	PROPN
admet-757	177	5	)	)	PUNCT
admet-757	177	6	log	log	NOUN
admet-757	177	7	k	k	PROPN
admet-757	177	8	(	(	PUNCT
admet-757	177	9	iam	iam	PROPN
admet-757	177	10	)	)	PUNCT
admet-757	177	11	+	+	CCONJ
admet-757	177	12	1.03(±0.10	1.03(±0.10	NUM
admet-757	177	13	)	)	PUNCT
admet-757	177	14	log	log	NOUN
admet-757	177	15	k	k	PROPN
admet-757	177	16	(	(	PUNCT
admet-757	177	17	hsa	hsa	PROPN
admet-757	177	18	)	)	PUNCT
admet-757	177	19	0.237	0.237	NUM
admet-757	177	20	(	(	PUNCT
admet-757	177	21	8)	8)	NUM
admet-757	177	22	n=135	n=135	PRON
admet-757	177	23	r2=0.76	r2=0.76	PRON
admet-757	177	24	s=0.35	s=0.35	ADJ
admet-757	177	25	f=212	f=212	NUM
admet-757	177	26	where	where	SCONJ
admet-757	177	27	n	n	X
admet-757	177	28	is	be	AUX
admet-757	177	29	the	the	DET
admet-757	177	30	number	number	NOUN
admet-757	177	31	of	of	ADP
admet-757	177	32	compounds	compound	NOUN
admet-757	177	33	,	,	PUNCT
admet-757	177	34	r2	r2	PROPN
admet-757	177	35	is	be	AUX
admet-757	177	36	the	the	DET
admet-757	177	37	correlation	correlation	NOUN
admet-757	177	38	coefficient	coefficient	NOUN
admet-757	177	39	,	,	PUNCT
admet-757	177	40	s	s	X
admet-757	177	41	is	be	AUX
admet-757	177	42	the	the	DET
admet-757	177	43	standard	standard	ADJ
admet-757	177	44	error	error	NOUN
admet-757	177	45	of	of	ADP
admet-757	177	46	the	the	DET
admet-757	177	47	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	NOUN
admet-757	177	48	klara	klara	PROPN
admet-757	177	49	valko	valko	PROPN
admet-757	177	50	et	et	PROPN
admet-757	177	51	al	al	PROPN
admet-757	177	52	.	.	PROPN
admet-757	177	53	admet	admet	PROPN
admet-757	177	54	&	&	CCONJ
admet-757	177	55	dmpk	dmpk	PROPN
admet-757	177	56	8(1	8(1	NOUN
admet-757	177	57	)	)	PUNCT
admet-757	177	58	(	(	PUNCT
admet-757	177	59	2020	2020	NUM
admet-757	177	60	)	)	PUNCT
admet-757	177	61	78	78	NUM
admet-757	177	62	-	-	SYM
admet-757	177	63	97	97	NUM
admet-757	177	64	92	92	NUM
admet-757	177	65	estimate	estimate	NOUN
admet-757	177	66	and	and	CCONJ
admet-757	177	67	f	f	PROPN
admet-757	177	68	is	be	AUX
admet-757	177	69	the	the	DET
admet-757	177	70	fisher	fisher	NOUN
admet-757	177	71	-	-	PUNCT
admet-757	177	72	test	test	NOUN
admet-757	177	73	value	value	NOUN
admet-757	177	74	.	.	PUNCT
admet-757	178	1	figure	figure	NOUN
admet-757	178	2	8	8	NUM
admet-757	178	3	.	.	PUNCT
admet-757	179	1	the	the	DET
admet-757	179	2	plot	plot	NOUN
admet-757	179	3	of	of	ADP
admet-757	179	4	the	the	DET
admet-757	179	5	estimated	estimate	VERB
admet-757	179	6	and	and	CCONJ
admet-757	179	7	the	the	DET
admet-757	179	8	measured	measure	VERB
admet-757	179	9	clinical	clinical	ADJ
admet-757	179	10	volume	volume	NOUN
admet-757	179	11	of	of	ADP
admet-757	179	12	distribution	distribution	NOUN
admet-757	179	13	data	datum	NOUN
admet-757	179	14	using	use	VERB
admet-757	179	15	the	the	DET
admet-757	179	16	old	old	ADJ
admet-757	179	17	batches	batch	NOUN
admet-757	179	18	of	of	ADP
admet-757	179	19	iam	iam	PROPN
admet-757	179	20	columns	column	NOUN
admet-757	179	21	(	(	PUNCT
admet-757	179	22	reference	reference	NOUN
admet-757	179	23	[	[	X
admet-757	179	24	13	13	NUM
admet-757	179	25	]	]	PUNCT
admet-757	179	26	reference	reference	NOUN
admet-757	179	27	log	log	AUX
admet-757	179	28	vdss	vdss	ADV
admet-757	179	29	)	)	PUNCT
admet-757	179	30	using	use	VERB
admet-757	179	31	equation	equation	NOUN
admet-757	179	32	4	4	NUM
admet-757	179	33	.	.	PUNCT
admet-757	179	34	figure	figure	VERB
admet-757	179	35	9	9	NUM
admet-757	179	36	.	.	PUNCT
admet-757	180	1	the	the	DET
admet-757	180	2	plot	plot	NOUN
admet-757	180	3	of	of	ADP
admet-757	180	4	the	the	DET
admet-757	180	5	estimated	estimate	VERB
admet-757	180	6	and	and	CCONJ
admet-757	180	7	measured	measure	VERB
admet-757	180	8	clinical	clinical	ADJ
admet-757	180	9	volumes	volume	NOUN
admet-757	180	10	of	of	ADP
admet-757	180	11	distribution	distribution	NOUN
admet-757	180	12	using	use	VERB
admet-757	180	13	the	the	DET
admet-757	180	14	new	new	ADJ
admet-757	180	15	batch	batch	NOUN
admet-757	180	16	r20511	r20511	NUM
admet-757	180	17	-	-	PUNCT
admet-757	180	18	014	014	NUM
admet-757	180	19	-	-	SYM
admet-757	180	20	3	3	NUM
admet-757	180	21	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	180	22	column	column	NOUN
admet-757	180	23	versus	versus	ADP
admet-757	180	24	the	the	DET
admet-757	180	25	reference	reference	NOUN
admet-757	180	26	log	log	VERB
admet-757	180	27	vdss	vdss	ADV
admet-757	181	1	[	[	X
admet-757	181	2	13	13	NUM
admet-757	181	3	]	]	PUNCT
admet-757	181	4	.	.	PUNCT
admet-757	182	1	figure	figure	NOUN
admet-757	182	2	10	10	NUM
admet-757	182	3	shows	show	VERB
admet-757	182	4	the	the	DET
admet-757	182	5	comparison	comparison	NOUN
admet-757	182	6	of	of	ADP
admet-757	182	7	the	the	DET
admet-757	182	8	estimated	estimate	VERB
admet-757	182	9	brain	brain	NOUN
admet-757	182	10	tissue	tissue	NOUN
admet-757	182	11	binding	bind	VERB
admet-757	182	12	(	(	PUNCT
admet-757	182	13	%	%	INTJ
admet-757	182	14	btb	btb	NOUN
admet-757	182	15	)	)	PUNCT
admet-757	182	16	when	when	SCONJ
admet-757	182	17	the	the	DET
admet-757	182	18	old	old	ADJ
admet-757	182	19	(	(	PUNCT
admet-757	182	20	reference	reference	NOUN
admet-757	182	21	[	[	X
admet-757	182	22	13	13	NUM
admet-757	182	23	]	]	PUNCT
admet-757	182	24	)	)	PUNCT
admet-757	182	25	and	and	CCONJ
admet-757	182	26	the	the	DET
admet-757	182	27	new	new	ADJ
admet-757	182	28	column	column	NOUN
admet-757	182	29	p20511	p20511	NOUN
admet-757	182	30	-	-	PUNCT
admet-757	182	31	014	014	NUM
admet-757	182	32	-	-	SYM
admet-757	182	33	3	3	NUM
admet-757	182	34	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	182	35	data	datum	NOUN
admet-757	182	36	was	be	AUX
admet-757	182	37	used	use	VERB
admet-757	182	38	in	in	ADP
admet-757	182	39	the	the	DET
admet-757	182	40	model	model	NOUN
admet-757	182	41	.	.	PUNCT
admet-757	183	1	the	the	DET
admet-757	183	2	agreement	agreement	NOUN
admet-757	183	3	is	be	AUX
admet-757	183	4	very	very	ADV
admet-757	183	5	good	good	ADJ
admet-757	183	6	with	with	ADP
admet-757	183	7	an	an	DET
admet-757	183	8	r2	r2	NOUN
admet-757	183	9	value	value	NOUN
admet-757	183	10	of	of	ADP
admet-757	183	11	0.95	0.95	NUM
admet-757	183	12	,	,	PUNCT
admet-757	183	13	the	the	DET
admet-757	183	14	slope	slope	NOUN
admet-757	183	15	is	be	AUX
admet-757	183	16	close	close	ADJ
admet-757	183	17	to	to	ADP
admet-757	183	18	1	1	NUM
admet-757	183	19	and	and	CCONJ
admet-757	183	20	the	the	DET
admet-757	183	21	intercept	intercept	NOUN
admet-757	183	22	is	be	AUX
admet-757	183	23	close	close	ADJ
admet-757	183	24	to	to	ADP
admet-757	183	25	zero	zero	NUM
admet-757	183	26	using	use	VERB
admet-757	183	27	the	the	DET
admet-757	183	28	chi	chi	NOUN
admet-757	183	29	(	(	PUNCT
admet-757	183	30	iam	iam	PROPN
admet-757	183	31	)	)	PUNCT
admet-757	183	32	values	value	NOUN
admet-757	183	33	obtained	obtain	VERB
admet-757	183	34	on	on	ADP
admet-757	183	35	p20511	p20511	NOUN
admet-757	183	36	-	-	PUNCT
admet-757	183	37	014	014	NUM
admet-757	183	38	-	-	SYM
admet-757	183	39	3	3	NUM
admet-757	183	40	from	from	ADP
admet-757	183	41	the	the	DET
admet-757	183	42	latest	late	ADJ
admet-757	183	43	batch	batch	NOUN
admet-757	183	44	of	of	ADP
admet-757	183	45	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	183	46	columns	column	NOUN
admet-757	183	47	.	.	PUNCT
admet-757	184	1	however	however	ADV
admet-757	184	2	,	,	PUNCT
admet-757	184	3	the	the	DET
admet-757	184	4	four	four	NUM
admet-757	184	5	basic	basic	ADJ
admet-757	184	6	compounds	compound	NOUN
admet-757	184	7	that	that	PRON
admet-757	184	8	showed	show	VERB
admet-757	184	9	significantly	significantly	ADV
admet-757	184	10	lower	low	ADJ
admet-757	184	11	chi	chi	NOUN
admet-757	184	12	(	(	PUNCT
admet-757	184	13	iam	iam	PROPN
admet-757	184	14	)	)	PUNCT
admet-757	184	15	values	value	NOUN
admet-757	184	16	are	be	AUX
admet-757	184	17	significant	significant	ADJ
admet-757	184	18	outliers	outlier	NOUN
admet-757	184	19	resulting	result	VERB
admet-757	184	20	in	in	ADP
admet-757	184	21	these	these	DET
admet-757	184	22	compounds	compound	NOUN
admet-757	184	23	being	be	AUX
admet-757	184	24	estimated	estimate	VERB
admet-757	184	25	to	to	PART
admet-757	184	26	have	have	VERB
admet-757	184	27	lower	low	ADJ
admet-757	184	28	brain	brain	NOUN
admet-757	184	29	tissue	tissue	NOUN
admet-757	184	30	binding	bind	VERB
admet-757	184	31	than	than	ADP
admet-757	184	32	their	their	PRON
admet-757	184	33	actual	actual	ADJ
admet-757	184	34	brain	brain	NOUN
admet-757	184	35	tissue	tissue	NOUN
admet-757	184	36	binding	bind	VERB
admet-757	184	37	.	.	PUNCT
admet-757	185	1	estimating	estimate	VERB
admet-757	185	2	the	the	DET
admet-757	185	3	unbound	unbound	NOUN
admet-757	185	4	volume	volume	NOUN
admet-757	185	5	of	of	ADP
admet-757	185	6	distribution	distribution	NOUN
admet-757	185	7	using	use	VERB
admet-757	185	8	the	the	DET
admet-757	185	9	old	old	ADJ
admet-757	185	10	and	and	CCONJ
admet-757	185	11	new	new	ADJ
admet-757	185	12	batches	batch	NOUN
admet-757	185	13	of	of	ADP
admet-757	185	14	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	185	15	columns	column	VERB
admet-757	185	16	the	the	DET
admet-757	185	17	agreement	agreement	NOUN
admet-757	185	18	between	between	ADP
admet-757	185	19	the	the	DET
admet-757	185	20	estimated	estimate	VERB
admet-757	185	21	unbound	unbound	NOUN
admet-757	185	22	volume	volume	NOUN
admet-757	185	23	of	of	ADP
admet-757	185	24	distribution	distribution	NOUN
admet-757	185	25	data	datum	NOUN
admet-757	185	26	using	use	VERB
admet-757	185	27	the	the	DET
admet-757	185	28	reference	reference	NOUN
admet-757	185	29	[	[	X
admet-757	185	30	13	13	NUM
admet-757	185	31	]	]	X
admet-757	185	32	chi	chi	NOUN
admet-757	185	33	(	(	PUNCT
admet-757	185	34	iam	iam	PROPN
admet-757	185	35	)	)	PUNCT
admet-757	185	36	values	value	NOUN
admet-757	185	37	and	and	CCONJ
admet-757	185	38	the	the	DET
admet-757	185	39	chi	chi	PROPN
admet-757	185	40	iam	iam	PROPN
admet-757	185	41	values	value	NOUN
admet-757	185	42	obtained	obtain	VERB
admet-757	185	43	on	on	ADP
admet-757	185	44	column	column	NOUN
admet-757	185	45	r25011	r25011	PROPN
admet-757	185	46	-	-	PUNCT
admet-757	185	47	014	014	NUM
admet-757	185	48	-	-	SYM
admet-757	185	49	3	3	NUM
admet-757	185	50	are	be	AUX
admet-757	185	51	shown	show	VERB
admet-757	185	52	in	in	ADP
admet-757	185	53	figure	figure	NOUN
admet-757	185	54	11	11	NUM
admet-757	185	55	.	.	PUNCT
admet-757	186	1	admet	admet	PROPN
admet-757	186	2	&	&	CCONJ
admet-757	186	3	dmpk	dmpk	PROPN
admet-757	186	4	8(1	8(1	NOUN
admet-757	186	5	)	)	PUNCT
admet-757	186	6	(	(	PUNCT
admet-757	186	7	2020	2020	NUM
admet-757	186	8	)	)	PUNCT
admet-757	186	9	78	78	NUM
admet-757	186	10	-	-	SYM
admet-757	186	11	97	97	NUM
admet-757	186	12	revisiting	revisit	VERB
admet-757	186	13	the	the	DET
admet-757	186	14	iam	iam	PROPN
admet-757	186	15	chromatography	chromatography	NOUN
admet-757	186	16	doi	doi	PROPN
admet-757	186	17	:	:	PUNCT
admet-757	186	18	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	186	19	93	93	NUM
admet-757	186	20	figure	figure	NOUN
admet-757	186	21	10	10	NUM
admet-757	186	22	.	.	PUNCT
admet-757	187	1	the	the	DET
admet-757	187	2	plot	plot	NOUN
admet-757	187	3	of	of	ADP
admet-757	187	4	the	the	DET
admet-757	187	5	estimated	estimate	VERB
admet-757	187	6	brain	brain	NOUN
admet-757	187	7	tissue	tissue	NOUN
admet-757	187	8	binding	bind	VERB
admet-757	187	9	(	(	PUNCT
admet-757	187	10	%	%	INTJ
admet-757	187	11	btb	btb	NOUN
admet-757	187	12	)	)	PUNCT
admet-757	187	13	obtained	obtain	VERB
admet-757	187	14	using	use	VERB
admet-757	187	15	the	the	DET
admet-757	187	16	iam	iam	PROPN
admet-757	187	17	data	datum	NOUN
admet-757	187	18	obtained	obtain	VERB
admet-757	187	19	from	from	ADP
admet-757	187	20	the	the	DET
admet-757	187	21	reference	reference	NOUN
admet-757	187	22	[	[	X
admet-757	187	23	13	13	NUM
admet-757	187	24	]	]	PUNCT
admet-757	187	25	and	and	CCONJ
admet-757	187	26	that	that	PRON
admet-757	187	27	obtained	obtain	VERB
admet-757	187	28	using	use	VERB
admet-757	187	29	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	187	30	column	column	NOUN
admet-757	187	31	p20511	p20511	NOUN
admet-757	187	32	-	-	PUNCT
admet-757	187	33	014	014	NUM
admet-757	187	34	-	-	PUNCT
admet-757	187	35	3	3	NUM
admet-757	187	36	figure	figure	NOUN
admet-757	187	37	11	11	NUM
admet-757	187	38	.	.	PUNCT
admet-757	188	1	a	a	DET
admet-757	188	2	plot	plot	NOUN
admet-757	188	3	of	of	ADP
admet-757	188	4	the	the	DET
admet-757	188	5	estimated	estimate	VERB
admet-757	188	6	unbound	unbound	NOUN
admet-757	188	7	volume	volume	NOUN
admet-757	188	8	of	of	ADP
admet-757	188	9	distribution	distribution	NOUN
admet-757	188	10	using	use	VERB
admet-757	188	11	the	the	DET
admet-757	188	12	iam	iam	PROPN
admet-757	188	13	data	datum	NOUN
admet-757	188	14	from	from	ADP
admet-757	188	15	the	the	DET
admet-757	188	16	reference	reference	NOUN
admet-757	188	17	(	(	PUNCT
admet-757	188	18	reference	reference	NOUN
admet-757	188	19	[	[	X
admet-757	188	20	12	12	NUM
admet-757	188	21	]	]	PUNCT
admet-757	188	22	)	)	PUNCT
admet-757	188	23	and	and	CCONJ
admet-757	188	24	on	on	ADP
admet-757	188	25	the	the	DET
admet-757	188	26	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	188	27	r20511	r20511	PROPN
admet-757	188	28	-	-	PUNCT
admet-757	188	29	014	014	NUM
admet-757	188	30	-	-	SYM
admet-757	188	31	3	3	NUM
admet-757	188	32	column	column	NOUN
admet-757	188	33	it	it	PRON
admet-757	188	34	can	can	AUX
admet-757	188	35	be	be	AUX
admet-757	188	36	seen	see	VERB
admet-757	188	37	that	that	SCONJ
admet-757	188	38	the	the	DET
admet-757	188	39	estimated	estimate	VERB
admet-757	188	40	unbound	unbound	NOUN
admet-757	188	41	volume	volume	NOUN
admet-757	188	42	of	of	ADP
admet-757	188	43	distribution	distribution	NOUN
admet-757	188	44	using	use	VERB
admet-757	188	45	the	the	DET
admet-757	188	46	chi	chi	NOUN
admet-757	188	47	(	(	PUNCT
admet-757	188	48	iam	iam	PROPN
admet-757	188	49	)	)	PUNCT
admet-757	188	50	values	value	NOUN
admet-757	188	51	obtained	obtain	VERB
admet-757	188	52	on	on	ADP
admet-757	188	53	column	column	NOUN
admet-757	188	54	r20511	r20511	PROPN
admet-757	188	55	-	-	PUNCT
admet-757	188	56	014	014	NUM
admet-757	188	57	-	-	SYM
admet-757	188	58	3	3	NUM
admet-757	188	59	shows	show	VERB
admet-757	188	60	good	good	ADJ
admet-757	188	61	agreement	agreement	NOUN
admet-757	188	62	with	with	ADP
admet-757	188	63	the	the	DET
admet-757	188	64	logvdu	logvdu	NOUN
admet-757	188	65	from	from	ADP
admet-757	188	66	the	the	DET
admet-757	188	67	reference	reference	NOUN
admet-757	188	68	chi	chi	NOUN
admet-757	188	69	(	(	PUNCT
admet-757	188	70	iam	iam	PROPN
admet-757	188	71	)	)	PUNCT
admet-757	188	72	values	value	NOUN
admet-757	188	73	.	.	PUNCT
admet-757	189	1	it	it	PRON
admet-757	189	2	can	can	AUX
admet-757	189	3	be	be	AUX
admet-757	189	4	observed	observe	VERB
admet-757	189	5	from	from	ADP
admet-757	189	6	the	the	DET
admet-757	189	7	plot	plot	NOUN
admet-757	189	8	that	that	SCONJ
admet-757	189	9	basic	basic	ADJ
admet-757	189	10	compounds	compound	NOUN
admet-757	189	11	tend	tend	VERB
admet-757	189	12	to	to	PART
admet-757	189	13	show	show	VERB
admet-757	189	14	a	a	DET
admet-757	189	15	lower	low	ADJ
admet-757	189	16	unbound	unbound	NOUN
admet-757	189	17	volume	volume	NOUN
admet-757	189	18	of	of	ADP
admet-757	189	19	distribution	distribution	NOUN
admet-757	189	20	using	use	VERB
admet-757	189	21	the	the	DET
admet-757	189	22	chi	chi	NOUN
admet-757	189	23	(	(	PUNCT
admet-757	189	24	iam	iam	PROPN
admet-757	189	25	)	)	PUNCT
admet-757	189	26	values	value	NOUN
admet-757	189	27	obtained	obtain	VERB
admet-757	189	28	on	on	ADP
admet-757	189	29	the	the	DET
admet-757	189	30	new	new	ADJ
admet-757	189	31	column	column	NOUN
admet-757	189	32	r20511	r20511	NUM
admet-757	189	33	-	-	PUNCT
admet-757	189	34	014	014	NUM
admet-757	189	35	-	-	PUNCT
admet-757	189	36	3	3	NUM
admet-757	189	37	.	.	PUNCT
admet-757	189	38	estimating	estimate	VERB
admet-757	189	39	drug	drug	NOUN
admet-757	189	40	efficiency	efficiency	NOUN
admet-757	189	41	using	use	VERB
admet-757	189	42	the	the	DET
admet-757	189	43	old	old	ADJ
admet-757	189	44	and	and	CCONJ
admet-757	189	45	new	new	ADJ
admet-757	189	46	batches	batch	NOUN
admet-757	189	47	of	of	ADP
admet-757	189	48	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	189	49	columns	column	NOUN
admet-757	189	50	figure	figure	VERB
admet-757	189	51	12	12	NUM
admet-757	189	52	shows	show	VERB
admet-757	189	53	the	the	DET
admet-757	189	54	comparison	comparison	NOUN
admet-757	189	55	of	of	ADP
admet-757	189	56	the	the	DET
admet-757	189	57	estimated	estimate	VERB
admet-757	189	58	drug	drug	NOUN
admet-757	189	59	efficiency	efficiency	NOUN
admet-757	189	60	values	value	NOUN
admet-757	189	61	using	use	VERB
admet-757	189	62	the	the	DET
admet-757	189	63	old	old	ADJ
admet-757	189	64	and	and	CCONJ
admet-757	189	65	a	a	DET
admet-757	189	66	new	new	ADJ
admet-757	189	67	batch	batch	NOUN
admet-757	189	68	(	(	PUNCT
admet-757	189	69	r20511	r20511	NUM
admet-757	189	70	-	-	PUNCT
admet-757	189	71	014	014	NUM
admet-757	189	72	-	-	PUNCT
admet-757	189	73	3	3	NUM
admet-757	189	74	)	)	PUNCT
admet-757	189	75	of	of	ADP
admet-757	189	76	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	189	77	column	column	PROPN
admet-757	189	78	.	.	PUNCT
admet-757	190	1	there	there	PRON
admet-757	190	2	is	be	VERB
admet-757	190	3	good	good	ADJ
admet-757	190	4	agreement	agreement	NOUN
admet-757	190	5	between	between	ADP
admet-757	190	6	the	the	DET
admet-757	190	7	drug	drug	NOUN
admet-757	190	8	efficiency	efficiency	NOUN
admet-757	190	9	values	value	NOUN
admet-757	190	10	obtained	obtain	VERB
admet-757	190	11	on	on	ADP
admet-757	190	12	the	the	DET
admet-757	190	13	new	new	ADJ
admet-757	190	14	batch	batch	NOUN
admet-757	190	15	of	of	ADP
admet-757	190	16	the	the	DET
admet-757	190	17	iam	iam	PROPN
admet-757	190	18	column	column	NOUN
admet-757	190	19	and	and	CCONJ
admet-757	190	20	the	the	DET
admet-757	190	21	literature	literature	NOUN
admet-757	190	22	data	data	PROPN
admet-757	190	23	.	.	PUNCT
admet-757	191	1	however	however	ADV
admet-757	191	2	,	,	PUNCT
admet-757	191	3	the	the	DET
admet-757	191	4	basic	basic	ADJ
admet-757	191	5	compounds	compound	NOUN
admet-757	191	6	showed	show	VERB
admet-757	191	7	greater	great	ADJ
admet-757	191	8	drug	drug	NOUN
admet-757	191	9	efficiency	efficiency	NOUN
admet-757	191	10	than	than	SCONJ
admet-757	191	11	expected	expect	VERB
admet-757	191	12	when	when	SCONJ
admet-757	191	13	using	use	VERB
admet-757	191	14	the	the	DET
admet-757	191	15	new	new	ADJ
admet-757	191	16	batch	batch	NOUN
admet-757	191	17	(	(	PUNCT
admet-757	191	18	r20511	r20511	NUM
admet-757	191	19	-	-	PUNCT
admet-757	191	20	014	014	NUM
admet-757	191	21	-	-	PUNCT
admet-757	191	22	3	3	NUM
admet-757	191	23	)	)	PUNCT
admet-757	191	24	of	of	ADP
admet-757	191	25	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	191	26	column	column	PROPN
admet-757	191	27	.	.	PUNCT
admet-757	192	1	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	192	2	klara	klara	PROPN
admet-757	192	3	valko	valko	PROPN
admet-757	192	4	et	et	PROPN
admet-757	192	5	al	al	PROPN
admet-757	192	6	.	.	PROPN
admet-757	192	7	admet	admet	PROPN
admet-757	192	8	&	&	CCONJ
admet-757	192	9	dmpk	dmpk	PROPN
admet-757	192	10	8(1	8(1	NOUN
admet-757	192	11	)	)	PUNCT
admet-757	192	12	(	(	PUNCT
admet-757	192	13	2020	2020	NUM
admet-757	192	14	)	)	PUNCT
admet-757	192	15	78	78	NUM
admet-757	192	16	-	-	SYM
admet-757	192	17	97	97	NUM
admet-757	192	18	94	94	NUM
admet-757	192	19	figure	figure	NOUN
admet-757	192	20	12	12	NUM
admet-757	192	21	.	.	PUNCT
admet-757	193	1	the	the	DET
admet-757	193	2	plot	plot	NOUN
admet-757	193	3	of	of	ADP
admet-757	193	4	the	the	DET
admet-757	193	5	drug	drug	NOUN
admet-757	193	6	efficiency	efficiency	NOUN
admet-757	193	7	values	value	NOUN
admet-757	193	8	for	for	ADP
admet-757	193	9	the	the	DET
admet-757	193	10	investigated	investigate	VERB
admet-757	193	11	drugs	drug	NOUN
admet-757	193	12	using	use	VERB
admet-757	193	13	the	the	DET
admet-757	193	14	iam	iam	PROPN
admet-757	193	15	data	datum	NOUN
admet-757	193	16	obtained	obtain	VERB
admet-757	193	17	from	from	ADP
admet-757	193	18	the	the	DET
admet-757	193	19	reference	reference	NOUN
admet-757	193	20	(	(	PUNCT
admet-757	193	21	reference	reference	NOUN
admet-757	193	22	[	[	X
admet-757	193	23	12	12	NUM
admet-757	193	24	]	]	PUNCT
admet-757	193	25	)	)	PUNCT
admet-757	193	26	and	and	CCONJ
admet-757	193	27	by	by	ADP
admet-757	193	28	r20511	r20511	NUM
admet-757	193	29	-	-	PUNCT
admet-757	193	30	014	014	NUM
admet-757	193	31	-	-	PUNCT
admet-757	193	32	3	3	NUM
admet-757	193	33	column	column	NOUN
admet-757	193	34	in	in	ADP
admet-757	193	35	conclusion	conclusion	NOUN
admet-757	193	36	,	,	PUNCT
admet-757	193	37	some	some	DET
admet-757	193	38	differences	difference	NOUN
admet-757	193	39	between	between	ADP
admet-757	193	40	the	the	DET
admet-757	193	41	old	old	ADJ
admet-757	193	42	and	and	CCONJ
admet-757	193	43	the	the	DET
admet-757	193	44	latest	late	ADJ
admet-757	193	45	batches	batch	NOUN
admet-757	193	46	of	of	ADP
admet-757	193	47	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	193	48	columns	column	NOUN
admet-757	193	49	were	be	AUX
admet-757	193	50	observed	observe	VERB
admet-757	193	51	when	when	SCONJ
admet-757	193	52	estimating	estimate	VERB
admet-757	193	53	the	the	DET
admet-757	193	54	in	in	ADP
admet-757	193	55	vivo	vivo	ADJ
admet-757	193	56	distribution	distribution	NOUN
admet-757	193	57	of	of	ADP
admet-757	193	58	compounds	compound	NOUN
admet-757	193	59	.	.	PUNCT
admet-757	194	1	the	the	DET
admet-757	194	2	discrepancies	discrepancy	NOUN
admet-757	194	3	are	be	AUX
admet-757	194	4	more	more	ADV
admet-757	194	5	significant	significant	ADJ
admet-757	194	6	when	when	SCONJ
admet-757	194	7	the	the	DET
admet-757	194	8	models	model	NOUN
admet-757	194	9	are	be	AUX
admet-757	194	10	based	base	VERB
admet-757	194	11	on	on	ADP
admet-757	194	12	the	the	DET
admet-757	194	13	differences	difference	NOUN
admet-757	194	14	between	between	ADP
admet-757	194	15	the	the	DET
admet-757	194	16	measured	measure	VERB
admet-757	194	17	iam	iam	PROPN
admet-757	194	18	and	and	CCONJ
admet-757	194	19	hsa	hsa	X
admet-757	194	20	binding	bind	VERB
admet-757	194	21	(	(	PUNCT
admet-757	194	22	volume	volume	NOUN
admet-757	194	23	of	of	ADP
admet-757	194	24	distribution	distribution	NOUN
admet-757	194	25	)	)	PUNCT
admet-757	194	26	.	.	PUNCT
admet-757	195	1	when	when	SCONJ
admet-757	195	2	the	the	DET
admet-757	195	3	models	model	NOUN
admet-757	195	4	are	be	AUX
admet-757	195	5	based	base	VERB
admet-757	195	6	on	on	ADP
admet-757	195	7	the	the	DET
admet-757	195	8	sum	sum	NOUN
admet-757	195	9	of	of	ADP
admet-757	195	10	the	the	DET
admet-757	195	11	two	two	NUM
admet-757	195	12	types	type	NOUN
admet-757	195	13	of	of	ADP
admet-757	195	14	binding	bind	VERB
admet-757	195	15	,	,	PUNCT
admet-757	195	16	the	the	DET
admet-757	195	17	correlations	correlation	NOUN
admet-757	195	18	between	between	ADP
admet-757	195	19	the	the	DET
admet-757	195	20	estimated	estimate	VERB
admet-757	195	21	values	value	NOUN
admet-757	195	22	(	(	PUNCT
admet-757	195	23	brain	brain	NOUN
admet-757	195	24	tissue	tissue	NOUN
admet-757	195	25	binding	bind	VERB
admet-757	195	26	,	,	PUNCT
admet-757	195	27	the	the	DET
admet-757	195	28	unbound	unbound	NOUN
admet-757	195	29	volume	volume	NOUN
admet-757	195	30	of	of	ADP
admet-757	195	31	distribution	distribution	NOUN
admet-757	195	32	and	and	CCONJ
admet-757	195	33	drug	drug	NOUN
admet-757	195	34	efficiency	efficiency	NOUN
admet-757	195	35	)	)	PUNCT
admet-757	195	36	are	be	AUX
admet-757	195	37	much	much	ADV
admet-757	195	38	stronger	strong	ADJ
admet-757	195	39	.	.	PUNCT
admet-757	196	1	however	however	ADV
admet-757	196	2	,	,	PUNCT
admet-757	196	3	systematic	systematic	ADJ
admet-757	196	4	differences	difference	NOUN
admet-757	196	5	could	could	AUX
admet-757	196	6	be	be	AUX
admet-757	196	7	observed	observe	VERB
admet-757	196	8	for	for	ADP
admet-757	196	9	basic	basic	ADJ
admet-757	196	10	compounds	compound	NOUN
admet-757	196	11	in	in	ADP
admet-757	196	12	the	the	DET
admet-757	196	13	estimated	estimate	VERB
admet-757	196	14	drug	drug	NOUN
admet-757	196	15	efficiency	efficiency	NOUN
admet-757	196	16	values	value	NOUN
admet-757	196	17	.	.	PUNCT
admet-757	197	1	polar	polar	ADJ
admet-757	197	2	basic	basic	ADJ
admet-757	197	3	(	(	PUNCT
admet-757	197	4	log	log	NOUN
admet-757	197	5	p	p	NOUN
admet-757	197	6	less	less	ADJ
admet-757	197	7	than	than	ADP
admet-757	197	8	2	2	NUM
admet-757	197	9	)	)	PUNCT
admet-757	197	10	compounds	compound	VERB
admet-757	197	11	with	with	ADP
admet-757	197	12	over	over	ADP
admet-757	197	13	6	6	NUM
admet-757	197	14	rotatable	rotatable	ADJ
admet-757	197	15	bonds	bond	NOUN
admet-757	197	16	were	be	AUX
admet-757	197	17	estimated	estimate	VERB
admet-757	197	18	to	to	PART
admet-757	197	19	have	have	VERB
admet-757	197	20	greater	great	ADJ
admet-757	197	21	dug	dug	NOUN
admet-757	197	22	efficiency	efficiency	NOUN
admet-757	197	23	values	value	NOUN
admet-757	197	24	than	than	SCONJ
admet-757	197	25	previously	previously	ADV
admet-757	197	26	estimated	estimate	VERB
admet-757	197	27	using	use	VERB
admet-757	197	28	the	the	DET
admet-757	197	29	old	old	ADJ
admet-757	197	30	batches	batch	NOUN
admet-757	197	31	of	of	ADP
admet-757	197	32	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	197	33	columns	column	NOUN
admet-757	197	34	.	.	PUNCT
admet-757	198	1	these	these	DET
admet-757	198	2	discrepancies	discrepancy	NOUN
admet-757	198	3	are	be	AUX
admet-757	198	4	due	due	ADJ
admet-757	198	5	to	to	ADP
admet-757	198	6	the	the	DET
admet-757	198	7	weaker	weak	ADJ
admet-757	198	8	interaction	interaction	NOUN
admet-757	198	9	of	of	ADP
admet-757	198	10	the	the	DET
admet-757	198	11	new	new	ADJ
admet-757	198	12	batches	batch	NOUN
admet-757	198	13	of	of	ADP
admet-757	198	14	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	198	15	stationary	stationary	ADJ
admet-757	198	16	phases	phase	NOUN
admet-757	198	17	with	with	ADP
admet-757	198	18	positively	positively	ADV
admet-757	198	19	charged	charge	VERB
admet-757	198	20	basic	basic	ADJ
admet-757	198	21	compounds	compound	NOUN
admet-757	198	22	.	.	PUNCT
admet-757	199	1	this	this	PRON
admet-757	199	2	could	could	AUX
admet-757	199	3	be	be	AUX
admet-757	199	4	the	the	DET
admet-757	199	5	result	result	NOUN
admet-757	199	6	of	of	ADP
admet-757	199	7	better	well	ADJ
admet-757	199	8	endcapping	endcappe	VERB
admet-757	199	9	procedures	procedure	NOUN
admet-757	199	10	to	to	PART
admet-757	199	11	block	block	VERB
admet-757	199	12	the	the	DET
admet-757	199	13	free	free	ADJ
admet-757	199	14	silanol	silanol	NOUN
admet-757	199	15	groups	group	NOUN
admet-757	199	16	and	and	CCONJ
admet-757	199	17	it	it	PRON
admet-757	199	18	could	could	AUX
admet-757	199	19	also	also	ADV
admet-757	199	20	be	be	AUX
admet-757	199	21	due	due	ADJ
admet-757	199	22	to	to	ADP
admet-757	199	23	the	the	DET
admet-757	199	24	higher	high	ADJ
admet-757	199	25	purity	purity	NOUN
admet-757	199	26	of	of	ADP
admet-757	199	27	the	the	DET
admet-757	199	28	silica	silica	NOUN
admet-757	199	29	providing	provide	VERB
admet-757	199	30	less	less	ADV
admet-757	199	31	overall	overall	ADJ
admet-757	199	32	negatively	negatively	ADV
admet-757	199	33	charged	charge	VERB
admet-757	199	34	silanols	silanol	NOUN
admet-757	199	35	.	.	PUNCT
admet-757	200	1	based	base	VERB
admet-757	200	2	on	on	ADP
admet-757	200	3	these	these	DET
admet-757	200	4	observations	observation	NOUN
admet-757	200	5	it	it	PRON
admet-757	200	6	was	be	AUX
admet-757	200	7	decided	decide	VERB
admet-757	200	8	to	to	PART
admet-757	200	9	investigate	investigate	VERB
admet-757	200	10	the	the	DET
admet-757	200	11	potential	potential	ADJ
admet-757	200	12	benefit	benefit	NOUN
admet-757	200	13	of	of	ADP
admet-757	200	14	developing	develop	VERB
admet-757	200	15	new	new	ADJ
admet-757	200	16	models	model	NOUN
admet-757	200	17	using	use	VERB
admet-757	200	18	the	the	DET
admet-757	200	19	data	datum	NOUN
admet-757	200	20	obtained	obtain	VERB
admet-757	200	21	on	on	ADP
admet-757	200	22	the	the	DET
admet-757	200	23	new	new	ADJ
admet-757	200	24	silica	silica	NOUN
admet-757	200	25	based	base	VERB
admet-757	200	26	iam	iam	PROPN
admet-757	200	27	stationary	stationary	ADJ
admet-757	200	28	phase	phase	NOUN
admet-757	200	29	and	and	CCONJ
admet-757	200	30	to	to	PART
admet-757	200	31	compare	compare	VERB
admet-757	200	32	the	the	DET
admet-757	200	33	new	new	ADJ
admet-757	200	34	models	model	NOUN
admet-757	200	35	with	with	ADP
admet-757	200	36	the	the	DET
admet-757	200	37	existing	exist	VERB
admet-757	200	38	model	model	NOUN
admet-757	200	39	equation	equation	NOUN
admet-757	200	40	(	(	PUNCT
admet-757	200	41	equation	equation	NOUN
admet-757	200	42	4	4	NUM
admet-757	200	43	)	)	PUNCT
admet-757	200	44	.	.	PUNCT
admet-757	201	1	developing	develop	VERB
admet-757	201	2	new	new	ADJ
admet-757	201	3	distribution	distribution	NOUN
admet-757	201	4	models	model	NOUN
admet-757	201	5	using	use	VERB
admet-757	201	6	the	the	DET
admet-757	201	7	new	new	ADJ
admet-757	201	8	batches	batch	NOUN
admet-757	201	9	of	of	ADP
admet-757	201	10	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	201	11	columns	column	VERB
admet-757	201	12	the	the	DET
admet-757	201	13	correlations	correlation	NOUN
admet-757	201	14	between	between	ADP
admet-757	201	15	the	the	DET
admet-757	201	16	old	old	ADJ
admet-757	201	17	and	and	CCONJ
admet-757	201	18	the	the	DET
admet-757	201	19	new	new	ADJ
admet-757	201	20	batches	batch	NOUN
admet-757	201	21	of	of	ADP
admet-757	201	22	iam	iam	PROPN
admet-757	201	23	retention	retention	NOUN
admet-757	201	24	data	datum	NOUN
admet-757	201	25	have	have	AUX
admet-757	201	26	been	be	AUX
admet-757	201	27	investigated	investigate	VERB
admet-757	201	28	.	.	PUNCT
admet-757	202	1	it	it	PRON
admet-757	202	2	was	be	AUX
admet-757	202	3	found	find	VERB
admet-757	202	4	that	that	SCONJ
admet-757	202	5	the	the	DET
admet-757	202	6	reference	reference	NOUN
admet-757	202	7	chi	chi	NOUN
admet-757	202	8	(	(	PUNCT
admet-757	202	9	iam	iam	PROPN
admet-757	202	10	)	)	PUNCT
admet-757	202	11	data	datum	NOUN
admet-757	202	12	can	can	AUX
admet-757	202	13	be	be	AUX
admet-757	202	14	estimated	estimate	VERB
admet-757	202	15	using	use	VERB
admet-757	202	16	the	the	DET
admet-757	202	17	chi	chi	NOUN
admet-757	202	18	(	(	PUNCT
admet-757	202	19	iam	iam	PROPN
admet-757	202	20	)	)	PUNCT
admet-757	202	21	data	datum	NOUN
admet-757	202	22	obtained	obtain	VERB
admet-757	202	23	on	on	ADP
admet-757	202	24	the	the	DET
admet-757	202	25	new	new	ADJ
admet-757	202	26	batches	batch	NOUN
admet-757	202	27	(	(	PUNCT
admet-757	202	28	p20511	p20511	NOUN
admet-757	202	29	-	-	PUNCT
admet-757	202	30	014	014	NUM
admet-757	202	31	-	-	PUNCT
admet-757	202	32	3	3	NUM
admet-757	202	33	and	and	CCONJ
admet-757	202	34	r20511	r20511	NUM
admet-757	202	35	-	-	PUNCT
admet-757	202	36	014	014	NUM
admet-757	202	37	-	-	PUNCT
admet-757	202	38	3	3	NUM
admet-757	202	39	)	)	PUNCT
admet-757	202	40	of	of	ADP
admet-757	202	41	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	202	42	columns	column	NOUN
admet-757	202	43	when	when	SCONJ
admet-757	202	44	the	the	DET
admet-757	202	45	retention	retention	NOUN
admet-757	202	46	difference	difference	NOUN
admet-757	202	47	on	on	ADP
admet-757	202	48	c-18	c-18	PROPN
admet-757	202	49	columns	column	NOUN
admet-757	202	50	obtained	obtain	VERB
admet-757	202	51	at	at	ADP
admet-757	202	52	ph	ph	PROPN
admet-757	202	53	10.6	10.6	NUM
admet-757	202	54	and	and	CCONJ
admet-757	202	55	ph	ph	ADJ
admet-757	202	56	2.6	2.6	NUM
admet-757	202	57	are	be	AUX
admet-757	202	58	included	include	VERB
admet-757	202	59	in	in	ADP
admet-757	202	60	the	the	DET
admet-757	202	61	equation	equation	NOUN
admet-757	202	62	(	(	PUNCT
admet-757	202	63	equation	equation	NOUN
admet-757	202	64	(	(	PUNCT
admet-757	202	65	9	9	NUM
admet-757	202	66	)	)	PUNCT
admet-757	202	67	)	)	PUNCT
admet-757	202	68	.	.	PUNCT
admet-757	203	1	this	this	DET
admet-757	203	2	second	second	ADJ
admet-757	203	3	variable	variable	NOUN
admet-757	203	4	significantly	significantly	ADV
admet-757	203	5	increased	increase	VERB
admet-757	203	6	the	the	DET
admet-757	203	7	explained	explain	VERB
admet-757	203	8	variance	variance	NOUN
admet-757	203	9	of	of	ADP
admet-757	203	10	the	the	DET
admet-757	203	11	reference	reference	NOUN
admet-757	203	12	chi	chi	NOUN
admet-757	203	13	(	(	PUNCT
admet-757	203	14	iam	iam	PROPN
admet-757	203	15	)	)	PUNCT
admet-757	203	16	.	.	PUNCT
admet-757	204	1	reference	reference	NOUN
admet-757	204	2	chi	chi	PROPN
admet-757	204	3	(	(	PUNCT
admet-757	204	4	iam	iam	PROPN
admet-757	204	5	)	)	PUNCT
admet-757	204	6	=	=	SYM
admet-757	204	7	1.06(±0.03	1.06(±0.03	X
admet-757	204	8	)	)	PUNCT
admet-757	204	9	chi	chi	NOUN
admet-757	204	10	(	(	PUNCT
admet-757	204	11	iam	iam	PROPN
admet-757	204	12	)	)	PUNCT
admet-757	204	13	(	(	PUNCT
admet-757	204	14	r-20511	r-20511	NOUN
admet-757	204	15	-	-	PUNCT
admet-757	204	16	01403	01403	NUM
admet-757	204	17	)	)	PUNCT
admet-757	205	1	+	+	NUM
admet-757	205	2	0.008(±0.01)δchi	0.008(±0.01)δchi	X
admet-757	205	3	(	(	PUNCT
admet-757	205	4	ph10.5	ph10.5	NOUN
admet-757	205	5	ph2.6	ph2.6	NOUN
admet-757	205	6	)	)	PUNCT
admet-757	205	7	–	–	PUNCT
admet-757	205	8	1.06	1.06	NUM
admet-757	205	9	(	(	PUNCT
admet-757	205	10	±0.73	±0.73	PROPN
admet-757	205	11	)	)	PUNCT
admet-757	205	12	(	(	PUNCT
admet-757	205	13	9	9	X
admet-757	205	14	)	)	PUNCT
admet-757	205	15	n=	n=	ADJ
admet-757	205	16	67	67	NUM
admet-757	205	17	r2=0.97	r2=0.97	NOUN
admet-757	205	18	s=2.7	s=2.7	ADP
admet-757	205	19	f=1100	f=1100	PROPN
admet-757	205	20	the	the	DET
admet-757	205	21	correlation	correlation	NOUN
admet-757	205	22	was	be	AUX
admet-757	205	23	slightly	slightly	ADV
admet-757	205	24	improved	improve	VERB
admet-757	205	25	(	(	PUNCT
admet-757	205	26	from	from	ADP
admet-757	205	27	0.92	0.92	NUM
admet-757	205	28	to	to	ADP
admet-757	205	29	0.97	0.97	NUM
admet-757	205	30	)	)	PUNCT
admet-757	205	31	between	between	ADP
admet-757	205	32	the	the	DET
admet-757	205	33	reference	reference	NOUN
admet-757	205	34	chi	chi	NOUN
admet-757	205	35	(	(	PUNCT
admet-757	205	36	iam	iam	PROPN
admet-757	205	37	)	)	PUNCT
admet-757	205	38	values	value	NOUN
admet-757	205	39	and	and	CCONJ
admet-757	205	40	the	the	DET
admet-757	205	41	chi	chi	NOUN
admet-757	205	42	(	(	PUNCT
admet-757	205	43	iam	iam	PROPN
admet-757	205	44	)	)	PUNCT
admet-757	205	45	values	value	NOUN
admet-757	205	46	obtained	obtain	VERB
admet-757	205	47	on	on	ADP
admet-757	205	48	the	the	DET
admet-757	205	49	new	new	ADJ
admet-757	205	50	batch	batch	NOUN
admet-757	205	51	of	of	ADP
admet-757	205	52	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	205	53	columns	column	NOUN
admet-757	205	54	.	.	PUNCT
admet-757	206	1	however	however	ADV
admet-757	206	2	,	,	PUNCT
admet-757	206	3	in	in	ADP
admet-757	206	4	order	order	NOUN
admet-757	206	5	to	to	PART
admet-757	206	6	be	be	AUX
admet-757	206	7	able	able	ADJ
admet-757	206	8	to	to	PART
admet-757	206	9	use	use	VERB
admet-757	206	10	equation	equation	NOUN
admet-757	206	11	9	9	NUM
admet-757	206	12	,	,	PUNCT
admet-757	206	13	the	the	DET
admet-757	206	14	chi	chi	ADJ
admet-757	206	15	measurements	measurement	NOUN
admet-757	206	16	on	on	ADP
admet-757	206	17	c-18	c-18	NOUN
admet-757	206	18	columns	column	NOUN
admet-757	206	19	should	should	AUX
admet-757	206	20	be	be	AUX
admet-757	206	21	carried	carry	VERB
admet-757	206	22	out	out	ADP
admet-757	206	23	at	at	ADP
admet-757	206	24	high	high	ADJ
admet-757	206	25	and	and	CCONJ
admet-757	206	26	low	low	ADJ
admet-757	206	27	ph	ph	VERB
admet-757	206	28	.	.	PROPN
admet-757	207	1	this	this	DET
admet-757	207	2	admet	admet	PROPN
admet-757	207	3	&	&	CCONJ
admet-757	207	4	dmpk	dmpk	PROPN
admet-757	207	5	8(1	8(1	NOUN
admet-757	207	6	)	)	PUNCT
admet-757	207	7	(	(	PUNCT
admet-757	207	8	2020	2020	NUM
admet-757	207	9	)	)	PUNCT
admet-757	207	10	78	78	NUM
admet-757	207	11	-	-	SYM
admet-757	207	12	97	97	NUM
admet-757	207	13	revisiting	revisit	VERB
admet-757	207	14	the	the	DET
admet-757	207	15	iam	iam	PROPN
admet-757	207	16	chromatography	chromatography	NOUN
admet-757	207	17	doi	doi	PROPN
admet-757	207	18	:	:	PUNCT
admet-757	207	19	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	207	20	95	95	NUM
admet-757	207	21	requires	require	VERB
admet-757	207	22	two	two	NUM
admet-757	207	23	additional	additional	ADJ
admet-757	207	24	measurements	measurement	NOUN
admet-757	207	25	for	for	ADP
admet-757	207	26	each	each	DET
admet-757	207	27	compound	compound	NOUN
admet-757	207	28	.	.	PUNCT
admet-757	208	1	when	when	SCONJ
admet-757	208	2	resources	resource	NOUN
admet-757	208	3	are	be	AUX
admet-757	208	4	limited	limit	VERB
admet-757	208	5	,	,	PUNCT
admet-757	208	6	the	the	DET
admet-757	208	7	calculated	calculated	ADJ
admet-757	208	8	molecular	molecular	ADJ
admet-757	208	9	descriptor	descriptor	NOUN
admet-757	208	10	can	can	AUX
admet-757	208	11	be	be	AUX
admet-757	208	12	used	use	VERB
admet-757	208	13	.	.	PUNCT
admet-757	209	1	the	the	DET
admet-757	209	2	following	follow	VERB
admet-757	209	3	parameters	parameter	NOUN
admet-757	209	4	have	have	AUX
admet-757	209	5	been	be	AUX
admet-757	209	6	calculated	calculate	VERB
admet-757	209	7	for	for	ADP
admet-757	209	8	the	the	DET
admet-757	209	9	investigated	investigate	VERB
admet-757	209	10	drug	drug	NOUN
admet-757	209	11	molecules	molecule	NOUN
admet-757	209	12	:	:	PUNCT
admet-757	209	13	log	log	VERB
admet-757	209	14	p	p	NOUN
admet-757	209	15	,	,	PUNCT
admet-757	209	16	molecular	molecular	ADJ
admet-757	209	17	weight	weight	NOUN
admet-757	209	18	,	,	PUNCT
admet-757	209	19	number	number	NOUN
admet-757	209	20	of	of	ADP
admet-757	209	21	h	h	NOUN
admet-757	209	22	-	-	PUNCT
admet-757	209	23	bond	bond	NOUN
admet-757	209	24	donor	donor	NOUN
admet-757	209	25	and	and	CCONJ
admet-757	209	26	acceptor	acceptor	NOUN
admet-757	209	27	groups	group	NOUN
admet-757	209	28	,	,	PUNCT
admet-757	209	29	total	total	ADJ
admet-757	209	30	polar	polar	ADJ
admet-757	209	31	surface	surface	NOUN
admet-757	209	32	area	area	NOUN
admet-757	209	33	,	,	PUNCT
admet-757	209	34	flexibility	flexibility	NOUN
admet-757	209	35	and	and	CCONJ
admet-757	209	36	the	the	DET
admet-757	209	37	number	number	NOUN
admet-757	209	38	of	of	ADP
admet-757	209	39	rotatable	rotatable	ADJ
admet-757	209	40	bonds	bond	NOUN
admet-757	209	41	(	(	PUNCT
admet-757	209	42	nrb	nrb	NOUN
admet-757	209	43	)	)	PUNCT
admet-757	209	44	.	.	PUNCT
admet-757	210	1	it	it	PRON
admet-757	210	2	was	be	AUX
admet-757	210	3	found	find	VERB
admet-757	210	4	that	that	SCONJ
admet-757	210	5	the	the	DET
admet-757	210	6	only	only	ADJ
admet-757	210	7	significant	significant	ADJ
admet-757	210	8	variables	variable	NOUN
admet-757	210	9	among	among	ADP
admet-757	210	10	the	the	DET
admet-757	210	11	calculated	calculated	ADJ
admet-757	210	12	parameters	parameter	NOUN
admet-757	210	13	that	that	PRON
admet-757	210	14	improved	improve	VERB
admet-757	210	15	the	the	DET
admet-757	210	16	correlation	correlation	NOUN
admet-757	210	17	between	between	ADP
admet-757	210	18	the	the	DET
admet-757	210	19	chi	chi	NOUN
admet-757	210	20	(	(	PUNCT
admet-757	210	21	iam	iam	PROPN
admet-757	210	22	)	)	PUNCT
admet-757	210	23	values	value	NOUN
admet-757	210	24	obtained	obtain	VERB
admet-757	210	25	using	use	VERB
admet-757	210	26	the	the	DET
admet-757	210	27	new	new	ADJ
admet-757	210	28	and	and	CCONJ
admet-757	210	29	old	old	ADJ
admet-757	210	30	batches	batch	NOUN
admet-757	210	31	of	of	ADP
admet-757	210	32	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	210	33	columns	column	NOUN
admet-757	210	34	were	be	AUX
admet-757	210	35	clogp	clogp	ADJ
admet-757	210	36	and	and	CCONJ
admet-757	210	37	the	the	DET
admet-757	210	38	total	total	ADJ
admet-757	210	39	polar	polar	ADJ
admet-757	210	40	surface	surface	NOUN
admet-757	210	41	area	area	NOUN
admet-757	210	42	(	(	PUNCT
admet-757	210	43	tpsa	tpsa	NOUN
admet-757	210	44	)	)	PUNCT
admet-757	210	45	as	as	SCONJ
admet-757	210	46	shown	show	VERB
admet-757	210	47	in	in	ADP
admet-757	210	48	equation	equation	NOUN
admet-757	210	49	10	10	NUM
admet-757	210	50	.	.	PUNCT
admet-757	211	1	however	however	ADV
admet-757	211	2	,	,	PUNCT
admet-757	211	3	the	the	DET
admet-757	211	4	correlation	correlation	NOUN
admet-757	211	5	coefficient	coefficient	NOUN
admet-757	211	6	improved	improve	VERB
admet-757	211	7	only	only	ADV
admet-757	211	8	slightly	slightly	ADV
admet-757	211	9	from	from	ADP
admet-757	211	10	0.92	0.92	NUM
admet-757	211	11	to	to	ADP
admet-757	211	12	0.96	0.96	NUM
admet-757	211	13	.	.	PUNCT
admet-757	212	1	reference	reference	NOUN
admet-757	212	2	chi	chi	NOUN
admet-757	212	3	(	(	PUNCT
admet-757	212	4	iam)=1.38(±0.07	iam)=1.38(±0.07	NOUN
admet-757	212	5	)	)	PUNCT
admet-757	212	6	chi	chi	NOUN
admet-757	212	7	(	(	PUNCT
admet-757	212	8	iam)(r20511	iam)(r20511	PROPN
admet-757	212	9	–	–	PUNCT
admet-757	212	10	014	014	NUM
admet-757	212	11	-3	-3	NUM
admet-757	212	12	)	)	PUNCT
admet-757	212	13	–	–	PUNCT
admet-757	212	14	2.42(±0.57	2.42(±0.57	NUM
admet-757	212	15	)	)	PUNCT
admet-757	212	16	clogp	clogp	ADJ
admet-757	212	17	-0.03(±0.01	-0.03(±0.01	NOUN
admet-757	212	18	)	)	PUNCT
admet-757	212	19	tpsa	tpsa	NOUN
admet-757	212	20	1.28	1.28	NUM
admet-757	212	21	(	(	PUNCT
admet-757	212	22	10	10	NUM
admet-757	212	23	)	)	PUNCT
admet-757	213	1	n=68	n=68	ADV
admet-757	213	2	r	r	NOUN
admet-757	213	3	2	2	NUM
admet-757	213	4	=	=	SYM
admet-757	213	5	0.96	0.96	NUM
admet-757	213	6	s=3.3	s=3.3	NOUN
admet-757	213	7	f=530	f=530	PROPN
admet-757	213	8	the	the	DET
admet-757	213	9	other	other	ADJ
admet-757	213	10	option	option	NOUN
admet-757	213	11	was	be	AUX
admet-757	213	12	to	to	PART
admet-757	213	13	build	build	VERB
admet-757	213	14	a	a	DET
admet-757	213	15	new	new	ADJ
admet-757	213	16	model	model	NOUN
admet-757	213	17	for	for	ADP
admet-757	213	18	the	the	DET
admet-757	213	19	estimation	estimation	NOUN
admet-757	213	20	of	of	ADP
admet-757	213	21	the	the	DET
admet-757	213	22	volume	volume	NOUN
admet-757	213	23	of	of	ADP
admet-757	213	24	distribution	distribution	NOUN
admet-757	213	25	using	use	VERB
admet-757	213	26	the	the	DET
admet-757	213	27	new	new	ADJ
admet-757	213	28	batches	batch	NOUN
admet-757	213	29	of	of	ADP
admet-757	213	30	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	213	31	columns	column	NOUN
admet-757	213	32	and	and	CCONJ
admet-757	213	33	the	the	DET
admet-757	213	34	clinical	clinical	ADJ
admet-757	213	35	volume	volume	NOUN
admet-757	213	36	of	of	ADP
admet-757	213	37	distribution	distribution	NOUN
admet-757	213	38	data	datum	NOUN
admet-757	213	39	.	.	PUNCT
admet-757	214	1	the	the	DET
admet-757	214	2	new	new	ADJ
admet-757	214	3	equation	equation	NOUN
admet-757	214	4	for	for	ADP
admet-757	214	5	modelling	model	VERB
admet-757	214	6	clinical	clinical	ADJ
admet-757	214	7	steady	steady	ADJ
admet-757	214	8	-	-	PUNCT
admet-757	214	9	state	state	NOUN
admet-757	214	10	volume	volume	NOUN
admet-757	214	11	of	of	ADP
admet-757	214	12	distribution	distribution	NOUN
admet-757	214	13	data	datum	NOUN
admet-757	214	14	is	be	AUX
admet-757	214	15	shown	show	VERB
admet-757	214	16	in	in	ADP
admet-757	214	17	equation	equation	NOUN
admet-757	214	18	11	11	NUM
admet-757	214	19	.	.	PUNCT
admet-757	215	1	the	the	DET
admet-757	215	2	mathematical	mathematical	ADJ
admet-757	215	3	-	-	PUNCT
admet-757	215	4	statistical	statistical	ADJ
admet-757	215	5	parameters	parameter	NOUN
admet-757	215	6	are	be	AUX
admet-757	215	7	very	very	ADV
admet-757	215	8	similar	similar	ADJ
admet-757	215	9	to	to	ADP
admet-757	215	10	the	the	DET
admet-757	215	11	original	original	ADJ
admet-757	215	12	equation	equation	NOUN
admet-757	215	13	(	(	PUNCT
admet-757	215	14	equation	equation	NOUN
admet-757	215	15	4	4	NUM
admet-757	215	16	)	)	PUNCT
admet-757	215	17	;	;	PUNCT
admet-757	215	18	however	however	ADV
admet-757	215	19	,	,	PUNCT
admet-757	215	20	the	the	DET
admet-757	215	21	coefficients	coefficient	NOUN
admet-757	215	22	of	of	ADP
admet-757	215	23	the	the	DET
admet-757	215	24	iam	iam	PROPN
admet-757	215	25	and	and	CCONJ
admet-757	215	26	hsa	hsa	VERB
admet-757	215	27	binding	bind	VERB
admet-757	215	28	data	datum	NOUN
admet-757	215	29	are	be	AUX
admet-757	215	30	very	very	ADV
admet-757	215	31	different	different	ADJ
admet-757	215	32	.	.	PUNCT
admet-757	216	1	log	log	VERB
admet-757	216	2	vdss	vdss	ADV
admet-757	216	3	clinical	clinical	ADJ
admet-757	216	4	=	=	NOUN
admet-757	216	5	0.54(±0.04	0.54(±0.04	NOUN
admet-757	216	6	)	)	PUNCT
admet-757	216	7	log	log	NOUN
admet-757	216	8	k	k	PROPN
admet-757	216	9	(	(	PUNCT
admet-757	216	10	iam)(r20511	iam)(r20511	PROPN
admet-757	216	11	-	-	PUNCT
admet-757	216	12	01403	01403	NUM
admet-757	216	13	)	)	PUNCT
admet-757	216	14	0.24(±0.02	0.24(±0.02	PROPN
admet-757	216	15	)	)	PUNCT
admet-757	217	1	log	log	NOUN
admet-757	217	2	k	k	PROPN
admet-757	217	3	(	(	PUNCT
admet-757	217	4	hsa	hsa	PROPN
admet-757	217	5	)	)	PUNCT
admet-757	217	6	-0.7	-0.7	PROPN
admet-757	217	7	(	(	PUNCT
admet-757	217	8	11	11	NUM
admet-757	217	9	)	)	PUNCT
admet-757	217	10	n=72	n=72	NOUN
admet-757	217	11	r2=0.78	r2=0.78	X
admet-757	217	12	s=0.30	s=0.30	VERB
admet-757	217	13	the	the	DET
admet-757	217	14	plot	plot	NOUN
admet-757	217	15	of	of	ADP
admet-757	217	16	the	the	DET
admet-757	217	17	estimated	estimate	VERB
admet-757	217	18	and	and	CCONJ
admet-757	217	19	measured	measure	VERB
admet-757	217	20	clinical	clinical	ADJ
admet-757	217	21	steady	steady	ADJ
admet-757	217	22	-	-	PUNCT
admet-757	217	23	state	state	NOUN
admet-757	217	24	volume	volume	NOUN
admet-757	217	25	of	of	ADP
admet-757	217	26	distribution	distribution	NOUN
admet-757	217	27	data	datum	NOUN
admet-757	217	28	are	be	AUX
admet-757	217	29	shown	show	VERB
admet-757	217	30	in	in	ADP
admet-757	217	31	figure	figure	NOUN
admet-757	217	32	13	13	NUM
admet-757	217	33	.	.	PUNCT
admet-757	218	1	when	when	SCONJ
admet-757	218	2	comparing	compare	VERB
admet-757	218	3	the	the	DET
admet-757	218	4	coefficients	coefficient	NOUN
admet-757	218	5	of	of	ADP
admet-757	218	6	equation	equation	NOUN
admet-757	218	7	4	4	NUM
admet-757	218	8	(	(	PUNCT
admet-757	218	9	the	the	DET
admet-757	218	10	published	publish	VERB
admet-757	218	11	vdss	vdss	ADJ
admet-757	218	12	model	model	NOUN
admet-757	218	13	equation	equation	NOUN
admet-757	218	14	)	)	PUNCT
admet-757	218	15	and	and	CCONJ
admet-757	218	16	equation	equation	NOUN
admet-757	218	17	10	10	NUM
admet-757	218	18	,	,	PUNCT
admet-757	218	19	it	it	PRON
admet-757	218	20	can	can	AUX
admet-757	218	21	be	be	AUX
admet-757	218	22	seen	see	VERB
admet-757	218	23	that	that	SCONJ
admet-757	218	24	the	the	DET
admet-757	218	25	coefficients	coefficient	NOUN
admet-757	218	26	for	for	ADP
admet-757	218	27	the	the	DET
admet-757	218	28	hsa	hsa	PROPN
admet-757	218	29	binding	bind	VERB
admet-757	218	30	do	do	AUX
admet-757	218	31	not	not	PART
admet-757	218	32	differ	differ	VERB
admet-757	218	33	significantly	significantly	ADV
admet-757	218	34	(	(	PUNCT
admet-757	218	35	0.24	0.24	NUM
admet-757	218	36	and	and	CCONJ
admet-757	218	37	0.22	0.22	NUM
admet-757	218	38	with	with	ADP
admet-757	218	39	an	an	DET
admet-757	218	40	error	error	NOUN
admet-757	218	41	of	of	ADP
admet-757	218	42	0.02	0.02	NUM
admet-757	218	43	)	)	PUNCT
admet-757	218	44	.	.	PUNCT
admet-757	219	1	however	however	ADV
admet-757	219	2	,	,	PUNCT
admet-757	219	3	the	the	DET
admet-757	219	4	coefficients	coefficient	NOUN
admet-757	219	5	of	of	ADP
admet-757	219	6	log	log	NOUN
admet-757	219	7	k	k	PROPN
admet-757	219	8	(	(	PUNCT
admet-757	219	9	iam	iam	PROPN
admet-757	219	10	)	)	PUNCT
admet-757	219	11	are	be	AUX
admet-757	219	12	different	different	ADJ
admet-757	219	13	at	at	ADP
admet-757	219	14	the	the	DET
admet-757	219	15	95	95	NUM
admet-757	219	16	%	%	NOUN
admet-757	219	17	confidence	confidence	NOUN
admet-757	219	18	interval	interval	NOUN
admet-757	219	19	and	and	CCONJ
admet-757	219	20	agree	agree	VERB
admet-757	219	21	only	only	ADV
admet-757	219	22	within	within	ADP
admet-757	219	23	a	a	DET
admet-757	219	24	90	90	NUM
admet-757	219	25	%	%	NOUN
admet-757	219	26	confidence	confidence	NOUN
admet-757	219	27	interval	interval	NOUN
admet-757	219	28	:	:	PUNCT
admet-757	219	29	0.54	0.54	NUM
admet-757	219	30	±	±	NUM
admet-757	219	31	0.04	0.04	NUM
admet-757	219	32	and	and	CCONJ
admet-757	219	33	0.44	0.44	NUM
admet-757	219	34	±	±	NUM
admet-757	219	35	0.02	0.02	NUM
admet-757	219	36	.	.	PUNCT
admet-757	220	1	figure	figure	NOUN
admet-757	220	2	13	13	NUM
admet-757	220	3	.	.	PUNCT
admet-757	221	1	the	the	DET
admet-757	221	2	plot	plot	NOUN
admet-757	221	3	of	of	ADP
admet-757	221	4	the	the	DET
admet-757	221	5	calculated	calculate	VERB
admet-757	221	6	log	log	NOUN
admet-757	221	7	vdss	vdss	ADJ
admet-757	221	8	values	value	NOUN
admet-757	221	9	using	use	VERB
admet-757	221	10	the	the	DET
admet-757	221	11	new	new	ADJ
admet-757	221	12	model	model	NOUN
admet-757	221	13	with	with	ADP
admet-757	221	14	the	the	DET
admet-757	221	15	chi	chi	NOUN
admet-757	221	16	(	(	PUNCT
admet-757	221	17	iam	iam	PROPN
admet-757	221	18	)	)	PUNCT
admet-757	221	19	values	value	NOUN
admet-757	221	20	obtained	obtain	VERB
admet-757	221	21	on	on	ADP
admet-757	221	22	column	column	NOUN
admet-757	221	23	(	(	PUNCT
admet-757	221	24	r20511	r20511	NUM
admet-757	221	25	-	-	PUNCT
admet-757	221	26	014	014	NUM
admet-757	221	27	-	-	PUNCT
admet-757	221	28	3	3	NUM
admet-757	221	29	)	)	PUNCT
admet-757	221	30	as	as	ADP
admet-757	221	31	a	a	DET
admet-757	221	32	function	function	NOUN
admet-757	221	33	of	of	ADP
admet-757	221	34	the	the	DET
admet-757	221	35	clinical	clinical	ADJ
admet-757	221	36	log	log	NOUN
admet-757	221	37	vdss	vdss	ADJ
admet-757	221	38	values	value	NOUN
admet-757	221	39	.	.	PUNCT
admet-757	222	1	conclusions	conclusion	NOUN
admet-757	222	2	the	the	DET
admet-757	222	3	use	use	NOUN
admet-757	222	4	of	of	ADP
admet-757	222	5	a	a	DET
admet-757	222	6	new	new	ADJ
admet-757	222	7	silica	silica	NOUN
admet-757	222	8	support	support	NOUN
admet-757	222	9	provided	provide	VERB
admet-757	222	10	a	a	DET
admet-757	222	11	slightly	slightly	ADV
admet-757	222	12	different	different	ADJ
admet-757	222	13	selectivity	selectivity	NOUN
admet-757	222	14	for	for	ADP
admet-757	222	15	the	the	DET
admet-757	222	16	new	new	ADJ
admet-757	222	17	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	222	18	columns	column	NOUN
admet-757	222	19	regardless	regardless	ADV
admet-757	222	20	of	of	ADP
admet-757	222	21	the	the	DET
admet-757	222	22	bonding	bonding	NOUN
admet-757	222	23	procedure	procedure	NOUN
admet-757	222	24	used	use	VERB
admet-757	222	25	.	.	PUNCT
admet-757	223	1	therefore	therefore	ADV
admet-757	223	2	,	,	PUNCT
admet-757	223	3	new	new	ADJ
admet-757	223	4	chi	chi	NOUN
admet-757	223	5	(	(	PUNCT
admet-757	223	6	iam	iam	PROPN
admet-757	223	7	)	)	PUNCT
admet-757	223	8	values	value	NOUN
admet-757	223	9	have	have	AUX
admet-757	223	10	been	be	AUX
admet-757	223	11	proposed	propose	VERB
admet-757	223	12	for	for	ADP
admet-757	223	13	the	the	DET
admet-757	223	14	system	system	NOUN
admet-757	223	15	suitability	suitability	NOUN
admet-757	223	16	test	test	NOUN
admet-757	223	17	compounds	compound	VERB
admet-757	223	18	.	.	PUNCT
admet-757	224	1	new	new	ADJ
admet-757	224	2	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	224	3	columns	column	NOUN
admet-757	224	4	should	should	AUX
admet-757	224	5	be	be	AUX
admet-757	224	6	evaluated	evaluate	VERB
admet-757	224	7	using	use	VERB
admet-757	224	8	the	the	DET
admet-757	224	9	new	new	ADJ
admet-757	224	10	chi	chi	NOUN
admet-757	224	11	(	(	PUNCT
admet-757	224	12	iam	iam	PROPN
admet-757	224	13	)	)	PUNCT
admet-757	224	14	values	value	NOUN
admet-757	224	15	(	(	PUNCT
admet-757	224	16	table	table	NOUN
admet-757	224	17	4	4	NUM
admet-757	224	18	.	.	PUNCT
admet-757	224	19	)	)	PUNCT
admet-757	224	20	.	.	PUNCT
admet-757	225	1	the	the	DET
admet-757	225	2	reproducibility	reproducibility	NOUN
admet-757	225	3	of	of	ADP
admet-757	225	4	the	the	DET
admet-757	225	5	new	new	ADJ
admet-757	225	6	batches	batch	NOUN
admet-757	225	7	of	of	ADP
admet-757	225	8	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	225	9	columns	column	NOUN
admet-757	225	10	are	be	AUX
admet-757	225	11	very	very	ADV
admet-757	225	12	good	good	ADJ
admet-757	225	13	and	and	CCONJ
admet-757	225	14	are	be	AUX
admet-757	225	15	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	PROPN
admet-757	226	1	klara	klara	PROPN
admet-757	226	2	valko	valko	PROPN
admet-757	226	3	et	et	PROPN
admet-757	226	4	al	al	PROPN
admet-757	226	5	.	.	PROPN
admet-757	226	6	admet	admet	PROPN
admet-757	226	7	&	&	CCONJ
admet-757	226	8	dmpk	dmpk	PROPN
admet-757	226	9	8(1	8(1	NOUN
admet-757	226	10	)	)	PUNCT
admet-757	226	11	(	(	PUNCT
admet-757	226	12	2020	2020	NUM
admet-757	226	13	)	)	PUNCT
admet-757	226	14	78	78	NUM
admet-757	226	15	-	-	SYM
admet-757	226	16	97	97	NUM
admet-757	226	17	96	96	NUM
admet-757	226	18	within	within	ADP
admet-757	226	19	2	2	NUM
admet-757	226	20	chi	chi	NOUN
admet-757	226	21	(	(	PUNCT
admet-757	226	22	iam	iam	PROPN
admet-757	226	23	)	)	PUNCT
admet-757	226	24	units	unit	NOUN
admet-757	226	25	.	.	PUNCT
admet-757	227	1	the	the	DET
admet-757	227	2	effect	effect	NOUN
admet-757	227	3	of	of	ADP
admet-757	227	4	the	the	DET
admet-757	227	5	selectivity	selectivity	NOUN
admet-757	227	6	change	change	NOUN
admet-757	227	7	has	have	AUX
admet-757	227	8	been	be	AUX
admet-757	227	9	investigated	investigate	VERB
admet-757	227	10	on	on	ADP
admet-757	227	11	previously	previously	ADV
admet-757	227	12	developed	develop	VERB
admet-757	227	13	in	in	ADP
admet-757	227	14	vivo	vivo	NOUN
admet-757	227	15	models	model	NOUN
admet-757	227	16	for	for	ADP
admet-757	227	17	drug	drug	NOUN
admet-757	227	18	distribution	distribution	NOUN
admet-757	227	19	that	that	PRON
admet-757	227	20	are	be	AUX
admet-757	227	21	based	base	VERB
admet-757	227	22	on	on	ADP
admet-757	227	23	chi	chi	PROPN
admet-757	227	24	(	(	PUNCT
admet-757	227	25	iam	iam	PROPN
admet-757	227	26	)	)	PUNCT
admet-757	227	27	values	value	NOUN
admet-757	227	28	.	.	PUNCT
admet-757	228	1	a	a	DET
admet-757	228	2	set	set	NOUN
admet-757	228	3	of	of	ADP
admet-757	228	4	72	72	NUM
admet-757	228	5	marketed	market	VERB
admet-757	228	6	drugs	drug	NOUN
admet-757	228	7	with	with	ADP
admet-757	228	8	clinical	clinical	ADJ
admet-757	228	9	distribution	distribution	NOUN
admet-757	228	10	data	datum	NOUN
admet-757	228	11	(	(	PUNCT
admet-757	228	12	volume	volume	NOUN
admet-757	228	13	of	of	ADP
admet-757	228	14	distribution	distribution	NOUN
admet-757	228	15	,	,	PUNCT
admet-757	228	16	unbound	unbound	NOUN
admet-757	228	17	volume	volume	NOUN
admet-757	228	18	of	of	ADP
admet-757	228	19	distribution	distribution	NOUN
admet-757	228	20	and	and	CCONJ
admet-757	228	21	drug	drug	NOUN
admet-757	228	22	efficiency	efficiency	NOUN
admet-757	228	23	)	)	PUNCT
admet-757	228	24	have	have	AUX
admet-757	228	25	been	be	AUX
admet-757	228	26	analyzed	analyze	VERB
admet-757	228	27	on	on	ADP
admet-757	228	28	the	the	DET
admet-757	228	29	new	new	ADJ
admet-757	228	30	batches	batch	NOUN
admet-757	228	31	of	of	ADP
admet-757	228	32	iam	iam	PROPN
admet-757	228	33	columns	column	NOUN
admet-757	228	34	.	.	PUNCT
admet-757	229	1	the	the	DET
admet-757	229	2	chi	chi	PROPN
admet-757	229	3	(	(	PUNCT
admet-757	229	4	iam	iam	PROPN
admet-757	229	5	)	)	PUNCT
admet-757	229	6	values	value	NOUN
admet-757	229	7	were	be	AUX
admet-757	229	8	compared	compare	VERB
admet-757	229	9	with	with	ADP
admet-757	229	10	the	the	DET
admet-757	229	11	values	value	NOUN
admet-757	229	12	obtained	obtain	VERB
admet-757	229	13	from	from	ADP
admet-757	229	14	the	the	DET
admet-757	229	15	previous	previous	ADJ
admet-757	229	16	batches	batch	NOUN
admet-757	229	17	of	of	ADP
admet-757	229	18	iam	iam	PROPN
admet-757	229	19	columns	column	NOUN
admet-757	229	20	and	and	CCONJ
admet-757	229	21	it	it	PRON
admet-757	229	22	was	be	AUX
admet-757	229	23	observed	observe	VERB
admet-757	229	24	that	that	SCONJ
admet-757	229	25	small	small	ADJ
admet-757	229	26	polar	polar	ADJ
admet-757	229	27	basic	basic	ADJ
admet-757	229	28	compounds	compound	NOUN
admet-757	229	29	showed	show	VERB
admet-757	229	30	significantly	significantly	ADV
admet-757	229	31	shorter	short	ADJ
admet-757	229	32	retention	retention	NOUN
admet-757	229	33	times	time	NOUN
admet-757	229	34	on	on	ADP
admet-757	229	35	the	the	DET
admet-757	229	36	new	new	ADJ
admet-757	229	37	iam.pc.dd2	iam.pc.dd2	PROPN
admet-757	229	38	columns	column	NOUN
admet-757	229	39	.	.	PUNCT
admet-757	230	1	the	the	DET
admet-757	230	2	correlation	correlation	NOUN
admet-757	230	3	coefficient	coefficient	NOUN
admet-757	230	4	improved	improve	VERB
admet-757	230	5	significantly	significantly	ADV
admet-757	230	6	when	when	SCONJ
admet-757	230	7	the	the	DET
admet-757	230	8	data	datum	NOUN
admet-757	230	9	from	from	ADP
admet-757	230	10	these	these	DET
admet-757	230	11	compounds	compound	NOUN
admet-757	230	12	are	be	AUX
admet-757	230	13	removed	remove	VERB
admet-757	230	14	from	from	ADP
admet-757	230	15	the	the	DET
admet-757	230	16	analysis	analysis	NOUN
admet-757	230	17	.	.	PUNCT
admet-757	231	1	the	the	DET
admet-757	231	2	possible	possible	ADJ
admet-757	231	3	reason	reason	NOUN
admet-757	231	4	for	for	ADP
admet-757	231	5	these	these	DET
admet-757	231	6	discrepancies	discrepancy	NOUN
admet-757	231	7	may	may	AUX
admet-757	231	8	be	be	AUX
admet-757	231	9	due	due	ADJ
admet-757	231	10	to	to	ADP
admet-757	231	11	the	the	DET
admet-757	231	12	better	well	ADJ
admet-757	231	13	endcapping	endcappe	VERB
admet-757	231	14	procedure	procedure	NOUN
admet-757	231	15	on	on	ADP
admet-757	231	16	the	the	DET
admet-757	231	17	new	new	ADJ
admet-757	231	18	iam	iam	PROPN
admet-757	231	19	columns	column	NOUN
admet-757	231	20	which	which	PRON
admet-757	231	21	is	be	AUX
admet-757	231	22	blocking	block	VERB
admet-757	231	23	the	the	DET
admet-757	231	24	silanol	silanol	NOUN
admet-757	231	25	effects	effect	NOUN
admet-757	231	26	that	that	PRON
admet-757	231	27	increase	increase	VERB
admet-757	231	28	retention	retention	NOUN
admet-757	231	29	of	of	ADP
admet-757	231	30	basic	basic	ADJ
admet-757	231	31	compounds	compound	NOUN
admet-757	231	32	.	.	PUNCT
admet-757	232	1	it	it	PRON
admet-757	232	2	is	be	AUX
admet-757	232	3	also	also	ADV
admet-757	232	4	likely	likely	ADJ
admet-757	232	5	that	that	SCONJ
admet-757	232	6	the	the	DET
admet-757	232	7	newer	new	ADJ
admet-757	232	8	“	"	PUNCT
admet-757	232	9	type	type	NOUN
admet-757	232	10	b	b	NOUN
admet-757	232	11	”	"	PUNCT
admet-757	232	12	silica	silica	NOUN
admet-757	232	13	is	be	AUX
admet-757	232	14	higher	high	ADJ
admet-757	232	15	purity	purity	NOUN
admet-757	232	16	silica	silica	NOUN
admet-757	232	17	with	with	ADP
admet-757	232	18	a	a	DET
admet-757	232	19	more	more	ADV
admet-757	232	20	inert	inert	ADJ
admet-757	232	21	surface	surface	NOUN
admet-757	232	22	and	and	CCONJ
admet-757	232	23	creates	create	VERB
admet-757	232	24	fewer	few	ADJ
admet-757	232	25	negatively	negatively	ADV
admet-757	232	26	charged	charge	VERB
admet-757	232	27	silanols	silanol	NOUN
admet-757	232	28	decreasing	decrease	VERB
admet-757	232	29	the	the	DET
admet-757	232	30	amount	amount	NOUN
admet-757	232	31	of	of	ADP
admet-757	232	32	non	non	ADJ
admet-757	232	33	-	-	ADJ
admet-757	232	34	specific	specific	ADJ
admet-757	232	35	binding	binding	NOUN
admet-757	232	36	.	.	PUNCT
admet-757	233	1	it	it	PRON
admet-757	233	2	was	be	AUX
admet-757	233	3	found	find	VERB
admet-757	233	4	that	that	SCONJ
admet-757	233	5	using	use	VERB
admet-757	233	6	the	the	DET
admet-757	233	7	new	new	ADJ
admet-757	233	8	chi	chi	NOUN
admet-757	233	9	(	(	PUNCT
admet-757	233	10	iam	iam	PROPN
admet-757	233	11	)	)	PUNCT
admet-757	233	12	data	datum	NOUN
admet-757	233	13	in	in	ADP
admet-757	233	14	the	the	DET
admet-757	233	15	previously	previously	ADV
admet-757	233	16	published	publish	VERB
admet-757	233	17	model	model	NOUN
admet-757	233	18	equations	equation	NOUN
admet-757	233	19	,	,	PUNCT
admet-757	233	20	a	a	DET
admet-757	233	21	good	good	ADJ
admet-757	233	22	correlation	correlation	NOUN
admet-757	233	23	was	be	AUX
admet-757	233	24	obtained	obtain	VERB
admet-757	233	25	with	with	ADP
admet-757	233	26	the	the	DET
admet-757	233	27	original	original	ADJ
admet-757	233	28	values	value	NOUN
admet-757	233	29	.	.	PUNCT
admet-757	234	1	however	however	ADV
admet-757	234	2	,	,	PUNCT
admet-757	234	3	the	the	DET
admet-757	234	4	absolute	absolute	ADJ
admet-757	234	5	values	value	NOUN
admet-757	234	6	were	be	AUX
admet-757	234	7	different	different	ADJ
admet-757	234	8	but	but	CCONJ
admet-757	234	9	the	the	DET
admet-757	234	10	rank	rank	NOUN
admet-757	234	11	order	order	NOUN
admet-757	234	12	for	for	ADP
admet-757	234	13	the	the	DET
admet-757	234	14	in	in	ADP
admet-757	234	15	vivo	vivo	ADJ
admet-757	234	16	distribution	distribution	NOUN
admet-757	234	17	values	value	NOUN
admet-757	234	18	remain	remain	VERB
admet-757	234	19	the	the	DET
admet-757	234	20	same	same	ADJ
admet-757	234	21	using	use	VERB
admet-757	234	22	the	the	DET
admet-757	234	23	old	old	ADJ
admet-757	234	24	and	and	CCONJ
admet-757	234	25	the	the	DET
admet-757	234	26	new	new	ADJ
admet-757	234	27	columns	column	NOUN
admet-757	234	28	.	.	PUNCT
admet-757	235	1	new	new	ADJ
admet-757	235	2	models	model	NOUN
admet-757	235	3	have	have	AUX
admet-757	235	4	also	also	ADV
admet-757	235	5	been	be	AUX
admet-757	235	6	developed	develop	VERB
admet-757	235	7	for	for	ADP
admet-757	235	8	estimating	estimate	VERB
admet-757	235	9	the	the	DET
admet-757	235	10	clinical	clinical	ADJ
admet-757	235	11	volume	volume	NOUN
admet-757	235	12	of	of	ADP
admet-757	235	13	distribution	distribution	NOUN
admet-757	235	14	of	of	ADP
admet-757	235	15	compounds	compound	NOUN
admet-757	235	16	using	use	VERB
admet-757	235	17	the	the	DET
admet-757	235	18	data	datum	NOUN
admet-757	235	19	from	from	ADP
admet-757	235	20	the	the	DET
admet-757	235	21	new	new	ADJ
admet-757	235	22	iam	iam	PROPN
admet-757	235	23	columns	column	NOUN
admet-757	235	24	.	.	PUNCT
admet-757	236	1	the	the	DET
admet-757	236	2	mathematical	mathematical	ADJ
admet-757	236	3	statistical	statistical	ADJ
admet-757	236	4	characteristics	characteristic	NOUN
admet-757	236	5	of	of	ADP
admet-757	236	6	the	the	DET
admet-757	236	7	new	new	ADJ
admet-757	236	8	models	model	NOUN
admet-757	236	9	are	be	AUX
admet-757	236	10	similar	similar	ADJ
admet-757	236	11	,	,	PUNCT
admet-757	236	12	but	but	CCONJ
admet-757	236	13	the	the	DET
admet-757	236	14	coefficients	coefficient	NOUN
admet-757	236	15	of	of	ADP
admet-757	236	16	the	the	DET
admet-757	236	17	chi	chi	NOUN
admet-757	236	18	(	(	PUNCT
admet-757	236	19	iam	iam	PROPN
admet-757	236	20	)	)	PUNCT
admet-757	236	21	and	and	CCONJ
admet-757	236	22	log	log	VERB
admet-757	236	23	k	k	PROPN
admet-757	236	24	(	(	PUNCT
admet-757	236	25	hsa	hsa	PROPN
admet-757	236	26	)	)	PUNCT
admet-757	236	27	parameters	parameter	NOUN
admet-757	236	28	are	be	AUX
admet-757	236	29	slightly	slightly	ADV
admet-757	236	30	different	different	ADJ
admet-757	236	31	.	.	PUNCT
admet-757	237	1	since	since	SCONJ
admet-757	237	2	the	the	DET
admet-757	237	3	correlation	correlation	NOUN
admet-757	237	4	between	between	ADP
admet-757	237	5	the	the	DET
admet-757	237	6	estimated	estimate	VERB
admet-757	237	7	and	and	CCONJ
admet-757	237	8	clinical	clinical	ADJ
admet-757	237	9	volume	volume	NOUN
admet-757	237	10	of	of	ADP
admet-757	237	11	distribution	distribution	NOUN
admet-757	237	12	data	datum	NOUN
admet-757	237	13	was	be	AUX
admet-757	237	14	the	the	DET
admet-757	237	15	same	same	ADJ
admet-757	237	16	or	or	CCONJ
admet-757	237	17	slightly	slightly	ADV
admet-757	237	18	better	well	ADJ
admet-757	237	19	with	with	ADP
admet-757	237	20	the	the	DET
admet-757	237	21	data	datum	NOUN
admet-757	237	22	obtained	obtain	VERB
admet-757	237	23	from	from	ADP
admet-757	237	24	the	the	DET
admet-757	237	25	new	new	ADJ
admet-757	237	26	batches	batch	NOUN
admet-757	237	27	of	of	ADP
admet-757	237	28	iam	iam	PROPN
admet-757	237	29	columns	column	NOUN
admet-757	237	30	,	,	PUNCT
admet-757	237	31	it	it	PRON
admet-757	237	32	is	be	AUX
admet-757	237	33	expected	expect	VERB
admet-757	237	34	that	that	SCONJ
admet-757	237	35	the	the	DET
admet-757	237	36	in	in	ADP
admet-757	237	37	vivo	vivo	ADJ
admet-757	237	38	estimates	estimate	NOUN
admet-757	237	39	can	can	AUX
admet-757	237	40	be	be	AUX
admet-757	237	41	as	as	ADV
admet-757	237	42	accurate	accurate	ADJ
admet-757	237	43	with	with	ADP
admet-757	237	44	the	the	DET
admet-757	237	45	data	datum	NOUN
admet-757	237	46	obtained	obtain	VERB
admet-757	237	47	from	from	ADP
admet-757	237	48	the	the	DET
admet-757	237	49	new	new	ADJ
admet-757	237	50	batches	batch	NOUN
admet-757	237	51	of	of	ADP
admet-757	237	52	iam	iam	PROPN
admet-757	237	53	columns	column	NOUN
admet-757	237	54	as	as	ADP
admet-757	237	55	with	with	ADP
admet-757	237	56	the	the	DET
admet-757	237	57	older	old	ADJ
admet-757	237	58	batches	batch	NOUN
admet-757	237	59	of	of	ADP
admet-757	237	60	iam	iam	PROPN
admet-757	237	61	columns	column	NOUN
admet-757	237	62	.	.	PUNCT
admet-757	238	1	the	the	DET
admet-757	238	2	newly	newly	ADV
admet-757	238	3	derived	derive	VERB
admet-757	238	4	equation	equation	NOUN
admet-757	238	5	(	(	PUNCT
admet-757	238	6	eqation	eqation	NOUN
admet-757	238	7	11	11	NUM
admet-757	238	8	)	)	PUNCT
admet-757	238	9	for	for	ADP
admet-757	238	10	the	the	DET
admet-757	238	11	estimation	estimation	NOUN
admet-757	238	12	of	of	ADP
admet-757	238	13	the	the	DET
admet-757	238	14	volume	volume	NOUN
admet-757	238	15	of	of	ADP
admet-757	238	16	distribution	distribution	NOUN
admet-757	238	17	is	be	AUX
admet-757	238	18	suggested	suggest	VERB
admet-757	238	19	when	when	SCONJ
admet-757	238	20	someone	someone	PRON
admet-757	238	21	begins	begin	VERB
admet-757	238	22	to	to	PART
admet-757	238	23	use	use	VERB
admet-757	238	24	biomimetic	biomimetic	ADJ
admet-757	238	25	chromatographic	chromatographic	ADJ
admet-757	238	26	measurements	measurement	NOUN
admet-757	238	27	with	with	ADP
admet-757	238	28	the	the	DET
admet-757	238	29	new	new	ADJ
admet-757	238	30	columns	column	NOUN
admet-757	238	31	.	.	PUNCT
admet-757	239	1	however	however	ADV
admet-757	239	2	,	,	PUNCT
admet-757	239	3	reference	reference	NOUN
admet-757	239	4	can	can	AUX
admet-757	239	5	still	still	ADV
admet-757	239	6	be	be	AUX
admet-757	239	7	made	make	VERB
admet-757	239	8	to	to	ADP
admet-757	239	9	the	the	DET
admet-757	239	10	existing	exist	VERB
admet-757	239	11	data	datum	NOUN
admet-757	239	12	previously	previously	ADV
admet-757	239	13	published	publish	VERB
admet-757	239	14	using	use	VERB
admet-757	239	15	the	the	DET
admet-757	239	16	older	old	ADJ
admet-757	239	17	columns	column	NOUN
admet-757	239	18	.	.	PUNCT
admet-757	240	1	conflict	conflict	NOUN
admet-757	240	2	of	of	ADP
admet-757	240	3	interest	interest	NOUN
admet-757	240	4	:	:	PUNCT
admet-757	240	5	klara	klara	PROPN
admet-757	240	6	valko	valko	PROPN
admet-757	240	7	is	be	AUX
admet-757	240	8	the	the	DET
admet-757	240	9	founder	founder	NOUN
admet-757	240	10	of	of	ADP
admet-757	240	11	bio	bio	ADJ
admet-757	240	12	-	-	ADJ
admet-757	240	13	mimetic	mimetic	ADJ
admet-757	240	14	chromatography	chromatography	PROPN
admet-757	240	15	ltd	ltd	PROPN
admet-757	240	16	.	.	PROPN
admet-757	241	1	scott	scott	PROPN
admet-757	241	2	anderson	anderson	PROPN
admet-757	241	3	is	be	AUX
admet-757	241	4	director	director	NOUN
admet-757	241	5	at	at	ADP
admet-757	241	6	regis	regis	PROPN
admet-757	241	7	technologis	technologis	PROPN
admet-757	241	8	inc	inc	PROPN
admet-757	241	9	,	,	PUNCT
admet-757	241	10	while	while	SCONJ
admet-757	241	11	shenaz	shenaz	NOUN
admet-757	241	12	bunally	bunally	ADV
admet-757	241	13	is	be	AUX
admet-757	241	14	scientist	scientist	NOUN
admet-757	241	15	at	at	ADP
admet-757	241	16	physicochemical	physicochemical	ADJ
admet-757	241	17	group	group	NOUN
admet-757	241	18	at	at	ADP
admet-757	241	19	gsk	gsk	NOUN
admet-757	241	20	.	.	PUNCT
admet-757	242	1	references	reference	NOUN
admet-757	242	2	[	[	X
admet-757	242	3	1	1	NUM
admet-757	242	4	]	]	PUNCT
admet-757	242	5	c.	c.	NOUN
admet-757	242	6	pidgeon	pidgeon	PROPN
admet-757	242	7	,	,	PUNCT
admet-757	242	8	u.v	u.v	PROPN
admet-757	242	9	.	.	PROPN
admet-757	242	10	venkataram	venkataram	PROPN
admet-757	242	11	.	.	PUNCT
admet-757	243	1	immobilized	immobilize	VERB
admet-757	243	2	artificial	artificial	ADJ
admet-757	243	3	membrane	membrane	NOUN
admet-757	243	4	chromatography	chromatography	NOUN
admet-757	243	5	:	:	PUNCT
admet-757	243	6	supports	support	VERB
admet-757	243	7	composed	compose	VERB
admet-757	243	8	of	of	ADP
admet-757	243	9	membrane	membrane	NOUN
admet-757	243	10	lipids	lipid	NOUN
admet-757	243	11	.	.	PUNCT
admet-757	244	1	anal	anal	PROPN
admet-757	244	2	.	.	PUNCT
admet-757	244	3	biochem	biochem	PROPN
admet-757	244	4	.	.	PUNCT
admet-757	245	1	176	176	NUM
admet-757	245	2	(	(	PUNCT
admet-757	245	3	1989	1989	NUM
admet-757	245	4	)	)	PUNCT
admet-757	245	5	36–47	36–47	NUM
admet-757	245	6	.	.	PUNCT
admet-757	246	1	[	[	X
admet-757	246	2	2	2	X
admet-757	246	3	]	]	PUNCT
admet-757	246	4	k.	k.	NOUN
admet-757	246	5	valkó	valkó	PROPN
admet-757	246	6	,	,	PUNCT
admet-757	246	7	p.	p.	PROPN
admet-757	246	8	slégel	slégel	PROPN
admet-757	246	9	.	.	PUNCT
admet-757	247	1	new	new	ADJ
admet-757	247	2	chromatographic	chromatographic	ADJ
admet-757	247	3	hydrophobicity	hydrophobicity	NOUN
admet-757	247	4	index	index	NOUN
admet-757	247	5	(	(	PUNCT
admet-757	247	6	φ0	φ0	PROPN
admet-757	247	7	)	)	PUNCT
admet-757	247	8	based	base	VERB
admet-757	247	9	on	on	ADP
admet-757	247	10	the	the	DET
admet-757	247	11	slope	slope	NOUN
admet-757	247	12	and	and	CCONJ
admet-757	247	13	the	the	DET
admet-757	247	14	intercept	intercept	NOUN
admet-757	247	15	of	of	ADP
admet-757	247	16	the	the	DET
admet-757	247	17	log	log	NOUN
admet-757	247	18	k′	k′	PROPN
admet-757	247	19	versus	versus	ADP
admet-757	247	20	organic	organic	ADJ
admet-757	247	21	phase	phase	NOUN
admet-757	247	22	concentration	concentration	NOUN
admet-757	247	23	plot	plot	NOUN
admet-757	247	24	.	.	PUNCT
admet-757	248	1	j.	j.	PROPN
admet-757	248	2	chromatogr	chromatogr	PROPN
admet-757	248	3	.	.	PUNCT
admet-757	249	1	a	a	PRON
admet-757	249	2	,	,	PUNCT
admet-757	249	3	631	631	NUM
admet-757	249	4	(	(	PUNCT
admet-757	249	5	1993	1993	NUM
admet-757	249	6	)	)	PUNCT
admet-757	249	7	49–61	49–61	X
admet-757	249	8	.	.	PUNCT
admet-757	250	1	[	[	X
admet-757	250	2	3	3	X
admet-757	250	3	]	]	PUNCT
admet-757	250	4	k.	k.	PROPN
admet-757	250	5	valko	valko	PROPN
admet-757	250	6	,	,	PUNCT
admet-757	250	7	c.m	c.m	PROPN
admet-757	250	8	.	.	PROPN
admet-757	250	9	du	du	PROPN
admet-757	250	10	,	,	PUNCT
admet-757	250	11	c.d	c.d	PROPN
admet-757	250	12	.	.	PROPN
admet-757	250	13	bevan	bevan	PROPN
admet-757	250	14	,	,	PUNCT
admet-757	250	15	d.p	d.p	PROPN
admet-757	250	16	.	.	PROPN
admet-757	250	17	reynolds	reynolds	PROPN
admet-757	250	18	,	,	PUNCT
admet-757	250	19	m.h	m.h	PROPN
admet-757	250	20	.	.	PROPN
admet-757	250	21	abraham	abraham	PROPN
admet-757	250	22	.	.	PUNCT
admet-757	251	1	rapid	rapid	ADJ
admet-757	251	2	-	-	PUNCT
admet-757	251	3	gradient	gradient	NOUN
admet-757	251	4	hplc	hplc	NOUN
admet-757	251	5	method	method	NOUN
admet-757	251	6	for	for	ADP
admet-757	251	7	measuring	measure	VERB
admet-757	251	8	drug	drug	NOUN
admet-757	251	9	interactions	interaction	NOUN
admet-757	251	10	with	with	ADP
admet-757	251	11	immobilized	immobilized	ADJ
admet-757	251	12	artificial	artificial	ADJ
admet-757	251	13	membrane	membrane	NOUN
admet-757	251	14	:	:	PUNCT
admet-757	251	15	comparison	comparison	NOUN
admet-757	251	16	with	with	ADP
admet-757	251	17	other	other	ADJ
admet-757	251	18	lipophilicity	lipophilicity	NOUN
admet-757	251	19	measures	measure	NOUN
admet-757	251	20	.	.	PUNCT
admet-757	252	1	j.	j.	PROPN
admet-757	252	2	pharm	pharm	PROPN
admet-757	252	3	.	.	PUNCT
admet-757	253	1	sci	sci	PROPN
admet-757	253	2	.	.	PROPN
admet-757	253	3	89	89	NUM
admet-757	253	4	(	(	PUNCT
admet-757	253	5	2000	2000	NUM
admet-757	253	6	)	)	PUNCT
admet-757	253	7	1085–1096	1085–1096	NUM
admet-757	253	8	.	.	PUNCT
admet-757	254	1	[	[	X
admet-757	254	2	4	4	NUM
admet-757	254	3	]	]	PUNCT
admet-757	254	4	k.	k.	PROPN
admet-757	254	5	valko	valko	PROPN
admet-757	254	6	,	,	PUNCT
admet-757	254	7	s.	s.	PROPN
admet-757	254	8	teague	teague	PROPN
admet-757	254	9	,	,	PUNCT
admet-757	254	10	c.	c.	PROPN
admet-757	254	11	pidgeon	pidgeon	PROPN
admet-757	254	12	.	.	PUNCT
admet-757	255	1	in	in	ADP
admet-757	255	2	vitro	vitro	X
admet-757	255	3	membrane	membrane	NOUN
admet-757	255	4	binding	bind	VERB
admet-757	255	5	and	and	CCONJ
admet-757	255	6	protein	protein	NOUN
admet-757	255	7	binding	bind	VERB
admet-757	255	8	(	(	PUNCT
admet-757	255	9	iam	iam	PROPN
admet-757	255	10	mb	mb	PROPN
admet-757	255	11	/	/	SYM
admet-757	255	12	pb	pb	X
admet-757	255	13	technology	technology	NOUN
admet-757	255	14	)	)	PUNCT
admet-757	255	15	to	to	PART
admet-757	255	16	estimate	estimate	VERB
admet-757	255	17	in	in	ADP
admet-757	255	18	vivo	vivo	ADJ
admet-757	255	19	distribution	distribution	NOUN
admet-757	255	20	:	:	PUNCT
admet-757	255	21	applications	application	NOUN
admet-757	255	22	in	in	ADP
admet-757	255	23	early	early	ADJ
admet-757	255	24	drug	drug	NOUN
admet-757	255	25	discovery	discovery	NOUN
admet-757	255	26	.	.	PUNCT
admet-757	256	1	admet	admet	PROPN
admet-757	256	2	dmpk	dmpk	PROPN
admet-757	256	3	5	5	NUM
admet-757	256	4	(	(	PUNCT
admet-757	256	5	2017	2017	NUM
admet-757	256	6	)	)	PUNCT
admet-757	256	7	14	14	NUM
admet-757	256	8	-	-	SYM
admet-757	256	9	38	38	NUM
admet-757	256	10	.	.	PUNCT
admet-757	257	1	[	[	X
admet-757	257	2	5	5	NUM
admet-757	257	3	]	]	PUNCT
admet-757	257	4	z.	z.	PROPN
admet-757	257	5	jiang	jiang	PROPN
admet-757	257	6	,	,	PUNCT
admet-757	257	7	j.	j.	PROPN
admet-757	257	8	reilly	reilly	PROPN
admet-757	257	9	.	.	PUNCT
admet-757	258	1	chromatography	chromatography	NOUN
admet-757	258	2	approaches	approach	VERB
admet-757	258	3	for	for	ADP
admet-757	258	4	early	early	ADJ
admet-757	258	5	screening	screening	NOUN
admet-757	258	6	of	of	ADP
admet-757	258	7	the	the	DET
admet-757	258	8	phospholipidosis	phospholipidosis	NOUN
admet-757	258	9	-	-	PUNCT
admet-757	258	10	inducing	induce	VERB
admet-757	258	11	potential	potential	NOUN
admet-757	258	12	of	of	ADP
admet-757	258	13	pharmaceuticals	pharmaceutical	NOUN
admet-757	258	14	.	.	PUNCT
admet-757	259	1	j.	j.	PROPN
admet-757	259	2	pharm	pharm	PROPN
admet-757	259	3	.	.	PUNCT
admet-757	259	4	biomed	biome	VERB
admet-757	259	5	.	.	PUNCT
admet-757	260	1	anal	anal	ADJ
admet-757	260	2	.	.	PUNCT
admet-757	261	1	61	61	NUM
admet-757	261	2	(	(	PUNCT
admet-757	261	3	2012	2012	NUM
admet-757	261	4	)	)	PUNCT
admet-757	262	1	184–190	184–190	NUM
admet-757	262	2	.	.	PUNCT
admet-757	263	1	[	[	X
admet-757	263	2	6	6	NUM
admet-757	263	3	]	]	X
admet-757	263	4	f.	f.	PROPN
admet-757	263	5	tsopelas	tsopelas	PROPN
admet-757	263	6	,	,	PUNCT
admet-757	263	7	c.	c.	PROPN
admet-757	263	8	giaginis	giaginis	PROPN
admet-757	263	9	,	,	PUNCT
admet-757	263	10	a.	a.	NOUN
admet-757	263	11	tsantili	tsantili	NOUN
admet-757	263	12	-	-	PUNCT
admet-757	263	13	kakoulidou	kakoulidou	NOUN
admet-757	263	14	.	.	PUNCT
admet-757	263	15	lipophilicity	lipophilicity	PROPN
admet-757	263	16	and	and	CCONJ
admet-757	263	17	biomimetic	biomimetic	ADJ
admet-757	263	18	properties	property	NOUN
admet-757	263	19	to	to	PART
admet-757	263	20	support	support	VERB
admet-757	263	21	drug	drug	NOUN
admet-757	263	22	discovery	discovery	NOUN
admet-757	263	23	.	.	PUNCT
admet-757	264	1	expert	expert	NOUN
admet-757	264	2	opin	opin	NOUN
admet-757	264	3	.	.	PUNCT
admet-757	265	1	drug	drug	NOUN
admet-757	265	2	discov	discov	NOUN
admet-757	265	3	.	.	PUNCT
admet-757	266	1	12	12	NUM
admet-757	266	2	(	(	PUNCT
admet-757	266	3	2017	2017	NUM
admet-757	266	4	)	)	PUNCT
admet-757	266	5	885–896	885–896	NUM
admet-757	266	6	.	.	PUNCT
admet-757	267	1	[	[	X
admet-757	267	2	7	7	X
admet-757	267	3	]	]	X
admet-757	267	4	f.	f.	PROPN
admet-757	267	5	tsopelas	tsopelas	PROPN
admet-757	267	6	,	,	PUNCT
admet-757	267	7	t.	t.	PROPN
admet-757	267	8	vallianatou	vallianatou	PROPN
admet-757	267	9	,	,	PUNCT
admet-757	267	10	a.	a.	NOUN
admet-757	267	11	tsantili	tsantili	NOUN
admet-757	267	12	-	-	PUNCT
admet-757	267	13	kakoulidou	kakoulidou	NOUN
admet-757	267	14	.	.	PUNCT
admet-757	267	15	advances	advance	NOUN
admet-757	267	16	in	in	ADP
admet-757	267	17	immobilized	immobilized	ADJ
admet-757	267	18	artificial	artificial	ADJ
admet-757	267	19	membrane	membrane	NOUN
admet-757	267	20	(	(	PUNCT
admet-757	267	21	iam	iam	PROPN
admet-757	267	22	)	)	PUNCT
admet-757	267	23	chromatography	chromatography	NOUN
admet-757	267	24	for	for	ADP
admet-757	267	25	novel	novel	ADJ
admet-757	267	26	drug	drug	NOUN
admet-757	267	27	discovery	discovery	NOUN
admet-757	267	28	.	.	PUNCT
admet-757	268	1	expert	expert	NOUN
admet-757	268	2	opin	opin	NOUN
admet-757	268	3	.	.	PUNCT
admet-757	269	1	drug	drug	NOUN
admet-757	269	2	discov	discov	NOUN
admet-757	269	3	.	.	PUNCT
admet-757	270	1	11	11	NUM
admet-757	270	2	(	(	PUNCT
admet-757	270	3	2016	2016	NUM
admet-757	270	4	)	)	PUNCT
admet-757	270	5	473	473	NUM
admet-757	270	6	-	-	SYM
admet-757	270	7	478	478	NUM
admet-757	270	8	.	.	PUNCT
admet-757	271	1	[	[	X
admet-757	271	2	8	8	NUM
admet-757	271	3	]	]	PUNCT
admet-757	271	4	s.	s.	PROPN
admet-757	271	5	bunally	bunally	PROPN
admet-757	271	6	,	,	PUNCT
admet-757	271	7	r.j	r.j	PROPN
admet-757	271	8	.	.	PROPN
admet-757	271	9	young	young	PROPN
admet-757	271	10	.	.	PUNCT
admet-757	272	1	the	the	DET
admet-757	272	2	role	role	NOUN
admet-757	272	3	and	and	CCONJ
admet-757	272	4	impact	impact	NOUN
admet-757	272	5	of	of	ADP
admet-757	272	6	high	high	ADJ
admet-757	272	7	throughput	throughput	NOUN
admet-757	272	8	biomimetic	biomimetic	ADJ
admet-757	272	9	measurements	measurement	NOUN
admet-757	272	10	in	in	ADP
admet-757	272	11	drug	drug	NOUN
admet-757	272	12	discovery	discovery	NOUN
admet-757	272	13	,	,	PUNCT
admet-757	272	14	admet	admet	NOUN
admet-757	272	15	and	and	CCONJ
admet-757	272	16	dmpk	dmpk	VERB
admet-757	272	17	6	6	NUM
admet-757	272	18	(	(	PUNCT
admet-757	272	19	2018	2018	NUM
admet-757	272	20	)	)	PUNCT
admet-757	272	21	74–84	74–84	PROPN
admet-757	272	22	.	.	PUNCT
admet-757	273	1	admet	admet	PROPN
admet-757	273	2	&	&	CCONJ
admet-757	273	3	dmpk	dmpk	PROPN
admet-757	273	4	8(1	8(1	NOUN
admet-757	273	5	)	)	PUNCT
admet-757	273	6	(	(	PUNCT
admet-757	273	7	2020	2020	NUM
admet-757	273	8	)	)	PUNCT
admet-757	273	9	78	78	NUM
admet-757	273	10	-	-	SYM
admet-757	273	11	97	97	NUM
admet-757	273	12	revisiting	revisit	VERB
admet-757	273	13	the	the	DET
admet-757	273	14	iam	iam	PROPN
admet-757	273	15	chromatography	chromatography	NOUN
admet-757	273	16	doi	doi	PROPN
admet-757	273	17	:	:	PUNCT
admet-757	273	18	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	273	19	97	97	NUM
admet-757	274	1	[	[	X
admet-757	274	2	9	9	NUM
admet-757	274	3	]	]	PUNCT
admet-757	274	4	a.	a.	NOUN
admet-757	274	5	taillardat	taillardat	PROPN
admet-757	274	6	-	-	PUNCT
admet-757	274	7	bertschinger	bertschinger	NOUN
admet-757	274	8	,	,	PUNCT
admet-757	274	9	c.a	c.a	PROPN
admet-757	274	10	.	.	PROPN
admet-757	274	11	martinet	martinet	PROPN
admet-757	274	12	,	,	PUNCT
admet-757	274	13	p.a	p.a	PROPN
admet-757	274	14	.	.	PROPN
admet-757	274	15	carrupt	carrupt	PROPN
admet-757	274	16	,	,	PUNCT
admet-757	274	17	m.	m.	NOUN
admet-757	274	18	reist	reist	PROPN
admet-757	274	19	,	,	PUNCT
admet-757	274	20	g.	g.	PROPN
admet-757	274	21	caron	caron	PROPN
admet-757	274	22	,	,	PUNCT
admet-757	274	23	r.	r.	PROPN
admet-757	274	24	fruttero	fruttero	PROPN
admet-757	274	25	,	,	PUNCT
admet-757	274	26	b.	b.	PROPN
admet-757	274	27	testa	testa	PROPN
admet-757	274	28	.	.	PUNCT
admet-757	275	1	molecular	molecular	ADJ
admet-757	275	2	factors	factor	NOUN
admet-757	275	3	influencing	influence	VERB
admet-757	275	4	retention	retention	NOUN
admet-757	275	5	on	on	ADP
admet-757	275	6	immobilized	immobilized	ADJ
admet-757	275	7	artifical	artifical	ADJ
admet-757	275	8	membranes	membrane	NOUN
admet-757	275	9	(	(	PUNCT
admet-757	275	10	iam	iam	PROPN
admet-757	275	11	)	)	PUNCT
admet-757	275	12	compared	compare	VERB
admet-757	275	13	to	to	ADP
admet-757	275	14	partitioning	partition	VERB
admet-757	275	15	in	in	ADP
admet-757	275	16	liposomes	liposome	NOUN
admet-757	275	17	and	and	CCONJ
admet-757	275	18	n	n	CCONJ
admet-757	275	19	-	-	PUNCT
admet-757	275	20	octanol	octanol	NOUN
admet-757	275	21	.	.	PUNCT
admet-757	276	1	pharm	pharm	NOUN
admet-757	276	2	.	.	PUNCT
admet-757	277	1	res	re	NOUN
admet-757	277	2	.	.	PROPN
admet-757	278	1	19	19	NUM
admet-757	278	2	(	(	PUNCT
admet-757	278	3	2002	2002	NUM
admet-757	278	4	)	)	PUNCT
admet-757	279	1	729–737	729–737	NUM
admet-757	279	2	.	.	PUNCT
admet-757	280	1	[	[	X
admet-757	280	2	10	10	NUM
admet-757	280	3	]	]	X
admet-757	280	4	e.	e.	PROPN
admet-757	280	5	lázaro	lázaro	PROPN
admet-757	280	6	,	,	PUNCT
admet-757	280	7	c.	c.	PROPN
admet-757	280	8	ràfols	ràfols	PROPN
admet-757	280	9	,	,	PUNCT
admet-757	280	10	m.h	m.h	PROPN
admet-757	280	11	.	.	PROPN
admet-757	280	12	abraham	abraham	PROPN
admet-757	280	13	,	,	PUNCT
admet-757	280	14	m.	m.	NOUN
admet-757	280	15	rosés	rosés	PROPN
admet-757	280	16	.	.	PUNCT
admet-757	281	1	chromatographic	chromatographic	ADJ
admet-757	281	2	estimation	estimation	NOUN
admet-757	281	3	of	of	ADP
admet-757	281	4	drug	drug	NOUN
admet-757	281	5	disposition	disposition	NOUN
admet-757	281	6	properties	property	NOUN
admet-757	281	7	by	by	ADP
admet-757	281	8	means	mean	NOUN
admet-757	281	9	of	of	ADP
admet-757	281	10	immobilized	immobilized	ADJ
admet-757	281	11	artificial	artificial	ADJ
admet-757	281	12	membranes	membrane	NOUN
admet-757	281	13	(	(	PUNCT
admet-757	281	14	iam	iam	PROPN
admet-757	281	15	)	)	PUNCT
admet-757	281	16	and	and	CCONJ
admet-757	281	17	c18	c18	NOUN
admet-757	281	18	columns	column	NOUN
admet-757	281	19	.	.	PUNCT
admet-757	282	1	j.	j.	PROPN
admet-757	282	2	med	med	PROPN
admet-757	282	3	.	.	PROPN
admet-757	282	4	chem	chem	PROPN
admet-757	282	5	.	.	PUNCT
admet-757	283	1	49	49	NUM
admet-757	283	2	(	(	PUNCT
admet-757	283	3	2006	2006	NUM
admet-757	283	4	)	)	PUNCT
admet-757	283	5	4861–4870	4861–4870	NOUN
admet-757	283	6	.	.	PUNCT
admet-757	284	1	[	[	X
admet-757	284	2	11	11	NUM
admet-757	284	3	]	]	X
admet-757	284	4	f.	f.	PROPN
admet-757	284	5	barbato	barbato	PROPN
admet-757	284	6	,	,	PUNCT
admet-757	284	7	g.	g.	PROPN
admet-757	284	8	di	di	PROPN
admet-757	284	9	martino	martino	PROPN
admet-757	284	10	,	,	PUNCT
admet-757	284	11	l.	l.	PROPN
admet-757	284	12	grumetto	grumetto	PROPN
admet-757	284	13	,	,	PUNCT
admet-757	284	14	m.i	m.i	PROPN
admet-757	284	15	.	.	PROPN
admet-757	284	16	la	la	PROPN
admet-757	284	17	rotonda	rotonda	PROPN
admet-757	284	18	.	.	PUNCT
admet-757	284	19	prediction	prediction	NOUN
admet-757	284	20	of	of	ADP
admet-757	284	21	drug	drug	NOUN
admet-757	284	22	-	-	PUNCT
admet-757	284	23	membrane	membrane	NOUN
admet-757	284	24	interactions	interaction	NOUN
admet-757	284	25	by	by	ADP
admet-757	284	26	iam	iam	PROPN
admet-757	284	27	-	-	PUNCT
admet-757	284	28	hplc	hplc	PROPN
admet-757	284	29	:	:	PUNCT
admet-757	284	30	effects	effect	NOUN
admet-757	284	31	of	of	ADP
admet-757	284	32	different	different	ADJ
admet-757	284	33	phospholipid	phospholipid	NOUN
admet-757	284	34	stationary	stationary	ADJ
admet-757	284	35	phases	phase	NOUN
admet-757	284	36	on	on	ADP
admet-757	284	37	the	the	DET
admet-757	284	38	partition	partition	NOUN
admet-757	284	39	of	of	ADP
admet-757	284	40	bases	basis	NOUN
admet-757	284	41	.	.	PUNCT
admet-757	285	1	eur	eur	PROPN
admet-757	285	2	.	.	PUNCT
admet-757	286	1	j.	j.	PROPN
admet-757	286	2	pharm	pharm	PROPN
admet-757	286	3	.	.	PUNCT
admet-757	287	1	sci	sci	PROPN
admet-757	287	2	.	.	PROPN
admet-757	288	1	22	22	NUM
admet-757	288	2	(	(	PUNCT
admet-757	288	3	2004	2004	NUM
admet-757	288	4	)	)	PUNCT
admet-757	289	1	261–269	261–269	NUM
admet-757	289	2	.	.	PUNCT
admet-757	290	1	[	[	X
admet-757	290	2	12	12	NUM
admet-757	290	3	]	]	X
admet-757	290	4	l.	l.	PROPN
admet-757	290	5	grumetto	grumetto	PROPN
admet-757	290	6	,	,	PUNCT
admet-757	290	7	g.	g.	PROPN
admet-757	290	8	russo	russo	PROPN
admet-757	290	9	,	,	PUNCT
admet-757	290	10	f.	f.	PROPN
admet-757	290	11	barbato	barbato	PROPN
admet-757	290	12	.	.	PUNCT
admet-757	291	1	immobilized	immobilize	VERB
admet-757	291	2	artificial	artificial	ADJ
admet-757	291	3	membrane	membrane	NOUN
admet-757	291	4	hplc	hplc	NOUN
admet-757	291	5	derived	derive	VERB
admet-757	291	6	parameters	parameter	NOUN
admet-757	291	7	vs	vs	ADP
admet-757	291	8	pampa	pampa	PROPN
admet-757	291	9	-	-	PUNCT
admet-757	291	10	bbb	bbb	PROPN
admet-757	291	11	data	datum	NOUN
admet-757	291	12	in	in	ADP
admet-757	291	13	estimating	estimate	VERB
admet-757	291	14	in	in	ADP
admet-757	291	15	situ	situ	ADJ
admet-757	291	16	measured	measure	VERB
admet-757	291	17	blood	blood	NOUN
admet-757	291	18	-	-	PUNCT
admet-757	291	19	brain	brain	NOUN
admet-757	291	20	barrier	barrier	NOUN
admet-757	291	21	permeation	permeation	NOUN
admet-757	291	22	of	of	ADP
admet-757	291	23	drugs	drug	NOUN
admet-757	291	24	.	.	PUNCT
admet-757	292	1	mol	mol	PROPN
admet-757	292	2	.	.	PUNCT
admet-757	292	3	pharm	pharm	PROPN
admet-757	292	4	.	.	PUNCT
admet-757	293	1	13	13	NUM
admet-757	293	2	(	(	PUNCT
admet-757	293	3	2016	2016	NUM
admet-757	293	4	)	)	PUNCT
admet-757	293	5	2808–2816	2808–2816	NUM
admet-757	293	6	.	.	PUNCT
admet-757	294	1	[	[	X
admet-757	294	2	13	13	NUM
admet-757	294	3	]	]	PUNCT
admet-757	294	4	f.	f.	PROPN
admet-757	294	5	hollosy	hollosy	PROPN
admet-757	294	6	,	,	PUNCT
admet-757	294	7	k.	k.	PROPN
admet-757	294	8	valko	valko	PROPN
admet-757	294	9	,	,	PUNCT
admet-757	294	10	a.	a.	PROPN
admet-757	294	11	hersey	hersey	PROPN
admet-757	294	12	,	,	PUNCT
admet-757	294	13	s.	s.	PROPN
admet-757	294	14	nunhuck	nunhuck	PROPN
admet-757	294	15	,	,	PUNCT
admet-757	294	16	g.	g.	PROPN
admet-757	294	17	keri	keri	PROPN
admet-757	294	18	,	,	PUNCT
admet-757	294	19	c.	c.	PROPN
admet-757	294	20	bevan	bevan	PROPN
admet-757	294	21	.	.	PUNCT
admet-757	295	1	estimation	estimation	NOUN
admet-757	295	2	of	of	ADP
admet-757	295	3	volume	volume	NOUN
admet-757	295	4	of	of	ADP
admet-757	295	5	distribution	distribution	NOUN
admet-757	295	6	in	in	ADP
admet-757	295	7	humans	human	NOUN
admet-757	295	8	from	from	ADP
admet-757	295	9	hplc	hplc	NOUN
admet-757	295	10	measurements	measurement	NOUN
admet-757	295	11	of	of	ADP
admet-757	295	12	human	human	ADJ
admet-757	295	13	serum	serum	NOUN
admet-757	295	14	albumin	albumin	NOUN
admet-757	295	15	binding	bind	VERB
admet-757	295	16	and	and	CCONJ
admet-757	295	17	immobilized	immobilize	VERB
admet-757	295	18	artificial	artificial	ADJ
admet-757	295	19	membrane	membrane	NOUN
admet-757	295	20	partitioning	partitioning	NOUN
admet-757	295	21	.	.	PUNCT
admet-757	296	1	j.	j.	PROPN
admet-757	296	2	med	med	PROPN
admet-757	296	3	.	.	PROPN
admet-757	296	4	chem	chem	PROPN
admet-757	296	5	.	.	PUNCT
admet-757	297	1	49	49	NUM
admet-757	297	2	(	(	PUNCT
admet-757	297	3	2006	2006	NUM
admet-757	297	4	)	)	PUNCT
admet-757	297	5	6958–6971	6958–6971	NUM
admet-757	297	6	.	.	PUNCT
admet-757	298	1	[	[	X
admet-757	298	2	14	14	NUM
admet-757	298	3	]	]	PUNCT
admet-757	298	4	k.	k.	PROPN
admet-757	298	5	valko	valko	PROPN
admet-757	298	6	.	.	PUNCT
admet-757	299	1	physicochemical	physicochemical	ADJ
admet-757	299	2	and	and	CCONJ
admet-757	299	3	biomimetic	biomimetic	ADJ
admet-757	299	4	properties	property	NOUN
admet-757	299	5	in	in	ADP
admet-757	299	6	drug	drug	NOUN
admet-757	299	7	discovery	discovery	NOUN
admet-757	299	8	:	:	PUNCT
admet-757	299	9	chromatographic	chromatographic	ADJ
admet-757	299	10	techniques	technique	NOUN
admet-757	299	11	for	for	ADP
admet-757	299	12	lead	lead	ADJ
admet-757	299	13	optimization	optimization	NOUN
admet-757	299	14	.	.	PUNCT
admet-757	300	1	wiley	wiley	PROPN
admet-757	300	2	hoboken	hoboken	PROPN
admet-757	300	3	nj	nj	PROPN
admet-757	300	4	,	,	PUNCT
admet-757	300	5	2014	2014	NUM
admet-757	300	6	.	.	PUNCT
admet-757	301	1	[	[	X
admet-757	301	2	15	15	NUM
admet-757	301	3	]	]	X
admet-757	301	4	f.	f.	PROPN
admet-757	301	5	tsopelas	tsopelas	PROPN
admet-757	301	6	,	,	PUNCT
admet-757	301	7	t.	t.	PROPN
admet-757	301	8	vallianatou	vallianatou	PROPN
admet-757	301	9	,	,	PUNCT
admet-757	301	10	a.	a.	NOUN
admet-757	301	11	tsantili	tsantili	NOUN
admet-757	301	12	-	-	PUNCT
admet-757	301	13	kakoulidou	kakoulidou	NOUN
admet-757	301	14	.	.	PUNCT
admet-757	302	1	the	the	DET
admet-757	302	2	potential	potential	NOUN
admet-757	302	3	of	of	ADP
admet-757	302	4	immobilized	immobilized	ADJ
admet-757	302	5	artificial	artificial	ADJ
admet-757	302	6	membrane	membrane	NOUN
admet-757	302	7	chromatography	chromatography	NOUN
admet-757	302	8	to	to	PART
admet-757	302	9	predict	predict	VERB
admet-757	302	10	human	human	ADJ
admet-757	302	11	oral	oral	ADJ
admet-757	302	12	absorption	absorption	NOUN
admet-757	302	13	.	.	PUNCT
admet-757	303	1	eur	eur	PROPN
admet-757	303	2	.	.	PUNCT
admet-757	304	1	j.	j.	PROPN
admet-757	304	2	pharm	pharm	PROPN
admet-757	304	3	.	.	PUNCT
admet-757	305	1	sci	sci	PROPN
admet-757	305	2	.	.	PROPN
admet-757	306	1	81	81	NUM
admet-757	306	2	(	(	PUNCT
admet-757	306	3	2016	2016	NUM
admet-757	306	4	)	)	PUNCT
admet-757	306	5	82–93	82–93	NUM
admet-757	306	6	.	.	PUNCT
admet-757	307	1	[	[	X
admet-757	307	2	16	16	NUM
admet-757	307	3	]	]	PUNCT
admet-757	307	4	x.	x.	PROPN
admet-757	307	5	sui	sui	PROPN
admet-757	307	6	,	,	PUNCT
admet-757	307	7	j.	j.	PROPN
admet-757	307	8	sun	sun	PROPN
admet-757	307	9	,	,	PUNCT
admet-757	307	10	h.	h.	PROPN
admet-757	307	11	li	li	PROPN
admet-757	307	12	,	,	PUNCT
admet-757	307	13	y.	y.	PROPN
admet-757	307	14	wang	wang	PROPN
admet-757	307	15	,	,	PUNCT
admet-757	307	16	j.	j.	PROPN
admet-757	307	17	liu	liu	PROPN
admet-757	307	18	,	,	PUNCT
admet-757	307	19	x.	x.	PROPN
admet-757	307	20	liu	liu	PROPN
admet-757	307	21	,	,	PUNCT
admet-757	307	22	w.	w.	PROPN
admet-757	307	23	zhang	zhang	PROPN
admet-757	307	24	,	,	PUNCT
admet-757	307	25	l.	l.	PROPN
admet-757	307	26	chen	chen	PROPN
admet-757	307	27	,	,	PUNCT
admet-757	307	28	z.he	z.he	PROPN
admet-757	307	29	.	.	PUNCT
admet-757	307	30	prediction	prediction	NOUN
admet-757	307	31	of	of	ADP
admet-757	307	32	volume	volume	NOUN
admet-757	307	33	of	of	ADP
admet-757	307	34	distribution	distribution	NOUN
admet-757	307	35	values	value	NOUN
admet-757	307	36	in	in	ADP
admet-757	307	37	human	human	ADJ
admet-757	307	38	using	use	VERB
admet-757	307	39	immobilized	immobilized	ADJ
admet-757	307	40	artificial	artificial	ADJ
admet-757	307	41	membrane	membrane	NOUN
admet-757	307	42	partitioning	partitioning	NOUN
admet-757	307	43	coefficients	coefficient	NOUN
admet-757	307	44	,	,	PUNCT
admet-757	307	45	the	the	DET
admet-757	307	46	fraction	fraction	NOUN
admet-757	307	47	of	of	ADP
admet-757	307	48	compound	compound	NOUN
admet-757	307	49	ionized	ionized	ADJ
admet-757	307	50	and	and	CCONJ
admet-757	307	51	plasma	plasma	NOUN
admet-757	307	52	protein	protein	NOUN
admet-757	307	53	binding	bind	VERB
admet-757	307	54	data	datum	NOUN
admet-757	307	55	.	.	PUNCT
admet-757	308	1	eur	eur	PROPN
admet-757	308	2	.	.	PUNCT
admet-757	309	1	j.	j.	PROPN
admet-757	309	2	med	med	PROPN
admet-757	309	3	.	.	PROPN
admet-757	309	4	chem	chem	PROPN
admet-757	309	5	.	.	PUNCT
admet-757	310	1	44	44	NUM
admet-757	310	2	(	(	PUNCT
admet-757	310	3	2009	2009	NUM
admet-757	310	4	)	)	PUNCT
admet-757	310	5	4455	4455	NUM
admet-757	310	6	–	–	PUNCT
admet-757	310	7	4460	4460	NUM
admet-757	310	8	.	.	PUNCT
admet-757	311	1	[	[	X
admet-757	311	2	17	17	NUM
admet-757	311	3	]	]	X
admet-757	311	4	k.l	k.l	PROPN
admet-757	311	5	.	.	PROPN
admet-757	311	6	valkó	valkó	PROPN
admet-757	311	7	,	,	PUNCT
admet-757	311	8	s.b	s.b	PROPN
admet-757	311	9	.	.	PROPN
admet-757	311	10	nunhuck	nunhuck	PROPN
admet-757	311	11	,	,	PUNCT
admet-757	311	12	a.p	a.p	PROPN
admet-757	311	13	.	.	PROPN
admet-757	311	14	hill	hill	PROPN
admet-757	311	15	.	.	PUNCT
admet-757	312	1	estimating	estimate	VERB
admet-757	312	2	unbound	unbound	NOUN
admet-757	312	3	volume	volume	NOUN
admet-757	312	4	of	of	ADP
admet-757	312	5	distribution	distribution	NOUN
admet-757	312	6	and	and	CCONJ
admet-757	312	7	tissue	tissue	NOUN
admet-757	312	8	binding	bind	VERB
admet-757	312	9	by	by	ADP
admet-757	312	10	in	in	ADP
admet-757	312	11	vitro	vitro	X
admet-757	312	12	hplc	hplc	NOUN
admet-757	312	13	-	-	PUNCT
admet-757	312	14	based	base	VERB
admet-757	312	15	human	human	ADJ
admet-757	312	16	serum	serum	NOUN
admet-757	312	17	albumin	albumin	NOUN
admet-757	312	18	and	and	CCONJ
admet-757	312	19	immobilized	immobilize	VERB
admet-757	312	20	artificial	artificial	ADJ
admet-757	312	21	artificial	artificial	ADJ
admet-757	312	22	membranebinding	membranebinding	NOUN
admet-757	312	23	measurements	measurement	NOUN
admet-757	312	24	.	.	PUNCT
admet-757	313	1	j.	j.	PROPN
admet-757	313	2	pharm	pharm	PROPN
admet-757	313	3	.	.	PUNCT
admet-757	314	1	sci	sci	PROPN
admet-757	314	2	.	.	PROPN
admet-757	314	3	100	100	NUM
admet-757	314	4	(	(	PUNCT
admet-757	314	5	2011	2011	NUM
admet-757	314	6	)	)	PUNCT
admet-757	314	7	849–862	849–862	NUM
admet-757	314	8	.	.	PUNCT
admet-757	315	1	[	[	X
admet-757	315	2	18	18	NUM
admet-757	315	3	]	]	PUNCT
admet-757	315	4	k.	k.	PROPN
admet-757	315	5	valko	valko	PROPN
admet-757	315	6	,	,	PUNCT
admet-757	315	7	e.	e.	PROPN
admet-757	315	8	chiarparin	chiarparin	PROPN
admet-757	315	9	,	,	PUNCT
admet-757	315	10	s.	s.	PROPN
admet-757	315	11	nunhuck	nunhuck	PROPN
admet-757	315	12	,	,	PUNCT
admet-757	315	13	d.	d.	PROPN
admet-757	315	14	montanari	montanari	PROPN
admet-757	315	15	.	.	PUNCT
admet-757	316	1	in	in	ADP
admet-757	316	2	vitro	vitro	X
admet-757	316	3	measurement	measurement	NOUN
admet-757	316	4	of	of	ADP
admet-757	316	5	drug	drug	NOUN
admet-757	316	6	efficiency	efficiency	NOUN
admet-757	316	7	index	index	NOUN
admet-757	316	8	to	to	PART
admet-757	316	9	aid	aid	VERB
admet-757	316	10	early	early	ADJ
admet-757	316	11	lead	lead	ADJ
admet-757	316	12	optimization	optimization	NOUN
admet-757	316	13	.	.	PUNCT
admet-757	317	1	j.	j.	PROPN
admet-757	317	2	pharm	pharm	PROPN
admet-757	317	3	.	.	PUNCT
admet-757	318	1	sci	sci	PROPN
admet-757	318	2	.	.	PROPN
admet-757	319	1	101	101	NUM
admet-757	319	2	(	(	PUNCT
admet-757	319	3	2012	2012	NUM
admet-757	319	4	)	)	PUNCT
admet-757	319	5	4155	4155	NUM
admet-757	319	6	-	-	SYM
admet-757	319	7	4169	4169	NUM
admet-757	319	8	.	.	PUNCT
admet-757	320	1	[	[	X
admet-757	320	2	19	19	NUM
admet-757	320	3	]	]	PUNCT
admet-757	320	4	s.	s.	PROPN
admet-757	320	5	teague	teague	PROPN
admet-757	320	6	,	,	PUNCT
admet-757	320	7	k.	k.	PROPN
admet-757	320	8	valko	valko	PROPN
admet-757	320	9	.	.	PUNCT
admet-757	321	1	how	how	SCONJ
admet-757	321	2	to	to	PART
admet-757	321	3	identify	identify	VERB
admet-757	321	4	and	and	CCONJ
admet-757	321	5	eliminate	eliminate	VERB
admet-757	321	6	compounds	compound	NOUN
admet-757	321	7	with	with	ADP
admet-757	321	8	a	a	DET
admet-757	321	9	risk	risk	NOUN
admet-757	321	10	of	of	ADP
admet-757	321	11	high	high	ADJ
admet-757	321	12	clinical	clinical	ADJ
admet-757	321	13	dose	dose	NOUN
admet-757	321	14	during	during	ADP
admet-757	321	15	the	the	DET
admet-757	321	16	early	early	ADJ
admet-757	321	17	phase	phase	NOUN
admet-757	321	18	of	of	ADP
admet-757	321	19	lead	lead	ADJ
admet-757	321	20	optimisation	optimisation	NOUN
admet-757	321	21	in	in	ADP
admet-757	321	22	drug	drug	NOUN
admet-757	321	23	discovery	discovery	NOUN
admet-757	321	24	.	.	PUNCT
admet-757	322	1	eur	eur	PROPN
admet-757	322	2	.	.	PUNCT
admet-757	323	1	j.	j.	PROPN
admet-757	323	2	pharm	pharm	PROPN
admet-757	323	3	.	.	PUNCT
admet-757	324	1	sci	sci	PROPN
admet-757	324	2	.	.	PROPN
admet-757	325	1	110	110	NUM
admet-757	325	2	(	(	PUNCT
admet-757	325	3	2017	2017	NUM
admet-757	325	4	)	)	PUNCT
admet-757	325	5	37	37	NUM
admet-757	325	6	-	-	SYM
admet-757	325	7	50	50	NUM
admet-757	325	8	.	.	PUNCT
admet-757	326	1	[	[	X
admet-757	326	2	20	20	NUM
admet-757	326	3	]	]	PUNCT
admet-757	326	4	a.	a.	NOUN
admet-757	326	5	casartelli	casartelli	PROPN
admet-757	326	6	,	,	PUNCT
admet-757	326	7	m.	m.	NOUN
admet-757	326	8	bonato	bonato	PROPN
admet-757	326	9	,	,	PUNCT
admet-757	326	10	p.	p.	PROPN
admet-757	326	11	cristofori	cristofori	PROPN
admet-757	326	12	,	,	PUNCT
admet-757	326	13	f.	f.	PROPN
admet-757	326	14	crivellente	crivellente	PROPN
admet-757	326	15	,	,	PUNCT
admet-757	326	16	g.	g.	PROPN
admet-757	326	17	dal	dal	PROPN
admet-757	326	18	negro	negro	PROPN
admet-757	326	19	,	,	PUNCT
admet-757	326	20	i.	i.	NOUN
admet-757	326	21	masotto	masotto	PROPN
admet-757	326	22	,	,	PUNCT
admet-757	326	23	c.	c.	PROPN
admet-757	326	24	mutinelli	mutinelli	PROPN
admet-757	326	25	,	,	PUNCT
admet-757	326	26	k.	k.	PROPN
admet-757	326	27	valko	valko	PROPN
admet-757	326	28	,	,	PUNCT
admet-757	326	29	v.	v.	PROPN
admet-757	326	30	bonfante	bonfante	ADJ
admet-757	326	31	.	.	PUNCT
admet-757	327	1	a	a	DET
admet-757	327	2	cell	cell	NOUN
admet-757	327	3	-	-	PUNCT
admet-757	327	4	based	base	VERB
admet-757	327	5	approach	approach	NOUN
admet-757	327	6	for	for	ADP
admet-757	327	7	the	the	DET
admet-757	327	8	early	early	ADJ
admet-757	327	9	assessment	assessment	NOUN
admet-757	327	10	of	of	ADP
admet-757	327	11	the	the	DET
admet-757	327	12	phospholipidogenic	phospholipidogenic	ADJ
admet-757	327	13	potential	potential	NOUN
admet-757	327	14	in	in	ADP
admet-757	327	15	pharmaceutical	pharmaceutical	ADJ
admet-757	327	16	research	research	NOUN
admet-757	327	17	and	and	CCONJ
admet-757	327	18	drug	drug	NOUN
admet-757	327	19	development	development	NOUN
admet-757	327	20	.	.	PUNCT
admet-757	328	1	cell	cell	NOUN
admet-757	328	2	biol	biol	PROPN
admet-757	328	3	.	.	PUNCT
admet-757	329	1	toxicol	toxicol	PROPN
admet-757	329	2	.	.	PROPN
admet-757	330	1	19	19	NUM
admet-757	330	2	(	(	PUNCT
admet-757	330	3	2003	2003	NUM
admet-757	330	4	)	)	PUNCT
admet-757	330	5	161	161	NUM
admet-757	330	6	-	-	SYM
admet-757	330	7	176	176	NUM
admet-757	330	8	.	.	PUNCT
admet-757	331	1	[	[	X
admet-757	331	2	21	21	NUM
admet-757	331	3	]	]	X
admet-757	331	4	e.	e.	PROPN
admet-757	331	5	lounkine	lounkine	PROPN
admet-757	331	6	,	,	PUNCT
admet-757	331	7	m.j	m.j	PROPN
admet-757	331	8	.	.	PROPN
admet-757	331	9	keiser	keiser	PROPN
admet-757	331	10	,	,	PUNCT
admet-757	331	11	s.	s.	PROPN
admet-757	331	12	whitebread	whitebread	PROPN
admet-757	331	13	,	,	PUNCT
admet-757	331	14	d.	d.	PROPN
admet-757	331	15	mikhailov	mikhailov	PROPN
admet-757	331	16	,	,	PUNCT
admet-757	331	17	j.	j.	PROPN
admet-757	331	18	hamon	hamon	PROPN
admet-757	331	19	,	,	PUNCT
admet-757	331	20	j.	j.	PROPN
admet-757	331	21	jenkins	jenkins	PROPN
admet-757	331	22	,	,	PUNCT
admet-757	331	23	p.	p.	PROPN
admet-757	331	24	lavan	lavan	PROPN
admet-757	331	25	,	,	PUNCT
admet-757	331	26	e.	e.	PROPN
admet-757	331	27	weber	weber	PROPN
admet-757	331	28	,	,	PUNCT
admet-757	331	29	a.k	a.k	PROPN
admet-757	331	30	.	.	PROPN
admet-757	331	31	doak	doak	PROPN
admet-757	331	32	,	,	PUNCT
admet-757	331	33	s.	s.	PROPN
admet-757	331	34	côté	côté	PROPN
admet-757	331	35	,	,	PUNCT
admet-757	331	36	b.k	b.k	PROPN
admet-757	331	37	.	.	PROPN
admet-757	331	38	shoichet	shoichet	PROPN
admet-757	331	39	,	,	PUNCT
admet-757	331	40	l.	l.	PROPN
admet-757	331	41	urban	urban	PROPN
admet-757	331	42	.	.	PUNCT
admet-757	332	1	large	large	ADJ
admet-757	332	2	scale	scale	NOUN
admet-757	332	3	prediction	prediction	NOUN
admet-757	332	4	and	and	CCONJ
admet-757	332	5	testing	testing	NOUN
admet-757	332	6	of	of	ADP
admet-757	332	7	drug	drug	NOUN
admet-757	332	8	activity	activity	NOUN
admet-757	332	9	on	on	ADP
admet-757	332	10	side	side	ADJ
admet-757	332	11	effect	effect	NOUN
admet-757	332	12	targets	target	NOUN
admet-757	332	13	,	,	PUNCT
admet-757	332	14	”	"	PUNCT
admet-757	332	15	nature	nature	NOUN
admet-757	332	16	,	,	PUNCT
admet-757	332	17	486	486	NUM
admet-757	332	18	(	(	PUNCT
admet-757	332	19	2012	2012	NUM
admet-757	332	20	)	)	PUNCT
admet-757	332	21	361–367	361–367	NUM
admet-757	332	22	.	.	PUNCT
admet-757	333	1	[	[	X
admet-757	333	2	22	22	NUM
admet-757	333	3	]	]	PUNCT
admet-757	333	4	f.	f.	PROPN
admet-757	333	5	hollosy	hollosy	PROPN
admet-757	333	6	,	,	PUNCT
admet-757	333	7	k.	k.	PROPN
admet-757	333	8	valko	valko	PROPN
admet-757	333	9	,	,	PUNCT
admet-757	333	10	a.	a.	PROPN
admet-757	333	11	hersey	hersey	PROPN
admet-757	333	12	,	,	PUNCT
admet-757	333	13	s.	s.	PROPN
admet-757	333	14	nunhuck	nunhuck	PROPN
admet-757	333	15	,	,	PUNCT
admet-757	333	16	g.	g.	PROPN
admet-757	333	17	keri	keri	PROPN
admet-757	333	18	,	,	PUNCT
admet-757	333	19	c.	c.	PROPN
admet-757	333	20	bevan	bevan	PROPN
admet-757	333	21	.	.	PUNCT
admet-757	334	1	estimation	estimation	NOUN
admet-757	334	2	of	of	ADP
admet-757	334	3	volume	volume	NOUN
admet-757	334	4	of	of	ADP
admet-757	334	5	distribution	distribution	NOUN
admet-757	334	6	in	in	ADP
admet-757	334	7	humans	human	NOUN
admet-757	334	8	from	from	ADP
admet-757	334	9	hplc	hplc	NOUN
admet-757	334	10	measurements	measurement	NOUN
admet-757	334	11	of	of	ADP
admet-757	334	12	human	human	ADJ
admet-757	334	13	serum	serum	NOUN
admet-757	334	14	albumin	albumin	NOUN
admet-757	334	15	binding	bind	VERB
admet-757	334	16	and	and	CCONJ
admet-757	334	17	immobilized	immobilize	VERB
admet-757	334	18	artificial	artificial	ADJ
admet-757	334	19	membrane	membrane	NOUN
admet-757	334	20	partitioning	partitioning	NOUN
admet-757	334	21	.	.	PUNCT
admet-757	335	1	j.	j.	PROPN
admet-757	335	2	med	med	PROPN
admet-757	335	3	.	.	PROPN
admet-757	335	4	chem	chem	PROPN
admet-757	335	5	.	.	PUNCT
admet-757	336	1	49	49	NUM
admet-757	336	2	(	(	PUNCT
admet-757	336	3	2006	2006	NUM
admet-757	336	4	)	)	PUNCT
admet-757	336	5	6958–6971	6958–6971	NUM
admet-757	336	6	.	.	PUNCT
admet-757	337	1	[	[	X
admet-757	337	2	23	23	NUM
admet-757	337	3	]	]	PUNCT
admet-757	337	4	k.	k.	PROPN
admet-757	337	5	valko	valko	PROPN
admet-757	337	6	,	,	PUNCT
admet-757	337	7	s.	s.	PROPN
admet-757	337	8	nunhuck	nunhuck	PROPN
admet-757	337	9	,	,	PUNCT
admet-757	337	10	c.	c.	PROPN
admet-757	337	11	bevan	bevan	PROPN
admet-757	337	12	,	,	PUNCT
admet-757	337	13	m.	m.	PROPN
admet-757	337	14	abraham	abraham	PROPN
admet-757	337	15	,	,	PUNCT
admet-757	337	16	d.	d.	PROPN
admet-757	337	17	reynolds	reynolds	PROPN
admet-757	337	18	.	.	PUNCT
admet-757	338	1	fast	fast	PROPN
admet-757	338	2	gradient	gradient	NOUN
admet-757	338	3	hplc	hplc	NOUN
admet-757	338	4	method	method	NOUN
admet-757	338	5	to	to	PART
admet-757	338	6	determine	determine	VERB
admet-757	338	7	compounds	compound	NOUN
admet-757	338	8	binding	bind	VERB
admet-757	338	9	to	to	ADP
admet-757	338	10	human	human	ADJ
admet-757	338	11	serum	serum	NOUN
admet-757	338	12	albumin	albumin	PROPN
admet-757	338	13	.	.	PUNCT
admet-757	339	1	relationship	relationship	NOUN
admet-757	339	2	wth	wth	PROPN
admet-757	339	3	octanol	octanol	NOUN
admet-757	339	4	water	water	NOUN
admet-757	339	5	and	and	CCONJ
admet-757	339	6	immobilized	immobilize	VERB
admet-757	339	7	artificial	artificial	ADJ
admet-757	339	8	membrane	membrane	NOUN
admet-757	339	9	lipophilicity	lipophilicity	NOUN
admet-757	339	10	.	.	PUNCT
admet-757	340	1	j.	j.	PROPN
admet-757	340	2	pharm	pharm	PROPN
admet-757	340	3	.	.	PUNCT
admet-757	341	1	sci	sci	PROPN
admet-757	341	2	.	.	PROPN
admet-757	342	1	92	92	NUM
admet-757	342	2	(	(	PUNCT
admet-757	342	3	2003	2003	NUM
admet-757	342	4	)	)	PUNCT
admet-757	342	5	2236–2248	2236–2248	NUM
admet-757	342	6	.	.	PUNCT
admet-757	343	1	©	©	PROPN
admet-757	343	2	2020	2020	NUM
admet-757	343	3	by	by	ADP
admet-757	343	4	the	the	DET
admet-757	343	5	authors	author	NOUN
admet-757	343	6	;	;	PUNCT
admet-757	343	7	licensee	licensee	PROPN
admet-757	343	8	iapc	iapc	PROPN
admet-757	343	9	,	,	PUNCT
admet-757	343	10	zagreb	zagreb	PROPN
admet-757	343	11	,	,	PUNCT
admet-757	343	12	croatia	croatia	PROPN
admet-757	343	13	.	.	PUNCT
admet-757	344	1	this	this	DET
admet-757	344	2	article	article	NOUN
admet-757	344	3	is	be	AUX
admet-757	344	4	an	an	DET
admet-757	344	5	open	open	ADJ
admet-757	344	6	-	-	PUNCT
admet-757	344	7	access	access	NOUN
admet-757	344	8	article	article	NOUN
admet-757	344	9	distributed	distribute	VERB
admet-757	344	10	under	under	ADP
admet-757	344	11	the	the	DET
admet-757	344	12	terms	term	NOUN
admet-757	344	13	and	and	CCONJ
admet-757	344	14	conditions	condition	NOUN
admet-757	344	15	of	of	ADP
admet-757	344	16	the	the	DET
admet-757	344	17	creative	creative	ADJ
admet-757	344	18	commons	common	NOUN
admet-757	344	19	attribution	attribution	NOUN
admet-757	344	20	license	license	NOUN
admet-757	344	21	(	(	PUNCT
admet-757	344	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-757	344	23	)	)	PUNCT
admet-757	344	24	http://dx.doi.org/10.5599/admet.757	http://dx.doi.org/10.5599/admet.757	VERB
admet-757	344	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN