id	sid	tid	token	lemma	pos
admet-761	1	1	optimization	optimization	NOUN
admet-761	1	2	of	of	ADP
admet-761	1	3	experimental	experimental	ADJ
admet-761	1	4	conditions	condition	NOUN
admet-761	1	5	for	for	ADP
admet-761	1	6	skin	skin	NOUN
admet-761	1	7	-	-	PUNCT
admet-761	1	8	pampa	pampa	NOUN
admet-761	1	9	measurements	measurement	NOUN
admet-761	1	10	martí	martí	PROPN
admet-761	1	11	rosés	rosé	NOUN
admet-761	2	1	et	et	PROPN
admet-761	2	2	al	al	PROPN
admet-761	2	3	.	.	PROPN
admet-761	2	4	admet	admet	PROPN
admet-761	2	5	&	&	CCONJ
admet-761	2	6	dmpk	dmpk	PROPN
admet-761	2	7	8(1	8(1	NOUN
admet-761	2	8	)	)	PUNCT
admet-761	2	9	(	(	PUNCT
admet-761	2	10	2020	2020	NUM
admet-761	2	11	)	)	PUNCT
admet-761	2	12	16	16	NUM
admet-761	2	13	-	-	SYM
admet-761	2	14	28	28	NUM
admet-761	2	15	admet	admet	PROPN
admet-761	2	16	&	&	CCONJ
admet-761	2	17	dmpk	dmpk	PROPN
admet-761	2	18	8(1	8(1	NOUN
admet-761	2	19	)	)	PUNCT
admet-761	2	20	(	(	PUNCT
admet-761	2	21	2020	2020	NUM
admet-761	2	22	)	)	PUNCT
admet-761	2	23	16	16	NUM
admet-761	2	24	-	-	SYM
admet-761	2	25	28	28	NUM
admet-761	2	26	optimization	optimization	NOUN
admet-761	2	27	of	of	ADP
admet-761	2	28	skin	skin	NOUN
admet-761	2	29	-	-	PUNCT
admet-761	2	30	pampa	pampa	NOUN
admet-761	2	31	measurements	measurement	NOUN
admet-761	2	32	admet	admet	PROPN
admet-761	2	33	&	&	CCONJ
admet-761	2	34	dmpk	dmpk	PROPN
admet-761	2	35	8(1	8(1	NOUN
admet-761	2	36	)	)	PUNCT
admet-761	2	37	(	(	PUNCT
admet-761	2	38	2020	2020	NUM
admet-761	2	39	)	)	PUNCT
admet-761	2	40	16	16	NUM
admet-761	2	41	-	-	SYM
admet-761	2	42	28	28	NUM
admet-761	2	43	;	;	PUNCT
admet-761	2	44	doi	doi	NOUN
admet-761	2	45	:	:	PUNCT
admet-761	2	46	http://dx.doi.org/10.5599/admet.761	http://dx.doi.org/10.5599/admet.761	ADJ
admet-761	2	47	open	open	ADJ
admet-761	2	48	access	access	NOUN
admet-761	2	49	:	:	PUNCT
admet-761	2	50	issn	issn	PROPN
admet-761	2	51	:	:	PUNCT
admet-761	2	52	1848	1848	NUM
admet-761	2	53	-	-	SYM
admet-761	2	54	7718	7718	NUM
admet-761	2	55	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-761	2	56	original	original	ADJ
admet-761	2	57	scientific	scientific	ADJ
admet-761	2	58	paper	paper	NOUN
admet-761	2	59	optimization	optimization	NOUN
admet-761	2	60	of	of	ADP
admet-761	2	61	experimental	experimental	ADJ
admet-761	2	62	conditions	condition	NOUN
admet-761	2	63	for	for	ADP
admet-761	2	64	skin	skin	NOUN
admet-761	2	65	-	-	PUNCT
admet-761	2	66	pampa	pampa	NOUN
admet-761	2	67	measurements	measurement	NOUN
admet-761	2	68	sara	sara	PROPN
admet-761	2	69	soriano	soriano	PROPN
admet-761	2	70	-	-	PUNCT
admet-761	2	71	meseguer1	meseguer1	PROPN
admet-761	2	72	,	,	PUNCT
admet-761	2	73	elisabet	elisabet	PROPN
admet-761	2	74	fuguet1,2	fuguet1,2	PROPN
admet-761	2	75	,	,	PUNCT
admet-761	2	76	adriana	adriana	PROPN
admet-761	2	77	port3	port3	PROPN
admet-761	2	78	,	,	PUNCT
admet-761	2	79	martí	martí	NOUN
admet-761	2	80	rosés1	rosés1	ADJ
admet-761	2	81	,	,	PUNCT
admet-761	2	82	*	*	SYM
admet-761	2	83	1	1	NUM
admet-761	2	84	departament	departament	ADJ
admet-761	2	85	de	de	PROPN
admet-761	2	86	química	química	PROPN
admet-761	2	87	analítica	analítica	PROPN
admet-761	2	88	i	i	PROPN
admet-761	2	89	institut	institut	PROPN
admet-761	2	90	de	de	PROPN
admet-761	2	91	biomedicina	biomedicina	PROPN
admet-761	2	92	,	,	PUNCT
admet-761	2	93	universitat	universitat	PROPN
admet-761	2	94	de	de	PROPN
admet-761	2	95	barcelona	barcelona	PROPN
admet-761	2	96	,	,	PUNCT
admet-761	2	97	martí	martí	NOUN
admet-761	2	98	i	i	PRON
admet-761	2	99	franquès	franquès	VERB
admet-761	2	100	1	1	NUM
admet-761	2	101	-	-	SYM
admet-761	2	102	11	11	NUM
admet-761	2	103	,	,	PUNCT
admet-761	2	104	08028	08028	NUM
admet-761	2	105	barcelona	barcelona	PROPN
admet-761	2	106	,	,	PUNCT
admet-761	2	107	spain	spain	PROPN
admet-761	2	108	2	2	NUM
admet-761	2	109	serra	serra	PROPN
admet-761	2	110	húnter	húnter	PROPN
admet-761	2	111	programme	programme	PROPN
admet-761	2	112	,	,	PUNCT
admet-761	2	113	generalitat	generalitat	PROPN
admet-761	2	114	de	de	PROPN
admet-761	2	115	catalunya	catalunya	PROPN
admet-761	2	116	,	,	PUNCT
admet-761	2	117	08002	08002	NUM
admet-761	2	118	barcelona	barcelona	PROPN
admet-761	2	119	,	,	PUNCT
admet-761	2	120	spain	spain	PROPN
admet-761	2	121	3	3	NUM
admet-761	2	122	esteve	esteve	PROPN
admet-761	2	123	pharmaceuticals	pharmaceutical	NOUN
admet-761	2	124	,	,	PUNCT
admet-761	2	125	drug	drug	NOUN
admet-761	2	126	discovery	discovery	NOUN
admet-761	2	127	and	and	CCONJ
admet-761	2	128	preclinical	preclinical	ADJ
admet-761	2	129	development	development	NOUN
admet-761	2	130	,	,	PUNCT
admet-761	2	131	parc	parc	PROPN
admet-761	2	132	científic	científic	PROPN
admet-761	2	133	de	de	PROPN
admet-761	2	134	barcelona	barcelona	PROPN
admet-761	2	135	,	,	PUNCT
admet-761	2	136	baldiri	baldiri	PROPN
admet-761	2	137	reixac	reixac	ADJ
admet-761	2	138	4	4	NUM
admet-761	2	139	-	-	SYM
admet-761	2	140	8	8	NUM
admet-761	2	141	,	,	PUNCT
admet-761	2	142	08028	08028	NUM
admet-761	2	143	barcelona	barcelona	PROPN
admet-761	2	144	,	,	PUNCT
admet-761	2	145	spain	spain	PROPN
admet-761	2	146	*	*	PUNCT
admet-761	2	147	corresponding	correspond	VERB
admet-761	2	148	author	author	NOUN
admet-761	2	149	:	:	PUNCT
admet-761	2	150	e	e	NOUN
admet-761	2	151	-	-	NOUN
admet-761	2	152	mail	mail	NOUN
admet-761	2	153	:	:	PUNCT
admet-761	2	154	marti.roses@ub.edu	marti.roses@ub.edu	NOUN
admet-761	2	155	;	;	PUNCT
admet-761	2	156	tel	tel	PROPN
admet-761	2	157	.	.	PROPN
admet-761	2	158	:	:	PUNCT
admet-761	3	1	+34	+34	ADJ
admet-761	3	2	-	-	SYM
admet-761	3	3	934039275	934039275	NUM
admet-761	3	4	;	;	PUNCT
admet-761	3	5	fax	fax	NOUN
admet-761	3	6	:	:	PUNCT
admet-761	3	7	+34	+34	ADJ
admet-761	3	8	-	-	PUNCT
admet-761	3	9	934021233	934021233	NUM
admet-761	3	10	,	,	PUNCT
admet-761	3	11	editorial	editorial	NOUN
admet-761	3	12	board	board	NOUN
admet-761	3	13	member	member	NOUN
admet-761	3	14	received	receive	VERB
admet-761	3	15	:	:	PUNCT
admet-761	3	16	november	november	PROPN
admet-761	3	17	29	29	NUM
admet-761	3	18	,	,	PUNCT
admet-761	3	19	2019	2019	NUM
admet-761	3	20	;	;	PUNCT
admet-761	3	21	revised	revise	VERB
admet-761	3	22	:	:	PUNCT
admet-761	3	23	february	february	NOUN
admet-761	3	24	15	15	NUM
admet-761	3	25	,	,	PUNCT
admet-761	3	26	2020	2020	NUM
admet-761	3	27	;	;	PUNCT
admet-761	3	28	available	available	ADJ
admet-761	3	29	online	online	ADV
admet-761	3	30	:	:	PUNCT
admet-761	3	31	march	march	PROPN
admet-761	3	32	04	04	NUM
admet-761	3	33	,	,	PUNCT
admet-761	3	34	2020	2020	NUM
admet-761	3	35	abstract	abstract	ADV
admet-761	3	36	in	in	ADP
admet-761	3	37	recent	recent	ADJ
admet-761	3	38	years	year	NOUN
admet-761	3	39	,	,	PUNCT
admet-761	3	40	the	the	DET
admet-761	3	41	parallel	parallel	ADJ
admet-761	3	42	artificial	artificial	ADJ
admet-761	3	43	membrane	membrane	NOUN
admet-761	3	44	permeability	permeability	NOUN
admet-761	3	45	assay	assay	NOUN
admet-761	3	46	(	(	PUNCT
admet-761	3	47	pampa	pampa	PROPN
admet-761	3	48	)	)	PUNCT
admet-761	3	49	has	have	AUX
admet-761	3	50	been	be	AUX
admet-761	3	51	extended	extend	VERB
admet-761	3	52	for	for	ADP
admet-761	3	53	prediction	prediction	NOUN
admet-761	3	54	of	of	ADP
admet-761	3	55	skin	skin	NOUN
admet-761	3	56	permeation	permeation	NOUN
admet-761	3	57	by	by	ADP
admet-761	3	58	developing	develop	VERB
admet-761	3	59	an	an	DET
admet-761	3	60	artificial	artificial	ADJ
admet-761	3	61	membrane	membrane	NOUN
admet-761	3	62	which	which	PRON
admet-761	3	63	mimics	mimic	VERB
admet-761	3	64	the	the	DET
admet-761	3	65	stratum	stratum	NOUN
admet-761	3	66	corneum	corneum	NOUN
admet-761	3	67	structure	structure	NOUN
admet-761	3	68	,	,	PUNCT
admet-761	3	69	skin	skin	NOUN
admet-761	3	70	-	-	PUNCT
admet-761	3	71	pampa	pampa	NOUN
admet-761	3	72	.	.	PUNCT
admet-761	4	1	in	in	ADP
admet-761	4	2	the	the	DET
admet-761	4	3	present	present	ADJ
admet-761	4	4	work	work	NOUN
admet-761	4	5	,	,	PUNCT
admet-761	4	6	the	the	DET
admet-761	4	7	different	different	ADJ
admet-761	4	8	parameters	parameter	NOUN
admet-761	4	9	affecting	affect	VERB
admet-761	4	10	skin	skin	NOUN
admet-761	4	11	-	-	PUNCT
admet-761	4	12	pampa	pampa	NOUN
admet-761	4	13	permeability	permeability	NOUN
admet-761	4	14	,	,	PUNCT
admet-761	4	15	such	such	ADJ
admet-761	4	16	as	as	ADP
admet-761	4	17	incubation	incubation	NOUN
admet-761	4	18	time	time	NOUN
admet-761	4	19	and	and	CCONJ
admet-761	4	20	stirring	stirring	NOUN
admet-761	4	21	,	,	PUNCT
admet-761	4	22	have	have	AUX
admet-761	4	23	been	be	AUX
admet-761	4	24	studied	study	VERB
admet-761	4	25	to	to	PART
admet-761	4	26	establish	establish	VERB
admet-761	4	27	ideal	ideal	ADJ
admet-761	4	28	assay	assay	NOUN
admet-761	4	29	conditions	condition	NOUN
admet-761	4	30	to	to	PART
admet-761	4	31	generate	generate	VERB
admet-761	4	32	quality	quality	NOUN
admet-761	4	33	data	datum	NOUN
admet-761	4	34	for	for	ADP
admet-761	4	35	a	a	DET
admet-761	4	36	screening	screening	NOUN
admet-761	4	37	of	of	ADP
admet-761	4	38	active	active	ADJ
admet-761	4	39	pharmaceutical	pharmaceutical	ADJ
admet-761	4	40	ingredients	ingredient	NOUN
admet-761	4	41	(	(	PUNCT
admet-761	4	42	api	api	NOUN
admet-761	4	43	)	)	PUNCT
admet-761	4	44	in	in	ADP
admet-761	4	45	early	early	ADJ
admet-761	4	46	stage	stage	NOUN
admet-761	4	47	drug	drug	NOUN
admet-761	4	48	discovery	discovery	NOUN
admet-761	4	49	.	.	PUNCT
admet-761	5	1	another	another	DET
admet-761	5	2	important	important	ADJ
admet-761	5	3	parameter	parameter	NOUN
admet-761	5	4	is	be	AUX
admet-761	5	5	membrane	membrane	ADJ
admet-761	5	6	retention	retention	NOUN
admet-761	5	7	,	,	PUNCT
admet-761	5	8	which	which	PRON
admet-761	5	9	shows	show	VERB
admet-761	5	10	dependence	dependence	NOUN
admet-761	5	11	on	on	ADP
admet-761	5	12	lipophilicity	lipophilicity	NOUN
admet-761	5	13	when	when	SCONJ
admet-761	5	14	compounds	compound	NOUN
admet-761	5	15	are	be	AUX
admet-761	5	16	in	in	ADP
admet-761	5	17	their	their	PRON
admet-761	5	18	neutral	neutral	ADJ
admet-761	5	19	form	form	NOUN
admet-761	5	20	.	.	PUNCT
admet-761	6	1	furthermore	furthermore	ADV
admet-761	6	2	,	,	PUNCT
admet-761	6	3	the	the	DET
admet-761	6	4	stability	stability	NOUN
admet-761	6	5	of	of	ADP
admet-761	6	6	the	the	DET
admet-761	6	7	membrane	membrane	NOUN
admet-761	6	8	has	have	AUX
admet-761	6	9	been	be	AUX
admet-761	6	10	investigated	investigate	VERB
admet-761	6	11	at	at	ADP
admet-761	6	12	different	different	ADJ
admet-761	6	13	ph	ph	ADJ
admet-761	6	14	values	value	NOUN
admet-761	6	15	,	,	PUNCT
admet-761	6	16	especially	especially	ADV
admet-761	6	17	at	at	ADP
admet-761	6	18	basic	basic	ADJ
admet-761	6	19	phs	phs	NOUN
admet-761	6	20	.	.	PUNCT
admet-761	7	1	finally	finally	ADV
admet-761	7	2	,	,	PUNCT
admet-761	7	3	a	a	DET
admet-761	7	4	good	good	ADJ
admet-761	7	5	correlation	correlation	NOUN
admet-761	7	6	between	between	ADP
admet-761	7	7	human	human	ADJ
admet-761	7	8	skin	skin	NOUN
admet-761	7	9	permeability	permeability	NOUN
admet-761	7	10	and	and	CCONJ
admet-761	7	11	skin	skin	NOUN
admet-761	7	12	-	-	PUNCT
admet-761	7	13	pampa	pampa	NOUN
admet-761	7	14	permeability	permeability	NOUN
admet-761	7	15	,	,	PUNCT
admet-761	7	16	with	with	ADP
admet-761	7	17	a	a	DET
admet-761	7	18	large	large	ADJ
admet-761	7	19	dataset	dataset	NOUN
admet-761	7	20	(	(	PUNCT
admet-761	7	21	n	n	NOUN
admet-761	7	22	=	=	SYM
admet-761	7	23	46	46	NUM
admet-761	7	24	)	)	PUNCT
admet-761	7	25	,	,	PUNCT
admet-761	7	26	has	have	AUX
admet-761	7	27	been	be	AUX
admet-761	7	28	established	establish	VERB
admet-761	7	29	.	.	PUNCT
admet-761	8	1	the	the	DET
admet-761	8	2	optimized	optimize	VERB
admet-761	8	3	assay	assay	NOUN
admet-761	8	4	conditions	condition	NOUN
admet-761	8	5	were	be	AUX
admet-761	8	6	an	an	DET
admet-761	8	7	incubation	incubation	NOUN
admet-761	8	8	time	time	NOUN
admet-761	8	9	of	of	ADP
admet-761	8	10	4	4	NUM
admet-761	8	11	hours	hour	NOUN
admet-761	8	12	with	with	ADP
admet-761	8	13	stirring	stir	VERB
admet-761	8	14	in	in	ADP
admet-761	8	15	a	a	DET
admet-761	8	16	ph	ph	NOUN
admet-761	8	17	below	below	ADP
admet-761	8	18	8	8	NUM
admet-761	8	19	.	.	PUNCT
admet-761	9	1	with	with	ADP
admet-761	9	2	all	all	DET
admet-761	9	3	these	these	DET
admet-761	9	4	considerations	consideration	NOUN
admet-761	9	5	the	the	DET
admet-761	9	6	thickness	thickness	NOUN
admet-761	9	7	of	of	ADP
admet-761	9	8	the	the	DET
admet-761	9	9	aqueous	aqueous	ADJ
admet-761	9	10	boundary	boundary	ADJ
admet-761	9	11	layer	layer	NOUN
admet-761	9	12	is	be	AUX
admet-761	9	13	decreased	decrease	VERB
admet-761	9	14	as	as	ADV
admet-761	9	15	much	much	ADV
admet-761	9	16	as	as	ADP
admet-761	9	17	possible	possible	ADJ
admet-761	9	18	and	and	CCONJ
admet-761	9	19	the	the	DET
admet-761	9	20	membrane	membrane	NOUN
admet-761	9	21	stability	stability	NOUN
admet-761	9	22	is	be	AUX
admet-761	9	23	guaranteed	guarantee	VERB
admet-761	9	24	.	.	PUNCT
admet-761	10	1	©	©	PROPN
admet-761	10	2	2020	2020	NUM
admet-761	10	3	by	by	ADP
admet-761	10	4	the	the	DET
admet-761	10	5	authors	author	NOUN
admet-761	10	6	.	.	PUNCT
admet-761	11	1	this	this	DET
admet-761	11	2	article	article	NOUN
admet-761	11	3	is	be	AUX
admet-761	11	4	an	an	DET
admet-761	11	5	open	open	ADJ
admet-761	11	6	-	-	PUNCT
admet-761	11	7	access	access	NOUN
admet-761	11	8	article	article	NOUN
admet-761	11	9	distributed	distribute	VERB
admet-761	11	10	under	under	ADP
admet-761	11	11	the	the	DET
admet-761	11	12	terms	term	NOUN
admet-761	11	13	and	and	CCONJ
admet-761	11	14	conditions	condition	NOUN
admet-761	11	15	of	of	ADP
admet-761	11	16	the	the	DET
admet-761	11	17	creative	creative	ADJ
admet-761	11	18	commons	common	NOUN
admet-761	11	19	attribution	attribution	NOUN
admet-761	11	20	license	license	NOUN
admet-761	11	21	(	(	PUNCT
admet-761	11	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-761	11	23	)	)	PUNCT
admet-761	11	24	.	.	PUNCT
admet-761	12	1	keywords	keyword	VERB
admet-761	12	2	skin	skin	NOUN
admet-761	12	3	-	-	PUNCT
admet-761	12	4	pampa	pampa	NOUN
admet-761	12	5	;	;	PUNCT
admet-761	12	6	permeation	permeation	NOUN
admet-761	12	7	;	;	PUNCT
admet-761	12	8	optimization	optimization	NOUN
admet-761	12	9	;	;	PUNCT
admet-761	12	10	membrane	membrane	NOUN
admet-761	12	11	retention	retention	NOUN
admet-761	12	12	;	;	PUNCT
admet-761	12	13	membrane	membrane	NOUN
admet-761	12	14	stability	stability	NOUN
admet-761	12	15	introduction	introduction	NOUN
admet-761	12	16	transdermal	transdermal	ADJ
admet-761	12	17	administration	administration	NOUN
admet-761	12	18	is	be	AUX
admet-761	12	19	considered	consider	VERB
admet-761	12	20	as	as	ADP
admet-761	12	21	an	an	DET
admet-761	12	22	alternative	alternative	ADJ
admet-761	12	23	route	route	NOUN
admet-761	12	24	to	to	ADP
admet-761	12	25	conventional	conventional	ADJ
admet-761	12	26	oral	oral	ADJ
admet-761	12	27	delivery	delivery	NOUN
admet-761	12	28	of	of	ADP
admet-761	12	29	drugs	drug	NOUN
admet-761	12	30	.	.	PUNCT
admet-761	13	1	transdermal	transdermal	ADJ
admet-761	13	2	delivery	delivery	NOUN
admet-761	13	3	offers	offer	VERB
admet-761	13	4	significant	significant	ADJ
admet-761	13	5	advantages	advantage	NOUN
admet-761	13	6	over	over	ADP
admet-761	13	7	oral	oral	ADJ
admet-761	13	8	administration	administration	NOUN
admet-761	13	9	:	:	PUNCT
admet-761	13	10	minimal	minimal	ADJ
admet-761	13	11	first	first	ADJ
admet-761	13	12	-	-	PUNCT
admet-761	13	13	pass	pass	VERB
admet-761	13	14	metabolism	metabolism	NOUN
admet-761	13	15	,	,	PUNCT
admet-761	13	16	avoidance	avoidance	NOUN
admet-761	13	17	of	of	ADP
admet-761	13	18	the	the	DET
admet-761	13	19	adverse	adverse	ADJ
admet-761	13	20	effects	effect	NOUN
admet-761	13	21	in	in	ADP
admet-761	13	22	the	the	DET
admet-761	13	23	gastrointestinal	gastrointestinal	ADJ
admet-761	13	24	environment	environment	NOUN
admet-761	13	25	and	and	CCONJ
admet-761	13	26	the	the	DET
admet-761	13	27	ability	ability	NOUN
admet-761	13	28	to	to	PART
admet-761	13	29	provide	provide	VERB
admet-761	13	30	a	a	DET
admet-761	13	31	controlled	control	VERB
admet-761	13	32	and	and	CCONJ
admet-761	13	33	prolonged	prolonged	ADJ
admet-761	13	34	drug	drug	NOUN
admet-761	13	35	release	release	NOUN
admet-761	13	36	[	[	X
admet-761	13	37	1	1	NUM
admet-761	13	38	]	]	PUNCT
admet-761	13	39	.	.	PUNCT
admet-761	14	1	despite	despite	SCONJ
admet-761	14	2	these	these	DET
admet-761	14	3	advantages	advantage	NOUN
admet-761	14	4	,	,	PUNCT
admet-761	14	5	the	the	DET
admet-761	14	6	structure	structure	NOUN
admet-761	14	7	of	of	ADP
admet-761	14	8	the	the	DET
admet-761	14	9	skin	skin	NOUN
admet-761	14	10	mainly	mainly	ADV
admet-761	14	11	composed	compose	VERB
admet-761	14	12	of	of	ADP
admet-761	14	13	the	the	DET
admet-761	14	14	stratum	stratum	NOUN
admet-761	14	15	corneum	corneum	NOUN
admet-761	14	16	(	(	PUNCT
admet-761	14	17	sc	sc	PROPN
admet-761	14	18	)	)	PUNCT
admet-761	14	19	,	,	PUNCT
admet-761	14	20	the	the	DET
admet-761	14	21	outermost	outermost	ADJ
admet-761	14	22	layer	layer	NOUN
admet-761	14	23	which	which	PRON
admet-761	14	24	acts	act	VERB
admet-761	14	25	as	as	ADP
admet-761	14	26	the	the	DET
admet-761	14	27	main	main	ADJ
admet-761	14	28	penetration	penetration	NOUN
admet-761	14	29	barrier	barrier	NOUN
admet-761	14	30	,	,	PUNCT
admet-761	14	31	the	the	DET
admet-761	14	32	viable	viable	ADJ
admet-761	14	33	epidermis	epidermis	NOUN
admet-761	14	34	and	and	CCONJ
admet-761	14	35	dermis	dermis	NOUN
admet-761	14	36	,	,	PUNCT
admet-761	14	37	imposes	impose	VERB
admet-761	14	38	a	a	DET
admet-761	14	39	clear	clear	ADJ
admet-761	14	40	obstacle	obstacle	NOUN
admet-761	14	41	to	to	ADP
admet-761	14	42	the	the	DET
admet-761	14	43	topical	topical	ADJ
admet-761	14	44	delivery	delivery	NOUN
admet-761	14	45	of	of	ADP
admet-761	14	46	drugs	drug	NOUN
admet-761	14	47	into	into	ADP
admet-761	14	48	the	the	DET
admet-761	14	49	systemic	systemic	ADJ
admet-761	14	50	bloodstream	bloodstream	NOUN
admet-761	14	51	.	.	PUNCT
admet-761	15	1	estimation	estimation	NOUN
admet-761	15	2	of	of	ADP
admet-761	15	3	skin	skin	NOUN
admet-761	15	4	permeation	permeation	NOUN
admet-761	15	5	has	have	AUX
admet-761	15	6	become	become	VERB
admet-761	15	7	crucial	crucial	ADJ
admet-761	15	8	in	in	ADP
admet-761	15	9	the	the	DET
admet-761	15	10	pharmaceutical	pharmaceutical	ADJ
admet-761	15	11	and	and	CCONJ
admet-761	15	12	cosmetic	cosmetic	NOUN
admet-761	15	13	industries	industry	NOUN
admet-761	15	14	.	.	PUNCT
admet-761	16	1	among	among	ADP
admet-761	16	2	the	the	DET
admet-761	16	3	in	in	X
admet-761	16	4	vitro	vitro	X
admet-761	16	5	models	model	NOUN
admet-761	16	6	used	use	VERB
admet-761	16	7	to	to	PART
admet-761	16	8	determine	determine	VERB
admet-761	16	9	the	the	DET
admet-761	16	10	skin	skin	NOUN
admet-761	16	11	permeation	permeation	NOUN
admet-761	16	12	,	,	PUNCT
admet-761	16	13	franz	franz	NOUN
admet-761	16	14	diffusion	diffusion	NOUN
admet-761	16	15	cell	cell	NOUN
admet-761	16	16	method	method	NOUN
admet-761	16	17	applying	apply	VERB
admet-761	16	18	human	human	ADJ
admet-761	16	19	skin	skin	NOUN
admet-761	16	20	as	as	ADP
admet-761	16	21	a	a	DET
admet-761	16	22	membrane	membrane	NOUN
admet-761	16	23	is	be	AUX
admet-761	16	24	the	the	DET
admet-761	16	25	most	most	ADV
admet-761	16	26	relevant	relevant	ADJ
admet-761	16	27	[	[	X
admet-761	16	28	2	2	NUM
admet-761	16	29	]	]	PUNCT
admet-761	16	30	,	,	PUNCT
admet-761	16	31	but	but	CCONJ
admet-761	16	32	this	this	DET
admet-761	16	33	method	method	NOUN
admet-761	16	34	is	be	AUX
admet-761	16	35	laborious	laborious	ADJ
admet-761	16	36	,	,	PUNCT
admet-761	16	37	costly	costly	ADJ
admet-761	16	38	and	and	CCONJ
admet-761	16	39	ethically	ethically	ADV
admet-761	16	40	questionable	questionable	ADJ
admet-761	16	41	.	.	PUNCT
admet-761	17	1	besides	besides	ADV
admet-761	17	2	,	,	PUNCT
admet-761	17	3	it	it	PRON
admet-761	17	4	suffers	suffer	VERB
admet-761	17	5	low	low	ADJ
admet-761	17	6	intraand	intraand	X
admet-761	17	7	inter	inter	ADJ
admet-761	17	8	-	-	ADJ
admet-761	17	9	laboratory	laboratory	ADJ
admet-761	17	10	reproducibility	reproducibility	NOUN
admet-761	17	11	.	.	PUNCT
admet-761	18	1	the	the	DET
admet-761	18	2	parallel	parallel	ADJ
admet-761	18	3	artificial	artificial	ADJ
admet-761	18	4	membrane	membrane	NOUN
admet-761	18	5	permeability	permeability	NOUN
admet-761	18	6	assay	assay	NOUN
admet-761	18	7	(	(	PUNCT
admet-761	18	8	pampa	pampa	PROPN
admet-761	18	9	)	)	PUNCT
admet-761	18	10	was	be	AUX
admet-761	18	11	developed	develop	VERB
admet-761	18	12	by	by	ADP
admet-761	18	13	kansy	kansy	PROPN
admet-761	18	14	and	and	CCONJ
admet-761	18	15	co	co	NOUN
admet-761	18	16	-	-	NOUN
admet-761	18	17	workers	worker	NOUN
admet-761	18	18	[	[	X
admet-761	18	19	3	3	X
admet-761	18	20	]	]	PUNCT
admet-761	18	21	for	for	ADP
admet-761	18	22	the	the	DET
admet-761	18	23	fast	fast	ADJ
admet-761	18	24	determination	determination	NOUN
admet-761	18	25	of	of	ADP
admet-761	18	26	the	the	DET
admet-761	18	27	permeability	permeability	NOUN
admet-761	18	28	through	through	ADP
admet-761	18	29	passive	passive	ADJ
admet-761	18	30	diffusion	diffusion	NOUN
admet-761	18	31	.	.	PUNCT
admet-761	19	1	this	this	DET
admet-761	19	2	technique	technique	NOUN
admet-761	19	3	is	be	AUX
admet-761	19	4	crucial	crucial	ADJ
admet-761	19	5	in	in	ADP
admet-761	19	6	the	the	DET
admet-761	19	7	early	early	ADJ
admet-761	19	8	stage	stage	NOUN
admet-761	19	9	of	of	ADP
admet-761	19	10	drug	drug	NOUN
admet-761	19	11	discovery	discovery	NOUN
admet-761	19	12	and	and	CCONJ
admet-761	19	13	it	it	PRON
admet-761	19	14	has	have	VERB
admet-761	19	15	many	many	ADJ
admet-761	19	16	advantages	advantage	NOUN
admet-761	19	17	like	like	ADP
admet-761	19	18	low	low	ADJ
admet-761	19	19	cost	cost	NOUN
admet-761	19	20	and	and	CCONJ
admet-761	19	21	high	high	ADJ
admet-761	19	22	-	-	PUNCT
admet-761	19	23	throughput	throughput	NOUN
admet-761	19	24	.	.	PUNCT
admet-761	20	1	the	the	DET
admet-761	20	2	first	first	ADJ
admet-761	20	3	published	publish	VERB
admet-761	20	4	models	model	NOUN
admet-761	20	5	allowed	allow	VERB
admet-761	20	6	the	the	DET
admet-761	20	7	prediction	prediction	NOUN
admet-761	20	8	of	of	ADP
admet-761	20	9	gastrointestinal	gastrointestinal	ADJ
admet-761	20	10	absorption	absorption	NOUN
admet-761	20	11	(	(	PUNCT
admet-761	20	12	git	git	NOUN
admet-761	20	13	-	-	PUNCT
admet-761	20	14	pampa	pampa	NOUN
admet-761	20	15	)	)	PUNCT
admet-761	21	1	[	[	X
admet-761	21	2	4–6	4–6	X
admet-761	21	3	]	]	X
admet-761	21	4	.	.	PUNCT
admet-761	22	1	then	then	ADV
admet-761	22	2	,	,	PUNCT
admet-761	22	3	other	other	ADJ
admet-761	22	4	models	model	NOUN
admet-761	22	5	were	be	AUX
admet-761	22	6	published	publish	VERB
admet-761	22	7	for	for	ADP
admet-761	22	8	modelling	model	VERB
admet-761	22	9	the	the	DET
admet-761	22	10	blood	blood	NOUN
admet-761	22	11	-	-	PUNCT
admet-761	22	12	brain	brain	NOUN
admet-761	22	13	barrier	barrier	NOUN
admet-761	22	14	[	[	X
admet-761	22	15	7	7	NUM
admet-761	22	16	]	]	PUNCT
admet-761	22	17	and	and	CCONJ
admet-761	22	18	also	also	ADV
admet-761	22	19	for	for	ADP
admet-761	22	20	the	the	DET
admet-761	22	21	estimation	estimation	NOUN
admet-761	22	22	of	of	ADP
admet-761	22	23	skin	skin	NOUN
admet-761	22	24	permeation	permeation	NOUN
admet-761	22	25	[	[	X
admet-761	22	26	8	8	NUM
admet-761	22	27	]	]	PUNCT
admet-761	22	28	.	.	PUNCT
admet-761	23	1	later	later	ADV
admet-761	23	2	,	,	PUNCT
admet-761	23	3	sinkó	sinkó	NOUN
admet-761	23	4	and	and	CCONJ
admet-761	23	5	co	co	NOUN
admet-761	23	6	-	-	NOUN
admet-761	23	7	workers	worker	NOUN
admet-761	23	8	developed	develop	VERB
admet-761	23	9	the	the	DET
admet-761	23	10	skin	skin	NOUN
admet-761	23	11	-	-	PUNCT
admet-761	23	12	pampa	pampa	NOUN
admet-761	23	13	methodology	methodology	NOUN
admet-761	23	14	consisting	consist	VERB
admet-761	23	15	of	of	ADP
admet-761	23	16	a	a	DET
admet-761	23	17	new	new	ADJ
admet-761	23	18	membrane	membrane	NOUN
admet-761	23	19	containing	contain	VERB
admet-761	23	20	synthetic	synthetic	ADJ
admet-761	23	21	certramides	certramide	NOUN
admet-761	23	22	,	,	PUNCT
admet-761	23	23	analogues	analogue	NOUN
admet-761	23	24	of	of	ADP
admet-761	23	25	the	the	DET
admet-761	23	26	ceramides	ceramide	NOUN
admet-761	23	27	found	find	VERB
admet-761	23	28	in	in	ADP
admet-761	23	29	the	the	DET
admet-761	23	30	stratum	stratum	NOUN
admet-761	23	31	corneum	corneum	NOUN
admet-761	23	32	[	[	X
admet-761	23	33	9,10	9,10	NUM
admet-761	23	34	]	]	PUNCT
admet-761	23	35	.	.	PUNCT
admet-761	24	1	certramides	certramide	NOUN
admet-761	24	2	are	be	AUX
admet-761	24	3	cheaper	cheap	ADJ
admet-761	24	4	alternatives	alternative	NOUN
admet-761	24	5	to	to	ADP
admet-761	24	6	natural	natural	ADJ
admet-761	24	7	ceramides	ceramide	NOUN
admet-761	24	8	with	with	ADP
admet-761	24	9	the	the	DET
admet-761	24	10	potential	potential	NOUN
admet-761	24	11	to	to	PART
admet-761	24	12	prolong	prolong	VERB
admet-761	24	13	the	the	DET
admet-761	24	14	storage	storage	NOUN
admet-761	24	15	time	time	NOUN
admet-761	24	16	.	.	PUNCT
admet-761	25	1	although	although	SCONJ
admet-761	25	2	certramides	certramide	NOUN
admet-761	25	3	are	be	AUX
admet-761	25	4	structurally	structurally	ADV
admet-761	25	5	different	different	ADJ
admet-761	25	6	from	from	ADP
admet-761	25	7	ceramides	ceramide	NOUN
admet-761	25	8	,	,	PUNCT
admet-761	25	9	their	their	PRON
admet-761	25	10	comparable	comparable	ADJ
admet-761	25	11	molecular	molecular	ADJ
admet-761	25	12	mass	mass	NOUN
admet-761	25	13	and	and	CCONJ
admet-761	25	14	hydrogen	hydrogen	NOUN
admet-761	25	15	bond	bond	NOUN
admet-761	25	16	acceptor	acceptor	NOUN
admet-761	25	17	/	/	SYM
admet-761	25	18	donor	donor	NOUN
admet-761	25	19	capacity	capacity	NOUN
admet-761	25	20	enables	enable	VERB
admet-761	25	21	them	they	PRON
admet-761	25	22	to	to	PART
admet-761	25	23	act	act	VERB
admet-761	25	24	as	as	ADP
admet-761	25	25	the	the	DET
admet-761	25	26	lipid	lipid	NOUN
admet-761	25	27	constituents	constituent	NOUN
admet-761	25	28	in	in	ADP
admet-761	25	29	the	the	DET
admet-761	25	30	pampa	pampa	NOUN
admet-761	25	31	sandwich	sandwich	NOUN
admet-761	25	32	membrane	membrane	NOUN
admet-761	25	33	,	,	PUNCT
admet-761	25	34	together	together	ADV
admet-761	25	35	with	with	ADP
admet-761	25	36	cholesterol	cholesterol	NOUN
admet-761	25	37	,	,	PUNCT
admet-761	25	38	stearic	stearic	ADJ
admet-761	25	39	acid	acid	NOUN
admet-761	25	40	and	and	CCONJ
admet-761	25	41	silicone	silicone	NOUN
admet-761	25	42	oil	oil	NOUN
admet-761	25	43	[	[	X
admet-761	25	44	9,10	9,10	NUM
admet-761	25	45	]	]	X
admet-761	25	46	.	.	PUNCT
admet-761	26	1	skin	skin	NOUN
admet-761	26	2	-	-	PUNCT
admet-761	26	3	pampa	pampa	PROPN
admet-761	26	4	is	be	AUX
admet-761	26	5	a	a	DET
admet-761	26	6	model	model	NOUN
admet-761	26	7	that	that	PRON
admet-761	26	8	offers	offer	VERB
admet-761	26	9	high	high	ADJ
admet-761	26	10	reproducibility	reproducibility	NOUN
admet-761	26	11	,	,	PUNCT
admet-761	26	12	is	be	AUX
admet-761	26	13	more	more	ADJ
admet-761	26	14	cost	cost	NOUN
admet-761	26	15	-	-	PUNCT
admet-761	26	16	effective	effective	ADJ
admet-761	26	17	and	and	CCONJ
admet-761	26	18	less	less	ADV
admet-761	26	19	laborious	laborious	ADJ
admet-761	26	20	than	than	ADP
admet-761	26	21	other	other	ADJ
admet-761	26	22	in	in	ADP
admet-761	26	23	vitro	vitro	X
admet-761	26	24	skin	skin	NOUN
admet-761	26	25	experiments	experiment	NOUN
admet-761	26	26	,	,	PUNCT
admet-761	26	27	and	and	CCONJ
admet-761	26	28	has	have	AUX
admet-761	26	29	demonstrated	demonstrate	VERB
admet-761	26	30	a	a	DET
admet-761	26	31	high	high	ADJ
admet-761	26	32	prediction	prediction	NOUN
admet-761	26	33	capability	capability	NOUN
admet-761	26	34	with	with	ADP
admet-761	26	35	a	a	DET
admet-761	26	36	good	good	ADJ
admet-761	26	37	correlation	correlation	NOUN
admet-761	26	38	with	with	ADP
admet-761	26	39	the	the	DET
admet-761	26	40	human	human	ADJ
admet-761	26	41	skin	skin	NOUN
admet-761	26	42	penetration	penetration	NOUN
admet-761	26	43	data	datum	NOUN
admet-761	26	44	[	[	X
admet-761	26	45	10	10	NUM
admet-761	26	46	]	]	PUNCT
admet-761	26	47	.	.	PUNCT
admet-761	27	1	git	git	NOUN
admet-761	27	2	pampa	pampa	PROPN
admet-761	27	3	assay	assay	VERB
admet-761	27	4	conditions	condition	NOUN
admet-761	27	5	such	such	ADJ
admet-761	27	6	as	as	ADP
admet-761	27	7	permeation	permeation	NOUN
admet-761	27	8	time	time	NOUN
admet-761	27	9	,	,	PUNCT
admet-761	27	10	assay	assay	NOUN
admet-761	27	11	ph	ph	VERB
admet-761	27	12	,	,	PUNCT
admet-761	27	13	stirring	stirring	NOUN
admet-761	27	14	,	,	PUNCT
admet-761	27	15	use	use	NOUN
admet-761	27	16	of	of	ADP
admet-761	27	17	cosolvents	cosolvent	NOUN
admet-761	27	18	and	and	CCONJ
admet-761	27	19	selection	selection	NOUN
admet-761	27	20	of	of	ADP
admet-761	27	21	detection	detection	NOUN
admet-761	27	22	techniques	technique	NOUN
admet-761	27	23	have	have	AUX
admet-761	27	24	been	be	AUX
admet-761	27	25	studied	study	VERB
admet-761	27	26	during	during	ADP
admet-761	27	27	years	year	NOUN
admet-761	27	28	and	and	CCONJ
admet-761	27	29	optimized	optimize	VERB
admet-761	27	30	to	to	PART
admet-761	27	31	generate	generate	VERB
admet-761	27	32	high	high	ADJ
admet-761	27	33	quality	quality	NOUN
admet-761	27	34	and	and	CCONJ
admet-761	27	35	relevant	relevant	ADJ
admet-761	27	36	data	datum	NOUN
admet-761	27	37	[	[	X
admet-761	27	38	5	5	NUM
admet-761	27	39	]	]	PUNCT
admet-761	27	40	.	.	PUNCT
admet-761	28	1	for	for	ADP
admet-761	28	2	skin	skin	NOUN
admet-761	28	3	-	-	PUNCT
admet-761	28	4	pampa	pampa	NOUN
admet-761	28	5	,	,	PUNCT
admet-761	28	6	only	only	ADV
admet-761	28	7	a	a	DET
admet-761	28	8	few	few	ADJ
admet-761	28	9	articles	article	NOUN
admet-761	28	10	have	have	AUX
admet-761	28	11	been	be	AUX
admet-761	28	12	published	publish	VERB
admet-761	28	13	[	[	X
admet-761	28	14	10,11	10,11	NOUN
admet-761	28	15	]	]	X
admet-761	28	16	and	and	CCONJ
admet-761	28	17	most	most	ADJ
admet-761	28	18	of	of	ADP
admet-761	28	19	them	they	PRON
admet-761	28	20	deal	deal	VERB
admet-761	28	21	with	with	ADP
admet-761	28	22	liquid	liquid	ADJ
admet-761	28	23	or	or	CCONJ
admet-761	28	24	semi	semi	ADJ
admet-761	28	25	-	-	ADJ
admet-761	28	26	solid	solid	ADJ
admet-761	28	27	formulations	formulation	NOUN
admet-761	28	28	[	[	X
admet-761	28	29	12,13	12,13	NUM
admet-761	28	30	]	]	PUNCT
admet-761	28	31	and	and	CCONJ
admet-761	28	32	transdermal	transdermal	ADJ
admet-761	28	33	patches	patch	NOUN
admet-761	28	34	[	[	X
admet-761	28	35	14	14	NUM
admet-761	28	36	]	]	PUNCT
admet-761	28	37	.	.	PUNCT
admet-761	29	1	however	however	ADV
admet-761	29	2	,	,	PUNCT
admet-761	29	3	permeability	permeability	NOUN
admet-761	29	4	studies	study	NOUN
admet-761	29	5	of	of	ADP
admet-761	29	6	compounds	compound	NOUN
admet-761	29	7	in	in	ADP
admet-761	29	8	solution	solution	NOUN
admet-761	29	9	are	be	AUX
admet-761	29	10	very	very	ADV
admet-761	29	11	important	important	ADJ
admet-761	29	12	when	when	SCONJ
admet-761	29	13	the	the	DET
admet-761	29	14	permeation	permeation	NOUN
admet-761	29	15	properties	property	NOUN
admet-761	29	16	of	of	ADP
admet-761	29	17	api	api	NOUN
admet-761	29	18	are	be	AUX
admet-761	29	19	investigated	investigate	VERB
admet-761	29	20	.	.	PUNCT
admet-761	30	1	the	the	DET
admet-761	30	2	protocol	protocol	NOUN
admet-761	30	3	of	of	ADP
admet-761	30	4	these	these	DET
admet-761	30	5	studies	study	NOUN
admet-761	30	6	depends	depend	VERB
admet-761	30	7	on	on	ADP
admet-761	30	8	the	the	DET
admet-761	30	9	physico	physico	NOUN
admet-761	30	10	-	-	PUNCT
admet-761	30	11	chemical	chemical	NOUN
admet-761	30	12	parameters	parameter	NOUN
admet-761	30	13	of	of	ADP
admet-761	30	14	the	the	DET
admet-761	30	15	api	api	NOUN
admet-761	30	16	and	and	CCONJ
admet-761	30	17	the	the	DET
admet-761	30	18	composition	composition	NOUN
admet-761	30	19	of	of	ADP
admet-761	30	20	the	the	DET
admet-761	30	21	membrane	membrane	NOUN
admet-761	30	22	.	.	PUNCT
admet-761	31	1	since	since	SCONJ
admet-761	31	2	the	the	DET
admet-761	31	3	skin	skin	NOUN
admet-761	31	4	-	-	PUNCT
admet-761	31	5	pampa	pampa	NOUN
admet-761	31	6	membrane	membrane	NOUN
admet-761	31	7	contains	contain	VERB
admet-761	31	8	different	different	ADJ
admet-761	31	9	components	component	NOUN
admet-761	31	10	and	and	CCONJ
admet-761	31	11	is	be	AUX
admet-761	31	12	more	more	ADV
admet-761	31	13	resistive	resistive	ADJ
admet-761	31	14	compared	compare	VERB
admet-761	31	15	to	to	ADP
admet-761	31	16	other	other	ADJ
admet-761	31	17	pampa	pampa	NOUN
admet-761	31	18	membranes	membrane	NOUN
admet-761	31	19	,	,	PUNCT
admet-761	31	20	protocol	protocol	NOUN
admet-761	31	21	differences	difference	NOUN
admet-761	31	22	as	as	SCONJ
admet-761	31	23	incubation	incubation	NOUN
admet-761	31	24	time	time	NOUN
admet-761	31	25	are	be	AUX
admet-761	31	26	expected	expect	VERB
admet-761	31	27	.	.	PUNCT
admet-761	32	1	the	the	DET
admet-761	32	2	reason	reason	NOUN
admet-761	32	3	for	for	ADP
admet-761	32	4	this	this	PRON
admet-761	32	5	is	be	AUX
admet-761	32	6	that	that	SCONJ
admet-761	32	7	pampa	pampa	NOUN
admet-761	32	8	membranes	membrane	NOUN
admet-761	32	9	are	be	AUX
admet-761	32	10	composed	compose	VERB
admet-761	32	11	mostly	mostly	ADV
admet-761	32	12	of	of	ADP
admet-761	32	13	lipophilic	lipophilic	ADJ
admet-761	32	14	components	component	NOUN
admet-761	32	15	and	and	CCONJ
admet-761	32	16	hence	hence	ADV
admet-761	32	17	lipophilic	lipophilic	ADJ
admet-761	32	18	compounds	compound	NOUN
admet-761	32	19	can	can	AUX
admet-761	32	20	cross	cross	VERB
admet-761	32	21	them	they	PRON
admet-761	32	22	quickly	quickly	ADV
admet-761	32	23	.	.	PUNCT
admet-761	33	1	however	however	ADV
admet-761	33	2	,	,	PUNCT
admet-761	33	3	skin	skin	NOUN
admet-761	33	4	-	-	PUNCT
admet-761	33	5	pampa	pampa	NOUN
admet-761	33	6	consists	consist	VERB
admet-761	33	7	of	of	ADP
admet-761	33	8	lipophilic	lipophilic	ADJ
admet-761	33	9	and	and	CCONJ
admet-761	33	10	hydrophilic	hydrophilic	ADJ
admet-761	33	11	moieties	moiety	NOUN
admet-761	33	12	,	,	PUNCT
admet-761	33	13	so	so	ADV
admet-761	33	14	permeable	permeable	ADJ
admet-761	33	15	compounds	compound	NOUN
admet-761	33	16	are	be	AUX
admet-761	33	17	likely	likely	ADJ
admet-761	33	18	to	to	PART
admet-761	33	19	cross	cross	VERB
admet-761	33	20	both	both	CCONJ
admet-761	33	21	lipophilic	lipophilic	ADJ
admet-761	33	22	and	and	CCONJ
admet-761	33	23	hydrophilic	hydrophilic	ADJ
admet-761	33	24	domains	domain	NOUN
admet-761	33	25	[	[	X
admet-761	33	26	10	10	NUM
admet-761	33	27	]	]	PUNCT
admet-761	33	28	.	.	PUNCT
admet-761	34	1	another	another	DET
admet-761	34	2	parameter	parameter	NOUN
admet-761	34	3	that	that	PRON
admet-761	34	4	also	also	ADV
admet-761	34	5	depends	depend	VERB
admet-761	34	6	on	on	ADP
admet-761	34	7	the	the	DET
admet-761	34	8	composition	composition	NOUN
admet-761	34	9	membrane	membrane	NOUN
admet-761	34	10	and	and	CCONJ
admet-761	34	11	physico	physico	NOUN
admet-761	34	12	-	-	PUNCT
admet-761	34	13	chemical	chemical	NOUN
admet-761	34	14	properties	property	NOUN
admet-761	34	15	of	of	ADP
admet-761	34	16	the	the	DET
admet-761	34	17	api	api	NOUN
admet-761	34	18	is	be	AUX
admet-761	34	19	the	the	DET
admet-761	34	20	unstirred	unstirred	ADJ
admet-761	34	21	water	water	NOUN
admet-761	34	22	layer	layer	NOUN
admet-761	34	23	(	(	PUNCT
admet-761	34	24	uwl	uwl	NOUN
admet-761	34	25	)	)	PUNCT
admet-761	34	26	,	,	PUNCT
admet-761	34	27	which	which	PRON
admet-761	34	28	is	be	AUX
admet-761	34	29	formed	form	VERB
admet-761	34	30	around	around	ADP
admet-761	34	31	both	both	DET
admet-761	34	32	sides	side	NOUN
admet-761	34	33	of	of	ADP
admet-761	34	34	the	the	DET
admet-761	34	35	lipophilic	lipophilic	ADJ
admet-761	34	36	membrane	membrane	NOUN
admet-761	34	37	.	.	PUNCT
admet-761	35	1	the	the	DET
admet-761	35	2	permeation	permeation	NOUN
admet-761	35	3	process	process	NOUN
admet-761	35	4	in	in	ADP
admet-761	35	5	pampa	pampa	NOUN
admet-761	35	6	assays	assay	NOUN
admet-761	35	7	may	may	AUX
admet-761	35	8	be	be	AUX
admet-761	35	9	limited	limit	VERB
admet-761	35	10	by	by	ADP
admet-761	35	11	the	the	DET
admet-761	35	12	uwl	uwl	PROPN
admet-761	35	13	,	,	PUNCT
admet-761	35	14	especially	especially	ADV
admet-761	35	15	for	for	ADP
admet-761	35	16	lipophilic	lipophilic	ADJ
admet-761	35	17	compounds	compound	NOUN
admet-761	35	18	.	.	PUNCT
admet-761	36	1	the	the	DET
admet-761	36	2	water	water	NOUN
admet-761	36	3	layer	layer	NOUN
admet-761	36	4	can	can	AUX
admet-761	36	5	act	act	VERB
admet-761	36	6	as	as	ADP
admet-761	36	7	rate	rate	NOUN
admet-761	36	8	-	-	PUNCT
admet-761	36	9	limiting	limit	VERB
admet-761	36	10	transport	transport	NOUN
admet-761	36	11	giving	give	VERB
admet-761	36	12	smaller	small	ADJ
admet-761	36	13	permeability	permeability	NOUN
admet-761	36	14	values	value	NOUN
admet-761	36	15	.	.	PUNCT
admet-761	37	1	to	to	PART
admet-761	37	2	solve	solve	VERB
admet-761	37	3	this	this	PRON
admet-761	37	4	,	,	PUNCT
admet-761	37	5	the	the	DET
admet-761	37	6	stirring	stirring	NOUN
admet-761	37	7	decreases	decrease	VERB
admet-761	37	8	the	the	DET
admet-761	37	9	uwl	uwl	NOUN
admet-761	37	10	thickness	thickness	NOUN
admet-761	37	11	and	and	CCONJ
admet-761	37	12	thus	thus	ADV
admet-761	37	13	the	the	DET
admet-761	37	14	resistance	resistance	NOUN
admet-761	37	15	of	of	ADP
admet-761	37	16	the	the	DET
admet-761	37	17	water	water	NOUN
admet-761	37	18	layer	layer	NOUN
admet-761	37	19	less	less	ADJ
admet-761	37	20	of	of	ADP
admet-761	37	21	a	a	DET
admet-761	37	22	contribution	contribution	NOUN
admet-761	37	23	to	to	ADP
admet-761	37	24	the	the	DET
admet-761	37	25	measured	measured	ADJ
admet-761	37	26	permeability	permeability	NOUN
admet-761	37	27	[	[	X
admet-761	37	28	15	15	NUM
admet-761	37	29	]	]	PUNCT
admet-761	37	30	.	.	PUNCT
admet-761	38	1	the	the	DET
admet-761	38	2	use	use	NOUN
admet-761	38	3	of	of	ADP
admet-761	38	4	the	the	DET
admet-761	38	5	oblate	oblate	ADJ
admet-761	38	6	stir	stir	NOUN
admet-761	38	7	disks	disk	NOUN
admet-761	38	8	(	(	PUNCT
admet-761	38	9	flippers	flipper	NOUN
admet-761	38	10	)	)	PUNCT
admet-761	38	11	,	,	PUNCT
admet-761	38	12	rotating	rotate	VERB
admet-761	38	13	in	in	ADP
admet-761	38	14	a	a	DET
admet-761	38	15	horizontal	horizontal	ADJ
admet-761	38	16	axis	axis	NOUN
admet-761	38	17	parallel	parallel	NOUN
admet-761	38	18	to	to	ADP
admet-761	38	19	the	the	DET
admet-761	38	20	plane	plane	NOUN
admet-761	38	21	of	of	ADP
admet-761	38	22	the	the	DET
admet-761	38	23	microtitre	microtitre	NOUN
admet-761	38	24	plates	plate	NOUN
admet-761	38	25	,	,	PUNCT
admet-761	38	26	proved	prove	VERB
admet-761	38	27	to	to	PART
admet-761	38	28	be	be	AUX
admet-761	38	29	the	the	DET
admet-761	38	30	most	most	ADV
admet-761	38	31	efficient	efficient	ADJ
admet-761	38	32	stirring	stirring	NOUN
admet-761	38	33	mechanism	mechanism	NOUN
admet-761	38	34	ever	ever	ADV
admet-761	38	35	reported	report	VERB
admet-761	38	36	in	in	ADP
admet-761	38	37	microtitre	microtitre	NOUN
admet-761	38	38	plate	plate	NOUN
admet-761	38	39	permeation	permeation	NOUN
admet-761	38	40	assays	assay	NOUN
admet-761	38	41	[	[	X
admet-761	38	42	15	15	NUM
admet-761	38	43	]	]	PUNCT
admet-761	38	44	.	.	PUNCT
admet-761	39	1	another	another	DET
admet-761	39	2	feature	feature	NOUN
admet-761	39	3	to	to	PART
admet-761	39	4	consider	consider	VERB
admet-761	39	5	is	be	AUX
admet-761	39	6	the	the	DET
admet-761	39	7	stability	stability	NOUN
admet-761	39	8	of	of	ADP
admet-761	39	9	the	the	DET
admet-761	39	10	membrane	membrane	NOUN
admet-761	39	11	.	.	PUNCT
admet-761	40	1	human	human	ADJ
admet-761	40	2	skin	skin	NOUN
admet-761	40	3	ph	ph	NOUN
admet-761	40	4	is	be	AUX
admet-761	40	5	normally	normally	ADV
admet-761	40	6	slightly	slightly	ADV
admet-761	40	7	acidic	acidic	ADJ
admet-761	40	8	,	,	PUNCT
admet-761	40	9	values	value	NOUN
admet-761	40	10	between	between	ADP
admet-761	40	11	4	4	NUM
admet-761	40	12	and	and	CCONJ
admet-761	40	13	6	6	NUM
admet-761	40	14	,	,	PUNCT
admet-761	40	15	while	while	SCONJ
admet-761	40	16	the	the	DET
admet-761	40	17	body	body	NOUN
admet-761	40	18	’s	’s	PART
admet-761	40	19	internal	internal	ADJ
admet-761	40	20	environment	environment	NOUN
admet-761	40	21	mainly	mainly	ADV
admet-761	40	22	maintains	maintain	VERB
admet-761	40	23	a	a	DET
admet-761	40	24	neutral	neutral	ADJ
admet-761	40	25	ph	ph	VERB
admet-761	40	26	.	.	PROPN
admet-761	40	27	fatty	fatty	NOUN
admet-761	40	28	acids	acid	NOUN
admet-761	40	29	found	find	VERB
admet-761	40	30	in	in	ADP
admet-761	40	31	the	the	DET
admet-761	40	32	lipid	lipid	NOUN
admet-761	40	33	bilayer	bilayer	NOUN
admet-761	40	34	exist	exist	VERB
admet-761	40	35	in	in	ADP
admet-761	40	36	the	the	DET
admet-761	40	37	neutral	neutral	ADJ
admet-761	40	38	or	or	CCONJ
admet-761	40	39	ionic	ionic	ADJ
admet-761	40	40	forms	form	NOUN
admet-761	40	41	depending	depend	VERB
admet-761	40	42	on	on	ADP
admet-761	40	43	the	the	DET
admet-761	40	44	ph	ph	NOUN
admet-761	40	45	,	,	PUNCT
admet-761	40	46	so	so	SCONJ
admet-761	40	47	they	they	PRON
admet-761	40	48	also	also	ADV
admet-761	40	49	contribute	contribute	VERB
admet-761	40	50	to	to	ADP
admet-761	40	51	the	the	DET
admet-761	40	52	ionization	ionization	NOUN
admet-761	40	53	of	of	ADP
admet-761	40	54	the	the	DET
admet-761	40	55	membrane	membrane	NOUN
admet-761	40	56	.	.	PUNCT
admet-761	41	1	at	at	ADP
admet-761	41	2	the	the	DET
admet-761	41	3	sc	sc	PROPN
admet-761	41	4	surface	surface	NOUN
admet-761	41	5	,	,	PUNCT
admet-761	41	6	ph	ph	X
admet-761	41	7	5	5	NUM
admet-761	41	8	causes	cause	VERB
admet-761	41	9	minimal	minimal	ADJ
admet-761	41	10	head‐group	head‐group	NOUN
admet-761	41	11	repulsion	repulsion	NOUN
admet-761	41	12	and	and	CCONJ
admet-761	41	13	promotes	promote	VERB
admet-761	41	14	a	a	DET
admet-761	41	15	bilayer	bilayer	NOUN
admet-761	41	16	structure	structure	NOUN
admet-761	41	17	.	.	PUNCT
admet-761	42	1	the	the	DET
admet-761	42	2	ph	ph	NOUN
admet-761	42	3	7	7	NUM
admet-761	42	4	in	in	ADP
admet-761	42	5	the	the	DET
admet-761	42	6	innermost	innermost	ADJ
admet-761	42	7	sc	sc	PROPN
admet-761	42	8	layers	layer	NOUN
admet-761	42	9	produces	produce	VERB
admet-761	42	10	90	90	NUM
admet-761	42	11	%	%	NOUN
admet-761	42	12	ionization	ionization	NOUN
admet-761	42	13	of	of	ADP
admet-761	42	14	the	the	DET
admet-761	42	15	fatty	fatty	NOUN
admet-761	42	16	acids	acid	NOUN
admet-761	42	17	leading	lead	VERB
admet-761	42	18	to	to	ADP
admet-761	42	19	head‐group	head‐group	NOUN
admet-761	42	20	repulsion	repulsion	NOUN
admet-761	42	21	.	.	PUNCT
admet-761	43	1	an	an	DET
admet-761	43	2	increase	increase	NOUN
admet-761	43	3	of	of	ADP
admet-761	43	4	the	the	DET
admet-761	43	5	ph	ph	NOUN
admet-761	43	6	leads	lead	NOUN
admet-761	43	7	to	to	PART
admet-761	43	8	increase	increase	VERB
admet-761	43	9	head‐group	head‐group	NOUN
admet-761	43	10	repulsion	repulsion	NOUN
admet-761	43	11	,	,	PUNCT
admet-761	43	12	disturbing	disturb	VERB
admet-761	43	13	epidermal	epidermal	ADJ
admet-761	43	14	lipid	lipid	NOUN
admet-761	43	15	lamella	lamella	NOUN
admet-761	43	16	and	and	CCONJ
admet-761	43	17	thus	thus	ADV
admet-761	43	18	impairing	impair	VERB
admet-761	43	19	barrier	barrier	NOUN
admet-761	43	20	function	function	NOUN
admet-761	43	21	[	[	X
admet-761	43	22	16	16	NUM
admet-761	43	23	]	]	PUNCT
admet-761	43	24	.	.	PUNCT
admet-761	44	1	as	as	SCONJ
admet-761	44	2	most	most	ADJ
admet-761	44	3	of	of	ADP
admet-761	44	4	the	the	DET
admet-761	44	5	drugs	drug	NOUN
admet-761	44	6	are	be	AUX
admet-761	44	7	weak	weak	ADJ
admet-761	44	8	acids	acid	NOUN
admet-761	44	9	or	or	CCONJ
admet-761	44	10	weak	weak	ADJ
admet-761	44	11	bases	basis	NOUN
admet-761	44	12	,	,	PUNCT
admet-761	44	13	it	it	PRON
admet-761	44	14	is	be	AUX
admet-761	44	15	relevant	relevant	ADJ
admet-761	44	16	to	to	PART
admet-761	44	17	study	study	VERB
admet-761	44	18	the	the	DET
admet-761	44	19	influence	influence	NOUN
admet-761	44	20	of	of	ADP
admet-761	44	21	the	the	DET
admet-761	44	22	ph	ph	NOUN
admet-761	44	23	on	on	ADP
admet-761	44	24	permeability	permeability	NOUN
admet-761	44	25	.	.	PUNCT
admet-761	45	1	to	to	ADP
admet-761	45	2	this	this	DET
admet-761	45	3	end	end	NOUN
admet-761	45	4	,	,	PUNCT
admet-761	45	5	it	it	PRON
admet-761	45	6	is	be	AUX
admet-761	45	7	necessary	necessary	ADJ
admet-761	45	8	to	to	PART
admet-761	45	9	study	study	VERB
admet-761	45	10	the	the	DET
admet-761	45	11	stability	stability	NOUN
admet-761	45	12	of	of	ADP
admet-761	45	13	the	the	DET
admet-761	45	14	skin	skin	NOUN
admet-761	45	15	-	-	PUNCT
admet-761	45	16	pampa	pampa	NOUN
admet-761	45	17	membrane	membrane	NOUN
admet-761	45	18	at	at	ADP
admet-761	45	19	different	different	ADJ
admet-761	45	20	ph	ph	ADJ
admet-761	45	21	values	value	NOUN
admet-761	45	22	,	,	PUNCT
admet-761	45	23	especially	especially	ADV
admet-761	45	24	at	at	ADP
admet-761	45	25	basic	basic	ADJ
admet-761	45	26	phs	phs	NOUN
admet-761	45	27	.	.	PUNCT
admet-761	46	1	in	in	ADP
admet-761	46	2	order	order	NOUN
admet-761	46	3	to	to	PART
admet-761	46	4	establish	establish	VERB
admet-761	46	5	the	the	DET
admet-761	46	6	optimal	optimal	ADJ
admet-761	46	7	assay	assay	NOUN
admet-761	46	8	conditions	condition	NOUN
admet-761	46	9	to	to	PART
admet-761	46	10	generate	generate	VERB
admet-761	46	11	quality	quality	NOUN
admet-761	46	12	data	datum	NOUN
admet-761	46	13	for	for	ADP
admet-761	46	14	the	the	DET
admet-761	46	15	screening	screening	NOUN
admet-761	46	16	of	of	ADP
admet-761	46	17	api	api	NOUN
admet-761	46	18	in	in	ADP
admet-761	46	19	early	early	ADJ
admet-761	46	20	stage	stage	NOUN
admet-761	46	21	drug	drug	NOUN
admet-761	46	22	discovery	discovery	NOUN
admet-761	46	23	,	,	PUNCT
admet-761	46	24	the	the	DET
admet-761	46	25	purposes	purpose	NOUN
admet-761	46	26	of	of	ADP
admet-761	46	27	this	this	DET
admet-761	46	28	work	work	NOUN
admet-761	46	29	are	be	AUX
admet-761	46	30	to	to	PART
admet-761	46	31	study	study	VERB
admet-761	46	32	the	the	DET
admet-761	46	33	different	different	ADJ
admet-761	46	34	parameters	parameter	NOUN
admet-761	46	35	affecting	affect	VERB
admet-761	46	36	skin	skin	NOUN
admet-761	46	37	-	-	PUNCT
admet-761	46	38	pampa	pampa	NOUN
admet-761	46	39	permeability	permeability	NOUN
admet-761	46	40	,	,	PUNCT
admet-761	46	41	such	such	ADJ
admet-761	46	42	as	as	ADP
admet-761	46	43	incubation	incubation	NOUN
admet-761	46	44	time	time	NOUN
admet-761	46	45	and	and	CCONJ
admet-761	46	46	stirring	stirring	NOUN
admet-761	46	47	,	,	PUNCT
admet-761	46	48	and	and	CCONJ
admet-761	46	49	also	also	ADV
admet-761	46	50	to	to	PART
admet-761	46	51	check	check	VERB
admet-761	46	52	the	the	DET
admet-761	46	53	stability	stability	NOUN
admet-761	46	54	of	of	ADP
admet-761	46	55	the	the	DET
admet-761	46	56	membrane	membrane	NOUN
admet-761	46	57	with	with	ADP
admet-761	46	58	ph	ph	PROPN
admet-761	46	59	.	.	PROPN
admet-761	46	60	materials	material	NOUN
admet-761	46	61	and	and	CCONJ
admet-761	46	62	methods	method	NOUN
admet-761	46	63	reagents	reagent	NOUN
admet-761	46	64	acetonitrile	acetonitrile	ADJ
admet-761	46	65	lichrosolv	lichrosolv	ADJ
admet-761	46	66	grade	grade	NOUN
admet-761	46	67	was	be	AUX
admet-761	46	68	purchased	purchase	VERB
admet-761	46	69	from	from	ADP
admet-761	46	70	merck	merck	PROPN
admet-761	46	71	(	(	PUNCT
admet-761	46	72	darmstadt	darmstadt	PROPN
admet-761	46	73	,	,	PUNCT
admet-761	46	74	germany	germany	PROPN
admet-761	46	75	)	)	PUNCT
admet-761	46	76	.	.	PUNCT
admet-761	47	1	formic	formic	PROPN
admet-761	47	2	acid	acid	PROPN
admet-761	47	3	was	be	AUX
admet-761	47	4	obtained	obtain	VERB
admet-761	47	5	from	from	ADP
admet-761	47	6	scharlau	scharlau	NOUN
admet-761	47	7	(	(	PUNCT
admet-761	47	8	sentmenat	sentmenat	NOUN
admet-761	47	9	,	,	PUNCT
admet-761	47	10	spain	spain	PROPN
admet-761	47	11	)	)	PUNCT
admet-761	47	12	.	.	PUNCT
admet-761	48	1	dimethylsulphoxide	dimethylsulphoxide	PROPN
admet-761	48	2	was	be	AUX
admet-761	48	3	from	from	ADP
admet-761	48	4	carlo	carlo	PROPN
admet-761	48	5	erba	erba	PROPN
admet-761	48	6	(	(	PUNCT
admet-761	48	7	milano	milano	PROPN
admet-761	48	8	,	,	PUNCT
admet-761	48	9	italy	italy	PROPN
admet-761	48	10	)	)	PUNCT
admet-761	48	11	.	.	PUNCT
admet-761	49	1	water	water	NOUN
admet-761	49	2	was	be	AUX
admet-761	49	3	purified	purify	VERB
admet-761	49	4	by	by	ADP
admet-761	49	5	a	a	DET
admet-761	49	6	milli	milli	ADJ
admet-761	49	7	-	-	ADJ
admet-761	49	8	q	q	ADJ
admet-761	49	9	deionizing	deionize	VERB
admet-761	49	10	system	system	NOUN
admet-761	49	11	from	from	ADP
admet-761	49	12	millipore	millipore	PROPN
admet-761	49	13	(	(	PUNCT
admet-761	49	14	billerica	billerica	PROPN
admet-761	49	15	,	,	PUNCT
admet-761	49	16	ma	ma	PROPN
admet-761	49	17	,	,	PUNCT
admet-761	49	18	usa	usa	PROPN
admet-761	49	19	)	)	PUNCT
admet-761	49	20	with	with	ADP
admet-761	49	21	a	a	DET
admet-761	49	22	resistivity	resistivity	NOUN
admet-761	49	23	of	of	ADP
admet-761	49	24	18.2	18.2	NUM
admet-761	49	25	mω	mω	NUM
admet-761	49	26	.	.	PUNCT
admet-761	50	1	most	most	ADJ
admet-761	50	2	solutes	solute	NOUN
admet-761	50	3	employed	employ	VERB
admet-761	50	4	were	be	AUX
admet-761	50	5	purchased	purchase	VERB
admet-761	50	6	from	from	ADP
admet-761	50	7	sigma	sigma	PROPN
admet-761	50	8	-	-	PUNCT
admet-761	50	9	aldrich	aldrich	PROPN
admet-761	50	10	(	(	PUNCT
admet-761	50	11	steinheim	steinheim	PROPN
admet-761	50	12	,	,	PUNCT
admet-761	50	13	germany	germany	PROPN
admet-761	50	14	)	)	PUNCT
admet-761	50	15	,	,	PUNCT
admet-761	50	16	fluka	fluka	VERB
admet-761	50	17	analytical	analytical	ADJ
admet-761	50	18	vwr	vwr	PROPN
admet-761	50	19	(	(	PUNCT
admet-761	50	20	west	west	PROPN
admet-761	50	21	chester	chester	PROPN
admet-761	50	22	,	,	PUNCT
admet-761	50	23	pa	pa	PROPN
admet-761	50	24	,	,	PUNCT
admet-761	50	25	usa	usa	PROPN
admet-761	50	26	)	)	PUNCT
admet-761	50	27	,	,	PUNCT
admet-761	50	28	riedel	riedel	NOUN
admet-761	50	29	-	-	PUNCT
admet-761	50	30	de	de	X
admet-761	50	31	haën	haën	PROPN
admet-761	50	32	(	(	PUNCT
admet-761	50	33	seelze	seelze	PROPN
admet-761	50	34	,	,	PUNCT
admet-761	50	35	germany	germany	PROPN
admet-761	50	36	)	)	PUNCT
admet-761	50	37	,	,	PUNCT
admet-761	50	38	merck	merck	PROPN
admet-761	50	39	(	(	PUNCT
admet-761	50	40	darmstadt	darmstadt	PROPN
admet-761	50	41	,	,	PUNCT
admet-761	50	42	germany	germany	PROPN
admet-761	50	43	)	)	PUNCT
admet-761	50	44	,	,	PUNCT
admet-761	50	45	carlo	carlo	PROPN
admet-761	50	46	erba	erba	PROPN
admet-761	50	47	(	(	PUNCT
admet-761	50	48	milano	milano	PROPN
admet-761	50	49	,	,	PUNCT
admet-761	50	50	italy	italy	PROPN
admet-761	50	51	)	)	PUNCT
admet-761	50	52	and	and	CCONJ
admet-761	50	53	baker	baker	PROPN
admet-761	50	54	(	(	PUNCT
admet-761	50	55	center	center	PROPN
admet-761	50	56	valley	valley	NOUN
admet-761	50	57	,	,	PUNCT
admet-761	50	58	pa	pa	PROPN
admet-761	50	59	,	,	PUNCT
admet-761	50	60	usa	usa	PROPN
admet-761	50	61	)	)	PUNCT
admet-761	50	62	.	.	PUNCT
admet-761	51	1	some	some	DET
admet-761	51	2	drugs	drug	NOUN
admet-761	51	3	were	be	AUX
admet-761	51	4	synthesized	synthesize	VERB
admet-761	51	5	in	in	ADP
admet-761	51	6	esteve	esteve	PROPN
admet-761	51	7	(	(	PUNCT
admet-761	51	8	barcelona	barcelona	PROPN
admet-761	51	9	,	,	PUNCT
admet-761	51	10	spain	spain	PROPN
admet-761	51	11	)	)	PUNCT
admet-761	51	12	.	.	PUNCT
admet-761	52	1	the	the	DET
admet-761	52	2	concentrated	concentrate	VERB
admet-761	52	3	prisma	prisma	PROPN
admet-761	52	4	httm	httm	NOUN
admet-761	52	5	solution	solution	NOUN
admet-761	52	6	was	be	AUX
admet-761	52	7	used	use	VERB
admet-761	52	8	to	to	PART
admet-761	52	9	prepare	prepare	VERB
admet-761	52	10	the	the	DET
admet-761	52	11	buffer	buffer	NOUN
admet-761	52	12	solutions	solution	NOUN
admet-761	52	13	.	.	PUNCT
admet-761	53	1	this	this	DET
admet-761	53	2	solution	solution	NOUN
admet-761	53	3	is	be	AUX
admet-761	53	4	a	a	DET
admet-761	53	5	universal	universal	ADJ
admet-761	53	6	buffer	buffer	NOUN
admet-761	53	7	designed	design	VERB
admet-761	53	8	by	by	ADP
admet-761	53	9	pion	pion	PROPN
admet-761	53	10	inc	inc	PROPN
admet-761	53	11	(	(	PUNCT
admet-761	53	12	billerica	billerica	PROPN
admet-761	53	13	,	,	PUNCT
admet-761	53	14	ma	ma	PROPN
admet-761	53	15	,	,	PUNCT
admet-761	53	16	usa	usa	PROPN
admet-761	53	17	)	)	PUNCT
admet-761	53	18	and	and	CCONJ
admet-761	53	19	is	be	AUX
admet-761	53	20	formed	form	VERB
admet-761	53	21	by	by	ADP
admet-761	53	22	several	several	ADJ
admet-761	53	23	compounds	compound	NOUN
admet-761	53	24	with	with	ADP
admet-761	53	25	pka	pka	PROPN
admet-761	53	26	values	value	NOUN
admet-761	53	27	evenly	evenly	ADV
admet-761	53	28	spaced	space	VERB
admet-761	53	29	to	to	PART
admet-761	53	30	produce	produce	VERB
admet-761	53	31	a	a	DET
admet-761	53	32	constant	constant	ADJ
admet-761	53	33	buffer	buffer	NOUN
admet-761	53	34	capacity	capacity	NOUN
admet-761	53	35	in	in	ADP
admet-761	53	36	the	the	DET
admet-761	53	37	range	range	NOUN
admet-761	53	38	ph	ph	VERB
admet-761	53	39	3	3	NUM
admet-761	53	40	-	-	SYM
admet-761	53	41	10	10	NUM
admet-761	53	42	.	.	PUNCT
admet-761	54	1	the	the	DET
admet-761	54	2	ionic	ionic	ADJ
admet-761	54	3	strength	strength	NOUN
admet-761	54	4	of	of	ADP
admet-761	54	5	the	the	DET
admet-761	54	6	prisma	prisma	NOUN
admet-761	54	7	httm	httm	NOUN
admet-761	54	8	is	be	AUX
admet-761	54	9	about	about	ADV
admet-761	54	10	10	10	NUM
admet-761	54	11	mm	mm	NOUN
admet-761	54	12	.	.	PUNCT
admet-761	55	1	a	a	DET
admet-761	55	2	hydration	hydration	NOUN
admet-761	55	3	solution	solution	NOUN
admet-761	55	4	from	from	ADP
admet-761	55	5	pion	pion	PROPN
admet-761	55	6	inc	inc	PROPN
admet-761	55	7	.	.	PROPN
admet-761	55	8	(	(	PUNCT
admet-761	55	9	billerica	billerica	PROPN
admet-761	55	10	,	,	PUNCT
admet-761	55	11	ma	ma	PROPN
admet-761	55	12	,	,	PUNCT
admet-761	55	13	usa	usa	PROPN
admet-761	55	14	)	)	PUNCT
admet-761	55	15	was	be	AUX
admet-761	55	16	used	use	VERB
admet-761	55	17	to	to	PART
admet-761	55	18	rehydrate	rehydrate	VERB
admet-761	55	19	the	the	DET
admet-761	55	20	artificial	artificial	ADJ
admet-761	55	21	skin	skin	NOUN
admet-761	55	22	membrane	membrane	NOUN
admet-761	55	23	.	.	PUNCT
admet-761	56	1	the	the	DET
admet-761	56	2	skin	skin	NOUN
admet-761	56	3	-	-	PUNCT
admet-761	56	4	pampa	pampa	NOUN
admet-761	56	5	plates	plate	NOUN
admet-761	56	6	,	,	PUNCT
admet-761	56	7	with	with	ADP
admet-761	56	8	a	a	DET
admet-761	56	9	membrane	membrane	NOUN
admet-761	56	10	composed	compose	VERB
admet-761	56	11	by	by	ADP
admet-761	56	12	certramides	certramide	NOUN
admet-761	56	13	,	,	PUNCT
admet-761	56	14	cholesterol	cholesterol	NOUN
admet-761	56	15	,	,	PUNCT
admet-761	56	16	stearic	stearic	ADJ
admet-761	56	17	acid	acid	NOUN
admet-761	56	18	,	,	PUNCT
admet-761	56	19	and	and	CCONJ
admet-761	56	20	silicone	silicone	NOUN
admet-761	56	21	oil	oil	NOUN
admet-761	56	22	,	,	PUNCT
admet-761	56	23	were	be	AUX
admet-761	56	24	also	also	ADV
admet-761	56	25	obtained	obtain	VERB
admet-761	56	26	from	from	ADP
admet-761	56	27	pion	pion	PROPN
admet-761	56	28	inc	inc	PROPN
admet-761	56	29	.	.	PROPN
admet-761	57	1	(	(	PUNCT
admet-761	57	2	billerica	billerica	PROPN
admet-761	57	3	,	,	PUNCT
admet-761	57	4	ma	ma	PROPN
admet-761	57	5	,	,	PUNCT
admet-761	57	6	usa	usa	PROPN
admet-761	57	7	)	)	PUNCT
admet-761	57	8	.	.	PUNCT
admet-761	58	1	instruments	instrument	NOUN
admet-761	58	2	ph	ph	ADJ
admet-761	58	3	measurements	measurement	NOUN
admet-761	58	4	were	be	AUX
admet-761	58	5	done	do	VERB
admet-761	58	6	with	with	ADP
admet-761	58	7	a	a	DET
admet-761	58	8	combined	combined	ADJ
admet-761	58	9	crison	crison	NOUN
admet-761	58	10	5202	5202	NUM
admet-761	58	11	electrode	electrode	NOUN
admet-761	58	12	in	in	ADP
admet-761	58	13	a	a	DET
admet-761	58	14	crison	crison	NOUN
admet-761	58	15	2001	2001	NUM
admet-761	58	16	ph	ph	NOUN
admet-761	58	17	meter	meter	NOUN
admet-761	58	18	(	(	PUNCT
admet-761	58	19	hach	hach	NOUN
admet-761	58	20	lange	lange	PROPN
admet-761	58	21	spain	spain	PROPN
admet-761	58	22	,	,	PUNCT
admet-761	58	23	l’hospitalet	l’hospitalet	PROPN
admet-761	58	24	de	de	X
admet-761	58	25	llobregat	llobregat	PROPN
admet-761	58	26	,	,	PUNCT
admet-761	58	27	spain	spain	PROPN
admet-761	58	28	)	)	PUNCT
admet-761	58	29	.	.	PUNCT
admet-761	59	1	the	the	DET
admet-761	59	2	electrode	electrode	NOUN
admet-761	59	3	system	system	NOUN
admet-761	59	4	was	be	AUX
admet-761	59	5	calibrated	calibrate	VERB
admet-761	59	6	with	with	ADP
admet-761	59	7	the	the	DET
admet-761	59	8	ordinary	ordinary	ADJ
admet-761	59	9	aqueous	aqueous	ADJ
admet-761	59	10	buffers	buffer	NOUN
admet-761	59	11	of	of	ADP
admet-761	59	12	ph	ph	PROPN
admet-761	59	13	4.01	4.01	NUM
admet-761	59	14	and	and	CCONJ
admet-761	59	15	7.00	7.00	NUM
admet-761	59	16	(	(	PUNCT
admet-761	59	17	25	25	NUM
admet-761	59	18	°	°	NOUN
admet-761	59	19	c	c	NOUN
admet-761	59	20	)	)	PUNCT
admet-761	59	21	.	.	PUNCT
admet-761	60	1	permeability	permeability	NOUN
admet-761	60	2	measurements	measurement	NOUN
admet-761	60	3	were	be	AUX
admet-761	60	4	made	make	VERB
admet-761	60	5	with	with	ADP
admet-761	60	6	the	the	DET
admet-761	60	7	pampa	pampa	NOUN
admet-761	60	8	explorer	explorer	NOUN
admet-761	60	9	permeability	permeability	PROPN
admet-761	60	10	assay	assay	NOUN
admet-761	60	11	instrument	instrument	NOUN
admet-761	60	12	from	from	ADP
admet-761	60	13	pion	pion	PROPN
admet-761	60	14	inc	inc	PROPN
admet-761	60	15	(	(	PUNCT
admet-761	60	16	billerica	billerica	PROPN
admet-761	60	17	,	,	PUNCT
admet-761	60	18	ma	ma	PROPN
admet-761	60	19	,	,	PUNCT
admet-761	60	20	usa	usa	PROPN
admet-761	60	21	)	)	PUNCT
admet-761	60	22	.	.	PUNCT
admet-761	61	1	this	this	DET
admet-761	61	2	instrument	instrument	NOUN
admet-761	61	3	is	be	AUX
admet-761	61	4	composed	compose	VERB
admet-761	61	5	of	of	ADP
admet-761	61	6	the	the	DET
admet-761	61	7	gut	gut	NOUN
admet-761	61	8	-	-	PUNCT
admet-761	61	9	boxtm	boxtm	NOUN
admet-761	61	10	and	and	CCONJ
admet-761	61	11	the	the	DET
admet-761	61	12	tempplate	tempplate	NOUN
admet-761	61	13	.	.	PUNCT
admet-761	62	1	the	the	DET
admet-761	62	2	gut	gut	NOUN
admet-761	62	3	-	-	PUNCT
admet-761	62	4	boxtm	boxtm	NOUN
admet-761	62	5	is	be	AUX
admet-761	62	6	a	a	DET
admet-761	62	7	mechanical	mechanical	ADJ
admet-761	62	8	device	device	NOUN
admet-761	62	9	used	use	VERB
admet-761	62	10	for	for	ADP
admet-761	62	11	the	the	DET
admet-761	62	12	pampa	pampa	NOUN
admet-761	62	13	assay	assay	VERB
admet-761	62	14	to	to	PART
admet-761	62	15	decrease	decrease	VERB
admet-761	62	16	the	the	DET
admet-761	62	17	permeation	permeation	NOUN
admet-761	62	18	time	time	NOUN
admet-761	62	19	and	and	CCONJ
admet-761	62	20	reduce	reduce	VERB
admet-761	62	21	the	the	DET
admet-761	62	22	unstirred	unstirred	ADJ
admet-761	62	23	water	water	NOUN
admet-761	62	24	layer	layer	NOUN
admet-761	62	25	(	(	PUNCT
admet-761	62	26	uwl	uwl	NOUN
admet-761	62	27	)	)	PUNCT
admet-761	62	28	thickness	thickness	NOUN
admet-761	62	29	that	that	PRON
admet-761	62	30	is	be	AUX
admet-761	62	31	always	always	ADV
admet-761	62	32	present	present	ADJ
admet-761	62	33	.	.	PUNCT
admet-761	63	1	the	the	DET
admet-761	63	2	tempplate	tempplate	NOUN
admet-761	63	3	is	be	AUX
admet-761	63	4	used	use	VERB
admet-761	63	5	for	for	ADP
admet-761	63	6	the	the	DET
admet-761	63	7	temperature	temperature	NOUN
admet-761	63	8	control	control	NOUN
admet-761	63	9	during	during	ADP
admet-761	63	10	plate	plate	NOUN
admet-761	63	11	incubation	incubation	NOUN
admet-761	63	12	.	.	PUNCT
admet-761	64	1	chromatographic	chromatographic	ADJ
admet-761	64	2	measurements	measurement	NOUN
admet-761	64	3	were	be	AUX
admet-761	64	4	performed	perform	VERB
admet-761	64	5	with	with	ADP
admet-761	64	6	a	a	DET
admet-761	64	7	waters	water	NOUN
admet-761	64	8	(	(	PUNCT
admet-761	64	9	milford	milford	NOUN
admet-761	64	10	,	,	PUNCT
admet-761	64	11	ma	ma	PROPN
admet-761	64	12	,	,	PUNCT
admet-761	64	13	usa	usa	PROPN
admet-761	64	14	)	)	PUNCT
admet-761	64	15	i	i	PROPN
admet-761	64	16	-	-	PUNCT
admet-761	64	17	class	class	NOUN
admet-761	64	18	uplc	uplc	ADJ
admet-761	64	19	with	with	ADP
admet-761	64	20	diode	diode	NOUN
admet-761	64	21	array	array	NOUN
admet-761	64	22	detector	detector	NOUN
admet-761	64	23	.	.	PUNCT
admet-761	65	1	instrument	instrument	NOUN
admet-761	65	2	control	control	NOUN
admet-761	65	3	and	and	CCONJ
admet-761	65	4	processing	processing	NOUN
admet-761	65	5	was	be	AUX
admet-761	65	6	performed	perform	VERB
admet-761	65	7	by	by	ADP
admet-761	65	8	empower	empower	NOUN
admet-761	65	9	.	.	PUNCT
admet-761	66	1	the	the	DET
admet-761	66	2	column	column	NOUN
admet-761	66	3	used	use	VERB
admet-761	66	4	for	for	ADP
admet-761	66	5	the	the	DET
admet-761	66	6	determinations	determination	NOUN
admet-761	66	7	was	be	AUX
admet-761	66	8	an	an	DET
admet-761	66	9	acquity	acquity	NOUN
admet-761	66	10	uplc	uplc	ADJ
admet-761	66	11	beh	beh	PROPN
admet-761	66	12	c18	c18	PROPN
admet-761	66	13	(	(	PUNCT
admet-761	66	14	50	50	NUM
admet-761	66	15	x	x	SYM
admet-761	66	16	2.1	2.1	NUM
admet-761	66	17	mm	mm	NOUN
admet-761	66	18	,	,	PUNCT
admet-761	66	19	1.7	1.7	NUM
admet-761	66	20	μm	μm	NUM
admet-761	66	21	)	)	PUNCT
admet-761	66	22	.	.	PUNCT
admet-761	67	1	skin	skin	NOUN
admet-761	67	2	-	-	PUNCT
admet-761	67	3	pampa	pampa	NOUN
admet-761	67	4	method	method	NOUN
admet-761	67	5	before	before	ADP
admet-761	67	6	permeation	permeation	NOUN
admet-761	67	7	assays	assay	NOUN
admet-761	68	1	,	,	PUNCT
admet-761	68	2	the	the	DET
admet-761	68	3	top	top	ADJ
admet-761	68	4	part	part	NOUN
admet-761	68	5	of	of	ADP
admet-761	68	6	the	the	DET
admet-761	68	7	skin	skin	NOUN
admet-761	68	8	-	-	PUNCT
admet-761	68	9	pampa	pampa	NOUN
admet-761	68	10	sandwich	sandwich	NOUN
admet-761	68	11	,	,	PUNCT
admet-761	68	12	which	which	PRON
admet-761	68	13	contains	contain	VERB
admet-761	68	14	the	the	DET
admet-761	68	15	membrane	membrane	NOUN
admet-761	68	16	,	,	PUNCT
admet-761	68	17	was	be	AUX
admet-761	68	18	hydrated	hydrated	ADJ
admet-761	68	19	overnight	overnight	ADV
admet-761	68	20	with	with	ADP
admet-761	68	21	the	the	DET
admet-761	68	22	hydration	hydration	NOUN
admet-761	68	23	solution	solution	NOUN
admet-761	68	24	.	.	PUNCT
admet-761	69	1	the	the	DET
admet-761	69	2	samples	sample	NOUN
admet-761	69	3	were	be	AUX
admet-761	69	4	dissolved	dissolve	VERB
admet-761	69	5	in	in	ADP
admet-761	69	6	diluted	dilute	VERB
admet-761	69	7	prisma	prisma	NOUN
admet-761	69	8	httm	httm	NOUN
admet-761	69	9	buffer	buffer	VERB
admet-761	69	10	solution	solution	NOUN
admet-761	69	11	at	at	ADP
admet-761	69	12	several	several	ADJ
admet-761	69	13	ph	ph	ADJ
admet-761	69	14	values	value	NOUN
admet-761	69	15	:	:	PUNCT
admet-761	69	16	25	25	NUM
admet-761	69	17	ml	ml	NOUN
admet-761	69	18	of	of	ADP
admet-761	69	19	concentrated	concentrate	VERB
admet-761	69	20	prisma	prisma	NOUN
admet-761	69	21	httm	httm	NOUN
admet-761	69	22	was	be	AUX
admet-761	69	23	diluted	dilute	VERB
admet-761	69	24	with	with	ADP
admet-761	69	25	water	water	NOUN
admet-761	69	26	to	to	ADP
admet-761	69	27	a	a	DET
admet-761	69	28	final	final	ADJ
admet-761	69	29	volume	volume	NOUN
admet-761	69	30	of	of	ADP
admet-761	69	31	1	1	NUM
admet-761	69	32	l	l	NOUN
admet-761	69	33	and	and	CCONJ
admet-761	69	34	then	then	ADV
admet-761	69	35	,	,	PUNCT
admet-761	69	36	different	different	ADJ
admet-761	69	37	solutions	solution	NOUN
admet-761	69	38	were	be	AUX
admet-761	69	39	prepared	prepare	VERB
admet-761	69	40	by	by	ADP
admet-761	69	41	ph	ph	ADJ
admet-761	69	42	adjustment	adjustment	NOUN
admet-761	69	43	between	between	ADP
admet-761	69	44	3	3	NUM
admet-761	69	45	and	and	CCONJ
admet-761	69	46	10	10	NUM
admet-761	69	47	with	with	ADP
admet-761	69	48	0.5	0.5	NUM
admet-761	69	49	m	m	PROPN
admet-761	69	50	naoh	naoh	NOUN
admet-761	69	51	(	(	PUNCT
admet-761	69	52	merck	merck	PROPN
admet-761	69	53	)	)	PUNCT
admet-761	69	54	.	.	PUNCT
admet-761	70	1	the	the	DET
admet-761	70	2	concentration	concentration	NOUN
admet-761	70	3	of	of	ADP
admet-761	70	4	the	the	DET
admet-761	70	5	sample	sample	NOUN
admet-761	70	6	solutions	solution	NOUN
admet-761	70	7	was	be	AUX
admet-761	70	8	50	50	NUM
admet-761	70	9	µm	µm	NOUN
admet-761	70	10	(	(	PUNCT
admet-761	70	11	containing	contain	VERB
admet-761	70	12	0.5	0.5	NUM
admet-761	70	13	%	%	NOUN
admet-761	70	14	v	v	ADP
admet-761	70	15	/	/	SYM
admet-761	70	16	v	v	NOUN
admet-761	70	17	dmso	dmso	NOUN
admet-761	70	18	)	)	PUNCT
admet-761	70	19	.	.	PUNCT
admet-761	71	1	skin	skin	NOUN
admet-761	71	2	-	-	PUNCT
admet-761	71	3	pampa	pampa	NOUN
admet-761	71	4	assays	assay	NOUN
admet-761	71	5	were	be	AUX
admet-761	71	6	carried	carry	VERB
admet-761	71	7	out	out	ADP
admet-761	71	8	under	under	ADP
admet-761	71	9	gradient	gradient	NOUN
admet-761	71	10	-	-	PUNCT
admet-761	71	11	ph	ph	NOUN
admet-761	71	12	conditions	condition	NOUN
admet-761	71	13	to	to	PART
admet-761	71	14	mimic	mimic	VERB
admet-761	71	15	the	the	DET
admet-761	71	16	ph	ph	NOUN
admet-761	71	17	change	change	NOUN
admet-761	71	18	between	between	ADP
admet-761	71	19	the	the	DET
admet-761	71	20	stratum	stratum	NOUN
admet-761	71	21	corneum	corneum	NOUN
admet-761	71	22	and	and	CCONJ
admet-761	71	23	the	the	DET
admet-761	71	24	underlying	underlie	VERB
admet-761	71	25	epidermis	epidermis	NOUN
admet-761	71	26	and	and	CCONJ
admet-761	71	27	dermis	dermis	NOUN
admet-761	71	28	.	.	PUNCT
admet-761	72	1	for	for	ADP
admet-761	72	2	this	this	DET
admet-761	72	3	reason	reason	NOUN
admet-761	72	4	,	,	PUNCT
admet-761	72	5	the	the	DET
admet-761	72	6	donor	donor	NOUN
admet-761	72	7	compartment	compartment	NOUN
admet-761	72	8	ph	ph	NOUN
admet-761	72	9	was	be	AUX
admet-761	72	10	varied	varied	ADJ
admet-761	72	11	from	from	ADP
admet-761	72	12	3	3	NUM
admet-761	72	13	to	to	ADP
admet-761	72	14	10	10	NUM
admet-761	72	15	and	and	CCONJ
admet-761	72	16	the	the	DET
admet-761	72	17	acceptor	acceptor	NOUN
admet-761	72	18	compartment	compartment	NOUN
admet-761	72	19	ph	ph	NOUN
admet-761	72	20	was	be	AUX
admet-761	72	21	maintained	maintain	VERB
admet-761	72	22	at	at	ADP
admet-761	72	23	ph	ph	PROPN
admet-761	72	24	7.4	7.4	NUM
admet-761	72	25	.	.	PUNCT
admet-761	73	1	this	this	DET
admet-761	73	2	gradient	gradient	NOUN
admet-761	73	3	-	-	PUNCT
admet-761	73	4	ph	ph	NOUN
admet-761	73	5	state	state	NOUN
admet-761	73	6	is	be	AUX
admet-761	73	7	the	the	DET
admet-761	73	8	first	first	ADJ
admet-761	73	9	sink	sink	NOUN
admet-761	73	10	condition	condition	NOUN
admet-761	73	11	in	in	ADP
admet-761	73	12	skin	skin	NOUN
admet-761	73	13	-	-	PUNCT
admet-761	73	14	pampa	pampa	NOUN
admet-761	73	15	.	.	PUNCT
admet-761	74	1	the	the	DET
admet-761	74	2	double	double	ADJ
admet-761	74	3	-	-	PUNCT
admet-761	74	4	sink	sink	NOUN
admet-761	74	5	condition	condition	NOUN
admet-761	74	6	that	that	PRON
admet-761	74	7	is	be	AUX
admet-761	74	8	usually	usually	ADV
admet-761	74	9	used	use	VERB
admet-761	74	10	in	in	ADP
admet-761	74	11	git	git	NOUN
admet-761	74	12	-	-	PUNCT
admet-761	74	13	pampa	pampa	NOUN
admet-761	74	14	consists	consist	VERB
admet-761	74	15	in	in	ADP
admet-761	74	16	taking	take	VERB
admet-761	74	17	advantage	advantage	NOUN
admet-761	74	18	of	of	ADP
admet-761	74	19	chemical	chemical	ADJ
admet-761	74	20	scavengers	scavenger	NOUN
admet-761	74	21	in	in	ADP
admet-761	74	22	the	the	DET
admet-761	74	23	receiver	receiver	ADJ
admet-761	74	24	compartment	compartment	NOUN
admet-761	74	25	to	to	PART
admet-761	74	26	make	make	VERB
admet-761	74	27	permeation	permeation	NOUN
admet-761	74	28	of	of	ADP
admet-761	74	29	lipophilic	lipophilic	ADJ
admet-761	74	30	compounds	compound	NOUN
admet-761	74	31	across	across	ADP
admet-761	74	32	the	the	DET
admet-761	74	33	membrane	membrane	NOUN
admet-761	74	34	unidirectional	unidirectional	NOUN
admet-761	74	35	.	.	PUNCT
admet-761	75	1	this	this	DET
admet-761	75	2	procedure	procedure	NOUN
admet-761	75	3	simulates	simulate	VERB
admet-761	75	4	the	the	DET
admet-761	75	5	situation	situation	NOUN
admet-761	75	6	present	present	ADJ
admet-761	75	7	in	in	ADP
admet-761	75	8	the	the	DET
admet-761	75	9	body	body	NOUN
admet-761	75	10	where	where	SCONJ
admet-761	75	11	blood	blood	NOUN
admet-761	75	12	flow	flow	NOUN
admet-761	75	13	and	and	CCONJ
admet-761	75	14	serum	serum	NOUN
admet-761	75	15	proteins	protein	NOUN
admet-761	75	16	constantly	constantly	ADV
admet-761	75	17	shift	shift	VERB
admet-761	75	18	the	the	DET
admet-761	75	19	concentration	concentration	NOUN
admet-761	75	20	gradient	gradient	NOUN
admet-761	75	21	to	to	PART
admet-761	75	22	favor	favor	VERB
admet-761	75	23	absorption	absorption	NOUN
admet-761	75	24	.	.	PUNCT
admet-761	76	1	however	however	ADV
admet-761	76	2	,	,	PUNCT
admet-761	76	3	this	this	DET
admet-761	76	4	double	double	ADJ
admet-761	76	5	-	-	PUNCT
admet-761	76	6	sink	sink	NOUN
admet-761	76	7	condition	condition	NOUN
admet-761	76	8	is	be	AUX
admet-761	76	9	not	not	PART
admet-761	76	10	used	use	VERB
admet-761	76	11	in	in	ADP
admet-761	76	12	skin	skin	NOUN
admet-761	76	13	-	-	PUNCT
admet-761	76	14	pampa	pampa	NOUN
admet-761	76	15	since	since	SCONJ
admet-761	76	16	this	this	DET
admet-761	76	17	additional	additional	ADJ
admet-761	76	18	shift	shift	NOUN
admet-761	76	19	is	be	AUX
admet-761	76	20	not	not	PART
admet-761	76	21	observed	observe	VERB
admet-761	76	22	through	through	ADP
admet-761	76	23	the	the	DET
admet-761	76	24	skin	skin	NOUN
admet-761	76	25	.	.	PUNCT
admet-761	77	1	before	before	ADP
admet-761	77	2	performing	perform	VERB
admet-761	77	3	the	the	DET
admet-761	77	4	skin	skin	NOUN
admet-761	77	5	-	-	PUNCT
admet-761	77	6	pampa	pampa	NOUN
admet-761	77	7	sandwich	sandwich	NOUN
admet-761	77	8	,	,	PUNCT
admet-761	77	9	the	the	DET
admet-761	77	10	donor	donor	NOUN
admet-761	77	11	compartment	compartment	NOUN
admet-761	77	12	(	(	PUNCT
admet-761	77	13	or	or	CCONJ
admet-761	77	14	bottom	bottom	ADJ
admet-761	77	15	plate	plate	NOUN
admet-761	77	16	)	)	PUNCT
admet-761	77	17	was	be	AUX
admet-761	77	18	prefilled	prefille	VERB
admet-761	77	19	with	with	ADP
admet-761	77	20	180	180	NUM
admet-761	77	21	µl	µl	NOUN
admet-761	77	22	(	(	PUNCT
admet-761	77	23	stirred	stir	VERB
admet-761	77	24	assay	assay	NOUN
admet-761	77	25	)	)	PUNCT
admet-761	77	26	or	or	CCONJ
admet-761	77	27	200	200	NUM
admet-761	77	28	µl	µl	PART
admet-761	77	29	(	(	PUNCT
admet-761	77	30	unstirred	unstirred	ADJ
admet-761	77	31	assay	assay	NOUN
admet-761	77	32	)	)	PUNCT
admet-761	77	33	of	of	ADP
admet-761	77	34	sample	sample	NOUN
admet-761	77	35	solutions	solution	NOUN
admet-761	77	36	and	and	CCONJ
admet-761	77	37	the	the	DET
admet-761	77	38	acceptor	acceptor	NOUN
admet-761	77	39	compartment	compartment	NOUN
admet-761	77	40	(	(	PUNCT
admet-761	77	41	or	or	CCONJ
admet-761	77	42	top	top	ADJ
admet-761	77	43	plate	plate	NOUN
admet-761	77	44	)	)	PUNCT
admet-761	77	45	was	be	AUX
admet-761	77	46	filled	fill	VERB
admet-761	77	47	with	with	ADP
admet-761	77	48	200	200	NUM
admet-761	77	49	µl	µl	NOUN
admet-761	77	50	of	of	ADP
admet-761	77	51	prisma	prisma	NOUN
admet-761	77	52	httm	httm	NOUN
admet-761	77	53	buffer	buffer	VERB
admet-761	77	54	solution	solution	NOUN
admet-761	77	55	at	at	ADP
admet-761	77	56	ph	ph	PROPN
admet-761	77	57	7.4	7.4	NUM
admet-761	77	58	.	.	PUNCT
admet-761	78	1	the	the	DET
admet-761	78	2	donor	donor	NOUN
admet-761	78	3	volume	volume	NOUN
admet-761	78	4	is	be	AUX
admet-761	78	5	decreased	decrease	VERB
admet-761	78	6	in	in	ADP
admet-761	78	7	stirred	stir	VERB
admet-761	78	8	assay	assay	ADV
admet-761	78	9	since	since	SCONJ
admet-761	78	10	the	the	DET
admet-761	78	11	stirring	stirring	NOUN
admet-761	78	12	bars	bar	NOUN
admet-761	78	13	have	have	VERB
admet-761	78	14	a	a	DET
admet-761	78	15	volume	volume	NOUN
admet-761	78	16	of	of	ADP
admet-761	78	17	20	20	NUM
admet-761	78	18	µl	µl	NOUN
admet-761	78	19	that	that	PRON
admet-761	78	20	can	can	AUX
admet-761	78	21	cause	cause	VERB
admet-761	78	22	overflow	overflow	NOUN
admet-761	78	23	.	.	PUNCT
admet-761	79	1	as	as	SCONJ
admet-761	79	2	it	it	PRON
admet-761	79	3	is	be	AUX
admet-761	79	4	mentioned	mention	VERB
admet-761	79	5	before	before	ADV
admet-761	79	6	,	,	PUNCT
admet-761	79	7	the	the	DET
admet-761	79	8	gut	gut	NOUN
admet-761	79	9	-	-	PUNCT
admet-761	79	10	boxtm	boxtm	NOUN
admet-761	79	11	was	be	AUX
admet-761	79	12	used	use	VERB
admet-761	79	13	to	to	PART
admet-761	79	14	stir	stir	VERB
admet-761	79	15	effectively	effectively	ADV
admet-761	79	16	.	.	PUNCT
admet-761	80	1	the	the	DET
admet-761	80	2	skin	skin	NOUN
admet-761	80	3	-	-	PUNCT
admet-761	80	4	pampa	pampa	NOUN
admet-761	80	5	sandwich	sandwich	NOUN
admet-761	80	6	was	be	AUX
admet-761	80	7	incubated	incubate	VERB
admet-761	80	8	at	at	ADP
admet-761	80	9	32	32	NUM
admet-761	80	10	°	°	NOUN
admet-761	80	11	c	c	NOUN
admet-761	80	12	.	.	PUNCT
admet-761	81	1	after	after	SCONJ
admet-761	81	2	the	the	DET
admet-761	81	3	permeation	permeation	NOUN
admet-761	81	4	time	time	NOUN
admet-761	81	5	was	be	AUX
admet-761	81	6	reached	reach	VERB
admet-761	81	7	,	,	PUNCT
admet-761	81	8	the	the	DET
admet-761	81	9	plates	plate	NOUN
admet-761	81	10	were	be	AUX
admet-761	81	11	separated	separate	VERB
admet-761	81	12	and	and	CCONJ
admet-761	81	13	the	the	DET
admet-761	81	14	compound	compound	NOUN
admet-761	81	15	concentration	concentration	NOUN
admet-761	81	16	in	in	ADP
admet-761	81	17	acceptor	acceptor	NOUN
admet-761	81	18	,	,	PUNCT
admet-761	81	19	donor	donor	NOUN
admet-761	81	20	and	and	CCONJ
admet-761	81	21	reference	reference	NOUN
admet-761	81	22	(	(	PUNCT
admet-761	81	23	initial	initial	ADJ
admet-761	81	24	sample	sample	NOUN
admet-761	81	25	solution	solution	NOUN
admet-761	81	26	)	)	PUNCT
admet-761	81	27	was	be	AUX
admet-761	81	28	determined	determine	VERB
admet-761	81	29	using	use	VERB
admet-761	81	30	uplc	uplc	ADJ
admet-761	81	31	-	-	PUNCT
admet-761	81	32	dad	dad	NOUN
admet-761	81	33	.	.	PUNCT
admet-761	82	1	chromatographic	chromatographic	ADJ
admet-761	82	2	conditions	condition	NOUN
admet-761	82	3	were	be	AUX
admet-761	82	4	:	:	PUNCT
admet-761	82	5	formic	formic	ADJ
admet-761	82	6	acid	acid	NOUN
admet-761	82	7	0.1	0.1	NUM
admet-761	82	8	%	%	NOUN
admet-761	82	9	and	and	CCONJ
admet-761	82	10	acetonitrile	acetonitrile	NOUN
admet-761	82	11	as	as	ADP
admet-761	82	12	mobile	mobile	ADJ
admet-761	82	13	phase	phase	NOUN
admet-761	82	14	,	,	PUNCT
admet-761	82	15	flow	flow	NOUN
admet-761	82	16	rate	rate	NOUN
admet-761	82	17	of	of	ADP
admet-761	82	18	0.8	0.8	NUM
admet-761	82	19	ml	ml	NOUN
admet-761	82	20	/	/	SYM
admet-761	82	21	min	min	NOUN
admet-761	82	22	,	,	PUNCT
admet-761	82	23	linear	linear	ADJ
admet-761	82	24	gradient	gradient	NOUN
admet-761	82	25	elution	elution	NOUN
admet-761	82	26	(	(	PUNCT
admet-761	82	27	linear	linear	ADJ
admet-761	82	28	gradient	gradient	NOUN
admet-761	82	29	from	from	ADP
admet-761	82	30	2	2	NUM
admet-761	82	31	%	%	NOUN
admet-761	82	32	to	to	ADP
admet-761	82	33	98	98	NUM
admet-761	82	34	%	%	NOUN
admet-761	82	35	of	of	ADP
admet-761	82	36	acetonitrile	acetonitrile	NOUN
admet-761	82	37	in	in	ADP
admet-761	82	38	2.5	2.5	NUM
admet-761	82	39	minutes	minute	NOUN
admet-761	82	40	)	)	PUNCT
admet-761	82	41	,	,	PUNCT
admet-761	82	42	injection	injection	NOUN
admet-761	82	43	volume	volume	NOUN
admet-761	82	44	of	of	ADP
admet-761	82	45	5	5	NUM
admet-761	82	46	μl	μl	ADV
admet-761	82	47	and	and	CCONJ
admet-761	82	48	the	the	DET
admet-761	82	49	detection	detection	NOUN
admet-761	82	50	by	by	ADP
admet-761	82	51	dad	dad	PROPN
admet-761	82	52	.	.	PROPN
admet-761	83	1	3	3	NUM
admet-761	83	2	to	to	PART
admet-761	83	3	5	5	NUM
admet-761	83	4	replicate	replicate	ADJ
admet-761	83	5	measurements	measurement	NOUN
admet-761	83	6	were	be	AUX
admet-761	83	7	done	do	VERB
admet-761	83	8	per	per	ADP
admet-761	83	9	compound	compound	NOUN
admet-761	83	10	and	and	CCONJ
admet-761	83	11	ph	ph	ADJ
admet-761	83	12	,	,	PUNCT
admet-761	83	13	and	and	CCONJ
admet-761	83	14	every	every	DET
admet-761	83	15	well	well	ADJ
admet-761	83	16	-	-	PUNCT
admet-761	83	17	plate	plate	NOUN
admet-761	83	18	contained	contain	VERB
admet-761	83	19	only	only	ADV
admet-761	83	20	one	one	NUM
admet-761	83	21	compound	compound	NOUN
admet-761	83	22	.	.	PUNCT
admet-761	84	1	calculation	calculation	NOUN
admet-761	84	2	methods	method	VERB
admet-761	84	3	the	the	DET
admet-761	84	4	skin	skin	NOUN
admet-761	84	5	-	-	PUNCT
admet-761	84	6	pampa	pampa	NOUN
admet-761	84	7	permeability	permeability	NOUN
admet-761	84	8	was	be	AUX
admet-761	84	9	calculated	calculate	VERB
admet-761	84	10	through	through	ADP
admet-761	84	11	pampa	pampa	NOUN
admet-761	84	12	equations	equation	NOUN
admet-761	84	13	.	.	PUNCT
admet-761	85	1	taking	take	VERB
admet-761	85	2	into	into	ADP
admet-761	85	3	account	account	NOUN
admet-761	85	4	the	the	DET
admet-761	85	5	membrane	membrane	NOUN
admet-761	85	6	retention	retention	NOUN
admet-761	85	7	(	(	PUNCT
admet-761	85	8	mole	mole	NOUN
admet-761	85	9	fraction	fraction	NOUN
admet-761	85	10	of	of	ADP
admet-761	85	11	the	the	DET
admet-761	85	12	sample	sample	NOUN
admet-761	85	13	that	that	PRON
admet-761	85	14	can	can	AUX
admet-761	85	15	be	be	AUX
admet-761	85	16	lost	lose	VERB
admet-761	85	17	in	in	ADP
admet-761	85	18	the	the	DET
admet-761	85	19	membrane	membrane	NOUN
admet-761	85	20	)	)	PUNCT
admet-761	85	21	under	under	ADP
admet-761	85	22	gradient	gradient	NOUN
admet-761	85	23	-	-	PUNCT
admet-761	85	24	ph	ph	NOUN
admet-761	85	25	conditions	condition	NOUN
admet-761	85	26	,	,	PUNCT
admet-761	85	27	the	the	DET
admet-761	85	28	equations	equation	NOUN
admet-761	85	29	are	be	AUX
admet-761	85	30	the	the	DET
admet-761	85	31	following	following	NOUN
admet-761	85	32	[	[	X
admet-761	85	33	17	17	NUM
admet-761	85	34	]	]	SYM
admet-761	85	35	:	:	PUNCT
admet-761	85	36	(	(	PUNCT
admet-761	85	37	1	1	X
admet-761	85	38	)	)	PUNCT
admet-761	85	39	(	(	PUNCT
admet-761	85	40	2	2	X
admet-761	85	41	)	)	PUNCT
admet-761	85	42	where	where	SCONJ
admet-761	85	43	pe	pe	PROPN
admet-761	85	44	is	be	AUX
admet-761	85	45	the	the	DET
admet-761	85	46	effective	effective	ADJ
admet-761	85	47	permeability	permeability	NOUN
admet-761	85	48	coefficient	coefficient	NOUN
admet-761	85	49	(	(	PUNCT
admet-761	85	50	cm	cm	NOUN
admet-761	85	51	/	/	SYM
admet-761	85	52	s	s	NOUN
admet-761	85	53	)	)	PUNCT
admet-761	85	54	,	,	PUNCT
admet-761	85	55	vd	vd	NOUN
admet-761	85	56	and	and	CCONJ
admet-761	85	57	va	va	PROPN
admet-761	85	58	are	be	AUX
admet-761	85	59	the	the	DET
admet-761	85	60	volume	volume	NOUN
admet-761	85	61	of	of	ADP
admet-761	85	62	solution	solution	NOUN
admet-761	85	63	in	in	ADP
admet-761	85	64	the	the	DET
admet-761	85	65	donor	donor	NOUN
admet-761	85	66	side	side	NOUN
admet-761	85	67	(	(	PUNCT
admet-761	85	68	180	180	NUM
admet-761	85	69	µl	µl	ADV
admet-761	85	70	stirred	stir	VERB
admet-761	85	71	assay	assay	ADV
admet-761	85	72	or	or	CCONJ
admet-761	85	73	200	200	NUM
admet-761	85	74	µl	µl	ADP
admet-761	85	75	unstirred	unstirred	ADJ
admet-761	85	76	assay	assay	NOUN
admet-761	85	77	)	)	PUNCT
admet-761	85	78	and	and	CCONJ
admet-761	85	79	acceptor	acceptor	NOUN
admet-761	85	80	side	side	NOUN
admet-761	85	81	(	(	PUNCT
admet-761	85	82	200	200	NUM
admet-761	85	83	µl	µl	NOUN
admet-761	85	84	)	)	PUNCT
admet-761	85	85	,	,	PUNCT
admet-761	85	86	respectively	respectively	ADV
admet-761	85	87	,	,	PUNCT
admet-761	85	88	a	a	PRON
admet-761	85	89	is	be	AUX
admet-761	85	90	the	the	DET
admet-761	85	91	membrane	membrane	NOUN
admet-761	85	92	area	area	NOUN
admet-761	85	93	(	(	PUNCT
admet-761	85	94	0.3	0.3	NUM
admet-761	85	95	cm2	cm2	NOUN
admet-761	85	96	)	)	PUNCT
admet-761	85	97	,	,	PUNCT
admet-761	85	98	t	t	PROPN
admet-761	85	99	is	be	AUX
admet-761	85	100	the	the	DET
admet-761	85	101	incubation	incubation	NOUN
admet-761	85	102	time	time	NOUN
admet-761	85	103	of	of	ADP
admet-761	85	104	the	the	DET
admet-761	85	105	experiment	experiment	NOUN
admet-761	85	106	(	(	PUNCT
admet-761	85	107	s	s	NOUN
admet-761	85	108	)	)	PUNCT
admet-761	85	109	,	,	PUNCT
admet-761	85	110	τss	τss	PROPN
admet-761	85	111	is	be	AUX
admet-761	85	112	the	the	DET
admet-761	85	113	lag	lag	NOUN
admet-761	85	114	time	time	NOUN
admet-761	85	115	(	(	PUNCT
admet-761	85	116	s	s	NOUN
admet-761	85	117	)	)	PUNCT
admet-761	86	1	[	[	X
admet-761	86	2	τss=(54·rm+1)·60	τss=(54·rm+1)·60	NOUN
admet-761	86	3	s	s	X
admet-761	86	4	]	]	X
admet-761	86	5	,	,	PUNCT
admet-761	86	6	εa	εa	PROPN
admet-761	86	7	is	be	AUX
admet-761	86	8	the	the	DET
admet-761	86	9	apparent	apparent	ADJ
admet-761	86	10	membrane	membrane	NOUN
admet-761	86	11	porosity	porosity	NOUN
admet-761	86	12	(	(	PUNCT
admet-761	86	13	0.76	0.76	NUM
admet-761	86	14	)	)	PUNCT
admet-761	86	15	,	,	PUNCT
admet-761	86	16	cd(t	cd(t	X
admet-761	86	17	)	)	PUNCT
admet-761	86	18	is	be	AUX
admet-761	86	19	the	the	DET
admet-761	86	20	concentration	concentration	NOUN
admet-761	86	21	in	in	ADP
admet-761	86	22	the	the	DET
admet-761	86	23	donor	donor	NOUN
admet-761	86	24	side	side	NOUN
admet-761	86	25	at	at	ADP
admet-761	86	26	time	time	NOUN
admet-761	86	27	t	t	PROPN
admet-761	86	28	,	,	PUNCT
admet-761	86	29	cd(0	cd(0	NOUN
admet-761	86	30	)	)	PUNCT
admet-761	86	31	is	be	AUX
admet-761	86	32	the	the	DET
admet-761	86	33	initial	initial	ADJ
admet-761	86	34	concentration	concentration	NOUN
admet-761	86	35	in	in	ADP
admet-761	86	36	the	the	DET
admet-761	86	37	donor	donor	NOUN
admet-761	86	38	side	side	NOUN
admet-761	86	39	,	,	PUNCT
admet-761	86	40	ca(t	ca(t	PUNCT
admet-761	86	41	)	)	PUNCT
admet-761	86	42	is	be	AUX
admet-761	86	43	the	the	DET
admet-761	86	44	concentration	concentration	NOUN
admet-761	86	45	in	in	ADP
admet-761	86	46	the	the	DET
admet-761	86	47	acceptor	acceptor	NOUN
admet-761	86	48	side	side	NOUN
admet-761	86	49	at	at	ADP
admet-761	86	50	time	time	NOUN
admet-761	86	51	t	t	PROPN
admet-761	86	52	,	,	PUNCT
admet-761	86	53	rm	rm	PROPN
admet-761	86	54	is	be	AUX
admet-761	86	55	the	the	DET
admet-761	86	56	membrane	membrane	NOUN
admet-761	86	57	retention	retention	NOUN
admet-761	86	58	and	and	CCONJ
admet-761	86	59	ra	ra	PROPN
admet-761	86	60	is	be	AUX
admet-761	86	61	the	the	DET
admet-761	86	62	sink	sink	NOUN
admet-761	86	63	asymmetry	asymmetry	NOUN
admet-761	86	64	ratio	ratio	NOUN
admet-761	86	65	(	(	PUNCT
admet-761	86	66	gradient	gradient	NOUN
admet-761	86	67	-	-	PUNCT
admet-761	86	68	ph	ph	VERB
admet-761	86	69	-	-	VERB
admet-761	86	70	induced	induced	ADJ
admet-761	86	71	)	)	PUNCT
admet-761	86	72	,	,	PUNCT
admet-761	86	73	defined	define	VERB
admet-761	86	74	as	as	ADP
admet-761	86	75	:	:	PUNCT
admet-761	86	76	(	(	PUNCT
admet-761	86	77	3	3	X
admet-761	86	78	)	)	PUNCT
admet-761	86	79	when	when	SCONJ
admet-761	86	80	the	the	DET
admet-761	86	81	ph	ph	NOUN
admet-761	86	82	is	be	AUX
admet-761	86	83	different	different	ADJ
admet-761	86	84	in	in	ADP
admet-761	86	85	the	the	DET
admet-761	86	86	two	two	NUM
admet-761	86	87	sides	side	NOUN
admet-761	86	88	of	of	ADP
admet-761	86	89	the	the	DET
admet-761	86	90	membrane	membrane	NOUN
admet-761	86	91	,	,	PUNCT
admet-761	86	92	a	a	DET
admet-761	86	93	gradient	gradient	NOUN
admet-761	86	94	-	-	PUNCT
admet-761	86	95	ph	ph	NOUN
admet-761	86	96	is	be	AUX
admet-761	86	97	created	create	VERB
admet-761	86	98	and	and	CCONJ
admet-761	86	99	the	the	DET
admet-761	86	100	permeation	permeation	NOUN
admet-761	86	101	of	of	ADP
admet-761	86	102	ionizable	ionizable	ADJ
admet-761	86	103	molecules	molecule	NOUN
admet-761	86	104	can	can	AUX
admet-761	86	105	be	be	AUX
admet-761	86	106	altered	alter	VERB
admet-761	86	107	.	.	PUNCT
admet-761	87	1	this	this	DET
admet-761	87	2	gradient	gradient	NOUN
admet-761	87	3	-	-	PUNCT
admet-761	87	4	ph	ph	NOUN
admet-761	87	5	implies	imply	VERB
admet-761	87	6	two	two	NUM
admet-761	87	7	different	different	ADJ
admet-761	87	8	permeability	permeability	NOUN
admet-761	87	9	coefficients	coefficient	NOUN
admet-761	87	10	,	,	PUNCT
admet-761	87	11	one	one	NUM
admet-761	87	12	denoted	denote	VERB
admet-761	87	13	by	by	ADP
admet-761	87	14	the	the	DET
admet-761	87	15	superscript	superscript	PROPN
admet-761	87	16	(	(	PUNCT
admet-761	87	17	d→a	d→a	PROPN
admet-761	87	18	)	)	PUNCT
admet-761	87	19	,	,	PUNCT
admet-761	87	20	associated	associate	VERB
admet-761	87	21	with	with	ADP
admet-761	87	22	donor	donor	NOUN
admet-761	87	23	to	to	ADP
admet-761	87	24	acceptor	acceptor	NOUN
admet-761	87	25	flux	flux	NOUN
admet-761	87	26	,	,	PUNCT
admet-761	87	27	and	and	CCONJ
admet-761	87	28	the	the	DET
admet-761	87	29	other	other	ADJ
admet-761	87	30	denoted	denote	VERB
admet-761	87	31	by	by	ADP
admet-761	87	32	the	the	DET
admet-761	87	33	superscript	superscript	PROPN
admet-761	87	34	(	(	PUNCT
admet-761	87	35	a→d	a→d	NUM
admet-761	87	36	)	)	PUNCT
admet-761	87	37	,	,	PUNCT
admet-761	87	38	corresponding	correspond	VERB
admet-761	87	39	to	to	ADP
admet-761	87	40	the	the	DET
admet-761	87	41	reverse	reverse	NOUN
admet-761	87	42	-	-	PUNCT
admet-761	87	43	direction	direction	NOUN
admet-761	87	44	flux	flux	NOUN
admet-761	87	45	.	.	PUNCT
admet-761	88	1	as	as	SCONJ
admet-761	88	2	equation	equation	NOUN
admet-761	88	3	(	(	PUNCT
admet-761	88	4	3	3	X
admet-761	88	5	)	)	PUNCT
admet-761	88	6	has	have	VERB
admet-761	88	7	two	two	NUM
admet-761	88	8	unknowns	unknown	NOUN
admet-761	88	9	,	,	PUNCT
admet-761	88	10	pe(a→d	pe(a→d	NOUN
admet-761	88	11	)	)	PUNCT
admet-761	88	12	and	and	CCONJ
admet-761	88	13	pe(d→a	pe(d→a	NOUN
admet-761	88	14	)	)	PUNCT
admet-761	88	15	,	,	PUNCT
admet-761	88	16	the	the	DET
admet-761	88	17	following	follow	VERB
admet-761	88	18	method	method	NOUN
admet-761	88	19	is	be	AUX
admet-761	88	20	used	use	VERB
admet-761	88	21	to	to	PART
admet-761	88	22	solve	solve	VERB
admet-761	88	23	the	the	DET
admet-761	88	24	equation	equation	NOUN
admet-761	88	25	:	:	PUNCT
admet-761	88	26	at	at	ADP
admet-761	88	27	least	least	ADV
admet-761	88	28	two	two	NUM
admet-761	88	29	assays	assay	NOUN
admet-761	88	30	are	be	AUX
admet-761	88	31	done	do	VERB
admet-761	88	32	,	,	PUNCT
admet-761	88	33	one	one	NUM
admet-761	88	34	with	with	ADP
admet-761	88	35	gradient	gradient	NOUN
admet-761	88	36	-	-	PUNCT
admet-761	88	37	ph	ph	NOUN
admet-761	88	38	and	and	CCONJ
admet-761	88	39	the	the	DET
admet-761	88	40	other	other	ADJ
admet-761	88	41	with	with	ADP
admet-761	88	42	iso	iso	NOUN
admet-761	88	43	-	-	PUNCT
admet-761	88	44	ph	ph	VERB
admet-761	88	45	,	,	PUNCT
admet-761	88	46	that	that	ADV
admet-761	88	47	is	is	ADV
admet-761	88	48	,	,	PUNCT
admet-761	88	49	the	the	DET
admet-761	88	50	same	same	ADJ
admet-761	88	51	ph	ph	NOUN
admet-761	88	52	at	at	ADP
admet-761	88	53	both	both	DET
admet-761	88	54	compartments	compartment	NOUN
admet-761	88	55	.	.	PUNCT
admet-761	89	1	for	for	ADP
admet-761	89	2	iso	iso	NOUN
admet-761	89	3	-	-	PUNCT
admet-761	89	4	ph	ph	ADJ
admet-761	89	5	,	,	PUNCT
admet-761	89	6	pe(a→d	pe(a→d	NOUN
admet-761	89	7	)	)	PUNCT
admet-761	89	8	=	=	SYM
admet-761	89	9	pe(d→a	pe(d→a	NOUN
admet-761	89	10	)	)	PUNCT
admet-761	89	11	.	.	PUNCT
admet-761	90	1	therefore	therefore	ADV
admet-761	90	2	,	,	PUNCT
admet-761	90	3	pe(a→d	pe(a→d	NOUN
admet-761	90	4	)	)	PUNCT
admet-761	90	5	can	can	AUX
admet-761	90	6	be	be	AUX
admet-761	90	7	solved	solve	VERB
admet-761	90	8	directly	directly	ADV
admet-761	90	9	using	use	VERB
admet-761	90	10	the	the	DET
admet-761	90	11	iso	iso	NOUN
admet-761	90	12	-	-	PUNCT
admet-761	90	13	ph	ph	NOUN
admet-761	90	14	equation	equation	NOUN
admet-761	90	15	:	:	PUNCT
admet-761	90	16	(	(	PUNCT
admet-761	90	17	4	4	X
admet-761	90	18	)	)	PUNCT
admet-761	90	19	where	where	SCONJ
admet-761	90	20	rv	rv	PROPN
admet-761	90	21	is	be	AUX
admet-761	90	22	the	the	DET
admet-761	90	23	aqueous	aqueous	ADJ
admet-761	90	24	compartment	compartment	NOUN
admet-761	90	25	volume	volume	NOUN
admet-761	90	26	ratio	ratio	NOUN
admet-761	90	27	,	,	PUNCT
admet-761	90	28	defined	define	VERB
admet-761	90	29	as	as	ADP
admet-761	90	30	:	:	PUNCT
admet-761	90	31	(	(	PUNCT
admet-761	90	32	5	5	NUM
admet-761	90	33	)	)	PUNCT
admet-761	90	34	then	then	ADV
admet-761	90	35	,	,	PUNCT
admet-761	90	36	eq	eq	NOUN
admet-761	90	37	.	.	PUNCT
admet-761	91	1	(	(	PUNCT
admet-761	91	2	1	1	X
admet-761	91	3	)	)	PUNCT
admet-761	91	4	is	be	AUX
admet-761	91	5	iteratively	iteratively	ADV
admet-761	91	6	solved	solve	VERB
admet-761	91	7	for	for	ADP
admet-761	91	8	pe(d→a	pe(d→a	NOUN
admet-761	91	9	)	)	PUNCT
admet-761	91	10	.	.	PUNCT
admet-761	92	1	initially	initially	ADV
admet-761	92	2	,	,	PUNCT
admet-761	92	3	ra	ra	PROPN
admet-761	92	4	is	be	AUX
admet-761	92	5	assumed	assume	VERB
admet-761	92	6	to	to	PART
admet-761	92	7	be	be	AUX
admet-761	92	8	rv	rv	PROPN
admet-761	92	9	,	,	PUNCT
admet-761	92	10	but	but	CCONJ
admet-761	92	11	with	with	ADP
admet-761	92	12	each	each	DET
admet-761	92	13	iteration	iteration	NOUN
admet-761	92	14	,	,	PUNCT
admet-761	92	15	the	the	DET
admet-761	92	16	ra	ra	PROPN
admet-761	92	17	estimation	estimation	NOUN
admet-761	92	18	is	be	AUX
admet-761	92	19	improved	improve	VERB
admet-761	92	20	by	by	ADP
admet-761	92	21	using	use	VERB
admet-761	92	22	the	the	DET
admet-761	92	23	calculated	calculated	ADJ
admet-761	92	24	pe(d→a	pe(d→a	NOUN
admet-761	92	25	)	)	PUNCT
admet-761	92	26	.	.	PUNCT
admet-761	93	1	the	the	DET
admet-761	93	2	process	process	NOUN
admet-761	93	3	continues	continue	VERB
admet-761	93	4	until	until	SCONJ
admet-761	93	5	self	self	NOUN
admet-761	93	6	-	-	PUNCT
admet-761	93	7	consistency	consistency	NOUN
admet-761	93	8	is	be	AUX
admet-761	93	9	reached	reach	VERB
admet-761	93	10	within	within	ADP
admet-761	93	11	the	the	DET
admet-761	93	12	precision	precision	NOUN
admet-761	93	13	required	require	VERB
admet-761	93	14	(	(	PUNCT
admet-761	93	15	0.001	0.001	NUM
admet-761	93	16	)	)	PUNCT
admet-761	93	17	.	.	PUNCT
admet-761	94	1	the	the	DET
admet-761	94	2	solver	solver	ADJ
admet-761	94	3	utility	utility	NOUN
admet-761	94	4	from	from	ADP
admet-761	94	5	microsoft	microsoft	PROPN
admet-761	94	6	excel	excel	PROPN
admet-761	94	7	was	be	AUX
admet-761	94	8	used	use	VERB
admet-761	94	9	for	for	ADP
admet-761	94	10	the	the	DET
admet-761	94	11	iterative	iterative	NOUN
admet-761	94	12	process	process	NOUN
admet-761	94	13	.	.	PUNCT
admet-761	95	1	results	result	NOUN
admet-761	95	2	and	and	CCONJ
admet-761	95	3	discussion	discussion	NOUN
admet-761	95	4	optimization	optimization	NOUN
admet-761	95	5	of	of	ADP
admet-761	95	6	skin	skin	NOUN
admet-761	95	7	-	-	PUNCT
admet-761	95	8	pampa	pampa	NOUN
admet-761	95	9	assay	assay	NOUN
admet-761	95	10	conditions	condition	NOUN
admet-761	95	11	:	:	PUNCT
admet-761	95	12	incubation	incubation	NOUN
admet-761	95	13	time	time	NOUN
admet-761	95	14	and	and	CCONJ
admet-761	95	15	stirring	stir	VERB
admet-761	95	16	to	to	PART
admet-761	95	17	evaluate	evaluate	VERB
admet-761	95	18	the	the	DET
admet-761	95	19	different	different	ADJ
admet-761	95	20	parameters	parameter	NOUN
admet-761	95	21	that	that	PRON
admet-761	95	22	affect	affect	VERB
admet-761	95	23	skin	skin	NOUN
admet-761	95	24	-	-	PUNCT
admet-761	95	25	pampa	pampa	NOUN
admet-761	95	26	permeability	permeability	NOUN
admet-761	95	27	and	and	CCONJ
admet-761	95	28	to	to	PART
admet-761	95	29	establish	establish	VERB
admet-761	95	30	general	general	ADJ
admet-761	95	31	assay	assay	NOUN
admet-761	95	32	conditions	condition	NOUN
admet-761	95	33	for	for	ADP
admet-761	95	34	skin	skin	NOUN
admet-761	95	35	-	-	PUNCT
admet-761	95	36	pampa	pampa	NOUN
admet-761	95	37	determinations	determination	NOUN
admet-761	95	38	in	in	ADP
admet-761	95	39	solution	solution	NOUN
admet-761	95	40	,	,	PUNCT
admet-761	95	41	the	the	DET
admet-761	95	42	permeability	permeability	NOUN
admet-761	95	43	of	of	ADP
admet-761	95	44	9	9	NUM
admet-761	95	45	drugs	drug	NOUN
admet-761	95	46	with	with	ADP
admet-761	95	47	different	different	ADJ
admet-761	95	48	acid	acid	NOUN
admet-761	95	49	-	-	PUNCT
admet-761	95	50	base	base	NOUN
admet-761	95	51	properties	property	NOUN
admet-761	95	52	,	,	PUNCT
admet-761	95	53	lipophilicity	lipophilicity	NOUN
admet-761	95	54	,	,	PUNCT
admet-761	95	55	and	and	CCONJ
admet-761	95	56	in	in	ADP
admet-761	95	57	vitro	vitro	X
admet-761	95	58	franz	franz	PROPN
admet-761	95	59	cell	cell	NOUN
admet-761	95	60	human	human	ADJ
admet-761	95	61	skin	skin	NOUN
admet-761	95	62	permeability	permeability	NOUN
admet-761	95	63	values	value	NOUN
admet-761	95	64	(	(	PUNCT
admet-761	95	65	kp	kp	INTJ
admet-761	95	66	,	,	PUNCT
admet-761	95	67	units	unit	NOUN
admet-761	95	68	in	in	ADP
admet-761	95	69	cm	cm	PROPN
admet-761	95	70	/	/	SYM
admet-761	95	71	s	s	PART
admet-761	95	72	)	)	PUNCT
admet-761	95	73	was	be	AUX
admet-761	95	74	investigated	investigate	VERB
admet-761	95	75	.	.	PUNCT
admet-761	96	1	to	to	PART
admet-761	96	2	assure	assure	VERB
admet-761	96	3	the	the	DET
admet-761	96	4	neutral	neutral	ADJ
admet-761	96	5	form	form	NOUN
admet-761	96	6	,	,	PUNCT
admet-761	96	7	acidic	acidic	ADJ
admet-761	96	8	compounds	compound	NOUN
admet-761	96	9	(	(	PUNCT
admet-761	96	10	flurbiprofen	flurbiprofen	NOUN
admet-761	96	11	,	,	PUNCT
admet-761	96	12	ibuprofen	ibuprofen	NOUN
admet-761	96	13	,	,	PUNCT
admet-761	96	14	naproxen	naproxen	NOUN
admet-761	96	15	and	and	CCONJ
admet-761	96	16	5	5	NUM
admet-761	96	17	-	-	PUNCT
admet-761	96	18	fluorouracil	fluorouracil	NOUN
admet-761	96	19	)	)	PUNCT
admet-761	96	20	were	be	AUX
admet-761	96	21	dissolved	dissolve	VERB
admet-761	96	22	in	in	ADP
admet-761	96	23	prisma	prisma	NOUN
admet-761	96	24	httm	httm	NOUN
admet-761	96	25	buffer	buffer	VERB
admet-761	96	26	solution	solution	NOUN
admet-761	96	27	at	at	ADP
admet-761	96	28	ph	ph	PROPN
admet-761	96	29	3.0	3.0	NUM
admet-761	96	30	.	.	PUNCT
admet-761	97	1	aminopyrine	aminopyrine	PROPN
admet-761	97	2	,	,	PUNCT
admet-761	97	3	a	a	DET
admet-761	97	4	basic	basic	ADJ
admet-761	97	5	compound	compound	NOUN
admet-761	97	6	with	with	ADP
admet-761	97	7	a	a	DET
admet-761	97	8	aqueous	aqueous	ADJ
admet-761	97	9	pka	pka	NOUN
admet-761	97	10	value	value	NOUN
admet-761	97	11	of	of	ADP
admet-761	97	12	5	5	NUM
admet-761	97	13	,	,	PUNCT
admet-761	97	14	was	be	AUX
admet-761	97	15	dissolved	dissolve	VERB
admet-761	97	16	in	in	ADP
admet-761	97	17	the	the	DET
admet-761	97	18	buffer	buffer	NOUN
admet-761	97	19	solution	solution	NOUN
admet-761	97	20	at	at	ADP
admet-761	97	21	ph	ph	PROPN
admet-761	97	22	7.0	7.0	NUM
admet-761	97	23	.	.	PUNCT
admet-761	98	1	the	the	DET
admet-761	98	2	neutral	neutral	ADJ
admet-761	98	3	compounds	compound	NOUN
admet-761	98	4	(	(	PUNCT
admet-761	98	5	progesterone	progesterone	NOUN
admet-761	98	6	,	,	PUNCT
admet-761	98	7	griseofulvin	griseofulvin	NOUN
admet-761	98	8	,	,	PUNCT
admet-761	98	9	digitoxin	digitoxin	PROPN
admet-761	98	10	and	and	CCONJ
admet-761	98	11	hydrocortisone	hydrocortisone	PROPN
admet-761	98	12	)	)	PUNCT
admet-761	98	13	were	be	AUX
admet-761	98	14	dissolved	dissolve	VERB
admet-761	98	15	at	at	ADP
admet-761	98	16	ph	ph	PROPN
admet-761	98	17	3.0	3.0	NUM
admet-761	98	18	.	.	PUNCT
admet-761	99	1	the	the	DET
admet-761	99	2	skin	skin	NOUN
admet-761	99	3	-	-	PUNCT
admet-761	99	4	pampa	pampa	NOUN
admet-761	99	5	sandwiches	sandwich	NOUN
admet-761	99	6	were	be	AUX
admet-761	99	7	incubated	incubate	VERB
admet-761	99	8	(	(	PUNCT
admet-761	99	9	with	with	ADP
admet-761	99	10	and	and	CCONJ
admet-761	99	11	without	without	ADP
admet-761	99	12	stirring	stirring	NOUN
admet-761	99	13	)	)	PUNCT
admet-761	99	14	for	for	ADP
admet-761	99	15	30	30	NUM
admet-761	99	16	min	min	NOUN
admet-761	99	17	,	,	PUNCT
admet-761	99	18	4	4	NUM
admet-761	99	19	h	h	NOUN
admet-761	99	20	and	and	CCONJ
admet-761	99	21	24	24	NUM
admet-761	99	22	h.	h.	NOUN
admet-761	99	23	the	the	DET
admet-761	99	24	logarithm	logarithm	NOUN
admet-761	99	25	of	of	ADP
admet-761	99	26	skin	skin	NOUN
admet-761	99	27	-	-	PUNCT
admet-761	99	28	pampa	pampa	NOUN
admet-761	99	29	permeability	permeability	NOUN
admet-761	99	30	values	value	NOUN
admet-761	99	31	(	(	PUNCT
admet-761	99	32	log	log	VERB
admet-761	99	33	pe	pe	INTJ
admet-761	99	34	)	)	PUNCT
admet-761	99	35	and	and	CCONJ
admet-761	99	36	the	the	DET
admet-761	99	37	corresponding	corresponding	ADJ
admet-761	99	38	membrane	membrane	NOUN
admet-761	99	39	retention	retention	NOUN
admet-761	99	40	are	be	AUX
admet-761	99	41	presented	present	VERB
admet-761	99	42	in	in	ADP
admet-761	99	43	table	table	NOUN
admet-761	99	44	1	1	NUM
admet-761	99	45	.	.	PUNCT
admet-761	100	1	this	this	DET
admet-761	100	2	table	table	NOUN
admet-761	100	3	also	also	ADV
admet-761	100	4	shows	show	VERB
admet-761	100	5	the	the	DET
admet-761	100	6	logarithm	logarithm	NOUN
admet-761	100	7	of	of	ADP
admet-761	100	8	the	the	DET
admet-761	100	9	octanol	octanol	NOUN
admet-761	100	10	-	-	PUNCT
admet-761	100	11	water	water	NOUN
admet-761	100	12	partition	partition	NOUN
admet-761	100	13	coefficient	coefficient	NOUN
admet-761	100	14	(	(	PUNCT
admet-761	100	15	log	log	VERB
admet-761	100	16	po	po	PROPN
admet-761	100	17	/	/	SYM
admet-761	100	18	w	w	PROPN
admet-761	100	19	)	)	PUNCT
admet-761	100	20	and	and	CCONJ
admet-761	100	21	the	the	DET
admet-761	100	22	logarithm	logarithm	NOUN
admet-761	100	23	of	of	ADP
admet-761	100	24	human	human	ADJ
admet-761	100	25	skin	skin	NOUN
admet-761	100	26	permeation	permeation	NOUN
admet-761	100	27	coefficient	coefficient	NOUN
admet-761	100	28	(	(	PUNCT
admet-761	100	29	log	log	NOUN
admet-761	100	30	kp	kp	NOUN
admet-761	100	31	)	)	PUNCT
admet-761	100	32	for	for	ADP
admet-761	100	33	each	each	DET
admet-761	100	34	compound	compound	NOUN
admet-761	100	35	.	.	PUNCT
admet-761	101	1	the	the	DET
admet-761	101	2	log	log	NOUN
admet-761	101	3	kp	kp	PROPN
admet-761	101	4	data	data	PROPN
admet-761	101	5	was	be	AUX
admet-761	101	6	obtained	obtain	VERB
admet-761	101	7	from	from	ADP
admet-761	101	8	zhang	zhang	PROPN
admet-761	101	9	et	et	PROPN
admet-761	101	10	al	al	PROPN
admet-761	101	11	.	.	PROPN
admet-761	101	12	database	database	PROPN
admet-761	102	1	[	[	X
admet-761	102	2	18	18	NUM
admet-761	102	3	]	]	PUNCT
admet-761	102	4	.	.	PUNCT
admet-761	103	1	this	this	DET
admet-761	103	2	database	database	NOUN
admet-761	103	3	provides	provide	VERB
admet-761	103	4	an	an	DET
admet-761	103	5	extensive	extensive	ADJ
admet-761	103	6	and	and	CCONJ
admet-761	103	7	carefully	carefully	ADV
admet-761	103	8	examined	examine	VERB
admet-761	103	9	data	datum	NOUN
admet-761	103	10	set	set	NOUN
admet-761	103	11	,	,	PUNCT
admet-761	103	12	where	where	SCONJ
admet-761	103	13	experimental	experimental	ADJ
admet-761	103	14	log	log	NOUN
admet-761	103	15	kp	kp	PROPN
admet-761	103	16	data	datum	NOUN
admet-761	103	17	from	from	ADP
admet-761	103	18	literature	literature	NOUN
admet-761	103	19	is	be	AUX
admet-761	103	20	corrected	correct	VERB
admet-761	103	21	for	for	ADP
admet-761	103	22	ionization	ionization	NOUN
admet-761	103	23	in	in	ADP
admet-761	103	24	water	water	NOUN
admet-761	103	25	and	and	CCONJ
admet-761	103	26	for	for	ADP
admet-761	103	27	the	the	DET
admet-761	103	28	temperature	temperature	NOUN
admet-761	103	29	at	at	ADP
admet-761	103	30	37	37	NUM
admet-761	103	31	°	°	NOUN
admet-761	103	32	c	c	NOUN
admet-761	104	1	.	.	PUNCT
admet-761	104	2	table	table	NOUN
admet-761	104	3	1	1	NUM
admet-761	104	4	.	.	PUNCT
admet-761	105	1	log	log	VERB
admet-761	105	2	pe	pe	NOUN
admet-761	105	3	values	value	NOUN
admet-761	105	4	of	of	ADP
admet-761	105	5	the	the	DET
admet-761	105	6	neutral	neutral	ADJ
admet-761	105	7	form	form	NOUN
admet-761	105	8	of	of	ADP
admet-761	105	9	the	the	DET
admet-761	105	10	drugs	drug	NOUN
admet-761	105	11	,	,	PUNCT
admet-761	105	12	obtained	obtain	VERB
admet-761	105	13	from	from	ADP
admet-761	105	14	skin	skin	NOUN
admet-761	105	15	-	-	PUNCT
admet-761	105	16	pampa	pampa	NOUN
admet-761	105	17	assays	assay	NOUN
admet-761	105	18	with	with	ADP
admet-761	105	19	and	and	CCONJ
admet-761	105	20	without	without	ADP
admet-761	105	21	stirring	stir	VERB
admet-761	105	22	at	at	ADP
admet-761	105	23	different	different	ADJ
admet-761	105	24	incubation	incubation	NOUN
admet-761	105	25	times	time	NOUN
admet-761	105	26	.	.	PUNCT
admet-761	106	1	log	log	VERB
admet-761	106	2	pe	pe	INTJ
admet-761	106	3	with	with	ADP
admet-761	106	4	stirring	stir	VERB
admet-761	106	5	without	without	ADP
admet-761	106	6	stirring	stir	VERB
admet-761	106	7	solutes	solute	NOUN
admet-761	106	8	log	log	VERB
admet-761	106	9	kp	kp	PROPN
admet-761	107	1	[	[	X
admet-761	107	2	18	18	NUM
admet-761	107	3	]	]	X
admet-761	107	4	log	log	NOUN
admet-761	107	5	po	po	NOUN
admet-761	107	6	/	/	SYM
admet-761	107	7	w	w	PROPN
admet-761	108	1	[	[	X
admet-761	108	2	19	19	NUM
admet-761	108	3	]	]	X
admet-761	108	4	pka	pka	X
admet-761	108	5	30	30	NUM
admet-761	108	6	min	min	NOUN
admet-761	108	7	4	4	NUM
admet-761	108	8	h	h	NOUN
admet-761	108	9	24	24	NUM
admet-761	108	10	h	h	NOUN
admet-761	108	11	30	30	NUM
admet-761	108	12	min	min	NOUN
admet-761	108	13	4	4	NUM
admet-761	108	14	h	h	NOUN
admet-761	108	15	24	24	NUM
admet-761	108	16	h	h	NOUN
admet-761	108	17	5	5	NUM
admet-761	108	18	-	-	PUNCT
admet-761	108	19	fluorouracil	fluorouracil	NOUN
admet-761	108	20	-6.82	-6.82	NUM
admet-761	108	21	-0.89	-0.89	NUM
admet-761	108	22	7.86	7.86	NUM
admet-761	108	23	a	a	DET
admet-761	108	24	-5.77(±0.02	-5.77(±0.02	NOUN
admet-761	108	25	)	)	PUNCT
admet-761	108	26	-6.16(±0.03	-6.16(±0.03	ADJ
admet-761	108	27	)	)	PUNCT
admet-761	108	28	-6.47(±0.22	-6.47(±0.22	NOUN
admet-761	108	29	)	)	PUNCT
admet-761	108	30	-6.07(±0.06	-6.07(±0.06	NOUN
admet-761	108	31	)	)	PUNCT
admet-761	108	32	aminopyrine	aminopyrine	NOUN
admet-761	108	33	-6.55	-6.55	NUM
admet-761	108	34	0.80	0.80	NUM
admet-761	108	35	5.00	5.00	NUM
admet-761	108	36	b	b	PRON
admet-761	108	37	-5.88(±0.07	-5.88(±0.07	NOUN
admet-761	108	38	)	)	PUNCT
admet-761	108	39	-5.65(±0.01	-5.65(±0.01	NOUN
admet-761	108	40	)	)	PUNCT
admet-761	108	41	-5.17(±0.06	-5.17(±0.06	ADJ
admet-761	108	42	)	)	PUNCT
admet-761	108	43	-5.79(±0.06	-5.79(±0.06	ADJ
admet-761	108	44	)	)	PUNCT
admet-761	108	45	-5.46(±0.06	-5.46(±0.06	ADV
admet-761	108	46	)	)	PUNCT
admet-761	108	47	-5.22(±0.02	-5.22(±0.02	PROPN
admet-761	108	48	)	)	PUNCT
admet-761	108	49	digitoxin	digitoxin	PROPN
admet-761	108	50	-8.15	-8.15	NUM
admet-761	108	51	2.83	2.83	NUM
admet-761	108	52	-6.42(±0.27	-6.42(±0.27	ADJ
admet-761	108	53	)	)	PUNCT
admet-761	108	54	-6.34(±0.13	-6.34(±0.13	NUM
admet-761	108	55	)	)	PUNCT
admet-761	108	56	flurbiprofen	flurbiprofen	NOUN
admet-761	108	57	-4.72	-4.72	NOUN
admet-761	108	58	4.16	4.16	NUM
admet-761	108	59	4.19	4.19	NUM
admet-761	108	60	c	c	NOUN
admet-761	108	61	-2.98(±0.13	-2.98(±0.13	PRON
admet-761	108	62	)	)	PUNCT
admet-761	108	63	-3.69(±0.02	-3.69(±0.02	NOUN
admet-761	108	64	)	)	PUNCT
admet-761	109	1	-3.54(±0.06	-3.54(±0.06	NOUN
admet-761	109	2	)	)	PUNCT
admet-761	109	3	-3.85(±0.03	-3.85(±0.03	ADJ
admet-761	109	4	)	)	PUNCT
admet-761	109	5	griseofulvin	griseofulvin	NOUN
admet-761	109	6	-6.44	-6.44	NUM
admet-761	109	7	2.18	2.18	NUM
admet-761	109	8	-5.61(±0.01	-5.61(±0.01	ADJ
admet-761	109	9	)	)	PUNCT
admet-761	109	10	-5.25(±0.10	-5.25(±0.10	NOUN
admet-761	109	11	)	)	PUNCT
admet-761	109	12	-5.12(±0.02	-5.12(±0.02	NOUN
admet-761	109	13	)	)	PUNCT
admet-761	109	14	-5.65(±0.05	-5.65(±0.05	ADJ
admet-761	109	15	)	)	PUNCT
admet-761	109	16	-5.33(±0.07	-5.33(±0.07	NOUN
admet-761	109	17	)	)	PUNCT
admet-761	109	18	-5.20(±0.05	-5.20(±0.05	ADJ
admet-761	109	19	)	)	PUNCT
admet-761	109	20	hydrocortisone	hydrocortisone	NOUN
admet-761	109	21	-7.22	-7.22	NUM
admet-761	109	22	1.61	1.61	NUM
admet-761	109	23	-6.13(±0.03	-6.13(±0.03	ADJ
admet-761	109	24	)	)	PUNCT
admet-761	109	25	-6.04(±0.07	-6.04(±0.07	PROPN
admet-761	109	26	)	)	PUNCT
admet-761	109	27	-6.30(±0.18	-6.30(±0.18	NOUN
admet-761	109	28	)	)	PUNCT
admet-761	109	29	-6.14(±0.08	-6.14(±0.08	ADJ
admet-761	109	30	)	)	PUNCT
admet-761	109	31	ibuprofen	ibuprofen	NOUN
admet-761	109	32	-4.58	-4.58	NUM
admet-761	109	33	3.50	3.50	NUM
admet-761	109	34	4.43	4.43	NUM
admet-761	109	35	d	d	PRON
admet-761	109	36	-2.71(±0.04	-2.71(±0.04	NOUN
admet-761	109	37	)	)	PUNCT
admet-761	109	38	-3.61(±0.05	-3.61(±0.05	NOUN
admet-761	109	39	)	)	PUNCT
admet-761	109	40	-3.59(±0.08	-3.59(±0.08	ADJ
admet-761	109	41	)	)	PUNCT
admet-761	109	42	-3.65(±0.04	-3.65(±0.04	NOUN
admet-761	109	43	)	)	PUNCT
admet-761	109	44	naproxen	naproxen	NOUN
admet-761	109	45	-4.97	-4.97	VERB
admet-761	109	46	3.34	3.34	NUM
admet-761	109	47	4.28	4.28	NUM
admet-761	109	48	e	e	NOUN
admet-761	109	49	-3.96(±0.12	-3.96(±0.12	NOUN
admet-761	109	50	)	)	PUNCT
admet-761	109	51	-4.19(±0.02	-4.19(±0.02	NOUN
admet-761	109	52	)	)	PUNCT
admet-761	109	53	-3.99(±0.08	-3.99(±0.08	NOUN
admet-761	109	54	)	)	PUNCT
admet-761	109	55	-4.24(±0.06	-4.24(±0.06	NOUN
admet-761	109	56	)	)	PUNCT
admet-761	109	57	progesterone	progesterone	NOUN
admet-761	109	58	-4.90	-4.90	NUM
admet-761	109	59	3.87	3.87	NUM
admet-761	109	60	-3.25(±0.25	-3.25(±0.25	NOUN
admet-761	109	61	)	)	PUNCT
admet-761	109	62	-4.11(±0.10	-4.11(±0.10	NOUN
admet-761	109	63	)	)	PUNCT
admet-761	109	64	-4.59(±0.15	-4.59(±0.15	NOUN
admet-761	109	65	)	)	PUNCT
admet-761	109	66	-4.81(±0.06	-4.81(±0.06	NOUN
admet-761	109	67	)	)	PUNCT
admet-761	109	68	-4.88(±0.22	-4.88(±0.22	NOUN
admet-761	109	69	)	)	PUNCT
admet-761	109	70	-4.69(±0.12	-4.69(±0.12	PROPN
admet-761	109	71	)	)	PUNCT
admet-761	110	1	a	a	PRON
admet-761	110	2	from	from	ADP
admet-761	110	3	reference	reference	NOUN
admet-761	110	4	[	[	X
admet-761	110	5	20	20	NUM
admet-761	110	6	]	]	PUNCT
admet-761	110	7	,	,	PUNCT
admet-761	110	8	b	b	X
admet-761	110	9	from	from	ADP
admet-761	110	10	reference	reference	NOUN
admet-761	110	11	[	[	X
admet-761	110	12	19	19	NUM
admet-761	110	13	]	]	PUNCT
admet-761	110	14	,	,	PUNCT
admet-761	110	15	c	c	NOUN
admet-761	110	16	from	from	ADP
admet-761	110	17	reference	reference	NOUN
admet-761	110	18	[	[	X
admet-761	110	19	21	21	NUM
admet-761	110	20	]	]	PUNCT
admet-761	110	21	,	,	PUNCT
admet-761	110	22	d	d	X
admet-761	110	23	from	from	ADP
admet-761	110	24	reference	reference	NOUN
admet-761	110	25	[	[	X
admet-761	110	26	22	22	NUM
admet-761	110	27	]	]	PUNCT
admet-761	110	28	,	,	PUNCT
admet-761	110	29	e	e	X
admet-761	110	30	from	from	ADP
admet-761	110	31	reference	reference	NOUN
admet-761	110	32	[	[	X
admet-761	110	33	23	23	NUM
admet-761	110	34	]	]	X
admet-761	110	35	first	first	ADV
admet-761	110	36	,	,	PUNCT
admet-761	110	37	to	to	PART
admet-761	110	38	study	study	VERB
admet-761	110	39	the	the	DET
admet-761	110	40	effect	effect	NOUN
admet-761	110	41	of	of	ADP
admet-761	110	42	the	the	DET
admet-761	110	43	incubation	incubation	NOUN
admet-761	110	44	time	time	NOUN
admet-761	110	45	and	and	CCONJ
admet-761	110	46	stirring	stirring	NOUN
admet-761	110	47	in	in	ADP
admet-761	110	48	the	the	DET
admet-761	110	49	determination	determination	NOUN
admet-761	110	50	of	of	ADP
admet-761	110	51	the	the	DET
admet-761	110	52	skin	skin	NOUN
admet-761	110	53	permeability	permeability	NOUN
admet-761	110	54	through	through	ADP
admet-761	110	55	the	the	DET
admet-761	110	56	skin	skin	NOUN
admet-761	110	57	-	-	PUNCT
admet-761	110	58	pampa	pampa	NOUN
admet-761	110	59	permeability	permeability	NOUN
admet-761	110	60	,	,	PUNCT
admet-761	110	61	the	the	DET
admet-761	110	62	log	log	NOUN
admet-761	110	63	kp	kp	PROPN
admet-761	110	64	values	value	NOUN
admet-761	110	65	were	be	AUX
admet-761	110	66	correlated	correlate	VERB
admet-761	110	67	to	to	ADP
admet-761	110	68	the	the	DET
admet-761	110	69	log	log	NOUN
admet-761	110	70	pe	pe	PROPN
admet-761	110	71	obtained	obtain	VERB
admet-761	110	72	from	from	ADP
admet-761	110	73	skin	skin	NOUN
admet-761	110	74	-	-	PUNCT
admet-761	110	75	pampa	pampa	NOUN
admet-761	110	76	assays	assay	NOUN
admet-761	110	77	at	at	ADP
admet-761	110	78	each	each	DET
admet-761	110	79	incubation	incubation	NOUN
admet-761	110	80	time	time	NOUN
admet-761	110	81	.	.	PUNCT
admet-761	111	1	the	the	DET
admet-761	111	2	correlations	correlation	NOUN
admet-761	111	3	obtained	obtain	VERB
admet-761	111	4	are	be	AUX
admet-761	111	5	presented	present	VERB
admet-761	111	6	in	in	ADP
admet-761	111	7	figure	figure	NOUN
admet-761	111	8	1	1	NUM
admet-761	111	9	a	a	DET
admet-761	111	10	-	-	PUNCT
admet-761	111	11	c.	c.	NOUN
admet-761	111	12	each	each	DET
admet-761	111	13	figure	figure	NOUN
admet-761	111	14	contains	contain	VERB
admet-761	111	15	two	two	NUM
admet-761	111	16	different	different	ADJ
admet-761	111	17	correlations	correlation	NOUN
admet-761	111	18	,	,	PUNCT
admet-761	111	19	one	one	NUM
admet-761	111	20	for	for	ADP
admet-761	111	21	the	the	DET
admet-761	111	22	stirred	stirred	ADJ
admet-761	111	23	assays	assay	NOUN
admet-761	111	24	and	and	CCONJ
admet-761	111	25	another	another	PRON
admet-761	111	26	for	for	ADP
admet-761	111	27	unstirred	unstirred	ADJ
admet-761	111	28	assays	assay	NOUN
admet-761	111	29	.	.	PUNCT
admet-761	112	1	as	as	SCONJ
admet-761	112	2	it	it	PRON
admet-761	112	3	can	can	AUX
admet-761	112	4	be	be	AUX
admet-761	112	5	observed	observe	VERB
admet-761	112	6	,	,	PUNCT
admet-761	112	7	the	the	DET
admet-761	112	8	number	number	NOUN
admet-761	112	9	of	of	ADP
admet-761	112	10	compounds	compound	NOUN
admet-761	112	11	that	that	PRON
admet-761	112	12	can	can	AUX
admet-761	112	13	be	be	AUX
admet-761	112	14	determined	determine	VERB
admet-761	112	15	in	in	ADP
admet-761	112	16	4	4	NUM
admet-761	112	17	hours	hour	NOUN
admet-761	112	18	(	(	PUNCT
admet-761	112	19	n=8	n=8	NUM
admet-761	112	20	)	)	PUNCT
admet-761	112	21	is	be	AUX
admet-761	112	22	greater	great	ADJ
admet-761	112	23	than	than	ADP
admet-761	112	24	in	in	ADP
admet-761	112	25	30	30	NUM
admet-761	112	26	minutes	minute	NOUN
admet-761	112	27	(	(	PUNCT
admet-761	112	28	n=6	n=6	NOUN
admet-761	112	29	)	)	PUNCT
admet-761	112	30	and	and	CCONJ
admet-761	112	31	24	24	NUM
admet-761	112	32	hours	hour	NOUN
admet-761	112	33	(	(	PUNCT
admet-761	112	34	n=6	n=6	NOUN
admet-761	112	35	)	)	PUNCT
admet-761	112	36	.	.	PUNCT
admet-761	113	1	for	for	ADP
admet-761	113	2	some	some	DET
admet-761	113	3	compounds	compound	NOUN
admet-761	113	4	,	,	PUNCT
admet-761	113	5	such	such	ADJ
admet-761	113	6	as	as	ADP
admet-761	113	7	5	5	NUM
admet-761	113	8	-	-	PUNCT
admet-761	113	9	fluorouracil	fluorouracil	NOUN
admet-761	113	10	,	,	PUNCT
admet-761	113	11	hydrocortisone	hydrocortisone	NOUN
admet-761	113	12	and	and	CCONJ
admet-761	113	13	digitoxin	digitoxin	PROPN
admet-761	113	14	,	,	PUNCT
admet-761	113	15	whose	whose	DET
admet-761	113	16	log	log	NOUN
admet-761	113	17	kp	kp	PROPN
admet-761	113	18	values	value	NOUN
admet-761	113	19	are	be	AUX
admet-761	113	20	quite	quite	ADV
admet-761	113	21	low	low	ADJ
admet-761	113	22	,	,	PUNCT
admet-761	113	23	an	an	DET
admet-761	113	24	incubation	incubation	NOUN
admet-761	113	25	time	time	NOUN
admet-761	113	26	of	of	ADP
admet-761	113	27	30	30	NUM
admet-761	113	28	minutes	minute	NOUN
admet-761	113	29	is	be	AUX
admet-761	113	30	not	not	PART
admet-761	113	31	enough	enough	ADJ
admet-761	113	32	to	to	PART
admet-761	113	33	reach	reach	VERB
admet-761	113	34	the	the	DET
admet-761	113	35	steady	steady	ADJ
admet-761	113	36	state	state	NOUN
admet-761	113	37	,	,	PUNCT
admet-761	113	38	therefore	therefore	ADV
admet-761	113	39	their	their	PRON
admet-761	113	40	skin	skin	NOUN
admet-761	113	41	-	-	PUNCT
admet-761	113	42	pampa	pampa	NOUN
admet-761	113	43	permeability	permeability	NOUN
admet-761	113	44	values	value	NOUN
admet-761	113	45	can	can	AUX
admet-761	113	46	not	not	PART
admet-761	113	47	be	be	AUX
admet-761	113	48	evaluated	evaluate	VERB
admet-761	113	49	.	.	PUNCT
admet-761	114	1	after	after	ADP
admet-761	114	2	4	4	NUM
admet-761	114	3	hours	hour	NOUN
admet-761	114	4	of	of	ADP
admet-761	114	5	incubation	incubation	NOUN
admet-761	114	6	,	,	PUNCT
admet-761	114	7	all	all	DET
admet-761	114	8	drugs	drug	NOUN
admet-761	114	9	can	can	AUX
admet-761	114	10	be	be	AUX
admet-761	114	11	determined	determine	VERB
admet-761	114	12	except	except	SCONJ
admet-761	114	13	digitoxin	digitoxin	PROPN
admet-761	114	14	which	which	PRON
admet-761	114	15	does	do	AUX
admet-761	114	16	not	not	PART
admet-761	114	17	arrive	arrive	VERB
admet-761	114	18	at	at	ADP
admet-761	114	19	the	the	DET
admet-761	114	20	steady	steady	ADJ
admet-761	114	21	state	state	NOUN
admet-761	114	22	.	.	PUNCT
admet-761	115	1	digitoxin	digitoxin	PROPN
admet-761	115	2	is	be	AUX
admet-761	115	3	considered	consider	VERB
admet-761	115	4	very	very	ADV
admet-761	115	5	little	little	ADJ
admet-761	115	6	permeable	permeable	ADJ
admet-761	115	7	due	due	ADP
admet-761	115	8	to	to	ADP
admet-761	115	9	its	its	PRON
admet-761	115	10	very	very	ADV
admet-761	115	11	low	low	ADJ
admet-761	115	12	in	in	ADP
admet-761	115	13	vitro	vitro	X
admet-761	115	14	skin	skin	NOUN
admet-761	115	15	permeability	permeability	NOUN
admet-761	115	16	value	value	NOUN
admet-761	115	17	(	(	PUNCT
admet-761	115	18	log	log	NOUN
admet-761	115	19	kp	kp	X
admet-761	115	20	=	=	PUNCT
admet-761	115	21	-8.15	-8.15	PROPN
admet-761	115	22	)	)	PUNCT
admet-761	115	23	.	.	PUNCT
admet-761	116	1	after	after	ADP
admet-761	116	2	24	24	NUM
admet-761	116	3	hours	hour	NOUN
admet-761	116	4	of	of	ADP
admet-761	116	5	incubation	incubation	NOUN
admet-761	116	6	,	,	PUNCT
admet-761	116	7	digitoxin	digitoxin	PROPN
admet-761	116	8	can	can	AUX
admet-761	116	9	reach	reach	VERB
admet-761	116	10	the	the	DET
admet-761	116	11	steady	steady	ADJ
admet-761	116	12	state	state	NOUN
admet-761	116	13	and	and	CCONJ
admet-761	116	14	its	its	PRON
admet-761	116	15	skin	skin	NOUN
admet-761	116	16	-	-	PUNCT
admet-761	116	17	pampa	pampa	NOUN
admet-761	116	18	permeability	permeability	NOUN
admet-761	116	19	values	value	NOUN
admet-761	116	20	can	can	AUX
admet-761	116	21	be	be	AUX
admet-761	116	22	determined	determine	VERB
admet-761	116	23	.	.	PUNCT
admet-761	117	1	however	however	ADV
admet-761	117	2	,	,	PUNCT
admet-761	117	3	compounds	compound	VERB
admet-761	117	4	such	such	ADJ
admet-761	117	5	as	as	ADP
admet-761	117	6	flurbiprofen	flurbiprofen	NOUN
admet-761	117	7	,	,	PUNCT
admet-761	117	8	ibuprofen	ibuprofen	NOUN
admet-761	117	9	and	and	CCONJ
admet-761	117	10	naproxen	naproxen	PROPN
admet-761	117	11	(	(	PUNCT
admet-761	117	12	with	with	ADP
admet-761	117	13	high	high	ADJ
admet-761	117	14	log	log	NOUN
admet-761	117	15	kp	kp	PROPN
admet-761	117	16	values	value	NOUN
admet-761	117	17	)	)	PUNCT
admet-761	117	18	can	can	AUX
admet-761	117	19	not	not	PART
admet-761	117	20	be	be	AUX
admet-761	117	21	determined	determine	VERB
admet-761	117	22	.	.	PUNCT
admet-761	118	1	when	when	SCONJ
admet-761	118	2	a	a	DET
admet-761	118	3	compound	compound	NOUN
admet-761	118	4	is	be	AUX
admet-761	118	5	highly	highly	ADV
admet-761	118	6	permeable	permeable	ADJ
admet-761	118	7	,	,	PUNCT
admet-761	118	8	long	long	ADJ
admet-761	118	9	incubation	incubation	NOUN
admet-761	118	10	times	time	NOUN
admet-761	118	11	under	under	ADP
admet-761	118	12	gradient	gradient	NOUN
admet-761	118	13	-	-	PUNCT
admet-761	118	14	ph	ph	NOUN
admet-761	118	15	conditions	condition	NOUN
admet-761	118	16	provoke	provoke	VERB
admet-761	118	17	that	that	SCONJ
admet-761	118	18	the	the	DET
admet-761	118	19	donor	donor	NOUN
admet-761	118	20	and	and	CCONJ
admet-761	118	21	acceptor	acceptor	NOUN
admet-761	118	22	compartment	compartment	NOUN
admet-761	118	23	concentrations	concentration	NOUN
admet-761	118	24	achieve	achieve	VERB
admet-761	118	25	equilibrium	equilibrium	NOUN
admet-761	118	26	values	value	NOUN
admet-761	118	27	and	and	CCONJ
admet-761	118	28	hence	hence	ADV
admet-761	118	29	the	the	DET
admet-761	118	30	whole	whole	ADJ
admet-761	118	31	sample	sample	NOUN
admet-761	118	32	of	of	ADP
admet-761	118	33	the	the	DET
admet-761	118	34	donor	donor	NOUN
admet-761	118	35	compartment	compartment	NOUN
admet-761	118	36	moves	move	NOUN
admet-761	118	37	to	to	PART
admet-761	118	38	acceptor	acceptor	NOUN
admet-761	118	39	compartment	compartment	NOUN
admet-761	118	40	due	due	ADJ
admet-761	118	41	to	to	ADP
admet-761	118	42	sink	sink	VERB
admet-761	118	43	conditions	condition	NOUN
admet-761	118	44	,	,	PUNCT
admet-761	118	45	making	make	VERB
admet-761	118	46	difficult	difficult	ADJ
admet-761	118	47	to	to	PART
admet-761	118	48	determine	determine	VERB
admet-761	118	49	the	the	DET
admet-761	118	50	permeability	permeability	NOUN
admet-761	118	51	values	value	NOUN
admet-761	118	52	.	.	PUNCT
admet-761	119	1	figure	figure	NOUN
admet-761	119	2	1	1	NUM
admet-761	119	3	.	.	PUNCT
admet-761	119	4	effect	effect	NOUN
admet-761	119	5	of	of	ADP
admet-761	119	6	incubation	incubation	NOUN
admet-761	119	7	time	time	NOUN
admet-761	119	8	and	and	CCONJ
admet-761	119	9	stirring	stirring	NOUN
admet-761	119	10	in	in	ADP
admet-761	119	11	the	the	DET
admet-761	119	12	determination	determination	NOUN
admet-761	119	13	of	of	ADP
admet-761	119	14	the	the	DET
admet-761	119	15	skin	skin	NOUN
admet-761	119	16	permeability	permeability	NOUN
admet-761	119	17	(	(	PUNCT
admet-761	119	18	log	log	NOUN
admet-761	119	19	kp	kp	NOUN
admet-761	119	20	)	)	PUNCT
admet-761	119	21	through	through	ADP
admet-761	119	22	the	the	DET
admet-761	119	23	skin	skin	NOUN
admet-761	119	24	-	-	PUNCT
admet-761	119	25	pampa	pampa	NOUN
admet-761	119	26	permeability	permeability	NOUN
admet-761	119	27	(	(	PUNCT
admet-761	119	28	log	log	NOUN
admet-761	119	29	pe	pe	INTJ
admet-761	119	30	)	)	PUNCT
admet-761	119	31	.	.	PUNCT
admet-761	120	1	incubation	incubation	NOUN
admet-761	120	2	time	time	NOUN
admet-761	120	3	:	:	PUNCT
admet-761	120	4	30	30	NUM
admet-761	120	5	minutes	minute	NOUN
admet-761	120	6	(	(	PUNCT
admet-761	120	7	a	a	X
admet-761	120	8	)	)	PUNCT
admet-761	120	9	;	;	PUNCT
admet-761	120	10	4	4	NUM
admet-761	120	11	hours	hour	NOUN
admet-761	120	12	(	(	PUNCT
admet-761	120	13	b	b	NOUN
admet-761	120	14	)	)	PUNCT
admet-761	120	15	;	;	PUNCT
admet-761	120	16	24	24	NUM
admet-761	120	17	hours	hour	NOUN
admet-761	120	18	(	(	PUNCT
admet-761	120	19	c	c	NOUN
admet-761	120	20	)	)	PUNCT
admet-761	120	21	;	;	PUNCT
admet-761	120	22	stirred	stir	VERB
admet-761	120	23	assay	assay	PROPN
admet-761	120	24	(	(	PUNCT
admet-761	120	25	●	●	NOUN
admet-761	120	26	)	)	PUNCT
admet-761	120	27	;	;	PUNCT
admet-761	120	28	non	non	ADJ
admet-761	120	29	-	-	ADJ
admet-761	120	30	stirred	stirred	ADJ
admet-761	120	31	assay	assay	PROPN
admet-761	120	32	(	(	PUNCT
admet-761	120	33	⨉	⨉	PROPN
admet-761	120	34	)	)	PUNCT
admet-761	120	35	.	.	PUNCT
admet-761	121	1	relative	relative	ADJ
admet-761	121	2	to	to	ADP
admet-761	121	3	stirring	stir	VERB
admet-761	121	4	and	and	CCONJ
admet-761	121	5	non	non	ADJ
admet-761	121	6	-	-	ADJ
admet-761	121	7	stirring	stirring	ADJ
admet-761	121	8	experiments	experiment	NOUN
admet-761	121	9	,	,	PUNCT
admet-761	121	10	table	table	NOUN
admet-761	121	11	1	1	NUM
admet-761	121	12	shows	show	VERB
admet-761	121	13	the	the	DET
admet-761	121	14	results	result	NOUN
admet-761	121	15	obtained	obtain	VERB
admet-761	121	16	at	at	ADP
admet-761	121	17	different	different	ADJ
admet-761	121	18	incubation	incubation	NOUN
admet-761	121	19	times	time	NOUN
admet-761	121	20	.	.	PUNCT
admet-761	122	1	at	at	ADP
admet-761	122	2	30	30	NUM
admet-761	122	3	minutes	minute	NOUN
admet-761	122	4	of	of	ADP
admet-761	122	5	incubation	incubation	NOUN
admet-761	122	6	time	time	NOUN
admet-761	122	7	flurbiprofen	flurbiprofen	NOUN
admet-761	122	8	,	,	PUNCT
admet-761	122	9	progesterone	progesterone	NOUN
admet-761	122	10	and	and	CCONJ
admet-761	122	11	ibuprofen	ibuprofen	NOUN
admet-761	122	12	show	show	NOUN
admet-761	122	13	great	great	ADJ
admet-761	122	14	log	log	NOUN
admet-761	122	15	pe	pe	INTJ
admet-761	122	16	values	value	NOUN
admet-761	122	17	in	in	ADP
admet-761	122	18	stirred	stir	VERB
admet-761	122	19	assays	assay	NOUN
admet-761	122	20	compared	compare	VERB
admet-761	122	21	to	to	ADP
admet-761	122	22	unstirred	unstirred	ADJ
admet-761	122	23	ones	one	NOUN
admet-761	122	24	.	.	PUNCT
admet-761	123	1	this	this	DET
admet-761	123	2	difference	difference	NOUN
admet-761	123	3	can	can	AUX
admet-761	123	4	be	be	AUX
admet-761	123	5	attributed	attribute	VERB
admet-761	123	6	to	to	ADP
admet-761	123	7	the	the	DET
admet-761	123	8	presence	presence	NOUN
admet-761	123	9	of	of	ADP
admet-761	123	10	uwl	uwl	NOUN
admet-761	123	11	due	due	ADP
admet-761	123	12	to	to	ADP
admet-761	123	13	the	the	DET
admet-761	123	14	lipophilic	lipophilic	ADJ
admet-761	123	15	character	character	NOUN
admet-761	123	16	of	of	ADP
admet-761	123	17	the	the	DET
admet-761	123	18	compounds	compound	NOUN
admet-761	123	19	(	(	PUNCT
admet-761	123	20	log	log	VERB
admet-761	123	21	po	po	NOUN
admet-761	123	22	/	/	SYM
admet-761	123	23	w	w	NOUN
admet-761	123	24	>	>	X
admet-761	123	25	3	3	NUM
admet-761	123	26	)	)	PUNCT
admet-761	123	27	.	.	PUNCT
admet-761	124	1	in	in	ADP
admet-761	124	2	this	this	DET
admet-761	124	3	case	case	NOUN
admet-761	124	4	,	,	PUNCT
admet-761	124	5	uwl	uwl	PRON
admet-761	124	6	acts	act	VERB
admet-761	124	7	as	as	ADP
admet-761	124	8	rate	rate	NOUN
admet-761	124	9	-	-	PUNCT
admet-761	124	10	limiting	limit	VERB
admet-761	124	11	transport	transport	NOUN
admet-761	124	12	giving	give	VERB
admet-761	124	13	smaller	small	ADJ
admet-761	124	14	permeability	permeability	NOUN
admet-761	124	15	values	value	NOUN
admet-761	124	16	.	.	PUNCT
admet-761	125	1	at	at	ADP
admet-761	125	2	4	4	NUM
admet-761	125	3	hours	hour	NOUN
admet-761	125	4	of	of	ADP
admet-761	125	5	incubation	incubation	NOUN
admet-761	125	6	,	,	PUNCT
admet-761	125	7	log	log	NOUN
admet-761	125	8	pe	pe	PROPN
admet-761	125	9	values	value	NOUN
admet-761	125	10	obtained	obtain	VERB
admet-761	125	11	from	from	ADP
admet-761	125	12	experiments	experiment	NOUN
admet-761	125	13	with	with	ADP
admet-761	125	14	and	and	CCONJ
admet-761	125	15	without	without	ADP
admet-761	125	16	stirring	stirring	NOUN
admet-761	125	17	are	be	AUX
admet-761	125	18	almost	almost	ADV
admet-761	125	19	the	the	DET
admet-761	125	20	same	same	ADJ
admet-761	125	21	except	except	SCONJ
admet-761	125	22	for	for	ADP
admet-761	125	23	progesterone	progesterone	NOUN
admet-761	125	24	(	(	PUNCT
admet-761	125	25	log	log	VERB
admet-761	125	26	pe	pe	PRON
admet-761	125	27	equal	equal	ADJ
admet-761	125	28	to	to	ADP
admet-761	125	29	–	–	PUNCT
admet-761	125	30	4.11	4.11	NUM
admet-761	125	31	and	and	CCONJ
admet-761	125	32	-4.88	-4.88	ADJ
admet-761	125	33	,	,	PUNCT
admet-761	125	34	respectively	respectively	ADV
admet-761	125	35	)	)	PUNCT
admet-761	125	36	and	and	CCONJ
admet-761	125	37	5	5	NUM
admet-761	125	38	-	-	PUNCT
admet-761	125	39	fluorouracil	fluorouracil	NOUN
admet-761	125	40	(	(	PUNCT
admet-761	125	41	log	log	VERB
admet-761	125	42	pe	pe	PRON
admet-761	125	43	equal	equal	ADJ
admet-761	125	44	to	to	ADP
admet-761	125	45	5.77	5.77	NUM
admet-761	125	46	and	and	CCONJ
admet-761	125	47	-6.47	-6.47	NOUN
admet-761	125	48	,	,	PUNCT
admet-761	125	49	respectively	respectively	ADV
admet-761	125	50	)	)	PUNCT
admet-761	125	51	.	.	PUNCT
admet-761	126	1	for	for	ADP
admet-761	126	2	progesterone	progesterone	NOUN
admet-761	126	3	,	,	PUNCT
admet-761	126	4	this	this	DET
admet-761	126	5	difference	difference	NOUN
admet-761	126	6	can	can	AUX
admet-761	126	7	be	be	AUX
admet-761	126	8	justified	justify	VERB
admet-761	126	9	by	by	ADP
admet-761	126	10	the	the	DET
admet-761	126	11	presence	presence	NOUN
admet-761	126	12	of	of	ADP
admet-761	126	13	uwl	uwl	NOUN
admet-761	126	14	or	or	CCONJ
admet-761	126	15	the	the	DET
admet-761	126	16	high	high	ADJ
admet-761	126	17	membrane	membrane	NOUN
admet-761	126	18	retention	retention	NOUN
admet-761	126	19	values	value	NOUN
admet-761	126	20	.	.	PUNCT
admet-761	127	1	the	the	DET
admet-761	127	2	reason	reason	NOUN
admet-761	127	3	for	for	ADP
admet-761	127	4	5	5	NUM
admet-761	127	5	-	-	PUNCT
admet-761	127	6	fluorouracil	fluorouracil	NOUN
admet-761	127	7	is	be	AUX
admet-761	127	8	unknown	unknown	ADJ
admet-761	127	9	since	since	SCONJ
admet-761	127	10	it	it	PRON
admet-761	127	11	is	be	AUX
admet-761	127	12	a	a	DET
admet-761	127	13	very	very	ADV
admet-761	127	14	hydrophilic	hydrophilic	ADJ
admet-761	127	15	compound	compound	NOUN
admet-761	127	16	and	and	CCONJ
admet-761	127	17	therefore	therefore	ADV
admet-761	127	18	the	the	DET
admet-761	127	19	difference	difference	NOUN
admet-761	127	20	of	of	ADP
admet-761	127	21	values	value	NOUN
admet-761	127	22	can	can	AUX
admet-761	127	23	not	not	PART
admet-761	127	24	be	be	AUX
admet-761	127	25	attributed	attribute	VERB
admet-761	127	26	to	to	ADP
admet-761	127	27	uwl	uwl	ADV
admet-761	127	28	effect	effect	VERB
admet-761	127	29	.	.	PUNCT
admet-761	128	1	in	in	ADP
admet-761	128	2	general	general	ADJ
admet-761	128	3	,	,	PUNCT
admet-761	128	4	it	it	PRON
admet-761	128	5	seems	seem	VERB
admet-761	128	6	that	that	SCONJ
admet-761	128	7	with	with	ADP
admet-761	128	8	4	4	NUM
admet-761	128	9	hours	hour	NOUN
admet-761	128	10	of	of	ADP
admet-761	128	11	incubation	incubation	NOUN
admet-761	128	12	time	time	NOUN
admet-761	128	13	the	the	DET
admet-761	128	14	aqueous	aqueous	ADJ
admet-761	128	15	boundary	boundary	ADJ
admet-761	128	16	layer	layer	NOUN
admet-761	128	17	does	do	AUX
admet-761	128	18	not	not	PART
admet-761	128	19	have	have	VERB
admet-761	128	20	much	much	ADJ
admet-761	128	21	effect	effect	NOUN
admet-761	128	22	in	in	ADP
admet-761	128	23	most	most	ADJ
admet-761	128	24	compounds	compound	NOUN
admet-761	128	25	.	.	PUNCT
admet-761	129	1	at	at	ADP
admet-761	129	2	24	24	NUM
admet-761	129	3	hours	hour	NOUN
admet-761	129	4	,	,	PUNCT
admet-761	129	5	apart	apart	ADV
admet-761	129	6	from	from	ADP
admet-761	129	7	flurbiprofen	flurbiprofen	NOUN
admet-761	129	8	,	,	PUNCT
admet-761	129	9	ibuprofen	ibuprofen	NOUN
admet-761	129	10	,	,	PUNCT
admet-761	129	11	and	and	CCONJ
admet-761	129	12	naproxen	naproxen	NOUN
admet-761	129	13	which	which	PRON
admet-761	129	14	could	could	AUX
admet-761	129	15	n’t	not	PART
admet-761	129	16	be	be	AUX
admet-761	129	17	evaluated	evaluate	VERB
admet-761	129	18	,	,	PUNCT
admet-761	129	19	the	the	DET
admet-761	129	20	results	result	NOUN
admet-761	129	21	obtained	obtain	VERB
admet-761	129	22	with	with	ADP
admet-761	129	23	and	and	CCONJ
admet-761	129	24	without	without	ADP
admet-761	129	25	stirring	stirring	NOUN
admet-761	129	26	are	be	AUX
admet-761	129	27	practically	practically	ADV
admet-761	129	28	the	the	DET
admet-761	129	29	same	same	ADJ
admet-761	129	30	.	.	PUNCT
admet-761	130	1	the	the	DET
admet-761	130	2	membrane	membrane	NOUN
admet-761	130	3	retention	retention	NOUN
admet-761	130	4	values	value	NOUN
admet-761	130	5	can	can	AUX
admet-761	130	6	sometimes	sometimes	ADV
admet-761	130	7	be	be	AUX
admet-761	130	8	very	very	ADV
admet-761	130	9	high	high	ADJ
admet-761	130	10	depending	depend	VERB
admet-761	130	11	on	on	ADP
admet-761	130	12	the	the	DET
admet-761	130	13	composition	composition	NOUN
admet-761	130	14	of	of	ADP
admet-761	130	15	the	the	DET
admet-761	130	16	pampa	pampa	NOUN
admet-761	130	17	membrane	membrane	NOUN
admet-761	130	18	.	.	PUNCT
admet-761	131	1	for	for	ADP
admet-761	131	2	example	example	NOUN
admet-761	131	3	,	,	PUNCT
admet-761	131	4	membranes	membrane	NOUN
admet-761	131	5	made	make	VERB
admet-761	131	6	of	of	ADP
admet-761	131	7	2	2	NUM
admet-761	131	8	%	%	NOUN
admet-761	131	9	dopc	dopc	NOUN
admet-761	131	10	(	(	PUNCT
admet-761	131	11	dioleoylphosphatidylcholine	dioleoylphosphatidylcholine	NOUN
admet-761	131	12	)	)	PUNCT
admet-761	131	13	dissolved	dissolve	VERB
admet-761	131	14	in	in	ADP
admet-761	131	15	dodecane	dodecane	NOUN
admet-761	131	16	can	can	AUX
admet-761	131	17	have	have	VERB
admet-761	131	18	rm	rm	NOUN
admet-761	131	19	values	value	NOUN
admet-761	131	20	higher	high	ADJ
admet-761	131	21	than	than	ADP
admet-761	131	22	0.80	0.80	NUM
admet-761	131	23	[	[	NOUN
admet-761	131	24	4	4	NUM
admet-761	131	25	]	]	PUNCT
admet-761	131	26	.	.	PUNCT
admet-761	132	1	in	in	ADP
admet-761	132	2	the	the	DET
admet-761	132	3	case	case	NOUN
admet-761	132	4	of	of	ADP
admet-761	132	5	the	the	DET
admet-761	132	6	skin	skin	NOUN
admet-761	132	7	-	-	PUNCT
admet-761	132	8	pampa	pampa	NOUN
admet-761	132	9	membrane	membrane	NOUN
admet-761	132	10	,	,	PUNCT
admet-761	132	11	retention	retention	NOUN
admet-761	132	12	is	be	AUX
admet-761	132	13	in	in	ADP
admet-761	132	14	general	general	ADJ
admet-761	132	15	low	low	NOUN
admet-761	132	16	and	and	CCONJ
admet-761	132	17	goes	go	VERB
admet-761	132	18	from	from	ADP
admet-761	132	19	0	0	NUM
admet-761	132	20	to	to	ADP
admet-761	132	21	0.30	0.30	NUM
admet-761	132	22	for	for	ADP
admet-761	132	23	most	most	ADJ
admet-761	132	24	of	of	ADP
admet-761	132	25	the	the	DET
admet-761	132	26	analyzed	analyze	VERB
admet-761	132	27	compounds	compound	NOUN
admet-761	132	28	(	(	PUNCT
admet-761	132	29	see	see	VERB
admet-761	132	30	table	table	NOUN
admet-761	132	31	2	2	NUM
admet-761	132	32	)	)	PUNCT
admet-761	132	33	,	,	PUNCT
admet-761	132	34	except	except	SCONJ
admet-761	132	35	for	for	ADP
admet-761	132	36	progesterone	progesterone	NOUN
admet-761	132	37	whose	whose	DET
admet-761	132	38	values	value	NOUN
admet-761	132	39	are	be	AUX
admet-761	132	40	very	very	ADV
admet-761	132	41	high	high	ADJ
admet-761	132	42	(	(	PUNCT
admet-761	132	43	0.33	0.33	NUM
admet-761	132	44	-	-	SYM
admet-761	132	45	0.88	0.88	NUM
admet-761	132	46	)	)	PUNCT
admet-761	132	47	.	.	PUNCT
admet-761	133	1	for	for	ADP
admet-761	133	2	some	some	DET
admet-761	133	3	compounds	compound	NOUN
admet-761	133	4	this	this	DET
admet-761	133	5	parameter	parameter	NOUN
admet-761	133	6	can	can	AUX
admet-761	133	7	depend	depend	VERB
admet-761	133	8	on	on	ADP
admet-761	133	9	the	the	DET
admet-761	133	10	incubation	incubation	NOUN
admet-761	133	11	time	time	NOUN
admet-761	133	12	.	.	PUNCT
admet-761	134	1	for	for	ADP
admet-761	134	2	5	5	NUM
admet-761	134	3	-	-	PUNCT
admet-761	134	4	fluorouracil	fluorouracil	NOUN
admet-761	134	5	,	,	PUNCT
admet-761	134	6	aminopyrine	aminopyrine	NOUN
admet-761	134	7	,	,	PUNCT
admet-761	134	8	and	and	CCONJ
admet-761	134	9	hydrocortisone	hydrocortisone	NOUN
admet-761	134	10	this	this	DET
admet-761	134	11	parameter	parameter	NOUN
admet-761	134	12	is	be	AUX
admet-761	134	13	almost	almost	ADV
admet-761	134	14	null	null	ADJ
admet-761	134	15	;	;	PUNCT
admet-761	134	16	minimum	minimum	ADJ
admet-761	134	17	retention	retention	NOUN
admet-761	134	18	is	be	AUX
admet-761	134	19	observed	observe	VERB
admet-761	134	20	only	only	ADV
admet-761	134	21	after	after	ADP
admet-761	134	22	24	24	NUM
admet-761	134	23	h	h	NOUN
admet-761	134	24	of	of	ADP
admet-761	134	25	incubation	incubation	NOUN
admet-761	134	26	.	.	PUNCT
admet-761	135	1	note	note	VERB
admet-761	135	2	that	that	SCONJ
admet-761	135	3	these	these	DET
admet-761	135	4	compounds	compound	NOUN
admet-761	135	5	are	be	AUX
admet-761	135	6	quite	quite	ADV
admet-761	135	7	hydrophilic	hydrophilic	ADJ
admet-761	135	8	and	and	CCONJ
admet-761	135	9	are	be	AUX
admet-761	135	10	almost	almost	ADV
admet-761	135	11	neutral	neutral	ADJ
admet-761	135	12	at	at	ADP
admet-761	135	13	the	the	DET
admet-761	135	14	ph	ph	NOUN
admet-761	135	15	of	of	ADP
admet-761	135	16	the	the	DET
admet-761	135	17	determination	determination	NOUN
admet-761	135	18	.	.	PUNCT
admet-761	136	1	instead	instead	ADV
admet-761	136	2	,	,	PUNCT
admet-761	136	3	for	for	ADP
admet-761	136	4	some	some	DET
admet-761	136	5	other	other	ADJ
admet-761	136	6	compounds	compound	NOUN
admet-761	136	7	such	such	ADJ
admet-761	136	8	as	as	ADP
admet-761	136	9	digitoxin	digitoxin	PROPN
admet-761	136	10	,	,	PUNCT
admet-761	136	11	griseofulvin	griseofulvin	NOUN
admet-761	136	12	and	and	CCONJ
admet-761	136	13	progesterone	progesterone	NOUN
admet-761	136	14	(	(	PUNCT
admet-761	136	15	all	all	DET
admet-761	136	16	neutral	neutral	ADJ
admet-761	136	17	compounds	compound	NOUN
admet-761	136	18	but	but	CCONJ
admet-761	136	19	with	with	ADP
admet-761	136	20	higher	high	ADJ
admet-761	136	21	log	log	NOUN
admet-761	136	22	po	po	NOUN
admet-761	136	23	/	/	SYM
admet-761	136	24	w	w	NOUN
admet-761	136	25	values	value	NOUN
admet-761	136	26	)	)	PUNCT
admet-761	136	27	rm	rm	PROPN
admet-761	136	28	clearly	clearly	ADV
admet-761	136	29	increases	increase	VERB
admet-761	136	30	with	with	ADP
admet-761	136	31	incubation	incubation	NOUN
admet-761	136	32	time	time	NOUN
admet-761	136	33	.	.	PUNCT
admet-761	137	1	in	in	ADP
admet-761	137	2	the	the	DET
admet-761	137	3	case	case	NOUN
admet-761	137	4	of	of	ADP
admet-761	137	5	flurbiprofen	flurbiprofen	NOUN
admet-761	137	6	,	,	PUNCT
admet-761	137	7	ibuprofen	ibuprofen	NOUN
admet-761	137	8	and	and	CCONJ
admet-761	137	9	naproxen	naproxen	PROPN
admet-761	137	10	,	,	PUNCT
admet-761	137	11	rm	rm	PROPN
admet-761	137	12	decreases	decrease	VERB
admet-761	137	13	as	as	ADP
admet-761	137	14	the	the	DET
admet-761	137	15	incubation	incubation	NOUN
admet-761	137	16	time	time	NOUN
admet-761	137	17	increases	increase	NOUN
admet-761	137	18	.	.	PUNCT
admet-761	138	1	these	these	DET
admet-761	138	2	compounds	compound	NOUN
admet-761	138	3	are	be	AUX
admet-761	138	4	completely	completely	ADV
admet-761	138	5	ionized	ionized	ADJ
admet-761	138	6	at	at	ADP
admet-761	138	7	the	the	DET
admet-761	138	8	ph	ph	NOUN
admet-761	138	9	of	of	ADP
admet-761	138	10	the	the	DET
admet-761	138	11	acceptor	acceptor	NOUN
admet-761	138	12	compartment	compartment	NOUN
admet-761	138	13	,	,	PUNCT
admet-761	138	14	and	and	CCONJ
admet-761	138	15	after	after	ADP
admet-761	138	16	some	some	DET
admet-761	138	17	time	time	NOUN
admet-761	138	18	they	they	PRON
admet-761	138	19	are	be	AUX
admet-761	138	20	all	all	ADV
admet-761	138	21	accumulated	accumulate	VERB
admet-761	138	22	in	in	ADP
admet-761	138	23	there	there	ADV
admet-761	138	24	,	,	PUNCT
admet-761	138	25	showing	show	VERB
admet-761	138	26	negligible	negligible	ADJ
admet-761	138	27	retention	retention	NOUN
admet-761	138	28	in	in	ADP
admet-761	138	29	the	the	DET
admet-761	138	30	membrane	membrane	NOUN
admet-761	138	31	.	.	PUNCT
admet-761	139	1	in	in	ADP
admet-761	139	2	general	general	ADJ
admet-761	139	3	terms	term	NOUN
admet-761	139	4	,	,	PUNCT
admet-761	139	5	this	this	DET
admet-761	139	6	factor	factor	NOUN
admet-761	139	7	is	be	AUX
admet-761	139	8	independent	independent	ADJ
admet-761	139	9	of	of	ADP
admet-761	139	10	stirring	stirring	NOUN
admet-761	139	11	or	or	CCONJ
admet-761	139	12	not	not	PART
admet-761	139	13	the	the	DET
admet-761	139	14	solutions	solution	NOUN
admet-761	139	15	as	as	SCONJ
admet-761	139	16	observed	observe	VERB
admet-761	139	17	for	for	ADP
admet-761	139	18	all	all	DET
admet-761	139	19	compounds	compound	NOUN
admet-761	139	20	except	except	SCONJ
admet-761	139	21	for	for	ADP
admet-761	139	22	progesterone	progesterone	NOUN
admet-761	139	23	,	,	PUNCT
admet-761	139	24	which	which	DET
admet-761	139	25	retention	retention	NOUN
admet-761	139	26	factor	factor	NOUN
admet-761	139	27	increases	increase	VERB
admet-761	139	28	with	with	ADP
admet-761	139	29	the	the	DET
admet-761	139	30	stirring	stir	VERB
admet-761	139	31	use	use	NOUN
admet-761	139	32	.	.	PUNCT
admet-761	140	1	table	table	NOUN
admet-761	140	2	2	2	NUM
admet-761	140	3	.	.	PUNCT
admet-761	140	4	membrane	membrane	NOUN
admet-761	140	5	retention	retention	NOUN
admet-761	140	6	values	value	NOUN
admet-761	140	7	of	of	ADP
admet-761	140	8	the	the	DET
admet-761	140	9	neutral	neutral	ADJ
admet-761	140	10	form	form	NOUN
admet-761	140	11	of	of	ADP
admet-761	140	12	the	the	DET
admet-761	140	13	drugs	drug	NOUN
admet-761	140	14	,	,	PUNCT
admet-761	140	15	obtained	obtain	VERB
admet-761	140	16	from	from	ADP
admet-761	140	17	skin	skin	NOUN
admet-761	140	18	-	-	PUNCT
admet-761	140	19	pampa	pampa	NOUN
admet-761	140	20	assays	assay	NOUN
admet-761	140	21	with	with	ADP
admet-761	140	22	and	and	CCONJ
admet-761	140	23	without	without	ADP
admet-761	140	24	stirring	stir	VERB
admet-761	140	25	at	at	ADP
admet-761	140	26	different	different	ADJ
admet-761	140	27	incubation	incubation	NOUN
admet-761	140	28	times	time	NOUN
admet-761	140	29	.	.	PUNCT
admet-761	141	1	rm	rm	NOUN
admet-761	141	2	with	with	ADP
admet-761	141	3	stirring	stir	VERB
admet-761	141	4	without	without	ADP
admet-761	141	5	stirring	stir	VERB
admet-761	141	6	solutes	solute	NOUN
admet-761	141	7	log	log	VERB
admet-761	141	8	kp	kp	PROPN
admet-761	142	1	[	[	X
admet-761	142	2	18	18	NUM
admet-761	142	3	]	]	X
admet-761	142	4	log	log	NOUN
admet-761	142	5	po	po	NOUN
admet-761	142	6	/	/	SYM
admet-761	142	7	w	w	PROPN
admet-761	143	1	[	[	X
admet-761	143	2	19	19	NUM
admet-761	143	3	]	]	X
admet-761	143	4	pka	pka	X
admet-761	143	5	30	30	NUM
admet-761	143	6	min	min	NOUN
admet-761	143	7	4	4	NUM
admet-761	143	8	h	h	NOUN
admet-761	143	9	24	24	NUM
admet-761	143	10	h	h	NOUN
admet-761	143	11	30	30	NUM
admet-761	143	12	min	min	NOUN
admet-761	143	13	4	4	NUM
admet-761	143	14	h	h	NOUN
admet-761	143	15	24	24	NUM
admet-761	143	16	h	h	NOUN
admet-761	143	17	5	5	NUM
admet-761	143	18	-	-	PUNCT
admet-761	143	19	fluorouracil	fluorouracil	NOUN
admet-761	143	20	-6.82	-6.82	NUM
admet-761	143	21	-0.89	-0.89	NUM
admet-761	143	22	7.86	7.86	NUM
admet-761	143	23	a	a	DET
admet-761	143	24	0.00	0.00	NUM
admet-761	143	25	0.04(±0.04	0.04(±0.04	NOUN
admet-761	143	26	)	)	PUNCT
admet-761	143	27	0.08(±0.03	0.08(±0.03	NOUN
admet-761	143	28	)	)	PUNCT
admet-761	143	29	0.00	0.00	NUM
admet-761	143	30	0.01(±0.03	0.01(±0.03	NOUN
admet-761	143	31	)	)	PUNCT
admet-761	143	32	0.05(±0.02	0.05(±0.02	NOUN
admet-761	143	33	)	)	PUNCT
admet-761	143	34	aminopyrine	aminopyrine	NOUN
admet-761	143	35	-6.55	-6.55	NUM
admet-761	143	36	0.80	0.80	NUM
admet-761	143	37	5.00	5.00	NUM
admet-761	143	38	b	b	NOUN
admet-761	143	39	0.00	0.00	NUM
admet-761	143	40	0.00	0.00	NUM
admet-761	143	41	0.05(±0.02	0.05(±0.02	NUM
admet-761	143	42	)	)	PUNCT
admet-761	143	43	0.00	0.00	NUM
admet-761	143	44	0.04(±0.01	0.04(±0.01	NOUN
admet-761	143	45	)	)	PUNCT
admet-761	143	46	0.05(±0.02	0.05(±0.02	PROPN
admet-761	143	47	)	)	PUNCT
admet-761	143	48	digitoxin	digitoxin	PROPN
admet-761	143	49	-8.15	-8.15	NUM
admet-761	143	50	2.83	2.83	NUM
admet-761	143	51	0.00	0.00	NUM
admet-761	143	52	0.22(±0.04	0.22(±0.04	NOUN
admet-761	143	53	)	)	PUNCT
admet-761	143	54	0.29(±0.05	0.29(±0.05	NOUN
admet-761	143	55	)	)	PUNCT
admet-761	143	56	0.00	0.00	NUM
admet-761	143	57	0.09(±0.03	0.09(±0.03	NOUN
admet-761	143	58	)	)	PUNCT
admet-761	143	59	0.25(±0.02	0.25(±0.02	NOUN
admet-761	143	60	)	)	PUNCT
admet-761	143	61	flurbiprofen	flurbiprofen	NOUN
admet-761	143	62	-4.72	-4.72	NOUN
admet-761	143	63	4.16	4.16	NUM
admet-761	143	64	4.19	4.19	NUM
admet-761	143	65	c	c	NOUN
admet-761	143	66	0.18(±0.03	0.18(±0.03	NOUN
admet-761	143	67	)	)	PUNCT
admet-761	143	68	0.00	0.00	NUM
admet-761	143	69	0.00	0.00	NUM
admet-761	143	70	0.13(±0.02	0.13(±0.02	NUM
admet-761	143	71	)	)	PUNCT
admet-761	143	72	0.00	0.00	NUM
admet-761	143	73	0.00	0.00	NUM
admet-761	143	74	griseofulvin	griseofulvin	NOUN
admet-761	143	75	-6.44	-6.44	NUM
admet-761	143	76	2.18	2.18	NUM
admet-761	143	77	0.06(±0.01	0.06(±0.01	NOUN
admet-761	143	78	)	)	PUNCT
admet-761	143	79	0.19(±0.01	0.19(±0.01	NUM
admet-761	143	80	)	)	PUNCT
admet-761	143	81	0.24(±0.02	0.24(±0.02	PROPN
admet-761	143	82	)	)	PUNCT
admet-761	143	83	0.03(±0.02	0.03(±0.02	NOUN
admet-761	143	84	)	)	PUNCT
admet-761	143	85	0.16(±0.01	0.16(±0.01	PROPN
admet-761	143	86	)	)	PUNCT
admet-761	143	87	0.20(±0.02	0.20(±0.02	NOUN
admet-761	143	88	)	)	PUNCT
admet-761	144	1	hydrocortisone	hydrocortisone	PROPN
admet-761	144	2	-7.22	-7.22	NUM
admet-761	144	3	1.61	1.61	NUM
admet-761	144	4	0.02(±0.00	0.02(±0.00	NUM
admet-761	144	5	)	)	PUNCT
admet-761	144	6	0.01(±0.01	0.01(±0.01	ADJ
admet-761	144	7	)	)	PUNCT
admet-761	144	8	0.08(±0.03	0.08(±0.03	NUM
admet-761	144	9	)	)	PUNCT
admet-761	144	10	0.00	0.00	NUM
admet-761	144	11	0.04(±0.01	0.04(±0.01	NOUN
admet-761	144	12	)	)	PUNCT
admet-761	144	13	0.07(±0.02	0.07(±0.02	PROPN
admet-761	144	14	)	)	PUNCT
admet-761	144	15	ibuprofen	ibuprofen	NOUN
admet-761	144	16	-4.58	-4.58	NUM
admet-761	144	17	3.50	3.50	NUM
admet-761	144	18	4.43	4.43	NUM
admet-761	144	19	d	d	NOUN
admet-761	144	20	0.22(±0.03	0.22(±0.03	NOUN
admet-761	144	21	)	)	PUNCT
admet-761	144	22	0.00	0.00	NUM
admet-761	144	23	0.00	0.00	NUM
admet-761	144	24	0.19(±0.07	0.19(±0.07	NOUN
admet-761	144	25	)	)	PUNCT
admet-761	144	26	0.09(±0.03	0.09(±0.03	NOUN
admet-761	144	27	)	)	PUNCT
admet-761	144	28	0.00	0.00	NUM
admet-761	144	29	naproxen	naproxen	PROPN
admet-761	144	30	-4.97	-4.97	NOUN
admet-761	144	31	3.34	3.34	NUM
admet-761	144	32	4.28	4.28	NUM
admet-761	144	33	e	e	X
admet-761	144	34	0.13(±0.03	0.13(±0.03	NOUN
admet-761	144	35	)	)	PUNCT
admet-761	144	36	0.00	0.00	NUM
admet-761	144	37	0.00	0.00	NUM
admet-761	144	38	0.09(±0.02	0.09(±0.02	NOUN
admet-761	144	39	)	)	PUNCT
admet-761	144	40	0.04(±0.02	0.04(±0.02	NOUN
admet-761	144	41	)	)	PUNCT
admet-761	144	42	0.00	0.00	NUM
admet-761	144	43	progesterone	progesterone	NOUN
admet-761	144	44	-4.90	-4.90	NUM
admet-761	144	45	3.87	3.87	NUM
admet-761	144	46	0.50(±0.04	0.50(±0.04	NOUN
admet-761	144	47	)	)	PUNCT
admet-761	144	48	0.74(±0.01	0.74(±0.01	PROPN
admet-761	144	49	)	)	PUNCT
admet-761	144	50	0.88(±0.01	0.88(±0.01	PROPN
admet-761	144	51	)	)	PUNCT
admet-761	144	52	0.33(±0.01	0.33(±0.01	PROPN
admet-761	144	53	)	)	PUNCT
admet-761	144	54	0.62(±0.04	0.62(±0.04	NOUN
admet-761	144	55	)	)	PUNCT
admet-761	144	56	0.83(±0.02	0.83(±0.02	PROPN
admet-761	144	57	)	)	PUNCT
admet-761	144	58	a	a	PRON
admet-761	144	59	from	from	ADP
admet-761	144	60	reference	reference	NOUN
admet-761	144	61	[	[	X
admet-761	144	62	20	20	NUM
admet-761	144	63	]	]	PUNCT
admet-761	144	64	,	,	PUNCT
admet-761	144	65	b	b	X
admet-761	144	66	from	from	ADP
admet-761	144	67	reference	reference	NOUN
admet-761	144	68	[	[	X
admet-761	144	69	19	19	NUM
admet-761	144	70	]	]	PUNCT
admet-761	144	71	,	,	PUNCT
admet-761	144	72	c	c	NOUN
admet-761	144	73	from	from	ADP
admet-761	144	74	reference	reference	NOUN
admet-761	144	75	[	[	X
admet-761	144	76	21	21	NUM
admet-761	144	77	]	]	PUNCT
admet-761	144	78	,	,	PUNCT
admet-761	145	1	d	d	X
admet-761	145	2	from	from	ADP
admet-761	145	3	reference	reference	NOUN
admet-761	145	4	[	[	X
admet-761	145	5	22	22	NUM
admet-761	145	6	]	]	PUNCT
admet-761	145	7	,	,	PUNCT
admet-761	145	8	e	e	X
admet-761	145	9	from	from	ADP
admet-761	145	10	reference	reference	NOUN
admet-761	145	11	[	[	X
admet-761	145	12	23	23	NUM
admet-761	145	13	]	]	PUNCT
admet-761	145	14	the	the	DET
admet-761	145	15	membrane	membrane	NOUN
admet-761	145	16	retention	retention	NOUN
admet-761	145	17	values	value	NOUN
admet-761	145	18	at	at	ADP
admet-761	145	19	24	24	NUM
admet-761	145	20	h	h	NOUN
admet-761	145	21	incubation	incubation	NOUN
admet-761	145	22	time	time	NOUN
admet-761	145	23	have	have	AUX
admet-761	145	24	been	be	AUX
admet-761	145	25	correlated	correlate	VERB
admet-761	145	26	to	to	ADP
admet-761	145	27	the	the	DET
admet-761	145	28	log	log	NOUN
admet-761	145	29	po	po	PROPN
admet-761	145	30	/	/	SYM
admet-761	145	31	w	w	NOUN
admet-761	145	32	to	to	PART
admet-761	145	33	check	check	VERB
admet-761	145	34	if	if	SCONJ
admet-761	145	35	membrane	membrane	NOUN
admet-761	145	36	retention	retention	NOUN
admet-761	145	37	is	be	AUX
admet-761	145	38	related	relate	VERB
admet-761	145	39	to	to	ADP
admet-761	145	40	lipophilicity	lipophilicity	PROPN
admet-761	145	41	.	.	PUNCT
admet-761	146	1	flurbiprofen	flurbiprofen	NOUN
admet-761	146	2	,	,	PUNCT
admet-761	146	3	ibuprofen	ibuprofen	NOUN
admet-761	146	4	,	,	PUNCT
admet-761	146	5	and	and	CCONJ
admet-761	146	6	naproxen	naproxen	NOUN
admet-761	146	7	are	be	AUX
admet-761	146	8	excluded	exclude	VERB
admet-761	146	9	from	from	ADP
admet-761	146	10	the	the	DET
admet-761	146	11	correlation	correlation	NOUN
admet-761	146	12	due	due	ADP
admet-761	146	13	to	to	ADP
admet-761	146	14	the	the	DET
admet-761	146	15	reasons	reason	NOUN
admet-761	146	16	above	above	ADP
admet-761	146	17	mentioned	mention	VERB
admet-761	146	18	.	.	PUNCT
admet-761	147	1	a	a	DET
admet-761	147	2	sigmoidal	sigmoidal	NOUN
admet-761	147	3	relationship	relationship	NOUN
admet-761	147	4	between	between	ADP
admet-761	147	5	rm	rm	PROPN
admet-761	147	6	and	and	CCONJ
admet-761	147	7	log	log	VERB
admet-761	147	8	po	po	PROPN
admet-761	147	9	/	/	SYM
admet-761	147	10	w	w	PROPN
admet-761	147	11	,	,	PUNCT
admet-761	147	12	which	which	PRON
admet-761	147	13	can	can	AUX
admet-761	147	14	be	be	AUX
admet-761	147	15	explained	explain	VERB
admet-761	147	16	by	by	ADP
admet-761	147	17	equation	equation	NOUN
admet-761	147	18	6	6	NUM
admet-761	147	19	(	(	PUNCT
admet-761	147	20	see	see	VERB
admet-761	147	21	appendix	appendix	NOUN
admet-761	147	22	)	)	PUNCT
admet-761	147	23	,	,	PUNCT
admet-761	147	24	can	can	AUX
admet-761	147	25	be	be	AUX
admet-761	147	26	observed	observe	VERB
admet-761	147	27	for	for	ADP
admet-761	147	28	the	the	DET
admet-761	147	29	rest	rest	NOUN
admet-761	147	30	of	of	ADP
admet-761	147	31	the	the	DET
admet-761	147	32	drugs	drug	NOUN
admet-761	147	33	,	,	PUNCT
admet-761	147	34	which	which	PRON
admet-761	147	35	are	be	AUX
admet-761	147	36	mainly	mainly	ADV
admet-761	147	37	in	in	ADP
admet-761	147	38	its	its	PRON
admet-761	147	39	neutral	neutral	ADJ
admet-761	147	40	form	form	NOUN
admet-761	147	41	.	.	PUNCT
admet-761	148	1	(	(	PUNCT
admet-761	148	2	6	6	X
admet-761	148	3	)	)	PUNCT
admet-761	148	4	figure	figure	NOUN
admet-761	148	5	2	2	NUM
admet-761	148	6	.	.	X
admet-761	148	7	relationship	relationship	NOUN
admet-761	148	8	between	between	ADP
admet-761	148	9	membrane	membrane	NOUN
admet-761	148	10	retention	retention	NOUN
admet-761	148	11	(	(	PUNCT
admet-761	148	12	rm	rm	NOUN
admet-761	148	13	)	)	PUNCT
admet-761	148	14	and	and	CCONJ
admet-761	148	15	lipophilicity	lipophilicity	NOUN
admet-761	148	16	(	(	PUNCT
admet-761	148	17	log	log	VERB
admet-761	148	18	po	po	PROPN
admet-761	148	19	/	/	SYM
admet-761	148	20	w	w	PROPN
admet-761	148	21	)	)	PUNCT
admet-761	148	22	at	at	ADP
admet-761	148	23	24	24	NUM
admet-761	148	24	h	h	NOUN
admet-761	148	25	incubation	incubation	NOUN
admet-761	148	26	time	time	NOUN
admet-761	148	27	without	without	ADP
admet-761	148	28	stirring	stir	VERB
admet-761	148	29	.	.	PUNCT
admet-761	149	1	in	in	ADP
admet-761	149	2	this	this	DET
admet-761	149	3	equation	equation	NOUN
admet-761	149	4	d	d	NOUN
admet-761	149	5	is	be	AUX
admet-761	149	6	the	the	DET
admet-761	149	7	distribution	distribution	NOUN
admet-761	149	8	coefficient	coefficient	NOUN
admet-761	149	9	between	between	ADP
admet-761	149	10	water	water	NOUN
admet-761	149	11	and	and	CCONJ
admet-761	149	12	membrane	membrane	NOUN
admet-761	149	13	(	(	PUNCT
admet-761	149	14	ph	ph	NOUN
admet-761	149	15	dependent	dependent	ADJ
admet-761	149	16	)	)	PUNCT
admet-761	149	17	,	,	PUNCT
admet-761	149	18	vwater	vwater	NOUN
admet-761	149	19	is	be	AUX
admet-761	149	20	the	the	DET
admet-761	149	21	volume	volume	NOUN
admet-761	149	22	of	of	ADP
admet-761	149	23	the	the	DET
admet-761	149	24	aqueous	aqueous	ADJ
admet-761	149	25	compartment	compartment	NOUN
admet-761	149	26	,	,	PUNCT
admet-761	149	27	and	and	CCONJ
admet-761	149	28	vmembrane	vmembrane	PROPN
admet-761	149	29	is	be	AUX
admet-761	149	30	the	the	DET
admet-761	149	31	volume	volume	NOUN
admet-761	149	32	of	of	ADP
admet-761	149	33	the	the	DET
admet-761	149	34	membrane	membrane	NOUN
admet-761	149	35	.	.	PUNCT
admet-761	150	1	figure	figure	NOUN
admet-761	150	2	2	2	NUM
admet-761	150	3	shows	show	VERB
admet-761	150	4	the	the	DET
admet-761	150	5	fit	fit	NOUN
admet-761	150	6	of	of	ADP
admet-761	150	7	equation	equation	NOUN
admet-761	150	8	6	6	NUM
admet-761	150	9	(	(	PUNCT
admet-761	150	10	using	use	VERB
admet-761	150	11	po	po	NOUN
admet-761	150	12	/	/	SYM
admet-761	150	13	w	w	PROPN
admet-761	150	14	of	of	ADP
admet-761	150	15	the	the	DET
admet-761	150	16	compounds	compound	NOUN
admet-761	150	17	instead	instead	ADV
admet-761	150	18	of	of	ADP
admet-761	150	19	log	log	NOUN
admet-761	150	20	d	d	NOUN
admet-761	150	21	)	)	PUNCT
admet-761	150	22	to	to	ADP
admet-761	150	23	the	the	DET
admet-761	150	24	experimental	experimental	ADJ
admet-761	150	25	data	datum	NOUN
admet-761	150	26	(	(	PUNCT
admet-761	150	27	24	24	NUM
admet-761	150	28	h	h	NOUN
admet-761	150	29	incubation	incubation	NOUN
admet-761	150	30	time	time	NOUN
admet-761	150	31	without	without	ADP
admet-761	150	32	stirring	stirring	NOUN
admet-761	150	33	)	)	PUNCT
admet-761	150	34	.	.	PUNCT
admet-761	151	1	good	good	ADJ
admet-761	151	2	statistics	statistic	NOUN
admet-761	151	3	are	be	AUX
admet-761	151	4	obtained	obtain	VERB
admet-761	151	5	(	(	PUNCT
admet-761	151	6	r2	r2	PROPN
admet-761	151	7	=	=	PUNCT
admet-761	151	8	0.951	0.951	NUM
admet-761	151	9	,	,	PUNCT
admet-761	151	10	sd	sd	ADP
admet-761	151	11	=	=	SYM
admet-761	151	12	0.066	0.066	NUM
admet-761	151	13	,	,	PUNCT
admet-761	151	14	f	f	PROPN
admet-761	151	15	=	=	SYM
admet-761	151	16	98	98	NUM
admet-761	151	17	)	)	PUNCT
admet-761	151	18	,	,	PUNCT
admet-761	151	19	with	with	ADP
admet-761	151	20	a	a	DET
admet-761	151	21	value	value	NOUN
admet-761	151	22	of	of	ADP
admet-761	151	23	3.19	3.19	NUM
admet-761	151	24	±	±	NUM
admet-761	151	25	0.11	0.11	NUM
admet-761	151	26	for	for	ADP
admet-761	151	27	the	the	DET
admet-761	151	28	parameter	parameter	NOUN
admet-761	151	29	log	log	NOUN
admet-761	151	30	(	(	PUNCT
admet-761	151	31	vwater	vwater	NOUN
admet-761	151	32	/	/	SYM
admet-761	151	33	vmembrane	vmembrane	PROPN
admet-761	151	34	)	)	PUNCT
admet-761	151	35	.	.	PUNCT
admet-761	152	1	this	this	PRON
admet-761	152	2	is	be	AUX
admet-761	152	3	a	a	DET
admet-761	152	4	good	good	ADJ
admet-761	152	5	fit	fit	NOUN
admet-761	152	6	given	give	VERB
admet-761	152	7	that	that	SCONJ
admet-761	152	8	the	the	DET
admet-761	152	9	true	true	ADJ
admet-761	152	10	equilibrium	equilibrium	NOUN
admet-761	152	11	may	may	AUX
admet-761	152	12	not	not	PART
admet-761	152	13	have	have	AUX
admet-761	152	14	been	be	AUX
admet-761	152	15	achieved	achieve	VERB
admet-761	152	16	,	,	PUNCT
admet-761	152	17	ionisation	ionisation	NOUN
admet-761	152	18	of	of	ADP
admet-761	152	19	some	some	DET
admet-761	152	20	compounds	compound	NOUN
admet-761	152	21	has	have	AUX
admet-761	152	22	been	be	AUX
admet-761	152	23	neglected	neglect	VERB
admet-761	152	24	,	,	PUNCT
admet-761	152	25	and	and	CCONJ
admet-761	152	26	octanol	octanol	NOUN
admet-761	152	27	is	be	AUX
admet-761	152	28	expected	expect	VERB
admet-761	152	29	to	to	PART
admet-761	152	30	be	be	AUX
admet-761	152	31	more	more	ADV
admet-761	152	32	lipophilic	lipophilic	ADJ
admet-761	152	33	than	than	ADP
admet-761	152	34	the	the	DET
admet-761	152	35	membrane	membrane	NOUN
admet-761	152	36	.	.	PUNCT
admet-761	153	1	from	from	ADP
admet-761	153	2	correlations	correlation	NOUN
admet-761	153	3	established	establish	VERB
admet-761	153	4	in	in	ADP
admet-761	153	5	figure	figure	NOUN
admet-761	153	6	1	1	NUM
admet-761	153	7	a	a	NOUN
admet-761	153	8	-	-	PUNCT
admet-761	153	9	c	c	NOUN
admet-761	153	10	,	,	PUNCT
admet-761	153	11	it	it	PRON
admet-761	153	12	can	can	AUX
admet-761	153	13	be	be	AUX
admet-761	153	14	observed	observe	VERB
admet-761	153	15	that	that	SCONJ
admet-761	153	16	the	the	DET
admet-761	153	17	slopes	slope	NOUN
admet-761	153	18	are	be	AUX
admet-761	153	19	very	very	ADV
admet-761	153	20	close	close	ADJ
admet-761	153	21	and	and	CCONJ
admet-761	153	22	very	very	ADV
admet-761	153	23	low	low	ADJ
admet-761	153	24	data	datum	NOUN
admet-761	153	25	dispersion	dispersion	NOUN
admet-761	153	26	is	be	AUX
admet-761	153	27	observed	observe	VERB
admet-761	153	28	.	.	PUNCT
admet-761	154	1	hence	hence	ADV
admet-761	154	2	,	,	PUNCT
admet-761	154	3	the	the	DET
admet-761	154	4	assay	assay	NOUN
admet-761	154	5	conditions	condition	NOUN
admet-761	154	6	using	use	VERB
admet-761	154	7	an	an	DET
admet-761	154	8	incubation	incubation	NOUN
admet-761	154	9	time	time	NOUN
admet-761	154	10	of	of	ADP
admet-761	154	11	4	4	NUM
admet-761	154	12	hours	hour	NOUN
admet-761	154	13	(	(	PUNCT
admet-761	154	14	figure	figure	NOUN
admet-761	154	15	1b	1b	NUM
admet-761	154	16	)	)	PUNCT
admet-761	154	17	and	and	CCONJ
admet-761	154	18	taking	take	VERB
admet-761	154	19	advantage	advantage	NOUN
admet-761	154	20	of	of	ADP
admet-761	154	21	stirring	stir	VERB
admet-761	154	22	to	to	PART
admet-761	154	23	decrease	decrease	VERB
admet-761	154	24	as	as	ADV
admet-761	154	25	much	much	ADV
admet-761	154	26	as	as	ADP
admet-761	154	27	possible	possible	ADJ
admet-761	154	28	the	the	DET
admet-761	154	29	thickness	thickness	NOUN
admet-761	154	30	of	of	ADP
admet-761	154	31	the	the	DET
admet-761	154	32	aqueous	aqueous	ADJ
admet-761	154	33	boundary	boundary	ADJ
admet-761	154	34	layer	layer	NOUN
admet-761	154	35	are	be	AUX
admet-761	154	36	considered	consider	VERB
admet-761	154	37	the	the	DET
admet-761	154	38	most	most	ADV
admet-761	154	39	appropriate	appropriate	ADJ
admet-761	154	40	.	.	PUNCT
admet-761	155	1	working	work	VERB
admet-761	155	2	under	under	ADP
admet-761	155	3	these	these	DET
admet-761	155	4	conditions	condition	NOUN
admet-761	155	5	permits	permit	NOUN
admet-761	155	6	to	to	PART
admet-761	155	7	evaluate	evaluate	VERB
admet-761	155	8	the	the	DET
admet-761	155	9	greatest	great	ADJ
admet-761	155	10	number	number	NOUN
admet-761	155	11	of	of	ADP
admet-761	155	12	compounds	compound	NOUN
admet-761	155	13	,	,	PUNCT
admet-761	155	14	despite	despite	SCONJ
admet-761	155	15	in	in	ADP
admet-761	155	16	some	some	DET
admet-761	155	17	cases	case	NOUN
admet-761	155	18	,	,	PUNCT
admet-761	155	19	such	such	ADJ
admet-761	155	20	as	as	ADP
admet-761	155	21	digitoxin	digitoxin	PROPN
admet-761	155	22	,	,	PUNCT
admet-761	155	23	longer	long	ADJ
admet-761	155	24	incubation	incubation	NOUN
admet-761	155	25	might	might	AUX
admet-761	155	26	be	be	AUX
admet-761	155	27	needed	need	VERB
admet-761	155	28	.	.	PUNCT
admet-761	156	1	study	study	NOUN
admet-761	156	2	of	of	ADP
admet-761	156	3	membrane	membrane	NOUN
admet-761	156	4	stability	stability	NOUN
admet-761	156	5	the	the	DET
admet-761	156	6	stability	stability	NOUN
admet-761	156	7	of	of	ADP
admet-761	156	8	the	the	DET
admet-761	156	9	skin	skin	NOUN
admet-761	156	10	-	-	PUNCT
admet-761	156	11	pampa	pampa	NOUN
admet-761	156	12	membrane	membrane	NOUN
admet-761	156	13	at	at	ADP
admet-761	156	14	basic	basic	ADJ
admet-761	156	15	ph	ph	ADJ
admet-761	156	16	values	value	NOUN
admet-761	156	17	was	be	AUX
admet-761	156	18	studied	study	VERB
admet-761	156	19	through	through	ADP
admet-761	156	20	measurement	measurement	NOUN
admet-761	156	21	of	of	ADP
admet-761	156	22	the	the	DET
admet-761	156	23	permeability	permeability	NOUN
admet-761	156	24	of	of	ADP
admet-761	156	25	11	11	NUM
admet-761	156	26	compounds	compound	NOUN
admet-761	156	27	(	(	PUNCT
admet-761	156	28	3	3	NUM
admet-761	156	29	acids	acid	NOUN
admet-761	156	30	,	,	PUNCT
admet-761	156	31	5	5	NUM
admet-761	156	32	bases	basis	NOUN
admet-761	156	33	and	and	CCONJ
admet-761	156	34	3	3	NUM
admet-761	156	35	neutrals	neutral	NOUN
admet-761	156	36	)	)	PUNCT
admet-761	156	37	.	.	PUNCT
admet-761	157	1	the	the	DET
admet-761	157	2	skin	skin	NOUN
admet-761	157	3	-	-	PUNCT
admet-761	157	4	pampa	pampa	NOUN
admet-761	157	5	membrane	membrane	NOUN
admet-761	157	6	was	be	AUX
admet-761	157	7	hydrated	hydrated	ADJ
admet-761	157	8	with	with	ADP
admet-761	157	9	diluted	dilute	VERB
admet-761	157	10	prisma	prisma	NOUN
admet-761	157	11	httm	httm	NOUN
admet-761	157	12	buffer	buffer	VERB
admet-761	157	13	solution	solution	NOUN
admet-761	157	14	at	at	ADP
admet-761	157	15	ph	ph	PROPN
admet-761	157	16	7	7	NUM
admet-761	157	17	,	,	PUNCT
admet-761	157	18	8	8	NUM
admet-761	157	19	,	,	PUNCT
admet-761	157	20	9	9	NUM
admet-761	157	21	and	and	CCONJ
admet-761	157	22	10	10	NUM
admet-761	157	23	during	during	ADP
admet-761	157	24	30	30	NUM
admet-761	157	25	min	min	NOUN
admet-761	157	26	and	and	CCONJ
admet-761	157	27	4	4	NUM
admet-761	157	28	hours	hour	NOUN
admet-761	157	29	,	,	PUNCT
admet-761	157	30	to	to	PART
admet-761	157	31	be	be	AUX
admet-761	157	32	consistent	consistent	ADJ
admet-761	157	33	with	with	ADP
admet-761	157	34	incubation	incubation	NOUN
admet-761	157	35	times	time	NOUN
admet-761	157	36	selected	select	VERB
admet-761	157	37	in	in	ADP
admet-761	157	38	section	section	NOUN
admet-761	157	39	3.1	3.1	NUM
admet-761	157	40	.	.	PUNCT
admet-761	158	1	then	then	ADV
admet-761	158	2	,	,	PUNCT
admet-761	158	3	a	a	DET
admet-761	158	4	standard	standard	ADJ
admet-761	158	5	permeation	permeation	NOUN
admet-761	158	6	assay	assay	NOUN
admet-761	158	7	was	be	AUX
admet-761	158	8	carried	carry	VERB
admet-761	158	9	out	out	ADP
admet-761	158	10	with	with	ADP
admet-761	158	11	an	an	DET
admet-761	158	12	incubation	incubation	NOUN
admet-761	158	13	time	time	NOUN
admet-761	158	14	of	of	ADP
admet-761	158	15	4	4	NUM
admet-761	158	16	h	h	NOUN
admet-761	158	17	and	and	CCONJ
admet-761	158	18	stirring	stir	VERB
admet-761	158	19	at	at	ADP
admet-761	158	20	ph	ph	NOUN
admet-761	158	21	5	5	NUM
admet-761	158	22	in	in	ADP
admet-761	158	23	the	the	DET
admet-761	158	24	donor	donor	NOUN
admet-761	158	25	compartment	compartment	NOUN
admet-761	158	26	and	and	CCONJ
admet-761	158	27	ph	ph	VERB
admet-761	158	28	7.4	7.4	NUM
admet-761	158	29	in	in	ADP
admet-761	158	30	the	the	DET
admet-761	158	31	acceptor	acceptor	NOUN
admet-761	158	32	compartment	compartment	NOUN
admet-761	158	33	.	.	PUNCT
admet-761	159	1	simultaneously	simultaneously	ADV
admet-761	159	2	,	,	PUNCT
admet-761	159	3	permeation	permeation	NOUN
admet-761	159	4	assays	assay	NOUN
admet-761	159	5	were	be	AUX
admet-761	159	6	also	also	ADV
admet-761	159	7	performed	perform	VERB
admet-761	159	8	without	without	ADP
admet-761	159	9	the	the	DET
admet-761	159	10	previous	previous	ADJ
admet-761	159	11	soaking	soaking	NOUN
admet-761	159	12	treatment	treatment	NOUN
admet-761	159	13	at	at	ADP
admet-761	159	14	basic	basic	ADJ
admet-761	159	15	ph	ph	NOUN
admet-761	159	16	.	.	PUNCT
admet-761	160	1	the	the	DET
admet-761	160	2	obtained	obtain	VERB
admet-761	160	3	results	result	NOUN
admet-761	160	4	are	be	AUX
admet-761	160	5	presented	present	VERB
admet-761	160	6	in	in	ADP
admet-761	160	7	figure	figure	NOUN
admet-761	160	8	3	3	NUM
admet-761	160	9	,	,	PUNCT
admet-761	160	10	which	which	PRON
admet-761	160	11	shows	show	VERB
admet-761	160	12	the	the	DET
admet-761	160	13	skin	skin	NOUN
admet-761	160	14	-	-	PUNCT
admet-761	160	15	pampa	pampa	NOUN
admet-761	160	16	log	log	NOUN
admet-761	160	17	pe	pe	PROPN
admet-761	160	18	values	value	NOUN
admet-761	160	19	obtained	obtain	VERB
admet-761	160	20	with	with	ADP
admet-761	160	21	and	and	CCONJ
admet-761	160	22	without	without	ADP
admet-761	160	23	the	the	DET
admet-761	160	24	previous	previous	ADJ
admet-761	160	25	treatment	treatment	NOUN
admet-761	160	26	.	.	PUNCT
admet-761	161	1	each	each	DET
admet-761	161	2	subfigure	subfigure	NOUN
admet-761	161	3	corresponds	correspond	VERB
admet-761	161	4	to	to	ADP
admet-761	161	5	a	a	DET
admet-761	161	6	compound	compound	NOUN
admet-761	161	7	and	and	CCONJ
admet-761	161	8	the	the	DET
admet-761	161	9	straight	straight	ADJ
admet-761	161	10	line	line	NOUN
admet-761	161	11	inside	inside	ADP
admet-761	161	12	the	the	DET
admet-761	161	13	figure	figure	NOUN
admet-761	161	14	is	be	AUX
admet-761	161	15	the	the	DET
admet-761	161	16	log	log	NOUN
admet-761	161	17	pe	pe	NOUN
admet-761	161	18	value	value	NOUN
admet-761	161	19	in	in	ADP
admet-761	161	20	the	the	DET
admet-761	161	21	untreated	untreated	ADJ
admet-761	161	22	membrane	membrane	NOUN
admet-761	161	23	.	.	PUNCT
admet-761	162	1	an	an	DET
admet-761	162	2	increase	increase	NOUN
admet-761	162	3	of	of	ADP
admet-761	162	4	permeability	permeability	NOUN
admet-761	162	5	values	value	NOUN
admet-761	162	6	at	at	ADP
admet-761	162	7	ph	ph	PROPN
admet-761	162	8	9	9	NUM
admet-761	162	9	and	and	CCONJ
admet-761	162	10	10	10	NUM
admet-761	162	11	is	be	AUX
admet-761	162	12	shown	show	VERB
admet-761	162	13	in	in	ADP
admet-761	162	14	figure	figure	NOUN
admet-761	162	15	3	3	NUM
admet-761	162	16	for	for	ADP
admet-761	162	17	almost	almost	ADV
admet-761	162	18	all	all	DET
admet-761	162	19	the	the	DET
admet-761	162	20	compounds	compound	NOUN
admet-761	162	21	,	,	PUNCT
admet-761	162	22	which	which	PRON
admet-761	162	23	points	point	VERB
admet-761	162	24	out	out	ADP
admet-761	162	25	the	the	DET
admet-761	162	26	lack	lack	NOUN
admet-761	162	27	of	of	ADP
admet-761	162	28	stability	stability	NOUN
admet-761	162	29	of	of	ADP
admet-761	162	30	the	the	DET
admet-761	162	31	membrane	membrane	NOUN
admet-761	162	32	in	in	ADP
admet-761	162	33	this	this	DET
admet-761	162	34	ph	ph	ADJ
admet-761	162	35	range	range	NOUN
admet-761	162	36	.	.	PUNCT
admet-761	163	1	in	in	ADP
admet-761	163	2	some	some	DET
admet-761	163	3	cases	case	NOUN
admet-761	163	4	,	,	PUNCT
admet-761	163	5	such	such	ADJ
admet-761	163	6	as	as	ADP
admet-761	163	7	aminopyrine	aminopyrine	NOUN
admet-761	163	8	,	,	PUNCT
admet-761	163	9	some	some	DET
admet-761	163	10	distortion	distortion	NOUN
admet-761	163	11	is	be	AUX
admet-761	163	12	already	already	ADV
admet-761	163	13	noted	note	VERB
admet-761	163	14	at	at	ADP
admet-761	163	15	ph	ph	PROPN
admet-761	163	16	8	8	NUM
admet-761	163	17	.	.	PUNCT
admet-761	164	1	as	as	SCONJ
admet-761	164	2	described	describe	VERB
admet-761	164	3	in	in	ADP
admet-761	164	4	the	the	DET
admet-761	164	5	literature	literature	NOUN
admet-761	164	6	[	[	X
admet-761	164	7	16	16	NUM
admet-761	164	8	]	]	PUNCT
admet-761	164	9	,	,	PUNCT
admet-761	164	10	solutions	solution	NOUN
admet-761	164	11	at	at	ADP
admet-761	164	12	ph	ph	PROPN
admet-761	164	13	7	7	NUM
admet-761	164	14	or	or	CCONJ
admet-761	164	15	higher	high	ADJ
admet-761	164	16	produce	produce	VERB
admet-761	164	17	a	a	DET
admet-761	164	18	change	change	NOUN
admet-761	164	19	of	of	ADP
admet-761	164	20	membrane	membrane	NOUN
admet-761	164	21	packaging	packaging	NOUN
admet-761	164	22	in	in	ADP
admet-761	164	23	human	human	ADJ
admet-761	164	24	skin	skin	NOUN
admet-761	164	25	.	.	PUNCT
admet-761	165	1	however	however	ADV
admet-761	165	2	,	,	PUNCT
admet-761	165	3	in	in	ADP
admet-761	165	4	the	the	DET
admet-761	165	5	skin	skin	NOUN
admet-761	165	6	-	-	PUNCT
admet-761	165	7	pampa	pampa	NOUN
admet-761	165	8	membrane	membrane	NOUN
admet-761	165	9	loose	loose	ADJ
admet-761	165	10	of	of	ADP
admet-761	165	11	stability	stability	NOUN
admet-761	165	12	is	be	AUX
admet-761	165	13	not	not	PART
admet-761	165	14	observed	observe	VERB
admet-761	165	15	up	up	ADP
admet-761	165	16	to	to	ADP
admet-761	165	17	ph	ph	ADJ
admet-761	165	18	8	8	NUM
admet-761	165	19	,	,	PUNCT
admet-761	165	20	probably	probably	ADV
admet-761	165	21	due	due	ADP
admet-761	165	22	to	to	ADP
admet-761	165	23	the	the	DET
admet-761	165	24	different	different	ADJ
admet-761	165	25	membrane	membrane	NOUN
admet-761	165	26	composition	composition	NOUN
admet-761	165	27	.	.	PUNCT
admet-761	166	1	in	in	ADP
admet-761	166	2	most	most	ADJ
admet-761	166	3	cases	case	NOUN
admet-761	166	4	,	,	PUNCT
admet-761	166	5	the	the	DET
admet-761	166	6	permeability	permeability	NOUN
admet-761	166	7	values	value	NOUN
admet-761	166	8	increase	increase	VERB
admet-761	166	9	for	for	ADP
admet-761	166	10	both	both	DET
admet-761	166	11	30	30	NUM
admet-761	166	12	minutes	minute	NOUN
admet-761	166	13	and	and	CCONJ
admet-761	166	14	4	4	NUM
admet-761	166	15	hours	hour	NOUN
admet-761	166	16	of	of	ADP
admet-761	166	17	treatment	treatment	NOUN
admet-761	166	18	,	,	PUNCT
admet-761	166	19	meaning	mean	VERB
admet-761	166	20	that	that	SCONJ
admet-761	166	21	at	at	ADP
admet-761	166	22	30	30	NUM
admet-761	166	23	minutes	minute	NOUN
admet-761	166	24	the	the	DET
admet-761	166	25	stability	stability	NOUN
admet-761	166	26	of	of	ADP
admet-761	166	27	the	the	DET
admet-761	166	28	membrane	membrane	NOUN
admet-761	166	29	is	be	AUX
admet-761	166	30	already	already	ADV
admet-761	166	31	altered	alter	VERB
admet-761	166	32	by	by	ADP
admet-761	166	33	the	the	DET
admet-761	166	34	basic	basic	ADJ
admet-761	166	35	ph	ph	PROPN
admet-761	166	36	.	.	PROPN
admet-761	166	37	griseofulvin	griseofulvin	NOUN
admet-761	166	38	and	and	CCONJ
admet-761	166	39	warfarin	warfarin	NOUN
admet-761	166	40	have	have	VERB
admet-761	166	41	a	a	DET
admet-761	166	42	slight	slight	ADJ
admet-761	166	43	increase	increase	NOUN
admet-761	166	44	at	at	ADP
admet-761	166	45	ph	ph	PROPN
admet-761	166	46	9	9	NUM
admet-761	166	47	and	and	CCONJ
admet-761	166	48	10	10	NUM
admet-761	166	49	.	.	PUNCT
admet-761	167	1	the	the	DET
admet-761	167	2	values	value	NOUN
admet-761	167	3	of	of	ADP
admet-761	167	4	indomethacin	indomethacin	NOUN
admet-761	167	5	,	,	PUNCT
admet-761	167	6	2	2	NUM
admet-761	167	7	-	-	PUNCT
admet-761	167	8	toluidine	toluidine	NOUN
admet-761	167	9	and	and	CCONJ
admet-761	167	10	sufentanyl	sufentanyl	NOUN
admet-761	167	11	,	,	PUNCT
admet-761	167	12	however	however	ADV
admet-761	167	13	,	,	PUNCT
admet-761	167	14	remain	remain	VERB
admet-761	167	15	constant	constant	ADJ
admet-761	167	16	.	.	PUNCT
admet-761	168	1	as	as	ADP
admet-761	168	2	a	a	DET
admet-761	168	3	general	general	ADJ
admet-761	168	4	trend	trend	NOUN
admet-761	168	5	,	,	PUNCT
admet-761	168	6	it	it	PRON
admet-761	168	7	seems	seem	VERB
admet-761	168	8	that	that	SCONJ
admet-761	168	9	this	this	DET
admet-761	168	10	problem	problem	NOUN
admet-761	168	11	is	be	AUX
admet-761	168	12	more	more	ADV
admet-761	168	13	important	important	ADJ
admet-761	168	14	when	when	SCONJ
admet-761	168	15	the	the	DET
admet-761	168	16	compound	compound	NOUN
admet-761	168	17	is	be	AUX
admet-761	168	18	less	less	ADV
admet-761	168	19	permeable	permeable	ADJ
admet-761	168	20	(	(	PUNCT
admet-761	168	21	log	log	NOUN
admet-761	168	22	 	 	SPACE
admet-761	168	23	pe	pe	PROPN
admet-761	168	24	below	below	ADP
admet-761	168	25	-5	-5	ADP
admet-761	168	26	)	)	PUNCT
admet-761	168	27	regardless	regardless	ADV
admet-761	168	28	of	of	ADP
admet-761	168	29	the	the	DET
admet-761	168	30	nature	nature	NOUN
admet-761	168	31	and	and	CCONJ
admet-761	168	32	ionization	ionization	NOUN
admet-761	168	33	of	of	ADP
admet-761	168	34	the	the	DET
admet-761	168	35	compound	compound	NOUN
admet-761	168	36	.	.	PUNCT
admet-761	169	1	in	in	ADP
admet-761	169	2	conclusion	conclusion	NOUN
admet-761	169	3	,	,	PUNCT
admet-761	169	4	although	although	SCONJ
admet-761	169	5	the	the	DET
admet-761	169	6	prisma	prisma	NOUN
admet-761	169	7	httm	httm	NOUN
admet-761	169	8	universal	universal	ADJ
admet-761	169	9	buffer	buffer	NOUN
admet-761	169	10	solution	solution	NOUN
admet-761	169	11	suggests	suggest	VERB
admet-761	169	12	a	a	DET
admet-761	169	13	working	work	VERB
admet-761	169	14	ph	ph	ADJ
admet-761	169	15	range	range	NOUN
admet-761	169	16	between	between	ADP
admet-761	169	17	3	3	NUM
admet-761	169	18	and	and	CCONJ
admet-761	169	19	10	10	NUM
admet-761	169	20	,	,	PUNCT
admet-761	169	21	it	it	PRON
admet-761	169	22	is	be	AUX
admet-761	169	23	advisable	advisable	ADJ
admet-761	169	24	not	not	PART
admet-761	169	25	to	to	PART
admet-761	169	26	exceed	exceed	VERB
admet-761	169	27	ph	ph	NOUN
admet-761	169	28	8	8	NUM
admet-761	169	29	to	to	PART
admet-761	169	30	avoid	avoid	VERB
admet-761	169	31	damaging	damage	VERB
admet-761	169	32	the	the	DET
admet-761	169	33	skin	skin	NOUN
admet-761	169	34	-	-	PUNCT
admet-761	169	35	pampa	pampa	NOUN
admet-761	169	36	membrane	membrane	NOUN
admet-761	169	37	.	.	PUNCT
admet-761	170	1	in	in	ADP
admet-761	170	2	that	that	DET
admet-761	170	3	cases	case	NOUN
admet-761	170	4	where	where	SCONJ
admet-761	170	5	permeability	permeability	NOUN
admet-761	170	6	must	must	AUX
admet-761	170	7	be	be	AUX
admet-761	170	8	determined	determine	VERB
admet-761	170	9	at	at	ADP
admet-761	170	10	ph	ph	ADJ
admet-761	170	11	values	value	NOUN
admet-761	170	12	higher	high	ADJ
admet-761	170	13	than	than	ADP
admet-761	170	14	eight	eight	NUM
admet-761	170	15	(	(	PUNCT
admet-761	170	16	for	for	ADP
admet-761	170	17	example	example	NOUN
admet-761	170	18	to	to	PART
admet-761	170	19	determine	determine	VERB
admet-761	170	20	the	the	DET
admet-761	170	21	log	log	NOUN
admet-761	170	22	pe	pe	INTJ
admet-761	170	23	of	of	ADP
admet-761	170	24	the	the	DET
admet-761	170	25	neutral	neutral	ADJ
admet-761	170	26	forms	form	NOUN
admet-761	170	27	of	of	ADP
admet-761	170	28	bases	basis	NOUN
admet-761	170	29	with	with	ADP
admet-761	170	30	pka	pka	PROPN
admet-761	170	31	values	value	NOUN
admet-761	170	32	higher	high	ADJ
admet-761	170	33	than	than	ADP
admet-761	170	34	7	7	NUM
admet-761	170	35	)	)	PUNCT
admet-761	170	36	alternative	alternative	ADJ
admet-761	170	37	methods	method	NOUN
admet-761	170	38	should	should	AUX
admet-761	170	39	be	be	AUX
admet-761	170	40	used	use	VERB
admet-761	170	41	,	,	PUNCT
admet-761	170	42	such	such	DET
admet-761	170	43	the	the	DET
admet-761	170	44	estimation	estimation	NOUN
admet-761	170	45	equations	equation	NOUN
admet-761	170	46	proposed	propose	VERB
admet-761	170	47	by	by	ADP
admet-761	170	48	zhang	zhang	PROPN
admet-761	170	49	et	et	PROPN
admet-761	170	50	al	al	PROPN
admet-761	170	51	.	.	PUNCT
admet-761	171	1	[	[	X
admet-761	171	2	18	18	NUM
admet-761	171	3	]	]	PUNCT
admet-761	171	4	or	or	CCONJ
admet-761	171	5	estimation	estimation	NOUN
admet-761	171	6	through	through	ADP
admet-761	171	7	chromatographic	chromatographic	ADJ
admet-761	171	8	measurements	measurement	NOUN
admet-761	171	9	[	[	X
admet-761	171	10	24	24	NUM
admet-761	171	11	]	]	PUNCT
admet-761	171	12	.	.	PUNCT
admet-761	172	1	correlation	correlation	NOUN
admet-761	172	2	with	with	ADP
admet-761	172	3	human	human	ADJ
admet-761	172	4	skin	skin	NOUN
admet-761	172	5	permeation	permeation	NOUN
admet-761	172	6	data	data	VERB
admet-761	172	7	the	the	DET
admet-761	172	8	skin	skin	NOUN
admet-761	172	9	-	-	PUNCT
admet-761	172	10	pampa	pampa	NOUN
admet-761	172	11	permeability	permeability	NOUN
admet-761	172	12	(	(	PUNCT
admet-761	172	13	pe	pe	INTJ
admet-761	172	14	)	)	PUNCT
admet-761	172	15	of	of	ADP
admet-761	172	16	a	a	DET
admet-761	172	17	large	large	ADJ
admet-761	172	18	acid	acid	NOUN
admet-761	172	19	-	-	PUNCT
admet-761	172	20	base	base	NOUN
admet-761	172	21	drugs	drug	NOUN
admet-761	172	22	dataset	dataset	NOUN
admet-761	172	23	(	(	PUNCT
admet-761	172	24	n=46	n=46	NOUN
admet-761	172	25	)	)	PUNCT
admet-761	172	26	obtained	obtain	VERB
admet-761	172	27	in	in	ADP
admet-761	172	28	the	the	DET
admet-761	172	29	optimized	optimize	VERB
admet-761	172	30	assay	assay	NOUN
admet-761	172	31	conditions	condition	NOUN
admet-761	172	32	previously	previously	ADV
admet-761	172	33	discussed	discuss	VERB
admet-761	172	34	has	have	AUX
admet-761	172	35	been	be	AUX
admet-761	172	36	correlated	correlate	VERB
admet-761	172	37	with	with	ADP
admet-761	172	38	literature	literature	NOUN
admet-761	172	39	skin	skin	NOUN
admet-761	172	40	permeability	permeability	NOUN
admet-761	172	41	(	(	PUNCT
admet-761	172	42	kp	kp	PROPN
admet-761	172	43	)	)	PUNCT
admet-761	172	44	.	.	PUNCT
admet-761	173	1	the	the	DET
admet-761	173	2	log	log	NOUN
admet-761	173	3	kp	kp	PROPN
admet-761	173	4	data	datum	NOUN
admet-761	173	5	were	be	AUX
admet-761	173	6	collected	collect	VERB
admet-761	173	7	from	from	ADP
admet-761	173	8	zhang	zhang	PROPN
admet-761	173	9	et	et	PROPN
admet-761	173	10	.	.	PUNCT
admet-761	174	1	al	al	PROPN
admet-761	174	2	.	.	PROPN
admet-761	174	3	database	database	PROPN
admet-761	175	1	[	[	X
admet-761	175	2	18	18	NUM
admet-761	175	3	]	]	PUNCT
admet-761	175	4	.	.	PUNCT
admet-761	176	1	table	table	NOUN
admet-761	176	2	3	3	NUM
admet-761	176	3	shows	show	VERB
admet-761	176	4	the	the	DET
admet-761	176	5	log	log	NOUN
admet-761	176	6	kp	kp	PROPN
admet-761	176	7	and	and	CCONJ
admet-761	176	8	log	log	VERB
admet-761	176	9	pe	pe	PROPN
admet-761	176	10	values	value	NOUN
admet-761	176	11	of	of	ADP
admet-761	176	12	the	the	DET
admet-761	176	13	compounds	compound	NOUN
admet-761	176	14	used	use	VERB
admet-761	176	15	in	in	ADP
admet-761	176	16	the	the	DET
admet-761	176	17	correlation	correlation	NOUN
admet-761	176	18	.	.	PUNCT
admet-761	177	1	each	each	DET
admet-761	177	2	compound	compound	NOUN
admet-761	177	3	was	be	AUX
admet-761	177	4	measured	measure	VERB
admet-761	177	5	at	at	ADP
admet-761	177	6	the	the	DET
admet-761	177	7	ph	ph	NOUN
admet-761	177	8	corresponding	corresponding	NOUN
admet-761	177	9	to	to	ADP
admet-761	177	10	the	the	DET
admet-761	177	11	neutral	neutral	ADJ
admet-761	177	12	form	form	NOUN
admet-761	177	13	.	.	PUNCT
admet-761	178	1	figure	figure	VERB
admet-761	178	2	4	4	NUM
admet-761	178	3	plots	plot	NOUN
admet-761	178	4	the	the	DET
admet-761	178	5	log	log	NOUN
admet-761	178	6	kp	kp	PROPN
admet-761	178	7	vs.	vs.	ADP
admet-761	178	8	the	the	DET
admet-761	178	9	log	log	NOUN
admet-761	178	10	pe	pe	INTJ
admet-761	178	11	values	value	NOUN
admet-761	178	12	whose	whose	DET
admet-761	178	13	correlation	correlation	NOUN
admet-761	178	14	is	be	AUX
admet-761	178	15	presented	present	VERB
admet-761	178	16	in	in	ADP
admet-761	178	17	eq	eq	ADP
admet-761	178	18	.	.	PUNCT
admet-761	179	1	(	(	PUNCT
admet-761	179	2	7	7	NUM
admet-761	179	3	):	):	PUNCT
admet-761	179	4	log	log	NOUN
admet-761	179	5	kp	kp	NOUN
admet-761	179	6	=	=	SYM
admet-761	179	7	0.143(±0.403	0.143(±0.403	NUM
admet-761	179	8	)	)	PUNCT
admet-761	180	1	+	+	CCONJ
admet-761	180	2	1.156(±0.080	1.156(±0.080	X
admet-761	180	3	)	)	PUNCT
admet-761	180	4	log	log	VERB
admet-761	180	5	pe	pe	INTJ
admet-761	180	6	(	(	PUNCT
admet-761	180	7	7	7	NUM
admet-761	180	8	)	)	PUNCT
admet-761	180	9	n	n	NOUN
admet-761	180	10	=	=	SYM
admet-761	180	11	46	46	NUM
admet-761	180	12	r2	r2	NOUN
admet-761	180	13	=	=	PUNCT
admet-761	180	14	0.826	0.826	NUM
admet-761	180	15	sd	sd	ADP
admet-761	180	16	=	=	PUNCT
admet-761	180	17	0.434	0.434	NUM
admet-761	180	18	f	f	X
admet-761	180	19	=	=	SYM
admet-761	180	20	208	208	NUM
admet-761	180	21	a	a	DET
admet-761	180	22	good	good	ADJ
admet-761	180	23	correlation	correlation	NOUN
admet-761	180	24	between	between	ADP
admet-761	180	25	human	human	ADJ
admet-761	180	26	skin	skin	NOUN
admet-761	180	27	and	and	CCONJ
admet-761	180	28	skin	skin	NOUN
admet-761	180	29	-	-	PUNCT
admet-761	180	30	pampa	pampa	NOUN
admet-761	180	31	data	datum	NOUN
admet-761	180	32	and	and	CCONJ
admet-761	180	33	adequate	adequate	ADJ
admet-761	180	34	statistical	statistical	ADJ
admet-761	180	35	parameters	parameter	NOUN
admet-761	180	36	have	have	AUX
admet-761	180	37	been	be	AUX
admet-761	180	38	obtained	obtain	VERB
admet-761	180	39	.	.	PUNCT
admet-761	181	1	figure	figure	NOUN
admet-761	181	2	3	3	NUM
admet-761	181	3	.	.	PUNCT
admet-761	181	4	influence	influence	NOUN
admet-761	181	5	of	of	ADP
admet-761	181	6	treatment	treatment	NOUN
admet-761	181	7	time	time	NOUN
admet-761	181	8	and	and	CCONJ
admet-761	181	9	ph	ph	NOUN
admet-761	181	10	in	in	ADP
admet-761	181	11	skin	skin	NOUN
admet-761	181	12	-	-	PUNCT
admet-761	181	13	pampa	pampa	NOUN
admet-761	181	14	permeability	permeability	NOUN
admet-761	181	15	.	.	PUNCT
admet-761	182	1	treatment	treatment	NOUN
admet-761	182	2	time	time	NOUN
admet-761	182	3	:	:	PUNCT
admet-761	182	4	30	30	NUM
admet-761	182	5	minutes	minute	NOUN
admet-761	182	6	(	(	PUNCT
admet-761	182	7	▲	▲	PUNCT
admet-761	182	8	)	)	PUNCT
admet-761	182	9	;	;	PUNCT
admet-761	182	10	4	4	NUM
admet-761	182	11	hours	hour	NOUN
admet-761	182	12	(	(	PUNCT
admet-761	182	13	∎	∎	PROPN
admet-761	182	14	)	)	PUNCT
admet-761	182	15	.	.	PUNCT
admet-761	183	1	table	table	NOUN
admet-761	183	2	3	3	NUM
admet-761	183	3	.	.	X
admet-761	184	1	log	log	PROPN
admet-761	184	2	kp	kp	PROPN
admet-761	184	3	and	and	CCONJ
admet-761	184	4	log	log	VERB
admet-761	184	5	pe	pe	INTJ
admet-761	184	6	experimental	experimental	ADJ
admet-761	184	7	values	value	NOUN
admet-761	184	8	of	of	ADP
admet-761	184	9	the	the	DET
admet-761	184	10	neutral	neutral	ADJ
admet-761	184	11	form	form	NOUN
admet-761	184	12	of	of	ADP
admet-761	184	13	the	the	DET
admet-761	184	14	drugs	drug	NOUN
admet-761	184	15	.	.	PUNCT
admet-761	185	1	both	both	CCONJ
admet-761	185	2	kp	kp	PROPN
admet-761	185	3	and	and	CCONJ
admet-761	185	4	pe	pe	VERB
admet-761	185	5	in	in	ADP
admet-761	185	6	cm	cm	PROPN
admet-761	185	7	/	/	SYM
admet-761	185	8	s	s	PART
admet-761	185	9	units	unit	NOUN
admet-761	185	10	.	.	PUNCT
admet-761	186	1	solutes	solute	NOUN
admet-761	186	2	log	log	VERB
admet-761	186	3	kp	kp	PROPN
admet-761	187	1	[	[	X
admet-761	187	2	18	18	NUM
admet-761	187	3	]	]	X
admet-761	187	4	log	log	NOUN
admet-761	187	5	pe	pe	NOUN
admet-761	187	6	2,4	2,4	NUM
admet-761	187	7	-	-	PUNCT
admet-761	187	8	dichlorophenol	dichlorophenol	NOUN
admet-761	187	9	-4.30	-4.30	PUNCT
admet-761	187	10	-3.92±	-3.92±	PROPN
admet-761	187	11	0.00	0.00	NUM
admet-761	187	12	2	2	NUM
admet-761	187	13	-	-	PUNCT
admet-761	187	14	isopropyl-5	isopropyl-5	NOUN
admet-761	187	15	-	-	PUNCT
admet-761	187	16	methylphenol	methylphenol	NOUN
admet-761	187	17	(	(	PUNCT
admet-761	187	18	thymol	thymol	NOUN
admet-761	187	19	)	)	PUNCT
admet-761	187	20	-4.35	-4.35	NUM
admet-761	187	21	-4.01±	-4.01±	NOUN
admet-761	187	22	0.00	0.00	NUM
admet-761	187	23	2	2	NUM
admet-761	187	24	-	-	PUNCT
admet-761	187	25	nitro	nitro	NOUN
admet-761	187	26	-	-	PUNCT
admet-761	187	27	p	p	NOUN
admet-761	187	28	-	-	PUNCT
admet-761	187	29	phenylenediamine	phenylenediamine	NOUN
admet-761	187	30	-6.66	-6.66	ADP
admet-761	187	31	-5.25±0.02	-5.25±0.02	NOUN
admet-761	187	32	3	3	NUM
admet-761	187	33	-	-	PUNCT
admet-761	187	34	methylphenol	methylphenol	NOUN
admet-761	187	35	(	(	PUNCT
admet-761	187	36	m	m	NOUN
admet-761	187	37	-	-	PUNCT
admet-761	187	38	cresol	cresol	NOUN
admet-761	187	39	)	)	PUNCT
admet-761	187	40	-4.89	-4.89	NUM
admet-761	187	41	-4.33±0.01	-4.33±0.01	NUM
admet-761	187	42	4	4	NUM
admet-761	187	43	-	-	PUNCT
admet-761	187	44	amino-2	amino-2	NUM
admet-761	187	45	-	-	PUNCT
admet-761	187	46	nitrophenol	nitrophenol	NOUN
admet-761	187	47	-5.91	-5.91	NOUN
admet-761	187	48	-4.59±0.02	-4.59±0.02	NOUN
admet-761	187	49	4	4	NUM
admet-761	187	50	-	-	PUNCT
admet-761	187	51	chlorophenol	chlorophenol	NOUN
admet-761	187	52	-4.52	-4.52	NOUN
admet-761	187	53	-4.270.02±	-4.270.02±	PUNCT
admet-761	187	54	4	4	NUM
admet-761	187	55	-	-	PUNCT
admet-761	187	56	ethylphenol	ethylphenol	NOUN
admet-761	187	57	-4.53	-4.53	NOUN
admet-761	187	58	-4.19±0.02	-4.19±0.02	NOUN
admet-761	187	59	4	4	NUM
admet-761	187	60	-	-	PUNCT
admet-761	187	61	hydroxyphenylacetamide	hydroxyphenylacetamide	NOUN
admet-761	187	62	-6.89	-6.89	NOUN
admet-761	187	63	-6.07±0.08	-6.07±0.08	PROPN
admet-761	187	64	4	4	NUM
admet-761	187	65	-	-	PUNCT
admet-761	187	66	hydroxy	hydroxy	VERB
admet-761	187	67	-	-	PUNCT
admet-761	187	68	methylphenylacetate	methylphenylacetate	NOUN
admet-761	187	69	-5.26	-5.26	ADJ
admet-761	187	70	-5.07±0.09	-5.07±0.09	ADJ
admet-761	187	71	4	4	NUM
admet-761	187	72	-	-	PUNCT
admet-761	187	73	nitrophenol	nitrophenol	NOUN
admet-761	187	74	-5.33	-5.33	PROPN
admet-761	187	75	-4.91±0.02	-4.91±0.02	PROPN
admet-761	187	76	5	5	NUM
admet-761	187	77	-	-	PUNCT
admet-761	187	78	fluorouracil	fluorouracil	NOUN
admet-761	187	79	-6.82	-6.82	NUM
admet-761	187	80	-5.77±0.02	-5.77±0.02	ADJ
admet-761	187	81	8	8	NUM
admet-761	187	82	-	-	PUNCT
admet-761	187	83	methoxypsoralen	methoxypsoralen	VERB
admet-761	187	84	-5.12	-5.12	NOUN
admet-761	187	85	-4.30±0.03	-4.30±0.03	PROPN
admet-761	187	86	5,5	5,5	NUM
admet-761	187	87	-	-	PUNCT
admet-761	187	88	diethylbarbituric	diethylbarbituric	ADJ
admet-761	187	89	acid	acid	NOUN
admet-761	187	90	(	(	PUNCT
admet-761	187	91	barbital	barbital	ADJ
admet-761	187	92	)	)	PUNCT
admet-761	187	93	-7.29	-7.29	NOUN
admet-761	187	94	-5.75±0.05	-5.75±0.05	PUNCT
admet-761	187	95	5	5	NUM
admet-761	187	96	-	-	PUNCT
admet-761	187	97	ethyl-5	ethyl-5	NUM
admet-761	187	98	-	-	PUNCT
admet-761	187	99	phenylbarbituric	phenylbarbituric	NOUN
admet-761	187	100	acid	acid	NOUN
admet-761	187	101	(	(	PUNCT
admet-761	187	102	phenobarbital	phenobarbital	ADJ
admet-761	187	103	)	)	PUNCT
admet-761	187	104	-6.68	-6.68	NUM
admet-761	187	105	-6.05±0.01	-6.05±0.01	PROPN
admet-761	187	106	benzoic	benzoic	NOUN
admet-761	187	107	acid	acid	NOUN
admet-761	187	108	-5.68	-5.68	NOUN
admet-761	187	109	-4.82±0.07	-4.82±0.07	PUNCT
admet-761	187	110	4	4	NUM
admet-761	187	111	-	-	PUNCT
admet-761	187	112	hydroxybenzyl	hydroxybenzyl	NOUN
admet-761	187	113	alcohol	alcohol	NOUN
admet-761	187	114	-6.26	-6.26	PROPN
admet-761	187	115	-5.85±0.01	-5.85±0.01	ADJ
admet-761	187	116	aminopyrine	aminopyrine	NOUN
admet-761	187	117	-6.55	-6.55	CCONJ
admet-761	187	118	-5.67±0.03	-5.67±0.03	PROPN
admet-761	187	119	aniline	aniline	ADJ
admet-761	187	120	-4.94	-4.94	ADJ
admet-761	187	121	-4.55±0.00	-4.55±0.00	NOUN
admet-761	187	122	benzyl	benzyl	NOUN
admet-761	187	123	nicotinate	nicotinate	NOUN
admet-761	187	124	-4.87	-4.87	PUNCT
admet-761	187	125	-4.16±0.02	-4.16±0.02	ADJ
admet-761	187	126	caffeine	caffeine	NOUN
admet-761	187	127	-6.85	-6.85	NUM
admet-761	187	128	-5.45±0.02	-5.45±0.02	PUNCT
admet-761	187	129	catechol	catechol	NOUN
admet-761	187	130	-5.87	-5.87	INTJ
admet-761	187	131	-5.39±0.00	-5.39±0.00	NUM
admet-761	187	132	cortexolone	cortexolone	NOUN
admet-761	187	133	-7.20	-7.20	NUM
admet-761	187	134	-5.45±0.03	-5.45±0.03	PROPN
admet-761	187	135	corticosterone	corticosterone	NOUN
admet-761	187	136	-6.84	-6.84	NOUN
admet-761	187	137	-5.59±0.01	-5.59±0.01	NOUN
admet-761	187	138	cortisone	cortisone	PROPN
admet-761	187	139	-7.38	-7.38	PROPN
admet-761	187	140	-6.09±0.02	-6.09±0.02	PROPN
admet-761	187	141	dexamethasone	dexamethasone	PROPN
admet-761	187	142	-7.27	-7.27	PROPN
admet-761	187	143	-6.25±0.03	-6.25±0.03	PROPN
admet-761	187	144	diclofenac	diclofenac	NOUN
admet-761	187	145	-5.30	-5.30	PRON
admet-761	187	146	-3.79±0.02	-3.79±0.02	PROPN
admet-761	187	147	digitoxin	digitoxin	PROPN
admet-761	187	148	-8.15	-8.15	PROPN
admet-761	187	149	-6.38±0.15	-6.38±0.15	PROPN
admet-761	187	150	estradiol	estradiol	PROPN
admet-761	187	151	-5.61	-5.61	CCONJ
admet-761	187	152	-4.15±0.07	-4.15±0.07	NOUN
admet-761	187	153	fluocinonide	fluocinonide	NOUN
admet-761	187	154	-6.33	-6.33	NOUN
admet-761	187	155	-5.38±0.06	-5.38±0.06	ADP
admet-761	187	156	flurbiprofen	flurbiprofen	NOUN
admet-761	187	157	-4.72	-4.72	NOUN
admet-761	187	158	-3.69±0.01	-3.69±0.01	NOUN
admet-761	187	159	griseofulvin	griseofulvin	NOUN
admet-761	187	160	-6.44	-6.44	SYM
admet-761	187	161	-5.28±0.06	-5.28±0.06	NOUN
admet-761	187	162	hydrocortisone	hydrocortisone	PROPN
admet-761	187	163	-7.22	-7.22	PROPN
admet-761	187	164	-6.17±0.05	-6.17±0.05	PROPN
admet-761	187	165	hydroquinone	hydroquinone	PROPN
admet-761	187	166	-6.31	-6.31	PRON
admet-761	187	167	-5.87±0.06	-5.87±0.06	PUNCT
admet-761	187	168	hydroxyprogesterone	hydroxyprogesterone	ADJ
admet-761	187	169	-6.30	-6.30	PROPN
admet-761	187	170	-4.70±0.05	-4.70±0.05	ADV
admet-761	187	171	ibuprofen	ibuprofen	NOUN
admet-761	187	172	-4.58	-4.58	NOUN
admet-761	187	173	-3.61±0.06	-3.61±0.06	PUNCT
admet-761	187	174	indomethacine	indomethacine	NOUN
admet-761	187	175	-5.39	-5.39	PRON
admet-761	187	176	-4.40±0.04	-4.40±0.04	PROPN
admet-761	187	177	isoquinoline	isoquinoline	PROPN
admet-761	187	178	-5.11	-5.11	NOUN
admet-761	187	179	-4.20±0.01	-4.20±0.01	ADJ
admet-761	187	180	ketoprofen	ketoprofen	VERB
admet-761	187	181	-5.22	-5.22	NUM
admet-761	187	182	-4.68±0.03	-4.68±0.03	NOUN
admet-761	187	183	methyl	methyl	NOUN
admet-761	187	184	4	4	NUM
admet-761	187	185	-	-	PUNCT
admet-761	187	186	hydroxybenzoate	hydroxybenzoate	NOUN
admet-761	187	187	-5.12	-5.12	NOUN
admet-761	187	188	-4.88±0.04	-4.88±0.04	ADJ
admet-761	187	189	methyl	methyl	NOUN
admet-761	187	190	phenyl	phenyl	NOUN
admet-761	187	191	ether	ether	NOUN
admet-761	187	192	(	(	PUNCT
admet-761	187	193	anisole	anisole	NOUN
admet-761	187	194	)	)	PUNCT
admet-761	187	195	-4.68	-4.68	PROPN
admet-761	187	196	-4.34±0.04	-4.34±0.04	PUNCT
admet-761	187	197	naproxen	naproxen	PROPN
admet-761	187	198	-4.97	-4.97	PROPN
admet-761	187	199	-4.19±0.04	-4.19±0.04	PUNCT
admet-761	187	200	o	o	NOUN
admet-761	187	201	-	-	NOUN
admet-761	187	202	phenylenediamine	phenylenediamine	ADJ
admet-761	187	203	-6.70	-6.70	PRON
admet-761	187	204	-5.42±0.02	-5.42±0.02	NUM
admet-761	187	205	piroxicam	piroxicam	PROPN
admet-761	187	206	-6.02	-6.02	PROPN
admet-761	187	207	-4.67±0.05	-4.67±0.05	NOUN
admet-761	187	208	prednisolone	prednisolone	PROPN
admet-761	187	209	-7.91	-7.91	X
admet-761	187	210	-6.42±0.02	-6.42±0.02	PROPN
admet-761	187	211	progesterone	progesterone	NOUN
admet-761	187	212	-4.90	-4.90	DET
admet-761	187	213	-4.13±0.02	-4.13±0.02	NOUN
admet-761	187	214	testosterone	testosterone	NOUN
admet-761	187	215	-5.54	-5.54	PROPN
admet-761	187	216	-4.52±0.03	-4.52±0.03	PROPN
admet-761	187	217	conclusions	conclusion	NOUN
admet-761	187	218	the	the	DET
admet-761	187	219	tests	test	NOUN
admet-761	187	220	performed	perform	VERB
admet-761	187	221	in	in	ADP
admet-761	187	222	this	this	DET
admet-761	187	223	work	work	NOUN
admet-761	187	224	indicate	indicate	VERB
admet-761	187	225	that	that	SCONJ
admet-761	187	226	the	the	DET
admet-761	187	227	ideal	ideal	NOUN
admet-761	187	228	assay	assay	VERB
admet-761	187	229	conditions	condition	NOUN
admet-761	187	230	for	for	ADP
admet-761	187	231	skin	skin	NOUN
admet-761	187	232	-	-	PUNCT
admet-761	187	233	pampa	pampa	NOUN
admet-761	187	234	permeability	permeability	NOUN
admet-761	187	235	measurements	measurement	NOUN
admet-761	187	236	are	be	AUX
admet-761	187	237	4	4	NUM
admet-761	187	238	hours	hour	NOUN
admet-761	187	239	of	of	ADP
admet-761	187	240	incubation	incubation	NOUN
admet-761	187	241	time	time	NOUN
admet-761	187	242	and	and	CCONJ
admet-761	187	243	with	with	ADP
admet-761	187	244	the	the	DET
admet-761	187	245	use	use	NOUN
admet-761	187	246	of	of	ADP
admet-761	187	247	stirring	stirring	NOUN
admet-761	187	248	.	.	PUNCT
admet-761	188	1	this	this	DET
admet-761	188	2	incubation	incubation	NOUN
admet-761	188	3	time	time	NOUN
admet-761	188	4	allows	allow	VERB
admet-761	188	5	the	the	DET
admet-761	188	6	determination	determination	NOUN
admet-761	188	7	of	of	ADP
admet-761	188	8	permeability	permeability	NOUN
admet-761	188	9	of	of	ADP
admet-761	188	10	the	the	DET
admet-761	188	11	greatest	great	ADJ
admet-761	188	12	number	number	NOUN
admet-761	188	13	of	of	ADP
admet-761	188	14	compounds	compound	NOUN
admet-761	188	15	while	while	SCONJ
admet-761	188	16	stirring	stir	VERB
admet-761	188	17	diminishes	diminish	VERB
admet-761	188	18	the	the	DET
admet-761	188	19	thickness	thickness	NOUN
admet-761	188	20	of	of	ADP
admet-761	188	21	the	the	DET
admet-761	188	22	aqueous	aqueous	ADJ
admet-761	188	23	boundary	boundary	ADJ
admet-761	188	24	layer	layer	NOUN
admet-761	188	25	.	.	PUNCT
admet-761	189	1	concerning	concern	VERB
admet-761	189	2	membrane	membrane	NOUN
admet-761	189	3	retention	retention	NOUN
admet-761	189	4	,	,	PUNCT
admet-761	189	5	this	this	DET
admet-761	189	6	parameter	parameter	NOUN
admet-761	189	7	is	be	AUX
admet-761	189	8	in	in	ADP
admet-761	189	9	general	general	ADJ
admet-761	189	10	low	low	ADJ
admet-761	189	11	(	(	PUNCT
admet-761	189	12	0	0	NUM
admet-761	189	13	-	-	NUM
admet-761	189	14	0.30	0.30	NUM
admet-761	189	15	)	)	PUNCT
admet-761	189	16	.	.	PUNCT
admet-761	190	1	it	it	PRON
admet-761	190	2	has	have	AUX
admet-761	190	3	been	be	AUX
admet-761	190	4	observed	observe	VERB
admet-761	190	5	that	that	SCONJ
admet-761	190	6	the	the	DET
admet-761	190	7	membrane	membrane	NOUN
admet-761	190	8	retention	retention	NOUN
admet-761	190	9	depends	depend	VERB
admet-761	190	10	on	on	ADP
admet-761	190	11	the	the	DET
admet-761	190	12	incubation	incubation	NOUN
admet-761	190	13	time	time	NOUN
admet-761	190	14	and	and	CCONJ
admet-761	190	15	also	also	ADV
admet-761	190	16	is	be	AUX
admet-761	190	17	related	relate	VERB
admet-761	190	18	to	to	ADP
admet-761	190	19	the	the	DET
admet-761	190	20	lipophilicity	lipophilicity	NOUN
admet-761	190	21	of	of	ADP
admet-761	190	22	compounds	compound	NOUN
admet-761	190	23	when	when	SCONJ
admet-761	190	24	they	they	PRON
admet-761	190	25	are	be	AUX
admet-761	190	26	in	in	ADP
admet-761	190	27	their	their	PRON
admet-761	190	28	neutral	neutral	ADJ
admet-761	190	29	form	form	NOUN
admet-761	190	30	.	.	PUNCT
admet-761	191	1	on	on	ADP
admet-761	191	2	the	the	DET
admet-761	191	3	other	other	ADJ
admet-761	191	4	hand	hand	NOUN
admet-761	191	5	,	,	PUNCT
admet-761	191	6	it	it	PRON
admet-761	191	7	has	have	AUX
admet-761	191	8	been	be	AUX
admet-761	191	9	demonstrated	demonstrate	VERB
admet-761	191	10	that	that	SCONJ
admet-761	191	11	the	the	DET
admet-761	191	12	skin	skin	NOUN
admet-761	191	13	-	-	PUNCT
admet-761	191	14	pampa	pampa	NOUN
admet-761	191	15	membrane	membrane	NOUN
admet-761	191	16	is	be	AUX
admet-761	191	17	affected	affect	VERB
admet-761	191	18	at	at	ADP
admet-761	191	19	basic	basic	ADJ
admet-761	191	20	ph	ph	ADJ
admet-761	191	21	values	value	NOUN
admet-761	191	22	,	,	PUNCT
admet-761	191	23	so	so	SCONJ
admet-761	191	24	it	it	PRON
admet-761	191	25	is	be	AUX
admet-761	191	26	advisable	advisable	ADJ
admet-761	191	27	to	to	PART
admet-761	191	28	perform	perform	VERB
admet-761	191	29	experiments	experiment	NOUN
admet-761	191	30	below	below	ADP
admet-761	191	31	ph	ph	NOUN
admet-761	191	32	8	8	NUM
admet-761	191	33	to	to	PART
admet-761	191	34	avoid	avoid	VERB
admet-761	191	35	damaging	damage	VERB
admet-761	191	36	the	the	DET
admet-761	191	37	membrane	membrane	NOUN
admet-761	191	38	.	.	PUNCT
admet-761	192	1	the	the	DET
admet-761	192	2	results	result	NOUN
admet-761	192	3	shown	show	VERB
admet-761	192	4	here	here	ADV
admet-761	192	5	indicate	indicate	VERB
admet-761	192	6	good	good	ADJ
admet-761	192	7	agreement	agreement	NOUN
admet-761	192	8	between	between	ADP
admet-761	192	9	human	human	ADJ
admet-761	192	10	skin	skin	NOUN
admet-761	192	11	permeability	permeability	NOUN
admet-761	192	12	and	and	CCONJ
admet-761	192	13	skin	skin	NOUN
admet-761	192	14	-	-	PUNCT
admet-761	192	15	pampa	pampa	NOUN
admet-761	192	16	permeability	permeability	NOUN
admet-761	192	17	established	establish	VERB
admet-761	192	18	under	under	ADP
admet-761	192	19	appropriate	appropriate	ADJ
admet-761	192	20	assay	assay	NOUN
admet-761	192	21	conditions	condition	NOUN
admet-761	192	22	.	.	PUNCT
admet-761	193	1	figure	figure	VERB
admet-761	193	2	4	4	NUM
admet-761	193	3	.	.	PUNCT
admet-761	193	4	correlation	correlation	NOUN
admet-761	193	5	between	between	ADP
admet-761	193	6	human	human	ADJ
admet-761	193	7	skin	skin	NOUN
admet-761	193	8	permeability	permeability	NOUN
admet-761	193	9	and	and	CCONJ
admet-761	193	10	skin	skin	NOUN
admet-761	193	11	-	-	PUNCT
admet-761	193	12	pampa	pampa	NOUN
admet-761	193	13	permeability	permeability	NOUN
admet-761	193	14	.	.	PUNCT
admet-761	194	1	acknowledgements	acknowledgement	NOUN
admet-761	194	2	financial	financial	ADJ
admet-761	194	3	support	support	NOUN
admet-761	194	4	from	from	ADP
admet-761	194	5	the	the	DET
admet-761	194	6	generalitat	generalitat	PROPN
admet-761	194	7	de	de	PROPN
admet-761	194	8	catalunya	catalunya	PROPN
admet-761	194	9	(	(	PUNCT
admet-761	194	10	project	project	NOUN
admet-761	194	11	di-2014	di-2014	PROPN
admet-761	194	12	modality	modality	NOUN
admet-761	194	13	di	di	NOUN
admet-761	194	14	-	-	NOUN
admet-761	194	15	esp	esp	ADJ
admet-761	194	16	,	,	PUNCT
admet-761	194	17	resolution	resolution	NOUN
admet-761	194	18	eco/1426/2014	eco/1426/2014	NOUN
admet-761	194	19	)	)	PUNCT
admet-761	194	20	,	,	PUNCT
admet-761	194	21	the	the	DET
admet-761	194	22	ministerio	ministerio	PROPN
admet-761	194	23	de	de	PROPN
admet-761	194	24	economía	economía	PROPN
admet-761	194	25	y	y	PROPN
admet-761	194	26	competitividad	competitividad	PROPN
admet-761	194	27	from	from	ADP
admet-761	194	28	the	the	DET
admet-761	194	29	spanish	spanish	ADJ
admet-761	194	30	government	government	NOUN
admet-761	194	31	(	(	PUNCT
admet-761	194	32	ctq2017	ctq2017	NOUN
admet-761	194	33	-	-	PUNCT
admet-761	194	34	88179	88179	NUM
admet-761	194	35	-	-	PUNCT
admet-761	194	36	p	p	NOUN
admet-761	194	37	)	)	PUNCT
admet-761	194	38	and	and	CCONJ
admet-761	194	39	the	the	DET
admet-761	194	40	catalan	catalan	NOUN
admet-761	194	41	government	government	NOUN
admet-761	194	42	(	(	PUNCT
admet-761	194	43	2017	2017	NUM
admet-761	194	44	sgr	sgr	PROPN
admet-761	194	45	1074	1074	NUM
admet-761	194	46	)	)	PUNCT
admet-761	194	47	is	be	AUX
admet-761	194	48	acknowledged	acknowledge	VERB
admet-761	194	49	.	.	PUNCT
admet-761	195	1	authors	author	NOUN
admet-761	195	2	also	also	ADV
admet-761	195	3	acknowledge	acknowledge	VERB
admet-761	195	4	an	an	DET
admet-761	195	5	anonymous	anonymous	ADJ
admet-761	195	6	reviewer	reviewer	NOUN
admet-761	195	7	for	for	ADP
admet-761	195	8	the	the	DET
admet-761	195	9	fruitful	fruitful	ADJ
admet-761	195	10	discussions	discussion	NOUN
admet-761	195	11	regarding	regard	VERB
admet-761	195	12	membrane	membrane	NOUN
admet-761	195	13	retention	retention	NOUN
admet-761	195	14	and	and	CCONJ
admet-761	195	15	derivation	derivation	NOUN
admet-761	195	16	of	of	ADP
admet-761	195	17	equation	equation	NOUN
admet-761	195	18	6	6	NUM
admet-761	195	19	(	(	PUNCT
admet-761	195	20	appendix	appendix	NOUN
admet-761	195	21	)	)	PUNCT
admet-761	195	22	.	.	PUNCT
admet-761	196	1	conflict	conflict	NOUN
admet-761	196	2	of	of	ADP
admet-761	196	3	interest	interest	NOUN
admet-761	196	4	:	:	PUNCT
admet-761	196	5	the	the	DET
admet-761	196	6	authors	author	NOUN
admet-761	196	7	declare	declare	VERB
admet-761	196	8	no	no	DET
admet-761	196	9	conflict	conflict	NOUN
admet-761	196	10	of	of	ADP
admet-761	196	11	interest	interest	NOUN
admet-761	196	12	.	.	PUNCT
admet-761	197	1	references	reference	NOUN
admet-761	197	2	j.	j.	PROPN
admet-761	197	3	bouwstra	bouwstra	PROPN
admet-761	197	4	.	.	PUNCT
admet-761	198	1	structure	structure	NOUN
admet-761	198	2	of	of	ADP
admet-761	198	3	the	the	DET
admet-761	198	4	skin	skin	NOUN
admet-761	198	5	barrier	barrier	NOUN
admet-761	198	6	and	and	CCONJ
admet-761	198	7	its	its	PRON
admet-761	198	8	modulation	modulation	NOUN
admet-761	198	9	by	by	ADP
admet-761	198	10	vesicular	vesicular	ADJ
admet-761	198	11	formulations	formulation	NOUN
admet-761	198	12	.	.	PUNCT
admet-761	199	1	prog	prog	NOUN
admet-761	199	2	.	.	PUNCT
admet-761	200	1	lipid	lipid	PROPN
admet-761	200	2	res	re	NOUN
admet-761	200	3	.	.	PUNCT
admet-761	201	1	42	42	NUM
admet-761	201	2	(	(	PUNCT
admet-761	201	3	2003	2003	NUM
admet-761	201	4	)	)	PUNCT
admet-761	201	5	1–36	1–36	PROPN
admet-761	201	6	.	.	PUNCT
admet-761	202	1	t.j	t.j	PROPN
admet-761	202	2	.	.	PROPN
admet-761	202	3	franz	franz	PROPN
admet-761	202	4	.	.	PUNCT
admet-761	203	1	percutaneous	percutaneous	ADJ
admet-761	203	2	absorption	absorption	NOUN
admet-761	203	3	.	.	PUNCT
admet-761	204	1	on	on	ADP
admet-761	204	2	the	the	DET
admet-761	204	3	relevance	relevance	NOUN
admet-761	204	4	of	of	ADP
admet-761	204	5	in	in	ADP
admet-761	204	6	vitro	vitro	X
admet-761	204	7	data	datum	NOUN
admet-761	204	8	.	.	PUNCT
admet-761	205	1	j.	j.	PROPN
admet-761	205	2	invest	invest	PROPN
admet-761	205	3	.	.	PUNCT
admet-761	206	1	dermatol	dermatol	NOUN
admet-761	206	2	.	.	PUNCT
admet-761	207	1	64	64	NUM
admet-761	207	2	(	(	PUNCT
admet-761	207	3	1975	1975	NUM
admet-761	207	4	)	)	PUNCT
admet-761	208	1	190–195	190–195	NUM
admet-761	208	2	.	.	PUNCT
admet-761	208	3	m.	m.	PROPN
admet-761	208	4	kansy	kansy	PROPN
admet-761	208	5	,	,	PUNCT
admet-761	208	6	f.	f.	PROPN
admet-761	208	7	senner	senner	PROPN
admet-761	208	8	,	,	PUNCT
admet-761	208	9	k.	k.	PROPN
admet-761	208	10	gubernator	gubernator	PROPN
admet-761	208	11	.	.	PUNCT
admet-761	209	1	physicochemical	physicochemical	ADJ
admet-761	209	2	high	high	ADJ
admet-761	209	3	throughput	throughput	NOUN
admet-761	209	4	screening	screening	NOUN
admet-761	209	5	:	:	PUNCT
admet-761	209	6	parallel	parallel	ADJ
admet-761	209	7	artificial	artificial	ADJ
admet-761	209	8	membrane	membrane	NOUN
admet-761	209	9	permeation	permeation	NOUN
admet-761	209	10	assay	assay	VERB
admet-761	209	11	in	in	ADP
admet-761	209	12	the	the	DET
admet-761	209	13	description	description	NOUN
admet-761	209	14	of	of	ADP
admet-761	209	15	passive	passive	ADJ
admet-761	209	16	absorption	absorption	NOUN
admet-761	209	17	processes	process	NOUN
admet-761	209	18	.	.	PUNCT
admet-761	210	1	j.	j.	PROPN
admet-761	210	2	med	med	PROPN
admet-761	210	3	.	.	PROPN
admet-761	210	4	chem	chem	PROPN
admet-761	210	5	.	.	PUNCT
admet-761	211	1	41	41	NUM
admet-761	211	2	(	(	PUNCT
admet-761	211	3	1998	1998	NUM
admet-761	211	4	)	)	PUNCT
admet-761	211	5	1007–1010	1007–1010	NOUN
admet-761	211	6	.	.	PUNCT
admet-761	211	7	a.	a.	PROPN
admet-761	211	8	avdeef	avdeef	PROPN
admet-761	211	9	.	.	PUNCT
admet-761	212	1	absorption	absorption	NOUN
admet-761	212	2	and	and	CCONJ
admet-761	212	3	drug	drug	NOUN
admet-761	212	4	development	development	NOUN
admet-761	212	5	:	:	PUNCT
admet-761	212	6	solubility	solubility	NOUN
admet-761	212	7	,	,	PUNCT
admet-761	212	8	permeability	permeability	NOUN
admet-761	212	9	,	,	PUNCT
admet-761	212	10	and	and	CCONJ
admet-761	212	11	charge	charge	NOUN
admet-761	212	12	state	state	NOUN
admet-761	212	13	.	.	PUNCT
admet-761	213	1	john	john	PROPN
admet-761	213	2	wiley	wiley	PROPN
admet-761	213	3	&	&	CCONJ
admet-761	213	4	sons	sons	PROPN
admet-761	213	5	,	,	PUNCT
admet-761	213	6	inc	inc	PROPN
admet-761	213	7	,	,	PUNCT
admet-761	213	8	2003	2003	NUM
admet-761	213	9	.	.	PUNCT
admet-761	214	1	a.	a.	PROPN
admet-761	214	2	avdeef	avdeef	PROPN
admet-761	214	3	,	,	PUNCT
admet-761	214	4	s.	s.	PROPN
admet-761	214	5	bendels	bendels	PROPN
admet-761	214	6	,	,	PUNCT
admet-761	214	7	l.	l.	PROPN
admet-761	214	8	di	di	PROPN
admet-761	214	9	,	,	PUNCT
admet-761	214	10	b.	b.	PROPN
admet-761	214	11	faller	faller	PROPN
admet-761	214	12	,	,	PUNCT
admet-761	214	13	m.	m.	PROPN
admet-761	214	14	kansy	kansy	PROPN
admet-761	214	15	,	,	PUNCT
admet-761	214	16	k.	k.	PROPN
admet-761	214	17	sugano	sugano	PROPN
admet-761	214	18	,	,	PUNCT
admet-761	214	19	y.	y.	PROPN
admet-761	214	20	yamauchi	yamauchi	PROPN
admet-761	214	21	.	.	PUNCT
admet-761	215	1	pampa	pampa	PROPN
admet-761	215	2	—	—	PUNCT
admet-761	215	3	critical	critical	ADJ
admet-761	215	4	factors	factor	NOUN
admet-761	215	5	for	for	ADP
admet-761	215	6	better	well	ADJ
admet-761	215	7	predictions	prediction	NOUN
admet-761	215	8	of	of	ADP
admet-761	215	9	absorption	absorption	NOUN
admet-761	215	10	.	.	PUNCT
admet-761	216	1	j.	j.	PROPN
admet-761	216	2	pharm	pharm	PROPN
admet-761	216	3	.	.	PUNCT
admet-761	217	1	sci	sci	PROPN
admet-761	217	2	.	.	PROPN
admet-761	218	1	96	96	NUM
admet-761	218	2	(	(	PUNCT
admet-761	218	3	2007	2007	NUM
admet-761	218	4	)	)	PUNCT
admet-761	218	5	2893–2909	2893–2909	NOUN
admet-761	218	6	.	.	PUNCT
admet-761	218	7	a.	a.	PROPN
admet-761	218	8	avdeef	avdeef	PROPN
admet-761	218	9	,	,	PUNCT
admet-761	218	10	o.	o.	PROPN
admet-761	218	11	tsinman	tsinman	NOUN
admet-761	218	12	.	.	PUNCT
admet-761	219	1	pampa	pampa	NOUN
admet-761	219	2	—	—	PUNCT
admet-761	219	3	a	a	DET
admet-761	219	4	drug	drug	NOUN
admet-761	219	5	absorption	absorption	NOUN
admet-761	219	6	in	in	ADP
admet-761	219	7	vitro	vitro	X
admet-761	219	8	model	model	NOUN
admet-761	219	9	.	.	PUNCT
admet-761	220	1	eur	eur	PROPN
admet-761	220	2	.	.	PUNCT
admet-761	221	1	j.	j.	PROPN
admet-761	221	2	pharm	pharm	PROPN
admet-761	221	3	.	.	PUNCT
admet-761	222	1	sci	sci	PROPN
admet-761	222	2	.	.	PROPN
admet-761	222	3	28	28	NUM
admet-761	222	4	(	(	PUNCT
admet-761	222	5	2006	2006	NUM
admet-761	222	6	)	)	PUNCT
admet-761	222	7	43–50	43–50	NOUN
admet-761	222	8	.	.	PUNCT
admet-761	223	1	o.	o.	PROPN
admet-761	223	2	tsinman	tsinman	PROPN
admet-761	223	3	,	,	PUNCT
admet-761	223	4	k.	k.	PROPN
admet-761	223	5	tsinman	tsinman	PROPN
admet-761	223	6	,	,	PUNCT
admet-761	223	7	n.	n.	PROPN
admet-761	223	8	sun	sun	PROPN
admet-761	223	9	,	,	PUNCT
admet-761	223	10	a.	a.	NOUN
admet-761	223	11	avdeef	avdeef	PROPN
admet-761	223	12	.	.	PUNCT
admet-761	224	1	physicochemical	physicochemical	ADJ
admet-761	224	2	selectivity	selectivity	NOUN
admet-761	224	3	of	of	ADP
admet-761	224	4	the	the	DET
admet-761	224	5	bbb	bbb	PROPN
admet-761	224	6	microenvironment	microenvironment	NOUN
admet-761	224	7	governing	govern	VERB
admet-761	224	8	passive	passive	ADJ
admet-761	224	9	diffusion	diffusion	NOUN
admet-761	224	10	—	—	PUNCT
admet-761	224	11	matching	match	VERB
admet-761	224	12	with	with	ADP
admet-761	224	13	a	a	DET
admet-761	224	14	porcine	porcine	NOUN
admet-761	224	15	brain	brain	NOUN
admet-761	224	16	lipid	lipid	NOUN
admet-761	224	17	extract	extract	VERB
admet-761	224	18	artificial	artificial	ADJ
admet-761	224	19	membrane	membrane	NOUN
admet-761	224	20	permeability	permeability	NOUN
admet-761	224	21	model	model	NOUN
admet-761	224	22	.	.	PUNCT
admet-761	225	1	pharm	pharm	NOUN
admet-761	225	2	.	.	PUNCT
admet-761	226	1	res	re	NOUN
admet-761	226	2	.	.	PUNCT
admet-761	227	1	28	28	NUM
admet-761	227	2	(	(	PUNCT
admet-761	227	3	2011	2011	NUM
admet-761	227	4	)	)	PUNCT
admet-761	228	1	337–363	337–363	NUM
admet-761	228	2	.	.	PUNCT
admet-761	229	1	g.	g.	PROPN
admet-761	229	2	ottaviani	ottaviani	PROPN
admet-761	229	3	,	,	PUNCT
admet-761	229	4	s.	s.	PROPN
admet-761	229	5	martel	martel	PROPN
admet-761	229	6	,	,	PUNCT
admet-761	229	7	p.	p.	NOUN
admet-761	229	8	a.	a.	NOUN
admet-761	229	9	carrupt	carrupt	PROPN
admet-761	229	10	.	.	PUNCT
admet-761	230	1	parallel	parallel	ADJ
admet-761	230	2	artificial	artificial	ADJ
admet-761	230	3	membrane	membrane	NOUN
admet-761	230	4	permeability	permeability	NOUN
admet-761	230	5	assay	assay	VERB
admet-761	230	6	:	:	PUNCT
admet-761	230	7	a	a	DET
admet-761	230	8	new	new	ADJ
admet-761	230	9	membrane	membrane	NOUN
admet-761	230	10	for	for	ADP
admet-761	230	11	the	the	DET
admet-761	230	12	fast	fast	ADJ
admet-761	230	13	prediction	prediction	NOUN
admet-761	230	14	of	of	ADP
admet-761	230	15	passive	passive	ADJ
admet-761	230	16	human	human	ADJ
admet-761	230	17	skin	skin	NOUN
admet-761	230	18	permeability	permeability	NOUN
admet-761	230	19	.	.	PUNCT
admet-761	231	1	j.	j.	PROPN
admet-761	231	2	med	med	PROPN
admet-761	231	3	.	.	PROPN
admet-761	231	4	chem	chem	PROPN
admet-761	231	5	.	.	PUNCT
admet-761	232	1	49	49	NUM
admet-761	232	2	no	no	INTJ
admet-761	232	3	.	.	PROPN
admet-761	232	4	13	13	NUM
admet-761	232	5	,	,	PUNCT
admet-761	232	6	pp	pp	ADJ
admet-761	232	7	.	.	PUNCT
admet-761	233	1	3948–3954	3948–3954	NUM
admet-761	233	2	,	,	PUNCT
admet-761	233	3	2006	2006	NUM
admet-761	233	4	.	.	PUNCT
admet-761	234	1	b.	b.	PROPN
admet-761	234	2	sinkó	sinkó	PROPN
admet-761	234	3	,	,	PUNCT
admet-761	234	4	j.	j.	PROPN
admet-761	234	5	kökösi	kökösi	PROPN
admet-761	234	6	,	,	PUNCT
admet-761	234	7	a.	a.	NOUN
admet-761	234	8	avdeef	avdeef	PROPN
admet-761	234	9	,	,	PUNCT
admet-761	234	10	k.	k.	PROPN
admet-761	234	11	takács	takács	PROPN
admet-761	234	12	-	-	PUNCT
admet-761	234	13	novák	novák	PROPN
admet-761	234	14	.	.	PUNCT
admet-761	235	1	a	a	DET
admet-761	235	2	pampa	pampa	NOUN
admet-761	235	3	study	study	NOUN
admet-761	235	4	of	of	ADP
admet-761	235	5	the	the	DET
admet-761	235	6	permeability	permeability	NOUN
admet-761	235	7	-	-	PUNCT
admet-761	235	8	enhancing	enhance	VERB
admet-761	235	9	effect	effect	NOUN
admet-761	235	10	of	of	ADP
admet-761	235	11	new	new	ADJ
admet-761	235	12	ceramide	ceramide	NOUN
admet-761	235	13	analogues	analogue	NOUN
admet-761	235	14	.	.	PUNCT
admet-761	236	1	chem	chem	NOUN
admet-761	236	2	.	.	PUNCT
admet-761	237	1	biodivers	biodiver	NOUN
admet-761	237	2	.	.	PUNCT
admet-761	238	1	6	6	NUM
admet-761	238	2	(	(	PUNCT
admet-761	238	3	2009	2009	NUM
admet-761	238	4	)	)	PUNCT
admet-761	239	1	1867–1874	1867–1874	NUM
admet-761	239	2	.	.	PUNCT
admet-761	240	1	b.	b.	PROPN
admet-761	240	2	sinkó	sinkó	PROPN
admet-761	240	3	,	,	PUNCT
admet-761	240	4	t.m	t.m	PROPN
admet-761	240	5	.	.	PROPN
admet-761	240	6	garrigues	garrigues	PROPN
admet-761	240	7	,	,	PUNCT
admet-761	240	8	g.t	g.t	PROPN
admet-761	240	9	.	.	PROPN
admet-761	240	10	balogh	balogh	PROPN
admet-761	240	11	,	,	PUNCT
admet-761	240	12	z.k	z.k	PROPN
admet-761	240	13	.	.	PROPN
admet-761	240	14	nagy	nagy	PROPN
admet-761	240	15	,	,	PUNCT
admet-761	240	16	o.	o.	PROPN
admet-761	240	17	tsinman	tsinman	NOUN
admet-761	240	18	,	,	PUNCT
admet-761	240	19	a.	a.	PROPN
admet-761	240	20	avdeef	avdeef	PROPN
admet-761	240	21	,	,	PUNCT
admet-761	240	22	k.	k.	PROPN
admet-761	240	23	takács	takács	PROPN
admet-761	240	24	-	-	PUNCT
admet-761	240	25	novák	novák	NOUN
admet-761	240	26	.	.	PUNCT
admet-761	241	1	skin	skin	NOUN
admet-761	241	2	–	–	PUNCT
admet-761	241	3	pampa	pampa	PROPN
admet-761	241	4	:	:	PUNCT
admet-761	241	5	a	a	DET
admet-761	241	6	new	new	ADJ
admet-761	241	7	method	method	NOUN
admet-761	241	8	for	for	ADP
admet-761	241	9	fast	fast	ADJ
admet-761	241	10	prediction	prediction	NOUN
admet-761	241	11	of	of	ADP
admet-761	241	12	skin	skin	NOUN
admet-761	241	13	penetration	penetration	NOUN
admet-761	241	14	.	.	PUNCT
admet-761	242	1	eur	eur	PROPN
admet-761	242	2	.	.	PUNCT
admet-761	243	1	j.	j.	PROPN
admet-761	243	2	pharm	pharm	PROPN
admet-761	243	3	.	.	PUNCT
admet-761	244	1	sci	sci	PROPN
admet-761	244	2	.	.	PROPN
admet-761	245	1	45	45	NUM
admet-761	245	2	(	(	PUNCT
admet-761	245	3	2012	2012	NUM
admet-761	245	4	)	)	PUNCT
admet-761	246	1	698–707	698–707	NUM
admet-761	246	2	.	.	PUNCT
admet-761	246	3	b.	b.	PROPN
admet-761	246	4	sinkó	sinkó	PROPN
admet-761	246	5	,	,	PUNCT
admet-761	246	6	g.	g.	PROPN
admet-761	246	7	vizserálek	vizserálek	PROPN
admet-761	246	8	,	,	PUNCT
admet-761	246	9	k.	k.	PROPN
admet-761	246	10	takács	takács	PROPN
admet-761	246	11	-	-	PUNCT
admet-761	246	12	novák	novák	PROPN
admet-761	246	13	.	.	PUNCT
admet-761	247	1	skin	skin	PROPN
admet-761	247	2	pampa	pampa	PROPN
admet-761	247	3	:	:	PUNCT
admet-761	247	4	application	application	NOUN
admet-761	247	5	in	in	ADP
admet-761	247	6	practice	practice	NOUN
admet-761	247	7	.	.	PUNCT
admet-761	248	1	admet	admet	PROPN
admet-761	248	2	dmpk	dmpk	PROPN
admet-761	248	3	2	2	NUM
admet-761	248	4	(	(	PUNCT
admet-761	248	5	2014	2014	NUM
admet-761	248	6	)	)	PUNCT
admet-761	248	7	191	191	NUM
admet-761	248	8	-	-	SYM
admet-761	248	9	198	198	NUM
admet-761	248	10	.	.	PUNCT
admet-761	249	1	k.	k.	PROPN
admet-761	249	2	tsinman	tsinman	PROPN
admet-761	249	3	,	,	PUNCT
admet-761	249	4	b.	b.	PROPN
admet-761	249	5	sinkó	sinkó	PROPN
admet-761	249	6	.	.	PUNCT
admet-761	250	1	a	a	DET
admet-761	250	2	high	high	ADJ
admet-761	250	3	throughput	throughput	NOUN
admet-761	250	4	method	method	NOUN
admet-761	250	5	to	to	PART
admet-761	250	6	predict	predict	VERB
admet-761	250	7	skin	skin	NOUN
admet-761	250	8	penetration	penetration	NOUN
admet-761	250	9	and	and	CCONJ
admet-761	250	10	screen	screen	NOUN
admet-761	250	11	topical	topical	ADJ
admet-761	250	12	formulations	formulation	NOUN
admet-761	250	13	.	.	PUNCT
admet-761	251	1	cosmet	cosmet	NOUN
admet-761	251	2	.	.	PUNCT
admet-761	252	1	toilet	toilet	NOUN
admet-761	252	2	.	.	PUNCT
admet-761	253	1	128	128	NUM
admet-761	253	2	(	(	PUNCT
admet-761	253	3	2013	2013	NUM
admet-761	253	4	)	)	PUNCT
admet-761	254	1	192–199	192–199	NUM
admet-761	254	2	.	.	PUNCT
admet-761	255	1	l.	l.	PROPN
admet-761	255	2	luo	luo	PROPN
admet-761	255	3	,	,	PUNCT
admet-761	255	4	a.	a.	PROPN
admet-761	255	5	patel	patel	PROPN
admet-761	255	6	,	,	PUNCT
admet-761	255	7	b.	b.	PROPN
admet-761	255	8	sinko	sinko	PROPN
admet-761	255	9	,	,	PUNCT
admet-761	255	10	m.	m.	NOUN
admet-761	255	11	bell	bell	PROPN
admet-761	255	12	,	,	PUNCT
admet-761	255	13	j.	j.	PROPN
admet-761	255	14	wibawa	wibawa	PROPN
admet-761	255	15	,	,	PUNCT
admet-761	255	16	j.	j.	PROPN
admet-761	255	17	hadgraft	hadgraft	PROPN
admet-761	255	18	,	,	PUNCT
admet-761	255	19	m.e	m.e	PROPN
admet-761	255	20	.	.	PROPN
admet-761	255	21	lane	lane	PROPN
admet-761	255	22	.	.	PUNCT
admet-761	256	1	a	a	DET
admet-761	256	2	comparative	comparative	ADJ
admet-761	256	3	study	study	NOUN
admet-761	256	4	of	of	ADP
admet-761	256	5	the	the	DET
admet-761	256	6	in	in	ADP
admet-761	256	7	vitro	vitro	X
admet-761	256	8	permeation	permeation	NOUN
admet-761	256	9	of	of	ADP
admet-761	256	10	ibuprofen	ibuprofen	NOUN
admet-761	256	11	in	in	ADP
admet-761	256	12	mammalian	mammalian	ADJ
admet-761	256	13	skin	skin	NOUN
admet-761	256	14	,	,	PUNCT
admet-761	256	15	the	the	DET
admet-761	256	16	pampa	pampa	PROPN
admet-761	256	17	model	model	NOUN
admet-761	256	18	and	and	CCONJ
admet-761	256	19	silicone	silicone	NOUN
admet-761	256	20	membrane	membrane	NOUN
admet-761	256	21	.	.	PUNCT
admet-761	257	1	int	int	NOUN
admet-761	257	2	.	.	PUNCT
admet-761	258	1	j.	j.	PROPN
admet-761	258	2	pharm	pharm	PROPN
admet-761	258	3	.	.	PUNCT
admet-761	259	1	505	505	NUM
admet-761	259	2	(	(	PUNCT
admet-761	259	3	2016	2016	NUM
admet-761	259	4	)	)	PUNCT
admet-761	259	5	14–19	14–19	NUM
admet-761	259	6	.	.	PUNCT
admet-761	260	1	g.	g.	PROPN
admet-761	260	2	vizserálek	vizserálek	PROPN
admet-761	260	3	,	,	PUNCT
admet-761	260	4	s.	s.	PROPN
admet-761	260	5	berko	berko	PROPN
admet-761	260	6	,	,	PUNCT
admet-761	260	7	g.	g.	PROPN
admet-761	260	8	toth	toth	PROPN
admet-761	260	9	,	,	PUNCT
admet-761	260	10	r.	r.	PROPN
admet-761	260	11	balogh	balogh	PROPN
admet-761	260	12	,	,	PUNCT
admet-761	260	13	m.	m.	PROPN
admet-761	260	14	budai	budai	PROPN
admet-761	260	15	-	-	PUNCT
admet-761	260	16	szucs	szucs	PROPN
admet-761	260	17	,	,	PUNCT
admet-761	260	18	e.	e.	PROPN
admet-761	260	19	csanyi	csanyi	PROPN
admet-761	260	20	,	,	PUNCT
admet-761	260	21	b.	b.	PROPN
admet-761	260	22	sinko	sinko	PROPN
admet-761	260	23	,	,	PUNCT
admet-761	260	24	k.	k.	PROPN
admet-761	260	25	takács	takács	PROPN
admet-761	260	26	-	-	PUNCT
admet-761	260	27	novák	novák	NOUN
admet-761	260	28	.	.	PUNCT
admet-761	261	1	permeability	permeability	NOUN
admet-761	261	2	test	test	NOUN
admet-761	261	3	for	for	ADP
admet-761	261	4	transdermal	transdermal	ADJ
admet-761	261	5	and	and	CCONJ
admet-761	261	6	local	local	ADJ
admet-761	261	7	therapeutic	therapeutic	ADJ
admet-761	261	8	patches	patch	NOUN
admet-761	261	9	using	use	VERB
admet-761	261	10	skin	skin	NOUN
admet-761	261	11	pampa	pampa	PROPN
admet-761	261	12	method	method	NOUN
admet-761	261	13	.	.	PUNCT
admet-761	262	1	eur	eur	PROPN
admet-761	262	2	.	.	PUNCT
admet-761	263	1	j.	j.	PROPN
admet-761	263	2	pharm	pharm	PROPN
admet-761	263	3	.	.	PUNCT
admet-761	264	1	sci	sci	PROPN
admet-761	264	2	.	.	PROPN
admet-761	265	1	76	76	NUM
admet-761	265	2	(	(	PUNCT
admet-761	265	3	2015	2015	NUM
admet-761	265	4	)	)	PUNCT
admet-761	266	1	165–172	165–172	NUM
admet-761	266	2	.	.	PUNCT
admet-761	266	3	a.	a.	PROPN
admet-761	266	4	avdeef	avdeef	PROPN
admet-761	266	5	,	,	PUNCT
admet-761	266	6	p.	p.	PROPN
admet-761	266	7	e.	e.	PROPN
admet-761	266	8	nielsen	nielsen	PROPN
admet-761	266	9	,	,	PUNCT
admet-761	266	10	o.	o.	PROPN
admet-761	266	11	tsinman	tsinman	PROPN
admet-761	266	12	.	.	PUNCT
admet-761	267	1	pampa	pampa	NOUN
admet-761	267	2	-	-	PUNCT
admet-761	267	3	a	a	DET
admet-761	267	4	drug	drug	NOUN
admet-761	267	5	absorption	absorption	NOUN
admet-761	267	6	in	in	ADP
admet-761	267	7	vitro	vitro	X
admet-761	267	8	model	model	NOUN
admet-761	267	9	11	11	NUM
admet-761	267	10	.	.	PUNCT
admet-761	268	1	matching	match	VERB
admet-761	268	2	the	the	DET
admet-761	268	3	in	in	ADP
admet-761	268	4	vivo	vivo	ADJ
admet-761	268	5	unstirred	unstirred	ADJ
admet-761	268	6	water	water	NOUN
admet-761	268	7	layer	layer	NOUN
admet-761	268	8	thickness	thickness	NOUN
admet-761	268	9	by	by	ADP
admet-761	268	10	individual	individual	ADJ
admet-761	268	11	-	-	PUNCT
admet-761	268	12	well	well	ADV
admet-761	268	13	stirring	stirring	NOUN
admet-761	268	14	in	in	ADP
admet-761	268	15	microtitre	microtitre	NOUN
admet-761	268	16	plates	plate	NOUN
admet-761	268	17	.	.	PUNCT
admet-761	269	1	eur	eur	PROPN
admet-761	269	2	.	.	PUNCT
admet-761	270	1	j.	j.	PROPN
admet-761	270	2	pharm	pharm	PROPN
admet-761	270	3	.	.	PUNCT
admet-761	271	1	sci	sci	PROPN
admet-761	271	2	.	.	PROPN
admet-761	272	1	22	22	NUM
admet-761	272	2	(	(	PUNCT
admet-761	272	3	2004	2004	NUM
admet-761	272	4	)	)	PUNCT
admet-761	273	1	365–374	365–374	NUM
admet-761	273	2	.	.	PUNCT
admet-761	274	1	r.	r.	PROPN
admet-761	274	2	lieckfeldt	lieckfeldt	PROPN
admet-761	274	3	,	,	PUNCT
admet-761	274	4	j.	j.	PROPN
admet-761	274	5	villalaín	villalaín	PROPN
admet-761	274	6	,	,	PUNCT
admet-761	274	7	j.	j.	PROPN
admet-761	274	8	c.	c.	PROPN
admet-761	274	9	gómez	gómez	PROPN
admet-761	274	10	-	-	PUNCT
admet-761	274	11	fernández	fernández	PROPN
admet-761	274	12	,	,	PUNCT
admet-761	274	13	g.	g.	PROPN
admet-761	274	14	lee	lee	PROPN
admet-761	274	15	.	.	PUNCT
admet-761	275	1	apparent	apparent	PROPN
admet-761	275	2	pka	pka	PROPN
admet-761	275	3	of	of	ADP
admet-761	275	4	the	the	DET
admet-761	275	5	fatty	fatty	NOUN
admet-761	275	6	acids	acid	NOUN
admet-761	275	7	within	within	ADP
admet-761	275	8	ordered	order	VERB
admet-761	275	9	mixtures	mixture	NOUN
admet-761	275	10	of	of	ADP
admet-761	275	11	model	model	NOUN
admet-761	275	12	human	human	ADJ
admet-761	275	13	stratum	stratum	NOUN
admet-761	275	14	corneum	corneum	NOUN
admet-761	275	15	lipids	lipids	PROPN
admet-761	275	16	.	.	PUNCT
admet-761	276	1	pharm	pharm	NOUN
admet-761	276	2	.	.	PUNCT
admet-761	277	1	res	re	NOUN
admet-761	277	2	.	.	PROPN
admet-761	278	1	12	12	NUM
admet-761	278	2	(	(	PUNCT
admet-761	278	3	1995	1995	NUM
admet-761	278	4	)	)	PUNCT
admet-761	278	5	1614–1617	1614–1617	NUM
admet-761	278	6	.	.	PUNCT
admet-761	278	7	a.	a.	PROPN
admet-761	278	8	avdeef	avdeef	PROPN
admet-761	278	9	.	.	PUNCT
admet-761	279	1	absorption	absorption	NOUN
admet-761	279	2	and	and	CCONJ
admet-761	279	3	drug	drug	NOUN
admet-761	279	4	development	development	NOUN
admet-761	279	5	:	:	PUNCT
admet-761	279	6	solubility	solubility	NOUN
admet-761	279	7	,	,	PUNCT
admet-761	279	8	permeability	permeability	NOUN
admet-761	279	9	,	,	PUNCT
admet-761	279	10	and	and	CCONJ
admet-761	279	11	charge	charge	NOUN
admet-761	279	12	state	state	NOUN
admet-761	279	13	.	.	PUNCT
admet-761	280	1	2nd	2nd	ADJ
admet-761	280	2	ed	ed	NOUN
admet-761	280	3	.	.	PUNCT
admet-761	281	1	john	john	PROPN
admet-761	281	2	wiley	wiley	PROPN
admet-761	281	3	&	&	CCONJ
admet-761	281	4	sons	sons	PROPN
admet-761	281	5	,	,	PUNCT
admet-761	281	6	inc	inc	PROPN
admet-761	281	7	.	.	PROPN
admet-761	281	8	,	,	PUNCT
admet-761	281	9	2012	2012	NUM
admet-761	281	10	.	.	PUNCT
admet-761	282	1	k.	k.	PROPN
admet-761	282	2	zhang	zhang	PROPN
admet-761	282	3	,	,	PUNCT
admet-761	282	4	m.	m.	PROPN
admet-761	282	5	h.	h.	PROPN
admet-761	282	6	abraham	abraham	PROPN
admet-761	282	7	,	,	PUNCT
admet-761	282	8	x.	x.	PROPN
admet-761	282	9	liu	liu	PROPN
admet-761	282	10	.	.	PUNCT
admet-761	283	1	an	an	DET
admet-761	283	2	equation	equation	NOUN
admet-761	283	3	for	for	ADP
admet-761	283	4	the	the	DET
admet-761	283	5	prediction	prediction	NOUN
admet-761	283	6	of	of	ADP
admet-761	283	7	human	human	ADJ
admet-761	283	8	skin	skin	NOUN
admet-761	283	9	permeability	permeability	NOUN
admet-761	283	10	of	of	ADP
admet-761	283	11	neutral	neutral	ADJ
admet-761	283	12	molecules	molecule	NOUN
admet-761	283	13	,	,	PUNCT
admet-761	283	14	ions	ion	NOUN
admet-761	283	15	and	and	CCONJ
admet-761	283	16	ionic	ionic	ADJ
admet-761	283	17	species	specie	NOUN
admet-761	283	18	.	.	PUNCT
admet-761	284	1	int	int	NOUN
admet-761	284	2	.	.	PUNCT
admet-761	285	1	j.	j.	PROPN
admet-761	285	2	pharm	pharm	PROPN
admet-761	285	3	.	.	PUNCT
admet-761	286	1	521	521	NUM
admet-761	286	2	(	(	PUNCT
admet-761	286	3	2017	2017	NUM
admet-761	286	4	)	)	PUNCT
admet-761	286	5	259–266	259–266	NUM
admet-761	286	6	.	.	PUNCT
admet-761	286	7	bio	bio	NOUN
admet-761	286	8	-	-	NOUN
admet-761	286	9	loom	loom	NOUN
admet-761	286	10	,	,	PUNCT
admet-761	286	11	2017	2017	NUM
admet-761	286	12	.	.	PUNCT
admet-761	287	1	biobyte	biobyte	PROPN
admet-761	287	2	corp	corp	PROPN
admet-761	287	3	.	.	PROPN
admet-761	287	4	claremont	claremont	PROPN
admet-761	287	5	,	,	PUNCT
admet-761	287	6	ca	ca	PROPN
admet-761	287	7	,	,	PUNCT
admet-761	287	8	usa	usa	PROPN
admet-761	287	9	.	.	PROPN
admet-761	287	10	http://www.biobyte.com	http://www.biobyte.com	X
admet-761	287	11	.	.	PUNCT
admet-761	288	1	date	date	NOUN
admet-761	288	2	accessed	access	VERB
admet-761	288	3	:	:	PUNCT
admet-761	288	4	february	february	PROPN
admet-761	288	5	17	17	NUM
admet-761	288	6	,	,	PUNCT
admet-761	288	7	2020	2020	NUM
admet-761	288	8	.	.	PUNCT
admet-761	289	1	acd	acd	NOUN
admet-761	289	2	/	/	SYM
admet-761	289	3	percepta	percepta	NOUN
admet-761	289	4	,	,	PUNCT
admet-761	289	5	www.acdlabs.com	www.acdlabs.com	NOUN
admet-761	289	6	,	,	PUNCT
admet-761	289	7	advanced	advanced	ADJ
admet-761	289	8	chemistry	chemistry	NOUN
admet-761	289	9	development	development	NOUN
admet-761	289	10	,	,	PUNCT
admet-761	289	11	inc	inc	PROPN
admet-761	289	12	.	.	PROPN
admet-761	289	13	,	,	PUNCT
admet-761	289	14	release	release	NOUN
admet-761	289	15	(	(	PUNCT
admet-761	289	16	build	build	VERB
admet-761	289	17	2726	2726	NUM
admet-761	289	18	,	,	PUNCT
admet-761	289	19	5	5	NUM
admet-761	289	20	359	359	NUM
admet-761	289	21	may	may	PROPN
admet-761	289	22	2014	2014	NUM
admet-761	289	23	)	)	PUNCT
admet-761	289	24	.	.	PUNCT
admet-761	290	1	j.	j.	PROPN
admet-761	290	2	m.	m.	PROPN
admet-761	290	3	cabot	cabot	PROPN
admet-761	290	4	,	,	PUNCT
admet-761	290	5	e.	e.	PROPN
admet-761	290	6	fuguet	fuguet	PROPN
admet-761	290	7	,	,	PUNCT
admet-761	290	8	m.	m.	NOUN
admet-761	290	9	rosés	rosés	PROPN
admet-761	290	10	.	.	PUNCT
admet-761	291	1	determination	determination	NOUN
admet-761	291	2	of	of	ADP
admet-761	291	3	acidity	acidity	NOUN
admet-761	291	4	constants	constant	NOUN
admet-761	291	5	of	of	ADP
admet-761	291	6	sparingly	sparingly	ADV
admet-761	291	7	soluble	soluble	ADJ
admet-761	291	8	drugs	drug	NOUN
admet-761	291	9	in	in	ADP
admet-761	291	10	aqueous	aqueous	ADJ
admet-761	291	11	solution	solution	NOUN
admet-761	291	12	by	by	ADP
admet-761	291	13	the	the	DET
admet-761	291	14	internal	internal	ADJ
admet-761	291	15	standard	standard	ADJ
admet-761	291	16	capillary	capillary	ADJ
admet-761	291	17	electrophoresis	electrophoresis	NOUN
admet-761	291	18	method	method	NOUN
admet-761	291	19	.	.	PUNCT
admet-761	292	1	electrophoresis	electrophoresis	NOUN
admet-761	292	2	35	35	NUM
admet-761	292	3	(	(	PUNCT
admet-761	292	4	2014	2014	NUM
admet-761	292	5	)	)	PUNCT
admet-761	292	6	3564–3569	3564–3569	NUM
admet-761	292	7	.	.	PUNCT
admet-761	293	1	h.	h.	PROPN
admet-761	293	2	wan	wan	PROPN
admet-761	293	3	,	,	PUNCT
admet-761	293	4	a.g	a.g	PROPN
admet-761	293	5	.	.	PROPN
admet-761	293	6	holmen	holmen	PROPN
admet-761	293	7	,	,	PUNCT
admet-761	293	8	y.	y.	PROPN
admet-761	293	9	wang	wang	PROPN
admet-761	293	10	,	,	PUNCT
admet-761	293	11	w.	w.	PROPN
admet-761	293	12	lindberg	lindberg	PROPN
admet-761	293	13	,	,	PUNCT
admet-761	293	14	m.	m.	PROPN
admet-761	293	15	englund	englund	PROPN
admet-761	293	16	,	,	PUNCT
admet-761	293	17	m.b	m.b	PROPN
admet-761	293	18	.	.	PROPN
admet-761	293	19	nagard	nagard	PROPN
admet-761	293	20	,	,	PUNCT
admet-761	293	21	r.a	r.a	PROPN
admet-761	293	22	.	.	PROPN
admet-761	293	23	thompson	thompson	PROPN
admet-761	293	24	.	.	PUNCT
admet-761	294	1	high	high	ADJ
admet-761	294	2	-	-	PUNCT
admet-761	294	3	throughput	throughput	NOUN
admet-761	294	4	screening	screening	NOUN
admet-761	294	5	of	of	ADP
admet-761	294	6	pka	pka	PROPN
admet-761	294	7	values	value	NOUN
admet-761	294	8	of	of	ADP
admet-761	294	9	pharmaceuticals	pharmaceutical	NOUN
admet-761	294	10	by	by	ADP
admet-761	294	11	pressure	pressure	NOUN
admet-761	294	12	-	-	PUNCT
admet-761	294	13	assisted	assist	VERB
admet-761	294	14	capillary	capillary	ADJ
admet-761	294	15	electrophoresis	electrophoresis	NOUN
admet-761	294	16	and	and	CCONJ
admet-761	294	17	mass	mass	ADJ
admet-761	294	18	spectrometry	spectrometry	NOUN
admet-761	294	19	.	.	PUNCT
admet-761	295	1	rapid	rapid	ADJ
admet-761	295	2	commun	commun	PROPN
admet-761	295	3	.	.	PUNCT
admet-761	295	4	mass	mass	PROPN
admet-761	295	5	spectrom	spectrom	PROPN
admet-761	295	6	.	.	PUNCT
admet-761	296	1	17	17	NUM
admet-761	296	2	(	(	PUNCT
admet-761	296	3	2003	2003	NUM
admet-761	296	4	)	)	PUNCT
admet-761	296	5	2639–2648	2639–2648	NUM
admet-761	296	6	.	.	PUNCT
admet-761	297	1	a.	a.	NOUN
admet-761	297	2	port	port	NOUN
admet-761	297	3	,	,	PUNCT
admet-761	297	4	m.	m.	NOUN
admet-761	297	5	bordas	borda	NOUN
admet-761	297	6	,	,	PUNCT
admet-761	297	7	r.	r.	PROPN
admet-761	297	8	enrech	enrech	PROPN
admet-761	297	9	,	,	PUNCT
admet-761	297	10	r.	r.	PROPN
admet-761	297	11	pascual	pascual	PROPN
admet-761	297	12	,	,	PUNCT
admet-761	297	13	m.	m.	NOUN
admet-761	297	14	roses	rose	NOUN
admet-761	297	15	,	,	PUNCT
admet-761	297	16	c.	c.	PROPN
admet-761	297	17	rafols	rafols	PROPN
admet-761	297	18	,	,	PUNCT
admet-761	297	19	x.	x.	NOUN
admet-761	297	20	subirats	subirats	PROPN
admet-761	297	21	,	,	PUNCT
admet-761	297	22	e.	e.	PROPN
admet-761	297	23	bosch	bosch	PROPN
admet-761	297	24	.	.	PUNCT
admet-761	298	1	critical	critical	ADJ
admet-761	298	2	comparison	comparison	NOUN
admet-761	298	3	of	of	ADP
admet-761	298	4	shake	shake	NOUN
admet-761	298	5	-	-	PUNCT
admet-761	298	6	flask	flask	NOUN
admet-761	298	7	,	,	PUNCT
admet-761	298	8	potentiometric	potentiometric	ADJ
admet-761	298	9	and	and	CCONJ
admet-761	298	10	chromatographic	chromatographic	ADJ
admet-761	298	11	methods	method	NOUN
admet-761	298	12	for	for	ADP
admet-761	298	13	lipophilicity	lipophilicity	NOUN
admet-761	298	14	evaluation	evaluation	NOUN
admet-761	298	15	(	(	PUNCT
admet-761	298	16	log	log	VERB
admet-761	298	17	po	po	PROPN
admet-761	298	18	/	/	SYM
admet-761	298	19	w	w	NOUN
admet-761	298	20	)	)	PUNCT
admet-761	298	21	of	of	ADP
admet-761	298	22	neutral	neutral	ADJ
admet-761	298	23	,	,	PUNCT
admet-761	298	24	acidic	acidic	ADJ
admet-761	298	25	,	,	PUNCT
admet-761	298	26	basic	basic	ADJ
admet-761	298	27	,	,	PUNCT
admet-761	298	28	amphoteric	amphoteric	ADJ
admet-761	298	29	,	,	PUNCT
admet-761	298	30	and	and	CCONJ
admet-761	298	31	zwitterionic	zwitterionic	ADJ
admet-761	298	32	drugs	drug	NOUN
admet-761	298	33	.	.	PUNCT
admet-761	299	1	eur	eur	PROPN
admet-761	299	2	.	.	PUNCT
admet-761	300	1	j.	j.	PROPN
admet-761	300	2	pharm	pharm	PROPN
admet-761	300	3	.	.	PUNCT
admet-761	301	1	sci	sci	PROPN
admet-761	301	2	.	.	PROPN
admet-761	302	1	122	122	NUM
admet-761	302	2	(	(	PUNCT
admet-761	302	3	2018	2018	NUM
admet-761	302	4	)	)	PUNCT
admet-761	303	1	331–340	331–340	NUM
admet-761	303	2	.	.	PUNCT
admet-761	304	1	s.	s.	PROPN
admet-761	304	2	soriano	soriano	PROPN
admet-761	304	3	-	-	PUNCT
admet-761	304	4	meseguer	meseguer	PROPN
admet-761	304	5	,	,	PUNCT
admet-761	304	6	e.	e.	PROPN
admet-761	304	7	fuguet	fuguet	PROPN
admet-761	304	8	,	,	PUNCT
admet-761	304	9	a.	a.	NOUN
admet-761	304	10	port	port	NOUN
admet-761	304	11	,	,	PUNCT
admet-761	304	12	m.	m.	NOUN
admet-761	304	13	rosés	rosés	PROPN
admet-761	304	14	.	.	PUNCT
admet-761	305	1	estimation	estimation	NOUN
admet-761	305	2	of	of	ADP
admet-761	305	3	skin	skin	NOUN
admet-761	305	4	permeation	permeation	NOUN
admet-761	305	5	by	by	ADP
admet-761	305	6	liquid	liquid	ADJ
admet-761	305	7	chromatography	chromatography	NOUN
admet-761	305	8	.	.	PUNCT
admet-761	306	1	admet	admet	PROPN
admet-761	306	2	dmpk	dmpk	PROPN
admet-761	306	3	6	6	NUM
admet-761	306	4	(	(	PUNCT
admet-761	306	5	2018	2018	NUM
admet-761	306	6	)	)	PUNCT
admet-761	306	7	140	140	NUM
admet-761	306	8	-	-	SYM
admet-761	306	9	152	152	NUM
admet-761	306	10	.	.	PUNCT
admet-761	307	1	appendix	appendix	ADJ
admet-761	307	2	equation	equation	NOUN
admet-761	307	3	(	(	PUNCT
admet-761	307	4	6	6	NUM
admet-761	307	5	)	)	PUNCT
admet-761	307	6	can	can	AUX
admet-761	307	7	be	be	AUX
admet-761	307	8	derived	derive	VERB
admet-761	307	9	as	as	SCONJ
admet-761	307	10	follows	follow	VERB
admet-761	307	11	for	for	ADP
admet-761	307	12	a	a	DET
admet-761	307	13	drug	drug	NOUN
admet-761	307	14	equilibrated	equilibrate	VERB
admet-761	307	15	between	between	ADP
admet-761	307	16	an	an	DET
admet-761	307	17	aqueous	aqueous	ADJ
admet-761	307	18	compartment	compartment	NOUN
admet-761	307	19	and	and	CCONJ
admet-761	307	20	a	a	DET
admet-761	307	21	membrane	membrane	NOUN
admet-761	307	22	:	:	PUNCT
admet-761	307	23	therefore	therefore	ADV
admet-761	307	24	:	:	PUNCT
admet-761	307	25	because	because	SCONJ
admet-761	307	26	:	:	PUNCT
admet-761	307	27	and	and	CCONJ
admet-761	307	28	(	(	PUNCT
admet-761	307	29	6	6	X
admet-761	307	30	)	)	PUNCT
admet-761	307	31	it	it	PRON
admet-761	307	32	should	should	AUX
admet-761	307	33	be	be	AUX
admet-761	307	34	noted	note	VERB
admet-761	307	35	that	that	SCONJ
admet-761	307	36	the	the	DET
admet-761	307	37	derivation	derivation	NOUN
admet-761	307	38	assumes	assume	VERB
admet-761	307	39	that	that	SCONJ
admet-761	307	40	drug	drug	NOUN
admet-761	307	41	absorption	absorption	NOUN
admet-761	307	42	to	to	ADP
admet-761	307	43	the	the	DET
admet-761	307	44	filter	filter	NOUN
admet-761	307	45	material	material	NOUN
admet-761	307	46	can	can	AUX
admet-761	307	47	be	be	AUX
admet-761	307	48	ignored	ignore	VERB
admet-761	307	49	.	.	PUNCT
admet-761	308	1	if	if	SCONJ
admet-761	308	2	this	this	PRON
admet-761	308	3	is	be	AUX
admet-761	308	4	not	not	PART
admet-761	308	5	accurate	accurate	ADJ
admet-761	308	6	then	then	ADV
admet-761	308	7	a	a	DET
admet-761	308	8	constant	constant	ADJ
admet-761	308	9	can	can	AUX
admet-761	308	10	be	be	AUX
admet-761	308	11	added	add	VERB
admet-761	308	12	in	in	ADP
admet-761	308	13	order	order	NOUN
admet-761	308	14	to	to	PART
admet-761	308	15	improve	improve	VERB
admet-761	308	16	the	the	DET
admet-761	308	17	fit	fit	NOUN
admet-761	308	18	for	for	ADP
admet-761	308	19	less	less	ADJ
admet-761	308	20	lipophilic	lipophilic	ADJ
admet-761	308	21	compounds	compound	NOUN
admet-761	308	22	(	(	PUNCT
admet-761	308	23	equation	equation	NOUN
admet-761	308	24	6b	6b	NOUN
admet-761	308	25	)	)	PUNCT
admet-761	308	26	(	(	PUNCT
admet-761	308	27	6b	6b	NOUN
admet-761	308	28	)	)	PUNCT
admet-761	308	29	©	©	PROPN
admet-761	308	30	2020	2020	NUM
admet-761	308	31	by	by	ADP
admet-761	308	32	the	the	DET
admet-761	308	33	authors	author	NOUN
admet-761	308	34	;	;	PUNCT
admet-761	308	35	licensee	licensee	PROPN
admet-761	308	36	iapc	iapc	PROPN
admet-761	308	37	,	,	PUNCT
admet-761	308	38	zagreb	zagreb	PROPN
admet-761	308	39	,	,	PUNCT
admet-761	308	40	croatia	croatia	PROPN
admet-761	308	41	.	.	PUNCT
admet-761	309	1	this	this	DET
admet-761	309	2	article	article	NOUN
admet-761	309	3	is	be	AUX
admet-761	309	4	an	an	DET
admet-761	309	5	open	open	ADJ
admet-761	309	6	-	-	PUNCT
admet-761	309	7	access	access	NOUN
admet-761	309	8	article	article	NOUN
admet-761	309	9	distributed	distribute	VERB
admet-761	309	10	under	under	ADP
admet-761	309	11	the	the	DET
admet-761	309	12	terms	term	NOUN
admet-761	309	13	and	and	CCONJ
admet-761	309	14	conditions	condition	NOUN
admet-761	309	15	of	of	ADP
admet-761	309	16	the	the	DET
admet-761	309	17	creative	creative	ADJ
admet-761	309	18	commons	common	NOUN
admet-761	309	19	attribution	attribution	NOUN
admet-761	309	20	license	license	NOUN
admet-761	309	21	(	(	PUNCT
admet-761	309	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-761	309	23	)	)	PUNCT
admet-761	309	24	doi	doi	NOUN
admet-761	309	25	:	:	PUNCT
admet-761	309	26	http://dx.doi.org/10.5599/admet.761	http://dx.doi.org/10.5599/admet.761	ADJ
admet-761	309	27	16	16	NUM
admet-761	309	28	22	22	NUM
admet-761	309	29	doi	doi	NOUN
admet-761	309	30	:	:	PUNCT
admet-761	309	31	http://dx.doi.org/10.5599/admet.761	http://dx.doi.org/10.5599/admet.761	ADJ
admet-761	309	32	23	23	NUM
admet-761	310	1	image1.jpeg	image1.jpeg	NOUN
admet-761	310	2	image2.jpg	image2.jpg	X
admet-761	310	3	image3.jpg	image3.jpg	NOUN
admet-761	310	4	image4.jpg	image4.jpg	X
admet-761	310	5	image5.jpg	image5.jpg	NOUN
admet-761	310	6	image6.png	image6.png	PUNCT
admet-761	310	7	image7.png	image7.png	PUNCT