id	sid	tid	token	lemma	pos
admet-782	1	1	validated	validate	VERB
admet-782	1	2	hplc	hplc	NOUN
admet-782	1	3	method	method	NOUN
admet-782	1	4	for	for	ADP
admet-782	1	5	quantification	quantification	NOUN
admet-782	1	6	of	of	ADP
admet-782	1	7	copanlisib	copanlisib	PROPN
admet-782	1	8	in	in	ADP
admet-782	1	9	mice	mice	NOUN
admet-782	1	10	plasma	plasma	NOUN
admet-782	1	11	:	:	PUNCT
admet-782	1	12	application	application	NOUN
admet-782	1	13	to	to	ADP
admet-782	1	14	a	a	DET
admet-782	1	15	pharmacokinetic	pharmacokinetic	ADJ
admet-782	1	16	study	study	NOUN
admet-782	1	17	doi	doi	NOUN
admet-782	1	18	:	:	PUNCT
admet-782	1	19	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	1	20	113	113	NUM
admet-782	1	21	admet	admet	PROPN
admet-782	1	22	&	&	CCONJ
admet-782	1	23	dmpk	dmpk	PROPN
admet-782	1	24	8(1	8(1	NOUN
admet-782	1	25	)	)	PUNCT
admet-782	1	26	(	(	PUNCT
admet-782	1	27	2020	2020	NUM
admet-782	1	28	)	)	PUNCT
admet-782	1	29	113	113	NUM
admet-782	1	30	-	-	SYM
admet-782	1	31	121	121	NUM
admet-782	1	32	;	;	PUNCT
admet-782	1	33	doi	doi	NOUN
admet-782	1	34	:	:	PUNCT
admet-782	1	35	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	1	36	open	open	ADJ
admet-782	1	37	access	access	NOUN
admet-782	1	38	:	:	PUNCT
admet-782	1	39	issn	issn	PROPN
admet-782	1	40	:	:	PUNCT
admet-782	1	41	1848	1848	NUM
admet-782	1	42	-	-	SYM
admet-782	1	43	7718	7718	NUM
admet-782	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-782	1	45	original	original	ADJ
admet-782	1	46	scientific	scientific	ADJ
admet-782	1	47	paper	paper	NOUN
admet-782	1	48	validated	validate	VERB
admet-782	1	49	hplc	hplc	NOUN
admet-782	1	50	method	method	NOUN
admet-782	1	51	for	for	ADP
admet-782	1	52	quantification	quantification	NOUN
admet-782	1	53	of	of	ADP
admet-782	1	54	copanlisib	copanlisib	PROPN
admet-782	1	55	in	in	ADP
admet-782	1	56	mice	mice	NOUN
admet-782	1	57	plasma	plasma	NOUN
admet-782	1	58	:	:	PUNCT
admet-782	1	59	application	application	NOUN
admet-782	1	60	to	to	ADP
admet-782	1	61	a	a	DET
admet-782	1	62	pharmacokinetic	pharmacokinetic	ADJ
admet-782	1	63	study	study	NOUN
admet-782	1	64	ashok	ashok	NOUN
admet-782	1	65	zakkula1	zakkula1	PROPN
admet-782	1	66	,	,	PUNCT
admet-782	1	67	pavan	pavan	PROPN
admet-782	1	68	kumar	kumar	PROPN
admet-782	1	69	kurakula2	kurakula2	PROPN
admet-782	1	70	,	,	PUNCT
admet-782	1	71	sreekanth	sreekanth	ADJ
admet-782	1	72	dittakavi1	dittakavi1	NOUN
admet-782	1	73	,	,	PUNCT
admet-782	1	74	prasanthi	prasanthi	PROPN
admet-782	1	75	daram1	daram1	PROPN
admet-782	1	76	,	,	PUNCT
admet-782	1	77	ram	ram	NOUN
admet-782	1	78	murthi	murthi	NOUN
admet-782	1	79	bestha1	bestha1	NOUN
admet-782	1	80	,	,	PUNCT
admet-782	1	81	mohd	mohd	PROPN
admet-782	1	82	zainuddin1	zainuddin1	PROPN
admet-782	1	83	,	,	PUNCT
admet-782	1	84	ravi	ravi	PROPN
admet-782	1	85	kumar	kumar	PROPN
admet-782	1	86	trivedi1	trivedi1	PROPN
admet-782	1	87	,	,	PUNCT
admet-782	1	88	ramesh	ramesh	PROPN
admet-782	1	89	mullangi1	mullangi1	PROPN
admet-782	1	90	*	*	PROPN
admet-782	1	91	1	1	NUM
admet-782	1	92	drug	drug	NOUN
admet-782	1	93	metabolism	metabolism	NOUN
admet-782	1	94	and	and	CCONJ
admet-782	1	95	pharmacokinetics	pharmacokinetic	NOUN
admet-782	1	96	,	,	PUNCT
admet-782	1	97	jubilant	jubilant	PROPN
admet-782	1	98	biosys	biosys	PROPN
admet-782	1	99	ltd	ltd	PROPN
admet-782	1	100	,	,	PUNCT
admet-782	1	101	industrial	industrial	ADJ
admet-782	1	102	suburb	suburb	NOUN
admet-782	1	103	,	,	PUNCT
admet-782	1	104	yeshwanthpur	yeshwanthpur	PROPN
admet-782	1	105	,	,	PUNCT
admet-782	1	106	bangalore-560	bangalore-560	PROPN
admet-782	1	107	022	022	NUM
admet-782	1	108	,	,	PUNCT
admet-782	1	109	india	india	PROPN
admet-782	1	110	2	2	NUM
admet-782	1	111	department	department	NOUN
admet-782	1	112	of	of	ADP
admet-782	1	113	pharmacology	pharmacology	NOUN
admet-782	1	114	,	,	PUNCT
admet-782	1	115	raghavendra	raghavendra	PROPN
admet-782	1	116	institute	institute	PROPN
admet-782	1	117	of	of	ADP
admet-782	1	118	pharmaceutical	pharmaceutical	NOUN
admet-782	1	119	education	education	NOUN
admet-782	1	120	and	and	CCONJ
admet-782	1	121	research	research	NOUN
admet-782	1	122	,	,	PUNCT
admet-782	1	123	anantapur-515721	anantapur-515721	PROPN
admet-782	1	124	,	,	PUNCT
admet-782	1	125	a.p	a.p	PROPN
admet-782	1	126	,	,	PUNCT
admet-782	1	127	india	india	PROPN
admet-782	1	128	*	*	PUNCT
admet-782	1	129	corresponding	correspond	VERB
admet-782	1	130	author	author	NOUN
admet-782	1	131	:	:	PUNCT
admet-782	1	132	e	e	NOUN
admet-782	1	133	-	-	NOUN
admet-782	1	134	mail	mail	NOUN
admet-782	1	135	:	:	PUNCT
admet-782	1	136	mullangi.ramesh@jubilantinnovation.com	mullangi.ramesh@jubilantinnovation.com	X
admet-782	1	137	;	;	PUNCT
admet-782	1	138	tel	tel	PROPN
admet-782	1	139	.	.	PUNCT
admet-782	1	140	:	:	PUNCT
admet-782	2	1	+91	+91	NOUN
admet-782	2	2	-	-	PUNCT
admet-782	2	3	80	80	NUM
admet-782	2	4	-	-	PUNCT
admet-782	2	5	66628339	66628339	NUM
admet-782	2	6	received	receive	VERB
admet-782	2	7	:	:	PUNCT
admet-782	2	8	january	january	PROPN
admet-782	2	9	29	29	NUM
admet-782	2	10	,	,	PUNCT
admet-782	2	11	2020	2020	NUM
admet-782	2	12	;	;	PUNCT
admet-782	2	13	revised	revise	VERB
admet-782	2	14	:	:	PUNCT
admet-782	2	15	february	february	PROPN
admet-782	2	16	18	18	NUM
admet-782	2	17	,	,	PUNCT
admet-782	2	18	2020	2020	NUM
admet-782	2	19	;	;	PUNCT
admet-782	2	20	published	publish	VERB
admet-782	2	21	online	online	ADV
admet-782	2	22	:	:	PUNCT
admet-782	2	23	march	march	PROPN
admet-782	2	24	04	04	NUM
admet-782	2	25	,	,	PUNCT
admet-782	2	26	2020	2020	NUM
admet-782	2	27	abstract	abstract	ADJ
admet-782	2	28	copanlisib	copanlisib	PROPN
admet-782	2	29	is	be	AUX
admet-782	2	30	a	a	DET
admet-782	2	31	pan	pan	NOUN
admet-782	2	32	phosphatidylinositol	phosphatidylinositol	NOUN
admet-782	2	33	3	3	NUM
admet-782	2	34	-	-	PUNCT
admet-782	2	35	kinase	kinase	NOUN
admet-782	2	36	(	(	PUNCT
admet-782	2	37	pi3k	pi3k	PROPN
admet-782	2	38	)	)	PUNCT
admet-782	2	39	inhibitor	inhibitor	NOUN
admet-782	2	40	approved	approve	VERB
admet-782	2	41	for	for	ADP
admet-782	2	42	follicular	follicular	ADJ
admet-782	2	43	lymphoma	lymphoma	NOUN
admet-782	2	44	.	.	PUNCT
admet-782	3	1	in	in	ADP
admet-782	3	2	this	this	DET
admet-782	3	3	paper	paper	NOUN
admet-782	3	4	,	,	PUNCT
admet-782	3	5	we	we	PRON
admet-782	3	6	present	present	VERB
admet-782	3	7	the	the	DET
admet-782	3	8	data	datum	NOUN
admet-782	3	9	of	of	ADP
admet-782	3	10	development	development	NOUN
admet-782	3	11	and	and	CCONJ
admet-782	3	12	validation	validation	NOUN
admet-782	3	13	of	of	ADP
admet-782	3	14	a	a	DET
admet-782	3	15	high	high	ADJ
admet-782	3	16	-	-	PUNCT
admet-782	3	17	performance	performance	NOUN
admet-782	3	18	liquid	liquid	ADJ
admet-782	3	19	chromatography	chromatography	NOUN
admet-782	3	20	(	(	PUNCT
admet-782	3	21	hplc	hplc	NOUN
admet-782	3	22	)	)	PUNCT
admet-782	3	23	method	method	NOUN
admet-782	3	24	for	for	ADP
admet-782	3	25	the	the	DET
admet-782	3	26	quantitation	quantitation	NOUN
admet-782	3	27	of	of	ADP
admet-782	3	28	copanlisib	copanlisib	PROPN
admet-782	3	29	in	in	ADP
admet-782	3	30	mice	mice	NOUN
admet-782	3	31	plasma	plasma	NOUN
admet-782	3	32	as	as	ADP
admet-782	3	33	per	per	ADP
admet-782	3	34	the	the	DET
admet-782	3	35	fda	fda	PROPN
admet-782	3	36	regulatory	regulatory	PROPN
admet-782	3	37	guideline	guideline	NOUN
admet-782	3	38	.	.	PUNCT
admet-782	4	1	the	the	DET
admet-782	4	2	method	method	NOUN
admet-782	4	3	involves	involve	VERB
admet-782	4	4	the	the	DET
admet-782	4	5	extraction	extraction	NOUN
admet-782	4	6	of	of	ADP
admet-782	4	7	copanlisib	copanlisib	PROPN
admet-782	4	8	along	along	ADP
admet-782	4	9	with	with	ADP
admet-782	4	10	internal	internal	ADJ
admet-782	4	11	standard	standard	NOUN
admet-782	4	12	(	(	PUNCT
admet-782	4	13	is	be	AUX
admet-782	4	14	,	,	PUNCT
admet-782	4	15	enasidenib	enasidenib	NOUN
admet-782	4	16	)	)	PUNCT
admet-782	4	17	from	from	ADP
admet-782	4	18	mice	mice	NOUN
admet-782	4	19	plasma	plasma	NOUN
admet-782	4	20	(	(	PUNCT
admet-782	4	21	100	100	NUM
admet-782	4	22	µl	µl	NOUN
admet-782	4	23	)	)	PUNCT
admet-782	4	24	using	use	VERB
admet-782	4	25	ethyl	ethyl	PROPN
admet-782	4	26	acetate	acetate	NOUN
admet-782	4	27	as	as	ADP
admet-782	4	28	an	an	DET
admet-782	4	29	extraction	extraction	NOUN
admet-782	4	30	solvent	solvent	NOUN
admet-782	4	31	.	.	PUNCT
admet-782	5	1	the	the	DET
admet-782	5	2	chromatographic	chromatographic	ADJ
admet-782	5	3	resolution	resolution	NOUN
admet-782	5	4	of	of	ADP
admet-782	5	5	copanlisib	copanlisib	PROPN
admet-782	5	6	and	and	CCONJ
admet-782	5	7	the	the	PRON
admet-782	5	8	is	be	AUX
admet-782	5	9	was	be	AUX
admet-782	5	10	achieved	achieve	VERB
admet-782	5	11	on	on	ADP
admet-782	5	12	a	a	DET
admet-782	5	13	hypersil	hypersil	NOUN
admet-782	5	14	gold	gold	NOUN
admet-782	5	15	c18	c18	NOUN
admet-782	5	16	column	column	NOUN
admet-782	5	17	maintained	maintain	VERB
admet-782	5	18	at	at	ADP
admet-782	5	19	40	40	NUM
admet-782	5	20	°	°	ADP
admet-782	5	21	c	c	NOUN
admet-782	5	22	using	use	VERB
admet-782	5	23	a	a	DET
admet-782	5	24	binary	binary	ADJ
admet-782	5	25	gradient	gradient	NOUN
admet-782	5	26	mobile	mobile	ADJ
admet-782	5	27	phase	phase	NOUN
admet-782	5	28	[	[	PUNCT
admet-782	5	29	10	10	NUM
admet-782	5	30	mm	mm	NOUN
admet-782	5	31	ammonium	ammonium	NOUN
admet-782	5	32	formate	formate	NOUN
admet-782	5	33	(	(	PUNCT
admet-782	5	34	ph	ph	NOUN
admet-782	5	35	4.0	4.0	NUM
admet-782	5	36	)	)	PUNCT
admet-782	5	37	and	and	CCONJ
admet-782	5	38	acetonitrile	acetonitrile	NOUN
admet-782	5	39	]	]	X
admet-782	5	40	.	.	PUNCT
admet-782	6	1	the	the	DET
admet-782	6	2	flow	flow	NOUN
admet-782	6	3	-	-	PUNCT
admet-782	6	4	rate	rate	NOUN
admet-782	6	5	was	be	AUX
admet-782	6	6	0.8	0.8	NUM
admet-782	6	7	ml	ml	NOUN
admet-782	6	8	/	/	SYM
admet-782	6	9	min	min	NOUN
admet-782	6	10	.	.	PROPN
admet-782	6	11	for	for	ADP
admet-782	6	12	the	the	DET
admet-782	6	13	detection	detection	NOUN
admet-782	6	14	of	of	ADP
admet-782	6	15	copanlisib	copanlisib	PROPN
admet-782	6	16	and	and	CCONJ
admet-782	6	17	the	the	PRON
admet-782	6	18	is	be	AUX
admet-782	6	19	,	,	PUNCT
admet-782	6	20	the	the	DET
admet-782	6	21	photo	photo	NOUN
admet-782	6	22	-	-	PUNCT
admet-782	6	23	diode	diode	NOUN
admet-782	6	24	array	array	NOUN
admet-782	6	25	detector	detector	NOUN
admet-782	6	26	was	be	AUX
admet-782	6	27	set	set	VERB
admet-782	6	28	at	at	ADP
admet-782	6	29	λmax	λmax	NOUN
admet-782	6	30	310	310	NUM
admet-782	6	31	nm	nm	NOUN
admet-782	6	32	.	.	PUNCT
admet-782	7	1	copanlisib	copanlisib	PROPN
admet-782	8	1	and	and	CCONJ
admet-782	8	2	the	the	PRON
admet-782	8	3	is	be	AUX
admet-782	8	4	eluted	elute	VERB
admet-782	8	5	at	at	ADP
admet-782	8	6	6.60	6.60	NUM
admet-782	8	7	and	and	CCONJ
admet-782	8	8	7.80	7.80	NUM
admet-782	8	9	min	min	NOUN
admet-782	8	10	,	,	PUNCT
admet-782	8	11	respectively	respectively	ADV
admet-782	8	12	with	with	ADP
admet-782	8	13	a	a	DET
admet-782	8	14	total	total	ADJ
admet-782	8	15	run	run	NOUN
admet-782	8	16	time	time	NOUN
admet-782	8	17	of	of	ADP
admet-782	8	18	10	10	NUM
admet-782	8	19	min	min	NOUN
admet-782	8	20	.	.	PUNCT
admet-782	9	1	the	the	DET
admet-782	9	2	calibration	calibration	NOUN
admet-782	9	3	curve	curve	NOUN
admet-782	9	4	was	be	AUX
admet-782	9	5	linear	linear	ADJ
admet-782	9	6	over	over	ADP
admet-782	9	7	a	a	DET
admet-782	9	8	concentration	concentration	NOUN
admet-782	9	9	range	range	NOUN
admet-782	9	10	of	of	ADP
admet-782	9	11	50	50	NUM
admet-782	9	12	to	to	PART
admet-782	9	13	5000	5000	NUM
admet-782	9	14	ng	ng	NOUN
admet-782	9	15	/	/	SYM
admet-782	9	16	ml	ml	X
admet-782	9	17	for	for	ADP
admet-782	9	18	copanlisib	copanlisib	PROPN
admet-782	9	19	(	(	PUNCT
admet-782	9	20	r	r	NOUN
admet-782	9	21	2	2	NUM
admet-782	9	22			NUM
admet-782	9	23	0.998	0.998	NUM
admet-782	9	24	)	)	PUNCT
admet-782	9	25	.	.	PUNCT
admet-782	10	1	the	the	DET
admet-782	10	2	results	result	NOUN
admet-782	10	3	of	of	ADP
admet-782	10	4	intraand	intraand	NOUN
admet-782	10	5	inter	inter	ADJ
admet-782	10	6	-	-	ADJ
admet-782	10	7	day	day	NOUN
admet-782	10	8	accuracy	accuracy	NOUN
admet-782	10	9	and	and	CCONJ
admet-782	10	10	precision	precision	NOUN
admet-782	10	11	studies	study	NOUN
admet-782	10	12	were	be	AUX
admet-782	10	13	within	within	ADP
admet-782	10	14	the	the	DET
admet-782	10	15	acceptable	acceptable	ADJ
admet-782	10	16	limits	limit	NOUN
admet-782	10	17	.	.	PUNCT
admet-782	11	1	copanlisib	copanlisib	PROPN
admet-782	11	2	was	be	AUX
admet-782	11	3	stable	stable	ADJ
admet-782	11	4	on	on	ADP
admet-782	11	5	bench	bench	NOUN
admet-782	11	6	-	-	PUNCT
admet-782	11	7	top	top	NOUN
admet-782	11	8	,	,	PUNCT
admet-782	11	9	in	in	ADP
admet-782	11	10	auto	auto	NOUN
admet-782	11	11	-	-	PUNCT
admet-782	11	12	sampler	sampler	NOUN
admet-782	11	13	,	,	PUNCT
admet-782	11	14	up	up	ADP
admet-782	11	15	to	to	PART
admet-782	11	16	three	three	NUM
admet-782	11	17	freeze	freeze	VERB
admet-782	11	18	/	/	SYM
admet-782	11	19	thaw	thaw	NOUN
admet-782	11	20	cycle	cycle	NOUN
admet-782	11	21	and	and	CCONJ
admet-782	11	22	long	long	ADJ
admet-782	11	23	-	-	PUNCT
admet-782	11	24	term	term	NOUN
admet-782	11	25	storage	storage	NOUN
admet-782	11	26	at	at	ADP
admet-782	11	27	-80	-80	NOUN
admet-782	11	28	°	°	PROPN
admet-782	11	29	c	c	NOUN
admet-782	11	30	.	.	PUNCT
admet-782	12	1	the	the	DET
admet-782	12	2	application	application	NOUN
admet-782	12	3	of	of	ADP
admet-782	12	4	the	the	DET
admet-782	12	5	validated	validate	VERB
admet-782	12	6	method	method	NOUN
admet-782	12	7	was	be	AUX
admet-782	12	8	shown	show	VERB
admet-782	12	9	in	in	ADP
admet-782	12	10	a	a	DET
admet-782	12	11	mice	mice	NOUN
admet-782	12	12	pharmacokinetic	pharmacokinetic	ADJ
admet-782	12	13	study	study	NOUN
admet-782	12	14	.	.	PUNCT
admet-782	13	1	©	©	PROPN
admet-782	13	2	2020	2020	NUM
admet-782	13	3	by	by	ADP
admet-782	13	4	the	the	DET
admet-782	13	5	authors	author	NOUN
admet-782	13	6	.	.	PUNCT
admet-782	14	1	this	this	DET
admet-782	14	2	article	article	NOUN
admet-782	14	3	is	be	AUX
admet-782	14	4	an	an	DET
admet-782	14	5	open	open	ADJ
admet-782	14	6	-	-	PUNCT
admet-782	14	7	access	access	NOUN
admet-782	14	8	article	article	NOUN
admet-782	14	9	distributed	distribute	VERB
admet-782	14	10	under	under	ADP
admet-782	14	11	the	the	DET
admet-782	14	12	terms	term	NOUN
admet-782	14	13	and	and	CCONJ
admet-782	14	14	conditions	condition	NOUN
admet-782	14	15	of	of	ADP
admet-782	14	16	the	the	DET
admet-782	14	17	creative	creative	ADJ
admet-782	14	18	commons	common	NOUN
admet-782	14	19	attribution	attribution	NOUN
admet-782	14	20	license	license	NOUN
admet-782	14	21	(	(	PUNCT
admet-782	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-782	14	23	)	)	PUNCT
admet-782	14	24	.	.	PUNCT
admet-782	15	1	keywords	keyword	NOUN
admet-782	15	2	copanlisib	copanlisib	PROPN
admet-782	15	3	;	;	PUNCT
admet-782	15	4	hplc	hplc	NOUN
admet-782	15	5	;	;	PUNCT
admet-782	15	6	method	method	NOUN
admet-782	15	7	validation	validation	NOUN
admet-782	15	8	;	;	PUNCT
admet-782	15	9	mice	mice	NOUN
admet-782	15	10	plasma	plasma	NOUN
admet-782	15	11	;	;	PUNCT
admet-782	15	12	pharmacokinetics	pharmacokinetic	NOUN
admet-782	15	13	introduction	introduction	NOUN
admet-782	15	14	phosphoinositide	phosphoinositide	NOUN
admet-782	15	15	3	3	NUM
admet-782	15	16	-	-	PUNCT
admet-782	15	17	kinases	kinase	NOUN
admet-782	15	18	(	(	PUNCT
admet-782	15	19	pi3ks	pi3k	VERB
admet-782	15	20	)	)	PUNCT
admet-782	15	21	are	be	AUX
admet-782	15	22	lipid	lipid	ADJ
admet-782	15	23	kinases	kinase	NOUN
admet-782	15	24	,	,	PUNCT
admet-782	15	25	which	which	PRON
admet-782	15	26	play	play	VERB
admet-782	15	27	a	a	DET
admet-782	15	28	pivotal	pivotal	ADJ
admet-782	15	29	role	role	NOUN
admet-782	15	30	in	in	ADP
admet-782	15	31	cell	cell	NOUN
admet-782	15	32	cycle	cycle	NOUN
admet-782	15	33	,	,	PUNCT
admet-782	15	34	cellular	cellular	ADJ
admet-782	15	35	metabolism	metabolism	NOUN
admet-782	15	36	,	,	PUNCT
admet-782	15	37	apoptosis	apoptosis	NOUN
admet-782	15	38	etc	etc	X
admet-782	15	39	.	.	X
admet-782	15	40	along	along	ADP
admet-782	15	41	with	with	ADP
admet-782	15	42	α	α	NOUN
admet-782	15	43	-	-	PUNCT
admet-782	15	44	serine	serine	ADJ
admet-782	15	45	/	/	SYM
admet-782	15	46	threonine	threonine	ADJ
admet-782	15	47	-	-	PUNCT
admet-782	15	48	protein	protein	NOUN
admet-782	15	49	kinase	kinase	NOUN
admet-782	15	50	(	(	PUNCT
admet-782	15	51	akt)/mammalian	akt)/mammalian	ADJ
admet-782	15	52	target	target	NOUN
admet-782	15	53	of	of	ADP
admet-782	15	54	rapamycin	rapamycin	NOUN
admet-782	15	55	(	(	PUNCT
admet-782	15	56	mtor	mtor	NOUN
admet-782	15	57	)	)	PUNCT
admet-782	15	58	pathway	pathway	NOUN
admet-782	16	1	[	[	X
admet-782	16	2	1	1	NUM
admet-782	16	3	]	]	PUNCT
admet-782	16	4	.	.	PUNCT
admet-782	17	1	abnormal	abnormal	ADJ
admet-782	17	2	activation	activation	NOUN
admet-782	17	3	of	of	ADP
admet-782	17	4	pi3k	pi3k	NOUN
admet-782	17	5	pathway	pathway	NOUN
admet-782	17	6	has	have	AUX
admet-782	17	7	been	be	AUX
admet-782	17	8	shown	show	VERB
admet-782	17	9	to	to	PART
admet-782	17	10	drive	drive	VERB
admet-782	17	11	tumorigenesis	tumorigenesis	NOUN
admet-782	17	12	[	[	X
admet-782	17	13	2	2	NUM
admet-782	17	14	]	]	PUNCT
admet-782	17	15	.	.	PUNCT
admet-782	18	1	among	among	ADP
admet-782	18	2	three	three	NUM
admet-782	18	3	classes	class	NOUN
admet-782	18	4	of	of	ADP
admet-782	18	5	the	the	DET
admet-782	18	6	pi3k	pi3k	NOUN
admet-782	18	7	enzyme	enzyme	NOUN
admet-782	18	8	,	,	PUNCT
admet-782	18	9	class	class	NOUN
admet-782	18	10	i	i	PRON
admet-782	18	11	pi3k	pi3k	PROPN
admet-782	18	12	is	be	AUX
admet-782	18	13	linked	link	VERB
admet-782	18	14	with	with	ADP
admet-782	18	15	malignance	malignance	NOUN
admet-782	18	16	and	and	CCONJ
admet-782	18	17	it	it	PRON
admet-782	18	18	exists	exist	VERB
admet-782	18	19	in	in	ADP
admet-782	18	20	four	four	NUM
admet-782	18	21	isoforms	isoform	NOUN
admet-782	18	22	:	:	PUNCT
admet-782	18	23	α	α	X
admet-782	18	24	,	,	PUNCT
admet-782	18	25	β	β	X
admet-782	18	26	,	,	PUNCT
admet-782	18	27	γ	γ	X
admet-782	18	28	and	and	CCONJ
admet-782	18	29	δ	δ	PROPN
admet-782	19	1	[	[	X
admet-782	19	2	3,4	3,4	NUM
admet-782	19	3	]	]	PUNCT
admet-782	19	4	.	.	PUNCT
admet-782	20	1	pi3k	pi3k	NOUN
admet-782	20	2	inhibitors	inhibitor	NOUN
admet-782	20	3	represent	represent	VERB
admet-782	20	4	a	a	DET
admet-782	20	5	novel	novel	ADJ
admet-782	20	6	class	class	NOUN
admet-782	20	7	of	of	ADP
admet-782	20	8	targeted	target	VERB
admet-782	20	9	therapies	therapy	NOUN
admet-782	20	10	for	for	ADP
admet-782	20	11	the	the	DET
admet-782	20	12	treatment	treatment	NOUN
admet-782	20	13	of	of	ADP
admet-782	20	14	human	human	ADJ
admet-782	20	15	malignancies	malignancy	NOUN
admet-782	20	16	[	[	X
admet-782	20	17	5	5	NUM
admet-782	20	18	]	]	PUNCT
admet-782	20	19	.	.	PUNCT
admet-782	21	1	preclinical	preclinical	ADJ
admet-782	21	2	and	and	CCONJ
admet-782	21	3	clinical	clinical	ADJ
admet-782	21	4	studies	study	NOUN
admet-782	21	5	demonstrated	demonstrate	VERB
admet-782	21	6	that	that	SCONJ
admet-782	21	7	inhibition	inhibition	NOUN
admet-782	21	8	of	of	ADP
admet-782	21	9	pi3k	pi3k	NOUN
admet-782	21	10	is	be	AUX
admet-782	21	11	an	an	DET
admet-782	21	12	effective	effective	ADJ
admet-782	21	13	therapeutic	therapeutic	ADJ
admet-782	21	14	strategy	strategy	NOUN
admet-782	21	15	for	for	ADP
admet-782	21	16	lymphomas	lymphoma	NOUN
admet-782	21	17	treatment	treatment	NOUN
admet-782	21	18	[	[	X
admet-782	21	19	6	6	NUM
admet-782	21	20	]	]	PUNCT
admet-782	21	21	.	.	PUNCT
admet-782	22	1	copanlisib	copanlisib	PROPN
admet-782	22	2	(	(	PUNCT
admet-782	22	3	fig	fig	NOUN
admet-782	22	4	.	.	PUNCT
admet-782	23	1	1	1	NUM
admet-782	23	2	;	;	PUNCT
admet-782	23	3	bay	bay	NOUN
admet-782	23	4	80	80	NUM
admet-782	23	5	-	-	PUNCT
admet-782	23	6	6946	6946	NUM
admet-782	23	7	)	)	PUNCT
admet-782	23	8	,	,	PUNCT
admet-782	23	9	is	be	AUX
admet-782	23	10	a	a	DET
admet-782	23	11	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	23	12	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	23	13	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-782	23	14	mailto:mullangi.ramesh@jubilantinnovation.com	mailto:mullangi.ramesh@jubilantinnovation.com	PROPN
admet-782	24	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-782	24	2	r.	r.	PROPN
admet-782	24	3	mullangi	mullangi	VERB
admet-782	24	4	et	et	PROPN
admet-782	24	5	al	al	PROPN
admet-782	24	6	.	.	PROPN
admet-782	24	7	admet	admet	PROPN
admet-782	24	8	&	&	CCONJ
admet-782	24	9	dmpk	dmpk	PROPN
admet-782	24	10	8(1	8(1	NOUN
admet-782	24	11	)	)	PUNCT
admet-782	24	12	(	(	PUNCT
admet-782	24	13	2020	2020	NUM
admet-782	24	14	)	)	PUNCT
admet-782	24	15	113	113	NUM
admet-782	24	16	-	-	SYM
admet-782	24	17	121	121	NUM
admet-782	24	18	114	114	NUM
admet-782	24	19	pan	pan	NOUN
admet-782	24	20	-	-	ADJ
admet-782	24	21	pi3k	pi3k	ADJ
admet-782	24	22	inhibitor	inhibitor	NOUN
admet-782	24	23	with	with	ADP
admet-782	24	24	predominant	predominant	ADJ
admet-782	24	25	activity	activity	NOUN
admet-782	24	26	against	against	ADP
admet-782	24	27	pi3k	pi3k	PROPN
admet-782	24	28	-	-	PUNCT
admet-782	24	29	α	α	NOUN
admet-782	24	30	and	and	CCONJ
admet-782	24	31	pi3k	pi3k	PROPN
admet-782	24	32	-	-	PUNCT
admet-782	24	33	δ	δ	NOUN
admet-782	24	34	forms	form	NOUN
admet-782	24	35	,	,	PUNCT
admet-782	24	36	which	which	PRON
admet-782	24	37	are	be	AUX
admet-782	24	38	expressed	express	VERB
admet-782	24	39	in	in	ADP
admet-782	24	40	malignant	malignant	ADJ
admet-782	24	41	b	b	NOUN
admet-782	24	42	-	-	PUNCT
admet-782	24	43	cells	cell	NOUN
admet-782	24	44	.	.	PUNCT
admet-782	25	1	the	the	DET
admet-782	25	2	ic50	ic50	PROPN
admet-782	25	3	(	(	PUNCT
admet-782	25	4	half	half	ADV
admet-782	25	5	-	-	PUNCT
admet-782	25	6	maximal	maximal	ADJ
admet-782	25	7	inhibitory	inhibitory	ADJ
admet-782	25	8	concentration	concentration	NOUN
admet-782	25	9	)	)	PUNCT
admet-782	25	10	against	against	ADP
admet-782	25	11	pi3k	pi3k	PROPN
admet-782	25	12	α	α	PROPN
admet-782	25	13	,	,	PUNCT
admet-782	25	14	β	β	X
admet-782	25	15	,	,	PUNCT
admet-782	25	16	γ	γ	PROPN
admet-782	25	17	and	and	CCONJ
admet-782	25	18	δ	δ	PROPN
admet-782	25	19	isoforms	isoform	NOUN
admet-782	25	20	was	be	AUX
admet-782	25	21	0.5	0.5	NUM
admet-782	25	22	,	,	PUNCT
admet-782	25	23	3.7	3.7	NUM
admet-782	25	24	,	,	PUNCT
admet-782	25	25	6.4	6.4	NUM
admet-782	25	26	and	and	CCONJ
admet-782	25	27	0.7	0.7	NUM
admet-782	25	28	nmol	nmol	NOUN
admet-782	25	29	/	/	SYM
admet-782	25	30	l	l	NOUN
admet-782	25	31	,	,	PUNCT
admet-782	25	32	respectively	respectively	ADV
admet-782	25	33	[	[	X
admet-782	25	34	7	7	NUM
admet-782	25	35	]	]	PUNCT
admet-782	25	36	.	.	PUNCT
admet-782	26	1	it	it	PRON
admet-782	26	2	induces	induce	VERB
admet-782	26	3	tumor	tumor	NOUN
admet-782	26	4	cell	cell	NOUN
admet-782	26	5	death	death	NOUN
admet-782	26	6	by	by	ADP
admet-782	26	7	apoptosis	apoptosis	NOUN
admet-782	26	8	and	and	CCONJ
admet-782	26	9	inhibition	inhibition	NOUN
admet-782	26	10	of	of	ADP
admet-782	26	11	proliferation	proliferation	NOUN
admet-782	26	12	of	of	ADP
admet-782	26	13	primary	primary	ADJ
admet-782	26	14	malignant	malignant	NOUN
admet-782	26	15	b	b	NOUN
admet-782	26	16	cell	cell	NOUN
admet-782	26	17	lines	line	NOUN
admet-782	26	18	.	.	PUNCT
admet-782	27	1	copanlisib	copanlisib	PROPN
admet-782	27	2	was	be	AUX
admet-782	27	3	approved	approve	VERB
admet-782	27	4	for	for	ADP
admet-782	27	5	treatment	treatment	NOUN
admet-782	27	6	of	of	ADP
admet-782	27	7	follicular	follicular	ADJ
admet-782	27	8	lymphoma	lymphoma	NOUN
admet-782	27	9	as	as	ADP
admet-782	27	10	an	an	DET
admet-782	27	11	intravenous	intravenous	ADJ
admet-782	27	12	infusion	infusion	NOUN
admet-782	27	13	for	for	ADP
admet-782	27	14	adults	adult	NOUN
admet-782	27	15	.	.	PUNCT
admet-782	28	1	in	in	ADP
admet-782	28	2	clinic	clinic	NOUN
admet-782	28	3	,	,	PUNCT
admet-782	28	4	at	at	ADP
admet-782	28	5	0.8	0.8	NUM
admet-782	28	6	mg	mg	PROPN
admet-782	28	7	/	/	SYM
admet-782	28	8	kg	kg	PROPN
admet-782	28	9	(	(	PUNCT
admet-782	28	10	intravenous	intravenous	ADJ
admet-782	28	11	infusion	infusion	NOUN
admet-782	28	12	)	)	PUNCT
admet-782	28	13	,	,	PUNCT
admet-782	28	14	copanlisib	copanlisib	PROPN
admet-782	28	15	showed	show	VERB
admet-782	28	16	promising	promising	ADJ
admet-782	28	17	efficacy	efficacy	NOUN
admet-782	28	18	in	in	ADP
admet-782	28	19	patients	patient	NOUN
admet-782	28	20	with	with	ADP
admet-782	28	21	solid	solid	ADJ
admet-782	28	22	tumors	tumor	NOUN
admet-782	28	23	and	and	CCONJ
admet-782	28	24	hematological	hematological	ADJ
admet-782	28	25	malignancies	malignancy	NOUN
admet-782	28	26	.	.	PUNCT
admet-782	29	1	across	across	ADP
admet-782	29	2	the	the	DET
admet-782	29	3	dose	dose	ADJ
admet-782	29	4	range	range	NOUN
admet-782	29	5	of	of	ADP
admet-782	29	6	0.1	0.1	NUM
admet-782	29	7	-	-	SYM
admet-782	29	8	1.2	1.2	NUM
admet-782	29	9	mg	mg	PROPN
admet-782	29	10	/	/	SYM
admet-782	29	11	kg	kg	PROPN
admet-782	29	12	,	,	PUNCT
admet-782	29	13	it	it	PRON
admet-782	29	14	has	have	AUX
admet-782	29	15	shown	show	VERB
admet-782	29	16	dose	dose	VERB
admet-782	29	17	proportional	proportional	ADJ
admet-782	29	18	increase	increase	NOUN
admet-782	29	19	in	in	ADP
admet-782	29	20	cmax	cmax	NOUN
admet-782	29	21	(	(	PUNCT
admet-782	29	22	maximum	maximum	ADJ
admet-782	29	23	concentration	concentration	NOUN
admet-782	29	24	in	in	ADP
admet-782	29	25	plasma	plasma	NOUN
admet-782	29	26	)	)	PUNCT
admet-782	29	27	and	and	CCONJ
admet-782	29	28	auc0	auc0	PROPN
admet-782	29	29	-	-	PUNCT
admet-782	29	30	t	t	PROPN
admet-782	29	31	(	(	PUNCT
admet-782	29	32	area	area	NOUN
admet-782	29	33	under	under	ADP
admet-782	29	34	curve	curve	NOUN
admet-782	29	35	from	from	ADP
admet-782	29	36	time	time	NOUN
admet-782	29	37	zero	zero	NUM
admet-782	29	38	to	to	ADP
admet-782	29	39	last	last	ADJ
admet-782	29	40	measurable	measurable	ADJ
admet-782	29	41	time	time	NOUN
admet-782	29	42	point	point	NOUN
admet-782	29	43	)	)	PUNCT
admet-782	29	44	.	.	PUNCT
admet-782	30	1	typically	typically	ADV
admet-782	30	2	,	,	PUNCT
admet-782	30	3	cmax	cmax	NOUN
admet-782	30	4	attained	attain	VERB
admet-782	30	5	between	between	ADP
admet-782	30	6	0.5	0.5	NUM
admet-782	30	7	-	-	SYM
admet-782	30	8	1.0	1.0	NUM
admet-782	30	9	h	h	NOUN
admet-782	30	10	(	(	PUNCT
admet-782	30	11	tmax	tmax	ADV
admet-782	30	12	)	)	PUNCT
admet-782	30	13	.	.	PUNCT
admet-782	31	1	the	the	DET
admet-782	31	2	human	human	ADJ
admet-782	31	3	plasma	plasma	NOUN
admet-782	31	4	protein	protein	NOUN
admet-782	31	5	binding	bind	VERB
admet-782	31	6	of	of	ADP
admet-782	31	7	copanlisib	copanlisib	PROPN
admet-782	31	8	is	be	AUX
admet-782	31	9	~84	~84	NUM
admet-782	32	1	%	%	NOUN
admet-782	32	2	.	.	PUNCT
admet-782	33	1	copanlisib	copanlisib	PROPN
admet-782	33	2	was	be	AUX
admet-782	33	3	majorly	majorly	ADV
admet-782	33	4	metabolized	metabolize	VERB
admet-782	33	5	by	by	ADP
admet-782	33	6	cyp3a4	cyp3a4	PROPN
admet-782	33	7	(	(	PUNCT
admet-782	33	8	>	>	SYM
admet-782	33	9	90	90	NUM
admet-782	33	10	%	%	NOUN
admet-782	33	11	metabolism	metabolism	NOUN
admet-782	33	12	)	)	PUNCT
admet-782	33	13	and	and	CCONJ
admet-782	33	14	to	to	ADP
admet-782	33	15	some	some	DET
admet-782	33	16	extent	extent	NOUN
admet-782	33	17	by	by	ADP
admet-782	33	18	cyp1a1	cyp1a1	PROPN
admet-782	33	19	(	(	PUNCT
admet-782	33	20	~10	~10	PUNCT
admet-782	33	21	%	%	NOUN
admet-782	33	22	of	of	ADP
admet-782	33	23	metabolism	metabolism	NOUN
admet-782	33	24	)	)	PUNCT
admet-782	33	25	to	to	PART
admet-782	33	26	yield	yield	VERB
admet-782	33	27	m1	m1	NOUN
admet-782	33	28	,	,	PUNCT
admet-782	33	29	an	an	DET
admet-782	33	30	active	active	ADJ
admet-782	33	31	metabolite	metabolite	NOUN
admet-782	33	32	,	,	PUNCT
admet-782	33	33	which	which	PRON
admet-782	33	34	possess	possess	VERB
admet-782	33	35	similar	similar	ADJ
admet-782	33	36	potency	potency	NOUN
admet-782	33	37	as	as	ADP
admet-782	33	38	copanlisib	copanlisib	PROPN
admet-782	33	39	.	.	PUNCT
admet-782	34	1	the	the	DET
admet-782	34	2	terminal	terminal	ADJ
admet-782	34	3	half	half	ADJ
admet-782	34	4	-	-	PUNCT
admet-782	34	5	life	life	NOUN
admet-782	34	6	and	and	CCONJ
admet-782	34	7	clearance	clearance	NOUN
admet-782	34	8	for	for	ADP
admet-782	34	9	copanlisib	copanlisib	PROPN
admet-782	34	10	at	at	ADP
admet-782	34	11	0.8	0.8	NUM
admet-782	34	12	mg	mg	NOUN
admet-782	34	13	/	/	SYM
admet-782	34	14	kg	kg	PROPN
admet-782	34	15	were	be	AUX
admet-782	34	16	39.1	39.1	NUM
admet-782	34	17	h	h	NOUN
admet-782	34	18	and	and	CCONJ
admet-782	34	19	18.9	18.9	NUM
admet-782	34	20	l	l	NOUN
admet-782	34	21	/	/	SYM
admet-782	34	22	h.	h.	PROPN
admet-782	34	23	copanlisib	copanlisib	PROPN
admet-782	34	24	has	have	VERB
admet-782	34	25	high	high	ADJ
admet-782	34	26	volume	volume	NOUN
admet-782	34	27	of	of	ADP
admet-782	34	28	distribution	distribution	NOUN
admet-782	34	29	(	(	PUNCT
admet-782	34	30	871	871	NUM
admet-782	34	31	l	l	NOUN
admet-782	34	32	)	)	PUNCT
admet-782	34	33	.	.	PUNCT
admet-782	35	1	up	up	ADP
admet-782	35	2	to	to	PART
admet-782	35	3	50	50	NUM
admet-782	35	4	%	%	NOUN
admet-782	35	5	of	of	ADP
admet-782	35	6	unchanged	unchanged	ADJ
admet-782	35	7	drug	drug	NOUN
admet-782	35	8	and	and	CCONJ
admet-782	35	9	remaining	remain	VERB
admet-782	35	10	amount	amount	NOUN
admet-782	35	11	in	in	ADP
admet-782	35	12	the	the	DET
admet-782	35	13	form	form	NOUN
admet-782	35	14	of	of	ADP
admet-782	35	15	metabolites	metabolite	NOUN
admet-782	35	16	is	be	AUX
admet-782	35	17	excreted	excrete	VERB
admet-782	35	18	in	in	ADP
admet-782	35	19	humans	human	NOUN
admet-782	35	20	[	[	X
admet-782	35	21	8	8	NUM
admet-782	35	22	]	]	PUNCT
admet-782	35	23	.	.	PUNCT
admet-782	36	1	figure	figure	NOUN
admet-782	36	2	1	1	NUM
admet-782	36	3	.	.	PUNCT
admet-782	36	4	structural	structural	ADJ
admet-782	36	5	representation	representation	NOUN
admet-782	36	6	of	of	ADP
admet-782	36	7	copanlisib	copanlisib	PROPN
admet-782	36	8	and	and	CCONJ
admet-782	36	9	enasidenib	enasidenib	NOUN
admet-782	36	10	(	(	PUNCT
admet-782	36	11	internal	internal	ADJ
admet-782	36	12	standard	standard	NOUN
admet-782	36	13	,	,	PUNCT
admet-782	36	14	is	be	AUX
admet-782	36	15	)	)	PUNCT
admet-782	36	16	until	until	ADP
admet-782	36	17	date	date	NOUN
admet-782	36	18	,	,	PUNCT
admet-782	36	19	only	only	ADV
admet-782	36	20	one	one	NUM
admet-782	36	21	bioanalytical	bioanalytical	ADJ
admet-782	36	22	method	method	NOUN
admet-782	36	23	was	be	AUX
admet-782	36	24	published	publish	VERB
admet-782	36	25	for	for	ADP
admet-782	36	26	quantification	quantification	NOUN
admet-782	36	27	of	of	ADP
admet-782	36	28	copanlisib	copanlisib	PROPN
admet-782	37	1	[	[	X
admet-782	37	2	9	9	NUM
admet-782	37	3	]	]	PUNCT
admet-782	37	4	.	.	PUNCT
admet-782	38	1	in	in	ADP
admet-782	38	2	the	the	DET
admet-782	38	3	reported	report	VERB
admet-782	38	4	lc	lc	PROPN
admet-782	38	5	-	-	PUNCT
admet-782	38	6	ms	ms	PROPN
admet-782	38	7	/	/	SYM
admet-782	38	8	ms	ms	NOUN
admet-782	38	9	(	(	PUNCT
admet-782	38	10	liquid	liquid	ADJ
admet-782	38	11	chromatography	chromatography	NOUN
admet-782	38	12	coupled	couple	VERB
admet-782	38	13	with	with	ADP
admet-782	38	14	tandem	tandem	PROPN
admet-782	38	15	mass	mass	PROPN
admet-782	38	16	spectrometry	spectrometry	NOUN
admet-782	38	17	)	)	PUNCT
admet-782	38	18	method	method	NOUN
admet-782	38	19	,	,	PUNCT
admet-782	38	20	authors	author	NOUN
admet-782	38	21	used	use	VERB
admet-782	38	22	one	one	NUM
admet-782	38	23	step	step	NOUN
admet-782	38	24	liquid	liquid	NOUN
admet-782	38	25	-	-	PUNCT
admet-782	38	26	liquid	liquid	NOUN
admet-782	38	27	extraction	extraction	NOUN
admet-782	38	28	method	method	NOUN
admet-782	38	29	for	for	ADP
admet-782	38	30	mice	mice	NOUN
admet-782	38	31	plasma	plasma	NOUN
admet-782	38	32	samples	sample	NOUN
admet-782	38	33	processing	processing	NOUN
admet-782	38	34	.	.	PUNCT
admet-782	39	1	the	the	DET
admet-782	39	2	linearity	linearity	NOUN
admet-782	39	3	range	range	NOUN
admet-782	39	4	was	be	AUX
admet-782	39	5	3.59	3.59	NUM
admet-782	39	6	-	-	SYM
admet-782	39	7	3588	3588	NUM
admet-782	39	8	ng	ng	PROPN
admet-782	39	9	/	/	SYM
admet-782	39	10	ml	ml	PROPN
admet-782	39	11	.	.	PUNCT
admet-782	40	1	using	use	VERB
admet-782	40	2	an	an	DET
admet-782	40	3	isocratic	isocratic	ADJ
admet-782	40	4	mobile	mobile	ADJ
admet-782	40	5	phase	phase	NOUN
admet-782	40	6	,	,	PUNCT
admet-782	40	7	copanlisib	copanlisib	PROPN
admet-782	40	8	and	and	CCONJ
admet-782	40	9	the	the	DET
admet-782	40	10	internal	internal	ADJ
admet-782	40	11	standard	standard	NOUN
admet-782	40	12	were	be	AUX
admet-782	40	13	resolved	resolve	VERB
admet-782	40	14	on	on	ADP
admet-782	40	15	a	a	DET
admet-782	40	16	hypurity	hypurity	NOUN
admet-782	40	17	c18	c18	NOUN
admet-782	40	18	column	column	NOUN
admet-782	40	19	having	have	VERB
admet-782	40	20	a	a	DET
admet-782	40	21	total	total	ADJ
admet-782	40	22	run	run	NOUN
admet-782	40	23	time	time	NOUN
admet-782	40	24	of	of	ADP
admet-782	40	25	3.0	3.0	NUM
admet-782	40	26	min	min	NOUN
admet-782	40	27	.	.	PUNCT
admet-782	41	1	although	although	SCONJ
admet-782	41	2	lc	lc	PROPN
admet-782	41	3	-	-	PUNCT
admet-782	41	4	ms	ms	NOUN
admet-782	41	5	/	/	SYM
admet-782	41	6	ms	ms	PROPN
admet-782	41	7	is	be	AUX
admet-782	41	8	a	a	DET
admet-782	41	9	powerful	powerful	ADJ
admet-782	41	10	tool	tool	NOUN
admet-782	41	11	for	for	ADP
admet-782	41	12	the	the	DET
admet-782	41	13	quantitation	quantitation	NOUN
admet-782	41	14	of	of	ADP
admet-782	41	15	drugs	drug	NOUN
admet-782	41	16	in	in	ADP
admet-782	41	17	various	various	ADJ
admet-782	41	18	biological	biological	ADJ
admet-782	41	19	matrices	matrix	NOUN
admet-782	41	20	with	with	ADP
admet-782	41	21	higher	high	ADJ
admet-782	41	22	sensitivity	sensitivity	NOUN
admet-782	41	23	in	in	ADP
admet-782	41	24	short	short	ADJ
admet-782	41	25	run	run	NOUN
admet-782	41	26	time	time	NOUN
admet-782	41	27	,	,	PUNCT
admet-782	41	28	its	its	PRON
admet-782	41	29	high	high	ADJ
admet-782	41	30	cost	cost	NOUN
admet-782	41	31	and	and	CCONJ
admet-782	41	32	maintenance	maintenance	NOUN
admet-782	41	33	limit	limit	VERB
admet-782	41	34	its	its	PRON
admet-782	41	35	availability	availability	NOUN
admet-782	41	36	for	for	ADP
admet-782	41	37	most	most	ADJ
admet-782	41	38	of	of	ADP
admet-782	41	39	the	the	DET
admet-782	41	40	hospitals	hospital	NOUN
admet-782	41	41	,	,	PUNCT
admet-782	41	42	academic	academic	ADJ
admet-782	41	43	institutes	institute	NOUN
admet-782	41	44	and	and	CCONJ
admet-782	41	45	research	research	NOUN
admet-782	41	46	laboratories	laboratory	NOUN
admet-782	41	47	.	.	PUNCT
admet-782	42	1	the	the	DET
admet-782	42	2	lower	low	ADJ
admet-782	42	3	cost	cost	NOUN
admet-782	42	4	and	and	CCONJ
admet-782	42	5	affordability	affordability	NOUN
admet-782	42	6	of	of	ADP
admet-782	42	7	the	the	DET
admet-782	42	8	hplc	hplc	NOUN
admet-782	42	9	instrument	instrument	NOUN
admet-782	42	10	compared	compare	VERB
admet-782	42	11	to	to	ADP
admet-782	42	12	that	that	PRON
admet-782	42	13	of	of	ADP
admet-782	42	14	lc	lc	PROPN
admet-782	42	15	-	-	PUNCT
admet-782	42	16	ms	ms	PROPN
admet-782	42	17	/	/	SYM
admet-782	42	18	ms	ms	PROPN
admet-782	42	19	renders	render	VERB
admet-782	42	20	hplc	hplc	NOUN
admet-782	42	21	methods	method	NOUN
admet-782	42	22	more	more	ADV
admet-782	42	23	eligible	eligible	ADJ
admet-782	42	24	for	for	ADP
admet-782	42	25	wide	wide	ADJ
admet-782	42	26	routine	routine	ADJ
admet-782	42	27	use	use	NOUN
admet-782	42	28	.	.	PUNCT
admet-782	43	1	in	in	ADP
admet-782	43	2	clinic	clinic	NOUN
admet-782	43	3	,	,	PUNCT
admet-782	43	4	at	at	ADP
admet-782	43	5	efficacy	efficacy	NOUN
admet-782	43	6	dose	dose	NOUN
admet-782	43	7	of	of	ADP
admet-782	43	8	0.8	0.8	NUM
admet-782	43	9	mg	mg	PROPN
admet-782	43	10	/	/	SYM
admet-782	43	11	kg	kg	PROPN
admet-782	43	12	,	,	PUNCT
admet-782	43	13	copanlisib	copanlisib	PROPN
admet-782	43	14	plasma	plasma	NOUN
admet-782	43	15	concentrations	concentration	NOUN
admet-782	43	16	were	be	AUX
admet-782	43	17	~50	~50	X
admet-782	43	18	ng	ng	PROPN
admet-782	43	19	/	/	SYM
admet-782	43	20	ml	ml	X
admet-782	43	21	at	at	ADP
admet-782	43	22	8	8	NUM
admet-782	43	23	h	h	NOUN
admet-782	43	24	(	(	PUNCT
admet-782	43	25	both	both	CCONJ
admet-782	43	26	on	on	ADP
admet-782	43	27	day-1	day-1	NUM
admet-782	43	28	and	and	CCONJ
admet-782	43	29	day-15	day-15	PROPN
admet-782	43	30	)	)	PUNCT
admet-782	43	31	in	in	ADP
admet-782	43	32	patients	patient	NOUN
admet-782	43	33	with	with	ADP
admet-782	43	34	non	non	ADJ
admet-782	43	35	-	-	ADJ
admet-782	43	36	hodgkin	hodgkin	ADJ
admet-782	43	37	’s	’s	PART
admet-782	43	38	lymphoma	lymphoma	NOUN
admet-782	43	39	and	and	CCONJ
admet-782	43	40	advanced	advanced	ADJ
admet-782	43	41	solid	solid	ADJ
admet-782	43	42	tumors	tumor	NOUN
admet-782	43	43	[	[	X
admet-782	43	44	10,11	10,11	NOUN
admet-782	43	45	]	]	PUNCT
admet-782	43	46	.	.	PUNCT
admet-782	44	1	by	by	ADP
admet-782	44	2	achieving	achieve	VERB
admet-782	44	3	50	50	NUM
admet-782	44	4	ng	ng	NOUN
admet-782	44	5	/	/	SYM
admet-782	44	6	ml	ml	NOUN
admet-782	44	7	sensitivity	sensitivity	NOUN
admet-782	44	8	for	for	ADP
admet-782	44	9	copanlisib	copanlisib	PROPN
admet-782	44	10	on	on	ADP
admet-782	44	11	hplc	hplc	NOUN
admet-782	44	12	-	-	PUNCT
admet-782	44	13	uv	uv	NOUN
admet-782	44	14	,	,	PUNCT
admet-782	44	15	we	we	PRON
admet-782	44	16	believe	believe	VERB
admet-782	44	17	our	our	PRON
admet-782	44	18	present	present	ADJ
admet-782	44	19	method	method	NOUN
admet-782	44	20	can	can	AUX
admet-782	44	21	be	be	AUX
admet-782	44	22	used	use	VERB
admet-782	44	23	in	in	ADP
admet-782	44	24	hospitals	hospital	NOUN
admet-782	44	25	for	for	ADP
admet-782	44	26	routine	routine	ADJ
admet-782	44	27	therapeutic	therapeutic	ADJ
admet-782	44	28	drug	drug	NOUN
admet-782	44	29	monitoring	monitoring	NOUN
admet-782	44	30	of	of	ADP
admet-782	44	31	copanlisib	copanlisib	PROPN
admet-782	44	32	.	.	PUNCT
admet-782	45	1	besides	besides	SCONJ
admet-782	45	2	,	,	PUNCT
admet-782	45	3	the	the	DET
admet-782	45	4	proposed	propose	VERB
admet-782	45	5	method	method	NOUN
admet-782	45	6	can	can	AUX
admet-782	45	7	also	also	ADV
admet-782	45	8	be	be	AUX
admet-782	45	9	in	in	ADP
admet-782	45	10	research	research	NOUN
admet-782	45	11	laboratories	laboratory	NOUN
admet-782	45	12	for	for	ADP
admet-782	45	13	routine	routine	ADJ
admet-782	45	14	pharmacokinetic	pharmacokinetic	ADJ
admet-782	45	15	and/or	and/or	CCONJ
admet-782	45	16	toxicokinetic	toxicokinetic	ADJ
admet-782	45	17	studies	study	NOUN
admet-782	45	18	samples	sample	VERB
admet-782	45	19	analysis	analysis	NOUN
admet-782	45	20	.	.	PUNCT
admet-782	46	1	in	in	ADP
admet-782	46	2	order	order	NOUN
admet-782	46	3	to	to	PART
admet-782	46	4	ensure	ensure	VERB
admet-782	46	5	the	the	DET
admet-782	46	6	reliability	reliability	NOUN
admet-782	46	7	,	,	PUNCT
admet-782	46	8	reproducibility	reproducibility	NOUN
admet-782	46	9	and	and	CCONJ
admet-782	46	10	sensitivity	sensitivity	NOUN
admet-782	46	11	of	of	ADP
admet-782	46	12	the	the	DET
admet-782	46	13	method	method	NOUN
admet-782	46	14	,	,	PUNCT
admet-782	46	15	the	the	DET
admet-782	46	16	developed	develop	VERB
admet-782	46	17	analytical	analytical	ADJ
admet-782	46	18	method	method	NOUN
admet-782	46	19	was	be	AUX
admet-782	46	20	validated	validate	VERB
admet-782	46	21	for	for	ADP
admet-782	46	22	various	various	ADJ
admet-782	46	23	parameters	parameter	NOUN
admet-782	46	24	in	in	ADP
admet-782	46	25	accordance	accordance	NOUN
admet-782	46	26	with	with	ADP
admet-782	46	27	fda	fda	PROPN
admet-782	46	28	guideline	guideline	NOUN
admet-782	46	29	.	.	PUNCT
admet-782	47	1	the	the	DET
admet-782	47	2	validated	validate	VERB
admet-782	47	3	method	method	NOUN
admet-782	47	4	was	be	AUX
admet-782	47	5	applied	apply	VERB
admet-782	47	6	to	to	PART
admet-782	47	7	investigate	investigate	VERB
admet-782	47	8	the	the	DET
admet-782	47	9	pharmacokinetics	pharmacokinetic	NOUN
admet-782	47	10	of	of	ADP
admet-782	47	11	copanlisib	copanlisib	PROPN
admet-782	47	12	post	post	VERB
admet-782	47	13	intravenous	intravenous	ADJ
admet-782	47	14	administration	administration	NOUN
admet-782	47	15	to	to	ADP
admet-782	47	16	mice	mouse	NOUN
admet-782	47	17	.	.	PUNCT
admet-782	48	1	admet	admet	PROPN
admet-782	48	2	&	&	CCONJ
admet-782	48	3	dmpk	dmpk	PROPN
admet-782	48	4	8(1	8(1	NOUN
admet-782	48	5	)	)	PUNCT
admet-782	48	6	(	(	PUNCT
admet-782	48	7	2020	2020	NUM
admet-782	48	8	)	)	PUNCT
admet-782	48	9	113	113	NUM
admet-782	48	10	-	-	SYM
admet-782	48	11	121	121	NUM
admet-782	48	12	copanlisib	copanlisib	NOUN
admet-782	48	13	quantification	quantification	NOUN
admet-782	48	14	by	by	ADP
admet-782	48	15	hplc	hplc	NOUN
admet-782	48	16	in	in	ADP
admet-782	48	17	mice	mice	NOUN
admet-782	48	18	plasma	plasma	NOUN
admet-782	48	19	doi	doi	PROPN
admet-782	48	20	:	:	PUNCT
admet-782	48	21	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	NOUN
admet-782	48	22	115	115	NUM
admet-782	48	23	materials	material	NOUN
admet-782	48	24	and	and	CCONJ
admet-782	48	25	methods	method	NOUN
admet-782	48	26	chemicals	chemical	NOUN
admet-782	48	27	and	and	CCONJ
admet-782	48	28	reagents	reagent	NOUN
admet-782	48	29	copanlisib	copanlisib	VERB
admet-782	48	30	(	(	PUNCT
admet-782	48	31	purity	purity	NOUN
admet-782	48	32	:	:	PUNCT
admet-782	48	33	99.7	99.7	NUM
admet-782	48	34	%	%	NOUN
admet-782	48	35	)	)	PUNCT
admet-782	48	36	was	be	AUX
admet-782	48	37	obtained	obtain	VERB
admet-782	48	38	from	from	ADP
admet-782	48	39	beijing	beijing	PROPN
admet-782	48	40	yibai	yibai	PROPN
admet-782	48	41	biotechnology	biotechnology	PROPN
admet-782	48	42	co.	co.	PROPN
admet-782	48	43	,	,	PUNCT
admet-782	48	44	ltd	ltd	PROPN
admet-782	48	45	,	,	PUNCT
admet-782	48	46	beijing	beijing	PROPN
admet-782	48	47	,	,	PUNCT
admet-782	48	48	china	china	PROPN
admet-782	48	49	.	.	PUNCT
admet-782	48	50	enasidenib	enasidenib	PROPN
admet-782	48	51	(	(	PUNCT
admet-782	48	52	purity	purity	NOUN
admet-782	48	53	:	:	PUNCT
admet-782	48	54	98	98	NUM
admet-782	48	55	%	%	NOUN
admet-782	48	56	)	)	PUNCT
admet-782	48	57	used	use	VERB
admet-782	48	58	as	as	ADP
admet-782	48	59	an	an	DET
admet-782	48	60	internal	internal	ADJ
admet-782	48	61	standard	standard	NOUN
admet-782	48	62	(	(	PUNCT
admet-782	48	63	is	be	AUX
admet-782	48	64	)	)	PUNCT
admet-782	48	65	was	be	AUX
admet-782	48	66	purchased	purchase	VERB
admet-782	48	67	from	from	ADP
admet-782	48	68	aaron	aaron	PROPN
admet-782	48	69	,	,	PUNCT
admet-782	48	70	shanghai	shanghai	PROPN
admet-782	48	71	,	,	PUNCT
admet-782	48	72	china	china	PROPN
admet-782	48	73	.	.	PUNCT
admet-782	48	74	solutol	solutol	PROPN
admet-782	48	75	,	,	PUNCT
admet-782	48	76	ethanol	ethanol	NOUN
admet-782	48	77	and	and	CCONJ
admet-782	48	78	dimethyl	dimethyl	NOUN
admet-782	48	79	sulfoxide	sulfoxide	NOUN
admet-782	48	80	(	(	PUNCT
admet-782	48	81	dmso	dmso	NOUN
admet-782	48	82	)	)	PUNCT
admet-782	48	83	were	be	AUX
admet-782	48	84	purchased	purchase	VERB
admet-782	48	85	from	from	ADP
admet-782	48	86	sigma	sigma	PROPN
admet-782	48	87	-	-	PUNCT
admet-782	48	88	aldrich	aldrich	PROPN
admet-782	48	89	,	,	PUNCT
admet-782	48	90	st	st	PROPN
admet-782	48	91	.	.	PROPN
admet-782	48	92	louis	louis	PROPN
admet-782	48	93	,	,	PUNCT
admet-782	48	94	mo	mo	PROPN
admet-782	48	95	,	,	PUNCT
admet-782	48	96	usa	usa	PROPN
admet-782	48	97	.	.	PROPN
admet-782	48	98	hplc	hplc	PROPN
admet-782	48	99	grade	grade	NOUN
admet-782	48	100	acetonitrile	acetonitrile	NOUN
admet-782	48	101	and	and	CCONJ
admet-782	48	102	methanol	methanol	NOUN
admet-782	48	103	were	be	AUX
admet-782	48	104	purchased	purchase	VERB
admet-782	48	105	from	from	ADP
admet-782	48	106	j.t	j.t	PROPN
admet-782	48	107	.	.	PROPN
admet-782	48	108	baker	baker	PROPN
admet-782	48	109	avantor	avantor	PROPN
admet-782	48	110	,	,	PUNCT
admet-782	48	111	pa	pa	PROPN
admet-782	48	112	,	,	PUNCT
admet-782	48	113	usa	usa	PROPN
admet-782	48	114	.	.	PROPN
admet-782	48	115	analytical	analytical	ADJ
admet-782	48	116	grade	grade	PROPN
admet-782	48	117	hydrochloric	hydrochloric	ADJ
admet-782	48	118	acid	acid	NOUN
admet-782	48	119	and	and	CCONJ
admet-782	48	120	ammonium	ammonium	NOUN
admet-782	48	121	formate	formate	NOUN
admet-782	48	122	were	be	AUX
admet-782	48	123	purchased	purchase	VERB
admet-782	48	124	from	from	ADP
admet-782	48	125	s.d	s.d	PROPN
admet-782	48	126	.	.	PROPN
admet-782	48	127	fine	fine	ADJ
admet-782	48	128	chemicals	chemical	NOUN
admet-782	48	129	,	,	PUNCT
admet-782	48	130	mumbai	mumbai	PROPN
admet-782	48	131	,	,	PUNCT
admet-782	48	132	india	india	PROPN
admet-782	48	133	.	.	PUNCT
admet-782	49	1	all	all	DET
admet-782	49	2	other	other	ADJ
admet-782	49	3	chemicals	chemical	NOUN
admet-782	49	4	and	and	CCONJ
admet-782	49	5	reagents	reagent	NOUN
admet-782	49	6	were	be	AUX
admet-782	49	7	of	of	ADP
admet-782	49	8	analytical	analytical	ADJ
admet-782	49	9	grade	grade	NOUN
admet-782	49	10	and	and	CCONJ
admet-782	49	11	used	use	VERB
admet-782	49	12	without	without	ADP
admet-782	49	13	further	further	ADJ
admet-782	49	14	purification	purification	NOUN
admet-782	49	15	.	.	PUNCT
admet-782	50	1	the	the	DET
admet-782	50	2	control	control	NOUN
admet-782	50	3	mice	mouse	NOUN
admet-782	50	4	k2.edta	k2.edta	PUNCT
admet-782	50	5	plasma	plasma	NOUN
admet-782	50	6	was	be	AUX
admet-782	50	7	procured	procure	VERB
admet-782	50	8	from	from	ADP
admet-782	50	9	animal	animal	NOUN
admet-782	50	10	house	house	NOUN
admet-782	50	11	,	,	PUNCT
admet-782	50	12	jubilant	jubilant	ADJ
admet-782	50	13	biosys	biosy	NOUN
admet-782	50	14	,	,	PUNCT
admet-782	50	15	bangalore	bangalore	NOUN
admet-782	50	16	.	.	PUNCT
admet-782	51	1	hplc	hplc	NOUN
admet-782	51	2	operating	operating	NOUN
admet-782	51	3	conditions	condition	NOUN
admet-782	51	4	analysis	analysis	NOUN
admet-782	51	5	of	of	ADP
admet-782	51	6	copanlisib	copanlisib	PROPN
admet-782	51	7	in	in	ADP
admet-782	51	8	plasma	plasma	NOUN
admet-782	51	9	samples	sample	NOUN
admet-782	51	10	was	be	AUX
admet-782	51	11	performed	perform	VERB
admet-782	51	12	on	on	ADP
admet-782	51	13	a	a	DET
admet-782	51	14	waters	water	NOUN
admet-782	51	15	2695	2695	NUM
admet-782	51	16	alliance	alliance	NOUN
admet-782	51	17	hplc	hplc	NOUN
admet-782	51	18	system	system	NOUN
admet-782	51	19	(	(	PUNCT
admet-782	51	20	waters	water	NOUN
admet-782	51	21	,	,	PUNCT
admet-782	51	22	milford	milford	PROPN
admet-782	51	23	,	,	PUNCT
admet-782	51	24	usa	usa	PROPN
admet-782	51	25	)	)	PUNCT
admet-782	51	26	equipped	equip	VERB
admet-782	51	27	with	with	ADP
admet-782	51	28	performance	performance	NOUN
admet-782	51	29	plus	plus	CCONJ
admet-782	51	30	inline	inline	NOUN
admet-782	51	31	degasser	degasser	PROPN
admet-782	51	32	along	along	ADP
admet-782	51	33	with	with	ADP
admet-782	51	34	an	an	DET
admet-782	51	35	auto	auto	NOUN
admet-782	51	36	-	-	PUNCT
admet-782	51	37	sampler	sampler	NOUN
admet-782	51	38	,	,	PUNCT
admet-782	51	39	column	column	NOUN
admet-782	51	40	oven	oven	NOUN
admet-782	51	41	and	and	CCONJ
admet-782	51	42	photo	photo	NOUN
admet-782	51	43	diode	diode	NOUN
admet-782	51	44	array	array	NOUN
admet-782	51	45	(	(	PUNCT
admet-782	51	46	pda	pda	NOUN
admet-782	51	47	)	)	PUNCT
admet-782	51	48	detector	detector	NOUN
admet-782	51	49	set	set	VERB
admet-782	51	50	at	at	ADP
admet-782	51	51	max	max	NUM
admet-782	51	52	310	310	NUM
admet-782	51	53	nm	nm	NOUN
admet-782	51	54	.	.	PUNCT
admet-782	51	55	chromatographic	chromatographic	ADJ
admet-782	51	56	resolution	resolution	NOUN
admet-782	51	57	of	of	ADP
admet-782	51	58	copanlisib	copanlisib	PROPN
admet-782	51	59	and	and	CCONJ
admet-782	51	60	the	the	DET
admet-782	51	61	internal	internal	ADJ
admet-782	51	62	standard	standard	NOUN
admet-782	51	63	(	(	PUNCT
admet-782	51	64	is	be	AUX
admet-782	51	65	)	)	PUNCT
admet-782	51	66	was	be	AUX
admet-782	51	67	achieved	achieve	VERB
admet-782	51	68	by	by	ADP
admet-782	51	69	injecting	inject	VERB
admet-782	51	70	25	25	NUM
admet-782	51	71	µl	µl	NOUN
admet-782	51	72	of	of	ADP
admet-782	51	73	the	the	DET
admet-782	51	74	processed	process	VERB
admet-782	51	75	sample	sample	NOUN
admet-782	51	76	on	on	ADP
admet-782	51	77	a	a	DET
admet-782	51	78	hypersil	hypersil	NOUN
admet-782	51	79	gold	gold	NOUN
admet-782	51	80	c18	c18	NOUN
admet-782	51	81	column	column	NOUN
admet-782	51	82	(	(	PUNCT
admet-782	51	83	250	250	NUM
admet-782	51	84			NOUN
admet-782	51	85	4.0	4.0	NUM
admet-782	51	86	mm	mm	NOUN
admet-782	51	87	,	,	PUNCT
admet-782	51	88	5	5	NUM
admet-782	51	89	µm	µm	NUM
admet-782	51	90	;	;	PUNCT
admet-782	51	91	thermo	thermo	NOUN
admet-782	51	92	scientific	scientific	NOUN
admet-782	51	93	,	,	PUNCT
admet-782	51	94	usa	usa	PROPN
admet-782	51	95	)	)	PUNCT
admet-782	51	96	maintained	maintain	VERB
admet-782	51	97	at	at	ADP
admet-782	51	98	40±1	40±1	PROPN
admet-782	51	99	°	°	ADP
admet-782	51	100	c	c	NOUN
admet-782	51	101	using	use	VERB
admet-782	51	102	a	a	DET
admet-782	51	103	binary	binary	ADJ
admet-782	51	104	gradient	gradient	NOUN
admet-782	51	105	mobile	mobile	ADJ
admet-782	51	106	phase	phase	NOUN
admet-782	51	107	consisting	consist	VERB
admet-782	51	108	10	10	NUM
admet-782	51	109	mm	mm	NOUN
admet-782	51	110	ammonium	ammonium	NOUN
admet-782	51	111	formate	formate	NOUN
admet-782	51	112	,	,	PUNCT
admet-782	51	113	ph	ph	VERB
admet-782	51	114	:	:	PUNCT
admet-782	51	115	4.0	4.0	NUM
admet-782	51	116	(	(	PUNCT
admet-782	51	117	adjusted	adjust	VERB
admet-782	51	118	with	with	ADP
admet-782	51	119	formic	formic	ADJ
admet-782	51	120	acid	acid	NOUN
admet-782	51	121	)	)	PUNCT
admet-782	51	122	(	(	PUNCT
admet-782	51	123	solvent	solvent	NOUN
admet-782	51	124	a	a	NOUN
admet-782	51	125	)	)	PUNCT
admet-782	51	126	and	and	CCONJ
admet-782	51	127	acetonitrile	acetonitrile	NOUN
admet-782	51	128	(	(	PUNCT
admet-782	51	129	solvent	solvent	NOUN
admet-782	51	130	b	b	NOUN
admet-782	51	131	)	)	PUNCT
admet-782	51	132	delivered	deliver	VERB
admet-782	51	133	at	at	ADP
admet-782	51	134	a	a	DET
admet-782	51	135	flow	flow	NOUN
admet-782	51	136	-	-	PUNCT
admet-782	51	137	rate	rate	NOUN
admet-782	51	138	of	of	ADP
admet-782	51	139	0.8	0.8	NUM
admet-782	51	140	ml	ml	NOUN
admet-782	51	141	/	/	SYM
admet-782	51	142	min	min	NOUN
admet-782	51	143	.	.	PROPN
admet-782	51	144	initial	initial	ADJ
admet-782	51	145	eluent	eluent	NOUN
admet-782	51	146	composition	composition	NOUN
admet-782	51	147	was	be	AUX
admet-782	51	148	90	90	NUM
admet-782	51	149	%	%	NOUN
admet-782	51	150	a	a	PRON
admet-782	51	151	,	,	PUNCT
admet-782	51	152	maintained	maintain	VERB
admet-782	51	153	for	for	ADP
admet-782	51	154	5.0	5.0	NUM
admet-782	51	155	min	min	NOUN
admet-782	51	156	,	,	PUNCT
admet-782	51	157	and	and	CCONJ
admet-782	51	158	followed	follow	VERB
admet-782	51	159	by	by	ADP
admet-782	51	160	a	a	DET
admet-782	51	161	linear	linear	ADJ
admet-782	51	162	0.5	0.5	NUM
admet-782	51	163	min	min	NOUN
admet-782	51	164	ramp	ramp	NOUN
admet-782	51	165	to	to	ADP
admet-782	51	166	10	10	NUM
admet-782	51	167	%	%	NOUN
admet-782	51	168	a	a	PRON
admet-782	51	169	,	,	PUNCT
admet-782	51	170	which	which	PRON
admet-782	51	171	was	be	AUX
admet-782	51	172	maintained	maintain	VERB
admet-782	51	173	for	for	ADP
admet-782	51	174	until	until	ADP
admet-782	51	175	5.5	5.5	NUM
admet-782	51	176	min	min	NOUN
admet-782	51	177	.	.	PUNCT
admet-782	52	1	the	the	DET
admet-782	52	2	mobile	mobile	ADJ
admet-782	52	3	phase	phase	NOUN
admet-782	52	4	composition	composition	NOUN
admet-782	52	5	returned	return	VERB
admet-782	52	6	to	to	ADP
admet-782	52	7	90	90	NUM
admet-782	52	8	%	%	NOUN
admet-782	52	9	a	a	PRON
admet-782	52	10	at	at	ADP
admet-782	52	11	8.0	8.0	NUM
admet-782	52	12	min	min	NOUN
admet-782	52	13	.	.	PROPN
admet-782	52	14	equilibration	equilibration	NOUN
admet-782	52	15	time	time	NOUN
admet-782	52	16	was	be	AUX
admet-782	52	17	2.0	2.0	NUM
admet-782	52	18	min	min	NOUN
admet-782	52	19	.	.	PROPN
admet-782	52	20	preparation	preparation	NOUN
admet-782	52	21	of	of	ADP
admet-782	52	22	stock	stock	NOUN
admet-782	52	23	solutions	solution	NOUN
admet-782	52	24	for	for	ADP
admet-782	52	25	copanlisib	copanlisib	PROPN
admet-782	52	26	and	and	CCONJ
admet-782	52	27	the	the	PRON
admet-782	52	28	is	be	AUX
admet-782	52	29	for	for	ADP
admet-782	52	30	the	the	DET
admet-782	52	31	preparation	preparation	NOUN
admet-782	52	32	of	of	ADP
admet-782	52	33	calibration	calibration	NOUN
admet-782	52	34	curve	curve	NOUN
admet-782	52	35	(	(	PUNCT
admet-782	52	36	cc	cc	NOUN
admet-782	52	37	)	)	PUNCT
admet-782	52	38	and	and	CCONJ
admet-782	52	39	quality	quality	NOUN
admet-782	52	40	control	control	NOUN
admet-782	52	41	(	(	PUNCT
admet-782	52	42	qc	qc	PROPN
admet-782	52	43	)	)	PUNCT
admet-782	52	44	samples	sample	NOUN
admet-782	52	45	,	,	PUNCT
admet-782	52	46	two	two	NUM
admet-782	52	47	primary	primary	ADJ
admet-782	52	48	stock	stock	NOUN
admet-782	52	49	solutions	solution	NOUN
admet-782	52	50	of	of	ADP
admet-782	52	51	copanlisib	copanlisib	PROPN
admet-782	52	52	were	be	AUX
admet-782	52	53	made	make	VERB
admet-782	52	54	at	at	ADP
admet-782	52	55	1.0	1.0	NUM
admet-782	52	56	mg	mg	NUM
admet-782	52	57	/	/	SYM
admet-782	52	58	ml	ml	NOUN
admet-782	52	59	in	in	ADP
admet-782	52	60	0.1	0.1	NUM
admet-782	52	61	n	n	PRON
admet-782	52	62	hcl	hcl	NOUN
admet-782	52	63	:	:	PUNCT
admet-782	52	64	dmso	dmso	NOUN
admet-782	52	65	(	(	PUNCT
admet-782	52	66	2:98	2:98	NUM
admet-782	52	67	,	,	PUNCT
admet-782	52	68	v	v	NOUN
admet-782	52	69	/	/	SYM
admet-782	52	70	v	v	NOUN
admet-782	52	71	)	)	PUNCT
admet-782	52	72	.	.	PUNCT
admet-782	53	1	due	due	ADP
admet-782	53	2	to	to	ADP
admet-782	53	3	copanlisib	copanlisib	PROPN
admet-782	53	4	limited	limit	VERB
admet-782	53	5	solubility	solubility	NOUN
admet-782	53	6	in	in	ADP
admet-782	53	7	organic	organic	ADJ
admet-782	53	8	solvents	solvent	NOUN
admet-782	53	9	we	we	PRON
admet-782	53	10	have	have	AUX
admet-782	53	11	used	use	VERB
admet-782	53	12	0.1	0.1	NUM
admet-782	53	13	n	n	PRON
admet-782	53	14	hcl	hcl	PROPN
admet-782	53	15	.	.	PUNCT
admet-782	54	1	the	the	DET
admet-782	54	2	primary	primary	ADJ
admet-782	54	3	stock	stock	NOUN
admet-782	54	4	solution	solution	NOUN
admet-782	54	5	of	of	ADP
admet-782	54	6	the	the	DET
admet-782	54	7	is	is	NOUN
admet-782	54	8	(	(	PUNCT
admet-782	54	9	1.0	1.0	NUM
admet-782	54	10	mg	mg	NUM
admet-782	54	11	/	/	SYM
admet-782	54	12	ml	ml	NOUN
admet-782	54	13	)	)	PUNCT
admet-782	54	14	was	be	AUX
admet-782	54	15	prepared	prepare	VERB
admet-782	54	16	in	in	ADP
admet-782	54	17	dmso	dmso	NOUN
admet-782	54	18	and	and	CCONJ
admet-782	54	19	subsequently	subsequently	ADV
admet-782	54	20	diluted	dilute	VERB
admet-782	54	21	with	with	ADP
admet-782	54	22	80	80	NUM
admet-782	54	23	%	%	NOUN
admet-782	54	24	methanol	methanol	NOUN
admet-782	54	25	to	to	PART
admet-782	54	26	get	get	VERB
admet-782	54	27	work	work	NOUN
admet-782	54	28	stock	stock	NOUN
admet-782	54	29	at	at	ADP
admet-782	54	30	0.60	0.60	NUM
admet-782	54	31	μg	μg	NOUN
admet-782	54	32	/	/	SYM
admet-782	54	33	ml	ml	PROPN
admet-782	54	34	.	.	PUNCT
admet-782	55	1	the	the	DET
admet-782	55	2	primary	primary	ADJ
admet-782	55	3	stock	stock	NOUN
admet-782	55	4	solutions	solution	NOUN
admet-782	55	5	of	of	ADP
admet-782	55	6	copanlisib	copanlisib	PROPN
admet-782	55	7	and	and	CCONJ
admet-782	55	8	the	the	PRON
admet-782	55	9	is	be	AUX
admet-782	55	10	were	be	AUX
admet-782	55	11	stored	store	VERB
admet-782	55	12	at	at	ADP
admet-782	55	13	-20±5	-20±5	NOUN
admet-782	55	14	°	°	ADP
admet-782	55	15	c	c	NOUN
admet-782	55	16	,	,	PUNCT
admet-782	55	17	which	which	PRON
admet-782	55	18	were	be	AUX
admet-782	55	19	found	find	VERB
admet-782	55	20	to	to	PART
admet-782	55	21	be	be	AUX
admet-782	55	22	stable	stable	ADJ
admet-782	55	23	for	for	ADP
admet-782	55	24	50	50	NUM
admet-782	55	25	days	day	NOUN
admet-782	55	26	.	.	PUNCT
admet-782	56	1	preparation	preparation	NOUN
admet-782	56	2	of	of	ADP
admet-782	56	3	calibration	calibration	NOUN
admet-782	56	4	curve	curve	NOUN
admet-782	56	5	standards	standard	NOUN
admet-782	56	6	and	and	CCONJ
admet-782	56	7	quality	quality	NOUN
admet-782	56	8	control	control	NOUN
admet-782	56	9	samples	sample	VERB
admet-782	56	10	the	the	DET
admet-782	56	11	first	first	ADJ
admet-782	56	12	set	set	NOUN
admet-782	56	13	of	of	ADP
admet-782	56	14	primary	primary	ADJ
admet-782	56	15	stock	stock	NOUN
admet-782	56	16	solution	solution	NOUN
admet-782	56	17	of	of	ADP
admet-782	56	18	copanlisib	copanlisib	PROPN
admet-782	56	19	was	be	AUX
admet-782	56	20	diluted	dilute	VERB
admet-782	56	21	appropriately	appropriately	ADV
admet-782	56	22	and	and	CCONJ
admet-782	56	23	subsequently	subsequently	ADV
admet-782	56	24	used	use	VERB
admet-782	56	25	to	to	PART
admet-782	56	26	prepare	prepare	VERB
admet-782	56	27	a	a	DET
admet-782	56	28	calibration	calibration	NOUN
admet-782	56	29	curve	curve	NOUN
admet-782	56	30	(	(	PUNCT
admet-782	56	31	cc	cc	NOUN
admet-782	56	32	)	)	PUNCT
admet-782	56	33	standards	standard	NOUN
admet-782	56	34	.	.	PUNCT
admet-782	57	1	the	the	DET
admet-782	57	2	calibration	calibration	NOUN
admet-782	57	3	standard	standard	ADJ
admet-782	57	4	samples	sample	NOUN
admet-782	57	5	were	be	AUX
admet-782	57	6	made	make	VERB
admet-782	57	7	by	by	ADP
admet-782	57	8	spiking	spike	VERB
admet-782	57	9	the	the	DET
admet-782	57	10	blank	blank	ADJ
admet-782	57	11	mice	mice	NOUN
admet-782	57	12	plasma	plasma	NOUN
admet-782	57	13	(	(	PUNCT
admet-782	57	14	90	90	NUM
admet-782	57	15	µl	µl	NOUN
admet-782	57	16	)	)	PUNCT
admet-782	57	17	with	with	ADP
admet-782	57	18	each	each	DET
admet-782	57	19	corresponding	correspond	VERB
admet-782	57	20	working	working	ADJ
admet-782	57	21	solution	solution	NOUN
admet-782	57	22	of	of	ADP
admet-782	57	23	copanlisib	copanlisib	PROPN
admet-782	57	24	(	(	PUNCT
admet-782	57	25	10	10	NUM
admet-782	57	26	µl	µl	NOUN
admet-782	57	27	)	)	PUNCT
admet-782	57	28	thereby	thereby	ADV
admet-782	57	29	yielding	yield	VERB
admet-782	57	30	final	final	ADJ
admet-782	57	31	concentrations	concentration	NOUN
admet-782	57	32	of	of	ADP
admet-782	57	33	50	50	NUM
admet-782	57	34	,	,	PUNCT
admet-782	57	35	100	100	NUM
admet-782	57	36	,	,	PUNCT
admet-782	57	37	500	500	NUM
admet-782	57	38	,	,	PUNCT
admet-782	57	39	750	750	NUM
admet-782	57	40	,	,	PUNCT
admet-782	57	41	1250	1250	NUM
admet-782	57	42	,	,	PUNCT
admet-782	57	43	2500	2500	NUM
admet-782	57	44	,	,	PUNCT
admet-782	57	45	3750	3750	NUM
admet-782	57	46	and	and	CCONJ
admet-782	57	47	5000	5000	NUM
admet-782	57	48	ng	ng	NOUN
admet-782	57	49	/	/	SYM
admet-782	57	50	ml	ml	PROPN
admet-782	57	51	.	.	PUNCT
admet-782	58	1	for	for	ADP
admet-782	58	2	the	the	DET
admet-782	58	3	determination	determination	NOUN
admet-782	58	4	of	of	ADP
admet-782	58	5	precision	precision	NOUN
admet-782	58	6	and	and	CCONJ
admet-782	58	7	accuracy	accuracy	NOUN
admet-782	58	8	,	,	PUNCT
admet-782	58	9	samples	sample	NOUN
admet-782	58	10	were	be	AUX
admet-782	58	11	prepared	prepare	VERB
admet-782	58	12	by	by	ADP
admet-782	58	13	spiking	spike	VERB
admet-782	58	14	blank	blank	ADJ
admet-782	58	15	mice	mouse	NOUN
admet-782	58	16	plasma	plasma	NOUN
admet-782	58	17	in	in	ADP
admet-782	58	18	bulk	bulk	NOUN
admet-782	58	19	with	with	ADP
admet-782	58	20	the	the	DET
admet-782	58	21	second	second	ADJ
admet-782	58	22	working	work	VERB
admet-782	58	23	stock	stock	NOUN
admet-782	58	24	solution	solution	NOUN
admet-782	58	25	of	of	ADP
admet-782	58	26	copanlisib	copanlisib	PROPN
admet-782	58	27	at	at	ADP
admet-782	58	28	appropriate	appropriate	ADJ
admet-782	58	29	concentrations	concentration	NOUN
admet-782	58	30	and	and	CCONJ
admet-782	58	31	100	100	NUM
admet-782	58	32	l	l	NOUN
admet-782	58	33	aliquots	aliquot	NOUN
admet-782	58	34	were	be	AUX
admet-782	58	35	distributed	distribute	VERB
admet-782	58	36	into	into	ADP
admet-782	58	37	different	different	ADJ
admet-782	58	38	tubes	tube	NOUN
admet-782	58	39	.	.	PUNCT
admet-782	59	1	the	the	DET
admet-782	59	2	qcs	qcs	PROPN
admet-782	59	3	prepared	prepare	VERB
admet-782	59	4	were	be	AUX
admet-782	59	5	:	:	PUNCT
admet-782	59	6	50	50	NUM
admet-782	59	7	ng	ng	NOUN
admet-782	59	8	/	/	SYM
admet-782	59	9	ml	ml	PROPN
admet-782	59	10	(	(	PUNCT
admet-782	59	11	lower	low	ADJ
admet-782	59	12	limit	limit	NOUN
admet-782	59	13	of	of	ADP
admet-782	59	14	quantification	quantification	NOUN
admet-782	59	15	quality	quality	NOUN
admet-782	59	16	control	control	NOUN
admet-782	59	17	;	;	PUNCT
admet-782	59	18	lloq	lloq	PROPN
admet-782	59	19	qc	qc	PROPN
admet-782	59	20	)	)	PUNCT
admet-782	59	21	,	,	PUNCT
admet-782	59	22	150	150	NUM
admet-782	59	23	ng	ng	NOUN
admet-782	59	24	/	/	SYM
admet-782	59	25	ml	ml	PROPN
admet-782	59	26	(	(	PUNCT
admet-782	59	27	low	low	ADJ
admet-782	59	28	quality	quality	NOUN
admet-782	59	29	control	control	NOUN
admet-782	59	30	;	;	PUNCT
admet-782	59	31	lqc	lqc	PROPN
admet-782	59	32	)	)	PUNCT
admet-782	59	33	,	,	PUNCT
admet-782	59	34	2250	2250	NUM
admet-782	59	35	ng	ng	PROPN
admet-782	59	36	/	/	SYM
admet-782	59	37	ml	ml	PROPN
admet-782	59	38	(	(	PUNCT
admet-782	59	39	medium	medium	ADJ
admet-782	59	40	quality	quality	NOUN
admet-782	59	41	control	control	NOUN
admet-782	59	42	;	;	PUNCT
admet-782	59	43	mqc	mqc	PROPN
admet-782	59	44	)	)	PUNCT
admet-782	59	45	and	and	CCONJ
admet-782	59	46	3500	3500	NUM
admet-782	59	47	ng	ng	PROPN
admet-782	59	48	/	/	SYM
admet-782	59	49	ml	ml	PROPN
admet-782	59	50	(	(	PUNCT
admet-782	59	51	high	high	ADJ
admet-782	59	52	quality	quality	NOUN
admet-782	59	53	control	control	NOUN
admet-782	59	54	;	;	PUNCT
admet-782	59	55	hqc	hqc	PROPN
admet-782	59	56	)	)	PUNCT
admet-782	59	57	.	.	PUNCT
admet-782	60	1	all	all	DET
admet-782	60	2	the	the	DET
admet-782	60	3	qcs	qcs	PROPN
admet-782	60	4	were	be	AUX
admet-782	60	5	stored	store	VERB
admet-782	60	6	together	together	ADV
admet-782	60	7	at	at	ADP
admet-782	60	8	-80±10	-80±10	PROPN
admet-782	60	9	°	°	PROPN
admet-782	60	10	c	c	NOUN
admet-782	60	11	until	until	ADP
admet-782	60	12	analysis	analysis	NOUN
admet-782	60	13	.	.	PUNCT
admet-782	61	1	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	61	2	r.	r.	PROPN
admet-782	61	3	mullangi	mullangi	VERB
admet-782	61	4	et	et	PROPN
admet-782	61	5	al	al	PROPN
admet-782	61	6	.	.	PROPN
admet-782	61	7	admet	admet	PROPN
admet-782	61	8	&	&	CCONJ
admet-782	61	9	dmpk	dmpk	PROPN
admet-782	61	10	8(1	8(1	NOUN
admet-782	61	11	)	)	PUNCT
admet-782	61	12	(	(	PUNCT
admet-782	61	13	2020	2020	NUM
admet-782	61	14	)	)	PUNCT
admet-782	61	15	113	113	NUM
admet-782	61	16	-	-	SYM
admet-782	61	17	121	121	NUM
admet-782	61	18	116	116	NUM
admet-782	61	19	sample	sample	NOUN
admet-782	61	20	preparation	preparation	NOUN
admet-782	61	21	to	to	ADP
admet-782	61	22	an	an	DET
admet-782	61	23	aliquot	aliquot	NOUN
admet-782	61	24	of	of	ADP
admet-782	61	25	100	100	NUM
admet-782	61	26	µl	µl	ADP
admet-782	61	27	mice	mice	NOUN
admet-782	61	28	plasma	plasma	NOUN
admet-782	61	29	sample	sample	NOUN
admet-782	61	30	,	,	PUNCT
admet-782	61	31	1.0	1.0	NUM
admet-782	61	32	ml	ml	NOUN
admet-782	61	33	of	of	ADP
admet-782	61	34	ethyl	ethyl	PROPN
admet-782	61	35	acetate	acetate	PROPN
admet-782	61	36	was	be	AUX
admet-782	61	37	added	add	VERB
admet-782	61	38	and	and	CCONJ
admet-782	61	39	vortex	vortex	NOUN
admet-782	61	40	mixed	mix	VERB
admet-782	61	41	for	for	ADP
admet-782	61	42	3	3	NUM
admet-782	61	43	min	min	NOUN
admet-782	61	44	;	;	PUNCT
admet-782	61	45	followed	follow	VERB
admet-782	61	46	by	by	ADP
admet-782	61	47	centrifugation	centrifugation	NOUN
admet-782	61	48	for	for	ADP
admet-782	61	49	5	5	NUM
admet-782	61	50	min	min	NOUN
admet-782	61	51	at	at	ADP
admet-782	61	52	14,000	14,000	NUM
admet-782	61	53	rpm	rpm	NOUN
admet-782	61	54	in	in	ADP
admet-782	61	55	a	a	DET
admet-782	61	56	refrigerated	refrigerate	VERB
admet-782	61	57	centrifuge	centrifuge	NOUN
admet-782	61	58	(	(	PUNCT
admet-782	61	59	eppendorf	eppendorf	PROPN
admet-782	61	60	5424r	5424r	NUM
admet-782	61	61	)	)	PUNCT
admet-782	61	62	maintained	maintain	VERB
admet-782	61	63	at	at	ADP
admet-782	61	64	5	5	NUM
admet-782	61	65	°	°	NOUN
admet-782	61	66	c	c	NOUN
admet-782	61	67	.	.	PUNCT
admet-782	62	1	the	the	DET
admet-782	62	2	organic	organic	ADJ
admet-782	62	3	layer	layer	NOUN
admet-782	62	4	(	(	PUNCT
admet-782	62	5	800	800	NUM
admet-782	62	6	µl	µl	NOUN
admet-782	62	7	)	)	PUNCT
admet-782	62	8	was	be	AUX
admet-782	62	9	separated	separate	VERB
admet-782	62	10	and	and	CCONJ
admet-782	62	11	evaporated	evaporate	VERB
admet-782	62	12	to	to	PART
admet-782	62	13	dryness	dryness	VERB
admet-782	62	14	at	at	ADP
admet-782	62	15	50	50	NUM
admet-782	62	16	°	°	ADP
admet-782	62	17	c	c	NOUN
admet-782	62	18	using	use	VERB
admet-782	62	19	a	a	DET
admet-782	62	20	gentle	gentle	ADJ
admet-782	62	21	stream	stream	NOUN
admet-782	62	22	of	of	ADP
admet-782	62	23	nitrogen	nitrogen	NOUN
admet-782	62	24	(	(	PUNCT
admet-782	62	25	turbovap	turbovap	PROPN
admet-782	62	26	®	®	PROPN
admet-782	62	27	,	,	PUNCT
admet-782	62	28	zymark	zymark	PROPN
admet-782	62	29	®	®	PROPN
admet-782	62	30	,	,	PUNCT
admet-782	62	31	kopkinton	kopkinton	PROPN
admet-782	62	32	,	,	PUNCT
admet-782	62	33	ma	ma	PROPN
admet-782	62	34	,	,	PUNCT
admet-782	62	35	usa	usa	PROPN
admet-782	62	36	)	)	PUNCT
admet-782	62	37	.	.	PUNCT
admet-782	63	1	the	the	DET
admet-782	63	2	residue	residue	NOUN
admet-782	63	3	was	be	AUX
admet-782	63	4	reconstituted	reconstitute	VERB
admet-782	63	5	in	in	ADP
admet-782	63	6	100	100	NUM
admet-782	63	7	µl	µl	NOUN
admet-782	63	8	of	of	ADP
admet-782	63	9	the	the	PRON
admet-782	63	10	is	be	AUX
admet-782	63	11	solution	solution	NOUN
admet-782	63	12	(	(	PUNCT
admet-782	63	13	600	600	NUM
admet-782	63	14	ng	ng	NOUN
admet-782	63	15	/	/	SYM
admet-782	63	16	ml	ml	PROPN
admet-782	63	17	)	)	PUNCT
admet-782	63	18	and	and	CCONJ
admet-782	63	19	25	25	NUM
admet-782	63	20	µl	µl	NOUN
admet-782	63	21	was	be	AUX
admet-782	63	22	injected	inject	VERB
admet-782	63	23	onto	onto	ADP
admet-782	63	24	hplc	hplc	NOUN
admet-782	63	25	system	system	NOUN
admet-782	63	26	for	for	ADP
admet-782	63	27	analysis	analysis	NOUN
admet-782	63	28	.	.	PUNCT
admet-782	64	1	validation	validation	NOUN
admet-782	64	2	procedures	procedure	NOUN
admet-782	64	3	a	a	DET
admet-782	64	4	full	full	ADJ
admet-782	64	5	validation	validation	NOUN
admet-782	64	6	according	accord	VERB
admet-782	64	7	to	to	ADP
admet-782	64	8	the	the	DET
admet-782	64	9	us	us	PROPN
admet-782	64	10	fda	fda	PROPN
admet-782	64	11	guidance	guidance	NOUN
admet-782	64	12	was	be	AUX
admet-782	64	13	performed	perform	VERB
admet-782	64	14	for	for	ADP
admet-782	64	15	the	the	DET
admet-782	64	16	quantitation	quantitation	NOUN
admet-782	64	17	of	of	ADP
admet-782	64	18	copanlisib	copanlisib	PROPN
admet-782	64	19	in	in	ADP
admet-782	64	20	mice	mice	NOUN
admet-782	64	21	plasma	plasma	NOUN
admet-782	64	22	[	[	X
admet-782	64	23	12	12	NUM
admet-782	64	24	]	]	PUNCT
admet-782	64	25	.	.	PUNCT
admet-782	65	1	the	the	DET
admet-782	65	2	selectivity	selectivity	NOUN
admet-782	65	3	of	of	ADP
admet-782	65	4	the	the	DET
admet-782	65	5	proposed	propose	VERB
admet-782	65	6	method	method	NOUN
admet-782	65	7	was	be	AUX
admet-782	65	8	assessed	assess	VERB
admet-782	65	9	by	by	ADP
admet-782	65	10	evaluating	evaluate	VERB
admet-782	65	11	the	the	DET
admet-782	65	12	presence	presence	NOUN
admet-782	65	13	of	of	ADP
admet-782	65	14	interfering	interfere	VERB
admet-782	65	15	the	the	DET
admet-782	65	16	peaks	peak	NOUN
admet-782	65	17	at	at	ADP
admet-782	65	18	the	the	DET
admet-782	65	19	retention	retention	NOUN
admet-782	65	20	times	time	NOUN
admet-782	65	21	of	of	ADP
admet-782	65	22	copanlisib	copanlisib	PROPN
admet-782	65	23	and	and	CCONJ
admet-782	65	24	the	the	PRON
admet-782	65	25	is	be	AUX
admet-782	65	26	in	in	ADP
admet-782	65	27	six	six	NUM
admet-782	65	28	different	different	ADJ
admet-782	65	29	batches	batch	NOUN
admet-782	65	30	of	of	ADP
admet-782	65	31	blank	blank	ADJ
admet-782	65	32	mice	mice	NOUN
admet-782	65	33	plasma	plasma	NOUN
admet-782	65	34	samples	sample	NOUN
admet-782	65	35	.	.	PUNCT
admet-782	66	1	the	the	DET
admet-782	66	2	auto	auto	NOUN
admet-782	66	3	-	-	PUNCT
admet-782	66	4	injector	injector	NOUN
admet-782	66	5	carry	carry	NOUN
admet-782	66	6	over	over	ADP
admet-782	66	7	was	be	AUX
admet-782	66	8	determined	determine	VERB
admet-782	66	9	by	by	ADP
admet-782	66	10	injecting	inject	VERB
admet-782	66	11	the	the	DET
admet-782	66	12	highest	high	ADJ
admet-782	66	13	calibration	calibration	NOUN
admet-782	66	14	standard	standard	NOUN
admet-782	66	15	(	(	PUNCT
admet-782	66	16	5.0	5.0	NUM
admet-782	66	17	µg	µg	NOUN
admet-782	66	18	/	/	SYM
admet-782	66	19	ml	ml	NOUN
admet-782	66	20	)	)	PUNCT
admet-782	66	21	followed	follow	VERB
admet-782	66	22	by	by	ADP
admet-782	66	23	injection	injection	NOUN
admet-782	66	24	of	of	ADP
admet-782	66	25	mice	mice	NOUN
admet-782	66	26	plasma	plasma	NOUN
admet-782	66	27	blank	blank	ADJ
admet-782	66	28	samples	sample	NOUN
admet-782	66	29	.	.	PUNCT
admet-782	67	1	recovery	recovery	NOUN
admet-782	67	2	of	of	ADP
admet-782	67	3	copanlisib	copanlisib	PROPN
admet-782	67	4	was	be	AUX
admet-782	67	5	determined	determine	VERB
admet-782	67	6	by	by	ADP
admet-782	67	7	comparing	compare	VERB
admet-782	67	8	their	their	PRON
admet-782	67	9	respective	respective	ADJ
admet-782	67	10	response	response	NOUN
admet-782	67	11	from	from	ADP
admet-782	67	12	qcs	qcs	PROPN
admet-782	67	13	(	(	PUNCT
admet-782	67	14	lqc	lqc	NOUN
admet-782	67	15	and	and	CCONJ
admet-782	67	16	hqc	hqc	INTJ
admet-782	67	17	)	)	PUNCT
admet-782	67	18	after	after	ADP
admet-782	67	19	the	the	DET
admet-782	67	20	extraction	extraction	NOUN
admet-782	67	21	process	process	NOUN
admet-782	67	22	against	against	ADP
admet-782	67	23	their	their	PRON
admet-782	67	24	non	non	ADJ
admet-782	67	25	-	-	ADJ
admet-782	67	26	extracted	extract	VERB
admet-782	67	27	samples	sample	NOUN
admet-782	67	28	.	.	PUNCT
admet-782	68	1	recovery	recovery	NOUN
admet-782	68	2	of	of	ADP
admet-782	68	3	the	the	PRON
admet-782	68	4	is	be	AUX
admet-782	68	5	was	be	AUX
admet-782	68	6	determined	determine	VERB
admet-782	68	7	at	at	ADP
admet-782	68	8	600	600	NUM
admet-782	68	9	ng	ng	NOUN
admet-782	68	10	/	/	SYM
admet-782	68	11	ml	ml	PROPN
admet-782	69	1	.	.	PUNCT
admet-782	69	2	intraand	intraand	PROPN
admet-782	69	3	inter	inter	ADJ
admet-782	69	4	-	-	ADJ
admet-782	69	5	day	day	NOUN
admet-782	69	6	accuracy	accuracy	NOUN
admet-782	69	7	and	and	CCONJ
admet-782	69	8	precision	precision	NOUN
admet-782	69	9	were	be	AUX
admet-782	69	10	determined	determine	VERB
admet-782	69	11	at	at	ADP
admet-782	69	12	four	four	NUM
admet-782	69	13	qc	qc	PROPN
admet-782	69	14	levels	level	NOUN
admet-782	69	15	[	[	X
admet-782	69	16	lloq	lloq	PROPN
admet-782	69	17	qc	qc	PROPN
admet-782	69	18	(	(	PUNCT
admet-782	69	19	50	50	NUM
admet-782	69	20	ng	ng	PROPN
admet-782	69	21	/	/	SYM
admet-782	69	22	ml	ml	PROPN
admet-782	69	23	)	)	PUNCT
admet-782	69	24	,	,	PUNCT
admet-782	69	25	lqc	lqc	INTJ
admet-782	69	26	(	(	PUNCT
admet-782	69	27	150	150	NUM
admet-782	69	28	ng	ng	NOUN
admet-782	69	29	/	/	SYM
admet-782	69	30	ml	ml	PROPN
admet-782	69	31	)	)	PUNCT
admet-782	69	32	,	,	PUNCT
admet-782	69	33	mqc	mqc	X
admet-782	69	34	(	(	PUNCT
admet-782	69	35	2250	2250	NUM
admet-782	69	36	ng	ng	PROPN
admet-782	69	37	/	/	SYM
admet-782	69	38	ml	ml	PROPN
admet-782	69	39	)	)	PUNCT
admet-782	69	40	and	and	CCONJ
admet-782	69	41	hqc	hqc	INTJ
admet-782	69	42	(	(	PUNCT
admet-782	69	43	3500	3500	NUM
admet-782	69	44	ng	ng	PROPN
admet-782	69	45	/	/	SYM
admet-782	69	46	ml	ml	PROPN
admet-782	69	47	)	)	PUNCT
admet-782	69	48	]	]	PUNCT
admet-782	69	49	along	along	ADP
admet-782	69	50	with	with	ADP
admet-782	69	51	calibration	calibration	NOUN
admet-782	69	52	curve	curve	NOUN
admet-782	69	53	(	(	PUNCT
admet-782	69	54	0.05	0.05	NUM
admet-782	69	55	-	-	SYM
admet-782	69	56	5.00	5.00	NUM
admet-782	69	57	μg	μg	NOUN
admet-782	69	58	/	/	SYM
admet-782	69	59	ml	ml	NOUN
admet-782	69	60	)	)	PUNCT
admet-782	69	61	.	.	PUNCT
admet-782	70	1	stability	stability	NOUN
admet-782	70	2	(	(	PUNCT
admet-782	70	3	auto	auto	NOUN
admet-782	70	4	-	-	PUNCT
admet-782	70	5	sampler	sampler	ADJ
admet-782	70	6	,	,	PUNCT
admet-782	70	7	bench	bench	NOUN
admet-782	70	8	-	-	PUNCT
admet-782	70	9	top	top	NOUN
admet-782	70	10	,	,	PUNCT
admet-782	70	11	freezethaw	freezethaw	NOUN
admet-782	70	12	and	and	CCONJ
admet-782	70	13	long	long	ADJ
admet-782	70	14	-	-	PUNCT
admet-782	70	15	term	term	NOUN
admet-782	70	16	)	)	PUNCT
admet-782	70	17	studies	study	NOUN
admet-782	70	18	,	,	PUNCT
admet-782	70	19	dilution	dilution	NOUN
admet-782	70	20	effect	effect	NOUN
admet-782	70	21	and	and	CCONJ
admet-782	70	22	incurred	incur	VERB
admet-782	70	23	sample	sample	NOUN
admet-782	70	24	reanalysis	reanalysis	NOUN
admet-782	70	25	(	(	PUNCT
admet-782	70	26	isr	isr	NOUN
admet-782	70	27	)	)	PUNCT
admet-782	70	28	were	be	AUX
admet-782	70	29	also	also	ADV
admet-782	70	30	evaluated	evaluate	VERB
admet-782	70	31	as	as	ADP
admet-782	70	32	per	per	ADP
admet-782	70	33	regulatory	regulatory	ADJ
admet-782	70	34	guideline	guideline	NOUN
admet-782	70	35	requirement	requirement	NOUN
admet-782	71	1	[	[	X
admet-782	71	2	12	12	NUM
admet-782	71	3	]	]	PUNCT
admet-782	71	4	.	.	PUNCT
admet-782	72	1	pharmacokinetic	pharmacokinetic	ADJ
admet-782	72	2	study	study	NOUN
admet-782	72	3	in	in	ADP
admet-782	72	4	mice	mice	NOUN
admet-782	72	5	twelve	twelve	NUM
admet-782	72	6	male	male	ADJ
admet-782	72	7	balb	balb	NOUN
admet-782	72	8	/	/	SYM
admet-782	72	9	c	c	NOUN
admet-782	72	10	mice	mouse	NOUN
admet-782	72	11	(	(	PUNCT
admet-782	72	12	weight	weight	NOUN
admet-782	72	13	range	range	NOUN
admet-782	72	14	:	:	PUNCT
admet-782	72	15	26	26	NUM
admet-782	72	16	-	-	SYM
admet-782	72	17	28	28	NUM
admet-782	72	18	g	g	NOUN
admet-782	72	19	)	)	PUNCT
admet-782	72	20	were	be	AUX
admet-782	72	21	procured	procure	VERB
admet-782	72	22	from	from	ADP
admet-782	72	23	vivo	vivo	ADJ
admet-782	72	24	biotech	biotech	NOUN
admet-782	72	25	,	,	PUNCT
admet-782	72	26	hyderabad	hyderabad	PROPN
admet-782	72	27	,	,	PUNCT
admet-782	72	28	india	india	PROPN
admet-782	72	29	.	.	PUNCT
admet-782	73	1	animal	animal	NOUN
admet-782	73	2	study	study	NOUN
admet-782	73	3	protocol	protocol	NOUN
admet-782	73	4	used	use	VERB
admet-782	73	5	in	in	ADP
admet-782	73	6	this	this	DET
admet-782	73	7	study	study	NOUN
admet-782	73	8	was	be	AUX
admet-782	73	9	approved	approve	VERB
admet-782	73	10	by	by	ADP
admet-782	73	11	the	the	DET
admet-782	73	12	institutional	institutional	ADJ
admet-782	73	13	animal	animal	NOUN
admet-782	73	14	ethics	ethic	NOUN
admet-782	73	15	committee	committee	NOUN
admet-782	73	16	,	,	PUNCT
admet-782	73	17	jubilant	jubilant	ADJ
admet-782	73	18	biosys	biosys	NOUN
admet-782	73	19	(	(	PUNCT
admet-782	73	20	iaec	iaec	NOUN
admet-782	73	21	/	/	SYM
admet-782	73	22	jdc/2019/188r	jdc/2019/188r	PROPN
admet-782	73	23	)	)	PUNCT
admet-782	73	24	.	.	PUNCT
admet-782	74	1	mice	mouse	NOUN
admet-782	74	2	were	be	AUX
admet-782	74	3	housed	house	VERB
admet-782	74	4	for	for	ADP
admet-782	74	5	a	a	DET
admet-782	74	6	period	period	NOUN
admet-782	74	7	of	of	ADP
admet-782	74	8	seven	seven	NUM
admet-782	74	9	days	day	NOUN
admet-782	74	10	having	have	VERB
admet-782	74	11	free	free	ADJ
admet-782	74	12	access	access	NOUN
admet-782	74	13	to	to	ADP
admet-782	74	14	feed	feed	NOUN
admet-782	74	15	and	and	CCONJ
admet-782	74	16	water	water	NOUN
admet-782	74	17	before	before	ADP
admet-782	74	18	the	the	DET
admet-782	74	19	pharmacokinetic	pharmacokinetic	ADJ
admet-782	74	20	study	study	NOUN
admet-782	74	21	.	.	PUNCT
admet-782	75	1	mice	mouse	NOUN
admet-782	75	2	received	receive	VERB
admet-782	75	3	copanlisib	copanlisib	PROPN
admet-782	75	4	intravenously	intravenously	ADV
admet-782	75	5	[	[	X
admet-782	75	6	2	2	NUM
admet-782	75	7	%	%	NOUN
admet-782	75	8	0.1	0.1	NUM
admet-782	75	9	n	n	PRON
admet-782	75	10	hcl	hcl	PROPN
admet-782	75	11	,	,	PUNCT
admet-782	75	12	10	10	NUM
admet-782	75	13	%	%	NOUN
admet-782	75	14	dmso	dmso	NOUN
admet-782	75	15	,	,	PUNCT
admet-782	75	16	10	10	NUM
admet-782	75	17	%	%	NOUN
admet-782	75	18	solutol	solutol	NOUN
admet-782	75	19	:	:	PUNCT
admet-782	75	20	absolute	absolute	ADJ
admet-782	75	21	alcohol	alcohol	NOUN
admet-782	75	22	(	(	PUNCT
admet-782	75	23	1:1	1:1	NUM
admet-782	75	24	,	,	PUNCT
admet-782	75	25	v	v	NOUN
admet-782	75	26	/	/	SYM
admet-782	75	27	v	v	NOUN
admet-782	75	28	)	)	PUNCT
admet-782	75	29	and	and	CCONJ
admet-782	75	30	78	78	NUM
admet-782	75	31	%	%	NOUN
admet-782	75	32	normal	normal	ADJ
admet-782	75	33	saline	saline	NOUN
admet-782	75	34	;	;	PUNCT
admet-782	75	35	strength	strength	NOUN
admet-782	75	36	:	:	PUNCT
admet-782	75	37	0.5	0.5	NUM
admet-782	75	38	mg	mg	NUM
admet-782	75	39	/	/	SYM
admet-782	75	40	ml	ml	PROPN
admet-782	75	41	;	;	PUNCT
admet-782	75	42	dose	dose	NOUN
admet-782	75	43	volume	volume	NOUN
admet-782	75	44	:	:	PUNCT
admet-782	75	45	10	10	NUM
admet-782	75	46	ml	ml	NOUN
admet-782	75	47	/	/	SYM
admet-782	75	48	kg	kg	X
admet-782	75	49	]	]	X
admet-782	75	50	at	at	ADP
admet-782	75	51	5.0	5.0	NUM
admet-782	75	52	mg	mg	NOUN
admet-782	75	53	/	/	SYM
admet-782	75	54	kg	kg	PROPN
admet-782	75	55	as	as	ADP
admet-782	75	56	a	a	DET
admet-782	75	57	bolus	bolus	ADJ
admet-782	75	58	dose	dose	NOUN
admet-782	75	59	.	.	PUNCT
admet-782	76	1	blood	blood	NOUN
admet-782	76	2	samples	sample	NOUN
admet-782	76	3	(	(	PUNCT
admet-782	76	4	100	100	NUM
admet-782	76	5	µl	µl	NOUN
admet-782	76	6	)	)	PUNCT
admet-782	76	7	were	be	AUX
admet-782	76	8	collected	collect	VERB
admet-782	76	9	at	at	ADP
admet-782	76	10	pre	pre	ADJ
admet-782	76	11	-	-	ADJ
admet-782	76	12	determined	determined	ADJ
admet-782	76	13	time	time	NOUN
admet-782	76	14	points	point	NOUN
admet-782	76	15	(	(	PUNCT
admet-782	76	16	0.12	0.12	NUM
admet-782	76	17	,	,	PUNCT
admet-782	76	18	0.25	0.25	NUM
admet-782	76	19	,	,	PUNCT
admet-782	76	20	0.5	0.5	NUM
admet-782	76	21	,	,	PUNCT
admet-782	76	22	1	1	NUM
admet-782	76	23	,	,	PUNCT
admet-782	76	24	2	2	NUM
admet-782	76	25	,	,	PUNCT
admet-782	76	26	4	4	NUM
admet-782	76	27	,	,	PUNCT
admet-782	76	28	8	8	NUM
admet-782	76	29	and	and	CCONJ
admet-782	76	30	24	24	NUM
admet-782	76	31	h	h	NOUN
admet-782	76	32	)	)	PUNCT
admet-782	76	33	through	through	ADP
admet-782	76	34	retro	retro	ADJ
admet-782	76	35	-	-	PUNCT
admet-782	76	36	orbital	orbital	ADJ
admet-782	76	37	plexus	plexus	NOUN
admet-782	76	38	(	(	PUNCT
admet-782	76	39	using	use	VERB
admet-782	76	40	micropipettes	micropipette	NOUN
admet-782	76	41	,	,	PUNCT
admet-782	76	42	drummond	drummond	PROPN
admet-782	76	43	scientific	scientific	PROPN
admet-782	76	44	,	,	PUNCT
admet-782	76	45	pa	pa	PROPN
admet-782	76	46	,	,	PUNCT
admet-782	76	47	usa	usa	PROPN
admet-782	76	48	;	;	PUNCT
admet-782	76	49	catalogue	catalogue	NOUN
admet-782	76	50	number	number	NOUN
admet-782	76	51	:	:	PUNCT
admet-782	76	52	1	1	NUM
admet-782	76	53	-	-	PUNCT
admet-782	76	54	000	000	NUM
admet-782	76	55	-	-	PUNCT
admet-782	76	56	0500	0500	NUM
admet-782	76	57	)	)	PUNCT
admet-782	76	58	into	into	ADP
admet-782	76	59	polypropylene	polypropylene	NOUN
admet-782	76	60	tubes	tube	NOUN
admet-782	76	61	(	(	PUNCT
admet-782	76	62	having	have	VERB
admet-782	76	63	k2.edta	k2.edta	NOUN
admet-782	76	64	as	as	ADP
admet-782	76	65	an	an	DET
admet-782	76	66	anti	anti	ADJ
admet-782	76	67	-	-	ADJ
admet-782	76	68	coagulant	coagulant	ADJ
admet-782	76	69	)	)	PUNCT
admet-782	76	70	.	.	PUNCT
admet-782	77	1	sparse	sparse	ADJ
admet-782	77	2	sampling	sample	VERB
admet-782	77	3	technique	technique	NOUN
admet-782	77	4	(	(	PUNCT
admet-782	77	5	three	three	NUM
admet-782	77	6	mice	mouse	NOUN
admet-782	77	7	per	per	ADP
admet-782	77	8	time	time	NOUN
admet-782	77	9	point	point	NOUN
admet-782	77	10	)	)	PUNCT
admet-782	77	11	was	be	AUX
admet-782	77	12	adopted	adopt	VERB
admet-782	77	13	during	during	ADP
admet-782	77	14	blood	blood	NOUN
admet-782	77	15	collection	collection	NOUN
admet-782	77	16	so	so	SCONJ
admet-782	77	17	that	that	SCONJ
admet-782	77	18	blood	blood	NOUN
admet-782	77	19	loss	loss	NOUN
admet-782	77	20	from	from	ADP
admet-782	77	21	each	each	DET
admet-782	77	22	mouse	mouse	NOUN
admet-782	77	23	was	be	AUX
admet-782	77	24	kept	keep	VERB
admet-782	77	25	less	less	ADJ
admet-782	77	26	than	than	ADP
admet-782	77	27	10	10	NUM
admet-782	77	28	%	%	NOUN
admet-782	77	29	of	of	ADP
admet-782	77	30	total	total	ADJ
admet-782	77	31	blood	blood	NOUN
admet-782	77	32	volume	volume	NOUN
admet-782	77	33	.	.	PUNCT
admet-782	78	1	plasma	plasma	NOUN
admet-782	78	2	was	be	AUX
admet-782	78	3	harvested	harvest	VERB
admet-782	78	4	by	by	ADP
admet-782	78	5	centrifuging	centrifuge	VERB
admet-782	78	6	the	the	DET
admet-782	78	7	blood	blood	NOUN
admet-782	78	8	using	use	VERB
admet-782	78	9	biofuge	biofuge	NOUN
admet-782	78	10	(	(	PUNCT
admet-782	78	11	hereaus	hereaus	PROPN
admet-782	78	12	,	,	PUNCT
admet-782	78	13	germany	germany	PROPN
admet-782	78	14	)	)	PUNCT
admet-782	78	15	at	at	ADP
admet-782	78	16	1760	1760	NUM
admet-782	78	17	g	g	NOUN
admet-782	78	18	for	for	ADP
admet-782	78	19	5	5	NUM
admet-782	78	20	min	min	NOUN
admet-782	78	21	and	and	CCONJ
admet-782	78	22	stored	store	VERB
admet-782	78	23	frozen	frozen	ADJ
admet-782	78	24	at	at	ADP
admet-782	78	25	-80±10	-80±10	PROPN
admet-782	78	26	°	°	PROPN
admet-782	78	27	c	c	NOUN
admet-782	78	28	until	until	ADP
admet-782	78	29	analysis	analysis	NOUN
admet-782	78	30	.	.	PUNCT
admet-782	79	1	mice	mouse	NOUN
admet-782	79	2	were	be	AUX
admet-782	79	3	allowed	allow	VERB
admet-782	79	4	to	to	PART
admet-782	79	5	access	access	VERB
admet-782	79	6	feed	feed	NOUN
admet-782	79	7	2	2	NUM
admet-782	79	8	h	h	NOUN
admet-782	79	9	post	post	ADJ
admet-782	79	10	-	-	ADJ
admet-782	79	11	dosing	dosing	ADJ
admet-782	79	12	.	.	PUNCT
admet-782	80	1	pharmacokinetic	pharmacokinetic	ADJ
admet-782	80	2	analysis	analysis	NOUN
admet-782	80	3	pharmacokinetic	pharmacokinetic	ADJ
admet-782	80	4	parameters	parameter	NOUN
admet-782	80	5	were	be	AUX
admet-782	80	6	calculated	calculate	VERB
admet-782	80	7	by	by	ADP
admet-782	80	8	a	a	DET
admet-782	80	9	non	non	ADJ
admet-782	80	10	-	-	ADJ
admet-782	80	11	compartmental	compartmental	ADJ
admet-782	80	12	method	method	NOUN
admet-782	80	13	using	use	VERB
admet-782	80	14	phoenix	phoenix	PROPN
admet-782	80	15	winnonlin	winnonlin	PROPN
admet-782	80	16	8.1	8.1	NUM
admet-782	80	17	software	software	NOUN
admet-782	80	18	(	(	PUNCT
admet-782	80	19	pharsight	pharsight	NOUN
admet-782	80	20	,	,	PUNCT
admet-782	80	21	mountain	mountain	NOUN
admet-782	80	22	view	view	NOUN
admet-782	80	23	,	,	PUNCT
admet-782	80	24	ca	ca	PROPN
admet-782	80	25	,	,	PUNCT
admet-782	80	26	usa	usa	PROPN
admet-782	80	27	)	)	PUNCT
admet-782	80	28	.	.	PUNCT
admet-782	81	1	key	key	ADJ
admet-782	81	2	pharmacokinetic	pharmacokinetic	ADJ
admet-782	81	3	parameters	parameter	NOUN
admet-782	81	4	like	like	ADP
admet-782	81	5	extrapolated	extrapolated	ADJ
admet-782	81	6	plasma	plasma	NOUN
admet-782	81	7	drug	drug	NOUN
admet-782	81	8	concentration	concentration	NOUN
admet-782	81	9	at	at	ADP
admet-782	81	10	time	time	NOUN
admet-782	81	11	zero	zero	NUM
admet-782	81	12	following	follow	VERB
admet-782	81	13	intravenous	intravenous	ADJ
admet-782	81	14	bolus	bolus	ADJ
admet-782	81	15	injection	injection	NOUN
admet-782	81	16	(	(	PUNCT
admet-782	81	17	c0	c0	NOUN
admet-782	81	18	)	)	PUNCT
admet-782	81	19	,	,	PUNCT
admet-782	81	20	area	area	NOUN
admet-782	81	21	under	under	ADP
admet-782	81	22	the	the	DET
admet-782	81	23	curve	curve	NOUN
admet-782	81	24	from	from	ADP
admet-782	81	25	time	time	NOUN
admet-782	81	26	zero	zero	NUM
admet-782	81	27	to	to	ADP
admet-782	81	28	infinity	infinity	NOUN
admet-782	81	29	(	(	PUNCT
admet-782	81	30	auc0-	auc0-	NOUN
admet-782	81	31	)	)	PUNCT
admet-782	81	32	,	,	PUNCT
admet-782	81	33	volume	volume	NOUN
admet-782	81	34	of	of	ADP
admet-782	81	35	distribution	distribution	NOUN
admet-782	81	36	(	(	PUNCT
admet-782	81	37	vd	vd	NOUN
admet-782	81	38	)	)	PUNCT
admet-782	81	39	,	,	PUNCT
admet-782	81	40	total	total	ADJ
admet-782	81	41	body	body	NOUN
admet-782	81	42	clearance	clearance	NOUN
admet-782	81	43	(	(	PUNCT
admet-782	81	44	cl	cl	NOUN
admet-782	81	45	)	)	PUNCT
admet-782	81	46	and	and	CCONJ
admet-782	81	47	halflife	halflife	NOUN
admet-782	81	48	(	(	PUNCT
admet-782	81	49	t½	t½	NOUN
admet-782	81	50	)	)	PUNCT
admet-782	81	51	were	be	AUX
admet-782	81	52	determined	determine	VERB
admet-782	81	53	for	for	ADP
admet-782	81	54	copanlisib	copanlisib	PROPN
admet-782	81	55	.	.	PUNCT
admet-782	82	1	admet	admet	PROPN
admet-782	82	2	&	&	CCONJ
admet-782	82	3	dmpk	dmpk	PROPN
admet-782	82	4	8(1	8(1	NOUN
admet-782	82	5	)	)	PUNCT
admet-782	82	6	(	(	PUNCT
admet-782	82	7	2020	2020	NUM
admet-782	82	8	)	)	PUNCT
admet-782	82	9	113	113	NUM
admet-782	82	10	-	-	SYM
admet-782	82	11	121	121	NUM
admet-782	82	12	copanlisib	copanlisib	NOUN
admet-782	82	13	quantification	quantification	NOUN
admet-782	82	14	by	by	ADP
admet-782	82	15	hplc	hplc	NOUN
admet-782	82	16	in	in	ADP
admet-782	82	17	mice	mice	NOUN
admet-782	82	18	plasma	plasma	NOUN
admet-782	82	19	doi	doi	PROPN
admet-782	82	20	:	:	PUNCT
admet-782	82	21	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	82	22	117	117	NUM
admet-782	82	23	results	result	NOUN
admet-782	82	24	and	and	CCONJ
admet-782	82	25	discussion	discussion	NOUN
admet-782	82	26	method	method	NOUN
admet-782	82	27	development	development	NOUN
admet-782	82	28	and	and	CCONJ
admet-782	82	29	optimization	optimization	NOUN
admet-782	82	30	several	several	ADJ
admet-782	82	31	trials	trial	NOUN
admet-782	82	32	were	be	AUX
admet-782	82	33	taken	take	VERB
admet-782	82	34	with	with	ADP
admet-782	82	35	various	various	ADJ
admet-782	82	36	columns	column	NOUN
admet-782	82	37	,	,	PUNCT
admet-782	82	38	mobile	mobile	ADJ
admet-782	82	39	phase	phase	NOUN
admet-782	82	40	compositions	composition	NOUN
admet-782	82	41	to	to	PART
admet-782	82	42	select	select	VERB
admet-782	82	43	the	the	DET
admet-782	82	44	chromatographic	chromatographic	ADJ
admet-782	82	45	conditions	condition	NOUN
admet-782	82	46	,	,	PUNCT
admet-782	82	47	which	which	PRON
admet-782	82	48	will	will	AUX
admet-782	82	49	give	give	VERB
admet-782	82	50	a	a	DET
admet-782	82	51	good	good	ADJ
admet-782	82	52	resolution	resolution	NOUN
admet-782	82	53	of	of	ADP
admet-782	82	54	copanlisib	copanlisib	PROPN
admet-782	82	55	and	and	CCONJ
admet-782	82	56	the	the	PRON
admet-782	82	57	is	be	AUX
admet-782	82	58	from	from	ADP
admet-782	82	59	the	the	DET
admet-782	82	60	endogenous	endogenous	ADJ
admet-782	82	61	matrix	matrix	NOUN
admet-782	82	62	substances	substance	NOUN
admet-782	82	63	within	within	ADP
admet-782	82	64	a	a	DET
admet-782	82	65	suitable	suitable	ADJ
admet-782	82	66	run	run	NOUN
admet-782	82	67	time	time	NOUN
admet-782	82	68	.	.	PUNCT
admet-782	83	1	several	several	ADJ
admet-782	83	2	mobile	mobile	ADJ
admet-782	83	3	phases	phase	NOUN
admet-782	83	4	were	be	AUX
admet-782	83	5	tried	try	VERB
admet-782	83	6	by	by	ADP
admet-782	83	7	changing	change	VERB
admet-782	83	8	the	the	DET
admet-782	83	9	combination	combination	NOUN
admet-782	83	10	of	of	ADP
admet-782	83	11	different	different	ADJ
admet-782	83	12	organic	organic	ADJ
admet-782	83	13	solvents	solvent	NOUN
admet-782	83	14	(	(	PUNCT
admet-782	83	15	acetonitrile	acetonitrile	NOUN
admet-782	83	16	and	and	CCONJ
admet-782	83	17	methanol	methanol	NOUN
admet-782	83	18	)	)	PUNCT
admet-782	83	19	and	and	CCONJ
admet-782	83	20	buffers	buffer	NOUN
admet-782	83	21	(	(	PUNCT
admet-782	83	22	eg	eg	NOUN
admet-782	83	23	:	:	PUNCT
admet-782	83	24	formic	formic	ADJ
admet-782	83	25	acid	acid	NOUN
admet-782	83	26	,	,	PUNCT
admet-782	83	27	ammonium	ammonium	NOUN
admet-782	83	28	acetate	acetate	NOUN
admet-782	83	29	,	,	PUNCT
admet-782	83	30	phosphate	phosphate	NOUN
admet-782	83	31	buffer	buffer	NOUN
admet-782	83	32	etc	etc	X
admet-782	83	33	.	.	PUNCT
admet-782	83	34	)	)	PUNCT
admet-782	83	35	with	with	ADP
admet-782	83	36	altered	altered	ADJ
admet-782	83	37	flow	flow	NOUN
admet-782	83	38	-	-	PUNCT
admet-782	83	39	rates	rate	NOUN
admet-782	83	40	(	(	PUNCT
admet-782	83	41	in	in	ADP
admet-782	83	42	the	the	DET
admet-782	83	43	range	range	NOUN
admet-782	83	44	of	of	ADP
admet-782	83	45	0.60	0.60	NUM
admet-782	83	46	-	-	SYM
admet-782	83	47	1.20	1.20	NUM
admet-782	83	48	ml	ml	NOUN
admet-782	83	49	/	/	SYM
admet-782	83	50	min	min	NOUN
admet-782	83	51	)	)	PUNCT
admet-782	83	52	.	.	PUNCT
admet-782	84	1	to	to	PART
admet-782	84	2	choose	choose	VERB
admet-782	84	3	a	a	DET
admet-782	84	4	stationary	stationary	ADJ
admet-782	84	5	phase	phase	NOUN
admet-782	84	6	a	a	DET
admet-782	84	7	variety	variety	NOUN
admet-782	84	8	of	of	ADP
admet-782	84	9	columns	column	NOUN
admet-782	84	10	namely	namely	ADV
admet-782	84	11	x	x	ADJ
admet-782	84	12	-	-	NOUN
admet-782	84	13	terra	terra	ADJ
admet-782	84	14	phenyl	phenyl	NOUN
admet-782	84	15	,	,	PUNCT
admet-782	84	16	atlantis	atlantis	PROPN
admet-782	84	17	,	,	PUNCT
admet-782	84	18	hypersil	hypersil	NOUN
admet-782	84	19	gold	gold	NOUN
admet-782	84	20	c18	c18	NOUN
admet-782	84	21	were	be	AUX
admet-782	84	22	evaluated	evaluate	VERB
admet-782	84	23	.	.	PUNCT
admet-782	85	1	our	our	PRON
admet-782	85	2	trials	trial	NOUN
admet-782	85	3	revealed	reveal	VERB
admet-782	85	4	that	that	SCONJ
admet-782	85	5	mobile	mobile	ADJ
admet-782	85	6	phase	phase	NOUN
admet-782	85	7	comprising	comprise	VERB
admet-782	85	8	10	10	NUM
admet-782	85	9	mm	mm	NOUN
admet-782	85	10	ammonium	ammonium	NOUN
admet-782	85	11	formate	formate	NOUN
admet-782	85	12	(	(	PUNCT
admet-782	85	13	ph	ph	PROPN
admet-782	85	14	4.0):acetonitrile	4.0):acetonitrile	PROPN
admet-782	85	15	delivered	deliver	VERB
admet-782	85	16	in	in	ADP
admet-782	85	17	a	a	DET
admet-782	85	18	gradient	gradient	ADJ
admet-782	85	19	program	program	NOUN
admet-782	85	20	at	at	ADP
admet-782	85	21	a	a	DET
admet-782	85	22	flow	flow	NOUN
admet-782	85	23	-	-	PUNCT
admet-782	85	24	rate	rate	NOUN
admet-782	85	25	of	of	ADP
admet-782	85	26	0.8	0.8	NUM
admet-782	85	27	ml	ml	NOUN
admet-782	85	28	/	/	SYM
admet-782	85	29	min	min	NOUN
admet-782	85	30	on	on	ADP
admet-782	85	31	hypersil	hypersil	NOUN
admet-782	85	32	gold	gold	NOUN
admet-782	85	33	c18	c18	NOUN
admet-782	85	34	column	column	NOUN
admet-782	85	35	gave	give	VERB
admet-782	85	36	a	a	DET
admet-782	85	37	stable	stable	ADJ
admet-782	85	38	base	base	NOUN
admet-782	85	39	line	line	NOUN
admet-782	85	40	with	with	ADP
admet-782	85	41	good	good	ADJ
admet-782	85	42	resolution	resolution	NOUN
admet-782	85	43	between	between	ADP
admet-782	85	44	copanlisib	copanlisib	PROPN
admet-782	85	45	and	and	CCONJ
admet-782	85	46	the	the	PRON
admet-782	85	47	is	be	AUX
admet-782	85	48	with	with	ADP
admet-782	85	49	a	a	DET
admet-782	85	50	total	total	ADJ
admet-782	85	51	run	run	NOUN
admet-782	85	52	time	time	NOUN
admet-782	85	53	of	of	ADP
admet-782	85	54	10	10	NUM
admet-782	85	55	min	min	NOUN
admet-782	85	56	with	with	ADP
admet-782	85	57	no	no	DET
admet-782	85	58	interference	interference	NOUN
admet-782	85	59	of	of	ADP
admet-782	85	60	endogenous	endogenous	ADJ
admet-782	85	61	plasma	plasma	NOUN
admet-782	85	62	peaks	peak	NOUN
admet-782	85	63	.	.	PUNCT
admet-782	86	1	the	the	DET
admet-782	86	2	uv	uv	NOUN
admet-782	86	3	detector	detector	NOUN
admet-782	86	4	was	be	AUX
admet-782	86	5	set	set	VERB
admet-782	86	6	at	at	ADP
admet-782	86	7	λmax	λmax	NOUN
admet-782	86	8	310	310	NUM
admet-782	86	9	nm	nm	NOUN
admet-782	86	10	.	.	PUNCT
admet-782	87	1	for	for	ADP
admet-782	87	2	the	the	DET
admet-782	87	3	optimized	optimize	VERB
admet-782	87	4	conditions	condition	NOUN
admet-782	87	5	,	,	PUNCT
admet-782	87	6	enasidenib	enasidenib	NOUN
admet-782	87	7	was	be	AUX
admet-782	87	8	found	find	VERB
admet-782	87	9	to	to	PART
admet-782	87	10	be	be	AUX
admet-782	87	11	a	a	DET
admet-782	87	12	suitable	suitable	ADJ
admet-782	87	13	internal	internal	ADJ
admet-782	87	14	standard	standard	NOUN
admet-782	87	15	as	as	SCONJ
admet-782	87	16	it	it	PRON
admet-782	87	17	exhibited	exhibit	VERB
admet-782	87	18	good	good	ADJ
admet-782	87	19	resolution	resolution	NOUN
admet-782	87	20	,	,	PUNCT
admet-782	87	21	retention	retention	NOUN
admet-782	87	22	time	time	NOUN
admet-782	87	23	and	and	CCONJ
admet-782	87	24	uv	uv	NOUN
admet-782	87	25	absorbance	absorbance	NOUN
admet-782	87	26	intensity	intensity	NOUN
admet-782	87	27	(	(	PUNCT
admet-782	87	28	uv	uv	NOUN
admet-782	87	29	λmax	λmax	NOUN
admet-782	87	30	287	287	NUM
admet-782	87	31	nm	nm	NOUN
admet-782	87	32	)	)	PUNCT
admet-782	87	33	at	at	ADP
admet-782	87	34	the	the	DET
admet-782	87	35	same	same	ADJ
admet-782	87	36	wave	wave	NOUN
admet-782	87	37	length	length	NOUN
admet-782	87	38	of	of	ADP
admet-782	87	39	copanlisib	copanlisib	PROPN
admet-782	87	40	.	.	PUNCT
admet-782	88	1	method	method	PROPN
admet-782	88	2	validation	validation	NOUN
admet-782	88	3	with	with	ADP
admet-782	88	4	protein	protein	NOUN
admet-782	88	5	precipitation	precipitation	NOUN
admet-782	88	6	technique	technique	NOUN
admet-782	88	7	the	the	DET
admet-782	88	8	recovery	recovery	NOUN
admet-782	88	9	of	of	ADP
admet-782	88	10	copanlisib	copanlisib	PROPN
admet-782	88	11	and	and	CCONJ
admet-782	88	12	is	be	AUX
admet-782	88	13	was	be	AUX
admet-782	88	14	very	very	ADV
admet-782	88	15	poor	poor	ADJ
admet-782	88	16	(	(	PUNCT
admet-782	88	17	<	<	X
admet-782	88	18	40	40	NUM
admet-782	88	19	%	%	NOUN
admet-782	88	20	)	)	PUNCT
admet-782	88	21	.	.	PUNCT
admet-782	89	1	liquidliquid	liquidliquid	ADJ
admet-782	89	2	extraction	extraction	NOUN
admet-782	89	3	with	with	ADP
admet-782	89	4	ethyl	ethyl	PROPN
admet-782	89	5	acetate	acetate	PROPN
admet-782	89	6	gave	give	VERB
admet-782	89	7	best	good	ADJ
admet-782	89	8	results	result	NOUN
admet-782	89	9	in	in	ADP
admet-782	89	10	terms	term	NOUN
admet-782	89	11	of	of	ADP
admet-782	89	12	extraction	extraction	NOUN
admet-782	89	13	recovery	recovery	NOUN
admet-782	89	14	,	,	PUNCT
admet-782	89	15	reproducibility	reproducibility	NOUN
admet-782	89	16	and	and	CCONJ
admet-782	89	17	cleaner	clean	ADJ
admet-782	89	18	samples	sample	NOUN
admet-782	89	19	.	.	PUNCT
admet-782	90	1	the	the	DET
admet-782	90	2	mean	mean	ADJ
admet-782	90	3	±	±	PROPN
admet-782	90	4	s.d	s.d	PROPN
admet-782	90	5	recovery	recovery	NOUN
admet-782	90	6	of	of	ADP
admet-782	90	7	copanlisib	copanlisib	PROPN
admet-782	90	8	at	at	ADP
admet-782	90	9	lqc	lqc	ADV
admet-782	90	10	and	and	CCONJ
admet-782	90	11	hqc	hqc	PROPN
admet-782	90	12	was	be	AUX
admet-782	90	13	83.8	83.8	NUM
admet-782	90	14	±	±	NUM
admet-782	90	15	4.51	4.51	NUM
admet-782	90	16	and	and	CCONJ
admet-782	90	17	83.9	83.9	NUM
admet-782	90	18	±	±	NUM
admet-782	90	19	1.17	1.17	NUM
admet-782	90	20	%	%	NOUN
admet-782	90	21	,	,	PUNCT
admet-782	90	22	respectively	respectively	ADV
admet-782	90	23	.	.	PUNCT
admet-782	91	1	the	the	DET
admet-782	91	2	recovery	recovery	NOUN
admet-782	91	3	of	of	ADP
admet-782	91	4	the	the	PRON
admet-782	91	5	is	be	AUX
admet-782	91	6	was	be	AUX
admet-782	91	7	99.5	99.5	NUM
admet-782	91	8	±	±	NUM
admet-782	91	9	1.33	1.33	NUM
admet-782	91	10	%	%	NOUN
admet-782	91	11	.	.	PUNCT
admet-782	92	1	as	as	SCONJ
admet-782	92	2	shown	show	VERB
admet-782	92	3	in	in	ADP
admet-782	92	4	fig	fig	NOUN
admet-782	92	5	.	.	PUNCT
admet-782	93	1	2	2	NUM
admet-782	93	2	,	,	PUNCT
admet-782	93	3	both	both	DET
admet-782	93	4	copanlisib	copanlisib	PROPN
admet-782	93	5	and	and	CCONJ
admet-782	93	6	the	the	PRON
admet-782	93	7	is	be	AUX
admet-782	93	8	peaks	peak	NOUN
admet-782	93	9	were	be	AUX
admet-782	93	10	well	well	ADV
admet-782	93	11	resolved	resolve	VERB
admet-782	93	12	and	and	CCONJ
admet-782	93	13	no	no	DET
admet-782	93	14	interference	interference	NOUN
admet-782	93	15	at	at	ADP
admet-782	93	16	the	the	DET
admet-782	93	17	retention	retention	NOUN
admet-782	93	18	times	time	NOUN
admet-782	93	19	of	of	ADP
admet-782	93	20	copanlisib	copanlisib	PROPN
admet-782	93	21	and	and	CCONJ
admet-782	93	22	the	the	PRON
admet-782	93	23	is	be	AUX
admet-782	93	24	from	from	ADP
admet-782	93	25	the	the	DET
admet-782	93	26	endogenous	endogenous	ADJ
admet-782	93	27	components	component	NOUN
admet-782	93	28	of	of	ADP
admet-782	93	29	mice	mouse	NOUN
admet-782	93	30	.	.	PUNCT
admet-782	94	1	the	the	DET
admet-782	94	2	retention	retention	NOUN
admet-782	94	3	time	time	NOUN
admet-782	94	4	of	of	ADP
admet-782	94	5	copanlisib	copanlisib	PROPN
admet-782	94	6	and	and	CCONJ
admet-782	94	7	the	the	PRON
admet-782	94	8	is	be	AUX
admet-782	94	9	was	be	AUX
admet-782	94	10	6.60	6.60	NUM
admet-782	94	11	and	and	CCONJ
admet-782	94	12	7.80	7.80	NUM
admet-782	94	13	min	min	NOUN
admet-782	94	14	,	,	PUNCT
admet-782	94	15	respectively	respectively	ADV
admet-782	94	16	.	.	PUNCT
admet-782	95	1	the	the	DET
admet-782	95	2	calibration	calibration	NOUN
admet-782	95	3	curves	curve	NOUN
admet-782	95	4	(	(	PUNCT
admet-782	95	5	n=4	n=4	NOUN
admet-782	95	6	)	)	PUNCT
admet-782	95	7	for	for	ADP
admet-782	95	8	copanlisib	copanlisib	PROPN
admet-782	95	9	were	be	AUX
admet-782	95	10	observed	observe	VERB
admet-782	95	11	to	to	PART
admet-782	95	12	be	be	AUX
admet-782	95	13	linear	linear	ADJ
admet-782	95	14	in	in	ADP
admet-782	95	15	the	the	DET
admet-782	95	16	range	range	NOUN
admet-782	95	17	of	of	ADP
admet-782	95	18	50	50	NUM
admet-782	95	19	-	-	SYM
admet-782	95	20	5000	5000	NUM
admet-782	95	21	ng	ng	PROPN
admet-782	95	22	/	/	SYM
admet-782	95	23	ml	ml	PROPN
admet-782	95	24	.	.	PUNCT
admet-782	96	1	a	a	DET
admet-782	96	2	representative	representative	ADJ
admet-782	96	3	equation	equation	NOUN
admet-782	96	4	for	for	ADP
admet-782	96	5	the	the	DET
admet-782	96	6	calibration	calibration	NOUN
admet-782	96	7	curves	curve	NOUN
admet-782	96	8	is	be	AUX
admet-782	96	9	as	as	SCONJ
admet-782	96	10	follows	follow	VERB
admet-782	96	11	:	:	PUNCT
admet-782	97	1	y	y	NOUN
admet-782	97	2	=	=	PUNCT
admet-782	97	3	0.0005	0.0005	NUM
admet-782	97	4	x	x	PUNCT
admet-782	98	1	+	+	NUM
admet-782	98	2	0.003	0.003	NUM
admet-782	98	3	.	.	PUNCT
admet-782	99	1	a	a	DET
admet-782	99	2	regression	regression	NOUN
admet-782	99	3	equation	equation	NOUN
admet-782	99	4	with	with	ADP
admet-782	99	5	a	a	DET
admet-782	99	6	weighting	weighting	NOUN
admet-782	99	7	factor	factor	NOUN
admet-782	99	8	of	of	ADP
admet-782	99	9	1	1	NUM
admet-782	99	10	/	/	SYM
admet-782	99	11	x2	x2	NOUN
admet-782	99	12	of	of	ADP
admet-782	99	13	each	each	DET
admet-782	99	14	drug	drug	NOUN
admet-782	99	15	to	to	ADP
admet-782	99	16	the	the	PRON
admet-782	99	17	is	be	AUX
admet-782	99	18	concentration	concentration	NOUN
admet-782	99	19	was	be	AUX
admet-782	99	20	found	find	VERB
admet-782	99	21	to	to	PART
admet-782	99	22	produce	produce	VERB
admet-782	99	23	the	the	DET
admet-782	99	24	best	good	ADJ
admet-782	99	25	fit	fit	NOUN
admet-782	99	26	for	for	ADP
admet-782	99	27	the	the	DET
admet-782	99	28	concentration	concentration	NOUN
admet-782	99	29	-	-	PUNCT
admet-782	99	30	detector	detector	NOUN
admet-782	99	31	response	response	NOUN
admet-782	99	32	relationship	relationship	NOUN
admet-782	99	33	.	.	PUNCT
admet-782	100	1	the	the	DET
admet-782	100	2	correlation	correlation	NOUN
admet-782	100	3	coefficients	coefficient	NOUN
admet-782	100	4	(	(	PUNCT
admet-782	100	5	r2	r2	PROPN
admet-782	100	6	)	)	PUNCT
admet-782	100	7	were	be	AUX
admet-782	100	8	more	more	ADJ
admet-782	100	9	than	than	ADP
admet-782	100	10	0.999	0.999	NUM
admet-782	100	11	,	,	PUNCT
admet-782	100	12	indicating	indicate	VERB
admet-782	100	13	an	an	DET
admet-782	100	14	acceptable	acceptable	ADJ
admet-782	100	15	linearity	linearity	NOUN
admet-782	100	16	of	of	ADP
admet-782	100	17	our	our	PRON
admet-782	100	18	method	method	NOUN
admet-782	100	19	.	.	PUNCT
admet-782	101	1	the	the	DET
admet-782	101	2	accuracy	accuracy	NOUN
admet-782	101	3	observed	observe	VERB
admet-782	101	4	for	for	ADP
admet-782	101	5	the	the	DET
admet-782	101	6	mean	mean	NOUN
admet-782	101	7	of	of	ADP
admet-782	101	8	backcalculated	backcalculated	ADJ
admet-782	101	9	concentrations	concentration	NOUN
admet-782	101	10	for	for	ADP
admet-782	101	11	four	four	NUM
admet-782	101	12	calibration	calibration	NOUN
admet-782	101	13	curves	curve	NOUN
admet-782	101	14	was	be	AUX
admet-782	101	15	within	within	ADP
admet-782	101	16	89.3	89.3	NUM
admet-782	101	17	-	-	SYM
admet-782	101	18	109	109	NUM
admet-782	101	19	%	%	NOUN
admet-782	101	20	;	;	PUNCT
admet-782	101	21	while	while	SCONJ
admet-782	101	22	the	the	DET
admet-782	101	23	precision	precision	NOUN
admet-782	101	24	(	(	PUNCT
admet-782	101	25	%	%	INTJ
admet-782	101	26	re	re	NOUN
admet-782	101	27	)	)	PUNCT
admet-782	101	28	values	value	NOUN
admet-782	101	29	ranged	range	VERB
admet-782	101	30	from	from	ADP
admet-782	101	31	0.95	0.95	NUM
admet-782	101	32	-	-	SYM
admet-782	101	33	1.05	1.05	NUM
admet-782	101	34	%	%	NOUN
admet-782	101	35	.	.	PUNCT
admet-782	102	1	we	we	PRON
admet-782	102	2	did	do	AUX
admet-782	102	3	not	not	PART
admet-782	102	4	observe	observe	VERB
admet-782	102	5	any	any	DET
admet-782	102	6	carry	carry	VERB
admet-782	102	7	-	-	PUNCT
admet-782	102	8	over	over	NOUN
admet-782	102	9	produced	produce	VERB
admet-782	102	10	by	by	ADP
admet-782	102	11	the	the	DET
admet-782	102	12	highest	high	ADJ
admet-782	102	13	calibration	calibration	NOUN
admet-782	102	14	sample	sample	NOUN
admet-782	102	15	on	on	ADP
admet-782	102	16	the	the	DET
admet-782	102	17	following	follow	VERB
admet-782	102	18	injected	inject	VERB
admet-782	102	19	mice	mouse	NOUN
admet-782	102	20	blank	blank	ADJ
admet-782	102	21	plasma	plasma	NOUN
admet-782	102	22	extracted	extract	VERB
admet-782	102	23	sample	sample	NOUN
admet-782	102	24	for	for	ADP
admet-782	102	25	copanlisib	copanlisib	PROPN
admet-782	102	26	.	.	PUNCT
admet-782	103	1	figure	figure	VERB
admet-782	103	2	2	2	NUM
admet-782	103	3	.	.	PUNCT
admet-782	104	1	hplc	hplc	NOUN
admet-782	104	2	chromatograms	chromatogram	NOUN
admet-782	104	3	of	of	ADP
admet-782	104	4	a	a	DET
admet-782	104	5	25	25	NUM
admet-782	104	6	µl	µl	ADP
admet-782	104	7	injection	injection	NOUN
admet-782	104	8	of	of	ADP
admet-782	104	9	(	(	PUNCT
admet-782	104	10	a	a	X
admet-782	104	11	)	)	PUNCT
admet-782	104	12	blank	blank	ADJ
admet-782	104	13	mice	mice	NOUN
admet-782	104	14	plasma	plasma	NOUN
admet-782	104	15	(	(	PUNCT
admet-782	104	16	b	b	NOUN
admet-782	104	17	)	)	PUNCT
admet-782	104	18	blank	blank	ADJ
admet-782	104	19	mice	mice	NOUN
admet-782	104	20	plasma	plasma	NOUN
admet-782	104	21	spiked	spike	VERB
admet-782	104	22	with	with	ADP
admet-782	104	23	copanlisib	copanlisib	PROPN
admet-782	104	24	(	(	PUNCT
admet-782	104	25	lloq	lloq	VERB
admet-782	104	26	:	:	PUNCT
admet-782	104	27	50	50	NUM
admet-782	104	28	ng	ng	PROPN
admet-782	104	29	/	/	SYM
admet-782	104	30	ml	ml	NOUN
admet-782	104	31	)	)	PUNCT
admet-782	104	32	along	along	ADP
admet-782	104	33	with	with	ADP
admet-782	104	34	the	the	DET
admet-782	104	35	is	is	NOUN
admet-782	104	36	(	(	PUNCT
admet-782	104	37	c	c	NOUN
admet-782	104	38	)	)	PUNCT
admet-782	104	39	a	a	DET
admet-782	104	40	0.5	0.5	NUM
admet-782	104	41	h	h	NOUN
admet-782	104	42	plasma	plasma	NOUN
admet-782	104	43	sample	sample	NOUN
admet-782	104	44	showing	show	VERB
admet-782	104	45	the	the	DET
admet-782	104	46	peak	peak	NOUN
admet-782	104	47	of	of	ADP
admet-782	104	48	copanlisib	copanlisib	PROPN
admet-782	104	49	(	(	PUNCT
admet-782	104	50	concentration	concentration	NOUN
admet-782	104	51	:	:	PUNCT
admet-782	104	52	3500	3500	NUM
admet-782	104	53	ng	ng	NOUN
admet-782	104	54	/	/	SYM
admet-782	104	55	ml	ml	NOUN
admet-782	104	56	)	)	PUNCT
admet-782	104	57	following	follow	VERB
admet-782	104	58	intravenous	intravenous	ADJ
admet-782	104	59	administration	administration	NOUN
admet-782	104	60	of	of	ADP
admet-782	104	61	copanlisib	copanlisib	PROPN
admet-782	104	62	to	to	PART
admet-782	104	63	mice	mice	VERB
admet-782	104	64	at	at	ADP
admet-782	104	65	5.0	5.0	NUM
admet-782	104	66	mg	mg	NUM
admet-782	104	67	/	/	SYM
admet-782	104	68	kg	kg	PROPN
admet-782	104	69	.	.	PUNCT
admet-782	105	1	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	105	2	r.	r.	PROPN
admet-782	105	3	mullangi	mullangi	VERB
admet-782	105	4	et	et	PROPN
admet-782	105	5	al	al	PROPN
admet-782	105	6	.	.	PROPN
admet-782	105	7	admet	admet	PROPN
admet-782	105	8	&	&	CCONJ
admet-782	105	9	dmpk	dmpk	PROPN
admet-782	105	10	8(1	8(1	NOUN
admet-782	105	11	)	)	PUNCT
admet-782	105	12	(	(	PUNCT
admet-782	105	13	2020	2020	NUM
admet-782	105	14	)	)	PUNCT
admet-782	105	15	113	113	NUM
admet-782	105	16	-	-	SYM
admet-782	105	17	121	121	NUM
admet-782	105	18	118	118	NUM
admet-782	105	19	table	table	NOUN
admet-782	105	20	1	1	NUM
admet-782	105	21	.	.	PUNCT
admet-782	106	1	intraand	intraand	PROPN
admet-782	106	2	inter	inter	ADJ
admet-782	106	3	-	-	ADJ
admet-782	106	4	day	day	ADJ
admet-782	106	5	precision	precision	NOUN
admet-782	106	6	and	and	CCONJ
admet-782	106	7	accuracy	accuracy	NOUN
admet-782	106	8	determination	determination	NOUN
admet-782	106	9	of	of	ADP
admet-782	106	10	copanlisib	copanlisib	PROPN
admet-782	106	11	quality	quality	NOUN
admet-782	106	12	controls	control	NOUN
admet-782	106	13	in	in	ADP
admet-782	106	14	mice	mice	NOUN
admet-782	106	15	plasma	plasma	NOUN
admet-782	106	16	accuracy	accuracy	NOUN
admet-782	106	17	and	and	CCONJ
admet-782	106	18	precision	precision	NOUN
admet-782	106	19	data	datum	NOUN
admet-782	106	20	for	for	ADP
admet-782	106	21	intraand	intraand	NOUN
admet-782	106	22	inter	inter	ADJ
admet-782	106	23	-	-	ADJ
admet-782	106	24	day	day	ADJ
admet-782	106	25	mice	mice	NOUN
admet-782	106	26	plasma	plasma	NOUN
admet-782	106	27	samples	sample	NOUN
admet-782	106	28	determined	determine	VERB
admet-782	106	29	for	for	ADP
admet-782	106	30	copanlisib	copanlisib	PROPN
admet-782	106	31	(	(	PUNCT
admet-782	106	32	from	from	ADP
admet-782	106	33	four	four	NUM
admet-782	106	34	different	different	ADJ
admet-782	106	35	batches	batch	NOUN
admet-782	106	36	)	)	PUNCT
admet-782	106	37	at	at	ADP
admet-782	106	38	lloq	lloq	PROPN
admet-782	106	39	qc	qc	PROPN
admet-782	106	40	(	(	PUNCT
admet-782	106	41	50	50	NUM
admet-782	106	42	ng	ng	PROPN
admet-782	106	43	/	/	SYM
admet-782	106	44	ml	ml	PROPN
admet-782	106	45	)	)	PUNCT
admet-782	106	46	,	,	PUNCT
admet-782	106	47	lqc	lqc	INTJ
admet-782	106	48	(	(	PUNCT
admet-782	106	49	150	150	NUM
admet-782	106	50	ng	ng	NOUN
admet-782	106	51	/	/	SYM
admet-782	106	52	ml	ml	PROPN
admet-782	106	53	)	)	PUNCT
admet-782	106	54	,	,	PUNCT
admet-782	106	55	mqc	mqc	X
admet-782	106	56	(	(	PUNCT
admet-782	106	57	2250	2250	NUM
admet-782	106	58	ng	ng	PROPN
admet-782	106	59	/	/	SYM
admet-782	106	60	ml	ml	PROPN
admet-782	106	61	)	)	PUNCT
admet-782	106	62	and	and	CCONJ
admet-782	106	63	hqc	hqc	INTJ
admet-782	106	64	(	(	PUNCT
admet-782	106	65	3500	3500	NUM
admet-782	106	66	ng	ng	PROPN
admet-782	106	67	/	/	SYM
admet-782	106	68	ml	ml	PROPN
admet-782	106	69	)	)	PUNCT
admet-782	106	70	are	be	AUX
admet-782	106	71	presented	present	VERB
admet-782	106	72	in	in	ADP
admet-782	106	73	table	table	NOUN
admet-782	106	74	1	1	NUM
admet-782	106	75	.	.	PUNCT
admet-782	107	1	the	the	DET
admet-782	107	2	intraand	intraand	NOUN
admet-782	107	3	inter	inter	ADJ
admet-782	107	4	-	-	ADJ
admet-782	107	5	day	day	NOUN
admet-782	107	6	precisions	precision	NOUN
admet-782	107	7	(	(	PUNCT
admet-782	107	8	rsd	rsd	NOUN
admet-782	107	9	)	)	PUNCT
admet-782	107	10	were	be	AUX
admet-782	107	11	within	within	ADP
admet-782	107	12	7.59	7.59	NUM
admet-782	107	13	%	%	NOUN
admet-782	107	14	,	,	PUNCT
admet-782	107	15	and	and	CCONJ
admet-782	107	16	accuracy	accuracy	NOUN
admet-782	107	17	(	(	PUNCT
admet-782	107	18	re	re	NOUN
admet-782	107	19	)	)	PUNCT
admet-782	107	20	ranged	range	VERB
admet-782	107	21	between	between	ADP
admet-782	107	22	0.97	0.97	NUM
admet-782	107	23	-	-	SYM
admet-782	107	24	1.07	1.07	NUM
admet-782	107	25	%	%	NOUN
admet-782	107	26	.	.	PUNCT
admet-782	108	1	the	the	DET
admet-782	108	2	assay	assay	ADJ
admet-782	108	3	values	value	NOUN
admet-782	108	4	on	on	ADP
admet-782	108	5	both	both	CCONJ
admet-782	108	6	the	the	DET
admet-782	108	7	occasions	occasion	NOUN
admet-782	108	8	(	(	PUNCT
admet-782	108	9	intraand	intraand	NOUN
admet-782	108	10	interday	interday	PROPN
admet-782	108	11	)	)	PUNCT
admet-782	108	12	were	be	AUX
admet-782	108	13	found	find	VERB
admet-782	108	14	to	to	PART
admet-782	108	15	be	be	AUX
admet-782	108	16	within	within	ADP
admet-782	108	17	the	the	DET
admet-782	108	18	accepted	accepted	ADJ
admet-782	108	19	variable	variable	ADJ
admet-782	108	20	limits	limit	NOUN
admet-782	108	21	indicating	indicate	VERB
admet-782	108	22	that	that	SCONJ
admet-782	108	23	the	the	DET
admet-782	108	24	present	present	ADJ
admet-782	108	25	method	method	NOUN
admet-782	108	26	is	be	AUX
admet-782	108	27	reproducible	reproducible	ADJ
admet-782	108	28	,	,	PUNCT
admet-782	108	29	accurate	accurate	ADJ
admet-782	108	30	and	and	CCONJ
admet-782	108	31	precise	precise	ADJ
admet-782	108	32	.	.	PUNCT
admet-782	109	1	table	table	NOUN
admet-782	109	2	2	2	NUM
admet-782	109	3	summarizes	summarize	NOUN
admet-782	109	4	the	the	DET
admet-782	109	5	results	result	NOUN
admet-782	109	6	of	of	ADP
admet-782	109	7	stability	stability	NOUN
admet-782	109	8	studies	study	NOUN
admet-782	109	9	conducted	conduct	VERB
admet-782	109	10	for	for	ADP
admet-782	109	11	copanlisib	copanlisib	PROPN
admet-782	109	12	in	in	ADP
admet-782	109	13	mice	mice	NOUN
admet-782	109	14	plasma	plasma	NOUN
admet-782	109	15	.	.	PUNCT
admet-782	110	1	the	the	DET
admet-782	110	2	measured	measure	VERB
admet-782	110	3	concentrations	concentration	NOUN
admet-782	110	4	for	for	ADP
admet-782	110	5	copanlisib	copanlisib	PROPN
admet-782	110	6	at	at	ADP
admet-782	110	7	lqc	lqc	PROPN
admet-782	110	8	(	(	PUNCT
admet-782	110	9	150	150	NUM
admet-782	110	10	ng	ng	NOUN
admet-782	110	11	/	/	SYM
admet-782	110	12	ml	ml	PROPN
admet-782	110	13	)	)	PUNCT
admet-782	110	14	and	and	CCONJ
admet-782	110	15	hqc	hqc	INTJ
admet-782	110	16	(	(	PUNCT
admet-782	110	17	3500	3500	NUM
admet-782	110	18	ng	ng	PROPN
admet-782	110	19	/	/	SYM
admet-782	110	20	ml	ml	NOUN
admet-782	110	21	)	)	PUNCT
admet-782	110	22	deviated	deviate	VERB
admet-782	110	23	within	within	ADP
admet-782	110	24	±15	±15	NOUN
admet-782	110	25	%	%	NOUN
admet-782	110	26	of	of	ADP
admet-782	110	27	the	the	DET
admet-782	110	28	nominal	nominal	ADJ
admet-782	110	29	concentrations	concentration	NOUN
admet-782	110	30	in	in	ADP
admet-782	110	31	a	a	DET
admet-782	110	32	battery	battery	NOUN
admet-782	110	33	of	of	ADP
admet-782	110	34	stability	stability	NOUN
admet-782	110	35	tests	test	VERB
admet-782	110	36	namely	namely	ADV
admet-782	110	37	in	in	ADP
admet-782	110	38	-	-	PUNCT
admet-782	110	39	injector	injector	NOUN
admet-782	110	40	(	(	PUNCT
admet-782	110	41	16	16	NUM
admet-782	110	42	h	h	NOUN
admet-782	110	43	)	)	PUNCT
admet-782	110	44	,	,	PUNCT
admet-782	110	45	benchtop	benchtop	NOUN
admet-782	110	46	(	(	PUNCT
admet-782	110	47	6	6	NUM
admet-782	110	48	h	h	NOUN
admet-782	110	49	)	)	PUNCT
admet-782	110	50	,	,	PUNCT
admet-782	110	51	repeated	repeat	VERB
admet-782	110	52	three	three	NUM
admet-782	110	53	freeze	freeze	NOUN
admet-782	110	54	/	/	SYM
admet-782	110	55	thaw	thaw	NOUN
admet-782	110	56	cycles	cycle	NOUN
admet-782	110	57	and	and	CCONJ
admet-782	110	58	freezer	freezer	NOUN
admet-782	110	59	stability	stability	NOUN
admet-782	110	60	at	at	ADP
admet-782	110	61	-8010	-8010	NOUN
admet-782	111	1	°	°	SCONJ
admet-782	111	2	c	c	NOUN
admet-782	111	3	for	for	ADP
admet-782	111	4	30	30	NUM
admet-782	111	5	days	day	NOUN
admet-782	111	6	(	(	PUNCT
admet-782	111	7	table	table	NOUN
admet-782	111	8	2	2	NUM
admet-782	111	9	)	)	PUNCT
admet-782	111	10	supported	support	VERB
admet-782	111	11	the	the	DET
admet-782	111	12	stability	stability	NOUN
admet-782	111	13	of	of	ADP
admet-782	111	14	copanlisib	copanlisib	PROPN
admet-782	111	15	at	at	ADP
admet-782	111	16	various	various	ADJ
admet-782	111	17	stability	stability	NOUN
admet-782	111	18	conditions	condition	NOUN
admet-782	111	19	.	.	PUNCT
admet-782	112	1	the	the	DET
admet-782	112	2	dilution	dilution	NOUN
admet-782	112	3	integrity	integrity	NOUN
admet-782	112	4	was	be	AUX
admet-782	112	5	confirmed	confirm	VERB
admet-782	112	6	for	for	ADP
admet-782	112	7	qc	qc	PROPN
admet-782	112	8	samples	sample	NOUN
admet-782	112	9	that	that	PRON
admet-782	112	10	exceeded	exceed	VERB
admet-782	112	11	the	the	DET
admet-782	112	12	upper	upper	ADJ
admet-782	112	13	limit	limit	NOUN
admet-782	112	14	of	of	ADP
admet-782	112	15	the	the	DET
admet-782	112	16	quantitation	quantitation	NOUN
admet-782	112	17	(	(	PUNCT
admet-782	112	18	uloq	uloq	NOUN
admet-782	112	19	)	)	PUNCT
admet-782	112	20	of	of	ADP
admet-782	112	21	calibration	calibration	NOUN
admet-782	112	22	curve	curve	NOUN
admet-782	112	23	(	(	PUNCT
admet-782	112	24	up	up	ADP
admet-782	112	25	to	to	PART
admet-782	112	26	35000	35000	NUM
admet-782	112	27	ng	ng	PROPN
admet-782	112	28	/	/	SYM
admet-782	112	29	ml	ml	PROPN
admet-782	112	30	)	)	PUNCT
admet-782	112	31	.	.	PUNCT
admet-782	113	1	the	the	DET
admet-782	113	2	mean	mean	ADJ
admet-782	113	3	accuracy	accuracy	NOUN
admet-782	113	4	and	and	CCONJ
admet-782	113	5	precision	precision	NOUN
admet-782	113	6	for	for	ADP
admet-782	113	7	15	15	NUM
admet-782	113	8	times	time	NOUN
admet-782	113	9	diluted	dilute	VERB
admet-782	113	10	samples	sample	NOUN
admet-782	113	11	were	be	AUX
admet-782	113	12	found	find	VERB
admet-782	113	13	to	to	PART
admet-782	113	14	be	be	AUX
admet-782	113	15	less	less	ADJ
admet-782	113	16	than	than	ADP
admet-782	113	17	7.62	7.62	NUM
admet-782	113	18	and	and	CCONJ
admet-782	113	19	6.25	6.25	NUM
admet-782	113	20	%	%	NOUN
admet-782	113	21	,	,	PUNCT
admet-782	113	22	respectively	respectively	ADV
admet-782	113	23	,	,	PUNCT
admet-782	113	24	which	which	PRON
admet-782	113	25	show	show	VERB
admet-782	113	26	the	the	DET
admet-782	113	27	ability	ability	NOUN
admet-782	113	28	to	to	PART
admet-782	113	29	dilute	dilute	VERB
admet-782	113	30	samples	sample	NOUN
admet-782	113	31	up	up	ADP
admet-782	113	32	to	to	ADP
admet-782	113	33	a	a	DET
admet-782	113	34	dilution	dilution	NOUN
admet-782	113	35	factor	factor	NOUN
admet-782	113	36	of	of	ADP
admet-782	113	37	ten	ten	NUM
admet-782	113	38	in	in	ADP
admet-782	113	39	a	a	DET
admet-782	113	40	linear	linear	ADJ
admet-782	113	41	fashion	fashion	NOUN
admet-782	113	42	(	(	PUNCT
admet-782	113	43	table	table	NOUN
admet-782	113	44	2	2	NUM
admet-782	113	45	)	)	PUNCT
admet-782	113	46	.	.	PUNCT
admet-782	114	1	all	all	DET
admet-782	114	2	the	the	DET
admet-782	114	3	samples	sample	NOUN
admet-782	114	4	selected	select	VERB
admet-782	114	5	for	for	ADP
admet-782	114	6	isr	isr	PROPN
admet-782	114	7	met	meet	VERB
admet-782	114	8	the	the	DET
admet-782	114	9	acceptance	acceptance	NOUN
admet-782	114	10	criteria	criterion	NOUN
admet-782	114	11	.	.	PUNCT
admet-782	115	1	the	the	DET
admet-782	115	2	back	back	ADV
admet-782	115	3	-	-	PUNCT
admet-782	115	4	calculated	calculate	VERB
admet-782	115	5	accuracy	accuracy	NOUN
admet-782	115	6	values	value	NOUN
admet-782	115	7	ranged	range	VERB
admet-782	115	8	between	between	ADP
admet-782	115	9	89.2	89.2	NUM
admet-782	115	10	-	-	SYM
admet-782	115	11	110	110	NUM
admet-782	115	12	%	%	NOUN
admet-782	115	13	from	from	ADP
admet-782	115	14	the	the	DET
admet-782	115	15	initial	initial	ADJ
admet-782	115	16	assay	assay	NOUN
admet-782	115	17	results	result	NOUN
admet-782	115	18	as	as	SCONJ
admet-782	115	19	shown	show	VERB
admet-782	115	20	in	in	ADP
admet-782	115	21	fig	fig	NOUN
admet-782	115	22	.	.	PUNCT
admet-782	116	1	3	3	NUM
admet-782	116	2	using	use	VERB
admet-782	116	3	a	a	DET
admet-782	116	4	bland	bland	ADJ
admet-782	116	5	-	-	PUNCT
admet-782	116	6	altman	altman	NOUN
admet-782	116	7	plot	plot	NOUN
admet-782	116	8	.	.	PUNCT
admet-782	117	1	pharmacokinetic	pharmacokinetic	ADJ
admet-782	117	2	study	study	NOUN
admet-782	117	3	plasma	plasma	NOUN
admet-782	117	4	samples	sample	NOUN
admet-782	117	5	collected	collect	VERB
admet-782	117	6	during	during	ADP
admet-782	117	7	pharmacokinetic	pharmacokinetic	ADJ
admet-782	117	8	study	study	NOUN
admet-782	117	9	were	be	AUX
admet-782	117	10	thawed	thaw	VERB
admet-782	117	11	at	at	ADP
admet-782	117	12	room	room	NOUN
admet-782	117	13	temperature	temperature	NOUN
admet-782	117	14	and	and	CCONJ
admet-782	117	15	processed	process	VERB
admet-782	117	16	as	as	SCONJ
admet-782	117	17	mentioned	mention	VERB
admet-782	117	18	in	in	ADP
admet-782	117	19	sample	sample	NOUN
admet-782	117	20	preparation	preparation	NOUN
admet-782	117	21	section	section	NOUN
admet-782	117	22	.	.	PUNCT
admet-782	118	1	along	along	ADP
admet-782	118	2	with	with	ADP
admet-782	118	3	plasma	plasma	NOUN
admet-782	118	4	samples	sample	NOUN
admet-782	118	5	,	,	PUNCT
admet-782	118	6	lqc	lqc	INTJ
admet-782	118	7	,	,	PUNCT
admet-782	118	8	mqc	mqc	PROPN
admet-782	118	9	and	and	CCONJ
admet-782	118	10	hqc	hqc	PROPN
admet-782	118	11	samples	sample	NOUN
admet-782	118	12	(	(	PUNCT
admet-782	118	13	made	make	VERB
admet-782	118	14	in	in	ADP
admet-782	118	15	blank	blank	ADJ
admet-782	118	16	plasma	plasma	NOUN
admet-782	118	17	)	)	PUNCT
admet-782	118	18	were	be	AUX
admet-782	118	19	assayed	assayed	ADJ
admet-782	118	20	in	in	ADP
admet-782	118	21	duplicate	duplicate	NOUN
admet-782	118	22	and	and	CCONJ
admet-782	118	23	were	be	AUX
admet-782	118	24	distributed	distribute	VERB
admet-782	118	25	among	among	ADP
admet-782	118	26	unknown	unknown	ADJ
admet-782	118	27	samples	sample	NOUN
admet-782	118	28	in	in	ADP
admet-782	118	29	the	the	DET
admet-782	118	30	analytical	analytical	ADJ
admet-782	118	31	run	run	NOUN
admet-782	118	32	.	.	PUNCT
admet-782	119	1	plasma	plasma	NOUN
admet-782	119	2	samples	sample	NOUN
admet-782	119	3	showed	show	VERB
admet-782	119	4	high	high	ADJ
admet-782	119	5	concentration	concentration	NOUN
admet-782	119	6	above	above	ADP
admet-782	119	7	the	the	DET
admet-782	119	8	high	high	ADJ
admet-782	119	9	calibration	calibration	NOUN
admet-782	119	10	standard	standard	NOUN
admet-782	119	11	(	(	PUNCT
admet-782	119	12	5.00	5.00	NUM
admet-782	119	13	µg	µg	NOUN
admet-782	119	14	/	/	SYM
admet-782	119	15	ml	ml	NOUN
admet-782	119	16	)	)	PUNCT
admet-782	119	17	were	be	AUX
admet-782	119	18	diluted	dilute	VERB
admet-782	119	19	appropriately	appropriately	ADV
admet-782	119	20	with	with	ADP
admet-782	119	21	mice	mouse	NOUN
admet-782	119	22	blank	blank	ADJ
admet-782	119	23	plasma	plasma	NOUN
admet-782	119	24	to	to	PART
admet-782	119	25	bring	bring	VERB
admet-782	119	26	the	the	DET
admet-782	119	27	concentration	concentration	NOUN
admet-782	119	28	within	within	ADP
admet-782	119	29	linearity	linearity	NOUN
admet-782	119	30	range	range	NOUN
admet-782	119	31	.	.	PUNCT
admet-782	120	1	the	the	DET
admet-782	120	2	criteria	criterion	NOUN
admet-782	120	3	for	for	ADP
admet-782	120	4	acceptance	acceptance	NOUN
admet-782	120	5	of	of	ADP
admet-782	120	6	the	the	DET
admet-782	120	7	analytical	analytical	ADJ
admet-782	120	8	runs	run	NOUN
admet-782	120	9	encompassed	encompass	VERB
admet-782	120	10	the	the	DET
admet-782	120	11	following	following	NOUN
admet-782	120	12	:	:	PUNCT
admet-782	120	13	(	(	PUNCT
admet-782	120	14	i	i	NOUN
admet-782	120	15	)	)	PUNCT
admet-782	120	16	≥67	≥67	X
admet-782	120	17	%	%	NOUN
admet-782	120	18	of	of	ADP
admet-782	120	19	qc	qc	PROPN
admet-782	120	20	theoretical	theoretical	ADJ
admet-782	120	21	concentration	concentration	NOUN
admet-782	120	22	(	(	PUNCT
admet-782	120	23	ng	ng	NOUN
admet-782	120	24	/	/	SYM
admet-782	120	25	ml	ml	NOUN
admet-782	120	26	)	)	PUNCT
admet-782	120	27	batch	batch	NOUN
admet-782	120	28	measured	measure	VERB
admet-782	120	29	concentration	concentration	NOUN
admet-782	120	30	(	(	PUNCT
admet-782	120	31	ng	ng	NOUN
admet-782	120	32	/	/	SYM
admet-782	120	33	ml	ml	NOUN
admet-782	120	34	)	)	PUNCT
admet-782	120	35	mean	mean	NOUN
admet-782	120	36	±	±	PROPN
admet-782	120	37	sd	sd	ADP
admet-782	120	38	rsd	rsd	PROPN
admet-782	120	39	accuracy	accuracy	NOUN
admet-782	120	40	,	,	PUNCT
admet-782	120	41	%	%	NOUN
admet-782	120	42	intra	intra	ADJ
admet-782	120	43	-	-	NOUN
admet-782	120	44	day	day	NOUN
admet-782	120	45	(	(	PUNCT
admet-782	120	46	six	six	NUM
admet-782	120	47	replicates	replicate	NOUN
admet-782	120	48	at	at	ADP
admet-782	120	49	each	each	DET
admet-782	120	50	concentration	concentration	NOUN
admet-782	120	51	)	)	PUNCT
admet-782	120	52	50.0	50.0	NUM
admet-782	120	53	1	1	NUM
admet-782	120	54	49.4	49.4	NUM
admet-782	120	55	±	±	NUM
admet-782	120	56	4.76	4.76	NUM
admet-782	120	57	9.63	9.63	NUM
admet-782	120	58	98.9	98.9	NUM
admet-782	120	59	2	2	NUM
admet-782	120	60	50.8	50.8	NUM
admet-782	120	61	±	±	NUM
admet-782	120	62	3.89	3.89	NUM
admet-782	120	63	7.65	7.65	NUM
admet-782	120	64	101	101	NUM
admet-782	120	65	3	3	NUM
admet-782	120	66	54.3	54.3	NUM
admet-782	120	67	±	±	NUM
admet-782	120	68	1.35	1.35	NUM
admet-782	120	69	2.49	2.49	NUM
admet-782	120	70	108	108	NUM
admet-782	120	71	4	4	NUM
admet-782	120	72	51.0	51.0	NUM
admet-782	120	73	±	±	NUM
admet-782	120	74	3.26	3.26	NUM
admet-782	120	75	6.53	6.53	NUM
admet-782	120	76	103	103	NUM
admet-782	120	77	150	150	NUM
admet-782	120	78	1	1	NUM
admet-782	120	79	139	139	NUM
admet-782	120	80	±	±	NUM
admet-782	120	81	1.95	1.95	NUM
admet-782	120	82	1.39	1.39	NUM
admet-782	120	83	93.2	93.2	NUM
admet-782	120	84	2	2	NUM
admet-782	120	85	151	151	NUM
admet-782	120	86	±	±	NUM
admet-782	120	87	5.77	5.77	NUM
admet-782	120	88	3.80	3.80	NUM
admet-782	120	89	101	101	NUM
admet-782	120	90	3	3	NUM
admet-782	120	91	146	146	NUM
admet-782	120	92	±	±	NUM
admet-782	120	93	2.88	2.88	NUM
admet-782	120	94	1.98	1.98	NUM
admet-782	120	95	97.3	97.3	NUM
admet-782	120	96	4	4	NUM
admet-782	120	97	145	145	NUM
admet-782	120	98	±	±	NUM
admet-782	120	99	3.46	3.46	NUM
admet-782	120	100	2.36	2.36	NUM
admet-782	120	101	97.3	97.3	NUM
admet-782	120	102	2250	2250	NUM
admet-782	120	103	1	1	NUM
admet-782	120	104	2155	2155	NUM
admet-782	120	105	±	±	NUM
admet-782	120	106	46.5	46.5	NUM
admet-782	120	107	2.16	2.16	NUM
admet-782	120	108	95.8	95.8	NUM
admet-782	120	109	2	2	NUM
admet-782	120	110	2120	2120	NUM
admet-782	120	111	±	±	NUM
admet-782	120	112	78.9	78.9	NUM
admet-782	120	113	3.72	3.72	NUM
admet-782	120	114	94.2	94.2	NUM
admet-782	120	115	3	3	NUM
admet-782	120	116	2297	2297	NUM
admet-782	120	117	±	±	NUM
admet-782	120	118	38.1	38.1	NUM
admet-782	120	119	1.66	1.66	NUM
admet-782	120	120	102	102	NUM
admet-782	120	121	4	4	NUM
admet-782	120	122	2190	2190	NUM
admet-782	120	123	±	±	NUM
admet-782	120	124	54.1	54.1	NUM
admet-782	120	125	2.50	2.50	NUM
admet-782	120	126	97.4	97.4	NUM
admet-782	120	127	3500	3500	NUM
admet-782	120	128	1	1	NUM
admet-782	120	129	3460	3460	NUM
admet-782	120	130	±	±	NUM
admet-782	120	131	81.2	81.2	NUM
admet-782	120	132	2.32	2.32	NUM
admet-782	120	133	112	112	NUM
admet-782	120	134	2	2	NUM
admet-782	120	135	3507	3507	NUM
admet-782	120	136	±	±	NUM
admet-782	120	137	70.0	70.0	NUM
admet-782	120	138	2.00	2.00	NUM
admet-782	120	139	104	104	NUM
admet-782	120	140	3	3	NUM
admet-782	120	141	3545	3545	NUM
admet-782	120	142	±	±	NUM
admet-782	120	143	53.3	53.3	NUM
admet-782	120	144	1.50	1.50	NUM
admet-782	120	145	105	105	NUM
admet-782	120	146	4	4	NUM
admet-782	120	147	3516	3516	NUM
admet-782	120	148	±	±	NUM
admet-782	120	149	68.1	68.1	NUM
admet-782	120	150	1.94	1.94	NUM
admet-782	120	151	107	107	NUM
admet-782	120	152	inter	inter	ADJ
admet-782	120	153	-	-	NOUN
admet-782	120	154	day	day	NOUN
admet-782	120	155	(	(	PUNCT
admet-782	120	156	twenty	twenty	NUM
admet-782	120	157	four	four	NUM
admet-782	120	158	replicates	replicate	NOUN
admet-782	120	159	at	at	ADP
admet-782	120	160	each	each	DET
admet-782	120	161	concentration	concentration	NOUN
admet-782	120	162	)	)	PUNCT
admet-782	120	163	50.0	50.0	NUM
admet-782	120	164	51.2	51.2	NUM
admet-782	120	165	±	±	NUM
admet-782	120	166	3.91	3.91	NUM
admet-782	120	167	7.59	7.59	NUM
admet-782	120	168	103	103	NUM
admet-782	120	169	150	150	NUM
admet-782	120	170	146	146	NUM
admet-782	120	171	±	±	NUM
admet-782	120	172	6.22	6.22	NUM
admet-782	120	173	4.28	4.28	NUM
admet-782	120	174	97.3	97.3	NUM
admet-782	120	175	2250	2250	NUM
admet-782	120	176	2190	2190	NUM
admet-782	120	177	±	±	NUM
admet-782	120	178	95.1	95.1	NUM
admet-782	120	179	4.35	4.35	NUM
admet-782	120	180	96.9	96.9	NUM
admet-782	120	181	3500	3500	NUM
admet-782	120	182	3504	3504	NUM
admet-782	120	183	±	±	NUM
admet-782	120	184	72.0	72.0	NUM
admet-782	120	185	2.06	2.06	NUM
admet-782	120	186	99.9	99.9	NUM
admet-782	120	187	rsd	rsd	NOUN
admet-782	120	188	:	:	PUNCT
admet-782	120	189	relative	relative	ADJ
admet-782	120	190	standard	standard	ADJ
admet-782	120	191	deviation	deviation	NOUN
admet-782	120	192	(	(	PUNCT
admet-782	120	193	sd	sd	PART
admet-782	120	194			VERB
admet-782	120	195	100	100	NUM
admet-782	120	196	/	/	SYM
admet-782	120	197	mean	mean	VERB
admet-782	120	198	)	)	PUNCT
admet-782	120	199	re	re	ADP
admet-782	120	200	:	:	PUNCT
admet-782	120	201	relative	relative	ADJ
admet-782	120	202	error	error	NOUN
admet-782	120	203	(	(	PUNCT
admet-782	120	204	measured	measure	VERB
admet-782	120	205	value	value	NOUN
admet-782	120	206	/	/	SYM
admet-782	120	207	actual	actual	ADJ
admet-782	120	208	value	value	NOUN
admet-782	120	209	)	)	PUNCT
admet-782	120	210	sd	sd	NOUN
admet-782	120	211	:	:	PUNCT
admet-782	120	212	standard	standard	ADJ
admet-782	120	213	deviation	deviation	NOUN
admet-782	120	214	admet	admet	PROPN
admet-782	120	215	&	&	CCONJ
admet-782	120	216	dmpk	dmpk	PROPN
admet-782	120	217	8(1	8(1	NOUN
admet-782	120	218	)	)	PUNCT
admet-782	120	219	(	(	PUNCT
admet-782	120	220	2020	2020	NUM
admet-782	120	221	)	)	PUNCT
admet-782	120	222	113	113	NUM
admet-782	120	223	-	-	SYM
admet-782	120	224	121	121	NUM
admet-782	120	225	copanlisib	copanlisib	NOUN
admet-782	120	226	quantification	quantification	NOUN
admet-782	120	227	by	by	ADP
admet-782	120	228	hplc	hplc	NOUN
admet-782	120	229	in	in	ADP
admet-782	120	230	mice	mice	NOUN
admet-782	120	231	plasma	plasma	NOUN
admet-782	120	232	doi	doi	PROPN
admet-782	120	233	:	:	PUNCT
admet-782	120	234	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	120	235	119	119	NUM
admet-782	120	236	samples	sample	NOUN
admet-782	120	237	should	should	AUX
admet-782	120	238	be	be	AUX
admet-782	120	239	±15	±15	NOUN
admet-782	120	240	%	%	NOUN
admet-782	120	241	of	of	ADP
admet-782	120	242	the	the	DET
admet-782	120	243	nominal	nominal	ADJ
admet-782	120	244	concentration	concentration	NOUN
admet-782	120	245	values	value	NOUN
admet-782	120	246	(	(	PUNCT
admet-782	120	247	ii	ii	NOUN
admet-782	120	248	)	)	PUNCT
admet-782	120	249	≥	≥	NOUN
admet-782	120	250	50	50	NUM
admet-782	120	251	%	%	NOUN
admet-782	120	252	of	of	ADP
admet-782	120	253	qc	qc	PROPN
admet-782	120	254	samples	sample	NOUN
admet-782	120	255	per	per	ADP
admet-782	120	256	level	level	NOUN
admet-782	120	257	should	should	AUX
admet-782	120	258	be	be	AUX
admet-782	120	259	±15	±15	NOUN
admet-782	120	260	%	%	NOUN
admet-782	120	261	of	of	ADP
admet-782	120	262	their	their	PRON
admet-782	120	263	nominal	nominal	ADJ
admet-782	120	264	concentration	concentration	NOUN
admet-782	120	265	values	value	NOUN
admet-782	120	266	[	[	X
admet-782	120	267	12	12	NUM
admet-782	120	268	]	]	PUNCT
admet-782	120	269	.	.	PUNCT
admet-782	121	1	table	table	NOUN
admet-782	121	2	2	2	NUM
admet-782	121	3	.	.	X
admet-782	121	4	stability	stability	NOUN
admet-782	121	5	and	and	CCONJ
admet-782	121	6	dilution	dilution	NOUN
admet-782	121	7	integrity	integrity	NOUN
admet-782	121	8	data	datum	NOUN
admet-782	121	9	for	for	ADP
admet-782	121	10	copanlisib	copanlisib	PROPN
admet-782	121	11	in	in	ADP
admet-782	121	12	mice	mice	NOUN
admet-782	121	13	plasma	plasma	NOUN
admet-782	121	14	experiment	experiment	NOUN
admet-782	121	15	spiked	spike	VERB
admet-782	121	16	concentration	concentration	NOUN
admet-782	121	17	(	(	PUNCT
admet-782	121	18	ng	ng	NOUN
admet-782	121	19	/	/	SYM
admet-782	121	20	ml	ml	NOUN
admet-782	121	21	)	)	PUNCT
admet-782	121	22	measured	measure	VERB
admet-782	121	23	concentration	concentration	NOUN
admet-782	121	24	(	(	PUNCT
admet-782	121	25	ng	ng	NOUN
admet-782	121	26	/	/	SYM
admet-782	121	27	ml	ml	NOUN
admet-782	121	28	)	)	PUNCT
admet-782	121	29	mean	mean	VERB
admet-782	121	30	±	±	NUM
admet-782	121	31	sd	sd	ADP
admet-782	121	32	a	a	DET
admet-782	121	33	(	(	PUNCT
admet-782	121	34	n	n	NOUN
admet-782	121	35	=	=	SYM
admet-782	121	36	6	6	NUM
admet-782	121	37	)	)	PUNCT
admet-782	121	38	accuracy	accuracy	NOUN
admet-782	121	39	(	(	PUNCT
admet-782	121	40	%	%	INTJ
admet-782	122	1	)	)	PUNCT
admet-782	122	2	b	b	NOUN
admet-782	122	3	precision	precision	NOUN
admet-782	122	4	(	(	PUNCT
admet-782	122	5	%	%	INTJ
admet-782	122	6	cv	cv	ADJ
admet-782	122	7	)	)	PUNCT
admet-782	122	8	bench	bench	NOUN
admet-782	122	9	-	-	PUNCT
admet-782	122	10	top	top	NOUN
admet-782	122	11	(	(	PUNCT
admet-782	122	12	6	6	NUM
admet-782	122	13	h	h	NOUN
admet-782	122	14	)	)	PUNCT
admet-782	122	15	stability	stability	NOUN
admet-782	122	16	150	150	NUM
admet-782	122	17	150	150	NUM
admet-782	122	18	±	±	NUM
admet-782	122	19	2.72	2.72	NUM
admet-782	122	20	99.8	99.8	NUM
admet-782	122	21	1.80	1.80	NUM
admet-782	122	22	3500	3500	NUM
admet-782	122	23	3548	3548	NUM
admet-782	122	24	±	±	NOUN
admet-782	122	25	66.6	66.6	NUM
admet-782	122	26	101	101	NUM
admet-782	122	27	1.88	1.88	NUM
admet-782	122	28	in	in	ADP
admet-782	122	29	-	-	PUNCT
admet-782	122	30	injector	injector	NOUN
admet-782	122	31	(	(	PUNCT
admet-782	122	32	16	16	NUM
admet-782	122	33	h	h	NOUN
admet-782	122	34	)	)	PUNCT
admet-782	122	35	stability	stability	NOUN
admet-782	122	36	150	150	NUM
admet-782	122	37	146	146	NUM
admet-782	122	38	±	±	NUM
admet-782	122	39	4.77	4.77	NUM
admet-782	122	40	98.0	98.0	NUM
admet-782	122	41	3.25	3.25	NUM
admet-782	122	42	3500	3500	NUM
admet-782	122	43	3808	3808	NUM
admet-782	122	44	±	±	NUM
admet-782	122	45	34.0	34.0	NUM
admet-782	122	46	107	107	NUM
admet-782	122	47	0.89	0.89	NUM
admet-782	122	48	freeze	freeze	NOUN
admet-782	122	49	-	-	PUNCT
admet-782	122	50	thaw	thaw	NOUN
admet-782	122	51	(	(	PUNCT
admet-782	122	52	3	3	NUM
admet-782	122	53	cycles	cycle	NOUN
admet-782	122	54	)	)	PUNCT
admet-782	122	55	stability	stability	NOUN
admet-782	122	56	150	150	NUM
admet-782	122	57	159	159	NUM
admet-782	122	58	±	±	NUM
admet-782	122	59	12.3	12.3	NUM
admet-782	122	60	106	106	NUM
admet-782	122	61	7.70	7.70	NUM
admet-782	122	62	3500	3500	NUM
admet-782	122	63	3774	3774	NUM
admet-782	122	64	±	±	NOUN
admet-782	122	65	107	107	NUM
admet-782	122	66	107	107	NUM
admet-782	122	67	2.84	2.84	NUM
admet-782	122	68	long	long	ADJ
admet-782	122	69	-	-	PUNCT
admet-782	122	70	term	term	NOUN
admet-782	122	71	stability	stability	NOUN
admet-782	122	72	at	at	ADP
admet-782	122	73	-80	-80	NOUN
admet-782	122	74	°	°	PROPN
admet-782	122	75	c	c	NOUN
admet-782	122	76	(	(	PUNCT
admet-782	122	77	30	30	NUM
admet-782	122	78	days	day	NOUN
admet-782	122	79	)	)	PUNCT
admet-782	122	80	150	150	NUM
admet-782	122	81	146	146	NUM
admet-782	122	82	±	±	NUM
admet-782	122	83	3.44	3.44	NUM
admet-782	122	84	97.3	97.3	NUM
admet-782	122	85	2.35	2.35	NUM
admet-782	122	86	3500	3500	NUM
admet-782	122	87	3758	3758	NUM
admet-782	122	88	±	±	NOUN
admet-782	122	89	23.0	23.0	NUM
admet-782	122	90	106	106	NUM
admet-782	122	91	0.61	0.61	NUM
admet-782	122	92	*	*	PUNCT
admet-782	122	93	dilution	dilution	NOUN
admet-782	122	94	integrity	integrity	NOUN
admet-782	122	95	2333	2333	NUM
admet-782	122	96	2522	2522	NUM
admet-782	122	97	±	±	NUM
admet-782	122	98	403	403	NUM
admet-782	122	99	108	108	NUM
admet-782	122	100	6.25	6.25	NUM
admet-782	122	101	rsd	rsd	NOUN
admet-782	122	102	:	:	PUNCT
admet-782	122	103	relative	relative	ADJ
admet-782	122	104	standard	standard	ADJ
admet-782	122	105	deviation	deviation	NOUN
admet-782	122	106	(	(	PUNCT
admet-782	122	107	sd	sd	NOUN
admet-782	122	108	x	x	SYM
admet-782	122	109	100	100	NUM
admet-782	122	110	/	/	SYM
admet-782	122	111	mean	mean	NOUN
admet-782	122	112	)	)	PUNCT
admet-782	122	113	re	re	ADP
admet-782	122	114	:	:	PUNCT
admet-782	122	115	relative	relative	ADJ
admet-782	122	116	error	error	NOUN
admet-782	122	117	(	(	PUNCT
admet-782	122	118	measured	measure	VERB
admet-782	122	119	value	value	NOUN
admet-782	122	120	/	/	SYM
admet-782	122	121	actual	actual	ADJ
admet-782	122	122	value	value	NOUN
admet-782	122	123	)	)	PUNCT
admet-782	122	124	*	*	PUNCT
admet-782	123	1	plasma	plasma	NOUN
admet-782	123	2	samples	sample	NOUN
admet-782	123	3	prepared	prepare	VERB
admet-782	123	4	at	at	ADP
admet-782	123	5	35,000	35,000	NUM
admet-782	123	6	ng	ng	NOUN
admet-782	123	7	/	/	SYM
admet-782	123	8	ml	ml	PROPN
admet-782	123	9	(	(	PUNCT
admet-782	123	10	10	10	NUM
admet-782	123	11	-	-	NOUN
admet-782	123	12	fold	fold	VERB
admet-782	123	13	above	above	ADP
admet-782	123	14	hqc	hqc	PROPN
admet-782	123	15	)	)	PUNCT
admet-782	123	16	diluted	dilute	VERB
admet-782	123	17	with	with	ADP
admet-782	123	18	blank	blank	ADJ
admet-782	123	19	plasma	plasma	NOUN
admet-782	123	20	by	by	ADP
admet-782	123	21	15	15	NUM
admet-782	123	22	-	-	NOUN
admet-782	123	23	fold	fold	ADJ
admet-782	123	24	and	and	CCONJ
admet-782	123	25	analyzed	analyze	VERB
admet-782	123	26	figure	figure	NOUN
admet-782	123	27	3	3	NUM
admet-782	123	28	.	.	PUNCT
admet-782	123	29	bland	bland	ADJ
admet-782	123	30	-	-	PUNCT
admet-782	123	31	altman	altman	NOUN
admet-782	123	32	plot	plot	NOUN
admet-782	123	33	showing	show	VERB
admet-782	123	34	the	the	DET
admet-782	123	35	incurred	incurred	ADJ
admet-782	123	36	sample	sample	NOUN
admet-782	123	37	reanalysis	reanalysis	NOUN
admet-782	123	38	(	(	PUNCT
admet-782	123	39	isr	isr	NOUN
admet-782	123	40	)	)	PUNCT
admet-782	123	41	data	datum	NOUN
admet-782	123	42	for	for	ADP
admet-782	123	43	copanlisib	copanlisib	PROPN
admet-782	123	44	in	in	ADP
admet-782	123	45	the	the	DET
admet-782	123	46	mice	mouse	NOUN
admet-782	123	47	,	,	PUNCT
admet-782	123	48	plasma	plasma	NOUN
admet-782	123	49	concentrations	concentration	NOUN
admet-782	123	50	of	of	ADP
admet-782	123	51	copanlisib	copanlisib	PROPN
admet-782	123	52	decreased	decrease	VERB
admet-782	123	53	mono	mono	NOUN
admet-782	123	54	-	-	PUNCT
admet-782	123	55	exponentially	exponentially	ADV
admet-782	123	56	after	after	ADP
admet-782	123	57	intravenous	intravenous	ADJ
admet-782	123	58	administration	administration	NOUN
admet-782	123	59	.	.	PUNCT
admet-782	124	1	fig	fig	NOUN
admet-782	124	2	.	.	PUNCT
admet-782	125	1	4	4	NUM
admet-782	125	2	depicts	depict	VERB
admet-782	125	3	the	the	DET
admet-782	125	4	mean	mean	ADJ
admet-782	125	5	±	±	PROPN
admet-782	125	6	s.d	s.d	PROPN
admet-782	125	7	plasma	plasma	NOUN
admet-782	125	8	concentrations	concentration	NOUN
admet-782	125	9	versus	versus	ADP
admet-782	125	10	time	time	NOUN
admet-782	125	11	for	for	ADP
admet-782	125	12	copanlisib	copanlisib	PROPN
admet-782	125	13	following	follow	VERB
admet-782	125	14	intravenous	intravenous	ADJ
admet-782	125	15	administration	administration	NOUN
admet-782	125	16	to	to	PART
admet-782	125	17	mice	mice	VERB
admet-782	125	18	at	at	ADP
admet-782	125	19	5.0	5.0	NUM
admet-782	125	20	mg	mg	NUM
admet-782	125	21	/	/	SYM
admet-782	125	22	kg	kg	PROPN
admet-782	125	23	.	.	PUNCT
admet-782	125	24	copanlisib	copanlisib	PROPN
admet-782	125	25	was	be	AUX
admet-782	125	26	quantifiable	quantifiable	ADJ
admet-782	125	27	up	up	ADP
admet-782	125	28	to	to	PART
admet-782	125	29	8.0	8.0	NUM
admet-782	125	30	h	h	NOUN
admet-782	125	31	post	post	PROPN
admet-782	125	32	intravenous	intravenous	ADJ
admet-782	125	33	administration	administration	NOUN
admet-782	125	34	to	to	PART
admet-782	125	35	mice	mice	VERB
admet-782	125	36	.	.	PUNCT
admet-782	126	1	post	post	VERB
admet-782	126	2	intravenous	intravenous	ADJ
admet-782	126	3	administration	administration	NOUN
admet-782	126	4	,	,	PUNCT
admet-782	126	5	the	the	DET
admet-782	126	6	cl	cl	NOUN
admet-782	126	7	and	and	CCONJ
admet-782	126	8	vd	vd	NOUN
admet-782	126	9	were	be	AUX
admet-782	126	10	found	find	VERB
admet-782	126	11	to	to	PART
admet-782	126	12	be	be	AUX
admet-782	126	13	42.1	42.1	NUM
admet-782	126	14	ml	ml	NOUN
admet-782	126	15	/	/	SYM
admet-782	126	16	min	min	NOUN
admet-782	126	17	/	/	SYM
admet-782	126	18	kg	kg	PROPN
admet-782	126	19	and	and	CCONJ
admet-782	126	20	27.6	27.6	NUM
admet-782	126	21	l	l	NOUN
admet-782	126	22	/	/	SYM
admet-782	126	23	kg	kg	PROPN
admet-782	126	24	,	,	PUNCT
admet-782	126	25	respectively	respectively	ADV
admet-782	126	26	.	.	PUNCT
admet-782	127	1	the	the	DET
admet-782	127	2	auc0-∞	auc0-∞	NUM
admet-782	127	3	attained	attain	VERB
admet-782	127	4	post	post	PROPN
admet-782	127	5	intravenous	intravenous	ADJ
admet-782	127	6	administration	administration	NOUN
admet-782	127	7	was	be	AUX
admet-782	127	8	1978	1978	NUM
admet-782	127	9	(	(	PUNCT
admet-782	127	10	ng	ng	PROPN
admet-782	127	11	h)/ml	h)/ml	PROPN
admet-782	127	12	.	.	PUNCT
admet-782	128	1	the	the	DET
admet-782	128	2	t½	t½	NOUN
admet-782	128	3	was	be	AUX
admet-782	128	4	7.58	7.58	NUM
admet-782	128	5	h.	h.	NOUN
admet-782	128	6	in	in	ADP
admet-782	128	7	summary	summary	NOUN
admet-782	128	8	the	the	DET
admet-782	128	9	validated	validate	VERB
admet-782	128	10	method	method	NOUN
admet-782	128	11	was	be	AUX
admet-782	128	12	sensitive	sensitive	ADJ
admet-782	128	13	enough	enough	ADV
admet-782	128	14	to	to	PART
admet-782	128	15	calculate	calculate	VERB
admet-782	128	16	the	the	DET
admet-782	128	17	pharmacokinetic	pharmacokinetic	ADJ
admet-782	128	18	parameters	parameter	NOUN
admet-782	128	19	of	of	ADP
admet-782	128	20	copanlisib	copanlisib	PROPN
admet-782	128	21	.	.	PUNCT
admet-782	129	1	patnaik	patnaik	PROPN
admet-782	129	2	et	et	PROPN
admet-782	129	3	al	al	PROPN
admet-782	129	4	.	.	PUNCT
admet-782	130	1	[	[	X
admet-782	130	2	10	10	NUM
admet-782	130	3	]	]	PUNCT
admet-782	130	4	and	and	CCONJ
admet-782	130	5	kim	kim	PROPN
admet-782	130	6	et	et	PROPN
admet-782	130	7	al	al	PROPN
admet-782	130	8	.	.	PUNCT
admet-782	131	1	[	[	X
admet-782	131	2	11	11	NUM
admet-782	131	3	]	]	PUNCT
admet-782	131	4	reported	report	VERB
admet-782	131	5	the	the	DET
admet-782	131	6	plasma	plasma	NOUN
admet-782	131	7	concentrations	concentration	NOUN
admet-782	131	8	of	of	ADP
admet-782	131	9	copanlisib	copanlisib	PROPN
admet-782	131	10	post	post	PROPN
admet-782	131	11	administration	administration	PROPN
admet-782	131	12	at	at	ADP
admet-782	131	13	efficacy	efficacy	PROPN
admet-782	131	14	dose	dose	PROPN
admet-782	131	15	(	(	PUNCT
admet-782	131	16	0.8	0.8	NUM
admet-782	131	17	mg	mg	PROPN
admet-782	131	18	/	/	SYM
admet-782	131	19	kg	kg	PROPN
admet-782	131	20	as	as	ADP
admet-782	131	21	1	1	NUM
admet-782	131	22	h	h	NOUN
admet-782	131	23	intravenous	intravenous	ADJ
admet-782	131	24	infusion	infusion	NOUN
admet-782	131	25	)	)	PUNCT
admet-782	131	26	to	to	ADP
admet-782	131	27	patients	patient	NOUN
admet-782	131	28	with	with	ADP
admet-782	131	29	advanced	advanced	ADJ
admet-782	131	30	solid	solid	ADJ
admet-782	131	31	tumors	tumor	NOUN
admet-782	131	32	and	and	CCONJ
admet-782	131	33	non	non	ADJ
admet-782	131	34	-	-	ADJ
admet-782	131	35	hodgkin	hodgkin	ADJ
admet-782	131	36	’s	’s	PART
admet-782	131	37	lymphoma	lymphoma	NOUN
admet-782	131	38	.	.	PUNCT
admet-782	132	1	plasma	plasma	NOUN
admet-782	132	2	samples	sample	NOUN
admet-782	132	3	collected	collect	VERB
admet-782	132	4	in	in	ADP
admet-782	132	5	these	these	DET
admet-782	132	6	studies	study	NOUN
admet-782	132	7	on	on	ADP
admet-782	132	8	day-1	day-1	NUM
admet-782	132	9	and	and	CCONJ
admet-782	132	10	day-15	day-15	PROPN
admet-782	132	11	were	be	AUX
admet-782	132	12	analyzed	analyze	VERB
admet-782	132	13	using	use	VERB
admet-782	132	14	an	an	DET
admet-782	132	15	lc	lc	NOUN
admet-782	132	16	-	-	PUNCT
admet-782	132	17	ms	ms	PROPN
admet-782	132	18	/	/	SYM
admet-782	132	19	ms	ms	PROPN
admet-782	132	20	method	method	NOUN
admet-782	132	21	.	.	PUNCT
admet-782	133	1	we	we	PRON
admet-782	133	2	have	have	AUX
admet-782	133	3	digitalized	digitalize	VERB
admet-782	133	4	the	the	DET
admet-782	133	5	reported	report	VERB
admet-782	133	6	plasma	plasma	NOUN
admet-782	133	7	concentrations	concentration	NOUN
admet-782	133	8	versus	versus	ADP
admet-782	133	9	time	time	NOUN
admet-782	133	10	plots	plot	NOUN
admet-782	133	11	of	of	ADP
admet-782	133	12	copanlisib	copanlisib	PROPN
admet-782	133	13	reported	report	VERB
admet-782	133	14	by	by	ADP
admet-782	133	15	patnaik	patnaik	PROPN
admet-782	133	16	et	et	PROPN
admet-782	133	17	al	al	PROPN
admet-782	133	18	.	.	PUNCT
admet-782	134	1	[	[	X
admet-782	134	2	10	10	NUM
admet-782	134	3	]	]	PUNCT
admet-782	134	4	and	and	CCONJ
admet-782	134	5	kim	kim	PROPN
admet-782	134	6	et	et	PROPN
admet-782	134	7	al	al	PROPN
admet-782	134	8	.	.	PUNCT
admet-782	135	1	[	[	X
admet-782	135	2	11	11	NUM
admet-782	135	3	]	]	PUNCT
admet-782	135	4	using	use	VERB
admet-782	135	5	digitizeit	digitizeit	NOUN
admet-782	135	6	software	software	NOUN
admet-782	135	7	[	[	X
admet-782	135	8	13	13	NUM
admet-782	135	9	]	]	PUNCT
admet-782	135	10	and	and	CCONJ
admet-782	135	11	found	find	VERB
admet-782	135	12	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	135	13	r.	r.	PROPN
admet-782	135	14	mullangi	mullangi	PROPN
admet-782	135	15	et	et	PROPN
admet-782	135	16	al	al	PROPN
admet-782	135	17	.	.	PROPN
admet-782	135	18	admet	admet	PROPN
admet-782	135	19	&	&	CCONJ
admet-782	135	20	dmpk	dmpk	PROPN
admet-782	135	21	8(1	8(1	NOUN
admet-782	135	22	)	)	PUNCT
admet-782	135	23	(	(	PUNCT
admet-782	135	24	2020	2020	NUM
admet-782	135	25	)	)	PUNCT
admet-782	135	26	113	113	NUM
admet-782	135	27	-	-	SYM
admet-782	135	28	121	121	NUM
admet-782	135	29	120	120	NUM
admet-782	135	30	that	that	SCONJ
admet-782	135	31	in	in	ADP
admet-782	135	32	both	both	DET
admet-782	135	33	studies	study	NOUN
admet-782	135	34	copanlisib	copanlisib	AUX
admet-782	135	35	showed	show	VERB
admet-782	135	36	~50	~50	ADP
admet-782	135	37	ng	ng	PROPN
admet-782	135	38	/	/	SYM
admet-782	135	39	ml	ml	NOUN
admet-782	135	40	till	till	SCONJ
admet-782	135	41	8	8	NUM
admet-782	135	42	h.	h.	NOUN
admet-782	135	43	by	by	ADP
admet-782	135	44	achieving	achieve	VERB
admet-782	135	45	50	50	NUM
admet-782	135	46	ng	ng	NOUN
admet-782	135	47	/	/	SYM
admet-782	135	48	ml	ml	NOUN
admet-782	135	49	sensitivity	sensitivity	NOUN
admet-782	135	50	for	for	ADP
admet-782	135	51	copanlisib	copanlisib	PROPN
admet-782	135	52	on	on	ADP
admet-782	135	53	hplc	hplc	NOUN
admet-782	135	54	-	-	PUNCT
admet-782	135	55	uv	uv	NOUN
admet-782	135	56	in	in	ADP
admet-782	135	57	the	the	DET
admet-782	135	58	present	present	ADJ
admet-782	135	59	method	method	NOUN
admet-782	135	60	,	,	PUNCT
admet-782	135	61	we	we	PRON
admet-782	135	62	believe	believe	VERB
admet-782	135	63	our	our	PRON
admet-782	135	64	present	present	ADJ
admet-782	135	65	method	method	NOUN
admet-782	135	66	can	can	AUX
admet-782	135	67	be	be	AUX
admet-782	135	68	reliably	reliably	ADV
admet-782	135	69	used	use	VERB
admet-782	135	70	in	in	ADP
admet-782	135	71	hospitals	hospital	NOUN
admet-782	135	72	for	for	ADP
admet-782	135	73	routine	routine	ADJ
admet-782	135	74	therapeutic	therapeutic	ADJ
admet-782	135	75	drug	drug	NOUN
admet-782	135	76	monitoring	monitoring	NOUN
admet-782	135	77	of	of	ADP
admet-782	135	78	copanlisib	copanlisib	PROPN
admet-782	135	79	.	.	PUNCT
admet-782	136	1	by	by	ADP
admet-782	136	2	increasing	increase	VERB
admet-782	136	3	the	the	DET
admet-782	136	4	plasma	plasma	NOUN
admet-782	136	5	volume	volume	NOUN
admet-782	136	6	for	for	ADP
admet-782	136	7	sample	sample	NOUN
admet-782	136	8	processing	processing	NOUN
admet-782	136	9	and	and	CCONJ
admet-782	136	10	injection	injection	NOUN
admet-782	136	11	volume	volume	NOUN
admet-782	136	12	for	for	ADP
admet-782	136	13	hplc	hplc	NOUN
admet-782	136	14	analysis	analysis	NOUN
admet-782	136	15	,	,	PUNCT
admet-782	136	16	there	there	PRON
admet-782	136	17	is	be	VERB
admet-782	136	18	a	a	DET
admet-782	136	19	great	great	ADJ
admet-782	136	20	possibility	possibility	NOUN
admet-782	136	21	that	that	SCONJ
admet-782	136	22	our	our	PRON
admet-782	136	23	validated	validate	VERB
admet-782	136	24	hplc	hplc	NOUN
admet-782	136	25	-	-	PUNCT
admet-782	136	26	uv	uv	NOUN
admet-782	136	27	can	can	AUX
admet-782	136	28	be	be	AUX
admet-782	136	29	used	use	VERB
admet-782	136	30	to	to	PART
admet-782	136	31	quantify	quantify	VERB
admet-782	136	32	the	the	DET
admet-782	136	33	copanlisib	copanlisib	PROPN
admet-782	136	34	plasma	plasma	NOUN
admet-782	136	35	concentration	concentration	NOUN
admet-782	136	36	at	at	ADP
admet-782	136	37	terminal	terminal	ADJ
admet-782	136	38	time	time	NOUN
admet-782	136	39	points	point	NOUN
admet-782	136	40	at	at	ADP
admet-782	136	41	therapeutic	therapeutic	ADJ
admet-782	136	42	doses	dose	NOUN
admet-782	136	43	.	.	PUNCT
admet-782	137	1	figure	figure	VERB
admet-782	137	2	4	4	NUM
admet-782	137	3	.	.	PUNCT
admet-782	138	1	mean	mean	VERB
admet-782	138	2	plasma	plasma	NOUN
admet-782	138	3	concentration	concentration	NOUN
admet-782	138	4	versus	versus	ADP
admet-782	138	5	time	time	NOUN
admet-782	138	6	profile	profile	NOUN
admet-782	138	7	for	for	ADP
admet-782	138	8	copanlisib	copanlisib	PROPN
admet-782	138	9	in	in	ADP
admet-782	138	10	mice	mice	NOUN
admet-782	138	11	plasma	plasma	NOUN
admet-782	138	12	following	follow	VERB
admet-782	138	13	intravenous	intravenous	ADJ
admet-782	138	14	administration	administration	NOUN
admet-782	138	15	to	to	ADP
admet-782	138	16	mice	mice	VERB
admet-782	138	17	.	.	PUNCT
admet-782	139	1	conclusions	conclusion	NOUN
admet-782	139	2	a	a	DET
admet-782	139	3	simple	simple	ADJ
admet-782	139	4	reversed	reverse	VERB
admet-782	139	5	-	-	PUNCT
admet-782	139	6	phase	phase	NOUN
admet-782	139	7	hplc	hplc	NOUN
admet-782	139	8	method	method	NOUN
admet-782	139	9	for	for	ADP
admet-782	139	10	determination	determination	NOUN
admet-782	139	11	of	of	ADP
admet-782	139	12	copanlisib	copanlisib	PROPN
admet-782	139	13	in	in	ADP
admet-782	139	14	mice	mice	NOUN
admet-782	139	15	plasma	plasma	NOUN
admet-782	139	16	has	have	AUX
admet-782	139	17	been	be	AUX
admet-782	139	18	developed	develop	VERB
admet-782	139	19	and	and	CCONJ
admet-782	139	20	validated	validate	VERB
admet-782	139	21	.	.	PUNCT
admet-782	140	1	the	the	DET
admet-782	140	2	proposed	propose	VERB
admet-782	140	3	method	method	NOUN
admet-782	140	4	is	be	AUX
admet-782	140	5	highly	highly	ADV
admet-782	140	6	specific	specific	ADJ
admet-782	140	7	,	,	PUNCT
admet-782	140	8	accurate	accurate	ADJ
admet-782	140	9	,	,	PUNCT
admet-782	140	10	precise	precise	ADJ
admet-782	140	11	and	and	CCONJ
admet-782	140	12	reproducible	reproducible	ADJ
admet-782	140	13	.	.	PUNCT
admet-782	141	1	all	all	DET
admet-782	141	2	the	the	DET
admet-782	141	3	validation	validation	NOUN
admet-782	141	4	parameters	parameter	NOUN
admet-782	141	5	were	be	AUX
admet-782	141	6	within	within	ADP
admet-782	141	7	the	the	DET
admet-782	141	8	acceptable	acceptable	ADJ
admet-782	141	9	limits	limit	NOUN
admet-782	141	10	for	for	ADP
admet-782	141	11	a	a	DET
admet-782	141	12	bioanalytical	bioanalytical	ADJ
admet-782	141	13	method	method	NOUN
admet-782	141	14	as	as	ADP
admet-782	141	15	per	per	ADP
admet-782	141	16	regulatory	regulatory	ADJ
admet-782	141	17	guideline	guideline	NOUN
admet-782	141	18	.	.	PUNCT
admet-782	142	1	this	this	DET
admet-782	142	2	method	method	NOUN
admet-782	142	3	has	have	AUX
admet-782	142	4	been	be	AUX
admet-782	142	5	successfully	successfully	ADV
admet-782	142	6	applied	apply	VERB
admet-782	142	7	to	to	ADP
admet-782	142	8	a	a	DET
admet-782	142	9	pharmacokinetic	pharmacokinetic	ADJ
admet-782	142	10	study	study	NOUN
admet-782	142	11	in	in	ADP
admet-782	142	12	mice	mouse	NOUN
admet-782	142	13	.	.	PUNCT
admet-782	143	1	conflict	conflict	NOUN
admet-782	143	2	of	of	ADP
admet-782	143	3	interest	interest	NOUN
admet-782	143	4	:	:	PUNCT
admet-782	143	5	the	the	DET
admet-782	143	6	authors	author	NOUN
admet-782	143	7	are	be	AUX
admet-782	143	8	scientists	scientist	NOUN
admet-782	143	9	at	at	ADP
admet-782	143	10	jubilant	jubilant	PROPN
admet-782	143	11	biosys	biosys	PROPN
admet-782	143	12	ltd	ltd	PROPN
admet-782	143	13	.	.	PROPN
admet-782	143	14	references	reference	NOUN
admet-782	144	1	[	[	X
admet-782	144	2	1	1	NUM
admet-782	144	3	]	]	X
admet-782	144	4	l.c	l.c	PROPN
admet-782	144	5	.	.	PROPN
admet-782	144	6	cantley	cantley	PROPN
admet-782	144	7	.	.	PUNCT
admet-782	145	1	the	the	DET
admet-782	145	2	phosphoinositide	phosphoinositide	ADJ
admet-782	145	3	3	3	NUM
admet-782	145	4	-	-	PUNCT
admet-782	145	5	kinase	kinase	NOUN
admet-782	145	6	pathway	pathway	NOUN
admet-782	145	7	.	.	PUNCT
admet-782	146	1	science	science	NOUN
admet-782	146	2	296	296	NUM
admet-782	146	3	(	(	PUNCT
admet-782	146	4	2002	2002	NUM
admet-782	146	5	)	)	PUNCT
admet-782	146	6	1655	1655	NUM
admet-782	146	7	-	-	SYM
admet-782	146	8	1657	1657	NUM
admet-782	146	9	.	.	PUNCT
admet-782	147	1	[	[	X
admet-782	147	2	2	2	NUM
admet-782	147	3	]	]	X
admet-782	147	4	t.l	t.l	PROPN
admet-782	147	5	.	.	PUNCT
admet-782	147	6	yuan	yuan	PROPN
admet-782	147	7	,	,	PUNCT
admet-782	147	8	l.c	l.c	PROPN
admet-782	147	9	.	.	PROPN
admet-782	147	10	cantley	cantley	PROPN
admet-782	147	11	.	.	PUNCT
admet-782	148	1	pi3k	pi3k	NOUN
admet-782	148	2	pathway	pathway	NOUN
admet-782	148	3	alterations	alteration	NOUN
admet-782	148	4	in	in	ADP
admet-782	148	5	cancer	cancer	NOUN
admet-782	148	6	:	:	PUNCT
admet-782	148	7	variations	variation	NOUN
admet-782	148	8	on	on	ADP
admet-782	148	9	a	a	DET
admet-782	148	10	theme	theme	NOUN
admet-782	148	11	.	.	PUNCT
admet-782	149	1	oncogene	oncogene	NOUN
admet-782	149	2	27	27	NUM
admet-782	149	3	(	(	PUNCT
admet-782	149	4	2008	2008	NUM
admet-782	149	5	)	)	PUNCT
admet-782	149	6	5497	5497	NUM
admet-782	149	7	-	-	SYM
admet-782	149	8	5510	5510	NUM
admet-782	149	9	.	.	PUNCT
admet-782	150	1	[	[	X
admet-782	150	2	3	3	NUM
admet-782	150	3	]	]	X
admet-782	150	4	k.d	k.d	PROPN
admet-782	150	5	.	.	PROPN
admet-782	150	6	courtney	courtney	PROPN
admet-782	150	7	,	,	PUNCT
admet-782	150	8	r.b	r.b	PROPN
admet-782	150	9	.	.	PROPN
admet-782	150	10	corcoran	corcoran	PROPN
admet-782	150	11	,	,	PUNCT
admet-782	150	12	j.a	j.a	PROPN
admet-782	150	13	.	.	PROPN
admet-782	150	14	engelman	engelman	PROPN
admet-782	150	15	.	.	PUNCT
admet-782	151	1	the	the	DET
admet-782	151	2	pi3k	pi3k	PROPN
admet-782	151	3	pathway	pathway	NOUN
admet-782	151	4	as	as	ADP
admet-782	151	5	drug	drug	NOUN
admet-782	151	6	target	target	NOUN
admet-782	151	7	in	in	ADP
admet-782	151	8	human	human	ADJ
admet-782	151	9	cancer	cancer	NOUN
admet-782	151	10	.	.	PUNCT
admet-782	152	1	journal	journal	NOUN
admet-782	152	2	of	of	ADP
admet-782	152	3	clinical	clinical	ADJ
admet-782	152	4	oncology	oncology	NOUN
admet-782	152	5	28	28	NUM
admet-782	152	6	(	(	PUNCT
admet-782	152	7	2010	2010	NUM
admet-782	152	8	)	)	PUNCT
admet-782	152	9	1075	1075	NUM
admet-782	152	10	-	-	SYM
admet-782	152	11	1083	1083	NUM
admet-782	152	12	.	.	PUNCT
admet-782	153	1	[	[	X
admet-782	153	2	4	4	X
admet-782	153	3	]	]	X
admet-782	153	4	j.e	j.e	PROPN
admet-782	153	5	.	.	PROPN
admet-782	153	6	kurtz	kurtz	PROPN
admet-782	153	7	,	,	PUNCT
admet-782	153	8	i.	i.	PROPN
admet-782	153	9	ray	ray	PROPN
admet-782	153	10	-	-	PUNCT
admet-782	153	11	coquard	coquard	NOUN
admet-782	153	12	.	.	PUNCT
admet-782	154	1	pi3	pi3	NOUN
admet-782	154	2	kinase	kinase	NOUN
admet-782	154	3	inhibitors	inhibitor	NOUN
admet-782	154	4	in	in	ADP
admet-782	154	5	the	the	DET
admet-782	154	6	clinic	clinic	NOUN
admet-782	154	7	:	:	PUNCT
admet-782	154	8	an	an	DET
admet-782	154	9	update	update	NOUN
admet-782	154	10	.	.	PUNCT
admet-782	155	1	anticancer	anticancer	NOUN
admet-782	155	2	research	research	NOUN
admet-782	155	3	32	32	NUM
admet-782	155	4	(	(	PUNCT
admet-782	155	5	2012	2012	NUM
admet-782	155	6	)	)	PUNCT
admet-782	155	7	2463	2463	NUM
admet-782	155	8	-	-	SYM
admet-782	155	9	2470	2470	NUM
admet-782	155	10	.	.	PUNCT
admet-782	156	1	[	[	X
admet-782	156	2	5	5	X
admet-782	156	3	]	]	PUNCT
admet-782	156	4	b.	b.	PROPN
admet-782	156	5	markman	markman	PROPN
admet-782	156	6	,	,	PUNCT
admet-782	156	7	j.j	j.j	PROPN
admet-782	156	8	.	.	PROPN
admet-782	156	9	tao	tao	PROPN
admet-782	156	10	,	,	PUNCT
admet-782	156	11	m.	m.	NOUN
admet-782	156	12	scaltriti	scaltriti	NOUN
admet-782	156	13	.	.	PUNCT
admet-782	157	1	pi3k	pi3k	NOUN
admet-782	157	2	pathway	pathway	NOUN
admet-782	157	3	inhibitors	inhibitor	NOUN
admet-782	157	4	:	:	PUNCT
admet-782	157	5	better	well	ADJ
admet-782	157	6	not	not	PART
admet-782	157	7	left	leave	VERB
admet-782	157	8	alone	alone	ADV
admet-782	157	9	.	.	PUNCT
admet-782	158	1	current	current	ADJ
admet-782	158	2	pharmaceutical	pharmaceutical	NOUN
admet-782	158	3	design	design	NOUN
admet-782	158	4	19	19	NUM
admet-782	158	5	(	(	PUNCT
admet-782	158	6	2013	2013	NUM
admet-782	158	7	)	)	PUNCT
admet-782	158	8	895	895	NUM
admet-782	158	9	-	-	SYM
admet-782	158	10	906	906	NUM
admet-782	158	11	.	.	PUNCT
admet-782	159	1	[	[	X
admet-782	159	2	6	6	NUM
admet-782	159	3	]	]	X
admet-782	159	4	b.l	b.l	PROPN
admet-782	159	5	.	.	PROPN
admet-782	159	6	lampson	lampson	PROPN
admet-782	159	7	,	,	PUNCT
admet-782	159	8	j.r	j.r	PROPN
admet-782	159	9	.	.	PROPN
admet-782	159	10	brown	brown	PROPN
admet-782	159	11	.	.	PUNCT
admet-782	160	1	pi3kδ	pi3kδ	NOUN
admet-782	160	2	-	-	PUNCT
admet-782	160	3	selective	selective	ADJ
admet-782	160	4	and	and	CCONJ
admet-782	160	5	pi3kα	pi3kα	NUM
admet-782	160	6	/	/	SYM
admet-782	160	7	δ	δ	NOUN
admet-782	160	8	-	-	NOUN
admet-782	160	9	combinatorial	combinatorial	ADJ
admet-782	160	10	inhibitors	inhibitor	NOUN
admet-782	160	11	in	in	ADP
admet-782	160	12	clinical	clinical	ADJ
admet-782	160	13	development	development	NOUN
admet-782	160	14	for	for	ADP
admet-782	160	15	b	b	NOUN
admet-782	160	16	-	-	PUNCT
admet-782	160	17	cell	cell	NOUN
admet-782	160	18	non	non	ADJ
admet-782	160	19	-	-	ADJ
admet-782	160	20	hodgkin	hodgkin	ADJ
admet-782	160	21	lymphoma	lymphoma	NOUN
admet-782	160	22	.	.	PUNCT
admet-782	161	1	expert	expert	ADJ
admet-782	161	2	opinion	opinion	NOUN
admet-782	161	3	on	on	ADP
admet-782	161	4	investigational	investigational	ADJ
admet-782	161	5	drugs	drug	NOUN
admet-782	161	6	26	26	NUM
admet-782	161	7	(	(	PUNCT
admet-782	161	8	2017	2017	NUM
admet-782	161	9	)	)	PUNCT
admet-782	161	10	1267	1267	NUM
admet-782	161	11	-	-	SYM
admet-782	161	12	1279	1279	NUM
admet-782	161	13	.	.	PUNCT
admet-782	162	1	[	[	X
admet-782	162	2	7	7	X
admet-782	162	3	]	]	X
admet-782	162	4	n.	n.	PROPN
admet-782	162	5	liu	liu	PROPN
admet-782	162	6	,	,	PUNCT
admet-782	162	7	b.r	b.r	PROPN
admet-782	162	8	.	.	PROPN
admet-782	162	9	rowley	rowley	PROPN
admet-782	162	10	,	,	PUNCT
admet-782	162	11	c.o	c.o	PROPN
admet-782	162	12	.	.	PROPN
admet-782	162	13	bull	bull	PROPN
admet-782	162	14	,	,	PUNCT
admet-782	162	15	c.	c.	PROPN
admet-782	162	16	schneider	schneider	PROPN
admet-782	162	17	,	,	PUNCT
admet-782	162	18	a.	a.	NOUN
admet-782	162	19	haegebarth	haegebarth	NOUN
admet-782	162	20	,	,	PUNCT
admet-782	162	21	c.a	c.a	PROPN
admet-782	162	22	.	.	PROPN
admet-782	162	23	schatz	schatz	PROPN
admet-782	162	24	,	,	PUNCT
admet-782	162	25	p.r	p.r	PROPN
admet-782	162	26	.	.	PROPN
admet-782	162	27	fracasso	fracasso	PROPN
admet-782	162	28	,	,	PUNCT
admet-782	162	29	d.p	d.p	PROPN
admet-782	162	30	.	.	PROPN
admet-782	162	31	wilkie	wilkie	PROPN
admet-782	162	32	,	,	PUNCT
admet-782	162	33	m.	m.	NOUN
admet-782	162	34	hentemann	hentemann	PROPN
admet-782	162	35	,	,	PUNCT
admet-782	162	36	s.m	s.m	PROPN
admet-782	162	37	.	.	PROPN
admet-782	162	38	wilhelm	wilhelm	PROPN
admet-782	162	39	,	,	PUNCT
admet-782	162	40	w.j	w.j	PROPN
admet-782	162	41	.	.	PROPN
admet-782	162	42	scott	scott	PROPN
admet-782	162	43	,	,	PUNCT
admet-782	162	44	d.	d.	PROPN
admet-782	162	45	mumberg	mumberg	PROPN
admet-782	162	46	,	,	PUNCT
admet-782	162	47	k.	k.	PROPN
admet-782	162	48	ziegelbauer	ziegelbauer	PROPN
admet-782	162	49	.	.	PUNCT
admet-782	163	1	bay	bay	PROPN
admet-782	163	2	80	80	NUM
admet-782	163	3	-	-	SYM
admet-782	163	4	6946	6946	NUM
admet-782	163	5	is	be	AUX
admet-782	163	6	a	a	DET
admet-782	163	7	highly	highly	ADV
admet-782	163	8	selective	selective	ADJ
admet-782	163	9	intravenous	intravenous	ADJ
admet-782	163	10	pi3k	pi3k	NOUN
admet-782	163	11	inhibitor	inhibitor	NOUN
admet-782	163	12	with	with	ADP
admet-782	163	13	potent	potent	ADJ
admet-782	163	14	p110α	p110α	PROPN
admet-782	163	15	and	and	CCONJ
admet-782	163	16	p110δ	p110δ	ADJ
admet-782	163	17	activities	activity	NOUN
admet-782	163	18	in	in	ADP
admet-782	163	19	tumor	tumor	NOUN
admet-782	163	20	cell	cell	NOUN
admet-782	163	21	lines	line	NOUN
admet-782	163	22	and	and	CCONJ
admet-782	163	23	xenograft	xenograft	NOUN
admet-782	163	24	models	model	NOUN
admet-782	163	25	.	.	PUNCT
admet-782	164	1	molecular	molecular	ADJ
admet-782	164	2	cancer	cancer	NOUN
admet-782	164	3	therapeutics	therapeutic	NOUN
admet-782	164	4	12	12	NUM
admet-782	164	5	(	(	PUNCT
admet-782	164	6	2013	2013	NUM
admet-782	164	7	)	)	PUNCT
admet-782	164	8	2319	2319	NUM
admet-782	164	9	-	-	SYM
admet-782	164	10	2330	2330	NUM
admet-782	164	11	.	.	PUNCT
admet-782	165	1	[	[	X
admet-782	165	2	8	8	NUM
admet-782	165	3	]	]	PUNCT
admet-782	165	4	aliqopatm	aliqopatm	NOUN
admet-782	165	5	.	.	PUNCT
admet-782	166	1	aliqopa	aliqopa	PROPN
admet-782	166	2	(	(	PUNCT
admet-782	166	3	copanlisib	copanlisib	PROPN
admet-782	166	4	)	)	PUNCT
admet-782	166	5	injection	injection	NOUN
admet-782	167	1	[	[	X
admet-782	167	2	prescribing	prescribe	VERB
admet-782	167	3	information	information	NOUN
admet-782	167	4	]	]	PUNCT
admet-782	167	5	.	.	PUNCT
admet-782	168	1	whippany	whippany	PROPN
admet-782	168	2	,	,	PUNCT
admet-782	168	3	nj	nj	PROPN
admet-782	168	4	:	:	PUNCT
admet-782	168	5	bayer	bayer	PROPN
admet-782	168	6	healthcare	healthcare	PROPN
admet-782	168	7	pharmaceuticals	pharmaceuticals	PROPN
admet-782	168	8	inc	inc	PROPN
admet-782	168	9	.	.	PROPN
admet-782	168	10	;	;	PUNCT
admet-782	168	11	september	september	PROPN
admet-782	168	12	2017	2017	NUM
admet-782	168	13	.	.	PUNCT
admet-782	169	1	admet	admet	PROPN
admet-782	169	2	&	&	CCONJ
admet-782	169	3	dmpk	dmpk	PROPN
admet-782	169	4	8(1	8(1	NOUN
admet-782	169	5	)	)	PUNCT
admet-782	169	6	(	(	PUNCT
admet-782	169	7	2020	2020	NUM
admet-782	169	8	)	)	PUNCT
admet-782	169	9	113	113	NUM
admet-782	169	10	-	-	SYM
admet-782	169	11	121	121	NUM
admet-782	169	12	copanlisib	copanlisib	NOUN
admet-782	169	13	quantification	quantification	NOUN
admet-782	169	14	by	by	ADP
admet-782	169	15	hplc	hplc	NOUN
admet-782	169	16	in	in	ADP
admet-782	169	17	mice	mice	NOUN
admet-782	169	18	plasma	plasma	NOUN
admet-782	169	19	doi	doi	PROPN
admet-782	169	20	:	:	PUNCT
admet-782	169	21	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	PROPN
admet-782	169	22	121	121	NUM
admet-782	169	23	[	[	X
admet-782	169	24	9	9	NUM
admet-782	169	25	]	]	PUNCT
admet-782	169	26	s.	s.	PROPN
admet-782	169	27	dittakavi	dittakavi	PROPN
admet-782	169	28	,	,	PUNCT
admet-782	169	29	r.	r.	PROPN
admet-782	169	30	mullangi	mullangi	PROPN
admet-782	169	31	.	.	PUNCT
admet-782	170	1	lc	lc	PROPN
admet-782	170	2	-	-	PUNCT
admet-782	170	3	esi	esi	PROPN
admet-782	170	4	-	-	PUNCT
admet-782	170	5	ms	ms	ADJ
admet-782	170	6	/	/	SYM
admet-782	170	7	ms	ms	NOUN
admet-782	170	8	determination	determination	NOUN
admet-782	170	9	of	of	ADP
admet-782	170	10	copanlisib	copanlisib	PROPN
admet-782	170	11	,	,	PUNCT
admet-782	170	12	a	a	DET
admet-782	170	13	novel	novel	ADJ
admet-782	170	14	pi3k	pi3k	NOUN
admet-782	170	15	inhibitor	inhibitor	NOUN
admet-782	170	16	in	in	ADP
admet-782	170	17	mouse	mouse	NOUN
admet-782	170	18	plasma	plasma	NOUN
admet-782	170	19	and	and	CCONJ
admet-782	170	20	its	its	PRON
admet-782	170	21	application	application	NOUN
admet-782	170	22	to	to	ADP
admet-782	170	23	a	a	DET
admet-782	170	24	pharmacokinetic	pharmacokinetic	ADJ
admet-782	170	25	study	study	NOUN
admet-782	170	26	in	in	ADP
admet-782	170	27	mice	mouse	NOUN
admet-782	170	28	.	.	PUNCT
admet-782	171	1	biomedical	biomedical	ADJ
admet-782	171	2	chromatography	chromatography	NOUN
admet-782	171	3	33	33	NUM
admet-782	171	4	(	(	PUNCT
admet-782	171	5	2019	2019	NUM
admet-782	171	6	)	)	PUNCT
admet-782	171	7	e4460	e4460	NOUN
admet-782	171	8	.	.	PUNCT
admet-782	172	1	[	[	X
admet-782	172	2	10	10	NUM
admet-782	172	3	]	]	PUNCT
admet-782	172	4	a.	a.	NOUN
admet-782	172	5	patnaik	patnaik	PROPN
admet-782	172	6	,	,	PUNCT
admet-782	172	7	l.j	l.j	PROPN
admet-782	172	8	.	.	PROPN
admet-782	172	9	appleman	appleman	PROPN
admet-782	172	10	,	,	PUNCT
admet-782	172	11	a.w	a.w	PROPN
admet-782	172	12	.	.	PROPN
admet-782	172	13	tolcher	tolcher	PROPN
admet-782	172	14	,	,	PUNCT
admet-782	172	15	k.p	k.p	PROPN
admet-782	172	16	.	.	PROPN
admet-782	172	17	papadopoulos	papadopoulos	PROPN
admet-782	172	18	,	,	PUNCT
admet-782	172	19	m.	m.	NOUN
admet-782	172	20	beeram	beeram	NOUN
admet-782	172	21	,	,	PUNCT
admet-782	172	22	d.w	d.w	PROPN
admet-782	172	23	.	.	PROPN
admet-782	172	24	rasco	rasco	PROPN
admet-782	172	25	,	,	PUNCT
admet-782	172	26	g.j	g.j	PROPN
admet-782	172	27	.	.	PROPN
admet-782	172	28	weiss	weiss	PROPN
admet-782	172	29	,	,	PUNCT
admet-782	172	30	j.c	j.c	PROPN
admet-782	172	31	.	.	PROPN
admet-782	172	32	sachdev	sachdev	PROPN
admet-782	172	33	,	,	PUNCT
admet-782	172	34	m.	m.	NOUN
admet-782	172	35	chadha	chadha	PROPN
admet-782	172	36	,	,	PUNCT
admet-782	172	37	m.	m.	NOUN
admet-782	172	38	fulk	fulk	PROPN
admet-782	172	39	,	,	PUNCT
admet-782	172	40	s.	s.	PROPN
admet-782	172	41	ejadi	ejadi	PROPN
admet-782	172	42	,	,	PUNCT
admet-782	172	43	j.m	j.m	PROPN
admet-782	172	44	.	.	PROPN
admet-782	172	45	mountz	mountz	PROPN
admet-782	172	46	,	,	PUNCT
admet-782	172	47	m.t	m.t	PROPN
admet-782	172	48	.	.	PROPN
admet-782	172	49	lotze	lotze	PROPN
admet-782	172	50	,	,	PUNCT
admet-782	172	51	f.g.s	f.g.s	PROPN
admet-782	172	52	.	.	PROPN
admet-782	172	53	toledo	toledo	PROPN
admet-782	172	54	,	,	PUNCT
admet-782	172	55	e.	e.	PROPN
admet-782	172	56	chu	chu	PROPN
admet-782	172	57	,	,	PUNCT
admet-782	172	58	m.	m.	NOUN
admet-782	172	59	jeffers	jeffers	PROPN
admet-782	172	60	,	,	PUNCT
admet-782	172	61	c.	c.	PROPN
admet-782	172	62	peña	peña	PROPN
admet-782	172	63	,	,	PUNCT
admet-782	172	64	c.	c.	PROPN
admet-782	172	65	xia	xia	PROPN
admet-782	172	66	,	,	PUNCT
admet-782	172	67	s.	s.	PROPN
admet-782	172	68	reif	reif	PROPN
admet-782	172	69	,	,	PUNCT
admet-782	172	70	i.	i.	PROPN
admet-782	172	71	genvresse	genvresse	PROPN
admet-782	172	72	,	,	PUNCT
admet-782	172	73	r.k	r.k	PROPN
admet-782	172	74	.	.	PROPN
admet-782	172	75	ramanathan	ramanathan	PROPN
admet-782	172	76	.	.	PUNCT
admet-782	173	1	first	first	ADJ
admet-782	173	2	-	-	PUNCT
admet-782	173	3	in	in	ADP
admet-782	173	4	-	-	PUNCT
admet-782	173	5	human	human	ADJ
admet-782	173	6	phase	phase	NOUN
admet-782	173	7	i	i	PRON
admet-782	173	8	study	study	VERB
admet-782	173	9	of	of	ADP
admet-782	173	10	copanlisib	copanlisib	PROPN
admet-782	173	11	(	(	PUNCT
admet-782	173	12	bay	bay	NOUN
admet-782	173	13	80	80	NUM
admet-782	173	14	-	-	PUNCT
admet-782	173	15	6946	6946	NUM
admet-782	173	16	)	)	PUNCT
admet-782	173	17	,	,	PUNCT
admet-782	173	18	an	an	DET
admet-782	173	19	intravenous	intravenous	ADJ
admet-782	173	20	pan	pan	NOUN
admet-782	173	21	-	-	NOUN
admet-782	173	22	class	class	NOUN
admet-782	173	23	i	i	PRON
admet-782	173	24	phosphatidylinositol	phosphatidylinositol	VERB
admet-782	173	25	3	3	NUM
admet-782	173	26	-	-	PUNCT
admet-782	173	27	kinase	kinase	NOUN
admet-782	173	28	inhibitor	inhibitor	NOUN
admet-782	173	29	,	,	PUNCT
admet-782	173	30	in	in	ADP
admet-782	173	31	patients	patient	NOUN
admet-782	173	32	with	with	ADP
admet-782	173	33	advanced	advanced	ADJ
admet-782	173	34	solid	solid	ADJ
admet-782	173	35	tumors	tumor	NOUN
admet-782	173	36	and	and	CCONJ
admet-782	173	37	non	non	ADJ
admet-782	173	38	-	-	ADJ
admet-782	173	39	hodgkin	hodgkin	ADJ
admet-782	173	40	’s	’s	PART
admet-782	173	41	lymphomas	lymphoma	NOUN
admet-782	173	42	.	.	PUNCT
admet-782	174	1	annals	annal	NOUN
admet-782	174	2	of	of	ADP
admet-782	174	3	oncology	oncology	NOUN
admet-782	174	4	27	27	NUM
admet-782	174	5	(	(	PUNCT
admet-782	174	6	2016	2016	NUM
admet-782	174	7	)	)	PUNCT
admet-782	174	8	1928	1928	NUM
admet-782	174	9	-	-	SYM
admet-782	174	10	1940	1940	NUM
admet-782	174	11	.	.	PUNCT
admet-782	175	1	[	[	X
admet-782	175	2	11	11	NUM
admet-782	175	3	]	]	X
admet-782	175	4	r.d	r.d	PROPN
admet-782	175	5	.	.	PROPN
admet-782	175	6	kim	kim	PROPN
admet-782	175	7	,	,	PUNCT
admet-782	175	8	s.r	s.r	PROPN
admet-782	175	9	.	.	PROPN
admet-782	175	10	alberts	alberts	PROPN
admet-782	175	11	,	,	PUNCT
admet-782	175	12	c.	c.	PROPN
admet-782	175	13	peña	peña	PROPN
admet-782	175	14	,	,	PUNCT
admet-782	175	15	i.	i.	PROPN
admet-782	175	16	genvresse	genvresse	PROPN
admet-782	175	17	,	,	PUNCT
admet-782	175	18	a.	a.	PROPN
admet-782	175	19	ajavon	ajavon	PROPN
admet-782	175	20	-	-	PUNCT
admet-782	175	21	hartman4	hartman4	PROPN
admet-782	175	22	,	,	PUNCT
admet-782	175	23	c.	c.	PROPN
admet-782	175	24	xia	xia	PROPN
admet-782	175	25	,	,	PUNCT
admet-782	175	26	a.	a.	PROPN
admet-782	175	27	kelly	kelly	PROPN
admet-782	175	28	,	,	PUNCT
admet-782	175	29	j.e	j.e	PROPN
admet-782	175	30	.	.	PROPN
admet-782	175	31	grilley	grilley	PROPN
admet-782	175	32	-	-	PUNCT
admet-782	175	33	olson	olson	NOUN
admet-782	175	34	.	.	PUNCT
admet-782	175	35	phase	phase	NOUN
admet-782	175	36	i	i	PRON
admet-782	175	37	dose	dose	NOUN
admet-782	175	38	-	-	PUNCT
admet-782	175	39	escalation	escalation	NOUN
admet-782	175	40	study	study	NOUN
admet-782	175	41	of	of	ADP
admet-782	175	42	copanlisib	copanlisib	PROPN
admet-782	175	43	in	in	ADP
admet-782	175	44	combination	combination	NOUN
admet-782	175	45	with	with	ADP
admet-782	175	46	gemcitabine	gemcitabine	NOUN
admet-782	175	47	or	or	CCONJ
admet-782	175	48	cisplatin	cisplatin	NOUN
admet-782	175	49	plus	plus	CCONJ
admet-782	175	50	gemcitabine	gemcitabine	NOUN
admet-782	175	51	in	in	ADP
admet-782	175	52	patients	patient	NOUN
admet-782	175	53	with	with	ADP
admet-782	175	54	advanced	advanced	ADJ
admet-782	175	55	cancer	cancer	NOUN
admet-782	175	56	.	.	PUNCT
admet-782	176	1	british	british	ADJ
admet-782	176	2	journal	journal	PROPN
admet-782	176	3	of	of	ADP
admet-782	176	4	cancer	cancer	NOUN
admet-782	176	5	118	118	NUM
admet-782	176	6	(	(	PUNCT
admet-782	176	7	2018	2018	NUM
admet-782	176	8	)	)	PUNCT
admet-782	176	9	462	462	NUM
admet-782	176	10	-	-	SYM
admet-782	176	11	470	470	NUM
admet-782	176	12	.	.	PUNCT
admet-782	177	1	[	[	X
admet-782	177	2	12	12	NUM
admet-782	177	3	]	]	PUNCT
admet-782	177	4	us	us	PROPN
admet-782	177	5	dhhs	dhhs	PROPN
admet-782	177	6	,	,	PUNCT
admet-782	177	7	fda	fda	PROPN
admet-782	177	8	,	,	PUNCT
admet-782	177	9	cder	cder	NOUN
admet-782	177	10	,	,	PUNCT
admet-782	177	11	cvm	cvm	PROPN
admet-782	177	12	,	,	PUNCT
admet-782	177	13	guidance	guidance	NOUN
admet-782	177	14	for	for	ADP
admet-782	177	15	industry	industry	NOUN
admet-782	177	16	:	:	PUNCT
admet-782	177	17	bioanalytical	bioanalytical	ADJ
admet-782	177	18	method	method	NOUN
admet-782	177	19	validation	validation	NOUN
admet-782	177	20	,	,	PUNCT
admet-782	177	21	u.s	u.s	PROPN
admet-782	177	22	.	.	PROPN
admet-782	177	23	department	department	PROPN
admet-782	177	24	of	of	ADP
admet-782	177	25	health	health	PROPN
admet-782	177	26	and	and	CCONJ
admet-782	177	27	human	human	ADJ
admet-782	177	28	services	service	NOUN
admet-782	177	29	,	,	PUNCT
admet-782	177	30	food	food	NOUN
admet-782	177	31	and	and	CCONJ
admet-782	177	32	drug	drug	NOUN
admet-782	177	33	administration	administration	NOUN
admet-782	177	34	,	,	PUNCT
admet-782	177	35	center	center	NOUN
admet-782	177	36	for	for	ADP
admet-782	177	37	drug	drug	NOUN
admet-782	177	38	evaluation	evaluation	NOUN
admet-782	177	39	and	and	CCONJ
admet-782	177	40	research	research	NOUN
admet-782	177	41	(	(	PUNCT
admet-782	177	42	cder	cder	NOUN
admet-782	177	43	)	)	PUNCT
admet-782	177	44	,	,	PUNCT
admet-782	177	45	center	center	NOUN
admet-782	177	46	for	for	ADP
admet-782	177	47	veterinary	veterinary	ADJ
admet-782	177	48	medicine	medicine	NOUN
admet-782	177	49	(	(	PUNCT
admet-782	177	50	cv	cv	PROPN
admet-782	177	51	)	)	PUNCT
admet-782	177	52	,	,	PUNCT
admet-782	177	53	(	(	PUNCT
admet-782	177	54	2018	2018	NUM
admet-782	177	55	)	)	PUNCT
admet-782	177	56	,	,	PUNCT
admet-782	177	57	rockville	rockville	PROPN
admet-782	177	58	,	,	PUNCT
admet-782	177	59	md	md	PROPN
admet-782	177	60	,	,	PUNCT
admet-782	177	61	usa	usa	PROPN
admet-782	177	62	.	.	PUNCT
admet-782	178	1	[	[	X
admet-782	178	2	13	13	NUM
admet-782	178	3	]	]	PUNCT
admet-782	178	4	https://www.digitizeit.de	https://www.digitizeit.de	DET
admet-782	178	5	version	version	NOUN
admet-782	178	6	2.0.0	2.0.0	NUM
admet-782	178	7	;	;	PUNCT
admet-782	178	8	accessed	access	VERB
admet-782	178	9	on	on	ADP
admet-782	178	10	10	10	NUM
admet-782	178	11	january	january	NOUN
admet-782	178	12	2020	2020	NUM
admet-782	178	13	.	.	PUNCT
admet-782	179	1	©	©	PROPN
admet-782	179	2	2020	2020	NUM
admet-782	179	3	by	by	ADP
admet-782	179	4	the	the	DET
admet-782	179	5	authors	author	NOUN
admet-782	179	6	;	;	PUNCT
admet-782	179	7	licensee	licensee	PROPN
admet-782	179	8	iapc	iapc	PROPN
admet-782	179	9	,	,	PUNCT
admet-782	179	10	zagreb	zagreb	PROPN
admet-782	179	11	,	,	PUNCT
admet-782	179	12	croatia	croatia	PROPN
admet-782	179	13	.	.	PUNCT
admet-782	180	1	this	this	DET
admet-782	180	2	article	article	NOUN
admet-782	180	3	is	be	AUX
admet-782	180	4	an	an	DET
admet-782	180	5	open	open	ADJ
admet-782	180	6	-	-	PUNCT
admet-782	180	7	access	access	NOUN
admet-782	180	8	article	article	NOUN
admet-782	180	9	distributed	distribute	VERB
admet-782	180	10	under	under	ADP
admet-782	180	11	the	the	DET
admet-782	180	12	terms	term	NOUN
admet-782	180	13	and	and	CCONJ
admet-782	180	14	conditions	condition	NOUN
admet-782	180	15	of	of	ADP
admet-782	180	16	the	the	DET
admet-782	180	17	creative	creative	ADJ
admet-782	180	18	commons	common	NOUN
admet-782	180	19	attribution	attribution	NOUN
admet-782	180	20	license	license	NOUN
admet-782	180	21	(	(	PUNCT
admet-782	180	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-782	180	23	)	)	PUNCT
admet-782	180	24	http://dx.doi.org/10.5599/admet.782	http://dx.doi.org/10.5599/admet.782	NOUN
admet-782	180	25	https://www.digitizeit.de/	https://www.digitizeit.de/	X
admet-782	180	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN