id	sid	tid	token	lemma	pos
admet-796	1	1	validated	validate	VERB
admet-796	1	2	dbs	dbs	NOUN
admet-796	1	3	method	method	NOUN
admet-796	1	4	for	for	ADP
admet-796	1	5	filgotinib	filgotinib	ADJ
admet-796	1	6	quantitation	quantitation	NOUN
admet-796	1	7	in	in	ADP
admet-796	1	8	rat	rat	NOUN
admet-796	1	9	dried	dry	VERB
admet-796	1	10	blood	blood	NOUN
admet-796	1	11	spots	spot	NOUN
admet-796	1	12	and	and	CCONJ
admet-796	1	13	its	its	PRON
admet-796	1	14	application	application	NOUN
admet-796	1	15	to	to	ADP
admet-796	1	16	a	a	DET
admet-796	1	17	pharmacokinetic	pharmacokinetic	ADJ
admet-796	1	18	study	study	NOUN
admet-796	1	19	in	in	ADP
admet-796	1	20	rats	rat	NOUN
admet-796	1	21	doi	doi	NOUN
admet-796	1	22	:	:	PUNCT
admet-796	1	23	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PROPN
admet-796	1	24	139	139	NUM
admet-796	1	25	admet	admet	PROPN
admet-796	1	26	&	&	CCONJ
admet-796	1	27	dmpk	dmpk	PROPN
admet-796	1	28	8(2	8(2	NUM
admet-796	1	29	)	)	PUNCT
admet-796	1	30	(	(	PUNCT
admet-796	1	31	2020	2020	NUM
admet-796	1	32	)	)	PUNCT
admet-796	1	33	139	139	NUM
admet-796	1	34	-	-	SYM
admet-796	1	35	148	148	NUM
admet-796	1	36	;	;	PUNCT
admet-796	1	37	doi	doi	NOUN
admet-796	1	38	:	:	PUNCT
admet-796	1	39	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	X
admet-796	1	40	open	open	ADJ
admet-796	1	41	access	access	NOUN
admet-796	1	42	:	:	PUNCT
admet-796	1	43	issn	issn	PROPN
admet-796	1	44	:	:	PUNCT
admet-796	1	45	1848	1848	NUM
admet-796	1	46	-	-	SYM
admet-796	1	47	7718	7718	NUM
admet-796	1	48	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-796	1	49	original	original	ADJ
admet-796	1	50	scientific	scientific	ADJ
admet-796	1	51	paper	paper	NOUN
admet-796	1	52	validated	validate	VERB
admet-796	1	53	dbs	dbs	NOUN
admet-796	1	54	method	method	NOUN
admet-796	1	55	for	for	ADP
admet-796	1	56	filgotinib	filgotinib	ADJ
admet-796	1	57	quantitation	quantitation	NOUN
admet-796	1	58	in	in	ADP
admet-796	1	59	rat	rat	NOUN
admet-796	1	60	dried	dry	VERB
admet-796	1	61	blood	blood	NOUN
admet-796	1	62	spots	spot	NOUN
admet-796	1	63	and	and	CCONJ
admet-796	1	64	its	its	PRON
admet-796	1	65	application	application	NOUN
admet-796	1	66	to	to	ADP
admet-796	1	67	a	a	DET
admet-796	1	68	pharmacokinetic	pharmacokinetic	ADJ
admet-796	1	69	study	study	NOUN
admet-796	1	70	in	in	ADP
admet-796	1	71	rats	rat	NOUN
admet-796	1	72	abhishek	abhishek	PROPN
admet-796	1	73	dixit	dixit	PROPN
admet-796	1	74	,	,	PUNCT
admet-796	1	75	vinay	vinay	PROPN
admet-796	1	76	kiran	kiran	PROPN
admet-796	1	77	,	,	PUNCT
admet-796	1	78	bhavesh	bhavesh	PROPN
admet-796	1	79	babulal	babulal	PROPN
admet-796	1	80	gabani	gabani	PROPN
admet-796	1	81	,	,	PUNCT
admet-796	1	82	ramesh	ramesh	PROPN
admet-796	1	83	mullangi	mullangi	PROPN
admet-796	1	84	*	*	PUNCT
admet-796	1	85	drug	drug	NOUN
admet-796	1	86	metabolism	metabolism	NOUN
admet-796	1	87	and	and	CCONJ
admet-796	1	88	pharmacokinetics	pharmacokinetic	NOUN
admet-796	1	89	,	,	PUNCT
admet-796	1	90	jubilant	jubilant	PROPN
admet-796	1	91	biosys	biosys	PROPN
admet-796	1	92	ltd	ltd	PROPN
admet-796	1	93	,	,	PUNCT
admet-796	1	94	industrial	industrial	ADJ
admet-796	1	95	suburb	suburb	NOUN
admet-796	1	96	,	,	PUNCT
admet-796	1	97	yeshwanthpur	yeshwanthpur	PROPN
admet-796	1	98	,	,	PUNCT
admet-796	1	99	bangalore-560	bangalore-560	PROPN
admet-796	1	100	022	022	NUM
admet-796	1	101	,	,	PUNCT
admet-796	1	102	india	india	PROPN
admet-796	1	103	*	*	PUNCT
admet-796	1	104	corresponding	correspond	VERB
admet-796	1	105	author	author	NOUN
admet-796	1	106	:	:	PUNCT
admet-796	1	107	e	e	NOUN
admet-796	1	108	-	-	NOUN
admet-796	1	109	mail	mail	NOUN
admet-796	1	110	:	:	PUNCT
admet-796	1	111	mullangi.ramesh@jubilantinnovation.com	mullangi.ramesh@jubilantinnovation.com	X
admet-796	1	112	;	;	PUNCT
admet-796	1	113	tel	tel	PROPN
admet-796	1	114	.	.	PUNCT
admet-796	1	115	:	:	PUNCT
admet-796	2	1	+91	+91	NOUN
admet-796	2	2	-	-	PUNCT
admet-796	2	3	80	80	NUM
admet-796	2	4	-	-	PUNCT
admet-796	2	5	66628339	66628339	NUM
admet-796	2	6	received	receive	VERB
admet-796	2	7	:	:	PUNCT
admet-796	2	8	february	february	PROPN
admet-796	2	9	24	24	NUM
admet-796	2	10	,	,	PUNCT
admet-796	2	11	2020	2020	NUM
admet-796	2	12	;	;	PUNCT
admet-796	2	13	revised	revise	VERB
admet-796	2	14	:	:	PUNCT
admet-796	2	15	april	april	PROPN
admet-796	2	16	23	23	NUM
admet-796	2	17	,	,	PUNCT
admet-796	2	18	2020	2020	NUM
admet-796	2	19	;	;	PUNCT
admet-796	2	20	published	publish	VERB
admet-796	2	21	online	online	ADV
admet-796	2	22	:	:	PUNCT
admet-796	2	23	may	may	AUX
admet-796	2	24	06	06	NUM
admet-796	2	25	,	,	PUNCT
admet-796	2	26	2020	2020	NUM
admet-796	2	27	abstract	abstract	ADJ
admet-796	2	28	filgotinib	filgotinib	NOUN
admet-796	2	29	is	be	AUX
admet-796	2	30	a	a	DET
admet-796	2	31	selective	selective	ADJ
admet-796	2	32	jak1	jak1	NOUN
admet-796	2	33	(	(	PUNCT
admet-796	2	34	janus	janus	PROPN
admet-796	2	35	kinase	kinase	PROPN
admet-796	2	36	)	)	PUNCT
admet-796	2	37	inhibitor	inhibitor	NOUN
admet-796	2	38	,	,	PUNCT
admet-796	2	39	showed	show	VERB
admet-796	2	40	efficacy	efficacy	NOUN
admet-796	2	41	in	in	ADP
admet-796	2	42	patients	patient	NOUN
admet-796	2	43	suffering	suffer	VERB
admet-796	2	44	from	from	ADP
admet-796	2	45	moderateto	moderateto	NOUN
admet-796	2	46	-	-	PUNCT
admet-796	2	47	severe	severe	ADJ
admet-796	2	48	rheumatoid	rheumatoid	NOUN
admet-796	2	49	arthritis	arthritis	NOUN
admet-796	2	50	.	.	PUNCT
admet-796	3	1	in	in	ADP
admet-796	3	2	this	this	DET
admet-796	3	3	paper	paper	NOUN
admet-796	3	4	,	,	PUNCT
admet-796	3	5	we	we	PRON
admet-796	3	6	present	present	VERB
admet-796	3	7	the	the	DET
admet-796	3	8	data	datum	NOUN
admet-796	3	9	on	on	ADP
admet-796	3	10	the	the	DET
admet-796	3	11	development	development	NOUN
admet-796	3	12	and	and	CCONJ
admet-796	3	13	validation	validation	NOUN
admet-796	3	14	of	of	ADP
admet-796	3	15	a	a	DET
admet-796	3	16	sensitive	sensitive	ADJ
admet-796	3	17	,	,	PUNCT
admet-796	3	18	selective	selective	ADJ
admet-796	3	19	and	and	CCONJ
admet-796	3	20	high	high	ADJ
admet-796	3	21	-	-	PUNCT
admet-796	3	22	throughput	throughput	NOUN
admet-796	3	23	lc	lc	PROPN
admet-796	3	24	-	-	PUNCT
admet-796	3	25	ms	ms	PROPN
admet-796	3	26	/	/	SYM
admet-796	3	27	ms	ms	NOUN
admet-796	3	28	(	(	PUNCT
admet-796	3	29	liquid	liquid	ADJ
admet-796	3	30	chromatography	chromatography	NOUN
admet-796	3	31	with	with	ADP
admet-796	3	32	tandem	tandem	PROPN
admet-796	3	33	mass	mass	PROPN
admet-796	3	34	spectrometry	spectrometry	NOUN
admet-796	3	35	)	)	PUNCT
admet-796	3	36	method	method	NOUN
admet-796	3	37	for	for	ADP
admet-796	3	38	the	the	DET
admet-796	3	39	quantitation	quantitation	NOUN
admet-796	3	40	of	of	ADP
admet-796	3	41	filgotinib	filgotinib	NOUN
admet-796	3	42	from	from	ADP
admet-796	3	43	rat	rat	NOUN
admet-796	3	44	dried	dry	VERB
admet-796	3	45	blood	blood	NOUN
admet-796	3	46	spot	spot	NOUN
admet-796	3	47	(	(	PUNCT
admet-796	3	48	dbs	dbs	NOUN
admet-796	3	49	)	)	PUNCT
admet-796	3	50	cards	card	NOUN
admet-796	3	51	.	.	PUNCT
admet-796	4	1	to	to	ADP
admet-796	4	2	the	the	DET
admet-796	4	3	dbs	dbs	NOUN
admet-796	4	4	disc	disc	NOUN
admet-796	4	5	cards	card	NOUN
admet-796	4	6	,	,	PUNCT
admet-796	4	7	0.2	0.2	NUM
admet-796	4	8	%	%	NOUN
admet-796	4	9	formic	formic	PROPN
admet-796	4	10	acid	acid	NOUN
admet-796	4	11	enriched	enrich	VERB
admet-796	4	12	with	with	ADP
admet-796	4	13	internal	internal	ADJ
admet-796	4	14	standard	standard	NOUN
admet-796	4	15	(	(	PUNCT
admet-796	4	16	is	be	AUX
admet-796	4	17	)	)	PUNCT
admet-796	4	18	was	be	AUX
admet-796	4	19	added	add	VERB
admet-796	4	20	and	and	CCONJ
admet-796	4	21	sonicated	sonicate	VERB
admet-796	4	22	.	.	PUNCT
admet-796	5	1	thereafter	thereafter	ADV
admet-796	5	2	the	the	DET
admet-796	5	3	extraction	extraction	NOUN
admet-796	5	4	of	of	ADP
admet-796	5	5	filgotinib	filgotinib	NOUN
admet-796	5	6	and	and	CCONJ
admet-796	5	7	the	the	DET
admet-796	5	8	is	be	AUX
admet-796	5	9	(	(	PUNCT
admet-796	5	10	tofacitinib	tofacitinib	PROPN
admet-796	5	11	)	)	PUNCT
admet-796	5	12	was	be	AUX
admet-796	5	13	accomplished	accomplish	VERB
admet-796	5	14	using	use	VERB
admet-796	5	15	ethyl	ethyl	PROPN
admet-796	5	16	acetate	acetate	NOUN
admet-796	5	17	as	as	ADP
admet-796	5	18	an	an	DET
admet-796	5	19	extraction	extraction	NOUN
admet-796	5	20	solvent	solvent	NOUN
admet-796	5	21	.	.	PUNCT
admet-796	6	1	the	the	DET
admet-796	6	2	resolution	resolution	NOUN
admet-796	6	3	of	of	ADP
admet-796	6	4	filgotinib	filgotinib	NOUN
admet-796	6	5	and	and	CCONJ
admet-796	6	6	the	the	DET
admet-796	6	7	is	be	AUX
admet-796	6	8	was	be	AUX
admet-796	6	9	achieved	achieve	VERB
admet-796	6	10	on	on	ADP
admet-796	6	11	a	a	DET
admet-796	6	12	gemini	gemini	NOUN
admet-796	6	13	c18	c18	NOUN
admet-796	6	14	column	column	NOUN
admet-796	6	15	with	with	ADP
admet-796	6	16	an	an	DET
admet-796	6	17	isocratic	isocratic	ADJ
admet-796	6	18	mobile	mobile	ADJ
admet-796	6	19	phase	phase	NOUN
admet-796	6	20	,	,	PUNCT
admet-796	6	21	which	which	PRON
admet-796	6	22	is	be	AUX
admet-796	6	23	a	a	DET
admet-796	6	24	mixture	mixture	NOUN
admet-796	6	25	of	of	ADP
admet-796	6	26	0.2	0.2	NUM
admet-796	6	27	%	%	NOUN
admet-796	6	28	formic	formic	ADJ
admet-796	6	29	acid	acid	NOUN
admet-796	6	30	:	:	PUNCT
admet-796	6	31	acetonitrile	acetonitrile	NOUN
admet-796	6	32	(	(	PUNCT
admet-796	6	33	20:80	20:80	NUM
admet-796	6	34	,	,	PUNCT
admet-796	6	35	v	v	NOUN
admet-796	6	36	/	/	SYM
admet-796	6	37	v	v	NOUN
admet-796	6	38	)	)	PUNCT
admet-796	6	39	at	at	ADP
admet-796	6	40	a	a	DET
admet-796	6	41	flow	flow	NOUN
admet-796	6	42	-	-	PUNCT
admet-796	6	43	rate	rate	NOUN
admet-796	6	44	of	of	ADP
admet-796	6	45	0.9	0.9	NUM
admet-796	6	46	ml	ml	NOUN
admet-796	6	47	/	/	SYM
admet-796	6	48	min	min	NOUN
admet-796	6	49	.	.	PUNCT
admet-796	7	1	the	the	DET
admet-796	7	2	total	total	ADJ
admet-796	7	3	run	run	NOUN
admet-796	7	4	time	time	NOUN
admet-796	7	5	was	be	AUX
admet-796	7	6	2.90	2.90	NUM
admet-796	7	7	min	min	NOUN
admet-796	7	8	and	and	CCONJ
admet-796	7	9	the	the	DET
admet-796	7	10	retention	retention	NOUN
admet-796	7	11	time	time	NOUN
admet-796	7	12	of	of	ADP
admet-796	7	13	filgotinib	filgotinib	NOUN
admet-796	7	14	and	and	CCONJ
admet-796	7	15	the	the	PRON
admet-796	7	16	is	be	AUX
admet-796	7	17	was	be	AUX
admet-796	7	18	~1.31	~1.31	PUNCT
admet-796	7	19	and	and	CCONJ
admet-796	7	20	0.89	0.89	NUM
admet-796	7	21	min	min	NOUN
admet-796	7	22	,	,	PUNCT
admet-796	7	23	respectively	respectively	ADV
admet-796	7	24	.	.	PUNCT
admet-796	8	1	filgotinib	filgotinib	PROPN
admet-796	8	2	and	and	CCONJ
admet-796	8	3	the	the	DET
admet-796	8	4	is	be	AUX
admet-796	8	5	were	be	AUX
admet-796	8	6	analyzed	analyze	VERB
admet-796	8	7	using	use	VERB
admet-796	8	8	positive	positive	ADJ
admet-796	8	9	ion	ion	NOUN
admet-796	8	10	scan	scan	NOUN
admet-796	8	11	mode	mode	NOUN
admet-796	8	12	and	and	CCONJ
admet-796	8	13	parent	parent	NOUN
admet-796	8	14	-	-	PUNCT
admet-796	8	15	daughter	daughter	NOUN
admet-796	8	16	mass	mass	NOUN
admet-796	8	17	to	to	PART
admet-796	8	18	charge	charge	VERB
admet-796	8	19	ion	ion	NOUN
admet-796	8	20	(	(	PUNCT
admet-796	8	21	m	m	NOUN
admet-796	8	22	/	/	SYM
admet-796	8	23	z	z	NOUN
admet-796	8	24	)	)	PUNCT
admet-796	8	25	transition	transition	NOUN
admet-796	8	26	of	of	ADP
admet-796	8	27	426.3291.3	426.3291.3	PROPN
admet-796	8	28	and	and	CCONJ
admet-796	8	29	m	m	PROPN
admet-796	8	30	/	/	SYM
admet-796	8	31	z	z	PROPN
admet-796	8	32	313.2149.2	313.2149.2	NUM
admet-796	8	33	,	,	PUNCT
admet-796	8	34	respectively	respectively	ADV
admet-796	8	35	,	,	PUNCT
admet-796	8	36	for	for	ADP
admet-796	8	37	quantitation	quantitation	NOUN
admet-796	8	38	.	.	PUNCT
admet-796	9	1	the	the	DET
admet-796	9	2	calibration	calibration	NOUN
admet-796	9	3	range	range	NOUN
admet-796	9	4	was	be	AUX
admet-796	9	5	1.37	1.37	NUM
admet-796	9	6	-	-	SYM
admet-796	9	7	1937	1937	NUM
admet-796	9	8	ng	ng	PROPN
admet-796	9	9	/	/	SYM
admet-796	9	10	ml	ml	PROPN
admet-796	9	11	.	.	PUNCT
admet-796	10	1	no	no	DET
admet-796	10	2	matrix	matrix	NOUN
admet-796	10	3	effect	effect	NOUN
admet-796	10	4	and	and	CCONJ
admet-796	10	5	carry	carry	VERB
admet-796	10	6	over	over	ADP
admet-796	10	7	were	be	AUX
admet-796	10	8	observed	observe	VERB
admet-796	10	9	.	.	PUNCT
admet-796	11	1	all	all	DET
admet-796	11	2	the	the	DET
admet-796	11	3	validation	validation	NOUN
admet-796	11	4	parameters	parameter	NOUN
admet-796	11	5	met	meet	VERB
admet-796	11	6	the	the	DET
admet-796	11	7	acceptance	acceptance	NOUN
admet-796	11	8	criteria	criterion	NOUN
admet-796	11	9	.	.	PUNCT
admet-796	12	1	the	the	DET
admet-796	12	2	validated	validate	VERB
admet-796	12	3	method	method	NOUN
admet-796	12	4	has	have	AUX
admet-796	12	5	been	be	AUX
admet-796	12	6	applied	apply	VERB
admet-796	12	7	to	to	ADP
admet-796	12	8	a	a	DET
admet-796	12	9	pharmacokinetic	pharmacokinetic	ADJ
admet-796	12	10	study	study	NOUN
admet-796	12	11	in	in	ADP
admet-796	12	12	rats	rat	NOUN
admet-796	12	13	.	.	PUNCT
admet-796	13	1	a	a	DET
admet-796	13	2	good	good	ADJ
admet-796	13	3	correlation	correlation	NOUN
admet-796	13	4	between	between	ADP
admet-796	13	5	dbs	dbs	NOUN
admet-796	13	6	and	and	CCONJ
admet-796	13	7	plasma	plasma	NOUN
admet-796	13	8	concentrations	concentration	NOUN
admet-796	13	9	for	for	ADP
admet-796	13	10	filgotinib	filgotinib	NOUN
admet-796	13	11	was	be	AUX
admet-796	13	12	observed	observe	VERB
admet-796	13	13	.	.	PUNCT
admet-796	14	1	©	©	PROPN
admet-796	14	2	2020	2020	NUM
admet-796	14	3	by	by	ADP
admet-796	14	4	the	the	DET
admet-796	14	5	authors	author	NOUN
admet-796	14	6	.	.	PUNCT
admet-796	15	1	this	this	DET
admet-796	15	2	article	article	NOUN
admet-796	15	3	is	be	AUX
admet-796	15	4	an	an	DET
admet-796	15	5	open	open	ADJ
admet-796	15	6	-	-	PUNCT
admet-796	15	7	access	access	NOUN
admet-796	15	8	article	article	NOUN
admet-796	15	9	distributed	distribute	VERB
admet-796	15	10	under	under	ADP
admet-796	15	11	the	the	DET
admet-796	15	12	terms	term	NOUN
admet-796	15	13	and	and	CCONJ
admet-796	15	14	conditions	condition	NOUN
admet-796	15	15	of	of	ADP
admet-796	15	16	the	the	DET
admet-796	15	17	creative	creative	ADJ
admet-796	15	18	commons	common	NOUN
admet-796	15	19	attribution	attribution	NOUN
admet-796	15	20	license	license	NOUN
admet-796	15	21	(	(	PUNCT
admet-796	15	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-796	15	23	)	)	PUNCT
admet-796	15	24	.	.	PUNCT
admet-796	16	1	keywords	keyword	NOUN
admet-796	16	2	filgotinib	filgotinib	NOUN
admet-796	16	3	;	;	PUNCT
admet-796	16	4	lc	lc	PROPN
admet-796	16	5	-	-	PUNCT
admet-796	16	6	ms	ms	PROPN
admet-796	16	7	/	/	SYM
admet-796	16	8	ms	ms	PROPN
admet-796	16	9	;	;	PUNCT
admet-796	16	10	method	method	NOUN
admet-796	16	11	validation	validation	NOUN
admet-796	16	12	;	;	PUNCT
admet-796	16	13	rat	rat	NOUN
admet-796	16	14	blood	blood	NOUN
admet-796	16	15	;	;	PUNCT
admet-796	16	16	dbs	dbs	PROPN
admet-796	16	17	;	;	PUNCT
admet-796	16	18	pharmacokinetics	pharmacokinetic	NOUN
admet-796	16	19	introduction	introduction	NOUN
admet-796	16	20	rheumatoid	rheumatoid	NOUN
admet-796	16	21	arthritis	arthritis	NOUN
admet-796	16	22	is	be	AUX
admet-796	16	23	a	a	DET
admet-796	16	24	chronic	chronic	ADJ
admet-796	16	25	autoimmune	autoimmune	ADJ
admet-796	16	26	inflammatory	inflammatory	ADJ
admet-796	16	27	disease	disease	NOUN
admet-796	16	28	with	with	ADP
admet-796	16	29	a	a	DET
admet-796	16	30	prevalence	prevalence	NOUN
admet-796	16	31	of	of	ADP
admet-796	16	32	1	1	NUM
admet-796	16	33	-	-	SYM
admet-796	16	34	2	2	NUM
admet-796	16	35	%	%	NOUN
admet-796	16	36	of	of	ADP
admet-796	16	37	the	the	DET
admet-796	16	38	world	world	NOUN
admet-796	16	39	population	population	NOUN
admet-796	16	40	.	.	PUNCT
admet-796	17	1	rheumatoid	rheumatoid	VERB
admet-796	17	2	arthritis	arthritis	NOUN
admet-796	17	3	primarily	primarily	ADV
admet-796	17	4	affects	affect	VERB
admet-796	17	5	peripheral	peripheral	ADJ
admet-796	17	6	joints	joint	NOUN
admet-796	17	7	and	and	CCONJ
admet-796	17	8	subsequently	subsequently	ADV
admet-796	17	9	damages	damage	VERB
admet-796	17	10	the	the	DET
admet-796	17	11	synovial	synovial	ADJ
admet-796	17	12	tissue	tissue	NOUN
admet-796	17	13	and	and	CCONJ
admet-796	17	14	cartilage	cartilage	NOUN
admet-796	17	15	damage	damage	NOUN
admet-796	18	1	[	[	X
admet-796	18	2	1	1	NUM
admet-796	18	3	]	]	PUNCT
admet-796	18	4	.	.	PUNCT
admet-796	19	1	although	although	SCONJ
admet-796	19	2	disease	disease	NOUN
admet-796	19	3	-	-	PUNCT
admet-796	19	4	modifying	modify	VERB
admet-796	19	5	anti	anti	ADJ
admet-796	19	6	-	-	ADJ
admet-796	19	7	rheumatic	rheumatic	ADJ
admet-796	19	8	drugs	drug	NOUN
admet-796	19	9	(	(	PUNCT
admet-796	19	10	dmards	dmard	NOUN
admet-796	19	11	:	:	PUNCT
admet-796	19	12	methotrexate	methotrexate	NOUN
admet-796	19	13	,	,	PUNCT
admet-796	19	14	sulfasalazine	sulfasalazine	NOUN
admet-796	19	15	,	,	PUNCT
admet-796	19	16	leflunomide	leflunomide	ADJ
admet-796	19	17	etc	etc	X
admet-796	19	18	)	)	PUNCT
admet-796	19	19	and	and	CCONJ
admet-796	19	20	biologic	biologic	NOUN
admet-796	19	21	dmards	dmard	NOUN
admet-796	19	22	(	(	PUNCT
admet-796	19	23	etanercept	etanercept	X
admet-796	19	24	,	,	PUNCT
admet-796	19	25	adalimumab	adalimumab	NOUN
admet-796	19	26	etc	etc	X
admet-796	19	27	.	.	X
admet-796	19	28	)	)	PUNCT
admet-796	19	29	are	be	AUX
admet-796	19	30	available	available	ADJ
admet-796	19	31	as	as	ADP
admet-796	19	32	first	first	ADJ
admet-796	19	33	-	-	PUNCT
admet-796	19	34	line	line	NOUN
admet-796	19	35	drugs	drug	NOUN
admet-796	19	36	due	due	ADP
admet-796	19	37	to	to	ADP
admet-796	19	38	their	their	PRON
admet-796	19	39	low	low	ADJ
admet-796	19	40	therapeutic	therapeutic	ADJ
admet-796	19	41	benefit	benefit	NOUN
admet-796	19	42	and	and	CCONJ
admet-796	19	43	severe	severe	ADJ
admet-796	19	44	side	side	NOUN
admet-796	19	45	effects	effect	NOUN
admet-796	19	46	they	they	PRON
admet-796	19	47	can	can	AUX
admet-796	19	48	not	not	PART
admet-796	19	49	be	be	AUX
admet-796	19	50	used	use	VERB
admet-796	19	51	for	for	ADP
admet-796	19	52	long	long	ADJ
admet-796	19	53	-	-	PUNCT
admet-796	19	54	treatment	treatment	NOUN
admet-796	19	55	[	[	X
admet-796	19	56	2	2	NUM
admet-796	19	57	]	]	PUNCT
admet-796	19	58	.	.	PUNCT
admet-796	20	1	to	to	PART
admet-796	20	2	overcome	overcome	VERB
admet-796	20	3	these	these	DET
admet-796	20	4	drawbacks	drawback	NOUN
admet-796	20	5	,	,	PUNCT
admet-796	20	6	janus	janus	PROPN
admet-796	20	7	kinase	kinase	PROPN
admet-796	20	8	(	(	PUNCT
admet-796	20	9	jak)/signal	jak)/signal	ADJ
admet-796	20	10	transducer	transducer	NOUN
admet-796	20	11	and	and	CCONJ
admet-796	20	12	activator	activator	NOUN
admet-796	20	13	of	of	ADP
admet-796	20	14	the	the	DET
admet-796	20	15	transcription	transcription	NOUN
admet-796	20	16	(	(	PUNCT
admet-796	20	17	stat	stat	NOUN
admet-796	20	18	)	)	PUNCT
admet-796	20	19	signal	signal	NOUN
admet-796	20	20	pathway	pathway	NOUN
admet-796	20	21	has	have	AUX
admet-796	20	22	been	be	AUX
admet-796	20	23	identified	identify	VERB
admet-796	20	24	as	as	ADP
admet-796	20	25	one	one	NUM
admet-796	20	26	of	of	ADP
admet-796	20	27	the	the	DET
admet-796	20	28	new	new	ADJ
admet-796	20	29	therapeutic	therapeutic	ADJ
admet-796	20	30	targets	target	NOUN
admet-796	20	31	to	to	PART
admet-796	20	32	treat	treat	VERB
admet-796	20	33	rheumatoid	rheumatoid	NOUN
admet-796	20	34	arthritis	arthritis	NOUN
admet-796	20	35	.	.	PUNCT
admet-796	21	1	jak	jak	PROPN
admet-796	21	2	-	-	PUNCT
admet-796	21	3	stat	stat	PROPN
admet-796	21	4	pathway	pathway	NOUN
admet-796	21	5	plays	play	VERB
admet-796	21	6	a	a	DET
admet-796	21	7	critical	critical	ADJ
admet-796	21	8	role	role	NOUN
admet-796	21	9	in	in	ADP
admet-796	21	10	the	the	DET
admet-796	21	11	downstream	downstream	ADJ
admet-796	21	12	signaling	signaling	NOUN
admet-796	21	13	of	of	ADP
admet-796	21	14	cytokines	cytokine	NOUN
admet-796	21	15	.	.	PUNCT
admet-796	22	1	the	the	DET
admet-796	22	2	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	ADJ
admet-796	22	3	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PUNCT
admet-796	23	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-796	23	2	mailto:mullangi.ramesh@jubilantinnovation.com	mailto:mullangi.ramesh@jubilantinnovation.com	PROPN
admet-796	24	1	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-796	24	2	r.	r.	PROPN
admet-796	24	3	mullangi	mullangi	VERB
admet-796	24	4	et	et	PROPN
admet-796	24	5	al	al	PROPN
admet-796	24	6	.	.	PROPN
admet-796	24	7	admet	admet	PROPN
admet-796	24	8	&	&	CCONJ
admet-796	24	9	dmpk	dmpk	PROPN
admet-796	24	10	8(2	8(2	NUM
admet-796	24	11	)	)	PUNCT
admet-796	24	12	(	(	PUNCT
admet-796	24	13	2020	2020	NUM
admet-796	24	14	)	)	PUNCT
admet-796	24	15	139	139	NUM
admet-796	24	16	-	-	SYM
admet-796	24	17	148	148	NUM
admet-796	24	18	140	140	NUM
admet-796	24	19	inhibition	inhibition	NOUN
admet-796	24	20	of	of	ADP
admet-796	24	21	jaks	jak	NOUN
admet-796	24	22	is	be	AUX
admet-796	24	23	an	an	DET
admet-796	24	24	attractive	attractive	ADJ
admet-796	24	25	therapeutic	therapeutic	ADJ
admet-796	24	26	target	target	NOUN
admet-796	24	27	to	to	PART
admet-796	24	28	treat	treat	VERB
admet-796	24	29	rheumatoid	rheumatoid	VERB
admet-796	24	30	arthritis	arthritis	NOUN
admet-796	25	1	[	[	X
admet-796	25	2	3	3	NUM
admet-796	25	3	]	]	PUNCT
admet-796	25	4	.	.	PUNCT
admet-796	26	1	tofacitinib	tofacitinib	NOUN
admet-796	26	2	and	and	CCONJ
admet-796	26	3	baricitinib	baricitinib	NOUN
admet-796	26	4	are	be	AUX
admet-796	26	5	the	the	DET
admet-796	26	6	pan	pan	PROPN
admet-796	26	7	-	-	PUNCT
admet-796	26	8	jak	jak	ADJ
admet-796	26	9	inhibitors	inhibitor	NOUN
admet-796	26	10	(	(	PUNCT
admet-796	26	11	jak1	jak1	NOUN
admet-796	26	12	/	/	SYM
admet-796	26	13	jak3	jak3	PROPN
admet-796	26	14	)	)	PUNCT
admet-796	26	15	approved	approve	VERB
admet-796	26	16	for	for	ADP
admet-796	26	17	the	the	DET
admet-796	26	18	treatment	treatment	NOUN
admet-796	26	19	of	of	ADP
admet-796	26	20	moderate	moderate	ADJ
admet-796	26	21	to	to	ADP
admet-796	26	22	severe	severe	ADJ
admet-796	26	23	rheumatoid	rheumatoid	NOUN
admet-796	26	24	arthritis	arthritis	NOUN
admet-796	26	25	but	but	CCONJ
admet-796	26	26	they	they	PRON
admet-796	26	27	showed	show	VERB
admet-796	26	28	dose	dose	NOUN
admet-796	26	29	-	-	PUNCT
admet-796	26	30	related	relate	VERB
admet-796	26	31	toxicities	toxicity	NOUN
admet-796	26	32	[	[	X
admet-796	26	33	4	4	NUM
admet-796	26	34	]	]	PUNCT
admet-796	26	35	.	.	PUNCT
admet-796	27	1	recent	recent	ADJ
admet-796	27	2	findings	finding	NOUN
admet-796	27	3	suggest	suggest	VERB
admet-796	27	4	that	that	SCONJ
admet-796	27	5	selective	selective	ADJ
admet-796	27	6	inhibition	inhibition	NOUN
admet-796	27	7	of	of	ADP
admet-796	27	8	jak1	jak1	NOUN
admet-796	27	9	might	might	AUX
admet-796	27	10	reduce	reduce	VERB
admet-796	27	11	the	the	DET
admet-796	27	12	toxicity	toxicity	NOUN
admet-796	27	13	without	without	ADP
admet-796	27	14	a	a	DET
admet-796	27	15	significant	significant	ADJ
admet-796	27	16	detriment	detriment	NOUN
admet-796	27	17	to	to	ADP
admet-796	27	18	efficacy	efficacy	NOUN
admet-796	27	19	[	[	X
admet-796	27	20	2,3	2,3	NUM
admet-796	27	21	]	]	PUNCT
admet-796	27	22	.	.	PUNCT
admet-796	28	1	filgotinib	filgotinib	PROPN
admet-796	28	2	(	(	PUNCT
admet-796	28	3	figure	figure	NOUN
admet-796	28	4	1	1	NUM
admet-796	28	5	;	;	PUNCT
admet-796	28	6	glpg0634	glpg0634	PROPN
admet-796	28	7	)	)	PUNCT
admet-796	28	8	,	,	PUNCT
admet-796	28	9	is	be	AUX
admet-796	28	10	a	a	DET
admet-796	28	11	selective	selective	ADJ
admet-796	28	12	jak1	jak1	NOUN
admet-796	28	13	inhibitor	inhibitor	NOUN
admet-796	28	14	(	(	PUNCT
admet-796	28	15	ic50	ic50	PROPN
admet-796	28	16	:	:	PUNCT
admet-796	28	17	629	629	NUM
admet-796	28	18	nm	nm	NOUN
admet-796	28	19	)	)	PUNCT
admet-796	28	20	with	with	ADP
admet-796	28	21	30	30	NUM
admet-796	28	22	-	-	ADJ
admet-796	28	23	fold	fold	ADJ
admet-796	28	24	selectivity	selectivity	NOUN
admet-796	28	25	over	over	ADP
admet-796	28	26	jak2	jak2	NOUN
admet-796	29	1	[	[	X
admet-796	29	2	5	5	NUM
admet-796	29	3	]	]	PUNCT
admet-796	29	4	.	.	PUNCT
admet-796	30	1	it	it	PRON
admet-796	30	2	has	have	AUX
admet-796	30	3	shown	show	VERB
admet-796	30	4	dose	dose	NOUN
admet-796	30	5	-	-	PUNCT
admet-796	30	6	dependent	dependent	ADJ
admet-796	30	7	reduction	reduction	NOUN
admet-796	30	8	of	of	ADP
admet-796	30	9	disease	disease	NOUN
admet-796	30	10	progression	progression	NOUN
admet-796	30	11	in	in	ADP
admet-796	30	12	a	a	DET
admet-796	30	13	collagen	collagen	NOUN
admet-796	30	14	-	-	PUNCT
admet-796	30	15	induced	induce	VERB
admet-796	30	16	arthritis	arthritis	NOUN
admet-796	30	17	model	model	NOUN
admet-796	30	18	post	post	PROPN
admet-796	30	19	oral	oral	ADJ
admet-796	30	20	administration	administration	NOUN
admet-796	30	21	in	in	ADP
admet-796	30	22	rodents	rodent	NOUN
admet-796	30	23	[	[	X
admet-796	30	24	5	5	NUM
admet-796	30	25	]	]	PUNCT
admet-796	30	26	.	.	PUNCT
admet-796	31	1	in	in	ADP
admet-796	31	2	phase-3	phase-3	NUM
admet-796	31	3	clinical	clinical	ADJ
admet-796	31	4	trials	trial	NOUN
admet-796	31	5	,	,	PUNCT
admet-796	31	6	filgotinib	filgotinib	NOUN
admet-796	31	7	was	be	AUX
admet-796	31	8	well	well	ADV
admet-796	31	9	tolerated	tolerate	VERB
admet-796	31	10	,	,	PUNCT
admet-796	31	11	showed	show	VERB
admet-796	31	12	efficacy	efficacy	NOUN
admet-796	31	13	and	and	CCONJ
admet-796	31	14	was	be	AUX
admet-796	31	15	found	find	VERB
admet-796	31	16	to	to	PART
admet-796	31	17	be	be	AUX
admet-796	31	18	safe	safe	ADJ
admet-796	31	19	in	in	ADP
admet-796	31	20	rheumatoid	rheumatoid	ADJ
admet-796	31	21	arthritis	arthritis	NOUN
admet-796	31	22	patients	patient	NOUN
admet-796	31	23	,	,	PUNCT
admet-796	31	24	when	when	SCONJ
admet-796	31	25	it	it	PRON
admet-796	31	26	was	be	AUX
admet-796	31	27	administered	administer	VERB
admet-796	31	28	as	as	ADP
admet-796	31	29	monotherapy	monotherapy	NOUN
admet-796	31	30	at	at	ADP
admet-796	31	31	100	100	NUM
admet-796	31	32	or	or	CCONJ
admet-796	31	33	200	200	NUM
admet-796	31	34	mg	mg	NOUN
admet-796	31	35	,	,	PUNCT
admet-796	31	36	once	once	ADV
admet-796	31	37	daily	daily	ADV
admet-796	31	38	or	or	CCONJ
admet-796	31	39	with	with	ADP
admet-796	31	40	methotrexate	methotrexate	NOUN
admet-796	32	1	[	[	X
admet-796	32	2	6	6	NUM
admet-796	32	3	]	]	PUNCT
admet-796	32	4	.	.	PUNCT
admet-796	33	1	filgotinib	filgotinib	PROPN
admet-796	33	2	is	be	AUX
admet-796	33	3	currently	currently	ADV
admet-796	33	4	being	be	AUX
admet-796	33	5	filed	file	VERB
admet-796	33	6	in	in	ADP
admet-796	33	7	the	the	DET
admet-796	33	8	us	us	PROPN
admet-796	33	9	and	and	CCONJ
admet-796	33	10	japan	japan	PROPN
admet-796	33	11	to	to	PART
admet-796	33	12	treat	treat	VERB
admet-796	33	13	the	the	DET
admet-796	33	14	patients	patient	NOUN
admet-796	33	15	suffering	suffer	VERB
admet-796	33	16	from	from	ADP
admet-796	33	17	moderate	moderate	ADJ
admet-796	33	18	-	-	PUNCT
admet-796	33	19	to	to	ADP
admet-796	33	20	-	-	PUNCT
admet-796	33	21	severe	severe	ADJ
admet-796	33	22	rheumatoid	rheumatoid	NOUN
admet-796	33	23	arthritis	arthritis	NOUN
admet-796	33	24	[	[	X
admet-796	33	25	7,8	7,8	NUM
admet-796	33	26	]	]	PUNCT
admet-796	33	27	.	.	PUNCT
admet-796	34	1	filgotinib	filgotinib	PROPN
admet-796	34	2	tofacitinib	tofacitinib	PROPN
admet-796	34	3	(	(	PUNCT
admet-796	34	4	is	be	AUX
admet-796	34	5	;	;	PUNCT
admet-796	34	6	internal	internal	ADJ
admet-796	34	7	standard	standard	NOUN
admet-796	34	8	)	)	PUNCT
admet-796	34	9	figure	figure	NOUN
admet-796	34	10	1	1	NUM
admet-796	34	11	.	.	PUNCT
admet-796	34	12	structural	structural	ADJ
admet-796	34	13	representation	representation	NOUN
admet-796	34	14	of	of	ADP
admet-796	34	15	filgotinib	filgotinib	NOUN
admet-796	34	16	and	and	CCONJ
admet-796	34	17	tofacitinib	tofacitinib	NOUN
admet-796	34	18	(	(	PUNCT
admet-796	34	19	is	be	AUX
admet-796	34	20	)	)	PUNCT
admet-796	34	21	.	.	PUNCT
admet-796	35	1	to	to	ADP
admet-796	35	2	date	date	NOUN
admet-796	35	3	,	,	PUNCT
admet-796	35	4	two	two	NUM
admet-796	35	5	lc	lc	PROPN
admet-796	35	6	-	-	PUNCT
admet-796	35	7	ms	ms	PROPN
admet-796	35	8	/	/	SYM
admet-796	35	9	ms	ms	NOUN
admet-796	35	10	(	(	PUNCT
admet-796	35	11	liquid	liquid	ADJ
admet-796	35	12	chromatography	chromatography	NOUN
admet-796	35	13	with	with	ADP
admet-796	35	14	tandem	tandem	PROPN
admet-796	35	15	mass	mass	PROPN
admet-796	35	16	spectrometry	spectrometry	NOUN
admet-796	35	17	)	)	PUNCT
admet-796	35	18	methods	method	NOUN
admet-796	35	19	were	be	AUX
admet-796	35	20	reported	report	VERB
admet-796	35	21	for	for	ADP
admet-796	35	22	the	the	DET
admet-796	35	23	quantification	quantification	NOUN
admet-796	35	24	of	of	ADP
admet-796	35	25	filgotinib	filgotinib	NOUN
admet-796	35	26	.	.	PUNCT
admet-796	36	1	the	the	DET
admet-796	36	2	first	first	ADJ
admet-796	36	3	method	method	NOUN
admet-796	36	4	,	,	PUNCT
admet-796	36	5	reported	report	VERB
admet-796	36	6	by	by	ADP
admet-796	36	7	namuor	namuor	PROPN
admet-796	36	8	et	et	PROPN
admet-796	36	9	al	al	PROPN
admet-796	36	10	.	.	PROPN
admet-796	36	11	(	(	PUNCT
admet-796	36	12	2015	2015	NUM
admet-796	36	13	)	)	PUNCT
admet-796	36	14	employed	employ	VERB
admet-796	36	15	solid	solid	ADJ
admet-796	36	16	-	-	PUNCT
admet-796	36	17	phase	phase	NOUN
admet-796	36	18	extraction	extraction	NOUN
admet-796	36	19	method	method	NOUN
admet-796	36	20	for	for	ADP
admet-796	36	21	the	the	DET
admet-796	36	22	quantitation	quantitation	NOUN
admet-796	36	23	of	of	ADP
admet-796	36	24	filgotinib	filgotinib	NOUN
admet-796	36	25	and	and	CCONJ
admet-796	36	26	its	its	PRON
admet-796	36	27	active	active	ADJ
admet-796	36	28	metabolite	metabolite	NOUN
admet-796	36	29	from	from	ADP
admet-796	36	30	phase	phase	NOUN
admet-796	36	31	-	-	PUNCT
admet-796	36	32	i	i	PRON
admet-796	36	33	study	study	VERB
admet-796	36	34	plasma	plasma	NOUN
admet-796	36	35	samples	sample	NOUN
admet-796	36	36	[	[	X
admet-796	36	37	100	100	NUM
admet-796	36	38	µl	µl	ADP
admet-796	36	39	plasma	plasma	NOUN
admet-796	36	40	sample	sample	NOUN
admet-796	36	41	was	be	AUX
admet-796	36	42	spiked	spike	VERB
admet-796	36	43	with	with	ADP
admet-796	36	44	20	20	NUM
admet-796	36	45	µl	µl	NOUN
admet-796	36	46	of	of	ADP
admet-796	36	47	deuterated	deuterate	VERB
admet-796	36	48	filgotinib	filgotinib	NOUN
admet-796	36	49	(	(	PUNCT
admet-796	36	50	125	125	NUM
admet-796	36	51	ng	ng	NOUN
admet-796	36	52	/	/	SYM
admet-796	36	53	ml	ml	NOUN
admet-796	36	54	)	)	PUNCT
admet-796	36	55	as	as	ADP
admet-796	36	56	an	an	DET
admet-796	36	57	internal	internal	ADJ
admet-796	36	58	standard	standard	NOUN
admet-796	36	59	]	]	PUNCT
admet-796	36	60	.	.	PUNCT
admet-796	37	1	the	the	DET
admet-796	37	2	reported	report	VERB
admet-796	37	3	lower	low	ADJ
admet-796	37	4	limit	limit	NOUN
admet-796	37	5	of	of	ADP
admet-796	37	6	quantification	quantification	NOUN
admet-796	37	7	(	(	PUNCT
admet-796	37	8	lloq	lloq	PROPN
admet-796	37	9	)	)	PUNCT
admet-796	37	10	was	be	AUX
admet-796	37	11	3.00	3.00	NUM
admet-796	37	12	ng	ng	NOUN
admet-796	37	13	/	/	SYM
admet-796	37	14	ml	ml	PROPN
admet-796	37	15	.	.	PUNCT
admet-796	38	1	however	however	ADV
admet-796	38	2	,	,	PUNCT
admet-796	38	3	full	full	ADJ
admet-796	38	4	details	detail	NOUN
admet-796	38	5	on	on	ADP
admet-796	38	6	chromatography	chromatography	NOUN
admet-796	38	7	,	,	PUNCT
admet-796	38	8	mass	mass	ADJ
admet-796	38	9	spectrometer	spectrometer	NOUN
admet-796	38	10	conditions	condition	NOUN
admet-796	38	11	and	and	CCONJ
admet-796	38	12	validation	validation	NOUN
admet-796	38	13	parameters	parameter	NOUN
admet-796	38	14	were	be	AUX
admet-796	38	15	not	not	PART
admet-796	38	16	reported	report	VERB
admet-796	38	17	[	[	X
admet-796	38	18	9	9	NUM
admet-796	38	19	]	]	PUNCT
admet-796	38	20	.	.	PUNCT
admet-796	39	1	very	very	ADV
admet-796	39	2	recently	recently	ADV
admet-796	39	3	,	,	PUNCT
admet-796	39	4	dixit	dixit	PROPN
admet-796	39	5	et	et	PROPN
admet-796	39	6	al	al	PROPN
admet-796	39	7	.	.	PROPN
admet-796	39	8	(	(	PUNCT
admet-796	39	9	2020	2020	NUM
admet-796	39	10	)	)	PUNCT
admet-796	39	11	reported	report	VERB
admet-796	39	12	a	a	DET
admet-796	39	13	validated	validate	VERB
admet-796	39	14	lc	lc	NOUN
admet-796	39	15	-	-	PUNCT
admet-796	39	16	ms	ms	NOUN
admet-796	39	17	/	/	SYM
admet-796	39	18	ms	ms	PROPN
admet-796	39	19	method	method	NOUN
admet-796	39	20	for	for	ADP
admet-796	39	21	the	the	DET
admet-796	39	22	quantification	quantification	NOUN
admet-796	39	23	of	of	ADP
admet-796	39	24	filgotinib	filgotinib	NOUN
admet-796	39	25	.	.	PUNCT
admet-796	40	1	the	the	DET
admet-796	40	2	authors	author	NOUN
admet-796	40	3	have	have	AUX
admet-796	40	4	attained	attain	VERB
admet-796	40	5	an	an	DET
admet-796	40	6	lloq	lloq	NOUN
admet-796	40	7	of	of	ADP
admet-796	40	8	0.78	0.78	NUM
admet-796	40	9	ng	ng	NOUN
admet-796	40	10	/	/	SYM
admet-796	40	11	ml	ml	NOUN
admet-796	40	12	with	with	ADP
admet-796	40	13	50	50	NUM
admet-796	40	14	µl	µl	ADP
admet-796	40	15	rat	rat	NOUN
admet-796	40	16	plasma	plasma	NOUN
admet-796	40	17	.	.	PUNCT
admet-796	41	1	plasma	plasma	NOUN
admet-796	41	2	samples	sample	NOUN
admet-796	41	3	were	be	AUX
admet-796	41	4	processed	process	VERB
admet-796	41	5	using	use	VERB
admet-796	41	6	ethyl	ethyl	PROPN
admet-796	41	7	acetate	acetate	NOUN
admet-796	41	8	as	as	ADP
admet-796	41	9	an	an	DET
admet-796	41	10	extraction	extraction	NOUN
admet-796	41	11	solvent	solvent	NOUN
admet-796	42	1	[	[	X
admet-796	42	2	10	10	NUM
admet-796	42	3	]	]	PUNCT
admet-796	42	4	.	.	PUNCT
admet-796	43	1	dried	dry	VERB
admet-796	43	2	blood	blood	NOUN
admet-796	43	3	spot	spot	NOUN
admet-796	43	4	(	(	PUNCT
admet-796	43	5	dbs	dbs	PROPN
admet-796	43	6	)	)	PUNCT
admet-796	43	7	methodology	methodology	NOUN
admet-796	43	8	has	have	AUX
admet-796	43	9	seen	see	VERB
admet-796	43	10	significant	significant	ADJ
admet-796	43	11	progress	progress	NOUN
admet-796	43	12	during	during	ADP
admet-796	43	13	recent	recent	ADJ
admet-796	43	14	times	time	NOUN
admet-796	43	15	in	in	ADP
admet-796	43	16	the	the	DET
admet-796	43	17	quantitative	quantitative	ADJ
admet-796	43	18	analysis	analysis	NOUN
admet-796	43	19	of	of	ADP
admet-796	43	20	various	various	ADJ
admet-796	43	21	drugs	drug	NOUN
admet-796	43	22	[	[	X
admet-796	43	23	11	11	NUM
admet-796	43	24	-	-	SYM
admet-796	43	25	16	16	NUM
admet-796	43	26	]	]	PUNCT
admet-796	43	27	.	.	PUNCT
admet-796	44	1	dbs	dbs	PROPN
admet-796	44	2	offers	offer	VERB
admet-796	44	3	several	several	ADJ
admet-796	44	4	advantages	advantage	NOUN
admet-796	44	5	over	over	ADP
admet-796	44	6	traditional	traditional	ADJ
admet-796	44	7	sampling	sampling	NOUN
admet-796	44	8	(	(	PUNCT
admet-796	44	9	plasma	plasma	NOUN
admet-796	44	10	/	/	SYM
admet-796	44	11	blood	blood	NOUN
admet-796	44	12	/	/	SYM
admet-796	44	13	serum	serum	NOUN
admet-796	44	14	)	)	PUNCT
admet-796	44	15	techniques	technique	NOUN
admet-796	44	16	such	such	ADJ
admet-796	44	17	as	as	ADP
admet-796	44	18	reduction	reduction	NOUN
admet-796	44	19	of	of	ADP
admet-796	44	20	commercial	commercial	ADJ
admet-796	44	21	costs	cost	NOUN
admet-796	44	22	for	for	ADP
admet-796	44	23	laboratory	laboratory	NOUN
admet-796	44	24	equipment	equipment	NOUN
admet-796	44	25	,	,	PUNCT
admet-796	44	26	convenience	convenience	NOUN
admet-796	44	27	in	in	ADP
admet-796	44	28	collection	collection	NOUN
admet-796	44	29	,	,	PUNCT
admet-796	44	30	reduction	reduction	NOUN
admet-796	44	31	in	in	ADP
admet-796	44	32	collection	collection	NOUN
admet-796	44	33	of	of	ADP
admet-796	44	34	blood	blood	NOUN
admet-796	44	35	volume	volume	NOUN
admet-796	44	36	,	,	PUNCT
admet-796	44	37	no	no	DET
admet-796	44	38	requirements	requirement	NOUN
admet-796	44	39	for	for	ADP
admet-796	44	40	trained	train	VERB
admet-796	44	41	phlebotomist	phlebotomist	NOUN
admet-796	44	42	,	,	PUNCT
admet-796	44	43	ease	ease	NOUN
admet-796	44	44	of	of	ADP
admet-796	44	45	sample	sample	NOUN
admet-796	44	46	handling	handling	NOUN
admet-796	44	47	/	/	SYM
admet-796	44	48	storage	storage	NOUN
admet-796	44	49	/	/	SYM
admet-796	44	50	shipping	shipping	NOUN
admet-796	44	51	,	,	PUNCT
admet-796	44	52	safety	safety	NOUN
admet-796	44	53	in	in	ADP
admet-796	44	54	handling	handling	NOUN
admet-796	44	55	,	,	PUNCT
admet-796	44	56	less	less	ADJ
admet-796	44	57	time	time	NOUN
admet-796	44	58	in	in	ADP
admet-796	44	59	processing	processing	NOUN
admet-796	44	60	and	and	CCONJ
admet-796	44	61	increase	increase	NOUN
admet-796	44	62	in	in	ADP
admet-796	44	63	throughput	throughput	NOUN
admet-796	44	64	etc	etc	X
admet-796	44	65	.	.	PUNCT
admet-796	45	1	it	it	PRON
admet-796	45	2	is	be	AUX
admet-796	45	3	anticipated	anticipate	VERB
admet-796	45	4	that	that	SCONJ
admet-796	45	5	much	much	ADJ
admet-796	45	6	clinical	clinical	ADJ
admet-796	45	7	development	development	NOUN
admet-796	45	8	and	and	CCONJ
admet-796	45	9	therapeutic	therapeutic	ADJ
admet-796	45	10	drug	drug	NOUN
admet-796	45	11	monitoring	monitoring	NOUN
admet-796	45	12	programs	program	NOUN
admet-796	45	13	in	in	ADP
admet-796	45	14	the	the	DET
admet-796	45	15	future	future	NOUN
admet-796	45	16	may	may	AUX
admet-796	45	17	switch	switch	VERB
admet-796	45	18	to	to	ADP
admet-796	45	19	dbs	dbs	PROPN
admet-796	45	20	technique	technique	NOUN
admet-796	45	21	to	to	PART
admet-796	45	22	characterize	characterize	VERB
admet-796	45	23	the	the	DET
admet-796	45	24	pharmacokinetic	pharmacokinetic	ADJ
admet-796	45	25	data	datum	NOUN
admet-796	45	26	.	.	PUNCT
admet-796	46	1	to	to	ADP
admet-796	46	2	the	the	DET
admet-796	46	3	best	good	ADJ
admet-796	46	4	of	of	ADP
admet-796	46	5	our	our	PRON
admet-796	46	6	knowledge	knowledge	NOUN
admet-796	46	7	,	,	PUNCT
admet-796	46	8	there	there	PRON
admet-796	46	9	is	be	VERB
admet-796	46	10	no	no	DET
admet-796	46	11	dbs	dbs	NOUN
admet-796	46	12	method	method	NOUN
admet-796	46	13	reported	report	VERB
admet-796	46	14	for	for	ADP
admet-796	46	15	the	the	DET
admet-796	46	16	quantitation	quantitation	NOUN
admet-796	46	17	of	of	ADP
admet-796	46	18	filgotinib	filgotinib	NOUN
admet-796	46	19	.	.	PUNCT
admet-796	47	1	in	in	ADP
admet-796	47	2	this	this	DET
admet-796	47	3	paper	paper	NOUN
admet-796	47	4	,	,	PUNCT
admet-796	47	5	we	we	PRON
admet-796	47	6	report	report	VERB
admet-796	47	7	the	the	DET
admet-796	47	8	development	development	NOUN
admet-796	47	9	and	and	CCONJ
admet-796	47	10	validation	validation	NOUN
admet-796	47	11	of	of	ADP
admet-796	47	12	an	an	DET
admet-796	47	13	lc	lc	NOUN
admet-796	47	14	-	-	PUNCT
admet-796	47	15	ms	ms	PROPN
admet-796	47	16	/	/	SYM
admet-796	47	17	ms	ms	PROPN
admet-796	47	18	method	method	NOUN
admet-796	47	19	for	for	ADP
admet-796	47	20	the	the	DET
admet-796	47	21	quantitation	quantitation	NOUN
admet-796	47	22	of	of	ADP
admet-796	47	23	filgotinib	filgotinib	NOUN
admet-796	47	24	on	on	ADP
admet-796	47	25	rat	rat	NOUN
admet-796	47	26	dbs	dbs	PROPN
admet-796	47	27	.	.	PUNCT
admet-796	48	1	the	the	DET
admet-796	48	2	applicability	applicability	NOUN
admet-796	48	3	of	of	ADP
admet-796	48	4	the	the	DET
admet-796	48	5	validated	validate	VERB
admet-796	48	6	method	method	NOUN
admet-796	48	7	was	be	AUX
admet-796	48	8	shown	show	VERB
admet-796	48	9	in	in	ADP
admet-796	48	10	a	a	DET
admet-796	48	11	rat	rat	NOUN
admet-796	48	12	pharmacokinetic	pharmacokinetic	ADJ
admet-796	48	13	study	study	NOUN
admet-796	48	14	.	.	PUNCT
admet-796	49	1	excellent	excellent	ADJ
admet-796	49	2	correlation	correlation	NOUN
admet-796	49	3	was	be	AUX
admet-796	49	4	observed	observe	VERB
admet-796	49	5	between	between	ADP
admet-796	49	6	dbs	dbs	PROPN
admet-796	49	7	versus	versus	ADP
admet-796	49	8	plasma	plasma	NOUN
admet-796	49	9	filgotinib	filgotinib	NOUN
admet-796	49	10	concentrations	concentration	NOUN
admet-796	49	11	,	,	PUNCT
admet-796	49	12	indicating	indicate	VERB
admet-796	49	13	that	that	SCONJ
admet-796	49	14	the	the	DET
admet-796	49	15	dbs	dbs	PROPN
admet-796	49	16	method	method	NOUN
admet-796	49	17	can	can	AUX
admet-796	49	18	be	be	AUX
admet-796	49	19	used	use	VERB
admet-796	49	20	as	as	ADP
admet-796	49	21	an	an	DET
admet-796	49	22	alternative	alternative	NOUN
admet-796	49	23	for	for	ADP
admet-796	49	24	plasma	plasma	NOUN
admet-796	49	25	sampling	sample	VERB
admet-796	49	26	for	for	ADP
admet-796	49	27	pharmacokinetic	pharmacokinetic	ADJ
admet-796	49	28	analysis	analysis	NOUN
admet-796	49	29	.	.	PUNCT
admet-796	50	1	admet	admet	PROPN
admet-796	50	2	&	&	CCONJ
admet-796	50	3	dmpk	dmpk	PROPN
admet-796	50	4	8(2	8(2	NUM
admet-796	50	5	)	)	PUNCT
admet-796	50	6	(	(	PUNCT
admet-796	50	7	2020	2020	NUM
admet-796	50	8	)	)	PUNCT
admet-796	50	9	139	139	NUM
admet-796	50	10	-	-	SYM
admet-796	50	11	148	148	NUM
admet-796	50	12	dbs	dbs	NOUN
admet-796	50	13	method	method	NOUN
admet-796	50	14	for	for	ADP
admet-796	50	15	filgotinib	filgotinib	ADJ
admet-796	50	16	quantitation	quantitation	NOUN
admet-796	50	17	doi	doi	NOUN
admet-796	50	18	:	:	PUNCT
admet-796	50	19	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	ADJ
admet-796	50	20	141	141	NUM
admet-796	50	21	materials	material	NOUN
admet-796	50	22	and	and	CCONJ
admet-796	50	23	methods	method	NOUN
admet-796	50	24	materials	material	NOUN
admet-796	50	25	filgotinib	filgotinib	NOUN
admet-796	50	26	(	(	PUNCT
admet-796	50	27	purity	purity	NOUN
admet-796	50	28	:	:	PUNCT
admet-796	50	29	>	>	X
admet-796	50	30	95	95	NUM
admet-796	50	31	%	%	NOUN
admet-796	50	32	)	)	PUNCT
admet-796	50	33	was	be	AUX
admet-796	50	34	purchased	purchase	VERB
admet-796	50	35	from	from	ADP
admet-796	50	36	angene	angene	PROPN
admet-796	50	37	international	international	PROPN
admet-796	50	38	limited	limited	PROPN
admet-796	50	39	,	,	PUNCT
admet-796	50	40	tsuen	tsuen	PROPN
admet-796	50	41	wan	wan	PROPN
admet-796	50	42	,	,	PUNCT
admet-796	50	43	hong	hong	PROPN
admet-796	50	44	kong	kong	PROPN
admet-796	50	45	.	.	PUNCT
admet-796	51	1	tofacitinib	tofacitinib	PROPN
admet-796	51	2	(	(	PUNCT
admet-796	51	3	is	be	AUX
admet-796	51	4	;	;	PUNCT
admet-796	51	5	purity	purity	NOUN
admet-796	51	6	:	:	PUNCT
admet-796	51	7	98	98	NUM
admet-796	51	8	%	%	NOUN
admet-796	51	9	)	)	PUNCT
admet-796	51	10	was	be	AUX
admet-796	51	11	purchased	purchase	VERB
admet-796	51	12	from	from	ADP
admet-796	51	13	sigma	sigma	PROPN
admet-796	51	14	-	-	PUNCT
admet-796	51	15	aldrich	aldrich	PROPN
admet-796	51	16	(	(	PUNCT
admet-796	51	17	st	st	PROPN
admet-796	51	18	.	.	PROPN
admet-796	51	19	louis	louis	PROPN
admet-796	51	20	,	,	PUNCT
admet-796	51	21	usa	usa	PROPN
admet-796	51	22	)	)	PUNCT
admet-796	51	23	.	.	PUNCT
admet-796	52	1	hplc	hplc	NOUN
admet-796	52	2	grade	grade	NOUN
admet-796	52	3	acetonitrile	acetonitrile	NOUN
admet-796	52	4	and	and	CCONJ
admet-796	52	5	methanol	methanol	NOUN
admet-796	52	6	were	be	AUX
admet-796	52	7	purchased	purchase	VERB
admet-796	52	8	from	from	ADP
admet-796	52	9	j.t	j.t	PROPN
admet-796	52	10	.	.	PROPN
admet-796	52	11	baker	baker	PROPN
admet-796	52	12	,	,	PUNCT
admet-796	52	13	pa	pa	PROPN
admet-796	52	14	,	,	PUNCT
admet-796	52	15	usa	usa	PROPN
admet-796	52	16	.	.	PROPN
admet-796	52	17	analytical	analytical	ADJ
admet-796	52	18	grade	grade	NOUN
admet-796	52	19	formic	formic	PROPN
admet-796	52	20	acid	acid	PROPN
admet-796	52	21	was	be	AUX
admet-796	52	22	purchased	purchase	VERB
admet-796	52	23	from	from	ADP
admet-796	52	24	s.d	s.d	PROPN
admet-796	52	25	fine	fine	ADJ
admet-796	52	26	chemicals	chemical	NOUN
admet-796	52	27	,	,	PUNCT
admet-796	52	28	mumbai	mumbai	PROPN
admet-796	52	29	,	,	PUNCT
admet-796	52	30	india	india	PROPN
admet-796	52	31	.	.	PUNCT
admet-796	53	1	all	all	DET
admet-796	53	2	other	other	ADJ
admet-796	53	3	chemicals	chemical	NOUN
admet-796	53	4	and	and	CCONJ
admet-796	53	5	reagents	reagent	NOUN
admet-796	53	6	were	be	AUX
admet-796	53	7	of	of	ADP
admet-796	53	8	analytical	analytical	ADJ
admet-796	53	9	grade	grade	NOUN
admet-796	53	10	and	and	CCONJ
admet-796	53	11	used	use	VERB
admet-796	53	12	without	without	ADP
admet-796	53	13	further	further	ADJ
admet-796	53	14	purification	purification	NOUN
admet-796	53	15	.	.	PUNCT
admet-796	54	1	the	the	DET
admet-796	54	2	control	control	PROPN
admet-796	54	3	sprague	sprague	PROPN
admet-796	54	4	dawley	dawley	PROPN
admet-796	54	5	rat	rat	NOUN
admet-796	54	6	blood	blood	NOUN
admet-796	54	7	was	be	AUX
admet-796	54	8	procured	procure	VERB
admet-796	54	9	from	from	ADP
admet-796	54	10	animal	animal	NOUN
admet-796	54	11	house	house	NOUN
admet-796	54	12	,	,	PUNCT
admet-796	54	13	jubilant	jubilant	ADJ
admet-796	54	14	biosys	biosy	NOUN
admet-796	54	15	,	,	PUNCT
admet-796	54	16	bangalore	bangalore	NOUN
admet-796	54	17	.	.	PUNCT
admet-796	55	1	liquid	liquid	ADJ
admet-796	55	2	chromatography	chromatography	NOUN
admet-796	55	3	and	and	CCONJ
admet-796	55	4	mass	mass	ADJ
admet-796	55	5	spectrometry	spectrometry	NOUN
admet-796	55	6	conditions	condition	NOUN
admet-796	55	7	we	we	PRON
admet-796	55	8	used	use	VERB
admet-796	55	9	the	the	DET
admet-796	55	10	similar	similar	ADJ
admet-796	55	11	chromatographic	chromatographic	ADJ
admet-796	55	12	conditions	condition	NOUN
admet-796	55	13	that	that	PRON
admet-796	55	14	we	we	PRON
admet-796	55	15	previously	previously	ADV
admet-796	55	16	reported	report	VERB
admet-796	55	17	[	[	X
admet-796	55	18	10	10	NUM
admet-796	55	19	]	]	PUNCT
admet-796	55	20	.	.	PUNCT
admet-796	56	1	in	in	ADP
admet-796	56	2	brief	brief	NOUN
admet-796	56	3	,	,	PUNCT
admet-796	56	4	a	a	DET
admet-796	56	5	gemini	gemini	NOUN
admet-796	56	6	c18	c18	NOUN
admet-796	56	7	(	(	PUNCT
admet-796	56	8	100	100	NUM
admet-796	56	9	×	×	NOUN
admet-796	56	10	4.6	4.6	NUM
admet-796	56	11	mm	mm	NOUN
admet-796	56	12	,	,	PUNCT
admet-796	56	13	3	3	NUM
admet-796	56	14	µm	µm	NOUN
admet-796	56	15	)	)	PUNCT
admet-796	56	16	column	column	NOUN
admet-796	56	17	maintained	maintain	VERB
admet-796	56	18	at	at	ADP
admet-796	56	19	ambient	ambient	ADJ
admet-796	56	20	room	room	NOUN
admet-796	56	21	temperature	temperature	NOUN
admet-796	56	22	along	along	ADP
admet-796	56	23	with	with	ADP
admet-796	56	24	an	an	DET
admet-796	56	25	isocratic	isocratic	ADJ
admet-796	56	26	mobile	mobile	ADJ
admet-796	56	27	phase	phase	NOUN
admet-796	56	28	(	(	PUNCT
admet-796	56	29	0.2	0.2	NUM
admet-796	56	30	%	%	NOUN
admet-796	56	31	formic	formic	ADJ
admet-796	56	32	acid	acid	NOUN
admet-796	56	33	in	in	ADP
admet-796	56	34	milli	milli	ADJ
admet-796	56	35	-	-	ADJ
admet-796	56	36	q	q	ADJ
admet-796	56	37	water	water	NOUN
admet-796	56	38	:	:	PUNCT
admet-796	56	39	acetonitrile	acetonitrile	NOUN
admet-796	56	40	,	,	PUNCT
admet-796	56	41	20:80	20:80	NUM
admet-796	56	42	,	,	PUNCT
admet-796	56	43	v	v	NOUN
admet-796	56	44	/	/	SYM
admet-796	56	45	v	v	NOUN
admet-796	56	46	)	)	PUNCT
admet-796	56	47	at	at	ADP
admet-796	56	48	a	a	DET
admet-796	56	49	flow	flow	NOUN
admet-796	56	50	-	-	PUNCT
admet-796	56	51	rate	rate	NOUN
admet-796	56	52	of	of	ADP
admet-796	56	53	0.9	0.9	NUM
admet-796	56	54	ml	ml	NOUN
admet-796	56	55	/	/	SYM
admet-796	56	56	min	min	NOUN
admet-796	56	57	was	be	AUX
admet-796	56	58	used	use	VERB
admet-796	56	59	for	for	ADP
admet-796	56	60	separation	separation	NOUN
admet-796	56	61	of	of	ADP
admet-796	56	62	filgotinib	filgotinib	NOUN
admet-796	56	63	and	and	CCONJ
admet-796	56	64	the	the	PRON
admet-796	56	65	is	be	AUX
admet-796	56	66	.	.	PUNCT
admet-796	57	1	the	the	DET
admet-796	57	2	injection	injection	NOUN
admet-796	57	3	volume	volume	NOUN
admet-796	57	4	was	be	AUX
admet-796	57	5	5.0	5.0	NUM
admet-796	57	6	µl	µl	NOUN
admet-796	57	7	.	.	PUNCT
admet-796	58	1	under	under	ADP
admet-796	58	2	these	these	DET
admet-796	58	3	optimized	optimize	VERB
admet-796	58	4	conditions	condition	NOUN
admet-796	58	5	the	the	DET
admet-796	58	6	retention	retention	NOUN
admet-796	58	7	times	time	NOUN
admet-796	58	8	were	be	AUX
admet-796	58	9	1.31	1.31	NUM
admet-796	58	10	and	and	CCONJ
admet-796	58	11	0.89	0.89	NUM
admet-796	58	12	min	min	NOUN
admet-796	58	13	,	,	PUNCT
admet-796	58	14	for	for	ADP
admet-796	58	15	filgotinib	filgotinib	NOUN
admet-796	58	16	and	and	CCONJ
admet-796	58	17	the	the	PRON
admet-796	58	18	is	be	AUX
admet-796	58	19	,	,	PUNCT
admet-796	58	20	respectively	respectively	ADV
admet-796	58	21	with	with	ADP
admet-796	58	22	a	a	DET
admet-796	58	23	total	total	ADJ
admet-796	58	24	run	run	NOUN
admet-796	58	25	time	time	NOUN
admet-796	58	26	of	of	ADP
admet-796	58	27	2.90	2.90	NUM
admet-796	58	28	min	min	NOUN
admet-796	58	29	.	.	PUNCT
admet-796	59	1	the	the	DET
admet-796	59	2	lc	lc	PROPN
admet-796	59	3	was	be	AUX
admet-796	59	4	coupled	couple	VERB
admet-796	59	5	to	to	ADP
admet-796	59	6	a	a	DET
admet-796	59	7	sciex	sciex	NOUN
admet-796	59	8	4000	4000	NUM
admet-796	59	9	mass	mass	NOUN
admet-796	59	10	spectrometer	spectrometer	NOUN
admet-796	59	11	controlled	control	VERB
admet-796	59	12	by	by	ADP
admet-796	59	13	sciex	sciex	NOUN
admet-796	59	14	analyst	analyst	NOUN
admet-796	59	15	1.6.2	1.6.2	NUM
admet-796	59	16	software	software	NOUN
admet-796	59	17	.	.	PUNCT
admet-796	60	1	the	the	DET
admet-796	60	2	ms	ms	PROPN
admet-796	60	3	was	be	AUX
admet-796	60	4	equipped	equip	VERB
admet-796	60	5	with	with	ADP
admet-796	60	6	electro	electro	NOUN
admet-796	60	7	-	-	PUNCT
admet-796	60	8	spray	spray	NOUN
admet-796	60	9	ionization	ionization	NOUN
admet-796	60	10	and	and	CCONJ
admet-796	60	11	operated	operate	VERB
admet-796	60	12	in	in	ADP
admet-796	60	13	the	the	DET
admet-796	60	14	multiple	multiple	ADJ
admet-796	60	15	reaction	reaction	NOUN
admet-796	60	16	monitoring	monitoring	NOUN
admet-796	60	17	(	(	PUNCT
admet-796	60	18	mrm	mrm	PROPN
admet-796	60	19	)	)	PUNCT
admet-796	60	20	mode	mode	NOUN
admet-796	60	21	for	for	ADP
admet-796	60	22	the	the	DET
admet-796	60	23	quantitation	quantitation	NOUN
admet-796	60	24	.	.	PUNCT
admet-796	61	1	ionization	ionization	NOUN
admet-796	61	2	was	be	AUX
admet-796	61	3	conducted	conduct	VERB
admet-796	61	4	by	by	ADP
admet-796	61	5	applying	apply	VERB
admet-796	61	6	a	a	DET
admet-796	61	7	voltage	voltage	NOUN
admet-796	61	8	of	of	ADP
admet-796	61	9	5500	5500	NUM
admet-796	61	10	v	v	NOUN
admet-796	61	11	,	,	PUNCT
admet-796	61	12	and	and	CCONJ
admet-796	61	13	the	the	DET
admet-796	61	14	source	source	NOUN
admet-796	61	15	temperature	temperature	NOUN
admet-796	61	16	was	be	AUX
admet-796	61	17	set	set	VERB
admet-796	61	18	at	at	ADP
admet-796	61	19	550	550	NUM
admet-796	61	20	°	°	NOUN
admet-796	61	21	c	c	NOUN
admet-796	61	22	.	.	PUNCT
admet-796	62	1	the	the	DET
admet-796	62	2	gas	gas	NOUN
admet-796	62	3	settings	setting	NOUN
admet-796	62	4	were	be	AUX
admet-796	62	5	as	as	SCONJ
admet-796	62	6	follows	follow	VERB
admet-796	62	7	curtain	curtain	NOUN
admet-796	62	8	gas	gas	NOUN
admet-796	62	9	:	:	PUNCT
admet-796	62	10	35	35	NUM
admet-796	62	11	psi	psi	NOUN
admet-796	62	12	,	,	PUNCT
admet-796	62	13	gs1	gs1	NOUN
admet-796	62	14	:	:	PUNCT
admet-796	62	15	50	50	NUM
admet-796	62	16	psi	psi	NOUN
admet-796	62	17	,	,	PUNCT
admet-796	62	18	gs2	gs2	NOUN
admet-796	62	19	:	:	PUNCT
admet-796	62	20	55	55	NUM
admet-796	62	21	psi	psi	NOUN
admet-796	62	22	and	and	CCONJ
admet-796	62	23	cad	cad	NOUN
admet-796	62	24	:	:	PUNCT
admet-796	62	25	8.0	8.0	NUM
admet-796	62	26	psi	psi	NOUN
admet-796	62	27	.	.	PUNCT
admet-796	63	1	the	the	DET
admet-796	63	2	compound	compound	NOUN
admet-796	63	3	parameters	parameter	NOUN
admet-796	63	4	declustering	declustere	VERB
admet-796	63	5	potential	potential	ADJ
admet-796	63	6	,	,	PUNCT
admet-796	63	7	entrance	entrance	NOUN
admet-796	63	8	potential	potential	NOUN
admet-796	63	9	,	,	PUNCT
admet-796	63	10	collision	collision	NOUN
admet-796	63	11	energy	energy	NOUN
admet-796	63	12	,	,	PUNCT
admet-796	63	13	and	and	CCONJ
admet-796	63	14	collision	collision	NOUN
admet-796	63	15	cell	cell	NOUN
admet-796	63	16	exit	exit	NOUN
admet-796	63	17	potential	potential	NOUN
admet-796	63	18	were	be	AUX
admet-796	63	19	set	set	VERB
admet-796	63	20	at	at	ADP
admet-796	63	21	91	91	NUM
admet-796	63	22	,	,	PUNCT
admet-796	63	23	10	10	NUM
admet-796	63	24	,	,	PUNCT
admet-796	63	25	40	40	NUM
admet-796	63	26	,	,	PUNCT
admet-796	63	27	and	and	CCONJ
admet-796	63	28	10	10	NUM
admet-796	63	29	v	v	NOUN
admet-796	63	30	for	for	ADP
admet-796	63	31	filgotinib	filgotinib	NOUN
admet-796	63	32	and	and	CCONJ
admet-796	63	33	100	100	NUM
admet-796	63	34	,	,	PUNCT
admet-796	63	35	10	10	NUM
admet-796	63	36	,	,	PUNCT
admet-796	63	37	41	41	NUM
admet-796	63	38	,	,	PUNCT
admet-796	63	39	and	and	CCONJ
admet-796	63	40	12	12	NUM
admet-796	63	41	v	v	NOUN
admet-796	63	42	for	for	ADP
admet-796	63	43	the	the	PRON
admet-796	63	44	is	be	AUX
admet-796	63	45	.	.	PUNCT
admet-796	64	1	the	the	DET
admet-796	64	2	mass	mass	ADJ
admet-796	64	3	transitions	transition	NOUN
admet-796	64	4	m	m	VERB
admet-796	64	5	/	/	SYM
admet-796	64	6	z	z	NOUN
admet-796	64	7	(	(	PUNCT
admet-796	64	8	precursor	precursor	NOUN
admet-796	64	9	ionproduct	ionproduct	NOUN
admet-796	64	10	ion	ion	NOUN
admet-796	64	11	)	)	PUNCT
admet-796	64	12	426.3291.3	426.3291.3	PROPN
admet-796	64	13	and	and	CCONJ
admet-796	64	14	313.2149.2	313.2149.2	PROPN
admet-796	64	15	were	be	AUX
admet-796	64	16	monitored	monitor	VERB
admet-796	64	17	for	for	ADP
admet-796	64	18	filgotinib	filgotinib	NOUN
admet-796	64	19	and	and	CCONJ
admet-796	64	20	the	the	PRON
admet-796	64	21	is	be	AUX
admet-796	64	22	,	,	PUNCT
admet-796	64	23	respectively	respectively	ADV
admet-796	64	24	.	.	PUNCT
admet-796	65	1	quadrupole	quadrupole	PROPN
admet-796	65	2	q1	q1	PROPN
admet-796	65	3	and	and	CCONJ
admet-796	65	4	q3	q3	PROPN
admet-796	65	5	were	be	AUX
admet-796	65	6	set	set	VERB
admet-796	65	7	on	on	ADP
admet-796	65	8	the	the	DET
admet-796	65	9	unit	unit	NOUN
admet-796	65	10	resolution	resolution	NOUN
admet-796	65	11	.	.	PUNCT
admet-796	66	1	dwell	dwell	PROPN
admet-796	66	2	time	time	NOUN
admet-796	66	3	was	be	AUX
admet-796	66	4	150	150	NUM
admet-796	66	5	ms	ms	PROPN
admet-796	66	6	.	.	PROPN
admet-796	66	7	preparation	preparation	NOUN
admet-796	66	8	of	of	ADP
admet-796	66	9	stock	stock	NOUN
admet-796	66	10	solutions	solution	NOUN
admet-796	66	11	and	and	CCONJ
admet-796	66	12	standard	standard	ADJ
admet-796	66	13	samples	sample	NOUN
admet-796	66	14	two	two	NUM
admet-796	66	15	separate	separate	ADJ
admet-796	66	16	primary	primary	ADJ
admet-796	66	17	stock	stock	NOUN
admet-796	66	18	solutions	solution	NOUN
admet-796	66	19	of	of	ADP
admet-796	66	20	filgotinib	filgotinib	NOUN
admet-796	66	21	were	be	AUX
admet-796	66	22	prepared	prepare	VERB
admet-796	66	23	at	at	ADP
admet-796	66	24	1670	1670	NUM
admet-796	66	25	g	g	NOUN
admet-796	66	26	/	/	SYM
admet-796	66	27	ml	ml	X
admet-796	66	28	in	in	ADP
admet-796	66	29	dmso	dmso	NOUN
admet-796	66	30	.	.	PUNCT
admet-796	67	1	appropriate	appropriate	ADJ
admet-796	67	2	secondary	secondary	ADJ
admet-796	67	3	and	and	CCONJ
admet-796	67	4	working	work	VERB
admet-796	67	5	stocks	stock	NOUN
admet-796	67	6	of	of	ADP
admet-796	67	7	filgotinib	filgotinib	NOUN
admet-796	67	8	were	be	AUX
admet-796	67	9	prepared	prepare	VERB
admet-796	67	10	from	from	ADP
admet-796	67	11	primary	primary	ADJ
admet-796	67	12	stock	stock	NOUN
admet-796	67	13	by	by	ADP
admet-796	67	14	successive	successive	ADJ
admet-796	67	15	dilution	dilution	NOUN
admet-796	67	16	of	of	ADP
admet-796	67	17	primary	primary	ADJ
admet-796	67	18	stock	stock	NOUN
admet-796	67	19	with	with	ADP
admet-796	67	20	methanol	methanol	NOUN
admet-796	67	21	:	:	PUNCT
admet-796	67	22	water	water	NOUN
admet-796	67	23	(	(	PUNCT
admet-796	67	24	80:20	80:20	NUM
admet-796	67	25	,	,	PUNCT
admet-796	67	26	v	v	NOUN
admet-796	67	27	/	/	SYM
admet-796	67	28	v	v	NOUN
admet-796	67	29	)	)	PUNCT
admet-796	67	30	to	to	PART
admet-796	67	31	prepare	prepare	VERB
admet-796	67	32	the	the	DET
admet-796	67	33	calibration	calibration	NOUN
admet-796	67	34	curve	curve	NOUN
admet-796	67	35	(	(	PUNCT
admet-796	67	36	cc	cc	NOUN
admet-796	67	37	)	)	PUNCT
admet-796	67	38	and	and	CCONJ
admet-796	67	39	quality	quality	NOUN
admet-796	67	40	controls	control	NOUN
admet-796	67	41	(	(	PUNCT
admet-796	67	42	qcs	qcs	NOUN
admet-796	67	43	)	)	PUNCT
admet-796	67	44	.	.	PUNCT
admet-796	68	1	the	the	PRON
admet-796	68	2	is	be	AUX
admet-796	68	3	primary	primary	ADJ
admet-796	68	4	stock	stock	NOUN
admet-796	68	5	solution	solution	NOUN
admet-796	68	6	was	be	AUX
admet-796	68	7	made	make	VERB
admet-796	68	8	in	in	ADP
admet-796	68	9	dmso	dmso	NOUN
admet-796	68	10	at	at	ADP
admet-796	68	11	a	a	DET
admet-796	68	12	concentration	concentration	NOUN
admet-796	68	13	of	of	ADP
admet-796	68	14	1000	1000	NUM
admet-796	68	15	µg	µg	NOUN
admet-796	68	16	/	/	SYM
admet-796	68	17	ml	ml	NOUN
admet-796	68	18	,	,	PUNCT
admet-796	68	19	which	which	PRON
admet-796	68	20	was	be	AUX
admet-796	68	21	diluted	dilute	VERB
admet-796	68	22	with	with	ADP
admet-796	68	23	methanol	methanol	NOUN
admet-796	68	24	to	to	ADP
admet-796	68	25	500	500	NUM
admet-796	68	26	ng	ng	NOUN
admet-796	68	27	/	/	SYM
admet-796	68	28	ml	ml	PROPN
admet-796	68	29	and	and	CCONJ
admet-796	68	30	subsequently	subsequently	ADV
admet-796	68	31	used	use	VERB
admet-796	68	32	as	as	SCONJ
admet-796	68	33	is	be	AUX
admet-796	68	34	working	work	VERB
admet-796	68	35	stock	stock	NOUN
admet-796	68	36	solution	solution	NOUN
admet-796	68	37	.	.	PUNCT
admet-796	69	1	the	the	DET
admet-796	69	2	primary	primary	ADJ
admet-796	69	3	stock	stock	NOUN
admet-796	69	4	solutions	solution	NOUN
admet-796	69	5	of	of	ADP
admet-796	69	6	filgotinib	filgotinib	NOUN
admet-796	69	7	and	and	CCONJ
admet-796	69	8	the	the	DET
admet-796	69	9	is	be	AUX
admet-796	69	10	were	be	AUX
admet-796	69	11	stored	store	VERB
admet-796	69	12	at	at	ADP
admet-796	69	13	-20	-20	PROPN
admet-796	69	14	°	°	ADP
admet-796	69	15	c	c	NOUN
admet-796	69	16	,	,	PUNCT
admet-796	69	17	which	which	PRON
admet-796	69	18	were	be	AUX
admet-796	69	19	found	find	VERB
admet-796	69	20	to	to	PART
admet-796	69	21	be	be	AUX
admet-796	69	22	stable	stable	ADJ
admet-796	69	23	for	for	ADP
admet-796	69	24	50	50	NUM
admet-796	69	25	days	day	NOUN
admet-796	69	26	.	.	PUNCT
admet-796	70	1	working	work	VERB
admet-796	70	2	stock	stock	NOUN
admet-796	70	3	solutions	solution	NOUN
admet-796	70	4	were	be	AUX
admet-796	70	5	stored	store	VERB
admet-796	70	6	at	at	ADP
admet-796	70	7	4	4	NUM
admet-796	70	8	°	°	ADP
admet-796	70	9	c	c	NOUN
admet-796	70	10	for	for	ADP
admet-796	70	11	25	25	NUM
admet-796	70	12	days	day	NOUN
admet-796	70	13	.	.	PUNCT
admet-796	71	1	blood	blood	NOUN
admet-796	71	2	spotting	spot	VERB
admet-796	71	3	freshly	freshly	ADV
admet-796	71	4	drawn	draw	VERB
admet-796	71	5	rat	rat	NOUN
admet-796	71	6	blood	blood	NOUN
admet-796	71	7	was	be	AUX
admet-796	71	8	used	use	VERB
admet-796	71	9	to	to	PART
admet-796	71	10	prepare	prepare	VERB
admet-796	71	11	the	the	DET
admet-796	71	12	dbs	dbs	PROPN
admet-796	71	13	cards	card	NOUN
admet-796	71	14	.	.	PUNCT
admet-796	72	1	with	with	ADP
admet-796	72	2	the	the	DET
admet-796	72	3	help	help	NOUN
admet-796	72	4	of	of	ADP
admet-796	72	5	a	a	DET
admet-796	72	6	calibrated	calibrate	VERB
admet-796	72	7	pipette	pipette	NOUN
admet-796	72	8	,	,	PUNCT
admet-796	72	9	25	25	NUM
admet-796	72	10	μl	μl	ADP
admet-796	72	11	of	of	ADP
admet-796	72	12	the	the	DET
admet-796	72	13	respective	respective	ADJ
admet-796	72	14	spiked	spiked	ADJ
admet-796	72	15	cc	cc	PROPN
admet-796	72	16	/	/	SYM
admet-796	72	17	qc	qc	PROPN
admet-796	72	18	blood	blood	NOUN
admet-796	72	19	or	or	CCONJ
admet-796	72	20	whole	whole	ADJ
admet-796	72	21	blood	blood	NOUN
admet-796	72	22	collected	collect	VERB
admet-796	72	23	from	from	ADP
admet-796	72	24	the	the	DET
admet-796	72	25	pharmacokinetic	pharmacokinetic	ADJ
admet-796	72	26	study	study	NOUN
admet-796	72	27	(	(	PUNCT
admet-796	72	28	post	post	PROPN
admet-796	72	29	administration	administration	NOUN
admet-796	72	30	of	of	ADP
admet-796	72	31	filgotinib	filgotinib	NOUN
admet-796	72	32	by	by	ADP
admet-796	72	33	intravenous	intravenous	ADJ
admet-796	72	34	and	and	CCONJ
admet-796	72	35	oral	oral	ADJ
admet-796	72	36	routes	route	NOUN
admet-796	72	37	)	)	PUNCT
admet-796	72	38	was	be	AUX
admet-796	72	39	sampled	sample	VERB
admet-796	72	40	on	on	ADP
admet-796	72	41	dbs	dbs	PROPN
admet-796	72	42	card	card	NOUN
admet-796	72	43	.	.	PUNCT
admet-796	73	1	spiked	spiked	ADJ
admet-796	73	2	cards	card	NOUN
admet-796	73	3	were	be	AUX
admet-796	73	4	allowed	allow	VERB
admet-796	73	5	to	to	PART
admet-796	73	6	dry	dry	VERB
admet-796	73	7	at	at	ADP
admet-796	73	8	ambient	ambient	ADJ
admet-796	73	9	room	room	NOUN
admet-796	73	10	temperature	temperature	NOUN
admet-796	73	11	for	for	ADP
admet-796	73	12	3	3	NUM
admet-796	73	13	h	h	NOUN
admet-796	73	14	and	and	CCONJ
admet-796	73	15	stored	store	VERB
admet-796	73	16	appropriately	appropriately	ADV
admet-796	73	17	in	in	ADP
admet-796	73	18	a	a	DET
admet-796	73	19	sealed	seal	VERB
admet-796	73	20	bag	bag	NOUN
admet-796	73	21	with	with	ADP
admet-796	73	22	desiccant	desiccant	NOUN
admet-796	73	23	in	in	ADP
admet-796	73	24	a	a	DET
admet-796	73	25	desiccator	desiccator	NOUN
admet-796	73	26	.	.	PUNCT
admet-796	74	1	dbs	dbs	PROPN
admet-796	74	2	homogeneity	homogeneity	NOUN
admet-796	74	3	the	the	DET
admet-796	74	4	spot	spot	NOUN
admet-796	74	5	homogeneity	homogeneity	NOUN
admet-796	74	6	was	be	AUX
admet-796	74	7	evaluated	evaluate	VERB
admet-796	74	8	by	by	ADP
admet-796	74	9	punching	punch	VERB
admet-796	74	10	out	out	ADP
admet-796	74	11	the	the	DET
admet-796	74	12	disc	disc	NOUN
admet-796	74	13	from	from	ADP
admet-796	74	14	the	the	DET
admet-796	74	15	periphery	periphery	NOUN
admet-796	74	16	of	of	ADP
admet-796	74	17	the	the	DET
admet-796	74	18	dbs	dbs	PROPN
admet-796	74	19	.	.	PUNCT
admet-796	75	1	blood	blood	NOUN
admet-796	75	2	spots	spot	NOUN
admet-796	75	3	at	at	ADP
admet-796	75	4	qc	qc	PROPN
admet-796	75	5	low	low	PROPN
admet-796	75	6	and	and	CCONJ
admet-796	75	7	qc	qc	PROPN
admet-796	75	8	high	high	ADJ
admet-796	75	9	level	level	NOUN
admet-796	75	10	were	be	AUX
admet-796	75	11	prepared	prepare	VERB
admet-796	75	12	in	in	ADP
admet-796	75	13	triplicate	triplicate	NOUN
admet-796	75	14	.	.	PUNCT
admet-796	76	1	the	the	DET
admet-796	76	2	obtained	obtain	VERB
admet-796	76	3	dbs	dbs	PROPN
admet-796	76	4	discs	disc	NOUN
admet-796	76	5	were	be	AUX
admet-796	76	6	processed	process	VERB
admet-796	76	7	and	and	CCONJ
admet-796	76	8	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PROPN
admet-796	76	9	r.	r.	PROPN
admet-796	76	10	mullangi	mullangi	PROPN
admet-796	76	11	et	et	PROPN
admet-796	76	12	al	al	PROPN
admet-796	76	13	.	.	PROPN
admet-796	76	14	admet	admet	PROPN
admet-796	76	15	&	&	CCONJ
admet-796	76	16	dmpk	dmpk	PROPN
admet-796	76	17	8(2	8(2	NUM
admet-796	76	18	)	)	PUNCT
admet-796	76	19	(	(	PUNCT
admet-796	76	20	2020	2020	NUM
admet-796	76	21	)	)	PUNCT
admet-796	76	22	139	139	NUM
admet-796	76	23	-	-	SYM
admet-796	76	24	148	148	NUM
admet-796	76	25	142	142	NUM
admet-796	76	26	analyzed	analyze	VERB
admet-796	76	27	as	as	SCONJ
admet-796	76	28	described	describe	VERB
admet-796	76	29	in	in	ADP
admet-796	76	30	the	the	DET
admet-796	76	31	sample	sample	NOUN
admet-796	76	32	preparation	preparation	NOUN
admet-796	76	33	section	section	NOUN
admet-796	76	34	.	.	PUNCT
admet-796	77	1	dbs	dbs	PROPN
admet-796	77	2	sample	sample	NOUN
admet-796	77	3	preparations	preparation	NOUN
admet-796	77	4	using	use	VERB
admet-796	77	5	a	a	DET
admet-796	77	6	hole	hole	NOUN
admet-796	77	7	puncher	puncher	NOUN
admet-796	77	8	(	(	PUNCT
admet-796	77	9	harri	harri	NOUN
admet-796	77	10	-	-	PUNCT
admet-796	77	11	micro	micro	NOUN
admet-796	77	12	-	-	ADJ
admet-796	77	13	punch	punch	ADJ
admet-796	77	14	®	®	NOUN
admet-796	77	15	)	)	PUNCT
admet-796	77	16	,	,	PUNCT
admet-796	77	17	3	3	NUM
admet-796	77	18	mm	mm	NOUN
admet-796	77	19	diameter	diameter	NOUN
admet-796	77	20	disc	disc	NOUN
admet-796	77	21	was	be	AUX
admet-796	77	22	punched	punch	VERB
admet-796	77	23	from	from	ADP
admet-796	77	24	the	the	DET
admet-796	77	25	center	center	NOUN
admet-796	77	26	of	of	ADP
admet-796	77	27	each	each	DET
admet-796	77	28	dbs	dbs	NOUN
admet-796	77	29	(	(	PUNCT
admet-796	77	30	fta	fta	PROPN
admet-796	77	31	dmpk	dmpk	PROPN
admet-796	77	32	-	-	PUNCT
admet-796	77	33	c	c	NOUN
admet-796	77	34	card	card	NOUN
admet-796	77	35	)	)	PUNCT
admet-796	77	36	card	card	NOUN
admet-796	77	37	directly	directly	ADV
admet-796	77	38	into	into	ADP
admet-796	77	39	micro	micro	NOUN
admet-796	77	40	-	-	NOUN
admet-796	77	41	centrifuge	centrifuge	ADJ
admet-796	77	42	tubes	tube	NOUN
admet-796	77	43	.	.	PUNCT
admet-796	78	1	to	to	ADP
admet-796	78	2	each	each	DET
admet-796	78	3	micro	micro	NOUN
admet-796	78	4	-	-	NOUN
admet-796	78	5	centrifuge	centrifuge	ADJ
admet-796	78	6	tube	tube	NOUN
admet-796	78	7	,	,	PUNCT
admet-796	78	8	200	200	NUM
admet-796	78	9	µl	µl	NOUN
admet-796	78	10	of	of	ADP
admet-796	78	11	0.2	0.2	NUM
admet-796	78	12	%	%	NOUN
admet-796	78	13	formic	formic	PROPN
admet-796	78	14	acid	acid	NOUN
admet-796	78	15	enriched	enrich	VERB
admet-796	78	16	with	with	ADP
admet-796	78	17	100	100	NUM
admet-796	78	18	ng	ng	NOUN
admet-796	78	19	/	/	SYM
admet-796	78	20	ml	ml	X
admet-796	78	21	of	of	ADP
admet-796	78	22	is	be	AUX
admet-796	78	23	was	be	AUX
admet-796	78	24	added	add	VERB
admet-796	78	25	,	,	PUNCT
admet-796	78	26	thereafter	thereafter	ADV
admet-796	78	27	the	the	DET
admet-796	78	28	contents	content	NOUN
admet-796	78	29	were	be	AUX
admet-796	78	30	vortex	vortex	NOUN
admet-796	78	31	mixed	mix	VERB
admet-796	78	32	for	for	ADP
admet-796	78	33	5	5	NUM
admet-796	78	34	min	min	NOUN
admet-796	78	35	(	(	PUNCT
admet-796	78	36	thermomixer	thermomixer	PRON
admet-796	78	37	®	®	NOUN
admet-796	78	38	,	,	PUNCT
admet-796	78	39	eppendorf	eppendorf	PROPN
admet-796	78	40	)	)	PUNCT
admet-796	78	41	and	and	CCONJ
admet-796	78	42	sonicated	sonicate	VERB
admet-796	78	43	(	(	PUNCT
admet-796	78	44	elmasonic	elmasonic	ADJ
admet-796	78	45	s300	s300	PROPN
admet-796	78	46	h	h	NOUN
admet-796	78	47	)	)	PUNCT
admet-796	78	48	for	for	ADP
admet-796	78	49	15	15	NUM
admet-796	78	50	min	min	NOUN
admet-796	78	51	at	at	ADP
admet-796	78	52	ambient	ambient	ADJ
admet-796	78	53	room	room	NOUN
admet-796	78	54	temperature	temperature	NOUN
admet-796	78	55	.	.	PUNCT
admet-796	79	1	after	after	ADP
admet-796	79	2	sonication	sonication	NOUN
admet-796	79	3	,	,	PUNCT
admet-796	79	4	to	to	ADP
admet-796	79	5	the	the	DET
admet-796	79	6	same	same	ADJ
admet-796	79	7	micro	micro	NOUN
admet-796	79	8	-	-	NOUN
admet-796	79	9	centrifuge	centrifuge	NOUN
admet-796	79	10	,	,	PUNCT
admet-796	79	11	1.0	1.0	NUM
admet-796	79	12	ml	ml	NOUN
admet-796	79	13	of	of	ADP
admet-796	79	14	ethyl	ethyl	PROPN
admet-796	79	15	acetate	acetate	PROPN
admet-796	79	16	was	be	AUX
admet-796	79	17	added	add	VERB
admet-796	79	18	and	and	CCONJ
admet-796	79	19	the	the	DET
admet-796	79	20	mixtures	mixture	NOUN
admet-796	79	21	were	be	AUX
admet-796	79	22	vortexed	vortexe	VERB
admet-796	79	23	further	far	ADV
admet-796	79	24	for	for	ADP
admet-796	79	25	3	3	NUM
admet-796	79	26	min	min	NOUN
admet-796	79	27	.	.	PUNCT
admet-796	80	1	the	the	DET
admet-796	80	2	samples	sample	NOUN
admet-796	80	3	were	be	AUX
admet-796	80	4	centrifuged	centrifuge	VERB
admet-796	80	5	at	at	ADP
admet-796	80	6	14,000	14,000	NUM
admet-796	80	7	rpm	rpm	NOUN
admet-796	80	8	for	for	ADP
admet-796	80	9	3	3	NUM
admet-796	80	10	min	min	NOUN
admet-796	80	11	.	.	PROPN
admet-796	80	12	clear	clear	ADJ
admet-796	80	13	organic	organic	ADJ
admet-796	80	14	layer	layer	NOUN
admet-796	80	15	(	(	PUNCT
admet-796	80	16	800	800	NUM
admet-796	80	17	µl	µl	NOUN
admet-796	80	18	)	)	PUNCT
admet-796	80	19	was	be	AUX
admet-796	80	20	pipetted	pipette	VERB
admet-796	80	21	out	out	ADP
admet-796	80	22	after	after	ADP
admet-796	80	23	centrifugation	centrifugation	NOUN
admet-796	80	24	and	and	CCONJ
admet-796	80	25	dried	dry	VERB
admet-796	80	26	under	under	ADP
admet-796	80	27	gentle	gentle	ADJ
admet-796	80	28	stream	stream	NOUN
admet-796	80	29	of	of	ADP
admet-796	80	30	nitrogen	nitrogen	NOUN
admet-796	80	31	(	(	PUNCT
admet-796	80	32	turbovap	turbovap	NOUN
admet-796	80	33	®	®	NOUN
admet-796	80	34	,	,	PUNCT
admet-796	80	35	zymark	zymark	NOUN
admet-796	80	36	®	®	NOUN
admet-796	80	37	,	,	PUNCT
admet-796	80	38	kopkinton	kopkinton	PROPN
admet-796	80	39	,	,	PUNCT
admet-796	80	40	ma	ma	PROPN
admet-796	80	41	,	,	PUNCT
admet-796	80	42	usa	usa	PROPN
admet-796	80	43	)	)	PUNCT
admet-796	80	44	at	at	ADP
admet-796	80	45	50	50	NUM
admet-796	80	46	°	°	NOUN
admet-796	80	47	c	c	NOUN
admet-796	80	48	.	.	PUNCT
admet-796	81	1	the	the	DET
admet-796	81	2	residue	residue	NOUN
admet-796	81	3	was	be	AUX
admet-796	81	4	reconstituted	reconstitute	VERB
admet-796	81	5	with	with	ADP
admet-796	81	6	200	200	NUM
admet-796	81	7	µl	µl	NOUN
admet-796	81	8	of	of	ADP
admet-796	81	9	0.2	0.2	NUM
admet-796	81	10	%	%	NOUN
admet-796	81	11	formic	formic	ADJ
admet-796	81	12	acid	acid	NOUN
admet-796	81	13	in	in	ADP
admet-796	81	14	acetonitrile	acetonitrile	NOUN
admet-796	81	15	and	and	CCONJ
admet-796	81	16	150	150	NUM
admet-796	81	17	µl	µl	ADP
admet-796	81	18	clear	clear	ADJ
admet-796	81	19	supernatant	supernatant	NOUN
admet-796	81	20	was	be	AUX
admet-796	81	21	aliquoted	aliquote	VERB
admet-796	81	22	into	into	ADP
admet-796	81	23	a	a	DET
admet-796	81	24	hplc	hplc	NOUN
admet-796	81	25	vial	vial	ADJ
admet-796	81	26	and	and	CCONJ
admet-796	81	27	5.0	5.0	NUM
admet-796	81	28	µl	µl	NOUN
admet-796	81	29	was	be	AUX
admet-796	81	30	injected	inject	VERB
admet-796	81	31	onto	onto	ADP
admet-796	81	32	the	the	DET
admet-796	81	33	column	column	NOUN
admet-796	81	34	for	for	ADP
admet-796	81	35	lc	lc	PROPN
admet-796	81	36	-	-	PUNCT
admet-796	81	37	ms	ms	PROPN
admet-796	81	38	/	/	SYM
admet-796	81	39	ms	ms	NOUN
admet-796	81	40	analysis	analysis	NOUN
admet-796	81	41	.	.	PUNCT
admet-796	82	1	validation	validation	NOUN
admet-796	82	2	procedure	procedure	NOUN
admet-796	82	3	the	the	DET
admet-796	82	4	validation	validation	NOUN
admet-796	82	5	experiments	experiment	NOUN
admet-796	82	6	were	be	AUX
admet-796	82	7	performed	perform	VERB
admet-796	82	8	in	in	ADP
admet-796	82	9	accordance	accordance	NOUN
admet-796	82	10	with	with	ADP
admet-796	82	11	the	the	DET
admet-796	82	12	us	us	PROPN
admet-796	82	13	food	food	NOUN
admet-796	82	14	and	and	CCONJ
admet-796	82	15	drug	drug	PROPN
admet-796	82	16	administration	administration	PROPN
admet-796	82	17	guideline	guideline	NOUN
admet-796	83	1	[	[	X
admet-796	83	2	17	17	NUM
admet-796	83	3	]	]	PUNCT
admet-796	83	4	.	.	PUNCT
admet-796	84	1	various	various	ADJ
admet-796	84	2	parameters	parameter	NOUN
admet-796	84	3	covered	cover	VERB
admet-796	84	4	under	under	ADP
admet-796	84	5	validation	validation	NOUN
admet-796	84	6	are	be	AUX
admet-796	84	7	:	:	PUNCT
admet-796	84	8	selectivity	selectivity	NOUN
admet-796	84	9	,	,	PUNCT
admet-796	84	10	carry	carry	VERB
admet-796	84	11	over	over	ADP
admet-796	84	12	(	(	PUNCT
admet-796	84	13	repetitive	repetitive	ADJ
admet-796	84	14	punching	punching	NOUN
admet-796	84	15	and	and	CCONJ
admet-796	84	16	auto	auto	NOUN
admet-796	84	17	-	-	PUNCT
admet-796	84	18	injector	injector	NOUN
admet-796	84	19	)	)	PUNCT
admet-796	84	20	,	,	PUNCT
admet-796	84	21	recovery	recovery	NOUN
admet-796	84	22	,	,	PUNCT
admet-796	84	23	matrix	matrix	NOUN
admet-796	84	24	effect	effect	NOUN
admet-796	84	25	,	,	PUNCT
admet-796	84	26	linearity	linearity	NOUN
admet-796	84	27	,	,	PUNCT
admet-796	84	28	precision	precision	NOUN
admet-796	84	29	,	,	PUNCT
admet-796	84	30	accuracy	accuracy	NOUN
admet-796	84	31	,	,	PUNCT
admet-796	84	32	stability	stability	NOUN
admet-796	84	33	(	(	PUNCT
admet-796	84	34	in	in	ADP
admet-796	84	35	-	-	PUNCT
admet-796	84	36	injector	injector	NOUN
admet-796	84	37	,	,	PUNCT
admet-796	84	38	6	6	NUM
admet-796	84	39	h	h	NOUN
admet-796	84	40	at	at	ADP
admet-796	84	41	room	room	NOUN
admet-796	84	42	temperature	temperature	NOUN
admet-796	84	43	and	and	CCONJ
admet-796	84	44	30	30	NUM
admet-796	84	45	-	-	PUNCT
admet-796	84	46	day	day	NOUN
admet-796	84	47	long	long	ADJ
admet-796	84	48	-	-	PUNCT
admet-796	84	49	term	term	NOUN
admet-796	84	50	at	at	ADP
admet-796	84	51	-80	-80	PUNCT
admet-796	84	52	±	±	NUM
admet-796	84	53	10	10	NUM
admet-796	84	54	°	°	NOUN
admet-796	84	55	c	c	NOUN
admet-796	84	56	)	)	PUNCT
admet-796	84	57	and	and	CCONJ
admet-796	84	58	incurred	incur	VERB
admet-796	84	59	sample	sample	NOUN
admet-796	84	60	reanalysis	reanalysis	NOUN
admet-796	84	61	.	.	PUNCT
admet-796	85	1	influence	influence	NOUN
admet-796	85	2	of	of	ADP
admet-796	85	3	hematocrit	hematocrit	PROPN
admet-796	85	4	two	two	NUM
admet-796	85	5	different	different	ADJ
admet-796	85	6	hematocrit	hematocrit	NOUN
admet-796	85	7	(	(	PUNCT
admet-796	85	8	hct	hct	NOUN
admet-796	85	9	)	)	PUNCT
admet-796	85	10	blood	blood	NOUN
admet-796	85	11	samples	sample	NOUN
admet-796	85	12	at	at	ADP
admet-796	85	13	30	30	NUM
admet-796	85	14	and	and	CCONJ
admet-796	85	15	50	50	NUM
admet-796	85	16	%	%	NOUN
admet-796	85	17	were	be	AUX
admet-796	85	18	prepared	prepare	VERB
admet-796	85	19	at	at	ADP
admet-796	85	20	lqc	lqc	NOUN
admet-796	85	21	and	and	CCONJ
admet-796	85	22	hqc	hqc	INTJ
admet-796	85	23	by	by	ADP
admet-796	85	24	adding	add	VERB
admet-796	85	25	or	or	CCONJ
admet-796	85	26	removing	remove	VERB
admet-796	85	27	the	the	DET
admet-796	85	28	plasma	plasma	NOUN
admet-796	85	29	to	to	ADP
admet-796	85	30	the	the	DET
admet-796	85	31	rat	rat	NOUN
admet-796	85	32	blood	blood	NOUN
admet-796	85	33	.	.	PUNCT
admet-796	86	1	these	these	DET
admet-796	86	2	samples	sample	NOUN
admet-796	86	3	(	(	PUNCT
admet-796	86	4	in	in	ADP
admet-796	86	5	quadruplicate	quadruplicate	NOUN
admet-796	86	6	at	at	ADP
admet-796	86	7	each	each	DET
admet-796	86	8	qc	qc	PROPN
admet-796	86	9	)	)	PUNCT
admet-796	86	10	were	be	AUX
admet-796	86	11	analysed	analyse	VERB
admet-796	86	12	with	with	ADP
admet-796	86	13	calibrators	calibrator	NOUN
admet-796	86	14	prepared	prepare	VERB
admet-796	86	15	in	in	ADP
admet-796	86	16	blood	blood	NOUN
admet-796	86	17	at	at	ADP
admet-796	86	18	standard	standard	ADJ
admet-796	86	19	fixed	fix	VERB
admet-796	86	20	40	40	NUM
admet-796	86	21	%	%	NOUN
admet-796	86	22	hct	hct	PROPN
admet-796	86	23	.	.	PUNCT
admet-796	87	1	the	the	DET
admet-796	87	2	relative	relative	ADJ
admet-796	87	3	error	error	NOUN
admet-796	87	4	of	of	ADP
admet-796	87	5	±15	±15	NOUN
admet-796	87	6	%	%	NOUN
admet-796	87	7	and	and	CCONJ
admet-796	87	8	precision	precision	NOUN
admet-796	87	9	of	of	ADP
admet-796	87	10	±15	±15	NOUN
admet-796	87	11	%	%	NOUN
admet-796	87	12	was	be	AUX
admet-796	87	13	considered	consider	VERB
admet-796	87	14	acceptable	acceptable	ADJ
admet-796	87	15	.	.	PUNCT
admet-796	88	1	hct	hct	NOUN
admet-796	88	2	value	value	NOUN
admet-796	88	3	in	in	ADP
admet-796	88	4	rats	rat	NOUN
admet-796	88	5	ranged	range	VERB
admet-796	88	6	between	between	ADP
admet-796	88	7	38	38	NUM
admet-796	88	8	-	-	SYM
admet-796	88	9	46	46	NUM
admet-796	88	10	%	%	NOUN
admet-796	88	11	(	(	PUNCT
admet-796	88	12	in	in	ADP
admet-796	88	13	-	-	PUNCT
admet-796	88	14	house	house	NOUN
admet-796	88	15	data	datum	NOUN
admet-796	88	16	;	;	PUNCT
admet-796	88	17	measured	measure	VERB
admet-796	88	18	using	use	VERB
admet-796	88	19	mindray	mindray	NOUN
admet-796	88	20	bc-5000vet	bc-5000vet	NOUN
admet-796	88	21	)	)	PUNCT
admet-796	88	22	and	and	CCONJ
admet-796	88	23	it	it	PRON
admet-796	88	24	is	be	AUX
admet-796	88	25	in	in	ADP
admet-796	88	26	line	line	NOUN
admet-796	88	27	with	with	ADP
admet-796	88	28	reported	report	VERB
admet-796	88	29	values	value	NOUN
admet-796	88	30	[	[	X
admet-796	88	31	18	18	NUM
admet-796	88	32	]	]	PUNCT
admet-796	88	33	.	.	PUNCT
admet-796	89	1	pharmacokinetic	pharmacokinetic	ADJ
admet-796	89	2	study	study	NOUN
admet-796	89	3	in	in	ADP
admet-796	89	4	rats	rat	NOUN
admet-796	89	5	all	all	DET
admet-796	89	6	the	the	DET
admet-796	89	7	animal	animal	NOUN
admet-796	89	8	experiments	experiment	NOUN
admet-796	89	9	were	be	AUX
admet-796	89	10	approved	approve	VERB
admet-796	89	11	by	by	ADP
admet-796	89	12	institutional	institutional	ADJ
admet-796	89	13	animal	animal	NOUN
admet-796	89	14	ethical	ethical	PROPN
admet-796	89	15	committee	committee	NOUN
admet-796	89	16	(	(	PUNCT
admet-796	89	17	iaec	iaec	NOUN
admet-796	89	18	/	/	SYM
admet-796	89	19	jdc/2019/189r	jdc/2019/189r	PROPN
admet-796	89	20	)	)	PUNCT
admet-796	89	21	.	.	PUNCT
admet-796	90	1	male	male	ADJ
admet-796	90	2	sprague	sprague	PROPN
admet-796	90	3	dawley	dawley	NOUN
admet-796	90	4	rats	rat	NOUN
admet-796	90	5	(	(	PUNCT
admet-796	90	6	n=8	n=8	NUM
admet-796	90	7	)	)	PUNCT
admet-796	90	8	were	be	AUX
admet-796	90	9	procured	procure	VERB
admet-796	90	10	from	from	ADP
admet-796	90	11	vivo	vivo	ADJ
admet-796	90	12	biotech	biotech	NOUN
admet-796	90	13	,	,	PUNCT
admet-796	90	14	hyderabad	hyderabad	PROPN
admet-796	90	15	,	,	PUNCT
admet-796	90	16	india	india	PROPN
admet-796	90	17	.	.	PUNCT
admet-796	91	1	the	the	DET
admet-796	91	2	animals	animal	NOUN
admet-796	91	3	were	be	AUX
admet-796	91	4	housed	house	VERB
admet-796	91	5	in	in	ADP
admet-796	91	6	jubilant	jubilant	ADJ
admet-796	91	7	biosys	biosys	NOUN
admet-796	91	8	animal	animal	PROPN
admet-796	91	9	house	house	NOUN
admet-796	91	10	facility	facility	NOUN
admet-796	91	11	in	in	ADP
admet-796	91	12	a	a	DET
admet-796	91	13	temperature	temperature	NOUN
admet-796	91	14	(	(	PUNCT
admet-796	91	15	22	22	NUM
admet-796	91	16	±	±	NUM
admet-796	91	17	2	2	NUM
admet-796	91	18	°	°	ADP
admet-796	91	19	c	c	NOUN
admet-796	91	20	)	)	PUNCT
admet-796	91	21	and	and	CCONJ
admet-796	91	22	humidity	humidity	NOUN
admet-796	91	23	(	(	PUNCT
admet-796	91	24	30	30	NUM
admet-796	91	25	-	-	SYM
admet-796	91	26	70	70	NUM
admet-796	91	27	%	%	NOUN
admet-796	91	28	)	)	PUNCT
admet-796	91	29	controlled	control	VERB
admet-796	91	30	room	room	NOUN
admet-796	91	31	(	(	PUNCT
admet-796	91	32	15	15	NUM
admet-796	91	33	air	air	NOUN
admet-796	91	34	changes	change	NOUN
admet-796	91	35	/	/	SYM
admet-796	91	36	hour	hour	NOUN
admet-796	91	37	)	)	PUNCT
admet-796	91	38	with	with	ADP
admet-796	91	39	a	a	DET
admet-796	91	40	12:12	12:12	NUM
admet-796	91	41	h	h	NOUN
admet-796	91	42	light	light	NOUN
admet-796	91	43	:	:	PUNCT
admet-796	91	44	dark	dark	ADJ
admet-796	91	45	cycles	cycle	NOUN
admet-796	91	46	,	,	PUNCT
admet-796	91	47	had	have	VERB
admet-796	91	48	free	free	ADJ
admet-796	91	49	access	access	NOUN
admet-796	91	50	to	to	ADP
admet-796	91	51	rodent	rodent	ADJ
admet-796	91	52	feed	feed	NOUN
admet-796	91	53	(	(	PUNCT
admet-796	91	54	altromin	altromin	NOUN
admet-796	91	55	spezialfutter	spezialfutter	PROPN
admet-796	91	56	gmbh	gmbh	PROPN
admet-796	91	57	&	&	CCONJ
admet-796	91	58	co.	co.	PROPN
admet-796	92	1	kg	kg	PROPN
admet-796	92	2	.	.	PROPN
admet-796	92	3	,	,	PUNCT
admet-796	93	1	i	i	PRON
admet-796	93	2	m	m	VERB
admet-796	93	3	seelenkamp	seelenkamp	ADJ
admet-796	93	4	20	20	NUM
admet-796	93	5	,	,	PUNCT
admet-796	93	6	d-32791	d-32791	PROPN
admet-796	93	7	,	,	PUNCT
admet-796	93	8	lage	lage	NOUN
admet-796	93	9	,	,	PUNCT
admet-796	93	10	germany	germany	PROPN
admet-796	93	11	)	)	PUNCT
admet-796	93	12	and	and	CCONJ
admet-796	93	13	water	water	NOUN
admet-796	93	14	for	for	ADP
admet-796	93	15	one	one	NUM
admet-796	93	16	week	week	NOUN
admet-796	93	17	before	before	ADP
admet-796	93	18	using	use	VERB
admet-796	93	19	for	for	ADP
admet-796	93	20	experimental	experimental	ADJ
admet-796	93	21	purpose	purpose	NOUN
admet-796	93	22	.	.	PUNCT
admet-796	94	1	following	follow	VERB
admet-796	94	2	~12	~12	NUM
admet-796	94	3	h	h	NOUN
admet-796	94	4	fast	fast	ADV
admet-796	94	5	(	(	PUNCT
admet-796	94	6	during	during	ADP
admet-796	94	7	the	the	DET
admet-796	94	8	fasting	fast	VERB
admet-796	94	9	period	period	NOUN
admet-796	94	10	animals	animal	NOUN
admet-796	94	11	had	have	VERB
admet-796	94	12	free	free	ADJ
admet-796	94	13	access	access	NOUN
admet-796	94	14	to	to	ADP
admet-796	94	15	water	water	NOUN
admet-796	94	16	)	)	PUNCT
admet-796	94	17	animals	animal	NOUN
admet-796	94	18	were	be	AUX
admet-796	94	19	divided	divide	VERB
admet-796	94	20	into	into	ADP
admet-796	94	21	two	two	NUM
admet-796	94	22	groups	group	NOUN
admet-796	94	23	having	have	VERB
admet-796	94	24	four	four	NUM
admet-796	94	25	rats	rat	NOUN
admet-796	94	26	in	in	ADP
admet-796	94	27	each	each	DET
admet-796	94	28	group	group	NOUN
admet-796	94	29	.	.	PUNCT
admet-796	95	1	group	group	NOUN
admet-796	95	2	i	i	PRON
admet-796	95	3	animals	animal	NOUN
admet-796	95	4	(	(	PUNCT
admet-796	95	5	205	205	NUM
admet-796	95	6	-	-	SYM
admet-796	95	7	210	210	NUM
admet-796	95	8	)	)	PUNCT
admet-796	95	9	received	receive	VERB
admet-796	95	10	filgotinib	filgotinib	NOUN
admet-796	95	11	orally	orally	ADV
admet-796	95	12	as	as	ADP
admet-796	95	13	a	a	DET
admet-796	95	14	suspension	suspension	NOUN
admet-796	95	15	formulation	formulation	NOUN
admet-796	95	16	(	(	PUNCT
admet-796	95	17	prepared	prepare	VERB
admet-796	95	18	using	use	VERB
admet-796	95	19	tween-80	tween-80	NUM
admet-796	95	20	and	and	CCONJ
admet-796	95	21	0.5	0.5	NUM
admet-796	95	22	%	%	NOUN
admet-796	95	23	methyl	methyl	NOUN
admet-796	95	24	cellulose	cellulose	NOUN
admet-796	95	25	)	)	PUNCT
admet-796	95	26	at	at	ADP
admet-796	95	27	10	10	NUM
admet-796	95	28	mg	mg	PROPN
admet-796	95	29	/	/	SYM
admet-796	95	30	kg	kg	PROPN
admet-796	95	31	(	(	PUNCT
admet-796	95	32	strength	strength	NOUN
admet-796	95	33	:	:	PUNCT
admet-796	95	34	1.0	1.0	NUM
admet-796	95	35	mg	mg	NUM
admet-796	95	36	/	/	SYM
admet-796	95	37	ml	ml	PROPN
admet-796	95	38	;	;	PUNCT
admet-796	95	39	dose	dose	NOUN
admet-796	95	40	volume	volume	NOUN
admet-796	95	41	:	:	PUNCT
admet-796	95	42	10	10	NUM
admet-796	95	43	ml	ml	NOUN
admet-796	95	44	/	/	SYM
admet-796	95	45	kg	kg	NOUN
admet-796	95	46	)	)	PUNCT
admet-796	95	47	,	,	PUNCT
admet-796	95	48	whereas	whereas	SCONJ
admet-796	95	49	group	group	NOUN
admet-796	95	50	ii	ii	PROPN
admet-796	95	51	animals	animal	NOUN
admet-796	95	52	(	(	PUNCT
admet-796	95	53	215	215	NUM
admet-796	95	54	-	-	SYM
admet-796	95	55	225	225	NUM
admet-796	95	56	g	g	NOUN
admet-796	95	57	)	)	PUNCT
admet-796	95	58	received	receive	VERB
admet-796	95	59	filgotinib	filgotinib	NOUN
admet-796	95	60	intravenously	intravenously	ADV
admet-796	95	61	(	(	PUNCT
admet-796	95	62	5	5	NUM
admet-796	95	63	%	%	NOUN
admet-796	95	64	dmso	dmso	NOUN
admet-796	95	65	,	,	PUNCT
admet-796	95	66	5	5	NUM
admet-796	95	67	%	%	NOUN
admet-796	95	68	solutol	solutol	NOUN
admet-796	95	69	:	:	PUNCT
admet-796	95	70	absolute	absolute	ADJ
admet-796	95	71	alcohol	alcohol	NOUN
admet-796	95	72	(	(	PUNCT
admet-796	95	73	1:1	1:1	NUM
admet-796	95	74	,	,	PUNCT
admet-796	95	75	v	v	NOUN
admet-796	95	76	/	/	SYM
admet-796	95	77	v	v	NOUN
admet-796	95	78	)	)	PUNCT
admet-796	95	79	and	and	CCONJ
admet-796	95	80	90	90	NUM
admet-796	95	81	%	%	NOUN
admet-796	95	82	of	of	ADP
admet-796	95	83	normal	normal	ADJ
admet-796	95	84	saline	saline	NOUN
admet-796	95	85	;	;	PUNCT
admet-796	95	86	strength	strength	NOUN
admet-796	95	87	:	:	PUNCT
admet-796	95	88	0.5	0.5	NUM
admet-796	95	89	mg	mg	NUM
admet-796	95	90	/	/	SYM
admet-796	95	91	ml	ml	PROPN
admet-796	95	92	;	;	PUNCT
admet-796	95	93	dose	dose	NOUN
admet-796	95	94	volume	volume	NOUN
admet-796	95	95	:	:	PUNCT
admet-796	95	96	4	4	NUM
admet-796	95	97	ml	ml	NOUN
admet-796	95	98	/	/	SYM
admet-796	95	99	kg	kg	NOUN
admet-796	95	100	)	)	PUNCT
admet-796	95	101	at	at	ADP
admet-796	95	102	2.0	2.0	NUM
admet-796	95	103	mg	mg	PROPN
admet-796	95	104	/	/	SYM
admet-796	95	105	kg	kg	PROPN
admet-796	95	106	dose	dose	PROPN
admet-796	95	107	.	.	PUNCT
admet-796	96	1	post	post	ADJ
admet-796	96	2	-	-	ADJ
admet-796	96	3	dosing	dosing	ADJ
admet-796	96	4	serial	serial	ADJ
admet-796	96	5	blood	blood	NOUN
admet-796	96	6	samples	sample	NOUN
admet-796	96	7	(	(	PUNCT
admet-796	96	8	50	50	NUM
admet-796	96	9	µl	µl	NOUN
admet-796	96	10	)	)	PUNCT
admet-796	96	11	were	be	AUX
admet-796	96	12	collected	collect	VERB
admet-796	96	13	through	through	ADP
admet-796	96	14	retro	retro	ADJ
admet-796	96	15	-	-	PUNCT
admet-796	96	16	orbital	orbital	ADJ
admet-796	96	17	plexus	plexus	NOUN
admet-796	96	18	into	into	ADP
admet-796	96	19	polypropylene	polypropylene	NOUN
admet-796	96	20	tubes	tube	NOUN
admet-796	96	21	containing	contain	VERB
admet-796	96	22	k2.edta	k2.edta	NOUN
admet-796	96	23	solution	solution	NOUN
admet-796	96	24	as	as	ADP
admet-796	96	25	an	an	DET
admet-796	96	26	anti	anti	ADJ
admet-796	96	27	-	-	NOUN
admet-796	96	28	coagulant	coagulant	NOUN
admet-796	96	29	at	at	ADP
admet-796	96	30	0.25	0.25	NUM
admet-796	96	31	,	,	PUNCT
admet-796	96	32	0.5	0.5	NUM
admet-796	96	33	,	,	PUNCT
admet-796	96	34	1	1	NUM
admet-796	96	35	,	,	PUNCT
admet-796	96	36	2	2	NUM
admet-796	96	37	,	,	PUNCT
admet-796	96	38	4	4	NUM
admet-796	96	39	,	,	PUNCT
admet-796	96	40	8	8	NUM
admet-796	96	41	,	,	PUNCT
admet-796	96	42	10	10	NUM
admet-796	96	43	,	,	PUNCT
admet-796	96	44	12	12	NUM
admet-796	96	45	and	and	CCONJ
admet-796	96	46	24	24	NUM
admet-796	96	47	h	h	NOUN
admet-796	96	48	(	(	PUNCT
admet-796	96	49	for	for	ADP
admet-796	96	50	oral	oral	ADJ
admet-796	96	51	study	study	NOUN
admet-796	96	52	)	)	PUNCT
admet-796	96	53	and	and	CCONJ
admet-796	96	54	0.083	0.083	NUM
admet-796	96	55	,	,	PUNCT
admet-796	96	56	0.25	0.25	NUM
admet-796	96	57	,	,	PUNCT
admet-796	96	58	0.5	0.5	NUM
admet-796	96	59	,	,	PUNCT
admet-796	96	60	1	1	NUM
admet-796	96	61	,	,	PUNCT
admet-796	96	62	2	2	NUM
admet-796	96	63	,	,	PUNCT
admet-796	96	64	4	4	NUM
admet-796	96	65	,	,	PUNCT
admet-796	96	66	8	8	NUM
admet-796	96	67	and	and	CCONJ
admet-796	96	68	24	24	NUM
admet-796	96	69	h	h	NOUN
admet-796	96	70	(	(	PUNCT
admet-796	96	71	for	for	ADP
admet-796	96	72	intravenous	intravenous	ADJ
admet-796	96	73	study	study	NOUN
admet-796	96	74	)	)	PUNCT
admet-796	96	75	.	.	PUNCT
admet-796	97	1	animals	animal	NOUN
admet-796	97	2	were	be	AUX
admet-796	97	3	allowed	allow	VERB
admet-796	97	4	to	to	PART
admet-796	97	5	access	access	VERB
admet-796	97	6	feed	feed	NOUN
admet-796	97	7	2	2	NUM
admet-796	97	8	h	h	NOUN
admet-796	97	9	post	post	ADJ
admet-796	97	10	-	-	ADJ
admet-796	97	11	dosing	dosing	ADJ
admet-796	97	12	.	.	PUNCT
admet-796	98	1	pharmacokinetic	pharmacokinetic	ADJ
admet-796	98	2	analysis	analysis	NOUN
admet-796	98	3	blood	blood	NOUN
admet-796	98	4	concentration	concentration	NOUN
admet-796	98	5	-	-	PUNCT
admet-796	98	6	time	time	NOUN
admet-796	98	7	data	datum	NOUN
admet-796	98	8	of	of	ADP
admet-796	98	9	filgotinib	filgotinib	NOUN
admet-796	98	10	was	be	AUX
admet-796	98	11	analyzed	analyze	VERB
admet-796	98	12	by	by	ADP
admet-796	98	13	non	non	ADJ
admet-796	98	14	-	-	ADJ
admet-796	98	15	compartmental	compartmental	ADJ
admet-796	98	16	method	method	NOUN
admet-796	98	17	and	and	CCONJ
admet-796	98	18	the	the	DET
admet-796	98	19	admet	admet	PROPN
admet-796	98	20	&	&	CCONJ
admet-796	98	21	dmpk	dmpk	PROPN
admet-796	98	22	8(2	8(2	NUM
admet-796	98	23	)	)	PUNCT
admet-796	98	24	(	(	PUNCT
admet-796	98	25	2020	2020	NUM
admet-796	98	26	)	)	PUNCT
admet-796	98	27	139	139	NUM
admet-796	98	28	-	-	SYM
admet-796	98	29	148	148	NUM
admet-796	98	30	dbs	dbs	NOUN
admet-796	98	31	method	method	NOUN
admet-796	98	32	for	for	ADP
admet-796	98	33	filgotinib	filgotinib	ADJ
admet-796	98	34	quantitation	quantitation	NOUN
admet-796	98	35	doi	doi	NOUN
admet-796	98	36	:	:	PUNCT
admet-796	98	37	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	X
admet-796	98	38	143	143	PRON
admet-796	98	39	relevant	relevant	ADJ
admet-796	98	40	pharmacokinetic	pharmacokinetic	ADJ
admet-796	98	41	parameters	parameter	NOUN
admet-796	98	42	namely	namely	ADV
admet-796	98	43	auc0-	auc0-	NOUN
admet-796	98	44	(	(	PUNCT
admet-796	98	45	area	area	NOUN
admet-796	98	46	under	under	ADP
admet-796	98	47	the	the	DET
admet-796	98	48	blood	blood	NOUN
admet-796	98	49	concentration	concentration	NOUN
admet-796	98	50	-	-	PUNCT
admet-796	98	51	time	time	NOUN
admet-796	98	52	curve	curve	NOUN
admet-796	98	53	from	from	ADP
admet-796	98	54	time	time	NOUN
admet-796	98	55	zero	zero	NUM
admet-796	98	56	to	to	ADP
admet-796	98	57	infinite	infinite	ADJ
admet-796	98	58	time	time	NOUN
admet-796	98	59	)	)	PUNCT
admet-796	98	60	,	,	PUNCT
admet-796	98	61	c0	c0	PROPN
admet-796	98	62	(	(	PUNCT
admet-796	98	63	extrapolated	extrapolate	VERB
admet-796	98	64	blood	blood	NOUN
admet-796	98	65	concentration	concentration	NOUN
admet-796	98	66	at	at	ADP
admet-796	98	67	time	time	NOUN
admet-796	98	68	zero	zero	NUM
admet-796	98	69	)	)	PUNCT
admet-796	98	70	,	,	PUNCT
admet-796	98	71	cmax	cmax	NOUN
admet-796	98	72	(	(	PUNCT
admet-796	98	73	maximum	maximum	ADJ
admet-796	98	74	blood	blood	NOUN
admet-796	98	75	concentration	concentration	NOUN
admet-796	98	76	)	)	PUNCT
admet-796	98	77	,	,	PUNCT
admet-796	98	78	tmax	tmax	X
admet-796	98	79	(	(	PUNCT
admet-796	98	80	time	time	NOUN
admet-796	98	81	to	to	PART
admet-796	98	82	reach	reach	VERB
admet-796	98	83	cmax	cmax	NOUN
admet-796	98	84	)	)	PUNCT
admet-796	98	85	,	,	PUNCT
admet-796	98	86	vd	vd	NOUN
admet-796	98	87	(	(	PUNCT
admet-796	98	88	volume	volume	NOUN
admet-796	98	89	of	of	ADP
admet-796	98	90	distribution	distribution	NOUN
admet-796	98	91	)	)	PUNCT
admet-796	98	92	,	,	PUNCT
admet-796	98	93	cl	cl	INTJ
admet-796	98	94	(	(	PUNCT
admet-796	98	95	clearance	clearance	NOUN
admet-796	98	96	)	)	PUNCT
admet-796	98	97	and	and	CCONJ
admet-796	98	98	t½	t½	PROPN
admet-796	98	99	(	(	PUNCT
admet-796	98	100	terminal	terminal	ADJ
admet-796	98	101	halflife	halflife	NOUN
admet-796	98	102	)	)	PUNCT
admet-796	98	103	were	be	AUX
admet-796	98	104	calculated	calculate	VERB
admet-796	98	105	using	use	VERB
admet-796	98	106	phoenix	phoenix	PROPN
admet-796	98	107	winnonlin	winnonlin	PROPN
admet-796	98	108	software	software	NOUN
admet-796	98	109	(	(	PUNCT
admet-796	98	110	version	version	NOUN
admet-796	98	111	8.1	8.1	NUM
admet-796	98	112	;	;	PUNCT
admet-796	98	113	pharsight	pharsight	NOUN
admet-796	98	114	corporation	corporation	NOUN
admet-796	98	115	,	,	PUNCT
admet-796	98	116	mountain	mountain	NOUN
admet-796	98	117	view	view	NOUN
admet-796	98	118	,	,	PUNCT
admet-796	98	119	ca	ca	NOUN
admet-796	98	120	)	)	PUNCT
admet-796	98	121	.	.	PUNCT
admet-796	99	1	absolute	absolute	ADJ
admet-796	99	2	oral	oral	ADJ
admet-796	99	3	bioavailability	bioavailability	NOUN
admet-796	99	4	(	(	PUNCT
admet-796	99	5	f	f	X
admet-796	99	6	)	)	PUNCT
admet-796	99	7	was	be	AUX
admet-796	99	8	calculated	calculate	VERB
admet-796	99	9	using	use	VERB
admet-796	99	10	this	this	DET
admet-796	99	11	formula	formula	NOUN
admet-796	99	12	[	[	X
admet-796	99	13	dose	dose	X
admet-796	99	14	(	(	PUNCT
admet-796	99	15	i.v	i.v	PROPN
admet-796	99	16	.	.	PUNCT
admet-796	99	17	)	)	PUNCT
admet-796	100	1	×	×	NOUN
admet-796	100	2	auc(0-)oral	auc(0-)oral	ADV
admet-796	100	3	/	/	SYM
admet-796	100	4	dose	dose	NOUN
admet-796	100	5	(	(	PUNCT
admet-796	100	6	oral	oral	ADJ
admet-796	100	7	)	)	PUNCT
admet-796	100	8	×	×	PROPN
admet-796	100	9	auc(0-)i.v	auc(0-)i.v	NOUN
admet-796	100	10	.	.	PUNCT
admet-796	100	11	]	]	PUNCT
admet-796	101	1	×	×	PROPN
admet-796	101	2	100	100	NUM
admet-796	101	3	.	.	PUNCT
admet-796	102	1	results	result	NOUN
admet-796	102	2	and	and	CCONJ
admet-796	102	3	discussion	discussion	NOUN
admet-796	102	4	method	method	NOUN
admet-796	102	5	development	development	NOUN
admet-796	102	6	the	the	DET
admet-796	102	7	objective	objective	NOUN
admet-796	102	8	of	of	ADP
admet-796	102	9	this	this	DET
admet-796	102	10	work	work	NOUN
admet-796	102	11	was	be	AUX
admet-796	102	12	to	to	PART
admet-796	102	13	develop	develop	VERB
admet-796	102	14	a	a	DET
admet-796	102	15	sensitive	sensitive	ADJ
admet-796	102	16	and	and	CCONJ
admet-796	102	17	rugged	rugged	ADJ
admet-796	102	18	dbs	dbs	NOUN
admet-796	102	19	method	method	NOUN
admet-796	102	20	for	for	ADP
admet-796	102	21	the	the	DET
admet-796	102	22	quantification	quantification	NOUN
admet-796	102	23	of	of	ADP
admet-796	102	24	filgotinib	filgotinib	NOUN
admet-796	102	25	in	in	ADP
admet-796	102	26	rat	rat	NOUN
admet-796	102	27	blood	blood	NOUN
admet-796	102	28	and	and	CCONJ
admet-796	102	29	subsequently	subsequently	ADV
admet-796	102	30	show	show	VERB
admet-796	102	31	the	the	DET
admet-796	102	32	correlation	correlation	NOUN
admet-796	102	33	with	with	ADP
admet-796	102	34	previously	previously	ADV
admet-796	102	35	developed	develop	VERB
admet-796	102	36	method	method	NOUN
admet-796	102	37	[	[	X
admet-796	102	38	10	10	NUM
admet-796	102	39	]	]	PUNCT
admet-796	102	40	in	in	ADP
admet-796	102	41	a	a	DET
admet-796	102	42	pharmacokinetics	pharmacokinetic	NOUN
admet-796	102	43	study	study	NOUN
admet-796	102	44	so	so	SCONJ
admet-796	102	45	that	that	SCONJ
admet-796	102	46	dbs	dbs	NOUN
admet-796	102	47	method	method	NOUN
admet-796	102	48	can	can	AUX
admet-796	102	49	be	be	AUX
admet-796	102	50	used	use	VERB
admet-796	102	51	as	as	ADP
admet-796	102	52	an	an	DET
admet-796	102	53	alternative	alternative	ADJ
admet-796	102	54	method	method	NOUN
admet-796	102	55	to	to	PART
admet-796	102	56	measure	measure	VERB
admet-796	102	57	the	the	DET
admet-796	102	58	filgotinib	filgotinib	ADJ
admet-796	102	59	concentrations	concentration	NOUN
admet-796	102	60	.	.	PUNCT
admet-796	103	1	previously	previously	ADV
admet-796	103	2	reported	report	VERB
admet-796	103	3	lc	lc	PROPN
admet-796	103	4	-	-	PUNCT
admet-796	103	5	ms	ms	PROPN
admet-796	103	6	/	/	SYM
admet-796	103	7	ms	ms	NOUN
admet-796	103	8	conditions	condition	NOUN
admet-796	103	9	were	be	AUX
admet-796	103	10	utilized	utilize	VERB
admet-796	103	11	for	for	ADP
admet-796	103	12	this	this	DET
admet-796	103	13	method	method	NOUN
admet-796	103	14	[	[	X
admet-796	103	15	10	10	NUM
admet-796	103	16	]	]	PUNCT
admet-796	103	17	.	.	PUNCT
admet-796	104	1	since	since	SCONJ
admet-796	104	2	chromatography	chromatography	NOUN
admet-796	104	3	and	and	CCONJ
admet-796	104	4	mass	mass	NOUN
admet-796	104	5	spectrometric	spectrometric	ADJ
admet-796	104	6	conditions	condition	NOUN
admet-796	104	7	were	be	AUX
admet-796	104	8	optimized	optimize	VERB
admet-796	104	9	,	,	PUNCT
admet-796	104	10	to	to	PART
admet-796	104	11	obtain	obtain	VERB
admet-796	104	12	better	well	ADJ
admet-796	104	13	sensitivity	sensitivity	NOUN
admet-796	104	14	extraction	extraction	NOUN
admet-796	104	15	optimization	optimization	NOUN
admet-796	104	16	was	be	AUX
admet-796	104	17	done	do	VERB
admet-796	104	18	with	with	ADP
admet-796	104	19	various	various	ADJ
admet-796	104	20	extraction	extraction	NOUN
admet-796	104	21	solvents	solvent	NOUN
admet-796	104	22	namely	namely	ADV
admet-796	104	23	acetonitrile	acetonitrile	NOUN
admet-796	104	24	,	,	PUNCT
admet-796	104	25	methanol	methanol	NOUN
admet-796	104	26	,	,	PUNCT
admet-796	104	27	ethyl	ethyl	PROPN
admet-796	104	28	acetate	acetate	NOUN
admet-796	104	29	,	,	PUNCT
admet-796	104	30	acidified	acidify	VERB
admet-796	104	31	methanol	methanol	NOUN
admet-796	104	32	/	/	SYM
admet-796	104	33	acetonitrile	acetonitrile	NOUN
admet-796	104	34	,	,	PUNCT
admet-796	104	35	mixture	mixture	NOUN
admet-796	104	36	of	of	ADP
admet-796	104	37	water	water	NOUN
admet-796	104	38	and	and	CCONJ
admet-796	104	39	methanol	methanol	NOUN
admet-796	104	40	/	/	SYM
admet-796	104	41	acetonitrile	acetonitrile	NOUN
admet-796	104	42	,	,	PUNCT
admet-796	104	43	pre	pre	ADJ
admet-796	104	44	-	-	NOUN
admet-796	104	45	treatment	treatment	NOUN
admet-796	104	46	of	of	ADP
admet-796	104	47	dbs	dbs	PROPN
admet-796	104	48	discs	disc	NOUN
admet-796	104	49	with	with	ADP
admet-796	104	50	formic	formic	ADJ
admet-796	104	51	acid	acid	NOUN
admet-796	104	52	followed	follow	VERB
admet-796	104	53	by	by	ADP
admet-796	104	54	extraction	extraction	NOUN
admet-796	104	55	with	with	ADP
admet-796	104	56	methanol	methanol	NOUN
admet-796	104	57	/	/	SYM
admet-796	104	58	acetonitrile	acetonitrile	NOUN
admet-796	104	59	/	/	SYM
admet-796	104	60	ethyl	ethyl	PROPN
admet-796	104	61	acetate	acetate	NOUN
admet-796	104	62	.	.	PUNCT
admet-796	105	1	method	method	NOUN
admet-796	105	2	validation	validation	NOUN
admet-796	105	3	parameters	parameter	NOUN
admet-796	105	4	recovery	recovery	VERB
admet-796	105	5	none	none	NOUN
admet-796	105	6	of	of	ADP
admet-796	105	7	the	the	DET
admet-796	105	8	single	single	ADJ
admet-796	105	9	organic	organic	ADJ
admet-796	105	10	solvents	solvent	NOUN
admet-796	105	11	and	and	CCONJ
admet-796	105	12	pure	pure	ADJ
admet-796	105	13	water	water	NOUN
admet-796	105	14	gave	give	VERB
admet-796	105	15	good	good	ADJ
admet-796	105	16	recovery	recovery	NOUN
admet-796	105	17	of	of	ADP
admet-796	105	18	filgotinib	filgotinib	NOUN
admet-796	105	19	from	from	ADP
admet-796	105	20	the	the	DET
admet-796	105	21	dbs	dbs	PROPN
admet-796	105	22	discs	disc	NOUN
admet-796	105	23	.	.	PUNCT
admet-796	106	1	the	the	DET
admet-796	106	2	recovery	recovery	NOUN
admet-796	106	3	with	with	ADP
admet-796	106	4	ethyl	ethyl	PROPN
admet-796	106	5	acetate	acetate	NOUN
admet-796	106	6	,	,	PUNCT
admet-796	106	7	water	water	NOUN
admet-796	106	8	and	and	CCONJ
admet-796	106	9	methanol	methanol	NOUN
admet-796	106	10	/	/	SYM
admet-796	106	11	acetonitrile	acetonitrile	NOUN
admet-796	106	12	was	be	AUX
admet-796	106	13	5	5	NUM
admet-796	106	14	,	,	PUNCT
admet-796	106	15	39	39	NUM
admet-796	106	16	and	and	CCONJ
admet-796	106	17	43	43	NUM
admet-796	106	18	%	%	NOUN
admet-796	106	19	,	,	PUNCT
admet-796	106	20	respectively	respectively	ADV
admet-796	106	21	.	.	PUNCT
admet-796	107	1	with	with	ADP
admet-796	107	2	methanol	methanol	NOUN
admet-796	107	3	/	/	SYM
admet-796	107	4	acetonitrile	acetonitrile	NOUN
admet-796	107	5	:	:	PUNCT
admet-796	107	6	water	water	NOUN
admet-796	107	7	50:50	50:50	NUM
admet-796	107	8	and	and	CCONJ
admet-796	107	9	20:80	20:80	NUM
admet-796	107	10	,	,	PUNCT
admet-796	107	11	the	the	DET
admet-796	107	12	recovery	recovery	NOUN
admet-796	107	13	was	be	AUX
admet-796	107	14	found	find	VERB
admet-796	107	15	to	to	PART
admet-796	107	16	be	be	AUX
admet-796	107	17	30	30	NUM
admet-796	107	18	and	and	CCONJ
admet-796	107	19	43	43	NUM
admet-796	107	20	%	%	NOUN
admet-796	107	21	,	,	PUNCT
admet-796	107	22	respectively	respectively	ADV
admet-796	107	23	.	.	PUNCT
admet-796	108	1	in	in	ADP
admet-796	108	2	order	order	NOUN
admet-796	108	3	to	to	PART
admet-796	108	4	improve	improve	VERB
admet-796	108	5	the	the	DET
admet-796	108	6	recovery	recovery	NOUN
admet-796	108	7	,	,	PUNCT
admet-796	108	8	the	the	DET
admet-796	108	9	dbs	dbs	PROPN
admet-796	108	10	discs	disc	NOUN
admet-796	108	11	were	be	AUX
admet-796	108	12	pre	pre	VERB
admet-796	108	13	-	-	VERB
admet-796	108	14	treated	treat	VERB
admet-796	108	15	with	with	ADP
admet-796	108	16	0.2	0.2	NUM
admet-796	108	17	%	%	NOUN
admet-796	108	18	formic	formic	PROPN
admet-796	108	19	acid	acid	NOUN
admet-796	108	20	and	and	CCONJ
admet-796	108	21	extracted	extract	VERB
admet-796	108	22	with	with	ADP
admet-796	108	23	ethyl	ethyl	PROPN
admet-796	108	24	acetate	acetate	NOUN
admet-796	108	25	.	.	PUNCT
admet-796	109	1	this	this	DET
admet-796	109	2	process	process	NOUN
admet-796	109	3	helped	help	VERB
admet-796	109	4	to	to	PART
admet-796	109	5	attain	attain	VERB
admet-796	109	6	the	the	DET
admet-796	109	7	recovery	recovery	NOUN
admet-796	109	8	up	up	ADP
admet-796	109	9	to	to	PART
admet-796	109	10	62	62	NUM
admet-796	109	11	%	%	NOUN
admet-796	109	12	.	.	PUNCT
admet-796	110	1	the	the	DET
admet-796	110	2	mean	mean	ADJ
admet-796	110	3	±	±	PROPN
admet-796	110	4	s.d	s.d	PROPN
admet-796	110	5	recovery	recovery	NOUN
admet-796	110	6	of	of	ADP
admet-796	110	7	filgotinib	filgotinib	NOUN
admet-796	110	8	at	at	ADP
admet-796	110	9	lqc	lqc	NOUN
admet-796	110	10	and	and	CCONJ
admet-796	110	11	hqc	hqc	PROPN
admet-796	110	12	was	be	AUX
admet-796	110	13	found	find	VERB
admet-796	110	14	to	to	PART
admet-796	110	15	be	be	AUX
admet-796	110	16	62.4	62.4	NUM
admet-796	110	17	±	±	NUM
admet-796	110	18	8.39	8.39	NUM
admet-796	110	19	and	and	CCONJ
admet-796	110	20	64.2	64.2	NUM
admet-796	110	21	±	±	NUM
admet-796	110	22	4.26	4.26	NUM
admet-796	110	23	%	%	NOUN
admet-796	110	24	,	,	PUNCT
admet-796	110	25	respectively	respectively	ADV
admet-796	110	26	.	.	PUNCT
admet-796	111	1	the	the	DET
admet-796	111	2	recovery	recovery	NOUN
admet-796	111	3	of	of	ADP
admet-796	111	4	the	the	PRON
admet-796	111	5	is	be	AUX
admet-796	111	6	was	be	AUX
admet-796	111	7	95.2	95.2	NUM
admet-796	111	8	±	±	NUM
admet-796	111	9	4.85	4.85	NUM
admet-796	111	10	%	%	NOUN
admet-796	111	11	.	.	PUNCT
admet-796	112	1	matrix	matrix	NOUN
admet-796	112	2	effect	effect	NOUN
admet-796	112	3	the	the	DET
admet-796	112	4	mean	mean	ADJ
admet-796	112	5	absolute	absolute	ADJ
admet-796	112	6	matrix	matrix	NOUN
admet-796	112	7	effect	effect	NOUN
admet-796	112	8	for	for	ADP
admet-796	112	9	filgotinib	filgotinib	NOUN
admet-796	112	10	on	on	ADP
admet-796	112	11	rat	rat	NOUN
admet-796	112	12	dbs	dbs	PROPN
admet-796	112	13	cards	card	NOUN
admet-796	112	14	at	at	ADP
admet-796	112	15	lqc	lqc	ADV
admet-796	112	16	and	and	CCONJ
admet-796	112	17	hqc	hqc	PROPN
admet-796	112	18	was	be	AUX
admet-796	112	19	found	find	VERB
admet-796	112	20	to	to	PART
admet-796	112	21	be	be	AUX
admet-796	112	22	0.81	0.81	NUM
admet-796	112	23	±	±	NUM
admet-796	112	24	0.08	0.08	NUM
admet-796	112	25	and	and	CCONJ
admet-796	112	26	0.83	0.83	NUM
admet-796	112	27	±	±	NUM
admet-796	112	28	0.08	0.08	NUM
admet-796	112	29	%	%	NOUN
admet-796	112	30	,	,	PUNCT
admet-796	112	31	respectively	respectively	ADV
admet-796	112	32	.	.	PUNCT
admet-796	113	1	the	the	DET
admet-796	113	2	matrix	matrix	NOUN
admet-796	113	3	effect	effect	NOUN
admet-796	113	4	for	for	ADP
admet-796	113	5	the	the	PRON
admet-796	113	6	is	be	AUX
admet-796	113	7	was	be	AUX
admet-796	113	8	0.97	0.97	NUM
admet-796	113	9	±	±	NUM
admet-796	113	10	0.05	0.05	NUM
admet-796	113	11	%	%	NOUN
admet-796	113	12	(	(	PUNCT
admet-796	113	13	at	at	ADP
admet-796	113	14	100	100	NUM
admet-796	113	15	ng	ng	NOUN
admet-796	113	16	/	/	SYM
admet-796	113	17	ml	ml	NOUN
admet-796	113	18	)	)	PUNCT
admet-796	113	19	.	.	PUNCT
admet-796	114	1	these	these	DET
admet-796	114	2	results	result	NOUN
admet-796	114	3	indicate	indicate	VERB
admet-796	114	4	that	that	SCONJ
admet-796	114	5	the	the	DET
admet-796	114	6	minimal	minimal	ADJ
admet-796	114	7	matrix	matrix	NOUN
admet-796	114	8	effect	effect	NOUN
admet-796	114	9	did	do	AUX
admet-796	114	10	not	not	PART
admet-796	114	11	obscure	obscure	VERB
admet-796	114	12	the	the	DET
admet-796	114	13	quantification	quantification	NOUN
admet-796	114	14	of	of	ADP
admet-796	114	15	on	on	ADP
admet-796	114	16	filgotinib	filgotinib	NOUN
admet-796	114	17	and	and	CCONJ
admet-796	114	18	the	the	PRON
admet-796	114	19	is	be	AUX
admet-796	114	20	from	from	ADP
admet-796	114	21	rat	rat	NOUN
admet-796	114	22	dbs	dbs	NOUN
admet-796	114	23	cards	card	NOUN
admet-796	114	24	.	.	PUNCT
admet-796	115	1	selectivity	selectivity	NOUN
admet-796	115	2	and	and	CCONJ
admet-796	115	3	carry	carry	VERB
admet-796	115	4	over	over	ADP
admet-796	115	5	figures	figure	NOUN
admet-796	115	6	2a	2a	NUM
admet-796	115	7	,	,	PUNCT
admet-796	115	8	b	b	X
admet-796	115	9	,	,	PUNCT
admet-796	115	10	c	c	PROPN
admet-796	115	11	show	show	VERB
admet-796	115	12	chromatograms	chromatogram	NOUN
admet-796	115	13	for	for	ADP
admet-796	115	14	the	the	DET
admet-796	115	15	blank	blank	ADJ
admet-796	115	16	rat	rat	NOUN
admet-796	115	17	dbs	dbs	NOUN
admet-796	115	18	cards	card	NOUN
admet-796	115	19	(	(	PUNCT
admet-796	115	20	free	free	ADJ
admet-796	115	21	of	of	ADP
admet-796	115	22	analyte	analyte	NOUN
admet-796	115	23	and	and	CCONJ
admet-796	115	24	the	the	PRON
admet-796	115	25	is	be	AUX
admet-796	115	26	;	;	PUNCT
admet-796	115	27	figure	figure	NOUN
admet-796	115	28	2a	2a	NUM
admet-796	115	29	)	)	PUNCT
admet-796	115	30	,	,	PUNCT
admet-796	115	31	blank	blank	ADJ
admet-796	115	32	rat	rat	NOUN
admet-796	115	33	dbs	dbs	PROPN
admet-796	115	34	cards	card	NOUN
admet-796	115	35	spiked	spike	VERB
admet-796	115	36	with	with	ADP
admet-796	115	37	filgotinib	filgotinib	NOUN
admet-796	115	38	at	at	ADP
admet-796	115	39	lloq	lloq	NOUN
admet-796	115	40	and	and	CCONJ
admet-796	115	41	the	the	PRON
admet-796	115	42	is	be	AUX
admet-796	115	43	(	(	PUNCT
admet-796	115	44	figure	figure	NOUN
admet-796	115	45	2b	2b	NOUN
admet-796	115	46	)	)	PUNCT
admet-796	115	47	and	and	CCONJ
admet-796	115	48	an	an	DET
admet-796	115	49	in	in	ADP
admet-796	115	50	vivo	vivo	ADJ
admet-796	115	51	blood	blood	NOUN
admet-796	115	52	sample	sample	NOUN
admet-796	115	53	obtained	obtain	VERB
admet-796	115	54	at	at	ADP
admet-796	115	55	0.25	0.25	NUM
admet-796	115	56	h	h	NOUN
admet-796	115	57	after	after	ADP
admet-796	115	58	oral	oral	ADJ
admet-796	115	59	administration	administration	NOUN
admet-796	115	60	of	of	ADP
admet-796	115	61	filgotinib	filgotinib	NOUN
admet-796	115	62	along	along	ADP
admet-796	115	63	with	with	ADP
admet-796	115	64	the	the	DET
admet-796	115	65	is	is	NOUN
admet-796	115	66	(	(	PUNCT
admet-796	115	67	figure	figure	NOUN
admet-796	115	68	2c	2c	NUM
admet-796	115	69	)	)	PUNCT
admet-796	115	70	.	.	PUNCT
admet-796	116	1	there	there	PRON
admet-796	116	2	was	be	VERB
admet-796	116	3	no	no	DET
admet-796	116	4	carryover	carryover	NOUN
admet-796	116	5	produced	produce	VERB
admet-796	116	6	by	by	ADP
admet-796	116	7	the	the	DET
admet-796	116	8	highest	high	ADJ
admet-796	116	9	calibration	calibration	NOUN
admet-796	116	10	sample	sample	NOUN
admet-796	116	11	on	on	ADP
admet-796	116	12	the	the	DET
admet-796	116	13	following	following	NOUN
admet-796	116	14	injected	inject	VERB
admet-796	116	15	blank	blank	ADJ
admet-796	116	16	dbs	dbs	PROPN
admet-796	116	17	extract	extract	NOUN
admet-796	116	18	sample	sample	NOUN
admet-796	116	19	.	.	PUNCT
admet-796	117	1	additionally	additionally	ADV
admet-796	117	2	,	,	PUNCT
admet-796	117	3	no	no	DET
admet-796	117	4	dbs	dbs	ADJ
admet-796	117	5	-	-	ADJ
admet-796	117	6	specific	specific	ADJ
admet-796	117	7	device	device	NOUN
admet-796	117	8	-	-	PUNCT
admet-796	117	9	oriented	orient	VERB
admet-796	117	10	carry	carry	NOUN
admet-796	117	11	-	-	PUNCT
admet-796	117	12	over	over	NOUN
admet-796	117	13	was	be	AUX
admet-796	117	14	noted	note	VERB
admet-796	117	15	.	.	PUNCT
admet-796	118	1	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PROPN
admet-796	118	2	r.	r.	PROPN
admet-796	118	3	mullangi	mullangi	PROPN
admet-796	118	4	et	et	PROPN
admet-796	118	5	al	al	PROPN
admet-796	118	6	.	.	PROPN
admet-796	118	7	admet	admet	PROPN
admet-796	118	8	&	&	CCONJ
admet-796	118	9	dmpk	dmpk	PROPN
admet-796	118	10	8(2	8(2	NUM
admet-796	118	11	)	)	PUNCT
admet-796	118	12	(	(	PUNCT
admet-796	118	13	2020	2020	NUM
admet-796	118	14	)	)	PUNCT
admet-796	119	1	139	139	NUM
admet-796	119	2	-	-	SYM
admet-796	119	3	148	148	NUM
admet-796	119	4	144	144	NUM
admet-796	119	5	a	a	DET
admet-796	119	6	)	)	PUNCT
admet-796	119	7	b	b	NOUN
admet-796	119	8	)	)	PUNCT
admet-796	119	9	c	c	NOUN
admet-796	119	10	)	)	PUNCT
admet-796	119	11	figure	figure	NOUN
admet-796	119	12	2	2	NUM
admet-796	119	13	.	.	PUNCT
admet-796	119	14	typical	typical	ADJ
admet-796	119	15	mrm	mrm	PROPN
admet-796	119	16	chromatograms	chromatogram	NOUN
admet-796	119	17	of	of	ADP
admet-796	119	18	filgotinib	filgotinib	NOUN
admet-796	119	19	(	(	PUNCT
admet-796	119	20	left	leave	VERB
admet-796	119	21	panel	panel	NOUN
admet-796	119	22	)	)	PUNCT
admet-796	119	23	and	and	CCONJ
admet-796	119	24	the	the	DET
admet-796	119	25	is	be	AUX
admet-796	119	26	(	(	PUNCT
admet-796	119	27	right	right	ADJ
admet-796	119	28	panel	panel	NOUN
admet-796	119	29	)	)	PUNCT
admet-796	119	30	in	in	ADP
admet-796	119	31	(	(	PUNCT
admet-796	119	32	a	a	X
admet-796	119	33	)	)	PUNCT
admet-796	119	34	rat	rat	NOUN
admet-796	119	35	blank	blank	ADJ
admet-796	119	36	dbs	dbs	PROPN
admet-796	119	37	card	card	NOUN
admet-796	119	38	(	(	PUNCT
admet-796	119	39	b	b	NOUN
admet-796	119	40	)	)	PUNCT
admet-796	119	41	rat	rat	NOUN
admet-796	119	42	blank	blank	ADJ
admet-796	119	43	dbs	dbs	PROPN
admet-796	119	44	card	card	NOUN
admet-796	119	45	spiked	spike	VERB
admet-796	119	46	with	with	ADP
admet-796	119	47	filgotinib	filgotinib	NOUN
admet-796	119	48	at	at	ADP
admet-796	119	49	lloq	lloq	PROPN
admet-796	119	50	(	(	PUNCT
admet-796	119	51	1.37	1.37	NUM
admet-796	119	52	ng	ng	PROPN
admet-796	119	53	/	/	SYM
admet-796	119	54	ml	ml	PROPN
admet-796	119	55	)	)	PUNCT
admet-796	119	56	and	and	CCONJ
admet-796	119	57	the	the	PRON
admet-796	119	58	is	be	AUX
admet-796	119	59	(	(	PUNCT
admet-796	119	60	c	c	NOUN
admet-796	119	61	)	)	PUNCT
admet-796	119	62	a	a	DET
admet-796	119	63	0.25	0.25	NUM
admet-796	119	64	h	h	NOUN
admet-796	119	65	in	in	ADP
admet-796	119	66	vivo	vivo	ADJ
admet-796	119	67	plasma	plasma	NOUN
admet-796	119	68	sample	sample	NOUN
admet-796	119	69	showing	show	VERB
admet-796	119	70	filgotinib	filgotinib	NOUN
admet-796	119	71	peak	peak	NOUN
admet-796	119	72	obtained	obtain	VERB
admet-796	119	73	following	follow	VERB
admet-796	119	74	oral	oral	ADJ
admet-796	119	75	administration	administration	NOUN
admet-796	119	76	to	to	PART
admet-796	119	77	rat	rat	VERB
admet-796	119	78	along	along	ADP
admet-796	119	79	with	with	ADP
admet-796	119	80	the	the	PRON
admet-796	119	81	is	be	AUX
admet-796	119	82	.	.	PUNCT
admet-796	120	1	d	d	NOUN
admet-796	120	2	if	if	SCONJ
admet-796	120	3	fe	fe	X
admet-796	120	4	r	r	NOUN
admet-796	120	5	e	e	NOUN
admet-796	120	6	n	n	ADP
admet-796	120	7	c	c	NOUN
admet-796	120	8	e	e	X
admet-796	120	9	(	(	PUNCT
admet-796	120	10	%	%	NOUN
admet-796	120	11	)	)	PUNCT
admet-796	120	12	1	1	NUM
admet-796	120	13	10	10	NUM
admet-796	120	14	100	100	NUM
admet-796	120	15	1000	1000	NUM
admet-796	120	16	10000	10000	NUM
admet-796	120	17	-20	-20	NUM
admet-796	120	18	-10	-10	SYM
admet-796	120	19	0	0	NUM
admet-796	120	20	10	10	NUM
admet-796	120	21	20	20	NUM
admet-796	120	22	mean	mean	NOUN
admet-796	120	23	value	value	NOUN
admet-796	120	24	(	(	PUNCT
admet-796	120	25	ng	ng	PROPN
admet-796	120	26	/	/	SYM
admet-796	120	27	ml)-log	ml)-log	PROPN
admet-796	120	28	scale	scale	NOUN
admet-796	120	29	figure	figure	NOUN
admet-796	120	30	3	3	NUM
admet-796	120	31	.	.	PUNCT
admet-796	120	32	bland	bland	ADJ
admet-796	120	33	-	-	PUNCT
admet-796	120	34	altman	altman	NOUN
admet-796	120	35	plot	plot	NOUN
admet-796	120	36	showing	show	VERB
admet-796	120	37	the	the	DET
admet-796	120	38	incurred	incur	VERB
admet-796	120	39	sample	sample	NOUN
admet-796	120	40	re	re	NOUN
admet-796	120	41	-	-	NOUN
admet-796	120	42	analysis	analysis	NOUN
admet-796	120	43	data	datum	NOUN
admet-796	120	44	for	for	ADP
admet-796	120	45	filgotinib	filgotinib	NOUN
admet-796	120	46	on	on	ADP
admet-796	120	47	dbs	dbs	PROPN
admet-796	120	48	.	.	PROPN
admet-796	120	49	calibration	calibration	NOUN
admet-796	120	50	curve	curve	VERB
admet-796	120	51	the	the	DET
admet-796	120	52	calibration	calibration	NOUN
admet-796	120	53	curve	curve	NOUN
admet-796	120	54	was	be	AUX
admet-796	120	55	constructed	construct	VERB
admet-796	120	56	in	in	ADP
admet-796	120	57	the	the	DET
admet-796	120	58	linear	linear	ADJ
admet-796	120	59	range	range	NOUN
admet-796	120	60	using	use	VERB
admet-796	120	61	eight	eight	NUM
admet-796	120	62	calibrators	calibrator	NOUN
admet-796	120	63	1.34	1.34	NUM
admet-796	120	64	,	,	PUNCT
admet-796	120	65	2.67	2.67	NUM
admet-796	120	66	,	,	PUNCT
admet-796	120	67	14.7	14.7	NUM
admet-796	120	68	,	,	PUNCT
admet-796	120	69	26.7	26.7	NUM
admet-796	120	70	,	,	PUNCT
admet-796	120	71	400	400	NUM
admet-796	120	72	,	,	PUNCT
admet-796	120	73	801	801	NUM
admet-796	120	74	,	,	PUNCT
admet-796	120	75	1603	1603	NUM
admet-796	120	76	and	and	CCONJ
admet-796	120	77	1937	1937	NUM
admet-796	120	78	ng	ng	PROPN
admet-796	120	79	/	/	SYM
admet-796	120	80	ml	ml	PROPN
admet-796	120	81	.	.	PUNCT
admet-796	121	1	the	the	DET
admet-796	121	2	typical	typical	ADJ
admet-796	121	3	regression	regression	NOUN
admet-796	121	4	equation	equation	NOUN
admet-796	121	5	for	for	ADP
admet-796	121	6	calibration	calibration	NOUN
admet-796	121	7	curve	curve	NOUN
admet-796	121	8	was	be	AUX
admet-796	122	1	y	y	PROPN
admet-796	122	2	=	=	PUNCT
admet-796	122	3	0.000849	0.000849	NUM
admet-796	122	4	x	x	PUNCT
admet-796	123	1	+	+	VERB
admet-796	123	2	0.00127	0.00127	NUM
admet-796	123	3	.	.	PUNCT
admet-796	124	1	the	the	DET
admet-796	124	2	correlation	correlation	NOUN
admet-796	124	3	coefficient	coefficient	NOUN
admet-796	124	4	(	(	PUNCT
admet-796	124	5	r	r	NOUN
admet-796	124	6	)	)	PUNCT
admet-796	124	7	average	average	ADJ
admet-796	124	8	regression	regression	NOUN
admet-796	124	9	(	(	PUNCT
admet-796	124	10	n=4	n=4	NOUN
admet-796	124	11	)	)	PUNCT
admet-796	124	12	was	be	AUX
admet-796	124	13	found	find	VERB
admet-796	124	14	to	to	PART
admet-796	124	15	be	be	AUX
admet-796	124	16	>	>	X
admet-796	124	17	0.9966	0.9966	NUM
admet-796	124	18	for	for	ADP
admet-796	124	19	filgotinib	filgotinib	NOUN
admet-796	124	20	.	.	PUNCT
admet-796	125	1	the	the	DET
admet-796	125	2	lowest	low	ADJ
admet-796	125	3	concentration	concentration	NOUN
admet-796	125	4	with	with	ADP
admet-796	125	5	the	the	DET
admet-796	125	6	rsd	rsd	NOUN
admet-796	125	7	<	<	NOUN
admet-796	125	8	20	20	NUM
admet-796	125	9	%	%	NOUN
admet-796	125	10	was	be	AUX
admet-796	125	11	taken	take	VERB
admet-796	125	12	as	as	ADP
admet-796	125	13	lloq	lloq	NOUN
admet-796	125	14	and	and	CCONJ
admet-796	125	15	was	be	AUX
admet-796	125	16	found	find	VERB
admet-796	125	17	to	to	PART
admet-796	125	18	be	be	AUX
admet-796	125	19	1.37	1.37	NUM
admet-796	125	20	ng	ng	PROPN
admet-796	125	21	/	/	SYM
admet-796	125	22	ml	ml	PROPN
admet-796	125	23	.	.	PUNCT
admet-796	126	1	the	the	DET
admet-796	126	2	accuracy	accuracy	NOUN
admet-796	126	3	observed	observe	VERB
admet-796	126	4	for	for	ADP
admet-796	126	5	the	the	DET
admet-796	126	6	mean	mean	NOUN
admet-796	126	7	of	of	ADP
admet-796	126	8	back	back	ADV
admet-796	126	9	-	-	PUNCT
admet-796	126	10	calculated	calculate	VERB
admet-796	126	11	concentrations	concentration	NOUN
admet-796	126	12	for	for	ADP
admet-796	126	13	four	four	NUM
admet-796	126	14	calibration	calibration	NOUN
admet-796	126	15	curves	curve	NOUN
admet-796	126	16	for	for	ADP
admet-796	126	17	filgotinib	filgotinib	NOUN
admet-796	126	18	was	be	AUX
admet-796	126	19	within	within	ADP
admet-796	126	20	95.9	95.9	NUM
admet-796	126	21	-	-	SYM
admet-796	126	22	110	110	NUM
admet-796	126	23	%	%	NOUN
admet-796	126	24	;	;	PUNCT
admet-796	126	25	while	while	SCONJ
admet-796	126	26	the	the	DET
admet-796	126	27	precision	precision	NOUN
admet-796	126	28	(	(	PUNCT
admet-796	126	29	cv	cv	NOUN
admet-796	126	30	)	)	PUNCT
admet-796	126	31	values	value	NOUN
admet-796	126	32	ranged	range	VERB
admet-796	126	33	from	from	ADP
admet-796	126	34	3.87	3.87	NUM
admet-796	126	35	-	-	SYM
admet-796	126	36	7.94	7.94	NUM
admet-796	126	37	%	%	NOUN
admet-796	126	38	.	.	PUNCT
admet-796	127	1	admet	admet	PROPN
admet-796	127	2	&	&	CCONJ
admet-796	127	3	dmpk	dmpk	PROPN
admet-796	127	4	8(2	8(2	NUM
admet-796	127	5	)	)	PUNCT
admet-796	127	6	(	(	PUNCT
admet-796	127	7	2020	2020	NUM
admet-796	127	8	)	)	PUNCT
admet-796	127	9	139	139	NUM
admet-796	127	10	-	-	SYM
admet-796	127	11	148	148	NUM
admet-796	127	12	dbs	dbs	NOUN
admet-796	127	13	method	method	NOUN
admet-796	127	14	for	for	ADP
admet-796	127	15	filgotinib	filgotinib	ADJ
admet-796	127	16	quantitation	quantitation	NOUN
admet-796	127	17	doi	doi	NOUN
admet-796	127	18	:	:	PUNCT
admet-796	127	19	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	NOUN
admet-796	127	20	145	145	NUM
admet-796	127	21	accuracy	accuracy	NOUN
admet-796	127	22	and	and	CCONJ
admet-796	127	23	precision	precision	NOUN
admet-796	127	24	accuracy	accuracy	NOUN
admet-796	127	25	and	and	CCONJ
admet-796	127	26	precision	precision	NOUN
admet-796	127	27	data	datum	NOUN
admet-796	127	28	for	for	ADP
admet-796	127	29	intraand	intraand	NOUN
admet-796	127	30	inter	inter	ADJ
admet-796	127	31	-	-	ADJ
admet-796	127	32	day	day	ADJ
admet-796	127	33	dbs	dbs	NOUN
admet-796	127	34	samples	sample	NOUN
admet-796	127	35	for	for	ADP
admet-796	127	36	filgotinib	filgotinib	NOUN
admet-796	127	37	is	be	AUX
admet-796	127	38	presented	present	VERB
admet-796	127	39	in	in	ADP
admet-796	127	40	table	table	NOUN
admet-796	127	41	1	1	NUM
admet-796	127	42	.	.	PUNCT
admet-796	128	1	the	the	DET
admet-796	128	2	assay	assay	ADJ
admet-796	128	3	values	value	NOUN
admet-796	128	4	on	on	ADP
admet-796	128	5	both	both	CCONJ
admet-796	128	6	the	the	DET
admet-796	128	7	occasions	occasion	NOUN
admet-796	128	8	(	(	PUNCT
admet-796	128	9	intraand	intraand	X
admet-796	128	10	inter	inter	NOUN
admet-796	128	11	-	-	NOUN
admet-796	128	12	day	day	NOUN
admet-796	128	13	)	)	PUNCT
admet-796	128	14	were	be	AUX
admet-796	128	15	found	find	VERB
admet-796	128	16	to	to	PART
admet-796	128	17	be	be	AUX
admet-796	128	18	within	within	ADP
admet-796	128	19	the	the	DET
admet-796	128	20	accepted	accepted	ADJ
admet-796	128	21	variable	variable	ADJ
admet-796	128	22	limits	limit	NOUN
admet-796	128	23	.	.	PUNCT
admet-796	129	1	stability	stability	NOUN
admet-796	129	2	the	the	DET
admet-796	129	3	predicted	predict	VERB
admet-796	129	4	concentrations	concentration	NOUN
admet-796	129	5	for	for	ADP
admet-796	129	6	filgotinib	filgotinib	NOUN
admet-796	129	7	at	at	ADP
admet-796	129	8	4.01	4.01	NUM
admet-796	129	9	and	and	CCONJ
admet-796	129	10	1736	1736	NUM
admet-796	129	11	ng	ng	NOUN
admet-796	129	12	/	/	SYM
admet-796	129	13	ml	ml	NOUN
admet-796	129	14	samples	sample	NOUN
admet-796	129	15	deviated	deviate	VERB
admet-796	129	16	within	within	ADP
admet-796	129	17	±15	±15	NOUN
admet-796	129	18	%	%	NOUN
admet-796	129	19	of	of	ADP
admet-796	129	20	the	the	DET
admet-796	129	21	fresh	fresh	ADJ
admet-796	129	22	sample	sample	NOUN
admet-796	129	23	concentrations	concentration	NOUN
admet-796	129	24	in	in	ADP
admet-796	129	25	a	a	DET
admet-796	129	26	battery	battery	NOUN
admet-796	129	27	of	of	ADP
admet-796	129	28	stability	stability	NOUN
admet-796	129	29	tests	test	NOUN
admet-796	129	30	:	:	PUNCT
admet-796	129	31	bench	bench	NOUN
admet-796	129	32	-	-	PUNCT
admet-796	129	33	top	top	NOUN
admet-796	129	34	(	(	PUNCT
admet-796	129	35	6	6	NUM
admet-796	129	36	h	h	NOUN
admet-796	129	37	)	)	PUNCT
admet-796	129	38	,	,	PUNCT
admet-796	129	39	in	in	ADP
admet-796	129	40	-	-	PUNCT
admet-796	129	41	injector	injector	NOUN
admet-796	129	42	(	(	PUNCT
admet-796	129	43	21	21	NUM
admet-796	129	44	h	h	NOUN
admet-796	129	45	)	)	PUNCT
admet-796	129	46	and	and	CCONJ
admet-796	129	47	freezer	freezer	NOUN
admet-796	129	48	stability	stability	NOUN
admet-796	129	49	at	at	ADP
admet-796	129	50	-80	-80	PUNCT
admet-796	129	51			PROPN
admet-796	129	52	10	10	NUM
admet-796	129	53	°	°	ADP
admet-796	129	54	c	c	NOUN
admet-796	129	55	for	for	ADP
admet-796	129	56	at	at	ADV
admet-796	129	57	least	least	ADJ
admet-796	129	58	for	for	ADP
admet-796	129	59	30	30	NUM
admet-796	129	60	days	day	NOUN
admet-796	129	61	(	(	PUNCT
admet-796	129	62	table	table	NOUN
admet-796	129	63	2	2	NUM
admet-796	129	64	)	)	PUNCT
admet-796	129	65	.	.	PUNCT
admet-796	130	1	the	the	DET
admet-796	130	2	results	result	NOUN
admet-796	130	3	were	be	AUX
admet-796	130	4	found	find	VERB
admet-796	130	5	to	to	PART
admet-796	130	6	be	be	AUX
admet-796	130	7	within	within	ADP
admet-796	130	8	the	the	DET
admet-796	130	9	assay	assay	NOUN
admet-796	130	10	variability	variability	NOUN
admet-796	130	11	limits	limit	NOUN
admet-796	130	12	during	during	ADP
admet-796	130	13	the	the	DET
admet-796	130	14	entire	entire	ADJ
admet-796	130	15	process	process	NOUN
admet-796	130	16	.	.	PUNCT
admet-796	131	1	table	table	NOUN
admet-796	131	2	1	1	NUM
admet-796	131	3	.	.	PUNCT
admet-796	131	4	precision	precision	NOUN
admet-796	131	5	and	and	CCONJ
admet-796	131	6	accuracy	accuracy	NOUN
admet-796	131	7	determination	determination	NOUN
admet-796	131	8	of	of	ADP
admet-796	131	9	filgotinib	filgotinib	ADJ
admet-796	131	10	quality	quality	NOUN
admet-796	131	11	controls	control	NOUN
admet-796	131	12	in	in	ADP
admet-796	131	13	rat	rat	NOUN
admet-796	131	14	plasma	plasma	NOUN
admet-796	131	15	lloq	lloq	PROPN
admet-796	131	16	qc	qc	PROPN
admet-796	131	17	(	(	PUNCT
admet-796	131	18	1.37	1.37	NUM
admet-796	131	19	ng	ng	PROPN
admet-796	131	20	/	/	SYM
admet-796	131	21	ml	ml	NOUN
admet-796	131	22	)	)	PUNCT
admet-796	131	23	lqc	lqc	NOUN
admet-796	131	24	(	(	PUNCT
admet-796	131	25	4.01	4.01	NUM
admet-796	131	26	ng	ng	NOUN
admet-796	131	27	/	/	SYM
admet-796	131	28	ml	ml	NOUN
admet-796	131	29	)	)	PUNCT
admet-796	131	30	mqc	mqc	NOUN
admet-796	131	31	(	(	PUNCT
admet-796	131	32	1068	1068	NUM
admet-796	131	33	ng	ng	NOUN
admet-796	131	34	/	/	SYM
admet-796	131	35	ml	ml	PROPN
admet-796	131	36	)	)	PUNCT
admet-796	131	37	hqc	hqc	NOUN
admet-796	131	38	(	(	PUNCT
admet-796	131	39	1736	1736	NUM
admet-796	131	40	ng	ng	NOUN
admet-796	131	41	/	/	SYM
admet-796	131	42	ml	ml	NOUN
admet-796	131	43	)	)	PUNCT
admet-796	131	44	intra	intra	ADJ
admet-796	131	45	-	-	NOUN
admet-796	131	46	day	day	NOUN
admet-796	131	47	(	(	PUNCT
admet-796	131	48	n=6	n=6	NOUN
admet-796	131	49	)	)	PUNCT
admet-796	131	50	mean	mean	VERB
admet-796	131	51	±	±	NUM
admet-796	131	52	s.d	s.d	VERB
admet-796	131	53	1.34	1.34	NUM
admet-796	131	54	±	±	NUM
admet-796	131	55	0.10	0.10	NUM
admet-796	131	56	4.30	4.30	NUM
admet-796	131	57	±	±	NUM
admet-796	131	58	0.45	0.45	NUM
admet-796	131	59	1136	1136	NUM
admet-796	131	60	±	±	NUM
admet-796	131	61	73.3	73.3	NUM
admet-796	131	62	1715	1715	NUM
admet-796	131	63	±	±	NUM
admet-796	131	64	124	124	NUM
admet-796	131	65	precision	precision	NOUN
admet-796	131	66	(	(	PUNCT
admet-796	131	67	%	%	INTJ
admet-796	131	68	rsd	rsd	NOUN
admet-796	131	69	)	)	PUNCT
admet-796	131	70	7.38	7.38	NUM
admet-796	131	71	10.4	10.4	NUM
admet-796	131	72	6.46	6.46	NUM
admet-796	131	73	7.23	7.23	NUM
admet-796	131	74	accuracy	accuracy	NOUN
admet-796	131	75	(	(	PUNCT
admet-796	131	76	%	%	INTJ
admet-796	131	77	re	re	NOUN
admet-796	131	78	)	)	PUNCT
admet-796	131	79	1.00	1.00	NUM
admet-796	131	80	1.07	1.07	NUM
admet-796	131	81	1.06	1.06	NUM
admet-796	131	82	0.99	0.99	NUM
admet-796	131	83	inter	inter	NOUN
admet-796	131	84	-	-	NOUN
admet-796	131	85	day	day	NOUN
admet-796	131	86	(	(	PUNCT
admet-796	131	87	n=24	n=24	PROPN
admet-796	131	88	)	)	PUNCT
admet-796	131	89	mean	mean	VERB
admet-796	132	1	±	±	NUM
admet-796	132	2	s.d	s.d	PROPN
admet-796	132	3	1.33	1.33	NUM
admet-796	132	4	±	±	NUM
admet-796	132	5	0.15	0.15	NUM
admet-796	132	6	3.94	3.94	NUM
admet-796	132	7	±	±	NUM
admet-796	132	8	0.44	0.44	NUM
admet-796	132	9	1064	1064	NUM
admet-796	132	10	±	±	NOUN
admet-796	132	11	96.8	96.8	NUM
admet-796	132	12	1663	1663	NUM
admet-796	132	13	±	±	NUM
admet-796	132	14	128	128	NUM
admet-796	132	15	precision	precision	NOUN
admet-796	132	16	(	(	PUNCT
admet-796	132	17	%	%	INTJ
admet-796	132	18	rsd	rsd	NOUN
admet-796	132	19	)	)	PUNCT
admet-796	132	20	11.0	11.0	NUM
admet-796	132	21	11.2	11.2	NUM
admet-796	132	22	9.09	9.09	NUM
admet-796	132	23	7.71	7.71	NUM
admet-796	132	24	accuracy	accuracy	NOUN
admet-796	132	25	(	(	PUNCT
admet-796	132	26	%	%	INTJ
admet-796	132	27	re	re	NOUN
admet-796	132	28	)	)	PUNCT
admet-796	132	29	1.00	1.00	NUM
admet-796	132	30	0.98	0.98	NUM
admet-796	132	31	1.00	1.00	NUM
admet-796	132	32	0.96	0.96	NUM
admet-796	132	33	rsd	rsd	NOUN
admet-796	132	34	:	:	PUNCT
admet-796	132	35	relative	relative	ADJ
admet-796	132	36	standard	standard	ADJ
admet-796	132	37	deviation	deviation	NOUN
admet-796	132	38	(	(	PUNCT
admet-796	132	39	sd	sd	NOUN
admet-796	132	40	100	100	ADV
admet-796	132	41	/	/	SYM
admet-796	132	42	mean	mean	NOUN
admet-796	132	43	)	)	PUNCT
admet-796	132	44	re	re	ADP
admet-796	132	45	:	:	PUNCT
admet-796	132	46	relative	relative	ADJ
admet-796	132	47	error	error	NOUN
admet-796	132	48	(	(	PUNCT
admet-796	132	49	measured	measure	VERB
admet-796	132	50	value	value	NOUN
admet-796	132	51	/	/	SYM
admet-796	132	52	actual	actual	ADJ
admet-796	132	53	value	value	NOUN
admet-796	132	54	)	)	PUNCT
admet-796	132	55	table	table	NOUN
admet-796	132	56	2	2	NUM
admet-796	132	57	.	.	PUNCT
admet-796	132	58	stability	stability	NOUN
admet-796	132	59	data	datum	NOUN
admet-796	132	60	of	of	ADP
admet-796	132	61	filgotinib	filgotinib	NOUN
admet-796	132	62	quality	quality	NOUN
admet-796	132	63	controls	control	NOUN
admet-796	132	64	in	in	ADP
admet-796	132	65	rat	rat	NOUN
admet-796	132	66	plasma	plasma	NOUN
admet-796	132	67	rsd	rsd	NOUN
admet-796	132	68	:	:	PUNCT
admet-796	132	69	relative	relative	ADJ
admet-796	132	70	standard	standard	ADJ
admet-796	132	71	deviation	deviation	NOUN
admet-796	132	72	(	(	PUNCT
admet-796	132	73	sd	sd	NOUN
admet-796	132	74	100	100	ADV
admet-796	132	75	/	/	SYM
admet-796	132	76	mean	mean	NOUN
admet-796	132	77	)	)	PUNCT
admet-796	132	78	re	re	ADP
admet-796	132	79	:	:	PUNCT
admet-796	132	80	relative	relative	ADJ
admet-796	132	81	error	error	NOUN
admet-796	132	82	(	(	PUNCT
admet-796	132	83	measured	measure	VERB
admet-796	132	84	value	value	NOUN
admet-796	132	85	/	/	SYM
admet-796	132	86	actual	actual	ADJ
admet-796	132	87	value	value	NOUN
admet-796	132	88	)	)	PUNCT
admet-796	132	89	incurred	incur	VERB
admet-796	132	90	samples	sample	NOUN
admet-796	132	91	reanalysis	reanalysis	NOUN
admet-796	132	92	(	(	PUNCT
admet-796	132	93	isr	isr	NOUN
admet-796	132	94	)	)	PUNCT
admet-796	132	95	as	as	ADP
admet-796	132	96	per	per	ADP
admet-796	132	97	guidance	guidance	NOUN
admet-796	132	98	[	[	X
admet-796	132	99	17	17	NUM
admet-796	132	100	]	]	PUNCT
admet-796	132	101	around	around	ADP
admet-796	132	102	10	10	NUM
admet-796	132	103	%	%	NOUN
admet-796	132	104	of	of	ADP
admet-796	132	105	the	the	DET
admet-796	132	106	study	study	NOUN
admet-796	132	107	samples	sample	NOUN
admet-796	132	108	should	should	AUX
admet-796	132	109	be	be	AUX
admet-796	132	110	selected	select	VERB
admet-796	132	111	for	for	ADP
admet-796	132	112	isr	isr	PROPN
admet-796	132	113	if	if	SCONJ
admet-796	132	114	the	the	DET
admet-796	132	115	total	total	ADJ
admet-796	132	116	sample	sample	NOUN
admet-796	132	117	size	size	NOUN
admet-796	132	118	is	be	AUX
admet-796	132	119	less	less	ADJ
admet-796	132	120	than	than	ADP
admet-796	132	121	1000	1000	NUM
admet-796	132	122	.	.	PUNCT
admet-796	133	1	in	in	ADP
admet-796	133	2	this	this	DET
admet-796	133	3	validation	validation	NOUN
admet-796	133	4	a	a	DET
admet-796	133	5	total	total	NOUN
admet-796	133	6	of	of	ADP
admet-796	133	7	20	20	NUM
admet-796	133	8	samples	sample	NOUN
admet-796	133	9	were	be	AUX
admet-796	133	10	chosen	choose	VERB
admet-796	133	11	for	for	ADP
admet-796	133	12	isr	isr	NOUN
admet-796	133	13	from	from	ADP
admet-796	133	14	the	the	DET
admet-796	133	15	oral	oral	ADJ
admet-796	133	16	and	and	CCONJ
admet-796	133	17	intravenous	intravenous	ADJ
admet-796	133	18	rat	rat	NOUN
admet-796	133	19	pharmacokinetic	pharmacokinetic	ADJ
admet-796	133	20	studies	study	NOUN
admet-796	133	21	.	.	PUNCT
admet-796	134	1	from	from	ADP
admet-796	134	2	oral	oral	ADJ
admet-796	134	3	arm	arm	NOUN
admet-796	134	4	samples	sample	NOUN
admet-796	134	5	near	near	ADP
admet-796	134	6	cmax	cmax	NOUN
admet-796	134	7	(	(	PUNCT
admet-796	134	8	0.5	0.5	NUM
admet-796	134	9	h	h	NOUN
admet-796	134	10	)	)	PUNCT
admet-796	134	11	and	and	CCONJ
admet-796	134	12	elimination	elimination	NOUN
admet-796	134	13	phase	phase	NOUN
admet-796	134	14	(	(	PUNCT
admet-796	134	15	4	4	NUM
admet-796	134	16	h	h	NOUN
admet-796	134	17	and	and	CCONJ
admet-796	134	18	24	24	NUM
admet-796	134	19	h	h	NOUN
admet-796	134	20	)	)	PUNCT
admet-796	134	21	were	be	AUX
admet-796	134	22	selected	select	VERB
admet-796	134	23	.	.	PUNCT
admet-796	135	1	however	however	ADV
admet-796	135	2	,	,	PUNCT
admet-796	135	3	for	for	ADP
admet-796	135	4	intravenous	intravenous	ADJ
admet-796	135	5	arm	arm	NOUN
admet-796	135	6	representative	representative	NOUN
admet-796	135	7	samples	sample	NOUN
admet-796	135	8	at	at	ADP
admet-796	135	9	0.083	0.083	NUM
admet-796	135	10	,	,	PUNCT
admet-796	135	11	2	2	NUM
admet-796	135	12	and	and	CCONJ
admet-796	135	13	8	8	NUM
admet-796	135	14	h	h	NOUN
admet-796	135	15	time	time	NOUN
admet-796	135	16	points	point	NOUN
admet-796	135	17	were	be	AUX
admet-796	135	18	selected	select	VERB
admet-796	135	19	.	.	PUNCT
admet-796	136	1	figure	figure	NOUN
admet-796	136	2	3	3	NUM
admet-796	136	3	shows	show	VERB
admet-796	136	4	the	the	DET
admet-796	136	5	comparison	comparison	NOUN
admet-796	136	6	of	of	ADP
admet-796	136	7	isr	isr	ADJ
admet-796	136	8	values	value	NOUN
admet-796	136	9	versus	versus	ADP
admet-796	136	10	original	original	ADJ
admet-796	136	11	values	value	NOUN
admet-796	136	12	using	use	VERB
admet-796	136	13	blandaltman	blandaltman	PROPN
admet-796	136	14	plot	plot	NOUN
admet-796	136	15	suggesting	suggest	VERB
admet-796	136	16	that	that	SCONJ
admet-796	136	17	all	all	DET
admet-796	136	18	the	the	DET
admet-796	136	19	isr	isr	ADJ
admet-796	136	20	samples	sample	NOUN
admet-796	136	21	were	be	AUX
admet-796	136	22	within	within	ADP
admet-796	136	23	±20	±20	PROPN
admet-796	136	24	%	%	NOUN
admet-796	136	25	of	of	ADP
admet-796	136	26	the	the	DET
admet-796	136	27	original	original	ADJ
admet-796	136	28	values	value	NOUN
admet-796	136	29	.	.	PUNCT
admet-796	137	1	concentration	concentration	NOUN
admet-796	137	2	spiked	spike	VERB
admet-796	137	3	(	(	PUNCT
admet-796	137	4	ng	ng	PROPN
admet-796	137	5	/	/	SYM
admet-796	137	6	ml	ml	NOUN
admet-796	137	7	)	)	PUNCT
admet-796	137	8	bench	bench	NOUN
admet-796	137	9	-	-	PUNCT
admet-796	137	10	top	top	NOUN
admet-796	137	11	for	for	ADP
admet-796	137	12	6	6	NUM
admet-796	137	13	h	h	NOUN
admet-796	137	14	(	(	PUNCT
admet-796	137	15	n=6	n=6	NOUN
admet-796	137	16	)	)	PUNCT
admet-796	137	17	long	long	ADJ
admet-796	137	18	-	-	PUNCT
admet-796	137	19	term	term	NOUN
admet-796	137	20	30	30	NUM
admet-796	137	21	days	day	NOUN
admet-796	137	22	at	at	ADP
admet-796	137	23	-80	-80	NOUN
admet-796	137	24	°	°	ADP
admet-796	137	25	c	c	NOUN
admet-796	137	26	(	(	PUNCT
admet-796	137	27	n=6	n=6	NOUN
admet-796	137	28	)	)	PUNCT
admet-796	137	29	in	in	ADP
admet-796	137	30	-	-	PUNCT
admet-796	137	31	injector	injector	NOUN
admet-796	137	32	for	for	ADP
admet-796	137	33	21	21	NUM
admet-796	137	34	h	h	NOUN
admet-796	137	35	(	(	PUNCT
admet-796	137	36	n=6	n=6	NOUN
admet-796	137	37	)	)	PUNCT
admet-796	137	38	%	%	NOUN
admet-796	137	39	re	re	NOUN
admet-796	137	40	%	%	NOUN
admet-796	137	41	rsd	rsd	PROPN
admet-796	137	42	%	%	NOUN
admet-796	137	43	re	re	NOUN
admet-796	137	44	%	%	NOUN
admet-796	137	45	rsd	rsd	PROPN
admet-796	137	46	%	%	NOUN
admet-796	137	47	re	re	PROPN
admet-796	137	48	%	%	NOUN
admet-796	137	49	rsd	rsd	PROPN
admet-796	137	50	4.01	4.01	NUM
admet-796	137	51	0.96	0.96	NUM
admet-796	137	52	11.1	11.1	NUM
admet-796	137	53	0.97	0.97	NUM
admet-796	137	54	15.1	15.1	NUM
admet-796	137	55	0.91	0.91	NUM
admet-796	137	56	5.99	5.99	NUM
admet-796	137	57	1736	1736	NUM
admet-796	137	58	0.88	0.88	NUM
admet-796	137	59	4.09	4.09	NUM
admet-796	137	60	0.96	0.96	NUM
admet-796	137	61	6.04	6.04	NUM
admet-796	137	62	0.88	0.88	NUM
admet-796	137	63	2.39	2.39	NUM
admet-796	137	64	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PUNCT
admet-796	137	65	r.	r.	PROPN
admet-796	137	66	mullangi	mullangi	AUX
admet-796	137	67	et	et	PROPN
admet-796	137	68	al	al	PROPN
admet-796	137	69	.	.	PROPN
admet-796	137	70	admet	admet	PROPN
admet-796	137	71	&	&	CCONJ
admet-796	137	72	dmpk	dmpk	PROPN
admet-796	137	73	8(2	8(2	NUM
admet-796	137	74	)	)	PUNCT
admet-796	137	75	(	(	PUNCT
admet-796	137	76	2020	2020	NUM
admet-796	137	77	)	)	PUNCT
admet-796	137	78	139	139	NUM
admet-796	137	79	-	-	SYM
admet-796	137	80	148	148	NUM
admet-796	137	81	146	146	NUM
admet-796	137	82	hematocrit	hematocrit	NOUN
admet-796	137	83	effect	effect	NOUN
admet-796	137	84	hematocrit	hematocrit	NOUN
admet-796	137	85	(	(	PUNCT
admet-796	137	86	hct	hct	PROPN
admet-796	137	87	)	)	PUNCT
admet-796	137	88	has	have	VERB
admet-796	137	89	a	a	DET
admet-796	137	90	significant	significant	ADJ
admet-796	137	91	effect	effect	NOUN
admet-796	137	92	on	on	ADP
admet-796	137	93	the	the	DET
admet-796	137	94	viscosity	viscosity	NOUN
admet-796	137	95	of	of	ADP
admet-796	137	96	the	the	DET
admet-796	137	97	blood	blood	NOUN
admet-796	137	98	,	,	PUNCT
admet-796	137	99	which	which	PRON
admet-796	137	100	influences	influence	VERB
admet-796	137	101	the	the	DET
admet-796	137	102	flux	flux	NOUN
admet-796	137	103	and	and	CCONJ
admet-796	137	104	diffusion	diffusion	NOUN
admet-796	137	105	properties	property	NOUN
admet-796	137	106	of	of	ADP
admet-796	137	107	the	the	DET
admet-796	137	108	blood	blood	NOUN
admet-796	137	109	through	through	ADP
admet-796	137	110	dbs	dbs	PROPN
admet-796	137	111	card	card	NOUN
admet-796	137	112	used	use	VERB
admet-796	137	113	for	for	ADP
admet-796	137	114	sample	sample	NOUN
admet-796	137	115	collection	collection	NOUN
admet-796	137	116	.	.	PUNCT
admet-796	138	1	it	it	PRON
admet-796	138	2	can	can	AUX
admet-796	138	3	directly	directly	ADV
admet-796	138	4	affect	affect	VERB
admet-796	138	5	the	the	DET
admet-796	138	6	accuracy	accuracy	NOUN
admet-796	138	7	of	of	ADP
admet-796	138	8	the	the	DET
admet-796	138	9	analysis	analysis	NOUN
admet-796	138	10	in	in	ADP
admet-796	138	11	dbs	dbs	PROPN
admet-796	138	12	samples	sample	NOUN
admet-796	138	13	.	.	PUNCT
admet-796	139	1	the	the	DET
admet-796	139	2	reported	report	VERB
admet-796	139	3	blood	blood	NOUN
admet-796	139	4	-	-	PUNCT
admet-796	139	5	to	to	ADP
admet-796	139	6	-	-	PUNCT
admet-796	139	7	plasma	plasma	NOUN
admet-796	139	8	ratio	ratio	NOUN
admet-796	139	9	for	for	ADP
admet-796	139	10	filgotinib	filgotinib	NOUN
admet-796	139	11	was	be	AUX
admet-796	139	12	1.22	1.22	NUM
admet-796	139	13	[	[	X
admet-796	139	14	19	19	NUM
admet-796	139	15	]	]	PUNCT
admet-796	139	16	indicating	indicate	VERB
admet-796	139	17	an	an	DET
admet-796	139	18	almost	almost	ADV
admet-796	139	19	equal	equal	ADJ
admet-796	139	20	plasma	plasma	NOUN
admet-796	139	21	and	and	CCONJ
admet-796	139	22	red	red	ADJ
admet-796	139	23	blood	blood	NOUN
admet-796	139	24	cell	cell	NOUN
admet-796	139	25	distribution	distribution	NOUN
admet-796	139	26	.	.	PUNCT
admet-796	140	1	the	the	DET
admet-796	140	2	measured	measure	VERB
admet-796	140	3	filgotinib	filgotinib	NOUN
admet-796	140	4	concentrations	concentration	NOUN
admet-796	140	5	were	be	AUX
admet-796	140	6	compared	compare	VERB
admet-796	140	7	with	with	ADP
admet-796	140	8	the	the	DET
admet-796	140	9	results	result	NOUN
admet-796	140	10	obtained	obtain	VERB
admet-796	140	11	from	from	ADP
admet-796	140	12	dbs	dbs	PROPN
admet-796	140	13	samples	sample	NOUN
admet-796	140	14	are	be	AUX
admet-796	140	15	given	give	VERB
admet-796	140	16	in	in	ADP
admet-796	140	17	table	table	NOUN
admet-796	140	18	3	3	NUM
admet-796	140	19	,	,	PUNCT
admet-796	140	20	indicating	indicate	VERB
admet-796	140	21	that	that	SCONJ
admet-796	140	22	hct	hct	PROPN
admet-796	140	23	had	have	VERB
admet-796	140	24	no	no	DET
admet-796	140	25	significant	significant	ADJ
admet-796	140	26	influence	influence	NOUN
admet-796	140	27	on	on	ADP
admet-796	140	28	the	the	DET
admet-796	140	29	filgotinib	filgotinib	ADJ
admet-796	140	30	concentration	concentration	NOUN
admet-796	140	31	.	.	PUNCT
admet-796	141	1	table	table	NOUN
admet-796	141	2	3	3	NUM
admet-796	141	3	.	.	PUNCT
admet-796	142	1	haematocrit	haematocrit	PROPN
admet-796	142	2	effect	effect	NOUN
admet-796	142	3	analysis	analysis	NOUN
admet-796	142	4	concentration	concentration	NOUN
admet-796	142	5	spiked	spike	VERB
admet-796	142	6	(	(	PUNCT
admet-796	142	7	ng	ng	PROPN
admet-796	142	8	/	/	SYM
admet-796	142	9	ml	ml	NOUN
admet-796	142	10	)	)	PUNCT
admet-796	142	11	hematocrit	hematocrit	NOUN
admet-796	142	12	(	(	PUNCT
admet-796	142	13	%	%	INTJ
admet-796	142	14	)	)	PUNCT
admet-796	142	15	concentration	concentration	NOUN
admet-796	142	16	found	find	VERB
admet-796	142	17	(	(	PUNCT
admet-796	142	18	ng	ng	NOUN
admet-796	142	19	/	/	SYM
admet-796	142	20	ml	ml	NOUN
admet-796	142	21	)	)	PUNCT
admet-796	142	22	accuracy	accuracy	NOUN
admet-796	142	23	(	(	PUNCT
admet-796	142	24	%	%	INTJ
admet-796	142	25	re	re	NOUN
admet-796	142	26	)	)	PUNCT
admet-796	142	27	precision	precision	NOUN
admet-796	142	28	(	(	PUNCT
admet-796	142	29	%	%	NOUN
admet-796	142	30	rsd	rsd	NOUN
admet-796	142	31	)	)	PUNCT
admet-796	142	32	4.01	4.01	NUM
admet-796	142	33	30	30	NUM
admet-796	142	34	3.95	3.95	NUM
admet-796	142	35	±	±	NUM
admet-796	142	36	0.19	0.19	NUM
admet-796	142	37	0.98	0.98	NUM
admet-796	142	38	4.81	4.81	NUM
admet-796	142	39	50	50	NUM
admet-796	142	40	3.90	3.90	NUM
admet-796	142	41	±	±	NUM
admet-796	142	42	0.24	0.24	NUM
admet-796	142	43	0.97	0.97	NUM
admet-796	142	44	6.29	6.29	NUM
admet-796	142	45	1736	1736	NUM
admet-796	142	46	30	30	NUM
admet-796	142	47	1664	1664	NUM
admet-796	142	48	±	±	NUM
admet-796	142	49	80.4	80.4	NUM
admet-796	142	50	0.95	0.95	NUM
admet-796	142	51	4.83	4.83	NUM
admet-796	142	52	50	50	NUM
admet-796	142	53	1786	1786	NUM
admet-796	142	54	±	±	NOUN
admet-796	142	55	88.7	88.7	NUM
admet-796	142	56	1.02	1.02	NUM
admet-796	142	57	4.96	4.96	NUM
admet-796	142	58	0	0	NUM
admet-796	142	59	2	2	NUM
admet-796	142	60	4	4	NUM
admet-796	142	61	6	6	NUM
admet-796	142	62	8	8	NUM
admet-796	142	63	10	10	NUM
admet-796	142	64	12	12	NUM
admet-796	142	65	14	14	NUM
admet-796	142	66	16	16	NUM
admet-796	142	67	18	18	NUM
admet-796	142	68	20	20	NUM
admet-796	142	69	22	22	NUM
admet-796	142	70	24	24	NUM
admet-796	142	71	1	1	NUM
admet-796	142	72	10	10	NUM
admet-796	142	73	100	100	NUM
admet-796	142	74	1000	1000	NUM
admet-796	142	75	10000	10000	NUM
admet-796	142	76	time	time	NOUN
admet-796	142	77	(	(	PUNCT
admet-796	142	78	h	h	NOUN
admet-796	142	79	)	)	PUNCT
admet-796	142	80	m	m	VERB
admet-796	142	81	ea	ea	NOUN
admet-796	142	82	n	n	NUM
admet-796	142	83	±	±	PROPN
admet-796	142	84	s	s	PART
admet-796	142	85	.d	.d	NOUN
admet-796	142	86	(	(	PUNCT
admet-796	142	87	n	n	CCONJ
admet-796	142	88	g	g	NOUN
admet-796	142	89	/m	/m	PUNCT
admet-796	142	90	l	l	NOUN
admet-796	142	91	)	)	PUNCT
admet-796	143	1	c	c	X
admet-796	144	1	o	o	NOUN
admet-796	144	2	n	n	X
admet-796	144	3	c	c	X
admet-796	144	4	en	en	X
admet-796	144	5	tr	tr	VERB
admet-796	144	6	at	at	ADP
admet-796	144	7	io	io	PROPN
admet-796	144	8	n	n	PRON
admet-796	145	1	o	o	NOUN
admet-796	145	2	f	f	X
admet-796	145	3	fi	fi	NOUN
admet-796	145	4	lg	lg	NOUN
admet-796	145	5	o	o	NOUN
admet-796	145	6	ti	ti	NOUN
admet-796	145	7	n	n	CCONJ
admet-796	145	8	ib	ib	NOUN
admet-796	145	9	iv	iv	NUM
admet-796	145	10	2	2	NUM
admet-796	145	11	mg	mg	PROPN
admet-796	145	12	/	/	SYM
admet-796	145	13	kg	kg	PROPN
admet-796	145	14	plasma	plasma	NOUN
admet-796	145	15	iv	iv	NUM
admet-796	145	16	2	2	NUM
admet-796	145	17	mg	mg	PROPN
admet-796	145	18	/	/	SYM
admet-796	145	19	kg	kg	NOUN
admet-796	145	20	dbs	dbs	PROPN
admet-796	145	21	0	0	NUM
admet-796	145	22	2	2	NUM
admet-796	145	23	4	4	NUM
admet-796	145	24	6	6	NUM
admet-796	145	25	8	8	NUM
admet-796	145	26	10	10	NUM
admet-796	145	27	12	12	NUM
admet-796	145	28	14	14	NUM
admet-796	145	29	16	16	NUM
admet-796	145	30	18	18	NUM
admet-796	145	31	20	20	NUM
admet-796	145	32	22	22	NUM
admet-796	145	33	24	24	NUM
admet-796	145	34	1	1	NUM
admet-796	145	35	10	10	NUM
admet-796	145	36	100	100	NUM
admet-796	145	37	1000	1000	NUM
admet-796	145	38	10000	10000	NUM
admet-796	145	39	time	time	NOUN
admet-796	145	40	(	(	PUNCT
admet-796	145	41	h	h	NOUN
admet-796	145	42	)	)	PUNCT
admet-796	145	43	m	m	VERB
admet-796	145	44	ea	ea	NOUN
admet-796	145	45	n	n	NUM
admet-796	145	46	±	±	PROPN
admet-796	145	47	s	s	PART
admet-796	145	48	.d	.d	NOUN
admet-796	145	49	(	(	PUNCT
admet-796	145	50	n	n	CCONJ
admet-796	145	51	g	g	NOUN
admet-796	145	52	/m	/m	PUNCT
admet-796	145	53	l	l	NOUN
admet-796	145	54	)	)	PUNCT
admet-796	146	1	c	c	X
admet-796	147	1	o	o	NOUN
admet-796	147	2	n	n	X
admet-796	147	3	c	c	X
admet-796	147	4	en	en	X
admet-796	147	5	tr	tr	VERB
admet-796	147	6	at	at	ADP
admet-796	147	7	io	io	PROPN
admet-796	147	8	n	n	PRON
admet-796	147	9	o	o	NOUN
admet-796	147	10	f	f	X
admet-796	147	11	fi	fi	NOUN
admet-796	147	12	lg	lg	NOUN
admet-796	147	13	o	o	NOUN
admet-796	147	14	ti	ti	NOUN
admet-796	147	15	n	n	ADV
admet-796	147	16	ib	ib	NOUN
admet-796	147	17	po	po	PROPN
admet-796	147	18	10	10	NUM
admet-796	147	19	mg	mg	PROPN
admet-796	147	20	/	/	SYM
admet-796	147	21	kg	kg	PROPN
admet-796	147	22	plasma	plasma	NOUN
admet-796	147	23	po	po	PROPN
admet-796	147	24	10	10	NUM
admet-796	147	25	mg	mg	NUM
admet-796	147	26	/	/	SYM
admet-796	147	27	kg	kg	NOUN
admet-796	147	28	dbs	dbs	PROPN
admet-796	147	29	figure	figure	NOUN
admet-796	147	30	4	4	NUM
admet-796	147	31	.	.	PUNCT
admet-796	147	32	a	a	X
admet-796	147	33	)	)	PUNCT
admet-796	147	34	mean	mean	ADJ
admet-796	147	35	plasma	plasma	NOUN
admet-796	147	36	concentration	concentration	NOUN
admet-796	147	37	-	-	PUNCT
admet-796	147	38	time	time	NOUN
admet-796	147	39	profiles	profile	NOUN
admet-796	147	40	of	of	ADP
admet-796	147	41	filgotinib	filgotinib	NOUN
admet-796	147	42	in	in	ADP
admet-796	147	43	rat	rat	NOUN
admet-796	147	44	blood	blood	NOUN
admet-796	147	45	and	and	CCONJ
admet-796	147	46	plasma	plasma	NOUN
admet-796	147	47	following	follow	VERB
admet-796	147	48	intravenous	intravenous	ADJ
admet-796	147	49	administration	administration	NOUN
admet-796	147	50	of	of	ADP
admet-796	147	51	filgotinib	filgotinib	PROPN
admet-796	147	52	;	;	PUNCT
admet-796	147	53	b	b	X
admet-796	147	54	)	)	PUNCT
admet-796	147	55	mean	mean	ADJ
admet-796	147	56	plasma	plasma	NOUN
admet-796	147	57	concentration	concentration	NOUN
admet-796	147	58	-	-	PUNCT
admet-796	147	59	time	time	NOUN
admet-796	147	60	profiles	profile	NOUN
admet-796	147	61	of	of	ADP
admet-796	147	62	filgotinib	filgotinib	NOUN
admet-796	147	63	in	in	ADP
admet-796	147	64	rat	rat	NOUN
admet-796	147	65	blood	blood	NOUN
admet-796	147	66	and	and	CCONJ
admet-796	147	67	plasma	plasma	NOUN
admet-796	147	68	following	follow	VERB
admet-796	147	69	oral	oral	ADJ
admet-796	147	70	administration	administration	NOUN
admet-796	147	71	of	of	ADP
admet-796	147	72	filgotinib	filgotinib	PROPN
admet-796	147	73	.	.	PUNCT
admet-796	148	1	pharmacokinetic	pharmacokinetic	ADJ
admet-796	148	2	study	study	NOUN
admet-796	148	3	the	the	DET
admet-796	148	4	sensitivity	sensitivity	NOUN
admet-796	148	5	of	of	ADP
admet-796	148	6	the	the	DET
admet-796	148	7	present	present	ADJ
admet-796	148	8	dbs	dbs	NOUN
admet-796	148	9	method	method	NOUN
admet-796	148	10	was	be	AUX
admet-796	148	11	found	find	VERB
admet-796	148	12	to	to	PART
admet-796	148	13	be	be	AUX
admet-796	148	14	sufficient	sufficient	ADJ
admet-796	148	15	for	for	ADP
admet-796	148	16	accurately	accurately	ADV
admet-796	148	17	characterizing	characterize	VERB
admet-796	148	18	the	the	DET
admet-796	148	19	pharmacokinetics	pharmacokinetic	NOUN
admet-796	148	20	of	of	ADP
admet-796	148	21	filgotinib	filgotinib	NOUN
admet-796	148	22	by	by	ADP
admet-796	148	23	oral	oral	ADJ
admet-796	148	24	and	and	CCONJ
admet-796	148	25	intravenous	intravenous	ADJ
admet-796	148	26	routes	route	NOUN
admet-796	148	27	in	in	ADP
admet-796	148	28	rats	rat	NOUN
admet-796	148	29	.	.	PUNCT
admet-796	149	1	to	to	PART
admet-796	149	2	assure	assure	VERB
admet-796	149	3	acceptance	acceptance	NOUN
admet-796	149	4	of	of	ADP
admet-796	149	5	study	study	NOUN
admet-796	149	6	sample	sample	NOUN
admet-796	149	7	analytical	analytical	ADJ
admet-796	149	8	runs	run	NOUN
admet-796	149	9	,	,	PUNCT
admet-796	149	10	at	at	ADV
admet-796	149	11	least	least	ADJ
admet-796	149	12	two	two	NUM
admet-796	149	13	-	-	PUNCT
admet-796	149	14	thirds	third	NOUN
admet-796	149	15	of	of	ADP
admet-796	149	16	the	the	DET
admet-796	149	17	qc	qc	PROPN
admet-796	149	18	samples	sample	NOUN
admet-796	149	19	had	have	VERB
admet-796	149	20	to	to	PART
admet-796	149	21	be	be	AUX
admet-796	149	22	within	within	ADP
admet-796	149	23	±15	±15	NOUN
admet-796	149	24	%	%	NOUN
admet-796	149	25	accuracy	accuracy	NOUN
admet-796	149	26	,	,	PUNCT
admet-796	149	27	with	with	ADP
admet-796	149	28	at	at	ADV
admet-796	149	29	least	least	ADJ
admet-796	149	30	half	half	NOUN
admet-796	149	31	of	of	ADP
admet-796	149	32	the	the	DET
admet-796	149	33	qc	qc	PROPN
admet-796	149	34	samples	sample	NOUN
admet-796	149	35	at	at	ADP
admet-796	149	36	each	each	DET
admet-796	149	37	concentration	concentration	NOUN
admet-796	149	38	meeting	meet	VERB
admet-796	149	39	these	these	DET
admet-796	149	40	criteria	criterion	NOUN
admet-796	149	41	.	.	PUNCT
admet-796	150	1	results	result	NOUN
admet-796	150	2	indicated	indicate	VERB
admet-796	150	3	that	that	SCONJ
admet-796	150	4	qcs	qcs	PROPN
admet-796	150	5	met	meet	VERB
admet-796	150	6	the	the	DET
admet-796	150	7	acceptance	acceptance	NOUN
admet-796	150	8	criteria	criterion	NOUN
admet-796	150	9	.	.	PUNCT
admet-796	151	1	figures	figure	NOUN
admet-796	151	2	4a	4a	NOUN
admet-796	151	3	and	and	CCONJ
admet-796	151	4	4b	4b	PROPN
admet-796	151	5	show	show	VERB
admet-796	151	6	the	the	DET
admet-796	151	7	mean	mean	ADJ
admet-796	151	8	blood	blood	NOUN
admet-796	151	9	concentration	concentration	NOUN
admet-796	151	10	versus	versus	ADP
admet-796	151	11	time	time	NOUN
admet-796	151	12	for	for	ADP
admet-796	151	13	filgotinib	filgotinib	PROPN
admet-796	151	14	post	post	PROPN
admet-796	151	15	administration	administration	NOUN
admet-796	151	16	of	of	ADP
admet-796	151	17	intravenous	intravenous	ADJ
admet-796	151	18	and	and	CCONJ
admet-796	151	19	oral	oral	ADJ
admet-796	151	20	route	route	NOUN
admet-796	151	21	,	,	PUNCT
admet-796	151	22	respectively	respectively	ADV
admet-796	151	23	in	in	ADP
admet-796	151	24	rats	rat	NOUN
admet-796	151	25	.	.	PUNCT
admet-796	152	1	the	the	DET
admet-796	152	2	pharmacokinetic	pharmacokinetic	ADJ
admet-796	152	3	parameters	parameter	NOUN
admet-796	152	4	are	be	AUX
admet-796	152	5	summarized	summarize	VERB
admet-796	152	6	in	in	ADP
admet-796	152	7	table	table	NOUN
admet-796	152	8	4	4	NUM
admet-796	152	9	along	along	ADV
admet-796	152	10	with	with	ADP
admet-796	152	11	previously	previously	ADV
admet-796	152	12	reported	report	VERB
admet-796	152	13	pharmacokinetic	pharmacokinetic	ADJ
admet-796	152	14	parameters	parameter	NOUN
admet-796	152	15	by	by	ADP
admet-796	152	16	dixit	dixit	PROPN
admet-796	152	17	et	et	PROPN
admet-796	152	18	al	al	PROPN
admet-796	152	19	.	.	PUNCT
admet-796	153	1	[	[	X
admet-796	153	2	10	10	NUM
admet-796	153	3	]	]	PUNCT
admet-796	153	4	.	.	PUNCT
admet-796	154	1	filgotinib	filgotinib	PROPN
admet-796	154	2	was	be	AUX
admet-796	154	3	quantifiable	quantifiable	ADJ
admet-796	154	4	up	up	ADP
admet-796	154	5	to	to	PART
admet-796	154	6	24	24	NUM
admet-796	154	7	h	h	NOUN
admet-796	154	8	post	post	VERB
admet-796	154	9	intravenous	intravenous	ADJ
admet-796	154	10	and	and	CCONJ
admet-796	154	11	oral	oral	ADJ
admet-796	154	12	administration	administration	NOUN
admet-796	154	13	to	to	ADP
admet-796	154	14	rats	rat	NOUN
admet-796	154	15	.	.	PUNCT
admet-796	155	1	following	follow	VERB
admet-796	155	2	intravenous	intravenous	ADJ
admet-796	155	3	administration	administration	NOUN
admet-796	155	4	at	at	ADP
admet-796	155	5	2.0	2.0	NUM
admet-796	155	6	mg	mg	PROPN
admet-796	155	7	/	/	SYM
admet-796	155	8	kg	kg	PROPN
admet-796	155	9	,	,	PUNCT
admet-796	155	10	the	the	DET
admet-796	155	11	plasma	plasma	NOUN
admet-796	155	12	concentrations	concentration	NOUN
admet-796	155	13	decreased	decrease	VERB
admet-796	155	14	mono	mono	NOUN
admet-796	155	15	-	-	PUNCT
admet-796	155	16	exponentially	exponentially	ADV
admet-796	155	17	.	.	PUNCT
admet-796	156	1	filgotinib	filgotinib	PROPN
admet-796	156	2	exhibited	exhibit	VERB
admet-796	156	3	moderate	moderate	ADJ
admet-796	156	4	clearance	clearance	NOUN
admet-796	156	5	(	(	PUNCT
admet-796	156	6	cl	cl	NOUN
admet-796	156	7	)	)	PUNCT
admet-796	156	8	of	of	ADP
admet-796	156	9	18.7	18.7	NUM
admet-796	156	10	±	±	NUM
admet-796	156	11	1.86	1.86	NUM
admet-796	156	12	ml	ml	NOUN
admet-796	156	13	/	/	SYM
admet-796	156	14	min	min	NOUN
admet-796	156	15	/	/	SYM
admet-796	156	16	kg	kg	PROPN
admet-796	156	17	,	,	PUNCT
admet-796	156	18	which	which	PRON
admet-796	156	19	is	be	AUX
admet-796	156	20	~3	~3	ADJ
admet-796	156	21	-	-	ADJ
admet-796	156	22	fold	fold	VERB
admet-796	156	23	lower	low	ADJ
admet-796	156	24	than	than	ADP
admet-796	156	25	hepatic	hepatic	ADJ
admet-796	156	26	blood	blood	NOUN
admet-796	156	27	flow	flow	NOUN
admet-796	156	28	(	(	PUNCT
admet-796	156	29	55	55	NUM
admet-796	156	30	ml	ml	NOUN
admet-796	156	31	/	/	SYM
admet-796	156	32	min	min	NOUN
admet-796	156	33	/	/	SYM
admet-796	156	34	kg	kg	NOUN
admet-796	156	35	)	)	PUNCT
admet-796	156	36	and	and	CCONJ
admet-796	156	37	volume	volume	NOUN
admet-796	156	38	of	of	ADP
admet-796	156	39	distribution	distribution	NOUN
admet-796	156	40	(	(	PUNCT
admet-796	156	41	vd	vd	NOUN
admet-796	156	42	)	)	PUNCT
admet-796	156	43	was	be	AUX
admet-796	156	44	4.17	4.17	NUM
admet-796	156	45	±	±	NUM
admet-796	156	46	0.33	0.33	NUM
admet-796	156	47	l	l	NOUN
admet-796	156	48	/	/	SYM
admet-796	156	49	kg	kg	X
admet-796	156	50	in	in	ADP
admet-796	156	51	rats	rat	NOUN
admet-796	156	52	.	.	PUNCT
admet-796	157	1	the	the	DET
admet-796	157	2	terminal	terminal	ADJ
admet-796	157	3	halflife	halflife	NOUN
admet-796	157	4	was	be	AUX
admet-796	157	5	found	find	VERB
admet-796	157	6	to	to	PART
admet-796	157	7	be	be	AUX
admet-796	157	8	3.52	3.52	NUM
admet-796	157	9	±	±	NUM
admet-796	157	10	0.23	0.23	NUM
admet-796	157	11	h.	h.	PROPN
admet-796	157	12	following	follow	VERB
admet-796	157	13	oral	oral	ADJ
admet-796	157	14	administration	administration	NOUN
admet-796	157	15	filgotinib	filgotinib	VERB
admet-796	157	16	maximum	maximum	ADJ
admet-796	157	17	plasma	plasma	NOUN
admet-796	157	18	concentrations	concentration	NOUN
admet-796	157	19	(	(	PUNCT
admet-796	157	20	cmax	cmax	NOUN
admet-796	157	21	:	:	PUNCT
admet-796	157	22	804	804	NUM
admet-796	157	23	±	±	NUM
admet-796	157	24	78.4	78.4	NUM
admet-796	157	25	ng	ng	PROPN
admet-796	157	26	/	/	SYM
admet-796	157	27	ml	ml	PROPN
admet-796	157	28	)	)	PUNCT
admet-796	157	29	attained	attain	VERB
admet-796	157	30	at	at	ADP
admet-796	157	31	0.50	0.50	NUM
admet-796	157	32	±	±	NUM
admet-796	157	33	0.00	0.00	NUM
admet-796	157	34	h	h	NOUN
admet-796	157	35	(	(	PUNCT
admet-796	157	36	tmax	tmax	ADV
admet-796	157	37	)	)	PUNCT
admet-796	157	38	in	in	ADP
admet-796	157	39	all	all	DET
admet-796	157	40	rats	rat	NOUN
admet-796	157	41	suggesting	suggest	VERB
admet-796	157	42	that	that	SCONJ
admet-796	157	43	filgotinib	filgotinib	NOUN
admet-796	157	44	has	have	VERB
admet-796	157	45	a	a	DET
admet-796	157	46	rapid	rapid	ADJ
admet-796	157	47	a	a	DET
admet-796	157	48	)	)	PUNCT
admet-796	157	49	b	b	NOUN
admet-796	157	50	)	)	PUNCT
admet-796	157	51	admet	admet	PROPN
admet-796	157	52	&	&	CCONJ
admet-796	157	53	dmpk	dmpk	PROPN
admet-796	157	54	8(2	8(2	NUM
admet-796	157	55	)	)	PUNCT
admet-796	157	56	(	(	PUNCT
admet-796	157	57	2020	2020	NUM
admet-796	157	58	)	)	PUNCT
admet-796	157	59	139	139	NUM
admet-796	157	60	-	-	SYM
admet-796	157	61	148	148	NUM
admet-796	157	62	dbs	dbs	NOUN
admet-796	157	63	method	method	NOUN
admet-796	157	64	for	for	ADP
admet-796	157	65	filgotinib	filgotinib	ADJ
admet-796	157	66	quantitation	quantitation	NOUN
admet-796	157	67	doi	doi	NOUN
admet-796	157	68	:	:	PUNCT
admet-796	157	69	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	NOUN
admet-796	157	70	147	147	NUM
admet-796	157	71	absorption	absorption	NOUN
admet-796	157	72	from	from	ADP
admet-796	157	73	the	the	DET
admet-796	157	74	gastrointestinal	gastrointestinal	ADJ
admet-796	157	75	tract	tract	NOUN
admet-796	157	76	.	.	PUNCT
admet-796	158	1	the	the	DET
admet-796	158	2	auc0-	auc0-	NOUN
admet-796	158	3	(	(	PUNCT
admet-796	158	4	area	area	NOUN
admet-796	158	5	under	under	ADP
admet-796	158	6	the	the	DET
admet-796	158	7	plasma	plasma	NOUN
admet-796	158	8	concentration	concentration	NOUN
admet-796	158	9	-	-	PUNCT
admet-796	158	10	time	time	NOUN
admet-796	158	11	curve	curve	NOUN
admet-796	158	12	from	from	ADP
admet-796	158	13	time	time	NOUN
admet-796	158	14	zero	zero	NUM
admet-796	158	15	to	to	ADP
admet-796	158	16	infinity	infinity	NOUN
admet-796	158	17	)	)	PUNCT
admet-796	158	18	was	be	AUX
admet-796	158	19	found	find	VERB
admet-796	158	20	to	to	PART
admet-796	158	21	be	be	AUX
admet-796	158	22	3722	3722	NUM
admet-796	158	23	±	±	NUM
admet-796	158	24	329	329	NUM
admet-796	158	25	and	and	CCONJ
admet-796	158	26	1801	1801	NUM
admet-796	158	27	±	±	NUM
admet-796	158	28	188	188	NUM
admet-796	158	29	ngh	ngh	NOUN
admet-796	158	30	/	/	SYM
admet-796	158	31	ml	ml	NOUN
admet-796	158	32	,	,	PUNCT
admet-796	158	33	by	by	ADP
admet-796	158	34	oral	oral	ADJ
admet-796	158	35	and	and	CCONJ
admet-796	158	36	intravenous	intravenous	ADJ
admet-796	158	37	routes	route	NOUN
admet-796	158	38	,	,	PUNCT
admet-796	158	39	respectively	respectively	ADV
admet-796	158	40	.	.	PUNCT
admet-796	159	1	the	the	DET
admet-796	159	2	terminal	terminal	ADJ
admet-796	159	3	half	half	ADJ
admet-796	159	4	-	-	PUNCT
admet-796	159	5	life	life	NOUN
admet-796	159	6	(	(	PUNCT
admet-796	159	7	t½	t½	NOUN
admet-796	159	8	)	)	PUNCT
admet-796	159	9	determined	determine	VERB
admet-796	159	10	after	after	SCONJ
admet-796	159	11	oral	oral	ADJ
admet-796	159	12	administration	administration	NOUN
admet-796	159	13	was	be	AUX
admet-796	159	14	4.87	4.87	NUM
admet-796	159	15	±	±	NUM
admet-796	159	16	0.45	0.45	NUM
admet-796	159	17	h.	h.	NOUN
admet-796	159	18	the	the	DET
admet-796	159	19	absolute	absolute	ADJ
admet-796	159	20	oral	oral	ADJ
admet-796	159	21	bioavailability	bioavailability	NOUN
admet-796	159	22	for	for	ADP
admet-796	159	23	filgotinib	filgotinib	NOUN
admet-796	159	24	in	in	ADP
admet-796	159	25	rats	rat	NOUN
admet-796	159	26	at	at	ADP
admet-796	159	27	10	10	NUM
admet-796	159	28	mg	mg	NOUN
admet-796	159	29	/	/	SYM
admet-796	159	30	kg	kg	PROPN
admet-796	159	31	was	be	AUX
admet-796	159	32	42.5	42.5	NUM
admet-796	159	33	%	%	NOUN
admet-796	159	34	.	.	PUNCT
admet-796	160	1	table	table	NOUN
admet-796	160	2	4	4	NUM
admet-796	160	3	.	.	PUNCT
admet-796	160	4	pharmacokinetic	pharmacokinetic	ADJ
admet-796	160	5	parameters	parameter	NOUN
admet-796	160	6	for	for	ADP
admet-796	160	7	filgotinib	filgotinib	NOUN
admet-796	160	8	in	in	ADP
admet-796	160	9	rats	rat	NOUN
admet-796	160	10	following	follow	VERB
admet-796	160	11	oral	oral	ADJ
admet-796	160	12	and	and	CCONJ
admet-796	160	13	intravenous	intravenous	ADJ
admet-796	160	14	administration	administration	NOUN
admet-796	160	15	pk	pk	PROPN
admet-796	160	16	parameters	parameter	NOUN
admet-796	160	17	oral	oral	VERB
admet-796	160	18	intravenous	intravenous	ADJ
admet-796	160	19	dose	dose	NOUN
admet-796	160	20	(	(	PUNCT
admet-796	160	21	mg	mg	PROPN
admet-796	160	22	/	/	SYM
admet-796	160	23	kg	kg	NOUN
admet-796	160	24	)	)	PUNCT
admet-796	160	25	10	10	NUM
admet-796	160	26	2.0	2.0	NUM
admet-796	160	27	auc(0-	auc(0-	NUM
admet-796	160	28	)	)	PUNCT
admet-796	160	29	(	(	PUNCT
admet-796	160	30	ng	ng	PROPN
admet-796	160	31			PROPN
admet-796	160	32	h	h	PROPN
admet-796	160	33	/	/	SYM
admet-796	160	34	ml	ml	NOUN
admet-796	160	35	)	)	PUNCT
admet-796	160	36	3722	3722	NUM
admet-796	160	37	±	±	NUM
admet-796	160	38	329	329	NUM
admet-796	160	39	(	(	PUNCT
admet-796	160	40	3475	3475	NUM
admet-796	160	41	±	±	NUM
admet-796	160	42	547	547	NUM
admet-796	160	43	)	)	PUNCT
admet-796	160	44	1801	1801	NUM
admet-796	160	45	±	±	NUM
admet-796	160	46	188	188	NUM
admet-796	160	47	(	(	PUNCT
admet-796	160	48	1912	1912	NUM
admet-796	160	49	±	±	NUM
admet-796	160	50	123	123	NUM
admet-796	160	51	)	)	PUNCT
admet-796	160	52	cmax	cmax	NOUN
admet-796	160	53	/	/	SYM
admet-796	160	54	c0	c0	PROPN
admet-796	160	55	(	(	PUNCT
admet-796	160	56	ng	ng	PROPN
admet-796	160	57	/	/	SYM
admet-796	160	58	ml	ml	PROPN
admet-796	160	59	)	)	PUNCT
admet-796	160	60	804	804	NUM
admet-796	160	61	±	±	NUM
admet-796	160	62	78.4	78.4	NUM
admet-796	160	63	(	(	PUNCT
admet-796	160	64	802	802	NUM
admet-796	160	65	±	±	NUM
admet-796	160	66	149	149	NUM
admet-796	160	67	)	)	PUNCT
admet-796	160	68	1602	1602	NUM
admet-796	160	69	±	±	NUM
admet-796	160	70	55.5	55.5	NUM
admet-796	160	71	(	(	PUNCT
admet-796	160	72	1767	1767	NUM
admet-796	160	73	±	±	NUM
admet-796	160	74	128	128	NUM
admet-796	160	75	)	)	PUNCT
admet-796	161	1	tmax	tmax	ADV
admet-796	161	2	(	(	PUNCT
admet-796	161	3	h	h	NOUN
admet-796	161	4	)	)	PUNCT
admet-796	161	5	0.50	0.50	NUM
admet-796	161	6	±	±	NUM
admet-796	161	7	0.00	0.00	NUM
admet-796	161	8	(	(	PUNCT
admet-796	161	9	0.50	0.50	NUM
admet-796	161	10	±	±	NUM
admet-796	161	11	0.00	0.00	NUM
admet-796	161	12	)	)	PUNCT
admet-796	161	13	--	--	PUNCT
admet-796	162	1	t1/2	t1/2	VERB
admet-796	162	2	(	(	PUNCT
admet-796	162	3	h	h	NOUN
admet-796	162	4	)	)	PUNCT
admet-796	162	5	4.87	4.87	NUM
admet-796	162	6	±	±	NUM
admet-796	162	7	0.45	0.45	NUM
admet-796	162	8	(	(	PUNCT
admet-796	162	9	4.72	4.72	NUM
admet-796	162	10	±	±	NUM
admet-796	162	11	0.24	0.24	NUM
admet-796	162	12	)	)	PUNCT
admet-796	162	13	3.52	3.52	NUM
admet-796	162	14	±	±	NUM
admet-796	162	15	0.23	0.23	NUM
admet-796	162	16	(	(	PUNCT
admet-796	162	17	3.56	3.56	NUM
admet-796	162	18	±	±	NUM
admet-796	162	19	0.30	0.30	NUM
admet-796	162	20	)	)	PUNCT
admet-796	162	21	cl	cl	NOUN
admet-796	162	22	(	(	PUNCT
admet-796	162	23	ml	ml	NOUN
admet-796	162	24	/	/	SYM
admet-796	162	25	min	min	NOUN
admet-796	162	26	/	/	SYM
admet-796	162	27	kg	kg	NOUN
admet-796	162	28	)	)	PUNCT
admet-796	162	29	--	--	PUNCT
admet-796	162	30	18.7	18.7	NUM
admet-796	162	31	±	±	NUM
admet-796	162	32	1.86	1.86	NUM
admet-796	162	33	(	(	PUNCT
admet-796	162	34	17.4	17.4	NUM
admet-796	162	35	±	±	NUM
admet-796	162	36	1.08	1.08	NUM
admet-796	162	37	)	)	PUNCT
admet-796	162	38	vd	vd	NOUN
admet-796	162	39	(	(	PUNCT
admet-796	162	40	l	l	NOUN
admet-796	162	41	/	/	SYM
admet-796	162	42	kg	kg	NOUN
admet-796	162	43	)	)	PUNCT
admet-796	162	44	--	--	PUNCT
admet-796	162	45	4.17	4.17	NUM
admet-796	162	46	±	±	NUM
admet-796	162	47	0.33	0.33	NUM
admet-796	162	48	(	(	PUNCT
admet-796	162	49	5.41	5.41	NUM
admet-796	162	50	±	±	NUM
admet-796	162	51	0.77	0.77	NUM
admet-796	162	52	)	)	PUNCT
admet-796	162	53	f	f	PROPN
admet-796	163	1	(	(	PUNCT
admet-796	163	2	%	%	INTJ
admet-796	163	3	)	)	PUNCT
admet-796	163	4	42.5	42.5	NUM
admet-796	163	5	(	(	PUNCT
admet-796	163	6	36.3	36.3	NUM
admet-796	163	7	)	)	PUNCT
admet-796	163	8	--	--	PUNCT
admet-796	163	9	the	the	DET
admet-796	163	10	values	value	NOUN
admet-796	163	11	in	in	ADP
admet-796	163	12	parentheses	parenthesis	NOUN
admet-796	163	13	are	be	AUX
admet-796	163	14	reported	report	VERB
admet-796	163	15	by	by	ADP
admet-796	163	16	dixit	dixit	PROPN
admet-796	163	17	et	et	PROPN
admet-796	163	18	al	al	PROPN
admet-796	163	19	.	.	PROPN
admet-796	164	1	(	(	PUNCT
admet-796	164	2	2020	2020	NUM
admet-796	164	3	)	)	PUNCT
admet-796	165	1	[	[	X
admet-796	165	2	10	10	NUM
admet-796	165	3	]	]	PUNCT
admet-796	165	4	.	.	PUNCT
admet-796	166	1	in	in	ADP
admet-796	166	2	figures	figure	NOUN
admet-796	166	3	4a	4a	NOUN
admet-796	166	4	and	and	CCONJ
admet-796	166	5	4b	4b	NUM
admet-796	166	6	the	the	DET
admet-796	166	7	blood	blood	NOUN
admet-796	166	8	versus	versus	ADP
admet-796	166	9	time	time	NOUN
admet-796	166	10	concentration	concentration	NOUN
admet-796	166	11	profiles	profile	NOUN
admet-796	166	12	of	of	ADP
admet-796	166	13	filgotinib	filgotinib	NOUN
admet-796	166	14	obtained	obtain	VERB
admet-796	166	15	from	from	ADP
admet-796	166	16	intravenous	intravenous	ADJ
admet-796	166	17	and	and	CCONJ
admet-796	166	18	oral	oral	ADJ
admet-796	166	19	routes	route	NOUN
admet-796	166	20	in	in	ADP
admet-796	166	21	rats	rat	NOUN
admet-796	166	22	were	be	AUX
admet-796	166	23	presented	present	VERB
admet-796	166	24	along	along	ADP
admet-796	166	25	with	with	ADP
admet-796	166	26	plasma	plasma	NOUN
admet-796	166	27	versus	versus	ADP
admet-796	166	28	time	time	NOUN
admet-796	166	29	concentration	concentration	NOUN
admet-796	166	30	profiles	profile	NOUN
admet-796	166	31	reported	report	VERB
admet-796	166	32	earlier	early	ADV
admet-796	166	33	by	by	ADP
admet-796	166	34	us	we	PRON
admet-796	167	1	[	[	X
admet-796	167	2	10	10	NUM
admet-796	167	3	]	]	PUNCT
admet-796	167	4	showed	show	VERB
admet-796	167	5	excellent	excellent	ADJ
admet-796	167	6	correlation	correlation	NOUN
admet-796	167	7	(	(	PUNCT
admet-796	167	8	r2	r2	PROPN
admet-796	167	9	>	>	X
admet-796	167	10	0.99	0.99	NUM
admet-796	167	11	)	)	PUNCT
admet-796	167	12	.	.	PUNCT
admet-796	168	1	this	this	PRON
admet-796	168	2	indicates	indicate	VERB
admet-796	168	3	that	that	SCONJ
admet-796	168	4	dbs	dbs	PROPN
admet-796	168	5	can	can	AUX
admet-796	168	6	be	be	AUX
admet-796	168	7	used	use	VERB
admet-796	168	8	as	as	ADP
admet-796	168	9	an	an	DET
admet-796	168	10	alternative	alternative	ADJ
admet-796	168	11	strategy	strategy	NOUN
admet-796	168	12	for	for	ADP
admet-796	168	13	determination	determination	NOUN
admet-796	168	14	of	of	ADP
admet-796	168	15	filgotinib	filgotinib	ADJ
admet-796	168	16	circulatory	circulatory	ADJ
admet-796	168	17	concentration	concentration	NOUN
admet-796	168	18	in	in	ADP
admet-796	168	19	a	a	DET
admet-796	168	20	pharmacokinetic	pharmacokinetic	ADJ
admet-796	168	21	study	study	NOUN
admet-796	168	22	.	.	PUNCT
admet-796	169	1	to	to	ADP
admet-796	169	2	the	the	DET
admet-796	169	3	best	good	ADJ
admet-796	169	4	of	of	ADP
admet-796	169	5	our	our	PRON
admet-796	169	6	knowledge	knowledge	NOUN
admet-796	169	7	,	,	PUNCT
admet-796	169	8	to	to	ADP
admet-796	169	9	date	date	NOUN
admet-796	169	10	there	there	PRON
admet-796	169	11	is	be	VERB
admet-796	169	12	no	no	DET
admet-796	169	13	comparison	comparison	NOUN
admet-796	169	14	between	between	ADP
admet-796	169	15	plasma	plasma	NOUN
admet-796	169	16	and	and	CCONJ
admet-796	169	17	whole	whole	ADJ
admet-796	169	18	blood	blood	NOUN
admet-796	169	19	for	for	ADP
admet-796	169	20	filgotinib	filgotinib	NOUN
admet-796	169	21	.	.	PUNCT
admet-796	170	1	our	our	PRON
admet-796	170	2	study	study	NOUN
admet-796	170	3	demonstrated	demonstrate	VERB
admet-796	170	4	that	that	SCONJ
admet-796	170	5	dbs	dbs	PROPN
admet-796	170	6	is	be	AUX
admet-796	170	7	a	a	DET
admet-796	170	8	promising	promising	ADJ
admet-796	170	9	alternative	alternative	NOUN
admet-796	170	10	to	to	ADP
admet-796	170	11	plasma	plasma	NOUN
admet-796	170	12	sampling	sample	VERB
admet-796	170	13	for	for	ADP
admet-796	170	14	filgotinib	filgotinib	NOUN
admet-796	170	15	in	in	ADP
admet-796	170	16	rheumatoid	rheumatoid	NOUN
admet-796	170	17	arthritis	arthritis	NOUN
admet-796	170	18	patients	patient	NOUN
admet-796	170	19	especially	especially	ADV
admet-796	170	20	with	with	ADP
admet-796	170	21	elderly	elderly	ADJ
admet-796	170	22	patients	patient	NOUN
admet-796	170	23	in	in	ADP
admet-796	170	24	remote	remote	ADJ
admet-796	170	25	or	or	CCONJ
admet-796	170	26	resource	resource	NOUN
admet-796	170	27	-	-	PUNCT
admet-796	170	28	limited	limit	VERB
admet-796	170	29	settings	setting	NOUN
admet-796	170	30	or	or	CCONJ
admet-796	170	31	immobile	immobile	ADJ
admet-796	170	32	patients	patient	NOUN
admet-796	170	33	.	.	PUNCT
admet-796	171	1	conclusions	conclusion	NOUN
admet-796	171	2	in	in	ADP
admet-796	171	3	summary	summary	NOUN
admet-796	171	4	,	,	PUNCT
admet-796	171	5	a	a	DET
admet-796	171	6	simple	simple	ADJ
admet-796	171	7	and	and	CCONJ
admet-796	171	8	rapid	rapid	ADJ
admet-796	171	9	method	method	NOUN
admet-796	171	10	using	use	VERB
admet-796	171	11	lc	lc	PROPN
admet-796	171	12	-	-	PUNCT
admet-796	171	13	ms	ms	PROPN
admet-796	171	14	/	/	SYM
admet-796	171	15	ms	ms	NOUN
admet-796	171	16	for	for	ADP
admet-796	171	17	the	the	DET
admet-796	171	18	determination	determination	NOUN
admet-796	171	19	of	of	ADP
admet-796	171	20	filgotinib	filgotinib	NOUN
admet-796	171	21	in	in	ADP
admet-796	171	22	rat	rat	NOUN
admet-796	171	23	blood	blood	NOUN
admet-796	171	24	using	use	VERB
admet-796	171	25	dbs	dbs	PROPN
admet-796	171	26	cards	card	NOUN
admet-796	171	27	was	be	AUX
admet-796	171	28	developed	develop	VERB
admet-796	171	29	and	and	CCONJ
admet-796	171	30	validated	validate	VERB
admet-796	171	31	as	as	ADP
admet-796	171	32	per	per	ADP
admet-796	171	33	us	we	PRON
admet-796	171	34	fda	fda	PROPN
admet-796	171	35	regulatory	regulatory	ADJ
admet-796	171	36	guideline	guideline	NOUN
admet-796	171	37	.	.	PUNCT
admet-796	172	1	the	the	DET
admet-796	172	2	validated	validate	VERB
admet-796	172	3	method	method	NOUN
admet-796	172	4	suitability	suitability	NOUN
admet-796	172	5	was	be	AUX
admet-796	172	6	shown	show	VERB
admet-796	172	7	in	in	ADP
admet-796	172	8	a	a	DET
admet-796	172	9	rat	rat	NOUN
admet-796	172	10	pharmacokinetic	pharmacokinetic	ADJ
admet-796	172	11	study	study	NOUN
admet-796	172	12	.	.	PUNCT
admet-796	173	1	conflict	conflict	NOUN
admet-796	173	2	of	of	ADP
admet-796	173	3	interest	interest	NOUN
admet-796	173	4	:	:	PUNCT
admet-796	173	5	the	the	DET
admet-796	173	6	authors	author	NOUN
admet-796	173	7	are	be	AUX
admet-796	173	8	scientists	scientist	NOUN
admet-796	173	9	at	at	ADP
admet-796	173	10	jubilant	jubilant	PROPN
admet-796	173	11	biosys	biosys	PROPN
admet-796	173	12	ltd	ltd	PROPN
admet-796	173	13	.	.	PROPN
admet-796	173	14	references	reference	NOUN
admet-796	174	1	[	[	X
admet-796	174	2	1	1	NUM
admet-796	174	3	]	]	X
admet-796	174	4	j.k	j.k	PROPN
admet-796	174	5	.	.	PROPN
admet-796	174	6	buer	buer	PROPN
admet-796	174	7	.	.	PUNCT
admet-796	175	1	a	a	DET
admet-796	175	2	history	history	NOUN
admet-796	175	3	of	of	ADP
admet-796	175	4	the	the	DET
admet-796	175	5	term	term	NOUN
admet-796	175	6	dmard	dmard	NOUN
admet-796	175	7	.	.	PUNCT
admet-796	176	1	inflammopharmacology	inflammopharmacology	NOUN
admet-796	176	2	23	23	NUM
admet-796	176	3	(	(	PUNCT
admet-796	176	4	2015	2015	NUM
admet-796	176	5	)	)	PUNCT
admet-796	176	6	163	163	NUM
admet-796	176	7	-	-	SYM
admet-796	176	8	171	171	NUM
admet-796	176	9	.	.	PUNCT
admet-796	177	1	[	[	X
admet-796	177	2	2	2	NUM
admet-796	177	3	]	]	PUNCT
admet-796	177	4	c.	c.	NOUN
admet-796	177	5	chough	chough	PROPN
admet-796	177	6	,	,	PUNCT
admet-796	177	7	s.	s.	PROPN
admet-796	177	8	lee	lee	PROPN
admet-796	177	9	,	,	PUNCT
admet-796	177	10	m.	m.	PROPN
admet-796	177	11	joung	joung	PROPN
admet-796	177	12	,	,	PUNCT
admet-796	177	13	j.	j.	PROPN
admet-796	177	14	lee	lee	PROPN
admet-796	177	15	,	,	PUNCT
admet-796	177	16	j.h	j.h	PROPN
admet-796	177	17	.	.	PROPN
admet-796	177	18	kim	kim	PROPN
admet-796	177	19	,	,	PUNCT
admet-796	177	20	b.m	b.m	PROPN
admet-796	177	21	.	.	PROPN
admet-796	177	22	kim	kim	PROPN
admet-796	177	23	.	.	PUNCT
admet-796	178	1	design	design	NOUN
admet-796	178	2	,	,	PUNCT
admet-796	178	3	synthesis	synthesis	NOUN
admet-796	178	4	and	and	CCONJ
admet-796	178	5	evaluation	evaluation	NOUN
admet-796	178	6	of	of	ADP
admet-796	178	7	(	(	PUNCT
admet-796	178	8	r)-3-(7(methyl(7h	r)-3-(7(methyl(7h	ADJ
admet-796	178	9	-	-	ADJ
admet-796	178	10	pyrrolo[2,3	pyrrolo[2,3	ADJ
admet-796	178	11	-	-	PUNCT
admet-796	178	12	d]pyrimidin-4	d]pyrimidin-4	PROPN
admet-796	178	13	-	-	PUNCT
admet-796	178	14	yl)amino)-5	yl)amino)-5	PROPN
admet-796	178	15	-	-	PUNCT
admet-796	178	16	aza	aza	NOUN
admet-796	178	17	-	-	PUNCT
admet-796	178	18	spiro[2.4]heptan-5	spiro[2.4]heptan-5	NOUN
admet-796	178	19	-	-	PUNCT
admet-796	178	20	yl)-3	yl)-3	NOUN
admet-796	178	21	-	-	PUNCT
admet-796	178	22	oxopropanenitrile	oxopropanenitrile	NOUN
admet-796	178	23	as	as	ADP
admet-796	178	24	a	a	DET
admet-796	178	25	jak1	jak1	NOUN
admet-796	178	26	-	-	PUNCT
admet-796	178	27	selective	selective	ADJ
admet-796	178	28	inhibitor	inhibitor	NOUN
admet-796	178	29	.	.	PUNCT
admet-796	179	1	medchemcomm	medchemcomm	NOUN
admet-796	179	2	9	9	NUM
admet-796	179	3	(	(	PUNCT
admet-796	179	4	2018	2018	NUM
admet-796	179	5	)	)	PUNCT
admet-796	179	6	477	477	NUM
admet-796	179	7	.	.	PUNCT
admet-796	180	1	[	[	X
admet-796	180	2	3	3	X
admet-796	180	3	]	]	X
admet-796	180	4	j.j	j.j	PROPN
admet-796	180	5	.	.	PROPN
admet-796	180	6	o’shea	o’shea	PROPN
admet-796	180	7	,	,	PUNCT
admet-796	180	8	m.	m.	NOUN
admet-796	180	9	gadina	gadina	PROPN
admet-796	180	10	.	.	PUNCT
admet-796	181	1	(	(	PUNCT
admet-796	181	2	2019	2019	NUM
admet-796	181	3	)	)	PUNCT
admet-796	181	4	.	.	PUNCT
admet-796	182	1	selective	selective	ADJ
admet-796	182	2	janus	janus	PROPN
admet-796	182	3	kinase	kinase	PROPN
admet-796	182	4	inhibitors	inhibitor	NOUN
admet-796	182	5	come	come	VERB
admet-796	182	6	of	of	ADP
admet-796	182	7	age	age	NOUN
admet-796	182	8	.	.	PUNCT
admet-796	183	1	nature	nature	NOUN
admet-796	183	2	reviews	review	VERB
admet-796	183	3	rheumatology	rheumatology	NOUN
admet-796	183	4	15	15	NUM
admet-796	183	5	(	(	PUNCT
admet-796	183	6	2019	2019	NUM
admet-796	183	7	)	)	PUNCT
admet-796	183	8	74	74	NUM
admet-796	183	9	-	-	SYM
admet-796	183	10	75	75	NUM
admet-796	183	11	.	.	PUNCT
admet-796	184	1	[	[	X
admet-796	184	2	4	4	X
admet-796	184	3	]	]	PUNCT
admet-796	184	4	k.	k.	PROPN
admet-796	184	5	yamaoka	yamaoka	PROPN
admet-796	184	6	.	.	PUNCT
admet-796	185	1	janus	janus	PROPN
admet-796	185	2	kinase	kinase	PROPN
admet-796	185	3	inhibitors	inhibitor	NOUN
admet-796	185	4	for	for	ADP
admet-796	185	5	rheumatoid	rheumatoid	NOUN
admet-796	185	6	arthritis	arthritis	NOUN
admet-796	185	7	.	.	PUNCT
admet-796	186	1	current	current	ADJ
admet-796	186	2	opinion	opinion	NOUN
admet-796	186	3	in	in	ADP
admet-796	186	4	chemical	chemical	ADJ
admet-796	186	5	biology	biology	NOUN
admet-796	186	6	32	32	NUM
admet-796	186	7	(	(	PUNCT
admet-796	186	8	2016	2016	NUM
admet-796	186	9	)	)	PUNCT
admet-796	186	10	29	29	NUM
admet-796	186	11	-	-	SYM
admet-796	186	12	33	33	NUM
admet-796	186	13	.	.	PUNCT
admet-796	187	1	http://dx.doi.org/10.5599/admet.796	http://dx.doi.org/10.5599/admet.796	PROPN
admet-796	187	2	r.	r.	PROPN
admet-796	187	3	mullangi	mullangi	PROPN
admet-796	187	4	et	et	PROPN
admet-796	187	5	al	al	PROPN
admet-796	187	6	.	.	PROPN
admet-796	187	7	admet	admet	PROPN
admet-796	187	8	&	&	CCONJ
admet-796	187	9	dmpk	dmpk	PROPN
admet-796	187	10	8(2	8(2	NUM
admet-796	187	11	)	)	PUNCT
admet-796	187	12	(	(	PUNCT
admet-796	187	13	2020	2020	NUM
admet-796	187	14	)	)	PUNCT
admet-796	187	15	139	139	NUM
admet-796	187	16	-	-	SYM
admet-796	187	17	148	148	NUM
admet-796	187	18	148	148	NUM
admet-796	187	19	[	[	X
admet-796	187	20	5	5	NUM
admet-796	187	21	]	]	PUNCT
admet-796	187	22	l.	l.	PROPN
admet-796	187	23	van	van	PROPN
admet-796	187	24	rompaey	rompaey	PROPN
admet-796	187	25	,	,	PUNCT
admet-796	187	26	r.	r.	PROPN
admet-796	187	27	galien	galien	PROPN
admet-796	187	28	,	,	PUNCT
admet-796	187	29	e.	e.	PROPN
admet-796	187	30	m.	m.	PROPN
admet-796	187	31	van	van	PROPN
admet-796	187	32	der	der	PROPN
admet-796	187	33	aar	aar	NOUN
admet-796	187	34	,	,	PUNCT
admet-796	187	35	p.	p.	PROPN
admet-796	187	36	clement	clement	PROPN
admet-796	187	37	-	-	PUNCT
admet-796	187	38	lacroix	lacroix	PROPN
admet-796	187	39	,	,	PUNCT
admet-796	187	40	l.	l.	PROPN
admet-796	187	41	nelles	nelles	PROPN
admet-796	187	42	,	,	PUNCT
admet-796	187	43	b.	b.	PROPN
admet-796	187	44	smets	smet	NOUN
admet-796	187	45	,	,	PUNCT
admet-796	187	46	l.	l.	PROPN
admet-796	187	47	lepescheux	lepescheux	PROPN
admet-796	187	48	,	,	PUNCT
admet-796	187	49	t.	t.	PROPN
admet-796	187	50	christophe	christophe	PROPN
admet-796	187	51	,	,	PUNCT
admet-796	187	52	k.	k.	PROPN
admet-796	187	53	conrath	conrath	PROPN
admet-796	187	54	,	,	PUNCT
admet-796	187	55	n.	n.	PROPN
admet-796	187	56	vandeghinste	vandeghinste	PROPN
admet-796	187	57	,	,	PUNCT
admet-796	187	58	b.	b.	PROPN
admet-796	187	59	vayssiere	vayssiere	PROPN
admet-796	187	60	,	,	PUNCT
admet-796	187	61	s.	s.	PROPN
admet-796	187	62	de	de	PROPN
admet-796	187	63	vos	vos	PROPN
admet-796	187	64	,	,	PUNCT
admet-796	187	65	s.	s.	PROPN
admet-796	187	66	fletcher	fletcher	PROPN
admet-796	187	67	,	,	PUNCT
admet-796	187	68	r.	r.	PROPN
admet-796	187	69	brys	brys	PROPN
admet-796	187	70	,	,	PUNCT
admet-796	187	71	g.	g.	PROPN
admet-796	187	72	van't	van't	PROPN
admet-796	187	73	klooster	klooster	PROPN
admet-796	187	74	,	,	PUNCT
admet-796	187	75	j.	j.	PROPN
admet-796	187	76	h.	h.	PROPN
admet-796	187	77	m.	m.	PROPN
admet-796	187	78	feyen	feyen	PROPN
admet-796	187	79	and	and	CCONJ
admet-796	187	80	c.menet	c.menet	NOUN
admet-796	187	81	.	.	PUNCT
admet-796	188	1	preclinical	preclinical	ADJ
admet-796	188	2	characterization	characterization	NOUN
admet-796	188	3	of	of	ADP
admet-796	188	4	glpg0634	glpg0634	PROPN
admet-796	188	5	,	,	PUNCT
admet-796	188	6	a	a	DET
admet-796	188	7	selective	selective	ADJ
admet-796	188	8	inhibitor	inhibitor	NOUN
admet-796	188	9	of	of	ADP
admet-796	188	10	jak1	jak1	PROPN
admet-796	188	11	,	,	PUNCT
admet-796	188	12	for	for	ADP
admet-796	188	13	the	the	DET
admet-796	188	14	treatment	treatment	NOUN
admet-796	188	15	of	of	ADP
admet-796	188	16	inflammatory	inflammatory	ADJ
admet-796	188	17	diseases	disease	NOUN
admet-796	188	18	.	.	PUNCT
admet-796	189	1	journal	journal	NOUN
admet-796	189	2	of	of	ADP
admet-796	189	3	immunology	immunology	NOUN
admet-796	189	4	191	191	NUM
admet-796	189	5	(	(	PUNCT
admet-796	189	6	2013	2013	NUM
admet-796	189	7	)	)	PUNCT
admet-796	189	8	3568	3568	NUM
admet-796	189	9	-	-	SYM
admet-796	189	10	3577	3577	NUM
admet-796	189	11	.	.	PUNCT
admet-796	190	1	[	[	X
admet-796	190	2	6	6	NUM
admet-796	190	3	]	]	PUNCT
admet-796	190	4	m.	m.	NOUN
admet-796	190	5	genovese	genovese	NOUN
admet-796	190	6	,	,	PUNCT
admet-796	190	7	r.	r.	PROPN
admet-796	190	8	westhovens	westhovens	PROPN
admet-796	190	9	,	,	PUNCT
admet-796	190	10	l.	l.	PROPN
admet-796	190	11	meuleners	meuleners	PROPN
admet-796	190	12	,	,	PUNCT
admet-796	190	13	a.	a.	PROPN
admet-796	190	14	van	van	PROPN
admet-796	190	15	der	der	PROPN
admet-796	190	16	aa	aa	PROPN
admet-796	190	17	,	,	PUNCT
admet-796	190	18	p.	p.	PROPN
admet-796	190	19	harrison	harrison	PROPN
admet-796	190	20	,	,	PUNCT
admet-796	190	21	c.	c.	PROPN
admet-796	190	22	tasset	tasset	PROPN
admet-796	190	23	,	,	PUNCT
admet-796	190	24	a.	a.	PROPN
admet-796	190	25	kavanaugh	kavanaugh	PROPN
admet-796	190	26	.	.	PUNCT
admet-796	191	1	effect	effect	NOUN
admet-796	191	2	of	of	ADP
admet-796	191	3	filgotinib	filgotinib	NOUN
admet-796	191	4	,	,	PUNCT
admet-796	191	5	a	a	DET
admet-796	191	6	selective	selective	ADJ
admet-796	191	7	jak	jak	PROPN
admet-796	191	8	1	1	NUM
admet-796	191	9	inhibitor	inhibitor	NOUN
admet-796	191	10	,	,	PUNCT
admet-796	191	11	with	with	ADP
admet-796	191	12	and	and	CCONJ
admet-796	191	13	without	without	ADP
admet-796	191	14	methotrexate	methotrexate	NOUN
admet-796	191	15	in	in	ADP
admet-796	191	16	patients	patient	NOUN
admet-796	191	17	with	with	ADP
admet-796	191	18	rheumatoid	rheumatoid	NOUN
admet-796	191	19	arthritis	arthritis	NOUN
admet-796	191	20	:	:	PUNCT
admet-796	191	21	patient	patient	NOUN
admet-796	191	22	-	-	PUNCT
admet-796	191	23	reported	report	VERB
admet-796	191	24	outcomes	outcome	NOUN
admet-796	191	25	.	.	PUNCT
admet-796	192	1	arthritis	arthritis	NOUN
admet-796	192	2	research	research	PROPN
admet-796	192	3	&	&	CCONJ
admet-796	192	4	therapy	therapy	PROPN
admet-796	192	5	20	20	NUM
admet-796	192	6	(	(	PUNCT
admet-796	192	7	2018	2018	NUM
admet-796	192	8	)	)	PUNCT
admet-796	192	9	57	57	NUM
admet-796	192	10	.	.	PUNCT
admet-796	193	1	[	[	X
admet-796	193	2	7	7	NUM
admet-796	193	3	]	]	X
admet-796	193	4	pharma	pharma	PROPN
admet-796	193	5	japan	japan	PROPN
admet-796	193	6	(	(	PUNCT
admet-796	193	7	2019	2019	NUM
admet-796	193	8	)	)	PUNCT
admet-796	193	9	.	.	PUNCT
admet-796	194	1	https://pj.jiho.jp/article/240785	https://pj.jiho.jp/article/240785	PROPN
admet-796	194	2	.	.	PUNCT
admet-796	195	1	[	[	X
admet-796	195	2	8	8	NUM
admet-796	195	3	]	]	X
admet-796	195	4	https://www.gilead.com/news-and-press/press-room/press-releases	https://www.gilead.com/news-and-press/press-room/press-release	NOUN
admet-796	195	5	(	(	PUNCT
admet-796	195	6	accessed	access	VERB
admet-796	195	7	may	may	PROPN
admet-796	195	8	01	01	NUM
admet-796	195	9	,	,	PUNCT
admet-796	195	10	2020	2020	NUM
admet-796	195	11	.	.	PUNCT
admet-796	195	12	)	)	PUNCT
admet-796	196	1	[	[	X
admet-796	196	2	9	9	NUM
admet-796	196	3	]	]	PUNCT
admet-796	196	4	f.	f.	NOUN
admet-796	196	5	namour	namour	PROPN
admet-796	196	6	,	,	PUNCT
admet-796	196	7	p.m.	p.m.	NOUN
admet-796	196	8	diderichsen	diderichsen	PROPN
admet-796	196	9	,	,	PUNCT
admet-796	196	10	e.	e.	PROPN
admet-796	196	11	cox	cox	PROPN
admet-796	196	12	,	,	PUNCT
admet-796	196	13	b.	b.	PROPN
admet-796	196	14	vayssie`re	vayssie`re	PROPN
admet-796	196	15	,	,	PUNCT
admet-796	196	16	a.v	a.v	PROPN
admet-796	196	17	.	.	PROPN
admet-796	196	18	aa	aa	PROPN
admet-796	196	19	,	,	PUNCT
admet-796	196	20	c.	c.	PROPN
admet-796	196	21	tasset	tasset	PROPN
admet-796	196	22	,	,	PUNCT
admet-796	196	23	v.g	v.g	PROPN
admet-796	196	24	.	.	PROPN
admet-796	196	25	klooster	klooster	PROPN
admet-796	196	26	.	.	PUNCT
admet-796	197	1	pharmacokinetics	pharmacokinetic	NOUN
admet-796	197	2	and	and	CCONJ
admet-796	197	3	pharmacokinetic	pharmacokinetic	ADJ
admet-796	197	4	/	/	SYM
admet-796	197	5	pharmacodynamic	pharmacodynamic	ADJ
admet-796	197	6	modeling	modeling	NOUN
admet-796	197	7	of	of	ADP
admet-796	197	8	filgotinib	filgotinib	NOUN
admet-796	197	9	(	(	PUNCT
admet-796	197	10	glpg0634	glpg0634	PROPN
admet-796	197	11	)	)	PUNCT
admet-796	197	12	,	,	PUNCT
admet-796	197	13	a	a	DET
admet-796	197	14	selective	selective	ADJ
admet-796	197	15	jak1	jak1	NOUN
admet-796	197	16	inhibitor	inhibitor	NOUN
admet-796	197	17	,	,	PUNCT
admet-796	197	18	in	in	ADP
admet-796	197	19	support	support	NOUN
admet-796	197	20	of	of	ADP
admet-796	197	21	phase	phase	NOUN
admet-796	197	22	iib	iib	PROPN
admet-796	197	23	dose	dose	PROPN
admet-796	197	24	selection	selection	NOUN
admet-796	197	25	.	.	PUNCT
admet-796	198	1	clinical	clinical	ADJ
admet-796	198	2	pharmacokinetics	pharmacokinetic	NOUN
admet-796	198	3	54	54	NUM
admet-796	198	4	(	(	PUNCT
admet-796	198	5	2015	2015	NUM
admet-796	198	6	)	)	PUNCT
admet-796	198	7	859	859	NUM
admet-796	198	8	-	-	SYM
admet-796	198	9	874	874	NUM
admet-796	198	10	.	.	PUNCT
admet-796	199	1	[	[	X
admet-796	199	2	10	10	NUM
admet-796	199	3	]	]	PUNCT
admet-796	199	4	a.	a.	NOUN
admet-796	199	5	dixit	dixit	PROPN
admet-796	199	6	,	,	PUNCT
admet-796	199	7	v.	v.	PROPN
admet-796	199	8	kiran	kiran	PROPN
admet-796	199	9	,	,	PUNCT
admet-796	199	10	b.b	b.b	PROPN
admet-796	199	11	.	.	PROPN
admet-796	199	12	gabani	gabani	PROPN
admet-796	199	13	,	,	PUNCT
admet-796	199	14	z.	z.	PROPN
admet-796	199	15	mohd	mohd	PROPN
admet-796	199	16	,	,	PUNCT
admet-796	199	17	r.r	r.r	PROPN
admet-796	199	18	.	.	PROPN
admet-796	199	19	trivedi	trivedi	PROPN
admet-796	199	20	,	,	PUNCT
admet-796	199	21	r.	r.	PROPN
admet-796	199	22	mullangi	mullangi	PROPN
admet-796	199	23	.	.	PUNCT
admet-796	200	1	validated	validate	VERB
admet-796	200	2	lc	lc	PROPN
admet-796	200	3	-	-	PUNCT
admet-796	200	4	ms	ms	PROPN
admet-796	200	5	/	/	SYM
admet-796	200	6	ms	ms	PROPN
admet-796	200	7	method	method	NOUN
admet-796	200	8	for	for	ADP
admet-796	200	9	quantitation	quantitation	NOUN
admet-796	200	10	of	of	ADP
admet-796	200	11	a	a	DET
admet-796	200	12	selective	selective	ADJ
admet-796	200	13	jak1	jak1	PROPN
admet-796	200	14	inhibitor	inhibitor	NOUN
admet-796	200	15	,	,	PUNCT
admet-796	200	16	filgotinib	filgotinib	VERB
admet-796	200	17	in	in	ADP
admet-796	200	18	rat	rat	NOUN
admet-796	200	19	plasma	plasma	NOUN
admet-796	200	20	and	and	CCONJ
admet-796	200	21	its	its	PRON
admet-796	200	22	application	application	NOUN
admet-796	200	23	to	to	ADP
admet-796	200	24	a	a	DET
admet-796	200	25	pharmacokinetics	pharmacokinetic	NOUN
admet-796	200	26	study	study	NOUN
admet-796	200	27	in	in	ADP
admet-796	200	28	rats	rat	NOUN
admet-796	200	29	.	.	PUNCT
admet-796	201	1	biomedical	biomedical	ADJ
admet-796	201	2	chromatography	chromatography	NOUN
admet-796	201	3	(	(	PUNCT
admet-796	201	4	2020	2020	NUM
admet-796	201	5	)	)	PUNCT
admet-796	201	6	accepted	accept	VERB
admet-796	201	7	.	.	PUNCT
admet-796	202	1	[	[	X
admet-796	202	2	11	11	NUM
admet-796	202	3	]	]	PUNCT
admet-796	202	4	sulochana	sulochana	NOUN
admet-796	202	5	sp	sp	PROPN
admet-796	202	6	,	,	PUNCT
admet-796	202	7	daram	daram	PROPN
admet-796	202	8	p	p	PROPN
admet-796	202	9	,	,	PUNCT
admet-796	202	10	srinivas	srinivas	PROPN
admet-796	202	11	nr	nr	PROPN
admet-796	202	12	,	,	PUNCT
admet-796	202	13	mullangi	mullangi	VERB
admet-796	202	14	r.	r.	PROPN
admet-796	202	15	review	review	PROPN
admet-796	202	16	of	of	ADP
admet-796	202	17	dbs	dbs	PROPN
admet-796	202	18	methods	method	NOUN
admet-796	202	19	as	as	ADP
admet-796	202	20	a	a	DET
admet-796	202	21	quantitative	quantitative	ADJ
admet-796	202	22	tool	tool	NOUN
admet-796	202	23	for	for	ADP
admet-796	202	24	anticancer	anticancer	NOUN
admet-796	202	25	drugs	drug	NOUN
admet-796	202	26	.	.	PUNCT
admet-796	203	1	biomedical	biomedical	ADJ
admet-796	203	2	chromatography	chromatography	NOUN
admet-796	203	3	33	33	NUM
admet-796	203	4	(	(	PUNCT
admet-796	203	5	2019	2019	NUM
admet-796	203	6	)	)	PUNCT
admet-796	203	7	e4445	e4445	NOUN
admet-796	203	8	.	.	PUNCT
admet-796	204	1	[	[	X
admet-796	204	2	12	12	NUM
admet-796	204	3	]	]	X
admet-796	204	4	k.i	k.i	PROPN
admet-796	204	5	.	.	PUNCT
admet-796	204	6	foerster	foerster	PROPN
admet-796	204	7	,	,	PUNCT
admet-796	204	8	a.	a.	PROPN
admet-796	204	9	huppertz	huppertz	PROPN
admet-796	204	10	,	,	PUNCT
admet-796	204	11	a.d	a.d	PROPN
admet-796	204	12	.	.	PROPN
admet-796	204	13	meid	meid	PROPN
admet-796	204	14	,	,	PUNCT
admet-796	204	15	o.j	o.j	PROPN
admet-796	204	16	.	.	PROPN
admet-796	204	17	müller	müller	PROPN
admet-796	204	18	,	,	PUNCT
admet-796	204	19	t.	t.	PROPN
admet-796	204	20	rizos	rizos	PROPN
admet-796	204	21	,	,	PUNCT
admet-796	204	22	l.	l.	PROPN
admet-796	204	23	tilemann	tilemann	PROPN
admet-796	204	24	,	,	PUNCT
admet-796	204	25	w.e	w.e	PROPN
admet-796	204	26	.	.	PROPN
admet-796	204	27	haefeli	haefeli	PROPN
admet-796	204	28	,	,	PUNCT
admet-796	204	29	j.	j.	PROPN
admet-796	204	30	burhenne	burhenne	PROPN
admet-796	204	31	.	.	PUNCT
admet-796	205	1	dried	dry	VERB
admet-796	205	2	blood	blood	NOUN
admet-796	205	3	spot	spot	NOUN
admet-796	205	4	technique	technique	NOUN
admet-796	205	5	to	to	PART
admet-796	205	6	monitor	monitor	VERB
admet-796	205	7	direct	direct	ADJ
admet-796	205	8	oral	oral	ADJ
admet-796	205	9	anticoagulants	anticoagulant	NOUN
admet-796	205	10	:	:	PUNCT
admet-796	205	11	clinical	clinical	ADJ
admet-796	205	12	validation	validation	NOUN
admet-796	205	13	of	of	ADP
admet-796	205	14	an	an	DET
admet-796	205	15	uplc	uplc	ADJ
admet-796	205	16	/	/	SYM
admet-796	205	17	ms	ms	PROPN
admet-796	205	18	/	/	SYM
admet-796	205	19	ms	ms	PROPN
admet-796	205	20	based	base	VERB
admet-796	205	21	assay	assay	PROPN
admet-796	205	22	.	.	PUNCT
admet-796	206	1	analytical	analytical	ADJ
admet-796	206	2	chemistry	chemistry	NOUN
admet-796	206	3	90	90	NUM
admet-796	206	4	(	(	PUNCT
admet-796	206	5	2018	2018	NUM
admet-796	206	6	)	)	PUNCT
admet-796	206	7	337	337	NUM
admet-796	206	8	-	-	SYM
admet-796	206	9	341	341	NUM
admet-796	206	10	.	.	PUNCT
admet-796	207	1	[	[	X
admet-796	207	2	13	13	NUM
admet-796	207	3	]	]	X
admet-796	207	4	h.m	h.m	PROPN
admet-796	207	5	.	.	PROPN
admet-796	207	6	kim	kim	PROPN
admet-796	207	7	,	,	PUNCT
admet-796	207	8	j.	j.	PROPN
admet-796	207	9	park	park	PROPN
admet-796	207	10	,	,	PUNCT
admet-796	207	11	n.p	n.p	PROPN
admet-796	207	12	.	.	PROPN
admet-796	207	13	long	long	PROPN
admet-796	207	14	,	,	PUNCT
admet-796	207	15	d.d	d.d	PROPN
admet-796	207	16	.	.	PROPN
admet-796	207	17	kim	kim	PROPN
admet-796	207	18	,	,	PUNCT
admet-796	207	19	s.w	s.w	PROPN
admet-796	207	20	.	.	PROPN
admet-796	207	21	kwon	kwon	PROPN
admet-796	207	22	.	.	PUNCT
admet-796	208	1	simultaneous	simultaneous	ADJ
admet-796	208	2	determination	determination	NOUN
admet-796	208	3	of	of	ADP
admet-796	208	4	cardiovascular	cardiovascular	ADJ
admet-796	208	5	drugs	drug	NOUN
admet-796	208	6	in	in	ADP
admet-796	208	7	dried	dry	VERB
admet-796	208	8	blood	blood	NOUN
admet-796	208	9	spot	spot	NOUN
admet-796	208	10	by	by	ADP
admet-796	208	11	liquid	liquid	ADJ
admet-796	208	12	chromatography	chromatography	NOUN
admet-796	208	13	-	-	PUNCT
admet-796	208	14	tandem	tandem	NOUN
admet-796	208	15	mass	mass	PROPN
admet-796	208	16	spectrometry	spectrometry	NOUN
admet-796	208	17	.	.	PUNCT
admet-796	209	1	journal	journal	PROPN
admet-796	209	2	of	of	ADP
admet-796	209	3	food	food	NOUN
admet-796	209	4	and	and	CCONJ
admet-796	209	5	drug	drug	NOUN
admet-796	209	6	analysis	analysis	NOUN
admet-796	209	7	27	27	NUM
admet-796	209	8	(	(	PUNCT
admet-796	209	9	2019	2019	NUM
admet-796	209	10	)	)	PUNCT
admet-796	209	11	906	906	NUM
admet-796	209	12	-	-	SYM
admet-796	209	13	914	914	NUM
admet-796	209	14	.	.	PUNCT
admet-796	210	1	[	[	X
admet-796	210	2	14	14	NUM
admet-796	210	3	]	]	X
admet-796	210	4	j.	j.	PROPN
admet-796	210	5	gallaya	gallaya	PROPN
admet-796	210	6	,	,	PUNCT
admet-796	210	7	s.	s.	PROPN
admet-796	210	8	prod’hom	prod’hom	PROPN
admet-796	210	9	,	,	PUNCT
admet-796	210	10	t.	t.	NOUN
admet-796	210	11	mercierc	mercierc	NOUN
admet-796	210	12	,	,	PUNCT
admet-796	210	13	c.	c.	PROPN
admet-796	210	14	bardinet	bardinet	PROPN
admet-796	210	15	,	,	PUNCT
admet-796	210	16	d.	d.	PROPN
admet-796	210	17	spaggiari	spaggiari	PROPN
admet-796	210	18	,	,	PUNCT
admet-796	210	19	e.	e.	PROPN
admet-796	210	20	pothina	pothina	PROPN
admet-796	210	21	,	,	PUNCT
admet-796	210	22	t.	t.	PROPN
admet-796	210	23	buclinc	buclinc	PROPN
admet-796	210	24	,	,	PUNCT
admet-796	210	25	b.	b.	PROPN
admet-796	210	26	gentona	gentona	PROPN
admet-796	210	27	,	,	PUNCT
admet-796	210	28	l.a	l.a	PROPN
admet-796	210	29	.	.	PROPN
admet-796	210	30	decosterd	decosterd	PROPN
admet-796	210	31	.	.	PUNCT
admet-796	211	1	lc	lc	PROPN
admet-796	211	2	-	-	PUNCT
admet-796	211	3	ms	ms	PROPN
admet-796	211	4	/	/	SYM
admet-796	211	5	ms	ms	PROPN
admet-796	211	6	method	method	NOUN
admet-796	211	7	for	for	ADP
admet-796	211	8	the	the	DET
admet-796	211	9	simultaneous	simultaneous	ADJ
admet-796	211	10	analysis	analysis	NOUN
admet-796	211	11	of	of	ADP
admet-796	211	12	seven	seven	NUM
admet-796	211	13	antimalarials	antimalarial	NOUN
admet-796	211	14	and	and	CCONJ
admet-796	211	15	two	two	NUM
admet-796	211	16	active	active	ADJ
admet-796	211	17	metabolites	metabolite	NOUN
admet-796	211	18	in	in	ADP
admet-796	211	19	dried	dry	VERB
admet-796	211	20	blood	blood	NOUN
admet-796	211	21	spots	spot	NOUN
admet-796	211	22	for	for	ADP
admet-796	211	23	applications	application	NOUN
admet-796	211	24	in	in	ADP
admet-796	211	25	field	field	NOUN
admet-796	211	26	trials	trial	NOUN
admet-796	211	27	:	:	PUNCT
admet-796	211	28	analytical	analytical	ADJ
admet-796	211	29	and	and	CCONJ
admet-796	211	30	clinical	clinical	ADJ
admet-796	211	31	validation	validation	NOUN
admet-796	211	32	.	.	PUNCT
admet-796	212	1	journal	journal	NOUN
admet-796	212	2	of	of	ADP
admet-796	212	3	pharmaceutical	pharmaceutical	NOUN
admet-796	212	4	and	and	CCONJ
admet-796	212	5	biomedical	biomedical	ADJ
admet-796	212	6	analysis	analysis	NOUN
admet-796	212	7	154	154	NUM
admet-796	212	8	(	(	PUNCT
admet-796	212	9	2018	2018	NUM
admet-796	212	10	)	)	PUNCT
admet-796	212	11	263	263	NUM
admet-796	212	12	-	-	SYM
admet-796	212	13	277	277	NUM
admet-796	212	14	.	.	PUNCT
admet-796	213	1	[	[	X
admet-796	213	2	15	15	NUM
admet-796	213	3	]	]	X
admet-796	213	4	m.	m.	NOUN
admet-796	213	5	moretti	moretti	PROPN
admet-796	213	6	,	,	PUNCT
admet-796	213	7	f.	f.	PROPN
admet-796	213	8	freni	freni	PROPN
admet-796	213	9	,	,	PUNCT
admet-796	213	10	b.	b.	PROPN
admet-796	213	11	valentini	valentini	PROPN
admet-796	213	12	,	,	PUNCT
admet-796	213	13	c.	c.	PROPN
admet-796	213	14	vignali	vignali	PROPN
admet-796	213	15	,	,	PUNCT
admet-796	213	16	a.	a.	PROPN
admet-796	213	17	groppi	groppi	PROPN
admet-796	213	18	,	,	PUNCT
admet-796	213	19	s.d	s.d	PROPN
admet-796	213	20	visonà	visonà	NOUN
admet-796	213	21	,	,	PUNCT
admet-796	213	22	a.m.m	a.m.m	NOUN
admet-796	213	23	.	.	PUNCT
admet-796	213	24	osculati	osculati	PROPN
admet-796	213	25	,	,	PUNCT
admet-796	213	26	l.	l.	PROPN
admet-796	213	27	morini	morini	PROPN
admet-796	213	28	.	.	PROPN
admet-796	213	29	determination	determination	NOUN
admet-796	213	30	of	of	ADP
admet-796	213	31	antidepressants	antidepressant	NOUN
admet-796	213	32	and	and	CCONJ
admet-796	213	33	antipsychotics	antipsychotic	NOUN
admet-796	213	34	in	in	ADP
admet-796	213	35	dried	dry	VERB
admet-796	213	36	blood	blood	NOUN
admet-796	213	37	spots	spot	NOUN
admet-796	213	38	(	(	PUNCT
admet-796	213	39	dbss	dbss	NOUN
admet-796	213	40	)	)	PUNCT
admet-796	213	41	collected	collect	VERB
admet-796	213	42	from	from	ADP
admet-796	213	43	post	post	ADJ
admet-796	213	44	-	-	ADJ
admet-796	213	45	mortem	mortem	ADJ
admet-796	213	46	samples	sample	NOUN
admet-796	213	47	and	and	CCONJ
admet-796	213	48	evaluation	evaluation	NOUN
admet-796	213	49	of	of	ADP
admet-796	213	50	the	the	DET
admet-796	213	51	stability	stability	NOUN
admet-796	213	52	over	over	ADP
admet-796	213	53	a	a	DET
admet-796	213	54	three	three	NUM
admet-796	213	55	-	-	PUNCT
admet-796	213	56	month	month	NOUN
admet-796	213	57	period	period	NOUN
admet-796	213	58	.	.	PUNCT
admet-796	214	1	molecules	molecule	NOUN
admet-796	214	2	24	24	NUM
admet-796	214	3	(	(	PUNCT
admet-796	214	4	2019	2019	NUM
admet-796	214	5	)	)	PUNCT
admet-796	214	6	pii	pii	PROPN
admet-796	214	7	:	:	PUNCT
admet-796	214	8	e3636	e3636	NOUN
admet-796	214	9	.	.	PUNCT
admet-796	215	1	[	[	X
admet-796	215	2	16	16	NUM
admet-796	215	3	]	]	PUNCT
admet-796	215	4	s.	s.	PROPN
admet-796	215	5	velghe	velghe	PROPN
admet-796	215	6	,	,	PUNCT
admet-796	215	7	s.	s.	PROPN
admet-796	215	8	deprez	deprez	PROPN
admet-796	215	9	,	,	PUNCT
admet-796	215	10	c.p	c.p	PROPN
admet-796	215	11	.	.	PROPN
admet-796	215	12	stove	stove	PROPN
admet-796	215	13	.	.	PUNCT
admet-796	216	1	fully	fully	ADV
admet-796	216	2	automated	automate	VERB
admet-796	216	3	therapeutic	therapeutic	ADJ
admet-796	216	4	drug	drug	NOUN
admet-796	216	5	monitoring	monitoring	NOUN
admet-796	216	6	of	of	ADP
admet-796	216	7	anti	anti	ADJ
admet-796	216	8	-	-	ADJ
admet-796	216	9	epileptic	epileptic	ADJ
admet-796	216	10	drugs	drug	NOUN
admet-796	216	11	making	make	VERB
admet-796	216	12	use	use	NOUN
admet-796	216	13	of	of	ADP
admet-796	216	14	dried	dry	VERB
admet-796	216	15	blood	blood	NOUN
admet-796	216	16	spots	spot	NOUN
admet-796	216	17	.	.	PUNCT
admet-796	217	1	journal	journal	NOUN
admet-796	217	2	of	of	ADP
admet-796	217	3	chromatography	chromatography	NOUN
admet-796	217	4	a	a	DET
admet-796	217	5	1601	1601	NUM
admet-796	217	6	(	(	PUNCT
admet-796	217	7	2019	2019	NUM
admet-796	217	8	)	)	PUNCT
admet-796	217	9	95	95	NUM
admet-796	217	10	-	-	SYM
admet-796	217	11	103	103	NUM
admet-796	217	12	.	.	PUNCT
admet-796	218	1	[	[	X
admet-796	218	2	17	17	NUM
admet-796	218	3	]	]	SYM
admet-796	218	4	dhhs	dhhs	PROPN
admet-796	218	5	,	,	PUNCT
admet-796	218	6	fda	fda	PROPN
admet-796	218	7	,	,	PUNCT
admet-796	218	8	cder	cder	NOUN
admet-796	218	9	,	,	PUNCT
admet-796	218	10	&	&	CCONJ
admet-796	218	11	cvm	cvm	PROPN
admet-796	218	12	(	(	PUNCT
admet-796	218	13	2018	2018	NUM
admet-796	218	14	)	)	PUNCT
admet-796	218	15	.	.	PUNCT
admet-796	219	1	guidance	guidance	NOUN
admet-796	219	2	for	for	ADP
admet-796	219	3	industry	industry	NOUN
admet-796	219	4	:	:	PUNCT
admet-796	219	5	bioanalytical	bioanalytical	ADJ
admet-796	219	6	method	method	NOUN
admet-796	219	7	validation	validation	NOUN
admet-796	219	8	.	.	PUNCT
admet-796	220	1	rockville	rockville	PROPN
admet-796	220	2	,	,	PUNCT
admet-796	220	3	md	md	PROPN
admet-796	220	4	:	:	PUNCT
admet-796	220	5	us	us	PROPN
admet-796	220	6	department	department	PROPN
admet-796	220	7	of	of	ADP
admet-796	220	8	health	health	PROPN
admet-796	220	9	and	and	CCONJ
admet-796	220	10	human	human	ADJ
admet-796	220	11	services	service	NOUN
admet-796	220	12	,	,	PUNCT
admet-796	220	13	food	food	NOUN
admet-796	220	14	and	and	CCONJ
admet-796	220	15	drug	drug	NOUN
admet-796	220	16	administration	administration	NOUN
admet-796	220	17	,	,	PUNCT
admet-796	220	18	center	center	NOUN
admet-796	220	19	for	for	ADP
admet-796	220	20	drug	drug	NOUN
admet-796	220	21	evaluation	evaluation	NOUN
admet-796	220	22	and	and	CCONJ
admet-796	220	23	research	research	NOUN
admet-796	220	24	and	and	CCONJ
admet-796	220	25	center	center	NOUN
admet-796	220	26	for	for	ADP
admet-796	220	27	veterinary	veterinary	ADJ
admet-796	220	28	medicine	medicine	NOUN
admet-796	220	29	.	.	PUNCT
admet-796	221	1	[	[	X
admet-796	221	2	18	18	NUM
admet-796	221	3	]	]	PUNCT
admet-796	221	4	m.	m.	NOUN
admet-796	221	5	o’mara	o’mara	PROPN
admet-796	221	6	,	,	PUNCT
admet-796	221	7	b.	b.	PROPN
admet-796	221	8	hudson	hudson	PROPN
admet-796	221	9	-	-	PUNCT
admet-796	221	10	curtis	curtis	PROPN
admet-796	221	11	,	,	PUNCT
admet-796	221	12	k.	k.	PROPN
admet-796	221	13	olson	olson	PROPN
admet-796	221	14	,	,	PUNCT
admet-796	221	15	y.	y.	PROPN
admet-796	221	16	yueh	yueh	PROPN
admet-796	221	17	,	,	PUNCT
admet-796	221	18	j.	j.	PROPN
admet-796	221	19	dunn	dunn	PROPN
admet-796	221	20	,	,	PUNCT
admet-796	221	21	n.	n.	PROPN
admet-796	221	22	spooner	spooner	PROPN
admet-796	221	23	.	.	PUNCT
admet-796	222	1	the	the	DET
admet-796	222	2	effect	effect	NOUN
admet-796	222	3	of	of	ADP
admet-796	222	4	hematocrit	hematocrit	NOUN
admet-796	222	5	and	and	CCONJ
admet-796	222	6	punch	punch	VERB
admet-796	222	7	location	location	NOUN
admet-796	222	8	on	on	ADP
admet-796	222	9	assay	assay	NOUN
admet-796	222	10	bias	bias	NOUN
admet-796	222	11	during	during	ADP
admet-796	222	12	quantitative	quantitative	ADJ
admet-796	222	13	bioanalysis	bioanalysis	NOUN
admet-796	222	14	of	of	ADP
admet-796	222	15	dried	dry	VERB
admet-796	222	16	blood	blood	NOUN
admet-796	222	17	spot	spot	NOUN
admet-796	222	18	samples	sample	NOUN
admet-796	222	19	.	.	PUNCT
admet-796	223	1	bioanalysis	bioanalysis	NOUN
admet-796	223	2	20	20	NUM
admet-796	223	3	(	(	PUNCT
admet-796	223	4	2011	2011	NUM
admet-796	223	5	)	)	PUNCT
admet-796	223	6	2335	2335	NUM
admet-796	223	7	-	-	SYM
admet-796	223	8	2347	2347	NUM
admet-796	223	9	.	.	PUNCT
admet-796	224	1	[	[	X
admet-796	224	2	19	19	NUM
admet-796	224	3	]	]	X
admet-796	224	4	m.e	m.e	PROPN
admet-796	224	5	.	.	PROPN
admet-796	224	6	dowty	dowty	PROPN
admet-796	224	7	,	,	PUNCT
admet-796	224	8	t.h	t.h	PROPN
admet-796	224	9	.	.	PROPN
admet-796	224	10	lin	lin	PROPN
admet-796	224	11	,	,	PUNCT
admet-796	224	12	m.i	m.i	PROPN
admet-796	224	13	.	.	PROPN
admet-796	224	14	jesson	jesson	PROPN
admet-796	224	15	,	,	PUNCT
admet-796	224	16	m.	m.	PROPN
admet-796	224	17	hegen	hegen	PROPN
admet-796	224	18	,	,	PUNCT
admet-796	224	19	d.a	d.a	PROPN
admet-796	224	20	.	.	PROPN
admet-796	224	21	martin	martin	PROPN
admet-796	224	22	,	,	PUNCT
admet-796	224	23	v.	v.	PROPN
admet-796	224	24	katkade	katkade	PROPN
admet-796	224	25	,	,	PUNCT
admet-796	224	26	s.	s.	PROPN
admet-796	224	27	menon	menon	PROPN
admet-796	224	28	,	,	PUNCT
admet-796	224	29	j.b	j.b	PROPN
admet-796	224	30	.	.	PROPN
admet-796	224	31	telliez	telliez	NOUN
admet-796	224	32	.	.	PUNCT
admet-796	225	1	janus	janus	PROPN
admet-796	225	2	kinase	kinase	PROPN
admet-796	225	3	inhibitors	inhibitor	NOUN
admet-796	225	4	for	for	ADP
admet-796	225	5	the	the	DET
admet-796	225	6	treatment	treatment	NOUN
admet-796	225	7	of	of	ADP
admet-796	225	8	rheumatoid	rheumatoid	NOUN
admet-796	225	9	arthritis	arthritis	NOUN
admet-796	225	10	demonstrate	demonstrate	VERB
admet-796	225	11	similar	similar	ADJ
admet-796	225	12	profiles	profile	NOUN
admet-796	225	13	of	of	ADP
admet-796	225	14	in	in	ADP
admet-796	225	15	vitro	vitro	X
admet-796	225	16	cytokine	cytokine	ADJ
admet-796	225	17	receptor	receptor	NOUN
admet-796	225	18	inhibition	inhibition	NOUN
admet-796	225	19	.	.	PUNCT
admet-796	226	1	pharmacology	pharmacology	NOUN
admet-796	226	2	research	research	NOUN
admet-796	226	3	&	&	CCONJ
admet-796	226	4	perspectives	perspective	NOUN
admet-796	226	5	(	(	PUNCT
admet-796	226	6	2019	2019	NUM
admet-796	226	7	)	)	PUNCT
admet-796	226	8	e00537	e00537	PROPN
admet-796	226	9	.	.	PUNCT
admet-796	227	1	©	©	PROPN
admet-796	227	2	2020	2020	NUM
admet-796	227	3	by	by	ADP
admet-796	227	4	the	the	DET
admet-796	227	5	authors	author	NOUN
admet-796	227	6	;	;	PUNCT
admet-796	227	7	licensee	licensee	PROPN
admet-796	227	8	iapc	iapc	PROPN
admet-796	227	9	,	,	PUNCT
admet-796	227	10	zagreb	zagreb	PROPN
admet-796	227	11	,	,	PUNCT
admet-796	227	12	croatia	croatia	PROPN
admet-796	227	13	.	.	PUNCT
admet-796	228	1	this	this	DET
admet-796	228	2	article	article	NOUN
admet-796	228	3	is	be	AUX
admet-796	228	4	an	an	DET
admet-796	228	5	open	open	ADJ
admet-796	228	6	-	-	PUNCT
admet-796	228	7	access	access	NOUN
admet-796	228	8	article	article	NOUN
admet-796	228	9	distributed	distribute	VERB
admet-796	228	10	under	under	ADP
admet-796	228	11	the	the	DET
admet-796	228	12	terms	term	NOUN
admet-796	228	13	and	and	CCONJ
admet-796	228	14	conditions	condition	NOUN
admet-796	228	15	of	of	ADP
admet-796	228	16	the	the	DET
admet-796	228	17	creative	creative	ADJ
admet-796	228	18	commons	common	NOUN
admet-796	228	19	attribution	attribution	NOUN
admet-796	228	20	license	license	NOUN
admet-796	228	21	(	(	PUNCT
admet-796	228	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-796	228	23	)	)	PUNCT
admet-796	228	24	https://pj.jiho.jp/article/240785	https://pj.jiho.jp/article/240785	PROPN
admet-796	228	25	https://www.gilead.com/news-and-press/press-room/press-releases	https://www.gilead.com/news-and-press/press-room/press-release	VERB
admet-796	228	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN