id	sid	tid	token	lemma	pos
admet-797	1	1	permeation	permeation	NOUN
admet-797	1	2	characteristics	characteristic	NOUN
admet-797	1	3	of	of	ADP
admet-797	1	4	tetracyclines	tetracycline	NOUN
admet-797	1	5	in	in	ADP
admet-797	1	6	parallel	parallel	ADJ
admet-797	1	7	artificial	artificial	ADJ
admet-797	1	8	membrane	membrane	NOUN
admet-797	1	9	permeation	permeation	NOUN
admet-797	1	10	assay	assay	PROPN
admet-797	1	11	ii	ii	PROPN
admet-797	1	12	:	:	PUNCT
admet-797	1	13	effect	effect	NOUN
admet-797	1	14	of	of	ADP
admet-797	1	15	divalent	divalent	ADJ
admet-797	1	16	metal	metal	NOUN
admet-797	1	17	ions	ion	NOUN
admet-797	1	18	and	and	CCONJ
admet-797	1	19	mucin	mucin	NOUN
admet-797	1	20	doi	doi	PROPN
admet-797	1	21	:	:	PUNCT
admet-797	1	22	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	NOUN
admet-797	1	23	129	129	NUM
admet-797	1	24	admet	admet	PROPN
admet-797	1	25	&	&	CCONJ
admet-797	1	26	dmpk	dmpk	PROPN
admet-797	1	27	8(2	8(2	NUM
admet-797	1	28	)	)	PUNCT
admet-797	1	29	(	(	PUNCT
admet-797	1	30	2020	2020	NUM
admet-797	1	31	)	)	PUNCT
admet-797	1	32	129	129	NUM
admet-797	1	33	-	-	SYM
admet-797	1	34	138	138	NUM
admet-797	1	35	;	;	PUNCT
admet-797	1	36	doi	doi	NOUN
admet-797	1	37	:	:	PUNCT
admet-797	1	38	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	NOUN
admet-797	1	39	open	open	ADJ
admet-797	1	40	access	access	NOUN
admet-797	1	41	:	:	PUNCT
admet-797	1	42	issn	issn	PROPN
admet-797	1	43	:	:	PUNCT
admet-797	1	44	1848	1848	NUM
admet-797	1	45	-	-	SYM
admet-797	1	46	7718	7718	NUM
admet-797	1	47	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-797	1	48	original	original	ADJ
admet-797	1	49	scientific	scientific	ADJ
admet-797	1	50	paper	paper	NOUN
admet-797	1	51	permeation	permeation	NOUN
admet-797	1	52	characteristics	characteristic	NOUN
admet-797	1	53	of	of	ADP
admet-797	1	54	tetracyclines	tetracycline	NOUN
admet-797	1	55	in	in	ADP
admet-797	1	56	parallel	parallel	ADJ
admet-797	1	57	artificial	artificial	ADJ
admet-797	1	58	membrane	membrane	NOUN
admet-797	1	59	permeation	permeation	NOUN
admet-797	1	60	assay	assay	PROPN
admet-797	1	61	ii	ii	PROPN
admet-797	1	62	:	:	PUNCT
admet-797	1	63	effect	effect	NOUN
admet-797	1	64	of	of	ADP
admet-797	1	65	divalent	divalent	ADJ
admet-797	1	66	metal	metal	NOUN
admet-797	1	67	ions	ion	NOUN
admet-797	1	68	and	and	CCONJ
admet-797	1	69	mucin	mucin	PROPN
admet-797	1	70	sachika	sachika	PROPN
admet-797	1	71	yamauchi	yamauchi	PROPN
admet-797	1	72	,	,	PUNCT
admet-797	1	73	daisuke	daisuke	PROPN
admet-797	1	74	inoue	inoue	PROPN
admet-797	1	75	,	,	PUNCT
admet-797	1	76	kiyohiko	kiyohiko	PROPN
admet-797	1	77	sugano	sugano	NOUN
admet-797	1	78	*	*	PUNCT
admet-797	1	79	molecular	molecular	ADJ
admet-797	1	80	pharmaceutics	pharmaceutic	NOUN
admet-797	1	81	lab	lab	NOUN
admet-797	1	82	.	.	PUNCT
admet-797	1	83	,	,	PUNCT
admet-797	1	84	college	college	NOUN
admet-797	1	85	of	of	ADP
admet-797	1	86	pharmaceutical	pharmaceutical	NOUN
admet-797	1	87	sciences	science	NOUN
admet-797	1	88	,	,	PUNCT
admet-797	1	89	ritsumeikan	ritsumeikan	ADJ
admet-797	1	90	university	university	NOUN
admet-797	1	91	,	,	PUNCT
admet-797	1	92	1	1	NUM
admet-797	1	93	-	-	SYM
admet-797	1	94	1	1	NUM
admet-797	1	95	-	-	SYM
admet-797	1	96	1	1	NUM
admet-797	1	97	,	,	PUNCT
admet-797	1	98	noji	noji	NOUN
admet-797	1	99	-	-	PUNCT
admet-797	1	100	higashi	higashi	PROPN
admet-797	1	101	,	,	PUNCT
admet-797	1	102	kusatsu	kusatsu	NOUN
admet-797	1	103	,	,	PUNCT
admet-797	1	104	shiga	shiga	NOUN
admet-797	1	105	525	525	NUM
admet-797	1	106	-	-	SYM
admet-797	1	107	8577	8577	NUM
admet-797	1	108	,	,	PUNCT
admet-797	1	109	japan	japan	PROPN
admet-797	1	110	*	*	PUNCT
admet-797	1	111	corresponding	correspond	VERB
admet-797	1	112	author	author	NOUN
admet-797	1	113	:	:	PUNCT
admet-797	1	114	e	e	NOUN
admet-797	1	115	-	-	NOUN
admet-797	1	116	mail	mail	NOUN
admet-797	1	117	:	:	PUNCT
admet-797	1	118	suganok@fc.ritsumei.ac.jp	suganok@fc.ritsumei.ac.jp	NOUN
admet-797	1	119	;	;	PUNCT
admet-797	1	120	tel	tel	PROPN
admet-797	1	121	.	.	PROPN
admet-797	1	122	:	:	PUNCT
admet-797	2	1	+81	+81	PROPN
admet-797	2	2	-	-	PUNCT
admet-797	2	3	77	77	NUM
admet-797	2	4	-	-	PUNCT
admet-797	2	5	561	561	NUM
admet-797	2	6	-	-	PUNCT
admet-797	2	7	2773	2773	NUM
admet-797	2	8	received	receive	VERB
admet-797	2	9	:	:	PUNCT
admet-797	2	10	february	february	PROPN
admet-797	2	11	27	27	NUM
admet-797	2	12	,	,	PUNCT
admet-797	2	13	2020	2020	NUM
admet-797	2	14	;	;	PUNCT
admet-797	2	15	revised	revise	VERB
admet-797	2	16	:	:	PUNCT
admet-797	2	17	april	april	PROPN
admet-797	2	18	05	05	NUM
admet-797	2	19	,	,	PUNCT
admet-797	2	20	2020	2020	NUM
admet-797	2	21	;	;	PUNCT
admet-797	2	22	published	publish	VERB
admet-797	2	23	:	:	PUNCT
admet-797	2	24	may	may	AUX
admet-797	2	25	01	01	NUM
admet-797	2	26	,	,	PUNCT
admet-797	2	27	2020	2020	NUM
admet-797	2	28	abstract	abstract	VERB
admet-797	2	29	the	the	DET
admet-797	2	30	bioavailability	bioavailability	NOUN
admet-797	2	31	of	of	ADP
admet-797	2	32	tetracyclines	tetracyclines	PROPN
admet-797	2	33	is	be	AUX
admet-797	2	34	markedly	markedly	ADV
admet-797	2	35	decreased	decrease	VERB
admet-797	2	36	when	when	SCONJ
admet-797	2	37	co	co	VERB
admet-797	2	38	-	-	VERB
admet-797	2	39	administered	administer	VERB
admet-797	2	40	with	with	ADP
admet-797	2	41	antacids	antacid	NOUN
admet-797	2	42	,	,	PUNCT
admet-797	2	43	milk	milk	NOUN
admet-797	2	44	,	,	PUNCT
admet-797	2	45	or	or	CCONJ
admet-797	2	46	food	food	NOUN
admet-797	2	47	containing	contain	VERB
admet-797	2	48	ca	ca	NOUN
admet-797	2	49	2	2	NUM
admet-797	2	50	+	+	CCONJ
admet-797	2	51	.	.	PUNCT
admet-797	3	1	previously	previously	ADV
admet-797	3	2	,	,	PUNCT
admet-797	3	3	it	it	PRON
admet-797	3	4	was	be	AUX
admet-797	3	5	suggested	suggest	VERB
admet-797	3	6	that	that	SCONJ
admet-797	3	7	the	the	DET
admet-797	3	8	effective	effective	ADJ
admet-797	3	9	intestinal	intestinal	ADJ
admet-797	3	10	permeation	permeation	NOUN
admet-797	3	11	of	of	ADP
admet-797	3	12	tetracycline	tetracycline	PROPN
admet-797	3	13	(	(	PUNCT
admet-797	3	14	tc	tc	NOUN
admet-797	3	15	)	)	PUNCT
admet-797	3	16	was	be	AUX
admet-797	3	17	decreased	decrease	VERB
admet-797	3	18	due	due	ADP
admet-797	3	19	to	to	ADP
admet-797	3	20	ca	ca	PROPN
admet-797	3	21	2	2	NUM
admet-797	3	22	+	+	CCONJ
admet-797	3	23	linked	link	VERB
admet-797	3	24	mucin	mucin	NOUN
admet-797	3	25	binding	bind	VERB
admet-797	3	26	in	in	ADP
admet-797	3	27	the	the	DET
admet-797	3	28	mucosal	mucosal	NOUN
admet-797	3	29	side	side	NOUN
admet-797	3	30	.	.	PUNCT
admet-797	4	1	in	in	ADP
admet-797	4	2	the	the	DET
admet-797	4	3	present	present	ADJ
admet-797	4	4	study	study	NOUN
admet-797	4	5	,	,	PUNCT
admet-797	4	6	we	we	PRON
admet-797	4	7	investigated	investigate	VERB
admet-797	4	8	the	the	DET
admet-797	4	9	effect	effect	NOUN
admet-797	4	10	of	of	ADP
admet-797	4	11	ca	ca	NOUN
admet-797	4	12	2	2	NUM
admet-797	4	13	+	+	CCONJ
admet-797	4	14	,	,	PUNCT
admet-797	4	15	mg	mg	PROPN
admet-797	4	16	2	2	NUM
admet-797	4	17	+	+	NUM
admet-797	4	18	,	,	PUNCT
admet-797	4	19	and	and	CCONJ
admet-797	4	20	mucin	mucin	NOUN
admet-797	4	21	on	on	ADP
admet-797	4	22	the	the	DET
admet-797	4	23	membrane	membrane	NOUN
admet-797	4	24	permeation	permeation	NOUN
admet-797	4	25	of	of	ADP
admet-797	4	26	six	six	NUM
admet-797	4	27	tetracyclines	tetracycline	NOUN
admet-797	4	28	(	(	PUNCT
admet-797	4	29	tc	tc	NOUN
admet-797	4	30	,	,	PUNCT
admet-797	4	31	oxytetracycline	oxytetracycline	ADJ
admet-797	4	32	(	(	PUNCT
admet-797	4	33	otc	otc	PROPN
admet-797	4	34	)	)	PUNCT
admet-797	4	35	,	,	PUNCT
admet-797	4	36	minocycline	minocycline	NOUN
admet-797	4	37	(	(	PUNCT
admet-797	4	38	mino	mino	PROPN
admet-797	4	39	)	)	PUNCT
admet-797	4	40	,	,	PUNCT
admet-797	4	41	doxycycline	doxycycline	NOUN
admet-797	4	42	(	(	PUNCT
admet-797	4	43	doxy	doxy	PROPN
admet-797	4	44	)	)	PUNCT
admet-797	4	45	,	,	PUNCT
admet-797	4	46	demeclocycline	demeclocycline	NOUN
admet-797	4	47	(	(	PUNCT
admet-797	4	48	dmctc	dmctc	ADV
admet-797	4	49	)	)	PUNCT
admet-797	4	50	,	,	PUNCT
admet-797	4	51	and	and	CCONJ
admet-797	4	52	chlortetracycline	chlortetracycline	PROPN
admet-797	4	53	(	(	PUNCT
admet-797	4	54	ctc	ctc	PROPN
admet-797	4	55	)	)	PUNCT
admet-797	4	56	)	)	PUNCT
admet-797	4	57	.	.	PUNCT
admet-797	5	1	the	the	DET
admet-797	5	2	membrane	membrane	NOUN
admet-797	5	3	permeability	permeability	NOUN
admet-797	5	4	values	value	NOUN
admet-797	5	5	(	(	PUNCT
admet-797	5	6	pe	pe	INTJ
admet-797	5	7	)	)	PUNCT
admet-797	5	8	of	of	ADP
admet-797	5	9	tetracyclines	tetracycline	NOUN
admet-797	5	10	were	be	AUX
admet-797	5	11	measured	measure	VERB
admet-797	5	12	by	by	ADP
admet-797	5	13	the	the	DET
admet-797	5	14	parallel	parallel	ADJ
admet-797	5	15	artificial	artificial	ADJ
admet-797	5	16	membrane	membrane	NOUN
admet-797	5	17	permeation	permeation	NOUN
admet-797	5	18	assay	assay	NOUN
admet-797	5	19	(	(	PUNCT
admet-797	5	20	pampa	pampa	PROPN
admet-797	5	21	)	)	PUNCT
admet-797	5	22	using	use	VERB
admet-797	5	23	soybean	soybean	NOUN
admet-797	5	24	lecithin	lecithin	NOUN
admet-797	5	25	–	–	PUNCT
admet-797	5	26	decane	decane	NOUN
admet-797	5	27	(	(	PUNCT
admet-797	5	28	sl	sl	INTJ
admet-797	5	29	–	–	PUNCT
admet-797	5	30	pampa	pampa	NOUN
admet-797	5	31	)	)	PUNCT
admet-797	5	32	and	and	CCONJ
admet-797	5	33	octanol	octanol	NOUN
admet-797	5	34	(	(	PUNCT
admet-797	5	35	oct	oct	PROPN
admet-797	5	36	–	–	PUNCT
admet-797	5	37	pampa	pampa	NOUN
admet-797	5	38	)	)	PUNCT
admet-797	5	39	membranes	membrane	NOUN
admet-797	5	40	.	.	PUNCT
admet-797	6	1	in	in	ADP
admet-797	6	2	sl	sl	PROPN
admet-797	6	3	–	–	PUNCT
admet-797	6	4	pampa	pampa	NOUN
admet-797	6	5	,	,	PUNCT
admet-797	6	6	ca	ca	NOUN
admet-797	6	7	2	2	NUM
admet-797	6	8	+	+	CCONJ
admet-797	6	9	markedly	markedly	ADV
admet-797	6	10	decreased	decrease	VERB
admet-797	6	11	the	the	DET
admet-797	6	12	pe	pe	PROPN
admet-797	6	13	values	value	NOUN
admet-797	6	14	of	of	ADP
admet-797	6	15	all	all	DET
admet-797	6	16	tetracyclines	tetracycline	NOUN
admet-797	6	17	.	.	PUNCT
admet-797	7	1	in	in	ADP
admet-797	7	2	oct	oct	PROPN
admet-797	7	3	–	–	PUNCT
admet-797	7	4	pampa	pampa	PROPN
admet-797	7	5	,	,	PUNCT
admet-797	7	6	ca	ca	PROPN
admet-797	7	7	2	2	NUM
admet-797	7	8	+	+	CCONJ
admet-797	7	9	increased	increase	VERB
admet-797	7	10	the	the	DET
admet-797	7	11	pe	pe	PROPN
admet-797	7	12	values	value	NOUN
admet-797	7	13	of	of	ADP
admet-797	7	14	tc	tc	NOUN
admet-797	7	15	,	,	PUNCT
admet-797	7	16	ctc	ctc	NOUN
admet-797	7	17	,	,	PUNCT
admet-797	7	18	and	and	CCONJ
admet-797	7	19	dmctc	dmctc	NOUN
admet-797	7	20	,	,	PUNCT
admet-797	7	21	but	but	CCONJ
admet-797	7	22	not	not	PART
admet-797	7	23	doxy	doxy	PROPN
admet-797	7	24	,	,	PUNCT
admet-797	7	25	otc	otc	PROPN
admet-797	7	26	,	,	PUNCT
admet-797	7	27	and	and	CCONJ
admet-797	7	28	mino	mino	PROPN
admet-797	7	29	.	.	PUNCT
admet-797	8	1	mg	mg	PROPN
admet-797	8	2	2	2	NUM
admet-797	8	3	+	+	CCONJ
admet-797	8	4	decreased	decrease	VERB
admet-797	8	5	the	the	DET
admet-797	8	6	pe	pe	PROPN
admet-797	8	7	values	value	NOUN
admet-797	8	8	of	of	ADP
admet-797	8	9	all	all	DET
admet-797	8	10	tetracyclines	tetracycline	NOUN
admet-797	8	11	in	in	ADP
admet-797	8	12	both	both	PRON
admet-797	8	13	sl	sl	NOUN
admet-797	8	14	–	–	PUNCT
admet-797	8	15	pampa	pampa	PROPN
admet-797	8	16	and	and	CCONJ
admet-797	8	17	oct	oct	PROPN
admet-797	8	18	–	–	PUNCT
admet-797	8	19	pampa	pampa	PROPN
admet-797	8	20	(	(	PUNCT
admet-797	8	21	except	except	SCONJ
admet-797	8	22	for	for	ADP
admet-797	8	23	ctc	ctc	PROPN
admet-797	8	24	in	in	ADP
admet-797	8	25	oct	oct	PROPN
admet-797	8	26	–	–	PUNCT
admet-797	8	27	pampa	pampa	PROPN
admet-797	8	28	)	)	PUNCT
admet-797	8	29	.	.	PUNCT
admet-797	9	1	the	the	DET
admet-797	9	2	addition	addition	NOUN
admet-797	9	3	of	of	ADP
admet-797	9	4	mucin	mucin	NOUN
admet-797	9	5	had	have	VERB
admet-797	9	6	little	little	ADJ
admet-797	9	7	or	or	CCONJ
admet-797	9	8	no	no	PRON
admet-797	9	9	effect	effect	NOUN
admet-797	9	10	in	in	ADP
admet-797	9	11	all	all	DET
admet-797	9	12	cases	case	NOUN
admet-797	9	13	.	.	PUNCT
admet-797	10	1	in	in	ADP
admet-797	10	2	contrast	contrast	NOUN
admet-797	10	3	to	to	ADP
admet-797	10	4	the	the	DET
admet-797	10	5	previously	previously	ADV
admet-797	10	6	suggested	suggest	VERB
admet-797	10	7	mechanism	mechanism	NOUN
admet-797	10	8	,	,	PUNCT
admet-797	10	9	the	the	DET
admet-797	10	10	results	result	NOUN
admet-797	10	11	of	of	ADP
admet-797	10	12	the	the	DET
admet-797	10	13	present	present	ADJ
admet-797	10	14	study	study	NOUN
admet-797	10	15	suggested	suggest	VERB
admet-797	10	16	that	that	SCONJ
admet-797	10	17	ca	can	AUX
admet-797	10	18	2	2	NUM
admet-797	10	19	+	+	NUM
admet-797	10	20	chelate	chelate	NOUN
admet-797	10	21	formation	formation	NOUN
admet-797	10	22	decreased	decrease	VERB
admet-797	10	23	the	the	DET
admet-797	10	24	membrane	membrane	NOUN
admet-797	10	25	permeation	permeation	NOUN
admet-797	10	26	of	of	ADP
admet-797	10	27	tetracyclines	tetracycline	NOUN
admet-797	10	28	,	,	PUNCT
admet-797	10	29	irrespective	irrespective	ADV
admet-797	10	30	of	of	ADP
admet-797	10	31	ca	ca	PROPN
admet-797	10	32	2	2	NUM
admet-797	10	33	+	+	CCONJ
admet-797	10	34	linked	link	VERB
admet-797	10	35	mucin	mucin	NOUN
admet-797	10	36	binding	bind	VERB
admet-797	10	37	.	.	PUNCT
admet-797	11	1	molecular	molecular	ADJ
admet-797	11	2	speciation	speciation	NOUN
admet-797	11	3	analysis	analysis	NOUN
admet-797	11	4	suggested	suggest	VERB
admet-797	11	5	that	that	SCONJ
admet-797	11	6	the	the	DET
admet-797	11	7	permeation	permeation	NOUN
admet-797	11	8	of	of	ADP
admet-797	11	9	tc	tc	NUM
admet-797	11	10	–	–	PUNCT
admet-797	11	11	metal	metal	NOUN
admet-797	11	12	chelates	chelate	NOUN
admet-797	11	13	was	be	AUX
admet-797	11	14	negligibly	negligibly	ADV
admet-797	11	15	small	small	ADJ
admet-797	11	16	in	in	ADP
admet-797	11	17	sl	sl	NOUN
admet-797	11	18	-	-	PUNCT
admet-797	11	19	pampa	pampa	NOUN
admet-797	11	20	.	.	PUNCT
admet-797	12	1	©	©	PROPN
admet-797	12	2	2020	2020	NUM
admet-797	12	3	by	by	ADP
admet-797	12	4	the	the	DET
admet-797	12	5	authors	author	NOUN
admet-797	12	6	.	.	PUNCT
admet-797	13	1	this	this	DET
admet-797	13	2	article	article	NOUN
admet-797	13	3	is	be	AUX
admet-797	13	4	an	an	DET
admet-797	13	5	open	open	ADJ
admet-797	13	6	-	-	PUNCT
admet-797	13	7	access	access	NOUN
admet-797	13	8	article	article	NOUN
admet-797	13	9	distributed	distribute	VERB
admet-797	13	10	under	under	ADP
admet-797	13	11	the	the	DET
admet-797	13	12	terms	term	NOUN
admet-797	13	13	and	and	CCONJ
admet-797	13	14	conditions	condition	NOUN
admet-797	13	15	of	of	ADP
admet-797	13	16	the	the	DET
admet-797	13	17	creative	creative	ADJ
admet-797	13	18	commons	common	NOUN
admet-797	13	19	attribution	attribution	NOUN
admet-797	13	20	license	license	NOUN
admet-797	13	21	(	(	PUNCT
admet-797	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-797	13	23	)	)	PUNCT
admet-797	13	24	.	.	PUNCT
admet-797	14	1	keywords	keyword	VERB
admet-797	14	2	artificial	artificial	ADJ
admet-797	14	3	membrane	membrane	NOUN
admet-797	14	4	;	;	PUNCT
admet-797	14	5	permeability	permeability	NOUN
admet-797	14	6	;	;	PUNCT
admet-797	14	7	phospholipid	phospholipid	NOUN
admet-797	14	8	;	;	PUNCT
admet-797	14	9	tetracycline	tetracycline	NOUN
admet-797	14	10	;	;	PUNCT
admet-797	14	11	metal	metal	NOUN
admet-797	14	12	;	;	PUNCT
admet-797	14	13	cation	cation	NOUN
admet-797	14	14	;	;	PUNCT
admet-797	14	15	mucin	mucin	NOUN
admet-797	14	16	introduction	introduction	NOUN
admet-797	14	17	co	co	NOUN
admet-797	14	18	-	-	NOUN
admet-797	14	19	administration	administration	NOUN
admet-797	14	20	of	of	ADP
admet-797	14	21	multivalent	multivalent	NOUN
admet-797	14	22	metal	metal	NOUN
admet-797	14	23	ions	ion	NOUN
admet-797	14	24	reduces	reduce	VERB
admet-797	14	25	the	the	DET
admet-797	14	26	bioavailability	bioavailability	NOUN
admet-797	14	27	of	of	ADP
admet-797	14	28	various	various	ADJ
admet-797	14	29	drugs	drug	NOUN
admet-797	14	30	,	,	PUNCT
admet-797	14	31	such	such	ADJ
admet-797	14	32	as	as	ADP
admet-797	14	33	tetracyclines	tetracycline	NOUN
admet-797	14	34	,	,	PUNCT
admet-797	14	35	fluoroquinolones	fluoroquinolone	NOUN
admet-797	14	36	,	,	PUNCT
admet-797	14	37	hiv	hiv	PROPN
admet-797	14	38	-	-	PUNCT
admet-797	14	39	integrase	integrase	NOUN
admet-797	14	40	inhibitors	inhibitor	NOUN
admet-797	14	41	,	,	PUNCT
admet-797	14	42	and	and	CCONJ
admet-797	14	43	platelet	platelet	NOUN
admet-797	14	44	-	-	PUNCT
admet-797	14	45	stimulating	stimulate	VERB
admet-797	14	46	agents	agent	NOUN
admet-797	14	47	[	[	X
admet-797	14	48	1–4	1–4	NOUN
admet-797	14	49	]	]	X
admet-797	14	50	.	.	PUNCT
admet-797	15	1	for	for	ADP
admet-797	15	2	example	example	NOUN
admet-797	15	3	,	,	PUNCT
admet-797	15	4	the	the	DET
admet-797	15	5	bioavailability	bioavailability	NOUN
admet-797	15	6	of	of	ADP
admet-797	15	7	tetracyclines	tetracyclines	PROPN
admet-797	15	8	is	be	AUX
admet-797	15	9	markedly	markedly	ADV
admet-797	15	10	decreased	decrease	VERB
admet-797	15	11	when	when	SCONJ
admet-797	15	12	co	co	VERB
admet-797	15	13	-	-	VERB
admet-797	15	14	administered	administer	VERB
admet-797	15	15	with	with	ADP
admet-797	15	16	antacids	antacid	NOUN
admet-797	15	17	,	,	PUNCT
admet-797	15	18	milk	milk	NOUN
admet-797	15	19	,	,	PUNCT
admet-797	15	20	and	and	CCONJ
admet-797	15	21	food	food	NOUN
admet-797	15	22	containing	contain	VERB
admet-797	15	23	ca2	ca2	PROPN
admet-797	15	24	+	+	PROPN
admet-797	16	1	[	[	X
admet-797	16	2	4–10	4–10	NOUN
admet-797	16	3	]	]	PUNCT
admet-797	16	4	.	.	PUNCT
admet-797	17	1	it	it	PRON
admet-797	17	2	is	be	AUX
admet-797	17	3	generally	generally	ADV
admet-797	17	4	accepted	accept	VERB
admet-797	17	5	that	that	SCONJ
admet-797	17	6	chelate	chelate	NOUN
admet-797	17	7	formation	formation	NOUN
admet-797	17	8	between	between	ADP
admet-797	17	9	tetracycline	tetracycline	NOUN
admet-797	17	10	(	(	PUNCT
admet-797	17	11	tc	tc	NOUN
admet-797	17	12	)	)	PUNCT
admet-797	17	13	and	and	CCONJ
admet-797	17	14	ca2	ca2	PROPN
admet-797	17	15	+	+	PROPN
admet-797	17	16	is	be	AUX
admet-797	17	17	behind	behind	ADP
admet-797	17	18	the	the	DET
admet-797	17	19	observed	observe	VERB
admet-797	17	20	decrease	decrease	NOUN
admet-797	17	21	in	in	ADP
admet-797	17	22	the	the	DET
admet-797	17	23	bioavailability	bioavailability	NOUN
admet-797	17	24	of	of	ADP
admet-797	17	25	tetracyclines	tetracycline	NOUN
admet-797	17	26	[	[	X
admet-797	17	27	11–16	11–16	NUM
admet-797	17	28	]	]	PUNCT
admet-797	17	29	.	.	PUNCT
admet-797	18	1	chelate	chelate	NOUN
admet-797	18	2	formation	formation	NOUN
admet-797	18	3	of	of	ADP
admet-797	18	4	tetracyclines	tetracycline	NOUN
admet-797	18	5	has	have	AUX
admet-797	18	6	been	be	AUX
admet-797	18	7	extensively	extensively	ADV
admet-797	18	8	investigated	investigate	VERB
admet-797	18	9	(	(	PUNCT
admet-797	18	10	ref	ref	NOUN
admet-797	18	11	.	.	PUNCT
admet-797	19	1	[	[	X
admet-797	19	2	17	17	NUM
admet-797	19	3	]	]	PUNCT
admet-797	19	4	and	and	CCONJ
admet-797	19	5	references	reference	NOUN
admet-797	19	6	therein	therein	ADV
admet-797	19	7	)	)	PUNCT
admet-797	19	8	.	.	PUNCT
admet-797	20	1	however	however	ADV
admet-797	20	2	,	,	PUNCT
admet-797	20	3	the	the	DET
admet-797	20	4	exact	exact	ADJ
admet-797	20	5	mechanism	mechanism	NOUN
admet-797	20	6	of	of	ADP
admet-797	20	7	the	the	DET
admet-797	20	8	ca2	ca2	PROPN
admet-797	20	9	+	+	PROPN
admet-797	20	10	effect	effect	NOUN
admet-797	20	11	on	on	ADP
admet-797	20	12	the	the	DET
admet-797	20	13	bioavailability	bioavailability	NOUN
admet-797	20	14	of	of	ADP
admet-797	20	15	tetracyclines	tetracyclines	PROPN
admet-797	20	16	has	have	AUX
admet-797	20	17	not	not	PART
admet-797	20	18	been	be	AUX
admet-797	20	19	clear	clear	ADJ
admet-797	20	20	.	.	PUNCT
admet-797	21	1	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	21	2	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	21	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-797	21	4	mailto:suganok@fc.ritsumei.ac.jp	mailto:suganok@fc.ritsumei.ac.jp	PROPN
admet-797	21	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-797	21	6	kiyohiko	kiyohiko	PROPN
admet-797	21	7	sugano	sugano	PROPN
admet-797	22	1	et	et	PROPN
admet-797	22	2	al	al	PROPN
admet-797	22	3	.	.	PROPN
admet-797	22	4	admet	admet	PROPN
admet-797	22	5	&	&	CCONJ
admet-797	22	6	dmpk	dmpk	PROPN
admet-797	22	7	8(2	8(2	NUM
admet-797	22	8	)	)	PUNCT
admet-797	22	9	(	(	PUNCT
admet-797	22	10	2020	2020	NUM
admet-797	22	11	)	)	PUNCT
admet-797	22	12	129	129	NUM
admet-797	22	13	-	-	SYM
admet-797	22	14	138	138	NUM
admet-797	22	15	130	130	NUM
admet-797	22	16	several	several	ADJ
admet-797	22	17	ex	ex	NOUN
admet-797	22	18	-	-	NOUN
admet-797	22	19	vivo	vivo	ADJ
admet-797	22	20	and	and	CCONJ
admet-797	22	21	in	in	ADP
admet-797	22	22	-	-	PUNCT
admet-797	22	23	situ	situ	NOUN
admet-797	22	24	studies	study	NOUN
admet-797	22	25	have	have	AUX
admet-797	22	26	shown	show	VERB
admet-797	22	27	that	that	SCONJ
admet-797	22	28	divalent	divalent	ADJ
admet-797	22	29	metal	metal	NOUN
admet-797	22	30	ions	ion	NOUN
admet-797	22	31	,	,	PUNCT
admet-797	22	32	such	such	ADJ
admet-797	22	33	as	as	ADP
admet-797	22	34	ca	ca	NOUN
admet-797	22	35	2	2	NUM
admet-797	22	36	+	+	CCONJ
admet-797	22	37	,	,	PUNCT
admet-797	22	38	mg	mg	PROPN
admet-797	22	39	2	2	NUM
admet-797	22	40	+	+	NOUN
admet-797	22	41	,	,	PUNCT
admet-797	22	42	and	and	CCONJ
admet-797	22	43	fe	fe	X
admet-797	23	1	2	2	NUM
admet-797	23	2	+	+	CCONJ
admet-797	23	3	,	,	PUNCT
admet-797	23	4	reduce	reduce	VERB
admet-797	23	5	the	the	DET
admet-797	23	6	intestinal	intestinal	ADJ
admet-797	23	7	wall	wall	NOUN
admet-797	23	8	permeation	permeation	NOUN
admet-797	23	9	of	of	ADP
admet-797	23	10	tetracyclines	tetracycline	NOUN
admet-797	23	11	[	[	X
admet-797	23	12	18–22	18–22	NUM
admet-797	23	13	]	]	PUNCT
admet-797	23	14	.	.	PUNCT
admet-797	24	1	in	in	ADP
admet-797	24	2	1968	1968	NUM
admet-797	24	3	,	,	PUNCT
admet-797	24	4	kakemi	kakemi	VERB
admet-797	24	5	et	et	PROPN
admet-797	24	6	al	al	PROPN
admet-797	24	7	.	.	PROPN
admet-797	24	8	investigated	investigate	VERB
admet-797	24	9	the	the	DET
admet-797	24	10	effect	effect	NOUN
admet-797	24	11	of	of	ADP
admet-797	24	12	ca2	ca2	PROPN
admet-797	24	13	+	+	X
admet-797	24	14	on	on	ADP
admet-797	24	15	the	the	DET
admet-797	24	16	effective	effective	ADJ
admet-797	24	17	intestinal	intestinal	ADJ
admet-797	24	18	wall	wall	NOUN
admet-797	24	19	permeation	permeation	NOUN
admet-797	24	20	of	of	ADP
admet-797	24	21	tetracycline	tetracycline	PROPN
admet-797	24	22	(	(	PUNCT
admet-797	24	23	tc	tc	NOUN
admet-797	24	24	)	)	PUNCT
admet-797	24	25	using	use	VERB
admet-797	24	26	the	the	DET
admet-797	24	27	rat	rat	NOUN
admet-797	24	28	small	small	ADJ
admet-797	24	29	intestine	intestine	NOUN
admet-797	25	1	[	[	X
admet-797	25	2	21,22	21,22	NOUN
admet-797	25	3	]	]	X
admet-797	25	4	.	.	PUNCT
admet-797	26	1	they	they	PRON
admet-797	26	2	also	also	ADV
admet-797	26	3	measured	measure	VERB
admet-797	26	4	the	the	DET
admet-797	26	5	isopentanol	isopentanol	NOUN
admet-797	26	6	–	–	PUNCT
admet-797	26	7	buffer	buffer	NOUN
admet-797	26	8	partition	partition	NOUN
admet-797	26	9	coefficient	coefficient	NOUN
admet-797	26	10	as	as	ADP
admet-797	26	11	a	a	DET
admet-797	26	12	surrogate	surrogate	NOUN
admet-797	26	13	of	of	ADP
admet-797	26	14	passive	passive	ADJ
admet-797	26	15	transcellular	transcellular	ADJ
admet-797	26	16	membrane	membrane	NOUN
admet-797	26	17	permeability	permeability	NOUN
admet-797	26	18	without	without	ADP
admet-797	26	19	the	the	DET
admet-797	26	20	interference	interference	NOUN
admet-797	26	21	from	from	ADP
admet-797	26	22	mucin	mucin	PROPN
admet-797	26	23	.	.	PUNCT
admet-797	27	1	they	they	PRON
admet-797	27	2	found	find	VERB
admet-797	27	3	that	that	PRON
admet-797	27	4	ca	can	AUX
admet-797	27	5	2	2	NUM
admet-797	27	6	+	+	CCONJ
admet-797	27	7	decreased	decrease	VERB
admet-797	27	8	the	the	DET
admet-797	27	9	effective	effective	ADJ
admet-797	27	10	intestinal	intestinal	ADJ
admet-797	27	11	wall	wall	NOUN
admet-797	27	12	permeation	permeation	NOUN
admet-797	27	13	of	of	ADP
admet-797	27	14	tc	tc	PRON
admet-797	27	15	in	in	ADP
admet-797	27	16	the	the	DET
admet-797	27	17	rat	rat	NOUN
admet-797	27	18	ex	ex	ADJ
admet-797	27	19	-	-	ADJ
admet-797	27	20	vivo	vivo	ADJ
admet-797	27	21	experiment	experiment	NOUN
admet-797	27	22	,	,	PUNCT
admet-797	27	23	but	but	CCONJ
admet-797	27	24	increased	increase	VERB
admet-797	27	25	the	the	DET
admet-797	27	26	partition	partition	NOUN
admet-797	27	27	coefficient	coefficient	NOUN
admet-797	27	28	of	of	ADP
admet-797	27	29	tc	tc	NOUN
admet-797	27	30	.	.	PUNCT
admet-797	28	1	they	they	PRON
admet-797	28	2	also	also	ADV
admet-797	28	3	found	find	VERB
admet-797	28	4	that	that	SCONJ
admet-797	28	5	tc	tc	NOUN
admet-797	28	6	bound	bind	VERB
admet-797	28	7	to	to	ADP
admet-797	28	8	the	the	DET
admet-797	28	9	intestinal	intestinal	ADJ
admet-797	28	10	mucin	mucin	NOUN
admet-797	28	11	layer	layer	NOUN
admet-797	28	12	in	in	ADP
admet-797	28	13	the	the	DET
admet-797	28	14	presence	presence	NOUN
admet-797	28	15	of	of	ADP
admet-797	28	16	ca	ca	NOUN
admet-797	28	17	2	2	NUM
admet-797	28	18	+	+	NUM
admet-797	28	19	.	.	PUNCT
admet-797	29	1	based	base	VERB
admet-797	29	2	on	on	ADP
admet-797	29	3	these	these	DET
admet-797	29	4	observations	observation	NOUN
admet-797	29	5	,	,	PUNCT
admet-797	29	6	they	they	PRON
admet-797	29	7	suggested	suggest	VERB
admet-797	29	8	that	that	SCONJ
admet-797	29	9	ca	can	AUX
admet-797	29	10	2	2	NUM
admet-797	29	11	+	+	CCONJ
admet-797	29	12	linked	link	VERB
admet-797	29	13	mucin	mucin	PROPN
admet-797	29	14	binding	binding	PROPN
admet-797	29	15	decreased	decrease	VERB
admet-797	29	16	the	the	DET
admet-797	29	17	tc	tc	NOUN
admet-797	29	18	concentration	concentration	NOUN
admet-797	29	19	available	available	ADJ
admet-797	29	20	for	for	ADP
admet-797	29	21	membrane	membrane	NOUN
admet-797	29	22	permeation	permeation	NOUN
admet-797	29	23	,	,	PUNCT
admet-797	29	24	resulting	result	VERB
admet-797	29	25	in	in	ADP
admet-797	29	26	a	a	DET
admet-797	29	27	decrease	decrease	NOUN
admet-797	29	28	in	in	ADP
admet-797	29	29	the	the	DET
admet-797	29	30	effective	effective	ADJ
admet-797	29	31	intestinal	intestinal	ADJ
admet-797	29	32	wall	wall	NOUN
admet-797	29	33	permeation	permeation	PROPN
admet-797	29	34	.	.	PUNCT
admet-797	30	1	schumacher	schumacher	PROPN
admet-797	30	2	and	and	CCONJ
admet-797	30	3	linn	linn	PROPN
admet-797	30	4	also	also	ADV
admet-797	30	5	reported	report	VERB
admet-797	30	6	that	that	SCONJ
admet-797	30	7	ca2	ca2	PROPN
admet-797	30	8	+	+	PROPN
admet-797	30	9	increased	increase	VERB
admet-797	30	10	the	the	DET
admet-797	30	11	transfer	transfer	NOUN
admet-797	30	12	rate	rate	NOUN
admet-797	30	13	of	of	ADP
admet-797	30	14	tc	tc	NUM
admet-797	30	15	from	from	ADP
admet-797	30	16	the	the	DET
admet-797	30	17	aqueous	aqueous	ADJ
admet-797	30	18	phase	phase	NOUN
admet-797	30	19	to	to	ADP
admet-797	30	20	the	the	DET
admet-797	30	21	octanol	octanol	NOUN
admet-797	30	22	phase	phase	NOUN
admet-797	30	23	[	[	X
admet-797	30	24	23	23	NUM
admet-797	30	25	]	]	PUNCT
admet-797	30	26	.	.	PUNCT
admet-797	31	1	however	however	ADV
admet-797	31	2	,	,	PUNCT
admet-797	31	3	it	it	PRON
admet-797	31	4	is	be	AUX
admet-797	31	5	questionable	questionable	ADJ
admet-797	31	6	whether	whether	SCONJ
admet-797	31	7	these	these	DET
admet-797	31	8	alcohol	alcohol	NOUN
admet-797	31	9	systems	system	NOUN
admet-797	31	10	could	could	AUX
admet-797	31	11	be	be	AUX
admet-797	31	12	a	a	DET
admet-797	31	13	good	good	ADJ
admet-797	31	14	surrogate	surrogate	ADJ
admet-797	31	15	model	model	NOUN
admet-797	31	16	for	for	ADP
admet-797	31	17	investigating	investigate	VERB
admet-797	31	18	the	the	DET
admet-797	31	19	effect	effect	NOUN
admet-797	31	20	of	of	ADP
admet-797	31	21	divalent	divalent	ADJ
admet-797	31	22	metal	metal	NOUN
admet-797	31	23	ions	ion	NOUN
admet-797	31	24	on	on	ADP
admet-797	31	25	the	the	DET
admet-797	31	26	membrane	membrane	NOUN
admet-797	31	27	permeation	permeation	NOUN
admet-797	31	28	of	of	ADP
admet-797	31	29	drugs	drug	NOUN
admet-797	31	30	.	.	PUNCT
admet-797	32	1	since	since	SCONJ
admet-797	32	2	divalent	divalent	ADJ
admet-797	32	3	metal	metal	NOUN
admet-797	32	4	ions	ion	NOUN
admet-797	32	5	may	may	AUX
admet-797	32	6	affect	affect	VERB
admet-797	32	7	cellular	cellular	ADJ
admet-797	32	8	integrity	integrity	NOUN
admet-797	32	9	,	,	PUNCT
admet-797	32	10	mucin	mucin	NOUN
admet-797	32	11	-	-	PUNCT
admet-797	32	12	free	free	ADJ
admet-797	32	13	cell	cell	NOUN
admet-797	32	14	-	-	PUNCT
admet-797	32	15	based	base	VERB
admet-797	32	16	systems	system	NOUN
admet-797	32	17	such	such	ADJ
admet-797	32	18	as	as	ADP
admet-797	32	19	caco-2	caco-2	NUM
admet-797	32	20	have	have	AUX
admet-797	32	21	rarely	rarely	ADV
admet-797	32	22	been	be	AUX
admet-797	32	23	used	use	VERB
admet-797	32	24	to	to	PART
admet-797	32	25	examine	examine	VERB
admet-797	32	26	the	the	DET
admet-797	32	27	effects	effect	NOUN
admet-797	32	28	of	of	ADP
admet-797	32	29	multivalent	multivalent	NOUN
admet-797	32	30	metal	metal	NOUN
admet-797	32	31	ions	ion	NOUN
admet-797	32	32	on	on	ADP
admet-797	32	33	membrane	membrane	NOUN
admet-797	32	34	permeation	permeation	NOUN
admet-797	32	35	[	[	X
admet-797	32	36	24,25	24,25	NUM
admet-797	32	37	]	]	PUNCT
admet-797	32	38	.	.	PUNCT
admet-797	33	1	the	the	DET
admet-797	33	2	parallel	parallel	ADJ
admet-797	33	3	artificial	artificial	ADJ
admet-797	33	4	membrane	membrane	NOUN
admet-797	33	5	permeation	permeation	NOUN
admet-797	33	6	assay	assay	NOUN
admet-797	33	7	(	(	PUNCT
admet-797	33	8	pampa	pampa	PROPN
admet-797	33	9	)	)	PUNCT
admet-797	33	10	has	have	AUX
admet-797	33	11	been	be	AUX
admet-797	33	12	widely	widely	ADV
admet-797	33	13	used	use	VERB
admet-797	33	14	to	to	PART
admet-797	33	15	assess	assess	VERB
admet-797	33	16	the	the	DET
admet-797	33	17	passive	passive	ADJ
admet-797	33	18	membrane	membrane	NOUN
admet-797	33	19	permeation	permeation	NOUN
admet-797	33	20	of	of	ADP
admet-797	33	21	a	a	DET
admet-797	33	22	drug	drug	NOUN
admet-797	34	1	[	[	X
admet-797	34	2	26–29	26–29	NOUN
admet-797	34	3	]	]	X
admet-797	34	4	.	.	PUNCT
admet-797	35	1	phospholipid	phospholipid	NOUN
admet-797	35	2	-	-	PUNCT
admet-797	35	3	based	base	VERB
admet-797	35	4	artificial	artificial	ADJ
admet-797	35	5	membranes	membrane	NOUN
admet-797	35	6	are	be	AUX
admet-797	35	7	most	most	ADV
admet-797	35	8	commonly	commonly	ADV
admet-797	35	9	used	use	VERB
admet-797	35	10	with	with	ADP
admet-797	35	11	pampa	pampa	PROPN
admet-797	35	12	.	.	PUNCT
admet-797	36	1	pampa	pampa	PROPN
admet-797	36	2	permeability	permeability	NOUN
admet-797	36	3	correlates	correlate	VERB
admet-797	36	4	with	with	ADP
admet-797	36	5	the	the	DET
admet-797	36	6	in	in	ADP
admet-797	36	7	vivo	vivo	NOUN
admet-797	36	8	and	and	CCONJ
admet-797	36	9	cellular	cellular	ADJ
admet-797	36	10	permeation	permeation	NOUN
admet-797	36	11	of	of	ADP
admet-797	36	12	drugs	drug	NOUN
admet-797	36	13	better	well	ADV
admet-797	36	14	than	than	ADP
admet-797	36	15	the	the	DET
admet-797	36	16	octanol	octanol	NOUN
admet-797	36	17	-	-	PUNCT
admet-797	36	18	buffer	buffer	NOUN
admet-797	36	19	partition	partition	NOUN
admet-797	36	20	coefficient	coefficient	NOUN
admet-797	36	21	[	[	X
admet-797	36	22	27,28	27,28	NUM
admet-797	36	23	]	]	X
admet-797	36	24	.	.	PUNCT
admet-797	37	1	recently	recently	ADV
admet-797	37	2	,	,	PUNCT
admet-797	37	3	we	we	PRON
admet-797	37	4	reported	report	VERB
admet-797	37	5	the	the	DET
admet-797	37	6	permeation	permeation	NOUN
admet-797	37	7	characteristics	characteristic	NOUN
admet-797	37	8	of	of	ADP
admet-797	37	9	tetracyclines	tetracycline	NOUN
admet-797	37	10	in	in	ADP
admet-797	37	11	a	a	DET
admet-797	37	12	phospholipid	phospholipid	NOUN
admet-797	37	13	-	-	PUNCT
admet-797	37	14	based	base	VERB
admet-797	37	15	pampa	pampa	NOUN
admet-797	37	16	[	[	X
admet-797	37	17	30	30	NUM
admet-797	37	18	]	]	PUNCT
admet-797	37	19	.	.	PUNCT
admet-797	38	1	only	only	ADV
admet-797	38	2	a	a	DET
admet-797	38	3	weak	weak	ADJ
admet-797	38	4	correlation	correlation	NOUN
admet-797	38	5	was	be	AUX
admet-797	38	6	observed	observe	VERB
admet-797	38	7	between	between	ADP
admet-797	38	8	the	the	DET
admet-797	38	9	pampa	pampa	NOUN
admet-797	38	10	permeability	permeability	NOUN
admet-797	38	11	(	(	PUNCT
admet-797	38	12	pe	pe	NOUN
admet-797	38	13	)	)	PUNCT
admet-797	38	14	and	and	CCONJ
admet-797	38	15	the	the	DET
admet-797	38	16	octanol	octanol	NOUN
admet-797	38	17	-	-	PUNCT
admet-797	38	18	buffer	buffer	NOUN
admet-797	38	19	partition	partition	NOUN
admet-797	38	20	coefficients	coefficient	NOUN
admet-797	38	21	(	(	PUNCT
admet-797	38	22	log	log	PROPN
admet-797	38	23	doct	doct	PROPN
admet-797	38	24	)	)	PUNCT
admet-797	38	25	for	for	ADP
admet-797	38	26	tetracyclines	tetracycline	NOUN
admet-797	38	27	,	,	PUNCT
admet-797	38	28	suggesting	suggest	VERB
admet-797	38	29	that	that	SCONJ
admet-797	38	30	chemoselectivity	chemoselectivity	NOUN
admet-797	38	31	differs	differ	VERB
admet-797	38	32	between	between	ADP
admet-797	38	33	these	these	DET
admet-797	38	34	systems	system	NOUN
admet-797	38	35	.	.	PUNCT
admet-797	39	1	however	however	ADV
admet-797	39	2	,	,	PUNCT
admet-797	39	3	the	the	DET
admet-797	39	4	effects	effect	NOUN
admet-797	39	5	of	of	ADP
admet-797	39	6	divalent	divalent	ADJ
admet-797	39	7	metal	metal	NOUN
admet-797	39	8	ions	ion	NOUN
admet-797	39	9	on	on	ADP
admet-797	39	10	the	the	DET
admet-797	39	11	pampa	pampa	PROPN
admet-797	39	12	permeation	permeation	NOUN
admet-797	39	13	of	of	ADP
admet-797	39	14	tetracyclines	tetracycline	NOUN
admet-797	39	15	have	have	AUX
admet-797	39	16	been	be	AUX
admet-797	39	17	unknown	unknown	ADJ
admet-797	39	18	.	.	PUNCT
admet-797	40	1	the	the	DET
admet-797	40	2	purpose	purpose	NOUN
admet-797	40	3	of	of	ADP
admet-797	40	4	the	the	DET
admet-797	40	5	present	present	ADJ
admet-797	40	6	study	study	NOUN
admet-797	40	7	was	be	AUX
admet-797	40	8	to	to	PART
admet-797	40	9	investigate	investigate	VERB
admet-797	40	10	the	the	DET
admet-797	40	11	effect	effect	NOUN
admet-797	40	12	of	of	ADP
admet-797	40	13	ca2	ca2	PROPN
admet-797	40	14	+	+	PROPN
admet-797	40	15	,	,	PUNCT
admet-797	40	16	mg2	mg2	PROPN
admet-797	40	17	+	+	PROPN
admet-797	40	18	,	,	PUNCT
admet-797	40	19	and	and	CCONJ
admet-797	40	20	mucin	mucin	NOUN
admet-797	40	21	on	on	ADP
admet-797	40	22	the	the	DET
admet-797	40	23	phospholipid	phospholipid	NOUN
admet-797	40	24	-	-	PUNCT
admet-797	40	25	based	base	VERB
admet-797	40	26	pampa	pampa	PROPN
admet-797	40	27	permeation	permeation	NOUN
admet-797	40	28	of	of	ADP
admet-797	40	29	tetracyclines	tetracyclines	PROPN
admet-797	40	30	.	.	PUNCT
admet-797	41	1	six	six	NUM
admet-797	41	2	tetracycline	tetracycline	NOUN
admet-797	41	3	derivatives	derivative	NOUN
admet-797	41	4	were	be	AUX
admet-797	41	5	used	use	VERB
admet-797	41	6	in	in	ADP
admet-797	41	7	this	this	DET
admet-797	41	8	study	study	NOUN
admet-797	41	9	(	(	PUNCT
admet-797	41	10	figure	figure	NOUN
admet-797	41	11	1	1	NUM
admet-797	41	12	)	)	PUNCT
admet-797	41	13	.	.	PUNCT
admet-797	42	1	the	the	DET
admet-797	42	2	physicochemical	physicochemical	ADJ
admet-797	42	3	properties	property	NOUN
admet-797	42	4	of	of	ADP
admet-797	42	5	these	these	DET
admet-797	42	6	tetracyclines	tetracycline	NOUN
admet-797	42	7	have	have	AUX
admet-797	42	8	been	be	AUX
admet-797	42	9	summarized	summarize	VERB
admet-797	42	10	in	in	ADP
admet-797	42	11	table	table	NOUN
admet-797	42	12	1	1	NUM
admet-797	43	1	[	[	X
admet-797	43	2	31–33	31–33	NUM
admet-797	43	3	]	]	PUNCT
admet-797	43	4	.	.	PUNCT
admet-797	44	1	figure	figure	NOUN
admet-797	44	2	1	1	NUM
admet-797	44	3	.	.	PUNCT
admet-797	45	1	chemical	chemical	NOUN
admet-797	45	2	structures	structure	NOUN
admet-797	45	3	of	of	ADP
admet-797	45	4	tetracyclines	tetracycline	NOUN
admet-797	45	5	experimental	experimental	ADJ
admet-797	45	6	materials	material	NOUN
admet-797	45	7	tetracycline	tetracycline	NOUN
admet-797	45	8	hydrochloride	hydrochloride	NOUN
admet-797	45	9	(	(	PUNCT
admet-797	45	10	tc	tc	NOUN
admet-797	45	11	)	)	PUNCT
admet-797	45	12	,	,	PUNCT
admet-797	45	13	decane	decane	PROPN
admet-797	45	14	,	,	PUNCT
admet-797	45	15	calcium	calcium	NOUN
admet-797	45	16	dichloride	dichloride	NOUN
admet-797	45	17	,	,	PUNCT
admet-797	45	18	magnesium	magnesium	NOUN
admet-797	45	19	dichloride	dichloride	NOUN
admet-797	45	20	,	,	PUNCT
admet-797	45	21	octanol	octanol	NOUN
admet-797	45	22	,	,	PUNCT
admet-797	45	23	pig	pig	NOUN
admet-797	45	24	stomach	stomach	NOUN
admet-797	45	25	mucin	mucin	NOUN
admet-797	45	26	,	,	PUNCT
admet-797	45	27	and	and	CCONJ
admet-797	45	28	8	8	NUM
admet-797	45	29	m	m	NOUN
admet-797	45	30	naoh	naoh	NOUN
admet-797	45	31	were	be	AUX
admet-797	45	32	purchased	purchase	VERB
admet-797	45	33	from	from	ADP
admet-797	45	34	wako	wako	PROPN
admet-797	45	35	pure	pure	ADJ
admet-797	45	36	chemical	chemical	NOUN
admet-797	45	37	industries	industry	NOUN
admet-797	45	38	,	,	PUNCT
admet-797	45	39	ltd	ltd	PROPN
admet-797	45	40	(	(	PUNCT
admet-797	45	41	osaka	osaka	PROPN
admet-797	45	42	,	,	PUNCT
admet-797	45	43	japan	japan	PROPN
admet-797	45	44	)	)	PUNCT
admet-797	45	45	.	.	PUNCT
admet-797	46	1	admet	admet	PROPN
admet-797	46	2	&	&	CCONJ
admet-797	46	3	dmpk	dmpk	PROPN
admet-797	46	4	8(2	8(2	NUM
admet-797	46	5	)	)	PUNCT
admet-797	46	6	(	(	PUNCT
admet-797	46	7	2020	2020	NUM
admet-797	46	8	)	)	PUNCT
admet-797	46	9	129	129	NUM
admet-797	46	10	-	-	SYM
admet-797	46	11	138	138	NUM
admet-797	46	12	effect	effect	NOUN
admet-797	46	13	of	of	ADP
admet-797	46	14	metal	metal	NOUN
admet-797	46	15	ions	ion	NOUN
admet-797	46	16	on	on	ADP
admet-797	46	17	pampa	pampa	PROPN
admet-797	46	18	permeation	permeation	NOUN
admet-797	46	19	of	of	ADP
admet-797	46	20	tetracyclines	tetracyclines	PROPN
admet-797	46	21	doi	doi	PROPN
admet-797	46	22	:	:	PUNCT
admet-797	46	23	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	NOUN
admet-797	46	24	131	131	NUM
admet-797	46	25	oxytetracycline	oxytetracycline	ADJ
admet-797	46	26	hydrochloride	hydrochloride	NOUN
admet-797	46	27	(	(	PUNCT
admet-797	46	28	otc	otc	PROPN
admet-797	46	29	)	)	PUNCT
admet-797	46	30	,	,	PUNCT
admet-797	46	31	minocycline	minocycline	ADJ
admet-797	46	32	hydrochloride	hydrochloride	NOUN
admet-797	46	33	(	(	PUNCT
admet-797	46	34	mino	mino	PROPN
admet-797	46	35	)	)	PUNCT
admet-797	46	36	,	,	PUNCT
admet-797	46	37	and	and	CCONJ
admet-797	46	38	doxycycline	doxycycline	NOUN
admet-797	46	39	hyclate	hyclate	PROPN
admet-797	46	40	(	(	PUNCT
admet-797	46	41	doxy	doxy	PROPN
admet-797	46	42	)	)	PUNCT
admet-797	46	43	were	be	AUX
admet-797	46	44	purchased	purchase	VERB
admet-797	46	45	from	from	ADP
admet-797	46	46	tci	tci	PROPN
admet-797	46	47	(	(	PUNCT
admet-797	46	48	tokyo	tokyo	PROPN
admet-797	46	49	,	,	PUNCT
admet-797	46	50	japan	japan	PROPN
admet-797	46	51	)	)	PUNCT
admet-797	46	52	.	.	PUNCT
admet-797	47	1	2	2	NUM
admet-797	47	2	-	-	PUNCT
admet-797	47	3	morpholinoethanesulfonic	morpholinoethanesulfonic	ADJ
admet-797	47	4	acid	acid	NOUN
admet-797	47	5	(	(	PUNCT
admet-797	47	6	mes	me	NOUN
admet-797	47	7	)	)	PUNCT
admet-797	47	8	was	be	AUX
admet-797	47	9	purchased	purchase	VERB
admet-797	47	10	from	from	ADP
admet-797	47	11	dojindo	dojindo	ADJ
admet-797	47	12	laboratories	laboratory	NOUN
admet-797	47	13	(	(	PUNCT
admet-797	47	14	tokyo	tokyo	PROPN
admet-797	47	15	,	,	PUNCT
admet-797	47	16	japan	japan	PROPN
admet-797	47	17	)	)	PUNCT
admet-797	47	18	.	.	PUNCT
admet-797	48	1	demeclocycline	demeclocycline	ADJ
admet-797	48	2	hydrochloride	hydrochloride	NOUN
admet-797	48	3	(	(	PUNCT
admet-797	48	4	dmctc	dmctc	ADV
admet-797	48	5	)	)	PUNCT
admet-797	48	6	and	and	CCONJ
admet-797	48	7	chlortetracycline	chlortetracycline	VERB
admet-797	48	8	hydrochloride	hydrochloride	NOUN
admet-797	48	9	(	(	PUNCT
admet-797	48	10	ctc	ctc	PROPN
admet-797	48	11	)	)	PUNCT
admet-797	48	12	were	be	AUX
admet-797	48	13	purchased	purchase	VERB
admet-797	48	14	from	from	ADP
admet-797	48	15	lkt	lkt	PROPN
admet-797	48	16	labs	labs	PROPN
admet-797	48	17	,	,	PUNCT
admet-797	48	18	inc	inc	PROPN
admet-797	48	19	(	(	PUNCT
admet-797	48	20	mn	mn	PROPN
admet-797	48	21	,	,	PUNCT
admet-797	48	22	usa	usa	PROPN
admet-797	48	23	)	)	PUNCT
admet-797	48	24	.	.	PUNCT
admet-797	49	1	soybean	soybean	NOUN
admet-797	49	2	lecithin	lecithin	NOUN
admet-797	49	3	(	(	PUNCT
admet-797	49	4	slp	slp	PROPN
admet-797	49	5	-	-	PUNCT
admet-797	49	6	white	white	PROPN
admet-797	49	7	)	)	PUNCT
admet-797	49	8	was	be	AUX
admet-797	49	9	provided	provide	VERB
admet-797	49	10	by	by	ADP
admet-797	49	11	tsuji	tsuji	PROPN
admet-797	49	12	oil	oil	PROPN
admet-797	49	13	mills	mills	PROPN
admet-797	49	14	co.	co.	PROPN
admet-797	49	15	,	,	PUNCT
admet-797	49	16	ltd	ltd	PROPN
admet-797	49	17	(	(	PUNCT
admet-797	49	18	mie	mie	PROPN
admet-797	49	19	,	,	PUNCT
admet-797	49	20	japan	japan	PROPN
admet-797	49	21	)	)	PUNCT
admet-797	49	22	.	.	PUNCT
admet-797	50	1	table	table	NOUN
admet-797	50	2	1	1	NUM
admet-797	50	3	.	.	PUNCT
admet-797	50	4	physicochemical	physicochemical	ADJ
admet-797	50	5	properties	property	NOUN
admet-797	50	6	of	of	ADP
admet-797	50	7	tetracyclines	tetracyclines	PROPN
admet-797	50	8	mw	mw	X
admet-797	50	9	pka	pka	PROPN
admet-797	50	10	log	log	NOUN
admet-797	50	11	doct	doct	PROPN
admet-797	50	12	(	(	PUNCT
admet-797	50	13	ph	ph	PROPN
admet-797	50	14	6.5	6.5	NUM
admet-797	50	15	)	)	PUNCT
admet-797	50	16	a	a	DET
admet-797	50	17	pka	pka	PROPN
admet-797	50	18	ref	ref	NOUN
admet-797	50	19	.	.	PUNCT
admet-797	51	1	chlortetracycline	chlortetracycline	VERB
admet-797	51	2	479	479	NUM
admet-797	51	3	3.3	3.3	NUM
admet-797	51	4	,	,	PUNCT
admet-797	51	5	7.6	7.6	NUM
admet-797	51	6	,	,	PUNCT
admet-797	51	7	9.3	9.3	NUM
admet-797	51	8	-0.88	-0.88	NOUN
admet-797	52	1	[	[	X
admet-797	52	2	31	31	NUM
admet-797	52	3	]	]	SYM
admet-797	52	4	b	b	PROPN
admet-797	52	5	3.25	3.25	NUM
admet-797	52	6	,	,	PUNCT
admet-797	52	7	6.72	6.72	NUM
admet-797	52	8	,	,	PUNCT
admet-797	52	9	8.84	8.84	NUM
admet-797	53	1	[	[	X
admet-797	53	2	32	32	NUM
admet-797	53	3	]	]	X
admet-797	53	4	c	c	NOUN
admet-797	53	5	demeclocycline	demeclocycline	VERB
admet-797	53	6	465	465	NUM
admet-797	53	7	3.4	3.4	NUM
admet-797	53	8	,	,	PUNCT
admet-797	53	9	7.4	7.4	NUM
admet-797	53	10	,	,	PUNCT
admet-797	53	11	9.4	9.4	NUM
admet-797	53	12	-0.67	-0.67	NOUN
admet-797	54	1	[	[	X
admet-797	54	2	31	31	NUM
admet-797	54	3	]	]	SYM
admet-797	54	4	b	b	X
admet-797	54	5	doxycycline	doxycycline	NOUN
admet-797	54	6	444	444	NUM
admet-797	54	7	3.0	3.0	NUM
admet-797	54	8	,	,	PUNCT
admet-797	54	9	8.0	8.0	NUM
admet-797	54	10	,	,	PUNCT
admet-797	54	11	9.2	9.2	NUM
admet-797	54	12	-0.08	-0.08	NUM
admet-797	55	1	[	[	X
admet-797	55	2	31	31	NUM
admet-797	55	3	]	]	SYM
admet-797	55	4	b	b	PROPN
admet-797	55	5	3.50	3.50	NUM
admet-797	55	6	,	,	PUNCT
admet-797	55	7	7.25	7.25	NUM
admet-797	55	8	,	,	PUNCT
admet-797	55	9	9.58	9.58	NUM
admet-797	55	10	[	[	X
admet-797	55	11	32	32	NUM
admet-797	55	12	]	]	X
admet-797	55	13	c	c	PROPN
admet-797	55	14	minocycline	minocycline	PROPN
admet-797	55	15	457	457	NUM
admet-797	55	16	2.8	2.8	NUM
admet-797	55	17	,	,	PUNCT
admet-797	55	18	5.0	5.0	NUM
admet-797	55	19	,	,	PUNCT
admet-797	55	20	7.8	7.8	NUM
admet-797	55	21	,	,	PUNCT
admet-797	55	22	9.5	9.5	NUM
admet-797	55	23	0.20	0.20	NUM
admet-797	55	24	[	[	X
admet-797	55	25	33	33	NUM
admet-797	55	26	]	]	X
admet-797	55	27	d	d	X
admet-797	55	28	oxytetracycline	oxytetracycline	VERB
admet-797	55	29	460	460	NUM
admet-797	55	30	3.2	3.2	NUM
admet-797	55	31	,	,	PUNCT
admet-797	55	32	7.5	7.5	NUM
admet-797	55	33	,	,	PUNCT
admet-797	55	34	8.9	8.9	NUM
admet-797	55	35	-0.96	-0.96	NUM
admet-797	56	1	[	[	X
admet-797	56	2	31	31	NUM
admet-797	56	3	]	]	SYM
admet-797	56	4	b	b	PROPN
admet-797	56	5	3.53	3.53	NUM
admet-797	56	6	,	,	PUNCT
admet-797	56	7	7.25	7.25	NUM
admet-797	56	8	,	,	PUNCT
admet-797	56	9	9.58	9.58	NUM
admet-797	57	1	[	[	X
admet-797	57	2	32	32	NUM
admet-797	57	3	]	]	X
admet-797	57	4	c	c	PROPN
admet-797	57	5	tetracycline	tetracycline	PROPN
admet-797	57	6	444	444	NUM
admet-797	57	7	3.3	3.3	NUM
admet-797	57	8	,	,	PUNCT
admet-797	57	9	7.8	7.8	NUM
admet-797	57	10	,	,	PUNCT
admet-797	57	11	9.6	9.6	NUM
admet-797	57	12	-1.09	-1.09	NOUN
admet-797	58	1	[	[	X
admet-797	58	2	31	31	NUM
admet-797	58	3	]	]	SYM
admet-797	58	4	b	b	PROPN
admet-797	58	5	3.35	3.35	NUM
admet-797	58	6	,	,	PUNCT
admet-797	58	7	7.29	7.29	NUM
admet-797	58	8	,	,	PUNCT
admet-797	58	9	9.88	9.88	NUM
admet-797	59	1	[	[	X
admet-797	59	2	32	32	NUM
admet-797	59	3	]	]	X
admet-797	59	4	c	c	PROPN
admet-797	59	5	a	a	PRON
admet-797	59	6	measured	measure	VERB
admet-797	59	7	by	by	ADP
admet-797	59	8	a	a	DET
admet-797	59	9	shake	shake	NOUN
admet-797	59	10	-	-	PUNCT
admet-797	59	11	flask	flask	NOUN
admet-797	59	12	method	method	NOUN
admet-797	59	13	.	.	PUNCT
admet-797	60	1	ref	ref	NOUN
admet-797	60	2	.	.	PUNCT
admet-797	61	1	[	[	X
admet-797	61	2	30	30	NUM
admet-797	61	3	]	]	PUNCT
admet-797	61	4	.	.	PUNCT
admet-797	62	1	b	b	X
admet-797	62	2	potentiometry	potentiometry	NOUN
admet-797	62	3	(	(	PUNCT
admet-797	62	4	23	23	NUM
admet-797	62	5	°	°	NOUN
admet-797	62	6	c	c	NOUN
admet-797	62	7	)	)	PUNCT
admet-797	62	8	,	,	PUNCT
admet-797	62	9	ionic	ionic	ADJ
admet-797	62	10	strength	strength	NOUN
admet-797	62	11	=	=	NOUN
admet-797	62	12	0.01	0.01	NUM
admet-797	62	13	or	or	CCONJ
admet-797	62	14	0.05	0.05	NUM
admet-797	62	15	m.	m.	NOUN
admet-797	62	16	c	c	PROPN
admet-797	62	17	potentiometry	potentiometry	NOUN
admet-797	62	18	(	(	PUNCT
admet-797	62	19	25	25	NUM
admet-797	62	20	°	°	NOUN
admet-797	62	21	c	c	NOUN
admet-797	62	22	)	)	PUNCT
admet-797	62	23	,	,	PUNCT
admet-797	62	24	ionic	ionic	ADJ
admet-797	62	25	strength	strength	NOUN
admet-797	62	26	=	=	SYM
admet-797	62	27	0.1	0.1	NUM
admet-797	62	28	m.	m.	NOUN
admet-797	62	29	d	d	NOUN
admet-797	62	30	method	method	NOUN
admet-797	62	31	not	not	PART
admet-797	62	32	described	describe	VERB
admet-797	62	33	in	in	ADP
admet-797	62	34	the	the	DET
admet-797	62	35	literature	literature	NOUN
admet-797	62	36	.	.	PUNCT
admet-797	63	1	pampa	pampa	PROPN
admet-797	63	2	assay	assay	VERB
admet-797	63	3	the	the	DET
admet-797	63	4	pampa	pampa	PROPN
admet-797	63	5	sandwich	sandwich	NOUN
admet-797	63	6	was	be	AUX
admet-797	63	7	consisted	consist	VERB
admet-797	63	8	of	of	ADP
admet-797	63	9	a	a	DET
admet-797	63	10	96	96	NUM
admet-797	63	11	well	well	NOUN
admet-797	63	12	filter	filter	NOUN
admet-797	63	13	plate	plate	NOUN
admet-797	63	14	(	(	PUNCT
admet-797	63	15	hydrophobic	hydrophobic	NOUN
admet-797	63	16	pvdf	pvdf	PROPN
admet-797	63	17	,	,	PUNCT
admet-797	63	18	0.45	0.45	NUM
admet-797	63	19	μm	μm	NOUN
admet-797	63	20	)	)	PUNCT
admet-797	63	21	and	and	CCONJ
admet-797	63	22	a	a	DET
admet-797	63	23	pampa	pampa	NOUN
admet-797	63	24	acceptor	acceptor	NOUN
admet-797	63	25	plate	plate	NOUN
admet-797	63	26	(	(	PUNCT
admet-797	63	27	merck	merck	PROPN
admet-797	63	28	millipore	millipore	PROPN
admet-797	63	29	,	,	PUNCT
admet-797	63	30	ma	ma	PROPN
admet-797	63	31	,	,	PUNCT
admet-797	63	32	usa	usa	PROPN
admet-797	63	33	)	)	PUNCT
admet-797	63	34	.	.	PUNCT
admet-797	64	1	before	before	ADP
admet-797	64	2	forming	form	VERB
admet-797	64	3	the	the	DET
admet-797	64	4	pampa	pampa	NOUN
admet-797	64	5	sandwich	sandwich	NOUN
admet-797	64	6	,	,	PUNCT
admet-797	64	7	the	the	DET
admet-797	64	8	bottom	bottom	NOUN
admet-797	64	9	(	(	PUNCT
admet-797	64	10	acceptor	acceptor	NOUN
admet-797	64	11	)	)	PUNCT
admet-797	64	12	plate	plate	NOUN
admet-797	64	13	was	be	AUX
admet-797	64	14	filled	fill	VERB
admet-797	64	15	with	with	ADP
admet-797	64	16	300	300	NUM
admet-797	64	17	μl	μl	ADP
admet-797	64	18	of	of	ADP
admet-797	64	19	a	a	DET
admet-797	64	20	50	50	NUM
admet-797	64	21	mm	mm	NOUN
admet-797	64	22	mes	me	NOUN
admet-797	64	23	buffer	buffer	NOUN
admet-797	64	24	(	(	PUNCT
admet-797	64	25	ph	ph	NOUN
admet-797	64	26	6.5	6.5	NUM
admet-797	64	27	)	)	PUNCT
admet-797	64	28	.	.	PUNCT
admet-797	65	1	the	the	DET
admet-797	65	2	filter	filter	NOUN
admet-797	65	3	of	of	ADP
admet-797	65	4	the	the	DET
admet-797	65	5	top	top	ADJ
admet-797	65	6	(	(	PUNCT
admet-797	65	7	donor	donor	NOUN
admet-797	65	8	)	)	PUNCT
admet-797	65	9	compartment	compartment	NOUN
admet-797	65	10	was	be	AUX
admet-797	65	11	coated	coat	VERB
admet-797	65	12	with	with	ADP
admet-797	65	13	5	5	NUM
admet-797	65	14	μl	μl	ADP
admet-797	65	15	of	of	ADP
admet-797	65	16	a	a	DET
admet-797	65	17	10	10	NUM
admet-797	65	18	%	%	NOUN
admet-797	65	19	soybean	soybean	NOUN
admet-797	65	20	lecithin	lecithin	NOUN
admet-797	65	21	(	(	PUNCT
admet-797	65	22	sl	sl	NOUN
admet-797	65	23	)	)	PUNCT
admet-797	65	24	–	–	PUNCT
admet-797	65	25	decane	decane	NOUN
admet-797	65	26	solution	solution	NOUN
admet-797	65	27	or	or	CCONJ
admet-797	65	28	octanol	octanol	NOUN
admet-797	65	29	.	.	PUNCT
admet-797	66	1	a	a	DET
admet-797	66	2	drug	drug	NOUN
admet-797	66	3	solution	solution	NOUN
admet-797	66	4	(	(	PUNCT
admet-797	66	5	0.5	0.5	NUM
admet-797	66	6	mm	mm	NOUN
admet-797	66	7	,	,	PUNCT
admet-797	66	8	200	200	NUM
admet-797	66	9	μl	μl	NUM
admet-797	66	10	)	)	PUNCT
admet-797	66	11	with	with	ADP
admet-797	66	12	or	or	CCONJ
admet-797	66	13	without	without	ADP
admet-797	66	14	a	a	DET
admet-797	66	15	divalent	divalent	ADJ
admet-797	66	16	metal	metal	NOUN
admet-797	66	17	ion	ion	NOUN
admet-797	66	18	(	(	PUNCT
admet-797	66	19	5	5	NUM
admet-797	66	20	mm	mm	NOUN
admet-797	66	21	)	)	PUNCT
admet-797	66	22	and/or	and/or	CCONJ
admet-797	66	23	mucin	mucin	NOUN
admet-797	66	24	(	(	PUNCT
admet-797	66	25	1	1	NUM
admet-797	66	26	%	%	NOUN
admet-797	66	27	)	)	PUNCT
admet-797	66	28	in	in	ADP
admet-797	66	29	the	the	DET
admet-797	66	30	same	same	ADJ
admet-797	66	31	buffer	buffer	NOUN
admet-797	66	32	was	be	AUX
admet-797	66	33	added	add	VERB
admet-797	66	34	to	to	ADP
admet-797	66	35	the	the	DET
admet-797	66	36	donor	donor	NOUN
admet-797	66	37	compartment	compartment	NOUN
admet-797	66	38	.	.	PUNCT
admet-797	67	1	the	the	DET
admet-797	67	2	pampa	pampa	PROPN
admet-797	67	3	sandwich	sandwich	NOUN
admet-797	67	4	was	be	AUX
admet-797	67	5	then	then	ADV
admet-797	67	6	incubated	incubate	VERB
admet-797	67	7	for	for	ADP
admet-797	67	8	3	3	NUM
admet-797	67	9	h	h	NOUN
admet-797	67	10	at	at	ADP
admet-797	67	11	37	37	NUM
admet-797	67	12	°	°	NOUN
admet-797	67	13	c	c	NOUN
admet-797	67	14	.	.	PUNCT
admet-797	68	1	after	after	ADP
admet-797	68	2	incubation	incubation	NOUN
admet-797	68	3	,	,	PUNCT
admet-797	68	4	150	150	NUM
admet-797	68	5	μl	μl	PRON
admet-797	68	6	of	of	ADP
admet-797	68	7	both	both	CCONJ
admet-797	68	8	the	the	DET
admet-797	68	9	donor	donor	NOUN
admet-797	68	10	and	and	CCONJ
admet-797	68	11	acceptor	acceptor	NOUN
admet-797	68	12	solutions	solution	NOUN
admet-797	68	13	were	be	AUX
admet-797	68	14	transferred	transfer	VERB
admet-797	68	15	to	to	ADP
admet-797	68	16	a	a	DET
admet-797	68	17	uv	uv	NOUN
admet-797	68	18	plate	plate	NOUN
admet-797	68	19	.	.	PUNCT
admet-797	69	1	the	the	DET
admet-797	69	2	concentrations	concentration	NOUN
admet-797	69	3	of	of	ADP
admet-797	69	4	tetracyclines	tetracycline	NOUN
admet-797	69	5	were	be	AUX
admet-797	69	6	measured	measure	VERB
admet-797	69	7	at	at	ADP
admet-797	69	8	360	360	NUM
admet-797	69	9	nm	nm	NOUN
admet-797	69	10	.	.	PUNCT
admet-797	70	1	the	the	DET
admet-797	70	2	pampa	pampa	PROPN
admet-797	70	3	permeability	permeability	NOUN
admet-797	70	4	(	(	PUNCT
admet-797	70	5	pe	pe	INTJ
admet-797	70	6	)	)	PUNCT
admet-797	70	7	was	be	AUX
admet-797	70	8	calculated	calculate	VERB
admet-797	70	9	by	by	ADP
admet-797	70	10	the	the	DET
admet-797	70	11	following	follow	VERB
admet-797	70	12	equation	equation	NOUN
admet-797	70	13	[	[	X
admet-797	70	14	34	34	NUM
admet-797	70	15	]	]	PUNCT
admet-797	70	16	.	.	PUNCT
admet-797	71	1	d	d	X
admet-797	71	2	v	v	X
admet-797	71	3	d	d	X
admet-797	71	4	e	e	NOUN
admet-797	71	5	v	v	ADP
admet-797	71	6	v	v	NUM
admet-797	71	7	d	d	PROPN
admet-797	71	8	2.303	2.303	NUM
admet-797	71	9	1	1	NUM
admet-797	71	10	(	(	PUNCT
admet-797	71	11	)	)	PUNCT
admet-797	71	12	1	1	NUM
admet-797	71	13	log	log	VERB
admet-797	71	14	1	1	NUM
admet-797	71	15	1	1	NUM
admet-797	71	16	(	(	PUNCT
admet-797	71	17	0	0	NUM
admet-797	71	18	)	)	PUNCT
admet-797	71	19	v	v	NOUN
admet-797	71	20	r	r	NOUN
admet-797	71	21	c	c	NOUN
admet-797	71	22	t	t	NOUN
admet-797	71	23	p	p	NOUN
admet-797	71	24	r	r	NOUN
admet-797	71	25	at	at	ADP
admet-797	71	26	r	r	NOUN
admet-797	71	27	r	r	NOUN
admet-797	71	28	c	c	NOUN
admet-797	71	29			NOUN
admet-797	71	30			NOUN
admet-797	71	31			NOUN
admet-797	71	32			PROPN
admet-797	71	33			PROPN
admet-797	71	34			PROPN
admet-797	71	35			PROPN
admet-797	71	36			PROPN
admet-797	71	37			PROPN
admet-797	71	38			PROPN
admet-797	71	39			PROPN
admet-797	71	40			NOUN
admet-797	72	1			PROPN
admet-797	72	2			ADV
admet-797	72	3			NOUN
admet-797	72	4			PRON
admet-797	72	5			NOUN
admet-797	72	6			PROPN
admet-797	72	7			NOUN
admet-797	72	8	(	(	PUNCT
admet-797	72	9	1	1	NUM
admet-797	72	10	)	)	PUNCT
admet-797	72	11	d	d	NOUN
admet-797	72	12	a	a	PRON
admet-797	72	13	d	d	X
admet-797	72	14	v	v	X
admet-797	72	15	d	d	PROPN
admet-797	72	16	(	(	PUNCT
admet-797	72	17	)	)	PUNCT
admet-797	72	18	(	(	PUNCT
admet-797	72	19	)	)	SYM
admet-797	72	20	1	1	NUM
admet-797	72	21	1	1	NUM
admet-797	72	22	(	(	PUNCT
admet-797	72	23	0	0	NUM
admet-797	72	24	)	)	PUNCT
admet-797	72	25	(	(	PUNCT
admet-797	72	26	0	0	NUM
admet-797	72	27	)	)	PUNCT
admet-797	73	1	c	c	NOUN
admet-797	74	1	t	t	PROPN
admet-797	74	2	c	c	NOUN
admet-797	74	3	t	t	NOUN
admet-797	74	4	r	r	NOUN
admet-797	75	1	c	c	NOUN
admet-797	75	2	r	r	NOUN
admet-797	75	3	c	c	NOUN
admet-797	75	4			PROPN
admet-797	75	5			PROPN
admet-797	75	6			NOUN
admet-797	75	7	(	(	PUNCT
admet-797	75	8	2	2	NUM
admet-797	75	9	)	)	PUNCT
admet-797	75	10	d	d	NOUN
admet-797	75	11	v	v	ADP
admet-797	75	12	a	a	DET
admet-797	75	13	v	v	NOUN
admet-797	75	14	r	r	NOUN
admet-797	75	15	v	v	NOUN
admet-797	75	16			NOUN
admet-797	75	17	(	(	PUNCT
admet-797	75	18	3	3	NUM
admet-797	75	19	)	)	PUNCT
admet-797	75	20	where	where	SCONJ
admet-797	75	21	pe	pe	PROPN
admet-797	75	22	is	be	AUX
admet-797	75	23	the	the	DET
admet-797	75	24	effective	effective	ADJ
admet-797	75	25	permeation	permeation	NOUN
admet-797	75	26	coefficient	coefficient	NOUN
admet-797	75	27	(	(	PUNCT
admet-797	75	28	cm	cm	NOUN
admet-797	75	29	/	/	SYM
admet-797	75	30	s	s	NOUN
admet-797	75	31	)	)	PUNCT
admet-797	75	32	,	,	PUNCT
admet-797	75	33	a	a	PRON
admet-797	75	34	is	be	AUX
admet-797	75	35	the	the	DET
admet-797	75	36	filter	filter	NOUN
admet-797	75	37	surface	surface	NOUN
admet-797	75	38	area	area	NOUN
admet-797	75	39	(	(	PUNCT
admet-797	75	40	0.266	0.266	NUM
admet-797	75	41	cm2	cm2	NOUN
admet-797	75	42	)	)	PUNCT
admet-797	75	43	,	,	PUNCT
admet-797	75	44	vd	vd	NOUN
admet-797	75	45	and	and	CCONJ
admet-797	75	46	va	va	PROPN
admet-797	75	47	are	be	AUX
admet-797	75	48	the	the	DET
admet-797	75	49	volumes	volume	NOUN
admet-797	75	50	(	(	PUNCT
admet-797	75	51	ml	ml	NOUN
admet-797	75	52	)	)	PUNCT
admet-797	75	53	in	in	ADP
admet-797	75	54	the	the	DET
admet-797	75	55	donor	donor	NOUN
admet-797	75	56	and	and	CCONJ
admet-797	75	57	acceptor	acceptor	NOUN
admet-797	75	58	phase	phase	NOUN
admet-797	75	59	,	,	PUNCT
admet-797	75	60	t	t	PROPN
admet-797	75	61	is	be	AUX
admet-797	75	62	the	the	DET
admet-797	75	63	incubation	incubation	NOUN
admet-797	75	64	time	time	NOUN
admet-797	75	65	,	,	PUNCT
admet-797	75	66	cd(t	cd(t	PUNCT
admet-797	75	67	)	)	PUNCT
admet-797	75	68	is	be	AUX
admet-797	75	69	the	the	DET
admet-797	75	70	concentration	concentration	NOUN
admet-797	75	71	of	of	ADP
admet-797	75	72	a	a	DET
admet-797	75	73	drug	drug	NOUN
admet-797	75	74	in	in	ADP
admet-797	75	75	the	the	DET
admet-797	75	76	donor	donor	NOUN
admet-797	75	77	phase	phase	NOUN
admet-797	75	78	at	at	ADP
admet-797	75	79	time	time	NOUN
admet-797	75	80	t	t	PROPN
admet-797	75	81	,	,	PUNCT
admet-797	75	82	r	r	NOUN
admet-797	75	83	is	be	AUX
admet-797	75	84	the	the	DET
admet-797	75	85	membrane	membrane	NOUN
admet-797	75	86	retention	retention	NOUN
admet-797	75	87	factor	factor	NOUN
admet-797	75	88	,	,	PUNCT
admet-797	75	89	and	and	CCONJ
admet-797	75	90	rv	rv	PROPN
admet-797	75	91	is	be	AUX
admet-797	75	92	the	the	DET
admet-797	75	93	volume	volume	NOUN
admet-797	75	94	ratio	ratio	NOUN
admet-797	75	95	.	.	PUNCT
admet-797	76	1	we	we	PRON
admet-797	76	2	confirmed	confirm	VERB
admet-797	76	3	that	that	SCONJ
admet-797	76	4	the	the	DET
admet-797	76	5	phospholipid	phospholipid	NOUN
admet-797	76	6	decane	decane	NOUN
admet-797	76	7	membrane	membrane	NOUN
admet-797	76	8	is	be	AUX
admet-797	76	9	stable	stable	ADJ
admet-797	76	10	during	during	ADP
admet-797	76	11	the	the	DET
admet-797	76	12	experimental	experimental	ADJ
admet-797	76	13	period	period	NOUN
admet-797	76	14	(	(	PUNCT
admet-797	76	15	no	no	DET
admet-797	76	16	leakage	leakage	NOUN
admet-797	76	17	of	of	ADP
admet-797	76	18	impermeable	impermeable	ADJ
admet-797	76	19	substrate	substrate	NOUN
admet-797	76	20	)	)	PUNCT
admet-797	76	21	(	(	PUNCT
admet-797	76	22	data	datum	NOUN
admet-797	76	23	not	not	PART
admet-797	76	24	shown	show	VERB
admet-797	76	25	)	)	PUNCT
admet-797	76	26	.	.	PUNCT
admet-797	77	1	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	77	2	kiyohiko	kiyohiko	PROPN
admet-797	77	3	sugano	sugano	PROPN
admet-797	77	4	et	et	PROPN
admet-797	77	5	al	al	PROPN
admet-797	77	6	.	.	PROPN
admet-797	77	7	admet	admet	PROPN
admet-797	77	8	&	&	CCONJ
admet-797	77	9	dmpk	dmpk	PROPN
admet-797	77	10	8(2	8(2	NUM
admet-797	77	11	)	)	PUNCT
admet-797	77	12	(	(	PUNCT
admet-797	77	13	2020	2020	NUM
admet-797	77	14	)	)	PUNCT
admet-797	77	15	129	129	NUM
admet-797	77	16	-	-	SYM
admet-797	77	17	138	138	NUM
admet-797	77	18	132	132	NUM
admet-797	77	19	results	result	NOUN
admet-797	77	20	and	and	CCONJ
admet-797	77	21	discussion	discussion	NOUN
admet-797	77	22	previously	previously	ADV
admet-797	77	23	,	,	PUNCT
admet-797	77	24	we	we	PRON
admet-797	77	25	reported	report	VERB
admet-797	77	26	that	that	SCONJ
admet-797	77	27	the	the	DET
admet-797	77	28	pe	pe	PROPN
admet-797	77	29	value	value	NOUN
admet-797	77	30	of	of	ADP
admet-797	77	31	tc	tc	PRON
admet-797	77	32	was	be	AUX
admet-797	77	33	markedly	markedly	ADV
admet-797	77	34	affected	affect	VERB
admet-797	77	35	by	by	ADP
admet-797	77	36	the	the	DET
admet-797	77	37	composition	composition	NOUN
admet-797	77	38	of	of	ADP
admet-797	77	39	phospholipids	phospholipid	NOUN
admet-797	77	40	in	in	ADP
admet-797	77	41	pampa	pampa	PROPN
admet-797	77	42	[	[	X
admet-797	77	43	30	30	NUM
admet-797	77	44	]	]	PUNCT
admet-797	77	45	.	.	PUNCT
admet-797	78	1	in	in	ADP
admet-797	78	2	this	this	DET
admet-797	78	3	study	study	NOUN
admet-797	78	4	,	,	PUNCT
admet-797	78	5	a	a	DET
admet-797	78	6	soybean	soybean	NOUN
admet-797	78	7	lecithin	lecithin	NOUN
admet-797	78	8	(	(	PUNCT
admet-797	78	9	sl	sl	INTJ
admet-797	78	10	,	,	PUNCT
admet-797	78	11	10	10	NUM
admet-797	78	12	%	%	NOUN
admet-797	78	13	)	)	PUNCT
admet-797	78	14	–	–	PUNCT
admet-797	78	15	decane	decane	NOUN
admet-797	78	16	membrane	membrane	NOUN
admet-797	78	17	(	(	PUNCT
admet-797	78	18	sl	sl	INTJ
admet-797	78	19	–	–	PUNCT
admet-797	78	20	pampa	pampa	PROPN
admet-797	78	21	)	)	PUNCT
admet-797	78	22	was	be	AUX
admet-797	78	23	used	use	VERB
admet-797	78	24	because	because	SCONJ
admet-797	78	25	it	it	PRON
admet-797	78	26	most	most	ADV
admet-797	78	27	likely	likely	ADV
admet-797	78	28	mimics	mimic	VERB
admet-797	78	29	the	the	DET
admet-797	78	30	intestinal	intestinal	ADJ
admet-797	78	31	membrane	membrane	NOUN
admet-797	79	1	[	[	X
admet-797	79	2	34	34	NUM
admet-797	79	3	]	]	PUNCT
admet-797	79	4	.	.	PUNCT
admet-797	80	1	the	the	DET
admet-797	80	2	soybean	soybean	NOUN
admet-797	80	3	lecithin	lecithin	NOUN
admet-797	80	4	contained	contain	VERB
admet-797	80	5	phosphatidylcholine	phosphatidylcholine	NOUN
admet-797	80	6	(	(	PUNCT
admet-797	80	7	24	24	NUM
admet-797	80	8	-	-	SYM
admet-797	80	9	32	32	NUM
admet-797	80	10	%	%	NOUN
admet-797	80	11	)	)	PUNCT
admet-797	80	12	,	,	PUNCT
admet-797	80	13	phosphatidylethanolamine	phosphatidylethanolamine	NOUN
admet-797	80	14	(	(	PUNCT
admet-797	80	15	20	20	NUM
admet-797	80	16	-	-	SYM
admet-797	80	17	28	28	NUM
admet-797	80	18	%	%	NOUN
admet-797	80	19	)	)	PUNCT
admet-797	80	20	,	,	PUNCT
admet-797	80	21	phosphatidylinositol	phosphatidylinositol	NOUN
admet-797	80	22	(	(	PUNCT
admet-797	80	23	12	12	NUM
admet-797	80	24	-	-	SYM
admet-797	80	25	20	20	NUM
admet-797	80	26	%	%	NOUN
admet-797	80	27	)	)	PUNCT
admet-797	80	28	,	,	PUNCT
admet-797	80	29	phosphatidic	phosphatidic	ADJ
admet-797	80	30	acid	acid	NOUN
admet-797	80	31	(	(	PUNCT
admet-797	80	32	8	8	NUM
admet-797	80	33	-	-	SYM
admet-797	80	34	15	15	NUM
admet-797	80	35	%	%	NOUN
admet-797	80	36	)	)	PUNCT
admet-797	80	37	,	,	PUNCT
admet-797	80	38	and	and	CCONJ
admet-797	80	39	lysophosphatidylcholines	lysophosphatidylcholine	NOUN
admet-797	80	40	(	(	PUNCT
admet-797	80	41	1–5	1–5	NUM
admet-797	80	42	%	%	NOUN
admet-797	80	43	)	)	PUNCT
admet-797	80	44	(	(	PUNCT
admet-797	80	45	based	base	VERB
admet-797	80	46	on	on	ADP
admet-797	80	47	the	the	DET
admet-797	80	48	product	product	NOUN
admet-797	80	49	information	information	NOUN
admet-797	80	50	provided	provide	VERB
admet-797	80	51	by	by	ADP
admet-797	80	52	the	the	DET
admet-797	80	53	manufacturer	manufacturer	NOUN
admet-797	80	54	)	)	PUNCT
admet-797	80	55	.	.	PUNCT
admet-797	81	1	in	in	ADP
admet-797	81	2	addition	addition	NOUN
admet-797	81	3	,	,	PUNCT
admet-797	81	4	an	an	DET
admet-797	81	5	octanol	octanol	NOUN
admet-797	81	6	membrane	membrane	NOUN
admet-797	81	7	(	(	PUNCT
admet-797	81	8	oct	oct	NOUN
admet-797	81	9	–	–	PUNCT
admet-797	81	10	pampa	pampa	NOUN
admet-797	81	11	)	)	PUNCT
admet-797	82	1	[	[	X
admet-797	82	2	35,36	35,36	NUM
admet-797	82	3	]	]	PUNCT
admet-797	82	4	was	be	AUX
admet-797	82	5	also	also	ADV
admet-797	82	6	used	use	VERB
admet-797	82	7	because	because	SCONJ
admet-797	82	8	ca	ca	PROPN
admet-797	82	9	2	2	NUM
admet-797	82	10	+	+	CCONJ
admet-797	82	11	was	be	AUX
admet-797	82	12	reported	report	VERB
admet-797	82	13	to	to	PART
admet-797	82	14	increase	increase	VERB
admet-797	82	15	the	the	DET
admet-797	82	16	log	log	NOUN
admet-797	82	17	doct	doct	NOUN
admet-797	82	18	of	of	ADP
admet-797	82	19	tc	tc	NOUN
admet-797	83	1	[	[	X
admet-797	83	2	23	23	NUM
admet-797	83	3	]	]	PUNCT
admet-797	83	4	.	.	PUNCT
admet-797	84	1	since	since	SCONJ
admet-797	84	2	ca	ca	NOUN
admet-797	84	3	2	2	NUM
admet-797	84	4	+	+	NUM
admet-797	84	5	interacts	interact	VERB
admet-797	84	6	with	with	ADP
admet-797	84	7	phosphate	phosphate	ADJ
admet-797	84	8	and	and	CCONJ
admet-797	84	9	citrate	citrate	NOUN
admet-797	84	10	ions	ion	NOUN
admet-797	84	11	,	,	PUNCT
admet-797	84	12	mes	me	NOUN
admet-797	84	13	buffer	buffer	NOUN
admet-797	84	14	was	be	AUX
admet-797	84	15	used	use	VERB
admet-797	84	16	in	in	ADP
admet-797	84	17	this	this	DET
admet-797	84	18	study	study	NOUN
admet-797	84	19	.	.	PUNCT
admet-797	85	1	the	the	DET
admet-797	85	2	concentration	concentration	NOUN
admet-797	85	3	of	of	ADP
admet-797	85	4	ca	ca	NOUN
admet-797	85	5	2	2	NUM
admet-797	85	6	+	+	CCONJ
admet-797	85	7	was	be	AUX
admet-797	85	8	set	set	VERB
admet-797	85	9	to	to	ADP
admet-797	85	10	5	5	NUM
admet-797	85	11	mm	mm	NOUN
admet-797	85	12	based	base	VERB
admet-797	85	13	on	on	ADP
admet-797	85	14	the	the	DET
admet-797	85	15	standard	standard	NOUN
admet-797	85	16	of	of	ADP
admet-797	85	17	the	the	DET
admet-797	85	18	daily	daily	PROPN
admet-797	85	19	intake	intake	NOUN
admet-797	85	20	in	in	ADP
admet-797	85	21	food	food	NOUN
admet-797	85	22	(	(	PUNCT
admet-797	85	23	600	600	NUM
admet-797	85	24	mg	mg	NOUN
admet-797	85	25	)	)	PUNCT
admet-797	86	1	[	[	X
admet-797	86	2	37	37	NUM
admet-797	86	3	]	]	PUNCT
admet-797	86	4	and	and	CCONJ
admet-797	86	5	the	the	DET
admet-797	86	6	gastrointestinal	gastrointestinal	ADJ
admet-797	86	7	fluid	fluid	NOUN
admet-797	86	8	volume	volume	NOUN
admet-797	86	9	in	in	ADP
admet-797	86	10	the	the	DET
admet-797	86	11	fed	fed	PROPN
admet-797	86	12	state	state	NOUN
admet-797	87	1	[	[	X
admet-797	87	2	38	38	NUM
admet-797	87	3	]	]	PUNCT
admet-797	87	4	.	.	PUNCT
admet-797	88	1	we	we	PRON
admet-797	88	2	previously	previously	ADV
admet-797	88	3	reported	report	VERB
admet-797	88	4	that	that	SCONJ
admet-797	88	5	the	the	DET
admet-797	88	6	pe	pe	PROPN
admet-797	88	7	value	value	NOUN
admet-797	88	8	of	of	ADP
admet-797	88	9	tc	tc	NOUN
admet-797	88	10	in	in	ADP
admet-797	88	11	sl	sl	NOUN
admet-797	88	12	-	-	PUNCT
admet-797	88	13	pampa	pampa	NOUN
admet-797	88	14	was	be	AUX
admet-797	88	15	not	not	PART
admet-797	88	16	affected	affect	VERB
admet-797	88	17	by	by	ADP
admet-797	88	18	the	the	DET
admet-797	88	19	ionic	ionic	ADJ
admet-797	88	20	strength	strength	NOUN
admet-797	88	21	up	up	ADP
admet-797	88	22	to	to	PART
admet-797	88	23	2	2	NUM
admet-797	88	24	mol	mol	NOUN
admet-797	88	25	/	/	SYM
admet-797	88	26	l	l	NOUN
admet-797	88	27	(	(	PUNCT
admet-797	88	28	adjusted	adjust	VERB
admet-797	88	29	by	by	ADP
admet-797	88	30	nacl	nacl	NOUN
admet-797	88	31	)	)	PUNCT
admet-797	89	1	[	[	X
admet-797	89	2	34	34	NUM
admet-797	89	3	]	]	PUNCT
admet-797	89	4	.	.	PUNCT
admet-797	90	1	in	in	ADP
admet-797	90	2	sl	sl	PROPN
admet-797	90	3	–	–	PUNCT
admet-797	90	4	pampa	pampa	NOUN
admet-797	90	5	,	,	PUNCT
admet-797	90	6	ca	ca	NOUN
admet-797	90	7	2	2	NUM
admet-797	90	8	+	+	NUM
admet-797	90	9	and	and	CCONJ
admet-797	90	10	mg	mg	PROPN
admet-797	90	11	2	2	NUM
admet-797	90	12	+	+	CCONJ
admet-797	90	13	markedly	markedly	ADV
admet-797	90	14	decreased	decrease	VERB
admet-797	90	15	the	the	DET
admet-797	90	16	pe	pe	PROPN
admet-797	90	17	values	value	NOUN
admet-797	90	18	of	of	ADP
admet-797	90	19	all	all	DET
admet-797	90	20	tetracyclines	tetracycline	NOUN
admet-797	90	21	investigated	investigate	VERB
admet-797	90	22	in	in	ADP
admet-797	90	23	this	this	DET
admet-797	90	24	study	study	NOUN
admet-797	90	25	,	,	PUNCT
admet-797	90	26	whereas	whereas	SCONJ
admet-797	90	27	mucin	mucin	NOUN
admet-797	90	28	showed	show	VERB
admet-797	90	29	little	little	ADJ
admet-797	90	30	or	or	CCONJ
admet-797	90	31	no	no	PRON
admet-797	90	32	effect	effect	NOUN
admet-797	90	33	(	(	PUNCT
admet-797	90	34	figure	figure	NOUN
admet-797	90	35	2	2	NUM
admet-797	90	36	)	)	PUNCT
admet-797	90	37	.	.	PUNCT
admet-797	91	1	these	these	DET
admet-797	91	2	results	result	NOUN
admet-797	91	3	suggest	suggest	VERB
admet-797	91	4	that	that	SCONJ
admet-797	91	5	,	,	PUNCT
admet-797	91	6	in	in	ADP
admet-797	91	7	contrast	contrast	NOUN
admet-797	91	8	to	to	ADP
admet-797	91	9	the	the	DET
admet-797	91	10	previous	previous	ADJ
admet-797	91	11	suggestion	suggestion	NOUN
admet-797	91	12	based	base	VERB
admet-797	91	13	on	on	ADP
admet-797	91	14	the	the	DET
admet-797	91	15	alcohol	alcohol	NOUN
admet-797	91	16	–	–	PUNCT
admet-797	91	17	water	water	NOUN
admet-797	91	18	partition	partition	NOUN
admet-797	91	19	coefficient	coefficient	NOUN
admet-797	92	1	[	[	X
admet-797	92	2	21–23	21–23	NUM
admet-797	92	3	]	]	X
admet-797	92	4	,	,	PUNCT
admet-797	92	5	ca2	ca2	PROPN
admet-797	92	6	+	+	CCONJ
admet-797	92	7	chelate	chelate	NOUN
admet-797	92	8	formation	formation	NOUN
admet-797	92	9	decrease	decrease	VERB
admet-797	92	10	the	the	DET
admet-797	92	11	membrane	membrane	NOUN
admet-797	92	12	permeation	permeation	NOUN
admet-797	92	13	of	of	ADP
admet-797	92	14	tetracyclines	tetracycline	NOUN
admet-797	92	15	,	,	PUNCT
admet-797	92	16	irrespective	irrespective	ADV
admet-797	92	17	of	of	ADP
admet-797	92	18	ca2	ca2	PROPN
admet-797	92	19	+	+	PROPN
admet-797	92	20	linked	link	VERB
admet-797	92	21	mucin	mucin	NOUN
admet-797	92	22	binding	bind	VERB
admet-797	92	23	.	.	PUNCT
admet-797	93	1	figure	figure	NOUN
admet-797	93	2	2	2	NUM
admet-797	93	3	.	.	PUNCT
admet-797	93	4	effect	effect	NOUN
admet-797	93	5	of	of	ADP
admet-797	93	6	additives	additive	NOUN
admet-797	93	7	on	on	ADP
admet-797	93	8	sl	sl	PROPN
admet-797	93	9	–	–	PUNCT
admet-797	93	10	pampa	pampa	NOUN
admet-797	93	11	permeation	permeation	NOUN
admet-797	93	12	of	of	ADP
admet-797	93	13	tetracyclines	tetracycline	NOUN
admet-797	93	14	(	(	PUNCT
admet-797	93	15	mean	mean	PROPN
admet-797	93	16	±	±	NUM
admet-797	93	17	sd	sd	NOUN
admet-797	93	18	,	,	PUNCT
admet-797	93	19	n	n	NOUN
admet-797	93	20	=	=	SYM
admet-797	93	21	3	3	NUM
admet-797	93	22	6	6	NUM
admet-797	93	23	)	)	PUNCT
admet-797	93	24	.	.	PUNCT
admet-797	94	1	molecular	molecular	ADJ
admet-797	94	2	speciation	speciation	NOUN
admet-797	94	3	analysis	analysis	NOUN
admet-797	94	4	was	be	AUX
admet-797	94	5	performed	perform	VERB
admet-797	94	6	to	to	PART
admet-797	94	7	elucidate	elucidate	VERB
admet-797	94	8	the	the	DET
admet-797	94	9	effect	effect	NOUN
admet-797	94	10	of	of	ADP
admet-797	94	11	ca2	ca2	PROPN
admet-797	94	12	+	+	PROPN
admet-797	94	13	and	and	CCONJ
admet-797	94	14	mg2	mg2	PROPN
admet-797	94	15	+	+	X
admet-797	94	16	on	on	ADP
admet-797	94	17	the	the	DET
admet-797	94	18	slpampa	slpampa	PROPN
admet-797	94	19	permeation	permeation	NOUN
admet-797	94	20	of	of	ADP
admet-797	94	21	tetracyclines	tetracyclines	PROPN
admet-797	94	22	.	.	PUNCT
admet-797	95	1	the	the	DET
admet-797	95	2	details	detail	NOUN
admet-797	95	3	of	of	ADP
admet-797	95	4	molecular	molecular	ADJ
admet-797	95	5	speciation	speciation	NOUN
admet-797	95	6	analysis	analysis	NOUN
admet-797	95	7	have	have	AUX
admet-797	95	8	been	be	AUX
admet-797	95	9	reported	report	VERB
admet-797	95	10	by	by	ADP
admet-797	95	11	werner	werner	PROPN
admet-797	95	12	et	et	PROPN
admet-797	95	13	al	al	PROPN
admet-797	96	1	[	[	X
admet-797	96	2	39	39	NUM
admet-797	96	3	]	]	PUNCT
admet-797	96	4	.	.	PUNCT
admet-797	97	1	tetracyclines	tetracycline	NOUN
admet-797	97	2	and	and	CCONJ
admet-797	97	3	divalent	divalent	ADJ
admet-797	97	4	metal	metal	NOUN
admet-797	97	5	ions	ion	NOUN
admet-797	97	6	can	can	AUX
admet-797	97	7	form	form	VERB
admet-797	97	8	a	a	DET
admet-797	97	9	chelate	chelate	NOUN
admet-797	97	10	with	with	ADP
admet-797	97	11	various	various	ADJ
admet-797	97	12	stoichiometries	stoichiometry	NOUN
admet-797	97	13	(	(	PUNCT
admet-797	97	14	2:1	2:1	NUM
admet-797	97	15	,	,	PUNCT
admet-797	97	16	1:1	1:1	NUM
admet-797	97	17	,	,	PUNCT
admet-797	97	18	1:2	1:2	NUM
admet-797	97	19	)	)	PUNCT
admet-797	97	20	,	,	PUNCT
admet-797	97	21	depending	depend	VERB
admet-797	97	22	on	on	ADP
admet-797	97	23	the	the	DET
admet-797	97	24	ionization	ionization	NOUN
admet-797	97	25	state	state	NOUN
admet-797	97	26	of	of	ADP
admet-797	97	27	tetracyclines	tetracycline	NOUN
admet-797	97	28	and	and	CCONJ
admet-797	97	29	metal	metal	NOUN
admet-797	97	30	ion	ion	NOUN
admet-797	97	31	species	specie	NOUN
admet-797	97	32	[	[	X
admet-797	97	33	17,40–44	17,40–44	NUM
admet-797	97	34	]	]	X
admet-797	97	35	.	.	PUNCT
admet-797	98	1	in	in	ADP
admet-797	98	2	this	this	DET
admet-797	98	3	analysis	analysis	NOUN
admet-797	98	4	,	,	PUNCT
admet-797	98	5	macro	macro	X
admet-797	98	6	pka	pka	X
admet-797	98	7	and	and	CCONJ
admet-797	98	8	major	major	ADJ
admet-797	98	9	molecular	molecular	ADJ
admet-797	98	10	species	specie	NOUN
admet-797	98	11	are	be	AUX
admet-797	98	12	considered	consider	VERB
admet-797	98	13	[	[	PUNCT
admet-797	98	14	45,46	45,46	NOUN
admet-797	98	15	]	]	PUNCT
admet-797	98	16	.	.	PUNCT
admet-797	99	1	the	the	DET
admet-797	99	2	fraction	fraction	NOUN
admet-797	99	3	of	of	ADP
admet-797	99	4	each	each	DET
admet-797	99	5	molecular	molecular	ADJ
admet-797	99	6	species	specie	NOUN
admet-797	99	7	(	(	PUNCT
admet-797	99	8	l0	l0	PROPN
admet-797	99	9	,	,	PUNCT
admet-797	99	10	l-1	l-1	PROPN
admet-797	99	11	,	,	PUNCT
admet-797	99	12	l-2	l-2	PROPN
admet-797	99	13	,	,	PUNCT
admet-797	99	14	m2+l-1	m2+l-1	ADP
admet-797	99	15	,	,	PUNCT
admet-797	99	16	m2+l-2	m2+l-2	ADJ
admet-797	99	17	:	:	PUNCT
admet-797	99	18	l	l	NOUN
admet-797	99	19	=	=	SYM
admet-797	99	20	tetracyclines	tetracyclines	PROPN
admet-797	99	21	,	,	PUNCT
admet-797	99	22	m	m	NOUN
admet-797	99	23	=	=	NOUN
admet-797	99	24	metal	metal	NOUN
admet-797	99	25	)	)	PUNCT
admet-797	99	26	(	(	PUNCT
admet-797	99	27	figure	figure	NOUN
admet-797	99	28	3	3	NUM
admet-797	99	29	)	)	PUNCT
admet-797	99	30	was	be	AUX
admet-797	99	31	calculated	calculate	VERB
admet-797	99	32	from	from	ADP
admet-797	99	33	the	the	DET
admet-797	99	34	pka	pka	PROPN
admet-797	99	35	values	value	NOUN
admet-797	99	36	and	and	CCONJ
admet-797	99	37	the	the	DET
admet-797	99	38	metal	metal	NOUN
admet-797	99	39	ion	ion	NOUN
admet-797	99	40	admet	admet	NOUN
admet-797	99	41	&	&	CCONJ
admet-797	99	42	dmpk	dmpk	PROPN
admet-797	99	43	8(2	8(2	NUM
admet-797	99	44	)	)	PUNCT
admet-797	99	45	(	(	PUNCT
admet-797	99	46	2020	2020	NUM
admet-797	99	47	)	)	PUNCT
admet-797	99	48	129	129	NUM
admet-797	99	49	-	-	SYM
admet-797	99	50	138	138	NUM
admet-797	99	51	effect	effect	NOUN
admet-797	99	52	of	of	ADP
admet-797	99	53	metal	metal	NOUN
admet-797	99	54	ions	ion	NOUN
admet-797	99	55	on	on	ADP
admet-797	99	56	pampa	pampa	PROPN
admet-797	99	57	permeation	permeation	NOUN
admet-797	99	58	of	of	ADP
admet-797	99	59	tetracyclines	tetracyclines	PROPN
admet-797	99	60	doi	doi	PROPN
admet-797	99	61	:	:	PUNCT
admet-797	99	62	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	99	63	133	133	NUM
admet-797	99	64	association	association	NOUN
admet-797	99	65	constants	constant	NOUN
admet-797	99	66	(	(	PUNCT
admet-797	99	67	kml	kml	PROPN
admet-797	99	68	=	=	PUNCT
admet-797	100	1	[	[	X
admet-797	100	2	l	l	X
admet-797	100	3	z	z	NOUN
admet-797	100	4	m	m	VERB
admet-797	100	5	2	2	NUM
admet-797	100	6	+	+	CCONJ
admet-797	100	7	]	]	PUNCT
admet-797	100	8	/([m	/([m	PROPN
admet-797	100	9	2	2	NUM
admet-797	100	10	+	+	NUM
admet-797	100	11	]	]	PUNCT
admet-797	100	12	[	[	X
admet-797	100	13	l	l	X
admet-797	100	14	z	z	X
admet-797	100	15	]	]	X
admet-797	100	16	,	,	PUNCT
admet-797	100	17	z	z	NOUN
admet-797	100	18	=	=	SYM
admet-797	100	19	-1	-1	PROPN
admet-797	100	20	,	,	PUNCT
admet-797	100	21	-2	-2	INTJ
admet-797	100	22	)	)	PUNCT
admet-797	100	23	of	of	ADP
admet-797	100	24	tetracyclines	tetracycline	NOUN
admet-797	100	25	(	(	PUNCT
admet-797	100	26	tables	table	NOUN
admet-797	100	27	1	1	NUM
admet-797	100	28	and	and	CCONJ
admet-797	100	29	2	2	NUM
admet-797	100	30	)	)	PUNCT
admet-797	100	31	[	[	X
admet-797	100	32	17,39,47	17,39,47	NUM
admet-797	100	33	]	]	X
admet-797	100	34	.	.	PUNCT
admet-797	101	1	in	in	ADP
admet-797	101	2	the	the	DET
admet-797	101	3	neutral	neutral	ADJ
admet-797	101	4	ph	ph	ADJ
admet-797	101	5	region	region	NOUN
admet-797	101	6	,	,	PUNCT
admet-797	101	7	tetracyclines	tetracycline	NOUN
admet-797	101	8	mainly	mainly	ADV
admet-797	101	9	exist	exist	VERB
admet-797	101	10	as	as	ADP
admet-797	101	11	an	an	DET
admet-797	101	12	equilibrium	equilibrium	NOUN
admet-797	101	13	between	between	ADP
admet-797	101	14	a	a	DET
admet-797	101	15	charge	charge	NOUN
admet-797	101	16	–	–	PUNCT
admet-797	101	17	neutral	neutral	ADJ
admet-797	101	18	form	form	NOUN
admet-797	101	19	(	(	PUNCT
admet-797	101	20	l	l	NOUN
admet-797	101	21	0	0	NUM
admet-797	101	22	)	)	PUNCT
admet-797	101	23	,	,	PUNCT
admet-797	101	24	and	and	CCONJ
admet-797	101	25	negatively	negatively	ADV
admet-797	101	26	charged	charge	VERB
admet-797	101	27	forms	form	NOUN
admet-797	101	28	(	(	PUNCT
admet-797	101	29	l	l	NOUN
admet-797	101	30	-1	-1	NOUN
admet-797	101	31	,	,	PUNCT
admet-797	101	32	l	l	NOUN
admet-797	101	33	-2	-2	NUM
admet-797	101	34	)	)	PUNCT
admet-797	101	35	(	(	PUNCT
admet-797	101	36	figure	figure	VERB
admet-797	101	37	3	3	NUM
admet-797	101	38	)	)	PUNCT
admet-797	102	1	[	[	X
admet-797	102	2	31,40,47	31,40,47	NUM
admet-797	102	3	]	]	PUNCT
admet-797	102	4	.	.	PUNCT
admet-797	103	1	even	even	ADV
admet-797	103	2	though	though	SCONJ
admet-797	103	3	l	l	NOUN
admet-797	103	4	0	0	PUNCT
admet-797	103	5	does	do	AUX
admet-797	103	6	not	not	PART
admet-797	103	7	bind	bind	VERB
admet-797	103	8	to	to	ADP
admet-797	103	9	the	the	DET
admet-797	103	10	metal	metal	NOUN
admet-797	103	11	ions	ion	NOUN
admet-797	103	12	[	[	X
admet-797	103	13	47	47	NUM
admet-797	103	14	]	]	PUNCT
admet-797	103	15	,	,	PUNCT
admet-797	103	16	ca	ca	NOUN
admet-797	103	17	2	2	NUM
admet-797	103	18	+	+	NUM
admet-797	103	19	and	and	CCONJ
admet-797	103	20	mg	mg	PROPN
admet-797	103	21	2	2	NUM
admet-797	103	22	+	+	CCONJ
admet-797	103	23	reduce	reduce	VERB
admet-797	103	24	the	the	DET
admet-797	103	25	fraction	fraction	NOUN
admet-797	103	26	of	of	ADP
admet-797	103	27	l	l	NOUN
admet-797	103	28	0	0	PUNCT
admet-797	103	29	(	(	PUNCT
admet-797	103	30	fl0	fl0	NOUN
admet-797	103	31	)	)	PUNCT
admet-797	103	32	at	at	ADP
admet-797	103	33	ph	ph	PROPN
admet-797	103	34	6.5	6.5	NUM
admet-797	103	35	by	by	ADP
admet-797	103	36	shifting	shift	VERB
admet-797	103	37	the	the	DET
admet-797	103	38	equilibrium	equilibrium	NOUN
admet-797	103	39	(	(	PUNCT
admet-797	103	40	table	table	NOUN
admet-797	103	41	3	3	NUM
admet-797	103	42	)	)	PUNCT
admet-797	103	43	.	.	PUNCT
admet-797	104	1	the	the	DET
admet-797	104	2	reduction	reduction	NOUN
admet-797	104	3	of	of	ADP
admet-797	104	4	fl0	fl0	NOUN
admet-797	104	5	corresponded	correspond	VERB
admet-797	104	6	to	to	ADP
admet-797	104	7	that	that	PRON
admet-797	104	8	of	of	ADP
admet-797	104	9	pe	pe	PROPN
admet-797	104	10	,	,	PUNCT
admet-797	104	11	except	except	SCONJ
admet-797	104	12	for	for	ADP
admet-797	104	13	the	the	DET
admet-797	104	14	ca	ca	NOUN
admet-797	104	15	2	2	NUM
admet-797	104	16	+	+	NUM
admet-797	104	17	effect	effect	NOUN
admet-797	104	18	on	on	ADP
admet-797	104	19	oxy	oxy	ADJ
admet-797	104	20	permeability	permeability	NOUN
admet-797	104	21	,	,	PUNCT
admet-797	104	22	suggesting	suggest	VERB
admet-797	104	23	that	that	SCONJ
admet-797	104	24	the	the	DET
admet-797	104	25	slpampa	slpampa	NOUN
admet-797	104	26	membrane	membrane	NOUN
admet-797	104	27	is	be	AUX
admet-797	104	28	impermeable	impermeable	ADJ
admet-797	104	29	to	to	ADP
admet-797	104	30	m2+l-1	m2+l-1	PROPN
admet-797	104	31	.	.	PUNCT
admet-797	105	1	the	the	DET
admet-797	105	2	ph	ph	PROPN
admet-797	105	3	pe	pe	PROPN
admet-797	105	4	relationship	relationship	NOUN
admet-797	105	5	in	in	ADP
admet-797	105	6	our	our	PRON
admet-797	105	7	previous	previous	ADJ
admet-797	105	8	study	study	NOUN
admet-797	105	9	[	[	X
admet-797	105	10	30	30	NUM
admet-797	105	11	]	]	PUNCT
admet-797	105	12	suggested	suggest	VERB
admet-797	105	13	that	that	SCONJ
admet-797	105	14	tc0	tc0	NOUN
admet-797	105	15	,	,	PUNCT
admet-797	105	16	but	but	CCONJ
admet-797	105	17	not	not	PART
admet-797	105	18	tc-1	tc-1	NOUN
admet-797	105	19	,	,	PUNCT
admet-797	105	20	predominantly	predominantly	ADV
admet-797	105	21	permeates	permeate	VERB
admet-797	105	22	the	the	DET
admet-797	105	23	sl	sl	NOUN
admet-797	105	24	-	-	PUNCT
admet-797	105	25	pampa	pampa	NOUN
admet-797	105	26	membrane	membrane	NOUN
admet-797	105	27	.	.	PUNCT
admet-797	106	1	however	however	ADV
admet-797	106	2	,	,	PUNCT
admet-797	106	3	further	further	ADJ
admet-797	106	4	investigation	investigation	NOUN
admet-797	106	5	is	be	AUX
admet-797	106	6	needed	need	VERB
admet-797	106	7	to	to	PART
admet-797	106	8	better	well	ADV
admet-797	106	9	understand	understand	VERB
admet-797	106	10	the	the	DET
admet-797	106	11	effect	effect	NOUN
admet-797	106	12	of	of	ADP
admet-797	106	13	metal	metal	NOUN
admet-797	106	14	ions	ion	NOUN
admet-797	106	15	on	on	ADP
admet-797	106	16	tetracycline	tetracycline	ADJ
admet-797	106	17	membrane	membrane	NOUN
admet-797	106	18	permeation	permeation	NOUN
admet-797	106	19	.	.	PUNCT
admet-797	107	1	the	the	DET
admet-797	107	2	kml	kml	PROPN
admet-797	107	3	values	value	NOUN
admet-797	107	4	reported	report	VERB
admet-797	107	5	in	in	ADP
admet-797	107	6	the	the	DET
admet-797	107	7	literature	literature	NOUN
admet-797	107	8	show	show	VERB
admet-797	107	9	large	large	ADJ
admet-797	107	10	variation	variation	NOUN
admet-797	107	11	[	[	X
admet-797	107	12	17,39,47	17,39,47	NUM
admet-797	107	13	]	]	X
admet-797	107	14	.	.	PUNCT
admet-797	108	1	the	the	DET
admet-797	108	2	fl0	fl0	NOUN
admet-797	108	3	value	value	NOUN
admet-797	108	4	is	be	AUX
admet-797	108	5	especially	especially	ADV
admet-797	108	6	sensitive	sensitive	ADJ
admet-797	108	7	to	to	ADP
admet-797	108	8	the	the	DET
admet-797	108	9	kml	kml	PROPN
admet-797	108	10	value	value	NOUN
admet-797	108	11	of	of	ADP
admet-797	108	12	m	m	PROPN
admet-797	108	13	2	2	NUM
admet-797	108	14	+	+	NUM
admet-797	108	15	l	l	NOUN
admet-797	108	16	-1	-1	X
admet-797	108	17	.	.	PUNCT
admet-797	109	1	in	in	ADP
admet-797	109	2	addition	addition	NOUN
admet-797	109	3	,	,	PUNCT
admet-797	109	4	m	m	PROPN
admet-797	109	5	2	2	NUM
admet-797	109	6	+	+	NUM
admet-797	109	7	l	l	NOUN
admet-797	109	8	-1	-1	NOUN
admet-797	109	9	chelates	chelate	NOUN
admet-797	109	10	may	may	AUX
admet-797	109	11	have	have	VERB
admet-797	109	12	different	different	ADJ
admet-797	109	13	stoichiometry	stoichiometry	NOUN
admet-797	109	14	(	(	PUNCT
admet-797	109	15	1	1	NUM
admet-797	109	16	:	:	SYM
admet-797	109	17	1	1	NUM
admet-797	109	18	or	or	CCONJ
admet-797	109	19	1	1	NUM
admet-797	109	20	:	:	SYM
admet-797	109	21	2	2	NUM
admet-797	109	22	)	)	PUNCT
admet-797	110	1	[	[	X
admet-797	110	2	17,39,47	17,39,47	NUM
admet-797	110	3	]	]	PUNCT
admet-797	110	4	.	.	PUNCT
admet-797	111	1	micro	micro	ADJ
admet-797	111	2	speciation	speciation	NOUN
admet-797	111	3	with	with	ADP
admet-797	111	4	micro	micro	ADJ
admet-797	111	5	pka	pka	PROPN
admet-797	111	6	values	value	NOUN
admet-797	111	7	is	be	AUX
admet-797	111	8	required	require	VERB
admet-797	111	9	to	to	PART
admet-797	111	10	decouple	decouple	VERB
admet-797	111	11	the	the	DET
admet-797	111	12	contributions	contribution	NOUN
admet-797	111	13	of	of	ADP
admet-797	111	14	uncharged	uncharged	ADJ
admet-797	111	15	and	and	CCONJ
admet-797	111	16	zwitterionic	zwitterionic	ADJ
admet-797	111	17	forms	form	NOUN
admet-797	111	18	in	in	ADP
admet-797	111	19	l	l	NOUN
admet-797	111	20	0	0	PUNCT
admet-797	112	1	[	[	X
admet-797	112	2	45	45	NUM
admet-797	112	3	]	]	PUNCT
admet-797	112	4	.	.	PUNCT
admet-797	113	1	oh	oh	INTJ
admet-797	113	2	n	n	INTJ
admet-797	114	1	+	+	CCONJ
admet-797	115	1	oh	oh	INTJ
admet-797	115	2	o	o	INTJ
admet-797	115	3	o	o	X
admet-797	115	4	ch3	ch3	PROPN
admet-797	115	5	ch3	ch3	PROPN
admet-797	115	6	ch3	ch3	PROPN
admet-797	115	7	o	o	PROPN
admet-797	116	1	nh2	nh2	PROPN
admet-797	116	2	ooh	ooh	INTJ
admet-797	116	3	hh	hh	INTJ
admet-797	117	1	oh	oh	INTJ
admet-797	117	2	h	h	NOUN
admet-797	117	3	h	h	NOUN
admet-797	118	1	h	h	NOUN
admet-797	118	2	–	–	PUNCT
admet-797	119	1	oh	oh	INTJ
admet-797	119	2	n	n	NOUN
admet-797	120	1	+	+	NOUN
admet-797	120	2	o	o	NOUN
admet-797	120	3	o	o	X
admet-797	120	4	o	o	X
admet-797	120	5	ch3	ch3	PROPN
admet-797	120	6	ch3	ch3	PROPN
admet-797	120	7	ch3	ch3	PROPN
admet-797	121	1	o	o	PROPN
admet-797	121	2	nh2	nh2	PROPN
admet-797	121	3	ooh	ooh	INTJ
admet-797	121	4	hh	hh	INTJ
admet-797	122	1	oh	oh	INTJ
admet-797	122	2	h	h	NOUN
admet-797	122	3	h	h	NOUN
admet-797	122	4	h	h	NOUN
admet-797	122	5	–	–	PUNCT
admet-797	122	6	–	–	PUNCT
admet-797	122	7	tc0	tc0	INTJ
admet-797	122	8	tc-1	tc-1	NOUN
admet-797	123	1	pka	pka	NOUN
admet-797	123	2	=	=	PUNCT
admet-797	123	3	7.8	7.8	NUM
admet-797	123	4	oh	oh	INTJ
admet-797	123	5	n	n	ADV
admet-797	123	6	o	o	NOUN
admet-797	123	7	o	o	X
admet-797	123	8	o	o	X
admet-797	123	9	ch3	ch3	PROPN
admet-797	123	10	ch3	ch3	PROPN
admet-797	123	11	ch3	ch3	PROPN
admet-797	123	12	o	o	PROPN
admet-797	124	1	nh2	nh2	PROPN
admet-797	124	2	ooh	ooh	INTJ
admet-797	124	3	hh	hh	INTJ
admet-797	125	1	oh	oh	INTJ
admet-797	125	2	h	h	NOUN
admet-797	125	3	h	h	NOUN
admet-797	125	4	–	–	PUNCT
admet-797	125	5	–	–	PUNCT
admet-797	125	6	pka	pka	X
admet-797	125	7	=	=	SYM
admet-797	125	8	9.6	9.6	NUM
admet-797	125	9	tc-2	tc-2	NOUN
admet-797	125	10	figure	figure	VERB
admet-797	125	11	3	3	NUM
admet-797	125	12	ionization	ionization	NOUN
admet-797	125	13	states	state	NOUN
admet-797	125	14	of	of	ADP
admet-797	125	15	tetracycline	tetracycline	PROPN
admet-797	125	16	(	(	PUNCT
admet-797	125	17	tc	tc	NOUN
admet-797	125	18	)	)	PUNCT
admet-797	125	19	at	at	ADP
admet-797	125	20	the	the	DET
admet-797	125	21	neutral	neutral	ADJ
admet-797	125	22	ph	ph	ADJ
admet-797	125	23	region	region	NOUN
admet-797	125	24	.	.	PUNCT
admet-797	126	1	the	the	DET
admet-797	126	2	macro	macro	NOUN
admet-797	126	3	pka	pka	PROPN
admet-797	126	4	value	value	NOUN
admet-797	126	5	and	and	CCONJ
admet-797	126	6	major	major	ADJ
admet-797	126	7	molecular	molecular	ADJ
admet-797	126	8	species	specie	NOUN
admet-797	126	9	are	be	AUX
admet-797	126	10	shown	show	VERB
admet-797	126	11	in	in	ADP
admet-797	126	12	this	this	DET
admet-797	126	13	figure	figure	NOUN
admet-797	126	14	.	.	PUNCT
admet-797	127	1	table	table	NOUN
admet-797	127	2	2	2	NUM
admet-797	127	3	.	.	PUNCT
admet-797	127	4	association	association	NOUN
admet-797	127	5	constants	constant	NOUN
admet-797	127	6	of	of	ADP
admet-797	127	7	ca	ca	NOUN
admet-797	127	8	2	2	NUM
admet-797	127	9	+	+	NUM
admet-797	127	10	and	and	CCONJ
admet-797	127	11	mg	mg	PROPN
admet-797	127	12	2	2	NUM
admet-797	127	13	+	+	NOUN
admet-797	127	14	with	with	ADP
admet-797	127	15	tetracyclines	tetracycline	NOUN
admet-797	127	16	(	(	PUNCT
admet-797	127	17	l	l	NOUN
admet-797	127	18	=	=	SYM
admet-797	127	19	tc	tc	PROPN
admet-797	127	20	,	,	PUNCT
admet-797	127	21	ctc	ctc	NOUN
admet-797	127	22	,	,	PUNCT
admet-797	127	23	or	or	CCONJ
admet-797	127	24	oxy	oxy	ADJ
admet-797	127	25	)	)	PUNCT
admet-797	127	26	reactions	reaction	NOUN
admet-797	127	27	log	log	VERB
admet-797	127	28	kml	kml	PROPN
admet-797	127	29	tc	tc	PROPN
admet-797	128	1	ctc	ctc	PROPN
admet-797	128	2	oxy	oxy	PROPN
admet-797	128	3	ca2	ca2	PROPN
admet-797	128	4	+	+	PROPN
admet-797	128	5	+	+	NUM
admet-797	128	6	l-1	l-1	X
admet-797	128	7	⇄	⇄	PROPN
admet-797	128	8	ca2+l-1	ca2+l-1	ADP
admet-797	128	9	3.4	3.4	NUM
admet-797	128	10	a	a	PRON
admet-797	128	11	,	,	PUNCT
admet-797	128	12	3.0	3.0	NUM
admet-797	128	13	b	b	NOUN
admet-797	128	14	3.8	3.8	NUM
admet-797	128	15	c	c	NOUN
admet-797	128	16	,	,	PUNCT
admet-797	128	17	2.9	2.9	NUM
admet-797	128	18	b	b	NOUN
admet-797	128	19	,	,	PUNCT
admet-797	128	20	2.9	2.9	NUM
admet-797	128	21	b	b	X
admet-797	128	22	ca2	ca2	PROPN
admet-797	128	23	+	+	PROPN
admet-797	128	24	+	+	CCONJ
admet-797	128	25	l-2	l-2	PROPN
admet-797	128	26	⇄	⇄	PROPN
admet-797	128	27	ca2+l-2	ca2+l-2	PROPN
admet-797	128	28	5.8	5.8	NUM
admet-797	128	29	a	a	NOUN
admet-797	128	30	,	,	PUNCT
admet-797	128	31	4.0	4.0	NUM
admet-797	128	32	b	b	NOUN
admet-797	128	33	5.9	5.9	NUM
admet-797	128	34	c	c	NOUN
admet-797	128	35	,	,	PUNCT
admet-797	128	36	3.9	3.9	NUM
admet-797	128	37	b	b	NOUN
admet-797	128	38	,	,	PUNCT
admet-797	128	39	3.8	3.8	NUM
admet-797	128	40	b	b	NOUN
admet-797	128	41	,	,	PUNCT
admet-797	128	42	4.9	4.9	NUM
admet-797	128	43	c	c	NOUN
admet-797	128	44	mg	mg	PROPN
admet-797	128	45	2	2	NUM
admet-797	128	46	+	+	CCONJ
admet-797	128	47	+	+	NUM
admet-797	128	48	l	l	NOUN
admet-797	128	49	-1	-1	X
admet-797	128	50	⇄	⇄	ADJ
admet-797	128	51	mg	mg	PROPN
admet-797	128	52	2	2	NUM
admet-797	128	53	+	+	NUM
admet-797	128	54	l	l	NOUN
admet-797	128	55	-1	-1	ADP
admet-797	128	56	3.9	3.9	NUM
admet-797	128	57	a	a	PRON
admet-797	128	58	,	,	PUNCT
admet-797	128	59	3.5	3.5	NUM
admet-797	128	60	b	b	NOUN
admet-797	128	61	3.3	3.3	NUM
admet-797	128	62	c	c	NOUN
admet-797	128	63	,	,	PUNCT
admet-797	128	64	3.2	3.2	NUM
admet-797	128	65	b	b	NOUN
admet-797	128	66	3.3	3.3	NUM
admet-797	128	67	b	b	X
admet-797	128	68	mg2	mg2	PROPN
admet-797	128	69	+	+	PROPN
admet-797	128	70	+	+	CCONJ
admet-797	128	71	l-2	l-2	PROPN
admet-797	128	72	⇄	⇄	PROPN
admet-797	128	73	mg2+l-2	mg2+l-2	VERB
admet-797	128	74	4.1	4.1	NUM
admet-797	128	75	a	a	NOUN
admet-797	128	76	,	,	PUNCT
admet-797	128	77	4.2	4.2	NUM
admet-797	128	78	b	b	SYM
admet-797	128	79	4.7	4.7	NUM
admet-797	128	80	c	c	NOUN
admet-797	128	81	,	,	PUNCT
admet-797	128	82	4.1	4.1	NUM
admet-797	128	83	b	b	SYM
admet-797	128	84	4.3	4.3	NUM
admet-797	128	85	b	b	NOUN
admet-797	128	86	,	,	PUNCT
admet-797	128	87	5.2	5.2	NUM
admet-797	128	88	c	c	NOUN
admet-797	128	89	a	a	DET
admet-797	128	90	ref	ref	NOUN
admet-797	128	91	.	.	PUNCT
admet-797	129	1	[	[	X
admet-797	129	2	39	39	NUM
admet-797	129	3	]	]	SYM
admet-797	129	4	b	b	DET
admet-797	129	5	ref	ref	NOUN
admet-797	129	6	.	.	PUNCT
admet-797	130	1	[	[	X
admet-797	130	2	47	47	NUM
admet-797	130	3	]	]	X
admet-797	130	4	c	c	NOUN
admet-797	130	5	ref	ref	NOUN
admet-797	130	6	.	.	PUNCT
admet-797	131	1	[	[	X
admet-797	131	2	17	17	NUM
admet-797	131	3	]	]	PUNCT
admet-797	131	4	in	in	ADP
admet-797	131	5	oct	oct	PROPN
admet-797	131	6	–	–	PUNCT
admet-797	131	7	pampa	pampa	PROPN
admet-797	131	8	,	,	PUNCT
admet-797	131	9	ca2	ca2	PROPN
admet-797	131	10	+	+	PROPN
admet-797	131	11	increased	increase	VERB
admet-797	131	12	the	the	DET
admet-797	131	13	pe	pe	PROPN
admet-797	131	14	values	value	NOUN
admet-797	131	15	of	of	ADP
admet-797	131	16	tc	tc	NOUN
admet-797	131	17	,	,	PUNCT
admet-797	131	18	ctc	ctc	NOUN
admet-797	131	19	,	,	PUNCT
admet-797	131	20	and	and	CCONJ
admet-797	131	21	dmctc	dmctc	ADV
admet-797	131	22	(	(	PUNCT
admet-797	131	23	figure	figure	VERB
admet-797	131	24	4	4	NUM
admet-797	131	25	)	)	PUNCT
admet-797	131	26	.	.	PUNCT
admet-797	132	1	this	this	DET
admet-797	132	2	result	result	NOUN
admet-797	132	3	is	be	AUX
admet-797	132	4	in	in	ADP
admet-797	132	5	good	good	ADJ
admet-797	132	6	agreement	agreement	NOUN
admet-797	132	7	with	with	ADP
admet-797	132	8	the	the	DET
admet-797	132	9	previous	previous	ADJ
admet-797	132	10	studies	study	NOUN
admet-797	132	11	investigating	investigate	VERB
admet-797	132	12	the	the	DET
admet-797	132	13	ca2	ca2	PROPN
admet-797	132	14	+	+	PROPN
admet-797	132	15	effect	effect	NOUN
admet-797	132	16	on	on	ADP
admet-797	132	17	the	the	DET
admet-797	132	18	alcohol	alcohol	NOUN
admet-797	132	19	–	–	PUNCT
admet-797	132	20	water	water	NOUN
admet-797	132	21	partition	partition	NOUN
admet-797	132	22	coefficient	coefficient	NOUN
admet-797	132	23	of	of	ADP
admet-797	132	24	tc	tc	NOUN
admet-797	132	25	(	(	PUNCT
admet-797	132	26	octanol	octanol	NOUN
admet-797	132	27	and	and	CCONJ
admet-797	132	28	isopentanol	isopentanol	NOUN
admet-797	132	29	)	)	PUNCT
admet-797	133	1	[	[	X
admet-797	133	2	21–23	21–23	NUM
admet-797	133	3	]	]	X
admet-797	133	4	.	.	PUNCT
admet-797	134	1	interestingly	interestingly	ADV
admet-797	134	2	,	,	PUNCT
admet-797	134	3	ca2	ca2	PROPN
admet-797	134	4	+	+	PROPN
admet-797	134	5	affected	affect	VERB
admet-797	134	6	sl	sl	INTJ
admet-797	134	7	–	–	PUNCT
admet-797	134	8	pampa	pampa	PROPN
admet-797	134	9	and	and	CCONJ
admet-797	134	10	oct	oct	PROPN
admet-797	134	11	–	–	PUNCT
admet-797	134	12	pampa	pampa	NOUN
admet-797	134	13	in	in	ADP
admet-797	134	14	the	the	DET
admet-797	134	15	opposite	opposite	ADJ
admet-797	134	16	direction	direction	NOUN
admet-797	134	17	for	for	ADP
admet-797	134	18	tc	tc	NOUN
admet-797	134	19	,	,	PUNCT
admet-797	134	20	ctc	ctc	NOUN
admet-797	134	21	,	,	PUNCT
admet-797	134	22	and	and	CCONJ
admet-797	134	23	dmctc	dmctc	NOUN
admet-797	134	24	,	,	PUNCT
admet-797	134	25	but	but	CCONJ
admet-797	134	26	in	in	ADP
admet-797	134	27	the	the	DET
admet-797	134	28	same	same	ADJ
admet-797	134	29	direction	direction	NOUN
admet-797	134	30	for	for	ADP
admet-797	134	31	doxy	doxy	PROPN
admet-797	134	32	,	,	PUNCT
admet-797	134	33	otc	otc	PROPN
admet-797	134	34	,	,	PUNCT
admet-797	134	35	and	and	CCONJ
admet-797	134	36	mino	mino	PROPN
admet-797	134	37	.	.	PUNCT
admet-797	135	1	on	on	ADP
admet-797	135	2	the	the	DET
admet-797	135	3	other	other	ADJ
admet-797	135	4	hand	hand	NOUN
admet-797	135	5	,	,	PUNCT
admet-797	135	6	mg2	mg2	PROPN
admet-797	135	7	+	+	PROPN
admet-797	135	8	decreased	decrease	VERB
admet-797	135	9	the	the	DET
admet-797	135	10	pe	pe	PROPN
admet-797	135	11	values	value	NOUN
admet-797	135	12	of	of	ADP
admet-797	135	13	all	all	DET
admet-797	135	14	tetracyclines	tetracycline	NOUN
admet-797	135	15	in	in	ADP
admet-797	135	16	oct	oct	PROPN
admet-797	135	17	–	–	PUNCT
admet-797	135	18	pampa	pampa	NOUN
admet-797	135	19	except	except	SCONJ
admet-797	135	20	for	for	ADP
admet-797	135	21	ctc	ctc	PROPN
admet-797	135	22	(	(	PUNCT
admet-797	135	23	no	no	DET
admet-797	135	24	effect	effect	NOUN
admet-797	135	25	)	)	PUNCT
admet-797	135	26	.	.	PUNCT
admet-797	136	1	these	these	DET
admet-797	136	2	results	result	NOUN
admet-797	136	3	suggest	suggest	VERB
admet-797	136	4	that	that	SCONJ
admet-797	136	5	it	it	PRON
admet-797	136	6	could	could	AUX
admet-797	136	7	be	be	AUX
admet-797	136	8	inappropriate	inappropriate	ADJ
admet-797	136	9	to	to	PART
admet-797	136	10	use	use	VERB
admet-797	136	11	octanol	octanol	NOUN
admet-797	136	12	as	as	ADP
admet-797	136	13	a	a	DET
admet-797	136	14	surrogate	surrogate	NOUN
admet-797	136	15	of	of	ADP
admet-797	136	16	a	a	DET
admet-797	136	17	phospholipid	phospholipid	NOUN
admet-797	136	18	membrane	membrane	NOUN
admet-797	136	19	for	for	ADP
admet-797	136	20	investigating	investigate	VERB
admet-797	136	21	the	the	DET
admet-797	136	22	effect	effect	NOUN
admet-797	136	23	of	of	ADP
admet-797	136	24	divalent	divalent	ADJ
admet-797	136	25	metal	metal	NOUN
admet-797	136	26	ions	ion	NOUN
admet-797	136	27	.	.	PUNCT
admet-797	137	1	in	in	ADP
admet-797	137	2	oct	oct	PROPN
admet-797	137	3	-	-	PUNCT
admet-797	137	4	pampa	pampa	PROPN
admet-797	137	5	,	,	PUNCT
admet-797	137	6	the	the	DET
admet-797	137	7	octanol	octanol	NOUN
admet-797	137	8	phase	phase	NOUN
admet-797	137	9	could	could	AUX
admet-797	137	10	contain	contain	VERB
admet-797	137	11	water	water	NOUN
admet-797	137	12	molecules	molecule	NOUN
admet-797	137	13	in	in	ADP
admet-797	137	14	reverse	reverse	ADJ
admet-797	137	15	micelle	micelle	NOUN
admet-797	137	16	structures	structure	NOUN
admet-797	137	17	[	[	X
admet-797	137	18	48	48	NUM
admet-797	137	19	]	]	PUNCT
admet-797	137	20	.	.	PUNCT
admet-797	138	1	this	this	PRON
admet-797	138	2	may	may	AUX
admet-797	138	3	facilitate	facilitate	VERB
admet-797	138	4	the	the	DET
admet-797	138	5	permeation	permeation	NOUN
admet-797	138	6	of	of	ADP
admet-797	138	7	charged	charge	VERB
admet-797	138	8	species	specie	NOUN
admet-797	138	9	,	,	PUNCT
admet-797	138	10	such	such	ADJ
admet-797	138	11	as	as	ADP
admet-797	138	12	the	the	DET
admet-797	138	13	tc	tc	NOUN
admet-797	138	14	–	–	PUNCT
admet-797	138	15	metal	metal	NOUN
admet-797	138	16	chelates	chelate	NOUN
admet-797	138	17	.	.	PUNCT
admet-797	139	1	in	in	ADP
admet-797	139	2	similar	similar	ADJ
admet-797	139	3	to	to	ADP
admet-797	139	4	sl	sl	NUM
admet-797	139	5	–	–	PUNCT
admet-797	139	6	pampa	pampa	PROPN
admet-797	139	7	,	,	PUNCT
admet-797	139	8	the	the	DET
admet-797	139	9	addition	addition	NOUN
admet-797	139	10	of	of	ADP
admet-797	139	11	mucin	mucin	NOUN
admet-797	139	12	did	do	AUX
admet-797	139	13	not	not	PART
admet-797	139	14	affect	affect	VERB
admet-797	139	15	the	the	DET
admet-797	139	16	pe	pe	PROPN
admet-797	139	17	values	value	NOUN
admet-797	139	18	in	in	ADP
admet-797	139	19	oct	oct	PROPN
admet-797	139	20	–	–	PUNCT
admet-797	139	21	pampa	pampa	PROPN
admet-797	139	22	,	,	PUNCT
admet-797	139	23	suggesting	suggest	VERB
admet-797	139	24	that	that	SCONJ
admet-797	139	25	there	there	PRON
admet-797	139	26	is	be	VERB
admet-797	139	27	no	no	DET
admet-797	139	28	interaction	interaction	NOUN
admet-797	139	29	between	between	ADP
admet-797	139	30	tetracyclines	tetracycline	NOUN
admet-797	139	31	and	and	CCONJ
admet-797	139	32	mucin	mucin	NOUN
admet-797	139	33	.	.	PUNCT
admet-797	140	1	as	as	SCONJ
admet-797	140	2	expected	expect	VERB
admet-797	140	3	,	,	PUNCT
admet-797	140	4	there	there	PRON
admet-797	140	5	is	be	VERB
admet-797	140	6	a	a	DET
admet-797	140	7	good	good	ADJ
admet-797	140	8	correlation	correlation	NOUN
admet-797	140	9	between	between	ADP
admet-797	140	10	log	log	PROPN
admet-797	140	11	doct	doct	NOUN
admet-797	140	12	and	and	CCONJ
admet-797	140	13	log	log	VERB
admet-797	140	14	pe	pe	INTJ
admet-797	140	15	in	in	ADP
admet-797	140	16	oct	oct	PROPN
admet-797	140	17	–	–	PUNCT
admet-797	140	18	pampa	pampa	PROPN
admet-797	140	19	(	(	PUNCT
admet-797	140	20	figure	figure	NOUN
admet-797	140	21	5	5	NUM
admet-797	140	22	)	)	PUNCT
admet-797	141	1	[	[	X
admet-797	141	2	35,36	35,36	NUM
admet-797	141	3	]	]	PUNCT
admet-797	141	4	.	.	PUNCT
admet-797	142	1	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	142	2	kiyohiko	kiyohiko	PROPN
admet-797	142	3	sugano	sugano	PROPN
admet-797	142	4	et	et	PROPN
admet-797	142	5	al	al	PROPN
admet-797	142	6	.	.	PROPN
admet-797	142	7	admet	admet	PROPN
admet-797	142	8	&	&	CCONJ
admet-797	142	9	dmpk	dmpk	PROPN
admet-797	142	10	8(2	8(2	NUM
admet-797	142	11	)	)	PUNCT
admet-797	142	12	(	(	PUNCT
admet-797	142	13	2020	2020	NUM
admet-797	142	14	)	)	PUNCT
admet-797	142	15	129	129	NUM
admet-797	142	16	-	-	SYM
admet-797	142	17	138	138	NUM
admet-797	142	18	134	134	NUM
admet-797	142	19	table	table	NOUN
admet-797	142	20	3	3	NUM
admet-797	142	21	.	.	PUNCT
admet-797	142	22	fraction	fraction	NOUN
admet-797	142	23	of	of	ADP
admet-797	142	24	molecular	molecular	ADJ
admet-797	142	25	species	specie	NOUN
admet-797	142	26	at	at	ADP
admet-797	142	27	ph	ph	PROPN
admet-797	142	28	6.5	6.5	NUM
admet-797	142	29	a	a	DET
admet-797	142	30	tetracyclines	tetracycline	NOUN
admet-797	142	31	(	(	PUNCT
admet-797	142	32	l	l	NOUN
admet-797	142	33	)	)	PUNCT
admet-797	142	34	metal	metal	NOUN
admet-797	142	35	ions	ion	NOUN
admet-797	142	36	(	(	PUNCT
admet-797	142	37	m	m	NOUN
admet-797	142	38	)	)	PUNCT
admet-797	142	39	fraction	fraction	NOUN
admet-797	142	40	of	of	ADP
admet-797	142	41	molecular	molecular	ADJ
admet-797	142	42	species	specie	NOUN
admet-797	142	43	b	b	NOUN
admet-797	142	44	reduction	reduction	NOUN
admet-797	142	45	%	%	NOUN
admet-797	142	46	l	l	NOUN
admet-797	142	47	0	0	PUNCT
admet-797	142	48	l	l	NOUN
admet-797	142	49	-1	-1	NOUN
admet-797	143	1	l	l	NOUN
admet-797	144	1	-2	-2	INTJ
admet-797	144	2	m	m	VERB
admet-797	144	3	2	2	NUM
admet-797	144	4	+	+	NUM
admet-797	144	5	l	l	NOUN
admet-797	144	6	-1	-1	NOUN
admet-797	144	7	m	m	VERB
admet-797	144	8	2	2	NUM
admet-797	144	9	+	+	NUM
admet-797	144	10	l	l	NOUN
admet-797	144	11	-2	-2	NOUN
admet-797	145	1	fl0	fl0	VERB
admet-797	145	2	pe	pe	INTJ
admet-797	146	1	tc	tc	VERB
admet-797	146	2	none	none	NOUN
admet-797	146	3	0.95	0.95	NUM
admet-797	146	4	0.05	0.05	NUM
admet-797	146	5	<	<	X
admet-797	146	6	0.01	0.01	NUM
admet-797	146	7	c	c	NOUN
admet-797	146	8	ca	ca	NOUN
admet-797	146	9	2	2	NUM
admet-797	146	10	+	+	CCONJ
admet-797	146	11	d	d	NOUN
admet-797	146	12	,	,	PUNCT
admet-797	146	13	e	e	NOUN
admet-797	146	14	0.55	0.55	NUM
admet-797	146	15	0.03	0.03	NUM
admet-797	146	16	<	<	X
admet-797	146	17	0.01	0.01	NUM
admet-797	146	18	0.35	0.35	NUM
admet-797	146	19	0.07	0.07	NUM
admet-797	146	20	42	42	NUM
admet-797	146	21	35	35	NUM
admet-797	146	22	mg2	mg2	NUM
admet-797	146	23	+	+	PROPN
admet-797	146	24	d	d	NOUN
admet-797	146	25	,	,	PUNCT
admet-797	146	26	e	e	NOUN
admet-797	146	27	0.33	0.33	NUM
admet-797	146	28	0.02	0.02	NUM
admet-797	146	29	<	<	X
admet-797	146	30	0.01	0.01	NUM
admet-797	146	31	0.65	0.65	NUM
admet-797	146	32	<	<	NOUN
admet-797	146	33	0.01	0.01	NUM
admet-797	146	34	65	65	NUM
admet-797	146	35	67	67	NUM
admet-797	146	36	ctc	ctc	NOUN
admet-797	146	37	none	none	NOUN
admet-797	146	38	0.93	0.93	NUM
admet-797	146	39	0.07	0.07	NUM
admet-797	146	40	<	<	X
admet-797	146	41	0.01	0.01	NUM
admet-797	146	42	ca	ca	NOUN
admet-797	146	43	2	2	NUM
admet-797	146	44	+	+	NUM
admet-797	146	45	d	d	NOUN
admet-797	146	46	,	,	PUNCT
admet-797	146	47	e	e	NOUN
admet-797	146	48	0.24	0.24	NUM
admet-797	146	49	0.02	0.02	NUM
admet-797	146	50	<	<	NOUN
admet-797	146	51	0.01	0.01	NUM
admet-797	146	52	0.61	0.61	NUM
admet-797	146	53	0.12	0.12	NUM
admet-797	146	54	74	74	NUM
admet-797	146	55	64	64	NUM
admet-797	146	56	mg2	mg2	NUM
admet-797	146	57	+	+	PROPN
admet-797	146	58	d	d	NOUN
admet-797	146	59	,	,	PUNCT
admet-797	146	60	e	e	NOUN
admet-797	146	61	0.53	0.53	NUM
admet-797	146	62	0.04	0.04	NUM
admet-797	146	63	<	<	NOUN
admet-797	146	64	0.01	0.01	NUM
admet-797	146	65	0.42	0.42	NUM
admet-797	146	66	0.02	0.02	NUM
admet-797	146	67	43	43	NUM
admet-797	146	68	56	56	NUM
admet-797	146	69	oxy	oxy	ADJ
admet-797	146	70	none	none	NOUN
admet-797	146	71	0.91	0.91	NUM
admet-797	146	72	0.09	0.09	NUM
admet-797	146	73	<	<	X
admet-797	146	74	0.01	0.01	NUM
admet-797	146	75	ca	ca	NOUN
admet-797	146	76	2	2	NUM
admet-797	146	77	+	+	NUM
admet-797	146	78	d	d	NOUN
admet-797	146	79	,	,	PUNCT
admet-797	146	80	e	e	X
admet-797	146	81	0.66	0.66	NUM
admet-797	146	82	0.07	0.07	NUM
admet-797	146	83	<	<	X
admet-797	146	84	0.01	0.01	NUM
admet-797	146	85	0.26	0.26	NUM
admet-797	146	86	<	<	X
admet-797	146	87	0.01	0.01	NUM
admet-797	146	88	27	27	NUM
admet-797	146	89	61	61	NUM
admet-797	146	90	mg2	mg2	NUM
admet-797	146	91	+	+	PROPN
admet-797	146	92	d	d	NOUN
admet-797	146	93	,	,	PUNCT
admet-797	146	94	e	e	X
admet-797	146	95	0.47	0.47	NUM
admet-797	146	96	0.05	0.05	NUM
admet-797	146	97	<	<	X
admet-797	146	98	0.01	0.01	NUM
admet-797	146	99	0.47	0.47	NUM
admet-797	146	100	0.02	0.02	NUM
admet-797	146	101	49	49	NUM
admet-797	146	102	64	64	NUM
admet-797	146	103	a	a	DET
admet-797	146	104	activity	activity	NOUN
admet-797	146	105	coefficients	coefficient	NOUN
admet-797	146	106	were	be	AUX
admet-797	146	107	assumed	assume	VERB
admet-797	146	108	to	to	PART
admet-797	146	109	be	be	AUX
admet-797	146	110	1	1	NUM
admet-797	146	111	.	.	PUNCT
admet-797	147	1	see	see	VERB
admet-797	147	2	ref	ref	NOUN
admet-797	147	3	.	.	PUNCT
admet-797	148	1	[	[	X
admet-797	148	2	39	39	NUM
admet-797	148	3	]	]	PUNCT
admet-797	148	4	for	for	ADP
admet-797	148	5	details	detail	NOUN
admet-797	148	6	;	;	PUNCT
admet-797	148	7	b	b	X
admet-797	148	8	l	l	NOUN
admet-797	148	9	=	=	SYM
admet-797	148	10	tc	tc	PROPN
admet-797	148	11	,	,	PUNCT
admet-797	148	12	ctc	ctc	NOUN
admet-797	148	13	,	,	PUNCT
admet-797	148	14	or	or	CCONJ
admet-797	148	15	oxy	oxy	NOUN
admet-797	148	16	.	.	PUNCT
admet-797	148	17	m	m	PROPN
admet-797	149	1	=	=	VERB
admet-797	149	2	ca	ca	NOUN
admet-797	149	3	or	or	CCONJ
admet-797	149	4	mg	mg	PROPN
admet-797	149	5	;	;	PUNCT
admet-797	149	6	c	c	NOUN
admet-797	149	7	not	not	PART
admet-797	149	8	applicable	applicable	ADJ
admet-797	149	9	;	;	PUNCT
admet-797	149	10	d	d	PROPN
admet-797	149	11	5.0×10	5.0×10	NUM
admet-797	149	12	-3	-3	PUNCT
admet-797	149	13	mol	mol	PROPN
admet-797	149	14	/	/	SYM
admet-797	149	15	l	l	NOUN
admet-797	149	16	;	;	PUNCT
admet-797	149	17	e	e	X
admet-797	149	18	the	the	DET
admet-797	149	19	kml	kml	PROPN
admet-797	149	20	values	value	NOUN
admet-797	149	21	were	be	AUX
admet-797	149	22	from	from	ADP
admet-797	149	23	ref	ref	NOUN
admet-797	149	24	.	.	PUNCT
admet-797	150	1	[	[	X
admet-797	150	2	39	39	NUM
admet-797	150	3	]	]	PUNCT
admet-797	150	4	,	,	PUNCT
admet-797	150	5	[	[	X
admet-797	150	6	17	17	NUM
admet-797	150	7	]	]	PUNCT
admet-797	150	8	,	,	PUNCT
admet-797	150	9	[	[	X
admet-797	150	10	47	47	NUM
admet-797	150	11	]	]	PUNCT
admet-797	150	12	for	for	ADP
admet-797	150	13	tc	tc	NOUN
admet-797	150	14	,	,	PUNCT
admet-797	150	15	ctc	ctc	NOUN
admet-797	150	16	,	,	PUNCT
admet-797	150	17	and	and	CCONJ
admet-797	150	18	oyx	oyx	PROPN
admet-797	150	19	,	,	PUNCT
admet-797	150	20	respectively	respectively	ADV
admet-797	150	21	.	.	PUNCT
admet-797	151	1	figure	figure	NOUN
admet-797	151	2	4	4	NUM
admet-797	151	3	.	.	PUNCT
admet-797	151	4	effect	effect	NOUN
admet-797	151	5	of	of	ADP
admet-797	151	6	additives	additive	NOUN
admet-797	151	7	on	on	ADP
admet-797	151	8	oct	oct	PROPN
admet-797	151	9	–	–	PUNCT
admet-797	151	10	pampa	pampa	PROPN
admet-797	151	11	permeation	permeation	NOUN
admet-797	151	12	of	of	ADP
admet-797	151	13	tetracyclines	tetracycline	NOUN
admet-797	151	14	(	(	PUNCT
admet-797	151	15	mean	mean	PROPN
admet-797	151	16	±	±	NUM
admet-797	151	17	sd	sd	NOUN
admet-797	151	18	,	,	PUNCT
admet-797	151	19	n	n	NOUN
admet-797	151	20	=	=	SYM
admet-797	151	21	3	3	NUM
admet-797	151	22	6	6	NUM
admet-797	151	23	)	)	PUNCT
admet-797	151	24	.	.	PUNCT
admet-797	152	1	admet	admet	PROPN
admet-797	152	2	&	&	CCONJ
admet-797	152	3	dmpk	dmpk	PROPN
admet-797	152	4	8(2	8(2	NUM
admet-797	152	5	)	)	PUNCT
admet-797	152	6	(	(	PUNCT
admet-797	152	7	2020	2020	NUM
admet-797	152	8	)	)	PUNCT
admet-797	152	9	129	129	NUM
admet-797	152	10	-	-	SYM
admet-797	152	11	138	138	NUM
admet-797	152	12	effect	effect	NOUN
admet-797	152	13	of	of	ADP
admet-797	152	14	metal	metal	NOUN
admet-797	152	15	ions	ion	NOUN
admet-797	152	16	on	on	ADP
admet-797	152	17	pampa	pampa	PROPN
admet-797	152	18	permeation	permeation	NOUN
admet-797	152	19	of	of	ADP
admet-797	152	20	tetracyclines	tetracyclines	PROPN
admet-797	152	21	doi	doi	PROPN
admet-797	152	22	:	:	PUNCT
admet-797	152	23	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	NOUN
admet-797	152	24	135	135	NUM
admet-797	152	25	figure	figure	NOUN
admet-797	152	26	5	5	NUM
admet-797	152	27	.	.	PUNCT
admet-797	152	28	correlation	correlation	NOUN
admet-797	152	29	between	between	ADP
admet-797	152	30	log	log	PROPN
admet-797	152	31	doct	doct	NOUN
admet-797	152	32	and	and	CCONJ
admet-797	152	33	log	log	VERB
admet-797	152	34	pe	pe	PRON
admet-797	152	35	of	of	ADP
admet-797	152	36	tetracyclines	tetracyclines	PROPN
admet-797	152	37	in	in	ADP
admet-797	152	38	oct	oct	PROPN
admet-797	152	39	–	–	PUNCT
admet-797	152	40	pampa	pampa	PROPN
admet-797	152	41	.	.	PUNCT
admet-797	153	1	the	the	DET
admet-797	153	2	log	log	NOUN
admet-797	153	3	doct	doct	NOUN
admet-797	153	4	values	value	NOUN
admet-797	153	5	were	be	AUX
admet-797	153	6	taken	take	VERB
admet-797	153	7	from	from	ADP
admet-797	153	8	the	the	DET
admet-797	153	9	literatrue	literatrue	NOUN
admet-797	153	10	[	[	X
admet-797	153	11	30	30	NUM
admet-797	153	12	]	]	PUNCT
admet-797	153	13	.	.	PUNCT
admet-797	154	1	clinically	clinically	ADV
admet-797	154	2	,	,	PUNCT
admet-797	154	3	co	co	NOUN
admet-797	154	4	-	-	NOUN
admet-797	154	5	administration	administration	NOUN
admet-797	154	6	of	of	ADP
admet-797	154	7	food	food	NOUN
admet-797	154	8	and	and	CCONJ
admet-797	154	9	milk	milk	NOUN
admet-797	154	10	has	have	AUX
admet-797	154	11	been	be	AUX
admet-797	154	12	reported	report	VERB
admet-797	154	13	to	to	PART
admet-797	154	14	decrease	decrease	VERB
admet-797	154	15	the	the	DET
admet-797	154	16	bioavailability	bioavailability	NOUN
admet-797	154	17	of	of	ADP
admet-797	154	18	tetracyclines	tetracycline	NOUN
admet-797	154	19	(	(	PUNCT
admet-797	154	20	table	table	NOUN
admet-797	154	21	4	4	NUM
admet-797	154	22	)	)	PUNCT
admet-797	155	1	[	[	X
admet-797	155	2	4–10	4–10	NOUN
admet-797	155	3	]	]	X
admet-797	155	4	.	.	PUNCT
admet-797	156	1	the	the	DET
admet-797	156	2	effect	effect	NOUN
admet-797	156	3	of	of	ADP
admet-797	156	4	food	food	NOUN
admet-797	156	5	and	and	CCONJ
admet-797	156	6	milk	milk	NOUN
admet-797	156	7	on	on	ADP
admet-797	156	8	bioavailability	bioavailability	NOUN
admet-797	156	9	is	be	AUX
admet-797	156	10	greater	great	ADJ
admet-797	156	11	for	for	ADP
admet-797	156	12	tc	tc	NOUN
admet-797	156	13	and	and	CCONJ
admet-797	156	14	oxy	oxy	ADJ
admet-797	156	15	,	,	PUNCT
admet-797	156	16	but	but	CCONJ
admet-797	156	17	relatively	relatively	ADV
admet-797	156	18	small	small	ADJ
admet-797	156	19	for	for	ADP
admet-797	156	20	doxy	doxy	PROPN
admet-797	156	21	and	and	CCONJ
admet-797	156	22	mino	mino	VERB
admet-797	157	1	[	[	X
admet-797	157	2	4	4	NUM
admet-797	157	3	]	]	PUNCT
admet-797	157	4	.	.	PUNCT
admet-797	158	1	however	however	ADV
admet-797	158	2	,	,	PUNCT
admet-797	158	3	in	in	ADP
admet-797	158	4	the	the	DET
admet-797	158	5	present	present	ADJ
admet-797	158	6	study	study	NOUN
admet-797	158	7	,	,	PUNCT
admet-797	158	8	the	the	DET
admet-797	158	9	percent	percent	NOUN
admet-797	158	10	reduction	reduction	NOUN
admet-797	158	11	of	of	ADP
admet-797	158	12	pe	pe	INTJ
admet-797	158	13	by	by	ADP
admet-797	158	14	ca	ca	PROPN
admet-797	158	15	2	2	NUM
admet-797	158	16	+	+	CCONJ
admet-797	158	17	was	be	AUX
admet-797	158	18	smallest	small	ADJ
admet-797	158	19	for	for	ADP
admet-797	158	20	tc	tc	PROPN
admet-797	158	21	(	(	PUNCT
admet-797	158	22	mino	mino	PROPN
admet-797	158	23	(	(	PUNCT
admet-797	158	24	87	87	NUM
admet-797	158	25	%	%	NOUN
admet-797	158	26	)	)	PUNCT
admet-797	158	27	>	>	X
admet-797	159	1	dmctc	dmctc	ADV
admet-797	159	2	(	(	PUNCT
admet-797	159	3	67	67	NUM
admet-797	159	4	%	%	NOUN
admet-797	159	5	)	)	PUNCT
admet-797	160	1	≈	≈	PROPN
admet-797	160	2	ctc	ctc	PROPN
admet-797	160	3	(	(	PUNCT
admet-797	160	4	64	64	NUM
admet-797	160	5	%	%	NOUN
admet-797	160	6	)	)	PUNCT
admet-797	161	1	≈	≈	PROPN
admet-797	161	2	doxy	doxy	PROPN
admet-797	161	3	(	(	PUNCT
admet-797	161	4	62	62	NUM
admet-797	161	5	%	%	NOUN
admet-797	161	6	)	)	PUNCT
admet-797	162	1	≈	≈	PROPN
admet-797	162	2	oxy	oxy	NOUN
admet-797	162	3	(	(	PUNCT
admet-797	162	4	61	61	NUM
admet-797	162	5	%	%	NOUN
admet-797	162	6	)	)	PUNCT
admet-797	162	7	>	>	X
admet-797	162	8	tc	tc	X
admet-797	162	9	(	(	PUNCT
admet-797	162	10	35	35	NUM
admet-797	162	11	%	%	NOUN
admet-797	162	12	)	)	PUNCT
admet-797	162	13	)	)	PUNCT
admet-797	162	14	.	.	PUNCT
admet-797	163	1	the	the	DET
admet-797	163	2	pe	pe	PROPN
admet-797	163	3	values	value	NOUN
admet-797	163	4	of	of	ADP
admet-797	163	5	mino	mino	PROPN
admet-797	163	6	and	and	CCONJ
admet-797	163	7	doxy	doxy	PROPN
admet-797	163	8	are	be	AUX
admet-797	163	9	higher	high	ADJ
admet-797	163	10	than	than	ADP
admet-797	163	11	that	that	PRON
admet-797	163	12	of	of	ADP
admet-797	163	13	the	the	DET
admet-797	163	14	other	other	ADJ
admet-797	163	15	tetracyclines	tetracyclines	PROPN
admet-797	163	16	.	.	PUNCT
admet-797	164	1	in	in	ADP
admet-797	164	2	addition	addition	NOUN
admet-797	164	3	,	,	PUNCT
admet-797	164	4	after	after	SCONJ
admet-797	164	5	oral	oral	ADJ
admet-797	164	6	administration	administration	NOUN
admet-797	164	7	,	,	PUNCT
admet-797	164	8	mino	mino	PROPN
admet-797	164	9	and	and	CCONJ
admet-797	164	10	doxy	doxy	PROPN
admet-797	164	11	are	be	AUX
admet-797	164	12	almost	almost	ADV
admet-797	164	13	completely	completely	ADV
admet-797	164	14	absorbed	absorb	VERB
admet-797	164	15	,	,	PUNCT
admet-797	164	16	whereas	whereas	SCONJ
admet-797	164	17	tc	tc	NOUN
admet-797	164	18	,	,	PUNCT
admet-797	164	19	oxy	oxy	PROPN
admet-797	164	20	,	,	PUNCT
admet-797	164	21	ctc	ctc	NOUN
admet-797	164	22	and	and	CCONJ
admet-797	164	23	dmctc	dmctc	NOUN
admet-797	164	24	are	be	AUX
admet-797	164	25	incompletely	incompletely	ADV
admet-797	164	26	absorbed	absorb	VERB
admet-797	164	27	[	[	PUNCT
admet-797	164	28	4	4	NUM
admet-797	164	29	]	]	PUNCT
admet-797	164	30	.	.	PUNCT
admet-797	165	1	therefore	therefore	ADV
admet-797	165	2	,	,	PUNCT
admet-797	165	3	the	the	DET
admet-797	165	4	reduction	reduction	NOUN
admet-797	165	5	of	of	ADP
admet-797	165	6	pe	pe	INTJ
admet-797	165	7	by	by	ADP
admet-797	165	8	ca	ca	PROPN
admet-797	165	9	2	2	NUM
admet-797	165	10	+	+	CCONJ
admet-797	165	11	may	may	AUX
admet-797	165	12	have	have	VERB
admet-797	165	13	less	less	ADJ
admet-797	165	14	impact	impact	NOUN
admet-797	165	15	on	on	ADP
admet-797	165	16	the	the	DET
admet-797	165	17	bioavailability	bioavailability	NOUN
admet-797	165	18	of	of	ADP
admet-797	165	19	mino	mino	PROPN
admet-797	165	20	and	and	CCONJ
admet-797	165	21	doxy	doxy	PROPN
admet-797	165	22	.	.	PUNCT
admet-797	166	1	barza	barza	NOUN
admet-797	166	2	et	et	PROPN
admet-797	166	3	al	al	PROPN
admet-797	166	4	.	.	PROPN
admet-797	166	5	reported	report	VERB
admet-797	166	6	that	that	SCONJ
admet-797	166	7	,	,	PUNCT
admet-797	166	8	after	after	ADP
admet-797	166	9	the	the	DET
admet-797	166	10	administration	administration	NOUN
admet-797	166	11	of	of	ADP
admet-797	166	12	tetracyclines	tetracyclines	PROPN
admet-797	166	13	with	with	ADP
admet-797	166	14	milk	milk	NOUN
admet-797	166	15	into	into	ADP
admet-797	166	16	the	the	DET
admet-797	166	17	ileal	ileal	ADJ
admet-797	166	18	loop	loop	NOUN
admet-797	166	19	in	in	ADP
admet-797	166	20	dogs	dog	NOUN
admet-797	166	21	,	,	PUNCT
admet-797	166	22	the	the	DET
admet-797	166	23	remaining	remain	VERB
admet-797	166	24	fraction	fraction	NOUN
admet-797	166	25	in	in	ADP
admet-797	166	26	the	the	DET
admet-797	166	27	luminal	luminal	ADJ
admet-797	166	28	contents	content	NOUN
admet-797	166	29	is	be	AUX
admet-797	166	30	doxy	doxy	PROPN
admet-797	166	31	>	>	X
admet-797	166	32	>	>	X
admet-797	166	33	oxy	oxy	PROPN
admet-797	167	1	≈	≈	PROPN
admet-797	167	2	mino	mino	PROPN
admet-797	168	1	≈	≈	PROPN
admet-797	168	2	tc	tc	PRON
admet-797	169	1	[	[	X
admet-797	169	2	49	49	NUM
admet-797	169	3	]	]	PUNCT
admet-797	169	4	.	.	PUNCT
admet-797	170	1	lipophilicity	lipophilicity	PROPN
admet-797	170	2	may	may	AUX
admet-797	170	3	play	play	VERB
admet-797	170	4	a	a	DET
admet-797	170	5	role	role	NOUN
admet-797	170	6	in	in	ADP
admet-797	170	7	food	food	NOUN
admet-797	170	8	and	and	CCONJ
admet-797	170	9	milk	milk	NOUN
admet-797	170	10	binding	bind	VERB
admet-797	170	11	.	.	PUNCT
admet-797	171	1	the	the	DET
admet-797	171	2	balance	balance	NOUN
admet-797	171	3	of	of	ADP
admet-797	171	4	metal	metal	NOUN
admet-797	171	5	ion	ion	NOUN
admet-797	171	6	chelating	chelating	NOUN
admet-797	171	7	,	,	PUNCT
admet-797	171	8	food/	food/	NUM
admet-797	171	9	milk	milk	NOUN
admet-797	171	10	binding	bind	VERB
admet-797	171	11	,	,	PUNCT
admet-797	171	12	and	and	CCONJ
admet-797	171	13	membrane	membrane	NOUN
admet-797	171	14	permeation	permeation	NOUN
admet-797	171	15	may	may	AUX
admet-797	171	16	determine	determine	VERB
admet-797	171	17	the	the	DET
admet-797	171	18	extent	extent	NOUN
admet-797	171	19	of	of	ADP
admet-797	171	20	food	food	NOUN
admet-797	171	21	and	and	CCONJ
admet-797	171	22	milk	milk	NOUN
admet-797	171	23	effects	effect	NOUN
admet-797	171	24	.	.	PUNCT
admet-797	172	1	interestingly	interestingly	ADV
admet-797	172	2	,	,	PUNCT
admet-797	172	3	the	the	DET
admet-797	172	4	effects	effect	NOUN
admet-797	172	5	of	of	ADP
admet-797	172	6	metal	metal	NOUN
admet-797	172	7	ions	ion	NOUN
admet-797	172	8	and	and	CCONJ
admet-797	172	9	ph	ph	NOUN
admet-797	172	10	[	[	PUNCT
admet-797	172	11	30	30	NUM
admet-797	172	12	]	]	PUNCT
admet-797	172	13	on	on	ADP
admet-797	172	14	the	the	DET
admet-797	172	15	bioavailability	bioavailability	NOUN
admet-797	172	16	of	of	ADP
admet-797	172	17	tc	tc	NUM
admet-797	172	18	to	to	ADP
admet-797	172	19	e.coli	e.coli	NOUN
admet-797	172	20	are	be	AUX
admet-797	172	21	similar	similar	ADJ
admet-797	172	22	to	to	ADP
admet-797	172	23	that	that	PRON
admet-797	172	24	on	on	ADP
admet-797	172	25	sl	sl	NOUN
admet-797	172	26	-	-	PUNCT
admet-797	172	27	pampa	pampa	NOUN
admet-797	172	28	permeation	permeation	NOUN
admet-797	172	29	[	[	X
admet-797	172	30	50	50	NUM
admet-797	172	31	]	]	PUNCT
admet-797	172	32	.	.	PUNCT
admet-797	173	1	table	table	NOUN
admet-797	173	2	4	4	NUM
admet-797	173	3	.	.	PUNCT
admet-797	174	1	summary	summary	NOUN
admet-797	174	2	of	of	ADP
admet-797	174	3	food	food	NOUN
admet-797	174	4	and	and	CCONJ
admet-797	174	5	milk	milk	NOUN
admet-797	174	6	effects	effect	NOUN
admet-797	174	7	on	on	ADP
admet-797	174	8	bioavailability	bioavailability	NOUN
admet-797	174	9	of	of	ADP
admet-797	174	10	tetracyclines	tetracycline	NOUN
admet-797	174	11	drugs	drug	NOUN
admet-797	174	12	percentage	percentage	NOUN
admet-797	174	13	absorption	absorption	NOUN
admet-797	174	14	,	,	PUNCT
admet-797	174	15	%	%	INTJ
admet-797	174	16	a	a	DET
admet-797	174	17	bioavailability	bioavailability	NOUN
admet-797	174	18	reduction	reduction	NOUN
admet-797	174	19	,	,	PUNCT
admet-797	174	20	%	%	NOUN
admet-797	174	21	b	b	NUM
admet-797	174	22	references	reference	NOUN
admet-797	174	23	for	for	ADP
admet-797	174	24	food	food	NOUN
admet-797	174	25	and	and	CCONJ
admet-797	174	26	milk	milk	NOUN
admet-797	174	27	effect	effect	NOUN
admet-797	174	28	food	food	NOUN
admet-797	174	29	milk	milk	NOUN
admet-797	174	30	ctc	ctc	PROPN
admet-797	174	31	25–30	25–30	PROPN
admet-797	174	32	45	45	NUM
admet-797	174	33	c	c	NOUN
admet-797	174	34	na	na	NOUN
admet-797	174	35	d	d	NOUN
admet-797	175	1	[	[	X
admet-797	175	2	9	9	NUM
admet-797	175	3	]	]	PUNCT
admet-797	175	4	dmctc	dmctc	ADV
admet-797	175	5	66	66	NUM
admet-797	175	6	na	na	NOUN
admet-797	175	7	d	d	PROPN
admet-797	175	8	70	70	NUM
admet-797	176	1	[	[	X
admet-797	176	2	6	6	NUM
admet-797	176	3	]	]	PUNCT
admet-797	176	4	doxy	doxy	PROPN
admet-797	176	5	95	95	NUM
admet-797	176	6	26	26	NUM
admet-797	176	7	(	(	PUNCT
admet-797	176	8	3	3	NUM
admet-797	176	9	-	-	SYM
admet-797	176	10	49	49	NUM
admet-797	176	11	)	)	PUNCT
admet-797	176	12	30	30	NUM
admet-797	176	13	(	(	PUNCT
admet-797	176	14	9	9	NUM
admet-797	176	15	-	-	SYM
admet-797	176	16	53	53	NUM
admet-797	176	17	)	)	PUNCT
admet-797	177	1	[	[	X
admet-797	177	2	10	10	NUM
admet-797	177	3	]	]	PUNCT
admet-797	177	4	mino	mino	NOUN
admet-797	177	5	95	95	NUM
admet-797	177	6	-	-	SYM
admet-797	177	7	100	100	NUM
admet-797	177	8	14	14	NUM
admet-797	177	9	(	(	PUNCT
admet-797	177	10	2	2	NUM
admet-797	177	11	-	-	SYM
admet-797	177	12	51	51	NUM
admet-797	177	13	)	)	PUNCT
admet-797	177	14	27	27	NUM
admet-797	177	15	(	(	PUNCT
admet-797	177	16	8	8	NUM
admet-797	177	17	-	-	SYM
admet-797	177	18	61	61	NUM
admet-797	177	19	)	)	PUNCT
admet-797	178	1	[	[	X
admet-797	178	2	6,9,10	6,9,10	NUM
admet-797	178	3	]	]	X
admet-797	178	4	oxy	oxy	NOUN
admet-797	178	5	58	58	NUM
admet-797	178	6	41	41	NUM
admet-797	178	7	(	(	PUNCT
admet-797	178	8	4	4	NUM
admet-797	178	9	-	-	NUM
admet-797	178	10	77	77	NUM
admet-797	178	11	)	)	PUNCT
admet-797	178	12	,	,	PUNCT
admet-797	178	13	0	0	NUM
admet-797	179	1	c	c	X
admet-797	179	2	,	,	PUNCT
admet-797	179	3	e	e	X
admet-797	179	4	83	83	NUM
admet-797	179	5	(	(	PUNCT
admet-797	179	6	45	45	NUM
admet-797	179	7	-	-	SYM
admet-797	179	8	96	96	NUM
admet-797	179	9	)	)	PUNCT
admet-797	180	1	[	[	X
admet-797	180	2	6,9,10	6,9,10	NUM
admet-797	180	3	]	]	X
admet-797	180	4	tc	tc	NOUN
admet-797	180	5	77–88	77–88	NUM
admet-797	180	6	46	46	NUM
admet-797	180	7	(	(	PUNCT
admet-797	180	8	13	13	NUM
admet-797	180	9	-	-	SYM
admet-797	180	10	73	73	NUM
admet-797	180	11	%	%	NOUN
admet-797	180	12	)	)	PUNCT
admet-797	180	13	,	,	PUNCT
admet-797	180	14	72	72	NUM
admet-797	180	15	c	c	NOUN
admet-797	180	16	65	65	NUM
admet-797	181	1	[	[	X
admet-797	181	2	5,8–10	5,8–10	NUM
admet-797	181	3	]	]	PUNCT
admet-797	181	4	a	a	DET
admet-797	181	5	ref	ref	NOUN
admet-797	181	6	.	.	PUNCT
admet-797	182	1	[	[	X
admet-797	182	2	4	4	NUM
admet-797	182	3	]	]	PUNCT
admet-797	182	4	;	;	PUNCT
admet-797	182	5	b	b	X
admet-797	182	6	in	in	ADP
admet-797	182	7	humans	human	NOUN
admet-797	182	8	unless	unless	SCONJ
admet-797	182	9	otherwise	otherwise	ADV
admet-797	182	10	noted	note	VERB
admet-797	182	11	;	;	PUNCT
admet-797	182	12	c	c	X
admet-797	182	13	in	in	ADP
admet-797	182	14	pigs	pig	NOUN
admet-797	182	15	;	;	PUNCT
admet-797	182	16	d	d	X
admet-797	182	17	data	datum	NOUN
admet-797	182	18	not	not	PART
admet-797	182	19	available	available	ADJ
admet-797	182	20	in	in	ADP
admet-797	182	21	the	the	DET
admet-797	182	22	literature	literature	NOUN
admet-797	182	23	;	;	PUNCT
admet-797	182	24	e	e	X
admet-797	182	25	low	low	ADJ
admet-797	182	26	bioavailability	bioavailability	NOUN
admet-797	182	27	(	(	PUNCT
admet-797	182	28	3	3	NUM
admet-797	182	29	%	%	NOUN
admet-797	182	30	in	in	ADP
admet-797	182	31	both	both	PRON
admet-797	182	32	fasted	fast	VERB
admet-797	182	33	and	and	CCONJ
admet-797	182	34	fed	feed	VERB
admet-797	182	35	pigs	pig	NOUN
admet-797	182	36	)	)	PUNCT
admet-797	182	37	we	we	PRON
admet-797	182	38	could	could	AUX
admet-797	182	39	not	not	PART
admet-797	182	40	find	find	VERB
admet-797	182	41	any	any	DET
admet-797	182	42	plausible	plausible	ADJ
admet-797	182	43	chemical	chemical	ADJ
admet-797	182	44	structural	structural	ADJ
admet-797	182	45	elucidation	elucidation	NOUN
admet-797	182	46	for	for	ADP
admet-797	182	47	the	the	DET
admet-797	182	48	differences	difference	NOUN
admet-797	182	49	among	among	ADP
admet-797	182	50	tetracyclines	tetracycline	NOUN
admet-797	182	51	regarding	regard	VERB
admet-797	182	52	the	the	DET
admet-797	182	53	effects	effect	NOUN
admet-797	182	54	of	of	ADP
admet-797	182	55	ca2	ca2	PROPN
admet-797	182	56	+	+	PROPN
admet-797	182	57	and	and	CCONJ
admet-797	182	58	mg2	mg2	PROPN
admet-797	182	59	+	+	PROPN
admet-797	182	60	.	.	PUNCT
admet-797	183	1	tetracyclines	tetracycline	NOUN
admet-797	183	2	can	can	AUX
admet-797	183	3	easily	easily	ADV
admet-797	183	4	modify	modify	VERB
admet-797	183	5	their	their	PRON
admet-797	183	6	tautomerism	tautomerism	NOUN
admet-797	183	7	in	in	ADP
admet-797	183	8	response	response	NOUN
admet-797	183	9	to	to	ADP
admet-797	183	10	various	various	ADJ
admet-797	183	11	chemical	chemical	ADJ
admet-797	183	12	environments	environment	NOUN
admet-797	183	13	[	[	X
admet-797	183	14	44	44	NUM
admet-797	183	15	]	]	PUNCT
admet-797	183	16	.	.	PUNCT
admet-797	184	1	metal	metal	NOUN
admet-797	184	2	binding	bind	VERB
admet-797	184	3	to	to	ADP
admet-797	184	4	anionic	anionic	ADJ
admet-797	184	5	phospholipids	phospholipid	NOUN
admet-797	184	6	in	in	ADP
admet-797	184	7	the	the	DET
admet-797	184	8	sl	sl	NOUN
admet-797	184	9	-	-	PUNCT
admet-797	184	10	pampa	pampa	NOUN
admet-797	184	11	membrane	membrane	NOUN
admet-797	184	12	may	may	AUX
admet-797	184	13	be	be	AUX
admet-797	184	14	another	another	DET
admet-797	184	15	possible	possible	ADJ
admet-797	184	16	mechanism	mechanism	NOUN
admet-797	184	17	to	to	PART
admet-797	184	18	reduce	reduce	VERB
admet-797	184	19	the	the	DET
admet-797	184	20	permeation	permeation	NOUN
admet-797	184	21	of	of	ADP
admet-797	184	22	tetracyclines	tetracyclines	PROPN
admet-797	184	23	.	.	PUNCT
admet-797	185	1	in	in	ADP
admet-797	185	2	our	our	PRON
admet-797	185	3	previous	previous	ADJ
admet-797	185	4	study	study	NOUN
admet-797	185	5	,	,	PUNCT
admet-797	185	6	the	the	DET
admet-797	185	7	addition	addition	NOUN
admet-797	185	8	of	of	ADP
admet-797	185	9	an	an	DET
admet-797	185	10	anionic	anionic	ADJ
admet-797	185	11	lipid	lipid	NOUN
admet-797	185	12	neutralizer	neutralizer	NOUN
admet-797	185	13	(	(	PUNCT
admet-797	185	14	tetrahexylammonium	tetrahexylammonium	NOUN
admet-797	185	15	)	)	PUNCT
admet-797	185	16	did	do	AUX
admet-797	185	17	not	not	PART
admet-797	185	18	affect	affect	VERB
admet-797	185	19	the	the	DET
admet-797	185	20	permeation	permeation	NOUN
admet-797	185	21	of	of	ADP
admet-797	185	22	tc	tc	NOUN
admet-797	185	23	in	in	ADP
admet-797	185	24	slpampa	slpampa	NOUN
admet-797	185	25	,	,	PUNCT
admet-797	185	26	suggesting	suggest	VERB
admet-797	185	27	that	that	SCONJ
admet-797	185	28	the	the	DET
admet-797	185	29	ionic	ionic	ADJ
admet-797	185	30	interaction	interaction	NOUN
admet-797	185	31	with	with	ADP
admet-797	185	32	anionic	anionic	ADJ
admet-797	185	33	phospholipids	phospholipid	NOUN
admet-797	185	34	do	do	AUX
admet-797	185	35	not	not	PART
admet-797	185	36	facilitate	facilitate	VERB
admet-797	185	37	the	the	DET
admet-797	185	38	permeation	permeation	NOUN
admet-797	185	39	of	of	ADP
admet-797	185	40	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	185	41	kiyohiko	kiyohiko	PROPN
admet-797	186	1	sugano	sugano	PROPN
admet-797	186	2	et	et	PROPN
admet-797	186	3	al	al	PROPN
admet-797	186	4	.	.	PROPN
admet-797	186	5	admet	admet	PROPN
admet-797	186	6	&	&	CCONJ
admet-797	186	7	dmpk	dmpk	PROPN
admet-797	186	8	8(2	8(2	NUM
admet-797	186	9	)	)	PUNCT
admet-797	186	10	(	(	PUNCT
admet-797	186	11	2020	2020	NUM
admet-797	186	12	)	)	PUNCT
admet-797	186	13	129	129	NUM
admet-797	186	14	-	-	SYM
admet-797	186	15	138	138	NUM
admet-797	186	16	136	136	NUM
admet-797	186	17	tc	tc	NOUN
admet-797	186	18	[	[	X
admet-797	186	19	30	30	NUM
admet-797	186	20	]	]	PUNCT
admet-797	186	21	.	.	PUNCT
admet-797	187	1	further	further	ADJ
admet-797	187	2	investigation	investigation	NOUN
admet-797	187	3	is	be	AUX
admet-797	187	4	required	require	VERB
admet-797	187	5	to	to	PART
admet-797	187	6	clarify	clarify	VERB
admet-797	187	7	the	the	DET
admet-797	187	8	interactions	interaction	NOUN
admet-797	187	9	among	among	ADP
admet-797	187	10	tetracyclines	tetracycline	NOUN
admet-797	187	11	,	,	PUNCT
admet-797	187	12	metal	metal	NOUN
admet-797	187	13	ions	ion	NOUN
admet-797	187	14	,	,	PUNCT
admet-797	187	15	and	and	CCONJ
admet-797	187	16	phospholipids	phospholipid	NOUN
admet-797	187	17	.	.	PUNCT
admet-797	188	1	we	we	PRON
admet-797	188	2	are	be	AUX
admet-797	188	3	currently	currently	ADV
admet-797	188	4	investigating	investigate	VERB
admet-797	188	5	the	the	DET
admet-797	188	6	effects	effect	NOUN
admet-797	188	7	of	of	ADP
admet-797	188	8	metal	metal	NOUN
admet-797	188	9	ions	ion	NOUN
admet-797	188	10	on	on	ADP
admet-797	188	11	the	the	DET
admet-797	188	12	sl	sl	NOUN
admet-797	188	13	-	-	PUNCT
admet-797	188	14	pampa	pampa	NOUN
admet-797	188	15	permeation	permeation	NOUN
admet-797	188	16	of	of	ADP
admet-797	188	17	structurally	structurally	ADV
admet-797	188	18	diverse	diverse	ADJ
admet-797	188	19	drugs	drug	NOUN
admet-797	188	20	.	.	PUNCT
admet-797	189	1	conclusion	conclusion	NOUN
admet-797	189	2	in	in	ADP
admet-797	189	3	contrast	contrast	NOUN
admet-797	189	4	to	to	ADP
admet-797	189	5	the	the	DET
admet-797	189	6	previously	previously	ADV
admet-797	189	7	suggested	suggest	VERB
admet-797	189	8	mechanism	mechanism	NOUN
admet-797	190	1	[	[	X
admet-797	190	2	21,22	21,22	X
admet-797	190	3	]	]	X
admet-797	190	4	,	,	PUNCT
admet-797	190	5	in	in	ADP
admet-797	190	6	this	this	DET
admet-797	190	7	study	study	NOUN
admet-797	190	8	,	,	PUNCT
admet-797	190	9	ca	ca	PROPN
admet-797	190	10	2	2	NUM
admet-797	190	11	+	+	NUM
admet-797	190	12	chelate	chelate	NOUN
admet-797	190	13	formation	formation	NOUN
admet-797	190	14	decreased	decrease	VERB
admet-797	190	15	the	the	DET
admet-797	190	16	membrane	membrane	NOUN
admet-797	190	17	permeation	permeation	NOUN
admet-797	190	18	of	of	ADP
admet-797	190	19	tetracyclines	tetracycline	NOUN
admet-797	190	20	,	,	PUNCT
admet-797	190	21	irrespective	irrespective	ADV
admet-797	190	22	of	of	ADP
admet-797	190	23	ca	ca	PROPN
admet-797	190	24	2	2	NUM
admet-797	190	25	+	+	CCONJ
admet-797	190	26	linked	link	VERB
admet-797	190	27	mucin	mucin	NOUN
admet-797	190	28	binding	bind	VERB
admet-797	190	29	.	.	PUNCT
admet-797	191	1	ca	can	AUX
admet-797	191	2	2	2	NUM
admet-797	191	3	+	+	NUM
admet-797	191	4	affected	affect	VERB
admet-797	191	5	the	the	DET
admet-797	191	6	pe	pe	PROPN
admet-797	191	7	values	value	NOUN
admet-797	191	8	in	in	ADP
admet-797	191	9	sl	sl	PROPN
admet-797	191	10	–	–	PUNCT
admet-797	191	11	pampa	pampa	PROPN
admet-797	191	12	and	and	CCONJ
admet-797	191	13	oct	oct	PROPN
admet-797	191	14	–	–	PUNCT
admet-797	191	15	pampa	pampa	NOUN
admet-797	191	16	in	in	ADP
admet-797	191	17	the	the	DET
admet-797	191	18	opposite	opposite	ADJ
admet-797	191	19	direction	direction	NOUN
admet-797	191	20	for	for	ADP
admet-797	191	21	some	some	DET
admet-797	191	22	tetracyclines	tetracycline	NOUN
admet-797	191	23	.	.	PUNCT
admet-797	192	1	sl	sl	PROPN
admet-797	192	2	–	–	PUNCT
admet-797	192	3	pampa	pampa	NOUN
admet-797	192	4	can	can	AUX
admet-797	192	5	be	be	AUX
admet-797	192	6	a	a	DET
admet-797	192	7	simple	simple	ADJ
admet-797	192	8	tool	tool	NOUN
admet-797	192	9	to	to	PART
admet-797	192	10	qualitatively	qualitatively	ADV
admet-797	192	11	evaluate	evaluate	VERB
admet-797	192	12	the	the	DET
admet-797	192	13	effect	effect	NOUN
admet-797	192	14	of	of	ADP
admet-797	192	15	multivalent	multivalent	NOUN
admet-797	192	16	metal	metal	NOUN
admet-797	192	17	ions	ion	NOUN
admet-797	192	18	on	on	ADP
admet-797	192	19	the	the	DET
admet-797	192	20	membrane	membrane	NOUN
admet-797	192	21	permeation	permeation	NOUN
admet-797	192	22	of	of	ADP
admet-797	192	23	drugs	drug	NOUN
admet-797	192	24	.	.	PUNCT
admet-797	193	1	conflict	conflict	NOUN
admet-797	193	2	of	of	ADP
admet-797	193	3	interest	interest	NOUN
admet-797	193	4	:	:	PUNCT
admet-797	193	5	the	the	DET
admet-797	193	6	authors	author	NOUN
admet-797	193	7	declare	declare	VERB
admet-797	193	8	no	no	DET
admet-797	193	9	conflict	conflict	NOUN
admet-797	193	10	of	of	ADP
admet-797	193	11	interest	interest	NOUN
admet-797	193	12	.	.	PUNCT
admet-797	194	1	references	reference	NOUN
admet-797	194	2	[	[	X
admet-797	194	3	1	1	NUM
admet-797	194	4	]	]	X
admet-797	194	5	b.m	b.m	PROPN
admet-797	194	6	.	.	PROPN
admet-797	194	7	lomaestro	lomaestro	PROPN
admet-797	194	8	,	,	PUNCT
admet-797	194	9	g.r	g.r	PROPN
admet-797	194	10	.	.	PROPN
admet-797	194	11	bailie	bailie	PROPN
admet-797	194	12	.	.	PUNCT
admet-797	195	1	absorption	absorption	NOUN
admet-797	195	2	interactions	interaction	NOUN
admet-797	195	3	with	with	ADP
admet-797	195	4	fluoroquinolones	fluoroquinolone	NOUN
admet-797	195	5	.	.	PUNCT
admet-797	196	1	drug	drug	PROPN
admet-797	196	2	saf	saf	PROPN
admet-797	196	3	.	.	PROPN
admet-797	196	4	12	12	NUM
admet-797	196	5	(	(	PUNCT
admet-797	196	6	1995	1995	NUM
admet-797	196	7	)	)	PUNCT
admet-797	196	8	314	314	NUM
admet-797	196	9	–	–	PUNCT
admet-797	196	10	333	333	NUM
admet-797	196	11	.	.	PUNCT
admet-797	197	1	[	[	X
admet-797	197	2	2	2	NUM
admet-797	197	3	]	]	X
admet-797	197	4	r.	r.	PROPN
admet-797	197	5	krishna	krishna	PROPN
admet-797	197	6	,	,	PUNCT
admet-797	197	7	l.	l.	PROPN
admet-797	197	8	east	east	PROPN
admet-797	197	9	,	,	PUNCT
admet-797	197	10	p.	p.	PROPN
admet-797	197	11	larson	larson	PROPN
admet-797	197	12	,	,	PUNCT
admet-797	197	13	c.	c.	PROPN
admet-797	197	14	valiathan	valiathan	PROPN
admet-797	197	15	,	,	PUNCT
admet-797	197	16	k.	k.	PROPN
admet-797	197	17	butterfield	butterfield	PROPN
admet-797	197	18	,	,	PUNCT
admet-797	197	19	y.	y.	PROPN
admet-797	197	20	teng	teng	PROPN
admet-797	197	21	,	,	PUNCT
admet-797	197	22	m.	m.	PROPN
admet-797	197	23	hernandez	hernandez	PROPN
admet-797	197	24	-	-	PUNCT
admet-797	197	25	illas	illas	PROPN
admet-797	197	26	.	.	PUNCT
admet-797	198	1	effect	effect	NOUN
admet-797	198	2	of	of	ADP
admet-797	198	3	metalcation	metalcation	NOUN
admet-797	198	4	antacids	antacid	NOUN
admet-797	198	5	on	on	ADP
admet-797	198	6	the	the	DET
admet-797	198	7	pharmacokinetics	pharmacokinetic	NOUN
admet-797	198	8	of	of	ADP
admet-797	198	9	1200	1200	NUM
admet-797	198	10	mg	mg	NUM
admet-797	198	11	raltegravir	raltegravir	PROPN
admet-797	198	12	.	.	PUNCT
admet-797	199	1	j.	j.	PROPN
admet-797	199	2	pharm	pharm	PROPN
admet-797	199	3	.	.	PUNCT
admet-797	200	1	pharmacol	pharmacol	PROPN
admet-797	200	2	.	.	PUNCT
admet-797	201	1	68	68	NUM
admet-797	201	2	(	(	PUNCT
admet-797	201	3	2016	2016	NUM
admet-797	201	4	)	)	PUNCT
admet-797	201	5	1359–1365	1359–1365	NOUN
admet-797	201	6	.	.	PUNCT
admet-797	202	1	[	[	X
admet-797	202	2	3	3	X
admet-797	202	3	]	]	X
admet-797	202	4	d.d	d.d	PROPN
admet-797	202	5	.	.	PROPN
admet-797	202	6	williams	williams	PROPN
admet-797	202	7	,	,	PUNCT
admet-797	202	8	b.	b.	PROPN
admet-797	202	9	peng	peng	PROPN
admet-797	202	10	,	,	PUNCT
admet-797	202	11	c.k	c.k	PROPN
admet-797	202	12	.	.	PROPN
admet-797	202	13	bailey	bailey	PROPN
admet-797	202	14	,	,	PUNCT
admet-797	202	15	m.b	m.b	PROPN
admet-797	202	16	.	.	PROPN
admet-797	202	17	wire	wire	NOUN
admet-797	202	18	,	,	PUNCT
admet-797	202	19	y.	y.	PROPN
admet-797	202	20	deng	deng	PROPN
admet-797	202	21	,	,	PUNCT
admet-797	202	22	j.w	j.w	PROPN
admet-797	202	23	.	.	PROPN
admet-797	202	24	park	park	PROPN
admet-797	202	25	,	,	PUNCT
admet-797	202	26	d.a	d.a	PROPN
admet-797	202	27	.	.	PROPN
admet-797	202	28	collins	collins	PROPN
admet-797	202	29	,	,	PUNCT
admet-797	202	30	s.g	s.g	PROPN
admet-797	202	31	.	.	PROPN
admet-797	202	32	kapsi	kapsi	PROPN
admet-797	202	33	,	,	PUNCT
admet-797	202	34	j.m	j.m	PROPN
admet-797	202	35	.	.	PROPN
admet-797	202	36	jenkins	jenkins	PROPN
admet-797	202	37	.	.	PUNCT
admet-797	203	1	effects	effect	NOUN
admet-797	203	2	of	of	ADP
admet-797	203	3	food	food	NOUN
admet-797	203	4	and	and	CCONJ
admet-797	203	5	antacids	antacid	NOUN
admet-797	203	6	on	on	ADP
admet-797	203	7	the	the	DET
admet-797	203	8	pharmacokinetics	pharmacokinetic	NOUN
admet-797	203	9	of	of	ADP
admet-797	203	10	eltrombopag	eltrombopag	NOUN
admet-797	203	11	in	in	ADP
admet-797	203	12	healthy	healthy	ADJ
admet-797	203	13	adult	adult	NOUN
admet-797	203	14	subjects	subject	NOUN
admet-797	203	15	:	:	PUNCT
admet-797	203	16	two	two	NUM
admet-797	203	17	single	single	ADJ
admet-797	203	18	-	-	PUNCT
admet-797	203	19	dose	dose	NOUN
admet-797	203	20	,	,	PUNCT
admet-797	203	21	open	open	ADJ
admet-797	203	22	-	-	PUNCT
admet-797	203	23	label	label	NOUN
admet-797	203	24	,	,	PUNCT
admet-797	203	25	randomized	randomize	VERB
admet-797	203	26	-	-	PUNCT
admet-797	203	27	sequence	sequence	NOUN
admet-797	203	28	,	,	PUNCT
admet-797	203	29	crossover	crossover	ADP
admet-797	203	30	studies	study	NOUN
admet-797	203	31	.	.	PUNCT
admet-797	204	1	clin	clin	PROPN
admet-797	204	2	.	.	PUNCT
admet-797	205	1	ther	ther	PROPN
admet-797	205	2	.	.	PUNCT
admet-797	206	1	31	31	NUM
admet-797	206	2	(	(	PUNCT
admet-797	206	3	2009	2009	NUM
admet-797	206	4	)	)	PUNCT
admet-797	207	1	764–776	764–776	NUM
admet-797	207	2	.	.	PUNCT
admet-797	208	1	[	[	X
admet-797	208	2	4	4	NUM
admet-797	208	3	]	]	X
admet-797	208	4	k.n	k.n	PROPN
admet-797	208	5	.	.	PROPN
admet-797	208	6	agwuh	agwuh	PROPN
admet-797	208	7	,	,	PUNCT
admet-797	208	8	a.	a.	PROPN
admet-797	208	9	macgowan	macgowan	PROPN
admet-797	208	10	.	.	PUNCT
admet-797	209	1	pharmacokinetics	pharmacokinetic	NOUN
admet-797	209	2	and	and	CCONJ
admet-797	209	3	pharmacodynamics	pharmacodynamic	NOUN
admet-797	209	4	of	of	ADP
admet-797	209	5	the	the	DET
admet-797	209	6	tetracyclines	tetracycline	NOUN
admet-797	209	7	including	include	VERB
admet-797	209	8	glycylcyclines	glycylcycline	NOUN
admet-797	209	9	.	.	PUNCT
admet-797	210	1	j.	j.	PROPN
admet-797	210	2	antimicrob	antimicrob	PROPN
admet-797	210	3	.	.	PUNCT
admet-797	211	1	chemother	chemother	PROPN
admet-797	211	2	.	.	PUNCT
admet-797	212	1	58	58	NUM
admet-797	212	2	(	(	PUNCT
admet-797	212	3	2006	2006	NUM
admet-797	212	4	)	)	PUNCT
admet-797	212	5	256–265	256–265	NUM
admet-797	212	6	.	.	PUNCT
admet-797	213	1	[	[	X
admet-797	213	2	5	5	X
admet-797	213	3	]	]	PUNCT
admet-797	213	4	h.	h.	PROPN
admet-797	213	5	jung	jung	PROPN
admet-797	213	6	,	,	PUNCT
admet-797	213	7	a.a	a.a	PROPN
admet-797	213	8	.	.	PROPN
admet-797	213	9	peregrina	peregrina	PROPN
admet-797	213	10	,	,	PUNCT
admet-797	213	11	j.m	j.m	PROPN
admet-797	213	12	.	.	PROPN
admet-797	213	13	rodriguez	rodriguez	PROPN
admet-797	213	14	,	,	PUNCT
admet-797	213	15	r.	r.	PROPN
admet-797	213	16	moreno	moreno	PROPN
admet-797	213	17	-	-	PUNCT
admet-797	213	18	esparza	esparza	PROPN
admet-797	213	19	.	.	PUNCT
admet-797	214	1	the	the	DET
admet-797	214	2	influence	influence	NOUN
admet-797	214	3	of	of	ADP
admet-797	214	4	coffee	coffee	NOUN
admet-797	214	5	with	with	ADP
admet-797	214	6	milk	milk	NOUN
admet-797	214	7	and	and	CCONJ
admet-797	214	8	tea	tea	NOUN
admet-797	214	9	with	with	ADP
admet-797	214	10	milk	milk	NOUN
admet-797	214	11	on	on	ADP
admet-797	214	12	the	the	DET
admet-797	214	13	bioavailability	bioavailability	NOUN
admet-797	214	14	of	of	ADP
admet-797	214	15	tetracycline	tetracycline	NOUN
admet-797	214	16	.	.	PUNCT
admet-797	215	1	biopharm	biopharm	NOUN
admet-797	215	2	.	.	PUNCT
admet-797	216	1	drug	drug	PROPN
admet-797	216	2	dispos	dispos	PROPN
admet-797	216	3	.	.	PUNCT
admet-797	217	1	18	18	NUM
admet-797	217	2	(	(	PUNCT
admet-797	217	3	1997	1997	NUM
admet-797	217	4	)	)	PUNCT
admet-797	218	1	459–463	459–463	NUM
admet-797	218	2	.	.	PUNCT
admet-797	219	1	[	[	X
admet-797	219	2	6	6	NUM
admet-797	219	3	]	]	X
admet-797	219	4	j.j	j.j	PROPN
admet-797	219	5	.	.	PROPN
admet-797	219	6	leyden	leyden	PROPN
admet-797	219	7	.	.	PUNCT
admet-797	220	1	absorption	absorption	NOUN
admet-797	220	2	of	of	ADP
admet-797	220	3	minocycline	minocycline	ADJ
admet-797	220	4	hydrochloride	hydrochloride	NOUN
admet-797	220	5	and	and	CCONJ
admet-797	220	6	tetracycline	tetracycline	VERB
admet-797	220	7	hydrochloride	hydrochloride	NOUN
admet-797	220	8	:	:	PUNCT
admet-797	220	9	effect	effect	NOUN
admet-797	220	10	of	of	ADP
admet-797	220	11	food	food	NOUN
admet-797	220	12	,	,	PUNCT
admet-797	220	13	milk	milk	NOUN
admet-797	220	14	,	,	PUNCT
admet-797	220	15	and	and	CCONJ
admet-797	220	16	iron	iron	NOUN
admet-797	220	17	.	.	PUNCT
admet-797	221	1	j.	j.	PROPN
admet-797	221	2	am	am	PROPN
admet-797	221	3	.	.	PUNCT
admet-797	222	1	acad	acad	PROPN
admet-797	222	2	.	.	PUNCT
admet-797	223	1	dermatol	dermatol	NOUN
admet-797	223	2	.	.	PUNCT
admet-797	224	1	12	12	NUM
admet-797	224	2	(	(	PUNCT
admet-797	224	3	1985	1985	NUM
admet-797	224	4	)	)	PUNCT
admet-797	225	1	308–312	308–312	NUM
admet-797	225	2	.	.	PUNCT
admet-797	226	1	[	[	X
admet-797	226	2	7	7	X
admet-797	226	3	]	]	X
admet-797	226	4	bioavailability	bioavailability	NOUN
admet-797	226	5	of	of	ADP
admet-797	226	6	tetracycline	tetracycline	NOUN
admet-797	226	7	and	and	CCONJ
admet-797	226	8	doxycycline	doxycycline	NOUN
admet-797	226	9	in	in	ADP
admet-797	226	10	fasted	fast	VERB
admet-797	226	11	and	and	CCONJ
admet-797	226	12	nonfasted	nonfasted	ADJ
admet-797	226	13	subjects	subject	NOUN
admet-797	226	14	.	.	PUNCT
admet-797	227	1	antimicrob	antimicrob	ADJ
admet-797	227	2	.	.	PUNCT
admet-797	228	1	agents	agent	NOUN
admet-797	228	2	chemother	chemother	PROPN
admet-797	228	3	.	.	PUNCT
admet-797	229	1	11	11	NUM
admet-797	229	2	(	(	PUNCT
admet-797	229	3	1977	1977	NUM
admet-797	229	4	)	)	PUNCT
admet-797	230	1	462–469	462–469	NUM
admet-797	230	2	.	.	PUNCT
admet-797	231	1	[	[	X
admet-797	231	2	8	8	NUM
admet-797	231	3	]	]	X
admet-797	231	4	h.j	h.j	PROPN
admet-797	231	5	.	.	PROPN
admet-797	231	6	cook	cook	PROPN
admet-797	231	7	,	,	PUNCT
admet-797	231	8	c.r	c.r	PROPN
admet-797	231	9	.	.	PROPN
admet-797	231	10	mundo	mundo	PROPN
admet-797	231	11	,	,	PUNCT
admet-797	231	12	l.	l.	PROPN
admet-797	231	13	fonseca	fonseca	PROPN
admet-797	231	14	.	.	PUNCT
admet-797	232	1	influence	influence	NOUN
admet-797	232	2	of	of	ADP
admet-797	232	3	the	the	DET
admet-797	232	4	diet	diet	NOUN
admet-797	232	5	on	on	ADP
admet-797	232	6	bioavailability	bioavailability	NOUN
admet-797	232	7	of	of	ADP
admet-797	232	8	tetracycline	tetracycline	NOUN
admet-797	232	9	.	.	PUNCT
admet-797	233	1	biopharm	biopharm	NOUN
admet-797	233	2	.	.	PUNCT
admet-797	234	1	drug	drug	PROPN
admet-797	234	2	dispos	dispos	PROPN
admet-797	234	3	.	.	PUNCT
admet-797	235	1	14	14	NUM
admet-797	235	2	(	(	PUNCT
admet-797	235	3	1993	1993	NUM
admet-797	235	4	)	)	PUNCT
admet-797	236	1	549–553	549–553	NUM
admet-797	236	2	.	.	PUNCT
admet-797	237	1	[	[	X
admet-797	237	2	9	9	NUM
admet-797	237	3	]	]	PUNCT
admet-797	237	4	p.	p.	PROPN
admet-797	237	5	nielsen	nielsen	PROPN
admet-797	237	6	,	,	PUNCT
admet-797	237	7	n.	n.	PROPN
admet-797	237	8	gyrd	gyrd	PROPN
admet-797	237	9	-	-	PUNCT
admet-797	237	10	hansen	hansen	PROPN
admet-797	237	11	.	.	PUNCT
admet-797	238	1	bioavailability	bioavailability	NOUN
admet-797	238	2	of	of	ADP
admet-797	238	3	oxytetracycline	oxytetracycline	NOUN
admet-797	238	4	,	,	PUNCT
admet-797	238	5	tetracycline	tetracycline	NOUN
admet-797	238	6	and	and	CCONJ
admet-797	238	7	chlortetracycline	chlortetracycline	VERB
admet-797	238	8	after	after	ADP
admet-797	238	9	oral	oral	ADJ
admet-797	238	10	administration	administration	NOUN
admet-797	238	11	to	to	PART
admet-797	238	12	fed	fed	PROPN
admet-797	238	13	and	and	CCONJ
admet-797	238	14	fasted	fast	VERB
admet-797	238	15	pigs	pig	NOUN
admet-797	238	16	.	.	PUNCT
admet-797	239	1	j.	j.	PROPN
admet-797	239	2	vet	vet	PROPN
admet-797	239	3	.	.	PUNCT
admet-797	240	1	pharmacol	pharmacol	PROPN
admet-797	240	2	.	.	PUNCT
admet-797	241	1	ther	ther	PROPN
admet-797	241	2	.	.	PUNCT
admet-797	242	1	19	19	NUM
admet-797	242	2	(	(	PUNCT
admet-797	242	3	1996	1996	NUM
admet-797	242	4	)	)	PUNCT
admet-797	243	1	305–311	305–311	NUM
admet-797	243	2	.	.	PUNCT
admet-797	244	1	[	[	X
admet-797	244	2	10	10	NUM
admet-797	244	3	]	]	X
admet-797	244	4	f.p	f.p	PROPN
admet-797	244	5	.	.	PROPN
admet-797	244	6	meyer	meyer	PROPN
admet-797	244	7	.	.	PROPN
admet-797	244	8	minocycline	minocycline	PROPN
admet-797	244	9	for	for	ADP
admet-797	244	10	acne	acne	NOUN
admet-797	244	11	.	.	PUNCT
admet-797	245	1	food	food	NOUN
admet-797	245	2	reduces	reduce	VERB
admet-797	245	3	minocycline	minocycline	NOUN
admet-797	245	4	’s	’s	PART
admet-797	245	5	bioavailability	bioavailability	NOUN
admet-797	245	6	.	.	PUNCT
admet-797	246	1	bmj	bmj	PROPN
admet-797	246	2	br	br	PROPN
admet-797	246	3	.	.	PUNCT
admet-797	246	4	med	med	PROPN
admet-797	246	5	.	.	PUNCT
admet-797	247	1	j.	j.	PROPN
admet-797	247	2	312	312	NUM
admet-797	247	3	(	(	PUNCT
admet-797	247	4	1996	1996	NUM
admet-797	247	5	)	)	PUNCT
admet-797	247	6	1101	1101	NUM
admet-797	247	7	.	.	PUNCT
admet-797	248	1	[	[	X
admet-797	248	2	11	11	NUM
admet-797	248	3	]	]	X
admet-797	248	4	p.j	p.j	PROPN
admet-797	248	5	.	.	PROPN
admet-797	248	6	neuvonen	neuvonen	PROPN
admet-797	248	7	.	.	PUNCT
admet-797	249	1	interactions	interaction	NOUN
admet-797	249	2	with	with	ADP
admet-797	249	3	the	the	DET
admet-797	249	4	absorption	absorption	NOUN
admet-797	249	5	of	of	ADP
admet-797	249	6	tetracyclines	tetracyclines	PROPN
admet-797	249	7	.	.	PUNCT
admet-797	250	1	drugs	drug	NOUN
admet-797	250	2	.	.	PUNCT
admet-797	251	1	11	11	NUM
admet-797	251	2	(	(	PUNCT
admet-797	251	3	1976	1976	NUM
admet-797	251	4	)	)	PUNCT
admet-797	251	5	45–54	45–54	NUM
admet-797	251	6	.	.	PUNCT
admet-797	252	1	[	[	X
admet-797	252	2	12	12	NUM
admet-797	252	3	]	]	X
admet-797	252	4	a.h	a.h	PROPN
admet-797	252	5	.	.	PROPN
admet-797	252	6	caswell	caswell	PROPN
admet-797	252	7	,	,	PUNCT
admet-797	252	8	j.d	j.d	PROPN
admet-797	252	9	.	.	PROPN
admet-797	252	10	hutchison	hutchison	PROPN
admet-797	252	11	.	.	PUNCT
admet-797	253	1	selectivity	selectivity	NOUN
admet-797	253	2	of	of	ADP
admet-797	253	3	cation	cation	NOUN
admet-797	253	4	chelation	chelation	NOUN
admet-797	253	5	to	to	ADP
admet-797	253	6	tetracyclines	tetracycline	NOUN
admet-797	253	7	:	:	PUNCT
admet-797	253	8	evidence	evidence	NOUN
admet-797	253	9	for	for	ADP
admet-797	253	10	special	special	ADJ
admet-797	253	11	conformation	conformation	NOUN
admet-797	253	12	of	of	ADP
admet-797	253	13	calcium	calcium	NOUN
admet-797	253	14	chelate	chelate	NOUN
admet-797	253	15	.	.	PUNCT
admet-797	254	1	biochem	biochem	PROPN
admet-797	254	2	.	.	PUNCT
admet-797	255	1	biophys	biophy	NOUN
admet-797	255	2	.	.	PUNCT
admet-797	256	1	res	re	NOUN
admet-797	256	2	.	.	PUNCT
admet-797	257	1	commun	commun	PROPN
admet-797	257	2	.	.	PUNCT
admet-797	258	1	43	43	NUM
admet-797	258	2	(	(	PUNCT
admet-797	258	3	1971	1971	NUM
admet-797	258	4	)	)	PUNCT
admet-797	258	5	625–630	625–630	NUM
admet-797	258	6	.	.	PUNCT
admet-797	259	1	[	[	X
admet-797	259	2	13	13	NUM
admet-797	259	3	]	]	SYM
admet-797	259	4	k.w	k.w	PROPN
admet-797	259	5	.	.	PUNCT
admet-797	259	6	kohn	kohn	PROPN
admet-797	259	7	.	.	PUNCT
admet-797	260	1	mediation	mediation	NOUN
admet-797	260	2	of	of	ADP
admet-797	260	3	divalent	divalent	ADJ
admet-797	260	4	metal	metal	NOUN
admet-797	260	5	ions	ion	NOUN
admet-797	260	6	in	in	ADP
admet-797	260	7	the	the	DET
admet-797	260	8	binding	binding	NOUN
admet-797	260	9	of	of	ADP
admet-797	260	10	tetracycline	tetracycline	NOUN
admet-797	260	11	to	to	ADP
admet-797	260	12	macromolecules	macromolecule	NOUN
admet-797	260	13	.	.	PUNCT
admet-797	261	1	nature	nature	NOUN
admet-797	261	2	191	191	NUM
admet-797	261	3	(	(	PUNCT
admet-797	261	4	1961	1961	NUM
admet-797	261	5	)	)	PUNCT
admet-797	261	6	1156–1158	1156–1158	NUM
admet-797	261	7	.	.	PUNCT
admet-797	262	1	[	[	X
admet-797	262	2	14	14	NUM
admet-797	262	3	]	]	X
admet-797	262	4	l.	l.	PROPN
admet-797	262	5	lambs	lambs	PROPN
admet-797	262	6	,	,	PUNCT
admet-797	262	7	b.	b.	PROPN
admet-797	262	8	decock	decock	PROPN
admet-797	262	9	-	-	PUNCT
admet-797	262	10	le	le	X
admet-797	262	11	reverend	reverend	PROPN
admet-797	262	12	,	,	PUNCT
admet-797	262	13	h.	h.	PROPN
admet-797	262	14	kozlowski	kozlowski	PROPN
admet-797	262	15	,	,	PUNCT
admet-797	262	16	g.	g.	PROPN
admet-797	262	17	berthon	berthon	PROPN
admet-797	262	18	.	.	PUNCT
admet-797	263	1	metal	metal	NOUN
admet-797	263	2	ion	ion	NOUN
admet-797	263	3	-	-	PUNCT
admet-797	263	4	tetracycline	tetracycline	NOUN
admet-797	263	5	interactions	interaction	NOUN
admet-797	263	6	in	in	ADP
admet-797	263	7	biological	biological	ADJ
admet-797	263	8	fluids	fluid	NOUN
admet-797	263	9	.	.	PUNCT
admet-797	264	1	9	9	X
admet-797	264	2	.	.	X
admet-797	264	3	circular	circular	ADJ
admet-797	264	4	dichroism	dichroism	NOUN
admet-797	264	5	spectra	spectra	NOUN
admet-797	264	6	of	of	ADP
admet-797	264	7	calcium	calcium	NOUN
admet-797	264	8	and	and	CCONJ
admet-797	264	9	magnesium	magnesium	NOUN
admet-797	264	10	complexes	complex	NOUN
admet-797	264	11	with	with	ADP
admet-797	264	12	tetracycline	tetracycline	NOUN
admet-797	264	13	,	,	PUNCT
admet-797	264	14	oxytetracycline	oxytetracycline	ADJ
admet-797	264	15	,	,	PUNCT
admet-797	264	16	doxycycline	doxycycline	NOUN
admet-797	264	17	,	,	PUNCT
admet-797	264	18	and	and	CCONJ
admet-797	264	19	chlortetracycline	chlortetracycline	VERB
admet-797	264	20	and	and	CCONJ
admet-797	264	21	discussion	discussion	NOUN
admet-797	264	22	of	of	ADP
admet-797	264	23	their	their	PRON
admet-797	264	24	binding	bind	VERB
admet-797	264	25	modes	mode	NOUN
admet-797	264	26	.	.	PUNCT
admet-797	265	1	inorg	inorg	PROPN
admet-797	265	2	.	.	PUNCT
admet-797	266	1	chem	chem	NOUN
admet-797	266	2	.	.	PUNCT
admet-797	267	1	27	27	NUM
admet-797	267	2	(	(	PUNCT
admet-797	267	3	1988	1988	NUM
admet-797	267	4	)	)	PUNCT
admet-797	267	5	3001–3012	3001–3012	NUM
admet-797	267	6	.	.	PUNCT
admet-797	268	1	[	[	X
admet-797	268	2	15	15	NUM
admet-797	268	3	]	]	X
admet-797	268	4	j.t	j.t	PROPN
admet-797	268	5	.	.	PROPN
admet-797	268	6	doluisio	doluisio	PROPN
admet-797	268	7	,	,	PUNCT
admet-797	268	8	a.n	a.n	PROPN
admet-797	268	9	.	.	PROPN
admet-797	268	10	martin	martin	PROPN
admet-797	268	11	.	.	PUNCT
admet-797	269	1	metal	metal	NOUN
admet-797	269	2	complexation	complexation	NOUN
admet-797	269	3	of	of	ADP
admet-797	269	4	the	the	DET
admet-797	269	5	tetracycline	tetracycline	NOUN
admet-797	269	6	hydrochlorides	hydrochloride	NOUN
admet-797	269	7	.	.	PUNCT
admet-797	270	1	j.	j.	PROPN
admet-797	270	2	med	med	PROPN
admet-797	270	3	.	.	PROPN
admet-797	270	4	chem	chem	PROPN
admet-797	270	5	.	.	PUNCT
admet-797	271	1	6	6	NUM
admet-797	271	2	(	(	PUNCT
admet-797	271	3	1963	1963	NUM
admet-797	271	4	)	)	PUNCT
admet-797	271	5	16–20	16–20	NUM
admet-797	271	6	.	.	PUNCT
admet-797	272	1	admet	admet	PROPN
admet-797	272	2	&	&	CCONJ
admet-797	272	3	dmpk	dmpk	PROPN
admet-797	272	4	8(2	8(2	NUM
admet-797	272	5	)	)	PUNCT
admet-797	272	6	(	(	PUNCT
admet-797	272	7	2020	2020	NUM
admet-797	272	8	)	)	PUNCT
admet-797	272	9	129	129	NUM
admet-797	272	10	-	-	SYM
admet-797	272	11	138	138	NUM
admet-797	272	12	effect	effect	NOUN
admet-797	272	13	of	of	ADP
admet-797	272	14	metal	metal	NOUN
admet-797	272	15	ions	ion	NOUN
admet-797	272	16	on	on	ADP
admet-797	272	17	pampa	pampa	PROPN
admet-797	272	18	permeation	permeation	NOUN
admet-797	272	19	of	of	ADP
admet-797	272	20	tetracyclines	tetracyclines	PROPN
admet-797	272	21	doi	doi	PROPN
admet-797	272	22	:	:	PUNCT
admet-797	272	23	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	NOUN
admet-797	272	24	137	137	NUM
admet-797	273	1	[	[	X
admet-797	273	2	16	16	NUM
admet-797	273	3	]	]	X
admet-797	273	4	m.o	m.o	PROPN
admet-797	273	5	.	.	PROPN
admet-797	273	6	schmitt	schmitt	PROPN
admet-797	273	7	,	,	PUNCT
admet-797	273	8	s.	s.	PROPN
admet-797	273	9	schneider	schneider	PROPN
admet-797	273	10	.	.	PUNCT
admet-797	274	1	spectroscopic	spectroscopic	ADJ
admet-797	274	2	investigation	investigation	NOUN
admet-797	274	3	of	of	ADP
admet-797	274	4	complexation	complexation	NOUN
admet-797	274	5	between	between	ADP
admet-797	274	6	various	various	ADJ
admet-797	274	7	tetracyclines	tetracycline	NOUN
admet-797	274	8	and	and	CCONJ
admet-797	274	9	mg	mg	PROPN
admet-797	274	10	2	2	NUM
admet-797	274	11	+	+	NUM
admet-797	274	12	or	or	CCONJ
admet-797	274	13	ca	ca	NOUN
admet-797	274	14	2	2	NUM
admet-797	274	15	+	+	NOUN
admet-797	274	16	.	.	PUNCT
admet-797	274	17	physchemcomm	physchemcomm	NOUN
admet-797	274	18	.	.	PUNCT
admet-797	275	1	3	3	NUM
admet-797	275	2	(	(	PUNCT
admet-797	275	3	2000	2000	NUM
admet-797	275	4	)	)	PUNCT
admet-797	275	5	42–55	42–55	NOUN
admet-797	275	6	.	.	PUNCT
admet-797	276	1	[	[	X
admet-797	276	2	17	17	NUM
admet-797	276	3	]	]	X
admet-797	276	4	r.	r.	PROPN
admet-797	276	5	pulicharla	pulicharla	PROPN
admet-797	276	6	,	,	PUNCT
admet-797	276	7	k.	k.	PROPN
admet-797	276	8	hegde	hegde	PROPN
admet-797	276	9	,	,	PUNCT
admet-797	276	10	s.k	s.k	PROPN
admet-797	276	11	.	.	PROPN
admet-797	276	12	brar	brar	PROPN
admet-797	276	13	,	,	PUNCT
admet-797	276	14	r.y	r.y	PROPN
admet-797	276	15	.	.	PROPN
admet-797	276	16	surampalli	surampalli	PROPN
admet-797	276	17	.	.	PUNCT
admet-797	277	1	tetracyclines	tetracycline	NOUN
admet-797	277	2	metal	metal	NOUN
admet-797	277	3	complexation	complexation	NOUN
admet-797	277	4	:	:	PUNCT
admet-797	277	5	significance	significance	NOUN
admet-797	277	6	and	and	CCONJ
admet-797	277	7	fate	fate	NOUN
admet-797	277	8	of	of	ADP
admet-797	277	9	mutual	mutual	ADJ
admet-797	277	10	existence	existence	NOUN
admet-797	277	11	in	in	ADP
admet-797	277	12	the	the	DET
admet-797	277	13	environment	environment	NOUN
admet-797	277	14	.	.	PUNCT
admet-797	278	1	environ	environ	PROPN
admet-797	278	2	.	.	PROPN
admet-797	278	3	pollut	pollut	PROPN
admet-797	278	4	.	.	PUNCT
admet-797	279	1	221	221	NUM
admet-797	279	2	(	(	PUNCT
admet-797	279	3	2017	2017	NUM
admet-797	279	4	)	)	PUNCT
admet-797	279	5	1–14	1–14	PROPN
admet-797	279	6	.	.	PUNCT
admet-797	280	1	[	[	X
admet-797	280	2	18	18	NUM
admet-797	280	3	]	]	X
admet-797	280	4	s.	s.	PROPN
admet-797	280	5	banerjee	banerjee	PROPN
admet-797	280	6	,	,	PUNCT
admet-797	280	7	k.	k.	PROPN
admet-797	280	8	chakrabarti	chakrabarti	PROPN
admet-797	280	9	.	.	PUNCT
admet-797	281	1	the	the	DET
admet-797	281	2	transport	transport	NOUN
admet-797	281	3	of	of	ADP
admet-797	281	4	tetracyclines	tetracycline	NOUN
admet-797	281	5	across	across	ADP
admet-797	281	6	the	the	DET
admet-797	281	7	mouse	mouse	NOUN
admet-797	281	8	ileum	ileum	NOUN
admet-797	281	9	in	in	ADP
admet-797	281	10	vitro	vitro	NOUN
admet-797	281	11	:	:	PUNCT
admet-797	281	12	the	the	DET
admet-797	281	13	effect	effect	NOUN
admet-797	281	14	of	of	ADP
admet-797	281	15	cations	cation	NOUN
admet-797	281	16	and	and	CCONJ
admet-797	281	17	other	other	ADJ
admet-797	281	18	agents	agent	NOUN
admet-797	281	19	.	.	PUNCT
admet-797	282	1	j.	j.	PROPN
admet-797	282	2	pharm	pharm	PROPN
admet-797	282	3	.	.	PUNCT
admet-797	283	1	pharmacol	pharmacol	PROPN
admet-797	283	2	.	.	PUNCT
admet-797	284	1	28	28	NUM
admet-797	284	2	(	(	PUNCT
admet-797	284	3	1976	1976	NUM
admet-797	284	4	)	)	PUNCT
admet-797	285	1	133–138	133–138	NUM
admet-797	285	2	.	.	PUNCT
admet-797	286	1	[	[	X
admet-797	286	2	19	19	NUM
admet-797	286	3	]	]	PUNCT
admet-797	286	4	h.	h.	PROPN
admet-797	286	5	poiger	poiger	PROPN
admet-797	286	6	,	,	PUNCT
admet-797	286	7	c.	c.	PROPN
admet-797	286	8	schlatter	schlatter	PROPN
admet-797	286	9	.	.	PUNCT
admet-797	286	10	interaction	interaction	NOUN
admet-797	286	11	of	of	ADP
admet-797	286	12	cations	cation	NOUN
admet-797	286	13	and	and	CCONJ
admet-797	286	14	chelators	chelator	NOUN
admet-797	286	15	with	with	ADP
admet-797	286	16	the	the	DET
admet-797	286	17	intestinal	intestinal	ADJ
admet-797	286	18	absorption	absorption	NOUN
admet-797	286	19	of	of	ADP
admet-797	286	20	tetracycline	tetracycline	NOUN
admet-797	286	21	.	.	PUNCT
admet-797	287	1	naunyn	naunyn	PROPN
admet-797	287	2	.	.	PUNCT
admet-797	288	1	schmiedebergs	schmiedebergs	PROPN
admet-797	288	2	.	.	PUNCT
admet-797	289	1	arch	arch	PROPN
admet-797	289	2	.	.	PUNCT
admet-797	290	1	pharmacol	pharmacol	NOUN
admet-797	290	2	.	.	PUNCT
admet-797	291	1	306	306	NUM
admet-797	291	2	(	(	PUNCT
admet-797	291	3	1979	1979	NUM
admet-797	291	4	)	)	PUNCT
admet-797	291	5	89–92	89–92	NUM
admet-797	291	6	.	.	PUNCT
admet-797	292	1	[	[	X
admet-797	292	2	20	20	NUM
admet-797	292	3	]	]	PUNCT
admet-797	292	4	l.	l.	PROPN
admet-797	292	5	v	v	PROPN
admet-797	292	6	allen	allen	PROPN
admet-797	292	7	jr	jr	PROPN
admet-797	292	8	,	,	PUNCT
admet-797	292	9	r.s	r.s	PROPN
admet-797	292	10	.	.	PROPN
admet-797	292	11	levinson	levinson	PROPN
admet-797	292	12	,	,	PUNCT
admet-797	292	13	c.	c.	PROPN
admet-797	292	14	robinson	robinson	PROPN
admet-797	292	15	,	,	PUNCT
admet-797	292	16	a.	a.	PROPN
admet-797	292	17	lau	lau	PROPN
admet-797	292	18	.	.	PUNCT
admet-797	293	1	effect	effect	NOUN
admet-797	293	2	of	of	ADP
admet-797	293	3	surfactant	surfactant	NOUN
admet-797	293	4	on	on	ADP
admet-797	293	5	tetracycline	tetracycline	PROPN
admet-797	293	6	absorption	absorption	NOUN
admet-797	293	7	across	across	ADP
admet-797	293	8	everted	everted	ADJ
admet-797	293	9	rat	rat	NOUN
admet-797	293	10	intestine	intestine	NOUN
admet-797	293	11	.	.	PUNCT
admet-797	294	1	j.	j.	PROPN
admet-797	294	2	pharm	pharm	PROPN
admet-797	294	3	.	.	PUNCT
admet-797	295	1	sci	sci	PROPN
admet-797	295	2	.	.	PROPN
admet-797	296	1	70	70	NUM
admet-797	296	2	(	(	PUNCT
admet-797	296	3	1981	1981	NUM
admet-797	296	4	)	)	PUNCT
admet-797	297	1	269–271	269–271	NUM
admet-797	297	2	.	.	PUNCT
admet-797	298	1	[	[	X
admet-797	298	2	21	21	NUM
admet-797	298	3	]	]	PUNCT
admet-797	298	4	k.	k.	PROPN
admet-797	298	5	kakemi	kakemi	PROPN
admet-797	298	6	,	,	PUNCT
admet-797	298	7	h.	h.	PROPN
admet-797	298	8	sezaki	sezaki	PROPN
admet-797	298	9	,	,	PUNCT
admet-797	298	10	h.	h.	PROPN
admet-797	298	11	ogata	ogata	PROPN
admet-797	298	12	,	,	PUNCT
admet-797	298	13	t.	t.	PROPN
admet-797	298	14	nadai	nadai	PROPN
admet-797	298	15	.	.	PUNCT
admet-797	299	1	absorption	absorption	NOUN
admet-797	299	2	and	and	CCONJ
admet-797	299	3	excretion	excretion	NOUN
admet-797	299	4	of	of	ADP
admet-797	299	5	drugs	drug	NOUN
admet-797	299	6	.	.	PUNCT
admet-797	300	1	xxxvi	xxxvi	NOUN
admet-797	300	2	.	.	PUNCT
admet-797	301	1	effect	effect	NOUN
admet-797	301	2	of	of	ADP
admet-797	301	3	ca2	ca2	PROPN
admet-797	301	4	+	+	X
admet-797	301	5	on	on	ADP
admet-797	301	6	the	the	DET
admet-797	301	7	absorption	absorption	NOUN
admet-797	301	8	of	of	ADP
admet-797	301	9	tetracycline	tetracycline	NOUN
admet-797	301	10	from	from	ADP
admet-797	301	11	the	the	DET
admet-797	301	12	small	small	ADJ
admet-797	301	13	intestine	intestine	NOUN
admet-797	301	14	(	(	PUNCT
admet-797	301	15	1	1	NUM
admet-797	301	16	)	)	PUNCT
admet-797	301	17	.	.	PUNCT
admet-797	302	1	chem	chem	NOUN
admet-797	302	2	.	.	PUNCT
admet-797	303	1	pharm	pharm	NOUN
admet-797	303	2	.	.	PUNCT
admet-797	304	1	bull	bull	NOUN
admet-797	304	2	.	.	PUNCT
admet-797	305	1	16	16	NUM
admet-797	305	2	(	(	PUNCT
admet-797	305	3	1968	1968	NUM
admet-797	305	4	)	)	PUNCT
admet-797	305	5	2200–2205	2200–2205	NUM
admet-797	305	6	.	.	PUNCT
admet-797	306	1	[	[	X
admet-797	306	2	22	22	NUM
admet-797	306	3	]	]	PUNCT
admet-797	306	4	k.	k.	PROPN
admet-797	306	5	kakemi	kakemi	PROPN
admet-797	306	6	,	,	PUNCT
admet-797	306	7	h.	h.	PROPN
admet-797	306	8	sezaki	sezaki	PROPN
admet-797	306	9	,	,	PUNCT
admet-797	306	10	m.	m.	PROPN
admet-797	306	11	hayashi	hayashi	PROPN
admet-797	306	12	,	,	PUNCT
admet-797	306	13	t.	t.	PROPN
admet-797	306	14	nadai	nadai	PROPN
admet-797	306	15	.	.	PUNCT
admet-797	307	1	absorption	absorption	NOUN
admet-797	307	2	and	and	CCONJ
admet-797	307	3	excretion	excretion	NOUN
admet-797	307	4	of	of	ADP
admet-797	307	5	drugs	drug	NOUN
admet-797	307	6	.	.	PUNCT
admet-797	308	1	xxxvii	xxxvii	PROPN
admet-797	308	2	.	.	PUNCT
admet-797	309	1	effect	effect	NOUN
admet-797	309	2	of	of	ADP
admet-797	309	3	ca2	ca2	PROPN
admet-797	309	4	+	+	X
admet-797	309	5	on	on	ADP
admet-797	309	6	the	the	DET
admet-797	309	7	absorption	absorption	NOUN
admet-797	309	8	of	of	ADP
admet-797	309	9	tetracycline	tetracycline	NOUN
admet-797	309	10	from	from	ADP
admet-797	309	11	the	the	DET
admet-797	309	12	small	small	ADJ
admet-797	309	13	intestine	intestine	NOUN
admet-797	309	14	(	(	PUNCT
admet-797	309	15	2	2	NUM
admet-797	309	16	)	)	PUNCT
admet-797	309	17	.	.	PUNCT
admet-797	310	1	chem	chem	NOUN
admet-797	310	2	.	.	PUNCT
admet-797	311	1	pharm	pharm	NOUN
admet-797	311	2	.	.	PUNCT
admet-797	312	1	bull	bull	NOUN
admet-797	312	2	.	.	PUNCT
admet-797	313	1	16	16	NUM
admet-797	313	2	(	(	PUNCT
admet-797	313	3	1968	1968	NUM
admet-797	313	4	)	)	PUNCT
admet-797	313	5	2206	2206	NUM
admet-797	313	6	–	–	PUNCT
admet-797	313	7	2212	2212	NUM
admet-797	313	8	.	.	PUNCT
admet-797	314	1	[	[	X
admet-797	314	2	23	23	NUM
admet-797	314	3	]	]	X
admet-797	314	4	g.e	g.e	PROPN
admet-797	314	5	.	.	PROPN
admet-797	314	6	schumacher	schumacher	PROPN
admet-797	314	7	,	,	PUNCT
admet-797	314	8	e.e	e.e	PROPN
admet-797	314	9	.	.	PROPN
admet-797	314	10	linn	linn	PROPN
admet-797	314	11	.	.	PUNCT
admet-797	315	1	kinetic	kinetic	ADJ
admet-797	315	2	and	and	CCONJ
admet-797	315	3	thermodynamic	thermodynamic	ADJ
admet-797	315	4	aspects	aspect	NOUN
admet-797	315	5	of	of	ADP
admet-797	315	6	in	in	ADP
admet-797	315	7	vitro	vitro	X
admet-797	315	8	interphase	interphase	NOUN
admet-797	315	9	transfer	transfer	NOUN
admet-797	315	10	of	of	ADP
admet-797	315	11	tetracyclines	tetracyclines	PROPN
admet-797	315	12	ii	ii	PROPN
admet-797	315	13	:	:	PUNCT
admet-797	315	14	influence	influence	NOUN
admet-797	315	15	of	of	ADP
admet-797	315	16	divalent	divalent	ADJ
admet-797	315	17	metal	metal	NOUN
admet-797	315	18	salts	salt	NOUN
admet-797	315	19	.	.	PUNCT
admet-797	316	1	j.	j.	PROPN
admet-797	316	2	pharm	pharm	PROPN
admet-797	316	3	.	.	PUNCT
admet-797	317	1	sci	sci	PROPN
admet-797	317	2	.	.	PROPN
admet-797	318	1	67	67	NUM
admet-797	318	2	(	(	PUNCT
admet-797	318	3	1978	1978	NUM
admet-797	318	4	)	)	PUNCT
admet-797	318	5	1717–1720	1717–1720	NUM
admet-797	318	6	.	.	PUNCT
admet-797	319	1	[	[	X
admet-797	319	2	24	24	NUM
admet-797	319	3	]	]	X
admet-797	319	4	p.l	p.l	PROPN
admet-797	319	5	.	.	PUNCT
admet-797	319	6	nicklin	nicklin	PROPN
admet-797	319	7	,	,	PUNCT
admet-797	319	8	w.j	w.j	PROPN
admet-797	319	9	.	.	PROPN
admet-797	319	10	irwin	irwin	PROPN
admet-797	319	11	,	,	PUNCT
admet-797	319	12	i.f	i.f	PROPN
admet-797	319	13	.	.	PUNCT
admet-797	320	1	hassan	hassan	PROPN
admet-797	320	2	,	,	PUNCT
admet-797	320	3	m.	m.	PROPN
admet-797	320	4	mackay	mackay	PROPN
admet-797	320	5	.	.	PUNCT
admet-797	321	1	development	development	NOUN
admet-797	321	2	of	of	ADP
admet-797	321	3	a	a	DET
admet-797	321	4	minimum	minimum	ADJ
admet-797	321	5	-	-	PUNCT
admet-797	321	6	calcium	calcium	NOUN
admet-797	321	7	caco-2	caco-2	NUM
admet-797	321	8	monolayer	monolayer	NOUN
admet-797	321	9	model	model	NOUN
admet-797	321	10	:	:	PUNCT
admet-797	321	11	calcium	calcium	NOUN
admet-797	321	12	and	and	CCONJ
admet-797	321	13	magnesium	magnesium	NOUN
admet-797	321	14	ions	ion	NOUN
admet-797	321	15	retard	retard	VERB
admet-797	321	16	the	the	DET
admet-797	321	17	transport	transport	NOUN
admet-797	321	18	of	of	ADP
admet-797	321	19	pamidronate	pamidronate	NOUN
admet-797	321	20	.	.	PUNCT
admet-797	322	1	int	int	NOUN
admet-797	322	2	.	.	PUNCT
admet-797	323	1	j.	j.	PROPN
admet-797	323	2	pharm	pharm	PROPN
admet-797	323	3	.	.	PUNCT
admet-797	324	1	123	123	NUM
admet-797	324	2	(	(	PUNCT
admet-797	324	3	1995	1995	NUM
admet-797	324	4	)	)	PUNCT
admet-797	324	5	187–197	187–197	NUM
admet-797	324	6	.	.	PUNCT
admet-797	325	1	[	[	X
admet-797	325	2	25	25	NUM
admet-797	325	3	]	]	X
admet-797	325	4	d.	d.	PROPN
admet-797	325	5	el	el	PROPN
admet-797	325	6	-	-	PUNCT
admet-797	325	7	sabawi	sabawi	PROPN
admet-797	325	8	,	,	PUNCT
admet-797	325	9	r.	r.	PROPN
admet-797	325	10	abu	abu	PROPN
admet-797	325	11	-	-	PUNCT
admet-797	325	12	dahab	dahab	PROPN
admet-797	325	13	,	,	PUNCT
admet-797	325	14	w.a	w.a	PROPN
admet-797	325	15	.	.	PROPN
admet-797	325	16	zalloum	zalloum	PROPN
admet-797	325	17	,	,	PUNCT
admet-797	325	18	f.	f.	PROPN
admet-797	325	19	ijbara	ijbara	PROPN
admet-797	325	20	,	,	PUNCT
admet-797	325	21	i.i	i.i	PROPN
admet-797	325	22	.	.	PROPN
admet-797	325	23	hamdan	hamdan	PROPN
admet-797	325	24	.	.	PUNCT
admet-797	326	1	the	the	DET
admet-797	326	2	effect	effect	NOUN
admet-797	326	3	of	of	ADP
admet-797	326	4	ferrous	ferrous	ADJ
admet-797	326	5	ions	ion	NOUN
admet-797	326	6	,	,	PUNCT
admet-797	326	7	calcium	calcium	NOUN
admet-797	326	8	ions	ion	NOUN
admet-797	326	9	and	and	CCONJ
admet-797	326	10	citric	citric	ADJ
admet-797	326	11	acid	acid	NOUN
admet-797	326	12	on	on	ADP
admet-797	326	13	absorption	absorption	NOUN
admet-797	326	14	of	of	ADP
admet-797	326	15	ciprofloxacin	ciprofloxacin	NOUN
admet-797	326	16	across	across	ADP
admet-797	326	17	caco-2	caco-2	NUM
admet-797	326	18	cells	cell	NOUN
admet-797	326	19	:	:	PUNCT
admet-797	326	20	practical	practical	ADJ
admet-797	326	21	and	and	CCONJ
admet-797	326	22	structural	structural	ADJ
admet-797	326	23	approach	approach	NOUN
admet-797	326	24	.	.	PUNCT
admet-797	327	1	drug	drug	PROPN
admet-797	327	2	dev	dev	PROPN
admet-797	327	3	.	.	PUNCT
admet-797	328	1	ind	ind	PROPN
admet-797	328	2	.	.	PUNCT
admet-797	329	1	pharm	pharm	PROPN
admet-797	329	2	.	.	PUNCT
admet-797	330	1	45	45	NUM
admet-797	330	2	(	(	PUNCT
admet-797	330	3	2019	2019	NUM
admet-797	330	4	)	)	PUNCT
admet-797	330	5	292–303	292–303	NUM
admet-797	330	6	.	.	PUNCT
admet-797	331	1	[	[	X
admet-797	331	2	26	26	NUM
admet-797	331	3	]	]	X
admet-797	331	4	m.	m.	NOUN
admet-797	331	5	kansy	kansy	PROPN
admet-797	331	6	,	,	PUNCT
admet-797	331	7	f.	f.	PROPN
admet-797	331	8	senner	senner	PROPN
admet-797	331	9	,	,	PUNCT
admet-797	331	10	k.	k.	PROPN
admet-797	331	11	gubernator	gubernator	PROPN
admet-797	331	12	.	.	PUNCT
admet-797	332	1	physicochemical	physicochemical	ADJ
admet-797	332	2	high	high	ADJ
admet-797	332	3	throughput	throughput	NOUN
admet-797	332	4	screening	screening	NOUN
admet-797	332	5	:	:	PUNCT
admet-797	332	6	parallel	parallel	ADJ
admet-797	332	7	artificial	artificial	ADJ
admet-797	332	8	membrane	membrane	NOUN
admet-797	332	9	permeation	permeation	NOUN
admet-797	332	10	assay	assay	VERB
admet-797	332	11	in	in	ADP
admet-797	332	12	the	the	DET
admet-797	332	13	description	description	NOUN
admet-797	332	14	of	of	ADP
admet-797	332	15	passive	passive	ADJ
admet-797	332	16	absorption	absorption	NOUN
admet-797	332	17	processes	process	NOUN
admet-797	332	18	.	.	PUNCT
admet-797	333	1	j.	j.	PROPN
admet-797	333	2	med	med	PROPN
admet-797	333	3	.	.	PROPN
admet-797	333	4	chem	chem	PROPN
admet-797	333	5	.	.	PUNCT
admet-797	334	1	41	41	NUM
admet-797	334	2	(	(	PUNCT
admet-797	334	3	1998	1998	NUM
admet-797	334	4	)	)	PUNCT
admet-797	334	5	1007–1010	1007–1010	NOUN
admet-797	334	6	.	.	PUNCT
admet-797	335	1	[	[	X
admet-797	335	2	27	27	NUM
admet-797	335	3	]	]	PUNCT
admet-797	335	4	k.	k.	PROPN
admet-797	335	5	sugano	sugano	PROPN
admet-797	335	6	,	,	PUNCT
admet-797	335	7	h.	h.	PROPN
admet-797	335	8	hamada	hamada	PROPN
admet-797	335	9	,	,	PUNCT
admet-797	335	10	m.	m.	PROPN
admet-797	335	11	machida	machida	PROPN
admet-797	335	12	,	,	PUNCT
admet-797	335	13	h.	h.	PROPN
admet-797	335	14	ushio	ushio	PROPN
admet-797	335	15	.	.	PUNCT
admet-797	336	1	high	high	ADJ
admet-797	336	2	throughput	throughput	NOUN
admet-797	336	3	prediction	prediction	NOUN
admet-797	336	4	of	of	ADP
admet-797	336	5	oral	oral	ADJ
admet-797	336	6	absorption	absorption	NOUN
admet-797	336	7	:	:	PUNCT
admet-797	336	8	improvement	improvement	NOUN
admet-797	336	9	of	of	ADP
admet-797	336	10	the	the	DET
admet-797	336	11	composition	composition	NOUN
admet-797	336	12	of	of	ADP
admet-797	336	13	the	the	DET
admet-797	336	14	lipid	lipid	NOUN
admet-797	336	15	solution	solution	NOUN
admet-797	336	16	used	use	VERB
admet-797	336	17	in	in	ADP
admet-797	336	18	parallel	parallel	ADJ
admet-797	336	19	artificial	artificial	ADJ
admet-797	336	20	membrane	membrane	NOUN
admet-797	336	21	permeation	permeation	NOUN
admet-797	336	22	assay	assay	NOUN
admet-797	336	23	.	.	PUNCT
admet-797	337	1	j.	j.	PROPN
admet-797	337	2	biomol	biomol	PROPN
admet-797	337	3	.	.	PUNCT
admet-797	338	1	screen	screen	NOUN
admet-797	338	2	.	.	PUNCT
admet-797	339	1	6	6	NUM
admet-797	339	2	(	(	PUNCT
admet-797	339	3	2001	2001	NUM
admet-797	339	4	)	)	PUNCT
admet-797	339	5	189	189	NUM
admet-797	339	6	-	-	SYM
admet-797	339	7	196	196	NUM
admet-797	339	8	.	.	PUNCT
admet-797	340	1	[	[	X
admet-797	340	2	28	28	NUM
admet-797	340	3	]	]	PUNCT
admet-797	340	4	k.	k.	PROPN
admet-797	340	5	sugano	sugano	PROPN
admet-797	340	6	,	,	PUNCT
admet-797	340	7	m.	m.	PROPN
admet-797	340	8	kansy	kansy	PROPN
admet-797	340	9	,	,	PUNCT
admet-797	340	10	p.	p.	PROPN
admet-797	340	11	artursson	artursson	PROPN
admet-797	340	12	,	,	PUNCT
admet-797	340	13	a.	a.	PROPN
admet-797	340	14	avdeef	avdeef	PROPN
admet-797	340	15	,	,	PUNCT
admet-797	340	16	s.	s.	PROPN
admet-797	340	17	bendels	bendels	PROPN
admet-797	340	18	,	,	PUNCT
admet-797	340	19	l.	l.	PROPN
admet-797	340	20	di	di	PROPN
admet-797	340	21	,	,	PUNCT
admet-797	340	22	g.f	g.f	PROPN
admet-797	340	23	.	.	PROPN
admet-797	340	24	ecker	ecker	PROPN
admet-797	340	25	,	,	PUNCT
admet-797	340	26	b.	b.	PROPN
admet-797	340	27	faller	faller	PROPN
admet-797	340	28	,	,	PUNCT
admet-797	340	29	h.	h.	PROPN
admet-797	340	30	fischer	fischer	PROPN
admet-797	340	31	,	,	PUNCT
admet-797	340	32	g.	g.	PROPN
admet-797	340	33	gerebtzoff	gerebtzoff	PROPN
admet-797	340	34	,	,	PUNCT
admet-797	340	35	h.	h.	PROPN
admet-797	340	36	lennernaes	lennernaes	PROPN
admet-797	340	37	,	,	PUNCT
admet-797	340	38	f.	f.	PROPN
admet-797	340	39	senner	senner	PROPN
admet-797	340	40	.	.	PUNCT
admet-797	341	1	coexistence	coexistence	NOUN
admet-797	341	2	of	of	ADP
admet-797	341	3	passive	passive	ADJ
admet-797	341	4	and	and	CCONJ
admet-797	341	5	carrier	carrier	NOUN
admet-797	341	6	-	-	PUNCT
admet-797	341	7	mediated	mediate	VERB
admet-797	341	8	processes	process	NOUN
admet-797	341	9	in	in	ADP
admet-797	341	10	drug	drug	NOUN
admet-797	341	11	transport	transport	NOUN
admet-797	341	12	.	.	PUNCT
admet-797	342	1	nat	nat	PROPN
admet-797	342	2	.	.	PUNCT
admet-797	343	1	rev	rev	PROPN
admet-797	343	2	.	.	PROPN
admet-797	343	3	drug	drug	NOUN
admet-797	343	4	discov	discov	NOUN
admet-797	343	5	.	.	PUNCT
admet-797	344	1	9	9	NUM
admet-797	344	2	(	(	PUNCT
admet-797	344	3	2010	2010	NUM
admet-797	344	4	)	)	PUNCT
admet-797	344	5	597	597	NUM
admet-797	344	6	-	-	SYM
admet-797	344	7	614	614	NUM
admet-797	344	8	.	.	PUNCT
admet-797	345	1	[	[	X
admet-797	345	2	29	29	NUM
admet-797	345	3	]	]	PUNCT
admet-797	345	4	a.	a.	NOUN
admet-797	345	5	avdeef	avdeef	PROPN
admet-797	345	6	,	,	PUNCT
admet-797	345	7	s.	s.	PROPN
admet-797	345	8	bendels	bendels	PROPN
admet-797	345	9	,	,	PUNCT
admet-797	345	10	l.	l.	PROPN
admet-797	345	11	di	di	PROPN
admet-797	345	12	,	,	PUNCT
admet-797	345	13	b.	b.	PROPN
admet-797	345	14	faller	faller	PROPN
admet-797	345	15	,	,	PUNCT
admet-797	345	16	m.	m.	PROPN
admet-797	345	17	kansy	kansy	PROPN
admet-797	345	18	,	,	PUNCT
admet-797	345	19	k.	k.	PROPN
admet-797	345	20	sugano	sugano	PROPN
admet-797	345	21	,	,	PUNCT
admet-797	345	22	y.	y.	PROPN
admet-797	345	23	yamauchi	yamauchi	PROPN
admet-797	345	24	.	.	PUNCT
admet-797	346	1	pampa	pampa	PROPN
admet-797	346	2	critical	critical	ADJ
admet-797	346	3	factors	factor	NOUN
admet-797	346	4	for	for	ADP
admet-797	346	5	better	well	ADJ
admet-797	346	6	predictions	prediction	NOUN
admet-797	346	7	of	of	ADP
admet-797	346	8	absorption	absorption	NOUN
admet-797	346	9	.	.	PUNCT
admet-797	347	1	j.	j.	PROPN
admet-797	347	2	pharm	pharm	PROPN
admet-797	347	3	.	.	PUNCT
admet-797	348	1	sci	sci	PROPN
admet-797	348	2	.	.	PROPN
admet-797	349	1	96	96	NUM
admet-797	349	2	(	(	PUNCT
admet-797	349	3	2007	2007	NUM
admet-797	349	4	)	)	PUNCT
admet-797	349	5	2893	2893	NUM
admet-797	349	6	-	-	SYM
admet-797	349	7	2909	2909	NUM
admet-797	349	8	.	.	PUNCT
admet-797	350	1	[	[	X
admet-797	350	2	30	30	NUM
admet-797	350	3	]	]	X
admet-797	350	4	s.	s.	PROPN
admet-797	350	5	yamauchi	yamauchi	PROPN
admet-797	350	6	,	,	PUNCT
admet-797	350	7	k.	k.	PROPN
admet-797	350	8	sugano	sugano	PROPN
admet-797	350	9	.	.	PUNCT
admet-797	350	10	permeation	permeation	NOUN
admet-797	350	11	characteristics	characteristic	NOUN
admet-797	350	12	of	of	ADP
admet-797	350	13	tetracyclines	tetracycline	NOUN
admet-797	350	14	in	in	ADP
admet-797	350	15	parallel	parallel	ADJ
admet-797	350	16	artificial	artificial	ADJ
admet-797	350	17	membrane	membrane	NOUN
admet-797	350	18	permeation	permeation	NOUN
admet-797	350	19	assay	assay	NOUN
admet-797	350	20	.	.	PUNCT
admet-797	351	1	admet	admet	PROPN
admet-797	351	2	dmpk	dmpk	PROPN
admet-797	351	3	7	7	NUM
admet-797	351	4	(	(	PUNCT
admet-797	351	5	2019	2019	NUM
admet-797	351	6	)	)	PUNCT
admet-797	351	7	151–160	151–160	NUM
admet-797	351	8	.	.	PUNCT
admet-797	352	1	[	[	X
admet-797	352	2	31	31	NUM
admet-797	352	3	]	]	PUNCT
admet-797	352	4	s.	s.	PROPN
admet-797	352	5	babić	babić	PROPN
admet-797	352	6	,	,	PUNCT
admet-797	352	7	a.j.m	a.j.m	NOUN
admet-797	352	8	.	.	PUNCT
admet-797	353	1	horvat	horvat	NOUN
admet-797	353	2	,	,	PUNCT
admet-797	353	3	d.	d.	PROPN
admet-797	353	4	mutavdžić	mutavdžić	PROPN
admet-797	353	5	pavlović	pavlović	VERB
admet-797	353	6	,	,	PUNCT
admet-797	353	7	m.	m.	NOUN
admet-797	353	8	kaštelan	kaštelan	PROPN
admet-797	353	9	-	-	PUNCT
admet-797	353	10	macan	macan	PROPN
admet-797	353	11	.	.	PUNCT
admet-797	354	1	determination	determination	NOUN
admet-797	354	2	of	of	ADP
admet-797	354	3	pka	pka	PROPN
admet-797	354	4	values	value	NOUN
admet-797	354	5	of	of	ADP
admet-797	354	6	active	active	ADJ
admet-797	354	7	pharmaceutical	pharmaceutical	ADJ
admet-797	354	8	ingredients	ingredient	NOUN
admet-797	354	9	.	.	PUNCT
admet-797	355	1	trac	trac	NOUN
admet-797	355	2	trends	trend	NOUN
admet-797	355	3	anal	anal	PROPN
admet-797	355	4	.	.	PUNCT
admet-797	356	1	chem	chem	PROPN
admet-797	356	2	.	.	PUNCT
admet-797	357	1	26	26	NUM
admet-797	357	2	(	(	PUNCT
admet-797	357	3	2007	2007	NUM
admet-797	357	4	)	)	PUNCT
admet-797	357	5	1043–1061	1043–1061	NOUN
admet-797	357	6	.	.	PUNCT
admet-797	358	1	[	[	X
admet-797	358	2	32	32	NUM
admet-797	358	3	]	]	PUNCT
admet-797	358	4	s.	s.	PROPN
admet-797	358	5	şanli	şanli	PROPN
admet-797	358	6	,	,	PUNCT
admet-797	358	7	n.	n.	NOUN
admet-797	358	8	şanli	şanli	PROPN
admet-797	358	9	,	,	PUNCT
admet-797	358	10	g.	g.	PROPN
admet-797	358	11	alsancak	alsancak	PROPN
admet-797	358	12	.	.	PUNCT
admet-797	359	1	determination	determination	NOUN
admet-797	359	2	of	of	ADP
admet-797	359	3	protonation	protonation	NOUN
admet-797	359	4	constants	constant	NOUN
admet-797	359	5	of	of	ADP
admet-797	359	6	some	some	DET
admet-797	359	7	tetracycline	tetracycline	ADJ
admet-797	359	8	antibiotics	antibiotic	NOUN
admet-797	359	9	by	by	ADP
admet-797	359	10	potentiometry	potentiometry	NOUN
admet-797	359	11	and	and	CCONJ
admet-797	359	12	lc	lc	NOUN
admet-797	359	13	methods	method	NOUN
admet-797	359	14	in	in	ADP
admet-797	359	15	water	water	NOUN
admet-797	359	16	and	and	CCONJ
admet-797	359	17	acetonitrile	acetonitrile	ADJ
admet-797	359	18	-	-	PUNCT
admet-797	359	19	water	water	NOUN
admet-797	359	20	binary	binary	ADJ
admet-797	359	21	mixtures	mixture	NOUN
admet-797	359	22	.	.	PUNCT
admet-797	360	1	j.	j.	PROPN
admet-797	360	2	braz	braz	PROPN
admet-797	360	3	.	.	PUNCT
admet-797	360	4	chem	chem	PROPN
admet-797	360	5	.	.	PUNCT
admet-797	361	1	soc	soc	PROPN
admet-797	361	2	.	.	PUNCT
admet-797	362	1	20	20	NUM
admet-797	362	2	(	(	PUNCT
admet-797	362	3	2009	2009	NUM
admet-797	362	4	)	)	PUNCT
admet-797	362	5	939–946	939–946	NUM
admet-797	362	6	.	.	PUNCT
admet-797	363	1	[	[	X
admet-797	363	2	33	33	NUM
admet-797	363	3	]	]	X
admet-797	363	4	pmda	pmda	VERB
admet-797	363	5	.	.	PUNCT
admet-797	363	6	minocycline	minocycline	PROPN
admet-797	363	7	hydrochloride	hydrochloride	NOUN
admet-797	363	8	drug	drug	NOUN
admet-797	363	9	product	product	NOUN
admet-797	363	10	information	information	NOUN
admet-797	363	11	.	.	PUNCT
admet-797	364	1	(	(	PUNCT
admet-797	364	2	2011	2011	NUM
admet-797	364	3	)	)	PUNCT
admet-797	364	4	.	.	PUNCT
admet-797	365	1	https://www.info.pmda.go.jp/igo/pack/6152005f1052_2_11/.	https://www.info.pmda.go.jp/igo/pack/6152005f1052_2_11/.	PROPN
admet-797	366	1	[	[	X
admet-797	366	2	34	34	NUM
admet-797	366	3	]	]	PUNCT
admet-797	366	4	a.	a.	NOUN
admet-797	366	5	avdeef	avdeef	PROPN
admet-797	366	6	.	.	PUNCT
admet-797	367	1	absorption	absorption	NOUN
admet-797	367	2	and	and	CCONJ
admet-797	367	3	drug	drug	NOUN
admet-797	367	4	development	development	NOUN
admet-797	367	5	:	:	PUNCT
admet-797	367	6	solubility	solubility	NOUN
admet-797	367	7	,	,	PUNCT
admet-797	367	8	permeability	permeability	NOUN
admet-797	367	9	,	,	PUNCT
admet-797	367	10	and	and	CCONJ
admet-797	367	11	charge	charge	NOUN
admet-797	367	12	state	state	NOUN
admet-797	367	13	,	,	PUNCT
admet-797	367	14	second	second	ADJ
admet-797	367	15	edition	edition	NOUN
admet-797	367	16	,	,	PUNCT
admet-797	367	17	john	john	PROPN
admet-797	367	18	wiley	wiley	PROPN
admet-797	367	19	&	&	CCONJ
admet-797	367	20	sons	sons	PROPN
admet-797	367	21	,	,	PUNCT
admet-797	367	22	inc	inc	PROPN
admet-797	367	23	.	.	PROPN
admet-797	367	24	,	,	PUNCT
admet-797	367	25	2012	2012	NUM
admet-797	367	26	.	.	PUNCT
admet-797	368	1	[	[	X
admet-797	368	2	35	35	NUM
admet-797	368	3	]	]	X
admet-797	368	4	b.	b.	PROPN
admet-797	368	5	faller	faller	PROPN
admet-797	368	6	,	,	PUNCT
admet-797	368	7	h.p	h.p	PROPN
admet-797	368	8	.	.	PROPN
admet-797	368	9	grimm	grimm	PROPN
admet-797	368	10	,	,	PUNCT
admet-797	368	11	f.	f.	PROPN
admet-797	368	12	loeuillet	loeuillet	PROPN
admet-797	368	13	-	-	PUNCT
admet-797	368	14	ritzler	ritzler	NOUN
admet-797	368	15	,	,	PUNCT
admet-797	368	16	s.	s.	PROPN
admet-797	368	17	arnold	arnold	PROPN
admet-797	368	18	,	,	PUNCT
admet-797	368	19	x.	x.	PROPN
admet-797	368	20	briand	briand	PROPN
admet-797	368	21	.	.	PUNCT
admet-797	369	1	high	high	ADJ
admet-797	369	2	-	-	PUNCT
admet-797	369	3	throughput	throughput	NOUN
admet-797	369	4	lipophilicity	lipophilicity	NOUN
admet-797	369	5	measurement	measurement	NOUN
admet-797	369	6	with	with	ADP
admet-797	369	7	immobilized	immobilized	ADJ
admet-797	369	8	artificial	artificial	ADJ
admet-797	369	9	membranes	membrane	NOUN
admet-797	369	10	.	.	PUNCT
admet-797	370	1	j.	j.	PROPN
admet-797	370	2	med	med	PROPN
admet-797	370	3	.	.	PROPN
admet-797	370	4	chem	chem	PROPN
admet-797	370	5	.	.	PUNCT
admet-797	371	1	48	48	NUM
admet-797	371	2	(	(	PUNCT
admet-797	371	3	2005	2005	NUM
admet-797	371	4	)	)	PUNCT
admet-797	371	5	2571–2576	2571–2576	NUM
admet-797	371	6	.	.	PUNCT
admet-797	372	1	[	[	X
admet-797	372	2	36	36	NUM
admet-797	372	3	]	]	PUNCT
admet-797	372	4	z.	z.	PROPN
admet-797	372	5	song	song	PROPN
admet-797	372	6	,	,	PUNCT
admet-797	372	7	k.	k.	PROPN
admet-797	372	8	terada	terada	PROPN
admet-797	372	9	,	,	PUNCT
admet-797	372	10	k.	k.	PROPN
admet-797	372	11	sugano	sugano	PROPN
admet-797	372	12	.	.	PUNCT
admet-797	372	13	reversed	reverse	VERB
admet-797	372	14	phase	phase	NOUN
admet-797	372	15	parallel	parallel	ADJ
admet-797	372	16	artificial	artificial	ADJ
admet-797	372	17	membrane	membrane	NOUN
admet-797	372	18	permeation	permeation	NOUN
admet-797	372	19	assay	assay	VERB
admet-797	372	20	for	for	ADP
admet-797	372	21	log	log	NOUN
admet-797	372	22	p	p	PROPN
admet-797	372	23	measurement	measurement	NOUN
admet-797	372	24	.	.	PUNCT
admet-797	373	1	admet	admet	PROPN
admet-797	373	2	dmpk	dmpk	PROPN
admet-797	373	3	4	4	NUM
admet-797	373	4	(	(	PUNCT
admet-797	373	5	2016	2016	NUM
admet-797	373	6	)	)	PUNCT
admet-797	373	7	54	54	NUM
admet-797	373	8	-	-	SYM
admet-797	373	9	59	59	NUM
admet-797	373	10	.	.	PUNCT
admet-797	374	1	http://dx.doi.org/10.5599/admet.797	http://dx.doi.org/10.5599/admet.797	PROPN
admet-797	374	2	kiyohiko	kiyohiko	PROPN
admet-797	374	3	sugano	sugano	PROPN
admet-797	374	4	et	et	PROPN
admet-797	374	5	al	al	PROPN
admet-797	374	6	.	.	PROPN
admet-797	374	7	admet	admet	PROPN
admet-797	374	8	&	&	CCONJ
admet-797	374	9	dmpk	dmpk	PROPN
admet-797	374	10	8(2	8(2	NUM
admet-797	374	11	)	)	PUNCT
admet-797	374	12	(	(	PUNCT
admet-797	374	13	2020	2020	NUM
admet-797	374	14	)	)	PUNCT
admet-797	374	15	129	129	NUM
admet-797	374	16	-	-	SYM
admet-797	374	17	138	138	NUM
admet-797	374	18	138	138	NUM
admet-797	374	19	[	[	X
admet-797	374	20	37	37	NUM
admet-797	374	21	]	]	PUNCT
admet-797	374	22	mhlw	mhlw	NOUN
admet-797	374	23	.	.	PUNCT
admet-797	375	1	overview	overview	NOUN
admet-797	375	2	of	of	ADP
admet-797	375	3	dietary	dietary	ADJ
admet-797	375	4	reference	reference	NOUN
admet-797	375	5	intakes	intake	NOUN
admet-797	375	6	for	for	ADP
admet-797	375	7	japanese	japanese	ADJ
admet-797	375	8	(	(	PUNCT
admet-797	375	9	2015	2015	NUM
admet-797	375	10	)	)	PUNCT
admet-797	375	11	,	,	PUNCT
admet-797	375	12	2015	2015	NUM
admet-797	375	13	.	.	PUNCT
admet-797	376	1	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	NOUN
admet-797	376	2	.	.	PUNCT
admet-797	377	1	[	[	X
admet-797	377	2	38	38	NUM
admet-797	377	3	]	]	PUNCT
admet-797	377	4	c.	c.	PROPN
admet-797	377	5	schiller	schiller	PROPN
admet-797	377	6	,	,	PUNCT
admet-797	377	7	c.p	c.p	PROPN
admet-797	377	8	.	.	PROPN
admet-797	377	9	fröhlich	fröhlich	PROPN
admet-797	377	10	,	,	PUNCT
admet-797	377	11	t.	t.	PROPN
admet-797	377	12	giessmann	giessmann	PROPN
admet-797	377	13	,	,	PUNCT
admet-797	377	14	w.	w.	PROPN
admet-797	377	15	siegmund	siegmund	PROPN
admet-797	377	16	,	,	PUNCT
admet-797	377	17	h.	h.	PROPN
admet-797	377	18	mönnikes	mönnikes	PROPN
admet-797	377	19	,	,	PUNCT
admet-797	377	20	n.	n.	NOUN
admet-797	377	21	hosten	hosten	PROPN
admet-797	377	22	,	,	PUNCT
admet-797	377	23	w.	w.	PROPN
admet-797	377	24	weitschies	weitschie	NOUN
admet-797	377	25	.	.	PUNCT
admet-797	378	1	intestinal	intestinal	ADJ
admet-797	378	2	fluid	fluid	ADJ
admet-797	378	3	volumes	volume	NOUN
admet-797	378	4	and	and	CCONJ
admet-797	378	5	transit	transit	NOUN
admet-797	378	6	of	of	ADP
admet-797	378	7	dosage	dosage	NOUN
admet-797	378	8	forms	form	NOUN
admet-797	378	9	as	as	SCONJ
admet-797	378	10	assessed	assess	VERB
admet-797	378	11	by	by	ADP
admet-797	378	12	magnetic	magnetic	ADJ
admet-797	378	13	resonance	resonance	NOUN
admet-797	378	14	imaging	imaging	NOUN
admet-797	378	15	.	.	PUNCT
admet-797	379	1	aliment	aliment	NOUN
admet-797	379	2	.	.	PUNCT
admet-797	380	1	pharmacol	pharmacol	PROPN
admet-797	380	2	.	.	PUNCT
admet-797	381	1	ther	ther	PROPN
admet-797	381	2	.	.	PUNCT
admet-797	382	1	22	22	NUM
admet-797	382	2	(	(	PUNCT
admet-797	382	3	2005	2005	NUM
admet-797	382	4	)	)	PUNCT
admet-797	383	1	971–979	971–979	NUM
admet-797	383	2	.	.	PUNCT
admet-797	384	1	[	[	X
admet-797	384	2	39	39	NUM
admet-797	384	3	]	]	X
admet-797	384	4	j.j	j.j	PROPN
admet-797	384	5	.	.	PROPN
admet-797	384	6	werner	werner	PROPN
admet-797	384	7	,	,	PUNCT
admet-797	384	8	w.a	w.a	PROPN
admet-797	384	9	.	.	PROPN
admet-797	384	10	arnold	arnold	PROPN
admet-797	384	11	,	,	PUNCT
admet-797	384	12	k.	k.	PROPN
admet-797	384	13	mcneill	mcneill	PROPN
admet-797	384	14	.	.	PUNCT
admet-797	385	1	water	water	NOUN
admet-797	385	2	hardness	hardness	ADV
admet-797	385	3	as	as	ADP
admet-797	385	4	a	a	DET
admet-797	385	5	photochemical	photochemical	ADJ
admet-797	385	6	parameter	parameter	NOUN
admet-797	385	7	:	:	PUNCT
admet-797	385	8	tetracycline	tetracycline	NOUN
admet-797	385	9	photolysis	photolysis	NOUN
admet-797	385	10	as	as	ADP
admet-797	385	11	a	a	DET
admet-797	385	12	function	function	NOUN
admet-797	385	13	of	of	ADP
admet-797	385	14	calcium	calcium	NOUN
admet-797	385	15	concentration	concentration	NOUN
admet-797	385	16	,	,	PUNCT
admet-797	385	17	magnesium	magnesium	NOUN
admet-797	385	18	concentration	concentration	NOUN
admet-797	385	19	,	,	PUNCT
admet-797	385	20	and	and	CCONJ
admet-797	385	21	ph	ph	PROPN
admet-797	385	22	.	.	PROPN
admet-797	385	23	environ	environ	PROPN
admet-797	385	24	.	.	PUNCT
admet-797	386	1	sci	sci	PROPN
admet-797	386	2	.	.	PROPN
admet-797	386	3	technol	technol	PROPN
admet-797	386	4	.	.	PROPN
admet-797	387	1	40	40	NUM
admet-797	387	2	(	(	PUNCT
admet-797	387	3	2006	2006	NUM
admet-797	387	4	)	)	PUNCT
admet-797	388	1	7236–7241	7236–7241	NUM
admet-797	388	2	.	.	PUNCT
admet-797	389	1	[	[	X
admet-797	389	2	40	40	NUM
admet-797	389	3	]	]	PUNCT
admet-797	389	4	l.	l.	PROPN
admet-797	389	5	jin	jin	PROPN
admet-797	389	6	,	,	PUNCT
admet-797	389	7	x.	x.	PROPN
admet-797	389	8	amaya	amaya	PROPN
admet-797	389	9	-	-	PUNCT
admet-797	389	10	mazo	mazo	PROPN
admet-797	389	11	,	,	PUNCT
admet-797	389	12	m.e	m.e	PROPN
admet-797	389	13	.	.	PROPN
admet-797	389	14	apel	apel	PROPN
admet-797	389	15	,	,	PUNCT
admet-797	389	16	s.s	s.s	PROPN
admet-797	389	17	.	.	PROPN
admet-797	389	18	sankisa	sankisa	PROPN
admet-797	389	19	,	,	PUNCT
admet-797	389	20	e.	e.	PROPN
admet-797	389	21	johnson	johnson	PROPN
admet-797	389	22	,	,	PUNCT
admet-797	389	23	m.a	m.a	PROPN
admet-797	389	24	.	.	PROPN
admet-797	389	25	zbyszynska	zbyszynska	PROPN
admet-797	389	26	,	,	PUNCT
admet-797	389	27	a.	a.	PROPN
admet-797	389	28	han	han	PROPN
admet-797	389	29	.	.	PUNCT
admet-797	390	1	ca2	ca2	PROPN
admet-797	390	2	+	+	PROPN
admet-797	390	3	and	and	CCONJ
admet-797	390	4	mg2	mg2	PROPN
admet-797	390	5	+	+	CCONJ
admet-797	390	6	bind	bind	VERB
admet-797	390	7	tetracycline	tetracycline	NOUN
admet-797	390	8	with	with	ADP
admet-797	390	9	distinct	distinct	ADJ
admet-797	390	10	stoichiometries	stoichiometry	NOUN
admet-797	390	11	and	and	CCONJ
admet-797	390	12	linked	link	VERB
admet-797	390	13	deprotonation	deprotonation	NOUN
admet-797	390	14	.	.	PUNCT
admet-797	391	1	biophys	biophy	NOUN
admet-797	391	2	.	.	PUNCT
admet-797	392	1	chem	chem	NOUN
admet-797	392	2	.	.	PUNCT
admet-797	393	1	128	128	NUM
admet-797	393	2	(	(	PUNCT
admet-797	393	3	2007	2007	NUM
admet-797	393	4	)	)	PUNCT
admet-797	393	5	185–196	185–196	NUM
admet-797	393	6	.	.	PUNCT
admet-797	394	1	[	[	X
admet-797	394	2	41	41	NUM
admet-797	394	3	]	]	X
admet-797	394	4	d.c	d.c	PROPN
admet-797	394	5	.	.	PROPN
admet-797	394	6	maxwell	maxwell	PROPN
admet-797	394	7	,	,	PUNCT
admet-797	394	8	p.j.a	p.j.a	PROPN
admet-797	394	9	.	.	PUNCT
admet-797	394	10	smith	smith	PROPN
admet-797	394	11	,	,	PUNCT
admet-797	394	12	s.p	s.p	PROPN
admet-797	394	13	.	.	PROPN
admet-797	394	14	wilford	wilford	PROPN
admet-797	394	15	.	.	PUNCT
admet-797	395	1	stabilities	stability	NOUN
admet-797	395	2	of	of	ADP
admet-797	395	3	some	some	DET
admet-797	395	4	alkaline	alkaline	NOUN
admet-797	395	5	earth	earth	NOUN
admet-797	395	6	chelates	chelate	NOUN
admet-797	395	7	of	of	ADP
admet-797	395	8	tetracycline	tetracycline	NOUN
admet-797	395	9	.	.	PUNCT
admet-797	396	1	nature	nature	NOUN
admet-797	396	2	198	198	NUM
admet-797	396	3	(	(	PUNCT
admet-797	396	4	1963	1963	NUM
admet-797	396	5	)	)	PUNCT
admet-797	396	6	577–578	577–578	NUM
admet-797	396	7	.	.	PUNCT
admet-797	397	1	[	[	X
admet-797	397	2	42	42	NUM
admet-797	397	3	]	]	X
admet-797	397	4	l.z	l.z	PROPN
admet-797	397	5	.	.	PROPN
admet-797	397	6	benet	benet	PROPN
admet-797	397	7	,	,	PUNCT
admet-797	397	8	j.e	j.e	PROPN
admet-797	397	9	.	.	PROPN
admet-797	397	10	goyan	goyan	PROPN
admet-797	397	11	.	.	PUNCT
admet-797	398	1	thermodynamics	thermodynamic	NOUN
admet-797	398	2	of	of	ADP
admet-797	398	3	chelation	chelation	NOUN
admet-797	398	4	by	by	ADP
admet-797	398	5	tetracyclines	tetracyclines	PROPN
admet-797	398	6	.	.	PUNCT
admet-797	399	1	j.	j.	PROPN
admet-797	399	2	pharm	pharm	PROPN
admet-797	399	3	.	.	PUNCT
admet-797	400	1	sci	sci	PROPN
admet-797	400	2	.	.	PROPN
admet-797	401	1	55	55	NUM
admet-797	401	2	(	(	PUNCT
admet-797	401	3	1966	1966	NUM
admet-797	401	4	)	)	PUNCT
admet-797	401	5	1184	1184	NUM
admet-797	401	6	–	–	PUNCT
admet-797	401	7	1190	1190	NUM
admet-797	401	8	.	.	PUNCT
admet-797	402	1	[	[	X
admet-797	402	2	43	43	NUM
admet-797	402	3	]	]	X
admet-797	402	4	m.	m.	NOUN
admet-797	402	5	novák	novák	PROPN
admet-797	402	6	-	-	PUNCT
admet-797	402	7	pékli	pékli	NOUN
admet-797	402	8	,	,	PUNCT
admet-797	402	9	m.e.-h	m.e.-h	PROPN
admet-797	402	10	.	.	PROPN
admet-797	402	11	mesbah	mesbah	PROPN
admet-797	402	12	,	,	PUNCT
admet-797	402	13	g.	g.	PROPN
admet-797	402	14	pethö	pethö	PROPN
admet-797	402	15	.	.	PUNCT
admet-797	403	1	equilibrium	equilibrium	NOUN
admet-797	403	2	studies	study	NOUN
admet-797	403	3	on	on	ADP
admet-797	403	4	tetracycline	tetracycline	NOUN
admet-797	403	5	—	—	PUNCT
admet-797	403	6	metal	metal	NOUN
admet-797	403	7	ion	ion	NOUN
admet-797	403	8	systems	system	NOUN
admet-797	403	9	.	.	PUNCT
admet-797	404	1	j.	j.	PROPN
admet-797	404	2	pharm	pharm	PROPN
admet-797	404	3	.	.	PUNCT
admet-797	404	4	biomed	biome	VERB
admet-797	404	5	.	.	PUNCT
admet-797	405	1	anal	anal	ADJ
admet-797	405	2	.	.	PUNCT
admet-797	406	1	14	14	NUM
admet-797	406	2	(	(	PUNCT
admet-797	406	3	1996	1996	NUM
admet-797	406	4	)	)	PUNCT
admet-797	407	1	1025–1029	1025–1029	NUM
admet-797	407	2	.	.	PUNCT
admet-797	408	1	[	[	X
admet-797	408	2	44	44	NUM
admet-797	408	3	]	]	X
admet-797	408	4	h.a	h.a	PROPN
admet-797	408	5	.	.	PROPN
admet-797	408	6	duarte	duarte	PROPN
admet-797	408	7	,	,	PUNCT
admet-797	408	8	s.	s.	PROPN
admet-797	408	9	carvalho	carvalho	PROPN
admet-797	408	10	,	,	PUNCT
admet-797	408	11	e.b	e.b	PROPN
admet-797	408	12	.	.	PROPN
admet-797	408	13	paniago	paniago	PROPN
admet-797	408	14	,	,	PUNCT
admet-797	408	15	a.m.	a.m.	PROPN
admet-797	408	16	simas	simas	PROPN
admet-797	408	17	.	.	PUNCT
admet-797	409	1	importance	importance	NOUN
admet-797	409	2	of	of	ADP
admet-797	409	3	tautomers	tautomer	NOUN
admet-797	409	4	in	in	ADP
admet-797	409	5	the	the	DET
admet-797	409	6	chemical	chemical	ADJ
admet-797	409	7	behavior	behavior	NOUN
admet-797	409	8	of	of	ADP
admet-797	409	9	tetracyclines	tetracyclines	PROPN
admet-797	409	10	.	.	PUNCT
admet-797	410	1	j.	j.	PROPN
admet-797	410	2	pharm	pharm	PROPN
admet-797	410	3	.	.	PUNCT
admet-797	411	1	sci	sci	PROPN
admet-797	411	2	.	.	PROPN
admet-797	412	1	88	88	NUM
admet-797	412	2	(	(	PUNCT
admet-797	412	3	1999	1999	NUM
admet-797	412	4	)	)	PUNCT
admet-797	413	1	111–120	111–120	NUM
admet-797	413	2	.	.	PUNCT
admet-797	414	1	[	[	X
admet-797	414	2	45	45	NUM
admet-797	414	3	]	]	PUNCT
admet-797	414	4	a.	a.	NOUN
admet-797	414	5	pagliara	pagliara	PROPN
admet-797	414	6	,	,	PUNCT
admet-797	414	7	p.a	p.a	PROPN
admet-797	414	8	.	.	PROPN
admet-797	414	9	carrupt	carrupt	PROPN
admet-797	414	10	,	,	PUNCT
admet-797	414	11	g.	g.	PROPN
admet-797	414	12	caron	caron	PROPN
admet-797	414	13	,	,	PUNCT
admet-797	414	14	p.	p.	PROPN
admet-797	414	15	gaillard	gaillard	PROPN
admet-797	414	16	,	,	PUNCT
admet-797	414	17	b.	b.	PROPN
admet-797	414	18	testa	testa	PROPN
admet-797	414	19	.	.	PUNCT
admet-797	415	1	lipophilicity	lipophilicity	NOUN
admet-797	415	2	profiles	profile	NOUN
admet-797	415	3	of	of	ADP
admet-797	415	4	ampholytes	ampholyte	NOUN
admet-797	415	5	.	.	PUNCT
admet-797	416	1	chem	chem	PROPN
admet-797	416	2	.	.	PUNCT
admet-797	417	1	rev	rev	PROPN
admet-797	417	2	.	.	PROPN
admet-797	417	3	97	97	NUM
admet-797	417	4	(	(	PUNCT
admet-797	417	5	1997	1997	NUM
admet-797	417	6	)	)	PUNCT
admet-797	417	7	3385–3400	3385–3400	NUM
admet-797	417	8	.	.	PUNCT
admet-797	418	1	[	[	X
admet-797	418	2	46	46	NUM
admet-797	418	3	]	]	X
admet-797	418	4	h.	h.	PROPN
admet-797	418	5	terada	terada	PROPN
admet-797	418	6	,	,	PUNCT
admet-797	418	7	t.	t.	PROPN
admet-797	418	8	inagi	inagi	PROPN
admet-797	418	9	.	.	PUNCT
admet-797	419	1	proposed	propose	VERB
admet-797	419	2	partition	partition	NOUN
admet-797	419	3	mechanism	mechanism	NOUN
admet-797	419	4	of	of	ADP
admet-797	419	5	tetracycline	tetracycline	NOUN
admet-797	419	6	.	.	PUNCT
admet-797	420	1	chem	chem	NOUN
admet-797	420	2	.	.	PUNCT
admet-797	421	1	pharm	pharm	NOUN
admet-797	421	2	.	.	PUNCT
admet-797	422	1	bull	bull	NOUN
admet-797	422	2	.	.	PUNCT
admet-797	423	1	23	23	NUM
admet-797	423	2	(	(	PUNCT
admet-797	423	3	1975	1975	NUM
admet-797	423	4	)	)	PUNCT
admet-797	423	5	1960–1968	1960–1968	NUM
admet-797	423	6	.	.	PUNCT
admet-797	424	1	[	[	X
admet-797	424	2	47	47	NUM
admet-797	424	3	]	]	X
admet-797	424	4	s.r	s.r	PROPN
admet-797	424	5	.	.	PROPN
admet-797	424	6	martin	martin	PROPN
admet-797	424	7	.	.	PUNCT
admet-797	425	1	equilibrium	equilibrium	NOUN
admet-797	425	2	and	and	CCONJ
admet-797	425	3	kinetic	kinetic	ADJ
admet-797	425	4	studies	study	NOUN
admet-797	425	5	on	on	ADP
admet-797	425	6	the	the	DET
admet-797	425	7	interaction	interaction	NOUN
admet-797	425	8	of	of	ADP
admet-797	425	9	tetracyclines	tetracycline	NOUN
admet-797	425	10	with	with	ADP
admet-797	425	11	calcium	calcium	NOUN
admet-797	425	12	and	and	CCONJ
admet-797	425	13	magnesium	magnesium	NOUN
admet-797	425	14	.	.	PUNCT
admet-797	426	1	biophys	biophy	NOUN
admet-797	426	2	.	.	PUNCT
admet-797	427	1	chem	chem	NOUN
admet-797	427	2	.	.	PUNCT
admet-797	428	1	10	10	NUM
admet-797	428	2	(	(	PUNCT
admet-797	428	3	1979	1979	NUM
admet-797	428	4	)	)	PUNCT
admet-797	429	1	319–326	319–326	NUM
admet-797	429	2	.	.	PUNCT
admet-797	430	1	[	[	X
admet-797	430	2	48	48	NUM
admet-797	430	3	]	]	X
admet-797	430	4	n.p	n.p	PROPN
admet-797	430	5	.	.	PROPN
admet-797	430	6	franks	frank	NOUN
admet-797	430	7	,	,	PUNCT
admet-797	430	8	m.h	m.h	PROPN
admet-797	430	9	.	.	PROPN
admet-797	430	10	abraham	abraham	PROPN
admet-797	430	11	,	,	PUNCT
admet-797	430	12	w.r	w.r	PROPN
admet-797	430	13	.	.	PUNCT
admet-797	430	14	lieb	lieb	PROPN
admet-797	430	15	.	.	PUNCT
admet-797	431	1	molecular	molecular	ADJ
admet-797	431	2	organization	organization	NOUN
admet-797	431	3	of	of	ADP
admet-797	431	4	liquid	liquid	ADJ
admet-797	431	5	n	n	CCONJ
admet-797	431	6	-	-	PUNCT
admet-797	431	7	octanol	octanol	NOUN
admet-797	431	8	:	:	PUNCT
admet-797	431	9	an	an	DET
admet-797	431	10	x	x	ADJ
admet-797	431	11	-	-	NOUN
admet-797	431	12	ray	ray	NOUN
admet-797	431	13	diffraction	diffraction	NOUN
admet-797	431	14	analysis	analysis	NOUN
admet-797	431	15	.	.	PUNCT
admet-797	432	1	j.	j.	PROPN
admet-797	432	2	pharm	pharm	PROPN
admet-797	432	3	.	.	PUNCT
admet-797	433	1	sci	sci	PROPN
admet-797	433	2	.	.	PROPN
admet-797	434	1	82	82	NUM
admet-797	434	2	(	(	PUNCT
admet-797	434	3	1993	1993	NUM
admet-797	434	4	)	)	PUNCT
admet-797	435	1	466–470	466–470	NUM
admet-797	435	2	.	.	PUNCT
admet-797	436	1	[	[	X
admet-797	436	2	49	49	NUM
admet-797	436	3	]	]	PUNCT
admet-797	436	4	m.	m.	NOUN
admet-797	436	5	barza	barza	NOUN
admet-797	436	6	,	,	PUNCT
admet-797	436	7	r.b	r.b	PROPN
admet-797	436	8	.	.	PROPN
admet-797	436	9	brown	brown	PROPN
admet-797	436	10	,	,	PUNCT
admet-797	436	11	c.	c.	PROPN
admet-797	436	12	shanks	shank	NOUN
admet-797	436	13	,	,	PUNCT
admet-797	436	14	c.	c.	NOUN
admet-797	436	15	gamble	gamble	NOUN
admet-797	436	16	,	,	PUNCT
admet-797	436	17	l.	l.	PROPN
admet-797	436	18	weinstein	weinstein	PROPN
admet-797	436	19	.	.	PUNCT
admet-797	437	1	relation	relation	NOUN
admet-797	437	2	between	between	ADP
admet-797	437	3	lipophilicity	lipophilicity	NOUN
admet-797	437	4	and	and	CCONJ
admet-797	437	5	pharmacological	pharmacological	ADJ
admet-797	437	6	behavior	behavior	NOUN
admet-797	437	7	of	of	ADP
admet-797	437	8	minocycline	minocycline	PROPN
admet-797	437	9	,	,	PUNCT
admet-797	437	10	doxycycline	doxycycline	NOUN
admet-797	437	11	,	,	PUNCT
admet-797	437	12	tetracycline	tetracycline	NOUN
admet-797	437	13	,	,	PUNCT
admet-797	437	14	and	and	CCONJ
admet-797	437	15	oxytetracycline	oxytetracycline	VERB
admet-797	437	16	in	in	ADP
admet-797	437	17	dogs	dog	NOUN
admet-797	437	18	.	.	PUNCT
admet-797	438	1	antimicrob	antimicrob	PROPN
admet-797	438	2	.	.	PUNCT
admet-797	439	1	agents	agent	NOUN
admet-797	439	2	chemother	chemother	PROPN
admet-797	439	3	.	.	PUNCT
admet-797	440	1	8	8	NUM
admet-797	440	2	(	(	PUNCT
admet-797	440	3	1975	1975	NUM
admet-797	440	4	)	)	PUNCT
admet-797	441	1	713–720	713–720	NUM
admet-797	441	2	.	.	PUNCT
admet-797	442	1	[	[	X
admet-797	442	2	50	50	NUM
admet-797	442	3	]	]	X
admet-797	442	4	y.	y.	PROPN
admet-797	442	5	zhang	zhang	PROPN
admet-797	442	6	,	,	PUNCT
admet-797	442	7	s.a	s.a	PROPN
admet-797	442	8	.	.	PROPN
admet-797	442	9	boyd	boyd	PROPN
admet-797	442	10	,	,	PUNCT
admet-797	442	11	b.j	b.j	PROPN
admet-797	442	12	.	.	PROPN
admet-797	442	13	teppen	teppen	PROPN
admet-797	442	14	,	,	PUNCT
admet-797	442	15	j.m	j.m	PROPN
admet-797	442	16	.	.	PROPN
admet-797	442	17	tiedje	tiedje	PROPN
admet-797	442	18	,	,	PUNCT
admet-797	442	19	h.	h.	PROPN
admet-797	442	20	li	li	PROPN
admet-797	442	21	.	.	PROPN
admet-797	442	22	role	role	NOUN
admet-797	442	23	of	of	ADP
admet-797	442	24	tetracycline	tetracycline	ADJ
admet-797	442	25	speciation	speciation	NOUN
admet-797	442	26	in	in	ADP
admet-797	442	27	the	the	DET
admet-797	442	28	bioavailability	bioavailability	NOUN
admet-797	442	29	to	to	PART
admet-797	442	30	escherichia	escherichia	VERB
admet-797	442	31	coli	coli	NOUN
admet-797	442	32	for	for	ADP
admet-797	442	33	uptake	uptake	NOUN
admet-797	442	34	and	and	CCONJ
admet-797	442	35	expression	expression	NOUN
admet-797	442	36	of	of	ADP
admet-797	442	37	antibiotic	antibiotic	ADJ
admet-797	442	38	resistance	resistance	NOUN
admet-797	442	39	.	.	PUNCT
admet-797	443	1	environ	environ	PROPN
admet-797	443	2	.	.	PUNCT
admet-797	444	1	sci	sci	PROPN
admet-797	444	2	.	.	PROPN
admet-797	444	3	technol	technol	PROPN
admet-797	444	4	.	.	PUNCT
admet-797	445	1	48	48	NUM
admet-797	445	2	(	(	PUNCT
admet-797	445	3	2014	2014	NUM
admet-797	445	4	)	)	PUNCT
admet-797	445	5	4893–4900	4893–4900	NOUN
admet-797	445	6	.	.	PUNCT
admet-797	446	1	©	©	PROPN
admet-797	446	2	2020	2020	NUM
admet-797	446	3	by	by	ADP
admet-797	446	4	the	the	DET
admet-797	446	5	authors	author	NOUN
admet-797	446	6	;	;	PUNCT
admet-797	446	7	licensee	licensee	PROPN
admet-797	446	8	iapc	iapc	PROPN
admet-797	446	9	,	,	PUNCT
admet-797	446	10	zagreb	zagreb	PROPN
admet-797	446	11	,	,	PUNCT
admet-797	446	12	croatia	croatia	PROPN
admet-797	446	13	.	.	PUNCT
admet-797	447	1	this	this	DET
admet-797	447	2	article	article	NOUN
admet-797	447	3	is	be	AUX
admet-797	447	4	an	an	DET
admet-797	447	5	open	open	ADJ
admet-797	447	6	-	-	PUNCT
admet-797	447	7	access	access	NOUN
admet-797	447	8	article	article	NOUN
admet-797	447	9	distributed	distribute	VERB
admet-797	447	10	under	under	ADP
admet-797	447	11	the	the	DET
admet-797	447	12	terms	term	NOUN
admet-797	447	13	and	and	CCONJ
admet-797	447	14	conditions	condition	NOUN
admet-797	447	15	of	of	ADP
admet-797	447	16	the	the	DET
admet-797	447	17	creative	creative	ADJ
admet-797	447	18	commons	common	NOUN
admet-797	447	19	attribution	attribution	NOUN
admet-797	447	20	license	license	NOUN
admet-797	447	21	(	(	PUNCT
admet-797	447	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-797	447	23	)	)	PUNCT
admet-797	447	24	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	PROPN
admet-797	447	25	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	https://www.mhlw.go.jp/file/06-seisakujouhou-10900000-kenkoukyoku/overview.pdf	NUM
admet-797	447	26	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN