id	sid	tid	token	lemma	pos
admet-829	1	1	mechanistic	mechanistic	ADJ
admet-829	1	2	modeling	modeling	NOUN
admet-829	1	3	of	of	ADP
admet-829	1	4	gastrointestinal	gastrointestinal	ADJ
admet-829	1	5	motility	motility	NOUN
admet-829	1	6	with	with	ADP
admet-829	1	7	integrated	integrate	VERB
admet-829	1	8	dissolution	dissolution	NOUN
admet-829	1	9	for	for	ADP
admet-829	1	10	simulating	simulate	VERB
admet-829	1	11	drug	drug	NOUN
admet-829	1	12	absorption	absorption	NOUN
admet-829	1	13	doi	doi	NOUN
admet-829	1	14	:	:	PUNCT
admet-829	1	15	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	1	16	314	314	NUM
admet-829	1	17	admet	admet	PROPN
admet-829	1	18	&	&	CCONJ
admet-829	1	19	dmpk	dmpk	PROPN
admet-829	1	20	8(3	8(3	NUM
admet-829	1	21	)	)	PUNCT
admet-829	1	22	(	(	PUNCT
admet-829	1	23	2020	2020	NUM
admet-829	1	24	)	)	PUNCT
admet-829	1	25	314	314	NUM
admet-829	1	26	-	-	SYM
admet-829	1	27	324	324	NUM
admet-829	1	28	;	;	PUNCT
admet-829	1	29	doi	doi	NOUN
admet-829	1	30	:	:	PUNCT
admet-829	1	31	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	NOUN
admet-829	1	32	open	open	ADJ
admet-829	1	33	access	access	NOUN
admet-829	1	34	:	:	PUNCT
admet-829	1	35	issn	issn	PROPN
admet-829	1	36	:	:	PUNCT
admet-829	1	37	1848	1848	NUM
admet-829	1	38	-	-	SYM
admet-829	1	39	7718	7718	NUM
admet-829	1	40	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-829	1	41	original	original	ADJ
admet-829	1	42	scientific	scientific	ADJ
admet-829	1	43	paper	paper	NOUN
admet-829	1	44	mechanistic	mechanistic	ADJ
admet-829	1	45	modeling	modeling	NOUN
admet-829	1	46	of	of	ADP
admet-829	1	47	gastrointestinal	gastrointestinal	ADJ
admet-829	1	48	motility	motility	NOUN
admet-829	1	49	with	with	ADP
admet-829	1	50	integrated	integrate	VERB
admet-829	1	51	dissolution	dissolution	NOUN
admet-829	1	52	for	for	ADP
admet-829	1	53	simulating	simulate	VERB
admet-829	1	54	drug	drug	NOUN
admet-829	1	55	absorption	absorption	NOUN
admet-829	1	56	kevin	kevin	PROPN
admet-829	1	57	c.	c.	PROPN
admet-829	1	58	johnson	johnson	PROPN
admet-829	1	59	intellipharm	intellipharm	PROPN
admet-829	1	60	,	,	PUNCT
admet-829	1	61	llc	llc	PROPN
admet-829	1	62	,	,	PUNCT
admet-829	1	63	47	47	NUM
admet-829	1	64	magazine	magazine	PROPN
admet-829	1	65	street	street	PROPN
admet-829	1	66	,	,	PUNCT
admet-829	1	67	cambridge	cambridge	PROPN
admet-829	1	68	,	,	PUNCT
admet-829	1	69	ma	ma	PROPN
admet-829	1	70	02139	02139	NUM
admet-829	1	71	e	e	NOUN
admet-829	1	72	-	-	NOUN
admet-829	1	73	mail	mail	NOUN
admet-829	1	74	:	:	PUNCT
admet-829	1	75	kjohnson@intellipharm.com	kjohnson@intellipharm.com	PROPN
admet-829	1	76	received	receive	VERB
admet-829	1	77	:	:	PUNCT
admet-829	1	78	april	april	PROPN
admet-829	1	79	17	17	NUM
admet-829	1	80	,	,	PUNCT
admet-829	1	81	2020	2020	NUM
admet-829	1	82	;	;	PUNCT
admet-829	1	83	revised	revise	VERB
admet-829	1	84	:	:	PUNCT
admet-829	1	85	may	may	AUX
admet-829	1	86	31	31	NUM
admet-829	1	87	,	,	PUNCT
admet-829	1	88	2020	2020	NUM
admet-829	1	89	;	;	PUNCT
admet-829	1	90	published	publish	VERB
admet-829	1	91	:	:	PUNCT
admet-829	1	92	june	june	PROPN
admet-829	1	93	09	09	NUM
admet-829	1	94	,	,	PUNCT
admet-829	1	95	2020	2020	NUM
admet-829	1	96	abstract	abstract	ADP
admet-829	1	97	a	a	DET
admet-829	1	98	new	new	ADJ
admet-829	1	99	computational	computational	ADJ
admet-829	1	100	method	method	NOUN
admet-829	1	101	̶	̶	PROPN
admet-829	1	102	the	the	DET
admet-829	1	103	multiple	multiple	ADJ
admet-829	1	104	moving	move	VERB
admet-829	1	105	plug	plug	NOUN
admet-829	1	106	(	(	PUNCT
admet-829	1	107	mmp	mmp	PROPN
admet-829	1	108	)	)	PUNCT
admet-829	1	109	model	model	NOUN
admet-829	1	110	̶	̶	PROPN
admet-829	1	111	is	be	AUX
admet-829	1	112	described	describe	VERB
admet-829	1	113	to	to	PART
admet-829	1	114	simulate	simulate	VERB
admet-829	1	115	the	the	DET
admet-829	1	116	effect	effect	NOUN
admet-829	1	117	of	of	ADP
admet-829	1	118	gastrointestinal	gastrointestinal	ADJ
admet-829	1	119	motility	motility	NOUN
admet-829	1	120	and	and	CCONJ
admet-829	1	121	dissolution	dissolution	NOUN
admet-829	1	122	on	on	ADP
admet-829	1	123	the	the	DET
admet-829	1	124	pharmacokinetic	pharmacokinetic	ADJ
admet-829	1	125	profile	profile	NOUN
admet-829	1	126	of	of	ADP
admet-829	1	127	any	any	DET
admet-829	1	128	given	give	VERB
admet-829	1	129	drug	drug	NOUN
admet-829	1	130	.	.	PUNCT
admet-829	2	1	the	the	DET
admet-829	2	2	method	method	NOUN
admet-829	2	3	is	be	AUX
admet-829	2	4	physiologically	physiologically	ADV
admet-829	2	5	more	more	ADV
admet-829	2	6	consistent	consistent	ADJ
admet-829	2	7	with	with	ADP
admet-829	2	8	the	the	DET
admet-829	2	9	experimental	experimental	ADJ
admet-829	2	10	evidence	evidence	NOUN
admet-829	2	11	that	that	SCONJ
admet-829	2	12	fluid	fluid	NOUN
admet-829	2	13	exists	exist	VERB
admet-829	2	14	in	in	ADP
admet-829	2	15	discrete	discrete	ADJ
admet-829	2	16	plugs	plug	NOUN
admet-829	2	17	in	in	ADP
admet-829	2	18	the	the	DET
admet-829	2	19	gastrointestinal	gastrointestinal	ADJ
admet-829	2	20	tract	tract	NOUN
admet-829	2	21	,	,	PUNCT
admet-829	2	22	and	and	CCONJ
admet-829	2	23	therefore	therefore	ADV
admet-829	2	24	is	be	AUX
admet-829	2	25	more	more	ADV
admet-829	2	26	realistic	realistic	ADJ
admet-829	2	27	than	than	ADP
admet-829	2	28	modeling	model	VERB
admet-829	2	29	the	the	DET
admet-829	2	30	gastrointestinal	gastrointestinal	ADJ
admet-829	2	31	tract	tract	NOUN
admet-829	2	32	as	as	ADP
admet-829	2	33	a	a	DET
admet-829	2	34	series	series	NOUN
admet-829	2	35	of	of	ADP
admet-829	2	36	compartments	compartment	NOUN
admet-829	2	37	with	with	ADP
admet-829	2	38	first	first	ADJ
admet-829	2	39	-	-	PUNCT
admet-829	2	40	order	order	NOUN
admet-829	2	41	transfer	transfer	NOUN
admet-829	2	42	.	.	PUNCT
admet-829	3	1	the	the	DET
admet-829	3	2	number	number	NOUN
admet-829	3	3	of	of	ADP
admet-829	3	4	plugs	plug	NOUN
admet-829	3	5	used	use	VERB
admet-829	3	6	in	in	ADP
admet-829	3	7	simulations	simulation	NOUN
admet-829	3	8	,	,	PUNCT
admet-829	3	9	their	their	PRON
admet-829	3	10	gastric	gastric	ADJ
admet-829	3	11	emptying	emptying	NOUN
admet-829	3	12	times	time	NOUN
admet-829	3	13	and	and	CCONJ
admet-829	3	14	volumes	volume	NOUN
admet-829	3	15	,	,	PUNCT
admet-829	3	16	and	and	CCONJ
admet-829	3	17	their	their	PRON
admet-829	3	18	residence	residence	NOUN
admet-829	3	19	times	time	NOUN
admet-829	3	20	in	in	ADP
admet-829	3	21	the	the	DET
admet-829	3	22	small	small	ADJ
admet-829	3	23	intestine	intestine	NOUN
admet-829	3	24	can	can	AUX
admet-829	3	25	be	be	AUX
admet-829	3	26	matched	match	VERB
admet-829	3	27	with	with	ADP
admet-829	3	28	experimental	experimental	ADJ
admet-829	3	29	data	datum	NOUN
admet-829	3	30	on	on	ADP
admet-829	3	31	motility	motility	NOUN
admet-829	3	32	.	.	PUNCT
admet-829	4	1	in	in	ADP
admet-829	4	2	sample	sample	NOUN
admet-829	4	3	simulations	simulation	NOUN
admet-829	4	4	,	,	PUNCT
admet-829	4	5	drug	drug	NOUN
admet-829	4	6	absorption	absorption	NOUN
admet-829	4	7	from	from	ADP
admet-829	4	8	a	a	DET
admet-829	4	9	series	series	NOUN
admet-829	4	10	of	of	ADP
admet-829	4	11	fluid	fluid	ADJ
admet-829	4	12	plugs	plug	NOUN
admet-829	4	13	emptied	empty	VERB
admet-829	4	14	from	from	ADP
admet-829	4	15	the	the	DET
admet-829	4	16	stomach	stomach	NOUN
admet-829	4	17	at	at	ADP
admet-829	4	18	evenly	evenly	ADV
admet-829	4	19	spaced	space	VERB
admet-829	4	20	time	time	NOUN
admet-829	4	21	intervals	interval	NOUN
admet-829	4	22	showed	show	VERB
admet-829	4	23	lower	low	ADJ
admet-829	4	24	cmax	cmax	NOUN
admet-829	4	25	and	and	CCONJ
admet-829	4	26	higher	high	ADJ
admet-829	4	27	tmax	tmax	ADV
admet-829	4	28	than	than	ADP
admet-829	4	29	an	an	DET
admet-829	4	30	equivalent	equivalent	ADJ
admet-829	4	31	dose	dose	NOUN
admet-829	4	32	emptied	empty	VERB
admet-829	4	33	immediately	immediately	ADV
admet-829	4	34	as	as	ADP
admet-829	4	35	a	a	DET
admet-829	4	36	single	single	ADJ
admet-829	4	37	plug	plug	NOUN
admet-829	4	38	.	.	PUNCT
admet-829	5	1	to	to	ADP
admet-829	5	2	the	the	DET
admet-829	5	3	extent	extent	NOUN
admet-829	5	4	that	that	SCONJ
admet-829	5	5	new	new	ADJ
admet-829	5	6	techniques	technique	NOUN
admet-829	5	7	can	can	AUX
admet-829	5	8	establish	establish	VERB
admet-829	5	9	typical	typical	ADJ
admet-829	5	10	ranges	range	NOUN
admet-829	5	11	for	for	ADP
admet-829	5	12	the	the	DET
admet-829	5	13	volumes	volume	NOUN
admet-829	5	14	of	of	ADP
admet-829	5	15	fluid	fluid	NOUN
admet-829	5	16	emptied	empty	VERB
admet-829	5	17	from	from	ADP
admet-829	5	18	the	the	DET
admet-829	5	19	stomach	stomach	NOUN
admet-829	5	20	and	and	CCONJ
admet-829	5	21	their	their	PRON
admet-829	5	22	respective	respective	ADJ
admet-829	5	23	timing	timing	NOUN
admet-829	5	24	,	,	PUNCT
admet-829	5	25	the	the	DET
admet-829	5	26	mmp	mmp	PROPN
admet-829	5	27	model	model	NOUN
admet-829	5	28	may	may	AUX
admet-829	5	29	be	be	AUX
admet-829	5	30	able	able	ADJ
admet-829	5	31	to	to	PART
admet-829	5	32	predict	predict	VERB
admet-829	5	33	the	the	DET
admet-829	5	34	effect	effect	NOUN
admet-829	5	35	of	of	ADP
admet-829	5	36	gastric	gastric	ADJ
admet-829	5	37	emptying	empty	VERB
admet-829	5	38	on	on	ADP
admet-829	5	39	the	the	DET
admet-829	5	40	variability	variability	NOUN
admet-829	5	41	seen	see	VERB
admet-829	5	42	in	in	ADP
admet-829	5	43	pharmacokinetic	pharmacokinetic	ADJ
admet-829	5	44	profiles	profile	NOUN
admet-829	5	45	.	.	PUNCT
admet-829	6	1	this	this	PRON
admet-829	6	2	could	could	AUX
admet-829	6	3	lead	lead	VERB
admet-829	6	4	to	to	ADP
admet-829	6	5	an	an	DET
admet-829	6	6	expanded	expand	VERB
admet-829	6	7	safe	safe	ADJ
admet-829	6	8	space	space	NOUN
admet-829	6	9	for	for	ADP
admet-829	6	10	the	the	DET
admet-829	6	11	regulatory	regulatory	ADJ
admet-829	6	12	acceptance	acceptance	NOUN
admet-829	6	13	of	of	ADP
admet-829	6	14	formulations	formulation	NOUN
admet-829	6	15	based	base	VERB
admet-829	6	16	on	on	ADP
admet-829	6	17	dissolution	dissolution	ADJ
admet-829	6	18	data	datum	NOUN
admet-829	6	19	.	.	PUNCT
admet-829	7	1	©	©	PROPN
admet-829	7	2	2020	2020	NUM
admet-829	7	3	by	by	ADP
admet-829	7	4	the	the	DET
admet-829	7	5	authors	author	NOUN
admet-829	7	6	.	.	PUNCT
admet-829	8	1	this	this	DET
admet-829	8	2	article	article	NOUN
admet-829	8	3	is	be	AUX
admet-829	8	4	an	an	DET
admet-829	8	5	open	open	ADJ
admet-829	8	6	-	-	PUNCT
admet-829	8	7	access	access	NOUN
admet-829	8	8	article	article	NOUN
admet-829	8	9	distributed	distribute	VERB
admet-829	8	10	under	under	ADP
admet-829	8	11	the	the	DET
admet-829	8	12	terms	term	NOUN
admet-829	8	13	and	and	CCONJ
admet-829	8	14	conditions	condition	NOUN
admet-829	8	15	of	of	ADP
admet-829	8	16	the	the	DET
admet-829	8	17	creative	creative	ADJ
admet-829	8	18	commons	common	NOUN
admet-829	8	19	attribution	attribution	NOUN
admet-829	8	20	license	license	NOUN
admet-829	8	21	(	(	PUNCT
admet-829	8	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-829	8	23	)	)	PUNCT
admet-829	8	24	.	.	PUNCT
admet-829	9	1	keywords	keyword	VERB
admet-829	9	2	pbpk	pbpk	NOUN
admet-829	9	3	modeling	modeling	NOUN
admet-829	9	4	;	;	PUNCT
admet-829	9	5	gastric	gastric	ADJ
admet-829	9	6	emptying	emptying	NOUN
admet-829	9	7	;	;	PUNCT
admet-829	9	8	drug	drug	NOUN
admet-829	9	9	particle	particle	NOUN
admet-829	9	10	size	size	NOUN
admet-829	9	11	;	;	PUNCT
admet-829	9	12	multiple	multiple	ADJ
admet-829	9	13	moving	move	VERB
admet-829	9	14	plug	plug	NOUN
admet-829	9	15	model	model	NOUN
admet-829	9	16	introduction	introduction	NOUN
admet-829	9	17	several	several	ADJ
admet-829	9	18	reports	report	NOUN
admet-829	9	19	have	have	AUX
admet-829	9	20	expressed	express	VERB
admet-829	9	21	the	the	DET
admet-829	9	22	view	view	NOUN
admet-829	9	23	that	that	SCONJ
admet-829	9	24	gastrointestinal	gastrointestinal	ADJ
admet-829	9	25	(	(	PUNCT
admet-829	9	26	gi	gi	INTJ
admet-829	9	27	)	)	PUNCT
admet-829	9	28	transit	transit	NOUN
admet-829	9	29	is	be	AUX
admet-829	9	30	more	more	ADV
admet-829	9	31	realistically	realistically	ADV
admet-829	9	32	modeled	model	VERB
admet-829	9	33	as	as	ADP
admet-829	9	34	discrete	discrete	ADJ
admet-829	9	35	plugs	plug	NOUN
admet-829	9	36	of	of	ADP
admet-829	9	37	fluid	fluid	NOUN
admet-829	9	38	emptying	empty	VERB
admet-829	9	39	from	from	ADP
admet-829	9	40	the	the	DET
admet-829	9	41	stomach	stomach	NOUN
admet-829	9	42	and	and	CCONJ
admet-829	9	43	moving	move	VERB
admet-829	9	44	through	through	ADP
admet-829	9	45	the	the	DET
admet-829	9	46	small	small	ADJ
admet-829	9	47	intestine	intestine	NOUN
admet-829	9	48	rather	rather	ADV
admet-829	9	49	than	than	ADP
admet-829	9	50	as	as	ADP
admet-829	9	51	a	a	DET
admet-829	9	52	first	first	ADJ
admet-829	9	53	-	-	PUNCT
admet-829	9	54	order	order	NOUN
admet-829	9	55	process	process	NOUN
admet-829	9	56	between	between	ADP
admet-829	9	57	static	static	ADJ
admet-829	9	58	compartments	compartment	NOUN
admet-829	10	1	[	[	X
admet-829	10	2	1	1	NUM
admet-829	10	3	-	-	SYM
admet-829	10	4	3	3	NUM
admet-829	10	5	]	]	PUNCT
admet-829	10	6	.	.	PUNCT
admet-829	11	1	experimental	experimental	ADJ
admet-829	11	2	evidence	evidence	NOUN
admet-829	11	3	comes	come	VERB
admet-829	11	4	from	from	ADP
admet-829	11	5	magnetic	magnetic	ADJ
admet-829	11	6	resonance	resonance	NOUN
admet-829	11	7	imaging	imaging	NOUN
admet-829	11	8	showing	show	VERB
admet-829	11	9	isolated	isolate	VERB
admet-829	11	10	pockets	pocket	NOUN
admet-829	11	11	of	of	ADP
admet-829	11	12	fluid	fluid	NOUN
admet-829	11	13	in	in	ADP
admet-829	11	14	the	the	DET
admet-829	11	15	gi	gi	NOUN
admet-829	11	16	tract	tract	NOUN
admet-829	11	17	[	[	X
admet-829	11	18	4	4	NUM
admet-829	11	19	-	-	SYM
admet-829	11	20	6	6	NUM
admet-829	11	21	]	]	PUNCT
admet-829	11	22	.	.	PUNCT
admet-829	12	1	two	two	NUM
admet-829	12	2	of	of	ADP
admet-829	12	3	the	the	DET
admet-829	12	4	reports	report	NOUN
admet-829	12	5	[	[	X
admet-829	12	6	1,2	1,2	NUM
admet-829	12	7	]	]	PUNCT
admet-829	12	8	describe	describe	VERB
admet-829	12	9	stochastic	stochastic	ADJ
admet-829	12	10	models	model	NOUN
admet-829	12	11	for	for	ADP
admet-829	12	12	gastric	gastric	ADJ
admet-829	12	13	emptying	emptying	NOUN
admet-829	12	14	,	,	PUNCT
admet-829	12	15	but	but	CCONJ
admet-829	12	16	these	these	DET
admet-829	12	17	models	model	NOUN
admet-829	12	18	omit	omit	VERB
admet-829	12	19	the	the	DET
admet-829	12	20	effects	effect	NOUN
admet-829	12	21	of	of	ADP
admet-829	12	22	drug	drug	NOUN
admet-829	12	23	dissolution	dissolution	NOUN
admet-829	12	24	,	,	PUNCT
admet-829	12	25	absorption	absorption	NOUN
admet-829	12	26	,	,	PUNCT
admet-829	12	27	and	and	CCONJ
admet-829	12	28	metabolism	metabolism	NOUN
admet-829	12	29	on	on	ADP
admet-829	12	30	plasma	plasma	NOUN
admet-829	12	31	drug	drug	NOUN
admet-829	12	32	concentrations	concentration	NOUN
admet-829	12	33	.	.	PUNCT
admet-829	13	1	by	by	ADP
admet-829	13	2	contrast	contrast	NOUN
admet-829	13	3	,	,	PUNCT
admet-829	13	4	the	the	DET
admet-829	13	5	multiple	multiple	ADJ
admet-829	13	6	moving	move	VERB
admet-829	13	7	plug	plug	NOUN
admet-829	13	8	(	(	PUNCT
admet-829	13	9	mmp	mmp	PROPN
admet-829	13	10	)	)	PUNCT
admet-829	13	11	model	model	NOUN
admet-829	13	12	[	[	X
admet-829	13	13	3	3	X
admet-829	13	14	]	]	PUNCT
admet-829	13	15	is	be	AUX
admet-829	13	16	a	a	DET
admet-829	13	17	natural	natural	ADJ
admet-829	13	18	extension	extension	NOUN
admet-829	13	19	of	of	ADP
admet-829	13	20	a	a	DET
admet-829	13	21	well	well	ADV
admet-829	13	22	-	-	PUNCT
admet-829	13	23	established	establish	VERB
admet-829	13	24	dissolution	dissolution	NOUN
admet-829	13	25	model	model	NOUN
admet-829	13	26	[	[	X
admet-829	13	27	7	7	NUM
admet-829	13	28	-	-	SYM
admet-829	13	29	9	9	NUM
admet-829	13	30	]	]	PUNCT
admet-829	13	31	,	,	PUNCT
admet-829	13	32	the	the	DET
admet-829	13	33	default	default	NOUN
admet-829	13	34	model	model	NOUN
admet-829	13	35	in	in	ADP
admet-829	13	36	gastroplus	gastroplus	PROPN
admet-829	13	37	[	[	X
admet-829	13	38	10	10	NUM
admet-829	13	39	]	]	PUNCT
admet-829	13	40	,	,	PUNCT
admet-829	13	41	and	and	CCONJ
admet-829	13	42	can	can	AUX
admet-829	13	43	simulate	simulate	VERB
admet-829	13	44	the	the	DET
admet-829	13	45	effects	effect	NOUN
admet-829	13	46	of	of	ADP
admet-829	13	47	both	both	CCONJ
admet-829	13	48	the	the	DET
admet-829	13	49	gastric	gastric	ADJ
admet-829	13	50	emptying	emptying	NOUN
admet-829	13	51	of	of	ADP
admet-829	13	52	plugs	plug	NOUN
admet-829	13	53	and	and	CCONJ
admet-829	13	54	the	the	DET
admet-829	13	55	dissolution	dissolution	NOUN
admet-829	13	56	within	within	ADP
admet-829	13	57	the	the	DET
admet-829	13	58	plugs	plug	NOUN
admet-829	13	59	on	on	ADP
admet-829	13	60	plasma	plasma	NOUN
admet-829	13	61	drug	drug	NOUN
admet-829	13	62	concentrations	concentration	NOUN
admet-829	13	63	.	.	PUNCT
admet-829	14	1	the	the	DET
admet-829	14	2	mmp	mmp	PROPN
admet-829	14	3	model	model	NOUN
admet-829	14	4	is	be	AUX
admet-829	14	5	capable	capable	ADJ
admet-829	14	6	of	of	ADP
admet-829	14	7	utilizing	utilize	VERB
admet-829	14	8	either	either	CCONJ
admet-829	14	9	experimental	experimental	ADJ
admet-829	14	10	data	datum	NOUN
admet-829	14	11	or	or	CCONJ
admet-829	14	12	stochastic	stochastic	ADJ
admet-829	14	13	simulations	simulation	NOUN
admet-829	14	14	of	of	ADP
admet-829	14	15	the	the	DET
admet-829	14	16	volumes	volume	NOUN
admet-829	14	17	and	and	CCONJ
admet-829	14	18	timing	timing	NOUN
admet-829	14	19	of	of	ADP
admet-829	14	20	plugs	plug	NOUN
admet-829	14	21	emptying	empty	VERB
admet-829	14	22	from	from	ADP
admet-829	14	23	the	the	DET
admet-829	14	24	stomach	stomach	NOUN
admet-829	14	25	.	.	PUNCT
admet-829	15	1	the	the	DET
admet-829	15	2	computational	computational	ADJ
admet-829	15	3	method	method	NOUN
admet-829	15	4	of	of	ADP
admet-829	15	5	the	the	DET
admet-829	15	6	mmp	mmp	PROPN
admet-829	15	7	model	model	NOUN
admet-829	15	8	is	be	AUX
admet-829	15	9	described	describe	VERB
admet-829	15	10	here	here	ADV
admet-829	15	11	in	in	ADP
admet-829	15	12	more	more	ADV
admet-829	15	13	rigorous	rigorous	ADJ
admet-829	15	14	mathematical	mathematical	ADJ
admet-829	15	15	detail	detail	NOUN
admet-829	15	16	than	than	SCONJ
admet-829	15	17	previously	previously	ADV
admet-829	15	18	discussed	discuss	VERB
admet-829	15	19	[	[	X
admet-829	15	20	3	3	NUM
admet-829	15	21	]	]	PUNCT
admet-829	15	22	.	.	PUNCT
admet-829	16	1	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	16	2	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	16	3	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-829	16	4	mailto:kjohnson@intellipharm.com	mailto:kjohnson@intellipharm.com	X
admet-829	16	5	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-829	16	6	admet	admet	PROPN
admet-829	16	7	&	&	CCONJ
admet-829	16	8	dmpk	dmpk	PROPN
admet-829	16	9	8(3	8(3	NUM
admet-829	16	10	)	)	PUNCT
admet-829	16	11	(	(	PUNCT
admet-829	16	12	2020	2020	NUM
admet-829	16	13	)	)	PUNCT
admet-829	16	14	314	314	NUM
admet-829	16	15	-	-	SYM
admet-829	16	16	324	324	NUM
admet-829	16	17	mechanistic	mechanistic	ADJ
admet-829	16	18	modeling	modeling	NOUN
admet-829	16	19	of	of	ADP
admet-829	16	20	gastrointestinal	gastrointestinal	ADJ
admet-829	16	21	motility	motility	NOUN
admet-829	16	22	doi	doi	NOUN
admet-829	16	23	:	:	PUNCT
admet-829	16	24	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	16	25	315	315	NUM
admet-829	16	26	sample	sample	NOUN
admet-829	16	27	simulations	simulation	NOUN
admet-829	16	28	show	show	VERB
admet-829	16	29	the	the	DET
admet-829	16	30	effects	effect	NOUN
admet-829	16	31	of	of	ADP
admet-829	16	32	gastric	gastric	ADJ
admet-829	16	33	emptying	empty	VERB
admet-829	16	34	on	on	ADP
admet-829	16	35	the	the	DET
admet-829	16	36	pharmacokinetics	pharmacokinetic	NOUN
admet-829	16	37	of	of	ADP
admet-829	16	38	a	a	DET
admet-829	16	39	hypothetical	hypothetical	ADJ
admet-829	16	40	drug	drug	NOUN
admet-829	16	41	.	.	PUNCT
admet-829	17	1	computational	computational	ADJ
admet-829	17	2	method	method	NOUN
admet-829	17	3	a	a	DET
admet-829	17	4	system	system	NOUN
admet-829	17	5	of	of	ADP
admet-829	17	6	coupled	couple	VERB
admet-829	17	7	differential	differential	ADJ
admet-829	17	8	equations	equation	NOUN
admet-829	17	9	describing	describe	VERB
admet-829	17	10	drug	drug	NOUN
admet-829	17	11	dissolution	dissolution	NOUN
admet-829	17	12	,	,	PUNCT
admet-829	17	13	absorption	absorption	NOUN
admet-829	17	14	,	,	PUNCT
admet-829	17	15	and	and	CCONJ
admet-829	17	16	metabolism	metabolism	NOUN
admet-829	17	17	was	be	AUX
admet-829	17	18	solved	solve	VERB
admet-829	17	19	numerically	numerically	ADV
admet-829	17	20	using	use	VERB
admet-829	17	21	the	the	DET
admet-829	17	22	fourth	fourth	ADJ
admet-829	17	23	-	-	PUNCT
admet-829	17	24	order	order	NOUN
admet-829	17	25	runge	runge	NOUN
admet-829	17	26	-	-	PUNCT
admet-829	17	27	kutta	kutta	NOUN
admet-829	17	28	method	method	NOUN
admet-829	17	29	.	.	PUNCT
admet-829	18	1	development	development	NOUN
admet-829	18	2	of	of	ADP
admet-829	18	3	this	this	DET
admet-829	18	4	system	system	NOUN
admet-829	18	5	has	have	AUX
admet-829	18	6	been	be	AUX
admet-829	18	7	described	describe	VERB
admet-829	18	8	previously	previously	ADV
admet-829	18	9	as	as	ADV
admet-829	18	10	well	well	ADV
admet-829	18	11	as	as	ADP
admet-829	18	12	the	the	DET
admet-829	18	13	derivation	derivation	NOUN
admet-829	18	14	of	of	ADP
admet-829	18	15	the	the	DET
admet-829	18	16	noyes	noyes	PROPN
admet-829	18	17	-	-	PUNCT
admet-829	18	18	whitney	whitney	PROPN
admet-829	18	19	equation	equation	NOUN
admet-829	18	20	assuming	assume	VERB
admet-829	18	21	spherical	spherical	ADJ
admet-829	18	22	drug	drug	NOUN
admet-829	18	23	particle	particle	NOUN
admet-829	18	24	geometry	geometry	NOUN
admet-829	18	25	[	[	X
admet-829	18	26	3,7,8	3,7,8	NUM
admet-829	18	27	]	]	PUNCT
admet-829	18	28	.	.	PUNCT
admet-829	19	1	the	the	DET
admet-829	19	2	equations	equation	NOUN
admet-829	19	3	used	use	VERB
admet-829	19	4	are	be	AUX
admet-829	19	5	summarized	summarize	VERB
admet-829	19	6	in	in	ADP
admet-829	19	7	table	table	NOUN
admet-829	19	8	1	1	NUM
admet-829	19	9	including	include	VERB
admet-829	19	10	the	the	DET
admet-829	19	11	definitions	definition	NOUN
admet-829	19	12	of	of	ADP
admet-829	19	13	variables	variable	NOUN
admet-829	19	14	and	and	CCONJ
admet-829	19	15	parameters	parameter	NOUN
admet-829	19	16	.	.	PUNCT
admet-829	20	1	new	new	ADJ
admet-829	20	2	is	be	AUX
admet-829	20	3	the	the	DET
admet-829	20	4	addition	addition	NOUN
admet-829	20	5	of	of	ADP
admet-829	20	6	the	the	DET
admet-829	20	7	index	index	NOUN
admet-829	20	8	j	j	PROPN
admet-829	20	9	to	to	PART
admet-829	20	10	create	create	VERB
admet-829	20	11	and	and	CCONJ
admet-829	20	12	track	track	VERB
admet-829	20	13	discrete	discrete	ADJ
admet-829	20	14	plugs	plug	NOUN
admet-829	20	15	that	that	PRON
admet-829	20	16	move	move	VERB
admet-829	20	17	independently	independently	ADV
admet-829	20	18	through	through	ADP
admet-829	20	19	the	the	DET
admet-829	20	20	gi	gi	PROPN
admet-829	20	21	tract	tract	NOUN
admet-829	20	22	as	as	SCONJ
admet-829	20	23	illustrated	illustrate	VERB
admet-829	20	24	in	in	ADP
admet-829	20	25	figure	figure	NOUN
admet-829	20	26	1	1	NUM
admet-829	20	27	.	.	PUNCT
admet-829	21	1	it	it	PRON
admet-829	21	2	should	should	AUX
admet-829	21	3	be	be	AUX
admet-829	21	4	noted	note	VERB
admet-829	21	5	that	that	SCONJ
admet-829	21	6	figure	figure	NOUN
admet-829	21	7	1	1	NUM
admet-829	21	8	was	be	AUX
admet-829	21	9	drawn	draw	VERB
admet-829	21	10	to	to	PART
admet-829	21	11	show	show	VERB
admet-829	21	12	a	a	DET
admet-829	21	13	reasonably	reasonably	ADV
admet-829	21	14	realistic	realistic	ADJ
admet-829	21	15	length	length	NOUN
admet-829	21	16	-	-	PUNCT
admet-829	21	17	to	to	ADP
admet-829	21	18	-	-	PUNCT
admet-829	21	19	diameter	diameter	NOUN
admet-829	21	20	ratio	ratio	NOUN
admet-829	21	21	for	for	ADP
admet-829	21	22	the	the	DET
admet-829	21	23	small	small	ADJ
admet-829	21	24	intestine	intestine	NOUN
admet-829	21	25	and	and	CCONJ
admet-829	21	26	was	be	AUX
admet-829	21	27	untangled	untangle	VERB
admet-829	21	28	to	to	PART
admet-829	21	29	facilitate	facilitate	VERB
admet-829	21	30	this	this	DET
admet-829	21	31	perspective	perspective	NOUN
admet-829	22	1	[	[	X
admet-829	22	2	11	11	NUM
admet-829	22	3	]	]	PUNCT
admet-829	22	4	.	.	PUNCT
admet-829	23	1	in	in	ADP
admet-829	23	2	reality	reality	NOUN
admet-829	23	3	,	,	PUNCT
admet-829	23	4	the	the	DET
admet-829	23	5	small	small	ADJ
admet-829	23	6	intestine	intestine	NOUN
admet-829	23	7	must	must	AUX
admet-829	23	8	be	be	AUX
admet-829	23	9	much	much	ADV
admet-829	23	10	more	more	ADV
admet-829	23	11	convoluted	convoluted	ADJ
admet-829	23	12	to	to	PART
admet-829	23	13	fit	fit	VERB
admet-829	23	14	into	into	ADP
admet-829	23	15	the	the	DET
admet-829	23	16	small	small	ADJ
admet-829	23	17	space	space	NOUN
admet-829	23	18	of	of	ADP
admet-829	23	19	the	the	DET
admet-829	23	20	abdominal	abdominal	ADJ
admet-829	23	21	cavity	cavity	NOUN
admet-829	23	22	.	.	PUNCT
admet-829	24	1	independence	independence	NOUN
admet-829	24	2	is	be	AUX
admet-829	24	3	achieved	achieve	VERB
admet-829	24	4	by	by	ADP
admet-829	24	5	making	make	VERB
admet-829	24	6	plug	plug	VERB
admet-829	24	7	-	-	PUNCT
admet-829	24	8	specific	specific	ADJ
admet-829	24	9	initial	initial	ADJ
admet-829	24	10	conditions	condition	NOUN
admet-829	24	11	and	and	CCONJ
admet-829	24	12	time-/position	time-/position	NOUN
admet-829	24	13	-	-	PUNCT
admet-829	24	14	dependent	dependent	ADJ
admet-829	24	15	changes	change	NOUN
admet-829	24	16	to	to	ADP
admet-829	24	17	variables	variable	NOUN
admet-829	24	18	associated	associate	VERB
admet-829	24	19	with	with	ADP
admet-829	24	20	each	each	DET
admet-829	24	21	plug	plug	NOUN
admet-829	24	22	.	.	PUNCT
admet-829	25	1	increasing	increase	VERB
admet-829	25	2	the	the	DET
admet-829	25	3	number	number	NOUN
admet-829	25	4	of	of	ADP
admet-829	25	5	plugs	plug	NOUN
admet-829	25	6	allows	allow	VERB
admet-829	25	7	more	more	ADJ
admet-829	25	8	refined	refined	ADJ
admet-829	25	9	simulation	simulation	NOUN
admet-829	25	10	of	of	ADP
admet-829	25	11	localized	localize	VERB
admet-829	25	12	gi	gi	NOUN
admet-829	25	13	events	event	NOUN
admet-829	25	14	and	and	CCONJ
admet-829	25	15	the	the	DET
admet-829	25	16	resulting	result	VERB
admet-829	25	17	variability	variability	NOUN
admet-829	25	18	in	in	ADP
admet-829	25	19	drug	drug	NOUN
admet-829	25	20	plasma	plasma	NOUN
admet-829	25	21	concentrations	concentration	NOUN
admet-829	25	22	.	.	PUNCT
admet-829	26	1	a	a	DET
admet-829	26	2	specific	specific	ADJ
admet-829	26	3	example	example	NOUN
admet-829	26	4	of	of	ADP
admet-829	26	5	the	the	DET
admet-829	26	6	microsoft	microsoft	PROPN
admet-829	26	7	visual	visual	PROPN
admet-829	26	8	basic	basic	PROPN
admet-829	26	9	code	code	NOUN
admet-829	26	10	used	use	VERB
admet-829	26	11	for	for	ADP
admet-829	26	12	the	the	DET
admet-829	26	13	simulations	simulation	NOUN
admet-829	26	14	is	be	AUX
admet-829	26	15	available	available	ADJ
admet-829	26	16	at	at	ADP
admet-829	26	17	https://intellipharm.com/wp-content/uploads/2020/04/mmp.txt	https://intellipharm.com/wp-content/uploads/2020/04/mmp.txt	PROPN
admet-829	26	18	.	.	PUNCT
admet-829	27	1	reference	reference	NOUN
admet-829	27	2	3	3	NUM
admet-829	27	3	provides	provide	VERB
admet-829	27	4	a	a	DET
admet-829	27	5	general	general	ADJ
admet-829	27	6	explanation	explanation	NOUN
admet-829	27	7	of	of	ADP
admet-829	27	8	the	the	DET
admet-829	27	9	coding	code	VERB
admet-829	27	10	techniques	technique	NOUN
admet-829	27	11	applied	apply	VERB
admet-829	27	12	to	to	ADP
admet-829	27	13	the	the	DET
admet-829	27	14	mmp	mmp	PROPN
admet-829	27	15	model	model	PROPN
admet-829	27	16	.	.	PUNCT
admet-829	28	1	figure	figure	NOUN
admet-829	28	2	1	1	NUM
admet-829	28	3	.	.	PUNCT
admet-829	29	1	drawing	draw	VERB
admet-829	29	2	of	of	ADP
admet-829	29	3	the	the	DET
admet-829	29	4	gi	gi	PROPN
admet-829	29	5	tract	tract	NOUN
admet-829	29	6	illustrating	illustrate	VERB
admet-829	29	7	multiple	multiple	ADJ
admet-829	29	8	moving	move	VERB
admet-829	29	9	plugs	plug	NOUN
admet-829	29	10	of	of	ADP
admet-829	29	11	fluid	fluid	NOUN
admet-829	29	12	.	.	PUNCT
admet-829	30	1	in	in	ADP
admet-829	30	2	the	the	DET
admet-829	30	3	simulations	simulation	NOUN
admet-829	30	4	for	for	ADP
admet-829	30	5	figures	figure	NOUN
admet-829	30	6	2	2	NUM
admet-829	30	7	-	-	SYM
admet-829	30	8	4	4	NUM
admet-829	30	9	,	,	PUNCT
admet-829	30	10	the	the	DET
admet-829	30	11	first	first	ADJ
admet-829	30	12	plug	plug	NOUN
admet-829	30	13	(	(	PUNCT
admet-829	30	14	j=1	j=1	NOUN
admet-829	30	15	)	)	PUNCT
admet-829	30	16	to	to	PART
admet-829	30	17	empty	empty	VERB
admet-829	30	18	from	from	ADP
admet-829	30	19	the	the	DET
admet-829	30	20	stomach	stomach	NOUN
admet-829	30	21	at	at	ADP
admet-829	30	22	time	time	NOUN
admet-829	30	23	zero	zero	NUM
admet-829	30	24	is	be	AUX
admet-829	30	25	shown	show	VERB
admet-829	30	26	in	in	ADP
admet-829	30	27	red	red	ADJ
admet-829	30	28	,	,	PUNCT
admet-829	30	29	the	the	DET
admet-829	30	30	second	second	ADJ
admet-829	30	31	(	(	PUNCT
admet-829	30	32	j=2	j=2	NOUN
admet-829	30	33	)	)	PUNCT
admet-829	30	34	at	at	ADP
admet-829	30	35	15	15	NUM
admet-829	30	36	minutes	minute	NOUN
admet-829	30	37	is	be	AUX
admet-829	30	38	shown	show	VERB
admet-829	30	39	in	in	ADP
admet-829	30	40	blue	blue	ADJ
admet-829	30	41	,	,	PUNCT
admet-829	30	42	and	and	CCONJ
admet-829	30	43	the	the	DET
admet-829	30	44	third	third	ADJ
admet-829	30	45	(	(	PUNCT
admet-829	30	46	j=3	j=3	PROPN
admet-829	30	47	)	)	PUNCT
admet-829	30	48	at	at	ADP
admet-829	30	49	30	30	NUM
admet-829	30	50	minutes	minute	NOUN
admet-829	30	51	is	be	AUX
admet-829	30	52	shown	show	VERB
admet-829	30	53	in	in	ADP
admet-829	30	54	green	green	ADJ
admet-829	30	55	.	.	PUNCT
admet-829	31	1	a	a	DET
admet-829	31	2	step	step	NOUN
admet-829	31	3	size	size	NOUN
admet-829	31	4	of	of	ADP
admet-829	31	5	0.001	0.001	NUM
admet-829	31	6	minute	minute	NOUN
admet-829	31	7	was	be	AUX
admet-829	31	8	used	use	VERB
admet-829	31	9	for	for	ADP
admet-829	31	10	the	the	DET
admet-829	31	11	runge	runge	NOUN
admet-829	31	12	-	-	PUNCT
admet-829	31	13	kutta	kutta	NOUN
admet-829	31	14	method	method	NOUN
admet-829	31	15	.	.	PUNCT
admet-829	32	1	the	the	DET
admet-829	32	2	iterative	iterative	ADJ
admet-829	32	3	nature	nature	NOUN
admet-829	32	4	of	of	ADP
admet-829	32	5	this	this	DET
admet-829	32	6	method	method	NOUN
admet-829	32	7	allows	allow	VERB
admet-829	32	8	any	any	DET
admet-829	32	9	parameter	parameter	NOUN
admet-829	32	10	to	to	PART
admet-829	32	11	be	be	AUX
admet-829	32	12	changed	change	VERB
admet-829	32	13	at	at	ADP
admet-829	32	14	a	a	DET
admet-829	32	15	frequency	frequency	NOUN
admet-829	32	16	equal	equal	ADJ
admet-829	32	17	to	to	ADP
admet-829	32	18	the	the	DET
admet-829	32	19	step	step	NOUN
admet-829	32	20	size	size	NOUN
admet-829	32	21	.	.	PUNCT
admet-829	33	1	equations	equation	NOUN
admet-829	33	2	1	1	NUM
admet-829	33	3	-	-	SYM
admet-829	33	4	4	4	NUM
admet-829	33	5	describe	describe	VERB
admet-829	33	6	how	how	SCONJ
admet-829	33	7	drug	drug	NOUN
admet-829	33	8	mass	mass	NOUN
admet-829	33	9	changes	change	NOUN
admet-829	33	10	in	in	ADP
admet-829	33	11	various	various	ADJ
admet-829	33	12	locations	location	NOUN
admet-829	33	13	,	,	PUNCT
admet-829	33	14	but	but	CCONJ
admet-829	33	15	other	other	ADJ
admet-829	33	16	parameters	parameter	NOUN
admet-829	33	17	can	can	AUX
admet-829	33	18	be	be	AUX
admet-829	33	19	changed	change	VERB
admet-829	33	20	to	to	PART
admet-829	33	21	match	match	VERB
admet-829	33	22	the	the	DET
admet-829	33	23	physical	physical	ADJ
admet-829	33	24	characteristics	characteristic	NOUN
admet-829	33	25	of	of	ADP
admet-829	33	26	the	the	DET
admet-829	33	27	location	location	NOUN
admet-829	33	28	.	.	PUNCT
admet-829	34	1	for	for	ADP
admet-829	34	2	example	example	NOUN
admet-829	34	3	,	,	PUNCT
admet-829	34	4	it	it	PRON
admet-829	34	5	has	have	AUX
admet-829	34	6	already	already	ADV
admet-829	34	7	been	be	AUX
admet-829	34	8	described	describe	VERB
admet-829	34	9	how	how	SCONJ
admet-829	34	10	hij	hij	NOUN
admet-829	34	11	changes	change	VERB
admet-829	34	12	with	with	ADP
admet-829	34	13	a	a	DET
admet-829	34	14	change	change	NOUN
admet-829	34	15	in	in	ADP
admet-829	34	16	drug	drug	NOUN
admet-829	34	17	particle	particle	NOUN
admet-829	34	18	radius	radius	NOUN
admet-829	34	19	as	as	SCONJ
admet-829	34	20	particles	particle	NOUN
admet-829	34	21	dissolve	dissolve	VERB
admet-829	34	22	[	[	X
admet-829	34	23	3,7,8	3,7,8	NUM
admet-829	34	24	]	]	X
admet-829	34	25	.	.	PUNCT
admet-829	35	1	because	because	SCONJ
admet-829	35	2	the	the	DET
admet-829	35	3	number	number	NOUN
admet-829	35	4	of	of	ADP
admet-829	35	5	parameter	parameter	NOUN
admet-829	35	6	changes	change	NOUN
admet-829	35	7	that	that	PRON
admet-829	35	8	could	could	AUX
admet-829	35	9	be	be	AUX
admet-829	35	10	simulated	simulate	VERB
admet-829	35	11	is	be	AUX
admet-829	35	12	unlimited	unlimited	ADJ
admet-829	35	13	,	,	PUNCT
admet-829	35	14	only	only	ADV
admet-829	35	15	kaj	kaj	PROPN
admet-829	35	16	was	be	AUX
admet-829	35	17	altered	alter	VERB
admet-829	35	18	to	to	PART
admet-829	35	19	explore	explore	VERB
admet-829	35	20	the	the	DET
admet-829	35	21	potential	potential	ADJ
admet-829	35	22	effect	effect	NOUN
admet-829	35	23	of	of	ADP
admet-829	35	24	gastric	gastric	ADJ
admet-829	35	25	emptying	empty	VERB
admet-829	35	26	on	on	ADP
admet-829	35	27	the	the	DET
admet-829	35	28	drug	drug	NOUN
admet-829	35	29	plasma	plasma	NOUN
admet-829	35	30	concentration	concentration	NOUN
admet-829	35	31	profile	profile	NOUN
admet-829	35	32	.	.	PUNCT
admet-829	36	1	table	table	NOUN
admet-829	36	2	2	2	NUM
admet-829	36	3	lists	list	VERB
admet-829	36	4	the	the	DET
admet-829	36	5	other	other	ADJ
admet-829	36	6	parameters	parameter	NOUN
admet-829	36	7	used	use	VERB
admet-829	36	8	in	in	ADP
admet-829	36	9	the	the	DET
admet-829	36	10	simulations	simulation	NOUN
admet-829	36	11	that	that	PRON
admet-829	36	12	were	be	AUX
admet-829	36	13	held	hold	VERB
admet-829	36	14	constant	constant	ADJ
admet-829	36	15	.	.	PUNCT
admet-829	37	1	they	they	PRON
admet-829	37	2	are	be	AUX
admet-829	37	3	similar	similar	ADJ
admet-829	37	4	to	to	ADP
admet-829	37	5	the	the	DET
admet-829	37	6	values	value	NOUN
admet-829	37	7	reported	report	VERB
admet-829	37	8	for	for	ADP
admet-829	37	9	nifedipine	nifedipine	NOUN
admet-829	37	10	[	[	X
admet-829	37	11	12	12	NUM
admet-829	37	12	]	]	PUNCT
admet-829	37	13	.	.	PUNCT
admet-829	38	1	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	38	2	https://intellipharm.com/wp-content/uploads/2020/04/mmp.txt	https://intellipharm.com/wp-content/uploads/2020/04/mmp.txt	PROPN
admet-829	38	3	kevin	kevin	PROPN
admet-829	38	4	c.	c.	PROPN
admet-829	38	5	johnson	johnson	PROPN
admet-829	38	6	admet	admet	PROPN
admet-829	38	7	&	&	CCONJ
admet-829	38	8	dmpk	dmpk	PROPN
admet-829	38	9	8(3	8(3	NUM
admet-829	38	10	)	)	PUNCT
admet-829	38	11	(	(	PUNCT
admet-829	38	12	2020	2020	NUM
admet-829	38	13	)	)	PUNCT
admet-829	38	14	314	314	NUM
admet-829	38	15	-	-	SYM
admet-829	38	16	324	324	NUM
admet-829	38	17	316	316	NUM
admet-829	38	18	table	table	NOUN
admet-829	38	19	1	1	NUM
admet-829	38	20	.	.	PUNCT
admet-829	38	21	differential	differential	ADJ
admet-829	38	22	equations	equation	NOUN
admet-829	38	23	and	and	CCONJ
admet-829	38	24	symbol	symbol	NOUN
admet-829	38	25	definitions	definition	NOUN
admet-829	38	26	for	for	ADP
admet-829	38	27	the	the	DET
admet-829	38	28	multiple	multiple	ADJ
admet-829	38	29	moving	move	VERB
admet-829	38	30	plug	plug	NOUN
admet-829	38	31	model	model	NOUN
admet-829	38	32	.	.	PUNCT
admet-829	39	1	quantity	quantity	NOUN
admet-829	39	2	being	be	AUX
admet-829	39	3	tracked	track	VERB
admet-829	39	4	equation	equation	NOUN
admet-829	39	5	solid	solid	ADJ
admet-829	39	6	drug	drug	NOUN
admet-829	39	7	mass	mass	NOUN
admet-829	39	8	(	(	PUNCT
admet-829	39	9	mg	mg	PROPN
admet-829	39	10	)	)	PUNCT
admet-829	39	11	in	in	ADP
admet-829	39	12	the	the	DET
admet-829	39	13	gi	gi	NOUN
admet-829	39	14	tract	tract	NOUN
admet-829	39	15	in	in	ADP
admet-829	39	16	plug	plug	NOUN
admet-829	39	17	j	j	PROPN
admet-829	39	18	from	from	ADP
admet-829	39	19	particle	particle	NOUN
admet-829	39	20	size	size	NOUN
admet-829	39	21	fraction	fraction	NOUN
admet-829	39	22	i	i	PRON
admet-829	39	23	2	2	NUM
admet-829	39	24	33	33	NUM
admet-829	39	25	1	1	NUM
admet-829	39	26	3	3	NUM
admet-829	39	27	tij	tij	NOUN
admet-829	39	28	ij	ij	INTJ
admet-829	39	29	ij	ij	INTJ
admet-829	39	30	j	j	PROPN
admet-829	40	1	j	j	INTJ
admet-829	41	1	i	i	PRON
admet-829	41	2	ds	ds	VERB
admet-829	41	3	o	o	NOUN
admet-829	41	4	s	s	X
admet-829	41	5	s	s	X
admet-829	41	6	j	j	NOUN
admet-829	42	1	o	o	X
admet-829	42	2	j	j	PROPN
admet-829	43	1	d	d	X
admet-829	43	2	d	d	X
admet-829	43	3	i	i	PRON
admet-829	43	4	dx	dx	VERB
admet-829	43	5	x	x	INTJ
admet-829	44	1	xx	xx	NUM
admet-829	44	2	c	c	NOUN
admet-829	44	3	t	t	NOUN
admet-829	45	1	h	h	NOUN
admet-829	46	1	r	r	NOUN
admet-829	46	2	v	v	NOUN
admet-829	46	3	(	(	PUNCT
admet-829	46	4	1	1	NUM
admet-829	46	5	)	)	PUNCT
admet-829	46	6	dissolved	dissolve	VERB
admet-829	46	7	drug	drug	NOUN
admet-829	46	8	mass	mass	NOUN
admet-829	46	9	(	(	PUNCT
admet-829	46	10	mg	mg	PROPN
admet-829	46	11	)	)	PUNCT
admet-829	46	12	in	in	ADP
admet-829	46	13	the	the	DET
admet-829	46	14	gi	gi	NOUN
admet-829	46	15	tract	tract	NOUN
admet-829	46	16	in	in	ADP
admet-829	46	17	plug	plug	NOUN
admet-829	46	18	j	j	PROPN
admet-829	46	19	from	from	ADP
admet-829	46	20	particle	particle	NOUN
admet-829	46	21	size	size	NOUN
admet-829	46	22	fraction	fraction	NOUN
admet-829	46	23	i	i	PRON
admet-829	46	24	1	1	NUM
admet-829	46	25	2	2	NUM
admet-829	46	26	3	3	NUM
admet-829	46	27	33	33	NUM
admet-829	46	28	tij	tij	NOUN
admet-829	46	29	ij	ij	INTJ
admet-829	46	30	j	j	PROPN
admet-829	46	31	j	j	PROPN
admet-829	47	1	j	j	PROPN
admet-829	47	2	ij	ij	INTJ
admet-829	47	3	i	i	PRON
admet-829	47	4	do	do	VERB
admet-829	47	5	s	s	PRON
admet-829	47	6	s	s	PROPN
admet-829	47	7	a	a	PRON
admet-829	47	8	d	d	X
admet-829	47	9	ij	ij	NOUN
admet-829	48	1	o	o	X
admet-829	48	2	j	j	PROPN
admet-829	49	1	d	d	X
admet-829	49	2	d	d	X
admet-829	49	3	ijd	ijd	PROPN
admet-829	49	4	dx	dx	PROPN
admet-829	49	5	x	x	PUNCT
admet-829	50	1	xx	xx	NUM
admet-829	50	2	c	c	NOUN
admet-829	50	3	k	k	NOUN
admet-829	50	4	x	x	SYM
admet-829	51	1	t	t	NOUN
admet-829	51	2	h	h	NOUN
admet-829	51	3	r	r	NOUN
admet-829	51	4	v	v	NOUN
admet-829	51	5	(	(	PUNCT
admet-829	51	6	2	2	NUM
admet-829	51	7	)	)	PUNCT
admet-829	51	8	drug	drug	NOUN
admet-829	51	9	mass	mass	NOUN
admet-829	51	10	(	(	PUNCT
admet-829	51	11	mg	mg	PROPN
admet-829	51	12	)	)	PUNCT
admet-829	51	13	in	in	ADP
admet-829	51	14	the	the	DET
admet-829	51	15	plasma	plasma	NOUN
admet-829	51	16	compartment	compartment	NOUN
admet-829	51	17	originating	originate	VERB
admet-829	51	18	from	from	ADP
admet-829	51	19	particle	particle	NOUN
admet-829	51	20	size	size	NOUN
admet-829	51	21	fraction	fraction	NOUN
admet-829	52	1	i	i	PRON
admet-829	52	2	in	in	ADP
admet-829	52	3	plug	plug	NOUN
admet-829	52	4	j	j	NOUN
admet-829	52	5	1	1	NUM
admet-829	52	6	1	1	NUM
admet-829	52	7	21	21	NUM
admet-829	52	8	2	2	NUM
admet-829	52	9	ij	ij	NOUN
admet-829	52	10	j	j	PROPN
admet-829	53	1	ij	ij	INTJ
admet-829	53	2	ij	ij	INTJ
admet-829	53	3	ija	ija	PROPN
admet-829	53	4	j	j	PROPN
admet-829	54	1	d	d	PROPN
admet-829	54	2	12	12	NUM
admet-829	54	3	d	d	NOUN
admet-829	54	4	d	d	PROPN
admet-829	54	5	d	d	X
admet-829	54	6	y	y	PROPN
admet-829	54	7	cl	cl	NOUN
admet-829	55	1	k	k	NOUN
admet-829	56	1	f	f	PUNCT
admet-829	56	2	x	x	X
admet-829	57	1	k	k	PROPN
admet-829	57	2	y	y	PROPN
admet-829	57	3	k	k	PROPN
admet-829	58	1	y	y	PROPN
admet-829	58	2	t	t	PROPN
admet-829	58	3	v	v	PROPN
admet-829	58	4	(	(	PUNCT
admet-829	58	5	3	3	NUM
admet-829	58	6	)	)	PUNCT
admet-829	58	7	drug	drug	NOUN
admet-829	58	8	mass	mass	NOUN
admet-829	58	9	(	(	PUNCT
admet-829	58	10	mg	mg	PROPN
admet-829	58	11	)	)	PUNCT
admet-829	58	12	in	in	ADP
admet-829	58	13	the	the	DET
admet-829	58	14	tissue	tissue	NOUN
admet-829	58	15	compartment	compartment	NOUN
admet-829	58	16	originating	originate	VERB
admet-829	58	17	from	from	ADP
admet-829	58	18	particle	particle	NOUN
admet-829	58	19	size	size	NOUN
admet-829	58	20	fraction	fraction	NOUN
admet-829	58	21	i	i	PRON
admet-829	58	22	in	in	ADP
admet-829	58	23	plug	plug	NOUN
admet-829	58	24	j	j	PROPN
admet-829	58	25	2	2	NUM
admet-829	58	26	12	12	NUM
admet-829	58	27	1	1	NUM
admet-829	58	28	21	21	NUM
admet-829	58	29	2	2	NUM
admet-829	58	30	ij	ij	NUM
admet-829	58	31	ij	ij	INTJ
admet-829	58	32	ij	ij	INTJ
admet-829	59	1	d	d	NOUN
admet-829	59	2	d	d	X
admet-829	59	3	y	y	PROPN
admet-829	59	4	k	k	PROPN
admet-829	59	5	y	y	PROPN
admet-829	59	6	k	k	PROPN
admet-829	59	7	y	y	PROPN
admet-829	59	8	t	t	PROPN
admet-829	59	9	(	(	PUNCT
admet-829	59	10	4	4	NUM
admet-829	59	11	)	)	PUNCT
admet-829	59	12	total	total	ADJ
admet-829	59	13	mass	mass	NOUN
admet-829	59	14	of	of	ADP
admet-829	59	15	dissolved	dissolve	VERB
admet-829	59	16	drug	drug	NOUN
admet-829	59	17	(	(	PUNCT
admet-829	59	18	mg	mg	PROPN
admet-829	59	19	)	)	PUNCT
admet-829	59	20	in	in	ADP
admet-829	59	21	plug	plug	NOUN
admet-829	59	22	j	j	PROPN
admet-829	59	23	from	from	ADP
admet-829	59	24	all	all	DET
admet-829	59	25	particle	particle	NOUN
admet-829	59	26	size	size	NOUN
admet-829	59	27	fractions	fraction	NOUN
admet-829	59	28	1	1	NUM
admet-829	59	29	t	t	NOUN
admet-829	59	30	ijj	ijj	NOUN
admet-829	60	1	i	i	PRON
admet-829	60	2	d	d	PROPN
admet-829	61	1	d	d	VERB
admet-829	61	2	i	i	PRON
admet-829	61	3	n	n	NOUN
admet-829	61	4	x	x	NOUN
admet-829	61	5	x	x	X
admet-829	61	6	(	(	PUNCT
admet-829	61	7	5	5	NUM
admet-829	61	8	)	)	PUNCT
admet-829	61	9	total	total	ADJ
admet-829	61	10	drug	drug	NOUN
admet-829	61	11	mass	mass	NOUN
admet-829	61	12	(	(	PUNCT
admet-829	61	13	mg	mg	PROPN
admet-829	61	14	)	)	PUNCT
admet-829	61	15	in	in	ADP
admet-829	61	16	the	the	DET
admet-829	61	17	plasma	plasma	NOUN
admet-829	61	18	compartment	compartment	NOUN
admet-829	61	19	from	from	ADP
admet-829	61	20	all	all	DET
admet-829	61	21	plugs	plug	NOUN
admet-829	61	22	and	and	CCONJ
admet-829	61	23	all	all	DET
admet-829	61	24	particle	particle	NOUN
admet-829	61	25	size	size	NOUN
admet-829	61	26	fractions	fraction	NOUN
admet-829	61	27	1	1	NUM
admet-829	61	28	1	1	NUM
admet-829	61	29	1	1	NUM
admet-829	61	30	1	1	NUM
admet-829	61	31	p	p	NOUN
admet-829	61	32	t	t	X
admet-829	61	33	ij	ij	INTJ
admet-829	62	1	i	i	PRON
admet-829	62	2	j	j	PROPN
admet-829	62	3	nn	nn	INTJ
admet-829	62	4	y	y	PROPN
admet-829	62	5	y	y	PROPN
admet-829	62	6	(	(	PUNCT
admet-829	62	7	6	6	NUM
admet-829	62	8	)	)	PUNCT
admet-829	62	9	drug	drug	NOUN
admet-829	62	10	concentration	concentration	NOUN
admet-829	62	11	(	(	PUNCT
admet-829	62	12	mg	mg	NOUN
admet-829	62	13	/	/	SYM
admet-829	62	14	ml	ml	NOUN
admet-829	62	15	)	)	PUNCT
admet-829	62	16	in	in	ADP
admet-829	62	17	the	the	DET
admet-829	62	18	plasma	plasma	NOUN
admet-829	62	19	compartment	compartment	NOUN
admet-829	62	20	1	1	NUM
admet-829	62	21	t	t	NOUN
admet-829	62	22	central	central	NOUN
admet-829	63	1	d	d	X
admet-829	63	2	y	y	PROPN
admet-829	63	3	c	c	PROPN
admet-829	63	4	v	v	NOUN
admet-829	63	5	or	or	CCONJ
admet-829	63	6	1	1	NUM
admet-829	63	7	t	t	NOUN
admet-829	63	8	d	d	X
admet-829	63	9	b	b	PROPN
admet-829	63	10	y	y	PROPN
admet-829	63	11	v	v	NOUN
admet-829	63	12	m	m	PROPN
admet-829	63	13	(	(	PUNCT
admet-829	63	14	7	7	NUM
admet-829	63	15	)	)	PUNCT
admet-829	63	16	symbol	symbol	NOUN
admet-829	63	17	definition	definition	NOUN
admet-829	63	18	cl	cl	NOUN
admet-829	63	19	clearance	clearance	NOUN
admet-829	63	20	(	(	PUNCT
admet-829	63	21	ml	ml	NOUN
admet-829	63	22	/	/	SYM
admet-829	63	23	min	min	NOUN
admet-829	63	24	or	or	CCONJ
admet-829	63	25	ml	ml	NOUN
admet-829	63	26	/	/	SYM
admet-829	63	27	min	min	NOUN
admet-829	63	28	/	/	SYM
admet-829	63	29	mg	mg	NOUN
admet-829	63	30	)	)	PUNCT
admet-829	63	31	csj	csj	NOUN
admet-829	63	32	time	time	NOUN
admet-829	63	33	-	-	PUNCT
admet-829	63	34	dependent	dependent	ADJ
admet-829	63	35	drug	drug	NOUN
admet-829	63	36	solubility	solubility	NOUN
admet-829	63	37	(	(	PUNCT
admet-829	63	38	mg	mg	PROPN
admet-829	63	39	/	/	SYM
admet-829	63	40	ml	ml	NOUN
admet-829	63	41	)	)	PUNCT
admet-829	63	42	for	for	ADP
admet-829	63	43	drug	drug	NOUN
admet-829	63	44	in	in	ADP
admet-829	63	45	plug	plug	NOUN
admet-829	63	46	j	j	PROPN
admet-829	64	1	d	d	PROPN
admet-829	64	2	drug	drug	NOUN
admet-829	64	3	diffusion	diffusion	NOUN
admet-829	64	4	coefficient	coefficient	NOUN
admet-829	64	5	(	(	PUNCT
admet-829	64	6	cm2	cm2	NOUN
admet-829	64	7	/	/	SYM
admet-829	64	8	min	min	NOUN
admet-829	64	9	)	)	PUNCT
admet-829	64	10	fj	fj	PROPN
admet-829	64	11	bioavailability	bioavailability	NOUN
admet-829	64	12	factor	factor	NOUN
admet-829	64	13	for	for	ADP
admet-829	64	14	presystemic	presystemic	ADJ
admet-829	64	15	metabolism	metabolism	NOUN
admet-829	64	16	in	in	ADP
admet-829	64	17	plug	plug	NOUN
admet-829	64	18	j	j	PROPN
admet-829	64	19	hij	hij	PROPN
admet-829	64	20	time	time	NOUN
admet-829	64	21	-	-	PUNCT
admet-829	64	22	dependent	dependent	ADJ
admet-829	64	23	diffusion	diffusion	NOUN
admet-829	64	24	layer	layer	NOUN
admet-829	64	25	thickness	thickness	NOUN
admet-829	64	26	(	(	PUNCT
admet-829	64	27	cm	cm	NOUN
admet-829	64	28	)	)	PUNCT
admet-829	64	29	for	for	ADP
admet-829	64	30	particles	particle	NOUN
admet-829	64	31	in	in	ADP
admet-829	64	32	plug	plug	NOUN
admet-829	64	33	j	j	PROPN
admet-829	64	34	from	from	ADP
admet-829	64	35	particle	particle	NOUN
admet-829	64	36	size	size	NOUN
admet-829	64	37	fraction	fraction	NOUN
admet-829	64	38	i	i	PRON
admet-829	64	39	kaj	kaj	PROPN
admet-829	64	40	time	time	NOUN
admet-829	64	41	-	-	PUNCT
admet-829	64	42	dependent	dependent	ADJ
admet-829	64	43	absorption	absorption	NOUN
admet-829	64	44	rate	rate	NOUN
admet-829	64	45	constant	constant	ADJ
admet-829	64	46	for	for	ADP
admet-829	64	47	plug	plug	NOUN
admet-829	64	48	j	j	PROPN
admet-829	64	49	k12	k12	PROPN
admet-829	64	50	rate	rate	NOUN
admet-829	64	51	constant	constant	ADJ
admet-829	64	52	for	for	ADP
admet-829	64	53	transfer	transfer	NOUN
admet-829	64	54	of	of	ADP
admet-829	64	55	drug	drug	NOUN
admet-829	64	56	from	from	ADP
admet-829	64	57	the	the	DET
admet-829	64	58	plasma	plasma	NOUN
admet-829	64	59	to	to	ADP
admet-829	64	60	the	the	DET
admet-829	64	61	tissue	tissue	NOUN
admet-829	64	62	compartment	compartment	NOUN
admet-829	64	63	k21	k21	NOUN
admet-829	64	64	rate	rate	NOUN
admet-829	64	65	constant	constant	ADJ
admet-829	64	66	for	for	ADP
admet-829	64	67	transfer	transfer	NOUN
admet-829	64	68	of	of	ADP
admet-829	64	69	drug	drug	NOUN
admet-829	64	70	from	from	ADP
admet-829	64	71	the	the	DET
admet-829	64	72	tissue	tissue	NOUN
admet-829	64	73	to	to	ADP
admet-829	64	74	the	the	DET
admet-829	64	75	plasma	plasma	NOUN
admet-829	64	76	compartment	compartment	NOUN
admet-829	64	77	mb	mb	ADP
admet-829	64	78	body	body	NOUN
admet-829	64	79	mass	mass	NOUN
admet-829	64	80	when	when	SCONJ
admet-829	64	81	vd	vd	NOUN
admet-829	64	82	is	be	AUX
admet-829	64	83	given	give	VERB
admet-829	64	84	in	in	ADP
admet-829	64	85	units	unit	NOUN
admet-829	64	86	of	of	ADP
admet-829	64	87	volume	volume	NOUN
admet-829	64	88	per	per	ADP
admet-829	64	89	unit	unit	NOUN
admet-829	64	90	of	of	ADP
admet-829	64	91	body	body	NOUN
admet-829	64	92	mass	mass	NOUN
admet-829	65	1	n	n	DET
admet-829	65	2	number	number	NOUN
admet-829	65	3	of	of	ADP
admet-829	65	4	drug	drug	NOUN
admet-829	65	5	particle	particle	NOUN
admet-829	65	6	size	size	NOUN
admet-829	65	7	fractions	fraction	NOUN
admet-829	65	8	np	np	PRON
admet-829	65	9	number	number	NOUN
admet-829	65	10	of	of	ADP
admet-829	65	11	plugs	plug	NOUN
admet-829	65	12	ρ	ρ	PROPN
admet-829	65	13	drug	drug	NOUN
admet-829	65	14	density	density	NOUN
admet-829	65	15	(	(	PUNCT
admet-829	65	16	mg	mg	PROPN
admet-829	65	17	/	/	SYM
admet-829	65	18	cm3	cm3	NOUN
admet-829	65	19	)	)	PUNCT
admet-829	65	20	io	io	PROPN
admet-829	65	21	r	r	NOUN
admet-829	65	22	initial	initial	ADJ
admet-829	65	23	particle	particle	NOUN
admet-829	65	24	radius	radius	NOUN
admet-829	65	25	(	(	PUNCT
admet-829	65	26	cm	cm	NOUN
admet-829	65	27	)	)	PUNCT
admet-829	65	28	for	for	ADP
admet-829	65	29	particles	particle	NOUN
admet-829	65	30	in	in	ADP
admet-829	65	31	particle	particle	NOUN
admet-829	65	32	size	size	NOUN
admet-829	65	33	fraction	fraction	NOUN
admet-829	65	34	i	i	PRON
admet-829	65	35	t	t	VERB
admet-829	65	36	time	time	NOUN
admet-829	65	37	(	(	PUNCT
admet-829	65	38	min	min	NOUN
admet-829	65	39	)	)	PUNCT
admet-829	65	40	vd	vd	NOUN
admet-829	65	41	volume	volume	NOUN
admet-829	65	42	of	of	ADP
admet-829	65	43	distribution	distribution	NOUN
admet-829	65	44	(	(	PUNCT
admet-829	65	45	ml	ml	ADV
admet-829	65	46	or	or	CCONJ
admet-829	65	47	ml	ml	NOUN
admet-829	65	48	/	/	SYM
admet-829	65	49	mg	mg	NOUN
admet-829	65	50	)	)	PUNCT
admet-829	65	51	vj	vj	ADP
admet-829	65	52	time	time	NOUN
admet-829	65	53	-	-	PUNCT
admet-829	65	54	dependent	dependent	ADJ
admet-829	65	55	volume	volume	NOUN
admet-829	65	56	(	(	PUNCT
admet-829	65	57	ml	ml	NOUN
admet-829	65	58	)	)	PUNCT
admet-829	65	59	of	of	ADP
admet-829	65	60	plug	plug	VERB
admet-829	65	61	j	j	PROPN
admet-829	65	62	xoij	xoij	PROPN
admet-829	65	63	initial	initial	PROPN
admet-829	65	64	solid	solid	ADJ
admet-829	65	65	drug	drug	NOUN
admet-829	65	66	mass	mass	NOUN
admet-829	65	67	(	(	PUNCT
admet-829	65	68	mg	mg	PROPN
admet-829	65	69	)	)	PUNCT
admet-829	65	70	in	in	ADP
admet-829	65	71	the	the	DET
admet-829	65	72	gi	gi	NOUN
admet-829	65	73	tract	tract	NOUN
admet-829	65	74	in	in	ADP
admet-829	65	75	plug	plug	NOUN
admet-829	65	76	j	j	PROPN
admet-829	65	77	from	from	ADP
admet-829	65	78	particle	particle	NOUN
admet-829	65	79	size	size	NOUN
admet-829	65	80	fraction	fraction	NOUN
admet-829	65	81	i	i	PRON
admet-829	65	82	in	in	ADP
admet-829	65	83	keeping	keep	VERB
admet-829	65	84	with	with	ADP
admet-829	65	85	the	the	DET
admet-829	65	86	generally	generally	ADV
admet-829	65	87	accepted	accept	VERB
admet-829	65	88	view	view	NOUN
admet-829	65	89	that	that	SCONJ
admet-829	65	90	the	the	DET
admet-829	65	91	main	main	ADJ
admet-829	65	92	site	site	NOUN
admet-829	65	93	of	of	ADP
admet-829	65	94	drug	drug	NOUN
admet-829	65	95	absorption	absorption	NOUN
admet-829	65	96	is	be	AUX
admet-829	65	97	the	the	DET
admet-829	65	98	small	small	ADJ
admet-829	65	99	intestine	intestine	NOUN
admet-829	65	100	and	and	CCONJ
admet-829	65	101	not	not	PART
admet-829	65	102	the	the	DET
admet-829	65	103	stomach	stomach	NOUN
admet-829	65	104	[	[	X
admet-829	65	105	13	13	NUM
admet-829	65	106	]	]	PUNCT
admet-829	65	107	,	,	PUNCT
admet-829	65	108	kaj	kaj	PROPN
admet-829	65	109	was	be	AUX
admet-829	65	110	assumed	assume	VERB
admet-829	65	111	to	to	PART
admet-829	65	112	be	be	AUX
admet-829	65	113	zero	zero	NUM
admet-829	65	114	while	while	SCONJ
admet-829	65	115	plug	plug	NOUN
admet-829	65	116	j	j	PROPN
admet-829	65	117	was	be	AUX
admet-829	65	118	in	in	ADP
admet-829	65	119	the	the	DET
admet-829	65	120	stomach	stomach	NOUN
admet-829	65	121	.	.	PUNCT
admet-829	66	1	the	the	DET
admet-829	66	2	number	number	NOUN
admet-829	66	3	of	of	ADP
admet-829	66	4	plugs	plug	NOUN
admet-829	66	5	exiting	exit	VERB
admet-829	66	6	the	the	DET
admet-829	66	7	stomach	stomach	NOUN
admet-829	66	8	could	could	AUX
admet-829	66	9	be	be	AUX
admet-829	66	10	any	any	DET
admet-829	66	11	number	number	NOUN
admet-829	66	12	np	np	NOUN
admet-829	66	13	,	,	PUNCT
admet-829	66	14	and	and	CCONJ
admet-829	66	15	the	the	DET
admet-829	66	16	volume	volume	NOUN
admet-829	66	17	of	of	ADP
admet-829	66	18	each	each	DET
admet-829	66	19	plug	plug	NOUN
admet-829	66	20	vj	vj	NOUN
admet-829	66	21	could	could	AUX
admet-829	66	22	be	be	AUX
admet-829	66	23	any	any	DET
admet-829	66	24	fraction	fraction	NOUN
admet-829	66	25	of	of	ADP
admet-829	66	26	the	the	DET
admet-829	66	27	total	total	ADJ
admet-829	66	28	volume	volume	NOUN
admet-829	66	29	containing	contain	VERB
admet-829	66	30	any	any	DET
admet-829	66	31	fraction	fraction	NOUN
admet-829	66	32	of	of	ADP
admet-829	66	33	the	the	DET
admet-829	66	34	total	total	ADJ
admet-829	66	35	dose	dose	NOUN
admet-829	66	36	.	.	PUNCT
admet-829	67	1	for	for	ADP
admet-829	67	2	simplicity	simplicity	NOUN
admet-829	67	3	,	,	PUNCT
admet-829	67	4	each	each	DET
admet-829	67	5	vj	vj	NOUN
admet-829	67	6	was	be	AUX
admet-829	67	7	equal	equal	ADJ
admet-829	67	8	to	to	ADP
admet-829	67	9	240	240	NUM
admet-829	67	10	ml	ml	ADP
admet-829	67	11	divided	divide	VERB
admet-829	67	12	by	by	ADP
admet-829	67	13	np	np	INTJ
admet-829	67	14	(	(	PUNCT
admet-829	67	15	240	240	NUM
admet-829	67	16	ml/3	ml/3	NOUN
admet-829	67	17	=	=	SYM
admet-829	67	18	80	80	NUM
admet-829	67	19	ml	ml	NOUN
admet-829	67	20	)	)	PUNCT
admet-829	67	21	.	.	PUNCT
admet-829	68	1	admet	admet	PROPN
admet-829	68	2	&	&	CCONJ
admet-829	68	3	dmpk	dmpk	PROPN
admet-829	68	4	8(3	8(3	NUM
admet-829	68	5	)	)	PUNCT
admet-829	68	6	(	(	PUNCT
admet-829	68	7	2020	2020	NUM
admet-829	68	8	)	)	PUNCT
admet-829	68	9	314	314	NUM
admet-829	68	10	-	-	SYM
admet-829	68	11	324	324	NUM
admet-829	68	12	mechanistic	mechanistic	ADJ
admet-829	68	13	modeling	modeling	NOUN
admet-829	68	14	of	of	ADP
admet-829	68	15	gastrointestinal	gastrointestinal	ADJ
admet-829	68	16	motility	motility	NOUN
admet-829	68	17	doi	doi	NOUN
admet-829	68	18	:	:	PUNCT
admet-829	68	19	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	NOUN
admet-829	68	20	317	317	NUM
admet-829	68	21	table	table	NOUN
admet-829	68	22	2	2	NUM
admet-829	68	23	.	.	PUNCT
admet-829	69	1	parameters	parameter	NOUN
admet-829	69	2	used	use	VERB
admet-829	69	3	for	for	ADP
admet-829	69	4	simulations	simulation	NOUN
admet-829	69	5	.	.	PUNCT
admet-829	70	1	to	to	PART
admet-829	70	2	simulate	simulate	VERB
admet-829	70	3	gastric	gastric	ADJ
admet-829	70	4	emptying	emptying	NOUN
admet-829	70	5	,	,	PUNCT
admet-829	70	6	kaj	kaj	PROPN
admet-829	70	7	was	be	AUX
admet-829	70	8	transitioned	transition	VERB
admet-829	70	9	from	from	ADP
admet-829	70	10	its	its	PRON
admet-829	70	11	value	value	NOUN
admet-829	70	12	of	of	ADP
admet-829	70	13	zero	zero	NUM
admet-829	70	14	in	in	ADP
admet-829	70	15	the	the	DET
admet-829	70	16	stomach	stomach	NOUN
admet-829	70	17	to	to	ADP
admet-829	70	18	its	its	PRON
admet-829	70	19	value	value	NOUN
admet-829	70	20	of	of	ADP
admet-829	70	21	0.07	0.07	NUM
admet-829	70	22	min-1	min-1	NOUN
admet-829	70	23	in	in	ADP
admet-829	70	24	the	the	DET
admet-829	70	25	duodenum	duodenum	NOUN
admet-829	70	26	.	.	PUNCT
admet-829	71	1	the	the	DET
admet-829	71	2	transition	transition	NOUN
admet-829	71	3	time	time	NOUN
admet-829	71	4	was	be	AUX
admet-829	71	5	assumed	assume	VERB
admet-829	71	6	to	to	PART
admet-829	71	7	be	be	AUX
admet-829	71	8	1	1	NUM
admet-829	71	9	minute	minute	NOUN
admet-829	71	10	.	.	PUNCT
admet-829	71	11	table	table	NOUN
admet-829	71	12	3	3	NUM
admet-829	71	13	shows	show	VERB
admet-829	71	14	the	the	DET
admet-829	71	15	equation	equation	NOUN
admet-829	71	16	and	and	CCONJ
admet-829	71	17	parameters	parameter	NOUN
admet-829	71	18	used	use	VERB
admet-829	71	19	to	to	PART
admet-829	71	20	simulate	simulate	VERB
admet-829	71	21	a	a	DET
admet-829	71	22	smooth	smooth	ADJ
admet-829	71	23	sigmoidal	sigmoidal	NOUN
admet-829	71	24	transition	transition	NOUN
admet-829	71	25	for	for	ADP
admet-829	71	26	the	the	DET
admet-829	71	27	value	value	NOUN
admet-829	71	28	of	of	ADP
admet-829	71	29	kaj	kaj	PROPN
admet-829	71	30	,	,	PUNCT
admet-829	71	31	but	but	CCONJ
admet-829	71	32	any	any	DET
admet-829	71	33	appropriate	appropriate	ADJ
admet-829	71	34	function	function	NOUN
admet-829	71	35	could	could	AUX
admet-829	71	36	be	be	AUX
admet-829	71	37	used	use	VERB
admet-829	71	38	to	to	PART
admet-829	71	39	accomplish	accomplish	VERB
admet-829	71	40	the	the	DET
admet-829	71	41	transition	transition	NOUN
admet-829	71	42	.	.	PUNCT
admet-829	72	1	a	a	DET
admet-829	72	2	simulation	simulation	NOUN
admet-829	72	3	using	use	VERB
admet-829	72	4	immediate	immediate	ADJ
admet-829	72	5	changes	change	NOUN
admet-829	72	6	for	for	ADP
admet-829	72	7	kaj	kaj	PROPN
admet-829	72	8	instead	instead	ADV
admet-829	72	9	of	of	ADP
admet-829	72	10	smooth	smooth	ADJ
admet-829	72	11	transitions	transition	NOUN
admet-829	72	12	was	be	AUX
admet-829	72	13	essentially	essentially	ADV
admet-829	72	14	the	the	DET
admet-829	72	15	same	same	ADJ
admet-829	72	16	as	as	ADP
admet-829	72	17	the	the	DET
admet-829	72	18	original	original	ADJ
admet-829	72	19	simulation	simulation	NOUN
admet-829	72	20	.	.	PUNCT
admet-829	73	1	however	however	ADV
admet-829	73	2	,	,	PUNCT
admet-829	73	3	smooth	smooth	ADJ
admet-829	73	4	transitions	transition	NOUN
admet-829	73	5	are	be	AUX
admet-829	73	6	recommended	recommend	VERB
admet-829	73	7	as	as	SCONJ
admet-829	73	8	abrupt	abrupt	ADJ
admet-829	73	9	changes	change	NOUN
admet-829	73	10	can	can	AUX
admet-829	73	11	lead	lead	VERB
admet-829	73	12	to	to	ADP
admet-829	73	13	instabilities	instability	NOUN
admet-829	73	14	in	in	ADP
admet-829	73	15	the	the	DET
admet-829	73	16	numerical	numerical	ADJ
admet-829	73	17	method	method	NOUN
admet-829	73	18	.	.	PUNCT
admet-829	74	1	table	table	NOUN
admet-829	74	2	3	3	NUM
admet-829	74	3	.	.	X
admet-829	74	4	equation	equation	NOUN
admet-829	74	5	and	and	CCONJ
admet-829	74	6	symbol	symbol	NOUN
admet-829	74	7	definitions	definition	NOUN
admet-829	74	8	used	use	VERB
admet-829	74	9	to	to	PART
admet-829	74	10	simulate	simulate	VERB
admet-829	74	11	a	a	DET
admet-829	74	12	smooth	smooth	ADJ
admet-829	74	13	transition	transition	NOUN
admet-829	74	14	for	for	SCONJ
admet-829	74	15	the	the	DET
admet-829	74	16	absorption	absorption	NOUN
admet-829	74	17	rate	rate	NOUN
admet-829	74	18	constant	constant	ADJ
admet-829	74	19	.	.	PUNCT
admet-829	75	1	quantity	quantity	NOUN
admet-829	75	2	being	be	AUX
admet-829	75	3	tracked	track	VERB
admet-829	75	4	equation	equation	NOUN
admet-829	75	5	time	time	NOUN
admet-829	75	6	dependent	dependent	ADJ
admet-829	75	7	absorption	absorption	NOUN
admet-829	75	8	rate	rate	NOUN
admet-829	75	9	constant	constant	ADJ
admet-829	75	10	for	for	ADP
admet-829	75	11	plug	plug	NOUN
admet-829	75	12	j	j	PROPN
admet-829	75	13	2	2	NUM
admet-829	75	14	2	2	NUM
admet-829	75	15	a	a	DET
admet-829	75	16	si	si	NOUN
admet-829	75	17	a	a	DET
admet-829	75	18	stj	stj	NOUN
admet-829	76	1	j	j	PROPN
admet-829	77	1	j	j	PROPN
admet-829	77	2	j	j	PROPN
admet-829	78	1	j	j	PROPN
admet-829	78	2	j	j	PROPN
admet-829	78	3	j	j	PROPN
admet-829	78	4	j	j	PROPN
admet-829	78	5	a	a	DET
admet-829	78	6	si	si	X
admet-829	78	7	a	a	DET
admet-829	78	8	stj	stj	NOUN
admet-829	78	9	j	j	PROPN
admet-829	78	10	k	k	PROPN
admet-829	78	11	ka	ka	PROPN
admet-829	79	1	si	si	PROPN
admet-829	79	2	a	a	DET
admet-829	79	3	st	st	PROPN
admet-829	79	4	a	a	DET
admet-829	79	5	si	si	PROPN
admet-829	79	6	a	a	DET
admet-829	79	7	st	st	PROPN
admet-829	79	8	a	a	DET
admet-829	79	9	a	a	DET
admet-829	79	10	st	st	PROPN
admet-829	79	11	k	k	PROPN
admet-829	79	12	k	k	PROPN
admet-829	80	1	[	[	PUNCT
admet-829	80	2	(	(	PUNCT
admet-829	80	3	)	)	PUNCT
admet-829	80	4	]	]	X
admet-829	80	5	cos	cos	PROPN
admet-829	80	6	t	t	PROPN
admet-829	80	7	t	t	PROPN
admet-829	80	8	tk	tk	PROPN
admet-829	80	9	k	k	PROPN
admet-829	80	10	k	k	PROPN
admet-829	80	11	k	k	PROPN
admet-829	80	12	k	k	PROPN
admet-829	80	13	k	k	PROPN
admet-829	80	14	t	t	PROPN
admet-829	80	15	t	t	PROPN
admet-829	80	16	(	(	PUNCT
admet-829	80	17	8)	8)	NUM
admet-829	80	18	symbol	symbol	NOUN
admet-829	80	19	definition	definition	NOUN
admet-829	80	20	kajsi	kajsi	VERB
admet-829	80	21	absorption	absorption	NOUN
admet-829	80	22	rate	rate	NOUN
admet-829	80	23	constant	constant	ADJ
admet-829	80	24	for	for	SCONJ
admet-829	80	25	plug	plug	NOUN
admet-829	80	26	j	j	PROPN
admet-829	80	27	in	in	ADP
admet-829	80	28	the	the	DET
admet-829	80	29	small	small	ADJ
admet-829	80	30	intestine	intestine	NOUN
admet-829	80	31	kajst	kajst	ADJ
admet-829	80	32	absorption	absorption	NOUN
admet-829	80	33	rate	rate	NOUN
admet-829	80	34	constant	constant	ADJ
admet-829	80	35	for	for	ADP
admet-829	80	36	plug	plug	NOUN
admet-829	80	37	j	j	PROPN
admet-829	80	38	in	in	ADP
admet-829	80	39	the	the	DET
admet-829	80	40	stomach	stomach	NOUN
admet-829	80	41	tkajsi	tkajsi	NOUN
admet-829	80	42	time	time	NOUN
admet-829	80	43	at	at	ADP
admet-829	80	44	which	which	PRON
admet-829	80	45	kaj	kaj	PROPN
admet-829	80	46	completes	complete	VERB
admet-829	80	47	its	its	PRON
admet-829	80	48	transition	transition	NOUN
admet-829	80	49	to	to	PART
admet-829	80	50	kajsi	kajsi	VERB
admet-829	80	51	from	from	ADP
admet-829	80	52	kajst	kajst	ADJ
admet-829	80	53	tkajst	tkajst	ADJ
admet-829	80	54	time	time	NOUN
admet-829	80	55	at	at	ADP
admet-829	80	56	which	which	PRON
admet-829	80	57	kaj	kaj	PROPN
admet-829	80	58	begins	begin	VERB
admet-829	80	59	its	its	PRON
admet-829	80	60	transition	transition	NOUN
admet-829	80	61	from	from	ADP
admet-829	80	62	kajst	kajst	ADJ
admet-829	80	63	to	to	PART
admet-829	80	64	kajsi	kajsi	VERB
admet-829	80	65	the	the	DET
admet-829	80	66	function	function	NOUN
admet-829	80	67	described	describe	VERB
admet-829	80	68	by	by	ADP
admet-829	80	69	equation	equation	NOUN
admet-829	80	70	8	8	NUM
admet-829	80	71	in	in	ADP
admet-829	80	72	table	table	NOUN
admet-829	80	73	3	3	NUM
admet-829	80	74	is	be	AUX
admet-829	80	75	bounded	bound	VERB
admet-829	80	76	by	by	ADP
admet-829	80	77	two	two	NUM
admet-829	80	78	pair	pair	NOUN
admet-829	80	79	of	of	ADP
admet-829	80	80	points	point	NOUN
admet-829	80	81	:	:	PUNCT
admet-829	80	82	(	(	PUNCT
admet-829	80	83	tkajst	tkajst	ADJ
admet-829	80	84	,	,	PUNCT
admet-829	80	85	kajst	kajst	ADJ
admet-829	80	86	)	)	PUNCT
admet-829	80	87	and	and	CCONJ
admet-829	80	88	(	(	PUNCT
admet-829	80	89	tkajsi	tkajsi	NOUN
admet-829	80	90	,	,	PUNCT
admet-829	80	91	kajsi	kajsi	PROPN
admet-829	80	92	)	)	PUNCT
admet-829	80	93	.	.	PUNCT
admet-829	81	1	the	the	DET
admet-829	81	2	number	number	NOUN
admet-829	81	3	of	of	ADP
admet-829	81	4	transitions	transition	NOUN
admet-829	81	5	can	can	AUX
admet-829	81	6	be	be	AUX
admet-829	81	7	increased	increase	VERB
admet-829	81	8	by	by	ADP
admet-829	81	9	using	use	VERB
admet-829	81	10	equation	equation	NOUN
admet-829	81	11	8	8	NUM
admet-829	81	12	and	and	CCONJ
admet-829	81	13	common	common	ADJ
admet-829	81	14	points	point	NOUN
admet-829	81	15	as	as	ADP
admet-829	81	16	the	the	DET
admet-829	81	17	start	start	NOUN
admet-829	81	18	and	and	CCONJ
admet-829	81	19	end	end	VERB
admet-829	81	20	points	point	NOUN
admet-829	81	21	of	of	ADP
admet-829	81	22	transitions	transition	NOUN
admet-829	81	23	.	.	PUNCT
admet-829	82	1	the	the	DET
admet-829	82	2	time	time	NOUN
admet-829	82	3	course	course	NOUN
admet-829	82	4	of	of	ADP
admet-829	82	5	transitions	transition	NOUN
admet-829	82	6	taking	take	VERB
admet-829	82	7	place	place	NOUN
admet-829	82	8	within	within	ADP
admet-829	82	9	a	a	DET
admet-829	82	10	given	give	VERB
admet-829	82	11	plug	plug	NOUN
admet-829	82	12	can	can	AUX
admet-829	82	13	be	be	AUX
admet-829	82	14	made	make	VERB
admet-829	82	15	to	to	PART
admet-829	82	16	be	be	AUX
admet-829	82	17	completely	completely	ADV
admet-829	82	18	independent	independent	ADJ
admet-829	82	19	of	of	ADP
admet-829	82	20	that	that	PRON
admet-829	82	21	in	in	ADP
admet-829	82	22	any	any	DET
admet-829	82	23	other	other	ADJ
admet-829	82	24	plug	plug	NOUN
admet-829	82	25	.	.	PUNCT
admet-829	83	1	if	if	SCONJ
admet-829	83	2	the	the	DET
admet-829	83	3	initial	initial	ADJ
admet-829	83	4	conditions	condition	NOUN
admet-829	83	5	and	and	CCONJ
admet-829	83	6	transitions	transition	NOUN
admet-829	83	7	that	that	PRON
admet-829	83	8	define	define	VERB
admet-829	83	9	each	each	DET
admet-829	83	10	plug	plug	NOUN
admet-829	83	11	are	be	AUX
admet-829	83	12	exactly	exactly	ADV
admet-829	83	13	the	the	DET
admet-829	83	14	same	same	ADJ
admet-829	83	15	,	,	PUNCT
admet-829	83	16	then	then	ADV
admet-829	83	17	the	the	DET
admet-829	83	18	simulation	simulation	NOUN
admet-829	83	19	would	would	AUX
admet-829	83	20	be	be	AUX
admet-829	83	21	equivalent	equivalent	ADJ
admet-829	83	22	to	to	ADP
admet-829	83	23	a	a	DET
admet-829	83	24	single	single	ADJ
admet-829	83	25	plug	plug	NOUN
admet-829	83	26	of	of	ADP
admet-829	83	27	the	the	DET
admet-829	83	28	equivalent	equivalent	ADJ
admet-829	83	29	total	total	NOUN
admet-829	83	30	dose	dose	NOUN
admet-829	83	31	and	and	CCONJ
admet-829	83	32	volume	volume	NOUN
admet-829	83	33	.	.	PUNCT
admet-829	84	1	modeled	model	VERB
admet-829	84	2	as	as	ADP
admet-829	84	3	a	a	DET
admet-829	84	4	series	series	NOUN
admet-829	84	5	of	of	ADP
admet-829	84	6	discrete	discrete	ADJ
admet-829	84	7	fluid	fluid	ADJ
admet-829	84	8	plugs	plug	NOUN
admet-829	84	9	exiting	exit	VERB
admet-829	84	10	the	the	DET
admet-829	84	11	stomach	stomach	NOUN
admet-829	84	12	,	,	PUNCT
admet-829	84	13	each	each	PRON
admet-829	84	14	containing	contain	VERB
admet-829	84	15	drug	drug	NOUN
admet-829	84	16	particles	particle	NOUN
admet-829	84	17	in	in	ADP
admet-829	84	18	the	the	DET
admet-829	84	19	process	process	NOUN
admet-829	84	20	of	of	ADP
admet-829	84	21	dissolving	dissolving	NOUN
admet-829	84	22	,	,	PUNCT
admet-829	84	23	the	the	DET
admet-829	84	24	effect	effect	NOUN
admet-829	84	25	of	of	ADP
admet-829	84	26	gastric	gastric	ADJ
admet-829	84	27	emptying	empty	VERB
admet-829	84	28	and	and	CCONJ
admet-829	84	29	drug	drug	NOUN
admet-829	84	30	particle	particle	NOUN
admet-829	84	31	size	size	NOUN
admet-829	84	32	on	on	ADP
admet-829	84	33	drug	drug	NOUN
admet-829	84	34	pharmacokinetics	pharmacokinetic	NOUN
admet-829	84	35	was	be	AUX
admet-829	84	36	simulated	simulate	VERB
admet-829	84	37	for	for	ADP
admet-829	84	38	three	three	NUM
admet-829	84	39	evenly	evenly	ADV
admet-829	84	40	-	-	PUNCT
admet-829	84	41	spaced	space	VERB
admet-829	84	42	plugs	plug	NOUN
admet-829	84	43	.	.	PUNCT
admet-829	85	1	the	the	DET
admet-829	85	2	total	total	ADJ
admet-829	85	3	dose	dose	NOUN
admet-829	85	4	and	and	CCONJ
admet-829	85	5	fluid	fluid	ADJ
admet-829	85	6	volume	volume	NOUN
admet-829	85	7	were	be	AUX
admet-829	85	8	held	hold	VERB
admet-829	85	9	constant	constant	ADJ
admet-829	85	10	,	,	PUNCT
admet-829	85	11	but	but	CCONJ
admet-829	85	12	the	the	DET
admet-829	85	13	drug	drug	NOUN
admet-829	85	14	particle	particle	NOUN
admet-829	85	15	size	size	NOUN
admet-829	85	16	and	and	CCONJ
admet-829	85	17	dose	dose	NOUN
admet-829	85	18	in	in	ADP
admet-829	85	19	individual	individual	ADJ
admet-829	85	20	plugs	plug	NOUN
admet-829	85	21	were	be	AUX
admet-829	85	22	changed	change	VERB
admet-829	85	23	between	between	ADP
admet-829	85	24	simulations	simulation	NOUN
admet-829	85	25	as	as	SCONJ
admet-829	85	26	shown	show	VERB
admet-829	85	27	in	in	ADP
admet-829	85	28	table	table	NOUN
admet-829	85	29	4	4	NUM
admet-829	85	30	.	.	PUNCT
admet-829	86	1	in	in	ADP
admet-829	86	2	each	each	DET
admet-829	86	3	simulation	simulation	NOUN
admet-829	86	4	,	,	PUNCT
admet-829	86	5	the	the	DET
admet-829	86	6	first	first	ADJ
admet-829	86	7	plug	plug	NOUN
admet-829	86	8	began	begin	VERB
admet-829	86	9	to	to	PART
admet-829	86	10	transition	transition	VERB
admet-829	86	11	from	from	ADP
admet-829	86	12	the	the	DET
admet-829	86	13	stomach	stomach	NOUN
admet-829	86	14	to	to	ADP
admet-829	86	15	the	the	DET
admet-829	86	16	small	small	ADJ
admet-829	86	17	intestine	intestine	NOUN
admet-829	86	18	immediately	immediately	ADV
admet-829	86	19	,	,	PUNCT
admet-829	86	20	the	the	DET
admet-829	86	21	second	second	ADJ
admet-829	86	22	beginning	beginning	NOUN
admet-829	86	23	at	at	ADP
admet-829	86	24	15	15	NUM
admet-829	86	25	minutes	minute	NOUN
admet-829	86	26	,	,	PUNCT
admet-829	86	27	and	and	CCONJ
admet-829	86	28	the	the	DET
admet-829	86	29	third	third	ADJ
admet-829	86	30	beginning	beginning	NOUN
admet-829	86	31	at	at	ADP
admet-829	86	32	30	30	NUM
admet-829	86	33	minutes	minute	NOUN
admet-829	86	34	.	.	PUNCT
admet-829	87	1	table	table	NOUN
admet-829	87	2	4	4	NUM
admet-829	87	3	.	.	X
admet-829	87	4	plug	plug	VERB
admet-829	87	5	specific	specific	ADJ
admet-829	87	6	parameters	parameter	NOUN
admet-829	87	7	used	use	VERB
admet-829	87	8	in	in	ADP
admet-829	87	9	figure	figure	NOUN
admet-829	87	10	2	2	NUM
admet-829	87	11	-	-	SYM
admet-829	87	12	4	4	NUM
admet-829	87	13	simulations	simulation	NOUN
admet-829	87	14	.	.	PUNCT
admet-829	88	1	figure	figure	NOUN
admet-829	88	2	plug	plug	NOUN
admet-829	88	3	#	#	NOUN
admet-829	88	4	gastric	gastric	ADJ
admet-829	88	5	emptying	empty	VERB
admet-829	88	6	onset	onset	VERB
admet-829	88	7	time	time	NOUN
admet-829	88	8	(	(	PUNCT
admet-829	88	9	min	min	NOUN
admet-829	88	10	)	)	PUNCT
admet-829	88	11	dose	dose	NOUN
admet-829	88	12	in	in	ADP
admet-829	88	13	plug	plug	NOUN
admet-829	88	14	(	(	PUNCT
admet-829	88	15	mg	mg	NOUN
admet-829	88	16	)	)	PUNCT
admet-829	88	17	drug	drug	NOUN
admet-829	88	18	particle	particle	NOUN
admet-829	88	19	size	size	NOUN
admet-829	88	20	(	(	PUNCT
admet-829	88	21	µm	µm	NOUN
admet-829	88	22	)	)	PUNCT
admet-829	88	23	2	2	NUM
admet-829	88	24	1	1	NUM
admet-829	88	25	0	0	NUM
admet-829	88	26	(	(	PUNCT
admet-829	88	27	red	red	PROPN
admet-829	88	28	)	)	PUNCT
admet-829	88	29	0.8	0.8	NUM
admet-829	88	30	1	1	NUM
admet-829	88	31	2	2	NUM
admet-829	88	32	15	15	NUM
admet-829	88	33	(	(	PUNCT
admet-829	88	34	blue	blue	ADJ
admet-829	88	35	)	)	PUNCT
admet-829	88	36	0.8	0.8	NUM
admet-829	88	37	1	1	NUM
admet-829	88	38	3	3	NUM
admet-829	88	39	30	30	NUM
admet-829	88	40	(	(	PUNCT
admet-829	88	41	green	green	NOUN
admet-829	88	42	)	)	PUNCT
admet-829	88	43	0.8	0.8	NUM
admet-829	88	44	1	1	NUM
admet-829	88	45	3	3	NUM
admet-829	88	46	1	1	NUM
admet-829	88	47	0	0	NUM
admet-829	88	48	(	(	PUNCT
admet-829	88	49	red	red	PROPN
admet-829	88	50	)	)	PUNCT
admet-829	88	51	0.8	0.8	NUM
admet-829	88	52	10	10	NUM
admet-829	88	53	2	2	NUM
admet-829	88	54	15	15	NUM
admet-829	88	55	(	(	PUNCT
admet-829	88	56	blue	blue	ADJ
admet-829	88	57	)	)	PUNCT
admet-829	88	58	0.8	0.8	NUM
admet-829	88	59	10	10	NUM
admet-829	88	60	3	3	NUM
admet-829	88	61	30	30	NUM
admet-829	88	62	(	(	PUNCT
admet-829	88	63	green	green	NOUN
admet-829	88	64	)	)	PUNCT
admet-829	88	65	0.8	0.8	NUM
admet-829	88	66	10	10	NUM
admet-829	88	67	4	4	NUM
admet-829	88	68	1	1	NUM
admet-829	88	69	0	0	NUM
admet-829	88	70	(	(	PUNCT
admet-829	88	71	red	red	ADJ
admet-829	88	72	)	)	PUNCT
admet-829	88	73	0	0	NUM
admet-829	88	74	1	1	NUM
admet-829	88	75	2	2	NUM
admet-829	88	76	15	15	NUM
admet-829	88	77	(	(	PUNCT
admet-829	88	78	blue	blue	ADJ
admet-829	88	79	)	)	PUNCT
admet-829	88	80	1.2	1.2	NUM
admet-829	88	81	1	1	NUM
admet-829	88	82	3	3	NUM
admet-829	88	83	30	30	NUM
admet-829	88	84	(	(	PUNCT
admet-829	88	85	green	green	NOUN
admet-829	88	86	)	)	PUNCT
admet-829	88	87	1.2	1.2	NUM
admet-829	88	88	1	1	NUM
admet-829	88	89	parameter	parameter	NOUN
admet-829	88	90	value	value	NOUN
admet-829	88	91	drug	drug	NOUN
admet-829	88	92	solubility	solubility	NOUN
admet-829	88	93	(	(	PUNCT
admet-829	88	94	mg	mg	PROPN
admet-829	88	95	/	/	SYM
admet-829	88	96	ml	ml	NOUN
admet-829	88	97	)	)	PUNCT
admet-829	89	1	0.01	0.01	NUM
admet-829	89	2	total	total	NOUN
admet-829	89	3	dissolution	dissolution	NOUN
admet-829	89	4	volume	volume	NOUN
admet-829	89	5	(	(	PUNCT
admet-829	89	6	ml	ml	NOUN
admet-829	89	7	)	)	PUNCT
admet-829	89	8	240	240	NUM
admet-829	89	9	drug	drug	NOUN
admet-829	89	10	density	density	NOUN
admet-829	89	11	(	(	PUNCT
admet-829	89	12	g	g	NOUN
admet-829	89	13	/	/	SYM
admet-829	89	14	cm	cm	NOUN
admet-829	89	15	3	3	NUM
admet-829	89	16	)	)	PUNCT
admet-829	89	17	1.3	1.3	NUM
admet-829	89	18	diffusion	diffusion	NOUN
admet-829	89	19	coefficient	coefficient	NOUN
admet-829	89	20	(	(	PUNCT
admet-829	89	21	cm	cm	NOUN
admet-829	89	22	2	2	NUM
admet-829	89	23	/min	/min	SYM
admet-829	89	24	)	)	PUNCT
admet-829	89	25	0.0003	0.0003	NUM
admet-829	89	26	body	body	NOUN
admet-829	89	27	mass	mass	NOUN
admet-829	89	28	(	(	PUNCT
admet-829	89	29	kg	kg	NOUN
admet-829	89	30	)	)	PUNCT
admet-829	89	31	70	70	NUM
admet-829	89	32	bioavailability	bioavailability	NOUN
admet-829	89	33	factor	factor	NOUN
admet-829	89	34	0.5	0.5	NUM
admet-829	89	35	clearance	clearance	NOUN
admet-829	89	36	(	(	PUNCT
admet-829	89	37	ml	ml	NOUN
admet-829	89	38	/	/	SYM
admet-829	89	39	min	min	NOUN
admet-829	89	40	/	/	SYM
admet-829	89	41	kg	kg	NOUN
admet-829	89	42	)	)	PUNCT
admet-829	89	43	4	4	NUM
admet-829	89	44	volume	volume	NOUN
admet-829	89	45	of	of	ADP
admet-829	89	46	distribution	distribution	NOUN
admet-829	89	47	(	(	PUNCT
admet-829	89	48	ml	ml	NOUN
admet-829	89	49	/	/	SYM
admet-829	89	50	kg	kg	NOUN
admet-829	89	51	)	)	PUNCT
admet-829	89	52	600	600	NUM
admet-829	89	53	k12	k12	NOUN
admet-829	89	54	(	(	PUNCT
admet-829	89	55	min	min	NOUN
admet-829	89	56	-1	-1	ADJ
admet-829	89	57	)	)	PUNCT
admet-829	89	58	0.03	0.03	NUM
admet-829	89	59	k21	k21	NOUN
admet-829	89	60	(	(	PUNCT
admet-829	89	61	min	min	NOUN
admet-829	89	62	-1	-1	PROPN
admet-829	89	63	)	)	PUNCT
admet-829	89	64	0.01	0.01	NUM
admet-829	89	65	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	89	66	kevin	kevin	PROPN
admet-829	89	67	c.	c.	PROPN
admet-829	89	68	johnson	johnson	PROPN
admet-829	89	69	admet	admet	PROPN
admet-829	89	70	&	&	CCONJ
admet-829	89	71	dmpk	dmpk	PROPN
admet-829	89	72	8(3	8(3	NUM
admet-829	89	73	)	)	PUNCT
admet-829	89	74	(	(	PUNCT
admet-829	89	75	2020	2020	NUM
admet-829	89	76	)	)	PUNCT
admet-829	89	77	314	314	NUM
admet-829	89	78	-	-	SYM
admet-829	89	79	324	324	NUM
admet-829	89	80	318	318	NUM
admet-829	89	81	results	result	NOUN
admet-829	89	82	and	and	CCONJ
admet-829	89	83	discussion	discussion	NOUN
admet-829	89	84	figures	figure	VERB
admet-829	89	85	2	2	NUM
admet-829	89	86	-	-	SYM
admet-829	89	87	4	4	NUM
admet-829	89	88	show	show	VERB
admet-829	89	89	a	a	DET
admet-829	89	90	series	series	NOUN
admet-829	89	91	of	of	ADP
admet-829	89	92	simulations	simulation	NOUN
admet-829	89	93	using	use	VERB
admet-829	89	94	the	the	DET
admet-829	89	95	multiple	multiple	ADJ
admet-829	89	96	moving	move	VERB
admet-829	89	97	plug	plug	NOUN
admet-829	89	98	model	model	NOUN
admet-829	89	99	.	.	PUNCT
admet-829	90	1	the	the	DET
admet-829	90	2	main	main	ADJ
admet-829	90	3	goal	goal	NOUN
admet-829	90	4	was	be	AUX
admet-829	90	5	to	to	PART
admet-829	90	6	provide	provide	VERB
admet-829	90	7	a	a	DET
admet-829	90	8	visual	visual	ADJ
admet-829	90	9	and	and	CCONJ
admet-829	90	10	conceptual	conceptual	ADJ
admet-829	90	11	understanding	understanding	NOUN
admet-829	90	12	of	of	ADP
admet-829	90	13	the	the	DET
admet-829	90	14	model	model	NOUN
admet-829	90	15	and	and	CCONJ
admet-829	90	16	its	its	PRON
admet-829	90	17	capabilities	capability	NOUN
admet-829	90	18	within	within	ADP
admet-829	90	19	a	a	DET
admet-829	90	20	limited	limited	ADJ
admet-829	90	21	number	number	NOUN
admet-829	90	22	of	of	ADP
admet-829	90	23	simulations	simulation	NOUN
admet-829	90	24	.	.	PUNCT
admet-829	91	1	with	with	ADP
admet-829	91	2	this	this	PRON
admet-829	91	3	in	in	ADP
admet-829	91	4	mind	mind	NOUN
admet-829	91	5	,	,	PUNCT
admet-829	91	6	the	the	DET
admet-829	91	7	number	number	NOUN
admet-829	91	8	of	of	ADP
admet-829	91	9	plugs	plug	NOUN
admet-829	91	10	(	(	PUNCT
admet-829	91	11	3	3	NUM
admet-829	91	12	)	)	PUNCT
admet-829	91	13	,	,	PUNCT
admet-829	91	14	their	their	PRON
admet-829	91	15	individual	individual	ADJ
admet-829	91	16	volumes	volume	NOUN
admet-829	91	17	(	(	PUNCT
admet-829	91	18	80	80	NUM
admet-829	91	19	ml	ml	NOUN
admet-829	91	20	)	)	PUNCT
admet-829	91	21	,	,	PUNCT
admet-829	91	22	and	and	CCONJ
admet-829	91	23	the	the	DET
admet-829	91	24	timing	timing	NOUN
admet-829	91	25	of	of	ADP
admet-829	91	26	their	their	PRON
admet-829	91	27	gastric	gastric	ADJ
admet-829	91	28	emptying	empty	VERB
admet-829	91	29	(	(	PUNCT
admet-829	91	30	0	0	NUM
admet-829	91	31	,	,	PUNCT
admet-829	91	32	15	15	NUM
admet-829	91	33	,	,	PUNCT
admet-829	91	34	and	and	CCONJ
admet-829	91	35	30	30	NUM
admet-829	91	36	min	min	NOUN
admet-829	91	37	)	)	PUNCT
admet-829	91	38	were	be	AUX
admet-829	91	39	held	hold	VERB
admet-829	91	40	constant	constant	ADJ
admet-829	91	41	.	.	PUNCT
admet-829	92	1	the	the	DET
admet-829	92	2	spacing	spacing	NOUN
admet-829	92	3	of	of	ADP
admet-829	92	4	plug	plug	NOUN
admet-829	92	5	emptying	emptying	NOUN
admet-829	92	6	times	time	NOUN
admet-829	92	7	was	be	AUX
admet-829	92	8	intentionally	intentionally	ADV
admet-829	92	9	exaggerated	exaggerated	ADJ
admet-829	92	10	to	to	PART
admet-829	92	11	allow	allow	VERB
admet-829	92	12	visual	visual	ADJ
admet-829	92	13	distinction	distinction	NOUN
admet-829	92	14	between	between	ADP
admet-829	92	15	the	the	DET
admet-829	92	16	plugs	plug	NOUN
admet-829	92	17	.	.	PUNCT
admet-829	93	1	to	to	PART
admet-829	93	2	make	make	VERB
admet-829	93	3	more	more	ADV
admet-829	93	4	accurate	accurate	ADJ
admet-829	93	5	simulations	simulation	NOUN
admet-829	93	6	,	,	PUNCT
admet-829	93	7	the	the	DET
admet-829	93	8	number	number	NOUN
admet-829	93	9	,	,	PUNCT
admet-829	93	10	volumes	volume	NOUN
admet-829	93	11	,	,	PUNCT
admet-829	93	12	and	and	CCONJ
admet-829	93	13	emptying	empty	VERB
admet-829	93	14	times	time	NOUN
admet-829	93	15	of	of	ADP
admet-829	93	16	plugs	plug	NOUN
admet-829	93	17	should	should	AUX
admet-829	93	18	be	be	AUX
admet-829	93	19	selected	select	VERB
admet-829	93	20	to	to	PART
admet-829	93	21	agree	agree	VERB
admet-829	93	22	with	with	ADP
admet-829	93	23	emerging	emerge	VERB
admet-829	93	24	experimental	experimental	ADJ
admet-829	93	25	measurements	measurement	NOUN
admet-829	93	26	.	.	PUNCT
admet-829	94	1	figures	figure	NOUN
admet-829	94	2	2	2	NUM
admet-829	94	3	-	-	SYM
admet-829	94	4	4	4	NUM
admet-829	94	5	show	show	VERB
admet-829	94	6	the	the	DET
admet-829	94	7	individual	individual	ADJ
admet-829	94	8	plasma	plasma	NOUN
admet-829	94	9	compartment	compartment	NOUN
admet-829	94	10	drug	drug	NOUN
admet-829	94	11	concentrations	concentration	NOUN
admet-829	94	12	arising	arise	VERB
admet-829	94	13	from	from	ADP
admet-829	94	14	drug	drug	NOUN
admet-829	94	15	absorption	absorption	NOUN
admet-829	94	16	from	from	ADP
admet-829	94	17	individual	individual	ADJ
admet-829	94	18	plugs	plug	NOUN
admet-829	94	19	as	as	ADV
admet-829	94	20	well	well	ADV
admet-829	94	21	as	as	ADP
admet-829	94	22	the	the	DET
admet-829	94	23	total	total	ADJ
admet-829	94	24	drug	drug	NOUN
admet-829	94	25	concentration	concentration	NOUN
admet-829	94	26	from	from	ADP
admet-829	94	27	all	all	DET
admet-829	94	28	plugs	plug	NOUN
admet-829	94	29	.	.	PUNCT
admet-829	95	1	the	the	DET
admet-829	95	2	solid	solid	ADJ
admet-829	95	3	lines	line	NOUN
admet-829	95	4	represent	represent	VERB
admet-829	95	5	plasma	plasma	NOUN
admet-829	95	6	concentrations	concentration	NOUN
admet-829	95	7	using	use	VERB
admet-829	95	8	the	the	DET
admet-829	95	9	left	left	ADJ
admet-829	95	10	axis	axis	NOUN
admet-829	95	11	and	and	CCONJ
admet-829	95	12	dashed	dash	VERB
admet-829	95	13	lines	line	NOUN
admet-829	95	14	represent	represent	VERB
admet-829	95	15	absorption	absorption	NOUN
admet-829	95	16	rate	rate	NOUN
admet-829	95	17	constants	constant	NOUN
admet-829	95	18	using	use	VERB
admet-829	95	19	the	the	DET
admet-829	95	20	right	right	ADJ
admet-829	95	21	axis	axis	NOUN
admet-829	95	22	.	.	PUNCT
admet-829	96	1	for	for	ADP
admet-829	96	2	the	the	DET
admet-829	96	3	absorption	absorption	NOUN
admet-829	96	4	rate	rate	NOUN
admet-829	96	5	constant	constant	ADJ
admet-829	96	6	versus	versus	ADP
admet-829	96	7	time	time	NOUN
admet-829	96	8	profiles	profile	NOUN
admet-829	96	9	,	,	PUNCT
admet-829	96	10	the	the	DET
admet-829	96	11	sigmoidal	sigmoidal	NOUN
admet-829	96	12	shape	shape	NOUN
admet-829	96	13	of	of	ADP
admet-829	96	14	the	the	DET
admet-829	96	15	transition	transition	NOUN
admet-829	96	16	representing	represent	VERB
admet-829	96	17	gastric	gastric	ADJ
admet-829	96	18	emptying	empty	VERB
admet-829	96	19	is	be	AUX
admet-829	96	20	difficult	difficult	ADJ
admet-829	96	21	to	to	PART
admet-829	96	22	discern	discern	VERB
admet-829	96	23	,	,	PUNCT
admet-829	96	24	but	but	CCONJ
admet-829	96	25	it	it	PRON
admet-829	96	26	should	should	AUX
admet-829	96	27	be	be	AUX
admet-829	96	28	noted	note	VERB
admet-829	96	29	that	that	SCONJ
admet-829	96	30	it	it	PRON
admet-829	96	31	is	be	AUX
admet-829	96	32	not	not	PART
admet-829	96	33	an	an	DET
admet-829	96	34	abrupt	abrupt	ADJ
admet-829	96	35	change	change	NOUN
admet-829	96	36	.	.	PUNCT
admet-829	97	1	in	in	ADP
admet-829	97	2	figure	figure	NOUN
admet-829	97	3	2	2	NUM
admet-829	97	4	,	,	PUNCT
admet-829	97	5	the	the	DET
admet-829	97	6	concentration	concentration	NOUN
admet-829	97	7	profiles	profile	NOUN
admet-829	97	8	from	from	ADP
admet-829	97	9	individual	individual	ADJ
admet-829	97	10	plugs	plug	NOUN
admet-829	97	11	appear	appear	VERB
admet-829	97	12	to	to	PART
admet-829	97	13	have	have	VERB
admet-829	97	14	the	the	DET
admet-829	97	15	same	same	ADJ
admet-829	97	16	shape	shape	NOUN
admet-829	97	17	.	.	PUNCT
admet-829	98	1	this	this	PRON
admet-829	98	2	is	be	AUX
admet-829	98	3	because	because	SCONJ
admet-829	98	4	dissolution	dissolution	NOUN
admet-829	98	5	is	be	AUX
admet-829	98	6	essentially	essentially	ADV
admet-829	98	7	complete	complete	ADJ
admet-829	98	8	for	for	ADP
admet-829	98	9	all	all	DET
admet-829	98	10	plugs	plug	NOUN
admet-829	98	11	when	when	SCONJ
admet-829	98	12	they	they	PRON
admet-829	98	13	are	be	AUX
admet-829	98	14	simulated	simulate	VERB
admet-829	98	15	to	to	PART
admet-829	98	16	empty	empty	VERB
admet-829	98	17	from	from	ADP
admet-829	98	18	the	the	DET
admet-829	98	19	stomach	stomach	NOUN
admet-829	98	20	.	.	PUNCT
admet-829	99	1	in	in	ADP
admet-829	99	2	comparison	comparison	NOUN
admet-829	99	3	,	,	PUNCT
admet-829	99	4	the	the	DET
admet-829	99	5	individual	individual	ADJ
admet-829	99	6	profiles	profile	NOUN
admet-829	99	7	in	in	ADP
admet-829	99	8	figure	figure	NOUN
admet-829	99	9	3	3	NUM
admet-829	99	10	are	be	AUX
admet-829	99	11	clearly	clearly	ADV
admet-829	99	12	different	different	ADJ
admet-829	99	13	due	due	ADP
admet-829	99	14	to	to	ADP
admet-829	99	15	the	the	DET
admet-829	99	16	slower	slow	ADJ
admet-829	99	17	dissolution	dissolution	NOUN
admet-829	99	18	rate	rate	NOUN
admet-829	99	19	from	from	ADP
admet-829	99	20	larger	large	ADJ
admet-829	99	21	drug	drug	NOUN
admet-829	99	22	particles	particle	NOUN
admet-829	99	23	.	.	PUNCT
admet-829	100	1	in	in	ADP
admet-829	100	2	figure	figure	NOUN
admet-829	100	3	3	3	NUM
admet-829	100	4	,	,	PUNCT
admet-829	100	5	the	the	DET
admet-829	100	6	first	first	ADJ
admet-829	100	7	plug	plug	NOUN
admet-829	100	8	(	(	PUNCT
admet-829	100	9	red	red	PROPN
admet-829	100	10	)	)	PUNCT
admet-829	100	11	has	have	VERB
admet-829	100	12	significantly	significantly	ADV
admet-829	100	13	less	less	ADJ
admet-829	100	14	drug	drug	NOUN
admet-829	100	15	dissolved	dissolve	VERB
admet-829	100	16	than	than	ADP
admet-829	100	17	the	the	DET
admet-829	100	18	last	last	ADJ
admet-829	100	19	plug	plug	NOUN
admet-829	100	20	(	(	PUNCT
admet-829	100	21	green	green	NOUN
admet-829	100	22	)	)	PUNCT
admet-829	100	23	when	when	SCONJ
admet-829	100	24	they	they	PRON
admet-829	100	25	empty	empty	VERB
admet-829	100	26	from	from	ADP
admet-829	100	27	the	the	DET
admet-829	100	28	stomach	stomach	NOUN
admet-829	100	29	.	.	PUNCT
admet-829	101	1	this	this	PRON
admet-829	101	2	results	result	VERB
admet-829	101	3	in	in	ADP
admet-829	101	4	a	a	DET
admet-829	101	5	slower	slow	ADJ
admet-829	101	6	rate	rate	NOUN
admet-829	101	7	of	of	ADP
admet-829	101	8	drug	drug	NOUN
admet-829	101	9	absorption	absorption	NOUN
admet-829	101	10	from	from	ADP
admet-829	101	11	the	the	DET
admet-829	101	12	first	first	ADJ
admet-829	101	13	plug	plug	NOUN
admet-829	101	14	compared	compare	VERB
admet-829	101	15	to	to	ADP
admet-829	101	16	the	the	DET
admet-829	101	17	last	last	ADJ
admet-829	101	18	plug	plug	NOUN
admet-829	101	19	and	and	CCONJ
admet-829	101	20	illustrates	illustrate	VERB
admet-829	101	21	the	the	DET
admet-829	101	22	ability	ability	NOUN
admet-829	101	23	of	of	ADP
admet-829	101	24	the	the	DET
admet-829	101	25	mmp	mmp	PROPN
admet-829	101	26	model	model	NOUN
admet-829	101	27	to	to	PART
admet-829	101	28	model	model	VERB
admet-829	101	29	plugs	plug	NOUN
admet-829	101	30	independently	independently	ADV
admet-829	101	31	.	.	PUNCT
admet-829	102	1	figure	figure	VERB
admet-829	102	2	4	4	NUM
admet-829	102	3	illustrates	illustrate	VERB
admet-829	102	4	the	the	DET
admet-829	102	5	ability	ability	NOUN
admet-829	102	6	of	of	ADP
admet-829	102	7	the	the	DET
admet-829	102	8	mmp	mmp	PROPN
admet-829	102	9	model	model	NOUN
admet-829	102	10	to	to	PART
admet-829	102	11	simulate	simulate	VERB
admet-829	102	12	inhomogeneity	inhomogeneity	NOUN
admet-829	102	13	in	in	ADP
admet-829	102	14	the	the	DET
admet-829	102	15	stomach	stomach	NOUN
admet-829	102	16	by	by	ADP
admet-829	102	17	assigning	assign	VERB
admet-829	102	18	different	different	ADJ
admet-829	102	19	initial	initial	ADJ
admet-829	102	20	conditions	condition	NOUN
admet-829	102	21	to	to	ADP
admet-829	102	22	various	various	ADJ
admet-829	102	23	plugs	plug	NOUN
admet-829	102	24	.	.	PUNCT
admet-829	103	1	the	the	DET
admet-829	103	2	situation	situation	NOUN
admet-829	103	3	depicted	depict	VERB
admet-829	103	4	in	in	ADP
admet-829	103	5	figure	figure	NOUN
admet-829	103	6	4	4	NUM
admet-829	103	7	might	might	AUX
admet-829	103	8	arise	arise	VERB
admet-829	103	9	if	if	SCONJ
admet-829	103	10	a	a	DET
admet-829	103	11	dosage	dosage	NOUN
admet-829	103	12	form	form	NOUN
admet-829	103	13	does	do	AUX
admet-829	103	14	not	not	PART
admet-829	103	15	disintegrate	disintegrate	VERB
admet-829	103	16	immediately	immediately	ADV
admet-829	103	17	after	after	ADP
admet-829	103	18	ingestion	ingestion	NOUN
admet-829	103	19	with	with	ADP
admet-829	103	20	water	water	NOUN
admet-829	103	21	.	.	PUNCT
admet-829	104	1	in	in	ADP
admet-829	104	2	this	this	DET
admet-829	104	3	case	case	NOUN
admet-829	104	4	,	,	PUNCT
admet-829	104	5	the	the	DET
admet-829	104	6	first	first	ADJ
admet-829	104	7	plug	plug	NOUN
admet-829	104	8	of	of	ADP
admet-829	104	9	fluid	fluid	NOUN
admet-829	104	10	to	to	PART
admet-829	104	11	empty	empty	ADJ
admet-829	104	12	from	from	ADP
admet-829	104	13	the	the	DET
admet-829	104	14	stomach	stomach	NOUN
admet-829	104	15	does	do	AUX
admet-829	104	16	not	not	PART
admet-829	104	17	contain	contain	VERB
admet-829	104	18	any	any	DET
admet-829	104	19	drug	drug	NOUN
admet-829	104	20	.	.	PUNCT
admet-829	105	1	instead	instead	ADV
admet-829	105	2	,	,	PUNCT
admet-829	105	3	the	the	DET
admet-829	105	4	0.8	0.8	NUM
admet-829	105	5	mg	mg	NOUN
admet-829	105	6	of	of	ADP
admet-829	105	7	drug	drug	NOUN
admet-829	105	8	in	in	ADP
admet-829	105	9	the	the	DET
admet-829	105	10	first	first	ADJ
admet-829	105	11	plug	plug	NOUN
admet-829	105	12	in	in	ADP
admet-829	105	13	figure	figure	NOUN
admet-829	105	14	2	2	NUM
admet-829	105	15	was	be	AUX
admet-829	105	16	divided	divide	VERB
admet-829	105	17	evenly	evenly	ADV
admet-829	105	18	between	between	ADP
admet-829	105	19	the	the	DET
admet-829	105	20	second	second	ADJ
admet-829	105	21	and	and	CCONJ
admet-829	105	22	third	third	ADJ
admet-829	105	23	plugs	plug	NOUN
admet-829	105	24	.	.	PUNCT
admet-829	106	1	as	as	SCONJ
admet-829	106	2	expected	expect	VERB
admet-829	106	3	,	,	PUNCT
admet-829	106	4	there	there	PRON
admet-829	106	5	was	be	VERB
admet-829	106	6	a	a	DET
admet-829	106	7	delay	delay	NOUN
admet-829	106	8	in	in	ADP
admet-829	106	9	the	the	DET
admet-829	106	10	onset	onset	NOUN
admet-829	106	11	of	of	ADP
admet-829	106	12	drug	drug	NOUN
admet-829	106	13	absorption	absorption	NOUN
admet-829	106	14	in	in	ADP
admet-829	106	15	figure	figure	NOUN
admet-829	106	16	4	4	NUM
admet-829	106	17	relative	relative	ADJ
admet-829	106	18	to	to	PART
admet-829	106	19	figure	figure	VERB
admet-829	106	20	2	2	NUM
admet-829	106	21	.	.	PUNCT
admet-829	107	1	the	the	DET
admet-829	107	2	simulation	simulation	NOUN
admet-829	107	3	in	in	ADP
admet-829	107	4	figure	figure	NOUN
admet-829	107	5	4	4	NUM
admet-829	107	6	also	also	ADV
admet-829	107	7	resulted	result	VERB
admet-829	107	8	in	in	ADP
admet-829	107	9	a	a	DET
admet-829	107	10	higher	high	ADJ
admet-829	107	11	cmax	cmax	NOUN
admet-829	107	12	for	for	ADP
admet-829	107	13	the	the	DET
admet-829	107	14	total	total	ADJ
admet-829	107	15	drug	drug	NOUN
admet-829	107	16	concentration	concentration	NOUN
admet-829	107	17	compared	compare	VERB
admet-829	107	18	to	to	PART
admet-829	107	19	figure	figure	VERB
admet-829	107	20	2	2	NUM
admet-829	107	21	.	.	PUNCT
admet-829	107	22	figure	figure	NOUN
admet-829	107	23	2	2	NUM
admet-829	107	24	.	.	PUNCT
admet-829	107	25	simulated	simulate	VERB
admet-829	107	26	plasma	plasma	NOUN
admet-829	107	27	drug	drug	NOUN
admet-829	107	28	concentration	concentration	NOUN
admet-829	107	29	(	(	PUNCT
admet-829	107	30	left	leave	VERB
admet-829	107	31	axis	axis	NOUN
admet-829	107	32	)	)	PUNCT
admet-829	107	33	from	from	ADP
admet-829	107	34	3	3	NUM
admet-829	107	35	individual	individual	ADJ
admet-829	107	36	plugs	plug	NOUN
admet-829	107	37	(	(	PUNCT
admet-829	107	38	red	red	ADJ
admet-829	107	39	,	,	PUNCT
admet-829	107	40	blue	blue	ADJ
admet-829	107	41	,	,	PUNCT
admet-829	107	42	and	and	CCONJ
admet-829	107	43	green	green	ADJ
admet-829	107	44	solid	solid	ADJ
admet-829	107	45	lines	line	NOUN
admet-829	107	46	)	)	PUNCT
admet-829	107	47	as	as	ADV
admet-829	107	48	well	well	ADV
admet-829	107	49	as	as	ADP
admet-829	107	50	the	the	DET
admet-829	107	51	summation	summation	NOUN
admet-829	107	52	of	of	ADP
admet-829	107	53	all	all	DET
admet-829	107	54	plugs	plug	NOUN
admet-829	107	55	(	(	PUNCT
admet-829	107	56	black	black	ADJ
admet-829	107	57	solid	solid	ADJ
admet-829	107	58	line	line	NOUN
admet-829	107	59	)	)	PUNCT
admet-829	107	60	.	.	PUNCT
admet-829	108	1	absorption	absorption	NOUN
admet-829	108	2	from	from	ADP
admet-829	108	3	individual	individual	ADJ
admet-829	108	4	plugs	plug	NOUN
admet-829	108	5	begins	begin	VERB
admet-829	108	6	at	at	ADP
admet-829	108	7	the	the	DET
admet-829	108	8	onset	onset	NOUN
admet-829	108	9	of	of	ADP
admet-829	108	10	the	the	DET
admet-829	108	11	absorption	absorption	NOUN
admet-829	108	12	rate	rate	NOUN
admet-829	108	13	constant	constant	ADJ
admet-829	108	14	transitioning	transitioning	NOUN
admet-829	108	15	from	from	ADP
admet-829	108	16	0	0	NUM
admet-829	108	17	to	to	PART
admet-829	108	18	0.07	0.07	NUM
admet-829	108	19	min	min	NOUN
admet-829	108	20	-1	-1	PUNCT
admet-829	108	21	shown	show	VERB
admet-829	108	22	as	as	ADP
admet-829	108	23	dashed	dash	VERB
admet-829	108	24	lines	line	NOUN
admet-829	108	25	and	and	CCONJ
admet-829	108	26	scaled	scale	VERB
admet-829	108	27	using	use	VERB
admet-829	108	28	the	the	DET
admet-829	108	29	right	right	ADJ
admet-829	108	30	axis	axis	NOUN
admet-829	108	31	.	.	PUNCT
admet-829	109	1	table	table	NOUN
admet-829	109	2	4	4	NUM
admet-829	109	3	lists	list	NOUN
admet-829	109	4	figure	figure	VERB
admet-829	109	5	specific	specific	ADJ
admet-829	109	6	simulation	simulation	NOUN
admet-829	109	7	parameters	parameter	NOUN
admet-829	109	8	.	.	PUNCT
admet-829	110	1	admet	admet	PROPN
admet-829	110	2	&	&	CCONJ
admet-829	110	3	dmpk	dmpk	PROPN
admet-829	110	4	8(3	8(3	NUM
admet-829	110	5	)	)	PUNCT
admet-829	110	6	(	(	PUNCT
admet-829	110	7	2020	2020	NUM
admet-829	110	8	)	)	PUNCT
admet-829	110	9	314	314	NUM
admet-829	110	10	-	-	SYM
admet-829	110	11	324	324	NUM
admet-829	110	12	mechanistic	mechanistic	ADJ
admet-829	110	13	modeling	modeling	NOUN
admet-829	110	14	of	of	ADP
admet-829	110	15	gastrointestinal	gastrointestinal	ADJ
admet-829	110	16	motility	motility	NOUN
admet-829	110	17	doi	doi	NOUN
admet-829	110	18	:	:	PUNCT
admet-829	110	19	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	NOUN
admet-829	110	20	319	319	NUM
admet-829	110	21	figure	figure	NOUN
admet-829	110	22	3	3	NUM
admet-829	110	23	.	.	PUNCT
admet-829	110	24	simulated	simulate	VERB
admet-829	110	25	plasma	plasma	NOUN
admet-829	110	26	drug	drug	NOUN
admet-829	110	27	concentration	concentration	NOUN
admet-829	110	28	(	(	PUNCT
admet-829	110	29	left	leave	VERB
admet-829	110	30	axis	axis	NOUN
admet-829	110	31	)	)	PUNCT
admet-829	110	32	from	from	ADP
admet-829	110	33	3	3	NUM
admet-829	110	34	individual	individual	ADJ
admet-829	110	35	plugs	plug	NOUN
admet-829	110	36	(	(	PUNCT
admet-829	110	37	red	red	ADJ
admet-829	110	38	,	,	PUNCT
admet-829	110	39	blue	blue	ADJ
admet-829	110	40	,	,	PUNCT
admet-829	110	41	and	and	CCONJ
admet-829	110	42	green	green	ADJ
admet-829	110	43	solid	solid	ADJ
admet-829	110	44	lines	line	NOUN
admet-829	110	45	)	)	PUNCT
admet-829	110	46	as	as	ADV
admet-829	110	47	well	well	ADV
admet-829	110	48	as	as	ADP
admet-829	110	49	the	the	DET
admet-829	110	50	summation	summation	NOUN
admet-829	110	51	of	of	ADP
admet-829	110	52	all	all	DET
admet-829	110	53	plugs	plug	NOUN
admet-829	110	54	(	(	PUNCT
admet-829	110	55	black	black	ADJ
admet-829	110	56	solid	solid	ADJ
admet-829	110	57	line	line	NOUN
admet-829	110	58	)	)	PUNCT
admet-829	110	59	.	.	PUNCT
admet-829	111	1	absorption	absorption	NOUN
admet-829	111	2	from	from	ADP
admet-829	111	3	individual	individual	ADJ
admet-829	111	4	plugs	plug	NOUN
admet-829	111	5	begins	begin	VERB
admet-829	111	6	at	at	ADP
admet-829	111	7	the	the	DET
admet-829	111	8	onset	onset	NOUN
admet-829	111	9	of	of	ADP
admet-829	111	10	the	the	DET
admet-829	111	11	absorption	absorption	NOUN
admet-829	111	12	rate	rate	NOUN
admet-829	111	13	constant	constant	ADJ
admet-829	111	14	transitioning	transitioning	NOUN
admet-829	111	15	from	from	ADP
admet-829	111	16	0	0	NUM
admet-829	111	17	to	to	PART
admet-829	111	18	0.07	0.07	NUM
admet-829	111	19	min	min	NOUN
admet-829	111	20	-1	-1	PUNCT
admet-829	111	21	shown	show	VERB
admet-829	111	22	as	as	ADP
admet-829	111	23	dashed	dash	VERB
admet-829	111	24	lines	line	NOUN
admet-829	111	25	and	and	CCONJ
admet-829	111	26	scaled	scale	VERB
admet-829	111	27	using	use	VERB
admet-829	111	28	the	the	DET
admet-829	111	29	right	right	ADJ
admet-829	111	30	axis	axis	NOUN
admet-829	111	31	.	.	PUNCT
admet-829	112	1	table	table	NOUN
admet-829	112	2	4	4	NUM
admet-829	112	3	lists	list	NOUN
admet-829	112	4	figure	figure	VERB
admet-829	112	5	specific	specific	ADJ
admet-829	112	6	simulation	simulation	NOUN
admet-829	112	7	parameters	parameter	NOUN
admet-829	112	8	.	.	PUNCT
admet-829	113	1	figure	figure	NOUN
admet-829	113	2	3	3	NUM
admet-829	113	3	uses	use	VERB
admet-829	113	4	a	a	DET
admet-829	113	5	larger	large	ADJ
admet-829	113	6	drug	drug	NOUN
admet-829	113	7	particle	particle	NOUN
admet-829	113	8	size	size	NOUN
admet-829	113	9	compared	compare	VERB
admet-829	113	10	to	to	PART
admet-829	113	11	figure	figure	VERB
admet-829	113	12	2	2	NUM
admet-829	113	13	.	.	PUNCT
admet-829	113	14	figure	figure	NOUN
admet-829	113	15	5	5	NUM
admet-829	113	16	compares	compare	VERB
admet-829	113	17	the	the	DET
admet-829	113	18	summation	summation	NOUN
admet-829	113	19	plasma	plasma	NOUN
admet-829	113	20	concentration	concentration	NOUN
admet-829	113	21	profiles	profile	NOUN
admet-829	113	22	in	in	ADP
admet-829	113	23	figures	figure	NOUN
admet-829	113	24	2	2	NUM
admet-829	113	25	-	-	SYM
admet-829	113	26	4	4	NUM
admet-829	113	27	as	as	ADV
admet-829	113	28	well	well	ADV
admet-829	113	29	as	as	ADP
admet-829	113	30	a	a	DET
admet-829	113	31	new	new	ADJ
admet-829	113	32	simulation	simulation	NOUN
admet-829	113	33	for	for	ADP
admet-829	113	34	absorption	absorption	NOUN
admet-829	113	35	of	of	ADP
admet-829	113	36	the	the	DET
admet-829	113	37	same	same	ADJ
admet-829	113	38	total	total	NOUN
admet-829	113	39	dose	dose	NOUN
admet-829	113	40	from	from	ADP
admet-829	113	41	a	a	DET
admet-829	113	42	single	single	ADJ
admet-829	113	43	plug	plug	NOUN
admet-829	113	44	to	to	PART
admet-829	113	45	serve	serve	VERB
admet-829	113	46	as	as	ADP
admet-829	113	47	a	a	DET
admet-829	113	48	reference	reference	NOUN
admet-829	113	49	point	point	NOUN
admet-829	113	50	.	.	PUNCT
admet-829	114	1	in	in	ADP
admet-829	114	2	general	general	ADJ
admet-829	114	3	,	,	PUNCT
admet-829	114	4	simulating	simulate	VERB
admet-829	114	5	gastric	gastric	ADJ
admet-829	114	6	emptying	empty	VERB
admet-829	114	7	as	as	ADP
admet-829	114	8	a	a	DET
admet-829	114	9	sequential	sequential	ADJ
admet-829	114	10	movement	movement	NOUN
admet-829	114	11	of	of	ADP
admet-829	114	12	a	a	DET
admet-829	114	13	series	series	NOUN
admet-829	114	14	of	of	ADP
admet-829	114	15	independent	independent	ADJ
admet-829	114	16	plugs	plug	NOUN
admet-829	114	17	of	of	ADP
admet-829	114	18	fluid	fluid	NOUN
admet-829	114	19	from	from	ADP
admet-829	114	20	the	the	DET
admet-829	114	21	stomach	stomach	NOUN
admet-829	114	22	to	to	ADP
admet-829	114	23	the	the	DET
admet-829	114	24	intestine	intestine	NOUN
admet-829	114	25	resulted	result	VERB
admet-829	114	26	in	in	ADP
admet-829	114	27	a	a	DET
admet-829	114	28	reduced	reduced	ADJ
admet-829	114	29	cmax	cmax	NOUN
admet-829	114	30	and	and	CCONJ
admet-829	114	31	increased	increase	VERB
admet-829	114	32	tmax	tmax	ADV
admet-829	114	33	compared	compare	VERB
admet-829	114	34	to	to	ADP
admet-829	114	35	a	a	DET
admet-829	114	36	single	single	ADJ
admet-829	114	37	plug	plug	NOUN
admet-829	114	38	.	.	PUNCT
admet-829	115	1	figure	figure	NOUN
admet-829	115	2	4	4	NUM
admet-829	115	3	.	.	PUNCT
admet-829	115	4	simulated	simulate	VERB
admet-829	115	5	plasma	plasma	NOUN
admet-829	115	6	drug	drug	NOUN
admet-829	115	7	concentration	concentration	NOUN
admet-829	115	8	(	(	PUNCT
admet-829	115	9	left	leave	VERB
admet-829	115	10	axis	axis	NOUN
admet-829	115	11	)	)	PUNCT
admet-829	115	12	from	from	ADP
admet-829	115	13	3	3	NUM
admet-829	115	14	individual	individual	ADJ
admet-829	115	15	plugs	plug	NOUN
admet-829	115	16	(	(	PUNCT
admet-829	115	17	red	red	ADJ
admet-829	115	18	,	,	PUNCT
admet-829	115	19	blue	blue	ADJ
admet-829	115	20	,	,	PUNCT
admet-829	115	21	and	and	CCONJ
admet-829	115	22	green	green	ADJ
admet-829	115	23	solid	solid	ADJ
admet-829	115	24	lines	line	NOUN
admet-829	115	25	)	)	PUNCT
admet-829	115	26	as	as	ADV
admet-829	115	27	well	well	ADV
admet-829	115	28	as	as	ADP
admet-829	115	29	the	the	DET
admet-829	115	30	summation	summation	NOUN
admet-829	115	31	of	of	ADP
admet-829	115	32	all	all	DET
admet-829	115	33	plugs	plug	NOUN
admet-829	115	34	(	(	PUNCT
admet-829	115	35	black	black	ADJ
admet-829	115	36	solid	solid	ADJ
admet-829	115	37	line	line	NOUN
admet-829	115	38	)	)	PUNCT
admet-829	115	39	.	.	PUNCT
admet-829	116	1	absorption	absorption	NOUN
admet-829	116	2	from	from	ADP
admet-829	116	3	individual	individual	ADJ
admet-829	116	4	plugs	plug	NOUN
admet-829	116	5	begins	begin	VERB
admet-829	116	6	at	at	ADP
admet-829	116	7	the	the	DET
admet-829	116	8	onset	onset	NOUN
admet-829	116	9	of	of	ADP
admet-829	116	10	the	the	DET
admet-829	116	11	absorption	absorption	NOUN
admet-829	116	12	rate	rate	NOUN
admet-829	116	13	constant	constant	ADJ
admet-829	116	14	transitioning	transitioning	NOUN
admet-829	116	15	from	from	ADP
admet-829	116	16	0	0	NUM
admet-829	116	17	to	to	PART
admet-829	116	18	0.07	0.07	NUM
admet-829	116	19	min	min	NOUN
admet-829	116	20	-1	-1	PUNCT
admet-829	116	21	shown	show	VERB
admet-829	116	22	as	as	ADP
admet-829	116	23	dashed	dash	VERB
admet-829	116	24	lines	line	NOUN
admet-829	116	25	and	and	CCONJ
admet-829	116	26	scaled	scale	VERB
admet-829	116	27	using	use	VERB
admet-829	116	28	the	the	DET
admet-829	116	29	right	right	ADJ
admet-829	116	30	axis	axis	NOUN
admet-829	116	31	.	.	PUNCT
admet-829	117	1	table	table	NOUN
admet-829	117	2	4	4	NUM
admet-829	117	3	lists	list	NOUN
admet-829	117	4	figure	figure	VERB
admet-829	117	5	specific	specific	ADJ
admet-829	117	6	simulation	simulation	NOUN
admet-829	117	7	parameters	parameter	NOUN
admet-829	117	8	.	.	PUNCT
admet-829	118	1	figure	figure	NOUN
admet-829	118	2	4	4	NUM
admet-829	118	3	removes	remove	VERB
admet-829	118	4	the	the	DET
admet-829	118	5	amount	amount	NOUN
admet-829	118	6	of	of	ADP
admet-829	118	7	drug	drug	NOUN
admet-829	118	8	in	in	ADP
admet-829	118	9	the	the	DET
admet-829	118	10	first	first	ADJ
admet-829	118	11	plug	plug	NOUN
admet-829	118	12	and	and	CCONJ
admet-829	118	13	splits	split	VERB
admet-829	118	14	it	it	PRON
admet-829	118	15	evenly	evenly	ADV
admet-829	118	16	between	between	ADP
admet-829	118	17	the	the	DET
admet-829	118	18	second	second	ADJ
admet-829	118	19	and	and	CCONJ
admet-829	118	20	third	third	ADJ
admet-829	118	21	plugs	plug	NOUN
admet-829	118	22	compared	compare	VERB
admet-829	118	23	to	to	PART
admet-829	118	24	figure	figure	VERB
admet-829	118	25	2	2	NUM
admet-829	118	26	.	.	PUNCT
admet-829	118	27	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	118	28	kevin	kevin	PROPN
admet-829	118	29	c.	c.	PROPN
admet-829	118	30	johnson	johnson	PROPN
admet-829	118	31	admet	admet	PROPN
admet-829	118	32	&	&	CCONJ
admet-829	118	33	dmpk	dmpk	PROPN
admet-829	118	34	8(3	8(3	NUM
admet-829	118	35	)	)	PUNCT
admet-829	118	36	(	(	PUNCT
admet-829	118	37	2020	2020	NUM
admet-829	118	38	)	)	PUNCT
admet-829	118	39	314	314	NUM
admet-829	118	40	-	-	SYM
admet-829	118	41	324	324	NUM
admet-829	118	42	320	320	NUM
admet-829	118	43	figure	figure	NOUN
admet-829	118	44	5	5	NUM
admet-829	118	45	.	.	PUNCT
admet-829	118	46	simulated	simulate	VERB
admet-829	118	47	plasma	plasma	NOUN
admet-829	118	48	drug	drug	NOUN
admet-829	118	49	concentration	concentration	NOUN
admet-829	118	50	(	(	PUNCT
admet-829	118	51	summation	summation	NOUN
admet-829	118	52	only	only	ADV
admet-829	118	53	)	)	PUNCT
admet-829	118	54	from	from	ADP
admet-829	118	55	figure	figure	NOUN
admet-829	118	56	2	2	NUM
admet-829	118	57	(	(	PUNCT
admet-829	118	58	gray	gray	ADJ
admet-829	118	59	line	line	NOUN
admet-829	118	60	)	)	PUNCT
admet-829	118	61	,	,	PUNCT
admet-829	118	62	figure	figure	NOUN
admet-829	118	63	3	3	NUM
admet-829	118	64	(	(	PUNCT
admet-829	118	65	dashed	dash	VERB
admet-829	118	66	line	line	NOUN
admet-829	118	67	)	)	PUNCT
admet-829	118	68	,	,	PUNCT
admet-829	118	69	and	and	CCONJ
admet-829	118	70	figure	figure	VERB
admet-829	118	71	4	4	NUM
admet-829	118	72	(	(	PUNCT
admet-829	118	73	solid	solid	ADJ
admet-829	118	74	thinner	thin	ADJ
admet-829	118	75	line	line	NOUN
admet-829	118	76	)	)	PUNCT
admet-829	118	77	compared	compare	VERB
admet-829	118	78	to	to	ADP
admet-829	118	79	a	a	DET
admet-829	118	80	one	one	NUM
admet-829	118	81	-	-	PUNCT
admet-829	118	82	plug	plug	NOUN
admet-829	118	83	simulation	simulation	NOUN
admet-829	118	84	for	for	ADP
admet-829	118	85	reference	reference	NOUN
admet-829	118	86	(	(	PUNCT
admet-829	118	87	solid	solid	ADJ
admet-829	118	88	heavier	heavy	ADJ
admet-829	118	89	line	line	NOUN
admet-829	118	90	)	)	PUNCT
admet-829	118	91	that	that	PRON
admet-829	118	92	emptied	empty	VERB
admet-829	118	93	from	from	ADP
admet-829	118	94	the	the	DET
admet-829	118	95	stomach	stomach	NOUN
admet-829	118	96	using	use	VERB
admet-829	118	97	the	the	DET
admet-829	118	98	absorption	absorption	NOUN
admet-829	118	99	rate	rate	NOUN
admet-829	118	100	constant	constant	ADJ
admet-829	118	101	transition	transition	NOUN
admet-829	118	102	for	for	ADP
admet-829	118	103	the	the	DET
admet-829	118	104	first	first	ADJ
admet-829	118	105	plug	plug	NOUN
admet-829	118	106	in	in	ADP
admet-829	118	107	figures	figure	NOUN
admet-829	118	108	2	2	NUM
admet-829	118	109	-	-	SYM
admet-829	118	110	4	4	NUM
admet-829	118	111	.	.	PUNCT
admet-829	119	1	the	the	DET
admet-829	119	2	mmp	mmp	PROPN
admet-829	119	3	model	model	NOUN
admet-829	119	4	invokes	invoke	VERB
admet-829	119	5	the	the	DET
admet-829	119	6	need	need	NOUN
admet-829	119	7	for	for	ADP
admet-829	119	8	real	real	ADJ
admet-829	119	9	time	time	NOUN
admet-829	119	10	data	datum	NOUN
admet-829	119	11	on	on	ADP
admet-829	119	12	the	the	DET
admet-829	119	13	number	number	NOUN
admet-829	119	14	,	,	PUNCT
admet-829	119	15	timing	timing	NOUN
admet-829	119	16	,	,	PUNCT
admet-829	119	17	and	and	CCONJ
admet-829	119	18	volume	volume	NOUN
admet-829	119	19	of	of	ADP
admet-829	119	20	fluid	fluid	ADJ
admet-829	119	21	plugs	plug	NOUN
admet-829	119	22	emptying	empty	VERB
admet-829	119	23	from	from	ADP
admet-829	119	24	the	the	DET
admet-829	119	25	stomach	stomach	NOUN
admet-829	119	26	and	and	CCONJ
admet-829	119	27	moving	move	VERB
admet-829	119	28	through	through	ADP
admet-829	119	29	the	the	DET
admet-829	119	30	intestine	intestine	NOUN
admet-829	119	31	.	.	PUNCT
admet-829	120	1	schiller	schiller	PROPN
admet-829	120	2	et	et	PROPN
admet-829	120	3	al	al	PROPN
admet-829	120	4	.	.	PUNCT
admet-829	121	1	[	[	X
admet-829	121	2	6	6	NUM
admet-829	121	3	]	]	PUNCT
admet-829	121	4	reported	report	VERB
admet-829	121	5	a	a	DET
admet-829	121	6	mean	mean	ADJ
admet-829	121	7	small	small	ADJ
admet-829	121	8	intestinal	intestinal	ADJ
admet-829	121	9	fluid	fluid	NOUN
admet-829	121	10	volume	volume	NOUN
admet-829	121	11	of	of	ADP
admet-829	121	12	105	105	NUM
admet-829	121	13	ml	ml	NOUN
admet-829	121	14	contained	contain	VERB
admet-829	121	15	in	in	ADP
admet-829	121	16	a	a	DET
admet-829	121	17	mean	mean	ADJ
admet-829	121	18	number	number	NOUN
admet-829	121	19	of	of	ADP
admet-829	121	20	separated	separate	VERB
admet-829	121	21	fluid	fluid	ADJ
admet-829	121	22	pockets	pocket	NOUN
admet-829	121	23	of	of	ADP
admet-829	121	24	4	4	NUM
admet-829	121	25	.	.	PUNCT
admet-829	122	1	however	however	ADV
admet-829	122	2	,	,	PUNCT
admet-829	122	3	this	this	DET
admet-829	122	4	assessment	assessment	NOUN
admet-829	122	5	was	be	AUX
admet-829	122	6	a	a	DET
admet-829	122	7	one	one	NUM
admet-829	122	8	-	-	PUNCT
admet-829	122	9	time	time	NOUN
admet-829	122	10	observation	observation	NOUN
admet-829	122	11	made	make	VERB
admet-829	122	12	1	1	NUM
admet-829	122	13	hour	hour	NOUN
admet-829	122	14	after	after	ADP
admet-829	122	15	the	the	DET
admet-829	122	16	last	last	ADJ
admet-829	122	17	dose	dose	NOUN
admet-829	122	18	in	in	ADP
admet-829	122	19	a	a	DET
admet-829	122	20	sequence	sequence	NOUN
admet-829	122	21	of	of	ADP
admet-829	122	22	nondisintegrating	nondisintegrating	NOUN
admet-829	122	23	marker	marker	NOUN
admet-829	122	24	capsules	capsule	NOUN
admet-829	122	25	was	be	AUX
admet-829	122	26	given	give	VERB
admet-829	122	27	in	in	ADP
admet-829	122	28	the	the	DET
admet-829	122	29	fasting	fast	VERB
admet-829	122	30	state	state	NOUN
admet-829	122	31	.	.	PUNCT
admet-829	123	1	mudie	mudie	PROPN
admet-829	123	2	et	et	PROPN
admet-829	123	3	al	al	PROPN
admet-829	123	4	.	.	PUNCT
admet-829	124	1	[	[	X
admet-829	124	2	4	4	X
admet-829	124	3	]	]	PUNCT
admet-829	124	4	tracked	track	VERB
admet-829	124	5	the	the	DET
admet-829	124	6	number	number	NOUN
admet-829	124	7	,	,	PUNCT
admet-829	124	8	volume	volume	NOUN
admet-829	124	9	,	,	PUNCT
admet-829	124	10	and	and	CCONJ
admet-829	124	11	approximate	approximate	ADJ
admet-829	124	12	location	location	NOUN
admet-829	124	13	of	of	ADP
admet-829	124	14	fluid	fluid	ADJ
admet-829	124	15	packets	packet	NOUN
admet-829	124	16	at	at	ADP
admet-829	124	17	fixed	fix	VERB
admet-829	124	18	time	time	NOUN
admet-829	124	19	points	point	NOUN
admet-829	124	20	.	.	PUNCT
admet-829	125	1	after	after	ADP
admet-829	125	2	dosing	dose	VERB
admet-829	125	3	240	240	NUM
admet-829	125	4	ml	ml	NOUN
admet-829	125	5	of	of	ADP
admet-829	125	6	water	water	NOUN
admet-829	125	7	in	in	ADP
admet-829	125	8	the	the	DET
admet-829	125	9	fasted	fasted	ADJ
admet-829	125	10	state	state	NOUN
admet-829	125	11	,	,	PUNCT
admet-829	125	12	the	the	DET
admet-829	125	13	number	number	NOUN
admet-829	125	14	of	of	ADP
admet-829	125	15	small	small	ADJ
admet-829	125	16	intestinal	intestinal	ADJ
admet-829	125	17	water	water	NOUN
admet-829	125	18	pockets	pocket	NOUN
admet-829	125	19	increased	increase	VERB
admet-829	125	20	from	from	ADP
admet-829	125	21	about	about	ADV
admet-829	125	22	8	8	NUM
admet-829	125	23	initially	initially	ADV
admet-829	125	24	to	to	ADP
admet-829	125	25	about	about	ADV
admet-829	125	26	16	16	NUM
admet-829	125	27	before	before	ADP
admet-829	125	28	decreasing	decrease	VERB
admet-829	125	29	gradually	gradually	ADV
admet-829	125	30	over	over	ADP
admet-829	125	31	the	the	DET
admet-829	125	32	2	2	NUM
admet-829	125	33	-	-	PUNCT
admet-829	125	34	hour	hour	NOUN
admet-829	125	35	time	time	NOUN
admet-829	125	36	period	period	NOUN
admet-829	125	37	studied	study	VERB
admet-829	125	38	.	.	PUNCT
admet-829	126	1	the	the	DET
admet-829	126	2	mean	mean	ADJ
admet-829	126	3	volume	volume	NOUN
admet-829	126	4	of	of	ADP
admet-829	126	5	the	the	DET
admet-829	126	6	pockets	pocket	NOUN
admet-829	126	7	was	be	AUX
admet-829	126	8	in	in	ADP
admet-829	126	9	the	the	DET
admet-829	126	10	3	3	NUM
admet-829	126	11	-	-	SYM
admet-829	126	12	7	7	NUM
admet-829	126	13	ml	ml	NOUN
admet-829	126	14	range	range	NOUN
admet-829	126	15	.	.	PUNCT
admet-829	127	1	mudie	mudie	PROPN
admet-829	127	2	et	et	PROPN
admet-829	127	3	al	al	PROPN
admet-829	127	4	.	.	PUNCT
admet-829	128	1	[	[	X
admet-829	128	2	4	4	X
admet-829	128	3	]	]	PUNCT
admet-829	128	4	acknowledge	acknowledge	VERB
admet-829	128	5	that	that	SCONJ
admet-829	128	6	it	it	PRON
admet-829	128	7	is	be	AUX
admet-829	128	8	possible	possible	ADJ
admet-829	128	9	that	that	SCONJ
admet-829	128	10	a	a	DET
admet-829	128	11	significant	significant	ADJ
admet-829	128	12	portion	portion	NOUN
admet-829	128	13	of	of	ADP
admet-829	128	14	the	the	DET
admet-829	128	15	dose	dose	NOUN
admet-829	128	16	could	could	AUX
admet-829	128	17	be	be	AUX
admet-829	128	18	confined	confine	VERB
admet-829	128	19	to	to	ADP
admet-829	128	20	just	just	ADV
admet-829	128	21	a	a	DET
admet-829	128	22	few	few	ADJ
admet-829	128	23	pockets	pocket	NOUN
admet-829	128	24	.	.	PUNCT
admet-829	129	1	this	this	PRON
admet-829	129	2	suggests	suggest	VERB
admet-829	129	3	that	that	SCONJ
admet-829	129	4	the	the	DET
admet-829	129	5	focus	focus	NOUN
admet-829	129	6	should	should	AUX
admet-829	129	7	be	be	AUX
admet-829	129	8	on	on	ADP
admet-829	129	9	the	the	DET
admet-829	129	10	fluid	fluid	NOUN
admet-829	129	11	that	that	PRON
admet-829	129	12	is	be	AUX
admet-829	129	13	likely	likely	ADJ
admet-829	129	14	to	to	PART
admet-829	129	15	contain	contain	VERB
admet-829	129	16	drug	drug	NOUN
admet-829	129	17	at	at	ADP
admet-829	129	18	the	the	DET
admet-829	129	19	time	time	NOUN
admet-829	129	20	of	of	ADP
admet-829	129	21	dosing	dosing	NOUN
admet-829	129	22	and	and	CCONJ
admet-829	129	23	on	on	ADP
admet-829	129	24	its	its	PRON
admet-829	129	25	movement	movement	NOUN
admet-829	129	26	thereafter	thereafter	ADV
admet-829	129	27	.	.	PUNCT
admet-829	130	1	it	it	PRON
admet-829	130	2	may	may	AUX
admet-829	130	3	also	also	ADV
admet-829	130	4	be	be	AUX
admet-829	130	5	possible	possible	ADJ
admet-829	130	6	to	to	ADP
admet-829	130	7	group	group	NOUN
admet-829	130	8	fluid	fluid	NOUN
admet-829	130	9	that	that	PRON
admet-829	130	10	empties	empty	NOUN
admet-829	130	11	from	from	ADP
admet-829	130	12	the	the	DET
admet-829	130	13	stomach	stomach	NOUN
admet-829	130	14	over	over	ADP
admet-829	130	15	a	a	DET
admet-829	130	16	certain	certain	ADJ
admet-829	130	17	time	time	NOUN
admet-829	130	18	range	range	NOUN
admet-829	130	19	to	to	PART
admet-829	130	20	reduce	reduce	VERB
admet-829	130	21	the	the	DET
admet-829	130	22	number	number	NOUN
admet-829	130	23	of	of	ADP
admet-829	130	24	fluid	fluid	ADJ
admet-829	130	25	plugs	plug	NOUN
admet-829	130	26	while	while	SCONJ
admet-829	130	27	retaining	retain	VERB
admet-829	130	28	the	the	DET
admet-829	130	29	characteristics	characteristic	NOUN
admet-829	130	30	of	of	ADP
admet-829	130	31	the	the	DET
admet-829	130	32	mmp	mmp	PROPN
admet-829	130	33	model	model	NOUN
admet-829	130	34	.	.	PUNCT
admet-829	131	1	the	the	DET
admet-829	131	2	advantage	advantage	NOUN
admet-829	131	3	in	in	ADP
admet-829	131	4	doing	do	VERB
admet-829	131	5	so	so	ADV
admet-829	131	6	is	be	AUX
admet-829	131	7	to	to	PART
admet-829	131	8	reduce	reduce	VERB
admet-829	131	9	the	the	DET
admet-829	131	10	computational	computational	ADJ
admet-829	131	11	time	time	NOUN
admet-829	131	12	required	require	VERB
admet-829	131	13	to	to	PART
admet-829	131	14	run	run	VERB
admet-829	131	15	a	a	DET
admet-829	131	16	simulation	simulation	NOUN
admet-829	131	17	.	.	PUNCT
admet-829	132	1	the	the	DET
admet-829	132	2	same	same	ADJ
admet-829	132	3	strategy	strategy	NOUN
admet-829	132	4	has	have	AUX
admet-829	132	5	been	be	AUX
admet-829	132	6	applied	apply	VERB
admet-829	132	7	successfully	successfully	ADV
admet-829	132	8	for	for	ADP
admet-829	132	9	simulating	simulate	VERB
admet-829	132	10	the	the	DET
admet-829	132	11	dissolution	dissolution	NOUN
admet-829	132	12	of	of	ADP
admet-829	132	13	polydisperse	polydisperse	NOUN
admet-829	132	14	drug	drug	NOUN
admet-829	132	15	powders	powder	NOUN
admet-829	132	16	by	by	ADP
admet-829	132	17	grouping	group	VERB
admet-829	132	18	drug	drug	NOUN
admet-829	132	19	particles	particle	NOUN
admet-829	132	20	within	within	ADP
admet-829	132	21	a	a	DET
admet-829	132	22	certain	certain	ADJ
admet-829	132	23	size	size	NOUN
admet-829	132	24	range	range	VERB
admet-829	132	25	into	into	ADP
admet-829	132	26	a	a	DET
admet-829	132	27	single	single	ADJ
admet-829	132	28	size	size	NOUN
admet-829	132	29	group	group	NOUN
admet-829	132	30	that	that	PRON
admet-829	132	31	is	be	AUX
admet-829	132	32	representative	representative	NOUN
admet-829	132	33	of	of	ADP
admet-829	132	34	the	the	DET
admet-829	132	35	range	range	NOUN
admet-829	132	36	.	.	PUNCT
admet-829	133	1	figure	figure	NOUN
admet-829	133	2	6	6	NUM
admet-829	133	3	compares	compare	VERB
admet-829	133	4	the	the	DET
admet-829	133	5	simulation	simulation	NOUN
admet-829	133	6	in	in	ADP
admet-829	133	7	figure	figure	NOUN
admet-829	133	8	2	2	NUM
admet-829	133	9	with	with	ADP
admet-829	133	10	a	a	DET
admet-829	133	11	simulation	simulation	NOUN
admet-829	133	12	where	where	SCONJ
admet-829	133	13	the	the	DET
admet-829	133	14	only	only	ADJ
admet-829	133	15	differences	difference	NOUN
admet-829	133	16	are	be	AUX
admet-829	133	17	an	an	DET
admet-829	133	18	increase	increase	NOUN
admet-829	133	19	in	in	ADP
admet-829	133	20	the	the	DET
admet-829	133	21	number	number	NOUN
admet-829	133	22	of	of	ADP
admet-829	133	23	plugs	plug	NOUN
admet-829	133	24	from	from	ADP
admet-829	133	25	3	3	NUM
admet-829	133	26	to	to	ADP
admet-829	133	27	7	7	NUM
admet-829	133	28	and	and	CCONJ
admet-829	133	29	a	a	DET
admet-829	133	30	decrease	decrease	NOUN
admet-829	133	31	in	in	ADP
admet-829	133	32	the	the	DET
admet-829	133	33	dose	dose	NOUN
admet-829	133	34	in	in	ADP
admet-829	133	35	each	each	DET
admet-829	133	36	plug	plug	NOUN
admet-829	133	37	from	from	ADP
admet-829	133	38	one	one	NUM
admet-829	133	39	third	third	NOUN
admet-829	133	40	of	of	ADP
admet-829	133	41	the	the	DET
admet-829	133	42	total	total	NOUN
admet-829	133	43	dose	dose	NOUN
admet-829	133	44	to	to	ADP
admet-829	133	45	one	one	NUM
admet-829	133	46	seventh	seventh	NOUN
admet-829	133	47	.	.	PUNCT
admet-829	134	1	the	the	DET
admet-829	134	2	total	total	ADJ
admet-829	134	3	plasma	plasma	NOUN
admet-829	134	4	concentration	concentration	NOUN
admet-829	134	5	profiles	profile	NOUN
admet-829	134	6	from	from	ADP
admet-829	134	7	the	the	DET
admet-829	134	8	two	two	NUM
admet-829	134	9	simulations	simulation	NOUN
admet-829	134	10	were	be	AUX
admet-829	134	11	not	not	PART
admet-829	134	12	substantially	substantially	ADV
admet-829	134	13	different	different	ADJ
admet-829	134	14	,	,	PUNCT
admet-829	134	15	indicating	indicate	VERB
admet-829	134	16	that	that	SCONJ
admet-829	134	17	there	there	PRON
admet-829	134	18	is	be	VERB
admet-829	134	19	potential	potential	ADJ
admet-829	134	20	to	to	PART
admet-829	134	21	reduce	reduce	VERB
admet-829	134	22	the	the	DET
admet-829	134	23	number	number	NOUN
admet-829	134	24	of	of	ADP
admet-829	134	25	plugs	plug	NOUN
admet-829	134	26	without	without	ADP
admet-829	134	27	changing	change	VERB
admet-829	134	28	the	the	DET
admet-829	134	29	simulation	simulation	NOUN
admet-829	134	30	significantly	significantly	ADV
admet-829	134	31	.	.	PUNCT
admet-829	135	1	the	the	DET
admet-829	135	2	number	number	NOUN
admet-829	135	3	of	of	ADP
admet-829	135	4	plugs	plug	NOUN
admet-829	135	5	used	use	VERB
admet-829	135	6	in	in	ADP
admet-829	135	7	the	the	DET
admet-829	135	8	mmp	mmp	PROPN
admet-829	135	9	should	should	AUX
admet-829	135	10	be	be	AUX
admet-829	135	11	no	no	ADV
admet-829	135	12	more	more	ADJ
admet-829	135	13	than	than	ADP
admet-829	135	14	the	the	DET
admet-829	135	15	number	number	NOUN
admet-829	135	16	observed	observe	VERB
admet-829	135	17	experimentally	experimentally	ADV
admet-829	135	18	and	and	CCONJ
admet-829	135	19	potentially	potentially	ADV
admet-829	135	20	only	only	ADV
admet-829	135	21	a	a	DET
admet-829	135	22	fraction	fraction	NOUN
admet-829	135	23	thereof	thereof	ADV
admet-829	135	24	.	.	PUNCT
admet-829	136	1	the	the	DET
admet-829	136	2	summation	summation	NOUN
admet-829	136	3	technique	technique	NOUN
admet-829	136	4	of	of	ADP
admet-829	136	5	the	the	DET
admet-829	136	6	mmp	mmp	PROPN
admet-829	136	7	model	model	NOUN
admet-829	136	8	is	be	AUX
admet-829	136	9	similar	similar	ADJ
admet-829	136	10	to	to	ADP
admet-829	136	11	the	the	DET
admet-829	136	12	superposition	superposition	NOUN
admet-829	136	13	principle	principle	NOUN
admet-829	136	14	,	,	PUNCT
admet-829	136	15	except	except	SCONJ
admet-829	136	16	that	that	SCONJ
admet-829	136	17	the	the	DET
admet-829	136	18	summation	summation	NOUN
admet-829	136	19	occurs	occur	VERB
admet-829	136	20	at	at	ADP
admet-829	136	21	each	each	DET
admet-829	136	22	step	step	NOUN
admet-829	136	23	of	of	ADP
admet-829	136	24	the	the	DET
admet-829	136	25	numerical	numerical	ADJ
admet-829	136	26	method	method	NOUN
admet-829	136	27	,	,	PUNCT
admet-829	136	28	as	as	SCONJ
admet-829	136	29	opposed	oppose	VERB
admet-829	136	30	to	to	ADP
admet-829	136	31	summing	sum	VERB
admet-829	136	32	the	the	DET
admet-829	136	33	contributions	contribution	NOUN
admet-829	136	34	after	after	SCONJ
admet-829	136	35	all	all	DET
admet-829	136	36	plugs	plug	NOUN
admet-829	136	37	have	have	AUX
admet-829	136	38	been	be	AUX
admet-829	136	39	simulated	simulate	VERB
admet-829	136	40	.	.	PUNCT
admet-829	137	1	this	this	DET
admet-829	137	2	treatment	treatment	NOUN
admet-829	137	3	allows	allow	VERB
admet-829	137	4	the	the	DET
admet-829	137	5	mmp	mmp	PROPN
admet-829	137	6	model	model	NOUN
admet-829	137	7	to	to	PART
admet-829	137	8	handle	handle	VERB
admet-829	137	9	non	non	ADJ
admet-829	137	10	-	-	ADJ
admet-829	137	11	linear	linear	ADJ
admet-829	137	12	pharmacokinetics	pharmacokinetic	NOUN
admet-829	137	13	.	.	PUNCT
admet-829	138	1	different	different	ADJ
admet-829	138	2	metabolic	metabolic	NOUN
admet-829	138	3	rates	rate	NOUN
admet-829	138	4	can	can	AUX
admet-829	138	5	be	be	AUX
admet-829	138	6	tied	tie	VERB
admet-829	138	7	to	to	ADP
admet-829	138	8	the	the	DET
admet-829	138	9	continuously	continuously	ADV
admet-829	138	10	updated	update	VERB
admet-829	138	11	drug	drug	NOUN
admet-829	138	12	mass	mass	NOUN
admet-829	138	13	in	in	ADP
admet-829	138	14	different	different	ADJ
admet-829	138	15	admet	admet	PROPN
admet-829	138	16	&	&	CCONJ
admet-829	138	17	dmpk	dmpk	PROPN
admet-829	138	18	8(3	8(3	NUM
admet-829	138	19	)	)	PUNCT
admet-829	138	20	(	(	PUNCT
admet-829	138	21	2020	2020	NUM
admet-829	138	22	)	)	PUNCT
admet-829	138	23	314	314	NUM
admet-829	138	24	-	-	SYM
admet-829	138	25	324	324	NUM
admet-829	138	26	mechanistic	mechanistic	ADJ
admet-829	138	27	modeling	modeling	NOUN
admet-829	138	28	of	of	ADP
admet-829	138	29	gastrointestinal	gastrointestinal	ADJ
admet-829	138	30	motility	motility	NOUN
admet-829	138	31	doi	doi	NOUN
admet-829	138	32	:	:	PUNCT
admet-829	138	33	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	NOUN
admet-829	138	34	321	321	NUM
admet-829	138	35	locations	location	NOUN
admet-829	138	36	:	:	PUNCT
admet-829	138	37	the	the	DET
admet-829	138	38	intestine	intestine	NOUN
admet-829	138	39	for	for	ADP
admet-829	138	40	gut	gut	NOUN
admet-829	138	41	wall	wall	NOUN
admet-829	138	42	metabolism	metabolism	NOUN
admet-829	138	43	,	,	PUNCT
admet-829	138	44	the	the	DET
admet-829	138	45	portal	portal	NOUN
admet-829	138	46	vein	vein	VERB
admet-829	138	47	for	for	ADP
admet-829	138	48	first	first	ADJ
admet-829	138	49	-	-	PUNCT
admet-829	138	50	pass	pass	VERB
admet-829	138	51	hepatic	hepatic	ADJ
admet-829	138	52	metabolism	metabolism	NOUN
admet-829	138	53	,	,	PUNCT
admet-829	138	54	or	or	CCONJ
admet-829	138	55	the	the	DET
admet-829	138	56	plasma	plasma	NOUN
admet-829	138	57	compartment	compartment	NOUN
admet-829	138	58	for	for	ADP
admet-829	138	59	renal	renal	ADJ
admet-829	138	60	clearance	clearance	NOUN
admet-829	138	61	.	.	PUNCT
admet-829	139	1	the	the	DET
admet-829	139	2	pharmacokinetic	pharmacokinetic	ADJ
admet-829	139	3	model	model	NOUN
admet-829	139	4	described	describe	VERB
admet-829	139	5	in	in	ADP
admet-829	139	6	table	table	NOUN
admet-829	139	7	1	1	NUM
admet-829	139	8	would	would	AUX
admet-829	139	9	have	have	VERB
admet-829	139	10	to	to	PART
admet-829	139	11	be	be	AUX
admet-829	139	12	expanded	expand	VERB
admet-829	139	13	to	to	PART
admet-829	139	14	allow	allow	VERB
admet-829	139	15	for	for	ADP
admet-829	139	16	the	the	DET
admet-829	139	17	simulation	simulation	NOUN
admet-829	139	18	of	of	ADP
admet-829	139	19	portal	portal	ADJ
admet-829	139	20	vein	vein	ADJ
admet-829	139	21	drug	drug	NOUN
admet-829	139	22	concentrations	concentration	NOUN
admet-829	139	23	.	.	PUNCT
admet-829	140	1	figure	figure	VERB
admet-829	140	2	6	6	NUM
admet-829	140	3	.	.	PUNCT
admet-829	140	4	simulated	simulate	VERB
admet-829	140	5	plasma	plasma	NOUN
admet-829	140	6	drug	drug	NOUN
admet-829	140	7	concentration	concentration	NOUN
admet-829	140	8	from	from	ADP
admet-829	140	9	figure	figure	NOUN
admet-829	140	10	2	2	NUM
admet-829	140	11	(	(	PUNCT
admet-829	140	12	red	red	NOUN
admet-829	140	13	)	)	PUNCT
admet-829	140	14	compared	compare	VERB
admet-829	140	15	to	to	ADP
admet-829	140	16	a	a	DET
admet-829	140	17	new	new	ADJ
admet-829	140	18	simulation	simulation	NOUN
admet-829	140	19	(	(	PUNCT
admet-829	140	20	black	black	NOUN
admet-829	140	21	)	)	PUNCT
admet-829	140	22	except	except	SCONJ
admet-829	140	23	that	that	SCONJ
admet-829	140	24	the	the	DET
admet-829	140	25	new	new	ADJ
admet-829	140	26	simulation	simulation	NOUN
admet-829	140	27	used	use	VERB
admet-829	140	28	7	7	NUM
admet-829	140	29	plugs	plug	NOUN
admet-829	140	30	instead	instead	ADV
admet-829	140	31	of	of	ADP
admet-829	140	32	3	3	NUM
admet-829	140	33	,	,	PUNCT
admet-829	140	34	and	and	CCONJ
admet-829	140	35	the	the	DET
admet-829	140	36	total	total	ADJ
admet-829	140	37	dose	dose	NOUN
admet-829	140	38	was	be	AUX
admet-829	140	39	divided	divide	VERB
admet-829	140	40	evenly	evenly	ADV
admet-829	140	41	between	between	ADP
admet-829	140	42	7	7	NUM
admet-829	140	43	plugs	plug	NOUN
admet-829	140	44	instead	instead	ADV
admet-829	140	45	of	of	ADP
admet-829	140	46	3	3	NUM
admet-829	140	47	.	.	PUNCT
admet-829	141	1	the	the	DET
admet-829	141	2	heavier	heavy	ADJ
admet-829	141	3	lines	line	NOUN
admet-829	141	4	represent	represent	VERB
admet-829	141	5	summations	summation	NOUN
admet-829	141	6	from	from	ADP
admet-829	141	7	the	the	DET
admet-829	141	8	lighter	light	ADJ
admet-829	141	9	individual	individual	ADJ
admet-829	141	10	plug	plug	NOUN
admet-829	141	11	lines	line	NOUN
admet-829	141	12	.	.	PUNCT
admet-829	142	1	the	the	DET
admet-829	142	2	advantage	advantage	NOUN
admet-829	142	3	of	of	ADP
admet-829	142	4	the	the	DET
admet-829	142	5	mmp	mmp	PROPN
admet-829	142	6	model	model	NOUN
admet-829	142	7	is	be	AUX
admet-829	142	8	that	that	SCONJ
admet-829	142	9	it	it	PRON
admet-829	142	10	provides	provide	VERB
admet-829	142	11	a	a	DET
admet-829	142	12	more	more	ADV
admet-829	142	13	realistic	realistic	ADJ
admet-829	142	14	computational	computational	ADJ
admet-829	142	15	approach	approach	NOUN
admet-829	142	16	to	to	ADP
admet-829	142	17	simulating	simulate	VERB
admet-829	142	18	gastric	gastric	ADJ
admet-829	142	19	emptying	empty	VERB
admet-829	142	20	and	and	CCONJ
admet-829	142	21	gi	gi	NOUN
admet-829	142	22	motility	motility	NOUN
admet-829	142	23	compared	compare	VERB
admet-829	142	24	to	to	ADP
admet-829	142	25	the	the	DET
admet-829	142	26	advanced	advanced	ADJ
admet-829	142	27	compartmental	compartmental	ADJ
admet-829	142	28	absorption	absorption	NOUN
admet-829	142	29	and	and	CCONJ
admet-829	142	30	transit	transit	NOUN
admet-829	142	31	(	(	PUNCT
admet-829	142	32	acat	acat	ADJ
admet-829	142	33	)	)	PUNCT
admet-829	142	34	model	model	NOUN
admet-829	142	35	.	.	PUNCT
admet-829	143	1	historically	historically	ADV
admet-829	143	2	,	,	PUNCT
admet-829	143	3	the	the	DET
admet-829	143	4	acat	acat	PROPN
admet-829	143	5	model	model	NOUN
admet-829	143	6	has	have	AUX
admet-829	143	7	assumed	assume	VERB
admet-829	143	8	that	that	SCONJ
admet-829	143	9	both	both	CCONJ
admet-829	143	10	solid	solid	ADJ
admet-829	143	11	and	and	CCONJ
admet-829	143	12	dissolved	dissolve	VERB
admet-829	143	13	drug	drug	NOUN
admet-829	143	14	move	move	NOUN
admet-829	143	15	from	from	ADP
admet-829	143	16	compartment	compartment	NOUN
admet-829	143	17	to	to	ADP
admet-829	143	18	compartment	compartment	NOUN
admet-829	143	19	in	in	ADP
admet-829	143	20	a	a	DET
admet-829	143	21	first	first	ADJ
admet-829	143	22	-	-	PUNCT
admet-829	143	23	order	order	NOUN
admet-829	143	24	process	process	NOUN
admet-829	143	25	without	without	ADP
admet-829	143	26	any	any	DET
admet-829	143	27	concomitant	concomitant	ADJ
admet-829	143	28	movement	movement	NOUN
admet-829	143	29	of	of	ADP
admet-829	143	30	compartmental	compartmental	ADJ
admet-829	143	31	fluid	fluid	NOUN
admet-829	143	32	,	,	PUNCT
admet-829	143	33	which	which	PRON
admet-829	143	34	remains	remain	VERB
admet-829	143	35	static	static	ADJ
admet-829	143	36	in	in	ADP
admet-829	143	37	terms	term	NOUN
admet-829	143	38	of	of	ADP
admet-829	143	39	both	both	DET
admet-829	143	40	position	position	NOUN
admet-829	143	41	and	and	CCONJ
admet-829	143	42	volume	volume	NOUN
admet-829	143	43	[	[	X
admet-829	143	44	14	14	NUM
admet-829	143	45	]	]	PUNCT
admet-829	143	46	.	.	PUNCT
admet-829	144	1	these	these	DET
admet-829	144	2	assumptions	assumption	NOUN
admet-829	144	3	are	be	AUX
admet-829	144	4	inconsistent	inconsistent	ADJ
admet-829	144	5	with	with	ADP
admet-829	144	6	physical	physical	ADJ
admet-829	144	7	observations	observation	NOUN
admet-829	144	8	and	and	CCONJ
admet-829	144	9	can	can	AUX
admet-829	144	10	not	not	PART
admet-829	144	11	be	be	AUX
admet-829	144	12	replicated	replicate	VERB
admet-829	144	13	experimentally	experimentally	ADV
admet-829	144	14	.	.	PUNCT
admet-829	145	1	indeed	indeed	ADV
admet-829	145	2	,	,	PUNCT
admet-829	145	3	the	the	DET
admet-829	145	4	development	development	NOUN
admet-829	145	5	of	of	ADP
admet-829	145	6	dissolution	dissolution	NOUN
admet-829	145	7	testing	testing	NOUN
admet-829	145	8	apparatus	apparatus	NOUN
admet-829	145	9	involving	involve	VERB
admet-829	145	10	more	more	ADJ
admet-829	145	11	than	than	ADP
admet-829	145	12	one	one	NUM
admet-829	145	13	dissolution	dissolution	NOUN
admet-829	145	14	vessels	vessel	NOUN
admet-829	145	15	to	to	PART
admet-829	145	16	mimic	mimic	VERB
admet-829	145	17	the	the	DET
admet-829	145	18	stomach	stomach	NOUN
admet-829	145	19	and	and	CCONJ
admet-829	145	20	segments	segment	NOUN
admet-829	145	21	of	of	ADP
admet-829	145	22	the	the	DET
admet-829	145	23	small	small	ADJ
admet-829	145	24	intestine	intestine	NOUN
admet-829	145	25	rely	rely	VERB
admet-829	145	26	on	on	ADP
admet-829	145	27	the	the	DET
admet-829	145	28	concomitant	concomitant	ADJ
admet-829	145	29	movement	movement	NOUN
admet-829	145	30	of	of	ADP
admet-829	145	31	water	water	NOUN
admet-829	145	32	and	and	CCONJ
admet-829	145	33	solid	solid	ADJ
admet-829	145	34	and	and	CCONJ
admet-829	145	35	dissolved	dissolve	VERB
admet-829	145	36	drug	drug	NOUN
admet-829	145	37	[	[	X
admet-829	145	38	15	15	NUM
admet-829	145	39	]	]	PUNCT
admet-829	145	40	.	.	PUNCT
admet-829	146	1	ehrlein	ehrlein	PROPN
admet-829	146	2	and	and	CCONJ
admet-829	146	3	schemann	schemann	NOUN
admet-829	147	1	[	[	X
admet-829	147	2	16	16	NUM
admet-829	147	3	]	]	PUNCT
admet-829	147	4	have	have	AUX
admet-829	147	5	created	create	VERB
admet-829	147	6	a	a	DET
admet-829	147	7	website	website	NOUN
admet-829	147	8	with	with	ADP
admet-829	147	9	links	link	NOUN
admet-829	147	10	to	to	ADP
admet-829	147	11	videos	video	NOUN
admet-829	147	12	using	use	VERB
admet-829	147	13	fluoroscopy	fluoroscopy	NOUN
admet-829	147	14	that	that	PRON
admet-829	147	15	provide	provide	VERB
admet-829	147	16	visual	visual	ADJ
admet-829	147	17	confirmation	confirmation	NOUN
admet-829	147	18	of	of	ADP
admet-829	147	19	the	the	DET
admet-829	147	20	true	true	ADJ
admet-829	147	21	nature	nature	NOUN
admet-829	147	22	of	of	ADP
admet-829	147	23	gi	gi	NOUN
admet-829	147	24	motility	motility	NOUN
admet-829	147	25	.	.	PUNCT
admet-829	148	1	the	the	DET
admet-829	148	2	other	other	ADJ
admet-829	148	3	advantage	advantage	NOUN
admet-829	148	4	of	of	ADP
admet-829	148	5	the	the	DET
admet-829	148	6	mmp	mmp	PROPN
admet-829	148	7	model	model	NOUN
admet-829	148	8	is	be	AUX
admet-829	148	9	that	that	SCONJ
admet-829	148	10	all	all	DET
admet-829	148	11	processes	process	NOUN
admet-829	148	12	are	be	AUX
admet-829	148	13	modeled	model	VERB
admet-829	148	14	from	from	ADP
admet-829	148	15	the	the	DET
admet-829	148	16	perspective	perspective	NOUN
admet-829	148	17	of	of	ADP
admet-829	148	18	isolated	isolated	ADJ
admet-829	148	19	plugs	plug	NOUN
admet-829	148	20	of	of	ADP
admet-829	148	21	moving	move	VERB
admet-829	148	22	fluid	fluid	NOUN
admet-829	148	23	,	,	PUNCT
admet-829	148	24	making	make	VERB
admet-829	148	25	experimental	experimental	ADJ
admet-829	148	26	validation	validation	NOUN
admet-829	148	27	of	of	ADP
admet-829	148	28	the	the	DET
admet-829	148	29	model	model	NOUN
admet-829	148	30	components	component	NOUN
admet-829	148	31	possible	possible	ADJ
admet-829	148	32	.	.	PUNCT
admet-829	149	1	for	for	ADP
admet-829	149	2	example	example	NOUN
admet-829	149	3	,	,	PUNCT
admet-829	149	4	it	it	PRON
admet-829	149	5	has	have	AUX
admet-829	149	6	already	already	ADV
admet-829	149	7	been	be	AUX
admet-829	149	8	mentioned	mention	VERB
admet-829	149	9	that	that	SCONJ
admet-829	149	10	the	the	DET
admet-829	149	11	dissolution	dissolution	ADJ
admet-829	149	12	component	component	NOUN
admet-829	149	13	of	of	ADP
admet-829	149	14	the	the	DET
admet-829	149	15	mmp	mmp	PROPN
admet-829	149	16	model	model	NOUN
admet-829	149	17	has	have	AUX
admet-829	149	18	been	be	AUX
admet-829	149	19	established	establish	VERB
admet-829	149	20	[	[	PUNCT
admet-829	149	21	7,8	7,8	NUM
admet-829	149	22	]	]	PUNCT
admet-829	149	23	and	and	CCONJ
admet-829	149	24	independently	independently	ADV
admet-829	149	25	verified	verify	VERB
admet-829	149	26	[	[	PUNCT
admet-829	149	27	9	9	NUM
admet-829	149	28	]	]	PUNCT
admet-829	149	29	for	for	ADP
admet-829	149	30	a	a	DET
admet-829	149	31	constant	constant	ADJ
admet-829	149	32	volume	volume	NOUN
admet-829	149	33	of	of	ADP
admet-829	149	34	fluid	fluid	NOUN
admet-829	149	35	.	.	PUNCT
admet-829	150	1	however	however	ADV
admet-829	150	2	,	,	PUNCT
admet-829	150	3	in	in	ADP
admet-829	150	4	vivo	vivo	NOUN
admet-829	150	5	,	,	PUNCT
admet-829	150	6	the	the	DET
admet-829	150	7	volume	volume	NOUN
admet-829	150	8	of	of	ADP
admet-829	150	9	the	the	DET
admet-829	150	10	dissolution	dissolution	NOUN
admet-829	150	11	fluid	fluid	NOUN
admet-829	150	12	will	will	AUX
admet-829	150	13	change	change	VERB
admet-829	150	14	;	;	PUNCT
admet-829	150	15	increasing	increase	VERB
admet-829	150	16	due	due	ADP
admet-829	150	17	to	to	ADP
admet-829	150	18	secretion	secretion	NOUN
admet-829	150	19	of	of	ADP
admet-829	150	20	fluids	fluid	NOUN
admet-829	150	21	or	or	CCONJ
admet-829	150	22	decreasing	decrease	VERB
admet-829	150	23	due	due	ADJ
admet-829	150	24	to	to	ADP
admet-829	150	25	water	water	NOUN
admet-829	150	26	absorption	absorption	NOUN
admet-829	150	27	.	.	PUNCT
admet-829	151	1	testing	testing	NOUN
admet-829	151	2	of	of	ADP
admet-829	151	3	the	the	DET
admet-829	151	4	dissolution	dissolution	NOUN
admet-829	151	5	model	model	NOUN
admet-829	151	6	to	to	PART
admet-829	151	7	simulate	simulate	VERB
admet-829	151	8	secretion	secretion	NOUN
admet-829	151	9	can	can	AUX
admet-829	151	10	be	be	AUX
admet-829	151	11	accomplished	accomplish	VERB
admet-829	151	12	by	by	ADP
admet-829	151	13	adding	add	VERB
admet-829	151	14	fluid	fluid	NOUN
admet-829	151	15	to	to	ADP
admet-829	151	16	the	the	DET
admet-829	151	17	dissolution	dissolution	NOUN
admet-829	151	18	vessel	vessel	NOUN
admet-829	151	19	at	at	ADP
admet-829	151	20	a	a	DET
admet-829	151	21	known	know	VERB
admet-829	151	22	rate	rate	NOUN
admet-829	151	23	.	.	PUNCT
admet-829	152	1	on	on	ADP
admet-829	152	2	the	the	DET
admet-829	152	3	other	other	ADJ
admet-829	152	4	hand	hand	NOUN
admet-829	152	5	,	,	PUNCT
admet-829	152	6	removing	remove	VERB
admet-829	152	7	fluid	fluid	NOUN
admet-829	152	8	to	to	PART
admet-829	152	9	simulate	simulate	VERB
admet-829	152	10	water	water	NOUN
admet-829	152	11	absorption	absorption	NOUN
admet-829	152	12	is	be	AUX
admet-829	152	13	more	more	ADV
admet-829	152	14	difficult	difficult	ADJ
admet-829	152	15	.	.	PUNCT
admet-829	153	1	evaporation	evaporation	NOUN
admet-829	153	2	is	be	AUX
admet-829	153	3	probably	probably	ADV
admet-829	153	4	not	not	PART
admet-829	153	5	fast	fast	ADJ
admet-829	153	6	enough	enough	ADV
admet-829	153	7	to	to	PART
admet-829	153	8	mimic	mimic	VERB
admet-829	153	9	the	the	DET
admet-829	153	10	rate	rate	NOUN
admet-829	153	11	of	of	ADP
admet-829	153	12	water	water	NOUN
admet-829	153	13	absorption	absorption	NOUN
admet-829	153	14	from	from	ADP
admet-829	153	15	the	the	DET
admet-829	153	16	gi	gi	NOUN
admet-829	153	17	tract	tract	NOUN
admet-829	153	18	,	,	PUNCT
admet-829	153	19	but	but	CCONJ
admet-829	153	20	could	could	AUX
admet-829	153	21	be	be	AUX
admet-829	153	22	used	use	VERB
admet-829	153	23	to	to	PART
admet-829	153	24	test	test	VERB
admet-829	153	25	the	the	DET
admet-829	153	26	dissolution	dissolution	NOUN
admet-829	153	27	model	model	NOUN
admet-829	153	28	over	over	ADP
admet-829	153	29	a	a	DET
admet-829	153	30	narrow	narrow	ADJ
admet-829	153	31	range	range	NOUN
admet-829	153	32	.	.	PUNCT
admet-829	154	1	there	there	PRON
admet-829	154	2	is	be	VERB
admet-829	154	3	no	no	DET
admet-829	154	4	reason	reason	NOUN
admet-829	154	5	to	to	PART
admet-829	154	6	believe	believe	VERB
admet-829	154	7	that	that	SCONJ
admet-829	154	8	the	the	DET
admet-829	154	9	principles	principle	NOUN
admet-829	154	10	of	of	ADP
admet-829	154	11	the	the	DET
admet-829	154	12	mechanistic	mechanistic	ADJ
admet-829	154	13	dissolution	dissolution	NOUN
admet-829	154	14	model	model	NOUN
admet-829	154	15	should	should	AUX
admet-829	154	16	fail	fail	VERB
admet-829	154	17	in	in	ADP
admet-829	154	18	extrapolating	extrapolate	VERB
admet-829	154	19	to	to	ADP
admet-829	154	20	higher	high	ADJ
admet-829	154	21	rates	rate	NOUN
admet-829	154	22	of	of	ADP
admet-829	154	23	water	water	NOUN
admet-829	154	24	removal	removal	NOUN
admet-829	154	25	.	.	PUNCT
admet-829	155	1	moreover	moreover	ADV
admet-829	155	2	,	,	PUNCT
admet-829	155	3	there	there	PRON
admet-829	155	4	is	be	VERB
admet-829	155	5	a	a	DET
admet-829	155	6	need	need	NOUN
admet-829	155	7	to	to	PART
admet-829	155	8	simulate	simulate	VERB
admet-829	155	9	the	the	DET
admet-829	155	10	effect	effect	NOUN
admet-829	155	11	of	of	ADP
admet-829	155	12	water	water	NOUN
admet-829	155	13	absorption	absorption	NOUN
admet-829	155	14	on	on	ADP
admet-829	155	15	drug	drug	NOUN
admet-829	155	16	dissolution	dissolution	NOUN
admet-829	155	17	and	and	CCONJ
admet-829	155	18	absorption	absorption	NOUN
admet-829	155	19	as	as	ADP
admet-829	155	20	the	the	DET
admet-829	155	21	reduction	reduction	NOUN
admet-829	155	22	in	in	ADP
admet-829	155	23	water	water	NOUN
admet-829	155	24	volume	volume	NOUN
admet-829	155	25	in	in	ADP
admet-829	155	26	the	the	DET
admet-829	155	27	gi	gi	NOUN
admet-829	155	28	tract	tract	NOUN
admet-829	155	29	after	after	SCONJ
admet-829	155	30	dosing	dose	VERB
admet-829	155	31	has	have	AUX
admet-829	155	32	been	be	AUX
admet-829	155	33	clearly	clearly	ADV
admet-829	155	34	shown	show	VERB
admet-829	155	35	by	by	ADP
admet-829	155	36	mudie	mudie	PROPN
admet-829	155	37	et	et	PROPN
admet-829	155	38	al	al	PROPN
admet-829	155	39	.	.	PUNCT
admet-829	156	1	[	[	X
admet-829	156	2	4	4	X
admet-829	156	3	]	]	PUNCT
admet-829	156	4	in	in	ADP
admet-829	156	5	either	either	DET
admet-829	156	6	case	case	NOUN
admet-829	156	7	,	,	PUNCT
admet-829	156	8	water	water	NOUN
admet-829	156	9	secretion	secretion	NOUN
admet-829	156	10	or	or	CCONJ
admet-829	156	11	absorption	absorption	NOUN
admet-829	156	12	,	,	PUNCT
admet-829	156	13	the	the	DET
admet-829	156	14	volume	volume	NOUN
admet-829	156	15	change	change	NOUN
admet-829	156	16	in	in	ADP
admet-829	156	17	a	a	DET
admet-829	156	18	dissolution	dissolution	ADJ
admet-829	156	19	vessel	vessel	NOUN
admet-829	156	20	can	can	AUX
admet-829	156	21	be	be	AUX
admet-829	156	22	measured	measure	VERB
admet-829	156	23	and	and	CCONJ
admet-829	156	24	corrected	correct	VERB
admet-829	156	25	at	at	ADP
admet-829	156	26	each	each	DET
admet-829	156	27	step	step	NOUN
admet-829	156	28	of	of	ADP
admet-829	156	29	the	the	DET
admet-829	156	30	numerical	numerical	PROPN
admet-829	156	31	simulation	simulation	PROPN
admet-829	156	32	.	.	PUNCT
admet-829	157	1	the	the	DET
admet-829	157	2	dissolution	dissolution	ADJ
admet-829	157	3	fluid	fluid	NOUN
admet-829	157	4	could	could	AUX
admet-829	157	5	also	also	ADV
admet-829	157	6	be	be	AUX
admet-829	157	7	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	157	8	kevin	kevin	PROPN
admet-829	157	9	c.	c.	PROPN
admet-829	157	10	johnson	johnson	PROPN
admet-829	157	11	admet	admet	PROPN
admet-829	157	12	&	&	CCONJ
admet-829	157	13	dmpk	dmpk	PROPN
admet-829	157	14	8(3	8(3	NUM
admet-829	157	15	)	)	PUNCT
admet-829	157	16	(	(	PUNCT
admet-829	157	17	2020	2020	NUM
admet-829	157	18	)	)	PUNCT
admet-829	157	19	314	314	NUM
admet-829	157	20	-	-	SYM
admet-829	157	21	324	324	NUM
admet-829	157	22	322	322	NUM
admet-829	157	23	titrated	titrate	VERB
admet-829	157	24	with	with	ADP
admet-829	157	25	physiological	physiological	ADJ
admet-829	157	26	buffers	buffer	NOUN
admet-829	157	27	,	,	PUNCT
admet-829	157	28	dynamically	dynamically	ADV
admet-829	157	29	adjusting	adjust	VERB
admet-829	157	30	the	the	DET
admet-829	157	31	ph	ph	ADJ
admet-829	157	32	-	-	ADJ
admet-829	157	33	dependent	dependent	ADJ
admet-829	157	34	solubility	solubility	NOUN
admet-829	157	35	and	and	CCONJ
admet-829	157	36	volume	volume	NOUN
admet-829	157	37	change	change	NOUN
admet-829	157	38	simultaneously	simultaneously	ADV
admet-829	157	39	.	.	PUNCT
admet-829	158	1	the	the	DET
admet-829	158	2	mmp	mmp	PROPN
admet-829	158	3	model	model	NOUN
admet-829	158	4	is	be	AUX
admet-829	158	5	completely	completely	ADV
admet-829	158	6	flexible	flexible	ADJ
admet-829	158	7	;	;	PUNCT
admet-829	158	8	any	any	DET
admet-829	158	9	number	number	NOUN
admet-829	158	10	of	of	ADP
admet-829	158	11	plugs	plug	NOUN
admet-829	158	12	containing	contain	VERB
admet-829	158	13	dissolving	dissolve	VERB
admet-829	158	14	drug	drug	NOUN
admet-829	158	15	can	can	AUX
admet-829	158	16	empty	empty	VERB
admet-829	158	17	from	from	ADP
admet-829	158	18	the	the	DET
admet-829	158	19	stomach	stomach	NOUN
admet-829	158	20	,	,	PUNCT
admet-829	158	21	each	each	PRON
admet-829	158	22	having	have	VERB
admet-829	158	23	a	a	DET
admet-829	158	24	volume	volume	NOUN
admet-829	158	25	and	and	CCONJ
admet-829	158	26	emptying	empty	VERB
admet-829	158	27	time	time	NOUN
admet-829	158	28	to	to	PART
admet-829	158	29	match	match	VERB
admet-829	158	30	experimental	experimental	ADJ
admet-829	158	31	measurements	measurement	NOUN
admet-829	158	32	.	.	PUNCT
admet-829	159	1	the	the	DET
admet-829	159	2	critical	critical	ADJ
admet-829	159	3	physiological	physiological	ADJ
admet-829	159	4	parameters	parameter	NOUN
admet-829	159	5	are	be	AUX
admet-829	159	6	the	the	DET
admet-829	159	7	volume	volume	NOUN
admet-829	159	8	of	of	ADP
admet-829	159	9	the	the	DET
admet-829	159	10	plugs	plug	NOUN
admet-829	159	11	,	,	PUNCT
admet-829	159	12	the	the	DET
admet-829	159	13	timing	timing	NOUN
admet-829	159	14	of	of	ADP
admet-829	159	15	their	their	PRON
admet-829	159	16	emptying	emptying	NOUN
admet-829	159	17	,	,	PUNCT
admet-829	159	18	and	and	CCONJ
admet-829	159	19	their	their	PRON
admet-829	159	20	residence	residence	NOUN
admet-829	159	21	time	time	NOUN
admet-829	159	22	in	in	ADP
admet-829	159	23	various	various	ADJ
admet-829	159	24	segments	segment	NOUN
admet-829	159	25	of	of	ADP
admet-829	159	26	the	the	DET
admet-829	159	27	intestinal	intestinal	ADJ
admet-829	159	28	tract	tract	NOUN
admet-829	159	29	.	.	PUNCT
admet-829	160	1	regional	regional	ADJ
admet-829	160	2	differences	difference	NOUN
admet-829	160	3	in	in	ADP
admet-829	160	4	permeability	permeability	NOUN
admet-829	160	5	and	and	CCONJ
admet-829	160	6	intestinal	intestinal	ADJ
admet-829	160	7	wall	wall	NOUN
admet-829	160	8	metabolism	metabolism	NOUN
admet-829	160	9	can	can	AUX
admet-829	160	10	be	be	AUX
admet-829	160	11	adjusted	adjust	VERB
admet-829	160	12	to	to	PART
admet-829	160	13	reflect	reflect	VERB
admet-829	160	14	the	the	DET
admet-829	160	15	current	current	ADJ
admet-829	160	16	position	position	NOUN
admet-829	160	17	of	of	ADP
admet-829	160	18	individual	individual	ADJ
admet-829	160	19	plugs	plug	NOUN
admet-829	160	20	.	.	PUNCT
admet-829	161	1	although	although	SCONJ
admet-829	161	2	the	the	DET
admet-829	161	3	simulations	simulation	NOUN
admet-829	161	4	shown	show	VERB
admet-829	161	5	in	in	ADP
admet-829	161	6	figures	figure	NOUN
admet-829	161	7	2	2	NUM
admet-829	161	8	-	-	SYM
admet-829	161	9	4	4	NUM
admet-829	161	10	were	be	AUX
admet-829	161	11	run	run	VERB
admet-829	161	12	with	with	ADP
admet-829	161	13	equally	equally	ADV
admet-829	161	14	spaced	spaced	ADJ
admet-829	161	15	plugs	plug	NOUN
admet-829	161	16	of	of	ADP
admet-829	161	17	the	the	DET
admet-829	161	18	same	same	ADJ
admet-829	161	19	volume	volume	NOUN
admet-829	161	20	to	to	PART
admet-829	161	21	demonstrate	demonstrate	VERB
admet-829	161	22	the	the	DET
admet-829	161	23	model	model	NOUN
admet-829	161	24	,	,	PUNCT
admet-829	161	25	using	use	VERB
admet-829	161	26	real	real	ADJ
admet-829	161	27	gastric	gastric	ADJ
admet-829	161	28	emptying	empty	VERB
admet-829	161	29	data	datum	NOUN
admet-829	161	30	will	will	AUX
admet-829	161	31	enable	enable	VERB
admet-829	161	32	more	more	ADV
admet-829	161	33	accurate	accurate	ADJ
admet-829	161	34	simulations	simulation	NOUN
admet-829	161	35	.	.	PUNCT
admet-829	162	1	the	the	DET
admet-829	162	2	mmp	mmp	PROPN
admet-829	162	3	model	model	NOUN
admet-829	162	4	assumes	assume	VERB
admet-829	162	5	that	that	SCONJ
admet-829	162	6	suspended	suspend	VERB
admet-829	162	7	and	and	CCONJ
admet-829	162	8	dissolved	dissolve	VERB
admet-829	162	9	drug	drug	NOUN
admet-829	162	10	are	be	AUX
admet-829	162	11	homogeneously	homogeneously	ADV
admet-829	162	12	mixed	mix	VERB
admet-829	162	13	within	within	ADP
admet-829	162	14	the	the	DET
admet-829	162	15	plug	plug	NOUN
admet-829	162	16	,	,	PUNCT
admet-829	162	17	and	and	CCONJ
admet-829	162	18	that	that	SCONJ
admet-829	162	19	only	only	ADV
admet-829	162	20	dissolved	dissolve	VERB
admet-829	162	21	drug	drug	NOUN
admet-829	162	22	can	can	AUX
admet-829	162	23	leave	leave	VERB
admet-829	162	24	the	the	DET
admet-829	162	25	plug	plug	NOUN
admet-829	162	26	through	through	ADP
admet-829	162	27	permeation	permeation	NOUN
admet-829	162	28	of	of	ADP
admet-829	162	29	the	the	DET
admet-829	162	30	intestinal	intestinal	ADJ
admet-829	162	31	membrane	membrane	NOUN
admet-829	162	32	.	.	PUNCT
admet-829	163	1	there	there	PRON
admet-829	163	2	is	be	VERB
admet-829	163	3	no	no	DET
admet-829	163	4	mass	mass	NOUN
admet-829	163	5	transfer	transfer	NOUN
admet-829	163	6	between	between	ADP
admet-829	163	7	plugs	plug	NOUN
admet-829	163	8	,	,	PUNCT
admet-829	163	9	but	but	CCONJ
admet-829	163	10	plugs	plug	NOUN
admet-829	163	11	could	could	AUX
admet-829	163	12	be	be	AUX
admet-829	163	13	made	make	VERB
admet-829	163	14	to	to	PART
admet-829	163	15	converge	converge	VERB
admet-829	163	16	or	or	CCONJ
admet-829	163	17	diverge	diverge	VERB
admet-829	163	18	by	by	ADP
admet-829	163	19	manipulating	manipulate	VERB
admet-829	163	20	the	the	DET
admet-829	163	21	time	time	NOUN
admet-829	163	22	-	-	PUNCT
admet-829	163	23	dependent	dependent	ADJ
admet-829	163	24	parameters	parameter	NOUN
admet-829	163	25	.	.	PUNCT
admet-829	164	1	it	it	PRON
admet-829	164	2	would	would	AUX
admet-829	164	3	also	also	ADV
admet-829	164	4	be	be	AUX
admet-829	164	5	possible	possible	ADJ
admet-829	164	6	to	to	PART
admet-829	164	7	break	break	VERB
admet-829	164	8	up	up	ADP
admet-829	164	9	a	a	DET
admet-829	164	10	large	large	ADJ
admet-829	164	11	volume	volume	NOUN
admet-829	164	12	of	of	ADP
admet-829	164	13	fluid	fluid	NOUN
admet-829	164	14	into	into	ADP
admet-829	164	15	several	several	ADJ
admet-829	164	16	smaller	small	ADJ
admet-829	164	17	plugs	plug	NOUN
admet-829	164	18	in	in	ADP
admet-829	164	19	order	order	NOUN
admet-829	164	20	to	to	PART
admet-829	164	21	simulate	simulate	VERB
admet-829	164	22	a	a	DET
admet-829	164	23	stepwise	stepwise	ADJ
admet-829	164	24	concentration	concentration	NOUN
admet-829	164	25	gradient	gradient	NOUN
admet-829	164	26	axially	axially	ADV
admet-829	164	27	from	from	ADP
admet-829	164	28	the	the	DET
admet-829	164	29	leading	leading	NOUN
admet-829	164	30	to	to	ADP
admet-829	164	31	the	the	DET
admet-829	164	32	trailing	trailing	NOUN
admet-829	164	33	end	end	NOUN
admet-829	164	34	of	of	ADP
admet-829	164	35	the	the	DET
admet-829	164	36	plug	plug	NOUN
admet-829	164	37	series	series	NOUN
admet-829	164	38	.	.	PUNCT
admet-829	165	1	it	it	PRON
admet-829	165	2	has	have	AUX
admet-829	165	3	long	long	ADV
admet-829	165	4	been	be	AUX
admet-829	165	5	recognized	recognize	VERB
admet-829	165	6	that	that	SCONJ
admet-829	165	7	gastric	gastric	ADJ
admet-829	165	8	emptying	emptying	NOUN
admet-829	165	9	can	can	AUX
admet-829	165	10	affect	affect	VERB
admet-829	165	11	the	the	DET
admet-829	165	12	rate	rate	NOUN
admet-829	165	13	of	of	ADP
admet-829	165	14	drug	drug	NOUN
admet-829	165	15	absorption	absorption	NOUN
admet-829	166	1	[	[	X
admet-829	166	2	17,18	17,18	NUM
admet-829	166	3	]	]	PUNCT
admet-829	166	4	.	.	PUNCT
admet-829	167	1	this	this	DET
admet-829	167	2	rate	rate	NOUN
admet-829	167	3	,	,	PUNCT
admet-829	167	4	characterized	characterize	VERB
admet-829	167	5	by	by	ADP
admet-829	167	6	cmax	cmax	NOUN
admet-829	167	7	and	and	CCONJ
admet-829	167	8	tmax	tmax	ADV
admet-829	167	9	,	,	PUNCT
admet-829	167	10	is	be	AUX
admet-829	167	11	used	use	VERB
admet-829	167	12	to	to	PART
admet-829	167	13	establish	establish	VERB
admet-829	167	14	bioequivalence	bioequivalence	NOUN
admet-829	167	15	when	when	SCONJ
admet-829	167	16	considering	consider	VERB
admet-829	167	17	a	a	DET
admet-829	167	18	formulation	formulation	NOUN
admet-829	167	19	change	change	NOUN
admet-829	167	20	or	or	CCONJ
admet-829	167	21	when	when	SCONJ
admet-829	167	22	comparing	compare	VERB
admet-829	167	23	a	a	DET
admet-829	167	24	generic	generic	ADJ
admet-829	167	25	dosage	dosage	NOUN
admet-829	167	26	form	form	NOUN
admet-829	167	27	to	to	ADP
admet-829	167	28	an	an	DET
admet-829	167	29	innovator	innovator	NOUN
admet-829	167	30	’s	’s	PART
admet-829	167	31	product	product	NOUN
admet-829	167	32	.	.	PUNCT
admet-829	168	1	simulations	simulation	NOUN
admet-829	168	2	show	show	VERB
admet-829	168	3	that	that	SCONJ
admet-829	168	4	cmax	cmax	NOUN
admet-829	168	5	and	and	CCONJ
admet-829	168	6	tmax	tmax	ADV
admet-829	168	7	are	be	AUX
admet-829	168	8	sensitive	sensitive	ADJ
admet-829	168	9	to	to	ADP
admet-829	168	10	gastric	gastric	ADJ
admet-829	168	11	emptying	empty	VERB
admet-829	168	12	as	as	SCONJ
admet-829	168	13	modeled	model	VERB
admet-829	168	14	by	by	ADP
admet-829	168	15	the	the	DET
admet-829	168	16	mmp	mmp	PROPN
admet-829	168	17	model	model	NOUN
admet-829	168	18	.	.	PUNCT
admet-829	169	1	if	if	SCONJ
admet-829	169	2	the	the	DET
admet-829	169	3	bioequivalence	bioequivalence	NOUN
admet-829	169	4	criteria	criterion	NOUN
admet-829	169	5	are	be	AUX
admet-829	169	6	too	too	ADV
admet-829	169	7	tight	tight	ADJ
admet-829	169	8	,	,	PUNCT
admet-829	169	9	a	a	DET
admet-829	169	10	dosage	dosage	NOUN
admet-829	169	11	form	form	NOUN
admet-829	169	12	could	could	AUX
admet-829	169	13	fail	fail	VERB
admet-829	169	14	bioequivalence	bioequivalence	NOUN
admet-829	169	15	testing	testing	NOUN
admet-829	169	16	due	due	ADP
admet-829	169	17	to	to	ADP
admet-829	169	18	physiological	physiological	ADJ
admet-829	169	19	factors	factor	NOUN
admet-829	169	20	beyond	beyond	ADP
admet-829	169	21	the	the	DET
admet-829	169	22	control	control	NOUN
admet-829	169	23	of	of	ADP
admet-829	169	24	the	the	DET
admet-829	169	25	formulation	formulation	NOUN
admet-829	169	26	.	.	PUNCT
admet-829	170	1	to	to	PART
admet-829	170	2	address	address	VERB
admet-829	170	3	this	this	DET
admet-829	170	4	problem	problem	NOUN
admet-829	170	5	,	,	PUNCT
admet-829	170	6	dickinson	dickinson	PROPN
admet-829	170	7	et	et	PROPN
admet-829	170	8	al	al	PROPN
admet-829	170	9	.	.	PUNCT
admet-829	171	1	[	[	X
admet-829	171	2	19	19	NUM
admet-829	171	3	]	]	PUNCT
admet-829	171	4	have	have	AUX
admet-829	171	5	discussed	discuss	VERB
admet-829	171	6	the	the	DET
admet-829	171	7	concept	concept	NOUN
admet-829	171	8	of	of	ADP
admet-829	171	9	a	a	DET
admet-829	171	10	safe	safe	ADJ
admet-829	171	11	space	space	NOUN
admet-829	171	12	to	to	PART
admet-829	171	13	allow	allow	VERB
admet-829	171	14	for	for	ADP
admet-829	171	15	the	the	DET
admet-829	171	16	effect	effect	NOUN
admet-829	171	17	of	of	ADP
admet-829	171	18	physiological	physiological	ADJ
admet-829	171	19	factors	factor	NOUN
admet-829	171	20	like	like	ADP
admet-829	171	21	gastric	gastric	ADJ
admet-829	171	22	emptying	empty	VERB
admet-829	171	23	on	on	ADP
admet-829	171	24	the	the	DET
admet-829	171	25	bioequivalence	bioequivalence	NOUN
admet-829	171	26	criteria	criterion	NOUN
admet-829	171	27	.	.	PUNCT
admet-829	172	1	physiologically	physiologically	ADV
admet-829	172	2	based	base	VERB
admet-829	172	3	pharmacokinetic	pharmacokinetic	ADJ
admet-829	172	4	(	(	PUNCT
admet-829	172	5	pbpk	pbpk	NOUN
admet-829	172	6	)	)	PUNCT
admet-829	172	7	modeling	modeling	NOUN
admet-829	172	8	holds	hold	VERB
admet-829	172	9	promise	promise	NOUN
admet-829	172	10	for	for	ADP
admet-829	172	11	establishing	establish	VERB
admet-829	172	12	this	this	DET
admet-829	172	13	safe	safe	ADJ
admet-829	172	14	space	space	NOUN
admet-829	172	15	and	and	CCONJ
admet-829	172	16	for	for	ADP
admet-829	172	17	providing	provide	VERB
admet-829	172	18	confidence	confidence	NOUN
admet-829	172	19	in	in	ADP
admet-829	172	20	making	make	VERB
admet-829	172	21	predictions	prediction	NOUN
admet-829	172	22	.	.	PUNCT
admet-829	173	1	the	the	DET
admet-829	173	2	hope	hope	NOUN
admet-829	173	3	is	be	AUX
admet-829	173	4	that	that	SCONJ
admet-829	173	5	a	a	DET
admet-829	173	6	simple	simple	ADJ
admet-829	173	7	dissolution	dissolution	NOUN
admet-829	173	8	test	test	NOUN
admet-829	173	9	could	could	AUX
admet-829	173	10	serve	serve	VERB
admet-829	173	11	to	to	PART
admet-829	173	12	establish	establish	VERB
admet-829	173	13	bioequivalence	bioequivalence	NOUN
admet-829	173	14	in	in	ADP
admet-829	173	15	conjunction	conjunction	NOUN
admet-829	173	16	with	with	ADP
admet-829	173	17	pbpk	pbpk	NOUN
admet-829	173	18	modeling	modeling	NOUN
admet-829	173	19	.	.	PUNCT
admet-829	174	1	the	the	DET
admet-829	174	2	theoretical	theoretical	ADJ
admet-829	174	3	advantage	advantage	NOUN
admet-829	174	4	of	of	ADP
admet-829	174	5	the	the	DET
admet-829	174	6	mmp	mmp	PROPN
admet-829	174	7	model	model	NOUN
admet-829	174	8	lies	lie	VERB
admet-829	174	9	in	in	ADP
admet-829	174	10	its	its	PRON
admet-829	174	11	mechanistically	mechanistically	ADV
admet-829	174	12	-	-	PUNCT
admet-829	174	13	based	base	VERB
admet-829	174	14	mathematical	mathematical	ADJ
admet-829	174	15	integration	integration	NOUN
admet-829	174	16	of	of	ADP
admet-829	174	17	dissolution	dissolution	NOUN
admet-829	174	18	,	,	PUNCT
admet-829	174	19	gastric	gastric	ADJ
admet-829	174	20	emptying	emptying	NOUN
admet-829	174	21	,	,	PUNCT
admet-829	174	22	and	and	CCONJ
admet-829	174	23	intestinal	intestinal	ADJ
admet-829	174	24	motility	motility	NOUN
admet-829	174	25	in	in	ADP
admet-829	174	26	a	a	DET
admet-829	174	27	way	way	NOUN
admet-829	174	28	that	that	PRON
admet-829	174	29	is	be	AUX
admet-829	174	30	closer	close	ADJ
admet-829	174	31	to	to	ADP
admet-829	174	32	how	how	SCONJ
admet-829	174	33	these	these	DET
admet-829	174	34	processes	process	NOUN
admet-829	174	35	occur	occur	VERB
admet-829	174	36	in	in	ADP
admet-829	174	37	the	the	DET
admet-829	174	38	gi	gi	NOUN
admet-829	174	39	tract	tract	NOUN
admet-829	174	40	.	.	PUNCT
admet-829	175	1	conclusions	conclusion	NOUN
admet-829	175	2	in	in	ADP
admet-829	175	3	conclusion	conclusion	NOUN
admet-829	175	4	,	,	PUNCT
admet-829	175	5	the	the	DET
admet-829	175	6	mmp	mmp	PROPN
admet-829	175	7	model	model	NOUN
admet-829	175	8	provides	provide	VERB
admet-829	175	9	a	a	DET
admet-829	175	10	more	more	ADV
admet-829	175	11	mechanistically	mechanistically	ADV
admet-829	175	12	realistic	realistic	ADJ
admet-829	175	13	computational	computational	ADJ
admet-829	175	14	tool	tool	NOUN
admet-829	175	15	to	to	PART
admet-829	175	16	study	study	VERB
admet-829	175	17	the	the	DET
admet-829	175	18	effects	effect	NOUN
admet-829	175	19	of	of	ADP
admet-829	175	20	dissolution	dissolution	NOUN
admet-829	175	21	,	,	PUNCT
admet-829	175	22	gastric	gastric	ADJ
admet-829	175	23	emptying	emptying	NOUN
admet-829	175	24	,	,	PUNCT
admet-829	175	25	and	and	CCONJ
admet-829	175	26	intestinal	intestinal	ADJ
admet-829	175	27	motility	motility	NOUN
admet-829	175	28	on	on	ADP
admet-829	175	29	the	the	DET
admet-829	175	30	drug	drug	NOUN
admet-829	175	31	plasma	plasma	NOUN
admet-829	175	32	concentration	concentration	NOUN
admet-829	175	33	profile	profile	NOUN
admet-829	175	34	.	.	PUNCT
admet-829	176	1	the	the	DET
admet-829	176	2	ability	ability	NOUN
admet-829	176	3	to	to	PART
admet-829	176	4	establish	establish	VERB
admet-829	176	5	the	the	DET
admet-829	176	6	impact	impact	NOUN
admet-829	176	7	of	of	ADP
admet-829	176	8	dissolution	dissolution	NOUN
admet-829	176	9	and	and	CCONJ
admet-829	176	10	gi	gi	ADP
admet-829	176	11	motility	motility	NOUN
admet-829	176	12	on	on	ADP
admet-829	176	13	bioequivalence	bioequivalence	NOUN
admet-829	176	14	criteria	criterion	NOUN
admet-829	176	15	may	may	AUX
admet-829	176	16	expand	expand	VERB
admet-829	176	17	safe	safe	ADJ
admet-829	176	18	space	space	NOUN
admet-829	176	19	for	for	ADP
admet-829	176	20	regulatory	regulatory	ADJ
admet-829	176	21	approval	approval	NOUN
admet-829	176	22	of	of	ADP
admet-829	176	23	pharmaceutical	pharmaceutical	NOUN
admet-829	176	24	products	product	NOUN
admet-829	176	25	based	base	VERB
admet-829	176	26	on	on	ADP
admet-829	176	27	limited	limited	ADJ
admet-829	176	28	dissolution	dissolution	NOUN
admet-829	176	29	data	datum	NOUN
admet-829	176	30	and	and	CCONJ
admet-829	176	31	mechanistically	mechanistically	ADV
admet-829	176	32	-	-	PUNCT
admet-829	176	33	based	base	VERB
admet-829	176	34	simulations	simulation	NOUN
admet-829	176	35	.	.	PUNCT
admet-829	177	1	acknowledgements	acknowledgement	NOUN
admet-829	177	2	:	:	PUNCT
admet-829	177	3	the	the	DET
admet-829	177	4	author	author	NOUN
admet-829	177	5	would	would	AUX
admet-829	177	6	like	like	VERB
admet-829	177	7	to	to	PART
admet-829	177	8	thank	thank	VERB
admet-829	177	9	michael	michael	PROPN
admet-829	177	10	camilleri	camilleri	PROPN
admet-829	177	11	,	,	PUNCT
admet-829	177	12	md	md	PROPN
admet-829	177	13	of	of	ADP
admet-829	177	14	the	the	DET
admet-829	177	15	mayo	mayo	NOUN
admet-829	177	16	clinic	clinic	PROPN
admet-829	177	17	for	for	ADP
admet-829	177	18	his	his	PRON
admet-829	177	19	helpful	helpful	ADJ
admet-829	177	20	discussion	discussion	NOUN
admet-829	177	21	.	.	PUNCT
admet-829	178	1	conflict	conflict	NOUN
admet-829	178	2	of	of	ADP
admet-829	178	3	interest	interest	NOUN
admet-829	178	4	:	:	PUNCT
admet-829	178	5	the	the	DET
admet-829	178	6	author	author	NOUN
admet-829	178	7	is	be	AUX
admet-829	178	8	the	the	DET
admet-829	178	9	president	president	NOUN
admet-829	178	10	of	of	ADP
admet-829	178	11	intellipharm	intellipharm	PROPN
admet-829	178	12	llc	llc	PROPN
admet-829	178	13	.	.	PUNCT
admet-829	179	1	references	reference	NOUN
admet-829	179	2	[	[	X
admet-829	179	3	1	1	NUM
admet-829	179	4	]	]	PUNCT
admet-829	179	5	a.	a.	NOUN
admet-829	179	6	talattof	talattof	PROPN
admet-829	179	7	,	,	PUNCT
admet-829	179	8	g.l	g.l	PROPN
admet-829	179	9	.	.	PROPN
admet-829	179	10	amidon	amidon	PROPN
admet-829	179	11	.	.	PUNCT
admet-829	180	1	pulse	pulse	NOUN
admet-829	180	2	packet	packet	NOUN
admet-829	180	3	stochastic	stochastic	NOUN
admet-829	180	4	model	model	NOUN
admet-829	180	5	for	for	ADP
admet-829	180	6	gastric	gastric	ADJ
admet-829	180	7	emptying	empty	VERB
admet-829	180	8	in	in	ADP
admet-829	180	9	the	the	DET
admet-829	180	10	fasted	fasted	ADJ
admet-829	180	11	state	state	NOUN
admet-829	180	12	:	:	PUNCT
admet-829	180	13	a	a	DET
admet-829	180	14	physiological	physiological	ADJ
admet-829	180	15	approach	approach	NOUN
admet-829	180	16	.	.	PUNCT
admet-829	181	1	mol	mol	PROPN
admet-829	181	2	.	.	PUNCT
admet-829	181	3	pharm	pharm	PROPN
admet-829	181	4	.	.	PUNCT
admet-829	182	1	15	15	NUM
admet-829	182	2	(	(	PUNCT
admet-829	182	3	2018	2018	NUM
admet-829	182	4	)	)	PUNCT
admet-829	182	5	2107	2107	NUM
admet-829	182	6	-	-	SYM
admet-829	182	7	2115	2115	NUM
admet-829	182	8	.	.	PUNCT
admet-829	183	1	admet	admet	PROPN
admet-829	183	2	&	&	CCONJ
admet-829	183	3	dmpk	dmpk	PROPN
admet-829	183	4	8(3	8(3	NUM
admet-829	183	5	)	)	PUNCT
admet-829	183	6	(	(	PUNCT
admet-829	183	7	2020	2020	NUM
admet-829	183	8	)	)	PUNCT
admet-829	183	9	314	314	NUM
admet-829	183	10	-	-	SYM
admet-829	183	11	324	324	NUM
admet-829	183	12	mechanistic	mechanistic	ADJ
admet-829	183	13	modeling	modeling	NOUN
admet-829	183	14	of	of	ADP
admet-829	183	15	gastrointestinal	gastrointestinal	ADJ
admet-829	183	16	motility	motility	NOUN
admet-829	183	17	doi	doi	NOUN
admet-829	183	18	:	:	PUNCT
admet-829	183	19	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	NOUN
admet-829	183	20	323	323	NUM
admet-829	183	21	[	[	X
admet-829	183	22	2	2	X
admet-829	183	23	]	]	PUNCT
admet-829	183	24	j.	j.	PROPN
admet-829	183	25	yokrattanasak	yokrattanasak	PROPN
admet-829	183	26	,	,	PUNCT
admet-829	183	27	a.	a.	PROPN
admet-829	183	28	de	de	PROPN
admet-829	183	29	gaetano	gaetano	PROPN
admet-829	183	30	,	,	PUNCT
admet-829	183	31	s.	s.	PROPN
admet-829	183	32	panunzi	panunzi	PROPN
admet-829	183	33	,	,	PUNCT
admet-829	183	34	p.	p.	PROPN
admet-829	183	35	satiracoo	satiracoo	PROPN
admet-829	183	36	,	,	PUNCT
admet-829	183	37	w.m	w.m	PROPN
admet-829	183	38	.	.	PROPN
admet-829	183	39	lawton	lawton	PROPN
admet-829	183	40	,	,	PUNCT
admet-829	183	41	y.	y.	PROPN
admet-829	183	42	lenbury	lenbury	PROPN
admet-829	183	43	.	.	PUNCT
admet-829	184	1	a	a	DET
admet-829	184	2	simple	simple	ADJ
admet-829	184	3	,	,	PUNCT
admet-829	184	4	realistic	realistic	ADJ
admet-829	184	5	stochastic	stochastic	ADJ
admet-829	184	6	model	model	NOUN
admet-829	184	7	of	of	ADP
admet-829	184	8	gastric	gastric	ADJ
admet-829	184	9	emptying	emptying	NOUN
admet-829	184	10	.	.	PUNCT
admet-829	185	1	plos	plos	PROPN
admet-829	185	2	one	one	NUM
admet-829	185	3	11	11	NUM
admet-829	185	4	(	(	PUNCT
admet-829	185	5	2016	2016	NUM
admet-829	185	6	)	)	PUNCT
admet-829	185	7	e0153297	e0153297	NOUN
admet-829	185	8	.	.	PUNCT
admet-829	186	1	[	[	X
admet-829	186	2	3	3	X
admet-829	186	3	]	]	X
admet-829	186	4	k.c	k.c	PROPN
admet-829	186	5	.	.	PROPN
admet-829	186	6	johnson	johnson	PROPN
admet-829	186	7	,	,	PUNCT
admet-829	186	8	computer	computer	NOUN
admet-829	186	9	simulation	simulation	NOUN
admet-829	186	10	for	for	ADP
admet-829	186	11	pharmaceutical	pharmaceutical	ADJ
admet-829	186	12	scientists	scientist	NOUN
admet-829	186	13	,	,	PUNCT
admet-829	186	14	intellipharm	intellipharm	NOUN
admet-829	186	15	press	press	NOUN
admet-829	186	16	,	,	PUNCT
admet-829	186	17	niantic	niantic	PROPN
admet-829	186	18	,	,	PUNCT
admet-829	186	19	connecticut	connecticut	PROPN
admet-829	186	20	,	,	PUNCT
admet-829	186	21	usa	usa	PROPN
admet-829	186	22	,	,	PUNCT
admet-829	186	23	2018	2018	NUM
admet-829	186	24	,	,	PUNCT
admet-829	186	25	p	p	X
admet-829	186	26	53	53	NUM
admet-829	186	27	.	.	PUNCT
admet-829	187	1	[	[	X
admet-829	187	2	4	4	X
admet-829	187	3	]	]	X
admet-829	187	4	d.m	d.m	PROPN
admet-829	187	5	.	.	PROPN
admet-829	187	6	mudie	mudie	PROPN
admet-829	187	7	,	,	PUNCT
admet-829	187	8	k.	k.	PROPN
admet-829	187	9	murray	murray	PROPN
admet-829	187	10	,	,	PUNCT
admet-829	187	11	c.l	c.l	PROPN
admet-829	187	12	.	.	PROPN
admet-829	187	13	hoad	hoad	PROPN
admet-829	187	14	,	,	PUNCT
admet-829	187	15	s.e	s.e	PROPN
admet-829	187	16	.	.	PROPN
admet-829	187	17	pritchard	pritchard	PROPN
admet-829	187	18	,	,	PUNCT
admet-829	187	19	m.c	m.c	PROPN
admet-829	187	20	.	.	PROPN
admet-829	187	21	garnett	garnett	PROPN
admet-829	187	22	,	,	PUNCT
admet-829	187	23	g.l	g.l	PROPN
admet-829	187	24	.	.	PROPN
admet-829	187	25	amidon	amidon	PROPN
admet-829	187	26	,	,	PUNCT
admet-829	187	27	p.a	p.a	PROPN
admet-829	187	28	.	.	PROPN
admet-829	187	29	gowland	gowland	PROPN
admet-829	187	30	,	,	PUNCT
admet-829	187	31	r.c	r.c	PROPN
admet-829	187	32	.	.	PROPN
admet-829	187	33	spiller	spiller	PROPN
admet-829	187	34	,	,	PUNCT
admet-829	187	35	g.e	g.e	PROPN
admet-829	187	36	.	.	PROPN
admet-829	187	37	amidon	amidon	PROPN
admet-829	187	38	,	,	PUNCT
admet-829	187	39	l.	l.	PROPN
admet-829	187	40	marciani	marciani	PROPN
admet-829	187	41	.	.	PUNCT
admet-829	188	1	quantification	quantification	NOUN
admet-829	188	2	of	of	ADP
admet-829	188	3	gastrointestinal	gastrointestinal	ADJ
admet-829	188	4	liquid	liquid	ADJ
admet-829	188	5	volumes	volume	NOUN
admet-829	188	6	and	and	CCONJ
admet-829	188	7	distribution	distribution	NOUN
admet-829	188	8	following	follow	VERB
admet-829	188	9	a	a	DET
admet-829	188	10	240	240	NUM
admet-829	188	11	ml	ml	NOUN
admet-829	188	12	dose	dose	NOUN
admet-829	188	13	of	of	ADP
admet-829	188	14	water	water	NOUN
admet-829	188	15	in	in	ADP
admet-829	188	16	the	the	DET
admet-829	188	17	fasted	fasted	ADJ
admet-829	188	18	state	state	NOUN
admet-829	188	19	.	.	PUNCT
admet-829	189	1	mol	mol	PROPN
admet-829	189	2	.	.	PUNCT
admet-829	189	3	pharm	pharm	PROPN
admet-829	189	4	.	.	PUNCT
admet-829	190	1	11	11	NUM
admet-829	190	2	(	(	PUNCT
admet-829	190	3	2014	2014	NUM
admet-829	190	4	)	)	PUNCT
admet-829	190	5	3039	3039	NUM
admet-829	190	6	-	-	SYM
admet-829	190	7	3047	3047	NUM
admet-829	190	8	.	.	PUNCT
admet-829	191	1	[	[	X
admet-829	191	2	5	5	X
admet-829	191	3	]	]	PUNCT
admet-829	191	4	k.	k.	PROPN
admet-829	191	5	murray	murray	PROPN
admet-829	191	6	,	,	PUNCT
admet-829	191	7	c.l	c.l	PROPN
admet-829	191	8	.	.	PROPN
admet-829	191	9	hoad	hoad	PROPN
admet-829	191	10	,	,	PUNCT
admet-829	191	11	d.m	d.m	PROPN
admet-829	191	12	.	.	PROPN
admet-829	191	13	mudie	mudie	PROPN
admet-829	191	14	,	,	PUNCT
admet-829	191	15	j.	j.	PROPN
admet-829	191	16	wright	wright	PROPN
admet-829	191	17	,	,	PUNCT
admet-829	191	18	k.	k.	PROPN
admet-829	191	19	heissam	heissam	PROPN
admet-829	191	20	,	,	PUNCT
admet-829	191	21	n.	n.	PROPN
admet-829	191	22	abrehart	abrehart	PROPN
admet-829	191	23	,	,	PUNCT
admet-829	191	24	s.e	s.e	PROPN
admet-829	191	25	.	.	PROPN
admet-829	191	26	pritchard	pritchard	PROPN
admet-829	191	27	,	,	PUNCT
admet-829	191	28	s.	s.	PROPN
admet-829	191	29	al	al	PROPN
admet-829	191	30	atwah	atwah	PROPN
admet-829	191	31	,	,	PUNCT
admet-829	191	32	p.a	p.a	PROPN
admet-829	191	33	.	.	PROPN
admet-829	191	34	gowland	gowland	PROPN
admet-829	191	35	,	,	PUNCT
admet-829	191	36	m.c	m.c	PROPN
admet-829	191	37	.	.	PROPN
admet-829	191	38	garnett	garnett	PROPN
admet-829	191	39	,	,	PUNCT
admet-829	191	40	g.e	g.e	PROPN
admet-829	191	41	.	.	PROPN
admet-829	191	42	amidon	amidon	PROPN
admet-829	191	43	,	,	PUNCT
admet-829	191	44	r.c	r.c	PROPN
admet-829	191	45	.	.	PROPN
admet-829	191	46	spiller	spiller	PROPN
admet-829	191	47	,	,	PUNCT
admet-829	191	48	g.l	g.l	PROPN
admet-829	191	49	.	.	PROPN
admet-829	191	50	amidon	amidon	PROPN
admet-829	191	51	,	,	PUNCT
admet-829	191	52	l.	l.	PROPN
admet-829	191	53	marciani	marciani	PROPN
admet-829	191	54	.	.	PUNCT
admet-829	192	1	magnetic	magnetic	ADJ
admet-829	192	2	resonance	resonance	NOUN
admet-829	192	3	imaging	image	VERB
admet-829	192	4	quantification	quantification	NOUN
admet-829	192	5	of	of	ADP
admet-829	192	6	fasted	fast	VERB
admet-829	192	7	state	state	NOUN
admet-829	192	8	colonic	colonic	ADJ
admet-829	192	9	liquid	liquid	ADJ
admet-829	192	10	pockets	pocket	NOUN
admet-829	192	11	in	in	ADP
admet-829	192	12	healthy	healthy	ADJ
admet-829	192	13	humans	human	NOUN
admet-829	192	14	.	.	PUNCT
admet-829	193	1	mol	mol	PROPN
admet-829	193	2	.	.	PUNCT
admet-829	193	3	pharm	pharm	PROPN
admet-829	193	4	.	.	PUNCT
admet-829	194	1	14	14	NUM
admet-829	194	2	(	(	PUNCT
admet-829	194	3	2017	2017	NUM
admet-829	194	4	)	)	PUNCT
admet-829	194	5	2629	2629	NUM
admet-829	194	6	-	-	SYM
admet-829	194	7	2638	2638	NUM
admet-829	194	8	.	.	PUNCT
admet-829	195	1	[	[	X
admet-829	195	2	6	6	NUM
admet-829	195	3	]	]	PUNCT
admet-829	195	4	c.	c.	PROPN
admet-829	195	5	schiller	schiller	PROPN
admet-829	195	6	,	,	PUNCT
admet-829	195	7	c.p	c.p	PROPN
admet-829	195	8	.	.	PROPN
admet-829	195	9	fröhlich	fröhlich	PROPN
admet-829	195	10	,	,	PUNCT
admet-829	195	11	t.	t.	PROPN
admet-829	195	12	giessmann	giessmann	PROPN
admet-829	195	13	,	,	PUNCT
admet-829	195	14	w.	w.	PROPN
admet-829	195	15	siegmund	siegmund	PROPN
admet-829	195	16	,	,	PUNCT
admet-829	195	17	h.	h.	PROPN
admet-829	195	18	mönnikes	mönnikes	PROPN
admet-829	195	19	,	,	PUNCT
admet-829	195	20	n.	n.	NOUN
admet-829	195	21	hosten	hosten	PROPN
admet-829	195	22	,	,	PUNCT
admet-829	195	23	w.	w.	PROPN
admet-829	195	24	weitschies	weitschie	NOUN
admet-829	195	25	.	.	PUNCT
admet-829	196	1	intestinal	intestinal	ADJ
admet-829	196	2	fluid	fluid	ADJ
admet-829	196	3	volumes	volume	NOUN
admet-829	196	4	and	and	CCONJ
admet-829	196	5	transit	transit	NOUN
admet-829	196	6	of	of	ADP
admet-829	196	7	dosage	dosage	NOUN
admet-829	196	8	forms	form	NOUN
admet-829	196	9	as	as	SCONJ
admet-829	196	10	assessed	assess	VERB
admet-829	196	11	by	by	ADP
admet-829	196	12	magnetic	magnetic	ADJ
admet-829	196	13	resonance	resonance	NOUN
admet-829	196	14	imaging	imaging	NOUN
admet-829	196	15	.	.	PUNCT
admet-829	197	1	aliment	aliment	NOUN
admet-829	197	2	.	.	PUNCT
admet-829	198	1	pharmacol	pharmacol	PROPN
admet-829	198	2	.	.	PUNCT
admet-829	199	1	ther	ther	PROPN
admet-829	199	2	.	.	PUNCT
admet-829	200	1	22	22	NUM
admet-829	200	2	(	(	PUNCT
admet-829	200	3	2005	2005	NUM
admet-829	200	4	)	)	PUNCT
admet-829	200	5	971	971	NUM
admet-829	200	6	-	-	SYM
admet-829	200	7	979	979	NUM
admet-829	200	8	.	.	PUNCT
admet-829	201	1	[	[	X
admet-829	201	2	7	7	NUM
admet-829	201	3	]	]	X
admet-829	201	4	r.j	r.j	PROPN
admet-829	201	5	.	.	PROPN
admet-829	201	6	hintz	hintz	PROPN
admet-829	201	7	,	,	PUNCT
admet-829	201	8	k.c	k.c	PROPN
admet-829	201	9	.	.	PROPN
admet-829	201	10	johnson	johnson	PROPN
admet-829	201	11	.	.	PUNCT
admet-829	202	1	the	the	DET
admet-829	202	2	effect	effect	NOUN
admet-829	202	3	of	of	ADP
admet-829	202	4	particle	particle	NOUN
admet-829	202	5	size	size	NOUN
admet-829	202	6	distribution	distribution	NOUN
admet-829	202	7	on	on	ADP
admet-829	202	8	dissolution	dissolution	ADJ
admet-829	202	9	rate	rate	NOUN
admet-829	202	10	and	and	CCONJ
admet-829	202	11	oral	oral	ADJ
admet-829	202	12	absorption	absorption	NOUN
admet-829	202	13	.	.	PUNCT
admet-829	203	1	int	int	NOUN
admet-829	203	2	.	.	PUNCT
admet-829	204	1	j.	j.	PROPN
admet-829	204	2	pharm	pharm	PROPN
admet-829	204	3	.	.	PUNCT
admet-829	205	1	51	51	NUM
admet-829	205	2	(	(	PUNCT
admet-829	205	3	1989	1989	NUM
admet-829	205	4	)	)	PUNCT
admet-829	205	5	9	9	NUM
admet-829	205	6	-	-	SYM
admet-829	205	7	17	17	NUM
admet-829	205	8	.	.	PUNCT
admet-829	206	1	[	[	X
admet-829	206	2	8	8	NUM
admet-829	206	3	]	]	X
admet-829	206	4	a.t	a.t	PROPN
admet-829	206	5	.	.	PROPN
admet-829	206	6	lu	lu	PROPN
admet-829	206	7	,	,	PUNCT
admet-829	206	8	m.e	m.e	PROPN
admet-829	206	9	.	.	PROPN
admet-829	206	10	frisella	frisella	PROPN
admet-829	206	11	,	,	PUNCT
admet-829	206	12	k.c	k.c	PROPN
admet-829	206	13	.	.	PROPN
admet-829	206	14	johnson	johnson	PROPN
admet-829	206	15	.	.	PUNCT
admet-829	207	1	dissolution	dissolution	PROPN
admet-829	207	2	modeling	modeling	NOUN
admet-829	207	3	:	:	PUNCT
admet-829	207	4	factors	factor	NOUN
admet-829	207	5	affecting	affect	VERB
admet-829	207	6	the	the	DET
admet-829	207	7	dissolution	dissolution	NOUN
admet-829	207	8	rates	rate	NOUN
admet-829	207	9	of	of	ADP
admet-829	207	10	polydisperse	polydisperse	NOUN
admet-829	207	11	powders	powder	NOUN
admet-829	207	12	.	.	PUNCT
admet-829	208	1	pharm	pharm	NOUN
admet-829	208	2	.	.	PUNCT
admet-829	209	1	res	re	NOUN
admet-829	209	2	.	.	PROPN
admet-829	210	1	10	10	NUM
admet-829	210	2	(	(	PUNCT
admet-829	210	3	1993	1993	NUM
admet-829	210	4	)	)	PUNCT
admet-829	210	5	1308	1308	NUM
admet-829	210	6	-	-	SYM
admet-829	210	7	1314	1314	NUM
admet-829	210	8	.	.	PUNCT
admet-829	211	1	[	[	X
admet-829	211	2	9	9	X
admet-829	211	3	]	]	PUNCT
admet-829	211	4	j.	j.	PROPN
admet-829	211	5	jinno	jinno	PROPN
admet-829	211	6	,	,	PUNCT
admet-829	211	7	n.	n.	PROPN
admet-829	211	8	kamada	kamada	PROPN
admet-829	211	9	,	,	PUNCT
admet-829	211	10	m.	m.	PROPN
admet-829	211	11	miyake	miyake	PROPN
admet-829	211	12	,	,	PUNCT
admet-829	211	13	k.	k.	PROPN
admet-829	211	14	yamada	yamada	PROPN
admet-829	211	15	,	,	PUNCT
admet-829	211	16	t.	t.	PROPN
admet-829	211	17	mukai	mukai	PROPN
admet-829	211	18	,	,	PUNCT
admet-829	211	19	m.	m.	NOUN
admet-829	211	20	odomi	odomi	PROPN
admet-829	211	21	,	,	PUNCT
admet-829	211	22	h.	h.	PROPN
admet-829	211	23	toguchi	toguchi	PROPN
admet-829	211	24	,	,	PUNCT
admet-829	211	25	g.g	g.g	PROPN
admet-829	211	26	.	.	PROPN
admet-829	211	27	liversidge	liversidge	PROPN
admet-829	211	28	,	,	PUNCT
admet-829	211	29	k.	k.	PROPN
admet-829	211	30	higaki	higaki	PROPN
admet-829	211	31	,	,	PUNCT
admet-829	211	32	t.	t.	PROPN
admet-829	211	33	kimura	kimura	NOUN
admet-829	211	34	.	.	PUNCT
admet-829	212	1	effect	effect	NOUN
admet-829	212	2	of	of	ADP
admet-829	212	3	particle	particle	NOUN
admet-829	212	4	size	size	NOUN
admet-829	212	5	reduction	reduction	NOUN
admet-829	212	6	on	on	ADP
admet-829	212	7	dissolution	dissolution	NOUN
admet-829	212	8	and	and	CCONJ
admet-829	212	9	oral	oral	ADJ
admet-829	212	10	absorption	absorption	NOUN
admet-829	212	11	of	of	ADP
admet-829	212	12	a	a	DET
admet-829	212	13	poorly	poorly	ADV
admet-829	212	14	water	water	NOUN
admet-829	212	15	-	-	PUNCT
admet-829	212	16	soluble	soluble	ADJ
admet-829	212	17	drug	drug	NOUN
admet-829	212	18	,	,	PUNCT
admet-829	212	19	cilostazol	cilostazol	ADJ
admet-829	212	20	,	,	PUNCT
admet-829	212	21	in	in	ADP
admet-829	212	22	beagle	beagle	NOUN
admet-829	212	23	dogs	dog	NOUN
admet-829	212	24	.	.	PUNCT
admet-829	213	1	j.	j.	PROPN
admet-829	213	2	control	control	PROPN
admet-829	213	3	.	.	PUNCT
admet-829	214	1	release	release	VERB
admet-829	214	2	111	111	NUM
admet-829	214	3	(	(	PUNCT
admet-829	214	4	2006	2006	NUM
admet-829	214	5	)	)	PUNCT
admet-829	214	6	56	56	NUM
admet-829	214	7	-	-	SYM
admet-829	214	8	64	64	NUM
admet-829	214	9	.	.	PUNCT
admet-829	215	1	[	[	X
admet-829	215	2	10	10	NUM
admet-829	215	3	]	]	X
admet-829	215	4	t.s	t.s	PROPN
admet-829	215	5	.	.	PROPN
admet-829	215	6	samant	samant	PROPN
admet-829	215	7	,	,	PUNCT
admet-829	215	8	s.	s.	PROPN
admet-829	215	9	dhuria	dhuria	PROPN
admet-829	215	10	,	,	PUNCT
admet-829	215	11	y.	y.	PROPN
admet-829	215	12	lu	lu	PROPN
admet-829	215	13	,	,	PUNCT
admet-829	215	14	m.	m.	NOUN
admet-829	215	15	laisney	laisney	PROPN
admet-829	215	16	,	,	PUNCT
admet-829	215	17	s.	s.	PROPN
admet-829	215	18	yang	yang	PROPN
admet-829	215	19	,	,	PUNCT
admet-829	215	20	a.	a.	PROPN
admet-829	215	21	grandeury	grandeury	PROPN
admet-829	215	22	,	,	PUNCT
admet-829	215	23	m.	m.	NOUN
admet-829	215	24	mueller	mueller	PROPN
admet-829	215	25	-	-	PUNCT
admet-829	215	26	zsigmondy	zsigmondy	PROPN
admet-829	215	27	,	,	PUNCT
admet-829	215	28	k.	k.	PROPN
admet-829	215	29	umehara	umehara	PROPN
admet-829	215	30	,	,	PUNCT
admet-829	215	31	f.	f.	PROPN
admet-829	215	32	huth	huth	PROPN
admet-829	215	33	,	,	PUNCT
admet-829	215	34	m.	m.	NOUN
admet-829	215	35	miller	miller	PROPN
admet-829	215	36	,	,	PUNCT
admet-829	215	37	c.	c.	PROPN
admet-829	215	38	germa	germa	NOUN
admet-829	215	39	,	,	PUNCT
admet-829	215	40	m.	m.	NOUN
admet-829	215	41	elmeliegy	elmeliegy	PROPN
admet-829	215	42	.	.	PUNCT
admet-829	216	1	ribociclib	ribociclib	NOUN
admet-829	216	2	bioavailability	bioavailability	NOUN
admet-829	216	3	is	be	AUX
admet-829	216	4	not	not	PART
admet-829	216	5	affected	affect	VERB
admet-829	216	6	by	by	ADP
admet-829	216	7	gastric	gastric	ADJ
admet-829	216	8	ph	ph	ADJ
admet-829	216	9	changes	change	NOUN
admet-829	216	10	or	or	CCONJ
admet-829	216	11	food	food	NOUN
admet-829	216	12	intake	intake	NOUN
admet-829	216	13	:	:	PUNCT
admet-829	216	14	in	in	ADP
admet-829	216	15	silico	silico	NOUN
admet-829	216	16	and	and	CCONJ
admet-829	216	17	clinical	clinical	ADJ
admet-829	216	18	evaluations	evaluation	NOUN
admet-829	216	19	.	.	PUNCT
admet-829	217	1	clin	clin	PROPN
admet-829	217	2	.	.	PUNCT
admet-829	218	1	pharmacol	pharmacol	PROPN
admet-829	218	2	.	.	PUNCT
admet-829	219	1	ther	ther	PROPN
admet-829	219	2	.	.	PUNCT
admet-829	220	1	104	104	NUM
admet-829	220	2	(	(	PUNCT
admet-829	220	3	2018	2018	NUM
admet-829	220	4	)	)	PUNCT
admet-829	220	5	374	374	NUM
admet-829	220	6	-	-	SYM
admet-829	220	7	383	383	NUM
admet-829	220	8	.	.	PUNCT
admet-829	221	1	[	[	X
admet-829	221	2	11	11	NUM
admet-829	221	3	]	]	X
admet-829	221	4	d.m	d.m	PROPN
admet-829	221	5	.	.	PROPN
admet-829	221	6	mudie	mudie	PROPN
admet-829	221	7	,	,	PUNCT
admet-829	221	8	g.l	g.l	PROPN
admet-829	221	9	.	.	PROPN
admet-829	221	10	amidon	amidon	PROPN
admet-829	221	11	,	,	PUNCT
admet-829	221	12	g.e	g.e	PROPN
admet-829	221	13	.	.	PROPN
admet-829	221	14	amidon	amidon	PROPN
admet-829	221	15	.	.	PUNCT
admet-829	222	1	physiological	physiological	ADJ
admet-829	222	2	parameters	parameter	NOUN
admet-829	222	3	for	for	ADP
admet-829	222	4	oral	oral	ADJ
admet-829	222	5	delivery	delivery	NOUN
admet-829	222	6	and	and	CCONJ
admet-829	222	7	in	in	ADP
admet-829	222	8	vitro	vitro	X
admet-829	222	9	testing	testing	NOUN
admet-829	222	10	.	.	PUNCT
admet-829	223	1	mol	mol	PROPN
admet-829	223	2	.	.	PUNCT
admet-829	223	3	pharm	pharm	PROPN
admet-829	223	4	.	.	PUNCT
admet-829	224	1	7	7	NUM
admet-829	224	2	(	(	PUNCT
admet-829	224	3	2010	2010	NUM
admet-829	224	4	)	)	PUNCT
admet-829	224	5	1388	1388	NUM
admet-829	224	6	-	-	SYM
admet-829	224	7	1405	1405	NUM
admet-829	224	8	.	.	PUNCT
admet-829	225	1	[	[	X
admet-829	225	2	12	12	NUM
admet-829	225	3	]	]	X
admet-829	225	4	k.c	k.c	PROPN
admet-829	225	5	.	.	PROPN
admet-829	225	6	johnson	johnson	PROPN
admet-829	225	7	.	.	PUNCT
admet-829	226	1	dissolution	dissolution	PROPN
admet-829	226	2	and	and	CCONJ
admet-829	226	3	absorption	absorption	NOUN
admet-829	226	4	modeling	modeling	NOUN
admet-829	226	5	:	:	PUNCT
admet-829	226	6	model	model	NOUN
admet-829	226	7	expansion	expansion	NOUN
admet-829	226	8	to	to	PART
admet-829	226	9	simulate	simulate	VERB
admet-829	226	10	the	the	DET
admet-829	226	11	effects	effect	NOUN
admet-829	226	12	of	of	ADP
admet-829	226	13	precipitation	precipitation	NOUN
admet-829	226	14	,	,	PUNCT
admet-829	226	15	water	water	NOUN
admet-829	226	16	absorption	absorption	NOUN
admet-829	226	17	,	,	PUNCT
admet-829	226	18	longitudinally	longitudinally	ADV
admet-829	226	19	changing	change	VERB
admet-829	226	20	intestinal	intestinal	ADJ
admet-829	226	21	permeability	permeability	NOUN
admet-829	226	22	,	,	PUNCT
admet-829	226	23	and	and	CCONJ
admet-829	226	24	controlled	control	VERB
admet-829	226	25	release	release	NOUN
admet-829	226	26	on	on	ADP
admet-829	226	27	drug	drug	NOUN
admet-829	226	28	absorption	absorption	NOUN
admet-829	226	29	.	.	PUNCT
admet-829	227	1	drug	drug	PROPN
admet-829	227	2	dev	dev	PROPN
admet-829	227	3	.	.	PUNCT
admet-829	228	1	ind	ind	PROPN
admet-829	228	2	.	.	PUNCT
admet-829	229	1	pharm	pharm	PROPN
admet-829	229	2	.	.	PUNCT
admet-829	230	1	29	29	NUM
admet-829	230	2	(	(	PUNCT
admet-829	230	3	2003	2003	NUM
admet-829	230	4	)	)	PUNCT
admet-829	230	5	833	833	NUM
admet-829	230	6	-	-	SYM
admet-829	230	7	842	842	NUM
admet-829	230	8	.	.	PUNCT
admet-829	231	1	[	[	X
admet-829	231	2	13	13	NUM
admet-829	231	3	]	]	PUNCT
admet-829	231	4	j.	j.	PROPN
admet-829	231	5	hirtz	hirtz	PROPN
admet-829	231	6	.	.	PUNCT
admet-829	232	1	the	the	DET
admet-829	232	2	gastrointestinal	gastrointestinal	ADJ
admet-829	232	3	absorption	absorption	NOUN
admet-829	232	4	of	of	ADP
admet-829	232	5	drugs	drug	NOUN
admet-829	232	6	in	in	ADP
admet-829	232	7	man	man	NOUN
admet-829	232	8	:	:	PUNCT
admet-829	232	9	a	a	DET
admet-829	232	10	review	review	NOUN
admet-829	232	11	of	of	ADP
admet-829	232	12	current	current	ADJ
admet-829	232	13	concepts	concept	NOUN
admet-829	232	14	and	and	CCONJ
admet-829	232	15	methods	method	NOUN
admet-829	232	16	of	of	ADP
admet-829	232	17	investigation	investigation	NOUN
admet-829	232	18	.	.	PUNCT
admet-829	233	1	br	br	PROPN
admet-829	233	2	.	.	PUNCT
admet-829	234	1	j.	j.	PROPN
admet-829	234	2	clin	clin	PROPN
admet-829	234	3	.	.	PUNCT
admet-829	235	1	pharmacol	pharmacol	PROPN
admet-829	235	2	.	.	PROPN
admet-829	236	1	19	19	NUM
admet-829	236	2	suppl.2	suppl.2	PROPN
admet-829	236	3	(	(	PUNCT
admet-829	236	4	1985	1985	NUM
admet-829	236	5	)	)	PUNCT
admet-829	236	6	77s-83s	77s-83s	NOUN
admet-829	236	7	.	.	PUNCT
admet-829	237	1	[	[	X
admet-829	237	2	14	14	NUM
admet-829	237	3	]	]	X
admet-829	237	4	b.	b.	PROPN
admet-829	237	5	hens	hens	PROPN
admet-829	237	6	,	,	PUNCT
admet-829	237	7	m.b	m.b	PROPN
admet-829	237	8	.	.	PROPN
admet-829	237	9	bolger	bolger	PROPN
admet-829	237	10	.	.	PUNCT
admet-829	237	11	application	application	NOUN
admet-829	237	12	of	of	ADP
admet-829	237	13	a	a	DET
admet-829	237	14	dynamic	dynamic	ADJ
admet-829	237	15	fluid	fluid	NOUN
admet-829	237	16	and	and	CCONJ
admet-829	237	17	ph	ph	ADJ
admet-829	237	18	model	model	NOUN
admet-829	237	19	to	to	PART
admet-829	237	20	simulate	simulate	VERB
admet-829	237	21	intraluminal	intraluminal	ADJ
admet-829	237	22	and	and	CCONJ
admet-829	237	23	systemic	systemic	ADJ
admet-829	237	24	concentrations	concentration	NOUN
admet-829	237	25	of	of	ADP
admet-829	237	26	a	a	DET
admet-829	237	27	weak	weak	ADJ
admet-829	237	28	base	base	NOUN
admet-829	237	29	in	in	ADP
admet-829	237	30	gastroplus	gastroplus	ADJ
admet-829	237	31	™	™	PROPN
admet-829	237	32	.	.	PUNCT
admet-829	238	1	j.	j.	PROPN
admet-829	238	2	pharm	pharm	PROPN
admet-829	238	3	.	.	PUNCT
admet-829	239	1	sci	sci	PROPN
admet-829	239	2	.	.	PROPN
admet-829	240	1	108	108	NUM
admet-829	240	2	(	(	PUNCT
admet-829	240	3	2019	2019	NUM
admet-829	240	4	)	)	PUNCT
admet-829	240	5	305	305	NUM
admet-829	240	6	-	-	SYM
admet-829	240	7	315	315	NUM
admet-829	240	8	.	.	PUNCT
admet-829	241	1	[	[	X
admet-829	241	2	15	15	NUM
admet-829	241	3	]	]	X
admet-829	241	4	p.j	p.j	PROPN
admet-829	241	5	.	.	PROPN
admet-829	241	6	o'dwyer	o'dwyer	PROPN
admet-829	241	7	,	,	PUNCT
admet-829	241	8	c.	c.	PROPN
admet-829	241	9	litou	litou	PROPN
admet-829	241	10	,	,	PUNCT
admet-829	241	11	k.j	k.j	PROPN
admet-829	241	12	.	.	PROPN
admet-829	241	13	box	box	PROPN
admet-829	241	14	,	,	PUNCT
admet-829	241	15	j.b	j.b	PROPN
admet-829	241	16	.	.	PROPN
admet-829	241	17	dressman	dressman	PROPN
admet-829	241	18	,	,	PUNCT
admet-829	241	19	e.s	e.s	PROPN
admet-829	241	20	.	.	PROPN
admet-829	241	21	kostewicz	kostewicz	PROPN
admet-829	241	22	,	,	PUNCT
admet-829	241	23	m.	m.	NOUN
admet-829	241	24	kuentz	kuentz	PROPN
admet-829	241	25	,	,	PUNCT
admet-829	241	26	c.	c.	PROPN
admet-829	241	27	reppas	reppas	NOUN
admet-829	241	28	.	.	PUNCT
admet-829	242	1	in	in	ADP
admet-829	242	2	vitro	vitro	X
admet-829	242	3	methods	method	NOUN
admet-829	242	4	to	to	PART
admet-829	242	5	assess	assess	VERB
admet-829	242	6	drug	drug	NOUN
admet-829	242	7	precipitation	precipitation	NOUN
admet-829	242	8	in	in	ADP
admet-829	242	9	the	the	DET
admet-829	242	10	fasted	fast	VERB
admet-829	242	11	small	small	ADJ
admet-829	242	12	intestine	intestine	NOUN
admet-829	242	13	a	a	DET
admet-829	242	14	pearrl	pearrl	NOUN
admet-829	242	15	review	review	NOUN
admet-829	242	16	.	.	PUNCT
admet-829	243	1	j.	j.	PROPN
admet-829	243	2	pharm	pharm	PROPN
admet-829	243	3	.	.	PUNCT
admet-829	244	1	pharmacol	pharmacol	PROPN
admet-829	244	2	.	.	PUNCT
admet-829	245	1	71	71	NUM
admet-829	245	2	(	(	PUNCT
admet-829	245	3	2019	2019	NUM
admet-829	245	4	)	)	PUNCT
admet-829	245	5	536	536	NUM
admet-829	245	6	-	-	SYM
admet-829	245	7	556	556	NUM
admet-829	245	8	.	.	PUNCT
admet-829	246	1	[	[	X
admet-829	246	2	16	16	NUM
admet-829	246	3	]	]	X
admet-829	246	4	the	the	DET
admet-829	246	5	moving	move	VERB
admet-829	246	6	gut	gut	NOUN
admet-829	246	7	by	by	ADP
admet-829	246	8	hans	hans	PROPN
admet-829	246	9	jörg	jörg	PROPN
admet-829	246	10	ehrlein	ehrlein	PROPN
admet-829	246	11	and	and	CCONJ
admet-829	246	12	michael	michael	PROPN
admet-829	246	13	schemann	schemann	PROPN
admet-829	246	14	,	,	PUNCT
admet-829	246	15	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	PROPN
admet-829	246	16	(	(	PUNCT
admet-829	246	17	accessed	access	VERB
admet-829	246	18	march	march	PROPN
admet-829	246	19	11	11	NUM
admet-829	246	20	,	,	PUNCT
admet-829	246	21	2020	2020	NUM
admet-829	246	22	)	)	PUNCT
admet-829	246	23	.	.	PUNCT
admet-829	247	1	[	[	X
admet-829	247	2	17	17	NUM
admet-829	247	3	]	]	X
admet-829	247	4	r.c	r.c	PROPN
admet-829	247	5	.	.	PROPN
admet-829	247	6	heading	heading	PROPN
admet-829	247	7	,	,	PUNCT
admet-829	247	8	j.	j.	PROPN
admet-829	247	9	nimmo	nimmo	PROPN
admet-829	247	10	,	,	PUNCT
admet-829	247	11	l.f	l.f	PROPN
admet-829	247	12	.	.	PROPN
admet-829	247	13	prescott	prescott	PROPN
admet-829	247	14	,	,	PUNCT
admet-829	247	15	p.	p.	NOUN
admet-829	247	16	tothill	tothill	NOUN
admet-829	247	17	.	.	PUNCT
admet-829	248	1	the	the	DET
admet-829	248	2	dependence	dependence	NOUN
admet-829	248	3	of	of	ADP
admet-829	248	4	paracetamol	paracetamol	NOUN
admet-829	248	5	absorption	absorption	NOUN
admet-829	248	6	on	on	ADP
admet-829	248	7	the	the	DET
admet-829	248	8	rate	rate	NOUN
admet-829	248	9	of	of	ADP
admet-829	248	10	gastric	gastric	ADJ
admet-829	248	11	emptying	emptying	NOUN
admet-829	248	12	.	.	PUNCT
admet-829	249	1	br	br	PROPN
admet-829	249	2	.	.	PUNCT
admet-829	250	1	j.	j.	PROPN
admet-829	250	2	pharmacol	pharmacol	PROPN
admet-829	250	3	.	.	PUNCT
admet-829	251	1	47	47	NUM
admet-829	251	2	(	(	PUNCT
admet-829	251	3	1973	1973	NUM
admet-829	251	4	)	)	PUNCT
admet-829	251	5	415	415	NUM
admet-829	251	6	-	-	SYM
admet-829	251	7	421	421	NUM
admet-829	251	8	.	.	PUNCT
admet-829	252	1	[	[	X
admet-829	252	2	18	18	NUM
admet-829	252	3	]	]	X
admet-829	252	4	w.s	w.s	PROPN
admet-829	252	5	.	.	PROPN
admet-829	252	6	nimmo	nimmo	PROPN
admet-829	252	7	,	,	PUNCT
admet-829	252	8	r.c	r.c	PROPN
admet-829	252	9	.	.	PROPN
admet-829	252	10	heading	heading	PROPN
admet-829	252	11	,	,	PUNCT
admet-829	252	12	j.	j.	PROPN
admet-829	252	13	wilson	wilson	PROPN
admet-829	252	14	,	,	PUNCT
admet-829	252	15	p.	p.	PROPN
admet-829	252	16	tothill	tothill	PROPN
admet-829	252	17	,	,	PUNCT
admet-829	252	18	l.f	l.f	PROPN
admet-829	252	19	.	.	PROPN
admet-829	252	20	prescott	prescott	PROPN
admet-829	252	21	.	.	PUNCT
admet-829	253	1	inhigition	inhigition	NOUN
admet-829	253	2	of	of	ADP
admet-829	253	3	gastric	gastric	ADJ
admet-829	253	4	emptying	empty	VERB
admet-829	253	5	and	and	CCONJ
admet-829	253	6	drug	drug	NOUN
admet-829	253	7	absorption	absorption	NOUN
admet-829	253	8	by	by	ADP
admet-829	253	9	narcotic	narcotic	ADJ
admet-829	253	10	analgesics	analgesic	NOUN
admet-829	253	11	.	.	PUNCT
admet-829	254	1	br	br	PROPN
admet-829	254	2	.	.	PUNCT
admet-829	255	1	j.	j.	PROPN
admet-829	255	2	clin	clin	PROPN
admet-829	255	3	.	.	PUNCT
admet-829	256	1	pharmacol	pharmacol	PROPN
admet-829	256	2	.	.	PROPN
admet-829	257	1	2	2	NUM
admet-829	257	2	(	(	PUNCT
admet-829	257	3	1975	1975	NUM
admet-829	257	4	)	)	PUNCT
admet-829	257	5	509	509	NUM
admet-829	257	6	-	-	SYM
admet-829	257	7	513	513	NUM
admet-829	257	8	.	.	PUNCT
admet-829	258	1	[	[	X
admet-829	258	2	19	19	NUM
admet-829	258	3	]	]	X
admet-829	258	4	p.a	p.a	PROPN
admet-829	258	5	.	.	PROPN
admet-829	258	6	dickinson	dickinson	PROPN
admet-829	258	7	,	,	PUNCT
admet-829	258	8	w.w	w.w	PROPN
admet-829	258	9	.	.	PROPN
admet-829	258	10	lee	lee	PROPN
admet-829	258	11	,	,	PUNCT
admet-829	258	12	p.w	p.w	PROPN
admet-829	258	13	.	.	PROPN
admet-829	258	14	stott	stott	PROPN
admet-829	258	15	,	,	PUNCT
admet-829	258	16	a.i	a.i	PROPN
admet-829	258	17	.	.	PROPN
admet-829	258	18	townsend	townsend	PROPN
admet-829	258	19	,	,	PUNCT
admet-829	258	20	j.p	j.p	PROPN
admet-829	258	21	.	.	PROPN
admet-829	258	22	smart	smart	PROPN
admet-829	258	23	,	,	PUNCT
admet-829	258	24	p.	p.	NOUN
admet-829	258	25	ghahramani	ghahramani	PROPN
admet-829	258	26	,	,	PUNCT
admet-829	258	27	t.	t.	PROPN
admet-829	258	28	hammett	hammett	PROPN
admet-829	258	29	,	,	PUNCT
admet-829	258	30	l.	l.	PROPN
admet-829	258	31	billett	billett	PROPN
admet-829	258	32	,	,	PUNCT
admet-829	258	33	s.	s.	PROPN
admet-829	258	34	behn	behn	PROPN
admet-829	258	35	,	,	PUNCT
admet-829	258	36	r.c	r.c	PROPN
admet-829	258	37	.	.	PROPN
admet-829	258	38	gibb	gibb	PROPN
admet-829	258	39	,	,	PUNCT
admet-829	258	40	b.	b.	PROPN
admet-829	258	41	abrahamsson	abrahamsson	PROPN
admet-829	258	42	.	.	PUNCT
admet-829	259	1	clinical	clinical	ADJ
admet-829	259	2	relevance	relevance	NOUN
admet-829	259	3	of	of	ADP
admet-829	259	4	dissolution	dissolution	ADJ
admet-829	259	5	testing	testing	NOUN
admet-829	259	6	in	in	ADP
admet-829	259	7	quality	quality	NOUN
admet-829	259	8	by	by	ADP
admet-829	259	9	design	design	NOUN
admet-829	259	10	.	.	PUNCT
admet-829	260	1	aaps	aap	NOUN
admet-829	260	2	j.	j.	PROPN
admet-829	260	3	10	10	NUM
admet-829	260	4	(	(	PUNCT
admet-829	260	5	2008	2008	NUM
admet-829	260	6	)	)	PUNCT
admet-829	260	7	380	380	NUM
admet-829	260	8	-	-	SYM
admet-829	260	9	390	390	NUM
admet-829	260	10	.	.	PUNCT
admet-829	261	1	©	©	PROPN
admet-829	261	2	2020	2020	NUM
admet-829	261	3	by	by	ADP
admet-829	261	4	the	the	DET
admet-829	261	5	authors	author	NOUN
admet-829	261	6	;	;	PUNCT
admet-829	261	7	licensee	licensee	PROPN
admet-829	261	8	iapc	iapc	PROPN
admet-829	261	9	,	,	PUNCT
admet-829	261	10	zagreb	zagreb	PROPN
admet-829	261	11	,	,	PUNCT
admet-829	261	12	croatia	croatia	PROPN
admet-829	261	13	.	.	PUNCT
admet-829	262	1	this	this	DET
admet-829	262	2	article	article	NOUN
admet-829	262	3	is	be	AUX
admet-829	262	4	an	an	DET
admet-829	262	5	open	open	ADJ
admet-829	262	6	-	-	PUNCT
admet-829	262	7	access	access	NOUN
admet-829	262	8	article	article	NOUN
admet-829	262	9	distributed	distribute	VERB
admet-829	262	10	under	under	ADP
admet-829	262	11	the	the	DET
admet-829	262	12	terms	term	NOUN
admet-829	262	13	and	and	CCONJ
admet-829	262	14	conditions	condition	NOUN
admet-829	262	15	of	of	ADP
admet-829	262	16	the	the	DET
admet-829	262	17	creative	creative	ADJ
admet-829	262	18	commons	common	NOUN
admet-829	262	19	attribution	attribution	NOUN
admet-829	262	20	license	license	NOUN
admet-829	262	21	(	(	PUNCT
admet-829	262	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-829	262	23	)	)	PUNCT
admet-829	262	24	http://dx.doi.org/10.5599/admet.829	http://dx.doi.org/10.5599/admet.829	PROPN
admet-829	262	25	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	X
admet-829	262	26	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	https://www.humanbiology.wzw.tum.de/index.php?id=22&l=1	X
admet-829	262	27	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN