id	sid	tid	token	lemma	pos
admet-830	1	1	the	the	DET
admet-830	1	2	effect	effect	NOUN
admet-830	1	3	of	of	ADP
admet-830	1	4	drug	drug	NOUN
admet-830	1	5	ionization	ionization	NOUN
admet-830	1	6	on	on	ADP
admet-830	1	7	lipid	lipid	NOUN
admet-830	1	8	-	-	PUNCT
admet-830	1	9	lased	lase	VERB
admet-830	1	10	formulations	formulation	NOUN
admet-830	1	11	for	for	ADP
admet-830	1	12	the	the	DET
admet-830	1	13	oral	oral	ADJ
admet-830	1	14	delivery	delivery	NOUN
admet-830	1	15	of	of	ADP
admet-830	1	16	anti	anti	ADJ
admet-830	1	17	-	-	ADJ
admet-830	1	18	psychotics	psychotic	NOUN
admet-830	1	19	doi	doi	NOUN
admet-830	1	20	:	:	PUNCT
admet-830	1	21	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	1	22	437	437	NUM
admet-830	1	23	admet	admet	X
admet-830	1	24	&	&	CCONJ
admet-830	1	25	dmpk	dmpk	PROPN
admet-830	1	26	8(4	8(4	NOUN
admet-830	1	27	)	)	PUNCT
admet-830	1	28	(	(	PUNCT
admet-830	1	29	2020	2020	NUM
admet-830	1	30	)	)	PUNCT
admet-830	1	31	437	437	NUM
admet-830	1	32	-	-	SYM
admet-830	1	33	451	451	NUM
admet-830	1	34	;	;	PUNCT
admet-830	1	35	doi	doi	NOUN
admet-830	1	36	:	:	PUNCT
admet-830	1	37	https://doi.org/10.5599/admet.830	https://doi.org/10.5599/admet.830	NOUN
admet-830	1	38	open	open	ADJ
admet-830	1	39	access	access	NOUN
admet-830	1	40	:	:	PUNCT
admet-830	1	41	issn	issn	PROPN
admet-830	1	42	:	:	PUNCT
admet-830	1	43	1848	1848	NUM
admet-830	1	44	-	-	SYM
admet-830	1	45	7718	7718	NUM
admet-830	1	46	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-830	1	47	original	original	ADJ
admet-830	1	48	scientific	scientific	ADJ
admet-830	1	49	paper	paper	NOUN
admet-830	1	50	the	the	DET
admet-830	1	51	effect	effect	NOUN
admet-830	1	52	of	of	ADP
admet-830	1	53	drug	drug	NOUN
admet-830	1	54	ionization	ionization	NOUN
admet-830	1	55	on	on	ADP
admet-830	1	56	lipid	lipid	NOUN
admet-830	1	57	-	-	PUNCT
admet-830	1	58	based	base	VERB
admet-830	1	59	formulations	formulation	NOUN
admet-830	1	60	for	for	ADP
admet-830	1	61	the	the	DET
admet-830	1	62	oral	oral	ADJ
admet-830	1	63	delivery	delivery	NOUN
admet-830	1	64	of	of	ADP
admet-830	1	65	anti	anti	ADJ
admet-830	1	66	-	-	ADJ
admet-830	1	67	psychotics	psychotic	NOUN
admet-830	1	68	tahlia	tahlia	PROPN
admet-830	1	69	r	r	PROPN
admet-830	1	70	meola	meola	PROPN
admet-830	1	71	#	#	NOUN
admet-830	1	72	,	,	PUNCT
admet-830	1	73	kara	kara	PROPN
admet-830	1	74	paxton	paxton	PROPN
admet-830	1	75	#	#	PROPN
admet-830	1	76	,	,	PUNCT
admet-830	1	77	paul	paul	PROPN
admet-830	1	78	joyce	joyce	PROPN
admet-830	1	79	,	,	PUNCT
admet-830	1	80	hayley	hayley	PROPN
admet-830	1	81	b	b	PROPN
admet-830	1	82	schultz	schultz	PROPN
admet-830	1	83	,	,	PUNCT
admet-830	1	84	and	and	CCONJ
admet-830	1	85	clive	clive	ADJ
admet-830	1	86	a	a	DET
admet-830	1	87	prestidge	prestidge	NOUN
admet-830	1	88	*	*	SYM
admet-830	1	89	1	1	NUM
admet-830	1	90	unisa	unisa	NOUN
admet-830	1	91	:	:	PUNCT
admet-830	1	92	clinical	clinical	ADJ
admet-830	1	93	and	and	CCONJ
admet-830	1	94	health	health	NOUN
admet-830	1	95	sciences	science	NOUN
admet-830	1	96	,	,	PUNCT
admet-830	1	97	university	university	NOUN
admet-830	1	98	of	of	ADP
admet-830	1	99	south	south	PROPN
admet-830	1	100	australia	australia	PROPN
admet-830	1	101	,	,	PUNCT
admet-830	1	102	city	city	PROPN
admet-830	1	103	west	west	PROPN
admet-830	1	104	campus	campus	PROPN
admet-830	1	105	,	,	PUNCT
admet-830	1	106	adelaide	adelaide	PROPN
admet-830	1	107	,	,	PUNCT
admet-830	1	108	south	south	PROPN
admet-830	1	109	australia	australia	PROPN
admet-830	1	110	5000	5000	NUM
admet-830	1	111	,	,	PUNCT
admet-830	1	112	australia	australia	PROPN
admet-830	1	113	2	2	NUM
admet-830	1	114	arc	arc	NOUN
admet-830	1	115	centre	centre	NOUN
admet-830	1	116	of	of	ADP
admet-830	1	117	excellence	excellence	PROPN
admet-830	1	118	in	in	ADP
admet-830	1	119	convergent	convergent	NOUN
admet-830	1	120	bio	bio	PROPN
admet-830	1	121	-	-	ADJ
admet-830	1	122	nano	nano	ADJ
admet-830	1	123	science	science	NOUN
admet-830	1	124	&	&	CCONJ
admet-830	1	125	technology	technology	PROPN
admet-830	1	126	,	,	PUNCT
admet-830	1	127	university	university	NOUN
admet-830	1	128	of	of	ADP
admet-830	1	129	south	south	PROPN
admet-830	1	130	australia	australia	PROPN
admet-830	1	131	,	,	PUNCT
admet-830	1	132	city	city	PROPN
admet-830	1	133	west	west	PROPN
admet-830	1	134	campus	campus	PROPN
admet-830	1	135	,	,	PUNCT
admet-830	1	136	adelaide	adelaide	PROPN
admet-830	1	137	,	,	PUNCT
admet-830	1	138	south	south	PROPN
admet-830	1	139	australia	australia	PROPN
admet-830	1	140	5000	5000	NUM
admet-830	1	141	,	,	PUNCT
admet-830	1	142	australia	australia	PROPN
admet-830	1	143	#	#	NOUN
admet-830	1	144	tahlia	tahlia	PROPN
admet-830	1	145	r	r	NOUN
admet-830	1	146	meola	meola	PROPN
admet-830	1	147	and	and	CCONJ
admet-830	1	148	kara	kara	PROPN
admet-830	1	149	paxton	paxton	PROPN
admet-830	1	150	contributed	contribute	VERB
admet-830	1	151	equally	equally	ADV
admet-830	1	152	to	to	ADP
admet-830	1	153	this	this	DET
admet-830	1	154	experimental	experimental	ADJ
admet-830	1	155	research	research	NOUN
admet-830	1	156	.	.	PUNCT
admet-830	2	1	*	*	PUNCT
admet-830	2	2	corresponding	correspond	VERB
admet-830	2	3	author	author	NOUN
admet-830	2	4	:	:	PUNCT
admet-830	2	5	e	e	NOUN
admet-830	2	6	-	-	NOUN
admet-830	2	7	mail	mail	NOUN
admet-830	2	8	:	:	PUNCT
admet-830	2	9	clive.prestidge@unisa.edu.au	clive.prestidge@unisa.edu.au	PROPN
admet-830	2	10	;	;	PUNCT
admet-830	2	11	tel	tel	PROPN
admet-830	2	12	.	.	PUNCT
admet-830	2	13	:	:	PUNCT
admet-830	2	14	+61	+61	NOUN
admet-830	2	15	8	8	NUM
admet-830	2	16	830	830	NUM
admet-830	2	17	22438	22438	NUM
admet-830	2	18	;	;	PUNCT
admet-830	2	19	fax	fax	NOUN
admet-830	2	20	:	:	PUNCT
admet-830	2	21	+61	+61	NOUN
admet-830	2	22	8	8	NUM
admet-830	2	23	8302	8302	NUM
admet-830	2	24	2389	2389	NUM
admet-830	2	25	received	receive	VERB
admet-830	2	26	:	:	PUNCT
admet-830	2	27	april	april	PROPN
admet-830	2	28	21	21	NUM
admet-830	2	29	,	,	PUNCT
admet-830	2	30	2020	2020	NUM
admet-830	2	31	;	;	PUNCT
admet-830	2	32	revised	revise	VERB
admet-830	2	33	:	:	PUNCT
admet-830	2	34	july	july	PROPN
admet-830	2	35	15	15	NUM
admet-830	2	36	,	,	PUNCT
admet-830	2	37	2020	2020	NUM
admet-830	2	38	;	;	PUNCT
admet-830	2	39	published	publish	VERB
admet-830	2	40	:	:	PUNCT
admet-830	2	41	july	july	PROPN
admet-830	2	42	17	17	NUM
admet-830	2	43	,	,	PUNCT
admet-830	2	44	2020	2020	NUM
admet-830	2	45	abstract	abstract	ADJ
admet-830	2	46	lipid	lipid	NOUN
admet-830	2	47	-	-	PUNCT
admet-830	2	48	based	base	VERB
admet-830	2	49	formulations	formulation	NOUN
admet-830	2	50	(	(	PUNCT
admet-830	2	51	lbfs	lbfs	NOUN
admet-830	2	52	)	)	PUNCT
admet-830	2	53	are	be	AUX
admet-830	2	54	well	well	ADV
admet-830	2	55	-	-	PUNCT
admet-830	2	56	known	know	VERB
admet-830	2	57	to	to	PART
admet-830	2	58	improve	improve	VERB
admet-830	2	59	the	the	DET
admet-830	2	60	oral	oral	ADJ
admet-830	2	61	bioavailability	bioavailability	NOUN
admet-830	2	62	of	of	ADP
admet-830	2	63	poorly	poorly	ADV
admet-830	2	64	water	water	NOUN
admet-830	2	65	-	-	PUNCT
admet-830	2	66	soluble	soluble	ADJ
admet-830	2	67	drugs	drug	NOUN
admet-830	2	68	(	(	PUNCT
admet-830	2	69	pwsds	pwsds	NOUN
admet-830	2	70	)	)	PUNCT
admet-830	2	71	by	by	ADP
admet-830	2	72	presenting	present	VERB
admet-830	2	73	the	the	DET
admet-830	2	74	drug	drug	NOUN
admet-830	2	75	to	to	ADP
admet-830	2	76	the	the	DET
admet-830	2	77	gastrointestinal	gastrointestinal	ADJ
admet-830	2	78	environment	environment	NOUN
admet-830	2	79	in	in	ADP
admet-830	2	80	a	a	DET
admet-830	2	81	molecularly	molecularly	ADV
admet-830	2	82	dispersed	disperse	VERB
admet-830	2	83	state	state	NOUN
admet-830	2	84	,	,	PUNCT
admet-830	2	85	thus	thus	ADV
admet-830	2	86	avoiding	avoid	VERB
admet-830	2	87	the	the	DET
admet-830	2	88	rate	rate	NOUN
admet-830	2	89	-	-	PUNCT
admet-830	2	90	limiting	limit	VERB
admet-830	2	91	dissolution	dissolution	NOUN
admet-830	2	92	step	step	NOUN
admet-830	2	93	.	.	PUNCT
admet-830	3	1	risperidone	risperidone	NOUN
admet-830	3	2	and	and	CCONJ
admet-830	3	3	lurasidone	lurasidone	NOUN
admet-830	3	4	are	be	AUX
admet-830	3	5	antipsychotics	antipsychotic	NOUN
admet-830	3	6	drugs	drug	NOUN
admet-830	3	7	which	which	PRON
admet-830	3	8	experience	experience	VERB
admet-830	3	9	erratic	erratic	ADJ
admet-830	3	10	and	and	CCONJ
admet-830	3	11	variable	variable	ADJ
admet-830	3	12	absorption	absorption	NOUN
admet-830	3	13	,	,	PUNCT
admet-830	3	14	leading	lead	VERB
admet-830	3	15	to	to	ADP
admet-830	3	16	a	a	DET
admet-830	3	17	low	low	ADJ
admet-830	3	18	oral	oral	ADJ
admet-830	3	19	bioavailability	bioavailability	NOUN
admet-830	3	20	.	.	PUNCT
admet-830	4	1	the	the	DET
admet-830	4	2	aim	aim	NOUN
admet-830	4	3	of	of	ADP
admet-830	4	4	this	this	DET
admet-830	4	5	research	research	NOUN
admet-830	4	6	was	be	AUX
admet-830	4	7	to	to	PART
admet-830	4	8	develop	develop	VERB
admet-830	4	9	and	and	CCONJ
admet-830	4	10	investigate	investigate	VERB
admet-830	4	11	the	the	DET
admet-830	4	12	performance	performance	NOUN
admet-830	4	13	of	of	ADP
admet-830	4	14	risperidone	risperidone	NOUN
admet-830	4	15	and	and	CCONJ
admet-830	4	16	lurasidone	lurasidone	NOUN
admet-830	4	17	when	when	SCONJ
admet-830	4	18	formulated	formulate	VERB
admet-830	4	19	as	as	ADP
admet-830	4	20	an	an	DET
admet-830	4	21	emulsion	emulsion	NOUN
admet-830	4	22	and	and	CCONJ
admet-830	4	23	silica	silica	NOUN
admet-830	4	24	-	-	PUNCT
admet-830	4	25	lipid	lipid	NOUN
admet-830	4	26	hybrid	hybrid	NOUN
admet-830	4	27	(	(	PUNCT
admet-830	4	28	slh	slh	PROPN
admet-830	4	29	)	)	PUNCT
admet-830	4	30	.	.	PUNCT
admet-830	5	1	lurasidone	lurasidone	NOUN
admet-830	5	2	and	and	CCONJ
admet-830	5	3	risperidone	risperidone	NOUN
admet-830	5	4	were	be	AUX
admet-830	5	5	dissolved	dissolve	VERB
admet-830	5	6	in	in	ADP
admet-830	5	7	capmul	capmul	PROPN
admet-830	5	8	®	®	PROPN
admet-830	5	9	mcm	mcm	PROPN
admet-830	5	10	at	at	ADP
admet-830	5	11	100	100	NUM
admet-830	5	12	%	%	NOUN
admet-830	5	13	and	and	CCONJ
admet-830	5	14	80	80	NUM
admet-830	5	15	%	%	NOUN
admet-830	5	16	their	their	PRON
admet-830	5	17	equilibrium	equilibrium	NOUN
admet-830	5	18	solubility	solubility	NOUN
admet-830	5	19	,	,	PUNCT
admet-830	5	20	respectively	respectively	ADV
admet-830	5	21	,	,	PUNCT
admet-830	5	22	prior	prior	ADV
admet-830	5	23	to	to	ADP
admet-830	5	24	forming	form	VERB
admet-830	5	25	a	a	DET
admet-830	5	26	sub	sub	ADJ
admet-830	5	27	-	-	ADJ
admet-830	5	28	micron	micron	ADJ
admet-830	5	29	emulsion	emulsion	NOUN
admet-830	5	30	.	.	PUNCT
admet-830	6	1	slh	slh	PROPN
admet-830	6	2	microparticles	microparticle	NOUN
admet-830	6	3	were	be	AUX
admet-830	6	4	fabricated	fabricate	VERB
admet-830	6	5	by	by	ADP
admet-830	6	6	spray	spray	NOUN
admet-830	6	7	-	-	PUNCT
admet-830	6	8	drying	dry	VERB
admet-830	6	9	a	a	DET
admet-830	6	10	silica	silica	NOUN
admet-830	6	11	stabilised	stabilise	VERB
admet-830	6	12	sub	sub	ADJ
admet-830	6	13	-	-	ADJ
admet-830	6	14	micron	micron	ADJ
admet-830	6	15	emulsion	emulsion	NOUN
admet-830	6	16	to	to	PART
admet-830	6	17	form	form	VERB
admet-830	6	18	a	a	DET
admet-830	6	19	solid	solid	ADJ
admet-830	6	20	powder	powder	NOUN
admet-830	6	21	.	.	PUNCT
admet-830	7	1	the	the	DET
admet-830	7	2	performances	performance	NOUN
admet-830	7	3	of	of	ADP
admet-830	7	4	the	the	DET
admet-830	7	5	formulations	formulation	NOUN
admet-830	7	6	were	be	AUX
admet-830	7	7	evaluated	evaluate	VERB
admet-830	7	8	in	in	ADP
admet-830	7	9	simulated	simulated	ADJ
admet-830	7	10	intestinal	intestinal	ADJ
admet-830	7	11	media	medium	NOUN
admet-830	7	12	under	under	ADP
admet-830	7	13	digesting	digest	VERB
admet-830	7	14	conditions	condition	NOUN
admet-830	7	15	,	,	PUNCT
admet-830	7	16	where	where	SCONJ
admet-830	7	17	the	the	DET
admet-830	7	18	emulsion	emulsion	NOUN
admet-830	7	19	and	and	CCONJ
admet-830	7	20	slh	slh	PROPN
admet-830	7	21	provided	provide	VERB
admet-830	7	22	a	a	DET
admet-830	7	23	17	17	NUM
admet-830	7	24	-	-	ADJ
admet-830	7	25	fold	fold	ADJ
admet-830	7	26	and	and	CCONJ
admet-830	7	27	23	23	NUM
admet-830	7	28	-	-	ADJ
admet-830	7	29	fold	fold	ADJ
admet-830	7	30	increase	increase	NOUN
admet-830	7	31	in	in	ADP
admet-830	7	32	lur	lur	PROPN
admet-830	7	33	solubilisation	solubilisation	NOUN
admet-830	7	34	,	,	PUNCT
admet-830	7	35	respectively	respectively	ADV
admet-830	7	36	.	.	PUNCT
admet-830	8	1	however	however	ADV
admet-830	8	2	,	,	PUNCT
admet-830	8	3	the	the	DET
admet-830	8	4	performance	performance	NOUN
admet-830	8	5	of	of	ADP
admet-830	8	6	ris	ris	PROPN
admet-830	8	7	was	be	AUX
admet-830	8	8	reduced	reduce	VERB
admet-830	8	9	by	by	ADP
admet-830	8	10	2.2	2.2	NUM
admet-830	8	11	-	-	NOUN
admet-830	8	12	fold	fold	NOUN
admet-830	8	13	when	when	SCONJ
admet-830	8	14	encapsulated	encapsulate	VERB
admet-830	8	15	within	within	ADP
admet-830	8	16	slh	slh	NOUN
admet-830	8	17	compared	compare	VERB
admet-830	8	18	to	to	ADP
admet-830	8	19	pure	pure	ADJ
admet-830	8	20	drug	drug	NOUN
admet-830	8	21	.	.	PUNCT
admet-830	9	1	owing	owe	VERB
admet-830	9	2	to	to	ADP
admet-830	9	3	its	its	PRON
admet-830	9	4	pka	pka	PROPN
admet-830	9	5	,	,	PUNCT
admet-830	9	6	ris	ris	PROPN
admet-830	9	7	adsorbed	adsorb	VERB
admet-830	9	8	to	to	ADP
admet-830	9	9	the	the	DET
admet-830	9	10	silica	silica	NOUN
admet-830	9	11	and	and	CCONJ
admet-830	9	12	thus	thus	ADV
admet-830	9	13	,	,	PUNCT
admet-830	9	14	dissolution	dissolution	PROPN
admet-830	9	15	was	be	AUX
admet-830	9	16	significantly	significantly	ADV
admet-830	9	17	hindered	hinder	VERB
admet-830	9	18	.	.	PUNCT
admet-830	10	1	the	the	DET
admet-830	10	2	results	result	NOUN
admet-830	10	3	reveal	reveal	VERB
admet-830	10	4	that	that	SCONJ
admet-830	10	5	lbfs	lbfs	NOUN
admet-830	10	6	may	may	AUX
admet-830	10	7	not	not	PART
admet-830	10	8	overcome	overcome	VERB
admet-830	10	9	the	the	DET
admet-830	10	10	challenges	challenge	NOUN
admet-830	10	11	of	of	ADP
admet-830	10	12	all	all	DET
admet-830	10	13	pwsds	pwsds	ADJ
admet-830	10	14	and	and	CCONJ
admet-830	10	15	physiochemical	physiochemical	ADJ
admet-830	10	16	properties	property	NOUN
admet-830	10	17	must	must	AUX
admet-830	10	18	be	be	AUX
admet-830	10	19	carefully	carefully	ADV
admet-830	10	20	considered	consider	VERB
admet-830	10	21	when	when	SCONJ
admet-830	10	22	predicting	predict	VERB
admet-830	10	23	drug	drug	NOUN
admet-830	10	24	performance	performance	NOUN
admet-830	10	25	.	.	PUNCT
admet-830	11	1	©	©	PROPN
admet-830	11	2	2020	2020	NUM
admet-830	11	3	by	by	ADP
admet-830	11	4	the	the	DET
admet-830	11	5	authors	author	NOUN
admet-830	11	6	.	.	PUNCT
admet-830	12	1	this	this	DET
admet-830	12	2	article	article	NOUN
admet-830	12	3	is	be	AUX
admet-830	12	4	an	an	DET
admet-830	12	5	open	open	ADJ
admet-830	12	6	-	-	PUNCT
admet-830	12	7	access	access	NOUN
admet-830	12	8	article	article	NOUN
admet-830	12	9	distributed	distribute	VERB
admet-830	12	10	under	under	ADP
admet-830	12	11	the	the	DET
admet-830	12	12	terms	term	NOUN
admet-830	12	13	and	and	CCONJ
admet-830	12	14	conditions	condition	NOUN
admet-830	12	15	of	of	ADP
admet-830	12	16	the	the	DET
admet-830	12	17	creative	creative	ADJ
admet-830	12	18	commons	common	NOUN
admet-830	12	19	attribution	attribution	NOUN
admet-830	12	20	license	license	NOUN
admet-830	12	21	(	(	PUNCT
admet-830	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-830	12	23	)	)	PUNCT
admet-830	12	24	.	.	PUNCT
admet-830	13	1	keywords	keyword	NOUN
admet-830	13	2	silica	silica	NOUN
admet-830	13	3	;	;	PUNCT
admet-830	13	4	nanoparticles	nanoparticle	NOUN
admet-830	13	5	;	;	PUNCT
admet-830	13	6	lurasidone	lurasidone	NOUN
admet-830	13	7	;	;	PUNCT
admet-830	13	8	risperidone	risperidone	NOUN
admet-830	13	9	;	;	PUNCT
admet-830	13	10	pka	pka	NOUN
admet-830	13	11	;	;	PUNCT
admet-830	13	12	precipitation	precipitation	NOUN
admet-830	13	13	;	;	PUNCT
admet-830	13	14	interactions	interaction	NOUN
admet-830	13	15	;	;	PUNCT
admet-830	13	16	dissolution	dissolution	NOUN
admet-830	13	17	;	;	PUNCT
admet-830	13	18	lipolysis	lipolysis	NOUN
admet-830	13	19	introduction	introduction	NOUN
admet-830	13	20	adherence	adherence	NOUN
admet-830	13	21	to	to	ADP
admet-830	13	22	antipsychotic	antipsychotic	ADJ
admet-830	13	23	medication	medication	NOUN
admet-830	13	24	is	be	AUX
admet-830	13	25	a	a	DET
admet-830	13	26	significant	significant	ADJ
admet-830	13	27	challenge	challenge	NOUN
admet-830	13	28	for	for	ADP
admet-830	13	29	patients	patient	NOUN
admet-830	13	30	,	,	PUNCT
admet-830	13	31	whereby	whereby	SCONJ
admet-830	13	32	research	research	NOUN
admet-830	13	33	suggests	suggest	VERB
admet-830	13	34	at	at	ADP
admet-830	13	35	least	least	ADJ
admet-830	13	36	half	half	NOUN
admet-830	13	37	of	of	ADP
admet-830	13	38	patients	patient	NOUN
admet-830	13	39	are	be	AUX
admet-830	13	40	non	non	ADJ
admet-830	13	41	-	-	ADJ
admet-830	13	42	compliant	compliant	ADJ
admet-830	13	43	,	,	PUNCT
admet-830	13	44	leading	lead	VERB
admet-830	13	45	to	to	ADP
admet-830	13	46	illness	illness	NOUN
admet-830	13	47	relapse	relapse	NOUN
admet-830	13	48	,	,	PUNCT
admet-830	13	49	hospital	hospital	NOUN
admet-830	13	50	remittance	remittance	NOUN
admet-830	13	51	or	or	CCONJ
admet-830	13	52	suicide	suicide	NOUN
admet-830	13	53	[	[	X
admet-830	13	54	1	1	NUM
admet-830	13	55	]	]	PUNCT
admet-830	13	56	.	.	PUNCT
admet-830	14	1	due	due	ADP
admet-830	14	2	to	to	ADP
admet-830	14	3	the	the	DET
admet-830	14	4	chronic	chronic	ADJ
admet-830	14	5	nature	nature	NOUN
admet-830	14	6	of	of	ADP
admet-830	14	7	schizophrenia	schizophrenia	NOUN
admet-830	14	8	,	,	PUNCT
admet-830	14	9	the	the	DET
admet-830	14	10	oral	oral	ADJ
admet-830	14	11	route	route	NOUN
admet-830	14	12	of	of	ADP
admet-830	14	13	administration	administration	NOUN
admet-830	14	14	is	be	AUX
admet-830	14	15	preferred	prefer	VERB
admet-830	14	16	.	.	PUNCT
admet-830	15	1	however	however	ADV
admet-830	15	2	,	,	PUNCT
admet-830	15	3	as	as	ADP
admet-830	15	4	a	a	DET
admet-830	15	5	class	class	NOUN
admet-830	15	6	,	,	PUNCT
admet-830	15	7	antipsychotic	antipsychotic	ADJ
admet-830	15	8	drugs	drug	NOUN
admet-830	15	9	are	be	AUX
admet-830	15	10	generally	generally	ADV
admet-830	15	11	poorly	poorly	ADV
admet-830	15	12	water	water	NOUN
admet-830	15	13	-	-	PUNCT
admet-830	15	14	soluble	soluble	ADJ
admet-830	15	15	,	,	PUNCT
admet-830	15	16	resulting	result	VERB
admet-830	15	17	in	in	ADP
admet-830	15	18	limited	limited	ADJ
admet-830	15	19	absorption	absorption	NOUN
admet-830	15	20	and	and	CCONJ
admet-830	15	21	sub	sub	ADJ
admet-830	15	22	-	-	ADJ
admet-830	15	23	optimal	optimal	ADJ
admet-830	15	24	oral	oral	ADJ
admet-830	15	25	bioavailability	bioavailability	NOUN
admet-830	15	26	when	when	SCONJ
admet-830	15	27	administered	administer	VERB
admet-830	15	28	as	as	ADP
admet-830	15	29	a	a	DET
admet-830	15	30	conventional	conventional	ADJ
admet-830	15	31	tablet	tablet	NOUN
admet-830	15	32	[	[	X
admet-830	15	33	2	2	NUM
admet-830	15	34	,	,	PUNCT
admet-830	15	35	3	3	NUM
admet-830	15	36	]	]	PUNCT
admet-830	15	37	.	.	PUNCT
admet-830	16	1	the	the	DET
admet-830	16	2	ability	ability	NOUN
admet-830	16	3	of	of	ADP
admet-830	16	4	lipids	lipid	NOUN
admet-830	16	5	to	to	PART
admet-830	16	6	improve	improve	VERB
admet-830	16	7	the	the	DET
admet-830	16	8	oral	oral	ADJ
admet-830	16	9	absorption	absorption	NOUN
admet-830	16	10	and	and	CCONJ
admet-830	16	11	bioavailability	bioavailability	NOUN
admet-830	16	12	of	of	ADP
admet-830	16	13	poorly	poorly	ADV
admet-830	16	14	water	water	NOUN
admet-830	16	15	-	-	PUNCT
admet-830	16	16	soluble	soluble	ADJ
admet-830	16	17	drugs	drug	NOUN
admet-830	16	18	is	be	AUX
admet-830	16	19	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	16	20	https://doi.org/10.5599/admet.830	https://doi.org/10.5599/admet.830	NOUN
admet-830	16	21	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-830	16	22	mailto:clive.prestidge@unisa.edu.au	mailto:clive.prestidge@unisa.edu.au	PROPN
admet-830	16	23	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-830	16	24	admet	admet	PROPN
admet-830	16	25	&	&	CCONJ
admet-830	16	26	dmpk	dmpk	PROPN
admet-830	16	27	8(4	8(4	NOUN
admet-830	16	28	)	)	PUNCT
admet-830	16	29	(	(	PUNCT
admet-830	16	30	2020	2020	NUM
admet-830	16	31	)	)	PUNCT
admet-830	16	32	437	437	NUM
admet-830	16	33	-	-	SYM
admet-830	16	34	451	451	NUM
admet-830	16	35	drug	drug	NOUN
admet-830	16	36	ionisation	ionisation	NOUN
admet-830	16	37	and	and	CCONJ
admet-830	16	38	lipid	lipid	NOUN
admet-830	16	39	-	-	PUNCT
admet-830	16	40	based	base	VERB
admet-830	16	41	formulations	formulation	NOUN
admet-830	16	42	doi	doi	NOUN
admet-830	16	43	:	:	PUNCT
admet-830	16	44	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	16	45	438	438	NUM
admet-830	16	46	well	well	ADV
admet-830	16	47	-	-	PUNCT
admet-830	16	48	established	establish	VERB
admet-830	16	49	in	in	ADP
admet-830	16	50	literature	literature	NOUN
admet-830	16	51	[	[	X
admet-830	16	52	4	4	NUM
admet-830	16	53	,	,	PUNCT
admet-830	16	54	5	5	NUM
admet-830	16	55	]	]	PUNCT
admet-830	16	56	.	.	PUNCT
admet-830	17	1	the	the	DET
admet-830	17	2	enhanced	enhance	VERB
admet-830	17	3	performance	performance	NOUN
admet-830	17	4	provided	provide	VERB
admet-830	17	5	by	by	ADP
admet-830	17	6	lipid	lipid	NOUN
admet-830	17	7	-	-	PUNCT
admet-830	17	8	based	base	VERB
admet-830	17	9	formulations	formulation	NOUN
admet-830	17	10	(	(	PUNCT
admet-830	17	11	lbfs	lbfs	NOUN
admet-830	17	12	)	)	PUNCT
admet-830	17	13	can	can	AUX
admet-830	17	14	be	be	AUX
admet-830	17	15	attributed	attribute	VERB
admet-830	17	16	to	to	ADP
admet-830	17	17	the	the	DET
admet-830	17	18	following	follow	VERB
admet-830	17	19	proposed	propose	VERB
admet-830	17	20	mechanisms	mechanism	NOUN
admet-830	17	21	:	:	PUNCT
admet-830	17	22	(	(	PUNCT
admet-830	17	23	i	i	NOUN
admet-830	17	24	)	)	PUNCT
admet-830	17	25	lipids	lipid	VERB
admet-830	17	26	in	in	ADP
admet-830	17	27	the	the	DET
admet-830	17	28	gastrointestinal	gastrointestinal	ADJ
admet-830	17	29	tract	tract	NOUN
admet-830	17	30	hinder	hinder	NOUN
admet-830	17	31	gastric	gastric	ADJ
admet-830	17	32	emptying	empty	VERB
admet-830	17	33	from	from	ADP
admet-830	17	34	the	the	DET
admet-830	17	35	stomach	stomach	NOUN
admet-830	17	36	,	,	PUNCT
admet-830	17	37	therefore	therefore	ADV
admet-830	17	38	increase	increase	VERB
admet-830	17	39	transit	transit	NOUN
admet-830	17	40	time	time	NOUN
admet-830	17	41	of	of	ADP
admet-830	17	42	the	the	DET
admet-830	17	43	drug	drug	NOUN
admet-830	17	44	in	in	ADP
admet-830	17	45	the	the	DET
admet-830	17	46	small	small	ADJ
admet-830	17	47	intestine	intestine	NOUN
admet-830	17	48	,	,	PUNCT
admet-830	17	49	allowing	allow	VERB
admet-830	17	50	greater	great	ADJ
admet-830	17	51	absorption	absorption	NOUN
admet-830	17	52	to	to	PART
admet-830	17	53	occur	occur	VERB
admet-830	17	54	[	[	PUNCT
admet-830	17	55	6	6	NUM
admet-830	17	56	,	,	PUNCT
admet-830	17	57	7	7	NUM
admet-830	17	58	]	]	PUNCT
admet-830	17	59	;	;	PUNCT
admet-830	17	60	(	(	PUNCT
admet-830	17	61	ii	ii	NOUN
admet-830	17	62	)	)	PUNCT
admet-830	17	63	drug	drug	NOUN
admet-830	17	64	can	can	AUX
admet-830	17	65	be	be	AUX
admet-830	17	66	encapsulated	encapsulate	VERB
admet-830	17	67	and	and	CCONJ
admet-830	17	68	pre	pre	VERB
admet-830	17	69	-	-	VERB
admet-830	17	70	solubilised	solubilise	VERB
admet-830	17	71	in	in	ADP
admet-830	17	72	lipid	lipid	NOUN
admet-830	17	73	and	and	CCONJ
admet-830	17	74	presented	present	VERB
admet-830	17	75	to	to	ADP
admet-830	17	76	the	the	DET
admet-830	17	77	gastrointestinal	gastrointestinal	ADJ
admet-830	17	78	tract	tract	NOUN
admet-830	17	79	in	in	ADP
admet-830	17	80	its	its	PRON
admet-830	17	81	molecularly	molecularly	ADV
admet-830	17	82	dispersed	disperse	VERB
admet-830	17	83	state	state	NOUN
admet-830	17	84	,	,	PUNCT
admet-830	17	85	therefore	therefore	ADV
admet-830	17	86	drug	drug	NOUN
admet-830	17	87	absorption	absorption	NOUN
admet-830	17	88	is	be	AUX
admet-830	17	89	no	no	ADV
admet-830	17	90	longer	long	ADV
admet-830	17	91	limited	limit	VERB
admet-830	17	92	by	by	ADP
admet-830	17	93	its	its	PRON
admet-830	17	94	dissolution	dissolution	NOUN
admet-830	17	95	rate	rate	NOUN
admet-830	18	1	[	[	X
admet-830	18	2	8	8	NUM
admet-830	18	3	,	,	PUNCT
admet-830	18	4	9	9	NUM
admet-830	18	5	]	]	PUNCT
admet-830	18	6	,	,	PUNCT
admet-830	18	7	and	and	CCONJ
admet-830	18	8	(	(	PUNCT
admet-830	18	9	iii	iii	NOUN
admet-830	18	10	)	)	PUNCT
admet-830	18	11	exogenous	exogenous	ADJ
admet-830	18	12	lipids	lipid	NOUN
admet-830	18	13	stimulate	stimulate	VERB
admet-830	18	14	the	the	DET
admet-830	18	15	release	release	NOUN
admet-830	18	16	of	of	ADP
admet-830	18	17	bile	bile	NOUN
admet-830	18	18	and	and	CCONJ
admet-830	18	19	pancreatic	pancreatic	ADJ
admet-830	18	20	lipase	lipase	NOUN
admet-830	18	21	from	from	ADP
admet-830	18	22	the	the	DET
admet-830	18	23	gall	gall	NOUN
admet-830	18	24	bladder	bladder	NOUN
admet-830	18	25	and	and	CCONJ
admet-830	18	26	pancreas	pancrea	NOUN
admet-830	18	27	,	,	PUNCT
admet-830	18	28	respectively	respectively	ADV
admet-830	18	29	,	,	PUNCT
admet-830	18	30	which	which	PRON
admet-830	18	31	triggers	trigger	VERB
admet-830	18	32	the	the	DET
admet-830	18	33	production	production	NOUN
admet-830	18	34	of	of	ADP
admet-830	18	35	solubilising	solubilise	VERB
admet-830	18	36	species	specie	NOUN
admet-830	18	37	that	that	PRON
admet-830	18	38	can	can	AUX
admet-830	18	39	further	far	ADV
admet-830	18	40	solubilise	solubilise	VERB
admet-830	18	41	the	the	DET
admet-830	18	42	drug	drug	NOUN
admet-830	18	43	and	and	CCONJ
admet-830	18	44	be	be	AUX
admet-830	18	45	transported	transport	VERB
admet-830	18	46	across	across	ADP
admet-830	18	47	the	the	DET
admet-830	18	48	epithelium	epithelium	NOUN
admet-830	18	49	via	via	ADP
admet-830	18	50	enterocytes	enterocyte	NOUN
admet-830	18	51	[	[	X
admet-830	18	52	6	6	NUM
admet-830	18	53	,	,	PUNCT
admet-830	18	54	7	7	NUM
admet-830	18	55	]	]	PUNCT
admet-830	18	56	.	.	PUNCT
admet-830	19	1	despite	despite	SCONJ
admet-830	19	2	the	the	DET
admet-830	19	3	magnitude	magnitude	NOUN
admet-830	19	4	of	of	ADP
admet-830	19	5	advantages	advantage	NOUN
admet-830	19	6	,	,	PUNCT
admet-830	19	7	lbfs	lbfs	ADP
admet-830	19	8	account	account	NOUN
admet-830	19	9	for	for	ADP
admet-830	19	10	only	only	ADV
admet-830	19	11	2	2	NUM
admet-830	19	12	-	-	SYM
admet-830	19	13	4	4	NUM
admet-830	19	14	%	%	NOUN
admet-830	19	15	of	of	ADP
admet-830	19	16	commercialised	commercialise	VERB
admet-830	19	17	pharmaceutical	pharmaceutical	NOUN
admet-830	19	18	formulations	formulation	NOUN
admet-830	19	19	[	[	X
admet-830	19	20	10	10	NUM
admet-830	19	21	,	,	PUNCT
admet-830	19	22	11	11	NUM
admet-830	19	23	]	]	PUNCT
admet-830	19	24	.	.	PUNCT
admet-830	20	1	this	this	PRON
admet-830	20	2	is	be	AUX
admet-830	20	3	likely	likely	ADV
admet-830	20	4	attributed	attribute	VERB
admet-830	20	5	to	to	ADP
admet-830	20	6	disadvantages	disadvantage	NOUN
admet-830	20	7	associated	associate	VERB
admet-830	20	8	with	with	ADP
admet-830	20	9	their	their	PRON
admet-830	20	10	liquid	liquid	NOUN
admet-830	20	11	-	-	PUNCT
admet-830	20	12	state	state	NOUN
admet-830	20	13	,	,	PUNCT
admet-830	20	14	such	such	ADJ
admet-830	20	15	as	as	ADP
admet-830	20	16	poor	poor	ADJ
admet-830	20	17	physical	physical	ADJ
admet-830	20	18	stability	stability	NOUN
admet-830	20	19	,	,	PUNCT
admet-830	20	20	drug	drug	NOUN
admet-830	20	21	leakage	leakage	NOUN
admet-830	20	22	,	,	PUNCT
admet-830	20	23	oxidation	oxidation	NOUN
admet-830	20	24	of	of	ADP
admet-830	20	25	lipid	lipid	ADJ
admet-830	20	26	excipients	excipient	NOUN
admet-830	20	27	and	and	CCONJ
admet-830	20	28	drug	drug	NOUN
admet-830	20	29	precipitation	precipitation	NOUN
admet-830	20	30	[	[	X
admet-830	20	31	12	12	NUM
admet-830	20	32	,	,	PUNCT
admet-830	20	33	13	13	NUM
admet-830	20	34	]	]	PUNCT
admet-830	20	35	.	.	PUNCT
admet-830	21	1	silica	silica	NOUN
admet-830	21	2	-	-	PUNCT
admet-830	21	3	lipid	lipid	NOUN
admet-830	21	4	hybrid	hybrid	NOUN
admet-830	21	5	(	(	PUNCT
admet-830	21	6	slh	slh	NOUN
admet-830	21	7	)	)	PUNCT
admet-830	21	8	microparticles	microparticle	NOUN
admet-830	21	9	are	be	AUX
admet-830	21	10	a	a	DET
admet-830	21	11	solid	solid	ADJ
admet-830	21	12	-	-	PUNCT
admet-830	21	13	state	state	NOUN
admet-830	21	14	formulation	formulation	NOUN
admet-830	21	15	which	which	PRON
admet-830	21	16	encapsulates	encapsulate	VERB
admet-830	21	17	liquid	liquid	ADJ
admet-830	21	18	-	-	PUNCT
admet-830	21	19	lipid	lipid	NOUN
admet-830	21	20	within	within	ADP
admet-830	21	21	the	the	DET
admet-830	21	22	porous	porous	ADJ
admet-830	21	23	matrix	matrix	NOUN
admet-830	21	24	.	.	PUNCT
admet-830	22	1	slh	slh	PROPN
admet-830	22	2	were	be	AUX
admet-830	22	3	developed	develop	VERB
admet-830	22	4	to	to	PART
admet-830	22	5	overcome	overcome	VERB
admet-830	22	6	liquid	liquid	ADJ
admet-830	22	7	-	-	PUNCT
admet-830	22	8	state	state	NOUN
admet-830	22	9	limitations	limitation	NOUN
admet-830	22	10	by	by	ADP
admet-830	22	11	combining	combine	VERB
admet-830	22	12	the	the	DET
admet-830	22	13	solubilising	solubilising	ADJ
admet-830	22	14	effects	effect	NOUN
admet-830	22	15	of	of	ADP
admet-830	22	16	lipids	lipid	NOUN
admet-830	22	17	with	with	ADP
admet-830	22	18	the	the	DET
admet-830	22	19	stabilising	stabilise	VERB
admet-830	22	20	effects	effect	NOUN
admet-830	22	21	of	of	ADP
admet-830	22	22	silica	silica	NOUN
admet-830	22	23	nanoparticles	nanoparticle	NOUN
admet-830	22	24	,	,	PUNCT
admet-830	22	25	to	to	PART
admet-830	22	26	provide	provide	VERB
admet-830	22	27	enhanced	enhanced	ADJ
admet-830	22	28	physical	physical	ADJ
admet-830	22	29	stability	stability	NOUN
admet-830	22	30	and	and	CCONJ
admet-830	22	31	superior	superior	ADJ
admet-830	22	32	performance	performance	NOUN
admet-830	22	33	[	[	X
admet-830	22	34	14	14	NUM
admet-830	22	35	]	]	PUNCT
admet-830	22	36	.	.	PUNCT
admet-830	23	1	this	this	DET
admet-830	23	2	lbf	lbf	PROPN
admet-830	23	3	has	have	AUX
admet-830	23	4	proven	prove	VERB
admet-830	23	5	successful	successful	ADJ
admet-830	23	6	for	for	ADP
admet-830	23	7	numerous	numerous	ADJ
admet-830	23	8	poorly	poorly	ADV
admet-830	23	9	water	water	NOUN
admet-830	23	10	-	-	PUNCT
admet-830	23	11	soluble	soluble	ADJ
admet-830	23	12	compounds	compound	NOUN
admet-830	23	13	such	such	ADJ
admet-830	23	14	as	as	ADP
admet-830	23	15	ibuprofen	ibuprofen	NOUN
admet-830	23	16	,	,	PUNCT
admet-830	23	17	celecoxib	celecoxib	NOUN
admet-830	23	18	,	,	PUNCT
admet-830	23	19	abiraterone	abiraterone	NOUN
admet-830	23	20	acetate	acetate	NOUN
admet-830	23	21	and	and	CCONJ
admet-830	23	22	simvastatin	simvastatin	NOUN
admet-830	23	23	[	[	X
admet-830	23	24	15	15	NUM
admet-830	23	25	-	-	SYM
admet-830	23	26	18	18	NUM
admet-830	23	27	]	]	PUNCT
admet-830	23	28	.	.	PUNCT
admet-830	24	1	slh	slh	PROPN
admet-830	24	2	microparticles	microparticle	NOUN
admet-830	24	3	are	be	AUX
admet-830	24	4	fabricated	fabricate	VERB
admet-830	24	5	by	by	ADP
admet-830	24	6	spray	spray	NOUN
admet-830	24	7	-	-	PUNCT
admet-830	24	8	drying	dry	VERB
admet-830	24	9	a	a	DET
admet-830	24	10	silica	silica	NOUN
admet-830	24	11	nanoparticle	nanoparticle	NOUN
admet-830	24	12	-	-	PUNCT
admet-830	24	13	stabilised	stabilise	VERB
admet-830	24	14	pickering	pickering	NOUN
admet-830	24	15	emulsion	emulsion	NOUN
admet-830	24	16	to	to	PART
admet-830	24	17	form	form	VERB
admet-830	24	18	a	a	DET
admet-830	24	19	solid	solid	ADJ
admet-830	24	20	nanostructured	nanostructure	VERB
admet-830	24	21	powder	powder	NOUN
admet-830	24	22	.	.	PUNCT
admet-830	25	1	owing	owe	VERB
admet-830	25	2	to	to	ADP
admet-830	25	3	a	a	DET
admet-830	25	4	highly	highly	ADV
admet-830	25	5	porous	porous	ADJ
admet-830	25	6	matrix	matrix	NOUN
admet-830	25	7	,	,	PUNCT
admet-830	25	8	lipase	lipase	NOUN
admet-830	25	9	enzymes	enzyme	NOUN
admet-830	25	10	can	can	AUX
admet-830	25	11	readily	readily	ADV
admet-830	25	12	digest	digest	VERB
admet-830	25	13	the	the	DET
admet-830	25	14	lipid	lipid	NOUN
admet-830	25	15	,	,	PUNCT
admet-830	25	16	thus	thus	ADV
admet-830	25	17	promoting	promote	VERB
admet-830	25	18	drug	drug	NOUN
admet-830	25	19	release	release	NOUN
admet-830	25	20	and	and	CCONJ
admet-830	25	21	absorption	absorption	NOUN
admet-830	25	22	[	[	X
admet-830	25	23	19	19	NUM
admet-830	25	24	]	]	PUNCT
admet-830	25	25	.	.	PUNCT
admet-830	26	1	lurasidone	lurasidone	NOUN
admet-830	26	2	(	(	PUNCT
admet-830	26	3	lur	lur	PROPN
admet-830	26	4	)	)	PUNCT
admet-830	26	5	and	and	CCONJ
admet-830	26	6	risperidone	risperidone	NOUN
admet-830	26	7	(	(	PUNCT
admet-830	26	8	ris	ris	PROPN
admet-830	26	9	)	)	PUNCT
admet-830	26	10	are	be	AUX
admet-830	26	11	two	two	NUM
admet-830	26	12	orally	orally	ADV
admet-830	26	13	administered	administer	VERB
admet-830	26	14	poorly	poorly	ADV
admet-830	26	15	water	water	NOUN
admet-830	26	16	-	-	PUNCT
admet-830	26	17	soluble	soluble	ADJ
admet-830	26	18	antipsychotic	antipsychotic	ADJ
admet-830	26	19	drugs	drug	NOUN
admet-830	26	20	which	which	PRON
admet-830	26	21	are	be	AUX
admet-830	26	22	stipulated	stipulate	VERB
admet-830	26	23	to	to	PART
admet-830	26	24	benefit	benefit	VERB
admet-830	26	25	from	from	ADP
admet-830	26	26	reformulation	reformulation	NOUN
admet-830	26	27	within	within	ADP
admet-830	26	28	lbfs	lbfs	NOUN
admet-830	26	29	.	.	PUNCT
admet-830	27	1	lur	lur	PROPN
admet-830	27	2	and	and	CCONJ
admet-830	27	3	ris	ris	PROPN
admet-830	27	4	are	be	AUX
admet-830	27	5	weak	weak	ADJ
admet-830	27	6	monoprotic	monoprotic	ADJ
admet-830	27	7	and	and	CCONJ
admet-830	27	8	diprotic	diprotic	ADJ
admet-830	27	9	basic	basic	ADJ
admet-830	27	10	compounds	compound	NOUN
admet-830	27	11	,	,	PUNCT
admet-830	27	12	respectively	respectively	ADV
admet-830	27	13	,	,	PUNCT
admet-830	27	14	with	with	ADP
admet-830	27	15	ph	ph	ADJ
admet-830	27	16	dependent	dependent	ADJ
admet-830	27	17	solubility	solubility	NOUN
admet-830	27	18	.	.	PUNCT
admet-830	28	1	the	the	DET
admet-830	28	2	pka	pka	PROPN
admet-830	28	3	of	of	ADP
admet-830	28	4	lur	lur	PROPN
admet-830	28	5	is	be	AUX
admet-830	28	6	7.6	7.6	NUM
admet-830	28	7	,	,	PUNCT
admet-830	28	8	whereas	whereas	SCONJ
admet-830	28	9	ris	ris	PROPN
admet-830	28	10	has	have	VERB
admet-830	28	11	two	two	NUM
admet-830	28	12	pka	pka	PROPN
admet-830	28	13	values	value	NOUN
admet-830	28	14	of	of	ADP
admet-830	28	15	3.1	3.1	NUM
admet-830	28	16	and	and	CCONJ
admet-830	28	17	8.2	8.2	NUM
admet-830	28	18	[	[	SYM
admet-830	28	19	20	20	NUM
admet-830	28	20	,	,	PUNCT
admet-830	28	21	21	21	NUM
admet-830	28	22	]	]	PUNCT
admet-830	28	23	.	.	PUNCT
admet-830	29	1	therefore	therefore	ADV
admet-830	29	2	,	,	PUNCT
admet-830	29	3	at	at	ADP
admet-830	29	4	neutral	neutral	ADJ
admet-830	29	5	ph	ph	NOUN
admet-830	29	6	,	,	PUNCT
admet-830	29	7	simulating	simulate	VERB
admet-830	29	8	the	the	DET
admet-830	29	9	environment	environment	NOUN
admet-830	29	10	within	within	ADP
admet-830	29	11	the	the	DET
admet-830	29	12	small	small	ADJ
admet-830	29	13	intestine	intestine	NOUN
admet-830	29	14	,	,	PUNCT
admet-830	29	15	lur	lur	PROPN
admet-830	29	16	is	be	AUX
admet-830	29	17	approximately	approximately	ADV
admet-830	29	18	40	40	NUM
admet-830	29	19	%	%	NOUN
admet-830	29	20	positively	positively	ADV
admet-830	29	21	ionised	ionise	VERB
admet-830	29	22	,	,	PUNCT
admet-830	29	23	whereas	whereas	SCONJ
admet-830	29	24	ris	ris	PROPN
admet-830	29	25	is	be	AUX
admet-830	29	26	approximately	approximately	ADV
admet-830	29	27	80	80	NUM
admet-830	29	28	%	%	NOUN
admet-830	29	29	positively	positively	ADV
admet-830	29	30	ionised	ionise	VERB
admet-830	29	31	.	.	PUNCT
admet-830	30	1	subsequently	subsequently	ADV
admet-830	30	2	,	,	PUNCT
admet-830	30	3	only	only	ADV
admet-830	30	4	9	9	NUM
admet-830	30	5	-	-	SYM
admet-830	30	6	19	19	NUM
admet-830	30	7	%	%	NOUN
admet-830	30	8	of	of	ADP
admet-830	30	9	the	the	DET
admet-830	30	10	administrative	administrative	ADJ
admet-830	30	11	oral	oral	PROPN
admet-830	30	12	lur	lur	PROPN
admet-830	30	13	dose	dose	PROPN
admet-830	30	14	(	(	PUNCT
admet-830	30	15	ranging	range	VERB
admet-830	30	16	between	between	ADP
admet-830	30	17	20	20	NUM
admet-830	30	18	-	-	SYM
admet-830	30	19	160	160	NUM
admet-830	30	20	mg	mg	NOUN
admet-830	30	21	daily	daily	ADV
admet-830	30	22	)	)	PUNCT
admet-830	30	23	is	be	AUX
admet-830	30	24	absorbed	absorb	VERB
admet-830	30	25	,	,	PUNCT
admet-830	30	26	when	when	SCONJ
admet-830	30	27	co	co	VERB
admet-830	30	28	-	-	VERB
admet-830	30	29	administered	administer	VERB
admet-830	30	30	with	with	ADP
admet-830	30	31	a	a	DET
admet-830	30	32	meal	meal	NOUN
admet-830	30	33	[	[	X
admet-830	30	34	22	22	NUM
admet-830	30	35	,	,	PUNCT
admet-830	30	36	23	23	NUM
admet-830	30	37	]	]	PUNCT
admet-830	30	38	.	.	PUNCT
admet-830	31	1	in	in	ADP
admet-830	31	2	comparison	comparison	NOUN
admet-830	31	3	,	,	PUNCT
admet-830	31	4	a	a	DET
admet-830	31	5	daily	daily	ADJ
admet-830	31	6	oral	oral	ADJ
admet-830	31	7	ris	ris	PROPN
admet-830	31	8	dose	dose	NOUN
admet-830	31	9	of	of	ADP
admet-830	31	10	2	2	NUM
admet-830	31	11	-	-	SYM
admet-830	31	12	16	16	NUM
admet-830	31	13	mg	mg	NOUN
admet-830	31	14	has	have	VERB
admet-830	31	15	an	an	DET
admet-830	31	16	oral	oral	ADJ
admet-830	31	17	bioavailability	bioavailability	NOUN
admet-830	31	18	of	of	ADP
admet-830	31	19	approximately	approximately	ADV
admet-830	31	20	70	70	NUM
admet-830	31	21	%	%	NOUN
admet-830	31	22	,	,	PUNCT
admet-830	31	23	with	with	ADP
admet-830	31	24	erratic	erratic	ADJ
admet-830	31	25	and	and	CCONJ
admet-830	31	26	variable	variable	ADJ
admet-830	31	27	absorption	absorption	NOUN
admet-830	31	28	of	of	ADP
admet-830	31	29	up	up	ADP
admet-830	31	30	to	to	PART
admet-830	31	31	25	25	NUM
admet-830	31	32	%	%	NOUN
admet-830	31	33	between	between	ADP
admet-830	31	34	patients	patient	NOUN
admet-830	31	35	[	[	X
admet-830	31	36	24	24	NUM
admet-830	31	37	]	]	PUNCT
admet-830	31	38	.	.	PUNCT
admet-830	32	1	thus	thus	ADV
admet-830	32	2	,	,	PUNCT
admet-830	32	3	the	the	DET
admet-830	32	4	reliance	reliance	NOUN
admet-830	32	5	of	of	ADP
admet-830	32	6	patient	patient	ADJ
admet-830	32	7	compliance	compliance	NOUN
admet-830	32	8	for	for	ADP
admet-830	32	9	co	co	VERB
admet-830	32	10	-	-	ADJ
admet-830	32	11	administering	administering	ADJ
admet-830	32	12	medication	medication	NOUN
admet-830	32	13	with	with	ADP
admet-830	32	14	food	food	NOUN
admet-830	32	15	,	,	PUNCT
admet-830	32	16	along	along	ADP
admet-830	32	17	with	with	ADP
admet-830	32	18	the	the	DET
admet-830	32	19	unpredictable	unpredictable	ADJ
admet-830	32	20	bioavailability	bioavailability	NOUN
admet-830	32	21	,	,	PUNCT
admet-830	32	22	is	be	AUX
admet-830	32	23	highly	highly	ADV
admet-830	32	24	problematic	problematic	ADJ
admet-830	32	25	when	when	SCONJ
admet-830	32	26	dosing	dose	VERB
admet-830	32	27	anti	anti	NOUN
admet-830	32	28	-	-	NOUN
admet-830	32	29	psychotics	psychotic	NOUN
admet-830	32	30	,	,	PUNCT
admet-830	32	31	which	which	PRON
admet-830	32	32	highlights	highlight	VERB
admet-830	32	33	the	the	DET
admet-830	32	34	critical	critical	ADJ
admet-830	32	35	need	need	NOUN
admet-830	32	36	for	for	ADP
admet-830	32	37	reformulation	reformulation	NOUN
admet-830	32	38	of	of	ADP
admet-830	32	39	lur	lur	PROPN
admet-830	32	40	and	and	CCONJ
admet-830	32	41	ris	ris	X
admet-830	32	42	in	in	ADP
admet-830	32	43	delivery	delivery	NOUN
admet-830	32	44	systems	system	NOUN
admet-830	32	45	that	that	PRON
admet-830	32	46	enhance	enhance	VERB
admet-830	32	47	absorption	absorption	NOUN
admet-830	32	48	while	while	SCONJ
admet-830	32	49	reducing	reduce	VERB
admet-830	32	50	variability	variability	NOUN
admet-830	32	51	.	.	PUNCT
admet-830	33	1	in	in	ADP
admet-830	33	2	this	this	DET
admet-830	33	3	study	study	NOUN
admet-830	33	4	,	,	PUNCT
admet-830	33	5	lur	lur	PROPN
admet-830	33	6	and	and	CCONJ
admet-830	33	7	ris	ris	PROPN
admet-830	33	8	will	will	AUX
admet-830	33	9	be	be	AUX
admet-830	33	10	hosted	host	VERB
admet-830	33	11	within	within	ADP
admet-830	33	12	the	the	DET
admet-830	33	13	lipid	lipid	NOUN
admet-830	33	14	component	component	NOUN
admet-830	33	15	of	of	ADP
admet-830	33	16	slh	slh	ADJ
admet-830	33	17	microparticles	microparticle	NOUN
admet-830	33	18	in	in	ADP
admet-830	33	19	an	an	DET
admet-830	33	20	attempt	attempt	NOUN
admet-830	33	21	to	to	PART
admet-830	33	22	improve	improve	VERB
admet-830	33	23	their	their	PRON
admet-830	33	24	solubilisation	solubilisation	NOUN
admet-830	33	25	in	in	ADP
admet-830	33	26	simulated	simulated	ADJ
admet-830	33	27	intestinal	intestinal	ADJ
admet-830	33	28	conditions	condition	NOUN
admet-830	33	29	.	.	PUNCT
admet-830	34	1	the	the	DET
admet-830	34	2	solubilising	solubilising	ADJ
admet-830	34	3	effects	effect	NOUN
admet-830	34	4	of	of	ADP
admet-830	34	5	slh	slh	ADJ
admet-830	34	6	formulations	formulation	NOUN
admet-830	34	7	will	will	AUX
admet-830	34	8	be	be	AUX
admet-830	34	9	compared	compare	VERB
admet-830	34	10	to	to	ADP
admet-830	34	11	a	a	DET
admet-830	34	12	conventional	conventional	ADJ
admet-830	34	13	drug	drug	NOUN
admet-830	34	14	in	in	ADP
admet-830	34	15	lipid	lipid	NOUN
admet-830	34	16	emulsion	emulsion	NOUN
admet-830	34	17	,	,	PUNCT
admet-830	34	18	and	and	CCONJ
admet-830	34	19	unformulated	unformulate	VERB
admet-830	34	20	pure	pure	ADJ
admet-830	34	21	drug	drug	NOUN
admet-830	34	22	.	.	PUNCT
admet-830	35	1	in	in	ADP
admet-830	35	2	doing	do	VERB
admet-830	35	3	so	so	ADV
admet-830	35	4	,	,	PUNCT
admet-830	35	5	the	the	DET
admet-830	35	6	impact	impact	NOUN
admet-830	35	7	of	of	ADP
admet-830	35	8	(	(	PUNCT
admet-830	35	9	i	i	NOUN
admet-830	35	10	)	)	PUNCT
admet-830	35	11	drug	drug	NOUN
admet-830	35	12	ionisation	ionisation	NOUN
admet-830	35	13	and	and	CCONJ
admet-830	35	14	(	(	PUNCT
admet-830	35	15	ii	ii	NOUN
admet-830	35	16	)	)	PUNCT
admet-830	35	17	formulation	formulation	NOUN
admet-830	35	18	physicochemical	physicochemical	ADJ
admet-830	35	19	properties	property	NOUN
admet-830	35	20	,	,	PUNCT
admet-830	35	21	on	on	ADV
admet-830	35	22	in	in	ADP
admet-830	35	23	vitro	vitro	X
admet-830	35	24	dissolution	dissolution	NOUN
admet-830	35	25	and	and	CCONJ
admet-830	35	26	solubilisation	solubilisation	NOUN
admet-830	35	27	under	under	ADP
admet-830	35	28	non	non	ADJ
admet-830	35	29	-	-	ADJ
admet-830	35	30	digesting	digest	VERB
admet-830	35	31	and	and	CCONJ
admet-830	35	32	digesting	digest	VERB
admet-830	35	33	conditions	condition	NOUN
admet-830	35	34	will	will	AUX
admet-830	35	35	be	be	AUX
admet-830	35	36	critically	critically	ADV
admet-830	35	37	evaluated	evaluate	VERB
admet-830	35	38	.	.	PUNCT
admet-830	36	1	it	it	PRON
admet-830	36	2	was	be	AUX
admet-830	36	3	hypothesised	hypothesise	VERB
admet-830	36	4	that	that	SCONJ
admet-830	36	5	fabrication	fabrication	NOUN
admet-830	36	6	of	of	ADP
admet-830	36	7	ris	ris	PROPN
admet-830	36	8	and	and	CCONJ
admet-830	36	9	lur	lur	PROPN
admet-830	36	10	within	within	ADP
admet-830	36	11	lbfs	lbfs	NOUN
admet-830	36	12	,	,	PUNCT
admet-830	36	13	specifically	specifically	ADV
admet-830	36	14	slh	slh	ADJ
admet-830	36	15	microparticles	microparticle	NOUN
admet-830	36	16	,	,	PUNCT
admet-830	36	17	will	will	AUX
admet-830	36	18	maximise	maximise	VERB
admet-830	36	19	drug	drug	NOUN
admet-830	36	20	solubilisation	solubilisation	NOUN
admet-830	36	21	,	,	PUNCT
admet-830	36	22	under	under	ADP
admet-830	36	23	simulated	simulated	ADJ
admet-830	36	24	intestinal	intestinal	ADJ
admet-830	36	25	conditions	condition	NOUN
admet-830	36	26	in	in	ADP
admet-830	36	27	the	the	DET
admet-830	36	28	fasted	fasted	ADJ
admet-830	36	29	state	state	NOUN
admet-830	36	30	,	,	PUNCT
admet-830	36	31	due	due	ADP
admet-830	36	32	to	to	ADP
admet-830	36	33	the	the	DET
admet-830	36	34	ability	ability	NOUN
admet-830	36	35	for	for	ADP
admet-830	36	36	lipid	lipid	ADJ
admet-830	36	37	species	specie	NOUN
admet-830	36	38	to	to	PART
admet-830	36	39	maintain	maintain	VERB
admet-830	36	40	the	the	DET
admet-830	36	41	drug	drug	NOUN
admet-830	36	42	in	in	ADP
admet-830	36	43	a	a	DET
admet-830	36	44	molecular	molecular	ADJ
admet-830	36	45	form	form	NOUN
admet-830	36	46	.	.	PUNCT
admet-830	37	1	by	by	ADP
admet-830	37	2	investigating	investigate	VERB
admet-830	37	3	the	the	DET
admet-830	37	4	impact	impact	NOUN
admet-830	37	5	of	of	ADP
admet-830	37	6	drug	drug	NOUN
admet-830	37	7	ionisation	ionisation	NOUN
admet-830	37	8	on	on	ADP
admet-830	37	9	solubilisation	solubilisation	NOUN
admet-830	37	10	behaviour	behaviour	NOUN
admet-830	37	11	,	,	PUNCT
admet-830	37	12	new	new	ADJ
admet-830	37	13	insights	insight	NOUN
admet-830	37	14	will	will	AUX
admet-830	37	15	be	be	AUX
admet-830	37	16	derived	derive	VERB
admet-830	37	17	regarding	regard	VERB
admet-830	37	18	the	the	DET
admet-830	37	19	key	key	ADJ
admet-830	37	20	physicochemical	physicochemical	ADJ
admet-830	37	21	properties	property	NOUN
admet-830	37	22	of	of	ADP
admet-830	37	23	solidstate	solidstate	PROPN
admet-830	37	24	lbfs	lbfs	PROPN
admet-830	37	25	required	require	VERB
admet-830	37	26	for	for	ADP
admet-830	37	27	improving	improve	VERB
admet-830	37	28	oral	oral	ADJ
admet-830	37	29	delivery	delivery	NOUN
admet-830	37	30	performance	performance	NOUN
admet-830	37	31	.	.	PUNCT
admet-830	38	1	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	38	2	admet	admet	PROPN
admet-830	38	3	&	&	CCONJ
admet-830	38	4	dmpk	dmpk	PROPN
admet-830	38	5	8(4	8(4	NOUN
admet-830	38	6	)	)	PUNCT
admet-830	38	7	(	(	PUNCT
admet-830	38	8	2020	2020	NUM
admet-830	38	9	)	)	PUNCT
admet-830	38	10	437	437	NUM
admet-830	38	11	-	-	SYM
admet-830	38	12	451	451	NUM
admet-830	38	13	drug	drug	NOUN
admet-830	38	14	ionisation	ionisation	NOUN
admet-830	38	15	and	and	CCONJ
admet-830	38	16	lipid	lipid	NOUN
admet-830	38	17	-	-	PUNCT
admet-830	38	18	based	base	VERB
admet-830	38	19	formulations	formulation	NOUN
admet-830	38	20	doi	doi	NOUN
admet-830	38	21	:	:	PUNCT
admet-830	38	22	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	38	23	439	439	NUM
admet-830	38	24	experimental	experimental	ADJ
admet-830	38	25	materials	material	NOUN
admet-830	38	26	risperidone	risperidone	NOUN
admet-830	38	27	(	(	PUNCT
admet-830	38	28	ris	ris	PROPN
admet-830	38	29	)	)	PUNCT
admet-830	38	30	,	,	PUNCT
admet-830	38	31	lurasidone	lurasidone	NOUN
admet-830	38	32	(	(	PUNCT
admet-830	38	33	lur	lur	PROPN
admet-830	38	34	)	)	PUNCT
admet-830	38	35	and	and	CCONJ
admet-830	38	36	ziprasidone	ziprasidone	NOUN
admet-830	38	37	powders	powder	NOUN
admet-830	38	38	were	be	AUX
admet-830	38	39	purchased	purchase	VERB
admet-830	38	40	from	from	ADP
admet-830	38	41	hangzhou	hangzhou	PROPN
admet-830	38	42	dayangchem	dayangchem	PROPN
admet-830	38	43	co.	co.	PROPN
admet-830	38	44	ltd	ltd	PROPN
admet-830	38	45	(	(	PUNCT
admet-830	38	46	hangzhou	hangzhou	PROPN
admet-830	38	47	,	,	PUNCT
admet-830	38	48	china	china	PROPN
admet-830	38	49	)	)	PUNCT
admet-830	38	50	.	.	PUNCT
admet-830	39	1	capmul	capmul	PROPN
admet-830	39	2	®	®	PROPN
admet-830	39	3	mcm	mcm	PROPN
admet-830	39	4	(	(	PUNCT
admet-830	39	5	glyceryl	glyceryl	NOUN
admet-830	39	6	monoand	monoand	NOUN
admet-830	39	7	dicaprylate	dicaprylate	NOUN
admet-830	39	8	)	)	PUNCT
admet-830	39	9	was	be	AUX
admet-830	39	10	a	a	DET
admet-830	39	11	gift	gift	NOUN
admet-830	39	12	from	from	ADP
admet-830	39	13	abitec	abitec	ADJ
admet-830	39	14	corporation	corporation	NOUN
admet-830	39	15	(	(	PUNCT
admet-830	39	16	wisconsin	wisconsin	PROPN
admet-830	39	17	,	,	PUNCT
admet-830	39	18	usa	usa	PROPN
admet-830	39	19	)	)	PUNCT
admet-830	39	20	.	.	PUNCT
admet-830	40	1	hydrophilic	hydrophilic	PROPN
admet-830	40	2	fumed	fume	VERB
admet-830	40	3	silica	silica	NOUN
admet-830	40	4	nanoparticles	nanoparticle	NOUN
admet-830	40	5	(	(	PUNCT
admet-830	40	6	aerosil	aerosil	NOUN
admet-830	40	7	®	®	NOUN
admet-830	40	8	300	300	NUM
admet-830	40	9	)	)	PUNCT
admet-830	40	10	were	be	AUX
admet-830	40	11	supplied	supply	VERB
admet-830	40	12	by	by	ADP
admet-830	40	13	evonik	evonik	X
admet-830	40	14	degussa	degussa	PROPN
admet-830	40	15	(	(	PUNCT
admet-830	40	16	essen	essen	PROPN
admet-830	40	17	,	,	PUNCT
admet-830	40	18	germany	germany	PROPN
admet-830	40	19	)	)	PUNCT
admet-830	40	20	.	.	PUNCT
admet-830	41	1	soybean	soybean	NOUN
admet-830	41	2	lecithin	lecithin	NOUN
admet-830	41	3	was	be	AUX
admet-830	41	4	purchased	purchase	VERB
admet-830	41	5	from	from	ADP
admet-830	41	6	bdh	bdh	PROPN
admet-830	41	7	merck	merck	PROPN
admet-830	41	8	(	(	PUNCT
admet-830	41	9	sydney	sydney	PROPN
admet-830	41	10	,	,	PUNCT
admet-830	41	11	australia	australia	PROPN
admet-830	41	12	)	)	PUNCT
admet-830	41	13	.	.	PUNCT
admet-830	42	1	sodium	sodium	NOUN
admet-830	42	2	dihydrogen	dihydrogen	NOUN
admet-830	42	3	phosphate	phosphate	NOUN
admet-830	42	4	(	(	PUNCT
admet-830	42	5	nah2po4	nah2po4	PROPN
admet-830	42	6	)	)	PUNCT
admet-830	42	7	,	,	PUNCT
admet-830	42	8	orthophosphoric	orthophosphoric	ADJ
admet-830	42	9	acid	acid	NOUN
admet-830	42	10	,	,	PUNCT
admet-830	42	11	potassium	potassium	NOUN
admet-830	42	12	dihydrogen	dihydrogen	NOUN
admet-830	42	13	phosphate	phosphate	NOUN
admet-830	42	14	(	(	PUNCT
admet-830	42	15	kh2po4	kh2po4	NOUN
admet-830	42	16	)	)	PUNCT
admet-830	42	17	,	,	PUNCT
admet-830	42	18	sodium	sodium	NOUN
admet-830	42	19	hydroxide	hydroxide	NOUN
admet-830	42	20	pellets	pellet	NOUN
admet-830	42	21	(	(	PUNCT
admet-830	42	22	naoh	naoh	NOUN
admet-830	42	23	)	)	PUNCT
admet-830	42	24	,	,	PUNCT
admet-830	42	25	tween	tween	NOUN
admet-830	42	26	80	80	NUM
admet-830	42	27	,	,	PUNCT
admet-830	42	28	and	and	CCONJ
admet-830	42	29	trizma	trizma	ADP
admet-830	42	30	®	®	NOUN
admet-830	42	31	maleate	maleate	NOUN
admet-830	42	32	,	,	PUNCT
admet-830	42	33	sodium	sodium	NOUN
admet-830	42	34	chloride	chloride	NOUN
admet-830	42	35	(	(	PUNCT
admet-830	42	36	nacl	nacl	NOUN
admet-830	42	37	)	)	PUNCT
admet-830	42	38	,	,	PUNCT
admet-830	42	39	calcium	calcium	NOUN
admet-830	42	40	chloride	chloride	NOUN
admet-830	42	41	dehydrate	dehydrate	NOUN
admet-830	42	42	(	(	PUNCT
admet-830	42	43	cacl2.2h2o	cacl2.2h2o	NOUN
admet-830	42	44	)	)	PUNCT
admet-830	42	45	,	,	PUNCT
admet-830	42	46	egg	egg	NOUN
admet-830	42	47	lecithin	lecithin	NOUN
admet-830	42	48	(	(	PUNCT
admet-830	42	49	consisting	consist	VERB
admet-830	42	50	of	of	ADP
admet-830	42	51	60	60	NUM
admet-830	42	52	%	%	NOUN
admet-830	42	53	phosphatidylcholine	phosphatidylcholine	NOUN
admet-830	42	54	from	from	ADP
admet-830	42	55	dried	dry	VERB
admet-830	42	56	egg	egg	NOUN
admet-830	42	57	yolk	yolk	NOUN
admet-830	42	58	)	)	PUNCT
admet-830	42	59	,	,	PUNCT
admet-830	42	60	sodium	sodium	NOUN
admet-830	42	61	taurodeoxycholate	taurodeoxycholate	NOUN
admet-830	42	62	(	(	PUNCT
admet-830	42	63	natdc	natdc	NOUN
admet-830	42	64	)	)	PUNCT
admet-830	42	65	,	,	PUNCT
admet-830	42	66	4	4	NUM
admet-830	42	67	-	-	PUNCT
admet-830	42	68	bromophenylboronic	bromophenylboronic	ADJ
admet-830	42	69	acid	acid	NOUN
admet-830	42	70	(	(	PUNCT
admet-830	42	71	4	4	NUM
admet-830	42	72	-	-	PUNCT
admet-830	42	73	bba	bba	NOUN
admet-830	42	74	)	)	PUNCT
admet-830	42	75	and	and	CCONJ
admet-830	42	76	myristic	myristic	ADJ
admet-830	42	77	acid	acid	NOUN
admet-830	42	78	were	be	AUX
admet-830	42	79	purchased	purchase	VERB
admet-830	42	80	from	from	ADP
admet-830	42	81	sigma	sigma	PROPN
admet-830	42	82	aldrich	aldrich	PROPN
admet-830	42	83	(	(	PUNCT
admet-830	42	84	sydney	sydney	PROPN
admet-830	42	85	,	,	PUNCT
admet-830	42	86	australia	australia	PROPN
admet-830	42	87	)	)	PUNCT
admet-830	42	88	and	and	CCONJ
admet-830	42	89	porcine	porcine	VERB
admet-830	42	90	pancreatin	pancreatin	ADJ
admet-830	42	91	extracts	extract	NOUN
admet-830	42	92	from	from	ADP
admet-830	42	93	mp	mp	NOUN
admet-830	42	94	biomedicals	biomedical	NOUN
admet-830	42	95	(	(	PUNCT
admet-830	42	96	sydney	sydney	PROPN
admet-830	42	97	,	,	PUNCT
admet-830	42	98	australia	australia	PROPN
admet-830	42	99	)	)	PUNCT
admet-830	42	100	.	.	PUNCT
admet-830	43	1	high	high	ADJ
admet-830	43	2	purity	purity	NOUN
admet-830	43	3	(	(	PUNCT
admet-830	43	4	milli	milli	NOUN
admet-830	43	5	-	-	PUNCT
admet-830	43	6	q	q	NOUN
admet-830	43	7	)	)	PUNCT
admet-830	43	8	water	water	NOUN
admet-830	43	9	and	and	CCONJ
admet-830	43	10	hplc	hplc	NOUN
admet-830	43	11	grade	grade	NOUN
admet-830	43	12	solvents	solvent	NOUN
admet-830	43	13	were	be	AUX
admet-830	43	14	used	use	VERB
admet-830	43	15	during	during	ADP
admet-830	43	16	the	the	DET
admet-830	43	17	study	study	NOUN
admet-830	43	18	.	.	PUNCT
admet-830	44	1	high	high	ADJ
admet-830	44	2	-	-	PUNCT
admet-830	44	3	performance	performance	NOUN
admet-830	44	4	liquid	liquid	ADJ
admet-830	44	5	chromatography	chromatography	NOUN
admet-830	44	6	(	(	PUNCT
admet-830	44	7	hplc	hplc	PROPN
admet-830	44	8	)	)	PUNCT
admet-830	44	9	the	the	DET
admet-830	44	10	concentrations	concentration	NOUN
admet-830	44	11	of	of	ADP
admet-830	44	12	ris	ris	PROPN
admet-830	44	13	and	and	CCONJ
admet-830	44	14	lur	lur	PROPN
admet-830	44	15	were	be	AUX
admet-830	44	16	quantified	quantify	VERB
admet-830	44	17	using	use	VERB
admet-830	44	18	high	high	ADJ
admet-830	44	19	performance	performance	NOUN
admet-830	44	20	liquid	liquid	NOUN
admet-830	44	21	chromatography	chromatography	NOUN
admet-830	44	22	(	(	PUNCT
admet-830	44	23	hplc	hplc	NOUN
admet-830	44	24	)	)	PUNCT
admet-830	44	25	analysis	analysis	NOUN
admet-830	44	26	on	on	ADP
admet-830	44	27	a	a	DET
admet-830	44	28	shimadzu	shimadzu	ADJ
admet-830	44	29	prominence	prominence	NOUN
admet-830	44	30	ultra	ultra	ADJ
admet-830	44	31	-	-	ADJ
admet-830	44	32	fast	fast	ADJ
admet-830	44	33	liquid	liquid	ADJ
admet-830	44	34	chromatograph	chromatograph	NOUN
admet-830	44	35	(	(	PUNCT
admet-830	44	36	uflc	uflc	PROPN
admet-830	44	37	xr	xr	PROPN
admet-830	44	38	)	)	PUNCT
admet-830	44	39	system	system	NOUN
admet-830	44	40	,	,	PUNCT
admet-830	44	41	equipped	equip	VERB
admet-830	44	42	with	with	ADP
admet-830	44	43	a	a	DET
admet-830	44	44	phenomenex	phenomenex	ADV
admet-830	44	45	luna	luna	PROPN
admet-830	44	46	5	5	NUM
admet-830	44	47	µm	µm	ADP
admet-830	44	48	c18	c18	NOUN
admet-830	44	49	100	100	NUM
admet-830	44	50	å	å	PROPN
admet-830	44	51	(	(	PUNCT
admet-830	44	52	250	250	NUM
admet-830	44	53	mm	mm	NOUN
admet-830	44	54	×	×	NOUN
admet-830	44	55	4.6	4.6	NUM
admet-830	44	56	mm	mm	NOUN
admet-830	44	57	)	)	PUNCT
admet-830	44	58	column	column	NOUN
admet-830	44	59	,	,	PUNCT
admet-830	44	60	maintained	maintain	VERB
admet-830	44	61	at	at	ADP
admet-830	44	62	40	40	NUM
admet-830	44	63	°	°	NOUN
admet-830	44	64	c	c	NOUN
admet-830	44	65	.	.	PUNCT
admet-830	45	1	an	an	DET
admet-830	45	2	isocratic	isocratic	ADJ
admet-830	45	3	elution	elution	NOUN
admet-830	45	4	method	method	NOUN
admet-830	45	5	was	be	AUX
admet-830	45	6	employed	employ	VERB
admet-830	45	7	at	at	ADP
admet-830	45	8	a	a	DET
admet-830	45	9	flow	flow	NOUN
admet-830	45	10	rate	rate	NOUN
admet-830	45	11	of	of	ADP
admet-830	45	12	1	1	NUM
admet-830	45	13	ml	ml	NOUN
admet-830	45	14	/	/	SYM
admet-830	45	15	min	min	NOUN
admet-830	45	16	,	,	PUNCT
admet-830	45	17	using	use	VERB
admet-830	45	18	a	a	DET
admet-830	45	19	mobile	mobile	ADJ
admet-830	45	20	phase	phase	NOUN
admet-830	45	21	comprising	comprising	NOUN
admet-830	45	22	of	of	ADP
admet-830	45	23	0.05	0.05	NUM
admet-830	45	24	m	m	NOUN
admet-830	45	25	nah2po4	nah2po4	NOUN
admet-830	45	26	buffer	buffer	NOUN
admet-830	45	27	(	(	PUNCT
admet-830	45	28	adjusted	adjust	VERB
admet-830	45	29	to	to	ADP
admet-830	45	30	ph	ph	PROPN
admet-830	45	31	3	3	NUM
admet-830	45	32	using	use	VERB
admet-830	45	33	orthophosphoric	orthophosphoric	ADJ
admet-830	45	34	acid	acid	NOUN
admet-830	45	35	)	)	PUNCT
admet-830	45	36	and	and	CCONJ
admet-830	45	37	methanol	methanol	NOUN
admet-830	45	38	(	(	PUNCT
admet-830	45	39	40:60	40:60	NUM
admet-830	45	40	and	and	CCONJ
admet-830	45	41	25:75	25:75	NUM
admet-830	45	42	v	v	NOUN
admet-830	45	43	/	/	SYM
admet-830	45	44	v	v	NOUN
admet-830	45	45	for	for	ADP
admet-830	45	46	ris	ris	PROPN
admet-830	45	47	and	and	CCONJ
admet-830	45	48	lur	lur	PROPN
admet-830	45	49	,	,	PUNCT
admet-830	45	50	respectively	respectively	ADV
admet-830	45	51	)	)	PUNCT
admet-830	45	52	.	.	PUNCT
admet-830	46	1	ris	ris	PROPN
admet-830	46	2	was	be	AUX
admet-830	46	3	detected	detect	VERB
admet-830	46	4	at	at	ADP
admet-830	46	5	a	a	DET
admet-830	46	6	wavelength	wavelength	NOUN
admet-830	46	7	of	of	ADP
admet-830	46	8	280	280	NUM
admet-830	46	9	nm	nm	NOUN
admet-830	46	10	at	at	ADP
admet-830	46	11	a	a	DET
admet-830	46	12	retention	retention	NOUN
admet-830	46	13	time	time	NOUN
admet-830	46	14	of	of	ADP
admet-830	46	15	3.8	3.8	NUM
admet-830	46	16	min	min	NOUN
admet-830	46	17	,	,	PUNCT
admet-830	46	18	whereas	whereas	SCONJ
admet-830	46	19	lur	lur	PROPN
admet-830	46	20	was	be	AUX
admet-830	46	21	detected	detect	VERB
admet-830	46	22	at	at	ADP
admet-830	46	23	231	231	NUM
admet-830	46	24	nm	nm	NOUN
admet-830	46	25	with	with	ADP
admet-830	46	26	an	an	DET
admet-830	46	27	average	average	ADJ
admet-830	46	28	retention	retention	NOUN
admet-830	46	29	time	time	NOUN
admet-830	46	30	of	of	ADP
admet-830	46	31	5.8	5.8	NUM
admet-830	46	32	min	min	NOUN
admet-830	46	33	.	.	PROPN
admet-830	46	34	linear	linear	PROPN
admet-830	46	35	calibration	calibration	NOUN
admet-830	46	36	curves	curve	NOUN
admet-830	46	37	were	be	AUX
admet-830	46	38	generated	generate	VERB
admet-830	46	39	for	for	ADP
admet-830	46	40	both	both	DET
admet-830	46	41	compounds	compound	NOUN
admet-830	46	42	using	use	VERB
admet-830	46	43	chromatographic	chromatographic	ADJ
admet-830	46	44	peak	peak	NOUN
admet-830	46	45	area	area	NOUN
admet-830	46	46	against	against	ADP
admet-830	46	47	standard	standard	ADJ
admet-830	46	48	concentrations	concentration	NOUN
admet-830	46	49	over	over	ADP
admet-830	46	50	a	a	DET
admet-830	46	51	range	range	NOUN
admet-830	46	52	of	of	ADP
admet-830	46	53	0.02	0.02	NUM
admet-830	46	54	-	-	SYM
admet-830	46	55	20	20	NUM
admet-830	46	56	µg	µg	NOUN
admet-830	46	57	/	/	SYM
admet-830	46	58	ml	ml	NOUN
admet-830	46	59	.	.	PUNCT
admet-830	46	60	quality	quality	NOUN
admet-830	46	61	control	control	NOUN
admet-830	46	62	standards	standard	NOUN
admet-830	46	63	were	be	AUX
admet-830	46	64	analysed	analyse	VERB
admet-830	46	65	with	with	ADP
admet-830	46	66	every	every	DET
admet-830	46	67	sample	sample	NOUN
admet-830	46	68	batch	batch	NOUN
admet-830	46	69	.	.	PUNCT
admet-830	47	1	the	the	DET
admet-830	47	2	precision	precision	NOUN
admet-830	47	3	and	and	CCONJ
admet-830	47	4	accuracy	accuracy	NOUN
admet-830	47	5	of	of	ADP
admet-830	47	6	interand	interand	NOUN
admet-830	47	7	intra	intra	ADJ
admet-830	47	8	-	-	ADJ
admet-830	47	9	day	day	ADJ
admet-830	47	10	analyses	analysis	NOUN
admet-830	47	11	were	be	AUX
admet-830	47	12	within	within	ADP
admet-830	47	13	an	an	DET
admet-830	47	14	acceptable	acceptable	ADJ
admet-830	47	15	range	range	NOUN
admet-830	47	16	of	of	ADP
admet-830	47	17	less	less	ADJ
admet-830	47	18	than	than	ADP
admet-830	47	19	10	10	NUM
admet-830	47	20	%	%	NOUN
admet-830	47	21	.	.	PUNCT
admet-830	48	1	liquid	liquid	ADJ
admet-830	48	2	chromatography	chromatography	NOUN
admet-830	48	3	-	-	PUNCT
admet-830	48	4	mass	mass	NOUN
admet-830	48	5	spectrometry	spectrometry	NOUN
admet-830	48	6	(	(	PUNCT
admet-830	48	7	lcms	lcms	PROPN
admet-830	48	8	)	)	PUNCT
admet-830	48	9	the	the	DET
admet-830	48	10	concentration	concentration	NOUN
admet-830	48	11	of	of	ADP
admet-830	48	12	lur	lur	NOUN
admet-830	48	13	for	for	ADP
admet-830	48	14	drug	drug	NOUN
admet-830	48	15	solubilisation	solubilisation	NOUN
admet-830	48	16	studies	study	NOUN
admet-830	48	17	was	be	AUX
admet-830	48	18	determined	determine	VERB
admet-830	48	19	using	use	VERB
admet-830	48	20	liquid	liquid	ADJ
admet-830	48	21	chromatographymass	chromatographymass	NOUN
admet-830	48	22	spectrometry	spectrometry	NOUN
admet-830	48	23	(	(	PUNCT
admet-830	48	24	lcms	lcms	PROPN
admet-830	48	25	)	)	PUNCT
admet-830	48	26	on	on	ADP
admet-830	48	27	a	a	DET
admet-830	48	28	shimadzu	shimadzu	ADJ
admet-830	48	29	8030	8030	NUM
admet-830	48	30	mass	mass	NOUN
admet-830	48	31	spectrometer	spectrometer	NOUN
admet-830	48	32	(	(	PUNCT
admet-830	48	33	kyoto	kyoto	PROPN
admet-830	48	34	,	,	PUNCT
admet-830	48	35	japan	japan	PROPN
admet-830	48	36	)	)	PUNCT
admet-830	48	37	.	.	PUNCT
admet-830	49	1	a	a	DET
admet-830	49	2	10	10	NUM
admet-830	49	3	µl	µl	ADP
admet-830	49	4	sample	sample	NOUN
admet-830	49	5	was	be	AUX
admet-830	49	6	injected	inject	VERB
admet-830	49	7	into	into	ADP
admet-830	49	8	a	a	DET
admet-830	49	9	phenomenex	phenomenex	ADV
admet-830	49	10	kinetex	kinetex	NOUN
admet-830	49	11	2.6	2.6	NUM
admet-830	49	12	µm	µm	ADP
admet-830	49	13	c18	c18	NOUN
admet-830	49	14	100	100	NUM
admet-830	49	15	å	å	PROPN
admet-830	49	16	(	(	PUNCT
admet-830	49	17	50	50	NUM
admet-830	49	18	mm	mm	NOUN
admet-830	49	19	×	×	NOUN
admet-830	49	20	3	3	NUM
admet-830	49	21	mm	mm	NOUN
admet-830	49	22	)	)	PUNCT
admet-830	49	23	column	column	NOUN
admet-830	49	24	,	,	PUNCT
admet-830	49	25	maintained	maintain	VERB
admet-830	49	26	at	at	ADP
admet-830	49	27	40	40	NUM
admet-830	49	28	°	°	NOUN
admet-830	49	29	c	c	NOUN
admet-830	49	30	.	.	PUNCT
admet-830	50	1	a	a	DET
admet-830	50	2	gradient	gradient	ADJ
admet-830	50	3	elution	elution	NOUN
admet-830	50	4	method	method	NOUN
admet-830	50	5	consisting	consist	VERB
admet-830	50	6	of	of	ADP
admet-830	50	7	(	(	PUNCT
admet-830	50	8	a	a	PRON
admet-830	50	9	)	)	PUNCT
admet-830	50	10	milli	milli	ADJ
admet-830	50	11	-	-	PUNCT
admet-830	50	12	q	q	NOUN
admet-830	50	13	water	water	NOUN
admet-830	50	14	+	+	CCONJ
admet-830	50	15	0.1	0.1	NUM
admet-830	50	16	%	%	NOUN
admet-830	50	17	formic	formic	NOUN
admet-830	50	18	acid	acid	NOUN
admet-830	50	19	and	and	CCONJ
admet-830	50	20	(	(	PUNCT
admet-830	50	21	b	b	NOUN
admet-830	50	22	)	)	PUNCT
admet-830	50	23	acetonitrile	acetonitrile	NOUN
admet-830	50	24	+	+	CCONJ
admet-830	50	25	0.1	0.1	NUM
admet-830	50	26	%	%	NOUN
admet-830	50	27	formic	formic	ADJ
admet-830	50	28	acid	acid	NOUN
admet-830	50	29	was	be	AUX
admet-830	50	30	employed	employ	VERB
admet-830	50	31	at	at	ADP
admet-830	50	32	a	a	DET
admet-830	50	33	flow	flow	NOUN
admet-830	50	34	rate	rate	NOUN
admet-830	50	35	of	of	ADP
admet-830	50	36	0.4	0.4	NUM
admet-830	50	37	ml	ml	NOUN
admet-830	50	38	/	/	SYM
admet-830	50	39	min	min	NOUN
admet-830	50	40	.	.	PROPN
admet-830	50	41	multiple	multiple	ADJ
admet-830	50	42	mode	mode	NOUN
admet-830	50	43	monitoring	monitoring	NOUN
admet-830	50	44	was	be	AUX
admet-830	50	45	used	use	VERB
admet-830	50	46	to	to	PART
admet-830	50	47	quantify	quantify	VERB
admet-830	50	48	the	the	DET
admet-830	50	49	internal	internal	ADJ
admet-830	50	50	standard	standard	ADJ
admet-830	50	51	ziprasidone	ziprasidone	NOUN
admet-830	50	52	precursor	precursor	NOUN
admet-830	50	53	at	at	ADP
admet-830	50	54	413.2	413.2	NUM
admet-830	50	55	m	m	NOUN
admet-830	50	56	/	/	SYM
admet-830	50	57	z	z	NOUN
admet-830	50	58	and	and	CCONJ
admet-830	50	59	product	product	NOUN
admet-830	50	60	at	at	ADP
admet-830	50	61	194.0	194.0	NUM
admet-830	50	62	m	m	NOUN
admet-830	50	63	/	/	SYM
admet-830	50	64	z.	z.	PROPN
admet-830	50	65	lur	lur	PROPN
admet-830	50	66	precursor	precursor	NOUN
admet-830	50	67	was	be	AUX
admet-830	50	68	detected	detect	VERB
admet-830	50	69	at	at	ADP
admet-830	50	70	493.2	493.2	NUM
admet-830	50	71	m	m	PROPN
admet-830	50	72	/	/	SYM
admet-830	50	73	z	z	NOUN
admet-830	50	74	and	and	CCONJ
admet-830	50	75	product	product	NOUN
admet-830	50	76	at	at	ADP
admet-830	50	77	166.1	166.1	NUM
admet-830	50	78	m	m	NOUN
admet-830	50	79	/	/	SYM
admet-830	50	80	z.	z.	PROPN
admet-830	50	81	linear	linear	PROPN
admet-830	50	82	calibration	calibration	NOUN
admet-830	50	83	curves	curve	NOUN
admet-830	50	84	were	be	AUX
admet-830	50	85	generated	generate	VERB
admet-830	50	86	over	over	ADP
admet-830	50	87	concentrations	concentration	NOUN
admet-830	50	88	ranging	range	VERB
admet-830	50	89	from	from	ADP
admet-830	50	90	0.2	0.2	NUM
admet-830	50	91	-	-	SYM
admet-830	50	92	1	1	NUM
admet-830	50	93	µg	µg	NOUN
admet-830	50	94	/	/	SYM
admet-830	50	95	ml	ml	VERB
admet-830	50	96	by	by	ADP
admet-830	50	97	plotting	plot	VERB
admet-830	50	98	peak	peak	NOUN
admet-830	50	99	area	area	NOUN
admet-830	50	100	ratio	ratio	NOUN
admet-830	50	101	of	of	ADP
admet-830	50	102	analyte	analyte	NOUN
admet-830	50	103	:	:	PUNCT
admet-830	50	104	internal	internal	ADJ
admet-830	50	105	standard	standard	NOUN
admet-830	50	106	against	against	ADP
admet-830	50	107	known	known	ADJ
admet-830	50	108	concentrations	concentration	NOUN
admet-830	50	109	.	.	PUNCT
admet-830	51	1	preparation	preparation	NOUN
admet-830	51	2	of	of	ADP
admet-830	51	3	drug	drug	NOUN
admet-830	51	4	loaded	load	VERB
admet-830	51	5	lipid	lipid	NOUN
admet-830	51	6	emulsions	emulsion	NOUN
admet-830	51	7	the	the	DET
admet-830	51	8	equilibrium	equilibrium	NOUN
admet-830	51	9	solubilities	solubility	NOUN
admet-830	51	10	of	of	ADP
admet-830	51	11	lur	lur	PROPN
admet-830	51	12	and	and	CCONJ
admet-830	51	13	ris	ris	PROPN
admet-830	51	14	in	in	ADP
admet-830	51	15	miglyol	miglyol	NOUN
admet-830	51	16	®	®	NOUN
admet-830	51	17	812	812	NUM
admet-830	51	18	,	,	PUNCT
admet-830	51	19	capmul	capmul	PROPN
admet-830	51	20	®	®	PROPN
admet-830	51	21	mcm	mcm	PROPN
admet-830	51	22	and	and	CCONJ
admet-830	51	23	soybean	soybean	NOUN
admet-830	51	24	oil	oil	NOUN
admet-830	51	25	were	be	AUX
admet-830	51	26	determined	determine	VERB
admet-830	51	27	by	by	ADP
admet-830	51	28	adding	add	VERB
admet-830	51	29	excess	excess	ADJ
admet-830	51	30	drug	drug	NOUN
admet-830	51	31	to	to	ADP
admet-830	51	32	a	a	DET
admet-830	51	33	known	know	VERB
admet-830	51	34	quantity	quantity	NOUN
admet-830	51	35	of	of	ADP
admet-830	51	36	lipid	lipid	NOUN
admet-830	51	37	.	.	PUNCT
admet-830	52	1	the	the	DET
admet-830	52	2	drug	drug	NOUN
admet-830	52	3	-	-	PUNCT
admet-830	52	4	lipid	lipid	NOUN
admet-830	52	5	suspensions	suspension	NOUN
admet-830	52	6	were	be	AUX
admet-830	52	7	sonicated	sonicate	VERB
admet-830	52	8	for	for	ADP
admet-830	52	9	10	10	NUM
admet-830	52	10	min	min	NOUN
admet-830	52	11	to	to	PART
admet-830	52	12	facilitate	facilitate	VERB
admet-830	52	13	dissolution	dissolution	NOUN
admet-830	52	14	,	,	PUNCT
admet-830	52	15	prior	prior	ADV
admet-830	52	16	to	to	ADP
admet-830	52	17	rotating	rotate	VERB
admet-830	52	18	for	for	ADP
admet-830	52	19	72	72	NUM
admet-830	52	20	h	h	NOUN
admet-830	52	21	at	at	ADP
admet-830	52	22	room	room	NOUN
admet-830	52	23	temperature	temperature	NOUN
admet-830	52	24	,	,	PUNCT
admet-830	52	25	protected	protect	VERB
admet-830	52	26	from	from	ADP
admet-830	52	27	light	light	NOUN
admet-830	52	28	.	.	PUNCT
admet-830	53	1	aliquots	aliquot	NOUN
admet-830	53	2	were	be	AUX
admet-830	53	3	analysed	analyse	VERB
admet-830	53	4	at	at	ADP
admet-830	53	5	24	24	NUM
admet-830	53	6	,	,	PUNCT
admet-830	53	7	48	48	NUM
admet-830	53	8	and	and	CCONJ
admet-830	53	9	72	72	NUM
admet-830	53	10	h	h	NOUN
admet-830	53	11	to	to	PART
admet-830	53	12	determine	determine	VERB
admet-830	53	13	whether	whether	SCONJ
admet-830	53	14	equilibrium	equilibrium	NOUN
admet-830	53	15	had	have	AUX
admet-830	53	16	been	be	AUX
admet-830	53	17	reached	reach	VERB
admet-830	53	18	.	.	PUNCT
admet-830	54	1	samples	sample	NOUN
admet-830	54	2	were	be	AUX
admet-830	54	3	centrifuged	centrifuge	VERB
admet-830	54	4	at	at	ADP
admet-830	54	5	29066	29066	NUM
admet-830	54	6	×	×	NOUN
admet-830	54	7	g	g	NOUN
admet-830	54	8	for	for	ADP
admet-830	54	9	20	20	NUM
admet-830	54	10	min	min	NOUN
admet-830	54	11	at	at	ADP
admet-830	54	12	24	24	NUM
admet-830	54	13	°	°	NOUN
admet-830	54	14	c	c	NOUN
admet-830	54	15	to	to	PART
admet-830	54	16	separate	separate	VERB
admet-830	54	17	any	any	DET
admet-830	54	18	undissolved	undissolve	VERB
admet-830	54	19	drug	drug	NOUN
admet-830	54	20	.	.	PUNCT
admet-830	55	1	solvent	solvent	ADJ
admet-830	55	2	extraction	extraction	NOUN
admet-830	55	3	was	be	AUX
admet-830	55	4	performed	perform	VERB
admet-830	55	5	to	to	PART
admet-830	55	6	extract	extract	VERB
admet-830	55	7	the	the	DET
admet-830	55	8	drug	drug	NOUN
admet-830	55	9	from	from	ADP
admet-830	55	10	the	the	DET
admet-830	55	11	lipid	lipid	NOUN
admet-830	55	12	supernatant	supernatant	NOUN
admet-830	55	13	by	by	ADP
admet-830	55	14	diluting	dilute	VERB
admet-830	55	15	the	the	DET
admet-830	55	16	lipid	lipid	NOUN
admet-830	55	17	supernatant	supernatant	NOUN
admet-830	55	18	with	with	ADP
admet-830	55	19	methanol	methanol	NOUN
admet-830	55	20	(	(	PUNCT
admet-830	55	21	100	100	NUM
admet-830	55	22	-	-	ADJ
admet-830	55	23	fold	fold	ADJ
admet-830	55	24	dilution	dilution	NOUN
admet-830	55	25	)	)	PUNCT
admet-830	55	26	and	and	CCONJ
admet-830	55	27	sonicating	sonicate	VERB
admet-830	55	28	for	for	ADP
admet-830	55	29	10	10	NUM
admet-830	55	30	min	min	NOUN
admet-830	55	31	,	,	PUNCT
admet-830	55	32	prior	prior	ADV
admet-830	55	33	to	to	ADP
admet-830	55	34	further	further	ADJ
admet-830	55	35	centrifugation	centrifugation	NOUN
admet-830	55	36	at	at	ADP
admet-830	55	37	29066	29066	NUM
admet-830	55	38	×	×	NOUN
admet-830	55	39	g	g	NOUN
admet-830	55	40	for	for	ADP
admet-830	55	41	10	10	NUM
admet-830	55	42	min	min	NOUN
admet-830	55	43	at	at	ADP
admet-830	55	44	24	24	NUM
admet-830	55	45	°	°	NOUN
admet-830	55	46	c	c	NOUN
admet-830	55	47	for	for	ADP
admet-830	55	48	phase	phase	NOUN
admet-830	55	49	separation	separation	NOUN
admet-830	55	50	.	.	PUNCT
admet-830	56	1	the	the	DET
admet-830	56	2	resulting	result	VERB
admet-830	56	3	supernatant	supernatant	NOUN
admet-830	56	4	was	be	AUX
admet-830	56	5	diluted	dilute	VERB
admet-830	56	6	appropriately	appropriately	ADV
admet-830	56	7	and	and	CCONJ
admet-830	56	8	analysed	analyse	VERB
admet-830	56	9	via	via	ADP
admet-830	56	10	hplc	hplc	NOUN
admet-830	56	11	.	.	PUNCT
admet-830	57	1	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	PROPN
admet-830	57	2	admet	admet	PROPN
admet-830	57	3	&	&	CCONJ
admet-830	57	4	dmpk	dmpk	PROPN
admet-830	57	5	8(4	8(4	NOUN
admet-830	57	6	)	)	PUNCT
admet-830	57	7	(	(	PUNCT
admet-830	57	8	2020	2020	NUM
admet-830	57	9	)	)	PUNCT
admet-830	57	10	437	437	NUM
admet-830	57	11	-	-	SYM
admet-830	57	12	451	451	NUM
admet-830	57	13	drug	drug	NOUN
admet-830	57	14	ionisation	ionisation	NOUN
admet-830	57	15	and	and	CCONJ
admet-830	57	16	lipid	lipid	NOUN
admet-830	57	17	-	-	PUNCT
admet-830	57	18	based	base	VERB
admet-830	57	19	formulations	formulation	NOUN
admet-830	57	20	doi	doi	NOUN
admet-830	57	21	:	:	PUNCT
admet-830	57	22	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	57	23	440	440	NUM
admet-830	57	24	submicron	submicron	NOUN
admet-830	57	25	lipid	lipid	NOUN
admet-830	57	26	emulsions	emulsion	NOUN
admet-830	57	27	with	with	ADP
admet-830	57	28	drug	drug	NOUN
admet-830	57	29	loaded	load	VERB
admet-830	57	30	into	into	ADP
admet-830	57	31	lipid	lipid	NOUN
admet-830	57	32	at	at	ADP
admet-830	57	33	80	80	NUM
admet-830	57	34	%	%	NOUN
admet-830	57	35	and	and	CCONJ
admet-830	57	36	100	100	NUM
admet-830	57	37	%	%	NOUN
admet-830	57	38	the	the	DET
admet-830	57	39	equilibrium	equilibrium	NOUN
admet-830	57	40	solubility	solubility	NOUN
admet-830	57	41	for	for	ADP
admet-830	57	42	ris	ris	PROPN
admet-830	57	43	and	and	CCONJ
admet-830	57	44	lur	lur	PROPN
admet-830	57	45	,	,	PUNCT
admet-830	57	46	respectively	respectively	ADV
admet-830	57	47	,	,	PUNCT
admet-830	57	48	were	be	AUX
admet-830	57	49	formulated	formulate	VERB
admet-830	57	50	.	.	PUNCT
admet-830	58	1	soybean	soybean	NOUN
admet-830	58	2	lecithin	lecithin	NOUN
admet-830	58	3	(	(	PUNCT
admet-830	58	4	6	6	NUM
admet-830	58	5	%	%	NOUN
admet-830	58	6	w	w	PROPN
admet-830	58	7	/	/	SYM
admet-830	58	8	w	w	NOUN
admet-830	58	9	)	)	PUNCT
admet-830	58	10	was	be	AUX
admet-830	58	11	dissolved	dissolve	VERB
admet-830	58	12	in	in	ADP
admet-830	58	13	capmul	capmul	PROPN
admet-830	58	14	®	®	PROPN
admet-830	58	15	mcm	mcm	PROPN
admet-830	58	16	with	with	ADP
admet-830	58	17	the	the	DET
admet-830	58	18	aid	aid	NOUN
admet-830	58	19	of	of	ADP
admet-830	58	20	sonication	sonication	NOUN
admet-830	58	21	.	.	PUNCT
admet-830	59	1	drug	drug	NOUN
admet-830	59	2	was	be	AUX
admet-830	59	3	dissolved	dissolve	VERB
admet-830	59	4	in	in	ADP
admet-830	59	5	the	the	DET
admet-830	59	6	lipid	lipid	NOUN
admet-830	59	7	prior	prior	ADV
admet-830	59	8	to	to	ADP
admet-830	59	9	the	the	DET
admet-830	59	10	addition	addition	NOUN
admet-830	59	11	of	of	ADP
admet-830	59	12	milli	milli	ADJ
admet-830	59	13	-	-	PUNCT
admet-830	59	14	q	q	NOUN
admet-830	59	15	water	water	NOUN
admet-830	59	16	.	.	PUNCT
admet-830	60	1	the	the	DET
admet-830	60	2	coarse	coarse	ADJ
admet-830	60	3	emulsions	emulsion	NOUN
admet-830	60	4	were	be	AUX
admet-830	60	5	sonicated	sonicate	VERB
admet-830	60	6	for	for	SCONJ
admet-830	60	7	1	1	NUM
admet-830	60	8	h	h	NOUN
admet-830	60	9	to	to	PART
admet-830	60	10	form	form	VERB
admet-830	60	11	submicron	submicron	NOUN
admet-830	60	12	emulsions	emulsion	NOUN
admet-830	60	13	.	.	PUNCT
admet-830	61	1	fabrication	fabrication	NOUN
admet-830	61	2	of	of	ADP
admet-830	61	3	drug	drug	NOUN
admet-830	61	4	loaded	load	VERB
admet-830	61	5	silica	silica	NOUN
admet-830	61	6	-	-	PUNCT
admet-830	61	7	lipid	lipid	NOUN
admet-830	61	8	hybrid	hybrid	ADJ
admet-830	61	9	microparticles	microparticle	NOUN
admet-830	61	10	slh	slh	NOUN
admet-830	61	11	microparticles	microparticle	NOUN
admet-830	61	12	were	be	AUX
admet-830	61	13	fabricated	fabricate	VERB
admet-830	61	14	following	follow	VERB
admet-830	61	15	a	a	DET
admet-830	61	16	two	two	NUM
admet-830	61	17	-	-	PUNCT
admet-830	61	18	stage	stage	NOUN
admet-830	61	19	process	process	NOUN
admet-830	61	20	modified	modify	VERB
admet-830	61	21	from	from	ADP
admet-830	61	22	tan	tan	PROPN
admet-830	61	23	et	et	PROPN
admet-830	61	24	al	al	PROPN
admet-830	61	25	.	.	PUNCT
admet-830	62	1	[	[	X
admet-830	62	2	14	14	NUM
admet-830	62	3	]	]	PUNCT
admet-830	62	4	.	.	PUNCT
admet-830	63	1	a	a	DET
admet-830	63	2	silica	silica	NOUN
admet-830	63	3	dispersion	dispersion	NOUN
admet-830	63	4	(	(	PUNCT
admet-830	63	5	5	5	NUM
admet-830	63	6	%	%	NOUN
admet-830	63	7	w	w	PROPN
admet-830	63	8	/	/	SYM
admet-830	63	9	v	v	NOUN
admet-830	63	10	)	)	PUNCT
admet-830	63	11	was	be	AUX
admet-830	63	12	added	add	VERB
admet-830	63	13	to	to	ADP
admet-830	63	14	the	the	DET
admet-830	63	15	drug	drug	NOUN
admet-830	63	16	-	-	PUNCT
admet-830	63	17	lipid	lipid	NOUN
admet-830	63	18	emulsions	emulsion	NOUN
admet-830	63	19	to	to	PART
admet-830	63	20	achieve	achieve	VERB
admet-830	63	21	a	a	DET
admet-830	63	22	lipid	lipid	NOUN
admet-830	63	23	to	to	PART
admet-830	63	24	silica	silica	VERB
admet-830	63	25	ratio	ratio	NOUN
admet-830	63	26	of	of	ADP
admet-830	63	27	1:1	1:1	NUM
admet-830	63	28	and	and	CCONJ
admet-830	63	29	1:2	1:2	NUM
admet-830	63	30	for	for	ADP
admet-830	63	31	ris	ris	PROPN
admet-830	63	32	and	and	CCONJ
admet-830	63	33	lur	lur	PROPN
admet-830	63	34	,	,	PUNCT
admet-830	63	35	respectively	respectively	ADV
admet-830	63	36	.	.	PUNCT
admet-830	64	1	the	the	DET
admet-830	64	2	silica	silica	NOUN
admet-830	64	3	-	-	PUNCT
admet-830	64	4	stabilised	stabilise	VERB
admet-830	64	5	pickering	pickering	NOUN
admet-830	64	6	emulsions	emulsion	NOUN
admet-830	64	7	were	be	AUX
admet-830	64	8	stirred	stir	VERB
admet-830	64	9	overnight	overnight	ADV
admet-830	64	10	at	at	ADP
admet-830	64	11	room	room	NOUN
admet-830	64	12	temperature	temperature	NOUN
admet-830	64	13	prior	prior	ADV
admet-830	64	14	to	to	ADP
admet-830	64	15	spray	spray	NOUN
admet-830	64	16	-	-	PUNCT
admet-830	64	17	drying	dry	VERB
admet-830	64	18	to	to	PART
admet-830	64	19	form	form	VERB
admet-830	64	20	solid	solid	ADJ
admet-830	64	21	slh	slh	ADJ
admet-830	64	22	microparticles	microparticle	NOUN
admet-830	64	23	(	(	PUNCT
admet-830	64	24	mini	mini	NOUN
admet-830	64	25	sprayer	sprayer	NOUN
admet-830	64	26	b-290	b-290	PROPN
admet-830	64	27	,	,	PUNCT
admet-830	64	28	büchi	büchi	PROPN
admet-830	64	29	labortechnik	labortechnik	X
admet-830	64	30	ag	ag	PROPN
admet-830	64	31	,	,	PUNCT
admet-830	64	32	switzerland	switzerland	PROPN
admet-830	64	33	)	)	PUNCT
admet-830	64	34	.	.	PUNCT
admet-830	65	1	processing	processing	NOUN
admet-830	65	2	parameters	parameter	NOUN
admet-830	65	3	were	be	AUX
admet-830	65	4	as	as	SCONJ
admet-830	65	5	follows	follow	VERB
admet-830	65	6	:	:	PUNCT
admet-830	65	7	inlet	inlet	VERB
admet-830	65	8	temperature	temperature	NOUN
admet-830	65	9	of	of	ADP
admet-830	65	10	160	160	NUM
admet-830	65	11	°	°	NOUN
admet-830	65	12	c	c	NOUN
admet-830	65	13	,	,	PUNCT
admet-830	65	14	aspirator	aspirator	NOUN
admet-830	65	15	setting	set	VERB
admet-830	65	16	at	at	ADP
admet-830	65	17	100	100	NUM
admet-830	65	18	%	%	NOUN
admet-830	65	19	,	,	PUNCT
admet-830	65	20	pump	pump	NOUN
admet-830	65	21	setting	set	VERB
admet-830	65	22	at	at	ADP
admet-830	65	23	20	20	NUM
admet-830	65	24	%	%	NOUN
admet-830	65	25	and	and	CCONJ
admet-830	65	26	an	an	DET
admet-830	65	27	outlet	outlet	NOUN
admet-830	65	28	temperature	temperature	NOUN
admet-830	65	29	of	of	ADP
admet-830	65	30	approximately	approximately	ADV
admet-830	65	31	65	65	NUM
admet-830	65	32	°	°	NOUN
admet-830	65	33	c	c	NOUN
admet-830	65	34	.	.	PUNCT
admet-830	66	1	physicochemical	physicochemical	ADJ
admet-830	66	2	characterisation	characterisation	NOUN
admet-830	66	3	the	the	DET
admet-830	66	4	drug	drug	NOUN
admet-830	66	5	content	content	NOUN
admet-830	66	6	of	of	ADP
admet-830	66	7	the	the	DET
admet-830	66	8	slh	slh	PROPN
admet-830	66	9	formulations	formulation	NOUN
admet-830	66	10	were	be	AUX
admet-830	66	11	determined	determine	VERB
admet-830	66	12	by	by	ADP
admet-830	66	13	a	a	DET
admet-830	66	14	solvent	solvent	ADJ
admet-830	66	15	extraction	extraction	NOUN
admet-830	66	16	method	method	NOUN
admet-830	66	17	.	.	PUNCT
admet-830	67	1	approximately	approximately	ADV
admet-830	67	2	10	10	NUM
admet-830	67	3	mg	mg	NOUN
admet-830	67	4	of	of	ADP
admet-830	67	5	powder	powder	NOUN
admet-830	67	6	was	be	AUX
admet-830	67	7	dispersed	disperse	VERB
admet-830	67	8	in	in	ADP
admet-830	67	9	10	10	NUM
admet-830	67	10	ml	ml	NOUN
admet-830	67	11	of	of	ADP
admet-830	67	12	methanol	methanol	NOUN
admet-830	67	13	.	.	PUNCT
admet-830	68	1	the	the	DET
admet-830	68	2	dispersion	dispersion	NOUN
admet-830	68	3	was	be	AUX
admet-830	68	4	sonicated	sonicate	VERB
admet-830	68	5	for	for	ADP
admet-830	68	6	45	45	NUM
admet-830	68	7	min	min	NOUN
admet-830	68	8	and	and	CCONJ
admet-830	68	9	centrifuged	centrifuge	VERB
admet-830	68	10	at	at	ADP
admet-830	68	11	29066	29066	NUM
admet-830	68	12	×	×	NOUN
admet-830	68	13	g	g	NOUN
admet-830	68	14	for	for	ADP
admet-830	68	15	20	20	NUM
admet-830	68	16	min	min	NOUN
admet-830	68	17	at	at	ADP
admet-830	68	18	24	24	NUM
admet-830	68	19	°	°	NOUN
admet-830	68	20	c	c	NOUN
admet-830	68	21	,	,	PUNCT
admet-830	68	22	prior	prior	ADV
admet-830	68	23	to	to	ADP
admet-830	68	24	dilution	dilution	NOUN
admet-830	68	25	for	for	ADP
admet-830	68	26	hplc	hplc	NOUN
admet-830	68	27	analysis	analysis	NOUN
admet-830	68	28	.	.	PUNCT
admet-830	69	1	the	the	DET
admet-830	69	2	particle	particle	NOUN
admet-830	69	3	size	size	NOUN
admet-830	69	4	of	of	ADP
admet-830	69	5	the	the	DET
admet-830	69	6	slh	slh	PROPN
admet-830	69	7	formulations	formulation	NOUN
admet-830	69	8	were	be	AUX
admet-830	69	9	analysed	analyse	VERB
admet-830	69	10	using	use	VERB
admet-830	69	11	a	a	DET
admet-830	69	12	malvern	malvern	ADJ
admet-830	69	13	mastersizer	mastersizer	NOUN
admet-830	69	14	3000	3000	NUM
admet-830	69	15	hydro	hydro	NOUN
admet-830	69	16	lv	lv	PROPN
admet-830	69	17	(	(	PUNCT
admet-830	69	18	malvern	malvern	PROPN
admet-830	69	19	,	,	PUNCT
admet-830	69	20	united	united	ADJ
admet-830	69	21	kingdom	kingdom	PROPN
admet-830	69	22	)	)	PUNCT
admet-830	69	23	.	.	PUNCT
admet-830	70	1	formulations	formulation	NOUN
admet-830	70	2	were	be	AUX
admet-830	70	3	added	add	VERB
admet-830	70	4	to	to	ADP
admet-830	70	5	the	the	DET
admet-830	70	6	sample	sample	NOUN
admet-830	70	7	vessel	vessel	NOUN
admet-830	70	8	until	until	SCONJ
admet-830	70	9	a	a	DET
admet-830	70	10	laser	laser	NOUN
admet-830	70	11	obscuration	obscuration	NOUN
admet-830	70	12	of	of	ADP
admet-830	70	13	1020	1020	NUM
admet-830	70	14	%	%	NOUN
admet-830	70	15	was	be	AUX
admet-830	70	16	achieved	achieve	VERB
admet-830	70	17	.	.	PUNCT
admet-830	71	1	a	a	DET
admet-830	71	2	particle	particle	NOUN
admet-830	71	3	refractive	refractive	ADJ
admet-830	71	4	index	index	NOUN
admet-830	71	5	of	of	ADP
admet-830	71	6	1.54	1.54	NUM
admet-830	71	7	was	be	AUX
admet-830	71	8	utilised	utilise	VERB
admet-830	71	9	.	.	PUNCT
admet-830	72	1	results	result	NOUN
admet-830	72	2	are	be	AUX
admet-830	72	3	expressed	express	VERB
admet-830	72	4	as	as	ADP
admet-830	72	5	volume	volume	NOUN
admet-830	72	6	diameter	diameter	NOUN
admet-830	72	7	(	(	PUNCT
admet-830	72	8	µm	µm	NOUN
admet-830	72	9	)	)	PUNCT
admet-830	72	10	at	at	ADP
admet-830	72	11	50	50	NUM
admet-830	72	12	%	%	NOUN
admet-830	72	13	cumulative	cumulative	ADJ
admet-830	72	14	volume	volume	NOUN
admet-830	72	15	(	(	PUNCT
admet-830	72	16	d	d	X
admet-830	72	17	(	(	PUNCT
admet-830	72	18	v.0.5	v.0.5	NOUN
admet-830	72	19	)	)	PUNCT
admet-830	72	20	)	)	PUNCT
admet-830	72	21	.	.	PUNCT
admet-830	73	1	the	the	DET
admet-830	73	2	surface	surface	NOUN
admet-830	73	3	morphologies	morphology	NOUN
admet-830	73	4	of	of	ADP
admet-830	73	5	the	the	DET
admet-830	73	6	formulations	formulation	NOUN
admet-830	73	7	were	be	AUX
admet-830	73	8	analysed	analyse	VERB
admet-830	73	9	through	through	ADP
admet-830	73	10	high	high	ADJ
admet-830	73	11	-	-	PUNCT
admet-830	73	12	resolution	resolution	NOUN
admet-830	73	13	analytical	analytical	ADJ
admet-830	73	14	scanning	scanning	NOUN
admet-830	73	15	electron	electron	NOUN
admet-830	73	16	microscopy	microscopy	NOUN
admet-830	73	17	(	(	PUNCT
admet-830	73	18	sem	sem	NOUN
admet-830	73	19	)	)	PUNCT
admet-830	73	20	(	(	PUNCT
admet-830	73	21	carl	carl	PROPN
admet-830	73	22	ziess	ziess	PROPN
admet-830	73	23	microscopy	microscopy	PROPN
admet-830	73	24	merlin	merlin	PROPN
admet-830	73	25	with	with	ADP
admet-830	73	26	a	a	DET
admet-830	73	27	gemini	gemini	PROPN
admet-830	73	28	ii	ii	PROPN
admet-830	73	29	column	column	PROPN
admet-830	73	30	,	,	PUNCT
admet-830	73	31	germany	germany	PROPN
admet-830	73	32	)	)	PUNCT
admet-830	73	33	at	at	ADP
admet-830	73	34	an	an	DET
admet-830	73	35	accelerating	accelerate	VERB
admet-830	73	36	voltage	voltage	NOUN
admet-830	73	37	of	of	ADP
admet-830	73	38	8	8	NUM
admet-830	73	39	kv	kv	NOUN
admet-830	73	40	and	and	CCONJ
admet-830	73	41	spot	spot	NOUN
admet-830	73	42	size	size	NOUN
admet-830	73	43	of	of	ADP
admet-830	73	44	3	3	NUM
admet-830	73	45	-	-	SYM
admet-830	73	46	10	10	NUM
admet-830	73	47	μm	μm	NOUN
admet-830	73	48	.	.	PUNCT
admet-830	74	1	samples	sample	NOUN
admet-830	74	2	were	be	AUX
admet-830	74	3	attached	attach	VERB
admet-830	74	4	to	to	ADP
admet-830	74	5	double	double	ADJ
admet-830	74	6	-	-	PUNCT
admet-830	74	7	faced	faced	ADJ
admet-830	74	8	adhesive	adhesive	ADJ
admet-830	74	9	tape	tape	NOUN
admet-830	74	10	and	and	CCONJ
admet-830	74	11	sputter	sputter	VERB
admet-830	74	12	coated	coat	VERB
admet-830	74	13	with	with	ADP
admet-830	74	14	gold	gold	NOUN
admet-830	74	15	(	(	PUNCT
admet-830	74	16	5	5	NUM
admet-830	74	17	-	-	SYM
admet-830	74	18	10	10	NUM
admet-830	74	19	nm	nm	ADJ
admet-830	74	20	thickness	thickness	NOUN
admet-830	74	21	)	)	PUNCT
admet-830	74	22	prior	prior	ADV
admet-830	74	23	to	to	ADP
admet-830	74	24	imaging	imaging	NOUN
admet-830	74	25	.	.	PUNCT
admet-830	75	1	the	the	DET
admet-830	75	2	crystallinity	crystallinity	NOUN
admet-830	75	3	of	of	ADP
admet-830	75	4	encapsulated	encapsulate	VERB
admet-830	75	5	drug	drug	NOUN
admet-830	75	6	was	be	AUX
admet-830	75	7	analysed	analyse	VERB
admet-830	75	8	via	via	ADP
admet-830	75	9	differential	differential	NOUN
admet-830	75	10	scanning	scanning	NOUN
admet-830	75	11	calorimetry	calorimetry	NOUN
admet-830	75	12	(	(	PUNCT
admet-830	75	13	dsc	dsc	PROPN
admet-830	75	14	q100	q100	PROPN
admet-830	75	15	,	,	PUNCT
admet-830	75	16	ta	ta	PROPN
admet-830	75	17	instruments	instrument	NOUN
admet-830	75	18	,	,	PUNCT
admet-830	75	19	australia	australia	PROPN
admet-830	75	20	)	)	PUNCT
admet-830	75	21	.	.	PUNCT
admet-830	76	1	approximately	approximately	ADV
admet-830	76	2	2	2	NUM
admet-830	76	3	mg	mg	NOUN
admet-830	76	4	of	of	ADP
admet-830	76	5	slh	slh	PROPN
admet-830	76	6	was	be	AUX
admet-830	76	7	hermetically	hermetically	ADV
admet-830	76	8	sealed	seal	VERB
admet-830	76	9	in	in	ADP
admet-830	76	10	aluminium	aluminium	NOUN
admet-830	76	11	pans	pan	NOUN
admet-830	76	12	and	and	CCONJ
admet-830	76	13	heated	heat	VERB
admet-830	76	14	at	at	ADP
admet-830	76	15	a	a	DET
admet-830	76	16	rate	rate	NOUN
admet-830	76	17	of	of	ADP
admet-830	76	18	10	10	NUM
admet-830	76	19	°	°	NOUN
admet-830	76	20	c	c	NOUN
admet-830	76	21	/	/	SYM
admet-830	76	22	min	min	NOUN
admet-830	76	23	from	from	ADP
admet-830	76	24	25	25	NUM
admet-830	76	25	°	°	NOUN
admet-830	76	26	c	c	NOUN
admet-830	76	27	to	to	ADP
admet-830	76	28	170	170	NUM
admet-830	76	29	°	°	ADP
admet-830	76	30	c	c	NOUN
admet-830	76	31	for	for	ADP
admet-830	76	32	lur	lur	PROPN
admet-830	76	33	and	and	CCONJ
admet-830	76	34	200	200	NUM
admet-830	76	35	°	°	NOUN
admet-830	76	36	c	c	NOUN
admet-830	76	37	for	for	ADP
admet-830	76	38	ris	ris	PROPN
admet-830	76	39	,	,	PUNCT
admet-830	76	40	under	under	ADP
admet-830	76	41	nitrogen	nitrogen	NOUN
admet-830	76	42	(	(	PUNCT
admet-830	76	43	80	80	NUM
admet-830	76	44	ml	ml	NOUN
admet-830	76	45	/	/	SYM
admet-830	76	46	min	min	NOUN
admet-830	76	47	)	)	PUNCT
admet-830	76	48	.	.	PUNCT
admet-830	77	1	in	in	ADP
admet-830	77	2	vitro	vitro	X
admet-830	77	3	dissolution	dissolution	NOUN
admet-830	77	4	and	and	CCONJ
admet-830	77	5	release	release	VERB
admet-830	77	6	studies	study	NOUN
admet-830	77	7	in	in	ADP
admet-830	77	8	vitro	vitro	X
admet-830	77	9	dissolution	dissolution	NOUN
admet-830	77	10	and	and	CCONJ
admet-830	77	11	release	release	NOUN
admet-830	77	12	studies	study	NOUN
admet-830	77	13	were	be	AUX
admet-830	77	14	performed	perform	VERB
admet-830	77	15	under	under	ADP
admet-830	77	16	non	non	ADJ
admet-830	77	17	-	-	ADJ
admet-830	77	18	sink	sink	ADJ
admet-830	77	19	conditions	condition	NOUN
admet-830	77	20	using	use	VERB
admet-830	77	21	a	a	DET
admet-830	77	22	usp	usp	NOUN
admet-830	77	23	type	type	NOUN
admet-830	77	24	ii	ii	NOUN
admet-830	77	25	apparatus	apparatus	NOUN
admet-830	77	26	operating	operate	VERB
admet-830	77	27	at	at	ADP
admet-830	77	28	50	50	NUM
admet-830	77	29	rpm	rpm	NOUN
admet-830	77	30	.	.	PUNCT
admet-830	78	1	formulations	formulation	NOUN
admet-830	78	2	equivalent	equivalent	ADJ
admet-830	78	3	to	to	ADP
admet-830	78	4	10	10	NUM
admet-830	78	5	mg	mg	NOUN
admet-830	78	6	ris	ris	PROPN
admet-830	78	7	and	and	CCONJ
admet-830	78	8	5	5	NUM
admet-830	78	9	mg	mg	PROPN
admet-830	78	10	lur	lur	PROPN
admet-830	78	11	were	be	AUX
admet-830	78	12	added	add	VERB
admet-830	78	13	to	to	ADP
admet-830	78	14	ph	ph	ADJ
admet-830	78	15	7.4	7.4	NUM
admet-830	78	16	phosphate	phosphate	NOUN
admet-830	78	17	buffer	buffer	NOUN
admet-830	78	18	containing	contain	VERB
admet-830	78	19	1	1	NUM
admet-830	78	20	%	%	NOUN
admet-830	78	21	w	w	NOUN
admet-830	78	22	/	/	SYM
admet-830	78	23	v	v	NOUN
admet-830	78	24	tween	tween	NOUN
admet-830	78	25	80	80	NUM
admet-830	78	26	,	,	PUNCT
admet-830	78	27	maintained	maintain	VERB
admet-830	78	28	at	at	ADP
admet-830	78	29	37	37	NUM
admet-830	78	30	°	°	NOUN
admet-830	78	31	c	c	NOUN
admet-830	78	32	.	.	PUNCT
admet-830	79	1	aliquots	aliquot	NOUN
admet-830	79	2	were	be	AUX
admet-830	79	3	taken	take	VERB
admet-830	79	4	at	at	ADP
admet-830	79	5	pre	pre	ADJ
admet-830	79	6	-	-	ADJ
admet-830	79	7	determined	determined	ADJ
admet-830	79	8	time	time	NOUN
admet-830	79	9	points	point	NOUN
admet-830	79	10	and	and	CCONJ
admet-830	79	11	replaced	replace	VERB
admet-830	79	12	with	with	ADP
admet-830	79	13	an	an	DET
admet-830	79	14	equal	equal	ADJ
admet-830	79	15	volume	volume	NOUN
admet-830	79	16	of	of	ADP
admet-830	79	17	fresh	fresh	ADJ
admet-830	79	18	media	medium	NOUN
admet-830	79	19	.	.	PUNCT
admet-830	80	1	samples	sample	NOUN
admet-830	80	2	were	be	AUX
admet-830	80	3	immediately	immediately	ADV
admet-830	80	4	centrifuged	centrifuge	VERB
admet-830	80	5	at	at	ADP
admet-830	80	6	29066	29066	NUM
admet-830	80	7	×	×	NOUN
admet-830	80	8	g	g	NOUN
admet-830	80	9	for	for	ADP
admet-830	80	10	10	10	NUM
admet-830	80	11	min	min	NOUN
admet-830	80	12	at	at	ADP
admet-830	80	13	24	24	NUM
admet-830	80	14	°	°	NOUN
admet-830	80	15	c	c	NOUN
admet-830	80	16	.	.	PUNCT
admet-830	81	1	the	the	DET
admet-830	81	2	supernatant	supernatant	NOUN
admet-830	81	3	was	be	AUX
admet-830	81	4	diluted	dilute	VERB
admet-830	81	5	appropriately	appropriately	ADV
admet-830	81	6	with	with	ADP
admet-830	81	7	mobile	mobile	ADJ
admet-830	81	8	phase	phase	NOUN
admet-830	81	9	for	for	ADP
admet-830	81	10	hplc	hplc	NOUN
admet-830	81	11	analysis	analysis	NOUN
admet-830	81	12	.	.	PUNCT
admet-830	82	1	to	to	PART
admet-830	82	2	study	study	VERB
admet-830	82	3	the	the	DET
admet-830	82	4	interaction	interaction	NOUN
admet-830	82	5	between	between	ADP
admet-830	82	6	ris	ris	PROPN
admet-830	82	7	and	and	CCONJ
admet-830	82	8	silica	silica	NOUN
admet-830	82	9	,	,	PUNCT
admet-830	82	10	excess	excess	ADJ
admet-830	82	11	ris	ris	PROPN
admet-830	82	12	was	be	AUX
admet-830	82	13	added	add	VERB
admet-830	82	14	to	to	ADP
admet-830	82	15	the	the	DET
admet-830	82	16	ph	ph	ADJ
admet-830	82	17	7.4	7.4	NUM
admet-830	82	18	phosphate	phosphate	NOUN
admet-830	82	19	buffer	buffer	NOUN
admet-830	82	20	containing	contain	VERB
admet-830	82	21	1	1	NUM
admet-830	82	22	%	%	NOUN
admet-830	82	23	w	w	PROPN
admet-830	82	24	/	/	SYM
admet-830	82	25	v	v	NOUN
admet-830	82	26	tween	tween	NOUN
admet-830	82	27	80	80	NUM
admet-830	82	28	in	in	ADP
admet-830	82	29	a	a	DET
admet-830	82	30	glass	glass	NOUN
admet-830	82	31	vial	vial	NOUN
admet-830	82	32	and	and	CCONJ
admet-830	82	33	sonicated	sonicate	VERB
admet-830	82	34	for	for	SCONJ
admet-830	82	35	1	1	NUM
admet-830	82	36	h	h	NOUN
admet-830	82	37	to	to	PART
admet-830	82	38	facilitate	facilitate	VERB
admet-830	82	39	dissolution	dissolution	NOUN
admet-830	82	40	.	.	PUNCT
admet-830	83	1	temperature	temperature	NOUN
admet-830	83	2	was	be	AUX
admet-830	83	3	maintained	maintain	VERB
admet-830	83	4	at	at	ADP
admet-830	83	5	37	37	NUM
admet-830	83	6	°	°	NOUN
admet-830	83	7	c	c	NOUN
admet-830	83	8	by	by	ADP
admet-830	83	9	manual	manual	ADJ
admet-830	83	10	adjustment	adjustment	NOUN
admet-830	83	11	.	.	PUNCT
admet-830	84	1	vials	vial	NOUN
admet-830	84	2	were	be	AUX
admet-830	84	3	rotated	rotate	VERB
admet-830	84	4	at	at	ADP
admet-830	84	5	37	37	NUM
admet-830	84	6	°	°	NOUN
admet-830	84	7	c	c	NOUN
admet-830	84	8	for	for	ADP
admet-830	84	9	an	an	DET
admet-830	84	10	additional	additional	ADJ
admet-830	84	11	20	20	NUM
admet-830	84	12	min	min	NOUN
admet-830	84	13	and	and	CCONJ
admet-830	84	14	an	an	DET
admet-830	84	15	aliquot	aliquot	NOUN
admet-830	84	16	was	be	AUX
admet-830	84	17	taken	take	VERB
admet-830	84	18	.	.	PUNCT
admet-830	85	1	aerosil	aerosil	NOUN
admet-830	85	2	®	®	NOUN
admet-830	85	3	300	300	NUM
admet-830	85	4	silica	silica	NOUN
admet-830	85	5	nanoparticles	nanoparticle	NOUN
admet-830	85	6	(	(	PUNCT
admet-830	85	7	equivalent	equivalent	ADJ
admet-830	85	8	mass	mass	NOUN
admet-830	85	9	to	to	PART
admet-830	85	10	slh	slh	PROPN
admet-830	85	11	content	content	PROPN
admet-830	85	12	)	)	PUNCT
admet-830	85	13	were	be	AUX
admet-830	85	14	added	add	VERB
admet-830	85	15	to	to	ADP
admet-830	85	16	the	the	DET
admet-830	85	17	vial	vial	ADJ
admet-830	85	18	and	and	CCONJ
admet-830	85	19	further	further	ADJ
admet-830	85	20	aliquots	aliquot	NOUN
admet-830	85	21	were	be	AUX
admet-830	85	22	taken	take	VERB
admet-830	85	23	at	at	ADP
admet-830	85	24	pre	pre	ADJ
admet-830	85	25	-	-	ADJ
admet-830	85	26	determined	determined	ADJ
admet-830	85	27	time	time	NOUN
admet-830	85	28	points	point	NOUN
admet-830	85	29	.	.	PUNCT
admet-830	86	1	samples	sample	NOUN
admet-830	86	2	were	be	AUX
admet-830	86	3	centrifuged	centrifuge	VERB
admet-830	86	4	at	at	ADP
admet-830	86	5	29066	29066	NUM
admet-830	86	6	×	×	NOUN
admet-830	86	7	g	g	NOUN
admet-830	86	8	for	for	ADP
admet-830	86	9	10	10	NUM
admet-830	86	10	min	min	NOUN
admet-830	86	11	at	at	ADP
admet-830	86	12	24	24	NUM
admet-830	86	13	°	°	NOUN
admet-830	86	14	c	c	NOUN
admet-830	86	15	,	,	PUNCT
admet-830	86	16	and	and	CCONJ
admet-830	86	17	the	the	DET
admet-830	86	18	resulting	result	VERB
admet-830	86	19	supernatant	supernatant	NOUN
admet-830	86	20	was	be	AUX
admet-830	86	21	diluted	dilute	VERB
admet-830	86	22	prior	prior	ADV
admet-830	86	23	to	to	ADP
admet-830	86	24	hplc	hplc	NOUN
admet-830	86	25	analysis	analysis	NOUN
admet-830	86	26	.	.	PUNCT
admet-830	87	1	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	87	2	admet	admet	PROPN
admet-830	87	3	&	&	CCONJ
admet-830	87	4	dmpk	dmpk	PROPN
admet-830	87	5	8(4	8(4	NOUN
admet-830	87	6	)	)	PUNCT
admet-830	87	7	(	(	PUNCT
admet-830	87	8	2020	2020	NUM
admet-830	87	9	)	)	PUNCT
admet-830	87	10	437	437	NUM
admet-830	87	11	-	-	SYM
admet-830	87	12	451	451	NUM
admet-830	87	13	drug	drug	NOUN
admet-830	87	14	ionisation	ionisation	NOUN
admet-830	87	15	and	and	CCONJ
admet-830	87	16	lipid	lipid	NOUN
admet-830	87	17	-	-	PUNCT
admet-830	87	18	based	base	VERB
admet-830	87	19	formulations	formulation	NOUN
admet-830	87	20	doi	doi	NOUN
admet-830	87	21	:	:	PUNCT
admet-830	87	22	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	87	23	441	441	NUM
admet-830	87	24	solubilisation	solubilisation	NOUN
admet-830	87	25	studies	study	NOUN
admet-830	87	26	under	under	ADP
admet-830	87	27	digesting	digest	VERB
admet-830	87	28	conditions	condition	NOUN
admet-830	87	29	during	during	ADP
admet-830	87	30	in	in	ADP
admet-830	87	31	vitro	vitro	X
admet-830	87	32	lipolysis	lipolysis	NOUN
admet-830	87	33	simulated	simulate	VERB
admet-830	87	34	fasted	fast	VERB
admet-830	87	35	-	-	PUNCT
admet-830	87	36	state	state	NOUN
admet-830	87	37	intestinal	intestinal	ADJ
admet-830	87	38	media	medium	NOUN
admet-830	87	39	was	be	AUX
admet-830	87	40	prepared	prepare	VERB
admet-830	87	41	using	use	VERB
admet-830	87	42	a	a	DET
admet-830	87	43	method	method	NOUN
admet-830	87	44	previously	previously	ADV
admet-830	87	45	developed	develop	VERB
admet-830	87	46	by	by	ADP
admet-830	87	47	sek	sek	PROPN
admet-830	87	48	et	et	PROPN
admet-830	87	49	al	al	PROPN
admet-830	87	50	.	.	PUNCT
admet-830	88	1	[	[	X
admet-830	88	2	25	25	NUM
admet-830	88	3	]	]	PUNCT
admet-830	88	4	.	.	PUNCT
admet-830	88	5	mixed	mix	VERB
admet-830	88	6	fasted	fast	VERB
admet-830	88	7	-	-	PUNCT
admet-830	88	8	state	state	NOUN
admet-830	88	9	micelles	micelle	NOUN
admet-830	88	10	with	with	ADP
admet-830	88	11	a	a	DET
admet-830	88	12	bile	bile	NOUN
admet-830	88	13	salt	salt	NOUN
admet-830	88	14	:	:	PUNCT
admet-830	88	15	phosphatidylcholine	phosphatidylcholine	NOUN
admet-830	88	16	concentration	concentration	NOUN
admet-830	88	17	of	of	ADP
admet-830	88	18	5	5	NUM
admet-830	88	19	mm	mm	NOUN
admet-830	88	20	:	:	PUNCT
admet-830	88	21	1.25	1.25	NUM
admet-830	88	22	mm	mm	NOUN
admet-830	88	23	were	be	AUX
admet-830	88	24	prepared	prepare	VERB
admet-830	88	25	via	via	ADP
admet-830	88	26	the	the	DET
admet-830	88	27	following	follow	VERB
admet-830	88	28	procedure	procedure	NOUN
admet-830	88	29	.	.	PUNCT
admet-830	89	1	egg	egg	NOUN
admet-830	89	2	lecithin	lecithin	NOUN
admet-830	89	3	was	be	AUX
admet-830	89	4	dissolved	dissolve	VERB
admet-830	89	5	in	in	ADP
admet-830	89	6	chloroform	chloroform	NOUN
admet-830	89	7	prior	prior	ADV
admet-830	89	8	to	to	ADP
admet-830	89	9	evaporation	evaporation	NOUN
admet-830	89	10	to	to	PART
admet-830	89	11	form	form	VERB
admet-830	89	12	a	a	DET
admet-830	89	13	thin	thin	ADJ
admet-830	89	14	,	,	PUNCT
admet-830	89	15	dry	dry	ADJ
admet-830	89	16	lecithin	lecithin	NOUN
admet-830	89	17	film	film	NOUN
admet-830	89	18	.	.	PUNCT
admet-830	90	1	natdc	natdc	NOUN
admet-830	90	2	and	and	CCONJ
admet-830	90	3	digestion	digestion	NOUN
admet-830	90	4	buffer	buffer	NOUN
admet-830	90	5	(	(	PUNCT
admet-830	90	6	consisting	consist	VERB
admet-830	90	7	of	of	ADP
admet-830	90	8	50	50	NUM
admet-830	90	9	mm	mm	NOUN
admet-830	90	10	trizma	trizma	PROPN
admet-830	90	11	®	®	NOUN
admet-830	90	12	maleate	maleate	NOUN
admet-830	90	13	,	,	PUNCT
admet-830	90	14	150	150	NUM
admet-830	90	15	mm	mm	NOUN
admet-830	90	16	sodium	sodium	NOUN
admet-830	90	17	chloride	chloride	NOUN
admet-830	90	18	and	and	CCONJ
admet-830	90	19	5	5	NUM
admet-830	90	20	mm	mm	NOUN
admet-830	90	21	calcium	calcium	NOUN
admet-830	90	22	chloride	chloride	NOUN
admet-830	90	23	)	)	PUNCT
admet-830	90	24	were	be	AUX
admet-830	90	25	added	add	VERB
admet-830	90	26	,	,	PUNCT
admet-830	90	27	and	and	CCONJ
admet-830	90	28	the	the	DET
admet-830	90	29	mixture	mixture	NOUN
admet-830	90	30	was	be	AUX
admet-830	90	31	left	leave	VERB
admet-830	90	32	to	to	PART
admet-830	90	33	stir	stir	VERB
admet-830	90	34	overnight	overnight	ADV
admet-830	90	35	to	to	PART
admet-830	90	36	produce	produce	VERB
admet-830	90	37	a	a	DET
admet-830	90	38	clear	clear	ADJ
admet-830	90	39	micellar	micellar	ADJ
admet-830	90	40	solution	solution	NOUN
admet-830	90	41	.	.	PUNCT
admet-830	91	1	in	in	ADP
admet-830	91	2	vitro	vitro	X
admet-830	91	3	lipolysis	lipolysis	NOUN
admet-830	91	4	was	be	AUX
admet-830	91	5	performed	perform	VERB
admet-830	91	6	using	use	VERB
admet-830	91	7	a	a	DET
admet-830	91	8	902	902	NUM
admet-830	91	9	titrando	titrando	ADJ
admet-830	91	10	ph	ph	ADJ
admet-830	91	11	-	-	PUNCT
admet-830	91	12	stat	stat	NOUN
admet-830	91	13	titration	titration	NOUN
admet-830	91	14	apparatus	apparatus	NOUN
admet-830	91	15	(	(	PUNCT
admet-830	91	16	metrohm	metrohm	PROPN
admet-830	91	17	,	,	PUNCT
admet-830	91	18	switzerland	switzerland	PROPN
admet-830	91	19	)	)	PUNCT
admet-830	91	20	.	.	PUNCT
admet-830	92	1	formulations	formulation	NOUN
admet-830	92	2	equivalent	equivalent	ADJ
admet-830	92	3	to	to	ADP
admet-830	92	4	5	5	NUM
admet-830	92	5	mg	mg	PROPN
admet-830	92	6	lur	lur	PROPN
admet-830	92	7	or	or	CCONJ
admet-830	92	8	ris	ris	X
admet-830	92	9	(	(	PUNCT
admet-830	92	10	357	357	NUM
admet-830	92	11	µl	µl	NOUN
admet-830	92	12	for	for	ADP
admet-830	92	13	lur	lur	NOUN
admet-830	92	14	emulsion	emulsion	NOUN
admet-830	92	15	,	,	PUNCT
admet-830	92	16	667	667	NUM
admet-830	92	17	mg	mg	NOUN
admet-830	92	18	for	for	ADP
admet-830	92	19	lur	lur	PROPN
admet-830	92	20	slh	slh	PROPN
admet-830	92	21	,	,	PUNCT
admet-830	92	22	160	160	NUM
admet-830	92	23	ul	ul	INTJ
admet-830	92	24	for	for	ADP
admet-830	92	25	ris	ris	X
admet-830	92	26	emulsion	emulsion	NOUN
admet-830	92	27	and	and	CCONJ
admet-830	92	28	305	305	NUM
admet-830	92	29	mg	mg	NOUN
admet-830	92	30	for	for	ADP
admet-830	92	31	ris	ris	PROPN
admet-830	92	32	slh	slh	PROPN
admet-830	92	33	)	)	PUNCT
admet-830	92	34	were	be	AUX
admet-830	92	35	added	add	VERB
admet-830	92	36	to	to	ADP
admet-830	92	37	18	18	NUM
admet-830	92	38	ml	ml	NOUN
admet-830	92	39	of	of	ADP
admet-830	92	40	fasted	fast	VERB
admet-830	92	41	-	-	PUNCT
admet-830	92	42	state	state	NOUN
admet-830	92	43	micelles	micelle	NOUN
admet-830	92	44	,	,	PUNCT
admet-830	92	45	stirred	stir	VERB
admet-830	92	46	and	and	CCONJ
admet-830	92	47	maintained	maintain	VERB
admet-830	92	48	at	at	ADP
admet-830	92	49	37	37	NUM
admet-830	92	50	°	°	NOUN
admet-830	92	51	c	c	NOUN
admet-830	92	52	in	in	ADP
admet-830	92	53	a	a	DET
admet-830	92	54	jacketed	jacketed	ADJ
admet-830	92	55	vessel	vessel	NOUN
admet-830	92	56	.	.	PUNCT
admet-830	93	1	lipolysis	lipolysis	NOUN
admet-830	93	2	was	be	AUX
admet-830	93	3	initiated	initiate	VERB
admet-830	93	4	by	by	ADP
admet-830	93	5	the	the	DET
admet-830	93	6	addition	addition	NOUN
admet-830	93	7	of	of	ADP
admet-830	93	8	2	2	NUM
admet-830	93	9	ml	ml	NOUN
admet-830	93	10	of	of	ADP
admet-830	93	11	pancreatic	pancreatic	ADJ
admet-830	93	12	lipase	lipase	NOUN
admet-830	93	13	(	(	PUNCT
admet-830	93	14	1000	1000	NUM
admet-830	93	15	tbu	tbu	NOUN
admet-830	93	16	)	)	PUNCT
admet-830	93	17	.	.	PUNCT
admet-830	94	1	fatty	fatty	NOUN
admet-830	94	2	acids	acid	NOUN
admet-830	94	3	produced	produce	VERB
admet-830	94	4	during	during	ADP
admet-830	94	5	lipolysis	lipolysis	NOUN
admet-830	94	6	were	be	AUX
admet-830	94	7	automatically	automatically	ADV
admet-830	94	8	titrated	titrate	VERB
admet-830	94	9	with	with	ADP
admet-830	94	10	0.6	0.6	NUM
admet-830	94	11	m	m	PROPN
admet-830	94	12	naoh	naoh	NOUN
admet-830	94	13	to	to	PART
admet-830	94	14	maintain	maintain	VERB
admet-830	94	15	a	a	DET
admet-830	94	16	constant	constant	ADJ
admet-830	94	17	ph	ph	NOUN
admet-830	94	18	of	of	ADP
admet-830	94	19	6.5	6.5	NUM
admet-830	94	20	in	in	ADP
admet-830	94	21	the	the	DET
admet-830	94	22	digestion	digestion	NOUN
admet-830	94	23	medium	medium	NOUN
admet-830	94	24	.	.	PUNCT
admet-830	95	1	the	the	DET
admet-830	95	2	cumulative	cumulative	ADJ
admet-830	95	3	volume	volume	NOUN
admet-830	95	4	of	of	ADP
admet-830	95	5	naoh	naoh	NOUN
admet-830	95	6	was	be	AUX
admet-830	95	7	converted	convert	VERB
admet-830	95	8	into	into	ADP
admet-830	95	9	percentage	percentage	NOUN
admet-830	95	10	lipolysis	lipolysis	NOUN
admet-830	95	11	using	use	VERB
admet-830	95	12	equation	equation	NOUN
admet-830	95	13	1	1	NUM
admet-830	95	14	,	,	PUNCT
admet-830	95	15	where	where	SCONJ
admet-830	95	16	v	v	NOUN
admet-830	95	17	is	be	AUX
admet-830	95	18	volume	volume	NOUN
admet-830	95	19	,	,	PUNCT
admet-830	95	20	c	c	PROPN
admet-830	95	21	is	be	AUX
admet-830	95	22	concentration	concentration	NOUN
admet-830	95	23	,	,	PUNCT
admet-830	95	24	mw	mw	X
admet-830	95	25	is	be	AUX
admet-830	95	26	molecular	molecular	ADJ
admet-830	95	27	weight	weight	NOUN
admet-830	95	28	and	and	CCONJ
admet-830	95	29	m	m	NOUN
admet-830	95	30	is	be	AUX
admet-830	95	31	the	the	DET
admet-830	95	32	moles	mole	NOUN
admet-830	95	33	of	of	ADP
admet-830	95	34	fatty	fatty	NOUN
admet-830	95	35	acids	acid	NOUN
admet-830	95	36	produced	produce	VERB
admet-830	95	37	.	.	PUNCT
admet-830	96	1	lipolysis	lipolysis	NOUN
admet-830	96	2	(	(	PUNCT
admet-830	96	3	%	%	INTJ
admet-830	96	4	)	)	PUNCT
admet-830	96	5	=	=	PUNCT
admet-830	97	1	𝑉𝑁𝑎𝑂𝐻	𝑉𝑁𝑎𝑂𝐻	PROPN
admet-830	97	2	×	×	NOUN
admet-830	97	3	𝐶𝑁𝑎𝑂𝐻	𝐶𝑁𝑎𝑂𝐻	PROPN
admet-830	97	4	𝑀𝑊𝑙𝑖𝑝𝑖𝑑×	𝑀𝑊𝑙𝑖𝑝𝑖𝑑×	PROPN
admet-830	97	5	𝑚𝐹𝑎𝑡𝑡𝑦	𝑚𝐹𝑎𝑡𝑡𝑦	PROPN
admet-830	97	6	𝑎𝑐𝑖𝑑	𝑎𝑐𝑖𝑑	NOUN
admet-830	97	7	(	(	PUNCT
admet-830	97	8	1	1	NUM
admet-830	97	9	)	)	PUNCT
admet-830	97	10	to	to	PART
admet-830	97	11	monitor	monitor	VERB
admet-830	97	12	drug	drug	NOUN
admet-830	97	13	solubilisation	solubilisation	NOUN
admet-830	97	14	,	,	PUNCT
admet-830	97	15	aliquots	aliquot	NOUN
admet-830	97	16	were	be	AUX
admet-830	97	17	taken	take	VERB
admet-830	97	18	at	at	ADP
admet-830	97	19	pre	pre	ADJ
admet-830	97	20	-	-	ADJ
admet-830	97	21	determined	determined	ADJ
admet-830	97	22	time	time	NOUN
admet-830	97	23	points	point	VERB
admet-830	97	24	up	up	ADP
admet-830	97	25	to	to	PART
admet-830	97	26	60	60	NUM
admet-830	97	27	min	min	NOUN
admet-830	97	28	and	and	CCONJ
admet-830	97	29	added	add	VERB
admet-830	97	30	to	to	PART
admet-830	97	31	centrifuge	centrifuge	VERB
admet-830	97	32	tubes	tube	NOUN
admet-830	97	33	containing	contain	VERB
admet-830	97	34	0.5	0.5	NUM
admet-830	97	35	m	m	NOUN
admet-830	97	36	4	4	NUM
admet-830	97	37	-	-	PUNCT
admet-830	97	38	bba	bba	NOUN
admet-830	97	39	to	to	PART
admet-830	97	40	inhibit	inhibit	VERB
admet-830	97	41	lipase	lipase	NOUN
admet-830	97	42	action	action	NOUN
admet-830	97	43	.	.	PUNCT
admet-830	98	1	samples	sample	NOUN
admet-830	98	2	were	be	AUX
admet-830	98	3	centrifuged	centrifuge	VERB
admet-830	98	4	at	at	ADP
admet-830	98	5	35170	35170	NUM
admet-830	98	6	×	×	NOUN
admet-830	98	7	g	g	NOUN
admet-830	98	8	for	for	ADP
admet-830	98	9	1	1	NUM
admet-830	98	10	h	h	NOUN
admet-830	98	11	at	at	ADP
admet-830	98	12	37	37	NUM
admet-830	98	13	°	°	ADP
admet-830	98	14	c	c	NOUN
admet-830	98	15	to	to	PART
admet-830	98	16	separate	separate	VERB
admet-830	98	17	the	the	DET
admet-830	98	18	solubilised	solubilise	VERB
admet-830	98	19	aqueous	aqueous	ADJ
admet-830	98	20	phase	phase	NOUN
admet-830	98	21	and	and	CCONJ
admet-830	98	22	precipitated	precipitate	VERB
admet-830	98	23	pellet	pellet	NOUN
admet-830	98	24	phase	phase	NOUN
admet-830	98	25	.	.	PUNCT
admet-830	99	1	the	the	DET
admet-830	99	2	aqueous	aqueous	ADJ
admet-830	99	3	phase	phase	NOUN
admet-830	99	4	was	be	AUX
admet-830	99	5	then	then	ADV
admet-830	99	6	extracted	extract	VERB
admet-830	99	7	with	with	ADP
admet-830	99	8	acetonitrile	acetonitrile	NOUN
admet-830	99	9	,	,	PUNCT
admet-830	99	10	sonicated	sonicate	VERB
admet-830	99	11	for	for	ADP
admet-830	99	12	10	10	NUM
admet-830	99	13	min	min	NOUN
admet-830	99	14	and	and	CCONJ
admet-830	99	15	centrifuged	centrifuge	VERB
admet-830	99	16	again	again	ADV
admet-830	99	17	at	at	ADP
admet-830	99	18	29066	29066	NUM
admet-830	99	19	×	×	NOUN
admet-830	99	20	g	g	NOUN
admet-830	99	21	for	for	ADP
admet-830	99	22	10	10	NUM
admet-830	99	23	min	min	NOUN
admet-830	99	24	at	at	ADP
admet-830	99	25	24	24	NUM
admet-830	99	26	°	°	NOUN
admet-830	99	27	c	c	NOUN
admet-830	99	28	.	.	PUNCT
admet-830	100	1	samples	sample	NOUN
admet-830	100	2	were	be	AUX
admet-830	100	3	diluted	dilute	VERB
admet-830	100	4	appropriately	appropriately	ADV
admet-830	100	5	for	for	ADP
admet-830	100	6	analysis	analysis	NOUN
admet-830	100	7	via	via	ADP
admet-830	100	8	hplc	hplc	NOUN
admet-830	100	9	and	and	CCONJ
admet-830	100	10	lcms	lcms	PROPN
admet-830	100	11	for	for	ADP
admet-830	100	12	ris	ris	PROPN
admet-830	100	13	and	and	CCONJ
admet-830	100	14	lur	lur	PROPN
admet-830	100	15	,	,	PUNCT
admet-830	100	16	respectively	respectively	ADV
admet-830	100	17	.	.	PUNCT
admet-830	101	1	zeta	zeta	PROPN
admet-830	101	2	potential	potential	ADJ
admet-830	101	3	measurements	measurement	NOUN
admet-830	101	4	of	of	ADP
admet-830	101	5	silica	silica	NOUN
admet-830	101	6	:	:	PUNCT
admet-830	101	7	drug	drug	NOUN
admet-830	101	8	:	:	PUNCT
admet-830	101	9	fatty	fatty	NOUN
admet-830	101	10	acid	acid	NOUN
admet-830	101	11	complexes	complex	NOUN
admet-830	101	12	zeta	zeta	NOUN
admet-830	101	13	potential	potential	ADJ
admet-830	101	14	measurements	measurement	NOUN
admet-830	101	15	were	be	AUX
admet-830	101	16	performed	perform	VERB
admet-830	101	17	using	use	VERB
admet-830	101	18	phase	phase	NOUN
admet-830	101	19	analysis	analysis	NOUN
admet-830	101	20	light	light	ADJ
admet-830	101	21	scattering	scattering	NOUN
admet-830	101	22	(	(	PUNCT
admet-830	101	23	pals	pal	NOUN
admet-830	101	24	;	;	PUNCT
admet-830	101	25	zetasizer	zetasizer	X
admet-830	101	26	nano	nano	PROPN
admet-830	101	27	zs	zs	PROPN
admet-830	101	28	,	,	PUNCT
admet-830	101	29	malvern	malvern	PROPN
admet-830	101	30	instruments	instrument	NOUN
admet-830	101	31	,	,	PUNCT
admet-830	101	32	worcestershire	worcestershire	NOUN
admet-830	101	33	,	,	PUNCT
admet-830	101	34	uk	uk	PROPN
admet-830	101	35	)	)	PUNCT
admet-830	101	36	,	,	PUNCT
admet-830	101	37	to	to	PART
admet-830	101	38	investigate	investigate	VERB
admet-830	101	39	possible	possible	ADJ
admet-830	101	40	interactions	interaction	NOUN
admet-830	101	41	between	between	ADP
admet-830	101	42	the	the	DET
admet-830	101	43	porous	porous	ADJ
admet-830	101	44	silica	silica	NOUN
admet-830	101	45	particles	particle	NOUN
admet-830	101	46	,	,	PUNCT
admet-830	101	47	drug	drug	NOUN
admet-830	101	48	molecules	molecule	NOUN
admet-830	101	49	and	and	CCONJ
admet-830	101	50	fatty	fatty	NOUN
admet-830	101	51	acids	acid	NOUN
admet-830	101	52	.	.	PUNCT
admet-830	102	1	firstly	firstly	ADV
admet-830	102	2	,	,	PUNCT
admet-830	102	3	the	the	DET
admet-830	102	4	zeta	zeta	NOUN
admet-830	102	5	potential	potential	NOUN
admet-830	102	6	of	of	ADP
admet-830	102	7	spray	spray	NOUN
admet-830	102	8	dried	dry	VERB
admet-830	102	9	fumed	fume	VERB
admet-830	102	10	silica	silica	NOUN
admet-830	102	11	particles	particle	NOUN
admet-830	102	12	,	,	PUNCT
admet-830	102	13	dispersed	disperse	VERB
admet-830	102	14	in	in	ADP
admet-830	102	15	lipolysis	lipolysis	NOUN
admet-830	102	16	media	medium	NOUN
admet-830	102	17	at	at	ADP
admet-830	102	18	a	a	DET
admet-830	102	19	concentration	concentration	NOUN
admet-830	102	20	of	of	ADP
admet-830	102	21	50	50	NUM
admet-830	102	22	µg	µg	NOUN
admet-830	102	23	/	/	SYM
admet-830	102	24	ml	ml	NOUN
admet-830	102	25	,	,	PUNCT
admet-830	102	26	was	be	AUX
admet-830	102	27	assessed	assess	VERB
admet-830	102	28	.	.	PUNCT
admet-830	103	1	then	then	ADV
admet-830	103	2	,	,	PUNCT
admet-830	103	3	drug	drug	NOUN
admet-830	103	4	dissolved	dissolve	VERB
admet-830	103	5	in	in	ADP
admet-830	103	6	50	50	NUM
admet-830	103	7	:	:	SYM
admet-830	103	8	50	50	NUM
admet-830	103	9	methanol	methanol	NOUN
admet-830	103	10	:	:	PUNCT
admet-830	103	11	water	water	NOUN
admet-830	103	12	mix	mix	NOUN
admet-830	103	13	was	be	AUX
admet-830	103	14	added	add	VERB
admet-830	103	15	to	to	ADP
admet-830	103	16	this	this	DET
admet-830	103	17	dispersion	dispersion	NOUN
admet-830	103	18	at	at	ADP
admet-830	103	19	a	a	DET
admet-830	103	20	final	final	ADJ
admet-830	103	21	concentration	concentration	NOUN
admet-830	103	22	of	of	ADP
admet-830	103	23	5	5	NUM
admet-830	103	24	µg	µg	NOUN
admet-830	103	25	/	/	SYM
admet-830	103	26	ml	ml	NOUN
admet-830	103	27	and	and	CCONJ
admet-830	103	28	the	the	DET
admet-830	103	29	zeta	zeta	NOUN
admet-830	103	30	potential	potential	NOUN
admet-830	103	31	was	be	AUX
admet-830	103	32	reanalysed	reanalyse	VERB
admet-830	103	33	.	.	PUNCT
admet-830	104	1	finally	finally	ADV
admet-830	104	2	,	,	PUNCT
admet-830	104	3	the	the	DET
admet-830	104	4	silica	silica	NOUN
admet-830	104	5	:	:	PUNCT
admet-830	104	6	drug	drug	NOUN
admet-830	104	7	complex	complex	NOUN
admet-830	104	8	was	be	AUX
admet-830	104	9	spiked	spike	VERB
admet-830	104	10	with	with	ADP
admet-830	104	11	myristic	myristic	ADJ
admet-830	104	12	acid	acid	NOUN
admet-830	104	13	(	(	PUNCT
admet-830	104	14	medium	medium	NOUN
admet-830	104	15	chain	chain	NOUN
admet-830	104	16	,	,	PUNCT
admet-830	104	17	c12	c12	PROPN
admet-830	104	18	fatty	fatty	NOUN
admet-830	104	19	acid	acid	NOUN
admet-830	104	20	;	;	PUNCT
admet-830	104	21	50	50	NUM
admet-830	104	22	µg	µg	NOUN
admet-830	104	23	/	/	SYM
admet-830	104	24	ml	ml	NOUN
admet-830	104	25	)	)	PUNCT
admet-830	104	26	and	and	CCONJ
admet-830	104	27	the	the	DET
admet-830	104	28	zeta	zeta	PROPN
admet-830	104	29	potential	potential	NOUN
admet-830	104	30	was	be	AUX
admet-830	104	31	again	again	ADV
admet-830	104	32	reanalysed	reanalyse	VERB
admet-830	104	33	.	.	PUNCT
admet-830	105	1	zeta	zeta	PROPN
admet-830	105	2	potential	potential	ADJ
admet-830	105	3	measurements	measurement	NOUN
admet-830	105	4	are	be	AUX
admet-830	105	5	presented	present	VERB
admet-830	105	6	as	as	ADP
admet-830	105	7	mean	mean	NOUN
admet-830	105	8	±	±	NUM
admet-830	105	9	standard	standard	ADJ
admet-830	105	10	deviation	deviation	NOUN
admet-830	105	11	of	of	ADP
admet-830	105	12	3	3	NUM
admet-830	105	13	replicate	replicate	ADJ
admet-830	105	14	measurements	measurement	NOUN
admet-830	105	15	.	.	PUNCT
admet-830	106	1	statistical	statistical	ADJ
admet-830	106	2	analysis	analysis	NOUN
admet-830	106	3	experimental	experimental	ADJ
admet-830	106	4	data	datum	NOUN
admet-830	106	5	were	be	AUX
admet-830	106	6	statistically	statistically	ADV
admet-830	106	7	analysed	analyse	VERB
admet-830	106	8	using	use	VERB
admet-830	106	9	an	an	DET
admet-830	106	10	unpaired	unpaired	ADJ
admet-830	106	11	student	student	NOUN
admet-830	106	12	’s	’s	PART
admet-830	106	13	t	t	PROPN
admet-830	106	14	-	-	PUNCT
admet-830	106	15	test	test	NOUN
admet-830	106	16	in	in	ADP
admet-830	106	17	graphpad	graphpad	PROPN
admet-830	106	18	.	.	PUNCT
admet-830	107	1	data	datum	NOUN
admet-830	107	2	was	be	AUX
admet-830	107	3	considered	consider	VERB
admet-830	107	4	statistically	statistically	ADJ
admet-830	107	5	significance	significance	NOUN
admet-830	107	6	when	when	SCONJ
admet-830	107	7	p	p	X
admet-830	107	8	<	<	X
admet-830	107	9	0.05	0.05	NUM
admet-830	107	10	.	.	PUNCT
admet-830	108	1	results	result	NOUN
admet-830	108	2	and	and	CCONJ
admet-830	108	3	discussion	discussion	NOUN
admet-830	108	4	fabrication	fabrication	NOUN
admet-830	108	5	and	and	CCONJ
admet-830	108	6	physicochemical	physicochemical	ADJ
admet-830	108	7	characterisation	characterisation	NOUN
admet-830	108	8	of	of	ADP
admet-830	108	9	ris	ris	PROPN
admet-830	108	10	and	and	CCONJ
admet-830	108	11	lur	lur	PROPN
admet-830	108	12	formulations	formulation	NOUN
admet-830	108	13	the	the	DET
admet-830	108	14	drug	drug	NOUN
admet-830	108	15	loading	loading	NOUN
admet-830	108	16	levels	level	NOUN
admet-830	108	17	of	of	ADP
admet-830	108	18	lbfs	lbfs	NOUN
admet-830	108	19	is	be	AUX
admet-830	108	20	dependent	dependent	ADJ
admet-830	108	21	on	on	ADP
admet-830	108	22	the	the	DET
admet-830	108	23	solubilising	solubilise	VERB
admet-830	108	24	capacity	capacity	NOUN
admet-830	108	25	of	of	ADP
admet-830	108	26	the	the	DET
admet-830	108	27	active	active	ADJ
admet-830	108	28	pharmaceutical	pharmaceutical	ADJ
admet-830	108	29	ingredient	ingredient	NOUN
admet-830	108	30	in	in	ADP
admet-830	108	31	the	the	DET
admet-830	108	32	lipid	lipid	NOUN
admet-830	108	33	reservoir	reservoir	NOUN
admet-830	108	34	.	.	PUNCT
admet-830	109	1	therefore	therefore	ADV
admet-830	109	2	,	,	PUNCT
admet-830	109	3	the	the	DET
admet-830	109	4	equilibrium	equilibrium	NOUN
admet-830	109	5	solubilities	solubility	NOUN
admet-830	109	6	(	(	PUNCT
admet-830	109	7	seq	seq	NOUN
admet-830	109	8	)	)	PUNCT
admet-830	109	9	of	of	ADP
admet-830	109	10	lur	lur	PROPN
admet-830	109	11	and	and	CCONJ
admet-830	109	12	ris	ris	PROPN
admet-830	109	13	,	,	PUNCT
admet-830	109	14	at	at	ADP
admet-830	109	15	room	room	NOUN
admet-830	109	16	temperature	temperature	NOUN
admet-830	109	17	,	,	PUNCT
admet-830	109	18	were	be	AUX
admet-830	109	19	investigated	investigate	VERB
admet-830	109	20	in	in	ADP
admet-830	109	21	miglyol	miglyol	NOUN
admet-830	109	22	®	®	NOUN
admet-830	109	23	812	812	NUM
admet-830	109	24	,	,	PUNCT
admet-830	109	25	capmul	capmul	PROPN
admet-830	109	26	®	®	PROPN
admet-830	109	27	mcm	mcm	PROPN
admet-830	109	28	and	and	CCONJ
admet-830	109	29	soybean	soybean	NOUN
admet-830	109	30	oil	oil	NOUN
admet-830	109	31	,	,	PUNCT
admet-830	109	32	since	since	SCONJ
admet-830	109	33	each	each	DET
admet-830	109	34	lipid	lipid	NOUN
admet-830	109	35	comprises	comprise	NOUN
admet-830	109	36	of	of	ADP
admet-830	109	37	varying	vary	VERB
admet-830	109	38	chain	chain	NOUN
admet-830	109	39	lengths	length	NOUN
admet-830	109	40	and	and	CCONJ
admet-830	109	41	compositions	composition	NOUN
admet-830	109	42	(	(	PUNCT
admet-830	109	43	figure	figure	NOUN
admet-830	109	44	1	1	NUM
admet-830	109	45	)	)	PUNCT
admet-830	109	46	.	.	PUNCT
admet-830	110	1	capmul	capmul	PROPN
admet-830	110	2	®	®	PROPN
admet-830	110	3	mcm	mcm	PROPN
admet-830	110	4	,	,	PUNCT
admet-830	110	5	a	a	DET
admet-830	110	6	mixture	mixture	NOUN
admet-830	110	7	of	of	ADP
admet-830	110	8	medium	medium	ADJ
admet-830	110	9	chain	chain	NOUN
admet-830	110	10	monoand	monoand	NOUN
admet-830	110	11	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	110	12	admet	admet	PROPN
admet-830	110	13	&	&	CCONJ
admet-830	110	14	dmpk	dmpk	PROPN
admet-830	110	15	8(4	8(4	NOUN
admet-830	110	16	)	)	PUNCT
admet-830	110	17	(	(	PUNCT
admet-830	110	18	2020	2020	NUM
admet-830	110	19	)	)	PUNCT
admet-830	110	20	437	437	NUM
admet-830	110	21	-	-	SYM
admet-830	110	22	451	451	NUM
admet-830	110	23	drug	drug	NOUN
admet-830	110	24	ionisation	ionisation	NOUN
admet-830	110	25	and	and	CCONJ
admet-830	110	26	lipid	lipid	NOUN
admet-830	110	27	-	-	PUNCT
admet-830	110	28	based	base	VERB
admet-830	110	29	formulations	formulation	NOUN
admet-830	110	30	doi	doi	NOUN
admet-830	110	31	:	:	PUNCT
admet-830	110	32	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	110	33	442	442	NUM
admet-830	110	34	di	di	NOUN
admet-830	110	35	-	-	PUNCT
admet-830	110	36	glyceride	glyceride	ADJ
admet-830	110	37	medium	medium	NOUN
admet-830	110	38	chain	chain	NOUN
admet-830	110	39	fatty	fatty	NOUN
admet-830	110	40	acids	acid	NOUN
admet-830	110	41	,	,	PUNCT
admet-830	110	42	provided	provide	VERB
admet-830	110	43	the	the	DET
admet-830	110	44	highest	high	ADJ
admet-830	110	45	solubilisation	solubilisation	NOUN
admet-830	110	46	for	for	ADP
admet-830	110	47	both	both	DET
admet-830	110	48	compounds	compound	NOUN
admet-830	110	49	,	,	PUNCT
admet-830	110	50	reaching	reach	VERB
admet-830	110	51	a	a	DET
admet-830	110	52	solubilisation	solubilisation	NOUN
admet-830	110	53	capacity	capacity	NOUN
admet-830	110	54	of	of	ADP
admet-830	110	55	39.7	39.7	NUM
admet-830	110	56	±	±	NUM
admet-830	110	57	2.8	2.8	NUM
admet-830	110	58	mg	mg	PROPN
admet-830	110	59	/	/	SYM
admet-830	110	60	g	g	NOUN
admet-830	110	61	and	and	CCONJ
admet-830	110	62	14.0	14.0	NUM
admet-830	110	63	±	±	NUM
admet-830	110	64	0.6	0.6	NUM
admet-830	110	65	mg	mg	PROPN
admet-830	110	66	/	/	SYM
admet-830	110	67	g	g	NOUN
admet-830	110	68	for	for	ADP
admet-830	110	69	ris	ris	PROPN
admet-830	110	70	and	and	CCONJ
admet-830	110	71	lur	lur	PROPN
admet-830	110	72	,	,	PUNCT
admet-830	110	73	respectively	respectively	ADV
admet-830	110	74	.	.	PUNCT
admet-830	111	1	miglyol	miglyol	NOUN
admet-830	111	2	®	®	NOUN
admet-830	111	3	812	812	NUM
admet-830	111	4	,	,	PUNCT
admet-830	111	5	a	a	DET
admet-830	111	6	mixture	mixture	NOUN
admet-830	111	7	of	of	ADP
admet-830	111	8	medium	medium	ADJ
admet-830	111	9	chain	chain	NOUN
admet-830	111	10	triglycerides	triglyceride	NOUN
admet-830	111	11	,	,	PUNCT
admet-830	111	12	revealed	reveal	VERB
admet-830	111	13	a	a	DET
admet-830	111	14	higher	high	ADJ
admet-830	111	15	solubilisation	solubilisation	NOUN
admet-830	111	16	for	for	ADP
admet-830	111	17	lur	lur	PROPN
admet-830	111	18	,	,	PUNCT
admet-830	111	19	reaching	reach	VERB
admet-830	111	20	a	a	DET
admet-830	111	21	seq	seq	NOUN
admet-830	111	22	of	of	ADP
admet-830	111	23	12.8	12.8	NUM
admet-830	111	24	±	±	NUM
admet-830	111	25	0.3	0.3	NUM
admet-830	111	26	mg	mg	PROPN
admet-830	111	27	/	/	SYM
admet-830	111	28	g	g	NOUN
admet-830	111	29	,	,	PUNCT
admet-830	111	30	compared	compare	VERB
admet-830	111	31	to	to	ADP
admet-830	111	32	3.13	3.13	NUM
admet-830	111	33	±	±	NUM
admet-830	111	34	0.1	0.1	NUM
admet-830	111	35	mg	mg	PROPN
admet-830	111	36	/	/	SYM
admet-830	111	37	g	g	NOUN
admet-830	111	38	for	for	ADP
admet-830	111	39	ris	ris	PROPN
admet-830	111	40	.	.	PUNCT
admet-830	112	1	no	no	DET
admet-830	112	2	significant	significant	ADJ
admet-830	112	3	difference	difference	NOUN
admet-830	112	4	was	be	AUX
admet-830	112	5	found	find	VERB
admet-830	112	6	between	between	ADP
admet-830	112	7	ris	ris	PROPN
admet-830	112	8	and	and	CCONJ
admet-830	112	9	lur	lur	PROPN
admet-830	112	10	in	in	ADP
admet-830	112	11	soybean	soybean	NOUN
admet-830	112	12	oil	oil	NOUN
admet-830	112	13	,	,	PUNCT
admet-830	112	14	which	which	PRON
admet-830	112	15	is	be	AUX
admet-830	112	16	a	a	DET
admet-830	112	17	mixture	mixture	NOUN
admet-830	112	18	of	of	ADP
admet-830	112	19	long	long	ADJ
admet-830	112	20	chain	chain	NOUN
admet-830	112	21	triglycerides	triglyceride	NOUN
admet-830	112	22	(	(	PUNCT
admet-830	112	23	8.53	8.53	NUM
admet-830	112	24	±	±	NUM
admet-830	112	25	0.2	0.2	NUM
admet-830	112	26	mg	mg	PROPN
admet-830	112	27	/	/	SYM
admet-830	112	28	g	g	NOUN
admet-830	112	29	for	for	ADP
admet-830	112	30	ris	ris	PROPN
admet-830	112	31	and	and	CCONJ
admet-830	112	32	7.99	7.99	NUM
admet-830	112	33	±	±	NUM
admet-830	112	34	0.6	0.6	NUM
admet-830	112	35	mg	mg	PROPN
admet-830	112	36	/	/	SYM
admet-830	112	37	g	g	NOUN
admet-830	112	38	for	for	ADP
admet-830	112	39	lur	lur	PROPN
admet-830	112	40	)	)	PUNCT
admet-830	112	41	.	.	PUNCT
admet-830	113	1	therefore	therefore	ADV
admet-830	113	2	,	,	PUNCT
admet-830	113	3	capmul	capmul	PROPN
admet-830	113	4	®	®	PROPN
admet-830	113	5	mcm	mcm	PROPN
admet-830	113	6	was	be	AUX
admet-830	113	7	chosen	choose	VERB
admet-830	113	8	for	for	ADP
admet-830	113	9	further	further	ADJ
admet-830	113	10	formulation	formulation	NOUN
admet-830	113	11	development	development	NOUN
admet-830	113	12	since	since	SCONJ
admet-830	113	13	it	it	PRON
admet-830	113	14	provided	provide	VERB
admet-830	113	15	the	the	DET
admet-830	113	16	highest	high	ADJ
admet-830	113	17	solubilisation	solubilisation	NOUN
admet-830	113	18	capacity	capacity	NOUN
admet-830	113	19	for	for	ADP
admet-830	113	20	both	both	DET
admet-830	113	21	ris	ris	PROPN
admet-830	113	22	and	and	CCONJ
admet-830	113	23	lur	lur	PROPN
admet-830	113	24	and	and	CCONJ
admet-830	113	25	allows	allow	VERB
admet-830	113	26	for	for	ADP
admet-830	113	27	the	the	DET
admet-830	113	28	highest	high	ADJ
admet-830	113	29	drug	drug	NOUN
admet-830	113	30	loading	loading	NOUN
admet-830	113	31	levels	level	NOUN
admet-830	113	32	within	within	ADP
admet-830	113	33	each	each	DET
admet-830	113	34	lbf	lbf	PROPN
admet-830	113	35	.	.	PROPN
admet-830	113	36	figure	figure	NOUN
admet-830	113	37	1	1	NUM
admet-830	113	38	.	.	PUNCT
admet-830	114	1	equilibrium	equilibrium	NOUN
admet-830	114	2	solubilities	solubility	NOUN
admet-830	114	3	of	of	ADP
admet-830	114	4	ris	ris	PROPN
admet-830	114	5	and	and	CCONJ
admet-830	114	6	lur	lur	PROPN
admet-830	114	7	in	in	ADP
admet-830	114	8	various	various	ADJ
admet-830	114	9	lipids	lipid	NOUN
admet-830	114	10	.	.	PUNCT
admet-830	115	1	each	each	DET
admet-830	115	2	value	value	NOUN
admet-830	115	3	represents	represent	VERB
admet-830	115	4	the	the	DET
admet-830	115	5	mean	mean	ADJ
admet-830	115	6	±	±	NUM
admet-830	115	7	sd	sd	NOUN
admet-830	115	8	,	,	PUNCT
admet-830	115	9	n	n	NOUN
admet-830	115	10	=	=	SYM
admet-830	115	11	3	3	X
admet-830	115	12	.	.	PUNCT
admet-830	116	1	the	the	DET
admet-830	116	2	clinical	clinical	ADJ
admet-830	116	3	oral	oral	ADJ
admet-830	116	4	daily	daily	ADJ
admet-830	116	5	dose	dose	NOUN
admet-830	116	6	of	of	ADP
admet-830	116	7	lur	lur	PROPN
admet-830	116	8	ranges	range	VERB
admet-830	116	9	from	from	ADP
admet-830	116	10	20	20	NUM
admet-830	116	11	–	–	PUNCT
admet-830	116	12	160	160	NUM
admet-830	116	13	mg	mg	NUM
admet-830	116	14	/	/	SYM
admet-830	116	15	day	day	NOUN
admet-830	116	16	,	,	PUNCT
admet-830	116	17	compared	compare	VERB
admet-830	116	18	to	to	ADP
admet-830	116	19	2	2	NUM
admet-830	116	20	–	–	PUNCT
admet-830	116	21	16	16	NUM
admet-830	116	22	mg	mg	NUM
admet-830	116	23	/	/	SYM
admet-830	116	24	day	day	NOUN
admet-830	116	25	for	for	ADP
admet-830	116	26	ris	ris	X
admet-830	117	1	[	[	X
admet-830	117	2	23	23	NUM
admet-830	117	3	,	,	PUNCT
admet-830	117	4	24	24	NUM
admet-830	117	5	]	]	PUNCT
admet-830	117	6	.	.	PUNCT
admet-830	118	1	consequently	consequently	ADV
admet-830	118	2	,	,	PUNCT
admet-830	118	3	due	due	ADP
admet-830	118	4	to	to	ADP
admet-830	118	5	different	different	ADJ
admet-830	118	6	dosing	dose	VERB
admet-830	118	7	requirements	requirement	NOUN
admet-830	118	8	,	,	PUNCT
admet-830	118	9	submicron	submicron	NOUN
admet-830	118	10	emulsions	emulsion	NOUN
admet-830	118	11	were	be	AUX
admet-830	118	12	fabricated	fabricate	VERB
admet-830	118	13	by	by	ADP
admet-830	118	14	dissolving	dissolve	VERB
admet-830	118	15	lur	lur	PROPN
admet-830	118	16	and	and	CCONJ
admet-830	118	17	ris	ris	PROPN
admet-830	118	18	in	in	ADP
admet-830	118	19	capmul	capmul	PROPN
admet-830	118	20	®	®	PROPN
admet-830	118	21	mcm	mcm	PROPN
admet-830	118	22	at	at	ADP
admet-830	118	23	100	100	NUM
admet-830	118	24	%	%	NOUN
admet-830	118	25	and	and	CCONJ
admet-830	118	26	80	80	NUM
admet-830	118	27	%	%	NOUN
admet-830	118	28	their	their	PRON
admet-830	118	29	seq	seq	NOUN
admet-830	118	30	,	,	PUNCT
admet-830	118	31	respectively	respectively	ADV
admet-830	118	32	.	.	PUNCT
admet-830	119	1	table	table	NOUN
admet-830	119	2	1	1	NUM
admet-830	119	3	summarises	summarise	VERB
admet-830	119	4	the	the	DET
admet-830	119	5	drug	drug	NOUN
admet-830	119	6	loading	loading	NOUN
admet-830	119	7	levels	level	NOUN
admet-830	119	8	and	and	CCONJ
admet-830	119	9	loading	loading	NOUN
admet-830	119	10	efficiencies	efficiency	NOUN
admet-830	119	11	of	of	ADP
admet-830	119	12	the	the	DET
admet-830	119	13	investigated	investigate	VERB
admet-830	119	14	formulations	formulation	NOUN
admet-830	119	15	.	.	PUNCT
admet-830	120	1	the	the	DET
admet-830	120	2	submicron	submicron	NOUN
admet-830	120	3	emulsions	emulsion	NOUN
admet-830	120	4	for	for	ADP
admet-830	120	5	lur	lur	PROPN
admet-830	120	6	and	and	CCONJ
admet-830	120	7	ris	ris	PROPN
admet-830	120	8	will	will	AUX
admet-830	120	9	be	be	AUX
admet-830	120	10	referred	refer	VERB
admet-830	120	11	to	to	ADP
admet-830	120	12	as	as	ADP
admet-830	120	13	lur	lur	NOUN
admet-830	120	14	emulsion	emulsion	NOUN
admet-830	120	15	and	and	CCONJ
admet-830	120	16	ris	ris	PROPN
admet-830	120	17	emulsion	emulsion	NOUN
admet-830	120	18	,	,	PUNCT
admet-830	120	19	respectively	respectively	ADV
admet-830	120	20	,	,	PUNCT
admet-830	120	21	herein	herein	NOUN
admet-830	120	22	.	.	PUNCT
admet-830	121	1	the	the	DET
admet-830	121	2	drug	drug	NOUN
admet-830	121	3	loading	loading	NOUN
admet-830	121	4	level	level	NOUN
admet-830	121	5	of	of	ADP
admet-830	121	6	the	the	DET
admet-830	121	7	ris	ris	PROPN
admet-830	121	8	emulsion	emulsion	NOUN
admet-830	121	9	was	be	AUX
admet-830	121	10	3.12	3.12	NUM
admet-830	121	11	±	±	NUM
admet-830	121	12	0.0	0.0	NUM
admet-830	121	13	%	%	NOUN
admet-830	121	14	w	w	PROPN
admet-830	121	15	/	/	SYM
admet-830	121	16	w	w	PROPN
admet-830	121	17	,	,	PUNCT
admet-830	121	18	compared	compare	VERB
admet-830	121	19	to	to	ADP
admet-830	121	20	1.4	1.4	NUM
admet-830	121	21	±	±	NUM
admet-830	121	22	0.0	0.0	NUM
admet-830	121	23	%	%	NOUN
admet-830	121	24	w	w	PROPN
admet-830	121	25	/	/	SYM
admet-830	121	26	w	w	NOUN
admet-830	121	27	for	for	ADP
admet-830	121	28	the	the	DET
admet-830	121	29	lur	lur	PROPN
admet-830	121	30	emulsion	emulsion	NOUN
admet-830	121	31	.	.	PUNCT
admet-830	122	1	table	table	NOUN
admet-830	122	2	1	1	NUM
admet-830	122	3	.	.	PUNCT
admet-830	123	1	formulation	formulation	NOUN
admet-830	123	2	drug	drug	NOUN
admet-830	123	3	loading	loading	NOUN
admet-830	123	4	levels	level	NOUN
admet-830	123	5	and	and	CCONJ
admet-830	123	6	encapsulation	encapsulation	NOUN
admet-830	123	7	efficiencies	efficiency	NOUN
admet-830	123	8	(	(	PUNCT
admet-830	123	9	each	each	DET
admet-830	123	10	value	value	NOUN
admet-830	123	11	represents	represent	VERB
admet-830	123	12	the	the	DET
admet-830	123	13	mean	mean	ADJ
admet-830	123	14	±	±	NUM
admet-830	123	15	sd	sd	NOUN
admet-830	123	16	,	,	PUNCT
admet-830	123	17	n	n	NOUN
admet-830	123	18	=	=	SYM
admet-830	123	19	3	3	NUM
admet-830	123	20	)	)	PUNCT
admet-830	123	21	.	.	PUNCT
admet-830	124	1	slh	slh	PROPN
admet-830	124	2	formulations	formulation	NOUN
admet-830	124	3	were	be	AUX
admet-830	124	4	manufactured	manufacture	VERB
admet-830	124	5	by	by	ADP
admet-830	124	6	spray	spray	NOUN
admet-830	124	7	-	-	PUNCT
admet-830	124	8	drying	dry	VERB
admet-830	124	9	the	the	DET
admet-830	124	10	submicron	submicron	NOUN
admet-830	124	11	emulsion	emulsion	NOUN
admet-830	124	12	with	with	ADP
admet-830	124	13	a	a	DET
admet-830	124	14	silica	silica	NOUN
admet-830	124	15	nanoparticle	nanoparticle	NOUN
admet-830	124	16	dispersion	dispersion	NOUN
admet-830	124	17	to	to	PART
admet-830	124	18	form	form	VERB
admet-830	124	19	solid	solid	ADJ
admet-830	124	20	slh	slh	ADJ
admet-830	124	21	microparticles	microparticle	NOUN
admet-830	124	22	.	.	PUNCT
admet-830	125	1	ris	ris	PROPN
admet-830	125	2	-	-	ADJ
admet-830	125	3	slh	slh	ADJ
admet-830	125	4	particles	particle	NOUN
admet-830	125	5	comprised	comprise	VERB
admet-830	125	6	of	of	ADP
admet-830	125	7	a	a	DET
admet-830	125	8	1	1	NUM
admet-830	125	9	:	:	SYM
admet-830	125	10	1	1	NUM
admet-830	125	11	lipid	lipid	NOUN
admet-830	125	12	:	:	PUNCT
admet-830	125	13	silica	silica	NOUN
admet-830	125	14	ratio	ratio	NOUN
admet-830	125	15	and	and	CCONJ
admet-830	125	16	obtained	obtain	VERB
admet-830	125	17	a	a	DET
admet-830	125	18	final	final	ADJ
admet-830	125	19	drug	drug	NOUN
admet-830	125	20	load	load	NOUN
admet-830	125	21	of	of	ADP
admet-830	125	22	1.64	1.64	NUM
admet-830	125	23	±	±	NUM
admet-830	125	24	0.2	0.2	NUM
admet-830	125	25	%	%	NOUN
admet-830	125	26	w	w	PROPN
admet-830	125	27	/	/	SYM
admet-830	125	28	w.	w.	NOUN
admet-830	125	29	in	in	ADP
admet-830	125	30	attempt	attempt	NOUN
admet-830	125	31	to	to	PART
admet-830	125	32	increase	increase	VERB
admet-830	125	33	the	the	DET
admet-830	125	34	formulation	formulation	NOUN
admet-830	125	35	drug	drug	NOUN
admet-830	125	36	load	load	NOUN
admet-830	125	37	of	of	ADP
admet-830	125	38	lur	lur	PROPN
admet-830	125	39	-	-	PUNCT
admet-830	125	40	slh	slh	NOUN
admet-830	125	41	to	to	PART
admet-830	125	42	meet	meet	VERB
admet-830	125	43	the	the	DET
admet-830	125	44	higher	high	ADJ
admet-830	125	45	dosing	dosing	ADJ
admet-830	125	46	requirements	requirement	NOUN
admet-830	125	47	,	,	PUNCT
admet-830	125	48	a	a	DET
admet-830	125	49	2:1	2:1	NUM
admet-830	125	50	ratio	ratio	NOUN
admet-830	125	51	of	of	ADP
admet-830	125	52	lipid	lipid	NOUN
admet-830	125	53	:	:	PUNCT
admet-830	125	54	silica	silica	NOUN
admet-830	125	55	was	be	AUX
admet-830	125	56	utilised	utilise	VERB
admet-830	125	57	,	,	PUNCT
admet-830	125	58	achieving	achieve	VERB
admet-830	125	59	a	a	DET
admet-830	125	60	final	final	ADJ
admet-830	125	61	drug	drug	NOUN
admet-830	125	62	loading	loading	NOUN
admet-830	125	63	level	level	NOUN
admet-830	125	64	of	of	ADP
admet-830	125	65	0.75	0.75	NUM
admet-830	125	66	%	%	NOUN
admet-830	125	67	w	w	PROPN
admet-830	125	68	/	/	SYM
admet-830	125	69	w.	w.	PROPN
admet-830	125	70	both	both	DET
admet-830	125	71	slh	slh	PROPN
admet-830	125	72	formulations	formulation	NOUN
admet-830	125	73	formed	form	VERB
admet-830	125	74	free	free	ADJ
admet-830	125	75	-	-	PUNCT
admet-830	125	76	flowing	flow	VERB
admet-830	125	77	powders	powder	NOUN
admet-830	125	78	following	follow	VERB
admet-830	125	79	the	the	DET
admet-830	125	80	spray	spray	NOUN
admet-830	125	81	drying	dry	VERB
admet-830	125	82	procedure	procedure	NOUN
admet-830	125	83	.	.	PUNCT
admet-830	126	1	particle	particle	NOUN
admet-830	126	2	size	size	NOUN
admet-830	126	3	analysis	analysis	NOUN
admet-830	126	4	after	after	ADP
admet-830	126	5	a	a	DET
admet-830	126	6	5	5	NUM
admet-830	126	7	min	min	NOUN
admet-830	126	8	dispersion	dispersion	NOUN
admet-830	126	9	period	period	NOUN
admet-830	126	10	in	in	ADP
admet-830	126	11	aqueous	aqueous	ADJ
admet-830	126	12	media	medium	NOUN
admet-830	126	13	revealed	reveal	VERB
admet-830	126	14	the	the	DET
admet-830	126	15	particle	particle	NOUN
admet-830	126	16	size	size	NOUN
admet-830	126	17	of	of	ADP
admet-830	126	18	ris	ris	PROPN
admet-830	126	19	-	-	ADJ
admet-830	126	20	slh	slh	NOUN
admet-830	126	21	to	to	PART
admet-830	126	22	be	be	AUX
admet-830	126	23	slightly	slightly	ADV
admet-830	126	24	larger	large	ADJ
admet-830	126	25	than	than	ADP
admet-830	126	26	lur	lur	NOUN
admet-830	126	27	-	-	PUNCT
admet-830	126	28	slh	slh	PROPN
admet-830	126	29	(	(	PUNCT
admet-830	126	30	d[v,0.5	d[v,0.5	VERB
admet-830	126	31	]	]	PUNCT
admet-830	126	32	of	of	ADP
admet-830	126	33	9.39	9.39	NUM
admet-830	126	34	±	±	NUM
admet-830	126	35	1.3	1.3	NUM
admet-830	126	36	µm	µm	ADP
admet-830	126	37	and	and	CCONJ
admet-830	126	38	7.46	7.46	NUM
admet-830	126	39	±	±	NUM
admet-830	126	40	1.5	1.5	NUM
admet-830	126	41	µm	µm	NOUN
admet-830	126	42	for	for	ADP
admet-830	126	43	ris	ris	PROPN
admet-830	126	44	-	-	ADJ
admet-830	126	45	slh	slh	NOUN
admet-830	126	46	and	and	CCONJ
admet-830	126	47	lur	lur	PROPN
admet-830	126	48	-	-	PUNCT
admet-830	126	49	slh	slh	PROPN
admet-830	126	50	,	,	PUNCT
admet-830	126	51	respectively	respectively	ADV
admet-830	126	52	)	)	PUNCT
admet-830	126	53	.	.	PUNCT
admet-830	127	1	as	as	SCONJ
admet-830	127	2	demonstrated	demonstrate	VERB
admet-830	127	3	by	by	ADP
admet-830	127	4	the	the	DET
admet-830	127	5	sem	sem	NOUN
admet-830	127	6	images	image	NOUN
admet-830	127	7	in	in	ADP
admet-830	127	8	figure	figure	NOUN
admet-830	127	9	2	2	NUM
admet-830	127	10	,	,	PUNCT
admet-830	127	11	ris	ris	PROPN
admet-830	127	12	-	-	ADJ
admet-830	127	13	slh	slh	PROPN
admet-830	127	14	consisted	consist	VERB
admet-830	127	15	of	of	ADP
admet-830	127	16	spherical	spherical	ADJ
admet-830	127	17	porous	porous	ADJ
admet-830	127	18	microparticles	microparticle	NOUN
admet-830	127	19	,	,	PUNCT
admet-830	127	20	compared	compare	VERB
admet-830	127	21	to	to	ADP
admet-830	127	22	lur	lur	NOUN
admet-830	127	23	-	-	PUNCT
admet-830	127	24	slh	slh	PROPN
admet-830	127	25	which	which	PRON
admet-830	127	26	appeared	appear	VERB
admet-830	127	27	to	to	PART
admet-830	127	28	have	have	VERB
admet-830	127	29	a	a	DET
admet-830	127	30	collapsed	collapse	VERB
admet-830	127	31	porous	porous	ADJ
admet-830	127	32	structure	structure	NOUN
admet-830	127	33	.	.	PUNCT
admet-830	128	1	as	as	SCONJ
admet-830	128	2	the	the	DET
admet-830	128	3	spray	spray	NOUN
admet-830	128	4	-	-	PUNCT
admet-830	128	5	drying	dry	VERB
admet-830	128	6	parameters	parameter	NOUN
admet-830	128	7	were	be	AUX
admet-830	128	8	consistent	consistent	ADJ
admet-830	128	9	for	for	ADP
admet-830	128	10	both	both	DET
admet-830	128	11	formulations	formulation	NOUN
admet-830	128	12	,	,	PUNCT
admet-830	128	13	the	the	DET
admet-830	128	14	different	different	ADJ
admet-830	128	15	shape	shape	NOUN
admet-830	128	16	may	may	AUX
admet-830	128	17	be	be	AUX
admet-830	128	18	attributed	attribute	VERB
admet-830	128	19	to	to	ADP
admet-830	128	20	the	the	DET
admet-830	128	21	different	different	ADJ
admet-830	128	22	lipid	lipid	NOUN
admet-830	128	23	:	:	PUNCT
admet-830	128	24	silica	silica	NOUN
admet-830	128	25	composition	composition	NOUN
admet-830	128	26	,	,	PUNCT
admet-830	128	27	i.e.	i.e.	X
admet-830	128	28	a	a	DET
admet-830	128	29	greater	great	ADJ
admet-830	128	30	amount	amount	NOUN
admet-830	128	31	of	of	ADP
admet-830	128	32	lipid	lipid	NOUN
admet-830	128	33	resulted	result	VERB
admet-830	128	34	in	in	ADP
admet-830	128	35	the	the	DET
admet-830	128	36	collapse	collapse	NOUN
admet-830	128	37	of	of	ADP
admet-830	128	38	the	the	DET
admet-830	128	39	microparticles	microparticle	NOUN
admet-830	128	40	.	.	PUNCT
admet-830	129	1	formulation	formulation	NOUN
admet-830	129	2	drug	drug	NOUN
admet-830	129	3	loading	loading	NOUN
admet-830	129	4	(	(	PUNCT
admet-830	129	5	%	%	INTJ
admet-830	129	6	w	w	PROPN
admet-830	129	7	/	/	SYM
admet-830	129	8	w	w	NOUN
admet-830	129	9	)	)	PUNCT
admet-830	129	10	encapsulation	encapsulation	NOUN
admet-830	129	11	efficiency	efficiency	NOUN
admet-830	129	12	(	(	PUNCT
admet-830	129	13	%	%	INTJ
admet-830	129	14	)	)	PUNCT
admet-830	129	15	ris	ris	PROPN
admet-830	129	16	emulsion	emulsion	NOUN
admet-830	129	17	3.12	3.12	NUM
admet-830	129	18	±	±	NUM
admet-830	129	19	0.0	0.0	NUM
admet-830	129	20	100	100	NUM
admet-830	129	21	±	±	NUM
admet-830	129	22	0.0	0.0	NUM
admet-830	129	23	ris	ris	PROPN
admet-830	129	24	-	-	NOUN
admet-830	129	25	slh	slh	VERB
admet-830	129	26	1.64	1.64	NUM
admet-830	129	27	±	±	NUM
admet-830	129	28	0.2	0.2	NUM
admet-830	129	29	99.1	99.1	NUM
admet-830	129	30	±	±	NUM
admet-830	129	31	1.3	1.3	NUM
admet-830	129	32	lur	lur	PROPN
admet-830	129	33	emulsion	emulsion	NOUN
admet-830	129	34	1.4	1.4	NUM
admet-830	129	35	±	±	NUM
admet-830	129	36	0.0	0.0	NUM
admet-830	129	37	100	100	NUM
admet-830	129	38	±	±	NUM
admet-830	129	39	0.0	0.0	NUM
admet-830	129	40	lur	lur	PROPN
admet-830	129	41	-	-	PUNCT
admet-830	129	42	slh	slh	PROPN
admet-830	129	43	0.75	0.75	NUM
admet-830	129	44	±	±	NUM
admet-830	129	45	0.0	0.0	NUM
admet-830	129	46	81.4	81.4	NUM
admet-830	129	47	±	±	NUM
admet-830	129	48	0.0	0.0	NUM
admet-830	129	49	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	129	50	admet	admet	PROPN
admet-830	129	51	&	&	CCONJ
admet-830	129	52	dmpk	dmpk	PROPN
admet-830	129	53	8(4	8(4	NOUN
admet-830	129	54	)	)	PUNCT
admet-830	129	55	(	(	PUNCT
admet-830	129	56	2020	2020	NUM
admet-830	129	57	)	)	PUNCT
admet-830	129	58	437	437	NUM
admet-830	129	59	-	-	SYM
admet-830	129	60	451	451	NUM
admet-830	129	61	drug	drug	NOUN
admet-830	129	62	ionisation	ionisation	NOUN
admet-830	129	63	and	and	CCONJ
admet-830	129	64	lipid	lipid	NOUN
admet-830	129	65	-	-	PUNCT
admet-830	129	66	based	base	VERB
admet-830	129	67	formulations	formulation	NOUN
admet-830	129	68	doi	doi	NOUN
admet-830	129	69	:	:	PUNCT
admet-830	129	70	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	129	71	443	443	NUM
admet-830	129	72	figure	figure	NOUN
admet-830	129	73	2	2	NUM
admet-830	129	74	.	.	PUNCT
admet-830	129	75	sem	sem	NOUN
admet-830	129	76	images	image	NOUN
admet-830	129	77	depicting	depict	VERB
admet-830	129	78	the	the	DET
admet-830	129	79	surface	surface	NOUN
admet-830	129	80	morphologies	morphology	NOUN
admet-830	129	81	of	of	ADP
admet-830	129	82	(	(	PUNCT
admet-830	129	83	a	a	DET
admet-830	129	84	)	)	PUNCT
admet-830	129	85	ris	ris	PROPN
admet-830	129	86	-	-	NOUN
admet-830	129	87	slh	slh	PROPN
admet-830	129	88	,	,	PUNCT
admet-830	129	89	and	and	CCONJ
admet-830	129	90	(	(	PUNCT
admet-830	129	91	b	b	X
admet-830	129	92	)	)	PUNCT
admet-830	129	93	lur	lur	PROPN
admet-830	129	94	-	-	PUNCT
admet-830	129	95	slh	slh	NOUN
admet-830	129	96	.	.	PUNCT
admet-830	130	1	given	give	VERB
admet-830	130	2	lbfs	lbfs	NOUN
admet-830	130	3	are	be	AUX
admet-830	130	4	known	know	VERB
admet-830	130	5	for	for	ADP
admet-830	130	6	their	their	PRON
admet-830	130	7	ability	ability	NOUN
admet-830	130	8	to	to	PART
admet-830	130	9	maintain	maintain	VERB
admet-830	130	10	poorly	poorly	ADV
admet-830	130	11	water	water	NOUN
admet-830	130	12	-	-	PUNCT
admet-830	130	13	soluble	soluble	ADJ
admet-830	130	14	drugs	drug	NOUN
admet-830	130	15	in	in	ADP
admet-830	130	16	a	a	DET
admet-830	130	17	non	non	ADJ
admet-830	130	18	-	-	ADJ
admet-830	130	19	crystalline	crystalline	ADJ
admet-830	130	20	state	state	NOUN
admet-830	130	21	,	,	PUNCT
admet-830	130	22	the	the	DET
admet-830	130	23	degree	degree	NOUN
admet-830	130	24	of	of	ADP
admet-830	130	25	crystallinity	crystallinity	NOUN
admet-830	130	26	of	of	ADP
admet-830	130	27	lur	lur	PROPN
admet-830	130	28	and	and	CCONJ
admet-830	130	29	ris	ris	PROPN
admet-830	130	30	encapsulated	encapsulate	VERB
admet-830	130	31	in	in	ADP
admet-830	130	32	the	the	DET
admet-830	130	33	slh	slh	PROPN
admet-830	130	34	formulations	formulation	NOUN
admet-830	130	35	was	be	AUX
admet-830	130	36	investigated	investigate	VERB
admet-830	130	37	using	use	VERB
admet-830	130	38	dsc	dsc	NOUN
admet-830	130	39	(	(	PUNCT
admet-830	130	40	figure	figure	NOUN
admet-830	130	41	3	3	NUM
admet-830	130	42	)	)	PUNCT
admet-830	130	43	.	.	PUNCT
admet-830	131	1	the	the	DET
admet-830	131	2	thermograms	thermogram	NOUN
admet-830	131	3	of	of	ADP
admet-830	131	4	pure	pure	ADJ
admet-830	131	5	ris	ris	PROPN
admet-830	131	6	and	and	CCONJ
admet-830	131	7	lur	lur	PROPN
admet-830	131	8	powders	powder	NOUN
admet-830	131	9	displayed	display	VERB
admet-830	131	10	strong	strong	ADJ
admet-830	131	11	endothermic	endothermic	ADJ
admet-830	131	12	peaks	peak	NOUN
admet-830	131	13	at	at	ADP
admet-830	131	14	approximately	approximately	ADV
admet-830	131	15	173	173	NUM
admet-830	131	16	°	°	NOUN
admet-830	131	17	c	c	NOUN
admet-830	131	18	and	and	CCONJ
admet-830	131	19	150	150	NUM
admet-830	131	20	°	°	NOUN
admet-830	131	21	c	c	NOUN
admet-830	131	22	,	,	PUNCT
admet-830	131	23	respectively	respectively	ADV
admet-830	131	24	,	,	PUNCT
admet-830	131	25	corresponding	correspond	VERB
admet-830	131	26	to	to	ADP
admet-830	131	27	the	the	DET
admet-830	131	28	drug	drug	NOUN
admet-830	131	29	’s	’s	PART
admet-830	131	30	melting	melting	NOUN
admet-830	131	31	points	point	NOUN
admet-830	131	32	and	and	CCONJ
admet-830	131	33	thus	thus	ADV
admet-830	131	34	,	,	PUNCT
admet-830	131	35	indicating	indicate	VERB
admet-830	131	36	crystallinity	crystallinity	NOUN
admet-830	131	37	.	.	PUNCT
admet-830	132	1	due	due	ADP
admet-830	132	2	to	to	ADP
admet-830	132	3	the	the	DET
admet-830	132	4	low	low	ADJ
admet-830	132	5	drug	drug	NOUN
admet-830	132	6	loading	loading	NOUN
admet-830	132	7	levels	level	NOUN
admet-830	132	8	for	for	ADP
admet-830	132	9	slh	slh	ADJ
admet-830	132	10	formulations	formulation	NOUN
admet-830	132	11	,	,	PUNCT
admet-830	132	12	physical	physical	ADJ
admet-830	132	13	mixtures	mixture	NOUN
admet-830	132	14	containing	contain	VERB
admet-830	132	15	0.1	0.1	NUM
admet-830	132	16	%	%	NOUN
admet-830	132	17	w	w	PROPN
admet-830	132	18	/	/	SYM
admet-830	132	19	w	w	NOUN
admet-830	132	20	lur	lur	PROPN
admet-830	132	21	in	in	ADP
admet-830	132	22	silica	silica	NOUN
admet-830	132	23	and	and	CCONJ
admet-830	132	24	1	1	NUM
admet-830	132	25	%	%	NOUN
admet-830	132	26	w	w	PROPN
admet-830	132	27	/	/	SYM
admet-830	132	28	w	w	NOUN
admet-830	132	29	ris	ris	PROPN
admet-830	132	30	in	in	ADP
admet-830	132	31	silica	silica	NOUN
admet-830	132	32	were	be	AUX
admet-830	132	33	analysed	analyse	VERB
admet-830	132	34	to	to	PART
admet-830	132	35	determine	determine	VERB
admet-830	132	36	whether	whether	SCONJ
admet-830	132	37	dsc	dsc	NOUN
admet-830	132	38	provided	provide	VERB
admet-830	132	39	adequate	adequate	ADJ
admet-830	132	40	sensitivity	sensitivity	NOUN
admet-830	132	41	to	to	PART
admet-830	132	42	detect	detect	VERB
admet-830	132	43	the	the	DET
admet-830	132	44	drug	drug	NOUN
admet-830	132	45	within	within	ADP
admet-830	132	46	the	the	DET
admet-830	132	47	formulations	formulation	NOUN
admet-830	132	48	.	.	PUNCT
admet-830	133	1	the	the	DET
admet-830	133	2	characteristic	characteristic	ADJ
admet-830	133	3	peaks	peak	NOUN
admet-830	133	4	were	be	AUX
admet-830	133	5	present	present	ADJ
admet-830	133	6	for	for	ADP
admet-830	133	7	the	the	DET
admet-830	133	8	physical	physical	ADJ
admet-830	133	9	mixtures	mixture	NOUN
admet-830	133	10	;	;	PUNCT
admet-830	133	11	however	however	ADV
admet-830	133	12	,	,	PUNCT
admet-830	133	13	the	the	DET
admet-830	133	14	ris	ris	PROPN
admet-830	133	15	endothermic	endothermic	PROPN
admet-830	133	16	peak	peak	PROPN
admet-830	133	17	in	in	ADP
admet-830	133	18	the	the	DET
admet-830	133	19	physical	physical	ADJ
admet-830	133	20	mixture	mixture	NOUN
admet-830	133	21	shifted	shift	VERB
admet-830	133	22	to	to	ADP
admet-830	133	23	approximately	approximately	ADV
admet-830	133	24	177	177	NUM
admet-830	133	25	°	°	ADP
admet-830	133	26	c	c	NOUN
admet-830	133	27	due	due	ADP
admet-830	133	28	to	to	ADP
admet-830	133	29	potential	potential	ADJ
admet-830	133	30	molecular	molecular	ADJ
admet-830	133	31	interaction	interaction	NOUN
admet-830	133	32	with	with	ADP
admet-830	133	33	the	the	DET
admet-830	133	34	silica	silica	NOUN
admet-830	133	35	.	.	PUNCT
admet-830	134	1	the	the	DET
admet-830	134	2	characteristic	characteristic	ADJ
admet-830	134	3	peaks	peak	NOUN
admet-830	134	4	were	be	AUX
admet-830	134	5	absent	absent	ADJ
admet-830	134	6	for	for	ADP
admet-830	134	7	ris	ris	PROPN
admet-830	134	8	-	-	ADJ
admet-830	134	9	slh	slh	NOUN
admet-830	134	10	and	and	CCONJ
admet-830	134	11	lur	lur	PROPN
admet-830	134	12	-	-	PUNCT
admet-830	134	13	slh	slh	PROPN
admet-830	134	14	,	,	PUNCT
admet-830	134	15	confirming	confirm	VERB
admet-830	134	16	that	that	SCONJ
admet-830	134	17	the	the	DET
admet-830	134	18	compounds	compound	NOUN
admet-830	134	19	were	be	AUX
admet-830	134	20	encapsulated	encapsulate	VERB
admet-830	134	21	within	within	ADP
admet-830	134	22	the	the	DET
admet-830	134	23	silica	silica	NOUN
admet-830	134	24	-	-	PUNCT
admet-830	134	25	lipid	lipid	NOUN
admet-830	134	26	matrix	matrix	NOUN
admet-830	134	27	in	in	ADP
admet-830	134	28	a	a	DET
admet-830	134	29	non	non	ADJ
admet-830	134	30	-	-	ADJ
admet-830	134	31	crystalline	crystalline	ADJ
admet-830	134	32	state	state	NOUN
admet-830	134	33	.	.	PUNCT
admet-830	135	1	although	although	SCONJ
admet-830	135	2	dsc	dsc	NOUN
admet-830	135	3	was	be	AUX
admet-830	135	4	not	not	PART
admet-830	135	5	performed	perform	VERB
admet-830	135	6	on	on	ADP
admet-830	135	7	the	the	DET
admet-830	135	8	pre	pre	ADJ
admet-830	135	9	-	-	ADJ
admet-830	135	10	cursor	cursor	ADJ
admet-830	135	11	submicron	submicron	NOUN
admet-830	135	12	emulsions	emulsion	NOUN
admet-830	135	13	,	,	PUNCT
admet-830	135	14	it	it	PRON
admet-830	135	15	is	be	AUX
admet-830	135	16	hypothesised	hypothesise	VERB
admet-830	135	17	that	that	SCONJ
admet-830	135	18	both	both	DET
admet-830	135	19	ris	ris	PROPN
admet-830	135	20	and	and	CCONJ
admet-830	135	21	lur	lur	PROPN
admet-830	135	22	within	within	ADP
admet-830	135	23	the	the	DET
admet-830	135	24	emulsions	emulsion	NOUN
admet-830	135	25	would	would	AUX
admet-830	135	26	be	be	AUX
admet-830	135	27	non	non	ADJ
admet-830	135	28	-	-	ADJ
admet-830	135	29	crystalline	crystalline	ADJ
admet-830	135	30	due	due	ADP
admet-830	135	31	to	to	ADP
admet-830	135	32	being	be	AUX
admet-830	135	33	loaded	load	VERB
admet-830	135	34	at	at	ADP
admet-830	135	35	or	or	CCONJ
admet-830	135	36	below	below	ADP
admet-830	135	37	their	their	PRON
admet-830	135	38	equilibrium	equilibrium	NOUN
admet-830	135	39	solubilities	solubility	NOUN
admet-830	135	40	in	in	ADP
admet-830	135	41	the	the	DET
admet-830	135	42	lipid	lipid	NOUN
admet-830	135	43	.	.	PUNCT
admet-830	136	1	figure	figure	NOUN
admet-830	136	2	3	3	NUM
admet-830	136	3	.	.	PUNCT
admet-830	136	4	dsc	dsc	NOUN
admet-830	136	5	thermograms	thermogram	NOUN
admet-830	136	6	of	of	ADP
admet-830	136	7	(	(	PUNCT
admet-830	136	8	a	a	PRON
admet-830	136	9	)	)	PUNCT
admet-830	136	10	lur	lur	PROPN
admet-830	136	11	formulations	formulation	NOUN
admet-830	136	12	and	and	CCONJ
admet-830	136	13	(	(	PUNCT
admet-830	136	14	b	b	NOUN
admet-830	136	15	)	)	PUNCT
admet-830	136	16	ris	ris	PROPN
admet-830	136	17	formulations	formulation	NOUN
admet-830	136	18	.	.	PUNCT
admet-830	137	1	in	in	ADP
admet-830	137	2	vitro	vitro	X
admet-830	137	3	dissolution	dissolution	NOUN
admet-830	137	4	and	and	CCONJ
admet-830	137	5	release	release	VERB
admet-830	137	6	studies	study	NOUN
admet-830	137	7	impact	impact	NOUN
admet-830	137	8	of	of	ADP
admet-830	137	9	lur	lur	PROPN
admet-830	137	10	reformulation	reformulation	PROPN
admet-830	137	11	on	on	ADP
admet-830	137	12	dissolution	dissolution	NOUN
admet-830	137	13	and	and	CCONJ
admet-830	137	14	release	release	NOUN
admet-830	137	15	in	in	ADP
admet-830	137	16	vitro	vitro	X
admet-830	137	17	dissolution	dissolution	NOUN
admet-830	137	18	and	and	CCONJ
admet-830	137	19	release	release	NOUN
admet-830	137	20	studies	study	NOUN
admet-830	137	21	were	be	AUX
admet-830	137	22	conducted	conduct	VERB
admet-830	137	23	in	in	ADP
admet-830	137	24	simulated	simulated	ADJ
admet-830	137	25	intestinal	intestinal	ADJ
admet-830	137	26	media	medium	NOUN
admet-830	137	27	under	under	ADP
admet-830	137	28	non	non	ADJ
admet-830	137	29	-	-	ADJ
admet-830	137	30	sink	sink	ADJ
admet-830	137	31	conditions	condition	NOUN
admet-830	137	32	.	.	PUNCT
admet-830	138	1	pure	pure	ADJ
admet-830	138	2	lur	lur	PROPN
admet-830	138	3	exhibited	exhibit	VERB
admet-830	138	4	the	the	DET
admet-830	138	5	lowest	low	ADJ
admet-830	138	6	rate	rate	NOUN
admet-830	138	7	and	and	CCONJ
admet-830	138	8	extent	extent	NOUN
admet-830	138	9	of	of	ADP
admet-830	138	10	dissolution	dissolution	NOUN
admet-830	138	11	reaching	reach	VERB
admet-830	138	12	a	a	DET
admet-830	138	13	maximum	maximum	NOUN
admet-830	138	14	of	of	ADP
admet-830	138	15	16.0	16.0	NUM
admet-830	138	16	±	±	NUM
admet-830	138	17	0.5	0.5	NUM
admet-830	138	18	%	%	NOUN
admet-830	138	19	(	(	PUNCT
admet-830	138	20	1.2	1.2	NUM
admet-830	138	21	µg	µg	NOUN
admet-830	138	22	/	/	SYM
admet-830	138	23	ml	ml	NOUN
admet-830	138	24	)	)	PUNCT
admet-830	138	25	after	after	ADP
admet-830	138	26	2	2	NUM
admet-830	138	27	h	h	NOUN
admet-830	138	28	,	,	PUNCT
admet-830	138	29	reflecting	reflect	VERB
admet-830	138	30	the	the	DET
admet-830	138	31	drug	drug	NOUN
admet-830	138	32	’s	’s	PART
admet-830	138	33	poor	poor	ADJ
admet-830	138	34	aqueous	aqueous	ADJ
admet-830	138	35	solubility	solubility	NOUN
admet-830	138	36	and	and	CCONJ
admet-830	138	37	crystalline	crystalline	ADJ
admet-830	138	38	nature	nature	NOUN
admet-830	138	39	(	(	PUNCT
admet-830	138	40	figure	figure	NOUN
admet-830	138	41	4	4	NUM
admet-830	138	42	)	)	PUNCT
admet-830	138	43	.	.	PUNCT
admet-830	139	1	when	when	SCONJ
admet-830	139	2	formulated	formulate	VERB
admet-830	139	3	as	as	ADP
admet-830	139	4	a	a	DET
admet-830	139	5	submicron	submicron	NOUN
admet-830	139	6	emulsion	emulsion	NOUN
admet-830	139	7	,	,	PUNCT
admet-830	139	8	the	the	DET
admet-830	139	9	release	release	NOUN
admet-830	139	10	of	of	ADP
admet-830	139	11	lur	lur	PROPN
admet-830	139	12	was	be	AUX
admet-830	139	13	enhanced	enhance	VERB
admet-830	139	14	3.4	3.4	NUM
admet-830	139	15	-	-	NUM
admet-830	139	16	fold	fold	ADJ
admet-830	139	17	,	,	PUNCT
admet-830	139	18	compared	compare	VERB
admet-830	139	19	to	to	ADP
admet-830	139	20	pure	pure	ADJ
admet-830	139	21	lur	lur	PROPN
admet-830	139	22	(	(	PUNCT
admet-830	139	23	52.9	52.9	NUM
admet-830	139	24	±	±	NUM
admet-830	139	25	0.8	0.8	NUM
admet-830	139	26	%	%	NOUN
admet-830	139	27	release	release	NOUN
admet-830	139	28	,	,	PUNCT
admet-830	139	29	3.9	3.9	NUM
admet-830	139	30	µg	µg	NOUN
admet-830	139	31	/	/	SYM
admet-830	139	32	ml	ml	NOUN
admet-830	139	33	)	)	PUNCT
admet-830	139	34	.	.	PUNCT
admet-830	140	1	it	it	PRON
admet-830	140	2	is	be	AUX
admet-830	140	3	postulated	postulate	VERB
admet-830	140	4	that	that	SCONJ
admet-830	140	5	this	this	PRON
admet-830	140	6	is	be	AUX
admet-830	140	7	due	due	ADJ
admet-830	140	8	to	to	ADP
admet-830	140	9	the	the	DET
admet-830	140	10	pre	pre	NOUN
admet-830	140	11	-	-	NOUN
admet-830	140	12	solubilisation	solubilisation	NOUN
admet-830	140	13	of	of	ADP
admet-830	140	14	the	the	DET
admet-830	140	15	drug	drug	NOUN
admet-830	140	16	in	in	ADP
admet-830	140	17	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	140	18	admet	admet	PROPN
admet-830	140	19	&	&	CCONJ
admet-830	140	20	dmpk	dmpk	PROPN
admet-830	140	21	8(4	8(4	NOUN
admet-830	140	22	)	)	PUNCT
admet-830	140	23	(	(	PUNCT
admet-830	140	24	2020	2020	NUM
admet-830	140	25	)	)	PUNCT
admet-830	140	26	437	437	NUM
admet-830	140	27	-	-	SYM
admet-830	140	28	451	451	NUM
admet-830	140	29	drug	drug	NOUN
admet-830	140	30	ionisation	ionisation	NOUN
admet-830	140	31	and	and	CCONJ
admet-830	140	32	lipid	lipid	NOUN
admet-830	140	33	-	-	PUNCT
admet-830	140	34	based	base	VERB
admet-830	140	35	formulations	formulation	NOUN
admet-830	140	36	doi	doi	NOUN
admet-830	140	37	:	:	PUNCT
admet-830	140	38	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	140	39	444	444	NUM
admet-830	140	40	the	the	DET
admet-830	140	41	lipid	lipid	NOUN
admet-830	140	42	,	,	PUNCT
admet-830	140	43	therefore	therefore	ADV
admet-830	140	44	avoiding	avoid	VERB
admet-830	140	45	the	the	DET
admet-830	140	46	critical	critical	ADJ
admet-830	140	47	rate	rate	NOUN
admet-830	140	48	-	-	PUNCT
admet-830	140	49	limiting	limit	VERB
admet-830	140	50	dissolution	dissolution	NOUN
admet-830	140	51	step	step	NOUN
admet-830	140	52	.	.	PUNCT
admet-830	141	1	lur	lur	PROPN
admet-830	141	2	-	-	PUNCT
admet-830	141	3	slh	slh	PROPN
admet-830	141	4	displayed	display	VERB
admet-830	141	5	a	a	DET
admet-830	141	6	rapid	rapid	ADJ
admet-830	141	7	release	release	NOUN
admet-830	141	8	of	of	ADP
admet-830	141	9	lur	lur	PROPN
admet-830	141	10	,	,	PUNCT
admet-830	141	11	achieving	achieve	VERB
admet-830	141	12	complete	complete	ADJ
admet-830	141	13	drug	drug	NOUN
admet-830	141	14	release	release	NOUN
admet-830	141	15	after	after	ADP
admet-830	141	16	a	a	DET
admet-830	141	17	10	10	NUM
admet-830	141	18	min	min	NOUN
admet-830	141	19	period	period	NOUN
admet-830	141	20	.	.	PUNCT
admet-830	142	1	similar	similar	ADJ
admet-830	142	2	to	to	ADP
admet-830	142	3	the	the	DET
admet-830	142	4	submicron	submicron	NOUN
admet-830	142	5	emulsion	emulsion	NOUN
admet-830	142	6	,	,	PUNCT
admet-830	142	7	the	the	DET
admet-830	142	8	rapid	rapid	ADJ
admet-830	142	9	release	release	NOUN
admet-830	142	10	rate	rate	NOUN
admet-830	142	11	of	of	ADP
admet-830	142	12	lur	lur	PROPN
admet-830	142	13	-	-	PUNCT
admet-830	142	14	slh	slh	PROPN
admet-830	142	15	can	can	AUX
admet-830	142	16	be	be	AUX
admet-830	142	17	explained	explain	VERB
admet-830	142	18	by	by	ADP
admet-830	142	19	the	the	DET
admet-830	142	20	encapsulation	encapsulation	NOUN
admet-830	142	21	of	of	ADP
admet-830	142	22	lur	lur	PROPN
admet-830	142	23	in	in	ADP
admet-830	142	24	the	the	DET
admet-830	142	25	non	non	ADJ
admet-830	142	26	-	-	ADJ
admet-830	142	27	crystalline	crystalline	ADJ
admet-830	142	28	state	state	NOUN
admet-830	142	29	.	.	PUNCT
admet-830	143	1	however	however	ADV
admet-830	143	2	,	,	PUNCT
admet-830	143	3	it	it	PRON
admet-830	143	4	is	be	AUX
admet-830	143	5	apparent	apparent	ADJ
admet-830	143	6	that	that	SCONJ
admet-830	143	7	the	the	DET
admet-830	143	8	1.9	1.9	NUM
admet-830	143	9	-	-	ADJ
admet-830	143	10	fold	fold	ADJ
admet-830	143	11	enhancement	enhancement	NOUN
admet-830	143	12	in	in	ADP
admet-830	143	13	drug	drug	NOUN
admet-830	143	14	release	release	NOUN
admet-830	143	15	,	,	PUNCT
admet-830	143	16	compared	compare	VERB
admet-830	143	17	to	to	ADP
admet-830	143	18	the	the	DET
admet-830	143	19	submicron	submicron	NOUN
admet-830	143	20	emulsion	emulsion	NOUN
admet-830	143	21	,	,	PUNCT
admet-830	143	22	is	be	AUX
admet-830	143	23	due	due	ADJ
admet-830	143	24	to	to	ADP
admet-830	143	25	the	the	DET
admet-830	143	26	presence	presence	NOUN
admet-830	143	27	of	of	ADP
admet-830	143	28	hydrophilic	hydrophilic	ADJ
admet-830	143	29	silica	silica	NOUN
admet-830	143	30	and	and	CCONJ
admet-830	143	31	porous	porous	ADJ
admet-830	143	32	structure	structure	NOUN
admet-830	143	33	,	,	PUNCT
admet-830	143	34	aiding	aid	VERB
admet-830	143	35	in	in	ADP
admet-830	143	36	drug	drug	NOUN
admet-830	143	37	wettability	wettability	NOUN
admet-830	143	38	and	and	CCONJ
admet-830	143	39	dissolution	dissolution	NOUN
admet-830	144	1	[	[	X
admet-830	144	2	16	16	NUM
admet-830	144	3	]	]	PUNCT
admet-830	144	4	.	.	PUNCT
admet-830	145	1	figure	figure	NOUN
admet-830	145	2	4	4	NUM
admet-830	145	3	.	.	PUNCT
admet-830	146	1	in	in	ADP
admet-830	146	2	vitro	vitro	X
admet-830	146	3	dissolution	dissolution	ADJ
admet-830	146	4	profiles	profile	NOUN
admet-830	146	5	of	of	ADP
admet-830	146	6	pure	pure	ADJ
admet-830	146	7	lur	lur	PROPN
admet-830	146	8	[	[	X
admet-830	146	9	▼	▼	X
admet-830	146	10	]	]	X
admet-830	146	11	,	,	PUNCT
admet-830	146	12	lur	lur	PROPN
admet-830	146	13	emulsion	emulsion	NOUN
admet-830	146	14	[	[	X
admet-830	146	15	●	●	NOUN
admet-830	146	16	]	]	X
admet-830	146	17	,	,	PUNCT
admet-830	146	18	and	and	CCONJ
admet-830	146	19	lur	lur	NOUN
admet-830	146	20	-	-	PUNCT
admet-830	146	21	slh	slh	NOUN
admet-830	146	22	[	[	X
admet-830	146	23	■	■	NOUN
admet-830	146	24	]	]	X
admet-830	146	25	.	.	PUNCT
admet-830	147	1	each	each	DET
admet-830	147	2	value	value	NOUN
admet-830	147	3	represents	represent	VERB
admet-830	147	4	the	the	DET
admet-830	147	5	mean	mean	ADJ
admet-830	147	6	±	±	NUM
admet-830	147	7	sd	sd	NOUN
admet-830	147	8	,	,	PUNCT
admet-830	147	9	n	n	NOUN
admet-830	147	10	=	=	SYM
admet-830	147	11	3	3	X
admet-830	147	12	.	.	X
admet-830	147	13	impact	impact	NOUN
admet-830	147	14	of	of	ADP
admet-830	147	15	ris	ris	PROPN
admet-830	147	16	reformulation	reformulation	PROPN
admet-830	147	17	on	on	ADP
admet-830	147	18	dissolution	dissolution	NOUN
admet-830	147	19	and	and	CCONJ
admet-830	147	20	release	release	VERB
admet-830	147	21	the	the	DET
admet-830	147	22	opposite	opposite	ADJ
admet-830	147	23	trend	trend	NOUN
admet-830	147	24	in	in	ADP
admet-830	147	25	performance	performance	NOUN
admet-830	147	26	was	be	AUX
admet-830	147	27	evident	evident	ADJ
admet-830	147	28	for	for	ADP
admet-830	147	29	ris	ris	PROPN
admet-830	147	30	formulations	formulation	NOUN
admet-830	147	31	,	,	PUNCT
admet-830	147	32	whereby	whereby	SCONJ
admet-830	147	33	the	the	DET
admet-830	147	34	dissolution	dissolution	NOUN
admet-830	147	35	of	of	ADP
admet-830	147	36	pure	pure	ADJ
admet-830	147	37	ris	ris	PROPN
admet-830	147	38	was	be	AUX
admet-830	147	39	superior	superior	ADJ
admet-830	147	40	to	to	ADP
admet-830	147	41	both	both	DET
admet-830	147	42	lbfs	lbfs	NOUN
admet-830	147	43	,	,	PUNCT
admet-830	147	44	reaching	reach	VERB
admet-830	147	45	28.0	28.0	NUM
admet-830	147	46	±	±	NUM
admet-830	147	47	1.0	1.0	NUM
admet-830	147	48	%	%	NOUN
admet-830	147	49	(	(	PUNCT
admet-830	147	50	156.1	156.1	NUM
admet-830	147	51	µg	µg	NOUN
admet-830	147	52	/	/	SYM
admet-830	147	53	ml	ml	NOUN
admet-830	147	54	)	)	PUNCT
admet-830	147	55	after	after	ADP
admet-830	147	56	a	a	DET
admet-830	147	57	2	2	NUM
admet-830	147	58	h	h	NOUN
admet-830	147	59	period	period	NOUN
admet-830	147	60	(	(	PUNCT
admet-830	147	61	figure	figure	NOUN
admet-830	147	62	5	5	NUM
admet-830	147	63	)	)	PUNCT
admet-830	147	64	.	.	PUNCT
admet-830	148	1	during	during	ADP
admet-830	148	2	the	the	DET
admet-830	148	3	initial	initial	ADJ
admet-830	148	4	5	5	NUM
admet-830	148	5	min	min	NOUN
admet-830	148	6	,	,	PUNCT
admet-830	148	7	the	the	DET
admet-830	148	8	rate	rate	NOUN
admet-830	148	9	of	of	ADP
admet-830	148	10	ris	ris	PROPN
admet-830	148	11	release	release	NOUN
admet-830	148	12	from	from	ADP
admet-830	148	13	the	the	DET
admet-830	148	14	ris	ris	PROPN
admet-830	148	15	emulsion	emulsion	NOUN
admet-830	148	16	mimicked	mimic	VERB
admet-830	148	17	the	the	DET
admet-830	148	18	release	release	NOUN
admet-830	148	19	of	of	ADP
admet-830	148	20	pure	pure	ADJ
admet-830	148	21	ris	ris	PROPN
admet-830	148	22	,	,	PUNCT
admet-830	148	23	prior	prior	ADV
admet-830	148	24	to	to	ADP
admet-830	148	25	plateauing	plateauing	NOUN
admet-830	148	26	at	at	ADP
admet-830	148	27	17.0	17.0	NUM
admet-830	148	28	±	±	NUM
admet-830	148	29	0.5	0.5	NUM
admet-830	148	30	%	%	NOUN
admet-830	148	31	(	(	PUNCT
admet-830	148	32	83.7	83.7	NUM
admet-830	148	33	µg	µg	NOUN
admet-830	148	34	/	/	SYM
admet-830	148	35	ml	ml	NOUN
admet-830	148	36	)	)	PUNCT
admet-830	148	37	for	for	ADP
admet-830	148	38	the	the	DET
admet-830	148	39	remaining	remain	VERB
admet-830	148	40	experimental	experimental	ADJ
admet-830	148	41	period	period	NOUN
admet-830	148	42	.	.	PUNCT
admet-830	149	1	ris	ris	PROPN
admet-830	149	2	-	-	PROPN
admet-830	149	3	slh	slh	PROPN
admet-830	149	4	exhibited	exhibit	VERB
admet-830	149	5	the	the	DET
admet-830	149	6	lowest	low	ADJ
admet-830	149	7	extent	extent	NOUN
admet-830	149	8	of	of	ADP
admet-830	149	9	drug	drug	NOUN
admet-830	149	10	release	release	NOUN
admet-830	149	11	reaching	reach	VERB
admet-830	149	12	7.7	7.7	NUM
admet-830	149	13	±	±	NUM
admet-830	149	14	0.0	0.0	NUM
admet-830	149	15	%	%	NOUN
admet-830	149	16	(	(	PUNCT
admet-830	149	17	38.5	38.5	NUM
admet-830	149	18	µg	µg	NOUN
admet-830	149	19	/	/	SYM
admet-830	149	20	ml	ml	NOUN
admet-830	149	21	)	)	PUNCT
admet-830	149	22	after	after	ADP
admet-830	149	23	120	120	NUM
admet-830	149	24	min	min	NOUN
admet-830	149	25	,	,	PUNCT
admet-830	149	26	a	a	DET
admet-830	149	27	4	4	NUM
admet-830	149	28	-	-	ADJ
admet-830	149	29	fold	fold	ADJ
admet-830	149	30	reduction	reduction	NOUN
admet-830	149	31	compared	compare	VERB
admet-830	149	32	to	to	ADP
admet-830	149	33	pure	pure	ADJ
admet-830	149	34	drug	drug	NOUN
admet-830	149	35	dissolution	dissolution	NOUN
admet-830	149	36	.	.	PUNCT
admet-830	150	1	to	to	PART
admet-830	150	2	investigate	investigate	VERB
admet-830	150	3	the	the	DET
admet-830	150	4	reason	reason	NOUN
admet-830	150	5	for	for	ADP
admet-830	150	6	this	this	DET
admet-830	150	7	poor	poor	ADJ
admet-830	150	8	performance	performance	NOUN
admet-830	150	9	,	,	PUNCT
admet-830	150	10	a	a	DET
admet-830	150	11	study	study	NOUN
admet-830	150	12	was	be	AUX
admet-830	150	13	conducted	conduct	VERB
admet-830	150	14	to	to	PART
admet-830	150	15	determine	determine	VERB
admet-830	150	16	whether	whether	SCONJ
admet-830	150	17	any	any	DET
admet-830	150	18	interaction	interaction	NOUN
admet-830	150	19	between	between	ADP
admet-830	150	20	silica	silica	NOUN
admet-830	150	21	and	and	CCONJ
admet-830	150	22	ris	ris	PROPN
admet-830	150	23	was	be	AUX
admet-830	150	24	present	present	ADJ
admet-830	150	25	,	,	PUNCT
admet-830	150	26	by	by	ADP
admet-830	150	27	introducing	introduce	VERB
admet-830	150	28	aerosil	aerosil	NOUN
admet-830	150	29	®	®	NOUN
admet-830	150	30	silica	silica	NOUN
admet-830	150	31	to	to	ADP
admet-830	150	32	dissolution	dissolution	ADJ
admet-830	150	33	media	medium	NOUN
admet-830	150	34	containing	contain	VERB
admet-830	150	35	dissolved	dissolve	VERB
admet-830	150	36	ris	ris	PROPN
admet-830	150	37	(	(	PUNCT
admet-830	150	38	figure	figure	NOUN
admet-830	150	39	5b	5b	NUM
admet-830	150	40	)	)	PUNCT
admet-830	150	41	.	.	PUNCT
admet-830	151	1	results	result	NOUN
admet-830	151	2	revealed	reveal	VERB
admet-830	151	3	that	that	SCONJ
admet-830	151	4	the	the	DET
admet-830	151	5	addition	addition	NOUN
admet-830	151	6	of	of	ADP
admet-830	151	7	silica	silica	NOUN
admet-830	151	8	triggered	trigger	VERB
admet-830	151	9	a	a	DET
admet-830	151	10	significant	significant	ADJ
admet-830	151	11	reduction	reduction	NOUN
admet-830	151	12	in	in	ADP
admet-830	151	13	the	the	DET
admet-830	151	14	concentration	concentration	NOUN
admet-830	151	15	of	of	ADP
admet-830	151	16	ris	ris	PROPN
admet-830	151	17	in	in	ADP
admet-830	151	18	solution	solution	NOUN
admet-830	151	19	from	from	ADP
admet-830	151	20	28.0	28.0	NUM
admet-830	151	21	%	%	NOUN
admet-830	151	22	to	to	ADP
admet-830	151	23	15.2	15.2	NUM
admet-830	151	24	±	±	NUM
admet-830	151	25	0.5	0.5	NUM
admet-830	151	26	%	%	NOUN
admet-830	151	27	.	.	PUNCT
admet-830	152	1	this	this	PRON
admet-830	152	2	was	be	AUX
admet-830	152	3	hypothesised	hypothesise	VERB
admet-830	152	4	to	to	PART
admet-830	152	5	be	be	AUX
admet-830	152	6	due	due	ADJ
admet-830	152	7	to	to	ADP
admet-830	152	8	the	the	DET
admet-830	152	9	ionic	ionic	ADJ
admet-830	152	10	interactions	interaction	NOUN
admet-830	152	11	and	and	CCONJ
admet-830	152	12	adsorption	adsorption	NOUN
admet-830	152	13	of	of	ADP
admet-830	152	14	the	the	DET
admet-830	152	15	positively	positively	ADV
admet-830	152	16	charged	charge	VERB
admet-830	152	17	ris	ris	PROPN
admet-830	152	18	to	to	ADP
admet-830	152	19	the	the	DET
admet-830	152	20	negatively	negatively	ADV
admet-830	152	21	charged	charge	VERB
admet-830	152	22	silica	silica	NOUN
admet-830	152	23	.	.	PUNCT
admet-830	153	1	nevertheless	nevertheless	ADV
admet-830	153	2	,	,	PUNCT
admet-830	153	3	drug	drug	NOUN
admet-830	153	4	release	release	NOUN
admet-830	153	5	from	from	ADP
admet-830	153	6	the	the	DET
admet-830	153	7	ris	ris	PROPN
admet-830	153	8	emulsion	emulsion	NOUN
admet-830	153	9	was	be	AUX
admet-830	153	10	inferior	inferior	ADJ
admet-830	153	11	to	to	ADP
admet-830	153	12	pure	pure	VERB
admet-830	153	13	ris	ris	PROPN
admet-830	153	14	,	,	PUNCT
admet-830	153	15	even	even	ADV
admet-830	153	16	though	though	SCONJ
admet-830	153	17	silica	silica	NOUN
admet-830	153	18	was	be	AUX
admet-830	153	19	absent	absent	ADJ
admet-830	153	20	.	.	PUNCT
admet-830	154	1	therefore	therefore	ADV
admet-830	154	2	,	,	PUNCT
admet-830	154	3	it	it	PRON
admet-830	154	4	is	be	AUX
admet-830	154	5	reasonable	reasonable	ADJ
admet-830	154	6	to	to	PART
admet-830	154	7	suggest	suggest	VERB
admet-830	154	8	that	that	SCONJ
admet-830	154	9	due	due	ADP
admet-830	154	10	to	to	ADP
admet-830	154	11	the	the	DET
admet-830	154	12	lipophilic	lipophilic	ADJ
admet-830	154	13	nature	nature	NOUN
admet-830	154	14	of	of	ADP
admet-830	154	15	ris	ris	PROPN
admet-830	154	16	(	(	PUNCT
admet-830	154	17	log	log	NOUN
admet-830	154	18	p	p	NOUN
admet-830	154	19	=	=	NOUN
admet-830	154	20	3.04	3.04	NUM
admet-830	154	21	)	)	PUNCT
admet-830	155	1	[	[	X
admet-830	155	2	21	21	NUM
admet-830	155	3	]	]	PUNCT
admet-830	155	4	,	,	PUNCT
admet-830	155	5	ris	ris	PROPN
admet-830	155	6	favours	favour	VERB
admet-830	155	7	capmul	capmul	PROPN
admet-830	155	8	®	®	PROPN
admet-830	155	9	mcm	mcm	PROPN
admet-830	155	10	,	,	PUNCT
admet-830	155	11	resulting	result	VERB
admet-830	155	12	in	in	ADP
admet-830	155	13	less	less	ADJ
admet-830	155	14	drug	drug	NOUN
admet-830	155	15	partitioning	partitioning	NOUN
admet-830	155	16	into	into	ADP
admet-830	155	17	the	the	DET
admet-830	155	18	aqueous	aqueous	ADJ
admet-830	155	19	phase	phase	NOUN
admet-830	155	20	and	and	CCONJ
admet-830	155	21	reducing	reduce	VERB
admet-830	155	22	the	the	DET
admet-830	155	23	overall	overall	ADJ
admet-830	155	24	extent	extent	NOUN
admet-830	155	25	of	of	ADP
admet-830	155	26	drug	drug	NOUN
admet-830	155	27	release	release	NOUN
admet-830	155	28	.	.	PUNCT
admet-830	156	1	it	it	PRON
admet-830	156	2	is	be	AUX
admet-830	156	3	recognised	recognise	VERB
admet-830	156	4	that	that	SCONJ
admet-830	156	5	a	a	DET
admet-830	156	6	limitation	limitation	NOUN
admet-830	156	7	exists	exist	VERB
admet-830	156	8	when	when	SCONJ
admet-830	156	9	analysing	analyse	VERB
admet-830	156	10	lbfs	lbfs	NOUN
admet-830	156	11	during	during	ADP
admet-830	156	12	in	in	ADP
admet-830	156	13	vitro	vitro	X
admet-830	156	14	release	release	NOUN
admet-830	156	15	studies	study	NOUN
admet-830	156	16	as	as	SCONJ
admet-830	156	17	no	no	DET
admet-830	156	18	enzyme	enzyme	NOUN
admet-830	156	19	is	be	AUX
admet-830	156	20	present	present	ADJ
admet-830	156	21	to	to	PART
admet-830	156	22	digest	digest	VERB
admet-830	156	23	the	the	DET
admet-830	156	24	lipid	lipid	NOUN
admet-830	156	25	to	to	PART
admet-830	156	26	release	release	VERB
admet-830	156	27	the	the	DET
admet-830	156	28	drug	drug	NOUN
admet-830	156	29	and	and	CCONJ
admet-830	156	30	thus	thus	ADV
admet-830	156	31	,	,	PUNCT
admet-830	156	32	the	the	DET
admet-830	156	33	formulation	formulation	NOUN
admet-830	156	34	performance	performance	NOUN
admet-830	156	35	may	may	AUX
admet-830	156	36	be	be	AUX
admet-830	156	37	underestimated	underestimate	VERB
admet-830	156	38	.	.	PUNCT
admet-830	157	1	hence	hence	ADV
admet-830	157	2	,	,	PUNCT
admet-830	157	3	in	in	ADP
admet-830	157	4	vitro	vitro	X
admet-830	157	5	solubilisation	solubilisation	NOUN
admet-830	157	6	studies	study	NOUN
admet-830	157	7	under	under	ADP
admet-830	157	8	digesting	digest	VERB
admet-830	157	9	conditions	condition	NOUN
admet-830	157	10	were	be	AUX
admet-830	157	11	subsequently	subsequently	ADV
admet-830	157	12	performed	perform	VERB
admet-830	157	13	.	.	PUNCT
admet-830	158	1	in	in	ADP
admet-830	158	2	vitro	vitro	X
admet-830	158	3	solubilisation	solubilisation	NOUN
admet-830	158	4	studies	study	NOUN
admet-830	158	5	under	under	ADP
admet-830	158	6	digesting	digest	VERB
admet-830	158	7	conditions	condition	NOUN
admet-830	158	8	impact	impact	NOUN
admet-830	158	9	of	of	ADP
admet-830	158	10	lur	lur	PROPN
admet-830	158	11	reformulation	reformulation	NOUN
admet-830	158	12	on	on	ADP
admet-830	158	13	lipolysis	lipolysis	NOUN
admet-830	158	14	and	and	CCONJ
admet-830	158	15	drug	drug	NOUN
admet-830	158	16	solubilisation	solubilisation	NOUN
admet-830	158	17	similar	similar	ADJ
admet-830	158	18	to	to	ADP
admet-830	158	19	the	the	DET
admet-830	158	20	previous	previous	ADJ
admet-830	158	21	dissolution	dissolution	NOUN
admet-830	158	22	study	study	NOUN
admet-830	158	23	,	,	PUNCT
admet-830	158	24	lbfs	lbfs	NOUN
admet-830	158	25	were	be	AUX
admet-830	158	26	successful	successful	ADJ
admet-830	158	27	in	in	ADP
admet-830	158	28	significantly	significantly	ADV
admet-830	158	29	enhancing	enhance	VERB
admet-830	158	30	the	the	DET
admet-830	158	31	solubilisation	solubilisation	NOUN
admet-830	158	32	of	of	ADP
admet-830	158	33	lur	lur	PROPN
admet-830	158	34	under	under	ADP
admet-830	158	35	digesting	digest	VERB
admet-830	158	36	conditions	condition	NOUN
admet-830	158	37	,	,	PUNCT
admet-830	158	38	when	when	SCONJ
admet-830	158	39	compared	compare	VERB
admet-830	158	40	to	to	ADP
admet-830	158	41	pure	pure	ADJ
admet-830	158	42	drug	drug	NOUN
admet-830	158	43	(	(	PUNCT
admet-830	158	44	figure	figure	VERB
admet-830	158	45	6a	6a	NOUN
admet-830	158	46	)	)	PUNCT
admet-830	158	47	.	.	PUNCT
admet-830	159	1	after	after	ADP
admet-830	159	2	the	the	DET
admet-830	159	3	60	60	NUM
admet-830	159	4	min	min	NOUN
admet-830	159	5	experimental	experimental	ADJ
admet-830	159	6	period	period	NOUN
admet-830	159	7	,	,	PUNCT
admet-830	159	8	lur	lur	PROPN
admet-830	159	9	-	-	PUNCT
admet-830	159	10	slh	slh	PROPN
admet-830	159	11	achieved	achieve	VERB
admet-830	159	12	the	the	DET
admet-830	159	13	highest	high	ADJ
admet-830	159	14	drug	drug	NOUN
admet-830	159	15	solubilisation	solubilisation	NOUN
admet-830	159	16	of	of	ADP
admet-830	159	17	2.7	2.7	NUM
admet-830	159	18	±	±	NUM
admet-830	159	19	0.2	0.2	NUM
admet-830	159	20	%	%	NOUN
admet-830	159	21	(	(	PUNCT
admet-830	159	22	6.6	6.6	NUM
admet-830	159	23	µg	µg	NOUN
admet-830	159	24	/	/	SYM
admet-830	159	25	ml	ml	NOUN
admet-830	159	26	)	)	PUNCT
admet-830	159	27	,	,	PUNCT
admet-830	159	28	compared	compare	VERB
admet-830	159	29	to	to	ADP
admet-830	159	30	the	the	DET
admet-830	159	31	lur	lur	NOUN
admet-830	159	32	emulsion	emulsion	NOUN
admet-830	159	33	which	which	PRON
admet-830	159	34	reached	reach	VERB
admet-830	159	35	1.2	1.2	NUM
admet-830	159	36	±	±	NOUN
admet-830	159	37	0.0	0.0	NUM
admet-830	159	38	%	%	NOUN
admet-830	159	39	(	(	PUNCT
admet-830	159	40	4.7	4.7	NUM
admet-830	159	41	µg	µg	ADJ
admet-830	159	42	/	/	SYM
admet-830	159	43	ml	ml	NOUN
admet-830	159	44	)	)	PUNCT
admet-830	159	45	solubilisation	solubilisation	NOUN
admet-830	159	46	.	.	PUNCT
admet-830	160	1	only	only	ADV
admet-830	160	2	0.1	0.1	NUM
admet-830	160	3	±	±	NUM
admet-830	160	4	0.0	0.0	NUM
admet-830	160	5	%	%	NOUN
admet-830	160	6	percent	percent	NOUN
admet-830	160	7	of	of	ADP
admet-830	160	8	the	the	DET
admet-830	160	9	pure	pure	ADJ
admet-830	160	10	drug	drug	NOUN
admet-830	160	11	was	be	AUX
admet-830	160	12	solubilised	solubilise	VERB
admet-830	160	13	in	in	ADP
admet-830	160	14	fasted	fasted	ADJ
admet-830	160	15	state	state	NOUN
admet-830	160	16	digesting	digesting	NOUN
admet-830	160	17	conditions	condition	NOUN
admet-830	160	18	.	.	PUNCT
admet-830	161	1	the	the	DET
admet-830	161	2	enhancement	enhancement	NOUN
admet-830	161	3	in	in	ADP
admet-830	161	4	lur	lur	PROPN
admet-830	161	5	solubilisation	solubilisation	NOUN
admet-830	161	6	from	from	ADP
admet-830	161	7	both	both	DET
admet-830	161	8	lbfs	lbfs	NOUN
admet-830	161	9	is	be	AUX
admet-830	161	10	attributable	attributable	ADJ
admet-830	161	11	to	to	ADP
admet-830	161	12	the	the	DET
admet-830	161	13	digestion	digestion	NOUN
admet-830	161	14	of	of	ADP
admet-830	161	15	the	the	DET
admet-830	161	16	lipid	lipid	NOUN
admet-830	161	17	component	component	NOUN
admet-830	161	18	,	,	PUNCT
admet-830	161	19	which	which	PRON
admet-830	161	20	triggers	trigger	VERB
admet-830	161	21	the	the	DET
admet-830	161	22	formation	formation	NOUN
admet-830	161	23	of	of	ADP
admet-830	161	24	colloidal	colloidal	NOUN
admet-830	161	25	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	161	26	admet	admet	PROPN
admet-830	161	27	&	&	CCONJ
admet-830	161	28	dmpk	dmpk	PROPN
admet-830	161	29	8(4	8(4	NOUN
admet-830	161	30	)	)	PUNCT
admet-830	161	31	(	(	PUNCT
admet-830	161	32	2020	2020	NUM
admet-830	161	33	)	)	PUNCT
admet-830	161	34	437	437	NUM
admet-830	161	35	-	-	SYM
admet-830	161	36	451	451	NUM
admet-830	161	37	drug	drug	NOUN
admet-830	161	38	ionisation	ionisation	NOUN
admet-830	161	39	and	and	CCONJ
admet-830	161	40	lipid	lipid	NOUN
admet-830	161	41	-	-	PUNCT
admet-830	161	42	based	base	VERB
admet-830	161	43	formulations	formulation	NOUN
admet-830	161	44	doi	doi	NOUN
admet-830	161	45	:	:	PUNCT
admet-830	161	46	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	161	47	445	445	NUM
admet-830	161	48	species	specie	NOUN
admet-830	161	49	,	,	PUNCT
admet-830	161	50	composed	compose	VERB
admet-830	161	51	primarily	primarily	ADV
admet-830	161	52	of	of	ADP
admet-830	161	53	monoand	monoand	NOUN
admet-830	161	54	di	di	NOUN
admet-830	161	55	-	-	PUNCT
admet-830	161	56	glycerides	glyceride	NOUN
admet-830	161	57	and	and	CCONJ
admet-830	161	58	fatty	fatty	NOUN
admet-830	161	59	acids	acid	NOUN
admet-830	161	60	.	.	PUNCT
admet-830	162	1	these	these	DET
admet-830	162	2	colloidal	colloidal	NOUN
admet-830	162	3	lipid	lipid	NOUN
admet-830	162	4	species	specie	NOUN
admet-830	162	5	,	,	PUNCT
admet-830	162	6	such	such	ADJ
admet-830	162	7	as	as	ADP
admet-830	162	8	micelles	micelle	NOUN
admet-830	162	9	,	,	PUNCT
admet-830	162	10	mixed	mixed	ADJ
admet-830	162	11	micelles	micelle	NOUN
admet-830	162	12	and	and	CCONJ
admet-830	162	13	vesicles	vesicle	NOUN
admet-830	162	14	,	,	PUNCT
admet-830	162	15	have	have	AUX
admet-830	162	16	demonstrated	demonstrate	VERB
admet-830	162	17	the	the	DET
admet-830	162	18	ability	ability	NOUN
admet-830	162	19	to	to	PART
admet-830	162	20	improve	improve	VERB
admet-830	162	21	the	the	DET
admet-830	162	22	dissolution	dissolution	NOUN
admet-830	162	23	of	of	ADP
admet-830	162	24	numerous	numerous	ADJ
admet-830	162	25	poorly	poorly	ADV
admet-830	162	26	water	water	NOUN
admet-830	162	27	-	-	PUNCT
admet-830	162	28	soluble	soluble	ADJ
admet-830	162	29	drugs	drug	NOUN
admet-830	162	30	[	[	X
admet-830	162	31	7	7	NUM
admet-830	162	32	,	,	PUNCT
admet-830	162	33	26	26	NUM
admet-830	162	34	]	]	PUNCT
admet-830	162	35	,	,	PUNCT
admet-830	162	36	and	and	CCONJ
admet-830	162	37	the	the	DET
admet-830	162	38	improved	improved	ADJ
admet-830	162	39	drug	drug	NOUN
admet-830	162	40	solubilisation	solubilisation	NOUN
admet-830	162	41	during	during	ADP
admet-830	162	42	lipid	lipid	ADJ
admet-830	162	43	digestion	digestion	NOUN
admet-830	162	44	indicates	indicate	VERB
admet-830	162	45	that	that	SCONJ
admet-830	162	46	lur	lur	PROPN
admet-830	162	47	is	be	AUX
admet-830	162	48	readily	readily	ADV
admet-830	162	49	incorporated	incorporate	VERB
admet-830	162	50	within	within	ADP
admet-830	162	51	these	these	DET
admet-830	162	52	species	specie	NOUN
admet-830	162	53	.	.	PUNCT
admet-830	163	1	figure	figure	NOUN
admet-830	163	2	5	5	NUM
admet-830	163	3	.	.	PUNCT
admet-830	164	1	in	in	ADP
admet-830	164	2	vitro	vitro	X
admet-830	164	3	dissolution	dissolution	ADJ
admet-830	164	4	profiles	profile	NOUN
admet-830	164	5	of	of	ADP
admet-830	164	6	(	(	PUNCT
admet-830	164	7	a	a	X
admet-830	164	8	)	)	PUNCT
admet-830	164	9	pure	pure	ADJ
admet-830	164	10	ris	ris	X
admet-830	165	1	[	[	X
admet-830	165	2	▲	▲	PUNCT
admet-830	165	3	]	]	X
admet-830	165	4	,	,	PUNCT
admet-830	165	5	ris	ris	X
admet-830	165	6	emulsion	emulsion	NOUN
admet-830	165	7	[	[	X
admet-830	165	8	◆	◆	NOUN
admet-830	165	9	]	]	X
admet-830	165	10	,	,	PUNCT
admet-830	165	11	and	and	CCONJ
admet-830	165	12	ris	ris	PROPN
admet-830	165	13	-	-	ADJ
admet-830	165	14	slh	slh	NOUN
admet-830	165	15	[	[	X
admet-830	165	16	✕	✕	NOUN
admet-830	165	17	]	]	X
admet-830	165	18	,	,	PUNCT
admet-830	165	19	and	and	CCONJ
admet-830	165	20	(	(	PUNCT
admet-830	165	21	b	b	NOUN
admet-830	165	22	)	)	PUNCT
admet-830	165	23	pure	pure	ADJ
admet-830	165	24	ris	ris	X
admet-830	165	25	solution	solution	NOUN
admet-830	165	26	followed	follow	VERB
admet-830	165	27	by	by	ADP
admet-830	165	28	the	the	DET
admet-830	165	29	addition	addition	NOUN
admet-830	165	30	of	of	ADP
admet-830	165	31	silica	silica	NOUN
admet-830	165	32	at	at	ADP
admet-830	165	33	t	t	PROPN
admet-830	165	34	=	=	SYM
admet-830	165	35	0	0	NUM
admet-830	165	36	min	min	NOUN
admet-830	165	37	.	.	PROPN
admet-830	165	38	each	each	DET
admet-830	165	39	value	value	NOUN
admet-830	165	40	represents	represent	VERB
admet-830	165	41	the	the	DET
admet-830	165	42	mean	mean	ADJ
admet-830	165	43	±	±	NUM
admet-830	165	44	sd	sd	NOUN
admet-830	165	45	,	,	PUNCT
admet-830	165	46	n	n	NOUN
admet-830	165	47	=	=	SYM
admet-830	165	48	3	3	X
admet-830	165	49	.	.	X
admet-830	165	50	figure	figure	NOUN
admet-830	165	51	6	6	NUM
admet-830	165	52	.	.	PUNCT
admet-830	166	1	(	(	PUNCT
admet-830	166	2	a	a	X
admet-830	166	3	)	)	PUNCT
admet-830	166	4	in	in	ADP
admet-830	166	5	vitro	vitro	X
admet-830	166	6	solubilisation	solubilisation	NOUN
admet-830	166	7	profiles	profile	NOUN
admet-830	166	8	under	under	ADP
admet-830	166	9	digesting	digest	VERB
admet-830	166	10	conditions	condition	NOUN
admet-830	166	11	,	,	PUNCT
admet-830	166	12	and	and	CCONJ
admet-830	166	13	(	(	PUNCT
admet-830	166	14	b	b	NOUN
admet-830	166	15	)	)	PUNCT
admet-830	166	16	lipolysis	lipolysis	NOUN
admet-830	166	17	data	datum	NOUN
admet-830	166	18	for	for	ADP
admet-830	166	19	pure	pure	ADJ
admet-830	166	20	lur	lur	PROPN
admet-830	167	1	[	[	X
admet-830	167	2	▼	▼	X
admet-830	167	3	]	]	X
admet-830	167	4	,	,	PUNCT
admet-830	167	5	lur	lur	PROPN
admet-830	167	6	emulsion	emulsion	NOUN
admet-830	168	1	[	[	X
admet-830	168	2	●	●	NOUN
admet-830	168	3	]	]	X
admet-830	168	4	,	,	PUNCT
admet-830	168	5	and	and	CCONJ
admet-830	168	6	lur	lur	NOUN
admet-830	168	7	-	-	PUNCT
admet-830	168	8	slh	slh	NOUN
admet-830	168	9	[	[	X
admet-830	168	10	■	■	NOUN
admet-830	168	11	]	]	X
admet-830	168	12	.	.	PUNCT
admet-830	169	1	each	each	DET
admet-830	169	2	value	value	NOUN
admet-830	169	3	represents	represent	VERB
admet-830	169	4	the	the	DET
admet-830	169	5	mean	mean	ADJ
admet-830	169	6	±	±	NUM
admet-830	169	7	sd	sd	NOUN
admet-830	169	8	,	,	PUNCT
admet-830	169	9	n	n	NOUN
admet-830	169	10	=	=	SYM
admet-830	169	11	3	3	X
admet-830	169	12	.	.	PUNCT
admet-830	169	13	in	in	ADP
admet-830	169	14	vitro	vitro	X
admet-830	169	15	lipase	lipase	NOUN
admet-830	169	16	-	-	PUNCT
admet-830	169	17	mediated	mediate	VERB
admet-830	169	18	digestion	digestion	NOUN
admet-830	169	19	of	of	ADP
admet-830	169	20	lur	lur	PROPN
admet-830	169	21	lbfs	lbfs	NOUN
admet-830	169	22	,	,	PUNCT
admet-830	169	23	under	under	ADP
admet-830	169	24	simulated	simulate	VERB
admet-830	169	25	intestinal	intestinal	ADJ
admet-830	169	26	fasted	fast	VERB
admet-830	169	27	state	state	NOUN
admet-830	169	28	conditions	condition	NOUN
admet-830	169	29	,	,	PUNCT
admet-830	169	30	revealed	reveal	VERB
admet-830	169	31	that	that	SCONJ
admet-830	169	32	lur	lur	PROPN
admet-830	169	33	-	-	PUNCT
admet-830	169	34	slh	slh	PROPN
admet-830	169	35	enhanced	enhance	VERB
admet-830	169	36	lipolysis	lipolysis	NOUN
admet-830	169	37	,	,	PUNCT
admet-830	169	38	compared	compare	VERB
admet-830	169	39	to	to	ADP
admet-830	169	40	the	the	DET
admet-830	169	41	lur	lur	PROPN
admet-830	169	42	emulsion	emulsion	NOUN
admet-830	169	43	,	,	PUNCT
admet-830	169	44	by	by	ADP
admet-830	169	45	digesting	digest	VERB
admet-830	169	46	33.0	33.0	NUM
admet-830	169	47	±	±	NUM
admet-830	169	48	0.3	0.3	NUM
admet-830	169	49	%	%	NOUN
admet-830	169	50	of	of	ADP
admet-830	169	51	lipid	lipid	NOUN
admet-830	169	52	hosted	host	VERB
admet-830	169	53	within	within	ADP
admet-830	169	54	the	the	DET
admet-830	169	55	porous	porous	ADJ
admet-830	169	56	silica	silica	NOUN
admet-830	169	57	matrix	matrix	NOUN
admet-830	169	58	(	(	PUNCT
admet-830	169	59	figure	figure	NOUN
admet-830	169	60	6b	6b	NUM
admet-830	169	61	)	)	PUNCT
admet-830	169	62	.	.	PUNCT
admet-830	170	1	in	in	ADP
admet-830	170	2	contrast	contrast	NOUN
admet-830	170	3	,	,	PUNCT
admet-830	170	4	only	only	ADV
admet-830	170	5	24.1	24.1	NUM
admet-830	170	6	±	±	NUM
admet-830	170	7	0.2	0.2	NUM
admet-830	170	8	%	%	NOUN
admet-830	170	9	of	of	ADP
admet-830	170	10	the	the	DET
admet-830	170	11	lur	lur	NOUN
admet-830	170	12	emulsion	emulsion	NOUN
admet-830	170	13	was	be	AUX
admet-830	170	14	digested	digest	VERB
admet-830	170	15	over	over	ADP
admet-830	170	16	the	the	DET
admet-830	170	17	course	course	NOUN
admet-830	170	18	of	of	ADP
admet-830	170	19	60	60	NUM
admet-830	170	20	min	min	NOUN
admet-830	170	21	lipolysis	lipolysis	NOUN
admet-830	170	22	period	period	NOUN
admet-830	170	23	.	.	PUNCT
admet-830	171	1	this	this	PRON
admet-830	171	2	is	be	AUX
admet-830	171	3	in	in	ADP
admet-830	171	4	accordance	accordance	NOUN
admet-830	171	5	with	with	ADP
admet-830	171	6	previous	previous	ADJ
admet-830	171	7	studies	study	NOUN
admet-830	171	8	that	that	PRON
admet-830	171	9	have	have	AUX
admet-830	171	10	highlighted	highlight	VERB
admet-830	171	11	the	the	DET
admet-830	171	12	increased	increase	VERB
admet-830	171	13	surface	surface	NOUN
admet-830	171	14	area	area	NOUN
admet-830	171	15	of	of	ADP
admet-830	171	16	the	the	DET
admet-830	171	17	porous	porous	ADJ
admet-830	171	18	silica	silica	NOUN
admet-830	171	19	matrix	matrix	NOUN
admet-830	171	20	affords	afford	NOUN
admet-830	171	21	enhanced	enhance	VERB
admet-830	171	22	adsorption	adsorption	NOUN
admet-830	171	23	of	of	ADP
admet-830	171	24	lipase	lipase	NOUN
admet-830	171	25	molecules	molecule	NOUN
admet-830	171	26	in	in	ADP
admet-830	171	27	their	their	PRON
admet-830	171	28	active	active	ADJ
admet-830	171	29	conformation	conformation	NOUN
admet-830	171	30	,	,	PUNCT
admet-830	171	31	triggering	trigger	VERB
admet-830	171	32	an	an	DET
admet-830	171	33	increase	increase	NOUN
admet-830	171	34	in	in	ADP
admet-830	171	35	catalytic	catalytic	ADJ
admet-830	171	36	activity	activity	NOUN
admet-830	171	37	[	[	X
admet-830	171	38	27	27	NUM
admet-830	171	39	]	]	PUNCT
admet-830	171	40	.	.	PUNCT
admet-830	172	1	furthermore	furthermore	ADV
admet-830	172	2	,	,	PUNCT
admet-830	172	3	owing	owe	VERB
admet-830	172	4	to	to	ADP
admet-830	172	5	the	the	DET
admet-830	172	6	negatively	negatively	ADV
admet-830	172	7	charged	charge	VERB
admet-830	172	8	aerosil	aerosil	NOUN
admet-830	172	9	®	®	NOUN
admet-830	172	10	silica	silica	NOUN
admet-830	172	11	,	,	PUNCT
admet-830	172	12	the	the	DET
admet-830	172	13	digestion	digestion	NOUN
admet-830	172	14	of	of	ADP
admet-830	172	15	slh	slh	PROPN
admet-830	172	16	has	have	AUX
admet-830	172	17	shown	show	VERB
admet-830	172	18	to	to	PART
admet-830	172	19	trigger	trigger	VERB
admet-830	172	20	the	the	DET
admet-830	172	21	release	release	NOUN
admet-830	172	22	and	and	CCONJ
admet-830	172	23	repel	repel	VERB
admet-830	172	24	the	the	DET
admet-830	172	25	negatively	negatively	ADV
admet-830	172	26	charged	charge	VERB
admet-830	172	27	free	free	ADJ
admet-830	172	28	fatty	fatty	NOUN
admet-830	172	29	acids	acid	NOUN
admet-830	172	30	from	from	ADP
admet-830	172	31	the	the	DET
admet-830	172	32	nanostructured	nanostructure	VERB
admet-830	172	33	matrix	matrix	NOUN
admet-830	172	34	into	into	ADP
admet-830	172	35	the	the	DET
admet-830	172	36	aqueous	aqueous	ADJ
admet-830	172	37	phase	phase	NOUN
admet-830	172	38	[	[	X
admet-830	172	39	19	19	NUM
admet-830	172	40	]	]	PUNCT
admet-830	172	41	.	.	PUNCT
admet-830	173	1	the	the	DET
admet-830	173	2	ability	ability	NOUN
admet-830	173	3	for	for	ADP
admet-830	173	4	slh	slh	NOUN
admet-830	173	5	to	to	PART
admet-830	173	6	promote	promote	VERB
admet-830	173	7	lipid	lipid	ADJ
admet-830	173	8	digestion	digestion	NOUN
admet-830	173	9	and	and	CCONJ
admet-830	173	10	increase	increase	VERB
admet-830	173	11	the	the	DET
admet-830	173	12	concentration	concentration	NOUN
admet-830	173	13	of	of	ADP
admet-830	173	14	fatty	fatty	NOUN
admet-830	173	15	acid	acid	NOUN
admet-830	173	16	-	-	PUNCT
admet-830	173	17	rich	rich	ADJ
admet-830	173	18	solubilising	solubilising	NOUN
admet-830	173	19	vesicles	vesicle	NOUN
admet-830	173	20	within	within	ADP
admet-830	173	21	the	the	DET
admet-830	173	22	aqueous	aqueous	ADJ
admet-830	173	23	phase	phase	NOUN
admet-830	173	24	are	be	AUX
admet-830	173	25	therefore	therefore	ADV
admet-830	173	26	considered	consider	VERB
admet-830	173	27	the	the	DET
admet-830	173	28	driving	drive	VERB
admet-830	173	29	force	force	NOUN
admet-830	173	30	for	for	ADP
admet-830	173	31	improved	improved	ADJ
admet-830	173	32	lur	lur	PROPN
admet-830	173	33	solubilisation	solubilisation	NOUN
admet-830	173	34	,	,	PUNCT
admet-830	173	35	when	when	SCONJ
admet-830	173	36	compared	compare	VERB
admet-830	173	37	the	the	DET
admet-830	173	38	lur	lur	PROPN
admet-830	173	39	emulsion	emulsion	NOUN
admet-830	173	40	.	.	PUNCT
admet-830	174	1	drug	drug	NOUN
admet-830	174	2	precipitation	precipitation	NOUN
admet-830	174	3	is	be	AUX
admet-830	174	4	commonly	commonly	ADV
admet-830	174	5	observed	observe	VERB
admet-830	174	6	with	with	ADP
admet-830	174	7	lbfs	lbfs	NOUN
admet-830	174	8	[	[	X
admet-830	174	9	28	28	NUM
admet-830	174	10	,	,	PUNCT
admet-830	174	11	29	29	NUM
admet-830	174	12	]	]	PUNCT
admet-830	174	13	.	.	PUNCT
admet-830	175	1	upon	upon	SCONJ
admet-830	175	2	digestion	digestion	NOUN
admet-830	175	3	of	of	ADP
admet-830	175	4	the	the	DET
admet-830	175	5	exogenous	exogenous	ADJ
admet-830	175	6	lipid	lipid	NOUN
admet-830	175	7	,	,	PUNCT
admet-830	175	8	the	the	DET
admet-830	175	9	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	175	10	admet	admet	PROPN
admet-830	175	11	&	&	CCONJ
admet-830	175	12	dmpk	dmpk	PROPN
admet-830	175	13	8(4	8(4	NOUN
admet-830	175	14	)	)	PUNCT
admet-830	175	15	(	(	PUNCT
admet-830	175	16	2020	2020	NUM
admet-830	175	17	)	)	PUNCT
admet-830	175	18	437	437	NUM
admet-830	175	19	-	-	SYM
admet-830	175	20	451	451	NUM
admet-830	175	21	drug	drug	NOUN
admet-830	175	22	ionisation	ionisation	NOUN
admet-830	175	23	and	and	CCONJ
admet-830	175	24	lipid	lipid	NOUN
admet-830	175	25	-	-	PUNCT
admet-830	175	26	based	base	VERB
admet-830	175	27	formulations	formulation	NOUN
admet-830	175	28	doi	doi	NOUN
admet-830	175	29	:	:	PUNCT
admet-830	175	30	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	175	31	446	446	NUM
admet-830	175	32	solubilisation	solubilisation	NOUN
admet-830	175	33	capacity	capacity	NOUN
admet-830	175	34	for	for	ADP
admet-830	175	35	the	the	DET
admet-830	175	36	drug	drug	NOUN
admet-830	175	37	is	be	AUX
admet-830	175	38	enhanced	enhance	VERB
admet-830	175	39	and	and	CCONJ
admet-830	175	40	thus	thus	ADV
admet-830	175	41	supersaturated	supersaturated	ADJ
admet-830	175	42	drug	drug	NOUN
admet-830	175	43	concentrations	concentration	NOUN
admet-830	175	44	may	may	AUX
admet-830	175	45	be	be	AUX
admet-830	175	46	generated	generate	VERB
admet-830	176	1	[	[	PUNCT
admet-830	176	2	30	30	NUM
admet-830	176	3	]	]	PUNCT
admet-830	176	4	.	.	PUNCT
admet-830	177	1	the	the	DET
admet-830	177	2	current	current	ADJ
admet-830	177	3	solubilisation	solubilisation	NOUN
admet-830	177	4	study	study	NOUN
admet-830	177	5	was	be	AUX
admet-830	177	6	conducted	conduct	VERB
admet-830	177	7	in	in	ADP
admet-830	177	8	non	non	ADJ
admet-830	177	9	-	-	ADJ
admet-830	177	10	sink	sink	ADJ
admet-830	177	11	conditions	condition	NOUN
admet-830	177	12	and	and	CCONJ
admet-830	177	13	thus	thus	ADV
admet-830	177	14	the	the	DET
admet-830	177	15	lack	lack	NOUN
admet-830	177	16	of	of	ADP
admet-830	177	17	solubilising	solubilise	VERB
admet-830	177	18	capacity	capacity	NOUN
admet-830	177	19	of	of	ADP
admet-830	177	20	the	the	DET
admet-830	177	21	aqueous	aqueous	ADJ
admet-830	177	22	phase	phase	NOUN
admet-830	177	23	resulted	result	VERB
admet-830	177	24	in	in	ADP
admet-830	177	25	rapid	rapid	ADJ
admet-830	177	26	drug	drug	NOUN
admet-830	177	27	precipitation	precipitation	NOUN
admet-830	177	28	from	from	ADP
admet-830	177	29	lbfs	lbfs	NOUN
admet-830	177	30	,	,	PUNCT
admet-830	177	31	as	as	ADP
admet-830	177	32	evident	evident	ADJ
admet-830	177	33	within	within	ADP
admet-830	177	34	the	the	DET
admet-830	177	35	initial	initial	ADJ
admet-830	177	36	10	10	NUM
admet-830	177	37	min	min	NOUN
admet-830	177	38	of	of	ADP
admet-830	177	39	solubilisation	solubilisation	NOUN
admet-830	177	40	(	(	PUNCT
admet-830	177	41	figure	figure	VERB
admet-830	177	42	6a	6a	NOUN
admet-830	177	43	)	)	PUNCT
admet-830	177	44	.	.	PUNCT
admet-830	178	1	however	however	ADV
admet-830	178	2	,	,	PUNCT
admet-830	178	3	precipitation	precipitation	NOUN
admet-830	178	4	during	during	ADP
admet-830	178	5	in	in	ADP
admet-830	178	6	vitro	vitro	X
admet-830	178	7	studies	study	NOUN
admet-830	178	8	does	do	AUX
admet-830	178	9	not	not	PART
admet-830	178	10	necessarily	necessarily	ADV
admet-830	178	11	correlate	correlate	VERB
admet-830	178	12	with	with	ADP
admet-830	178	13	a	a	DET
admet-830	178	14	reduction	reduction	NOUN
admet-830	178	15	in	in	ADP
admet-830	178	16	bioavailability	bioavailability	NOUN
admet-830	178	17	in	in	ADP
admet-830	178	18	vivo	vivo	NOUN
admet-830	178	19	,	,	PUNCT
admet-830	178	20	as	as	SCONJ
admet-830	178	21	many	many	ADJ
admet-830	178	22	studies	study	NOUN
admet-830	178	23	suggests	suggest	VERB
admet-830	178	24	that	that	SCONJ
admet-830	178	25	this	this	DET
admet-830	178	26	model	model	NOUN
admet-830	178	27	over	over	ADP
admet-830	178	28	predicts	predict	NOUN
admet-830	178	29	the	the	DET
admet-830	178	30	extent	extent	NOUN
admet-830	178	31	of	of	ADP
admet-830	178	32	drug	drug	NOUN
admet-830	178	33	precipitation	precipitation	NOUN
admet-830	178	34	due	due	ADP
admet-830	178	35	to	to	ADP
admet-830	178	36	the	the	DET
admet-830	178	37	absence	absence	NOUN
admet-830	178	38	of	of	ADP
admet-830	178	39	an	an	DET
admet-830	178	40	absorption	absorption	NOUN
admet-830	178	41	compartment	compartment	NOUN
admet-830	178	42	[	[	X
admet-830	178	43	31	31	NUM
admet-830	178	44	,	,	PUNCT
admet-830	178	45	32	32	NUM
admet-830	178	46	]	]	PUNCT
admet-830	178	47	.	.	PUNCT
admet-830	179	1	impact	impact	NOUN
admet-830	179	2	of	of	ADP
admet-830	179	3	ris	ris	PROPN
admet-830	179	4	reformulation	reformulation	PROPN
admet-830	179	5	on	on	ADP
admet-830	179	6	lipolysis	lipolysis	NOUN
admet-830	179	7	and	and	CCONJ
admet-830	179	8	drug	drug	NOUN
admet-830	179	9	solubilisation	solubilisation	NOUN
admet-830	179	10	in	in	ADP
admet-830	179	11	contrast	contrast	NOUN
admet-830	179	12	to	to	ADP
admet-830	179	13	lur	lur	PROPN
admet-830	179	14	,	,	PUNCT
admet-830	179	15	pure	pure	ADJ
admet-830	179	16	ris	ris	PROPN
admet-830	179	17	displayed	display	VERB
admet-830	179	18	the	the	DET
admet-830	179	19	greatest	great	ADJ
admet-830	179	20	level	level	NOUN
admet-830	179	21	of	of	ADP
admet-830	179	22	drug	drug	NOUN
admet-830	179	23	solubilisation	solubilisation	NOUN
admet-830	179	24	under	under	ADP
admet-830	179	25	digesting	digest	VERB
admet-830	179	26	conditions	condition	NOUN
admet-830	179	27	,	,	PUNCT
admet-830	179	28	reaching	reach	VERB
admet-830	179	29	a	a	DET
admet-830	179	30	maximum	maximum	NOUN
admet-830	179	31	of	of	ADP
admet-830	179	32	93.4	93.4	NUM
admet-830	179	33	±	±	NUM
admet-830	179	34	5.3	5.3	NUM
admet-830	179	35	%	%	NOUN
admet-830	179	36	(	(	PUNCT
admet-830	179	37	254	254	NUM
admet-830	179	38	µg	µg	NOUN
admet-830	179	39	/	/	SYM
admet-830	179	40	ml	ml	NOUN
admet-830	179	41	)	)	PUNCT
admet-830	179	42	after	after	ADP
admet-830	179	43	60	60	NUM
admet-830	179	44	min	min	NOUN
admet-830	179	45	,	,	PUNCT
admet-830	179	46	followed	follow	VERB
admet-830	179	47	by	by	ADP
admet-830	179	48	the	the	DET
admet-830	179	49	ris	ris	PROPN
admet-830	179	50	emulsion	emulsion	NOUN
admet-830	179	51	and	and	CCONJ
admet-830	179	52	ris	ris	PROPN
admet-830	179	53	-	-	PROPN
admet-830	179	54	slh	slh	PROPN
admet-830	179	55	(	(	PUNCT
admet-830	179	56	figure	figure	NOUN
admet-830	179	57	7a	7a	NUM
admet-830	179	58	)	)	PUNCT
admet-830	179	59	.	.	PUNCT
admet-830	180	1	the	the	DET
admet-830	180	2	drug	drug	NOUN
admet-830	180	3	solubilisation	solubilisation	NOUN
admet-830	180	4	observed	observe	VERB
admet-830	180	5	for	for	ADP
admet-830	180	6	pure	pure	ADJ
admet-830	180	7	ris	ris	PROPN
admet-830	180	8	is	be	AUX
admet-830	180	9	indicative	indicative	ADJ
admet-830	180	10	of	of	ADP
admet-830	180	11	the	the	DET
admet-830	180	12	high	high	ADJ
admet-830	180	13	solubility	solubility	NOUN
admet-830	180	14	of	of	ADP
admet-830	180	15	the	the	DET
admet-830	180	16	ionised	ionised	ADJ
admet-830	180	17	drug	drug	NOUN
admet-830	180	18	in	in	ADP
admet-830	180	19	neutral	neutral	ADJ
admet-830	180	20	conditions	condition	NOUN
admet-830	180	21	.	.	PUNCT
admet-830	181	1	a	a	DET
admet-830	181	2	drug	drug	NOUN
admet-830	181	3	solubilisation	solubilisation	NOUN
admet-830	181	4	level	level	NOUN
admet-830	181	5	of	of	ADP
admet-830	181	6	80.5	80.5	NUM
admet-830	181	7	±	±	NUM
admet-830	181	8	0.8	0.8	NUM
admet-830	181	9	%	%	NOUN
admet-830	181	10	(	(	PUNCT
admet-830	181	11	209	209	NUM
admet-830	181	12	µg	µg	NOUN
admet-830	181	13	/	/	SYM
admet-830	181	14	ml	ml	NOUN
admet-830	181	15	)	)	PUNCT
admet-830	181	16	,	,	PUNCT
admet-830	181	17	was	be	AUX
admet-830	181	18	observed	observe	VERB
admet-830	181	19	for	for	ADP
admet-830	181	20	the	the	DET
admet-830	181	21	ris	ris	PROPN
admet-830	181	22	emulsion	emulsion	NOUN
admet-830	181	23	,	,	PUNCT
admet-830	181	24	likely	likely	ADV
admet-830	181	25	owing	owe	VERB
admet-830	181	26	to	to	ADP
admet-830	181	27	incomplete	incomplete	ADJ
admet-830	181	28	digestion	digestion	NOUN
admet-830	181	29	of	of	ADP
admet-830	181	30	the	the	DET
admet-830	181	31	lipid	lipid	NOUN
admet-830	181	32	and	and	CCONJ
admet-830	181	33	thus	thus	ADV
admet-830	181	34	,	,	PUNCT
admet-830	181	35	only	only	ADJ
admet-830	181	36	partial	partial	ADJ
admet-830	181	37	drug	drug	NOUN
admet-830	181	38	partitioning	partition	VERB
admet-830	181	39	to	to	ADP
admet-830	181	40	the	the	DET
admet-830	181	41	aqueous	aqueous	ADJ
admet-830	181	42	phase	phase	NOUN
admet-830	181	43	.	.	PUNCT
admet-830	182	1	however	however	ADV
admet-830	182	2	,	,	PUNCT
admet-830	182	3	it	it	PRON
admet-830	182	4	is	be	AUX
admet-830	182	5	noteworthy	noteworthy	ADJ
admet-830	182	6	that	that	SCONJ
admet-830	182	7	the	the	DET
admet-830	182	8	performance	performance	NOUN
admet-830	182	9	of	of	ADP
admet-830	182	10	the	the	DET
admet-830	182	11	ris	ris	PROPN
admet-830	182	12	emulsion	emulsion	NOUN
admet-830	182	13	,	,	PUNCT
admet-830	182	14	relative	relative	ADJ
admet-830	182	15	to	to	ADP
admet-830	182	16	pure	pure	ADJ
admet-830	182	17	drug	drug	NOUN
admet-830	182	18	,	,	PUNCT
admet-830	182	19	was	be	AUX
admet-830	182	20	significantly	significantly	ADV
admet-830	182	21	greater	great	ADJ
admet-830	182	22	during	during	ADP
admet-830	182	23	solubilisation	solubilisation	NOUN
admet-830	182	24	studies	study	NOUN
admet-830	182	25	under	under	ADP
admet-830	182	26	digestion	digestion	NOUN
admet-830	182	27	conditions	condition	NOUN
admet-830	182	28	compared	compare	VERB
admet-830	182	29	to	to	ADP
admet-830	182	30	non	non	ADJ
admet-830	182	31	-	-	ADJ
admet-830	182	32	digesting	digesting	ADJ
admet-830	182	33	conditions	condition	NOUN
admet-830	182	34	,	,	PUNCT
admet-830	182	35	indicating	indicate	VERB
admet-830	182	36	the	the	DET
admet-830	182	37	importance	importance	NOUN
admet-830	182	38	of	of	ADP
admet-830	182	39	lipase	lipase	NOUN
admet-830	182	40	-	-	PUNCT
admet-830	182	41	provoked	provoke	VERB
admet-830	182	42	drug	drug	NOUN
admet-830	182	43	release	release	NOUN
admet-830	182	44	.	.	PUNCT
admet-830	183	1	however	however	ADV
admet-830	183	2	,	,	PUNCT
admet-830	183	3	for	for	ADP
admet-830	183	4	ris	ris	PROPN
admet-830	183	5	-	-	NOUN
admet-830	183	6	slh	slh	PROPN
admet-830	183	7	,	,	PUNCT
admet-830	183	8	a	a	DET
admet-830	183	9	significant	significant	ADJ
admet-830	183	10	2.2	2.2	NUM
admet-830	183	11	-	-	ADJ
admet-830	183	12	fold	fold	ADJ
admet-830	183	13	reduction	reduction	NOUN
admet-830	183	14	in	in	ADP
admet-830	183	15	solubilisation	solubilisation	NOUN
admet-830	183	16	was	be	AUX
admet-830	183	17	evident	evident	ADJ
admet-830	183	18	,	,	PUNCT
admet-830	183	19	leading	lead	VERB
admet-830	183	20	to	to	ADP
admet-830	183	21	a	a	DET
admet-830	183	22	ris	ris	X
admet-830	183	23	solubilisation	solubilisation	NOUN
admet-830	183	24	of	of	ADP
admet-830	183	25	only	only	ADV
admet-830	183	26	43.2	43.2	NUM
admet-830	183	27	±	±	NUM
admet-830	183	28	2.2	2.2	NUM
admet-830	183	29	%	%	NOUN
admet-830	183	30	(	(	PUNCT
admet-830	183	31	109	109	NUM
admet-830	183	32	µg	µg	NOUN
admet-830	183	33	/	/	SYM
admet-830	183	34	ml	ml	NOUN
admet-830	183	35	)	)	PUNCT
admet-830	183	36	after	after	ADP
admet-830	183	37	60	60	NUM
admet-830	183	38	min	min	NOUN
admet-830	183	39	.	.	PROPN
admet-830	183	40	figure	figure	NOUN
admet-830	183	41	7	7	NUM
admet-830	183	42	.	.	PUNCT
admet-830	184	1	(	(	PUNCT
admet-830	184	2	a	a	X
admet-830	184	3	)	)	PUNCT
admet-830	184	4	in	in	ADP
admet-830	184	5	vitro	vitro	X
admet-830	184	6	solubilisation	solubilisation	NOUN
admet-830	184	7	profiles	profile	NOUN
admet-830	184	8	under	under	ADP
admet-830	184	9	digesting	digest	VERB
admet-830	184	10	conditions	condition	NOUN
admet-830	184	11	,	,	PUNCT
admet-830	184	12	and	and	CCONJ
admet-830	184	13	(	(	PUNCT
admet-830	184	14	b	b	NOUN
admet-830	184	15	)	)	PUNCT
admet-830	184	16	lipolysis	lipolysis	NOUN
admet-830	184	17	data	datum	NOUN
admet-830	184	18	for	for	ADP
admet-830	184	19	pure	pure	ADJ
admet-830	184	20	ris	ris	X
admet-830	185	1	[	[	X
admet-830	185	2	▲	▲	PUNCT
admet-830	185	3	]	]	X
admet-830	185	4	,	,	PUNCT
admet-830	185	5	ris	ris	X
admet-830	185	6	emulsion	emulsion	NOUN
admet-830	185	7	[	[	X
admet-830	185	8	◆	◆	NOUN
admet-830	185	9	]	]	X
admet-830	185	10	,	,	PUNCT
admet-830	185	11	and	and	CCONJ
admet-830	185	12	ris	ris	PROPN
admet-830	185	13	-	-	ADJ
admet-830	185	14	slh	slh	NOUN
admet-830	185	15	[	[	X
admet-830	185	16	✕	✕	NOUN
admet-830	185	17	]	]	X
admet-830	185	18	.	.	PUNCT
admet-830	186	1	each	each	DET
admet-830	186	2	value	value	NOUN
admet-830	186	3	represents	represent	VERB
admet-830	186	4	the	the	DET
admet-830	186	5	mean	mean	ADJ
admet-830	186	6	±	±	NUM
admet-830	186	7	sd	sd	NOUN
admet-830	186	8	,	,	PUNCT
admet-830	186	9	n	n	NOUN
admet-830	186	10	=	=	SYM
admet-830	186	11	3	3	X
admet-830	186	12	.	.	PUNCT
admet-830	187	1	the	the	DET
admet-830	187	2	reduced	reduce	VERB
admet-830	187	3	ability	ability	NOUN
admet-830	187	4	for	for	ADP
admet-830	187	5	ris	ris	PROPN
admet-830	187	6	-	-	ADJ
admet-830	187	7	slh	slh	NOUN
admet-830	187	8	to	to	PART
admet-830	187	9	promote	promote	VERB
admet-830	187	10	solubilisation	solubilisation	NOUN
admet-830	187	11	under	under	ADP
admet-830	187	12	digesting	digest	VERB
admet-830	187	13	conditions	condition	NOUN
admet-830	187	14	can	can	AUX
admet-830	187	15	be	be	AUX
admet-830	187	16	attributed	attribute	VERB
admet-830	187	17	a	a	DET
admet-830	187	18	reduction	reduction	NOUN
admet-830	187	19	in	in	ADP
admet-830	187	20	lipolysis	lipolysis	NOUN
admet-830	187	21	kinetics	kinetic	NOUN
admet-830	187	22	and	and	CCONJ
admet-830	187	23	the	the	DET
admet-830	187	24	interaction	interaction	NOUN
admet-830	187	25	between	between	ADP
admet-830	187	26	the	the	DET
admet-830	187	27	ionised	ionised	ADJ
admet-830	187	28	drug	drug	NOUN
admet-830	187	29	and	and	CCONJ
admet-830	187	30	the	the	DET
admet-830	187	31	negatively	negatively	ADV
admet-830	187	32	charged	charge	VERB
admet-830	187	33	silica	silica	NOUN
admet-830	187	34	surfaces	surface	NOUN
admet-830	187	35	and	and	CCONJ
admet-830	187	36	fatty	fatty	NOUN
admet-830	187	37	acids	acid	NOUN
admet-830	187	38	produced	produce	VERB
admet-830	187	39	during	during	ADP
admet-830	187	40	digestion	digestion	NOUN
admet-830	187	41	.	.	PUNCT
admet-830	188	1	in	in	ADP
admet-830	188	2	contrary	contrary	ADJ
admet-830	188	3	to	to	ADP
admet-830	188	4	the	the	DET
admet-830	188	5	lipid	lipid	NOUN
admet-830	188	6	digestion	digestion	NOUN
admet-830	188	7	observed	observe	VERB
admet-830	188	8	for	for	ADP
admet-830	188	9	lur	lur	PROPN
admet-830	188	10	lbfs	lbfs	NOUN
admet-830	188	11	,	,	PUNCT
admet-830	188	12	the	the	DET
admet-830	188	13	rate	rate	NOUN
admet-830	188	14	and	and	CCONJ
admet-830	188	15	extent	extent	NOUN
admet-830	188	16	of	of	ADP
admet-830	188	17	lipolysis	lipolysis	NOUN
admet-830	188	18	was	be	AUX
admet-830	188	19	greatest	great	ADJ
admet-830	188	20	for	for	ADP
admet-830	188	21	the	the	DET
admet-830	188	22	ris	ris	PROPN
admet-830	188	23	emulsion	emulsion	NOUN
admet-830	188	24	,	,	PUNCT
admet-830	188	25	with	with	ADP
admet-830	188	26	34.9	34.9	NUM
admet-830	188	27	±	±	NUM
admet-830	188	28	0.3	0.3	NUM
admet-830	188	29	%	%	NOUN
admet-830	188	30	lipid	lipid	NOUN
admet-830	188	31	being	be	AUX
admet-830	188	32	digested	digest	VERB
admet-830	188	33	over	over	ADP
admet-830	188	34	the	the	DET
admet-830	188	35	60	60	NUM
admet-830	188	36	min	min	NOUN
admet-830	188	37	period	period	NOUN
admet-830	188	38	,	,	PUNCT
admet-830	188	39	compared	compare	VERB
admet-830	188	40	to	to	ADP
admet-830	188	41	only	only	ADV
admet-830	188	42	30.2	30.2	NUM
admet-830	188	43	±	±	NUM
admet-830	188	44	0.4	0.4	NUM
admet-830	188	45	%	%	NOUN
admet-830	188	46	for	for	ADP
admet-830	188	47	ris	ris	PROPN
admet-830	188	48	-	-	ADJ
admet-830	188	49	slh	slh	PROPN
admet-830	188	50	(	(	PUNCT
admet-830	188	51	figure	figure	NOUN
admet-830	188	52	7b	7b	NUM
admet-830	188	53	)	)	PUNCT
admet-830	188	54	.	.	PUNCT
admet-830	189	1	the	the	DET
admet-830	189	2	difference	difference	NOUN
admet-830	189	3	in	in	ADP
admet-830	189	4	lipolysis	lipolysis	NOUN
admet-830	189	5	behaviour	behaviour	NOUN
admet-830	189	6	between	between	ADP
admet-830	189	7	the	the	DET
admet-830	189	8	two	two	NUM
admet-830	189	9	drugs	drug	NOUN
admet-830	189	10	,	,	PUNCT
admet-830	189	11	when	when	SCONJ
admet-830	189	12	encapsulated	encapsulate	VERB
admet-830	189	13	within	within	ADP
admet-830	189	14	slh	slh	PROPN
admet-830	189	15	,	,	PUNCT
admet-830	189	16	is	be	AUX
admet-830	189	17	due	due	ADJ
admet-830	189	18	to	to	ADP
admet-830	189	19	the	the	DET
admet-830	189	20	relative	relative	ADJ
admet-830	189	21	degrees	degree	NOUN
admet-830	189	22	of	of	ADP
admet-830	189	23	ionisation	ionisation	NOUN
admet-830	189	24	,	,	PUNCT
admet-830	189	25	where	where	SCONJ
admet-830	189	26	ris	ris	PROPN
admet-830	189	27	is	be	AUX
admet-830	189	28	mostly	mostly	ADV
admet-830	189	29	present	present	ADJ
admet-830	189	30	in	in	ADP
admet-830	189	31	its	its	PRON
admet-830	189	32	ionised	ionise	VERB
admet-830	189	33	,	,	PUNCT
admet-830	189	34	positively	positively	ADV
admet-830	189	35	charged	charge	VERB
admet-830	189	36	form	form	NOUN
admet-830	189	37	.	.	PUNCT
admet-830	190	1	since	since	SCONJ
admet-830	190	2	the	the	DET
admet-830	190	3	porous	porous	ADJ
admet-830	190	4	silica	silica	NOUN
admet-830	190	5	matrix	matrix	NOUN
admet-830	190	6	and	and	CCONJ
admet-830	190	7	the	the	DET
admet-830	190	8	fatty	fatty	NOUN
admet-830	190	9	acids	acid	NOUN
admet-830	190	10	produced	produce	VERB
admet-830	190	11	from	from	ADP
admet-830	190	12	lipolysis	lipolysis	NOUN
admet-830	190	13	are	be	AUX
admet-830	190	14	both	both	PRON
admet-830	190	15	negatively	negatively	ADV
admet-830	190	16	charged	charge	VERB
admet-830	190	17	,	,	PUNCT
admet-830	190	18	complexation	complexation	NOUN
admet-830	190	19	occurs	occur	VERB
admet-830	190	20	between	between	ADP
admet-830	190	21	ionised	ionised	ADJ
admet-830	190	22	ris	ris	PROPN
admet-830	190	23	and	and	CCONJ
admet-830	190	24	both	both	DET
admet-830	190	25	the	the	DET
admet-830	190	26	silica	silica	NOUN
admet-830	190	27	surface	surface	NOUN
admet-830	190	28	and	and	CCONJ
admet-830	190	29	lipid	lipid	NOUN
admet-830	190	30	digestion	digestion	NOUN
admet-830	190	31	products	product	NOUN
admet-830	190	32	,	,	PUNCT
admet-830	190	33	as	as	SCONJ
admet-830	190	34	depicted	depict	VERB
admet-830	190	35	in	in	ADP
admet-830	190	36	figure	figure	NOUN
admet-830	190	37	8	8	NUM
admet-830	190	38	.	.	PUNCT
admet-830	191	1	this	this	DET
admet-830	191	2	interaction	interaction	NOUN
admet-830	191	3	was	be	AUX
admet-830	191	4	confirmed	confirm	VERB
admet-830	191	5	by	by	ADP
admet-830	191	6	analysing	analyse	VERB
admet-830	191	7	the	the	DET
admet-830	191	8	zeta	zeta	NOUN
admet-830	191	9	potential	potential	NOUN
admet-830	191	10	of	of	ADP
admet-830	191	11	the	the	DET
admet-830	191	12	various	various	ADJ
admet-830	191	13	silica	silica	NOUN
admet-830	191	14	:	:	PUNCT
admet-830	191	15	drug	drug	NOUN
admet-830	191	16	:	:	PUNCT
admet-830	191	17	fatty	fatty	NOUN
admet-830	191	18	acid	acid	NOUN
admet-830	191	19	complexes	complex	NOUN
admet-830	191	20	that	that	PRON
admet-830	191	21	are	be	AUX
admet-830	191	22	predicted	predict	VERB
admet-830	191	23	to	to	PART
admet-830	191	24	form	form	VERB
admet-830	191	25	during	during	ADP
admet-830	191	26	lipase	lipase	NOUN
admet-830	191	27	-	-	PUNCT
admet-830	191	28	mediated	mediate	VERB
admet-830	191	29	digestion	digestion	NOUN
admet-830	191	30	of	of	ADP
admet-830	191	31	both	both	PRON
admet-830	191	32	lurand	lurand	PROPN
admet-830	192	1	ris	ris	PROPN
admet-830	192	2	-	-	PROPN
admet-830	192	3	slh	slh	PROPN
admet-830	192	4	(	(	PUNCT
admet-830	192	5	table	table	NOUN
admet-830	192	6	2	2	NUM
admet-830	192	7	)	)	PUNCT
admet-830	192	8	.	.	PUNCT
admet-830	193	1	when	when	SCONJ
admet-830	193	2	porous	porous	ADJ
admet-830	193	3	silica	silica	NOUN
admet-830	193	4	particles	particle	NOUN
admet-830	193	5	were	be	AUX
admet-830	193	6	spiked	spike	VERB
admet-830	193	7	with	with	ADP
admet-830	193	8	dissolved	dissolved	ADJ
admet-830	193	9	ris	ris	PROPN
admet-830	193	10	,	,	PUNCT
admet-830	193	11	the	the	DET
admet-830	193	12	zeta	zeta	NOUN
admet-830	193	13	potential	potential	NOUN
admet-830	193	14	increased	increase	VERB
admet-830	193	15	from	from	ADP
admet-830	193	16	-19.1	-19.1	PROPN
admet-830	193	17	±	±	PROPN
admet-830	193	18	2.7	2.7	NUM
admet-830	193	19	mv	mv	NOUN
admet-830	193	20	to	to	ADP
admet-830	193	21	-12.3	-12.3	PROPN
admet-830	193	22	±	±	NUM
admet-830	193	23	0.8	0.8	NUM
admet-830	193	24	mv	mv	PROPN
admet-830	193	25	,	,	PUNCT
admet-830	193	26	highlighting	highlight	VERB
admet-830	193	27	the	the	DET
admet-830	193	28	capacity	capacity	NOUN
admet-830	193	29	for	for	ADP
admet-830	193	30	ionised	ionised	ADJ
admet-830	193	31	ris	ris	PROPN
admet-830	193	32	to	to	PART
admet-830	193	33	adsorb	adsorb	VERB
admet-830	193	34	to	to	ADP
admet-830	193	35	the	the	DET
admet-830	193	36	negatively	negatively	ADV
admet-830	193	37	charged	charge	VERB
admet-830	193	38	silica	silica	NOUN
admet-830	193	39	surface	surface	NOUN
admet-830	193	40	.	.	PUNCT
admet-830	194	1	however	however	ADV
admet-830	194	2	,	,	PUNCT
admet-830	194	3	once	once	ADV
admet-830	194	4	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	194	5	admet	admet	PROPN
admet-830	194	6	&	&	CCONJ
admet-830	194	7	dmpk	dmpk	PROPN
admet-830	194	8	8(4	8(4	NOUN
admet-830	194	9	)	)	PUNCT
admet-830	194	10	(	(	PUNCT
admet-830	194	11	2020	2020	NUM
admet-830	194	12	)	)	PUNCT
admet-830	194	13	437	437	NUM
admet-830	194	14	-	-	SYM
admet-830	194	15	451	451	NUM
admet-830	194	16	drug	drug	NOUN
admet-830	194	17	ionisation	ionisation	NOUN
admet-830	194	18	and	and	CCONJ
admet-830	194	19	lipid	lipid	NOUN
admet-830	194	20	-	-	PUNCT
admet-830	194	21	based	base	VERB
admet-830	194	22	formulations	formulation	NOUN
admet-830	194	23	doi	doi	NOUN
admet-830	194	24	:	:	PUNCT
admet-830	194	25	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	194	26	447	447	NUM
admet-830	194	27	the	the	DET
admet-830	194	28	silica	silica	NOUN
admet-830	194	29	:	:	PUNCT
admet-830	194	30	ris	ris	PROPN
admet-830	194	31	complex	complex	NOUN
admet-830	194	32	was	be	AUX
admet-830	194	33	exposed	expose	VERB
admet-830	194	34	to	to	ADP
admet-830	194	35	fatty	fatty	NOUN
admet-830	194	36	acids	acid	NOUN
admet-830	194	37	,	,	PUNCT
admet-830	194	38	representative	representative	NOUN
admet-830	194	39	of	of	ADP
admet-830	194	40	those	those	PRON
admet-830	194	41	present	present	ADJ
admet-830	194	42	during	during	ADP
admet-830	194	43	in	in	ADP
admet-830	194	44	vitro	vitro	X
admet-830	194	45	lipolysis	lipolysis	NOUN
admet-830	194	46	(	(	PUNCT
admet-830	194	47	i.e.	i.e.	X
admet-830	194	48	medium	medium	ADJ
admet-830	194	49	chain	chain	NOUN
admet-830	194	50	length	length	NOUN
admet-830	194	51	fatty	fatty	NOUN
admet-830	194	52	acids	acid	NOUN
admet-830	194	53	)	)	PUNCT
admet-830	194	54	,	,	PUNCT
admet-830	194	55	the	the	DET
admet-830	194	56	zeta	zeta	PROPN
admet-830	194	57	potential	potential	NOUN
admet-830	194	58	again	again	ADV
admet-830	194	59	decreased	decrease	VERB
admet-830	194	60	to	to	ADP
admet-830	194	61	-15.0	-15.0	PUNCT
admet-830	194	62	±	±	NUM
admet-830	194	63	0.3	0.3	NUM
admet-830	194	64	mv	mv	PROPN
admet-830	194	65	,	,	PUNCT
admet-830	194	66	indicating	indicate	VERB
admet-830	194	67	the	the	DET
admet-830	194	68	propensity	propensity	NOUN
admet-830	194	69	for	for	ADP
admet-830	194	70	negatively	negatively	ADV
admet-830	194	71	charged	charge	VERB
admet-830	194	72	fatty	fatty	NOUN
admet-830	194	73	acids	acid	NOUN
admet-830	194	74	to	to	PART
admet-830	194	75	adsorb	adsorb	VERB
admet-830	194	76	onto	onto	ADP
admet-830	194	77	the	the	DET
admet-830	194	78	ris	ris	PROPN
admet-830	194	79	-	-	ADJ
admet-830	194	80	coated	coat	VERB
admet-830	194	81	silica	silica	NOUN
admet-830	194	82	surface	surface	NOUN
admet-830	194	83	through	through	ADP
admet-830	194	84	electrostatic	electrostatic	ADJ
admet-830	194	85	interactions	interaction	NOUN
admet-830	194	86	.	.	PUNCT
admet-830	195	1	in	in	ADP
admet-830	195	2	contrast	contrast	NOUN
admet-830	195	3	,	,	PUNCT
admet-830	195	4	zeta	zeta	NOUN
admet-830	195	5	potential	potential	ADJ
admet-830	195	6	variations	variation	NOUN
admet-830	195	7	when	when	SCONJ
admet-830	195	8	porous	porous	ADJ
admet-830	195	9	silica	silica	NOUN
admet-830	195	10	particles	particle	NOUN
admet-830	195	11	were	be	AUX
admet-830	195	12	exposed	expose	VERB
admet-830	195	13	to	to	ADP
admet-830	195	14	lur	lur	PROPN
admet-830	195	15	were	be	AUX
admet-830	195	16	statistically	statistically	ADV
admet-830	195	17	insignificant	insignificant	ADJ
admet-830	195	18	;	;	PUNCT
admet-830	195	19	thus	thus	ADV
admet-830	195	20	,	,	PUNCT
admet-830	195	21	highlighting	highlight	VERB
admet-830	195	22	the	the	DET
admet-830	195	23	ability	ability	NOUN
admet-830	195	24	for	for	ADP
admet-830	195	25	lur	lur	NOUN
admet-830	195	26	and	and	CCONJ
admet-830	195	27	negatively	negatively	ADV
admet-830	195	28	charged	charge	VERB
admet-830	195	29	fatty	fatty	NOUN
admet-830	195	30	acids	acid	NOUN
admet-830	195	31	to	to	PART
admet-830	195	32	be	be	AUX
admet-830	195	33	repelled	repel	VERB
admet-830	195	34	from	from	ADP
admet-830	195	35	the	the	DET
admet-830	195	36	bare	bare	ADJ
admet-830	195	37	silica	silica	NOUN
admet-830	195	38	surface	surface	NOUN
admet-830	195	39	(	(	PUNCT
admet-830	195	40	table	table	NOUN
admet-830	195	41	2	2	NUM
admet-830	195	42	)	)	PUNCT
admet-830	195	43	.	.	PUNCT
admet-830	196	1	figure	figure	VERB
admet-830	196	2	8	8	NUM
admet-830	196	3	.	.	PUNCT
admet-830	197	1	schematic	schematic	ADJ
admet-830	197	2	representation	representation	NOUN
admet-830	197	3	showing	show	VERB
admet-830	197	4	the	the	DET
admet-830	197	5	difference	difference	NOUN
admet-830	197	6	in	in	ADP
admet-830	197	7	lur	lur	PROPN
admet-830	197	8	and	and	CCONJ
admet-830	197	9	ris	ris	PROPN
admet-830	197	10	solubilisation	solubilisation	NOUN
admet-830	197	11	when	when	SCONJ
admet-830	197	12	encapsulated	encapsulate	VERB
admet-830	197	13	within	within	ADP
admet-830	197	14	slh	slh	ADJ
admet-830	197	15	microparticles	microparticle	NOUN
admet-830	197	16	.	.	PUNCT
admet-830	198	1	at	at	ADP
admet-830	198	2	neutral	neutral	ADJ
admet-830	198	3	ph	ph	PROPN
admet-830	198	4	,	,	PUNCT
admet-830	198	5	ris	ris	PROPN
admet-830	198	6	is	be	AUX
admet-830	198	7	predominately	predominately	ADV
admet-830	198	8	ionised	ionise	VERB
admet-830	198	9	and	and	CCONJ
admet-830	198	10	carries	carry	VERB
admet-830	198	11	a	a	DET
admet-830	198	12	positive	positive	ADJ
admet-830	198	13	charge	charge	NOUN
admet-830	198	14	.	.	PUNCT
admet-830	199	1	as	as	SCONJ
admet-830	199	2	the	the	DET
admet-830	199	3	silica	silica	NOUN
admet-830	199	4	matrix	matrix	NOUN
admet-830	199	5	and	and	CCONJ
admet-830	199	6	fatty	fatty	NOUN
admet-830	199	7	acids	acid	NOUN
admet-830	199	8	which	which	PRON
admet-830	199	9	are	be	AUX
admet-830	199	10	liberated	liberate	VERB
admet-830	199	11	upon	upon	SCONJ
admet-830	199	12	lipase	lipase	NOUN
admet-830	199	13	-	-	PUNCT
admet-830	199	14	mediated	mediate	VERB
admet-830	199	15	digestion	digestion	NOUN
admet-830	199	16	of	of	ADP
admet-830	199	17	the	the	DET
admet-830	199	18	lipid	lipid	NOUN
admet-830	199	19	are	be	AUX
admet-830	199	20	negatively	negatively	ADV
admet-830	199	21	charged	charge	VERB
admet-830	199	22	,	,	PUNCT
admet-830	199	23	complexation	complexation	NOUN
admet-830	199	24	occurs	occur	VERB
admet-830	199	25	between	between	ADP
admet-830	199	26	the	the	DET
admet-830	199	27	ionised	ionised	ADJ
admet-830	199	28	ris	ris	NOUN
admet-830	199	29	and	and	CCONJ
admet-830	199	30	the	the	DET
admet-830	199	31	silica	silica	NOUN
admet-830	199	32	surface	surface	NOUN
admet-830	199	33	,	,	PUNCT
admet-830	199	34	interfering	interfere	VERB
admet-830	199	35	with	with	ADP
admet-830	199	36	the	the	DET
admet-830	199	37	availability	availability	NOUN
admet-830	199	38	for	for	ADP
admet-830	199	39	lipase	lipase	NOUN
admet-830	199	40	-	-	PUNCT
admet-830	199	41	lipid	lipid	NOUN
admet-830	199	42	interaction	interaction	NOUN
admet-830	199	43	,	,	PUNCT
admet-830	199	44	and	and	CCONJ
admet-830	199	45	thus	thus	ADV
admet-830	199	46	hindering	hinder	VERB
admet-830	199	47	lipid	lipid	NOUN
admet-830	199	48	digestion	digestion	NOUN
admet-830	199	49	and	and	CCONJ
admet-830	199	50	ris	ris	PROPN
admet-830	199	51	solubilisation	solubilisation	NOUN
admet-830	199	52	.	.	PUNCT
admet-830	200	1	conversely	conversely	ADV
admet-830	200	2	,	,	PUNCT
admet-830	200	3	lur	lur	PROPN
admet-830	200	4	is	be	AUX
admet-830	200	5	predominately	predominately	ADV
admet-830	200	6	unionised	unionised	ADJ
admet-830	200	7	.	.	PUNCT
admet-830	201	1	therefore	therefore	ADV
admet-830	201	2	,	,	PUNCT
admet-830	201	3	lipase	lipase	NOUN
admet-830	201	4	can	can	AUX
admet-830	201	5	readily	readily	ADV
admet-830	201	6	adsorb	adsorb	VERB
admet-830	201	7	and	and	CCONJ
admet-830	201	8	digest	digest	VERB
admet-830	201	9	the	the	DET
admet-830	201	10	lipid	lipid	NOUN
admet-830	201	11	,	,	PUNCT
admet-830	201	12	facilitating	facilitate	VERB
admet-830	201	13	the	the	DET
admet-830	201	14	production	production	NOUN
admet-830	201	15	of	of	ADP
admet-830	201	16	negatively	negatively	ADV
admet-830	201	17	charged	charge	VERB
admet-830	201	18	and	and	CCONJ
admet-830	201	19	highly	highly	ADV
admet-830	201	20	solubilising	solubilising	ADJ
admet-830	201	21	lur	lur	PROPN
admet-830	201	22	micelles	micelle	NOUN
admet-830	201	23	which	which	PRON
admet-830	201	24	can	can	AUX
admet-830	201	25	be	be	AUX
admet-830	201	26	expelled	expel	VERB
admet-830	201	27	into	into	ADP
admet-830	201	28	the	the	DET
admet-830	201	29	aqueous	aqueous	ADJ
admet-830	201	30	phase	phase	NOUN
admet-830	201	31	due	due	ADP
admet-830	201	32	to	to	ADP
admet-830	201	33	repulsion	repulsion	NOUN
admet-830	201	34	from	from	ADP
admet-830	201	35	the	the	DET
admet-830	201	36	negatively	negatively	ADV
admet-830	201	37	charged	charge	VERB
admet-830	201	38	silica	silica	NOUN
admet-830	201	39	surface	surface	NOUN
admet-830	201	40	.	.	PUNCT
admet-830	202	1	table	table	NOUN
admet-830	202	2	2	2	NUM
admet-830	202	3	.	.	X
admet-830	202	4	zeta	zeta	PROPN
admet-830	202	5	potential	potential	ADJ
admet-830	202	6	analysis	analysis	NOUN
admet-830	202	7	of	of	ADP
admet-830	202	8	the	the	DET
admet-830	202	9	various	various	ADJ
admet-830	202	10	complexes	complex	NOUN
admet-830	202	11	formed	form	VERB
admet-830	202	12	between	between	ADP
admet-830	202	13	porous	porous	ADJ
admet-830	202	14	silica	silica	NOUN
admet-830	202	15	particles	particle	NOUN
admet-830	202	16	,	,	PUNCT
admet-830	202	17	drug	drug	NOUN
admet-830	202	18	molecules	molecule	NOUN
admet-830	202	19	and	and	CCONJ
admet-830	202	20	fatty	fatty	NOUN
admet-830	202	21	acids	acid	NOUN
admet-830	202	22	(	(	PUNCT
admet-830	202	23	each	each	DET
admet-830	202	24	value	value	NOUN
admet-830	202	25	represents	represent	VERB
admet-830	202	26	the	the	DET
admet-830	202	27	mean	mean	ADJ
admet-830	202	28	±	±	NUM
admet-830	202	29	sd	sd	NOUN
admet-830	202	30	,	,	PUNCT
admet-830	202	31	n	n	NOUN
admet-830	202	32	=	=	SYM
admet-830	202	33	3	3	NUM
admet-830	202	34	)	)	PUNCT
admet-830	202	35	.	.	PUNCT
admet-830	203	1	drug	drug	NOUN
admet-830	203	2	zeta	zeta	PROPN
admet-830	203	3	potential	potential	NOUN
admet-830	203	4	(	(	PUNCT
admet-830	203	5	mv	mv	NOUN
admet-830	203	6	)	)	PUNCT
admet-830	203	7	porous	porous	ADJ
admet-830	203	8	silica	silica	NOUN
admet-830	203	9	particles	particle	NOUN
admet-830	203	10	(	(	PUNCT
admet-830	203	11	psp	psp	NOUN
admet-830	203	12	)	)	PUNCT
admet-830	203	13	psp	psp	NOUN
admet-830	203	14	:	:	PUNCT
admet-830	203	15	drug	drug	NOUN
admet-830	203	16	complex	complex	ADJ
admet-830	203	17	psp	psp	NOUN
admet-830	203	18	:	:	PUNCT
admet-830	203	19	drug	drug	NOUN
admet-830	203	20	complex	complex	NOUN
admet-830	203	21	:	:	PUNCT
admet-830	204	1	fa	fa	NOUN
admet-830	204	2	complex	complex	ADJ
admet-830	204	3	lurasidone	lurasidone	NOUN
admet-830	204	4	-20.3	-20.3	PUNCT
admet-830	204	5	±	±	NUM
admet-830	204	6	3.3	3.3	NUM
admet-830	204	7	-19.8	-19.8	SYM
admet-830	204	8	±	±	NUM
admet-830	204	9	1.6	1.6	NUM
admet-830	204	10	-22.6	-22.6	NOUN
admet-830	204	11	±	±	NUM
admet-830	204	12	4.2	4.2	NUM
admet-830	204	13	risperidone	risperidone	NOUN
admet-830	204	14	-19.1	-19.1	NOUN
admet-830	204	15	±	±	NUM
admet-830	204	16	2.7	2.7	NUM
admet-830	204	17	-12.3	-12.3	NUM
admet-830	204	18	±	±	NUM
admet-830	204	19	0.8	0.8	NUM
admet-830	204	20	-15.0	-15.0	PUNCT
admet-830	204	21	±	±	NUM
admet-830	204	22	0.3	0.3	NUM
admet-830	204	23	the	the	DET
admet-830	204	24	adsorption	adsorption	NOUN
admet-830	204	25	of	of	ADP
admet-830	204	26	positively	positively	ADV
admet-830	204	27	charged	charge	VERB
admet-830	204	28	ris	ris	NOUN
admet-830	204	29	molecules	molecule	NOUN
admet-830	204	30	on	on	ADP
admet-830	204	31	the	the	DET
admet-830	204	32	silica	silica	NOUN
admet-830	204	33	surface	surface	NOUN
admet-830	204	34	is	be	AUX
admet-830	204	35	therefore	therefore	ADV
admet-830	204	36	hypothesised	hypothesised	ADJ
admet-830	204	37	to	to	PART
admet-830	204	38	interfere	interfere	VERB
admet-830	204	39	with	with	ADP
admet-830	204	40	the	the	DET
admet-830	204	41	ability	ability	NOUN
admet-830	204	42	for	for	ADP
admet-830	204	43	lipase	lipase	NOUN
admet-830	204	44	to	to	PART
admet-830	204	45	adsorb	adsorb	VERB
admet-830	204	46	to	to	ADP
admet-830	204	47	the	the	DET
admet-830	204	48	exposed	expose	VERB
admet-830	204	49	silica	silica	NOUN
admet-830	204	50	surface	surface	NOUN
admet-830	204	51	in	in	ADP
admet-830	204	52	its	its	PRON
admet-830	204	53	active	active	ADJ
admet-830	204	54	form	form	NOUN
admet-830	204	55	,	,	PUNCT
admet-830	204	56	removing	remove	VERB
admet-830	204	57	the	the	DET
admet-830	204	58	potential	potential	NOUN
admet-830	204	59	to	to	PART
admet-830	204	60	form	form	VERB
admet-830	204	61	a	a	DET
admet-830	204	62	substrate	substrate	NOUN
admet-830	204	63	-	-	PUNCT
admet-830	204	64	enzyme	enzyme	NOUN
admet-830	204	65	complex	complex	NOUN
admet-830	204	66	that	that	PRON
admet-830	204	67	enhances	enhance	VERB
admet-830	204	68	hydrolytic	hydrolytic	ADJ
admet-830	204	69	activity	activity	NOUN
admet-830	204	70	[	[	X
admet-830	204	71	33	33	NUM
admet-830	204	72	]	]	PUNCT
admet-830	204	73	.	.	PUNCT
admet-830	205	1	the	the	DET
admet-830	205	2	digestion	digestion	NOUN
admet-830	205	3	of	of	ADP
admet-830	205	4	lipid	lipid	NOUN
admet-830	205	5	hosted	host	VERB
admet-830	205	6	within	within	ADP
admet-830	205	7	porous	porous	ADJ
admet-830	205	8	silica	silica	NOUN
admet-830	205	9	typically	typically	ADV
admet-830	205	10	leads	lead	VERB
admet-830	205	11	to	to	ADP
admet-830	205	12	the	the	DET
admet-830	205	13	rapid	rapid	ADJ
admet-830	205	14	expulsion	expulsion	NOUN
admet-830	205	15	of	of	ADP
admet-830	205	16	fatty	fatty	ADJ
admet-830	205	17	acids	acid	NOUN
admet-830	205	18	from	from	ADP
admet-830	205	19	the	the	DET
admet-830	205	20	silica	silica	NOUN
admet-830	205	21	pores	pore	NOUN
admet-830	205	22	,	,	PUNCT
admet-830	205	23	into	into	ADP
admet-830	205	24	the	the	DET
admet-830	205	25	aqueous	aqueous	ADJ
admet-830	205	26	environment	environment	NOUN
admet-830	205	27	,	,	PUNCT
admet-830	205	28	due	due	ADP
admet-830	205	29	to	to	ADP
admet-830	205	30	an	an	DET
admet-830	205	31	electrostatic	electrostatic	ADJ
admet-830	205	32	repulsion	repulsion	NOUN
admet-830	205	33	interaction	interaction	NOUN
admet-830	205	34	between	between	ADP
admet-830	205	35	the	the	DET
admet-830	205	36	negatively	negatively	ADV
admet-830	205	37	charged	charge	VERB
admet-830	205	38	silica	silica	NOUN
admet-830	205	39	surface	surface	NOUN
admet-830	205	40	and	and	CCONJ
admet-830	205	41	fatty	fatty	NOUN
admet-830	205	42	acids	acid	NOUN
admet-830	205	43	.	.	PUNCT
admet-830	206	1	this	this	DET
admet-830	206	2	process	process	NOUN
admet-830	206	3	further	far	ADV
admet-830	206	4	enhances	enhance	VERB
admet-830	206	5	lipid	lipid	ADJ
admet-830	206	6	digestion	digestion	NOUN
admet-830	206	7	within	within	ADP
admet-830	206	8	slh	slh	NOUN
admet-830	206	9	due	due	ADP
admet-830	206	10	to	to	ADP
admet-830	206	11	the	the	DET
admet-830	206	12	absence	absence	NOUN
admet-830	206	13	of	of	ADP
admet-830	206	14	surface	surface	NOUN
admet-830	206	15	active	active	ADJ
admet-830	206	16	,	,	PUNCT
admet-830	206	17	amphiphilic	amphiphilic	ADJ
admet-830	206	18	fatty	fatty	NOUN
admet-830	206	19	acids	acid	NOUN
admet-830	206	20	at	at	ADP
admet-830	206	21	the	the	DET
admet-830	206	22	lipid	lipid	NOUN
admet-830	206	23	-	-	PUNCT
admet-830	206	24	in	in	ADP
admet-830	206	25	-	-	PUNCT
admet-830	206	26	water	water	NOUN
admet-830	206	27	interface	interface	NOUN
admet-830	206	28	,	,	PUNCT
admet-830	206	29	which	which	PRON
admet-830	206	30	competitively	competitively	ADV
admet-830	206	31	inhibit	inhibit	VERB
admet-830	206	32	lipase	lipase	NOUN
admet-830	206	33	adsorption	adsorption	NOUN
admet-830	206	34	[	[	X
admet-830	206	35	27	27	NUM
admet-830	206	36	]	]	PUNCT
admet-830	206	37	.	.	PUNCT
admet-830	207	1	however	however	ADV
admet-830	207	2	,	,	PUNCT
admet-830	207	3	since	since	SCONJ
admet-830	207	4	ionised	ionised	ADJ
admet-830	207	5	ris	ris	PROPN
admet-830	207	6	can	can	AUX
admet-830	207	7	complex	complex	VERB
admet-830	207	8	with	with	ADP
admet-830	207	9	fatty	fatty	ADJ
admet-830	207	10	acids	acid	NOUN
admet-830	207	11	,	,	PUNCT
admet-830	207	12	their	their	PRON
admet-830	207	13	ability	ability	NOUN
admet-830	207	14	to	to	PART
admet-830	207	15	be	be	AUX
admet-830	207	16	expelled	expel	VERB
admet-830	207	17	into	into	ADP
admet-830	207	18	the	the	DET
admet-830	207	19	aqueous	aqueous	ADJ
admet-830	207	20	phase	phase	NOUN
admet-830	207	21	is	be	AUX
admet-830	207	22	inhibited	inhibit	VERB
admet-830	207	23	,	,	PUNCT
admet-830	207	24	and	and	CCONJ
admet-830	207	25	thus	thus	ADV
admet-830	207	26	,	,	PUNCT
admet-830	207	27	they	they	PRON
admet-830	207	28	are	be	AUX
admet-830	207	29	likely	likely	ADJ
admet-830	207	30	to	to	PART
admet-830	207	31	‘	'	PUNCT
admet-830	207	32	spoil	spoil	VERB
admet-830	207	33	’	'	PUNCT
admet-830	207	34	the	the	DET
admet-830	207	35	lipid	lipid	NOUN
admet-830	207	36	-	-	PUNCT
admet-830	207	37	in	in	ADP
admet-830	207	38	-	-	PUNCT
admet-830	207	39	water	water	NOUN
admet-830	207	40	interface	interface	NOUN
admet-830	207	41	by	by	ADP
admet-830	207	42	retarding	retard	VERB
admet-830	207	43	lipase	lipase	NOUN
admet-830	207	44	adsorption	adsorption	NOUN
admet-830	207	45	(	(	PUNCT
admet-830	207	46	figure	figure	NOUN
admet-830	207	47	8)	8)	NUM
admet-830	207	48	,	,	PUNCT
admet-830	207	49	leading	lead	VERB
admet-830	207	50	to	to	ADP
admet-830	207	51	reduced	reduce	VERB
admet-830	207	52	lipolysis	lipolysis	NOUN
admet-830	207	53	kinetics	kinetic	NOUN
admet-830	207	54	.	.	PUNCT
admet-830	208	1	dening	dene	VERB
admet-830	208	2	et	et	PROPN
admet-830	208	3	al	al	PROPN
admet-830	208	4	.	.	PROPN
admet-830	209	1	recently	recently	ADV
admet-830	209	2	characterised	characterise	VERB
admet-830	209	3	such	such	ADJ
admet-830	209	4	drug	drug	NOUN
admet-830	209	5	-	-	PUNCT
admet-830	209	6	carrier	carrier	NOUN
admet-830	209	7	and	and	CCONJ
admet-830	209	8	drug	drug	NOUN
admet-830	209	9	-	-	PUNCT
admet-830	209	10	fatty	fatty	NOUN
admet-830	209	11	acid	acid	NOUN
admet-830	209	12	interactions	interaction	NOUN
admet-830	209	13	when	when	SCONJ
admet-830	209	14	encapsulating	encapsulate	VERB
admet-830	209	15	ionisable	ionisable	ADJ
admet-830	209	16	drugs	drug	NOUN
admet-830	209	17	within	within	ADP
admet-830	209	18	solid	solid	ADJ
admet-830	209	19	-	-	PUNCT
admet-830	209	20	state	state	NOUN
admet-830	209	21	lbfs	lbfs	NOUN
admet-830	209	22	composed	compose	VERB
admet-830	209	23	of	of	ADP
admet-830	209	24	the	the	DET
admet-830	209	25	smectite	smectite	NOUN
admet-830	209	26	clay	clay	NOUN
admet-830	209	27	,	,	PUNCT
admet-830	209	28	montmorillonite	montmorillonite	ADJ
admet-830	209	29	,	,	PUNCT
admet-830	209	30	and	and	CCONJ
admet-830	209	31	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	209	32	admet	admet	PROPN
admet-830	209	33	&	&	CCONJ
admet-830	209	34	dmpk	dmpk	PROPN
admet-830	209	35	8(4	8(4	NOUN
admet-830	209	36	)	)	PUNCT
admet-830	209	37	(	(	PUNCT
admet-830	209	38	2020	2020	NUM
admet-830	209	39	)	)	PUNCT
admet-830	209	40	437	437	NUM
admet-830	209	41	-	-	SYM
admet-830	209	42	451	451	NUM
admet-830	209	43	drug	drug	NOUN
admet-830	209	44	ionisation	ionisation	NOUN
admet-830	209	45	and	and	CCONJ
admet-830	209	46	lipid	lipid	NOUN
admet-830	209	47	-	-	PUNCT
admet-830	209	48	based	base	VERB
admet-830	209	49	formulations	formulation	NOUN
admet-830	209	50	doi	doi	NOUN
admet-830	209	51	:	:	PUNCT
admet-830	209	52	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	209	53	448	448	NUM
admet-830	209	54	medium	medium	NOUN
admet-830	209	55	chain	chain	NOUN
admet-830	209	56	triglycerides	triglyceride	NOUN
admet-830	209	57	[	[	X
admet-830	209	58	34	34	NUM
admet-830	209	59	]	]	PUNCT
admet-830	209	60	.	.	PUNCT
admet-830	210	1	it	it	PRON
admet-830	210	2	was	be	AUX
admet-830	210	3	revealed	reveal	VERB
admet-830	210	4	that	that	SCONJ
admet-830	210	5	drug	drug	NOUN
admet-830	210	6	solubilisation	solubilisation	NOUN
admet-830	210	7	under	under	ADP
admet-830	210	8	simulated	simulated	ADJ
admet-830	210	9	intestinal	intestinal	ADJ
admet-830	210	10	digesting	digesting	NOUN
admet-830	210	11	conditions	condition	NOUN
admet-830	210	12	for	for	ADP
admet-830	210	13	the	the	DET
admet-830	210	14	model	model	NOUN
admet-830	210	15	weak	weak	ADJ
admet-830	210	16	base	base	NOUN
admet-830	210	17	,	,	PUNCT
admet-830	210	18	blonanserin	blonanserin	NOUN
admet-830	210	19	,	,	PUNCT
admet-830	210	20	were	be	AUX
admet-830	210	21	reduced	reduce	VERB
admet-830	210	22	3	3	NUM
admet-830	210	23	-	-	ADJ
admet-830	210	24	fold	fold	ADJ
admet-830	210	25	compared	compare	VERB
admet-830	210	26	to	to	ADP
admet-830	210	27	the	the	DET
admet-830	210	28	pure	pure	ADJ
admet-830	210	29	drug	drug	NOUN
admet-830	210	30	,	,	PUNCT
admet-830	210	31	due	due	ADP
admet-830	210	32	to	to	ADP
admet-830	210	33	the	the	DET
admet-830	210	34	electrostatic	electrostatic	ADJ
admet-830	210	35	-	-	PUNCT
admet-830	210	36	driven	drive	VERB
admet-830	210	37	interactions	interaction	NOUN
admet-830	210	38	between	between	ADP
admet-830	210	39	ionised	ionised	ADJ
admet-830	210	40	drug	drug	NOUN
admet-830	210	41	and	and	CCONJ
admet-830	210	42	montmorillonite	montmorillonite	ADJ
admet-830	210	43	and	and	CCONJ
admet-830	210	44	fatty	fatty	NOUN
admet-830	210	45	acids	acid	NOUN
admet-830	210	46	.	.	PUNCT
admet-830	211	1	inferior	inferior	ADJ
admet-830	211	2	in	in	ADP
admet-830	211	3	vitro	vitro	X
admet-830	211	4	solubilisation	solubilisation	NOUN
admet-830	211	5	performance	performance	NOUN
admet-830	211	6	correlated	correlate	VERB
admet-830	211	7	well	well	ADV
admet-830	211	8	with	with	ADP
admet-830	211	9	in	in	ADP
admet-830	211	10	vivo	vivo	ADJ
admet-830	211	11	pharmacokinetics	pharmacokinetic	NOUN
admet-830	211	12	,	,	PUNCT
admet-830	211	13	whereby	whereby	SCONJ
admet-830	211	14	blonanserin	blonanserin	NOUN
admet-830	211	15	bioavailability	bioavailability	NOUN
admet-830	211	16	was	be	AUX
admet-830	211	17	reduced	reduce	VERB
admet-830	211	18	in	in	ADP
admet-830	211	19	montmorillonite	montmorillonite	ADJ
admet-830	211	20	-	-	PUNCT
admet-830	211	21	lipid	lipid	NOUN
admet-830	211	22	hybrids	hybrid	NOUN
admet-830	211	23	,	,	PUNCT
admet-830	211	24	compared	compare	VERB
admet-830	211	25	to	to	ADP
admet-830	211	26	the	the	DET
admet-830	211	27	pure	pure	ADJ
admet-830	211	28	drug	drug	NOUN
admet-830	211	29	[	[	X
admet-830	211	30	35	35	NUM
admet-830	211	31	]	]	PUNCT
admet-830	211	32	.	.	PUNCT
admet-830	212	1	thus	thus	ADV
admet-830	212	2	,	,	PUNCT
admet-830	212	3	based	base	VERB
admet-830	212	4	on	on	ADP
admet-830	212	5	these	these	DET
admet-830	212	6	findings	finding	NOUN
admet-830	212	7	,	,	PUNCT
admet-830	212	8	it	it	PRON
admet-830	212	9	may	may	AUX
admet-830	212	10	be	be	AUX
admet-830	212	11	expected	expect	VERB
admet-830	212	12	that	that	SCONJ
admet-830	212	13	oral	oral	ADJ
admet-830	212	14	ris	ris	PROPN
admet-830	212	15	bioavailability	bioavailability	NOUN
admet-830	212	16	will	will	AUX
admet-830	212	17	also	also	ADV
admet-830	212	18	be	be	AUX
admet-830	212	19	reduced	reduce	VERB
admet-830	212	20	in	in	ADP
admet-830	212	21	vivo	vivo	NOUN
admet-830	212	22	,	,	PUNCT
admet-830	212	23	when	when	SCONJ
admet-830	212	24	formulated	formulate	VERB
admet-830	212	25	with	with	ADP
admet-830	212	26	slh	slh	PROPN
admet-830	212	27	.	.	PUNCT
admet-830	213	1	however	however	ADV
admet-830	213	2	,	,	PUNCT
admet-830	213	3	a	a	DET
admet-830	213	4	greater	great	ADJ
admet-830	213	5	dynamic	dynamic	ADJ
admet-830	213	6	flow	flow	NOUN
admet-830	213	7	is	be	AUX
admet-830	213	8	observed	observe	VERB
admet-830	213	9	in	in	ADP
admet-830	213	10	vivo	vivo	NOUN
admet-830	213	11	,	,	PUNCT
admet-830	213	12	and	and	CCONJ
admet-830	213	13	transcellular	transcellular	NOUN
admet-830	213	14	transport	transport	NOUN
admet-830	213	15	may	may	AUX
admet-830	213	16	be	be	AUX
admet-830	213	17	facilitated	facilitate	VERB
admet-830	213	18	by	by	ADP
admet-830	213	19	uptake	uptake	NOUN
admet-830	213	20	of	of	ADP
admet-830	213	21	the	the	DET
admet-830	213	22	ris	ris	PROPN
admet-830	213	23	-	-	PUNCT
admet-830	213	24	silica	silica	NOUN
admet-830	213	25	complex	complex	NOUN
admet-830	213	26	by	by	ADP
admet-830	213	27	intestinal	intestinal	ADJ
admet-830	213	28	cells	cell	NOUN
admet-830	213	29	;	;	PUNCT
admet-830	213	30	therefore	therefore	ADV
admet-830	213	31	,	,	PUNCT
admet-830	213	32	further	further	ADJ
admet-830	213	33	analysis	analysis	NOUN
admet-830	213	34	in	in	ADP
admet-830	213	35	animal	animal	NOUN
admet-830	213	36	models	model	NOUN
admet-830	213	37	is	be	AUX
admet-830	213	38	necessary	necessary	ADJ
admet-830	213	39	to	to	PART
admet-830	213	40	determine	determine	VERB
admet-830	213	41	whether	whether	SCONJ
admet-830	213	42	performance	performance	NOUN
admet-830	213	43	in	in	ADP
admet-830	213	44	vivo	vivo	NOUN
admet-830	213	45	will	will	AUX
admet-830	213	46	correlate	correlate	VERB
admet-830	213	47	with	with	ADP
admet-830	213	48	in	in	ADP
admet-830	213	49	vitro	vitro	X
admet-830	213	50	results	result	NOUN
admet-830	213	51	for	for	ADP
admet-830	213	52	ris	ris	PROPN
admet-830	213	53	-	-	NOUN
admet-830	213	54	slh	slh	NOUN
admet-830	213	55	.	.	PUNCT
admet-830	214	1	the	the	DET
admet-830	214	2	importance	importance	NOUN
admet-830	214	3	of	of	ADP
admet-830	214	4	physicochemical	physicochemical	ADJ
admet-830	214	5	properties	property	NOUN
admet-830	214	6	in	in	ADP
admet-830	214	7	formulation	formulation	NOUN
admet-830	214	8	design	design	NOUN
admet-830	214	9	a	a	DET
admet-830	214	10	summary	summary	NOUN
admet-830	214	11	of	of	ADP
admet-830	214	12	the	the	DET
admet-830	214	13	impact	impact	NOUN
admet-830	214	14	of	of	ADP
admet-830	214	15	lbf	lbf	PROPN
admet-830	214	16	type	type	NOUN
admet-830	214	17	on	on	ADP
admet-830	214	18	ris	ris	PROPN
admet-830	214	19	and	and	CCONJ
admet-830	214	20	lur	lur	PROPN
admet-830	214	21	in	in	ADP
admet-830	214	22	vitro	vitro	X
admet-830	214	23	dissolution	dissolution	NOUN
admet-830	214	24	and	and	CCONJ
admet-830	214	25	solubilisation	solubilisation	NOUN
admet-830	214	26	,	,	PUNCT
admet-830	214	27	relative	relative	ADJ
admet-830	214	28	to	to	ADP
admet-830	214	29	pure	pure	ADJ
admet-830	214	30	drug	drug	NOUN
admet-830	214	31	,	,	PUNCT
admet-830	214	32	is	be	AUX
admet-830	214	33	shown	show	VERB
admet-830	214	34	in	in	ADP
admet-830	214	35	figure	figure	NOUN
admet-830	214	36	9	9	NUM
admet-830	214	37	.	.	PUNCT
admet-830	215	1	a	a	DET
admet-830	215	2	constant	constant	ADJ
admet-830	215	3	reduction	reduction	NOUN
admet-830	215	4	in	in	ADP
admet-830	215	5	ris	ris	PROPN
admet-830	215	6	performance	performance	NOUN
admet-830	215	7	is	be	AUX
admet-830	215	8	observed	observe	VERB
admet-830	215	9	when	when	SCONJ
admet-830	215	10	ris	ris	PROPN
admet-830	215	11	was	be	AUX
admet-830	215	12	formulated	formulate	VERB
admet-830	215	13	as	as	ADP
admet-830	215	14	a	a	DET
admet-830	215	15	lbf	lbf	NOUN
admet-830	215	16	,	,	PUNCT
admet-830	215	17	especially	especially	ADV
admet-830	215	18	when	when	SCONJ
admet-830	215	19	fabricated	fabricate	VERB
admet-830	215	20	as	as	ADP
admet-830	215	21	slh	slh	PROPN
admet-830	215	22	.	.	PUNCT
admet-830	216	1	as	as	SCONJ
admet-830	216	2	described	describe	VERB
admet-830	216	3	previously	previously	ADV
admet-830	216	4	,	,	PUNCT
admet-830	216	5	this	this	PRON
admet-830	216	6	is	be	AUX
admet-830	216	7	a	a	DET
admet-830	216	8	result	result	NOUN
admet-830	216	9	from	from	ADP
admet-830	216	10	interactions	interaction	NOUN
admet-830	216	11	between	between	ADP
admet-830	216	12	ionised	ionised	ADJ
admet-830	216	13	ris	ris	PROPN
admet-830	216	14	and	and	CCONJ
admet-830	216	15	negatively	negatively	ADV
admet-830	216	16	charged	charge	VERB
admet-830	216	17	silica	silica	NOUN
admet-830	216	18	,	,	PUNCT
admet-830	216	19	thus	thus	ADV
admet-830	216	20	hindering	hinder	VERB
admet-830	216	21	drug	drug	NOUN
admet-830	216	22	release	release	NOUN
admet-830	216	23	.	.	PUNCT
admet-830	217	1	in	in	ADP
admet-830	217	2	contrast	contrast	NOUN
admet-830	217	3	,	,	PUNCT
admet-830	217	4	such	such	ADJ
admet-830	217	5	strong	strong	ADJ
admet-830	217	6	interactions	interaction	NOUN
admet-830	217	7	were	be	AUX
admet-830	217	8	not	not	PART
admet-830	217	9	present	present	ADJ
admet-830	217	10	for	for	ADP
admet-830	217	11	lur	lur	PROPN
admet-830	217	12	due	due	ADP
admet-830	217	13	to	to	ADP
admet-830	217	14	existing	exist	VERB
admet-830	217	15	predominately	predominately	ADV
admet-830	217	16	in	in	ADP
admet-830	217	17	an	an	DET
admet-830	217	18	unionised	unionised	ADJ
admet-830	217	19	form	form	NOUN
admet-830	217	20	.	.	PUNCT
admet-830	218	1	figure	figure	NOUN
admet-830	218	2	9	9	NUM
admet-830	218	3	.	.	PUNCT
admet-830	218	4	formulation	formulation	NOUN
admet-830	218	5	performance	performance	NOUN
admet-830	218	6	for	for	ADP
admet-830	218	7	ris	ris	PROPN
admet-830	218	8	and	and	CCONJ
admet-830	218	9	lur	lur	PROPN
admet-830	218	10	,	,	PUNCT
admet-830	218	11	emulsions	emulsion	NOUN
admet-830	218	12	and	and	CCONJ
admet-830	218	13	slh	slh	PROPN
admet-830	218	14	,	,	PUNCT
admet-830	218	15	relative	relative	ADJ
admet-830	218	16	to	to	ADP
admet-830	218	17	pure	pure	ADJ
admet-830	218	18	drug	drug	NOUN
admet-830	218	19	,	,	PUNCT
admet-830	218	20	during	during	ADP
admet-830	218	21	(	(	PUNCT
admet-830	218	22	a	a	X
admet-830	218	23	)	)	PUNCT
admet-830	218	24	in	in	ADP
admet-830	218	25	vitro	vitro	X
admet-830	218	26	dissolution	dissolution	NOUN
admet-830	218	27	and	and	CCONJ
admet-830	218	28	(	(	PUNCT
admet-830	218	29	b	b	NOUN
admet-830	218	30	)	)	PUNCT
admet-830	218	31	in	in	ADP
admet-830	218	32	vitro	vitro	X
admet-830	218	33	solubilisation	solubilisation	NOUN
admet-830	218	34	under	under	ADP
admet-830	218	35	digestion	digestion	NOUN
admet-830	218	36	conditions	condition	NOUN
admet-830	218	37	.	.	PUNCT
admet-830	219	1	the	the	DET
admet-830	219	2	conflicting	conflict	VERB
admet-830	219	3	performance	performance	NOUN
admet-830	219	4	observed	observe	VERB
admet-830	219	5	for	for	ADP
admet-830	219	6	ris	ris	PROPN
admet-830	219	7	and	and	CCONJ
admet-830	219	8	lur	lur	PROPN
admet-830	219	9	when	when	SCONJ
admet-830	219	10	formulated	formulate	VERB
admet-830	219	11	as	as	ADP
admet-830	219	12	a	a	DET
admet-830	219	13	lbf	lbf	PROPN
admet-830	219	14	demonstrates	demonstrate	VERB
admet-830	219	15	the	the	DET
admet-830	219	16	importance	importance	NOUN
admet-830	219	17	of	of	ADP
admet-830	219	18	drug	drug	NOUN
admet-830	219	19	pka	pka	NOUN
admet-830	219	20	and	and	CCONJ
admet-830	219	21	ionisation	ionisation	NOUN
admet-830	219	22	when	when	SCONJ
admet-830	219	23	developing	develop	VERB
admet-830	219	24	a	a	DET
admet-830	219	25	novel	novel	ADJ
admet-830	219	26	delivery	delivery	NOUN
admet-830	219	27	system	system	NOUN
admet-830	219	28	.	.	PUNCT
admet-830	220	1	a	a	DET
admet-830	220	2	blanket	blanket	NOUN
admet-830	220	3	statement	statement	NOUN
admet-830	220	4	has	have	AUX
admet-830	220	5	been	be	AUX
admet-830	220	6	used	use	VERB
admet-830	220	7	in	in	ADP
admet-830	220	8	literature	literature	NOUN
admet-830	220	9	surrounding	surround	VERB
admet-830	220	10	the	the	DET
admet-830	220	11	application	application	NOUN
admet-830	220	12	of	of	ADP
admet-830	220	13	lbfs	lbfs	NOUN
admet-830	220	14	to	to	PART
admet-830	220	15	overcome	overcome	VERB
admet-830	220	16	poor	poor	ADJ
admet-830	220	17	water	water	NOUN
admet-830	220	18	-	-	PUNCT
admet-830	220	19	solubility	solubility	NOUN
admet-830	220	20	and	and	CCONJ
admet-830	220	21	improve	improve	VERB
admet-830	220	22	dissolution	dissolution	ADJ
admet-830	220	23	kinetics	kinetic	NOUN
admet-830	221	1	[	[	X
admet-830	221	2	4	4	NUM
admet-830	221	3	,	,	PUNCT
admet-830	221	4	36	36	NUM
admet-830	221	5	,	,	PUNCT
admet-830	221	6	37	37	NUM
admet-830	221	7	]	]	PUNCT
admet-830	221	8	,	,	PUNCT
admet-830	221	9	however	however	ADV
admet-830	221	10	the	the	DET
admet-830	221	11	performance	performance	NOUN
admet-830	221	12	of	of	ADP
admet-830	221	13	ris	ris	PROPN
admet-830	221	14	diverges	diverge	VERB
admet-830	221	15	from	from	ADP
admet-830	221	16	this	this	DET
admet-830	221	17	statement	statement	NOUN
admet-830	221	18	whereby	whereby	SCONJ
admet-830	221	19	a	a	DET
admet-830	221	20	lbf	lbf	PROPN
admet-830	221	21	hindered	hinder	VERB
admet-830	221	22	drug	drug	NOUN
admet-830	221	23	performance	performance	NOUN
admet-830	221	24	.	.	PUNCT
admet-830	222	1	predictive	predictive	ADJ
admet-830	222	2	criteria	criterion	NOUN
admet-830	222	3	for	for	ADP
admet-830	222	4	determining	determine	VERB
admet-830	222	5	suitable	suitable	ADJ
admet-830	222	6	formulation	formulation	NOUN
admet-830	222	7	approaches	approach	NOUN
admet-830	222	8	for	for	ADP
admet-830	222	9	poorly	poorly	ADV
admet-830	222	10	water	water	NOUN
admet-830	222	11	-	-	PUNCT
admet-830	222	12	soluble	soluble	ADJ
admet-830	222	13	compounds	compound	NOUN
admet-830	222	14	from	from	ADP
admet-830	222	15	current	current	ADJ
admet-830	222	16	knoweldge	knoweldge	NOUN
admet-830	222	17	is	be	AUX
admet-830	222	18	scarce	scarce	ADJ
admet-830	222	19	,	,	PUNCT
admet-830	222	20	yet	yet	CCONJ
admet-830	222	21	the	the	DET
admet-830	222	22	present	present	ADJ
admet-830	222	23	study	study	NOUN
admet-830	222	24	reveals	reveal	VERB
admet-830	222	25	the	the	DET
admet-830	222	26	need	need	NOUN
admet-830	222	27	for	for	ADP
admet-830	222	28	a	a	DET
admet-830	222	29	greater	great	ADJ
admet-830	222	30	understanding	understanding	NOUN
admet-830	222	31	of	of	ADP
admet-830	222	32	physicochemical	physicochemical	ADJ
admet-830	222	33	parameters	parameter	NOUN
admet-830	222	34	,	,	PUNCT
admet-830	222	35	such	such	ADJ
admet-830	222	36	as	as	ADP
admet-830	222	37	pka	pka	PROPN
admet-830	222	38	,	,	PUNCT
admet-830	222	39	in	in	ADP
admet-830	222	40	relation	relation	NOUN
admet-830	222	41	in	in	ADP
admet-830	222	42	performance	performance	NOUN
admet-830	222	43	when	when	SCONJ
admet-830	222	44	developing	develop	VERB
admet-830	222	45	novel	novel	ADJ
admet-830	222	46	drug	drug	NOUN
admet-830	222	47	delivery	delivery	NOUN
admet-830	222	48	systems	system	NOUN
admet-830	222	49	.	.	PUNCT
admet-830	223	1	conclusions	conclusion	NOUN
admet-830	223	2	the	the	DET
admet-830	223	3	poorly	poorly	ADV
admet-830	223	4	water	water	NOUN
admet-830	223	5	-	-	PUNCT
admet-830	223	6	soluble	soluble	ADJ
admet-830	223	7	antipsychotic	antipsychotic	ADJ
admet-830	223	8	drugs	drug	NOUN
admet-830	223	9	,	,	PUNCT
admet-830	223	10	ris	ris	PROPN
admet-830	223	11	and	and	CCONJ
admet-830	223	12	lur	lur	PROPN
admet-830	223	13	,	,	PUNCT
admet-830	223	14	have	have	AUX
admet-830	223	15	been	be	AUX
admet-830	223	16	successfully	successfully	ADV
admet-830	223	17	formulated	formulate	VERB
admet-830	223	18	and	and	CCONJ
admet-830	223	19	physicochemically	physicochemically	ADV
admet-830	223	20	characterised	characterise	VERB
admet-830	223	21	as	as	ADP
admet-830	223	22	lipid	lipid	ADJ
admet-830	223	23	emulsions	emulsion	NOUN
admet-830	223	24	and	and	CCONJ
admet-830	223	25	slh	slh	ADJ
admet-830	223	26	microparticles	microparticle	NOUN
admet-830	223	27	.	.	PUNCT
admet-830	224	1	the	the	DET
admet-830	224	2	lbfs	lbfs	NOUN
admet-830	224	3	significantly	significantly	ADV
admet-830	224	4	improved	improve	VERB
admet-830	224	5	the	the	DET
admet-830	224	6	performance	performance	NOUN
admet-830	224	7	of	of	ADP
admet-830	224	8	lur	lur	PROPN
admet-830	224	9	up	up	ADP
admet-830	224	10	to	to	PART
admet-830	224	11	23	23	NUM
admet-830	224	12	-	-	NOUN
admet-830	224	13	fold	fold	VERB
admet-830	224	14	during	during	ADP
admet-830	224	15	in	in	ADP
admet-830	224	16	vitro	vitro	X
admet-830	224	17	solubilisation	solubilisation	NOUN
admet-830	224	18	studies	study	NOUN
admet-830	224	19	in	in	ADP
admet-830	224	20	comparison	comparison	NOUN
admet-830	224	21	to	to	ADP
admet-830	224	22	the	the	DET
admet-830	224	23	unformulated	unformulated	ADJ
admet-830	224	24	drug	drug	NOUN
admet-830	224	25	,	,	PUNCT
admet-830	224	26	however	however	ADV
admet-830	224	27	a	a	DET
admet-830	224	28	2.2	2.2	NUM
admet-830	224	29	-	-	ADJ
admet-830	224	30	fold	fold	ADJ
admet-830	224	31	reduction	reduction	NOUN
admet-830	224	32	in	in	ADP
admet-830	224	33	solubilisation	solubilisation	NOUN
admet-830	224	34	was	be	AUX
admet-830	224	35	observed	observe	VERB
admet-830	224	36	for	for	ADP
admet-830	224	37	ris	ris	PROPN
admet-830	224	38	due	due	ADP
admet-830	224	39	to	to	ADP
admet-830	224	40	its	its	PRON
admet-830	224	41	strong	strong	ADJ
admet-830	224	42	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	224	43	admet	admet	PROPN
admet-830	224	44	&	&	CCONJ
admet-830	224	45	dmpk	dmpk	PROPN
admet-830	224	46	8(4	8(4	NOUN
admet-830	224	47	)	)	PUNCT
admet-830	224	48	(	(	PUNCT
admet-830	224	49	2020	2020	NUM
admet-830	224	50	)	)	PUNCT
admet-830	224	51	437	437	NUM
admet-830	224	52	-	-	SYM
admet-830	224	53	451	451	NUM
admet-830	224	54	drug	drug	NOUN
admet-830	224	55	ionisation	ionisation	NOUN
admet-830	224	56	and	and	CCONJ
admet-830	224	57	lipid	lipid	NOUN
admet-830	224	58	-	-	PUNCT
admet-830	224	59	based	base	VERB
admet-830	224	60	formulations	formulation	NOUN
admet-830	224	61	doi	doi	NOUN
admet-830	224	62	:	:	PUNCT
admet-830	224	63	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	224	64	449	449	NUM
admet-830	224	65	interaction	interaction	NOUN
admet-830	224	66	with	with	ADP
admet-830	224	67	silica	silica	NOUN
admet-830	224	68	,	,	PUNCT
admet-830	224	69	demonstrating	demonstrate	VERB
admet-830	224	70	that	that	SCONJ
admet-830	224	71	the	the	DET
admet-830	224	72	application	application	NOUN
admet-830	224	73	of	of	ADP
admet-830	224	74	lbfs	lbfs	NOUN
admet-830	224	75	and	and	CCONJ
admet-830	224	76	the	the	DET
admet-830	224	77	resulting	result	VERB
admet-830	224	78	performance	performance	NOUN
admet-830	224	79	may	may	AUX
admet-830	224	80	not	not	PART
admet-830	224	81	be	be	AUX
admet-830	224	82	readily	readily	ADV
admet-830	224	83	predicted	predict	VERB
admet-830	224	84	.	.	PUNCT
admet-830	225	1	the	the	DET
admet-830	225	2	results	result	NOUN
admet-830	225	3	reveal	reveal	VERB
admet-830	225	4	that	that	SCONJ
admet-830	225	5	the	the	DET
admet-830	225	6	pka	pka	PROPN
admet-830	225	7	values	value	NOUN
admet-830	225	8	of	of	ADP
admet-830	225	9	a	a	DET
admet-830	225	10	compound	compound	NOUN
admet-830	225	11	must	must	AUX
admet-830	225	12	be	be	AUX
admet-830	225	13	considered	consider	VERB
admet-830	225	14	during	during	ADP
admet-830	225	15	formulation	formulation	NOUN
admet-830	225	16	development	development	NOUN
admet-830	225	17	,	,	PUNCT
admet-830	225	18	and	and	CCONJ
admet-830	225	19	a	a	DET
admet-830	225	20	general	general	ADJ
admet-830	225	21	statement	statement	NOUN
admet-830	225	22	that	that	SCONJ
admet-830	225	23	lbfs	lbfs	NOUN
admet-830	225	24	may	may	AUX
admet-830	225	25	overcome	overcome	VERB
admet-830	225	26	the	the	DET
admet-830	225	27	challenges	challenge	NOUN
admet-830	225	28	of	of	ADP
admet-830	225	29	all	all	DET
admet-830	225	30	poorly	poorly	ADV
admet-830	225	31	water	water	NOUN
admet-830	225	32	-	-	PUNCT
admet-830	225	33	soluble	soluble	ADJ
admet-830	225	34	drugs	drug	NOUN
admet-830	225	35	is	be	AUX
admet-830	225	36	not	not	PART
admet-830	225	37	necessarily	necessarily	ADV
admet-830	225	38	correct	correct	ADJ
admet-830	225	39	.	.	PUNCT
admet-830	226	1	therefore	therefore	ADV
admet-830	226	2	,	,	PUNCT
admet-830	226	3	further	further	ADJ
admet-830	226	4	investigation	investigation	NOUN
admet-830	226	5	is	be	AUX
admet-830	226	6	required	require	VERB
admet-830	226	7	to	to	PART
admet-830	226	8	develop	develop	VERB
admet-830	226	9	predictive	predictive	ADJ
admet-830	226	10	criteria	criterion	NOUN
admet-830	226	11	to	to	PART
admet-830	226	12	evaluate	evaluate	VERB
admet-830	226	13	the	the	DET
admet-830	226	14	performance	performance	NOUN
admet-830	226	15	of	of	ADP
admet-830	226	16	lbfs	lbfs	NOUN
admet-830	226	17	for	for	ADP
admet-830	226	18	poorly	poorly	ADV
admet-830	226	19	water	water	NOUN
admet-830	226	20	-	-	PUNCT
admet-830	226	21	soluble	soluble	ADJ
admet-830	226	22	compounds	compound	NOUN
admet-830	226	23	.	.	PUNCT
admet-830	227	1	acknowledgements	acknowledgement	NOUN
admet-830	227	2	:	:	PUNCT
admet-830	227	3	the	the	DET
admet-830	227	4	australian	australian	ADJ
admet-830	227	5	government	government	NOUN
admet-830	227	6	research	research	NOUN
admet-830	227	7	training	training	NOUN
admet-830	227	8	program	program	NOUN
admet-830	227	9	is	be	AUX
admet-830	227	10	acknowledged	acknowledge	VERB
admet-830	227	11	for	for	ADP
admet-830	227	12	the	the	DET
admet-830	227	13	phd	phd	NOUN
admet-830	227	14	scholarships	scholarship	NOUN
admet-830	227	15	of	of	ADP
admet-830	227	16	tahlia	tahlia	PROPN
admet-830	227	17	r.	r.	PROPN
admet-830	227	18	meola	meola	PROPN
admet-830	227	19	and	and	CCONJ
admet-830	227	20	hayley	hayley	PROPN
admet-830	227	21	b.	b.	PROPN
admet-830	227	22	schultz	schultz	PROPN
admet-830	227	23	.	.	PUNCT
admet-830	228	1	the	the	DET
admet-830	228	2	australian	australian	ADJ
admet-830	228	3	research	research	PROPN
admet-830	228	4	council	council	PROPN
admet-830	228	5	’s	’s	PART
admet-830	228	6	centre	centre	NOUN
admet-830	228	7	of	of	ADP
admet-830	228	8	excellence	excellence	PROPN
admet-830	228	9	in	in	ADP
admet-830	228	10	convergent	convergent	NOUN
admet-830	228	11	bio	bio	PROPN
admet-830	228	12	-	-	ADJ
admet-830	228	13	nano	nano	ADJ
admet-830	228	14	science	science	NOUN
admet-830	228	15	and	and	CCONJ
admet-830	228	16	technology	technology	NOUN
admet-830	228	17	are	be	AUX
admet-830	228	18	acknowledged	acknowledge	VERB
admet-830	228	19	for	for	ADP
admet-830	228	20	research	research	NOUN
admet-830	228	21	funding	funding	NOUN
admet-830	228	22	and	and	CCONJ
admet-830	228	23	support	support	NOUN
admet-830	228	24	.	.	PUNCT
admet-830	229	1	this	this	DET
admet-830	229	2	work	work	NOUN
admet-830	229	3	was	be	AUX
admet-830	229	4	performed	perform	VERB
admet-830	229	5	(	(	PUNCT
admet-830	229	6	in	in	ADP
admet-830	229	7	part	part	NOUN
admet-830	229	8	)	)	PUNCT
admet-830	229	9	at	at	ADP
admet-830	229	10	the	the	DET
admet-830	229	11	south	south	ADJ
admet-830	229	12	australian	australian	ADJ
admet-830	229	13	node	node	NOUN
admet-830	229	14	of	of	ADP
admet-830	229	15	the	the	DET
admet-830	229	16	australian	australian	ADJ
admet-830	229	17	national	national	ADJ
admet-830	229	18	fabrication	fabrication	NOUN
admet-830	229	19	facility	facility	NOUN
admet-830	229	20	under	under	ADP
admet-830	229	21	the	the	DET
admet-830	229	22	national	national	PROPN
admet-830	229	23	collaborative	collaborative	PROPN
admet-830	229	24	research	research	NOUN
admet-830	229	25	infrastructure	infrastructure	NOUN
admet-830	229	26	strategy	strategy	NOUN
admet-830	229	27	.	.	PUNCT
admet-830	230	1	conflict	conflict	NOUN
admet-830	230	2	of	of	ADP
admet-830	230	3	interest	interest	NOUN
admet-830	230	4	:	:	PUNCT
admet-830	230	5	none	none	NOUN
admet-830	230	6	.	.	PUNCT
admet-830	231	1	references	reference	NOUN
admet-830	231	2	[	[	X
admet-830	231	3	1	1	NUM
admet-830	231	4	]	]	X
admet-830	231	5	d.o	d.o	PROPN
admet-830	231	6	.	.	PROPN
admet-830	231	7	perkins	perkins	PROPN
admet-830	231	8	.	.	PUNCT
admet-830	232	1	predictors	predictor	NOUN
admet-830	232	2	of	of	ADP
admet-830	232	3	noncompliance	noncompliance	NOUN
admet-830	232	4	in	in	ADP
admet-830	232	5	patients	patient	NOUN
admet-830	232	6	with	with	ADP
admet-830	232	7	schizophrenia	schizophrenia	NOUN
admet-830	232	8	.	.	PUNCT
admet-830	233	1	journal	journal	NOUN
admet-830	233	2	of	of	ADP
admet-830	233	3	clinical	clinical	ADJ
admet-830	233	4	psychiatry	psychiatry	NOUN
admet-830	233	5	63	63	NUM
admet-830	233	6	(	(	PUNCT
admet-830	233	7	2002	2002	NUM
admet-830	233	8	)	)	PUNCT
admet-830	233	9	1121	1121	NUM
admet-830	233	10	-	-	SYM
admet-830	233	11	1128	1128	NUM
admet-830	233	12	.	.	PUNCT
admet-830	234	1	[	[	X
admet-830	234	2	2	2	X
admet-830	234	3	]	]	PUNCT
admet-830	234	4	j.	j.	PROPN
admet-830	234	5	dunbar	dunbar	PROPN
admet-830	234	6	-	-	PUNCT
admet-830	234	7	jacob	jacob	PROPN
admet-830	234	8	,	,	PUNCT
admet-830	234	9	m.k	m.k	PROPN
admet-830	234	10	.	.	PUNCT
admet-830	234	11	mortimer	mortimer	PROPN
admet-830	234	12	-	-	PUNCT
admet-830	234	13	stephens	stephens	PROPN
admet-830	234	14	.	.	PUNCT
admet-830	235	1	treatment	treatment	NOUN
admet-830	235	2	adherence	adherence	NOUN
admet-830	235	3	in	in	ADP
admet-830	235	4	chronic	chronic	ADJ
admet-830	235	5	disease	disease	NOUN
admet-830	235	6	.	.	PUNCT
admet-830	236	1	journal	journal	NOUN
admet-830	236	2	of	of	ADP
admet-830	236	3	clinical	clinical	ADJ
admet-830	236	4	epidemiology	epidemiology	NOUN
admet-830	236	5	54	54	NUM
admet-830	236	6	(	(	PUNCT
admet-830	236	7	2001	2001	NUM
admet-830	236	8	)	)	PUNCT
admet-830	236	9	s57	s57	NOUN
admet-830	236	10	-	-	PUNCT
admet-830	236	11	s60	s60	NOUN
admet-830	236	12	.	.	PUNCT
admet-830	237	1	[	[	X
admet-830	237	2	3	3	X
admet-830	237	3	]	]	X
admet-830	237	4	t.j	t.j	PROPN
admet-830	237	5	.	.	PROPN
admet-830	237	6	dening	dening	PROPN
admet-830	237	7	,	,	PUNCT
admet-830	237	8	s.	s.	PROPN
admet-830	237	9	rao	rao	PROPN
admet-830	237	10	,	,	PUNCT
admet-830	237	11	n.	n.	PROPN
admet-830	237	12	thomas	thomas	PROPN
admet-830	237	13	,	,	PUNCT
admet-830	237	14	c.a	c.a	PROPN
admet-830	237	15	.	.	PROPN
admet-830	237	16	prestidge	prestidge	PROPN
admet-830	237	17	.	.	PUNCT
admet-830	238	1	oral	oral	ADJ
admet-830	238	2	nanomedicine	nanomedicine	ADJ
admet-830	238	3	approaches	approach	NOUN
admet-830	238	4	for	for	ADP
admet-830	238	5	the	the	DET
admet-830	238	6	treatment	treatment	NOUN
admet-830	238	7	of	of	ADP
admet-830	238	8	psychiatric	psychiatric	ADJ
admet-830	238	9	illnesses	illness	NOUN
admet-830	238	10	.	.	PUNCT
admet-830	239	1	journal	journal	PROPN
admet-830	239	2	of	of	ADP
admet-830	239	3	controlled	control	VERB
admet-830	239	4	release	release	NOUN
admet-830	239	5	223	223	NUM
admet-830	239	6	(	(	PUNCT
admet-830	239	7	2016	2016	NUM
admet-830	239	8	)	)	PUNCT
admet-830	239	9	137	137	NUM
admet-830	239	10	-	-	SYM
admet-830	239	11	156	156	NUM
admet-830	239	12	.	.	PUNCT
admet-830	240	1	[	[	X
admet-830	240	2	4	4	X
admet-830	240	3	]	]	X
admet-830	240	4	o.m	o.m	PROPN
admet-830	240	5	.	.	PUNCT
admet-830	240	6	feeney	feeney	PROPN
admet-830	240	7	,	,	PUNCT
admet-830	240	8	m.f	m.f	PROPN
admet-830	240	9	.	.	PROPN
admet-830	240	10	crum	crum	PROPN
admet-830	240	11	,	,	PUNCT
admet-830	240	12	c.l	c.l	PROPN
admet-830	240	13	.	.	PROPN
admet-830	240	14	mcevoy	mcevoy	PROPN
admet-830	240	15	,	,	PUNCT
admet-830	240	16	n.l	n.l	PROPN
admet-830	240	17	.	.	PROPN
admet-830	240	18	trevaskis	trevaskis	PROPN
admet-830	240	19	,	,	PUNCT
admet-830	240	20	h.d	h.d	PROPN
admet-830	240	21	.	.	PROPN
admet-830	240	22	williams	williams	PROPN
admet-830	240	23	,	,	PUNCT
admet-830	240	24	c.w	c.w	PROPN
admet-830	240	25	.	.	PROPN
admet-830	240	26	pouton	pouton	PROPN
admet-830	240	27	,	,	PUNCT
admet-830	240	28	w.n	w.n	PROPN
admet-830	240	29	.	.	PROPN
admet-830	240	30	charman	charman	PROPN
admet-830	240	31	,	,	PUNCT
admet-830	240	32	c.a.s	c.a.s	PROPN
admet-830	240	33	.	.	PROPN
admet-830	240	34	bergström	bergström	NOUN
admet-830	240	35	,	,	PUNCT
admet-830	241	1	c.j.h	c.j.h	ADJ
admet-830	241	2	.	.	PUNCT
admet-830	241	3	porter	porter	NOUN
admet-830	241	4	.	.	PUNCT
admet-830	242	1	50	50	NUM
admet-830	242	2	years	year	NOUN
admet-830	242	3	of	of	ADP
admet-830	242	4	oral	oral	ADJ
admet-830	242	5	lipid	lipid	NOUN
admet-830	242	6	-	-	PUNCT
admet-830	242	7	based	base	VERB
admet-830	242	8	formulations	formulation	NOUN
admet-830	242	9	:	:	PUNCT
admet-830	242	10	provenance	provenance	NOUN
admet-830	242	11	,	,	PUNCT
admet-830	242	12	progress	progress	NOUN
admet-830	242	13	and	and	CCONJ
admet-830	242	14	future	future	ADJ
admet-830	242	15	perspectives	perspective	NOUN
admet-830	242	16	.	.	PUNCT
admet-830	243	1	advanced	advanced	ADJ
admet-830	243	2	drug	drug	NOUN
admet-830	243	3	delivery	delivery	NOUN
admet-830	243	4	reviews	review	VERB
admet-830	243	5	101	101	NUM
admet-830	243	6	(	(	PUNCT
admet-830	243	7	2016	2016	NUM
admet-830	243	8	)	)	PUNCT
admet-830	243	9	167	167	NUM
admet-830	243	10	-	-	SYM
admet-830	243	11	194	194	NUM
admet-830	243	12	.	.	PUNCT
admet-830	244	1	[	[	X
admet-830	244	2	5	5	NUM
admet-830	244	3	]	]	X
admet-830	244	4	w.n	w.n	PROPN
admet-830	244	5	.	.	PROPN
admet-830	244	6	charman	charman	PROPN
admet-830	244	7	,	,	PUNCT
admet-830	244	8	c.j.h	c.j.h	ADJ
admet-830	244	9	.	.	PUNCT
admet-830	244	10	porter	porter	PROPN
admet-830	244	11	,	,	PUNCT
admet-830	244	12	s.	s.	PROPN
admet-830	244	13	mithani	mithani	PROPN
admet-830	244	14	,	,	PUNCT
admet-830	244	15	j.b	j.b	PROPN
admet-830	244	16	.	.	PROPN
admet-830	244	17	dressman	dressman	PROPN
admet-830	244	18	.	.	PUNCT
admet-830	245	1	physicochemical	physicochemical	ADJ
admet-830	245	2	and	and	CCONJ
admet-830	245	3	physiological	physiological	ADJ
admet-830	245	4	mechanisms	mechanism	NOUN
admet-830	245	5	for	for	ADP
admet-830	245	6	the	the	DET
admet-830	245	7	effects	effect	NOUN
admet-830	245	8	of	of	ADP
admet-830	245	9	food	food	NOUN
admet-830	245	10	on	on	ADP
admet-830	245	11	drug	drug	NOUN
admet-830	245	12	absorption	absorption	NOUN
admet-830	245	13	:	:	PUNCT
admet-830	245	14	the	the	DET
admet-830	245	15	role	role	NOUN
admet-830	245	16	of	of	ADP
admet-830	245	17	lipids	lipid	NOUN
admet-830	245	18	and	and	CCONJ
admet-830	245	19	ph	ph	ADJ
admet-830	245	20	.	.	PROPN
admet-830	245	21	journal	journal	PROPN
admet-830	245	22	of	of	ADP
admet-830	245	23	pharmaceutical	pharmaceutical	PROPN
admet-830	245	24	sciences	science	NOUN
admet-830	245	25	86	86	NUM
admet-830	245	26	(	(	PUNCT
admet-830	245	27	1997	1997	NUM
admet-830	245	28	)	)	PUNCT
admet-830	245	29	269	269	NUM
admet-830	245	30	-	-	SYM
admet-830	245	31	282	282	NUM
admet-830	245	32	.	.	PUNCT
admet-830	246	1	[	[	X
admet-830	246	2	6	6	NUM
admet-830	246	3	]	]	PUNCT
admet-830	246	4	v.	v.	CCONJ
admet-830	246	5	jannin	jannin	PROPN
admet-830	246	6	,	,	PUNCT
admet-830	246	7	j.	j.	PROPN
admet-830	246	8	musakhanian	musakhanian	PROPN
admet-830	246	9	,	,	PUNCT
admet-830	246	10	d.	d.	PROPN
admet-830	246	11	marchaud	marchaud	PROPN
admet-830	246	12	.	.	PUNCT
admet-830	247	1	approaches	approach	NOUN
admet-830	247	2	for	for	ADP
admet-830	247	3	the	the	DET
admet-830	247	4	development	development	NOUN
admet-830	247	5	of	of	ADP
admet-830	247	6	solid	solid	ADJ
admet-830	247	7	and	and	CCONJ
admet-830	247	8	semi	semi	ADJ
admet-830	247	9	-	-	ADJ
admet-830	247	10	solid	solid	ADJ
admet-830	247	11	lipid	lipid	NOUN
admet-830	247	12	-	-	PUNCT
admet-830	247	13	based	base	VERB
admet-830	247	14	formulations	formulation	NOUN
admet-830	247	15	.	.	PUNCT
admet-830	248	1	advanced	advanced	ADJ
admet-830	248	2	drug	drug	NOUN
admet-830	248	3	delivery	delivery	NOUN
admet-830	248	4	reviews	review	NOUN
admet-830	248	5	60	60	NUM
admet-830	248	6	(	(	PUNCT
admet-830	248	7	2008	2008	NUM
admet-830	248	8	)	)	PUNCT
admet-830	248	9	734	734	NUM
admet-830	248	10	-	-	SYM
admet-830	248	11	746	746	NUM
admet-830	248	12	.	.	PUNCT
admet-830	249	1	[	[	X
admet-830	249	2	7	7	X
admet-830	249	3	]	]	X
admet-830	249	4	c.j.h	c.j.h	ADJ
admet-830	249	5	.	.	PUNCT
admet-830	249	6	porter	porter	PROPN
admet-830	249	7	,	,	PUNCT
admet-830	249	8	c.w	c.w	PROPN
admet-830	249	9	.	.	PROPN
admet-830	249	10	pouton	pouton	PROPN
admet-830	249	11	,	,	PUNCT
admet-830	249	12	j.f	j.f	PROPN
admet-830	249	13	.	.	PROPN
admet-830	249	14	cuine	cuine	PROPN
admet-830	249	15	,	,	PUNCT
admet-830	249	16	w.n	w.n	PROPN
admet-830	249	17	.	.	PROPN
admet-830	249	18	charman	charman	PROPN
admet-830	249	19	.	.	PUNCT
admet-830	250	1	enhancing	enhance	VERB
admet-830	250	2	intestinal	intestinal	ADJ
admet-830	250	3	drug	drug	NOUN
admet-830	250	4	solubilisation	solubilisation	NOUN
admet-830	250	5	using	use	VERB
admet-830	250	6	lipid	lipid	NOUN
admet-830	250	7	-	-	PUNCT
admet-830	250	8	based	base	VERB
admet-830	250	9	delivery	delivery	NOUN
admet-830	250	10	systems	system	NOUN
admet-830	250	11	.	.	PUNCT
admet-830	251	1	advanced	advanced	ADJ
admet-830	251	2	drug	drug	NOUN
admet-830	251	3	delivery	delivery	NOUN
admet-830	251	4	reviews	review	NOUN
admet-830	251	5	60	60	NUM
admet-830	251	6	(	(	PUNCT
admet-830	251	7	2008	2008	NUM
admet-830	251	8	)	)	PUNCT
admet-830	251	9	673	673	NUM
admet-830	251	10	-	-	SYM
admet-830	251	11	691	691	NUM
admet-830	251	12	.	.	PUNCT
admet-830	252	1	[	[	X
admet-830	252	2	8	8	NUM
admet-830	252	3	]	]	X
admet-830	252	4	c.j.h	c.j.h	ADJ
admet-830	252	5	.	.	PUNCT
admet-830	252	6	porter	porter	PROPN
admet-830	252	7	,	,	PUNCT
admet-830	252	8	n.l	n.l	PROPN
admet-830	252	9	.	.	PROPN
admet-830	252	10	trevaskis	trevaskis	PROPN
admet-830	252	11	,	,	PUNCT
admet-830	252	12	w.n	w.n	PROPN
admet-830	252	13	.	.	PROPN
admet-830	252	14	charman	charman	PROPN
admet-830	252	15	.	.	PUNCT
admet-830	253	1	lipids	lipid	NOUN
admet-830	253	2	and	and	CCONJ
admet-830	253	3	lipid	lipid	NOUN
admet-830	253	4	-	-	PUNCT
admet-830	253	5	based	base	VERB
admet-830	253	6	formulations	formulation	NOUN
admet-830	253	7	:	:	PUNCT
admet-830	253	8	optimizing	optimize	VERB
admet-830	253	9	the	the	DET
admet-830	253	10	oral	oral	ADJ
admet-830	253	11	delivery	delivery	NOUN
admet-830	253	12	of	of	ADP
admet-830	253	13	lipophilic	lipophilic	ADJ
admet-830	253	14	drugs	drug	NOUN
admet-830	253	15	.	.	PUNCT
admet-830	254	1	nature	nature	NOUN
admet-830	254	2	reviews	review	VERB
admet-830	254	3	drug	drug	NOUN
admet-830	254	4	discovery	discovery	NOUN
admet-830	254	5	6	6	NUM
admet-830	254	6	(	(	PUNCT
admet-830	254	7	2007	2007	NUM
admet-830	254	8	)	)	PUNCT
admet-830	254	9	231	231	NUM
admet-830	254	10	-	-	SYM
admet-830	254	11	248	248	NUM
admet-830	254	12	.	.	PUNCT
admet-830	255	1	[	[	X
admet-830	255	2	9	9	NUM
admet-830	255	3	]	]	X
admet-830	255	4	j.f	j.f	PROPN
admet-830	255	5	.	.	PROPN
admet-830	255	6	cuiné	cuiné	PROPN
admet-830	255	7	,	,	PUNCT
admet-830	255	8	c.l	c.l	PROPN
admet-830	255	9	.	.	PROPN
admet-830	255	10	mcevoy	mcevoy	PROPN
admet-830	255	11	,	,	PUNCT
admet-830	255	12	w.n	w.n	PROPN
admet-830	255	13	.	.	PROPN
admet-830	255	14	charman	charman	PROPN
admet-830	255	15	,	,	PUNCT
admet-830	255	16	c.w	c.w	PROPN
admet-830	255	17	.	.	PROPN
admet-830	255	18	pouton	pouton	PROPN
admet-830	255	19	,	,	PUNCT
admet-830	255	20	g.a	g.a	PROPN
admet-830	255	21	.	.	PROPN
admet-830	255	22	edwards	edwards	PROPN
admet-830	255	23	,	,	PUNCT
admet-830	255	24	h.	h.	PROPN
admet-830	255	25	benameur	benameur	PROPN
admet-830	255	26	,	,	PUNCT
admet-830	255	27	c.j.h	c.j.h	ADJ
admet-830	255	28	.	.	PUNCT
admet-830	255	29	porter	porter	NOUN
admet-830	255	30	.	.	PUNCT
admet-830	256	1	evaluation	evaluation	NOUN
admet-830	256	2	of	of	ADP
admet-830	256	3	the	the	DET
admet-830	256	4	impact	impact	NOUN
admet-830	256	5	of	of	ADP
admet-830	256	6	surfactant	surfactant	ADJ
admet-830	256	7	digestion	digestion	NOUN
admet-830	256	8	on	on	ADP
admet-830	256	9	the	the	DET
admet-830	256	10	bioavailability	bioavailability	NOUN
admet-830	256	11	of	of	ADP
admet-830	256	12	danazol	danazol	ADJ
admet-830	256	13	after	after	ADP
admet-830	256	14	oral	oral	ADJ
admet-830	256	15	administration	administration	NOUN
admet-830	256	16	of	of	ADP
admet-830	256	17	lipidic	lipidic	ADJ
admet-830	256	18	self	self	NOUN
admet-830	256	19	-	-	PUNCT
admet-830	256	20	emulsifying	emulsify	VERB
admet-830	256	21	formulations	formulation	NOUN
admet-830	256	22	to	to	ADP
admet-830	256	23	dogs	dog	NOUN
admet-830	256	24	.	.	PUNCT
admet-830	257	1	journal	journal	NOUN
admet-830	257	2	of	of	ADP
admet-830	257	3	pharmaceutical	pharmaceutical	PROPN
admet-830	257	4	sciences	science	NOUN
admet-830	257	5	97	97	NUM
admet-830	257	6	(	(	PUNCT
admet-830	257	7	2008	2008	NUM
admet-830	257	8	)	)	PUNCT
admet-830	257	9	995	995	NUM
admet-830	257	10	-	-	SYM
admet-830	257	11	1012	1012	NUM
admet-830	257	12	.	.	PUNCT
admet-830	258	1	[	[	X
admet-830	258	2	10	10	NUM
admet-830	258	3	]	]	X
admet-830	258	4	d.j	d.j	PROPN
admet-830	258	5	.	.	PROPN
admet-830	258	6	hauss	hauss	PROPN
admet-830	258	7	.	.	PUNCT
admet-830	259	1	oral	oral	ADJ
admet-830	259	2	lipid	lipid	NOUN
admet-830	259	3	-	-	PUNCT
admet-830	259	4	based	base	VERB
admet-830	259	5	formulations	formulation	NOUN
admet-830	259	6	.	.	PUNCT
admet-830	260	1	advanced	advanced	ADJ
admet-830	260	2	drug	drug	NOUN
admet-830	260	3	delivery	delivery	NOUN
admet-830	260	4	reviews	review	VERB
admet-830	260	5	59	59	NUM
admet-830	260	6	(	(	PUNCT
admet-830	260	7	2007	2007	NUM
admet-830	260	8	)	)	PUNCT
admet-830	260	9	667	667	NUM
admet-830	260	10	-	-	SYM
admet-830	260	11	676	676	NUM
admet-830	260	12	.	.	PUNCT
admet-830	261	1	[	[	X
admet-830	261	2	11	11	NUM
admet-830	261	3	]	]	X
admet-830	261	4	r.g	r.g	PROPN
admet-830	261	5	.	.	PROPN
admet-830	261	6	strickley	strickley	PROPN
admet-830	261	7	,	,	PUNCT
admet-830	261	8	currently	currently	ADV
admet-830	261	9	marketed	market	VERB
admet-830	261	10	oral	oral	ADJ
admet-830	261	11	lipid	lipid	NOUN
admet-830	261	12	-	-	PUNCT
admet-830	261	13	based	base	VERB
admet-830	261	14	dosage	dosage	NOUN
admet-830	261	15	forms	form	NOUN
admet-830	261	16	:	:	PUNCT
admet-830	261	17	drug	drug	NOUN
admet-830	261	18	products	product	NOUN
admet-830	261	19	and	and	CCONJ
admet-830	261	20	excipients	excipient	NOUN
admet-830	261	21	,	,	PUNCT
admet-830	261	22	in	in	ADP
admet-830	261	23	oral	oral	ADJ
admet-830	261	24	lipid	lipid	NOUN
admet-830	261	25	-	-	PUNCT
admet-830	261	26	based	base	VERB
admet-830	261	27	formulations	formulation	NOUN
admet-830	261	28	:	:	PUNCT
admet-830	261	29	enhancing	enhance	VERB
admet-830	261	30	the	the	DET
admet-830	261	31	bioavailability	bioavailability	NOUN
admet-830	261	32	of	of	ADP
admet-830	261	33	poorly	poorly	ADV
admet-830	261	34	water	water	NOUN
admet-830	261	35	-	-	PUNCT
admet-830	261	36	soluble	soluble	ADJ
admet-830	261	37	drugs	drug	NOUN
admet-830	261	38	,	,	PUNCT
admet-830	261	39	informa	informa	ADJ
admet-830	261	40	healthcare	healthcare	PROPN
admet-830	261	41	,	,	PUNCT
admet-830	261	42	new	new	PROPN
admet-830	261	43	york	york	PROPN
admet-830	261	44	,	,	PUNCT
admet-830	261	45	2007	2007	NUM
admet-830	262	1	[	[	X
admet-830	262	2	12	12	NUM
admet-830	262	3	]	]	X
admet-830	262	4	s.	s.	PROPN
admet-830	262	5	dokania	dokania	PROPN
admet-830	262	6	,	,	PUNCT
admet-830	262	7	a.k	a.k	PROPN
admet-830	262	8	.	.	PUNCT
admet-830	262	9	joshi	joshi	PROPN
admet-830	262	10	.	.	PUNCT
admet-830	263	1	self	self	NOUN
admet-830	263	2	-	-	PUNCT
admet-830	263	3	microemulsifying	microemulsifye	VERB
admet-830	263	4	drug	drug	NOUN
admet-830	263	5	delivery	delivery	NOUN
admet-830	263	6	system	system	NOUN
admet-830	263	7	(	(	PUNCT
admet-830	263	8	smedds)--challenges	smedds)--challenge	NOUN
admet-830	263	9	and	and	CCONJ
admet-830	263	10	road	road	NOUN
admet-830	263	11	ahead	ahead	ADV
admet-830	263	12	.	.	PUNCT
admet-830	264	1	drug	drug	NOUN
admet-830	264	2	delivery	delivery	NOUN
admet-830	264	3	22	22	NUM
admet-830	264	4	(	(	PUNCT
admet-830	264	5	2015	2015	NUM
admet-830	264	6	)	)	PUNCT
admet-830	264	7	675	675	NUM
admet-830	264	8	-	-	SYM
admet-830	264	9	690	690	NUM
admet-830	264	10	.	.	PUNCT
admet-830	265	1	[	[	X
admet-830	265	2	13	13	NUM
admet-830	265	3	]	]	X
admet-830	265	4	c.	c.	PROPN
admet-830	265	5	washington	washington	PROPN
admet-830	265	6	.	.	PUNCT
admet-830	266	1	stability	stability	NOUN
admet-830	266	2	of	of	ADP
admet-830	266	3	lipid	lipid	ADJ
admet-830	266	4	emulsions	emulsion	NOUN
admet-830	266	5	for	for	ADP
admet-830	266	6	drug	drug	NOUN
admet-830	266	7	delivery	delivery	NOUN
admet-830	266	8	.	.	PUNCT
admet-830	267	1	advanced	advanced	ADJ
admet-830	267	2	drug	drug	NOUN
admet-830	267	3	delivery	delivery	NOUN
admet-830	267	4	reviews	review	NOUN
admet-830	267	5	20	20	NUM
admet-830	267	6	(	(	PUNCT
admet-830	267	7	1996	1996	NUM
admet-830	267	8	)	)	PUNCT
admet-830	267	9	131	131	NUM
admet-830	267	10	-	-	SYM
admet-830	267	11	145	145	NUM
admet-830	267	12	.	.	PUNCT
admet-830	268	1	[	[	X
admet-830	268	2	14	14	NUM
admet-830	268	3	]	]	PUNCT
admet-830	268	4	a.	a.	PROPN
admet-830	268	5	tan	tan	PROPN
admet-830	268	6	,	,	PUNCT
admet-830	268	7	s.	s.	PROPN
admet-830	268	8	simovic	simovic	PROPN
admet-830	268	9	,	,	PUNCT
admet-830	268	10	a.k	a.k	PROPN
admet-830	268	11	.	.	PROPN
admet-830	268	12	davey	davey	NOUN
admet-830	268	13	,	,	PUNCT
admet-830	268	14	t.	t.	PROPN
admet-830	268	15	rades	rades	PROPN
admet-830	268	16	,	,	PUNCT
admet-830	268	17	c.a	c.a	PROPN
admet-830	268	18	.	.	PROPN
admet-830	268	19	prestidge	prestidge	PROPN
admet-830	268	20	.	.	PUNCT
admet-830	268	21	silica	silica	NOUN
admet-830	268	22	-	-	PUNCT
admet-830	268	23	lipid	lipid	NOUN
admet-830	268	24	hybrid	hybrid	NOUN
admet-830	268	25	(	(	PUNCT
admet-830	268	26	slh	slh	NOUN
admet-830	268	27	)	)	PUNCT
admet-830	268	28	microcapsules	microcapsule	NOUN
admet-830	268	29	:	:	PUNCT
admet-830	268	30	a	a	DET
admet-830	268	31	novel	novel	ADJ
admet-830	268	32	oral	oral	ADJ
admet-830	268	33	delivery	delivery	NOUN
admet-830	268	34	system	system	NOUN
admet-830	268	35	for	for	ADP
admet-830	268	36	poorly	poorly	ADV
admet-830	268	37	soluble	soluble	ADJ
admet-830	268	38	drugs	drug	NOUN
admet-830	268	39	.	.	PUNCT
admet-830	269	1	journal	journal	PROPN
admet-830	269	2	of	of	ADP
admet-830	269	3	controlled	control	VERB
admet-830	269	4	release	release	NOUN
admet-830	269	5	134	134	NUM
admet-830	269	6	(	(	PUNCT
admet-830	269	7	2009	2009	NUM
admet-830	269	8	)	)	PUNCT
admet-830	269	9	62	62	NUM
admet-830	269	10	-	-	SYM
admet-830	269	11	70	70	NUM
admet-830	269	12	.	.	PUNCT
admet-830	270	1	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	270	2	admet	admet	PROPN
admet-830	270	3	&	&	CCONJ
admet-830	270	4	dmpk	dmpk	PROPN
admet-830	270	5	8(4	8(4	NOUN
admet-830	270	6	)	)	PUNCT
admet-830	270	7	(	(	PUNCT
admet-830	270	8	2020	2020	NUM
admet-830	270	9	)	)	PUNCT
admet-830	270	10	437	437	NUM
admet-830	270	11	-	-	SYM
admet-830	270	12	451	451	NUM
admet-830	270	13	drug	drug	NOUN
admet-830	270	14	ionisation	ionisation	NOUN
admet-830	270	15	and	and	CCONJ
admet-830	270	16	lipid	lipid	NOUN
admet-830	270	17	-	-	PUNCT
admet-830	270	18	based	base	VERB
admet-830	270	19	formulations	formulation	NOUN
admet-830	270	20	doi	doi	NOUN
admet-830	270	21	:	:	PUNCT
admet-830	270	22	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	270	23	450	450	NUM
admet-830	270	24	[	[	SYM
admet-830	270	25	15	15	NUM
admet-830	270	26	]	]	X
admet-830	270	27	h.b	h.b	PROPN
admet-830	270	28	.	.	PROPN
admet-830	270	29	schultz	schultz	PROPN
admet-830	270	30	,	,	PUNCT
admet-830	270	31	n.	n.	PROPN
admet-830	270	32	thomas	thomas	PROPN
admet-830	270	33	,	,	PUNCT
admet-830	270	34	s.	s.	PROPN
admet-830	270	35	rao	rao	PROPN
admet-830	270	36	,	,	PUNCT
admet-830	270	37	c.a	c.a	PROPN
admet-830	270	38	.	.	PROPN
admet-830	270	39	prestidge	prestidge	PROPN
admet-830	270	40	.	.	PUNCT
admet-830	271	1	supersaturated	supersaturate	VERB
admet-830	271	2	silica	silica	NOUN
admet-830	271	3	-	-	PUNCT
admet-830	271	4	lipid	lipid	NOUN
admet-830	271	5	hybrids	hybrid	NOUN
admet-830	271	6	(	(	PUNCT
admet-830	271	7	super	super	ADJ
admet-830	271	8	-	-	ADJ
admet-830	271	9	slh	slh	ADJ
admet-830	271	10	):	):	PUNCT
admet-830	271	11	an	an	DET
admet-830	271	12	improved	improve	VERB
admet-830	271	13	solid	solid	ADJ
admet-830	271	14	-	-	PUNCT
admet-830	271	15	state	state	NOUN
admet-830	271	16	lipid	lipid	NOUN
admet-830	271	17	-	-	PUNCT
admet-830	271	18	based	base	VERB
admet-830	271	19	oral	oral	ADJ
admet-830	271	20	drug	drug	NOUN
admet-830	271	21	delivery	delivery	NOUN
admet-830	271	22	system	system	NOUN
admet-830	271	23	with	with	ADP
admet-830	271	24	enhanced	enhanced	ADJ
admet-830	271	25	drug	drug	NOUN
admet-830	271	26	loading	loading	NOUN
admet-830	271	27	.	.	PUNCT
admet-830	272	1	european	european	PROPN
admet-830	272	2	journal	journal	PROPN
admet-830	272	3	of	of	ADP
admet-830	272	4	pharmaceutics	pharmaceutic	NOUN
admet-830	272	5	and	and	CCONJ
admet-830	272	6	biopharmaceutics	biopharmaceutic	NOUN
admet-830	272	7	125	125	NUM
admet-830	272	8	(	(	PUNCT
admet-830	272	9	2018	2018	NUM
admet-830	272	10	)	)	PUNCT
admet-830	272	11	13	13	NUM
admet-830	272	12	-	-	SYM
admet-830	272	13	20	20	NUM
admet-830	272	14	.	.	PUNCT
admet-830	273	1	[	[	X
admet-830	273	2	16	16	NUM
admet-830	273	3	]	]	PUNCT
admet-830	273	4	a.	a.	PROPN
admet-830	273	5	tan	tan	PROPN
admet-830	273	6	,	,	PUNCT
admet-830	273	7	a.k	a.k	PROPN
admet-830	273	8	.	.	PROPN
admet-830	273	9	davey	davey	PROPN
admet-830	273	10	,	,	PUNCT
admet-830	273	11	c.a	c.a	PROPN
admet-830	273	12	.	.	PROPN
admet-830	273	13	prestidge	prestidge	PROPN
admet-830	273	14	.	.	PUNCT
admet-830	273	15	silica	silica	NOUN
admet-830	273	16	-	-	PUNCT
admet-830	273	17	lipid	lipid	NOUN
admet-830	273	18	hybrid	hybrid	NOUN
admet-830	273	19	(	(	PUNCT
admet-830	273	20	slh	slh	PROPN
admet-830	273	21	)	)	PUNCT
admet-830	273	22	versus	versus	ADP
admet-830	273	23	non	non	ADJ
admet-830	273	24	-	-	ADJ
admet-830	273	25	lipid	lipid	ADJ
admet-830	273	26	formulations	formulation	NOUN
admet-830	273	27	for	for	ADP
admet-830	273	28	optimising	optimise	VERB
admet-830	273	29	the	the	DET
admet-830	273	30	dose	dose	NOUN
admet-830	273	31	-	-	PUNCT
admet-830	273	32	dependent	dependent	ADJ
admet-830	273	33	oral	oral	ADJ
admet-830	273	34	absorption	absorption	NOUN
admet-830	273	35	of	of	ADP
admet-830	273	36	celecoxib	celecoxib	PROPN
admet-830	273	37	.	.	PUNCT
admet-830	274	1	pharmaceutical	pharmaceutical	PROPN
admet-830	274	2	research	research	NOUN
admet-830	274	3	28	28	NUM
admet-830	274	4	(	(	PUNCT
admet-830	274	5	2011	2011	NUM
admet-830	274	6	)	)	PUNCT
admet-830	274	7	2273	2273	NUM
admet-830	274	8	-	-	SYM
admet-830	274	9	2287	2287	NUM
admet-830	274	10	.	.	PUNCT
admet-830	275	1	[	[	X
admet-830	275	2	17	17	NUM
admet-830	275	3	]	]	X
admet-830	275	4	h.b	h.b	PROPN
admet-830	275	5	.	.	PROPN
admet-830	275	6	schultz	schultz	PROPN
admet-830	275	7	,	,	PUNCT
admet-830	275	8	p.	p.	PROPN
admet-830	275	9	joyce	joyce	PROPN
admet-830	275	10	,	,	PUNCT
admet-830	275	11	n.	n.	PROPN
admet-830	275	12	thomas	thomas	PROPN
admet-830	275	13	,	,	PUNCT
admet-830	275	14	c.a	c.a	PROPN
admet-830	275	15	.	.	PROPN
admet-830	275	16	prestidge	prestidge	PROPN
admet-830	275	17	.	.	PUNCT
admet-830	275	18	supersaturated	supersaturate	VERB
admet-830	275	19	-	-	PUNCT
admet-830	275	20	silica	silica	NOUN
admet-830	275	21	lipid	lipid	NOUN
admet-830	275	22	hybrids	hybrid	NOUN
admet-830	275	23	improve	improve	VERB
admet-830	275	24	in	in	ADP
admet-830	275	25	vitro	vitro	X
admet-830	275	26	solubilization	solubilization	NOUN
admet-830	275	27	of	of	ADP
admet-830	275	28	abiraterone	abiraterone	NOUN
admet-830	275	29	acetate	acetate	NOUN
admet-830	275	30	.	.	PUNCT
admet-830	276	1	pharmaceutical	pharmaceutical	PROPN
admet-830	276	2	research	research	NOUN
admet-830	276	3	37	37	NUM
admet-830	276	4	(	(	PUNCT
admet-830	276	5	2020	2020	NUM
admet-830	276	6	)	)	PUNCT
admet-830	276	7	77	77	NUM
admet-830	276	8	.	.	PUNCT
admet-830	277	1	[	[	X
admet-830	277	2	18	18	NUM
admet-830	277	3	]	]	X
admet-830	277	4	t.r	t.r	PROPN
admet-830	277	5	.	.	PROPN
admet-830	277	6	meola	meola	PROPN
admet-830	277	7	,	,	PUNCT
admet-830	277	8	h.b	h.b	PROPN
admet-830	277	9	.	.	PROPN
admet-830	277	10	schultz	schultz	PROPN
admet-830	277	11	,	,	PUNCT
admet-830	277	12	k.f	k.f	PROPN
admet-830	277	13	.	.	PROPN
admet-830	277	14	peressin	peressin	PROPN
admet-830	277	15	,	,	PUNCT
admet-830	277	16	c.a	c.a	PROPN
admet-830	277	17	.	.	PROPN
admet-830	277	18	prestidge	prestidge	PROPN
admet-830	277	19	.	.	PUNCT
admet-830	278	1	enhancing	enhance	VERB
admet-830	278	2	the	the	DET
admet-830	278	3	oral	oral	ADJ
admet-830	278	4	bioavailability	bioavailability	NOUN
admet-830	278	5	of	of	ADP
admet-830	278	6	simvastatin	simvastatin	NOUN
admet-830	278	7	with	with	ADP
admet-830	278	8	silica	silica	NOUN
admet-830	278	9	-	-	PUNCT
admet-830	278	10	lipid	lipid	NOUN
admet-830	278	11	hybrid	hybrid	ADJ
admet-830	278	12	particles	particle	NOUN
admet-830	278	13	:	:	PUNCT
admet-830	278	14	the	the	DET
admet-830	278	15	effect	effect	NOUN
admet-830	278	16	of	of	ADP
admet-830	278	17	supersaturation	supersaturation	NOUN
admet-830	278	18	and	and	CCONJ
admet-830	278	19	silica	silica	NOUN
admet-830	278	20	geometry	geometry	NOUN
admet-830	278	21	.	.	PUNCT
admet-830	279	1	european	european	PROPN
admet-830	279	2	journal	journal	PROPN
admet-830	279	3	of	of	ADP
admet-830	279	4	pharmaceutical	pharmaceutical	PROPN
admet-830	279	5	sciences	science	NOUN
admet-830	279	6	150	150	NUM
admet-830	279	7	(	(	PUNCT
admet-830	279	8	2020	2020	NUM
admet-830	279	9	)	)	PUNCT
admet-830	279	10	105357	105357	NUM
admet-830	279	11	.	.	PUNCT
admet-830	280	1	[	[	X
admet-830	280	2	19	19	NUM
admet-830	280	3	]	]	X
admet-830	280	4	p.	p.	PROPN
admet-830	280	5	joyce	joyce	PROPN
admet-830	280	6	,	,	PUNCT
admet-830	280	7	t.j	t.j	PROPN
admet-830	280	8	.	.	PROPN
admet-830	280	9	barnes	barnes	PROPN
admet-830	280	10	,	,	PUNCT
admet-830	280	11	b.j	b.j	PROPN
admet-830	280	12	.	.	PROPN
admet-830	280	13	boyd	boyd	PROPN
admet-830	280	14	,	,	PUNCT
admet-830	280	15	c.a	c.a	PROPN
admet-830	280	16	.	.	PROPN
admet-830	280	17	prestidge	prestidge	PROPN
admet-830	280	18	.	.	PUNCT
admet-830	281	1	porous	porous	ADJ
admet-830	281	2	nanostructure	nanostructure	NOUN
admet-830	281	3	controls	control	NOUN
admet-830	281	4	kinetics	kinetic	NOUN
admet-830	281	5	,	,	PUNCT
admet-830	281	6	disposition	disposition	NOUN
admet-830	281	7	and	and	CCONJ
admet-830	281	8	self	self	NOUN
admet-830	281	9	-	-	PUNCT
admet-830	281	10	assembly	assembly	NOUN
admet-830	281	11	structure	structure	NOUN
admet-830	281	12	of	of	ADP
admet-830	281	13	lipid	lipid	ADJ
admet-830	281	14	digestion	digestion	NOUN
admet-830	281	15	products	product	NOUN
admet-830	281	16	.	.	PUNCT
admet-830	282	1	rsc	rsc	PROPN
admet-830	282	2	advances	advance	VERB
admet-830	282	3	6	6	NUM
admet-830	282	4	(	(	PUNCT
admet-830	282	5	2016	2016	NUM
admet-830	282	6	)	)	PUNCT
admet-830	282	7	78385	78385	NUM
admet-830	282	8	-	-	SYM
admet-830	282	9	78395	78395	NUM
admet-830	282	10	.	.	PUNCT
admet-830	283	1	[	[	X
admet-830	283	2	20	20	NUM
admet-830	283	3	]	]	PUNCT
admet-830	283	4	s.	s.	PROPN
admet-830	283	5	shah	shah	PROPN
admet-830	283	6	,	,	PUNCT
admet-830	283	7	b.	b.	PROPN
admet-830	283	8	parmar	parmar	PROPN
admet-830	283	9	,	,	PUNCT
admet-830	283	10	m.	m.	NOUN
admet-830	283	11	soniwala	soniwala	NOUN
admet-830	283	12	,	,	PUNCT
admet-830	283	13	j.	j.	PROPN
admet-830	283	14	chavda	chavda	PROPN
admet-830	283	15	.	.	PUNCT
admet-830	284	1	design	design	NOUN
admet-830	284	2	,	,	PUNCT
admet-830	284	3	optimization	optimization	NOUN
admet-830	284	4	,	,	PUNCT
admet-830	284	5	and	and	CCONJ
admet-830	284	6	evaluation	evaluation	NOUN
admet-830	284	7	of	of	ADP
admet-830	284	8	lurasidone	lurasidone	NOUN
admet-830	284	9	hydrochloride	hydrochloride	NOUN
admet-830	284	10	nanocrystals	nanocrystal	NOUN
admet-830	284	11	.	.	PUNCT
admet-830	285	1	aaps	aap	NOUN
admet-830	285	2	pharmscitech	pharmscitech	VERB
admet-830	285	3	17	17	NUM
admet-830	285	4	(	(	PUNCT
admet-830	285	5	2016	2016	NUM
admet-830	285	6	)	)	PUNCT
admet-830	285	7	1150	1150	NUM
admet-830	285	8	-	-	SYM
admet-830	285	9	1158	1158	NUM
admet-830	285	10	.	.	PUNCT
admet-830	286	1	[	[	X
admet-830	286	2	21	21	NUM
admet-830	286	3	]	]	X
admet-830	286	4	g.	g.	PROPN
admet-830	286	5	mannens	mannens	PROPN
admet-830	286	6	,	,	PUNCT
admet-830	286	7	w.	w.	PROPN
admet-830	286	8	meuldermans	meuldermans	PROPN
admet-830	286	9	,	,	PUNCT
admet-830	286	10	e.	e.	PROPN
admet-830	286	11	snoeck	snoeck	PROPN
admet-830	286	12	,	,	PUNCT
admet-830	286	13	j.	j.	PROPN
admet-830	286	14	heykants	heykants	PROPN
admet-830	286	15	.	.	PUNCT
admet-830	287	1	plasma	plasma	NOUN
admet-830	287	2	protein	protein	NOUN
admet-830	287	3	binding	bind	VERB
admet-830	287	4	of	of	ADP
admet-830	287	5	risperidone	risperidone	NOUN
admet-830	287	6	and	and	CCONJ
admet-830	287	7	its	its	PRON
admet-830	287	8	distribution	distribution	NOUN
admet-830	287	9	in	in	ADP
admet-830	287	10	blood	blood	NOUN
admet-830	287	11	.	.	PUNCT
admet-830	288	1	psychopharmacology	psychopharmacology	NOUN
admet-830	288	2	114	114	NUM
admet-830	288	3	(	(	PUNCT
admet-830	288	4	1994	1994	NUM
admet-830	288	5	)	)	PUNCT
admet-830	288	6	566	566	NUM
admet-830	288	7	-	-	SYM
admet-830	288	8	572	572	NUM
admet-830	288	9	.	.	PUNCT
admet-830	289	1	[	[	X
admet-830	289	2	22	22	NUM
admet-830	289	3	]	]	PUNCT
admet-830	289	4	l.	l.	PROPN
admet-830	289	5	citrome	citrome	PROPN
admet-830	289	6	.	.	PUNCT
admet-830	290	1	lurasidone	lurasidone	NOUN
admet-830	290	2	for	for	ADP
admet-830	290	3	schizophrenia	schizophrenia	NOUN
admet-830	290	4	:	:	PUNCT
admet-830	290	5	a	a	DET
admet-830	290	6	review	review	NOUN
admet-830	290	7	of	of	ADP
admet-830	290	8	the	the	DET
admet-830	290	9	efficacy	efficacy	NOUN
admet-830	290	10	and	and	CCONJ
admet-830	290	11	safety	safety	NOUN
admet-830	290	12	profile	profile	NOUN
admet-830	290	13	for	for	ADP
admet-830	290	14	this	this	DET
admet-830	290	15	newly	newly	ADV
admet-830	290	16	approved	approve	VERB
admet-830	290	17	second	second	ADJ
admet-830	290	18	-	-	PUNCT
admet-830	290	19	generation	generation	NOUN
admet-830	290	20	antipsychotic	antipsychotic	ADJ
admet-830	290	21	.	.	PUNCT
admet-830	291	1	international	international	ADJ
admet-830	291	2	journal	journal	NOUN
admet-830	291	3	of	of	ADP
admet-830	291	4	clinical	clinical	ADJ
admet-830	291	5	practice	practice	NOUN
admet-830	291	6	65	65	NUM
admet-830	291	7	(	(	PUNCT
admet-830	291	8	2011	2011	NUM
admet-830	291	9	)	)	PUNCT
admet-830	291	10	189210	189210	NUM
admet-830	291	11	.	.	PUNCT
admet-830	292	1	[	[	X
admet-830	292	2	23	23	NUM
admet-830	292	3	]	]	X
admet-830	292	4	l.	l.	PROPN
admet-830	292	5	citrome	citrome	PROPN
admet-830	292	6	.	.	PUNCT
admet-830	293	1	using	use	VERB
admet-830	293	2	oral	oral	ADJ
admet-830	293	3	ziprasidone	ziprasidone	NOUN
admet-830	293	4	effectively	effectively	ADV
admet-830	293	5	:	:	PUNCT
admet-830	293	6	the	the	DET
admet-830	293	7	food	food	NOUN
admet-830	293	8	effect	effect	NOUN
admet-830	293	9	and	and	CCONJ
admet-830	293	10	dose	dose	NOUN
admet-830	293	11	-	-	PUNCT
admet-830	293	12	response	response	NOUN
admet-830	293	13	.	.	PUNCT
admet-830	294	1	adv	adv	INTJ
admet-830	294	2	ther	ther	VERB
admet-830	294	3	26	26	NUM
admet-830	294	4	(	(	PUNCT
admet-830	294	5	2009	2009	NUM
admet-830	294	6	)	)	PUNCT
admet-830	295	1	739	739	NUM
admet-830	295	2	-	-	SYM
admet-830	295	3	748	748	NUM
admet-830	295	4	.	.	PUNCT
admet-830	296	1	[	[	X
admet-830	296	2	24	24	NUM
admet-830	296	3	]	]	X
admet-830	296	4	v.	v.	PROPN
admet-830	296	5	madaan	madaan	PROPN
admet-830	296	6	,	,	PUNCT
admet-830	296	7	d.p	d.p	PROPN
admet-830	296	8	.	.	PROPN
admet-830	296	9	bestha	bestha	PROPN
admet-830	296	10	,	,	PUNCT
admet-830	296	11	v.	v.	PROPN
admet-830	296	12	kolli	kolli	PROPN
admet-830	296	13	,	,	PUNCT
admet-830	296	14	s.	s.	PROPN
admet-830	296	15	jauhari	jauhari	PROPN
admet-830	296	16	,	,	PUNCT
admet-830	296	17	r.c	r.c	PROPN
admet-830	296	18	.	.	PROPN
admet-830	296	19	burket	burket	PROPN
admet-830	296	20	.	.	PUNCT
admet-830	297	1	clinical	clinical	ADJ
admet-830	297	2	utility	utility	NOUN
admet-830	297	3	of	of	ADP
admet-830	297	4	the	the	DET
admet-830	297	5	risperidone	risperidone	NOUN
admet-830	297	6	formulations	formulation	NOUN
admet-830	297	7	in	in	ADP
admet-830	297	8	the	the	DET
admet-830	297	9	management	management	NOUN
admet-830	297	10	of	of	ADP
admet-830	297	11	schizophrenia	schizophrenia	NOUN
admet-830	297	12	.	.	PUNCT
admet-830	298	1	neuropsychiatric	neuropsychiatric	ADJ
admet-830	298	2	disease	disease	NOUN
admet-830	298	3	and	and	CCONJ
admet-830	298	4	treatment	treatment	NOUN
admet-830	298	5	7	7	NUM
admet-830	298	6	(	(	PUNCT
admet-830	298	7	2011	2011	NUM
admet-830	298	8	)	)	PUNCT
admet-830	298	9	611	611	NUM
admet-830	298	10	-	-	SYM
admet-830	298	11	620	620	NUM
admet-830	298	12	.	.	PUNCT
admet-830	299	1	[	[	X
admet-830	299	2	25	25	NUM
admet-830	299	3	]	]	X
admet-830	299	4	l.	l.	PROPN
admet-830	299	5	sek	sek	PROPN
admet-830	299	6	,	,	PUNCT
admet-830	299	7	c.j.h	c.j.h	ADJ
admet-830	299	8	.	.	PUNCT
admet-830	299	9	porter	porter	PROPN
admet-830	299	10	,	,	PUNCT
admet-830	299	11	w.n	w.n	PROPN
admet-830	299	12	.	.	PROPN
admet-830	299	13	charman	charman	PROPN
admet-830	299	14	.	.	PUNCT
admet-830	300	1	characterisation	characterisation	NOUN
admet-830	300	2	and	and	CCONJ
admet-830	300	3	quantification	quantification	NOUN
admet-830	300	4	of	of	ADP
admet-830	300	5	medium	medium	ADJ
admet-830	300	6	chain	chain	NOUN
admet-830	300	7	and	and	CCONJ
admet-830	300	8	long	long	ADJ
admet-830	300	9	chain	chain	NOUN
admet-830	300	10	triglycerides	triglyceride	NOUN
admet-830	300	11	and	and	CCONJ
admet-830	300	12	their	their	PRON
admet-830	300	13	in	in	X
admet-830	300	14	vitro	vitro	X
admet-830	300	15	digestion	digestion	NOUN
admet-830	300	16	products	product	NOUN
admet-830	300	17	,	,	PUNCT
admet-830	300	18	by	by	ADP
admet-830	300	19	hptlc	hptlc	NOUN
admet-830	300	20	coupled	couple	VERB
admet-830	300	21	with	with	ADP
admet-830	300	22	in	in	ADP
admet-830	300	23	situ	situ	ADJ
admet-830	300	24	densitometric	densitometric	ADJ
admet-830	300	25	analysis	analysis	NOUN
admet-830	300	26	.	.	PUNCT
admet-830	301	1	journal	journal	NOUN
admet-830	301	2	of	of	ADP
admet-830	301	3	pharmaceutical	pharmaceutical	NOUN
admet-830	301	4	and	and	CCONJ
admet-830	301	5	biomedical	biomedical	ADJ
admet-830	301	6	analysis	analysis	NOUN
admet-830	301	7	25	25	NUM
admet-830	301	8	(	(	PUNCT
admet-830	301	9	2001	2001	NUM
admet-830	301	10	)	)	PUNCT
admet-830	301	11	651	651	NUM
admet-830	301	12	-	-	SYM
admet-830	301	13	661	661	NUM
admet-830	301	14	.	.	PUNCT
admet-830	302	1	[	[	X
admet-830	302	2	26	26	NUM
admet-830	302	3	]	]	X
admet-830	302	4	t.s	t.s	PROPN
admet-830	302	5	.	.	PROPN
admet-830	302	6	wiedmann	wiedmann	PROPN
admet-830	302	7	,	,	PUNCT
admet-830	302	8	l.	l.	PROPN
admet-830	302	9	kamel	kamel	PROPN
admet-830	302	10	.	.	PUNCT
admet-830	302	11	examination	examination	NOUN
admet-830	302	12	of	of	ADP
admet-830	302	13	the	the	DET
admet-830	302	14	solubilization	solubilization	NOUN
admet-830	302	15	of	of	ADP
admet-830	302	16	drugs	drug	NOUN
admet-830	302	17	by	by	ADP
admet-830	302	18	bile	bile	NOUN
admet-830	302	19	salt	salt	NOUN
admet-830	302	20	micelles	micelle	NOUN
admet-830	302	21	.	.	PUNCT
admet-830	302	22	journal	journal	NOUN
admet-830	302	23	of	of	ADP
admet-830	302	24	pharmaceutical	pharmaceutical	PROPN
admet-830	302	25	sciences	science	NOUN
admet-830	302	26	91	91	NUM
admet-830	302	27	(	(	PUNCT
admet-830	302	28	2002	2002	NUM
admet-830	302	29	)	)	PUNCT
admet-830	302	30	1743	1743	NUM
admet-830	302	31	-	-	SYM
admet-830	302	32	1764	1764	NUM
admet-830	302	33	.	.	PUNCT
admet-830	303	1	[	[	X
admet-830	303	2	27	27	NUM
admet-830	303	3	]	]	X
admet-830	303	4	p.	p.	PROPN
admet-830	303	5	joyce	joyce	PROPN
admet-830	303	6	,	,	PUNCT
admet-830	303	7	h.	h.	PROPN
admet-830	303	8	gustafsson	gustafsson	PROPN
admet-830	303	9	,	,	PUNCT
admet-830	303	10	c.a	c.a	PROPN
admet-830	303	11	.	.	PROPN
admet-830	303	12	prestidge	prestidge	PROPN
admet-830	303	13	.	.	PUNCT
admet-830	304	1	engineering	engineer	VERB
admet-830	304	2	intelligent	intelligent	ADJ
admet-830	304	3	particle	particle	NOUN
admet-830	304	4	-	-	PUNCT
admet-830	304	5	lipid	lipid	NOUN
admet-830	304	6	composites	composite	NOUN
admet-830	304	7	that	that	PRON
admet-830	304	8	control	control	VERB
admet-830	304	9	lipase	lipase	NOUN
admet-830	304	10	-	-	PUNCT
admet-830	304	11	mediated	mediate	VERB
admet-830	304	12	digestion	digestion	NOUN
admet-830	304	13	.	.	PUNCT
admet-830	305	1	advances	advance	NOUN
admet-830	305	2	in	in	ADP
admet-830	305	3	colloid	colloid	NOUN
admet-830	305	4	and	and	CCONJ
admet-830	305	5	interface	interface	NOUN
admet-830	305	6	science	science	NOUN
admet-830	305	7	260	260	NUM
admet-830	305	8	(	(	PUNCT
admet-830	305	9	2018	2018	NUM
admet-830	305	10	)	)	PUNCT
admet-830	305	11	1	1	NUM
admet-830	305	12	-	-	SYM
admet-830	305	13	23	23	NUM
admet-830	305	14	.	.	PUNCT
admet-830	306	1	[	[	X
admet-830	306	2	28	28	NUM
admet-830	306	3	]	]	X
admet-830	306	4	n.	n.	PROPN
admet-830	306	5	thomas	thomas	PROPN
admet-830	306	6	,	,	PUNCT
admet-830	306	7	t.	t.	PROPN
admet-830	306	8	rades	rades	PROPN
admet-830	306	9	,	,	PUNCT
admet-830	306	10	a.	a.	NOUN
admet-830	306	11	müllertz	müllertz	NOUN
admet-830	306	12	.	.	PUNCT
admet-830	307	1	recent	recent	ADJ
admet-830	307	2	developments	development	NOUN
admet-830	307	3	in	in	ADP
admet-830	307	4	oral	oral	ADJ
admet-830	307	5	lipid	lipid	NOUN
admet-830	307	6	-	-	PUNCT
admet-830	307	7	based	base	VERB
admet-830	307	8	drug	drug	NOUN
admet-830	307	9	delivery	delivery	NOUN
admet-830	307	10	.	.	PUNCT
admet-830	308	1	journal	journal	NOUN
admet-830	308	2	of	of	ADP
admet-830	308	3	drug	drug	NOUN
admet-830	308	4	delivery	delivery	NOUN
admet-830	308	5	science	science	NOUN
admet-830	308	6	and	and	CCONJ
admet-830	308	7	technology	technology	NOUN
admet-830	308	8	23	23	NUM
admet-830	308	9	(	(	PUNCT
admet-830	308	10	2013	2013	NUM
admet-830	308	11	)	)	PUNCT
admet-830	308	12	375	375	NUM
admet-830	308	13	-	-	SYM
admet-830	308	14	382	382	NUM
admet-830	308	15	.	.	PUNCT
admet-830	309	1	[	[	X
admet-830	309	2	29	29	NUM
admet-830	309	3	]	]	PUNCT
admet-830	309	4	s.	s.	PROPN
admet-830	309	5	chakraborty	chakraborty	PROPN
admet-830	309	6	,	,	PUNCT
admet-830	309	7	d.	d.	PROPN
admet-830	309	8	shukla	shukla	PROPN
admet-830	309	9	,	,	PUNCT
admet-830	309	10	b.	b.	PROPN
admet-830	309	11	mishra	mishra	PROPN
admet-830	309	12	,	,	PUNCT
admet-830	309	13	s.	s.	PROPN
admet-830	309	14	singh	singh	PROPN
admet-830	309	15	.	.	PUNCT
admet-830	310	1	lipid	lipid	PROPN
admet-830	310	2	–	–	PUNCT
admet-830	310	3	an	an	DET
admet-830	310	4	emerging	emerge	VERB
admet-830	310	5	platform	platform	NOUN
admet-830	310	6	for	for	ADP
admet-830	310	7	oral	oral	ADJ
admet-830	310	8	delivery	delivery	NOUN
admet-830	310	9	of	of	ADP
admet-830	310	10	drugs	drug	NOUN
admet-830	310	11	with	with	ADP
admet-830	310	12	poor	poor	ADJ
admet-830	310	13	bioavailability	bioavailability	NOUN
admet-830	310	14	.	.	PUNCT
admet-830	311	1	european	european	PROPN
admet-830	311	2	journal	journal	PROPN
admet-830	311	3	of	of	ADP
admet-830	311	4	pharmaceutics	pharmaceutic	NOUN
admet-830	311	5	and	and	CCONJ
admet-830	311	6	biopharmaceutics	biopharmaceutic	NOUN
admet-830	311	7	73	73	NUM
admet-830	311	8	(	(	PUNCT
admet-830	311	9	2009	2009	NUM
admet-830	311	10	)	)	PUNCT
admet-830	311	11	1	1	NUM
admet-830	311	12	-	-	SYM
admet-830	311	13	15	15	NUM
admet-830	311	14	.	.	PUNCT
admet-830	312	1	[	[	X
admet-830	312	2	30	30	NUM
admet-830	312	3	]	]	X
admet-830	312	4	a.t	a.t	PROPN
admet-830	312	5	.	.	PROPN
admet-830	312	6	larsen	larsen	PROPN
admet-830	312	7	,	,	PUNCT
admet-830	312	8	a.g	a.g	PROPN
admet-830	312	9	.	.	PROPN
admet-830	312	10	ohlsson	ohlsson	PROPN
admet-830	312	11	,	,	PUNCT
admet-830	312	12	b.	b.	PROPN
admet-830	312	13	polentarutti	polentarutti	PROPN
admet-830	312	14	,	,	PUNCT
admet-830	312	15	r.a	r.a	PROPN
admet-830	312	16	.	.	PROPN
admet-830	312	17	barker	barker	PROPN
admet-830	312	18	,	,	PUNCT
admet-830	312	19	a.r	a.r	PROPN
admet-830	312	20	.	.	PROPN
admet-830	312	21	phillips	phillips	PROPN
admet-830	312	22	,	,	PUNCT
admet-830	312	23	r.	r.	PROPN
admet-830	312	24	abu	abu	PROPN
admet-830	312	25	-	-	PUNCT
admet-830	312	26	rmaileh	rmaileh	PROPN
admet-830	312	27	,	,	PUNCT
admet-830	312	28	p.a	p.a	PROPN
admet-830	312	29	.	.	PROPN
admet-830	312	30	dickinson	dickinson	PROPN
admet-830	312	31	,	,	PUNCT
admet-830	312	32	b.	b.	PROPN
admet-830	312	33	abrahamsson	abrahamsson	PROPN
admet-830	312	34	,	,	PUNCT
admet-830	312	35	j.	j.	PROPN
admet-830	312	36	østergaard	østergaard	PROPN
admet-830	312	37	,	,	PUNCT
admet-830	312	38	a.	a.	NOUN
admet-830	312	39	müllertz	müllertz	PROPN
admet-830	312	40	.	.	PUNCT
admet-830	313	1	oral	oral	ADJ
admet-830	313	2	bioavailability	bioavailability	NOUN
admet-830	313	3	of	of	ADP
admet-830	313	4	cinnarizine	cinnarizine	NOUN
admet-830	313	5	in	in	ADP
admet-830	313	6	dogs	dog	NOUN
admet-830	313	7	:	:	PUNCT
admet-830	313	8	relation	relation	NOUN
admet-830	313	9	to	to	PART
admet-830	313	10	snedds	snedd	VERB
admet-830	313	11	droplet	droplet	ADJ
admet-830	313	12	size	size	NOUN
admet-830	313	13	,	,	PUNCT
admet-830	313	14	drug	drug	NOUN
admet-830	313	15	solubility	solubility	NOUN
admet-830	313	16	and	and	CCONJ
admet-830	313	17	in	in	ADP
admet-830	313	18	vitro	vitro	X
admet-830	313	19	precipitation	precipitation	NOUN
admet-830	313	20	.	.	PUNCT
admet-830	314	1	european	european	ADJ
admet-830	314	2	journal	journal	PROPN
admet-830	314	3	of	of	ADP
admet-830	314	4	pharmaceutical	pharmaceutical	PROPN
admet-830	314	5	sciences	science	NOUN
admet-830	314	6	48	48	NUM
admet-830	314	7	(	(	PUNCT
admet-830	314	8	2013	2013	NUM
admet-830	314	9	)	)	PUNCT
admet-830	314	10	339	339	NUM
admet-830	314	11	-	-	SYM
admet-830	314	12	350	350	NUM
admet-830	314	13	.	.	PUNCT
admet-830	315	1	[	[	X
admet-830	315	2	31	31	NUM
admet-830	315	3	]	]	X
admet-830	315	4	p.j	p.j	PROPN
admet-830	315	5	.	.	PROPN
admet-830	315	6	sassene	sassene	PROPN
admet-830	315	7	,	,	PUNCT
admet-830	315	8	m.h	m.h	PROPN
admet-830	315	9	.	.	PROPN
admet-830	315	10	michaelsen	michaelsen	PROPN
admet-830	315	11	,	,	PUNCT
admet-830	315	12	m.d	m.d	PROPN
admet-830	315	13	.	.	PROPN
admet-830	315	14	mosgaard	mosgaard	PROPN
admet-830	315	15	,	,	PUNCT
admet-830	315	16	m.k	m.k	PROPN
admet-830	315	17	.	.	PUNCT
admet-830	315	18	jensen	jensen	PROPN
admet-830	315	19	,	,	PUNCT
admet-830	315	20	e.	e.	PROPN
admet-830	315	21	van	van	PROPN
admet-830	315	22	den	den	PROPN
admet-830	315	23	broek	broek	PROPN
admet-830	315	24	,	,	PUNCT
admet-830	315	25	k.m	k.m	PROPN
admet-830	315	26	.	.	PROPN
admet-830	315	27	wasan	wasan	PROPN
admet-830	315	28	,	,	PUNCT
admet-830	315	29	h.	h.	PROPN
admet-830	315	30	mu	mu	PROPN
admet-830	315	31	,	,	PUNCT
admet-830	315	32	t.	t.	PROPN
admet-830	315	33	rades	rades	PROPN
admet-830	315	34	,	,	PUNCT
admet-830	315	35	a.	a.	NOUN
admet-830	315	36	müllertz	müllertz	NOUN
admet-830	315	37	.	.	PUNCT
admet-830	316	1	in	in	ADP
admet-830	316	2	vivo	vivo	ADJ
admet-830	316	3	precipitation	precipitation	NOUN
admet-830	316	4	of	of	ADP
admet-830	316	5	poorly	poorly	ADV
admet-830	316	6	soluble	soluble	ADJ
admet-830	316	7	drugs	drug	NOUN
admet-830	316	8	from	from	ADP
admet-830	316	9	lipid	lipid	NOUN
admet-830	316	10	-	-	PUNCT
admet-830	316	11	based	base	VERB
admet-830	316	12	drug	drug	NOUN
admet-830	316	13	delivery	delivery	NOUN
admet-830	316	14	systems	system	NOUN
admet-830	316	15	.	.	PUNCT
admet-830	317	1	molecular	molecular	ADJ
admet-830	317	2	pharmaceutics	pharmaceutic	NOUN
admet-830	317	3	13	13	NUM
admet-830	317	4	(	(	PUNCT
admet-830	317	5	2016	2016	NUM
admet-830	317	6	)	)	PUNCT
admet-830	317	7	3417	3417	NUM
admet-830	317	8	-	-	SYM
admet-830	317	9	3426	3426	NUM
admet-830	317	10	.	.	PUNCT
admet-830	318	1	[	[	X
admet-830	318	2	32	32	NUM
admet-830	318	3	]	]	X
admet-830	318	4	n.	n.	PROPN
admet-830	318	5	thomas	thomas	PROPN
admet-830	318	6	,	,	PUNCT
admet-830	318	7	k.	k.	PROPN
admet-830	318	8	richter	richter	PROPN
admet-830	318	9	,	,	PUNCT
admet-830	318	10	t.b	t.b	PROPN
admet-830	318	11	.	.	PROPN
admet-830	318	12	pedersen	pedersen	PROPN
admet-830	318	13	,	,	PUNCT
admet-830	318	14	r.	r.	PROPN
admet-830	318	15	holm	holm	PROPN
admet-830	318	16	,	,	PUNCT
admet-830	318	17	a.	a.	NOUN
admet-830	318	18	müllertz	müllertz	NOUN
admet-830	318	19	,	,	PUNCT
admet-830	318	20	t.	t.	PROPN
admet-830	318	21	rades	rade	NOUN
admet-830	318	22	.	.	PUNCT
admet-830	319	1	in	in	ADP
admet-830	319	2	vitro	vitro	X
admet-830	319	3	lipolysis	lipolysis	NOUN
admet-830	319	4	data	datum	NOUN
admet-830	319	5	does	do	AUX
admet-830	319	6	not	not	PART
admet-830	319	7	adequately	adequately	ADV
admet-830	319	8	predict	predict	VERB
admet-830	319	9	the	the	DET
admet-830	319	10	in	in	ADP
admet-830	319	11	vivo	vivo	ADJ
admet-830	319	12	performance	performance	NOUN
admet-830	319	13	of	of	ADP
admet-830	319	14	lipid	lipid	NOUN
admet-830	319	15	-	-	PUNCT
admet-830	319	16	based	base	VERB
admet-830	319	17	drug	drug	NOUN
admet-830	319	18	delivery	delivery	NOUN
admet-830	319	19	systems	system	NOUN
admet-830	319	20	containing	contain	VERB
admet-830	319	21	fenofibrate	fenofibrate	NOUN
admet-830	319	22	.	.	PUNCT
admet-830	320	1	the	the	DET
admet-830	320	2	aaps	aaps	PROPN
admet-830	320	3	journal	journal	PROPN
admet-830	320	4	16	16	NUM
admet-830	320	5	(	(	PUNCT
admet-830	320	6	2014	2014	NUM
admet-830	320	7	)	)	PUNCT
admet-830	320	8	539	539	NUM
admet-830	320	9	-	-	SYM
admet-830	320	10	549	549	NUM
admet-830	320	11	.	.	PUNCT
admet-830	321	1	[	[	X
admet-830	321	2	33	33	NUM
admet-830	321	3	]	]	PUNCT
admet-830	321	4	p.	p.	PROPN
admet-830	321	5	joyce	joyce	PROPN
admet-830	321	6	,	,	PUNCT
admet-830	321	7	c.p	c.p	PROPN
admet-830	321	8	.	.	PROPN
admet-830	321	9	whitby	whitby	PROPN
admet-830	321	10	,	,	PUNCT
admet-830	321	11	c.a	c.a	PROPN
admet-830	321	12	.	.	PROPN
admet-830	321	13	prestidge	prestidge	PROPN
admet-830	321	14	.	.	PUNCT
admet-830	322	1	nanostructuring	nanostructure	VERB
admet-830	322	2	biomaterials	biomaterial	NOUN
admet-830	322	3	with	with	ADP
admet-830	322	4	specific	specific	ADJ
admet-830	322	5	activities	activity	NOUN
admet-830	322	6	towards	towards	ADP
admet-830	322	7	digestive	digestive	ADJ
admet-830	322	8	enzymes	enzyme	NOUN
admet-830	322	9	for	for	ADP
admet-830	322	10	controlled	control	VERB
admet-830	322	11	gastrointestinal	gastrointestinal	ADJ
admet-830	322	12	absorption	absorption	NOUN
admet-830	322	13	of	of	ADP
admet-830	322	14	lipophilic	lipophilic	ADJ
admet-830	322	15	bioactive	bioactive	ADJ
admet-830	322	16	molecules	molecule	NOUN
admet-830	322	17	.	.	PUNCT
admet-830	323	1	advances	advance	NOUN
admet-830	323	2	in	in	ADP
admet-830	323	3	colloid	colloid	NOUN
admet-830	323	4	and	and	CCONJ
admet-830	323	5	interface	interface	NOUN
admet-830	323	6	science	science	NOUN
admet-830	323	7	237	237	NUM
admet-830	323	8	(	(	PUNCT
admet-830	323	9	2016	2016	NUM
admet-830	323	10	)	)	PUNCT
admet-830	323	11	52	52	NUM
admet-830	323	12	-	-	SYM
admet-830	323	13	75	75	NUM
admet-830	323	14	.	.	PUNCT
admet-830	324	1	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	324	2	admet	admet	PROPN
admet-830	324	3	&	&	CCONJ
admet-830	324	4	dmpk	dmpk	PROPN
admet-830	324	5	8(4	8(4	NOUN
admet-830	324	6	)	)	PUNCT
admet-830	324	7	(	(	PUNCT
admet-830	324	8	2020	2020	NUM
admet-830	324	9	)	)	PUNCT
admet-830	324	10	437	437	NUM
admet-830	324	11	-	-	SYM
admet-830	324	12	451	451	NUM
admet-830	324	13	drug	drug	NOUN
admet-830	324	14	ionisation	ionisation	NOUN
admet-830	324	15	and	and	CCONJ
admet-830	324	16	lipid	lipid	NOUN
admet-830	324	17	-	-	PUNCT
admet-830	324	18	based	base	VERB
admet-830	324	19	formulations	formulation	NOUN
admet-830	324	20	doi	doi	NOUN
admet-830	324	21	:	:	PUNCT
admet-830	324	22	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	324	23	451	451	NUM
admet-830	325	1	[	[	X
admet-830	325	2	34	34	NUM
admet-830	325	3	]	]	X
admet-830	325	4	t.j	t.j	PROPN
admet-830	325	5	.	.	PROPN
admet-830	325	6	dening	dening	PROPN
admet-830	325	7	,	,	PUNCT
admet-830	325	8	s.	s.	PROPN
admet-830	325	9	rao	rao	PROPN
admet-830	325	10	,	,	PUNCT
admet-830	325	11	n.	n.	PROPN
admet-830	325	12	thomas	thomas	PROPN
admet-830	325	13	,	,	PUNCT
admet-830	325	14	c.a	c.a	PROPN
admet-830	325	15	.	.	PROPN
admet-830	325	16	prestidge	prestidge	PROPN
admet-830	325	17	.	.	PUNCT
admet-830	326	1	montmorillonite	montmorillonite	ADJ
admet-830	326	2	-	-	PUNCT
admet-830	326	3	lipid	lipid	NOUN
admet-830	326	4	hybrid	hybrid	ADJ
admet-830	326	5	carriers	carrier	NOUN
admet-830	326	6	for	for	ADP
admet-830	326	7	ionizable	ionizable	ADJ
admet-830	326	8	and	and	CCONJ
admet-830	326	9	neutral	neutral	ADJ
admet-830	326	10	poorly	poorly	ADV
admet-830	326	11	water	water	NOUN
admet-830	326	12	-	-	PUNCT
admet-830	326	13	soluble	soluble	ADJ
admet-830	326	14	drugs	drug	NOUN
admet-830	326	15	:	:	PUNCT
admet-830	326	16	formulation	formulation	NOUN
admet-830	326	17	,	,	PUNCT
admet-830	326	18	characterization	characterization	NOUN
admet-830	326	19	and	and	CCONJ
admet-830	326	20	in	in	ADP
admet-830	326	21	vitro	vitro	X
admet-830	326	22	lipolysis	lipolysis	NOUN
admet-830	326	23	studies	study	NOUN
admet-830	326	24	.	.	PUNCT
admet-830	327	1	international	international	ADJ
admet-830	327	2	journal	journal	PROPN
admet-830	327	3	of	of	ADP
admet-830	327	4	pharmaceutics	pharmaceutic	NOUN
admet-830	327	5	526	526	NUM
admet-830	327	6	(	(	PUNCT
admet-830	327	7	2017	2017	NUM
admet-830	327	8	)	)	PUNCT
admet-830	327	9	95	95	NUM
admet-830	327	10	-	-	SYM
admet-830	327	11	105	105	NUM
admet-830	327	12	.	.	PUNCT
admet-830	328	1	[	[	X
admet-830	328	2	35	35	NUM
admet-830	328	3	]	]	X
admet-830	328	4	t.j	t.j	PROPN
admet-830	328	5	.	.	PROPN
admet-830	328	6	dening	dening	PROPN
admet-830	328	7	,	,	PUNCT
admet-830	328	8	n.	n.	PROPN
admet-830	328	9	thomas	thomas	PROPN
admet-830	328	10	,	,	PUNCT
admet-830	328	11	s.	s.	PROPN
admet-830	328	12	rao	rao	PROPN
admet-830	328	13	,	,	PUNCT
admet-830	328	14	c.	c.	PROPN
admet-830	328	15	van	van	PROPN
admet-830	328	16	looveren	looveren	PROPN
admet-830	328	17	,	,	PUNCT
admet-830	328	18	f.	f.	PROPN
admet-830	328	19	cuyckens	cuyckens	PROPN
admet-830	328	20	,	,	PUNCT
admet-830	328	21	r.	r.	PROPN
admet-830	328	22	holm	holm	PROPN
admet-830	328	23	,	,	PUNCT
admet-830	328	24	c.a	c.a	PROPN
admet-830	328	25	.	.	PROPN
admet-830	328	26	prestidge	prestidge	PROPN
admet-830	328	27	.	.	PUNCT
admet-830	328	28	montmorillonite	montmorillonite	ADJ
admet-830	328	29	and	and	CCONJ
admet-830	328	30	laponite	laponite	ADJ
admet-830	328	31	clay	clay	NOUN
admet-830	328	32	materials	material	NOUN
admet-830	328	33	for	for	ADP
admet-830	328	34	the	the	DET
admet-830	328	35	solidification	solidification	NOUN
admet-830	328	36	of	of	ADP
admet-830	328	37	lipid	lipid	NOUN
admet-830	328	38	-	-	PUNCT
admet-830	328	39	based	base	VERB
admet-830	328	40	formulations	formulation	NOUN
admet-830	328	41	for	for	ADP
admet-830	328	42	the	the	DET
admet-830	328	43	basic	basic	ADJ
admet-830	328	44	drug	drug	NOUN
admet-830	328	45	blonanserin	blonanserin	NOUN
admet-830	328	46	:	:	PUNCT
admet-830	328	47	in	in	ADP
admet-830	328	48	vitro	vitro	X
admet-830	328	49	and	and	CCONJ
admet-830	328	50	in	in	ADP
admet-830	328	51	vivo	vivo	ADJ
admet-830	328	52	investigations	investigation	NOUN
admet-830	328	53	.	.	PUNCT
admet-830	329	1	molecular	molecular	ADJ
admet-830	329	2	pharmaceutics	pharmaceutic	NOUN
admet-830	329	3	15	15	NUM
admet-830	329	4	(	(	PUNCT
admet-830	329	5	2018	2018	NUM
admet-830	329	6	)	)	PUNCT
admet-830	329	7	41484160	41484160	NUM
admet-830	329	8	.	.	PUNCT
admet-830	330	1	[	[	X
admet-830	330	2	36	36	NUM
admet-830	330	3	]	]	X
admet-830	330	4	h.	h.	PROPN
admet-830	330	5	mu	mu	PROPN
admet-830	330	6	,	,	PUNCT
admet-830	330	7	r.	r.	PROPN
admet-830	330	8	holm	holm	PROPN
admet-830	330	9	,	,	PUNCT
admet-830	330	10	a.	a.	NOUN
admet-830	330	11	müllertz	müllertz	NOUN
admet-830	330	12	.	.	PUNCT
admet-830	331	1	lipid	lipid	NOUN
admet-830	331	2	-	-	PUNCT
admet-830	331	3	based	base	VERB
admet-830	331	4	formulations	formulation	NOUN
admet-830	331	5	for	for	ADP
admet-830	331	6	oral	oral	ADJ
admet-830	331	7	administration	administration	NOUN
admet-830	331	8	of	of	ADP
admet-830	331	9	poorly	poorly	ADV
admet-830	331	10	water	water	NOUN
admet-830	331	11	-	-	PUNCT
admet-830	331	12	soluble	soluble	ADJ
admet-830	331	13	drugs	drug	NOUN
admet-830	331	14	.	.	PUNCT
admet-830	332	1	international	international	ADJ
admet-830	332	2	journal	journal	PROPN
admet-830	332	3	of	of	ADP
admet-830	332	4	pharmaceutics	pharmaceutic	NOUN
admet-830	332	5	453	453	NUM
admet-830	332	6	(	(	PUNCT
admet-830	332	7	2013	2013	NUM
admet-830	332	8	)	)	PUNCT
admet-830	332	9	215	215	NUM
admet-830	332	10	-	-	SYM
admet-830	332	11	224	224	NUM
admet-830	332	12	.	.	PUNCT
admet-830	333	1	[	[	X
admet-830	333	2	37	37	NUM
admet-830	333	3	]	]	X
admet-830	333	4	c.w	c.w	PROPN
admet-830	333	5	.	.	PROPN
admet-830	333	6	pouton	pouton	PROPN
admet-830	333	7	.	.	PUNCT
admet-830	334	1	formulation	formulation	NOUN
admet-830	334	2	of	of	ADP
admet-830	334	3	poorly	poorly	ADV
admet-830	334	4	water	water	NOUN
admet-830	334	5	-	-	PUNCT
admet-830	334	6	soluble	soluble	ADJ
admet-830	334	7	drugs	drug	NOUN
admet-830	334	8	for	for	ADP
admet-830	334	9	oral	oral	ADJ
admet-830	334	10	administration	administration	NOUN
admet-830	334	11	:	:	PUNCT
admet-830	334	12	physicochemical	physicochemical	ADJ
admet-830	334	13	and	and	CCONJ
admet-830	334	14	physiological	physiological	ADJ
admet-830	334	15	issues	issue	NOUN
admet-830	334	16	and	and	CCONJ
admet-830	334	17	the	the	DET
admet-830	334	18	lipid	lipid	NOUN
admet-830	334	19	formulation	formulation	NOUN
admet-830	334	20	classification	classification	NOUN
admet-830	334	21	system	system	NOUN
admet-830	334	22	.	.	PUNCT
admet-830	335	1	european	european	PROPN
admet-830	335	2	journal	journal	PROPN
admet-830	335	3	of	of	ADP
admet-830	335	4	pharmaceutical	pharmaceutical	PROPN
admet-830	335	5	sciences	science	NOUN
admet-830	335	6	29	29	NUM
admet-830	335	7	(	(	PUNCT
admet-830	335	8	2006	2006	NUM
admet-830	335	9	)	)	PUNCT
admet-830	335	10	278	278	NUM
admet-830	335	11	-	-	SYM
admet-830	335	12	287	287	NUM
admet-830	335	13	.	.	PUNCT
admet-830	336	1	©	©	PROPN
admet-830	336	2	2020	2020	NUM
admet-830	336	3	by	by	ADP
admet-830	336	4	the	the	DET
admet-830	336	5	authors	author	NOUN
admet-830	336	6	;	;	PUNCT
admet-830	336	7	licensee	licensee	PROPN
admet-830	336	8	iapc	iapc	PROPN
admet-830	336	9	,	,	PUNCT
admet-830	336	10	zagreb	zagreb	PROPN
admet-830	336	11	,	,	PUNCT
admet-830	336	12	croatia	croatia	PROPN
admet-830	336	13	.	.	PUNCT
admet-830	337	1	this	this	DET
admet-830	337	2	article	article	NOUN
admet-830	337	3	is	be	AUX
admet-830	337	4	an	an	DET
admet-830	337	5	open	open	ADJ
admet-830	337	6	-	-	PUNCT
admet-830	337	7	access	access	NOUN
admet-830	337	8	article	article	NOUN
admet-830	337	9	distributed	distribute	VERB
admet-830	337	10	under	under	ADP
admet-830	337	11	the	the	DET
admet-830	337	12	terms	term	NOUN
admet-830	337	13	and	and	CCONJ
admet-830	337	14	conditions	condition	NOUN
admet-830	337	15	of	of	ADP
admet-830	337	16	the	the	DET
admet-830	337	17	creative	creative	ADJ
admet-830	337	18	commons	common	NOUN
admet-830	337	19	attribution	attribution	NOUN
admet-830	337	20	license	license	NOUN
admet-830	337	21	(	(	PUNCT
admet-830	337	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	NOUN
admet-830	337	23	)	)	PUNCT
admet-830	337	24	https://dx.doi.org/10.5599/admet.830	https://dx.doi.org/10.5599/admet.830	NOUN
admet-830	337	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN