id	sid	tid	token	lemma	pos
admet-831	1	1	solubility	solubility	NOUN
admet-831	1	2	of	of	ADP
admet-831	1	3	proteins	protein	NOUN
admet-831	1	4	doi	doi	NOUN
admet-831	1	5	:	:	PUNCT
admet-831	1	6	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PROPN
admet-831	1	7	391	391	NUM
admet-831	1	8	admet	admet	X
admet-831	1	9	&	&	CCONJ
admet-831	1	10	dmpk	dmpk	PROPN
admet-831	1	11	8(4	8(4	NOUN
admet-831	1	12	)	)	PUNCT
admet-831	1	13	(	(	PUNCT
admet-831	1	14	2020	2020	NUM
admet-831	1	15	)	)	PUNCT
admet-831	1	16	391	391	NUM
admet-831	1	17	-	-	SYM
admet-831	1	18	399	399	NUM
admet-831	1	19	;	;	PUNCT
admet-831	1	20	doi	doi	NOUN
admet-831	1	21	:	:	PUNCT
admet-831	1	22	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	X
admet-831	1	23	open	open	ADJ
admet-831	1	24	access	access	NOUN
admet-831	1	25	:	:	PUNCT
admet-831	1	26	issn	issn	PROPN
admet-831	1	27	:	:	PUNCT
admet-831	1	28	1848	1848	NUM
admet-831	1	29	-	-	SYM
admet-831	1	30	7718	7718	NUM
admet-831	1	31	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-831	1	32	feature	feature	NOUN
admet-831	1	33	article	article	NOUN
admet-831	1	34	solubility	solubility	NOUN
admet-831	1	35	of	of	ADP
admet-831	1	36	proteins	protein	NOUN
admet-831	1	37	mauno	mauno	PROPN
admet-831	1	38	vihinen	vihinen	PROPN
admet-831	1	39	*	*	NOUN
admet-831	1	40	protein	protein	NOUN
admet-831	1	41	structure	structure	NOUN
admet-831	1	42	and	and	CCONJ
admet-831	1	43	bioinformatics	bioinformatics	NOUN
admet-831	1	44	,	,	PUNCT
admet-831	1	45	department	department	NOUN
admet-831	1	46	of	of	ADP
admet-831	1	47	experimental	experimental	ADJ
admet-831	1	48	medical	medical	ADJ
admet-831	1	49	science	science	NOUN
admet-831	1	50	,	,	PUNCT
admet-831	1	51	bmc	bmc	NOUN
admet-831	1	52	b13	b13	NOUN
admet-831	1	53	,	,	PUNCT
admet-831	1	54	se-22184	se-22184	PROPN
admet-831	1	55	lund	lund	PROPN
admet-831	1	56	,	,	PUNCT
admet-831	1	57	sweden	sweden	PROPN
admet-831	1	58	*	*	PUNCT
admet-831	1	59	corresponding	correspond	VERB
admet-831	1	60	author	author	NOUN
admet-831	1	61	:	:	PUNCT
admet-831	1	62	e	e	NOUN
admet-831	1	63	-	-	NOUN
admet-831	1	64	mail	mail	NOUN
admet-831	1	65	:	:	PUNCT
admet-831	1	66	mauno.vihinen@med.lu.se	mauno.vihinen@med.lu.se	ADJ
admet-831	1	67	;	;	PUNCT
admet-831	1	68	tel	tel	PROPN
admet-831	1	69	.	.	PUNCT
admet-831	1	70	:	:	PUNCT
admet-831	2	1	+46	+46	NUM
admet-831	2	2	-	-	PUNCT
admet-831	2	3	72	72	NUM
admet-831	2	4	-	-	PUNCT
admet-831	2	5	5260022	5260022	NUM
admet-831	2	6	received	receive	VERB
admet-831	2	7	:	:	PUNCT
admet-831	2	8	april	april	PROPN
admet-831	2	9	24	24	NUM
admet-831	2	10	,	,	PUNCT
admet-831	2	11	2020	2020	NUM
admet-831	2	12	;	;	PUNCT
admet-831	2	13	revised	revise	VERB
admet-831	2	14	:	:	PUNCT
admet-831	2	15	june	june	PROPN
admet-831	2	16	18	18	NUM
admet-831	2	17	,	,	PUNCT
admet-831	2	18	2020	2020	NUM
admet-831	2	19	;	;	PUNCT
admet-831	2	20	published	publish	VERB
admet-831	2	21	:	:	PUNCT
admet-831	2	22	june	june	PROPN
admet-831	2	23	28	28	NUM
admet-831	2	24	,	,	PUNCT
admet-831	2	25	2020	2020	NUM
admet-831	2	26	abstract	abstract	ADJ
admet-831	2	27	solubility	solubility	NOUN
admet-831	2	28	is	be	AUX
admet-831	2	29	a	a	DET
admet-831	2	30	fundamental	fundamental	ADJ
admet-831	2	31	protein	protein	NOUN
admet-831	2	32	property	property	NOUN
admet-831	2	33	that	that	PRON
admet-831	2	34	has	have	VERB
admet-831	2	35	important	important	ADJ
admet-831	2	36	connotations	connotation	NOUN
admet-831	2	37	for	for	ADP
admet-831	2	38	therapeutics	therapeutic	NOUN
admet-831	2	39	and	and	CCONJ
admet-831	2	40	use	use	NOUN
admet-831	2	41	in	in	ADP
admet-831	2	42	diagnosis	diagnosis	NOUN
admet-831	2	43	.	.	PUNCT
admet-831	3	1	solubility	solubility	NOUN
admet-831	3	2	of	of	ADP
admet-831	3	3	many	many	ADJ
admet-831	3	4	proteins	protein	NOUN
admet-831	3	5	is	be	AUX
admet-831	3	6	low	low	ADJ
admet-831	3	7	and	and	CCONJ
admet-831	3	8	affect	affect	VERB
admet-831	3	9	heterologous	heterologous	ADJ
admet-831	3	10	overexpression	overexpression	NOUN
admet-831	3	11	of	of	ADP
admet-831	3	12	proteins	protein	NOUN
admet-831	3	13	,	,	PUNCT
admet-831	3	14	formulation	formulation	NOUN
admet-831	3	15	of	of	ADP
admet-831	3	16	products	product	NOUN
admet-831	3	17	and	and	CCONJ
admet-831	3	18	their	their	PRON
admet-831	3	19	stability	stability	NOUN
admet-831	3	20	.	.	PUNCT
admet-831	4	1	two	two	NUM
admet-831	4	2	processes	process	NOUN
admet-831	4	3	are	be	AUX
admet-831	4	4	related	relate	VERB
admet-831	4	5	to	to	ADP
admet-831	4	6	soluble	soluble	ADJ
admet-831	4	7	and	and	CCONJ
admet-831	4	8	solid	solid	ADJ
admet-831	4	9	phase	phase	NOUN
admet-831	4	10	relations	relation	NOUN
admet-831	4	11	.	.	PUNCT
admet-831	5	1	solubility	solubility	NOUN
admet-831	5	2	refers	refer	VERB
admet-831	5	3	to	to	ADP
admet-831	5	4	the	the	DET
admet-831	5	5	process	process	NOUN
admet-831	5	6	where	where	SCONJ
admet-831	5	7	proteins	protein	NOUN
admet-831	5	8	have	have	VERB
admet-831	5	9	correctly	correctly	ADV
admet-831	5	10	folded	fold	VERB
admet-831	5	11	structure	structure	NOUN
admet-831	5	12	,	,	PUNCT
admet-831	5	13	whereas	whereas	SCONJ
admet-831	5	14	aggregation	aggregation	NOUN
admet-831	5	15	is	be	AUX
admet-831	5	16	related	relate	VERB
admet-831	5	17	to	to	ADP
admet-831	5	18	the	the	DET
admet-831	5	19	formation	formation	NOUN
admet-831	5	20	of	of	ADP
admet-831	5	21	fibrils	fibril	NOUN
admet-831	5	22	,	,	PUNCT
admet-831	5	23	oligomers	oligomer	NOUN
admet-831	5	24	or	or	CCONJ
admet-831	5	25	amorphous	amorphous	ADJ
admet-831	5	26	particles	particle	NOUN
admet-831	5	27	.	.	PUNCT
admet-831	6	1	both	both	DET
admet-831	6	2	processes	process	NOUN
admet-831	6	3	are	be	AUX
admet-831	6	4	related	relate	VERB
admet-831	6	5	to	to	ADP
admet-831	6	6	some	some	DET
admet-831	6	7	diseases	disease	NOUN
admet-831	6	8	.	.	PUNCT
admet-831	7	1	amyloid	amyloid	NOUN
admet-831	7	2	fibril	fibril	ADJ
admet-831	7	3	formation	formation	NOUN
admet-831	7	4	is	be	AUX
admet-831	7	5	one	one	NUM
admet-831	7	6	of	of	ADP
admet-831	7	7	the	the	DET
admet-831	7	8	characteristic	characteristic	ADJ
admet-831	7	9	features	feature	NOUN
admet-831	7	10	in	in	ADP
admet-831	7	11	several	several	ADJ
admet-831	7	12	neurodegenerative	neurodegenerative	ADJ
admet-831	7	13	diseases	disease	NOUN
admet-831	7	14	,	,	PUNCT
admet-831	7	15	but	but	CCONJ
admet-831	7	16	it	it	PRON
admet-831	7	17	is	be	AUX
admet-831	7	18	related	relate	VERB
admet-831	7	19	to	to	ADP
admet-831	7	20	many	many	ADJ
admet-831	7	21	other	other	ADJ
admet-831	7	22	diseases	disease	NOUN
admet-831	7	23	,	,	PUNCT
admet-831	7	24	including	include	VERB
admet-831	7	25	cancers	cancer	NOUN
admet-831	7	26	.	.	PUNCT
admet-831	8	1	severe	severe	ADJ
admet-831	8	2	complex	complex	ADJ
admet-831	8	3	v	v	NOUN
admet-831	8	4	deficiency	deficiency	NOUN
admet-831	8	5	and	and	CCONJ
admet-831	8	6	cataract	cataract	NOUN
admet-831	8	7	are	be	AUX
admet-831	8	8	examples	example	NOUN
admet-831	8	9	of	of	ADP
admet-831	8	10	diseases	disease	NOUN
admet-831	8	11	due	due	ADJ
admet-831	8	12	to	to	ADP
admet-831	8	13	reduced	reduce	VERB
admet-831	8	14	protein	protein	NOUN
admet-831	8	15	solubility	solubility	NOUN
admet-831	8	16	.	.	PUNCT
admet-831	9	1	methods	method	NOUN
admet-831	9	2	and	and	CCONJ
admet-831	9	3	approaches	approach	NOUN
admet-831	9	4	are	be	AUX
admet-831	9	5	described	describe	VERB
admet-831	9	6	for	for	ADP
admet-831	9	7	prediction	prediction	NOUN
admet-831	9	8	of	of	ADP
admet-831	9	9	protein	protein	NOUN
admet-831	9	10	solubility	solubility	NOUN
admet-831	9	11	and	and	CCONJ
admet-831	9	12	aggregation	aggregation	NOUN
admet-831	9	13	,	,	PUNCT
admet-831	9	14	as	as	ADV
admet-831	9	15	well	well	ADV
admet-831	9	16	as	as	ADP
admet-831	9	17	predictions	prediction	NOUN
admet-831	9	18	of	of	ADP
admet-831	9	19	consequences	consequence	NOUN
admet-831	9	20	of	of	ADP
admet-831	9	21	amino	amino	NOUN
admet-831	9	22	acid	acid	NOUN
admet-831	9	23	substitutions	substitution	NOUN
admet-831	9	24	.	.	PUNCT
admet-831	10	1	finally	finally	ADV
admet-831	10	2	,	,	PUNCT
admet-831	10	3	protein	protein	NOUN
admet-831	10	4	engineering	engineering	NOUN
admet-831	10	5	solutions	solution	NOUN
admet-831	10	6	are	be	AUX
admet-831	10	7	discussed	discuss	VERB
admet-831	10	8	.	.	PUNCT
admet-831	11	1	protein	protein	NOUN
admet-831	11	2	solubility	solubility	NOUN
admet-831	11	3	can	can	AUX
admet-831	11	4	be	be	AUX
admet-831	11	5	increased	increase	VERB
admet-831	11	6	,	,	PUNCT
admet-831	11	7	although	although	SCONJ
admet-831	11	8	such	such	ADJ
admet-831	11	9	alterations	alteration	NOUN
admet-831	11	10	are	be	AUX
admet-831	11	11	relatively	relatively	ADV
admet-831	11	12	rare	rare	ADJ
admet-831	11	13	and	and	CCONJ
admet-831	11	14	can	can	AUX
admet-831	11	15	lead	lead	VERB
admet-831	11	16	to	to	ADP
admet-831	11	17	trade	trade	NOUN
admet-831	11	18	-	-	PUNCT
admet-831	11	19	off	off	NOUN
admet-831	11	20	with	with	ADP
admet-831	11	21	some	some	DET
admet-831	11	22	other	other	ADJ
admet-831	11	23	properties	property	NOUN
admet-831	11	24	.	.	PUNCT
admet-831	12	1	the	the	DET
admet-831	12	2	aggregation	aggregation	NOUN
admet-831	12	3	prediction	prediction	NOUN
admet-831	12	4	methods	method	NOUN
admet-831	12	5	mainly	mainly	ADV
admet-831	12	6	aim	aim	VERB
admet-831	12	7	to	to	PART
admet-831	12	8	detect	detect	VERB
admet-831	12	9	aggregation	aggregation	NOUN
admet-831	12	10	-	-	PUNCT
admet-831	12	11	prone	prone	ADJ
admet-831	12	12	sequence	sequence	NOUN
admet-831	12	13	patches	patch	NOUN
admet-831	12	14	and	and	CCONJ
admet-831	12	15	then	then	ADV
admet-831	12	16	making	make	VERB
admet-831	12	17	them	they	PRON
admet-831	12	18	more	more	ADV
admet-831	12	19	soluble	soluble	ADJ
admet-831	12	20	.	.	PUNCT
admet-831	13	1	the	the	DET
admet-831	13	2	solubility	solubility	NOUN
admet-831	13	3	predictors	predictor	NOUN
admet-831	13	4	utilize	utilize	VERB
admet-831	13	5	a	a	DET
admet-831	13	6	wide	wide	ADJ
admet-831	13	7	spectrum	spectrum	NOUN
admet-831	13	8	of	of	ADP
admet-831	13	9	features	feature	NOUN
admet-831	13	10	.	.	PUNCT
admet-831	14	1	©	©	PROPN
admet-831	14	2	2020	2020	NUM
admet-831	14	3	by	by	ADP
admet-831	14	4	the	the	DET
admet-831	14	5	authors	author	NOUN
admet-831	14	6	.	.	PUNCT
admet-831	15	1	this	this	DET
admet-831	15	2	article	article	NOUN
admet-831	15	3	is	be	AUX
admet-831	15	4	an	an	DET
admet-831	15	5	open	open	ADJ
admet-831	15	6	-	-	PUNCT
admet-831	15	7	access	access	NOUN
admet-831	15	8	article	article	NOUN
admet-831	15	9	distributed	distribute	VERB
admet-831	15	10	under	under	ADP
admet-831	15	11	the	the	DET
admet-831	15	12	terms	term	NOUN
admet-831	15	13	and	and	CCONJ
admet-831	15	14	conditions	condition	NOUN
admet-831	15	15	of	of	ADP
admet-831	15	16	the	the	DET
admet-831	15	17	creative	creative	ADJ
admet-831	15	18	commons	common	NOUN
admet-831	15	19	attribution	attribution	NOUN
admet-831	15	20	license	license	NOUN
admet-831	15	21	(	(	PUNCT
admet-831	15	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-831	15	23	)	)	PUNCT
admet-831	15	24	.	.	PUNCT
admet-831	16	1	keywords	keyword	VERB
admet-831	16	2	aggregation	aggregation	NOUN
admet-831	16	3	;	;	PUNCT
admet-831	16	4	protein	protein	NOUN
admet-831	16	5	engineering	engineering	NOUN
admet-831	16	6	;	;	PUNCT
admet-831	16	7	biologic	biologic	NOUN
admet-831	16	8	;	;	PUNCT
admet-831	16	9	solubility	solubility	NOUN
admet-831	16	10	prediction	prediction	NOUN
admet-831	16	11	introduction	introduction	NOUN
admet-831	16	12	solubility	solubility	NOUN
admet-831	16	13	is	be	AUX
admet-831	16	14	an	an	DET
admet-831	16	15	important	important	ADJ
admet-831	16	16	property	property	NOUN
admet-831	16	17	for	for	ADP
admet-831	16	18	all	all	DET
admet-831	16	19	drugs	drug	NOUN
admet-831	16	20	,	,	PUNCT
admet-831	16	21	including	include	VERB
admet-831	16	22	biologics	biologic	NOUN
admet-831	16	23	.	.	PUNCT
admet-831	17	1	many	many	ADJ
admet-831	17	2	proteins	protein	NOUN
admet-831	17	3	and	and	CCONJ
admet-831	17	4	polypeptides	polypeptide	NOUN
admet-831	17	5	are	be	AUX
admet-831	17	6	poorly	poorly	ADV
admet-831	17	7	soluble	soluble	ADJ
admet-831	17	8	and	and	CCONJ
admet-831	17	9	those	those	PRON
admet-831	17	10	trespassing	trespass	VERB
admet-831	17	11	through	through	ADP
admet-831	17	12	cellular	cellular	ADJ
admet-831	17	13	membranes	membrane	NOUN
admet-831	17	14	,	,	PUNCT
admet-831	17	15	membrane	membrane	NOUN
admet-831	17	16	proteins	protein	NOUN
admet-831	17	17	,	,	PUNCT
admet-831	17	18	are	be	AUX
admet-831	17	19	not	not	PART
admet-831	17	20	in	in	ADP
admet-831	17	21	traditional	traditional	ADJ
admet-831	17	22	sense	sense	NOUN
admet-831	17	23	soluble	soluble	ADJ
admet-831	17	24	at	at	ADV
admet-831	17	25	all	all	ADV
admet-831	17	26	.	.	PUNCT
admet-831	18	1	proteome	proteome	VERB
admet-831	18	2	-	-	PUNCT
admet-831	18	3	wide	wide	ADJ
admet-831	18	4	analysis	analysis	NOUN
admet-831	18	5	of	of	ADP
admet-831	18	6	solubility	solubility	NOUN
admet-831	18	7	in	in	ADP
admet-831	18	8	caenorhabditis	caenorhabditis	PROPN
admet-831	18	9	elegans	elegans	PROPN
admet-831	18	10	indicated	indicate	VERB
admet-831	18	11	that	that	SCONJ
admet-831	18	12	about	about	ADV
admet-831	18	13	75	75	NUM
admet-831	18	14	%	%	NOUN
admet-831	18	15	of	of	ADP
admet-831	18	16	proteins	protein	NOUN
admet-831	18	17	appear	appear	VERB
admet-831	18	18	in	in	ADP
admet-831	18	19	cells	cell	NOUN
admet-831	18	20	in	in	ADP
admet-831	18	21	abundances	abundance	NOUN
admet-831	18	22	close	close	ADV
admet-831	18	23	to	to	ADP
admet-831	18	24	their	their	PRON
admet-831	18	25	solubility	solubility	NOUN
admet-831	18	26	limits	limit	NOUN
admet-831	18	27	[	[	X
admet-831	18	28	1	1	NUM
admet-831	18	29	]	]	PUNCT
admet-831	18	30	.	.	PUNCT
admet-831	19	1	we	we	PRON
admet-831	19	2	can	can	AUX
admet-831	19	3	distinguish	distinguish	VERB
admet-831	19	4	two	two	NUM
admet-831	19	5	phenomena	phenomenon	NOUN
admet-831	19	6	in	in	ADP
admet-831	19	7	relation	relation	NOUN
admet-831	19	8	to	to	ADP
admet-831	19	9	protein	protein	NOUN
admet-831	19	10	behaviour	behaviour	NOUN
admet-831	19	11	in	in	ADP
admet-831	19	12	solution	solution	NOUN
admet-831	19	13	.	.	PUNCT
admet-831	20	1	solubility	solubility	NOUN
admet-831	20	2	and	and	CCONJ
admet-831	20	3	aggregation	aggregation	NOUN
admet-831	20	4	are	be	AUX
admet-831	20	5	related	relate	VERB
admet-831	20	6	but	but	CCONJ
admet-831	20	7	have	have	VERB
admet-831	20	8	different	different	ADJ
admet-831	20	9	meanings	meaning	NOUN
admet-831	20	10	.	.	PUNCT
admet-831	21	1	solubility	solubility	NOUN
admet-831	21	2	is	be	AUX
admet-831	21	3	defined	define	VERB
admet-831	21	4	here	here	ADV
admet-831	21	5	and	and	CCONJ
admet-831	21	6	in	in	ADP
admet-831	21	7	many	many	ADJ
admet-831	21	8	other	other	ADJ
admet-831	21	9	publications	publication	NOUN
admet-831	21	10	as	as	ADP
admet-831	21	11	the	the	DET
admet-831	21	12	concentration	concentration	NOUN
admet-831	21	13	in	in	ADP
admet-831	21	14	which	which	PRON
admet-831	21	15	intact	intact	ADJ
admet-831	21	16	protein	protein	NOUN
admet-831	21	17	is	be	AUX
admet-831	21	18	in	in	ADP
admet-831	21	19	equilibrium	equilibrium	NOUN
admet-831	21	20	with	with	ADP
admet-831	21	21	solid	solid	ADJ
admet-831	21	22	phase	phase	NOUN
admet-831	21	23	[	[	X
admet-831	21	24	2	2	NUM
admet-831	21	25	-	-	SYM
admet-831	21	26	4	4	NUM
admet-831	21	27	]	]	PUNCT
admet-831	21	28	.	.	PUNCT
admet-831	22	1	in	in	ADP
admet-831	22	2	the	the	DET
admet-831	22	3	case	case	NOUN
admet-831	22	4	of	of	ADP
admet-831	22	5	aggregation	aggregation	NOUN
admet-831	22	6	,	,	PUNCT
admet-831	22	7	protein	protein	NOUN
admet-831	22	8	molecules	molecule	NOUN
admet-831	22	9	bind	bind	VERB
admet-831	22	10	together	together	ADV
admet-831	22	11	,	,	PUNCT
admet-831	22	12	often	often	ADV
admet-831	22	13	due	due	ADJ
admet-831	22	14	to	to	ADP
admet-831	22	15	irreversibly	irreversibly	ADV
admet-831	22	16	altered	alter	VERB
admet-831	22	17	conformation	conformation	NOUN
admet-831	22	18	,	,	PUNCT
admet-831	22	19	and	and	CCONJ
admet-831	22	20	form	form	VERB
admet-831	22	21	insoluble	insoluble	ADJ
admet-831	22	22	high	high	ADJ
admet-831	22	23	molecular	molecular	ADJ
admet-831	22	24	weight	weight	NOUN
admet-831	22	25	forms	form	NOUN
admet-831	22	26	(	(	PUNCT
admet-831	22	27	see	see	VERB
admet-831	22	28	figure	figure	NOUN
admet-831	22	29	1	1	NUM
admet-831	22	30	)	)	PUNCT
admet-831	23	1	[	[	X
admet-831	23	2	5	5	NUM
admet-831	23	3	]	]	PUNCT
admet-831	23	4	.	.	PUNCT
admet-831	24	1	unlike	unlike	ADP
admet-831	24	2	aggregated	aggregate	VERB
admet-831	24	3	forms	form	NOUN
admet-831	24	4	,	,	PUNCT
admet-831	24	5	precipitated	precipitate	VERB
admet-831	24	6	solubilizable	solubilizable	ADJ
admet-831	24	7	protein	protein	NOUN
admet-831	24	8	in	in	ADP
admet-831	24	9	solid	solid	ADJ
admet-831	24	10	phase	phase	NOUN
admet-831	24	11	can	can	AUX
admet-831	24	12	be	be	AUX
admet-831	24	13	made	make	VERB
admet-831	24	14	soluble	soluble	ADJ
admet-831	24	15	by	by	ADP
admet-831	24	16	dilution	dilution	NOUN
admet-831	24	17	.	.	PUNCT
admet-831	25	1	aggregated	aggregate	VERB
admet-831	25	2	protein	protein	NOUN
admet-831	25	3	is	be	AUX
admet-831	25	4	in	in	ADP
admet-831	25	5	solid	solid	ADJ
admet-831	25	6	phase	phase	NOUN
admet-831	25	7	and	and	CCONJ
admet-831	25	8	typically	typically	ADV
admet-831	25	9	undergoes	undergo	VERB
admet-831	25	10	irreversible	irreversible	ADJ
admet-831	25	11	structural	structural	ADJ
admet-831	25	12	changes	change	NOUN
admet-831	25	13	,	,	PUNCT
admet-831	25	14	thus	thus	ADV
admet-831	25	15	aggregated	aggregate	VERB
admet-831	25	16	protein	protein	NOUN
admet-831	25	17	can	can	AUX
admet-831	25	18	not	not	PART
admet-831	25	19	be	be	AUX
admet-831	25	20	returned	return	VERB
admet-831	25	21	back	back	ADV
admet-831	25	22	to	to	ADP
admet-831	25	23	soluble	soluble	ADJ
admet-831	25	24	form	form	NOUN
admet-831	25	25	and	and	CCONJ
admet-831	25	26	original	original	ADJ
admet-831	25	27	structure	structure	NOUN
admet-831	25	28	.	.	PUNCT
admet-831	26	1	proteins	protein	NOUN
admet-831	26	2	in	in	ADP
admet-831	26	3	these	these	DET
admet-831	26	4	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	NOUN
admet-831	26	5	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PUNCT
admet-831	26	6	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	X
admet-831	26	7	mailto:mauno.vihinen@med.lu.se	mailto:mauno.vihinen@med.lu.se	PROPN
admet-831	26	8	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-831	26	9	mauno	mauno	PROPN
admet-831	26	10	vihinen	vihinen	PROPN
admet-831	26	11	admet	admet	PROPN
admet-831	26	12	&	&	CCONJ
admet-831	26	13	dmpk	dmpk	PROPN
admet-831	26	14	8(4	8(4	NOUN
admet-831	26	15	)	)	PUNCT
admet-831	26	16	(	(	PUNCT
admet-831	26	17	2020	2020	NUM
admet-831	26	18	)	)	PUNCT
admet-831	26	19	391	391	NUM
admet-831	26	20	-	-	SYM
admet-831	26	21	399	399	NUM
admet-831	26	22	392	392	NUM
admet-831	26	23	amyloid	amyloid	NOUN
admet-831	26	24	fibrils	fibril	NOUN
admet-831	26	25	have	have	VERB
admet-831	26	26	extensive	extensive	ADJ
admet-831	26	27	β	β	NOUN
admet-831	26	28	-	-	ADJ
admet-831	26	29	strand	strand	ADJ
admet-831	26	30	secondary	secondary	ADJ
admet-831	26	31	structures	structure	NOUN
admet-831	26	32	.	.	PUNCT
admet-831	27	1	when	when	SCONJ
admet-831	27	2	intrinsically	intrinsically	ADV
admet-831	27	3	disordered	disordered	ADJ
admet-831	27	4	proteins	protein	NOUN
admet-831	27	5	aggregate	aggregate	VERB
admet-831	27	6	they	they	PRON
admet-831	27	7	form	form	VERB
admet-831	27	8	amorphous	amorphous	ADJ
admet-831	27	9	deposits	deposit	NOUN
admet-831	27	10	,	,	PUNCT
admet-831	27	11	whereas	whereas	SCONJ
admet-831	27	12	native	native	ADJ
admet-831	27	13	-	-	PUNCT
admet-831	27	14	like	like	ADJ
admet-831	27	15	structures	structure	NOUN
admet-831	27	16	aggregate	aggregate	VERB
admet-831	27	17	to	to	ADP
admet-831	27	18	native	native	ADJ
admet-831	27	19	-	-	PUNCT
admet-831	27	20	like	like	ADJ
admet-831	27	21	deposits	deposit	NOUN
admet-831	27	22	(	(	PUNCT
admet-831	27	23	figure	figure	NOUN
admet-831	27	24	1	1	NUM
admet-831	27	25	)	)	PUNCT
admet-831	28	1	[	[	X
admet-831	28	2	5	5	NUM
admet-831	28	3	]	]	PUNCT
admet-831	28	4	.	.	PUNCT
admet-831	29	1	both	both	CCONJ
admet-831	29	2	solubility	solubility	NOUN
admet-831	29	3	and	and	CCONJ
admet-831	29	4	aggregation	aggregation	NOUN
admet-831	29	5	have	have	VERB
admet-831	29	6	biological	biological	ADJ
admet-831	29	7	and	and	CCONJ
admet-831	29	8	biotechnological	biotechnological	ADJ
admet-831	29	9	consequences	consequence	NOUN
admet-831	29	10	.	.	PUNCT
admet-831	30	1	reduced	reduce	VERB
admet-831	30	2	solubility	solubility	NOUN
admet-831	30	3	as	as	ADV
admet-831	30	4	well	well	ADV
admet-831	30	5	as	as	ADP
admet-831	30	6	increased	increase	VERB
admet-831	30	7	aggregation	aggregation	NOUN
admet-831	30	8	are	be	AUX
admet-831	30	9	related	relate	VERB
admet-831	30	10	to	to	ADP
admet-831	30	11	several	several	ADJ
admet-831	30	12	diseases	disease	NOUN
admet-831	30	13	.	.	PUNCT
admet-831	31	1	plaques	plaque	NOUN
admet-831	31	2	formed	form	VERB
admet-831	31	3	by	by	ADP
admet-831	31	4	aggregated	aggregate	VERB
admet-831	31	5	proteins	protein	NOUN
admet-831	31	6	are	be	AUX
admet-831	31	7	common	common	ADJ
admet-831	31	8	in	in	ADP
admet-831	31	9	neurodegenerative	neurodegenerative	ADJ
admet-831	31	10	diseases	disease	NOUN
admet-831	31	11	.	.	PUNCT
admet-831	32	1	altered	altered	ADJ
admet-831	32	2	conformations	conformation	NOUN
admet-831	32	3	of	of	ADP
admet-831	32	4	prion	prion	NOUN
admet-831	32	5	proteins	protein	NOUN
admet-831	32	6	can	can	AUX
admet-831	32	7	“	"	PUNCT
admet-831	32	8	infect	infect	VERB
admet-831	32	9	”	"	PUNCT
admet-831	32	10	other	other	ADJ
admet-831	32	11	proteins	protein	NOUN
admet-831	32	12	and	and	CCONJ
admet-831	32	13	cause	cause	VERB
admet-831	32	14	their	their	PRON
admet-831	32	15	aggregation	aggregation	NOUN
admet-831	32	16	.	.	PUNCT
admet-831	33	1	β	β	X
admet-831	33	2	-	-	ADJ
admet-831	33	3	sheet	sheet	NOUN
admet-831	33	4	formation	formation	NOUN
admet-831	33	5	is	be	AUX
admet-831	33	6	often	often	ADV
admet-831	33	7	related	relate	VERB
admet-831	33	8	to	to	ADP
admet-831	33	9	aggregation	aggregation	NOUN
admet-831	33	10	and	and	CCONJ
admet-831	33	11	prion	prion	NOUN
admet-831	33	12	formation	formation	NOUN
admet-831	33	13	.	.	PUNCT
admet-831	34	1	these	these	DET
admet-831	34	2	secondary	secondary	ADJ
admet-831	34	3	structural	structural	ADJ
admet-831	34	4	elements	element	NOUN
admet-831	34	5	can	can	AUX
admet-831	34	6	stack	stack	VERB
admet-831	34	7	intraand	intraand	NOUN
admet-831	34	8	intermolecularly	intermolecularly	ADV
admet-831	34	9	to	to	PART
admet-831	34	10	form	form	VERB
admet-831	34	11	large	large	ADJ
admet-831	34	12	insoluble	insoluble	ADJ
admet-831	34	13	aggregates	aggregate	NOUN
admet-831	34	14	.	.	PUNCT
admet-831	35	1	even	even	ADV
admet-831	35	2	protein	protein	NOUN
admet-831	35	3	crystallization	crystallization	NOUN
admet-831	35	4	is	be	AUX
admet-831	35	5	related	relate	VERB
admet-831	35	6	to	to	ADP
admet-831	35	7	solubility	solubility	NOUN
admet-831	35	8	.	.	PUNCT
admet-831	36	1	ordered	order	VERB
admet-831	36	2	protein	protein	NOUN
admet-831	36	3	crystals	crystal	NOUN
admet-831	36	4	are	be	AUX
admet-831	36	5	needed	need	VERB
admet-831	36	6	for	for	ADP
admet-831	36	7	x	x	NOUN
admet-831	36	8	-	-	NOUN
admet-831	36	9	ray	ray	NOUN
admet-831	36	10	crystallography	crystallography	NOUN
admet-831	36	11	to	to	PART
admet-831	36	12	reveal	reveal	VERB
admet-831	36	13	protein	protein	NOUN
admet-831	36	14	structures	structure	NOUN
admet-831	36	15	.	.	PUNCT
admet-831	37	1	these	these	DET
admet-831	37	2	crystals	crystal	NOUN
admet-831	37	3	are	be	AUX
admet-831	37	4	grown	grow	VERB
admet-831	37	5	slowly	slowly	ADV
admet-831	37	6	and	and	CCONJ
admet-831	37	7	contain	contain	VERB
admet-831	37	8	typically	typically	ADV
admet-831	37	9	large	large	ADJ
admet-831	37	10	amounts	amount	NOUN
admet-831	37	11	of	of	ADP
admet-831	37	12	solvent	solvent	NOUN
admet-831	37	13	.	.	PUNCT
admet-831	38	1	the	the	DET
admet-831	38	2	goal	goal	NOUN
admet-831	38	3	of	of	ADP
admet-831	38	4	the	the	DET
admet-831	38	5	crystallization	crystallization	NOUN
admet-831	38	6	is	be	AUX
admet-831	38	7	to	to	PART
admet-831	38	8	keep	keep	VERB
admet-831	38	9	the	the	DET
admet-831	38	10	proteins	protein	NOUN
admet-831	38	11	in	in	ADP
admet-831	38	12	their	their	PRON
admet-831	38	13	native	native	ADJ
admet-831	38	14	conformation	conformation	NOUN
admet-831	38	15	,	,	PUNCT
admet-831	38	16	however	however	ADV
admet-831	38	17	certain	certain	ADJ
admet-831	38	18	packing	packing	NOUN
admet-831	38	19	effects	effect	NOUN
admet-831	38	20	affecting	affect	VERB
admet-831	38	21	local	local	ADJ
admet-831	38	22	conformation	conformation	NOUN
admet-831	38	23	are	be	AUX
admet-831	38	24	common	common	ADJ
admet-831	38	25	.	.	PUNCT
admet-831	39	1	figure	figure	NOUN
admet-831	39	2	1	1	NUM
admet-831	39	3	.	.	PUNCT
admet-831	40	1	relationships	relationship	NOUN
admet-831	40	2	of	of	ADP
admet-831	40	3	protein	protein	NOUN
admet-831	40	4	solubility	solubility	NOUN
admet-831	40	5	,	,	PUNCT
admet-831	40	6	aggregation	aggregation	NOUN
admet-831	40	7	and	and	CCONJ
admet-831	40	8	degradation	degradation	NOUN
admet-831	40	9	.	.	PUNCT
admet-831	41	1	insoluble	insoluble	ADJ
admet-831	41	2	protein	protein	NOUN
admet-831	41	3	is	be	AUX
admet-831	41	4	correctly	correctly	ADV
admet-831	41	5	folded	fold	VERB
admet-831	41	6	,	,	PUNCT
admet-831	41	7	whereas	whereas	SCONJ
admet-831	41	8	the	the	DET
admet-831	41	9	structure	structure	NOUN
admet-831	41	10	of	of	ADP
admet-831	41	11	aggregated	aggregate	VERB
admet-831	41	12	protein	protein	NOUN
admet-831	41	13	is	be	AUX
admet-831	41	14	altered	alter	VERB
admet-831	41	15	.	.	PUNCT
admet-831	42	1	most	most	ADV
admet-831	42	2	irreversibly	irreversibly	ADV
admet-831	42	3	misfolded	misfolde	VERB
admet-831	42	4	proteins	protein	NOUN
admet-831	42	5	are	be	AUX
admet-831	42	6	degraded	degrade	VERB
admet-831	42	7	as	as	ADP
admet-831	42	8	part	part	NOUN
admet-831	42	9	of	of	ADP
admet-831	42	10	normal	normal	ADJ
admet-831	42	11	protein	protein	NOUN
admet-831	42	12	turnover	turnover	NOUN
admet-831	42	13	.	.	PUNCT
admet-831	43	1	intrinsically	intrinsically	ADV
admet-831	43	2	disordered	disorder	VERB
admet-831	43	3	proteins	protein	NOUN
admet-831	43	4	and	and	CCONJ
admet-831	43	5	native	native	ADJ
admet-831	43	6	-	-	PUNCT
admet-831	43	7	like	like	ADJ
admet-831	43	8	structures	structure	NOUN
admet-831	43	9	have	have	VERB
admet-831	43	10	their	their	PRON
admet-831	43	11	specific	specific	ADJ
admet-831	43	12	aggregation	aggregation	NOUN
admet-831	43	13	mechanisms	mechanism	NOUN
admet-831	43	14	.	.	PUNCT
admet-831	44	1	many	many	ADJ
admet-831	44	2	factors	factor	NOUN
admet-831	44	3	affect	affect	VERB
admet-831	44	4	solubility	solubility	NOUN
admet-831	44	5	and	and	CCONJ
admet-831	44	6	aggregation	aggregation	NOUN
admet-831	44	7	,	,	PUNCT
admet-831	44	8	including	include	VERB
admet-831	44	9	intrinsic	intrinsic	ADJ
admet-831	44	10	properties	property	NOUN
admet-831	44	11	of	of	ADP
admet-831	44	12	the	the	DET
admet-831	44	13	protein	protein	NOUN
admet-831	44	14	,	,	PUNCT
admet-831	44	15	solvent	solvent	NOUN
admet-831	44	16	and	and	CCONJ
admet-831	44	17	additives	additive	NOUN
admet-831	44	18	as	as	ADV
admet-831	44	19	well	well	ADV
admet-831	44	20	as	as	ADP
admet-831	44	21	physical	physical	ADJ
admet-831	44	22	conditions	condition	NOUN
admet-831	44	23	.	.	PUNCT
admet-831	45	1	list	list	NOUN
admet-831	45	2	of	of	ADP
admet-831	45	3	relevant	relevant	ADJ
admet-831	45	4	protein	protein	NOUN
admet-831	45	5	factors	factor	NOUN
admet-831	45	6	is	be	AUX
admet-831	45	7	long	long	ADJ
admet-831	45	8	and	and	CCONJ
admet-831	45	9	could	could	AUX
admet-831	45	10	be	be	AUX
admet-831	45	11	started	start	VERB
admet-831	45	12	with	with	ADP
admet-831	45	13	amino	amino	NOUN
admet-831	45	14	acid	acid	NOUN
admet-831	45	15	sequence	sequence	NOUN
admet-831	45	16	and	and	CCONJ
admet-831	45	17	composition	composition	NOUN
admet-831	45	18	,	,	PUNCT
admet-831	45	19	three	three	NUM
admet-831	45	20	-	-	PUNCT
admet-831	45	21	dimensional	dimensional	ADJ
admet-831	45	22	structure	structure	NOUN
admet-831	45	23	and	and	CCONJ
admet-831	45	24	exposure	exposure	NOUN
admet-831	45	25	of	of	ADP
admet-831	45	26	residues	residue	NOUN
admet-831	45	27	,	,	PUNCT
admet-831	45	28	intramolecular	intramolecular	ADJ
admet-831	45	29	interactions	interaction	NOUN
admet-831	45	30	within	within	ADP
admet-831	45	31	the	the	DET
admet-831	45	32	protein	protein	NOUN
admet-831	45	33	(	(	PUNCT
admet-831	45	34	salt	salt	NOUN
admet-831	45	35	bridges	bridge	NOUN
admet-831	45	36	,	,	PUNCT
admet-831	45	37	hydrogen	hydrogen	NOUN
admet-831	45	38	bonds	bond	NOUN
admet-831	45	39	,	,	PUNCT
admet-831	45	40	electrostatic	electrostatic	ADJ
admet-831	45	41	and	and	CCONJ
admet-831	45	42	hydrophobic	hydrophobic	NOUN
admet-831	45	43	interactions	interaction	NOUN
admet-831	45	44	,	,	PUNCT
admet-831	45	45	multimeric	multimeric	ADJ
admet-831	45	46	status	status	NOUN
admet-831	45	47	etc	etc	X
admet-831	45	48	.	.	X
admet-831	45	49	)	)	PUNCT
admet-831	45	50	,	,	PUNCT
admet-831	45	51	and	and	CCONJ
admet-831	45	52	protonation	protonation	NOUN
admet-831	45	53	status	status	NOUN
admet-831	45	54	.	.	PUNCT
admet-831	46	1	solvent	solvent	ADJ
admet-831	46	2	properties	property	NOUN
admet-831	46	3	(	(	PUNCT
admet-831	46	4	polarity	polarity	NOUN
admet-831	46	5	,	,	PUNCT
admet-831	46	6	bond	bond	NOUN
admet-831	46	7	and	and	CCONJ
admet-831	46	8	interaction	interaction	NOUN
admet-831	46	9	forming	form	VERB
admet-831	46	10	ability	ability	NOUN
admet-831	46	11	,	,	PUNCT
admet-831	46	12	density	density	NOUN
admet-831	46	13	etc	etc	X
admet-831	46	14	.	.	PUNCT
admet-831	46	15	)	)	PUNCT
admet-831	46	16	and	and	CCONJ
admet-831	46	17	constituents	constituent	NOUN
admet-831	46	18	(	(	PUNCT
admet-831	46	19	such	such	ADJ
admet-831	46	20	as	as	ADP
admet-831	46	21	excipients	excipient	NOUN
admet-831	46	22	,	,	PUNCT
admet-831	46	23	salts	salt	NOUN
admet-831	46	24	or	or	CCONJ
admet-831	46	25	organic	organic	ADJ
admet-831	46	26	solvents	solvent	NOUN
admet-831	46	27	)	)	PUNCT
admet-831	46	28	and	and	CCONJ
admet-831	46	29	their	their	PRON
admet-831	46	30	concentrations	concentration	NOUN
admet-831	46	31	have	have	VERB
admet-831	46	32	significant	significant	ADJ
admet-831	46	33	contributions	contribution	NOUN
admet-831	46	34	to	to	ADP
admet-831	46	35	solubility	solubility	NOUN
admet-831	46	36	.	.	PUNCT
admet-831	47	1	further	far	ADV
admet-831	47	2	,	,	PUNCT
admet-831	47	3	factors	factor	NOUN
admet-831	47	4	like	like	ADP
admet-831	47	5	ph	ph	NOUN
admet-831	47	6	and	and	CCONJ
admet-831	47	7	temperature	temperature	NOUN
admet-831	47	8	affect	affect	VERB
admet-831	47	9	both	both	CCONJ
admet-831	47	10	the	the	DET
admet-831	47	11	protein	protein	NOUN
admet-831	47	12	and	and	CCONJ
admet-831	47	13	solvent	solvent	NOUN
admet-831	47	14	.	.	PUNCT
admet-831	48	1	proteins	protein	NOUN
admet-831	48	2	are	be	AUX
admet-831	48	3	large	large	ADJ
admet-831	48	4	and	and	CCONJ
admet-831	48	5	relatively	relatively	ADV
admet-831	48	6	fragile	fragile	ADJ
admet-831	48	7	molecules	molecule	NOUN
admet-831	48	8	,	,	PUNCT
admet-831	48	9	thus	thus	ADV
admet-831	48	10	not	not	PART
admet-831	48	11	necessarily	necessarily	ADV
admet-831	48	12	ideal	ideal	ADJ
admet-831	48	13	as	as	ADP
admet-831	48	14	drugs	drug	NOUN
admet-831	48	15	.	.	PUNCT
admet-831	49	1	lots	lot	NOUN
admet-831	49	2	of	of	ADP
admet-831	49	3	research	research	NOUN
admet-831	49	4	has	have	AUX
admet-831	49	5	been	be	AUX
admet-831	49	6	devoted	devote	VERB
admet-831	49	7	to	to	PART
admet-831	49	8	find	find	VERB
admet-831	49	9	smaller	small	ADJ
admet-831	49	10	structures	structure	NOUN
admet-831	49	11	having	have	VERB
admet-831	49	12	(	(	PUNCT
admet-831	49	13	some	some	PRON
admet-831	49	14	)	)	PUNCT
admet-831	49	15	functions	function	NOUN
admet-831	49	16	of	of	ADP
admet-831	49	17	the	the	DET
admet-831	49	18	biological	biological	ADJ
admet-831	49	19	proteins	protein	NOUN
admet-831	49	20	.	.	PUNCT
admet-831	50	1	miniproteins	miniprotein	NOUN
admet-831	50	2	or	or	CCONJ
admet-831	50	3	protein	protein	NOUN
admet-831	50	4	scaffolds	scaffold	NOUN
admet-831	50	5	have	have	AUX
admet-831	50	6	been	be	AUX
admet-831	50	7	tested	test	VERB
admet-831	50	8	as	as	ADP
admet-831	50	9	biologics	biologic	NOUN
admet-831	50	10	[	[	X
admet-831	50	11	6	6	NUM
admet-831	50	12	]	]	PUNCT
admet-831	50	13	.	.	PUNCT
admet-831	51	1	some	some	DET
admet-831	51	2	functions	function	NOUN
admet-831	51	3	can	can	AUX
admet-831	51	4	be	be	AUX
admet-831	51	5	retained	retain	VERB
admet-831	51	6	even	even	ADV
admet-831	51	7	in	in	ADP
admet-831	51	8	short	short	ADJ
admet-831	51	9	peptides	peptide	NOUN
admet-831	51	10	as	as	SCONJ
admet-831	51	11	highlighted	highlight	VERB
admet-831	51	12	by	by	ADP
admet-831	51	13	2018	2018	NUM
admet-831	51	14	nobel	nobel	PROPN
admet-831	51	15	prize	prize	PROPN
admet-831	51	16	in	in	ADP
admet-831	51	17	chemistry	chemistry	NOUN
admet-831	51	18	for	for	ADP
admet-831	51	19	frances	frances	PROPN
admet-831	51	20	h.	h.	PROPN
admet-831	51	21	arnold	arnold	PROPN
admet-831	51	22	,	,	PUNCT
admet-831	51	23	george	george	PROPN
admet-831	51	24	p.	p.	PROPN
admet-831	51	25	smith	smith	PROPN
admet-831	51	26	and	and	CCONJ
admet-831	51	27	sir	sir	PROPN
admet-831	51	28	gregory	gregory	PROPN
admet-831	51	29	p.	p.	PROPN
admet-831	51	30	winter	winter	PROPN
admet-831	51	31	,	,	PUNCT
admet-831	51	32	the	the	DET
admet-831	51	33	last	last	ADJ
admet-831	51	34	two	two	NUM
admet-831	51	35	ones	one	NOUN
admet-831	51	36	"	"	PUNCT
admet-831	51	37	for	for	ADP
admet-831	51	38	the	the	DET
admet-831	51	39	phage	phage	NOUN
admet-831	51	40	display	display	NOUN
admet-831	51	41	of	of	ADP
admet-831	51	42	peptides	peptide	NOUN
admet-831	51	43	and	and	CCONJ
admet-831	51	44	antibodies	antibodie	VERB
admet-831	51	45	"	"	PUNCT
admet-831	51	46	by	by	ADP
admet-831	51	47	developing	develop	VERB
admet-831	51	48	small	small	ADJ
admet-831	51	49	binding	bind	VERB
admet-831	51	50	molecules	molecule	NOUN
admet-831	51	51	.	.	PUNCT
admet-831	52	1	in	in	ADP
admet-831	52	2	this	this	DET
admet-831	52	3	respect	respect	NOUN
admet-831	52	4	,	,	PUNCT
admet-831	52	5	cyclic	cyclic	ADJ
admet-831	52	6	peptides	peptide	NOUN
admet-831	52	7	are	be	AUX
admet-831	52	8	of	of	ADP
admet-831	52	9	interest	interest	NOUN
admet-831	52	10	as	as	SCONJ
admet-831	52	11	they	they	PRON
admet-831	52	12	have	have	VERB
admet-831	52	13	more	more	ADJ
admet-831	52	14	conformational	conformational	ADJ
admet-831	52	15	restraints	restraint	NOUN
admet-831	52	16	than	than	ADP
admet-831	52	17	linear	linear	ADJ
admet-831	52	18	molecules	molecule	NOUN
admet-831	52	19	.	.	PUNCT
admet-831	53	1	admet	admet	PROPN
admet-831	53	2	&	&	CCONJ
admet-831	53	3	dmpk	dmpk	PROPN
admet-831	53	4	8(4	8(4	NOUN
admet-831	53	5	)	)	PUNCT
admet-831	53	6	(	(	PUNCT
admet-831	53	7	2020	2020	NUM
admet-831	53	8	)	)	PUNCT
admet-831	53	9	391	391	NUM
admet-831	53	10	-	-	SYM
admet-831	53	11	399	399	NUM
admet-831	53	12	solubility	solubility	NOUN
admet-831	53	13	of	of	ADP
admet-831	53	14	proteins	protein	NOUN
admet-831	53	15	doi	doi	NOUN
admet-831	53	16	:	:	PUNCT
admet-831	53	17	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	NOUN
admet-831	53	18	393	393	NUM
admet-831	53	19	quite	quite	ADV
admet-831	53	20	successful	successful	ADJ
admet-831	53	21	solubility	solubility	NOUN
admet-831	53	22	prediction	prediction	NOUN
admet-831	53	23	methods	method	NOUN
admet-831	53	24	have	have	AUX
admet-831	53	25	been	be	AUX
admet-831	53	26	developed	develop	VERB
admet-831	53	27	for	for	ADP
admet-831	53	28	small	small	ADJ
admet-831	53	29	molecules	molecule	NOUN
admet-831	53	30	that	that	PRON
admet-831	53	31	are	be	AUX
admet-831	53	32	most	most	ADV
admet-831	53	33	common	common	ADJ
admet-831	53	34	as	as	ADP
admet-831	53	35	drugs	drug	NOUN
admet-831	53	36	(	(	PUNCT
admet-831	53	37	see	see	VERB
admet-831	53	38	chapters	chapter	NOUN
admet-831	53	39	in	in	ADP
admet-831	53	40	this	this	DET
admet-831	53	41	volume	volume	NOUN
admet-831	53	42	)	)	PUNCT
admet-831	53	43	.	.	PUNCT
admet-831	54	1	these	these	DET
admet-831	54	2	methods	method	NOUN
admet-831	54	3	,	,	PUNCT
admet-831	54	4	however	however	ADV
admet-831	54	5	,	,	PUNCT
admet-831	54	6	do	do	AUX
admet-831	54	7	not	not	PART
admet-831	54	8	work	work	VERB
admet-831	54	9	for	for	ADP
admet-831	54	10	proteins	protein	NOUN
admet-831	54	11	.	.	PUNCT
admet-831	55	1	there	there	PRON
admet-831	55	2	are	be	VERB
admet-831	55	3	several	several	ADJ
admet-831	55	4	reasons	reason	NOUN
admet-831	55	5	.	.	PUNCT
admet-831	56	1	proteins	protein	NOUN
admet-831	56	2	are	be	AUX
admet-831	56	3	much	much	ADV
admet-831	56	4	larger	large	ADJ
admet-831	56	5	,	,	PUNCT
admet-831	56	6	they	they	PRON
admet-831	56	7	have	have	VERB
admet-831	56	8	lots	lot	NOUN
admet-831	56	9	of	of	ADP
admet-831	56	10	groups	group	NOUN
admet-831	56	11	and	and	CCONJ
admet-831	56	12	protein	protein	NOUN
admet-831	56	13	folding	folding	NOUN
admet-831	56	14	affects	affect	VERB
admet-831	56	15	the	the	DET
admet-831	56	16	solvent	solvent	ADJ
admet-831	56	17	accessibility	accessibility	NOUN
admet-831	56	18	of	of	ADP
admet-831	56	19	the	the	DET
admet-831	56	20	groups	group	NOUN
admet-831	56	21	.	.	PUNCT
admet-831	57	1	further	far	ADV
admet-831	57	2	,	,	PUNCT
admet-831	57	3	the	the	DET
admet-831	57	4	protein	protein	NOUN
admet-831	57	5	structures	structure	NOUN
admet-831	57	6	are	be	AUX
admet-831	57	7	flexible	flexible	ADJ
admet-831	57	8	and	and	CCONJ
admet-831	57	9	have	have	VERB
admet-831	57	10	a	a	DET
admet-831	57	11	large	large	ADJ
admet-831	57	12	number	number	NOUN
admet-831	57	13	of	of	ADP
admet-831	57	14	slightly	slightly	ADV
admet-831	57	15	different	different	ADJ
admet-831	57	16	conformations	conformation	NOUN
admet-831	57	17	.	.	PUNCT
admet-831	58	1	therefore	therefore	ADV
admet-831	58	2	,	,	PUNCT
admet-831	58	3	different	different	ADJ
admet-831	58	4	approaches	approach	NOUN
admet-831	58	5	are	be	AUX
admet-831	58	6	needed	need	VERB
admet-831	58	7	for	for	ADP
admet-831	58	8	protein	protein	NOUN
admet-831	58	9	solubility	solubility	NOUN
admet-831	58	10	prediction	prediction	NOUN
admet-831	58	11	.	.	PUNCT
admet-831	59	1	here	here	ADV
admet-831	59	2	,	,	PUNCT
admet-831	59	3	methods	method	NOUN
admet-831	59	4	for	for	ADP
admet-831	59	5	protein	protein	NOUN
admet-831	59	6	solubility	solubility	NOUN
admet-831	59	7	and	and	CCONJ
admet-831	59	8	aggregation	aggregation	NOUN
admet-831	59	9	prediction	prediction	NOUN
admet-831	59	10	are	be	AUX
admet-831	59	11	introduced	introduce	VERB
admet-831	59	12	.	.	PUNCT
admet-831	60	1	further	far	ADV
admet-831	60	2	,	,	PUNCT
admet-831	60	3	methods	method	NOUN
admet-831	60	4	to	to	PART
admet-831	60	5	investigate	investigate	VERB
admet-831	60	6	the	the	DET
admet-831	60	7	effects	effect	NOUN
admet-831	60	8	on	on	ADP
admet-831	60	9	solubility	solubility	NOUN
admet-831	60	10	due	due	ADP
admet-831	60	11	to	to	ADP
admet-831	60	12	amino	amino	NOUN
admet-831	60	13	acid	acid	NOUN
admet-831	60	14	substitutions	substitution	NOUN
admet-831	60	15	(	(	PUNCT
admet-831	60	16	variations	variation	NOUN
admet-831	60	17	)	)	PUNCT
admet-831	60	18	are	be	AUX
admet-831	60	19	discussed	discuss	VERB
admet-831	60	20	.	.	PUNCT
admet-831	61	1	this	this	DET
admet-831	61	2	topic	topic	NOUN
admet-831	61	3	is	be	AUX
admet-831	61	4	important	important	ADJ
admet-831	61	5	for	for	ADP
admet-831	61	6	the	the	DET
admet-831	61	7	design	design	NOUN
admet-831	61	8	of	of	ADP
admet-831	61	9	changes	change	NOUN
admet-831	61	10	for	for	ADP
admet-831	61	11	protein	protein	NOUN
admet-831	61	12	engineering	engineering	NOUN
admet-831	61	13	e.g.	e.g.	ADV
admet-831	61	14	to	to	PART
admet-831	61	15	increase	increase	VERB
admet-831	61	16	protein	protein	NOUN
admet-831	61	17	solubility	solubility	NOUN
admet-831	61	18	,	,	PUNCT
admet-831	61	19	production	production	NOUN
admet-831	61	20	etc	etc	X
admet-831	61	21	.	.	X
admet-831	61	22	protein	protein	NOUN
admet-831	61	23	solubility	solubility	NOUN
admet-831	61	24	is	be	AUX
admet-831	61	25	discussed	discuss	VERB
admet-831	61	26	here	here	ADV
admet-831	61	27	from	from	ADP
admet-831	61	28	the	the	DET
admet-831	61	29	perspective	perspective	NOUN
admet-831	61	30	of	of	ADP
admet-831	61	31	predictions	prediction	NOUN
admet-831	61	32	for	for	ADP
admet-831	61	33	solubility	solubility	NOUN
admet-831	61	34	,	,	PUNCT
admet-831	61	35	aggregation	aggregation	NOUN
admet-831	61	36	and	and	CCONJ
admet-831	61	37	for	for	ADP
admet-831	61	38	variation	variation	NOUN
admet-831	61	39	effects	effect	NOUN
admet-831	61	40	.	.	PUNCT
admet-831	62	1	the	the	DET
admet-831	62	2	principles	principle	NOUN
admet-831	62	3	of	of	ADP
admet-831	62	4	the	the	DET
admet-831	62	5	methods	method	NOUN
admet-831	62	6	are	be	AUX
admet-831	62	7	discussed	discuss	VERB
admet-831	62	8	along	along	ADP
admet-831	62	9	with	with	ADP
admet-831	62	10	performances	performance	NOUN
admet-831	62	11	of	of	ADP
admet-831	62	12	the	the	DET
admet-831	62	13	tools	tool	NOUN
admet-831	62	14	.	.	PUNCT
admet-831	63	1	it	it	PRON
admet-831	63	2	is	be	AUX
admet-831	63	3	apparent	apparent	ADJ
admet-831	63	4	that	that	SCONJ
admet-831	63	5	the	the	DET
admet-831	63	6	performances	performance	NOUN
admet-831	63	7	of	of	ADP
admet-831	63	8	the	the	DET
admet-831	63	9	methods	method	NOUN
admet-831	63	10	are	be	AUX
admet-831	63	11	not	not	PART
admet-831	63	12	very	very	ADV
admet-831	63	13	high	high	ADJ
admet-831	63	14	,	,	PUNCT
admet-831	63	15	which	which	PRON
admet-831	63	16	is	be	AUX
admet-831	63	17	due	due	ADJ
admet-831	63	18	to	to	ADP
admet-831	63	19	the	the	DET
admet-831	63	20	complexity	complexity	NOUN
admet-831	63	21	of	of	ADP
admet-831	63	22	the	the	DET
admet-831	63	23	phenomenon	phenomenon	NOUN
admet-831	63	24	and	and	CCONJ
admet-831	63	25	thereby	thereby	ADV
admet-831	63	26	difficulty	difficulty	NOUN
admet-831	63	27	in	in	ADP
admet-831	63	28	finding	find	VERB
admet-831	63	29	good	good	ADJ
admet-831	63	30	features	feature	NOUN
admet-831	63	31	that	that	PRON
admet-831	63	32	would	would	AUX
admet-831	63	33	reliably	reliably	ADV
admet-831	63	34	distinguish	distinguish	VERB
admet-831	63	35	between	between	ADP
admet-831	63	36	the	the	DET
admet-831	63	37	solubility	solubility	NOUN
admet-831	63	38	states	state	NOUN
admet-831	63	39	.	.	PUNCT
admet-831	64	1	one	one	NUM
admet-831	64	2	limiting	limit	VERB
admet-831	64	3	factor	factor	NOUN
admet-831	64	4	has	have	AUX
admet-831	64	5	been	be	AUX
admet-831	64	6	the	the	DET
admet-831	64	7	small	small	ADJ
admet-831	64	8	number	number	NOUN
admet-831	64	9	of	of	ADP
admet-831	64	10	experimentally	experimentally	ADV
admet-831	64	11	verified	verify	VERB
admet-831	64	12	cases	case	NOUN
admet-831	64	13	.	.	PUNCT
admet-831	65	1	however	however	ADV
admet-831	65	2	,	,	PUNCT
admet-831	65	3	the	the	DET
admet-831	65	4	field	field	NOUN
admet-831	65	5	is	be	AUX
admet-831	65	6	making	make	VERB
admet-831	65	7	progress	progress	NOUN
admet-831	65	8	and	and	CCONJ
admet-831	65	9	there	there	PRON
admet-831	65	10	are	be	VERB
admet-831	65	11	some	some	DET
admet-831	65	12	rather	rather	ADV
admet-831	65	13	good	good	ADJ
admet-831	65	14	methods	method	NOUN
admet-831	65	15	available	available	ADJ
admet-831	65	16	.	.	PUNCT
admet-831	66	1	solubility	solubility	NOUN
admet-831	66	2	prediction	prediction	NOUN
admet-831	66	3	during	during	ADP
admet-831	66	4	the	the	DET
admet-831	66	5	last	last	ADJ
admet-831	66	6	decade	decade	NOUN
admet-831	66	7	,	,	PUNCT
admet-831	66	8	several	several	ADJ
admet-831	66	9	computational	computational	ADJ
admet-831	66	10	methods	method	NOUN
admet-831	66	11	have	have	AUX
admet-831	66	12	been	be	AUX
admet-831	66	13	developed	develop	VERB
admet-831	66	14	to	to	PART
admet-831	66	15	predict	predict	VERB
admet-831	66	16	protein	protein	NOUN
admet-831	66	17	solubility	solubility	NOUN
admet-831	66	18	,	,	PUNCT
admet-831	66	19	especially	especially	ADV
admet-831	66	20	in	in	ADP
admet-831	66	21	the	the	DET
admet-831	66	22	context	context	NOUN
admet-831	66	23	of	of	ADP
admet-831	66	24	heterologous	heterologous	ADJ
admet-831	66	25	protein	protein	NOUN
admet-831	66	26	overexpression	overexpression	NOUN
admet-831	66	27	.	.	PUNCT
admet-831	67	1	these	these	DET
admet-831	67	2	methods	method	NOUN
admet-831	67	3	utilize	utilize	VERB
admet-831	67	4	different	different	ADJ
admet-831	67	5	approaches	approach	NOUN
admet-831	67	6	,	,	PUNCT
admet-831	67	7	often	often	ADV
admet-831	67	8	in	in	ADP
admet-831	67	9	the	the	DET
admet-831	67	10	field	field	NOUN
admet-831	67	11	of	of	ADP
admet-831	67	12	machine	machine	NOUN
admet-831	67	13	learning	learning	NOUN
admet-831	67	14	.	.	PUNCT
admet-831	68	1	solubility	solubility	NOUN
admet-831	68	2	is	be	AUX
admet-831	68	3	a	a	DET
admet-831	68	4	complex	complex	ADJ
admet-831	68	5	phenomenon	phenomenon	NOUN
admet-831	68	6	and	and	CCONJ
admet-831	68	7	good	good	ADJ
admet-831	68	8	predictive	predictive	ADJ
admet-831	68	9	features	feature	NOUN
admet-831	68	10	are	be	AUX
admet-831	68	11	difficult	difficult	ADJ
admet-831	68	12	to	to	PART
admet-831	68	13	find	find	VERB
admet-831	68	14	,	,	PUNCT
admet-831	68	15	however	however	ADV
admet-831	68	16	,	,	PUNCT
admet-831	68	17	there	there	PRON
admet-831	68	18	are	be	VERB
admet-831	68	19	some	some	DET
admet-831	68	20	trends	trend	NOUN
admet-831	68	21	such	such	ADJ
admet-831	68	22	as	as	ADP
admet-831	68	23	residue	residue	NOUN
admet-831	68	24	-	-	PUNCT
admet-831	68	25	residue	residue	NOUN
admet-831	68	26	interactions	interaction	NOUN
admet-831	68	27	[	[	X
admet-831	68	28	7	7	NUM
admet-831	68	29	]	]	PUNCT
admet-831	68	30	and	and	CCONJ
admet-831	68	31	structural	structural	ADJ
admet-831	68	32	flexibility	flexibility	NOUN
admet-831	68	33	[	[	X
admet-831	68	34	8	8	NUM
admet-831	68	35	]	]	PUNCT
admet-831	68	36	.	.	PUNCT
admet-831	69	1	based	base	VERB
admet-831	69	2	on	on	ADP
admet-831	69	3	examples	example	NOUN
admet-831	69	4	with	with	ADP
admet-831	69	5	known	know	VERB
admet-831	69	6	solubility	solubility	NOUN
admet-831	69	7	,	,	PUNCT
admet-831	69	8	computer	computer	NOUN
admet-831	69	9	tools	tool	NOUN
admet-831	69	10	have	have	AUX
admet-831	69	11	been	be	AUX
admet-831	69	12	trained	train	VERB
admet-831	69	13	(	(	PUNCT
admet-831	69	14	see	see	VERB
admet-831	70	1	e.g.	e.g.	ADV
admet-831	70	2	[	[	X
admet-831	70	3	9	9	NUM
admet-831	70	4	]	]	SYM
admet-831	70	5	)	)	PUNCT
admet-831	70	6	.	.	PUNCT
admet-831	71	1	protein	protein	NOUN
admet-831	71	2	related	relate	VERB
admet-831	71	3	parameters	parameter	NOUN
admet-831	71	4	such	such	ADJ
admet-831	71	5	as	as	ADP
admet-831	71	6	hydropathy	hydropathy	ADJ
admet-831	71	7	scales	scale	NOUN
admet-831	71	8	and	and	CCONJ
admet-831	71	9	amino	amino	NOUN
admet-831	71	10	acid	acid	NOUN
admet-831	71	11	compositions	composition	NOUN
admet-831	71	12	have	have	AUX
admet-831	71	13	been	be	AUX
admet-831	71	14	used	use	VERB
admet-831	71	15	as	as	ADP
admet-831	71	16	features	feature	NOUN
admet-831	71	17	.	.	PUNCT
admet-831	72	1	the	the	DET
admet-831	72	2	best	good	ADJ
admet-831	72	3	methods	method	NOUN
admet-831	72	4	claim	claim	VERB
admet-831	72	5	accuracy	accuracy	NOUN
admet-831	72	6	of	of	ADP
admet-831	72	7	over	over	ADP
admet-831	72	8	80	80	NUM
admet-831	72	9	%	%	NOUN
admet-831	72	10	for	for	ADP
admet-831	72	11	two	two	NUM
admet-831	72	12	-	-	PUNCT
admet-831	72	13	state	state	NOUN
admet-831	72	14	predictions	prediction	NOUN
admet-831	72	15	of	of	ADP
admet-831	72	16	soluble	soluble	ADJ
admet-831	72	17	/	/	SYM
admet-831	72	18	insoluble	insoluble	ADJ
admet-831	72	19	.	.	PUNCT
admet-831	73	1	methods	method	NOUN
admet-831	73	2	in	in	ADP
admet-831	73	3	this	this	DET
admet-831	73	4	category	category	NOUN
admet-831	73	5	include	include	VERB
admet-831	73	6	ccsol	ccsol	NOUN
admet-831	73	7	omics	omic	NOUN
admet-831	74	1	[	[	X
admet-831	74	2	10	10	NUM
admet-831	74	3	]	]	PUNCT
admet-831	74	4	,	,	PUNCT
admet-831	74	5	deepsol	deepsol	ADJ
admet-831	74	6	[	[	X
admet-831	74	7	11	11	NUM
admet-831	74	8	]	]	PUNCT
admet-831	74	9	,	,	PUNCT
admet-831	74	10	parsnip	parsnip	NOUN
admet-831	75	1	[	[	X
admet-831	75	2	12	12	NUM
admet-831	75	3	]	]	PUNCT
admet-831	75	4	,	,	PUNCT
admet-831	75	5	protein	protein	NOUN
admet-831	75	6	-	-	PUNCT
admet-831	75	7	sol	sol	NOUN
admet-831	76	1	[	[	X
admet-831	76	2	13	13	NUM
admet-831	76	3	]	]	PUNCT
admet-831	76	4	,	,	PUNCT
admet-831	76	5	soda	soda	NOUN
admet-831	76	6	[	[	X
admet-831	76	7	14	14	NUM
admet-831	76	8	]	]	PUNCT
admet-831	76	9	,	,	PUNCT
admet-831	76	10	solart	solart	NOUN
admet-831	76	11	[	[	X
admet-831	76	12	15	15	NUM
admet-831	76	13	]	]	X
admet-831	76	14	,	,	PUNCT
admet-831	76	15	solpro	solpro	ADJ
admet-831	76	16	[	[	X
admet-831	76	17	16	16	NUM
admet-831	76	18	]	]	PUNCT
admet-831	76	19	,	,	PUNCT
admet-831	76	20	swi	swi	PROPN
admet-831	77	1	[	[	X
admet-831	77	2	8	8	NUM
admet-831	77	3	]	]	PUNCT
admet-831	77	4	and	and	CCONJ
admet-831	77	5	others	other	NOUN
admet-831	77	6	.	.	PUNCT
admet-831	78	1	table	table	NOUN
admet-831	78	2	1	1	NUM
admet-831	78	3	.	.	PUNCT
admet-831	78	4	protein	protein	NOUN
admet-831	78	5	solubility	solubility	NOUN
admet-831	78	6	predictors	predictor	NOUN
admet-831	78	7	method	method	VERB
admet-831	78	8	url	url	NOUN
admet-831	78	9	trained	train	VERB
admet-831	78	10	with	with	ADP
admet-831	78	11	data	datum	NOUN
admet-831	78	12	from	from	ADP
admet-831	78	13	structural	structural	ADJ
admet-831	78	14	biology	biology	NOUN
admet-831	78	15	knowledgebase	knowledgebase	PROPN
admet-831	78	16	ccsol	ccsol	PROPN
admet-831	78	17	omics	omics	PROPN
admet-831	78	18	http://s.tartaglialab.com/update_submission/45568/57e42bea38	http://s.tartaglialab.com/update_submission/45568/57e42bea38	PROPN
admet-831	78	19	deepsol	deepsol	ADJ
admet-831	78	20	https://zenodo.org/record/1162886#.xoxw_egxvey	https://zenodo.org/record/1162886#.xoxw_egxvey	NOUN
admet-831	78	21	parsnip	parsnip	PROPN
admet-831	78	22	https://github.com/redarawi/parsnip	https://github.com/redarawi/parsnip	PROPN
admet-831	79	1	swi	swi	PROPN
admet-831	79	2	https://tisigner.com/sodope	https://tisigner.com/sodope	PROPN
admet-831	79	3	trained	train	VERB
admet-831	79	4	with	with	ADP
admet-831	79	5	data	datum	NOUN
admet-831	79	6	from	from	ADP
admet-831	79	7	esol	esol	PROPN
admet-831	79	8	proteinsol	proteinsol	PROPN
admet-831	79	9	https://protein-sol.manchester.ac.uk/	https://protein-sol.manchester.ac.uk/	PROPN
admet-831	79	10	solart	solart	PROPN
admet-831	79	11	http://babylone.ulb.ac.be/solart/	http://babylone.ulb.ac.be/solart/	PROPN
admet-831	79	12	solpro	solpro	ADJ
admet-831	79	13	http://scratch.proteomics.ics.uci.edu/	http://scratch.proteomics.ics.uci.edu/	PROPN
admet-831	79	14	trained	train	VERB
admet-831	79	15	with	with	ADP
admet-831	79	16	data	datum	NOUN
admet-831	79	17	from	from	ADP
admet-831	79	18	pon	pon	ADJ
admet-831	79	19	-	-	PUNCT
admet-831	79	20	sol	sol	NOUN
admet-831	79	21	soda	soda	NOUN
admet-831	79	22	http://old.protein.bio.unipd.it/soda/	http://old.protein.bio.unipd.it/soda/	NOUN
admet-831	79	23	most	most	ADJ
admet-831	79	24	methods	method	NOUN
admet-831	79	25	are	be	AUX
admet-831	79	26	trained	train	VERB
admet-831	79	27	on	on	ADP
admet-831	79	28	one	one	NUM
admet-831	79	29	of	of	ADP
admet-831	79	30	two	two	NUM
admet-831	79	31	major	major	ADJ
admet-831	79	32	datasets	dataset	NOUN
admet-831	79	33	.	.	PUNCT
admet-831	80	1	protein	protein	NOUN
admet-831	80	2	structure	structure	NOUN
admet-831	80	3	initiative	initiative	NOUN
admet-831	80	4	was	be	AUX
admet-831	80	5	a	a	DET
admet-831	80	6	large	large	ADJ
admet-831	80	7	project	project	NOUN
admet-831	80	8	to	to	PART
admet-831	80	9	determine	determine	VERB
admet-831	80	10	protein	protein	NOUN
admet-831	80	11	structures	structure	NOUN
admet-831	80	12	en	en	X
admet-831	80	13	masse	masse	NOUN
admet-831	80	14	.	.	PUNCT
admet-831	81	1	their	their	PRON
admet-831	81	2	structural	structural	ADJ
admet-831	81	3	biology	biology	NOUN
admet-831	81	4	knowledgebase	knowledgebase	NOUN
admet-831	81	5	[	[	X
admet-831	81	6	17	17	NUM
admet-831	81	7	]	]	PUNCT
admet-831	81	8	contains	contain	VERB
admet-831	81	9	information	information	NOUN
admet-831	81	10	for	for	ADP
admet-831	81	11	crystallization	crystallization	NOUN
admet-831	81	12	trials	trial	NOUN
admet-831	81	13	and	and	CCONJ
admet-831	81	14	for	for	ADP
admet-831	81	15	(	(	PUNCT
admet-831	81	16	heterologous	heterologous	ADJ
admet-831	81	17	)	)	PUNCT
admet-831	81	18	protein	protein	NOUN
admet-831	81	19	production	production	NOUN
admet-831	81	20	and	and	CCONJ
admet-831	81	21	has	have	AUX
admet-831	81	22	been	be	AUX
admet-831	81	23	used	use	VERB
admet-831	81	24	for	for	ADP
admet-831	81	25	training	train	VERB
admet-831	81	26	many	many	ADJ
admet-831	81	27	of	of	ADP
admet-831	81	28	the	the	DET
admet-831	81	29	tools	tool	NOUN
admet-831	81	30	including	include	VERB
admet-831	81	31	ccsol	ccsol	NOUN
admet-831	81	32	omics	omic	NOUN
admet-831	81	33	,	,	PUNCT
admet-831	81	34	parsnip	parsnip	NOUN
admet-831	81	35	,	,	PUNCT
admet-831	81	36	different	different	ADJ
admet-831	81	37	versions	version	NOUN
admet-831	81	38	of	of	ADP
admet-831	81	39	deepsol	deepsol	ADJ
admet-831	81	40	and	and	CCONJ
admet-831	81	41	swi	swi	PROPN
admet-831	81	42	.	.	PROPN
admet-831	81	43	esol	esol	PROPN
admet-831	81	44	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PROPN
admet-831	81	45	http://s.tartaglialab.com/update_submission/45568/57e42bea38	http://s.tartaglialab.com/update_submission/45568/57e42bea38	PROPN
admet-831	81	46	https://zenodo.org/record/1162886#.xoxw_egxvey	https://zenodo.org/record/1162886#.xoxw_egxvey	NOUN
admet-831	81	47	https://github.com/redarawi/parsnip	https://github.com/redarawi/parsnip	NOUN
admet-831	81	48	https://tisigner.com/sodope	https://tisigner.com/sodope	PROPN
admet-831	81	49	https://protein-sol.manchester.ac.uk/	https://protein-sol.manchester.ac.uk/	PROPN
admet-831	81	50	http://babylone.ulb.ac.be/solart/	http://babylone.ulb.ac.be/solart/	PROPN
admet-831	81	51	http://scratch.proteomics.ics.uci.edu/	http://scratch.proteomics.ics.uci.edu/	PROPN
admet-831	81	52	http://old.protein.bio.unipd.it/soda/	http://old.protein.bio.unipd.it/soda/	PUNCT
admet-831	81	53	mauno	mauno	PROPN
admet-831	81	54	vihinen	vihinen	PROPN
admet-831	81	55	admet	admet	PROPN
admet-831	81	56	&	&	CCONJ
admet-831	81	57	dmpk	dmpk	PROPN
admet-831	81	58	8(4	8(4	NOUN
admet-831	81	59	)	)	PUNCT
admet-831	81	60	(	(	PUNCT
admet-831	81	61	2020	2020	NUM
admet-831	81	62	)	)	PUNCT
admet-831	81	63	391	391	NUM
admet-831	81	64	-	-	SYM
admet-831	81	65	399	399	NUM
admet-831	81	66	394	394	NUM
admet-831	81	67	solubility	solubility	NOUN
admet-831	81	68	database	database	NOUN
admet-831	81	69	(	(	PUNCT
admet-831	81	70	http://tanpaku.org/tp-esol/index.php?lang=en	http://tanpaku.org/tp-esol/index.php?lang=en	PROPN
admet-831	81	71	)	)	PUNCT
admet-831	81	72	for	for	ADP
admet-831	81	73	almost	almost	ADV
admet-831	81	74	all	all	PRON
admet-831	81	75	esherichia	esherichia	ADJ
admet-831	81	76	coli	coli	NOUN
admet-831	81	77	proteins	protein	NOUN
admet-831	81	78	[	[	X
admet-831	81	79	18	18	NUM
admet-831	81	80	]	]	PUNCT
admet-831	81	81	has	have	AUX
admet-831	81	82	been	be	AUX
admet-831	81	83	used	use	VERB
admet-831	81	84	for	for	ADP
admet-831	81	85	some	some	DET
admet-831	81	86	other	other	ADJ
admet-831	81	87	methods	method	NOUN
admet-831	81	88	,	,	PUNCT
admet-831	81	89	such	such	ADJ
admet-831	81	90	as	as	ADP
admet-831	81	91	protein	protein	NOUN
admet-831	81	92	-	-	PUNCT
admet-831	81	93	sol	sol	NOUN
admet-831	81	94	,	,	PUNCT
admet-831	81	95	solart	solart	NOUN
admet-831	81	96	along	along	ADP
admet-831	81	97	with	with	ADP
admet-831	81	98	saccharomyces	saccharomyce	NOUN
admet-831	81	99	cerevisiae	cerevisiae	NOUN
admet-831	81	100	protein	protein	NOUN
admet-831	81	101	solubility	solubility	NOUN
admet-831	81	102	details	detail	NOUN
admet-831	81	103	[	[	X
admet-831	81	104	19	19	NUM
admet-831	81	105	]	]	PUNCT
admet-831	81	106	.	.	PUNCT
admet-831	82	1	the	the	DET
admet-831	82	2	remaining	remain	VERB
admet-831	82	3	methods	method	NOUN
admet-831	82	4	are	be	AUX
admet-831	82	5	trained	train	VERB
admet-831	82	6	with	with	ADP
admet-831	82	7	pon	pon	ADJ
admet-831	82	8	-	-	PUNCT
admet-831	82	9	sol	sol	NOUN
admet-831	82	10	data	datum	NOUN
admet-831	82	11	[	[	X
admet-831	82	12	4	4	NUM
admet-831	82	13	]	]	PUNCT
admet-831	82	14	or	or	CCONJ
admet-831	82	15	not	not	PART
admet-831	82	16	trained	train	VERB
admet-831	82	17	at	at	ADV
admet-831	82	18	all	all	ADV
admet-831	82	19	.	.	PUNCT
admet-831	83	1	although	although	SCONJ
admet-831	83	2	many	many	ADJ
admet-831	83	3	proteins	protein	NOUN
admet-831	83	4	are	be	AUX
admet-831	83	5	poorly	poorly	ADV
admet-831	83	6	soluble	soluble	ADJ
admet-831	83	7	their	their	PRON
admet-831	83	8	solubility	solubility	NOUN
admet-831	83	9	is	be	AUX
admet-831	83	10	biologically	biologically	ADV
admet-831	83	11	sufficient	sufficient	ADJ
admet-831	83	12	as	as	SCONJ
admet-831	83	13	many	many	ADJ
admet-831	83	14	proteins	protein	NOUN
admet-831	83	15	have	have	VERB
admet-831	83	16	very	very	ADV
admet-831	83	17	low	low	ADJ
admet-831	83	18	abundance	abundance	NOUN
admet-831	83	19	in	in	ADP
admet-831	83	20	cells	cell	NOUN
admet-831	83	21	[	[	X
admet-831	83	22	1	1	NUM
admet-831	83	23	]	]	PUNCT
admet-831	83	24	.	.	PUNCT
admet-831	84	1	data	datum	NOUN
admet-831	84	2	extracted	extract	VERB
admet-831	84	3	by	by	ADP
admet-831	84	4	deepsol	deepsol	ADJ
admet-831	84	5	developers	developer	NOUN
admet-831	84	6	from	from	ADP
admet-831	84	7	structural	structural	ADJ
admet-831	84	8	biology	biology	NOUN
admet-831	84	9	knowledgebase	knowledgebase	NOUN
admet-831	84	10	indicated	indicate	VERB
admet-831	84	11	that	that	SCONJ
admet-831	84	12	45.2	45.2	NUM
admet-831	84	13	%	%	NOUN
admet-831	84	14	out	out	ADP
admet-831	84	15	of	of	ADP
admet-831	84	16	129.643	129.643	NUM
admet-831	84	17	tested	test	VERB
admet-831	84	18	inherent	inherent	ADJ
admet-831	84	19	and	and	CCONJ
admet-831	84	20	heterologously	heterologously	ADV
admet-831	84	21	expressed	express	VERB
admet-831	84	22	proteins	protein	NOUN
admet-831	84	23	in	in	ADP
admet-831	84	24	e.	e.	PROPN
admet-831	84	25	coli	coli	PROPN
admet-831	84	26	were	be	AUX
admet-831	84	27	soluble	soluble	ADJ
admet-831	84	28	[	[	X
admet-831	84	29	11	11	NUM
admet-831	84	30	]	]	PUNCT
admet-831	84	31	.	.	PUNCT
admet-831	85	1	deepsol	deepsol	PROPN
admet-831	85	2	is	be	AUX
admet-831	85	3	a	a	DET
admet-831	85	4	deep	deep	ADJ
admet-831	85	5	learning	learning	NOUN
admet-831	85	6	method	method	NOUN
admet-831	85	7	,	,	PUNCT
admet-831	85	8	ccsol	ccsol	PROPN
admet-831	85	9	omics	omics	PROPN
admet-831	85	10	is	be	AUX
admet-831	85	11	a	a	DET
admet-831	85	12	support	support	NOUN
admet-831	85	13	vector	vector	NOUN
admet-831	85	14	machine	machine	NOUN
admet-831	85	15	solution	solution	NOUN
admet-831	85	16	,	,	PUNCT
admet-831	85	17	parsnip	parsnip	NOUN
admet-831	85	18	utilizes	utilize	VERB
admet-831	85	19	gradient	gradient	ADJ
admet-831	85	20	boosting	boosting	NOUN
admet-831	85	21	,	,	PUNCT
admet-831	85	22	solart	solart	NOUN
admet-831	85	23	random	random	ADJ
admet-831	85	24	forest	forest	NOUN
admet-831	85	25	,	,	PUNCT
admet-831	85	26	swi	swi	NOUN
admet-831	85	27	and	and	CCONJ
admet-831	85	28	protein	protein	NOUN
admet-831	85	29	-	-	PUNCT
admet-831	85	30	sol	sol	NOUN
admet-831	85	31	are	be	AUX
admet-831	85	32	based	base	VERB
admet-831	85	33	on	on	ADP
admet-831	85	34	weighted	weight	VERB
admet-831	85	35	scores	score	NOUN
admet-831	85	36	.	.	PUNCT
admet-831	86	1	details	detail	NOUN
admet-831	86	2	for	for	ADP
admet-831	86	3	the	the	DET
admet-831	86	4	algorithm	algorithm	NOUN
admet-831	86	5	used	use	VERB
admet-831	86	6	in	in	ADP
admet-831	86	7	soda	soda	NOUN
admet-831	86	8	have	have	AUX
admet-831	86	9	not	not	PART
admet-831	86	10	been	be	AUX
admet-831	86	11	released	release	VERB
admet-831	86	12	.	.	PUNCT
admet-831	87	1	as	as	ADP
admet-831	87	2	with	with	ADP
admet-831	87	3	any	any	DET
admet-831	87	4	prediction	prediction	NOUN
admet-831	87	5	task	task	NOUN
admet-831	87	6	,	,	PUNCT
admet-831	87	7	the	the	DET
admet-831	87	8	choice	choice	NOUN
admet-831	87	9	of	of	ADP
admet-831	87	10	the	the	DET
admet-831	87	11	tool(s	tool(s	NOUN
admet-831	87	12	)	)	PUNCT
admet-831	87	13	is	be	AUX
admet-831	87	14	important	important	ADJ
admet-831	87	15	.	.	PUNCT
admet-831	88	1	the	the	DET
admet-831	88	2	best	good	ADJ
admet-831	88	3	comparisons	comparison	NOUN
admet-831	88	4	are	be	AUX
admet-831	88	5	independent	independent	ADJ
admet-831	88	6	benchmark	benchmark	ADJ
admet-831	88	7	studies	study	NOUN
admet-831	88	8	[	[	X
admet-831	88	9	20	20	NUM
admet-831	88	10	,	,	PUNCT
admet-831	88	11	21	21	NUM
admet-831	88	12	]	]	PUNCT
admet-831	88	13	,	,	PUNCT
admet-831	88	14	however	however	ADV
admet-831	88	15	such	such	ADJ
admet-831	88	16	studies	study	NOUN
admet-831	88	17	are	be	AUX
admet-831	88	18	not	not	PART
admet-831	88	19	available	available	ADJ
admet-831	88	20	for	for	ADP
admet-831	88	21	any	any	PRON
admet-831	88	22	of	of	ADP
admet-831	88	23	the	the	DET
admet-831	88	24	prediction	prediction	NOUN
admet-831	88	25	tasks	task	NOUN
admet-831	88	26	discussed	discuss	VERB
admet-831	88	27	in	in	ADP
admet-831	88	28	here	here	ADV
admet-831	88	29	.	.	PUNCT
admet-831	89	1	instead	instead	ADV
admet-831	89	2	,	,	PUNCT
admet-831	89	3	there	there	PRON
admet-831	89	4	are	be	VERB
admet-831	89	5	some	some	DET
admet-831	89	6	comparisons	comparison	NOUN
admet-831	89	7	of	of	ADP
admet-831	89	8	methods	method	NOUN
admet-831	89	9	along	along	ADP
admet-831	89	10	with	with	ADP
admet-831	89	11	predictor	predictor	NOUN
admet-831	89	12	description	description	NOUN
admet-831	89	13	,	,	PUNCT
admet-831	89	14	including	include	VERB
admet-831	89	15	comparisons	comparison	NOUN
admet-831	89	16	of	of	ADP
admet-831	89	17	four	four	NUM
admet-831	89	18	[	[	X
admet-831	89	19	14	14	NUM
admet-831	89	20	]	]	PUNCT
admet-831	89	21	,	,	PUNCT
admet-831	89	22	seven	seven	NUM
admet-831	90	1	[	[	X
admet-831	90	2	12	12	NUM
admet-831	90	3	]	]	PUNCT
admet-831	90	4	and	and	CCONJ
admet-831	90	5	eight	eight	NUM
admet-831	90	6	[	[	NOUN
admet-831	90	7	11	11	NUM
admet-831	90	8	]	]	PUNCT
admet-831	90	9	tools	tool	NOUN
admet-831	90	10	.	.	PUNCT
admet-831	91	1	the	the	DET
admet-831	91	2	first	first	ADJ
admet-831	91	3	of	of	ADP
admet-831	91	4	these	these	DET
admet-831	91	5	studies	study	NOUN
admet-831	91	6	indicated	indicate	VERB
admet-831	91	7	soda	soda	NOUN
admet-831	91	8	to	to	PART
admet-831	91	9	be	be	AUX
admet-831	91	10	the	the	DET
admet-831	91	11	best	good	ADJ
admet-831	91	12	,	,	PUNCT
admet-831	91	13	accuracy	accuracy	NOUN
admet-831	91	14	59.2	59.2	NUM
admet-831	91	15	,	,	PUNCT
admet-831	91	16	the	the	DET
admet-831	91	17	second	second	ADJ
admet-831	91	18	parsnip	parsnip	NOUN
admet-831	91	19	(	(	PUNCT
admet-831	91	20	accuracy	accuracy	NOUN
admet-831	91	21	74.11	74.11	NUM
admet-831	91	22	and	and	CCONJ
admet-831	91	23	matthews	matthews	PROPN
admet-831	91	24	correlation	correlation	NOUN
admet-831	91	25	coefficient	coefficient	NOUN
admet-831	91	26	(	(	PUNCT
admet-831	91	27	mcc	mcc	NOUN
admet-831	91	28	)	)	PUNCT
admet-831	91	29	0.48	0.48	NUM
admet-831	91	30	)	)	PUNCT
admet-831	91	31	and	and	CCONJ
admet-831	91	32	now	now	ADV
admet-831	91	33	defunct	defunct	ADJ
admet-831	91	34	proso	proso	NOUN
admet-831	91	35	ii	ii	PROPN
admet-831	91	36	(	(	PUNCT
admet-831	91	37	accuracy	accuracy	NOUN
admet-831	91	38	64.35	64.35	NUM
admet-831	91	39	,	,	PUNCT
admet-831	91	40	mcc	mcc	NOUN
admet-831	91	41	0.31	0.31	NUM
admet-831	91	42	)	)	PUNCT
admet-831	92	1	[	[	X
admet-831	92	2	22	22	NUM
admet-831	92	3	]	]	PUNCT
admet-831	92	4	,	,	PUNCT
admet-831	92	5	and	and	CCONJ
admet-831	92	6	in	in	ADP
admet-831	92	7	the	the	DET
admet-831	92	8	third	third	ADJ
admet-831	92	9	deepsol	deepsol	ADJ
admet-831	92	10	,	,	PUNCT
admet-831	92	11	parsnip	parsnip	NOUN
admet-831	92	12	and	and	CCONJ
admet-831	92	13	proso	proso	PROPN
admet-831	92	14	ii	ii	PROPN
admet-831	92	15	were	be	AUX
admet-831	92	16	the	the	DET
admet-831	92	17	best	good	ADJ
admet-831	92	18	ones	one	NOUN
admet-831	92	19	with	with	ADP
admet-831	92	20	accuracies	accuracy	NOUN
admet-831	92	21	and	and	CCONJ
admet-831	92	22	mcc	mcc	NOUN
admet-831	92	23	values	value	NOUN
admet-831	92	24	of	of	ADP
admet-831	92	25	0.77/0.55	0.77/0.55	NUM
admet-831	92	26	,	,	PUNCT
admet-831	92	27	0.74/0.48	0.74/0.48	NUM
admet-831	92	28	and	and	CCONJ
admet-831	92	29	0.64/0.34	0.64/0.34	NUM
admet-831	92	30	,	,	PUNCT
admet-831	92	31	respectively	respectively	ADV
admet-831	92	32	.	.	PUNCT
admet-831	93	1	analysis	analysis	NOUN
admet-831	93	2	of	of	ADP
admet-831	93	3	predictions	prediction	NOUN
admet-831	93	4	for	for	ADP
admet-831	93	5	57	57	NUM
admet-831	93	6	udp	udp	NOUN
admet-831	93	7	-	-	ADJ
admet-831	93	8	dependent	dependent	ADJ
admet-831	93	9	glycosyltransferases	glycosyltransferase	NOUN
admet-831	93	10	with	with	ADP
admet-831	93	11	11	11	NUM
admet-831	93	12	predictors	predictor	NOUN
admet-831	93	13	[	[	X
admet-831	93	14	23	23	NUM
admet-831	93	15	]	]	PUNCT
admet-831	93	16	is	be	AUX
admet-831	93	17	interesting	interesting	ADJ
admet-831	93	18	,	,	PUNCT
admet-831	93	19	however	however	ADV
admet-831	93	20	,	,	PUNCT
admet-831	93	21	may	may	AUX
admet-831	93	22	be	be	AUX
admet-831	93	23	biased	bias	VERB
admet-831	93	24	due	due	ADJ
admet-831	93	25	to	to	ADP
admet-831	93	26	containing	contain	VERB
admet-831	93	27	proteins	protein	NOUN
admet-831	93	28	just	just	ADV
admet-831	93	29	from	from	ADP
admet-831	93	30	a	a	DET
admet-831	93	31	single	single	ADJ
admet-831	93	32	family	family	NOUN
admet-831	93	33	.	.	PUNCT
admet-831	94	1	the	the	DET
admet-831	94	2	best	well	ADV
admet-831	94	3	performing	perform	VERB
admet-831	94	4	methods	method	NOUN
admet-831	94	5	in	in	ADP
admet-831	94	6	their	their	PRON
admet-831	94	7	analysis	analysis	NOUN
admet-831	94	8	were	be	AUX
admet-831	94	9	soluprot	soluprot	ADJ
admet-831	94	10	,	,	PUNCT
admet-831	94	11	deepsol	deepsol	ADJ
admet-831	94	12	versions	version	NOUN
admet-831	94	13	3	3	NUM
admet-831	94	14	,	,	PUNCT
admet-831	94	15	1	1	NUM
admet-831	94	16	and	and	CCONJ
admet-831	94	17	2	2	NUM
admet-831	94	18	,	,	PUNCT
admet-831	94	19	solpro	solpro	ADJ
admet-831	94	20	and	and	CCONJ
admet-831	94	21	parsnip	parsnip	NOUN
admet-831	94	22	.	.	PUNCT
admet-831	95	1	unfortunately	unfortunately	ADV
admet-831	95	2	,	,	PUNCT
admet-831	95	3	the	the	DET
admet-831	95	4	results	result	NOUN
admet-831	95	5	are	be	AUX
admet-831	95	6	provided	provide	VERB
admet-831	95	7	only	only	ADV
admet-831	95	8	in	in	ADP
admet-831	95	9	a	a	DET
admet-831	95	10	format	format	NOUN
admet-831	95	11	of	of	ADP
admet-831	95	12	a	a	DET
admet-831	95	13	figure	figure	NOUN
admet-831	95	14	,	,	PUNCT
admet-831	95	15	thus	thus	ADV
admet-831	95	16	no	no	DET
admet-831	95	17	numbers	number	NOUN
admet-831	95	18	are	be	AUX
admet-831	95	19	available	available	ADJ
admet-831	95	20	.	.	PUNCT
admet-831	96	1	aggregation	aggregation	NOUN
admet-831	96	2	prediction	prediction	NOUN
admet-831	96	3	aggregation	aggregation	NOUN
admet-831	96	4	is	be	AUX
admet-831	96	5	largely	largely	ADV
admet-831	96	6	mediated	mediate	VERB
admet-831	96	7	by	by	ADP
admet-831	96	8	short	short	ADJ
admet-831	96	9	sequence	sequence	NOUN
admet-831	96	10	stretches	stretch	NOUN
admet-831	96	11	of	of	ADP
admet-831	96	12	consecutive	consecutive	ADJ
admet-831	96	13	residues	residue	NOUN
admet-831	96	14	,	,	PUNCT
admet-831	96	15	these	these	DET
admet-831	96	16	regions	region	NOUN
admet-831	96	17	are	be	AUX
admet-831	96	18	typically	typically	ADV
admet-831	96	19	15	15	NUM
admet-831	96	20	residues	residue	NOUN
admet-831	96	21	or	or	CCONJ
admet-831	96	22	longer	long	ADV
admet-831	96	23	[	[	X
admet-831	96	24	24	24	NUM
admet-831	96	25	]	]	PUNCT
admet-831	96	26	.	.	PUNCT
admet-831	97	1	almost	almost	ADV
admet-831	97	2	all	all	PRON
admet-831	97	3	human	human	ADJ
admet-831	97	4	proteins	protein	NOUN
admet-831	97	5	can	can	AUX
admet-831	97	6	form	form	VERB
admet-831	97	7	self	self	NOUN
admet-831	97	8	-	-	PUNCT
admet-831	97	9	complementary	complementary	ADJ
admet-831	97	10	and	and	CCONJ
admet-831	97	11	thus	thus	ADV
admet-831	97	12	aggregation	aggregation	NOUN
admet-831	97	13	-	-	PUNCT
admet-831	97	14	prone	prone	ADJ
admet-831	97	15	segments	segment	NOUN
admet-831	97	16	[	[	X
admet-831	97	17	25	25	NUM
admet-831	97	18	]	]	PUNCT
admet-831	97	19	.	.	PUNCT
admet-831	98	1	however	however	ADV
admet-831	98	2	,	,	PUNCT
admet-831	98	3	many	many	ADJ
admet-831	98	4	proteins	protein	NOUN
admet-831	98	5	do	do	AUX
admet-831	98	6	not	not	PART
admet-831	98	7	aggregate	aggregate	VERB
admet-831	98	8	and	and	CCONJ
admet-831	98	9	during	during	ADP
admet-831	98	10	evolution	evolution	NOUN
admet-831	98	11	have	have	AUX
admet-831	98	12	adapted	adapt	VERB
admet-831	98	13	to	to	PART
admet-831	98	14	prevent	prevent	VERB
admet-831	98	15	amyloid	amyloid	NOUN
admet-831	98	16	formation	formation	NOUN
admet-831	99	1	[	[	X
admet-831	99	2	26	26	NUM
admet-831	99	3	]	]	PUNCT
admet-831	99	4	.	.	PUNCT
admet-831	100	1	chaperones	chaperone	NOUN
admet-831	100	2	that	that	PRON
admet-831	100	3	assist	assist	VERB
admet-831	100	4	proteins	protein	NOUN
admet-831	100	5	to	to	PART
admet-831	100	6	fold	fold	VERB
admet-831	100	7	are	be	AUX
admet-831	100	8	in	in	ADP
admet-831	100	9	central	central	ADJ
admet-831	100	10	role	role	NOUN
admet-831	100	11	[	[	X
admet-831	100	12	27	27	NUM
admet-831	100	13	]	]	PUNCT
admet-831	100	14	.	.	PUNCT
admet-831	101	1	aggregated	aggregate	VERB
admet-831	101	2	proteins	protein	NOUN
admet-831	101	3	form	form	NOUN
admet-831	101	4	either	either	CCONJ
admet-831	101	5	amyloid	amyloid	NOUN
admet-831	101	6	fibrils	fibril	NOUN
admet-831	101	7	,	,	PUNCT
admet-831	101	8	amorphous	amorphous	ADJ
admet-831	101	9	or	or	CCONJ
admet-831	101	10	native	native	ADJ
admet-831	101	11	-	-	PUNCT
admet-831	101	12	like	like	ADJ
admet-831	101	13	deposits	deposit	NOUN
admet-831	101	14	.	.	PUNCT
admet-831	102	1	cpad	cpad	NOUN
admet-831	103	1	[	[	X
admet-831	103	2	28	28	NUM
admet-831	103	3	]	]	PUNCT
admet-831	103	4	,	,	PUNCT
admet-831	103	5	amyload	amyload	NOUN
admet-831	103	6	[	[	X
admet-831	103	7	29	29	NUM
admet-831	103	8	]	]	PUNCT
admet-831	103	9	and	and	CCONJ
admet-831	103	10	amypro	amypro	PROPN
admet-831	104	1	[	[	X
admet-831	104	2	30	30	NUM
admet-831	104	3	]	]	PUNCT
admet-831	104	4	are	be	AUX
admet-831	104	5	databases	database	NOUN
admet-831	104	6	dedicated	dedicate	VERB
admet-831	104	7	for	for	ADP
admet-831	104	8	information	information	NOUN
admet-831	104	9	about	about	ADP
admet-831	104	10	protein	protein	NOUN
admet-831	104	11	aggregation	aggregation	NOUN
admet-831	104	12	.	.	PUNCT
admet-831	105	1	cpad	cpad	NOUN
admet-831	105	2	includes	include	VERB
admet-831	105	3	data	datum	NOUN
admet-831	105	4	for	for	ADP
admet-831	105	5	amyloid	amyloid	NOUN
admet-831	105	6	peptides	peptide	NOUN
admet-831	105	7	,	,	PUNCT
admet-831	105	8	aggregation	aggregation	NOUN
admet-831	105	9	prone	prone	ADJ
admet-831	105	10	peptides	peptide	NOUN
admet-831	105	11	and	and	CCONJ
admet-831	105	12	aggregation	aggregation	NOUN
admet-831	105	13	rates	rate	NOUN
admet-831	105	14	while	while	SCONJ
admet-831	105	15	amyload	amyload	NOUN
admet-831	105	16	contains	contain	VERB
admet-831	105	17	amylodogenic	amylodogenic	ADJ
admet-831	105	18	sequence	sequence	NOUN
admet-831	105	19	information	information	NOUN
admet-831	105	20	.	.	PUNCT
admet-831	106	1	proteins	protein	NOUN
admet-831	106	2	containing	contain	VERB
admet-831	106	3	experimentally	experimentally	ADV
admet-831	106	4	verified	verify	VERB
admet-831	106	5	amyloidogenic	amyloidogenic	ADJ
admet-831	106	6	regions	region	NOUN
admet-831	106	7	are	be	AUX
admet-831	106	8	collected	collect	VERB
admet-831	106	9	to	to	ADP
admet-831	106	10	amypro	amypro	NOUN
admet-831	106	11	.	.	PUNCT
admet-831	107	1	aggregation	aggregation	NOUN
admet-831	107	2	predictors	predictor	NOUN
admet-831	107	3	can	can	AUX
admet-831	107	4	be	be	AUX
admet-831	107	5	grouped	group	VERB
admet-831	107	6	to	to	ADP
admet-831	107	7	two	two	NUM
admet-831	107	8	major	major	ADJ
admet-831	107	9	categories	category	NOUN
admet-831	107	10	:	:	PUNCT
admet-831	107	11	sequence	sequence	NOUN
admet-831	107	12	-	-	PUNCT
admet-831	107	13	based	base	VERB
admet-831	107	14	and	and	CCONJ
admet-831	107	15	three	three	NUM
admet-831	107	16	-	-	PUNCT
admet-831	107	17	dimensional	dimensional	ADJ
admet-831	107	18	structure	structure	NOUN
admet-831	107	19	-	-	PUNCT
admet-831	107	20	based	base	VERB
admet-831	107	21	.	.	PUNCT
admet-831	108	1	the	the	DET
admet-831	108	2	structure	structure	NOUN
admet-831	108	3	-	-	PUNCT
admet-831	108	4	based	base	VERB
admet-831	108	5	methods	method	NOUN
admet-831	108	6	utilize	utilize	VERB
admet-831	108	7	calculations	calculation	NOUN
admet-831	108	8	of	of	ADP
admet-831	108	9	free	free	ADJ
admet-831	108	10	energy	energy	NOUN
admet-831	108	11	difference	difference	NOUN
admet-831	108	12	between	between	ADP
admet-831	108	13	solution	solution	NOUN
admet-831	108	14	and	and	CCONJ
admet-831	108	15	aggregation	aggregation	NOUN
admet-831	108	16	phases	phase	NOUN
admet-831	108	17	,	,	PUNCT
admet-831	108	18	β	β	NOUN
admet-831	108	19	-	-	ADJ
admet-831	108	20	structure	structure	ADJ
admet-831	108	21	formation	formation	NOUN
admet-831	108	22	propensity	propensity	NOUN
admet-831	108	23	,	,	PUNCT
admet-831	108	24	residue	residue	NOUN
admet-831	108	25	exposure	exposure	NOUN
admet-831	108	26	and	and	CCONJ
admet-831	108	27	so	so	ADV
admet-831	108	28	on	on	ADV
admet-831	108	29	.	.	PUNCT
admet-831	109	1	since	since	SCONJ
admet-831	109	2	protein	protein	NOUN
admet-831	109	3	3d	3d	NOUN
admet-831	109	4	structures	structure	NOUN
admet-831	109	5	are	be	AUX
admet-831	109	6	not	not	PART
admet-831	109	7	always	always	ADV
admet-831	109	8	available	available	ADJ
admet-831	109	9	,	,	PUNCT
admet-831	109	10	sequence	sequence	NOUN
admet-831	109	11	-	-	PUNCT
admet-831	109	12	based	base	VERB
admet-831	109	13	methods	method	NOUN
admet-831	109	14	are	be	AUX
admet-831	109	15	needed	need	VERB
admet-831	109	16	,	,	PUNCT
admet-831	109	17	as	as	ADV
admet-831	109	18	well	well	ADV
admet-831	109	19	.	.	PUNCT
admet-831	110	1	machine	machine	NOUN
admet-831	110	2	learning	learn	VERB
admet-831	110	3	methods	method	NOUN
admet-831	110	4	use	use	VERB
admet-831	110	5	features	feature	NOUN
admet-831	110	6	such	such	ADJ
admet-831	110	7	as	as	ADP
admet-831	110	8	amino	amino	NOUN
admet-831	110	9	acid	acid	NOUN
admet-831	110	10	composition	composition	NOUN
admet-831	110	11	and	and	CCONJ
admet-831	110	12	proportions	proportion	NOUN
admet-831	110	13	of	of	ADP
admet-831	110	14	certain	certain	ADJ
admet-831	110	15	amino	amino	NOUN
admet-831	110	16	acid	acid	NOUN
admet-831	110	17	types	type	NOUN
admet-831	110	18	for	for	ADP
admet-831	110	19	training	training	NOUN
admet-831	110	20	.	.	PUNCT
admet-831	111	1	aggregation	aggregation	NOUN
admet-831	111	2	predictors	predictor	NOUN
admet-831	111	3	include	include	VERB
admet-831	111	4	for	for	ADP
admet-831	111	5	example	example	NOUN
admet-831	111	6	aggrescan	aggrescan	NOUN
admet-831	112	1	[	[	X
admet-831	112	2	31	31	NUM
admet-831	112	3	]	]	PUNCT
admet-831	112	4	,	,	PUNCT
admet-831	112	5	aggrescan3d	aggrescan3d	PROPN
admet-831	113	1	[	[	X
admet-831	113	2	32	32	NUM
admet-831	113	3	]	]	PUNCT
admet-831	113	4	,	,	PUNCT
admet-831	113	5	amylpred	amylpre	VERB
admet-831	113	6	[	[	X
admet-831	113	7	33	33	NUM
admet-831	113	8	]	]	PUNCT
admet-831	113	9	,	,	PUNCT
admet-831	113	10	archcandy	archcandy	PROPN
admet-831	114	1	[	[	X
admet-831	114	2	34	34	NUM
admet-831	114	3	]	]	PUNCT
admet-831	114	4	,	,	PUNCT
admet-831	114	5	foldamyloid	foldamyloid	ADJ
admet-831	114	6	[	[	X
admet-831	114	7	35	35	NUM
admet-831	114	8	]	]	PUNCT
admet-831	114	9	,	,	PUNCT
admet-831	114	10	metamyl	metamyl	VERB
admet-831	114	11	[	[	X
admet-831	114	12	36	36	NUM
admet-831	114	13	]	]	PUNCT
admet-831	114	14	,	,	PUNCT
admet-831	114	15	pasta	pasta	NOUN
admet-831	114	16	2.0	2.0	NUM
admet-831	115	1	[	[	SYM
admet-831	115	2	37	37	NUM
admet-831	115	3	]	]	PUNCT
admet-831	115	4	,	,	PUNCT
admet-831	115	5	tango	tango	NOUN
admet-831	116	1	[	[	X
admet-831	116	2	38	38	NUM
admet-831	116	3	]	]	PUNCT
admet-831	116	4	,	,	PUNCT
admet-831	116	5	and	and	CCONJ
admet-831	116	6	waltz	waltz	VERB
admet-831	116	7	[	[	X
admet-831	116	8	39	39	NUM
admet-831	116	9	]	]	PUNCT
admet-831	116	10	.	.	PUNCT
admet-831	117	1	aggrescan3d	aggrescan3d	PROPN
admet-831	117	2	and	and	CCONJ
admet-831	117	3	archcandy	archcandy	ADJ
admet-831	117	4	are	be	AUX
admet-831	117	5	based	base	VERB
admet-831	117	6	on	on	ADP
admet-831	117	7	three	three	NUM
admet-831	117	8	dimensional	dimensional	ADJ
admet-831	117	9	structures	structure	NOUN
admet-831	117	10	,	,	PUNCT
admet-831	117	11	some	some	PRON
admet-831	117	12	of	of	ADP
admet-831	117	13	the	the	DET
admet-831	117	14	others	other	NOUN
admet-831	117	15	use	use	VERB
admet-831	117	16	some	some	DET
admet-831	117	17	structural	structural	ADJ
admet-831	117	18	features	feature	NOUN
admet-831	117	19	,	,	PUNCT
admet-831	117	20	as	as	ADV
admet-831	117	21	well	well	ADV
admet-831	117	22	.	.	PUNCT
admet-831	118	1	admet	admet	PROPN
admet-831	118	2	&	&	CCONJ
admet-831	118	3	dmpk	dmpk	PROPN
admet-831	118	4	8(4	8(4	NOUN
admet-831	118	5	)	)	PUNCT
admet-831	118	6	(	(	PUNCT
admet-831	118	7	2020	2020	NUM
admet-831	118	8	)	)	PUNCT
admet-831	118	9	391	391	NUM
admet-831	118	10	-	-	SYM
admet-831	118	11	399	399	NUM
admet-831	118	12	solubility	solubility	NOUN
admet-831	118	13	of	of	ADP
admet-831	118	14	proteins	protein	NOUN
admet-831	118	15	doi	doi	NOUN
admet-831	118	16	:	:	PUNCT
admet-831	118	17	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PROPN
admet-831	118	18	395	395	NUM
admet-831	118	19	table	table	NOUN
admet-831	118	20	2	2	NUM
admet-831	118	21	.	.	X
admet-831	118	22	protein	protein	NOUN
admet-831	118	23	aggregation	aggregation	NOUN
admet-831	118	24	predictors	predictor	NOUN
admet-831	118	25	aggrescan	aggrescan	NOUN
admet-831	118	26	http://bioinf.uab.es/aggrescan/	http://bioinf.uab.es/aggrescan/	ADP
admet-831	118	27	aggrescan3d	aggrescan3d	PROPN
admet-831	118	28	https://bitbucket.org/lcbio/aggrescan3d/src/master/	https://bitbucket.org/lcbio/aggrescan3d/src/master/	X
admet-831	118	29	amylpred2	amylpred2	ADJ
admet-831	118	30	http://aias.biol.uoa.gr/amylpred2/	http://aias.biol.uoa.gr/amylpred2/	ADJ
admet-831	118	31	archcandy	archcandy	ADJ
admet-831	118	32	https://bioinfo.crbm.cnrs.fr/index.php?route=tools&tool=7&lang=uk	https://bioinfo.crbm.cnrs.fr/index.php?route=tools&tool=7&lang=uk	PROPN
admet-831	118	33	foldamyloid	foldamyloid	ADJ
admet-831	118	34	http://bioinfo.protres.ru/fold-amyloid/	http://bioinfo.protres.ru/fold-amyloid/	NOUN
admet-831	119	1	metamyl	metamyl	VERB
admet-831	119	2	http://metamyl.genouest.org/e107_plugins/metamyl_aggregation/db_prediction_meta.php	http://metamyl.genouest.org/e107_plugins/metamyl_aggregation/db_prediction_meta.php	ADJ
admet-831	119	3	pasta	pasta	NOUN
admet-831	119	4	2.0	2.0	NUM
admet-831	119	5	http://protein.bio.unipd.it/pasta2/help.html	http://protein.bio.unipd.it/pasta2/help.html	NOUN
admet-831	119	6	rfamyloid	rfamyloid	VERB
admet-831	119	7	http://server.malab.cn/rfamyloid/	http://server.malab.cn/rfamyloid/	ADP
admet-831	119	8	tango	tango	NOUN
admet-831	119	9	http://tango.crg.es/	http://tango.crg.es/	PROPN
admet-831	119	10	waltz	waltz	NOUN
admet-831	119	11	https://waltz.switchlab.org/	https://waltz.switchlab.org/	PROPN
admet-831	119	12	amylpred	amylpre	VERB
admet-831	119	13	and	and	CCONJ
admet-831	119	14	metamyl	metamyl	PROPN
admet-831	119	15	are	be	AUX
admet-831	119	16	metapredictors	metapredictor	NOUN
admet-831	119	17	,	,	PUNCT
admet-831	119	18	i.e.	i.e.	X
admet-831	119	19	use	use	VERB
admet-831	119	20	predictions	prediction	NOUN
admet-831	119	21	from	from	ADP
admet-831	119	22	other	other	ADJ
admet-831	119	23	tools	tool	NOUN
admet-831	119	24	.	.	PUNCT
admet-831	120	1	rfamyloid	rfamyloid	NOUN
admet-831	120	2	is	be	AUX
admet-831	120	3	machine	machine	NOUN
admet-831	120	4	learning	learning	NOUN
admet-831	120	5	-	-	PUNCT
admet-831	120	6	based	base	VERB
admet-831	120	7	method	method	NOUN
admet-831	120	8	,	,	PUNCT
admet-831	120	9	waltz	waltz	NOUN
admet-831	120	10	has	have	VERB
admet-831	120	11	a	a	DET
admet-831	120	12	position	position	NOUN
admet-831	120	13	specific	specific	ADJ
admet-831	120	14	scoring	scoring	NOUN
admet-831	120	15	matrix	matrix	NOUN
admet-831	120	16	,	,	PUNCT
admet-831	120	17	the	the	DET
admet-831	120	18	others	other	NOUN
admet-831	120	19	are	be	AUX
admet-831	120	20	based	base	VERB
admet-831	120	21	on	on	ADP
admet-831	120	22	physicochemical	physicochemical	ADJ
admet-831	120	23	propensities	propensity	NOUN
admet-831	120	24	and	and	CCONJ
admet-831	120	25	other	other	ADJ
admet-831	120	26	features	feature	NOUN
admet-831	120	27	including	include	VERB
admet-831	120	28	information	information	NOUN
admet-831	120	29	about	about	ADP
admet-831	120	30	secondary	secondary	ADJ
admet-831	120	31	structural	structural	ADJ
admet-831	120	32	elements	element	NOUN
admet-831	120	33	,	,	PUNCT
admet-831	120	34	amino	amino	NOUN
admet-831	120	35	acid	acid	NOUN
admet-831	120	36	composition	composition	NOUN
admet-831	120	37	,	,	PUNCT
admet-831	120	38	structural	structural	ADJ
admet-831	120	39	features	feature	NOUN
admet-831	120	40	,	,	PUNCT
admet-831	120	41	physicochemical	physicochemical	ADJ
admet-831	120	42	propensities	propensity	NOUN
admet-831	120	43	of	of	ADP
admet-831	120	44	amino	amino	ADJ
admet-831	120	45	acids	acid	NOUN
admet-831	120	46	,	,	PUNCT
admet-831	120	47	packing	pack	VERB
admet-831	120	48	density	density	NOUN
admet-831	120	49	,	,	PUNCT
admet-831	120	50	hydrogen	hydrogen	NOUN
admet-831	120	51	bonds	bond	NOUN
admet-831	120	52	etc	etc	X
admet-831	120	53	.	.	X
admet-831	120	54	neural	neural	ADJ
admet-831	120	55	network	network	NOUN
admet-831	120	56	tool	tool	NOUN
admet-831	120	57	for	for	ADP
admet-831	120	58	amyloid	amyloid	NOUN
admet-831	120	59	aggregation	aggregation	NOUN
admet-831	120	60	rate	rate	NOUN
admet-831	120	61	prediction	prediction	NOUN
admet-831	120	62	is	be	AUX
admet-831	120	63	a	a	DET
admet-831	120	64	related	related	ADJ
admet-831	120	65	application	application	NOUN
admet-831	121	1	[	[	X
admet-831	121	2	40	40	NUM
admet-831	121	3	]	]	PUNCT
admet-831	121	4	.	.	PUNCT
admet-831	122	1	some	some	PRON
admet-831	122	2	of	of	ADP
admet-831	122	3	the	the	DET
admet-831	122	4	methods	method	NOUN
admet-831	122	5	can	can	AUX
admet-831	122	6	be	be	AUX
admet-831	122	7	used	use	VERB
admet-831	122	8	both	both	PRON
admet-831	122	9	for	for	ADP
admet-831	122	10	solubility	solubility	NOUN
admet-831	122	11	and	and	CCONJ
admet-831	122	12	aggregation	aggregation	NOUN
admet-831	122	13	prediction	prediction	NOUN
admet-831	122	14	,	,	PUNCT
admet-831	122	15	such	such	ADJ
admet-831	122	16	as	as	ADP
admet-831	122	17	solart	solart	NOUN
admet-831	122	18	[	[	X
admet-831	122	19	15	15	NUM
admet-831	122	20	]	]	PUNCT
admet-831	122	21	.	.	PUNCT
admet-831	123	1	soda	soda	NOUN
admet-831	123	2	,	,	PUNCT
admet-831	123	3	a	a	DET
admet-831	123	4	solubility	solubility	NOUN
admet-831	123	5	predictor	predictor	NOUN
admet-831	123	6	,	,	PUNCT
admet-831	123	7	utilizes	utilize	VERB
admet-831	123	8	aggregation	aggregation	NOUN
admet-831	123	9	and	and	CCONJ
admet-831	123	10	disorder	disorder	NOUN
admet-831	123	11	propensities	propensity	NOUN
admet-831	123	12	[	[	X
admet-831	123	13	14	14	NUM
admet-831	123	14	]	]	PUNCT
admet-831	123	15	.	.	PUNCT
admet-831	124	1	systematic	systematic	ADJ
admet-831	124	2	independent	independent	ADJ
admet-831	124	3	method	method	NOUN
admet-831	124	4	performance	performance	NOUN
admet-831	124	5	assessments	assessment	NOUN
admet-831	124	6	are	be	AUX
admet-831	124	7	missing	miss	VERB
admet-831	124	8	.	.	PUNCT
admet-831	125	1	some	some	DET
admet-831	125	2	recent	recent	ADJ
admet-831	125	3	studies	study	NOUN
admet-831	125	4	contain	contain	VERB
admet-831	125	5	comparisons	comparison	NOUN
admet-831	125	6	of	of	ADP
admet-831	125	7	several	several	ADJ
admet-831	125	8	methods	method	NOUN
admet-831	125	9	.	.	PUNCT
admet-831	126	1	pasta	pasta	NOUN
admet-831	126	2	2.0	2.0	NUM
admet-831	126	3	was	be	AUX
admet-831	126	4	compared	compare	VERB
admet-831	126	5	to	to	ADP
admet-831	126	6	eight	eight	NUM
admet-831	126	7	methods	method	NOUN
admet-831	126	8	,	,	PUNCT
admet-831	126	9	showing	show	VERB
admet-831	126	10	the	the	DET
admet-831	126	11	best	good	ADJ
admet-831	126	12	performance	performance	NOUN
admet-831	126	13	(	(	PUNCT
admet-831	126	14	mcc	mcc	NOUN
admet-831	126	15	0.24	0.24	NUM
admet-831	126	16	)	)	PUNCT
admet-831	126	17	along	along	ADP
admet-831	126	18	with	with	ADP
admet-831	126	19	amylpred	amylpre	VERB
admet-831	126	20	2	2	NUM
admet-831	126	21	(	(	PUNCT
admet-831	126	22	0.22	0.22	NUM
admet-831	126	23	)	)	PUNCT
admet-831	126	24	and	and	CCONJ
admet-831	126	25	metamyl	metamyl	PROPN
admet-831	126	26	(	(	PUNCT
admet-831	126	27	0.19	0.19	NUM
admet-831	126	28	)	)	PUNCT
admet-831	127	1	[	[	X
admet-831	127	2	37	37	NUM
admet-831	127	3	]	]	PUNCT
admet-831	127	4	.	.	PUNCT
admet-831	128	1	however	however	ADV
admet-831	128	2	,	,	PUNCT
admet-831	128	3	the	the	DET
admet-831	128	4	performances	performance	NOUN
admet-831	128	5	are	be	AUX
admet-831	128	6	not	not	PART
admet-831	128	7	very	very	ADV
admet-831	128	8	high	high	ADJ
admet-831	128	9	,	,	PUNCT
admet-831	128	10	specificity	specificity	NOUN
admet-831	128	11	being	be	AUX
admet-831	128	12	clearly	clearly	ADV
admet-831	128	13	better	well	ADJ
admet-831	128	14	than	than	ADP
admet-831	128	15	sensitivity	sensitivity	NOUN
admet-831	128	16	for	for	ADP
admet-831	128	17	all	all	DET
admet-831	128	18	the	the	DET
admet-831	128	19	tools	tool	NOUN
admet-831	128	20	,	,	PUNCT
admet-831	128	21	the	the	DET
admet-831	128	22	best	good	ADJ
admet-831	128	23	matthews	matthews	NOUN
admet-831	128	24	correlation	correlation	NOUN
admet-831	128	25	coefficient	coefficient	NOUN
admet-831	128	26	being	be	AUX
admet-831	128	27	only	only	ADV
admet-831	128	28	0.24	0.24	NUM
admet-831	128	29	.	.	PUNCT
admet-831	129	1	developers	developer	NOUN
admet-831	129	2	of	of	ADP
admet-831	129	3	archcandy	archcandy	ADJ
admet-831	129	4	saw	see	VERB
admet-831	129	5	really	really	ADV
admet-831	129	6	big	big	ADJ
admet-831	129	7	differences	difference	NOUN
admet-831	129	8	in	in	ADP
admet-831	129	9	performances	performance	NOUN
admet-831	129	10	for	for	ADP
admet-831	129	11	six	six	NUM
admet-831	129	12	predictors	predictor	NOUN
admet-831	129	13	[	[	X
admet-831	129	14	41	41	NUM
admet-831	129	15	]	]	PUNCT
admet-831	129	16	,	,	PUNCT
admet-831	129	17	their	their	PRON
admet-831	129	18	own	own	ADJ
admet-831	129	19	tool	tool	NOUN
admet-831	129	20	(	(	PUNCT
admet-831	129	21	error	error	NOUN
admet-831	129	22	rate	rate	NOUN
admet-831	129	23	for	for	ADP
admet-831	129	24	amyloid	amyloid	NOUN
admet-831	129	25	prediction	prediction	NOUN
admet-831	129	26	1.4	1.4	NUM
admet-831	129	27	%	%	NOUN
admet-831	129	28	)	)	PUNCT
admet-831	129	29	along	along	ADP
admet-831	129	30	with	with	ADP
admet-831	129	31	pasta	pasta	NOUN
admet-831	129	32	(	(	PUNCT
admet-831	129	33	4.2	4.2	NUM
admet-831	129	34	%	%	NOUN
admet-831	129	35	)	)	PUNCT
admet-831	129	36	,	,	PUNCT
admet-831	129	37	tango	tango	NOUN
admet-831	129	38	(	(	PUNCT
admet-831	129	39	5.0	5.0	NUM
admet-831	129	40	%	%	NOUN
admet-831	129	41	)	)	PUNCT
admet-831	129	42	and	and	CCONJ
admet-831	129	43	waltz	waltz	NOUN
admet-831	129	44	(	(	PUNCT
admet-831	129	45	11.4	11.4	NUM
admet-831	129	46	%	%	NOUN
admet-831	129	47	)	)	PUNCT
admet-831	129	48	being	be	AUX
admet-831	129	49	the	the	DET
admet-831	129	50	best	good	ADJ
admet-831	129	51	.	.	PUNCT
admet-831	130	1	this	this	DET
admet-831	130	2	test	test	NOUN
admet-831	130	3	contained	contain	VERB
admet-831	130	4	only	only	ADV
admet-831	130	5	soluble	soluble	ADJ
admet-831	130	6	segments	segment	NOUN
admet-831	130	7	of	of	ADP
admet-831	130	8	15	15	NUM
admet-831	130	9	residues	residue	NOUN
admet-831	130	10	or	or	CCONJ
admet-831	130	11	longer	long	ADJ
admet-831	130	12	.	.	PUNCT
admet-831	131	1	they	they	PRON
admet-831	131	2	were	be	AUX
admet-831	131	3	collected	collect	VERB
admet-831	131	4	from	from	ADP
admet-831	131	5	three	three	NUM
admet-831	131	6	-	-	PUNCT
admet-831	131	7	dimensional	dimensional	ADJ
admet-831	131	8	protein	protein	NOUN
admet-831	131	9	structures	structure	NOUN
admet-831	131	10	determined	determine	VERB
admet-831	131	11	with	with	ADP
admet-831	131	12	nmr	nmr	NOUN
admet-831	131	13	,	,	PUNCT
admet-831	131	14	thus	thus	ADV
admet-831	131	15	the	the	DET
admet-831	131	16	proteins	protein	NOUN
admet-831	131	17	are	be	AUX
admet-831	131	18	soluble	soluble	ADJ
admet-831	131	19	,	,	PUNCT
admet-831	131	20	however	however	ADV
admet-831	131	21	contained	contain	VERB
admet-831	131	22	highly	highly	ADV
admet-831	131	23	flexible	flexible	ADJ
admet-831	131	24	regions	region	NOUN
admet-831	131	25	without	without	ADP
admet-831	131	26	ordered	order	VERB
admet-831	131	27	structures	structure	NOUN
admet-831	131	28	,	,	PUNCT
admet-831	131	29	typically	typically	ADV
admet-831	131	30	in	in	ADP
admet-831	131	31	the	the	DET
admet-831	131	32	termini	termini	NOUN
admet-831	131	33	.	.	PUNCT
admet-831	132	1	comprehensive	comprehensive	ADJ
admet-831	132	2	performance	performance	NOUN
admet-831	132	3	assessment	assessment	NOUN
admet-831	132	4	would	would	AUX
admet-831	132	5	require	require	VERB
admet-831	132	6	both	both	CCONJ
admet-831	132	7	positive	positive	ADJ
admet-831	132	8	and	and	CCONJ
admet-831	132	9	negative	negative	ADJ
admet-831	132	10	cases	case	NOUN
admet-831	132	11	[	[	X
admet-831	132	12	20	20	NUM
admet-831	132	13	,	,	PUNCT
admet-831	132	14	21	21	NUM
admet-831	132	15	]	]	PUNCT
admet-831	132	16	,	,	PUNCT
admet-831	132	17	thereby	thereby	ADV
admet-831	132	18	we	we	PRON
admet-831	132	19	do	do	AUX
admet-831	132	20	not	not	PART
admet-831	132	21	know	know	VERB
admet-831	132	22	if	if	SCONJ
admet-831	132	23	the	the	DET
admet-831	132	24	best	good	ADJ
admet-831	132	25	methods	method	NOUN
admet-831	132	26	are	be	AUX
admet-831	132	27	overpredicting	overpredicte	VERB
admet-831	132	28	soluble	soluble	ADJ
admet-831	132	29	regions	region	NOUN
admet-831	132	30	and	and	CCONJ
admet-831	132	31	underpredicting	underpredicte	VERB
admet-831	132	32	aggregation	aggregation	NOUN
admet-831	132	33	-	-	PUNCT
admet-831	132	34	prone	prone	ADJ
admet-831	132	35	segments	segment	NOUN
admet-831	132	36	.	.	PUNCT
admet-831	133	1	prediction	prediction	NOUN
admet-831	133	2	of	of	ADP
admet-831	133	3	solubility	solubility	NOUN
admet-831	133	4	and	and	CCONJ
admet-831	133	5	aggregation	aggregation	NOUN
admet-831	133	6	affecting	affect	VERB
admet-831	133	7	variants	variant	NOUN
admet-831	133	8	the	the	DET
admet-831	133	9	tools	tool	NOUN
admet-831	133	10	described	describe	VERB
admet-831	133	11	above	above	ADV
admet-831	133	12	are	be	AUX
admet-831	133	13	for	for	ADP
admet-831	133	14	predictions	prediction	NOUN
admet-831	133	15	on	on	ADP
admet-831	133	16	entire	entire	ADJ
admet-831	133	17	proteins	protein	NOUN
admet-831	133	18	or	or	CCONJ
admet-831	133	19	polypeptides	polypeptide	NOUN
admet-831	133	20	.	.	PUNCT
admet-831	134	1	much	much	ADV
admet-831	134	2	less	less	ADJ
admet-831	134	3	effort	effort	NOUN
admet-831	134	4	has	have	AUX
admet-831	134	5	been	be	AUX
admet-831	134	6	put	put	VERB
admet-831	134	7	on	on	ADP
admet-831	134	8	predicting	predict	VERB
admet-831	134	9	the	the	DET
admet-831	134	10	effect	effect	NOUN
admet-831	134	11	of	of	ADP
admet-831	134	12	variations	variation	NOUN
admet-831	134	13	on	on	ADP
admet-831	134	14	solubility	solubility	NOUN
admet-831	134	15	or	or	CCONJ
admet-831	134	16	aggregation	aggregation	NOUN
admet-831	134	17	.	.	PUNCT
admet-831	135	1	we	we	PRON
admet-831	135	2	are	be	AUX
admet-831	135	3	looking	look	VERB
admet-831	135	4	at	at	ADP
admet-831	135	5	tools	tool	NOUN
admet-831	135	6	predicting	predict	VERB
admet-831	135	7	consequences	consequence	NOUN
admet-831	135	8	of	of	ADP
admet-831	135	9	amino	amino	NOUN
admet-831	135	10	acid	acid	NOUN
admet-831	135	11	substitutions	substitution	NOUN
admet-831	135	12	as	as	SCONJ
admet-831	135	13	there	there	PRON
admet-831	135	14	is	be	VERB
admet-831	135	15	not	not	PART
admet-831	135	16	enough	enough	ADJ
admet-831	135	17	data	datum	NOUN
admet-831	135	18	for	for	ADP
admet-831	135	19	other	other	ADJ
admet-831	135	20	types	type	NOUN
admet-831	135	21	of	of	ADP
admet-831	135	22	variations	variation	NOUN
admet-831	135	23	.	.	PUNCT
admet-831	136	1	single	single	ADJ
admet-831	136	2	amino	amino	NOUN
admet-831	136	3	acid	acid	NOUN
admet-831	136	4	alterations	alteration	NOUN
admet-831	136	5	can	can	AUX
admet-831	136	6	have	have	VERB
admet-831	136	7	profound	profound	ADJ
admet-831	136	8	effects	effect	NOUN
admet-831	136	9	of	of	ADP
admet-831	136	10	solubility	solubility	NOUN
admet-831	136	11	and	and	CCONJ
admet-831	136	12	lead	lead	VERB
admet-831	136	13	to	to	ADP
admet-831	136	14	diseases	disease	NOUN
admet-831	136	15	,	,	PUNCT
admet-831	136	16	including	include	VERB
admet-831	136	17	severe	severe	ADJ
admet-831	136	18	complex	complex	ADJ
admet-831	136	19	v	v	NOUN
admet-831	136	20	deficiency	deficiency	NOUN
admet-831	136	21	[	[	X
admet-831	136	22	42	42	NUM
admet-831	136	23	]	]	PUNCT
admet-831	136	24	and	and	CCONJ
admet-831	136	25	cataract	cataract	VERB
admet-831	137	1	[	[	X
admet-831	137	2	43	43	NUM
admet-831	137	3	]	]	PUNCT
admet-831	137	4	.	.	PUNCT
admet-831	138	1	protein	protein	NOUN
admet-831	138	2	solubility	solubility	NOUN
admet-831	138	3	and	and	CCONJ
admet-831	138	4	aggregation	aggregation	NOUN
admet-831	138	5	are	be	AUX
admet-831	138	6	mechanisms	mechanism	NOUN
admet-831	138	7	in	in	ADP
admet-831	138	8	diseases	disease	NOUN
admet-831	138	9	,	,	PUNCT
admet-831	138	10	including	include	VERB
admet-831	138	11	cancers	cancer	NOUN
admet-831	138	12	[	[	X
admet-831	138	13	44	44	NUM
admet-831	138	14	,	,	PUNCT
admet-831	138	15	45	45	NUM
admet-831	138	16	]	]	PUNCT
admet-831	138	17	.	.	PUNCT
admet-831	139	1	predictors	predictor	NOUN
admet-831	139	2	for	for	ADP
admet-831	139	3	solubility	solubility	NOUN
admet-831	139	4	affecting	affect	VERB
admet-831	139	5	variants	variant	NOUN
admet-831	139	6	include	include	VERB
admet-831	139	7	camsol	camsol	VERB
admet-831	139	8	[	[	X
admet-831	139	9	46	46	NUM
admet-831	139	10	]	]	PUNCT
admet-831	139	11	,	,	PUNCT
admet-831	139	12	optsolmut	optsolmut	NOUN
admet-831	140	1	[	[	X
admet-831	140	2	47	47	NUM
admet-831	140	3	]	]	PUNCT
admet-831	140	4	,	,	PUNCT
admet-831	140	5	pon	pon	NOUN
admet-831	140	6	-	-	NOUN
admet-831	140	7	sol	sol	NOUN
admet-831	141	1	[	[	X
admet-831	141	2	4	4	NUM
admet-831	141	3	]	]	PUNCT
admet-831	141	4	,	,	PUNCT
admet-831	141	5	soda	soda	NOUN
admet-831	141	6	[	[	X
admet-831	141	7	14	14	NUM
admet-831	141	8	]	]	PUNCT
admet-831	141	9	and	and	CCONJ
admet-831	141	10	solubis	solubis	VERB
admet-831	142	1	[	[	X
admet-831	142	2	48	48	NUM
admet-831	142	3	]	]	PUNCT
admet-831	142	4	.	.	PUNCT
admet-831	143	1	camsol	camsol	PROPN
admet-831	143	2	uses	use	VERB
admet-831	143	3	residue	residue	NOUN
admet-831	143	4	-	-	PUNCT
admet-831	143	5	specific	specific	ADJ
admet-831	143	6	solubility	solubility	NOUN
admet-831	143	7	profile	profile	NOUN
admet-831	143	8	.	.	PUNCT
admet-831	144	1	the	the	DET
admet-831	144	2	method	method	NOUN
admet-831	144	3	is	be	AUX
admet-831	144	4	not	not	PART
admet-831	144	5	available	available	ADJ
admet-831	144	6	as	as	ADP
admet-831	144	7	a	a	DET
admet-831	144	8	tool	tool	NOUN
admet-831	144	9	,	,	PUNCT
admet-831	144	10	only	only	ADV
admet-831	144	11	the	the	DET
admet-831	144	12	algorithm	algorithm	NOUN
admet-831	144	13	has	have	AUX
admet-831	144	14	been	be	AUX
admet-831	144	15	described	describe	VERB
admet-831	144	16	.	.	PUNCT
admet-831	145	1	optsolmut	optsolmut	NOUN
admet-831	145	2	has	have	AUX
admet-831	145	3	been	be	AUX
admet-831	145	4	trained	train	VERB
admet-831	145	5	with	with	ADP
admet-831	145	6	a	a	DET
admet-831	145	7	small	small	ADJ
admet-831	145	8	dataset	dataset	NOUN
admet-831	145	9	that	that	PRON
admet-831	145	10	contains	contain	VERB
admet-831	145	11	also	also	ADV
admet-831	145	12	aggregation	aggregation	NOUN
admet-831	145	13	cases	case	NOUN
admet-831	145	14	.	.	PUNCT
admet-831	146	1	weights	weight	NOUN
admet-831	146	2	for	for	ADP
admet-831	146	3	scoring	scoring	NOUN
admet-831	146	4	function	function	NOUN
admet-831	146	5	were	be	AUX
admet-831	146	6	optimized	optimize	VERB
admet-831	146	7	with	with	ADP
admet-831	146	8	linear	linear	ADJ
admet-831	146	9	programming	programming	NOUN
admet-831	146	10	for	for	ADP
admet-831	146	11	137	137	NUM
admet-831	146	12	cases	case	NOUN
admet-831	146	13	of	of	ADP
admet-831	146	14	single	single	ADJ
admet-831	146	15	and	and	CCONJ
admet-831	146	16	multiple	multiple	ADJ
admet-831	146	17	variants	variant	NOUN
admet-831	146	18	.	.	PUNCT
admet-831	147	1	pon	pon	PROPN
admet-831	147	2	-	-	PUNCT
admet-831	147	3	sol	sol	NOUN
admet-831	147	4	is	be	AUX
admet-831	147	5	a	a	DET
admet-831	147	6	random	random	ADJ
admet-831	147	7	forest	forest	NOUN
admet-831	147	8	-	-	PUNCT
admet-831	147	9	based	base	VERB
admet-831	147	10	machine	machine	NOUN
admet-831	147	11	learning	learning	NOUN
admet-831	147	12	method	method	NOUN
admet-831	147	13	.	.	PUNCT
admet-831	148	1	it	it	PRON
admet-831	148	2	was	be	AUX
admet-831	148	3	trained	train	VERB
admet-831	148	4	and	and	CCONJ
admet-831	148	5	tested	test	VERB
admet-831	148	6	on	on	ADP
admet-831	148	7	406	406	NUM
admet-831	148	8	single	single	ADJ
admet-831	148	9	amino	amino	NOUN
admet-831	148	10	acid	acid	NOUN
admet-831	148	11	substitutions	substitution	NOUN
admet-831	148	12	for	for	ADP
admet-831	148	13	which	which	PRON
admet-831	148	14	solubility	solubility	NOUN
admet-831	148	15	effect	effect	NOUN
admet-831	148	16	have	have	AUX
admet-831	148	17	been	be	AUX
admet-831	148	18	experimentally	experimentally	ADV
admet-831	149	1	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	ADJ
admet-831	149	2	http://bioinf.uab.es/aggrescan/	http://bioinf.uab.es/aggrescan/	ADP
admet-831	149	3	https://bitbucket.org/lcbio/aggrescan3d/src/master/	https://bitbucket.org/lcbio/aggrescan3d/src/master/	PROPN
admet-831	149	4	http://aias.biol.uoa.gr/amylpred2/	http://aias.biol.uoa.gr/amylpred2/	PROPN
admet-831	149	5	https://bioinfo.crbm.cnrs.fr/index.php?route=tools&tool=7&lang=uk	https://bioinfo.crbm.cnrs.fr/index.php?route=tools&tool=7&lang=uk	PROPN
admet-831	149	6	http://bioinfo.protres.ru/fold-amyloid/	http://bioinfo.protres.ru/fold-amyloid/	NOUN
admet-831	149	7	http://metamyl.genouest.org/e107_plugins/metamyl_aggregation/db_prediction_meta.php	http://metamyl.genouest.org/e107_plugins/metamyl_aggregation/db_prediction_meta.php	VERB
admet-831	149	8	http://protein.bio.unipd.it/pasta2/help.html	http://protein.bio.unipd.it/pasta2/help.html	PROPN
admet-831	150	1	http://server.malab.cn/rfamyloid/	http://server.malab.cn/rfamyloid/	ADP
admet-831	150	2	http://tango.crg.es/	http://tango.crg.es/	PROPN
admet-831	150	3	https://waltz.switchlab.org/	https://waltz.switchlab.org/	VERB
admet-831	150	4	mauno	mauno	PROPN
admet-831	150	5	vihinen	vihinen	PROPN
admet-831	150	6	admet	admet	PROPN
admet-831	150	7	&	&	CCONJ
admet-831	150	8	dmpk	dmpk	PROPN
admet-831	150	9	8(4	8(4	NOUN
admet-831	150	10	)	)	PUNCT
admet-831	150	11	(	(	PUNCT
admet-831	150	12	2020	2020	NUM
admet-831	150	13	)	)	PUNCT
admet-831	150	14	391	391	NUM
admet-831	150	15	-	-	SYM
admet-831	150	16	399	399	NUM
admet-831	150	17	396	396	NUM
admet-831	150	18	determined	determine	VERB
admet-831	150	19	.	.	PUNCT
admet-831	151	1	it	it	PRON
admet-831	151	2	predicts	predict	VERB
admet-831	151	3	variants	variant	NOUN
admet-831	151	4	into	into	ADP
admet-831	151	5	three	three	NUM
admet-831	151	6	classes	class	NOUN
admet-831	151	7	:	:	PUNCT
admet-831	151	8	solubility	solubility	NOUN
admet-831	151	9	decreasing	decrease	VERB
admet-831	151	10	and	and	CCONJ
admet-831	151	11	increasing	increase	VERB
admet-831	151	12	variants	variant	NOUN
admet-831	151	13	and	and	CCONJ
admet-831	151	14	those	those	PRON
admet-831	151	15	not	not	PART
admet-831	151	16	affecting	affect	VERB
admet-831	151	17	solubility	solubility	NOUN
admet-831	151	18	.	.	PUNCT
admet-831	152	1	this	this	PRON
admet-831	152	2	is	be	AUX
admet-831	152	3	a	a	DET
admet-831	152	4	more	more	ADV
admet-831	152	5	realistic	realistic	ADJ
admet-831	152	6	scenario	scenario	NOUN
admet-831	152	7	than	than	ADP
admet-831	152	8	binary	binary	ADJ
admet-831	152	9	prediction	prediction	NOUN
admet-831	152	10	.	.	PUNCT
admet-831	153	1	in	in	ADP
admet-831	153	2	the	the	DET
admet-831	153	3	three	three	NUM
admet-831	153	4	-	-	PUNCT
admet-831	153	5	state	state	NOUN
admet-831	153	6	prediction	prediction	NOUN
admet-831	153	7	pon	pon	NOUN
admet-831	153	8	-	-	PUNCT
admet-831	153	9	sol	sol	NOUN
admet-831	153	10	had	have	VERB
admet-831	153	11	correct	correct	ADJ
admet-831	153	12	prediction	prediction	NOUN
admet-831	153	13	ratio	ratio	NOUN
admet-831	153	14	of	of	ADP
admet-831	153	15	0.597	0.597	NUM
admet-831	153	16	on	on	ADP
admet-831	153	17	cross	cross	NOUN
admet-831	153	18	validation	validation	NOUN
admet-831	153	19	and	and	CCONJ
admet-831	153	20	0.488	0.488	NUM
admet-831	153	21	for	for	ADP
admet-831	153	22	independent	independent	ADJ
admet-831	153	23	test	test	NOUN
admet-831	153	24	set	set	NOUN
admet-831	153	25	(	(	PUNCT
admet-831	153	26	note	note	VERB
admet-831	153	27	that	that	SCONJ
admet-831	153	28	random	random	ADJ
admet-831	153	29	prediction	prediction	NOUN
admet-831	153	30	has	have	VERB
admet-831	153	31	a	a	DET
admet-831	153	32	score	score	NOUN
admet-831	153	33	of	of	ADP
admet-831	153	34	0.33	0.33	NUM
admet-831	153	35	)	)	PUNCT
admet-831	153	36	.	.	PUNCT
admet-831	154	1	thus	thus	ADV
admet-831	154	2	,	,	PUNCT
admet-831	154	3	there	there	PRON
admet-831	154	4	is	be	VERB
admet-831	154	5	still	still	ADV
admet-831	154	6	place	place	NOUN
admet-831	154	7	for	for	ADP
admet-831	154	8	substantial	substantial	ADJ
admet-831	154	9	improvements	improvement	NOUN
admet-831	154	10	.	.	PUNCT
admet-831	155	1	the	the	DET
admet-831	155	2	method	method	PROPN
admet-831	155	3	development	development	NOUN
admet-831	155	4	has	have	AUX
admet-831	155	5	been	be	AUX
admet-831	155	6	hampered	hamper	VERB
admet-831	155	7	by	by	ADP
admet-831	155	8	small	small	ADJ
admet-831	155	9	number	number	NOUN
admet-831	155	10	of	of	ADP
admet-831	155	11	known	know	VERB
admet-831	155	12	solubility	solubility	NOUN
admet-831	155	13	-	-	PUNCT
admet-831	155	14	affecting	affect	VERB
admet-831	155	15	variants	variant	NOUN
admet-831	155	16	.	.	PUNCT
admet-831	156	1	pon	pon	PROPN
admet-831	156	2	-	-	PUNCT
admet-831	156	3	sol	sol	NOUN
admet-831	156	4	is	be	AUX
admet-831	156	5	no	no	PRON
admet-831	156	6	more	more	ADV
admet-831	156	7	available	available	ADJ
admet-831	156	8	;	;	PUNCT
admet-831	156	9	however	however	ADV
admet-831	156	10	,	,	PUNCT
admet-831	156	11	a	a	DET
admet-831	156	12	new	new	ADJ
admet-831	156	13	extended	extended	ADJ
admet-831	156	14	and	and	CCONJ
admet-831	156	15	improved	improve	VERB
admet-831	156	16	version	version	NOUN
admet-831	156	17	will	will	AUX
admet-831	156	18	be	be	AUX
admet-831	156	19	released	release	VERB
admet-831	156	20	soon	soon	ADV
admet-831	156	21	.	.	PUNCT
admet-831	157	1	soda	soda	NOUN
admet-831	157	2	has	have	AUX
admet-831	157	3	been	be	AUX
admet-831	157	4	recommended	recommend	VERB
admet-831	157	5	to	to	PART
admet-831	157	6	predict	predict	VERB
admet-831	157	7	variants	variant	NOUN
admet-831	157	8	decreasing	decrease	VERB
admet-831	157	9	solubility	solubility	NOUN
admet-831	158	1	[	[	X
admet-831	158	2	14	14	NUM
admet-831	158	3	]	]	PUNCT
admet-831	158	4	.	.	PUNCT
admet-831	159	1	it	it	PRON
admet-831	159	2	was	be	AUX
admet-831	159	3	developed	develop	VERB
admet-831	159	4	with	with	ADP
admet-831	159	5	pon	pon	ADJ
admet-831	159	6	-	-	PUNCT
admet-831	159	7	sol	sol	NOUN
admet-831	159	8	data	datum	NOUN
admet-831	159	9	.	.	PUNCT
admet-831	160	1	these	these	DET
admet-831	160	2	methods	method	NOUN
admet-831	160	3	can	can	AUX
admet-831	160	4	be	be	AUX
admet-831	160	5	used	use	VERB
admet-831	160	6	for	for	ADP
admet-831	160	7	numerous	numerous	ADJ
admet-831	160	8	purposes	purpose	NOUN
admet-831	160	9	including	include	VERB
admet-831	160	10	identification	identification	NOUN
admet-831	160	11	of	of	ADP
admet-831	160	12	disease	disease	NOUN
admet-831	160	13	related	relate	VERB
admet-831	160	14	amino	amino	NOUN
admet-831	160	15	acid	acid	NOUN
admet-831	160	16	substitutions	substitution	NOUN
admet-831	160	17	,	,	PUNCT
admet-831	160	18	predictions	prediction	NOUN
admet-831	160	19	of	of	ADP
admet-831	160	20	solubility	solubility	NOUN
admet-831	160	21	of	of	ADP
admet-831	160	22	heterologous	heterologous	ADJ
admet-831	160	23	recombinant	recombinant	ADJ
admet-831	160	24	protein	protein	NOUN
admet-831	160	25	expression	expression	NOUN
admet-831	160	26	and	and	CCONJ
admet-831	160	27	enhanced	enhanced	ADJ
admet-831	160	28	crystallizability	crystallizability	NOUN
admet-831	160	29	.	.	PUNCT
admet-831	161	1	of	of	ADP
admet-831	161	2	the	the	DET
admet-831	161	3	aggregation	aggregation	NOUN
admet-831	161	4	prediction	prediction	NOUN
admet-831	161	5	tools	tool	NOUN
admet-831	161	6	,	,	PUNCT
admet-831	161	7	pasta	pasta	NOUN
admet-831	161	8	2.0	2.0	NUM
admet-831	161	9	can	can	AUX
admet-831	161	10	predict	predict	VERB
admet-831	161	11	also	also	ADV
admet-831	161	12	effects	effect	NOUN
admet-831	161	13	of	of	ADP
admet-831	161	14	amino	amino	NOUN
admet-831	161	15	acid	acid	NOUN
admet-831	161	16	substitutions	substitution	NOUN
admet-831	161	17	.	.	PUNCT
admet-831	162	1	solubis	solubis	PROPN
admet-831	162	2	has	have	VERB
admet-831	162	3	a	a	DET
admet-831	162	4	somewhat	somewhat	ADV
admet-831	162	5	different	different	ADJ
admet-831	162	6	application	application	NOUN
admet-831	162	7	,	,	PUNCT
admet-831	162	8	optimization	optimization	NOUN
admet-831	162	9	of	of	ADP
admet-831	162	10	multiple	multiple	ADJ
admet-831	162	11	variants	variant	NOUN
admet-831	162	12	to	to	PART
admet-831	162	13	increase	increase	VERB
admet-831	162	14	protein	protein	NOUN
admet-831	162	15	solubility	solubility	NOUN
admet-831	162	16	[	[	X
admet-831	162	17	48	48	NUM
admet-831	162	18	]	]	PUNCT
admet-831	162	19	.	.	PUNCT
admet-831	163	1	it	it	PRON
admet-831	163	2	detects	detect	VERB
admet-831	163	3	aggregation	aggregation	NOUN
admet-831	163	4	prone	prone	ADJ
admet-831	163	5	segments	segment	NOUN
admet-831	163	6	and	and	CCONJ
admet-831	163	7	then	then	ADV
admet-831	163	8	suggests	suggest	VERB
admet-831	163	9	variants	variant	NOUN
admet-831	163	10	to	to	PART
admet-831	163	11	modify	modify	VERB
admet-831	163	12	them	they	PRON
admet-831	163	13	.	.	PUNCT
admet-831	164	1	so	so	ADV
admet-831	164	2	,	,	PUNCT
admet-831	164	3	actually	actually	ADV
admet-831	164	4	it	it	PRON
admet-831	164	5	is	be	AUX
admet-831	164	6	an	an	DET
admet-831	164	7	aggregation	aggregation	NOUN
admet-831	164	8	prevention	prevention	NOUN
admet-831	164	9	predictor	predictor	NOUN
admet-831	164	10	.	.	PUNCT
admet-831	165	1	it	it	PRON
admet-831	165	2	combines	combine	VERB
admet-831	165	3	predictions	prediction	NOUN
admet-831	165	4	from	from	ADP
admet-831	165	5	interaction	interaction	NOUN
admet-831	165	6	analysis	analysis	NOUN
admet-831	165	7	tool	tool	NOUN
admet-831	165	8	foldx	foldx	NOUN
admet-831	165	9	[	[	X
admet-831	165	10	49	49	NUM
admet-831	165	11	]	]	PUNCT
admet-831	165	12	,	,	PUNCT
admet-831	165	13	aggregation	aggregation	NOUN
admet-831	165	14	predictor	predictor	NOUN
admet-831	165	15	tango	tango	NOUN
admet-831	166	1	[	[	X
admet-831	166	2	38	38	NUM
admet-831	166	3	]	]	PUNCT
admet-831	166	4	and	and	CCONJ
admet-831	166	5	structural	structural	ADJ
admet-831	166	6	analysis	analysis	NOUN
admet-831	166	7	with	with	ADP
admet-831	166	8	yasara	yasara	NOUN
admet-831	167	1	[	[	X
admet-831	167	2	50	50	NUM
admet-831	167	3	]	]	PUNCT
admet-831	167	4	.	.	PUNCT
admet-831	168	1	predictions	prediction	NOUN
admet-831	168	2	for	for	ADP
admet-831	168	3	protein	protein	NOUN
admet-831	168	4	engineering	engineering	NOUN
admet-831	168	5	protein	protein	NOUN
admet-831	168	6	properties	property	NOUN
admet-831	168	7	have	have	VERB
admet-831	168	8	complex	complex	ADJ
admet-831	168	9	relations	relation	NOUN
admet-831	168	10	.	.	PUNCT
admet-831	169	1	several	several	ADJ
admet-831	169	2	approaches	approach	NOUN
admet-831	169	3	have	have	AUX
admet-831	169	4	been	be	AUX
admet-831	169	5	tried	try	VERB
admet-831	169	6	to	to	PART
admet-831	169	7	improve	improve	VERB
admet-831	169	8	solubility	solubility	NOUN
admet-831	169	9	or	or	CCONJ
admet-831	169	10	prevent	prevent	VERB
admet-831	169	11	aggregation	aggregation	NOUN
admet-831	169	12	.	.	PUNCT
admet-831	170	1	electrostatic	electrostatic	ADJ
admet-831	170	2	interactions	interaction	NOUN
admet-831	170	3	have	have	AUX
admet-831	170	4	been	be	AUX
admet-831	170	5	a	a	DET
admet-831	170	6	starting	starting	NOUN
admet-831	170	7	point	point	NOUN
admet-831	170	8	for	for	ADP
admet-831	170	9	one	one	NUM
admet-831	170	10	approach	approach	NOUN
admet-831	170	11	[	[	X
admet-831	170	12	51	51	NUM
admet-831	170	13	]	]	PUNCT
admet-831	170	14	,	,	PUNCT
admet-831	170	15	stability	stability	NOUN
admet-831	170	16	and	and	CCONJ
admet-831	170	17	aggregation	aggregation	NOUN
admet-831	170	18	for	for	ADP
admet-831	170	19	another	another	PRON
admet-831	170	20	[	[	X
admet-831	170	21	52	52	NUM
admet-831	170	22	]	]	PUNCT
admet-831	170	23	,	,	PUNCT
admet-831	170	24	and	and	CCONJ
admet-831	170	25	surface	surface	NOUN
admet-831	170	26	patches	patch	NOUN
admet-831	170	27	to	to	PART
admet-831	170	28	avoid	avoid	VERB
admet-831	170	29	aggregation	aggregation	NOUN
admet-831	170	30	for	for	ADP
admet-831	170	31	a	a	DET
admet-831	170	32	third	third	ADJ
admet-831	170	33	one	one	NUM
admet-831	170	34	[	[	X
admet-831	170	35	53	53	NUM
admet-831	170	36	]	]	PUNCT
admet-831	170	37	.	.	PUNCT
admet-831	171	1	solubis	solubis	PROPN
admet-831	171	2	tries	try	VERB
admet-831	171	3	to	to	PART
admet-831	171	4	reduce	reduce	VERB
admet-831	171	5	aggregation	aggregation	NOUN
admet-831	171	6	propensity	propensity	NOUN
admet-831	171	7	[	[	X
admet-831	171	8	48	48	NUM
admet-831	171	9	]	]	PUNCT
admet-831	171	10	.	.	PUNCT
admet-831	172	1	structural	structural	ADJ
admet-831	172	2	changes	change	NOUN
admet-831	172	3	designed	design	VERB
admet-831	172	4	by	by	ADP
admet-831	172	5	four	four	NUM
admet-831	172	6	tools	tool	NOUN
admet-831	172	7	have	have	AUX
admet-831	172	8	been	be	AUX
admet-831	172	9	reviewed	review	VERB
admet-831	172	10	in	in	ADP
admet-831	172	11	relation	relation	NOUN
admet-831	172	12	to	to	ADP
admet-831	172	13	structure	structure	NOUN
admet-831	172	14	-	-	PUNCT
admet-831	172	15	based	base	VERB
admet-831	172	16	predictions	prediction	NOUN
admet-831	172	17	[	[	X
admet-831	172	18	54	54	NUM
admet-831	172	19	]	]	PUNCT
admet-831	172	20	.	.	PUNCT
admet-831	173	1	the	the	DET
admet-831	173	2	discussed	discuss	VERB
admet-831	173	3	tools	tool	NOUN
admet-831	173	4	included	include	VERB
admet-831	173	5	aggrescan3d	aggrescan3d	PROPN
admet-831	173	6	,	,	PUNCT
admet-831	173	7	camsol	camsol	PROPN
admet-831	173	8	,	,	PUNCT
admet-831	173	9	spatial	spatial	ADJ
admet-831	173	10	aggregation	aggregation	NOUN
admet-831	173	11	propensity	propensity	NOUN
admet-831	173	12	(	(	PUNCT
admet-831	173	13	sap	sap	PROPN
admet-831	173	14	)	)	PUNCT
admet-831	173	15	and	and	CCONJ
admet-831	173	16	solubis	solubi	NOUN
admet-831	173	17	.	.	PUNCT
admet-831	174	1	sap	sap	PROPN
admet-831	174	2	was	be	AUX
admet-831	174	3	a	a	DET
admet-831	174	4	proposal	proposal	NOUN
admet-831	174	5	to	to	PART
admet-831	174	6	apply	apply	VERB
admet-831	174	7	molecular	molecular	ADJ
admet-831	174	8	dynamics	dynamic	NOUN
admet-831	174	9	simulations	simulation	NOUN
admet-831	174	10	,	,	PUNCT
admet-831	174	11	not	not	PART
admet-831	174	12	an	an	DET
admet-831	174	13	implemented	implement	VERB
admet-831	174	14	tool	tool	NOUN
admet-831	174	15	[	[	X
admet-831	174	16	55	55	NUM
admet-831	174	17	]	]	PUNCT
admet-831	174	18	.	.	PUNCT
admet-831	175	1	systematic	systematic	ADJ
admet-831	175	2	performance	performance	NOUN
admet-831	175	3	assessments	assessment	NOUN
admet-831	175	4	have	have	AUX
admet-831	175	5	not	not	PART
admet-831	175	6	been	be	AUX
admet-831	175	7	made	make	VERB
admet-831	175	8	to	to	ADP
admet-831	175	9	these	these	DET
admet-831	175	10	methods	method	NOUN
admet-831	175	11	.	.	PUNCT
admet-831	176	1	massively	massively	ADV
admet-831	176	2	parallel	parallel	ADJ
admet-831	176	3	reporter	reporter	NOUN
admet-831	176	4	assay	assay	NOUN
admet-831	176	5	(	(	PUNCT
admet-831	176	6	mpra	mpra	PROPN
admet-831	176	7	)	)	PUNCT
admet-831	176	8	of	of	ADP
admet-831	176	9	two	two	NUM
admet-831	176	10	proteins	protein	NOUN
admet-831	176	11	,	,	PUNCT
admet-831	176	12	tem-1	tem-1	X
admet-831	176	13	β	β	NOUN
admet-831	176	14	-	-	NOUN
admet-831	176	15	lactamase	lactamase	ADJ
admet-831	176	16	,	,	PUNCT
admet-831	176	17	a	a	DET
admet-831	176	18	common	common	ADJ
admet-831	176	19	antibiotic	antibiotic	ADJ
admet-831	176	20	resistance	resistance	NOUN
admet-831	176	21	protein	protein	NOUN
admet-831	176	22	in	in	ADP
admet-831	176	23	gram	gram	NOUN
admet-831	176	24	positive	positive	ADJ
admet-831	176	25	bacteria	bacteria	NOUN
admet-831	176	26	,	,	PUNCT
admet-831	176	27	and	and	CCONJ
admet-831	176	28	e.	e.	PROPN
admet-831	176	29	coli	coli	PROPN
admet-831	176	30	levoglucosan	levoglucosan	PROPN
admet-831	176	31	kinase	kinase	PROPN
admet-831	176	32	,	,	PUNCT
admet-831	176	33	indicated	indicate	VERB
admet-831	176	34	trade	trade	NOUN
admet-831	176	35	-	-	PUNCT
admet-831	176	36	offs	off	NOUN
admet-831	176	37	between	between	ADP
admet-831	176	38	fitness	fitness	NOUN
admet-831	176	39	and	and	CCONJ
admet-831	176	40	solubility	solubility	NOUN
admet-831	176	41	[	[	X
admet-831	176	42	56	56	NUM
admet-831	176	43	]	]	PUNCT
admet-831	176	44	.	.	PUNCT
admet-831	177	1	solubility	solubility	NOUN
admet-831	177	2	in	in	ADP
admet-831	177	3	this	this	DET
admet-831	177	4	paper	paper	NOUN
admet-831	177	5	was	be	AUX
admet-831	177	6	defined	define	VERB
admet-831	177	7	as	as	ADP
admet-831	177	8	properly	properly	ADV
admet-831	177	9	folded	fold	VERB
admet-831	177	10	protein	protein	NOUN
admet-831	177	11	.	.	PUNCT
admet-831	178	1	they	they	PRON
admet-831	178	2	used	use	VERB
admet-831	178	3	two	two	NUM
admet-831	178	4	analysis	analysis	NOUN
admet-831	178	5	methods	method	NOUN
admet-831	178	6	,	,	PUNCT
admet-831	178	7	which	which	PRON
admet-831	178	8	revealed	reveal	VERB
admet-831	178	9	whether	whether	SCONJ
admet-831	178	10	the	the	DET
admet-831	178	11	protein	protein	NOUN
admet-831	178	12	was	be	AUX
admet-831	178	13	folded	fold	VERB
admet-831	178	14	.	.	PUNCT
admet-831	179	1	in	in	ADP
admet-831	179	2	yeast	yeast	NOUN
admet-831	179	3	surface	surface	NOUN
admet-831	179	4	display	display	NOUN
admet-831	179	5	screen	screen	NOUN
admet-831	179	6	the	the	DET
admet-831	179	7	investigated	investigate	VERB
admet-831	179	8	protein	protein	NOUN
admet-831	179	9	had	have	VERB
admet-831	179	10	to	to	PART
admet-831	179	11	be	be	AUX
admet-831	179	12	folded	fold	VERB
admet-831	179	13	otherwise	otherwise	ADV
admet-831	179	14	the	the	DET
admet-831	179	15	fusion	fusion	NOUN
admet-831	179	16	protein	protein	NOUN
admet-831	179	17	was	be	AUX
admet-831	179	18	degraded	degrade	VERB
admet-831	179	19	.	.	PUNCT
admet-831	180	1	in	in	ADP
admet-831	180	2	twin	twin	ADJ
admet-831	180	3	-	-	PUNCT
admet-831	180	4	arginine	arginine	NOUN
admet-831	180	5	translocation	translocation	NOUN
admet-831	180	6	-	-	PUNCT
admet-831	180	7	selective	selective	ADJ
admet-831	180	8	export	export	NOUN
admet-831	180	9	the	the	DET
admet-831	180	10	protein	protein	NOUN
admet-831	180	11	was	be	AUX
admet-831	180	12	exported	export	VERB
admet-831	180	13	to	to	ADP
admet-831	180	14	bacterial	bacterial	ADJ
admet-831	180	15	periplasm	periplasm	NOUN
admet-831	180	16	only	only	ADV
admet-831	180	17	if	if	SCONJ
admet-831	180	18	correctly	correctly	ADV
admet-831	180	19	folded	fold	VERB
admet-831	180	20	.	.	PUNCT
admet-831	181	1	they	they	PRON
admet-831	181	2	generated	generate	VERB
admet-831	181	3	>	>	PUNCT
admet-831	181	4	93	93	NUM
admet-831	181	5	%	%	NOUN
admet-831	181	6	of	of	ADP
admet-831	181	7	all	all	DET
admet-831	181	8	possible	possible	ADJ
admet-831	181	9	single	single	ADJ
admet-831	181	10	amino	amino	NOUN
admet-831	181	11	acid	acid	NOUN
admet-831	181	12	variants	variant	NOUN
admet-831	181	13	in	in	ADP
admet-831	181	14	the	the	DET
admet-831	181	15	two	two	NUM
admet-831	181	16	proteins	protein	NOUN
admet-831	181	17	.	.	PUNCT
admet-831	182	1	solubility	solubility	NOUN
admet-831	182	2	increasing	increase	VERB
admet-831	182	3	variants	variant	NOUN
admet-831	182	4	were	be	AUX
admet-831	182	5	rare	rare	ADJ
admet-831	182	6	,	,	PUNCT
admet-831	182	7	only	only	ADV
admet-831	182	8	4	4	NUM
admet-831	182	9	to	to	PART
admet-831	182	10	5	5	NUM
admet-831	182	11	%	%	NOUN
admet-831	182	12	had	have	VERB
admet-831	182	13	this	this	DET
admet-831	182	14	effect	effect	NOUN
admet-831	182	15	.	.	PUNCT
admet-831	183	1	many	many	ADJ
admet-831	183	2	solubility	solubility	NOUN
admet-831	183	3	increasing	increase	VERB
admet-831	183	4	variants	variant	NOUN
admet-831	183	5	affected	affect	VERB
admet-831	183	6	also	also	ADV
admet-831	183	7	some	some	DET
admet-831	183	8	other	other	ADJ
admet-831	183	9	property	property	NOUN
admet-831	183	10	.	.	PUNCT
admet-831	184	1	comparisons	comparison	NOUN
admet-831	184	2	to	to	ADP
admet-831	184	3	fitness	fitness	NOUN
admet-831	184	4	increasing	increase	VERB
admet-831	184	5	variants	variant	NOUN
admet-831	184	6	revealed	reveal	VERB
admet-831	184	7	that	that	SCONJ
admet-831	184	8	these	these	DET
admet-831	184	9	two	two	NUM
admet-831	184	10	features	feature	NOUN
admet-831	184	11	co	co	VERB
admet-831	184	12	-	-	VERB
admet-831	184	13	occurred	occur	VERB
admet-831	184	14	very	very	ADV
admet-831	184	15	rarely	rarely	ADV
admet-831	184	16	and	and	CCONJ
admet-831	184	17	there	there	PRON
admet-831	184	18	were	be	VERB
admet-831	184	19	trade	trade	NOUN
admet-831	184	20	-	-	PUNCT
admet-831	184	21	offs	off	NOUN
admet-831	184	22	between	between	ADP
admet-831	184	23	them	they	PRON
admet-831	184	24	.	.	PUNCT
admet-831	185	1	conclusions	conclusion	NOUN
admet-831	185	2	computational	computational	ADJ
admet-831	185	3	methods	method	NOUN
admet-831	185	4	available	available	ADJ
admet-831	185	5	for	for	ADP
admet-831	185	6	the	the	DET
admet-831	185	7	prediction	prediction	NOUN
admet-831	185	8	of	of	ADP
admet-831	185	9	protein	protein	NOUN
admet-831	185	10	solubility	solubility	NOUN
admet-831	185	11	and	and	CCONJ
admet-831	185	12	aggregation	aggregation	NOUN
admet-831	185	13	were	be	AUX
admet-831	185	14	discussed	discuss	VERB
admet-831	185	15	along	along	ADP
admet-831	185	16	with	with	ADP
admet-831	185	17	tools	tool	NOUN
admet-831	185	18	for	for	ADP
admet-831	185	19	engineering	engineering	NOUN
admet-831	185	20	solubility	solubility	NOUN
admet-831	185	21	or	or	CCONJ
admet-831	185	22	aggregation	aggregation	NOUN
admet-831	185	23	by	by	ADP
admet-831	185	24	introducing	introduce	VERB
admet-831	185	25	amino	amino	NOUN
admet-831	185	26	acid	acid	NOUN
admet-831	185	27	substitutions	substitution	NOUN
admet-831	185	28	.	.	PUNCT
admet-831	186	1	many	many	ADJ
admet-831	186	2	features	feature	NOUN
admet-831	186	3	and	and	CCONJ
admet-831	186	4	different	different	ADJ
admet-831	186	5	algorithms	algorithm	NOUN
admet-831	186	6	have	have	AUX
admet-831	186	7	been	be	AUX
admet-831	186	8	applied	apply	VERB
admet-831	186	9	to	to	ADP
admet-831	186	10	the	the	DET
admet-831	186	11	available	available	ADJ
admet-831	186	12	solutions	solution	NOUN
admet-831	186	13	.	.	PUNCT
admet-831	187	1	although	although	SCONJ
admet-831	187	2	systematic	systematic	ADJ
admet-831	187	3	performance	performance	NOUN
admet-831	187	4	assessments	assessment	NOUN
admet-831	187	5	have	have	AUX
admet-831	187	6	not	not	PART
admet-831	187	7	been	be	AUX
admet-831	187	8	performed	perform	VERB
admet-831	187	9	,	,	PUNCT
admet-831	187	10	it	it	PRON
admet-831	187	11	is	be	AUX
admet-831	187	12	evident	evident	ADJ
admet-831	187	13	that	that	SCONJ
admet-831	187	14	the	the	DET
admet-831	187	15	methods	method	NOUN
admet-831	187	16	have	have	VERB
admet-831	187	17	widely	widely	ADV
admet-831	187	18	varying	vary	VERB
admet-831	187	19	performances	performance	NOUN
admet-831	187	20	.	.	PUNCT
admet-831	188	1	solubility	solubility	NOUN
admet-831	188	2	and	and	CCONJ
admet-831	188	3	avoidance	avoidance	NOUN
admet-831	188	4	of	of	ADP
admet-831	188	5	aggregation	aggregation	NOUN
admet-831	188	6	are	be	AUX
admet-831	188	7	crucial	crucial	ADJ
admet-831	188	8	properties	property	NOUN
admet-831	188	9	for	for	ADP
admet-831	188	10	any	any	DET
admet-831	188	11	protein	protein	NOUN
admet-831	188	12	to	to	PART
admet-831	188	13	be	be	AUX
admet-831	188	14	used	use	VERB
admet-831	188	15	for	for	ADP
admet-831	188	16	diagnosis	diagnosis	NOUN
admet-831	188	17	or	or	CCONJ
admet-831	188	18	therapy	therapy	NOUN
admet-831	188	19	.	.	PUNCT
admet-831	189	1	admet	admet	PROPN
admet-831	189	2	&	&	CCONJ
admet-831	189	3	dmpk	dmpk	PROPN
admet-831	189	4	8(4	8(4	NOUN
admet-831	189	5	)	)	PUNCT
admet-831	189	6	(	(	PUNCT
admet-831	189	7	2020	2020	NUM
admet-831	189	8	)	)	PUNCT
admet-831	189	9	391	391	NUM
admet-831	189	10	-	-	SYM
admet-831	189	11	399	399	NUM
admet-831	189	12	solubility	solubility	NOUN
admet-831	189	13	of	of	ADP
admet-831	189	14	proteins	protein	NOUN
admet-831	189	15	doi	doi	NOUN
admet-831	189	16	:	:	PUNCT
admet-831	189	17	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	NOUN
admet-831	189	18	397	397	NUM
admet-831	189	19	acknowledgements	acknowledgement	NOUN
admet-831	189	20	:	:	PUNCT
admet-831	189	21	financial	financial	ADJ
admet-831	189	22	support	support	NOUN
admet-831	189	23	from	from	ADP
admet-831	189	24	vetenskapsrådet	vetenskapsrådet	NOUN
admet-831	189	25	,	,	PUNCT
admet-831	189	26	swedish	swedish	ADJ
admet-831	189	27	cancer	cancer	NOUN
admet-831	189	28	society	society	PROPN
admet-831	189	29	and	and	CCONJ
admet-831	189	30	alfred	alfred	PROPN
admet-831	189	31	österlunds	österlund	NOUN
admet-831	189	32	stiftelse	stiftelse	PROPN
admet-831	189	33	is	be	AUX
admet-831	189	34	gratefully	gratefully	ADV
admet-831	189	35	acknowledged	acknowledge	VERB
admet-831	189	36	.	.	PUNCT
admet-831	190	1	conflict	conflict	NOUN
admet-831	190	2	of	of	ADP
admet-831	190	3	interest	interest	NOUN
admet-831	190	4	:	:	PUNCT
admet-831	190	5	none	none	NOUN
admet-831	190	6	.	.	PUNCT
admet-831	191	1	references	reference	NOUN
admet-831	191	2	[	[	X
admet-831	191	3	1	1	NUM
admet-831	191	4	]	]	X
admet-831	191	5	g.	g.	PROPN
admet-831	191	6	vecchi	vecchi	PROPN
admet-831	191	7	,	,	PUNCT
admet-831	191	8	p.	p.	PROPN
admet-831	191	9	sormanni	sormanni	PROPN
admet-831	191	10	,	,	PUNCT
admet-831	191	11	b.	b.	PROPN
admet-831	191	12	mannini	mannini	PROPN
admet-831	191	13	,	,	PUNCT
admet-831	191	14	a.	a.	PROPN
admet-831	191	15	vandelli	vandelli	PROPN
admet-831	191	16	,	,	PUNCT
admet-831	191	17	g.g	g.g	PROPN
admet-831	191	18	.	.	PROPN
admet-831	191	19	tartaglia	tartaglia	PROPN
admet-831	191	20	,	,	PUNCT
admet-831	191	21	c.m	c.m	PROPN
admet-831	191	22	.	.	PROPN
admet-831	191	23	dobson	dobson	PROPN
admet-831	191	24	,	,	PUNCT
admet-831	191	25	f.u	f.u	PROPN
admet-831	191	26	.	.	PROPN
admet-831	191	27	hartl	hartl	NOUN
admet-831	191	28	,	,	PUNCT
admet-831	191	29	m.	m.	NOUN
admet-831	191	30	vendruscolo	vendruscolo	NOUN
admet-831	191	31	.	.	PUNCT
admet-831	192	1	proteome	proteome	NOUN
admet-831	192	2	-	-	PUNCT
admet-831	192	3	wide	wide	ADJ
admet-831	192	4	observation	observation	NOUN
admet-831	192	5	of	of	ADP
admet-831	192	6	the	the	DET
admet-831	192	7	phenomenon	phenomenon	NOUN
admet-831	192	8	of	of	ADP
admet-831	192	9	life	life	NOUN
admet-831	192	10	on	on	ADP
admet-831	192	11	the	the	DET
admet-831	192	12	edge	edge	NOUN
admet-831	192	13	of	of	ADP
admet-831	192	14	solubility	solubility	NOUN
admet-831	192	15	.	.	PUNCT
admet-831	193	1	proc	proc	PROPN
admet-831	193	2	.	.	PUNCT
admet-831	194	1	natl	natl	PROPN
admet-831	194	2	.	.	PUNCT
admet-831	195	1	acad	acad	PROPN
admet-831	195	2	.	.	PUNCT
admet-831	196	1	sci	sci	PROPN
admet-831	196	2	.	.	PUNCT
admet-831	196	3	u.	u.	PROPN
admet-831	196	4	s.	s.	PROPN
admet-831	196	5	a.	a.	PROPN
admet-831	196	6	117	117	NUM
admet-831	196	7	(	(	PUNCT
admet-831	196	8	2020	2020	NUM
admet-831	196	9	)	)	PUNCT
admet-831	196	10	1015	1015	NUM
admet-831	196	11	-	-	SYM
admet-831	196	12	1020	1020	NUM
admet-831	196	13	.	.	PUNCT
admet-831	197	1	[	[	X
admet-831	197	2	2	2	X
admet-831	197	3	]	]	PUNCT
admet-831	197	4	t.	t.	PROPN
admet-831	197	5	arakawa	arakawa	PROPN
admet-831	197	6	,	,	PUNCT
admet-831	197	7	s.n	s.n	PROPN
admet-831	197	8	.	.	PROPN
admet-831	197	9	timasheff	timasheff	PROPN
admet-831	197	10	.	.	PUNCT
admet-831	198	1	theory	theory	NOUN
admet-831	198	2	of	of	ADP
admet-831	198	3	protein	protein	NOUN
admet-831	198	4	solubility	solubility	NOUN
admet-831	198	5	.	.	PUNCT
admet-831	199	1	methods	method	NOUN
admet-831	199	2	enzymol	enzymol	PROPN
admet-831	199	3	.	.	PUNCT
admet-831	200	1	114	114	NUM
admet-831	200	2	(	(	PUNCT
admet-831	200	3	1985	1985	NUM
admet-831	200	4	)	)	PUNCT
admet-831	200	5	49	49	NUM
admet-831	200	6	-	-	SYM
admet-831	200	7	77	77	NUM
admet-831	200	8	.	.	PUNCT
admet-831	201	1	[	[	X
admet-831	201	2	3	3	X
admet-831	201	3	]	]	X
admet-831	201	4	p.	p.	NOUN
admet-831	201	5	garidel	garidel	NOUN
admet-831	201	6	.	.	PUNCT
admet-831	202	1	protein	protein	NOUN
admet-831	202	2	solubility	solubility	NOUN
admet-831	202	3	from	from	ADP
admet-831	202	4	biochemical	biochemical	ADJ
admet-831	202	5	,	,	PUNCT
admet-831	202	6	physicochmical	physicochmical	ADJ
admet-831	202	7	and	and	CCONJ
admet-831	202	8	colloidal	colloidal	NOUN
admet-831	202	9	perspective	perspective	NOUN
admet-831	202	10	.	.	PUNCT
admet-831	203	1	am	be	AUX
admet-831	203	2	.	.	PUNCT
admet-831	204	1	pharm	pharm	PROPN
admet-831	204	2	.	.	PUNCT
admet-831	205	1	rev	rev	PROPN
admet-831	205	2	.	.	PROPN
admet-831	206	1	december	december	PROPN
admet-831	206	2	13	13	NUM
admet-831	206	3	(	(	PUNCT
admet-831	206	4	2013	2013	NUM
admet-831	206	5	)	)	PUNCT
admet-831	206	6	.	.	PUNCT
admet-831	207	1	[	[	X
admet-831	207	2	4	4	X
admet-831	207	3	]	]	X
admet-831	207	4	y.	y.	PROPN
admet-831	207	5	yang	yang	PROPN
admet-831	207	6	,	,	PUNCT
admet-831	207	7	a.	a.	NOUN
admet-831	207	8	niroula	niroula	PROPN
admet-831	207	9	,	,	PUNCT
admet-831	207	10	b.	b.	PROPN
admet-831	207	11	shen	shen	PROPN
admet-831	207	12	,	,	PUNCT
admet-831	207	13	m.	m.	PROPN
admet-831	207	14	vihinen	vihinen	PROPN
admet-831	207	15	.	.	PUNCT
admet-831	208	1	pon	pon	PROPN
admet-831	208	2	-	-	PUNCT
admet-831	208	3	sol	sol	NOUN
admet-831	208	4	:	:	PUNCT
admet-831	208	5	prediction	prediction	NOUN
admet-831	208	6	of	of	ADP
admet-831	208	7	effects	effect	NOUN
admet-831	208	8	of	of	ADP
admet-831	208	9	amino	amino	NOUN
admet-831	208	10	acid	acid	NOUN
admet-831	208	11	substitutions	substitution	NOUN
admet-831	208	12	on	on	ADP
admet-831	208	13	protein	protein	NOUN
admet-831	208	14	solubility	solubility	NOUN
admet-831	208	15	.	.	PUNCT
admet-831	209	1	bioinformatics	bioinformatic	NOUN
admet-831	209	2	32	32	NUM
admet-831	209	3	(	(	PUNCT
admet-831	209	4	2016	2016	NUM
admet-831	209	5	)	)	PUNCT
admet-831	209	6	2032	2032	NUM
admet-831	209	7	-	-	SYM
admet-831	209	8	2034	2034	NUM
admet-831	209	9	.	.	PUNCT
admet-831	210	1	[	[	X
admet-831	210	2	5	5	X
admet-831	210	3	]	]	PUNCT
admet-831	210	4	f.	f.	PROPN
admet-831	210	5	chiti	chiti	PROPN
admet-831	210	6	,	,	PUNCT
admet-831	210	7	c.m	c.m	PROPN
admet-831	210	8	.	.	PROPN
admet-831	210	9	dobson	dobson	PROPN
admet-831	210	10	.	.	PUNCT
admet-831	211	1	protein	protein	NOUN
admet-831	211	2	misfolding	misfolding	NOUN
admet-831	211	3	,	,	PUNCT
admet-831	211	4	amyloid	amyloid	NOUN
admet-831	211	5	formation	formation	NOUN
admet-831	211	6	,	,	PUNCT
admet-831	211	7	and	and	CCONJ
admet-831	211	8	human	human	ADJ
admet-831	211	9	disease	disease	NOUN
admet-831	211	10	:	:	PUNCT
admet-831	211	11	a	a	DET
admet-831	211	12	summary	summary	NOUN
admet-831	211	13	of	of	ADP
admet-831	211	14	progress	progress	NOUN
admet-831	211	15	over	over	ADP
admet-831	211	16	the	the	DET
admet-831	211	17	last	last	ADJ
admet-831	211	18	decade	decade	NOUN
admet-831	211	19	.	.	PUNCT
admet-831	212	1	annu	annu	NOUN
admet-831	212	2	.	.	PUNCT
admet-831	213	1	rev	rev	PROPN
admet-831	213	2	.	.	PROPN
admet-831	213	3	biochem	biochem	PROPN
admet-831	213	4	.	.	PUNCT
admet-831	214	1	86	86	NUM
admet-831	214	2	(	(	PUNCT
admet-831	214	3	2017	2017	NUM
admet-831	214	4	)	)	PUNCT
admet-831	214	5	27	27	NUM
admet-831	214	6	-	-	SYM
admet-831	214	7	68	68	NUM
admet-831	214	8	.	.	PUNCT
admet-831	215	1	[	[	X
admet-831	215	2	6	6	NUM
admet-831	215	3	]	]	SYM
admet-831	215	4	z.r	z.r	PROPN
admet-831	215	5	.	.	PROPN
admet-831	215	6	crook	crook	PROPN
admet-831	215	7	,	,	PUNCT
admet-831	215	8	n.w	n.w	PROPN
admet-831	215	9	.	.	PROPN
admet-831	215	10	nairn	nairn	PROPN
admet-831	215	11	,	,	PUNCT
admet-831	215	12	j.m	j.m	PROPN
admet-831	215	13	.	.	PROPN
admet-831	215	14	olson	olson	PROPN
admet-831	215	15	.	.	PUNCT
admet-831	216	1	miniproteins	miniprotein	NOUN
admet-831	216	2	as	as	ADP
admet-831	216	3	a	a	DET
admet-831	216	4	powerful	powerful	ADJ
admet-831	216	5	modality	modality	NOUN
admet-831	216	6	in	in	ADP
admet-831	216	7	drug	drug	NOUN
admet-831	216	8	development	development	NOUN
admet-831	216	9	.	.	PUNCT
admet-831	217	1	trends	trend	NOUN
admet-831	217	2	biochem	biochem	PROPN
admet-831	217	3	.	.	PUNCT
admet-831	218	1	sci	sci	PROPN
admet-831	218	2	.	.	PROPN
admet-831	219	1	45	45	NUM
admet-831	219	2	(	(	PUNCT
admet-831	219	3	2020	2020	NUM
admet-831	219	4	)	)	PUNCT
admet-831	219	5	332	332	NUM
admet-831	219	6	-	-	SYM
admet-831	219	7	346	346	NUM
admet-831	219	8	.	.	PUNCT
admet-831	220	1	[	[	X
admet-831	220	2	7	7	X
admet-831	220	3	]	]	PUNCT
admet-831	220	4	q.	q.	PROPN
admet-831	220	5	hou	hou	PROPN
admet-831	220	6	,	,	PUNCT
admet-831	220	7	r.	r.	PROPN
admet-831	220	8	bourgeas	bourgeas	PROPN
admet-831	220	9	,	,	PUNCT
admet-831	220	10	f.	f.	PROPN
admet-831	220	11	pucci	pucci	PROPN
admet-831	220	12	,	,	PUNCT
admet-831	220	13	m.	m.	NOUN
admet-831	220	14	rooman	rooman	NOUN
admet-831	220	15	.	.	PUNCT
admet-831	221	1	computational	computational	ADJ
admet-831	221	2	analysis	analysis	NOUN
admet-831	221	3	of	of	ADP
admet-831	221	4	the	the	DET
admet-831	221	5	amino	amino	NOUN
admet-831	221	6	acid	acid	NOUN
admet-831	221	7	interactions	interaction	NOUN
admet-831	221	8	that	that	PRON
admet-831	221	9	promote	promote	VERB
admet-831	221	10	or	or	CCONJ
admet-831	221	11	decrease	decrease	VERB
admet-831	221	12	protein	protein	NOUN
admet-831	221	13	solubility	solubility	NOUN
admet-831	221	14	.	.	PUNCT
admet-831	222	1	sci	sci	PROPN
admet-831	222	2	.	.	PROPN
admet-831	222	3	rep	rep	PROPN
admet-831	222	4	.	.	PROPN
admet-831	222	5	8	8	NUM
admet-831	222	6	(	(	PUNCT
admet-831	222	7	2018	2018	NUM
admet-831	222	8	)	)	PUNCT
admet-831	222	9	14661	14661	NUM
admet-831	222	10	.	.	PUNCT
admet-831	223	1	[	[	X
admet-831	223	2	8	8	NUM
admet-831	223	3	]	]	X
admet-831	223	4	b.k	b.k	PROPN
admet-831	223	5	.	.	NOUN
admet-831	223	6	bhandari	bhandari	PROPN
admet-831	223	7	,	,	PUNCT
admet-831	223	8	p.p	p.p	PROPN
admet-831	223	9	.	.	PROPN
admet-831	223	10	gardner	gardner	PROPN
admet-831	223	11	,	,	PUNCT
admet-831	223	12	c.s	c.s	PROPN
admet-831	223	13	.	.	PROPN
admet-831	223	14	lim	lim	PROPN
admet-831	223	15	.	.	PUNCT
admet-831	224	1	solubility	solubility	NOUN
admet-831	224	2	-	-	PUNCT
admet-831	224	3	weighted	weight	VERB
admet-831	224	4	index	index	NOUN
admet-831	224	5	:	:	PUNCT
admet-831	224	6	fast	fast	ADJ
admet-831	224	7	and	and	CCONJ
admet-831	224	8	accurate	accurate	ADJ
admet-831	224	9	prediction	prediction	NOUN
admet-831	224	10	of	of	ADP
admet-831	224	11	protein	protein	NOUN
admet-831	224	12	solubility	solubility	NOUN
admet-831	224	13	.	.	PUNCT
admet-831	225	1	(	(	PUNCT
admet-831	225	2	2020	2020	NUM
admet-831	225	3	)	)	PUNCT
admet-831	225	4	.	.	PUNCT
admet-831	226	1	https://doi.org/10.1093/bioinformatics/btaa578	https://doi.org/10.1093/bioinformatics/btaa578	X
admet-831	226	2	.	.	PUNCT
admet-831	227	1	[	[	X
admet-831	227	2	9	9	NUM
admet-831	227	3	]	]	X
admet-831	227	4	n.	n.	PROPN
admet-831	227	5	habibi	habibi	PROPN
admet-831	227	6	,	,	PUNCT
admet-831	227	7	s.z	s.z	PROPN
admet-831	227	8	.	.	PUNCT
admet-831	227	9	mohd	mohd	PROPN
admet-831	227	10	hashim	hashim	PROPN
admet-831	227	11	,	,	PUNCT
admet-831	227	12	a.	a.	PROPN
admet-831	227	13	norouzi	norouzi	PROPN
admet-831	227	14	,	,	PUNCT
admet-831	227	15	m.r	m.r	PROPN
admet-831	227	16	.	.	PROPN
admet-831	227	17	samian	samian	PROPN
admet-831	227	18	.	.	PUNCT
admet-831	228	1	a	a	DET
admet-831	228	2	review	review	NOUN
admet-831	228	3	of	of	ADP
admet-831	228	4	machine	machine	NOUN
admet-831	228	5	learning	learning	NOUN
admet-831	228	6	methods	method	NOUN
admet-831	228	7	to	to	PART
admet-831	228	8	predict	predict	VERB
admet-831	228	9	the	the	DET
admet-831	228	10	solubility	solubility	NOUN
admet-831	228	11	of	of	ADP
admet-831	228	12	overexpressed	overexpressed	ADJ
admet-831	228	13	recombinant	recombinant	ADJ
admet-831	228	14	proteins	protein	NOUN
admet-831	228	15	in	in	ADP
admet-831	228	16	escherichia	escherichia	NOUN
admet-831	228	17	coli	coli	NOUN
admet-831	228	18	.	.	PUNCT
admet-831	229	1	bmc	bmc	ADJ
admet-831	229	2	bioinformatics	bioinformatics	NOUN
admet-831	229	3	15	15	NUM
admet-831	229	4	(	(	PUNCT
admet-831	229	5	2014	2014	NUM
admet-831	229	6	)	)	PUNCT
admet-831	229	7	134	134	NUM
admet-831	229	8	.	.	PUNCT
admet-831	230	1	[	[	X
admet-831	230	2	10	10	NUM
admet-831	230	3	]	]	X
admet-831	230	4	f.	f.	PROPN
admet-831	230	5	agostini	agostini	PROPN
admet-831	230	6	,	,	PUNCT
admet-831	230	7	d.	d.	PROPN
admet-831	230	8	cirillo	cirillo	PROPN
admet-831	230	9	,	,	PUNCT
admet-831	230	10	c.m	c.m	PROPN
admet-831	230	11	.	.	PROPN
admet-831	230	12	livi	livi	PROPN
admet-831	230	13	,	,	PUNCT
admet-831	230	14	r.	r.	PROPN
admet-831	230	15	delli	delli	PROPN
admet-831	230	16	ponti	ponti	PROPN
admet-831	230	17	,	,	PUNCT
admet-831	230	18	g.g	g.g	PROPN
admet-831	230	19	.	.	PROPN
admet-831	230	20	tartaglia	tartaglia	PROPN
admet-831	230	21	.	.	PUNCT
admet-831	231	1	ccsol	ccsol	PROPN
admet-831	231	2	omics	omics	PROPN
admet-831	231	3	:	:	PUNCT
admet-831	231	4	a	a	DET
admet-831	231	5	webserver	webserver	NOUN
admet-831	231	6	for	for	ADP
admet-831	231	7	solubility	solubility	NOUN
admet-831	231	8	prediction	prediction	NOUN
admet-831	231	9	of	of	ADP
admet-831	231	10	endogenous	endogenous	ADJ
admet-831	231	11	and	and	CCONJ
admet-831	231	12	heterologous	heterologous	ADJ
admet-831	231	13	expression	expression	NOUN
admet-831	231	14	in	in	ADP
admet-831	231	15	escherichia	escherichia	NOUN
admet-831	231	16	coli	coli	NOUN
admet-831	231	17	.	.	PUNCT
admet-831	232	1	bioinformatics	bioinformatic	NOUN
admet-831	232	2	30	30	NUM
admet-831	232	3	(	(	PUNCT
admet-831	232	4	2014	2014	NUM
admet-831	232	5	)	)	PUNCT
admet-831	232	6	2975	2975	NUM
admet-831	232	7	-	-	SYM
admet-831	232	8	2977	2977	NUM
admet-831	232	9	.	.	PUNCT
admet-831	233	1	[	[	X
admet-831	233	2	11	11	NUM
admet-831	233	3	]	]	PUNCT
admet-831	233	4	s.	s.	PROPN
admet-831	233	5	khurana	khurana	PROPN
admet-831	233	6	,	,	PUNCT
admet-831	233	7	r.	r.	PROPN
admet-831	233	8	rawi	rawi	PROPN
admet-831	233	9	,	,	PUNCT
admet-831	233	10	k.	k.	PROPN
admet-831	233	11	kunji	kunji	X
admet-831	233	12	,	,	PUNCT
admet-831	233	13	g.y	g.y	PROPN
admet-831	233	14	.	.	PROPN
admet-831	233	15	chuang	chuang	PROPN
admet-831	233	16	,	,	PUNCT
admet-831	233	17	h.	h.	PROPN
admet-831	233	18	bensmail	bensmail	PROPN
admet-831	233	19	,	,	PUNCT
admet-831	233	20	r.	r.	PROPN
admet-831	233	21	mall	mall	PROPN
admet-831	233	22	.	.	PUNCT
admet-831	234	1	deepsol	deepsol	ADJ
admet-831	234	2	:	:	PUNCT
admet-831	234	3	a	a	DET
admet-831	234	4	deep	deep	ADJ
admet-831	234	5	learning	learning	NOUN
admet-831	234	6	framework	framework	NOUN
admet-831	234	7	for	for	ADP
admet-831	234	8	sequence	sequence	NOUN
admet-831	234	9	-	-	PUNCT
admet-831	234	10	based	base	VERB
admet-831	234	11	protein	protein	NOUN
admet-831	234	12	solubility	solubility	NOUN
admet-831	234	13	prediction	prediction	NOUN
admet-831	234	14	.	.	PUNCT
admet-831	235	1	bioinformatics	bioinformatic	NOUN
admet-831	235	2	34	34	NUM
admet-831	235	3	(	(	PUNCT
admet-831	235	4	2018	2018	NUM
admet-831	235	5	)	)	PUNCT
admet-831	235	6	2605	2605	NUM
admet-831	235	7	-	-	SYM
admet-831	235	8	2613	2613	NUM
admet-831	235	9	.	.	PUNCT
admet-831	236	1	[	[	X
admet-831	236	2	12	12	NUM
admet-831	236	3	]	]	X
admet-831	236	4	r.	r.	PROPN
admet-831	236	5	rawi	rawi	PROPN
admet-831	236	6	,	,	PUNCT
admet-831	236	7	r.	r.	PROPN
admet-831	236	8	mall	mall	PROPN
admet-831	236	9	,	,	PUNCT
admet-831	236	10	k.	k.	PROPN
admet-831	236	11	kunji	kunji	X
admet-831	236	12	,	,	PUNCT
admet-831	236	13	c.h	c.h	PROPN
admet-831	236	14	.	.	PROPN
admet-831	236	15	shen	shen	PROPN
admet-831	236	16	,	,	PUNCT
admet-831	236	17	p.d	p.d	PROPN
admet-831	236	18	.	.	PROPN
admet-831	236	19	kwong	kwong	PROPN
admet-831	236	20	,	,	PUNCT
admet-831	236	21	g.y	g.y	PROPN
admet-831	236	22	.	.	PUNCT
admet-831	236	23	chuang	chuang	PROPN
admet-831	236	24	.	.	PUNCT
admet-831	237	1	parsnip	parsnip	NOUN
admet-831	237	2	:	:	PUNCT
admet-831	237	3	sequence	sequence	NOUN
admet-831	237	4	-	-	PUNCT
admet-831	237	5	based	base	VERB
admet-831	237	6	protein	protein	NOUN
admet-831	237	7	solubility	solubility	NOUN
admet-831	237	8	prediction	prediction	NOUN
admet-831	237	9	using	use	VERB
admet-831	237	10	gradient	gradient	NOUN
admet-831	237	11	boosting	boost	VERB
admet-831	237	12	machine	machine	NOUN
admet-831	237	13	.	.	PUNCT
admet-831	238	1	bioinformatics	bioinformatic	NOUN
admet-831	238	2	34	34	NUM
admet-831	238	3	(	(	PUNCT
admet-831	238	4	2018	2018	NUM
admet-831	238	5	)	)	PUNCT
admet-831	238	6	1092	1092	NUM
admet-831	238	7	-	-	SYM
admet-831	238	8	1098	1098	NUM
admet-831	238	9	.	.	PUNCT
admet-831	239	1	[	[	X
admet-831	239	2	13	13	NUM
admet-831	239	3	]	]	PUNCT
admet-831	239	4	m.	m.	NOUN
admet-831	239	5	hebditch	hebditch	PROPN
admet-831	239	6	,	,	PUNCT
admet-831	239	7	m.a	m.a	PROPN
admet-831	239	8	.	.	PROPN
admet-831	239	9	carballo	carballo	PROPN
admet-831	239	10	-	-	PUNCT
admet-831	239	11	amador	amador	PROPN
admet-831	239	12	,	,	PUNCT
admet-831	239	13	s.	s.	PROPN
admet-831	239	14	charonis	charonis	PROPN
admet-831	239	15	,	,	PUNCT
admet-831	239	16	r.	r.	PROPN
admet-831	239	17	curtis	curtis	PROPN
admet-831	239	18	,	,	PUNCT
admet-831	239	19	j.	j.	PROPN
admet-831	239	20	warwicker	warwicker	PROPN
admet-831	239	21	.	.	PUNCT
admet-831	240	1	protein	protein	NOUN
admet-831	240	2	-	-	PUNCT
admet-831	240	3	sol	sol	NOUN
admet-831	240	4	:	:	PUNCT
admet-831	240	5	a	a	DET
admet-831	240	6	web	web	NOUN
admet-831	240	7	tool	tool	NOUN
admet-831	240	8	for	for	ADP
admet-831	240	9	predicting	predict	VERB
admet-831	240	10	protein	protein	NOUN
admet-831	240	11	solubility	solubility	NOUN
admet-831	240	12	from	from	ADP
admet-831	240	13	sequence	sequence	NOUN
admet-831	240	14	.	.	PUNCT
admet-831	241	1	bioinformatics	bioinformatic	NOUN
admet-831	241	2	33	33	NUM
admet-831	241	3	(	(	PUNCT
admet-831	241	4	2017	2017	NUM
admet-831	241	5	)	)	PUNCT
admet-831	241	6	3098	3098	NUM
admet-831	241	7	-	-	SYM
admet-831	241	8	3100	3100	NUM
admet-831	241	9	.	.	PUNCT
admet-831	242	1	[	[	X
admet-831	242	2	14	14	NUM
admet-831	242	3	]	]	X
admet-831	242	4	l.	l.	PROPN
admet-831	242	5	paladin	paladin	PROPN
admet-831	242	6	,	,	PUNCT
admet-831	242	7	d.	d.	PROPN
admet-831	242	8	piovesan	piovesan	NOUN
admet-831	242	9	,	,	PUNCT
admet-831	242	10	s.c.e	s.c.e	ADJ
admet-831	242	11	.	.	PUNCT
admet-831	242	12	tosatto	tosatto	NOUN
admet-831	242	13	.	.	PUNCT
admet-831	243	1	soda	soda	NOUN
admet-831	243	2	:	:	PUNCT
admet-831	243	3	prediction	prediction	NOUN
admet-831	243	4	of	of	ADP
admet-831	243	5	protein	protein	NOUN
admet-831	243	6	solubility	solubility	NOUN
admet-831	243	7	from	from	ADP
admet-831	243	8	disorder	disorder	NOUN
admet-831	243	9	and	and	CCONJ
admet-831	243	10	aggregation	aggregation	NOUN
admet-831	243	11	propensity	propensity	NOUN
admet-831	243	12	.	.	PUNCT
admet-831	244	1	nucleic	nucleic	ADJ
admet-831	244	2	acids	acid	NOUN
admet-831	244	3	res	re	NOUN
admet-831	244	4	.	.	PUNCT
admet-831	245	1	45	45	NUM
admet-831	245	2	(	(	PUNCT
admet-831	245	3	2017	2017	NUM
admet-831	245	4	)	)	PUNCT
admet-831	246	1	w236	w236	PROPN
admet-831	246	2	-	-	PUNCT
admet-831	246	3	w240	w240	PROPN
admet-831	246	4	.	.	PUNCT
admet-831	247	1	[	[	X
admet-831	247	2	15	15	NUM
admet-831	247	3	]	]	X
admet-831	247	4	q.	q.	PROPN
admet-831	247	5	hou	hou	PROPN
admet-831	247	6	,	,	PUNCT
admet-831	247	7	j.m	j.m	PROPN
admet-831	247	8	.	.	PROPN
admet-831	247	9	kwasigroch	kwasigroch	PROPN
admet-831	247	10	,	,	PUNCT
admet-831	247	11	m.	m.	NOUN
admet-831	247	12	rooman	rooman	PROPN
admet-831	247	13	,	,	PUNCT
admet-831	247	14	f.	f.	PROPN
admet-831	247	15	pucci	pucci	PROPN
admet-831	247	16	.	.	PUNCT
admet-831	248	1	solart	solart	NOUN
admet-831	248	2	:	:	PUNCT
admet-831	248	3	a	a	DET
admet-831	248	4	structure	structure	NOUN
admet-831	248	5	-	-	PUNCT
admet-831	248	6	based	base	VERB
admet-831	248	7	method	method	NOUN
admet-831	248	8	to	to	PART
admet-831	248	9	predict	predict	VERB
admet-831	248	10	protein	protein	NOUN
admet-831	248	11	solubility	solubility	NOUN
admet-831	248	12	and	and	CCONJ
admet-831	248	13	aggregation	aggregation	NOUN
admet-831	248	14	.	.	PUNCT
admet-831	249	1	bioinformatics	bioinformatic	NOUN
admet-831	249	2	36	36	NUM
admet-831	249	3	(	(	PUNCT
admet-831	249	4	2020	2020	NUM
admet-831	249	5	)	)	PUNCT
admet-831	249	6	1445	1445	NUM
admet-831	249	7	-	-	SYM
admet-831	249	8	1452	1452	NUM
admet-831	249	9	.	.	PUNCT
admet-831	250	1	[	[	X
admet-831	250	2	16	16	NUM
admet-831	250	3	]	]	X
admet-831	250	4	c.n	c.n	PROPN
admet-831	250	5	.	.	PROPN
admet-831	250	6	magnan	magnan	PROPN
admet-831	250	7	,	,	PUNCT
admet-831	250	8	a.	a.	PROPN
admet-831	250	9	randall	randall	PROPN
admet-831	250	10	,	,	PUNCT
admet-831	250	11	p.	p.	PROPN
admet-831	250	12	baldi	baldi	PROPN
admet-831	250	13	.	.	PUNCT
admet-831	251	1	solpro	solpro	ADJ
admet-831	251	2	:	:	PUNCT
admet-831	251	3	accurate	accurate	ADJ
admet-831	251	4	sequence	sequence	NOUN
admet-831	251	5	-	-	PUNCT
admet-831	251	6	based	base	VERB
admet-831	251	7	prediction	prediction	NOUN
admet-831	251	8	of	of	ADP
admet-831	251	9	protein	protein	NOUN
admet-831	251	10	solubility	solubility	NOUN
admet-831	251	11	.	.	PUNCT
admet-831	252	1	bioinformatics	bioinformatics	NOUN
admet-831	252	2	25	25	NUM
admet-831	252	3	(	(	PUNCT
admet-831	252	4	2009	2009	NUM
admet-831	252	5	)	)	PUNCT
admet-831	252	6	2200	2200	NUM
admet-831	252	7	-	-	SYM
admet-831	252	8	2207	2207	NUM
admet-831	252	9	.	.	PUNCT
admet-831	253	1	[	[	X
admet-831	253	2	17	17	NUM
admet-831	253	3	]	]	X
admet-831	253	4	m.j	m.j	PROPN
admet-831	253	5	.	.	PROPN
admet-831	253	6	gabanyi	gabanyi	PROPN
admet-831	253	7	,	,	PUNCT
admet-831	253	8	p.d	p.d	PROPN
admet-831	253	9	.	.	PROPN
admet-831	253	10	adams	adams	PROPN
admet-831	253	11	,	,	PUNCT
admet-831	253	12	k.	k.	PROPN
admet-831	253	13	arnold	arnold	PROPN
admet-831	253	14	,	,	PUNCT
admet-831	253	15	l.	l.	PROPN
admet-831	253	16	bordoli	bordoli	PROPN
admet-831	253	17	,	,	PUNCT
admet-831	253	18	l.g	l.g	PROPN
admet-831	253	19	.	.	PROPN
admet-831	253	20	carter	carter	PROPN
admet-831	253	21	,	,	PUNCT
admet-831	253	22	j.	j.	PROPN
admet-831	253	23	flippen	flippen	PROPN
admet-831	253	24	-	-	PUNCT
admet-831	253	25	andersen	andersen	PROPN
admet-831	253	26	,	,	PUNCT
admet-831	253	27	l.	l.	PROPN
admet-831	253	28	gifford	gifford	PROPN
admet-831	253	29	,	,	PUNCT
admet-831	253	30	j.	j.	PROPN
admet-831	253	31	haas	haas	PROPN
admet-831	253	32	,	,	PUNCT
admet-831	253	33	a.	a.	PROPN
admet-831	253	34	kouranov	kouranov	PROPN
admet-831	253	35	,	,	PUNCT
admet-831	253	36	w.a	w.a	PROPN
admet-831	253	37	.	.	PROPN
admet-831	253	38	mclaughlin	mclaughlin	PROPN
admet-831	253	39	,	,	PUNCT
admet-831	253	40	d.i	d.i	PROPN
admet-831	253	41	.	.	PROPN
admet-831	253	42	micallef	micallef	PROPN
admet-831	253	43	,	,	PUNCT
admet-831	253	44	w.	w.	PROPN
admet-831	253	45	minor	minor	PROPN
admet-831	253	46	,	,	PUNCT
admet-831	253	47	r.	r.	PROPN
admet-831	253	48	shah	shah	PROPN
admet-831	253	49	,	,	PUNCT
admet-831	253	50	t.	t.	NOUN
admet-831	253	51	schwede	schwede	PROPN
admet-831	253	52	,	,	PUNCT
admet-831	253	53	y.p	y.p	PROPN
admet-831	253	54	.	.	PROPN
admet-831	253	55	tao	tao	PROPN
admet-831	253	56	,	,	PUNCT
admet-831	253	57	j.d	j.d	PROPN
admet-831	253	58	.	.	PROPN
admet-831	253	59	westbrook	westbrook	PROPN
admet-831	253	60	,	,	PUNCT
admet-831	253	61	m.	m.	PROPN
admet-831	253	62	zimmerman	zimmerman	PROPN
admet-831	253	63	,	,	PUNCT
admet-831	253	64	h.m	h.m	PROPN
admet-831	253	65	.	.	PROPN
admet-831	253	66	berman	berman	PROPN
admet-831	253	67	.	.	PUNCT
admet-831	254	1	the	the	DET
admet-831	254	2	structural	structural	ADJ
admet-831	254	3	biology	biology	NOUN
admet-831	254	4	knowledgebase	knowledgebase	PROPN
admet-831	254	5	:	:	PUNCT
admet-831	254	6	a	a	DET
admet-831	254	7	portal	portal	NOUN
admet-831	254	8	to	to	ADP
admet-831	254	9	protein	protein	NOUN
admet-831	254	10	structures	structure	NOUN
admet-831	254	11	,	,	PUNCT
admet-831	254	12	sequences	sequence	NOUN
admet-831	254	13	,	,	PUNCT
admet-831	254	14	functions	function	NOUN
admet-831	254	15	,	,	PUNCT
admet-831	254	16	and	and	CCONJ
admet-831	254	17	methods	method	NOUN
admet-831	254	18	.	.	PUNCT
admet-831	255	1	j.	j.	PROPN
admet-831	255	2	struct	struct	PROPN
admet-831	255	3	.	.	PUNCT
admet-831	256	1	funct	funct	PROPN
admet-831	256	2	.	.	PUNCT
admet-831	257	1	genomics	genomic	NOUN
admet-831	257	2	12	12	NUM
admet-831	257	3	(	(	PUNCT
admet-831	257	4	2011	2011	NUM
admet-831	257	5	)	)	PUNCT
admet-831	257	6	45	45	NUM
admet-831	257	7	-	-	SYM
admet-831	257	8	54	54	NUM
admet-831	257	9	.	.	PUNCT
admet-831	258	1	[	[	X
admet-831	258	2	18	18	NUM
admet-831	258	3	]	]	PUNCT
admet-831	258	4	t.	t.	PROPN
admet-831	258	5	niwa	niwa	PROPN
admet-831	258	6	,	,	PUNCT
admet-831	258	7	b.w	b.w	PROPN
admet-831	258	8	.	.	PROPN
admet-831	258	9	ying	ying	PROPN
admet-831	258	10	,	,	PUNCT
admet-831	258	11	k.	k.	PROPN
admet-831	258	12	saito	saito	PROPN
admet-831	258	13	,	,	PUNCT
admet-831	258	14	w.	w.	PROPN
admet-831	258	15	jin	jin	PROPN
admet-831	258	16	,	,	PUNCT
admet-831	258	17	s.	s.	PROPN
admet-831	258	18	takada	takada	PROPN
admet-831	258	19	,	,	PUNCT
admet-831	258	20	t.	t.	PROPN
admet-831	258	21	ueda	ueda	PROPN
admet-831	258	22	,	,	PUNCT
admet-831	258	23	h.	h.	PROPN
admet-831	258	24	taguchi	taguchi	PROPN
admet-831	258	25	.	.	PUNCT
admet-831	259	1	bimodal	bimodal	NOUN
admet-831	259	2	protein	protein	NOUN
admet-831	259	3	solubility	solubility	NOUN
admet-831	259	4	distribution	distribution	NOUN
admet-831	259	5	revealed	reveal	VERB
admet-831	259	6	by	by	ADP
admet-831	259	7	an	an	DET
admet-831	259	8	aggregation	aggregation	NOUN
admet-831	259	9	analysis	analysis	NOUN
admet-831	259	10	of	of	ADP
admet-831	259	11	the	the	DET
admet-831	259	12	entire	entire	ADJ
admet-831	259	13	ensemble	ensemble	NOUN
admet-831	259	14	of	of	ADP
admet-831	259	15	escherichia	escherichia	NOUN
admet-831	259	16	coli	coli	NOUN
admet-831	259	17	proteins	protein	NOUN
admet-831	259	18	.	.	PUNCT
admet-831	260	1	proc	proc	NOUN
admet-831	260	2	.	.	PUNCT
admet-831	261	1	natl	natl	PROPN
admet-831	261	2	.	.	PUNCT
admet-831	262	1	acad	acad	PROPN
admet-831	262	2	.	.	PUNCT
admet-831	263	1	sci	sci	PROPN
admet-831	263	2	.	.	PUNCT
admet-831	263	3	u.	u.	PROPN
admet-831	263	4	s.	s.	PROPN
admet-831	263	5	a.	a.	PROPN
admet-831	263	6	106	106	NUM
admet-831	263	7	(	(	PUNCT
admet-831	263	8	2009	2009	NUM
admet-831	263	9	)	)	PUNCT
admet-831	263	10	4201	4201	NUM
admet-831	263	11	-	-	SYM
admet-831	263	12	4206	4206	NUM
admet-831	263	13	.	.	PUNCT
admet-831	263	14	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PROPN
admet-831	263	15	https://doi.org/10.1093/bioinformatics/btaa578	https://doi.org/10.1093/bioinformatics/btaa578	PROPN
admet-831	263	16	mauno	mauno	PROPN
admet-831	263	17	vihinen	vihinen	PROPN
admet-831	263	18	admet	admet	PROPN
admet-831	263	19	&	&	CCONJ
admet-831	263	20	dmpk	dmpk	PROPN
admet-831	263	21	8(4	8(4	NOUN
admet-831	263	22	)	)	PUNCT
admet-831	263	23	(	(	PUNCT
admet-831	263	24	2020	2020	NUM
admet-831	263	25	)	)	PUNCT
admet-831	263	26	391	391	NUM
admet-831	263	27	-	-	SYM
admet-831	263	28	399	399	NUM
admet-831	263	29	398	398	NUM
admet-831	263	30	[	[	X
admet-831	263	31	19	19	NUM
admet-831	263	32	]	]	X
admet-831	263	33	e.	e.	PROPN
admet-831	263	34	uemura	uemura	PROPN
admet-831	263	35	,	,	PUNCT
admet-831	263	36	t.	t.	PROPN
admet-831	263	37	niwa	niwa	PROPN
admet-831	263	38	,	,	PUNCT
admet-831	263	39	s.	s.	PROPN
admet-831	263	40	minami	minami	PROPN
admet-831	263	41	,	,	PUNCT
admet-831	263	42	k.	k.	PROPN
admet-831	263	43	takemoto	takemoto	PROPN
admet-831	263	44	,	,	PUNCT
admet-831	263	45	s.	s.	PROPN
admet-831	263	46	fukuchi	fukuchi	PROPN
admet-831	263	47	,	,	PUNCT
admet-831	263	48	k.	k.	PROPN
admet-831	263	49	machida	machida	PROPN
admet-831	263	50	,	,	PUNCT
admet-831	263	51	h.	h.	PROPN
admet-831	263	52	imataka	imataka	PROPN
admet-831	263	53	,	,	PUNCT
admet-831	263	54	t.	t.	PROPN
admet-831	263	55	ueda	ueda	PROPN
admet-831	263	56	,	,	PUNCT
admet-831	263	57	m.	m.	PROPN
admet-831	263	58	ota	ota	PROPN
admet-831	263	59	,	,	PUNCT
admet-831	263	60	h.	h.	PROPN
admet-831	263	61	taguchi	taguchi	PROPN
admet-831	263	62	.	.	PUNCT
admet-831	264	1	large	large	ADJ
admet-831	264	2	-	-	PUNCT
admet-831	264	3	scale	scale	NOUN
admet-831	264	4	aggregation	aggregation	NOUN
admet-831	264	5	analysis	analysis	NOUN
admet-831	264	6	of	of	ADP
admet-831	264	7	eukaryotic	eukaryotic	ADJ
admet-831	264	8	proteins	protein	NOUN
admet-831	264	9	reveals	reveal	VERB
admet-831	264	10	an	an	DET
admet-831	264	11	involvement	involvement	NOUN
admet-831	264	12	of	of	ADP
admet-831	264	13	intrinsically	intrinsically	ADV
admet-831	264	14	disordered	disordered	ADJ
admet-831	264	15	regions	region	NOUN
admet-831	264	16	in	in	ADP
admet-831	264	17	protein	protein	NOUN
admet-831	264	18	folding	folding	NOUN
admet-831	264	19	.	.	PUNCT
admet-831	265	1	sci	sci	PROPN
admet-831	265	2	.	.	PROPN
admet-831	265	3	rep	rep	PROPN
admet-831	265	4	.	.	PROPN
admet-831	265	5	8	8	NUM
admet-831	265	6	(	(	PUNCT
admet-831	265	7	2018	2018	NUM
admet-831	265	8	)	)	PUNCT
admet-831	265	9	678	678	NUM
admet-831	265	10	.	.	PUNCT
admet-831	266	1	[	[	X
admet-831	266	2	20	20	NUM
admet-831	266	3	]	]	PUNCT
admet-831	266	4	m.	m.	NOUN
admet-831	266	5	vihinen	vihinen	PROPN
admet-831	266	6	.	.	PUNCT
admet-831	267	1	how	how	SCONJ
admet-831	267	2	to	to	PART
admet-831	267	3	evaluate	evaluate	VERB
admet-831	267	4	performance	performance	NOUN
admet-831	267	5	of	of	ADP
admet-831	267	6	prediction	prediction	NOUN
admet-831	267	7	methods	method	NOUN
admet-831	267	8	?	?	PUNCT
admet-831	267	9	measures	measure	NOUN
admet-831	267	10	and	and	CCONJ
admet-831	267	11	their	their	PRON
admet-831	267	12	interpretation	interpretation	NOUN
admet-831	267	13	in	in	ADP
admet-831	267	14	variation	variation	NOUN
admet-831	267	15	effect	effect	NOUN
admet-831	267	16	analysis	analysis	NOUN
admet-831	267	17	.	.	PUNCT
admet-831	268	1	bmc	bmc	ADJ
admet-831	268	2	genomics	genomic	NOUN
admet-831	268	3	13	13	NUM
admet-831	268	4	suppl	suppl	ADJ
admet-831	268	5	4	4	NUM
admet-831	268	6	(	(	PUNCT
admet-831	268	7	2012	2012	NUM
admet-831	268	8	)	)	PUNCT
admet-831	268	9	s2	s2	NOUN
admet-831	268	10	.	.	PUNCT
admet-831	269	1	[	[	X
admet-831	269	2	21	21	NUM
admet-831	269	3	]	]	X
admet-831	269	4	m.	m.	NOUN
admet-831	269	5	vihinen	vihinen	PROPN
admet-831	269	6	.	.	PUNCT
admet-831	270	1	guidelines	guideline	NOUN
admet-831	270	2	for	for	ADP
admet-831	270	3	reporting	reporting	NOUN
admet-831	270	4	and	and	CCONJ
admet-831	270	5	using	use	VERB
admet-831	270	6	prediction	prediction	NOUN
admet-831	270	7	tools	tool	NOUN
admet-831	270	8	for	for	ADP
admet-831	270	9	genetic	genetic	ADJ
admet-831	270	10	variation	variation	NOUN
admet-831	270	11	analysis	analysis	NOUN
admet-831	270	12	.	.	PUNCT
admet-831	271	1	hum	hum	ADJ
admet-831	271	2	.	.	PUNCT
admet-831	272	1	mutat	mutat	ADJ
admet-831	272	2	.	.	PUNCT
admet-831	273	1	34	34	NUM
admet-831	273	2	(	(	PUNCT
admet-831	273	3	2013	2013	NUM
admet-831	273	4	)	)	PUNCT
admet-831	273	5	275	275	NUM
admet-831	273	6	-	-	SYM
admet-831	273	7	282	282	NUM
admet-831	273	8	.	.	PUNCT
admet-831	274	1	[	[	X
admet-831	274	2	22	22	NUM
admet-831	274	3	]	]	PUNCT
admet-831	274	4	p.	p.	NOUN
admet-831	274	5	smialowski	smialowski	NOUN
admet-831	274	6	,	,	PUNCT
admet-831	274	7	g.	g.	PROPN
admet-831	274	8	doose	doose	PROPN
admet-831	274	9	,	,	PUNCT
admet-831	274	10	p.	p.	NOUN
admet-831	274	11	torkler	torkler	NOUN
admet-831	274	12	,	,	PUNCT
admet-831	274	13	s.	s.	PROPN
admet-831	274	14	kaufmann	kaufmann	PROPN
admet-831	274	15	,	,	PUNCT
admet-831	274	16	d.	d.	PROPN
admet-831	274	17	frishman	frishman	PROPN
admet-831	274	18	.	.	PUNCT
admet-831	275	1	proso	proso	PROPN
admet-831	275	2	ii	ii	PROPN
admet-831	275	3	--	--	PUNCT
admet-831	275	4	a	a	DET
admet-831	275	5	new	new	ADJ
admet-831	275	6	method	method	NOUN
admet-831	275	7	for	for	ADP
admet-831	275	8	protein	protein	NOUN
admet-831	275	9	solubility	solubility	NOUN
admet-831	275	10	prediction	prediction	NOUN
admet-831	275	11	.	.	PUNCT
admet-831	276	1	febs	febs	PROPN
admet-831	276	2	j.	j.	PROPN
admet-831	276	3	279	279	NUM
admet-831	276	4	(	(	PUNCT
admet-831	276	5	2012	2012	NUM
admet-831	276	6	)	)	PUNCT
admet-831	276	7	2192	2192	NUM
admet-831	276	8	-	-	SYM
admet-831	276	9	2200	2200	NUM
admet-831	276	10	.	.	PUNCT
admet-831	277	1	[	[	X
admet-831	277	2	23	23	NUM
admet-831	277	3	]	]	X
admet-831	277	4	f.a	f.a	PROPN
admet-831	277	5	.	.	PROPN
admet-831	277	6	ghomi	ghomi	PROPN
admet-831	277	7	,	,	PUNCT
admet-831	277	8	t.	t.	PROPN
admet-831	277	9	kittilä	kittilä	PROPN
admet-831	277	10	,	,	PUNCT
admet-831	277	11	d.h	d.h	PROPN
admet-831	277	12	.	.	PROPN
admet-831	277	13	welner	welner	NOUN
admet-831	277	14	.	.	PUNCT
admet-831	278	1	a	a	DET
admet-831	278	2	benchmark	benchmark	NOUN
admet-831	278	3	of	of	ADP
admet-831	278	4	protein	protein	NOUN
admet-831	278	5	solubility	solubility	NOUN
admet-831	278	6	prediction	prediction	NOUN
admet-831	278	7	methods	method	NOUN
admet-831	278	8	on	on	ADP
admet-831	278	9	udpdependent	udpdependent	ADJ
admet-831	278	10	glycosyltransferases	glycosyltransferase	NOUN
admet-831	278	11	.	.	PUNCT
admet-831	279	1	(	(	PUNCT
admet-831	279	2	2020	2020	NUM
admet-831	279	3	)	)	PUNCT
admet-831	279	4	.	.	PUNCT
admet-831	280	1	doi	doi	NOUN
admet-831	280	2	:	:	PUNCT
admet-831	280	3	https://doi.org/10.1101/2020.02.28.962894	https://doi.org/10.1101/2020.02.28.962894	PROPN
admet-831	280	4	.	.	PUNCT
admet-831	281	1	[	[	X
admet-831	281	2	24	24	NUM
admet-831	281	3	]	]	SYM
admet-831	281	4	a.b	a.b	PROPN
admet-831	281	5	.	.	PROPN
admet-831	281	6	ahmed	ahmed	PROPN
admet-831	281	7	,	,	PUNCT
admet-831	281	8	a.v	a.v	PROPN
admet-831	281	9	.	.	PROPN
admet-831	281	10	kajava	kajava	PROPN
admet-831	281	11	.	.	PUNCT
admet-831	282	1	breaking	break	VERB
admet-831	282	2	the	the	DET
admet-831	282	3	amyloidogenicity	amyloidogenicity	NOUN
admet-831	282	4	code	code	NOUN
admet-831	282	5	:	:	PUNCT
admet-831	282	6	methods	method	NOUN
admet-831	282	7	to	to	PART
admet-831	282	8	predict	predict	VERB
admet-831	282	9	amyloids	amyloid	NOUN
admet-831	282	10	from	from	ADP
admet-831	282	11	amino	amino	NOUN
admet-831	282	12	acid	acid	NOUN
admet-831	282	13	sequence	sequence	NOUN
admet-831	282	14	.	.	PUNCT
admet-831	283	1	febs	febs	PROPN
admet-831	283	2	lett	lett	PROPN
admet-831	283	3	.	.	PUNCT
admet-831	284	1	587	587	NUM
admet-831	284	2	(	(	PUNCT
admet-831	284	3	2013	2013	NUM
admet-831	284	4	)	)	PUNCT
admet-831	284	5	1089	1089	NUM
admet-831	284	6	-	-	SYM
admet-831	284	7	1095	1095	NUM
admet-831	284	8	.	.	PUNCT
admet-831	285	1	[	[	X
admet-831	285	2	25	25	NUM
admet-831	285	3	]	]	X
admet-831	285	4	l.	l.	PROPN
admet-831	285	5	goldschmidt	goldschmidt	PROPN
admet-831	285	6	,	,	PUNCT
admet-831	285	7	p.k	p.k	PROPN
admet-831	285	8	.	.	PUNCT
admet-831	285	9	teng	teng	PROPN
admet-831	285	10	,	,	PUNCT
admet-831	285	11	r.	r.	PROPN
admet-831	285	12	riek	riek	PROPN
admet-831	285	13	,	,	PUNCT
admet-831	285	14	d.	d.	PROPN
admet-831	285	15	eisenberg	eisenberg	PROPN
admet-831	285	16	.	.	PUNCT
admet-831	286	1	identifying	identify	VERB
admet-831	286	2	the	the	DET
admet-831	286	3	amylome	amylome	NOUN
admet-831	286	4	,	,	PUNCT
admet-831	286	5	proteins	protein	NOUN
admet-831	286	6	capable	capable	ADJ
admet-831	286	7	of	of	ADP
admet-831	286	8	forming	form	VERB
admet-831	286	9	amyloid	amyloid	NOUN
admet-831	286	10	-	-	PUNCT
admet-831	286	11	like	like	ADJ
admet-831	286	12	fibrils	fibril	NOUN
admet-831	286	13	.	.	PUNCT
admet-831	287	1	proc	proc	NOUN
admet-831	287	2	.	.	PUNCT
admet-831	288	1	natl	natl	PROPN
admet-831	288	2	.	.	PUNCT
admet-831	289	1	acad	acad	PROPN
admet-831	289	2	.	.	PUNCT
admet-831	290	1	sci	sci	PROPN
admet-831	290	2	.	.	PUNCT
admet-831	290	3	u.	u.	PROPN
admet-831	290	4	s.	s.	PROPN
admet-831	290	5	a.	a.	PROPN
admet-831	290	6	107	107	NUM
admet-831	290	7	(	(	PUNCT
admet-831	290	8	2010	2010	NUM
admet-831	290	9	)	)	PUNCT
admet-831	290	10	3487	3487	NUM
admet-831	290	11	-	-	SYM
admet-831	290	12	3492	3492	NUM
admet-831	290	13	.	.	PUNCT
admet-831	291	1	[	[	X
admet-831	291	2	26	26	NUM
admet-831	291	3	]	]	X
admet-831	291	4	e.	e.	PROPN
admet-831	291	5	monsellier	monsellier	PROPN
admet-831	291	6	,	,	PUNCT
admet-831	291	7	f.	f.	PROPN
admet-831	291	8	chiti	chiti	PROPN
admet-831	291	9	.	.	PUNCT
admet-831	291	10	prevention	prevention	NOUN
admet-831	291	11	of	of	ADP
admet-831	291	12	amyloid	amyloid	NOUN
admet-831	291	13	-	-	PUNCT
admet-831	291	14	like	like	ADJ
admet-831	291	15	aggregation	aggregation	NOUN
admet-831	291	16	as	as	ADP
admet-831	291	17	a	a	DET
admet-831	291	18	driving	drive	VERB
admet-831	291	19	force	force	NOUN
admet-831	291	20	of	of	ADP
admet-831	291	21	protein	protein	NOUN
admet-831	291	22	evolution	evolution	NOUN
admet-831	291	23	.	.	PUNCT
admet-831	292	1	embo	embo	PROPN
admet-831	292	2	rep	rep	PROPN
admet-831	292	3	.	.	PROPN
admet-831	292	4	8	8	NUM
admet-831	292	5	(	(	PUNCT
admet-831	292	6	2007	2007	NUM
admet-831	292	7	)	)	PUNCT
admet-831	292	8	737	737	NUM
admet-831	292	9	-	-	SYM
admet-831	292	10	742	742	NUM
admet-831	292	11	.	.	PUNCT
admet-831	293	1	[	[	X
admet-831	293	2	27	27	NUM
admet-831	293	3	]	]	X
admet-831	293	4	n.b	n.b	PROPN
admet-831	293	5	.	.	PROPN
admet-831	293	6	nillegoda	nillegoda	PROPN
admet-831	293	7	,	,	PUNCT
admet-831	293	8	a.s	a.s	PROPN
admet-831	293	9	.	.	PROPN
admet-831	293	10	wentink	wentink	PROPN
admet-831	293	11	,	,	PUNCT
admet-831	293	12	b.	b.	PROPN
admet-831	293	13	bukau	bukau	NOUN
admet-831	293	14	.	.	PUNCT
admet-831	294	1	protein	protein	NOUN
admet-831	294	2	disaggregation	disaggregation	NOUN
admet-831	294	3	in	in	ADP
admet-831	294	4	multicellular	multicellular	ADJ
admet-831	294	5	organisms	organism	NOUN
admet-831	294	6	.	.	PUNCT
admet-831	295	1	trends	trend	NOUN
admet-831	295	2	biochem	biochem	PROPN
admet-831	295	3	.	.	PUNCT
admet-831	296	1	sci	sci	PROPN
admet-831	296	2	.	.	PROPN
admet-831	297	1	43	43	NUM
admet-831	297	2	(	(	PUNCT
admet-831	297	3	2018	2018	NUM
admet-831	297	4	)	)	PUNCT
admet-831	297	5	285	285	NUM
admet-831	297	6	-	-	SYM
admet-831	297	7	300	300	NUM
admet-831	297	8	.	.	PUNCT
admet-831	298	1	[	[	X
admet-831	298	2	28	28	NUM
admet-831	298	3	]	]	X
admet-831	298	4	p.	p.	PROPN
admet-831	298	5	rawat	rawat	PROPN
admet-831	298	6	,	,	PUNCT
admet-831	298	7	r.	r.	PROPN
admet-831	298	8	prabakaran	prabakaran	PROPN
admet-831	298	9	,	,	PUNCT
admet-831	298	10	r.	r.	PROPN
admet-831	298	11	sakthivel	sakthivel	PROPN
admet-831	298	12	,	,	PUNCT
admet-831	298	13	a.	a.	PROPN
admet-831	298	14	mary	mary	PROPN
admet-831	298	15	thangakani	thangakani	PROPN
admet-831	298	16	,	,	PUNCT
admet-831	298	17	s.	s.	PROPN
admet-831	298	18	kumar	kumar	PROPN
admet-831	298	19	,	,	PUNCT
admet-831	298	20	m.m	m.m	PROPN
admet-831	298	21	.	.	PROPN
admet-831	298	22	gromiha	gromiha	PROPN
admet-831	298	23	.	.	PUNCT
admet-831	299	1	cpad	cpad	NOUN
admet-831	299	2	2.0	2.0	NUM
admet-831	299	3	:	:	PUNCT
admet-831	299	4	a	a	DET
admet-831	299	5	repository	repository	NOUN
admet-831	299	6	of	of	ADP
admet-831	299	7	curated	curate	VERB
admet-831	299	8	experimental	experimental	ADJ
admet-831	299	9	data	datum	NOUN
admet-831	299	10	on	on	ADP
admet-831	299	11	aggregating	aggregate	VERB
admet-831	299	12	proteins	protein	NOUN
admet-831	299	13	and	and	CCONJ
admet-831	299	14	peptides	peptide	NOUN
admet-831	299	15	.	.	PUNCT
admet-831	300	1	amyloid	amyloid	NOUN
admet-831	300	2	(	(	PUNCT
admet-831	300	3	2020	2020	NUM
admet-831	300	4	)	)	PUNCT
admet-831	300	5	1	1	NUM
admet-831	300	6	-	-	SYM
admet-831	300	7	6	6	NUM
admet-831	300	8	.	.	PUNCT
admet-831	301	1	[	[	X
admet-831	301	2	29	29	NUM
admet-831	301	3	]	]	X
admet-831	301	4	p.p	p.p	PROPN
admet-831	301	5	.	.	PROPN
admet-831	301	6	wozniak	wozniak	PROPN
admet-831	301	7	,	,	PUNCT
admet-831	301	8	m.	m.	NOUN
admet-831	301	9	kotulska	kotulska	PROPN
admet-831	301	10	.	.	PUNCT
admet-831	301	11	amyload	amyload	PROPN
admet-831	301	12	:	:	PUNCT
admet-831	301	13	website	website	NOUN
admet-831	301	14	dedicated	dedicate	VERB
admet-831	301	15	to	to	ADP
admet-831	301	16	amyloidogenic	amyloidogenic	ADJ
admet-831	301	17	protein	protein	NOUN
admet-831	301	18	fragments	fragment	NOUN
admet-831	301	19	.	.	PUNCT
admet-831	302	1	bioinformatics	bioinformatic	NOUN
admet-831	302	2	31	31	NUM
admet-831	302	3	(	(	PUNCT
admet-831	302	4	2015	2015	NUM
admet-831	302	5	)	)	PUNCT
admet-831	302	6	3395	3395	NUM
admet-831	302	7	-	-	SYM
admet-831	302	8	3397	3397	NUM
admet-831	302	9	.	.	PUNCT
admet-831	303	1	[	[	X
admet-831	303	2	30	30	NUM
admet-831	303	3	]	]	PUNCT
admet-831	303	4	m.	m.	NOUN
admet-831	303	5	varadi	varadi	NOUN
admet-831	303	6	,	,	PUNCT
admet-831	303	7	g.	g.	PROPN
admet-831	303	8	de	de	X
admet-831	303	9	baets	baets	PROPN
admet-831	303	10	,	,	PUNCT
admet-831	303	11	w.f	w.f	PROPN
admet-831	303	12	.	.	PROPN
admet-831	303	13	vranken	vranken	PROPN
admet-831	303	14	,	,	PUNCT
admet-831	303	15	p.	p.	NOUN
admet-831	303	16	tompa	tompa	PROPN
admet-831	303	17	,	,	PUNCT
admet-831	303	18	r.	r.	PROPN
admet-831	303	19	pancsa	pancsa	PROPN
admet-831	303	20	.	.	PUNCT
admet-831	304	1	amypro	amypro	PROPN
admet-831	304	2	:	:	PUNCT
admet-831	304	3	a	a	DET
admet-831	304	4	database	database	NOUN
admet-831	304	5	of	of	ADP
admet-831	304	6	proteins	protein	NOUN
admet-831	304	7	with	with	ADP
admet-831	304	8	validated	validated	ADJ
admet-831	304	9	amyloidogenic	amyloidogenic	ADJ
admet-831	304	10	regions	region	NOUN
admet-831	304	11	.	.	PUNCT
admet-831	305	1	nucleic	nucleic	ADJ
admet-831	305	2	acids	acid	NOUN
admet-831	305	3	res	re	NOUN
admet-831	305	4	.	.	PUNCT
admet-831	306	1	46	46	NUM
admet-831	306	2	(	(	PUNCT
admet-831	306	3	2018	2018	NUM
admet-831	306	4	)	)	PUNCT
admet-831	307	1	d387	d387	PROPN
admet-831	307	2	-	-	PUNCT
admet-831	307	3	d392	d392	PROPN
admet-831	307	4	.	.	PUNCT
admet-831	308	1	[	[	X
admet-831	308	2	31	31	NUM
admet-831	308	3	]	]	X
admet-831	308	4	o.	o.	PROPN
admet-831	308	5	conchillo	conchillo	PROPN
admet-831	308	6	-	-	PROPN
admet-831	308	7	sole	sole	NOUN
admet-831	308	8	,	,	PUNCT
admet-831	308	9	n.s	n.s	PROPN
admet-831	308	10	.	.	PROPN
admet-831	308	11	de	de	PROPN
admet-831	308	12	groot	groot	PROPN
admet-831	308	13	,	,	PUNCT
admet-831	308	14	f.x	f.x	PROPN
admet-831	308	15	.	.	PROPN
admet-831	308	16	aviles	aviles	PROPN
admet-831	308	17	,	,	PUNCT
admet-831	308	18	j.	j.	PROPN
admet-831	308	19	vendrell	vendrell	PROPN
admet-831	308	20	,	,	PUNCT
admet-831	308	21	x.	x.	PROPN
admet-831	308	22	daura	daura	PROPN
admet-831	308	23	,	,	PUNCT
admet-831	308	24	s.	s.	PROPN
admet-831	308	25	ventura	ventura	PROPN
admet-831	308	26	.	.	PUNCT
admet-831	308	27	aggrescan	aggrescan	PROPN
admet-831	308	28	:	:	PUNCT
admet-831	308	29	a	a	DET
admet-831	308	30	server	server	NOUN
admet-831	308	31	for	for	ADP
admet-831	308	32	the	the	DET
admet-831	308	33	prediction	prediction	NOUN
admet-831	308	34	and	and	CCONJ
admet-831	308	35	evaluation	evaluation	NOUN
admet-831	308	36	of	of	ADP
admet-831	308	37	"	"	PUNCT
admet-831	308	38	hot	hot	ADJ
admet-831	308	39	spots	spot	NOUN
admet-831	308	40	"	"	PUNCT
admet-831	308	41	of	of	ADP
admet-831	308	42	aggregation	aggregation	NOUN
admet-831	308	43	in	in	ADP
admet-831	308	44	polypeptides	polypeptide	NOUN
admet-831	308	45	.	.	PUNCT
admet-831	309	1	bmc	bmc	ADJ
admet-831	309	2	bioinformatics	bioinformatics	NOUN
admet-831	309	3	8	8	NUM
admet-831	309	4	(	(	PUNCT
admet-831	309	5	2007	2007	NUM
admet-831	309	6	)	)	PUNCT
admet-831	309	7	65	65	NUM
admet-831	309	8	.	.	PUNCT
admet-831	310	1	[	[	X
admet-831	310	2	32	32	NUM
admet-831	310	3	]	]	PUNCT
admet-831	310	4	r.	r.	PROPN
admet-831	310	5	zambrano	zambrano	PROPN
admet-831	310	6	,	,	PUNCT
admet-831	310	7	m.	m.	PROPN
admet-831	310	8	jamroz	jamroz	PROPN
admet-831	310	9	,	,	PUNCT
admet-831	310	10	a.	a.	NOUN
admet-831	310	11	szczasiuk	szczasiuk	NOUN
admet-831	310	12	,	,	PUNCT
admet-831	310	13	j.	j.	PROPN
admet-831	310	14	pujols	pujols	PROPN
admet-831	310	15	,	,	PUNCT
admet-831	310	16	s.	s.	PROPN
admet-831	310	17	kmiecik	kmiecik	PROPN
admet-831	310	18	,	,	PUNCT
admet-831	310	19	s.	s.	PROPN
admet-831	310	20	ventura	ventura	PROPN
admet-831	310	21	.	.	PUNCT
admet-831	311	1	aggrescan3d	aggrescan3d	PROPN
admet-831	311	2	(	(	PUNCT
admet-831	311	3	a3d	a3d	X
admet-831	311	4	):	):	PUNCT
admet-831	311	5	server	server	NOUN
admet-831	311	6	for	for	ADP
admet-831	311	7	prediction	prediction	NOUN
admet-831	311	8	of	of	ADP
admet-831	311	9	aggregation	aggregation	NOUN
admet-831	311	10	properties	property	NOUN
admet-831	311	11	of	of	ADP
admet-831	311	12	protein	protein	NOUN
admet-831	311	13	structures	structure	NOUN
admet-831	311	14	.	.	PUNCT
admet-831	312	1	nucleic	nucleic	ADJ
admet-831	312	2	acids	acid	NOUN
admet-831	312	3	res	re	NOUN
admet-831	312	4	.	.	PUNCT
admet-831	313	1	43	43	NUM
admet-831	313	2	(	(	PUNCT
admet-831	313	3	2015	2015	NUM
admet-831	313	4	)	)	PUNCT
admet-831	313	5	w306w313	w306w313	X
admet-831	313	6	.	.	PUNCT
admet-831	314	1	[	[	X
admet-831	314	2	33	33	NUM
admet-831	314	3	]	]	X
admet-831	314	4	k.k	k.k	PROPN
admet-831	314	5	.	.	PROPN
admet-831	314	6	frousios	frousios	PROPN
admet-831	314	7	,	,	PUNCT
admet-831	314	8	v.a	v.a	PROPN
admet-831	314	9	.	.	PROPN
admet-831	314	10	iconomidou	iconomidou	PROPN
admet-831	314	11	,	,	PUNCT
admet-831	314	12	c.m	c.m	PROPN
admet-831	314	13	.	.	PROPN
admet-831	314	14	karletidi	karletidi	PROPN
admet-831	314	15	,	,	PUNCT
admet-831	314	16	s.j	s.j	PROPN
admet-831	314	17	.	.	PROPN
admet-831	314	18	hamodrakas	hamodrakas	PROPN
admet-831	314	19	.	.	PUNCT
admet-831	315	1	amyloidogenic	amyloidogenic	ADJ
admet-831	315	2	determinants	determinant	NOUN
admet-831	315	3	are	be	AUX
admet-831	315	4	usually	usually	ADV
admet-831	315	5	not	not	PART
admet-831	315	6	buried	bury	VERB
admet-831	315	7	.	.	PUNCT
admet-831	316	1	bmc	bmc	PROPN
admet-831	316	2	struct	struct	NOUN
admet-831	316	3	biol	biol	NOUN
admet-831	316	4	.	.	PUNCT
admet-831	317	1	(	(	PUNCT
admet-831	317	2	2009	2009	NUM
admet-831	317	3	)	)	PUNCT
admet-831	317	4	jul	jul	PROPN
admet-831	317	5	9	9	NUM
admet-831	317	6	;	;	PUNCT
admet-831	317	7	9:44	9:44	NUM
admet-831	317	8	.	.	PUNCT
admet-831	317	9	doi	doi	NOUN
admet-831	317	10	:	:	PUNCT
admet-831	317	11	https://doi.org/10.1186/1472-6807-9-44	https://doi.org/10.1186/1472-6807-9-44	PROPN
admet-831	317	12	.	.	PUNCT
admet-831	318	1	[	[	X
admet-831	318	2	34	34	NUM
admet-831	318	3	]	]	SYM
admet-831	318	4	a.b	a.b	PROPN
admet-831	318	5	.	.	PROPN
admet-831	318	6	ahmed	ahmed	PROPN
admet-831	318	7	,	,	PUNCT
admet-831	318	8	n.	n.	PROPN
admet-831	318	9	znassi	znassi	PROPN
admet-831	318	10	,	,	PUNCT
admet-831	318	11	m.t	m.t	PROPN
admet-831	318	12	.	.	PROPN
admet-831	318	13	chateau	chateau	PROPN
admet-831	318	14	,	,	PUNCT
admet-831	318	15	a.v	a.v	PROPN
admet-831	318	16	.	.	PROPN
admet-831	318	17	kajava	kajava	PROPN
admet-831	318	18	.	.	PUNCT
admet-831	319	1	a	a	DET
admet-831	319	2	structure	structure	NOUN
admet-831	319	3	-	-	PUNCT
admet-831	319	4	based	base	VERB
admet-831	319	5	approach	approach	NOUN
admet-831	319	6	to	to	PART
admet-831	319	7	predict	predict	VERB
admet-831	319	8	predisposition	predisposition	NOUN
admet-831	319	9	to	to	ADP
admet-831	319	10	amyloidosis	amyloidosis	NOUN
admet-831	319	11	.	.	PUNCT
admet-831	320	1	alzheimers	alzheimers	PROPN
admet-831	320	2	dement	dement	PROPN
admet-831	320	3	.	.	PUNCT
admet-831	321	1	11	11	NUM
admet-831	321	2	(	(	PUNCT
admet-831	321	3	2015	2015	NUM
admet-831	321	4	)	)	PUNCT
admet-831	321	5	681	681	NUM
admet-831	321	6	-	-	SYM
admet-831	321	7	690	690	NUM
admet-831	321	8	.	.	PUNCT
admet-831	322	1	[	[	X
admet-831	322	2	35	35	NUM
admet-831	322	3	]	]	X
admet-831	322	4	s.o	s.o	PROPN
admet-831	322	5	.	.	PROPN
admet-831	322	6	garbuzynskiy	garbuzynskiy	PROPN
admet-831	322	7	,	,	PUNCT
admet-831	322	8	m.y	m.y	PROPN
admet-831	322	9	.	.	PROPN
admet-831	322	10	lobanov	lobanov	PROPN
admet-831	322	11	,	,	PUNCT
admet-831	322	12	o.v	o.v	PROPN
admet-831	322	13	.	.	PROPN
admet-831	322	14	galzitskaya	galzitskaya	PROPN
admet-831	322	15	.	.	PUNCT
admet-831	323	1	foldamyloid	foldamyloid	ADJ
admet-831	323	2	:	:	PUNCT
admet-831	323	3	a	a	DET
admet-831	323	4	method	method	NOUN
admet-831	323	5	of	of	ADP
admet-831	323	6	prediction	prediction	NOUN
admet-831	323	7	of	of	ADP
admet-831	323	8	amyloidogenic	amyloidogenic	ADJ
admet-831	323	9	regions	region	NOUN
admet-831	323	10	from	from	ADP
admet-831	323	11	protein	protein	NOUN
admet-831	323	12	sequence	sequence	NOUN
admet-831	323	13	.	.	PUNCT
admet-831	324	1	bioinformatics	bioinformatics	NOUN
admet-831	324	2	.	.	PUNCT
admet-831	325	1	26(3	26(3	NUM
admet-831	325	2	)	)	PUNCT
admet-831	325	3	(	(	PUNCT
admet-831	325	4	2010	2010	NUM
admet-831	325	5	)	)	PUNCT
admet-831	325	6	326	326	NUM
admet-831	325	7	-	-	SYM
admet-831	325	8	332	332	NUM
admet-831	325	9	.	.	PUNCT
admet-831	326	1	doi	doi	NOUN
admet-831	326	2	:	:	PUNCT
admet-831	326	3	https://doi.org/10.1093/bioinformatics/btp691	https://doi.org/10.1093/bioinformatics/btp691	NOUN
admet-831	326	4	.	.	PUNCT
admet-831	327	1	[	[	X
admet-831	327	2	36	36	NUM
admet-831	327	3	]	]	PUNCT
admet-831	327	4	m.	m.	NOUN
admet-831	327	5	emily	emily	PROPN
admet-831	327	6	,	,	PUNCT
admet-831	327	7	a.	a.	NOUN
admet-831	327	8	talvas	talvas	PROPN
admet-831	327	9	,	,	PUNCT
admet-831	327	10	c.	c.	PROPN
admet-831	327	11	delamarche	delamarche	PROPN
admet-831	327	12	.	.	PUNCT
admet-831	328	1	metamyl	metamyl	PROPN
admet-831	328	2	:	:	PUNCT
admet-831	328	3	a	a	DET
admet-831	328	4	meta	meta	ADJ
admet-831	328	5	-	-	PUNCT
admet-831	328	6	predictor	predictor	NOUN
admet-831	328	7	for	for	ADP
admet-831	328	8	amyloid	amyloid	NOUN
admet-831	328	9	proteins	protein	NOUN
admet-831	328	10	.	.	PUNCT
admet-831	329	1	plos	plos	PROPN
admet-831	329	2	one	one	NUM
admet-831	329	3	.	.	PUNCT
admet-831	330	1	8(11	8(11	NUM
admet-831	330	2	)	)	PUNCT
admet-831	330	3	(	(	PUNCT
admet-831	330	4	2013	2013	NUM
admet-831	330	5	)	)	PUNCT
admet-831	330	6	e79722	e79722	NOUN
admet-831	330	7	.	.	PUNCT
admet-831	331	1	doi	doi	NOUN
admet-831	331	2	:	:	PUNCT
admet-831	331	3	https://doi.org/10.1371/journal.pone.0079722	https://doi.org/10.1371/journal.pone.0079722	NOUN
admet-831	331	4	.	.	PUNCT
admet-831	332	1	[	[	X
admet-831	332	2	37	37	NUM
admet-831	332	3	]	]	X
admet-831	332	4	i.	i.	PROPN
admet-831	332	5	walsh	walsh	PROPN
admet-831	332	6	,	,	PUNCT
admet-831	332	7	f.	f.	PROPN
admet-831	332	8	seno	seno	PROPN
admet-831	332	9	,	,	PUNCT
admet-831	332	10	s.c	s.c	PROPN
admet-831	332	11	.	.	PROPN
admet-831	332	12	tosatto	tosatto	PROPN
admet-831	332	13	,	,	PUNCT
admet-831	332	14	a.	a.	PROPN
admet-831	332	15	trovato	trovato	PROPN
admet-831	332	16	.	.	PUNCT
admet-831	333	1	pasta	pasta	NOUN
admet-831	333	2	2.0	2.0	NUM
admet-831	333	3	:	:	PUNCT
admet-831	333	4	an	an	DET
admet-831	333	5	improved	improved	ADJ
admet-831	333	6	server	server	NOUN
admet-831	333	7	for	for	ADP
admet-831	333	8	protein	protein	NOUN
admet-831	333	9	aggregation	aggregation	NOUN
admet-831	333	10	prediction	prediction	NOUN
admet-831	333	11	.	.	PUNCT
admet-831	334	1	nucleic	nucleic	ADJ
admet-831	334	2	acids	acid	NOUN
admet-831	334	3	res	re	NOUN
admet-831	334	4	42	42	NUM
admet-831	334	5	(	(	PUNCT
admet-831	334	6	2014	2014	NUM
admet-831	334	7	)	)	PUNCT
admet-831	335	1	w301	w301	PROPN
admet-831	335	2	-	-	PUNCT
admet-831	335	3	w307	w307	PROPN
admet-831	335	4	.	.	PUNCT
admet-831	336	1	[	[	X
admet-831	336	2	38	38	NUM
admet-831	336	3	]	]	PUNCT
admet-831	336	4	a.m.	a.m.	NOUN
admet-831	336	5	fernandez	fernandez	PROPN
admet-831	336	6	-	-	PUNCT
admet-831	336	7	escamilla	escamilla	PROPN
admet-831	336	8	,	,	PUNCT
admet-831	336	9	f.	f.	PROPN
admet-831	336	10	rousseau	rousseau	PROPN
admet-831	336	11	,	,	PUNCT
admet-831	336	12	j.	j.	PROPN
admet-831	336	13	schymkowitz	schymkowitz	PROPN
admet-831	336	14	,	,	PUNCT
admet-831	336	15	l.	l.	PROPN
admet-831	336	16	serrano	serrano	PROPN
admet-831	336	17	.	.	PUNCT
admet-831	337	1	prediction	prediction	NOUN
admet-831	337	2	of	of	ADP
admet-831	337	3	sequencedependent	sequencedependent	NOUN
admet-831	337	4	and	and	CCONJ
admet-831	337	5	mutational	mutational	ADJ
admet-831	337	6	effects	effect	NOUN
admet-831	337	7	on	on	ADP
admet-831	337	8	the	the	DET
admet-831	337	9	aggregation	aggregation	NOUN
admet-831	337	10	of	of	ADP
admet-831	337	11	peptides	peptide	NOUN
admet-831	337	12	and	and	CCONJ
admet-831	337	13	proteins	protein	NOUN
admet-831	337	14	.	.	PUNCT
admet-831	338	1	nat	nat	NOUN
admet-831	338	2	.	.	PUNCT
admet-831	339	1	biotechnol	biotechnol	PROPN
admet-831	339	2	.	.	PUNCT
admet-831	340	1	22	22	NUM
admet-831	340	2	(	(	PUNCT
admet-831	340	3	2004	2004	NUM
admet-831	340	4	)	)	PUNCT
admet-831	340	5	1302	1302	NUM
admet-831	340	6	-	-	SYM
admet-831	340	7	1306	1306	NUM
admet-831	340	8	.	.	PUNCT
admet-831	341	1	[	[	X
admet-831	341	2	39	39	NUM
admet-831	341	3	]	]	X
admet-831	341	4	k.l	k.l	PROPN
admet-831	341	5	.	.	PROPN
admet-831	341	6	morris	morris	PROPN
admet-831	341	7	,	,	PUNCT
admet-831	341	8	a.	a.	NOUN
admet-831	341	9	rodger	rodger	PROPN
admet-831	341	10	,	,	PUNCT
admet-831	341	11	m.r	m.r	PROPN
admet-831	341	12	.	.	PROPN
admet-831	341	13	hicks	hicks	PROPN
admet-831	341	14	,	,	PUNCT
admet-831	341	15	m.	m.	PROPN
admet-831	341	16	debulpaep	debulpaep	VERB
admet-831	341	17	,	,	PUNCT
admet-831	341	18	j.	j.	PROPN
admet-831	341	19	schymkowitz	schymkowitz	PROPN
admet-831	341	20	,	,	PUNCT
admet-831	341	21	f.	f.	PROPN
admet-831	341	22	rousseau	rousseau	PROPN
admet-831	341	23	,	,	PUNCT
admet-831	341	24	l.c	l.c	PROPN
admet-831	341	25	.	.	PROPN
admet-831	341	26	serpell	serpell	PROPN
admet-831	341	27	.	.	PUNCT
admet-831	342	1	exploring	explore	VERB
admet-831	342	2	the	the	DET
admet-831	342	3	sequence	sequence	NOUN
admet-831	342	4	-	-	PUNCT
admet-831	342	5	structure	structure	NOUN
admet-831	342	6	relationship	relationship	NOUN
admet-831	342	7	for	for	ADP
admet-831	342	8	amyloid	amyloid	NOUN
admet-831	342	9	peptides	peptide	NOUN
admet-831	342	10	.	.	PUNCT
admet-831	343	1	biochem	biochem	PROPN
admet-831	343	2	j.	j.	PROPN
admet-831	343	3	450(2	450(2	PROPN
admet-831	343	4	)	)	PUNCT
admet-831	343	5	(	(	PUNCT
admet-831	343	6	2013	2013	NUM
admet-831	343	7	)	)	PUNCT
admet-831	343	8	275	275	NUM
admet-831	343	9	-	-	SYM
admet-831	343	10	283	283	NUM
admet-831	343	11	.	.	PUNCT
admet-831	344	1	doi	doi	NOUN
admet-831	344	2	:	:	PUNCT
admet-831	344	3	https://doi.org/10.1042/bj20121773	https://doi.org/10.1042/bj20121773	X
admet-831	344	4	.	.	PUNCT
admet-831	345	1	https://doi.org/10.1101/2020.02.28.962894	https://doi.org/10.1101/2020.02.28.962894	PROPN
admet-831	345	2	https://doi.org/10.1186/1472-6807-9-44	https://doi.org/10.1186/1472-6807-9-44	SYM
admet-831	345	3	https://doi.org/10.1093/bioinformatics/btp691	https://doi.org/10.1093/bioinformatics/btp691	PROPN
admet-831	345	4	https://doi.org/10.1371/journal.pone.0079722	https://doi.org/10.1371/journal.pone.0079722	X
admet-831	345	5	admet	admet	NOUN
admet-831	345	6	&	&	CCONJ
admet-831	345	7	dmpk	dmpk	PROPN
admet-831	345	8	8(4	8(4	NOUN
admet-831	345	9	)	)	PUNCT
admet-831	345	10	(	(	PUNCT
admet-831	345	11	2020	2020	NUM
admet-831	345	12	)	)	PUNCT
admet-831	345	13	391	391	NUM
admet-831	345	14	-	-	SYM
admet-831	345	15	399	399	NUM
admet-831	345	16	solubility	solubility	NOUN
admet-831	345	17	of	of	ADP
admet-831	345	18	proteins	protein	NOUN
admet-831	345	19	doi	doi	NOUN
admet-831	345	20	:	:	PUNCT
admet-831	345	21	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	NOUN
admet-831	345	22	399	399	NUM
admet-831	346	1	[	[	X
admet-831	346	2	40	40	NUM
admet-831	346	3	]	]	PUNCT
admet-831	346	4	w.	w.	PROPN
admet-831	346	5	yang	yang	PROPN
admet-831	346	6	,	,	PUNCT
admet-831	346	7	p.	p.	PROPN
admet-831	346	8	tan	tan	PROPN
admet-831	346	9	,	,	PUNCT
admet-831	346	10	x.	x.	NOUN
admet-831	346	11	fu	fu	PROPN
admet-831	346	12	,	,	PUNCT
admet-831	346	13	l.	l.	PROPN
admet-831	346	14	hong	hong	PROPN
admet-831	346	15	.	.	PUNCT
admet-831	347	1	prediction	prediction	NOUN
admet-831	347	2	of	of	ADP
admet-831	347	3	amyloid	amyloid	NOUN
admet-831	347	4	aggregation	aggregation	NOUN
admet-831	347	5	rates	rate	NOUN
admet-831	347	6	by	by	ADP
admet-831	347	7	machine	machine	NOUN
admet-831	347	8	learning	learning	NOUN
admet-831	347	9	and	and	CCONJ
admet-831	347	10	feature	feature	NOUN
admet-831	347	11	selection	selection	NOUN
admet-831	347	12	.	.	PUNCT
admet-831	348	1	j.	j.	PROPN
admet-831	348	2	chem	chem	PROPN
admet-831	348	3	.	.	PUNCT
admet-831	349	1	phys	phy	NOUN
admet-831	349	2	.	.	PUNCT
admet-831	350	1	151	151	NUM
admet-831	350	2	(	(	PUNCT
admet-831	350	3	2019	2019	NUM
admet-831	350	4	)	)	PUNCT
admet-831	350	5	084106	084106	NUM
admet-831	350	6	.	.	PUNCT
admet-831	351	1	[	[	X
admet-831	351	2	41	41	NUM
admet-831	351	3	]	]	X
admet-831	351	4	d.b	d.b	PROPN
admet-831	351	5	.	.	PROPN
admet-831	351	6	roche	roche	PROPN
admet-831	351	7	,	,	PUNCT
admet-831	351	8	e.	e.	PROPN
admet-831	351	9	villain	villain	PROPN
admet-831	351	10	,	,	PUNCT
admet-831	351	11	a.v	a.v	PROPN
admet-831	351	12	.	.	PROPN
admet-831	351	13	kajava	kajava	PROPN
admet-831	351	14	.	.	PUNCT
admet-831	352	1	usage	usage	NOUN
admet-831	352	2	of	of	ADP
admet-831	352	3	a	a	DET
admet-831	352	4	dataset	dataset	NOUN
admet-831	352	5	of	of	ADP
admet-831	352	6	nmr	nmr	NOUN
admet-831	352	7	resolved	resolve	VERB
admet-831	352	8	protein	protein	NOUN
admet-831	352	9	structures	structure	NOUN
admet-831	352	10	to	to	PART
admet-831	352	11	test	test	VERB
admet-831	352	12	aggregation	aggregation	NOUN
admet-831	352	13	versus	versus	ADP
admet-831	352	14	solubility	solubility	NOUN
admet-831	352	15	prediction	prediction	NOUN
admet-831	352	16	algorithms	algorithm	NOUN
admet-831	352	17	.	.	PUNCT
admet-831	353	1	protein	protein	NOUN
admet-831	353	2	sci	sci	PROPN
admet-831	353	3	.	.	PROPN
admet-831	353	4	26	26	NUM
admet-831	353	5	(	(	PUNCT
admet-831	353	6	2017	2017	NUM
admet-831	353	7	)	)	PUNCT
admet-831	353	8	1864	1864	NUM
admet-831	353	9	-	-	SYM
admet-831	353	10	1869	1869	NUM
admet-831	353	11	.	.	PUNCT
admet-831	354	1	[	[	X
admet-831	354	2	42	42	NUM
admet-831	354	3	]	]	PUNCT
admet-831	354	4	a.	a.	NOUN
admet-831	354	5	meulemans	meulemans	PROPN
admet-831	354	6	,	,	PUNCT
admet-831	354	7	s.	s.	PROPN
admet-831	354	8	seneca	seneca	PROPN
admet-831	354	9	,	,	PUNCT
admet-831	354	10	t.	t.	PROPN
admet-831	354	11	pribyl	pribyl	PROPN
admet-831	354	12	,	,	PUNCT
admet-831	354	13	j.	j.	PROPN
admet-831	354	14	smet	smet	PROPN
admet-831	354	15	,	,	PUNCT
admet-831	354	16	v.	v.	CCONJ
admet-831	354	17	alderweirldt	alderweirldt	ADJ
admet-831	354	18	,	,	PUNCT
admet-831	354	19	a.	a.	NOUN
admet-831	354	20	waeytens	waeytens	PROPN
admet-831	354	21	,	,	PUNCT
admet-831	354	22	w.	w.	PROPN
admet-831	354	23	lissens	lissens	PROPN
admet-831	354	24	,	,	PUNCT
admet-831	354	25	r.	r.	PROPN
admet-831	354	26	van	van	PROPN
admet-831	354	27	coster	coster	PROPN
admet-831	354	28	,	,	PUNCT
admet-831	354	29	l.	l.	PROPN
admet-831	354	30	de	de	PROPN
admet-831	354	31	meirleir	meirleir	PROPN
admet-831	354	32	,	,	PUNCT
admet-831	354	33	j.p	j.p	PROPN
admet-831	354	34	.	.	PROPN
admet-831	354	35	di	di	PROPN
admet-831	354	36	rago	rago	PROPN
admet-831	354	37	,	,	PUNCT
admet-831	354	38	d.l	d.l	PROPN
admet-831	354	39	.	.	PROPN
admet-831	354	40	gatti	gatti	PROPN
admet-831	354	41	,	,	PUNCT
admet-831	354	42	s.h	s.h	PROPN
admet-831	354	43	.	.	PROPN
admet-831	354	44	ackerman	ackerman	PROPN
admet-831	354	45	.	.	PUNCT
admet-831	355	1	defining	define	VERB
admet-831	355	2	the	the	DET
admet-831	355	3	pathogenesis	pathogenesis	NOUN
admet-831	355	4	of	of	ADP
admet-831	355	5	the	the	DET
admet-831	355	6	human	human	PROPN
admet-831	355	7	atp12p	atp12p	PROPN
admet-831	355	8	w94r	w94r	PROPN
admet-831	355	9	mutation	mutation	NOUN
admet-831	355	10	using	use	VERB
admet-831	355	11	a	a	DET
admet-831	355	12	saccharomyces	saccharomyce	NOUN
admet-831	355	13	cerevisiae	cerevisiae	NOUN
admet-831	355	14	yeast	yeast	NOUN
admet-831	355	15	model	model	NOUN
admet-831	355	16	.	.	PUNCT
admet-831	356	1	j.	j.	PROPN
admet-831	356	2	biol	biol	PROPN
admet-831	356	3	.	.	PUNCT
admet-831	357	1	chem	chem	PROPN
admet-831	357	2	.	.	PUNCT
admet-831	358	1	285	285	NUM
admet-831	358	2	(	(	PUNCT
admet-831	358	3	2010	2010	NUM
admet-831	358	4	)	)	PUNCT
admet-831	358	5	4099	4099	NUM
admet-831	358	6	-	-	SYM
admet-831	358	7	4109	4109	NUM
admet-831	358	8	.	.	PUNCT
admet-831	359	1	[	[	X
admet-831	359	2	43	43	NUM
admet-831	359	3	]	]	X
admet-831	359	4	u.p	u.p	PROPN
admet-831	359	5	.	.	PROPN
admet-831	359	6	andley	andley	PROPN
admet-831	359	7	,	,	PUNCT
admet-831	359	8	m.a	m.a	PROPN
admet-831	359	9	.	.	PROPN
admet-831	359	10	reilly	reilly	PROPN
admet-831	359	11	.	.	PUNCT
admet-831	360	1	in	in	ADP
admet-831	360	2	vivo	vivo	ADJ
admet-831	360	3	lens	lens	NOUN
admet-831	360	4	deficiency	deficiency	NOUN
admet-831	360	5	of	of	ADP
admet-831	360	6	the	the	DET
admet-831	360	7	r49c	r49c	NOUN
admet-831	360	8	alphaa	alphaa	NOUN
admet-831	360	9	-	-	PUNCT
admet-831	360	10	crystallin	crystallin	NOUN
admet-831	360	11	mutant	mutant	NOUN
admet-831	360	12	.	.	PUNCT
admet-831	361	1	exp	exp	NOUN
admet-831	361	2	.	.	PUNCT
admet-831	361	3	eye	eye	NOUN
admet-831	361	4	res	re	NOUN
admet-831	361	5	.	.	PUNCT
admet-831	362	1	90	90	NUM
admet-831	362	2	(	(	PUNCT
admet-831	362	3	2010	2010	NUM
admet-831	362	4	)	)	PUNCT
admet-831	362	5	699	699	NUM
admet-831	362	6	-	-	SYM
admet-831	362	7	702	702	NUM
admet-831	362	8	.	.	PUNCT
admet-831	363	1	[	[	X
admet-831	363	2	44	44	NUM
admet-831	363	3	]	]	X
admet-831	363	4	g.a.p	g.a.p	ADJ
admet-831	363	5	.	.	PUNCT
admet-831	363	6	de	de	PROPN
admet-831	363	7	oliveira	oliveira	PROPN
admet-831	363	8	,	,	PUNCT
admet-831	363	9	y.	y.	PROPN
admet-831	363	10	cordeiro	cordeiro	PROPN
admet-831	363	11	,	,	PUNCT
admet-831	363	12	j.l	j.l	PROPN
admet-831	363	13	.	.	PROPN
admet-831	363	14	silva	silva	PROPN
admet-831	363	15	,	,	PUNCT
admet-831	363	16	t.	t.	PROPN
admet-831	363	17	vieira	vieira	PROPN
admet-831	363	18	.	.	PUNCT
admet-831	364	1	liquid	liquid	NOUN
admet-831	364	2	-	-	PUNCT
admet-831	364	3	liquid	liquid	ADJ
admet-831	364	4	phase	phase	NOUN
admet-831	364	5	transitions	transition	NOUN
admet-831	364	6	and	and	CCONJ
admet-831	364	7	amyloid	amyloid	NOUN
admet-831	364	8	aggregation	aggregation	NOUN
admet-831	364	9	in	in	ADP
admet-831	364	10	proteins	protein	NOUN
admet-831	364	11	related	relate	VERB
admet-831	364	12	to	to	ADP
admet-831	364	13	cancer	cancer	NOUN
admet-831	364	14	and	and	CCONJ
admet-831	364	15	neurodegenerative	neurodegenerative	ADJ
admet-831	364	16	diseases	disease	NOUN
admet-831	364	17	.	.	PUNCT
admet-831	365	1	adv	adv	PROPN
admet-831	365	2	.	.	PUNCT
admet-831	365	3	protein	protein	NOUN
admet-831	365	4	chem	chem	NOUN
admet-831	365	5	.	.	PUNCT
admet-831	366	1	struct	struct	NOUN
admet-831	366	2	.	.	PUNCT
admet-831	367	1	biol	biol	PROPN
admet-831	367	2	.	.	PUNCT
admet-831	368	1	118	118	NUM
admet-831	368	2	(	(	PUNCT
admet-831	368	3	2019	2019	NUM
admet-831	368	4	)	)	PUNCT
admet-831	368	5	289	289	NUM
admet-831	368	6	-	-	SYM
admet-831	368	7	331	331	NUM
admet-831	368	8	.	.	PUNCT
admet-831	369	1	[	[	X
admet-831	369	2	45	45	NUM
admet-831	369	3	]	]	PUNCT
admet-831	369	4	m.	m.	NOUN
admet-831	369	5	kanapathipillai	kanapathipillai	PROPN
admet-831	369	6	.	.	PUNCT
admet-831	370	1	treating	treat	VERB
admet-831	370	2	p53	p53	NOUN
admet-831	370	3	mutant	mutant	ADJ
admet-831	370	4	aggregation	aggregation	NOUN
admet-831	370	5	-	-	PUNCT
admet-831	370	6	associated	associate	VERB
admet-831	370	7	cancer	cancer	NOUN
admet-831	370	8	.	.	PUNCT
admet-831	371	1	cancers	cancer	NOUN
admet-831	371	2	(	(	PUNCT
admet-831	371	3	basel	basel	PROPN
admet-831	371	4	)	)	PUNCT
admet-831	371	5	10	10	NUM
admet-831	371	6	(	(	PUNCT
admet-831	371	7	2018	2018	NUM
admet-831	371	8	)	)	PUNCT
admet-831	371	9	154	154	NUM
admet-831	371	10	.	.	PUNCT
admet-831	372	1	[	[	X
admet-831	372	2	46	46	NUM
admet-831	372	3	]	]	X
admet-831	372	4	p.	p.	PROPN
admet-831	372	5	sormanni	sormanni	PROPN
admet-831	372	6	,	,	PUNCT
admet-831	372	7	f.a	f.a	PROPN
admet-831	372	8	.	.	PROPN
admet-831	372	9	aprile	aprile	PROPN
admet-831	372	10	,	,	PUNCT
admet-831	372	11	m.	m.	NOUN
admet-831	372	12	vendruscolo	vendruscolo	PROPN
admet-831	372	13	.	.	PUNCT
admet-831	373	1	the	the	DET
admet-831	373	2	camsol	camsol	PROPN
admet-831	373	3	method	method	NOUN
admet-831	373	4	of	of	ADP
admet-831	373	5	rational	rational	ADJ
admet-831	373	6	design	design	NOUN
admet-831	373	7	of	of	ADP
admet-831	373	8	protein	protein	NOUN
admet-831	373	9	mutants	mutant	NOUN
admet-831	373	10	with	with	ADP
admet-831	373	11	enhanced	enhanced	ADJ
admet-831	373	12	solubility	solubility	NOUN
admet-831	373	13	.	.	PUNCT
admet-831	374	1	j.	j.	PROPN
admet-831	374	2	mol	mol	PROPN
admet-831	374	3	.	.	PUNCT
admet-831	375	1	biol	biol	PROPN
admet-831	375	2	.	.	PUNCT
admet-831	376	1	427	427	NUM
admet-831	376	2	(	(	PUNCT
admet-831	376	3	2014	2014	NUM
admet-831	376	4	)	)	PUNCT
admet-831	376	5	478	478	NUM
admet-831	376	6	-	-	SYM
admet-831	376	7	490	490	NUM
admet-831	376	8	.	.	PUNCT
admet-831	377	1	[	[	X
admet-831	377	2	47	47	NUM
admet-831	377	3	]	]	X
admet-831	377	4	y.	y.	PROPN
admet-831	377	5	tian	tian	PROPN
admet-831	377	6	,	,	PUNCT
admet-831	377	7	c.	c.	PROPN
admet-831	377	8	deutsch	deutsch	PROPN
admet-831	377	9	,	,	PUNCT
admet-831	377	10	b.	b.	PROPN
admet-831	377	11	krishnamoorthy	krishnamoorthy	PROPN
admet-831	377	12	.	.	PUNCT
admet-831	378	1	scoring	score	VERB
admet-831	378	2	function	function	NOUN
admet-831	378	3	to	to	PART
admet-831	378	4	predict	predict	VERB
admet-831	378	5	solubility	solubility	NOUN
admet-831	378	6	mutagenesis	mutagenesis	NOUN
admet-831	378	7	.	.	PUNCT
admet-831	379	1	algorithms	algorithms	PROPN
admet-831	379	2	mol	mol	PROPN
admet-831	379	3	.	.	PUNCT
admet-831	380	1	biol	biol	PROPN
admet-831	380	2	.	.	PUNCT
admet-831	381	1	5	5	NUM
admet-831	381	2	(	(	PUNCT
admet-831	381	3	2010	2010	NUM
admet-831	381	4	)	)	PUNCT
admet-831	381	5	33	33	NUM
admet-831	381	6	.	.	PUNCT
admet-831	382	1	[	[	X
admet-831	382	2	48	48	NUM
admet-831	382	3	]	]	PUNCT
admet-831	382	4	j.	j.	PROPN
admet-831	382	5	van	van	PROPN
admet-831	382	6	durme	durme	PROPN
admet-831	382	7	,	,	PUNCT
admet-831	382	8	g.	g.	PROPN
admet-831	382	9	de	de	X
admet-831	382	10	baets	baets	PROPN
admet-831	382	11	,	,	PUNCT
admet-831	382	12	r.	r.	PROPN
admet-831	382	13	van	van	PROPN
admet-831	382	14	der	der	PROPN
admet-831	382	15	kant	kant	PROPN
admet-831	382	16	,	,	PUNCT
admet-831	382	17	m.	m.	NOUN
admet-831	382	18	ramakers	ramaker	NOUN
admet-831	382	19	,	,	PUNCT
admet-831	382	20	a.	a.	PROPN
admet-831	382	21	ganesan	ganesan	PROPN
admet-831	382	22	,	,	PUNCT
admet-831	382	23	h.	h.	PROPN
admet-831	382	24	wilkinson	wilkinson	PROPN
admet-831	382	25	,	,	PUNCT
admet-831	382	26	r.	r.	PROPN
admet-831	382	27	gallardo	gallardo	PROPN
admet-831	382	28	,	,	PUNCT
admet-831	382	29	f.	f.	PROPN
admet-831	382	30	rousseau	rousseau	PROPN
admet-831	382	31	,	,	PUNCT
admet-831	382	32	j.	j.	PROPN
admet-831	382	33	schymkowitz	schymkowitz	PROPN
admet-831	382	34	.	.	PUNCT
admet-831	383	1	solubis	solubis	PROPN
admet-831	383	2	:	:	PUNCT
admet-831	383	3	a	a	DET
admet-831	383	4	webserver	webserver	NOUN
admet-831	383	5	to	to	PART
admet-831	383	6	reduce	reduce	VERB
admet-831	383	7	protein	protein	NOUN
admet-831	383	8	aggregation	aggregation	NOUN
admet-831	383	9	through	through	ADP
admet-831	383	10	mutation	mutation	NOUN
admet-831	383	11	.	.	PUNCT
admet-831	384	1	protein	protein	NOUN
admet-831	384	2	eng	eng	PROPN
admet-831	384	3	.	.	PUNCT
admet-831	385	1	des	des	PROPN
admet-831	385	2	.	.	PROPN
admet-831	385	3	sel	sel	PROPN
admet-831	385	4	.	.	PROPN
admet-831	386	1	29	29	NUM
admet-831	386	2	(	(	PUNCT
admet-831	386	3	2016	2016	NUM
admet-831	386	4	)	)	PUNCT
admet-831	386	5	285	285	NUM
admet-831	386	6	-	-	SYM
admet-831	386	7	289	289	NUM
admet-831	386	8	.	.	PUNCT
admet-831	387	1	[	[	X
admet-831	387	2	49	49	NUM
admet-831	387	3	]	]	X
admet-831	387	4	r.	r.	PROPN
admet-831	387	5	guerois	guerois	PROPN
admet-831	387	6	,	,	PUNCT
admet-831	387	7	j.e	j.e	PROPN
admet-831	387	8	.	.	PROPN
admet-831	387	9	nielsen	nielsen	PROPN
admet-831	387	10	,	,	PUNCT
admet-831	387	11	l.	l.	PROPN
admet-831	387	12	serrano	serrano	PROPN
admet-831	387	13	.	.	PUNCT
admet-831	388	1	predicting	predict	VERB
admet-831	388	2	changes	change	NOUN
admet-831	388	3	in	in	ADP
admet-831	388	4	the	the	DET
admet-831	388	5	stability	stability	NOUN
admet-831	388	6	of	of	ADP
admet-831	388	7	proteins	protein	NOUN
admet-831	388	8	and	and	CCONJ
admet-831	388	9	protein	protein	NOUN
admet-831	388	10	complexes	complex	NOUN
admet-831	388	11	:	:	PUNCT
admet-831	388	12	a	a	DET
admet-831	388	13	study	study	NOUN
admet-831	388	14	of	of	ADP
admet-831	388	15	more	more	ADJ
admet-831	388	16	than	than	ADP
admet-831	388	17	1000	1000	NUM
admet-831	388	18	mutations	mutation	NOUN
admet-831	388	19	.	.	PUNCT
admet-831	389	1	j.	j.	PROPN
admet-831	389	2	mol	mol	PROPN
admet-831	389	3	.	.	PUNCT
admet-831	390	1	biol	biol	PROPN
admet-831	390	2	.	.	PUNCT
admet-831	391	1	320	320	NUM
admet-831	391	2	(	(	PUNCT
admet-831	391	3	2002	2002	NUM
admet-831	391	4	)	)	PUNCT
admet-831	391	5	369	369	NUM
admet-831	391	6	-	-	SYM
admet-831	391	7	387	387	NUM
admet-831	391	8	.	.	PUNCT
admet-831	392	1	[	[	X
admet-831	392	2	50	50	NUM
admet-831	392	3	]	]	PUNCT
admet-831	392	4	h.	h.	PROPN
admet-831	392	5	land	land	PROPN
admet-831	392	6	,	,	PUNCT
admet-831	392	7	m.s	m.s	PROPN
admet-831	392	8	.	.	PROPN
admet-831	392	9	humble	humble	PROPN
admet-831	392	10	.	.	PUNCT
admet-831	393	1	yasara	yasara	NOUN
admet-831	393	2	:	:	PUNCT
admet-831	393	3	a	a	DET
admet-831	393	4	tool	tool	NOUN
admet-831	393	5	to	to	PART
admet-831	393	6	obtain	obtain	VERB
admet-831	393	7	structural	structural	ADJ
admet-831	393	8	guidance	guidance	NOUN
admet-831	393	9	in	in	ADP
admet-831	393	10	biocatalytic	biocatalytic	ADJ
admet-831	393	11	investigations	investigation	NOUN
admet-831	393	12	.	.	PUNCT
admet-831	394	1	methods	method	NOUN
admet-831	394	2	mol	mol	PROPN
admet-831	394	3	.	.	PUNCT
admet-831	395	1	biol	biol	PROPN
admet-831	395	2	.	.	PUNCT
admet-831	396	1	1685	1685	NUM
admet-831	396	2	(	(	PUNCT
admet-831	396	3	2018	2018	NUM
admet-831	396	4	)	)	PUNCT
admet-831	396	5	43	43	NUM
admet-831	396	6	-	-	SYM
admet-831	396	7	67	67	NUM
admet-831	396	8	.	.	PUNCT
admet-831	397	1	[	[	X
admet-831	397	2	51	51	NUM
admet-831	397	3	]	]	X
admet-831	397	4	c.j	c.j	PROPN
admet-831	397	5	.	.	PROPN
admet-831	397	6	o'brien	o'brien	PROPN
admet-831	397	7	,	,	PUNCT
admet-831	397	8	m.a	m.a	PROPN
admet-831	397	9	.	.	PROPN
admet-831	397	10	blanco	blanco	PROPN
admet-831	397	11	,	,	PUNCT
admet-831	397	12	j.a	j.a	PROPN
admet-831	397	13	.	.	PROPN
admet-831	397	14	costanzo	costanzo	PROPN
admet-831	397	15	,	,	PUNCT
admet-831	397	16	m.	m.	NOUN
admet-831	397	17	enterline	enterline	PROPN
admet-831	397	18	,	,	PUNCT
admet-831	397	19	e.j	e.j	PROPN
admet-831	397	20	.	.	PROPN
admet-831	397	21	fernandez	fernandez	PROPN
admet-831	397	22	,	,	PUNCT
admet-831	397	23	a.s	a.s	PROPN
admet-831	397	24	.	.	PROPN
admet-831	397	25	robinson	robinson	PROPN
admet-831	397	26	,	,	PUNCT
admet-831	397	27	c.j	c.j	PROPN
admet-831	397	28	.	.	PROPN
admet-831	397	29	roberts	roberts	PROPN
admet-831	397	30	.	.	PUNCT
admet-831	398	1	modulating	modulate	VERB
admet-831	398	2	non	non	ADJ
admet-831	398	3	-	-	ADJ
admet-831	398	4	native	native	ADJ
admet-831	398	5	aggregation	aggregation	NOUN
admet-831	398	6	and	and	CCONJ
admet-831	398	7	electrostatic	electrostatic	ADJ
admet-831	398	8	protein	protein	NOUN
admet-831	398	9	-	-	PUNCT
admet-831	398	10	protein	protein	NOUN
admet-831	398	11	interactions	interaction	NOUN
admet-831	398	12	with	with	ADP
admet-831	398	13	computationally	computationally	ADV
admet-831	398	14	designed	design	VERB
admet-831	398	15	single	single	ADJ
admet-831	398	16	-	-	PUNCT
admet-831	398	17	point	point	NOUN
admet-831	398	18	mutations	mutation	NOUN
admet-831	398	19	.	.	PUNCT
admet-831	399	1	protein	protein	NOUN
admet-831	399	2	eng	eng	PROPN
admet-831	399	3	.	.	PUNCT
admet-831	400	1	des	des	PROPN
admet-831	400	2	.	.	PROPN
admet-831	400	3	sel	sel	PROPN
admet-831	400	4	.	.	PROPN
admet-831	401	1	29	29	NUM
admet-831	401	2	(	(	PUNCT
admet-831	401	3	2016	2016	NUM
admet-831	401	4	)	)	PUNCT
admet-831	401	5	231	231	NUM
admet-831	401	6	-	-	SYM
admet-831	401	7	243	243	NUM
admet-831	401	8	.	.	PUNCT
admet-831	402	1	[	[	X
admet-831	402	2	52	52	NUM
admet-831	402	3	]	]	PUNCT
admet-831	402	4	m.	m.	NOUN
admet-831	402	5	gil	gil	PROPN
admet-831	402	6	-	-	PUNCT
admet-831	402	7	garcia	garcia	PROPN
admet-831	402	8	,	,	PUNCT
admet-831	402	9	m.	m.	NOUN
admet-831	402	10	bano	bano	PROPN
admet-831	402	11	-	-	PUNCT
admet-831	402	12	polo	polo	PROPN
admet-831	402	13	,	,	PUNCT
admet-831	402	14	n.	n.	PROPN
admet-831	402	15	varejao	varejao	PROPN
admet-831	402	16	,	,	PUNCT
admet-831	402	17	m.	m.	NOUN
admet-831	402	18	jamroz	jamroz	PROPN
admet-831	402	19	,	,	PUNCT
admet-831	402	20	a.	a.	NOUN
admet-831	402	21	kuriata	kuriata	PROPN
admet-831	402	22	,	,	PUNCT
admet-831	402	23	m.	m.	PROPN
admet-831	402	24	diaz	diaz	PROPN
admet-831	402	25	-	-	PUNCT
admet-831	402	26	caballero	caballero	PROPN
admet-831	402	27	,	,	PUNCT
admet-831	402	28	j.	j.	PROPN
admet-831	402	29	lascorz	lascorz	PROPN
admet-831	402	30	,	,	PUNCT
admet-831	402	31	b.	b.	PROPN
admet-831	402	32	morel	morel	PROPN
admet-831	402	33	,	,	PUNCT
admet-831	402	34	s.	s.	PROPN
admet-831	402	35	navarro	navarro	PROPN
admet-831	402	36	,	,	PUNCT
admet-831	402	37	d.	d.	NOUN
admet-831	402	38	reverter	reverter	NOUN
admet-831	402	39	,	,	PUNCT
admet-831	402	40	s.	s.	PROPN
admet-831	402	41	kmiecik	kmiecik	PROPN
admet-831	402	42	,	,	PUNCT
admet-831	402	43	s.	s.	PROPN
admet-831	402	44	ventura	ventura	PROPN
admet-831	402	45	.	.	PUNCT
admet-831	403	1	combining	combine	VERB
admet-831	403	2	structural	structural	ADJ
admet-831	403	3	aggregation	aggregation	NOUN
admet-831	403	4	propensity	propensity	NOUN
admet-831	403	5	and	and	CCONJ
admet-831	403	6	stability	stability	NOUN
admet-831	403	7	predictions	prediction	NOUN
admet-831	403	8	to	to	PART
admet-831	403	9	redesign	redesign	VERB
admet-831	403	10	protein	protein	NOUN
admet-831	403	11	solubility	solubility	NOUN
admet-831	403	12	.	.	PUNCT
admet-831	404	1	mol	mol	PROPN
admet-831	404	2	.	.	PUNCT
admet-831	404	3	pharm	pharm	PROPN
admet-831	404	4	.	.	PUNCT
admet-831	405	1	15	15	NUM
admet-831	405	2	(	(	PUNCT
admet-831	405	3	2018	2018	NUM
admet-831	405	4	)	)	PUNCT
admet-831	405	5	3846	3846	NUM
admet-831	405	6	-	-	SYM
admet-831	405	7	3859	3859	NUM
admet-831	405	8	.	.	PUNCT
admet-831	406	1	[	[	X
admet-831	406	2	53	53	NUM
admet-831	406	3	]	]	X
admet-831	406	4	m.a	m.a	PROPN
admet-831	406	5	.	.	PROPN
admet-831	406	6	carballo	carballo	PROPN
admet-831	406	7	-	-	PUNCT
admet-831	406	8	amador	amador	PROPN
admet-831	406	9	,	,	PUNCT
admet-831	406	10	e.a	e.a	PROPN
admet-831	406	11	.	.	PROPN
admet-831	406	12	mckenzie	mckenzie	PROPN
admet-831	406	13	,	,	PUNCT
admet-831	406	14	a.j	a.j	PROPN
admet-831	406	15	.	.	PROPN
admet-831	406	16	dickson	dickson	PROPN
admet-831	406	17	,	,	PUNCT
admet-831	406	18	j.	j.	PROPN
admet-831	406	19	warwicker	warwicker	PROPN
admet-831	406	20	.	.	PUNCT
admet-831	406	21	surface	surface	NOUN
admet-831	406	22	patches	patch	NOUN
admet-831	406	23	on	on	ADP
admet-831	406	24	recombinant	recombinant	ADJ
admet-831	406	25	erythropoietin	erythropoietin	NOUN
admet-831	406	26	predict	predict	VERB
admet-831	406	27	protein	protein	NOUN
admet-831	406	28	solubility	solubility	NOUN
admet-831	406	29	:	:	PUNCT
admet-831	406	30	engineering	engineering	NOUN
admet-831	406	31	proteins	protein	NOUN
admet-831	406	32	to	to	ADP
admet-831	406	33	minimise	minimise	NOUN
admet-831	406	34	aggregation	aggregation	NOUN
admet-831	406	35	.	.	PUNCT
admet-831	407	1	bmc	bmc	PROPN
admet-831	407	2	biotechnol	biotechnol	NOUN
admet-831	407	3	.	.	PUNCT
admet-831	408	1	19	19	NUM
admet-831	408	2	(	(	PUNCT
admet-831	408	3	2019	2019	NUM
admet-831	408	4	)	)	PUNCT
admet-831	408	5	26	26	NUM
admet-831	408	6	.	.	PUNCT
admet-831	409	1	[	[	X
admet-831	409	2	54	54	NUM
admet-831	409	3	]	]	PUNCT
admet-831	409	4	s.	s.	PROPN
admet-831	409	5	navarro	navarro	PROPN
admet-831	409	6	,	,	PUNCT
admet-831	409	7	s.	s.	PROPN
admet-831	409	8	ventura	ventura	PROPN
admet-831	409	9	.	.	PUNCT
admet-831	410	1	computational	computational	PROPN
admet-831	410	2	re	re	NOUN
admet-831	410	3	-	-	NOUN
admet-831	410	4	design	design	NOUN
admet-831	410	5	of	of	ADP
admet-831	410	6	protein	protein	NOUN
admet-831	410	7	structures	structure	NOUN
admet-831	410	8	to	to	PART
admet-831	410	9	improve	improve	VERB
admet-831	410	10	solubility	solubility	NOUN
admet-831	410	11	.	.	PUNCT
admet-831	411	1	expert	expert	NOUN
admet-831	411	2	opin	opin	NOUN
admet-831	411	3	.	.	PUNCT
admet-831	412	1	drug	drug	NOUN
admet-831	412	2	discov	discov	NOUN
admet-831	412	3	.	.	PUNCT
admet-831	413	1	14	14	NUM
admet-831	413	2	(	(	PUNCT
admet-831	413	3	2019	2019	NUM
admet-831	413	4	)	)	PUNCT
admet-831	413	5	1077	1077	NUM
admet-831	413	6	-	-	SYM
admet-831	413	7	1088	1088	NUM
admet-831	413	8	.	.	PUNCT
admet-831	414	1	[	[	X
admet-831	414	2	55	55	NUM
admet-831	414	3	]	]	X
admet-831	414	4	n.	n.	PROPN
admet-831	414	5	chennamsetty	chennamsetty	PROPN
admet-831	414	6	,	,	PUNCT
admet-831	414	7	v.	v.	ADP
admet-831	414	8	voynov	voynov	NOUN
admet-831	414	9	,	,	PUNCT
admet-831	414	10	v.	v.	CCONJ
admet-831	414	11	kayser	kayser	PROPN
admet-831	414	12	,	,	PUNCT
admet-831	414	13	b.	b.	PROPN
admet-831	414	14	helk	helk	PROPN
admet-831	414	15	,	,	PUNCT
admet-831	414	16	b.l	b.l	PROPN
admet-831	414	17	.	.	PROPN
admet-831	414	18	trout	trout	NOUN
admet-831	414	19	.	.	PUNCT
admet-831	415	1	design	design	NOUN
admet-831	415	2	of	of	ADP
admet-831	415	3	therapeutic	therapeutic	ADJ
admet-831	415	4	proteins	protein	NOUN
admet-831	415	5	with	with	ADP
admet-831	415	6	enhanced	enhanced	ADJ
admet-831	415	7	stability	stability	NOUN
admet-831	415	8	.	.	PUNCT
admet-831	416	1	proc	proc	PROPN
admet-831	416	2	.	.	PUNCT
admet-831	417	1	natl	natl	PROPN
admet-831	417	2	.	.	PUNCT
admet-831	418	1	acad	acad	PROPN
admet-831	418	2	.	.	PUNCT
admet-831	419	1	sci	sci	PROPN
admet-831	419	2	.	.	PUNCT
admet-831	419	3	u.	u.	PROPN
admet-831	419	4	s.	s.	PROPN
admet-831	419	5	a.	a.	PROPN
admet-831	419	6	106	106	NUM
admet-831	419	7	(	(	PUNCT
admet-831	419	8	2009	2009	NUM
admet-831	419	9	)	)	PUNCT
admet-831	419	10	11937	11937	NUM
admet-831	419	11	-	-	SYM
admet-831	419	12	11942	11942	NUM
admet-831	419	13	.	.	PUNCT
admet-831	420	1	[	[	X
admet-831	420	2	56	56	NUM
admet-831	420	3	]	]	X
admet-831	420	4	j.r	j.r	PROPN
admet-831	420	5	.	.	PROPN
admet-831	420	6	klesmith	klesmith	PROPN
admet-831	420	7	,	,	PUNCT
admet-831	420	8	j.p	j.p	PROPN
admet-831	420	9	.	.	PROPN
admet-831	420	10	bacik	bacik	PROPN
admet-831	420	11	,	,	PUNCT
admet-831	420	12	e.e	e.e	PROPN
admet-831	420	13	.	.	PROPN
admet-831	420	14	wrenbeck	wrenbeck	PROPN
admet-831	420	15	,	,	PUNCT
admet-831	420	16	r.	r.	PROPN
admet-831	420	17	michalczyk	michalczyk	PROPN
admet-831	420	18	,	,	PUNCT
admet-831	420	19	t.a	t.a	PROPN
admet-831	420	20	.	.	PROPN
admet-831	420	21	whitehead	whitehead	PROPN
admet-831	420	22	.	.	PUNCT
admet-831	421	1	trade	trade	NOUN
admet-831	421	2	-	-	PUNCT
admet-831	421	3	offs	off	NOUN
admet-831	421	4	between	between	ADP
admet-831	421	5	enzyme	enzyme	NOUN
admet-831	421	6	fitness	fitness	NOUN
admet-831	421	7	and	and	CCONJ
admet-831	421	8	solubility	solubility	NOUN
admet-831	421	9	illuminated	illuminate	VERB
admet-831	421	10	by	by	ADP
admet-831	421	11	deep	deep	ADJ
admet-831	421	12	mutational	mutational	ADJ
admet-831	421	13	scanning	scanning	NOUN
admet-831	421	14	.	.	PUNCT
admet-831	422	1	proc	proc	NOUN
admet-831	422	2	.	.	PUNCT
admet-831	423	1	natl	natl	PROPN
admet-831	423	2	.	.	PUNCT
admet-831	424	1	acad	acad	PROPN
admet-831	424	2	.	.	PUNCT
admet-831	425	1	sci	sci	PROPN
admet-831	425	2	.	.	PUNCT
admet-831	425	3	u.	u.	PROPN
admet-831	425	4	s.	s.	PROPN
admet-831	425	5	a.	a.	PROPN
admet-831	425	6	114	114	NUM
admet-831	425	7	(	(	PUNCT
admet-831	425	8	2017	2017	NUM
admet-831	425	9	)	)	PUNCT
admet-831	425	10	2265	2265	NUM
admet-831	425	11	-	-	SYM
admet-831	425	12	2270	2270	NUM
admet-831	425	13	.	.	PUNCT
admet-831	426	1	©	©	PROPN
admet-831	426	2	2020	2020	NUM
admet-831	426	3	by	by	ADP
admet-831	426	4	the	the	DET
admet-831	426	5	authors	author	NOUN
admet-831	426	6	;	;	PUNCT
admet-831	426	7	licensee	licensee	PROPN
admet-831	426	8	iapc	iapc	PROPN
admet-831	426	9	,	,	PUNCT
admet-831	426	10	zagreb	zagreb	PROPN
admet-831	426	11	,	,	PUNCT
admet-831	426	12	croatia	croatia	PROPN
admet-831	426	13	.	.	PUNCT
admet-831	427	1	this	this	DET
admet-831	427	2	article	article	NOUN
admet-831	427	3	is	be	AUX
admet-831	427	4	an	an	DET
admet-831	427	5	open	open	ADJ
admet-831	427	6	-	-	PUNCT
admet-831	427	7	access	access	NOUN
admet-831	427	8	article	article	NOUN
admet-831	427	9	distributed	distribute	VERB
admet-831	427	10	under	under	ADP
admet-831	427	11	the	the	DET
admet-831	427	12	terms	term	NOUN
admet-831	427	13	and	and	CCONJ
admet-831	427	14	conditions	condition	NOUN
admet-831	427	15	of	of	ADP
admet-831	427	16	the	the	DET
admet-831	427	17	creative	creative	ADJ
admet-831	427	18	commons	common	NOUN
admet-831	427	19	attribution	attribution	NOUN
admet-831	427	20	license	license	NOUN
admet-831	427	21	(	(	PUNCT
admet-831	427	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-831	427	23	)	)	PUNCT
admet-831	427	24	http://dx.doi.org/10.5599/admet.831	http://dx.doi.org/10.5599/admet.831	PROPN
admet-831	427	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN