id	sid	tid	token	lemma	pos
admet-850	1	1	global	global	ADJ
admet-850	1	2	testing	testing	NOUN
admet-850	1	3	of	of	ADP
admet-850	1	4	a	a	DET
admet-850	1	5	consensus	consensus	NOUN
admet-850	1	6	solubility	solubility	NOUN
admet-850	1	7	assessment	assessment	NOUN
admet-850	1	8	to	to	PART
admet-850	1	9	enhance	enhance	VERB
admet-850	1	10	robustness	robustness	NOUN
admet-850	1	11	of	of	ADP
admet-850	1	12	the	the	DET
admet-850	1	13	who	who	PRON
admet-850	1	14	biopharmaceutical	biopharmaceutical	ADJ
admet-850	1	15	classification	classification	NOUN
admet-850	1	16	system	system	NOUN
admet-850	1	17	doi	doi	NOUN
admet-850	1	18	:	:	PUNCT
admet-850	1	19	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	NOUN
admet-850	1	20	23	23	NUM
admet-850	1	21	admet	admet	PROPN
admet-850	1	22	&	&	CCONJ
admet-850	1	23	dmpk	dmpk	PROPN
admet-850	1	24	9(1	9(1	NUM
admet-850	1	25	)	)	PUNCT
admet-850	1	26	(	(	PUNCT
admet-850	1	27	2021	2021	NUM
admet-850	1	28	)	)	PUNCT
admet-850	1	29	23	23	NUM
admet-850	1	30	-	-	SYM
admet-850	1	31	39	39	NUM
admet-850	1	32	;	;	PUNCT
admet-850	1	33	doi	doi	NOUN
admet-850	1	34	:	:	PUNCT
admet-850	1	35	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	X
admet-850	1	36	open	open	ADJ
admet-850	1	37	access	access	NOUN
admet-850	1	38	:	:	PUNCT
admet-850	1	39	issn	issn	PROPN
admet-850	1	40	:	:	PUNCT
admet-850	1	41	1848	1848	NUM
admet-850	1	42	-	-	SYM
admet-850	1	43	7718	7718	NUM
admet-850	1	44	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-850	1	45	original	original	ADJ
admet-850	1	46	scientific	scientific	ADJ
admet-850	1	47	article	article	NOUN
admet-850	1	48	global	global	ADJ
admet-850	1	49	testing	testing	NOUN
admet-850	1	50	of	of	ADP
admet-850	1	51	a	a	DET
admet-850	1	52	consensus	consensus	NOUN
admet-850	1	53	solubility	solubility	NOUN
admet-850	1	54	assessment	assessment	NOUN
admet-850	1	55	to	to	PART
admet-850	1	56	enhance	enhance	VERB
admet-850	1	57	robustness	robustness	NOUN
admet-850	1	58	of	of	ADP
admet-850	1	59	the	the	DET
admet-850	1	60	who	who	PRON
admet-850	1	61	biopharmaceutical	biopharmaceutical	ADJ
admet-850	1	62	classification	classification	NOUN
admet-850	1	63	system	system	NOUN
admet-850	1	64	valeria	valeria	PROPN
admet-850	1	65	gigante1	gigante1	PROPN
admet-850	1	66	,	,	PUNCT
admet-850	1	67	*	*	PROPN
admet-850	1	68	,	,	PUNCT
admet-850	1	69	giovanni	giovanni	PROPN
admet-850	1	70	m.	m.	PROPN
admet-850	1	71	pauletti2	pauletti2	PROPN
admet-850	1	72	,	,	PUNCT
admet-850	1	73	sabine	sabine	PROPN
admet-850	1	74	kopp1	kopp1	PROPN
admet-850	1	75	,	,	PUNCT
admet-850	1	76	minghze	minghze	PROPN
admet-850	1	77	xu3	xu3	PROPN
admet-850	1	78	,	,	PUNCT
admet-850	1	79	isabel	isabel	PROPN
admet-850	1	80	gonzalez	gonzalez	PROPN
admet-850	1	81	-	-	PUNCT
admet-850	1	82	alvarez10	alvarez10	NOUN
admet-850	1	83	,	,	PUNCT
admet-850	1	84	virginia	virginia	PROPN
admet-850	1	85	merino4	merino4	PROPN
admet-850	1	86	,	,	PUNCT
admet-850	1	87	michelle	michelle	PROPN
admet-850	1	88	p.	p.	PROPN
admet-850	1	89	mcintosh5	mcintosh5	PROPN
admet-850	1	90	,	,	PUNCT
admet-850	1	91	anita	anita	PROPN
admet-850	1	92	wessels6	wessels6	NOUN
admet-850	1	93	,	,	PUNCT
admet-850	1	94	beomjin	beomjin	NOUN
admet-850	1	95	lee7	lee7	PROPN
admet-850	1	96	,	,	PUNCT
admet-850	1	97	kênnia	kênnia	PROPN
admet-850	1	98	rocha	rocha	PROPN
admet-850	1	99	rezende8	rezende8	PROPN
admet-850	1	100	,	,	PUNCT
admet-850	1	101	gerhard	gerhard	PROPN
admet-850	1	102	k.e	k.e	PROPN
admet-850	1	103	.	.	PROPN
admet-850	1	104	scriba9	scriba9	PROPN
admet-850	1	105	,	,	PUNCT
admet-850	1	106	gaurav	gaurav	PROPN
admet-850	1	107	p.	p.	PROPN
admet-850	1	108	s.jadaun11	s.jadaun11	PROPN
admet-850	1	109	,	,	PUNCT
admet-850	1	110	marival	marival	NOUN
admet-850	1	111	bermejo10	bermejo10	VERB
admet-850	1	112	1	1	NUM
admet-850	1	113	norms	norm	NOUN
admet-850	1	114	and	and	CCONJ
admet-850	1	115	standards	standard	NOUN
admet-850	1	116	for	for	ADP
admet-850	1	117	pharmaceuticals	pharmaceutical	NOUN
admet-850	1	118	,	,	PUNCT
admet-850	1	119	world	world	NOUN
admet-850	1	120	health	health	NOUN
admet-850	1	121	organization	organization	PROPN
admet-850	1	122	,	,	PUNCT
admet-850	1	123	geneva	geneva	PROPN
admet-850	1	124	,	,	PUNCT
admet-850	1	125	switzerland	switzerland	PROPN
admet-850	1	126	;	;	PUNCT
admet-850	1	127	2	2	NUM
admet-850	1	128	department	department	NOUN
admet-850	1	129	of	of	ADP
admet-850	1	130	pharmaceutical	pharmaceutical	ADJ
admet-850	1	131	and	and	CCONJ
admet-850	1	132	administrative	administrative	ADJ
admet-850	1	133	sciences	sciences	PROPN
admet-850	1	134	,	,	PUNCT
admet-850	1	135	st	st	PROPN
admet-850	1	136	.	.	PROPN
admet-850	1	137	louis	louis	PROPN
admet-850	1	138	college	college	PROPN
admet-850	1	139	of	of	ADP
admet-850	1	140	pharmacy	pharmacy	PROPN
admet-850	1	141	,	,	PUNCT
admet-850	1	142	st	st	PROPN
admet-850	1	143	.	.	PROPN
admet-850	1	144	louis	louis	PROPN
admet-850	1	145	,	,	PUNCT
admet-850	1	146	missouri	missouri	PROPN
admet-850	1	147	,	,	PUNCT
admet-850	1	148	usa	usa	PROPN
admet-850	1	149	3	3	NUM
admet-850	1	150	institute	institute	PROPN
admet-850	1	151	for	for	ADP
admet-850	1	152	chemical	chemical	NOUN
admet-850	1	153	drug	drug	NOUN
admet-850	1	154	control	control	NOUN
admet-850	1	155	,	,	PUNCT
admet-850	1	156	china	china	PROPN
admet-850	1	157	national	national	PROPN
admet-850	1	158	institutes	institutes	PROPN
admet-850	1	159	for	for	ADP
admet-850	1	160	food	food	NOUN
admet-850	1	161	and	and	CCONJ
admet-850	1	162	drug	drug	NOUN
admet-850	1	163	control	control	NOUN
admet-850	1	164	,	,	PUNCT
admet-850	1	165	beijing	beijing	PROPN
admet-850	1	166	,	,	PUNCT
admet-850	1	167	china	china	PROPN
admet-850	1	168	4	4	NUM
admet-850	1	169	department	department	NOUN
admet-850	1	170	of	of	ADP
admet-850	1	171	pharmaceutics	pharmaceutic	NOUN
admet-850	1	172	and	and	CCONJ
admet-850	1	173	pharmaceutical	pharmaceutical	NOUN
admet-850	1	174	technology	technology	NOUN
admet-850	1	175	and	and	CCONJ
admet-850	1	176	parasitology	parasitology	NOUN
admet-850	1	177	,	,	PUNCT
admet-850	1	178	university	university	NOUN
admet-850	1	179	of	of	ADP
admet-850	1	180	valencia	valencia	PROPN
admet-850	1	181	,	,	PUNCT
admet-850	1	182	valencia	valencia	PROPN
admet-850	1	183	,	,	PUNCT
admet-850	1	184	spain	spain	PROPN
admet-850	1	185	5	5	NUM
admet-850	1	186	drug	drug	NOUN
admet-850	1	187	delivery	delivery	NOUN
admet-850	1	188	disposition	disposition	NOUN
admet-850	1	189	and	and	CCONJ
admet-850	1	190	dynamics	dynamic	NOUN
admet-850	1	191	,	,	PUNCT
admet-850	1	192	monash	monash	PROPN
admet-850	1	193	institute	institute	PROPN
admet-850	1	194	of	of	ADP
admet-850	1	195	pharmaceutical	pharmaceutical	PROPN
admet-850	1	196	sciences	sciences	PROPN
admet-850	1	197	,	,	PUNCT
admet-850	1	198	monash	monash	PROPN
admet-850	1	199	university	university	PROPN
admet-850	1	200	,	,	PUNCT
admet-850	1	201	parkville	parkville	PROPN
admet-850	1	202	,	,	PUNCT
admet-850	1	203	australia	australia	PROPN
admet-850	1	204	6	6	NUM
admet-850	1	205	north_west	north_w	ADJ
admet-850	1	206	university	university	NOUN
admet-850	1	207	,	,	PUNCT
admet-850	1	208	school	school	NOUN
admet-850	1	209	of	of	ADP
admet-850	1	210	pharmacy	pharmacy	NOUN
admet-850	1	211	,	,	PUNCT
admet-850	1	212	potchefstroom	potchefstroom	NOUN
admet-850	1	213	,	,	PUNCT
admet-850	1	214	south	south	PROPN
admet-850	1	215	africa	africa	PROPN
admet-850	1	216	7	7	NUM
admet-850	1	217	college	college	NOUN
admet-850	1	218	of	of	ADP
admet-850	1	219	pharmacy	pharmacy	NOUN
admet-850	1	220	and	and	CCONJ
admet-850	1	221	institute	institute	NOUN
admet-850	1	222	of	of	ADP
admet-850	1	223	pharmaceutical	pharmaceutical	NOUN
admet-850	1	224	science	science	NOUN
admet-850	1	225	and	and	CCONJ
admet-850	1	226	technology	technology	NOUN
admet-850	1	227	,	,	PUNCT
admet-850	1	228	ajou	ajou	VERB
admet-850	1	229	university	university	NOUN
admet-850	1	230	,	,	PUNCT
admet-850	1	231	suwon	suwon	PROPN
admet-850	1	232	,	,	PUNCT
admet-850	1	233	republic	republic	NOUN
admet-850	1	234	of	of	ADP
admet-850	1	235	korea	korea	PROPN
admet-850	1	236	8	8	NUM
admet-850	1	237	faculty	faculty	NOUN
admet-850	1	238	of	of	ADP
admet-850	1	239	pharmacy	pharmacy	NOUN
admet-850	1	240	,	,	PUNCT
admet-850	1	241	federal	federal	ADJ
admet-850	1	242	university	university	PROPN
admet-850	1	243	of	of	ADP
admet-850	1	244	goiás	goiás	NOUN
admet-850	1	245	,	,	PUNCT
admet-850	1	246	brazil	brazil	PROPN
admet-850	1	247	9	9	NUM
admet-850	1	248	department	department	NOUN
admet-850	1	249	of	of	ADP
admet-850	1	250	pharmaceutical	pharmaceutical	ADJ
admet-850	1	251	chemistry	chemistry	NOUN
admet-850	1	252	,	,	PUNCT
admet-850	1	253	friedrich	friedrich	PROPN
admet-850	1	254	schiller	schiller	PROPN
admet-850	1	255	-	-	PUNCT
admet-850	1	256	university	university	NOUN
admet-850	1	257	,	,	PUNCT
admet-850	1	258	jena	jena	PROPN
admet-850	1	259	,	,	PUNCT
admet-850	1	260	germany	germany	PROPN
admet-850	1	261	11	11	NUM
admet-850	1	262	indian	indian	PROPN
admet-850	1	263	pharmacopoeia	pharmacopoeia	PROPN
admet-850	1	264	commission	commission	PROPN
admet-850	1	265	,	,	PUNCT
admet-850	1	266	ministry	ministry	PROPN
admet-850	1	267	of	of	ADP
admet-850	1	268	health	health	PROPN
admet-850	1	269	&	&	CCONJ
admet-850	1	270	family	family	PROPN
admet-850	1	271	welfare	welfare	NOUN
admet-850	1	272	,	,	PUNCT
admet-850	1	273	govt	govt	NOUN
admet-850	1	274	.	.	PUNCT
admet-850	2	1	of	of	ADP
admet-850	2	2	india	india	PROPN
admet-850	2	3	,	,	PUNCT
admet-850	2	4	ghaziabad	ghaziabad	PROPN
admet-850	2	5	,	,	PUNCT
admet-850	2	6	india	india	PROPN
admet-850	2	7	10	10	NUM
admet-850	2	8	department	department	PROPN
admet-850	2	9	of	of	ADP
admet-850	2	10	engineering	engineering	NOUN
admet-850	2	11	:	:	PUNCT
admet-850	2	12	pharmacy	pharmacy	NOUN
admet-850	2	13	section	section	NOUN
admet-850	2	14	,	,	PUNCT
admet-850	2	15	universidad	universidad	PROPN
admet-850	2	16	miguel	miguel	PROPN
admet-850	2	17	hernández	hernández	PROPN
admet-850	2	18	de	de	PROPN
admet-850	2	19	elche	elche	PROPN
admet-850	2	20	,	,	PUNCT
admet-850	2	21	alicante	alicante	PROPN
admet-850	2	22	,	,	PUNCT
admet-850	2	23	spain	spain	PROPN
admet-850	2	24	*	*	PUNCT
admet-850	2	25	corresponding	correspond	VERB
admet-850	2	26	author	author	NOUN
admet-850	2	27	:	:	PUNCT
admet-850	2	28	e	e	NOUN
admet-850	2	29	-	-	NOUN
admet-850	2	30	mail	mail	NOUN
admet-850	2	31	:	:	PUNCT
admet-850	2	32	gigantev@who.int	gigantev@who.int	NOUN
admet-850	2	33	;	;	PUNCT
admet-850	2	34	tel	tel	PROPN
admet-850	2	35	.	.	PUNCT
admet-850	2	36	:	:	PUNCT
admet-850	3	1	+41(0)22	+41(0)22	ADJ
admet-850	3	2	-	-	SYM
admet-850	3	3	791	791	NUM
admet-850	3	4	4589	4589	NUM
admet-850	3	5	received	receive	VERB
admet-850	3	6	:	:	PUNCT
admet-850	3	7	may	may	AUX
admet-850	3	8	11	11	NUM
admet-850	3	9	,	,	PUNCT
admet-850	3	10	2020	2020	NUM
admet-850	3	11	;	;	PUNCT
admet-850	3	12	revised	revise	VERB
admet-850	3	13	:	:	PUNCT
admet-850	3	14	september	september	PROPN
admet-850	3	15	29	29	NUM
admet-850	3	16	,	,	PUNCT
admet-850	3	17	2020	2020	NUM
admet-850	3	18	;	;	PUNCT
admet-850	3	19	published	publish	VERB
admet-850	3	20	:	:	PUNCT
admet-850	3	21	october	october	PROPN
admet-850	3	22	07	07	NUM
admet-850	3	23	,	,	PUNCT
admet-850	3	24	2020	2020	NUM
admet-850	3	25	abstract	abstract	ADV
admet-850	3	26	the	the	PRON
admet-850	3	27	who	who	PRON
admet-850	3	28	biopharmaceutical	biopharmaceutical	ADJ
admet-850	3	29	classification	classification	NOUN
admet-850	3	30	system	system	NOUN
admet-850	3	31	(	(	PUNCT
admet-850	3	32	bcs	bcs	NOUN
admet-850	3	33	)	)	PUNCT
admet-850	3	34	is	be	AUX
admet-850	3	35	a	a	DET
admet-850	3	36	practical	practical	ADJ
admet-850	3	37	tool	tool	NOUN
admet-850	3	38	to	to	PART
admet-850	3	39	identify	identify	VERB
admet-850	3	40	active	active	ADJ
admet-850	3	41	pharmaceutical	pharmaceutical	ADJ
admet-850	3	42	ingredients	ingredient	NOUN
admet-850	3	43	(	(	PUNCT
admet-850	3	44	apis	apis	PROPN
admet-850	3	45	)	)	PUNCT
admet-850	3	46	that	that	PRON
admet-850	3	47	scientifically	scientifically	ADV
admet-850	3	48	qualify	qualify	VERB
admet-850	3	49	for	for	ADP
admet-850	3	50	a	a	DET
admet-850	3	51	waiver	waiver	NOUN
admet-850	3	52	of	of	ADP
admet-850	3	53	in	in	ADP
admet-850	3	54	vivo	vivo	ADJ
admet-850	3	55	bioequivalence	bioequivalence	NOUN
admet-850	3	56	studies	study	NOUN
admet-850	3	57	.	.	PUNCT
admet-850	4	1	the	the	DET
admet-850	4	2	focus	focus	NOUN
admet-850	4	3	of	of	ADP
admet-850	4	4	this	this	DET
admet-850	4	5	study	study	NOUN
admet-850	4	6	was	be	AUX
admet-850	4	7	to	to	PART
admet-850	4	8	engage	engage	VERB
admet-850	4	9	a	a	DET
admet-850	4	10	global	global	ADJ
admet-850	4	11	network	network	NOUN
admet-850	4	12	of	of	ADP
admet-850	4	13	laboratories	laboratory	NOUN
admet-850	4	14	to	to	PART
admet-850	4	15	experimentally	experimentally	ADV
admet-850	4	16	quantify	quantify	VERB
admet-850	4	17	the	the	DET
admet-850	4	18	ph	ph	ADJ
admet-850	4	19	-	-	ADJ
admet-850	4	20	dependent	dependent	ADJ
admet-850	4	21	solubility	solubility	NOUN
admet-850	4	22	of	of	ADP
admet-850	4	23	the	the	DET
admet-850	4	24	highest	high	ADJ
admet-850	4	25	therapeutic	therapeutic	ADJ
admet-850	4	26	dose	dose	NOUN
admet-850	4	27	of	of	ADP
admet-850	4	28	16	16	NUM
admet-850	4	29	apis	apis	ADJ
admet-850	4	30	using	use	VERB
admet-850	4	31	a	a	DET
admet-850	4	32	harmonized	harmonized	ADJ
admet-850	4	33	protocol	protocol	NOUN
admet-850	4	34	.	.	PUNCT
admet-850	5	1	intra	intra	ADJ
admet-850	5	2	-	-	ADJ
admet-850	5	3	laboratory	laboratory	ADJ
admet-850	5	4	variability	variability	NOUN
admet-850	5	5	was	be	AUX
admet-850	5	6	≤5	≤5	VERB
admet-850	5	7	%	%	NOUN
admet-850	5	8	,	,	PUNCT
admet-850	5	9	and	and	CCONJ
admet-850	5	10	no	no	DET
admet-850	5	11	apparent	apparent	ADJ
admet-850	5	12	association	association	NOUN
admet-850	5	13	of	of	ADP
admet-850	5	14	inter	inter	ADJ
admet-850	5	15	-	-	ADJ
admet-850	5	16	laboratory	laboratory	ADJ
admet-850	5	17	variability	variability	NOUN
admet-850	5	18	with	with	ADP
admet-850	5	19	api	api	NOUN
admet-850	5	20	solubility	solubility	NOUN
admet-850	5	21	was	be	AUX
admet-850	5	22	discovered	discover	VERB
admet-850	5	23	.	.	PUNCT
admet-850	6	1	final	final	ADJ
admet-850	6	2	classification	classification	NOUN
admet-850	6	3	“	"	PUNCT
admet-850	6	4	low	low	ADJ
admet-850	6	5	solubility	solubility	NOUN
admet-850	6	6	”	"	PUNCT
admet-850	6	7	vs	vs	ADP
admet-850	6	8	“	"	PUNCT
admet-850	6	9	high	high	ADJ
admet-850	6	10	solubility	solubility	NOUN
admet-850	6	11	”	"	PUNCT
admet-850	6	12	was	be	AUX
admet-850	6	13	consistent	consistent	ADJ
admet-850	6	14	among	among	ADP
admet-850	6	15	laboratories	laboratory	NOUN
admet-850	6	16	.	.	PUNCT
admet-850	7	1	in	in	ADP
admet-850	7	2	comparison	comparison	NOUN
admet-850	7	3	to	to	ADP
admet-850	7	4	the	the	DET
admet-850	7	5	literature	literature	NOUN
admet-850	7	6	-	-	PUNCT
admet-850	7	7	based	base	VERB
admet-850	7	8	provisional	provisional	ADJ
admet-850	7	9	2006	2006	NUM
admet-850	7	10	who	who	PRON
admet-850	7	11	bcs	bc	VERB
admet-850	7	12	classification	classification	NOUN
admet-850	7	13	,	,	PUNCT
admet-850	7	14	three	three	NUM
admet-850	7	15	compounds	compound	NOUN
admet-850	7	16	were	be	AUX
admet-850	7	17	reclassified	reclassify	VERB
admet-850	7	18	from	from	ADP
admet-850	7	19	“	"	PUNCT
admet-850	7	20	high	high	ADJ
admet-850	7	21	”	"	PUNCT
admet-850	7	22	to	to	ADP
admet-850	7	23	“	"	PUNCT
admet-850	7	24	low	low	ADJ
admet-850	7	25	-	-	PUNCT
admet-850	7	26	solubility	solubility	NOUN
admet-850	7	27	”	"	PUNCT
admet-850	7	28	.	.	PUNCT
admet-850	8	1	to	to	PART
admet-850	8	2	estimate	estimate	VERB
admet-850	8	3	the	the	DET
admet-850	8	4	consequences	consequence	NOUN
admet-850	8	5	of	of	ADP
admet-850	8	6	these	these	DET
admet-850	8	7	experimental	experimental	ADJ
admet-850	8	8	solubility	solubility	NOUN
admet-850	8	9	results	result	VERB
admet-850	8	10	on	on	ADP
admet-850	8	11	bcs	bcs	NOUN
admet-850	8	12	classification	classification	NOUN
admet-850	8	13	,	,	PUNCT
admet-850	8	14	dose	dose	NOUN
admet-850	8	15	-	-	PUNCT
admet-850	8	16	adjusted	adjust	VERB
admet-850	8	17	in	in	ADP
admet-850	8	18	silico	silico	NOUN
admet-850	8	19	predictions	prediction	NOUN
admet-850	8	20	of	of	ADP
admet-850	8	21	the	the	DET
admet-850	8	22	fraction	fraction	NOUN
admet-850	8	23	absorbed	absorb	VERB
admet-850	8	24	in	in	ADP
admet-850	8	25	humans	human	NOUN
admet-850	8	26	were	be	AUX
admet-850	8	27	performed	perform	VERB
admet-850	8	28	using	use	VERB
admet-850	8	29	gastroplus	gastroplus	ADJ
admet-850	8	30	®	®	NOUN
admet-850	8	31	.	.	PUNCT
admet-850	9	1	further	further	ADJ
admet-850	9	2	expansion	expansion	NOUN
admet-850	9	3	of	of	ADP
admet-850	9	4	these	these	DET
admet-850	9	5	experimental	experimental	ADJ
admet-850	9	6	efforts	effort	NOUN
admet-850	9	7	to	to	ADP
admet-850	9	8	qualified	qualified	ADJ
admet-850	9	9	apis	apis	PROPN
admet-850	9	10	from	from	ADP
admet-850	9	11	the	the	PRON
admet-850	9	12	who	who	PRON
admet-850	9	13	essential	essential	ADJ
admet-850	9	14	medicines	medicine	NOUN
admet-850	9	15	list	list	NOUN
admet-850	9	16	is	be	AUX
admet-850	9	17	anticipated	anticipate	VERB
admet-850	9	18	to	to	PART
admet-850	9	19	empower	empower	VERB
admet-850	9	20	regulatory	regulatory	ADJ
admet-850	9	21	authorities	authority	NOUN
admet-850	9	22	across	across	ADP
admet-850	9	23	the	the	DET
admet-850	9	24	globe	globe	NOUN
admet-850	9	25	to	to	PART
admet-850	9	26	issue	issue	VERB
admet-850	9	27	scientifically	scientifically	ADV
admet-850	9	28	-	-	PUNCT
admet-850	9	29	supported	support	VERB
admet-850	9	30	guidance	guidance	NOUN
admet-850	9	31	regarding	regard	VERB
admet-850	9	32	the	the	DET
admet-850	9	33	necessity	necessity	NOUN
admet-850	9	34	of	of	ADP
admet-850	9	35	performing	perform	VERB
admet-850	9	36	in	in	ADP
admet-850	9	37	vivo	vivo	ADJ
admet-850	9	38	bioequivalence	bioequivalence	NOUN
admet-850	9	39	studies	study	NOUN
admet-850	9	40	.	.	PUNCT
admet-850	10	1	ultimately	ultimately	ADV
admet-850	10	2	,	,	PUNCT
admet-850	10	3	this	this	PRON
admet-850	10	4	will	will	AUX
admet-850	10	5	improve	improve	VERB
admet-850	10	6	access	access	NOUN
admet-850	10	7	to	to	ADP
admet-850	10	8	affordable	affordable	ADJ
admet-850	10	9	generic	generic	ADJ
admet-850	10	10	products	product	NOUN
admet-850	10	11	,	,	PUNCT
admet-850	10	12	which	which	PRON
admet-850	10	13	is	be	AUX
admet-850	10	14	a	a	DET
admet-850	10	15	critical	critical	ADJ
admet-850	10	16	prerequisite	prerequisite	NOUN
admet-850	10	17	to	to	PART
admet-850	10	18	reach	reach	VERB
admet-850	10	19	universal	universal	ADJ
admet-850	10	20	health	health	NOUN
admet-850	10	21	coverage	coverage	NOUN
admet-850	10	22	.	.	PUNCT
admet-850	11	1	©	©	NOUN
admet-850	11	2	2021	2021	NUM
admet-850	11	3	by	by	ADP
admet-850	11	4	the	the	DET
admet-850	11	5	authors	author	NOUN
admet-850	11	6	.	.	PUNCT
admet-850	12	1	this	this	DET
admet-850	12	2	article	article	NOUN
admet-850	12	3	is	be	AUX
admet-850	12	4	an	an	DET
admet-850	12	5	open	open	ADJ
admet-850	12	6	-	-	PUNCT
admet-850	12	7	access	access	NOUN
admet-850	12	8	article	article	NOUN
admet-850	12	9	distributed	distribute	VERB
admet-850	12	10	under	under	ADP
admet-850	12	11	the	the	DET
admet-850	12	12	terms	term	NOUN
admet-850	12	13	and	and	CCONJ
admet-850	12	14	conditions	condition	NOUN
admet-850	12	15	of	of	ADP
admet-850	12	16	the	the	DET
admet-850	12	17	creative	creative	ADJ
admet-850	12	18	commons	common	NOUN
admet-850	12	19	attribution	attribution	NOUN
admet-850	12	20	license	license	NOUN
admet-850	12	21	(	(	PUNCT
admet-850	12	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-850	12	23	)	)	PUNCT
admet-850	12	24	.	.	PUNCT
admet-850	13	1	keywords	keyword	NOUN
admet-850	13	2	biowaiver	biowaiver	ADV
admet-850	13	3	;	;	PUNCT
admet-850	13	4	multisource	multisource	ADJ
admet-850	13	5	products	product	NOUN
admet-850	13	6	;	;	PUNCT
admet-850	13	7	essential	essential	ADJ
admet-850	13	8	medicines	medicine	NOUN
admet-850	13	9	;	;	PUNCT
admet-850	13	10	permeability	permeability	NOUN
admet-850	13	11	;	;	PUNCT
admet-850	13	12	regulatory	regulatory	ADJ
admet-850	13	13	guidance	guidance	NOUN
admet-850	13	14	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	13	15	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	14	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	AUX
admet-850	14	2	mailto:gigantev@who.int	mailto:gigantev@who.int	PROPN
admet-850	14	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-850	14	4	valeria	valeria	PROPN
admet-850	14	5	gigante	gigante	PROPN
admet-850	14	6	et	et	PROPN
admet-850	14	7	al	al	PROPN
admet-850	14	8	.	.	PROPN
admet-850	14	9	admet	admet	PROPN
admet-850	14	10	&	&	CCONJ
admet-850	14	11	dmpk	dmpk	PROPN
admet-850	14	12	9(1	9(1	NUM
admet-850	14	13	)	)	PUNCT
admet-850	14	14	(	(	PUNCT
admet-850	14	15	2021	2021	NUM
admet-850	14	16	)	)	PUNCT
admet-850	14	17	23	23	NUM
admet-850	14	18	-	-	SYM
admet-850	14	19	39	39	NUM
admet-850	14	20	24	24	NUM
admet-850	14	21	introduction	introduction	NOUN
admet-850	14	22	in	in	ADP
admet-850	14	23	a	a	DET
admet-850	14	24	world	world	NOUN
admet-850	14	25	where	where	SCONJ
admet-850	14	26	one	one	NUM
admet-850	14	27	third	third	NOUN
admet-850	14	28	of	of	ADP
admet-850	14	29	the	the	DET
admet-850	14	30	population	population	NOUN
admet-850	14	31	lacks	lack	VERB
admet-850	14	32	access	access	NOUN
admet-850	14	33	to	to	ADP
admet-850	14	34	essential	essential	ADJ
admet-850	14	35	medicines	medicine	NOUN
admet-850	14	36	[	[	X
admet-850	14	37	1	1	NUM
admet-850	14	38	]	]	PUNCT
admet-850	14	39	and	and	CCONJ
admet-850	14	40	medicines	medicine	NOUN
admet-850	14	41	represent	represent	VERB
admet-850	14	42	the	the	DET
admet-850	14	43	largest	large	ADJ
admet-850	14	44	family	family	NOUN
admet-850	14	45	expenditure	expenditure	NOUN
admet-850	14	46	after	after	ADP
admet-850	14	47	food	food	NOUN
admet-850	14	48	,	,	PUNCT
admet-850	14	49	generic	generic	ADJ
admet-850	14	50	competition	competition	NOUN
admet-850	14	51	and	and	CCONJ
admet-850	14	52	differential	differential	ADJ
admet-850	14	53	pricing	pricing	NOUN
admet-850	14	54	are	be	AUX
admet-850	14	55	major	major	ADJ
admet-850	14	56	drivers	driver	NOUN
admet-850	14	57	to	to	PART
admet-850	14	58	sustain	sustain	VERB
admet-850	14	59	a	a	DET
admet-850	14	60	healthy	healthy	ADJ
admet-850	14	61	population	population	NOUN
admet-850	14	62	,	,	PUNCT
admet-850	14	63	especially	especially	ADV
admet-850	14	64	in	in	ADP
admet-850	14	65	low	low	ADJ
admet-850	14	66	-	-	PUNCT
admet-850	14	67	income	income	NOUN
admet-850	14	68	countries	country	NOUN
admet-850	15	1	[	[	X
admet-850	15	2	2	2	NUM
admet-850	15	3	]	]	PUNCT
admet-850	15	4	.	.	PUNCT
admet-850	16	1	therefore	therefore	ADV
admet-850	16	2	,	,	PUNCT
admet-850	16	3	the	the	DET
admet-850	16	4	world	world	PROPN
admet-850	16	5	health	health	NOUN
admet-850	16	6	organization	organization	NOUN
admet-850	16	7	(	(	PUNCT
admet-850	16	8	who	who	PRON
admet-850	16	9	)	)	PUNCT
admet-850	16	10	has	have	AUX
admet-850	16	11	identified	identify	VERB
admet-850	16	12	access	access	NOUN
admet-850	16	13	to	to	ADP
admet-850	16	14	essential	essential	ADJ
admet-850	16	15	medicines	medicine	NOUN
admet-850	16	16	as	as	ADP
admet-850	16	17	one	one	NUM
admet-850	16	18	of	of	ADP
admet-850	16	19	its	its	PRON
admet-850	16	20	key	key	ADJ
admet-850	16	21	priorities	priority	NOUN
admet-850	16	22	to	to	PART
admet-850	16	23	meet	meet	VERB
admet-850	16	24	the	the	DET
admet-850	16	25	millennium	millennium	NOUN
admet-850	16	26	sustainable	sustainable	ADJ
admet-850	16	27	development	development	NOUN
admet-850	16	28	goals	goal	NOUN
admet-850	16	29	and	and	CCONJ
admet-850	16	30	reach	reach	VERB
admet-850	16	31	universal	universal	ADJ
admet-850	16	32	health	health	NOUN
admet-850	16	33	coverage	coverage	NOUN
admet-850	16	34	.	.	PUNCT
admet-850	17	1	in	in	ADP
admet-850	17	2	general	general	ADJ
admet-850	17	3	,	,	PUNCT
admet-850	17	4	regulatory	regulatory	ADJ
admet-850	17	5	agencies	agency	NOUN
admet-850	17	6	carry	carry	VERB
admet-850	17	7	the	the	DET
admet-850	17	8	public	public	ADJ
admet-850	17	9	health	health	NOUN
admet-850	17	10	responsibility	responsibility	NOUN
admet-850	17	11	to	to	PART
admet-850	17	12	carefully	carefully	ADV
admet-850	17	13	balance	balance	VERB
admet-850	17	14	access	access	NOUN
admet-850	17	15	to	to	ADP
admet-850	17	16	and	and	CCONJ
admet-850	17	17	safety	safety	NOUN
admet-850	17	18	of	of	ADP
admet-850	17	19	medicines	medicine	NOUN
admet-850	17	20	within	within	ADP
admet-850	17	21	their	their	PRON
admet-850	17	22	respective	respective	ADJ
admet-850	17	23	authorities	authority	NOUN
admet-850	17	24	.	.	PUNCT
admet-850	18	1	successful	successful	ADJ
admet-850	18	2	accomplishment	accomplishment	NOUN
admet-850	18	3	of	of	ADP
admet-850	18	4	this	this	DET
admet-850	18	5	objective	objective	NOUN
admet-850	18	6	requires	require	VERB
admet-850	18	7	risk	risk	NOUN
admet-850	18	8	management	management	NOUN
admet-850	18	9	strategies	strategy	NOUN
admet-850	18	10	that	that	PRON
admet-850	18	11	are	be	AUX
admet-850	18	12	based	base	VERB
admet-850	18	13	on	on	ADP
admet-850	18	14	scientifically	scientifically	ADV
admet-850	18	15	valid	valid	ADJ
admet-850	18	16	data	datum	NOUN
admet-850	18	17	.	.	PUNCT
admet-850	19	1	the	the	DET
admet-850	19	2	biopharmaceutical	biopharmaceutical	ADJ
admet-850	19	3	classification	classification	NOUN
admet-850	19	4	system	system	NOUN
admet-850	19	5	(	(	PUNCT
admet-850	19	6	bcs	bcs	NOUN
admet-850	19	7	)	)	PUNCT
admet-850	19	8	introduced	introduce	VERB
admet-850	19	9	in	in	ADP
admet-850	19	10	1995	1995	NUM
admet-850	19	11	[	[	X
admet-850	19	12	3	3	X
admet-850	19	13	]	]	PUNCT
admet-850	19	14	recognizes	recognize	VERB
admet-850	19	15	the	the	DET
admet-850	19	16	fundamental	fundamental	ADJ
admet-850	19	17	contribution	contribution	NOUN
admet-850	19	18	of	of	ADP
admet-850	19	19	aqueous	aqueous	ADJ
admet-850	19	20	solubility	solubility	NOUN
admet-850	19	21	of	of	ADP
admet-850	19	22	an	an	DET
admet-850	19	23	active	active	ADJ
admet-850	19	24	pharmaceutical	pharmaceutical	ADJ
admet-850	19	25	ingredient	ingredient	NOUN
admet-850	19	26	(	(	PUNCT
admet-850	19	27	api	api	NOUN
admet-850	19	28	)	)	PUNCT
admet-850	19	29	within	within	ADP
admet-850	19	30	the	the	DET
admet-850	19	31	physiologically	physiologically	ADV
admet-850	19	32	relevant	relevant	ADJ
admet-850	19	33	gastrointestinal	gastrointestinal	ADJ
admet-850	19	34	ph	ph	ADJ
admet-850	19	35	range	range	NOUN
admet-850	19	36	and	and	CCONJ
admet-850	19	37	its	its	PRON
admet-850	19	38	mucosal	mucosal	NOUN
admet-850	19	39	permeability	permeability	NOUN
admet-850	19	40	in	in	ADP
admet-850	19	41	governing	govern	VERB
admet-850	19	42	oral	oral	ADJ
admet-850	19	43	absorption	absorption	NOUN
admet-850	19	44	in	in	ADP
admet-850	19	45	vivo	vivo	NOUN
admet-850	19	46	.	.	PUNCT
admet-850	20	1	consequently	consequently	ADV
admet-850	20	2	,	,	PUNCT
admet-850	20	3	various	various	ADJ
admet-850	20	4	regulatory	regulatory	ADJ
admet-850	20	5	agencies	agency	NOUN
admet-850	20	6	around	around	ADP
admet-850	20	7	the	the	DET
admet-850	20	8	world	world	NOUN
admet-850	20	9	have	have	AUX
admet-850	20	10	adopted	adopt	VERB
admet-850	20	11	guidances	guidance	NOUN
admet-850	20	12	specifying	specify	VERB
admet-850	20	13	the	the	DET
admet-850	20	14	use	use	NOUN
admet-850	20	15	of	of	ADP
admet-850	20	16	the	the	DET
admet-850	20	17	bcs	bcs	NOUN
admet-850	20	18	as	as	ADP
admet-850	20	19	a	a	DET
admet-850	20	20	scientific	scientific	ADJ
admet-850	20	21	framework	framework	NOUN
admet-850	20	22	to	to	PART
admet-850	20	23	grant	grant	VERB
admet-850	20	24	a	a	DET
admet-850	20	25	waiver	waiver	NOUN
admet-850	20	26	of	of	ADP
admet-850	20	27	mandatory	mandatory	ADJ
admet-850	20	28	human	human	NOUN
admet-850	20	29	in	in	ADP
admet-850	20	30	vivo	vivo	ADJ
admet-850	20	31	bioequivalence	bioequivalence	NOUN
admet-850	20	32	studies	study	NOUN
admet-850	20	33	for	for	ADP
admet-850	20	34	immediate	immediate	ADJ
admet-850	20	35	-	-	PUNCT
admet-850	20	36	release	release	NOUN
admet-850	20	37	solid	solid	ADJ
admet-850	20	38	oral	oral	ADJ
admet-850	20	39	dosage	dosage	NOUN
admet-850	20	40	.	.	PUNCT
admet-850	21	1	hence	hence	ADV
admet-850	21	2	,	,	PUNCT
admet-850	21	3	qualifications	qualification	NOUN
admet-850	21	4	defined	define	VERB
admet-850	21	5	for	for	ADP
admet-850	21	6	a	a	DET
admet-850	21	7	biowaiver	biowaiver	NOUN
admet-850	21	8	directly	directly	ADV
admet-850	21	9	impact	impact	VERB
admet-850	21	10	access	access	NOUN
admet-850	21	11	to	to	ADP
admet-850	21	12	and	and	CCONJ
admet-850	21	13	affordability	affordability	NOUN
admet-850	21	14	of	of	ADP
admet-850	21	15	a	a	DET
admet-850	21	16	finished	finished	ADJ
admet-850	21	17	pharmaceutical	pharmaceutical	NOUN
admet-850	21	18	product	product	NOUN
admet-850	21	19	while	while	SCONJ
admet-850	21	20	assuring	assure	VERB
admet-850	21	21	the	the	DET
admet-850	21	22	quality	quality	NOUN
admet-850	21	23	of	of	ADP
admet-850	21	24	the	the	DET
admet-850	21	25	medicine	medicine	NOUN
admet-850	21	26	.	.	PUNCT
admet-850	22	1	the	the	PRON
admet-850	22	2	who	who	PRON
admet-850	22	3	recognizes	recognize	VERB
admet-850	22	4	the	the	DET
admet-850	22	5	possibility	possibility	NOUN
admet-850	22	6	of	of	ADP
admet-850	22	7	waiving	waive	VERB
admet-850	22	8	in	in	ADP
admet-850	22	9	vivo	vivo	ADJ
admet-850	22	10	bioequivalence	bioequivalence	NOUN
admet-850	22	11	studies	study	NOUN
admet-850	22	12	(	(	PUNCT
admet-850	22	13	i.e.	i.e.	X
admet-850	22	14	,	,	PUNCT
admet-850	22	15	biowaiver	biowaiver	NOUN
admet-850	22	16	)	)	PUNCT
admet-850	22	17	as	as	ADP
admet-850	22	18	an	an	DET
admet-850	22	19	effective	effective	ADJ
admet-850	22	20	regulatory	regulatory	ADJ
admet-850	22	21	strategy	strategy	NOUN
admet-850	22	22	to	to	PART
admet-850	22	23	accelerate	accelerate	VERB
admet-850	22	24	development	development	NOUN
admet-850	22	25	of	of	ADP
admet-850	22	26	generic	generic	ADJ
admet-850	22	27	products	product	NOUN
admet-850	22	28	for	for	ADP
admet-850	22	29	eligible	eligible	ADJ
admet-850	22	30	apis	apis	NOUN
admet-850	22	31	in	in	ADP
admet-850	22	32	order	order	NOUN
admet-850	22	33	to	to	PART
admet-850	22	34	improve	improve	VERB
admet-850	22	35	access	access	NOUN
admet-850	22	36	and	and	CCONJ
admet-850	22	37	save	save	VERB
admet-850	22	38	lives	life	NOUN
admet-850	22	39	.	.	PUNCT
admet-850	23	1	therefore	therefore	ADV
admet-850	23	2	,	,	PUNCT
admet-850	23	3	as	as	ADP
admet-850	23	4	part	part	NOUN
admet-850	23	5	of	of	ADP
admet-850	23	6	its	its	PRON
admet-850	23	7	2006	2006	NUM
admet-850	23	8	guidance	guidance	NOUN
admet-850	23	9	on	on	ADP
admet-850	23	10	waiving	waive	VERB
admet-850	23	11	of	of	ADP
admet-850	23	12	bioequivalence	bioequivalence	NOUN
admet-850	23	13	requirements	requirement	NOUN
admet-850	23	14	for	for	ADP
admet-850	23	15	immediate	immediate	ADJ
admet-850	23	16	-	-	PUNCT
admet-850	23	17	release	release	NOUN
admet-850	23	18	oral	oral	ADJ
admet-850	23	19	solid	solid	ADJ
admet-850	23	20	dosage	dosage	NOUN
admet-850	23	21	forms	form	NOUN
admet-850	23	22	,	,	PUNCT
admet-850	23	23	the	the	PRON
admet-850	23	24	who	who	PRON
admet-850	23	25	published	publish	VERB
admet-850	23	26	a	a	DET
admet-850	23	27	provisional	provisional	ADJ
admet-850	23	28	classification	classification	NOUN
admet-850	23	29	of	of	ADP
admet-850	23	30	apis	apis	PROPN
admet-850	23	31	based	base	VERB
admet-850	23	32	on	on	ADP
admet-850	23	33	the	the	DET
admet-850	23	34	14th	14th	ADJ
admet-850	23	35	who	who	PRON
admet-850	23	36	essential	essential	ADJ
admet-850	23	37	medicines	medicine	NOUN
admet-850	23	38	list	list	NOUN
admet-850	23	39	(	(	PUNCT
admet-850	23	40	eml	eml	PROPN
admet-850	23	41	)	)	PUNCT
admet-850	23	42	with	with	ADP
admet-850	23	43	regards	regard	NOUN
admet-850	23	44	to	to	ADP
admet-850	23	45	their	their	PRON
admet-850	23	46	eligibility	eligibility	NOUN
admet-850	23	47	for	for	ADP
admet-850	23	48	a	a	DET
admet-850	23	49	biowaiver	biowaiver	NOUN
admet-850	23	50	.	.	PUNCT
admet-850	24	1	as	as	SCONJ
admet-850	24	2	this	this	DET
admet-850	24	3	initial	initial	ADJ
admet-850	24	4	list	list	NOUN
admet-850	24	5	was	be	AUX
admet-850	24	6	largely	largely	ADV
admet-850	24	7	based	base	VERB
admet-850	24	8	on	on	ADP
admet-850	24	9	literature	literature	NOUN
admet-850	24	10	data	datum	NOUN
admet-850	24	11	,	,	PUNCT
admet-850	24	12	which	which	PRON
admet-850	24	13	can	can	AUX
admet-850	24	14	vary	vary	VERB
admet-850	24	15	widely	widely	ADV
admet-850	24	16	due	due	ADJ
admet-850	24	17	to	to	ADP
admet-850	24	18	different	different	ADJ
admet-850	24	19	experimental	experimental	ADJ
admet-850	24	20	conditions	condition	NOUN
admet-850	24	21	employed	employ	VERB
admet-850	24	22	,	,	PUNCT
admet-850	24	23	the	the	PRON
admet-850	24	24	who	who	PRON
admet-850	24	25	expert	expert	VERB
admet-850	24	26	committee	committee	NOUN
admet-850	24	27	on	on	ADP
admet-850	24	28	specifications	specification	NOUN
admet-850	24	29	for	for	ADP
admet-850	24	30	pharmaceutical	pharmaceutical	ADJ
admet-850	24	31	preparations	preparation	NOUN
admet-850	24	32	recommended	recommend	VERB
admet-850	24	33	in	in	ADP
admet-850	24	34	2016	2016	NUM
admet-850	24	35	that	that	SCONJ
admet-850	24	36	the	the	PRON
admet-850	24	37	who	who	PRON
admet-850	24	38	revises	revise	VERB
admet-850	24	39	this	this	DET
admet-850	24	40	list	list	NOUN
admet-850	24	41	to	to	ADP
admet-850	24	42	the	the	DET
admet-850	24	43	current	current	ADJ
admet-850	24	44	eml	eml	NOUN
admet-850	25	1	[	[	X
admet-850	25	2	4	4	NUM
admet-850	25	3	]	]	PUNCT
admet-850	25	4	using	use	VERB
admet-850	25	5	experimentally	experimentally	ADV
admet-850	25	6	determined	determine	VERB
admet-850	25	7	laboratory	laboratory	NOUN
admet-850	25	8	data	datum	NOUN
admet-850	25	9	according	accord	VERB
admet-850	25	10	to	to	ADP
admet-850	25	11	a	a	DET
admet-850	25	12	globally	globally	ADV
admet-850	25	13	harmonized	harmonize	VERB
admet-850	25	14	protocol	protocol	NOUN
admet-850	25	15	in	in	ADP
admet-850	25	16	order	order	NOUN
admet-850	25	17	to	to	PART
admet-850	25	18	facilitate	facilitate	VERB
admet-850	25	19	effective	effective	ADJ
admet-850	25	20	generic	generic	ADJ
admet-850	25	21	development	development	NOUN
admet-850	25	22	,	,	PUNCT
admet-850	25	23	including	include	VERB
admet-850	25	24	regulatory	regulatory	ADJ
admet-850	25	25	review	review	NOUN
admet-850	25	26	by	by	ADP
admet-850	25	27	national	national	ADJ
admet-850	25	28	regulatory	regulatory	ADJ
admet-850	25	29	authorities	authority	NOUN
admet-850	25	30	.	.	PUNCT
admet-850	26	1	the	the	DET
admet-850	26	2	primary	primary	ADJ
admet-850	26	3	objective	objective	NOUN
admet-850	26	4	of	of	ADP
admet-850	26	5	the	the	DET
admet-850	26	6	who	who	PRON
admet-850	26	7	biowaiver	biowaiver	NOUN
admet-850	26	8	guidance	guidance	NOUN
admet-850	26	9	is	be	AUX
admet-850	26	10	to	to	PART
admet-850	26	11	establish	establish	VERB
admet-850	26	12	a	a	DET
admet-850	26	13	scientific	scientific	ADJ
admet-850	26	14	framework	framework	NOUN
admet-850	26	15	whereby	whereby	SCONJ
admet-850	26	16	the	the	DET
admet-850	26	17	risk	risk	NOUN
admet-850	26	18	of	of	ADP
admet-850	26	19	bioinequivalence	bioinequivalence	NOUN
admet-850	26	20	is	be	AUX
admet-850	26	21	reduced	reduce	VERB
admet-850	26	22	to	to	ADP
admet-850	26	23	an	an	DET
admet-850	26	24	acceptable	acceptable	ADJ
admet-850	26	25	level	level	NOUN
admet-850	26	26	.	.	PUNCT
admet-850	27	1	leveraging	leverage	VERB
admet-850	27	2	an	an	DET
admet-850	27	3	api	api	NOUN
admet-850	27	4	’s	’s	PART
admet-850	27	5	main	main	ADJ
admet-850	27	6	physicochemical	physicochemical	ADJ
admet-850	27	7	characteristics	characteristic	NOUN
admet-850	27	8	that	that	PRON
admet-850	27	9	influence	influence	VERB
admet-850	27	10	intestinal	intestinal	ADJ
admet-850	27	11	absorption	absorption	NOUN
admet-850	27	12	,	,	PUNCT
admet-850	27	13	its	its	PRON
admet-850	27	14	clinical	clinical	ADJ
admet-850	27	15	safety	safety	NOUN
admet-850	27	16	and	and	CCONJ
admet-850	27	17	efficacy	efficacy	NOUN
admet-850	27	18	profile	profile	NOUN
admet-850	27	19	,	,	PUNCT
admet-850	27	20	and	and	CCONJ
admet-850	27	21	comparative	comparative	ADJ
admet-850	27	22	consideration	consideration	NOUN
admet-850	27	23	of	of	ADP
admet-850	27	24	the	the	DET
admet-850	27	25	finished	finish	VERB
admet-850	27	26	pharmaceutical	pharmaceutical	NOUN
admet-850	27	27	product	product	NOUN
admet-850	27	28	,	,	PUNCT
admet-850	27	29	it	it	PRON
admet-850	27	30	is	be	AUX
admet-850	27	31	accepted	accept	VERB
admet-850	27	32	that	that	SCONJ
admet-850	27	33	an	an	DET
admet-850	27	34	api	api	NOUN
admet-850	27	35	’s	’s	PART
admet-850	27	36	solubility	solubility	NOUN
admet-850	27	37	,	,	PUNCT
admet-850	27	38	permeability	permeability	NOUN
admet-850	27	39	,	,	PUNCT
admet-850	27	40	and	and	CCONJ
admet-850	27	41	comparative	comparative	ADJ
admet-850	27	42	dissolution	dissolution	NOUN
admet-850	27	43	data	datum	NOUN
admet-850	27	44	of	of	ADP
admet-850	27	45	the	the	DET
admet-850	27	46	finished	finish	VERB
admet-850	27	47	pharmaceutical	pharmaceutical	NOUN
admet-850	27	48	product	product	NOUN
admet-850	27	49	represent	represent	VERB
admet-850	27	50	adequate	adequate	ADJ
admet-850	27	51	scientific	scientific	ADJ
admet-850	27	52	evidence	evidence	NOUN
admet-850	27	53	to	to	PART
admet-850	27	54	enable	enable	VERB
admet-850	27	55	an	an	DET
admet-850	27	56	informed	informed	ADJ
admet-850	27	57	decision	decision	NOUN
admet-850	27	58	whether	whether	SCONJ
admet-850	27	59	or	or	CCONJ
admet-850	27	60	not	not	PART
admet-850	27	61	a	a	DET
admet-850	27	62	biowaiver	biowaiver	NOUN
admet-850	27	63	could	could	AUX
admet-850	27	64	be	be	AUX
admet-850	27	65	safely	safely	ADV
admet-850	27	66	recommended	recommend	VERB
admet-850	27	67	for	for	ADP
admet-850	27	68	a	a	DET
admet-850	27	69	specific	specific	ADJ
admet-850	27	70	api	api	NOUN
admet-850	27	71	.	.	PUNCT
admet-850	28	1	eligible	eligible	ADJ
admet-850	28	2	substances	substance	NOUN
admet-850	28	3	are	be	AUX
admet-850	28	4	those	those	PRON
admet-850	28	5	assigned	assign	VERB
admet-850	28	6	to	to	ADP
admet-850	28	7	class	class	NOUN
admet-850	28	8	i	i	NOUN
admet-850	28	9	(	(	PUNCT
admet-850	28	10	highly	highly	ADV
admet-850	28	11	soluble	soluble	ADJ
admet-850	28	12	and	and	CCONJ
admet-850	28	13	highly	highly	ADV
admet-850	28	14	permeable	permeable	ADJ
admet-850	28	15	)	)	PUNCT
admet-850	28	16	or	or	CCONJ
admet-850	28	17	class	class	NOUN
admet-850	28	18	iii	iii	PROPN
admet-850	28	19	(	(	PUNCT
admet-850	28	20	highly	highly	ADV
admet-850	28	21	soluble	soluble	ADJ
admet-850	28	22	and	and	CCONJ
admet-850	28	23	low	low	ADJ
admet-850	28	24	permeable	permeable	ADJ
admet-850	28	25	)	)	PUNCT
admet-850	28	26	according	accord	VERB
admet-850	28	27	to	to	ADP
admet-850	28	28	the	the	DET
admet-850	28	29	bsc	bsc	PROPN
admet-850	28	30	framework	framework	NOUN
admet-850	28	31	[	[	X
admet-850	28	32	5].the	5].the	DET
admet-850	28	33	bcs	bcs	NOUN
admet-850	28	34	is	be	AUX
admet-850	28	35	widely	widely	ADV
admet-850	28	36	accepted	accept	VERB
admet-850	28	37	by	by	ADP
admet-850	28	38	various	various	ADJ
admet-850	28	39	regulatory	regulatory	ADJ
admet-850	28	40	authority	authority	NOUN
admet-850	28	41	,	,	PUNCT
admet-850	28	42	including	include	VERB
admet-850	28	43	ema	ema	PROPN
admet-850	28	44	and	and	CCONJ
admet-850	28	45	fda	fda	PROPN
admet-850	28	46	,	,	PUNCT
admet-850	28	47	and	and	CCONJ
admet-850	28	48	highlights	highlight	VERB
admet-850	28	49	the	the	DET
admet-850	28	50	pivotal	pivotal	ADJ
admet-850	28	51	role	role	NOUN
admet-850	28	52	of	of	ADP
admet-850	28	53	solubility	solubility	NOUN
admet-850	28	54	underpinning	underpin	VERB
admet-850	28	55	the	the	DET
admet-850	28	56	biowaiver	biowaiver	PROPN
admet-850	28	57	approach	approach	NOUN
admet-850	28	58	.	.	PUNCT
admet-850	29	1	according	accord	VERB
admet-850	29	2	to	to	ADP
admet-850	29	3	the	the	PRON
admet-850	29	4	who	who	PRON
admet-850	29	5	,	,	PUNCT
admet-850	29	6	an	an	DET
admet-850	29	7	api	api	NOUN
admet-850	29	8	is	be	AUX
admet-850	29	9	considered	consider	VERB
admet-850	29	10	highly	highly	ADV
admet-850	29	11	soluble	soluble	ADJ
admet-850	29	12	when	when	SCONJ
admet-850	29	13	the	the	DET
admet-850	29	14	highest	high	ADJ
admet-850	29	15	single	single	ADJ
admet-850	29	16	therapeutic	therapeutic	ADJ
admet-850	29	17	dose	dose	NOUN
admet-850	29	18	(	(	PUNCT
admet-850	29	19	e.g.	e.g.	ADV
admet-850	29	20	,	,	PUNCT
admet-850	29	21	the	the	DET
admet-850	29	22	maximum	maximum	PROPN
admet-850	29	23	dose	dose	NOUN
admet-850	29	24	administered	administer	VERB
admet-850	29	25	orally	orally	ADV
admet-850	29	26	at	at	ADP
admet-850	29	27	once	once	ADV
admet-850	29	28	)	)	PUNCT
admet-850	29	29	as	as	SCONJ
admet-850	29	30	specified	specify	VERB
admet-850	29	31	in	in	ADP
admet-850	29	32	the	the	DET
admet-850	29	33	approved	approve	VERB
admet-850	29	34	product	product	NOUN
admet-850	29	35	label	label	NOUN
admet-850	29	36	of	of	ADP
admet-850	29	37	the	the	DET
admet-850	29	38	originator	originator	NOUN
admet-850	29	39	is	be	AUX
admet-850	29	40	soluble	soluble	ADJ
admet-850	29	41	in	in	ADP
admet-850	29	42	250	250	NUM
admet-850	29	43	ml	ml	NOUN
admet-850	29	44	or	or	CCONJ
admet-850	29	45	less	less	ADJ
admet-850	29	46	of	of	ADP
admet-850	29	47	aqueous	aqueous	ADJ
admet-850	29	48	media	medium	NOUN
admet-850	29	49	over	over	ADP
admet-850	29	50	the	the	DET
admet-850	29	51	ph	ph	ADJ
admet-850	29	52	range	range	NOUN
admet-850	29	53	of	of	ADP
admet-850	29	54	1.2–6.8	1.2–6.8	NOUN
admet-850	30	1	[	[	X
admet-850	30	2	6	6	NUM
admet-850	30	3	]	]	PUNCT
admet-850	30	4	.	.	PUNCT
admet-850	31	1	comparative	comparative	ADJ
admet-850	31	2	dissolution	dissolution	PROPN
admet-850	31	3	data	datum	NOUN
admet-850	31	4	are	be	AUX
admet-850	31	5	expected	expect	VERB
admet-850	31	6	to	to	PART
admet-850	31	7	be	be	AUX
admet-850	31	8	generated	generate	VERB
admet-850	31	9	by	by	ADP
admet-850	31	10	pharmaceutical	pharmaceutical	ADJ
admet-850	31	11	manufactures	manufacture	NOUN
admet-850	31	12	for	for	ADP
admet-850	31	13	eligible	eligible	ADJ
admet-850	31	14	finished	finish	VERB
admet-850	31	15	pharmaceutical	pharmaceutical	NOUN
admet-850	31	16	product	product	NOUN
admet-850	31	17	containing	contain	VERB
admet-850	31	18	the	the	DET
admet-850	31	19	apis	apis	NOUN
admet-850	31	20	classified	classify	VERB
admet-850	31	21	within	within	ADP
admet-850	31	22	this	this	DET
admet-850	31	23	research	research	NOUN
admet-850	31	24	project	project	NOUN
admet-850	31	25	.	.	PUNCT
admet-850	32	1	regulators	regulator	NOUN
admet-850	32	2	will	will	AUX
admet-850	32	3	assess	assess	VERB
admet-850	32	4	the	the	DET
admet-850	32	5	similarity	similarity	NOUN
admet-850	32	6	in	in	ADP
admet-850	32	7	the	the	DET
admet-850	32	8	dissolution	dissolution	NOUN
admet-850	32	9	profiles	profile	NOUN
admet-850	32	10	generated	generate	VERB
admet-850	32	11	in	in	ADP
admet-850	32	12	order	order	NOUN
admet-850	32	13	to	to	PART
admet-850	32	14	evaluate	evaluate	VERB
admet-850	32	15	a	a	DET
admet-850	32	16	potential	potential	ADJ
admet-850	32	17	waiver	waiver	NOUN
admet-850	32	18	from	from	ADP
admet-850	32	19	in	in	ADP
admet-850	32	20	vivo	vivo	NOUN
admet-850	32	21	be	be	VERB
admet-850	32	22	studies	study	NOUN
admet-850	32	23	.	.	PUNCT
admet-850	33	1	following	follow	VERB
admet-850	33	2	a	a	DET
admet-850	33	3	recommendation	recommendation	NOUN
admet-850	33	4	from	from	ADP
admet-850	33	5	the	the	DET
admet-850	33	6	who	who	PRON
admet-850	33	7	expert	expert	ADJ
admet-850	33	8	committee	committee	NOUN
admet-850	33	9	on	on	ADP
admet-850	33	10	specifications	specification	NOUN
admet-850	33	11	for	for	ADP
admet-850	33	12	pharmaceutical	pharmaceutical	NOUN
admet-850	33	13	admet	admet	PROPN
admet-850	33	14	&	&	CCONJ
admet-850	33	15	dmpk	dmpk	PROPN
admet-850	33	16	9(1	9(1	NUM
admet-850	33	17	)	)	PUNCT
admet-850	33	18	(	(	PUNCT
admet-850	33	19	2021	2021	NUM
admet-850	33	20	)	)	PUNCT
admet-850	33	21	23	23	NUM
admet-850	33	22	-	-	SYM
admet-850	33	23	39	39	NUM
admet-850	33	24	enhancing	enhance	VERB
admet-850	33	25	robustness	robustness	NOUN
admet-850	33	26	of	of	ADP
admet-850	33	27	the	the	PRON
admet-850	33	28	who	who	PRON
admet-850	33	29	biopharmaceutical	biopharmaceutical	ADJ
admet-850	33	30	classification	classification	NOUN
admet-850	33	31	system	system	NOUN
admet-850	33	32	doi	doi	NOUN
admet-850	33	33	:	:	PUNCT
admet-850	33	34	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	AUX
admet-850	33	35	25	25	NUM
admet-850	33	36	preparations	preparation	NOUN
admet-850	33	37	,	,	PUNCT
admet-850	33	38	the	the	PRON
admet-850	33	39	who	who	PRON
admet-850	33	40	norms	norm	VERB
admet-850	33	41	and	and	CCONJ
admet-850	33	42	standards	standard	NOUN
admet-850	33	43	for	for	ADP
admet-850	33	44	pharmaceuticals	pharmaceutical	NOUN
admet-850	33	45	team	team	NOUN
admet-850	33	46	initiated	initiate	VERB
admet-850	33	47	in	in	ADP
admet-850	33	48	2017	2017	NUM
admet-850	34	1	the	the	DET
admet-850	34	2	who	who	PRON
admet-850	34	3	biowaiver	biowaiver	PROPN
admet-850	34	4	project	project	NOUN
admet-850	34	5	aimed	aim	VERB
admet-850	34	6	at	at	ADP
admet-850	34	7	revising	revise	VERB
admet-850	34	8	its	its	PRON
admet-850	34	9	2006	2006	NUM
admet-850	34	10	bcs	bcs	NOUN
admet-850	34	11	[	[	X
admet-850	34	12	6	6	NUM
admet-850	34	13	]	]	PUNCT
admet-850	34	14	.	.	PUNCT
admet-850	35	1	to	to	PART
admet-850	35	2	support	support	VERB
admet-850	35	3	revision	revision	NOUN
admet-850	35	4	of	of	ADP
admet-850	35	5	this	this	DET
admet-850	35	6	provisional	provisional	ADJ
admet-850	35	7	classification	classification	NOUN
admet-850	35	8	list	list	NOUN
admet-850	35	9	,	,	PUNCT
admet-850	35	10	which	which	PRON
admet-850	35	11	was	be	AUX
admet-850	35	12	largely	largely	ADV
admet-850	35	13	based	base	VERB
admet-850	35	14	on	on	ADP
admet-850	35	15	secondary	secondary	ADJ
admet-850	35	16	aqueous	aqueous	ADJ
admet-850	35	17	solubility	solubility	NOUN
admet-850	35	18	references	reference	NOUN
admet-850	35	19	and	and	CCONJ
admet-850	35	20	a	a	DET
admet-850	35	21	diverse	diverse	ADJ
admet-850	35	22	array	array	NOUN
admet-850	35	23	of	of	ADP
admet-850	35	24	permeability	permeability	NOUN
admet-850	35	25	data	datum	NOUN
admet-850	35	26	published	publish	VERB
admet-850	35	27	in	in	ADP
admet-850	35	28	the	the	DET
admet-850	35	29	literature	literature	NOUN
admet-850	35	30	,	,	PUNCT
admet-850	35	31	a	a	DET
admet-850	35	32	global	global	ADJ
admet-850	35	33	multi	multi	ADJ
admet-850	35	34	-	-	ADJ
admet-850	35	35	center	center	ADJ
admet-850	35	36	research	research	NOUN
admet-850	35	37	team	team	NOUN
admet-850	35	38	was	be	AUX
admet-850	35	39	assembled	assemble	VERB
admet-850	35	40	and	and	CCONJ
admet-850	35	41	tasked	task	VERB
admet-850	35	42	to	to	PART
admet-850	35	43	study	study	VERB
admet-850	35	44	solubility	solubility	NOUN
admet-850	35	45	profiles	profile	NOUN
admet-850	35	46	of	of	ADP
admet-850	35	47	selected	select	VERB
admet-850	35	48	apis	apis	PROPN
admet-850	35	49	using	use	VERB
admet-850	35	50	a	a	DET
admet-850	35	51	harmonized	harmonized	ADJ
admet-850	35	52	experimental	experimental	ADJ
admet-850	35	53	protocol	protocol	NOUN
admet-850	35	54	.	.	PUNCT
admet-850	36	1	the	the	DET
admet-850	36	2	project	project	NOUN
admet-850	36	3	began	begin	VERB
admet-850	36	4	in	in	ADP
admet-850	36	5	2018	2018	NUM
admet-850	36	6	as	as	ADP
admet-850	36	7	a	a	DET
admet-850	36	8	small	small	ADJ
admet-850	36	9	-	-	PUNCT
admet-850	36	10	scale	scale	NOUN
admet-850	36	11	pilot	pilot	NOUN
admet-850	36	12	(	(	PUNCT
admet-850	36	13	cycle	cycle	NOUN
admet-850	36	14	i	i	PROPN
admet-850	36	15	)	)	PUNCT
admet-850	36	16	focusing	focus	VERB
admet-850	36	17	on	on	ADP
admet-850	36	18	the	the	DET
admet-850	36	19	development	development	NOUN
admet-850	36	20	of	of	ADP
admet-850	36	21	a	a	DET
admet-850	36	22	universal	universal	ADJ
admet-850	36	23	,	,	PUNCT
admet-850	36	24	scientifically	scientifically	ADV
admet-850	36	25	sound	sound	ADJ
admet-850	36	26	methodology	methodology	NOUN
admet-850	36	27	to	to	PART
admet-850	36	28	consistently	consistently	ADV
admet-850	36	29	assess	assess	VERB
admet-850	36	30	an	an	DET
admet-850	36	31	api	api	NOUN
admet-850	36	32	’s	’s	PART
admet-850	36	33	solubility	solubility	NOUN
admet-850	36	34	within	within	ADP
admet-850	36	35	the	the	DET
admet-850	36	36	desired	desire	VERB
admet-850	36	37	gastrointestinal	gastrointestinal	ADJ
admet-850	36	38	ph	ph	ADJ
admet-850	36	39	range	range	NOUN
admet-850	36	40	of	of	ADP
admet-850	36	41	1.2–6.8	1.2–6.8	NUM
admet-850	36	42	.	.	PUNCT
admet-850	37	1	preliminary	preliminary	ADJ
admet-850	37	2	validation	validation	NOUN
admet-850	37	3	of	of	ADP
admet-850	37	4	the	the	DET
admet-850	37	5	refined	refined	ADJ
admet-850	37	6	equilibrium	equilibrium	NOUN
admet-850	37	7	solubility	solubility	NOUN
admet-850	37	8	protocol	protocol	NOUN
admet-850	37	9	was	be	AUX
admet-850	37	10	performed	perform	VERB
admet-850	37	11	by	by	ADP
admet-850	37	12	three	three	NUM
admet-850	37	13	independent	independent	ADJ
admet-850	37	14	laboratories	laboratory	NOUN
admet-850	37	15	and	and	CCONJ
admet-850	37	16	details	detail	NOUN
admet-850	37	17	of	of	ADP
admet-850	37	18	the	the	DET
admet-850	37	19	procedure	procedure	NOUN
admet-850	37	20	were	be	AUX
admet-850	37	21	published	publish	VERB
admet-850	37	22	as	as	ADP
admet-850	37	23	the	the	DET
admet-850	37	24	“	"	PUNCT
admet-850	37	25	who	who	PRON
admet-850	37	26	protocol	protocol	VERB
admet-850	37	27	to	to	PART
admet-850	37	28	conduct	conduct	VERB
admet-850	37	29	equilibrium	equilibrium	NOUN
admet-850	37	30	solubility	solubility	NOUN
admet-850	37	31	experiments	experiment	NOUN
admet-850	37	32	for	for	ADP
admet-850	37	33	the	the	DET
admet-850	37	34	purpose	purpose	NOUN
admet-850	37	35	of	of	ADP
admet-850	37	36	biopharmaceutics	biopharmaceutics	NOUN
admet-850	37	37	classification	classification	NOUN
admet-850	37	38	system	system	NOUN
admet-850	37	39	-	-	PUNCT
admet-850	37	40	based	base	VERB
admet-850	37	41	classification	classification	NOUN
admet-850	37	42	of	of	ADP
admet-850	37	43	active	active	ADJ
admet-850	37	44	pharmaceutical	pharmaceutical	ADJ
admet-850	37	45	ingredients	ingredient	NOUN
admet-850	37	46	for	for	ADP
admet-850	37	47	biowaiver	biowaiver	NOUN
admet-850	37	48	”	"	PUNCT
admet-850	37	49	,	,	PUNCT
admet-850	37	50	hereinafter	hereinafter	NOUN
admet-850	37	51	referred	refer	VERB
admet-850	37	52	as	as	ADP
admet-850	37	53	the	the	DET
admet-850	37	54	protocol	protocol	NOUN
admet-850	37	55	.	.	PUNCT
admet-850	38	1	to	to	PART
admet-850	38	2	prioritize	prioritize	VERB
admet-850	38	3	apis	apis	PROPN
admet-850	38	4	for	for	ADP
admet-850	38	5	the	the	DET
admet-850	38	6	second	second	ADJ
admet-850	38	7	phase	phase	NOUN
admet-850	38	8	of	of	ADP
admet-850	38	9	the	the	DET
admet-850	38	10	project	project	NOUN
admet-850	38	11	(	(	PUNCT
admet-850	38	12	cycle	cycle	NOUN
admet-850	38	13	ii	ii	PROPN
admet-850	38	14	)	)	PUNCT
admet-850	38	15	,	,	PUNCT
admet-850	38	16	which	which	PRON
admet-850	38	17	was	be	AUX
admet-850	38	18	intended	intend	VERB
admet-850	38	19	to	to	PART
admet-850	38	20	compare	compare	VERB
admet-850	38	21	inter	inter	ADJ
admet-850	38	22	-	-	ADJ
admet-850	38	23	laboratory	laboratory	ADJ
admet-850	38	24	variability	variability	NOUN
admet-850	38	25	on	on	ADP
admet-850	38	26	api	api	NOUN
admet-850	38	27	solubility	solubility	NOUN
admet-850	38	28	assessment	assessment	NOUN
admet-850	38	29	and	and	CCONJ
admet-850	38	30	classification	classification	NOUN
admet-850	38	31	using	use	VERB
admet-850	38	32	the	the	DET
admet-850	38	33	globally	globally	ADV
admet-850	38	34	harmonized	harmonized	ADJ
admet-850	38	35	protocol	protocol	NOUN
admet-850	38	36	,	,	PUNCT
admet-850	38	37	the	the	DET
admet-850	38	38	following	follow	VERB
admet-850	38	39	selection	selection	NOUN
admet-850	38	40	criteria	criterion	NOUN
admet-850	38	41	were	be	AUX
admet-850	38	42	defined	define	VERB
admet-850	38	43	[	[	PUNCT
admet-850	38	44	7	7	NUM
admet-850	38	45	]	]	SYM
admet-850	38	46	:	:	PUNCT
admet-850	38	47	i	i	NOUN
admet-850	38	48	)	)	PUNCT
admet-850	38	49	api	api	NOUN
admet-850	38	50	included	include	VERB
admet-850	38	51	in	in	ADP
admet-850	38	52	medicines	medicine	NOUN
admet-850	38	53	listed	list	VERB
admet-850	38	54	on	on	ADP
admet-850	38	55	the	the	DET
admet-850	38	56	eml	eml	PROPN
admet-850	38	57	;	;	PUNCT
admet-850	38	58	ii	ii	PROPN
admet-850	38	59	)	)	PUNCT
admet-850	38	60	intended	intend	VERB
admet-850	38	61	to	to	PART
admet-850	38	62	be	be	AUX
admet-850	38	63	formulated	formulate	VERB
admet-850	38	64	as	as	ADP
admet-850	38	65	immediate	immediate	ADJ
admet-850	38	66	-	-	PUNCT
admet-850	38	67	release	release	NOUN
admet-850	38	68	,	,	PUNCT
admet-850	38	69	solid	solid	ADJ
admet-850	38	70	oral	oral	ADJ
admet-850	38	71	dosage	dosage	NOUN
admet-850	38	72	forms	form	NOUN
admet-850	38	73	;	;	PUNCT
admet-850	38	74	iii	iii	X
admet-850	38	75	)	)	PUNCT
admet-850	38	76	relevant	relevant	ADJ
admet-850	38	77	to	to	ADP
admet-850	38	78	therapeutic	therapeutic	ADJ
admet-850	38	79	areas	area	NOUN
admet-850	38	80	of	of	ADP
admet-850	38	81	major	major	ADJ
admet-850	38	82	public	public	ADJ
admet-850	38	83	interest	interest	NOUN
admet-850	38	84	;	;	PUNCT
admet-850	38	85	and	and	CCONJ
admet-850	38	86	iv	iv	X
admet-850	38	87	)	)	PUNCT
admet-850	38	88	exhibiting	exhibit	VERB
admet-850	38	89	well	well	ADV
admet-850	38	90	-	-	PUNCT
admet-850	38	91	characterized	characterize	VERB
admet-850	38	92	physicochemical	physicochemical	ADJ
admet-850	38	93	properties	property	NOUN
admet-850	38	94	.	.	PUNCT
admet-850	39	1	pharmaceuticals	pharmaceutical	NOUN
admet-850	39	2	of	of	ADP
admet-850	39	3	primary	primary	ADJ
admet-850	39	4	interest	interest	NOUN
admet-850	39	5	to	to	ADP
admet-850	39	6	the	the	PRON
admet-850	39	7	who	who	PRON
admet-850	39	8	are	be	AUX
admet-850	39	9	those	those	PRON
admet-850	39	10	associated	associate	VERB
admet-850	39	11	with	with	ADP
admet-850	39	12	who	who	PRON
admet-850	39	13	programs	program	NOUN
admet-850	39	14	focusing	focus	VERB
admet-850	39	15	on	on	ADP
admet-850	39	16	non	non	ADJ
admet-850	39	17	-	-	ADJ
admet-850	39	18	communicable	communicable	ADJ
admet-850	39	19	diseases	disease	NOUN
admet-850	39	20	,	,	PUNCT
admet-850	39	21	neglected	neglect	VERB
admet-850	39	22	tropical	tropical	ADJ
admet-850	39	23	diseases	disease	NOUN
admet-850	39	24	,	,	PUNCT
admet-850	39	25	and	and	CCONJ
admet-850	39	26	maternal	maternal	ADJ
admet-850	39	27	-	-	PUNCT
admet-850	39	28	child	child	NOUN
admet-850	39	29	health	health	NOUN
admet-850	39	30	,	,	PUNCT
admet-850	39	31	including	include	VERB
admet-850	39	32	tuberculosis	tuberculosis	NOUN
admet-850	39	33	,	,	PUNCT
admet-850	39	34	malaria	malaria	NOUN
admet-850	39	35	,	,	PUNCT
admet-850	39	36	and	and	CCONJ
admet-850	39	37	hiv	hiv	PROPN
admet-850	39	38	/	/	SYM
admet-850	39	39	aids	aids	PROPN
admet-850	39	40	.	.	PUNCT
admet-850	40	1	candidate	candidate	NOUN
admet-850	40	2	apis	api	VERB
admet-850	40	3	for	for	ADP
admet-850	40	4	cycle	cycle	NOUN
admet-850	40	5	ii	ii	PROPN
admet-850	40	6	of	of	ADP
admet-850	40	7	the	the	PRON
admet-850	40	8	who	who	PRON
admet-850	40	9	biowaiver	biowaiver	PROPN
admet-850	40	10	project	project	NOUN
admet-850	40	11	were	be	AUX
admet-850	40	12	identified	identify	VERB
admet-850	40	13	through	through	ADP
admet-850	40	14	a	a	DET
admet-850	40	15	prioritization	prioritization	NOUN
admet-850	40	16	exercise	exercise	NOUN
admet-850	40	17	in	in	ADP
admet-850	40	18	collaboration	collaboration	NOUN
admet-850	40	19	with	with	ADP
admet-850	40	20	the	the	DET
admet-850	40	21	who	who	PRON
admet-850	40	22	prequalification	prequalification	NOUN
admet-850	40	23	of	of	ADP
admet-850	40	24	medicines	medicine	NOUN
admet-850	40	25	assessment	assessment	NOUN
admet-850	40	26	team	team	NOUN
admet-850	40	27	.	.	PUNCT
admet-850	41	1	final	final	ADJ
admet-850	41	2	selection	selection	NOUN
admet-850	41	3	of	of	ADP
admet-850	41	4	the	the	DET
admet-850	41	5	api	api	NOUN
admet-850	41	6	training	training	NOUN
admet-850	41	7	set	set	VERB
admet-850	41	8	for	for	ADP
admet-850	41	9	this	this	DET
admet-850	41	10	study	study	NOUN
admet-850	41	11	was	be	AUX
admet-850	41	12	performed	perform	VERB
admet-850	41	13	after	after	ADP
admet-850	41	14	public	public	ADJ
admet-850	41	15	consultation	consultation	NOUN
admet-850	41	16	according	accord	VERB
admet-850	41	17	to	to	ADP
admet-850	41	18	stakeholders	stakeholder	NOUN
admet-850	41	19	’	'	PUNCT
admet-850	41	20	needs	need	NOUN
admet-850	41	21	and	and	CCONJ
admet-850	41	22	priorities	priority	NOUN
admet-850	41	23	.	.	PUNCT
admet-850	42	1	table	table	NOUN
admet-850	42	2	1	1	NUM
admet-850	42	3	summarizes	summarize	NOUN
admet-850	42	4	the	the	DET
admet-850	42	5	main	main	ADJ
admet-850	42	6	properties	property	NOUN
admet-850	42	7	of	of	ADP
admet-850	42	8	the	the	DET
admet-850	42	9	selected	select	VERB
admet-850	42	10	apis	apis	NOUN
admet-850	42	11	that	that	PRON
admet-850	42	12	were	be	AUX
admet-850	42	13	distributed	distribute	VERB
admet-850	42	14	to	to	ADP
admet-850	42	15	10	10	NUM
admet-850	42	16	different	different	ADJ
admet-850	42	17	international	international	ADJ
admet-850	42	18	laboratories	laboratory	NOUN
admet-850	42	19	located	locate	VERB
admet-850	42	20	in	in	ADP
admet-850	42	21	who	who	PRON
admet-850	42	22	member	member	NOUN
admet-850	42	23	states	state	NOUN
admet-850	42	24	representing	represent	VERB
admet-850	42	25	the	the	DET
admet-850	42	26	african	african	ADJ
admet-850	42	27	region	region	NOUN
admet-850	42	28	,	,	PUNCT
admet-850	42	29	region	region	NOUN
admet-850	42	30	of	of	ADP
admet-850	42	31	the	the	DET
admet-850	42	32	americas	america	NOUN
admet-850	42	33	,	,	PUNCT
admet-850	42	34	south	south	ADJ
admet-850	42	35	-	-	PUNCT
admet-850	42	36	east	east	NOUN
admet-850	42	37	asian	asian	ADJ
admet-850	42	38	region	region	NOUN
admet-850	42	39	,	,	PUNCT
admet-850	42	40	european	european	ADJ
admet-850	42	41	region	region	NOUN
admet-850	42	42	,	,	PUNCT
admet-850	42	43	and	and	CCONJ
admet-850	42	44	western	western	ADJ
admet-850	42	45	pacific	pacific	PROPN
admet-850	42	46	region	region	NOUN
admet-850	42	47	,	,	PUNCT
admet-850	42	48	respectively	respectively	ADV
admet-850	42	49	.	.	PUNCT
admet-850	43	1	experimental	experimental	ADJ
admet-850	43	2	materials	material	NOUN
admet-850	43	3	all	all	DET
admet-850	43	4	drug	drug	NOUN
admet-850	43	5	substances	substance	NOUN
admet-850	43	6	used	use	VERB
admet-850	43	7	in	in	ADP
admet-850	43	8	this	this	DET
admet-850	43	9	study	study	NOUN
admet-850	43	10	were	be	AUX
admet-850	43	11	donated	donate	VERB
admet-850	43	12	by	by	ADP
admet-850	43	13	various	various	ADJ
admet-850	43	14	suppliers	supplier	NOUN
admet-850	43	15	and	and	CCONJ
admet-850	43	16	compliant	compliant	ADJ
admet-850	43	17	with	with	ADP
admet-850	43	18	compendial	compendial	ADJ
admet-850	43	19	specifications	specification	NOUN
admet-850	43	20	as	as	SCONJ
admet-850	43	21	outlined	outline	VERB
admet-850	43	22	in	in	ADP
admet-850	43	23	the	the	DET
admet-850	43	24	international	international	ADJ
admet-850	43	25	pharmacopoeia	pharmacopoeia	NOUN
admet-850	44	1	[	[	X
admet-850	44	2	8	8	NUM
admet-850	44	3	]	]	PUNCT
admet-850	44	4	and	and	CCONJ
admet-850	44	5	other	other	ADJ
admet-850	44	6	national	national	ADJ
admet-850	44	7	or	or	CCONJ
admet-850	44	8	regional	regional	ADJ
admet-850	44	9	pharmacopoeias	pharmacopoeia	NOUN
admet-850	44	10	.	.	PUNCT
admet-850	45	1	each	each	DET
admet-850	45	2	api	api	NOUN
admet-850	45	3	was	be	AUX
admet-850	45	4	provided	provide	VERB
admet-850	45	5	to	to	ADP
admet-850	45	6	multiple	multiple	ADJ
admet-850	45	7	laboratories	laboratory	NOUN
admet-850	45	8	according	accord	VERB
admet-850	45	9	to	to	ADP
admet-850	45	10	a	a	DET
admet-850	45	11	risk	risk	NOUN
admet-850	45	12	-	-	PUNCT
admet-850	45	13	based	base	VERB
admet-850	45	14	distribution	distribution	NOUN
admet-850	45	15	plan	plan	NOUN
admet-850	45	16	that	that	PRON
admet-850	45	17	assured	assure	VERB
admet-850	45	18	experimental	experimental	ADJ
admet-850	45	19	solubility	solubility	NOUN
admet-850	45	20	assessment	assessment	NOUN
admet-850	45	21	by	by	ADP
admet-850	45	22	three	three	NUM
admet-850	45	23	independent	independent	ADJ
admet-850	45	24	facilities	facility	NOUN
admet-850	45	25	.	.	PUNCT
admet-850	46	1	controlled	control	VERB
admet-850	46	2	substances	substance	NOUN
admet-850	46	3	,	,	PUNCT
admet-850	46	4	which	which	PRON
admet-850	46	5	are	be	AUX
admet-850	46	6	difficult	difficult	ADJ
admet-850	46	7	to	to	PART
admet-850	46	8	ship	ship	VERB
admet-850	46	9	across	across	ADP
admet-850	46	10	borders	border	NOUN
admet-850	46	11	,	,	PUNCT
admet-850	46	12	were	be	AUX
admet-850	46	13	measured	measure	VERB
admet-850	46	14	in	in	ADP
admet-850	46	15	two	two	NUM
admet-850	46	16	facilities	facility	NOUN
admet-850	46	17	.	.	PUNCT
admet-850	47	1	table	table	NOUN
admet-850	47	2	1	1	NUM
admet-850	47	3	summarizes	summarize	NOUN
admet-850	47	4	api	api	NOUN
admet-850	47	5	-	-	PUNCT
admet-850	47	6	specific	specific	ADJ
admet-850	47	7	information	information	NOUN
admet-850	47	8	regarding	regard	VERB
admet-850	47	9	therapeutic	therapeutic	ADJ
admet-850	47	10	indication	indication	NOUN
admet-850	47	11	,	,	PUNCT
admet-850	47	12	selected	select	VERB
admet-850	47	13	physicochemical	physicochemical	ADJ
admet-850	47	14	properties	property	NOUN
admet-850	47	15	,	,	PUNCT
admet-850	47	16	and	and	CCONJ
admet-850	47	17	the	the	DET
admet-850	47	18	provisional	provisional	ADJ
admet-850	47	19	bcs	bcs	NOUN
admet-850	47	20	classification	classification	NOUN
admet-850	47	21	assigned	assign	VERB
admet-850	47	22	by	by	ADP
admet-850	47	23	the	the	DET
admet-850	47	24	who	who	PRON
admet-850	47	25	in	in	ADP
admet-850	47	26	2006	2006	NUM
admet-850	47	27	based	base	VERB
admet-850	47	28	on	on	ADP
admet-850	47	29	solubility	solubility	NOUN
admet-850	47	30	and	and	CCONJ
admet-850	47	31	permeability	permeability	NOUN
admet-850	47	32	data	datum	NOUN
admet-850	47	33	obtained	obtain	VERB
admet-850	47	34	from	from	ADP
admet-850	47	35	the	the	DET
admet-850	47	36	primary	primary	ADJ
admet-850	47	37	literature	literature	NOUN
admet-850	47	38	.	.	PUNCT
admet-850	48	1	all	all	DET
admet-850	48	2	chemicals	chemical	NOUN
admet-850	48	3	selected	select	VERB
admet-850	48	4	for	for	ADP
admet-850	48	5	experimental	experimental	ADJ
admet-850	48	6	solubility	solubility	NOUN
admet-850	48	7	assessments	assessment	NOUN
admet-850	48	8	were	be	AUX
admet-850	48	9	of	of	ADP
admet-850	48	10	high	high	ADJ
admet-850	48	11	purity	purity	NOUN
admet-850	48	12	or	or	CCONJ
admet-850	48	13	analytical	analytical	ADJ
admet-850	48	14	grade	grade	NOUN
admet-850	48	15	and	and	CCONJ
admet-850	48	16	were	be	AUX
admet-850	48	17	used	use	VERB
admet-850	48	18	as	as	SCONJ
admet-850	48	19	received	receive	VERB
admet-850	48	20	.	.	PUNCT
admet-850	49	1	solubility	solubility	NOUN
admet-850	49	2	assessment	assessment	NOUN
admet-850	49	3	solubility	solubility	NOUN
admet-850	49	4	of	of	ADP
admet-850	49	5	the	the	DET
admet-850	49	6	highest	high	ADJ
admet-850	49	7	therapeutic	therapeutic	ADJ
admet-850	49	8	dose	dose	NOUN
admet-850	49	9	according	accord	VERB
admet-850	49	10	to	to	ADP
admet-850	49	11	the	the	DET
admet-850	49	12	approved	approve	VERB
admet-850	49	13	label	label	NOUN
admet-850	49	14	or	or	CCONJ
admet-850	49	15	summary	summary	NOUN
admet-850	49	16	of	of	ADP
admet-850	49	17	product	product	NOUN
admet-850	49	18	characteristics	characteristic	NOUN
admet-850	49	19	of	of	ADP
admet-850	49	20	the	the	DET
admet-850	49	21	originator	originator	NOUN
admet-850	49	22	was	be	AUX
admet-850	49	23	determined	determine	VERB
admet-850	49	24	for	for	ADP
admet-850	49	25	each	each	DET
admet-850	49	26	api	api	NOUN
admet-850	49	27	at	at	ADP
admet-850	49	28	37	37	NUM
admet-850	49	29	±	±	NUM
admet-850	49	30	1	1	NUM
admet-850	49	31	°	°	ADP
admet-850	49	32	c	c	NOUN
admet-850	49	33	in	in	ADP
admet-850	49	34	aqueous	aqueous	ADJ
admet-850	49	35	buffer	buffer	NOUN
admet-850	49	36	solutions	solution	NOUN
admet-850	49	37	at	at	ADP
admet-850	49	38	ph	ph	PROPN
admet-850	49	39	1.2	1.2	NUM
admet-850	49	40	,	,	PUNCT
admet-850	49	41	4.5	4.5	NUM
admet-850	49	42	,	,	PUNCT
admet-850	49	43	and	and	CCONJ
admet-850	49	44	6.8	6.8	NUM
admet-850	49	45	using	use	VERB
admet-850	49	46	a	a	DET
admet-850	49	47	globally	globally	ADV
admet-850	49	48	harmonized	harmonized	ADJ
admet-850	49	49	protocol	protocol	NOUN
admet-850	50	1	[	[	X
admet-850	50	2	9	9	NUM
admet-850	50	3	]	]	PUNCT
admet-850	50	4	.	.	PUNCT
admet-850	51	1	across	across	ADP
admet-850	51	2	the	the	DET
admet-850	51	3	various	various	ADJ
admet-850	51	4	laboratories	laboratory	NOUN
admet-850	51	5	engaged	engage	VERB
admet-850	51	6	in	in	ADP
admet-850	51	7	this	this	DET
admet-850	51	8	study	study	NOUN
admet-850	51	9	,	,	PUNCT
admet-850	51	10	equilibrium	equilibrium	NOUN
admet-850	51	11	solubility	solubility	NOUN
admet-850	51	12	was	be	AUX
admet-850	51	13	quantified	quantify	VERB
admet-850	51	14	by	by	ADP
admet-850	51	15	the	the	DET
admet-850	51	16	“	"	PUNCT
admet-850	51	17	shake	shake	NOUN
admet-850	51	18	flask	flask	NOUN
admet-850	51	19	”	"	PUNCT
admet-850	51	20	method	method	NOUN
admet-850	51	21	supported	support	VERB
admet-850	51	22	by	by	ADP
admet-850	51	23	a	a	DET
admet-850	51	24	validated	validate	VERB
admet-850	51	25	,	,	PUNCT
admet-850	51	26	stabilityindicating	stabilityindicate	VERB
admet-850	51	27	analytical	analytical	ADJ
admet-850	51	28	methodology	methodology	NOUN
admet-850	51	29	such	such	ADJ
admet-850	51	30	as	as	ADP
admet-850	51	31	high	high	ADJ
admet-850	51	32	-	-	PUNCT
admet-850	51	33	performance	performance	NOUN
admet-850	51	34	liquid	liquid	ADJ
admet-850	51	35	chromatography	chromatography	NOUN
admet-850	51	36	.	.	PUNCT
admet-850	52	1	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	PROPN
admet-850	53	1	valeria	valeria	PROPN
admet-850	53	2	gigante	gigante	PROPN
admet-850	53	3	et	et	PROPN
admet-850	53	4	al	al	PROPN
admet-850	53	5	.	.	PROPN
admet-850	53	6	admet	admet	PROPN
admet-850	53	7	&	&	CCONJ
admet-850	53	8	dmpk	dmpk	PROPN
admet-850	53	9	9(1	9(1	NUM
admet-850	53	10	)	)	PUNCT
admet-850	53	11	(	(	PUNCT
admet-850	53	12	2021	2021	NUM
admet-850	53	13	)	)	PUNCT
admet-850	53	14	23	23	NUM
admet-850	53	15	-	-	SYM
admet-850	53	16	39	39	NUM
admet-850	53	17	26	26	NUM
admet-850	53	18	table	table	NOUN
admet-850	53	19	1	1	NUM
admet-850	53	20	.	.	PUNCT
admet-850	54	1	active	active	ADJ
admet-850	54	2	pharmaceutical	pharmaceutical	ADJ
admet-850	54	3	ingredients	ingredient	NOUN
admet-850	54	4	prioritized	prioritize	VERB
admet-850	54	5	for	for	ADP
admet-850	54	6	who	who	PRON
admet-850	54	7	bcs	bcs	VERB
admet-850	54	8	classification	classification	NOUN
admet-850	54	9	in	in	ADP
admet-850	54	10	cycle	cycle	NOUN
admet-850	54	11	ii	ii	PROPN
admet-850	54	12	api	api	NOUN
admet-850	54	13	(	(	PUNCT
admet-850	54	14	solid	solid	ADJ
admet-850	54	15	form	form	NOUN
admet-850	54	16	listed	list	VERB
admet-850	54	17	in	in	ADP
admet-850	54	18	eml	eml	NOUN
admet-850	54	19	)	)	PUNCT
admet-850	54	20	therapeutic	therapeutic	ADJ
admet-850	54	21	area	area	NOUN
admet-850	54	22	indication	indication	VERB
admet-850	54	23	a	a	DET
admet-850	54	24	highest	high	ADJ
admet-850	54	25	therapeutic	therapeutic	ADJ
admet-850	54	26	dose	dose	NOUN
admet-850	54	27	[	[	X
admet-850	54	28	mg	mg	X
admet-850	54	29	]	]	X
admet-850	54	30	b	b	NOUN
admet-850	54	31	highest	high	ADJ
admet-850	54	32	strength	strength	NOUN
admet-850	55	1	[	[	X
admet-850	55	2	mg	mg	X
admet-850	55	3	]	]	PUNCT
admet-850	55	4	2006	2006	NUM
admet-850	55	5	who	who	PRON
admet-850	55	6	provisiona	provisiona	VERB
admet-850	55	7	l	l	PROPN
admet-850	55	8	bcs	bcs	PROPN
admet-850	55	9	c	c	PROPN
admet-850	55	10	logp	logp	NOUN
admet-850	55	11	d	d	X
admet-850	55	12	mw	mw	X
admet-850	55	13	e	e	X
admet-850	55	14	[	[	X
admet-850	55	15	g	g	PROPN
admet-850	55	16	/	/	SYM
admet-850	55	17	mol	mol	NOUN
admet-850	55	18	]	]	PUNCT
admet-850	55	19	number	number	NOUN
admet-850	55	20	of	of	ADP
admet-850	55	21	suppliers	supplier	NOUN
admet-850	55	22	aciclovir	aciclovir	CCONJ
admet-850	55	23	antiviral	antiviral	ADJ
admet-850	55	24	medicines	medicine	NOUN
admet-850	55	25	antiherpes	antiherpe	VERB
admet-850	55	26	medicines	medicine	VERB
admet-850	55	27	800	800	NUM
admet-850	55	28	200	200	NUM
admet-850	55	29	iii	iii	NUM
admet-850	55	30	-1.40	-1.40	NUM
admet-850	55	31	225.2	225.2	NUM
admet-850	55	32	1	1	NUM
admet-850	55	33	amoxicillin	amoxicillin	NOUN
admet-850	55	34	(	(	PUNCT
admet-850	55	35	trihydrate	trihydrate	NOUN
admet-850	55	36	)	)	PUNCT
admet-850	55	37	antibacterials	antibacterial	NOUN
admet-850	55	38	antibiotics	antibiotic	NOUN
admet-850	56	1	3000	3000	NUM
admet-850	56	2	500	500	NUM
admet-850	57	1	i	i	PRON
admet-850	57	2	-1.94	-1.94	VERB
admet-850	57	3	419.5	419.5	NUM
admet-850	57	4	2	2	NUM
admet-850	57	5	azithromycin	azithromycin	NOUN
admet-850	57	6	(	(	PUNCT
admet-850	57	7	dihydrate	dihydrate	NOUN
admet-850	57	8	)	)	PUNCT
admet-850	57	9	antibacterials	antibacterial	NOUN
admet-850	57	10	antibiotics	antibiotic	NOUN
admet-850	57	11	2000	2000	NUM
admet-850	57	12	500	500	NUM
admet-850	57	13	iv	iv	NUM
admet-850	57	14	/	/	SYM
admet-850	57	15	ii	ii	PROPN
admet-850	57	16	3.39	3.39	NUM
admet-850	57	17	785.0	785.0	NUM
admet-850	57	18	1	1	NUM
admet-850	57	19	cefixime	cefixime	NOUN
admet-850	57	20	(	(	PUNCT
admet-850	57	21	trihydrate	trihydrate	ADJ
admet-850	57	22	)	)	PUNCT
admet-850	57	23	antibacterials	antibacterial	NOUN
admet-850	57	24	antibiotics	antibiotic	NOUN
admet-850	57	25	400	400	NUM
admet-850	57	26	400	400	NUM
admet-850	57	27	iv	iv	NUM
admet-850	57	28	-1.23	-1.23	NUM
admet-850	57	29	507.5	507.5	NUM
admet-850	57	30	1	1	NUM
admet-850	57	31	codeine	codeine	NOUN
admet-850	57	32	(	(	PUNCT
admet-850	57	33	phosphate	phosphate	NOUN
admet-850	57	34	hemihydrate	hemihydrate	NOUN
admet-850	57	35	)	)	PUNCT
admet-850	57	36	(	(	PUNCT
admet-850	57	37	2:2:1	2:2:1	NUM
admet-850	57	38	)	)	PUNCT
admet-850	57	39	medicines	medicine	NOUN
admet-850	57	40	for	for	ADP
admet-850	57	41	pain	pain	NOUN
admet-850	57	42	and	and	CCONJ
admet-850	57	43	palliative	palliative	ADJ
admet-850	57	44	care	care	NOUN
admet-850	57	45	opioid	opioid	ADJ
admet-850	57	46	analgesics	analgesic	NOUN
admet-850	57	47	60	60	NUM
admet-850	57	48	30	30	NUM
admet-850	57	49	iii	iii	NUM
admet-850	57	50	1.61	1.61	NUM
admet-850	57	51	812.7	812.7	NUM
admet-850	57	52	1	1	NUM
admet-850	57	53	daclatasvir	daclatasvir	NOUN
admet-850	57	54	(	(	PUNCT
admet-850	57	55	dihydrochloride	dihydrochloride	PROPN
admet-850	57	56	)	)	PUNCT
admet-850	57	57	antiviral	antiviral	ADJ
admet-850	57	58	medicines	medicine	NOUN
admet-850	57	59	medicines	medicine	NOUN
admet-850	57	60	for	for	ADP
admet-850	57	61	hepatitis	hepatitis	NOUN
admet-850	57	62	c	c	NOUN
admet-850	57	63	60	60	NUM
admet-850	57	64	60	60	NUM
admet-850	57	65	not	not	PART
admet-850	57	66	classified	classify	VERB
admet-850	57	67	4.06	4.06	NUM
admet-850	57	68	811.8	811.8	NUM
admet-850	57	69	2	2	NUM
admet-850	57	70	darunavir	darunavir	X
admet-850	57	71	(	(	PUNCT
admet-850	57	72	ethanolate	ethanolate	ADJ
admet-850	57	73	)	)	PUNCT
admet-850	57	74	antiviral	antiviral	ADJ
admet-850	57	75	medicines	medicine	NOUN
admet-850	57	76	antiretrovirals	antiretroviral	NOUN
admet-850	57	77	(	(	PUNCT
admet-850	57	78	hiv	hiv	PROPN
admet-850	57	79	)	)	PUNCT
admet-850	57	80	800	800	NUM
admet-850	57	81	800	800	NUM
admet-850	57	82	not	not	PART
admet-850	57	83	classified	classify	VERB
admet-850	57	84	1.93	1.93	NUM
admet-850	57	85	593.7	593.7	NUM
admet-850	57	86	2	2	NUM
admet-850	57	87	dolutegravir	dolutegravir	NOUN
admet-850	57	88	antiviral	antiviral	ADJ
admet-850	57	89	medicines	medicine	NOUN
admet-850	57	90	antiretrovirals	antiretroviral	NOUN
admet-850	57	91	(	(	PUNCT
admet-850	57	92	hiv	hiv	PROPN
admet-850	57	93	)	)	PUNCT
admet-850	57	94	50	50	NUM
admet-850	57	95	50	50	NUM
admet-850	57	96	not	not	PART
admet-850	57	97	classified	classify	VERB
admet-850	57	98	1.20	1.20	NUM
admet-850	57	99	419.4	419.4	NUM
admet-850	57	100	1	1	NUM
admet-850	57	101	efavirenz	efavirenz	NOUN
admet-850	57	102	antiviral	antiviral	ADJ
admet-850	57	103	medicines	medicine	NOUN
admet-850	57	104	antiretrovirals	antiretroviral	NOUN
admet-850	57	105	(	(	PUNCT
admet-850	57	106	hiv	hiv	PROPN
admet-850	57	107	)	)	PUNCT
admet-850	57	108	600	600	NUM
admet-850	57	109	600	600	NUM
admet-850	57	110	iv	iv	NUM
admet-850	57	111	/	/	SYM
admet-850	57	112	ii	ii	PROPN
admet-850	57	113	4.19	4.19	NUM
admet-850	57	114	315.7	315.7	NUM
admet-850	57	115	3	3	NUM
admet-850	57	116	ethionamide	ethionamide	NOUN
admet-850	57	117	antibacterials	antibacterial	NOUN
admet-850	57	118	antituberculosi	antituberculosi	NOUN
admet-850	57	119	s	s	PART
admet-850	57	120	medicines	medicine	NOUN
admet-850	57	121	500–1000	500–1000	NUM
admet-850	57	122	250	250	NUM
admet-850	57	123	iii	iii	NOUN
admet-850	57	124	/	/	SYM
admet-850	57	125	i	i	PROPN
admet-850	57	126	1.26	1.26	NUM
admet-850	57	127	166.3	166.3	NUM
admet-850	57	128	1	1	NUM
admet-850	57	129	furosemide	furosemide	ADJ
admet-850	57	130	cardiovascular	cardiovascular	ADJ
admet-850	57	131	medicines	medicine	NOUN
admet-850	57	132	medicines	medicine	NOUN
admet-850	57	133	used	use	VERB
admet-850	57	134	in	in	ADP
admet-850	57	135	heart	heart	NOUN
admet-850	57	136	failure	failure	NOUN
admet-850	58	1	80	80	NUM
admet-850	58	2	40	40	NUM
admet-850	58	3	iv	iv	NUM
admet-850	58	4	/	/	SYM
admet-850	58	5	ii	ii	PROPN
admet-850	58	6	2.07	2.07	NUM
admet-850	58	7	330.7	330.7	NUM
admet-850	58	8	2	2	NUM
admet-850	58	9	primaquine	primaquine	NOUN
admet-850	58	10	(	(	PUNCT
admet-850	58	11	phosphate	phosphate	NOUN
admet-850	58	12	)	)	PUNCT
admet-850	58	13	(	(	PUNCT
admet-850	58	14	1:2	1:2	NUM
admet-850	58	15	)	)	PUNCT
admet-850	58	16	antiprotozoal	antiprotozoal	ADJ
admet-850	58	17	medicines	medicine	NOUN
admet-850	58	18	antimalarial	antimalarial	ADJ
admet-850	58	19	medicines	medicine	NOUN
admet-850	58	20	(	(	PUNCT
admet-850	58	21	curative	curative	ADJ
admet-850	58	22	treatment	treatment	NOUN
admet-850	58	23	of	of	ADP
admet-850	58	24	p.vivax	p.vivax	NOUN
admet-850	58	25	and	and	CCONJ
admet-850	58	26	p.ovale	p.ovale	NOUN
admet-850	58	27	infections	infection	NOUN
admet-850	58	28	)	)	PUNCT
admet-850	58	29	15	15	NUM
admet-850	58	30	15	15	NUM
admet-850	58	31	i	i	NOUN
admet-850	58	32	2.86	2.86	NUM
admet-850	58	33	455.3	455.3	NUM
admet-850	58	34	2	2	NUM
admet-850	58	35	pyrimethamine	pyrimethamine	NOUN
admet-850	58	36	antiprotozoal	antiprotozoal	NOUN
admet-850	58	37	medicines	medicine	NOUN
admet-850	58	38	antimalarial	antimalarial	ADJ
admet-850	58	39	medicines	medicine	NOUN
admet-850	58	40	75	75	NUM
admet-850	58	41	25	25	NUM
admet-850	58	42	iv	iv	NUM
admet-850	58	43	/	/	SYM
admet-850	58	44	iii	iii	NUM
admet-850	58	45	2.53	2.53	NUM
admet-850	58	46	248.7	248.7	NUM
admet-850	58	47	3	3	NUM
admet-850	58	48	raltegravir	raltegravir	NOUN
admet-850	58	49	(	(	PUNCT
admet-850	58	50	potassium	potassium	NOUN
admet-850	58	51	)	)	PUNCT
admet-850	58	52	antiviral	antiviral	ADJ
admet-850	58	53	medicines	medicine	NOUN
admet-850	58	54	antiretrovirals	antiretroviral	NOUN
admet-850	58	55	(	(	PUNCT
admet-850	58	56	hiv	hiv	PROPN
admet-850	58	57	in	in	ADP
admet-850	58	58	pregnant	pregnant	ADJ
admet-850	58	59	women	woman	NOUN
admet-850	58	60	and	and	CCONJ
admet-850	58	61	in	in	ADP
admet-850	58	62	second	second	ADJ
admet-850	58	63	-	-	PUNCT
admet-850	58	64	line	line	NOUN
admet-850	58	65	)	)	PUNCT
admet-850	58	66	400	400	NUM
admet-850	58	67	400	400	NUM
admet-850	58	68	not	not	PART
admet-850	58	69	classified	classify	VERB
admet-850	58	70	1.97	1.97	NUM
admet-850	58	71	482.5	482.5	NUM
admet-850	58	72	2	2	NUM
admet-850	58	73	rifampicin	rifampicin	VERB
admet-850	58	74	antibacterials	antibacterial	NOUN
admet-850	58	75	antituberculosi	antituberculosi	NOUN
admet-850	58	76	s	s	PART
admet-850	58	77	/	/	SYM
admet-850	58	78	antileprosy	antileprosy	NOUN
admet-850	58	79	medicines	medicine	NOUN
admet-850	58	80	750	750	NUM
admet-850	58	81	300	300	NUM
admet-850	58	82	ii	ii	NUM
admet-850	58	83	2.53	2.53	NUM
admet-850	58	84	822.9	822.9	NUM
admet-850	58	85	3	3	NUM
admet-850	58	86	tenofovir	tenofovir	NOUN
admet-850	58	87	disoproxil	disoproxil	VERB
admet-850	58	88	fumarate	fumarate	NOUN
admet-850	58	89	(	(	PUNCT
admet-850	58	90	1:1	1:1	NUM
admet-850	58	91	)	)	PUNCT
admet-850	58	92	antiviral	antiviral	ADJ
admet-850	58	93	medicines	medicine	NOUN
admet-850	58	94	antiretrovirals	antiretroviral	NOUN
admet-850	58	95	(	(	PUNCT
admet-850	58	96	hiv	hiv	NOUN
admet-850	58	97	)	)	PUNCT
admet-850	58	98	300	300	NUM
admet-850	58	99	300	300	NUM
admet-850	58	100	not	not	PART
admet-850	58	101	classified	classify	VERB
admet-850	58	102	-1.34	-1.34	NOUN
admet-850	58	103	635.5	635.5	NUM
admet-850	58	104	1	1	NUM
admet-850	58	105	a	a	PRON
admet-850	58	106	according	accord	VERB
admet-850	58	107	to	to	ADP
admet-850	58	108	the	the	DET
admet-850	58	109	21stwho	21stwho	NUM
admet-850	58	110	model	model	NOUN
admet-850	58	111	list	list	NOUN
admet-850	58	112	of	of	ADP
admet-850	58	113	essential	essential	ADJ
admet-850	58	114	medicines	medicine	NOUN
admet-850	58	115	(	(	PUNCT
admet-850	58	116	2019	2019	NUM
admet-850	58	117	)	)	PUNCT
admet-850	58	118	b	b	NOUN
admet-850	58	119	according	accord	VERB
admet-850	58	120	to	to	ADP
admet-850	58	121	summary	summary	NOUN
admet-850	58	122	of	of	ADP
admet-850	58	123	product	product	NOUN
admet-850	58	124	characteristics	characteristic	NOUN
admet-850	58	125	from	from	ADP
admet-850	58	126	who	who	PRON
admet-850	58	127	-	-	PUNCT
admet-850	58	128	pq	pq	NOUN
admet-850	58	129	or	or	CCONJ
admet-850	58	130	national	national	ADJ
admet-850	58	131	/	/	SYM
admet-850	58	132	regional	regional	ADJ
admet-850	58	133	regulatory	regulatory	ADJ
admet-850	58	134	authority	authority	NOUN
admet-850	58	135	c	c	NOUN
admet-850	58	136	proposal	proposal	NOUN
admet-850	58	137	to	to	PART
admet-850	58	138	waive	waive	VERB
admet-850	58	139	in	in	ADP
admet-850	58	140	vivo	vivo	ADJ
admet-850	58	141	bioequivalence	bioequivalence	NOUN
admet-850	58	142	requirements	requirement	NOUN
admet-850	58	143	for	for	ADP
admet-850	58	144	who	who	PRON
admet-850	58	145	model	model	NOUN
admet-850	58	146	list	list	NOUN
admet-850	58	147	of	of	ADP
admet-850	58	148	essential	essential	ADJ
admet-850	58	149	medicines	medicine	NOUN
admet-850	58	150	immediate	immediate	ADJ
admet-850	58	151	-	-	PUNCT
admet-850	58	152	release	release	NOUN
admet-850	58	153	,	,	PUNCT
admet-850	58	154	solid	solid	ADJ
admet-850	58	155	oral	oral	ADJ
admet-850	58	156	dosage	dosage	NOUN
admet-850	58	157	forms	form	NOUN
admet-850	58	158	.	.	PUNCT
admet-850	59	1	in	in	ADP
admet-850	59	2	:	:	PUNCT
admet-850	59	3	who	who	PRON
admet-850	59	4	expert	expert	ADJ
admet-850	59	5	committee	committee	NOUN
admet-850	59	6	on	on	ADP
admet-850	59	7	specifications	specification	NOUN
admet-850	59	8	for	for	ADP
admet-850	59	9	pharmaceutical	pharmaceutical	ADJ
admet-850	59	10	preparations	preparation	NOUN
admet-850	59	11	:	:	PUNCT
admet-850	59	12	fortieth	fortieth	ADJ
admet-850	59	13	report	report	NOUN
admet-850	59	14	.	.	PUNCT
admet-850	60	1	geneva	geneva	PROPN
admet-850	60	2	:	:	PUNCT
admet-850	60	3	world	world	PROPN
admet-850	60	4	health	health	NOUN
admet-850	60	5	organization	organization	NOUN
admet-850	60	6	;	;	PUNCT
admet-850	60	7	2006	2006	NUM
admet-850	60	8	:	:	PUNCT
admet-850	60	9	annex	annex	VERB
admet-850	60	10	8	8	NUM
admet-850	60	11	(	(	PUNCT
admet-850	60	12	who	who	PRON
admet-850	60	13	technical	technical	ADJ
admet-850	60	14	report	report	NOUN
admet-850	60	15	series	series	NOUN
admet-850	60	16	,	,	PUNCT
admet-850	60	17	no	no	INTJ
admet-850	60	18	.	.	PROPN
admet-850	60	19	937	937	NUM
admet-850	60	20	;	;	PUNCT
admet-850	61	1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	61	2	,	,	PUNCT
admet-850	61	3	accessed	access	VERB
admet-850	61	4	4	4	NUM
admet-850	61	5	may	may	NOUN
admet-850	61	6	2020	2020	NUM
admet-850	61	7	)	)	PUNCT
admet-850	61	8	.	.	PUNCT
admet-850	62	1	updated	update	VERB
admet-850	62	2	requirement	requirement	NOUN
admet-850	62	3	in	in	ADP
admet-850	62	4	:	:	PUNCT
admet-850	62	5	multisource	multisource	ADJ
admet-850	62	6	(	(	PUNCT
admet-850	62	7	generic	generic	ADJ
admet-850	62	8	)	)	PUNCT
admet-850	62	9	pharmaceutical	pharmaceutical	NOUN
admet-850	62	10	products	product	NOUN
admet-850	62	11	:	:	PUNCT
admet-850	62	12	guidelines	guideline	NOUN
admet-850	62	13	on	on	ADP
admet-850	62	14	registration	registration	NOUN
admet-850	62	15	requirements	requirement	NOUN
admet-850	62	16	to	to	PART
admet-850	62	17	establish	establish	VERB
admet-850	62	18	interchangeability	interchangeability	NOUN
admet-850	62	19	.	.	PUNCT
admet-850	63	1	in	in	ADP
admet-850	63	2	:	:	PUNCT
admet-850	63	3	who	who	PRON
admet-850	63	4	expert	expert	ADJ
admet-850	63	5	committee	committee	NOUN
admet-850	63	6	on	on	ADP
admet-850	63	7	specifications	specification	NOUN
admet-850	63	8	for	for	ADP
admet-850	63	9	pharmaceutical	pharmaceutical	ADJ
admet-850	63	10	preparations	preparation	NOUN
admet-850	63	11	:	:	PUNCT
admet-850	63	12	fifty	fifty	NUM
admet-850	63	13	-	-	PUNCT
admet-850	63	14	first	first	ADJ
admet-850	63	15	report	report	NOUN
admet-850	63	16	.	.	PUNCT
admet-850	64	1	geneva	geneva	NOUN
admet-850	64	2	:	:	PUNCT
admet-850	64	3	world	world	PROPN
admet-850	64	4	health	health	NOUN
admet-850	64	5	organization	organization	NOUN
admet-850	64	6	;	;	PUNCT
admet-850	64	7	2017	2017	NUM
admet-850	64	8	:	:	PUNCT
admet-850	64	9	annex	annex	VERB
admet-850	64	10	6	6	NUM
admet-850	64	11	(	(	PUNCT
admet-850	64	12	who	who	PRON
admet-850	64	13	technical	technical	ADJ
admet-850	64	14	report	report	NOUN
admet-850	64	15	series	series	NOUN
admet-850	64	16	,	,	PUNCT
admet-850	64	17	no	no	INTJ
admet-850	64	18	.	.	NOUN
admet-850	64	19	1003	1003	NUM
admet-850	64	20	;	;	PUNCT
admet-850	64	21	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	NOUN
admet-850	64	22	,	,	PUNCT
admet-850	64	23	accessed	access	VERB
admet-850	64	24	2	2	NUM
admet-850	64	25	october	october	NOUN
admet-850	64	26	2020	2020	NUM
admet-850	64	27	)	)	PUNCT
admet-850	64	28	.	.	PUNCT
admet-850	65	1	d	d	NOUN
admet-850	65	2	in	in	ADP
admet-850	65	3	silico	silico	NOUN
admet-850	65	4	log	log	VERB
admet-850	65	5	p	p	NOUN
admet-850	65	6	values	value	NOUN
admet-850	65	7	predicted	predict	VERB
admet-850	65	8	using	use	VERB
admet-850	65	9	admet	admet	PROPN
admet-850	65	10	predictor	predictor	NOUN
admet-850	65	11	®	®	NOUN
admet-850	65	12	9.5	9.5	NUM
admet-850	65	13	(	(	PUNCT
admet-850	65	14	simulations	simulation	NOUN
admet-850	65	15	plus	plus	NOUN
admet-850	65	16	,	,	PUNCT
admet-850	65	17	inc	inc	PROPN
admet-850	65	18	.	.	PROPN
admet-850	65	19	,	,	PUNCT
admet-850	65	20	lancaster	lancaster	PROPN
admet-850	65	21	,	,	PUNCT
admet-850	65	22	ca	ca	NOUN
admet-850	65	23	)	)	PUNCT
admet-850	65	24	e	e	NOUN
admet-850	65	25	the	the	DET
admet-850	65	26	molecular	molecular	ADJ
admet-850	65	27	weight	weight	NOUN
admet-850	65	28	corresponds	correspond	VERB
admet-850	65	29	to	to	ADP
admet-850	65	30	the	the	DET
admet-850	65	31	solid	solid	ADJ
admet-850	65	32	form	form	NOUN
admet-850	65	33	of	of	ADP
admet-850	65	34	the	the	DET
admet-850	65	35	api	api	NOUN
admet-850	65	36	used	use	VERB
admet-850	65	37	for	for	ADP
admet-850	65	38	the	the	DET
admet-850	65	39	solubility	solubility	NOUN
admet-850	65	40	experiments	experiment	NOUN
admet-850	65	41	as	as	SCONJ
admet-850	65	42	indicated	indicate	VERB
admet-850	65	43	in	in	ADP
admet-850	65	44	column	column	NOUN
admet-850	65	45	1	1	NUM
admet-850	65	46	of	of	ADP
admet-850	65	47	this	this	DET
admet-850	65	48	table	table	NOUN
admet-850	65	49	.	.	PUNCT
admet-850	66	1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	66	2	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	66	3	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	NOUN
admet-850	66	4	admet	admet	NOUN
admet-850	66	5	&	&	CCONJ
admet-850	66	6	dmpk	dmpk	PROPN
admet-850	66	7	9(1	9(1	NUM
admet-850	66	8	)	)	PUNCT
admet-850	66	9	(	(	PUNCT
admet-850	66	10	2021	2021	NUM
admet-850	66	11	)	)	PUNCT
admet-850	66	12	23	23	NUM
admet-850	66	13	-	-	SYM
admet-850	66	14	39	39	NUM
admet-850	66	15	enhancing	enhance	VERB
admet-850	66	16	robustness	robustness	NOUN
admet-850	66	17	of	of	ADP
admet-850	66	18	the	the	PRON
admet-850	66	19	who	who	PRON
admet-850	66	20	biopharmaceutical	biopharmaceutical	ADJ
admet-850	66	21	classification	classification	NOUN
admet-850	66	22	system	system	NOUN
admet-850	66	23	doi	doi	NOUN
admet-850	66	24	:	:	PUNCT
admet-850	66	25	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	66	26	27	27	NUM
admet-850	66	27	the	the	DET
admet-850	66	28	time	time	NOUN
admet-850	66	29	required	require	VERB
admet-850	66	30	to	to	PART
admet-850	66	31	reach	reach	VERB
admet-850	66	32	equilibrium	equilibrium	NOUN
admet-850	66	33	was	be	AUX
admet-850	66	34	experimentally	experimentally	ADV
admet-850	66	35	defined	define	VERB
admet-850	66	36	during	during	ADP
admet-850	66	37	a	a	DET
admet-850	66	38	preliminary	preliminary	ADJ
admet-850	66	39	experiment	experiment	NOUN
admet-850	66	40	performed	perform	VERB
admet-850	66	41	at	at	ADP
admet-850	66	42	the	the	DET
admet-850	66	43	ph	ph	ADJ
admet-850	66	44	value	value	NOUN
admet-850	66	45	where	where	SCONJ
admet-850	66	46	lowest	low	ADJ
admet-850	66	47	api	api	NOUN
admet-850	66	48	solubility	solubility	NOUN
admet-850	66	49	was	be	AUX
admet-850	66	50	predicted	predict	VERB
admet-850	66	51	.	.	PUNCT
admet-850	67	1	subsequently	subsequently	ADV
admet-850	67	2	,	,	PUNCT
admet-850	67	3	pivotal	pivotal	ADJ
admet-850	67	4	experiments	experiment	NOUN
admet-850	67	5	were	be	AUX
admet-850	67	6	initiated	initiate	VERB
admet-850	67	7	in	in	ADP
admet-850	67	8	triplicate	triplicate	NOUN
admet-850	67	9	at	at	ADP
admet-850	67	10	ph	ph	PROPN
admet-850	67	11	1.2	1.2	NUM
admet-850	67	12	,	,	PUNCT
admet-850	67	13	4.5	4.5	NUM
admet-850	67	14	,	,	PUNCT
admet-850	67	15	and	and	CCONJ
admet-850	67	16	6.8	6.8	NUM
admet-850	67	17	,	,	PUNCT
admet-850	67	18	respectively	respectively	ADV
admet-850	67	19	,	,	PUNCT
admet-850	67	20	using	use	VERB
admet-850	67	21	approximately	approximately	ADV
admet-850	67	22	a	a	DET
admet-850	67	23	10	10	NUM
admet-850	67	24	-	-	SYM
admet-850	67	25	50	50	NUM
admet-850	67	26	%	%	NOUN
admet-850	67	27	excess	excess	ADJ
admet-850	67	28	amount	amount	NOUN
admet-850	67	29	of	of	ADP
admet-850	67	30	the	the	DET
admet-850	67	31	api	api	NOUN
admet-850	67	32	estimated	estimate	VERB
admet-850	67	33	to	to	PART
admet-850	67	34	meet	meet	VERB
admet-850	67	35	the	the	DET
admet-850	67	36	who	who	PRON
admet-850	67	37	“	"	PUNCT
admet-850	67	38	high	high	ADJ
admet-850	67	39	solubility	solubility	NOUN
admet-850	67	40	”	"	PUNCT
admet-850	67	41	class	class	NOUN
admet-850	67	42	boundary	boundary	NOUN
admet-850	67	43	(	(	PUNCT
admet-850	67	44	see	see	VERB
admet-850	67	45	below	below	ADV
admet-850	67	46	)	)	PUNCT
admet-850	67	47	.	.	PUNCT
admet-850	68	1	undissolved	undissolve	VERB
admet-850	68	2	solid	solid	ADJ
admet-850	68	3	was	be	AUX
admet-850	68	4	separated	separate	VERB
admet-850	68	5	by	by	ADP
admet-850	68	6	either	either	PRON
admet-850	68	7	filtration	filtration	NOUN
admet-850	68	8	or	or	CCONJ
admet-850	68	9	centrifugation	centrifugation	NOUN
admet-850	68	10	prior	prior	ADV
admet-850	68	11	to	to	ADP
admet-850	68	12	api	api	NOUN
admet-850	68	13	quantitation	quantitation	NOUN
admet-850	68	14	employing	employ	VERB
admet-850	68	15	a	a	DET
admet-850	68	16	validated	validate	VERB
admet-850	68	17	,	,	PUNCT
admet-850	68	18	stability	stability	NOUN
admet-850	68	19	-	-	PUNCT
admet-850	68	20	indicating	indicate	VERB
admet-850	68	21	analytical	analytical	ADJ
admet-850	68	22	methodology	methodology	NOUN
admet-850	68	23	.	.	PUNCT
admet-850	69	1	individual	individual	ADJ
admet-850	69	2	solubility	solubility	NOUN
admet-850	69	3	was	be	AUX
admet-850	69	4	reported	report	VERB
admet-850	69	5	in	in	ADP
admet-850	69	6	mg	mg	PROPN
admet-850	69	7	/	/	SYM
admet-850	69	8	ml	ml	NOUN
admet-850	69	9	.	.	PUNCT
admet-850	70	1	as	as	SCONJ
admet-850	70	2	specified	specify	VERB
admet-850	70	3	in	in	ADP
admet-850	70	4	the	the	DET
admet-850	70	5	who	who	PRON
admet-850	70	6	technical	technical	ADJ
admet-850	70	7	report	report	PROPN
admet-850	70	8	series	series	PROPN
admet-850	70	9	no	no	NOUN
admet-850	70	10	.	.	PUNCT
admet-850	70	11	1003	1003	NUM
admet-850	70	12	annex	annex	VERB
admet-850	70	13	7	7	NUM
admet-850	70	14	entitled	entitled	ADJ
admet-850	70	15	“	"	PUNCT
admet-850	70	16	multisource	multisource	ADJ
admet-850	70	17	(	(	PUNCT
admet-850	70	18	generic	generic	ADJ
admet-850	70	19	)	)	PUNCT
admet-850	70	20	pharmaceutical	pharmaceutical	NOUN
admet-850	70	21	products	product	NOUN
admet-850	70	22	:	:	PUNCT
admet-850	70	23	guidelines	guideline	NOUN
admet-850	70	24	on	on	ADP
admet-850	70	25	registration	registration	NOUN
admet-850	70	26	requirements	requirement	NOUN
admet-850	70	27	to	to	PART
admet-850	70	28	establish	establish	VERB
admet-850	70	29	interchangeability	interchangeability	NOUN
admet-850	70	30	”	"	PUNCT
admet-850	71	1	[	[	X
admet-850	71	2	5	5	NUM
admet-850	71	3	]	]	PUNCT
admet-850	71	4	,	,	PUNCT
admet-850	71	5	an	an	DET
admet-850	71	6	api	api	NOUN
admet-850	71	7	is	be	AUX
admet-850	71	8	considered	consider	VERB
admet-850	71	9	“	"	PUNCT
admet-850	71	10	highly	highly	ADV
admet-850	71	11	soluble	soluble	ADJ
admet-850	71	12	”	"	PUNCT
admet-850	71	13	when	when	SCONJ
admet-850	71	14	the	the	DET
admet-850	71	15	dose	dose	PROPN
admet-850	71	16	/	/	SYM
admet-850	71	17	solubility	solubility	NOUN
admet-850	71	18	volume	volume	NOUN
admet-850	71	19	(	(	PUNCT
admet-850	71	20	dsv	dsv	PROPN
admet-850	71	21	)	)	PUNCT
admet-850	71	22	representing	represent	VERB
admet-850	71	23	the	the	DET
admet-850	71	24	volume	volume	NOUN
admet-850	71	25	of	of	ADP
admet-850	71	26	liquid	liquid	NOUN
admet-850	71	27	necessary	necessary	ADJ
admet-850	71	28	to	to	PART
admet-850	71	29	completely	completely	ADV
admet-850	71	30	dissolve	dissolve	VERB
admet-850	71	31	the	the	DET
admet-850	71	32	highest	high	ADJ
admet-850	71	33	single	single	ADJ
admet-850	71	34	therapeutic	therapeutic	ADJ
admet-850	71	35	dose	dose	NOUN
admet-850	71	36	of	of	ADP
admet-850	71	37	the	the	DET
admet-850	71	38	api	api	NOUN
admet-850	71	39	as	as	SCONJ
admet-850	71	40	recommended	recommend	VERB
admet-850	71	41	by	by	ADP
admet-850	71	42	the	the	DET
admet-850	71	43	approved	approve	VERB
admet-850	71	44	label	label	NOUN
admet-850	71	45	or	or	CCONJ
admet-850	71	46	summary	summary	NOUN
admet-850	71	47	of	of	ADP
admet-850	71	48	product	product	NOUN
admet-850	71	49	characteristics	characteristic	NOUN
admet-850	71	50	of	of	ADP
admet-850	71	51	the	the	DET
admet-850	71	52	originator	originator	NOUN
admet-850	71	53	product	product	NOUN
admet-850	71	54	is	be	AUX
admet-850	71	55	consistently	consistently	ADV
admet-850	71	56	smaller	small	ADJ
admet-850	71	57	than	than	ADP
admet-850	71	58	250	250	NUM
admet-850	71	59	ml	ml	NOUN
admet-850	71	60	over	over	ADP
admet-850	71	61	the	the	DET
admet-850	71	62	entire	entire	ADJ
admet-850	71	63	phrange	phrange	NOUN
admet-850	71	64	of	of	ADP
admet-850	71	65	1.2	1.2	NUM
admet-850	71	66	–	–	PUNCT
admet-850	71	67	6.8	6.8	NUM
admet-850	71	68	.	.	PUNCT
admet-850	72	1	permeability	permeability	NOUN
admet-850	72	2	data	datum	NOUN
admet-850	72	3	to	to	PART
admet-850	72	4	estimate	estimate	VERB
admet-850	72	5	the	the	DET
admet-850	72	6	consequences	consequence	NOUN
admet-850	72	7	of	of	ADP
admet-850	72	8	the	the	DET
admet-850	72	9	experimental	experimental	ADJ
admet-850	72	10	solubility	solubility	NOUN
admet-850	72	11	results	result	NOUN
admet-850	72	12	generated	generate	VERB
admet-850	72	13	by	by	ADP
admet-850	72	14	this	this	DET
admet-850	72	15	global	global	PROPN
admet-850	72	16	laboratory	laboratory	NOUN
admet-850	72	17	consortium	consortium	NOUN
admet-850	72	18	using	use	VERB
admet-850	72	19	the	the	DET
admet-850	72	20	harmonized	harmonize	VERB
admet-850	72	21	who	who	PRON
admet-850	72	22	protocol	protocol	VERB
admet-850	72	23	on	on	ADP
admet-850	72	24	bcs	bcs	NOUN
admet-850	72	25	classification	classification	NOUN
admet-850	72	26	of	of	ADP
admet-850	72	27	each	each	DET
admet-850	72	28	api	api	NOUN
admet-850	72	29	,	,	PUNCT
admet-850	72	30	it	it	PRON
admet-850	72	31	was	be	AUX
admet-850	72	32	necessary	necessary	ADJ
admet-850	72	33	to	to	PART
admet-850	72	34	obtain	obtain	VERB
admet-850	72	35	api	api	NOUN
admet-850	72	36	-	-	PUNCT
admet-850	72	37	specific	specific	ADJ
admet-850	72	38	permeability	permeability	NOUN
admet-850	72	39	data	datum	NOUN
admet-850	72	40	indicative	indicative	ADJ
admet-850	72	41	of	of	ADP
admet-850	72	42	the	the	DET
admet-850	72	43	fraction	fraction	NOUN
admet-850	72	44	absorbed	absorb	VERB
admet-850	72	45	in	in	ADP
admet-850	72	46	humans	human	NOUN
admet-850	72	47	(	(	PUNCT
admet-850	72	48	fa	fa	NOUN
admet-850	72	49	)	)	PUNCT
admet-850	72	50	.	.	PUNCT
admet-850	73	1	to	to	PART
admet-850	73	2	limit	limit	VERB
admet-850	73	3	variability	variability	NOUN
admet-850	73	4	and	and	CCONJ
admet-850	73	5	selection	selection	NOUN
admet-850	73	6	bias	bias	NOUN
admet-850	73	7	associated	associate	VERB
admet-850	73	8	with	with	ADP
admet-850	73	9	different	different	ADJ
admet-850	73	10	experimental	experimental	ADJ
admet-850	73	11	conditions	condition	NOUN
admet-850	73	12	used	use	VERB
admet-850	73	13	to	to	PART
admet-850	73	14	define	define	VERB
admet-850	73	15	api	api	NOUN
admet-850	73	16	permeability	permeability	NOUN
admet-850	73	17	as	as	SCONJ
admet-850	73	18	shown	show	VERB
admet-850	73	19	by	by	ADP
admet-850	73	20	larregieu	larregieu	NOUN
admet-850	73	21	and	and	CCONJ
admet-850	73	22	benet	benet	PROPN
admet-850	73	23	for	for	ADP
admet-850	73	24	caco-2	caco-2	NUM
admet-850	73	25	cell	cell	NOUN
admet-850	73	26	permeability	permeability	NOUN
admet-850	73	27	assessment	assessment	NOUN
admet-850	73	28	[	[	X
admet-850	73	29	10	10	NUM
admet-850	73	30	]	]	X
admet-850	73	31	,	,	PUNCT
admet-850	73	32	a	a	DET
admet-850	73	33	consistent	consistent	ADJ
admet-850	73	34	computational	computational	ADJ
admet-850	73	35	simulation	simulation	NOUN
admet-850	73	36	approach	approach	NOUN
admet-850	73	37	was	be	AUX
admet-850	73	38	implemented	implement	VERB
admet-850	73	39	using	use	VERB
admet-850	73	40	gastroplus	gastroplus	ADJ
admet-850	73	41	®	®	NOUN
admet-850	73	42	9.7	9.7	NUM
admet-850	73	43	(	(	PUNCT
admet-850	73	44	simulations	simulation	NOUN
admet-850	73	45	plus	plus	CCONJ
admet-850	73	46	,	,	PUNCT
admet-850	73	47	inc	inc	PROPN
admet-850	73	48	.	.	PROPN
admet-850	73	49	,	,	PUNCT
admet-850	73	50	lancaster	lancaster	PROPN
admet-850	73	51	,	,	PUNCT
admet-850	73	52	ca	ca	NOUN
admet-850	73	53	)	)	PUNCT
admet-850	73	54	under	under	ADP
admet-850	73	55	a	a	DET
admet-850	73	56	free	free	ADJ
admet-850	73	57	academic	academic	ADJ
admet-850	73	58	license	license	NOUN
admet-850	73	59	.	.	PUNCT
admet-850	74	1	gastroplus	gastroplus	ADJ
admet-850	74	2	®	®	PROPN
admet-850	74	3	9.7	9.7	NUM
admet-850	74	4	is	be	AUX
admet-850	74	5	a	a	DET
admet-850	74	6	bottom	bottom	ADJ
admet-850	74	7	-	-	PUNCT
admet-850	74	8	up	up	NOUN
admet-850	74	9	,	,	PUNCT
admet-850	74	10	whole	whole	ADJ
admet-850	74	11	-	-	PUNCT
admet-850	74	12	body	body	NOUN
admet-850	74	13	physiologically	physiologically	ADV
admet-850	74	14	-	-	PUNCT
admet-850	74	15	based	base	VERB
admet-850	74	16	pharmacokinetic	pharmacokinetic	ADJ
admet-850	74	17	(	(	PUNCT
admet-850	74	18	pbpk	pbpk	ADJ
admet-850	74	19	)	)	PUNCT
admet-850	74	20	model	model	NOUN
admet-850	74	21	that	that	PRON
admet-850	74	22	uses	use	VERB
admet-850	74	23	the	the	DET
admet-850	74	24	advanced	advanced	ADJ
admet-850	74	25	compartmental	compartmental	ADJ
admet-850	74	26	absorption	absorption	NOUN
admet-850	74	27	transit	transit	NOUN
admet-850	74	28	(	(	PUNCT
admet-850	74	29	acat	acat	ADJ
admet-850	74	30	)	)	PUNCT
admet-850	74	31	mechanistic	mechanistic	ADJ
admet-850	74	32	absorption	absorption	NOUN
admet-850	74	33	model	model	NOUN
admet-850	74	34	to	to	PART
admet-850	74	35	mimic	mimic	VERB
admet-850	74	36	the	the	DET
admet-850	74	37	human	human	ADJ
admet-850	74	38	intestinal	intestinal	ADJ
admet-850	74	39	absorption	absorption	NOUN
admet-850	74	40	of	of	ADP
admet-850	74	41	oral	oral	ADJ
admet-850	74	42	formulations	formulation	NOUN
admet-850	74	43	from	from	ADP
admet-850	74	44	the	the	DET
admet-850	74	45	gi	gi	NOUN
admet-850	74	46	tract	tract	NOUN
admet-850	74	47	[	[	X
admet-850	74	48	11	11	NUM
admet-850	74	49	]	]	PUNCT
admet-850	74	50	.	.	PUNCT
admet-850	75	1	simulations	simulation	NOUN
admet-850	75	2	were	be	AUX
admet-850	75	3	conducted	conduct	VERB
admet-850	75	4	for	for	ADP
admet-850	75	5	the	the	DET
admet-850	75	6	highest	high	ADJ
admet-850	75	7	therapeutic	therapeutic	ADJ
admet-850	75	8	dose	dose	NOUN
admet-850	75	9	as	as	ADV
admet-850	75	10	well	well	ADV
admet-850	75	11	as	as	ADP
admet-850	75	12	the	the	DET
admet-850	75	13	highest	high	ADJ
admet-850	75	14	strength	strength	NOUN
admet-850	75	15	of	of	ADP
admet-850	75	16	each	each	DET
admet-850	75	17	api	api	NOUN
admet-850	75	18	reported	report	VERB
admet-850	75	19	in	in	ADP
admet-850	75	20	table	table	NOUN
admet-850	75	21	1	1	NUM
admet-850	75	22	using	use	VERB
admet-850	75	23	the	the	DET
admet-850	75	24	human	human	ADJ
admet-850	75	25	fasted	fast	VERB
admet-850	75	26	physiological	physiological	ADJ
admet-850	75	27	model	model	NOUN
admet-850	75	28	for	for	ADP
admet-850	75	29	an	an	DET
admet-850	75	30	individual	individual	NOUN
admet-850	75	31	with	with	ADP
admet-850	75	32	an	an	DET
admet-850	75	33	average	average	ADJ
admet-850	75	34	bodyweight	bodyweight	NOUN
admet-850	75	35	of	of	ADP
admet-850	75	36	70	70	NUM
admet-850	75	37	kg	kg	NOUN
admet-850	75	38	without	without	ADP
admet-850	75	39	enterohepatic	enterohepatic	ADJ
admet-850	75	40	recirculation	recirculation	NOUN
admet-850	75	41	following	follow	VERB
admet-850	75	42	administration	administration	NOUN
admet-850	75	43	of	of	ADP
admet-850	75	44	an	an	DET
admet-850	75	45	immediate	immediate	ADJ
admet-850	75	46	release	release	NOUN
admet-850	75	47	tablet	tablet	NOUN
admet-850	75	48	associated	associate	VERB
admet-850	75	49	with	with	ADP
admet-850	75	50	a	a	DET
admet-850	75	51	default	default	NOUN
admet-850	75	52	gastric	gastric	ADJ
admet-850	75	53	transit	transit	NOUN
admet-850	75	54	time	time	NOUN
admet-850	75	55	of	of	ADP
admet-850	75	56	15	15	NUM
admet-850	75	57	min	min	NOUN
admet-850	75	58	.	.	PROPN
admet-850	75	59	gastrointestinal	gastrointestinal	ADJ
admet-850	75	60	absorption	absorption	NOUN
admet-850	75	61	rate	rate	NOUN
admet-850	75	62	in	in	ADP
admet-850	75	63	the	the	DET
admet-850	75	64	acat	acat	ADJ
admet-850	75	65	model	model	NOUN
admet-850	75	66	is	be	AUX
admet-850	75	67	estimated	estimate	VERB
admet-850	75	68	over	over	ADP
admet-850	75	69	a	a	DET
admet-850	75	70	physiological	physiological	ADJ
admet-850	75	71	ph	ph	NOUN
admet-850	75	72	range	range	NOUN
admet-850	75	73	of	of	ADP
admet-850	75	74	1.3	1.3	NUM
admet-850	75	75	–	–	PUNCT
admet-850	75	76	6.8	6.8	NUM
admet-850	75	77	employing	employ	VERB
admet-850	75	78	an	an	DET
admet-850	75	79	absorption	absorption	NOUN
admet-850	75	80	scale	scale	NOUN
admet-850	75	81	factor	factor	NOUN
admet-850	75	82	logd	logd	NOUN
admet-850	75	83	model	model	NOUN
admet-850	75	84	,	,	PUNCT
admet-850	75	85	which	which	PRON
admet-850	75	86	considers	consider	VERB
admet-850	75	87	regional	regional	ADJ
admet-850	75	88	permeability	permeability	NOUN
admet-850	75	89	according	accord	VERB
admet-850	75	90	to	to	AUX
admet-850	75	91	predicted	predict	VERB
admet-850	75	92	physiological	physiological	ADJ
admet-850	75	93	changes	change	NOUN
admet-850	75	94	in	in	ADP
admet-850	75	95	transand	transand	ADJ
admet-850	75	96	paracellular	paracellular	ADJ
admet-850	75	97	transport	transport	NOUN
admet-850	75	98	,	,	PUNCT
admet-850	75	99	anatomical	anatomical	ADJ
admet-850	75	100	changes	change	NOUN
admet-850	75	101	in	in	ADP
admet-850	75	102	surface	surface	NOUN
admet-850	75	103	area	area	NOUN
admet-850	75	104	due	due	ADP
admet-850	75	105	to	to	ADP
admet-850	75	106	the	the	DET
admet-850	75	107	presence	presence	NOUN
admet-850	75	108	of	of	ADP
admet-850	75	109	villi	villi	NOUN
admet-850	75	110	and	and	CCONJ
admet-850	75	111	microvilli	microvilli	NOUN
admet-850	75	112	,	,	PUNCT
admet-850	75	113	and	and	CCONJ
admet-850	75	114	gastrointestinal	gastrointestinal	ADJ
admet-850	75	115	ph	ph	NOUN
admet-850	75	116	gradient	gradient	NOUN
admet-850	75	117	.	.	PUNCT
admet-850	76	1	a	a	DET
admet-850	76	2	summary	summary	NOUN
admet-850	76	3	of	of	ADP
admet-850	76	4	general	general	ADJ
admet-850	76	5	input	input	NOUN
admet-850	76	6	parameters	parameter	NOUN
admet-850	76	7	used	use	VERB
admet-850	76	8	for	for	ADP
admet-850	76	9	this	this	DET
admet-850	76	10	pbpk	pbpk	NOUN
admet-850	76	11	modeling	modeling	NOUN
admet-850	76	12	approach	approach	NOUN
admet-850	76	13	is	be	AUX
admet-850	76	14	provided	provide	VERB
admet-850	76	15	in	in	ADP
admet-850	76	16	table	table	NOUN
admet-850	76	17	2	2	NUM
admet-850	76	18	.	.	PUNCT
admet-850	76	19	api	api	NOUN
admet-850	76	20	-	-	PUNCT
admet-850	76	21	specific	specific	ADJ
admet-850	76	22	input	input	NOUN
admet-850	76	23	parameters	parameter	NOUN
admet-850	76	24	were	be	AUX
admet-850	76	25	generated	generate	VERB
admet-850	76	26	in	in	ADP
admet-850	76	27	silico	silico	NOUN
admet-850	76	28	using	use	VERB
admet-850	76	29	the	the	DET
admet-850	76	30	admet	admet	PROPN
admet-850	76	31	predictor	predictor	NOUN
admet-850	76	32	©	©	PROPN
admet-850	76	33	v9.5.0.0	v9.5.0.0	PROPN
admet-850	76	34	(	(	PUNCT
admet-850	76	35	simulations	simulation	NOUN
admet-850	76	36	plus	plus	NOUN
admet-850	76	37	,	,	PUNCT
admet-850	76	38	inc	inc	PROPN
admet-850	76	39	.	.	PROPN
admet-850	76	40	,	,	PUNCT
admet-850	76	41	lancaster	lancaster	PROPN
admet-850	76	42	,	,	PUNCT
admet-850	76	43	ca	ca	NOUN
admet-850	76	44	)	)	PUNCT
admet-850	76	45	.	.	PUNCT
admet-850	77	1	to	to	PART
admet-850	77	2	compare	compare	VERB
admet-850	77	3	in	in	ADP
admet-850	77	4	silico	silico	NOUN
admet-850	77	5	predicted	predict	VERB
admet-850	77	6	fa	fa	NUM
admet-850	77	7	values	value	NOUN
admet-850	77	8	for	for	ADP
admet-850	77	9	gastrointestinal	gastrointestinal	ADJ
admet-850	77	10	absorption	absorption	NOUN
admet-850	77	11	in	in	ADP
admet-850	77	12	humans	human	NOUN
admet-850	77	13	to	to	PART
admet-850	77	14	clinically	clinically	ADV
admet-850	77	15	determined	determine	VERB
admet-850	77	16	oral	oral	ADJ
admet-850	77	17	bioavailability	bioavailability	NOUN
admet-850	77	18	data	datum	NOUN
admet-850	77	19	indicative	indicative	ADJ
admet-850	77	20	of	of	ADP
admet-850	77	21	the	the	DET
admet-850	77	22	fraction	fraction	NOUN
admet-850	77	23	absorbed	absorb	VERB
admet-850	77	24	in	in	ADP
admet-850	77	25	vivo	vivo	NOUN
admet-850	77	26	,	,	PUNCT
admet-850	77	27	a	a	DET
admet-850	77	28	literature	literature	NOUN
admet-850	77	29	search	search	NOUN
admet-850	77	30	was	be	AUX
admet-850	77	31	performed	perform	VERB
admet-850	77	32	in	in	ADP
admet-850	77	33	the	the	DET
admet-850	77	34	pubmed	pubmed	PROPN
admet-850	77	35	database	database	PROPN
admet-850	77	36	(	(	PUNCT
admet-850	77	37	www.ncbi.nlm.nih.gov	www.ncbi.nlm.nih.gov	ADV
admet-850	77	38	)	)	PUNCT
admet-850	77	39	using	use	VERB
admet-850	77	40	the	the	DET
admet-850	77	41	international	international	ADJ
admet-850	77	42	nonproprietary	nonproprietary	ADJ
admet-850	77	43	name	name	NOUN
admet-850	77	44	of	of	ADP
admet-850	77	45	the	the	DET
admet-850	77	46	selected	select	VERB
admet-850	77	47	api	api	NOUN
admet-850	77	48	in	in	ADP
admet-850	77	49	combination	combination	NOUN
admet-850	77	50	with	with	ADP
admet-850	77	51	one	one	NUM
admet-850	77	52	or	or	CCONJ
admet-850	77	53	more	more	ADJ
admet-850	77	54	of	of	ADP
admet-850	77	55	the	the	DET
admet-850	77	56	following	follow	VERB
admet-850	77	57	search	search	NOUN
admet-850	77	58	terms	term	NOUN
admet-850	77	59	:	:	PUNCT
admet-850	77	60	absorption	absorption	NOUN
admet-850	77	61	,	,	PUNCT
admet-850	77	62	bcs	bc	NOUN
admet-850	77	63	,	,	PUNCT
admet-850	77	64	bioavailability	bioavailability	NOUN
admet-850	77	65	,	,	PUNCT
admet-850	77	66	fraction	fraction	NOUN
admet-850	77	67	absorbed	absorb	VERB
admet-850	77	68	,	,	PUNCT
admet-850	77	69	gastrointestinal	gastrointestinal	ADJ
admet-850	77	70	,	,	PUNCT
admet-850	77	71	isotope	isotope	NOUN
admet-850	77	72	,	,	PUNCT
admet-850	77	73	mass	mass	NOUN
admet-850	77	74	balance	balance	NOUN
admet-850	77	75	,	,	PUNCT
admet-850	77	76	oral	oral	ADJ
admet-850	77	77	,	,	PUNCT
admet-850	77	78	and	and	CCONJ
admet-850	77	79	pharmacokinetics	pharmacokinetic	NOUN
admet-850	77	80	.	.	PUNCT
admet-850	78	1	moreover	moreover	ADV
admet-850	78	2	,	,	PUNCT
admet-850	78	3	publicly	publicly	ADV
admet-850	78	4	available	available	ADJ
admet-850	78	5	documents	document	NOUN
admet-850	78	6	associated	associate	VERB
admet-850	78	7	with	with	ADP
admet-850	78	8	regulatory	regulatory	ADJ
admet-850	78	9	approvals	approval	NOUN
admet-850	78	10	of	of	ADP
admet-850	78	11	originator	originator	NOUN
admet-850	78	12	and	and	CCONJ
admet-850	78	13	generic	generic	ADJ
admet-850	78	14	drug	drug	NOUN
admet-850	78	15	products	product	NOUN
admet-850	78	16	for	for	ADP
admet-850	78	17	the	the	DET
admet-850	78	18	respective	respective	ADJ
admet-850	78	19	api	api	NOUN
admet-850	78	20	were	be	AUX
admet-850	78	21	consulted	consult	VERB
admet-850	78	22	to	to	PART
admet-850	78	23	collect	collect	VERB
admet-850	78	24	pertinent	pertinent	NOUN
admet-850	78	25	in	in	ADP
admet-850	78	26	vivo	vivo	ADJ
admet-850	78	27	pharmacokinetic	pharmacokinetic	ADJ
admet-850	78	28	information	information	NOUN
admet-850	78	29	from	from	ADP
admet-850	78	30	human	human	ADJ
admet-850	78	31	trials	trial	NOUN
admet-850	78	32	.	.	PUNCT
admet-850	79	1	statistical	statistical	ADJ
admet-850	79	2	analysis	analysis	NOUN
admet-850	79	3	all	all	DET
admet-850	79	4	experiments	experiment	NOUN
admet-850	79	5	were	be	AUX
admet-850	79	6	carried	carry	VERB
admet-850	79	7	out	out	ADP
admet-850	79	8	at	at	ADP
admet-850	79	9	least	least	ADJ
admet-850	79	10	in	in	ADP
admet-850	79	11	three	three	NUM
admet-850	79	12	independent	independent	ADJ
admet-850	79	13	laboratories	laboratory	NOUN
admet-850	79	14	,	,	PUNCT
admet-850	79	15	and	and	CCONJ
admet-850	79	16	results	result	NOUN
admet-850	79	17	are	be	AUX
admet-850	79	18	reported	report	VERB
admet-850	79	19	as	as	ADP
admet-850	79	20	mean	mean	NOUN
admet-850	79	21	±	±	NUM
admet-850	79	22	standard	standard	ADJ
admet-850	79	23	deviation	deviation	NOUN
admet-850	79	24	(	(	PUNCT
admet-850	79	25	sd	sd	NOUN
admet-850	79	26	)	)	PUNCT
admet-850	79	27	.	.	PUNCT
admet-850	80	1	coefficients	coefficient	NOUN
admet-850	80	2	of	of	ADP
admet-850	80	3	variation	variation	NOUN
admet-850	80	4	(	(	PUNCT
admet-850	80	5	%	%	INTJ
admet-850	80	6	cv	cv	NOUN
admet-850	80	7	)	)	PUNCT
admet-850	80	8	were	be	AUX
admet-850	80	9	calculated	calculate	VERB
admet-850	80	10	as	as	ADP
admet-850	80	11	100×sd	100×sd	ADJ
admet-850	80	12	/	/	SYM
admet-850	80	13	mean	mean	NOUN
admet-850	80	14	.	.	PUNCT
admet-850	81	1	statistically	statistically	ADV
admet-850	81	2	significant	significant	ADJ
admet-850	81	3	differences	difference	NOUN
admet-850	81	4	(	(	PUNCT
admet-850	81	5	p<0.05	p<0.05	NOUN
admet-850	81	6	)	)	PUNCT
admet-850	81	7	between	between	ADP
admet-850	81	8	groups	group	NOUN
admet-850	81	9	were	be	AUX
admet-850	81	10	evaluated	evaluate	VERB
admet-850	81	11	using	use	VERB
admet-850	81	12	unpaired	unpaired	ADJ
admet-850	81	13	student	student	NOUN
admet-850	81	14	’s	’s	PART
admet-850	81	15	t	t	PROPN
admet-850	81	16	-	-	PUNCT
admet-850	81	17	test	test	NOUN
admet-850	81	18	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	81	19	http://www.ncbi.nlm.nih.gov/	http://www.ncbi.nlm.nih.gov/	PROPN
admet-850	82	1	valeria	valeria	PROPN
admet-850	82	2	gigante	gigante	PROPN
admet-850	82	3	et	et	PROPN
admet-850	82	4	al	al	PROPN
admet-850	82	5	.	.	PROPN
admet-850	82	6	admet	admet	PROPN
admet-850	82	7	&	&	CCONJ
admet-850	82	8	dmpk	dmpk	PROPN
admet-850	82	9	9(1	9(1	NUM
admet-850	82	10	)	)	PUNCT
admet-850	82	11	(	(	PUNCT
admet-850	82	12	2021	2021	NUM
admet-850	82	13	)	)	PUNCT
admet-850	82	14	23	23	NUM
admet-850	82	15	-	-	SYM
admet-850	82	16	39	39	NUM
admet-850	82	17	28	28	NUM
admet-850	82	18	or	or	CCONJ
admet-850	82	19	one	one	NUM
admet-850	82	20	-	-	PUNCT
admet-850	82	21	way	way	NOUN
admet-850	82	22	analysis	analysis	NOUN
admet-850	82	23	of	of	ADP
admet-850	82	24	variance	variance	NOUN
admet-850	82	25	(	(	PUNCT
admet-850	82	26	anova	anova	PROPN
admet-850	82	27	)	)	PUNCT
admet-850	82	28	where	where	SCONJ
admet-850	82	29	appropriate	appropriate	ADJ
admet-850	82	30	(	(	PUNCT
admet-850	82	31	microsoft	microsoft	PROPN
admet-850	82	32	excel	excel	VERB
admet-850	82	33	2010	2010	NUM
admet-850	82	34	,	,	PUNCT
admet-850	82	35	microsoft	microsoft	PROPN
admet-850	82	36	,	,	PUNCT
admet-850	82	37	redmond	redmond	PROPN
admet-850	82	38	,	,	PUNCT
admet-850	82	39	wa	wa	NOUN
admet-850	82	40	)	)	PUNCT
admet-850	82	41	.	.	PUNCT
admet-850	83	1	table	table	NOUN
admet-850	83	2	2	2	NUM
admet-850	83	3	.	.	PUNCT
admet-850	83	4	general	general	ADJ
admet-850	83	5	formulation	formulation	NOUN
admet-850	83	6	and	and	CCONJ
admet-850	83	7	pbpk	pbpk	NOUN
admet-850	83	8	simulation	simulation	NOUN
admet-850	83	9	parameters	parameter	NOUN
admet-850	83	10	used	use	VERB
admet-850	83	11	as	as	ADP
admet-850	83	12	model	model	NOUN
admet-850	83	13	input	input	NOUN
admet-850	83	14	variables	variable	NOUN
admet-850	83	15	in	in	ADP
admet-850	83	16	gastroplus	gastroplus	ADJ
admet-850	83	17	®	®	NOUN
admet-850	83	18	input	input	NOUN
admet-850	83	19	parameter	parameter	NOUN
admet-850	83	20	value	value	NOUN
admet-850	83	21	dosage	dosage	NOUN
admet-850	83	22	form	form	NOUN
admet-850	83	23	dose	dose	NOUN
admet-850	83	24	dose	dose	NOUN
admet-850	83	25	volume	volume	NOUN
admet-850	83	26	[	[	X
admet-850	83	27	ml	ml	X
admet-850	83	28	]	]	X
admet-850	83	29	mean	mean	ADJ
admet-850	83	30	precipitation	precipitation	NOUN
admet-850	83	31	time	time	NOUN
admet-850	84	1	[	[	X
admet-850	84	2	s	s	X
admet-850	84	3	]	]	X
admet-850	84	4	drug	drug	NOUN
admet-850	84	5	particle	particle	NOUN
admet-850	84	6	density	density	NOUN
admet-850	85	1	[	[	X
admet-850	85	2	g	g	NOUN
admet-850	85	3	/	/	SYM
admet-850	85	4	ml	ml	NOUN
admet-850	85	5	]	]	PUNCT
admet-850	85	6	mean	mean	ADJ
admet-850	85	7	particle	particle	NOUN
admet-850	85	8	radius	radius	NOUN
admet-850	85	9	[	[	X
admet-850	85	10	µm	µm	NOUN
admet-850	85	11	]	]	X
admet-850	85	12	number	number	NOUN
admet-850	85	13	of	of	ADP
admet-850	85	14	bins	bin	NOUN
admet-850	85	15	shape	shape	NOUN
admet-850	85	16	factor	factor	NOUN
admet-850	85	17	dissolution	dissolution	NOUN
admet-850	85	18	model	model	PROPN
admet-850	85	19	bile	bile	NOUN
admet-850	85	20	salt	salt	NOUN
admet-850	85	21	effect	effect	VERB
admet-850	85	22	pbpk	pbpk	NOUN
admet-850	85	23	model	model	NOUN
admet-850	85	24	small	small	ADJ
admet-850	85	25	intestine	intestine	NOUN
admet-850	85	26	transit	transit	NOUN
admet-850	85	27	time	time	NOUN
admet-850	86	1	[	[	X
admet-850	86	2	h	h	X
admet-850	86	3	]	]	X
admet-850	86	4	asf	asf	NOUN
admet-850	86	5	model	model	NOUN
admet-850	86	6	paracellular	paracellular	ADJ
admet-850	86	7	model	model	NOUN
admet-850	86	8	biliary	biliary	NOUN
admet-850	86	9	clearance	clearance	NOUN
admet-850	86	10	fraction	fraction	NOUN
admet-850	86	11	simulation	simulation	NOUN
admet-850	86	12	mode	mode	PROPN
admet-850	86	13	simulation	simulation	PROPN
admet-850	86	14	time	time	NOUN
admet-850	86	15	[	[	X
admet-850	86	16	h	h	X
admet-850	86	17	]	]	X
admet-850	86	18	immediate	immediate	ADJ
admet-850	86	19	release	release	NOUN
admet-850	86	20	tablet	tablet	NOUN
admet-850	86	21	highest	high	ADJ
admet-850	86	22	therapeutic	therapeutic	ADJ
admet-850	86	23	dose	dose	NOUN
admet-850	86	24	/	/	SYM
admet-850	86	25	formulation	formulation	NOUN
admet-850	86	26	strength	strength	NOUN
admet-850	86	27	250	250	NUM
admet-850	86	28	900	900	NUM
admet-850	86	29	1.2	1.2	NUM
admet-850	86	30	25	25	NUM
admet-850	86	31	1	1	NUM
admet-850	86	32	1	1	NUM
admet-850	86	33	johnson	johnson	PROPN
admet-850	86	34	off	off	ADP
admet-850	86	35	human	human	PROPN
admet-850	86	36	fasted	fast	VERB
admet-850	86	37	(	(	PUNCT
admet-850	86	38	male	male	ADJ
admet-850	86	39	,	,	PUNCT
admet-850	86	40	30	30	NUM
admet-850	86	41	years	year	NOUN
admet-850	86	42	,	,	PUNCT
admet-850	86	43	70	70	NUM
admet-850	86	44	kg	kg	NOUN
admet-850	86	45	)	)	PUNCT
admet-850	86	46	3.2	3.2	NUM
admet-850	86	47	optlogd	optlogd	NOUN
admet-850	86	48	model	model	NOUN
admet-850	86	49	sa	sa	PROPN
admet-850	86	50	/	/	SYM
admet-850	86	51	v	v	PROPN
admet-850	86	52	6.1	6.1	NUM
admet-850	86	53	zhimin	zhimin	NOUN
admet-850	86	54	0	0	NUM
admet-850	86	55	single	single	ADJ
admet-850	86	56	24	24	NUM
admet-850	86	57	results	result	NOUN
admet-850	86	58	and	and	CCONJ
admet-850	86	59	discussion	discussion	NOUN
admet-850	86	60	complexities	complexity	NOUN
admet-850	86	61	of	of	ADP
admet-850	86	62	solubility	solubility	NOUN
admet-850	86	63	measurements	measurement	VERB
admet-850	86	64	a	a	DET
admet-850	86	65	distinct	distinct	ADJ
admet-850	86	66	feature	feature	NOUN
admet-850	86	67	of	of	ADP
admet-850	86	68	the	the	PRON
admet-850	86	69	who	who	PRON
admet-850	86	70	bcs	bcs	VERB
admet-850	86	71	when	when	SCONJ
admet-850	86	72	compared	compare	VERB
admet-850	86	73	to	to	ADP
admet-850	86	74	other	other	ADJ
admet-850	86	75	bcs	bcs	NOUN
admet-850	86	76	classification	classification	NOUN
admet-850	86	77	systems	system	NOUN
admet-850	86	78	as	as	SCONJ
admet-850	86	79	defined	define	VERB
admet-850	86	80	by	by	ADP
admet-850	86	81	various	various	ADJ
admet-850	86	82	regional	regional	ADJ
admet-850	86	83	regulatory	regulatory	ADJ
admet-850	86	84	authorities	authority	NOUN
admet-850	86	85	is	be	AUX
admet-850	86	86	that	that	SCONJ
admet-850	86	87	the	the	DET
admet-850	86	88	who	who	PRON
admet-850	86	89	classification	classification	NOUN
admet-850	86	90	centers	center	NOUN
admet-850	86	91	on	on	ADP
admet-850	86	92	the	the	DET
admet-850	86	93	highest	high	ADJ
admet-850	86	94	single	single	ADJ
admet-850	86	95	oral	oral	ADJ
admet-850	86	96	therapeutic	therapeutic	ADJ
admet-850	86	97	dose	dose	NOUN
admet-850	86	98	of	of	ADP
admet-850	86	99	each	each	DET
admet-850	86	100	apis	apis	NOUN
admet-850	86	101	(	(	PUNCT
admet-850	86	102	as	as	SCONJ
admet-850	86	103	recommended	recommend	VERB
admet-850	86	104	by	by	ADP
admet-850	86	105	the	the	DET
admet-850	86	106	approved	approve	VERB
admet-850	86	107	label	label	NOUN
admet-850	86	108	/	/	SYM
admet-850	86	109	summary	summary	NOUN
admet-850	86	110	of	of	ADP
admet-850	86	111	product	product	NOUN
admet-850	86	112	characteristics	characteristic	NOUN
admet-850	86	113	of	of	ADP
admet-850	86	114	the	the	DET
admet-850	86	115	originator	originator	NOUN
admet-850	86	116	)	)	PUNCT
admet-850	86	117	to	to	PART
admet-850	86	118	estimate	estimate	VERB
admet-850	86	119	the	the	DET
admet-850	86	120	dsv	dsv	PROPN
admet-850	86	121	.	.	PUNCT
admet-850	87	1	the	the	DET
admet-850	87	2	rationale	rationale	NOUN
admet-850	87	3	for	for	ADP
admet-850	87	4	this	this	DET
admet-850	87	5	definition	definition	NOUN
admet-850	87	6	is	be	AUX
admet-850	87	7	that	that	SCONJ
admet-850	87	8	bcs	bcs	NOUN
admet-850	87	9	classification	classification	NOUN
admet-850	87	10	is	be	AUX
admet-850	87	11	mimicking	mimic	VERB
admet-850	87	12	more	more	ADV
admet-850	87	13	closely	closely	ADV
admet-850	87	14	real	real	ADJ
admet-850	87	15	life	life	NOUN
admet-850	87	16	conditions	condition	NOUN
admet-850	87	17	and	and	CCONJ
admet-850	87	18	corresponds	correspond	VERB
admet-850	87	19	to	to	ADP
admet-850	87	20	the	the	DET
admet-850	87	21	“	"	PUNCT
admet-850	87	22	worst	bad	ADJ
admet-850	87	23	case	case	NOUN
admet-850	87	24	scenario	scenario	NOUN
admet-850	87	25	”	"	PUNCT
admet-850	87	26	when	when	SCONJ
admet-850	87	27	patients	patient	NOUN
admet-850	87	28	are	be	AUX
admet-850	87	29	taking	take	VERB
admet-850	87	30	the	the	DET
admet-850	87	31	therapeutic	therapeutic	ADJ
admet-850	87	32	oral	oral	ADJ
admet-850	87	33	dose	dose	NOUN
admet-850	87	34	prescribed	prescribe	VERB
admet-850	87	35	.	.	PUNCT
admet-850	88	1	moreover	moreover	ADV
admet-850	88	2	,	,	PUNCT
admet-850	88	3	a	a	DET
admet-850	88	4	focus	focus	NOUN
admet-850	88	5	on	on	ADP
admet-850	88	6	the	the	DET
admet-850	88	7	highest	high	ADJ
admet-850	88	8	single	single	ADJ
admet-850	88	9	oral	oral	ADJ
admet-850	88	10	dose	dose	NOUN
admet-850	88	11	provides	provide	VERB
admet-850	88	12	the	the	DET
admet-850	88	13	necessary	necessary	ADJ
admet-850	88	14	flexibility	flexibility	NOUN
admet-850	88	15	to	to	PART
admet-850	88	16	consider	consider	VERB
admet-850	88	17	different	different	ADJ
admet-850	88	18	strengths	strength	NOUN
admet-850	88	19	available	available	ADJ
admet-850	88	20	on	on	ADP
admet-850	88	21	the	the	DET
admet-850	88	22	market	market	NOUN
admet-850	88	23	when	when	SCONJ
admet-850	88	24	regulatory	regulatory	ADJ
admet-850	88	25	decisions	decision	NOUN
admet-850	88	26	regarding	regard	VERB
admet-850	88	27	a	a	DET
admet-850	88	28	biowaiver	biowaiver	NOUN
admet-850	88	29	are	be	AUX
admet-850	88	30	discussed	discuss	VERB
admet-850	88	31	.	.	PUNCT
admet-850	89	1	overall	overall	ADV
admet-850	89	2	,	,	PUNCT
admet-850	89	3	these	these	DET
admet-850	89	4	measures	measure	NOUN
admet-850	89	5	are	be	AUX
admet-850	89	6	consistent	consistent	ADJ
admet-850	89	7	with	with	ADP
admet-850	89	8	the	the	PRON
admet-850	89	9	who	who	PRON
admet-850	89	10	’s	’	VERB
admet-850	89	11	priority	priority	NOUN
admet-850	89	12	on	on	ADP
admet-850	89	13	facilitating	facilitate	VERB
admet-850	89	14	access	access	NOUN
admet-850	89	15	to	to	ADP
admet-850	89	16	affordable	affordable	ADJ
admet-850	89	17	medicines	medicine	NOUN
admet-850	89	18	globally	globally	ADV
admet-850	89	19	.	.	PUNCT
admet-850	90	1	in	in	ADP
admet-850	90	2	general	general	ADJ
admet-850	90	3	,	,	PUNCT
admet-850	90	4	samples	sample	NOUN
admet-850	90	5	are	be	AUX
admet-850	90	6	expected	expect	VERB
admet-850	90	7	to	to	PART
admet-850	90	8	reach	reach	VERB
admet-850	90	9	equilibrium	equilibrium	NOUN
admet-850	90	10	within	within	ADP
admet-850	90	11	24	24	NUM
admet-850	90	12	hours	hour	NOUN
admet-850	90	13	.	.	PUNCT
admet-850	91	1	however	however	ADV
admet-850	91	2	,	,	PUNCT
admet-850	91	3	the	the	DET
admet-850	91	4	time	time	NOUN
admet-850	91	5	required	require	VERB
admet-850	91	6	to	to	PART
admet-850	91	7	arrive	arrive	VERB
admet-850	91	8	at	at	ADP
admet-850	91	9	equilibrium	equilibrium	NOUN
admet-850	91	10	between	between	ADP
admet-850	91	11	solid	solid	ADJ
admet-850	91	12	and	and	CCONJ
admet-850	91	13	dissolved	dissolve	VERB
admet-850	91	14	api	api	NOUN
admet-850	91	15	may	may	AUX
admet-850	91	16	be	be	AUX
admet-850	91	17	influenced	influence	VERB
admet-850	91	18	by	by	ADP
admet-850	91	19	various	various	ADJ
admet-850	91	20	experimental	experimental	ADJ
admet-850	91	21	factors	factor	NOUN
admet-850	91	22	ranging	range	VERB
admet-850	91	23	from	from	ADP
admet-850	91	24	intrinsic	intrinsic	ADJ
admet-850	91	25	api	api	NOUN
admet-850	91	26	characteristics	characteristic	NOUN
admet-850	91	27	,	,	PUNCT
admet-850	91	28	excess	excess	NOUN
admet-850	91	29	of	of	ADP
admet-850	91	30	solid	solid	ADJ
admet-850	91	31	included	include	VERB
admet-850	91	32	,	,	PUNCT
admet-850	91	33	to	to	ADP
admet-850	91	34	the	the	DET
admet-850	91	35	type	type	NOUN
admet-850	91	36	and	and	CCONJ
admet-850	91	37	speed	speed	NOUN
admet-850	91	38	of	of	ADP
admet-850	91	39	agitation	agitation	NOUN
admet-850	91	40	method	method	NOUN
admet-850	91	41	used	use	VERB
admet-850	91	42	[	[	X
admet-850	91	43	12	12	NUM
admet-850	91	44	]	]	PUNCT
admet-850	91	45	.	.	PUNCT
admet-850	92	1	this	this	PRON
admet-850	92	2	may	may	AUX
admet-850	92	3	leads	lead	VERB
admet-850	92	4	to	to	ADP
admet-850	92	5	long	long	ADJ
admet-850	92	6	dissolution	dissolution	PROPN
admet-850	92	7	times	time	NOUN
admet-850	92	8	until	until	SCONJ
admet-850	92	9	saturation	saturation	NOUN
admet-850	92	10	is	be	AUX
admet-850	92	11	reached	reach	VERB
admet-850	92	12	that	that	PRON
admet-850	92	13	carry	carry	VERB
admet-850	92	14	the	the	DET
admet-850	92	15	risk	risk	NOUN
admet-850	92	16	of	of	ADP
admet-850	92	17	introducing	introduce	VERB
admet-850	92	18	structural	structural	ADJ
admet-850	92	19	changes	change	NOUN
admet-850	92	20	in	in	ADP
admet-850	92	21	the	the	DET
admet-850	92	22	drug	drug	NOUN
admet-850	92	23	substance	substance	NOUN
admet-850	92	24	when	when	SCONJ
admet-850	92	25	in	in	ADP
admet-850	92	26	contact	contact	NOUN
admet-850	92	27	with	with	ADP
admet-850	92	28	buffers	buffer	NOUN
admet-850	92	29	solutions	solution	NOUN
admet-850	92	30	,	,	PUNCT
admet-850	92	31	including	include	VERB
admet-850	92	32	transition	transition	NOUN
admet-850	92	33	into	into	ADP
admet-850	92	34	a	a	DET
admet-850	92	35	different	different	ADJ
admet-850	92	36	polymorphic	polymorphic	ADJ
admet-850	92	37	state	state	NOUN
admet-850	92	38	,	,	PUNCT
admet-850	92	39	salt	salt	NOUN
admet-850	92	40	or	or	CCONJ
admet-850	92	41	solvate	solvate	NOUN
admet-850	92	42	.	.	PUNCT
admet-850	93	1	in	in	ADP
admet-850	93	2	solution	solution	NOUN
admet-850	93	3	,	,	PUNCT
admet-850	93	4	salt	salt	NOUN
admet-850	93	5	forms	form	NOUN
admet-850	93	6	are	be	AUX
admet-850	93	7	more	more	ADV
admet-850	93	8	likely	likely	ADJ
admet-850	93	9	to	to	PART
admet-850	93	10	recrystallize	recrystallize	VERB
admet-850	93	11	resulting	result	VERB
admet-850	93	12	in	in	ADP
admet-850	93	13	highly	highly	ADV
admet-850	93	14	stable	stable	ADJ
admet-850	93	15	molecular	molecular	ADJ
admet-850	93	16	configurations	configuration	NOUN
admet-850	93	17	(	(	PUNCT
admet-850	93	18	i.e.	i.e.	X
admet-850	93	19	,	,	PUNCT
admet-850	93	20	free	free	ADJ
admet-850	93	21	forms	form	NOUN
admet-850	93	22	)	)	PUNCT
admet-850	93	23	with	with	ADP
admet-850	93	24	significantly	significantly	ADV
admet-850	93	25	altered	alter	VERB
admet-850	93	26	dissolution	dissolution	NOUN
admet-850	93	27	properties	property	NOUN
admet-850	93	28	.	.	PUNCT
admet-850	94	1	for	for	ADP
admet-850	94	2	ionized	ionized	ADJ
admet-850	94	3	molecules	molecule	NOUN
admet-850	94	4	,	,	PUNCT
admet-850	94	5	in	in	ADP
admet-850	94	6	addition	addition	NOUN
admet-850	94	7	,	,	PUNCT
admet-850	94	8	the	the	DET
admet-850	94	9	propensity	propensity	NOUN
admet-850	94	10	for	for	ADP
admet-850	94	11	self	self	NOUN
admet-850	94	12	-	-	PUNCT
admet-850	94	13	aggregation	aggregation	NOUN
admet-850	94	14	and/or	and/or	CCONJ
admet-850	94	15	complexation	complexation	NOUN
admet-850	94	16	is	be	AUX
admet-850	94	17	increased	increase	VERB
admet-850	94	18	while	while	SCONJ
admet-850	94	19	in	in	ADP
admet-850	94	20	contact	contact	NOUN
admet-850	94	21	with	with	ADP
admet-850	94	22	buffer	buffer	NOUN
admet-850	94	23	components	component	NOUN
admet-850	94	24	.	.	PUNCT
admet-850	95	1	the	the	DET
admet-850	95	2	conventional	conventional	ADJ
admet-850	95	3	shake	shake	NOUN
admet-850	95	4	-	-	PUNCT
admet-850	95	5	flask	flask	NOUN
admet-850	95	6	method	method	NOUN
admet-850	95	7	represents	represent	VERB
admet-850	95	8	the	the	DET
admet-850	95	9	“	"	PUNCT
admet-850	95	10	gold	gold	ADJ
admet-850	95	11	standard	standard	NOUN
admet-850	95	12	”	"	PUNCT
admet-850	95	13	for	for	ADP
admet-850	95	14	solubility	solubility	NOUN
admet-850	95	15	assessment	assessment	NOUN
admet-850	95	16	as	as	SCONJ
admet-850	95	17	it	it	PRON
admet-850	95	18	is	be	AUX
admet-850	95	19	simple	simple	ADJ
admet-850	95	20	and	and	CCONJ
admet-850	95	21	easy	easy	ADJ
admet-850	95	22	to	to	PART
admet-850	95	23	perform	perform	VERB
admet-850	95	24	and	and	CCONJ
admet-850	95	25	only	only	ADV
admet-850	95	26	requires	require	VERB
admet-850	95	27	inexpensive	inexpensive	ADJ
admet-850	95	28	instrumentation	instrumentation	NOUN
admet-850	95	29	.	.	PUNCT
admet-850	96	1	when	when	SCONJ
admet-850	96	2	executed	execute	VERB
admet-850	96	3	according	accord	VERB
admet-850	96	4	to	to	ADP
admet-850	96	5	a	a	DET
admet-850	96	6	well	well	ADV
admet-850	96	7	-	-	PUNCT
admet-850	96	8	designed	design	VERB
admet-850	96	9	protocol	protocol	NOUN
admet-850	96	10	,	,	PUNCT
admet-850	96	11	it	it	PRON
admet-850	96	12	generally	generally	ADV
admet-850	96	13	results	result	VERB
admet-850	96	14	in	in	ADP
admet-850	96	15	high	high	ADJ
admet-850	96	16	quality	quality	NOUN
admet-850	96	17	data	datum	NOUN
admet-850	96	18	,	,	PUNCT
admet-850	96	19	with	with	SCONJ
admet-850	96	20	standard	standard	ADJ
admet-850	96	21	deviation	deviation	NOUN
admet-850	96	22	≤5	≤5	VERB
admet-850	96	23	%	%	NOUN
admet-850	96	24	.	.	PUNCT
admet-850	97	1	however	however	ADV
admet-850	97	2	,	,	PUNCT
admet-850	97	3	the	the	DET
admet-850	97	4	shake	shake	NOUN
admet-850	97	5	-	-	PUNCT
admet-850	97	6	flask	flask	NOUN
admet-850	97	7	method	method	NOUN
admet-850	97	8	is	be	AUX
admet-850	97	9	also	also	ADV
admet-850	97	10	timeand	timeand	ADJ
admet-850	97	11	labor	labor	NOUN
admet-850	97	12	-	-	PUNCT
admet-850	97	13	intensive	intensive	ADJ
admet-850	97	14	and	and	CCONJ
admet-850	97	15	may	may	AUX
admet-850	97	16	consume	consume	VERB
admet-850	97	17	significant	significant	ADJ
admet-850	97	18	amounts	amount	NOUN
admet-850	97	19	of	of	ADP
admet-850	97	20	drug	drug	NOUN
admet-850	97	21	substance	substance	NOUN
admet-850	97	22	in	in	ADP
admet-850	97	23	order	order	NOUN
admet-850	97	24	to	to	PART
admet-850	97	25	measure	measure	VERB
admet-850	97	26	thermodynamic	thermodynamic	ADJ
admet-850	97	27	solubility	solubility	NOUN
admet-850	97	28	of	of	ADP
admet-850	97	29	a	a	DET
admet-850	97	30	highly	highly	ADV
admet-850	97	31	soluble	soluble	ADJ
admet-850	97	32	api	api	NOUN
admet-850	97	33	in	in	ADP
admet-850	97	34	the	the	DET
admet-850	97	35	presence	presence	NOUN
admet-850	97	36	of	of	ADP
admet-850	97	37	its	its	PRON
admet-850	97	38	solid	solid	ADJ
admet-850	97	39	admet	admet	NOUN
admet-850	97	40	&	&	CCONJ
admet-850	97	41	dmpk	dmpk	PROPN
admet-850	97	42	9(1	9(1	NUM
admet-850	97	43	)	)	PUNCT
admet-850	97	44	(	(	PUNCT
admet-850	97	45	2021	2021	NUM
admet-850	97	46	)	)	PUNCT
admet-850	97	47	23	23	NUM
admet-850	97	48	-	-	SYM
admet-850	97	49	39	39	NUM
admet-850	97	50	enhancing	enhance	VERB
admet-850	97	51	robustness	robustness	NOUN
admet-850	97	52	of	of	ADP
admet-850	97	53	the	the	PRON
admet-850	97	54	who	who	PRON
admet-850	97	55	biopharmaceutical	biopharmaceutical	ADJ
admet-850	97	56	classification	classification	NOUN
admet-850	97	57	system	system	NOUN
admet-850	97	58	doi	doi	NOUN
admet-850	97	59	:	:	PUNCT
admet-850	97	60	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	X
admet-850	97	61	29	29	NUM
admet-850	97	62	form	form	NOUN
admet-850	97	63	.	.	PUNCT
admet-850	98	1	to	to	PART
admet-850	98	2	minimize	minimize	VERB
admet-850	98	3	such	such	ADJ
admet-850	98	4	constraints	constraint	NOUN
admet-850	98	5	,	,	PUNCT
admet-850	98	6	the	the	DET
admet-850	98	7	harmonized	harmonized	ADJ
admet-850	98	8	protocol	protocol	NOUN
admet-850	98	9	defines	define	VERB
admet-850	98	10	the	the	DET
admet-850	98	11	highest	high	ADJ
admet-850	98	12	api	api	NOUN
admet-850	98	13	concentration	concentration	NOUN
admet-850	98	14	for	for	ADP
admet-850	98	15	pivotal	pivotal	ADJ
admet-850	98	16	solubility	solubility	NOUN
admet-850	98	17	determination	determination	NOUN
admet-850	98	18	in	in	ADP
admet-850	98	19	this	this	DET
admet-850	98	20	study	study	NOUN
admet-850	98	21	to	to	ADP
admet-850	98	22	a	a	DET
admet-850	98	23	concentration	concentration	NOUN
admet-850	98	24	representing	represent	VERB
admet-850	98	25	at	at	ADV
admet-850	98	26	least	least	ADJ
admet-850	98	27	twice	twice	DET
admet-850	98	28	the	the	DET
admet-850	98	29	highest	high	ADJ
admet-850	98	30	therapeutic	therapeutic	ADJ
admet-850	98	31	dose	dose	NOUN
admet-850	98	32	over	over	ADP
admet-850	98	33	250	250	NUM
admet-850	98	34	ml	ml	NOUN
admet-850	98	35	of	of	ADP
admet-850	98	36	buffer	buffer	NOUN
admet-850	98	37	.	.	PUNCT
admet-850	99	1	consequently	consequently	ADV
admet-850	99	2	,	,	PUNCT
admet-850	99	3	the	the	DET
admet-850	99	4	experimentally	experimentally	ADV
admet-850	99	5	determined	determine	VERB
admet-850	99	6	concentration	concentration	NOUN
admet-850	99	7	value	value	NOUN
admet-850	99	8	does	do	AUX
admet-850	99	9	not	not	PART
admet-850	99	10	represent	represent	VERB
admet-850	99	11	a	a	DET
admet-850	99	12	true	true	ADJ
admet-850	99	13	“	"	PUNCT
admet-850	99	14	equilibrium	equilibrium	NOUN
admet-850	99	15	”	"	PUNCT
admet-850	99	16	solubility	solubility	NOUN
admet-850	99	17	but	but	CCONJ
admet-850	99	18	rather	rather	ADV
admet-850	99	19	assures	assure	VERB
admet-850	99	20	that	that	DET
admet-850	99	21	dsv<1	dsv<1	NOUN
admet-850	99	22	,	,	PUNCT
admet-850	99	23	which	which	PRON
admet-850	99	24	is	be	AUX
admet-850	99	25	compliant	compliant	ADJ
admet-850	99	26	with	with	ADP
admet-850	99	27	the	the	DET
admet-850	99	28	definition	definition	NOUN
admet-850	99	29	of	of	ADP
admet-850	99	30	“	"	PUNCT
admet-850	99	31	high	high	ADJ
admet-850	99	32	solubility	solubility	NOUN
admet-850	99	33	”	"	PUNCT
admet-850	99	34	.	.	PUNCT
admet-850	100	1	the	the	DET
admet-850	100	2	results	result	NOUN
admet-850	100	3	of	of	ADP
admet-850	100	4	this	this	DET
admet-850	100	5	global	global	ADJ
admet-850	100	6	solubility	solubility	NOUN
admet-850	100	7	assessment	assessment	NOUN
admet-850	100	8	for	for	ADP
admet-850	100	9	each	each	DET
admet-850	100	10	api	api	NOUN
admet-850	100	11	are	be	AUX
admet-850	100	12	summarized	summarize	VERB
admet-850	100	13	in	in	ADP
admet-850	100	14	table	table	NOUN
admet-850	100	15	3	3	NUM
admet-850	100	16	.	.	PUNCT
admet-850	101	1	it	it	PRON
admet-850	101	2	is	be	AUX
admet-850	101	3	important	important	ADJ
admet-850	101	4	to	to	PART
admet-850	101	5	re	re	VERB
admet-850	101	6	-	-	VERB
admet-850	101	7	emphasize	emphasize	VERB
admet-850	101	8	that	that	SCONJ
admet-850	101	9	individual	individual	ADJ
admet-850	101	10	laboratories	laboratory	NOUN
admet-850	101	11	did	do	AUX
admet-850	101	12	not	not	PART
admet-850	101	13	attempt	attempt	VERB
admet-850	101	14	to	to	PART
admet-850	101	15	quantify	quantify	VERB
admet-850	101	16	the	the	DET
admet-850	101	17	thermodynamic	thermodynamic	ADJ
admet-850	101	18	equilibrium	equilibrium	NOUN
admet-850	101	19	solubility	solubility	NOUN
admet-850	101	20	(	(	PUNCT
admet-850	101	21	i.e.	i.e.	X
admet-850	101	22	,	,	PUNCT
admet-850	101	23	saturation	saturation	NOUN
admet-850	101	24	concentration	concentration	NOUN
admet-850	101	25	in	in	ADP
admet-850	101	26	the	the	DET
admet-850	101	27	presence	presence	NOUN
admet-850	101	28	of	of	ADP
admet-850	101	29	excess	excess	NOUN
admet-850	101	30	solid	solid	ADJ
admet-850	101	31	)	)	PUNCT
admet-850	101	32	.	.	PUNCT
admet-850	102	1	therefore	therefore	ADV
admet-850	102	2	,	,	PUNCT
admet-850	102	3	for	for	ADP
admet-850	102	4	apis	apis	NOUN
admet-850	102	5	with	with	ADP
admet-850	102	6	high	high	ADJ
admet-850	102	7	solubility	solubility	NOUN
admet-850	102	8	,	,	PUNCT
admet-850	102	9	recorded	record	VERB
admet-850	102	10	values	value	NOUN
admet-850	102	11	were	be	AUX
admet-850	102	12	measured	measure	VERB
admet-850	102	13	after	after	ADP
admet-850	102	14	complete	complete	ADJ
admet-850	102	15	dissolution	dissolution	NOUN
admet-850	102	16	of	of	ADP
admet-850	102	17	the	the	DET
admet-850	102	18	solid	solid	NOUN
admet-850	102	19	.	.	PUNCT
admet-850	103	1	consequently	consequently	ADV
admet-850	103	2	,	,	PUNCT
admet-850	103	3	greater	great	ADJ
admet-850	103	4	variability	variability	NOUN
admet-850	103	5	in	in	ADP
admet-850	103	6	absolute	absolute	ADJ
admet-850	103	7	api	api	NOUN
admet-850	103	8	concentrations	concentration	NOUN
admet-850	103	9	recorded	record	VERB
admet-850	103	10	in	in	ADP
admet-850	103	11	table	table	NOUN
admet-850	103	12	3	3	NUM
admet-850	103	13	under	under	ADP
admet-850	103	14	specified	specify	VERB
admet-850	103	15	ph	ph	ADJ
admet-850	103	16	conditions	condition	NOUN
admet-850	103	17	is	be	AUX
admet-850	103	18	the	the	DET
admet-850	103	19	result	result	NOUN
admet-850	103	20	of	of	ADP
admet-850	103	21	different	different	ADJ
admet-850	103	22	api	api	NOUN
admet-850	103	23	amounts	amount	NOUN
admet-850	103	24	used	use	VERB
admet-850	103	25	for	for	ADP
admet-850	103	26	the	the	DET
admet-850	103	27	solubility	solubility	NOUN
admet-850	103	28	experiments	experiment	NOUN
admet-850	103	29	rather	rather	ADV
admet-850	103	30	than	than	ADP
admet-850	103	31	a	a	DET
admet-850	103	32	demonstration	demonstration	NOUN
admet-850	103	33	of	of	ADP
admet-850	103	34	highly	highly	ADV
admet-850	103	35	variable	variable	ADJ
admet-850	103	36	techniques	technique	NOUN
admet-850	103	37	implemented	implement	VERB
admet-850	103	38	by	by	ADP
admet-850	103	39	the	the	DET
admet-850	103	40	different	different	ADJ
admet-850	103	41	laboratories	laboratory	NOUN
admet-850	103	42	.	.	PUNCT
admet-850	104	1	among	among	ADP
admet-850	104	2	the	the	DET
admet-850	104	3	10	10	NUM
admet-850	104	4	apis	apis	ADJ
admet-850	104	5	that	that	PRON
admet-850	104	6	were	be	AUX
admet-850	104	7	previously	previously	ADV
admet-850	104	8	included	include	VERB
admet-850	104	9	in	in	ADP
admet-850	104	10	the	the	DET
admet-850	104	11	2006	2006	NUM
admet-850	104	12	who	who	PRON
admet-850	104	13	bcs	bc	VERB
admet-850	104	14	,	,	PUNCT
admet-850	104	15	which	which	PRON
admet-850	104	16	was	be	AUX
admet-850	104	17	largely	largely	ADV
admet-850	104	18	based	base	VERB
admet-850	104	19	on	on	ADP
admet-850	104	20	secondary	secondary	ADJ
admet-850	104	21	aqueous	aqueous	ADJ
admet-850	104	22	solubility	solubility	NOUN
admet-850	104	23	references	reference	NOUN
admet-850	104	24	,	,	PUNCT
admet-850	104	25	experimental	experimental	ADJ
admet-850	104	26	values	value	NOUN
admet-850	104	27	reported	report	VERB
admet-850	104	28	from	from	ADP
admet-850	104	29	three	three	NUM
admet-850	104	30	independent	independent	ADJ
admet-850	104	31	laboratories	laboratory	NOUN
admet-850	104	32	unambiguously	unambiguously	ADV
admet-850	104	33	justified	justify	VERB
admet-850	104	34	re	re	NOUN
admet-850	104	35	-	-	NOUN
admet-850	104	36	classification	classification	NOUN
admet-850	104	37	of	of	ADP
admet-850	104	38	aciclovir	aciclovir	PROPN
admet-850	104	39	,	,	PUNCT
admet-850	104	40	amoxicillin	amoxicillin	NOUN
admet-850	104	41	,	,	PUNCT
admet-850	104	42	and	and	CCONJ
admet-850	104	43	ethionamide	ethionamide	ADV
admet-850	104	44	from	from	ADP
admet-850	104	45	a	a	DET
admet-850	104	46	“	"	PUNCT
admet-850	104	47	high	high	ADJ
admet-850	104	48	solubility	solubility	NOUN
admet-850	104	49	”	"	PUNCT
admet-850	104	50	(	(	PUNCT
admet-850	104	51	hs	hs	X
admet-850	104	52	)	)	PUNCT
admet-850	104	53	to	to	ADP
admet-850	104	54	a	a	DET
admet-850	104	55	“	"	PUNCT
admet-850	104	56	low	low	ADJ
admet-850	104	57	solubility	solubility	NOUN
admet-850	104	58	”	"	PUNCT
admet-850	104	59	(	(	PUNCT
admet-850	104	60	ls	ls	PROPN
admet-850	104	61	)	)	PUNCT
admet-850	104	62	drug	drug	NOUN
admet-850	104	63	.	.	PUNCT
admet-850	105	1	the	the	DET
admet-850	105	2	change	change	NOUN
admet-850	105	3	in	in	ADP
admet-850	105	4	classification	classification	NOUN
admet-850	105	5	of	of	ADP
admet-850	105	6	amoxicillin	amoxicillin	PROPN
admet-850	105	7	and	and	CCONJ
admet-850	105	8	aciclovir	aciclovir	PROPN
admet-850	105	9	was	be	AUX
admet-850	105	10	related	relate	VERB
admet-850	105	11	to	to	ADP
admet-850	105	12	the	the	DET
admet-850	105	13	solubility	solubility	NOUN
admet-850	105	14	assessment	assessment	NOUN
admet-850	105	15	performed	perform	VERB
admet-850	105	16	at	at	ADP
admet-850	105	17	the	the	DET
admet-850	105	18	highest	high	ADJ
admet-850	105	19	therapeutic	therapeutic	ADJ
admet-850	105	20	dose	dose	NOUN
admet-850	105	21	(	(	PUNCT
admet-850	105	22	i.e.	i.e.	X
admet-850	105	23	,	,	PUNCT
admet-850	105	24	3,000	3,000	NUM
admet-850	105	25	mg	mg	NOUN
admet-850	105	26	for	for	ADP
admet-850	105	27	amoxicillin	amoxicillin	NOUN
admet-850	105	28	and	and	CCONJ
admet-850	105	29	800	800	NUM
admet-850	105	30	mg	mg	NOUN
admet-850	105	31	for	for	ADP
admet-850	105	32	aciclovir	aciclovir	NOUN
admet-850	105	33	)	)	PUNCT
admet-850	105	34	instead	instead	ADV
admet-850	105	35	of	of	ADP
admet-850	105	36	the	the	DET
admet-850	105	37	highest	high	ADJ
admet-850	105	38	strength	strength	NOUN
admet-850	105	39	as	as	SCONJ
admet-850	105	40	both	both	DET
admet-850	105	41	drugs	drug	NOUN
admet-850	105	42	exhibit	exhibit	VERB
admet-850	105	43	dose	dose	NOUN
admet-850	105	44	-	-	PUNCT
admet-850	105	45	dependent	dependent	ADJ
admet-850	105	46	solubility	solubility	NOUN
admet-850	105	47	profiles	profile	NOUN
admet-850	105	48	[	[	X
admet-850	105	49	13,14	13,14	NUM
admet-850	105	50	]	]	PUNCT
admet-850	105	51	.	.	PUNCT
admet-850	106	1	table	table	NOUN
admet-850	106	2	3	3	NUM
admet-850	106	3	.	.	PUNCT
admet-850	106	4	experimentally	experimentally	ADV
admet-850	106	5	determined	determine	VERB
admet-850	106	6	ph	ph	ADJ
admet-850	106	7	-	-	ADJ
admet-850	106	8	dependent	dependent	ADJ
admet-850	106	9	api	api	NOUN
admet-850	106	10	solubility	solubility	NOUN
admet-850	106	11	using	use	VERB
admet-850	106	12	a	a	DET
admet-850	106	13	globally	globally	ADV
admet-850	106	14	harmonized	harmonized	ADJ
admet-850	106	15	protocol	protocol	NOUN
admet-850	106	16	api	api	NOUN
admet-850	106	17	ph	ph	NOUN
admet-850	106	18	cs	cs	PROPN
admet-850	106	19	mean	mean	VERB
admet-850	106	20	mg	mg	PROPN
admet-850	106	21	/	/	SYM
admet-850	106	22	ml	ml	NOUN
admet-850	106	23	a	a	DET
admet-850	106	24	sd	sd	NOUN
admet-850	106	25	cv%	cv%	PROPN
admet-850	106	26	dsv	dsv	PROPN
admet-850	106	27	solubility	solubility	NOUN
admet-850	106	28	class	class	NOUN
admet-850	106	29	aciclovir	aciclovir	ADP
admet-850	106	30	1.2	1.2	NUM
admet-850	106	31	4.14	4.14	NUM
admet-850	106	32	4.71	4.71	NUM
admet-850	106	33	113.87	113.87	NUM
admet-850	106	34	193.44	193.44	NUM
admet-850	106	35	ls	ls	ADJ
admet-850	106	36	4.5	4.5	NUM
admet-850	106	37	1.25	1.25	NUM
admet-850	106	38	1.11	1.11	NUM
admet-850	106	39	88.96	88.96	NUM
admet-850	106	40	642.57	642.57	NUM
admet-850	106	41	6.8	6.8	NUM
admet-850	106	42	1.27	1.27	NUM
admet-850	106	43	1.10	1.10	NUM
admet-850	106	44	86.45	86.45	NUM
admet-850	106	45	628.93	628.93	NUM
admet-850	106	46	amoxicillin	amoxicillin	NOUN
admet-850	106	47	(	(	PUNCT
admet-850	106	48	trihydrate	trihydrate	NOUN
admet-850	106	49	)	)	PUNCT
admet-850	106	50	1.2	1.2	NUM
admet-850	106	51	9.68	9.68	NUM
admet-850	106	52	13.84	13.84	NUM
admet-850	106	53	142.96	142.96	NUM
admet-850	106	54	206.64	206.64	NUM
admet-850	106	55	ls	ls	PROPN
admet-850	106	56	4.5	4.5	NUM
admet-850	106	57	2.78	2.78	NUM
admet-850	106	58	1.64	1.64	NUM
admet-850	106	59	58.96	58.96	NUM
admet-850	106	60	718.17	718.17	NUM
admet-850	106	61	6.8	6.8	NUM
admet-850	106	62	2.84	2.84	NUM
admet-850	106	63	2.51	2.51	NUM
admet-850	106	64	88.38	88.38	NUM
admet-850	106	65	703.69	703.69	NUM
admet-850	106	66	azithromycin	azithromycin	NOUN
admet-850	106	67	(	(	PUNCT
admet-850	106	68	dihydrate	dihydrate	NOUN
admet-850	106	69	)	)	PUNCT
admet-850	106	70	1.2	1.2	NUM
admet-850	106	71	9.51	9.51	NUM
admet-850	106	72	na	na	NOUN
admet-850	106	73	na	na	ADP
admet-850	106	74	210.39	210.39	NUM
admet-850	106	75	ls	ls	ADJ
admet-850	106	76	4.5	4.5	NUM
admet-850	106	77	6.32	6.32	NUM
admet-850	106	78	4.83	4.83	NUM
admet-850	106	79	76.42	76.42	NUM
admet-850	106	80	316.53	316.53	NUM
admet-850	106	81	6.8	6.8	NUM
admet-850	106	82	6.43	6.43	NUM
admet-850	106	83	0.08	0.08	NUM
admet-850	106	84	1.25	1.25	NUM
admet-850	106	85	310.90	310.90	NUM
admet-850	106	86	cefixime	cefixime	NOUN
admet-850	106	87	(	(	PUNCT
admet-850	106	88	trihydrate	trihydrate	NOUN
admet-850	106	89	)	)	PUNCT
admet-850	106	90	1.2	1.2	NUM
admet-850	106	91	0.72	0.72	NUM
admet-850	106	92	0.76	0.76	NUM
admet-850	106	93	106.07	106.07	NUM
admet-850	106	94	555.56	555.56	NUM
admet-850	106	95	ls	ls	PRON
admet-850	106	96	4.5	4.5	NUM
admet-850	106	97	4.44	4.44	NUM
admet-850	106	98	4.31	4.31	NUM
admet-850	106	99	97.12	97.12	NUM
admet-850	106	100	90.15	90.15	NUM
admet-850	106	101	6.8	6.8	NUM
admet-850	106	102	7.45	7.45	NUM
admet-850	106	103	4.43	4.43	NUM
admet-850	106	104	59.46	59.46	NUM
admet-850	106	105	53.66	53.66	NUM
admet-850	106	106	codeine	codeine	NOUN
admet-850	106	107	(	(	PUNCT
admet-850	106	108	phosphate	phosphate	NOUN
admet-850	106	109	hemihydrate	hemihydrate	NOUN
admet-850	106	110	)	)	PUNCT
admet-850	106	111	1.2	1.2	NUM
admet-850	106	112	60.68	60.68	NUM
admet-850	106	113	42.18	42.18	NUM
admet-850	106	114	69.52	69.52	NUM
admet-850	106	115	0.99	0.99	NUM
admet-850	106	116	hs	hs	PROPN
admet-850	106	117	4.5	4.5	NUM
admet-850	106	118	66.86	66.86	NUM
admet-850	106	119	51.12	51.12	NUM
admet-850	106	120	76.46	76.46	NUM
admet-850	106	121	0.90	0.90	NUM
admet-850	106	122	6.8	6.8	NUM
admet-850	106	123	70.38	70.38	NUM
admet-850	106	124	54.91	54.91	NUM
admet-850	106	125	78.02	78.02	NUM
admet-850	106	126	0.85	0.85	NUM
admet-850	106	127	daclatasvir	daclatasvir	NOUN
admet-850	106	128	(	(	PUNCT
admet-850	106	129	dihydrochloride	dihydrochloride	PROPN
admet-850	106	130	)	)	PUNCT
admet-850	106	131	1.2	1.2	NUM
admet-850	106	132	88.17	88.17	NUM
admet-850	106	133	125.07	125.07	NUM
admet-850	106	134	141.86	141.86	NUM
admet-850	106	135	0.68	0.68	NUM
admet-850	106	136	ls	ls	PROPN
admet-850	106	137	4.5	4.5	NUM
admet-850	106	138	1.78	1.78	NUM
admet-850	106	139	3.48	3.48	NUM
admet-850	106	140	195.74	195.74	NUM
admet-850	106	141	33.72	33.72	NUM
admet-850	106	142	6.8	6.8	NUM
admet-850	106	143	0.10	0.10	NUM
admet-850	106	144	0.14	0.14	NUM
admet-850	106	145	142.09	142.09	NUM
admet-850	106	146	624.09	624.09	NUM
admet-850	106	147	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	ADV
admet-850	106	148	valeria	valeria	PROPN
admet-850	106	149	gigante	gigante	PROPN
admet-850	106	150	et	et	PROPN
admet-850	106	151	al	al	PROPN
admet-850	106	152	.	.	PROPN
admet-850	106	153	admet	admet	PROPN
admet-850	106	154	&	&	CCONJ
admet-850	106	155	dmpk	dmpk	PROPN
admet-850	106	156	9(1	9(1	NUM
admet-850	106	157	)	)	PUNCT
admet-850	106	158	(	(	PUNCT
admet-850	106	159	2021	2021	NUM
admet-850	106	160	)	)	PUNCT
admet-850	106	161	23	23	NUM
admet-850	106	162	-	-	SYM
admet-850	106	163	39	39	NUM
admet-850	106	164	30	30	NUM
admet-850	106	165	table	table	NOUN
admet-850	106	166	3	3	NUM
admet-850	106	167	.	.	NUM
admet-850	106	168	continued	continue	VERB
admet-850	106	169	…	…	PUNCT
admet-850	106	170	api	api	NOUN
admet-850	106	171	ph	ph	NOUN
admet-850	106	172	cs	cs	PROPN
admet-850	106	173	mean	mean	VERB
admet-850	106	174	mg	mg	PROPN
admet-850	106	175	/	/	SYM
admet-850	106	176	ml	ml	NOUN
admet-850	106	177	a	a	DET
admet-850	106	178	sd	sd	NOUN
admet-850	106	179	cv%	cv%	PROPN
admet-850	106	180	dsv	dsv	PROPN
admet-850	106	181	solubility	solubility	NOUN
admet-850	106	182	class	class	NOUN
admet-850	106	183	darunavir	darunavir	PROPN
admet-850	106	184	(	(	PUNCT
admet-850	106	185	ethanolate	ethanolate	VERB
admet-850	106	186	)	)	PUNCT
admet-850	106	187	1.2	1.2	NUM
admet-850	106	188	0.57	0.57	NUM
admet-850	106	189	0.32	0.32	NUM
admet-850	106	190	55.56	55.56	NUM
admet-850	106	191	1402.40	1402.40	NUM
admet-850	106	192	ls	ls	PROPN
admet-850	106	193	4.5	4.5	NUM
admet-850	106	194	0.19	0.19	NUM
admet-850	106	195	0.04	0.04	NUM
admet-850	106	196	23.30	23.30	NUM
admet-850	106	197	4202.05	4202.05	NUM
admet-850	106	198	6.8	6.8	NUM
admet-850	106	199	0.17	0.17	NUM
admet-850	106	200	0.03	0.03	NUM
admet-850	106	201	20.14	20.14	NUM
admet-850	106	202	4776.12	4776.12	NUM
admet-850	106	203	dolutegravir	dolutegravir	NOUN
admet-850	106	204	1.2	1.2	NUM
admet-850	106	205	0.04	0.04	NUM
admet-850	106	206	0.03	0.03	NUM
admet-850	106	207	68.10	68.10	NUM
admet-850	106	208	1252.09	1252.09	NUM
admet-850	106	209	ls	l	VERB
admet-850	106	210	4.5	4.5	NUM
admet-850	106	211	0.04	0.04	NUM
admet-850	106	212	0.02	0.02	NUM
admet-850	106	213	61.99	61.99	NUM
admet-850	106	214	1273.34	1273.34	NUM
admet-850	106	215	6.8	6.8	NUM
admet-850	106	216	0.05	0.05	NUM
admet-850	106	217	0.02	0.02	NUM
admet-850	106	218	44.62	44.62	NUM
admet-850	106	219	943.99	943.99	NUM
admet-850	106	220	efavirenz	efavirenz	NOUN
admet-850	106	221	1.2	1.2	NUM
admet-850	106	222	0.18	0.18	NUM
admet-850	106	223	0.20	0.20	NUM
admet-850	106	224	109.87	109.87	NUM
admet-850	106	225	3331.65	3331.65	NUM
admet-850	106	226	ls	l	VERB
admet-850	106	227	4.5	4.5	NUM
admet-850	106	228	0.20	0.20	NUM
admet-850	106	229	0.24	0.24	NUM
admet-850	106	230	115.60	115.60	NUM
admet-850	106	231	2947.17	2947.17	NUM
admet-850	106	232	6.8	6.8	NUM
admet-850	106	233	0.21	0.21	NUM
admet-850	106	234	0.24	0.24	NUM
admet-850	106	235	114.51	114.51	NUM
admet-850	106	236	2857.39	2857.39	NUM
admet-850	106	237	ethionamide	ethionamide	ADV
admet-850	106	238	1.2	1.2	NUM
admet-850	106	239	10.23	10.23	NUM
admet-850	106	240	12.82	12.82	NUM
admet-850	106	241	125.24	125.24	NUM
admet-850	106	242	24.43	24.43	NUM
admet-850	106	243	ls	ls	PROPN
admet-850	106	244	4.5	4.5	NUM
admet-850	106	245	0.96	0.96	NUM
admet-850	106	246	0.16	0.16	NUM
admet-850	106	247	16.71	16.71	NUM
admet-850	106	248	259.97	259.97	NUM
admet-850	106	249	6.8	6.8	NUM
admet-850	106	250	0.51	0.51	NUM
admet-850	106	251	0.08	0.08	NUM
admet-850	106	252	15.29	15.29	NUM
admet-850	106	253	488.28	488.28	NUM
admet-850	106	254	furosemide	furosemide	ADJ
admet-850	106	255	1.2	1.2	NUM
admet-850	106	256	0.01	0.01	NUM
admet-850	106	257	0.02	0.02	NUM
admet-850	106	258	137.59	137.59	NUM
admet-850	106	259	5818.26	5818.26	NUM
admet-850	106	260	ls	l	VERB
admet-850	106	261	4.5	4.5	NUM
admet-850	106	262	0.14	0.14	NUM
admet-850	106	263	0.05	0.05	NUM
admet-850	106	264	36.66	36.66	NUM
admet-850	106	265	558.95	558.95	NUM
admet-850	106	266	6.8	6.8	NUM
admet-850	106	267	3.74	3.74	NUM
admet-850	106	268	2.04	2.04	NUM
admet-850	106	269	54.39	54.39	NUM
admet-850	106	270	21.37	21.37	NUM
admet-850	106	271	primaquine	primaquine	NOUN
admet-850	106	272	(	(	PUNCT
admet-850	106	273	phosphate	phosphate	NOUN
admet-850	106	274	)	)	PUNCT
admet-850	106	275	1.2	1.2	NUM
admet-850	106	276	50.51	50.51	NUM
admet-850	106	277	62.22	62.22	NUM
admet-850	106	278	123.19	123.19	NUM
admet-850	106	279	0.30	0.30	NUM
admet-850	106	280	hs	hs	PROPN
admet-850	106	281	4.5	4.5	NUM
admet-850	106	282	51.38	51.38	NUM
admet-850	106	283	63.55	63.55	NUM
admet-850	106	284	123.67	123.67	NUM
admet-850	106	285	0.29	0.29	NUM
admet-850	106	286	6.8	6.8	NUM
admet-850	106	287	48.16	48.16	NUM
admet-850	106	288	59.06	59.06	NUM
admet-850	106	289	122.63	122.63	NUM
admet-850	106	290	0.31	0.31	NUM
admet-850	106	291	pyrimethamine	pyrimethamine	NOUN
admet-850	106	292	1.2	1.2	NUM
admet-850	106	293	1.70	1.70	NUM
admet-850	106	294	0.85	0.85	NUM
admet-850	106	295	50.17	50.17	NUM
admet-850	106	296	44.24	44.24	NUM
admet-850	106	297	ls	ls	ADP
admet-850	106	298	4.5	4.5	NUM
admet-850	106	299	4.91	4.91	NUM
admet-850	106	300	3.98	3.98	NUM
admet-850	106	301	80.98	80.98	NUM
admet-850	106	302	15.27	15.27	NUM
admet-850	106	303	6.8	6.8	NUM
admet-850	106	304	0.27	0.27	NUM
admet-850	106	305	0.35	0.35	NUM
admet-850	106	306	128.09	128.09	NUM
admet-850	106	307	277.50	277.50	NUM
admet-850	106	308	raltegravir	raltegravir	NOUN
admet-850	106	309	(	(	PUNCT
admet-850	106	310	potassium	potassium	NOUN
admet-850	106	311	)	)	PUNCT
admet-850	106	312	1.2	1.2	NUM
admet-850	106	313	0.16	0.16	NUM
admet-850	106	314	0.18	0.18	NUM
admet-850	106	315	110.85	110.85	NUM
admet-850	106	316	2513.14	2513.14	NUM
admet-850	106	317	ls	ls	ADP
admet-850	106	318	4.5	4.5	NUM
admet-850	106	319	0.17	0.17	NUM
admet-850	106	320	0.15	0.15	NUM
admet-850	106	321	91.02	91.02	NUM
admet-850	106	322	2363.23	2363.23	NUM
admet-850	106	323	6.8	6.8	NUM
admet-850	106	324	0.48	0.48	NUM
admet-850	106	325	0.56	0.56	NUM
admet-850	106	326	115.85	115.85	NUM
admet-850	106	327	826.45	826.45	NUM
admet-850	106	328	rifampicin	rifampicin	VERB
admet-850	106	329	1.2	1.2	NUM
admet-850	106	330	41.36	41.36	NUM
admet-850	106	331	39.37	39.37	NUM
admet-850	106	332	95.18	95.18	NUM
admet-850	106	333	14.51	14.51	NUM
admet-850	106	334	ls	ls	ADP
admet-850	106	335	4.5	4.5	NUM
admet-850	106	336	0.70	0.70	NUM
admet-850	106	337	0.39	0.39	NUM
admet-850	106	338	55.54	55.54	NUM
admet-850	106	339	851.79	851.79	NUM
admet-850	106	340	6.8	6.8	NUM
admet-850	106	341	1.15	1.15	NUM
admet-850	106	342	0.61	0.61	NUM
admet-850	106	343	52.93	52.93	NUM
admet-850	106	344	521.92	521.92	NUM
admet-850	106	345	tenofovirdisoproxil	tenofovirdisoproxil	NOUN
admet-850	106	346	fumarate	fumarate	NOUN
admet-850	106	347	1.2	1.2	NUM
admet-850	106	348	9.24	9.24	NUM
admet-850	106	349	12.79	12.79	NUM
admet-850	106	350	138.44	138.44	NUM
admet-850	106	351	32.48	32.48	NUM
admet-850	106	352	hs	hs	PROPN
admet-850	106	353	4.5	4.5	NUM
admet-850	106	354	3.94	3.94	NUM
admet-850	106	355	3.46	3.46	NUM
admet-850	106	356	87.78	87.78	NUM
admet-850	106	357	76.14	76.14	NUM
admet-850	106	358	6.8	6.8	NUM
admet-850	106	359	4.35	4.35	NUM
admet-850	106	360	4.53	4.53	NUM
admet-850	106	361	104.12	104.12	NUM
admet-850	106	362	68.97	68.97	NUM
admet-850	106	363	a	a	DET
admet-850	106	364	experimental	experimental	ADJ
admet-850	106	365	data	datum	NOUN
admet-850	106	366	represent	represent	VERB
admet-850	106	367	mean	mean	ADJ
admet-850	106	368	values	value	NOUN
admet-850	106	369	of	of	ADP
admet-850	106	370	three	three	NUM
admet-850	106	371	individual	individual	ADJ
admet-850	106	372	experiments	experiment	NOUN
admet-850	106	373	inter	inter	ADJ
admet-850	106	374	-	-	ADJ
admet-850	106	375	laboratory	laboratory	ADJ
admet-850	106	376	reproducibility	reproducibility	NOUN
admet-850	106	377	to	to	PART
admet-850	106	378	assess	assess	VERB
admet-850	106	379	the	the	DET
admet-850	106	380	robustness	robustness	NOUN
admet-850	106	381	of	of	ADP
admet-850	106	382	the	the	DET
admet-850	106	383	globally	globally	ADV
admet-850	106	384	harmonized	harmonized	ADJ
admet-850	106	385	solubility	solubility	NOUN
admet-850	106	386	protocol	protocol	NOUN
admet-850	106	387	,	,	PUNCT
admet-850	106	388	each	each	DET
admet-850	106	389	api	api	NOUN
admet-850	106	390	was	be	AUX
admet-850	106	391	analyzed	analyze	VERB
admet-850	106	392	by	by	ADP
admet-850	106	393	at	at	ADV
admet-850	106	394	least	least	ADV
admet-850	106	395	three	three	NUM
admet-850	106	396	different	different	ADJ
admet-850	106	397	laboratories	laboratory	NOUN
admet-850	106	398	.	.	PUNCT
admet-850	107	1	the	the	DET
admet-850	107	2	only	only	ADJ
admet-850	107	3	exception	exception	NOUN
admet-850	107	4	was	be	AUX
admet-850	107	5	codeine	codeine	NOUN
admet-850	107	6	,	,	PUNCT
admet-850	107	7	which	which	PRON
admet-850	107	8	was	be	AUX
admet-850	107	9	analyzed	analyze	VERB
admet-850	107	10	by	by	ADP
admet-850	107	11	two	two	NUM
admet-850	107	12	different	different	ADJ
admet-850	107	13	laboratories	laboratory	NOUN
admet-850	107	14	due	due	ADP
admet-850	107	15	to	to	ADP
admet-850	107	16	its	its	PRON
admet-850	107	17	controlled	control	VERB
admet-850	107	18	substance	substance	NOUN
admet-850	107	19	status	status	NOUN
admet-850	107	20	that	that	PRON
admet-850	107	21	limited	limited	ADJ
admet-850	107	22	distribution	distribution	NOUN
admet-850	107	23	across	across	ADP
admet-850	107	24	borders	border	NOUN
admet-850	107	25	.	.	PUNCT
admet-850	108	1	figure	figure	NOUN
admet-850	108	2	1	1	NUM
admet-850	108	3	illustrates	illustrate	VERB
admet-850	108	4	the	the	DET
admet-850	108	5	variability	variability	NOUN
admet-850	108	6	in	in	ADP
admet-850	108	7	ph	ph	ADJ
admet-850	108	8	-	-	ADJ
admet-850	108	9	dependent	dependent	ADJ
admet-850	108	10	solubility	solubility	NOUN
admet-850	108	11	data	datum	NOUN
admet-850	108	12	reported	report	VERB
admet-850	108	13	for	for	ADP
admet-850	108	14	darunavir	darunavir	PROPN
admet-850	108	15	,	,	PUNCT
admet-850	108	16	as	as	ADP
admet-850	108	17	a	a	DET
admet-850	108	18	representative	representative	ADJ
admet-850	108	19	example	example	NOUN
admet-850	108	20	,	,	PUNCT
admet-850	108	21	which	which	PRON
admet-850	108	22	was	be	AUX
admet-850	108	23	analyzed	analyze	VERB
admet-850	108	24	by	by	ADP
admet-850	108	25	six	six	NUM
admet-850	108	26	different	different	ADJ
admet-850	108	27	laboratories	laboratory	NOUN
admet-850	108	28	.	.	PUNCT
admet-850	109	1	laboratory	laboratory	NOUN
admet-850	109	2	-	-	PUNCT
admet-850	109	3	specific	specific	ADJ
admet-850	109	4	interpretation	interpretation	NOUN
admet-850	109	5	of	of	ADP
admet-850	109	6	experimental	experimental	ADJ
admet-850	109	7	parameters	parameter	NOUN
admet-850	109	8	that	that	PRON
admet-850	109	9	were	be	AUX
admet-850	109	10	deliberately	deliberately	ADV
admet-850	109	11	kept	keep	VERB
admet-850	109	12	flexible	flexible	ADJ
admet-850	109	13	in	in	ADP
admet-850	109	14	the	the	DET
admet-850	109	15	globally	globally	ADV
admet-850	109	16	harmonized	harmonize	VERB
admet-850	109	17	protocol	protocol	NOUN
admet-850	109	18	to	to	PART
admet-850	109	19	enable	enable	VERB
admet-850	109	20	wide	wide	ADJ
admet-850	109	21	spread	spread	ADJ
admet-850	109	22	adoption	adoption	NOUN
admet-850	109	23	across	across	ADP
admet-850	109	24	various	various	ADJ
admet-850	109	25	resource	resource	NOUN
admet-850	109	26	settings	setting	NOUN
admet-850	109	27	[	[	X
admet-850	109	28	15	15	NUM
admet-850	109	29	]	]	PUNCT
admet-850	109	30	introduces	introduce	NOUN
admet-850	109	31	unavoidable	unavoidable	ADJ
admet-850	109	32	variability	variability	NOUN
admet-850	109	33	in	in	ADP
admet-850	109	34	absolute	absolute	ADJ
admet-850	109	35	solubility	solubility	NOUN
admet-850	109	36	data	datum	NOUN
admet-850	109	37	,	,	PUNCT
admet-850	109	38	ranging	range	VERB
admet-850	109	39	between	between	ADP
admet-850	109	40	20	20	NUM
admet-850	109	41	-	-	SYM
admet-850	109	42	50	50	NUM
admet-850	109	43	%	%	NOUN
admet-850	109	44	.	.	PUNCT
admet-850	110	1	however	however	ADV
admet-850	110	2	,	,	PUNCT
admet-850	110	3	it	it	PRON
admet-850	110	4	is	be	AUX
admet-850	110	5	important	important	ADJ
admet-850	110	6	to	to	PART
admet-850	110	7	note	note	VERB
admet-850	110	8	that	that	SCONJ
admet-850	110	9	intra	intra	ADJ
admet-850	110	10	-	-	ADJ
admet-850	110	11	laboratory	laboratory	ADJ
admet-850	110	12	variability	variability	NOUN
admet-850	110	13	was	be	AUX
admet-850	110	14	always	always	ADV
admet-850	110	15	≤5	≤5	VERB
admet-850	110	16	%	%	NOUN
admet-850	110	17	and	and	CCONJ
admet-850	110	18	the	the	DET
admet-850	110	19	final	final	ADJ
admet-850	110	20	solubility	solubility	NOUN
admet-850	110	21	classification	classification	NOUN
admet-850	110	22	of	of	ADP
admet-850	110	23	darunavir	darunavir	PROPN
admet-850	110	24	as	as	ADP
admet-850	110	25	a	a	DET
admet-850	110	26	“	"	PUNCT
admet-850	110	27	low	low	ADJ
admet-850	110	28	solubility	solubility	NOUN
admet-850	110	29	”	"	PUNCT
admet-850	110	30	drug	drug	NOUN
admet-850	110	31	was	be	AUX
admet-850	110	32	consistent	consistent	ADJ
admet-850	110	33	among	among	ADP
admet-850	110	34	all	all	DET
admet-850	110	35	laboratories	laboratory	NOUN
admet-850	110	36	.	.	PUNCT
admet-850	111	1	similar	similar	ADJ
admet-850	111	2	consistencies	consistency	NOUN
admet-850	111	3	were	be	AUX
admet-850	111	4	observed	observe	VERB
admet-850	111	5	for	for	ADP
admet-850	111	6	all	all	DET
admet-850	111	7	other	other	ADJ
admet-850	111	8	apis	apis	NOUN
admet-850	111	9	(	(	PUNCT
admet-850	111	10	see	see	VERB
admet-850	111	11	supplemental	supplemental	ADJ
admet-850	111	12	information	information	NOUN
admet-850	111	13	)	)	PUNCT
admet-850	111	14	.	.	PUNCT
admet-850	112	1	admet	admet	PROPN
admet-850	112	2	&	&	CCONJ
admet-850	112	3	dmpk	dmpk	PROPN
admet-850	112	4	9(1	9(1	NUM
admet-850	112	5	)	)	PUNCT
admet-850	112	6	(	(	PUNCT
admet-850	112	7	2021	2021	NUM
admet-850	112	8	)	)	PUNCT
admet-850	112	9	23	23	NUM
admet-850	112	10	-	-	SYM
admet-850	112	11	39	39	NUM
admet-850	112	12	enhancing	enhance	VERB
admet-850	112	13	robustness	robustness	NOUN
admet-850	112	14	of	of	ADP
admet-850	112	15	the	the	PRON
admet-850	112	16	who	who	PRON
admet-850	112	17	biopharmaceutical	biopharmaceutical	ADJ
admet-850	112	18	classification	classification	NOUN
admet-850	112	19	system	system	NOUN
admet-850	112	20	doi	doi	NOUN
admet-850	112	21	:	:	PUNCT
admet-850	112	22	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	X
admet-850	112	23	31	31	NUM
admet-850	112	24	figure	figure	NOUN
admet-850	112	25	1	1	NUM
admet-850	112	26	.	.	PUNCT
admet-850	112	27	experimental	experimental	ADJ
admet-850	112	28	ph	ph	ADJ
admet-850	112	29	-	-	ADJ
admet-850	112	30	dependent	dependent	ADJ
admet-850	112	31	solubility	solubility	NOUN
admet-850	112	32	values	value	NOUN
admet-850	112	33	reported	report	VERB
admet-850	112	34	for	for	ADP
admet-850	112	35	darunavir	darunavir	PROPN
admet-850	112	36	by	by	ADP
admet-850	112	37	six	six	NUM
admet-850	112	38	different	different	ADJ
admet-850	112	39	laboratories	laboratory	NOUN
admet-850	112	40	.	.	PUNCT
admet-850	113	1	dotted	dotted	ADJ
admet-850	113	2	line	line	NOUN
admet-850	113	3	represents	represent	VERB
admet-850	113	4	the	the	DET
admet-850	113	5	class	class	NOUN
admet-850	113	6	boundary	boundary	NOUN
admet-850	113	7	between	between	ADP
admet-850	113	8	“	"	PUNCT
admet-850	113	9	high	high	ADJ
admet-850	113	10	solubility	solubility	NOUN
admet-850	113	11	”	"	PUNCT
admet-850	113	12	and	and	CCONJ
admet-850	113	13	“	"	PUNCT
admet-850	113	14	low	low	ADJ
admet-850	113	15	solubility	solubility	NOUN
admet-850	113	16	”	"	PUNCT
admet-850	113	17	for	for	ADP
admet-850	113	18	the	the	DET
admet-850	113	19	highest	high	ADJ
admet-850	113	20	therapeutic	therapeutic	ADJ
admet-850	113	21	dose	dose	NOUN
admet-850	113	22	of	of	ADP
admet-850	113	23	darunavir	darunavir	PROPN
admet-850	113	24	(	(	PUNCT
admet-850	113	25	i.e.	i.e.	X
admet-850	113	26	,	,	PUNCT
admet-850	113	27	800	800	NUM
admet-850	113	28	mg	mg	NOUN
admet-850	113	29	)	)	PUNCT
admet-850	113	30	avdeef	avdeef	NOUN
admet-850	113	31	and	and	CCONJ
admet-850	113	32	co	co	NOUN
admet-850	113	33	-	-	NOUN
admet-850	113	34	workers	worker	NOUN
admet-850	113	35	examined	examine	VERB
admet-850	113	36	over	over	ADP
admet-850	113	37	800	800	NUM
admet-850	113	38	publications	publication	NOUN
admet-850	113	39	describing	describe	VERB
admet-850	113	40	equilibrium	equilibrium	NOUN
admet-850	113	41	solubility	solubility	NOUN
admet-850	113	42	assessment	assessment	NOUN
admet-850	113	43	of	of	ADP
admet-850	113	44	sparingly	sparingly	ADV
admet-850	113	45	soluble	soluble	ADJ
admet-850	113	46	ionizable	ionizable	ADJ
admet-850	113	47	drug	drug	NOUN
admet-850	113	48	-	-	PUNCT
admet-850	113	49	like	like	ADJ
admet-850	113	50	molecules	molecule	NOUN
admet-850	113	51	by	by	ADP
admet-850	113	52	the	the	DET
admet-850	113	53	shake	shake	NOUN
admet-850	113	54	-	-	PUNCT
admet-850	113	55	flask	flask	NOUN
admet-850	113	56	and	and	CCONJ
admet-850	113	57	related	related	ADJ
admet-850	113	58	methods	method	NOUN
admet-850	113	59	[	[	X
admet-850	113	60	16	16	NUM
admet-850	113	61	]	]	PUNCT
admet-850	113	62	.	.	PUNCT
admet-850	114	1	this	this	DET
admet-850	114	2	comprehensive	comprehensive	ADJ
admet-850	114	3	analysis	analysis	NOUN
admet-850	114	4	identified	identify	VERB
admet-850	114	5	many	many	ADJ
admet-850	114	6	factors	factor	NOUN
admet-850	114	7	that	that	PRON
admet-850	114	8	affect	affect	VERB
admet-850	114	9	the	the	DET
admet-850	114	10	quality	quality	NOUN
admet-850	114	11	of	of	ADP
admet-850	114	12	the	the	DET
admet-850	114	13	experimental	experimental	ADJ
admet-850	114	14	outcome	outcome	NOUN
admet-850	114	15	.	.	PUNCT
admet-850	115	1	among	among	ADP
admet-850	115	2	all	all	DET
admet-850	115	3	studies	study	NOUN
admet-850	115	4	,	,	PUNCT
admet-850	115	5	the	the	DET
admet-850	115	6	reported	report	VERB
admet-850	115	7	standard	standard	ADJ
admet-850	115	8	deviation	deviation	NOUN
admet-850	115	9	among	among	ADP
admet-850	115	10	laboratories	laboratory	NOUN
admet-850	115	11	varied	varied	ADJ
admet-850	115	12	from	from	ADP
admet-850	115	13	0.17	0.17	NUM
admet-850	115	14	to	to	ADP
admet-850	115	15	0.58	0.58	NUM
admet-850	115	16	[	[	X
admet-850	115	17	17	17	NUM
admet-850	115	18	]	]	PUNCT
admet-850	115	19	log	log	NOUN
admet-850	115	20	units	unit	NOUN
admet-850	115	21	with	with	ADP
admet-850	115	22	reported	report	VERB
admet-850	115	23	values	value	NOUN
admet-850	115	24	up	up	ADP
admet-850	115	25	to	to	PART
admet-850	115	26	1.48	1.48	NUM
admet-850	115	27	log	log	NOUN
admet-850	115	28	units	unit	NOUN
admet-850	115	29	for	for	ADP
admet-850	115	30	some	some	DET
admet-850	115	31	sparingly	sparingly	ADV
admet-850	115	32	soluble	soluble	ADJ
admet-850	115	33	compounds	compound	NOUN
admet-850	115	34	.	.	PUNCT
admet-850	116	1	it	it	PRON
admet-850	116	2	is	be	AUX
admet-850	116	3	predicted	predict	VERB
admet-850	116	4	that	that	SCONJ
admet-850	116	5	a	a	DET
admet-850	116	6	standardized	standardized	ADJ
admet-850	116	7	protocol	protocol	NOUN
admet-850	116	8	can	can	AUX
admet-850	116	9	control	control	VERB
admet-850	116	10	some	some	PRON
admet-850	116	11	of	of	ADP
admet-850	116	12	this	this	DET
admet-850	116	13	inter	inter	ADJ
admet-850	116	14	-	-	ADJ
admet-850	116	15	laboratory	laboratory	ADJ
admet-850	116	16	variability	variability	NOUN
admet-850	116	17	.	.	PUNCT
admet-850	117	1	however	however	ADV
admet-850	117	2	,	,	PUNCT
admet-850	117	3	compound	compound	NOUN
admet-850	117	4	-	-	PUNCT
admet-850	117	5	specific	specific	ADJ
admet-850	117	6	factors	factor	NOUN
admet-850	117	7	such	such	ADJ
admet-850	117	8	as	as	ADP
admet-850	117	9	formation	formation	NOUN
admet-850	117	10	of	of	ADP
admet-850	117	11	polymorphs	polymorph	NOUN
admet-850	117	12	,	,	PUNCT
admet-850	117	13	hydrates	hydrate	NOUN
admet-850	117	14	,	,	PUNCT
admet-850	117	15	solvates	solvate	NOUN
admet-850	117	16	,	,	PUNCT
admet-850	117	17	amorphous	amorphous	ADJ
admet-850	117	18	solids	solid	NOUN
admet-850	117	19	,	,	PUNCT
admet-850	117	20	and	and	CCONJ
admet-850	117	21	the	the	DET
admet-850	117	22	impact	impact	NOUN
admet-850	117	23	of	of	ADP
admet-850	117	24	stereoisomers	stereoisomer	NOUN
admet-850	117	25	remain	remain	VERB
admet-850	117	26	sources	source	NOUN
admet-850	117	27	for	for	ADP
admet-850	117	28	experimental	experimental	ADJ
admet-850	117	29	variability	variability	NOUN
admet-850	117	30	despite	despite	SCONJ
admet-850	117	31	the	the	DET
admet-850	117	32	best	good	ADJ
admet-850	117	33	intention	intention	NOUN
admet-850	117	34	for	for	ADP
admet-850	117	35	consistent	consistent	ADJ
admet-850	117	36	experimental	experimental	ADJ
admet-850	117	37	execution	execution	NOUN
admet-850	117	38	of	of	ADP
admet-850	117	39	a	a	DET
admet-850	117	40	protocol	protocol	NOUN
admet-850	117	41	.	.	PUNCT
admet-850	118	1	in	in	ADP
admet-850	118	2	contrast	contrast	NOUN
admet-850	118	3	,	,	PUNCT
admet-850	118	4	the	the	DET
admet-850	118	5	overall	overall	ADJ
admet-850	118	6	standard	standard	ADJ
admet-850	118	7	deviation	deviation	NOUN
admet-850	118	8	among	among	ADP
admet-850	118	9	all	all	PRON
admet-850	118	10	reported	report	VERB
admet-850	118	11	solubility	solubility	NOUN
admet-850	118	12	values	value	NOUN
admet-850	118	13	from	from	ADP
admet-850	118	14	the	the	DET
admet-850	118	15	different	different	ADJ
admet-850	118	16	laboratories	laboratory	NOUN
admet-850	118	17	in	in	ADP
admet-850	118	18	this	this	DET
admet-850	118	19	study	study	NOUN
admet-850	118	20	was	be	AUX
admet-850	118	21	0.83	0.83	NUM
admet-850	118	22	log	log	NOUN
admet-850	118	23	units	unit	NOUN
admet-850	118	24	,	,	PUNCT
admet-850	118	25	but	but	CCONJ
admet-850	118	26	50	50	NUM
admet-850	118	27	%	%	NOUN
admet-850	118	28	of	of	ADP
admet-850	118	29	the	the	DET
admet-850	118	30	api	api	NOUN
admet-850	118	31	data	datum	NOUN
admet-850	118	32	fell	fall	VERB
admet-850	118	33	within	within	ADP
admet-850	118	34	a	a	DET
admet-850	118	35	narrower	narrow	ADJ
admet-850	118	36	range	range	NOUN
admet-850	118	37	of	of	ADP
admet-850	118	38	0.7	0.7	NUM
admet-850	118	39	log	log	NOUN
admet-850	118	40	units	unit	NOUN
admet-850	118	41	,	,	PUNCT
admet-850	118	42	which	which	PRON
admet-850	118	43	is	be	AUX
admet-850	118	44	consistent	consistent	ADJ
admet-850	118	45	with	with	ADP
admet-850	118	46	previous	previous	ADJ
admet-850	118	47	literature	literature	NOUN
admet-850	118	48	comparisons	comparison	NOUN
admet-850	118	49	.	.	PUNCT
admet-850	119	1	figure	figure	NOUN
admet-850	119	2	2	2	NUM
admet-850	119	3	attempts	attempt	NOUN
admet-850	119	4	to	to	PART
admet-850	119	5	visualize	visualize	VERB
admet-850	119	6	this	this	DET
admet-850	119	7	inter	inter	ADJ
admet-850	119	8	-	-	ADJ
admet-850	119	9	laboratory	laboratory	ADJ
admet-850	119	10	variability	variability	NOUN
admet-850	119	11	by	by	ADP
admet-850	119	12	representing	represent	VERB
admet-850	119	13	the	the	DET
admet-850	119	14	distribution	distribution	NOUN
admet-850	119	15	of	of	ADP
admet-850	119	16	solubility	solubility	NOUN
admet-850	119	17	data	datum	NOUN
admet-850	119	18	as	as	ADP
admet-850	119	19	coefficient	coefficient	NOUN
admet-850	119	20	of	of	ADP
admet-850	119	21	variation	variation	NOUN
admet-850	119	22	(	(	PUNCT
admet-850	119	23	cv%	cv%	PROPN
admet-850	119	24	)	)	PUNCT
admet-850	119	25	in	in	ADP
admet-850	119	26	comparison	comparison	NOUN
admet-850	119	27	to	to	ADP
admet-850	119	28	the	the	DET
admet-850	119	29	average	average	ADJ
admet-850	119	30	observe	observe	NOUN
admet-850	119	31	value	value	NOUN
admet-850	119	32	(	(	PUNCT
admet-850	119	33	i.e.	i.e.	X
admet-850	119	34	,	,	PUNCT
admet-850	119	35	100	100	NUM
admet-850	119	36	%	%	NOUN
admet-850	119	37	)	)	PUNCT
admet-850	119	38	.	.	PUNCT
admet-850	120	1	the	the	DET
admet-850	120	2	absence	absence	NOUN
admet-850	120	3	of	of	ADP
admet-850	120	4	a	a	DET
admet-850	120	5	defined	define	VERB
admet-850	120	6	association	association	NOUN
admet-850	120	7	between	between	ADP
admet-850	120	8	inter	inter	ADJ
admet-850	120	9	-	-	ADJ
admet-850	120	10	laboratory	laboratory	ADJ
admet-850	120	11	variability	variability	NOUN
admet-850	120	12	and	and	CCONJ
admet-850	120	13	respective	respective	ADJ
admet-850	120	14	api	api	NOUN
admet-850	120	15	solubility	solubility	NOUN
admet-850	120	16	supports	support	VERB
admet-850	120	17	the	the	DET
admet-850	120	18	robustness	robustness	NOUN
admet-850	120	19	of	of	ADP
admet-850	120	20	the	the	DET
admet-850	120	21	globally	globally	ADV
admet-850	120	22	harmonized	harmonized	ADJ
admet-850	120	23	protocol	protocol	NOUN
admet-850	120	24	.	.	PUNCT
admet-850	121	1	most	most	ADV
admet-850	121	2	importantly	importantly	ADV
admet-850	121	3	,	,	PUNCT
admet-850	121	4	the	the	DET
admet-850	121	5	overall	overall	ADJ
admet-850	121	6	solubility	solubility	NOUN
admet-850	121	7	classification	classification	NOUN
admet-850	121	8	based	base	VERB
admet-850	121	9	on	on	ADP
admet-850	121	10	individual	individual	ADJ
admet-850	121	11	solubility	solubility	NOUN
admet-850	121	12	data	datum	NOUN
admet-850	121	13	was	be	AUX
admet-850	121	14	always	always	ADV
admet-850	121	15	consistent	consistent	ADJ
admet-850	121	16	among	among	ADP
admet-850	121	17	all	all	DET
admet-850	121	18	laboratories	laboratory	NOUN
admet-850	121	19	indicating	indicate	VERB
admet-850	121	20	that	that	SCONJ
admet-850	121	21	key	key	ADJ
admet-850	121	22	determinants	determinant	NOUN
admet-850	121	23	of	of	ADP
admet-850	121	24	the	the	DET
admet-850	121	25	experimental	experimental	ADJ
admet-850	121	26	approach	approach	NOUN
admet-850	121	27	in	in	ADP
admet-850	121	28	this	this	DET
admet-850	121	29	globally	globally	ADV
admet-850	121	30	harmonized	harmonize	VERB
admet-850	121	31	protocol	protocol	NOUN
admet-850	121	32	were	be	AUX
admet-850	121	33	adequately	adequately	ADV
admet-850	121	34	controlled	control	VERB
admet-850	121	35	to	to	PART
admet-850	121	36	allow	allow	VERB
admet-850	121	37	consistent	consistent	ADJ
admet-850	121	38	solubility	solubility	NOUN
admet-850	121	39	assessment	assessment	NOUN
admet-850	121	40	for	for	ADP
admet-850	121	41	the	the	DET
admet-850	121	42	purpose	purpose	NOUN
admet-850	121	43	of	of	ADP
admet-850	121	44	bcs	bcs	NOUN
admet-850	121	45	classification	classification	NOUN
admet-850	121	46	.	.	PUNCT
admet-850	122	1	to	to	PART
admet-850	122	2	explore	explore	VERB
admet-850	122	3	the	the	DET
admet-850	122	4	dependence	dependence	NOUN
admet-850	122	5	of	of	ADP
admet-850	122	6	these	these	DET
admet-850	122	7	solubility	solubility	NOUN
admet-850	122	8	assessments	assessment	NOUN
admet-850	122	9	on	on	ADP
admet-850	122	10	the	the	DET
admet-850	122	11	api	api	NOUN
admet-850	122	12	source	source	NOUN
admet-850	122	13	material	material	NOUN
admet-850	122	14	used	use	VERB
admet-850	122	15	for	for	ADP
admet-850	122	16	the	the	DET
admet-850	122	17	experimental	experimental	ADJ
admet-850	122	18	approach	approach	NOUN
admet-850	122	19	,	,	PUNCT
admet-850	122	20	various	various	ADJ
admet-850	122	21	laboratories	laboratory	NOUN
admet-850	122	22	received	receive	VERB
admet-850	122	23	the	the	DET
admet-850	122	24	same	same	ADJ
admet-850	122	25	api	api	NOUN
admet-850	122	26	that	that	PRON
admet-850	122	27	was	be	AUX
admet-850	122	28	provided	provide	VERB
admet-850	122	29	by	by	ADP
admet-850	122	30	two	two	NUM
admet-850	122	31	or	or	CCONJ
admet-850	122	32	three	three	NUM
admet-850	122	33	different	different	ADJ
admet-850	122	34	suppliers	supplier	NOUN
admet-850	122	35	.	.	PUNCT
admet-850	123	1	figure	figure	VERB
admet-850	123	2	3	3	NUM
admet-850	123	3	summarizes	summarize	NOUN
admet-850	123	4	the	the	DET
admet-850	123	5	results	result	NOUN
admet-850	123	6	for	for	ADP
admet-850	123	7	rifampicin	rifampicin	NOUN
admet-850	123	8	,	,	PUNCT
admet-850	123	9	which	which	PRON
admet-850	123	10	was	be	AUX
admet-850	123	11	obtained	obtain	VERB
admet-850	123	12	from	from	ADP
admet-850	123	13	three	three	NUM
admet-850	123	14	different	different	ADJ
admet-850	123	15	manufacturers	manufacturer	NOUN
admet-850	123	16	and	and	CCONJ
admet-850	123	17	analyzed	analyze	VERB
admet-850	123	18	by	by	ADP
admet-850	123	19	two	two	NUM
admet-850	123	20	different	different	ADJ
admet-850	123	21	laboratories	laboratory	NOUN
admet-850	123	22	.	.	PUNCT
admet-850	124	1	the	the	DET
admet-850	124	2	consistent	consistent	ADJ
admet-850	124	3	solubility	solubility	NOUN
admet-850	124	4	data	datum	NOUN
admet-850	124	5	obtained	obtain	VERB
admet-850	124	6	for	for	ADP
admet-850	124	7	all	all	DET
admet-850	124	8	three	three	NUM
admet-850	124	9	batches	batch	NOUN
admet-850	124	10	suggest	suggest	VERB
admet-850	124	11	that	that	SCONJ
admet-850	124	12	the	the	DET
admet-850	124	13	physical	physical	ADJ
admet-850	124	14	properties	property	NOUN
admet-850	124	15	of	of	ADP
admet-850	124	16	the	the	DET
admet-850	124	17	api	api	NOUN
admet-850	124	18	provided	provide	VERB
admet-850	124	19	by	by	ADP
admet-850	124	20	the	the	DET
admet-850	124	21	different	different	ADJ
admet-850	124	22	suppliers	supplier	NOUN
admet-850	124	23	were	be	AUX
admet-850	124	24	highly	highly	ADV
admet-850	124	25	similar	similar	ADJ
admet-850	124	26	.	.	PUNCT
admet-850	125	1	this	this	DET
admet-850	125	2	conclusion	conclusion	NOUN
admet-850	125	3	is	be	AUX
admet-850	125	4	consistent	consistent	ADJ
admet-850	125	5	with	with	ADP
admet-850	125	6	the	the	DET
admet-850	125	7	requirement	requirement	NOUN
admet-850	125	8	of	of	ADP
admet-850	125	9	this	this	DET
admet-850	125	10	study	study	NOUN
admet-850	125	11	that	that	SCONJ
admet-850	125	12	all	all	DET
admet-850	125	13	apis	api	NOUN
admet-850	125	14	must	must	AUX
admet-850	125	15	comply	comply	VERB
admet-850	125	16	with	with	ADP
admet-850	125	17	compendial	compendial	ADJ
admet-850	125	18	specifications	specification	NOUN
admet-850	125	19	that	that	PRON
admet-850	125	20	include	include	VERB
admet-850	125	21	physical	physical	ADJ
admet-850	125	22	properties	property	NOUN
admet-850	125	23	.	.	PUNCT
admet-850	126	1	it	it	PRON
admet-850	126	2	is	be	AUX
admet-850	126	3	noted	note	VERB
admet-850	126	4	that	that	SCONJ
admet-850	126	5	absolute	absolute	ADJ
admet-850	126	6	solubility	solubility	NOUN
admet-850	126	7	values	value	NOUN
admet-850	126	8	obtained	obtain	VERB
admet-850	126	9	for	for	ADP
admet-850	126	10	the	the	DET
admet-850	126	11	different	different	ADJ
admet-850	126	12	batches	batch	NOUN
admet-850	126	13	of	of	ADP
admet-850	126	14	rifampicin	rifampicin	VERB
admet-850	126	15	at	at	ADP
admet-850	126	16	ph	ph	PROPN
admet-850	126	17	1.2	1.2	NUM
admet-850	126	18	exhibit	exhibit	NOUN
admet-850	126	19	greater	great	ADJ
admet-850	126	20	variability	variability	NOUN
admet-850	126	21	than	than	SCONJ
admet-850	126	22	measured	measure	VERB
admet-850	126	23	at	at	ADP
admet-850	126	24	ph	ph	PROPN
admet-850	126	25	4.5	4.5	NUM
admet-850	126	26	and	and	CCONJ
admet-850	126	27	ph	ph	ADJ
admet-850	126	28	6.8	6.8	NUM
admet-850	126	29	,	,	PUNCT
admet-850	126	30	respectively	respectively	ADV
admet-850	126	31	.	.	PUNCT
admet-850	127	1	the	the	DET
admet-850	127	2	reason	reason	NOUN
admet-850	127	3	for	for	ADP
admet-850	127	4	the	the	DET
admet-850	127	5	higher	high	ADJ
admet-850	127	6	variability	variability	NOUN
admet-850	127	7	observed	observe	VERB
admet-850	127	8	at	at	ADP
admet-850	127	9	ph	ph	PROPN
admet-850	127	10	1.2	1.2	NUM
admet-850	127	11	was	be	AUX
admet-850	127	12	probably	probably	ADV
admet-850	127	13	due	due	ADJ
admet-850	127	14	to	to	ADP
admet-850	127	15	chemical	chemical	ADJ
admet-850	127	16	instability	instability	NOUN
admet-850	127	17	that	that	PRON
admet-850	127	18	was	be	AUX
admet-850	127	19	reported	report	VERB
admet-850	127	20	by	by	ADP
admet-850	127	21	most	most	ADJ
admet-850	127	22	laboratories	laboratory	NOUN
admet-850	127	23	analyzing	analyze	VERB
admet-850	127	24	this	this	DET
admet-850	127	25	api	api	NOUN
admet-850	127	26	.	.	PUNCT
admet-850	127	27	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	PROPN
admet-850	128	1	valeria	valeria	PROPN
admet-850	128	2	gigante	gigante	PROPN
admet-850	128	3	et	et	PROPN
admet-850	128	4	al	al	PROPN
admet-850	128	5	.	.	PROPN
admet-850	128	6	admet	admet	PROPN
admet-850	128	7	&	&	CCONJ
admet-850	128	8	dmpk	dmpk	PROPN
admet-850	128	9	9(1	9(1	NUM
admet-850	128	10	)	)	PUNCT
admet-850	128	11	(	(	PUNCT
admet-850	128	12	2021	2021	NUM
admet-850	128	13	)	)	PUNCT
admet-850	128	14	23	23	NUM
admet-850	128	15	-	-	SYM
admet-850	128	16	39	39	NUM
admet-850	128	17	32	32	NUM
admet-850	128	18	figure	figure	NOUN
admet-850	128	19	2	2	NUM
admet-850	128	20	.	.	PUNCT
admet-850	128	21	observed	observe	VERB
admet-850	128	22	inter	inter	ADJ
admet-850	128	23	-	-	ADJ
admet-850	128	24	laboratory	laboratory	ADJ
admet-850	128	25	variability	variability	NOUN
admet-850	128	26	versus	versus	ADP
admet-850	128	27	average	average	ADJ
admet-850	128	28	solubility	solubility	NOUN
admet-850	128	29	values	value	NOUN
admet-850	128	30	across	across	ADP
admet-850	128	31	experiments	experiment	NOUN
admet-850	128	32	figure	figure	VERB
admet-850	128	33	3	3	NUM
admet-850	128	34	.	.	NOUN
admet-850	128	35	comparative	comparative	ADJ
admet-850	128	36	ph	ph	ADJ
admet-850	128	37	-	-	ADJ
admet-850	128	38	dependent	dependent	ADJ
admet-850	128	39	solubility	solubility	NOUN
admet-850	128	40	profile	profile	NOUN
admet-850	128	41	of	of	ADP
admet-850	128	42	rifampicin	rifampicin	VERB
admet-850	128	43	obtained	obtain	VERB
admet-850	128	44	from	from	ADP
admet-850	128	45	three	three	NUM
admet-850	128	46	different	different	ADJ
admet-850	128	47	suppliers	supplier	NOUN
admet-850	128	48	and	and	CCONJ
admet-850	128	49	analyzed	analyze	VERB
admet-850	128	50	by	by	ADP
admet-850	128	51	two	two	NUM
admet-850	128	52	different	different	ADJ
admet-850	128	53	laboratories	laboratory	NOUN
admet-850	128	54	intestinal	intestinal	ADJ
admet-850	128	55	permeability	permeability	NOUN
admet-850	128	56	harmonization	harmonization	NOUN
admet-850	128	57	across	across	ADP
admet-850	128	58	established	establish	VERB
admet-850	128	59	biowaiver	biowaiver	NOUN
admet-850	128	60	guidance	guidance	NOUN
admet-850	128	61	documents	document	NOUN
admet-850	128	62	consistently	consistently	ADV
admet-850	128	63	defines	define	VERB
admet-850	128	64	the	the	DET
admet-850	128	65	permeability	permeability	NOUN
admet-850	128	66	class	class	NOUN
admet-850	128	67	boundary	boundary	NOUN
admet-850	128	68	for	for	ADP
admet-850	128	69	“	"	PUNCT
admet-850	128	70	high	high	ADJ
admet-850	128	71	permeability	permeability	NOUN
admet-850	128	72	”	"	PUNCT
admet-850	128	73	as	as	SCONJ
admet-850	128	74	the	the	DET
admet-850	128	75	fraction	fraction	NOUN
admet-850	128	76	absorbed	absorb	VERB
admet-850	128	77	(	(	PUNCT
admet-850	128	78	fa	fa	NOUN
admet-850	128	79	)	)	PUNCT
admet-850	128	80	≥85	≥85	NUM
admet-850	128	81	%	%	NOUN
admet-850	128	82	.	.	PUNCT
admet-850	129	1	however	however	ADV
admet-850	129	2	,	,	PUNCT
admet-850	129	3	different	different	ADJ
admet-850	129	4	regulatory	regulatory	ADJ
admet-850	129	5	authorities	authority	NOUN
admet-850	129	6	identify	identify	VERB
admet-850	129	7	either	either	CCONJ
admet-850	129	8	the	the	DET
admet-850	129	9	highest	high	ADJ
admet-850	129	10	therapeutic	therapeutic	ADJ
admet-850	129	11	dose	dose	NOUN
admet-850	129	12	or	or	CCONJ
admet-850	129	13	the	the	DET
admet-850	129	14	highest	high	ADJ
admet-850	129	15	marketed	market	VERB
admet-850	129	16	formulation	formulation	NOUN
admet-850	129	17	strength	strength	NOUN
admet-850	129	18	as	as	ADP
admet-850	129	19	the	the	DET
admet-850	129	20	relevant	relevant	ADJ
admet-850	129	21	dose	dose	NOUN
admet-850	129	22	that	that	PRON
admet-850	129	23	should	should	AUX
admet-850	129	24	be	be	AUX
admet-850	129	25	considered	consider	VERB
admet-850	129	26	for	for	ADP
admet-850	129	27	the	the	DET
admet-850	129	28	purpose	purpose	NOUN
admet-850	129	29	of	of	ADP
admet-850	129	30	a	a	DET
admet-850	129	31	biowaiver	biowaiver	NOUN
admet-850	129	32	pathway	pathway	NOUN
admet-850	130	1	[	[	X
admet-850	130	2	18	18	NUM
admet-850	130	3	]	]	PUNCT
admet-850	130	4	.	.	PUNCT
admet-850	131	1	to	to	PART
admet-850	131	2	explore	explore	VERB
admet-850	131	3	the	the	DET
admet-850	131	4	sensitivity	sensitivity	NOUN
admet-850	131	5	of	of	ADP
admet-850	131	6	the	the	DET
admet-850	131	7	bcs	bcs	NOUN
admet-850	131	8	classification	classification	NOUN
admet-850	131	9	with	with	ADP
admet-850	131	10	respect	respect	NOUN
admet-850	131	11	to	to	ADP
admet-850	131	12	the	the	DET
admet-850	131	13	permeability	permeability	NOUN
admet-850	131	14	of	of	ADP
admet-850	131	15	the	the	DET
admet-850	131	16	oral	oral	ADJ
admet-850	131	17	dose	dose	NOUN
admet-850	131	18	administered	administer	VERB
admet-850	131	19	,	,	PUNCT
admet-850	131	20	computational	computational	ADJ
admet-850	131	21	simulations	simulation	NOUN
admet-850	131	22	using	use	VERB
admet-850	131	23	gastroplus	gastroplus	ADJ
admet-850	131	24	®	®	NOUN
admet-850	131	25	were	be	AUX
admet-850	131	26	performed	perform	VERB
admet-850	131	27	estimating	estimate	VERB
admet-850	131	28	fa	fa	PROPN
admet-850	131	29	for	for	ADP
admet-850	131	30	the	the	DET
admet-850	131	31	highest	high	ADJ
admet-850	131	32	therapeutic	therapeutic	ADJ
admet-850	131	33	dose	dose	NOUN
admet-850	131	34	and	and	CCONJ
admet-850	131	35	highest	high	ADJ
admet-850	131	36	formulation	formulation	NOUN
admet-850	131	37	strength	strength	NOUN
admet-850	131	38	of	of	ADP
admet-850	131	39	each	each	DET
admet-850	131	40	api	api	NOUN
admet-850	131	41	.	.	PUNCT
admet-850	132	1	the	the	DET
admet-850	132	2	results	result	NOUN
admet-850	132	3	from	from	ADP
admet-850	132	4	this	this	PRON
admet-850	132	5	in	in	ADP
admet-850	132	6	silico	silico	NOUN
admet-850	132	7	modeling	model	VERB
admet-850	132	8	approach	approach	NOUN
admet-850	132	9	that	that	PRON
admet-850	132	10	utilized	utilize	VERB
admet-850	132	11	a	a	DET
admet-850	132	12	consistent	consistent	ADJ
admet-850	132	13	set	set	NOUN
admet-850	132	14	of	of	ADP
admet-850	132	15	model	model	NOUN
admet-850	132	16	input	input	NOUN
admet-850	132	17	variables	variable	NOUN
admet-850	132	18	as	as	SCONJ
admet-850	132	19	outlined	outline	VERB
admet-850	132	20	in	in	ADP
admet-850	132	21	table	table	NOUN
admet-850	132	22	2	2	NUM
admet-850	132	23	are	be	AUX
admet-850	132	24	summarized	summarize	VERB
admet-850	132	25	in	in	ADP
admet-850	132	26	figure	figure	NOUN
admet-850	132	27	4	4	NUM
admet-850	132	28	.	.	PUNCT
admet-850	133	1	the	the	DET
admet-850	133	2	almost	almost	ADV
admet-850	133	3	perfect	perfect	ADJ
admet-850	133	4	overlay	overlay	NOUN
admet-850	133	5	between	between	ADP
admet-850	133	6	the	the	DET
admet-850	133	7	two	two	NUM
admet-850	133	8	symbols	symbol	NOUN
admet-850	133	9	representing	represent	VERB
admet-850	133	10	the	the	DET
admet-850	133	11	different	different	ADJ
admet-850	133	12	dose	dose	NOUN
admet-850	133	13	levels	level	NOUN
admet-850	133	14	for	for	ADP
admet-850	133	15	most	most	ADJ
admet-850	133	16	of	of	ADP
admet-850	133	17	the	the	DET
admet-850	133	18	selected	select	VERB
admet-850	133	19	apis	apis	NOUN
admet-850	133	20	in	in	ADP
admet-850	133	21	this	this	DET
admet-850	133	22	training	training	NOUN
admet-850	133	23	set	set	NOUN
admet-850	133	24	suggests	suggest	VERB
admet-850	133	25	that	that	SCONJ
admet-850	133	26	biopharmaceutical	biopharmaceutical	ADJ
admet-850	133	27	properties	property	NOUN
admet-850	133	28	remain	remain	VERB
admet-850	133	29	quite	quite	ADV
admet-850	133	30	constant	constant	ADJ
admet-850	133	31	,	,	PUNCT
admet-850	133	32	irrespectively	irrespectively	ADV
admet-850	133	33	whether	whether	SCONJ
admet-850	133	34	the	the	DET
admet-850	133	35	highest	high	ADJ
admet-850	133	36	therapeutic	therapeutic	ADJ
admet-850	133	37	dose	dose	NOUN
admet-850	133	38	or	or	CCONJ
admet-850	133	39	the	the	DET
admet-850	133	40	highest	high	ADJ
admet-850	133	41	formulation	formulation	NOUN
admet-850	133	42	strength	strength	NOUN
admet-850	133	43	is	be	AUX
admet-850	133	44	modeled	model	VERB
admet-850	133	45	.	.	PUNCT
admet-850	134	1	in	in	ADP
admet-850	134	2	the	the	DET
admet-850	134	3	context	context	NOUN
admet-850	134	4	of	of	ADP
admet-850	134	5	the	the	DET
admet-850	134	6	bcs	bc	NOUN
admet-850	134	7	,	,	PUNCT
admet-850	134	8	this	this	DET
admet-850	134	9	result	result	NOUN
admet-850	134	10	implies	imply	VERB
admet-850	134	11	that	that	SCONJ
admet-850	134	12	admet	admet	PROPN
admet-850	134	13	&	&	CCONJ
admet-850	134	14	dmpk	dmpk	PROPN
admet-850	134	15	9(1	9(1	NUM
admet-850	134	16	)	)	PUNCT
admet-850	134	17	(	(	PUNCT
admet-850	134	18	2021	2021	NUM
admet-850	134	19	)	)	PUNCT
admet-850	134	20	23	23	NUM
admet-850	134	21	-	-	SYM
admet-850	134	22	39	39	NUM
admet-850	134	23	enhancing	enhance	VERB
admet-850	134	24	robustness	robustness	NOUN
admet-850	134	25	of	of	ADP
admet-850	134	26	the	the	PRON
admet-850	134	27	who	who	PRON
admet-850	134	28	biopharmaceutical	biopharmaceutical	ADJ
admet-850	134	29	classification	classification	NOUN
admet-850	134	30	system	system	NOUN
admet-850	134	31	doi	doi	NOUN
admet-850	134	32	:	:	PUNCT
admet-850	134	33	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	134	34	33	33	NUM
admet-850	134	35	gastrointestinal	gastrointestinal	ADJ
admet-850	134	36	solubility	solubility	NOUN
admet-850	134	37	and	and	CCONJ
admet-850	134	38	permeability	permeability	NOUN
admet-850	134	39	remain	remain	VERB
admet-850	134	40	unchanged	unchanged	ADJ
admet-850	134	41	within	within	ADP
admet-850	134	42	the	the	DET
admet-850	134	43	two	two	NUM
admet-850	134	44	different	different	ADJ
admet-850	134	45	dose	dose	NOUN
admet-850	134	46	levels	level	NOUN
admet-850	134	47	compared	compare	VERB
admet-850	134	48	.	.	PUNCT
admet-850	135	1	mechanistically	mechanistically	ADV
admet-850	135	2	,	,	PUNCT
admet-850	135	3	this	this	DET
admet-850	135	4	dose	dose	NOUN
admet-850	135	5	proportionality	proportionality	NOUN
admet-850	135	6	also	also	ADV
admet-850	135	7	supports	support	VERB
admet-850	135	8	the	the	DET
admet-850	135	9	hypothesis	hypothesis	NOUN
admet-850	135	10	that	that	PRON
admet-850	135	11	gastrointestinal	gastrointestinal	ADJ
admet-850	135	12	absorption	absorption	NOUN
admet-850	135	13	for	for	ADP
admet-850	135	14	most	most	ADJ
admet-850	135	15	of	of	ADP
admet-850	135	16	these	these	DET
admet-850	135	17	apis	apis	NOUN
admet-850	135	18	is	be	AUX
admet-850	135	19	predominantly	predominantly	ADV
admet-850	135	20	driven	drive	VERB
admet-850	135	21	by	by	ADP
admet-850	135	22	passive	passive	ADJ
admet-850	135	23	diffusion	diffusion	NOUN
admet-850	135	24	.	.	PUNCT
admet-850	136	1	interestingly	interestingly	ADV
admet-850	136	2	,	,	PUNCT
admet-850	136	3	the	the	DET
admet-850	136	4	visual	visual	ADJ
admet-850	136	5	representation	representation	NOUN
admet-850	136	6	of	of	ADP
admet-850	136	7	these	these	DET
admet-850	136	8	computational	computational	ADJ
admet-850	136	9	simulations	simulation	NOUN
admet-850	136	10	identifies	identify	VERB
admet-850	136	11	two	two	NUM
admet-850	136	12	notable	notable	ADJ
admet-850	136	13	exceptions	exception	NOUN
admet-850	136	14	.	.	PUNCT
admet-850	137	1	the	the	DET
admet-850	137	2	predictions	prediction	NOUN
admet-850	137	3	for	for	ADP
admet-850	137	4	amoxicillin	amoxicillin	NOUN
admet-850	137	5	estimate	estimate	VERB
admet-850	137	6	a	a	DET
admet-850	137	7	fa	fa	NOUN
admet-850	137	8	=	=	SYM
admet-850	137	9	43.9	43.9	NUM
admet-850	137	10	%	%	NOUN
admet-850	137	11	for	for	ADP
admet-850	137	12	the	the	DET
admet-850	137	13	500	500	NUM
admet-850	137	14	mg	mg	PROPN
admet-850	137	15	strength	strength	NOUN
admet-850	137	16	,	,	PUNCT
admet-850	137	17	whereas	whereas	SCONJ
admet-850	137	18	the	the	DET
admet-850	137	19	predicted	predict	VERB
admet-850	137	20	fa	fa	PROPN
admet-850	137	21	for	for	ADP
admet-850	137	22	a	a	DET
admet-850	137	23	therapeutic	therapeutic	ADJ
admet-850	137	24	oral	oral	ADJ
admet-850	137	25	dose	dose	NOUN
admet-850	137	26	of	of	ADP
admet-850	137	27	3,000	3,000	NUM
admet-850	137	28	mg	mg	NOUN
admet-850	137	29	is	be	AUX
admet-850	137	30	only	only	ADV
admet-850	137	31	40.4	40.4	NUM
admet-850	137	32	%	%	NOUN
admet-850	137	33	.	.	PUNCT
admet-850	138	1	although	although	SCONJ
admet-850	138	2	this	this	DET
admet-850	138	3	small	small	ADJ
admet-850	138	4	reduction	reduction	NOUN
admet-850	138	5	in	in	ADP
admet-850	138	6	the	the	DET
admet-850	138	7	predicted	predict	VERB
admet-850	138	8	fa	fa	PROPN
admet-850	138	9	for	for	ADP
admet-850	138	10	3,000	3,000	NUM
admet-850	138	11	mg	mg	PROPN
admet-850	138	12	dose	dose	NOUN
admet-850	138	13	may	may	AUX
admet-850	138	14	need	need	VERB
admet-850	138	15	confirmation	confirmation	NOUN
admet-850	138	16	using	use	VERB
admet-850	138	17	a	a	DET
admet-850	138	18	broader	broad	ADJ
admet-850	138	19	set	set	NOUN
admet-850	138	20	of	of	ADP
admet-850	138	21	simulation	simulation	NOUN
admet-850	138	22	parameters	parameter	NOUN
admet-850	138	23	,	,	PUNCT
admet-850	138	24	it	it	PRON
admet-850	138	25	seems	seem	VERB
admet-850	138	26	consistent	consistent	ADJ
admet-850	138	27	with	with	ADP
admet-850	138	28	results	result	NOUN
admet-850	138	29	from	from	ADP
admet-850	138	30	human	human	ADJ
admet-850	138	31	pharmacokinetic	pharmacokinetic	ADJ
admet-850	138	32	studies	study	NOUN
admet-850	138	33	that	that	PRON
admet-850	138	34	identified	identify	VERB
admet-850	138	35	nonlinear	nonlinear	ADJ
admet-850	138	36	absorption	absorption	NOUN
admet-850	138	37	kinetics	kinetic	NOUN
admet-850	138	38	for	for	ADP
admet-850	138	39	this	this	DET
admet-850	138	40	penicillin	penicillin	NOUN
admet-850	138	41	-	-	PUNCT
admet-850	138	42	type	type	NOUN
admet-850	138	43	antibiotic	antibiotic	NOUN
admet-850	138	44	after	after	ADP
admet-850	138	45	oral	oral	ADJ
admet-850	138	46	administration	administration	NOUN
admet-850	138	47	[	[	X
admet-850	138	48	19	19	NUM
admet-850	138	49	]	]	PUNCT
admet-850	138	50	.	.	PUNCT
admet-850	139	1	mechanistic	mechanistic	ADJ
admet-850	139	2	evaluation	evaluation	NOUN
admet-850	139	3	of	of	ADP
admet-850	139	4	intestinal	intestinal	ADJ
admet-850	139	5	permeation	permeation	NOUN
admet-850	139	6	pathways	pathway	NOUN
admet-850	139	7	contributing	contribute	VERB
admet-850	139	8	to	to	ADP
admet-850	139	9	oral	oral	ADJ
admet-850	139	10	absorption	absorption	NOUN
admet-850	139	11	of	of	ADP
admet-850	139	12	amoxicillin	amoxicillin	PROPN
admet-850	139	13	revealed	reveal	VERB
admet-850	139	14	a	a	DET
admet-850	139	15	saturable	saturable	ADJ
admet-850	139	16	,	,	PUNCT
admet-850	139	17	capacity	capacity	NOUN
admet-850	139	18	-	-	PUNCT
admet-850	139	19	limited	limit	VERB
admet-850	139	20	component	component	NOUN
admet-850	139	21	mediated	mediate	VERB
admet-850	139	22	by	by	ADP
admet-850	139	23	the	the	DET
admet-850	139	24	intestinal	intestinal	ADJ
admet-850	139	25	oligopeptide	oligopeptide	NOUN
admet-850	139	26	transporter	transporter	NOUN
admet-850	139	27	,	,	PUNCT
admet-850	139	28	pept1	pept1	PROPN
admet-850	140	1	[	[	X
admet-850	140	2	20	20	NUM
admet-850	140	3	]	]	PUNCT
admet-850	140	4	.	.	PUNCT
admet-850	141	1	the	the	DET
admet-850	141	2	second	second	ADJ
admet-850	141	3	api	api	NOUN
admet-850	141	4	in	in	ADP
admet-850	141	5	this	this	DET
admet-850	141	6	training	training	NOUN
admet-850	141	7	set	set	NOUN
admet-850	141	8	predicted	predict	VERB
admet-850	141	9	to	to	PART
admet-850	141	10	exhibit	exhibit	VERB
admet-850	141	11	dose	dose	NOUN
admet-850	141	12	-	-	PUNCT
admet-850	141	13	dependent	dependent	ADJ
admet-850	141	14	absorption	absorption	NOUN
admet-850	141	15	kinetics	kinetic	NOUN
admet-850	141	16	is	be	AUX
admet-850	141	17	rifampicin	rifampicin	VERB
admet-850	141	18	.	.	PUNCT
admet-850	142	1	for	for	ADP
admet-850	142	2	the	the	DET
admet-850	142	3	300	300	NUM
admet-850	142	4	mg	mg	PROPN
admet-850	142	5	strength	strength	NOUN
admet-850	142	6	,	,	PUNCT
admet-850	142	7	the	the	DET
admet-850	142	8	estimated	estimate	VERB
admet-850	142	9	fa	fa	X
admet-850	142	10	=	=	SYM
admet-850	142	11	65.6	65.6	NUM
admet-850	142	12	%	%	NOUN
admet-850	142	13	but	but	CCONJ
admet-850	142	14	dramatically	dramatically	ADV
admet-850	142	15	decreases	decrease	VERB
admet-850	142	16	to	to	PART
admet-850	142	17	fa=	fa=	VERB
admet-850	142	18	37.9	37.9	NUM
admet-850	142	19	for	for	ADP
admet-850	142	20	a	a	DET
admet-850	142	21	therapeutic	therapeutic	ADJ
admet-850	142	22	oral	oral	ADJ
admet-850	142	23	dose	dose	NOUN
admet-850	142	24	of	of	ADP
admet-850	142	25	750	750	NUM
admet-850	142	26	mg	mg	NOUN
admet-850	142	27	.	.	PUNCT
admet-850	143	1	mariappan	mariappan	NOUN
admet-850	143	2	and	and	CCONJ
admet-850	143	3	singh	singh	PROPN
admet-850	143	4	assessed	assess	VERB
admet-850	143	5	the	the	DET
admet-850	143	6	mechanisms	mechanism	NOUN
admet-850	143	7	underlying	underlie	VERB
admet-850	143	8	variable	variable	ADJ
admet-850	143	9	gastrointestinal	gastrointestinal	ADJ
admet-850	143	10	absorption	absorption	NOUN
admet-850	143	11	of	of	ADP
admet-850	143	12	rifampicin	rifampicin	NOUN
admet-850	143	13	using	use	VERB
admet-850	143	14	a	a	DET
admet-850	143	15	rat	rat	NOUN
admet-850	143	16	model	model	NOUN
admet-850	143	17	[	[	X
admet-850	143	18	21	21	NUM
admet-850	143	19	]	]	PUNCT
admet-850	143	20	.	.	PUNCT
admet-850	144	1	the	the	DET
admet-850	144	2	results	result	NOUN
admet-850	144	3	from	from	ADP
admet-850	144	4	this	this	DET
admet-850	144	5	preclinical	preclinical	ADJ
admet-850	144	6	study	study	NOUN
admet-850	144	7	provided	provide	VERB
admet-850	144	8	evidence	evidence	NOUN
admet-850	144	9	for	for	ADP
admet-850	144	10	limited	limited	ADJ
admet-850	144	11	transfer	transfer	NOUN
admet-850	144	12	of	of	ADP
admet-850	144	13	this	this	DET
admet-850	144	14	antituberculosis	antituberculosis	NOUN
admet-850	144	15	agent	agent	NOUN
admet-850	144	16	across	across	ADP
admet-850	144	17	the	the	DET
admet-850	144	18	mucosal	mucosal	NOUN
admet-850	144	19	barrier	barrier	NOUN
admet-850	144	20	in	in	ADP
admet-850	144	21	a	a	DET
admet-850	144	22	regio	regio	NOUN
admet-850	144	23	-	-	PUNCT
admet-850	144	24	specific	specific	ADJ
admet-850	144	25	manner	manner	NOUN
admet-850	144	26	(	(	PUNCT
admet-850	144	27	jejunum	jejunum	NOUN
admet-850	144	28	>	>	X
admet-850	144	29	ileum	ileum	NOUN
admet-850	144	30	)	)	PUNCT
admet-850	144	31	due	due	ADP
admet-850	144	32	to	to	ADP
admet-850	144	33	significant	significant	ADJ
admet-850	144	34	affinity	affinity	NOUN
admet-850	144	35	for	for	ADP
admet-850	144	36	intestinal	intestinal	ADJ
admet-850	144	37	efflux	efflux	NOUN
admet-850	144	38	systems	system	NOUN
admet-850	144	39	such	such	ADJ
admet-850	144	40	as	as	ADP
admet-850	144	41	p	p	NOUN
admet-850	144	42	-	-	PUNCT
admet-850	144	43	glycoprotein	glycoprotein	NOUN
admet-850	144	44	.	.	PUNCT
admet-850	145	1	moreover	moreover	ADV
admet-850	145	2	,	,	PUNCT
admet-850	145	3	it	it	PRON
admet-850	145	4	was	be	AUX
admet-850	145	5	discovered	discover	VERB
admet-850	145	6	that	that	SCONJ
admet-850	145	7	transepithelial	transepithelial	ADJ
admet-850	145	8	flux	flux	NOUN
admet-850	145	9	of	of	ADP
admet-850	145	10	rifampicin	rifampicin	VERB
admet-850	145	11	in	in	ADP
admet-850	145	12	the	the	DET
admet-850	145	13	duodenum	duodenum	NOUN
admet-850	145	14	increased	increase	VERB
admet-850	145	15	up	up	ADP
admet-850	145	16	to	to	PART
admet-850	145	17	limit	limit	VERB
admet-850	145	18	of	of	ADP
admet-850	145	19	300	300	NUM
admet-850	145	20	µg	µg	NOUN
admet-850	145	21	/	/	SYM
admet-850	145	22	ml	ml	NOUN
admet-850	145	23	and	and	CCONJ
admet-850	145	24	becoming	become	VERB
admet-850	145	25	constant	constant	ADJ
admet-850	145	26	thereafter	thereafter	ADV
admet-850	145	27	,	,	PUNCT
admet-850	145	28	which	which	PRON
admet-850	145	29	is	be	AUX
admet-850	145	30	indicative	indicative	ADJ
admet-850	145	31	of	of	ADP
admet-850	145	32	a	a	DET
admet-850	145	33	saturable	saturable	ADJ
admet-850	145	34	absorption	absorption	NOUN
admet-850	145	35	component	component	NOUN
admet-850	145	36	such	such	ADJ
admet-850	145	37	as	as	ADP
admet-850	145	38	an	an	DET
admet-850	145	39	influx	influx	NOUN
admet-850	145	40	transporter	transporter	NOUN
admet-850	145	41	.	.	PUNCT
admet-850	146	1	since	since	SCONJ
admet-850	146	2	the	the	DET
admet-850	146	3	predicted	predict	VERB
admet-850	146	4	fa	fa	PROPN
admet-850	146	5	for	for	ADP
admet-850	146	6	either	either	CCONJ
admet-850	146	7	the	the	DET
admet-850	146	8	highest	high	ADJ
admet-850	146	9	therapeutic	therapeutic	ADJ
admet-850	146	10	dose	dose	NOUN
admet-850	146	11	or	or	CCONJ
admet-850	146	12	highest	high	ADJ
admet-850	146	13	formulation	formulation	NOUN
admet-850	146	14	strength	strength	NOUN
admet-850	146	15	of	of	ADP
admet-850	146	16	amoxicillin	amoxicillin	NOUN
admet-850	146	17	and	and	CCONJ
admet-850	146	18	rifampicin	rifampicin	VERB
admet-850	146	19	were	be	AUX
admet-850	146	20	<	<	X
admet-850	146	21	85	85	NUM
admet-850	146	22	%	%	NOUN
admet-850	146	23	,	,	PUNCT
admet-850	146	24	both	both	CCONJ
admet-850	146	25	apis	apis	ADJ
admet-850	146	26	were	be	AUX
admet-850	146	27	qualified	qualified	ADJ
admet-850	146	28	as	as	ADP
admet-850	146	29	“	"	PUNCT
admet-850	146	30	low	low	ADJ
admet-850	146	31	permeability	permeability	NOUN
admet-850	146	32	”	"	PUNCT
admet-850	146	33	drugs	drug	NOUN
admet-850	146	34	when	when	SCONJ
admet-850	146	35	using	use	VERB
admet-850	146	36	the	the	DET
admet-850	146	37	computationally	computationally	ADV
admet-850	146	38	predicted	predict	VERB
admet-850	146	39	permeability	permeability	NOUN
admet-850	146	40	parameter	parameter	NOUN
admet-850	146	41	for	for	ADP
admet-850	146	42	the	the	DET
admet-850	146	43	purpose	purpose	NOUN
admet-850	146	44	of	of	ADP
admet-850	146	45	bcs	bcs	NOUN
admet-850	146	46	classification	classification	NOUN
admet-850	146	47	.	.	PUNCT
admet-850	147	1	figure	figure	NOUN
admet-850	147	2	4	4	NUM
admet-850	147	3	.	.	PUNCT
admet-850	148	1	intestinal	intestinal	ADJ
admet-850	148	2	permeability	permeability	NOUN
admet-850	148	3	classification	classification	NOUN
admet-850	148	4	.	.	PUNCT
admet-850	149	1	fraction	fraction	NOUN
admet-850	149	2	absorbed	absorb	VERB
admet-850	149	3	in	in	ADP
admet-850	149	4	humans	human	NOUN
admet-850	149	5	after	after	SCONJ
admet-850	149	6	oral	oral	ADJ
admet-850	149	7	administration	administration	NOUN
admet-850	149	8	of	of	ADP
admet-850	149	9	an	an	DET
admet-850	149	10	immediate	immediate	ADJ
admet-850	149	11	-	-	PUNCT
admet-850	149	12	release	release	NOUN
admet-850	149	13	tablet	tablet	NOUN
admet-850	149	14	was	be	AUX
admet-850	149	15	predicted	predict	VERB
admet-850	149	16	for	for	ADP
admet-850	149	17	the	the	DET
admet-850	149	18	highest	high	ADJ
admet-850	149	19	daily	daily	ADJ
admet-850	149	20	dose	dose	NOUN
admet-850	149	21	(	(	PUNCT
admet-850	149	22	red	red	ADJ
admet-850	149	23	squares	square	NOUN
admet-850	149	24	)	)	PUNCT
admet-850	149	25	and	and	CCONJ
admet-850	149	26	the	the	DET
admet-850	149	27	highest	high	ADJ
admet-850	149	28	formulation	formulation	NOUN
admet-850	149	29	strength	strength	NOUN
admet-850	149	30	(	(	PUNCT
admet-850	149	31	green	green	ADJ
admet-850	149	32	circles	circle	NOUN
admet-850	149	33	)	)	PUNCT
admet-850	149	34	using	use	VERB
admet-850	149	35	gastroplus	gastroplus	ADJ
admet-850	149	36	®	®	NOUN
admet-850	149	37	.	.	PUNCT
admet-850	150	1	these	these	DET
admet-850	150	2	simulated	simulate	VERB
admet-850	150	3	predictions	prediction	NOUN
admet-850	150	4	were	be	AUX
admet-850	150	5	compared	compare	VERB
admet-850	150	6	with	with	ADP
admet-850	150	7	results	result	NOUN
admet-850	150	8	from	from	ADP
admet-850	150	9	clinical	clinical	ADJ
admet-850	150	10	oral	oral	ADJ
admet-850	150	11	bioavailability	bioavailability	NOUN
admet-850	150	12	studies	study	NOUN
admet-850	150	13	performed	perform	VERB
admet-850	150	14	in	in	ADP
admet-850	150	15	humans	human	NOUN
admet-850	150	16	(	(	PUNCT
admet-850	150	17	see	see	VERB
admet-850	150	18	table	table	NOUN
admet-850	150	19	3	3	NUM
admet-850	150	20	for	for	ADP
admet-850	150	21	references	reference	NOUN
admet-850	150	22	)	)	PUNCT
admet-850	150	23	.	.	PUNCT
admet-850	151	1	the	the	DET
admet-850	151	2	“	"	PUNCT
admet-850	151	3	high	high	ADJ
admet-850	151	4	permeability	permeability	NOUN
admet-850	151	5	”	"	PUNCT
admet-850	151	6	class	class	NOUN
admet-850	151	7	boundary	boundary	NOUN
admet-850	151	8	at	at	ADP
admet-850	151	9	the	the	DET
admet-850	151	10	fraction	fraction	NOUN
admet-850	151	11	absorbed	absorb	VERB
admet-850	151	12	(	(	PUNCT
admet-850	151	13	fa	fa	NOUN
admet-850	151	14	)	)	PUNCT
admet-850	151	15	=	=	SYM
admet-850	151	16	85	85	NUM
admet-850	151	17	%	%	NOUN
admet-850	151	18	is	be	AUX
admet-850	151	19	represents	represent	NOUN
admet-850	151	20	by	by	ADP
admet-850	151	21	the	the	DET
admet-850	151	22	dashed	dash	VERB
admet-850	151	23	line	line	NOUN
admet-850	151	24	the	the	DET
admet-850	151	25	results	result	NOUN
admet-850	151	26	from	from	ADP
admet-850	151	27	these	these	DET
admet-850	151	28	exploratory	exploratory	NOUN
admet-850	151	29	in	in	ADP
admet-850	151	30	silico	silico	NOUN
admet-850	151	31	permeability	permeability	NOUN
admet-850	151	32	predictions	prediction	NOUN
admet-850	151	33	using	use	VERB
admet-850	151	34	default	default	NOUN
admet-850	151	35	simulation	simulation	NOUN
admet-850	151	36	algorithms	algorithm	NOUN
admet-850	151	37	of	of	ADP
admet-850	151	38	gastroplus	gastroplus	ADJ
admet-850	151	39	©	©	PROPN
admet-850	151	40	identified	identify	VERB
admet-850	151	41	seven	seven	NUM
admet-850	151	42	apis	apis	ADV
admet-850	151	43	from	from	ADP
admet-850	151	44	this	this	DET
admet-850	151	45	training	training	NOUN
admet-850	151	46	set	set	NOUN
admet-850	151	47	,	,	PUNCT
admet-850	151	48	namely	namely	ADV
admet-850	151	49	codeine	codeine	NOUN
admet-850	151	50	,	,	PUNCT
admet-850	151	51	daclatasvir	daclatasvir	PROPN
admet-850	151	52	,	,	PUNCT
admet-850	151	53	dolutegravir	dolutegravir	PROPN
admet-850	151	54	,	,	PUNCT
admet-850	151	55	ethionamide	ethionamide	NOUN
admet-850	151	56	,	,	PUNCT
admet-850	151	57	primaquine	primaquine	NOUN
admet-850	151	58	,	,	PUNCT
admet-850	151	59	pyrimethamine	pyrimethamine	NOUN
admet-850	151	60	,	,	PUNCT
admet-850	151	61	and	and	CCONJ
admet-850	151	62	raltegravir	raltegravir	PROPN
admet-850	151	63	as	as	ADP
admet-850	151	64	“	"	PUNCT
admet-850	151	65	high	high	ADJ
admet-850	151	66	permeability	permeability	NOUN
admet-850	151	67	”	"	PUNCT
admet-850	151	68	drugs	drug	NOUN
admet-850	151	69	according	accord	VERB
admet-850	151	70	to	to	ADP
admet-850	151	71	the	the	DET
admet-850	151	72	0	0	NUM
admet-850	151	73	2	2	NUM
admet-850	151	74	0	0	NUM
admet-850	151	75	4	4	NUM
admet-850	151	76	0	0	NUM
admet-850	151	77	6	6	NUM
admet-850	151	78	0	0	NUM
admet-850	151	79	8	8	NUM
admet-850	151	80	0	0	NUM
admet-850	151	81	1	1	NUM
admet-850	151	82	0	0	NUM
admet-850	151	83	0	0	NUM
admet-850	151	84	1	1	NUM
admet-850	151	85	2	2	NUM
admet-850	151	86	0	0	NUM
admet-850	151	87	0	0	NUM
admet-850	151	88	2	2	NUM
admet-850	151	89	0	0	NUM
admet-850	151	90	4	4	NUM
admet-850	151	91	0	0	NUM
admet-850	151	92	6	6	NUM
admet-850	151	93	0	0	NUM
admet-850	151	94	8	8	NUM
admet-850	151	95	0	0	NUM
admet-850	151	96	1	1	NUM
admet-850	151	97	0	0	NUM
admet-850	151	98	0	0	NUM
admet-850	151	99	1	1	NUM
admet-850	151	100	2	2	NUM
admet-850	151	101	0	0	NUM
admet-850	151	102	o	o	NOUN
admet-850	151	103	r	r	NOUN
admet-850	151	104	a	a	DET
admet-850	151	105	l	l	NOUN
admet-850	151	106	b	b	NOUN
admet-850	152	1	i	i	PRON
admet-850	152	2	o	o	VERB
admet-850	152	3	a	a	DET
admet-850	152	4	v	v	NOUN
admet-850	152	5	a	a	PRON
admet-850	153	1	i	i	NOUN
admet-850	153	2	l	l	NOUN
admet-850	154	1	a	a	PRON
admet-850	154	2	b	b	NOUN
admet-850	155	1	i	i	NOUN
admet-850	155	2	l	l	NOUN
admet-850	156	1	i	i	PRON
admet-850	156	2	t	t	VERB
admet-850	156	3	y	y	PROPN
admet-850	157	1	i	i	PRON
admet-850	157	2	n	n	VERB
admet-850	157	3	h	h	NOUN
admet-850	157	4	u	u	NOUN
admet-850	157	5	m	m	VERB
admet-850	157	6	a	a	PRON
admet-850	157	7	n	n	NOUN
admet-850	157	8	s	s	NOUN
admet-850	157	9	m	m	VERB
admet-850	157	10	e	e	NOUN
admet-850	157	11	a	a	PRON
admet-850	157	12	s	s	X
admet-850	157	13	u	u	NOUN
admet-850	157	14	r	r	NOUN
admet-850	157	15	e	e	NOUN
admet-850	157	16	d	d	NOUN
admet-850	157	17	[	[	PUNCT
admet-850	157	18	%	%	X
admet-850	157	19	]	]	X
admet-850	157	20	f	f	X
admet-850	157	21	r	r	NOUN
admet-850	157	22	a	a	PROPN
admet-850	157	23	c	c	NOUN
admet-850	157	24	t	t	X
admet-850	157	25	io	io	PROPN
admet-850	157	26	n	n	PROPN
admet-850	157	27	a	a	PRON
admet-850	157	28	b	b	NOUN
admet-850	157	29	s	s	NOUN
admet-850	157	30	o	o	NOUN
admet-850	157	31	r	r	NOUN
admet-850	157	32	b	b	PROPN
admet-850	157	33	e	e	X
admet-850	158	1	d	d	NOUN
admet-850	158	2	i	i	PRON
admet-850	158	3	n	n	VERB
admet-850	158	4	h	h	NOUN
admet-850	158	5	u	u	NOUN
admet-850	158	6	m	m	VERB
admet-850	158	7	a	a	PRON
admet-850	158	8	n	n	NOUN
admet-850	158	9	s	s	NOUN
admet-850	158	10	p	p	NOUN
admet-850	158	11	r	r	NOUN
admet-850	158	12	e	e	NOUN
admet-850	158	13	d	d	X
admet-850	158	14	ic	ic	PROPN
admet-850	158	15	t	t	X
admet-850	158	16	e	e	X
admet-850	158	17	d	d	X
admet-850	158	18	[	[	PUNCT
admet-850	158	19	%	%	X
admet-850	158	20	]	]	X
admet-850	158	21	oral	oral	ADJ
admet-850	158	22	bioavailability	bioavailability	NOUN
admet-850	158	23	in	in	ADP
admet-850	158	24	humans	human	NOUN
admet-850	158	25	measured	measure	VERB
admet-850	158	26	,	,	PUNCT
admet-850	158	27	%	%	INTJ
admet-850	159	1	fr	fr	INTJ
admet-850	159	2	ac	ac	INTJ
admet-850	159	3	ti	ti	PROPN
admet-850	159	4	o	o	PROPN
admet-850	160	1	n	n	ADP
admet-850	160	2	a	a	DET
admet-850	160	3	b	b	NOUN
admet-850	160	4	so	so	SCONJ
admet-850	160	5	rb	rb	NOUN
admet-850	161	1	ed	ed	NOUN
admet-850	161	2	in	in	ADP
admet-850	161	3	h	h	PROPN
admet-850	161	4	u	u	NOUN
admet-850	161	5	m	m	VERB
admet-850	161	6	an	an	PRON
admet-850	161	7	s	s	X
admet-850	161	8	p	p	X
admet-850	161	9	re	re	ADP
admet-850	161	10	d	d	NOUN
admet-850	161	11	ic	ic	X
admet-850	162	1	te	te	PROPN
admet-850	162	2	d	d	PROPN
admet-850	162	3	,	,	PUNCT
admet-850	162	4	%	%	INTJ
admet-850	162	5	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	PROPN
admet-850	162	6	valeria	valeria	PROPN
admet-850	162	7	gigante	gigante	PROPN
admet-850	162	8	et	et	PROPN
admet-850	162	9	al	al	PROPN
admet-850	162	10	.	.	PROPN
admet-850	162	11	admet	admet	PROPN
admet-850	162	12	&	&	CCONJ
admet-850	162	13	dmpk	dmpk	PROPN
admet-850	162	14	9(1	9(1	NUM
admet-850	162	15	)	)	PUNCT
admet-850	162	16	(	(	PUNCT
admet-850	162	17	2021	2021	NUM
admet-850	162	18	)	)	PUNCT
admet-850	162	19	23	23	NUM
admet-850	162	20	-	-	SYM
admet-850	162	21	39	39	NUM
admet-850	162	22	34	34	NUM
admet-850	162	23	who	who	PRON
admet-850	162	24	bcs	bc	VERB
admet-850	162	25	threshold	threshold	NOUN
admet-850	162	26	of	of	ADP
admet-850	162	27	fa	fa	PROPN
admet-850	162	28	≥85	≥85	NOUN
admet-850	162	29	%	%	NOUN
admet-850	162	30	.	.	PUNCT
admet-850	163	1	in	in	ADP
admet-850	163	2	comparison	comparison	NOUN
admet-850	163	3	to	to	ADP
admet-850	163	4	clinically	clinically	ADV
admet-850	163	5	determined	determine	VERB
admet-850	163	6	human	human	ADJ
admet-850	163	7	bioavailability	bioavailability	NOUN
admet-850	163	8	(	(	PUNCT
admet-850	163	9	f	f	X
admet-850	163	10	)	)	PUNCT
admet-850	163	11	data	datum	NOUN
admet-850	163	12	for	for	ADP
admet-850	163	13	these	these	DET
admet-850	163	14	“	"	PUNCT
admet-850	163	15	high	high	ADJ
admet-850	163	16	permeability	permeability	NOUN
admet-850	163	17	”	"	PUNCT
admet-850	163	18	drugs	drug	NOUN
admet-850	163	19	identified	identify	VERB
admet-850	163	20	from	from	ADP
admet-850	163	21	the	the	DET
admet-850	163	22	primary	primary	ADJ
admet-850	163	23	literature	literature	NOUN
admet-850	163	24	,	,	PUNCT
admet-850	163	25	the	the	DET
admet-850	163	26	variability	variability	NOUN
admet-850	163	27	in	in	ADP
admet-850	163	28	the	the	DET
admet-850	163	29	fractions	fraction	NOUN
admet-850	163	30	of	of	ADP
admet-850	163	31	the	the	DET
admet-850	163	32	drug	drug	NOUN
admet-850	163	33	reaching	reach	VERB
admet-850	163	34	the	the	DET
admet-850	163	35	systemic	systemic	ADJ
admet-850	163	36	circulation	circulation	NOUN
admet-850	163	37	in	in	ADP
admet-850	163	38	vivo	vivo	NOUN
admet-850	163	39	(	(	PUNCT
admet-850	163	40	30.0	30.0	NUM
admet-850	163	41	%	%	NOUN
admet-850	163	42	≤	≤	X
admet-850	163	43	f	f	PROPN
admet-850	163	44	≤	≤	NUM
admet-850	163	45	96.0	96.0	NUM
admet-850	163	46	%	%	NOUN
admet-850	163	47	)	)	PUNCT
admet-850	163	48	is	be	AUX
admet-850	163	49	significantly	significantly	ADV
admet-850	163	50	greater	great	ADJ
admet-850	163	51	than	than	ADP
admet-850	163	52	the	the	DET
admet-850	163	53	computationally	computationally	ADV
admet-850	163	54	predicted	predict	VERB
admet-850	163	55	fraction	fraction	NOUN
admet-850	163	56	absorbed	absorb	VERB
admet-850	163	57	using	use	VERB
admet-850	163	58	gastroplus	gastroplus	ADJ
admet-850	163	59	©	©	PROPN
admet-850	163	60	(	(	PUNCT
admet-850	163	61	95.8	95.8	NUM
admet-850	163	62	%	%	NOUN
admet-850	163	63	≤	≤	NUM
admet-850	163	64	fa	fa	NOUN
admet-850	163	65	≤	≤	NUM
admet-850	163	66	99.8	99.8	NUM
admet-850	163	67	%	%	NOUN
admet-850	163	68	)	)	PUNCT
admet-850	163	69	.	.	PUNCT
admet-850	164	1	this	this	PRON
admet-850	164	2	is	be	AUX
admet-850	164	3	an	an	DET
admet-850	164	4	important	important	ADJ
admet-850	164	5	reminder	reminder	NOUN
admet-850	164	6	of	of	ADP
admet-850	164	7	the	the	DET
admet-850	164	8	critical	critical	ADJ
admet-850	164	9	role	role	NOUN
admet-850	164	10	of	of	ADP
admet-850	164	11	model	model	NOUN
admet-850	164	12	input	input	NOUN
admet-850	164	13	data	datum	NOUN
admet-850	164	14	that	that	PRON
admet-850	164	15	are	be	AUX
admet-850	164	16	used	use	VERB
admet-850	164	17	to	to	PART
admet-850	164	18	perform	perform	VERB
admet-850	164	19	pbpk	pbpk	ADJ
admet-850	164	20	simulations	simulation	NOUN
admet-850	164	21	.	.	PUNCT
admet-850	165	1	gastroplus	gastroplus	PROPN
admet-850	165	2	©	©	PROPN
admet-850	165	3	was	be	AUX
admet-850	165	4	used	use	VERB
admet-850	165	5	in	in	ADP
admet-850	165	6	this	this	DET
admet-850	165	7	study	study	NOUN
admet-850	165	8	as	as	ADP
admet-850	165	9	an	an	DET
admet-850	165	10	example	example	NOUN
admet-850	165	11	to	to	PART
admet-850	165	12	illustrate	illustrate	VERB
admet-850	165	13	the	the	DET
admet-850	165	14	potential	potential	NOUN
admet-850	165	15	of	of	ADP
admet-850	165	16	a	a	DET
admet-850	165	17	bottom	bottom	NOUN
admet-850	165	18	-	-	PUNCT
admet-850	165	19	up	up	ADP
admet-850	165	20	pbpk	pbpk	PROPN
admet-850	165	21	simulation	simulation	NOUN
admet-850	165	22	tool	tool	NOUN
admet-850	165	23	when	when	SCONJ
admet-850	165	24	exploring	explore	VERB
admet-850	165	25	bcs	bcs	NOUN
admet-850	165	26	classification	classification	NOUN
admet-850	165	27	of	of	ADP
admet-850	165	28	apis	apis	PROPN
admet-850	165	29	for	for	ADP
admet-850	165	30	which	which	PRON
admet-850	165	31	no	no	DET
admet-850	165	32	clinical	clinical	ADJ
admet-850	165	33	bioavailability	bioavailability	NOUN
admet-850	165	34	data	datum	NOUN
admet-850	165	35	are	be	AUX
admet-850	165	36	available	available	ADJ
admet-850	165	37	.	.	PUNCT
admet-850	166	1	nevertheless	nevertheless	ADV
admet-850	166	2	,	,	PUNCT
admet-850	166	3	default	default	NOUN
admet-850	166	4	simulation	simulation	NOUN
admet-850	166	5	parameters	parameter	NOUN
admet-850	166	6	as	as	SCONJ
admet-850	166	7	outlined	outline	VERB
admet-850	166	8	in	in	ADP
admet-850	166	9	table	table	NOUN
admet-850	166	10	2	2	NUM
admet-850	166	11	may	may	AUX
admet-850	166	12	not	not	PART
admet-850	166	13	adequately	adequately	ADV
admet-850	166	14	represent	represent	VERB
admet-850	166	15	the	the	DET
admet-850	166	16	specific	specific	ADJ
admet-850	166	17	conditions	condition	NOUN
admet-850	166	18	encountered	encounter	VERB
admet-850	166	19	in	in	ADP
admet-850	166	20	vivo	vivo	NOUN
admet-850	166	21	.	.	PUNCT
admet-850	167	1	this	this	PRON
admet-850	167	2	may	may	AUX
admet-850	167	3	include	include	VERB
admet-850	167	4	important	important	ADJ
admet-850	167	5	volumetric	volumetric	ADJ
admet-850	167	6	terms	term	NOUN
admet-850	167	7	of	of	ADP
admet-850	167	8	gastrointestinal	gastrointestinal	ADJ
admet-850	167	9	segments	segment	NOUN
admet-850	167	10	that	that	PRON
admet-850	167	11	can	can	AUX
admet-850	167	12	affect	affect	VERB
admet-850	167	13	drug	drug	NOUN
admet-850	167	14	solubility	solubility	NOUN
admet-850	167	15	and/or	and/or	CCONJ
admet-850	167	16	precipitation	precipitation	NOUN
admet-850	167	17	rate	rate	NOUN
admet-850	167	18	of	of	ADP
admet-850	167	19	a	a	DET
admet-850	167	20	free	free	ADJ
admet-850	167	21	salt	salt	NOUN
admet-850	167	22	form	form	NOUN
admet-850	167	23	and	and	CCONJ
admet-850	167	24	a	a	DET
admet-850	167	25	solvate	solvate	NOUN
admet-850	167	26	.	.	PUNCT
admet-850	168	1	alternatively	alternatively	ADV
admet-850	168	2	,	,	PUNCT
admet-850	168	3	physiological	physiological	ADJ
admet-850	168	4	contribution	contribution	NOUN
admet-850	168	5	of	of	ADP
admet-850	168	6	inand	inand	ADJ
admet-850	168	7	efflux	efflux	NOUN
admet-850	168	8	transporters	transporter	NOUN
admet-850	168	9	that	that	PRON
admet-850	168	10	have	have	VERB
admet-850	168	11	the	the	DET
admet-850	168	12	ability	ability	NOUN
admet-850	168	13	to	to	PART
admet-850	168	14	significantly	significantly	ADV
admet-850	168	15	modulate	modulate	VERB
admet-850	168	16	the	the	DET
admet-850	168	17	extent	extent	NOUN
admet-850	168	18	and	and	CCONJ
admet-850	168	19	rate	rate	NOUN
admet-850	168	20	at	at	ADP
admet-850	168	21	which	which	PRON
admet-850	168	22	a	a	DET
admet-850	168	23	drug	drug	NOUN
admet-850	168	24	substance	substance	NOUN
admet-850	168	25	becomes	become	VERB
admet-850	168	26	available	available	ADJ
admet-850	168	27	in	in	ADP
admet-850	168	28	the	the	DET
admet-850	168	29	systemic	systemic	ADJ
admet-850	168	30	circulation	circulation	NOUN
admet-850	168	31	after	after	ADP
admet-850	168	32	oral	oral	ADJ
admet-850	168	33	administration	administration	NOUN
admet-850	168	34	(=	(=	NOUN
admet-850	168	35	bioavailability	bioavailability	NOUN
admet-850	168	36	)	)	PUNCT
admet-850	168	37	may	may	AUX
admet-850	168	38	not	not	PART
admet-850	168	39	be	be	AUX
admet-850	168	40	adequately	adequately	ADV
admet-850	168	41	represented	represent	VERB
admet-850	168	42	by	by	ADP
admet-850	168	43	default	default	NOUN
admet-850	168	44	model	model	NOUN
admet-850	168	45	parameters	parameter	NOUN
admet-850	168	46	.	.	PUNCT
admet-850	169	1	similarly	similarly	ADV
admet-850	169	2	,	,	PUNCT
admet-850	169	3	gene	gene	NOUN
admet-850	169	4	polymorphism	polymorphism	NOUN
admet-850	169	5	responsible	responsible	ADJ
admet-850	169	6	for	for	ADP
admet-850	169	7	different	different	ADJ
admet-850	169	8	expression	expression	NOUN
admet-850	169	9	levels	level	NOUN
admet-850	169	10	of	of	ADP
admet-850	169	11	major	major	ADJ
admet-850	169	12	metabolism	metabolism	NOUN
admet-850	169	13	enzymes	enzyme	NOUN
admet-850	169	14	(	(	PUNCT
admet-850	169	15	see	see	VERB
admet-850	169	16	supplemental	supplemental	ADJ
admet-850	169	17	information	information	NOUN
admet-850	169	18	)	)	PUNCT
admet-850	169	19	that	that	PRON
admet-850	169	20	can	can	AUX
admet-850	169	21	lead	lead	VERB
admet-850	169	22	to	to	ADP
admet-850	169	23	variable	variable	ADJ
admet-850	169	24	pre	pre	ADJ
admet-850	169	25	-	-	ADJ
admet-850	169	26	systemic	systemic	ADJ
admet-850	169	27	elimination	elimination	NOUN
admet-850	169	28	of	of	ADP
admet-850	169	29	the	the	DET
admet-850	169	30	api	api	NOUN
admet-850	169	31	at	at	ADP
admet-850	169	32	the	the	DET
admet-850	169	33	brush	brush	NOUN
admet-850	169	34	-	-	PUNCT
admet-850	169	35	border	border	NOUN
admet-850	169	36	membrane	membrane	NOUN
admet-850	169	37	may	may	AUX
admet-850	169	38	not	not	PART
admet-850	169	39	be	be	AUX
admet-850	169	40	appropriately	appropriately	ADV
admet-850	169	41	considered	consider	VERB
admet-850	169	42	when	when	SCONJ
admet-850	169	43	using	use	VERB
admet-850	169	44	default	default	NOUN
admet-850	169	45	model	model	NOUN
admet-850	169	46	parameters	parameter	NOUN
admet-850	169	47	.	.	PUNCT
admet-850	170	1	therefore	therefore	ADV
admet-850	170	2	,	,	PUNCT
admet-850	170	3	various	various	ADJ
admet-850	170	4	research	research	NOUN
admet-850	170	5	groups	group	NOUN
admet-850	170	6	have	have	AUX
admet-850	170	7	already	already	ADV
admet-850	170	8	initiated	initiate	VERB
admet-850	170	9	comprehensive	comprehensive	ADJ
admet-850	170	10	research	research	NOUN
admet-850	170	11	studies	study	NOUN
admet-850	170	12	to	to	PART
admet-850	170	13	identify	identify	VERB
admet-850	170	14	critical	critical	ADJ
admet-850	170	15	model	model	NOUN
admet-850	170	16	input	input	NOUN
admet-850	170	17	parameters	parameter	NOUN
admet-850	170	18	that	that	PRON
admet-850	170	19	must	must	AUX
admet-850	170	20	be	be	AUX
admet-850	170	21	defined	define	VERB
admet-850	170	22	in	in	ADP
admet-850	170	23	order	order	NOUN
admet-850	170	24	to	to	PART
admet-850	170	25	enhance	enhance	VERB
admet-850	170	26	the	the	DET
admet-850	170	27	in	in	ADP
admet-850	170	28	vivo	vivo	NOUN
admet-850	170	29	relationship	relationship	NOUN
admet-850	170	30	and	and	CCONJ
admet-850	170	31	bioequivalence	bioequivalence	NOUN
admet-850	170	32	prediction	prediction	NOUN
admet-850	170	33	using	use	VERB
admet-850	170	34	pbpk	pbpk	ADJ
admet-850	170	35	absorption	absorption	NOUN
admet-850	170	36	models	model	NOUN
admet-850	170	37	[	[	X
admet-850	170	38	22,23	22,23	NOUN
admet-850	170	39	]	]	PUNCT
admet-850	170	40	.	.	PUNCT
admet-850	171	1	api	api	NOUN
admet-850	171	2	assignment	assignment	NOUN
admet-850	171	3	to	to	ADP
admet-850	171	4	who	who	PRON
admet-850	171	5	biopharmaceutical	biopharmaceutical	ADJ
admet-850	171	6	classification	classification	NOUN
admet-850	171	7	system	system	NOUN
admet-850	171	8	the	the	DET
admet-850	171	9	main	main	ADJ
admet-850	171	10	objective	objective	NOUN
admet-850	171	11	of	of	ADP
admet-850	171	12	this	this	DET
admet-850	171	13	study	study	NOUN
admet-850	171	14	was	be	AUX
admet-850	171	15	to	to	PART
admet-850	171	16	validate	validate	VERB
admet-850	171	17	provisional	provisional	ADJ
admet-850	171	18	api	api	NOUN
admet-850	171	19	classification	classification	NOUN
admet-850	171	20	performed	perform	VERB
admet-850	171	21	earlier	early	ADV
admet-850	171	22	using	use	VERB
admet-850	171	23	literature	literature	NOUN
admet-850	171	24	-	-	PUNCT
admet-850	171	25	based	base	VERB
admet-850	171	26	data	datum	NOUN
admet-850	171	27	(	(	PUNCT
admet-850	171	28	i.e.	i.e.	X
admet-850	171	29	,	,	PUNCT
admet-850	171	30	2006	2006	NUM
admet-850	171	31	who	who	PRON
admet-850	171	32	bcs	bcs	VERB
admet-850	171	33	)	)	PUNCT
admet-850	171	34	with	with	ADP
admet-850	171	35	an	an	DET
admet-850	171	36	updated	update	VERB
admet-850	171	37	experimental	experimental	ADJ
admet-850	171	38	solubility	solubility	NOUN
admet-850	171	39	assessment	assessment	NOUN
admet-850	171	40	that	that	PRON
admet-850	171	41	was	be	AUX
admet-850	171	42	based	base	VERB
admet-850	171	43	on	on	ADP
admet-850	171	44	a	a	DET
admet-850	171	45	globally	globally	ADV
admet-850	171	46	harmonized	harmonized	ADJ
admet-850	171	47	protocol	protocol	NOUN
admet-850	171	48	.	.	PUNCT
admet-850	172	1	table	table	NOUN
admet-850	172	2	4	4	NUM
admet-850	172	3	summarizes	summarize	NOUN
admet-850	172	4	the	the	DET
admet-850	172	5	results	result	NOUN
admet-850	172	6	from	from	ADP
admet-850	172	7	this	this	DET
admet-850	172	8	study	study	NOUN
admet-850	172	9	and	and	CCONJ
admet-850	172	10	compares	compare	VERB
admet-850	172	11	provisional	provisional	ADJ
admet-850	172	12	api	api	NOUN
admet-850	172	13	assignments	assignment	NOUN
admet-850	172	14	to	to	ADP
admet-850	172	15	the	the	PRON
admet-850	172	16	who	who	PRON
admet-850	172	17	bcs	bc	VERB
admet-850	172	18	.	.	PUNCT
admet-850	173	1	completion	completion	NOUN
admet-850	173	2	of	of	ADP
admet-850	173	3	equilibrium	equilibrium	NOUN
admet-850	173	4	solubility	solubility	NOUN
admet-850	173	5	experiments	experiment	NOUN
admet-850	173	6	by	by	ADP
admet-850	173	7	a	a	DET
admet-850	173	8	consortium	consortium	NOUN
admet-850	173	9	of	of	ADP
admet-850	173	10	10	10	NUM
admet-850	173	11	international	international	ADJ
admet-850	173	12	laboratories	laboratory	NOUN
admet-850	173	13	located	locate	VERB
admet-850	173	14	in	in	ADP
admet-850	173	15	different	different	ADJ
admet-850	173	16	who	who	PRON
admet-850	173	17	regions	region	NOUN
admet-850	173	18	provided	provide	VERB
admet-850	173	19	the	the	DET
admet-850	173	20	scientific	scientific	ADJ
admet-850	173	21	basis	basis	NOUN
admet-850	173	22	to	to	PART
admet-850	173	23	change	change	VERB
admet-850	173	24	the	the	DET
admet-850	173	25	solubility	solubility	NOUN
admet-850	173	26	designation	designation	NOUN
admet-850	173	27	from	from	ADP
admet-850	173	28	“	"	PUNCT
admet-850	173	29	high	high	ADJ
admet-850	173	30	solubility	solubility	NOUN
admet-850	173	31	”	"	PUNCT
admet-850	173	32	to	to	ADP
admet-850	173	33	“	"	PUNCT
admet-850	173	34	low	low	ADJ
admet-850	173	35	solubility	solubility	NOUN
admet-850	173	36	”	"	PUNCT
admet-850	173	37	for	for	ADP
admet-850	173	38	aciclovir	aciclovir	PROPN
admet-850	173	39	,	,	PUNCT
admet-850	173	40	amoxicillin	amoxicillin	NOUN
admet-850	173	41	,	,	PUNCT
admet-850	173	42	and	and	CCONJ
admet-850	173	43	ethionamide	ethionamide	NOUN
admet-850	173	44	.	.	PUNCT
admet-850	174	1	this	this	DET
admet-850	174	2	result	result	NOUN
admet-850	174	3	may	may	AUX
admet-850	174	4	have	have	AUX
admet-850	174	5	been	be	AUX
admet-850	174	6	the	the	DET
admet-850	174	7	consequence	consequence	NOUN
admet-850	174	8	of	of	ADP
admet-850	174	9	updated	update	VERB
admet-850	174	10	highest	high	ADJ
admet-850	174	11	therapeutic	therapeutic	ADJ
admet-850	174	12	dose	dose	NOUN
admet-850	174	13	values	value	NOUN
admet-850	174	14	when	when	SCONJ
admet-850	174	15	compared	compare	VERB
admet-850	174	16	to	to	ADP
admet-850	174	17	the	the	DET
admet-850	174	18	provisional	provisional	ADJ
admet-850	174	19	2006	2006	NUM
admet-850	174	20	who	who	PRON
admet-850	174	21	bcs	bc	VERB
admet-850	174	22	classification	classification	NOUN
admet-850	174	23	.	.	PUNCT
admet-850	175	1	in	in	ADP
admet-850	175	2	addition	addition	NOUN
admet-850	175	3	,	,	PUNCT
admet-850	175	4	the	the	DET
admet-850	175	5	results	result	NOUN
admet-850	175	6	from	from	ADP
admet-850	175	7	this	this	DET
admet-850	175	8	study	study	NOUN
admet-850	175	9	provided	provide	VERB
admet-850	175	10	qualified	qualified	ADJ
admet-850	175	11	solubility	solubility	NOUN
admet-850	175	12	data	datum	NOUN
admet-850	175	13	for	for	ADP
admet-850	175	14	five	five	NUM
admet-850	175	15	apis	apis	ADJ
admet-850	175	16	(	(	PUNCT
admet-850	175	17	i.e.	i.e.	X
admet-850	175	18	,	,	PUNCT
admet-850	175	19	daclatasvir	daclatasvir	PROPN
admet-850	175	20	,	,	PUNCT
admet-850	175	21	darunavir	darunavir	PROPN
admet-850	175	22	,	,	PUNCT
admet-850	175	23	dolutegravir	dolutegravir	PROPN
admet-850	175	24	,	,	PUNCT
admet-850	175	25	raltegravir	raltegravir	PROPN
admet-850	175	26	,	,	PUNCT
admet-850	175	27	and	and	CCONJ
admet-850	175	28	tenofovir	tenofovir	NOUN
admet-850	175	29	disoproxil	disoproxil	VERB
admet-850	175	30	fumarate	fumarate	NOUN
admet-850	175	31	)	)	PUNCT
admet-850	175	32	that	that	PRON
admet-850	175	33	were	be	AUX
admet-850	175	34	not	not	PART
admet-850	175	35	considered	consider	VERB
admet-850	175	36	during	during	ADP
admet-850	175	37	the	the	DET
admet-850	175	38	previous	previous	ADJ
admet-850	175	39	who	who	PRON
admet-850	175	40	bcs	bc	VERB
admet-850	175	41	assignment	assignment	NOUN
admet-850	175	42	in	in	ADP
admet-850	175	43	2006	2006	NUM
admet-850	175	44	.	.	PUNCT
admet-850	176	1	for	for	ADP
admet-850	176	2	the	the	DET
admet-850	176	3	remaining	remain	VERB
admet-850	176	4	six	six	NUM
admet-850	176	5	apis	apis	ADJ
admet-850	176	6	,	,	PUNCT
admet-850	176	7	experimental	experimental	ADJ
admet-850	176	8	solubility	solubility	NOUN
admet-850	176	9	assessment	assessment	NOUN
admet-850	176	10	confirmed	confirm	VERB
admet-850	176	11	the	the	DET
admet-850	176	12	earlier	early	ADJ
admet-850	176	13	solubility	solubility	NOUN
admet-850	176	14	classification	classification	NOUN
admet-850	176	15	based	base	VERB
admet-850	176	16	on	on	ADP
admet-850	176	17	literature	literature	NOUN
admet-850	176	18	data	datum	NOUN
admet-850	176	19	.	.	PUNCT
admet-850	177	1	however	however	ADV
admet-850	177	2	,	,	PUNCT
admet-850	177	3	due	due	ADJ
admet-850	177	4	the	the	DET
admet-850	177	5	experimental	experimental	ADJ
admet-850	177	6	difficulty	difficulty	NOUN
admet-850	177	7	to	to	PART
admet-850	177	8	directly	directly	ADV
admet-850	177	9	assess	assess	VERB
admet-850	177	10	fa	fa	PROPN
admet-850	177	11	in	in	ADP
admet-850	177	12	humans	human	NOUN
admet-850	177	13	,	,	PUNCT
admet-850	177	14	the	the	DET
admet-850	177	15	research	research	NOUN
admet-850	177	16	community	community	NOUN
admet-850	177	17	is	be	AUX
admet-850	177	18	faced	face	VERB
admet-850	177	19	with	with	ADP
admet-850	177	20	widespread	widespread	ADJ
admet-850	177	21	uncertainty	uncertainty	NOUN
admet-850	177	22	regarding	regard	VERB
admet-850	177	23	the	the	DET
admet-850	177	24	most	most	ADV
admet-850	177	25	appropriate	appropriate	ADJ
admet-850	177	26	methodology	methodology	NOUN
admet-850	177	27	to	to	PART
admet-850	177	28	consistently	consistently	ADV
admet-850	177	29	categorize	categorize	VERB
admet-850	177	30	apis	apis	PROPN
admet-850	177	31	as	as	ADP
admet-850	177	32	“	"	PUNCT
admet-850	177	33	high	high	ADJ
admet-850	177	34	permeability	permeability	NOUN
admet-850	177	35	”	"	PUNCT
admet-850	177	36	or	or	CCONJ
admet-850	177	37	“	"	PUNCT
admet-850	177	38	low	low	ADJ
admet-850	177	39	permeability	permeability	NOUN
admet-850	177	40	”	"	PUNCT
admet-850	177	41	drugs	drug	NOUN
admet-850	177	42	[	[	X
admet-850	177	43	39	39	NUM
admet-850	177	44	]	]	PUNCT
admet-850	177	45	.	.	PUNCT
admet-850	178	1	provisional	provisional	ADJ
admet-850	178	2	classification	classification	NOUN
admet-850	178	3	of	of	ADP
admet-850	178	4	apis	apis	PROPN
admet-850	178	5	according	accord	VERB
admet-850	178	6	to	to	ADP
admet-850	178	7	the	the	PRON
admet-850	178	8	who	who	PRON
admet-850	178	9	bcs	bcs	VERB
admet-850	178	10	in	in	ADP
admet-850	178	11	2006	2006	NUM
admet-850	179	1	[	[	X
admet-850	179	2	6	6	NUM
admet-850	179	3	]	]	PUNCT
admet-850	179	4	was	be	AUX
admet-850	179	5	exclusively	exclusively	ADV
admet-850	179	6	based	base	VERB
admet-850	179	7	on	on	ADP
admet-850	179	8	literature	literature	NOUN
admet-850	179	9	data	datum	NOUN
admet-850	179	10	.	.	PUNCT
admet-850	180	1	ambiguity	ambiguity	NOUN
admet-850	180	2	regarding	regard	VERB
admet-850	180	3	the	the	DET
admet-850	180	4	permeability	permeability	NOUN
admet-850	180	5	classification	classification	NOUN
admet-850	180	6	was	be	AUX
admet-850	180	7	noted	note	VERB
admet-850	180	8	in	in	ADP
admet-850	180	9	28.2	28.2	NUM
admet-850	180	10	%	%	NOUN
admet-850	180	11	of	of	ADP
admet-850	180	12	all	all	DET
admet-850	180	13	131	131	NUM
admet-850	180	14	apis	apis	PROPN
admet-850	180	15	examined	examine	VERB
admet-850	180	16	.	.	PUNCT
admet-850	181	1	admet	admet	PROPN
admet-850	181	2	&	&	CCONJ
admet-850	181	3	dmpk	dmpk	PROPN
admet-850	181	4	9(1	9(1	NUM
admet-850	181	5	)	)	PUNCT
admet-850	181	6	(	(	PUNCT
admet-850	181	7	2021	2021	NUM
admet-850	181	8	)	)	PUNCT
admet-850	181	9	23	23	NUM
admet-850	181	10	-	-	SYM
admet-850	181	11	39	39	NUM
admet-850	181	12	enhancing	enhance	VERB
admet-850	181	13	robustness	robustness	NOUN
admet-850	181	14	of	of	ADP
admet-850	181	15	the	the	PRON
admet-850	181	16	who	who	PRON
admet-850	181	17	biopharmaceutical	biopharmaceutical	ADJ
admet-850	181	18	classification	classification	NOUN
admet-850	181	19	system	system	NOUN
admet-850	181	20	doi	doi	NOUN
admet-850	181	21	:	:	PUNCT
admet-850	181	22	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	NOUN
admet-850	181	23	35	35	NUM
admet-850	181	24	table	table	NOUN
admet-850	181	25	4	4	NUM
admet-850	181	26	.	.	PUNCT
admet-850	181	27	comparison	comparison	NOUN
admet-850	181	28	of	of	ADP
admet-850	181	29	provisional	provisional	ADJ
admet-850	181	30	api	api	NOUN
admet-850	181	31	assignment	assignment	NOUN
admet-850	181	32	to	to	ADP
admet-850	181	33	who	who	PRON
admet-850	181	34	bcs	bcs	VERB
admet-850	181	35	api	api	NOUN
admet-850	181	36	highest	highest	ADV
admet-850	181	37	therapeutic	therapeutic	ADJ
admet-850	181	38	dose	dose	NOUN
admet-850	181	39	[	[	X
admet-850	181	40	mg	mg	X
admet-850	181	41	]	]	X
admet-850	181	42	a	a	DET
admet-850	181	43	provisional	provisional	ADJ
admet-850	181	44	2006	2006	NUM
admet-850	181	45	who	who	PRON
admet-850	181	46	bcs	bc	VERB
admet-850	181	47	b	b	DET
admet-850	181	48	experimentally	experimentally	ADV
admet-850	181	49	assigned	assign	VERB
admet-850	181	50	solubility	solubility	NOUN
admet-850	181	51	class	class	NOUN
admet-850	181	52	gastroplus	gastroplus	NOUN
admet-850	181	53	©	©	PROPN
admet-850	181	54	predicted	predict	VERB
admet-850	181	55	fraction	fraction	NOUN
admet-850	181	56	absorbed	absorb	VERB
admet-850	181	57	in	in	ADP
admet-850	181	58	humans	human	NOUN
admet-850	181	59	oral	oral	ADJ
admet-850	181	60	bioavailability	bioavailability	NOUN
admet-850	181	61	in	in	ADP
admet-850	181	62	humans	human	NOUN
admet-850	182	1	[	[	X
admet-850	182	2	%	%	X
admet-850	182	3	]	]	X
admet-850	182	4	c	c	NOUN
admet-850	182	5	provisional	provisional	ADJ
admet-850	182	6	2020	2020	NUM
admet-850	182	7	who	who	PRON
admet-850	182	8	bcs	bc	VERB
admet-850	182	9	aciclovir	aciclovir	CCONJ
admet-850	182	10	800	800	NUM
admet-850	182	11	iii	iii	NUM
admet-850	183	1	ls	ls	INTJ
admet-850	183	2	lp	lp	PROPN
admet-850	183	3	*	*	NUM
admet-850	183	4	20.0	20.0	NUM
admet-850	183	5	[	[	X
admet-850	183	6	24	24	NUM
admet-850	183	7	]	]	SYM
admet-850	183	8	iv	iv	NUM
admet-850	183	9	amoxicillin	amoxicillin	NOUN
admet-850	183	10	trihydrate	trihydrate	VERB
admet-850	183	11	3000	3000	NUM
admet-850	184	1	i	i	PRON
admet-850	184	2	ls	ls	VERB
admet-850	184	3	lp	lp	ADP
admet-850	184	4	45.0	45.0	NUM
admet-850	185	1	[	[	X
admet-850	185	2	19	19	NUM
admet-850	185	3	]	]	SYM
admet-850	185	4	iv	iv	NUM
admet-850	185	5	azithromycin	azithromycin	NOUN
admet-850	185	6	dihydrate	dihydrate	NOUN
admet-850	185	7	2000	2000	NUM
admet-850	185	8	iv	iv	NUM
admet-850	185	9	/	/	SYM
admet-850	185	10	ii	ii	PROPN
admet-850	185	11	ls	ls	NOUN
admet-850	185	12	lp	lp	PROPN
admet-850	185	13	*	*	NUM
admet-850	185	14	37.0	37.0	NUM
admet-850	186	1	[	[	X
admet-850	186	2	25	25	NUM
admet-850	186	3	]	]	SYM
admet-850	186	4	iv	iv	NUM
admet-850	186	5	cefixime	cefixime	ADJ
admet-850	186	6	trihydrate	trihydrate	NOUN
admet-850	186	7	400	400	NUM
admet-850	186	8	iv	iv	NOUN
admet-850	186	9	ls	ls	NOUN
admet-850	186	10	lp	lp	NOUN
admet-850	186	11	40.2	40.2	NUM
admet-850	187	1	[	[	X
admet-850	187	2	26	26	NUM
admet-850	187	3	]	]	SYM
admet-850	187	4	iv	iv	NUM
admet-850	187	5	codeine	codeine	NOUN
admet-850	187	6	phosphate	phosphate	NOUN
admet-850	187	7	semihydrate	semihydrate	NOUN
admet-850	187	8	60	60	NUM
admet-850	187	9	iii	iii	X
admet-850	187	10	hs	hs	PROPN
admet-850	187	11	hp	hp	VERB
admet-850	187	12	54.8	54.8	NUM
admet-850	187	13	[	[	X
admet-850	187	14	27	27	NUM
admet-850	187	15	]	]	X
admet-850	187	16	i	i	PROPN
admet-850	187	17	/	/	SYM
admet-850	187	18	iii	iii	PROPN
admet-850	187	19	daclatasvir	daclatasvir	NOUN
admet-850	187	20	dihydrochloride	dihydrochloride	VERB
admet-850	187	21	60	60	NUM
admet-850	187	22	not	not	PART
admet-850	187	23	classified	classify	VERB
admet-850	187	24	ls	ls	ADJ
admet-850	187	25	hp	hp	PROPN
admet-850	187	26	67.0	67.0	NUM
admet-850	187	27	[	[	X
admet-850	187	28	28	28	NUM
admet-850	187	29	]	]	SYM
admet-850	187	30	ii	ii	PROPN
admet-850	187	31	/	/	SYM
admet-850	187	32	iv	iv	PROPN
admet-850	187	33	darunavir	darunavir	PROPN
admet-850	187	34	ethanolate	ethanolate	VERB
admet-850	187	35	800	800	NUM
admet-850	187	36	not	not	PART
admet-850	187	37	classified	classify	VERB
admet-850	187	38	ls	ls	ADJ
admet-850	187	39	lp	lp	PROPN
admet-850	187	40	*	*	NUM
admet-850	187	41	37.0	37.0	NUM
admet-850	188	1	[	[	X
admet-850	188	2	29	29	NUM
admet-850	188	3	]	]	SYM
admet-850	188	4	iv	iv	NUM
admet-850	188	5	dolutegravir	dolutegravir	NOUN
admet-850	188	6	50	50	NUM
admet-850	188	7	not	not	PART
admet-850	188	8	classified	classify	VERB
admet-850	188	9	ls	ls	ADJ
admet-850	188	10	hp	hp	PROPN
admet-850	188	11	31.0	31.0	NUM
admet-850	188	12	[	[	NOUN
admet-850	188	13	30	30	NUM
admet-850	188	14	]	]	SYM
admet-850	188	15	ii	ii	PROPN
admet-850	188	16	/	/	SYM
admet-850	188	17	iv	iv	NUM
admet-850	188	18	efavirenz	efavirenz	NOUN
admet-850	188	19	600	600	NUM
admet-850	188	20	ii	ii	NOUN
admet-850	188	21	/	/	SYM
admet-850	188	22	iv	iv	PROPN
admet-850	188	23	ls	ls	PROPN
admet-850	188	24	lp	lp	ADJ
admet-850	188	25	19.5	19.5	NUM
admet-850	189	1	[	[	X
admet-850	189	2	31	31	NUM
admet-850	189	3	]	]	SYM
admet-850	189	4	iv	iv	NUM
admet-850	189	5	ethionamide	ethionamide	ADV
admet-850	189	6	500–1000	500–1000	NUM
admet-850	189	7	iii	iii	NOUN
admet-850	189	8	/	/	SYM
admet-850	189	9	i	i	PRON
admet-850	189	10	ls	ls	PROPN
admet-850	189	11	hp	hp	PROPN
admet-850	189	12	*	*	PUNCT
admet-850	189	13	83.3	83.3	NUM
admet-850	189	14	[	[	PUNCT
admet-850	189	15	32	32	NUM
admet-850	189	16	]	]	SYM
admet-850	189	17	ii	ii	PROPN
admet-850	189	18	/	/	SYM
admet-850	189	19	iv	iv	NOUN
admet-850	189	20	furosemide	furosemide	VERB
admet-850	189	21	80	80	NUM
admet-850	189	22	iv	iv	NUM
admet-850	189	23	/	/	SYM
admet-850	189	24	ii	ii	PROPN
admet-850	189	25	ls	ls	NOUN
admet-850	189	26	lp	lp	PROPN
admet-850	189	27	*	*	NUM
admet-850	189	28	42.8	42.8	NUM
admet-850	190	1	[	[	X
admet-850	190	2	33	33	NUM
admet-850	190	3	]	]	SYM
admet-850	190	4	iv	iv	NUM
admet-850	190	5	primaquine	primaquine	NOUN
admet-850	190	6	phosphate	phosphate	NOUN
admet-850	190	7	15	15	NUM
admet-850	191	1	i	i	PRON
admet-850	191	2	hs	hs	PROPN
admet-850	191	3	hp	hp	VERB
admet-850	191	4	96.0	96.0	NUM
admet-850	191	5	[	[	X
admet-850	191	6	34	34	NUM
admet-850	191	7	]	]	X
admet-850	191	8	i	i	PRON
admet-850	191	9	pyrimethamine	pyrimethamine	VERB
admet-850	191	10	75	75	NUM
admet-850	191	11	iv	iv	NUM
admet-850	191	12	/	/	SYM
admet-850	191	13	iii	iii	NUM
admet-850	191	14	ls	ls	PROPN
admet-850	191	15	hp	hp	PROPN
admet-850	191	16	*	*	PUNCT
admet-850	191	17	50.0	50.0	NUM
admet-850	191	18	[	[	SYM
admet-850	191	19	35	35	NUM
admet-850	191	20	]	]	SYM
admet-850	191	21	ii	ii	PROPN
admet-850	191	22	/	/	SYM
admet-850	191	23	iv	iv	PROPN
admet-850	191	24	raltegravir	raltegravir	PROPN
admet-850	191	25	potassium	potassium	VERB
admet-850	191	26	400	400	NUM
admet-850	191	27	not	not	PART
admet-850	191	28	classified	classify	VERB
admet-850	191	29	ls	ls	ADJ
admet-850	191	30	hp	hp	PROPN
admet-850	191	31	30.0	30.0	NUM
admet-850	191	32	[	[	SYM
admet-850	191	33	36	36	NUM
admet-850	191	34	]	]	SYM
admet-850	191	35	ii	ii	PROPN
admet-850	191	36	/	/	SYM
admet-850	191	37	iv	iv	PROPN
admet-850	191	38	rifampicin	rifampicin	VERB
admet-850	191	39	750	750	NUM
admet-850	191	40	ii	ii	NOUN
admet-850	191	41	ls	ls	INTJ
admet-850	191	42	lp	lp	PROPN
admet-850	191	43	*	*	NUM
admet-850	191	44	93	93	NUM
admet-850	192	1	[	[	X
admet-850	192	2	37	37	NUM
admet-850	192	3	]	]	SYM
admet-850	192	4	ii	ii	PROPN
admet-850	192	5	/	/	SYM
admet-850	192	6	iv	iv	PROPN
admet-850	192	7	tenofovir	tenofovir	NOUN
admet-850	192	8	disoproxil	disoproxil	VERB
admet-850	192	9	fumarate	fumarate	NOUN
admet-850	192	10	300	300	NUM
admet-850	192	11	not	not	PART
admet-850	192	12	classified	classify	VERB
admet-850	192	13	hs	hs	PROPN
admet-850	192	14	lp	lp	PROPN
admet-850	192	15	25	25	NUM
admet-850	192	16	[	[	X
admet-850	192	17	38	38	NUM
admet-850	192	18	]	]	SYM
admet-850	192	19	iii	iii	X
admet-850	192	20	a	a	DET
admet-850	192	21	according	accord	VERB
admet-850	192	22	to	to	ADP
admet-850	192	23	summary	summary	NOUN
admet-850	192	24	of	of	ADP
admet-850	192	25	product	product	NOUN
admet-850	192	26	characteristics	characteristic	NOUN
admet-850	192	27	from	from	ADP
admet-850	192	28	who	who	PRON
admet-850	192	29	-	-	PUNCT
admet-850	192	30	pq	pq	NOUN
admet-850	192	31	or	or	CCONJ
admet-850	192	32	national	national	ADJ
admet-850	192	33	/	/	SYM
admet-850	192	34	regional	regional	ADJ
admet-850	192	35	regulatory	regulatory	ADJ
admet-850	192	36	authority	authority	NOUN
admet-850	192	37	.	.	PUNCT
admet-850	193	1	b	b	X
admet-850	193	2	proposal	proposal	NOUN
admet-850	193	3	to	to	PART
admet-850	193	4	waive	waive	VERB
admet-850	193	5	in	in	ADP
admet-850	193	6	vivo	vivo	ADJ
admet-850	193	7	bioequivalence	bioequivalence	NOUN
admet-850	193	8	requirements	requirement	NOUN
admet-850	193	9	for	for	ADP
admet-850	193	10	who	who	PRON
admet-850	193	11	model	model	NOUN
admet-850	193	12	list	list	NOUN
admet-850	193	13	of	of	ADP
admet-850	193	14	essential	essential	ADJ
admet-850	193	15	medicines	medicine	NOUN
admet-850	193	16	immediate	immediate	ADJ
admet-850	193	17	-	-	PUNCT
admet-850	193	18	release	release	NOUN
admet-850	193	19	,	,	PUNCT
admet-850	193	20	solid	solid	ADJ
admet-850	193	21	oral	oral	ADJ
admet-850	193	22	dosage	dosage	NOUN
admet-850	193	23	forms	form	NOUN
admet-850	193	24	.	.	PUNCT
admet-850	194	1	in	in	ADP
admet-850	194	2	:	:	PUNCT
admet-850	194	3	who	who	PRON
admet-850	194	4	expert	expert	ADJ
admet-850	194	5	committee	committee	NOUN
admet-850	194	6	on	on	ADP
admet-850	194	7	specifications	specification	NOUN
admet-850	194	8	for	for	ADP
admet-850	194	9	pharmaceutical	pharmaceutical	ADJ
admet-850	194	10	preparations	preparation	NOUN
admet-850	194	11	:	:	PUNCT
admet-850	194	12	fortieth	fortieth	ADJ
admet-850	194	13	report	report	NOUN
admet-850	194	14	.	.	PUNCT
admet-850	195	1	geneva	geneva	PROPN
admet-850	195	2	:	:	PUNCT
admet-850	195	3	world	world	PROPN
admet-850	195	4	health	health	NOUN
admet-850	195	5	organization	organization	NOUN
admet-850	195	6	;	;	PUNCT
admet-850	195	7	2006	2006	NUM
admet-850	195	8	:	:	PUNCT
admet-850	195	9	annex	annex	VERB
admet-850	195	10	8	8	NUM
admet-850	195	11	(	(	PUNCT
admet-850	195	12	who	who	PRON
admet-850	195	13	technical	technical	ADJ
admet-850	195	14	report	report	NOUN
admet-850	195	15	series	series	NOUN
admet-850	195	16	,	,	PUNCT
admet-850	195	17	no	no	INTJ
admet-850	195	18	.	.	PROPN
admet-850	195	19	937	937	NUM
admet-850	195	20	;	;	PUNCT
admet-850	195	21	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedici	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedici	NOUN
admet-850	195	22	nesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	nesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	195	23	,	,	PUNCT
admet-850	195	24	accessed	access	VERB
admet-850	195	25	4	4	NUM
admet-850	195	26	may	may	NOUN
admet-850	195	27	2020	2020	NUM
admet-850	195	28	)	)	PUNCT
admet-850	195	29	.	.	PUNCT
admet-850	196	1	updated	update	VERB
admet-850	196	2	requirement	requirement	NOUN
admet-850	196	3	in	in	ADP
admet-850	196	4	:	:	PUNCT
admet-850	196	5	multisource	multisource	ADJ
admet-850	196	6	(	(	PUNCT
admet-850	196	7	generic	generic	ADJ
admet-850	196	8	)	)	PUNCT
admet-850	196	9	pharmaceutical	pharmaceutical	NOUN
admet-850	196	10	products	product	NOUN
admet-850	196	11	:	:	PUNCT
admet-850	196	12	guidelines	guideline	NOUN
admet-850	196	13	on	on	ADP
admet-850	196	14	registration	registration	NOUN
admet-850	196	15	requirements	requirement	NOUN
admet-850	196	16	to	to	PART
admet-850	196	17	establish	establish	VERB
admet-850	196	18	interchangeability	interchangeability	NOUN
admet-850	196	19	.	.	PUNCT
admet-850	197	1	in	in	ADP
admet-850	197	2	:	:	PUNCT
admet-850	197	3	who	who	PRON
admet-850	197	4	expert	expert	ADJ
admet-850	197	5	committee	committee	NOUN
admet-850	197	6	on	on	ADP
admet-850	197	7	specifications	specification	NOUN
admet-850	197	8	for	for	ADP
admet-850	197	9	pharmaceutical	pharmaceutical	ADJ
admet-850	197	10	preparations	preparation	NOUN
admet-850	197	11	:	:	PUNCT
admet-850	197	12	fifty	fifty	NUM
admet-850	197	13	-	-	PUNCT
admet-850	197	14	first	first	ADJ
admet-850	197	15	report	report	NOUN
admet-850	197	16	.	.	PUNCT
admet-850	198	1	geneva	geneva	NOUN
admet-850	198	2	:	:	PUNCT
admet-850	198	3	world	world	PROPN
admet-850	198	4	health	health	NOUN
admet-850	198	5	organization	organization	NOUN
admet-850	198	6	;	;	PUNCT
admet-850	198	7	2017	2017	NUM
admet-850	198	8	:	:	PUNCT
admet-850	198	9	annex	annex	VERB
admet-850	198	10	6	6	NUM
admet-850	198	11	(	(	PUNCT
admet-850	198	12	who	who	PRON
admet-850	198	13	technical	technical	ADJ
admet-850	198	14	report	report	NOUN
admet-850	198	15	series	series	NOUN
admet-850	198	16	,	,	PUNCT
admet-850	198	17	no	no	INTJ
admet-850	198	18	.	.	NOUN
admet-850	198	19	1003	1003	NUM
admet-850	198	20	;	;	PUNCT
admet-850	198	21	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	NOUN
admet-850	198	22	,	,	PUNCT
admet-850	198	23	accessed	access	VERB
admet-850	198	24	2	2	NUM
admet-850	198	25	oct	oct	NOUN
admet-850	198	26	2020	2020	NUM
admet-850	198	27	)	)	PUNCT
admet-850	198	28	.	.	PUNCT
admet-850	199	1	c	c	PROPN
admet-850	199	2	oral	oral	ADJ
admet-850	199	3	bioavailability	bioavailability	NOUN
admet-850	199	4	data	datum	NOUN
admet-850	199	5	were	be	AUX
admet-850	199	6	obtained	obtain	VERB
admet-850	199	7	from	from	ADP
admet-850	199	8	the	the	DET
admet-850	199	9	primary	primary	ADJ
admet-850	199	10	literature	literature	NOUN
admet-850	199	11	.	.	PUNCT
admet-850	200	1	ls	l	VERB
admet-850	200	2	=	=	NOUN
admet-850	200	3	low	low	PROPN
admet-850	200	4	solubility	solubility	NOUN
admet-850	200	5	;	;	PUNCT
admet-850	200	6	hs	hs	PROPN
admet-850	200	7	=	=	PROPN
admet-850	200	8	high	high	ADJ
admet-850	200	9	solubility	solubility	NOUN
admet-850	200	10	;	;	PUNCT
admet-850	200	11	lp	lp	NOUN
admet-850	200	12	=	=	SYM
admet-850	200	13	low	low	ADJ
admet-850	200	14	permeability	permeability	NOUN
admet-850	200	15	;	;	PUNCT
admet-850	200	16	hp	hp	NOUN
admet-850	200	17	=	=	SYM
admet-850	200	18	high	high	ADJ
admet-850	200	19	permeability	permeability	NOUN
admet-850	200	20	*	*	PUNCT
admet-850	200	21	clinical	clinical	ADJ
admet-850	200	22	bioavailability	bioavailability	NOUN
admet-850	200	23	data	datum	NOUN
admet-850	200	24	using	use	VERB
admet-850	200	25	an	an	DET
admet-850	200	26	oral	oral	ADJ
admet-850	200	27	dose	dose	NOUN
admet-850	200	28	different	different	ADJ
admet-850	200	29	than	than	ADP
admet-850	200	30	the	the	DET
admet-850	200	31	highest	high	ADJ
admet-850	200	32	therapeutic	therapeutic	ADJ
admet-850	200	33	dose	dose	NOUN
admet-850	200	34	listed	list	VERB
admet-850	200	35	in	in	ADP
admet-850	200	36	table	table	NOUN
admet-850	200	37	1	1	NUM
admet-850	200	38	to	to	PART
admet-850	200	39	explore	explore	VERB
admet-850	200	40	alternative	alternative	ADJ
admet-850	200	41	options	option	NOUN
admet-850	200	42	that	that	PRON
admet-850	200	43	may	may	AUX
admet-850	200	44	overcome	overcome	VERB
admet-850	200	45	limitations	limitation	NOUN
admet-850	200	46	of	of	ADP
admet-850	200	47	literature	literature	NOUN
admet-850	200	48	-	-	PUNCT
admet-850	200	49	based	base	VERB
admet-850	200	50	permeability	permeability	NOUN
admet-850	200	51	classification	classification	NOUN
admet-850	200	52	,	,	PUNCT
admet-850	200	53	various	various	ADJ
admet-850	200	54	research	research	NOUN
admet-850	200	55	groups	group	NOUN
admet-850	200	56	have	have	AUX
admet-850	200	57	reported	report	VERB
admet-850	200	58	the	the	DET
admet-850	200	59	use	use	NOUN
admet-850	200	60	of	of	ADP
admet-850	200	61	computational	computational	ADJ
admet-850	200	62	pbpk	pbpk	ADJ
admet-850	200	63	absorption	absorption	NOUN
admet-850	200	64	models	model	NOUN
admet-850	200	65	for	for	ADP
admet-850	200	66	bioequivalence	bioequivalence	NOUN
admet-850	200	67	predictions	prediction	NOUN
admet-850	200	68	[	[	X
admet-850	200	69	22,23	22,23	NOUN
admet-850	200	70	]	]	PUNCT
admet-850	200	71	.	.	PUNCT
admet-850	201	1	in	in	ADP
admet-850	201	2	this	this	DET
admet-850	201	3	study	study	NOUN
admet-850	201	4	,	,	PUNCT
admet-850	201	5	the	the	DET
admet-850	201	6	gastroplus	gastroplus	ADJ
admet-850	201	7	©	©	PROPN
admet-850	201	8	platform	platform	NOUN
admet-850	201	9	was	be	AUX
admet-850	201	10	used	use	VERB
admet-850	201	11	as	as	ADP
admet-850	201	12	an	an	DET
admet-850	201	13	example	example	NOUN
admet-850	201	14	to	to	PART
admet-850	201	15	illustrate	illustrate	VERB
admet-850	201	16	the	the	DET
admet-850	201	17	potential	potential	NOUN
admet-850	201	18	of	of	ADP
admet-850	201	19	a	a	DET
admet-850	201	20	bottom	bottom	NOUN
admet-850	201	21	-	-	PUNCT
admet-850	201	22	up	up	ADP
admet-850	201	23	pbpk	pbpk	PROPN
admet-850	201	24	simulation	simulation	NOUN
admet-850	201	25	tool	tool	NOUN
admet-850	201	26	when	when	SCONJ
admet-850	201	27	exploring	explore	VERB
admet-850	201	28	bcs	bcs	NOUN
admet-850	201	29	classification	classification	NOUN
admet-850	201	30	of	of	ADP
admet-850	201	31	apis	apis	PROPN
admet-850	201	32	,	,	PUNCT
admet-850	201	33	particularly	particularly	ADV
admet-850	201	34	in	in	ADP
admet-850	201	35	situations	situation	NOUN
admet-850	201	36	when	when	SCONJ
admet-850	201	37	clinical	clinical	ADJ
admet-850	201	38	bioavailability	bioavailability	NOUN
admet-850	201	39	data	datum	NOUN
admet-850	201	40	are	be	AUX
admet-850	201	41	not	not	PART
admet-850	201	42	available	available	ADJ
admet-850	201	43	.	.	PUNCT
admet-850	202	1	the	the	DET
admet-850	202	2	results	result	NOUN
admet-850	202	3	from	from	ADP
admet-850	202	4	this	this	PRON
admet-850	202	5	in	in	ADP
admet-850	202	6	silico	silico	NOUN
admet-850	202	7	exercise	exercise	NOUN
admet-850	202	8	are	be	AUX
admet-850	202	9	consistent	consistent	ADJ
admet-850	202	10	with	with	ADP
admet-850	202	11	previous	previous	ADJ
admet-850	202	12	literature	literature	NOUN
admet-850	202	13	-	-	PUNCT
admet-850	202	14	based	base	VERB
admet-850	202	15	permeability	permeability	NOUN
admet-850	202	16	assignments	assignment	NOUN
admet-850	202	17	for	for	ADP
admet-850	202	18	aciclovir	aciclovir	PROPN
admet-850	202	19	,	,	PUNCT
admet-850	202	20	furosemide	furosemide	ADJ
admet-850	202	21	,	,	PUNCT
admet-850	202	22	and	and	CCONJ
admet-850	202	23	primaquine	primaquine	NOUN
admet-850	202	24	.	.	PUNCT
admet-850	203	1	furthermore	furthermore	ADV
admet-850	203	2	,	,	PUNCT
admet-850	203	3	adoption	adoption	NOUN
admet-850	203	4	of	of	ADP
admet-850	203	5	this	this	PRON
admet-850	203	6	a	a	DET
admet-850	203	7	priori	priori	X
admet-850	203	8	modeling	modeling	NOUN
admet-850	203	9	approach	approach	NOUN
admet-850	203	10	using	use	VERB
admet-850	203	11	default	default	NOUN
admet-850	203	12	gastroplus	gastroplus	ADJ
admet-850	203	13	©	©	PROPN
admet-850	203	14	input	input	NOUN
admet-850	203	15	parameters	parameter	NOUN
admet-850	203	16	(	(	PUNCT
admet-850	203	17	see	see	VERB
admet-850	203	18	table	table	NOUN
admet-850	203	19	2	2	NUM
admet-850	203	20	)	)	PUNCT
admet-850	203	21	,	,	PUNCT
admet-850	203	22	combined	combine	VERB
admet-850	203	23	with	with	ADP
admet-850	203	24	clinical	clinical	ADJ
admet-850	203	25	bioavailability	bioavailability	NOUN
admet-850	203	26	data	datum	NOUN
admet-850	203	27	generated	generate	VERB
admet-850	203	28	for	for	ADP
admet-850	203	29	different	different	ADJ
admet-850	203	30	oral	oral	ADJ
admet-850	203	31	doses	dose	NOUN
admet-850	203	32	,	,	PUNCT
admet-850	203	33	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	PUNCT
admet-850	203	34	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	VERB
admet-850	203	35	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	203	36	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/trs1003_annex6.pdf?ua=1	NOUN
admet-850	204	1	valeria	valeria	PROPN
admet-850	204	2	gigante	gigante	PROPN
admet-850	204	3	et	et	PROPN
admet-850	204	4	al	al	PROPN
admet-850	204	5	.	.	PROPN
admet-850	204	6	admet	admet	PROPN
admet-850	204	7	&	&	CCONJ
admet-850	204	8	dmpk	dmpk	PROPN
admet-850	204	9	9(1	9(1	NUM
admet-850	204	10	)	)	PUNCT
admet-850	204	11	(	(	PUNCT
admet-850	204	12	2021	2021	NUM
admet-850	204	13	)	)	PUNCT
admet-850	204	14	23	23	NUM
admet-850	204	15	-	-	SYM
admet-850	204	16	39	39	NUM
admet-850	204	17	36	36	NUM
admet-850	204	18	made	make	VERB
admet-850	204	19	it	it	PRON
admet-850	204	20	feasible	feasible	ADJ
admet-850	204	21	to	to	PART
admet-850	204	22	define	define	VERB
admet-850	204	23	with	with	ADP
admet-850	204	24	high	high	ADJ
admet-850	204	25	confidence	confidence	NOUN
admet-850	204	26	permeability	permeability	NOUN
admet-850	204	27	for	for	ADP
admet-850	204	28	darunavir	darunavir	PROPN
admet-850	204	29	and	and	CCONJ
admet-850	204	30	tenofovir	tenofovir	PROPN
admet-850	204	31	disoproxil	disoproxil	PROPN
admet-850	204	32	,	,	PUNCT
admet-850	204	33	which	which	PRON
admet-850	204	34	were	be	AUX
admet-850	204	35	not	not	PART
admet-850	204	36	considered	consider	VERB
admet-850	204	37	during	during	ADP
admet-850	204	38	the	the	DET
admet-850	204	39	previous	previous	ADJ
admet-850	204	40	who	who	PRON
admet-850	204	41	bcs	bc	VERB
admet-850	204	42	assignment	assignment	NOUN
admet-850	204	43	in	in	ADP
admet-850	204	44	2006	2006	NUM
admet-850	204	45	.	.	PUNCT
admet-850	205	1	similarly	similarly	ADV
admet-850	205	2	,	,	PUNCT
admet-850	205	3	using	use	VERB
admet-850	205	4	the	the	DET
admet-850	205	5	same	same	ADJ
admet-850	205	6	consensus	consensus	NOUN
admet-850	205	7	approach	approach	NOUN
admet-850	205	8	that	that	PRON
admet-850	205	9	compares	compare	VERB
admet-850	205	10	the	the	PRON
admet-850	205	11	in	in	ADP
admet-850	205	12	silico	silico	NOUN
admet-850	205	13	predicted	predict	VERB
admet-850	205	14	fa	fa	PROPN
admet-850	205	15	in	in	ADP
admet-850	205	16	humans	human	NOUN
admet-850	205	17	and	and	CCONJ
admet-850	205	18	clinically	clinically	ADV
admet-850	205	19	determined	determine	VERB
admet-850	205	20	bioavailability	bioavailability	NOUN
admet-850	205	21	data	datum	NOUN
admet-850	205	22	for	for	ADP
admet-850	205	23	the	the	DET
admet-850	205	24	same	same	ADJ
admet-850	205	25	api	api	NOUN
admet-850	205	26	but	but	CCONJ
admet-850	205	27	measured	measure	VERB
admet-850	205	28	at	at	ADP
admet-850	205	29	different	different	ADJ
admet-850	205	30	doses	dose	NOUN
admet-850	205	31	,	,	PUNCT
admet-850	205	32	the	the	DET
admet-850	205	33	ambiguous	ambiguous	ADJ
admet-850	205	34	bcs	bcs	NOUN
admet-850	205	35	classification	classification	NOUN
admet-850	205	36	of	of	ADP
admet-850	205	37	azithromycin	azithromycin	PROPN
admet-850	205	38	,	,	PUNCT
admet-850	205	39	efavirenz	efavirenz	NOUN
admet-850	205	40	,	,	PUNCT
admet-850	205	41	and	and	CCONJ
admet-850	205	42	furosemide	furosemide	ADV
admet-850	205	43	were	be	AUX
admet-850	205	44	clarified	clarify	VERB
admet-850	205	45	.	.	PUNCT
admet-850	206	1	however	however	ADV
admet-850	206	2	,	,	PUNCT
admet-850	206	3	the	the	DET
admet-850	206	4	results	result	NOUN
admet-850	206	5	summarized	summarize	VERB
admet-850	206	6	in	in	ADP
admet-850	206	7	table	table	NOUN
admet-850	206	8	4	4	NUM
admet-850	206	9	clearly	clearly	ADV
admet-850	206	10	underline	underline	VERB
admet-850	206	11	significant	significant	ADJ
admet-850	206	12	discrepancies	discrepancy	NOUN
admet-850	206	13	between	between	ADP
admet-850	206	14	pbpk	pbpk	NOUN
admet-850	206	15	-	-	ADJ
admet-850	206	16	predicted	predict	VERB
admet-850	206	17	human	human	ADJ
admet-850	206	18	absorption	absorption	NOUN
admet-850	206	19	data	datum	NOUN
admet-850	206	20	and	and	CCONJ
admet-850	206	21	clinically	clinically	ADV
admet-850	206	22	measured	measure	VERB
admet-850	206	23	bioavailability	bioavailability	NOUN
admet-850	206	24	values	value	NOUN
admet-850	206	25	,	,	PUNCT
admet-850	206	26	specifically	specifically	ADV
admet-850	206	27	for	for	ADP
admet-850	206	28	codeine	codeine	NOUN
admet-850	206	29	,	,	PUNCT
admet-850	206	30	dolutegravir	dolutegravir	NOUN
admet-850	206	31	,	,	PUNCT
admet-850	206	32	ethionamide	ethionamide	NOUN
admet-850	206	33	,	,	PUNCT
admet-850	206	34	pyrimethamine	pyrimethamine	NOUN
admet-850	206	35	,	,	PUNCT
admet-850	206	36	raltegravir	raltegravir	PROPN
admet-850	206	37	,	,	PUNCT
admet-850	206	38	and	and	CCONJ
admet-850	206	39	rifampicin	rifampicin	VERB
admet-850	206	40	.	.	PUNCT
admet-850	207	1	for	for	ADP
admet-850	207	2	some	some	PRON
admet-850	207	3	of	of	ADP
admet-850	207	4	those	those	DET
admet-850	207	5	apis	apis	ADJ
admet-850	207	6	,	,	PUNCT
admet-850	207	7	such	such	ADJ
admet-850	207	8	as	as	ADP
admet-850	207	9	rifampicin	rifampicin	VERB
admet-850	207	10	,	,	PUNCT
admet-850	207	11	which	which	PRON
admet-850	207	12	has	have	AUX
admet-850	207	13	been	be	AUX
admet-850	207	14	described	describe	VERB
admet-850	207	15	to	to	PART
admet-850	207	16	experience	experience	VERB
admet-850	207	17	regiospecific	regiospecific	PROPN
admet-850	207	18	absorption	absorption	NOUN
admet-850	207	19	(	(	PUNCT
admet-850	207	20	jejunum	jejunum	NOUN
admet-850	207	21	>	>	X
admet-850	207	22	ileum	ileum	NOUN
admet-850	207	23	)	)	PUNCT
admet-850	207	24	due	due	ADP
admet-850	207	25	to	to	ADP
admet-850	207	26	significant	significant	ADJ
admet-850	207	27	affinity	affinity	NOUN
admet-850	207	28	for	for	ADP
admet-850	207	29	intestinal	intestinal	ADJ
admet-850	207	30	efflux	efflux	NOUN
admet-850	207	31	systems	system	NOUN
admet-850	207	32	such	such	ADJ
admet-850	207	33	as	as	ADP
admet-850	207	34	pglycoprotein	pglycoprotein	NOUN
admet-850	207	35	[	[	X
admet-850	207	36	21	21	NUM
admet-850	207	37	]	]	PUNCT
admet-850	207	38	,	,	PUNCT
admet-850	207	39	the	the	DET
admet-850	207	40	literature	literature	NOUN
admet-850	207	41	may	may	AUX
admet-850	207	42	provide	provide	VERB
admet-850	207	43	clues	clue	NOUN
admet-850	207	44	for	for	ADP
admet-850	207	45	a	a	DET
admet-850	207	46	reasonable	reasonable	ADJ
admet-850	207	47	scientific	scientific	ADJ
admet-850	207	48	hypothesis	hypothesis	NOUN
admet-850	207	49	that	that	PRON
admet-850	207	50	could	could	AUX
admet-850	207	51	explain	explain	VERB
admet-850	207	52	these	these	DET
admet-850	207	53	inconsistent	inconsistent	ADJ
admet-850	207	54	results	result	NOUN
admet-850	207	55	.	.	PUNCT
admet-850	208	1	for	for	ADP
admet-850	208	2	other	other	ADJ
admet-850	208	3	apis	apis	ADJ
admet-850	208	4	,	,	PUNCT
admet-850	208	5	scientific	scientific	ADJ
admet-850	208	6	explanations	explanation	NOUN
admet-850	208	7	are	be	AUX
admet-850	208	8	less	less	ADV
admet-850	208	9	clear	clear	ADJ
admet-850	208	10	and	and	CCONJ
admet-850	208	11	may	may	AUX
admet-850	208	12	require	require	VERB
admet-850	208	13	further	further	ADJ
admet-850	208	14	exploration	exploration	NOUN
admet-850	208	15	using	use	VERB
admet-850	208	16	carefully	carefully	ADV
admet-850	208	17	designed	design	VERB
admet-850	208	18	experimental	experimental	ADJ
admet-850	208	19	approaches	approach	NOUN
admet-850	208	20	to	to	PART
admet-850	208	21	assess	assess	VERB
admet-850	208	22	permeability	permeability	NOUN
admet-850	208	23	.	.	PUNCT
admet-850	209	1	it	it	PRON
admet-850	209	2	is	be	AUX
admet-850	209	3	generally	generally	ADV
admet-850	209	4	assumed	assume	VERB
admet-850	209	5	that	that	SCONJ
admet-850	209	6	physiologically	physiologically	ADV
admet-850	209	7	-	-	PUNCT
admet-850	209	8	based	base	VERB
admet-850	209	9	in	in	ADP
admet-850	209	10	silico	silico	NOUN
admet-850	209	11	absorption	absorption	NOUN
admet-850	209	12	models	model	NOUN
admet-850	209	13	are	be	AUX
admet-850	209	14	promising	promise	VERB
admet-850	209	15	supplemental	supplemental	ADJ
admet-850	209	16	tools	tool	NOUN
admet-850	209	17	to	to	PART
admet-850	209	18	traditional	traditional	VERB
admet-850	209	19	in	in	ADP
admet-850	209	20	vitro	vitro	X
admet-850	209	21	assays	assay	NOUN
admet-850	209	22	and	and	CCONJ
admet-850	209	23	preclinical	preclinical	ADJ
admet-850	209	24	in	in	ADP
admet-850	209	25	vivo	vivo	ADJ
admet-850	209	26	studies	study	NOUN
admet-850	209	27	.	.	PUNCT
admet-850	210	1	however	however	ADV
admet-850	210	2	,	,	PUNCT
admet-850	210	3	as	as	SCONJ
admet-850	210	4	recently	recently	ADV
admet-850	210	5	reported	report	VERB
admet-850	210	6	by	by	ADP
admet-850	210	7	sjögren	sjögren	PROPN
admet-850	210	8	and	and	CCONJ
admet-850	210	9	colleagues	colleague	NOUN
admet-850	210	10	[	[	X
admet-850	210	11	40	40	NUM
admet-850	210	12	]	]	PUNCT
admet-850	210	13	,	,	PUNCT
admet-850	210	14	different	different	ADJ
admet-850	210	15	modeling	modeling	NOUN
admet-850	210	16	platforms	platform	NOUN
admet-850	210	17	are	be	AUX
admet-850	210	18	associated	associate	VERB
admet-850	210	19	with	with	ADP
admet-850	210	20	inconsistent	inconsistent	ADJ
admet-850	210	21	overand	overand	PROPN
admet-850	210	22	under	under	NOUN
admet-850	210	23	-	-	PUNCT
admet-850	210	24	prediction	prediction	NOUN
admet-850	210	25	of	of	ADP
admet-850	210	26	the	the	DET
admet-850	210	27	fraction	fraction	NOUN
admet-850	210	28	absorbed	absorb	VERB
admet-850	210	29	.	.	PUNCT
admet-850	211	1	consequently	consequently	ADV
admet-850	211	2	,	,	PUNCT
admet-850	211	3	a	a	DET
admet-850	211	4	broader	broad	ADJ
admet-850	211	5	data	data	NOUN
admet-850	211	6	mining	mining	NOUN
admet-850	211	7	approach	approach	NOUN
admet-850	211	8	will	will	AUX
admet-850	211	9	be	be	AUX
admet-850	211	10	necessary	necessary	ADJ
admet-850	211	11	to	to	PART
admet-850	211	12	maximize	maximize	VERB
admet-850	211	13	confidence	confidence	NOUN
admet-850	211	14	in	in	ADP
admet-850	211	15	model	model	NOUN
admet-850	211	16	performance	performance	NOUN
admet-850	211	17	.	.	PUNCT
admet-850	212	1	conclusions	conclusion	NOUN
admet-850	212	2	the	the	DET
admet-850	212	3	results	result	NOUN
admet-850	212	4	from	from	ADP
admet-850	212	5	this	this	DET
admet-850	212	6	study	study	NOUN
admet-850	212	7	demonstrate	demonstrate	VERB
admet-850	212	8	successful	successful	ADJ
admet-850	212	9	validation	validation	NOUN
admet-850	212	10	of	of	ADP
admet-850	212	11	a	a	DET
admet-850	212	12	globally	globally	ADV
admet-850	212	13	harmonized	harmonize	VERB
admet-850	212	14	solubility	solubility	NOUN
admet-850	212	15	protocol	protocol	NOUN
admet-850	212	16	across	across	ADP
admet-850	212	17	different	different	ADJ
admet-850	212	18	international	international	ADJ
admet-850	212	19	laboratories	laboratory	NOUN
admet-850	212	20	to	to	PART
admet-850	212	21	support	support	VERB
admet-850	212	22	who	who	PRON
admet-850	212	23	bcs	bcs	VERB
admet-850	212	24	classification	classification	NOUN
admet-850	212	25	.	.	PUNCT
admet-850	213	1	implementation	implementation	NOUN
admet-850	213	2	of	of	ADP
admet-850	213	3	a	a	DET
admet-850	213	4	consensus	consensus	NOUN
admet-850	213	5	approach	approach	NOUN
admet-850	213	6	that	that	PRON
admet-850	213	7	compares	compare	VERB
admet-850	213	8	in	in	ADP
admet-850	213	9	silico	silico	NOUN
admet-850	213	10	predicted	predict	VERB
admet-850	213	11	fa	fa	INTJ
admet-850	213	12	in	in	ADP
admet-850	213	13	humans	human	NOUN
admet-850	213	14	using	use	VERB
admet-850	213	15	the	the	DET
admet-850	213	16	gastroplus	gastroplus	NOUN
admet-850	213	17	©	©	PROPN
admet-850	213	18	pbpk	pbpk	ADJ
admet-850	213	19	simulation	simulation	NOUN
admet-850	213	20	platform	platform	NOUN
admet-850	213	21	and	and	CCONJ
admet-850	213	22	clinically	clinically	ADV
admet-850	213	23	determined	determine	VERB
admet-850	213	24	bioavailability	bioavailability	NOUN
admet-850	213	25	data	datum	NOUN
admet-850	213	26	for	for	ADP
admet-850	213	27	the	the	DET
admet-850	213	28	same	same	ADJ
admet-850	213	29	api	api	NOUN
admet-850	213	30	but	but	CCONJ
admet-850	213	31	measured	measure	VERB
admet-850	213	32	at	at	ADP
admet-850	213	33	different	different	ADJ
admet-850	213	34	doses	dose	NOUN
admet-850	213	35	enabled	enable	VERB
admet-850	213	36	unambiguous	unambiguous	ADJ
admet-850	213	37	assignment	assignment	NOUN
admet-850	213	38	of	of	ADP
admet-850	213	39	10	10	NUM
admet-850	213	40	out	out	ADP
admet-850	213	41	of	of	ADP
admet-850	213	42	the	the	DET
admet-850	213	43	16	16	NUM
admet-850	213	44	apis	apis	NOUN
admet-850	213	45	selected	select	VERB
admet-850	213	46	for	for	ADP
admet-850	213	47	this	this	DET
admet-850	213	48	pilot	pilot	NOUN
admet-850	213	49	study	study	NOUN
admet-850	213	50	to	to	ADP
admet-850	213	51	one	one	NUM
admet-850	213	52	of	of	ADP
admet-850	213	53	the	the	DET
admet-850	213	54	four	four	NUM
admet-850	213	55	bcs	bcs	NOUN
admet-850	213	56	classes	class	NOUN
admet-850	213	57	.	.	PUNCT
admet-850	214	1	further	further	ADJ
admet-850	214	2	expansion	expansion	NOUN
admet-850	214	3	of	of	ADP
admet-850	214	4	these	these	DET
admet-850	214	5	experimental	experimental	ADJ
admet-850	214	6	efforts	effort	NOUN
admet-850	214	7	to	to	ADP
admet-850	214	8	qualified	qualified	ADJ
admet-850	214	9	apis	apis	PROPN
admet-850	214	10	from	from	ADP
admet-850	214	11	the	the	PRON
admet-850	214	12	who	who	PRON
admet-850	214	13	essential	essential	ADJ
admet-850	214	14	medicines	medicine	NOUN
admet-850	214	15	list	list	NOUN
admet-850	214	16	is	be	AUX
admet-850	214	17	predicted	predict	VERB
admet-850	214	18	to	to	PART
admet-850	214	19	provide	provide	VERB
admet-850	214	20	regulatory	regulatory	ADJ
admet-850	214	21	authorities	authority	NOUN
admet-850	214	22	across	across	ADP
admet-850	214	23	the	the	DET
admet-850	214	24	globe	globe	NOUN
admet-850	214	25	with	with	ADP
admet-850	214	26	scientifically	scientifically	ADV
admet-850	214	27	validated	validate	VERB
admet-850	214	28	data	datum	NOUN
admet-850	214	29	to	to	PART
admet-850	214	30	support	support	VERB
admet-850	214	31	decisions	decision	NOUN
admet-850	214	32	regarding	regard	VERB
admet-850	214	33	the	the	DET
admet-850	214	34	need	need	NOUN
admet-850	214	35	for	for	ADP
admet-850	214	36	in	in	ADP
admet-850	214	37	vivo	vivo	ADJ
admet-850	214	38	bioequivalence	bioequivalence	NOUN
admet-850	214	39	studies	study	NOUN
admet-850	214	40	.	.	PUNCT
admet-850	215	1	ultimately	ultimately	ADV
admet-850	215	2	,	,	PUNCT
admet-850	215	3	this	this	PRON
admet-850	215	4	will	will	AUX
admet-850	215	5	improve	improve	VERB
admet-850	215	6	access	access	NOUN
admet-850	215	7	to	to	ADP
admet-850	215	8	affordable	affordable	ADJ
admet-850	215	9	generic	generic	ADJ
admet-850	215	10	products	product	NOUN
admet-850	215	11	,	,	PUNCT
admet-850	215	12	which	which	PRON
admet-850	215	13	is	be	AUX
admet-850	215	14	a	a	DET
admet-850	215	15	critical	critical	ADJ
admet-850	215	16	prerequisite	prerequisite	NOUN
admet-850	215	17	to	to	PART
admet-850	215	18	reach	reach	VERB
admet-850	215	19	universal	universal	ADJ
admet-850	215	20	health	health	NOUN
admet-850	215	21	coverage	coverage	NOUN
admet-850	215	22	.	.	PUNCT
admet-850	216	1	acknowledgements	acknowledgement	NOUN
admet-850	216	2	equilibrium	equilibrium	NOUN
admet-850	216	3	solubility	solubility	NOUN
admet-850	216	4	experiments	experiment	NOUN
admet-850	216	5	were	be	AUX
admet-850	216	6	conducted	conduct	VERB
admet-850	216	7	by	by	ADP
admet-850	216	8	universities	university	NOUN
admet-850	216	9	,	,	PUNCT
admet-850	216	10	official	official	ADJ
admet-850	216	11	national	national	ADJ
admet-850	216	12	control	control	PROPN
admet-850	216	13	laboratories	laboratory	NOUN
admet-850	216	14	,	,	PUNCT
admet-850	216	15	pharmacopoeia	pharmacopoeia	NOUN
admet-850	216	16	laboratory	laboratory	NOUN
admet-850	216	17	,	,	PUNCT
admet-850	216	18	and	and	CCONJ
admet-850	216	19	who	who	PRON
admet-850	216	20	collaborating	collaborate	VERB
admet-850	216	21	centres	centre	NOUN
admet-850	216	22	.	.	PUNCT
admet-850	217	1	the	the	DET
admet-850	217	2	authors	author	NOUN
admet-850	217	3	warmly	warmly	ADV
admet-850	217	4	thank	thank	VERB
admet-850	217	5	:	:	PUNCT
admet-850	217	6	liezl	liezl	PROPN
admet-850	217	7	badenhorst	badenhorst	PROPN
admet-850	217	8	,	,	PUNCT
admet-850	217	9	north_west	north_w	ADJ
admet-850	217	10	university	university	NOUN
admet-850	217	11	,	,	PUNCT
admet-850	217	12	potchefstroom	potchefstroom	NOUN
admet-850	217	13	,	,	PUNCT
admet-850	217	14	south	south	PROPN
admet-850	217	15	africa	africa	PROPN
admet-850	217	16	;	;	PUNCT
admet-850	217	17	jeronimo	jeronimo	PROPN
admet-850	217	18	r.	r.	PROPN
admet-850	217	19	de	de	PROPN
admet-850	217	20	oliveira	oliveira	PROPN
admet-850	217	21	neto	neto	PROPN
admet-850	217	22	,	,	PUNCT
admet-850	217	23	faculty	faculty	NOUN
admet-850	217	24	of	of	ADP
admet-850	217	25	pharmacy	pharmacy	NOUN
admet-850	217	26	,	,	PUNCT
admet-850	217	27	federal	federal	ADJ
admet-850	217	28	university	university	PROPN
admet-850	217	29	of	of	ADP
admet-850	217	30	goiás	goiás	NOUN
admet-850	217	31	,	,	PUNCT
admet-850	217	32	goiânia	goiânia	PROPN
admet-850	217	33	,	,	PUNCT
admet-850	217	34	goiás	goiás	NOUN
admet-850	217	35	,	,	PUNCT
admet-850	217	36	brazil	brazil	PROPN
admet-850	217	37	;	;	PUNCT
admet-850	217	38	elena	elena	PROPN
admet-850	217	39	soler	soler	PROPN
admet-850	217	40	,	,	PUNCT
admet-850	217	41	universidad	universidad	PROPN
admet-850	217	42	miguel	miguel	PROPN
admet-850	217	43	hernández	hernández	PROPN
admet-850	217	44	de	de	PROPN
admet-850	217	45	elche	elche	PROPN
admet-850	217	46	,	,	PUNCT
admet-850	217	47	alicante	alicante	PROPN
admet-850	217	48	,	,	PUNCT
admet-850	217	49	spain	spain	PROPN
admet-850	217	50	;	;	PUNCT
admet-850	217	51	matilde	matilde	PROPN
admet-850	217	52	merino	merino	NOUN
admet-850	217	53	-	-	PUNCT
admet-850	217	54	sanjuán	sanjuán	NOUN
admet-850	217	55	,	,	PUNCT
admet-850	217	56	university	university	NOUN
admet-850	217	57	of	of	ADP
admet-850	217	58	valencia	valencia	PROPN
admet-850	217	59	,	,	PUNCT
admet-850	217	60	valencia	valencia	PROPN
admet-850	217	61	,	,	PUNCT
admet-850	217	62	spain	spain	PROPN
admet-850	217	63	;	;	PUNCT
admet-850	217	64	nilesh	nilesh	PROPN
admet-850	217	65	m.	m.	PROPN
admet-850	217	66	meghani	meghani	PROPN
admet-850	217	67	,	,	PUNCT
admet-850	217	68	college	college	NOUN
admet-850	217	69	of	of	ADP
admet-850	217	70	pharmacy	pharmacy	NOUN
admet-850	217	71	and	and	CCONJ
admet-850	217	72	institute	institute	NOUN
admet-850	217	73	of	of	ADP
admet-850	217	74	pharmaceutical	pharmaceutical	NOUN
admet-850	217	75	science	science	NOUN
admet-850	217	76	and	and	CCONJ
admet-850	217	77	technology	technology	NOUN
admet-850	217	78	,	,	PUNCT
admet-850	217	79	ajou	ajou	VERB
admet-850	217	80	university	university	NOUN
admet-850	217	81	,	,	PUNCT
admet-850	217	82	suwon	suwon	PROPN
admet-850	217	83	,	,	PUNCT
admet-850	217	84	republic	republic	NOUN
admet-850	217	85	of	of	ADP
admet-850	217	86	korea	korea	PROPN
admet-850	217	87	;	;	PUNCT
admet-850	217	88	tri	tri	ADJ
admet-850	217	89	-	-	ADJ
admet-850	217	90	hung	hung	ADJ
admet-850	217	91	nguyen	nguyen	NOUN
admet-850	217	92	,	,	PUNCT
admet-850	217	93	medicines	medicine	NOUN
admet-850	217	94	manufacturing	manufacturing	NOUN
admet-850	217	95	innovation	innovation	NOUN
admet-850	217	96	centre	centre	NOUN
admet-850	217	97	,	,	PUNCT
admet-850	217	98	monash	monash	PROPN
admet-850	217	99	institute	institute	PROPN
admet-850	217	100	of	of	ADP
admet-850	217	101	pharmaceutical	pharmaceutical	PROPN
admet-850	217	102	sciences	sciences	PROPN
admet-850	217	103	,	,	PUNCT
admet-850	217	104	monash	monash	PROPN
admet-850	217	105	university	university	PROPN
admet-850	217	106	,	,	PUNCT
admet-850	217	107	parkville	parkville	PROPN
admet-850	217	108	,	,	PUNCT
admet-850	217	109	australia	australia	PROPN
admet-850	217	110	;	;	PUNCT
admet-850	217	111	raju	raju	PROPN
admet-850	217	112	kanumuri	kanumuri	PROPN
admet-850	217	113	,	,	PUNCT
admet-850	217	114	university	university	PROPN
admet-850	217	115	of	of	ADP
admet-850	217	116	cincinnati	cincinnati	PROPN
admet-850	217	117	,	,	PUNCT
admet-850	217	118	cincinnati	cincinnati	PROPN
admet-850	217	119	,	,	PUNCT
admet-850	217	120	ohio	ohio	PROPN
admet-850	217	121	,	,	PUNCT
admet-850	217	122	usa	usa	PROPN
admet-850	217	123	;	;	PUNCT
admet-850	217	124	satish	satish	PROPN
admet-850	217	125	agrawal	agrawal	PROPN
admet-850	217	126	,	,	PUNCT
admet-850	217	127	st	st	PROPN
admet-850	217	128	.	.	PROPN
admet-850	217	129	louis	louis	PROPN
admet-850	217	130	college	college	PROPN
admet-850	217	131	of	of	ADP
admet-850	217	132	pharmacy	pharmacy	PROPN
admet-850	217	133	,	,	PUNCT
admet-850	217	134	st	st	PROPN
admet-850	217	135	,	,	PUNCT
admet-850	217	136	louis	louis	PROPN
admet-850	217	137	,	,	PUNCT
admet-850	217	138	missouri	missouri	PROPN
admet-850	217	139	,	,	PUNCT
admet-850	217	140	usa	usa	PROPN
admet-850	217	141	;	;	PUNCT
admet-850	217	142	jing	jing	PROPN
admet-850	217	143	xiong	xiong	PROPN
admet-850	217	144	,	,	PUNCT
admet-850	217	145	national	national	PROPN
admet-850	217	146	institutes	institute	NOUN
admet-850	217	147	for	for	ADP
admet-850	217	148	food	food	NOUN
admet-850	217	149	and	and	CCONJ
admet-850	217	150	drug	drug	NOUN
admet-850	217	151	control	control	NOUN
admet-850	217	152	(	(	PUNCT
admet-850	217	153	nifdc	nifdc	ADJ
admet-850	217	154	)	)	PUNCT
admet-850	217	155	,	,	PUNCT
admet-850	217	156	beijing	beijing	PROPN
admet-850	217	157	,	,	PUNCT
admet-850	217	158	china	china	PROPN
admet-850	217	159	;	;	PUNCT
admet-850	217	160	ramesh	ramesh	PROPN
admet-850	217	161	kumar	kumar	PROPN
admet-850	217	162	jha	jha	PROPN
admet-850	217	163	,	,	PUNCT
admet-850	217	164	indian	indian	PROPN
admet-850	217	165	pharmacopoeia	pharmacopoeia	PROPN
admet-850	217	166	commission	commission	PROPN
admet-850	217	167	,	,	PUNCT
admet-850	217	168	ministry	ministry	PROPN
admet-850	217	169	of	of	ADP
admet-850	217	170	health	health	PROPN
admet-850	217	171	&	&	CCONJ
admet-850	217	172	family	family	PROPN
admet-850	217	173	welfare	welfare	NOUN
admet-850	217	174	,	,	PUNCT
admet-850	217	175	govt	govt	NOUN
admet-850	217	176	.	.	PUNCT
admet-850	218	1	of	of	ADP
admet-850	218	2	india	india	PROPN
admet-850	218	3	,	,	PUNCT
admet-850	218	4	ghaziabad	ghaziabad	PROPN
admet-850	218	5	,	,	PUNCT
admet-850	218	6	india	india	PROPN
admet-850	218	7	;	;	PUNCT
admet-850	218	8	for	for	ADP
admet-850	218	9	the	the	DET
admet-850	218	10	precious	precious	ADJ
admet-850	218	11	collaboration	collaboration	NOUN
admet-850	218	12	in	in	ADP
admet-850	218	13	producing	produce	VERB
admet-850	218	14	experimental	experimental	ADJ
admet-850	218	15	data	datum	NOUN
admet-850	218	16	.	.	PUNCT
admet-850	219	1	all	all	DET
admet-850	219	2	apis	apis	PROPN
admet-850	219	3	studied	study	VERB
admet-850	219	4	in	in	ADP
admet-850	219	5	cycles	cycle	NOUN
admet-850	219	6	i	i	PRON
admet-850	219	7	and	and	CCONJ
admet-850	219	8	ii	ii	PROPN
admet-850	219	9	were	be	AUX
admet-850	219	10	received	receive	VERB
admet-850	219	11	as	as	ADP
admet-850	219	12	in	in	ADP
admet-850	219	13	-	-	PUNCT
admet-850	219	14	kind	kind	NOUN
admet-850	219	15	donations	donation	NOUN
admet-850	219	16	from	from	ADP
admet-850	219	17	pharmaceutical	pharmaceutical	ADJ
admet-850	219	18	manufacturers	manufacturer	NOUN
admet-850	219	19	admet	admet	PROPN
admet-850	219	20	&	&	CCONJ
admet-850	219	21	dmpk	dmpk	PROPN
admet-850	219	22	9(1	9(1	NUM
admet-850	219	23	)	)	PUNCT
admet-850	219	24	(	(	PUNCT
admet-850	219	25	2021	2021	NUM
admet-850	219	26	)	)	PUNCT
admet-850	219	27	23	23	NUM
admet-850	219	28	-	-	SYM
admet-850	219	29	39	39	NUM
admet-850	219	30	enhancing	enhance	VERB
admet-850	219	31	robustness	robustness	NOUN
admet-850	219	32	of	of	ADP
admet-850	219	33	the	the	PRON
admet-850	219	34	who	who	PRON
admet-850	219	35	biopharmaceutical	biopharmaceutical	ADJ
admet-850	219	36	classification	classification	NOUN
admet-850	219	37	system	system	NOUN
admet-850	219	38	doi	doi	NOUN
admet-850	219	39	:	:	PUNCT
admet-850	219	40	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	NOUN
admet-850	219	41	37	37	NUM
admet-850	219	42	supporting	support	VERB
admet-850	219	43	who	who	PRON
admet-850	219	44	in	in	ADP
admet-850	219	45	this	this	DET
admet-850	219	46	scientific	scientific	ADJ
admet-850	219	47	work	work	NOUN
admet-850	219	48	:	:	PUNCT
admet-850	219	49	acs	acs	PROPN
admet-850	219	50	dobfar	dobfar	PROPN
admet-850	219	51	;	;	PUNCT
admet-850	219	52	alcaliber	alcaliber	ADJ
admet-850	219	53	s.a.u	s.a.u	NOUN
admet-850	219	54	.	.	PUNCT
admet-850	219	55	;	;	PUNCT
admet-850	219	56	aurobindo	aurobindo	PROPN
admet-850	219	57	;	;	PUNCT
admet-850	219	58	cipla	cipla	PROPN
admet-850	219	59	ltd	ltd	PROPN
admet-850	219	60	;	;	PUNCT
admet-850	219	61	guilin	guilin	PROPN
admet-850	219	62	pharmaceutical	pharmaceutical	PROPN
admet-850	219	63	co.	co.	PROPN
admet-850	219	64	ltd	ltd	PROPN
admet-850	219	65	;	;	PUNCT
admet-850	219	66	ipca	ipca	PROPN
admet-850	219	67	laboratories	laboratories	PROPN
admet-850	219	68	ltd	ltd	PROPN
admet-850	219	69	;	;	PUNCT
admet-850	219	70	laurus	laurus	PROPN
admet-850	219	71	labs	labs	PROPN
admet-850	219	72	limited	limit	VERB
admet-850	219	73	;	;	PUNCT
admet-850	219	74	lupin	lupin	PROPN
admet-850	219	75	ltd	ltd	PROPN
admet-850	219	76	.	.	PROPN
admet-850	219	77	;	;	PUNCT
admet-850	219	78	macleods	macleod	NOUN
admet-850	219	79	pharmaceuticals	pharmaceuticals	PROPN
admet-850	219	80	ltd	ltd	PROPN
admet-850	219	81	;	;	PUNCT
admet-850	219	82	mangalam	mangalam	PROPN
admet-850	219	83	drugs	drugs	PROPN
admet-850	219	84	&	&	CCONJ
admet-850	219	85	organics	organics	PROPN
admet-850	219	86	ltd	ltd	PROPN
admet-850	219	87	;	;	PUNCT
admet-850	219	88	mylan	mylan	PROPN
admet-850	219	89	laboratories	laboratories	PROPN
admet-850	219	90	ltd	ltd	PROPN
admet-850	219	91	;	;	PUNCT
admet-850	219	92	sandoz	sandoz	PROPN
admet-850	219	93	;	;	PUNCT
admet-850	219	94	sanofi	sanofi	PROPN
admet-850	219	95	;	;	PUNCT
admet-850	219	96	shanghai	shanghai	PROPN
admet-850	219	97	desano	desano	PROPN
admet-850	219	98	chemical	chemical	PROPN
admet-850	219	99	pharmaceutical	pharmaceutical	PROPN
admet-850	219	100	co.	co.	PROPN
admet-850	219	101	ltd	ltd	PROPN
admet-850	219	102	;	;	PUNCT
admet-850	219	103	shenyang	shenyang	PROPN
admet-850	219	104	antibiotic	antibiotic	PROPN
admet-850	219	105	;	;	PUNCT
admet-850	219	106	pfizer	pfizer	NOUN
admet-850	219	107	;	;	PUNCT
admet-850	219	108	zhejiang	zhejiang	PROPN
admet-850	219	109	jiangbei	jiangbei	PROPN
admet-850	219	110	pharmaceutical	pharmaceutical	PROPN
admet-850	219	111	co.	co.	PROPN
admet-850	219	112	ltd	ltd	PROPN
admet-850	219	113	.	.	PROPN
admet-850	219	114	conflict	conflict	NOUN
admet-850	219	115	of	of	ADP
admet-850	219	116	interest	interest	NOUN
admet-850	219	117	:	:	PUNCT
admet-850	219	118	the	the	DET
admet-850	219	119	authors	author	NOUN
admet-850	219	120	report	report	VERB
admet-850	219	121	no	no	DET
admet-850	219	122	conflict	conflict	NOUN
admet-850	219	123	of	of	ADP
admet-850	219	124	interest	interest	NOUN
admet-850	219	125	.	.	PUNCT
admet-850	220	1	disclaimer	disclaimer	ADJ
admet-850	220	2	:	:	PUNCT
admet-850	220	3	this	this	DET
admet-850	220	4	manuscript	manuscript	NOUN
admet-850	220	5	represents	represent	VERB
admet-850	220	6	the	the	DET
admet-850	220	7	personal	personal	ADJ
admet-850	220	8	opinion	opinion	NOUN
admet-850	220	9	of	of	ADP
admet-850	220	10	the	the	DET
admet-850	220	11	authors	author	NOUN
admet-850	220	12	and	and	CCONJ
admet-850	220	13	does	do	AUX
admet-850	220	14	not	not	PART
admet-850	220	15	necessarily	necessarily	ADV
admet-850	220	16	represent	represent	VERB
admet-850	220	17	the	the	DET
admet-850	220	18	views	view	NOUN
admet-850	220	19	or	or	CCONJ
admet-850	220	20	policy	policy	NOUN
admet-850	220	21	of	of	ADP
admet-850	220	22	their	their	PRON
admet-850	220	23	corresponding	correspond	VERB
admet-850	220	24	institutions	institution	NOUN
admet-850	220	25	.	.	PUNCT
admet-850	221	1	references	reference	NOUN
admet-850	221	2	[	[	X
admet-850	221	3	1	1	NUM
admet-850	221	4	]	]	PUNCT
admet-850	221	5	world	world	PROPN
admet-850	221	6	health	health	NOUN
admet-850	221	7	organization	organization	NOUN
admet-850	221	8	,	,	PUNCT
admet-850	221	9	access	access	NOUN
admet-850	221	10	to	to	ADP
admet-850	221	11	medicines	medicine	NOUN
admet-850	221	12	:	:	PUNCT
admet-850	221	13	making	make	VERB
admet-850	221	14	market	market	NOUN
admet-850	221	15	forces	force	NOUN
admet-850	221	16	serve	serve	VERB
admet-850	221	17	the	the	DET
admet-850	221	18	poor	poor	ADJ
admet-850	221	19	.	.	PUNCT
admet-850	222	1	ten	ten	NUM
admet-850	222	2	years	year	NOUN
admet-850	222	3	in	in	ADP
admet-850	222	4	public	public	ADJ
admet-850	222	5	health	health	NOUN
admet-850	222	6	2007–2017	2007–2017	NUM
admet-850	222	7	.	.	PUNCT
admet-850	222	8	,	,	PUNCT
admet-850	222	9	(	(	PUNCT
admet-850	222	10	2017	2017	NUM
admet-850	222	11	)	)	PUNCT
admet-850	222	12	.	.	PUNCT
admet-850	223	1	https://www.who.int/publications/10-year-review/en/	https://www.who.int/publications/10-year-review/en/	NOUN
admet-850	223	2	(	(	PUNCT
admet-850	223	3	accessed	access	VERB
admet-850	223	4	may	may	PROPN
admet-850	223	5	6	6	NUM
admet-850	223	6	,	,	PUNCT
admet-850	223	7	2020	2020	NUM
admet-850	223	8	)	)	PUNCT
admet-850	223	9	.	.	PUNCT
admet-850	224	1	[	[	X
admet-850	224	2	2	2	X
admet-850	224	3	]	]	PUNCT
admet-850	224	4	the	the	DET
admet-850	224	5	world	world	NOUN
admet-850	224	6	medicines	medicine	NOUN
admet-850	224	7	situation	situation	NOUN
admet-850	224	8	:	:	PUNCT
admet-850	224	9	chapter	chapter	NOUN
admet-850	224	10	7	7	NUM
admet-850	224	11	.	.	PUNCT
admet-850	224	12	access	access	NOUN
admet-850	224	13	to	to	ADP
admet-850	224	14	essential	essential	ADJ
admet-850	224	15	medicines	medicine	NOUN
admet-850	224	16	,	,	PUNCT
admet-850	224	17	(	(	PUNCT
admet-850	224	18	1999	1999	NUM
admet-850	224	19	)	)	PUNCT
admet-850	224	20	.	.	PUNCT
admet-850	225	1	http://digicollection.org/hss/en/d/js6160e/9.html	http://digicollection.org/hss/en/d/js6160e/9.html	PROPN
admet-850	225	2	(	(	PUNCT
admet-850	225	3	accessed	access	VERB
admet-850	225	4	may	may	PROPN
admet-850	225	5	6	6	NUM
admet-850	225	6	,	,	PUNCT
admet-850	225	7	2020	2020	NUM
admet-850	225	8	)	)	PUNCT
admet-850	225	9	.	.	PUNCT
admet-850	226	1	[	[	X
admet-850	226	2	3	3	X
admet-850	226	3	]	]	X
admet-850	226	4	g.l	g.l	PROPN
admet-850	226	5	.	.	PROPN
admet-850	226	6	amidon	amidon	PROPN
admet-850	226	7	,	,	PUNCT
admet-850	226	8	h.	h.	PROPN
admet-850	226	9	lennernäs	lennernäs	PROPN
admet-850	226	10	,	,	PUNCT
admet-850	226	11	v.p	v.p	PROPN
admet-850	226	12	.	.	PROPN
admet-850	226	13	shah	shah	PROPN
admet-850	226	14	,	,	PUNCT
admet-850	226	15	and	and	CCONJ
admet-850	226	16	j.r	j.r	PROPN
admet-850	226	17	.	.	PROPN
admet-850	226	18	crison	crison	PROPN
admet-850	226	19	,	,	PUNCT
admet-850	226	20	a	a	DET
admet-850	226	21	theoretical	theoretical	ADJ
admet-850	226	22	basis	basis	NOUN
admet-850	226	23	for	for	ADP
admet-850	226	24	a	a	DET
admet-850	226	25	biopharmaceutic	biopharmaceutic	ADJ
admet-850	226	26	drug	drug	NOUN
admet-850	226	27	classification	classification	NOUN
admet-850	226	28	:	:	PUNCT
admet-850	226	29	the	the	DET
admet-850	226	30	correlation	correlation	NOUN
admet-850	226	31	of	of	ADP
admet-850	226	32	in	in	ADP
admet-850	226	33	vitro	vitro	X
admet-850	226	34	drug	drug	NOUN
admet-850	226	35	product	product	NOUN
admet-850	226	36	dissolution	dissolution	NOUN
admet-850	226	37	and	and	CCONJ
admet-850	226	38	in	in	ADP
admet-850	226	39	vivo	vivo	ADJ
admet-850	226	40	bioavailability	bioavailability	NOUN
admet-850	226	41	,	,	PUNCT
admet-850	226	42	pharm	pharm	NOUN
admet-850	226	43	.	.	PUNCT
admet-850	227	1	res	re	NOUN
admet-850	227	2	.	.	PUNCT
admet-850	228	1	an	an	DET
admet-850	228	2	off	off	NOUN
admet-850	228	3	.	.	PUNCT
admet-850	229	1	j.	j.	PROPN
admet-850	229	2	am	am	PROPN
admet-850	229	3	.	.	PUNCT
admet-850	230	1	assoc	assoc	PROPN
admet-850	230	2	.	.	PUNCT
admet-850	231	1	pharm	pharm	PROPN
admet-850	231	2	.	.	PUNCT
admet-850	232	1	sci	sci	PROPN
admet-850	232	2	.	.	PROPN
admet-850	233	1	12	12	NUM
admet-850	233	2	(	(	PUNCT
admet-850	233	3	1995	1995	NUM
admet-850	233	4	)	)	PUNCT
admet-850	234	1	413–420	413–420	NUM
admet-850	234	2	.	.	PUNCT
admet-850	235	1	doi	doi	NOUN
admet-850	235	2	:	:	PUNCT
admet-850	235	3	https://doi.org/10.1023/a:1016212804288	https://doi.org/10.1023/a:1016212804288	PROPN
admet-850	235	4	.	.	PUNCT
admet-850	236	1	[	[	X
admet-850	236	2	4	4	X
admet-850	236	3	]	]	PUNCT
admet-850	236	4	world	world	NOUN
admet-850	236	5	health	health	NOUN
admet-850	236	6	organization	organization	NOUN
admet-850	236	7	,	,	PUNCT
admet-850	236	8	the	the	DET
admet-850	236	9	selection	selection	NOUN
admet-850	236	10	and	and	CCONJ
admet-850	236	11	use	use	NOUN
admet-850	236	12	of	of	ADP
admet-850	236	13	essential	essential	ADJ
admet-850	236	14	medicines	medicine	NOUN
admet-850	236	15	the	the	DET
admet-850	236	16	selection	selection	NOUN
admet-850	236	17	and	and	CCONJ
admet-850	236	18	use	use	NOUN
admet-850	236	19	of	of	ADP
admet-850	236	20	essential	essential	ADJ
admet-850	236	21	medicines	medicine	NOUN
admet-850	236	22	who	who	PRON
admet-850	236	23	technical	technical	ADJ
admet-850	236	24	report	report	NOUN
admet-850	236	25	series	series	PROPN
admet-850	236	26	,	,	PUNCT
admet-850	236	27	geneva	geneva	PROPN
admet-850	236	28	,	,	PUNCT
admet-850	236	29	2019	2019	NUM
admet-850	236	30	.	.	PUNCT
admet-850	237	1	http://www.who.int/	http://www.who.int/	NOUN
admet-850	237	2	(	(	PUNCT
admet-850	237	3	accessed	access	VERB
admet-850	237	4	may	may	PROPN
admet-850	237	5	6	6	NUM
admet-850	237	6	,	,	PUNCT
admet-850	237	7	2020	2020	NUM
admet-850	237	8	)	)	PUNCT
admet-850	237	9	.	.	PUNCT
admet-850	238	1	[	[	X
admet-850	238	2	5	5	X
admet-850	238	3	]	]	PUNCT
admet-850	238	4	world	world	PROPN
admet-850	238	5	health	health	NOUN
admet-850	238	6	organization	organization	NOUN
admet-850	238	7	,	,	PUNCT
admet-850	238	8	multisource	multisource	PROPN
admet-850	238	9	(	(	PUNCT
admet-850	238	10	generic	generic	ADJ
admet-850	238	11	)	)	PUNCT
admet-850	238	12	pharmaceutical	pharmaceutical	NOUN
admet-850	238	13	products	product	NOUN
admet-850	238	14	:	:	PUNCT
admet-850	238	15	guidelines	guideline	NOUN
admet-850	238	16	on	on	ADP
admet-850	238	17	registration	registration	NOUN
admet-850	238	18	requirements	requirement	NOUN
admet-850	238	19	to	to	PART
admet-850	238	20	establish	establish	VERB
admet-850	238	21	interchangeability	interchangeability	NOUN
admet-850	238	22	,	,	PUNCT
admet-850	238	23	in	in	ADP
admet-850	238	24	:	:	PUNCT
admet-850	238	25	who	who	PRON
admet-850	238	26	expert	expert	VERB
admet-850	238	27	comm	comm	NOUN
admet-850	238	28	.	.	PUNCT
admet-850	239	1	specif	specif	PROPN
admet-850	239	2	.	.	PUNCT
admet-850	240	1	pharm	pharm	PROPN
admet-850	240	2	.	.	PUNCT
admet-850	241	1	prep	prep	PROPN
admet-850	241	2	.	.	PROPN
admet-850	241	3	,	,	PUNCT
admet-850	241	4	geneva	geneva	PROPN
admet-850	241	5	,	,	PUNCT
admet-850	241	6	2017	2017	NUM
admet-850	241	7	.	.	PUNCT
admet-850	242	1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/expert_committee/who_t	https://www.who.int/medicines/areas/quality_safety/quality_assurance/expert_committee/who_t	NOUN
admet-850	242	2	rs_1003_full-version.pdf?ua=1	rs_1003_full-version.pdf?ua=1	NOUN
admet-850	242	3	(	(	PUNCT
admet-850	242	4	accessed	access	VERB
admet-850	242	5	may	may	PROPN
admet-850	242	6	6	6	NUM
admet-850	242	7	,	,	PUNCT
admet-850	242	8	2020	2020	NUM
admet-850	242	9	)	)	PUNCT
admet-850	242	10	.	.	PUNCT
admet-850	243	1	[	[	X
admet-850	243	2	6	6	NUM
admet-850	243	3	]	]	PUNCT
admet-850	243	4	world	world	NOUN
admet-850	243	5	health	health	NOUN
admet-850	243	6	organization	organization	NOUN
admet-850	243	7	,	,	PUNCT
admet-850	243	8	proposal	proposal	NOUN
admet-850	243	9	to	to	PART
admet-850	243	10	waive	waive	VERB
admet-850	243	11	in	in	ADP
admet-850	243	12	vivo	vivo	ADJ
admet-850	243	13	bioequivalence	bioequivalence	NOUN
admet-850	243	14	requirements	requirement	NOUN
admet-850	243	15	for	for	ADP
admet-850	243	16	who	who	PRON
admet-850	243	17	model	model	NOUN
admet-850	243	18	list	list	NOUN
admet-850	243	19	of	of	ADP
admet-850	243	20	essential	essential	ADJ
admet-850	243	21	medicines	medicine	NOUN
admet-850	243	22	immediate	immediate	ADJ
admet-850	243	23	-	-	PUNCT
admet-850	243	24	release	release	NOUN
admet-850	243	25	,	,	PUNCT
admet-850	243	26	solid	solid	ADJ
admet-850	243	27	oral	oral	ADJ
admet-850	243	28	dosage	dosage	NOUN
admet-850	243	29	forms	form	NOUN
admet-850	243	30	,	,	PUNCT
admet-850	243	31	2006	2006	NUM
admet-850	243	32	.	.	PUNCT
admet-850	244	1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequi	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequi	NOUN
admet-850	244	2	valencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937a	valencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937a	NOUN
admet-850	244	3	nnex8.pdf?ua=1	nnex8.pdf?ua=1	NOUN
admet-850	244	4	(	(	PUNCT
admet-850	244	5	accessed	access	VERB
admet-850	244	6	may	may	PROPN
admet-850	244	7	6	6	NUM
admet-850	244	8	,	,	PUNCT
admet-850	244	9	2020	2020	NUM
admet-850	244	10	)	)	PUNCT
admet-850	244	11	.	.	PUNCT
admet-850	245	1	[	[	X
admet-850	245	2	7	7	X
admet-850	245	3	]	]	PUNCT
admet-850	245	4	world	world	NOUN
admet-850	245	5	health	health	NOUN
admet-850	245	6	organization	organization	NOUN
admet-850	245	7	,	,	PUNCT
admet-850	245	8	who	who	PRON
admet-850	245	9	expert	expert	VERB
admet-850	245	10	committee	committee	NOUN
admet-850	245	11	on	on	ADP
admet-850	245	12	specifications	specification	NOUN
admet-850	245	13	for	for	ADP
admet-850	245	14	pharmaceutical	pharmaceutical	ADJ
admet-850	245	15	preparations	preparation	NOUN
admet-850	245	16	the	the	DET
admet-850	245	17	expert	expert	PROPN
admet-850	245	18	committee	committee	NOUN
admet-850	245	19	on	on	ADP
admet-850	245	20	specifications	specification	NOUN
admet-850	245	21	for	for	ADP
admet-850	245	22	pharmaceutical	pharmaceutical	NOUN
admet-850	245	23	,	,	PUNCT
admet-850	245	24	world	world	NOUN
admet-850	245	25	health	health	NOUN
admet-850	245	26	organization	organization	PROPN
admet-850	245	27	,	,	PUNCT
admet-850	245	28	geneva	geneva	PROPN
admet-850	245	29	,	,	PUNCT
admet-850	245	30	2020	2020	NUM
admet-850	245	31	.	.	PUNCT
admet-850	246	1	https://apps.who.int/iris/handle/10665/331814	https://apps.who.int/iris/handle/10665/331814	PROPN
admet-850	246	2	(	(	PUNCT
admet-850	246	3	accessed	access	VERB
admet-850	246	4	may	may	PROPN
admet-850	246	5	6	6	NUM
admet-850	246	6	,	,	PUNCT
admet-850	246	7	2020	2020	NUM
admet-850	246	8	)	)	PUNCT
admet-850	246	9	.	.	PUNCT
admet-850	247	1	[	[	X
admet-850	247	2	8	8	NUM
admet-850	247	3	]	]	PUNCT
admet-850	247	4	world	world	NOUN
admet-850	247	5	health	health	NOUN
admet-850	247	6	organization	organization	NOUN
admet-850	247	7	,	,	PUNCT
admet-850	247	8	the	the	DET
admet-850	247	9	international	international	ADJ
admet-850	247	10	pharmacopoeia	pharmacopoeia	NOUN
admet-850	247	11	,	,	PUNCT
admet-850	247	12	ninth	ninth	ADJ
admet-850	247	13	edition	edition	NOUN
admet-850	247	14	,	,	PUNCT
admet-850	247	15	(	(	PUNCT
admet-850	247	16	2019	2019	NUM
admet-850	247	17	)	)	PUNCT
admet-850	247	18	.	.	PUNCT
admet-850	248	1	https://apps.who.int/phint/en/p/docf/	https://apps.who.int/phint/en/p/docf/	PROPN
admet-850	248	2	(	(	PUNCT
admet-850	248	3	accessed	access	VERB
admet-850	248	4	may	may	PROPN
admet-850	248	5	6	6	NUM
admet-850	248	6	,	,	PUNCT
admet-850	248	7	2020	2020	NUM
admet-850	248	8	)	)	PUNCT
admet-850	248	9	.	.	PUNCT
admet-850	249	1	[	[	X
admet-850	249	2	9	9	NUM
admet-850	249	3	]	]	PUNCT
admet-850	249	4	world	world	NOUN
admet-850	249	5	health	health	NOUN
admet-850	249	6	organization	organization	NOUN
admet-850	249	7	,	,	PUNCT
admet-850	249	8	annex	annex	VERB
admet-850	249	9	4	4	NUM
admet-850	249	10	protocol	protocol	NOUN
admet-850	249	11	to	to	PART
admet-850	249	12	conduct	conduct	VERB
admet-850	249	13	equilibrium	equilibrium	NOUN
admet-850	249	14	solubility	solubility	NOUN
admet-850	249	15	experiments	experiment	NOUN
admet-850	249	16	for	for	ADP
admet-850	249	17	the	the	DET
admet-850	249	18	purpose	purpose	NOUN
admet-850	249	19	of	of	ADP
admet-850	249	20	biopharmaceutics	biopharmaceutics	NOUN
admet-850	249	21	classification	classification	NOUN
admet-850	249	22	system	system	NOUN
admet-850	249	23	-	-	PUNCT
admet-850	249	24	based	base	VERB
admet-850	249	25	classification	classification	NOUN
admet-850	249	26	of	of	ADP
admet-850	249	27	active	active	ADJ
admet-850	249	28	pharmaceutical	pharmaceutical	ADJ
admet-850	249	29	ingredients	ingredient	NOUN
admet-850	249	30	for	for	ADP
admet-850	249	31	biowaiver	biowaiver	NOUN
admet-850	249	32	,	,	PUNCT
admet-850	249	33	in	in	ADP
admet-850	249	34	:	:	PUNCT
admet-850	249	35	who	who	PRON
admet-850	249	36	expert	expert	VERB
admet-850	249	37	comm	comm	NOUN
admet-850	249	38	.	.	PUNCT
admet-850	250	1	specif	specif	PROPN
admet-850	250	2	.	.	PUNCT
admet-850	251	1	pharm	pharm	PROPN
admet-850	251	2	.	.	PUNCT
admet-850	252	1	prep	prep	NOUN
admet-850	252	2	.	.	PUNCT
admet-850	253	1	fifty	fifty	NUM
admet-850	253	2	-	-	PUNCT
admet-850	253	3	third	third	NOUN
admet-850	253	4	rep	rep	NOUN
admet-850	253	5	.	.	PROPN
admet-850	253	6	,	,	PUNCT
admet-850	253	7	2019	2019	NUM
admet-850	253	8	.	.	PUNCT
admet-850	254	1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.p	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.p	VERB
admet-850	254	2	df?ua=1	df?ua=1	NOUN
admet-850	254	3	(	(	PUNCT
admet-850	254	4	accessed	access	VERB
admet-850	254	5	may	may	PROPN
admet-850	254	6	6	6	NUM
admet-850	254	7	,	,	PUNCT
admet-850	254	8	2020	2020	NUM
admet-850	254	9	)	)	PUNCT
admet-850	254	10	.	.	PUNCT
admet-850	255	1	[	[	X
admet-850	255	2	10	10	NUM
admet-850	255	3	]	]	X
admet-850	255	4	c.a	c.a	PROPN
admet-850	255	5	.	.	PROPN
admet-850	255	6	larregieu	larregieu	PROPN
admet-850	255	7	,	,	PUNCT
admet-850	255	8	and	and	CCONJ
admet-850	255	9	l.z	l.z	PROPN
admet-850	255	10	.	.	PROPN
admet-850	255	11	benet	benet	PROPN
admet-850	255	12	.	.	PUNCT
admet-850	256	1	drug	drug	NOUN
admet-850	256	2	discovery	discovery	PROPN
admet-850	256	3	and	and	CCONJ
admet-850	256	4	regulatory	regulatory	ADJ
admet-850	256	5	considerations	consideration	NOUN
admet-850	256	6	for	for	ADP
admet-850	256	7	improving	improve	VERB
admet-850	256	8	in	in	ADP
admet-850	256	9	silico	silico	NOUN
admet-850	256	10	and	and	CCONJ
admet-850	256	11	in	in	ADP
admet-850	256	12	vitro	vitro	X
admet-850	256	13	predictions	prediction	NOUN
admet-850	256	14	that	that	PRON
admet-850	256	15	use	use	VERB
admet-850	256	16	caco-2	caco-2	NUM
admet-850	256	17	as	as	ADP
admet-850	256	18	a	a	DET
admet-850	256	19	surrogate	surrogate	NOUN
admet-850	256	20	for	for	ADP
admet-850	256	21	human	human	ADJ
admet-850	256	22	intestinal	intestinal	ADJ
admet-850	256	23	permeability	permeability	NOUN
admet-850	256	24	measurements	measurement	NOUN
admet-850	256	25	.	.	PUNCT
admet-850	257	1	aaps	aap	NOUN
admet-850	257	2	j.	j.	PROPN
admet-850	257	3	15	15	NUM
admet-850	257	4	(	(	PUNCT
admet-850	257	5	2013	2013	NUM
admet-850	257	6	)	)	PUNCT
admet-850	258	1	483–497	483–497	NUM
admet-850	258	2	.	.	PUNCT
admet-850	258	3	doi	doi	NOUN
admet-850	258	4	:	:	PUNCT
admet-850	258	5	https://doi.org/10.1208/s12248-013-9456-8	https://doi.org/10.1208/s12248-013-9456-8	NUM
admet-850	258	6	.	.	PUNCT
admet-850	259	1	[	[	X
admet-850	259	2	11	11	NUM
admet-850	259	3	]	]	X
admet-850	259	4	b.	b.	PROPN
admet-850	259	5	agoram	agoram	PROPN
admet-850	259	6	,	,	PUNCT
admet-850	259	7	w.s	w.s	PROPN
admet-850	259	8	.	.	PROPN
admet-850	259	9	woltosz	woltosz	PROPN
admet-850	259	10	,	,	PUNCT
admet-850	259	11	and	and	CCONJ
admet-850	259	12	m.b	m.b	PROPN
admet-850	259	13	.	.	PROPN
admet-850	259	14	bolger	bolger	PROPN
admet-850	259	15	.	.	PUNCT
admet-850	259	16	predicting	predict	VERB
admet-850	259	17	the	the	DET
admet-850	259	18	impact	impact	NOUN
admet-850	259	19	of	of	ADP
admet-850	259	20	physiological	physiological	ADJ
admet-850	259	21	and	and	CCONJ
admet-850	259	22	biochemical	biochemical	ADJ
admet-850	259	23	processes	process	NOUN
admet-850	259	24	on	on	ADP
admet-850	259	25	oral	oral	ADJ
admet-850	259	26	drug	drug	NOUN
admet-850	259	27	bioavailability	bioavailability	NOUN
admet-850	259	28	.	.	PUNCT
admet-850	260	1	adv	adv	PROPN
admet-850	260	2	.	.	PUNCT
admet-850	260	3	drug	drug	PROPN
admet-850	260	4	deliv	deliv	PROPN
admet-850	260	5	.	.	PUNCT
admet-850	261	1	rev	rev	PROPN
admet-850	261	2	.	.	PROPN
admet-850	261	3	50	50	NUM
admet-850	261	4	(	(	PUNCT
admet-850	261	5	2001	2001	NUM
admet-850	261	6	)	)	PUNCT
admet-850	261	7	.	.	PUNCT
admet-850	262	1	doi	doi	NOUN
admet-850	262	2	:	:	PUNCT
admet-850	262	3	https://doi.org/10.1016/s0169-409x(01)00179-x	https://doi.org/10.1016/s0169-409x(01)00179-x	NOUN
admet-850	262	4	.	.	PUNCT
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admet-850	263	5	http://www.who.int/	http://www.who.int/	PROPN
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admet-850	263	7	https://www.who.int/medicines/areas/quality_safety/quality_assurance/expert_committee/who_trs_1003_full-version.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/expert_committee/who_trs_1003_full-version.pdf?ua=1	PROPN
admet-850	263	8	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	X
admet-850	263	9	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	263	10	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/proposalwaivevivobioequivalencerequirementsmodellistessentialmedicinesimmediatereleasesolidoraldosageformstrs937annex8.pdf?ua=1	NOUN
admet-850	263	11	https://apps.who.int/iris/handle/10665/331814	https://apps.who.int/iris/handle/10665/331814	NOUN
admet-850	263	12	https://apps.who.int/phint/en/p/docf/	https://apps.who.int/phint/en/p/docf/	ADJ
admet-850	263	13	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.pdf?ua=1	NOUN
admet-850	263	14	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.pdf?ua=1	https://www.who.int/medicines/areas/quality_safety/quality_assurance/who_trs_1019_annex4.pdf?ua=1	NOUN
admet-850	263	15	https://doi.org/10.1208/s12248-013-9456-8	https://doi.org/10.1208/s12248-013-9456-8	NUM
admet-850	264	1	https://doi.org/10.1016/s0169-409x(01)00179-x	https://doi.org/10.1016/s0169-409x(01)00179-x	PROPN
admet-850	264	2	valeria	valeria	PROPN
admet-850	264	3	gigante	gigante	PROPN
admet-850	264	4	et	et	PROPN
admet-850	264	5	al	al	PROPN
admet-850	264	6	.	.	PROPN
admet-850	264	7	admet	admet	PROPN
admet-850	264	8	&	&	CCONJ
admet-850	264	9	dmpk	dmpk	PROPN
admet-850	264	10	9(1	9(1	NUM
admet-850	264	11	)	)	PUNCT
admet-850	264	12	(	(	PUNCT
admet-850	264	13	2021	2021	NUM
admet-850	264	14	)	)	PUNCT
admet-850	264	15	23	23	NUM
admet-850	264	16	-	-	SYM
admet-850	264	17	39	39	NUM
admet-850	264	18	38	38	NUM
admet-850	264	19	[	[	X
admet-850	264	20	12	12	NUM
admet-850	264	21	]	]	PUNCT
admet-850	264	22	a.	a.	NOUN
admet-850	264	23	avdeef	avdeef	PROPN
admet-850	264	24	,	,	PUNCT
admet-850	264	25	e.	e.	PROPN
admet-850	264	26	fuguet	fuguet	PROPN
admet-850	264	27	,	,	PUNCT
admet-850	264	28	a.	a.	PROPN
admet-850	264	29	llinàs	llinàs	PROPN
admet-850	264	30	,	,	PUNCT
admet-850	264	31	c.	c.	PROPN
admet-850	264	32	ràfols	ràfols	PROPN
admet-850	264	33	,	,	PUNCT
admet-850	264	34	e.	e.	PROPN
admet-850	264	35	bosch	bosch	PROPN
admet-850	264	36	,	,	PUNCT
admet-850	264	37	g.	g.	PROPN
admet-850	264	38	völgyi	völgyi	PROPN
admet-850	264	39	,	,	PUNCT
admet-850	264	40	t.	t.	PROPN
admet-850	264	41	verbic	verbic	NOUN
admet-850	264	42	,	,	PUNCT
admet-850	264	43	e.	e.	PROPN
admet-850	264	44	boldyreva	boldyreva	PROPN
admet-850	264	45	,	,	PUNCT
admet-850	264	46	and	and	CCONJ
admet-850	264	47	k.	k.	PROPN
admet-850	264	48	takácsnovák	takácsnovák	PROPN
admet-850	264	49	.	.	PUNCT
admet-850	265	1	equilibrium	equilibrium	NOUN
admet-850	265	2	solubility	solubility	NOUN
admet-850	265	3	measurement	measurement	NOUN
admet-850	265	4	of	of	ADP
admet-850	265	5	ionizable	ionizable	ADJ
admet-850	265	6	drugs	drug	NOUN
admet-850	265	7	consensus	consensus	NOUN
admet-850	265	8	recommendations	recommendation	NOUN
admet-850	265	9	for	for	ADP
admet-850	265	10	improving	improve	VERB
admet-850	265	11	data	datum	NOUN
admet-850	265	12	quality	quality	NOUN
admet-850	265	13	.	.	PUNCT
admet-850	266	1	admet	admet	PROPN
admet-850	266	2	dmpk	dmpk	PROPN
admet-850	266	3	4	4	NUM
admet-850	266	4	(	(	PUNCT
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admet-850	266	6	)	)	PUNCT
admet-850	267	1	117–178	117–178	NUM
admet-850	267	2	.	.	PUNCT
admet-850	267	3	doi	doi	NOUN
admet-850	267	4	:	:	PUNCT
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admet-850	267	6	.	.	PUNCT
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admet-850	268	2	13	13	NUM
admet-850	268	3	]	]	X
admet-850	268	4	d.	d.	PROPN
admet-850	268	5	thambavita	thambavita	PROPN
admet-850	268	6	,	,	PUNCT
admet-850	268	7	p.	p.	PROPN
admet-850	268	8	galappatthy	galappatthy	PROPN
admet-850	268	9	,	,	PUNCT
admet-850	268	10	u.	u.	PROPN
admet-850	268	11	mannapperuma	mannapperuma	PROPN
admet-850	268	12	,	,	PUNCT
admet-850	268	13	l.	l.	PROPN
admet-850	268	14	jayakody	jayakody	PROPN
admet-850	268	15	,	,	PUNCT
admet-850	268	16	r.	r.	PROPN
admet-850	268	17	cristofoletti	cristofoletti	PROPN
admet-850	268	18	,	,	PUNCT
admet-850	268	19	b.	b.	PROPN
admet-850	268	20	abrahamsson	abrahamsson	PROPN
admet-850	268	21	,	,	PUNCT
admet-850	268	22	d.w	d.w	PROPN
admet-850	268	23	.	.	PROPN
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admet-850	268	25	,	,	PUNCT
admet-850	268	26	p.	p.	NOUN
admet-850	268	27	langguth	langguth	NOUN
admet-850	268	28	,	,	PUNCT
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admet-850	268	31	,	,	PUNCT
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admet-850	268	33	parr	parr	PROPN
admet-850	268	34	,	,	PUNCT
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admet-850	268	36	.	.	PROPN
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admet-850	268	38	,	,	PUNCT
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admet-850	268	40	.	.	PROPN
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admet-850	268	42	,	,	PUNCT
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admet-850	268	44	j.	j.	PROPN
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admet-850	268	46	.	.	PUNCT
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admet-850	269	5	-	-	PUNCT
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admet-850	269	7	solid	solid	ADJ
admet-850	269	8	oral	oral	ADJ
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admet-850	269	10	forms	form	NOUN
admet-850	269	11	:	:	PUNCT
admet-850	269	12	amoxicillin	amoxicillin	NOUN
admet-850	269	13	trihydrate	trihydrate	NOUN
admet-850	269	14	.	.	PUNCT
admet-850	270	1	j.	j.	PROPN
admet-850	270	2	pharm	pharm	PROPN
admet-850	270	3	.	.	PUNCT
admet-850	271	1	sci	sci	PROPN
admet-850	271	2	.	.	PROPN
admet-850	272	1	106	106	NUM
admet-850	273	1	(	(	PUNCT
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admet-850	273	3	)	)	PUNCT
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admet-850	273	5	.	.	PUNCT
admet-850	273	6	doi	doi	NOUN
admet-850	273	7	:	:	PUNCT
admet-850	273	8	https://doi.org/10.1016/j.xphs.2017.04.068	https://doi.org/10.1016/j.xphs.2017.04.068	NUM
admet-850	273	9	.	.	PUNCT
admet-850	274	1	[	[	X
admet-850	274	2	14	14	NUM
admet-850	274	3	]	]	X
admet-850	274	4	j.	j.	PROPN
admet-850	274	5	arnal	arnal	PROPN
admet-850	274	6	,	,	PUNCT
admet-850	274	7	i.	i.	PROPN
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admet-850	274	9	-	-	PUNCT
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admet-850	274	11	,	,	PUNCT
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admet-850	274	14	,	,	PUNCT
admet-850	274	15	g.l	g.l	PROPN
admet-850	274	16	.	.	PROPN
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admet-850	274	18	,	,	PUNCT
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admet-850	274	20	.	.	PROPN
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admet-850	274	45	.	.	PUNCT
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admet-850	275	8	dosage	dosage	NOUN
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admet-850	275	10	:	:	PUNCT
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admet-850	276	1	j.	j.	PROPN
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admet-850	276	3	.	.	PUNCT
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admet-850	277	2	.	.	PROPN
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admet-850	277	6	)	)	PUNCT
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admet-850	277	8	.	.	PUNCT
admet-850	278	1	doi	doi	NOUN
admet-850	278	2	:	:	PUNCT
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admet-850	278	4	.	.	PUNCT
admet-850	279	1	[	[	X
admet-850	279	2	15	15	NUM
admet-850	279	3	]	]	X
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admet-850	279	10	t.	t.	PROPN
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admet-850	279	15	,	,	PUNCT
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admet-850	279	19	n.	n.	PROPN
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admet-850	279	22	s.	s.	PROPN
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admet-850	279	25	y.	y.	PROPN
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admet-850	279	37	y.	y.	PROPN
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admet-850	279	42	,	,	PUNCT
admet-850	279	43	m.	m.	NOUN
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admet-850	279	46	t.	t.	PROPN
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admet-850	280	18	)	)	PUNCT
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admet-850	280	21	.	.	PUNCT
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admet-850	281	4	(	(	PUNCT
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admet-850	281	6	)	)	PUNCT
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admet-850	282	2	.	.	PUNCT
admet-850	283	1	doi	doi	NOUN
admet-850	283	2	:	:	PUNCT
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admet-850	283	4	.	.	PUNCT
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admet-850	285	8	-	-	PUNCT
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admet-850	287	2	.	.	PUNCT
admet-850	288	1	doi	doi	PROPN
admet-850	288	2	:	:	PUNCT
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admet-850	289	4	a.	a.	NOUN
admet-850	289	5	katritzky	katritzky	PROPN
admet-850	289	6	,	,	PUNCT
admet-850	289	7	y.	y.	PROPN
admet-850	289	8	wang	wang	PROPN
admet-850	289	9	,	,	PUNCT
admet-850	289	10	s.	s.	PROPN
admet-850	289	11	sild	sild	PROPN
admet-850	289	12	,	,	PUNCT
admet-850	289	13	t.	t.	PROPN
admet-850	289	14	tamm	tamm	PROPN
admet-850	289	15	,	,	PUNCT
admet-850	289	16	and	and	CCONJ
admet-850	289	17	m.	m.	PROPN
admet-850	289	18	karelson	karelson	PROPN
admet-850	289	19	.	.	PUNCT
admet-850	290	1	qspr	qspr	PROPN
admet-850	290	2	studies	study	NOUN
admet-850	290	3	on	on	ADP
admet-850	290	4	vapor	vapor	NOUN
admet-850	290	5	pressure	pressure	NOUN
admet-850	290	6	,	,	PUNCT
admet-850	290	7	aqueous	aqueous	ADJ
admet-850	290	8	solubility	solubility	NOUN
admet-850	290	9	,	,	PUNCT
admet-850	290	10	and	and	CCONJ
admet-850	290	11	the	the	DET
admet-850	290	12	prediction	prediction	NOUN
admet-850	290	13	of	of	ADP
admet-850	290	14	water−air	water−air	PROPN
admet-850	290	15	partition	partition	NOUN
admet-850	290	16	coefficients	coefficient	NOUN
admet-850	290	17	.	.	PUNCT
admet-850	291	1	j.	j.	PROPN
admet-850	291	2	chem	chem	PROPN
admet-850	291	3	.	.	PUNCT
admet-850	292	1	inf	inf	PROPN
admet-850	292	2	.	.	PUNCT
admet-850	292	3	comput	comput	PROPN
admet-850	292	4	.	.	PUNCT
admet-850	293	1	sci	sci	PROPN
admet-850	293	2	.	.	PROPN
admet-850	294	1	38	38	NUM
admet-850	294	2	(	(	PUNCT
admet-850	294	3	1998	1998	NUM
admet-850	294	4	)	)	PUNCT
admet-850	295	1	720–725	720–725	NUM
admet-850	295	2	.	.	PUNCT
admet-850	296	1	doi	doi	PROPN
admet-850	296	2	:	:	PUNCT
admet-850	296	3	https://doi.org/10.1021/ci980022	https://doi.org/10.1021/ci980022	X
admet-850	296	4	t.	t.	X
admet-850	297	1	[	[	X
admet-850	297	2	18	18	NUM
admet-850	297	3	]	]	X
admet-850	297	4	m.a	m.a	PROPN
admet-850	297	5	.	.	PROPN
admet-850	297	6	hofsäss	hofsäss	PROPN
admet-850	297	7	,	,	PUNCT
admet-850	297	8	and	and	CCONJ
admet-850	297	9	j.b	j.b	PROPN
admet-850	297	10	.	.	PUNCT
admet-850	297	11	dressman	dressman	PROPN
admet-850	297	12	.	.	PUNCT
admet-850	298	1	the	the	DET
admet-850	298	2	discriminatory	discriminatory	ADJ
admet-850	298	3	power	power	NOUN
admet-850	298	4	of	of	ADP
admet-850	298	5	the	the	DET
admet-850	298	6	bcs	bcs	NOUN
admet-850	298	7	-	-	PUNCT
admet-850	298	8	based	base	VERB
admet-850	298	9	biowaiver	biowaiver	NOUN
admet-850	298	10	:	:	PUNCT
admet-850	298	11	a	a	DET
admet-850	298	12	retrospective	retrospective	NOUN
admet-850	298	13	with	with	ADP
admet-850	298	14	focus	focus	NOUN
admet-850	298	15	on	on	ADP
admet-850	298	16	essential	essential	ADJ
admet-850	298	17	medicines	medicine	NOUN
admet-850	298	18	.	.	PUNCT
admet-850	299	1	j.	j.	PROPN
admet-850	299	2	pharm	pharm	PROPN
admet-850	299	3	.	.	PUNCT
admet-850	300	1	sci	sci	PROPN
admet-850	300	2	.	.	PROPN
admet-850	301	1	108	108	NUM
admet-850	301	2	(	(	PUNCT
admet-850	301	3	2019	2019	NUM
admet-850	301	4	)	)	PUNCT
admet-850	301	5	2824–2837	2824–2837	NOUN
admet-850	301	6	.	.	PUNCT
admet-850	302	1	doi	doi	NOUN
admet-850	302	2	:	:	PUNCT
admet-850	302	3	https://doi.org/10.1016/j.xphs.2019.04.030	https://doi.org/10.1016/j.xphs.2019.04.030	NOUN
admet-850	302	4	.	.	PUNCT
admet-850	303	1	[	[	X
admet-850	303	2	19	19	NUM
admet-850	303	3	]	]	X
admet-850	303	4	g.	g.	PROPN
admet-850	303	5	paintaud	paintaud	PROPN
admet-850	303	6	,	,	PUNCT
admet-850	303	7	g.	g.	PROPN
admet-850	303	8	alván	alván	PROPN
admet-850	303	9	,	,	PUNCT
admet-850	303	10	m.l	m.l	PROPN
admet-850	303	11	.	.	PROPN
admet-850	303	12	dahl	dahl	PROPN
admet-850	303	13	,	,	PUNCT
admet-850	303	14	a.	a.	PROPN
admet-850	303	15	grahnén	grahnén	PROPN
admet-850	303	16	,	,	PUNCT
admet-850	303	17	j.	j.	PROPN
admet-850	303	18	sjövall	sjövall	PROPN
admet-850	303	19	,	,	PUNCT
admet-850	303	20	and	and	CCONJ
admet-850	303	21	j.o	j.o	PROPN
admet-850	303	22	.	.	PROPN
admet-850	303	23	svensson	svensson	PROPN
admet-850	303	24	.	.	PUNCT
admet-850	304	1	nonlinearity	nonlinearity	NOUN
admet-850	304	2	of	of	ADP
admet-850	304	3	amoxicillin	amoxicillin	PROPN
admet-850	304	4	absorption	absorption	NOUN
admet-850	304	5	kinetics	kinetic	NOUN
admet-850	304	6	in	in	ADP
admet-850	304	7	human	human	PROPN
admet-850	304	8	.	.	PUNCT
admet-850	305	1	eur	eur	PROPN
admet-850	305	2	.	.	PUNCT
admet-850	306	1	j.	j.	PROPN
admet-850	306	2	clin	clin	PROPN
admet-850	306	3	.	.	PUNCT
admet-850	307	1	pharmacol	pharmacol	PROPN
admet-850	307	2	.	.	PUNCT
admet-850	308	1	43	43	NUM
admet-850	308	2	(	(	PUNCT
admet-850	308	3	1992	1992	NUM
admet-850	308	4	)	)	PUNCT
admet-850	309	1	283–288	283–288	NUM
admet-850	309	2	.	.	PUNCT
admet-850	310	1	doi	doi	NOUN
admet-850	310	2	:	:	PUNCT
admet-850	310	3	https://doi.org/10.1007/bf02333024	https://doi.org/10.1007/bf02333024	NUM
admet-850	310	4	.	.	PUNCT
admet-850	311	1	[	[	X
admet-850	311	2	20	20	NUM
admet-850	311	3	]	]	PUNCT
admet-850	311	4	p.	p.	NOUN
admet-850	311	5	luckner	luckner	NOUN
admet-850	311	6	,	,	PUNCT
admet-850	311	7	and	and	CCONJ
admet-850	311	8	m.	m.	NOUN
admet-850	311	9	brandsch	brandsch	NOUN
admet-850	311	10	.	.	PUNCT
admet-850	312	1	interaction	interaction	NOUN
admet-850	312	2	of	of	ADP
admet-850	312	3	31	31	NUM
admet-850	312	4	β	β	NOUN
admet-850	312	5	-	-	PUNCT
admet-850	312	6	lactam	lactam	NOUN
admet-850	312	7	antibiotics	antibiotic	NOUN
admet-850	312	8	with	with	ADP
admet-850	312	9	the	the	DET
admet-850	312	10	h	h	NOUN
admet-850	312	11	+	+	ADJ
admet-850	312	12	/peptide	/peptide	ADJ
admet-850	312	13	symporter	symporter	ADJ
admet-850	312	14	pept2	pept2	NOUN
admet-850	312	15	:	:	PUNCT
admet-850	312	16	analysis	analysis	NOUN
admet-850	312	17	of	of	ADP
admet-850	312	18	affinity	affinity	NOUN
admet-850	312	19	constants	constant	NOUN
admet-850	312	20	and	and	CCONJ
admet-850	312	21	comparison	comparison	NOUN
admet-850	312	22	with	with	ADP
admet-850	312	23	pept1	pept1	PROPN
admet-850	312	24	.	.	PUNCT
admet-850	312	25	eur	eur	PROPN
admet-850	312	26	.	.	PUNCT
admet-850	313	1	j.	j.	PROPN
admet-850	313	2	pharm	pharm	PROPN
admet-850	313	3	.	.	PUNCT
admet-850	314	1	biopharm	biopharm	PROPN
admet-850	314	2	.	.	PUNCT
admet-850	315	1	59	59	NUM
admet-850	315	2	(	(	PUNCT
admet-850	315	3	2005	2005	NUM
admet-850	315	4	)	)	PUNCT
admet-850	315	5	17–24	17–24	NUM
admet-850	315	6	.	.	PUNCT
admet-850	316	1	doi	doi	NOUN
admet-850	316	2	:	:	PUNCT
admet-850	316	3	https://doi.org/10.1016/j.ejpb.2004.07.008	https://doi.org/10.1016/j.ejpb.2004.07.008	NOUN
admet-850	316	4	.	.	PUNCT
admet-850	317	1	[	[	X
admet-850	317	2	21	21	NUM
admet-850	317	3	]	]	X
admet-850	317	4	t.t	t.t	PROPN
admet-850	317	5	.	.	PROPN
admet-850	317	6	mariappan	mariappan	PROPN
admet-850	317	7	,	,	PUNCT
admet-850	317	8	and	and	CCONJ
admet-850	317	9	s.	s.	PROPN
admet-850	317	10	singh	singh	PROPN
admet-850	317	11	.	.	PUNCT
admet-850	318	1	evidence	evidence	NOUN
admet-850	318	2	of	of	ADP
admet-850	318	3	efflux	efflux	NOUN
admet-850	318	4	-	-	PUNCT
admet-850	318	5	mediated	mediate	VERB
admet-850	318	6	and	and	CCONJ
admet-850	318	7	saturable	saturable	ADJ
admet-850	318	8	absorption	absorption	NOUN
admet-850	318	9	of	of	ADP
admet-850	318	10	rifampicin	rifampicin	VERB
admet-850	318	11	in	in	ADP
admet-850	318	12	rat	rat	NOUN
admet-850	318	13	intestine	intestine	NOUN
admet-850	318	14	using	use	VERB
admet-850	318	15	the	the	DET
admet-850	318	16	ligated	ligate	VERB
admet-850	318	17	loop	loop	NOUN
admet-850	318	18	and	and	CCONJ
admet-850	318	19	everted	evert	VERB
admet-850	318	20	gut	gut	NOUN
admet-850	318	21	sac	sac	NOUN
admet-850	318	22	techniques	technique	NOUN
admet-850	318	23	.	.	PUNCT
admet-850	319	1	mol	mol	PROPN
admet-850	319	2	.	.	PUNCT
admet-850	319	3	pharm	pharm	PROPN
admet-850	319	4	.	.	PUNCT
admet-850	320	1	1	1	NUM
admet-850	320	2	(	(	PUNCT
admet-850	320	3	2004	2004	NUM
admet-850	320	4	)	)	PUNCT
admet-850	321	1	363–367	363–367	NUM
admet-850	321	2	.	.	PUNCT
admet-850	322	1	doi	doi	PROPN
admet-850	322	2	:	:	PUNCT
admet-850	322	3	https://doi.org/10.1021/mp049937n	https://doi.org/10.1021/mp049937n	PROPN
admet-850	322	4	.	.	PUNCT
admet-850	323	1	[	[	X
admet-850	323	2	22	22	NUM
admet-850	323	3	]	]	PUNCT
admet-850	323	4	m.	m.	NOUN
admet-850	323	5	bermejo	bermejo	PROPN
admet-850	323	6	,	,	PUNCT
admet-850	323	7	b.	b.	PROPN
admet-850	323	8	hens	hens	PROPN
admet-850	323	9	,	,	PUNCT
admet-850	323	10	j.	j.	PROPN
admet-850	323	11	dickens	dickens	PROPN
admet-850	323	12	,	,	PUNCT
admet-850	323	13	d.	d.	PROPN
admet-850	323	14	mudie	mudie	PROPN
admet-850	323	15	,	,	PUNCT
admet-850	323	16	p.	p.	NOUN
admet-850	323	17	paixão	paixão	PROPN
admet-850	323	18	,	,	PUNCT
admet-850	323	19	y.	y.	PROPN
admet-850	323	20	tsume	tsume	PROPN
admet-850	323	21	,	,	PUNCT
admet-850	323	22	k.	k.	PROPN
admet-850	323	23	shedden	shedden	PROPN
admet-850	323	24	,	,	PUNCT
admet-850	323	25	and	and	CCONJ
admet-850	323	26	g.l	g.l	PROPN
admet-850	323	27	.	.	PROPN
admet-850	323	28	amidon	amidon	PROPN
admet-850	323	29	.	.	PUNCT
admet-850	324	1	a	a	DET
admet-850	324	2	mechanistic	mechanistic	ADJ
admet-850	324	3	physiologically	physiologically	ADV
admet-850	324	4	-	-	PUNCT
admet-850	324	5	based	base	VERB
admet-850	324	6	biopharmaceutics	biopharmaceutics	NOUN
admet-850	324	7	modeling	modeling	NOUN
admet-850	324	8	(	(	PUNCT
admet-850	324	9	pbbm	pbbm	NOUN
admet-850	324	10	)	)	PUNCT
admet-850	324	11	approach	approach	NOUN
admet-850	324	12	to	to	PART
admet-850	324	13	assess	assess	VERB
admet-850	324	14	the	the	DET
admet-850	324	15	in	in	ADP
admet-850	324	16	vivo	vivo	ADJ
admet-850	324	17	performance	performance	NOUN
admet-850	324	18	of	of	ADP
admet-850	324	19	an	an	DET
admet-850	324	20	orally	orally	ADV
admet-850	324	21	administered	administer	VERB
admet-850	324	22	drug	drug	NOUN
admet-850	324	23	product	product	NOUN
admet-850	324	24	:	:	PUNCT
admet-850	324	25	from	from	ADP
admet-850	324	26	ivivc	ivivc	NOUN
admet-850	324	27	to	to	PART
admet-850	324	28	ivivp	ivivp	VERB
admet-850	324	29	.	.	PUNCT
admet-850	325	1	pharmaceutics	pharmaceutic	NOUN
admet-850	325	2	12	12	NUM
admet-850	325	3	(	(	PUNCT
admet-850	325	4	2020	2020	NUM
admet-850	325	5	)	)	PUNCT
admet-850	325	6	.	.	PUNCT
admet-850	326	1	doi	doi	NOUN
admet-850	326	2	:	:	PUNCT
admet-850	326	3	https://doi.org/10.3390/pharmaceutics12010074	https://doi.org/10.3390/pharmaceutics12010074	PROPN
admet-850	326	4	.	.	PUNCT
admet-850	327	1	[	[	X
admet-850	327	2	23	23	NUM
admet-850	327	3	]	]	X
admet-850	327	4	r.	r.	PROPN
admet-850	327	5	jereb	jereb	PROPN
admet-850	327	6	,	,	PUNCT
admet-850	327	7	j.	j.	PROPN
admet-850	327	8	opara	opara	PROPN
admet-850	327	9	,	,	PUNCT
admet-850	327	10	i.	i.	PROPN
admet-850	327	11	legen	legen	PROPN
admet-850	327	12	,	,	PUNCT
admet-850	327	13	b.	b.	PROPN
admet-850	327	14	petek	petek	NOUN
admet-850	327	15	,	,	PUNCT
admet-850	327	16	and	and	CCONJ
admet-850	327	17	d.	d.	PROPN
admet-850	327	18	grabnar	grabnar	PROPN
admet-850	327	19	-	-	PUNCT
admet-850	327	20	peklar	peklar	ADJ
admet-850	327	21	.	.	PUNCT
admet-850	328	1	in	in	ADP
admet-850	328	2	vitro	vitro	X
admet-850	328	3	–	–	PUNCT
admet-850	328	4	in	in	ADP
admet-850	328	5	vivo	vivo	NOUN
admet-850	328	6	relationship	relationship	NOUN
admet-850	328	7	and	and	CCONJ
admet-850	328	8	bioequivalence	bioequivalence	NOUN
admet-850	328	9	prediction	prediction	NOUN
admet-850	328	10	for	for	ADP
admet-850	328	11	modified	modify	VERB
admet-850	328	12	-	-	PUNCT
admet-850	328	13	release	release	NOUN
admet-850	328	14	capsules	capsule	NOUN
admet-850	328	15	based	base	VERB
admet-850	328	16	on	on	ADP
admet-850	328	17	a	a	DET
admet-850	328	18	pbpk	pbpk	ADJ
admet-850	328	19	absorption	absorption	NOUN
admet-850	328	20	model	model	NOUN
admet-850	328	21	.	.	PUNCT
admet-850	329	1	aaps	aap	NOUN
admet-850	329	2	pharmscitech	pharmscitech	VERB
admet-850	329	3	21	21	NUM
admet-850	329	4	(	(	PUNCT
admet-850	329	5	2020	2020	NUM
admet-850	329	6	)	)	PUNCT
admet-850	329	7	.	.	PUNCT
admet-850	330	1	doi	doi	NOUN
admet-850	330	2	:	:	PUNCT
admet-850	330	3	https://doi.org/10.1208/s12249-019-1566-x	https://doi.org/10.1208/s12249-019-1566-x	NOUN
admet-850	330	4	.	.	PUNCT
admet-850	331	1	[	[	X
admet-850	331	2	24	24	NUM
admet-850	331	3	]	]	X
admet-850	331	4	p.	p.	NOUN
admet-850	331	5	de	de	X
admet-850	331	6	miranda	miranda	PROPN
admet-850	331	7	,	,	PUNCT
admet-850	331	8	and	and	CCONJ
admet-850	331	9	m.	m.	PROPN
admet-850	331	10	blum	blum	PROPN
admet-850	331	11	.	.	PUNCT
admet-850	332	1	pharmacokinetics	pharmacokinetic	NOUN
admet-850	332	2	of	of	ADP
admet-850	332	3	acyclovir	acyclovir	PROPN
admet-850	332	4	after	after	ADP
admet-850	332	5	intravenous	intravenous	ADJ
admet-850	332	6	and	and	CCONJ
admet-850	332	7	oral	oral	ADJ
admet-850	332	8	administration	administration	NOUN
admet-850	332	9	.	.	PUNCT
admet-850	333	1	j.	j.	PROPN
admet-850	333	2	antimicrob	antimicrob	PROPN
admet-850	333	3	.	.	PUNCT
admet-850	334	1	chemother	chemother	PROPN
admet-850	334	2	.	.	PUNCT
admet-850	335	1	12	12	NUM
admet-850	335	2	(	(	PUNCT
admet-850	335	3	1983	1983	NUM
admet-850	335	4	)	)	PUNCT
admet-850	336	1	29–37	29–37	NOUN
admet-850	336	2	.	.	PUNCT
admet-850	337	1	doi	doi	NOUN
admet-850	337	2	:	:	PUNCT
admet-850	337	3	https://doi.org/10.1093/jac/12.suppl_b.29	https://doi.org/10.1093/jac/12.suppl_b.29	NOUN
admet-850	337	4	.	.	PUNCT
admet-850	338	1	[	[	X
admet-850	338	2	25	25	NUM
admet-850	338	3	]	]	X
admet-850	338	4	g.	g.	PROPN
admet-850	338	5	foulds	foulds	PROPN
admet-850	338	6	,	,	PUNCT
admet-850	338	7	r.	r.	PROPN
admet-850	338	8	shepard	shepard	NOUN
admet-850	338	9	,	,	PUNCT
admet-850	338	10	and	and	CCONJ
admet-850	338	11	r.	r.	PROPN
admet-850	338	12	johnson	johnson	PROPN
admet-850	338	13	.	.	PUNCT
admet-850	339	1	the	the	DET
admet-850	339	2	pharmacokinetics	pharmacokinetic	NOUN
admet-850	339	3	of	of	ADP
admet-850	339	4	azithromycin	azithromycin	NOUN
admet-850	339	5	in	in	ADP
admet-850	339	6	human	human	ADJ
admet-850	339	7	serum	serum	NOUN
admet-850	339	8	and	and	CCONJ
admet-850	339	9	tissues	tissue	NOUN
admet-850	339	10	.	.	PUNCT
admet-850	340	1	pubmed	pubmed	PROPN
admet-850	340	2	ncbi	ncbi	PROPN
admet-850	340	3	.	.	PUNCT
admet-850	341	1	j.	j.	PROPN
admet-850	341	2	antimicrob	antimicrob	PROPN
admet-850	341	3	.	.	PUNCT
admet-850	342	1	chemother	chemother	PROPN
admet-850	342	2	.	.	PUNCT
admet-850	343	1	25	25	NUM
admet-850	343	2	(	(	PUNCT
admet-850	343	3	1990	1990	NUM
admet-850	343	4	)	)	PUNCT
admet-850	344	1	73–82	73–82	NUM
admet-850	344	2	.	.	PUNCT
admet-850	344	3	doi	doi	NOUN
admet-850	344	4	:	:	PUNCT
admet-850	344	5	https://doi.org/10.1093/jac/25.suppl_a.73	https://doi.org/10.1093/jac/25.suppl_a.73	PROPN
admet-850	344	6	.	.	PUNCT
admet-850	345	1	[	[	X
admet-850	345	2	26	26	NUM
admet-850	345	3	]	]	X
admet-850	345	4	r.d	r.d	PROPN
admet-850	345	5	.	.	PROPN
admet-850	345	6	faulkner	faulkner	PROPN
admet-850	345	7	,	,	PUNCT
admet-850	345	8	p.	p.	NOUN
admet-850	345	9	fernandez	fernandez	PROPN
admet-850	345	10	,	,	PUNCT
admet-850	345	11	g.	g.	PROPN
admet-850	345	12	lawrence	lawrence	PROPN
admet-850	345	13	,	,	PUNCT
admet-850	345	14	l.l	l.l	PROPN
admet-850	345	15	.	.	PROPN
admet-850	345	16	sia	sia	PROPN
admet-850	345	17	,	,	PUNCT
admet-850	345	18	a.j	a.j	PROPN
admet-850	345	19	.	.	PROPN
admet-850	345	20	falkowski	falkowski	PROPN
admet-850	345	21	,	,	PUNCT
admet-850	345	22	a.i	a.i	PROPN
admet-850	345	23	.	.	PROPN
admet-850	345	24	weiss	weiss	PROPN
admet-850	345	25	,	,	PUNCT
admet-850	345	26	a.	a.	NOUN
admet-850	345	27	yacobi	yacobi	PROPN
admet-850	345	28	,	,	PUNCT
admet-850	345	29	and	and	CCONJ
admet-850	345	30	b.m	b.m	PROPN
admet-850	345	31	.	.	PROPN
admet-850	345	32	silber	silber	PROPN
admet-850	345	33	.	.	PUNCT
admet-850	346	1	absolute	absolute	ADJ
admet-850	346	2	bioavailability	bioavailability	NOUN
admet-850	346	3	of	of	ADP
admet-850	346	4	cefixime	cefixime	NOUN
admet-850	346	5	in	in	ADP
admet-850	346	6	man	man	NOUN
admet-850	346	7	.	.	PUNCT
admet-850	347	1	j.	j.	PROPN
admet-850	347	2	clin	clin	PROPN
admet-850	347	3	.	.	PUNCT
admet-850	348	1	pharmacol	pharmacol	PROPN
admet-850	348	2	.	.	PUNCT
admet-850	349	1	28	28	NUM
admet-850	349	2	(	(	PUNCT
admet-850	349	3	1988	1988	NUM
admet-850	349	4	)	)	PUNCT
admet-850	350	1	700–706	700–706	NUM
admet-850	350	2	.	.	PUNCT
admet-850	350	3	doi	doi	NOUN
admet-850	350	4	:	:	PUNCT
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admet-850	350	6	.	.	PUNCT
admet-850	351	1	https://doi.org/10.5599/admet.4.2.292	https://doi.org/10.5599/admet.4.2.292	PRON
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admet-850	351	3	https://doi.org/10.1002/jps.21392	https://doi.org/10.1002/jps.21392	PROPN
admet-850	351	4	https://doi.org/10.5599/admet.704	https://doi.org/10.5599/admet.704	VERB
admet-850	351	5	https://doi.org/10.5599/admet.3.2.193	https://doi.org/10.5599/admet.3.2.193	PROPN
admet-850	351	6	https://doi.org/10.1021/ci980022	https://doi.org/10.1021/ci980022	PROPN
admet-850	351	7	t	t	PROPN
admet-850	351	8	https://doi.org/10.1016/j.xphs.2019.04.030	https://doi.org/10.1016/j.xphs.2019.04.030	PROPN
admet-850	351	9	https://doi.org/10.1007/bf02333024	https://doi.org/10.1007/bf02333024	NUM
admet-850	351	10	https://doi.org/10.1016/j.ejpb.2004.07.008	https://doi.org/10.1016/j.ejpb.2004.07.008	NOUN
admet-850	351	11	https://doi.org/10.1021/mp049937n	https://doi.org/10.1021/mp049937n	PROPN
admet-850	351	12	https://doi.org/10.3390/pharmaceutics12010074	https://doi.org/10.3390/pharmaceutics12010074	PROPN
admet-850	351	13	https://doi.org/10.1208/s12249-019-1566-x	https://doi.org/10.1208/s12249-019-1566-x	PROPN
admet-850	351	14	https://doi.org/10.1093/jac/12.suppl_b.29	https://doi.org/10.1093/jac/12.suppl_b.29	PROPN
admet-850	351	15	https://doi.org/10.1093/jac/25.suppl_a.73	https://doi.org/10.1093/jac/25.suppl_a.73	PUNCT
admet-850	351	16	https://doi.org/10.1002/j.1552-4604.1988.tb03203.x	https://doi.org/10.1002/j.1552-4604.1988.tb03203.x	PROPN
admet-850	351	17	admet	admet	PROPN
admet-850	351	18	&	&	CCONJ
admet-850	351	19	dmpk	dmpk	PROPN
admet-850	351	20	9(1	9(1	NUM
admet-850	351	21	)	)	PUNCT
admet-850	351	22	(	(	PUNCT
admet-850	351	23	2021	2021	NUM
admet-850	351	24	)	)	PUNCT
admet-850	351	25	23	23	NUM
admet-850	351	26	-	-	SYM
admet-850	351	27	39	39	NUM
admet-850	351	28	enhancing	enhance	VERB
admet-850	351	29	robustness	robustness	NOUN
admet-850	351	30	of	of	ADP
admet-850	351	31	the	the	PRON
admet-850	351	32	who	who	PRON
admet-850	351	33	biopharmaceutical	biopharmaceutical	ADJ
admet-850	351	34	classification	classification	NOUN
admet-850	351	35	system	system	NOUN
admet-850	351	36	doi	doi	NOUN
admet-850	351	37	:	:	PUNCT
admet-850	351	38	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	NOUN
admet-850	351	39	39	39	NUM
admet-850	352	1	[	[	SYM
admet-850	352	2	27	27	NUM
admet-850	352	3	]	]	X
admet-850	352	4	j.h	j.h	PROPN
admet-850	352	5	.	.	PROPN
admet-850	352	6	hull	hull	PROPN
admet-850	352	7	,	,	PUNCT
admet-850	352	8	j.w.a	j.w.a	PROPN
admet-850	352	9	.	.	PUNCT
admet-850	353	1	findlay	findlay	PROPN
admet-850	353	2	,	,	PUNCT
admet-850	353	3	j.f	j.f	PROPN
admet-850	353	4	.	.	PROPN
admet-850	353	5	rogers	rogers	PROPN
admet-850	353	6	,	,	PUNCT
admet-850	353	7	r.m	r.m	PROPN
admet-850	353	8	.	.	PROPN
admet-850	353	9	welch	welch	PROPN
admet-850	353	10	,	,	PUNCT
admet-850	353	11	r.f	r.f	PROPN
admet-850	353	12	.	.	PROPN
admet-850	353	13	butz	butz	PROPN
admet-850	353	14	,	,	PUNCT
admet-850	353	15	and	and	CCONJ
admet-850	353	16	j.a	j.a	PROPN
admet-850	353	17	.	.	PROPN
admet-850	353	18	bustrack	bustrack	PROPN
admet-850	353	19	.	.	PUNCT
admet-850	354	1	an	an	DET
admet-850	354	2	evaluation	evaluation	NOUN
admet-850	354	3	of	of	ADP
admet-850	354	4	the	the	DET
admet-850	354	5	effects	effect	NOUN
admet-850	354	6	of	of	ADP
admet-850	354	7	smoking	smoking	NOUN
admet-850	354	8	on	on	ADP
admet-850	354	9	codeine	codeine	NOUN
admet-850	354	10	pharmacokinetics	pharmacokinetic	NOUN
admet-850	354	11	and	and	CCONJ
admet-850	354	12	bioavailability	bioavailability	NOUN
admet-850	354	13	in	in	ADP
admet-850	354	14	normal	normal	ADJ
admet-850	354	15	human	human	ADJ
admet-850	354	16	volunteers	volunteer	NOUN
admet-850	354	17	.	.	PUNCT
admet-850	355	1	drug	drug	NOUN
admet-850	355	2	intell	intell	PROPN
admet-850	355	3	.	.	PUNCT
admet-850	356	1	clin	clin	PROPN
admet-850	356	2	.	.	PUNCT
admet-850	357	1	pharm	pharm	PROPN
admet-850	357	2	.	.	PUNCT
admet-850	358	1	16	16	NUM
admet-850	358	2	(	(	PUNCT
admet-850	358	3	1982	1982	NUM
admet-850	358	4	)	)	PUNCT
admet-850	358	5	849–854	849–854	NUM
admet-850	358	6	.	.	PUNCT
admet-850	359	1	doi	doi	NOUN
admet-850	359	2	:	:	PUNCT
admet-850	359	3	https://doi.org/10.1177/106002808201601107	https://doi.org/10.1177/106002808201601107	X
admet-850	359	4	.	.	PUNCT
admet-850	360	1	[	[	X
admet-850	360	2	28	28	NUM
admet-850	360	3	]	]	X
admet-850	360	4	y.	y.	PROPN
admet-850	360	5	gandhi	gandhi	PROPN
admet-850	360	6	,	,	PUNCT
admet-850	360	7	t.	t.	PROPN
admet-850	360	8	eley	eley	PROPN
admet-850	360	9	,	,	PUNCT
admet-850	360	10	a.	a.	PROPN
admet-850	360	11	fura	fura	PROPN
admet-850	360	12	,	,	PUNCT
admet-850	360	13	w.	w.	PROPN
admet-850	360	14	li	li	PROPN
admet-850	360	15	,	,	PUNCT
admet-850	360	16	r.j	r.j	PROPN
admet-850	360	17	.	.	PROPN
admet-850	360	18	bertz	bertz	PROPN
admet-850	360	19	,	,	PUNCT
admet-850	360	20	and	and	CCONJ
admet-850	360	21	t.	t.	PROPN
admet-850	360	22	garimella	garimella	PROPN
admet-850	360	23	.	.	PUNCT
admet-850	361	1	daclatasvir	daclatasvir	NOUN
admet-850	361	2	:	:	PUNCT
admet-850	362	1	a	a	DET
admet-850	362	2	review	review	NOUN
admet-850	362	3	of	of	ADP
admet-850	362	4	preclinical	preclinical	ADJ
admet-850	362	5	and	and	CCONJ
admet-850	362	6	clinical	clinical	ADJ
admet-850	362	7	pharmacokinetics	pharmacokinetic	NOUN
admet-850	362	8	.	.	PUNCT
admet-850	363	1	clin	clin	PROPN
admet-850	363	2	.	.	PUNCT
admet-850	363	3	pharmacokinet	pharmacokinet	PROPN
admet-850	363	4	.	.	PUNCT
admet-850	364	1	57	57	NUM
admet-850	364	2	(	(	PUNCT
admet-850	364	3	2018	2018	NUM
admet-850	364	4	)	)	PUNCT
admet-850	365	1	911–928	911–928	NUM
admet-850	365	2	.	.	PUNCT
admet-850	366	1	doi	doi	NOUN
admet-850	366	2	:	:	PUNCT
admet-850	366	3	https://doi.org/10.1007/s40262-017-0624-3	https://doi.org/10.1007/s40262-017-0624-3	NUM
admet-850	366	4	.	.	PUNCT
admet-850	367	1	[	[	X
admet-850	367	2	29	29	NUM
admet-850	367	3	]	]	X
admet-850	367	4	c.	c.	PROPN
admet-850	367	5	wolfe	wolfe	PROPN
admet-850	367	6	,	,	PUNCT
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admet-850	367	8	c.	c.	PROPN
admet-850	367	9	hicks	hicks	PROPN
admet-850	367	10	.	.	PUNCT
admet-850	368	1	profile	profile	NOUN
admet-850	368	2	of	of	ADP
admet-850	368	3	darunavir	darunavir	PROPN
admet-850	368	4	in	in	ADP
admet-850	368	5	the	the	DET
admet-850	368	6	management	management	NOUN
admet-850	368	7	of	of	ADP
admet-850	368	8	treatment	treatment	NOUN
admet-850	368	9	-	-	PUNCT
admet-850	368	10	experienced	experience	VERB
admet-850	368	11	hiv	hiv	PROPN
admet-850	368	12	patients	patient	NOUN
admet-850	368	13	.	.	PUNCT
admet-850	369	1	hiv	hiv	PROPN
admet-850	369	2	/	/	SYM
admet-850	369	3	aids	aids	PROPN
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admet-850	369	5	.	.	PROPN
admet-850	370	1	palliat	palliat	PROPN
admet-850	370	2	.	.	PUNCT
admet-850	371	1	care	care	PROPN
admet-850	371	2	.	.	PUNCT
admet-850	372	1	(	(	PUNCT
admet-850	372	2	2009	2009	NUM
admet-850	372	3	)	)	PUNCT
admet-850	372	4	13	13	NUM
admet-850	372	5	.	.	PUNCT
admet-850	373	1	doi	doi	NOUN
admet-850	373	2	:	:	PUNCT
admet-850	373	3	https://doi.org/10.2147/hiv.s4842	https://doi.org/10.2147/hiv.s4842	NOUN
admet-850	373	4	.	.	PUNCT
admet-850	374	1	[	[	X
admet-850	374	2	30	30	NUM
admet-850	374	3	]	]	X
admet-850	374	4	fda	fda	PROPN
admet-850	374	5	,	,	PUNCT
admet-850	374	6	dolutegravir	dolutegravir	PROPN
admet-850	374	7	.	.	PUNCT
admet-850	375	1	decisional	decisional	ADJ
admet-850	375	2	review	review	NOUN
admet-850	375	3	for	for	ADP
admet-850	375	4	nda	nda	PROPN
admet-850	375	5	204790	204790	NUM
admet-850	375	6	.	.	PUNCT
admet-850	375	7	,	,	PUNCT
admet-850	375	8	2013	2013	NUM
admet-850	375	9	.	.	PUNCT
admet-850	376	1	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=2	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=2	NOUN
admet-850	376	2	04790	04790	NUM
admet-850	376	3	(	(	PUNCT
admet-850	376	4	accessed	access	VERB
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admet-850	376	7	,	,	PUNCT
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admet-850	376	9	)	)	PUNCT
admet-850	376	10	.	.	PUNCT
admet-850	377	1	[	[	X
admet-850	377	2	31	31	NUM
admet-850	377	3	]	]	X
admet-850	377	4	fda	fda	PROPN
admet-850	377	5	,	,	PUNCT
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admet-850	377	8	history	history	NOUN
admet-850	377	9	:	:	PUNCT
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admet-850	377	12	20	20	NUM
admet-850	377	13	-	-	SYM
admet-850	377	14	360	360	NUM
admet-850	377	15	.	.	NUM
admet-850	377	16	,	,	PUNCT
admet-850	377	17	2011	2011	NUM
admet-850	377	18	.	.	PUNCT
admet-850	378	1	https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20972biopharm_review.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20972biopharm_review.pdf	NOUN
admet-850	378	2	.	.	PUNCT
admet-850	379	1	[	[	X
admet-850	379	2	32	32	NUM
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admet-850	379	5	.	.	PROPN
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admet-850	379	7	,	,	PUNCT
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admet-850	379	9	.	.	PROPN
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admet-850	379	11	,	,	PUNCT
admet-850	379	12	a.j	a.j	PROPN
admet-850	379	13	.	.	PROPN
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admet-850	379	15	-	-	PUNCT
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admet-850	379	17	,	,	PUNCT
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admet-850	379	20	,	,	PUNCT
admet-850	379	21	a.	a.	NOUN
admet-850	379	22	bekker	bekker	PROPN
admet-850	379	23	,	,	PUNCT
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admet-850	379	25	.	.	PROPN
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admet-850	379	28	a.c	a.c	PROPN
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admet-850	379	31	,	,	PUNCT
admet-850	379	32	h.	h.	PROPN
admet-850	379	33	simon	simon	PROPN
admet-850	379	34	schaaf	schaaf	PROPN
admet-850	379	35	,	,	PUNCT
admet-850	379	36	h.	h.	PROPN
admet-850	379	37	mcilleron	mcilleron	PROPN
admet-850	379	38	,	,	PUNCT
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admet-850	379	40	.	.	PROPN
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admet-850	379	42	,	,	PUNCT
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admet-850	379	45	denti	denti	PROPN
admet-850	379	46	.	.	PROPN
admet-850	379	47	,	,	PUNCT
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admet-850	379	49	pharmacokinetics	pharmacokinetic	NOUN
admet-850	379	50	and	and	CCONJ
admet-850	379	51	dosing	dosing	NOUN
admet-850	379	52	of	of	ADP
admet-850	379	53	ethionamide	ethionamide	NOUN
admet-850	379	54	in	in	ADP
admet-850	379	55	children	child	NOUN
admet-850	379	56	with	with	ADP
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admet-850	379	58	.	.	PUNCT
admet-850	380	1	antimicrob	antimicrob	PROPN
admet-850	380	2	.	.	PUNCT
admet-850	381	1	agents	agent	NOUN
admet-850	381	2	chemother	chemother	PROPN
admet-850	381	3	.	.	PUNCT
admet-850	382	1	64	64	NUM
admet-850	382	2	(	(	PUNCT
admet-850	382	3	2020	2020	NUM
admet-850	382	4	)	)	PUNCT
admet-850	382	5	.	.	PUNCT
admet-850	383	1	doi	doi	NOUN
admet-850	383	2	:	:	PUNCT
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admet-850	383	4	.	.	PUNCT
admet-850	384	1	[	[	X
admet-850	384	2	33	33	NUM
admet-850	384	3	]	]	X
admet-850	384	4	d.	d.	PROPN
admet-850	384	5	smith	smith	PROPN
admet-850	384	6	,	,	PUNCT
admet-850	384	7	e.	e.	PROPN
admet-850	384	8	lin	lin	PROPN
admet-850	384	9	,	,	PUNCT
admet-850	384	10	and	and	CCONJ
admet-850	384	11	l.	l.	PROPN
admet-850	384	12	benet	benet	PROPN
admet-850	384	13	.	.	PUNCT
admet-850	385	1	absorption	absorption	NOUN
admet-850	385	2	and	and	CCONJ
admet-850	385	3	disposition	disposition	NOUN
admet-850	385	4	of	of	ADP
admet-850	385	5	furosemide	furosemide	NOUN
admet-850	385	6	in	in	ADP
admet-850	385	7	healthy	healthy	ADJ
admet-850	385	8	volunteers	volunteer	NOUN
admet-850	385	9	,	,	PUNCT
admet-850	385	10	measured	measure	VERB
admet-850	385	11	with	with	ADP
admet-850	385	12	a	a	DET
admet-850	385	13	metabolite	metabolite	NOUN
admet-850	385	14	-	-	PUNCT
admet-850	385	15	specific	specific	NOUN
admet-850	385	16	assay	assay	NOUN
admet-850	385	17	.	.	PUNCT
admet-850	386	1	drug	drug	NOUN
admet-850	386	2	metab	metab	NOUN
admet-850	386	3	.	.	PUNCT
admet-850	387	1	dispos	dispos	PROPN
admet-850	387	2	.	.	PUNCT
admet-850	388	1	8	8	NUM
admet-850	388	2	(	(	PUNCT
admet-850	388	3	1980	1980	NUM
admet-850	388	4	)	)	PUNCT
admet-850	389	1	337–342	337–342	NUM
admet-850	389	2	.	.	PUNCT
admet-850	390	1	https://www.ncbi.nlm.nih.gov/pubmed/?term=6107232	https://www.ncbi.nlm.nih.gov/pubmed/?term=6107232	PROPN
admet-850	390	2	(	(	PUNCT
admet-850	390	3	accessed	access	VERB
admet-850	390	4	may	may	PROPN
admet-850	390	5	6	6	NUM
admet-850	390	6	,	,	PUNCT
admet-850	390	7	2020	2020	NUM
admet-850	390	8	)	)	PUNCT
admet-850	390	9	.	.	PUNCT
admet-850	391	1	[	[	X
admet-850	391	2	34	34	NUM
admet-850	391	3	]	]	X
admet-850	391	4	g.	g.	PROPN
admet-850	391	5	mihaly	mihaly	PROPN
admet-850	391	6	,	,	PUNCT
admet-850	391	7	s.	s.	PROPN
admet-850	391	8	ward	ward	PROPN
admet-850	391	9	,	,	PUNCT
admet-850	391	10	g.	g.	PROPN
admet-850	391	11	edwards	edwards	PROPN
admet-850	391	12	,	,	PUNCT
admet-850	391	13	d.	d.	PROPN
admet-850	391	14	nicholl	nicholl	PROPN
admet-850	391	15	,	,	PUNCT
admet-850	391	16	m.	m.	NOUN
admet-850	391	17	orme	orme	PROPN
admet-850	391	18	,	,	PUNCT
admet-850	391	19	and	and	CCONJ
admet-850	391	20	a.	a.	PROPN
admet-850	391	21	breckenridge	breckenridge	PROPN
admet-850	391	22	.	.	PUNCT
admet-850	392	1	pharmacokinetics	pharmacokinetic	NOUN
admet-850	392	2	of	of	ADP
admet-850	392	3	primaquine	primaquine	NOUN
admet-850	392	4	in	in	ADP
admet-850	392	5	man	man	NOUN
admet-850	392	6	.	.	PUNCT
admet-850	393	1	i.	i.	PROPN
admet-850	393	2	studies	study	NOUN
admet-850	393	3	of	of	ADP
admet-850	393	4	the	the	DET
admet-850	393	5	absolute	absolute	ADJ
admet-850	393	6	bioavailability	bioavailability	NOUN
admet-850	393	7	and	and	CCONJ
admet-850	393	8	effects	effect	NOUN
admet-850	393	9	of	of	ADP
admet-850	393	10	dose	dose	NOUN
admet-850	393	11	size	size	NOUN
admet-850	393	12	.	.	PUNCT
admet-850	394	1	br	br	PROPN
admet-850	394	2	.	.	PUNCT
admet-850	395	1	j.	j.	PROPN
admet-850	395	2	clin	clin	PROPN
admet-850	395	3	.	.	PUNCT
admet-850	396	1	pharmacol	pharmacol	PROPN
admet-850	396	2	.	.	PROPN
admet-850	397	1	19	19	NUM
admet-850	397	2	(	(	PUNCT
admet-850	397	3	1985	1985	NUM
admet-850	397	4	)	)	PUNCT
admet-850	398	1	745–750	745–750	NUM
admet-850	398	2	.	.	PUNCT
admet-850	398	3	doi	doi	NOUN
admet-850	398	4	:	:	PUNCT
admet-850	398	5	https://doi.org/10.1111/j.1365-2125.1985.tb02709.x	https://doi.org/10.1111/j.1365-2125.1985.tb02709.x	PROPN
admet-850	398	6	.	.	PUNCT
admet-850	399	1	[	[	X
admet-850	399	2	35	35	NUM
admet-850	399	3	]	]	X
admet-850	399	4	d.s	d.s	PROPN
admet-850	399	5	.	.	PROPN
admet-850	399	6	almond	almond	PROPN
admet-850	399	7	,	,	PUNCT
admet-850	399	8	i.s.f	i.s.f	ADJ
admet-850	399	9	.	.	PUNCT
admet-850	399	10	szwandt	szwandt	PROPN
admet-850	399	11	,	,	PUNCT
admet-850	399	12	g.	g.	PROPN
admet-850	399	13	edwards	edwards	PROPN
admet-850	399	14	,	,	PUNCT
admet-850	399	15	m.g	m.g	PROPN
admet-850	399	16	.	.	PROPN
admet-850	399	17	lee	lee	PROPN
admet-850	399	18	,	,	PUNCT
admet-850	399	19	and	and	CCONJ
admet-850	399	20	p.a	p.a	PROPN
admet-850	399	21	.	.	PROPN
admet-850	399	22	winstanley	winstanley	PROPN
admet-850	399	23	.	.	PUNCT
admet-850	400	1	disposition	disposition	NOUN
admet-850	400	2	of	of	ADP
admet-850	400	3	intravenous	intravenous	ADJ
admet-850	400	4	pyrimethamine	pyrimethamine	NOUN
admet-850	400	5	in	in	ADP
admet-850	400	6	healthy	healthy	ADJ
admet-850	400	7	volunteers	volunteer	NOUN
admet-850	400	8	.	.	PUNCT
admet-850	401	1	antimicrob	antimicrob	PROPN
admet-850	401	2	.	.	PUNCT
admet-850	402	1	agents	agents	PROPN
admet-850	402	2	chemother	chemother	PROPN
admet-850	402	3	.	.	PUNCT
admet-850	403	1	44	44	NUM
admet-850	403	2	(	(	PUNCT
admet-850	403	3	2000	2000	NUM
admet-850	403	4	)	)	PUNCT
admet-850	403	5	1691–1693	1691–1693	NUM
admet-850	403	6	.	.	PUNCT
admet-850	404	1	doi	doi	NOUN
admet-850	404	2	:	:	PUNCT
admet-850	404	3	https://doi.org/10.1128/aac.44.6.1691-1693.2000	https://doi.org/10.1128/aac.44.6.1691-1693.2000	PROPN
admet-850	404	4	.	.	PUNCT
admet-850	405	1	[	[	X
admet-850	405	2	36	36	NUM
admet-850	405	3	]	]	X
admet-850	405	4	d.m	d.m	PROPN
admet-850	405	5	.	.	PROPN
admet-850	405	6	brainard	brainard	PROPN
admet-850	405	7	,	,	PUNCT
admet-850	405	8	l.a	l.a	PROPN
admet-850	405	9	.	.	PROPN
admet-850	405	10	wenning	wenning	NOUN
admet-850	405	11	,	,	PUNCT
admet-850	405	12	j.a	j.a	PROPN
admet-850	405	13	.	.	PROPN
admet-850	405	14	stone	stone	PROPN
admet-850	405	15	,	,	PUNCT
admet-850	405	16	j.a	j.a	PROPN
admet-850	405	17	.	.	PROPN
admet-850	405	18	wagner	wagner	PROPN
admet-850	405	19	,	,	PUNCT
admet-850	405	20	and	and	CCONJ
admet-850	405	21	m.	m.	NOUN
admet-850	405	22	iwamoto	iwamoto	ADJ
admet-850	405	23	.	.	PUNCT
admet-850	406	1	clinical	clinical	ADJ
admet-850	406	2	pharmacology	pharmacology	NOUN
admet-850	406	3	profile	profile	NOUN
admet-850	406	4	of	of	ADP
admet-850	406	5	raltegravir	raltegravir	PROPN
admet-850	406	6	,	,	PUNCT
admet-850	406	7	an	an	DET
admet-850	406	8	hiv-1	hiv-1	ADV
admet-850	406	9	integrase	integrase	NOUN
admet-850	406	10	strand	strand	NOUN
admet-850	406	11	transfer	transfer	NOUN
admet-850	406	12	inhibitor	inhibitor	NOUN
admet-850	406	13	.	.	PUNCT
admet-850	407	1	j.	j.	PROPN
admet-850	407	2	clin	clin	PROPN
admet-850	407	3	.	.	PUNCT
admet-850	408	1	pharmacol	pharmacol	PROPN
admet-850	408	2	.	.	PUNCT
admet-850	409	1	51	51	NUM
admet-850	409	2	(	(	PUNCT
admet-850	409	3	2011	2011	NUM
admet-850	409	4	)	)	PUNCT
admet-850	409	5	1376–402	1376–402	NOUN
admet-850	409	6	.	.	PUNCT
admet-850	410	1	doi	doi	NOUN
admet-850	410	2	:	:	PUNCT
admet-850	410	3	https://doi.org/10.1177/0091270010387428	https://doi.org/10.1177/0091270010387428	NOUN
admet-850	410	4	.	.	PUNCT
admet-850	411	1	[	[	X
admet-850	411	2	37	37	NUM
admet-850	411	3	]	]	X
admet-850	411	4	u.	u.	NOUN
admet-850	411	5	loos	loos	PROPN
admet-850	411	6	,	,	PUNCT
admet-850	411	7	e.	e.	PROPN
admet-850	411	8	musch	musch	PROPN
admet-850	411	9	,	,	PUNCT
admet-850	411	10	j.c	j.c	PROPN
admet-850	411	11	.	.	PROPN
admet-850	411	12	jensen	jensen	PROPN
admet-850	411	13	,	,	PUNCT
admet-850	411	14	g.	g.	PROPN
admet-850	411	15	mikus	mikus	PROPN
admet-850	411	16	,	,	PUNCT
admet-850	411	17	h.k	h.k	PROPN
admet-850	411	18	.	.	PROPN
admet-850	411	19	schwabe	schwabe	NOUN
admet-850	411	20	,	,	PUNCT
admet-850	411	21	and	and	CCONJ
admet-850	411	22	m.	m.	PROPN
admet-850	411	23	eichelbaum	eichelbaum	PROPN
admet-850	411	24	.	.	PUNCT
admet-850	412	1	pharmacokinetics	pharmacokinetic	NOUN
admet-850	412	2	of	of	ADP
admet-850	412	3	oral	oral	ADJ
admet-850	412	4	and	and	CCONJ
admet-850	412	5	intravenous	intravenous	ADJ
admet-850	412	6	rifampicin	rifampicin	VERB
admet-850	412	7	during	during	ADP
admet-850	412	8	chronic	chronic	ADJ
admet-850	412	9	administration	administration	NOUN
admet-850	412	10	.	.	PUNCT
admet-850	413	1	klin	klin	PROPN
admet-850	413	2	.	.	PUNCT
admet-850	413	3	wochenschr	wochenschr	PROPN
admet-850	413	4	.	.	PROPN
admet-850	414	1	63	63	NUM
admet-850	414	2	(	(	PUNCT
admet-850	414	3	1985	1985	NUM
admet-850	414	4	)	)	PUNCT
admet-850	414	5	1205–1211	1205–1211	NUM
admet-850	414	6	.	.	PUNCT
admet-850	415	1	doi	doi	NOUN
admet-850	415	2	:	:	PUNCT
admet-850	415	3	https://doi.org/10.1007/bf01733779	https://doi.org/10.1007/bf01733779	X
admet-850	415	4	.	.	PUNCT
admet-850	416	1	[	[	X
admet-850	416	2	38	38	NUM
admet-850	416	3	]	]	PUNCT
admet-850	416	4	p.	p.	NOUN
admet-850	416	5	barditch	barditch	PROPN
admet-850	416	6	-	-	PUNCT
admet-850	416	7	crovo	crovo	PROPN
admet-850	416	8	,	,	PUNCT
admet-850	416	9	s.g	s.g	PROPN
admet-850	416	10	.	.	PROPN
admet-850	416	11	deeks	deek	NOUN
admet-850	416	12	,	,	PUNCT
admet-850	416	13	a.	a.	NOUN
admet-850	416	14	collier	collier	NOUN
admet-850	416	15	,	,	PUNCT
admet-850	416	16	s.	s.	PROPN
admet-850	416	17	safrin	safrin	PROPN
admet-850	416	18	,	,	PUNCT
admet-850	416	19	d.f	d.f	PROPN
admet-850	416	20	.	.	PROPN
admet-850	416	21	coakley	coakley	PROPN
admet-850	416	22	,	,	PUNCT
admet-850	416	23	m.	m.	NOUN
admet-850	416	24	miller	miller	PROPN
admet-850	416	25	,	,	PUNCT
admet-850	416	26	b.p	b.p	PROPN
admet-850	416	27	.	.	PROPN
admet-850	416	28	kearney	kearney	PROPN
admet-850	416	29	,	,	PUNCT
admet-850	416	30	r.l	r.l	PROPN
admet-850	416	31	.	.	PROPN
admet-850	416	32	coleman	coleman	PROPN
admet-850	416	33	,	,	PUNCT
admet-850	416	34	p.d	p.d	PROPN
admet-850	416	35	.	.	PROPN
admet-850	416	36	lamy	lamy	PROPN
admet-850	416	37	,	,	PUNCT
admet-850	416	38	j.o	j.o	PROPN
admet-850	416	39	.	.	PROPN
admet-850	416	40	kahn	kahn	PROPN
admet-850	416	41	,	,	PUNCT
admet-850	416	42	i.	i.	PROPN
admet-850	416	43	mcgowan	mcgowan	PROPN
admet-850	416	44	,	,	PUNCT
admet-850	416	45	and	and	CCONJ
admet-850	416	46	p.s	p.s	PROPN
admet-850	416	47	.	.	PROPN
admet-850	416	48	lietman	lietman	NOUN
admet-850	416	49	.	.	PUNCT
admet-850	417	1	phase	phase	NOUN
admet-850	417	2	i	i	PRON
admet-850	417	3	/	/	SYM
admet-850	417	4	ii	ii	PROPN
admet-850	417	5	trial	trial	NOUN
admet-850	417	6	of	of	ADP
admet-850	417	7	the	the	DET
admet-850	417	8	pharmacokinetics	pharmacokinetic	NOUN
admet-850	417	9	,	,	PUNCT
admet-850	417	10	safety	safety	NOUN
admet-850	417	11	,	,	PUNCT
admet-850	417	12	and	and	CCONJ
admet-850	417	13	antiretroviral	antiretroviral	ADJ
admet-850	417	14	activity	activity	NOUN
admet-850	417	15	of	of	ADP
admet-850	417	16	tenofovir	tenofovir	NOUN
admet-850	417	17	disoproxil	disoproxil	VERB
admet-850	417	18	fumarate	fumarate	NOUN
admet-850	417	19	in	in	ADP
admet-850	417	20	human	human	ADJ
admet-850	417	21	immunodeficiency	immunodeficiency	NOUN
admet-850	417	22	virus	virus	NOUN
admet-850	417	23	-	-	PUNCT
admet-850	417	24	infected	infect	VERB
admet-850	417	25	adults	adult	NOUN
admet-850	417	26	.	.	PUNCT
admet-850	418	1	antimicrob	antimicrob	ADJ
admet-850	418	2	.	.	PUNCT
admet-850	419	1	agents	agent	NOUN
admet-850	419	2	chemother	chemother	PROPN
admet-850	419	3	.	.	PUNCT
admet-850	420	1	45	45	NUM
admet-850	420	2	(	(	PUNCT
admet-850	420	3	2001	2001	NUM
admet-850	420	4	)	)	PUNCT
admet-850	420	5	2733–2739	2733–2739	NUM
admet-850	420	6	.	.	PUNCT
admet-850	421	1	doi	doi	NOUN
admet-850	421	2	:	:	PUNCT
admet-850	421	3	https://doi.org/10.1128/aac.45.10.2733-2739.2001	https://doi.org/10.1128/aac.45.10.2733-2739.2001	NOUN
admet-850	421	4	.	.	PUNCT
admet-850	422	1	[	[	X
admet-850	422	2	39	39	NUM
admet-850	422	3	]	]	PUNCT
admet-850	422	4	p.	p.	NOUN
admet-850	422	5	bransford	bransford	PROPN
admet-850	422	6	,	,	PUNCT
admet-850	422	7	j.	j.	PROPN
admet-850	422	8	cook	cook	PROPN
admet-850	422	9	,	,	PUNCT
admet-850	422	10	m.	m.	NOUN
admet-850	422	11	gupta	gupta	PROPN
admet-850	422	12	,	,	PUNCT
admet-850	422	13	s.	s.	PROPN
admet-850	422	14	haertter	haertter	PROPN
admet-850	422	15	,	,	PUNCT
admet-850	422	16	h.	h.	PROPN
admet-850	422	17	he	he	PROPN
admet-850	422	18	,	,	PUNCT
admet-850	422	19	r.	r.	PROPN
admet-850	422	20	ju	ju	PROPN
admet-850	422	21	,	,	PUNCT
admet-850	422	22	j.	j.	PROPN
admet-850	422	23	kanodia	kanodia	PROPN
admet-850	422	24	,	,	PUNCT
admet-850	422	25	h.	h.	PROPN
admet-850	422	26	lennernäs	lennernäs	PROPN
admet-850	422	27	,	,	PUNCT
admet-850	422	28	d.	d.	PROPN
admet-850	422	29	lindley	lindley	PROPN
admet-850	422	30	,	,	PUNCT
admet-850	422	31	j.e	j.e	PROPN
admet-850	422	32	.	.	PROPN
admet-850	422	33	polli	polli	PROPN
admet-850	422	34	,	,	PUNCT
admet-850	422	35	l.	l.	PROPN
admet-850	422	36	wenning	wenning	NOUN
admet-850	422	37	,	,	PUNCT
admet-850	422	38	and	and	CCONJ
admet-850	422	39	y.	y.	PROPN
admet-850	422	40	wu	wu	PROPN
admet-850	422	41	.	.	PUNCT
admet-850	423	1	ich	ich	PROPN
admet-850	423	2	m9	m9	PROPN
admet-850	423	3	guideline	guideline	NOUN
admet-850	423	4	in	in	ADP
admet-850	423	5	development	development	NOUN
admet-850	423	6	on	on	ADP
admet-850	423	7	biopharmaceutics	biopharmaceutics	NOUN
admet-850	423	8	classification	classification	NOUN
admet-850	423	9	system	system	NOUN
admet-850	423	10	-	-	PUNCT
admet-850	423	11	based	base	VERB
admet-850	423	12	biowaivers	biowaiver	NOUN
admet-850	423	13	:	:	PUNCT
admet-850	423	14	an	an	DET
admet-850	423	15	industrial	industrial	ADJ
admet-850	423	16	perspective	perspective	NOUN
admet-850	423	17	from	from	ADP
admet-850	423	18	the	the	DET
admet-850	423	19	iq	iq	PROPN
admet-850	423	20	consortium	consortium	NOUN
admet-850	423	21	.	.	PUNCT
admet-850	424	1	mol	mol	PROPN
admet-850	424	2	.	.	PUNCT
admet-850	424	3	pharm	pharm	PROPN
admet-850	424	4	.	.	PUNCT
admet-850	425	1	17	17	NUM
admet-850	425	2	(	(	PUNCT
admet-850	425	3	2020	2020	NUM
admet-850	425	4	)	)	PUNCT
admet-850	426	1	361–372	361–372	NUM
admet-850	426	2	.	.	PUNCT
admet-850	426	3	doi	doi	NOUN
admet-850	426	4	:	:	PUNCT
admet-850	426	5	https://doi.org/	https://doi.org/	NOUN
admet-850	426	6	10.1021	10.1021	NUM
admet-850	426	7	/	/	SYM
admet-850	426	8	acs.molpharmaceut.9b01062	acs.molpharmaceut.9b01062	NOUN
admet-850	426	9	.	.	PUNCT
admet-850	427	1	[	[	X
admet-850	427	2	40	40	NUM
admet-850	427	3	]	]	PUNCT
admet-850	427	4	e.	e.	PROPN
admet-850	427	5	sjögren	sjögren	PROPN
admet-850	427	6	,	,	PUNCT
admet-850	427	7	h.	h.	PROPN
admet-850	427	8	thörn	thörn	PROPN
admet-850	427	9	,	,	PUNCT
admet-850	427	10	and	and	CCONJ
admet-850	427	11	c.	c.	PROPN
admet-850	427	12	tannergren	tannergren	PROPN
admet-850	427	13	.	.	PUNCT
admet-850	428	1	in	in	ADP
admet-850	428	2	silico	silico	NOUN
admet-850	428	3	modeling	modeling	NOUN
admet-850	428	4	of	of	ADP
admet-850	428	5	gastrointestinal	gastrointestinal	ADJ
admet-850	428	6	drug	drug	NOUN
admet-850	428	7	absorption	absorption	NOUN
admet-850	428	8	:	:	PUNCT
admet-850	428	9	predictive	predictive	ADJ
admet-850	428	10	performance	performance	NOUN
admet-850	428	11	of	of	ADP
admet-850	428	12	three	three	NUM
admet-850	428	13	physiologically	physiologically	ADV
admet-850	428	14	based	base	VERB
admet-850	428	15	absorption	absorption	NOUN
admet-850	428	16	models	model	NOUN
admet-850	428	17	.	.	PUNCT
admet-850	429	1	mol	mol	X
admet-850	429	2	.	.	PUNCT
admet-850	429	3	pharm	pharm	PROPN
admet-850	429	4	.	.	PUNCT
admet-850	430	1	13	13	NUM
admet-850	430	2	(	(	PUNCT
admet-850	430	3	2016	2016	NUM
admet-850	430	4	)	)	PUNCT
admet-850	430	5	1763–1778	1763–1778	NUM
admet-850	430	6	.	.	PUNCT
admet-850	431	1	doi	doi	NOUN
admet-850	431	2	:	:	PUNCT
admet-850	431	3	https://doi.org/10.1021/acs.molpharmaceut.5b00861	https://doi.org/10.1021/acs.molpharmaceut.5b00861	NOUN
admet-850	431	4	.	.	PUNCT
admet-850	432	1	©	©	NOUN
admet-850	432	2	2021	2021	NUM
admet-850	432	3	by	by	ADP
admet-850	432	4	the	the	DET
admet-850	432	5	authors	author	NOUN
admet-850	432	6	;	;	PUNCT
admet-850	432	7	licensee	licensee	PROPN
admet-850	432	8	iapc	iapc	PROPN
admet-850	432	9	,	,	PUNCT
admet-850	432	10	zagreb	zagreb	PROPN
admet-850	432	11	,	,	PUNCT
admet-850	432	12	croatia	croatia	PROPN
admet-850	432	13	.	.	PUNCT
admet-850	433	1	this	this	DET
admet-850	433	2	article	article	NOUN
admet-850	433	3	is	be	AUX
admet-850	433	4	an	an	DET
admet-850	433	5	open	open	ADJ
admet-850	433	6	-	-	PUNCT
admet-850	433	7	access	access	NOUN
admet-850	433	8	article	article	NOUN
admet-850	433	9	distributed	distribute	VERB
admet-850	433	10	under	under	ADP
admet-850	433	11	the	the	DET
admet-850	433	12	terms	term	NOUN
admet-850	433	13	and	and	CCONJ
admet-850	433	14	conditions	condition	NOUN
admet-850	433	15	of	of	ADP
admet-850	433	16	the	the	DET
admet-850	433	17	creative	creative	ADJ
admet-850	433	18	commons	common	NOUN
admet-850	433	19	attribution	attribution	NOUN
admet-850	433	20	license	license	NOUN
admet-850	433	21	(	(	PUNCT
admet-850	433	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-850	433	23	)	)	PUNCT
admet-850	433	24	https://dx.doi.org/10.5599/admet.850	https://dx.doi.org/10.5599/admet.850	VERB
admet-850	434	1	https://doi.org/10.1177/106002808201601107	https://doi.org/10.1177/106002808201601107	CCONJ
admet-850	434	2	https://doi.org/10.1007/s40262-017-0624-3	https://doi.org/10.1007/s40262-017-0624-3	NUM
admet-850	434	3	https://doi.org/10.2147/hiv.s4842	https://doi.org/10.2147/hiv.s4842	VERB
admet-850	434	4	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=204790	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=204790	PROPN
admet-850	434	5	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=204790	https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&varapplno=204790	NOUN
admet-850	434	6	https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20972biopharm_review.pdf	https://www.accessdata.fda.gov/drugsatfda_docs/nda/98/20972biopharm_review.pdf	NOUN
admet-850	434	7	https://doi.org/10.1128/aac.01984-19	https://doi.org/10.1128/aac.01984-19	PROPN
admet-850	434	8	https://doi.org/10.1111/j.1365-2125.1985.tb02709.x	https://doi.org/10.1111/j.1365-2125.1985.tb02709.x	PROPN
admet-850	435	1	https://doi.org/10.1128/aac.44.6.1691-1693.2000	https://doi.org/10.1128/aac.44.6.1691-1693.2000	PROPN
admet-850	436	1	https://doi.org/10.1177/0091270010387428	https://doi.org/10.1177/0091270010387428	X
admet-850	437	1	https://doi.org/10.1007/bf01733779	https://doi.org/10.1007/bf01733779	X
admet-850	437	2	https://doi.org/10.1128/aac.45.10.2733-2739.2001	https://doi.org/10.1128/aac.45.10.2733-2739.2001	PROPN
admet-850	437	3	https://doi.org/%2010.1021/acs.molpharmaceut.9b01062	https://doi.org/%2010.1021/acs.molpharmaceut.9b01062	PRON
admet-850	437	4	https://doi.org/10.1021/acs.molpharmaceut.5b00861	https://doi.org/10.1021/acs.molpharmaceut.5b00861	PRON
admet-850	437	5	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN