id	sid	tid	token	lemma	pos
admet-854	1	1	molecular	molecular	ADJ
admet-854	1	2	docking	docking	NOUN
admet-854	1	3	investigation	investigation	NOUN
admet-854	1	4	of	of	ADP
admet-854	1	5	the	the	DET
admet-854	1	6	amantadine	amantadine	NOUN
admet-854	1	7	binding	bind	VERB
admet-854	1	8	to	to	ADP
admet-854	1	9	the	the	DET
admet-854	1	10	enzymes	enzyme	NOUN
admet-854	1	11	upregulated	upregulate	VERB
admet-854	1	12	or	or	CCONJ
admet-854	1	13	downregulated	downregulate	VERB
admet-854	1	14	in	in	ADP
admet-854	1	15	parkinson	parkinson	NOUN
admet-854	1	16	’s	’s	PART
admet-854	1	17	disease	disease	NOUN
admet-854	1	18	doi	doi	PROPN
admet-854	1	19	:	:	PUNCT
admet-854	1	20	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	1	21	149	149	NUM
admet-854	1	22	admet	admet	X
admet-854	1	23	&	&	CCONJ
admet-854	1	24	dmpk	dmpk	PROPN
admet-854	1	25	8(2	8(2	NUM
admet-854	1	26	)	)	PUNCT
admet-854	1	27	(	(	PUNCT
admet-854	1	28	2020	2020	NUM
admet-854	1	29	)	)	PUNCT
admet-854	1	30	149	149	NUM
admet-854	1	31	-	-	SYM
admet-854	1	32	175	175	NUM
admet-854	1	33	;	;	PUNCT
admet-854	1	34	doi	doi	NOUN
admet-854	1	35	:	:	PUNCT
admet-854	1	36	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	1	37	open	open	ADJ
admet-854	1	38	access	access	NOUN
admet-854	1	39	:	:	PUNCT
admet-854	1	40	issn	issn	PROPN
admet-854	1	41	:	:	PUNCT
admet-854	1	42	1848	1848	NUM
admet-854	1	43	-	-	SYM
admet-854	1	44	7718	7718	NUM
admet-854	1	45	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-854	1	46	original	original	ADJ
admet-854	1	47	scientific	scientific	ADJ
admet-854	1	48	paper	paper	NOUN
admet-854	1	49	molecular	molecular	ADJ
admet-854	1	50	docking	docking	NOUN
admet-854	1	51	investigation	investigation	NOUN
admet-854	1	52	of	of	ADP
admet-854	1	53	the	the	DET
admet-854	1	54	amantadine	amantadine	NOUN
admet-854	1	55	binding	bind	VERB
admet-854	1	56	to	to	ADP
admet-854	1	57	the	the	DET
admet-854	1	58	enzymes	enzyme	NOUN
admet-854	1	59	upregulated	upregulate	VERB
admet-854	1	60	or	or	CCONJ
admet-854	1	61	downregulated	downregulate	VERB
admet-854	1	62	in	in	ADP
admet-854	1	63	parkinson	parkinson	NOUN
admet-854	1	64	’s	’s	PART
admet-854	1	65	disease	disease	NOUN
admet-854	1	66	mihaela	mihaela	PROPN
admet-854	1	67	ileana	ileana	PROPN
admet-854	1	68	ionescu	ionescu	PROPN
admet-854	1	69	1,2	1,2	NUM
admet-854	1	70	1	1	NUM
admet-854	1	71	department	department	NOUN
admet-854	1	72	of	of	ADP
admet-854	1	73	microbiology	microbiology	NOUN
admet-854	1	74	,	,	PUNCT
admet-854	1	75	iuliu	iuliu	PROPN
admet-854	1	76	hațieganu	hațieganu	PROPN
admet-854	1	77	university	university	PROPN
admet-854	1	78	of	of	ADP
admet-854	1	79	medicine	medicine	NOUN
admet-854	1	80	and	and	CCONJ
admet-854	1	81	pharmacy	pharmacy	NOUN
admet-854	1	82	,	,	PUNCT
admet-854	1	83	6	6	NUM
admet-854	1	84	louis	louis	PROPN
admet-854	1	85	pasteur	pasteur	PROPN
admet-854	1	86	,	,	PUNCT
admet-854	1	87	400349	400349	NUM
admet-854	1	88	,	,	PUNCT
admet-854	1	89	clujnapoca	clujnapoca	NOUN
admet-854	1	90	,	,	PUNCT
admet-854	1	91	romania	romania	PROPN
admet-854	1	92	,	,	PUNCT
admet-854	1	93	mionescu@umfcluj.ro	mionescu@umfcluj.ro	X
admet-854	1	94	2	2	NUM
admet-854	1	95	department	department	NOUN
admet-854	1	96	of	of	ADP
admet-854	1	97	microbiology	microbiology	NOUN
admet-854	1	98	,	,	PUNCT
admet-854	1	99	county	county	NOUN
admet-854	1	100	emergency	emergency	NOUN
admet-854	1	101	clinical	clinical	ADJ
admet-854	1	102	hospital	hospital	NOUN
admet-854	1	103	,	,	PUNCT
admet-854	1	104	400006	400006	NUM
admet-854	1	105	,	,	PUNCT
admet-854	1	106	cluj	cluj	NOUN
admet-854	1	107	-	-	PUNCT
admet-854	1	108	napoca	napoca	NOUN
admet-854	1	109	,	,	PUNCT
admet-854	1	110	romania	romania	PROPN
admet-854	1	111	e	e	PROPN
admet-854	1	112	-	-	NOUN
admet-854	1	113	mail	mail	NOUN
admet-854	1	114	:	:	PUNCT
admet-854	1	115	mionescu@umfcluj.ro	mionescu@umfcluj.ro	NOUN
admet-854	1	116	;	;	PUNCT
admet-854	1	117	received	receive	VERB
admet-854	1	118	:	:	PUNCT
admet-854	1	119	may	may	AUX
admet-854	1	120	15	15	NUM
admet-854	1	121	,	,	PUNCT
admet-854	1	122	2020	2020	NUM
admet-854	1	123	;	;	PUNCT
admet-854	1	124	revised	revise	VERB
admet-854	1	125	:	:	PUNCT
admet-854	1	126	june	june	PROPN
admet-854	1	127	01	01	NUM
admet-854	1	128	,	,	PUNCT
admet-854	1	129	2020	2020	NUM
admet-854	1	130	;	;	PUNCT
admet-854	1	131	published	publish	VERB
admet-854	1	132	:	:	PUNCT
admet-854	1	133	june	june	PROPN
admet-854	1	134	15	15	NUM
admet-854	1	135	,	,	PUNCT
admet-854	1	136	2020	2020	NUM
admet-854	1	137	abstract	abstract	ADJ
admet-854	1	138	parkinson	parkinson	NOUN
admet-854	1	139	’s	’s	PART
admet-854	1	140	disease	disease	NOUN
admet-854	1	141	(	(	PUNCT
admet-854	1	142	pd	pd	NOUN
admet-854	1	143	)	)	PUNCT
admet-854	1	144	is	be	AUX
admet-854	1	145	a	a	DET
admet-854	1	146	progressive	progressive	ADJ
admet-854	1	147	neurodegenerative	neurodegenerative	ADJ
admet-854	1	148	disease	disease	NOUN
admet-854	1	149	.	.	PUNCT
admet-854	2	1	levodopa	levodopa	NOUN
admet-854	2	2	in	in	ADP
admet-854	2	3	combination	combination	NOUN
admet-854	2	4	with	with	ADP
admet-854	2	5	amantadine	amantadine	NOUN
admet-854	2	6	has	have	VERB
admet-854	2	7	a	a	DET
admet-854	2	8	demonstrated	demonstrate	VERB
admet-854	2	9	efficacy	efficacy	NOUN
admet-854	2	10	in	in	ADP
admet-854	2	11	motility	motility	NOUN
admet-854	2	12	impairment	impairment	NOUN
admet-854	2	13	.	.	PUNCT
admet-854	3	1	an	an	DET
admet-854	3	2	extensive	extensive	ADJ
admet-854	3	3	investigation	investigation	NOUN
admet-854	3	4	of	of	ADP
admet-854	3	5	some	some	DET
admet-854	3	6	enzymes	enzyme	NOUN
admet-854	3	7	described	describe	VERB
admet-854	3	8	to	to	PART
admet-854	3	9	be	be	AUX
admet-854	3	10	upregulated	upregulate	VERB
admet-854	3	11	or	or	CCONJ
admet-854	3	12	downregulated	downregulate	VERB
admet-854	3	13	in	in	ADP
admet-854	3	14	pd	pd	PROPN
admet-854	3	15	was	be	AUX
admet-854	3	16	made	make	VERB
admet-854	3	17	–	–	PUNCT
admet-854	3	18	adenylate	adenylate	ADJ
admet-854	3	19	kinase	kinase	NOUN
admet-854	3	20	(	(	PUNCT
admet-854	3	21	ak	ak	PROPN
admet-854	3	22	)	)	PUNCT
admet-854	3	23	,	,	PUNCT
admet-854	3	24	adenine	adenine	ADJ
admet-854	3	25	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	3	26	(	(	PUNCT
admet-854	3	27	aprt	aprt	PROPN
admet-854	3	28	)	)	PUNCT
admet-854	3	29	,	,	PUNCT
admet-854	3	30	ectonucleoside	ectonucleoside	ADJ
admet-854	3	31	triphosphate	triphosphate	NOUN
admet-854	3	32	diphosphohydrolase	diphosphohydrolase	NOUN
admet-854	3	33	1	1	NUM
admet-854	3	34	(	(	PUNCT
admet-854	3	35	entpd1	entpd1	NOUN
admet-854	3	36	)	)	PUNCT
admet-854	3	37	,	,	PUNCT
admet-854	3	38	nucleoside	nucleoside	NOUN
admet-854	3	39	-	-	PUNCT
admet-854	3	40	diphosphate	diphosphate	NOUN
admet-854	3	41	kinase	kinase	NOUN
admet-854	3	42	3	3	NUM
admet-854	3	43	(	(	PUNCT
admet-854	3	44	ndk3	ndk3	PROPN
admet-854	3	45	)	)	PUNCT
admet-854	3	46	,	,	PUNCT
admet-854	3	47	purine	purine	NOUN
admet-854	3	48	nucleoside	nucleoside	NOUN
admet-854	3	49	phosphorylase	phosphorylase	NOUN
admet-854	3	50	1	1	NUM
admet-854	3	51	(	(	PUNCT
admet-854	3	52	pnp1	pnp1	PROPN
admet-854	3	53	)	)	PUNCT
admet-854	3	54	,	,	PUNCT
admet-854	3	55	and	and	CCONJ
admet-854	3	56	ecto-5’nucleotidase	ecto-5’nucleotidase	PROPN
admet-854	3	57	(	(	PUNCT
admet-854	3	58	nt5e	nt5e	NOUN
admet-854	3	59	)	)	PUNCT
admet-854	3	60	.	.	PUNCT
admet-854	4	1	also	also	ADV
admet-854	4	2	,	,	PUNCT
admet-854	4	3	creatine	creatine	PROPN
admet-854	4	4	kinase	kinase	PROPN
admet-854	4	5	(	(	PUNCT
admet-854	4	6	ck	ck	PROPN
admet-854	4	7	)	)	PUNCT
admet-854	4	8	was	be	AUX
admet-854	4	9	included	include	VERB
admet-854	4	10	in	in	ADP
admet-854	4	11	the	the	DET
admet-854	4	12	study	study	NOUN
admet-854	4	13	because	because	SCONJ
admet-854	4	14	it	it	PRON
admet-854	4	15	is	be	AUX
admet-854	4	16	one	one	NUM
admet-854	4	17	of	of	ADP
admet-854	4	18	the	the	DET
admet-854	4	19	main	main	ADJ
admet-854	4	20	enzymes	enzyme	NOUN
admet-854	4	21	involved	involve	VERB
admet-854	4	22	in	in	ADP
admet-854	4	23	the	the	DET
admet-854	4	24	regulation	regulation	NOUN
admet-854	4	25	of	of	ADP
admet-854	4	26	the	the	DET
admet-854	4	27	nucleotide	nucleotide	ADJ
admet-854	4	28	ratio	ratio	NOUN
admet-854	4	29	in	in	ADP
admet-854	4	30	energy	energy	NOUN
admet-854	4	31	metabolism	metabolism	NOUN
admet-854	4	32	.	.	PUNCT
admet-854	5	1	to	to	ADP
admet-854	5	2	date	date	NOUN
admet-854	5	3	,	,	PUNCT
admet-854	5	4	there	there	PRON
admet-854	5	5	is	be	VERB
admet-854	5	6	no	no	DET
admet-854	5	7	proven	prove	VERB
admet-854	5	8	link	link	NOUN
admet-854	5	9	between	between	ADP
admet-854	5	10	amantadine	amantadine	NOUN
admet-854	5	11	treatment	treatment	NOUN
admet-854	5	12	of	of	ADP
admet-854	5	13	pd	pd	PROPN
admet-854	5	14	and	and	CCONJ
admet-854	5	15	these	these	DET
admet-854	5	16	enzymes	enzyme	NOUN
admet-854	5	17	.	.	PUNCT
admet-854	6	1	because	because	SCONJ
admet-854	6	2	there	there	PRON
admet-854	6	3	are	be	VERB
admet-854	6	4	many	many	ADJ
admet-854	6	5	aks	ak	NOUN
admet-854	6	6	isoforms	isoform	NOUN
admet-854	6	7	modified	modify	VERB
admet-854	6	8	in	in	ADP
admet-854	6	9	pd	pd	PROPN
admet-854	6	10	,	,	PUNCT
admet-854	6	11	the	the	DET
admet-854	6	12	ak	ak	PROPN
admet-854	6	13	was	be	AUX
admet-854	6	14	the	the	DET
admet-854	6	15	first	first	ADJ
admet-854	6	16	investigated	investigate	VERB
admet-854	6	17	.	.	PUNCT
admet-854	7	1	the	the	DET
admet-854	7	2	molecular	molecular	ADJ
admet-854	7	3	docking	docking	NOUN
admet-854	7	4	experiments	experiment	NOUN
admet-854	7	5	allow	allow	VERB
admet-854	7	6	the	the	DET
admet-854	7	7	analysis	analysis	NOUN
admet-854	7	8	of	of	ADP
admet-854	7	9	the	the	DET
admet-854	7	10	selective	selective	ADJ
admet-854	7	11	binding	binding	NOUN
admet-854	7	12	of	of	ADP
admet-854	7	13	amantadine	amantadine	NOUN
admet-854	7	14	–	–	PUNCT
admet-854	7	15	unionized	unionized	ADJ
admet-854	7	16	(	(	PUNCT
admet-854	7	17	with	with	ADP
admet-854	7	18	–	–	PUNCT
admet-854	7	19	nh2	nh2	NOUN
admet-854	7	20	group	group	NOUN
admet-854	7	21	)	)	PUNCT
admet-854	7	22	and	and	CCONJ
admet-854	7	23	ionized	ionized	ADJ
admet-854	7	24	form	form	NOUN
admet-854	7	25	(	(	PUNCT
admet-854	7	26	with	with	ADP
admet-854	7	27	–	–	PUNCT
admet-854	7	28	nh3	nh3	NOUN
admet-854	7	29	+	+	NUM
admet-854	7	30	group	group	NOUN
admet-854	7	31	)	)	PUNCT
admet-854	7	32	–	–	PUNCT
admet-854	7	33	to	to	ADP
admet-854	7	34	the	the	DET
admet-854	7	35	aks	ak	NOUN
admet-854	7	36	’	'	PUNCT
admet-854	7	37	isoforms	isoform	NOUN
admet-854	7	38	implicated	implicate	VERB
admet-854	7	39	in	in	ADP
admet-854	7	40	pd	pd	PROPN
admet-854	7	41	.	.	PUNCT
admet-854	8	1	using	use	VERB
admet-854	8	2	available	available	ADJ
admet-854	8	3	x	x	NOUN
admet-854	8	4	-	-	NOUN
admet-854	8	5	ray	ray	ADJ
admet-854	8	6	3d	3d	PROPN
admet-854	8	7	structures	structure	NOUN
admet-854	8	8	of	of	ADP
admet-854	8	9	human	human	ADJ
admet-854	8	10	aks	ak	NOUN
admet-854	8	11	in	in	ADP
admet-854	8	12	closed	closed	ADJ
admet-854	8	13	-	-	PUNCT
admet-854	8	14	conformation	conformation	NOUN
admet-854	8	15	,	,	PUNCT
admet-854	8	16	it	it	PRON
admet-854	8	17	was	be	AUX
admet-854	8	18	demonstrated	demonstrate	VERB
admet-854	8	19	that	that	SCONJ
admet-854	8	20	there	there	PRON
admet-854	8	21	are	be	VERB
admet-854	8	22	notable	notable	ADJ
admet-854	8	23	differences	difference	NOUN
admet-854	8	24	between	between	ADP
admet-854	8	25	the	the	DET
admet-854	8	26	interactions	interaction	NOUN
admet-854	8	27	of	of	ADP
admet-854	8	28	the	the	DET
admet-854	8	29	two	two	NUM
admet-854	8	30	forms	form	NOUN
admet-854	8	31	of	of	ADP
admet-854	8	32	amantadine	amantadine	NOUN
admet-854	8	33	for	for	ADP
admet-854	8	34	the	the	DET
admet-854	8	35	zebrafish	zebrafish	ADJ
admet-854	8	36	ak1	ak1	NOUN
admet-854	8	37	(	(	PUNCT
admet-854	8	38	5xz2	5xz2	NUM
admet-854	8	39	)	)	PUNCT
admet-854	8	40	,	,	PUNCT
admet-854	8	41	human	human	ADJ
admet-854	8	42	ak2	ak2	NOUN
admet-854	8	43	(	(	PUNCT
admet-854	8	44	2c9y	2c9y	NOUN
admet-854	8	45	)	)	PUNCT
admet-854	8	46	,	,	PUNCT
admet-854	8	47	human	human	ADJ
admet-854	8	48	ak5	ak5	NOUN
admet-854	8	49	(	(	PUNCT
admet-854	8	50	2bwj	2bwj	NUM
admet-854	8	51	)	)	PUNCT
admet-854	8	52	,	,	PUNCT
admet-854	8	53	and	and	CCONJ
admet-854	8	54	ak	ak	PROPN
admet-854	8	55	from	from	ADP
admet-854	8	56	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	8	57	.	.	PUNCT
admet-854	9	1	the	the	DET
admet-854	9	2	cytosolic	cytosolic	PROPN
admet-854	9	3	human	human	PROPN
admet-854	9	4	ak1	ak1	PROPN
admet-854	9	5	and	and	CCONJ
admet-854	9	6	human	human	ADJ
admet-854	9	7	ak2	ak2	NOUN
admet-854	9	8	mostly	mostly	ADV
admet-854	9	9	interact	interact	VERB
admet-854	9	10	with	with	ADP
admet-854	9	11	ionized	ionized	ADJ
admet-854	9	12	amantadine	amantadine	NOUN
admet-854	9	13	by	by	ADP
admet-854	9	14	amp	amp	NOUN
admet-854	9	15	binding	bind	VERB
admet-854	9	16	residues	residue	NOUN
admet-854	9	17	.	.	PUNCT
admet-854	10	1	the	the	DET
admet-854	10	2	human	human	ADJ
admet-854	10	3	ak5	ak5	NOUN
admet-854	10	4	interaction	interaction	NOUN
admet-854	10	5	with	with	ADP
admet-854	10	6	ionized	ionized	ADJ
admet-854	10	7	amantadine	amantadine	NOUN
admet-854	10	8	does	do	AUX
admet-854	10	9	not	not	PART
admet-854	10	10	involve	involve	VERB
admet-854	10	11	the	the	DET
admet-854	10	12	residues	residue	NOUN
admet-854	10	13	from	from	ADP
admet-854	10	14	the	the	DET
admet-854	10	15	catalytic	catalytic	ADJ
admet-854	10	16	site	site	NOUN
admet-854	10	17	.	.	PUNCT
admet-854	11	1	among	among	ADP
admet-854	11	2	other	other	ADJ
admet-854	11	3	enzymes	enzyme	NOUN
admet-854	11	4	tested	test	VERB
admet-854	11	5	in	in	ADP
admet-854	11	6	the	the	DET
admet-854	11	7	present	present	ADJ
admet-854	11	8	study	study	NOUN
admet-854	11	9	,	,	PUNCT
admet-854	11	10	aprt	aprt	PROPN
admet-854	11	11	revealed	reveal	VERB
admet-854	11	12	the	the	DET
admet-854	11	13	best	good	ADJ
admet-854	11	14	results	result	NOUN
admet-854	11	15	in	in	ADP
admet-854	11	16	respect	respect	NOUN
admet-854	11	17	of	of	ADP
admet-854	11	18	binding	bind	VERB
admet-854	11	19	amantadine	amantadine	ADJ
admet-854	11	20	ionized	ionize	VERB
admet-854	11	21	form	form	NOUN
admet-854	11	22	.	.	PUNCT
admet-854	12	1	the	the	DET
admet-854	12	2	results	result	NOUN
admet-854	12	3	offer	offer	VERB
admet-854	12	4	a	a	DET
admet-854	12	5	new	new	ADJ
admet-854	12	6	perspective	perspective	NOUN
admet-854	12	7	for	for	ADP
admet-854	12	8	further	further	ADJ
admet-854	12	9	investigation	investigation	NOUN
admet-854	12	10	of	of	ADP
admet-854	12	11	the	the	DET
admet-854	12	12	connections	connection	NOUN
admet-854	12	13	between	between	ADP
admet-854	12	14	amantadine	amantadine	NOUN
admet-854	12	15	treatment	treatment	NOUN
admet-854	12	16	of	of	ADP
admet-854	12	17	pd	pd	PROPN
admet-854	12	18	and	and	CCONJ
admet-854	12	19	some	some	DET
admet-854	12	20	enzymes	enzyme	NOUN
admet-854	12	21	involved	involve	VERB
admet-854	12	22	in	in	ADP
admet-854	12	23	purine	purine	NOUN
admet-854	12	24	metabolism	metabolism	NOUN
admet-854	12	25	.	.	PUNCT
admet-854	13	1	©	©	PROPN
admet-854	13	2	2020	2020	NUM
admet-854	13	3	by	by	ADP
admet-854	13	4	the	the	DET
admet-854	13	5	authors	author	NOUN
admet-854	13	6	.	.	PUNCT
admet-854	14	1	this	this	DET
admet-854	14	2	article	article	NOUN
admet-854	14	3	is	be	AUX
admet-854	14	4	an	an	DET
admet-854	14	5	open	open	ADJ
admet-854	14	6	-	-	PUNCT
admet-854	14	7	access	access	NOUN
admet-854	14	8	article	article	NOUN
admet-854	14	9	distributed	distribute	VERB
admet-854	14	10	under	under	ADP
admet-854	14	11	the	the	DET
admet-854	14	12	terms	term	NOUN
admet-854	14	13	and	and	CCONJ
admet-854	14	14	conditions	condition	NOUN
admet-854	14	15	of	of	ADP
admet-854	14	16	the	the	DET
admet-854	14	17	creative	creative	ADJ
admet-854	14	18	commons	common	NOUN
admet-854	14	19	attribution	attribution	NOUN
admet-854	14	20	license	license	NOUN
admet-854	14	21	(	(	PUNCT
admet-854	14	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-854	14	23	)	)	PUNCT
admet-854	14	24	.	.	PUNCT
admet-854	15	1	keywords	keyword	VERB
admet-854	15	2	human	human	ADJ
admet-854	15	3	adenylate	adenylate	ADJ
admet-854	15	4	kinases	kinase	NOUN
admet-854	15	5	;	;	PUNCT
admet-854	15	6	adenine	adenine	ADJ
admet-854	15	7	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	15	8	;	;	PUNCT
admet-854	15	9	adenine	adenine	VERB
admet-854	15	10	metabolism	metabolism	NOUN
admet-854	15	11	;	;	PUNCT
admet-854	15	12	purine	purine	NOUN
admet-854	15	13	metabolism	metabolism	NOUN
admet-854	15	14	introduction	introduction	NOUN
admet-854	15	15	parkinson	parkinson	NOUN
admet-854	15	16	’s	’s	PART
admet-854	15	17	disease	disease	NOUN
admet-854	15	18	(	(	PUNCT
admet-854	15	19	pd	pd	NOUN
admet-854	15	20	)	)	PUNCT
admet-854	15	21	is	be	AUX
admet-854	15	22	an	an	DET
admet-854	15	23	idiopathic	idiopathic	ADJ
admet-854	15	24	neurodegenerative	neurodegenerative	ADJ
admet-854	15	25	and	and	CCONJ
admet-854	15	26	progressive	progressive	ADJ
admet-854	15	27	disease	disease	NOUN
admet-854	15	28	,	,	PUNCT
admet-854	15	29	which	which	PRON
admet-854	15	30	mainly	mainly	ADV
admet-854	15	31	produces	produce	VERB
admet-854	15	32	motility	motility	NOUN
admet-854	15	33	impairment	impairment	NOUN
admet-854	15	34	with	with	ADP
admet-854	15	35	bradykinesia	bradykinesia	PROPN
admet-854	15	36	,	,	PUNCT
admet-854	15	37	tremor	tremor	NOUN
admet-854	15	38	,	,	PUNCT
admet-854	15	39	and	and	CCONJ
admet-854	15	40	postural	postural	ADJ
admet-854	15	41	instability	instability	NOUN
admet-854	15	42	[	[	X
admet-854	15	43	1,2	1,2	NUM
admet-854	15	44	]	]	PUNCT
admet-854	15	45	.	.	PUNCT
admet-854	16	1	in	in	ADP
admet-854	16	2	pd	pd	PROPN
admet-854	16	3	,	,	PUNCT
admet-854	16	4	the	the	DET
admet-854	16	5	neurotransmitter	neurotransmitter	NOUN
admet-854	16	6	dopamine	dopamine	NOUN
admet-854	16	7	is	be	AUX
admet-854	16	8	reduced	reduce	VERB
admet-854	16	9	as	as	ADP
admet-854	16	10	a	a	DET
admet-854	16	11	result	result	NOUN
admet-854	16	12	of	of	ADP
admet-854	16	13	the	the	DET
admet-854	16	14	degeneration	degeneration	NOUN
admet-854	16	15	of	of	ADP
admet-854	16	16	the	the	DET
admet-854	16	17	dopaminergic	dopaminergic	ADJ
admet-854	16	18	neurons	neuron	NOUN
admet-854	16	19	from	from	ADP
admet-854	16	20	the	the	DET
admet-854	16	21	substantia	substantia	NOUN
admet-854	16	22	nigra	nigra	NOUN
admet-854	17	1	[	[	X
admet-854	17	2	3	3	NUM
admet-854	17	3	]	]	PUNCT
admet-854	17	4	.	.	PUNCT
admet-854	18	1	the	the	DET
admet-854	18	2	pd	pd	ADJ
admet-854	18	3	-	-	PUNCT
admet-854	18	4	related	relate	VERB
admet-854	18	5	drug	drug	NOUN
admet-854	18	6	utilization	utilization	NOUN
admet-854	18	7	and	and	CCONJ
admet-854	18	8	pd	pd	NOUN
admet-854	18	9	-	-	PUNCT
admet-854	18	10	related	relate	VERB
admet-854	18	11	other	other	ADJ
admet-854	18	12	degenerative	degenerative	ADJ
admet-854	18	13	diseases	disease	NOUN
admet-854	18	14	are	be	AUX
admet-854	18	15	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	18	16	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	18	17	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-854	18	18	mailto:mionescu@umfcluj.ro	mailto:mionescu@umfcluj.ro	VERB
admet-854	18	19	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-854	18	20	mihaela	mihaela	PROPN
admet-854	18	21	ileana	ileana	PROPN
admet-854	18	22	ionescu	ionescu	PROPN
admet-854	18	23	admet	admet	PROPN
admet-854	18	24	&	&	CCONJ
admet-854	18	25	dmpk	dmpk	PROPN
admet-854	18	26	8(2	8(2	NUM
admet-854	18	27	)	)	PUNCT
admet-854	18	28	(	(	PUNCT
admet-854	18	29	2020	2020	NUM
admet-854	18	30	)	)	PUNCT
admet-854	18	31	149	149	NUM
admet-854	18	32	-	-	SYM
admet-854	18	33	175	175	NUM
admet-854	18	34	150	150	NUM
admet-854	18	35	due	due	ADP
admet-854	18	36	to	to	ADP
admet-854	18	37	the	the	DET
admet-854	18	38	losses	loss	NOUN
admet-854	18	39	/	/	SYM
admet-854	18	40	impairment	impairment	NOUN
admet-854	18	41	of	of	ADP
admet-854	18	42	the	the	DET
admet-854	18	43	dopamine	dopamine	NOUN
admet-854	18	44	action	action	NOUN
admet-854	18	45	at	at	ADP
admet-854	18	46	the	the	DET
admet-854	18	47	basal	basal	ADJ
admet-854	18	48	ganglions	ganglion	NOUN
admet-854	18	49	[	[	X
admet-854	18	50	4,5	4,5	NUM
admet-854	18	51	]	]	PUNCT
admet-854	18	52	.	.	PUNCT
admet-854	19	1	also	also	ADV
admet-854	19	2	,	,	PUNCT
admet-854	19	3	some	some	DET
admet-854	19	4	toxins	toxin	NOUN
admet-854	19	5	(	(	PUNCT
admet-854	19	6	6hydroxydopamine	6hydroxydopamine	NUM
admet-854	19	7	)	)	PUNCT
admet-854	19	8	are	be	AUX
admet-854	19	9	identified	identify	VERB
admet-854	19	10	to	to	PART
admet-854	19	11	induce	induce	VERB
admet-854	19	12	dopaminergic	dopaminergic	ADJ
admet-854	19	13	cell	cell	NOUN
admet-854	19	14	death	death	NOUN
admet-854	20	1	[	[	X
admet-854	20	2	6–8	6–8	X
admet-854	20	3	]	]	X
admet-854	20	4	.	.	PUNCT
admet-854	21	1	pd	pd	PROPN
admet-854	21	2	is	be	AUX
admet-854	21	3	a	a	DET
admet-854	21	4	chronic	chronic	ADJ
admet-854	21	5	disease	disease	NOUN
admet-854	21	6	with	with	ADP
admet-854	21	7	no	no	DET
admet-854	21	8	curative	curative	ADJ
admet-854	21	9	treatment	treatment	NOUN
admet-854	21	10	of	of	ADP
admet-854	21	11	the	the	DET
admet-854	21	12	underline	underline	ADJ
admet-854	21	13	disease	disease	NOUN
admet-854	21	14	.	.	PUNCT
admet-854	22	1	therefore	therefore	ADV
admet-854	22	2	is	be	AUX
admet-854	22	3	an	an	DET
admet-854	22	4	ongoing	ongoing	ADJ
admet-854	22	5	interest	interest	NOUN
admet-854	22	6	in	in	ADP
admet-854	22	7	founding	found	VERB
admet-854	22	8	the	the	DET
admet-854	22	9	most	most	ADV
admet-854	22	10	efficient	efficient	ADJ
admet-854	22	11	strategy	strategy	NOUN
admet-854	22	12	for	for	ADP
admet-854	22	13	treatment	treatment	NOUN
admet-854	22	14	the	the	DET
admet-854	22	15	motility	motility	NOUN
admet-854	22	16	disorders	disorder	NOUN
admet-854	22	17	and	and	CCONJ
admet-854	22	18	other	other	ADJ
admet-854	22	19	symptoms	symptom	NOUN
admet-854	22	20	[	[	X
admet-854	22	21	9–14	9–14	X
admet-854	22	22	]	]	X
admet-854	22	23	.	.	PUNCT
admet-854	23	1	the	the	DET
admet-854	23	2	drugs	drug	NOUN
admet-854	23	3	used	use	VERB
admet-854	23	4	in	in	ADP
admet-854	23	5	the	the	DET
admet-854	23	6	treatment	treatment	NOUN
admet-854	23	7	of	of	ADP
admet-854	23	8	pd	pd	PROPN
admet-854	23	9	should	should	AUX
admet-854	23	10	correct	correct	VERB
admet-854	23	11	the	the	DET
admet-854	23	12	dopamine	dopamine	NOUN
admet-854	23	13	/	/	SYM
admet-854	23	14	cholinergic	cholinergic	NOUN
admet-854	23	15	balance	balance	NOUN
admet-854	23	16	,	,	PUNCT
admet-854	23	17	because	because	SCONJ
admet-854	23	18	the	the	DET
admet-854	23	19	level	level	NOUN
admet-854	23	20	of	of	ADP
admet-854	23	21	dopamine	dopamine	NOUN
admet-854	23	22	in	in	ADP
admet-854	23	23	the	the	DET
admet-854	23	24	caudateputamen	caudateputaman	NOUN
admet-854	23	25	in	in	ADP
admet-854	23	26	the	the	DET
admet-854	23	27	striatum	striatum	NOUN
admet-854	23	28	is	be	AUX
admet-854	23	29	considerably	considerably	ADV
admet-854	23	30	reduced	reduce	VERB
admet-854	23	31	,	,	PUNCT
admet-854	23	32	with	with	ADP
admet-854	23	33	the	the	DET
admet-854	23	34	exacerbation	exacerbation	NOUN
admet-854	23	35	of	of	ADP
admet-854	23	36	the	the	DET
admet-854	23	37	cholinergic	cholinergic	ADJ
admet-854	23	38	control	control	NOUN
admet-854	24	1	[	[	X
admet-854	24	2	15,16	15,16	NUM
admet-854	24	3	]	]	PUNCT
admet-854	24	4	.	.	PUNCT
admet-854	25	1	the	the	DET
admet-854	25	2	most	most	ADV
admet-854	25	3	used	used	ADJ
admet-854	25	4	dopaminergic	dopaminergic	ADJ
admet-854	25	5	drugs	drug	NOUN
admet-854	25	6	are	be	AUX
admet-854	25	7	levodopa	levodopa	NOUN
admet-854	25	8	,	,	PUNCT
admet-854	25	9	bromocriptine	bromocriptine	NOUN
admet-854	25	10	,	,	PUNCT
admet-854	25	11	and	and	CCONJ
admet-854	25	12	amantadine	amantadine	NOUN
admet-854	25	13	whereas	whereas	SCONJ
admet-854	25	14	the	the	DET
admet-854	25	15	main	main	ADJ
admet-854	25	16	anticholinergic	anticholinergic	ADJ
admet-854	25	17	drug	drug	NOUN
admet-854	25	18	is	be	AUX
admet-854	25	19	trihexyphenidyl	trihexyphenidyl	ADJ
admet-854	26	1	[	[	X
admet-854	26	2	17–20	17–20	NUM
admet-854	26	3	]	]	X
admet-854	26	4	.	.	PUNCT
admet-854	27	1	levodopa	levodopa	NOUN
admet-854	27	2	,	,	PUNCT
admet-854	27	3	discovered	discover	VERB
admet-854	27	4	in	in	ADP
admet-854	27	5	1950	1950	NUM
admet-854	27	6	,	,	PUNCT
admet-854	27	7	was	be	AUX
admet-854	27	8	first	first	ADV
admet-854	27	9	approved	approve	VERB
admet-854	27	10	in	in	ADP
admet-854	27	11	pd	pd	PROPN
admet-854	27	12	treatment	treatment	NOUN
admet-854	27	13	by	by	ADP
admet-854	27	14	the	the	DET
admet-854	27	15	fda	fda	PROPN
admet-854	27	16	(	(	PUNCT
admet-854	27	17	u.s	u.s	PROPN
admet-854	27	18	.	.	PROPN
admet-854	27	19	food	food	PROPN
admet-854	27	20	and	and	CCONJ
admet-854	27	21	drug	drug	NOUN
admet-854	27	22	administration	administration	NOUN
admet-854	27	23	)	)	PUNCT
admet-854	27	24	in	in	ADP
admet-854	27	25	1975	1975	NUM
admet-854	27	26	in	in	ADP
admet-854	27	27	combination	combination	NOUN
admet-854	27	28	with	with	ADP
admet-854	27	29	carbidopa	carbidopa	NOUN
admet-854	27	30	,	,	PUNCT
admet-854	27	31	on	on	ADP
admet-854	27	32	the	the	DET
admet-854	27	33	product	product	NOUN
admet-854	27	34	called	call	VERB
admet-854	27	35	sinemet	sinemet	PROPN
admet-854	28	1	[	[	X
admet-854	28	2	21	21	NUM
admet-854	28	3	]	]	PUNCT
admet-854	28	4	.	.	PUNCT
admet-854	29	1	an	an	DET
admet-854	29	2	important	important	ADJ
admet-854	29	3	side	side	NOUN
admet-854	29	4	effect	effect	NOUN
admet-854	29	5	of	of	ADP
admet-854	29	6	long	long	ADJ
admet-854	29	7	-	-	PUNCT
admet-854	29	8	term	term	NOUN
admet-854	29	9	use	use	NOUN
admet-854	29	10	of	of	ADP
admet-854	29	11	levodopa	levodopa	NOUN
admet-854	29	12	is	be	AUX
admet-854	29	13	levodopa	levodopa	NOUN
admet-854	29	14	-	-	PUNCT
admet-854	29	15	induced	induce	VERB
admet-854	29	16	dyskinesia	dyskinesia	NOUN
admet-854	30	1	[	[	X
admet-854	30	2	22	22	NUM
admet-854	30	3	]	]	PUNCT
admet-854	30	4	.	.	PUNCT
admet-854	31	1	in	in	ADP
admet-854	31	2	this	this	DET
admet-854	31	3	case	case	NOUN
admet-854	31	4	,	,	PUNCT
admet-854	31	5	amantadine	amantadine	NOUN
admet-854	31	6	is	be	AUX
admet-854	31	7	the	the	DET
admet-854	31	8	only	only	ADJ
admet-854	31	9	treatment	treatment	NOUN
admet-854	31	10	option	option	NOUN
admet-854	31	11	that	that	PRON
admet-854	31	12	has	have	AUX
admet-854	31	13	been	be	AUX
admet-854	31	14	shown	show	VERB
admet-854	31	15	to	to	PART
admet-854	31	16	be	be	AUX
admet-854	31	17	effective	effective	ADJ
admet-854	31	18	[	[	X
admet-854	31	19	23	23	NUM
admet-854	31	20	]	]	PUNCT
admet-854	31	21	.	.	PUNCT
admet-854	32	1	according	accord	VERB
admet-854	32	2	to	to	ADP
admet-854	32	3	drugbank	drugbank	NOUN
admet-854	32	4	(	(	PUNCT
admet-854	32	5	https://www.drugbank.ca/	https://www.drugbank.ca/	NUM
admet-854	32	6	)	)	PUNCT
admet-854	32	7	,	,	PUNCT
admet-854	32	8	amantadine	amantadine	NOUN
admet-854	32	9	(	(	PUNCT
admet-854	32	10	accession	accession	NOUN
admet-854	32	11	number	number	NOUN
admet-854	32	12	db00915	db00915	NOUN
admet-854	32	13	)	)	PUNCT
admet-854	32	14	is	be	AUX
admet-854	32	15	not	not	PART
admet-854	32	16	only	only	ADV
admet-854	32	17	an	an	DET
admet-854	32	18	antiviral	antiviral	NOUN
admet-854	32	19	used	use	VERB
admet-854	32	20	for	for	ADP
admet-854	32	21	prophylaxis	prophylaxis	NOUN
admet-854	32	22	and	and	CCONJ
admet-854	32	23	treatment	treatment	NOUN
admet-854	32	24	in	in	ADP
admet-854	32	25	infections	infection	NOUN
admet-854	32	26	with	with	ADP
admet-854	32	27	influenza	influenza	NOUN
admet-854	32	28	a	a	PRON
admet-854	32	29	but	but	CCONJ
admet-854	32	30	,	,	PUNCT
admet-854	32	31	also	also	ADV
admet-854	32	32	an	an	DET
admet-854	32	33	effective	effective	ADJ
admet-854	32	34	antiparkinsonian	antiparkinsonian	NOUN
admet-854	32	35	in	in	ADP
admet-854	32	36	combination	combination	NOUN
admet-854	32	37	with	with	ADP
admet-854	32	38	levodopa	levodopa	NOUN
admet-854	32	39	.	.	PUNCT
admet-854	33	1	the	the	DET
admet-854	33	2	mechanism	mechanism	NOUN
admet-854	33	3	of	of	ADP
admet-854	33	4	action	action	NOUN
admet-854	33	5	of	of	ADP
admet-854	33	6	amantadine	amantadine	NOUN
admet-854	33	7	is	be	AUX
admet-854	33	8	not	not	PART
admet-854	33	9	entirely	entirely	ADV
admet-854	33	10	understood	understand	VERB
admet-854	33	11	.	.	PUNCT
admet-854	34	1	according	accord	VERB
admet-854	34	2	to	to	ADP
admet-854	34	3	pubchem	pubchem	NOUN
admet-854	34	4	(	(	PUNCT
admet-854	34	5	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
admet-854	34	6	)	)	PUNCT
admet-854	34	7	,	,	PUNCT
admet-854	34	8	amantadine	amantadine	NOUN
admet-854	34	9	(	(	PUNCT
admet-854	34	10	pubchem	pubchem	NOUN
admet-854	34	11	cid	cid	NOUN
admet-854	34	12	2130	2130	NUM
admet-854	34	13	)	)	PUNCT
admet-854	34	14	stimulates	stimulate	VERB
admet-854	34	15	the	the	DET
admet-854	34	16	release	release	NOUN
admet-854	34	17	of	of	ADP
admet-854	34	18	dopamine	dopamine	NOUN
admet-854	34	19	from	from	ADP
admet-854	34	20	striatal	striatal	ADJ
admet-854	34	21	dopaminergic	dopaminergic	ADJ
admet-854	34	22	nerve	nerve	NOUN
admet-854	34	23	terminals	terminal	NOUN
admet-854	34	24	and	and	CCONJ
admet-854	34	25	inhibits	inhibit	VERB
admet-854	34	26	the	the	DET
admet-854	34	27	pre	pre	ADJ
admet-854	34	28	-	-	ADJ
admet-854	34	29	synaptic	synaptic	ADJ
admet-854	34	30	uptake	uptake	NOUN
admet-854	34	31	of	of	ADP
admet-854	34	32	dopamine	dopamine	NOUN
admet-854	34	33	.	.	PUNCT
admet-854	35	1	in	in	ADP
admet-854	35	2	neurodegenerative	neurodegenerative	ADJ
admet-854	35	3	diseases	disease	NOUN
admet-854	35	4	,	,	PUNCT
admet-854	35	5	among	among	ADP
admet-854	35	6	other	other	ADJ
admet-854	35	7	biomarkers	biomarker	NOUN
admet-854	35	8	,	,	PUNCT
admet-854	35	9	some	some	DET
admet-854	35	10	aks	ak	NOUN
admet-854	35	11	isoforms	isoform	NOUN
admet-854	35	12	are	be	AUX
admet-854	35	13	dysregulated	dysregulate	VERB
admet-854	35	14	.	.	PUNCT
admet-854	36	1	there	there	PRON
admet-854	36	2	is	be	VERB
admet-854	36	3	demonstrated	demonstrate	VERB
admet-854	36	4	that	that	SCONJ
admet-854	36	5	in	in	ADP
admet-854	36	6	stages	stage	NOUN
admet-854	36	7	3	3	NUM
admet-854	36	8	-	-	SYM
admet-854	36	9	6	6	NUM
admet-854	36	10	of	of	ADP
admet-854	36	11	the	the	DET
admet-854	36	12	pd	pd	NOUN
admet-854	36	13	there	there	PRON
admet-854	36	14	is	be	VERB
admet-854	36	15	a	a	DET
admet-854	36	16	down	down	ADJ
admet-854	36	17	-	-	PUNCT
admet-854	36	18	regulation	regulation	NOUN
admet-854	36	19	of	of	ADP
admet-854	36	20	the	the	DET
admet-854	36	21	ak2	ak2	NOUN
admet-854	36	22	,	,	PUNCT
admet-854	36	23	ak3	ak3	NOUN
admet-854	36	24	and	and	CCONJ
admet-854	36	25	ak4	ak4	NOUN
admet-854	36	26	in	in	ADP
admet-854	36	27	the	the	DET
admet-854	36	28	substantia	substantia	NOUN
admet-854	36	29	nigra	nigra	NOUN
admet-854	36	30	.	.	PUNCT
admet-854	37	1	also	also	ADV
admet-854	37	2	,	,	PUNCT
admet-854	37	3	there	there	PRON
admet-854	37	4	is	be	VERB
admet-854	37	5	a	a	DET
admet-854	37	6	reduced	reduced	ADJ
admet-854	37	7	expression	expression	NOUN
admet-854	37	8	of	of	ADP
admet-854	37	9	adenine	adenine	ADJ
admet-854	37	10	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	37	11	(	(	PUNCT
admet-854	37	12	aprt	aprt	NOUN
admet-854	37	13	)	)	PUNCT
admet-854	37	14	,	,	PUNCT
admet-854	37	15	ectonucleoside	ectonucleoside	ADJ
admet-854	37	16	triphosphate	triphosphate	VERB
admet-854	37	17	diphosphorylase	diphosphorylase	NOUN
admet-854	37	18	1	1	NUM
admet-854	37	19	(	(	PUNCT
admet-854	37	20	entpd1	entpd1	NOUN
admet-854	37	21	)	)	PUNCT
admet-854	37	22	,	,	PUNCT
admet-854	37	23	nucleoside	nucleoside	NOUN
admet-854	37	24	-	-	PUNCT
admet-854	37	25	diphosphate	diphosphate	NOUN
admet-854	37	26	kinase	kinase	NOUN
admet-854	37	27	3	3	NUM
admet-854	37	28	(	(	PUNCT
admet-854	37	29	ndk3	ndk3	PROPN
admet-854	37	30	)	)	PUNCT
admet-854	37	31	and	and	CCONJ
admet-854	37	32	purine	purine	NOUN
admet-854	37	33	nucleosise	nucleosise	NOUN
admet-854	37	34	phosphorylase	phosphorylase	NOUN
admet-854	37	35	1	1	NUM
admet-854	37	36	(	(	PUNCT
admet-854	37	37	pnp1	pnp1	PROPN
admet-854	37	38	)	)	PUNCT
admet-854	37	39	mrna	mrna	PROPN
admet-854	37	40	.	.	PUNCT
admet-854	38	1	on	on	ADP
admet-854	38	2	contrary	contrary	PROPN
admet-854	38	3	,	,	PUNCT
admet-854	38	4	the	the	DET
admet-854	38	5	stages	stage	NOUN
admet-854	38	6	5	5	NUM
admet-854	38	7	-	-	SYM
admet-854	38	8	6	6	NUM
admet-854	38	9	of	of	ADP
admet-854	38	10	pd	pd	PROPN
admet-854	38	11	are	be	AUX
admet-854	38	12	characterized	characterize	VERB
admet-854	38	13	by	by	ADP
admet-854	38	14	the	the	DET
admet-854	38	15	up	up	NOUN
admet-854	38	16	-	-	PUNCT
admet-854	38	17	regulation	regulation	NOUN
admet-854	38	18	of	of	ADP
admet-854	38	19	the	the	DET
admet-854	38	20	ak1	ak1	NOUN
admet-854	38	21	,	,	PUNCT
admet-854	38	22	ak5	ak5	NOUN
admet-854	38	23	,	,	PUNCT
admet-854	38	24	nucleoside	nucleoside	NOUN
admet-854	38	25	-	-	PUNCT
admet-854	38	26	diphosphate	diphosphate	NOUN
admet-854	38	27	kinase	kinase	NOUN
admet-854	38	28	5	5	NUM
admet-854	38	29	(	(	PUNCT
admet-854	38	30	ndk5	ndk5	PROPN
admet-854	38	31	)	)	PUNCT
admet-854	38	32	,	,	PUNCT
admet-854	39	1	ecto-5’-nucleotidase	ecto-5’-nucleotidase	PROPN
admet-854	39	2	(	(	PUNCT
admet-854	39	3	nt5e	nt5e	NOUN
admet-854	39	4	)	)	PUNCT
admet-854	39	5	and	and	CCONJ
admet-854	39	6	purine	purine	NOUN
admet-854	39	7	nucleoside	nucleoside	NOUN
admet-854	39	8	phosphorylase	phosphorylase	NOUN
admet-854	39	9	1(pnp1	1(pnp1	NUM
admet-854	39	10	)	)	PUNCT
admet-854	40	1	[	[	X
admet-854	40	2	24	24	NUM
admet-854	40	3	]	]	PUNCT
admet-854	40	4	.	.	PUNCT
admet-854	41	1	as	as	ADP
admet-854	41	2	the	the	DET
admet-854	41	3	changes	change	NOUN
admet-854	41	4	in	in	ADP
admet-854	41	5	the	the	DET
admet-854	41	6	purine	purine	NOUN
admet-854	41	7	metabolism	metabolism	NOUN
admet-854	41	8	influence	influence	NOUN
admet-854	41	9	the	the	DET
admet-854	41	10	evolution	evolution	NOUN
admet-854	41	11	of	of	ADP
admet-854	41	12	pd	pd	PROPN
admet-854	41	13	and	and	CCONJ
admet-854	41	14	,	,	PUNCT
admet-854	41	15	ultimately	ultimately	ADV
admet-854	41	16	,	,	PUNCT
admet-854	41	17	the	the	DET
admet-854	41	18	effectiveness	effectiveness	NOUN
admet-854	41	19	of	of	ADP
admet-854	41	20	the	the	DET
admet-854	41	21	treatment	treatment	NOUN
admet-854	41	22	,	,	PUNCT
admet-854	41	23	the	the	DET
admet-854	41	24	study	study	NOUN
admet-854	41	25	of	of	ADP
admet-854	41	26	human	human	ADJ
admet-854	41	27	aks	ak	NOUN
admet-854	41	28	isoforms	isoform	NOUN
admet-854	41	29	and	and	CCONJ
admet-854	41	30	enzymes	enzyme	NOUN
admet-854	41	31	involved	involve	VERB
admet-854	41	32	in	in	ADP
admet-854	41	33	the	the	DET
admet-854	41	34	purine	purine	NOUN
admet-854	41	35	metabolism	metabolism	NOUN
admet-854	41	36	is	be	AUX
admet-854	41	37	of	of	ADP
admet-854	41	38	great	great	ADJ
admet-854	41	39	interest	interest	NOUN
admet-854	41	40	.	.	PUNCT
admet-854	42	1	the	the	DET
admet-854	42	2	present	present	ADJ
admet-854	42	3	study	study	NOUN
admet-854	42	4	aimed	aim	VERB
admet-854	42	5	to	to	PART
admet-854	42	6	analyze	analyze	VERB
admet-854	42	7	the	the	DET
admet-854	42	8	connection	connection	NOUN
admet-854	42	9	between	between	ADP
admet-854	42	10	the	the	DET
admet-854	42	11	dysregulated	dysregulated	ADJ
admet-854	42	12	enzymes	enzyme	NOUN
admet-854	42	13	in	in	ADP
admet-854	42	14	different	different	ADJ
admet-854	42	15	stages	stage	NOUN
admet-854	42	16	of	of	ADP
admet-854	42	17	pd	pd	NOUN
admet-854	42	18	and	and	CCONJ
admet-854	42	19	amantadine	amantadine	NOUN
admet-854	42	20	.	.	PUNCT
admet-854	43	1	it	it	PRON
admet-854	43	2	is	be	AUX
admet-854	43	3	noteworthy	noteworthy	ADJ
admet-854	43	4	that	that	SCONJ
admet-854	43	5	different	different	ADJ
admet-854	43	6	aks	ak	NOUN
admet-854	43	7	isoforms	isoform	NOUN
admet-854	43	8	are	be	AUX
admet-854	43	9	modified	modify	VERB
admet-854	43	10	in	in	ADP
admet-854	43	11	pd	pd	PROPN
admet-854	43	12	.	.	PUNCT
admet-854	44	1	the	the	DET
admet-854	44	2	elements	element	NOUN
admet-854	44	3	that	that	PRON
admet-854	44	4	link	link	VERB
admet-854	44	5	the	the	DET
admet-854	44	6	ak1	ak1	NOUN
admet-854	44	7	and	and	CCONJ
admet-854	44	8	ak2	ak2	NOUN
admet-854	44	9	isoforms	isoform	NOUN
admet-854	44	10	and	and	CCONJ
admet-854	44	11	amantadine	amantadine	NOUN
admet-854	44	12	are	be	AUX
admet-854	44	13	dyskinesia	dyskinesia	ADJ
admet-854	44	14	and	and	CCONJ
admet-854	44	15	inflammation	inflammation	NOUN
admet-854	44	16	.	.	PUNCT
admet-854	45	1	ak1	ak1	NOUN
admet-854	45	2	and	and	CCONJ
admet-854	45	3	ak2	ak2	NOUN
admet-854	45	4	isoforms	isoform	NOUN
admet-854	45	5	are	be	AUX
admet-854	45	6	altered	alter	VERB
admet-854	45	7	in	in	ADP
admet-854	45	8	other	other	ADJ
admet-854	45	9	muscle	muscle	NOUN
admet-854	45	10	diseases	disease	NOUN
admet-854	45	11	–	–	PUNCT
admet-854	45	12	duchenne	duchenne	VERB
admet-854	45	13	muscular	muscular	ADJ
admet-854	45	14	dystrophy	dystrophy	NOUN
admet-854	45	15	–	–	PUNCT
admet-854	45	16	or	or	CCONJ
admet-854	45	17	in	in	ADP
admet-854	45	18	intense	intense	ADJ
admet-854	45	19	physical	physical	ADJ
admet-854	45	20	activity	activity	NOUN
admet-854	45	21	[	[	X
admet-854	45	22	25–30	25–30	NUM
admet-854	45	23	]	]	PUNCT
admet-854	45	24	.	.	PUNCT
admet-854	46	1	it	it	PRON
admet-854	46	2	has	have	AUX
admet-854	46	3	long	long	ADV
admet-854	46	4	been	be	AUX
admet-854	46	5	known	know	VERB
admet-854	46	6	,	,	PUNCT
admet-854	46	7	on	on	ADP
admet-854	46	8	the	the	DET
admet-854	46	9	one	one	NUM
admet-854	46	10	hand	hand	NOUN
admet-854	46	11	,	,	PUNCT
admet-854	46	12	the	the	DET
admet-854	46	13	positive	positive	ADJ
admet-854	46	14	role	role	NOUN
admet-854	46	15	or	or	CCONJ
admet-854	46	16	amantadine	amantadine	NOUN
admet-854	46	17	in	in	ADP
admet-854	46	18	managing	manage	VERB
admet-854	46	19	dyskinesia	dyskinesia	NOUN
admet-854	46	20	from	from	ADP
admet-854	46	21	pd	pd	PROPN
admet-854	46	22	and	and	CCONJ
admet-854	46	23	,	,	PUNCT
admet-854	46	24	on	on	ADP
admet-854	46	25	the	the	DET
admet-854	46	26	other	other	ADJ
admet-854	46	27	hand	hand	NOUN
admet-854	46	28	,	,	PUNCT
admet-854	46	29	the	the	DET
admet-854	46	30	ak1	ak1	NOUN
admet-854	46	31	and	and	CCONJ
admet-854	46	32	ak2	ak2	NOUN
admet-854	46	33	dysregulation	dysregulation	NOUN
admet-854	46	34	in	in	ADP
admet-854	46	35	pd	pd	PROPN
admet-854	46	36	.	.	PUNCT
admet-854	47	1	however	however	ADV
admet-854	47	2	,	,	PUNCT
admet-854	47	3	to	to	ADP
admet-854	47	4	date	date	NOUN
admet-854	47	5	,	,	PUNCT
admet-854	47	6	there	there	PRON
admet-854	47	7	is	be	VERB
admet-854	47	8	no	no	DET
admet-854	47	9	proven	prove	VERB
admet-854	47	10	link	link	NOUN
admet-854	47	11	between	between	ADP
admet-854	47	12	amantadine	amantadine	NOUN
admet-854	47	13	and	and	CCONJ
admet-854	47	14	ak	ak	PROPN
admet-854	47	15	in	in	ADP
admet-854	47	16	pd	pd	PROPN
admet-854	47	17	.	.	PROPN
admet-854	48	1	before	before	ADP
admet-854	48	2	planning	plan	VERB
admet-854	48	3	a	a	DET
admet-854	48	4	strategy	strategy	NOUN
admet-854	48	5	that	that	PRON
admet-854	48	6	implies	imply	VERB
admet-854	48	7	costly	costly	ADJ
admet-854	48	8	and	and	CCONJ
admet-854	48	9	time	time	NOUN
admet-854	48	10	-	-	PUNCT
admet-854	48	11	consuming	consume	VERB
admet-854	48	12	experiments	experiment	NOUN
admet-854	48	13	,	,	PUNCT
admet-854	48	14	the	the	DET
admet-854	48	15	molecular	molecular	ADJ
admet-854	48	16	docking	docking	NOUN
admet-854	48	17	experiments	experiment	NOUN
admet-854	48	18	were	be	AUX
admet-854	48	19	chosen	choose	VERB
admet-854	48	20	to	to	PART
admet-854	48	21	perform	perform	VERB
admet-854	48	22	the	the	DET
admet-854	48	23	present	present	ADJ
admet-854	48	24	study	study	NOUN
admet-854	48	25	.	.	PUNCT
admet-854	49	1	the	the	DET
admet-854	49	2	ak	ak	PROPN
admet-854	49	3	was	be	AUX
admet-854	49	4	the	the	DET
admet-854	49	5	first	first	ADJ
admet-854	49	6	enzyme	enzyme	NOUN
admet-854	49	7	analyzed	analyze	VERB
admet-854	49	8	because	because	SCONJ
admet-854	49	9	the	the	DET
admet-854	49	10	specific	specific	ADJ
admet-854	49	11	conformational	conformational	ADJ
admet-854	49	12	movements	movement	NOUN
admet-854	49	13	of	of	ADP
admet-854	49	14	the	the	DET
admet-854	49	15	aks	ak	NOUN
admet-854	49	16	during	during	ADP
admet-854	49	17	catalysis	catalysis	NOUN
admet-854	49	18	are	be	AUX
admet-854	49	19	well	well	ADV
admet-854	49	20	studied	study	VERB
admet-854	49	21	and	and	CCONJ
admet-854	49	22	there	there	PRON
admet-854	49	23	are	be	VERB
admet-854	49	24	many	many	ADJ
admet-854	49	25	x	x	ADJ
admet-854	49	26	-	-	NOUN
admet-854	49	27	ray	ray	ADJ
admet-854	49	28	3d	3d	NOUN
admet-854	49	29	structures	structure	NOUN
admet-854	49	30	of	of	ADP
admet-854	49	31	these	these	DET
admet-854	49	32	conformations	conformation	NOUN
admet-854	49	33	of	of	ADP
admet-854	49	34	the	the	DET
admet-854	49	35	aks	ak	NOUN
admet-854	49	36	deposed	depose	VERB
admet-854	49	37	in	in	ADP
admet-854	49	38	the	the	DET
admet-854	49	39	protein	protein	NOUN
admet-854	49	40	data	data	PROPN
admet-854	49	41	bank	bank	PROPN
admet-854	49	42	(	(	PUNCT
admet-854	49	43	pdb	pdb	PROPN
admet-854	49	44	)	)	PUNCT
admet-854	49	45	.	.	PUNCT
admet-854	50	1	therefore	therefore	ADV
admet-854	50	2	,	,	PUNCT
admet-854	50	3	molecular	molecular	ADJ
admet-854	50	4	docking	docking	NOUN
admet-854	50	5	,	,	PUNCT
admet-854	50	6	despite	despite	SCONJ
admet-854	50	7	the	the	DET
admet-854	50	8	limitations	limitation	NOUN
admet-854	50	9	of	of	ADP
admet-854	50	10	the	the	DET
admet-854	50	11	method	method	NOUN
admet-854	50	12	,	,	PUNCT
admet-854	50	13	allows	allow	VERB
admet-854	50	14	a	a	DET
admet-854	50	15	first	first	ADJ
admet-854	50	16	look	look	NOUN
admet-854	50	17	at	at	ADP
admet-854	50	18	the	the	DET
admet-854	50	19	connection	connection	NOUN
admet-854	50	20	between	between	ADP
admet-854	50	21	pd	pd	PROPN
admet-854	50	22	,	,	PUNCT
admet-854	50	23	amantadine	amantadine	NOUN
admet-854	50	24	,	,	PUNCT
admet-854	50	25	and	and	CCONJ
admet-854	50	26	some	some	DET
admet-854	50	27	enzymes	enzyme	NOUN
admet-854	50	28	already	already	ADV
admet-854	50	29	demonstrated	demonstrate	VERB
admet-854	50	30	to	to	PART
admet-854	50	31	be	be	AUX
admet-854	50	32	dysregulated	dysregulate	VERB
admet-854	50	33	in	in	ADP
admet-854	50	34	pd	pd	PROPN
admet-854	50	35	.	.	PUNCT
admet-854	51	1	we	we	PRON
admet-854	51	2	analyzed	analyze	VERB
admet-854	51	3	the	the	DET
admet-854	51	4	amantadine	amantadine	ADJ
admet-854	51	5	ionized	ionize	VERB
admet-854	51	6	form	form	NOUN
admet-854	51	7	(	(	PUNCT
admet-854	51	8	with	with	ADP
admet-854	51	9	–	–	PUNCT
admet-854	51	10	nh3	nh3	NOUN
admet-854	51	11	+	+	NUM
admet-854	51	12	group	group	NOUN
admet-854	51	13	)	)	PUNCT
admet-854	51	14	because	because	SCONJ
admet-854	51	15	the	the	DET
admet-854	51	16	amantadine	amantadine	NOUN
admet-854	51	17	is	be	AUX
admet-854	51	18	ionized	ionize	VERB
admet-854	51	19	in	in	ADP
admet-854	51	20	physiological	physiological	ADJ
admet-854	51	21	conditions	condition	NOUN
admet-854	51	22	[	[	X
admet-854	51	23	31	31	NUM
admet-854	51	24	]	]	PUNCT
admet-854	51	25	.	.	PUNCT
admet-854	52	1	to	to	PART
admet-854	52	2	verify	verify	VERB
admet-854	52	3	the	the	DET
admet-854	52	4	hypothesis	hypothesis	NOUN
admet-854	52	5	of	of	ADP
admet-854	52	6	that	that	DET
admet-854	52	7	amantadine	amantadine	NOUN
admet-854	52	8	specifically	specifically	ADV
admet-854	52	9	target	target	VERB
admet-854	52	10	some	some	DET
admet-854	52	11	enzymes	enzyme	NOUN
admet-854	52	12	modified	modify	VERB
admet-854	52	13	in	in	ADP
admet-854	52	14	pd	pd	PROPN
admet-854	52	15	,	,	PUNCT
admet-854	52	16	the	the	DET
admet-854	52	17	https://www.drugbank.ca/	https://www.drugbank.ca/	NUM
admet-854	52	18	https://pubchem.ncbi.nlm.nih.gov/	https://pubchem.ncbi.nlm.nih.gov/	PROPN
admet-854	52	19	admet	admet	PROPN
admet-854	52	20	&	&	CCONJ
admet-854	52	21	dmpk	dmpk	PROPN
admet-854	52	22	8(2	8(2	NUM
admet-854	52	23	)	)	PUNCT
admet-854	52	24	(	(	PUNCT
admet-854	52	25	2020	2020	NUM
admet-854	52	26	)	)	PUNCT
admet-854	52	27	149	149	NUM
admet-854	52	28	-	-	SYM
admet-854	52	29	175	175	NUM
admet-854	52	30	amantadine	amantadine	NOUN
admet-854	52	31	binding	bind	VERB
admet-854	52	32	to	to	ADP
admet-854	52	33	the	the	DET
admet-854	52	34	enzymes	enzyme	NOUN
admet-854	52	35	regulated	regulate	VERB
admet-854	52	36	in	in	ADP
admet-854	52	37	parkinson	parkinson	NOUN
admet-854	52	38	’s	’s	PART
admet-854	52	39	disease	disease	NOUN
admet-854	52	40	doi	doi	PROPN
admet-854	52	41	:	:	PUNCT
admet-854	52	42	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	52	43	151	151	NUM
admet-854	52	44	following	follow	VERB
admet-854	52	45	enzymes	enzyme	NOUN
admet-854	52	46	were	be	AUX
admet-854	52	47	analyzed	analyze	VERB
admet-854	52	48	–	–	PUNCT
admet-854	52	49	adenylate	adenylate	ADJ
admet-854	52	50	kinase	kinase	NOUN
admet-854	52	51	(	(	PUNCT
admet-854	52	52	ak	ak	PROPN
admet-854	52	53	)	)	PUNCT
admet-854	52	54	,	,	PUNCT
admet-854	52	55	adenine	adenine	ADJ
admet-854	52	56	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	52	57	(	(	PUNCT
admet-854	52	58	aprt	aprt	PROPN
admet-854	52	59	)	)	PUNCT
admet-854	52	60	,	,	PUNCT
admet-854	52	61	ectonucleoside	ectonucleoside	ADJ
admet-854	52	62	triphosphate	triphosphate	NOUN
admet-854	52	63	diphosphohydrolase	diphosphohydrolase	NOUN
admet-854	52	64	1	1	NUM
admet-854	52	65	(	(	PUNCT
admet-854	52	66	entpd1	entpd1	NOUN
admet-854	52	67	)	)	PUNCT
admet-854	52	68	,	,	PUNCT
admet-854	52	69	nucleoside	nucleoside	NOUN
admet-854	52	70	-	-	PUNCT
admet-854	52	71	diphosphate	diphosphate	NOUN
admet-854	52	72	kinase	kinase	NOUN
admet-854	52	73	3	3	NUM
admet-854	52	74	(	(	PUNCT
admet-854	52	75	ndk3	ndk3	PROPN
admet-854	52	76	)	)	PUNCT
admet-854	52	77	,	,	PUNCT
admet-854	52	78	purine	purine	NOUN
admet-854	52	79	nucleoside	nucleoside	NOUN
admet-854	52	80	phosphorylase	phosphorylase	NOUN
admet-854	52	81	1	1	NUM
admet-854	52	82	(	(	PUNCT
admet-854	52	83	pnp1	pnp1	PROPN
admet-854	52	84	)	)	PUNCT
admet-854	52	85	,	,	PUNCT
admet-854	52	86	and	and	CCONJ
admet-854	52	87	ecto-5’-nucleotidase	ecto-5’-nucleotidase	PROPN
admet-854	52	88	(	(	PUNCT
admet-854	52	89	nt5e	nt5e	NOUN
admet-854	52	90	)	)	PUNCT
admet-854	52	91	.	.	PUNCT
admet-854	53	1	more	more	ADJ
admet-854	53	2	,	,	PUNCT
admet-854	53	3	because	because	SCONJ
admet-854	53	4	in	in	ADP
admet-854	53	5	skeletal	skeletal	ADJ
admet-854	53	6	muscle	muscle	NOUN
admet-854	53	7	ak1	ak1	NOUN
admet-854	53	8	and	and	CCONJ
admet-854	53	9	creatinine	creatinine	PROPN
admet-854	53	10	kinase	kinase	PROPN
admet-854	53	11	(	(	PUNCT
admet-854	53	12	ck	ck	PROPN
admet-854	53	13	)	)	PUNCT
admet-854	53	14	are	be	AUX
admet-854	53	15	the	the	DET
admet-854	53	16	main	main	ADJ
admet-854	53	17	enzymes	enzyme	NOUN
admet-854	53	18	involved	involve	VERB
admet-854	53	19	in	in	ADP
admet-854	53	20	the	the	DET
admet-854	53	21	regulation	regulation	NOUN
admet-854	53	22	of	of	ADP
admet-854	53	23	nucleotide	nucleotide	ADJ
admet-854	53	24	ratio	ratio	NOUN
admet-854	53	25	in	in	ADP
admet-854	53	26	energy	energy	NOUN
admet-854	53	27	metabolism	metabolism	NOUN
admet-854	53	28	,	,	PUNCT
admet-854	53	29	the	the	DET
admet-854	53	30	molecular	molecular	ADJ
admet-854	53	31	docking	docking	NOUN
admet-854	53	32	of	of	ADP
admet-854	53	33	ck	ck	PROPN
admet-854	53	34	was	be	AUX
admet-854	53	35	an	an	DET
admet-854	53	36	additional	additional	ADJ
admet-854	53	37	analysis	analysis	NOUN
admet-854	53	38	[	[	X
admet-854	53	39	27	27	NUM
admet-854	53	40	]	]	PUNCT
admet-854	53	41	.	.	PUNCT
admet-854	54	1	experimental	experimental	ADJ
admet-854	54	2	the	the	DET
admet-854	54	3	study	study	NOUN
admet-854	54	4	workflow	workflow	NOUN
admet-854	54	5	is	be	AUX
admet-854	54	6	as	as	SCONJ
admet-854	54	7	follows	follow	VERB
admet-854	54	8	:	:	PUNCT
admet-854	54	9	(	(	PUNCT
admet-854	54	10	1	1	X
admet-854	54	11	)	)	PUNCT
admet-854	54	12	retrieving	retrieve	VERB
admet-854	54	13	and	and	CCONJ
admet-854	54	14	analysis	analysis	NOUN
admet-854	54	15	of	of	ADP
admet-854	54	16	the	the	DET
admet-854	54	17	enzymes	enzyme	NOUN
admet-854	54	18	with	with	ADP
admet-854	54	19	x	x	NOUN
admet-854	54	20	-	-	NOUN
admet-854	54	21	ray	ray	ADJ
admet-854	54	22	3d	3d	NOUN
admet-854	54	23	crystalline	crystalline	NOUN
admet-854	54	24	structure	structure	NOUN
admet-854	54	25	deposed	depose	VERB
admet-854	54	26	in	in	ADP
admet-854	54	27	public	public	ADJ
admet-854	54	28	databases	database	NOUN
admet-854	54	29	,	,	PUNCT
admet-854	54	30	(	(	PUNCT
admet-854	54	31	2	2	X
admet-854	54	32	)	)	PUNCT
admet-854	54	33	molecular	molecular	ADJ
admet-854	54	34	docking	docking	NOUN
admet-854	54	35	procedure	procedure	NOUN
admet-854	54	36	with	with	ADP
admet-854	54	37	amantadine	amantadine	NOUN
admet-854	54	38	ionized	ionize	VERB
admet-854	54	39	form	form	NOUN
admet-854	54	40	(	(	PUNCT
admet-854	54	41	with	with	ADP
admet-854	54	42	–	–	PUNCT
admet-854	54	43	nh3	nh3	NOUN
admet-854	54	44	+	+	NUM
admet-854	54	45	group	group	NOUN
admet-854	54	46	)	)	PUNCT
admet-854	54	47	,	,	PUNCT
admet-854	54	48	(	(	PUNCT
admet-854	54	49	3	3	X
admet-854	54	50	)	)	PUNCT
admet-854	54	51	redocking	redocking	NOUN
admet-854	54	52	of	of	ADP
admet-854	54	53	the	the	DET
admet-854	54	54	substrates	substrate	NOUN
admet-854	54	55	/	/	SYM
admet-854	54	56	substrates	substrate	NOUN
admet-854	54	57	analogs	analog	NOUN
admet-854	54	58	with	with	ADP
admet-854	54	59	aks	ak	NOUN
admet-854	54	60	,	,	PUNCT
admet-854	54	61	(	(	PUNCT
admet-854	54	62	4	4	X
admet-854	54	63	)	)	PUNCT
admet-854	54	64	multiple	multiple	ADJ
admet-854	54	65	sequences	sequence	NOUN
admet-854	54	66	alignment	alignment	NOUN
admet-854	54	67	of	of	ADP
admet-854	54	68	aks	ak	NOUN
admet-854	54	69	,	,	PUNCT
admet-854	54	70	(	(	PUNCT
admet-854	54	71	5	5	X
admet-854	54	72	)	)	PUNCT
admet-854	54	73	retrieving	retrieve	VERB
admet-854	54	74	and	and	CCONJ
admet-854	54	75	analysis	analysis	NOUN
admet-854	54	76	of	of	ADP
admet-854	54	77	the	the	DET
admet-854	54	78	aprt	aprt	NOUN
admet-854	54	79	,	,	PUNCT
admet-854	54	80	entpd1	entpd1	PROPN
admet-854	54	81	,	,	PUNCT
admet-854	54	82	ndk3	ndk3	PROPN
admet-854	54	83	,	,	PUNCT
admet-854	54	84	pnp1	pnp1	PROPN
admet-854	54	85	,	,	PUNCT
admet-854	54	86	nt5e	nt5e	PROPN
admet-854	54	87	,	,	PUNCT
admet-854	54	88	and	and	CCONJ
admet-854	54	89	ck	ck	INTJ
admet-854	54	90	with	with	ADP
admet-854	54	91	x	x	NOUN
admet-854	54	92	-	-	NOUN
admet-854	54	93	ray	ray	ADJ
admet-854	54	94	3d	3d	NOUN
admet-854	54	95	crystalline	crystalline	NOUN
admet-854	54	96	structure	structure	NOUN
admet-854	54	97	deposed	depose	VERB
admet-854	54	98	in	in	ADP
admet-854	54	99	public	public	ADJ
admet-854	54	100	databases	database	NOUN
admet-854	54	101	,	,	PUNCT
admet-854	54	102	(	(	PUNCT
admet-854	54	103	6	6	X
admet-854	54	104	)	)	PUNCT
admet-854	54	105	molecular	molecular	ADJ
admet-854	54	106	docking	docking	NOUN
admet-854	54	107	procedure	procedure	NOUN
admet-854	54	108	with	with	ADP
admet-854	54	109	amantadine	amantadine	NOUN
admet-854	54	110	ionized	ionize	VERB
admet-854	54	111	form	form	NOUN
admet-854	54	112	(	(	PUNCT
admet-854	54	113	with	with	ADP
admet-854	54	114	–	–	PUNCT
admet-854	54	115	nh3	nh3	NOUN
admet-854	54	116	+	+	NUM
admet-854	54	117	group	group	NOUN
admet-854	54	118	)	)	PUNCT
admet-854	54	119	of	of	ADP
admet-854	54	120	the	the	DET
admet-854	54	121	following	follow	VERB
admet-854	54	122	enzymes	enzyme	NOUN
admet-854	54	123	:	:	PUNCT
admet-854	54	124	aprt	aprt	NOUN
admet-854	54	125	,	,	PUNCT
admet-854	54	126	entpd1	entpd1	PROPN
admet-854	54	127	,	,	PUNCT
admet-854	54	128	ndk3	ndk3	PROPN
admet-854	54	129	,	,	PUNCT
admet-854	54	130	pnp1	pnp1	PROPN
admet-854	54	131	,	,	PUNCT
admet-854	54	132	nt5e	nt5e	PROPN
admet-854	54	133	,	,	PUNCT
admet-854	54	134	and	and	CCONJ
admet-854	54	135	ck	ck	PROPN
admet-854	54	136	.	.	PUNCT
admet-854	54	137	adenylate	adenylate	ADJ
admet-854	54	138	kinase	kinase	NOUN
admet-854	54	139	(	(	PUNCT
admet-854	54	140	ak	ak	PROPN
admet-854	54	141	)	)	PUNCT
admet-854	54	142	the	the	DET
admet-854	54	143	human	human	ADJ
admet-854	54	144	aks	ak	NOUN
admet-854	54	145	isoforms	isoform	NOUN
admet-854	54	146	and	and	CCONJ
admet-854	54	147	selected	select	VERB
admet-854	54	148	other	other	ADJ
admet-854	54	149	aks	ak	NOUN
admet-854	54	150	from	from	ADP
admet-854	54	151	other	other	ADJ
admet-854	54	152	organisms	organism	NOUN
admet-854	54	153	were	be	AUX
admet-854	54	154	retrieved	retrieve	VERB
admet-854	54	155	from	from	ADP
admet-854	54	156	the	the	DET
admet-854	54	157	pdb	pdb	PROPN
admet-854	54	158	(	(	PUNCT
admet-854	54	159	https://www.rcsb.org/	https://www.rcsb.org/	NOUN
admet-854	54	160	)	)	PUNCT
admet-854	54	161	.	.	PUNCT
admet-854	55	1	the	the	DET
admet-854	55	2	characteristics	characteristic	NOUN
admet-854	55	3	of	of	ADP
admet-854	55	4	the	the	DET
admet-854	55	5	aks	ak	NOUN
admet-854	55	6	tested	test	VERB
admet-854	55	7	(	(	PUNCT
admet-854	55	8	pdb	pdb	NOUN
admet-854	55	9	id(s	id(s	PUNCT
admet-854	55	10	)	)	PUNCT
admet-854	55	11	2c95	2c95	ADV
admet-854	55	12	,	,	PUNCT
admet-854	55	13	1z83	1z83	NOUN
admet-854	55	14	,	,	PUNCT
admet-854	55	15	5xz2	5xz2	NUM
admet-854	55	16	,	,	PUNCT
admet-854	55	17	2c9y	2c9y	NOUN
admet-854	55	18	,	,	PUNCT
admet-854	55	19	2ar7	2ar7	NUM
admet-854	55	20	,	,	PUNCT
admet-854	55	21	2bbw	2bbw	NUM
admet-854	55	22	,	,	PUNCT
admet-854	55	23	2bwj	2bwj	NUM
admet-854	55	24	,	,	PUNCT
admet-854	55	25	3hpq	3hpq	NUM
admet-854	55	26	,	,	PUNCT
admet-854	55	27	and	and	CCONJ
admet-854	55	28	1zip	1zip	NUM
admet-854	55	29	)	)	PUNCT
admet-854	55	30	are	be	AUX
admet-854	55	31	synthesized	synthesize	VERB
admet-854	55	32	in	in	ADP
admet-854	55	33	table	table	NOUN
admet-854	55	34	s1	s1	NOUN
admet-854	55	35	[	[	X
admet-854	55	36	32–34	32–34	NUM
admet-854	55	37	]	]	PUNCT
admet-854	55	38	.	.	PUNCT
admet-854	56	1	human	human	ADJ
admet-854	56	2	adenine	adenine	ADJ
admet-854	56	3	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	56	4	(	(	PUNCT
admet-854	56	5	aprt	aprt	PROPN
admet-854	56	6	)	)	PUNCT
admet-854	56	7	the	the	DET
admet-854	56	8	human	human	ADJ
admet-854	56	9	aptrs	aptrs	PROPN
admet-854	56	10	co	co	VERB
admet-854	56	11	-	-	VERB
admet-854	56	12	crystallized	crystallize	VERB
admet-854	56	13	with	with	ADP
admet-854	56	14	the	the	DET
admet-854	56	15	substrate	substrate	NOUN
admet-854	56	16	amp	amp	NOUN
admet-854	56	17	and	and	CCONJ
admet-854	56	18	with	with	ADP
admet-854	56	19	adenine	adenine	NOUN
admet-854	56	20	,	,	PUNCT
admet-854	56	21	allow	allow	VERB
admet-854	56	22	a	a	DET
admet-854	56	23	deep	deep	ADJ
admet-854	56	24	view	view	NOUN
admet-854	56	25	of	of	ADP
admet-854	56	26	the	the	DET
admet-854	56	27	amantadine	amantadine	NOUN
admet-854	56	28	interactions	interaction	NOUN
admet-854	56	29	with	with	ADP
admet-854	56	30	the	the	DET
admet-854	56	31	residues	residue	NOUN
admet-854	56	32	involved	involve	VERB
admet-854	56	33	in	in	ADP
admet-854	56	34	catalysis	catalysis	NOUN
admet-854	56	35	the	the	DET
admet-854	56	36	x	x	NOUN
admet-854	56	37	-	-	NOUN
admet-854	56	38	ray	ray	NOUN
admet-854	56	39	crystal	crystal	NOUN
admet-854	56	40	structures	structure	NOUN
admet-854	56	41	of	of	ADP
admet-854	56	42	the	the	DET
admet-854	56	43	aptrs	aptrs	PROPN
admet-854	56	44	included	include	VERB
admet-854	56	45	in	in	ADP
admet-854	56	46	the	the	DET
admet-854	56	47	study	study	NOUN
admet-854	56	48	(	(	PUNCT
admet-854	56	49	pdb	pdb	PROPN
admet-854	56	50	id(s	id(s	PUNCT
admet-854	56	51	)	)	PUNCT
admet-854	56	52	1ore	1ore	NUM
admet-854	56	53	,	,	PUNCT
admet-854	56	54	1zn7	1zn7	NUM
admet-854	56	55	,	,	PUNCT
admet-854	56	56	1zn8	1zn8	NUM
admet-854	56	57	,	,	PUNCT
admet-854	56	58	1zn9	1zn9	NUM
admet-854	56	59	,	,	PUNCT
admet-854	56	60	4x44	4x44	NOUN
admet-854	56	61	,	,	PUNCT
admet-854	56	62	and	and	CCONJ
admet-854	56	63	6fci	6fci	NOUN
admet-854	56	64	)	)	PUNCT
admet-854	56	65	are	be	AUX
admet-854	56	66	presented	present	VERB
admet-854	56	67	in	in	ADP
admet-854	56	68	the	the	DET
admet-854	56	69	table	table	NOUN
admet-854	56	70	s2	s2	NOUN
admet-854	57	1	[	[	X
admet-854	57	2	35–37	35–37	NOUN
admet-854	57	3	]	]	X
admet-854	57	4	.	.	PUNCT
admet-854	58	1	human	human	ADJ
admet-854	58	2	ecto-5’-nucleotidase	ecto-5’-nucleotidase	PROPN
admet-854	58	3	(	(	PUNCT
admet-854	58	4	nt5e	nt5e	PROPN
admet-854	58	5	)	)	PUNCT
admet-854	58	6	the	the	DET
admet-854	58	7	human	human	PROPN
admet-854	58	8	nt5es	nt5es	NUM
admet-854	58	9	co	co	NOUN
admet-854	58	10	-	-	VERB
admet-854	58	11	crystallized	crystallize	VERB
admet-854	58	12	with	with	ADP
admet-854	58	13	the	the	DET
admet-854	58	14	substrate	substrate	NOUN
admet-854	58	15	adenosine	adenosine	NOUN
admet-854	58	16	and	and	CCONJ
admet-854	58	17	with	with	ADP
admet-854	58	18	phosphomethylphosphonic	phosphomethylphosphonic	ADJ
admet-854	58	19	acid	acid	NOUN
admet-854	58	20	adenosyl	adenosyl	NOUN
admet-854	58	21	ester	ester	NOUN
admet-854	58	22	,	,	PUNCT
admet-854	58	23	allow	allow	VERB
admet-854	58	24	a	a	DET
admet-854	58	25	deep	deep	ADJ
admet-854	58	26	view	view	NOUN
admet-854	58	27	of	of	ADP
admet-854	58	28	the	the	DET
admet-854	58	29	amantadine	amantadine	NOUN
admet-854	58	30	interactions	interaction	NOUN
admet-854	58	31	with	with	ADP
admet-854	58	32	the	the	DET
admet-854	58	33	residues	residue	NOUN
admet-854	58	34	involved	involve	VERB
admet-854	58	35	in	in	ADP
admet-854	58	36	catalysis	catalysis	NOUN
admet-854	58	37	.	.	PUNCT
admet-854	59	1	the	the	DET
admet-854	59	2	x	x	NOUN
admet-854	59	3	-	-	NOUN
admet-854	59	4	ray	ray	NOUN
admet-854	59	5	crystal	crystal	NOUN
admet-854	59	6	structures	structure	NOUN
admet-854	59	7	of	of	ADP
admet-854	59	8	the	the	DET
admet-854	59	9	nt5es	nt5es	NUM
admet-854	59	10	included	include	VERB
admet-854	59	11	in	in	ADP
admet-854	59	12	the	the	DET
admet-854	59	13	study	study	NOUN
admet-854	59	14	(	(	PUNCT
admet-854	59	15	pdb	pdb	PROPN
admet-854	59	16	id(s	id(s	PUNCT
admet-854	59	17	)	)	PUNCT
admet-854	59	18	4h2i	4h2i	NOUN
admet-854	59	19	,	,	PUNCT
admet-854	59	20	4h2	4h2	NOUN
admet-854	59	21	g	g	NOUN
admet-854	59	22	,	,	PUNCT
admet-854	59	23	4h2f	4h2f	NOUN
admet-854	59	24	,	,	PUNCT
admet-854	59	25	and	and	CCONJ
admet-854	59	26	4h1s	4h1s	NUM
admet-854	59	27	)	)	PUNCT
admet-854	59	28	are	be	AUX
admet-854	59	29	presented	present	VERB
admet-854	59	30	in	in	ADP
admet-854	59	31	the	the	DET
admet-854	59	32	table	table	NOUN
admet-854	59	33	s3	s3	PROPN
admet-854	60	1	[	[	X
admet-854	60	2	38,39	38,39	NOUN
admet-854	60	3	]	]	X
admet-854	60	4	.	.	PUNCT
admet-854	61	1	human	human	ADJ
admet-854	61	2	ectonucleoside	ectonucleoside	NOUN
admet-854	61	3	triphosphate	triphosphate	NOUN
admet-854	61	4	diphosphohydrolase	diphosphohydrolase	NOUN
admet-854	61	5	1	1	NUM
admet-854	61	6	(	(	PUNCT
admet-854	61	7	entpd1	entpd1	NOUN
admet-854	61	8	)	)	PUNCT
admet-854	61	9	the	the	DET
admet-854	61	10	human	human	ADJ
admet-854	61	11	ndk3s	ndk3s	NOUN
admet-854	61	12	in	in	ADP
admet-854	61	13	closed	closed	ADJ
admet-854	61	14	-	-	PUNCT
admet-854	61	15	conformation	conformation	NOUN
admet-854	61	16	and	and	CCONJ
admet-854	61	17	without	without	ADP
admet-854	61	18	ligands	ligand	NOUN
admet-854	61	19	allows	allow	VERB
admet-854	61	20	a	a	DET
admet-854	61	21	thorough	thorough	ADJ
admet-854	61	22	analysis	analysis	NOUN
admet-854	61	23	of	of	ADP
admet-854	61	24	the	the	DET
admet-854	61	25	amantadine	amantadine	NOUN
admet-854	61	26	interactions	interaction	NOUN
admet-854	61	27	with	with	ADP
admet-854	61	28	the	the	DET
admet-854	61	29	catalytic	catalytic	ADJ
admet-854	61	30	site	site	NOUN
admet-854	61	31	.	.	PUNCT
admet-854	62	1	the	the	DET
admet-854	62	2	x	x	NOUN
admet-854	62	3	-	-	NOUN
admet-854	62	4	ray	ray	NOUN
admet-854	62	5	crystal	crystal	NOUN
admet-854	62	6	structures	structure	NOUN
admet-854	62	7	of	of	ADP
admet-854	62	8	the	the	DET
admet-854	62	9	ndk3s	ndk3s	NOUN
admet-854	62	10	included	include	VERB
admet-854	62	11	in	in	ADP
admet-854	62	12	the	the	DET
admet-854	62	13	study	study	NOUN
admet-854	62	14	(	(	PUNCT
admet-854	62	15	pdb	pdb	PROPN
admet-854	62	16	id(s	id(s	PUNCT
admet-854	62	17	)	)	PUNCT
admet-854	62	18	1zs6	1zs6	NUM
admet-854	62	19	,	,	PUNCT
admet-854	62	20	2hvd	2hvd	NUM
admet-854	62	21	,	,	PUNCT
admet-854	62	22	2hve	2hve	NUM
admet-854	62	23	,	,	PUNCT
admet-854	62	24	1jxv	1jxv	NUM
admet-854	62	25	,	,	PUNCT
admet-854	62	26	and	and	CCONJ
admet-854	62	27	3bbb	3bbb	NUM
admet-854	62	28	)	)	PUNCT
admet-854	62	29	are	be	AUX
admet-854	62	30	presented	present	VERB
admet-854	62	31	in	in	ADP
admet-854	62	32	the	the	DET
admet-854	62	33	table	table	NOUN
admet-854	62	34	s4	s4	PROPN
admet-854	63	1	[	[	X
admet-854	63	2	40–42	40–42	PROPN
admet-854	63	3	]	]	PUNCT
admet-854	63	4	.	.	PUNCT
admet-854	64	1	human	human	ADJ
admet-854	64	2	purine	purine	NOUN
admet-854	64	3	nucleoside	nucleoside	NOUN
admet-854	64	4	phosphorylase	phosphorylase	NOUN
admet-854	64	5	1	1	NUM
admet-854	64	6	(	(	PUNCT
admet-854	64	7	pnp1	pnp1	PROPN
admet-854	64	8	)	)	PUNCT
admet-854	64	9	the	the	DET
admet-854	64	10	many	many	ADJ
admet-854	64	11	x	x	NOUN
admet-854	64	12	-	-	NOUN
admet-854	64	13	ray	ray	ADJ
admet-854	64	14	3d	3d	PROPN
admet-854	64	15	structures	structure	NOUN
admet-854	64	16	of	of	ADP
admet-854	64	17	human	human	ADJ
admet-854	64	18	pnp1	pnp1	NOUN
admet-854	64	19	co	co	VERB
admet-854	64	20	-	-	VERB
admet-854	64	21	crystallized	crystallize	VERB
admet-854	64	22	with	with	ADP
admet-854	64	23	the	the	DET
admet-854	64	24	substrate	substrate	NOUN
admet-854	64	25	or	or	CCONJ
admet-854	64	26	analag	analag	NOUN
admet-854	64	27	substrate	substrate	NOUN
admet-854	64	28	allows	allow	VERB
admet-854	64	29	a	a	DET
admet-854	64	30	good	good	ADJ
admet-854	64	31	interpretation	interpretation	NOUN
admet-854	64	32	of	of	ADP
admet-854	64	33	the	the	DET
admet-854	64	34	molecular	molecular	ADJ
admet-854	64	35	docking	docking	NOUN
admet-854	64	36	results	result	NOUN
admet-854	64	37	of	of	ADP
admet-854	64	38	amantadine	amantadine	NOUN
admet-854	64	39	with	with	ADP
admet-854	64	40	pnp1	pnp1	NOUN
admet-854	64	41	.	.	PUNCT
admet-854	65	1	the	the	DET
admet-854	65	2	x	x	NOUN
admet-854	65	3	-	-	NOUN
admet-854	65	4	ray	ray	NOUN
admet-854	65	5	crystal	crystal	NOUN
admet-854	65	6	structures	structure	NOUN
admet-854	65	7	of	of	ADP
admet-854	65	8	the	the	DET
admet-854	65	9	pnp1s	pnp1s	PROPN
admet-854	65	10	included	include	VERB
admet-854	65	11	in	in	ADP
admet-854	65	12	the	the	DET
admet-854	65	13	study	study	NOUN
admet-854	65	14	(	(	PUNCT
admet-854	65	15	pdb	pdb	PROPN
admet-854	65	16	id(s	id(s	PUNCT
admet-854	65	17	)	)	PUNCT
admet-854	65	18	1ula	1ula	NUM
admet-854	65	19	,	,	PUNCT
admet-854	65	20	1ulb	1ulb	NOUN
admet-854	65	21	,	,	PUNCT
admet-854	65	22	2a0w	2a0w	ADJ
admet-854	65	23	,	,	PUNCT
admet-854	65	24	2a0x	2a0x	NUM
admet-854	65	25	,	,	PUNCT
admet-854	65	26	2a0y	2a0y	NUM
admet-854	65	27	,	,	PUNCT
admet-854	65	28	1rsz	1rsz	NUM
admet-854	65	29	,	,	PUNCT
admet-854	65	30	and	and	CCONJ
admet-854	65	31	1rfg	1rfg	NUM
admet-854	65	32	)	)	PUNCT
admet-854	65	33	are	be	AUX
admet-854	65	34	presented	present	VERB
admet-854	65	35	in	in	ADP
admet-854	65	36	the	the	DET
admet-854	65	37	table	table	NOUN
admet-854	65	38	s5	s5	PROPN
admet-854	65	39	[	[	X
admet-854	65	40	43–45	43–45	NUM
admet-854	65	41	]	]	PUNCT
admet-854	65	42	.	.	PUNCT
admet-854	66	1	creatinin	creatinin	PROPN
admet-854	66	2	kinases	kinase	NOUN
admet-854	66	3	(	(	PUNCT
admet-854	66	4	ck	ck	PROPN
admet-854	66	5	)	)	PUNCT
admet-854	66	6	due	due	ADP
admet-854	66	7	to	to	ADP
admet-854	66	8	the	the	DET
admet-854	66	9	different	different	ADJ
admet-854	66	10	isoforms	isoform	NOUN
admet-854	66	11	of	of	ADP
admet-854	66	12	the	the	DET
admet-854	66	13	cks	ck	NOUN
admet-854	66	14	,	,	PUNCT
admet-854	66	15	all	all	DET
admet-854	66	16	these	these	DET
admet-854	66	17	isoforms	isoform	NOUN
admet-854	66	18	were	be	AUX
admet-854	66	19	selected	select	VERB
admet-854	66	20	.	.	PUNCT
admet-854	67	1	x	x	X
admet-854	67	2	-	-	PUNCT
admet-854	67	3	ray	ray	NOUN
admet-854	67	4	3d	3d	PROPN
admet-854	67	5	structures	structure	NOUN
admet-854	67	6	of	of	ADP
admet-854	67	7	human	human	ADJ
admet-854	67	8	cks	ck	NOUN
admet-854	67	9	are	be	AUX
admet-854	67	10	compared	compare	VERB
admet-854	67	11	to	to	ADP
admet-854	67	12	cks	ck	NOUN
admet-854	67	13	of	of	ADP
admet-854	67	14	other	other	ADJ
admet-854	67	15	organisms	organism	NOUN
admet-854	67	16	,	,	PUNCT
admet-854	67	17	due	due	ADP
admet-854	67	18	to	to	ADP
admet-854	67	19	the	the	DET
admet-854	67	20	small	small	ADJ
admet-854	67	21	number	number	NOUN
admet-854	67	22	of	of	ADP
admet-854	67	23	human	human	ADJ
admet-854	67	24	cks	ck	NOUN
admet-854	67	25	structures	structure	NOUN
admet-854	67	26	deposed	depose	VERB
admet-854	67	27	in	in	ADP
admet-854	67	28	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	67	29	https://www.rcsb.org/	https://www.rcsb.org/	VERB
admet-854	67	30	mihaela	mihaela	PROPN
admet-854	67	31	ileana	ileana	PROPN
admet-854	67	32	ionescu	ionescu	PROPN
admet-854	67	33	admet	admet	PROPN
admet-854	67	34	&	&	CCONJ
admet-854	67	35	dmpk	dmpk	PROPN
admet-854	67	36	8(2	8(2	NUM
admet-854	67	37	)	)	PUNCT
admet-854	67	38	(	(	PUNCT
admet-854	67	39	2020	2020	NUM
admet-854	67	40	)	)	PUNCT
admet-854	67	41	149	149	NUM
admet-854	67	42	-	-	SYM
admet-854	67	43	175	175	NUM
admet-854	67	44	152	152	NUM
admet-854	67	45	pdb	pdb	NOUN
admet-854	67	46	.	.	PUNCT
admet-854	68	1	the	the	DET
admet-854	68	2	x	x	NOUN
admet-854	68	3	-	-	NOUN
admet-854	68	4	ray	ray	NOUN
admet-854	68	5	crystal	crystal	NOUN
admet-854	68	6	structures	structure	NOUN
admet-854	68	7	of	of	ADP
admet-854	68	8	the	the	DET
admet-854	68	9	cks	ck	NOUN
admet-854	68	10	included	include	VERB
admet-854	68	11	in	in	ADP
admet-854	68	12	the	the	DET
admet-854	68	13	study	study	NOUN
admet-854	68	14	(	(	PUNCT
admet-854	68	15	pdb	pdb	PROPN
admet-854	68	16	id(s	id(s	PUNCT
admet-854	68	17	)	)	PUNCT
admet-854	68	18	1crk	1crk	NUM
admet-854	68	19	,	,	PUNCT
admet-854	68	20	4z9	4z9	NUM
admet-854	68	21	m	m	NOUN
admet-854	68	22	,	,	PUNCT
admet-854	68	23	2crk	2crk	NUM
admet-854	68	24	,	,	PUNCT
admet-854	68	25	1i0e	1i0e	NUM
admet-854	68	26	,	,	PUNCT
admet-854	68	27	1u6r	1u6r	NUM
admet-854	68	28	,	,	PUNCT
admet-854	68	29	3drb	3drb	NUM
admet-854	68	30	,	,	PUNCT
admet-854	68	31	3dre	3dre	PROPN
admet-854	68	32	,	,	PUNCT
admet-854	68	33	1qh4	1qh4	NUM
admet-854	68	34	,	,	PUNCT
admet-854	68	35	and	and	CCONJ
admet-854	68	36	1g0w	1g0w	NUM
admet-854	68	37	)	)	PUNCT
admet-854	68	38	are	be	AUX
admet-854	68	39	presented	present	VERB
admet-854	68	40	in	in	ADP
admet-854	68	41	the	the	DET
admet-854	68	42	table	table	NOUN
admet-854	68	43	s6	s6	PROPN
admet-854	68	44	[	[	X
admet-854	68	45	46–52	46–52	NUM
admet-854	68	46	]	]	PUNCT
admet-854	68	47	.	.	PUNCT
admet-854	69	1	inclusion	inclusion	NOUN
admet-854	69	2	and	and	CCONJ
admet-854	69	3	exclusion	exclusion	NOUN
admet-854	69	4	criteria	criterion	NOUN
admet-854	69	5	inclusion	inclusion	NOUN
admet-854	69	6	criteria	criterion	NOUN
admet-854	69	7	:	:	PUNCT
admet-854	69	8	the	the	DET
admet-854	69	9	human	human	ADJ
admet-854	69	10	aks	ak	NOUN
admet-854	69	11	and	and	CCONJ
admet-854	69	12	aks	ak	NOUN
admet-854	69	13	form	form	NOUN
admet-854	69	14	other	other	ADJ
admet-854	69	15	eucaryotes	eucaryote	NOUN
admet-854	69	16	with	with	ADP
admet-854	69	17	x	x	NOUN
admet-854	69	18	-	-	NOUN
admet-854	69	19	ray	ray	ADJ
admet-854	69	20	3d	3d	NUM
admet-854	69	21	structure	structure	NOUN
admet-854	69	22	in	in	ADP
admet-854	69	23	closedconformation	closedconformation	NOUN
admet-854	69	24	–	–	PUNCT
admet-854	69	25	co	co	VERB
admet-854	69	26	-	-	VERB
admet-854	69	27	crystallized	crystallize	VERB
admet-854	69	28	with	with	ADP
admet-854	69	29	substrate	substrate	NOUN
admet-854	69	30	or	or	CCONJ
admet-854	69	31	analog	analog	NOUN
admet-854	69	32	substrate	substrate	NOUN
admet-854	69	33	.	.	PUNCT
admet-854	70	1	for	for	ADP
admet-854	70	2	further	further	ADJ
admet-854	70	3	comparison	comparison	NOUN
admet-854	70	4	,	,	PUNCT
admet-854	70	5	ak1	ak1	ADV
admet-854	70	6	from	from	ADP
admet-854	70	7	zebrafish	zebrafish	PROPN
admet-854	70	8	(	(	PUNCT
admet-854	70	9	danio	danio	NOUN
admet-854	70	10	rerio	rerio	PROPN
admet-854	70	11	)	)	PUNCT
admet-854	70	12	and	and	CCONJ
admet-854	70	13	two	two	NUM
admet-854	70	14	bacterial	bacterial	ADJ
admet-854	70	15	aks	ak	NOUN
admet-854	70	16	in	in	ADP
admet-854	70	17	closed	closed	ADJ
admet-854	70	18	-	-	PUNCT
admet-854	70	19	conformation	conformation	NOUN
admet-854	70	20	were	be	AUX
admet-854	70	21	included	include	VERB
admet-854	70	22	–	–	PUNCT
admet-854	70	23	one	one	NUM
admet-854	70	24	from	from	ADP
admet-854	70	25	a	a	DET
admet-854	70	26	gramnegative	gramnegative	ADJ
admet-854	70	27	bacteria	bacteria	NOUN
admet-854	70	28	,	,	PUNCT
admet-854	70	29	e.coli	e.coli	NOUN
admet-854	70	30	,	,	PUNCT
admet-854	70	31	and	and	CCONJ
admet-854	70	32	one	one	NUM
admet-854	70	33	from	from	ADP
admet-854	70	34	a	a	DET
admet-854	70	35	gram	gram	NOUN
admet-854	70	36	-	-	PUNCT
admet-854	70	37	positive	positive	ADJ
admet-854	70	38	bacteria	bacteria	NOUN
admet-854	70	39	,	,	PUNCT
admet-854	70	40	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	70	41	.	.	PUNCT
admet-854	71	1	other	other	ADJ
admet-854	71	2	human	human	ADJ
admet-854	71	3	enzymes	enzyme	NOUN
admet-854	71	4	described	describe	VERB
admet-854	71	5	to	to	PART
admet-854	71	6	be	be	AUX
admet-854	71	7	dysregulated	dysregulate	VERB
admet-854	71	8	in	in	ADP
admet-854	71	9	pd	pd	PROPN
admet-854	71	10	(	(	PUNCT
admet-854	71	11	aprt	aprt	PROPN
admet-854	71	12	,	,	PUNCT
admet-854	71	13	nt5e	nt5e	PROPN
admet-854	71	14	,	,	PUNCT
admet-854	71	15	entpd1	entpd1	NOUN
admet-854	71	16	,	,	PUNCT
admet-854	71	17	ndk3	ndk3	PROPN
admet-854	71	18	,	,	PUNCT
admet-854	71	19	and	and	CCONJ
admet-854	71	20	pnp1	pnp1	PROPN
admet-854	71	21	)	)	PUNCT
admet-854	71	22	.	.	PUNCT
admet-854	72	1	the	the	DET
admet-854	72	2	human	human	ADJ
admet-854	72	3	cks	ck	NOUN
admet-854	72	4	were	be	AUX
admet-854	72	5	also	also	ADV
admet-854	72	6	tested	test	VERB
admet-854	72	7	because	because	SCONJ
admet-854	72	8	their	their	PRON
admet-854	72	9	major	major	ADJ
admet-854	72	10	role	role	NOUN
admet-854	72	11	in	in	ADP
admet-854	72	12	nucleotide	nucleotide	ADJ
admet-854	72	13	ratios	ratio	NOUN
admet-854	72	14	in	in	ADP
admet-854	72	15	muscles	muscle	NOUN
admet-854	72	16	.	.	PUNCT
admet-854	73	1	when	when	SCONJ
admet-854	73	2	enzyme	enzyme	NOUN
admet-854	73	3	of	of	ADP
admet-854	73	4	human	human	ADJ
admet-854	73	5	origin	origin	NOUN
admet-854	73	6	was	be	AUX
admet-854	73	7	not	not	PART
admet-854	73	8	found	find	VERB
admet-854	73	9	in	in	ADP
admet-854	73	10	pdb	pdb	PROPN
admet-854	73	11	,	,	PUNCT
admet-854	73	12	the	the	DET
admet-854	73	13	same	same	ADJ
admet-854	73	14	enzyme	enzyme	NOUN
admet-854	73	15	of	of	ADP
admet-854	73	16	other	other	ADJ
admet-854	73	17	origin	origin	NOUN
admet-854	73	18	was	be	AUX
admet-854	73	19	retrieved	retrieve	VERB
admet-854	73	20	.	.	PUNCT
admet-854	74	1	exclusion	exclusion	NOUN
admet-854	74	2	criteria	criterion	NOUN
admet-854	74	3	:	:	PUNCT
admet-854	74	4	human	human	ADJ
admet-854	74	5	aks	ak	NOUN
admet-854	74	6	in	in	ADP
admet-854	74	7	open	open	ADJ
admet-854	74	8	conformation	conformation	NOUN
admet-854	74	9	or	or	CCONJ
admet-854	74	10	with	with	ADP
admet-854	74	11	no	no	DET
admet-854	74	12	x	x	NOUN
admet-854	74	13	-	-	NOUN
admet-854	74	14	ray	ray	ADJ
admet-854	74	15	3d	3d	NOUN
admet-854	74	16	structure	structure	NOUN
admet-854	74	17	records	record	NOUN
admet-854	74	18	in	in	ADP
admet-854	74	19	public	public	ADJ
admet-854	74	20	databases	database	NOUN
admet-854	74	21	.	.	PUNCT
admet-854	75	1	aks	ak	NOUN
admet-854	75	2	from	from	ADP
admet-854	75	3	other	other	ADJ
admet-854	75	4	organisms	organism	NOUN
admet-854	75	5	with	with	ADP
admet-854	75	6	the	the	DET
admet-854	75	7	exception	exception	NOUN
admet-854	75	8	of	of	ADP
admet-854	75	9	the	the	DET
admet-854	75	10	aks	ak	NOUN
admet-854	75	11	selected	select	VERB
admet-854	75	12	in	in	ADP
admet-854	75	13	the	the	DET
admet-854	75	14	inclusion	inclusion	NOUN
admet-854	75	15	criteria	criterion	NOUN
admet-854	75	16	for	for	ADP
admet-854	75	17	further	further	ADJ
admet-854	75	18	comparisons	comparison	NOUN
admet-854	75	19	.	.	PUNCT
admet-854	76	1	molecular	molecular	ADJ
admet-854	76	2	docking	docking	NOUN
admet-854	76	3	procedure	procedure	NOUN
admet-854	76	4	adenylate	adenylate	ADJ
admet-854	76	5	kinases	kinase	NOUN
admet-854	76	6	preparation	preparation	NOUN
admet-854	76	7	as	as	ADP
admet-854	76	8	receptors	receptor	NOUN
admet-854	76	9	for	for	ADP
admet-854	76	10	the	the	DET
admet-854	76	11	present	present	ADJ
admet-854	76	12	study	study	NOUN
admet-854	76	13	were	be	AUX
admet-854	76	14	selected	select	VERB
admet-854	76	15	from	from	ADP
admet-854	76	16	pdb	pdb	PROPN
admet-854	76	17	database	database	NOUN
admet-854	76	18	(	(	PUNCT
admet-854	76	19	https://www.rcsb.org/	https://www.rcsb.org/	ADV
admet-854	76	20	)	)	PUNCT
admet-854	76	21	the	the	DET
admet-854	76	22	aks	aks	PROPN
admet-854	76	23	3d	3d	NUM
admet-854	76	24	structures	structure	NOUN
admet-854	76	25	in	in	ADP
admet-854	76	26	closed	closed	ADJ
admet-854	76	27	conformation	conformation	NOUN
admet-854	76	28	–	–	PUNCT
admet-854	76	29	co	co	VERB
admet-854	76	30	-	-	VERB
admet-854	76	31	crystallized	crystallize	VERB
admet-854	76	32	with	with	ADP
admet-854	76	33	substrate	substrate	NOUN
admet-854	76	34	or	or	CCONJ
admet-854	76	35	analog	analog	NOUN
admet-854	76	36	substrate	substrate	NOUN
admet-854	76	37	.	.	PUNCT
admet-854	77	1	the	the	DET
admet-854	77	2	aks	ak	NOUN
admet-854	77	3	x	x	NOUN
admet-854	77	4	-	-	NOUN
admet-854	77	5	ray	ray	ADJ
admet-854	77	6	3d	3d	NOUN
admet-854	77	7	structures	structure	NOUN
admet-854	77	8	downloaded	download	VERB
admet-854	77	9	from	from	ADP
admet-854	77	10	the	the	DET
admet-854	77	11	pdb	pdb	PROPN
admet-854	77	12	database	database	NOUN
admet-854	77	13	as	as	SCONJ
admet-854	77	14	pdb	pdb	PROPN
admet-854	77	15	files	file	NOUN
admet-854	77	16	were	be	AUX
admet-854	77	17	prepared	prepare	VERB
admet-854	77	18	as	as	ADP
admet-854	77	19	receptors	receptor	NOUN
admet-854	77	20	.	.	PUNCT
admet-854	78	1	all	all	DET
admet-854	78	2	solvent	solvent	ADJ
admet-854	78	3	molecules	molecule	NOUN
admet-854	78	4	,	,	PUNCT
admet-854	78	5	the	the	DET
admet-854	78	6	ions	ion	NOUN
admet-854	78	7	and	and	CCONJ
admet-854	78	8	the	the	DET
admet-854	78	9	substrates	substrate	NOUN
admet-854	78	10	were	be	AUX
admet-854	78	11	removed	remove	VERB
admet-854	78	12	.	.	PUNCT
admet-854	79	1	in	in	ADP
admet-854	79	2	the	the	DET
admet-854	79	3	case	case	NOUN
admet-854	79	4	of	of	ADP
admet-854	79	5	multimeric	multimeric	ADJ
admet-854	79	6	aks	ak	NOUN
admet-854	79	7	,	,	PUNCT
admet-854	79	8	only	only	ADV
admet-854	79	9	the	the	DET
admet-854	79	10	chain	chain	NOUN
admet-854	79	11	that	that	PRON
admet-854	79	12	was	be	AUX
admet-854	79	13	crystallized	crystallize	VERB
admet-854	79	14	with	with	ADP
admet-854	79	15	substrate	substrate	NOUN
admet-854	79	16	or	or	CCONJ
admet-854	79	17	substrate	substrate	NOUN
admet-854	79	18	analog	analog	NOUN
admet-854	79	19	was	be	AUX
admet-854	79	20	selected	select	VERB
admet-854	79	21	.	.	PUNCT
admet-854	80	1	three	three	NUM
admet-854	80	2	chains	chain	NOUN
admet-854	80	3	were	be	AUX
admet-854	80	4	selected	select	VERB
admet-854	80	5	for	for	ADP
admet-854	80	6	human	human	ADJ
admet-854	80	7	ak5	ak5	NOUN
admet-854	80	8	2bwj	2bwj	NOUN
admet-854	80	9	–	–	PUNCT
admet-854	80	10	chains	chain	NOUN
admet-854	80	11	b	b	NOUN
admet-854	80	12	,	,	PUNCT
admet-854	80	13	c	c	NOUN
admet-854	80	14	,	,	PUNCT
admet-854	80	15	and	and	CCONJ
admet-854	80	16	f	f	X
admet-854	80	17	–	–	PUNCT
admet-854	80	18	all	all	DET
admet-854	80	19	three	three	NUM
admet-854	80	20	crystallized	crystallize	VERB
admet-854	80	21	with	with	ADP
admet-854	80	22	amp	amp	NOUN
admet-854	80	23	but	but	CCONJ
admet-854	80	24	with	with	ADP
admet-854	80	25	different	different	ADJ
admet-854	80	26	interactions	interaction	NOUN
admet-854	80	27	with	with	ADP
admet-854	80	28	amp	amp	PROPN
admet-854	80	29	.	.	PUNCT
admet-854	81	1	thus	thus	ADV
admet-854	81	2	,	,	PUNCT
admet-854	81	3	in	in	ADP
admet-854	81	4	3d	3d	PROPN
admet-854	81	5	crystal	crystal	NOUN
admet-854	81	6	structure	structure	NOUN
admet-854	81	7	from	from	ADP
admet-854	81	8	pdb	pdb	PROPN
admet-854	81	9	,	,	PUNCT
admet-854	81	10	two	two	NUM
admet-854	81	11	residues	residue	NOUN
admet-854	81	12	in	in	ADP
admet-854	81	13	the	the	DET
admet-854	81	14	chain	chain	NOUN
admet-854	81	15	b	b	NOUN
admet-854	81	16	form	form	NOUN
admet-854	81	17	hydrophobic	hydrophobic	NOUN
admet-854	81	18	interaction	interaction	NOUN
admet-854	81	19	with	with	ADP
admet-854	81	20	amp	amp	PROPN
admet-854	81	21	(	(	PUNCT
admet-854	81	22	gln29	gln29	NOUN
admet-854	81	23	and	and	CCONJ
admet-854	81	24	his39	his39	PROPN
admet-854	81	25	)	)	PUNCT
admet-854	81	26	and	and	CCONJ
admet-854	81	27	the	the	DET
admet-854	81	28	gln29	gln29	NOUN
admet-854	81	29	in	in	ADP
admet-854	81	30	the	the	DET
admet-854	81	31	chain	chain	NOUN
admet-854	81	32	f	f	PROPN
admet-854	81	33	forms	form	VERB
admet-854	81	34	a	a	DET
admet-854	81	35	hydrophobic	hydrophobic	NOUN
admet-854	81	36	interaction	interaction	NOUN
admet-854	81	37	with	with	ADP
admet-854	81	38	amp	amp	NOUN
admet-854	81	39	and	and	CCONJ
admet-854	81	40	no	no	DET
admet-854	81	41	interaction	interaction	NOUN
admet-854	81	42	with	with	ADP
admet-854	81	43	amp	amp	NOUN
admet-854	81	44	for	for	ADP
admet-854	81	45	chain	chain	NOUN
admet-854	81	46	c.	c.	PROPN
admet-854	81	47	ligand	ligand	PROPN
admet-854	81	48	preparation	preparation	NOUN
admet-854	81	49	the	the	DET
admet-854	81	50	3d	3d	NUM
admet-854	81	51	structure	structure	NOUN
admet-854	81	52	of	of	ADP
admet-854	81	53	ligands	ligand	NOUN
admet-854	81	54	was	be	AUX
admet-854	81	55	retrieved	retrieve	VERB
admet-854	81	56	from	from	ADP
admet-854	81	57	the	the	DET
admet-854	81	58	pubchem	pubchem	NOUN
admet-854	81	59	compound	compound	NOUN
admet-854	81	60	database	database	NOUN
admet-854	81	61	(	(	PUNCT
admet-854	81	62	https://www.ncbi.nlm.nih.gov/pccompound/	https://www.ncbi.nlm.nih.gov/pccompound/	NOUN
admet-854	81	63	)	)	PUNCT
admet-854	81	64	.	.	PUNCT
admet-854	82	1	molecular	molecular	ADJ
admet-854	82	2	docking	docking	NOUN
admet-854	82	3	experiments	experiment	NOUN
admet-854	82	4	were	be	AUX
admet-854	82	5	performed	perform	VERB
admet-854	82	6	with	with	ADP
admet-854	82	7	the	the	DET
admet-854	82	8	unionized	unionize	VERB
admet-854	82	9	amantadine	amantadine	NOUN
admet-854	82	10	(	(	PUNCT
admet-854	82	11	pubchem	pubchem	NOUN
admet-854	82	12	cid	cid	NOUN
admet-854	82	13	2130	2130	NUM
admet-854	82	14	)	)	PUNCT
admet-854	82	15	and	and	CCONJ
admet-854	82	16	ionized	ionize	VERB
admet-854	82	17	amantadine	amantadine	NOUN
admet-854	82	18	(	(	PUNCT
admet-854	82	19	with	with	ADP
admet-854	82	20	–	–	PUNCT
admet-854	82	21	nh3	nh3	NOUN
admet-854	82	22	+	+	NOUN
admet-854	82	23	)	)	PUNCT
admet-854	82	24	as	as	SCONJ
admet-854	82	25	ligand	ligand	ADJ
admet-854	82	26	.	.	PUNCT
admet-854	83	1	the	the	DET
admet-854	83	2	ionized	ionized	ADJ
admet-854	83	3	amantadine	amantadine	NOUN
admet-854	83	4	was	be	AUX
admet-854	83	5	prepared	prepare	VERB
admet-854	83	6	in	in	ADP
admet-854	83	7	biovia	biovia	NOUN
admet-854	83	8	program	program	NOUN
admet-854	83	9	by	by	ADP
admet-854	83	10	adding	add	VERB
admet-854	83	11	one	one	NUM
admet-854	83	12	hydrogen	hydrogen	NOUN
admet-854	83	13	ion	ion	NOUN
admet-854	83	14	to	to	ADP
admet-854	83	15	the	the	DET
admet-854	83	16	unionized	unionized	ADJ
admet-854	83	17	amandatine	amandatine	NOUN
admet-854	83	18	structure	structure	NOUN
admet-854	83	19	.	.	PUNCT
admet-854	84	1	the	the	DET
admet-854	84	2	redocking	redocking	NOUN
admet-854	84	3	experiments	experiment	NOUN
admet-854	84	4	were	be	AUX
admet-854	84	5	performed	perform	VERB
admet-854	84	6	with	with	ADP
admet-854	84	7	the	the	DET
admet-854	84	8	substrate	substrate	NOUN
admet-854	84	9	/	/	SYM
admet-854	84	10	substrate	substrate	NOUN
admet-854	84	11	analog	analog	NOUN
admet-854	84	12	with	with	ADP
admet-854	84	13	which	which	PRON
admet-854	84	14	the	the	DET
admet-854	84	15	aks	ak	NOUN
admet-854	84	16	were	be	AUX
admet-854	84	17	co	co	VERB
admet-854	84	18	-	-	VERB
admet-854	84	19	crystallized	crystallized	ADJ
admet-854	84	20	in	in	ADP
admet-854	84	21	the	the	DET
admet-854	84	22	pdb	pdb	NOUN
admet-854	84	23	;	;	PUNCT
admet-854	84	24	the	the	DET
admet-854	84	25	3d	3d	NUM
admet-854	84	26	structure	structure	NOUN
admet-854	84	27	of	of	ADP
admet-854	84	28	the	the	DET
admet-854	84	29	ligands	ligand	NOUN
admet-854	84	30	was	be	AUX
admet-854	84	31	downloaded	download	VERB
admet-854	84	32	from	from	ADP
admet-854	84	33	the	the	DET
admet-854	84	34	pdb	pdb	PROPN
admet-854	84	35	database	database	NOUN
admet-854	84	36	as	as	ADP
admet-854	84	37	sdf	sdf	NOUN
admet-854	84	38	file	file	NOUN
admet-854	84	39	and	and	CCONJ
admet-854	84	40	visualize	visualize	VERB
admet-854	84	41	it	it	PRON
admet-854	84	42	on	on	ADP
admet-854	84	43	dassault	dassault	NOUN
admet-854	84	44	systèmes	systèmes	PROPN
admet-854	84	45	biova	biova	PROPN
admet-854	84	46	program	program	PROPN
admet-854	84	47	–	–	PUNCT
admet-854	84	48	discovery	discovery	NOUN
admet-854	84	49	studio	studio	NOUN
admet-854	84	50	modeling	modeling	NOUN
admet-854	84	51	environment	environment	NOUN
admet-854	84	52	,	,	PUNCT
admet-854	84	53	release	release	NOUN
admet-854	84	54	2017	2017	NUM
admet-854	84	55	,	,	PUNCT
admet-854	84	56	san	san	PROPN
admet-854	84	57	diego	diego	PROPN
admet-854	84	58	:	:	PUNCT
admet-854	84	59	dassault	dassault	NOUN
admet-854	84	60	systèmes	système	NOUN
admet-854	84	61	,	,	PUNCT
admet-854	84	62	2016	2016	NUM
admet-854	84	63	(	(	PUNCT
admet-854	84	64	http://accelrys.com	http://accelrys.com	X
admet-854	84	65	)	)	PUNCT
admet-854	84	66	.	.	PUNCT
admet-854	85	1	further	further	ADJ
admet-854	85	2	preparations	preparation	NOUN
admet-854	85	3	for	for	ADP
admet-854	85	4	molecular	molecular	ADJ
admet-854	85	5	docking	docking	NOUN
admet-854	85	6	were	be	AUX
admet-854	85	7	done	do	VERB
admet-854	85	8	by	by	ADP
admet-854	85	9	autodocktools	autodocktool	NOUN
admet-854	85	10	.	.	PUNCT
admet-854	86	1	molecular	molecular	ADJ
admet-854	86	2	docking	docking	NOUN
admet-854	86	3	protocol	protocol	NOUN
admet-854	86	4	protein	protein	NOUN
admet-854	86	5	-	-	PUNCT
admet-854	86	6	ligand	ligand	NOUN
admet-854	86	7	docking	docking	NOUN
admet-854	86	8	experiments	experiment	NOUN
admet-854	86	9	were	be	AUX
admet-854	86	10	performed	perform	VERB
admet-854	86	11	with	with	ADP
admet-854	86	12	the	the	DET
admet-854	86	13	autodock4.2	autodock4.2	NOUN
admet-854	86	14	program	program	NOUN
admet-854	86	15	,	,	PUNCT
admet-854	86	16	distributed	distribute	VERB
admet-854	86	17	as	as	ADP
admet-854	86	18	open	open	ADJ
admet-854	86	19	source	source	NOUN
admet-854	86	20	under	under	ADP
admet-854	86	21	a	a	DET
admet-854	86	22	gpl	gpl	NOUN
admet-854	86	23	license	license	NOUN
admet-854	86	24	(	(	PUNCT
admet-854	86	25	http://autodock.scripps.edu)[53–55	http://autodock.scripps.edu)[53–55	NOUN
admet-854	86	26	]	]	PUNCT
admet-854	86	27	.	.	PUNCT
admet-854	87	1	the	the	DET
admet-854	87	2	molecular	molecular	ADJ
admet-854	87	3	docking	docking	NOUN
admet-854	87	4	data	datum	NOUN
admet-854	87	5	analysis	analysis	NOUN
admet-854	87	6	was	be	AUX
admet-854	87	7	made	make	VERB
admet-854	87	8	on	on	ADP
admet-854	87	9	windows	window	NOUN
admet-854	87	10	platform	platform	NOUN
admet-854	87	11	using	use	VERB
admet-854	87	12	the	the	DET
admet-854	87	13	dassault	dassault	NOUN
admet-854	87	14	systèmes	système	NOUN
admet-854	87	15	biova	biova	PROPN
admet-854	87	16	program	program	PROPN
admet-854	87	17	.	.	PUNCT
admet-854	88	1	also	also	ADV
admet-854	88	2	,	,	PUNCT
admet-854	88	3	cygwin	cygwin	PROPN
admet-854	88	4	dll	dll	PROPN
admet-854	88	5	(	(	PUNCT
admet-854	88	6	cygwin1.dll	cygwin1.dll	NOUN
admet-854	88	7	)	)	PUNCT
admet-854	88	8	terminal	terminal	NOUN
admet-854	88	9	was	be	AUX
admet-854	88	10	used	use	VERB
admet-854	88	11	for	for	ADP
admet-854	88	12	the	the	DET
admet-854	88	13	running	running	NOUN
admet-854	88	14	of	of	ADP
admet-854	88	15	molecular	molecular	ADJ
admet-854	88	16	docking	docking	NOUN
admet-854	88	17	scripts	script	NOUN
admet-854	88	18	on	on	ADP
admet-854	88	19	windows	window	NOUN
admet-854	88	20	platform	platform	NOUN
admet-854	88	21	.	.	PUNCT
admet-854	89	1	the	the	DET
admet-854	89	2	molecular	molecular	ADJ
admet-854	89	3	docking	docking	NOUN
admet-854	89	4	algorithm	algorithm	NOUN
admet-854	89	5	employed	employ	VERB
admet-854	89	6	was	be	AUX
admet-854	89	7	with	with	ADP
admet-854	89	8	a	a	DET
admet-854	89	9	rigid	rigid	ADJ
admet-854	89	10	aks	ak	NOUN
admet-854	89	11	structure	structure	NOUN
admet-854	89	12	and	and	CCONJ
admet-854	89	13	a	a	DET
admet-854	89	14	ligand	ligand	ADJ
admet-854	89	15	flexibility	flexibility	NOUN
admet-854	89	16	with	with	ADP
admet-854	89	17	1	1	NUM
admet-854	89	18	-	-	SYM
admet-854	89	19	6	6	NUM
admet-854	89	20	https://www.rcsb.org/	https://www.rcsb.org/	NOUN
admet-854	89	21	https://www.ncbi.nlm.nih.gov/pccompound/	https://www.ncbi.nlm.nih.gov/pccompound/	PROPN
admet-854	89	22	http://accelrys.com/	http://accelrys.com/	PROPN
admet-854	89	23	http://autodock.scripps.edu/	http://autodock.scripps.edu/	PROPN
admet-854	89	24	admet	admet	PROPN
admet-854	89	25	&	&	CCONJ
admet-854	89	26	dmpk	dmpk	PROPN
admet-854	89	27	8(2	8(2	NUM
admet-854	89	28	)	)	PUNCT
admet-854	89	29	(	(	PUNCT
admet-854	89	30	2020	2020	NUM
admet-854	89	31	)	)	PUNCT
admet-854	89	32	149	149	NUM
admet-854	89	33	-	-	SYM
admet-854	89	34	175	175	NUM
admet-854	89	35	amantadine	amantadine	NOUN
admet-854	89	36	binding	bind	VERB
admet-854	89	37	to	to	ADP
admet-854	89	38	the	the	DET
admet-854	89	39	enzymes	enzyme	NOUN
admet-854	89	40	regulated	regulate	VERB
admet-854	89	41	in	in	ADP
admet-854	89	42	parkinson	parkinson	NOUN
admet-854	89	43	’s	’s	PART
admet-854	89	44	disease	disease	NOUN
admet-854	89	45	doi	doi	NOUN
admet-854	89	46	:	:	PUNCT
admet-854	89	47	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	89	48	153	153	NUM
admet-854	89	49	number	number	NOUN
admet-854	89	50	of	of	ADP
admet-854	89	51	torsion	torsion	NOUN
admet-854	89	52	and	and	CCONJ
admet-854	89	53	aromaticity	aromaticity	NOUN
admet-854	89	54	criterion	criterion	NOUN
admet-854	89	55	at	at	ADP
admet-854	89	56	7.5	7.5	NUM
admet-854	89	57	’	'	PUNCT
admet-854	89	58	.	.	PUNCT
admet-854	90	1	the	the	DET
admet-854	90	2	searching	searching	NOUN
admet-854	90	3	parameter	parameter	NOUN
admet-854	90	4	was	be	AUX
admet-854	90	5	the	the	DET
admet-854	90	6	lamarckian	lamarckian	ADJ
admet-854	90	7	genetic	genetic	ADJ
admet-854	90	8	algorithm	algorithm	NOUN
admet-854	90	9	(	(	PUNCT
admet-854	90	10	lga	lga	NOUN
admet-854	90	11	)	)	PUNCT
admet-854	90	12	,	,	PUNCT
admet-854	90	13	with	with	ADP
admet-854	90	14	a	a	DET
admet-854	90	15	maximum	maximum	NOUN
admet-854	90	16	of	of	ADP
admet-854	90	17	2,500,000	2,500,000	NUM
admet-854	90	18	energy	energy	NOUN
admet-854	90	19	evaluations	evaluation	NOUN
admet-854	90	20	.	.	PUNCT
admet-854	91	1	other	other	ADJ
admet-854	91	2	docking	dock	VERB
admet-854	91	3	parameters	parameter	NOUN
admet-854	91	4	were	be	AUX
admet-854	91	5	used	use	VERB
admet-854	91	6	as	as	ADP
admet-854	91	7	defaults	default	NOUN
admet-854	91	8	.	.	PUNCT
admet-854	92	1	multiple	multiple	ADJ
admet-854	92	2	sequence	sequence	NOUN
admet-854	92	3	alignment	alignment	NOUN
admet-854	92	4	multiple	multiple	ADJ
admet-854	92	5	sequence	sequence	NOUN
admet-854	92	6	alignment	alignment	NOUN
admet-854	92	7	was	be	AUX
admet-854	92	8	performed	perform	VERB
admet-854	92	9	by	by	ADP
admet-854	92	10	clustal	clustal	ADJ
admet-854	92	11	omega	omega	NOUN
admet-854	92	12	program	program	NOUN
admet-854	92	13	(	(	PUNCT
admet-854	92	14	https://www.ebi.ac.uk/tools/msa/clustalo	https://www.ebi.ac.uk/tools/msa/clustalo	NOUN
admet-854	92	15	)	)	PUNCT
admet-854	92	16	.	.	PUNCT
admet-854	93	1	results	result	NOUN
admet-854	93	2	and	and	CCONJ
admet-854	93	3	discussion	discussion	VERB
admet-854	93	4	the	the	DET
admet-854	93	5	molecular	molecular	ADJ
admet-854	93	6	docking	docking	NOUN
admet-854	93	7	of	of	ADP
admet-854	93	8	aks	ak	NOUN
admet-854	93	9	with	with	ADP
admet-854	93	10	amantadine	amantadine	ADJ
admet-854	93	11	ionized	ionize	VERB
admet-854	93	12	form	form	NOUN
admet-854	93	13	(	(	PUNCT
admet-854	93	14	with	with	ADP
admet-854	93	15	–	–	PUNCT
admet-854	93	16	nh3	nh3	NOUN
admet-854	93	17	+	+	NUM
admet-854	93	18	group	group	NOUN
admet-854	93	19	)	)	PUNCT
admet-854	93	20	and	and	CCONJ
admet-854	93	21	the	the	DET
admet-854	93	22	redocking	redocking	NOUN
admet-854	93	23	experiments	experiment	NOUN
admet-854	93	24	with	with	ADP
admet-854	93	25	substrates	substrate	NOUN
admet-854	93	26	or	or	CCONJ
admet-854	93	27	analog	analog	NOUN
admet-854	93	28	substrates	substrate	NOUN
admet-854	93	29	there	there	PRON
admet-854	93	30	are	be	VERB
admet-854	93	31	nine	nine	NUM
admet-854	93	32	human	human	ADJ
admet-854	93	33	aks	ak	NOUN
admet-854	93	34	isoforms	isoform	NOUN
admet-854	93	35	described	describe	VERB
admet-854	93	36	until	until	ADP
admet-854	93	37	now	now	ADV
admet-854	93	38	,	,	PUNCT
admet-854	93	39	but	but	CCONJ
admet-854	93	40	only	only	ADV
admet-854	93	41	those	those	DET
admet-854	93	42	isoforms	isoform	NOUN
admet-854	93	43	with	with	ADP
admet-854	93	44	x	x	NOUN
admet-854	93	45	-	-	NOUN
admet-854	93	46	ray	ray	ADJ
admet-854	93	47	3d	3d	NOUN
admet-854	93	48	structure	structure	NOUN
admet-854	93	49	solved	solve	VERB
admet-854	93	50	were	be	AUX
admet-854	93	51	further	far	ADV
admet-854	93	52	analyzed	analyze	VERB
admet-854	93	53	by	by	ADP
admet-854	93	54	molecular	molecular	ADJ
admet-854	93	55	docking	docking	NOUN
admet-854	93	56	.	.	PUNCT
admet-854	94	1	the	the	DET
admet-854	94	2	results	result	NOUN
admet-854	94	3	of	of	ADP
admet-854	94	4	human	human	ADJ
admet-854	94	5	aks	ak	NOUN
admet-854	94	6	were	be	AUX
admet-854	94	7	compared	compare	VERB
admet-854	94	8	with	with	ADP
admet-854	94	9	aks	ak	NOUN
admet-854	94	10	from	from	ADP
admet-854	94	11	other	other	ADJ
admet-854	94	12	organisms	organism	NOUN
admet-854	94	13	.	.	PUNCT
admet-854	95	1	the	the	DET
admet-854	95	2	aks	ak	NOUN
admet-854	95	3	with	with	ADP
admet-854	95	4	3d	3d	PROPN
admet-854	95	5	structure	structure	NOUN
admet-854	95	6	co	co	VERB
admet-854	95	7	-	-	VERB
admet-854	95	8	crystallized	crystallize	VERB
admet-854	95	9	with	with	ADP
admet-854	95	10	substrates	substrate	NOUN
admet-854	95	11	or	or	CCONJ
admet-854	95	12	analog	analog	NOUN
admet-854	95	13	substrates	substrate	NOUN
admet-854	95	14	are	be	AUX
admet-854	95	15	optimal	optimal	ADJ
admet-854	95	16	for	for	ADP
admet-854	95	17	our	our	PRON
admet-854	95	18	study	study	NOUN
admet-854	95	19	because	because	SCONJ
admet-854	95	20	the	the	DET
admet-854	95	21	ak	ak	PROPN
admet-854	95	22	is	be	AUX
admet-854	95	23	in	in	ADP
admet-854	95	24	closed	closed	ADJ
admet-854	95	25	-	-	PUNCT
admet-854	95	26	conformation	conformation	NOUN
admet-854	95	27	,	,	PUNCT
admet-854	95	28	with	with	ADP
admet-854	95	29	the	the	DET
admet-854	95	30	flexible	flexible	ADJ
admet-854	95	31	lid	lid	NOUN
admet-854	95	32	domain	domain	NOUN
admet-854	95	33	covering	cover	VERB
admet-854	95	34	the	the	DET
admet-854	95	35	substrate	substrate	NOUN
admet-854	95	36	.	.	PUNCT
admet-854	96	1	because	because	SCONJ
admet-854	96	2	the	the	DET
admet-854	96	3	study	study	NOUN
admet-854	96	4	was	be	AUX
admet-854	96	5	designed	design	VERB
admet-854	96	6	based	base	VERB
admet-854	96	7	on	on	ADP
admet-854	96	8	the	the	DET
admet-854	96	9	aks	ak	NOUN
admet-854	96	10	in	in	ADP
admet-854	96	11	closed	closed	ADJ
admet-854	96	12	-	-	PUNCT
admet-854	96	13	conformation	conformation	NOUN
admet-854	96	14	,	,	PUNCT
admet-854	96	15	the	the	DET
admet-854	96	16	redocking	redocking	NOUN
admet-854	96	17	experiments	experiment	NOUN
admet-854	96	18	of	of	ADP
admet-854	96	19	aks	ak	NOUN
admet-854	96	20	with	with	ADP
admet-854	96	21	its	its	PRON
admet-854	96	22	substrate	substrate	NOUN
admet-854	96	23	or	or	CCONJ
admet-854	96	24	analog	analog	NOUN
admet-854	96	25	substrate	substrate	NOUN
admet-854	96	26	were	be	AUX
admet-854	96	27	performed	perform	VERB
admet-854	96	28	.	.	PUNCT
admet-854	97	1	the	the	DET
admet-854	97	2	energy	energy	NOUN
admet-854	97	3	binding	bind	VERB
admet-854	97	4	(	(	PUNCT
admet-854	97	5	δg	δg	NOUN
admet-854	97	6	)	)	PUNCT
admet-854	97	7	and	and	CCONJ
admet-854	97	8	the	the	DET
admet-854	97	9	inhibition	inhibition	NOUN
admet-854	97	10	constant	constant	ADJ
admet-854	97	11	(	(	PUNCT
admet-854	97	12	ki	ki	INTJ
admet-854	97	13	)	)	PUNCT
admet-854	97	14	of	of	ADP
admet-854	97	15	the	the	DET
admet-854	97	16	best	good	ADJ
admet-854	97	17	conformation	conformation	NOUN
admet-854	97	18	of	of	ADP
admet-854	97	19	the	the	DET
admet-854	97	20	complex	complex	ADJ
admet-854	97	21	ak	ak	NOUN
admet-854	97	22	-	-	PUNCT
admet-854	97	23	amantadine	amantadine	NOUN
admet-854	97	24	and	and	CCONJ
admet-854	97	25	the	the	DET
admet-854	97	26	complex	complex	ADJ
admet-854	97	27	ak	ak	PROPN
admet-854	97	28	-	-	NOUN
admet-854	97	29	ligand	ligand	NOUN
admet-854	97	30	after	after	ADP
admet-854	97	31	redocking	redocke	VERB
admet-854	97	32	allowed	allow	VERB
admet-854	97	33	a	a	DET
admet-854	97	34	first	first	ADJ
admet-854	97	35	view	view	NOUN
admet-854	97	36	of	of	ADP
admet-854	97	37	the	the	DET
admet-854	97	38	interaction	interaction	NOUN
admet-854	97	39	of	of	ADP
admet-854	97	40	amantadine	amantadine	NOUN
admet-854	97	41	with	with	ADP
admet-854	97	42	aks	ak	NOUN
admet-854	97	43	(	(	PUNCT
admet-854	97	44	table	table	NOUN
admet-854	97	45	1	1	NUM
admet-854	97	46	)	)	PUNCT
admet-854	97	47	.	.	PUNCT
admet-854	98	1	table	table	NOUN
admet-854	98	2	1	1	NUM
admet-854	98	3	.	.	PUNCT
admet-854	99	1	the	the	DET
admet-854	99	2	energy	energy	NOUN
admet-854	99	3	binding	bind	VERB
admet-854	99	4	(	(	PUNCT
admet-854	99	5	δg	δg	VERB
admet-854	99	6	)	)	PUNCT
admet-854	99	7	and	and	CCONJ
admet-854	99	8	inhibition	inhibition	VERB
admet-854	99	9	constant	constant	ADJ
admet-854	99	10	(	(	PUNCT
admet-854	99	11	ki	ki	PROPN
admet-854	99	12	)	)	PUNCT
admet-854	99	13	of	of	ADP
admet-854	99	14	the	the	DET
admet-854	99	15	best	good	ADJ
admet-854	99	16	conformation	conformation	NOUN
admet-854	99	17	of	of	ADP
admet-854	99	18	the	the	DET
admet-854	99	19	complex	complex	ADJ
admet-854	99	20	ak	ak	NOUN
admet-854	99	21	amantadine	amantadine	NOUN
admet-854	99	22	and	and	CCONJ
admet-854	99	23	after	after	ADP
admet-854	99	24	redocking	redocke	VERB
admet-854	99	25	.	.	PUNCT
admet-854	100	1	ak	ak	PROPN
admet-854	100	2	pdb	pdb	PROPN
admet-854	101	1	i	i	PROPN
admet-854	101	2	d	d	PROPN
admet-854	101	3	amantadine	amantadine	NOUN
admet-854	101	4	ionized	ionize	VERB
admet-854	101	5	form	form	NOUN
admet-854	101	6	amantadine	amantadine	NOUN
admet-854	101	7	unionized	unionize	VERB
admet-854	101	8	form	form	NOUN
admet-854	101	9	redocking	redocke	VERB
admet-854	101	10	1	1	NUM
admet-854	101	11	δg	δg	PROPN
admet-854	101	12	(	(	PUNCT
admet-854	101	13	kcal	kcal	NOUN
admet-854	101	14	/	/	SYM
admet-854	101	15	mol	mol	NOUN
admet-854	101	16	)	)	PUNCT
admet-854	102	1	ki	ki	PROPN
admet-854	102	2	δg	δg	ADP
admet-854	102	3	(	(	PUNCT
admet-854	102	4	kcal	kcal	PROPN
admet-854	102	5	/	/	SYM
admet-854	102	6	mol	mol	NOUN
admet-854	102	7	)	)	PUNCT
admet-854	103	1	ki	ki	PROPN
admet-854	103	2	δg	δg	ADP
admet-854	103	3	(	(	PUNCT
admet-854	103	4	kcal	kcal	PROPN
admet-854	103	5	/	/	SYM
admet-854	103	6	mol	mol	NOUN
admet-854	103	7	)	)	PUNCT
admet-854	104	1	ki	ki	PROPN
admet-854	104	2	human	human	PROPN
admet-854	104	3	cytosolic	cytosolic	PROPN
admet-854	104	4	aks	ak	NOUN
admet-854	104	5	ak1	ak1	PROPN
admet-854	104	6	2c95	2c95	NUM
admet-854	104	7	-6.19	-6.19	NUM
admet-854	104	8	29.04	29.04	NUM
admet-854	104	9	μm	μm	NOUN
admet-854	104	10	-6.47	-6.47	NUM
admet-854	104	11	18.1	18.1	NUM
admet-854	104	12	μm	μm	NOUN
admet-854	104	13	-10.95	-10.95	NOUN
admet-854	104	14	9.36	9.36	NUM
admet-854	104	15	nm	nm	NOUN
admet-854	104	16	ak2	ak2	NOUN
admet-854	104	17	1z83	1z83	NOUN
admet-854	104	18	-5.97	-5.97	ADP
admet-854	104	19	42.33	42.33	NUM
admet-854	104	20	μm	μm	NOUN
admet-854	104	21	-6.05	-6.05	NUM
admet-854	104	22	36.94	36.94	NUM
admet-854	104	23	μm	μm	NOUN
admet-854	104	24	-11.14	-11.14	NUM
admet-854	104	25	6.87	6.87	NUM
admet-854	104	26	nm	nm	NOUN
admet-854	104	27	ak5	ak5	VERB
admet-854	104	28	2bwj	2bwj	NUM
admet-854	104	29	-6.79	-6.79	NUM
admet-854	104	30	12.61	12.61	NUM
admet-854	104	31	μm	μm	NOUN
admet-854	104	32	-7.03	-7.03	NUM
admet-854	104	33	7.03	7.03	NUM
admet-854	104	34	μm	μm	NOUN
admet-854	104	35	-4.46	-4.46	NUM
admet-854	104	36	534.4	534.4	NUM
admet-854	104	37	μm	μm	NOUN
admet-854	104	38	human	human	ADJ
admet-854	104	39	mitochondrial	mitochondrial	ADJ
admet-854	104	40	aks	ak	NOUN
admet-854	104	41	ak2	ak2	NOUN
admet-854	104	42	2c2y	2c2y	NUM
admet-854	104	43	-6.00	-6.00	NUM
admet-854	104	44	39.68	39.68	NUM
admet-854	104	45	μm	μm	NOUN
admet-854	104	46	-6.25	-6.25	NOUN
admet-854	104	47	26.29	26.29	NUM
admet-854	104	48	μm	μm	NOUN
admet-854	104	49	-7.38	-7.38	NUM
admet-854	104	50	3.91	3.91	NUM
admet-854	104	51	μm	μm	NOUN
admet-854	104	52	ak4	ak4	NOUN
admet-854	104	53	2bbw	2bbw	NUM
admet-854	104	54	not	not	PART
admet-854	104	55	performed	perform	VERB
admet-854	104	56	fail	fail	ADJ
admet-854	104	57	zebrafish	zebrafish	PROPN
admet-854	104	58	ak	ak	PROPN
admet-854	104	59	ak1	ak1	PROPN
admet-854	105	1	5xz2	5xz2	NUM
admet-854	105	2	-5.51	-5.51	NUM
admet-854	106	1	91.53	91.53	NUM
admet-854	106	2	μm	μm	NOUN
admet-854	107	1	-5.69	-5.69	NUM
admet-854	108	1	67.9	67.9	NUM
admet-854	108	2	μm	μm	NUM
admet-854	108	3	-13.2	-13.2	NUM
admet-854	108	4	209.44	209.44	NUM
admet-854	108	5	pm	pm	NOUN
admet-854	108	6	bacterial	bacterial	ADJ
admet-854	108	7	aks	ak	NOUN
admet-854	108	8	e.coli	e.coli	VERB
admet-854	108	9	3hoq	3hoq	NUM
admet-854	108	10	-6.55	-6.55	NUM
admet-854	108	11	15.78	15.78	NUM
admet-854	108	12	μm	μm	NUM
admet-854	108	13	-6.38	-6.38	NUM
admet-854	108	14	21.21	21.21	NUM
admet-854	108	15	μm	μm	NOUN
admet-854	108	16	-5.62	-5.62	NUM
admet-854	108	17	75.52	75.52	NUM
admet-854	108	18	μm	μm	NOUN
admet-854	108	19	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	108	20	1zip	1zip	NUM
admet-854	108	21	-5.87	-5.87	NUM
admet-854	108	22	49.41	49.41	NUM
admet-854	108	23	μm	μm	NOUN
admet-854	109	1	-5.77	-5.77	NUM
admet-854	110	1	59.42	59.42	NUM
admet-854	110	2	μm	μm	NOUN
admet-854	110	3	-7.2	-7.2	NUM
admet-854	110	4	5.3	5.3	NUM
admet-854	110	5	μm	μm	NUM
admet-854	110	6	1	1	NUM
admet-854	110	7	redocking	redocke	VERB
admet-854	110	8	with	with	ADP
admet-854	110	9	the	the	DET
admet-854	110	10	substrates	substrate	NOUN
admet-854	110	11	co	co	VERB
admet-854	110	12	-	-	VERB
admet-854	110	13	crystallized	crystallized	ADJ
admet-854	110	14	in	in	ADP
admet-854	110	15	pdb	pdb	PROPN
admet-854	110	16	x	x	PROPN
admet-854	110	17	-	-	NOUN
admet-854	110	18	ray	ray	NOUN
admet-854	110	19	3d	3d	PROPN
admet-854	110	20	structures	structure	NOUN
admet-854	110	21	.	.	PUNCT
admet-854	111	1	redoking	redoking	NOUN
admet-854	111	2	of	of	ADP
admet-854	111	3	the	the	DET
admet-854	111	4	aks	ak	NOUN
admet-854	111	5	isoforms	isoform	NOUN
admet-854	111	6	with	with	ADP
admet-854	111	7	the	the	DET
admet-854	111	8	substrates	substrate	NOUN
admet-854	111	9	co	co	VERB
admet-854	111	10	-	-	VERB
admet-854	111	11	crystallized	crystallized	ADJ
admet-854	111	12	in	in	ADP
admet-854	111	13	the	the	DET
admet-854	111	14	x	x	NOUN
admet-854	111	15	-	-	NOUN
admet-854	111	16	ray	ray	ADJ
admet-854	111	17	3d	3d	PROPN
admet-854	111	18	structures	structure	VERB
admet-854	111	19	the	the	DET
admet-854	111	20	redocking	redocking	NOUN
admet-854	111	21	process	process	NOUN
admet-854	111	22	allows	allow	VERB
admet-854	111	23	verifying	verify	VERB
admet-854	111	24	the	the	DET
admet-854	111	25	docking	docking	NOUN
admet-854	111	26	parameters	parameter	NOUN
admet-854	111	27	.	.	PUNCT
admet-854	112	1	because	because	SCONJ
admet-854	112	2	the	the	DET
admet-854	112	3	ak	ak	PROPN
admet-854	112	4	undergoes	undergoe	NOUN
admet-854	112	5	conformational	conformational	ADJ
admet-854	112	6	changes	change	NOUN
admet-854	112	7	during	during	ADP
admet-854	112	8	catalysis	catalysis	NOUN
admet-854	112	9	,	,	PUNCT
admet-854	112	10	the	the	DET
admet-854	112	11	substrate	substrate	NOUN
admet-854	112	12	does	do	AUX
admet-854	112	13	not	not	PART
admet-854	112	14	perfectly	perfectly	ADV
admet-854	112	15	fit	fit	ADJ
admet-854	112	16	with	with	ADP
admet-854	112	17	the	the	DET
admet-854	112	18	pdb	pdb	PROPN
admet-854	112	19	conformation	conformation	NOUN
admet-854	112	20	on	on	ADP
admet-854	112	21	redocking	redocke	VERB
admet-854	112	22	experiments	experiment	NOUN
admet-854	112	23	.	.	PUNCT
admet-854	113	1	one	one	NUM
admet-854	113	2	explanation	explanation	NOUN
admet-854	113	3	is	be	AUX
admet-854	113	4	that	that	SCONJ
admet-854	113	5	the	the	DET
admet-854	113	6	crystal	crystal	NOUN
admet-854	113	7	structure	structure	NOUN
admet-854	113	8	was	be	AUX
admet-854	113	9	solved	solve	VERB
admet-854	113	10	by	by	ADP
admet-854	113	11	an	an	DET
admet-854	113	12	analog	analog	NOUN
admet-854	113	13	substrate	substrate	NOUN
admet-854	113	14	,	,	PUNCT
admet-854	113	15	not	not	PART
admet-854	113	16	by	by	ADP
admet-854	113	17	the	the	DET
admet-854	113	18	amp	amp	PROPN
admet-854	113	19	and	and	CCONJ
admet-854	113	20	atp	atp	PROPN
admet-854	113	21	.	.	PUNCT
admet-854	114	1	the	the	DET
admet-854	114	2	flexibility	flexibility	NOUN
admet-854	114	3	of	of	ADP
admet-854	114	4	the	the	DET
admet-854	114	5	ak	ak	PROPN
admet-854	114	6	is	be	AUX
admet-854	114	7	very	very	ADV
admet-854	114	8	well	well	ADV
admet-854	114	9	studied	study	VERB
admet-854	114	10	.	.	PUNCT
admet-854	115	1	during	during	ADP
admet-854	115	2	the	the	DET
admet-854	115	3	phosphoryl	phosphoryl	NOUN
admet-854	115	4	transfer	transfer	NOUN
admet-854	115	5	,	,	PUNCT
admet-854	115	6	the	the	DET
admet-854	115	7	two	two	NUM
admet-854	115	8	small	small	ADJ
admet-854	115	9	peripheral	peripheral	ADJ
admet-854	115	10	domains	domain	NOUN
admet-854	115	11	of	of	ADP
admet-854	115	12	the	the	DET
admet-854	115	13	ak	ak	PROPN
admet-854	115	14	(	(	PUNCT
admet-854	115	15	nmb	nmb	NOUN
admet-854	115	16	binding	bind	VERB
admet-854	115	17	domain	domain	NOUN
admet-854	115	18	and	and	CCONJ
admet-854	115	19	lid	lid	NOUN
admet-854	115	20	domain	domain	NOUN
admet-854	115	21	)	)	PUNCT
admet-854	115	22	move	move	VERB
admet-854	115	23	to	to	PART
admet-854	115	24	close	close	VERB
admet-854	115	25	the	the	DET
admet-854	115	26	atp	atp	NOUN
admet-854	115	27	binding	bind	VERB
admet-854	115	28	region	region	NOUN
admet-854	115	29	.	.	PUNCT
admet-854	116	1	the	the	DET
admet-854	116	2	amp	amp	NOUN
admet-854	116	3	is	be	AUX
admet-854	116	4	tightly	tightly	ADV
admet-854	116	5	bound	bind	VERB
admet-854	116	6	to	to	ADP
admet-854	116	7	the	the	DET
admet-854	116	8	amp	amp	NOUN
admet-854	116	9	site	site	NOUN
admet-854	116	10	when	when	SCONJ
admet-854	116	11	the	the	DET
admet-854	116	12	amp	amp	NOUN
admet-854	116	13	domain	domain	NOUN
admet-854	116	14	undergoes	undergo	VERB
admet-854	116	15	minor	minor	ADJ
admet-854	116	16	movements	movement	NOUN
admet-854	116	17	.	.	PUNCT
admet-854	117	1	contrary	contrary	ADJ
admet-854	117	2	,	,	PUNCT
admet-854	117	3	when	when	SCONJ
admet-854	117	4	the	the	DET
admet-854	117	5	atp	atp	NOUN
admet-854	117	6	loosely	loosely	ADV
admet-854	117	7	bounds	bound	VERB
admet-854	117	8	to	to	ADP
admet-854	117	9	the	the	DET
admet-854	117	10	atp	atp	PROPN
admet-854	117	11	site	site	NOUN
admet-854	117	12	,	,	PUNCT
admet-854	117	13	the	the	DET
admet-854	117	14	large	large	ADJ
admet-854	117	15	movements	movement	NOUN
admet-854	117	16	of	of	ADP
admet-854	117	17	the	the	DET
admet-854	117	18	lid	lid	NOUN
admet-854	117	19	domain	domain	NOUN
admet-854	117	20	occurs	occur	VERB
admet-854	117	21	–	–	PUNCT
admet-854	117	22	~30	~30	X
admet-854	117	23	°	°	ADP
admet-854	117	24	c	c	NOUN
admet-854	117	25	and	and	CCONJ
admet-854	117	26	88	88	NUM
admet-854	117	27	°	°	NUM
admet-854	117	28	hinge	hinge	NOUN
admet-854	117	29	bending	bend	VERB
admet-854	117	30	rotation	rotation	NOUN
admet-854	117	31	–	–	PUNCT
admet-854	117	32	then	then	ADV
admet-854	117	33	the	the	DET
admet-854	117	34	lid	lid	NOUN
admet-854	117	35	domain	domain	NOUN
admet-854	117	36	closed	close	VERB
admet-854	117	37	tightly	tightly	ADV
admet-854	117	38	upon	upon	SCONJ
admet-854	117	39	atp	atp	PROPN
admet-854	117	40	[	[	X
admet-854	117	41	56	56	NUM
admet-854	117	42	]	]	PUNCT
admet-854	117	43	.	.	PUNCT
admet-854	118	1	however	however	ADV
admet-854	118	2	,	,	PUNCT
admet-854	118	3	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	118	4	https://www.ebi.ac.uk/tools/msa/clustalo	https://www.ebi.ac.uk/tools/msa/clustalo	X
admet-854	119	1	https://www.ebi.ac.uk/tools/msa/clustalo	https://www.ebi.ac.uk/tools/msa/clustalo	X
admet-854	119	2	mihaela	mihaela	PROPN
admet-854	119	3	ileana	ileana	PROPN
admet-854	119	4	ionescu	ionescu	PROPN
admet-854	119	5	admet	admet	PROPN
admet-854	119	6	&	&	CCONJ
admet-854	119	7	dmpk	dmpk	PROPN
admet-854	119	8	8(2	8(2	NUM
admet-854	119	9	)	)	PUNCT
admet-854	119	10	(	(	PUNCT
admet-854	119	11	2020	2020	NUM
admet-854	119	12	)	)	PUNCT
admet-854	119	13	149	149	NUM
admet-854	119	14	-	-	SYM
admet-854	119	15	175	175	NUM
admet-854	119	16	154	154	NUM
admet-854	119	17	observing	observe	VERB
admet-854	119	18	the	the	DET
admet-854	119	19	redocked	redocke	VERB
admet-854	119	20	conformations	conformation	NOUN
admet-854	119	21	permits	permit	VERB
admet-854	119	22	the	the	DET
admet-854	119	23	chosen	choose	VERB
admet-854	119	24	of	of	ADP
admet-854	119	25	the	the	DET
admet-854	119	26	most	most	ADV
admet-854	119	27	suitable	suitable	ADJ
admet-854	119	28	3d	3d	NUM
admet-854	119	29	structure	structure	NOUN
admet-854	119	30	when	when	SCONJ
admet-854	119	31	two	two	NUM
admet-854	119	32	closed	close	VERB
admet-854	119	33	-	-	PUNCT
admet-854	119	34	conformation	conformation	NOUN
admet-854	119	35	of	of	ADP
admet-854	119	36	the	the	DET
admet-854	119	37	same	same	ADJ
admet-854	119	38	enzyme	enzyme	NOUN
admet-854	119	39	,	,	PUNCT
admet-854	119	40	co	co	VERB
admet-854	119	41	-	-	VERB
admet-854	119	42	crystallized	crystallize	VERB
admet-854	119	43	with	with	ADP
admet-854	119	44	different	different	ADJ
admet-854	119	45	substrates	substrate	NOUN
admet-854	119	46	or	or	CCONJ
admet-854	119	47	analog	analog	NOUN
admet-854	119	48	substrates	substrate	NOUN
admet-854	119	49	,	,	PUNCT
admet-854	119	50	was	be	AUX
admet-854	119	51	found	find	VERB
admet-854	119	52	in	in	ADP
admet-854	119	53	pdb	pdb	PROPN
admet-854	119	54	.	.	PUNCT
admet-854	120	1	this	this	PRON
admet-854	120	2	is	be	AUX
admet-854	120	3	the	the	DET
admet-854	120	4	case	case	NOUN
admet-854	120	5	of	of	ADP
admet-854	120	6	ak	ak	PROPN
admet-854	120	7	isoform	isoform	NOUN
admet-854	120	8	1	1	NUM
admet-854	120	9	for	for	ADP
admet-854	120	10	which	which	PRON
admet-854	120	11	there	there	PRON
admet-854	120	12	are	be	VERB
admet-854	120	13	three	three	NUM
admet-854	120	14	closed	closed	ADJ
admet-854	120	15	-	-	PUNCT
admet-854	120	16	conformation	conformation	NOUN
admet-854	120	17	structures	structure	NOUN
admet-854	120	18	–	–	PUNCT
admet-854	120	19	two	two	NUM
admet-854	120	20	for	for	ADP
admet-854	120	21	human	human	ADJ
admet-854	120	22	enzyme	enzyme	NOUN
admet-854	120	23	and	and	CCONJ
admet-854	120	24	one	one	NUM
admet-854	120	25	for	for	ADP
admet-854	120	26	zebrafish	zebrafish	ADJ
admet-854	120	27	counterpart	counterpart	NOUN
admet-854	120	28	.	.	PUNCT
admet-854	121	1	the	the	DET
admet-854	121	2	best	well	ADV
admet-854	121	3	redocked	redocke	VERB
admet-854	121	4	conformations	conformation	NOUN
admet-854	121	5	are	be	AUX
admet-854	121	6	for	for	ADP
admet-854	121	7	the	the	DET
admet-854	121	8	aks	ak	NOUN
admet-854	121	9	co	co	NOUN
admet-854	121	10	-	-	VERB
admet-854	121	11	crystallized	crystallize	VERB
admet-854	121	12	with	with	ADP
admet-854	121	13	bis(adenosine)-5’-pentaphosphate	bis(adenosine)-5’-pentaphosphate	PROPN
admet-854	121	14	(	(	PUNCT
admet-854	121	15	ap5a	ap5a	PROPN
admet-854	121	16	)	)	PUNCT
admet-854	121	17	–	–	PUNCT
admet-854	121	18	1x83	1x83	NUM
admet-854	121	19	and	and	CCONJ
admet-854	121	20	5xz2	5xz2	NUM
admet-854	121	21	(	(	PUNCT
admet-854	121	22	figure	figure	NOUN
admet-854	121	23	1	1	NUM
admet-854	121	24	)	)	PUNCT
admet-854	121	25	.	.	PUNCT
admet-854	122	1	the	the	DET
admet-854	122	2	availability	availability	NOUN
admet-854	122	3	of	of	ADP
admet-854	122	4	three	three	NUM
admet-854	122	5	different	different	ADJ
admet-854	122	6	conformation	conformation	NOUN
admet-854	122	7	of	of	ADP
admet-854	122	8	the	the	DET
admet-854	122	9	ak1	ak1	NOUN
admet-854	122	10	–	–	PUNCT
admet-854	122	11	an	an	DET
admet-854	122	12	ak	ak	PROPN
admet-854	122	13	isoform	isoform	NOUN
admet-854	122	14	dysregulated	dysregulate	VERB
admet-854	122	15	in	in	ADP
admet-854	122	16	pd	pd	PROPN
admet-854	122	17	–	–	PUNCT
admet-854	122	18	provides	provide	VERB
admet-854	122	19	a	a	DET
admet-854	122	20	substantial	substantial	ADJ
admet-854	122	21	advantage	advantage	NOUN
admet-854	122	22	for	for	ADP
admet-854	122	23	further	further	ADJ
admet-854	122	24	analyses	analysis	NOUN
admet-854	122	25	.	.	PUNCT
admet-854	123	1	(	(	PUNCT
admet-854	123	2	a	a	X
admet-854	123	3	)	)	PUNCT
admet-854	123	4	5xz2	5xz2	NUM
admet-854	123	5	(	(	PUNCT
admet-854	123	6	zebrafish	zebrafish	PROPN
admet-854	123	7	ak1	ak1	NOUN
admet-854	123	8	)	)	PUNCT
admet-854	123	9	(	(	PUNCT
admet-854	123	10	b	b	X
admet-854	123	11	)	)	PUNCT
admet-854	123	12	1x83	1x83	PROPN
admet-854	123	13	(	(	PUNCT
admet-854	123	14	human	human	PROPN
admet-854	123	15	ak1	ak1	PROPN
admet-854	123	16	)	)	PUNCT
admet-854	123	17	(	(	PUNCT
admet-854	123	18	c	c	X
admet-854	123	19	)	)	PUNCT
admet-854	123	20	2c95	2c95	NOUN
admet-854	123	21	(	(	PUNCT
admet-854	123	22	human	human	PROPN
admet-854	123	23	ak1	ak1	NOUN
admet-854	123	24	)	)	PUNCT
admet-854	123	25	figure	figure	NOUN
admet-854	123	26	1	1	NUM
admet-854	123	27	.	.	PUNCT
admet-854	124	1	the	the	DET
admet-854	124	2	comparative	comparative	ADJ
admet-854	124	3	interactions	interaction	NOUN
admet-854	124	4	of	of	ADP
admet-854	124	5	the	the	DET
admet-854	124	6	ak1	ak1	NOUN
admet-854	124	7	isoforms	isoform	NOUN
admet-854	124	8	with	with	ADP
admet-854	124	9	the	the	DET
admet-854	124	10	analog	analog	NOUN
admet-854	124	11	substrates	substrate	NOUN
admet-854	124	12	(	(	PUNCT
admet-854	124	13	ap5a	ap5a	PROPN
admet-854	124	14	or	or	CCONJ
admet-854	124	15	b4p	b4p	NOUN
admet-854	124	16	)	)	PUNCT
admet-854	124	17	after	after	ADP
admet-854	124	18	redocking	redocke	VERB
admet-854	124	19	.	.	PUNCT
admet-854	125	1	the	the	DET
admet-854	125	2	redocked	redocke	VERB
admet-854	125	3	conformations	conformation	NOUN
admet-854	125	4	are	be	AUX
admet-854	125	5	shown	show	VERB
admet-854	125	6	in	in	ADP
admet-854	125	7	yellow	yellow	ADJ
admet-854	125	8	.	.	PUNCT
admet-854	126	1	(	(	PUNCT
admet-854	126	2	a	a	X
admet-854	126	3	)	)	PUNCT
admet-854	126	4	zebrafish	zebrafish	ADJ
admet-854	126	5	ak1	ak1	NOUN
admet-854	126	6	(	(	PUNCT
admet-854	126	7	pdb	pdb	PROPN
admet-854	126	8	i	i	PROPN
admet-854	126	9	d	d	PROPN
admet-854	126	10	5xz2	5xz2	NUM
admet-854	126	11	)	)	PUNCT
admet-854	126	12	;	;	PUNCT
admet-854	126	13	(	(	PUNCT
admet-854	126	14	b	b	X
admet-854	126	15	)	)	PUNCT
admet-854	126	16	human	human	ADJ
admet-854	126	17	ak1	ak1	PROPN
admet-854	126	18	(	(	PUNCT
admet-854	126	19	pdb	pdb	PROPN
admet-854	126	20	i	i	PROPN
admet-854	126	21	d	d	PROPN
admet-854	126	22	1x83	1x83	NUM
admet-854	126	23	)	)	PUNCT
admet-854	126	24	;	;	PUNCT
admet-854	126	25	(	(	PUNCT
admet-854	126	26	c	c	X
admet-854	126	27	)	)	PUNCT
admet-854	126	28	human	human	ADJ
admet-854	126	29	ak1	ak1	PROPN
admet-854	126	30	(	(	PUNCT
admet-854	126	31	pdb	pdb	PROPN
admet-854	126	32	i	i	NOUN
admet-854	126	33	d	d	PROPN
admet-854	126	34	2c95	2c95	NUM
admet-854	126	35	)	)	PUNCT
admet-854	126	36	.	.	PUNCT
admet-854	127	1	the	the	DET
admet-854	127	2	human	human	ADJ
admet-854	127	3	ak2	ak2	PROPN
admet-854	127	4	isoform	isoform	NOUN
admet-854	127	5	(	(	PUNCT
admet-854	127	6	pdb	pdb	PROPN
admet-854	127	7	i	i	PROPN
admet-854	127	8	d	d	PROPN
admet-854	127	9	2c9y	2c9y	PROPN
admet-854	127	10	)	)	PUNCT
admet-854	127	11	is	be	AUX
admet-854	127	12	found	find	VERB
admet-854	127	13	in	in	ADP
admet-854	127	14	closed	closed	ADJ
admet-854	127	15	-	-	PUNCT
admet-854	127	16	conformation	conformation	NOUN
admet-854	127	17	only	only	ADV
admet-854	127	18	co	co	VERB
admet-854	127	19	-	-	VERB
admet-854	127	20	crystallized	crystallize	VERB
admet-854	127	21	with	with	ADP
admet-854	127	22	p1	p1	PROPN
admet-854	127	23	,	,	PUNCT
admet-854	127	24	p4di(adenosine)tetraphosphate	p4di(adenosine)tetraphosphate	PROPN
admet-854	127	25	(	(	PUNCT
admet-854	127	26	b4p	b4p	NOUN
admet-854	127	27	)	)	PUNCT
admet-854	127	28	.	.	PUNCT
admet-854	128	1	the	the	DET
admet-854	128	2	redocking	redocking	NOUN
admet-854	128	3	of	of	ADP
admet-854	128	4	the	the	DET
admet-854	128	5	b4p	b4p	NOUN
admet-854	128	6	substrate	substrate	NOUN
admet-854	128	7	as	as	ADP
admet-854	128	8	ligand	ligand	NOUN
admet-854	128	9	demonstrate	demonstrate	VERB
admet-854	128	10	that	that	SCONJ
admet-854	128	11	the	the	DET
admet-854	128	12	parameters	parameter	NOUN
admet-854	128	13	specified	specify	VERB
admet-854	128	14	in	in	ADP
admet-854	128	15	the	the	DET
admet-854	128	16	docking	docking	NOUN
admet-854	128	17	method	method	NOUN
admet-854	128	18	are	be	AUX
admet-854	128	19	reasonable	reasonable	ADJ
admet-854	128	20	even	even	ADV
admet-854	128	21	there	there	PRON
admet-854	128	22	is	be	VERB
admet-854	128	23	not	not	PART
admet-854	128	24	a	a	DET
admet-854	128	25	perfect	perfect	ADJ
admet-854	128	26	match	match	NOUN
admet-854	128	27	with	with	ADP
admet-854	128	28	the	the	DET
admet-854	128	29	xray	xray	PROPN
admet-854	128	30	3d	3d	NUM
admet-854	128	31	structure	structure	NOUN
admet-854	128	32	from	from	ADP
admet-854	128	33	the	the	DET
admet-854	128	34	pdb	pdb	PROPN
admet-854	128	35	(	(	PUNCT
admet-854	128	36	figure	figure	NOUN
admet-854	128	37	2a	2a	NUM
admet-854	128	38	)	)	PUNCT
admet-854	128	39	.	.	PUNCT
admet-854	129	1	the	the	DET
admet-854	129	2	human	human	ADJ
admet-854	129	3	ak5	ak5	NOUN
admet-854	129	4	isoform	isoform	NOUN
admet-854	129	5	(	(	PUNCT
admet-854	129	6	pdb	pdb	PROPN
admet-854	129	7	i	i	PROPN
admet-854	129	8	d	d	PROPN
admet-854	129	9	2bwj	2bwj	NUM
admet-854	129	10	)	)	PUNCT
admet-854	129	11	is	be	AUX
admet-854	129	12	deposed	depose	VERB
admet-854	129	13	in	in	ADP
admet-854	129	14	pdb	pdb	PROPN
admet-854	129	15	only	only	ADV
admet-854	129	16	co	co	VERB
admet-854	129	17	-	-	VERB
admet-854	129	18	crystallized	crystallize	VERB
admet-854	129	19	with	with	ADP
admet-854	129	20	one	one	NUM
admet-854	129	21	substrate	substrate	NOUN
admet-854	129	22	–	–	PUNCT
admet-854	129	23	amp	amp	NOUN
admet-854	129	24	.	.	PUNCT
admet-854	130	1	therefore	therefore	ADV
admet-854	130	2	,	,	PUNCT
admet-854	130	3	the	the	DET
admet-854	130	4	enzyme	enzyme	NOUN
admet-854	130	5	is	be	AUX
admet-854	130	6	in	in	ADP
admet-854	130	7	semi	semi	ADJ
admet-854	130	8	closed	closed	ADJ
admet-854	130	9	-	-	PUNCT
admet-854	130	10	conformation	conformation	NOUN
admet-854	130	11	.	.	PUNCT
admet-854	131	1	the	the	DET
admet-854	131	2	redocking	redocking	NOUN
admet-854	131	3	of	of	ADP
admet-854	131	4	the	the	DET
admet-854	131	5	amp	amp	NOUN
admet-854	131	6	does	do	AUX
admet-854	131	7	not	not	PART
admet-854	131	8	show	show	VERB
admet-854	131	9	the	the	DET
admet-854	131	10	same	same	ADJ
admet-854	131	11	interactions	interaction	NOUN
admet-854	131	12	as	as	ADP
admet-854	131	13	the	the	DET
admet-854	131	14	x	x	NOUN
admet-854	131	15	-	-	NOUN
admet-854	131	16	ray	ray	ADJ
admet-854	131	17	3d	3d	NOUN
admet-854	131	18	structure	structure	NOUN
admet-854	131	19	deposed	depose	VERB
admet-854	131	20	in	in	ADP
admet-854	131	21	pdb	pdb	PROPN
admet-854	131	22	(	(	PUNCT
admet-854	131	23	figure	figure	NOUN
admet-854	131	24	2b	2b	NOUN
admet-854	131	25	)	)	PUNCT
admet-854	131	26	.	.	PUNCT
admet-854	132	1	the	the	DET
admet-854	132	2	explanation	explanation	NOUN
admet-854	132	3	could	could	AUX
admet-854	132	4	reside	reside	VERB
admet-854	132	5	in	in	ADP
admet-854	132	6	the	the	DET
admet-854	132	7	semi	semi	ADJ
admet-854	132	8	closed	closed	ADJ
admet-854	132	9	-	-	PUNCT
admet-854	132	10	conformation	conformation	NOUN
admet-854	132	11	of	of	ADP
admet-854	132	12	the	the	DET
admet-854	132	13	2bwj	2bwj	NOUN
admet-854	132	14	–	–	PUNCT
admet-854	132	15	the	the	DET
admet-854	132	16	3d	3d	NOUN
admet-854	132	17	structure	structure	NOUN
admet-854	132	18	contains	contain	VERB
admet-854	132	19	only	only	ADV
admet-854	132	20	one	one	NUM
admet-854	132	21	substrate	substrate	NOUN
admet-854	132	22	amp	amp	NOUN
admet-854	132	23	,	,	PUNCT
admet-854	132	24	the	the	DET
admet-854	132	25	substrate	substrate	NOUN
admet-854	132	26	that	that	PRON
admet-854	132	27	causes	cause	VERB
admet-854	132	28	minor	minor	ADJ
admet-854	132	29	movements	movement	NOUN
admet-854	132	30	of	of	ADP
admet-854	132	31	the	the	DET
admet-854	132	32	amp	amp	NOUN
admet-854	132	33	domain	domain	NOUN
admet-854	132	34	[	[	X
admet-854	132	35	56	56	NUM
admet-854	132	36	]	]	PUNCT
admet-854	132	37	.	.	PUNCT
admet-854	133	1	the	the	DET
admet-854	133	2	semi	semi	ADJ
admet-854	133	3	-	-	ADJ
admet-854	133	4	closed	closed	ADJ
admet-854	133	5	conformation	conformation	NOUN
admet-854	133	6	of	of	ADP
admet-854	133	7	the	the	DET
admet-854	133	8	human	human	ADJ
admet-854	133	9	ak5	ak5	NOUN
admet-854	133	10	is	be	AUX
admet-854	133	11	one	one	NUM
admet-854	133	12	limitation	limitation	NOUN
admet-854	133	13	of	of	ADP
admet-854	133	14	the	the	DET
admet-854	133	15	present	present	ADJ
admet-854	133	16	study	study	NOUN
admet-854	133	17	,	,	PUNCT
admet-854	133	18	which	which	PRON
admet-854	133	19	relies	rely	VERB
admet-854	133	20	on	on	ADP
admet-854	133	21	the	the	DET
admet-854	133	22	x	x	NOUN
admet-854	133	23	-	-	NOUN
admet-854	133	24	ray	ray	ADJ
admet-854	133	25	3d	3d	NUM
admet-854	133	26	structure	structure	NOUN
admet-854	133	27	on	on	ADP
admet-854	133	28	closed	closed	ADJ
admet-854	133	29	-	-	PUNCT
admet-854	133	30	conformation	conformation	NOUN
admet-854	133	31	.	.	PUNCT
admet-854	134	1	(	(	PUNCT
admet-854	134	2	a	a	X
admet-854	134	3	)	)	PUNCT
admet-854	134	4	2c9y	2c9y	NOUN
admet-854	134	5	(	(	PUNCT
admet-854	134	6	human	human	ADJ
admet-854	134	7	ak2	ak2	NOUN
admet-854	134	8	)	)	PUNCT
admet-854	134	9	(	(	PUNCT
admet-854	134	10	b	b	X
admet-854	134	11	)	)	PUNCT
admet-854	134	12	2bwj	2bwj	PROPN
admet-854	134	13	(	(	PUNCT
admet-854	134	14	human	human	ADJ
admet-854	134	15	ak5	ak5	NOUN
admet-854	134	16	)	)	PUNCT
admet-854	134	17	figure	figure	NOUN
admet-854	134	18	2	2	NUM
admet-854	134	19	.	.	PUNCT
admet-854	135	1	(	(	PUNCT
admet-854	135	2	a	a	X
admet-854	135	3	)	)	PUNCT
admet-854	135	4	the	the	DET
admet-854	135	5	interactions	interaction	NOUN
admet-854	135	6	comparative	comparative	ADJ
admet-854	135	7	of	of	ADP
admet-854	135	8	the	the	DET
admet-854	135	9	human	human	ADJ
admet-854	135	10	ak2	ak2	NOUN
admet-854	135	11	(	(	PUNCT
admet-854	135	12	pdb	pdb	PROPN
admet-854	135	13	i	i	PROPN
admet-854	135	14	d	d	PROPN
admet-854	135	15	2c9y	2c9y	PROPN
admet-854	135	16	)	)	PUNCT
admet-854	135	17	with	with	ADP
admet-854	135	18	the	the	DET
admet-854	135	19	b4p	b4p	NOUN
admet-854	135	20	after	after	ADP
admet-854	135	21	redocking	redocke	VERB
admet-854	135	22	;	;	PUNCT
admet-854	135	23	(	(	PUNCT
admet-854	135	24	b	b	X
admet-854	135	25	)	)	PUNCT
admet-854	135	26	the	the	DET
admet-854	135	27	comparative	comparative	ADJ
admet-854	135	28	interactions	interaction	NOUN
admet-854	135	29	of	of	ADP
admet-854	135	30	the	the	DET
admet-854	135	31	human	human	ADJ
admet-854	135	32	ak5	ak5	NOUN
admet-854	135	33	(	(	PUNCT
admet-854	135	34	pdb	pdb	PROPN
admet-854	135	35	i	i	PROPN
admet-854	135	36	d	d	PROPN
admet-854	135	37	2bwj	2bwj	NUM
admet-854	135	38	)	)	PUNCT
admet-854	135	39	with	with	ADP
admet-854	135	40	the	the	DET
admet-854	135	41	amp	amp	NOUN
admet-854	135	42	after	after	ADP
admet-854	135	43	redocking	redocke	VERB
admet-854	135	44	.	.	PUNCT
admet-854	136	1	the	the	DET
admet-854	136	2	redocked	redocke	VERB
admet-854	136	3	conformations	conformation	NOUN
admet-854	136	4	are	be	AUX
admet-854	136	5	shown	show	VERB
admet-854	136	6	in	in	ADP
admet-854	136	7	yellow	yellow	ADJ
admet-854	136	8	.	.	PUNCT
admet-854	137	1	admet	admet	PROPN
admet-854	137	2	&	&	CCONJ
admet-854	137	3	dmpk	dmpk	PROPN
admet-854	137	4	8(2	8(2	NUM
admet-854	137	5	)	)	PUNCT
admet-854	137	6	(	(	PUNCT
admet-854	137	7	2020	2020	NUM
admet-854	137	8	)	)	PUNCT
admet-854	137	9	149	149	NUM
admet-854	137	10	-	-	SYM
admet-854	137	11	175	175	NUM
admet-854	137	12	amantadine	amantadine	NOUN
admet-854	137	13	binding	bind	VERB
admet-854	137	14	to	to	ADP
admet-854	137	15	the	the	DET
admet-854	137	16	enzymes	enzyme	NOUN
admet-854	137	17	regulated	regulate	VERB
admet-854	137	18	in	in	ADP
admet-854	137	19	parkinson	parkinson	NOUN
admet-854	137	20	’s	’s	PART
admet-854	137	21	disease	disease	NOUN
admet-854	137	22	doi	doi	NOUN
admet-854	137	23	:	:	PUNCT
admet-854	137	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	137	25	155	155	NUM
admet-854	137	26	the	the	DET
admet-854	137	27	redocking	redocking	NOUN
admet-854	137	28	of	of	ADP
admet-854	137	29	the	the	DET
admet-854	137	30	analog	analog	NOUN
admet-854	137	31	substrate	substrate	NOUN
admet-854	137	32	ap5a	ap5a	PROPN
admet-854	137	33	as	as	ADP
admet-854	137	34	a	a	DET
admet-854	137	35	ligand	ligand	NOUN
admet-854	137	36	with	with	ADP
admet-854	137	37	aks	ak	NOUN
admet-854	137	38	from	from	ADP
admet-854	137	39	e.coli	e.coli	NOUN
admet-854	137	40	and	and	CCONJ
admet-854	137	41	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	137	42	does	do	AUX
admet-854	137	43	not	not	PART
admet-854	137	44	perfectly	perfectly	ADV
admet-854	137	45	match	match	VERB
admet-854	137	46	with	with	ADP
admet-854	137	47	the	the	DET
admet-854	137	48	conformation	conformation	NOUN
admet-854	137	49	of	of	ADP
admet-854	137	50	the	the	DET
admet-854	137	51	ap5a	ap5a	PROPN
admet-854	137	52	from	from	ADP
admet-854	137	53	the	the	DET
admet-854	137	54	x	x	NOUN
admet-854	137	55	-	-	NOUN
admet-854	137	56	ray	ray	ADJ
admet-854	137	57	3d	3d	NOUN
admet-854	137	58	structure	structure	NOUN
admet-854	137	59	deposed	depose	VERB
admet-854	137	60	in	in	ADP
admet-854	137	61	pdb	pdb	PROPN
admet-854	137	62	(	(	PUNCT
admet-854	137	63	figure	figure	NOUN
admet-854	137	64	3	3	NUM
admet-854	137	65	)	)	PUNCT
admet-854	137	66	.	.	PUNCT
admet-854	138	1	despite	despite	SCONJ
admet-854	138	2	this	this	DET
admet-854	138	3	limitation	limitation	NOUN
admet-854	138	4	,	,	PUNCT
admet-854	138	5	the	the	DET
admet-854	138	6	closed	close	VERB
admet-854	138	7	-	-	PUNCT
admet-854	138	8	conformation	conformation	NOUN
admet-854	138	9	of	of	ADP
admet-854	138	10	ak	ak	PROPN
admet-854	138	11	is	be	AUX
admet-854	138	12	the	the	DET
admet-854	138	13	best	good	ADJ
admet-854	138	14	choice	choice	NOUN
admet-854	138	15	when	when	SCONJ
admet-854	138	16	performing	perform	VERB
admet-854	138	17	molecular	molecular	ADJ
admet-854	138	18	studies	study	NOUN
admet-854	138	19	involving	involve	VERB
admet-854	138	20	this	this	DET
admet-854	138	21	enzyme	enzyme	NOUN
admet-854	138	22	.	.	PUNCT
admet-854	139	1	furthermore	furthermore	ADV
admet-854	139	2	,	,	PUNCT
admet-854	139	3	the	the	DET
admet-854	139	4	present	present	ADJ
admet-854	139	5	study	study	NOUN
admet-854	139	6	’s	’s	PART
admet-854	139	7	results	result	NOUN
admet-854	139	8	allow	allow	VERB
admet-854	139	9	the	the	DET
admet-854	139	10	comparison	comparison	NOUN
admet-854	139	11	of	of	ADP
admet-854	139	12	the	the	DET
admet-854	139	13	interaction	interaction	NOUN
admet-854	139	14	of	of	ADP
admet-854	139	15	the	the	DET
admet-854	139	16	human	human	ADJ
admet-854	139	17	aks	ak	NOUN
admet-854	139	18	and	and	CCONJ
admet-854	139	19	bacterial	bacterial	ADJ
admet-854	139	20	aks	ak	NOUN
admet-854	139	21	with	with	ADP
admet-854	139	22	amantadine	amantadine	NOUN
admet-854	139	23	.	.	PUNCT
admet-854	140	1	the	the	DET
admet-854	140	2	ak4	ak4	NOUN
admet-854	140	3	is	be	AUX
admet-854	140	4	also	also	ADV
admet-854	140	5	named	name	VERB
admet-854	140	6	ak3	ak3	NOUN
admet-854	140	7	-	-	PUNCT
admet-854	140	8	like	like	ADJ
admet-854	140	9	and	and	CCONJ
admet-854	140	10	is	be	AUX
admet-854	140	11	a	a	DET
admet-854	140	12	gtp	gtp	NOUN
admet-854	140	13	:	:	PUNCT
admet-854	140	14	atp	atp	NOUN
admet-854	140	15	phosphotransferase	phosphotransferase	PROPN
admet-854	140	16	(	(	PUNCT
admet-854	140	17	ec	ec	PROPN
admet-854	140	18	2.7.4.10	2.7.4.10	NUM
admet-854	140	19	)	)	PUNCT
admet-854	141	1	[	[	X
admet-854	141	2	57–59	57–59	NUM
admet-854	141	3	]	]	PUNCT
admet-854	141	4	.	.	PUNCT
admet-854	142	1	the	the	DET
admet-854	142	2	mitochondrial	mitochondrial	ADJ
admet-854	142	3	human	human	ADJ
admet-854	142	4	ak4	ak4	NOUN
admet-854	142	5	(	(	PUNCT
admet-854	142	6	pdb	pdb	NOUN
admet-854	142	7	i	i	PROPN
admet-854	142	8	d	d	PROPN
admet-854	142	9	2bbw	2bbw	PROPN
admet-854	142	10	)	)	PUNCT
admet-854	142	11	was	be	AUX
admet-854	142	12	deposed	depose	VERB
admet-854	142	13	on	on	ADP
admet-854	142	14	pdb	pdb	PROPN
admet-854	142	15	in	in	ADP
admet-854	142	16	closed	closed	ADJ
admet-854	142	17	-	-	PUNCT
admet-854	142	18	conformation	conformation	NOUN
admet-854	142	19	co	co	NOUN
admet-854	142	20	-	-	VERB
admet-854	142	21	crystallized	crystallize	VERB
admet-854	142	22	with	with	ADP
admet-854	142	23	diguanosine	diguanosine	NOUN
admet-854	142	24	-	-	PUNCT
admet-854	142	25	pentaphosphate	pentaphosphate	NOUN
admet-854	142	26	(	(	PUNCT
admet-854	142	27	gp5	gp5	NOUN
admet-854	142	28	)	)	PUNCT
admet-854	142	29	.	.	PUNCT
admet-854	143	1	the	the	DET
admet-854	143	2	ak4	ak4	NOUN
admet-854	143	3	has	have	VERB
admet-854	143	4	some	some	DET
admet-854	143	5	characteristics	characteristic	NOUN
admet-854	143	6	that	that	PRON
admet-854	143	7	differentiate	differentiate	VERB
admet-854	143	8	it	it	PRON
admet-854	143	9	from	from	ADP
admet-854	143	10	other	other	ADJ
admet-854	143	11	ak	ak	PROPN
admet-854	143	12	isoforms	isoform	NOUN
admet-854	143	13	,	,	PUNCT
admet-854	143	14	the	the	DET
admet-854	143	15	most	most	ADV
admet-854	143	16	significant	significant	ADJ
admet-854	143	17	being	be	AUX
admet-854	143	18	its	its	PRON
admet-854	143	19	catalytic	catalytic	ADJ
admet-854	143	20	activity	activity	NOUN
admet-854	143	21	(	(	PUNCT
admet-854	143	22	a	a	DET
admet-854	143	23	ribonucleoside	ribonucleoside	NOUN
admet-854	143	24	5'-diphosphate	5'-diphosphate	NUM
admet-854	143	25	+	+	CCONJ
admet-854	143	26	atp	atp	NOUN
admet-854	143	27	=	=	PUNCT
admet-854	143	28	a	a	DET
admet-854	143	29	ribonucleoside	ribonucleoside	NOUN
admet-854	143	30	5'-triphosphate	5'-triphosphate	NOUN
admet-854	143	31	+	+	CCONJ
admet-854	143	32	adp	adp	PROPN
admet-854	143	33	)	)	PUNCT
admet-854	143	34	(	(	PUNCT
admet-854	143	35	https://www.uniprot.org/uniprot/p27144	https://www.uniprot.org/uniprot/p27144	PROPN
admet-854	143	36	)	)	PUNCT
admet-854	143	37	.	.	PUNCT
admet-854	144	1	because	because	SCONJ
admet-854	144	2	the	the	DET
admet-854	144	3	parameters	parameter	NOUN
admet-854	144	4	in	in	ADP
admet-854	144	5	the	the	DET
admet-854	144	6	input	input	NOUN
admet-854	144	7	file	file	NOUN
admet-854	144	8	do	do	AUX
admet-854	144	9	not	not	PART
admet-854	144	10	allow	allow	VERB
admet-854	144	11	substrate	substrate	NOUN
admet-854	144	12	redocking	redocking	NOUN
admet-854	144	13	,	,	PUNCT
admet-854	144	14	the	the	DET
admet-854	144	15	molecular	molecular	ADJ
admet-854	144	16	docking	docking	NOUN
admet-854	144	17	of	of	ADP
admet-854	144	18	amantadine	amantadine	NOUN
admet-854	144	19	with	with	ADP
admet-854	144	20	ak4	ak4	NOUN
admet-854	144	21	was	be	AUX
admet-854	144	22	not	not	PART
admet-854	144	23	made	make	VERB
admet-854	144	24	.	.	PUNCT
admet-854	145	1	(	(	PUNCT
admet-854	145	2	a	a	X
admet-854	145	3	)	)	PUNCT
admet-854	145	4	3hpq	3hpq	PROPN
admet-854	145	5	(	(	PUNCT
admet-854	145	6	e.coli	e.coli	NOUN
admet-854	145	7	ak	ak	PROPN
admet-854	145	8	)	)	PUNCT
admet-854	145	9	(	(	PUNCT
admet-854	145	10	b	b	X
admet-854	145	11	)	)	PUNCT
admet-854	145	12	1zip	1zip	NUM
admet-854	145	13	(	(	PUNCT
admet-854	145	14	b.strearothermophilus	b.strearothermophilus	PROPN
admet-854	145	15	ak	ak	PROPN
admet-854	145	16	)	)	PUNCT
admet-854	145	17	figure	figure	NOUN
admet-854	145	18	3	3	NUM
admet-854	145	19	.	.	PUNCT
admet-854	146	1	the	the	DET
admet-854	146	2	comparative	comparative	ADJ
admet-854	146	3	interactions	interaction	NOUN
admet-854	146	4	of	of	ADP
admet-854	146	5	the	the	DET
admet-854	146	6	bacterial	bacterial	ADJ
admet-854	146	7	aks	ak	NOUN
admet-854	146	8	with	with	ADP
admet-854	146	9	the	the	DET
admet-854	146	10	analog	analog	NOUN
admet-854	146	11	substrate	substrate	NOUN
admet-854	146	12	ap5a	ap5a	PROPN
admet-854	146	13	after	after	ADP
admet-854	146	14	redocking	redocke	VERB
admet-854	146	15	.	.	PUNCT
admet-854	147	1	the	the	DET
admet-854	147	2	redocked	redocke	VERB
admet-854	147	3	conformations	conformation	NOUN
admet-854	147	4	are	be	AUX
admet-854	147	5	shown	show	VERB
admet-854	147	6	in	in	ADP
admet-854	147	7	yellow	yellow	ADJ
admet-854	147	8	.	.	PUNCT
admet-854	148	1	(	(	PUNCT
admet-854	148	2	a	a	X
admet-854	148	3	)	)	PUNCT
admet-854	148	4	e.coli	e.coli	NOUN
admet-854	148	5	ak	ak	PROPN
admet-854	148	6	(	(	PUNCT
admet-854	148	7	pdb	pdb	PROPN
admet-854	148	8	i	i	PROPN
admet-854	148	9	d	d	PROPN
admet-854	148	10	3hpq	3hpq	PROPN
admet-854	148	11	)	)	PUNCT
admet-854	148	12	;	;	PUNCT
admet-854	148	13	(	(	PUNCT
admet-854	148	14	b	b	X
admet-854	148	15	)	)	PUNCT
admet-854	148	16	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	148	17	ak	ak	PROPN
admet-854	148	18	(	(	PUNCT
admet-854	148	19	pdb	pdb	PROPN
admet-854	148	20	i	i	PROPN
admet-854	148	21	d	d	PROPN
admet-854	148	22	1zip	1zip	NUM
admet-854	148	23	)	)	PUNCT
admet-854	148	24	.	.	PUNCT
admet-854	149	1	molecular	molecular	ADJ
admet-854	149	2	docking	docking	NOUN
admet-854	149	3	of	of	ADP
admet-854	149	4	ionized	ionize	VERB
admet-854	149	5	amantadine	amantadine	NOUN
admet-854	149	6	with	with	ADP
admet-854	149	7	ak1	ak1	NOUN
admet-854	149	8	the	the	DET
admet-854	149	9	three	three	NUM
admet-854	149	10	x	x	NOUN
admet-854	149	11	-	-	NOUN
admet-854	149	12	ray	ray	ADJ
admet-854	149	13	3d	3d	NOUN
admet-854	149	14	structures	structure	NOUN
admet-854	149	15	of	of	ADP
admet-854	149	16	the	the	DET
admet-854	149	17	ak1	ak1	NOUN
admet-854	149	18	were	be	AUX
admet-854	149	19	analyzed	analyze	VERB
admet-854	149	20	for	for	ADP
admet-854	149	21	their	their	PRON
admet-854	149	22	interaction	interaction	NOUN
admet-854	149	23	with	with	ADP
admet-854	149	24	ionized	ionized	ADJ
admet-854	149	25	amantadine	amantadine	NOUN
admet-854	149	26	(	(	PUNCT
admet-854	149	27	with	with	ADP
admet-854	149	28	–	–	PUNCT
admet-854	149	29	nh3	nh3	NOUN
admet-854	149	30	+	+	NUM
admet-854	149	31	group	group	NOUN
admet-854	149	32	)	)	PUNCT
admet-854	149	33	.	.	PUNCT
admet-854	150	1	the	the	DET
admet-854	150	2	human	human	PROPN
admet-854	150	3	ak1	ak1	PROPN
admet-854	150	4	co	co	VERB
admet-854	150	5	-	-	VERB
admet-854	150	6	crystallized	crystallized	ADJ
admet-854	150	7	with	with	ADP
admet-854	150	8	ap5a	ap5a	PROPN
admet-854	150	9	(	(	PUNCT
admet-854	150	10	pdb	pdb	PROPN
admet-854	150	11	i	i	PROPN
admet-854	150	12	d	d	PROPN
admet-854	150	13	1z83	1z83	X
admet-854	150	14	)	)	PUNCT
admet-854	150	15	mostly	mostly	ADV
admet-854	150	16	interacts	interact	VERB
admet-854	150	17	with	with	ADP
admet-854	150	18	ionized	ionized	ADJ
admet-854	150	19	amantadine	amantadine	NOUN
admet-854	150	20	with	with	ADP
admet-854	150	21	the	the	DET
admet-854	150	22	residues	residue	NOUN
admet-854	150	23	involved	involve	VERB
admet-854	150	24	in	in	ADP
admet-854	150	25	amp	amp	NOUN
admet-854	150	26	binding	binding	NOUN
admet-854	150	27	.	.	PUNCT
admet-854	151	1	thus	thus	ADV
admet-854	151	2	,	,	PUNCT
admet-854	151	3	the	the	DET
admet-854	151	4	enzyme	enzyme	NOUN
admet-854	151	5	forms	form	VERB
admet-854	151	6	van	van	PROPN
admet-854	151	7	der	der	ADJ
admet-854	151	8	waals	waal	NOUN
admet-854	151	9	forces	force	NOUN
admet-854	151	10	with	with	ADP
admet-854	151	11	thr39	thr39	PROPN
admet-854	151	12	,	,	PUNCT
admet-854	151	13	tyr95	tyr95	NOUN
admet-854	151	14	,	,	PUNCT
admet-854	151	15	and	and	CCONJ
admet-854	151	16	pro96	pro96	VERB
admet-854	151	17	;	;	PUNCT
admet-854	151	18	conventional	conventional	ADJ
admet-854	151	19	hydrogen	hydrogen	NOUN
admet-854	151	20	bonds	bond	NOUN
admet-854	151	21	with	with	ADP
admet-854	151	22	gly94	gly94	NOUN
admet-854	151	23	and	and	CCONJ
admet-854	151	24	gln101	gln101	PROPN
admet-854	151	25	;	;	PUNCT
admet-854	151	26	and	and	CCONJ
admet-854	151	27	an	an	DET
admet-854	151	28	unfavorable	unfavorable	ADJ
admet-854	151	29	positive	positive	ADJ
admet-854	151	30	-	-	PUNCT
admet-854	151	31	positive	positive	ADJ
admet-854	151	32	interaction	interaction	NOUN
admet-854	151	33	with	with	ADP
admet-854	151	34	arg97	arg97	NOUN
admet-854	151	35	.	.	PUNCT
admet-854	152	1	in	in	ADP
admet-854	152	2	total	total	NOUN
admet-854	152	3	,	,	PUNCT
admet-854	152	4	there	there	PRON
admet-854	152	5	are	be	VERB
admet-854	152	6	five	five	NUM
admet-854	152	7	residues	residue	NOUN
admet-854	152	8	from	from	ADP
admet-854	152	9	the	the	DET
admet-854	152	10	nmp	nmp	NOUN
admet-854	152	11	binding	bind	VERB
admet-854	152	12	region	region	NOUN
admet-854	152	13	that	that	PRON
admet-854	152	14	interact	interact	VERB
admet-854	152	15	with	with	ADP
admet-854	152	16	ionized	ionized	ADJ
admet-854	152	17	amantadine	amantadine	NOUN
admet-854	152	18	–	–	PUNCT
admet-854	152	19	thr39	thr39	ADJ
admet-854	152	20	,	,	PUNCT
admet-854	152	21	gly40	gly40	NOUN
admet-854	152	22	,	,	PUNCT
admet-854	152	23	leu43	leu43	PROPN
admet-854	152	24	,	,	PUNCT
admet-854	152	25	leu66	leu66	PROPN
admet-854	152	26	,	,	PUNCT
admet-854	152	27	and	and	CCONJ
admet-854	152	28	val67	val67	PROPN
admet-854	152	29	(	(	PUNCT
admet-854	152	30	figure	figure	NOUN
admet-854	152	31	4	4	NUM
admet-854	152	32	)	)	PUNCT
admet-854	152	33	.	.	PUNCT
admet-854	153	1	a	a	DET
admet-854	153	2	comparison	comparison	NOUN
admet-854	153	3	of	of	ADP
admet-854	153	4	the	the	DET
admet-854	153	5	ak1	ak1	NOUN
admet-854	153	6	(	(	PUNCT
admet-854	153	7	pdb	pdb	PROPN
admet-854	153	8	i	i	PROPN
admet-854	153	9	d	d	PROPN
admet-854	153	10	1z83	1z83	X
admet-854	153	11	)	)	PUNCT
admet-854	153	12	interactions	interaction	NOUN
admet-854	153	13	with	with	ADP
admet-854	153	14	the	the	DET
admet-854	153	15	two	two	NUM
admet-854	153	16	forms	form	NOUN
admet-854	153	17	of	of	ADP
admet-854	153	18	amantadine	amantadine	NOUN
admet-854	153	19	,	,	PUNCT
admet-854	153	20	reveals	reveal	VERB
admet-854	153	21	that	that	SCONJ
admet-854	153	22	the	the	DET
admet-854	153	23	group	group	NOUN
admet-854	153	24	–	–	PUNCT
admet-854	153	25	nh3	nh3	PROPN
admet-854	153	26	+	+	SYM
admet-854	153	27	of	of	ADP
admet-854	153	28	the	the	DET
admet-854	153	29	ionized	ionized	ADJ
admet-854	153	30	amantadine	amantadine	NOUN
admet-854	153	31	is	be	AUX
admet-854	153	32	involved	involve	VERB
admet-854	153	33	in	in	ADP
admet-854	153	34	three	three	NUM
admet-854	153	35	conventional	conventional	ADJ
admet-854	153	36	hydrogen	hydrogen	NOUN
admet-854	153	37	bonds	bond	NOUN
admet-854	153	38	like	like	ADP
admet-854	153	39	the	the	DET
admet-854	153	40	–	–	PUNCT
admet-854	153	41	nh2	nh2	NOUN
admet-854	153	42	group	group	NOUN
admet-854	153	43	of	of	ADP
admet-854	153	44	the	the	DET
admet-854	153	45	unionized	unionized	ADJ
admet-854	153	46	form	form	NOUN
admet-854	153	47	.	.	PUNCT
admet-854	154	1	the	the	DET
admet-854	154	2	difference	difference	NOUN
admet-854	154	3	lies	lie	VERB
admet-854	154	4	in	in	ADP
admet-854	154	5	the	the	DET
admet-854	154	6	residues	residue	NOUN
admet-854	154	7	involved	involve	VERB
admet-854	154	8	in	in	ADP
admet-854	154	9	these	these	DET
admet-854	154	10	interactions	interaction	NOUN
admet-854	154	11	–	–	PUNCT
admet-854	154	12	val67	val67	ADJ
admet-854	154	13	interacts	interact	VERB
admet-854	154	14	with	with	ADP
admet-854	154	15	–	–	PUNCT
admet-854	154	16	nh2	nh2	NOUN
admet-854	154	17	of	of	ADP
admet-854	154	18	unionized	unionized	ADJ
admet-854	154	19	amantadine	amantadine	NOUN
admet-854	154	20	,	,	PUNCT
admet-854	154	21	respectively	respectively	ADV
admet-854	154	22	gln94	gln94	NOUN
admet-854	154	23	and	and	CCONJ
admet-854	154	24	gln101	gln101	PROPN
admet-854	154	25	with	with	ADP
admet-854	154	26	–	–	PUNCT
admet-854	154	27	nh3	nh3	NOUN
admet-854	154	28	+	+	X
admet-854	154	29	of	of	ADP
admet-854	154	30	ionized	ionized	ADJ
admet-854	154	31	amantadine	amantadine	NOUN
admet-854	154	32	.	.	PUNCT
admet-854	154	33	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	155	1	https://www.uniprot.org/uniprot/p27144	https://www.uniprot.org/uniprot/p27144	PROPN
admet-854	155	2	mihaela	mihaela	PROPN
admet-854	155	3	ileana	ileana	PROPN
admet-854	155	4	ionescu	ionescu	PROPN
admet-854	155	5	admet	admet	PROPN
admet-854	155	6	&	&	CCONJ
admet-854	155	7	dmpk	dmpk	PROPN
admet-854	155	8	8(2	8(2	NUM
admet-854	155	9	)	)	PUNCT
admet-854	155	10	(	(	PUNCT
admet-854	155	11	2020	2020	NUM
admet-854	155	12	)	)	PUNCT
admet-854	155	13	149	149	NUM
admet-854	155	14	-	-	SYM
admet-854	155	15	175	175	NUM
admet-854	155	16	156	156	NUM
admet-854	155	17	gln101	gln101	NOUN
admet-854	155	18	:	:	PUNCT
admet-854	155	19	oe1	oe1	ADJ
admet-854	155	20	-	-	PUNCT
admet-854	155	21	h27	h27	NOUN
admet-854	155	22	2.26	2.26	NUM
admet-854	155	23	å	å	PROPN
admet-854	155	24	gln101	gln101	PROPN
admet-854	155	25	:	:	PUNCT
admet-854	155	26	oe1	oe1	NOUN
admet-854	155	27	-	-	PUNCT
admet-854	155	28	h5	h5	NOUN
admet-854	155	29	2.09	2.09	NUM
admet-854	155	30	å	å	PROPN
admet-854	155	31	gly94	gly94	NOUN
admet-854	155	32	:o	:o	PROPN
admet-854	155	33	-	-	PUNCT
admet-854	155	34	h27	h27	PROPN
admet-854	155	35	1.92	1.92	NUM
admet-854	155	36	å	å	PROPN
admet-854	155	37	leu43	leu43	PROPN
admet-854	155	38	4.93	4.93	NUM
admet-854	155	39	å	å	PROPN
admet-854	155	40	leu66	leu66	PROPN
admet-854	155	41	4.48	4.48	NUM
admet-854	155	42	å	å	PROPN
admet-854	155	43	val67	val67	PROPN
admet-854	155	44	4.68	4.68	NUM
admet-854	155	45	å	å	PROPN
admet-854	155	46	val72	val72	NOUN
admet-854	155	47	5.05	5.05	NUM
admet-854	155	48	å	å	PROPN
admet-854	155	49	arg97	arg97	PROPN
admet-854	155	50	5.46	5.46	NUM
admet-854	155	51	å	å	PROPN
admet-854	155	52	leu43	leu43	PROPN
admet-854	155	53	-	-	PUNCT
admet-854	155	54	c9	c9	NOUN
admet-854	155	55	4.34	4.34	NUM
admet-854	155	56	å	å	DET
admet-854	155	57	val67	val67	PROPN
admet-854	155	58	-	-	PUNCT
admet-854	155	59	c9	c9	NOUN
admet-854	155	60	3.78	3.78	NUM
admet-854	155	61	å	å	PROPN
admet-854	155	62	val72	val72	NOUN
admet-854	155	63	-	-	PUNCT
admet-854	155	64	c9	c9	NOUN
admet-854	155	65	3.74	3.74	NUM
admet-854	155	66	å	å	PROPN
admet-854	155	67	arg97	arg97	NOUN
admet-854	155	68	:	:	PUNCT
admet-854	155	69	nh2	nh2	NOUN
admet-854	155	70	-	-	PUNCT
admet-854	155	71	n1	n1	NOUN
admet-854	155	72	5.46å	5.46å	NUM
admet-854	155	73	(	(	PUNCT
admet-854	155	74	a	a	NOUN
admet-854	155	75	)	)	PUNCT
admet-854	155	76	(	(	PUNCT
admet-854	155	77	b	b	X
admet-854	155	78	)	)	PUNCT
admet-854	155	79	(	(	PUNCT
admet-854	155	80	c	c	X
admet-854	155	81	)	)	PUNCT
admet-854	155	82	figure	figure	NOUN
admet-854	155	83	4	4	NUM
admet-854	155	84	.	.	PUNCT
admet-854	155	85	interactions	interaction	NOUN
admet-854	155	86	of	of	ADP
admet-854	155	87	ionized	ionized	ADJ
admet-854	155	88	amantadine	amantadine	NOUN
admet-854	155	89	with	with	ADP
admet-854	155	90	human	human	PROPN
admet-854	155	91	ak1	ak1	PROPN
admet-854	155	92	,	,	PUNCT
admet-854	155	93	pdb	pdb	PROPN
admet-854	155	94	i	i	PROPN
admet-854	155	95	d	d	PROPN
admet-854	155	96	1z83	1z83	X
admet-854	155	97	.	.	PUNCT
admet-854	156	1	(	(	PUNCT
admet-854	156	2	a	a	X
admet-854	156	3	)	)	PUNCT
admet-854	156	4	3d	3d	NUM
admet-854	156	5	display	display	NOUN
admet-854	156	6	of	of	ADP
admet-854	156	7	ionized	ionize	VERB
admet-854	156	8	amantadine	amantadine	NOUN
admet-854	156	9	interaction	interaction	NOUN
admet-854	156	10	as	as	ADP
admet-854	156	11	ligand	ligand	NOUN
admet-854	156	12	with	with	ADP
admet-854	156	13	the	the	DET
admet-854	156	14	1z83	1z83	NUM
admet-854	156	15	residues	residue	NOUN
admet-854	156	16	;	;	PUNCT
admet-854	156	17	(	(	PUNCT
admet-854	156	18	b	b	X
admet-854	156	19	)	)	PUNCT
admet-854	156	20	code	code	NOUN
admet-854	156	21	color	color	NOUN
admet-854	156	22	for	for	ADP
admet-854	156	23	interactions	interaction	NOUN
admet-854	156	24	:	:	PUNCT
admet-854	156	25	in	in	ADP
admet-854	156	26	green	green	NOUN
admet-854	156	27	are	be	AUX
admet-854	156	28	shown	show	VERB
admet-854	156	29	conventional	conventional	ADJ
admet-854	156	30	hydrogen	hydrogen	NOUN
admet-854	156	31	bonds	bond	NOUN
admet-854	156	32	,	,	PUNCT
admet-854	156	33	light	light	ADJ
admet-854	156	34	green	green	ADJ
admet-854	156	35	–	–	PUNCT
admet-854	156	36	van	van	PROPN
admet-854	156	37	der	der	NOUN
admet-854	156	38	waals	waal	NOUN
admet-854	156	39	forces	force	NOUN
admet-854	156	40	,	,	PUNCT
admet-854	156	41	mauve	mauve	NOUN
admet-854	156	42	–	–	PUNCT
admet-854	156	43	alkyl	alkyl	ADJ
admet-854	156	44	hydrophobic	hydrophobic	NOUN
admet-854	156	45	interactions	interaction	NOUN
admet-854	156	46	,	,	PUNCT
admet-854	156	47	red	red	ADJ
admet-854	156	48	–	–	PUNCT
admet-854	156	49	unfavorable	unfavorable	ADJ
admet-854	156	50	positive	positive	ADJ
admet-854	156	51	-	-	PUNCT
admet-854	156	52	positive	positive	ADJ
admet-854	156	53	interactions	interaction	NOUN
admet-854	156	54	;	;	PUNCT
admet-854	156	55	(	(	PUNCT
admet-854	156	56	c	c	X
admet-854	156	57	)	)	PUNCT
admet-854	156	58	the	the	DET
admet-854	156	59	distances	distance	NOUN
admet-854	156	60	(	(	PUNCT
admet-854	156	61	å	å	NOUN
admet-854	156	62	)	)	PUNCT
admet-854	156	63	of	of	ADP
admet-854	156	64	the	the	DET
admet-854	156	65	1z83	1z83	NUM
admet-854	156	66	ionized	ionize	VERB
admet-854	156	67	amantadine	amantadine	NOUN
admet-854	156	68	interactions	interaction	NOUN
admet-854	156	69	.	.	PUNCT
admet-854	157	1	the	the	DET
admet-854	157	2	human	human	PROPN
admet-854	157	3	ak1	ak1	PROPN
admet-854	157	4	co	co	VERB
admet-854	157	5	-	-	VERB
admet-854	157	6	crystallized	crystallized	ADJ
admet-854	157	7	with	with	ADP
admet-854	157	8	b4p	b4p	PROPN
admet-854	157	9	(	(	PUNCT
admet-854	157	10	pdb	pdb	PROPN
admet-854	157	11	i	i	NOUN
admet-854	157	12	d	d	PROPN
admet-854	157	13	2c95	2c95	ADV
admet-854	157	14	)	)	PUNCT
admet-854	157	15	forms	form	VERB
admet-854	157	16	an	an	DET
admet-854	157	17	electrostatic	electrostatic	ADJ
admet-854	157	18	interaction	interaction	NOUN
admet-854	157	19	between	between	ADP
admet-854	157	20	glu62	glu62	PROPN
admet-854	157	21	,	,	PUNCT
admet-854	157	22	a	a	DET
admet-854	157	23	residue	residue	NOUN
admet-854	157	24	belonging	belong	VERB
admet-854	157	25	to	to	ADP
admet-854	157	26	nmp	nmp	X
admet-854	157	27	binding	bind	VERB
admet-854	157	28	region	region	NOUN
admet-854	157	29	,	,	PUNCT
admet-854	157	30	and	and	CCONJ
admet-854	157	31	–	–	PUNCT
admet-854	157	32	nh3	nh3	NOUN
admet-854	157	33	+	+	NUM
admet-854	157	34	group	group	NOUN
admet-854	157	35	of	of	ADP
admet-854	157	36	ionized	ionize	VERB
admet-854	157	37	amantadine	amantadine	NOUN
admet-854	157	38	.	.	PUNCT
admet-854	158	1	the	the	DET
admet-854	158	2	same	same	ADJ
admet-854	158	3	residue	residue	NOUN
admet-854	158	4	,	,	PUNCT
admet-854	158	5	glu62	glu62	ADJ
admet-854	158	6	,	,	PUNCT
admet-854	158	7	interacts	interact	VERB
admet-854	158	8	with	with	ADP
admet-854	158	9	the	the	DET
admet-854	158	10	–	–	PUNCT
admet-854	158	11	nh2	nh2	NOUN
admet-854	158	12	group	group	NOUN
admet-854	158	13	of	of	ADP
admet-854	158	14	the	the	DET
admet-854	158	15	unionized	unionize	VERB
admet-854	158	16	amantadine	amantadine	NOUN
admet-854	158	17	by	by	ADP
admet-854	158	18	two	two	NUM
admet-854	158	19	conventional	conventional	ADJ
admet-854	158	20	hydrogen	hydrogen	NOUN
admet-854	158	21	bonds	bond	NOUN
admet-854	158	22	.	.	PUNCT
admet-854	159	1	in	in	ADP
admet-854	159	2	contrast	contrast	NOUN
admet-854	159	3	with	with	ADP
admet-854	159	4	human	human	ADJ
admet-854	159	5	ak1	ak1	PROPN
admet-854	159	6	(	(	PUNCT
admet-854	159	7	pdb	pdb	PROPN
admet-854	159	8	i	i	PROPN
admet-854	159	9	d	d	PROPN
admet-854	159	10	1z83	1z83	X
admet-854	159	11	)	)	PUNCT
admet-854	159	12	,	,	PUNCT
admet-854	159	13	the	the	DET
admet-854	159	14	human	human	PROPN
admet-854	159	15	ak1	ak1	PROPN
admet-854	159	16	(	(	PUNCT
admet-854	159	17	pdb	pdb	PROPN
admet-854	159	18	i	i	NOUN
admet-854	159	19	d	d	PROPN
admet-854	159	20	2c95	2c95	ADV
admet-854	159	21	)	)	PUNCT
admet-854	159	22	interacts	interact	VERB
admet-854	159	23	with	with	ADP
admet-854	159	24	ionized	ionized	ADJ
admet-854	159	25	amantadine	amantadine	NOUN
admet-854	159	26	with	with	ADP
admet-854	159	27	residues	residue	NOUN
admet-854	159	28	belonging	belong	VERB
admet-854	159	29	to	to	ADP
admet-854	159	30	nmp	nmp	X
admet-854	159	31	binding	bind	VERB
admet-854	159	32	region	region	NOUN
admet-854	159	33	(	(	PUNCT
admet-854	159	34	arg44	arg44	PROPN
admet-854	159	35	,	,	PUNCT
admet-854	159	36	val47	val47	ADJ
admet-854	159	37	,	,	PUNCT
admet-854	159	38	ser58	ser58	NOUN
admet-854	159	39	,	,	PUNCT
admet-854	159	40	met61	met61	NOUN
admet-854	159	41	,	,	PUNCT
admet-854	159	42	and	and	CCONJ
admet-854	159	43	glu62	glu62	ADJ
admet-854	159	44	)	)	PUNCT
admet-854	159	45	and	and	CCONJ
admet-854	159	46	lid	lid	NOUN
admet-854	159	47	domain	domain	NOUN
admet-854	159	48	(	(	PUNCT
admet-854	159	49	gly137	gly137	PROPN
admet-854	159	50	,	,	PUNCT
admet-854	159	51	arg138	arg138	PROPN
admet-854	159	52	,	,	PUNCT
admet-854	159	53	val139	val139	PROPN
admet-854	159	54	,	,	PUNCT
admet-854	159	55	and	and	CCONJ
admet-854	159	56	asp140	asp140	PROPN
admet-854	159	57	)	)	PUNCT
admet-854	159	58	.	.	PUNCT
admet-854	160	1	more	more	ADJ
admet-854	160	2	,	,	PUNCT
admet-854	160	3	ak1	ak1	PROPN
admet-854	160	4	(	(	PUNCT
admet-854	160	5	pdb	pdb	PROPN
admet-854	160	6	i	i	NOUN
admet-854	160	7	d	d	PROPN
admet-854	160	8	2c95	2c95	ADV
admet-854	160	9	)	)	PUNCT
admet-854	160	10	interacts	interact	VERB
admet-854	160	11	with	with	ADP
admet-854	160	12	only	only	ADV
admet-854	160	13	two	two	NUM
admet-854	160	14	amp	amp	NOUN
admet-854	160	15	binding	bind	VERB
admet-854	160	16	residues	residue	NOUN
admet-854	160	17	–	–	PUNCT
admet-854	160	18	arg44	arg44	NOUN
admet-854	160	19	and	and	CCONJ
admet-854	160	20	arg138	arg138	PROPN
admet-854	160	21	(	(	PUNCT
admet-854	160	22	figure	figure	NOUN
admet-854	160	23	5	5	NUM
admet-854	160	24	)	)	PUNCT
admet-854	160	25	.	.	PUNCT
admet-854	161	1	glu62	glu62	ADJ
admet-854	161	2	:	:	PUNCT
admet-854	161	3	oe2	oe2	NOUN
admet-854	161	4	-	-	NOUN
admet-854	161	5	h27	h27	NOUN
admet-854	161	6	1.75	1.75	NUM
admet-854	161	7	å	å	PROPN
admet-854	161	8	arg44	arg44	NOUN
admet-854	161	9	4.10	4.10	NUM
admet-854	161	10	å	å	PROPN
admet-854	161	11	arg44	arg44	NOUN
admet-854	161	12	4.63	4.63	NUM
admet-854	161	13	å	å	NOUN
admet-854	161	14	val47	val47	ADJ
admet-854	161	15	5.33	5.33	NUM
admet-854	161	16	å	å	NOUN
admet-854	161	17	met61	met61	VERB
admet-854	161	18	4.12	4.12	NUM
admet-854	161	19	å	å	PRON
admet-854	161	20	arg138	arg138	PROPN
admet-854	161	21	-	-	PUNCT
admet-854	161	22	c9	c9	PROPN
admet-854	161	23	4.45	4.45	NUM
admet-854	161	24	å	å	PROPN
admet-854	161	25	val139	val139	PROPN
admet-854	161	26	-	-	PUNCT
admet-854	161	27	c9	c9	NOUN
admet-854	161	28	4.55	4.55	NUM
admet-854	161	29	å	å	PROPN
admet-854	161	30	(	(	PUNCT
admet-854	161	31	a	a	NOUN
admet-854	161	32	)	)	PUNCT
admet-854	161	33	(	(	PUNCT
admet-854	161	34	b	b	X
admet-854	161	35	)	)	PUNCT
admet-854	161	36	(	(	PUNCT
admet-854	161	37	c	c	X
admet-854	161	38	)	)	PUNCT
admet-854	161	39	figure	figure	NOUN
admet-854	161	40	5	5	NUM
admet-854	161	41	.	.	PUNCT
admet-854	161	42	interactions	interaction	NOUN
admet-854	161	43	of	of	ADP
admet-854	161	44	ionized	ionized	ADJ
admet-854	161	45	amantadine	amantadine	NOUN
admet-854	161	46	with	with	ADP
admet-854	161	47	human	human	PROPN
admet-854	161	48	ak1	ak1	PROPN
admet-854	161	49	,	,	PUNCT
admet-854	161	50	pdb	pdb	PROPN
admet-854	162	1	i	i	NOUN
admet-854	162	2	d	d	PROPN
admet-854	162	3	2c95	2c95	ADV
admet-854	162	4	.	.	PUNCT
admet-854	163	1	(	(	PUNCT
admet-854	163	2	a	a	X
admet-854	163	3	)	)	PUNCT
admet-854	163	4	3d	3d	NUM
admet-854	163	5	display	display	NOUN
admet-854	163	6	of	of	ADP
admet-854	163	7	ionized	ionize	VERB
admet-854	163	8	amantadine	amantadine	NOUN
admet-854	163	9	interaction	interaction	NOUN
admet-854	163	10	as	as	ADP
admet-854	163	11	ligand	ligand	NOUN
admet-854	163	12	with	with	ADP
admet-854	163	13	the	the	DET
admet-854	163	14	2c95	2c95	NUM
admet-854	163	15	residues	residue	NOUN
admet-854	163	16	;	;	PUNCT
admet-854	163	17	(	(	PUNCT
admet-854	163	18	b	b	X
admet-854	163	19	)	)	PUNCT
admet-854	163	20	code	code	NOUN
admet-854	163	21	color	color	NOUN
admet-854	163	22	for	for	ADP
admet-854	163	23	interactions	interaction	NOUN
admet-854	163	24	:	:	PUNCT
admet-854	163	25	in	in	ADP
admet-854	163	26	orange	orange	NOUN
admet-854	163	27	are	be	AUX
admet-854	163	28	shown	show	VERB
admet-854	163	29	the	the	DET
admet-854	163	30	salt	salt	NOUN
admet-854	163	31	bridge	bridge	NOUN
admet-854	163	32	,	,	PUNCT
admet-854	163	33	light	light	ADJ
admet-854	163	34	green	green	ADJ
admet-854	163	35	–	–	PUNCT
admet-854	163	36	van	van	PROPN
admet-854	163	37	der	der	NOUN
admet-854	163	38	waals	waal	NOUN
admet-854	163	39	forces	force	NOUN
admet-854	163	40	,	,	PUNCT
admet-854	163	41	mauve	mauve	NOUN
admet-854	163	42	–	–	PUNCT
admet-854	163	43	alkyl	alkyl	ADJ
admet-854	163	44	hydrophobic	hydrophobic	NOUN
admet-854	163	45	interactions	interaction	NOUN
admet-854	163	46	;	;	PUNCT
admet-854	163	47	(	(	PUNCT
admet-854	163	48	c	c	X
admet-854	163	49	)	)	PUNCT
admet-854	163	50	the	the	DET
admet-854	163	51	distances	distance	NOUN
admet-854	163	52	(	(	PUNCT
admet-854	163	53	å	å	NOUN
admet-854	163	54	)	)	PUNCT
admet-854	163	55	of	of	ADP
admet-854	163	56	the	the	DET
admet-854	163	57	2c95	2c95	ADV
admet-854	163	58	ionized	ionized	ADJ
admet-854	163	59	amantadine	amantadine	NOUN
admet-854	163	60	interactions	interaction	NOUN
admet-854	163	61	.	.	PUNCT
admet-854	164	1	the	the	DET
admet-854	164	2	zebrafish	zebrafish	PROPN
admet-854	164	3	ak1	ak1	NOUN
admet-854	164	4	co	co	VERB
admet-854	164	5	-	-	VERB
admet-854	164	6	crystallized	crystallized	ADJ
admet-854	164	7	with	with	ADP
admet-854	164	8	ap5a	ap5a	PROPN
admet-854	164	9	(	(	PUNCT
admet-854	164	10	pdb	pdb	PROPN
admet-854	164	11	i	i	PROPN
admet-854	164	12	d	d	PROPN
admet-854	164	13	5xz2	5xz2	NUM
admet-854	164	14	)	)	PUNCT
admet-854	164	15	shows	show	VERB
admet-854	164	16	much	much	ADV
admet-854	164	17	more	more	ADJ
admet-854	164	18	differences	difference	NOUN
admet-854	164	19	regarding	regard	VERB
admet-854	164	20	the	the	DET
admet-854	164	21	interactions	interaction	NOUN
admet-854	164	22	with	with	ADP
admet-854	164	23	ionized	ionized	ADJ
admet-854	164	24	amantadine	amantadine	NOUN
admet-854	164	25	,	,	PUNCT
admet-854	164	26	no	no	DET
admet-854	164	27	residue	residue	NOUN
admet-854	164	28	which	which	PRON
admet-854	164	29	interacts	interact	VERB
admet-854	164	30	with	with	ADP
admet-854	164	31	unionized	unionize	VERB
admet-854	164	32	amantadine	amantadine	NOUN
admet-854	164	33	interact	interact	NOUN
admet-854	164	34	with	with	ADP
admet-854	164	35	ionized	ionized	ADJ
admet-854	164	36	amantadine	amantadine	NOUN
admet-854	164	37	.	.	PUNCT
admet-854	165	1	in	in	ADP
admet-854	165	2	contrast	contrast	NOUN
admet-854	165	3	with	with	ADP
admet-854	165	4	unionized	unionized	ADJ
admet-854	165	5	amantadine	amantadine	NOUN
admet-854	165	6	,	,	PUNCT
admet-854	165	7	the	the	DET
admet-854	165	8	–	–	PUNCT
admet-854	165	9	nh3	nh3	NOUN
admet-854	165	10	+	+	NOUN
admet-854	165	11	group	group	NOUN
admet-854	165	12	of	of	ADP
admet-854	165	13	the	the	DET
admet-854	165	14	ionized	ionize	VERB
admet-854	165	15	amantadine	amantadine	NOUN
admet-854	165	16	interacts	interact	VERB
admet-854	165	17	with	with	ADP
admet-854	165	18	the	the	DET
admet-854	165	19	residues	residue	NOUN
admet-854	165	20	involved	involve	VERB
admet-854	165	21	in	in	ADP
admet-854	165	22	catalysis	catalysis	NOUN
admet-854	165	23	–	–	PUNCT
admet-854	165	24	one	one	NUM
admet-854	165	25	residue	residue	NOUN
admet-854	165	26	from	from	ADP
admet-854	165	27	the	the	DET
admet-854	165	28	nmp	nmp	NOUN
admet-854	165	29	binding	bind	VERB
admet-854	165	30	region	region	NOUN
admet-854	165	31	,	,	PUNCT
admet-854	165	32	met61	met61	NOUN
admet-854	165	33	,	,	PUNCT
admet-854	165	34	forms	form	VERB
admet-854	165	35	a	a	DET
admet-854	165	36	conventional	conventional	ADJ
admet-854	165	37	hydrogen	hydrogen	NOUN
admet-854	165	38	bond	bond	NOUN
admet-854	165	39	and	and	CCONJ
admet-854	165	40	asp140	asp140	ADJ
admet-854	165	41	from	from	ADP
admet-854	165	42	the	the	DET
admet-854	165	43	lid	lid	NOUN
admet-854	165	44	domain	domain	NOUN
admet-854	165	45	forms	form	VERB
admet-854	165	46	two	two	NUM
admet-854	165	47	electrostatic	electrostatic	ADJ
admet-854	165	48	interactions	interaction	NOUN
admet-854	165	49	.	.	PUNCT
admet-854	166	1	similar	similar	ADJ
admet-854	166	2	to	to	ADP
admet-854	166	3	human	human	PROPN
admet-854	166	4	ak1	ak1	PROPN
admet-854	166	5	(	(	PUNCT
admet-854	166	6	pdb	pdb	PROPN
admet-854	166	7	i	i	NOUN
admet-854	166	8	d	d	PROPN
admet-854	166	9	2c95	2c95	NUM
admet-854	166	10	)	)	PUNCT
admet-854	166	11	,	,	PUNCT
admet-854	166	12	the	the	DET
admet-854	166	13	zebrafish	zebrafish	PROPN
admet-854	166	14	ak1	ak1	NOUN
admet-854	166	15	interacts	interact	VERB
admet-854	166	16	with	with	ADP
admet-854	166	17	ionized	ionize	VERB
admet-854	166	18	amantadine	amantadine	NOUN
admet-854	166	19	by	by	ADP
admet-854	166	20	residues	residue	NOUN
admet-854	166	21	from	from	ADP
admet-854	166	22	the	the	DET
admet-854	166	23	nmp	nmp	NOUN
admet-854	166	24	binding	bind	VERB
admet-854	166	25	region	region	NOUN
admet-854	166	26	(	(	PUNCT
admet-854	166	27	leu43	leu43	PROPN
admet-854	166	28	,	,	PUNCT
admet-854	166	29	met61	met61	NOUN
admet-854	166	30	,	,	PUNCT
admet-854	166	31	gly64	gly64	NOUN
admet-854	166	32	,	,	PUNCT
admet-854	166	33	glu65	glu65	NOUN
admet-854	166	34	,	,	PUNCT
admet-854	166	35	leu66	leu66	PROPN
admet-854	166	36	,	,	PUNCT
admet-854	166	37	and	and	CCONJ
admet-854	166	38	val67	val67	ADJ
admet-854	166	39	)	)	PUNCT
admet-854	166	40	and	and	CCONJ
admet-854	166	41	with	with	ADP
admet-854	166	42	residues	residue	NOUN
admet-854	166	43	from	from	ADP
admet-854	166	44	the	the	DET
admet-854	166	45	lid	lid	NOUN
admet-854	166	46	admet	admet	NOUN
admet-854	166	47	&	&	CCONJ
admet-854	166	48	dmpk	dmpk	PROPN
admet-854	166	49	8(2	8(2	NUM
admet-854	166	50	)	)	PUNCT
admet-854	166	51	(	(	PUNCT
admet-854	166	52	2020	2020	NUM
admet-854	166	53	)	)	PUNCT
admet-854	166	54	149	149	NUM
admet-854	166	55	-	-	SYM
admet-854	166	56	175	175	NUM
admet-854	166	57	amantadine	amantadine	NOUN
admet-854	166	58	binding	bind	VERB
admet-854	166	59	to	to	ADP
admet-854	166	60	the	the	DET
admet-854	166	61	enzymes	enzyme	NOUN
admet-854	166	62	regulated	regulate	VERB
admet-854	166	63	in	in	ADP
admet-854	166	64	parkinson	parkinson	NOUN
admet-854	166	65	’s	’s	PART
admet-854	166	66	disease	disease	NOUN
admet-854	166	67	doi	doi	NOUN
admet-854	166	68	:	:	PUNCT
admet-854	166	69	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	166	70	157	157	NUM
admet-854	166	71	region	region	NOUN
admet-854	166	72	(	(	PUNCT
admet-854	166	73	arg138	arg138	PROPN
admet-854	166	74	and	and	CCONJ
admet-854	166	75	asp140	asp140	PROPN
admet-854	166	76	)	)	PUNCT
admet-854	166	77	.	.	PUNCT
admet-854	167	1	most	most	ADJ
admet-854	167	2	of	of	ADP
admet-854	167	3	the	the	DET
admet-854	167	4	residues	residue	NOUN
admet-854	167	5	that	that	PRON
admet-854	167	6	interact	interact	VERB
admet-854	167	7	with	with	ADP
admet-854	167	8	ionized	ionized	ADJ
admet-854	167	9	amantadine	amantadine	NOUN
admet-854	167	10	are	be	AUX
admet-854	167	11	amp	amp	NOUN
admet-854	167	12	binding	bind	VERB
admet-854	167	13	residues	residue	NOUN
admet-854	167	14	–	–	PUNCT
admet-854	167	15	gly64	gly64	NOUN
admet-854	167	16	,	,	PUNCT
admet-854	167	17	glu65	glu65	NOUN
admet-854	167	18	,	,	PUNCT
admet-854	167	19	leu66	leu66	PROPN
admet-854	167	20	,	,	PUNCT
admet-854	167	21	val67	val67	PROPN
admet-854	167	22	,	,	PUNCT
admet-854	167	23	arg	arg	NOUN
admet-854	167	24	138	138	NUM
admet-854	167	25	,	,	PUNCT
admet-854	167	26	and	and	CCONJ
admet-854	167	27	arg	arg	VERB
admet-854	167	28	149	149	NUM
admet-854	167	29	(	(	PUNCT
admet-854	167	30	figure	figure	NOUN
admet-854	167	31	6	6	NUM
admet-854	167	32	)	)	PUNCT
admet-854	167	33	.	.	PUNCT
admet-854	168	1	met61	met61	VERB
admet-854	168	2	:o	:o	PROPN
admet-854	168	3	-	-	PUNCT
admet-854	168	4	h5	h5	PROPN
admet-854	168	5	2.01	2.01	NUM
admet-854	168	6	å	å	NOUN
admet-854	168	7	asp140	asp140	ADJ
admet-854	168	8	:	:	PUNCT
admet-854	168	9	od2	od2	NOUN
admet-854	168	10	-	-	PUNCT
admet-854	168	11	h27	h27	NOUN
admet-854	168	12	2.10	2.10	NUM
admet-854	168	13	å	å	NOUN
admet-854	168	14	asp140	asp140	ADJ
admet-854	168	15	:	:	PUNCT
admet-854	168	16	od2	od2	NOUN
admet-854	168	17	-	-	PUNCT
admet-854	168	18	h28	h28	NOUN
admet-854	168	19	2.07	2.07	NUM
admet-854	168	20	å	å	NOUN
admet-854	168	21	met61	met61	NOUN
admet-854	168	22	4.02	4.02	NUM
admet-854	168	23	å	å	PRON
admet-854	168	24	leu66	leu66	PROPN
admet-854	168	25	-	-	PUNCT
admet-854	168	26	c9	c9	NOUN
admet-854	168	27	5.10	5.10	NUM
admet-854	168	28	å	å	PROPN
admet-854	168	29	(	(	PUNCT
admet-854	168	30	a	a	NOUN
admet-854	168	31	)	)	PUNCT
admet-854	168	32	(	(	PUNCT
admet-854	168	33	b	b	X
admet-854	168	34	)	)	PUNCT
admet-854	168	35	(	(	PUNCT
admet-854	168	36	c	c	X
admet-854	168	37	)	)	PUNCT
admet-854	168	38	figure	figure	NOUN
admet-854	168	39	6	6	NUM
admet-854	168	40	.	.	PUNCT
admet-854	168	41	interactions	interaction	NOUN
admet-854	168	42	of	of	ADP
admet-854	168	43	ionized	ionized	ADJ
admet-854	168	44	amantadine	amantadine	NOUN
admet-854	168	45	with	with	ADP
admet-854	168	46	zebrafish	zebrafish	PROPN
admet-854	168	47	ak1	ak1	PROPN
admet-854	168	48	,	,	PUNCT
admet-854	168	49	pdb	pdb	PROPN
admet-854	168	50	i	i	PROPN
admet-854	168	51	d	d	PROPN
admet-854	168	52	5xz2	5xz2	PROPN
admet-854	168	53	.	.	PUNCT
admet-854	169	1	(	(	PUNCT
admet-854	169	2	a	a	X
admet-854	169	3	)	)	PUNCT
admet-854	169	4	3d	3d	NUM
admet-854	169	5	display	display	NOUN
admet-854	169	6	of	of	ADP
admet-854	169	7	ionized	ionize	VERB
admet-854	169	8	amantadine	amantadine	NOUN
admet-854	169	9	interaction	interaction	NOUN
admet-854	169	10	as	as	ADP
admet-854	169	11	ligand	ligand	NOUN
admet-854	169	12	with	with	ADP
admet-854	169	13	the	the	DET
admet-854	169	14	5xz2	5xz2	NUM
admet-854	169	15	residues	residue	NOUN
admet-854	169	16	;	;	PUNCT
admet-854	169	17	(	(	PUNCT
admet-854	169	18	b	b	X
admet-854	169	19	)	)	PUNCT
admet-854	169	20	code	code	NOUN
admet-854	169	21	color	color	NOUN
admet-854	169	22	for	for	ADP
admet-854	169	23	interactions	interaction	NOUN
admet-854	169	24	:	:	PUNCT
admet-854	169	25	in	in	ADP
admet-854	169	26	green	green	NOUN
admet-854	169	27	are	be	AUX
admet-854	169	28	shown	show	VERB
admet-854	169	29	conventional	conventional	ADJ
admet-854	169	30	hydrogen	hydrogen	NOUN
admet-854	169	31	bonds	bond	NOUN
admet-854	169	32	,	,	PUNCT
admet-854	169	33	orange	orange	ADJ
admet-854	169	34	–	–	PUNCT
admet-854	169	35	salt	salt	NOUN
admet-854	169	36	bridge	bridge	NOUN
admet-854	169	37	,	,	PUNCT
admet-854	169	38	light	light	ADJ
admet-854	169	39	green	green	ADJ
admet-854	169	40	–	–	PUNCT
admet-854	169	41	van	van	PROPN
admet-854	169	42	der	der	NOUN
admet-854	169	43	waals	waal	NOUN
admet-854	169	44	forces	force	NOUN
admet-854	169	45	,	,	PUNCT
admet-854	169	46	mauve	mauve	NOUN
admet-854	169	47	–	–	PUNCT
admet-854	169	48	alkyl	alkyl	ADJ
admet-854	169	49	hydrophobic	hydrophobic	NOUN
admet-854	169	50	interactions	interaction	NOUN
admet-854	169	51	;	;	PUNCT
admet-854	169	52	(	(	PUNCT
admet-854	169	53	c	c	X
admet-854	169	54	)	)	PUNCT
admet-854	169	55	the	the	DET
admet-854	169	56	distances	distance	NOUN
admet-854	169	57	(	(	PUNCT
admet-854	169	58	å	å	NOUN
admet-854	169	59	)	)	PUNCT
admet-854	169	60	of	of	ADP
admet-854	169	61	the	the	DET
admet-854	169	62	5xz2	5xz2	NUM
admet-854	169	63	ionized	ionized	ADJ
admet-854	169	64	amantadine	amantadine	NOUN
admet-854	169	65	interactions	interaction	NOUN
admet-854	169	66	.	.	PUNCT
admet-854	170	1	molecular	molecular	ADJ
admet-854	170	2	docking	docking	NOUN
admet-854	170	3	of	of	ADP
admet-854	170	4	ionized	ionize	VERB
admet-854	170	5	amantadine	amantadine	NOUN
admet-854	170	6	with	with	ADP
admet-854	170	7	human	human	ADJ
admet-854	170	8	ak2	ak2	NOUN
admet-854	170	9	human	human	NOUN
admet-854	170	10	ak2	ak2	PROPN
admet-854	170	11	(	(	PUNCT
admet-854	170	12	pdb	pdb	PROPN
admet-854	170	13	i	i	PROPN
admet-854	170	14	d	d	PROPN
admet-854	170	15	2c9y	2c9y	NOUN
admet-854	170	16	)	)	PUNCT
admet-854	170	17	shows	show	VERB
admet-854	170	18	different	different	ADJ
admet-854	170	19	interactions	interaction	NOUN
admet-854	170	20	with	with	ADP
admet-854	170	21	the	the	DET
admet-854	170	22	two	two	NUM
admet-854	170	23	forms	form	NOUN
admet-854	170	24	of	of	ADP
admet-854	170	25	amantadine	amantadine	NOUN
admet-854	170	26	.	.	PUNCT
admet-854	171	1	the	the	DET
admet-854	171	2	–	–	PUNCT
admet-854	171	3	nh3	nh3	NOUN
admet-854	171	4	+	+	NOUN
admet-854	171	5	group	group	NOUN
admet-854	171	6	forms	form	VERB
admet-854	171	7	a	a	DET
admet-854	171	8	conventional	conventional	ADJ
admet-854	171	9	hydrogen	hydrogen	NOUN
admet-854	171	10	bond	bond	NOUN
admet-854	171	11	with	with	ADP
admet-854	171	12	a	a	DET
admet-854	171	13	residue	residue	NOUN
admet-854	171	14	from	from	ADP
admet-854	171	15	the	the	DET
admet-854	171	16	amp	amp	NOUN
admet-854	171	17	binding	bind	VERB
admet-854	171	18	region	region	NOUN
admet-854	171	19	(	(	PUNCT
admet-854	171	20	val74	val74	NOUN
admet-854	171	21	)	)	PUNCT
admet-854	171	22	and	and	CCONJ
admet-854	171	23	two	two	NUM
admet-854	171	24	electrostatic	electrostatic	ADJ
admet-854	171	25	interactions	interaction	NOUN
admet-854	171	26	with	with	ADP
admet-854	171	27	asp76	asp76	NOUN
admet-854	171	28	.	.	PUNCT
admet-854	172	1	two	two	NUM
admet-854	172	2	residues	residue	NOUN
admet-854	172	3	from	from	ADP
admet-854	172	4	the	the	DET
admet-854	172	5	amp	amp	NOUN
admet-854	172	6	binding	bind	VERB
admet-854	172	7	region	region	NOUN
admet-854	172	8	form	form	NOUN
admet-854	172	9	alkyl	alkyl	NOUN
admet-854	172	10	interactions	interaction	NOUN
admet-854	172	11	(	(	PUNCT
admet-854	172	12	arg103	arg103	NOUN
admet-854	172	13	and	and	CCONJ
admet-854	172	14	phe101	phe101	PROPN
admet-854	172	15	)	)	PUNCT
admet-854	172	16	.	.	PUNCT
admet-854	173	1	unlike	unlike	ADP
admet-854	173	2	unionized	unionize	VERB
admet-854	173	3	amantadine	amantadine	NOUN
admet-854	173	4	,	,	PUNCT
admet-854	173	5	the	the	DET
admet-854	173	6	ionized	ionized	ADJ
admet-854	173	7	amantadine	amantadine	NOUN
admet-854	173	8	shows	show	VERB
admet-854	173	9	a	a	DET
admet-854	173	10	better	well	ADJ
admet-854	173	11	match	match	NOUN
admet-854	173	12	with	with	ADP
admet-854	173	13	the	the	DET
admet-854	173	14	residues	residue	NOUN
admet-854	173	15	from	from	ADP
admet-854	173	16	the	the	DET
admet-854	173	17	catalytic	catalytic	ADJ
admet-854	173	18	site	site	NOUN
admet-854	173	19	.	.	PUNCT
admet-854	174	1	ionized	ionized	ADJ
admet-854	174	2	amantadine	amantadine	NOUN
admet-854	174	3	interacts	interact	VERB
admet-854	174	4	with	with	ADP
admet-854	174	5	five	five	NUM
admet-854	174	6	amp	amp	NOUN
admet-854	174	7	binding	bind	VERB
admet-854	174	8	residues	residue	NOUN
admet-854	174	9	–	–	PUNCT
admet-854	174	10	thr44	thr44	NOUN
admet-854	174	11	,	,	PUNCT
admet-854	174	12	val74	val74	NOUN
admet-854	174	13	,	,	PUNCT
admet-854	174	14	phe101	phe101	PROPN
admet-854	174	15	,	,	PUNCT
admet-854	174	16	arg103	arg103	PROPN
admet-854	174	17	,	,	PUNCT
admet-854	174	18	and	and	CCONJ
admet-854	174	19	gln107	gln107	PROPN
admet-854	174	20	(	(	PUNCT
admet-854	174	21	figure	figure	NOUN
admet-854	174	22	7	7	NUM
admet-854	174	23	)	)	PUNCT
admet-854	174	24	.	.	PUNCT
admet-854	175	1	val74	val74	PROPN
admet-854	175	2	:o	:o	PROPN
admet-854	175	3	-	-	PUNCT
admet-854	175	4	h5	h5	PROPN
admet-854	175	5	1.96	1.96	NUM
admet-854	175	6	å	å	PROPN
admet-854	175	7	asp76	asp76	NOUN
admet-854	175	8	:	:	PUNCT
admet-854	175	9	od1	od1	NOUN
admet-854	175	10	-	-	PUNCT
admet-854	175	11	h27	h27	NOUN
admet-854	175	12	2.17	2.17	NUM
admet-854	175	13	å	å	PRON
admet-854	175	14	asp76	asp76	NOUN
admet-854	175	15	:	:	PUNCT
admet-854	175	16	od1	od1	NOUN
admet-854	175	17	-	-	PUNCT
admet-854	175	18	h28	h28	NOUN
admet-854	175	19	2.15	2.15	NUM
admet-854	175	20	å	å	PROPN
admet-854	175	21	val79	val79	VERB
admet-854	175	22	5.40	5.40	NUM
admet-854	175	23	å	å	PROPN
admet-854	175	24	val79	val79	VERB
admet-854	175	25	4.46	4.46	NUM
admet-854	175	26	å	å	PROPN
admet-854	175	27	val79	val79	NOUN
admet-854	175	28	-	-	PUNCT
admet-854	175	29	c9	c9	NOUN
admet-854	175	30	3.69	3.69	NUM
admet-854	175	31	å	å	PROPN
admet-854	175	32	arg103	arg103	PROPN
admet-854	175	33	4.76	4.76	NUM
admet-854	175	34	å	å	PROPN
admet-854	175	35	phe101	phe101	PROPN
admet-854	175	36	4.64	4.64	NUM
admet-854	175	37	å	å	PROPN
admet-854	175	38	(	(	PUNCT
admet-854	175	39	a	a	NOUN
admet-854	175	40	)	)	PUNCT
admet-854	175	41	(	(	PUNCT
admet-854	175	42	b	b	X
admet-854	175	43	)	)	PUNCT
admet-854	175	44	(	(	PUNCT
admet-854	175	45	c	c	X
admet-854	175	46	)	)	PUNCT
admet-854	175	47	figure	figure	NOUN
admet-854	175	48	7	7	NUM
admet-854	175	49	.	.	PUNCT
admet-854	175	50	interactions	interaction	NOUN
admet-854	175	51	of	of	ADP
admet-854	175	52	ionized	ionized	ADJ
admet-854	175	53	amantadine	amantadine	NOUN
admet-854	175	54	with	with	ADP
admet-854	175	55	human	human	ADJ
admet-854	175	56	ak2	ak2	NOUN
admet-854	175	57	,	,	PUNCT
admet-854	175	58	pdb	pdb	PROPN
admet-854	175	59	i	i	PROPN
admet-854	175	60	d	d	PROPN
admet-854	175	61	2c9y	2c9y	PROPN
admet-854	175	62	.	.	PUNCT
admet-854	176	1	(	(	PUNCT
admet-854	176	2	a	a	X
admet-854	176	3	)	)	PUNCT
admet-854	176	4	3d	3d	NUM
admet-854	176	5	display	display	NOUN
admet-854	176	6	of	of	ADP
admet-854	176	7	ionized	ionize	VERB
admet-854	176	8	amantadine	amantadine	NOUN
admet-854	176	9	interaction	interaction	NOUN
admet-854	176	10	as	as	ADP
admet-854	176	11	ligand	ligand	NOUN
admet-854	176	12	with	with	ADP
admet-854	176	13	the	the	DET
admet-854	176	14	2c9y	2c9y	NOUN
admet-854	176	15	residues	residue	NOUN
admet-854	176	16	;	;	PUNCT
admet-854	176	17	(	(	PUNCT
admet-854	176	18	b	b	X
admet-854	176	19	)	)	PUNCT
admet-854	176	20	code	code	NOUN
admet-854	176	21	color	color	NOUN
admet-854	176	22	for	for	ADP
admet-854	176	23	interactions	interaction	NOUN
admet-854	176	24	:	:	PUNCT
admet-854	176	25	in	in	ADP
admet-854	176	26	green	green	NOUN
admet-854	176	27	are	be	AUX
admet-854	176	28	shown	show	VERB
admet-854	176	29	conventional	conventional	ADJ
admet-854	176	30	hydrogen	hydrogen	NOUN
admet-854	176	31	bonds	bond	NOUN
admet-854	176	32	,	,	PUNCT
admet-854	176	33	orange	orange	ADJ
admet-854	176	34	–	–	PUNCT
admet-854	176	35	salt	salt	NOUN
admet-854	176	36	bridge	bridge	NOUN
admet-854	176	37	,	,	PUNCT
admet-854	176	38	light	light	ADJ
admet-854	176	39	green	green	ADJ
admet-854	176	40	–	–	PUNCT
admet-854	176	41	van	van	PROPN
admet-854	176	42	der	der	NOUN
admet-854	176	43	waals	waal	NOUN
admet-854	176	44	forces	force	NOUN
admet-854	176	45	,	,	PUNCT
admet-854	176	46	mauve	mauve	NOUN
admet-854	176	47	–	–	PUNCT
admet-854	176	48	alkyl	alkyl	ADJ
admet-854	176	49	hydrophobic	hydrophobic	NOUN
admet-854	176	50	interactions	interaction	NOUN
admet-854	176	51	;	;	PUNCT
admet-854	176	52	(	(	PUNCT
admet-854	176	53	c	c	X
admet-854	176	54	)	)	PUNCT
admet-854	176	55	the	the	DET
admet-854	176	56	distances	distance	NOUN
admet-854	176	57	(	(	PUNCT
admet-854	176	58	å	å	NOUN
admet-854	176	59	)	)	PUNCT
admet-854	176	60	of	of	ADP
admet-854	176	61	the	the	DET
admet-854	176	62	2c9y	2c9y	ADV
admet-854	176	63	-	-	PUNCT
admet-854	176	64	ionized	ionize	VERB
admet-854	176	65	amantadine	amantadine	NOUN
admet-854	176	66	interactions	interaction	NOUN
admet-854	176	67	.	.	PUNCT
admet-854	177	1	molecular	molecular	ADJ
admet-854	177	2	docking	docking	NOUN
admet-854	177	3	of	of	ADP
admet-854	177	4	ionized	ionize	VERB
admet-854	177	5	amantadine	amantadine	NOUN
admet-854	177	6	with	with	ADP
admet-854	177	7	human	human	ADJ
admet-854	177	8	ak5	ak5	NOUN
admet-854	177	9	unlike	unlike	ADP
admet-854	177	10	unionized	unionized	ADJ
admet-854	177	11	amantadine	amantadine	NOUN
admet-854	177	12	,	,	PUNCT
admet-854	177	13	the	the	DET
admet-854	177	14	ionized	ionized	ADJ
admet-854	177	15	amantadine	amantadine	NOUN
admet-854	177	16	interacts	interact	VERB
admet-854	177	17	with	with	ADP
admet-854	177	18	human	human	ADJ
admet-854	177	19	ak5	ak5	NOUN
admet-854	177	20	(	(	PUNCT
admet-854	177	21	pdb	pdb	PROPN
admet-854	177	22	i	i	PROPN
admet-854	177	23	d	d	PROPN
admet-854	177	24	2bwj	2bwj	NUM
admet-854	177	25	-	-	NOUN
admet-854	177	26	chain	chain	NOUN
admet-854	177	27	b	b	NOUN
admet-854	177	28	)	)	PUNCT
admet-854	177	29	residues	residue	NOUN
admet-854	177	30	that	that	PRON
admet-854	177	31	do	do	AUX
admet-854	177	32	not	not	PART
admet-854	177	33	belong	belong	VERB
admet-854	177	34	to	to	ADP
admet-854	177	35	the	the	DET
admet-854	177	36	domains	domain	NOUN
admet-854	177	37	involved	involve	VERB
admet-854	177	38	in	in	ADP
admet-854	177	39	catalysis	catalysis	NOUN
admet-854	177	40	.	.	PUNCT
admet-854	178	1	the	the	DET
admet-854	178	2	van	van	PROPN
admet-854	178	3	der	der	NOUN
admet-854	178	4	waals	waal	NOUN
admet-854	178	5	forces	force	NOUN
admet-854	178	6	are	be	AUX
admet-854	178	7	observed	observe	VERB
admet-854	178	8	with	with	ADP
admet-854	178	9	two	two	NUM
admet-854	178	10	glycines	glycine	NOUN
admet-854	178	11	in	in	ADP
admet-854	178	12	the	the	DET
admet-854	178	13	phosphate	phosphate	NOUN
admet-854	178	14	-	-	PUNCT
admet-854	178	15	binding	bind	VERB
admet-854	178	16	loop	loop	NOUN
admet-854	178	17	(	(	PUNCT
admet-854	178	18	p	p	NOUN
admet-854	178	19	-	-	PUNCT
admet-854	178	20	loop	loop	NOUN
admet-854	178	21	)	)	PUNCT
admet-854	178	22	(	(	PUNCT
admet-854	178	23	figure	figure	NOUN
admet-854	178	24	8)	8)	NUM
admet-854	178	25	.	.	PUNCT
admet-854	179	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	179	2	mihaela	mihaela	PROPN
admet-854	179	3	ileana	ileana	PROPN
admet-854	179	4	ionescu	ionescu	PROPN
admet-854	179	5	admet	admet	PROPN
admet-854	179	6	&	&	CCONJ
admet-854	179	7	dmpk	dmpk	PROPN
admet-854	179	8	8(2	8(2	NUM
admet-854	179	9	)	)	PUNCT
admet-854	179	10	(	(	PUNCT
admet-854	179	11	2020	2020	NUM
admet-854	179	12	)	)	PUNCT
admet-854	179	13	149	149	NUM
admet-854	179	14	-	-	SYM
admet-854	179	15	175	175	NUM
admet-854	179	16	158	158	NUM
admet-854	179	17	asp122	asp122	PROPN
admet-854	179	18	:	:	PUNCT
admet-854	179	19	od1	od1	NOUN
admet-854	179	20	-	-	PUNCT
admet-854	179	21	h27	h27	NOUN
admet-854	179	22	1.98	1.98	NUM
admet-854	179	23	å	å	PROPN
admet-854	179	24	asp122	asp122	PROPN
admet-854	179	25	:	:	PUNCT
admet-854	179	26	od1	od1	NOUN
admet-854	179	27	-	-	PUNCT
admet-854	179	28	h5	h5	NOUN
admet-854	179	29	2.17	2.17	NUM
admet-854	179	30	å	å	PROPN
admet-854	179	31	met128	met128	PROPN
admet-854	179	32	5.35	5.35	NUM
admet-854	179	33	å	å	PROPN
admet-854	179	34	cys120	cys120	PROPN
admet-854	179	35	-	-	PUNCT
admet-854	179	36	c10	c10	VERB
admet-854	179	37	5.26	5.26	NUM
admet-854	179	38	å	å	PROPN
admet-854	179	39	ile164	ile164	NOUN
admet-854	179	40	-	-	PUNCT
admet-854	179	41	c10	c10	VERB
admet-854	179	42	5.40	5.40	NUM
admet-854	179	43	å	å	PROPN
admet-854	179	44	tyr156	tyr156	PROPN
admet-854	179	45	4.65	4.65	NUM
admet-854	179	46	å	å	PROPN
admet-854	179	47	tyr156	tyr156	PROPN
admet-854	179	48	4.66	4.66	NUM
admet-854	179	49	å	å	PROPN
admet-854	179	50	tyr156	tyr156	PROPN
admet-854	179	51	-	-	PUNCT
admet-854	179	52	c10	c10	VERB
admet-854	179	53	4.40	4.40	NUM
admet-854	179	54	å	å	PROPN
admet-854	179	55	tyr157	tyr157	PROPN
admet-854	179	56	5.08	5.08	NUM
admet-854	179	57	å	å	PROPN
admet-854	179	58	cys123	cys123	NOUN
admet-854	179	59	:	:	PUNCT
admet-854	179	60	hn	hn	PROPN
admet-854	179	61	-	-	PUNCT
admet-854	179	62	h5	h5	PROPN
admet-854	179	63	2.35	2.35	NUM
admet-854	179	64	å	å	NOUN
admet-854	179	65	(	(	PUNCT
admet-854	179	66	a	a	NOUN
admet-854	179	67	)	)	PUNCT
admet-854	179	68	(	(	PUNCT
admet-854	179	69	b	b	X
admet-854	179	70	)	)	PUNCT
admet-854	179	71	(	(	PUNCT
admet-854	179	72	c	c	X
admet-854	179	73	)	)	PUNCT
admet-854	179	74	figure	figure	NOUN
admet-854	179	75	8	8	NUM
admet-854	179	76	.	.	PUNCT
admet-854	180	1	interactions	interaction	NOUN
admet-854	180	2	of	of	ADP
admet-854	180	3	amantadine	amantadine	NOUN
admet-854	180	4	with	with	ADP
admet-854	180	5	human	human	ADJ
admet-854	180	6	ak5	ak5	NOUN
admet-854	180	7	,	,	PUNCT
admet-854	180	8	pdb	pdb	PROPN
admet-854	181	1	i	i	PROPN
admet-854	181	2	d	d	PROPN
admet-854	181	3	2bwj	2bwj	NUM
admet-854	181	4	.	.	PUNCT
admet-854	182	1	(	(	PUNCT
admet-854	182	2	a	a	X
admet-854	182	3	)	)	PUNCT
admet-854	182	4	3d	3d	NUM
admet-854	182	5	display	display	NOUN
admet-854	182	6	of	of	ADP
admet-854	182	7	ionized	ionize	VERB
admet-854	182	8	amantadine	amantadine	NOUN
admet-854	182	9	interaction	interaction	NOUN
admet-854	182	10	as	as	ADP
admet-854	182	11	ligand	ligand	NOUN
admet-854	182	12	with	with	ADP
admet-854	182	13	the	the	DET
admet-854	182	14	2bwj	2bwj	NUM
admet-854	182	15	residues	residue	NOUN
admet-854	182	16	;	;	PUNCT
admet-854	182	17	(	(	PUNCT
admet-854	182	18	b	b	X
admet-854	182	19	)	)	PUNCT
admet-854	182	20	code	code	NOUN
admet-854	182	21	color	color	NOUN
admet-854	182	22	for	for	ADP
admet-854	182	23	interactions	interaction	NOUN
admet-854	182	24	:	:	PUNCT
admet-854	182	25	in	in	ADP
admet-854	182	26	orange	orange	NOUN
admet-854	182	27	are	be	AUX
admet-854	182	28	shown	show	VERB
admet-854	182	29	salt	salt	NOUN
admet-854	182	30	bridge	bridge	NOUN
admet-854	182	31	,	,	PUNCT
admet-854	182	32	light	light	ADJ
admet-854	182	33	green	green	ADJ
admet-854	182	34	–	–	PUNCT
admet-854	182	35	van	van	PROPN
admet-854	182	36	der	der	NOUN
admet-854	182	37	waals	waal	NOUN
admet-854	182	38	forces	force	NOUN
admet-854	182	39	,	,	PUNCT
admet-854	182	40	mauve	mauve	NOUN
admet-854	182	41	–	–	PUNCT
admet-854	182	42	alkyl	alkyl	ADJ
admet-854	182	43	hydrophobic	hydrophobic	NOUN
admet-854	182	44	interactions	interaction	NOUN
admet-854	182	45	,	,	PUNCT
admet-854	182	46	red	red	ADJ
admet-854	182	47	–	–	PUNCT
admet-854	182	48	unfavorable	unfavorable	ADJ
admet-854	182	49	donor	donor	NOUN
admet-854	182	50	-	-	PUNCT
admet-854	182	51	donor	donor	NOUN
admet-854	182	52	interactions	interaction	NOUN
admet-854	182	53	;	;	PUNCT
admet-854	182	54	(	(	PUNCT
admet-854	182	55	c	c	X
admet-854	182	56	)	)	PUNCT
admet-854	182	57	the	the	DET
admet-854	182	58	distances	distance	NOUN
admet-854	182	59	(	(	PUNCT
admet-854	182	60	å	å	NOUN
admet-854	182	61	)	)	PUNCT
admet-854	182	62	of	of	ADP
admet-854	182	63	the	the	DET
admet-854	182	64	2bwj	2bwj	NUM
admet-854	182	65	ionized	ionize	VERB
admet-854	182	66	amantadine	amantadine	NOUN
admet-854	182	67	interactions	interaction	NOUN
admet-854	182	68	.	.	PUNCT
admet-854	183	1	molecular	molecular	ADJ
admet-854	183	2	docking	docking	NOUN
admet-854	183	3	of	of	ADP
admet-854	183	4	ionized	ionize	VERB
admet-854	183	5	amantadine	amantadine	NOUN
admet-854	183	6	with	with	ADP
admet-854	183	7	bacterial	bacterial	ADJ
admet-854	183	8	aks	ak	NOUN
admet-854	183	9	a	a	DET
admet-854	183	10	comparison	comparison	NOUN
admet-854	183	11	of	of	ADP
admet-854	183	12	human	human	ADJ
admet-854	183	13	aks	ak	NOUN
admet-854	183	14	with	with	ADP
admet-854	183	15	their	their	PRON
admet-854	183	16	bacterial	bacterial	ADJ
admet-854	183	17	counterparts	counterpart	NOUN
admet-854	183	18	was	be	AUX
admet-854	183	19	necessary	necessary	ADJ
admet-854	183	20	to	to	PART
admet-854	183	21	draw	draw	VERB
admet-854	183	22	a	a	DET
admet-854	183	23	valid	valid	ADJ
admet-854	183	24	conclusion	conclusion	NOUN
admet-854	183	25	about	about	ADP
admet-854	183	26	the	the	DET
admet-854	183	27	specificity	specificity	NOUN
admet-854	183	28	of	of	ADP
admet-854	183	29	human	human	ADJ
admet-854	183	30	aks	ak	NOUN
admet-854	183	31	for	for	ADP
admet-854	183	32	amantadine	amantadine	NOUN
admet-854	183	33	.	.	PUNCT
admet-854	184	1	bacterial	bacterial	ADJ
admet-854	184	2	aks	ak	NOUN
admet-854	184	3	with	with	ADP
admet-854	184	4	x	x	NOUN
admet-854	184	5	-	-	NOUN
admet-854	184	6	ray	ray	ADJ
admet-854	184	7	3d	3d	NOUN
admet-854	184	8	structure	structure	NOUN
admet-854	184	9	deposited	deposit	VERB
admet-854	184	10	in	in	ADP
admet-854	184	11	pdb	pdb	PROPN
admet-854	184	12	are	be	AUX
admet-854	184	13	much	much	ADV
admet-854	184	14	numerous	numerous	ADJ
admet-854	184	15	than	than	ADP
admet-854	184	16	aks	ak	NOUN
admet-854	184	17	from	from	ADP
admet-854	184	18	eucaryotes	eucaryote	NOUN
admet-854	184	19	.	.	PUNCT
admet-854	185	1	ak	ak	PROPN
admet-854	185	2	from	from	ADP
admet-854	185	3	e.coli	e.coli	NOUN
admet-854	185	4	(	(	PUNCT
admet-854	185	5	pdb	pdb	PROPN
admet-854	185	6	i	i	PROPN
admet-854	185	7	d	d	PROPN
admet-854	185	8	3hpq	3hpq	PROPN
admet-854	185	9	)	)	PUNCT
admet-854	185	10	interacts	interact	VERB
admet-854	185	11	with	with	ADP
admet-854	185	12	ionized	ionized	ADJ
admet-854	185	13	amantadine	amantadine	NOUN
admet-854	185	14	through	through	ADP
admet-854	185	15	residues	residue	NOUN
admet-854	185	16	that	that	PRON
admet-854	185	17	do	do	AUX
admet-854	185	18	not	not	PART
admet-854	185	19	belong	belong	VERB
admet-854	185	20	to	to	ADP
admet-854	185	21	the	the	DET
admet-854	185	22	catalytic	catalytic	ADJ
admet-854	185	23	site	site	NOUN
admet-854	185	24	.	.	PUNCT
admet-854	186	1	only	only	ADV
admet-854	186	2	ala8	ala8	PROPN
admet-854	186	3	(	(	PUNCT
admet-854	186	4	from	from	ADP
admet-854	186	5	the	the	DET
admet-854	186	6	p	p	NOUN
admet-854	186	7	-	-	PUNCT
admet-854	186	8	loop	loop	NOUN
admet-854	186	9	)	)	PUNCT
admet-854	186	10	forms	form	VERB
admet-854	186	11	two	two	NUM
admet-854	186	12	alkyl	alkyl	ADJ
admet-854	186	13	hydrophobic	hydrophobic	NOUN
admet-854	186	14	interactions	interaction	NOUN
admet-854	186	15	with	with	ADP
admet-854	186	16	ionized	ionized	ADJ
admet-854	186	17	amantadine	amantadine	NOUN
admet-854	186	18	(	(	PUNCT
admet-854	186	19	figure	figure	NOUN
admet-854	186	20	9	9	NUM
admet-854	186	21	)	)	PUNCT
admet-854	186	22	.	.	PUNCT
admet-854	187	1	phe109	phe109	VERB
admet-854	187	2	:o	:o	PROPN
admet-854	187	3	-	-	PUNCT
admet-854	187	4	h5	h5	PROPN
admet-854	187	5	3.07	3.07	NUM
admet-854	187	6	å	å	PROPN
admet-854	187	7	glu108	glu108	PROPN
admet-854	187	8	:	:	PUNCT
admet-854	187	9	oe2	oe2	PROPN
admet-854	187	10	-	-	NOUN
admet-854	187	11	h27	h27	NOUN
admet-854	187	12	2.16	2.16	NUM
admet-854	187	13	å	å	PROPN
admet-854	187	14	glu108	glu108	PROPN
admet-854	187	15	:	:	PUNCT
admet-854	187	16	oe2	oe2	PROPN
admet-854	187	17	-	-	PUNCT
admet-854	187	18	h25	h25	PROPN
admet-854	187	19	2.13	2.13	NUM
admet-854	187	20	å	å	PROPN
admet-854	187	21	asp110	asp110	PROPN
admet-854	187	22	:	:	PUNCT
admet-854	187	23	od1	od1	NOUN
admet-854	187	24	-	-	PUNCT
admet-854	187	25	h28	h28	NOUN
admet-854	187	26	1.89	1.89	NUM
admet-854	187	27	å	å	PROPN
admet-854	187	28	ala8	ala8	NOUN
admet-854	187	29	4.31	4.31	NUM
admet-854	187	30	å	å	DET
admet-854	187	31	ala8	ala8	NOUN
admet-854	187	32	-	-	PUNCT
admet-854	187	33	c9	c9	NOUN
admet-854	187	34	3.27	3.27	NUM
admet-854	187	35	å	å	PROPN
admet-854	187	36	tyr171	tyr171	PROPN
admet-854	187	37	-	-	PUNCT
admet-854	187	38	c9	c9	NOUN
admet-854	187	39	4.30	4.30	NUM
admet-854	187	40	å	å	PROPN
admet-854	187	41	his172	his172	PROPN
admet-854	187	42	5.36	5.36	NUM
admet-854	187	43	å	å	DET
admet-854	187	44	his172	his172	NOUN
admet-854	187	45	-	-	PUNCT
admet-854	187	46	c9	c9	NOUN
admet-854	187	47	5.39	5.39	NUM
admet-854	187	48	å	å	PROPN
admet-854	187	49	(	(	PUNCT
admet-854	187	50	a	a	NOUN
admet-854	187	51	)	)	PUNCT
admet-854	187	52	(	(	PUNCT
admet-854	187	53	b	b	X
admet-854	187	54	)	)	PUNCT
admet-854	187	55	(	(	PUNCT
admet-854	187	56	c	c	X
admet-854	187	57	)	)	PUNCT
admet-854	187	58	figure	figure	NOUN
admet-854	187	59	9	9	NUM
admet-854	187	60	.	.	PUNCT
admet-854	187	61	interactions	interaction	NOUN
admet-854	187	62	of	of	ADP
admet-854	187	63	ionized	ionized	ADJ
admet-854	187	64	amantadine	amantadine	NOUN
admet-854	187	65	with	with	ADP
admet-854	187	66	ak	ak	PROPN
admet-854	187	67	from	from	ADP
admet-854	187	68	e.coli	e.coli	NOUN
admet-854	187	69	,	,	PUNCT
admet-854	187	70	pdb	pdb	PROPN
admet-854	187	71	i	i	PROPN
admet-854	187	72	d	d	PROPN
admet-854	187	73	3hpq	3hpq	PROPN
admet-854	187	74	.	.	PUNCT
admet-854	188	1	(	(	PUNCT
admet-854	188	2	a	a	X
admet-854	188	3	)	)	PUNCT
admet-854	188	4	3d	3d	PROPN
admet-854	188	5	display	display	NOUN
admet-854	188	6	of	of	ADP
admet-854	188	7	amantadine	amantadine	NOUN
admet-854	188	8	interaction	interaction	NOUN
admet-854	188	9	as	as	ADP
admet-854	188	10	ligand	ligand	NOUN
admet-854	188	11	with	with	ADP
admet-854	188	12	the	the	DET
admet-854	188	13	3hpq	3hpq	PROPN
admet-854	188	14	residues	residue	NOUN
admet-854	188	15	;	;	PUNCT
admet-854	188	16	(	(	PUNCT
admet-854	188	17	b	b	X
admet-854	188	18	)	)	PUNCT
admet-854	188	19	code	code	NOUN
admet-854	188	20	color	color	NOUN
admet-854	188	21	for	for	ADP
admet-854	188	22	interactions	interaction	NOUN
admet-854	188	23	:	:	PUNCT
admet-854	188	24	in	in	ADP
admet-854	188	25	green	green	NOUN
admet-854	188	26	are	be	AUX
admet-854	188	27	shown	show	VERB
admet-854	188	28	conventional	conventional	ADJ
admet-854	188	29	hydrogen	hydrogen	NOUN
admet-854	188	30	bonds	bond	NOUN
admet-854	188	31	,	,	PUNCT
admet-854	188	32	orange	orange	ADJ
admet-854	188	33	–	–	PUNCT
admet-854	188	34	salt	salt	NOUN
admet-854	188	35	bridge	bridge	NOUN
admet-854	188	36	,	,	PUNCT
admet-854	188	37	light	light	ADJ
admet-854	188	38	green	green	ADJ
admet-854	188	39	–	–	PUNCT
admet-854	188	40	van	van	PROPN
admet-854	188	41	der	der	NOUN
admet-854	188	42	waals	waal	NOUN
admet-854	188	43	forces	force	NOUN
admet-854	188	44	,	,	PUNCT
admet-854	188	45	mauve	mauve	NOUN
admet-854	188	46	–	–	PUNCT
admet-854	188	47	alkyl	alkyl	ADJ
admet-854	188	48	hydrophobic	hydrophobic	NOUN
admet-854	188	49	interactions	interaction	NOUN
admet-854	188	50	;	;	PUNCT
admet-854	188	51	(	(	PUNCT
admet-854	188	52	c	c	X
admet-854	188	53	)	)	PUNCT
admet-854	188	54	the	the	DET
admet-854	188	55	distances	distance	NOUN
admet-854	188	56	(	(	PUNCT
admet-854	188	57	å	å	NOUN
admet-854	188	58	)	)	PUNCT
admet-854	188	59	of	of	ADP
admet-854	188	60	the	the	DET
admet-854	188	61	3hpq	3hpq	PROPN
admet-854	188	62	ionized	ionize	VERB
admet-854	188	63	amantadine	amantadine	NOUN
admet-854	188	64	interactions	interaction	NOUN
admet-854	188	65	.	.	PUNCT
admet-854	189	1	ak	ak	PROPN
admet-854	189	2	from	from	ADP
admet-854	189	3	b.	b.	PROPN
admet-854	189	4	stearothermophilus	stearothermophilus	PROPN
admet-854	189	5	(	(	PUNCT
admet-854	189	6	pdb	pdb	PROPN
admet-854	189	7	i	i	PROPN
admet-854	189	8	d	d	PROPN
admet-854	189	9	zip	zip	PROPN
admet-854	189	10	)	)	PUNCT
admet-854	189	11	interacts	interact	VERB
admet-854	189	12	with	with	ADP
admet-854	189	13	ionized	ionized	ADJ
admet-854	189	14	amantadine	amantadine	NOUN
admet-854	189	15	from	from	ADP
admet-854	189	16	two	two	NUM
admet-854	189	17	residues	residue	NOUN
admet-854	189	18	belonging	belong	VERB
admet-854	189	19	to	to	ADP
admet-854	189	20	the	the	DET
admet-854	189	21	lid	lid	NOUN
admet-854	189	22	region	region	NOUN
admet-854	189	23	–	–	PUNCT
admet-854	189	24	with	with	ADP
admet-854	189	25	arg162	arg162	PROPN
admet-854	189	26	by	by	ADP
admet-854	189	27	two	two	NUM
admet-854	189	28	electrostatic	electrostatic	ADJ
admet-854	189	29	interactions	interaction	NOUN
admet-854	189	30	and	and	CCONJ
admet-854	189	31	with	with	ADP
admet-854	189	32	arg160	arg160	PROPN
admet-854	189	33	by	by	ADP
admet-854	189	34	van	van	PROPN
admet-854	189	35	der	der	ADJ
admet-854	189	36	waals	waal	NOUN
admet-854	189	37	forces	force	NOUN
admet-854	189	38	.	.	PUNCT
admet-854	190	1	the	the	DET
admet-854	190	2	pro9	pro9	NOUN
admet-854	190	3	from	from	ADP
admet-854	190	4	the	the	DET
admet-854	190	5	p	p	PROPN
admet-854	190	6	-	-	PUNCT
admet-854	190	7	loop	loop	NOUN
admet-854	190	8	forms	form	NOUN
admet-854	190	9	alkyl	alkyl	ADJ
admet-854	190	10	interactions	interaction	NOUN
admet-854	190	11	with	with	ADP
admet-854	190	12	ionized	ionized	ADJ
admet-854	190	13	amantadine	amantadine	NOUN
admet-854	190	14	.	.	PUNCT
admet-854	191	1	also	also	ADV
admet-854	191	2	,	,	PUNCT
admet-854	191	3	four	four	NUM
admet-854	191	4	residues	residue	NOUN
admet-854	191	5	from	from	ADP
admet-854	191	6	the	the	DET
admet-854	191	7	nmp	nmp	NOUN
admet-854	191	8	binding	bind	VERB
admet-854	191	9	region	region	NOUN
admet-854	191	10	interact	interact	VERB
admet-854	191	11	with	with	ADP
admet-854	191	12	ionized	ionized	ADJ
admet-854	191	13	amantadine	amantadine	NOUN
admet-854	191	14	–	–	PUNCT
admet-854	191	15	met53	met53	PROPN
admet-854	191	16	,	,	PUNCT
admet-854	191	17	leu58	leu58	NOUN
admet-854	191	18	,	,	PUNCT
admet-854	191	19	gly56	gly56	NOUN
admet-854	191	20	,	,	PUNCT
admet-854	191	21	and	and	CCONJ
admet-854	191	22	arg171	arg171	PROPN
admet-854	191	23	.	.	PUNCT
admet-854	192	1	more	more	ADJ
admet-854	192	2	,	,	PUNCT
admet-854	192	3	five	five	NUM
admet-854	192	4	amp	amp	NOUN
admet-854	192	5	-	-	PUNCT
admet-854	192	6	binding	bind	VERB
admet-854	192	7	residues	residue	NOUN
admet-854	192	8	interact	interact	VERB
admet-854	192	9	with	with	ADP
admet-854	192	10	ionized	ionized	ADJ
admet-854	192	11	amantadine	amantadine	NOUN
admet-854	192	12	–	–	PUNCT
admet-854	192	13	gly56	gly56	NOUN
admet-854	192	14	,	,	PUNCT
admet-854	192	15	asp57	asp57	NOUN
admet-854	192	16	,	,	PUNCT
admet-854	192	17	leu58	leu58	NOUN
admet-854	192	18	,	,	PUNCT
admet-854	192	19	arg88	arg88	NOUN
admet-854	192	20	,	,	PUNCT
admet-854	192	21	and	and	CCONJ
admet-854	192	22	arg171	arg171	PROPN
admet-854	192	23	(	(	PUNCT
admet-854	192	24	figure	figure	NOUN
admet-854	192	25	10	10	NUM
admet-854	192	26	)	)	PUNCT
admet-854	192	27	.	.	PUNCT
admet-854	193	1	admet	admet	PROPN
admet-854	193	2	&	&	CCONJ
admet-854	193	3	dmpk	dmpk	PROPN
admet-854	193	4	8(2	8(2	NUM
admet-854	193	5	)	)	PUNCT
admet-854	193	6	(	(	PUNCT
admet-854	193	7	2020	2020	NUM
admet-854	193	8	)	)	PUNCT
admet-854	193	9	149	149	NUM
admet-854	193	10	-	-	SYM
admet-854	193	11	175	175	NUM
admet-854	193	12	amantadine	amantadine	NOUN
admet-854	193	13	binding	bind	VERB
admet-854	193	14	to	to	ADP
admet-854	193	15	the	the	DET
admet-854	193	16	enzymes	enzyme	NOUN
admet-854	193	17	regulated	regulate	VERB
admet-854	193	18	in	in	ADP
admet-854	193	19	parkinson	parkinson	NOUN
admet-854	193	20	’s	’s	PART
admet-854	193	21	disease	disease	NOUN
admet-854	193	22	doi	doi	PROPN
admet-854	193	23	:	:	PUNCT
admet-854	193	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	193	25	159	159	NUM
admet-854	193	26	met53	met53	PROPN
admet-854	193	27	:o	:o	PROPN
admet-854	193	28	-	-	PUNCT
admet-854	193	29	h5	h5	PROPN
admet-854	193	30	2.07	2.07	NUM
admet-854	193	31	å	å	PROPN
admet-854	193	32	asp162	asp162	NOUN
admet-854	193	33	:	:	PUNCT
admet-854	193	34	od2	od2	NOUN
admet-854	193	35	-	-	PUNCT
admet-854	193	36	h27	h27	NOUN
admet-854	193	37	2.12	2.12	NUM
admet-854	193	38	å	å	PROPN
admet-854	193	39	asp162	asp162	NOUN
admet-854	193	40	:	:	PUNCT
admet-854	193	41	od2	od2	NOUN
admet-854	193	42	-	-	PUNCT
admet-854	193	43	h28	h28	NOUN
admet-854	193	44	2.15	2.15	NUM
admet-854	194	1	å	å	PROPN
admet-854	195	1	arg171	arg171	PROPN
admet-854	195	2	5.23	5.23	NUM
admet-854	195	3	å	å	PROPN
admet-854	195	4	leu58	leu58	PROPN
admet-854	195	5	4.94	4.94	NUM
admet-854	195	6	å	å	PROPN
admet-854	195	7	pro9	pro9	PROPN
admet-854	195	8	-	-	PUNCT
admet-854	195	9	c10	c10	VERB
admet-854	195	10	4.78	4.78	NUM
admet-854	195	11	å	å	PROPN
admet-854	195	12	arg171	arg171	PROPN
admet-854	195	13	-	-	PUNCT
admet-854	195	14	c10	c10	VERB
admet-854	195	15	4.41	4.41	NUM
admet-854	195	16	å	å	PROPN
admet-854	195	17	(	(	PUNCT
admet-854	195	18	a	a	NOUN
admet-854	195	19	)	)	PUNCT
admet-854	195	20	(	(	PUNCT
admet-854	195	21	b	b	X
admet-854	195	22	)	)	PUNCT
admet-854	195	23	(	(	PUNCT
admet-854	195	24	c	c	X
admet-854	195	25	)	)	PUNCT
admet-854	195	26	figure	figure	NOUN
admet-854	195	27	10	10	NUM
admet-854	195	28	.	.	PUNCT
admet-854	196	1	interactions	interaction	NOUN
admet-854	196	2	of	of	ADP
admet-854	196	3	ionized	ionized	ADJ
admet-854	196	4	amantadine	amantadine	NOUN
admet-854	196	5	with	with	ADP
admet-854	196	6	ak	ak	PROPN
admet-854	196	7	from	from	ADP
admet-854	196	8	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	196	9	,	,	PUNCT
admet-854	196	10	pdb	pdb	PROPN
admet-854	196	11	i	i	PROPN
admet-854	196	12	d	d	PROPN
admet-854	196	13	1zip	1zip	PROPN
admet-854	196	14	.	.	PUNCT
admet-854	197	1	(	(	PUNCT
admet-854	197	2	a	a	X
admet-854	197	3	)	)	PUNCT
admet-854	197	4	3d	3d	PROPN
admet-854	197	5	display	display	NOUN
admet-854	197	6	of	of	ADP
admet-854	197	7	amantadine	amantadine	NOUN
admet-854	197	8	interaction	interaction	NOUN
admet-854	197	9	as	as	ADP
admet-854	197	10	ligand	ligand	NOUN
admet-854	197	11	with	with	ADP
admet-854	197	12	the	the	DET
admet-854	197	13	1zip	1zip	NUM
admet-854	197	14	residues	residue	NOUN
admet-854	197	15	;	;	PUNCT
admet-854	197	16	(	(	PUNCT
admet-854	197	17	b	b	X
admet-854	197	18	)	)	PUNCT
admet-854	197	19	code	code	NOUN
admet-854	197	20	color	color	NOUN
admet-854	197	21	for	for	ADP
admet-854	197	22	interactions	interaction	NOUN
admet-854	197	23	:	:	PUNCT
admet-854	197	24	in	in	ADP
admet-854	197	25	green	green	NOUN
admet-854	197	26	are	be	AUX
admet-854	197	27	shown	show	VERB
admet-854	197	28	conventional	conventional	ADJ
admet-854	197	29	hydrogen	hydrogen	NOUN
admet-854	197	30	bonds	bond	NOUN
admet-854	197	31	,	,	PUNCT
admet-854	197	32	orange	orange	ADJ
admet-854	197	33	–	–	PUNCT
admet-854	197	34	salt	salt	NOUN
admet-854	197	35	bridge	bridge	NOUN
admet-854	197	36	,	,	PUNCT
admet-854	197	37	light	light	ADJ
admet-854	197	38	green	green	ADJ
admet-854	197	39	–	–	PUNCT
admet-854	197	40	van	van	PROPN
admet-854	197	41	der	der	NOUN
admet-854	197	42	waals	waal	NOUN
admet-854	197	43	forces	force	NOUN
admet-854	197	44	,	,	PUNCT
admet-854	197	45	mauve	mauve	NOUN
admet-854	197	46	–	–	PUNCT
admet-854	197	47	alkyl	alkyl	ADJ
admet-854	197	48	hydrophobic	hydrophobic	NOUN
admet-854	197	49	interactions	interaction	NOUN
admet-854	197	50	;	;	PUNCT
admet-854	197	51	(	(	PUNCT
admet-854	197	52	c	c	X
admet-854	197	53	)	)	PUNCT
admet-854	197	54	the	the	DET
admet-854	197	55	distances	distance	NOUN
admet-854	197	56	(	(	PUNCT
admet-854	197	57	å	å	NOUN
admet-854	197	58	)	)	PUNCT
admet-854	197	59	of	of	ADP
admet-854	197	60	the	the	DET
admet-854	197	61	1zip	1zip	NUM
admet-854	197	62	ionized	ionize	VERB
admet-854	197	63	amantadine	amantadine	NOUN
admet-854	197	64	interactions	interaction	NOUN
admet-854	197	65	.	.	PUNCT
admet-854	198	1	comparison	comparison	NOUN
admet-854	198	2	of	of	ADP
admet-854	198	3	molecular	molecular	ADJ
admet-854	198	4	docking	docking	NOUN
admet-854	198	5	of	of	ADP
admet-854	198	6	ionized	ionize	VERB
admet-854	198	7	amantadine	amantadine	NOUN
admet-854	198	8	with	with	ADP
admet-854	198	9	the	the	DET
admet-854	198	10	aks	ak	NOUN
admet-854	198	11	studied	study	VERB
admet-854	198	12	the	the	DET
admet-854	198	13	overall	overall	ADJ
admet-854	198	14	comparison	comparison	NOUN
admet-854	198	15	of	of	ADP
admet-854	198	16	the	the	DET
admet-854	198	17	molecular	molecular	ADJ
admet-854	198	18	docking	docking	NOUN
admet-854	198	19	results	result	NOUN
admet-854	198	20	offers	offer	VERB
admet-854	198	21	a	a	DET
admet-854	198	22	better	well	ADJ
admet-854	198	23	view	view	NOUN
admet-854	198	24	of	of	ADP
admet-854	198	25	the	the	DET
admet-854	198	26	interactions	interaction	NOUN
admet-854	198	27	of	of	ADP
admet-854	198	28	the	the	DET
admet-854	198	29	two	two	NUM
admet-854	198	30	forms	form	NOUN
admet-854	198	31	of	of	ADP
admet-854	198	32	amantadine	amantadine	NOUN
admet-854	198	33	with	with	ADP
admet-854	198	34	the	the	DET
admet-854	198	35	human	human	ADJ
admet-854	198	36	and	and	CCONJ
admet-854	198	37	bacterial	bacterial	ADJ
admet-854	198	38	aks	ak	NOUN
admet-854	198	39	.	.	PUNCT
admet-854	199	1	as	as	SCONJ
admet-854	199	2	the	the	DET
admet-854	199	3	physiological	physiological	ADJ
admet-854	199	4	form	form	NOUN
admet-854	199	5	of	of	ADP
admet-854	199	6	amantadine	amantadine	NOUN
admet-854	199	7	is	be	AUX
admet-854	199	8	ionized	ionize	VERB
admet-854	199	9	,	,	PUNCT
admet-854	199	10	the	the	DET
admet-854	199	11	comparison	comparison	NOUN
admet-854	199	12	of	of	ADP
admet-854	199	13	molecular	molecular	ADJ
admet-854	199	14	docking	docking	NOUN
admet-854	199	15	results	result	NOUN
admet-854	199	16	with	with	ADP
admet-854	199	17	both	both	DET
admet-854	199	18	forms	form	NOUN
admet-854	199	19	of	of	ADP
admet-854	199	20	the	the	DET
admet-854	199	21	drug	drug	NOUN
admet-854	199	22	has	have	AUX
admet-854	199	23	advanced	advance	VERB
admet-854	199	24	the	the	DET
admet-854	199	25	study	study	NOUN
admet-854	199	26	on	on	ADP
admet-854	199	27	the	the	DET
admet-854	199	28	hypothesis	hypothesis	NOUN
admet-854	199	29	of	of	ADP
admet-854	199	30	the	the	DET
admet-854	199	31	ak	ak	PROPN
admet-854	199	32	–	–	PUNCT
admet-854	199	33	amantadine	amantadine	NOUN
admet-854	199	34	–	–	PUNCT
admet-854	199	35	pd	pd	NOUN
admet-854	199	36	connection	connection	NOUN
admet-854	199	37	.	.	PUNCT
admet-854	200	1	among	among	ADP
admet-854	200	2	the	the	DET
admet-854	200	3	aks	ak	NOUN
admet-854	200	4	included	include	VERB
admet-854	200	5	in	in	ADP
admet-854	200	6	the	the	DET
admet-854	200	7	present	present	ADJ
admet-854	200	8	study	study	NOUN
admet-854	200	9	the	the	DET
admet-854	200	10	zebrafish	zebrafish	ADJ
admet-854	200	11	ak1	ak1	NOUN
admet-854	200	12	(	(	PUNCT
admet-854	200	13	pdb	pdb	PROPN
admet-854	200	14	i	i	PROPN
admet-854	200	15	d	d	PROPN
admet-854	200	16	5xz2	5xz2	NUM
admet-854	200	17	)	)	PUNCT
admet-854	200	18	,	,	PUNCT
admet-854	200	19	human	human	ADJ
admet-854	200	20	ak2	ak2	NOUN
admet-854	200	21	(	(	PUNCT
admet-854	200	22	pdb	pdb	PROPN
admet-854	200	23	i	i	PROPN
admet-854	200	24	d	d	PROPN
admet-854	200	25	2c9y	2c9y	PROPN
admet-854	200	26	)	)	PUNCT
admet-854	200	27	,	,	PUNCT
admet-854	200	28	human	human	ADJ
admet-854	200	29	ak5	ak5	NOUN
admet-854	200	30	(	(	PUNCT
admet-854	200	31	pdb	pdb	PROPN
admet-854	200	32	i	i	PROPN
admet-854	200	33	d	d	PROPN
admet-854	200	34	2bwj	2bwj	NUM
admet-854	200	35	)	)	PUNCT
admet-854	200	36	,	,	PUNCT
admet-854	200	37	and	and	CCONJ
admet-854	200	38	ak	ak	PROPN
admet-854	200	39	from	from	ADP
admet-854	200	40	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	200	41	(	(	PUNCT
admet-854	200	42	pdb	pdb	PROPN
admet-854	200	43	i	i	PROPN
admet-854	200	44	d	d	PROPN
admet-854	200	45	1zip	1zip	PROPN
admet-854	200	46	)	)	PUNCT
admet-854	200	47	show	show	VERB
admet-854	200	48	the	the	DET
admet-854	200	49	most	most	ADJ
admet-854	200	50	differences	difference	NOUN
admet-854	200	51	in	in	ADP
admet-854	200	52	interactions	interaction	NOUN
admet-854	200	53	with	with	ADP
admet-854	200	54	the	the	DET
admet-854	200	55	two	two	NUM
admet-854	200	56	forms	form	NOUN
admet-854	200	57	of	of	ADP
admet-854	200	58	amantadine	amantadine	NOUN
admet-854	200	59	(	(	PUNCT
admet-854	200	60	figure	figure	NOUN
admet-854	200	61	11	11	NUM
admet-854	200	62	)	)	PUNCT
admet-854	200	63	.	.	PUNCT
admet-854	201	1	multiple	multiple	ADJ
admet-854	201	2	sequence	sequence	NOUN
admet-854	201	3	alignment	alignment	NOUN
admet-854	201	4	of	of	ADP
admet-854	201	5	the	the	DET
admet-854	201	6	aks	ak	NOUN
admet-854	201	7	isoforms	isoform	VERB
admet-854	201	8	the	the	DET
admet-854	201	9	multiple	multiple	ADJ
admet-854	201	10	sequence	sequence	NOUN
admet-854	201	11	alignment	alignment	NOUN
admet-854	201	12	allows	allow	VERB
admet-854	201	13	an	an	DET
admet-854	201	14	overview	overview	NOUN
admet-854	201	15	of	of	ADP
admet-854	201	16	the	the	DET
admet-854	201	17	interactions	interaction	NOUN
admet-854	201	18	of	of	ADP
admet-854	201	19	the	the	DET
admet-854	201	20	two	two	NUM
admet-854	201	21	forms	form	NOUN
admet-854	201	22	of	of	ADP
admet-854	201	23	amantadine	amantadine	NOUN
admet-854	201	24	with	with	ADP
admet-854	201	25	the	the	DET
admet-854	201	26	aks	ak	NOUN
admet-854	201	27	isoforms	isoform	NOUN
admet-854	201	28	.	.	PUNCT
admet-854	202	1	the	the	DET
admet-854	202	2	residues	residue	NOUN
admet-854	202	3	involved	involve	VERB
admet-854	202	4	substrate	substrate	NOUN
admet-854	202	5	binding	bind	VERB
admet-854	202	6	are	be	AUX
admet-854	202	7	well	well	ADV
admet-854	202	8	conserved	conserve	VERB
admet-854	202	9	among	among	ADP
admet-854	202	10	bacterial	bacterial	ADJ
admet-854	202	11	aks	ak	NOUN
admet-854	202	12	and	and	CCONJ
admet-854	202	13	eucaryotes	eucaryote	VERB
admet-854	202	14	aks	ak	NOUN
admet-854	202	15	.	.	PUNCT
admet-854	203	1	the	the	DET
admet-854	203	2	interaction	interaction	NOUN
admet-854	203	3	of	of	ADP
admet-854	203	4	unionized	unionized	ADJ
admet-854	203	5	amantadine	amantadine	NOUN
admet-854	203	6	with	with	ADP
admet-854	203	7	zebrafish	zebrafish	ADJ
admet-854	203	8	ak1	ak1	NOUN
admet-854	203	9	and	and	CCONJ
admet-854	203	10	human	human	ADJ
admet-854	203	11	ak4	ak4	NOUN
admet-854	203	12	mainly	mainly	ADV
admet-854	203	13	involves	involve	VERB
admet-854	203	14	the	the	DET
admet-854	203	15	residues	residue	NOUN
admet-854	203	16	from	from	ADP
admet-854	203	17	the	the	DET
admet-854	203	18	lid	lid	NOUN
admet-854	203	19	region	region	NOUN
admet-854	203	20	that	that	PRON
admet-854	203	21	interact	interact	VERB
admet-854	203	22	with	with	ADP
admet-854	203	23	unionized	unionized	ADJ
admet-854	203	24	amantadine	amantadine	NOUN
admet-854	203	25	.	.	PUNCT
admet-854	204	1	in	in	ADP
admet-854	204	2	contrast	contrast	NOUN
admet-854	204	3	,	,	PUNCT
admet-854	204	4	the	the	DET
admet-854	204	5	human	human	PROPN
admet-854	204	6	ak1	ak1	PROPN
admet-854	204	7	,	,	PUNCT
admet-854	204	8	and	and	CCONJ
admet-854	204	9	ak5	ak5	VERB
admet-854	204	10	interact	interact	VERB
admet-854	204	11	with	with	ADP
admet-854	204	12	unionized	unionize	VERB
admet-854	204	13	amantadine	amantadine	NOUN
admet-854	204	14	through	through	ADP
admet-854	204	15	amp	amp	NOUN
admet-854	204	16	binding	bind	VERB
admet-854	204	17	residues	residue	NOUN
admet-854	204	18	.	.	PUNCT
admet-854	205	1	minor	minor	ADJ
admet-854	205	2	similarities	similarity	NOUN
admet-854	205	3	are	be	AUX
admet-854	205	4	noticed	notice	VERB
admet-854	205	5	between	between	ADP
admet-854	205	6	human	human	ADJ
admet-854	205	7	ak2	ak2	NOUN
admet-854	205	8	and	and	CCONJ
admet-854	205	9	ak	ak	PROPN
admet-854	205	10	from	from	ADP
admet-854	205	11	e.coli	e.coli	NOUN
admet-854	205	12	,	,	PUNCT
admet-854	205	13	both	both	PRON
admet-854	205	14	of	of	ADP
admet-854	205	15	which	which	PRON
admet-854	205	16	have	have	VERB
admet-854	205	17	two	two	NUM
admet-854	205	18	residues	residue	NOUN
admet-854	205	19	in	in	ADP
admet-854	205	20	the	the	DET
admet-854	205	21	phosphate	phosphate	NOUN
admet-854	205	22	-	-	PUNCT
admet-854	205	23	binding	bind	VERB
admet-854	205	24	loop	loop	NOUN
admet-854	205	25	(	(	PUNCT
admet-854	205	26	p	p	NOUN
admet-854	205	27	-	-	PUNCT
admet-854	205	28	loop	loop	NOUN
admet-854	205	29	)	)	PUNCT
admet-854	205	30	that	that	PRON
admet-854	205	31	interact	interact	VERB
admet-854	205	32	with	with	ADP
admet-854	205	33	unionized	unionized	ADJ
admet-854	205	34	amantadine	amantadine	NOUN
admet-854	205	35	–	–	PUNCT
admet-854	205	36	one	one	NUM
admet-854	205	37	residue	residue	NOUN
admet-854	205	38	glycine	glycine	NOUN
admet-854	205	39	being	be	AUX
admet-854	205	40	identical	identical	ADJ
admet-854	205	41	for	for	ADP
admet-854	205	42	the	the	DET
admet-854	205	43	two	two	NUM
admet-854	205	44	enzymes	enzyme	NOUN
admet-854	205	45	.	.	PUNCT
admet-854	206	1	also	also	ADV
admet-854	206	2	,	,	PUNCT
admet-854	206	3	human	human	PROPN
admet-854	206	4	ak1	ak1	PROPN
admet-854	206	5	shows	show	VERB
admet-854	206	6	some	some	DET
admet-854	206	7	similarities	similarity	NOUN
admet-854	206	8	with	with	ADP
admet-854	206	9	human	human	ADJ
admet-854	206	10	ak4	ak4	NOUN
admet-854	206	11	with	with	ADP
admet-854	206	12	three	three	NUM
admet-854	206	13	different	different	ADJ
admet-854	206	14	residues	residue	NOUN
admet-854	206	15	from	from	ADP
admet-854	206	16	the	the	DET
admet-854	206	17	lid	lid	NOUN
admet-854	206	18	region	region	NOUN
admet-854	206	19	.	.	PUNCT
admet-854	207	1	an	an	DET
admet-854	207	2	in	in	ADP
admet-854	207	3	-	-	PUNCT
admet-854	207	4	depth	depth	NOUN
admet-854	207	5	analysis	analysis	NOUN
admet-854	207	6	of	of	ADP
admet-854	207	7	the	the	DET
admet-854	207	8	two	two	NUM
admet-854	207	9	forms	form	NOUN
admet-854	207	10	of	of	ADP
admet-854	207	11	ionized	ionize	VERB
admet-854	207	12	amantadine	amantadine	NOUN
admet-854	207	13	shows	show	VERB
admet-854	207	14	that	that	SCONJ
admet-854	207	15	,	,	PUNCT
admet-854	207	16	except	except	SCONJ
admet-854	207	17	for	for	ADP
admet-854	207	18	ak5	ak5	NOUN
admet-854	207	19	(	(	PUNCT
admet-854	207	20	pdb	pdb	PROPN
admet-854	207	21	i	i	PROPN
admet-854	207	22	d	d	PROPN
admet-854	207	23	2bwj	2bwj	NUM
admet-854	207	24	)	)	PUNCT
admet-854	207	25	,	,	PUNCT
admet-854	207	26	the	the	DET
admet-854	207	27	ionized	ionized	ADJ
admet-854	207	28	amantadine	amantadine	NOUN
admet-854	207	29	interacts	interact	VERB
admet-854	207	30	predominantly	predominantly	ADV
admet-854	207	31	with	with	ADP
admet-854	207	32	amp	amp	NOUN
admet-854	207	33	binding	bind	VERB
admet-854	207	34	residues	residue	NOUN
admet-854	207	35	.	.	PUNCT
admet-854	208	1	among	among	ADP
admet-854	208	2	ak1	ak1	ADJ
admet-854	208	3	isoforms	isoform	NOUN
admet-854	208	4	,	,	PUNCT
admet-854	208	5	the	the	DET
admet-854	208	6	interactions	interaction	NOUN
admet-854	208	7	with	with	ADP
admet-854	208	8	ionized	ionized	ADJ
admet-854	208	9	amantadine	amantadine	NOUN
admet-854	208	10	are	be	AUX
admet-854	208	11	not	not	PART
admet-854	208	12	similar	similar	ADJ
admet-854	208	13	.	.	PUNCT
admet-854	209	1	the	the	DET
admet-854	209	2	ak2	ak2	NOUN
admet-854	209	3	(	(	PUNCT
admet-854	209	4	pdb	pdb	PROPN
admet-854	209	5	i	i	PROPN
admet-854	209	6	d	d	PROPN
admet-854	209	7	2c9y	2c9y	PROPN
admet-854	209	8	)	)	PUNCT
admet-854	209	9	and	and	CCONJ
admet-854	209	10	the	the	DET
admet-854	209	11	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	209	12	ak	ak	PROPN
admet-854	209	13	(	(	PUNCT
admet-854	209	14	pdb	pdb	PROPN
admet-854	209	15	i	i	PROPN
admet-854	209	16	d	d	PROPN
admet-854	209	17	1zip	1zip	PROPN
admet-854	209	18	)	)	PUNCT
admet-854	209	19	show	show	VERB
admet-854	209	20	a	a	DET
admet-854	209	21	better	well	ADJ
admet-854	209	22	match	match	NOUN
admet-854	209	23	with	with	ADP
admet-854	209	24	the	the	DET
admet-854	209	25	residues	residue	NOUN
admet-854	209	26	at	at	ADP
admet-854	209	27	the	the	DET
admet-854	209	28	catalytic	catalytic	ADJ
admet-854	209	29	site	site	NOUN
admet-854	209	30	with	with	ADP
admet-854	209	31	the	the	DET
admet-854	209	32	ionized	ionize	VERB
admet-854	209	33	amantadine	amantadine	NOUN
admet-854	209	34	.	.	PUNCT
admet-854	210	1	unlike	unlike	ADP
admet-854	210	2	unionized	unionized	ADJ
admet-854	210	3	amantadine	amantadine	NOUN
admet-854	210	4	,	,	PUNCT
admet-854	210	5	the	the	DET
admet-854	210	6	ionized	ionized	ADJ
admet-854	210	7	amantadine	amantadine	NOUN
admet-854	210	8	interacts	interact	VERB
admet-854	210	9	with	with	ADP
admet-854	210	10	more	more	ADJ
admet-854	210	11	amp	amp	NOUN
admet-854	210	12	binding	bind	VERB
admet-854	210	13	residues	residue	NOUN
admet-854	210	14	of	of	ADP
admet-854	210	15	ak1	ak1	NOUN
admet-854	210	16	and	and	CCONJ
admet-854	210	17	ak2	ak2	NOUN
admet-854	210	18	isoforms	isoform	NOUN
admet-854	210	19	(	(	PUNCT
admet-854	210	20	figure	figure	NOUN
admet-854	210	21	12	12	NUM
admet-854	210	22	)	)	PUNCT
admet-854	210	23	.	.	PUNCT
admet-854	211	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	211	2	mihaela	mihaela	PROPN
admet-854	211	3	ileana	ileana	PROPN
admet-854	211	4	ionescu	ionescu	PROPN
admet-854	211	5	admet	admet	PROPN
admet-854	211	6	&	&	CCONJ
admet-854	211	7	dmpk	dmpk	PROPN
admet-854	211	8	8(2	8(2	NUM
admet-854	211	9	)	)	PUNCT
admet-854	211	10	(	(	PUNCT
admet-854	211	11	2020	2020	NUM
admet-854	211	12	)	)	PUNCT
admet-854	211	13	149	149	NUM
admet-854	211	14	-	-	SYM
admet-854	211	15	175	175	NUM
admet-854	211	16	160	160	NUM
admet-854	211	17	(	(	PUNCT
admet-854	211	18	a	a	NOUN
admet-854	211	19	)	)	PUNCT
admet-854	211	20	(	(	PUNCT
admet-854	211	21	b	b	X
admet-854	211	22	)	)	PUNCT
admet-854	211	23	(	(	PUNCT
admet-854	211	24	c	c	X
admet-854	211	25	)	)	PUNCT
admet-854	211	26	(	(	PUNCT
admet-854	211	27	d	d	X
admet-854	211	28	)	)	PUNCT
admet-854	211	29	(	(	PUNCT
admet-854	211	30	e	e	NOUN
admet-854	211	31	)	)	PUNCT
admet-854	211	32	(	(	PUNCT
admet-854	211	33	f	f	X
admet-854	211	34	)	)	PUNCT
admet-854	211	35	(	(	PUNCT
admet-854	211	36	g	g	NOUN
admet-854	211	37	)	)	PUNCT
admet-854	211	38	figure	figure	NOUN
admet-854	211	39	11	11	NUM
admet-854	211	40	.	.	PUNCT
admet-854	211	41	interactions	interaction	NOUN
admet-854	211	42	of	of	ADP
admet-854	211	43	unionized	unionized	ADJ
admet-854	211	44	and	and	CCONJ
admet-854	211	45	ionized	ionized	ADJ
admet-854	211	46	amantadine	amantadine	NOUN
admet-854	211	47	with	with	ADP
admet-854	211	48	aks	ak	NOUN
admet-854	211	49	.	.	PUNCT
admet-854	212	1	(	(	PUNCT
admet-854	212	2	a	a	X
admet-854	212	3	)	)	PUNCT
admet-854	212	4	human	human	ADJ
admet-854	212	5	ak1	ak1	PROPN
admet-854	212	6	(	(	PUNCT
admet-854	212	7	pdb	pdb	PROPN
admet-854	212	8	i	i	NOUN
admet-854	212	9	d	d	PROPN
admet-854	212	10	2c95	2c95	ADV
admet-854	212	11	)	)	PUNCT
admet-854	212	12	;	;	PUNCT
admet-854	212	13	(	(	PUNCT
admet-854	212	14	b	b	X
admet-854	212	15	)	)	PUNCT
admet-854	212	16	human	human	ADJ
admet-854	212	17	ak1	ak1	PROPN
admet-854	212	18	(	(	PUNCT
admet-854	212	19	pdb	pdb	PROPN
admet-854	212	20	i	i	PROPN
admet-854	212	21	d	d	PROPN
admet-854	212	22	1z85	1z85	NUM
admet-854	212	23	)	)	PUNCT
admet-854	212	24	(	(	PUNCT
admet-854	212	25	c	c	X
admet-854	212	26	)	)	PUNCT
admet-854	212	27	zebrafish	zebrafish	PROPN
admet-854	212	28	ak1	ak1	NOUN
admet-854	212	29	(	(	PUNCT
admet-854	212	30	pdb	pdb	PROPN
admet-854	212	31	i	i	PROPN
admet-854	212	32	d	d	PROPN
admet-854	212	33	5xz2	5xz2	NUM
admet-854	212	34	)	)	PUNCT
admet-854	212	35	;	;	PUNCT
admet-854	212	36	(	(	PUNCT
admet-854	212	37	d	d	X
admet-854	212	38	)	)	PUNCT
admet-854	212	39	human	human	ADJ
admet-854	212	40	ak2	ak2	NOUN
admet-854	212	41	(	(	PUNCT
admet-854	212	42	pdb	pdb	PROPN
admet-854	212	43	i	i	PROPN
admet-854	212	44	d	d	PROPN
admet-854	212	45	2c9y	2c9y	PROPN
admet-854	212	46	)	)	PUNCT
admet-854	212	47	;	;	PUNCT
admet-854	212	48	(	(	PUNCT
admet-854	212	49	e	e	X
admet-854	212	50	)	)	PUNCT
admet-854	212	51	human	human	ADJ
admet-854	212	52	ak5	ak5	NOUN
admet-854	212	53	(	(	PUNCT
admet-854	212	54	pdb	pdb	PROPN
admet-854	212	55	i	i	PROPN
admet-854	212	56	d	d	PROPN
admet-854	212	57	2bwj	2bwj	NUM
admet-854	212	58	)	)	PUNCT
admet-854	212	59	(	(	PUNCT
admet-854	212	60	f	f	X
admet-854	212	61	)	)	PUNCT
admet-854	212	62	ak	ak	PROPN
admet-854	212	63	from	from	ADP
admet-854	212	64	e.coli	e.coli	NOUN
admet-854	212	65	(	(	PUNCT
admet-854	212	66	pdb	pdb	PROPN
admet-854	212	67	i	i	PROPN
admet-854	212	68	d	d	PROPN
admet-854	212	69	3hpq	3hpq	PROPN
admet-854	212	70	)	)	PUNCT
admet-854	212	71	;	;	PUNCT
admet-854	212	72	(	(	PUNCT
admet-854	212	73	g	g	NOUN
admet-854	212	74	)	)	PUNCT
admet-854	212	75	ak	ak	PROPN
admet-854	212	76	from	from	ADP
admet-854	212	77	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	212	78	(	(	PUNCT
admet-854	212	79	pdb	pdb	PROPN
admet-854	212	80	i	i	PROPN
admet-854	212	81	d	d	PROPN
admet-854	212	82	1zip	1zip	NUM
admet-854	212	83	)	)	PUNCT
admet-854	212	84	;	;	PUNCT
admet-854	212	85	unionized	unionize	VERB
admet-854	212	86	amantadine	amantadine	NOUN
admet-854	212	87	is	be	AUX
admet-854	212	88	shown	show	VERB
admet-854	212	89	in	in	ADP
admet-854	212	90	yellow	yellow	ADJ
admet-854	212	91	.	.	PUNCT
admet-854	213	1	admet	admet	PROPN
admet-854	213	2	&	&	CCONJ
admet-854	213	3	dmpk	dmpk	PROPN
admet-854	213	4	8(2	8(2	NUM
admet-854	213	5	)	)	PUNCT
admet-854	213	6	(	(	PUNCT
admet-854	213	7	2020	2020	NUM
admet-854	213	8	)	)	PUNCT
admet-854	213	9	149	149	NUM
admet-854	213	10	-	-	SYM
admet-854	213	11	175	175	NUM
admet-854	213	12	amantadine	amantadine	NOUN
admet-854	213	13	binding	bind	VERB
admet-854	213	14	to	to	ADP
admet-854	213	15	the	the	DET
admet-854	213	16	enzymes	enzyme	NOUN
admet-854	213	17	regulated	regulate	VERB
admet-854	213	18	in	in	ADP
admet-854	213	19	parkinson	parkinson	NOUN
admet-854	213	20	’s	’s	PART
admet-854	213	21	disease	disease	NOUN
admet-854	213	22	doi	doi	NOUN
admet-854	213	23	:	:	PUNCT
admet-854	213	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	213	25	161	161	NUM
admet-854	213	26	figure	figure	NOUN
admet-854	213	27	12	12	NUM
admet-854	213	28	.	.	PUNCT
admet-854	214	1	multiple	multiple	ADJ
admet-854	214	2	sequence	sequence	NOUN
admet-854	214	3	alignment	alignment	NOUN
admet-854	214	4	of	of	ADP
admet-854	214	5	the	the	DET
admet-854	214	6	aks	ak	NOUN
admet-854	214	7	sequences	sequence	NOUN
admet-854	214	8	.	.	PUNCT
admet-854	215	1	in	in	ADP
admet-854	215	2	gray	gray	ADJ
admet-854	215	3	background	background	NOUN
admet-854	215	4	are	be	AUX
admet-854	215	5	marked	mark	VERB
admet-854	215	6	the	the	DET
admet-854	215	7	residues	residue	NOUN
admet-854	215	8	belong	belong	VERB
admet-854	215	9	to	to	ADP
admet-854	215	10	walker	walker	NOUN
admet-854	215	11	a	a	DET
admet-854	215	12	motif	motif	NOUN
admet-854	215	13	–	–	PUNCT
admet-854	215	14	phosphate	phosphate	NOUN
admet-854	215	15	-	-	PUNCT
admet-854	215	16	binding	bind	VERB
admet-854	215	17	loop	loop	NOUN
admet-854	215	18	or	or	CCONJ
admet-854	215	19	p	p	NOUN
admet-854	215	20	-	-	PUNCT
admet-854	215	21	loop	loop	NOUN
admet-854	215	22	;	;	PUNCT
admet-854	215	23	in	in	ADP
admet-854	215	24	yellow	yellow	ADJ
admet-854	215	25	background	background	NOUN
admet-854	215	26	is	be	AUX
admet-854	215	27	marked	mark	VERB
admet-854	215	28	the	the	DET
admet-854	215	29	nmp	nmp	NOUN
admet-854	215	30	binding	bind	VERB
admet-854	215	31	region	region	NOUN
admet-854	215	32	and	and	CCONJ
admet-854	215	33	the	the	DET
admet-854	215	34	residues	residue	NOUN
admet-854	215	35	that	that	PRON
admet-854	215	36	belong	belong	VERB
admet-854	215	37	to	to	ADP
admet-854	215	38	amp	amp	NOUN
admet-854	215	39	binding	bind	VERB
admet-854	215	40	region	region	NOUN
admet-854	215	41	are	be	AUX
admet-854	215	42	italic	italic	ADV
admet-854	215	43	-	-	PUNCT
admet-854	215	44	bolded	bolde	VERB
admet-854	215	45	;	;	PUNCT
admet-854	215	46	in	in	ADP
admet-854	215	47	blue	blue	ADJ
admet-854	215	48	background	background	NOUN
admet-854	215	49	is	be	AUX
admet-854	215	50	marked	mark	VERB
admet-854	215	51	the	the	DET
admet-854	215	52	lid	lid	NOUN
admet-854	215	53	region	region	NOUN
admet-854	215	54	;	;	PUNCT
admet-854	215	55	with	with	ADP
admet-854	215	56	red	red	NOUN
admet-854	215	57	are	be	AUX
admet-854	215	58	marked	mark	VERB
admet-854	215	59	the	the	DET
admet-854	215	60	residues	residue	NOUN
admet-854	215	61	(	(	PUNCT
admet-854	215	62	van	van	NOUN
admet-854	215	63	der	der	NOUN
admet-854	215	64	waals	waal	NOUN
admet-854	215	65	,	,	PUNCT
admet-854	215	66	conventional	conventional	ADJ
admet-854	215	67	hydrogen	hydrogen	NOUN
admet-854	215	68	bond	bond	NOUN
admet-854	215	69	or	or	CCONJ
admet-854	215	70	alkyl	alkyl	ADJ
admet-854	215	71	interactions	interaction	NOUN
admet-854	215	72	)	)	PUNCT
admet-854	215	73	which	which	PRON
admet-854	215	74	interact	interact	VERB
admet-854	215	75	with	with	ADP
admet-854	215	76	amantadine	amantadine	ADJ
admet-854	215	77	ionized	ionize	VERB
admet-854	215	78	form	form	NOUN
admet-854	215	79	(	(	PUNCT
admet-854	215	80	with	with	ADP
admet-854	215	81	–	–	PUNCT
admet-854	215	82	nh3	nh3	NOUN
admet-854	215	83	+	+	NUM
admet-854	215	84	group	group	NOUN
admet-854	215	85	)	)	PUNCT
admet-854	215	86	;	;	PUNCT
admet-854	215	87	the	the	DET
admet-854	215	88	residues	residue	NOUN
admet-854	215	89	which	which	PRON
admet-854	215	90	interact	interact	VERB
admet-854	215	91	with	with	ADP
admet-854	215	92	amantadine	amantadine	NOUN
admet-854	215	93	unionized	unionize	VERB
admet-854	215	94	form	form	NOUN
admet-854	215	95	(	(	PUNCT
admet-854	215	96	with	with	ADP
admet-854	215	97	–	–	PUNCT
admet-854	215	98	nh2	nh2	NOUN
admet-854	215	99	group	group	NOUN
admet-854	215	100	)	)	PUNCT
admet-854	215	101	are	be	AUX
admet-854	215	102	bolded	bolde	VERB
admet-854	215	103	-	-	PUNCT
admet-854	215	104	underlined	underline	VERB
admet-854	215	105	;	;	PUNCT
admet-854	215	106	the	the	DET
admet-854	215	107	residues	residue	NOUN
admet-854	215	108	which	which	PRON
admet-854	215	109	interact	interact	VERB
admet-854	215	110	with	with	ADP
admet-854	215	111	amantadine	amantadine	NOUN
admet-854	215	112	unionized	unionize	VERB
admet-854	215	113	and	and	CCONJ
admet-854	215	114	ionized	ionized	ADJ
admet-854	215	115	are	be	AUX
admet-854	215	116	red	red	ADJ
admet-854	215	117	and	and	CCONJ
admet-854	215	118	bolded	bolde	VERB
admet-854	215	119	-	-	PUNCT
admet-854	215	120	underlined	underlined	ADJ
admet-854	215	121	;	;	PUNCT
admet-854	215	122	akec	akec	NOUN
admet-854	215	123	is	be	AUX
admet-854	215	124	ak	ak	PROPN
admet-854	215	125	from	from	ADP
admet-854	215	126	e.coli	e.coli	NOUN
admet-854	215	127	;	;	PUNCT
admet-854	215	128	akbs	akbs	PROPN
admet-854	215	129	is	be	AUX
admet-854	215	130	ak	ak	PROPN
admet-854	215	131	from	from	ADP
admet-854	215	132	b.stearothermophilus	b.stearothermophilus	ADJ
admet-854	215	133	;	;	PUNCT
admet-854	215	134	with	with	ADP
admet-854	215	135	dot	dot	NOUN
admet-854	215	136	“	"	PUNCT
admet-854	215	137	.	.	PUNCT
admet-854	215	138	”	"	PUNCT
admet-854	215	139	are	be	AUX
admet-854	215	140	marked	mark	VERB
admet-854	215	141	the	the	DET
admet-854	215	142	semi	semi	ADJ
admet-854	215	143	-	-	ADJ
admet-854	215	144	conservative	conservative	ADJ
admet-854	215	145	replacements	replacement	NOUN
admet-854	215	146	;	;	PUNCT
admet-854	215	147	with	with	ADP
admet-854	215	148	colon	colon	NOUN
admet-854	215	149	“	"	PUNCT
admet-854	215	150	:	:	PUNCT
admet-854	215	151	”	"	PUNCT
admet-854	215	152	are	be	AUX
admet-854	215	153	marked	mark	VERB
admet-854	215	154	the	the	DET
admet-854	215	155	conservative	conservative	ADJ
admet-854	215	156	replacements	replacement	NOUN
admet-854	215	157	;	;	PUNCT
admet-854	215	158	with	with	ADP
admet-854	215	159	“	"	PUNCT
admet-854	215	160	*	*	NOUN
admet-854	215	161	”	"	PUNCT
admet-854	215	162	are	be	AUX
admet-854	215	163	marked	mark	VERB
admet-854	215	164	the	the	DET
admet-854	215	165	identities	identity	NOUN
admet-854	215	166	of	of	ADP
admet-854	215	167	the	the	DET
admet-854	215	168	residues	residue	NOUN
admet-854	215	169	.	.	PUNCT
admet-854	216	1	molecular	molecular	ADJ
admet-854	216	2	docking	docking	NOUN
admet-854	216	3	of	of	ADP
admet-854	216	4	the	the	DET
admet-854	216	5	human	human	ADJ
admet-854	216	6	adenine	adenine	NOUN
admet-854	216	7	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	216	8	with	with	ADP
admet-854	216	9	ionized	ionized	ADJ
admet-854	216	10	amantadine	amantadine	NOUN
admet-854	216	11	and	and	CCONJ
admet-854	216	12	the	the	DET
admet-854	216	13	redocking	redocking	NOUN
admet-854	216	14	with	with	ADP
admet-854	216	15	the	the	DET
admet-854	216	16	substrates	substrate	NOUN
admet-854	216	17	the	the	DET
admet-854	216	18	human	human	ADJ
admet-854	216	19	aprts	aprt	NOUN
admet-854	216	20	(	(	PUNCT
admet-854	216	21	e.c	e.c	PROPN
admet-854	216	22	.	.	PROPN
admet-854	216	23	2.4.2.7	2.4.2.7	NUM
admet-854	216	24	)	)	PUNCT
admet-854	216	25	found	find	VERB
admet-854	216	26	in	in	ADP
admet-854	216	27	pdb	pdb	PROPN
admet-854	216	28	were	be	AUX
admet-854	216	29	analyzed	analyze	VERB
admet-854	216	30	for	for	ADP
admet-854	216	31	the	the	DET
admet-854	216	32	amantadine	amantadine	NOUN
admet-854	216	33	interactions	interaction	NOUN
admet-854	216	34	.	.	PUNCT
admet-854	217	1	the	the	DET
admet-854	217	2	enzyme	enzyme	NOUN
admet-854	217	3	catalyses	catalyse	VERB
admet-854	217	4	the	the	DET
admet-854	217	5	reaction	reaction	NOUN
admet-854	217	6	:	:	PUNCT
admet-854	217	7	amp	amp	PROPN
admet-854	217	8	+	+	CCONJ
admet-854	217	9	diphosphate	diphosphate	ADJ
admet-854	217	10	=	=	SYM
admet-854	217	11	5	5	NUM
admet-854	217	12	-	-	PUNCT
admet-854	217	13	phospho	phospho	ADJ
admet-854	217	14	-	-	PUNCT
admet-854	217	15	alpha	alpha	NOUN
admet-854	217	16	-	-	PUNCT
admet-854	217	17	d	d	NOUN
admet-854	217	18	-	-	PUNCT
admet-854	217	19	ribose	ribose	ADJ
admet-854	217	20	1	1	NUM
admet-854	217	21	-	-	PUNCT
admet-854	217	22	diphosphate	diphosphate	ADJ
admet-854	217	23	+	+	CCONJ
admet-854	217	24	adenine	adenine	NOUN
admet-854	217	25	.	.	PUNCT
admet-854	218	1	in	in	ADP
admet-854	218	2	the	the	DET
admet-854	218	3	adenine	adenine	ADJ
admet-854	218	4	metabolism	metabolism	NOUN
admet-854	218	5	,	,	PUNCT
admet-854	218	6	aprt	aprt	PROPN
admet-854	218	7	is	be	AUX
admet-854	218	8	involved	involve	VERB
admet-854	218	9	in	in	ADP
admet-854	218	10	the	the	DET
admet-854	218	11	first	first	ADJ
admet-854	218	12	stage	stage	NOUN
admet-854	218	13	of	of	ADP
admet-854	218	14	the	the	DET
admet-854	218	15	subpathway	subpathway	NOUN
admet-854	218	16	that	that	PRON
admet-854	218	17	synthesizes	synthesize	VERB
admet-854	218	18	amp	amp	NOUN
admet-854	218	19	from	from	ADP
admet-854	218	20	adenine	adenine	NOUN
admet-854	218	21	(	(	PUNCT
admet-854	218	22	uniprotkb	uniprotkb	NOUN
admet-854	218	23	p07741	p07741	PROPN
admet-854	218	24	)	)	PUNCT
admet-854	218	25	.	.	PUNCT
admet-854	219	1	thus	thus	ADV
admet-854	219	2	,	,	PUNCT
admet-854	219	3	in	in	ADP
admet-854	219	4	adenine	adenine	ADJ
admet-854	219	5	metabolism	metabolism	NOUN
admet-854	219	6	,	,	PUNCT
admet-854	219	7	aprt	aprt	PROPN
admet-854	219	8	is	be	AUX
admet-854	219	9	closely	closely	ADV
admet-854	219	10	connected	connect	VERB
admet-854	219	11	with	with	ADP
admet-854	219	12	ak	ak	PROPN
admet-854	219	13	by	by	ADP
admet-854	219	14	the	the	DET
admet-854	219	15	substrate	substrate	NOUN
admet-854	219	16	amp	amp	NOUN
admet-854	219	17	.	.	PUNCT
admet-854	220	1	therefore	therefore	ADV
admet-854	220	2	,	,	PUNCT
admet-854	220	3	the	the	DET
admet-854	220	4	aprt	aprt	NOUN
admet-854	220	5	was	be	AUX
admet-854	220	6	the	the	DET
admet-854	220	7	first	first	ADJ
admet-854	220	8	enzyme	enzyme	NOUN
admet-854	220	9	tested	test	VERB
admet-854	220	10	to	to	PART
admet-854	220	11	verify	verify	VERB
admet-854	220	12	the	the	DET
admet-854	220	13	hypothesis	hypothesis	NOUN
admet-854	220	14	that	that	PRON
admet-854	220	15	amantadine	amantadine	NOUN
admet-854	220	16	specifically	specifically	ADV
admet-854	220	17	binds	bind	VERB
admet-854	220	18	some	some	DET
admet-854	220	19	human	human	ADJ
admet-854	220	20	aks	ak	NOUN
admet-854	220	21	isoforms	isoform	NOUN
admet-854	220	22	.	.	PUNCT
admet-854	221	1	first	first	ADV
admet-854	221	2	,	,	PUNCT
admet-854	221	3	the	the	DET
admet-854	221	4	redock	redock	NOUN
admet-854	221	5	of	of	ADP
admet-854	221	6	the	the	DET
admet-854	221	7	substrates	substrate	NOUN
admet-854	221	8	co	co	VERB
admet-854	221	9	-	-	VERB
admet-854	221	10	crystallized	crystallized	ADJ
admet-854	221	11	in	in	ADP
admet-854	221	12	the	the	DET
admet-854	221	13	x	x	NOUN
admet-854	221	14	-	-	NOUN
admet-854	221	15	ray	ray	ADJ
admet-854	221	16	3d	3d	PROPN
admet-854	221	17	structures	structure	NOUN
admet-854	221	18	was	be	AUX
admet-854	221	19	made	make	VERB
admet-854	221	20	.	.	PUNCT
admet-854	222	1	then	then	ADV
admet-854	222	2	,	,	PUNCT
admet-854	222	3	amantadine	amantadine	ADJ
admet-854	222	4	ionized	ionized	ADJ
admet-854	222	5	form	form	NOUN
admet-854	222	6	was	be	AUX
admet-854	222	7	tested	test	VERB
admet-854	222	8	and	and	CCONJ
admet-854	222	9	the	the	DET
admet-854	222	10	interactions	interaction	NOUN
admet-854	222	11	with	with	ADP
admet-854	222	12	the	the	DET
admet-854	222	13	residues	residue	NOUN
admet-854	222	14	from	from	ADP
admet-854	222	15	the	the	DET
admet-854	222	16	catalytic	catalytic	ADJ
admet-854	222	17	site	site	NOUN
admet-854	222	18	(	(	PUNCT
admet-854	222	19	table2	table2	PROPN
admet-854	222	20	)	)	PUNCT
admet-854	222	21	.	.	PUNCT
admet-854	223	1	among	among	ADP
admet-854	223	2	the	the	DET
admet-854	223	3	four	four	NUM
admet-854	223	4	pdb	pdb	NOUN
admet-854	223	5	structure	structure	NOUN
admet-854	223	6	co	co	VERB
admet-854	223	7	-	-	VERB
admet-854	223	8	crystallized	crystallize	VERB
admet-854	223	9	with	with	ADP
admet-854	223	10	adenosine	adenosine	ADJ
admet-854	223	11	monophosphate	monophosphate	NOUN
admet-854	223	12	(	(	PUNCT
admet-854	223	13	amp	amp	PROPN
admet-854	223	14	)	)	PUNCT
admet-854	223	15	(	(	PUNCT
admet-854	223	16	pdb	pdb	PROPN
admet-854	223	17	id(s	id(s	PUNCT
admet-854	223	18	)	)	PUNCT
admet-854	223	19	1ore	1ore	NUM
admet-854	223	20	,	,	PUNCT
admet-854	223	21	1zn8	1zn8	NUM
admet-854	223	22	,	,	PUNCT
admet-854	223	23	1zn9	1zn9	NUM
admet-854	223	24	,	,	PUNCT
admet-854	223	25	and	and	CCONJ
admet-854	223	26	4x44	4x44	NOUN
admet-854	223	27	)	)	PUNCT
admet-854	223	28	,	,	PUNCT
admet-854	223	29	two	two	NUM
admet-854	223	30	of	of	ADP
admet-854	223	31	them	they	PRON
admet-854	223	32	show	show	VERB
admet-854	223	33	the	the	DET
admet-854	223	34	best	good	ADJ
admet-854	223	35	interaction	interaction	NOUN
admet-854	223	36	of	of	ADP
admet-854	223	37	amantadine	amantadine	NOUN
admet-854	223	38	with	with	ADP
admet-854	223	39	the	the	DET
admet-854	223	40	amp	amp	NOUN
admet-854	223	41	-	-	PUNCT
admet-854	223	42	binding	bind	VERB
admet-854	223	43	residues	residue	NOUN
admet-854	223	44	.	.	PUNCT
admet-854	224	1	the	the	DET
admet-854	224	2	amantadine	amantadine	NOUN
admet-854	224	3	–	–	PUNCT
admet-854	224	4	1zn9	1zn9	NUM
admet-854	224	5	interactions	interaction	NOUN
admet-854	224	6	involve	involve	VERB
admet-854	224	7	four	four	NUM
admet-854	224	8	residues	residue	NOUN
admet-854	224	9	that	that	PRON
admet-854	224	10	also	also	ADV
admet-854	224	11	bind	bind	VERB
admet-854	224	12	amp	amp	NOUN
admet-854	224	13	(	(	PUNCT
admet-854	224	14	figure	figure	NOUN
admet-854	224	15	13	13	NUM
admet-854	224	16	)	)	PUNCT
admet-854	224	17	.	.	PUNCT
admet-854	225	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	225	2	mihaela	mihaela	PROPN
admet-854	225	3	ileana	ileana	PROPN
admet-854	225	4	ionescu	ionescu	PROPN
admet-854	225	5	admet	admet	PROPN
admet-854	225	6	&	&	CCONJ
admet-854	225	7	dmpk	dmpk	PROPN
admet-854	225	8	8(2	8(2	NUM
admet-854	225	9	)	)	PUNCT
admet-854	225	10	(	(	PUNCT
admet-854	225	11	2020	2020	NUM
admet-854	225	12	)	)	PUNCT
admet-854	225	13	149	149	NUM
admet-854	225	14	-	-	SYM
admet-854	225	15	175	175	NUM
admet-854	225	16	162	162	NUM
admet-854	225	17	table	table	NOUN
admet-854	225	18	2	2	NUM
admet-854	225	19	.	.	PUNCT
admet-854	226	1	the	the	DET
admet-854	226	2	energy	energy	NOUN
admet-854	226	3	binding	bind	VERB
admet-854	226	4	(	(	PUNCT
admet-854	226	5	δg	δg	VERB
admet-854	226	6	)	)	PUNCT
admet-854	226	7	and	and	CCONJ
admet-854	226	8	inhibition	inhibition	VERB
admet-854	226	9	constant	constant	ADJ
admet-854	226	10	(	(	PUNCT
admet-854	226	11	ki	ki	PROPN
admet-854	226	12	)	)	PUNCT
admet-854	226	13	of	of	ADP
admet-854	226	14	the	the	DET
admet-854	226	15	best	good	ADJ
admet-854	226	16	conformation	conformation	NOUN
admet-854	226	17	of	of	ADP
admet-854	226	18	the	the	DET
admet-854	226	19	complex	complex	ADJ
admet-854	226	20	aprt	aprt	NOUN
admet-854	226	21	amantadine	amantadine	NOUN
admet-854	226	22	(	(	PUNCT
admet-854	226	23	ionized	ionized	ADJ
admet-854	226	24	form	form	NOUN
admet-854	226	25	)	)	PUNCT
admet-854	226	26	and	and	CCONJ
admet-854	226	27	after	after	ADP
admet-854	226	28	redocking	redocke	VERB
admet-854	226	29	.	.	PUNCT
admet-854	227	1	pdb	pdb	PROPN
admet-854	228	1	i	i	NOUN
admet-854	228	2	d	d	PROPN
admet-854	228	3	amantadine	amantadine	NOUN
admet-854	228	4	redocking	redocke	VERB
admet-854	228	5	1	1	NUM
admet-854	228	6	δg	δg	PROPN
admet-854	228	7	(	(	PUNCT
admet-854	228	8	kcal	kcal	NOUN
admet-854	228	9	/	/	SYM
admet-854	228	10	mol	mol	NOUN
admet-854	228	11	)	)	PUNCT
admet-854	229	1	ki	ki	PROPN
admet-854	230	1	(	(	PUNCT
admet-854	230	2	μm	μm	INTJ
admet-854	230	3	)	)	PUNCT
admet-854	230	4	δg	δg	ADP
admet-854	230	5	(	(	PUNCT
admet-854	230	6	kcal	kcal	PROPN
admet-854	230	7	/	/	SYM
admet-854	230	8	mol	mol	NOUN
admet-854	230	9	)	)	PUNCT
admet-854	230	10	ki	ki	PROPN
admet-854	230	11	(	(	PUNCT
admet-854	230	12	μm	μm	NUM
admet-854	230	13	)	)	PUNCT
admet-854	230	14	1ore	1ore	NUM
admet-854	230	15	-6.44	-6.44	NUM
admet-854	230	16	18.93	18.93	NUM
admet-854	230	17	-6.91	-6.91	NUM
admet-854	230	18	8.68	8.68	NUM
admet-854	230	19	1zn9	1zn9	NUM
admet-854	230	20	-6.52	-6.52	ADJ
admet-854	230	21	16.77	16.77	NUM
admet-854	230	22	-6.3	-6.3	NUM
admet-854	230	23	24.04	24.04	NUM
admet-854	230	24	4x44	4x44	NOUN
admet-854	230	25	-6.01	-6.01	NUM
admet-854	230	26	39.53	39.53	NUM
admet-854	230	27	-8.1	-8.1	NUM
admet-854	230	28	1.15	1.15	NUM
admet-854	230	29	1zn8	1zn8	NUM
admet-854	230	30	-6.15	-6.15	NUM
admet-854	230	31	31.21	31.21	NUM
admet-854	230	32	-7.39	-7.39	NUM
admet-854	230	33	3.83	3.83	NUM
admet-854	230	34	6fci	6fci	NOUN
admet-854	230	35	-7.33	-7.33	NUM
admet-854	230	36	4.26	4.26	NUM
admet-854	230	37	-6.21	-6.21	NUM
admet-854	230	38	28.14	28.14	NUM
admet-854	230	39	1zn7	1zn7	NUM
admet-854	230	40	-6.9	-6.9	PROPN
admet-854	230	41	8.73	8.73	NUM
admet-854	230	42	-5.58	-5.58	NUM
admet-854	230	43	81.74	81.74	NUM
admet-854	230	44	1	1	NUM
admet-854	230	45	redocking	redocke	VERB
admet-854	230	46	with	with	ADP
admet-854	230	47	the	the	DET
admet-854	230	48	substrates	substrate	NOUN
admet-854	230	49	co	co	VERB
admet-854	230	50	-	-	VERB
admet-854	230	51	crystallized	crystallized	ADJ
admet-854	230	52	in	in	ADP
admet-854	230	53	pdb	pdb	PROPN
admet-854	230	54	x	x	PROPN
admet-854	230	55	-	-	NOUN
admet-854	230	56	ray	ray	NOUN
admet-854	230	57	3d	3d	PROPN
admet-854	230	58	structures	structure	NOUN
admet-854	230	59	.	.	PUNCT
admet-854	231	1	leu129	leu129	PROPN
admet-854	231	2	:o	:o	PROPN
admet-854	231	3	-	-	PUNCT
admet-854	231	4	h5	h5	PROPN
admet-854	231	5	3.06	3.06	NUM
admet-854	231	6	å	å	PROPN
admet-854	231	7	asp127	asp127	NOUN
admet-854	231	8	:	:	PUNCT
admet-854	231	9	od2	od2	NOUN
admet-854	231	10	-	-	PUNCT
admet-854	231	11	h28	h28	NOUN
admet-854	231	12	1.84	1.84	NUM
admet-854	231	13	å	å	PROPN
admet-854	231	14	asp128	asp128	NOUN
admet-854	231	15	:	:	PUNCT
admet-854	231	16	od1	od1	NOUN
admet-854	231	17	-	-	PUNCT
admet-854	231	18	h27	h27	NOUN
admet-854	231	19	2.04	2.04	NUM
admet-854	231	20	å	å	NOUN
admet-854	231	21	asp128	asp128	NOUN
admet-854	231	22	:	:	PUNCT
admet-854	231	23	od1	od1	NOUN
admet-854	231	24	-	-	PUNCT
admet-854	231	25	h5	h5	NOUN
admet-854	231	26	2.14	2.14	NUM
admet-854	231	27	å	å	PROPN
admet-854	231	28	ala131	ala131	PROPN
admet-854	231	29	4.03	4.03	NUM
admet-854	231	30	å	å	PROPN
admet-854	231	31	leu129	leu129	PROPN
admet-854	231	32	4.08	4.08	NUM
admet-854	231	33	å	å	PROPN
admet-854	231	34	(	(	PUNCT
admet-854	231	35	a	a	NOUN
admet-854	231	36	)	)	PUNCT
admet-854	231	37	(	(	PUNCT
admet-854	231	38	b	b	X
admet-854	231	39	)	)	PUNCT
admet-854	231	40	(	(	PUNCT
admet-854	231	41	c	c	X
admet-854	231	42	)	)	PUNCT
admet-854	231	43	figure	figure	NOUN
admet-854	231	44	13	13	NUM
admet-854	231	45	.	.	PUNCT
admet-854	231	46	interactions	interaction	NOUN
admet-854	231	47	of	of	ADP
admet-854	231	48	ionized	ionized	ADJ
admet-854	231	49	amantadine	amantadine	NOUN
admet-854	231	50	with	with	ADP
admet-854	231	51	aprt	aprt	PROPN
admet-854	231	52	co	co	VERB
admet-854	231	53	-	-	VERB
admet-854	231	54	crystallized	crystallize	VERB
admet-854	231	55	with	with	ADP
admet-854	231	56	amp	amp	PROPN
admet-854	231	57	,	,	PUNCT
admet-854	231	58	pdb	pdb	PROPN
admet-854	231	59	i	i	PROPN
admet-854	231	60	d	d	PROPN
admet-854	231	61	1zn9	1zn9	PROPN
admet-854	231	62	.	.	PUNCT
admet-854	232	1	(	(	PUNCT
admet-854	232	2	a	a	X
admet-854	232	3	)	)	PUNCT
admet-854	232	4	3d	3d	NUM
admet-854	232	5	display	display	NOUN
admet-854	232	6	of	of	ADP
admet-854	232	7	the	the	DET
admet-854	232	8	amantadine	amantadine	NOUN
admet-854	232	9	(	(	PUNCT
admet-854	232	10	shows	show	NOUN
admet-854	232	11	in	in	ADP
admet-854	232	12	yellow	yellow	ADJ
admet-854	232	13	)	)	PUNCT
admet-854	232	14	and	and	CCONJ
admet-854	232	15	amp	amp	NOUN
admet-854	232	16	in	in	ADP
admet-854	232	17	binding	bind	VERB
admet-854	232	18	pocket	pocket	NOUN
admet-854	232	19	;	;	PUNCT
admet-854	232	20	(	(	PUNCT
admet-854	232	21	b	b	X
admet-854	232	22	)	)	PUNCT
admet-854	232	23	code	code	NOUN
admet-854	232	24	color	color	NOUN
admet-854	232	25	for	for	ADP
admet-854	232	26	interactions	interaction	NOUN
admet-854	232	27	:	:	PUNCT
admet-854	232	28	in	in	ADP
admet-854	232	29	green	green	NOUN
admet-854	232	30	are	be	AUX
admet-854	232	31	shown	show	VERB
admet-854	232	32	conventional	conventional	ADJ
admet-854	232	33	hydrogen	hydrogen	NOUN
admet-854	232	34	bonds	bond	NOUN
admet-854	232	35	,	,	PUNCT
admet-854	232	36	orange	orange	ADJ
admet-854	232	37	–	–	PUNCT
admet-854	232	38	salt	salt	NOUN
admet-854	232	39	bridge	bridge	NOUN
admet-854	232	40	,	,	PUNCT
admet-854	232	41	mauve	mauve	NOUN
admet-854	232	42	–	–	PUNCT
admet-854	232	43	alkyl	alkyl	ADJ
admet-854	232	44	hydrophobic	hydrophobic	NOUN
admet-854	232	45	interactions	interaction	NOUN
admet-854	232	46	;	;	PUNCT
admet-854	232	47	(	(	PUNCT
admet-854	232	48	c	c	X
admet-854	232	49	)	)	PUNCT
admet-854	232	50	the	the	DET
admet-854	232	51	distances	distance	NOUN
admet-854	232	52	(	(	PUNCT
admet-854	232	53	å	å	NOUN
admet-854	232	54	)	)	PUNCT
admet-854	232	55	of	of	ADP
admet-854	232	56	the	the	DET
admet-854	232	57	1zn9	1zn9	NUM
admet-854	232	58	ionized	ionized	ADJ
admet-854	232	59	amantadine	amantadine	NOUN
admet-854	232	60	interactions	interaction	NOUN
admet-854	232	61	.	.	PUNCT
admet-854	233	1	similarly	similarly	ADV
admet-854	233	2	,	,	PUNCT
admet-854	233	3	amantadine	amantadine	NOUN
admet-854	233	4	–	–	PUNCT
admet-854	233	5	1zn8	1zn8	NUM
admet-854	233	6	interactions	interaction	NOUN
admet-854	233	7	involve	involve	VERB
admet-854	233	8	seven	seven	NUM
admet-854	233	9	amp	amp	NOUN
admet-854	233	10	-	-	PUNCT
admet-854	233	11	binding	bind	VERB
admet-854	233	12	residues	residue	NOUN
admet-854	233	13	.	.	PUNCT
admet-854	234	1	among	among	ADP
admet-854	234	2	them	they	PRON
admet-854	234	3	,	,	PUNCT
admet-854	234	4	four	four	NUM
admet-854	234	5	residues	residue	NOUN
admet-854	234	6	are	be	AUX
admet-854	234	7	the	the	DET
admet-854	234	8	same	same	ADJ
admet-854	234	9	observed	observe	VERB
admet-854	234	10	in	in	ADP
admet-854	234	11	amantadine	amantadine	NOUN
admet-854	234	12	–	–	PUNCT
admet-854	234	13	1zn9	1zn9	NUM
admet-854	234	14	interactions	interaction	NOUN
admet-854	234	15	(	(	PUNCT
admet-854	234	16	asp127	asp127	PROPN
admet-854	234	17	,	,	PUNCT
admet-854	234	18	asp128	asp128	PROPN
admet-854	234	19	,	,	PUNCT
admet-854	234	20	leu129	leu129	PROPN
admet-854	234	21	,	,	PUNCT
admet-854	234	22	and	and	CCONJ
admet-854	234	23	ala131	ala131	PROPN
admet-854	234	24	)	)	PUNCT
admet-854	234	25	(	(	PUNCT
admet-854	234	26	figure	figure	NOUN
admet-854	234	27	14	14	NUM
admet-854	234	28	)	)	PUNCT
admet-854	234	29	.	.	PUNCT
admet-854	235	1	asp127	asp127	NOUN
admet-854	235	2	:	:	PUNCT
admet-854	235	3	od2	od2	NOUN
admet-854	235	4	-	-	PUNCT
admet-854	235	5	n1	n1	NOUN
admet-854	235	6	2.68	2.68	NUM
admet-854	235	7	å	å	PROPN
admet-854	235	8	asp128	asp128	NOUN
admet-854	235	9	:	:	PUNCT
admet-854	235	10	od2	od2	NOUN
admet-854	235	11	-	-	PUNCT
admet-854	235	12	h27	h27	NOUN
admet-854	235	13	2.23	2.23	NUM
admet-854	235	14	å	å	NOUN
admet-854	235	15	asp128	asp128	NOUN
admet-854	235	16	:	:	PUNCT
admet-854	235	17	od2	od2	NOUN
admet-854	235	18	-	-	PUNCT
admet-854	235	19	h5	h5	NOUN
admet-854	235	20	192	192	NUM
admet-854	235	21	å	å	PROPN
admet-854	235	22	ala131	ala131	PROPN
admet-854	235	23	4.26	4.26	NUM
admet-854	235	24	å	å	PROPN
admet-854	235	25	leu129	leu129	PROPN
admet-854	235	26	4.87	4.87	NUM
admet-854	235	27	å	å	PROPN
admet-854	235	28	leu129	leu129	PROPN
admet-854	235	29	5.01	5.01	NUM
admet-854	235	30	å	å	PROPN
admet-854	235	31	leu103	leu103	PROPN
admet-854	235	32	5.45	5.45	NUM
admet-854	235	33	å	å	X
admet-854	235	34	(	(	PUNCT
admet-854	235	35	a	a	NOUN
admet-854	235	36	)	)	PUNCT
admet-854	235	37	(	(	PUNCT
admet-854	235	38	b	b	X
admet-854	235	39	)	)	PUNCT
admet-854	235	40	(	(	PUNCT
admet-854	235	41	c	c	X
admet-854	235	42	)	)	PUNCT
admet-854	235	43	14	14	NUM
admet-854	235	44	.	.	PUNCT
admet-854	236	1	interactions	interaction	NOUN
admet-854	236	2	of	of	ADP
admet-854	236	3	ionized	ionized	ADJ
admet-854	236	4	amantadine	amantadine	NOUN
admet-854	236	5	with	with	ADP
admet-854	236	6	aprt	aprt	PROPN
admet-854	236	7	co	co	VERB
admet-854	236	8	-	-	VERB
admet-854	236	9	crystallized	crystallize	VERB
admet-854	236	10	with	with	ADP
admet-854	236	11	amp	amp	PROPN
admet-854	236	12	,	,	PUNCT
admet-854	236	13	pdb	pdb	PROPN
admet-854	237	1	i	i	PROPN
admet-854	237	2	d	d	PROPN
admet-854	237	3	1zn8	1zn8	NUM
admet-854	237	4	.	.	PUNCT
admet-854	238	1	(	(	PUNCT
admet-854	238	2	a	a	X
admet-854	238	3	)	)	PUNCT
admet-854	238	4	3d	3d	NUM
admet-854	238	5	display	display	NOUN
admet-854	238	6	of	of	ADP
admet-854	238	7	the	the	DET
admet-854	238	8	amantadine	amantadine	NOUN
admet-854	238	9	(	(	PUNCT
admet-854	238	10	shows	show	NOUN
admet-854	238	11	in	in	ADP
admet-854	238	12	yellow	yellow	ADJ
admet-854	238	13	)	)	PUNCT
admet-854	238	14	and	and	CCONJ
admet-854	238	15	amp	amp	NOUN
admet-854	238	16	in	in	ADP
admet-854	238	17	binding	bind	VERB
admet-854	238	18	pocket	pocket	NOUN
admet-854	238	19	;	;	PUNCT
admet-854	238	20	(	(	PUNCT
admet-854	238	21	b	b	X
admet-854	238	22	)	)	PUNCT
admet-854	238	23	code	code	NOUN
admet-854	238	24	color	color	NOUN
admet-854	238	25	for	for	ADP
admet-854	238	26	interactions	interaction	NOUN
admet-854	238	27	:	:	PUNCT
admet-854	238	28	in	in	ADP
admet-854	238	29	orange	orange	NOUN
admet-854	238	30	are	be	AUX
admet-854	238	31	shown	show	VERB
admet-854	238	32	the	the	DET
admet-854	238	33	salt	salt	NOUN
admet-854	238	34	bridges	bridge	NOUN
admet-854	238	35	,	,	PUNCT
admet-854	238	36	light	light	ADJ
admet-854	238	37	green	green	ADJ
admet-854	238	38	–	–	PUNCT
admet-854	238	39	van	van	PROPN
admet-854	238	40	der	der	NOUN
admet-854	238	41	waals	waal	NOUN
admet-854	238	42	forces	force	NOUN
admet-854	238	43	,	,	PUNCT
admet-854	238	44	mauve	mauve	NOUN
admet-854	238	45	–	–	PUNCT
admet-854	238	46	alkyl	alkyl	ADJ
admet-854	238	47	hydrophobic	hydrophobic	NOUN
admet-854	238	48	interactions	interaction	NOUN
admet-854	238	49	;	;	PUNCT
admet-854	238	50	(	(	PUNCT
admet-854	238	51	c	c	X
admet-854	238	52	)	)	PUNCT
admet-854	238	53	the	the	DET
admet-854	238	54	distances	distance	NOUN
admet-854	238	55	(	(	PUNCT
admet-854	238	56	å	å	NOUN
admet-854	238	57	)	)	PUNCT
admet-854	238	58	of	of	ADP
admet-854	238	59	the	the	DET
admet-854	238	60	1zn8	1zn8	NUM
admet-854	238	61	ionized	ionized	ADJ
admet-854	238	62	amantadine	amantadine	NOUN
admet-854	238	63	interactions	interaction	NOUN
admet-854	238	64	.	.	PUNCT
admet-854	239	1	admet	admet	PROPN
admet-854	239	2	&	&	CCONJ
admet-854	239	3	dmpk	dmpk	PROPN
admet-854	239	4	8(2	8(2	NUM
admet-854	239	5	)	)	PUNCT
admet-854	239	6	(	(	PUNCT
admet-854	239	7	2020	2020	NUM
admet-854	239	8	)	)	PUNCT
admet-854	239	9	149	149	NUM
admet-854	239	10	-	-	SYM
admet-854	239	11	175	175	NUM
admet-854	239	12	amantadine	amantadine	NOUN
admet-854	239	13	binding	bind	VERB
admet-854	239	14	to	to	ADP
admet-854	239	15	the	the	DET
admet-854	239	16	enzymes	enzyme	NOUN
admet-854	239	17	regulated	regulate	VERB
admet-854	239	18	in	in	ADP
admet-854	239	19	parkinson	parkinson	NOUN
admet-854	239	20	’s	’s	PART
admet-854	239	21	disease	disease	NOUN
admet-854	239	22	doi	doi	PROPN
admet-854	239	23	:	:	PUNCT
admet-854	239	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	239	25	163	163	NUM
admet-854	239	26	the	the	DET
admet-854	239	27	other	other	ADJ
admet-854	239	28	two	two	NUM
admet-854	239	29	aprt	aprt	NOUN
admet-854	239	30	structures	structure	NOUN
admet-854	239	31	co	co	VERB
admet-854	239	32	-	-	VERB
admet-854	239	33	crystallized	crystallize	VERB
admet-854	239	34	with	with	ADP
admet-854	239	35	amp	amp	PROPN
admet-854	239	36	show	show	VERB
admet-854	239	37	different	different	ADJ
admet-854	239	38	interactions	interaction	NOUN
admet-854	239	39	.	.	PUNCT
admet-854	240	1	among	among	ADP
admet-854	240	2	the	the	DET
admet-854	240	3	eight	eight	NUM
admet-854	240	4	residues	residue	NOUN
admet-854	240	5	of	of	ADP
admet-854	240	6	1ore	1ore	NUM
admet-854	240	7	that	that	PRON
admet-854	240	8	interact	interact	VERB
admet-854	240	9	with	with	ADP
admet-854	240	10	amantadine	amantadine	NOUN
admet-854	240	11	only	only	ADV
admet-854	240	12	two	two	NUM
admet-854	240	13	are	be	AUX
admet-854	240	14	amp	amp	NOUN
admet-854	240	15	-	-	PUNCT
admet-854	240	16	binding	bind	VERB
admet-854	240	17	residues	residue	NOUN
admet-854	240	18	(	(	PUNCT
admet-854	240	19	val25	val25	NOUN
admet-854	240	20	and	and	CCONJ
admet-854	240	21	arg27	arg27	NOUN
admet-854	240	22	)	)	PUNCT
admet-854	240	23	(	(	PUNCT
admet-854	240	24	figure	figure	NOUN
admet-854	240	25	15	15	NUM
admet-854	240	26	)	)	PUNCT
admet-854	240	27	.	.	PUNCT
admet-854	241	1	ser161	ser161	PROPN
admet-854	241	2	:	:	PUNCT
admet-854	241	3	og	og	PROPN
admet-854	241	4	-	-	PUNCT
admet-854	241	5	h27	h27	PROPN
admet-854	241	6	2.04	2.04	NUM
admet-854	241	7	å	å	PROPN
admet-854	241	8	glu180	glu180	NOUN
admet-854	241	9	:	:	PUNCT
admet-854	241	10	oxt	oxt	ADJ
admet-854	241	11	-	-	PUNCT
admet-854	241	12	h27	h27	NOUN
admet-854	241	13	2.31	2.31	NUM
admet-854	241	14	å	å	PROPN
admet-854	241	15	glu180	glu180	PROPN
admet-854	241	16	:o	:o	PROPN
admet-854	241	17	-	-	PUNCT
admet-854	241	18	h28	h28	NOUN
admet-854	241	19	1.85	1.85	NUM
admet-854	241	20	å	å	PROPN
admet-854	241	21	val24	val24	NOUN
admet-854	241	22	4.29	4.29	NUM
admet-854	241	23	å	å	PROPN
admet-854	241	24	val25	val25	NOUN
admet-854	241	25	4.22	4.22	NUM
admet-854	241	26	å	å	PROPN
admet-854	241	27	val24	val24	NOUN
admet-854	241	28	-	-	PUNCT
admet-854	241	29	c9	c9	NOUN
admet-854	241	30	4.28	4.28	NUM
admet-854	241	31	å	å	DET
admet-854	241	32	val25	val25	PROPN
admet-854	241	33	-	-	PUNCT
admet-854	241	34	c9	c9	NOUN
admet-854	241	35	4.69	4.69	NUM
admet-854	241	36	å	å	DET
admet-854	241	37	leu159	leu159	PROPN
admet-854	241	38	-	-	PUNCT
admet-854	241	39	c9	c9	NOUN
admet-854	241	40	4.85	4.85	NUM
admet-854	241	41	å	å	PROPN
admet-854	241	42	(	(	PUNCT
admet-854	241	43	a	a	NOUN
admet-854	241	44	)	)	PUNCT
admet-854	241	45	(	(	PUNCT
admet-854	241	46	b	b	X
admet-854	241	47	)	)	PUNCT
admet-854	241	48	(	(	PUNCT
admet-854	241	49	c	c	X
admet-854	241	50	)	)	PUNCT
admet-854	241	51	figure	figure	NOUN
admet-854	241	52	15	15	NUM
admet-854	241	53	.	.	PUNCT
admet-854	242	1	interactions	interaction	NOUN
admet-854	242	2	of	of	ADP
admet-854	242	3	ionized	ionized	ADJ
admet-854	242	4	amantadine	amantadine	NOUN
admet-854	242	5	with	with	ADP
admet-854	242	6	aprt	aprt	PROPN
admet-854	242	7	co	co	VERB
admet-854	242	8	-	-	VERB
admet-854	242	9	crystallized	crystallize	VERB
admet-854	242	10	with	with	ADP
admet-854	242	11	amp	amp	PROPN
admet-854	242	12	,	,	PUNCT
admet-854	242	13	pdb	pdb	PROPN
admet-854	243	1	i	i	PROPN
admet-854	243	2	d	d	PROPN
admet-854	243	3	1ore	1ore	NUM
admet-854	243	4	.	.	PUNCT
admet-854	244	1	(	(	PUNCT
admet-854	244	2	a	a	X
admet-854	244	3	)	)	PUNCT
admet-854	244	4	3d	3d	NUM
admet-854	244	5	display	display	NOUN
admet-854	244	6	of	of	ADP
admet-854	244	7	the	the	DET
admet-854	244	8	amantadine	amantadine	NOUN
admet-854	244	9	(	(	PUNCT
admet-854	244	10	shows	show	NOUN
admet-854	244	11	in	in	ADP
admet-854	244	12	yellow	yellow	ADJ
admet-854	244	13	)	)	PUNCT
admet-854	244	14	and	and	CCONJ
admet-854	244	15	amp	amp	NOUN
admet-854	244	16	in	in	ADP
admet-854	244	17	binding	bind	VERB
admet-854	244	18	pocket	pocket	NOUN
admet-854	244	19	;	;	PUNCT
admet-854	244	20	(	(	PUNCT
admet-854	244	21	b	b	X
admet-854	244	22	)	)	PUNCT
admet-854	244	23	code	code	NOUN
admet-854	244	24	color	color	NOUN
admet-854	244	25	for	for	ADP
admet-854	244	26	interactions	interaction	NOUN
admet-854	244	27	:	:	PUNCT
admet-854	244	28	in	in	ADP
admet-854	244	29	orange	orange	NOUN
admet-854	244	30	are	be	AUX
admet-854	244	31	shown	show	VERB
admet-854	244	32	the	the	DET
admet-854	244	33	salt	salt	NOUN
admet-854	244	34	bridges	bridge	NOUN
admet-854	244	35	,	,	PUNCT
admet-854	244	36	light	light	ADJ
admet-854	244	37	green	green	ADJ
admet-854	244	38	–	–	PUNCT
admet-854	244	39	van	van	PROPN
admet-854	244	40	der	der	NOUN
admet-854	244	41	waals	waal	NOUN
admet-854	244	42	forces	force	NOUN
admet-854	244	43	,	,	PUNCT
admet-854	244	44	mauve	mauve	NOUN
admet-854	244	45	–	–	PUNCT
admet-854	244	46	alkyl	alkyl	ADJ
admet-854	244	47	hydrophobic	hydrophobic	NOUN
admet-854	244	48	interactions	interaction	NOUN
admet-854	244	49	;	;	PUNCT
admet-854	244	50	(	(	PUNCT
admet-854	244	51	c	c	X
admet-854	244	52	)	)	PUNCT
admet-854	244	53	the	the	DET
admet-854	244	54	distances	distance	NOUN
admet-854	244	55	(	(	PUNCT
admet-854	244	56	å	å	NOUN
admet-854	244	57	)	)	PUNCT
admet-854	244	58	of	of	ADP
admet-854	244	59	the	the	DET
admet-854	244	60	1ore	1ore	NUM
admet-854	244	61	ionized	ionize	VERB
admet-854	244	62	amantadine	amantadine	NOUN
admet-854	244	63	interactions	interaction	NOUN
admet-854	244	64	.	.	PUNCT
admet-854	245	1	the	the	DET
admet-854	245	2	molecular	molecular	ADJ
admet-854	245	3	docking	docking	NOUN
admet-854	245	4	of	of	ADP
admet-854	245	5	amantadine	amantadine	NOUN
admet-854	245	6	with	with	ADP
admet-854	245	7	4x44	4x44	NOUN
admet-854	245	8	results	result	NOUN
admet-854	245	9	in	in	ADP
admet-854	245	10	similar	similar	ADJ
admet-854	245	11	interactions	interaction	NOUN
admet-854	245	12	with	with	ADP
admet-854	245	13	1ore	1ore	NUM
admet-854	245	14	.	.	PUNCT
admet-854	246	1	there	there	PRON
admet-854	246	2	are	be	VERB
admet-854	246	3	three	three	NUM
admet-854	246	4	amp	amp	NOUN
admet-854	246	5	-	-	PUNCT
admet-854	246	6	binding	bind	VERB
admet-854	246	7	residues	residue	NOUN
admet-854	246	8	that	that	PRON
admet-854	246	9	bind	bind	VERB
admet-854	246	10	amantadine	amantadine	NOUN
admet-854	246	11	(	(	PUNCT
admet-854	246	12	val25	val25	NOUN
admet-854	246	13	,	,	PUNCT
admet-854	246	14	arg27	arg27	NOUN
admet-854	246	15	,	,	PUNCT
admet-854	246	16	and	and	CCONJ
admet-854	246	17	leu159	leu159	PROPN
admet-854	246	18	)	)	PUNCT
admet-854	246	19	(	(	PUNCT
admet-854	246	20	figure	figure	NOUN
admet-854	246	21	16	16	NUM
admet-854	246	22	)	)	PUNCT
admet-854	246	23	.	.	PUNCT
admet-854	247	1	ser161	ser161	PROPN
admet-854	247	2	:	:	PUNCT
admet-854	247	3	og	og	PROPN
admet-854	247	4	-	-	PUNCT
admet-854	247	5	h5	h5	PROPN
admet-854	247	6	2.33	2.33	NUM
admet-854	247	7	å	å	PROPN
admet-854	247	8	glu180	glu180	NOUN
admet-854	247	9	:	:	PUNCT
admet-854	247	10	oxt	oxt	ADJ
admet-854	247	11	-	-	PUNCT
admet-854	247	12	h5	h5	NOUN
admet-854	247	13	2.29	2.29	NUM
admet-854	247	14	å	å	PROPN
admet-854	247	15	glu180	glu180	PROPN
admet-854	247	16	:o	:o	PROPN
admet-854	247	17	-	-	PUNCT
admet-854	247	18	h27	h27	PROPN
admet-854	247	19	1.90	1.90	NUM
admet-854	247	20	å	å	PROPN
admet-854	247	21	val24	val24	NOUN
admet-854	247	22	4.81	4.81	NUM
admet-854	247	23	å	å	PROPN
admet-854	247	24	val25	val25	NOUN
admet-854	247	25	4.78	4.78	NUM
admet-854	247	26	å	å	PROPN
admet-854	247	27	val25	val25	PROPN
admet-854	247	28	-	-	PUNCT
admet-854	247	29	c10	c10	VERB
admet-854	247	30	3.68	3.68	NUM
admet-854	247	31	å	å	PROPN
admet-854	247	32	leu159	leu159	PROPN
admet-854	247	33	4.86	4.86	NUM
admet-854	247	34	å	å	PROPN
admet-854	247	35	(	(	PUNCT
admet-854	247	36	a	a	NOUN
admet-854	247	37	)	)	PUNCT
admet-854	247	38	(	(	PUNCT
admet-854	247	39	b	b	X
admet-854	247	40	)	)	PUNCT
admet-854	247	41	(	(	PUNCT
admet-854	247	42	c	c	X
admet-854	247	43	)	)	PUNCT
admet-854	247	44	figure	figure	NOUN
admet-854	247	45	16	16	NUM
admet-854	247	46	.	.	PUNCT
admet-854	248	1	interactions	interaction	NOUN
admet-854	248	2	of	of	ADP
admet-854	248	3	ionized	ionized	ADJ
admet-854	248	4	amantadine	amantadine	NOUN
admet-854	248	5	with	with	ADP
admet-854	248	6	aprt	aprt	PROPN
admet-854	248	7	co	co	VERB
admet-854	248	8	-	-	VERB
admet-854	248	9	crystallized	crystallize	VERB
admet-854	248	10	with	with	ADP
admet-854	248	11	amp	amp	PROPN
admet-854	248	12	,	,	PUNCT
admet-854	248	13	pdb	pdb	PROPN
admet-854	248	14	i	i	PROPN
admet-854	248	15	d	d	PROPN
admet-854	248	16	4x44	4x44	PROPN
admet-854	248	17	.	.	PUNCT
admet-854	249	1	(	(	PUNCT
admet-854	249	2	a	a	X
admet-854	249	3	)	)	PUNCT
admet-854	249	4	3d	3d	NUM
admet-854	249	5	display	display	NOUN
admet-854	249	6	of	of	ADP
admet-854	249	7	the	the	DET
admet-854	249	8	amantadine	amantadine	NOUN
admet-854	249	9	(	(	PUNCT
admet-854	249	10	shows	show	NOUN
admet-854	249	11	in	in	ADP
admet-854	249	12	yellow	yellow	ADJ
admet-854	249	13	)	)	PUNCT
admet-854	249	14	and	and	CCONJ
admet-854	249	15	amp	amp	NOUN
admet-854	249	16	in	in	ADP
admet-854	249	17	binding	bind	VERB
admet-854	249	18	pocket	pocket	NOUN
admet-854	249	19	;	;	PUNCT
admet-854	249	20	(	(	PUNCT
admet-854	249	21	b	b	X
admet-854	249	22	)	)	PUNCT
admet-854	249	23	code	code	NOUN
admet-854	249	24	color	color	NOUN
admet-854	249	25	for	for	ADP
admet-854	249	26	interactions	interaction	NOUN
admet-854	249	27	:	:	PUNCT
admet-854	249	28	in	in	ADP
admet-854	249	29	orange	orange	NOUN
admet-854	249	30	are	be	AUX
admet-854	249	31	shown	show	VERB
admet-854	249	32	the	the	DET
admet-854	249	33	salt	salt	NOUN
admet-854	249	34	bridges	bridge	NOUN
admet-854	249	35	,	,	PUNCT
admet-854	249	36	light	light	ADJ
admet-854	249	37	green	green	ADJ
admet-854	249	38	–	–	PUNCT
admet-854	249	39	van	van	PROPN
admet-854	249	40	der	der	NOUN
admet-854	249	41	waals	waal	NOUN
admet-854	249	42	forces	force	NOUN
admet-854	249	43	,	,	PUNCT
admet-854	249	44	mauve	mauve	NOUN
admet-854	249	45	–	–	PUNCT
admet-854	249	46	alkyl	alkyl	ADJ
admet-854	249	47	hydrophobic	hydrophobic	NOUN
admet-854	249	48	interactions	interaction	NOUN
admet-854	249	49	;	;	PUNCT
admet-854	249	50	(	(	PUNCT
admet-854	249	51	c	c	X
admet-854	249	52	)	)	PUNCT
admet-854	249	53	the	the	DET
admet-854	249	54	distances	distance	NOUN
admet-854	249	55	(	(	PUNCT
admet-854	249	56	å	å	NOUN
admet-854	249	57	)	)	PUNCT
admet-854	249	58	of	of	ADP
admet-854	249	59	the	the	DET
admet-854	249	60	4x44	4x44	NOUN
admet-854	249	61	ionized	ionize	VERB
admet-854	249	62	amantadine	amantadine	NOUN
admet-854	249	63	interactions	interaction	NOUN
admet-854	249	64	.	.	PUNCT
admet-854	250	1	the	the	DET
admet-854	250	2	human	human	PROPN
admet-854	250	3	aprt	aprt	PROPN
admet-854	250	4	co	co	VERB
admet-854	250	5	-	-	VERB
admet-854	250	6	crystallized	crystallize	VERB
admet-854	250	7	with	with	ADP
admet-854	250	8	adenine	adenine	NOUN
admet-854	250	9	(	(	PUNCT
admet-854	250	10	pdb	pdb	NOUN
admet-854	250	11	id(s	id(s	SYM
admet-854	250	12	)	)	PUNCT
admet-854	250	13	6fci	6fci	NOUN
admet-854	250	14	and	and	CCONJ
admet-854	250	15	1zn7	1zn7	NUM
admet-854	250	16	)	)	PUNCT
admet-854	250	17	allows	allow	VERB
admet-854	250	18	a	a	DET
admet-854	250	19	deeper	deep	ADJ
admet-854	250	20	view	view	NOUN
admet-854	250	21	of	of	ADP
admet-854	250	22	the	the	DET
admet-854	250	23	amantadine	amantadine	NOUN
admet-854	250	24	interactions	interaction	NOUN
admet-854	250	25	with	with	ADP
admet-854	250	26	this	this	DET
admet-854	250	27	enzyme	enzyme	NOUN
admet-854	250	28	.	.	PUNCT
admet-854	251	1	the	the	DET
admet-854	251	2	two	two	NUM
admet-854	251	3	structures	structure	NOUN
admet-854	251	4	have	have	VERB
admet-854	251	5	different	different	ADJ
admet-854	251	6	behavior	behavior	NOUN
admet-854	251	7	when	when	SCONJ
admet-854	251	8	docked	dock	VERB
admet-854	251	9	with	with	ADP
admet-854	251	10	amantadine	amantadine	NOUN
admet-854	251	11	.	.	PUNCT
admet-854	252	1	thus	thus	ADV
admet-854	252	2	,	,	PUNCT
admet-854	252	3	among	among	ADP
admet-854	252	4	ten	ten	NUM
admet-854	252	5	residues	residue	NOUN
admet-854	252	6	of	of	ADP
admet-854	252	7	the	the	DET
admet-854	252	8	6fci	6fci	NOUN
admet-854	252	9	that	that	PRON
admet-854	252	10	interact	interact	VERB
admet-854	252	11	with	with	ADP
admet-854	252	12	amantadine	amantadine	NOUN
admet-854	252	13	,	,	PUNCT
admet-854	252	14	five	five	NUM
admet-854	252	15	bind	bind	NOUN
admet-854	252	16	adenine	adenine	NOUN
admet-854	252	17	(	(	PUNCT
admet-854	252	18	glu104	glu104	PROPN
admet-854	252	19	,	,	PUNCT
admet-854	252	20	arg67	arg67	PROPN
admet-854	252	21	,	,	PUNCT
admet-854	252	22	leu129	leu129	PROPN
admet-854	252	23	,	,	PUNCT
admet-854	252	24	tyr105	tyr105	PROPN
admet-854	252	25	,	,	PUNCT
admet-854	252	26	and	and	CCONJ
admet-854	252	27	ala131	ala131	PROPN
admet-854	252	28	)	)	PUNCT
admet-854	252	29	(	(	PUNCT
admet-854	252	30	figure	figure	NOUN
admet-854	252	31	17	17	NUM
admet-854	252	32	)	)	PUNCT
admet-854	252	33	.	.	PUNCT
admet-854	253	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	253	2	mihaela	mihaela	PROPN
admet-854	253	3	ileana	ileana	PROPN
admet-854	253	4	ionescu	ionescu	PROPN
admet-854	253	5	admet	admet	PROPN
admet-854	253	6	&	&	CCONJ
admet-854	253	7	dmpk	dmpk	PROPN
admet-854	253	8	8(2	8(2	NUM
admet-854	253	9	)	)	PUNCT
admet-854	253	10	(	(	PUNCT
admet-854	253	11	2020	2020	NUM
admet-854	253	12	)	)	PUNCT
admet-854	253	13	149	149	NUM
admet-854	253	14	-	-	SYM
admet-854	253	15	175	175	NUM
admet-854	253	16	164	164	NUM
admet-854	253	17	leu129	leu129	PROPN
admet-854	253	18	:o	:o	PROPN
admet-854	253	19	-	-	PUNCT
admet-854	253	20	h5	h5	PROPN
admet-854	253	21	2.05	2.05	NUM
admet-854	253	22	å	å	PRON
admet-854	253	23	asp127	asp127	NOUN
admet-854	253	24	-	-	PUNCT
admet-854	253	25	od1	od1	NOUN
admet-854	253	26	1.75	1.75	NUM
admet-854	253	27	å	å	PROPN
admet-854	253	28	asp128	asp128	NOUN
admet-854	253	29	:	:	PUNCT
admet-854	253	30	od2	od2	NOUN
admet-854	253	31	1.81	1.81	NUM
admet-854	253	32	å	å	PROPN
admet-854	253	33	ala131	ala131	PROPN
admet-854	253	34	5.09	5.09	NUM
admet-854	253	35	å	å	PROPN
admet-854	253	36	ala131	ala131	PROPN
admet-854	253	37	-	-	PUNCT
admet-854	253	38	c10	c10	VERB
admet-854	253	39	3.35	3.35	NUM
admet-854	253	40	å	å	X
admet-854	253	41	ala129	ala129	PROPN
admet-854	253	42	4.85	4.85	NUM
admet-854	254	1	å	å	NOUN
admet-854	254	2	leu103	leu103	NOUN
admet-854	254	3	4.29	4.29	NUM
admet-854	254	4	å	å	PROPN
admet-854	254	5	leu129	leu129	PROPN
admet-854	254	6	-	-	PUNCT
admet-854	254	7	c10	c10	VERB
admet-854	254	8	4.47	4.47	NUM
admet-854	254	9	å	å	PROPN
admet-854	254	10	tyr105	tyr105	PROPN
admet-854	254	11	5.16	5.16	NUM
admet-854	254	12	å	å	PROPN
admet-854	254	13	(	(	PUNCT
admet-854	254	14	a	a	NOUN
admet-854	254	15	)	)	PUNCT
admet-854	254	16	(	(	PUNCT
admet-854	254	17	b	b	X
admet-854	254	18	)	)	PUNCT
admet-854	254	19	(	(	PUNCT
admet-854	254	20	c	c	X
admet-854	254	21	)	)	PUNCT
admet-854	254	22	figure	figure	NOUN
admet-854	254	23	17	17	NUM
admet-854	254	24	.	.	PUNCT
admet-854	255	1	interactions	interaction	NOUN
admet-854	255	2	of	of	ADP
admet-854	255	3	ionized	ionized	ADJ
admet-854	255	4	amantadine	amantadine	NOUN
admet-854	255	5	with	with	ADP
admet-854	255	6	aprt	aprt	PROPN
admet-854	255	7	co	co	VERB
admet-854	255	8	-	-	VERB
admet-854	255	9	crystallized	crystallize	VERB
admet-854	255	10	with	with	ADP
admet-854	255	11	adenine	adenine	NOUN
admet-854	255	12	,	,	PUNCT
admet-854	255	13	pdb	pdb	PROPN
admet-854	255	14	i	i	PROPN
admet-854	255	15	d	d	PROPN
admet-854	255	16	6fci	6fci	PROPN
admet-854	255	17	.	.	PUNCT
admet-854	256	1	(	(	PUNCT
admet-854	256	2	a	a	X
admet-854	256	3	)	)	PUNCT
admet-854	256	4	3d	3d	NUM
admet-854	256	5	display	display	NOUN
admet-854	256	6	of	of	ADP
admet-854	256	7	the	the	DET
admet-854	256	8	amantadine	amantadine	NOUN
admet-854	256	9	(	(	PUNCT
admet-854	256	10	shows	show	NOUN
admet-854	256	11	in	in	ADP
admet-854	256	12	yellow	yellow	ADJ
admet-854	256	13	)	)	PUNCT
admet-854	256	14	and	and	CCONJ
admet-854	256	15	adenine	adenine	NOUN
admet-854	256	16	in	in	ADP
admet-854	256	17	binding	bind	VERB
admet-854	256	18	pocket	pocket	NOUN
admet-854	256	19	;	;	PUNCT
admet-854	256	20	(	(	PUNCT
admet-854	256	21	b	b	X
admet-854	256	22	)	)	PUNCT
admet-854	256	23	code	code	NOUN
admet-854	256	24	color	color	NOUN
admet-854	256	25	for	for	ADP
admet-854	256	26	interactions	interaction	NOUN
admet-854	256	27	:	:	PUNCT
admet-854	256	28	in	in	ADP
admet-854	256	29	orange	orange	NOUN
admet-854	256	30	are	be	AUX
admet-854	256	31	shown	show	VERB
admet-854	256	32	the	the	DET
admet-854	256	33	salt	salt	NOUN
admet-854	256	34	bridges	bridge	NOUN
admet-854	256	35	,	,	PUNCT
admet-854	256	36	light	light	ADJ
admet-854	256	37	green	green	ADJ
admet-854	256	38	–	–	PUNCT
admet-854	256	39	van	van	PROPN
admet-854	256	40	der	der	NOUN
admet-854	256	41	waals	waal	NOUN
admet-854	256	42	forces	force	NOUN
admet-854	256	43	,	,	PUNCT
admet-854	256	44	mauve	mauve	NOUN
admet-854	256	45	–	–	PUNCT
admet-854	256	46	alkyl	alkyl	ADJ
admet-854	256	47	hydrophobic	hydrophobic	NOUN
admet-854	256	48	interactions	interaction	NOUN
admet-854	256	49	;	;	PUNCT
admet-854	256	50	(	(	PUNCT
admet-854	256	51	c	c	X
admet-854	256	52	)	)	PUNCT
admet-854	256	53	the	the	DET
admet-854	256	54	distances	distance	NOUN
admet-854	256	55	(	(	PUNCT
admet-854	256	56	å	å	NOUN
admet-854	256	57	)	)	PUNCT
admet-854	256	58	of	of	ADP
admet-854	256	59	the	the	DET
admet-854	256	60	6fci	6fci	PROPN
admet-854	256	61	ionized	ionize	VERB
admet-854	256	62	amantadine	amantadine	NOUN
admet-854	256	63	interactions	interaction	NOUN
admet-854	256	64	.	.	PUNCT
admet-854	257	1	contrary	contrary	ADJ
admet-854	257	2	,	,	PUNCT
admet-854	257	3	in	in	ADP
admet-854	257	4	the	the	DET
admet-854	257	5	case	case	NOUN
admet-854	257	6	of	of	ADP
admet-854	257	7	1zn7	1zn7	NUM
admet-854	257	8	structure	structure	NOUN
admet-854	257	9	,	,	PUNCT
admet-854	257	10	molecular	molecular	ADJ
admet-854	257	11	docking	docking	NOUN
admet-854	257	12	of	of	ADP
admet-854	257	13	amantadine	amantadine	NOUN
admet-854	257	14	involves	involve	VERB
admet-854	257	15	different	different	ADJ
admet-854	257	16	residues	residue	NOUN
admet-854	257	17	than	than	ADP
admet-854	257	18	adenine	adenine	NOUN
admet-854	257	19	(	(	PUNCT
admet-854	257	20	figure	figure	NOUN
admet-854	257	21	18	18	NUM
admet-854	257	22	)	)	PUNCT
admet-854	257	23	.	.	PUNCT
admet-854	258	1	the	the	DET
admet-854	258	2	last	last	ADJ
admet-854	258	3	two	two	NUM
admet-854	258	4	structures	structure	NOUN
admet-854	258	5	(	(	PUNCT
admet-854	258	6	pdb	pdb	NOUN
admet-854	258	7	id(s	id(s	SYM
admet-854	258	8	)	)	PUNCT
admet-854	258	9	6fci	6fci	NOUN
admet-854	258	10	and	and	CCONJ
admet-854	258	11	1zn7	1zn7	NUM
admet-854	258	12	)	)	PUNCT
admet-854	258	13	,	,	PUNCT
admet-854	258	14	being	be	AUX
admet-854	258	15	co	co	VERB
admet-854	258	16	-	-	VERB
admet-854	258	17	crystallized	crystallize	VERB
admet-854	258	18	with	with	ADP
admet-854	258	19	adenine	adenine	NOUN
admet-854	258	20	,	,	PUNCT
admet-854	258	21	not	not	PART
admet-854	258	22	with	with	ADP
admet-854	258	23	the	the	DET
admet-854	258	24	substrate	substrate	NOUN
admet-854	258	25	amp	amp	NOUN
admet-854	258	26	,	,	PUNCT
admet-854	258	27	should	should	AUX
admet-854	258	28	be	be	AUX
admet-854	258	29	interpreted	interpret	VERB
admet-854	258	30	accordingly	accordingly	ADV
admet-854	258	31	.	.	PUNCT
admet-854	259	1	asp115	asp115	PROPN
admet-854	259	2	:o	:o	PROPN
admet-854	259	3	-	-	PUNCT
admet-854	259	4	h27	h27	PROPN
admet-854	259	5	1.83	1.83	NUM
admet-854	259	6	å	å	PROPN
admet-854	259	7	glu118	glu118	PROPN
admet-854	259	8	:	:	PUNCT
admet-854	259	9	oe1	oe1	ADJ
admet-854	259	10	-	-	PUNCT
admet-854	259	11	h27	h27	NOUN
admet-854	259	12	2.03	2.03	NUM
admet-854	259	13	å	å	PROPN
admet-854	259	14	glu118	glu118	PROPN
admet-854	259	15	:	:	PUNCT
admet-854	259	16	oe1	oe1	NOUN
admet-854	259	17	-	-	PUNCT
admet-854	259	18	h5	h5	NOUN
admet-854	259	19	2.15	2.15	NUM
admet-854	259	20	å	å	PROPN
admet-854	259	21	asp115	asp115	PROPN
admet-854	259	22	:	:	PUNCT
admet-854	259	23	od2	od2	NOUN
admet-854	259	24	-	-	PUNCT
admet-854	259	25	n1	n1	NOUN
admet-854	259	26	5.51	5.51	NUM
admet-854	259	27	å	å	PROPN
admet-854	259	28	glu118	glu118	PROPN
admet-854	259	29	:	:	PUNCT
admet-854	259	30	oe1	oe1	ADJ
admet-854	259	31	-	-	PUNCT
admet-854	259	32	n1	n1	NOUN
admet-854	259	33	4.30	4.30	NUM
admet-854	259	34	å	å	PROPN
admet-854	259	35	tyr60	tyr60	NOUN
admet-854	259	36	4.30	4.30	NUM
admet-854	259	37	å	å	PROPN
admet-854	259	38	tyr60	tyr60	NOUN
admet-854	259	39	-	-	PUNCT
admet-854	259	40	c9	c9	NOUN
admet-854	259	41	5.28	5.28	NUM
admet-854	259	42	å	å	PROPN
admet-854	259	43	(	(	PUNCT
admet-854	259	44	a	a	NOUN
admet-854	259	45	)	)	PUNCT
admet-854	259	46	(	(	PUNCT
admet-854	259	47	b	b	X
admet-854	259	48	)	)	PUNCT
admet-854	259	49	(	(	PUNCT
admet-854	259	50	c	c	X
admet-854	259	51	)	)	PUNCT
admet-854	259	52	figure	figure	NOUN
admet-854	259	53	18	18	NUM
admet-854	259	54	.	.	PUNCT
admet-854	260	1	interactions	interaction	NOUN
admet-854	260	2	of	of	ADP
admet-854	260	3	ionized	ionized	ADJ
admet-854	260	4	amantadine	amantadine	NOUN
admet-854	260	5	with	with	ADP
admet-854	260	6	aprt	aprt	PROPN
admet-854	260	7	co	co	VERB
admet-854	260	8	-	-	VERB
admet-854	260	9	crystallized	crystallize	VERB
admet-854	260	10	with	with	ADP
admet-854	260	11	adenine	adenine	NOUN
admet-854	260	12	,	,	PUNCT
admet-854	260	13	pdb	pdb	PROPN
admet-854	260	14	i	i	PROPN
admet-854	260	15	d	d	PROPN
admet-854	260	16	1zn7	1zn7	NUM
admet-854	260	17	.	.	PUNCT
admet-854	261	1	(	(	PUNCT
admet-854	261	2	a	a	X
admet-854	261	3	)	)	PUNCT
admet-854	261	4	3d	3d	NUM
admet-854	261	5	display	display	NOUN
admet-854	261	6	of	of	ADP
admet-854	261	7	the	the	DET
admet-854	261	8	amantadine	amantadine	NOUN
admet-854	261	9	(	(	PUNCT
admet-854	261	10	shows	show	NOUN
admet-854	261	11	in	in	ADP
admet-854	261	12	yellow	yellow	ADJ
admet-854	261	13	)	)	PUNCT
admet-854	261	14	and	and	CCONJ
admet-854	261	15	adenine	adenine	NOUN
admet-854	261	16	in	in	ADP
admet-854	261	17	binding	bind	VERB
admet-854	261	18	pocket	pocket	NOUN
admet-854	261	19	;	;	PUNCT
admet-854	261	20	(	(	PUNCT
admet-854	261	21	b	b	X
admet-854	261	22	)	)	PUNCT
admet-854	261	23	code	code	NOUN
admet-854	261	24	color	color	NOUN
admet-854	261	25	for	for	ADP
admet-854	261	26	interactions	interaction	NOUN
admet-854	261	27	:	:	PUNCT
admet-854	261	28	in	in	ADP
admet-854	261	29	orange	orange	NOUN
admet-854	261	30	are	be	AUX
admet-854	261	31	shown	show	VERB
admet-854	261	32	the	the	DET
admet-854	261	33	salt	salt	NOUN
admet-854	261	34	bridges	bridge	NOUN
admet-854	261	35	,	,	PUNCT
admet-854	261	36	light	light	ADJ
admet-854	261	37	green	green	ADJ
admet-854	261	38	–	–	PUNCT
admet-854	261	39	van	van	PROPN
admet-854	261	40	der	der	NOUN
admet-854	261	41	waals	waal	NOUN
admet-854	261	42	forces	force	NOUN
admet-854	261	43	,	,	PUNCT
admet-854	261	44	mauve	mauve	NOUN
admet-854	261	45	–	–	PUNCT
admet-854	261	46	alkyl	alkyl	ADJ
admet-854	261	47	hydrophobic	hydrophobic	NOUN
admet-854	261	48	interactions	interaction	NOUN
admet-854	261	49	;	;	PUNCT
admet-854	261	50	(	(	PUNCT
admet-854	261	51	c	c	X
admet-854	261	52	)	)	PUNCT
admet-854	261	53	the	the	DET
admet-854	261	54	distances	distance	NOUN
admet-854	261	55	(	(	PUNCT
admet-854	261	56	å	å	NOUN
admet-854	261	57	)	)	PUNCT
admet-854	261	58	of	of	ADP
admet-854	261	59	the	the	DET
admet-854	261	60	1zn7	1zn7	NUM
admet-854	261	61	ionized	ionized	ADJ
admet-854	261	62	amantadine	amantadine	NOUN
admet-854	261	63	interactions	interaction	NOUN
admet-854	261	64	.	.	PUNCT
admet-854	262	1	molecular	molecular	ADJ
admet-854	262	2	docking	docking	NOUN
admet-854	262	3	of	of	ADP
admet-854	262	4	the	the	DET
admet-854	262	5	human	human	ADJ
admet-854	262	6	ecto-5’-nucleotidase	ecto-5’-nucleotidase	PROPN
admet-854	262	7	(	(	PUNCT
admet-854	262	8	nt5e	nt5e	NOUN
admet-854	262	9	)	)	PUNCT
admet-854	262	10	with	with	ADP
admet-854	262	11	ionized	ionized	ADJ
admet-854	262	12	amantadine	amantadine	NOUN
admet-854	262	13	and	and	CCONJ
admet-854	262	14	the	the	DET
admet-854	262	15	redocking	redocking	NOUN
admet-854	262	16	with	with	ADP
admet-854	262	17	the	the	DET
admet-854	262	18	substrates	substrate	NOUN
admet-854	262	19	the	the	DET
admet-854	262	20	ecto-5’-nucleotidase	ecto-5’-nucleotidase	PROPN
admet-854	262	21	(	(	PUNCT
admet-854	262	22	nt5e	nt5e	PROPN
admet-854	262	23	)	)	PUNCT
admet-854	262	24	(	(	PUNCT
admet-854	262	25	e.c	e.c	PROPN
admet-854	262	26	.	.	PROPN
admet-854	262	27	3.1.3.5	3.1.3.5	NUM
admet-854	262	28	)	)	PUNCT
admet-854	262	29	catalyzes	catalyze	VERB
admet-854	262	30	the	the	DET
admet-854	262	31	hydrolysis	hydrolysis	NOUN
admet-854	262	32	of	of	ADP
admet-854	262	33	extracellular	extracellular	ADJ
admet-854	262	34	amp	amp	NOUN
admet-854	262	35	to	to	PART
admet-854	262	36	adenosine	adenosine	VERB
admet-854	262	37	.	.	PUNCT
admet-854	263	1	all	all	DET
admet-854	263	2	human	human	PROPN
admet-854	263	3	nt5es	nt5es	NUM
admet-854	263	4	found	find	VERB
admet-854	263	5	in	in	ADP
admet-854	263	6	pdb	pdb	PROPN
admet-854	263	7	were	be	AUX
admet-854	263	8	analyzed	analyze	VERB
admet-854	263	9	about	about	ADP
admet-854	263	10	the	the	DET
admet-854	263	11	amantadine	amantadine	NOUN
admet-854	263	12	interactions	interaction	NOUN
admet-854	263	13	.	.	PUNCT
admet-854	264	1	first	first	ADV
admet-854	264	2	,	,	PUNCT
admet-854	264	3	the	the	DET
admet-854	264	4	redock	redock	NOUN
admet-854	264	5	of	of	ADP
admet-854	264	6	the	the	DET
admet-854	264	7	substrates	substrate	NOUN
admet-854	264	8	co	co	VERB
admet-854	264	9	-	-	VERB
admet-854	264	10	crystallized	crystallized	ADJ
admet-854	264	11	in	in	ADP
admet-854	264	12	the	the	DET
admet-854	264	13	x	x	NOUN
admet-854	264	14	-	-	NOUN
admet-854	264	15	ray	ray	ADJ
admet-854	264	16	3d	3d	PROPN
admet-854	264	17	structures	structure	NOUN
admet-854	264	18	was	be	AUX
admet-854	264	19	made	make	VERB
admet-854	264	20	,	,	PUNCT
admet-854	264	21	then	then	ADV
admet-854	264	22	amantadine	amantadine	ADJ
admet-854	264	23	ionized	ionized	ADJ
admet-854	264	24	form	form	NOUN
admet-854	264	25	molecular	molecular	ADJ
admet-854	264	26	docking	docking	NOUN
admet-854	264	27	(	(	PUNCT
admet-854	264	28	table	table	NOUN
admet-854	264	29	3	3	NUM
admet-854	264	30	)	)	PUNCT
admet-854	264	31	.	.	PUNCT
admet-854	265	1	in	in	ADP
admet-854	265	2	all	all	DET
admet-854	265	3	nt5es	nt5es	NUM
admet-854	265	4	structures	structure	NOUN
admet-854	265	5	analyzed	analyze	VERB
admet-854	265	6	,	,	PUNCT
admet-854	265	7	the	the	DET
admet-854	265	8	amanatdine	amanatdine	NOUN
admet-854	265	9	binds	bind	VERB
admet-854	265	10	other	other	ADJ
admet-854	265	11	residues	residue	NOUN
admet-854	265	12	than	than	ADP
admet-854	265	13	the	the	DET
admet-854	265	14	substrate	substrate	NOUN
admet-854	265	15	-	-	PUNCT
admet-854	265	16	binding	bind	VERB
admet-854	265	17	region	region	NOUN
admet-854	265	18	(	(	PUNCT
admet-854	265	19	data	datum	NOUN
admet-854	265	20	not	not	PART
admet-854	265	21	shown	show	VERB
admet-854	265	22	)	)	PUNCT
admet-854	265	23	.	.	PUNCT
admet-854	266	1	molecular	molecular	ADJ
admet-854	266	2	docking	docking	NOUN
admet-854	266	3	of	of	ADP
admet-854	266	4	the	the	DET
admet-854	266	5	human	human	ADJ
admet-854	266	6	ectonucleoside	ectonucleoside	NOUN
admet-854	266	7	triphosphate	triphosphate	NOUN
admet-854	266	8	diphosphohydrolase	diphosphohydrolase	NOUN
admet-854	266	9	1	1	NUM
admet-854	266	10	with	with	ADP
admet-854	266	11	ionized	ionized	ADJ
admet-854	266	12	amantadine	amantadine	NOUN
admet-854	266	13	and	and	CCONJ
admet-854	266	14	the	the	DET
admet-854	266	15	redocking	redocking	NOUN
admet-854	266	16	with	with	ADP
admet-854	266	17	the	the	DET
admet-854	266	18	substrates	substrate	NOUN
admet-854	266	19	the	the	DET
admet-854	266	20	ectonucleoside	ectonucleoside	ADJ
admet-854	266	21	triphosphate	triphosphate	NOUN
admet-854	266	22	diphosphohydrolase	diphosphohydrolase	NOUN
admet-854	266	23	1	1	NUM
admet-854	266	24	(	(	PUNCT
admet-854	266	25	entpd1	entpd1	NOUN
admet-854	266	26	)	)	PUNCT
admet-854	266	27	(	(	PUNCT
admet-854	266	28	e.c	e.c	PROPN
admet-854	266	29	.	.	NOUN
admet-854	266	30	3.6.1.5	3.6.1.5	NUM
admet-854	266	31	)	)	PUNCT
admet-854	266	32	catalyzes	catalyze	VERB
admet-854	266	33	the	the	DET
admet-854	266	34	reaction	reaction	NOUN
admet-854	266	35	:	:	PUNCT
admet-854	266	36	a	a	DET
admet-854	266	37	ribonucleoside	ribonucleoside	NOUN
admet-854	266	38	5’-triphosphate	5’-triphosphate	NUM
admet-854	266	39	+	+	CCONJ
admet-854	266	40	2h2o	2h2o	NOUN
admet-854	266	41	=	=	PUNCT
admet-854	266	42	a	a	DET
admet-854	266	43	ribonucleoside	ribonucleoside	NOUN
admet-854	266	44	5’-triphosphate	5’-triphosphate	NUM
admet-854	266	45	+2h+	+2h+	X
admet-854	267	1	+	+	CCONJ
admet-854	268	1	2phosphate	2phosphate	X
admet-854	268	2	.	.	PUNCT
admet-854	268	3	because	because	SCONJ
admet-854	268	4	there	there	PRON
admet-854	268	5	are	be	VERB
admet-854	268	6	no	no	DET
admet-854	268	7	matching	match	VERB
admet-854	268	8	pdb	pdb	NOUN
admet-854	268	9	entries	entry	NOUN
admet-854	268	10	for	for	ADP
admet-854	268	11	human	human	ADJ
admet-854	268	12	entdp1	entdp1	PROPN
admet-854	268	13	,	,	PUNCT
admet-854	268	14	were	be	AUX
admet-854	268	15	analyzed	analyze	VERB
admet-854	268	16	the	the	DET
admet-854	268	17	entdp1	entdp1	NOUN
admet-854	268	18	from	from	ADP
admet-854	268	19	rattus	rattus	PROPN
admet-854	268	20	norvegicus	norvegicus	PROPN
admet-854	268	21	.	.	PUNCT
admet-854	269	1	admet	admet	PROPN
admet-854	269	2	&	&	CCONJ
admet-854	269	3	dmpk	dmpk	PROPN
admet-854	269	4	8(2	8(2	NUM
admet-854	269	5	)	)	PUNCT
admet-854	269	6	(	(	PUNCT
admet-854	269	7	2020	2020	NUM
admet-854	269	8	)	)	PUNCT
admet-854	269	9	149	149	NUM
admet-854	269	10	-	-	SYM
admet-854	269	11	175	175	NUM
admet-854	269	12	amantadine	amantadine	NOUN
admet-854	269	13	binding	bind	VERB
admet-854	269	14	to	to	ADP
admet-854	269	15	the	the	DET
admet-854	269	16	enzymes	enzyme	NOUN
admet-854	269	17	regulated	regulate	VERB
admet-854	269	18	in	in	ADP
admet-854	269	19	parkinson	parkinson	NOUN
admet-854	269	20	’s	’s	PART
admet-854	269	21	disease	disease	NOUN
admet-854	269	22	doi	doi	PROPN
admet-854	269	23	:	:	PUNCT
admet-854	269	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	269	25	165	165	NUM
admet-854	269	26	although	although	SCONJ
admet-854	269	27	the	the	DET
admet-854	269	28	interpretation	interpretation	NOUN
admet-854	269	29	of	of	ADP
admet-854	269	30	the	the	DET
admet-854	269	31	molecular	molecular	ADJ
admet-854	269	32	docking	docking	NOUN
admet-854	269	33	of	of	ADP
admet-854	269	34	amantadine	amantadine	NOUN
admet-854	269	35	is	be	AUX
admet-854	269	36	not	not	PART
admet-854	269	37	reliable	reliable	ADJ
admet-854	269	38	,	,	PUNCT
admet-854	269	39	because	because	SCONJ
admet-854	269	40	the	the	DET
admet-854	269	41	crystal	crystal	NOUN
admet-854	269	42	structures	structure	NOUN
admet-854	269	43	are	be	AUX
admet-854	269	44	not	not	PART
admet-854	269	45	with	with	ADP
admet-854	269	46	the	the	DET
admet-854	269	47	substrates	substrate	NOUN
admet-854	269	48	,	,	PUNCT
admet-854	269	49	it	it	PRON
admet-854	269	50	is	be	AUX
admet-854	269	51	worth	worth	ADJ
admet-854	269	52	noticing	notice	VERB
admet-854	269	53	that	that	SCONJ
admet-854	269	54	the	the	DET
admet-854	269	55	molecular	molecular	ADJ
admet-854	269	56	docking	docking	NOUN
admet-854	269	57	of	of	ADP
admet-854	269	58	the	the	DET
admet-854	269	59	3zx2	3zx2	NUM
admet-854	269	60	with	with	ADP
admet-854	269	61	amantadine	amantadine	NOUN
admet-854	269	62	results	result	NOUN
admet-854	269	63	in	in	ADP
admet-854	269	64	an	an	DET
admet-854	269	65	interaction	interaction	NOUN
admet-854	269	66	with	with	ADP
admet-854	269	67	the	the	DET
admet-854	269	68	active	active	ADJ
admet-854	269	69	-	-	PUNCT
admet-854	269	70	site	site	NOUN
admet-854	269	71	residue	residue	NOUN
admet-854	269	72	glu174	glu174	PROPN
admet-854	269	73	by	by	ADP
admet-854	269	74	two	two	NUM
admet-854	269	75	salt	salt	NOUN
admet-854	269	76	bridge	bridge	NOUN
admet-854	269	77	(	(	PUNCT
admet-854	269	78	table	table	NOUN
admet-854	269	79	4	4	NUM
admet-854	269	80	)	)	PUNCT
admet-854	269	81	.	.	PUNCT
admet-854	270	1	table	table	NOUN
admet-854	270	2	3	3	NUM
admet-854	270	3	.	.	PUNCT
admet-854	271	1	the	the	DET
admet-854	271	2	energy	energy	NOUN
admet-854	271	3	binding	bind	VERB
admet-854	271	4	(	(	PUNCT
admet-854	271	5	δg	δg	VERB
admet-854	271	6	)	)	PUNCT
admet-854	271	7	and	and	CCONJ
admet-854	271	8	inhibition	inhibition	VERB
admet-854	271	9	constant	constant	ADJ
admet-854	271	10	(	(	PUNCT
admet-854	271	11	ki	ki	PROPN
admet-854	271	12	)	)	PUNCT
admet-854	271	13	of	of	ADP
admet-854	271	14	the	the	DET
admet-854	271	15	best	good	ADJ
admet-854	271	16	conformation	conformation	NOUN
admet-854	271	17	of	of	ADP
admet-854	271	18	the	the	DET
admet-854	271	19	complex	complex	ADJ
admet-854	271	20	nt5e	nt5e	NOUN
admet-854	271	21	amantadine	amantadine	NOUN
admet-854	271	22	and	and	CCONJ
admet-854	271	23	after	after	ADP
admet-854	271	24	redocking	redocke	VERB
admet-854	271	25	.	.	PUNCT
admet-854	272	1	pdb	pdb	PROPN
admet-854	273	1	i	i	NOUN
admet-854	273	2	d	d	PROPN
admet-854	273	3	amantadine	amantadine	NOUN
admet-854	273	4	redocking	redocke	VERB
admet-854	273	5	1	1	NUM
admet-854	273	6	δg	δg	PROPN
admet-854	273	7	(	(	PUNCT
admet-854	273	8	kcal	kcal	NOUN
admet-854	273	9	/	/	SYM
admet-854	273	10	mol	mol	NOUN
admet-854	273	11	)	)	PUNCT
admet-854	274	1	ki	ki	PROPN
admet-854	275	1	(	(	PUNCT
admet-854	275	2	μm	μm	INTJ
admet-854	275	3	)	)	PUNCT
admet-854	275	4	δg	δg	ADP
admet-854	275	5	(	(	PUNCT
admet-854	275	6	kcal	kcal	PROPN
admet-854	275	7	/	/	SYM
admet-854	275	8	mol	mol	NOUN
admet-854	275	9	)	)	PUNCT
admet-854	275	10	ki	ki	PROPN
admet-854	275	11	(	(	PUNCT
admet-854	275	12	μm	μm	NOUN
admet-854	275	13	)	)	PUNCT
admet-854	275	14	4h2i	4h2i	NOUN
admet-854	275	15	-8.08	-8.08	NUM
admet-854	275	16	1.2	1.2	NUM
admet-854	275	17	-4.91	-4.91	NUM
admet-854	275	18	250.92	250.92	NUM
admet-854	275	19	4h2f	4h2f	PROPN
admet-854	275	20	-7.93	-7.93	NUM
admet-854	275	21	1.55	1.55	NUM
admet-854	275	22	-6.95	-6.95	NUM
admet-854	275	23	8.01	8.01	NUM
admet-854	275	24	4h2	4h2	NOUN
admet-854	275	25	g	g	PROPN
admet-854	275	26	-7.59	-7.59	NUM
admet-854	275	27	2.72	2.72	NUM
admet-854	275	28	-5.97	-5.97	NOUN
admet-854	275	29	42.08	42.08	NUM
admet-854	275	30	4h1s	4h1s	NOUN
admet-854	275	31	-7.12	-7.12	NUM
admet-854	275	32	6.08	6.08	NUM
admet-854	275	33	-5.56	-5.56	NUM
admet-854	275	34	84.56	84.56	NUM
admet-854	275	35	1	1	NUM
admet-854	275	36	redocking	redocke	VERB
admet-854	275	37	with	with	ADP
admet-854	275	38	the	the	DET
admet-854	275	39	substrates	substrate	NOUN
admet-854	275	40	co	co	VERB
admet-854	275	41	-	-	VERB
admet-854	275	42	crystallized	crystallized	ADJ
admet-854	275	43	in	in	ADP
admet-854	275	44	pdb	pdb	PROPN
admet-854	275	45	x	x	PROPN
admet-854	275	46	-	-	NOUN
admet-854	275	47	ray	ray	NOUN
admet-854	275	48	3d	3d	PROPN
admet-854	275	49	structures	structure	NOUN
admet-854	275	50	.	.	PUNCT
admet-854	276	1	table	table	NOUN
admet-854	276	2	4	4	NUM
admet-854	276	3	.	.	PUNCT
admet-854	277	1	the	the	DET
admet-854	277	2	energy	energy	NOUN
admet-854	277	3	binding	bind	VERB
admet-854	277	4	(	(	PUNCT
admet-854	277	5	δg	δg	VERB
admet-854	277	6	)	)	PUNCT
admet-854	277	7	and	and	CCONJ
admet-854	277	8	inhibition	inhibition	VERB
admet-854	277	9	constant	constant	ADJ
admet-854	277	10	(	(	PUNCT
admet-854	277	11	ki	ki	PROPN
admet-854	277	12	)	)	PUNCT
admet-854	277	13	of	of	ADP
admet-854	277	14	the	the	DET
admet-854	277	15	best	good	ADJ
admet-854	277	16	conformation	conformation	NOUN
admet-854	277	17	of	of	ADP
admet-854	277	18	the	the	DET
admet-854	277	19	complex	complex	ADJ
admet-854	277	20	entpd1	entpd1	NOUN
admet-854	277	21	amantadine	amantadine	NOUN
admet-854	277	22	.	.	PUNCT
admet-854	278	1	pdb	pdb	PROPN
admet-854	279	1	i	i	NOUN
admet-854	279	2	d	d	PROPN
admet-854	279	3	amantadine	amantadine	NOUN
admet-854	279	4	redocking	redocke	VERB
admet-854	279	5	δg	δg	ADP
admet-854	279	6	(	(	PUNCT
admet-854	279	7	kcal	kcal	PROPN
admet-854	279	8	/	/	SYM
admet-854	279	9	mol	mol	NOUN
admet-854	279	10	)	)	PUNCT
admet-854	279	11	ki	ki	PROPN
admet-854	280	1	(	(	PUNCT
admet-854	280	2	μm	μm	NOUN
admet-854	280	3	)	)	PUNCT
admet-854	280	4	3zx0	3zx0	NUM
admet-854	280	5	-6.6	-6.6	NOUN
admet-854	280	6	14.56	14.56	NUM
admet-854	280	7	not	not	PART
admet-854	280	8	the	the	DET
admet-854	280	9	case	case	NOUN
admet-854	280	10	3zx2	3zx2	NUM
admet-854	280	11	-6.45	-6.45	NUM
admet-854	280	12	18.71	18.71	NUM
admet-854	280	13	3zx3	3zx3	NUM
admet-854	280	14	-7.24	-7.24	NUM
admet-854	280	15	4.94	4.94	NUM
admet-854	280	16	molecular	molecular	ADJ
admet-854	280	17	docking	docking	NOUN
admet-854	280	18	of	of	ADP
admet-854	280	19	the	the	DET
admet-854	280	20	human	human	ADJ
admet-854	280	21	nucleoside	nucleoside	PROPN
admet-854	280	22	diphosphate	diphosphate	PROPN
admet-854	280	23	kinase	kinase	PROPN
admet-854	280	24	3	3	NUM
admet-854	280	25	(	(	PUNCT
admet-854	280	26	ndk3	ndk3	PROPN
admet-854	280	27	)	)	PUNCT
admet-854	280	28	with	with	ADP
admet-854	280	29	ionized	ionized	ADJ
admet-854	280	30	amantadine	amantadine	NOUN
admet-854	280	31	and	and	CCONJ
admet-854	280	32	the	the	DET
admet-854	280	33	redocking	redocking	NOUN
admet-854	280	34	with	with	ADP
admet-854	280	35	the	the	DET
admet-854	280	36	substrates	substrate	NOUN
admet-854	280	37	the	the	DET
admet-854	280	38	nucleoside	nucleoside	NOUN
admet-854	280	39	diphosphate	diphosphate	PROPN
admet-854	280	40	kinase	kinase	PROPN
admet-854	280	41	3	3	NUM
admet-854	280	42	(	(	PUNCT
admet-854	280	43	ndk3	ndk3	PROPN
admet-854	280	44	)	)	PUNCT
admet-854	280	45	(	(	PUNCT
admet-854	280	46	e.c	e.c	PROPN
admet-854	280	47	.	.	NOUN
admet-854	280	48	2.7.4.6	2.7.4.6	NUM
admet-854	280	49	)	)	PUNCT
admet-854	280	50	catalysis	catalysis	NOUN
admet-854	280	51	the	the	DET
admet-854	280	52	reaction	reaction	NOUN
admet-854	280	53	:	:	PUNCT
admet-854	280	54	a	a	DET
admet-854	280	55	2’deoxyribonucleoside	2’deoxyribonucleoside	NUM
admet-854	280	56	5’-diphosphate	5’-diphosphate	NUM
admet-854	280	57	+	+	CCONJ
admet-854	280	58	atp	atp	NOUN
admet-854	280	59	=	=	PUNCT
admet-854	280	60	a	a	DET
admet-854	280	61	2’-deoxyribonucleoside	2’-deoxyribonucleoside	NUM
admet-854	280	62	5’-triphosphate	5’-triphosphate	NUM
admet-854	280	63	+	+	CCONJ
admet-854	280	64	adp	adp	PROPN
admet-854	280	65	.	.	PUNCT
admet-854	281	1	the	the	DET
admet-854	281	2	human	human	NOUN
admet-854	281	3	found	find	VERB
admet-854	281	4	in	in	ADP
admet-854	281	5	pdb	pdb	PROPN
admet-854	281	6	were	be	AUX
admet-854	281	7	analyzed	analyze	VERB
admet-854	281	8	about	about	ADP
admet-854	281	9	the	the	DET
admet-854	281	10	amantadine	amantadine	NOUN
admet-854	281	11	interactions	interaction	NOUN
admet-854	281	12	(	(	PUNCT
admet-854	281	13	table	table	NOUN
admet-854	281	14	5	5	NUM
admet-854	281	15	)	)	PUNCT
admet-854	281	16	.	.	PUNCT
admet-854	282	1	first	first	ADV
admet-854	282	2	,	,	PUNCT
admet-854	282	3	the	the	DET
admet-854	282	4	redock	redock	NOUN
admet-854	282	5	of	of	ADP
admet-854	282	6	the	the	DET
admet-854	282	7	substrates	substrate	NOUN
admet-854	282	8	co	co	VERB
admet-854	282	9	-	-	VERB
admet-854	282	10	crystallized	crystallized	ADJ
admet-854	282	11	in	in	ADP
admet-854	282	12	the	the	DET
admet-854	282	13	x	x	NOUN
admet-854	282	14	-	-	NOUN
admet-854	282	15	ray	ray	ADJ
admet-854	282	16	3d	3d	PROPN
admet-854	282	17	structures	structure	NOUN
admet-854	282	18	were	be	AUX
admet-854	282	19	made	make	VERB
admet-854	282	20	for	for	ADP
admet-854	282	21	three	three	NUM
admet-854	282	22	structures	structure	NOUN
admet-854	282	23	(	(	PUNCT
admet-854	282	24	pdb	pdb	NOUN
admet-854	282	25	id(s	id(s	PUNCT
admet-854	282	26	)	)	PUNCT
admet-854	282	27	1zs6	1zs6	NUM
admet-854	282	28	,	,	PUNCT
admet-854	282	29	2hvd	2hvd	NUM
admet-854	282	30	,	,	PUNCT
admet-854	282	31	and	and	CCONJ
admet-854	282	32	3bbb	3bbb	NUM
admet-854	282	33	)	)	PUNCT
admet-854	282	34	.	.	PUNCT
admet-854	283	1	in	in	ADP
admet-854	283	2	the	the	DET
admet-854	283	3	case	case	NOUN
admet-854	283	4	of	of	ADP
admet-854	283	5	1zs6	1zs6	NUM
admet-854	283	6	and	and	CCONJ
admet-854	283	7	3bbb	3bbb	NUM
admet-854	283	8	,	,	PUNCT
admet-854	283	9	no	no	DET
admet-854	283	10	significant	significant	ADJ
admet-854	283	11	interactions	interaction	NOUN
admet-854	283	12	of	of	ADP
admet-854	283	13	the	the	DET
admet-854	283	14	amantadine	amantadine	NOUN
admet-854	283	15	with	with	ADP
admet-854	283	16	atp	atp	NOUN
admet-854	283	17	-	-	PUNCT
admet-854	283	18	binding	bind	VERB
admet-854	283	19	residues	residue	NOUN
admet-854	283	20	or	or	CCONJ
admet-854	283	21	with	with	ADP
admet-854	283	22	the	the	DET
admet-854	283	23	histidine	histidine	NOUN
admet-854	283	24	from	from	ADP
admet-854	283	25	the	the	DET
admet-854	283	26	active	active	ADJ
admet-854	283	27	site	site	NOUN
admet-854	283	28	were	be	AUX
admet-854	283	29	observed	observe	VERB
admet-854	283	30	.	.	PUNCT
admet-854	284	1	the	the	DET
admet-854	284	2	2hvd	2hvd	NUM
admet-854	284	3	and	and	CCONJ
admet-854	284	4	1jxv	1jxv	NUM
admet-854	284	5	form	form	NOUN
admet-854	284	6	van	van	PROPN
admet-854	284	7	der	der	PROPN
admet-854	284	8	waal	waal	PROPN
admet-854	284	9	forces	force	NOUN
admet-854	284	10	with	with	ADP
admet-854	284	11	histidine	histidine	NOUN
admet-854	284	12	118	118	NUM
admet-854	284	13	from	from	ADP
admet-854	284	14	the	the	DET
admet-854	284	15	active	active	ADJ
admet-854	284	16	site	site	NOUN
admet-854	284	17	(	(	PUNCT
admet-854	284	18	pros	pro	NOUN
admet-854	284	19	-	-	PUNCT
admet-854	284	20	phosphohistidine	phosphohistidine	ADJ
admet-854	284	21	intermediate	intermediate	ADJ
admet-854	284	22	)	)	PUNCT
admet-854	284	23	but	but	CCONJ
admet-854	284	24	no	no	DET
admet-854	284	25	interactions	interaction	NOUN
admet-854	284	26	with	with	ADP
admet-854	284	27	the	the	DET
admet-854	284	28	atp	atp	NOUN
admet-854	284	29	-	-	PUNCT
admet-854	284	30	binding	bind	VERB
admet-854	284	31	residues	residue	NOUN
admet-854	284	32	.	.	PUNCT
admet-854	285	1	table	table	NOUN
admet-854	285	2	5	5	NUM
admet-854	285	3	.	.	PUNCT
admet-854	286	1	the	the	DET
admet-854	286	2	energy	energy	NOUN
admet-854	286	3	binding	bind	VERB
admet-854	286	4	(	(	PUNCT
admet-854	286	5	δg	δg	VERB
admet-854	286	6	)	)	PUNCT
admet-854	286	7	and	and	CCONJ
admet-854	286	8	inhibition	inhibition	VERB
admet-854	286	9	constant	constant	ADJ
admet-854	286	10	(	(	PUNCT
admet-854	286	11	ki	ki	PROPN
admet-854	286	12	)	)	PUNCT
admet-854	286	13	of	of	ADP
admet-854	286	14	the	the	DET
admet-854	286	15	best	good	ADJ
admet-854	286	16	conformation	conformation	NOUN
admet-854	286	17	of	of	ADP
admet-854	286	18	the	the	DET
admet-854	286	19	complex	complex	ADJ
admet-854	286	20	ndk3	ndk3	NOUN
admet-854	286	21	amantadine	amantadine	NOUN
admet-854	286	22	and	and	CCONJ
admet-854	286	23	after	after	ADP
admet-854	286	24	redocking	redocke	VERB
admet-854	286	25	.	.	PUNCT
admet-854	287	1	pdb	pdb	PROPN
admet-854	288	1	i	i	NOUN
admet-854	288	2	d	d	PROPN
admet-854	288	3	amantadine	amantadine	NOUN
admet-854	288	4	redocking	redocke	VERB
admet-854	288	5	1	1	NUM
admet-854	288	6	δg	δg	PROPN
admet-854	288	7	(	(	PUNCT
admet-854	288	8	kcal	kcal	NOUN
admet-854	288	9	/	/	SYM
admet-854	288	10	mol	mol	NOUN
admet-854	288	11	)	)	PUNCT
admet-854	289	1	ki	ki	PROPN
admet-854	290	1	(	(	PUNCT
admet-854	290	2	μm	μm	INTJ
admet-854	290	3	)	)	PUNCT
admet-854	290	4	δg	δg	ADP
admet-854	290	5	(	(	PUNCT
admet-854	290	6	kcal	kcal	PROPN
admet-854	290	7	/	/	SYM
admet-854	290	8	mol	mol	NOUN
admet-854	290	9	)	)	PUNCT
admet-854	290	10	ki	ki	PROPN
admet-854	290	11	(	(	PUNCT
admet-854	290	12	μm	μm	NUM
admet-854	290	13	)	)	PUNCT
admet-854	290	14	1zs6	1zs6	NUM
admet-854	290	15	-7.34	-7.34	NUM
admet-854	290	16	4.15	4.15	NUM
admet-854	290	17	-5.96	-5.96	NUM
admet-854	290	18	42.42	42.42	NUM
admet-854	290	19	2hvd	2hvd	NUM
admet-854	290	20	-6.55	-6.55	NUM
admet-854	290	21	15.69	15.69	NUM
admet-854	290	22	-5.81	-5.81	NUM
admet-854	290	23	54.99	54.99	NUM
admet-854	290	24	1jxv	1jxv	NUM
admet-854	290	25	-7.13	-7.13	NUM
admet-854	290	26	5.97	5.97	NUM
admet-854	290	27	not	not	PART
admet-854	290	28	the	the	DET
admet-854	290	29	case	case	NOUN
admet-854	290	30	3bbb	3bbb	NUM
admet-854	290	31	-5.63	-5.63	NUM
admet-854	290	32	74.71	74.71	NUM
admet-854	290	33	-5.88	-5.88	NUM
admet-854	290	34	2	2	NUM
admet-854	290	35	-5.35	-5.35	NUM
admet-854	290	36	3	3	NUM
admet-854	290	37	49.34	49.34	NUM
admet-854	290	38	2	2	NUM
admet-854	290	39	119.96	119.96	NUM
admet-854	290	40	3	3	NUM
admet-854	290	41	1	1	NUM
admet-854	290	42	redocking	redocke	VERB
admet-854	290	43	with	with	ADP
admet-854	290	44	the	the	DET
admet-854	290	45	substrates	substrate	NOUN
admet-854	290	46	co	co	VERB
admet-854	290	47	-	-	VERB
admet-854	290	48	crystallized	crystallized	ADJ
admet-854	290	49	in	in	ADP
admet-854	290	50	pdb	pdb	PROPN
admet-854	290	51	x	x	PROPN
admet-854	290	52	-	-	NOUN
admet-854	290	53	ray	ray	ADJ
admet-854	290	54	3d	3d	PROPN
admet-854	290	55	structures	structure	NOUN
admet-854	290	56	;	;	PUNCT
admet-854	290	57	2	2	NUM
admet-854	290	58	redock	redock	NOUN
admet-854	290	59	of	of	ADP
admet-854	290	60	2’-deoxyadenosine-5’monophosphate	2’-deoxyadenosine-5’monophosphate	NUM
admet-854	290	61	;	;	PUNCT
admet-854	290	62	3	3	NUM
admet-854	290	63	redock	redock	NOUN
admet-854	290	64	of	of	ADP
admet-854	290	65	2’-deoxyguanosine-5’-monophosphate	2’-deoxyguanosine-5’-monophosphate	NUM
admet-854	290	66	.	.	PUNCT
admet-854	291	1	molecular	molecular	ADJ
admet-854	291	2	docking	docking	NOUN
admet-854	291	3	of	of	ADP
admet-854	291	4	the	the	DET
admet-854	291	5	human	human	ADJ
admet-854	291	6	purine	purine	NOUN
admet-854	291	7	nucleoside	nucleoside	NOUN
admet-854	291	8	phosphorylase	phosphorylase	NOUN
admet-854	291	9	1	1	NUM
admet-854	291	10	(	(	PUNCT
admet-854	291	11	pnp1	pnp1	PROPN
admet-854	291	12	)	)	PUNCT
admet-854	291	13	with	with	ADP
admet-854	291	14	ionized	ionized	ADJ
admet-854	291	15	amantadine	amantadine	NOUN
admet-854	291	16	and	and	CCONJ
admet-854	291	17	the	the	DET
admet-854	291	18	redocking	redocking	NOUN
admet-854	291	19	with	with	ADP
admet-854	291	20	the	the	DET
admet-854	291	21	substrates	substrate	NOUN
admet-854	291	22	the	the	DET
admet-854	291	23	human	human	ADJ
admet-854	291	24	purine	purine	NOUN
admet-854	291	25	nucleoside	nucleoside	NOUN
admet-854	291	26	phosphorylase	phosphorylase	NOUN
admet-854	291	27	1	1	NUM
admet-854	291	28	(	(	PUNCT
admet-854	291	29	pnp1	pnp1	PROPN
admet-854	291	30	)	)	PUNCT
admet-854	291	31	(	(	PUNCT
admet-854	291	32	e.c	e.c	PROPN
admet-854	291	33	.	.	PROPN
admet-854	291	34	2.4.2.1	2.4.2.1	NUM
admet-854	291	35	)	)	PUNCT
admet-854	291	36	catalyses	catalyse	VERB
admet-854	291	37	the	the	DET
admet-854	291	38	reaction	reaction	NOUN
admet-854	291	39	:	:	PUNCT
admet-854	291	40	a	a	DET
admet-854	291	41	purine	purine	NOUN
admet-854	291	42	dhttp://dx.doi.org/10.5599/admet.854	dhttp://dx.doi.org/10.5599/admet.854	NOUN
admet-854	292	1	mihaela	mihaela	PROPN
admet-854	292	2	ileana	ileana	PROPN
admet-854	292	3	ionescu	ionescu	PROPN
admet-854	292	4	admet	admet	PROPN
admet-854	292	5	&	&	CCONJ
admet-854	292	6	dmpk	dmpk	PROPN
admet-854	292	7	8(2	8(2	NUM
admet-854	292	8	)	)	PUNCT
admet-854	292	9	(	(	PUNCT
admet-854	292	10	2020	2020	NUM
admet-854	292	11	)	)	PUNCT
admet-854	292	12	149	149	NUM
admet-854	292	13	-	-	SYM
admet-854	292	14	175	175	NUM
admet-854	292	15	166	166	NUM
admet-854	292	16	ribonucleotide	ribonucleotide	NOUN
admet-854	292	17	+	+	CCONJ
admet-854	292	18	phosphate	phosphate	NOUN
admet-854	292	19	=	=	PUNCT
admet-854	292	20	a	a	DET
admet-854	292	21	purine	purine	NOUN
admet-854	292	22	nucleobase	nucleobase	NOUN
admet-854	292	23	+	+	CCONJ
admet-854	292	24	alpha	alpha	NOUN
admet-854	292	25	-	-	PUNCT
admet-854	292	26	d	d	NOUN
admet-854	292	27	-	-	PUNCT
admet-854	292	28	ribose	ribose	ADJ
admet-854	292	29	1	1	NUM
admet-854	292	30	-	-	PUNCT
admet-854	292	31	phosphate	phosphate	NOUN
admet-854	292	32	.	.	PUNCT
admet-854	293	1	the	the	DET
admet-854	293	2	reaction	reaction	NOUN
admet-854	293	3	is	be	AUX
admet-854	293	4	part	part	NOUN
admet-854	293	5	of	of	ADP
admet-854	293	6	purine	purine	NOUN
admet-854	293	7	nucleoside	nucleoside	NOUN
admet-854	293	8	salvage	salvage	NOUN
admet-854	293	9	(	(	PUNCT
admet-854	293	10	uniprotkb	uniprotkb	ADJ
admet-854	293	11	p00491	p00491	NOUN
admet-854	293	12	)	)	PUNCT
admet-854	293	13	.	.	PUNCT
admet-854	294	1	the	the	DET
admet-854	294	2	human	human	PROPN
admet-854	294	3	pnp1s	pnp1s	PROPN
admet-854	294	4	retrieved	retrieve	VERB
admet-854	294	5	from	from	ADP
admet-854	294	6	the	the	DET
admet-854	294	7	pdb	pdb	NOUN
admet-854	294	8	were	be	AUX
admet-854	294	9	analyzed	analyze	VERB
admet-854	294	10	about	about	ADP
admet-854	294	11	the	the	DET
admet-854	294	12	amantadine	amantadine	NOUN
admet-854	294	13	interactions	interaction	NOUN
admet-854	294	14	(	(	PUNCT
admet-854	294	15	table	table	NOUN
admet-854	294	16	6	6	NUM
admet-854	294	17	)	)	PUNCT
admet-854	294	18	.	.	PUNCT
admet-854	295	1	the	the	DET
admet-854	295	2	molecular	molecular	ADJ
admet-854	295	3	docking	docking	NOUN
admet-854	295	4	of	of	ADP
admet-854	295	5	the	the	DET
admet-854	295	6	pnp1	pnp1	NOUN
admet-854	295	7	structures	structure	NOUN
admet-854	295	8	shows	show	VERB
admet-854	295	9	no	no	DET
admet-854	295	10	relevant	relevant	ADJ
admet-854	295	11	interactions	interaction	NOUN
admet-854	295	12	with	with	ADP
admet-854	295	13	amantadine	amantadine	NOUN
admet-854	295	14	.	.	PUNCT
admet-854	296	1	some	some	PRON
admet-854	296	2	of	of	ADP
admet-854	296	3	the	the	DET
admet-854	296	4	pnp1	pnp1	NOUN
admet-854	296	5	interact	interact	NOUN
admet-854	296	6	with	with	ADP
admet-854	296	7	amantadine	amantadine	NOUN
admet-854	296	8	with	with	ADP
admet-854	296	9	only	only	ADV
admet-854	296	10	one	one	NUM
admet-854	296	11	bindingsite	bindingsite	ADJ
admet-854	296	12	residue	residue	NOUN
admet-854	296	13	–	–	PUNCT
admet-854	296	14	the	the	DET
admet-854	296	15	1ulb	1ulb	NOUN
admet-854	296	16	interacts	interact	VERB
admet-854	296	17	with	with	ADP
admet-854	296	18	asn243	asn243	NOUN
admet-854	296	19	and	and	CCONJ
admet-854	296	20	the	the	DET
admet-854	296	21	1rfg	1rfg	PROPN
admet-854	296	22	forms	form	VERB
admet-854	296	23	a	a	DET
admet-854	296	24	salt	salt	NOUN
admet-854	296	25	bridge	bridge	NOUN
admet-854	296	26	with	with	ADP
admet-854	296	27	glu201	glu201	PROPN
admet-854	296	28	.	.	PUNCT
admet-854	297	1	the	the	DET
admet-854	297	2	2a0w	2a0w	ADJ
admet-854	297	3	,	,	PUNCT
admet-854	297	4	2a0x	2a0x	NUM
admet-854	297	5	,	,	PUNCT
admet-854	297	6	2a0y	2a0y	NUM
admet-854	297	7	,	,	PUNCT
admet-854	297	8	1rsz	1rsz	NUM
admet-854	297	9	form	form	NOUN
admet-854	297	10	van	van	PROPN
admet-854	297	11	der	der	NOUN
admet-854	297	12	waals	waal	NOUN
admet-854	297	13	interactions	interaction	NOUN
admet-854	297	14	with	with	ADP
admet-854	297	15	only	only	ADV
admet-854	297	16	one	one	NUM
admet-854	297	17	binding	binding	ADJ
admet-854	297	18	-	-	PUNCT
admet-854	297	19	site	site	NOUN
admet-854	297	20	residue	residue	NOUN
admet-854	297	21	gln201	gln201	VERB
admet-854	297	22	.	.	PUNCT
admet-854	297	23	table	table	NOUN
admet-854	297	24	6	6	NUM
admet-854	297	25	.	.	PUNCT
admet-854	298	1	the	the	DET
admet-854	298	2	energy	energy	NOUN
admet-854	298	3	binding	bind	VERB
admet-854	298	4	(	(	PUNCT
admet-854	298	5	δg	δg	VERB
admet-854	298	6	)	)	PUNCT
admet-854	298	7	and	and	CCONJ
admet-854	298	8	inhibition	inhibition	VERB
admet-854	298	9	constant	constant	ADJ
admet-854	298	10	(	(	PUNCT
admet-854	298	11	ki	ki	PROPN
admet-854	298	12	)	)	PUNCT
admet-854	298	13	of	of	ADP
admet-854	298	14	the	the	DET
admet-854	298	15	best	good	ADJ
admet-854	298	16	conformation	conformation	NOUN
admet-854	298	17	of	of	ADP
admet-854	298	18	the	the	DET
admet-854	298	19	complex	complex	ADJ
admet-854	298	20	pnp1	pnp1	NOUN
admet-854	298	21	amantadine	amantadine	NOUN
admet-854	298	22	and	and	CCONJ
admet-854	298	23	after	after	ADP
admet-854	298	24	redocking	redocke	VERB
admet-854	298	25	.	.	PUNCT
admet-854	299	1	pdb	pdb	PROPN
admet-854	300	1	i	i	NOUN
admet-854	300	2	d	d	PROPN
admet-854	300	3	amantadine	amantadine	NOUN
admet-854	300	4	redocking	redocke	VERB
admet-854	300	5	1	1	NUM
admet-854	300	6	δg	δg	PROPN
admet-854	300	7	(	(	PUNCT
admet-854	300	8	kcal	kcal	NOUN
admet-854	300	9	/	/	SYM
admet-854	300	10	mol	mol	NOUN
admet-854	300	11	)	)	PUNCT
admet-854	301	1	ki	ki	PROPN
admet-854	302	1	(	(	PUNCT
admet-854	302	2	μm	μm	INTJ
admet-854	302	3	)	)	PUNCT
admet-854	302	4	δg	δg	ADP
admet-854	302	5	(	(	PUNCT
admet-854	302	6	kcal	kcal	PROPN
admet-854	302	7	/	/	SYM
admet-854	302	8	mol	mol	NOUN
admet-854	302	9	)	)	PUNCT
admet-854	302	10	ki	ki	PROPN
admet-854	303	1	1ula	1ula	NUM
admet-854	303	2	-7.31	-7.31	NOUN
admet-854	303	3	4.35	4.35	NUM
admet-854	303	4	not	not	PART
admet-854	303	5	the	the	DET
admet-854	303	6	case	case	NOUN
admet-854	303	7	1ulb	1ulb	NOUN
admet-854	303	8	-6.74	-6.74	NUM
admet-854	303	9	11.47	11.47	NUM
admet-854	303	10	-5.61	-5.61	NUM
admet-854	303	11	77.85	77.85	NUM
admet-854	303	12	μm	μm	NOUN
admet-854	303	13	2a0w	2a0w	ADJ
admet-854	303	14	-6.52	-6.52	ADJ
admet-854	303	15	16.57	16.57	NUM
admet-854	303	16	-8.63	-8.63	NUM
admet-854	303	17	473.78	473.78	NUM
admet-854	303	18	nm	nm	NOUN
admet-854	303	19	2a0x	2a0x	NUM
admet-854	303	20	-6.5	-6.5	NOUN
admet-854	303	21	17.29	17.29	NUM
admet-854	303	22	-8.69	-8.69	NUM
admet-854	303	23	425.71	425.71	NUM
admet-854	303	24	nm	nm	NOUN
admet-854	303	25	2a0y	2a0y	NUM
admet-854	303	26	-6.46	-6.46	NUM
admet-854	303	27	18.38	18.38	NUM
admet-854	303	28	-8.89	-8.89	NUM
admet-854	303	29	306.03	306.03	NUM
admet-854	303	30	nm	nm	NOUN
admet-854	303	31	1rsz	1rsz	PROPN
admet-854	303	32	-6.41	-6.41	VERB
admet-854	303	33	19.92	19.92	NUM
admet-854	303	34	-8.35	-8.35	NUM
admet-854	303	35	760.14	760.14	NUM
admet-854	303	36	nm	nm	DET
admet-854	303	37	1rfg	1rfg	PROPN
admet-854	303	38	-6.4	-6.4	PROPN
admet-854	303	39	20.45	20.45	NUM
admet-854	303	40	-7.42	-7.42	NUM
admet-854	303	41	3.67	3.67	NUM
admet-854	303	42	μm	μm	NUM
admet-854	303	43	1	1	NUM
admet-854	303	44	redocking	redocke	VERB
admet-854	303	45	with	with	ADP
admet-854	303	46	the	the	DET
admet-854	303	47	substrates	substrate	NOUN
admet-854	303	48	co	co	VERB
admet-854	303	49	-	-	VERB
admet-854	303	50	crystallized	crystallized	ADJ
admet-854	303	51	in	in	ADP
admet-854	303	52	pdb	pdb	PROPN
admet-854	303	53	x	x	PROPN
admet-854	303	54	-	-	NOUN
admet-854	303	55	ray	ray	NOUN
admet-854	303	56	3d	3d	PROPN
admet-854	303	57	structures	structure	NOUN
admet-854	303	58	.	.	PUNCT
admet-854	304	1	molecular	molecular	ADJ
admet-854	304	2	docking	docking	NOUN
admet-854	304	3	of	of	ADP
admet-854	304	4	the	the	DET
admet-854	304	5	creatine	creatine	NOUN
admet-854	304	6	kinases	kinase	NOUN
admet-854	304	7	(	(	PUNCT
admet-854	304	8	cks	ck	NOUN
admet-854	304	9	)	)	PUNCT
admet-854	304	10	with	with	ADP
admet-854	304	11	ionized	ionized	ADJ
admet-854	304	12	amantadine	amantadine	NOUN
admet-854	304	13	and	and	CCONJ
admet-854	304	14	redocking	redocke	VERB
admet-854	304	15	the	the	DET
admet-854	304	16	ck	ck	PROPN
admet-854	304	17	(	(	PUNCT
admet-854	304	18	e.c	e.c	PROPN
admet-854	304	19	.	.	PROPN
admet-854	304	20	2.7.3.2	2.7.3.2	NUM
admet-854	304	21	)	)	PUNCT
admet-854	304	22	catalyses	catalyse	VERB
admet-854	304	23	the	the	DET
admet-854	304	24	reversible	reversible	ADJ
admet-854	304	25	reaction	reaction	NOUN
admet-854	304	26	:	:	PUNCT
admet-854	304	27	atp	atp	PROPN
admet-854	304	28	+	+	CCONJ
admet-854	304	29	creatine	creatine	NOUN
admet-854	304	30	=	=	SYM
admet-854	304	31	adp	adp	PROPN
admet-854	305	1	+	+	NUM
admet-854	305	2	h	h	NOUN
admet-854	305	3	+	+	CCONJ
admet-854	305	4	+	+	CCONJ
admet-854	305	5	n	n	CCONJ
admet-854	305	6	-	-	PUNCT
admet-854	305	7	phosphocreatine	phosphocreatine	NOUN
admet-854	305	8	.	.	PUNCT
admet-854	306	1	the	the	DET
admet-854	306	2	different	different	ADJ
admet-854	306	3	cks	ck	NOUN
admet-854	306	4	type	type	NOUN
admet-854	306	5	(	(	PUNCT
admet-854	306	6	uniprotkb	uniprotkb	NOUN
admet-854	306	7	p11009	p11009	PROPN
admet-854	306	8	,	,	PUNCT
admet-854	306	9	p17540	p17540	PROPN
admet-854	306	10	,	,	PUNCT
admet-854	306	11	p00563	p00563	PROPN
admet-854	306	12	,	,	PUNCT
admet-854	306	13	p06732	p06732	PROPN
admet-854	306	14	,	,	PUNCT
admet-854	306	15	p12277	p12277	NOUN
admet-854	306	16	,	,	PUNCT
admet-854	306	17	p05122	p05122	PROPN
admet-854	306	18	,	,	PUNCT
admet-854	306	19	and	and	CCONJ
admet-854	306	20	q9xsc6	q9xsc6	NUM
admet-854	306	21	)	)	PUNCT
admet-854	306	22	retieved	retieve	VERB
admet-854	306	23	form	form	NOUN
admet-854	306	24	the	the	DET
admet-854	306	25	pdb	pdb	PROPN
admet-854	306	26	were	be	AUX
admet-854	306	27	analysed	analyse	VERB
admet-854	306	28	about	about	ADP
admet-854	306	29	the	the	DET
admet-854	306	30	amantadine	amantadine	NOUN
admet-854	306	31	interactions	interaction	NOUN
admet-854	306	32	(	(	PUNCT
admet-854	306	33	table	table	NOUN
admet-854	306	34	7	7	NUM
admet-854	306	35	)	)	PUNCT
admet-854	306	36	.	.	PUNCT
admet-854	307	1	molecular	molecular	ADJ
admet-854	307	2	docking	docking	NOUN
admet-854	307	3	results	result	NOUN
admet-854	307	4	show	show	VERB
admet-854	307	5	no	no	DET
admet-854	307	6	interactions	interaction	NOUN
admet-854	307	7	of	of	ADP
admet-854	307	8	amantadine	amantadine	NOUN
admet-854	307	9	with	with	ADP
admet-854	307	10	atp	atp	NOUN
admet-854	307	11	-	-	PUNCT
admet-854	307	12	binding	bind	VERB
admet-854	307	13	residues	residue	NOUN
admet-854	307	14	or	or	CCONJ
admet-854	307	15	nucleotide	nucleotide	NOUN
admet-854	307	16	(	(	PUNCT
admet-854	307	17	atp	atp	NOUN
admet-854	307	18	)	)	PUNCT
admet-854	307	19	binding	bind	VERB
admet-854	307	20	regions	region	NOUN
admet-854	307	21	.	.	PUNCT
admet-854	308	1	table	table	NOUN
admet-854	308	2	7	7	NUM
admet-854	308	3	.	.	PUNCT
admet-854	309	1	the	the	DET
admet-854	309	2	energy	energy	NOUN
admet-854	309	3	binding	bind	VERB
admet-854	309	4	(	(	PUNCT
admet-854	309	5	δg	δg	VERB
admet-854	309	6	)	)	PUNCT
admet-854	309	7	and	and	CCONJ
admet-854	309	8	inhibition	inhibition	VERB
admet-854	309	9	constant	constant	ADJ
admet-854	309	10	(	(	PUNCT
admet-854	309	11	ki	ki	PROPN
admet-854	309	12	)	)	PUNCT
admet-854	309	13	of	of	ADP
admet-854	309	14	the	the	DET
admet-854	309	15	best	good	ADJ
admet-854	309	16	conformation	conformation	NOUN
admet-854	309	17	of	of	ADP
admet-854	309	18	the	the	DET
admet-854	309	19	complex	complex	ADJ
admet-854	309	20	ck	ck	PRON
admet-854	309	21	amantadine	amantadine	NOUN
admet-854	309	22	and	and	CCONJ
admet-854	309	23	after	after	ADP
admet-854	309	24	redocking	redocke	VERB
admet-854	309	25	.	.	PUNCT
admet-854	310	1	pdb	pdb	PROPN
admet-854	311	1	i	i	NOUN
admet-854	311	2	d	d	PROPN
admet-854	311	3	amantadine	amantadine	NOUN
admet-854	311	4	redocking	redocke	VERB
admet-854	311	5	1	1	NUM
admet-854	311	6	δg	δg	PROPN
admet-854	311	7	(	(	PUNCT
admet-854	311	8	kcal	kcal	NOUN
admet-854	311	9	/	/	SYM
admet-854	311	10	mol	mol	NOUN
admet-854	311	11	)	)	PUNCT
admet-854	311	12	ki	ki	PROPN
admet-854	312	1	δg	δg	ADP
admet-854	312	2	(	(	PUNCT
admet-854	312	3	kcal	kcal	PROPN
admet-854	312	4	/	/	SYM
admet-854	312	5	mol	mol	NOUN
admet-854	312	6	)	)	PUNCT
admet-854	312	7	ki	ki	PROPN
admet-854	312	8	mitochondrial	mitochondrial	ADJ
admet-854	312	9	ck	ck	PROPN
admet-854	312	10	1crk	1crk	NUM
admet-854	312	11	-6.65	-6.65	NUM
admet-854	312	12	13.26	13.26	NUM
admet-854	312	13	μm	μm	NUM
admet-854	312	14	not	not	PART
admet-854	312	15	the	the	DET
admet-854	312	16	case	case	NOUN
admet-854	312	17	4z9	4z9	NOUN
admet-854	312	18	m	m	NOUN
admet-854	312	19	-7.3	-7.3	ADJ
admet-854	312	20	4.49	4.49	NUM
admet-854	312	21	μm	μm	NUM
admet-854	312	22	-8.64	-8.64	NUM
admet-854	312	23	462.56	462.56	NUM
admet-854	312	24	nm	nm	DET
admet-854	312	25	muscle	muscle	NOUN
admet-854	312	26	ck	ck	INTJ
admet-854	312	27	2crk	2crk	NUM
admet-854	312	28	-7.65	-7.65	NUM
admet-854	312	29	2.45	2.45	NUM
admet-854	312	30	μm	μm	NOUN
admet-854	312	31	not	not	PART
admet-854	312	32	the	the	DET
admet-854	312	33	case	case	NOUN
admet-854	312	34	1ioe	1ioe	NOUN
admet-854	312	35	-5.81	-5.81	NOUN
admet-854	312	36	54.93	54.93	NUM
admet-854	312	37	μm	μm	NOUN
admet-854	312	38	not	not	PART
admet-854	312	39	the	the	DET
admet-854	312	40	case	case	NOUN
admet-854	312	41	1u6r	1u6r	NUM
admet-854	312	42	-6.37	-6.37	NUM
admet-854	312	43	21.24	21.24	NUM
admet-854	312	44	μm	μm	NOUN
admet-854	312	45	-7.84	-7.84	NOUN
admet-854	312	46	1.78	1.78	NUM
admet-854	312	47	μm	μm	NUM
admet-854	312	48	brain	brain	NOUN
admet-854	312	49	ck	ck	ADP
admet-854	313	1	3drb	3drb	NUM
admet-854	313	2	-6.39	-6.39	NUM
admet-854	313	3	20.63	20.63	NUM
admet-854	313	4	μm	μm	NOUN
admet-854	313	5	not	not	PART
admet-854	313	6	the	the	DET
admet-854	313	7	case	case	NOUN
admet-854	313	8	3dre	3dre	NOUN
admet-854	313	9	-6.99	-6.99	NOUN
admet-854	313	10	7.57	7.57	NUM
admet-854	313	11	μm	μm	NOUN
admet-854	313	12	not	not	PART
admet-854	313	13	the	the	DET
admet-854	313	14	case	case	NOUN
admet-854	313	15	1qh4	1qh4	NUM
admet-854	313	16	-7.45	-7.45	NUM
admet-854	313	17	3.44	3.44	NUM
admet-854	313	18	μm	μm	NOUN
admet-854	313	19	not	not	PART
admet-854	313	20	the	the	DET
admet-854	313	21	case	case	NOUN
admet-854	313	22	retinal	retinal	ADJ
admet-854	313	23	ck	ck	PROPN
admet-854	313	24	1g0w	1g0w	NUM
admet-854	313	25	-7.12	-7.12	NUM
admet-854	313	26	6.07	6.07	NUM
admet-854	313	27	μm	μm	NOUN
admet-854	313	28	not	not	PART
admet-854	313	29	the	the	DET
admet-854	313	30	case	case	NOUN
admet-854	313	31	1	1	NUM
admet-854	313	32	redocking	redocke	VERB
admet-854	313	33	with	with	ADP
admet-854	313	34	the	the	DET
admet-854	313	35	substrates	substrate	NOUN
admet-854	313	36	co	co	VERB
admet-854	313	37	-	-	VERB
admet-854	313	38	crystallized	crystallized	ADJ
admet-854	313	39	in	in	ADP
admet-854	313	40	pdb	pdb	PROPN
admet-854	313	41	x	x	PROPN
admet-854	313	42	-	-	NOUN
admet-854	313	43	ray	ray	NOUN
admet-854	313	44	3d	3d	PROPN
admet-854	313	45	structures	structure	NOUN
admet-854	313	46	.	.	PUNCT
admet-854	314	1	discussion	discussion	NOUN
admet-854	314	2	the	the	DET
admet-854	314	3	pd	pd	PROPN
admet-854	314	4	is	be	AUX
admet-854	314	5	an	an	DET
admet-854	314	6	idiopathic	idiopathic	ADJ
admet-854	314	7	,	,	PUNCT
admet-854	314	8	progressive	progressive	ADJ
admet-854	314	9	disease	disease	NOUN
admet-854	314	10	of	of	ADP
admet-854	314	11	the	the	DET
admet-854	314	12	central	central	ADJ
admet-854	314	13	neurological	neurological	ADJ
admet-854	314	14	system	system	NOUN
admet-854	314	15	.	.	PUNCT
admet-854	315	1	the	the	DET
admet-854	315	2	treatment	treatment	NOUN
admet-854	315	3	of	of	ADP
admet-854	315	4	dyskinesia	dyskinesia	NOUN
admet-854	315	5	remains	remain	VERB
admet-854	315	6	a	a	DET
admet-854	315	7	critical	critical	ADJ
admet-854	315	8	issue	issue	NOUN
admet-854	315	9	in	in	ADP
admet-854	315	10	the	the	DET
admet-854	315	11	pd	pd	PROPN
admet-854	315	12	treatment	treatment	NOUN
admet-854	315	13	strategy	strategy	NOUN
admet-854	315	14	,	,	PUNCT
admet-854	315	15	levodopa	levodopa	NOUN
admet-854	315	16	-	-	PUNCT
admet-854	315	17	induced	induce	VERB
admet-854	315	18	dyskinesia	dyskinesia	NOUN
admet-854	315	19	being	be	AUX
admet-854	315	20	a	a	DET
admet-854	315	21	real	real	ADJ
admet-854	315	22	challenge	challenge	NOUN
admet-854	315	23	for	for	ADP
admet-854	315	24	both	both	DET
admet-854	315	25	patients	patient	NOUN
admet-854	315	26	and	and	CCONJ
admet-854	315	27	healthcare	healthcare	NOUN
admet-854	315	28	professionals	professional	NOUN
admet-854	315	29	.	.	PUNCT
admet-854	316	1	the	the	DET
admet-854	316	2	combination	combination	NOUN
admet-854	316	3	of	of	ADP
admet-854	316	4	levodopa	levodopa	NOUN
admet-854	316	5	amantadine	amantadine	NOUN
admet-854	316	6	is	be	AUX
admet-854	316	7	useful	useful	ADJ
admet-854	316	8	for	for	ADP
admet-854	316	9	the	the	DET
admet-854	316	10	people	people	NOUN
admet-854	316	11	who	who	PRON
admet-854	316	12	do	do	AUX
admet-854	316	13	not	not	PART
admet-854	316	14	tolerate	tolerate	VERB
admet-854	316	15	optimal	optimal	ADJ
admet-854	316	16	doses	dose	NOUN
admet-854	316	17	of	of	ADP
admet-854	316	18	levodopa	levodopa	NOUN
admet-854	316	19	and	and	CCONJ
admet-854	316	20	allows	allow	VERB
admet-854	316	21	better	well	ADJ
admet-854	316	22	control	control	NOUN
admet-854	316	23	of	of	ADP
admet-854	316	24	the	the	DET
admet-854	316	25	admet	admet	PROPN
admet-854	316	26	&	&	CCONJ
admet-854	316	27	dmpk	dmpk	PROPN
admet-854	316	28	8(2	8(2	NUM
admet-854	316	29	)	)	PUNCT
admet-854	316	30	(	(	PUNCT
admet-854	316	31	2020	2020	NUM
admet-854	316	32	)	)	PUNCT
admet-854	316	33	149	149	NUM
admet-854	316	34	-	-	SYM
admet-854	316	35	175	175	NUM
admet-854	316	36	amantadine	amantadine	NOUN
admet-854	316	37	binding	bind	VERB
admet-854	316	38	to	to	ADP
admet-854	316	39	the	the	DET
admet-854	316	40	enzymes	enzyme	NOUN
admet-854	316	41	regulated	regulate	VERB
admet-854	316	42	in	in	ADP
admet-854	316	43	parkinson	parkinson	NOUN
admet-854	316	44	’s	’s	PART
admet-854	316	45	disease	disease	NOUN
admet-854	316	46	doi	doi	PROPN
admet-854	316	47	:	:	PUNCT
admet-854	316	48	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	316	49	167	167	NUM
admet-854	316	50	disease	disease	NOUN
admet-854	316	51	.	.	PUNCT
admet-854	317	1	among	among	ADP
admet-854	317	2	other	other	ADJ
admet-854	317	3	biomarkers	biomarker	NOUN
admet-854	317	4	modified	modify	VERB
admet-854	317	5	in	in	ADP
admet-854	317	6	pd	pd	PROPN
admet-854	317	7	,	,	PUNCT
admet-854	317	8	there	there	PRON
admet-854	317	9	is	be	VERB
admet-854	317	10	a	a	DET
admet-854	317	11	dysregulation	dysregulation	NOUN
admet-854	317	12	of	of	ADP
admet-854	317	13	some	some	DET
admet-854	317	14	human	human	PROPN
admet-854	317	15	ak	ak	PROPN
admet-854	317	16	isoforms	isoform	NOUN
admet-854	317	17	that	that	PRON
admet-854	317	18	are	be	AUX
admet-854	317	19	also	also	ADV
admet-854	317	20	altered	alter	VERB
admet-854	317	21	in	in	ADP
admet-854	317	22	other	other	ADJ
admet-854	317	23	muscle	muscle	NOUN
admet-854	317	24	diseases	disease	NOUN
admet-854	317	25	.	.	PUNCT
admet-854	318	1	the	the	DET
admet-854	318	2	ak1	ak1	NOUN
admet-854	318	3	and	and	CCONJ
admet-854	318	4	ak2	ak2	NOUN
admet-854	318	5	isoforms	isoform	NOUN
admet-854	318	6	are	be	AUX
admet-854	318	7	also	also	ADV
admet-854	318	8	involved	involve	VERB
admet-854	318	9	in	in	ADP
admet-854	318	10	modulation	modulation	NOUN
admet-854	318	11	immunity	immunity	NOUN
admet-854	318	12	and	and	CCONJ
admet-854	318	13	inflammation	inflammation	NOUN
admet-854	318	14	in	in	ADP
admet-854	318	15	many	many	ADJ
admet-854	318	16	diseases	disease	NOUN
admet-854	318	17	.	.	PUNCT
admet-854	319	1	these	these	DET
admet-854	319	2	observations	observation	NOUN
admet-854	319	3	formed	form	VERB
admet-854	319	4	the	the	DET
admet-854	319	5	basis	basis	NOUN
admet-854	319	6	of	of	ADP
admet-854	319	7	the	the	DET
admet-854	319	8	design	design	NOUN
admet-854	319	9	of	of	ADP
admet-854	319	10	this	this	DET
admet-854	319	11	study	study	NOUN
admet-854	319	12	.	.	PUNCT
admet-854	320	1	because	because	SCONJ
admet-854	320	2	ak	ak	PROPN
admet-854	320	3	is	be	AUX
admet-854	320	4	an	an	DET
admet-854	320	5	important	important	ADJ
admet-854	320	6	enzyme	enzyme	NOUN
admet-854	320	7	for	for	ADP
admet-854	320	8	energetic	energetic	ADJ
admet-854	320	9	metabolism	metabolism	NOUN
admet-854	320	10	,	,	PUNCT
admet-854	320	11	its	its	PRON
admet-854	320	12	involvement	involvement	NOUN
admet-854	320	13	in	in	ADP
admet-854	320	14	a	a	DET
admet-854	320	15	variety	variety	NOUN
admet-854	320	16	of	of	ADP
admet-854	320	17	diseases	disease	NOUN
admet-854	320	18	is	be	AUX
admet-854	320	19	not	not	PART
admet-854	320	20	surprising	surprising	ADJ
admet-854	320	21	.	.	PUNCT
admet-854	321	1	because	because	SCONJ
admet-854	321	2	the	the	DET
admet-854	321	3	atp	atp	NOUN
admet-854	321	4	is	be	AUX
admet-854	321	5	the	the	DET
admet-854	321	6	most	most	ADV
admet-854	321	7	used	used	ADJ
admet-854	321	8	“	"	PUNCT
admet-854	321	9	exchange	exchange	NOUN
admet-854	321	10	currency	currency	NOUN
admet-854	321	11	”	"	PUNCT
admet-854	321	12	in	in	ADP
admet-854	321	13	nature	nature	NOUN
admet-854	321	14	,	,	PUNCT
admet-854	321	15	the	the	DET
admet-854	321	16	crucial	crucial	ADJ
admet-854	321	17	role	role	NOUN
admet-854	321	18	of	of	ADP
admet-854	321	19	ak	ak	PROPN
admet-854	321	20	is	be	AUX
admet-854	321	21	energetic	energetic	ADJ
admet-854	321	22	metabolism	metabolism	NOUN
admet-854	321	23	explains	explain	VERB
admet-854	321	24	the	the	DET
admet-854	321	25	interest	interest	NOUN
admet-854	321	26	in	in	ADP
admet-854	321	27	the	the	DET
admet-854	321	28	study	study	NOUN
admet-854	321	29	of	of	ADP
admet-854	321	30	this	this	DET
admet-854	321	31	enzyme	enzyme	NOUN
admet-854	321	32	.	.	PUNCT
admet-854	322	1	nine	nine	NUM
admet-854	322	2	human	human	ADJ
admet-854	322	3	aks	ak	NOUN
admet-854	322	4	isoforms	isoform	NOUN
admet-854	322	5	have	have	AUX
admet-854	322	6	been	be	AUX
admet-854	322	7	identified	identify	VERB
admet-854	322	8	,	,	PUNCT
admet-854	322	9	each	each	PRON
admet-854	322	10	with	with	ADP
admet-854	322	11	important	important	ADJ
admet-854	322	12	characteristics	characteristic	NOUN
admet-854	322	13	that	that	PRON
admet-854	322	14	differentiate	differentiate	VERB
admet-854	322	15	them	they	PRON
admet-854	322	16	[	[	X
admet-854	322	17	60	60	NUM
admet-854	322	18	]	]	PUNCT
admet-854	322	19	.	.	PUNCT
admet-854	323	1	five	five	NUM
admet-854	323	2	aks	ak	NOUN
admet-854	323	3	isoforms	isoform	NOUN
admet-854	323	4	have	have	VERB
admet-854	323	5	the	the	DET
admet-854	323	6	x	x	ADJ
admet-854	323	7	-	-	NOUN
admet-854	323	8	ray	ray	NOUN
admet-854	323	9	structure	structure	NOUN
admet-854	323	10	deposited	deposit	VERB
admet-854	323	11	in	in	ADP
admet-854	323	12	public	public	ADJ
admet-854	323	13	databases	database	NOUN
admet-854	323	14	but	but	CCONJ
admet-854	323	15	only	only	ADV
admet-854	323	16	four	four	NUM
admet-854	323	17	isoforms	isoform	NOUN
admet-854	323	18	are	be	AUX
admet-854	323	19	in	in	ADP
admet-854	323	20	closed	closed	ADJ
admet-854	323	21	-	-	PUNCT
admet-854	323	22	conformation	conformation	NOUN
admet-854	323	23	(	(	PUNCT
admet-854	323	24	ak1	ak1	PROPN
admet-854	323	25	,	,	PUNCT
admet-854	323	26	ak2	ak2	NOUN
admet-854	323	27	,	,	PUNCT
admet-854	323	28	ak4	ak4	NOUN
admet-854	323	29	,	,	PUNCT
admet-854	323	30	and	and	CCONJ
admet-854	323	31	ak5	ak5	ADJ
admet-854	323	32	)	)	PUNCT
admet-854	323	33	.	.	PUNCT
admet-854	324	1	consequently	consequently	ADV
admet-854	324	2	,	,	PUNCT
admet-854	324	3	only	only	ADV
admet-854	324	4	the	the	DET
admet-854	324	5	aks	ak	NOUN
admet-854	324	6	in	in	ADP
admet-854	324	7	closed	closed	ADJ
admet-854	324	8	-	-	PUNCT
admet-854	324	9	conformation	conformation	NOUN
admet-854	324	10	were	be	AUX
admet-854	324	11	selected	select	VERB
admet-854	324	12	for	for	ADP
admet-854	324	13	the	the	DET
admet-854	324	14	present	present	ADJ
admet-854	324	15	study	study	NOUN
admet-854	324	16	–	–	PUNCT
admet-854	324	17	five	five	NUM
admet-854	324	18	human	human	ADJ
admet-854	324	19	aks	ak	NOUN
admet-854	324	20	,	,	PUNCT
admet-854	324	21	one	one	NUM
admet-854	324	22	ak1	ak1	ADV
admet-854	324	23	from	from	ADP
admet-854	324	24	zebrafish	zebrafish	NUM
admet-854	324	25	,	,	PUNCT
admet-854	324	26	and	and	CCONJ
admet-854	324	27	two	two	NUM
admet-854	324	28	bacterial	bacterial	ADJ
admet-854	324	29	aks	ak	NOUN
admet-854	324	30	.	.	PUNCT
admet-854	325	1	experimental	experimental	ADJ
admet-854	325	2	studies	study	NOUN
admet-854	325	3	are	be	AUX
admet-854	325	4	very	very	ADV
admet-854	325	5	often	often	ADV
admet-854	325	6	costly	costly	ADJ
admet-854	325	7	and	and	CCONJ
admet-854	325	8	time	time	NOUN
admet-854	325	9	-	-	PUNCT
admet-854	325	10	consuming	consume	VERB
admet-854	325	11	,	,	PUNCT
admet-854	325	12	so	so	ADV
admet-854	325	13	conducting	conduct	VERB
admet-854	325	14	an	an	DET
admet-854	325	15	experimental	experimental	ADJ
admet-854	325	16	study	study	NOUN
admet-854	325	17	without	without	ADP
admet-854	325	18	strong	strong	ADJ
admet-854	325	19	theoretical	theoretical	ADJ
admet-854	325	20	research	research	NOUN
admet-854	325	21	is	be	AUX
admet-854	325	22	not	not	PART
admet-854	325	23	a	a	DET
admet-854	325	24	pragmatic	pragmatic	ADJ
admet-854	325	25	approach	approach	NOUN
admet-854	325	26	.	.	PUNCT
admet-854	326	1	molecular	molecular	ADJ
admet-854	326	2	docking	docking	NOUN
admet-854	326	3	is	be	AUX
admet-854	326	4	a	a	DET
admet-854	326	5	useful	useful	ADJ
admet-854	326	6	method	method	NOUN
admet-854	326	7	for	for	ADP
admet-854	326	8	first	first	ADJ
admet-854	326	9	analyzes	analyze	NOUN
admet-854	326	10	of	of	ADP
admet-854	326	11	new	new	ADJ
admet-854	326	12	protein	protein	NOUN
admet-854	326	13	-	-	PUNCT
admet-854	326	14	ligand	ligand	NOUN
admet-854	326	15	interaction	interaction	NOUN
admet-854	326	16	.	.	PUNCT
admet-854	327	1	this	this	DET
admet-854	327	2	method	method	NOUN
admet-854	327	3	allowed	allow	VERB
admet-854	327	4	analysis	analysis	NOUN
admet-854	327	5	of	of	ADP
admet-854	327	6	the	the	DET
admet-854	327	7	selective	selective	ADJ
admet-854	327	8	binding	binding	NOUN
admet-854	327	9	of	of	ADP
admet-854	327	10	amantadine	amantadine	NOUN
admet-854	327	11	to	to	ADP
admet-854	327	12	the	the	DET
admet-854	327	13	aks	ak	NOUN
admet-854	327	14	’	'	PUNCT
admet-854	327	15	isoforms	isoform	NOUN
admet-854	327	16	implicated	implicate	VERB
admet-854	327	17	in	in	ADP
admet-854	327	18	pd	pd	PROPN
admet-854	327	19	.	.	PUNCT
admet-854	328	1	the	the	DET
admet-854	328	2	δg	δg	PROPN
admet-854	328	3	and	and	CCONJ
admet-854	328	4	ki	ki	PROPN
admet-854	328	5	data	datum	NOUN
admet-854	328	6	provide	provide	VERB
admet-854	328	7	only	only	ADV
admet-854	328	8	a	a	DET
admet-854	328	9	first	first	ADJ
admet-854	328	10	view	view	NOUN
admet-854	328	11	of	of	ADP
admet-854	328	12	the	the	DET
admet-854	328	13	amantadine	amantadine	NOUN
admet-854	328	14	binding	bind	VERB
admet-854	328	15	to	to	ADP
admet-854	328	16	different	different	ADJ
admet-854	328	17	aks	ak	NOUN
admet-854	328	18	.	.	PUNCT
admet-854	329	1	thus	thus	ADV
admet-854	329	2	,	,	PUNCT
admet-854	329	3	a	a	DET
admet-854	329	4	deep	deep	ADJ
admet-854	329	5	analysis	analysis	NOUN
admet-854	329	6	of	of	ADP
admet-854	329	7	the	the	DET
admet-854	329	8	amantadine	amantadine	NOUN
admet-854	329	9	with	with	ADP
admet-854	329	10	the	the	DET
admet-854	329	11	aks	ak	NOUN
admet-854	329	12	residues	residue	NOUN
admet-854	329	13	illustrated	illustrate	VERB
admet-854	329	14	that	that	SCONJ
admet-854	329	15	there	there	PRON
admet-854	329	16	are	be	VERB
admet-854	329	17	notable	notable	ADJ
admet-854	329	18	differences	difference	NOUN
admet-854	329	19	between	between	ADP
admet-854	329	20	all	all	DET
admet-854	329	21	human	human	ADJ
admet-854	329	22	aks	ak	NOUN
admet-854	329	23	investigated	investigate	VERB
admet-854	329	24	.	.	PUNCT
admet-854	330	1	it	it	PRON
admet-854	330	2	was	be	AUX
admet-854	330	3	previously	previously	ADV
admet-854	330	4	described	describe	VERB
admet-854	330	5	a	a	DET
admet-854	330	6	down	down	ADJ
admet-854	330	7	-	-	PUNCT
admet-854	330	8	regulation	regulation	NOUN
admet-854	330	9	of	of	ADP
admet-854	330	10	the	the	DET
admet-854	330	11	mitochondrial	mitochondrial	ADJ
admet-854	330	12	isoforms	isoform	NOUN
admet-854	330	13	ak2	ak2	NOUN
admet-854	330	14	and	and	CCONJ
admet-854	330	15	ak4	ak4	NOUN
admet-854	330	16	in	in	ADP
admet-854	330	17	the	the	DET
admet-854	330	18	stages	stage	NOUN
admet-854	330	19	3	3	NUM
admet-854	330	20	-	-	SYM
admet-854	330	21	6	6	NUM
admet-854	330	22	and	and	CCONJ
admet-854	330	23	an	an	DET
admet-854	330	24	upregulation	upregulation	NOUN
admet-854	330	25	of	of	ADP
admet-854	330	26	the	the	DET
admet-854	330	27	cytosolic	cytosolic	ADJ
admet-854	330	28	isoform	isoform	NOUN
admet-854	330	29	ak1	ak1	ADV
admet-854	330	30	in	in	ADP
admet-854	330	31	the	the	DET
admet-854	330	32	stages	stage	NOUN
admet-854	330	33	5	5	NUM
admet-854	330	34	-	-	SYM
admet-854	330	35	6	6	NUM
admet-854	330	36	,	,	PUNCT
admet-854	330	37	as	as	ADP
admet-854	330	38	compensation	compensation	NOUN
admet-854	330	39	of	of	ADP
admet-854	330	40	altered	altered	ADJ
admet-854	330	41	purine	purine	NOUN
admet-854	330	42	metabolism	metabolism	NOUN
admet-854	330	43	(	(	PUNCT
admet-854	330	44	figure	figure	NOUN
admet-854	330	45	19	19	NUM
admet-854	330	46	)	)	PUNCT
admet-854	331	1	[	[	X
admet-854	331	2	24	24	NUM
admet-854	331	3	]	]	PUNCT
admet-854	331	4	.	.	PUNCT
admet-854	332	1	there	there	PRON
admet-854	332	2	are	be	VERB
admet-854	332	3	well	well	ADV
admet-854	332	4	-	-	PUNCT
admet-854	332	5	known	know	VERB
admet-854	332	6	motor	motor	NOUN
admet-854	332	7	deficits	deficit	NOUN
admet-854	332	8	in	in	ADP
admet-854	332	9	pd	pd	PROPN
admet-854	332	10	–	–	PUNCT
admet-854	332	11	slowness	slowness	NOUN
admet-854	332	12	of	of	ADP
admet-854	332	13	movement	movement	NOUN
admet-854	332	14	,	,	PUNCT
admet-854	332	15	muscle	muscle	NOUN
admet-854	332	16	rigidity	rigidity	NOUN
admet-854	332	17	,	,	PUNCT
admet-854	332	18	and	and	CCONJ
admet-854	332	19	tremor	tremor	NOUN
admet-854	332	20	at	at	ADP
admet-854	332	21	rest	rest	NOUN
admet-854	332	22	,	,	PUNCT
admet-854	332	23	the	the	DET
admet-854	332	24	tremor	tremor	NOUN
admet-854	332	25	that	that	PRON
admet-854	332	26	decreases	decrease	VERB
admet-854	332	27	when	when	SCONJ
admet-854	332	28	the	the	DET
admet-854	332	29	body	body	NOUN
admet-854	332	30	is	be	AUX
admet-854	332	31	actively	actively	ADV
admet-854	332	32	engaged	engage	VERB
admet-854	332	33	in	in	ADP
admet-854	332	34	purposeful	purposeful	ADJ
admet-854	332	35	activity	activity	NOUN
admet-854	332	36	[	[	X
admet-854	332	37	61	61	NUM
admet-854	332	38	]	]	PUNCT
admet-854	332	39	–	–	PUNCT
admet-854	332	40	[	[	X
admet-854	332	41	63	63	NUM
admet-854	332	42	]	]	PUNCT
admet-854	332	43	.	.	PUNCT
admet-854	333	1	the	the	DET
admet-854	333	2	cytosolic	cytosolic	PROPN
admet-854	333	3	ak1	ak1	NOUN
admet-854	333	4	and	and	CCONJ
admet-854	333	5	the	the	DET
admet-854	333	6	mitochondrial	mitochondrial	ADJ
admet-854	333	7	ak2	ak2	NOUN
admet-854	333	8	are	be	AUX
admet-854	333	9	dysregulated	dysregulate	VERB
admet-854	333	10	in	in	ADP
admet-854	333	11	different	different	ADJ
admet-854	333	12	muscle	muscle	NOUN
admet-854	333	13	pathology	pathology	NOUN
admet-854	333	14	.	.	PUNCT
admet-854	334	1	in	in	ADP
admet-854	334	2	contrast	contrast	NOUN
admet-854	334	3	with	with	ADP
admet-854	334	4	pd	pd	PROPN
admet-854	334	5	,	,	PUNCT
admet-854	334	6	in	in	ADP
admet-854	334	7	duchenne	duchenne	NOUN
admet-854	334	8	muscular	muscular	ADJ
admet-854	334	9	dystrophy	dystrophy	NOUN
admet-854	334	10	–	–	PUNCT
admet-854	334	11	an	an	DET
admet-854	334	12	x	x	ADV
admet-854	334	13	-	-	ADJ
admet-854	334	14	linked	link	VERB
admet-854	334	15	recessive	recessive	ADJ
admet-854	334	16	disease	disease	NOUN
admet-854	334	17	–	–	PUNCT
admet-854	334	18	there	there	PRON
admet-854	334	19	is	be	VERB
admet-854	334	20	a	a	DET
admet-854	334	21	progressive	progressive	ADJ
admet-854	334	22	weakness	weakness	NOUN
admet-854	334	23	mainly	mainly	ADV
admet-854	334	24	of	of	ADP
admet-854	334	25	the	the	DET
admet-854	334	26	pelvic	pelvic	ADJ
admet-854	334	27	girdle	girdle	NOUN
admet-854	334	28	and	and	CCONJ
admet-854	334	29	shoulder	shoulder	NOUN
admet-854	334	30	girdle	girdle	NOUN
admet-854	334	31	,	,	PUNCT
admet-854	334	32	pseudohypertrophy	pseudohypertrophy	NOUN
admet-854	334	33	due	due	ADP
admet-854	334	34	to	to	ADP
admet-854	334	35	the	the	DET
admet-854	334	36	infiltration	infiltration	NOUN
admet-854	334	37	by	by	ADP
admet-854	334	38	fat	fat	ADJ
admet-854	334	39	and	and	CCONJ
admet-854	334	40	connective	connective	ADJ
admet-854	334	41	tissue	tissue	NOUN
admet-854	334	42	with	with	ADP
admet-854	334	43	immobilization	immobilization	NOUN
admet-854	334	44	at	at	ADP
admet-854	334	45	young	young	ADJ
admet-854	334	46	ages	age	NOUN
admet-854	334	47	and	and	CCONJ
admet-854	334	48	cardiomyopathy	cardiomyopathy	ADJ
admet-854	334	49	[	[	X
admet-854	334	50	64	64	NUM
admet-854	334	51	]	]	PUNCT
admet-854	334	52	,	,	PUNCT
admet-854	334	53	[	[	X
admet-854	334	54	65	65	NUM
admet-854	334	55	]	]	PUNCT
admet-854	334	56	.	.	PUNCT
admet-854	335	1	the	the	DET
admet-854	335	2	role	role	NOUN
admet-854	335	3	of	of	ADP
admet-854	335	4	ak1	ak1	NOUN
admet-854	335	5	in	in	ADP
admet-854	335	6	inflammation	inflammation	NOUN
admet-854	335	7	has	have	AUX
admet-854	335	8	been	be	AUX
admet-854	335	9	demonstrated	demonstrate	VERB
admet-854	335	10	,	,	PUNCT
admet-854	335	11	but	but	CCONJ
admet-854	335	12	its	its	PRON
admet-854	335	13	role	role	NOUN
admet-854	335	14	in	in	ADP
admet-854	335	15	maintaining	maintain	VERB
admet-854	335	16	neuroinflammation	neuroinflammation	NOUN
admet-854	335	17	is	be	AUX
admet-854	335	18	not	not	PART
admet-854	335	19	yet	yet	ADV
admet-854	335	20	known	know	VERB
admet-854	335	21	(	(	PUNCT
admet-854	335	22	figure	figure	NOUN
admet-854	335	23	19	19	NUM
admet-854	335	24	)	)	PUNCT
admet-854	336	1	[	[	X
admet-854	336	2	66	66	NUM
admet-854	336	3	]	]	PUNCT
admet-854	336	4	.	.	PUNCT
admet-854	337	1	figure	figure	NOUN
admet-854	337	2	19	19	NUM
admet-854	337	3	.	.	PUNCT
admet-854	338	1	the	the	DET
admet-854	338	2	involvement	involvement	NOUN
admet-854	338	3	of	of	ADP
admet-854	338	4	human	human	PROPN
admet-854	338	5	ak1	ak1	PROPN
admet-854	338	6	and	and	CCONJ
admet-854	338	7	human	human	ADJ
admet-854	338	8	ak2	ak2	NOUN
admet-854	338	9	in	in	ADP
admet-854	338	10	pd	pd	PROPN
admet-854	338	11	,	,	PUNCT
admet-854	338	12	inflammation	inflammation	NOUN
admet-854	338	13	,	,	PUNCT
admet-854	338	14	and	and	CCONJ
admet-854	338	15	muscle	muscle	NOUN
admet-854	338	16	activity	activity	NOUN
admet-854	338	17	.	.	PUNCT
admet-854	339	1	the	the	DET
admet-854	339	2	amantadine	amantadine	NOUN
admet-854	339	3	treatment	treatment	NOUN
admet-854	339	4	efficacy	efficacy	NOUN
admet-854	339	5	in	in	ADP
admet-854	339	6	pd	pd	PROPN
admet-854	339	7	developed	develop	VERB
admet-854	339	8	the	the	DET
admet-854	339	9	hypothesis	hypothesis	NOUN
admet-854	339	10	that	that	PRON
admet-854	339	11	amantadine	amantadine	NOUN
admet-854	339	12	–	–	PUNCT
admet-854	339	13	ak	ak	NOUN
admet-854	339	14	interactions	interaction	NOUN
admet-854	339	15	.	.	PUNCT
admet-854	340	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	340	2	mihaela	mihaela	PROPN
admet-854	340	3	ileana	ileana	PROPN
admet-854	340	4	ionescu	ionescu	PROPN
admet-854	340	5	admet	admet	PROPN
admet-854	340	6	&	&	CCONJ
admet-854	340	7	dmpk	dmpk	PROPN
admet-854	340	8	8(2	8(2	NUM
admet-854	340	9	)	)	PUNCT
admet-854	340	10	(	(	PUNCT
admet-854	340	11	2020	2020	NUM
admet-854	340	12	)	)	PUNCT
admet-854	340	13	149	149	NUM
admet-854	340	14	-	-	SYM
admet-854	340	15	175	175	NUM
admet-854	340	16	168	168	NUM
admet-854	340	17	according	accord	VERB
admet-854	340	18	to	to	ADP
admet-854	340	19	the	the	DET
admet-854	340	20	scientific	scientific	ADJ
admet-854	340	21	literature	literature	NOUN
admet-854	340	22	,	,	PUNCT
admet-854	340	23	there	there	PRON
admet-854	340	24	is	be	VERB
admet-854	340	25	no	no	DET
admet-854	340	26	connection	connection	NOUN
admet-854	340	27	between	between	ADP
admet-854	340	28	the	the	DET
admet-854	340	29	amantadine	amantadine	NOUN
admet-854	340	30	and	and	CCONJ
admet-854	340	31	aks	ak	NOUN
admet-854	340	32	in	in	ADP
admet-854	340	33	pd	pd	PROPN
admet-854	340	34	.	.	PUNCT
admet-854	341	1	however	however	ADV
admet-854	341	2	,	,	PUNCT
admet-854	341	3	because	because	SCONJ
admet-854	341	4	the	the	DET
admet-854	341	5	mechanism	mechanism	NOUN
admet-854	341	6	of	of	ADP
admet-854	341	7	amantadine	amantadine	NOUN
admet-854	341	8	in	in	ADP
admet-854	341	9	pd	pd	PROPN
admet-854	341	10	is	be	AUX
admet-854	341	11	not	not	PART
admet-854	341	12	yet	yet	ADV
admet-854	341	13	known	know	VERB
admet-854	341	14	,	,	PUNCT
admet-854	341	15	the	the	DET
admet-854	341	16	investigation	investigation	NOUN
admet-854	341	17	of	of	ADP
admet-854	341	18	the	the	DET
admet-854	341	19	possible	possible	ADJ
admet-854	341	20	mechanism	mechanism	NOUN
admet-854	341	21	of	of	ADP
admet-854	341	22	amantadine	amantadine	NOUN
admet-854	341	23	is	be	AUX
admet-854	341	24	of	of	ADP
admet-854	341	25	great	great	ADJ
admet-854	341	26	interest	interest	NOUN
admet-854	341	27	.	.	PUNCT
admet-854	342	1	the	the	DET
admet-854	342	2	present	present	ADJ
admet-854	342	3	study	study	NOUN
admet-854	342	4	was	be	AUX
admet-854	342	5	conducted	conduct	VERB
admet-854	342	6	with	with	ADP
admet-854	342	7	the	the	DET
admet-854	342	8	premise	premise	NOUN
admet-854	342	9	that	that	SCONJ
admet-854	342	10	some	some	DET
admet-854	342	11	markers	marker	NOUN
admet-854	342	12	up	up	ADV
admet-854	342	13	-	-	PUNCT
admet-854	342	14	regulated	regulated	ADJ
admet-854	342	15	or	or	CCONJ
admet-854	342	16	down	down	ADV
admet-854	342	17	-	-	PUNCT
admet-854	342	18	regulated	regulate	VERB
admet-854	342	19	in	in	ADP
admet-854	342	20	pd	pd	PROPN
admet-854	342	21	could	could	AUX
admet-854	342	22	be	be	AUX
admet-854	342	23	the	the	DET
admet-854	342	24	target	target	NOUN
admet-854	342	25	for	for	ADP
admet-854	342	26	amantadine	amantadine	NOUN
admet-854	342	27	.	.	PUNCT
admet-854	343	1	many	many	ADJ
admet-854	343	2	studies	study	NOUN
admet-854	343	3	described	describe	VERB
admet-854	343	4	the	the	DET
admet-854	343	5	association	association	NOUN
admet-854	343	6	of	of	ADP
admet-854	343	7	some	some	DET
admet-854	343	8	clinical	clinical	ADJ
admet-854	343	9	symptoms	symptom	NOUN
admet-854	343	10	with	with	ADP
admet-854	343	11	dysregulation	dysregulation	NOUN
admet-854	343	12	of	of	ADP
admet-854	343	13	different	different	ADJ
admet-854	343	14	enzymes	enzyme	NOUN
admet-854	343	15	.	.	PUNCT
admet-854	344	1	the	the	DET
admet-854	344	2	observation	observation	NOUN
admet-854	344	3	that	that	SCONJ
admet-854	344	4	many	many	ADJ
admet-854	344	5	aks	ak	NOUN
admet-854	344	6	isoforms	isoform	NOUN
admet-854	344	7	are	be	AUX
admet-854	344	8	altered	alter	VERB
admet-854	344	9	in	in	ADP
admet-854	344	10	pd	pd	PROPN
admet-854	344	11	leads	lead	VERB
admet-854	344	12	to	to	ADP
admet-854	344	13	the	the	DET
admet-854	344	14	hypothesis	hypothesis	NOUN
admet-854	344	15	that	that	SCONJ
admet-854	344	16	there	there	PRON
admet-854	344	17	is	be	VERB
admet-854	344	18	a	a	DET
admet-854	344	19	connection	connection	NOUN
admet-854	344	20	between	between	ADP
admet-854	344	21	amantadine	amantadine	NOUN
admet-854	344	22	and	and	CCONJ
admet-854	344	23	these	these	DET
admet-854	344	24	aks	ak	NOUN
admet-854	344	25	isoforms	isoform	NOUN
admet-854	344	26	.	.	PUNCT
admet-854	345	1	also	also	ADV
admet-854	345	2	,	,	PUNCT
admet-854	345	3	other	other	ADJ
admet-854	345	4	enzymes	enzyme	NOUN
admet-854	345	5	already	already	ADV
admet-854	345	6	described	describe	VERB
admet-854	345	7	to	to	PART
admet-854	345	8	be	be	AUX
admet-854	345	9	dysregulated	dysregulate	VERB
admet-854	345	10	in	in	ADP
admet-854	345	11	pd	pd	PROPN
admet-854	345	12	was	be	AUX
admet-854	345	13	investigated	investigate	VERB
admet-854	345	14	–	–	PUNCT
admet-854	345	15	aprt	aprt	NOUN
admet-854	345	16	,	,	PUNCT
admet-854	345	17	nt5e	nt5e	PROPN
admet-854	345	18	,	,	PUNCT
admet-854	345	19	entpd1	entpd1	NOUN
admet-854	345	20	,	,	PUNCT
admet-854	345	21	ndk3	ndk3	PROPN
admet-854	345	22	,	,	PUNCT
admet-854	345	23	and	and	CCONJ
admet-854	345	24	pnp1	pnp1	PROPN
admet-854	346	1	[	[	X
admet-854	346	2	24	24	NUM
admet-854	346	3	]	]	PUNCT
admet-854	346	4	.	.	PUNCT
admet-854	347	1	more	more	ADJ
admet-854	347	2	,	,	PUNCT
admet-854	347	3	ck	ck	PROPN
admet-854	347	4	was	be	AUX
admet-854	347	5	included	include	VERB
admet-854	347	6	in	in	ADP
admet-854	347	7	the	the	DET
admet-854	347	8	study	study	NOUN
admet-854	347	9	because	because	SCONJ
admet-854	347	10	of	of	ADP
admet-854	347	11	its	its	PRON
admet-854	347	12	proven	prove	VERB
admet-854	347	13	involvement	involvement	NOUN
admet-854	347	14	in	in	ADP
admet-854	347	15	some	some	DET
admet-854	347	16	muscle	muscle	NOUN
admet-854	347	17	diseases	disease	NOUN
admet-854	347	18	[	[	X
admet-854	347	19	27	27	NUM
admet-854	347	20	]	]	PUNCT
admet-854	347	21	.	.	PUNCT
admet-854	348	1	our	our	PRON
admet-854	348	2	experiments	experiment	NOUN
admet-854	348	3	show	show	VERB
admet-854	348	4	that	that	SCONJ
admet-854	348	5	the	the	DET
admet-854	348	6	human	human	ADJ
admet-854	348	7	cytosolic	cytosolic	PROPN
admet-854	348	8	ak1	ak1	PROPN
admet-854	348	9	interacts	interact	VERB
admet-854	348	10	mainly	mainly	ADV
admet-854	348	11	with	with	ADP
admet-854	348	12	ionized	ionized	ADJ
admet-854	348	13	amantadine	amantadine	NOUN
admet-854	348	14	by	by	ADP
admet-854	348	15	residues	residue	NOUN
admet-854	348	16	from	from	ADP
admet-854	348	17	the	the	DET
admet-854	348	18	amp	amp	NOUN
admet-854	348	19	binding	bind	VERB
admet-854	348	20	region	region	NOUN
admet-854	348	21	.	.	PUNCT
admet-854	349	1	even	even	ADV
admet-854	349	2	if	if	SCONJ
admet-854	349	3	the	the	DET
admet-854	349	4	two	two	NUM
admet-854	349	5	human	human	ADJ
admet-854	349	6	ak1s	ak1s	PROPN
admet-854	349	7	analyzed	analyze	VERB
admet-854	349	8	do	do	AUX
admet-854	349	9	not	not	PART
admet-854	349	10	form	form	VERB
admet-854	349	11	the	the	DET
admet-854	349	12	same	same	ADJ
admet-854	349	13	interactions	interaction	NOUN
admet-854	349	14	with	with	ADP
admet-854	349	15	amantadine	amantadine	NOUN
admet-854	349	16	,	,	PUNCT
admet-854	349	17	the	the	DET
admet-854	349	18	observation	observation	NOUN
admet-854	349	19	could	could	AUX
admet-854	349	20	be	be	AUX
admet-854	349	21	aware	aware	ADJ
admet-854	349	22	of	of	ADP
admet-854	349	23	the	the	DET
admet-854	349	24	efficacy	efficacy	NOUN
admet-854	349	25	of	of	ADP
admet-854	349	26	the	the	DET
admet-854	349	27	amantadine	amantadine	NOUN
admet-854	349	28	in	in	ADP
admet-854	349	29	the	the	DET
admet-854	349	30	late	late	ADJ
admet-854	349	31	stages	stage	NOUN
admet-854	349	32	of	of	ADP
admet-854	349	33	pd	pd	PROPN
admet-854	349	34	,	,	PUNCT
admet-854	349	35	because	because	SCONJ
admet-854	349	36	,	,	PUNCT
admet-854	349	37	as	as	SCONJ
admet-854	349	38	mentioned	mention	VERB
admet-854	349	39	earlier	early	ADV
admet-854	349	40	,	,	PUNCT
admet-854	349	41	ak1	ak1	ADJ
admet-854	349	42	activity	activity	NOUN
admet-854	349	43	could	could	AUX
admet-854	349	44	compensate	compensate	VERB
admet-854	349	45	for	for	ADP
admet-854	349	46	purine	purine	NOUN
admet-854	349	47	metabolism	metabolism	NOUN
admet-854	349	48	dysfunctions	dysfunction	NOUN
admet-854	349	49	.	.	PUNCT
admet-854	350	1	regarding	regard	VERB
admet-854	350	2	ak1	ak1	NOUN
admet-854	350	3	from	from	ADP
admet-854	350	4	other	other	ADJ
admet-854	350	5	species	specie	NOUN
admet-854	350	6	,	,	PUNCT
admet-854	350	7	the	the	DET
admet-854	350	8	zebrafish	zebrafish	ADJ
admet-854	350	9	ak1	ak1	NOUN
admet-854	350	10	interactions	interaction	NOUN
admet-854	350	11	with	with	ADP
admet-854	350	12	amantadine	amantadine	NOUN
admet-854	350	13	are	be	AUX
admet-854	350	14	more	more	ADV
admet-854	350	15	similar	similar	ADJ
admet-854	350	16	to	to	ADP
admet-854	350	17	those	those	PRON
admet-854	350	18	of	of	ADP
admet-854	350	19	the	the	DET
admet-854	350	20	ak	ak	PROPN
admet-854	350	21	from	from	ADP
admet-854	350	22	b.stearothermophilus	b.stearothermophilus	NOUN
admet-854	350	23	.	.	PUNCT
admet-854	351	1	moreover	moreover	ADV
admet-854	351	2	,	,	PUNCT
admet-854	351	3	the	the	DET
admet-854	351	4	interactions	interaction	NOUN
admet-854	351	5	with	with	ADP
admet-854	351	6	ionized	ionized	ADJ
admet-854	351	7	amantadine	amantadine	NOUN
admet-854	351	8	are	be	AUX
admet-854	351	9	different	different	ADJ
admet-854	351	10	for	for	ADP
admet-854	351	11	the	the	DET
admet-854	351	12	three	three	NUM
admet-854	351	13	ak1	ak1	ADJ
admet-854	351	14	enzymes	enzyme	NOUN
admet-854	351	15	analyzed	analyze	VERB
admet-854	351	16	.	.	PUNCT
admet-854	352	1	regarding	regard	VERB
admet-854	352	2	the	the	DET
admet-854	352	3	mitochondrial	mitochondrial	ADJ
admet-854	352	4	human	human	ADJ
admet-854	352	5	ak2	ak2	NOUN
admet-854	352	6	,	,	PUNCT
admet-854	352	7	the	the	DET
admet-854	352	8	interactions	interaction	NOUN
admet-854	352	9	with	with	ADP
admet-854	352	10	ionized	ionized	ADJ
admet-854	352	11	amantadine	amantadine	NOUN
admet-854	352	12	are	be	AUX
admet-854	352	13	most	most	ADV
admet-854	352	14	similar	similar	ADJ
admet-854	352	15	to	to	ADP
admet-854	352	16	ak1	ak1	PROPN
admet-854	352	17	(	(	PUNCT
admet-854	352	18	pdb	pdb	PROPN
admet-854	352	19	i	i	PROPN
admet-854	352	20	d	d	PROPN
admet-854	352	21	1z83	1z83	X
admet-854	352	22	)	)	PUNCT
admet-854	352	23	with	with	ADP
admet-854	352	24	five	five	NUM
admet-854	352	25	residues	residue	NOUN
admet-854	352	26	in	in	ADP
admet-854	352	27	common	common	ADJ
admet-854	352	28	–	–	PUNCT
admet-854	352	29	thr44	thr44	PROPN
admet-854	352	30	,	,	PUNCT
admet-854	352	31	val74	val74	NOUN
admet-854	352	32	,	,	PUNCT
admet-854	352	33	phe101	phe101	PROPN
admet-854	352	34	,	,	PUNCT
admet-854	352	35	arg103	arg103	PROPN
admet-854	352	36	,	,	PUNCT
admet-854	352	37	and	and	CCONJ
admet-854	352	38	gln107	gln107	PROPN
admet-854	352	39	.	.	PUNCT
admet-854	353	1	thus	thus	ADV
admet-854	353	2	,	,	PUNCT
admet-854	353	3	the	the	DET
admet-854	353	4	results	result	NOUN
admet-854	353	5	of	of	ADP
admet-854	353	6	the	the	DET
admet-854	353	7	present	present	ADJ
admet-854	353	8	study	study	NOUN
admet-854	353	9	highlight	highlight	VERB
admet-854	353	10	the	the	DET
admet-854	353	11	relevance	relevance	NOUN
admet-854	353	12	of	of	ADP
admet-854	353	13	ak1	ak1	NOUN
admet-854	353	14	and	and	CCONJ
admet-854	353	15	ak2	ak2	NOUN
admet-854	353	16	in	in	ADP
admet-854	353	17	pd	pd	PROPN
admet-854	353	18	and	and	CCONJ
admet-854	353	19	provide	provide	VERB
admet-854	353	20	a	a	DET
admet-854	353	21	valid	valid	ADJ
admet-854	353	22	perspective	perspective	NOUN
admet-854	353	23	for	for	ADP
admet-854	353	24	further	further	ADJ
admet-854	353	25	investigation	investigation	NOUN
admet-854	353	26	of	of	ADP
admet-854	353	27	the	the	DET
admet-854	353	28	role	role	NOUN
admet-854	353	29	of	of	ADP
admet-854	353	30	amantadine	amantadine	NOUN
admet-854	353	31	in	in	ADP
admet-854	353	32	inhibiting	inhibit	VERB
admet-854	353	33	these	these	DET
admet-854	353	34	enzymes	enzyme	NOUN
admet-854	353	35	.	.	PUNCT
admet-854	354	1	the	the	DET
admet-854	354	2	connection	connection	NOUN
admet-854	354	3	between	between	ADP
admet-854	354	4	cytosolic	cytosolic	NOUN
admet-854	354	5	and	and	CCONJ
admet-854	354	6	mitochondrial	mitochondrial	ADJ
admet-854	354	7	human	human	ADJ
admet-854	354	8	aks	ak	NOUN
admet-854	354	9	was	be	AUX
admet-854	354	10	extensively	extensively	ADV
admet-854	354	11	studied	study	VERB
admet-854	354	12	by	by	ADP
admet-854	354	13	dzeja	dzeja	PROPN
admet-854	354	14	et	et	PROPN
admet-854	354	15	al	al	PROPN
admet-854	354	16	.	.	PROPN
admet-854	354	17	who	who	PRON
admet-854	354	18	made	make	VERB
admet-854	354	19	a	a	DET
admet-854	354	20	very	very	ADV
admet-854	354	21	clear	clear	ADJ
admet-854	354	22	demonstration	demonstration	NOUN
admet-854	354	23	of	of	ADP
admet-854	354	24	the	the	DET
admet-854	354	25	type	type	NOUN
admet-854	354	26	”	"	PUNCT
admet-854	354	27	bucket	bucket	NOUN
admet-854	354	28	-	-	PUNCT
admet-854	354	29	brigade	brigade	NOUN
admet-854	354	30	”	"	PUNCT
admet-854	354	31	process	process	NOUN
admet-854	354	32	by	by	ADP
admet-854	354	33	which	which	PRON
admet-854	354	34	ak1	ak1	NOUN
admet-854	354	35	and	and	CCONJ
admet-854	354	36	ak2	ak2	NOUN
admet-854	354	37	isoforms	isoform	NOUN
admet-854	354	38	facilitate	facilitate	VERB
admet-854	354	39	the	the	DET
admet-854	354	40	transfer	transfer	NOUN
admet-854	354	41	of	of	ADP
admet-854	354	42	the	the	DET
admet-854	354	43	enzyme	enzyme	NOUN
admet-854	354	44	substrates	substrate	NOUN
admet-854	354	45	without	without	ADP
admet-854	354	46	changes	change	NOUN
admet-854	354	47	in	in	ADP
admet-854	354	48	the	the	DET
admet-854	354	49	metabolite	metabolite	NOUN
admet-854	354	50	concentration	concentration	NOUN
admet-854	354	51	in	in	ADP
admet-854	354	52	the	the	DET
admet-854	354	53	cellular	cellular	ADJ
admet-854	354	54	compartments	compartment	NOUN
admet-854	355	1	[	[	X
admet-854	355	2	67	67	NUM
admet-854	355	3	]	]	PUNCT
admet-854	355	4	.	.	PUNCT
admet-854	356	1	it	it	PRON
admet-854	356	2	is	be	AUX
admet-854	356	3	not	not	PART
admet-854	356	4	possible	possible	ADJ
admet-854	356	5	to	to	PART
admet-854	356	6	establish	establish	VERB
admet-854	356	7	the	the	DET
admet-854	356	8	mechanism	mechanism	NOUN
admet-854	356	9	of	of	ADP
admet-854	356	10	action	action	NOUN
admet-854	356	11	of	of	ADP
admet-854	356	12	amantadine	amantadine	NOUN
admet-854	356	13	in	in	ADP
admet-854	356	14	pd	pd	NOUN
admet-854	356	15	observing	observe	VERB
admet-854	356	16	only	only	ADV
admet-854	356	17	the	the	DET
admet-854	356	18	interaction	interaction	NOUN
admet-854	356	19	of	of	ADP
admet-854	356	20	the	the	DET
admet-854	356	21	drug	drug	NOUN
admet-854	356	22	with	with	ADP
admet-854	356	23	aks	ak	NOUN
admet-854	356	24	,	,	PUNCT
admet-854	356	25	but	but	CCONJ
admet-854	356	26	the	the	DET
admet-854	356	27	results	result	NOUN
admet-854	356	28	of	of	ADP
admet-854	356	29	the	the	DET
admet-854	356	30	present	present	ADJ
admet-854	356	31	study	study	NOUN
admet-854	356	32	provide	provide	VERB
admet-854	356	33	a	a	DET
admet-854	356	34	valuable	valuable	ADJ
admet-854	356	35	perspective	perspective	NOUN
admet-854	356	36	for	for	ADP
admet-854	356	37	understanding	understand	VERB
admet-854	356	38	the	the	DET
admet-854	356	39	pathogenesis	pathogenesis	NOUN
admet-854	356	40	of	of	ADP
admet-854	356	41	pd	pd	PROPN
admet-854	356	42	.	.	PUNCT
admet-854	357	1	so	so	ADV
admet-854	357	2	the	the	DET
admet-854	357	3	next	next	ADJ
admet-854	357	4	step	step	NOUN
admet-854	357	5	was	be	AUX
admet-854	357	6	to	to	PART
admet-854	357	7	analyze	analyze	VERB
admet-854	357	8	of	of	ADP
admet-854	357	9	a	a	DET
admet-854	357	10	large	large	ADJ
admet-854	357	11	group	group	NOUN
admet-854	357	12	of	of	ADP
admet-854	357	13	proteins	protein	NOUN
admet-854	357	14	.	.	PUNCT
admet-854	358	1	among	among	ADP
admet-854	358	2	the	the	DET
admet-854	358	3	enzymes	enzyme	NOUN
admet-854	358	4	analyzed	analyze	VERB
admet-854	358	5	for	for	ADP
admet-854	358	6	their	their	PRON
admet-854	358	7	affinity	affinity	NOUN
admet-854	358	8	for	for	ADP
admet-854	358	9	amantadine	amantadine	NOUN
admet-854	358	10	,	,	PUNCT
admet-854	358	11	aprt	aprt	PROPN
admet-854	358	12	shows	show	VERB
admet-854	358	13	remarkable	remarkable	ADJ
admet-854	358	14	results	result	NOUN
admet-854	358	15	.	.	PUNCT
admet-854	359	1	because	because	SCONJ
admet-854	359	2	there	there	PRON
admet-854	359	3	are	be	VERB
admet-854	359	4	available	available	ADJ
admet-854	359	5	many	many	ADJ
admet-854	359	6	aprts	aprt	NOUN
admet-854	359	7	x	x	NOUN
admet-854	359	8	-	-	NOUN
admet-854	359	9	ray	ray	ADJ
admet-854	359	10	3d	3d	PROPN
admet-854	359	11	structures	structure	NOUN
admet-854	359	12	co	co	VERB
admet-854	359	13	-	-	VERB
admet-854	359	14	crystallized	crystallize	VERB
admet-854	359	15	with	with	ADP
admet-854	359	16	amp	amp	NOUN
admet-854	359	17	and	and	CCONJ
admet-854	359	18	with	with	ADP
admet-854	359	19	adenine	adenine	NOUN
admet-854	359	20	,	,	PUNCT
admet-854	359	21	we	we	PRON
admet-854	359	22	were	be	AUX
admet-854	359	23	able	able	ADJ
admet-854	359	24	to	to	PART
admet-854	359	25	compare	compare	VERB
admet-854	359	26	the	the	DET
admet-854	359	27	molecular	molecular	ADJ
admet-854	359	28	docking	docking	NOUN
admet-854	359	29	results	result	NOUN
admet-854	359	30	.	.	PUNCT
admet-854	360	1	the	the	DET
admet-854	360	2	molecular	molecular	ADJ
admet-854	360	3	docking	docking	NOUN
admet-854	360	4	of	of	ADP
admet-854	360	5	amantadine	amantadine	NOUN
admet-854	360	6	ionized	ionize	VERB
admet-854	360	7	form	form	NOUN
admet-854	360	8	with	with	ADP
admet-854	360	9	aprts	aprt	NOUN
admet-854	360	10	demonstrated	demonstrate	VERB
admet-854	360	11	that	that	SCONJ
admet-854	360	12	amantadine	amantadine	NOUN
admet-854	360	13	interacts	interact	VERB
admet-854	360	14	with	with	ADP
admet-854	360	15	amp	amp	NOUN
admet-854	360	16	-	-	PUNCT
admet-854	360	17	binding	bind	VERB
admet-854	360	18	residues	residue	NOUN
admet-854	360	19	.	.	PUNCT
admet-854	361	1	although	although	SCONJ
admet-854	361	2	the	the	DET
admet-854	361	3	structures	structure	NOUN
admet-854	361	4	of	of	ADP
admet-854	361	5	aprts	aprt	NOUN
admet-854	361	6	co	co	VERB
admet-854	361	7	-	-	VERB
admet-854	361	8	crystallized	crystallize	VERB
admet-854	361	9	with	with	ADP
admet-854	361	10	adenine	adenine	NOUN
admet-854	361	11	shows	show	VERB
admet-854	361	12	identical	identical	ADJ
admet-854	361	13	residues	residue	NOUN
admet-854	361	14	that	that	PRON
admet-854	361	15	bind	bind	VERB
admet-854	361	16	amantadine	amantadine	NOUN
admet-854	361	17	and	and	CCONJ
admet-854	361	18	adenine	adenine	NOUN
admet-854	361	19	,	,	PUNCT
admet-854	361	20	there	there	PRON
admet-854	361	21	are	be	VERB
admet-854	361	22	some	some	DET
admet-854	361	23	differences	difference	NOUN
admet-854	361	24	between	between	ADP
admet-854	361	25	the	the	DET
admet-854	361	26	aprts	aprt	NOUN
admet-854	361	27	structures	structure	NOUN
admet-854	361	28	tested	test	VERB
admet-854	361	29	.	.	PUNCT
admet-854	362	1	contrary	contrary	PROPN
admet-854	362	2	,	,	PUNCT
admet-854	362	3	the	the	DET
admet-854	362	4	results	result	NOUN
admet-854	362	5	obtained	obtain	VERB
admet-854	362	6	by	by	ADP
admet-854	362	7	molecular	molecular	ADJ
admet-854	362	8	docking	docking	NOUN
admet-854	362	9	of	of	ADP
admet-854	362	10	amantadine	amantadine	NOUN
admet-854	362	11	with	with	ADP
admet-854	362	12	aprts	aprt	NOUN
admet-854	362	13	x	x	NOUN
admet-854	362	14	-	-	NOUN
admet-854	362	15	ray	ray	ADJ
admet-854	362	16	3d	3d	PROPN
admet-854	362	17	structures	structure	NOUN
admet-854	362	18	co	co	VERB
admet-854	362	19	-	-	VERB
admet-854	362	20	crystallized	crystallize	VERB
admet-854	362	21	with	with	ADP
admet-854	362	22	amp	amp	NOUN
admet-854	362	23	strongly	strongly	ADV
admet-854	362	24	indicated	indicate	VERB
admet-854	362	25	that	that	SCONJ
admet-854	362	26	amantadine	amantadine	NOUN
admet-854	362	27	could	could	AUX
admet-854	362	28	target	target	VERB
admet-854	362	29	adenine	adenine	ADJ
admet-854	362	30	metabolism	metabolism	NOUN
admet-854	362	31	.	.	PUNCT
admet-854	363	1	here	here	ADV
admet-854	363	2	,	,	PUNCT
admet-854	363	3	a	a	DET
admet-854	363	4	preliminary	preliminary	ADJ
admet-854	363	5	analysis	analysis	NOUN
admet-854	363	6	of	of	ADP
admet-854	363	7	some	some	DET
admet-854	363	8	key	key	ADJ
admet-854	363	9	factors	factor	NOUN
admet-854	363	10	described	describe	VERB
admet-854	363	11	in	in	ADP
admet-854	363	12	pd	pd	PROPN
admet-854	363	13	pathogenesis	pathogenesis	NOUN
admet-854	363	14	reveals	reveal	VERB
admet-854	363	15	that	that	SCONJ
admet-854	363	16	there	there	PRON
admet-854	363	17	are	be	VERB
admet-854	363	18	at	at	ADV
admet-854	363	19	least	least	ADV
admet-854	363	20	two	two	NUM
admet-854	363	21	enzymes	enzyme	NOUN
admet-854	363	22	involved	involve	VERB
admet-854	363	23	in	in	ADP
admet-854	363	24	adenine	adenine	ADJ
admet-854	363	25	metabolism	metabolism	NOUN
admet-854	363	26	that	that	PRON
admet-854	363	27	worth	worth	ADJ
admet-854	363	28	further	further	ADJ
admet-854	363	29	investigation	investigation	NOUN
admet-854	363	30	–	–	PUNCT
admet-854	363	31	ak	ak	PROPN
admet-854	363	32	and	and	CCONJ
admet-854	363	33	aprt	aprt	PROPN
admet-854	363	34	.	.	PUNCT
admet-854	364	1	then	then	ADV
admet-854	364	2	,	,	PUNCT
admet-854	364	3	before	before	ADP
admet-854	364	4	an	an	DET
admet-854	364	5	experimental	experimental	ADJ
admet-854	364	6	confirmation	confirmation	NOUN
admet-854	364	7	of	of	ADP
admet-854	364	8	the	the	DET
admet-854	364	9	molecular	molecular	ADJ
admet-854	364	10	docking	docking	NOUN
admet-854	364	11	results	result	NOUN
admet-854	364	12	,	,	PUNCT
admet-854	364	13	a	a	DET
admet-854	364	14	molecular	molecular	ADJ
admet-854	364	15	dynamics	dynamic	NOUN
admet-854	364	16	simulation	simulation	NOUN
admet-854	364	17	study	study	NOUN
admet-854	364	18	aid	aid	NOUN
admet-854	364	19	to	to	PART
admet-854	364	20	observe	observe	VERB
admet-854	364	21	the	the	DET
admet-854	364	22	proper	proper	ADJ
admet-854	364	23	binding	binding	NOUN
admet-854	364	24	of	of	ADP
admet-854	364	25	amantadine	amantadine	NOUN
admet-854	364	26	.	.	PUNCT
admet-854	365	1	the	the	DET
admet-854	365	2	present	present	ADJ
admet-854	365	3	study	study	NOUN
admet-854	365	4	aimed	aim	VERB
admet-854	365	5	to	to	PART
admet-854	365	6	try	try	VERB
admet-854	365	7	to	to	PART
admet-854	365	8	make	make	VERB
admet-854	365	9	sense	sense	NOUN
admet-854	365	10	of	of	ADP
admet-854	365	11	the	the	DET
admet-854	365	12	anti	anti	ADJ
admet-854	365	13	-	-	ADJ
admet-854	365	14	parkinsonian	parkinsonian	ADJ
admet-854	365	15	effects	effect	NOUN
admet-854	365	16	of	of	ADP
admet-854	365	17	the	the	DET
admet-854	365	18	amantadine	amantadine	NOUN
admet-854	365	19	.	.	PUNCT
admet-854	366	1	the	the	DET
admet-854	366	2	methods	method	NOUN
admet-854	366	3	used	use	VERB
admet-854	366	4	in	in	ADP
admet-854	366	5	the	the	DET
admet-854	366	6	present	present	ADJ
admet-854	366	7	study	study	NOUN
admet-854	366	8	do	do	AUX
admet-854	366	9	not	not	PART
admet-854	366	10	elucidate	elucidate	VERB
admet-854	366	11	the	the	DET
admet-854	366	12	mechanism	mechanism	NOUN
admet-854	366	13	of	of	ADP
admet-854	366	14	amantadine	amantadine	NOUN
admet-854	366	15	,	,	PUNCT
admet-854	366	16	but	but	CCONJ
admet-854	366	17	demonstrate	demonstrate	VERB
admet-854	366	18	that	that	SCONJ
admet-854	366	19	in	in	ADP
admet-854	366	20	pd	pd	PROPN
admet-854	366	21	there	there	PRON
admet-854	366	22	is	be	VERB
admet-854	366	23	a	a	DET
admet-854	366	24	link	link	NOUN
admet-854	366	25	between	between	ADP
admet-854	366	26	amantadine	amantadine	NOUN
admet-854	366	27	and	and	CCONJ
admet-854	366	28	some	some	DET
admet-854	366	29	enzymes	enzyme	NOUN
admet-854	366	30	described	describe	VERB
admet-854	366	31	to	to	PART
admet-854	366	32	be	be	AUX
admet-854	366	33	modified	modify	VERB
admet-854	366	34	in	in	ADP
admet-854	366	35	different	different	ADJ
admet-854	366	36	stages	stage	NOUN
admet-854	366	37	of	of	ADP
admet-854	366	38	the	the	DET
admet-854	366	39	disease	disease	NOUN
admet-854	366	40	.	.	PUNCT
admet-854	367	1	admet	admet	PROPN
admet-854	367	2	&	&	CCONJ
admet-854	367	3	dmpk	dmpk	PROPN
admet-854	367	4	8(2	8(2	NUM
admet-854	367	5	)	)	PUNCT
admet-854	367	6	(	(	PUNCT
admet-854	367	7	2020	2020	NUM
admet-854	367	8	)	)	PUNCT
admet-854	367	9	149	149	NUM
admet-854	367	10	-	-	SYM
admet-854	367	11	175	175	NUM
admet-854	367	12	amantadine	amantadine	NOUN
admet-854	367	13	binding	bind	VERB
admet-854	367	14	to	to	ADP
admet-854	367	15	the	the	DET
admet-854	367	16	enzymes	enzyme	NOUN
admet-854	367	17	regulated	regulate	VERB
admet-854	367	18	in	in	ADP
admet-854	367	19	parkinson	parkinson	NOUN
admet-854	367	20	’s	’s	PART
admet-854	367	21	disease	disease	NOUN
admet-854	367	22	doi	doi	NOUN
admet-854	367	23	:	:	PUNCT
admet-854	367	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	367	25	169	169	NUM
admet-854	367	26	conclusions	conclusion	NOUN
admet-854	367	27	the	the	DET
admet-854	367	28	pd	pd	PROPN
admet-854	367	29	is	be	AUX
admet-854	367	30	a	a	DET
admet-854	367	31	progressive	progressive	ADJ
admet-854	367	32	neurodegenerative	neurodegenerative	ADJ
admet-854	367	33	disease	disease	NOUN
admet-854	367	34	characterized	characterize	VERB
admet-854	367	35	mainly	mainly	ADV
admet-854	367	36	by	by	ADP
admet-854	367	37	motility	motility	NOUN
admet-854	367	38	impairment	impairment	NOUN
admet-854	367	39	.	.	PUNCT
admet-854	368	1	there	there	PRON
admet-854	368	2	is	be	VERB
admet-854	368	3	no	no	DET
admet-854	368	4	curative	curative	ADJ
admet-854	368	5	treatment	treatment	NOUN
admet-854	368	6	but	but	CCONJ
admet-854	368	7	there	there	PRON
admet-854	368	8	are	be	VERB
admet-854	368	9	some	some	DET
admet-854	368	10	therapeutic	therapeutic	ADJ
admet-854	368	11	strategies	strategy	NOUN
admet-854	368	12	for	for	ADP
admet-854	368	13	the	the	DET
admet-854	368	14	treatment	treatment	NOUN
admet-854	368	15	of	of	ADP
admet-854	368	16	dyskinesia	dyskinesia	NOUN
admet-854	368	17	,	,	PUNCT
admet-854	368	18	amantadine	amantadine	NOUN
admet-854	368	19	being	be	AUX
admet-854	368	20	used	use	VERB
admet-854	368	21	until	until	ADP
admet-854	368	22	now	now	ADV
admet-854	368	23	even	even	ADV
admet-854	368	24	for	for	ADP
admet-854	368	25	better	well	ADJ
admet-854	368	26	control	control	NOUN
admet-854	368	27	of	of	ADP
admet-854	368	28	levodopa	levodopa	NOUN
admet-854	368	29	-	-	PUNCT
admet-854	368	30	induced	induce	VERB
admet-854	368	31	dyskinesia	dyskinesia	NOUN
admet-854	368	32	.	.	PUNCT
admet-854	369	1	also	also	ADV
admet-854	369	2	,	,	PUNCT
admet-854	369	3	there	there	PRON
admet-854	369	4	is	be	VERB
admet-854	369	5	demonstrated	demonstrate	VERB
admet-854	369	6	that	that	SCONJ
admet-854	369	7	in	in	ADP
admet-854	369	8	the	the	DET
admet-854	369	9	clinical	clinical	ADJ
admet-854	369	10	evolution	evolution	NOUN
admet-854	369	11	of	of	ADP
admet-854	369	12	pd	pd	PROPN
admet-854	369	13	,	,	PUNCT
admet-854	369	14	many	many	ADJ
admet-854	369	15	enzymes	enzyme	NOUN
admet-854	369	16	are	be	AUX
admet-854	369	17	modified	modify	VERB
admet-854	369	18	some	some	DET
admet-854	369	19	ak	ak	PROPN
admet-854	369	20	isoforms	isoform	NOUN
admet-854	369	21	,	,	PUNCT
admet-854	369	22	aprt	aprt	NOUN
admet-854	369	23	,	,	PUNCT
admet-854	369	24	nt5e	nt5e	PROPN
admet-854	369	25	,	,	PUNCT
admet-854	369	26	entpd1	entpd1	NOUN
admet-854	369	27	,	,	PUNCT
admet-854	369	28	ndk3	ndk3	PROPN
admet-854	369	29	,	,	PUNCT
admet-854	369	30	and	and	CCONJ
admet-854	369	31	pnp1	pnp1	PROPN
admet-854	369	32	.	.	PUNCT
admet-854	370	1	using	use	VERB
admet-854	370	2	available	available	ADJ
admet-854	370	3	x	x	NOUN
admet-854	370	4	-	-	NOUN
admet-854	370	5	ray	ray	ADJ
admet-854	370	6	3d	3d	NOUN
admet-854	370	7	structures	structure	NOUN
admet-854	370	8	of	of	ADP
admet-854	370	9	these	these	DET
admet-854	370	10	enzymes	enzyme	NOUN
admet-854	370	11	or	or	CCONJ
admet-854	370	12	their	their	PRON
admet-854	370	13	counterparts	counterpart	NOUN
admet-854	370	14	from	from	ADP
admet-854	370	15	other	other	ADJ
admet-854	370	16	organisms	organism	NOUN
admet-854	370	17	,	,	PUNCT
admet-854	370	18	two	two	NUM
admet-854	370	19	enzymes	enzyme	NOUN
admet-854	370	20	show	show	VERB
admet-854	370	21	relevant	relevant	ADJ
admet-854	370	22	results	result	NOUN
admet-854	370	23	–	–	PUNCT
admet-854	370	24	ak	ak	NOUN
admet-854	370	25	and	and	CCONJ
admet-854	370	26	aprt	aprt	PROPN
admet-854	370	27	.	.	PUNCT
admet-854	371	1	the	the	DET
admet-854	371	2	closedconformation	closedconformation	NOUN
admet-854	371	3	of	of	ADP
admet-854	371	4	the	the	DET
admet-854	371	5	ak	ak	PROPN
admet-854	371	6	is	be	AUX
admet-854	371	7	most	most	ADV
admet-854	371	8	reliable	reliable	ADJ
admet-854	371	9	due	due	ADP
admet-854	371	10	to	to	ADP
admet-854	371	11	the	the	DET
admet-854	371	12	catalytic	catalytic	ADJ
admet-854	371	13	particularities	particularity	NOUN
admet-854	371	14	of	of	ADP
admet-854	371	15	the	the	DET
admet-854	371	16	enzyme	enzyme	NOUN
admet-854	371	17	–	–	PUNCT
admet-854	371	18	the	the	DET
admet-854	371	19	movement	movement	NOUN
admet-854	371	20	of	of	ADP
admet-854	371	21	the	the	DET
admet-854	371	22	domains	domain	NOUN
admet-854	371	23	is	be	AUX
admet-854	371	24	coordinated	coordinate	VERB
admet-854	371	25	by	by	ADP
admet-854	371	26	the	the	DET
admet-854	371	27	sequential	sequential	ADJ
admet-854	371	28	addition	addition	NOUN
admet-854	371	29	of	of	ADP
admet-854	371	30	the	the	DET
admet-854	371	31	substrates	substrate	NOUN
admet-854	371	32	.	.	PUNCT
admet-854	372	1	the	the	DET
admet-854	372	2	molecular	molecular	ADJ
admet-854	372	3	docking	docking	NOUN
admet-854	372	4	experiments	experiment	NOUN
admet-854	372	5	demonstrated	demonstrate	VERB
admet-854	372	6	that	that	SCONJ
admet-854	372	7	human	human	ADJ
admet-854	372	8	ak1	ak1	NOUN
admet-854	372	9	and	and	CCONJ
admet-854	372	10	ak2	ak2	NOUN
admet-854	372	11	with	with	ADP
admet-854	372	12	ionized	ionize	VERB
admet-854	372	13	amantadine	amantadine	NOUN
admet-854	372	14	by	by	ADP
admet-854	372	15	amp	amp	NOUN
admet-854	372	16	binding	bind	VERB
admet-854	372	17	residues	residue	NOUN
admet-854	372	18	but	but	CCONJ
admet-854	372	19	there	there	PRON
admet-854	372	20	are	be	VERB
admet-854	372	21	notable	notable	ADJ
admet-854	372	22	differences	difference	NOUN
admet-854	372	23	between	between	ADP
admet-854	372	24	the	the	DET
admet-854	372	25	two	two	NUM
admet-854	372	26	ak	ak	PROPN
admet-854	372	27	isoforms	isoform	NOUN
admet-854	372	28	.	.	PUNCT
admet-854	373	1	other	other	ADJ
admet-854	373	2	aks	ak	NOUN
admet-854	373	3	included	include	VERB
admet-854	373	4	in	in	ADP
admet-854	373	5	the	the	DET
admet-854	373	6	study	study	NOUN
admet-854	373	7	,	,	PUNCT
admet-854	373	8	further	far	ADV
admet-854	373	9	demonstrated	demonstrate	VERB
admet-854	373	10	the	the	DET
admet-854	373	11	specific	specific	ADJ
admet-854	373	12	interaction	interaction	NOUN
admet-854	373	13	of	of	ADP
admet-854	373	14	amantadine	amantadine	NOUN
admet-854	373	15	with	with	ADP
admet-854	373	16	human	human	ADJ
admet-854	373	17	aks	ak	NOUN
admet-854	373	18	.	.	PUNCT
admet-854	374	1	the	the	DET
admet-854	374	2	study	study	NOUN
admet-854	374	3	of	of	ADP
admet-854	374	4	amantadine	amantadine	NOUN
admet-854	374	5	interaction	interaction	NOUN
admet-854	374	6	with	with	ADP
admet-854	374	7	different	different	ADJ
admet-854	374	8	aks	ak	NOUN
admet-854	374	9	’	'	PUNCT
admet-854	374	10	isoforms	isoform	NOUN
admet-854	374	11	has	have	VERB
admet-854	374	12	more	more	ADJ
admet-854	374	13	to	to	PART
admet-854	374	14	give	give	VERB
admet-854	374	15	.	.	PUNCT
admet-854	375	1	the	the	DET
admet-854	375	2	studies	study	NOUN
admet-854	375	3	of	of	ADP
admet-854	375	4	the	the	DET
admet-854	375	5	pd	pd	PROPN
admet-854	375	6	highlighted	highlight	VERB
admet-854	375	7	that	that	SCONJ
admet-854	375	8	there	there	PRON
admet-854	375	9	is	be	VERB
admet-854	375	10	a	a	DET
admet-854	375	11	relationship	relationship	NOUN
admet-854	375	12	between	between	ADP
admet-854	375	13	the	the	DET
admet-854	375	14	key	key	ADJ
admet-854	375	15	factors	factor	NOUN
admet-854	375	16	involved	involve	VERB
admet-854	375	17	in	in	ADP
admet-854	375	18	pd	pd	PROPN
admet-854	375	19	.	.	PROPN
admet-854	375	20	among	among	ADP
admet-854	375	21	them	they	PRON
admet-854	375	22	,	,	PUNCT
admet-854	375	23	mitochondrial	mitochondrial	ADJ
admet-854	375	24	factors	factor	NOUN
admet-854	375	25	have	have	VERB
admet-854	375	26	a	a	DET
admet-854	375	27	crucial	crucial	ADJ
admet-854	375	28	role	role	NOUN
admet-854	375	29	in	in	ADP
admet-854	375	30	the	the	DET
admet-854	375	31	disease	disease	NOUN
admet-854	375	32	pathogenesis	pathogenesis	NOUN
admet-854	375	33	.	.	PUNCT
admet-854	376	1	the	the	DET
admet-854	376	2	aprt	aprt	PROPN
admet-854	376	3	structures	structure	NOUN
admet-854	376	4	co	co	VERB
admet-854	376	5	-	-	VERB
admet-854	376	6	crystallized	crystallize	VERB
admet-854	376	7	with	with	ADP
admet-854	376	8	amp	amp	PROPN
admet-854	376	9	results	result	NOUN
admet-854	376	10	in	in	ADP
admet-854	376	11	the	the	DET
admet-854	376	12	best	good	ADJ
admet-854	376	13	interactions	interaction	NOUN
admet-854	376	14	with	with	ADP
admet-854	376	15	amantadine	amantadine	NOUN
admet-854	376	16	,	,	PUNCT
admet-854	376	17	the	the	DET
admet-854	376	18	amp	amp	NOUN
admet-854	376	19	-	-	PUNCT
admet-854	376	20	binding	bind	VERB
admet-854	376	21	residues	residue	NOUN
admet-854	376	22	form	form	VERB
admet-854	376	23	strong	strong	ADJ
admet-854	376	24	interactions	interaction	NOUN
admet-854	376	25	with	with	ADP
admet-854	376	26	amantadine	amantadine	NOUN
admet-854	376	27	.	.	PUNCT
admet-854	377	1	the	the	DET
admet-854	377	2	results	result	NOUN
admet-854	377	3	of	of	ADP
admet-854	377	4	the	the	DET
admet-854	377	5	present	present	ADJ
admet-854	377	6	study	study	NOUN
admet-854	377	7	offer	offer	VERB
admet-854	377	8	a	a	DET
admet-854	377	9	new	new	ADJ
admet-854	377	10	perspective	perspective	NOUN
admet-854	377	11	for	for	ADP
admet-854	377	12	further	further	ADJ
admet-854	377	13	investigation	investigation	NOUN
admet-854	377	14	of	of	ADP
admet-854	377	15	the	the	DET
admet-854	377	16	connections	connection	NOUN
admet-854	377	17	between	between	ADP
admet-854	377	18	amantadine	amantadine	NOUN
admet-854	377	19	treatment	treatment	NOUN
admet-854	377	20	of	of	ADP
admet-854	377	21	pd	pd	PROPN
admet-854	377	22	and	and	CCONJ
admet-854	377	23	some	some	DET
admet-854	377	24	enzymes	enzyme	NOUN
admet-854	377	25	involved	involve	VERB
admet-854	377	26	in	in	ADP
admet-854	377	27	purine	purine	NOUN
admet-854	377	28	metabolism	metabolism	NOUN
admet-854	377	29	.	.	PUNCT
admet-854	378	1	funding	funding	NOUN
admet-854	378	2	:	:	PUNCT
admet-854	378	3	this	this	DET
admet-854	378	4	work	work	NOUN
admet-854	378	5	was	be	AUX
admet-854	378	6	supported	support	VERB
admet-854	378	7	by	by	ADP
admet-854	378	8	a	a	DET
admet-854	378	9	grant	grant	NOUN
admet-854	378	10	of	of	ADP
admet-854	378	11	ministry	ministry	PROPN
admet-854	378	12	of	of	ADP
admet-854	378	13	research	research	NOUN
admet-854	378	14	and	and	CCONJ
admet-854	378	15	innovation	innovation	NOUN
admet-854	378	16	,	,	PUNCT
admet-854	378	17	cncs	cncs	PROPN
admet-854	378	18	uefiscdi	uefiscdi	NOUN
admet-854	378	19	,	,	PUNCT
admet-854	378	20	project	project	NOUN
admet-854	378	21	number	number	NOUN
admet-854	378	22	pn	pn	PROPN
admet-854	378	23	-	-	PUNCT
admet-854	378	24	iiip4	iiip4	NOUN
admet-854	378	25	-	-	PUNCT
admet-854	378	26	id	id	ADP
admet-854	378	27	-	-	PUNCT
admet-854	378	28	pccf-2016	pccf-2016	NOUN
admet-854	378	29	-	-	PUNCT
admet-854	378	30	0016	0016	NUM
admet-854	378	31	,	,	PUNCT
admet-854	378	32	within	within	ADP
admet-854	378	33	pncdi	pncdi	NOUN
admet-854	378	34	iii	iii	NOUN
admet-854	378	35	and	and	CCONJ
admet-854	378	36	by	by	ADP
admet-854	378	37	a	a	DET
admet-854	378	38	mobility	mobility	NOUN
admet-854	378	39	project	project	NOUN
admet-854	378	40	of	of	ADP
admet-854	378	41	the	the	DET
admet-854	378	42	romanian	romanian	PROPN
admet-854	378	43	ministry	ministry	PROPN
admet-854	378	44	of	of	ADP
admet-854	378	45	research	research	NOUN
admet-854	378	46	and	and	CCONJ
admet-854	378	47	innovation	innovation	NOUN
admet-854	378	48	,	,	PUNCT
admet-854	378	49	cncs	cncs	PROPN
admet-854	378	50	uefiscdi	uefiscdi	PROPN
admet-854	378	51	,	,	PUNCT
admet-854	378	52	the	the	DET
admet-854	378	53	project	project	NOUN
admet-854	378	54	number	number	NOUN
admet-854	378	55	pn	pn	PROPN
admet-854	378	56	-	-	PUNCT
admet-854	378	57	iii	iii	NOUN
admet-854	378	58	-	-	PUNCT
admet-854	378	59	p1	p1	NOUN
admet-854	378	60	-	-	PUNCT
admet-854	378	61	1.1	1.1	NUM
admet-854	378	62	-	-	PUNCT
admet-854	378	63	mcd-2018	mcd-2018	NOUN
admet-854	378	64	-	-	PUNCT
admet-854	378	65	0108	0108	NUM
admet-854	378	66	,	,	PUNCT
admet-854	378	67	within	within	ADP
admet-854	378	68	pncdi	pncdi	PROPN
admet-854	378	69	iii	iii	PROPN
admet-854	378	70	.	.	PUNCT
admet-854	378	71	acknowledgements	acknowledgement	NOUN
admet-854	378	72	:	:	PUNCT
admet-854	378	73	this	this	DET
admet-854	378	74	work	work	NOUN
admet-854	378	75	is	be	AUX
admet-854	378	76	dedicated	dedicate	VERB
admet-854	378	77	to	to	ADP
admet-854	378	78	the	the	DET
admet-854	378	79	memory	memory	NOUN
admet-854	378	80	of	of	ADP
admet-854	378	81	professor	professor	PROPN
admet-854	378	82	dr	dr	PROPN
admet-854	378	83	.	.	PROPN
admet-854	378	84	octavian	octavian	PROPN
admet-854	378	85	bârzu	bârzu	PROPN
admet-854	378	86	,	,	PUNCT
admet-854	378	87	my	my	PRON
admet-854	378	88	mentor	mentor	NOUN
admet-854	378	89	in	in	ADP
admet-854	378	90	the	the	DET
admet-854	378	91	study	study	NOUN
admet-854	378	92	of	of	ADP
admet-854	378	93	nucleoside	nucleoside	ADJ
admet-854	378	94	monophosphate	monophosphate	NOUN
admet-854	378	95	kinases	kinase	NOUN
admet-854	378	96	.	.	PUNCT
admet-854	379	1	i	i	PRON
admet-854	379	2	would	would	AUX
admet-854	379	3	like	like	VERB
admet-854	379	4	to	to	PART
admet-854	379	5	thank	thank	VERB
admet-854	379	6	tudor	tudor	PROPN
admet-854	379	7	constantin	constantin	PROPN
admet-854	379	8	badea	badea	PROPN
admet-854	379	9	for	for	ADP
admet-854	379	10	his	his	PRON
admet-854	379	11	generous	generous	ADJ
admet-854	379	12	advice	advice	NOUN
admet-854	379	13	during	during	ADP
admet-854	379	14	the	the	DET
admet-854	379	15	mobility	mobility	NOUN
admet-854	379	16	project	project	NOUN
admet-854	379	17	.	.	PUNCT
admet-854	380	1	many	many	ADJ
admet-854	380	2	thanks	thank	NOUN
admet-854	380	3	to	to	ADP
admet-854	380	4	the	the	DET
admet-854	380	5	reviewers	reviewer	NOUN
admet-854	380	6	for	for	ADP
admet-854	380	7	their	their	PRON
admet-854	380	8	generous	generous	ADJ
admet-854	380	9	comments	comment	NOUN
admet-854	380	10	.	.	PUNCT
admet-854	381	1	conflicts	conflict	NOUN
admet-854	381	2	of	of	ADP
admet-854	381	3	interest	interest	NOUN
admet-854	381	4	:	:	PUNCT
admet-854	381	5	the	the	DET
admet-854	381	6	authors	author	NOUN
admet-854	381	7	declare	declare	VERB
admet-854	381	8	no	no	DET
admet-854	381	9	conflict	conflict	NOUN
admet-854	381	10	of	of	ADP
admet-854	381	11	interest	interest	NOUN
admet-854	381	12	.	.	PUNCT
admet-854	382	1	the	the	DET
admet-854	382	2	funders	funder	NOUN
admet-854	382	3	had	have	VERB
admet-854	382	4	no	no	DET
admet-854	382	5	role	role	NOUN
admet-854	382	6	in	in	ADP
admet-854	382	7	the	the	DET
admet-854	382	8	design	design	NOUN
admet-854	382	9	of	of	ADP
admet-854	382	10	the	the	DET
admet-854	382	11	study	study	NOUN
admet-854	382	12	;	;	PUNCT
admet-854	382	13	in	in	ADP
admet-854	382	14	the	the	DET
admet-854	382	15	collection	collection	NOUN
admet-854	382	16	,	,	PUNCT
admet-854	382	17	analyses	analysis	NOUN
admet-854	382	18	,	,	PUNCT
admet-854	382	19	or	or	CCONJ
admet-854	382	20	interpretation	interpretation	NOUN
admet-854	382	21	of	of	ADP
admet-854	382	22	data	datum	NOUN
admet-854	382	23	;	;	PUNCT
admet-854	382	24	in	in	ADP
admet-854	382	25	the	the	DET
admet-854	382	26	writing	writing	NOUN
admet-854	382	27	of	of	ADP
admet-854	382	28	the	the	DET
admet-854	382	29	manuscript	manuscript	NOUN
admet-854	382	30	,	,	PUNCT
admet-854	382	31	or	or	CCONJ
admet-854	382	32	in	in	ADP
admet-854	382	33	the	the	DET
admet-854	382	34	decision	decision	NOUN
admet-854	382	35	to	to	PART
admet-854	382	36	publish	publish	VERB
admet-854	382	37	the	the	DET
admet-854	382	38	results	result	NOUN
admet-854	382	39	.	.	PUNCT
admet-854	383	1	references	reference	NOUN
admet-854	383	2	[	[	X
admet-854	383	3	1	1	NUM
admet-854	383	4	]	]	X
admet-854	383	5	d.j	d.j	PROPN
admet-854	383	6	.	.	PROPN
admet-854	383	7	gelb	gelb	PROPN
admet-854	383	8	,	,	PUNCT
admet-854	383	9	e.	e.	PROPN
admet-854	383	10	oliver	oliver	PROPN
admet-854	383	11	,	,	PUNCT
admet-854	383	12	s.	s.	PROPN
admet-854	383	13	gilman	gilman	PROPN
admet-854	383	14	.	.	PUNCT
admet-854	384	1	diagnostic	diagnostic	ADJ
admet-854	384	2	criteria	criterion	NOUN
admet-854	384	3	for	for	ADP
admet-854	384	4	parkinson	parkinson	NOUN
admet-854	384	5	disease	disease	NOUN
admet-854	384	6	.	.	PUNCT
admet-854	385	1	arch	arch	NOUN
admet-854	385	2	.	.	PUNCT
admet-854	386	1	neurol	neurol	NOUN
admet-854	386	2	.	.	PUNCT
admet-854	387	1	56	56	NUM
admet-854	387	2	(	(	PUNCT
admet-854	387	3	1999	1999	NUM
admet-854	387	4	)	)	PUNCT
admet-854	387	5	3339	3339	NUM
admet-854	387	6	.	.	PUNCT
admet-854	388	1	[	[	X
admet-854	388	2	2	2	X
admet-854	388	3	]	]	PUNCT
admet-854	388	4	j.	j.	PROPN
admet-854	388	5	jankovic	jankovic	PROPN
admet-854	388	6	.	.	PUNCT
admet-854	388	7	parkinson	parkinson	PROPN
admet-854	388	8	's	's	PART
admet-854	388	9	disease	disease	NOUN
admet-854	388	10	:	:	PUNCT
admet-854	388	11	clinical	clinical	ADJ
admet-854	388	12	features	feature	NOUN
admet-854	388	13	and	and	CCONJ
admet-854	388	14	diagnosis	diagnosis	NOUN
admet-854	388	15	.	.	PUNCT
admet-854	389	1	j.	j.	PROPN
admet-854	389	2	neurol	neurol	PROPN
admet-854	389	3	.	.	PUNCT
admet-854	390	1	neurosurg	neurosurg	PROPN
admet-854	390	2	.	.	PUNCT
admet-854	391	1	psychiatry	psychiatry	NOUN
admet-854	391	2	79	79	NUM
admet-854	391	3	(	(	PUNCT
admet-854	391	4	2008	2008	NUM
admet-854	391	5	)	)	PUNCT
admet-854	391	6	368	368	NUM
admet-854	391	7	-	-	SYM
admet-854	391	8	376	376	NUM
admet-854	391	9	.	.	PUNCT
admet-854	392	1	[	[	X
admet-854	392	2	3	3	NUM
admet-854	392	3	]	]	X
admet-854	392	4	f.	f.	PROPN
admet-854	392	5	sun	sun	PROPN
admet-854	392	6	,	,	PUNCT
admet-854	392	7	y.	y.	PROPN
admet-854	392	8	deng	deng	PROPN
admet-854	392	9	,	,	PUNCT
admet-854	392	10	x.	x.	PROPN
admet-854	392	11	han	han	PROPN
admet-854	392	12	,	,	PUNCT
admet-854	392	13	q.	q.	PROPN
admet-854	392	14	liu	liu	PROPN
admet-854	392	15	,	,	PUNCT
admet-854	392	16	p.	p.	PROPN
admet-854	392	17	zhang	zhang	PROPN
admet-854	392	18	,	,	PUNCT
admet-854	392	19	r.	r.	PROPN
admet-854	392	20	manzoor	manzoor	PROPN
admet-854	392	21	,	,	PUNCT
admet-854	392	22	h.	h.	PROPN
admet-854	392	23	ma	ma	PROPN
admet-854	392	24	.	.	PROPN
admet-854	393	1	a	a	DET
admet-854	393	2	secret	secret	NOUN
admet-854	393	3	that	that	PRON
admet-854	393	4	underlies	underlie	VERB
admet-854	393	5	parkinson	parkinson	NOUN
admet-854	393	6	's	's	PART
admet-854	393	7	disease	disease	NOUN
admet-854	393	8	:	:	PUNCT
admet-854	393	9	the	the	DET
admet-854	393	10	damaging	damaging	ADJ
admet-854	393	11	cycle	cycle	NOUN
admet-854	393	12	.	.	PUNCT
admet-854	394	1	neurochem	neurochem	PROPN
admet-854	394	2	.	.	PUNCT
admet-854	395	1	int	int	NOUN
admet-854	395	2	.	.	PUNCT
admet-854	396	1	129	129	NUM
admet-854	396	2	(	(	PUNCT
admet-854	396	3	2019	2019	NUM
admet-854	396	4	)	)	PUNCT
admet-854	396	5	104484	104484	NUM
admet-854	396	6	.	.	PUNCT
admet-854	397	1	[	[	X
admet-854	397	2	4	4	X
admet-854	397	3	]	]	X
admet-854	397	4	b.	b.	PROPN
admet-854	397	5	boland	boland	PROPN
admet-854	397	6	,	,	PUNCT
admet-854	397	7	f.m	f.m	PROPN
admet-854	397	8	.	.	PROPN
admet-854	397	9	platt	platt	NOUN
admet-854	397	10	.	.	PUNCT
admet-854	398	1	bridging	bridge	VERB
admet-854	398	2	the	the	DET
admet-854	398	3	age	age	NOUN
admet-854	398	4	spectrum	spectrum	NOUN
admet-854	398	5	of	of	ADP
admet-854	398	6	neurodegenerative	neurodegenerative	ADJ
admet-854	398	7	storage	storage	NOUN
admet-854	398	8	diseases	disease	NOUN
admet-854	398	9	.	.	PUNCT
admet-854	399	1	best	good	ADJ
admet-854	399	2	pract	pract	PROPN
admet-854	399	3	.	.	PUNCT
admet-854	400	1	res	re	NOUN
admet-854	400	2	.	.	PUNCT
admet-854	401	1	clin	clin	PROPN
admet-854	401	2	.	.	PUNCT
admet-854	401	3	endocrinol	endocrinol	NOUN
admet-854	401	4	.	.	PUNCT
admet-854	402	1	metab	metab	PROPN
admet-854	402	2	.	.	PUNCT
admet-854	403	1	29	29	NUM
admet-854	403	2	(	(	PUNCT
admet-854	403	3	2015	2015	NUM
admet-854	403	4	)	)	PUNCT
admet-854	403	5	127	127	NUM
admet-854	403	6	-	-	SYM
admet-854	403	7	143	143	NUM
admet-854	403	8	[	[	X
admet-854	403	9	5	5	NUM
admet-854	403	10	]	]	PUNCT
admet-854	403	11	d.	d.	PROPN
admet-854	403	12	elstein	elstein	PROPN
admet-854	403	13	,	,	PUNCT
admet-854	403	14	r.	r.	PROPN
admet-854	403	15	alcalay	alcalay	PROPN
admet-854	403	16	,	,	PUNCT
admet-854	403	17	a.	a.	NOUN
admet-854	403	18	zimran	zimran	PROPN
admet-854	403	19	.	.	PUNCT
admet-854	404	1	the	the	DET
admet-854	404	2	emergence	emergence	NOUN
admet-854	404	3	of	of	ADP
admet-854	404	4	parkinson	parkinson	NOUN
admet-854	404	5	disease	disease	NOUN
admet-854	404	6	among	among	ADP
admet-854	404	7	patients	patient	NOUN
admet-854	404	8	with	with	ADP
admet-854	404	9	gaucher	gaucher	PROPN
admet-854	404	10	disease	disease	PROPN
admet-854	404	11	.	.	PUNCT
admet-854	405	1	best	good	ADJ
admet-854	405	2	pract	pract	PROPN
admet-854	405	3	.	.	PUNCT
admet-854	406	1	res	re	NOUN
admet-854	406	2	.	.	PUNCT
admet-854	407	1	clin	clin	PROPN
admet-854	407	2	.	.	PUNCT
admet-854	407	3	endocrinol	endocrinol	NOUN
admet-854	407	4	.	.	PUNCT
admet-854	408	1	metab	metab	PROPN
admet-854	408	2	.	.	PUNCT
admet-854	409	1	29	29	NUM
admet-854	409	2	(	(	PUNCT
admet-854	409	3	2015	2015	NUM
admet-854	409	4	)	)	PUNCT
admet-854	409	5	249	249	NUM
admet-854	409	6	-	-	SYM
admet-854	409	7	259	259	NUM
admet-854	409	8	.	.	PUNCT
admet-854	410	1	[	[	X
admet-854	410	2	6	6	NUM
admet-854	410	3	]	]	X
admet-854	410	4	e.	e.	PROPN
admet-854	410	5	bezard	bezard	PROPN
admet-854	410	6	,	,	PUNCT
admet-854	410	7	c.e	c.e	PROPN
admet-854	410	8	.	.	PROPN
admet-854	410	9	gross	gross	PROPN
admet-854	410	10	,	,	PUNCT
admet-854	410	11	m.c	m.c	PROPN
admet-854	410	12	.	.	PROPN
admet-854	410	13	fournier	fournier	PROPN
admet-854	410	14	,	,	PUNCT
admet-854	410	15	s.	s.	PROPN
admet-854	410	16	dovero	dovero	PROPN
admet-854	410	17	,	,	PUNCT
admet-854	410	18	b.	b.	PROPN
admet-854	410	19	bloch	bloch	PROPN
admet-854	410	20	,	,	PUNCT
admet-854	410	21	m.	m.	PROPN
admet-854	410	22	jaber	jaber	PROPN
admet-854	410	23	.	.	PUNCT
admet-854	411	1	absence	absence	NOUN
admet-854	411	2	of	of	ADP
admet-854	411	3	mptp	mptp	PROPN
admet-854	411	4	-	-	ADJ
admet-854	411	5	induced	induce	VERB
admet-854	411	6	neuronal	neuronal	ADJ
admet-854	411	7	death	death	NOUN
admet-854	411	8	in	in	ADP
admet-854	411	9	mice	mouse	NOUN
admet-854	411	10	lacking	lack	VERB
admet-854	411	11	the	the	DET
admet-854	411	12	dopamine	dopamine	NOUN
admet-854	411	13	transporter	transporter	NOUN
admet-854	411	14	.	.	PUNCT
admet-854	412	1	exp	exp	NOUN
admet-854	412	2	.	.	PUNCT
admet-854	413	1	neurol	neurol	PROPN
admet-854	413	2	.	.	PUNCT
admet-854	414	1	155	155	NUM
admet-854	414	2	(	(	PUNCT
admet-854	414	3	1999	1999	NUM
admet-854	414	4	)	)	PUNCT
admet-854	414	5	268	268	NUM
admet-854	414	6	-	-	SYM
admet-854	414	7	273	273	NUM
admet-854	414	8	.	.	PUNCT
admet-854	415	1	[	[	X
admet-854	415	2	7	7	NUM
admet-854	415	3	]	]	X
admet-854	415	4	z.r	z.r	PROPN
admet-854	415	5	.	.	PROPN
admet-854	415	6	zhang	zhang	PROPN
admet-854	415	7	,	,	PUNCT
admet-854	415	8	x.r	x.r	PROPN
admet-854	415	9	.	.	PUNCT
admet-854	415	10	zhang	zhang	PROPN
admet-854	415	11	,	,	PUNCT
admet-854	415	12	x.q	x.q	PROPN
admet-854	415	13	.	.	PROPN
admet-854	415	14	luan	luan	PROPN
admet-854	415	15	,	,	PUNCT
admet-854	416	1	x.s	x.s	PROPN
admet-854	416	2	.	.	PROPN
admet-854	416	3	wang	wang	PROPN
admet-854	416	4	,	,	PUNCT
admet-854	416	5	w.w	w.w	PROPN
admet-854	416	6	.	.	PROPN
admet-854	416	7	wang	wang	PROPN
admet-854	416	8	,	,	PUNCT
admet-854	416	9	x.y	x.y	PROPN
admet-854	416	10	.	.	PROPN
admet-854	416	11	wang	wang	PROPN
admet-854	416	12	,	,	PUNCT
admet-854	416	13	b.	b.	PROPN
admet-854	416	14	shao	shao	PROPN
admet-854	416	15	,	,	PUNCT
admet-854	416	16	c.l	c.l	PROPN
admet-854	416	17	.	.	PROPN
admet-854	416	18	xie	xie	PROPN
admet-854	416	19	.	.	PUNCT
admet-854	417	1	striatal	striatal	ADJ
admet-854	417	2	overexpression	overexpression	NOUN
admet-854	417	3	of	of	ADP
admet-854	417	4	β	β	NOUN
admet-854	417	5	-	-	ADJ
admet-854	417	6	arrestin2	arrestin2	NOUN
admet-854	417	7	counteracts	counteract	VERB
admet-854	417	8	l	l	NOUN
admet-854	417	9	-	-	PUNCT
admet-854	417	10	dopa	dopa	NOUN
admet-854	417	11	-	-	PUNCT
admet-854	417	12	induced	induce	VERB
admet-854	417	13	dyskinesia	dyskinesia	NOUN
admet-854	417	14	in	in	ADP
admet-854	417	15	6	6	NUM
admet-854	417	16	-	-	PUNCT
admet-854	417	17	hydroxydopamine	hydroxydopamine	NOUN
admet-854	417	18	lesioned	lesione	VERB
admet-854	417	19	parkinson	parkinson	NOUN
admet-854	417	20	's	's	PART
admet-854	417	21	disease	disease	NOUN
admet-854	417	22	rats	rat	NOUN
admet-854	417	23	.	.	PUNCT
admet-854	418	1	neurochem	neurochem	PROPN
admet-854	418	2	.	.	PUNCT
admet-854	419	1	int	int	NOUN
admet-854	419	2	.	.	PUNCT
admet-854	420	1	131	131	NUM
admet-854	420	2	(	(	PUNCT
admet-854	420	3	2019	2019	NUM
admet-854	420	4	)	)	PUNCT
admet-854	420	5	104543	104543	NUM
admet-854	420	6	.	.	PUNCT
admet-854	421	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	421	2	mihaela	mihaela	PROPN
admet-854	421	3	ileana	ileana	PROPN
admet-854	421	4	ionescu	ionescu	PROPN
admet-854	421	5	admet	admet	PROPN
admet-854	421	6	&	&	CCONJ
admet-854	421	7	dmpk	dmpk	PROPN
admet-854	421	8	8(2	8(2	NUM
admet-854	421	9	)	)	PUNCT
admet-854	421	10	(	(	PUNCT
admet-854	421	11	2020	2020	NUM
admet-854	421	12	)	)	PUNCT
admet-854	421	13	149	149	NUM
admet-854	421	14	-	-	SYM
admet-854	421	15	175	175	NUM
admet-854	421	16	170	170	NUM
admet-854	421	17	[	[	X
admet-854	421	18	8	8	NUM
admet-854	421	19	]	]	X
admet-854	421	20	g.	g.	PROPN
admet-854	421	21	orlando	orlando	PROPN
admet-854	421	22	,	,	PUNCT
admet-854	421	23	a.	a.	PROPN
admet-854	421	24	chiavaroli	chiavaroli	PROPN
admet-854	421	25	,	,	PUNCT
admet-854	421	26	s.	s.	PROPN
admet-854	421	27	leone	leone	PROPN
admet-854	421	28	,	,	PUNCT
admet-854	421	29	l.	l.	PROPN
admet-854	421	30	brunetti	brunetti	PROPN
admet-854	421	31	,	,	PUNCT
admet-854	421	32	m.	m.	NOUN
admet-854	421	33	politi	politi	PROPN
admet-854	421	34	,	,	PUNCT
admet-854	421	35	l.	l.	PROPN
admet-854	421	36	menghini	menghini	PROPN
admet-854	421	37	,	,	PUNCT
admet-854	421	38	l.	l.	PROPN
admet-854	421	39	recinella	recinella	PROPN
admet-854	421	40	,	,	PUNCT
admet-854	421	41	c.	c.	PROPN
admet-854	421	42	ferrante	ferrante	PROPN
admet-854	421	43	.	.	PUNCT
admet-854	422	1	inhibitory	inhibitory	ADJ
admet-854	422	2	effects	effect	NOUN
admet-854	422	3	induced	induce	VERB
admet-854	422	4	by	by	ADP
admet-854	422	5	vicia	vicia	PROPN
admet-854	422	6	faba	faba	PROPN
admet-854	422	7	,	,	PUNCT
admet-854	422	8	uncaria	uncaria	PROPN
admet-854	422	9	rhyncophylla	rhyncophylla	NOUN
admet-854	422	10	,	,	PUNCT
admet-854	422	11	and	and	CCONJ
admet-854	422	12	glycyrrhiza	glycyrrhiza	VERB
admet-854	422	13	glabra	glabra	NOUN
admet-854	422	14	water	water	NOUN
admet-854	422	15	extracts	extract	NOUN
admet-854	422	16	on	on	ADP
admet-854	422	17	oxidative	oxidative	ADJ
admet-854	422	18	stress	stress	NOUN
admet-854	422	19	biomarkers	biomarker	NOUN
admet-854	422	20	and	and	CCONJ
admet-854	422	21	dopamine	dopamine	NOUN
admet-854	422	22	turnover	turnover	NOUN
admet-854	422	23	in	in	ADP
admet-854	422	24	hypoe22	hypoe22	NOUN
admet-854	422	25	cells	cell	NOUN
admet-854	422	26	and	and	CCONJ
admet-854	422	27	isolated	isolate	VERB
admet-854	422	28	rat	rat	NOUN
admet-854	422	29	striatum	striatum	NOUN
admet-854	422	30	challenged	challenge	VERB
admet-854	422	31	with	with	ADP
admet-854	422	32	6	6	NUM
admet-854	422	33	-	-	PUNCT
admet-854	422	34	hydroxydopamine	hydroxydopamine	NOUN
admet-854	422	35	.	.	PUNCT
admet-854	423	1	antioxidants	antioxidant	NOUN
admet-854	423	2	(	(	PUNCT
admet-854	423	3	basel	basel	PROPN
admet-854	423	4	)	)	PUNCT
admet-854	423	5	8	8	NUM
admet-854	423	6	(	(	PUNCT
admet-854	423	7	2019	2019	NUM
admet-854	423	8	)	)	PUNCT
admet-854	424	1	e602	e602	PROPN
admet-854	424	2	.	.	PUNCT
admet-854	425	1	[	[	X
admet-854	425	2	9	9	NUM
admet-854	425	3	]	]	X
admet-854	425	4	v.	v.	CCONJ
admet-854	425	5	leta	leta	PROPN
admet-854	425	6	,	,	PUNCT
admet-854	425	7	p.	p.	PROPN
admet-854	425	8	jenner	jenner	PROPN
admet-854	425	9	,	,	PUNCT
admet-854	425	10	k.r	k.r	PROPN
admet-854	425	11	.	.	PROPN
admet-854	425	12	chaudhuri	chaudhuri	PROPN
admet-854	425	13	,	,	PUNCT
admet-854	425	14	a.	a.	PROPN
admet-854	425	15	antonini	antonini	PROPN
admet-854	425	16	.	.	PUNCT
admet-854	426	1	can	can	AUX
admet-854	426	2	therapeutic	therapeutic	ADJ
admet-854	426	3	strategies	strategy	NOUN
admet-854	426	4	prevent	prevent	VERB
admet-854	426	5	and	and	CCONJ
admet-854	426	6	manage	manage	VERB
admet-854	426	7	dyskinesia	dyskinesia	NOUN
admet-854	426	8	in	in	ADP
admet-854	426	9	parkinson	parkinson	NOUN
admet-854	426	10	's	's	PART
admet-854	426	11	disease	disease	NOUN
admet-854	426	12	?	?	PUNCT
admet-854	427	1	an	an	DET
admet-854	427	2	update	update	NOUN
admet-854	427	3	.	.	PUNCT
admet-854	428	1	expert	expert	NOUN
admet-854	428	2	opin	opin	NOUN
admet-854	428	3	.	.	PUNCT
admet-854	429	1	drug	drug	PROPN
admet-854	429	2	saf	saf	PROPN
admet-854	429	3	.	.	PROPN
admet-854	429	4	18	18	NUM
admet-854	429	5	(	(	PUNCT
admet-854	429	6	2019	2019	NUM
admet-854	429	7	)	)	PUNCT
admet-854	429	8	1203	1203	NUM
admet-854	429	9	-	-	SYM
admet-854	429	10	1218	1218	NUM
admet-854	429	11	.	.	PUNCT
admet-854	430	1	[	[	X
admet-854	430	2	10	10	NUM
admet-854	430	3	]	]	X
admet-854	430	4	b.s	b.s	PROPN
admet-854	430	5	.	.	PROPN
admet-854	430	6	connolly	connolly	PROPN
admet-854	430	7	,	,	PUNCT
admet-854	430	8	a.e	a.e	PROPN
admet-854	430	9	.	.	PROPN
admet-854	430	10	lang	lang	PROPN
admet-854	430	11	.	.	PUNCT
admet-854	431	1	pharmacological	pharmacological	ADJ
admet-854	431	2	treatment	treatment	NOUN
admet-854	431	3	of	of	ADP
admet-854	431	4	parkinson	parkinson	NOUN
admet-854	431	5	disease	disease	NOUN
admet-854	431	6	:	:	PUNCT
admet-854	431	7	a	a	DET
admet-854	431	8	review	review	NOUN
admet-854	431	9	.	.	PUNCT
admet-854	432	1	jama	jama	PROPN
admet-854	432	2	311	311	NUM
admet-854	432	3	(	(	PUNCT
admet-854	432	4	2014	2014	NUM
admet-854	432	5	)	)	PUNCT
admet-854	432	6	1670	1670	NUM
admet-854	432	7	-	-	SYM
admet-854	432	8	1683	1683	NUM
admet-854	432	9	.	.	PUNCT
admet-854	433	1	[	[	X
admet-854	433	2	11	11	NUM
admet-854	433	3	]	]	PUNCT
admet-854	433	4	w.	w.	PROPN
admet-854	433	5	oertel	oertel	PROPN
admet-854	433	6	,	,	PUNCT
admet-854	433	7	j.b	j.b	PROPN
admet-854	433	8	.	.	PUNCT
admet-854	433	9	schulz	schulz	PROPN
admet-854	433	10	.	.	PUNCT
admet-854	434	1	current	current	ADJ
admet-854	434	2	and	and	CCONJ
admet-854	434	3	experimental	experimental	ADJ
admet-854	434	4	treatments	treatment	NOUN
admet-854	434	5	of	of	ADP
admet-854	434	6	parkinson	parkinson	NOUN
admet-854	434	7	disease	disease	NOUN
admet-854	434	8	:	:	PUNCT
admet-854	434	9	a	a	DET
admet-854	434	10	guide	guide	NOUN
admet-854	434	11	for	for	ADP
admet-854	434	12	neuroscientists	neuroscientist	NOUN
admet-854	434	13	.	.	PUNCT
admet-854	435	1	j.	j.	PROPN
admet-854	435	2	neurochem	neurochem	PROPN
admet-854	435	3	.	.	PUNCT
admet-854	436	1	139	139	NUM
admet-854	436	2	suppl	suppl	ADJ
admet-854	436	3	1	1	NUM
admet-854	436	4	(	(	PUNCT
admet-854	436	5	2016	2016	NUM
admet-854	436	6	)	)	PUNCT
admet-854	436	7	325	325	NUM
admet-854	436	8	-	-	SYM
admet-854	436	9	337	337	NUM
admet-854	436	10	.	.	PUNCT
admet-854	437	1	[	[	X
admet-854	437	2	12	12	NUM
admet-854	437	3	]	]	X
admet-854	437	4	h.h	h.h	PROPN
admet-854	437	5	.	.	PROPN
admet-854	437	6	liu	liu	PROPN
admet-854	437	7	,	,	PUNCT
admet-854	437	8	n.c	n.c	PROPN
admet-854	437	9	.	.	PROPN
admet-854	437	10	yeh	yeh	PROPN
admet-854	437	11	,	,	PUNCT
admet-854	437	12	y.f	y.f	PROPN
admet-854	437	13	.	.	PUNCT
admet-854	437	14	wu	wu	PROPN
admet-854	437	15	,	,	PUNCT
admet-854	437	16	y.r	y.r	PROPN
admet-854	437	17	.	.	PROPN
admet-854	437	18	yang	yang	PROPN
admet-854	437	19	,	,	PUNCT
admet-854	437	20	r.y	r.y	PROPN
admet-854	437	21	.	.	PROPN
admet-854	437	22	wang	wang	PROPN
admet-854	437	23	,	,	PUNCT
admet-854	437	24	f.y	f.y	PROPN
admet-854	437	25	.	.	PROPN
admet-854	437	26	cheng	cheng	PROPN
admet-854	437	27	.	.	PUNCT
admet-854	438	1	effects	effect	NOUN
admet-854	438	2	of	of	ADP
admet-854	438	3	tai	tai	PROPN
admet-854	438	4	chi	chi	PROPN
admet-854	438	5	exercise	exercise	VERB
admet-854	438	6	on	on	ADP
admet-854	438	7	reducing	reduce	VERB
admet-854	438	8	falls	fall	NOUN
admet-854	438	9	and	and	CCONJ
admet-854	438	10	improving	improve	VERB
admet-854	438	11	balance	balance	NOUN
admet-854	438	12	performance	performance	NOUN
admet-854	438	13	in	in	ADP
admet-854	438	14	parkinson	parkinson	NOUN
admet-854	438	15	's	's	PART
admet-854	438	16	disease	disease	NOUN
admet-854	438	17	:	:	PUNCT
admet-854	438	18	a	a	DET
admet-854	438	19	meta	meta	ADJ
admet-854	438	20	-	-	PUNCT
admet-854	438	21	analysis	analysis	NOUN
admet-854	438	22	.	.	PUNCT
admet-854	439	1	parkinsons	parkinson	NOUN
admet-854	439	2	dis	dis	PROPN
admet-854	439	3	.	.	PUNCT
admet-854	440	1	2019	2019	NUM
admet-854	440	2	(	(	PUNCT
admet-854	440	3	2019	2019	NUM
admet-854	440	4	)	)	PUNCT
admet-854	440	5	9626934	9626934	NUM
admet-854	440	6	.	.	PUNCT
admet-854	441	1	[	[	X
admet-854	441	2	13	13	NUM
admet-854	441	3	]	]	X
admet-854	441	4	s.	s.	PROPN
admet-854	441	5	vasudevan	vasudevan	PROPN
admet-854	441	6	,	,	PUNCT
admet-854	441	7	j.	j.	PROPN
admet-854	441	8	kajtez	kajtez	PROPN
admet-854	441	9	,	,	PUNCT
admet-854	441	10	a.i	a.i	PROPN
admet-854	441	11	.	.	PROPN
admet-854	441	12	bunea	bunea	PROPN
admet-854	441	13	,	,	PUNCT
admet-854	441	14	a.	a.	PROPN
admet-854	441	15	gonzalez	gonzalez	PROPN
admet-854	441	16	-	-	PUNCT
admet-854	441	17	ramos	ramos	PROPN
admet-854	441	18	,	,	PUNCT
admet-854	441	19	t.	t.	PROPN
admet-854	441	20	ramos	ramos	PROPN
admet-854	441	21	-	-	PROPN
admet-854	441	22	moreno	moreno	PROPN
admet-854	441	23	,	,	PUNCT
admet-854	441	24	a.	a.	PROPN
admet-854	441	25	heiskanen	heiskanen	PROPN
admet-854	441	26	,	,	PUNCT
admet-854	441	27	m.	m.	NOUN
admet-854	441	28	kokaia	kokaia	PROPN
admet-854	441	29	,	,	PUNCT
admet-854	441	30	n.b	n.b	PROPN
admet-854	441	31	.	.	PROPN
admet-854	441	32	larsen	larsen	PROPN
admet-854	441	33	,	,	PUNCT
admet-854	441	34	a.	a.	PROPN
admet-854	441	35	martínez	martínez	PROPN
admet-854	441	36	-	-	PUNCT
admet-854	441	37	serrano	serrano	PROPN
admet-854	441	38	,	,	PUNCT
admet-854	441	39	s.s	s.s	PROPN
admet-854	441	40	.	.	PROPN
admet-854	441	41	keller	keller	PROPN
admet-854	441	42	,	,	PUNCT
admet-854	441	43	j.	j.	PROPN
admet-854	441	44	emnéus	emnéus	PROPN
admet-854	441	45	.	.	PUNCT
admet-854	442	1	leaky	leaky	ADJ
admet-854	442	2	optoelectrical	optoelectrical	ADJ
admet-854	442	3	fiber	fiber	NOUN
admet-854	442	4	for	for	ADP
admet-854	442	5	optogenetic	optogenetic	ADJ
admet-854	442	6	stimulation	stimulation	NOUN
admet-854	442	7	and	and	CCONJ
admet-854	442	8	electrochemical	electrochemical	ADJ
admet-854	442	9	detection	detection	NOUN
admet-854	442	10	of	of	ADP
admet-854	442	11	dopamine	dopamine	NOUN
admet-854	442	12	exocytosis	exocytosis	NOUN
admet-854	442	13	from	from	ADP
admet-854	442	14	human	human	ADJ
admet-854	442	15	dopaminergic	dopaminergic	ADJ
admet-854	442	16	neurons	neuron	NOUN
admet-854	442	17	.	.	PUNCT
admet-854	443	1	adv	adv	PROPN
admet-854	443	2	.	.	PUNCT
admet-854	444	1	sci	sci	PROPN
admet-854	444	2	.	.	PUNCT
admet-854	445	1	(	(	PUNCT
admet-854	445	2	weinh	weinh	NOUN
admet-854	445	3	)	)	PUNCT
admet-854	445	4	6	6	NUM
admet-854	445	5	(	(	PUNCT
admet-854	445	6	2019	2019	NUM
admet-854	445	7	)	)	PUNCT
admet-854	445	8	1902011	1902011	NUM
admet-854	445	9	.	.	PUNCT
admet-854	446	1	[	[	X
admet-854	446	2	14	14	NUM
admet-854	446	3	]	]	X
admet-854	446	4	n.g.m	n.g.m	PROPN
admet-854	446	5	.	.	PROPN
admet-854	446	6	oonk	oonk	PROPN
admet-854	446	7	,	,	PUNCT
admet-854	446	8	k.l.l	k.l.l	NOUN
admet-854	446	9	.	.	PROPN
admet-854	446	10	movig	movig	PROPN
admet-854	446	11	,	,	PUNCT
admet-854	446	12	e.m	e.m	PROPN
admet-854	446	13	.	.	PROPN
admet-854	446	14	munster	munster	PROPN
admet-854	446	15	,	,	PUNCT
admet-854	446	16	k.	k.	PROPN
admet-854	446	17	koehorst	koehorst	PROPN
admet-854	446	18	-	-	PUNCT
admet-854	446	19	ter	ter	NOUN
admet-854	446	20	huurne	huurne	ADJ
admet-854	446	21	,	,	PUNCT
admet-854	446	22	j.	j.	PROPN
admet-854	446	23	van	van	PROPN
admet-854	446	24	der	der	PROPN
admet-854	446	25	palen	palen	PROPN
admet-854	446	26	,	,	PUNCT
admet-854	446	27	l.d.a	l.d.a	PROPN
admet-854	446	28	.	.	PROPN
admet-854	446	29	dorresteijn	dorresteijn	PROPN
admet-854	446	30	.	.	PUNCT
admet-854	447	1	the	the	DET
admet-854	447	2	effect	effect	NOUN
admet-854	447	3	of	of	ADP
admet-854	447	4	a	a	DET
admet-854	447	5	structured	structure	VERB
admet-854	447	6	medication	medication	NOUN
admet-854	447	7	review	review	NOUN
admet-854	447	8	on	on	ADP
admet-854	447	9	quality	quality	NOUN
admet-854	447	10	of	of	ADP
admet-854	447	11	life	life	NOUN
admet-854	447	12	in	in	ADP
admet-854	447	13	parkinson	parkinson	NOUN
admet-854	447	14	's	's	PART
admet-854	447	15	disease	disease	NOUN
admet-854	447	16	:	:	PUNCT
admet-854	447	17	the	the	DET
admet-854	447	18	study	study	NOUN
admet-854	447	19	protocol	protocol	NOUN
admet-854	447	20	.	.	PUNCT
admet-854	448	1	contemp	contemp	NOUN
admet-854	448	2	.	.	PUNCT
admet-854	449	1	clin	clin	PROPN
admet-854	449	2	.	.	PUNCT
admet-854	450	1	trials	trial	NOUN
admet-854	450	2	commun	commun	VERB
admet-854	450	3	.	.	PUNCT
admet-854	450	4	13	13	NUM
admet-854	450	5	(	(	PUNCT
admet-854	450	6	2019	2019	NUM
admet-854	450	7	)	)	PUNCT
admet-854	450	8	100308	100308	NUM
admet-854	450	9	.	.	PUNCT
admet-854	451	1	[	[	X
admet-854	451	2	15	15	NUM
admet-854	451	3	]	]	X
admet-854	451	4	e.k	e.k	PROPN
admet-854	451	5	.	.	PROPN
admet-854	451	6	perry	perry	PROPN
admet-854	451	7	,	,	PUNCT
admet-854	451	8	m.	m.	PROPN
admet-854	451	9	curtis	curtis	PROPN
admet-854	451	10	,	,	PUNCT
admet-854	451	11	d.j	d.j	PROPN
admet-854	451	12	.	.	PROPN
admet-854	451	13	dick	dick	PROPN
admet-854	451	14	,	,	PUNCT
admet-854	451	15	j.m	j.m	PROPN
admet-854	451	16	.	.	PROPN
admet-854	451	17	candy	candy	PROPN
admet-854	451	18	,	,	PUNCT
admet-854	451	19	j.r	j.r	PROPN
admet-854	451	20	.	.	PROPN
admet-854	451	21	atack	atack	PROPN
admet-854	451	22	,	,	PUNCT
admet-854	451	23	c.a	c.a	PROPN
admet-854	451	24	.	.	PROPN
admet-854	451	25	bloxham	bloxham	PROPN
admet-854	451	26	,	,	PUNCT
admet-854	451	27	g.	g.	PROPN
admet-854	451	28	blessed	bless	VERB
admet-854	451	29	,	,	PUNCT
admet-854	451	30	a.	a.	PROPN
admet-854	451	31	fairbairn	fairbairn	PROPN
admet-854	451	32	,	,	PUNCT
admet-854	451	33	b.e	b.e	PROPN
admet-854	451	34	.	.	PROPN
admet-854	451	35	tomlinson	tomlinson	PROPN
admet-854	451	36	,	,	PUNCT
admet-854	451	37	r.h	r.h	PROPN
admet-854	451	38	.	.	PROPN
admet-854	451	39	perry	perry	PROPN
admet-854	451	40	.	.	PUNCT
admet-854	452	1	cholinergic	cholinergic	PROPN
admet-854	452	2	correlates	correlate	VERB
admet-854	452	3	of	of	ADP
admet-854	452	4	cognitive	cognitive	ADJ
admet-854	452	5	impairment	impairment	NOUN
admet-854	452	6	in	in	ADP
admet-854	452	7	parkinson	parkinson	NOUN
admet-854	452	8	's	's	PART
admet-854	452	9	disease	disease	NOUN
admet-854	452	10	:	:	PUNCT
admet-854	452	11	comparisons	comparison	NOUN
admet-854	452	12	with	with	ADP
admet-854	452	13	alzheimer	alzheimer	PROPN
admet-854	452	14	's	's	PART
admet-854	452	15	disease	disease	NOUN
admet-854	452	16	.	.	PUNCT
admet-854	453	1	j.	j.	PROPN
admet-854	453	2	neurol	neurol	PROPN
admet-854	453	3	.	.	PUNCT
admet-854	454	1	neurosurg	neurosurg	PROPN
admet-854	454	2	.	.	PUNCT
admet-854	455	1	psychiatry	psychiatry	NOUN
admet-854	455	2	48	48	NUM
admet-854	455	3	(	(	PUNCT
admet-854	455	4	1985	1985	NUM
admet-854	455	5	)	)	PUNCT
admet-854	455	6	413	413	NUM
admet-854	455	7	-	-	SYM
admet-854	455	8	421	421	NUM
admet-854	455	9	.	.	PUNCT
admet-854	456	1	[	[	X
admet-854	456	2	16	16	NUM
admet-854	456	3	]	]	X
admet-854	456	4	j.	j.	PROPN
admet-854	456	5	glowinski	glowinski	PROPN
admet-854	456	6	.	.	PUNCT
admet-854	457	1	recent	recent	ADJ
admet-854	457	2	finding	finding	NOUN
admet-854	457	3	on	on	ADP
admet-854	457	4	dopaminergic	dopaminergic	ADJ
admet-854	457	5	transmission	transmission	NOUN
admet-854	457	6	in	in	ADP
admet-854	457	7	the	the	DET
admet-854	457	8	basal	basal	ADJ
admet-854	457	9	ganglia	ganglia	NOUN
admet-854	457	10	.	.	PUNCT
admet-854	458	1	adv	adv	PROPN
admet-854	458	2	.	.	PUNCT
admet-854	459	1	neurol	neurol	PROPN
admet-854	459	2	.	.	PUNCT
admet-854	460	1	53	53	NUM
admet-854	460	2	(	(	PUNCT
admet-854	460	3	1990	1990	NUM
admet-854	460	4	)	)	PUNCT
admet-854	460	5	67	67	NUM
admet-854	460	6	-	-	SYM
admet-854	460	7	73	73	NUM
admet-854	460	8	.	.	PUNCT
admet-854	461	1	[	[	X
admet-854	461	2	17	17	NUM
admet-854	461	3	]	]	X
admet-854	461	4	j.p	j.p	PROPN
admet-854	461	5	.	.	PROPN
admet-854	461	6	mcevoy	mcevoy	PROPN
admet-854	461	7	.	.	PUNCT
admet-854	462	1	fda	fda	PROPN
admet-854	462	2	-	-	PUNCT
admet-854	462	3	approved	approve	VERB
admet-854	462	4	medications	medication	NOUN
admet-854	462	5	to	to	PART
admet-854	462	6	treat	treat	VERB
admet-854	462	7	tardive	tardive	ADJ
admet-854	462	8	dyskinesia	dyskinesia	NOUN
admet-854	462	9	.	.	PUNCT
admet-854	463	1	j.	j.	PROPN
admet-854	463	2	clin	clin	PROPN
admet-854	463	3	.	.	PUNCT
admet-854	464	1	psychiatry	psychiatry	NOUN
admet-854	464	2	81	81	NUM
admet-854	464	3	(	(	PUNCT
admet-854	464	4	2019	2019	NUM
admet-854	464	5	)	)	PUNCT
admet-854	464	6	nu18041br3c	nu18041br3c	ADJ
admet-854	464	7	.	.	PUNCT
admet-854	465	1	[	[	X
admet-854	465	2	18	18	NUM
admet-854	465	3	]	]	X
admet-854	465	4	c.	c.	PROPN
admet-854	465	5	zhuo	zhuo	PROPN
admet-854	465	6	,	,	PUNCT
admet-854	465	7	x.	x.	PROPN
admet-854	465	8	zhu	zhu	PROPN
admet-854	465	9	,	,	PUNCT
admet-854	465	10	r.	r.	PROPN
admet-854	465	11	jiang	jiang	PROPN
admet-854	465	12	,	,	PUNCT
admet-854	465	13	f.	f.	PROPN
admet-854	465	14	ji	ji	PROPN
admet-854	465	15	,	,	PUNCT
admet-854	465	16	z.	z.	PROPN
admet-854	465	17	su	su	PROPN
admet-854	465	18	,	,	PUNCT
admet-854	465	19	r.	r.	PROPN
admet-854	465	20	xue	xue	PROPN
admet-854	465	21	,	,	PUNCT
admet-854	465	22	y.	y.	PROPN
admet-854	465	23	zhou	zhou	PROPN
admet-854	465	24	.	.	PUNCT
admet-854	466	1	comparison	comparison	NOUN
admet-854	466	2	for	for	ADP
admet-854	466	3	efficacy	efficacy	NOUN
admet-854	466	4	and	and	CCONJ
admet-854	466	5	tolerability	tolerability	NOUN
admet-854	466	6	among	among	ADP
admet-854	466	7	ten	ten	NUM
admet-854	466	8	drugs	drug	NOUN
admet-854	466	9	for	for	ADP
admet-854	466	10	treatment	treatment	NOUN
admet-854	466	11	of	of	ADP
admet-854	466	12	parkinson	parkinson	NOUN
admet-854	466	13	's	's	PART
admet-854	466	14	disease	disease	NOUN
admet-854	466	15	:	:	PUNCT
admet-854	466	16	a	a	DET
admet-854	466	17	network	network	NOUN
admet-854	466	18	meta	meta	NOUN
admet-854	466	19	-	-	PUNCT
admet-854	466	20	analysis	analysis	NOUN
admet-854	466	21	.	.	PUNCT
admet-854	467	1	sci	sci	PROPN
admet-854	467	2	.	.	PROPN
admet-854	467	3	rep	rep	PROPN
admet-854	467	4	.	.	PROPN
admet-854	467	5	8	8	NUM
admet-854	467	6	(	(	PUNCT
admet-854	467	7	2017	2017	NUM
admet-854	467	8	)	)	PUNCT
admet-854	467	9	45865	45865	NUM
admet-854	467	10	.	.	PUNCT
admet-854	468	1	[	[	X
admet-854	468	2	19	19	NUM
admet-854	468	3	]	]	PUNCT
admet-854	468	4	k.	k.	NOUN
admet-854	468	5	nishiyama	nishiyama	PROPN
admet-854	468	6	,	,	PUNCT
admet-854	468	7	m.	m.	NOUN
admet-854	468	8	sugishita	sugishita	PROPN
admet-854	468	9	,	,	PUNCT
admet-854	468	10	h.	h.	PROPN
admet-854	468	11	kurisaki	kurisaki	PROPN
admet-854	468	12	,	,	PUNCT
admet-854	468	13	m.	m.	PROPN
admet-854	468	14	sakuta	sakuta	PROPN
admet-854	468	15	.	.	PUNCT
admet-854	469	1	reversible	reversible	ADJ
admet-854	469	2	memory	memory	NOUN
admet-854	469	3	disturbance	disturbance	NOUN
admet-854	469	4	and	and	CCONJ
admet-854	469	5	intelligence	intelligence	NOUN
admet-854	469	6	impairment	impairment	NOUN
admet-854	469	7	induced	induce	VERB
admet-854	469	8	by	by	ADP
admet-854	469	9	long	long	ADJ
admet-854	469	10	-	-	PUNCT
admet-854	469	11	term	term	NOUN
admet-854	469	12	anticholinergic	anticholinergic	ADJ
admet-854	469	13	therapy	therapy	NOUN
admet-854	469	14	.	.	PUNCT
admet-854	470	1	intern	intern	PROPN
admet-854	470	2	.	.	PUNCT
admet-854	470	3	med	med	PROPN
admet-854	470	4	.	.	PUNCT
admet-854	471	1	37	37	NUM
admet-854	471	2	(	(	PUNCT
admet-854	471	3	1998	1998	NUM
admet-854	471	4	)	)	PUNCT
admet-854	471	5	514	514	NUM
admet-854	471	6	-	-	SYM
admet-854	471	7	518	518	NUM
admet-854	471	8	.	.	PUNCT
admet-854	472	1	[	[	X
admet-854	472	2	20	20	NUM
admet-854	472	3	]	]	X
admet-854	472	4	y.	y.	PROPN
admet-854	472	5	baba	baba	PROPN
admet-854	472	6	,	,	PUNCT
admet-854	472	7	m.a	m.a	PROPN
admet-854	472	8	.	.	PROPN
admet-854	472	9	higuchi	higuchi	PROPN
admet-854	472	10	,	,	PUNCT
admet-854	472	11	h.	h.	PROPN
admet-854	472	12	abe	abe	PROPN
admet-854	472	13	,	,	PUNCT
admet-854	472	14	k.	k.	PROPN
admet-854	472	15	fukuyama	fukuyama	PROPN
admet-854	472	16	,	,	PUNCT
admet-854	472	17	r.	r.	PROPN
admet-854	472	18	onozawa	onozawa	PROPN
admet-854	472	19	,	,	PUNCT
admet-854	472	20	y.	y.	PROPN
admet-854	472	21	uehara	uehara	PROPN
admet-854	472	22	,	,	PUNCT
admet-854	472	23	t.	t.	PROPN
admet-854	472	24	inoue	inoue	PROPN
admet-854	472	25	,	,	PUNCT
admet-854	472	26	t.	t.	PROPN
admet-854	472	27	yamada	yamada	PROPN
admet-854	472	28	.	.	PUNCT
admet-854	473	1	anticholinergics	anticholinergic	NOUN
admet-854	473	2	for	for	ADP
admet-854	473	3	axial	axial	ADJ
admet-854	473	4	symptoms	symptom	NOUN
admet-854	473	5	in	in	ADP
admet-854	473	6	parkinson	parkinson	NOUN
admet-854	473	7	's	's	PART
admet-854	473	8	disease	disease	NOUN
admet-854	473	9	after	after	ADP
admet-854	473	10	subthalamic	subthalamic	ADJ
admet-854	473	11	stimulation	stimulation	NOUN
admet-854	473	12	.	.	PUNCT
admet-854	474	1	clin	clin	PROPN
admet-854	474	2	.	.	PUNCT
admet-854	475	1	neurol	neurol	PROPN
admet-854	475	2	.	.	PUNCT
admet-854	476	1	neurosurg	neurosurg	PROPN
admet-854	476	2	.	.	PUNCT
admet-854	477	1	114	114	NUM
admet-854	477	2	(	(	PUNCT
admet-854	477	3	2012	2012	NUM
admet-854	477	4	)	)	PUNCT
admet-854	477	5	1308	1308	NUM
admet-854	477	6	-	-	SYM
admet-854	477	7	1311	1311	NUM
admet-854	477	8	.	.	PUNCT
admet-854	478	1	[	[	X
admet-854	478	2	21	21	NUM
admet-854	478	3	]	]	PUNCT
admet-854	478	4	a.	a.	NOUN
admet-854	478	5	djamshidian	djamshidian	PROPN
admet-854	478	6	,	,	PUNCT
admet-854	478	7	w.	w.	PROPN
admet-854	478	8	poewe	poewe	PROPN
admet-854	478	9	.	.	PUNCT
admet-854	479	1	apomorphine	apomorphine	NOUN
admet-854	479	2	and	and	CCONJ
admet-854	479	3	levodopa	levodopa	NOUN
admet-854	479	4	in	in	ADP
admet-854	479	5	parkinson	parkinson	NOUN
admet-854	479	6	's	's	PART
admet-854	479	7	disease	disease	NOUN
admet-854	479	8	:	:	PUNCT
admet-854	479	9	two	two	NUM
admet-854	479	10	revolutionary	revolutionary	ADJ
admet-854	479	11	drugs	drug	NOUN
admet-854	479	12	from	from	ADP
admet-854	479	13	the	the	DET
admet-854	479	14	1950	1950	NUM
admet-854	479	15	's	's	PART
admet-854	479	16	.	.	PUNCT
admet-854	480	1	parkinsonism	parkinsonism	PROPN
admet-854	480	2	relat	relat	PROPN
admet-854	480	3	.	.	PUNCT
admet-854	481	1	disord	disord	NOUN
admet-854	481	2	.	.	PUNCT
admet-854	482	1	33	33	NUM
admet-854	482	2	suppl	suppl	ADJ
admet-854	482	3	1	1	NUM
admet-854	482	4	(	(	PUNCT
admet-854	482	5	2016	2016	NUM
admet-854	482	6	)	)	PUNCT
admet-854	482	7	s9	s9	NOUN
admet-854	482	8	-	-	PUNCT
admet-854	482	9	s12	s12	NOUN
admet-854	482	10	.	.	PUNCT
admet-854	483	1	[	[	X
admet-854	483	2	22	22	NUM
admet-854	483	3	]	]	PUNCT
admet-854	483	4	p.	p.	NOUN
admet-854	483	5	turcano	turcano	PROPN
admet-854	483	6	,	,	PUNCT
admet-854	483	7	m.m	m.m	PROPN
admet-854	483	8	.	.	PROPN
admet-854	483	9	mielke	mielke	PROPN
admet-854	483	10	,	,	PUNCT
admet-854	483	11	j.h	j.h	PROPN
admet-854	483	12	.	.	PROPN
admet-854	483	13	bower	bower	PROPN
admet-854	483	14	,	,	PUNCT
admet-854	483	15	j.e	j.e	PROPN
admet-854	483	16	.	.	PROPN
admet-854	483	17	parisi	parisi	PROPN
admet-854	483	18	,	,	PUNCT
admet-854	483	19	j.k	j.k	PROPN
admet-854	483	20	.	.	PROPN
admet-854	483	21	cutsforth	cutsforth	PROPN
admet-854	483	22	-	-	PUNCT
admet-854	483	23	gregory	gregory	PROPN
admet-854	483	24	,	,	PUNCT
admet-854	483	25	j.e	j.e	PROPN
admet-854	483	26	.	.	PROPN
admet-854	483	27	ahlskog	ahlskog	PROPN
admet-854	483	28	,	,	PUNCT
admet-854	483	29	r.	r.	PROPN
admet-854	483	30	savica	savica	PROPN
admet-854	483	31	.	.	PUNCT
admet-854	484	1	levodopa	levodopa	NOUN
admet-854	484	2	-	-	PUNCT
admet-854	484	3	induced	induce	VERB
admet-854	484	4	dyskinesia	dyskinesia	NOUN
admet-854	484	5	in	in	ADP
admet-854	484	6	parkinson	parkinson	NOUN
admet-854	484	7	disease	disease	NOUN
admet-854	484	8	:	:	PUNCT
admet-854	484	9	a	a	DET
admet-854	484	10	population	population	NOUN
admet-854	484	11	-	-	PUNCT
admet-854	484	12	based	base	VERB
admet-854	484	13	cohort	cohort	NOUN
admet-854	484	14	study	study	NOUN
admet-854	484	15	.	.	PUNCT
admet-854	485	1	neurology	neurology	NOUN
admet-854	485	2	91	91	NUM
admet-854	485	3	(	(	PUNCT
admet-854	485	4	2018	2018	NUM
admet-854	485	5	)	)	PUNCT
admet-854	485	6	e2238	e2238	PROPN
admet-854	485	7	-	-	PUNCT
admet-854	485	8	e2243	e2243	NOUN
admet-854	485	9	.	.	PUNCT
admet-854	486	1	[	[	X
admet-854	486	2	23	23	NUM
admet-854	486	3	]	]	PUNCT
admet-854	486	4	k.	k.	PROPN
admet-854	486	5	dashtipour	dashtipour	PROPN
admet-854	486	6	,	,	PUNCT
admet-854	486	7	a.r	a.r	PROPN
admet-854	486	8	.	.	PROPN
admet-854	486	9	tafreshi	tafreshi	PROPN
admet-854	486	10	,	,	PUNCT
admet-854	486	11	r.	r.	PROPN
admet-854	486	12	pahwa	pahwa	PROPN
admet-854	486	13	,	,	PUNCT
admet-854	486	14	k.e	k.e	PROPN
admet-854	486	15	.	.	PUNCT
admet-854	486	16	lyons	lyons	PROPN
admet-854	486	17	.	.	PUNCT
admet-854	487	1	extended	extend	VERB
admet-854	487	2	-	-	PUNCT
admet-854	487	3	release	release	NOUN
admet-854	487	4	amantadine	amantadine	NOUN
admet-854	487	5	for	for	ADP
admet-854	487	6	levodopainduced	levodopainduce	VERB
admet-854	487	7	dyskinesia	dyskinesia	NOUN
admet-854	487	8	.	.	PUNCT
admet-854	488	1	expert	expert	NOUN
admet-854	488	2	rev	rev	PROPN
admet-854	488	3	.	.	PUNCT
admet-854	488	4	neurother	neurother	PROPN
admet-854	488	5	.	.	PUNCT
admet-854	489	1	19	19	NUM
admet-854	489	2	(	(	PUNCT
admet-854	489	3	2019	2019	NUM
admet-854	489	4	)	)	PUNCT
admet-854	489	5	293	293	NUM
admet-854	489	6	-	-	SYM
admet-854	489	7	299	299	NUM
admet-854	489	8	.	.	PUNCT
admet-854	490	1	[	[	X
admet-854	490	2	24	24	NUM
admet-854	490	3	]	]	PUNCT
admet-854	490	4	p.	p.	PROPN
admet-854	490	5	garcia	garcia	PROPN
admet-854	490	6	-	-	PUNCT
admet-854	490	7	esparcia	esparcia	PROPN
admet-854	490	8	,	,	PUNCT
admet-854	490	9	k.	k.	PROPN
admet-854	490	10	hernández	hernández	PROPN
admet-854	490	11	-	-	PUNCT
admet-854	490	12	ortega	ortega	PROPN
admet-854	490	13	,	,	PUNCT
admet-854	490	14	b.	b.	PROPN
admet-854	490	15	ansoleaga	ansoleaga	PROPN
admet-854	490	16	,	,	PUNCT
admet-854	490	17	m.	m.	NOUN
admet-854	490	18	carmona	carmona	PROPN
admet-854	490	19	,	,	PUNCT
admet-854	490	20	i.	i.	PROPN
admet-854	490	21	ferrer	ferrer	PROPN
admet-854	490	22	.	.	PUNCT
admet-854	491	1	purine	purine	NOUN
admet-854	491	2	metabolism	metabolism	NOUN
admet-854	491	3	gene	gene	NOUN
admet-854	491	4	deregulation	deregulation	NOUN
admet-854	491	5	in	in	ADP
admet-854	491	6	parkinson	parkinson	NOUN
admet-854	491	7	's	's	PART
admet-854	491	8	disease	disease	NOUN
admet-854	491	9	.	.	PUNCT
admet-854	492	1	neuropathol	neuropathol	NOUN
admet-854	492	2	.	.	PUNCT
admet-854	493	1	appl	appl	PROPN
admet-854	493	2	.	.	PUNCT
admet-854	494	1	neurobiol	neurobiol	PROPN
admet-854	494	2	.	.	PUNCT
admet-854	495	1	41	41	NUM
admet-854	495	2	(	(	PUNCT
admet-854	495	3	2015	2015	NUM
admet-854	495	4	)	)	PUNCT
admet-854	495	5	926	926	NUM
admet-854	495	6	-	-	SYM
admet-854	495	7	940	940	NUM
admet-854	495	8	.	.	PUNCT
admet-854	496	1	[	[	X
admet-854	496	2	25	25	NUM
admet-854	496	3	]	]	X
admet-854	496	4	t.m	t.m	PROPN
admet-854	496	5	.	.	PROPN
admet-854	496	6	seccia	seccia	PROPN
admet-854	496	7	,	,	PUNCT
admet-854	496	8	a.	a.	NOUN
admet-854	496	9	atlante	atlante	PROPN
admet-854	496	10	,	,	PUNCT
admet-854	496	11	v.	v.	ADP
admet-854	496	12	vulpis	vulpis	NOUN
admet-854	496	13	,	,	PUNCT
admet-854	496	14	e.	e.	PROPN
admet-854	496	15	marra	marra	PROPN
admet-854	496	16	,	,	PUNCT
admet-854	496	17	s.	s.	PROPN
admet-854	496	18	passarella	passarella	PROPN
admet-854	496	19	,	,	PUNCT
admet-854	496	20	a.	a.	NOUN
admet-854	496	21	pirrelli	pirrelli	NOUN
admet-854	496	22	.	.	PUNCT
admet-854	497	1	mitochondrial	mitochondrial	ADJ
admet-854	497	2	energy	energy	NOUN
admet-854	497	3	metabolism	metabolism	NOUN
admet-854	497	4	in	in	ADP
admet-854	497	5	the	the	DET
admet-854	497	6	left	left	ADJ
admet-854	497	7	ventricular	ventricular	ADJ
admet-854	497	8	tissue	tissue	NOUN
admet-854	497	9	of	of	ADP
admet-854	497	10	spontaneously	spontaneously	ADV
admet-854	497	11	hypertensive	hypertensive	ADJ
admet-854	497	12	rats	rat	NOUN
admet-854	497	13	:	:	PUNCT
admet-854	497	14	abnormalities	abnormality	NOUN
admet-854	497	15	in	in	ADP
admet-854	497	16	both	both	CCONJ
admet-854	497	17	adeninenucleotide	adeninenucleotide	ADJ
admet-854	497	18	and	and	CCONJ
admet-854	497	19	phosphate	phosphate	ADJ
admet-854	497	20	translocators	translocator	NOUN
admet-854	497	21	and	and	CCONJ
admet-854	497	22	enzyme	enzyme	VERB
admet-854	497	23	adenylate	adenylate	ADJ
admet-854	497	24	-	-	PUNCT
admet-854	497	25	kinase	kinase	NOUN
admet-854	497	26	and	and	CCONJ
admet-854	497	27	creatinephosphokinase	creatinephosphokinase	NOUN
admet-854	497	28	activities	activity	NOUN
admet-854	497	29	.	.	PUNCT
admet-854	498	1	clin	clin	PROPN
admet-854	498	2	.	.	PUNCT
admet-854	499	1	exp	exp	PROPN
admet-854	499	2	.	.	PUNCT
admet-854	499	3	hypertens	hypertens	PROPN
admet-854	499	4	.	.	PUNCT
admet-854	500	1	20	20	NUM
admet-854	500	2	(	(	PUNCT
admet-854	500	3	1998	1998	NUM
admet-854	500	4	)	)	PUNCT
admet-854	500	5	345	345	NUM
admet-854	500	6	-	-	SYM
admet-854	500	7	358	358	NUM
admet-854	500	8	.	.	PUNCT
admet-854	501	1	admet	admet	PROPN
admet-854	501	2	&	&	CCONJ
admet-854	501	3	dmpk	dmpk	PROPN
admet-854	501	4	8(2	8(2	NUM
admet-854	501	5	)	)	PUNCT
admet-854	501	6	(	(	PUNCT
admet-854	501	7	2020	2020	NUM
admet-854	501	8	)	)	PUNCT
admet-854	501	9	149	149	NUM
admet-854	501	10	-	-	SYM
admet-854	501	11	175	175	NUM
admet-854	501	12	amantadine	amantadine	NOUN
admet-854	501	13	binding	bind	VERB
admet-854	501	14	to	to	ADP
admet-854	501	15	the	the	DET
admet-854	501	16	enzymes	enzyme	NOUN
admet-854	501	17	regulated	regulate	VERB
admet-854	501	18	in	in	ADP
admet-854	501	19	parkinson	parkinson	NOUN
admet-854	501	20	’s	’s	PART
admet-854	501	21	disease	disease	NOUN
admet-854	501	22	doi	doi	NOUN
admet-854	501	23	:	:	PUNCT
admet-854	501	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	501	25	171	171	NUM
admet-854	502	1	[	[	X
admet-854	502	2	26	26	NUM
admet-854	502	3	]	]	X
admet-854	502	4	z.h	z.h	PROPN
admet-854	502	5	.	.	PROPN
admet-854	502	6	wang	wang	PROPN
admet-854	502	7	,	,	PUNCT
admet-854	502	8	x.l	x.l	PROPN
admet-854	502	9	.	.	PROPN
admet-854	502	10	cai	cai	PROPN
admet-854	502	11	,	,	PUNCT
admet-854	502	12	l.	l.	PROPN
admet-854	502	13	wu	wu	PROPN
admet-854	502	14	,	,	PUNCT
admet-854	502	15	z.	z.	PROPN
admet-854	502	16	yu	yu	PROPN
admet-854	502	17	,	,	PUNCT
admet-854	503	1	j.l	j.l	PROPN
admet-854	503	2	.	.	PROPN
admet-854	503	3	liu	liu	PROPN
admet-854	503	4	,	,	PUNCT
admet-854	503	5	z.n	z.n	PROPN
admet-854	503	6	.	.	PROPN
admet-854	503	7	zhou	zhou	PROPN
admet-854	503	8	,	,	PUNCT
admet-854	503	9	j.	j.	PROPN
admet-854	503	10	liu	liu	PROPN
admet-854	503	11	,	,	PUNCT
admet-854	503	12	h.t	h.t	PROPN
admet-854	503	13	.	.	PROPN
admet-854	503	14	yang	yang	PROPN
admet-854	503	15	.	.	PUNCT
admet-854	504	1	mitochondrial	mitochondrial	ADJ
admet-854	504	2	energy	energy	NOUN
admet-854	504	3	metabolism	metabolism	NOUN
admet-854	504	4	plays	play	VERB
admet-854	504	5	a	a	DET
admet-854	504	6	critical	critical	ADJ
admet-854	504	7	role	role	NOUN
admet-854	504	8	in	in	ADP
admet-854	504	9	the	the	DET
admet-854	504	10	cardioprotection	cardioprotection	NOUN
admet-854	504	11	afforded	afford	VERB
admet-854	504	12	by	by	ADP
admet-854	504	13	intermittent	intermittent	ADJ
admet-854	504	14	hypobaric	hypobaric	ADJ
admet-854	504	15	hypoxia	hypoxia	NOUN
admet-854	504	16	.	.	PUNCT
admet-854	505	1	exp	exp	NOUN
admet-854	505	2	.	.	PUNCT
admet-854	505	3	physiol	physiol	PROPN
admet-854	505	4	.	.	PUNCT
admet-854	506	1	97	97	NUM
admet-854	506	2	(	(	PUNCT
admet-854	506	3	2012	2012	NUM
admet-854	506	4	)	)	PUNCT
admet-854	506	5	1105	1105	NUM
admet-854	506	6	-	-	SYM
admet-854	506	7	1118	1118	NUM
admet-854	506	8	.	.	PUNCT
admet-854	507	1	[	[	X
admet-854	507	2	27	27	NUM
admet-854	507	3	]	]	X
admet-854	507	4	y.	y.	PROPN
admet-854	507	5	ge	ge	PROPN
admet-854	507	6	,	,	PUNCT
admet-854	507	7	m.p	m.p	PROPN
admet-854	507	8	.	.	PROPN
admet-854	507	9	molloy	molloy	PROPN
admet-854	507	10	,	,	PUNCT
admet-854	507	11	j.s	j.s	PROPN
admet-854	507	12	.	.	PUNCT
admet-854	508	1	chamberlain	chamberlain	PROPN
admet-854	508	2	,	,	PUNCT
admet-854	508	3	p.c	p.c	PROPN
admet-854	508	4	.	.	PROPN
admet-854	508	5	andrews	andrews	PROPN
admet-854	508	6	.	.	PUNCT
admet-854	509	1	proteomic	proteomic	ADJ
admet-854	509	2	analysis	analysis	NOUN
admet-854	509	3	of	of	ADP
admet-854	509	4	mdx	mdx	NOUN
admet-854	509	5	skeletal	skeletal	ADJ
admet-854	509	6	muscle	muscle	NOUN
admet-854	509	7	:	:	PUNCT
admet-854	509	8	great	great	ADJ
admet-854	509	9	reduction	reduction	NOUN
admet-854	509	10	of	of	ADP
admet-854	509	11	adenylate	adenylate	ADJ
admet-854	509	12	kinase	kinase	NOUN
admet-854	509	13	1	1	NUM
admet-854	509	14	expression	expression	NOUN
admet-854	509	15	and	and	CCONJ
admet-854	509	16	enzymatic	enzymatic	ADJ
admet-854	509	17	activity	activity	NOUN
admet-854	509	18	.	.	PUNCT
admet-854	510	1	proteomics	proteomic	NOUN
admet-854	510	2	3	3	NUM
admet-854	510	3	(	(	PUNCT
admet-854	510	4	2003	2003	NUM
admet-854	510	5	)	)	PUNCT
admet-854	510	6	1895	1895	NUM
admet-854	510	7	-	-	SYM
admet-854	510	8	1903	1903	NUM
admet-854	510	9	.	.	PUNCT
admet-854	511	1	[	[	X
admet-854	511	2	28	28	NUM
admet-854	511	3	]	]	X
admet-854	511	4	t.	t.	NOUN
admet-854	511	5	gamberi	gamberi	NOUN
admet-854	511	6	,	,	PUNCT
admet-854	511	7	t.	t.	PROPN
admet-854	511	8	fiaschi	fiaschi	PROPN
admet-854	511	9	,	,	PUNCT
admet-854	511	10	e.	e.	PROPN
admet-854	511	11	valocchia	valocchia	PROPN
admet-854	511	12	,	,	PUNCT
admet-854	511	13	a.	a.	NOUN
admet-854	511	14	modesti	modesti	PROPN
admet-854	511	15	,	,	PUNCT
admet-854	511	16	p.	p.	NOUN
admet-854	511	17	mantuano	mantuano	NOUN
admet-854	511	18	,	,	PUNCT
admet-854	511	19	j.f	j.f	PROPN
admet-854	511	20	.	.	PROPN
admet-854	511	21	rolland	rolland	PROPN
admet-854	511	22	,	,	PUNCT
admet-854	511	23	f.	f.	PROPN
admet-854	511	24	sanarica	sanarica	PROPN
admet-854	511	25	,	,	PUNCT
admet-854	511	26	a.	a.	PROPN
admet-854	511	27	de	de	PROPN
admet-854	511	28	luca	luca	PROPN
admet-854	511	29	,	,	PUNCT
admet-854	511	30	f.	f.	PROPN
admet-854	511	31	magherini	magherini	PROPN
admet-854	511	32	.	.	PUNCT
admet-854	512	1	proteome	proteome	ADJ
admet-854	512	2	analysis	analysis	NOUN
admet-854	512	3	in	in	ADP
admet-854	512	4	dystrophic	dystrophic	ADJ
admet-854	512	5	mdx	mdx	NOUN
admet-854	512	6	mouse	mouse	PROPN
admet-854	512	7	muscle	muscle	NOUN
admet-854	512	8	reveals	reveal	VERB
admet-854	512	9	a	a	DET
admet-854	512	10	drastic	drastic	ADJ
admet-854	512	11	alteration	alteration	NOUN
admet-854	512	12	of	of	ADP
admet-854	512	13	key	key	ADJ
admet-854	512	14	metabolic	metabolic	NOUN
admet-854	512	15	and	and	CCONJ
admet-854	512	16	contractile	contractile	NOUN
admet-854	512	17	proteins	protein	NOUN
admet-854	512	18	after	after	ADP
admet-854	512	19	chronic	chronic	ADJ
admet-854	512	20	exercise	exercise	NOUN
admet-854	512	21	and	and	CCONJ
admet-854	512	22	the	the	DET
admet-854	512	23	potential	potential	ADJ
admet-854	512	24	modulation	modulation	NOUN
admet-854	512	25	by	by	ADP
admet-854	512	26	antioxidant	antioxidant	ADJ
admet-854	512	27	compounds	compound	NOUN
admet-854	512	28	.	.	PUNCT
admet-854	513	1	j.	j.	PROPN
admet-854	513	2	proteomics	proteomics	PROPN
admet-854	513	3	170	170	NUM
admet-854	513	4	(	(	PUNCT
admet-854	513	5	2018	2018	NUM
admet-854	513	6	)	)	PUNCT
admet-854	513	7	43	43	NUM
admet-854	513	8	-	-	SYM
admet-854	513	9	58	58	NUM
admet-854	513	10	.	.	PUNCT
admet-854	514	1	[	[	X
admet-854	514	2	29	29	NUM
admet-854	514	3	]	]	PUNCT
admet-854	514	4	t.	t.	PROPN
admet-854	514	5	fröhlich	fröhlich	PROPN
admet-854	514	6	,	,	PUNCT
admet-854	514	7	b.	b.	PROPN
admet-854	514	8	reitter	reitter	PROPN
admet-854	514	9	,	,	PUNCT
admet-854	514	10	d.	d.	PROPN
admet-854	514	11	scheffner	scheffner	PROPN
admet-854	514	12	,	,	PUNCT
admet-854	514	13	r.h	r.h	PROPN
admet-854	514	14	.	.	PROPN
admet-854	514	15	schirmer	schirmer	PROPN
admet-854	514	16	,	,	PUNCT
admet-854	514	17	r.	r.	PROPN
admet-854	514	18	untucht	untucht	PROPN
admet-854	514	19	-	-	PUNCT
admet-854	514	20	grau	grau	NOUN
admet-854	514	21	.	.	PUNCT
admet-854	515	1	muscle	muscle	PROPN
admet-854	515	2	adenylate	adenylate	ADJ
admet-854	515	3	kinase	kinase	NOUN
admet-854	515	4	in	in	ADP
admet-854	515	5	duchenne	duchenne	NOUN
admet-854	515	6	muscular	muscular	ADJ
admet-854	515	7	dystrophy	dystrophy	NOUN
admet-854	515	8	.	.	PUNCT
admet-854	516	1	biochim	biochim	NOUN
admet-854	516	2	.	.	PUNCT
admet-854	517	1	biophys	biophy	NOUN
admet-854	517	2	.	.	PUNCT
admet-854	518	1	acta	acta	PROPN
admet-854	518	2	883	883	NUM
admet-854	518	3	(	(	PUNCT
admet-854	518	4	1986	1986	NUM
admet-854	518	5	)	)	PUNCT
admet-854	518	6	598	598	NUM
admet-854	518	7	-	-	SYM
admet-854	518	8	603	603	NUM
admet-854	518	9	.	.	PUNCT
admet-854	519	1	[	[	X
admet-854	519	2	30	30	NUM
admet-854	519	3	]	]	X
admet-854	519	4	m.	m.	PROPN
admet-854	519	5	hamada	hamada	PROPN
admet-854	519	6	,	,	PUNCT
admet-854	519	7	h.	h.	PROPN
admet-854	519	8	okuda	okuda	PROPN
admet-854	519	9	,	,	PUNCT
admet-854	519	10	k.	k.	PROPN
admet-854	519	11	oka	oka	PROPN
admet-854	519	12	,	,	PUNCT
admet-854	519	13	t.	t.	PROPN
admet-854	519	14	watanabe	watanabe	PROPN
admet-854	519	15	,	,	PUNCT
admet-854	519	16	k.	k.	PROPN
admet-854	519	17	ueda	ueda	PROPN
admet-854	519	18	,	,	PUNCT
admet-854	519	19	m.	m.	PROPN
admet-854	519	20	nojima	nojima	PROPN
admet-854	519	21	,	,	PUNCT
admet-854	519	22	s.a	s.a	PROPN
admet-854	519	23	.	.	PROPN
admet-854	519	24	kuby	kuby	PROPN
admet-854	519	25	,	,	PUNCT
admet-854	519	26	m.	m.	NOUN
admet-854	519	27	manship	manship	PROPN
admet-854	519	28	,	,	PUNCT
admet-854	519	29	f.h	f.h	PROPN
admet-854	519	30	.	.	PROPN
admet-854	519	31	tyler	tyler	PROPN
admet-854	519	32	,	,	PUNCT
admet-854	519	33	f.a	f.a	PROPN
admet-854	519	34	.	.	PROPN
admet-854	519	35	ziter	ziter	NOUN
admet-854	519	36	.	.	PUNCT
admet-854	520	1	an	an	DET
admet-854	520	2	aberrant	aberrant	ADJ
admet-854	520	3	adenylate	adenylate	ADJ
admet-854	520	4	kinase	kinase	NOUN
admet-854	520	5	isoenzyme	isoenzyme	NOUN
admet-854	520	6	from	from	ADP
admet-854	520	7	the	the	DET
admet-854	520	8	serum	serum	NOUN
admet-854	520	9	of	of	ADP
admet-854	520	10	patients	patient	NOUN
admet-854	520	11	with	with	ADP
admet-854	520	12	duchenne	duchenne	ADJ
admet-854	520	13	muscular	muscular	ADJ
admet-854	520	14	dystrophy	dystrophy	NOUN
admet-854	520	15	.	.	PUNCT
admet-854	521	1	biochim	biochim	NOUN
admet-854	521	2	.	.	PUNCT
admet-854	522	1	biophys	biophy	NOUN
admet-854	522	2	.	.	PUNCT
admet-854	523	1	acta	acta	PROPN
admet-854	523	2	660	660	NUM
admet-854	523	3	(	(	PUNCT
admet-854	523	4	1981	1981	NUM
admet-854	523	5	)	)	PUNCT
admet-854	523	6	227	227	NUM
admet-854	523	7	-	-	SYM
admet-854	523	8	237	237	NUM
admet-854	523	9	.	.	PUNCT
admet-854	524	1	[	[	X
admet-854	524	2	31	31	NUM
admet-854	524	3	]	]	PUNCT
admet-854	524	4	r.	r.	PROPN
admet-854	524	5	spector	spector	PROPN
admet-854	524	6	.	.	PUNCT
admet-854	525	1	transport	transport	NOUN
admet-854	525	2	of	of	ADP
admet-854	525	3	amantadine	amantadine	NOUN
admet-854	525	4	and	and	CCONJ
admet-854	525	5	rimantadine	rimantadine	NOUN
admet-854	525	6	through	through	ADP
admet-854	525	7	the	the	DET
admet-854	525	8	blood	blood	NOUN
admet-854	525	9	-	-	PUNCT
admet-854	525	10	brain	brain	NOUN
admet-854	525	11	barrier	barrier	NOUN
admet-854	525	12	.	.	PUNCT
admet-854	526	1	j.	j.	PROPN
admet-854	526	2	pharmacol	pharmacol	PROPN
admet-854	526	3	.	.	PUNCT
admet-854	527	1	exp	exp	PROPN
admet-854	527	2	.	.	PUNCT
admet-854	528	1	ther	ther	PROPN
admet-854	528	2	.	.	PUNCT
admet-854	529	1	244	244	NUM
admet-854	529	2	(	(	PUNCT
admet-854	529	3	1988	1988	NUM
admet-854	529	4	)	)	PUNCT
admet-854	529	5	516	516	NUM
admet-854	529	6	-	-	SYM
admet-854	529	7	519	519	NUM
admet-854	529	8	.	.	PUNCT
admet-854	530	1	[	[	X
admet-854	530	2	32	32	NUM
admet-854	530	3	]	]	PUNCT
admet-854	530	4	s.	s.	PROPN
admet-854	530	5	moon	moon	PROPN
admet-854	530	6	,	,	PUNCT
admet-854	530	7	j.	j.	PROPN
admet-854	530	8	kim	kim	PROPN
admet-854	530	9	,	,	PUNCT
admet-854	530	10	e.	e.	PROPN
admet-854	530	11	bae	bae	PROPN
admet-854	530	12	.	.	PUNCT
admet-854	531	1	structural	structural	ADJ
admet-854	531	2	analyses	analysis	NOUN
admet-854	531	3	of	of	ADP
admet-854	531	4	adenylate	adenylate	ADJ
admet-854	531	5	kinases	kinase	NOUN
admet-854	531	6	from	from	ADP
admet-854	531	7	antarctic	antarctic	ADJ
admet-854	531	8	and	and	CCONJ
admet-854	531	9	tropical	tropical	ADJ
admet-854	531	10	fishes	fish	NOUN
admet-854	531	11	for	for	ADP
admet-854	531	12	understanding	understand	VERB
admet-854	531	13	cold	cold	ADJ
admet-854	531	14	adaptation	adaptation	NOUN
admet-854	531	15	of	of	ADP
admet-854	531	16	enzymes	enzyme	NOUN
admet-854	531	17	.	.	PUNCT
admet-854	532	1	sci	sci	PROPN
admet-854	532	2	.	.	PROPN
admet-854	532	3	rep	rep	PROPN
admet-854	532	4	.	.	PROPN
admet-854	532	5	7	7	NUM
admet-854	532	6	(	(	PUNCT
admet-854	532	7	2017	2017	NUM
admet-854	532	8	)	)	PUNCT
admet-854	532	9	16027	16027	NUM
admet-854	532	10	.	.	PUNCT
admet-854	533	1	[	[	X
admet-854	533	2	33	33	NUM
admet-854	533	3	]	]	X
admet-854	533	4	t.p	t.p	PROPN
admet-854	533	5	.	.	PROPN
admet-854	533	6	schrank	schrank	PROPN
admet-854	533	7	,	,	PUNCT
admet-854	533	8	d.w	d.w	PROPN
admet-854	533	9	.	.	PROPN
admet-854	533	10	bolen	bolen	PROPN
admet-854	533	11	,	,	PUNCT
admet-854	533	12	v.j	v.j	PROPN
admet-854	533	13	.	.	PROPN
admet-854	533	14	hilser	hilser	NOUN
admet-854	533	15	.	.	PUNCT
admet-854	534	1	rational	rational	ADJ
admet-854	534	2	modulation	modulation	NOUN
admet-854	534	3	of	of	ADP
admet-854	534	4	conformational	conformational	ADJ
admet-854	534	5	fluctuations	fluctuation	NOUN
admet-854	534	6	in	in	ADP
admet-854	534	7	adenylate	adenylate	ADJ
admet-854	534	8	kinase	kinase	NOUN
admet-854	534	9	reveals	reveal	VERB
admet-854	534	10	a	a	DET
admet-854	534	11	local	local	ADJ
admet-854	534	12	unfolding	unfold	VERB
admet-854	534	13	mechanism	mechanism	NOUN
admet-854	534	14	for	for	ADP
admet-854	534	15	allostery	allostery	NOUN
admet-854	534	16	and	and	CCONJ
admet-854	534	17	functional	functional	ADJ
admet-854	534	18	adaptation	adaptation	NOUN
admet-854	534	19	in	in	ADP
admet-854	534	20	proteins	protein	NOUN
admet-854	534	21	.	.	PUNCT
admet-854	535	1	proc	proc	NOUN
admet-854	535	2	.	.	PUNCT
admet-854	536	1	natl	natl	PROPN
admet-854	536	2	.	.	PUNCT
admet-854	537	1	acad	acad	PROPN
admet-854	537	2	.	.	PUNCT
admet-854	538	1	sci	sci	PROPN
admet-854	538	2	.	.	PUNCT
admet-854	538	3	u.s.a	u.s.a	PROPN
admet-854	538	4	.	.	PROPN
admet-854	538	5	106	106	NUM
admet-854	538	6	(	(	PUNCT
admet-854	538	7	2009	2009	NUM
admet-854	538	8	)	)	PUNCT
admet-854	538	9	16984	16984	NUM
admet-854	538	10	-	-	SYM
admet-854	538	11	16989	16989	NUM
admet-854	538	12	.	.	PUNCT
admet-854	539	1	[	[	X
admet-854	539	2	34	34	NUM
admet-854	539	3	]	]	X
admet-854	539	4	m.b	m.b	PROPN
admet-854	539	5	.	.	PROPN
admet-854	539	6	berry	berry	PROPN
admet-854	539	7	,	,	PUNCT
admet-854	539	8	g.n	g.n	PROPN
admet-854	539	9	.	.	PROPN
admet-854	539	10	phillips	phillips	PROPN
admet-854	539	11	.	.	PUNCT
admet-854	540	1	crystal	crystal	NOUN
admet-854	540	2	structures	structure	NOUN
admet-854	540	3	of	of	ADP
admet-854	540	4	bacillus	bacillus	NOUN
admet-854	540	5	stearothermophilus	stearothermophilus	NOUN
admet-854	540	6	adenylate	adenylate	ADJ
admet-854	540	7	kinase	kinase	NOUN
admet-854	540	8	with	with	ADP
admet-854	540	9	bound	bind	VERB
admet-854	540	10	ap5a	ap5a	PROPN
admet-854	540	11	,	,	PUNCT
admet-854	540	12	mg2	mg2	PROPN
admet-854	540	13	+	+	PROPN
admet-854	540	14	ap5a	ap5a	PROPN
admet-854	540	15	,	,	PUNCT
admet-854	540	16	and	and	CCONJ
admet-854	540	17	mn2	mn2	VERB
admet-854	540	18	+	+	CCONJ
admet-854	540	19	ap5a	ap5a	NOUN
admet-854	540	20	reveal	reveal	VERB
admet-854	540	21	an	an	DET
admet-854	540	22	intermediate	intermediate	ADJ
admet-854	540	23	lid	lid	NOUN
admet-854	540	24	position	position	NOUN
admet-854	540	25	and	and	CCONJ
admet-854	540	26	six	six	NUM
admet-854	540	27	coordinate	coordinate	ADJ
admet-854	540	28	octahedral	octahedral	ADJ
admet-854	540	29	geometry	geometry	NOUN
admet-854	540	30	for	for	ADP
admet-854	540	31	bound	bind	VERB
admet-854	540	32	mg2	mg2	PROPN
admet-854	540	33	+	+	PROPN
admet-854	540	34	and	and	CCONJ
admet-854	540	35	mn2	mn2	VERB
admet-854	540	36	+	+	NOUN
admet-854	540	37	.	.	PUNCT
admet-854	540	38	proteins	protein	NOUN
admet-854	540	39	32	32	NUM
admet-854	540	40	(	(	PUNCT
admet-854	540	41	1998	1998	NUM
admet-854	540	42	)	)	PUNCT
admet-854	540	43	276	276	NUM
admet-854	540	44	-	-	SYM
admet-854	540	45	288	288	NUM
admet-854	541	1	[	[	SYM
admet-854	541	2	35	35	NUM
admet-854	541	3	]	]	PUNCT
admet-854	541	4	m.	m.	NOUN
admet-854	541	5	silva	silva	PROPN
admet-854	541	6	,	,	PUNCT
admet-854	541	7	c.h	c.h	PROPN
admet-854	541	8	.	.	PROPN
admet-854	541	9	silva	silva	PROPN
admet-854	541	10	,	,	PUNCT
admet-854	541	11	j.	j.	PROPN
admet-854	541	12	iulek	iulek	PROPN
admet-854	541	13	,	,	PUNCT
admet-854	541	14	o.h	o.h	PROPN
admet-854	541	15	.	.	PROPN
admet-854	541	16	thiemann	thiemann	PROPN
admet-854	541	17	.	.	PUNCT
admet-854	542	1	three	three	NUM
admet-854	542	2	-	-	PUNCT
admet-854	542	3	dimensional	dimensional	ADJ
admet-854	542	4	structure	structure	NOUN
admet-854	542	5	of	of	ADP
admet-854	542	6	human	human	ADJ
admet-854	542	7	adenine	adenine	NOUN
admet-854	542	8	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	542	9	and	and	CCONJ
admet-854	542	10	its	its	PRON
admet-854	542	11	relation	relation	NOUN
admet-854	542	12	to	to	ADP
admet-854	542	13	dha	dha	PROPN
admet-854	542	14	-	-	PUNCT
admet-854	542	15	urolithiasis	urolithiasis	NOUN
admet-854	542	16	.	.	PUNCT
admet-854	543	1	biochemistry	biochemistry	NOUN
admet-854	543	2	43	43	NUM
admet-854	543	3	(	(	PUNCT
admet-854	543	4	2004	2004	NUM
admet-854	543	5	)	)	PUNCT
admet-854	543	6	7663	7663	NUM
admet-854	543	7	-	-	SYM
admet-854	543	8	7671	7671	NUM
admet-854	543	9	.	.	PUNCT
admet-854	544	1	[	[	X
admet-854	544	2	36	36	NUM
admet-854	544	3	]	]	X
admet-854	544	4	c.h	c.h	PROPN
admet-854	544	5	.	.	PROPN
admet-854	544	6	silva	silva	PROPN
admet-854	544	7	,	,	PUNCT
admet-854	544	8	m.	m.	NOUN
admet-854	544	9	silva	silva	PROPN
admet-854	544	10	,	,	PUNCT
admet-854	544	11	j.	j.	PROPN
admet-854	544	12	iulek	iulek	PROPN
admet-854	544	13	,	,	PUNCT
admet-854	544	14	o.h	o.h	PROPN
admet-854	544	15	.	.	PROPN
admet-854	544	16	thiemann	thiemann	PROPN
admet-854	544	17	.	.	PUNCT
admet-854	545	1	structural	structural	ADJ
admet-854	545	2	complexes	complex	NOUN
admet-854	545	3	of	of	ADP
admet-854	545	4	human	human	ADJ
admet-854	545	5	adenine	adenine	NOUN
admet-854	545	6	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	545	7	reveal	reveal	VERB
admet-854	545	8	novel	novel	ADJ
admet-854	545	9	features	feature	NOUN
admet-854	545	10	of	of	ADP
admet-854	545	11	the	the	DET
admet-854	545	12	aprt	aprt	ADJ
admet-854	545	13	catalytic	catalytic	ADJ
admet-854	545	14	mechanism	mechanism	NOUN
admet-854	545	15	.	.	PUNCT
admet-854	546	1	j.	j.	PROPN
admet-854	546	2	biomol	biomol	PROPN
admet-854	546	3	.	.	PUNCT
admet-854	546	4	struct	struct	NOUN
admet-854	546	5	.	.	PUNCT
admet-854	547	1	dyn	dyn	NOUN
admet-854	547	2	.	.	PUNCT
admet-854	548	1	25	25	NUM
admet-854	548	2	(	(	PUNCT
admet-854	548	3	2008	2008	NUM
admet-854	548	4	)	)	PUNCT
admet-854	548	5	589	589	NUM
admet-854	548	6	-	-	SYM
admet-854	548	7	597	597	NUM
admet-854	548	8	.	.	PUNCT
admet-854	549	1	[	[	X
admet-854	549	2	37	37	NUM
admet-854	549	3	]	]	PUNCT
admet-854	549	4	j.	j.	PROPN
admet-854	549	5	huyet	huyet	PROPN
admet-854	549	6	,	,	PUNCT
admet-854	549	7	m.	m.	NOUN
admet-854	549	8	ozeir	ozeir	PROPN
admet-854	549	9	,	,	PUNCT
admet-854	549	10	m.c	m.c	PROPN
admet-854	549	11	.	.	PROPN
admet-854	549	12	burgevin	burgevin	PROPN
admet-854	549	13	,	,	PUNCT
admet-854	549	14	b.	b.	PROPN
admet-854	549	15	pinson	pinson	PROPN
admet-854	549	16	,	,	PUNCT
admet-854	549	17	f.	f.	PROPN
admet-854	549	18	chesney	chesney	PROPN
admet-854	549	19	,	,	PUNCT
admet-854	549	20	j.m	j.m	PROPN
admet-854	549	21	.	.	PROPN
admet-854	549	22	remy	remy	PROPN
admet-854	549	23	,	,	PUNCT
admet-854	549	24	a.r	a.r	PROPN
admet-854	549	25	.	.	PROPN
admet-854	549	26	siddiqi	siddiqi	PROPN
admet-854	549	27	,	,	PUNCT
admet-854	549	28	r.	r.	PROPN
admet-854	549	29	lupoli	lupoli	PROPN
admet-854	549	30	,	,	PUNCT
admet-854	549	31	g.	g.	PROPN
admet-854	549	32	pinon	pinon	PROPN
admet-854	549	33	,	,	PUNCT
admet-854	549	34	c.	c.	PROPN
admet-854	549	35	saint	saint	PROPN
admet-854	549	36	-	-	PUNCT
admet-854	549	37	marc	marc	PROPN
admet-854	549	38	,	,	PUNCT
admet-854	549	39	j.f	j.f	PROPN
admet-854	549	40	.	.	PROPN
admet-854	549	41	gibert	gibert	PROPN
admet-854	549	42	,	,	PUNCT
admet-854	549	43	r.	r.	PROPN
admet-854	549	44	morales	morales	PROPN
admet-854	549	45	,	,	PUNCT
admet-854	549	46	i.	i.	PROPN
admet-854	549	47	ceballos	ceballos	PROPN
admet-854	549	48	-	-	PUNCT
admet-854	549	49	picot	picot	PROPN
admet-854	549	50	,	,	PUNCT
admet-854	549	51	r.	r.	PROPN
admet-854	549	52	barouki	barouki	PROPN
admet-854	549	53	,	,	PUNCT
admet-854	549	54	b.	b.	PROPN
admet-854	549	55	daignan	daignan	PROPN
admet-854	549	56	-	-	PUNCT
admet-854	549	57	fornier	fornier	NOUN
admet-854	549	58	,	,	PUNCT
admet-854	549	59	a.	a.	NOUN
admet-854	549	60	olivierbandini	olivierbandini	NOUN
admet-854	549	61	,	,	PUNCT
admet-854	549	62	f.	f.	PROPN
admet-854	549	63	augé	augé	PROPN
admet-854	549	64	,	,	PUNCT
admet-854	549	65	p.	p.	NOUN
admet-854	549	66	nioche	nioche	NOUN
admet-854	549	67	.	.	PUNCT
admet-854	550	1	structural	structural	ADJ
admet-854	550	2	insights	insight	NOUN
admet-854	550	3	into	into	ADP
admet-854	550	4	the	the	DET
admet-854	550	5	forward	forward	NOUN
admet-854	550	6	and	and	CCONJ
admet-854	550	7	reverse	reverse	VERB
admet-854	550	8	enzymatic	enzymatic	ADJ
admet-854	550	9	reactions	reaction	NOUN
admet-854	550	10	in	in	ADP
admet-854	550	11	human	human	ADJ
admet-854	550	12	adenine	adenine	NOUN
admet-854	550	13	phosphoribosyltransferase	phosphoribosyltransferase	NOUN
admet-854	550	14	.	.	PUNCT
admet-854	551	1	cell	cell	NOUN
admet-854	551	2	chem	chem	NOUN
admet-854	551	3	.	.	PUNCT
admet-854	552	1	biol	biol	PROPN
admet-854	552	2	.	.	PUNCT
admet-854	553	1	25	25	NUM
admet-854	553	2	(	(	PUNCT
admet-854	553	3	2018	2018	NUM
admet-854	553	4	)	)	PUNCT
admet-854	553	5	666	666	NUM
admet-854	553	6	-	-	PUNCT
admet-854	553	7	676.e4	676.e4	NUM
admet-854	553	8	.	.	PUNCT
admet-854	554	1	[	[	X
admet-854	554	2	38	38	NUM
admet-854	554	3	]	]	PUNCT
admet-854	554	4	k.	k.	PROPN
admet-854	554	5	knapp	knapp	PROPN
admet-854	554	6	,	,	PUNCT
admet-854	554	7	m.	m.	PROPN
admet-854	554	8	zebisch	zebisch	PROPN
admet-854	554	9	,	,	PUNCT
admet-854	554	10	j.	j.	PROPN
admet-854	554	11	pippel	pippel	PROPN
admet-854	554	12	,	,	PUNCT
admet-854	554	13	a.	a.	PROPN
admet-854	554	14	el	el	PROPN
admet-854	554	15	-	-	PUNCT
admet-854	554	16	tayeb	tayeb	PROPN
admet-854	554	17	,	,	PUNCT
admet-854	554	18	c.e	c.e	PROPN
admet-854	554	19	.	.	PROPN
admet-854	554	20	müller	müller	PROPN
admet-854	554	21	,	,	PUNCT
admet-854	554	22	n.	n.	NOUN
admet-854	554	23	sträter	sträter	NOUN
admet-854	554	24	.	.	PUNCT
admet-854	555	1	crystal	crystal	NOUN
admet-854	555	2	structure	structure	NOUN
admet-854	555	3	of	of	ADP
admet-854	555	4	the	the	DET
admet-854	555	5	human	human	ADJ
admet-854	555	6	ecto-5'-nucleotidase	ecto-5'-nucleotidase	NOUN
admet-854	555	7	(	(	PUNCT
admet-854	555	8	cd73	cd73	PROPN
admet-854	555	9	):	):	PUNCT
admet-854	555	10	insights	insight	NOUN
admet-854	555	11	into	into	ADP
admet-854	555	12	the	the	DET
admet-854	555	13	regulation	regulation	NOUN
admet-854	555	14	of	of	ADP
admet-854	555	15	purinergic	purinergic	NOUN
admet-854	555	16	signaling	signal	VERB
admet-854	555	17	.	.	PUNCT
admet-854	556	1	structure	structure	NOUN
admet-854	556	2	20	20	NUM
admet-854	556	3	(	(	PUNCT
admet-854	556	4	2012	2012	NUM
admet-854	556	5	)	)	PUNCT
admet-854	556	6	2161	2161	NUM
admet-854	556	7	-	-	SYM
admet-854	556	8	2173	2173	NUM
admet-854	556	9	.	.	PUNCT
admet-854	557	1	[	[	X
admet-854	557	2	39	39	NUM
admet-854	557	3	]	]	X
admet-854	557	4	d.p	d.p	PROPN
admet-854	557	5	.	.	PROPN
admet-854	557	6	heuts	heuts	PROPN
admet-854	557	7	,	,	PUNCT
admet-854	557	8	m.j	m.j	PROPN
admet-854	557	9	.	.	PROPN
admet-854	557	10	weissenborn	weissenborn	PROPN
admet-854	557	11	,	,	PUNCT
admet-854	557	12	r.v	r.v	PROPN
admet-854	557	13	.	.	PROPN
admet-854	557	14	olkhov	olkhov	PROPN
admet-854	557	15	,	,	PUNCT
admet-854	557	16	a.m.	a.m.	PROPN
admet-854	557	17	shaw	shaw	PROPN
admet-854	557	18	,	,	PUNCT
admet-854	557	19	j.	j.	PROPN
admet-854	557	20	gummadova	gummadova	PROPN
admet-854	557	21	,	,	PUNCT
admet-854	557	22	c.	c.	PROPN
admet-854	557	23	levy	levy	PROPN
admet-854	557	24	,	,	PUNCT
admet-854	557	25	n.s	n.s	PROPN
admet-854	557	26	.	.	PROPN
admet-854	557	27	scrutton	scrutton	PROPN
admet-854	557	28	.	.	PUNCT
admet-854	558	1	crystal	crystal	NOUN
admet-854	558	2	structure	structure	NOUN
admet-854	558	3	of	of	ADP
admet-854	558	4	a	a	DET
admet-854	558	5	soluble	soluble	ADJ
admet-854	558	6	form	form	NOUN
admet-854	558	7	of	of	ADP
admet-854	558	8	human	human	ADJ
admet-854	558	9	cd73	cd73	PROPN
admet-854	558	10	with	with	ADP
admet-854	558	11	ecto-5'-nucleotidase	ecto-5'-nucleotidase	NOUN
admet-854	558	12	activity	activity	NOUN
admet-854	558	13	.	.	PUNCT
admet-854	559	1	chembiochem	chembiochem	PROPN
admet-854	559	2	13	13	NUM
admet-854	559	3	(	(	PUNCT
admet-854	559	4	2012	2012	NUM
admet-854	559	5	)	)	PUNCT
admet-854	559	6	2384	2384	NUM
admet-854	559	7	-	-	SYM
admet-854	559	8	2391	2391	NUM
admet-854	559	9	.	.	PUNCT
admet-854	560	1	[	[	X
admet-854	560	2	40	40	NUM
admet-854	560	3	]	]	X
admet-854	560	4	m.f	m.f	PROPN
admet-854	560	5	.	.	PROPN
admet-854	560	6	giraud	giraud	PROPN
admet-854	560	7	,	,	PUNCT
admet-854	560	8	f.	f.	PROPN
admet-854	560	9	georgescauld	georgescauld	PROPN
admet-854	560	10	,	,	PUNCT
admet-854	560	11	i.	i.	PROPN
admet-854	560	12	lascu	lascu	PROPN
admet-854	560	13	,	,	PUNCT
admet-854	560	14	a.	a.	NOUN
admet-854	560	15	dautant	dautant	PROPN
admet-854	560	16	.	.	PUNCT
admet-854	561	1	crystal	crystal	NOUN
admet-854	561	2	structures	structure	NOUN
admet-854	561	3	of	of	ADP
admet-854	561	4	s120	s120	PROPN
admet-854	561	5	g	g	NOUN
admet-854	561	6	mutant	mutant	NOUN
admet-854	561	7	and	and	CCONJ
admet-854	561	8	wild	wild	ADJ
admet-854	561	9	type	type	NOUN
admet-854	561	10	of	of	ADP
admet-854	561	11	human	human	ADJ
admet-854	561	12	nucleoside	nucleoside	PROPN
admet-854	561	13	diphosphate	diphosphate	PROPN
admet-854	561	14	kinase	kinase	PROPN
admet-854	561	15	a	a	PRON
admet-854	561	16	in	in	ADP
admet-854	561	17	complex	complex	NOUN
admet-854	561	18	with	with	ADP
admet-854	561	19	adp	adp	PROPN
admet-854	561	20	.	.	PUNCT
admet-854	561	21	j.	j.	PROPN
admet-854	561	22	bioenerg	bioenerg	PROPN
admet-854	561	23	.	.	PUNCT
admet-854	562	1	biomembr	biomembr	NOUN
admet-854	562	2	.	.	PUNCT
admet-854	563	1	38	38	NUM
admet-854	563	2	(	(	PUNCT
admet-854	563	3	2006	2006	NUM
admet-854	563	4	)	)	PUNCT
admet-854	563	5	261	261	NUM
admet-854	563	6	-	-	SYM
admet-854	563	7	264	264	NUM
admet-854	563	8	.	.	PUNCT
admet-854	564	1	[	[	X
admet-854	564	2	41	41	NUM
admet-854	564	3	]	]	PUNCT
admet-854	564	4	k.	k.	PROPN
admet-854	564	5	min	min	PROPN
admet-854	564	6	,	,	PUNCT
admet-854	564	7	h.k	h.k	PROPN
admet-854	564	8	.	.	PROPN
admet-854	564	9	song	song	PROPN
admet-854	564	10	,	,	PUNCT
admet-854	564	11	c.	c.	PROPN
admet-854	564	12	chang	chang	PROPN
admet-854	564	13	,	,	PUNCT
admet-854	564	14	s.y	s.y	PROPN
admet-854	564	15	.	.	PROPN
admet-854	565	1	kim	kim	PROPN
admet-854	565	2	,	,	PUNCT
admet-854	565	3	k.j	k.j	PROPN
admet-854	565	4	.	.	PROPN
admet-854	565	5	lee	lee	PROPN
admet-854	565	6	,	,	PUNCT
admet-854	565	7	s.w	s.w	PROPN
admet-854	565	8	.	.	PROPN
admet-854	565	9	suh	suh	PROPN
admet-854	565	10	.	.	PUNCT
admet-854	566	1	crystal	crystal	NOUN
admet-854	566	2	structure	structure	NOUN
admet-854	566	3	of	of	ADP
admet-854	566	4	human	human	ADJ
admet-854	566	5	nucleoside	nucleoside	PROPN
admet-854	566	6	diphosphate	diphosphate	PROPN
admet-854	566	7	kinase	kinase	PROPN
admet-854	566	8	a	a	X
admet-854	566	9	,	,	PUNCT
admet-854	566	10	a	a	DET
admet-854	566	11	metastasis	metastasis	NOUN
admet-854	566	12	suppressor	suppressor	NOUN
admet-854	566	13	.	.	PUNCT
admet-854	567	1	proteins	protein	NOUN
admet-854	567	2	46	46	NUM
admet-854	567	3	(	(	PUNCT
admet-854	567	4	2002	2002	NUM
admet-854	567	5	)	)	PUNCT
admet-854	567	6	340	340	NUM
admet-854	567	7	-	-	SYM
admet-854	567	8	342	342	NUM
admet-854	567	9	.	.	PUNCT
admet-854	568	1	[	[	X
admet-854	568	2	42	42	NUM
admet-854	568	3	]	]	X
admet-854	568	4	t.s	t.s	PROPN
admet-854	568	5	.	.	PROPN
admet-854	568	6	dexheimer	dexheimer	PROPN
admet-854	568	7	,	,	PUNCT
admet-854	568	8	s.s	s.s	PROPN
admet-854	568	9	.	.	PROPN
admet-854	568	10	carey	carey	PROPN
admet-854	568	11	,	,	PUNCT
admet-854	568	12	s.	s.	PROPN
admet-854	568	13	zuohe	zuohe	PROPN
admet-854	568	14	,	,	PUNCT
admet-854	568	15	v.m	v.m	PROPN
admet-854	568	16	.	.	PROPN
admet-854	568	17	gokhale	gokhale	PROPN
admet-854	568	18	,	,	PUNCT
admet-854	568	19	x.	x.	PROPN
admet-854	568	20	hu	hu	PROPN
admet-854	568	21	,	,	PUNCT
admet-854	568	22	l.b	l.b	PROPN
admet-854	568	23	.	.	PROPN
admet-854	568	24	murata	murata	PROPN
admet-854	568	25	,	,	PUNCT
admet-854	568	26	e.m	e.m	PROPN
admet-854	568	27	.	.	PROPN
admet-854	568	28	maes	maes	PROPN
admet-854	568	29	,	,	PUNCT
admet-854	568	30	a.	a.	NOUN
admet-854	568	31	weichsel	weichsel	PROPN
admet-854	568	32	,	,	PUNCT
admet-854	568	33	d.	d.	PROPN
admet-854	568	34	sun	sun	PROPN
admet-854	568	35	,	,	PUNCT
admet-854	568	36	e.j	e.j	PROPN
admet-854	568	37	.	.	PROPN
admet-854	568	38	meuillet	meuillet	PROPN
admet-854	568	39	,	,	PUNCT
admet-854	568	40	w.r	w.r	PROPN
admet-854	568	41	.	.	PROPN
admet-854	568	42	montfort	montfort	PROPN
admet-854	568	43	,	,	PUNCT
admet-854	568	44	l.h	l.h	PROPN
admet-854	568	45	.	.	PROPN
admet-854	568	46	hurley	hurley	PROPN
admet-854	568	47	.	.	PUNCT
admet-854	569	1	nm23	nm23	PROPN
admet-854	569	2	-	-	PUNCT
admet-854	569	3	h2	h2	NOUN
admet-854	569	4	may	may	AUX
admet-854	569	5	play	play	VERB
admet-854	569	6	an	an	DET
admet-854	569	7	indirect	indirect	ADJ
admet-854	569	8	role	role	NOUN
admet-854	569	9	in	in	ADP
admet-854	569	10	transcriptional	transcriptional	ADJ
admet-854	569	11	activation	activation	NOUN
admet-854	569	12	of	of	ADP
admet-854	569	13	c	c	NOUN
admet-854	569	14	-	-	PUNCT
admet-854	569	15	myc	myc	NOUN
admet-854	569	16	gene	gene	NOUN
admet-854	569	17	expression	expression	NOUN
admet-854	569	18	but	but	CCONJ
admet-854	569	19	does	do	AUX
admet-854	569	20	not	not	PART
admet-854	569	21	cleave	cleave	VERB
admet-854	569	22	the	the	DET
admet-854	569	23	nuclease	nuclease	NOUN
admet-854	569	24	hypersensitive	hypersensitive	ADJ
admet-854	569	25	element	element	NOUN
admet-854	569	26	iii(1	iii(1	NOUN
admet-854	569	27	)	)	PUNCT
admet-854	569	28	.	.	PUNCT
admet-854	570	1	mol	mol	PROPN
admet-854	570	2	.	.	PUNCT
admet-854	571	1	cancer	cancer	NOUN
admet-854	571	2	ther	ther	PROPN
admet-854	571	3	.	.	PUNCT
admet-854	572	1	8	8	NUM
admet-854	572	2	(	(	PUNCT
admet-854	572	3	2009	2009	NUM
admet-854	572	4	)	)	PUNCT
admet-854	572	5	1363	1363	NUM
admet-854	572	6	-	-	SYM
admet-854	572	7	1377	1377	NUM
admet-854	572	8	.	.	PUNCT
admet-854	573	1	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	573	2	mihaela	mihaela	PROPN
admet-854	573	3	ileana	ileana	PROPN
admet-854	573	4	ionescu	ionescu	PROPN
admet-854	573	5	admet	admet	PROPN
admet-854	573	6	&	&	CCONJ
admet-854	573	7	dmpk	dmpk	PROPN
admet-854	573	8	8(2	8(2	NUM
admet-854	573	9	)	)	PUNCT
admet-854	573	10	(	(	PUNCT
admet-854	573	11	2020	2020	NUM
admet-854	573	12	)	)	PUNCT
admet-854	573	13	149	149	NUM
admet-854	573	14	-	-	SYM
admet-854	573	15	175	175	NUM
admet-854	573	16	172	172	NUM
admet-854	573	17	[	[	X
admet-854	573	18	43	43	NUM
admet-854	573	19	]	]	X
admet-854	573	20	s.e	s.e	PROPN
admet-854	573	21	.	.	PROPN
admet-854	573	22	ealick	ealick	PROPN
admet-854	573	23	,	,	PUNCT
admet-854	573	24	y.s	y.s	PROPN
admet-854	573	25	.	.	PROPN
admet-854	573	26	babu	babu	PROPN
admet-854	573	27	,	,	PUNCT
admet-854	573	28	c.e	c.e	PROPN
admet-854	573	29	.	.	PROPN
admet-854	573	30	bugg	bugg	NOUN
admet-854	573	31	,	,	PUNCT
admet-854	573	32	m.d	m.d	PROPN
admet-854	573	33	.	.	PROPN
admet-854	573	34	erion	erion	NOUN
admet-854	573	35	,	,	PUNCT
admet-854	573	36	w.g	w.g	PROPN
admet-854	573	37	.	.	PROPN
admet-854	573	38	guida	guida	PROPN
admet-854	573	39	,	,	PUNCT
admet-854	573	40	j.a	j.a	PROPN
admet-854	573	41	.	.	PROPN
admet-854	573	42	montgomery	montgomery	PROPN
admet-854	573	43	,	,	PUNCT
admet-854	573	44	j.a	j.a	PROPN
admet-854	573	45	.	.	PROPN
admet-854	573	46	secrist	secrist	PROPN
admet-854	573	47	.	.	PUNCT
admet-854	574	1	application	application	NOUN
admet-854	574	2	of	of	ADP
admet-854	574	3	x	x	ADJ
admet-854	574	4	-	-	NOUN
admet-854	574	5	ray	ray	NOUN
admet-854	574	6	crystallographic	crystallographic	ADJ
admet-854	574	7	methods	method	NOUN
admet-854	574	8	in	in	ADP
admet-854	574	9	the	the	DET
admet-854	574	10	design	design	NOUN
admet-854	574	11	of	of	ADP
admet-854	574	12	purine	purine	NOUN
admet-854	574	13	nucleoside	nucleoside	NOUN
admet-854	574	14	phosphorylase	phosphorylase	NOUN
admet-854	574	15	inhibitors	inhibitor	NOUN
admet-854	574	16	.	.	PUNCT
admet-854	575	1	ann	ann	PROPN
admet-854	575	2	.	.	PUNCT
admet-854	575	3	n.	n.	PROPN
admet-854	575	4	y.	y.	PROPN
admet-854	575	5	acad	acad	PROPN
admet-854	575	6	.	.	PUNCT
admet-854	576	1	sci	sci	PROPN
admet-854	576	2	.	.	PROPN
admet-854	576	3	685	685	NUM
admet-854	576	4	(	(	PUNCT
admet-854	576	5	1993	1993	NUM
admet-854	576	6	)	)	PUNCT
admet-854	576	7	237	237	NUM
admet-854	576	8	-	-	SYM
admet-854	576	9	247	247	NUM
admet-854	576	10	.	.	PUNCT
admet-854	577	1	[	[	X
admet-854	577	2	44	44	NUM
admet-854	577	3	]	]	X
admet-854	577	4	a.s	a.s	PROPN
admet-854	577	5	.	.	PROPN
admet-854	577	6	murkin	murkin	PROPN
admet-854	577	7	,	,	PUNCT
admet-854	577	8	m.r	m.r	PROPN
admet-854	577	9	.	.	PROPN
admet-854	577	10	birck	birck	PROPN
admet-854	577	11	,	,	PUNCT
admet-854	577	12	a.	a.	NOUN
admet-854	577	13	rinaldo	rinaldo	PROPN
admet-854	577	14	-	-	PROPN
admet-854	577	15	matthis	matthis	PROPN
admet-854	577	16	,	,	PUNCT
admet-854	577	17	w.	w.	PROPN
admet-854	577	18	shi	shi	PROPN
admet-854	577	19	,	,	PUNCT
admet-854	577	20	e.a	e.a	PROPN
admet-854	577	21	.	.	PROPN
admet-854	577	22	taylor	taylor	PROPN
admet-854	577	23	,	,	PUNCT
admet-854	577	24	s.c	s.c	PROPN
admet-854	577	25	.	.	PROPN
admet-854	577	26	almo	almo	PROPN
admet-854	577	27	,	,	PUNCT
admet-854	577	28	v.l	v.l	PROPN
admet-854	577	29	.	.	PROPN
admet-854	577	30	schramm	schramm	PROPN
admet-854	577	31	.	.	PUNCT
admet-854	578	1	neighboring	neighboring	NOUN
admet-854	578	2	group	group	NOUN
admet-854	578	3	participation	participation	NOUN
admet-854	578	4	in	in	ADP
admet-854	578	5	the	the	DET
admet-854	578	6	transition	transition	NOUN
admet-854	578	7	state	state	NOUN
admet-854	578	8	of	of	ADP
admet-854	578	9	human	human	ADJ
admet-854	578	10	purine	purine	NOUN
admet-854	578	11	nucleoside	nucleoside	NOUN
admet-854	578	12	phosphorylase	phosphorylase	NOUN
admet-854	578	13	.	.	PUNCT
admet-854	579	1	biochemistry	biochemistry	NOUN
admet-854	579	2	46	46	NUM
admet-854	579	3	(	(	PUNCT
admet-854	579	4	2007	2007	NUM
admet-854	579	5	)	)	PUNCT
admet-854	579	6	5038	5038	NUM
admet-854	579	7	-	-	SYM
admet-854	579	8	5049	5049	NUM
admet-854	579	9	.	.	PUNCT
admet-854	580	1	[	[	X
admet-854	580	2	45	45	NUM
admet-854	580	3	]	]	PUNCT
admet-854	580	4	f.	f.	PROPN
admet-854	580	5	canduri	canduri	PROPN
admet-854	580	6	,	,	PUNCT
admet-854	580	7	r.g	r.g	PROPN
admet-854	580	8	.	.	PROPN
admet-854	580	9	silva	silva	PROPN
admet-854	580	10	,	,	PUNCT
admet-854	580	11	d.m	d.m	PROPN
admet-854	580	12	.	.	PROPN
admet-854	580	13	dos	dos	PROPN
admet-854	580	14	santos	santos	PROPN
admet-854	580	15	,	,	PUNCT
admet-854	580	16	m.s	m.s	PROPN
admet-854	580	17	.	.	PROPN
admet-854	580	18	palma	palma	PROPN
admet-854	580	19	,	,	PUNCT
admet-854	580	20	l.a	l.a	PROPN
admet-854	580	21	.	.	PROPN
admet-854	580	22	basso	basso	PROPN
admet-854	580	23	,	,	PUNCT
admet-854	580	24	d.s	d.s	PROPN
admet-854	580	25	.	.	PROPN
admet-854	580	26	santos	santos	PROPN
admet-854	580	27	,	,	PUNCT
admet-854	580	28	w.f	w.f	PROPN
admet-854	580	29	.	.	PROPN
admet-854	580	30	de	de	PROPN
admet-854	580	31	azevedo	azevedo	PROPN
admet-854	580	32	.	.	PUNCT
admet-854	581	1	structure	structure	NOUN
admet-854	581	2	of	of	ADP
admet-854	581	3	human	human	PROPN
admet-854	581	4	pnp	pnp	PROPN
admet-854	581	5	complexed	complexe	VERB
admet-854	581	6	with	with	ADP
admet-854	581	7	ligands	ligand	NOUN
admet-854	581	8	.	.	PUNCT
admet-854	582	1	acta	acta	PROPN
admet-854	582	2	crystallogr	crystallogr	PROPN
admet-854	582	3	.	.	PUNCT
admet-854	583	1	d	d	X
admet-854	583	2	biol	biol	PROPN
admet-854	583	3	.	.	PUNCT
admet-854	584	1	crystallogr	crystallogr	PROPN
admet-854	584	2	.	.	PUNCT
admet-854	585	1	61	61	NUM
admet-854	585	2	(	(	PUNCT
admet-854	585	3	2005	2005	NUM
admet-854	585	4	)	)	PUNCT
admet-854	585	5	856862	856862	NUM
admet-854	585	6	.	.	PUNCT
admet-854	586	1	[	[	X
admet-854	586	2	46	46	NUM
admet-854	586	3	]	]	PUNCT
admet-854	586	4	k.	k.	PROPN
admet-854	586	5	fritz	fritz	PROPN
admet-854	586	6	-	-	PUNCT
admet-854	586	7	wolf	wolf	PROPN
admet-854	586	8	,	,	PUNCT
admet-854	586	9	t.	t.	NOUN
admet-854	586	10	schnyder	schnyder	NOUN
admet-854	586	11	,	,	PUNCT
admet-854	586	12	t.	t.	NOUN
admet-854	586	13	wallimann	wallimann	PROPN
admet-854	586	14	,	,	PUNCT
admet-854	586	15	w.	w.	PROPN
admet-854	586	16	kabsch	kabsch	PROPN
admet-854	586	17	.	.	PUNCT
admet-854	587	1	structure	structure	NOUN
admet-854	587	2	of	of	ADP
admet-854	587	3	mitochondrial	mitochondrial	ADJ
admet-854	587	4	creatine	creatine	PROPN
admet-854	587	5	kinase	kinase	PROPN
admet-854	587	6	.	.	PUNCT
admet-854	588	1	nature	nature	NOUN
admet-854	588	2	381	381	NUM
admet-854	588	3	(	(	PUNCT
admet-854	588	4	1996	1996	NUM
admet-854	588	5	)	)	PUNCT
admet-854	588	6	341	341	NUM
admet-854	588	7	-	-	SYM
admet-854	588	8	345	345	NUM
admet-854	588	9	.	.	PUNCT
admet-854	589	1	[	[	X
admet-854	589	2	47	47	NUM
admet-854	589	3	]	]	X
admet-854	589	4	j.k	j.k	PROPN
admet-854	589	5	.	.	PROPN
admet-854	589	6	rao	rao	PROPN
admet-854	589	7	,	,	PUNCT
admet-854	589	8	g.	g.	PROPN
admet-854	589	9	bujacz	bujacz	NOUN
admet-854	589	10	,	,	PUNCT
admet-854	589	11	a.	a.	NOUN
admet-854	589	12	wlodawer	wlodawer	NOUN
admet-854	589	13	.	.	PUNCT
admet-854	590	1	crystal	crystal	NOUN
admet-854	590	2	structure	structure	NOUN
admet-854	590	3	of	of	ADP
admet-854	590	4	rabbit	rabbit	NOUN
admet-854	590	5	muscle	muscle	NOUN
admet-854	590	6	creatine	creatine	PROPN
admet-854	590	7	kinase	kinase	PROPN
admet-854	590	8	.	.	PUNCT
admet-854	591	1	febs	febs	PROPN
admet-854	591	2	lett	lett	PROPN
admet-854	591	3	.	.	PUNCT
admet-854	592	1	439	439	NUM
admet-854	592	2	(	(	PUNCT
admet-854	592	3	1998	1998	NUM
admet-854	592	4	)	)	PUNCT
admet-854	592	5	133	133	NUM
admet-854	592	6	-	-	SYM
admet-854	592	7	137	137	NUM
admet-854	592	8	.	.	PUNCT
admet-854	593	1	[	[	X
admet-854	593	2	48	48	NUM
admet-854	593	3	]	]	X
admet-854	593	4	y.q	y.q	PROPN
admet-854	593	5	.	.	PROPN
admet-854	593	6	shen	shen	PROPN
admet-854	593	7	,	,	PUNCT
admet-854	593	8	l.	l.	PROPN
admet-854	593	9	tang	tang	PROPN
admet-854	593	10	,	,	PUNCT
admet-854	593	11	h.m	h.m	PROPN
admet-854	593	12	.	.	PROPN
admet-854	593	13	zhou	zhou	PROPN
admet-854	593	14	,	,	PUNCT
admet-854	593	15	z.j	z.j	PROPN
admet-854	593	16	.	.	PROPN
admet-854	593	17	lin	lin	PROPN
admet-854	593	18	.	.	PUNCT
admet-854	594	1	structure	structure	NOUN
admet-854	594	2	of	of	ADP
admet-854	594	3	human	human	ADJ
admet-854	594	4	muscle	muscle	NOUN
admet-854	594	5	creatine	creatine	PROPN
admet-854	594	6	kinase	kinase	PROPN
admet-854	594	7	.	.	PUNCT
admet-854	595	1	acta	acta	PROPN
admet-854	595	2	crystallogr	crystallogr	PROPN
admet-854	595	3	.	.	PUNCT
admet-854	596	1	d	d	X
admet-854	596	2	biol	biol	PROPN
admet-854	596	3	.	.	PUNCT
admet-854	597	1	crystallogr	crystallogr	PROPN
admet-854	597	2	.	.	PUNCT
admet-854	598	1	57	57	NUM
admet-854	598	2	(	(	PUNCT
admet-854	598	3	2001	2001	NUM
admet-854	598	4	)	)	PUNCT
admet-854	598	5	1196	1196	NUM
admet-854	598	6	-	-	SYM
admet-854	598	7	1200	1200	NUM
admet-854	598	8	.	.	PUNCT
admet-854	599	1	[	[	X
admet-854	599	2	49	49	NUM
admet-854	599	3	]	]	X
admet-854	599	4	j.f	j.f	PROPN
admet-854	599	5	.	.	PROPN
admet-854	599	6	ohren	ohren	PROPN
admet-854	599	7	,	,	PUNCT
admet-854	599	8	m.l	m.l	PROPN
admet-854	599	9	.	.	PROPN
admet-854	599	10	kundracik	kundracik	PROPN
admet-854	599	11	,	,	PUNCT
admet-854	599	12	c.l	c.l	PROPN
admet-854	599	13	.	.	PROPN
admet-854	599	14	borders	border	NOUN
admet-854	599	15	,	,	PUNCT
admet-854	599	16	p.	p.	PROPN
admet-854	599	17	edmiston	edmiston	PROPN
admet-854	599	18	,	,	PUNCT
admet-854	599	19	r.e	r.e	PROPN
admet-854	599	20	.	.	PROPN
admet-854	599	21	viola	viola	PROPN
admet-854	599	22	.	.	PUNCT
admet-854	600	1	structural	structural	ADJ
admet-854	600	2	asymmetry	asymmetry	NOUN
admet-854	600	3	and	and	CCONJ
admet-854	600	4	intersubunit	intersubunit	ADJ
admet-854	600	5	communication	communication	NOUN
admet-854	600	6	in	in	ADP
admet-854	600	7	muscle	muscle	NOUN
admet-854	600	8	creatine	creatine	PROPN
admet-854	600	9	kinase	kinase	PROPN
admet-854	600	10	.	.	PUNCT
admet-854	601	1	acta	acta	PROPN
admet-854	601	2	crystallogr	crystallogr	PROPN
admet-854	601	3	.	.	PUNCT
admet-854	602	1	d	d	X
admet-854	602	2	biol	biol	PROPN
admet-854	602	3	.	.	PUNCT
admet-854	603	1	crystallogr	crystallogr	PROPN
admet-854	603	2	.	.	PUNCT
admet-854	604	1	63	63	NUM
admet-854	604	2	(	(	PUNCT
admet-854	604	3	2007	2007	NUM
admet-854	604	4	)	)	PUNCT
admet-854	604	5	381	381	NUM
admet-854	604	6	-	-	SYM
admet-854	604	7	389	389	NUM
admet-854	604	8	.	.	PUNCT
admet-854	605	1	[	[	X
admet-854	605	2	50	50	NUM
admet-854	605	3	]	]	SYM
admet-854	605	4	s.m	s.m	PROPN
admet-854	605	5	.	.	PROPN
admet-854	605	6	bong	bong	PROPN
admet-854	605	7	,	,	PUNCT
admet-854	605	8	j.h	j.h	PROPN
admet-854	605	9	.	.	PROPN
admet-854	605	10	moon	moon	PROPN
admet-854	605	11	,	,	PUNCT
admet-854	605	12	k.h	k.h	PROPN
admet-854	605	13	.	.	PROPN
admet-854	605	14	nam	nam	PROPN
admet-854	605	15	,	,	PUNCT
admet-854	605	16	k.s	k.s	PROPN
admet-854	605	17	.	.	PROPN
admet-854	605	18	lee	lee	PROPN
admet-854	605	19	,	,	PUNCT
admet-854	605	20	y.m	y.m	PROPN
admet-854	605	21	.	.	PROPN
admet-854	605	22	chi	chi	PROPN
admet-854	605	23	,	,	PUNCT
admet-854	605	24	k.y	k.y	PROPN
admet-854	605	25	.	.	PROPN
admet-854	605	26	hwang	hwang	PROPN
admet-854	605	27	.	.	PUNCT
admet-854	606	1	structural	structural	ADJ
admet-854	606	2	studies	study	NOUN
admet-854	606	3	of	of	ADP
admet-854	606	4	human	human	ADJ
admet-854	606	5	braintype	braintype	PROPN
admet-854	606	6	creatine	creatine	PROPN
admet-854	606	7	kinase	kinase	PROPN
admet-854	606	8	complexed	complexe	VERB
admet-854	606	9	with	with	ADP
admet-854	606	10	the	the	DET
admet-854	606	11	adp	adp	PROPN
admet-854	606	12	-	-	PUNCT
admet-854	606	13	mg2	mg2	PROPN
admet-854	606	14	+	+	PROPN
admet-854	606	15	-no3	-no3	ADJ
admet-854	606	16	-	-	PUNCT
admet-854	606	17	creatine	creatine	NOUN
admet-854	606	18	transition	transition	NOUN
admet-854	606	19	-	-	PUNCT
admet-854	606	20	state	state	NOUN
admet-854	606	21	analogue	analogue	NOUN
admet-854	606	22	complex	complex	NOUN
admet-854	606	23	.	.	PUNCT
admet-854	607	1	febs	febs	PROPN
admet-854	607	2	lett	lett	PROPN
admet-854	607	3	.	.	PUNCT
admet-854	608	1	582	582	NUM
admet-854	608	2	(	(	PUNCT
admet-854	608	3	2008	2008	NUM
admet-854	608	4	)	)	PUNCT
admet-854	608	5	3959	3959	NUM
admet-854	608	6	-	-	SYM
admet-854	608	7	3965	3965	NUM
admet-854	608	8	.	.	PUNCT
admet-854	609	1	[	[	X
admet-854	609	2	51	51	NUM
admet-854	609	3	]	]	PUNCT
admet-854	609	4	m.	m.	NOUN
admet-854	609	5	eder	eder	NOUN
admet-854	609	6	,	,	PUNCT
admet-854	609	7	u.	u.	PROPN
admet-854	609	8	schlattner	schlattner	PROPN
admet-854	609	9	,	,	PUNCT
admet-854	609	10	a.	a.	NOUN
admet-854	609	11	becker	becker	PROPN
admet-854	609	12	,	,	PUNCT
admet-854	609	13	t.	t.	NOUN
admet-854	609	14	wallimann	wallimann	PROPN
admet-854	609	15	,	,	PUNCT
admet-854	609	16	w.	w.	PROPN
admet-854	609	17	kabsch	kabsch	PROPN
admet-854	609	18	,	,	PUNCT
admet-854	609	19	k.	k.	PROPN
admet-854	609	20	fritz	fritz	PROPN
admet-854	609	21	-	-	PUNCT
admet-854	609	22	wolf	wolf	PROPN
admet-854	609	23	.	.	PUNCT
admet-854	610	1	crystal	crystal	NOUN
admet-854	610	2	structure	structure	NOUN
admet-854	610	3	of	of	ADP
admet-854	610	4	braintype	braintype	PROPN
admet-854	610	5	creatine	creatine	PROPN
admet-854	610	6	kinase	kinase	PROPN
admet-854	610	7	at	at	ADP
admet-854	610	8	1.41	1.41	NUM
admet-854	610	9	a	a	DET
admet-854	610	10	resolution	resolution	NOUN
admet-854	610	11	.	.	PUNCT
admet-854	611	1	protein	protein	NOUN
admet-854	611	2	sci	sci	PROPN
admet-854	611	3	.	.	PROPN
admet-854	611	4	8	8	NUM
admet-854	611	5	(	(	PUNCT
admet-854	611	6	1999	1999	NUM
admet-854	611	7	)	)	PUNCT
admet-854	611	8	2258	2258	NUM
admet-854	611	9	-	-	SYM
admet-854	611	10	2269	2269	NUM
admet-854	611	11	.	.	PUNCT
admet-854	612	1	[	[	X
admet-854	612	2	52	52	NUM
admet-854	612	3	]	]	X
admet-854	612	4	d.	d.	PROPN
admet-854	612	5	tisi	tisi	PROPN
admet-854	612	6	,	,	PUNCT
admet-854	612	7	b.	b.	PROPN
admet-854	612	8	bax	bax	PROPN
admet-854	612	9	,	,	PUNCT
admet-854	612	10	a.	a.	PROPN
admet-854	612	11	loew	loew	PROPN
admet-854	612	12	.	.	PUNCT
admet-854	613	1	the	the	DET
admet-854	613	2	three	three	NUM
admet-854	613	3	-	-	PUNCT
admet-854	613	4	dimensional	dimensional	ADJ
admet-854	613	5	structure	structure	NOUN
admet-854	613	6	of	of	ADP
admet-854	613	7	cytosolic	cytosolic	PROPN
admet-854	613	8	bovine	bovine	PROPN
admet-854	613	9	retinal	retinal	PROPN
admet-854	613	10	creatine	creatine	PROPN
admet-854	613	11	kinase	kinase	PROPN
admet-854	613	12	.	.	PUNCT
admet-854	614	1	acta	acta	PROPN
admet-854	614	2	crystallogr	crystallogr	PROPN
admet-854	614	3	.	.	PUNCT
admet-854	615	1	d	d	X
admet-854	615	2	biol	biol	PROPN
admet-854	615	3	.	.	PUNCT
admet-854	616	1	crystallogr	crystallogr	PROPN
admet-854	616	2	.	.	PUNCT
admet-854	617	1	57	57	NUM
admet-854	617	2	(	(	PUNCT
admet-854	617	3	2001	2001	NUM
admet-854	617	4	)	)	PUNCT
admet-854	617	5	187	187	NUM
admet-854	617	6	-	-	SYM
admet-854	617	7	193	193	NUM
admet-854	617	8	.	.	PUNCT
admet-854	618	1	[	[	X
admet-854	618	2	53	53	NUM
admet-854	618	3	]	]	X
admet-854	618	4	d.s	d.s	PROPN
admet-854	618	5	.	.	PROPN
admet-854	618	6	goodsell	goodsell	PROPN
admet-854	618	7	,	,	PUNCT
admet-854	618	8	a.j	a.j	PROPN
admet-854	618	9	.	.	PROPN
admet-854	618	10	olson	olson	PROPN
admet-854	618	11	.	.	PUNCT
admet-854	619	1	automated	automate	VERB
admet-854	619	2	docking	docking	NOUN
admet-854	619	3	of	of	ADP
admet-854	619	4	substrates	substrate	NOUN
admet-854	619	5	to	to	ADP
admet-854	619	6	proteins	protein	NOUN
admet-854	619	7	by	by	ADP
admet-854	619	8	simulated	simulated	ADJ
admet-854	619	9	annealing	annealing	NOUN
admet-854	619	10	.	.	PUNCT
admet-854	620	1	proteins	protein	NOUN
admet-854	620	2	8	8	NUM
admet-854	620	3	(	(	PUNCT
admet-854	620	4	1990	1990	NUM
admet-854	620	5	)	)	PUNCT
admet-854	620	6	195	195	NUM
admet-854	620	7	-	-	SYM
admet-854	620	8	202	202	NUM
admet-854	620	9	.	.	PUNCT
admet-854	621	1	[	[	X
admet-854	621	2	54	54	NUM
admet-854	621	3	]	]	SYM
admet-854	621	4	g.m	g.m	PROPN
admet-854	621	5	.	.	PROPN
admet-854	621	6	morris	morris	PROPN
admet-854	621	7	,	,	PUNCT
admet-854	621	8	r.	r.	PROPN
admet-854	621	9	huey	huey	PROPN
admet-854	621	10	,	,	PUNCT
admet-854	621	11	w.	w.	PROPN
admet-854	621	12	lindstrom	lindstrom	PROPN
admet-854	621	13	,	,	PUNCT
admet-854	621	14	m.f	m.f	PROPN
admet-854	621	15	.	.	PROPN
admet-854	621	16	sanner	sanner	PROPN
admet-854	621	17	,	,	PUNCT
admet-854	621	18	r.k	r.k	PROPN
admet-854	621	19	.	.	PROPN
admet-854	621	20	belew	belew	PROPN
admet-854	621	21	,	,	PUNCT
admet-854	621	22	d.s	d.s	PROPN
admet-854	621	23	.	.	PROPN
admet-854	621	24	goodsell	goodsell	PROPN
admet-854	621	25	,	,	PUNCT
admet-854	621	26	a.j	a.j	PROPN
admet-854	621	27	.	.	PROPN
admet-854	621	28	olson	olson	PROPN
admet-854	621	29	.	.	PUNCT
admet-854	622	1	autodock4	autodock4	PROPN
admet-854	622	2	and	and	CCONJ
admet-854	622	3	autodocktools4	autodocktools4	NOUN
admet-854	622	4	:	:	PUNCT
admet-854	622	5	automated	automate	VERB
admet-854	622	6	docking	docking	NOUN
admet-854	622	7	with	with	ADP
admet-854	622	8	selective	selective	ADJ
admet-854	622	9	receptor	receptor	NOUN
admet-854	622	10	flexibility	flexibility	NOUN
admet-854	622	11	.	.	PUNCT
admet-854	623	1	j.	j.	PROPN
admet-854	623	2	comput	comput	PROPN
admet-854	623	3	.	.	PUNCT
admet-854	624	1	chem	chem	NOUN
admet-854	624	2	.	.	PUNCT
admet-854	625	1	30	30	NUM
admet-854	625	2	(	(	PUNCT
admet-854	625	3	2009	2009	NUM
admet-854	625	4	)	)	PUNCT
admet-854	625	5	2785	2785	NUM
admet-854	625	6	-	-	SYM
admet-854	625	7	2791	2791	NUM
admet-854	625	8	.	.	PUNCT
admet-854	626	1	[	[	X
admet-854	626	2	55	55	NUM
admet-854	626	3	]	]	X
admet-854	626	4	s.m	s.m	PROPN
admet-854	626	5	.	.	PROPN
admet-854	626	6	rizvi	rizvi	PROPN
admet-854	626	7	,	,	PUNCT
admet-854	626	8	s.	s.	PROPN
admet-854	626	9	shakil	shakil	PROPN
admet-854	626	10	,	,	PUNCT
admet-854	626	11	m.	m.	NOUN
admet-854	626	12	haneef	haneef	PROPN
admet-854	626	13	.	.	PUNCT
admet-854	627	1	a	a	DET
admet-854	627	2	simple	simple	ADJ
admet-854	627	3	click	click	NOUN
admet-854	627	4	by	by	ADP
admet-854	627	5	click	click	NOUN
admet-854	627	6	protocol	protocol	NOUN
admet-854	627	7	to	to	PART
admet-854	627	8	perform	perform	VERB
admet-854	627	9	docking	docking	NOUN
admet-854	627	10	:	:	PUNCT
admet-854	627	11	autodock	autodock	NOUN
admet-854	627	12	4.2	4.2	NUM
admet-854	627	13	made	make	VERB
admet-854	627	14	easy	easy	ADJ
admet-854	627	15	for	for	ADP
admet-854	627	16	non	non	NOUN
admet-854	627	17	-	-	NOUN
admet-854	627	18	bioinformaticians	bioinformatician	NOUN
admet-854	627	19	.	.	PUNCT
admet-854	628	1	excli	excli	PROPN
admet-854	628	2	j	j	PROPN
admet-854	628	3	12	12	NUM
admet-854	628	4	(	(	PUNCT
admet-854	628	5	2013	2013	NUM
admet-854	628	6	)	)	PUNCT
admet-854	628	7	831	831	NUM
admet-854	628	8	-	-	SYM
admet-854	628	9	857	857	NUM
admet-854	628	10	.	.	PUNCT
admet-854	629	1	[	[	X
admet-854	629	2	56	56	NUM
admet-854	629	3	]	]	X
admet-854	629	4	m.b	m.b	PROPN
admet-854	629	5	.	.	PROPN
admet-854	629	6	berry	berry	PROPN
admet-854	629	7	,	,	PUNCT
admet-854	629	8	b.	b.	PROPN
admet-854	629	9	meador	meador	PROPN
admet-854	629	10	,	,	PUNCT
admet-854	629	11	t.	t.	NOUN
admet-854	629	12	bilderback	bilderback	NOUN
admet-854	629	13	,	,	PUNCT
admet-854	629	14	p.	p.	PROPN
admet-854	629	15	liang	liang	PROPN
admet-854	629	16	,	,	PUNCT
admet-854	629	17	m.	m.	PROPN
admet-854	629	18	glaser	glaser	PROPN
admet-854	629	19	,	,	PUNCT
admet-854	629	20	g.n	g.n	PROPN
admet-854	629	21	.	.	PROPN
admet-854	629	22	phillips	phillips	PROPN
admet-854	629	23	.	.	PUNCT
admet-854	630	1	the	the	DET
admet-854	630	2	closed	closed	ADJ
admet-854	630	3	conformation	conformation	NOUN
admet-854	630	4	of	of	ADP
admet-854	630	5	a	a	DET
admet-854	630	6	highly	highly	ADV
admet-854	630	7	flexible	flexible	ADJ
admet-854	630	8	protein	protein	NOUN
admet-854	630	9	:	:	PUNCT
admet-854	630	10	the	the	DET
admet-854	630	11	structure	structure	NOUN
admet-854	630	12	of	of	ADP
admet-854	630	13	e.	e.	PROPN
admet-854	630	14	coli	coli	PROPN
admet-854	630	15	adenylate	adenylate	ADJ
admet-854	630	16	kinase	kinase	NOUN
admet-854	630	17	with	with	ADP
admet-854	630	18	bound	bind	VERB
admet-854	630	19	amp	amp	NOUN
admet-854	630	20	and	and	CCONJ
admet-854	630	21	amppnp	amppnp	NOUN
admet-854	630	22	.	.	PUNCT
admet-854	631	1	proteins	protein	NOUN
admet-854	631	2	19	19	NUM
admet-854	631	3	(	(	PUNCT
admet-854	631	4	1994	1994	NUM
admet-854	631	5	)	)	PUNCT
admet-854	631	6	183	183	NUM
admet-854	631	7	-	-	SYM
admet-854	631	8	198	198	NUM
admet-854	631	9	.	.	PUNCT
admet-854	632	1	[	[	X
admet-854	632	2	57	57	NUM
admet-854	632	3	]	]	X
admet-854	632	4	p.	p.	NOUN
admet-854	632	5	rogne	rogne	PROPN
admet-854	632	6	,	,	PUNCT
admet-854	632	7	m.	m.	PROPN
admet-854	632	8	rosselin	rosselin	PROPN
admet-854	632	9	,	,	PUNCT
admet-854	632	10	c.	c.	PROPN
admet-854	632	11	grundström	grundström	PROPN
admet-854	632	12	,	,	PUNCT
admet-854	632	13	c.	c.	PROPN
admet-854	632	14	hedberg	hedberg	PROPN
admet-854	632	15	,	,	PUNCT
admet-854	632	16	u.h	u.h	PROPN
admet-854	632	17	.	.	PROPN
admet-854	632	18	sauer	sauer	PROPN
admet-854	632	19	,	,	PUNCT
admet-854	632	20	m.	m.	NOUN
admet-854	632	21	wolf	wolf	NOUN
admet-854	632	22	-	-	PUNCT
admet-854	632	23	watz	watz	NOUN
admet-854	632	24	.	.	PUNCT
admet-854	633	1	molecular	molecular	ADJ
admet-854	633	2	mechanism	mechanism	NOUN
admet-854	633	3	of	of	ADP
admet-854	633	4	atp	atp	PROPN
admet-854	633	5	versus	versus	ADP
admet-854	633	6	gtp	gtp	PROPN
admet-854	633	7	selectivity	selectivity	NOUN
admet-854	633	8	of	of	ADP
admet-854	633	9	adenylate	adenylate	ADJ
admet-854	633	10	kinase	kinase	NOUN
admet-854	633	11	.	.	PUNCT
admet-854	634	1	proc	proc	PROPN
admet-854	634	2	.	.	PUNCT
admet-854	635	1	natl	natl	PROPN
admet-854	635	2	.	.	PUNCT
admet-854	636	1	acad	acad	PROPN
admet-854	636	2	.	.	PUNCT
admet-854	637	1	sci	sci	PROPN
admet-854	637	2	.	.	PUNCT
admet-854	637	3	u.s.a	u.s.a	PROPN
admet-854	637	4	.	.	PROPN
admet-854	637	5	115	115	NUM
admet-854	637	6	(	(	PUNCT
admet-854	637	7	2018	2018	NUM
admet-854	637	8	)	)	PUNCT
admet-854	637	9	3012	3012	NUM
admet-854	637	10	-	-	SYM
admet-854	637	11	3017	3017	NUM
admet-854	637	12	.	.	PUNCT
admet-854	638	1	[	[	X
admet-854	638	2	58	58	NUM
admet-854	638	3	]	]	PUNCT
admet-854	638	4	m.	m.	PROPN
admet-854	638	5	yamada	yamada	PROPN
admet-854	638	6	,	,	PUNCT
admet-854	638	7	m.	m.	NOUN
admet-854	638	8	sugahara	sugahara	PROPN
admet-854	638	9	,	,	PUNCT
admet-854	638	10	y.	y.	PROPN
admet-854	638	11	hishitani	hishitani	PROPN
admet-854	638	12	,	,	PUNCT
admet-854	638	13	m.	m.	PROPN
admet-854	638	14	nobumoto	nobumoto	PROPN
admet-854	638	15	,	,	PUNCT
admet-854	638	16	a.	a.	NOUN
admet-854	638	17	nakazawa	nakazawa	PROPN
admet-854	638	18	.	.	PUNCT
admet-854	639	1	isolation	isolation	NOUN
admet-854	639	2	and	and	CCONJ
admet-854	639	3	characterization	characterization	NOUN
admet-854	639	4	of	of	ADP
admet-854	639	5	mutated	mutate	VERB
admet-854	639	6	mitochondrial	mitochondrial	ADJ
admet-854	639	7	gtp	gtp	NOUN
admet-854	639	8	:	:	PUNCT
admet-854	639	9	amp	amp	NOUN
admet-854	639	10	phosphotransferase	phosphotransferase	NOUN
admet-854	639	11	.	.	PUNCT
admet-854	640	1	j.	j.	PROPN
admet-854	640	2	mol	mol	PROPN
admet-854	640	3	.	.	PUNCT
admet-854	641	1	biol	biol	PROPN
admet-854	641	2	.	.	PUNCT
admet-854	642	1	280	280	NUM
admet-854	642	2	(	(	PUNCT
admet-854	642	3	1998	1998	NUM
admet-854	642	4	)	)	PUNCT
admet-854	642	5	551	551	NUM
admet-854	642	6	-	-	SYM
admet-854	642	7	558	558	NUM
admet-854	642	8	.	.	PUNCT
admet-854	643	1	[	[	X
admet-854	643	2	59	59	NUM
admet-854	643	3	]	]	PUNCT
admet-854	643	4	c.	c.	NOUN
admet-854	643	5	panayiotou	panayiotou	NOUN
admet-854	643	6	,	,	PUNCT
admet-854	643	7	n.	n.	PROPN
admet-854	643	8	solaroli	solaroli	PROPN
admet-854	643	9	,	,	PUNCT
admet-854	643	10	m.	m.	NOUN
admet-854	643	11	johansson	johansson	PROPN
admet-854	643	12	,	,	PUNCT
admet-854	643	13	a.	a.	PROPN
admet-854	643	14	karlsson	karlsson	PROPN
admet-854	643	15	.	.	PUNCT
admet-854	644	1	evidence	evidence	NOUN
admet-854	644	2	of	of	ADP
admet-854	644	3	an	an	DET
admet-854	644	4	intact	intact	ADJ
admet-854	644	5	n	n	CCONJ
admet-854	644	6	-	-	PUNCT
admet-854	644	7	terminal	terminal	ADJ
admet-854	644	8	translocation	translocation	NOUN
admet-854	644	9	sequence	sequence	NOUN
admet-854	644	10	of	of	ADP
admet-854	644	11	human	human	ADJ
admet-854	644	12	mitochondrial	mitochondrial	ADJ
admet-854	644	13	adenylate	adenylate	ADJ
admet-854	644	14	kinase	kinase	NOUN
admet-854	644	15	4	4	NUM
admet-854	644	16	.	.	PUNCT
admet-854	644	17	int	int	NOUN
admet-854	644	18	.	.	PUNCT
admet-854	645	1	j.	j.	PROPN
admet-854	645	2	biochem	biochem	PROPN
admet-854	645	3	.	.	PUNCT
admet-854	646	1	cell	cell	NOUN
admet-854	646	2	biol	biol	PROPN
admet-854	646	3	.	.	PUNCT
admet-854	647	1	42	42	NUM
admet-854	647	2	(	(	PUNCT
admet-854	647	3	2010	2010	NUM
admet-854	647	4	)	)	PUNCT
admet-854	647	5	62	62	NUM
admet-854	647	6	-	-	SYM
admet-854	647	7	69	69	NUM
admet-854	647	8	.	.	PUNCT
admet-854	648	1	[	[	X
admet-854	648	2	60	60	NUM
admet-854	648	3	]	]	PUNCT
admet-854	648	4	c.	c.	NOUN
admet-854	648	5	panayiotou	panayiotou	NOUN
admet-854	648	6	,	,	PUNCT
admet-854	648	7	n.	n.	PROPN
admet-854	648	8	solaroli	solaroli	PROPN
admet-854	648	9	,	,	PUNCT
admet-854	648	10	a.	a.	PROPN
admet-854	648	11	karlsson	karlsson	PROPN
admet-854	648	12	.	.	PUNCT
admet-854	649	1	the	the	DET
admet-854	649	2	many	many	ADJ
admet-854	649	3	isoforms	isoform	NOUN
admet-854	649	4	of	of	ADP
admet-854	649	5	human	human	ADJ
admet-854	649	6	adenylate	adenylate	ADJ
admet-854	649	7	kinases	kinase	NOUN
admet-854	649	8	.	.	PUNCT
admet-854	650	1	int	int	NOUN
admet-854	650	2	.	.	PUNCT
admet-854	651	1	j.	j.	PROPN
admet-854	651	2	biochem	biochem	PROPN
admet-854	651	3	.	.	PUNCT
admet-854	652	1	cell	cell	NOUN
admet-854	652	2	biol	biol	PROPN
admet-854	652	3	.	.	PUNCT
admet-854	653	1	49	49	NUM
admet-854	653	2	(	(	PUNCT
admet-854	653	3	2014	2014	NUM
admet-854	653	4	)	)	PUNCT
admet-854	653	5	75	75	NUM
admet-854	653	6	-	-	SYM
admet-854	653	7	83	83	NUM
admet-854	653	8	.	.	PUNCT
admet-854	654	1	[	[	X
admet-854	654	2	61	61	NUM
admet-854	654	3	]	]	X
admet-854	654	4	d.s	d.s	PROPN
admet-854	654	5	.	.	PROPN
admet-854	654	6	andres	andres	PROPN
admet-854	654	7	,	,	PUNCT
admet-854	654	8	o.	o.	PROPN
admet-854	654	9	darbin	darbin	NOUN
admet-854	654	10	.	.	PUNCT
admet-854	655	1	complex	complex	ADJ
admet-854	655	2	dynamics	dynamic	NOUN
admet-854	655	3	in	in	ADP
admet-854	655	4	the	the	DET
admet-854	655	5	basal	basal	ADJ
admet-854	655	6	ganglia	ganglia	NOUN
admet-854	655	7	:	:	PUNCT
admet-854	655	8	health	health	NOUN
admet-854	655	9	and	and	CCONJ
admet-854	655	10	disease	disease	NOUN
admet-854	655	11	beyond	beyond	ADP
admet-854	655	12	the	the	DET
admet-854	655	13	motor	motor	NOUN
admet-854	655	14	system	system	NOUN
admet-854	655	15	.	.	PUNCT
admet-854	656	1	j	j	PROPN
admet-854	656	2	neuropsychiatry	neuropsychiatry	PROPN
admet-854	656	3	clin	clin	PROPN
admet-854	656	4	.	.	PUNCT
admet-854	657	1	neurosci	neurosci	PROPN
admet-854	657	2	.	.	PUNCT
admet-854	658	1	30	30	NUM
admet-854	658	2	(	(	PUNCT
admet-854	658	3	2018	2018	NUM
admet-854	658	4	)	)	PUNCT
admet-854	658	5	101	101	NUM
admet-854	658	6	-	-	SYM
admet-854	658	7	114	114	NUM
admet-854	658	8	.	.	PUNCT
admet-854	659	1	[	[	X
admet-854	659	2	62	62	NUM
admet-854	659	3	]	]	PUNCT
admet-854	659	4	a.m.	a.m.	NOUN
admet-854	659	5	graybiel	graybiel	NOUN
admet-854	659	6	.	.	PUNCT
admet-854	660	1	the	the	DET
admet-854	660	2	basal	basal	ADJ
admet-854	660	3	ganglia	ganglia	NOUN
admet-854	660	4	.	.	PUNCT
admet-854	661	1	curr	curr	PROPN
admet-854	661	2	.	.	PUNCT
admet-854	662	1	biol	biol	PROPN
admet-854	662	2	.	.	PUNCT
admet-854	663	1	10	10	NUM
admet-854	663	2	(	(	PUNCT
admet-854	663	3	2000	2000	NUM
admet-854	663	4	)	)	PUNCT
admet-854	663	5	r509	r509	PROPN
admet-854	663	6	-	-	SYM
admet-854	663	7	11	11	NUM
admet-854	663	8	.	.	PUNCT
admet-854	664	1	[	[	X
admet-854	664	2	63	63	NUM
admet-854	664	3	]	]	PUNCT
admet-854	664	4	h.	h.	PROPN
admet-854	664	5	newman	newman	PROPN
admet-854	664	6	,	,	PUNCT
admet-854	664	7	f.c	f.c	PROPN
admet-854	664	8	.	.	PROPN
admet-854	664	9	liu	liu	PROPN
admet-854	664	10	,	,	PUNCT
admet-854	664	11	a.m.	a.m.	NOUN
admet-854	664	12	graybiel	graybiel	NOUN
admet-854	664	13	.	.	PUNCT
admet-854	665	1	dynamic	dynamic	ADJ
admet-854	665	2	ordering	ordering	NOUN
admet-854	665	3	of	of	ADP
admet-854	665	4	early	early	ADJ
admet-854	665	5	generated	generate	VERB
admet-854	665	6	striatal	striatal	ADJ
admet-854	665	7	cells	cell	NOUN
admet-854	665	8	destined	destine	VERB
admet-854	665	9	to	to	PART
admet-854	665	10	form	form	VERB
admet-854	665	11	the	the	DET
admet-854	665	12	striosomal	striosomal	ADJ
admet-854	665	13	compartment	compartment	NOUN
admet-854	665	14	of	of	ADP
admet-854	665	15	the	the	DET
admet-854	665	16	striatum	striatum	NOUN
admet-854	665	17	.	.	PUNCT
admet-854	666	1	j.	j.	PROPN
admet-854	666	2	comp	comp	PROPN
admet-854	666	3	.	.	PUNCT
admet-854	667	1	neurol	neurol	PROPN
admet-854	667	2	.	.	PUNCT
admet-854	668	1	523	523	NUM
admet-854	668	2	(	(	PUNCT
admet-854	668	3	2015	2015	NUM
admet-854	668	4	)	)	PUNCT
admet-854	668	5	943	943	NUM
admet-854	668	6	-	-	SYM
admet-854	668	7	962	962	NUM
admet-854	668	8	.	.	PUNCT
admet-854	669	1	[	[	X
admet-854	669	2	64	64	NUM
admet-854	669	3	]	]	X
admet-854	669	4	e.m	e.m	PROPN
admet-854	669	5	.	.	PROPN
admet-854	669	6	yiu	yiu	PROPN
admet-854	669	7	,	,	PUNCT
admet-854	669	8	a.j	a.j	PROPN
admet-854	669	9	.	.	PROPN
admet-854	669	10	kornberg	kornberg	PROPN
admet-854	669	11	.	.	PUNCT
admet-854	670	1	duchenne	duchenne	VERB
admet-854	670	2	muscular	muscular	ADJ
admet-854	670	3	dystrophy	dystrophy	NOUN
admet-854	670	4	.	.	PUNCT
admet-854	671	1	j.	j.	PROPN
admet-854	671	2	paediatr	paediatr	PROPN
admet-854	671	3	.	.	PUNCT
admet-854	672	1	child	child	NOUN
admet-854	672	2	health	health	NOUN
admet-854	672	3	51	51	NUM
admet-854	672	4	(	(	PUNCT
admet-854	672	5	2015	2015	NUM
admet-854	672	6	)	)	PUNCT
admet-854	672	7	759	759	NUM
admet-854	672	8	-	-	SYM
admet-854	672	9	764	764	NUM
admet-854	672	10	.	.	PUNCT
admet-854	673	1	admet	admet	PROPN
admet-854	673	2	&	&	CCONJ
admet-854	673	3	dmpk	dmpk	PROPN
admet-854	673	4	8(2	8(2	NUM
admet-854	673	5	)	)	PUNCT
admet-854	673	6	(	(	PUNCT
admet-854	673	7	2020	2020	NUM
admet-854	673	8	)	)	PUNCT
admet-854	673	9	149	149	NUM
admet-854	673	10	-	-	SYM
admet-854	673	11	175	175	NUM
admet-854	673	12	amantadine	amantadine	NOUN
admet-854	673	13	binding	bind	VERB
admet-854	673	14	to	to	ADP
admet-854	673	15	the	the	DET
admet-854	673	16	enzymes	enzyme	NOUN
admet-854	673	17	regulated	regulate	VERB
admet-854	673	18	in	in	ADP
admet-854	673	19	parkinson	parkinson	NOUN
admet-854	673	20	’s	’s	PART
admet-854	673	21	disease	disease	NOUN
admet-854	673	22	doi	doi	PROPN
admet-854	673	23	:	:	PUNCT
admet-854	673	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	673	25	173	173	NUM
admet-854	674	1	[	[	X
admet-854	674	2	65	65	NUM
admet-854	674	3	]	]	X
admet-854	674	4	b.	b.	PROPN
admet-854	674	5	sunitha	sunitha	PROPN
admet-854	674	6	,	,	PUNCT
admet-854	674	7	m.	m.	PROPN
admet-854	674	8	kumar	kumar	PROPN
admet-854	674	9	,	,	PUNCT
admet-854	674	10	n.	n.	PROPN
admet-854	674	11	gowthami	gowthami	NOUN
admet-854	674	12	,	,	PUNCT
admet-854	674	13	s.	s.	PROPN
admet-854	674	14	unni	unni	PROPN
admet-854	674	15	,	,	PUNCT
admet-854	674	16	n.	n.	PROPN
admet-854	674	17	gayathri	gayathri	PROPN
admet-854	674	18	,	,	PUNCT
admet-854	674	19	t.s	t.s	PROPN
admet-854	674	20	.	.	PROPN
admet-854	674	21	keshava	keshava	PROPN
admet-854	674	22	prasad	prasad	PROPN
admet-854	674	23	,	,	PUNCT
admet-854	674	24	a.	a.	PROPN
admet-854	674	25	nalini	nalini	PROPN
admet-854	674	26	,	,	PUNCT
admet-854	674	27	k.	k.	PROPN
admet-854	674	28	polavarapu	polavarapu	PROPN
admet-854	674	29	,	,	PUNCT
admet-854	674	30	s.	s.	PROPN
admet-854	674	31	vengalil	vengalil	PROPN
admet-854	674	32	,	,	PUNCT
admet-854	674	33	v.	v.	ADP
admet-854	674	34	preethish	preethish	NOUN
admet-854	674	35	-	-	PUNCT
admet-854	674	36	kumar	kumar	PROPN
admet-854	674	37	,	,	PUNCT
admet-854	674	38	b.	b.	PROPN
admet-854	674	39	padmanabhan	padmanabhan	PROPN
admet-854	674	40	,	,	PUNCT
admet-854	674	41	m.m	m.m	PROPN
admet-854	674	42	.	.	PROPN
admet-854	674	43	srinivas	srinivas	PROPN
admet-854	674	44	bharath	bharath	PROPN
admet-854	674	45	.	.	PUNCT
admet-854	675	1	human	human	ADJ
admet-854	675	2	muscle	muscle	NOUN
admet-854	675	3	pathology	pathology	NOUN
admet-854	675	4	is	be	AUX
admet-854	675	5	associated	associate	VERB
admet-854	675	6	with	with	ADP
admet-854	675	7	altered	alter	VERB
admet-854	675	8	phosphoprotein	phosphoprotein	ADJ
admet-854	675	9	profile	profile	NOUN
admet-854	675	10	of	of	ADP
admet-854	675	11	mitochondrial	mitochondrial	ADJ
admet-854	675	12	proteins	protein	NOUN
admet-854	675	13	in	in	ADP
admet-854	675	14	the	the	DET
admet-854	675	15	skeletal	skeletal	ADJ
admet-854	675	16	muscle	muscle	NOUN
admet-854	675	17	.	.	PUNCT
admet-854	676	1	j.	j.	PROPN
admet-854	676	2	proteomics	proteomics	PROPN
admet-854	676	3	211	211	NUM
admet-854	676	4	(	(	PUNCT
admet-854	676	5	2020	2020	NUM
admet-854	676	6	)	)	PUNCT
admet-854	676	7	103556	103556	NUM
admet-854	676	8	.	.	PUNCT
admet-854	677	1	[	[	X
admet-854	677	2	66	66	NUM
admet-854	677	3	]	]	X
admet-854	677	4	y.	y.	PROPN
admet-854	677	5	gao	gao	PROPN
admet-854	677	6	,	,	PUNCT
admet-854	677	7	x.	x.	PROPN
admet-854	677	8	zhou	zhou	PROPN
admet-854	677	9	,	,	PUNCT
admet-854	677	10	h.	h.	PROPN
admet-854	677	11	wang	wang	PROPN
admet-854	677	12	,	,	PUNCT
admet-854	677	13	r.	r.	PROPN
admet-854	677	14	liu	liu	PROPN
admet-854	677	15	,	,	PUNCT
admet-854	677	16	q.	q.	PROPN
admet-854	677	17	ye	ye	PROPN
admet-854	677	18	,	,	PUNCT
admet-854	677	19	q.	q.	PROPN
admet-854	677	20	zhao	zhao	PROPN
admet-854	677	21	,	,	PUNCT
admet-854	677	22	z.	z.	PROPN
admet-854	677	23	ming	ming	PROPN
admet-854	677	24	,	,	PUNCT
admet-854	677	25	h.	h.	PROPN
admet-854	677	26	dong	dong	PROPN
admet-854	677	27	.	.	PUNCT
admet-854	678	1	immunization	immunization	NOUN
admet-854	678	2	with	with	ADP
admet-854	678	3	recombinant	recombinant	ADJ
admet-854	678	4	schistosome	schistosome	NOUN
admet-854	678	5	adenylate	adenylate	ADJ
admet-854	678	6	kinase	kinase	NOUN
admet-854	678	7	1	1	NUM
admet-854	678	8	partially	partially	ADV
admet-854	678	9	protects	protect	VERB
admet-854	678	10	mice	mouse	NOUN
admet-854	678	11	against	against	ADP
admet-854	678	12	schistosoma	schistosoma	ADJ
admet-854	678	13	japonicum	japonicum	NOUN
admet-854	678	14	infection	infection	NOUN
admet-854	678	15	.	.	PUNCT
admet-854	679	1	parasitol	parasitol	NOUN
admet-854	679	2	.	.	PUNCT
admet-854	680	1	res	re	NOUN
admet-854	680	2	.	.	PROPN
admet-854	681	1	116	116	NUM
admet-854	681	2	(	(	PUNCT
admet-854	681	3	2017	2017	NUM
admet-854	681	4	)	)	PUNCT
admet-854	681	5	1665	1665	NUM
admet-854	681	6	-	-	SYM
admet-854	681	7	1674	1674	NUM
admet-854	681	8	.	.	PUNCT
admet-854	682	1	[	[	X
admet-854	682	2	67	67	NUM
admet-854	682	3	]	]	X
admet-854	682	4	p.	p.	NOUN
admet-854	682	5	dzeja	dzeja	PROPN
admet-854	682	6	,	,	PUNCT
admet-854	682	7	a.	a.	NOUN
admet-854	682	8	terzic	terzic	NOUN
admet-854	682	9	.	.	PUNCT
admet-854	683	1	adenylate	adenylate	ADJ
admet-854	683	2	kinase	kinase	NOUN
admet-854	683	3	and	and	CCONJ
admet-854	683	4	amp	amp	PROPN
admet-854	683	5	signaling	signal	VERB
admet-854	683	6	networks	network	NOUN
admet-854	683	7	:	:	PUNCT
admet-854	683	8	metabolic	metabolic	NOUN
admet-854	683	9	monitoring	monitoring	NOUN
admet-854	683	10	,	,	PUNCT
admet-854	683	11	signal	signal	ADJ
admet-854	683	12	communication	communication	NOUN
admet-854	683	13	and	and	CCONJ
admet-854	683	14	body	body	NOUN
admet-854	683	15	energy	energy	NOUN
admet-854	683	16	sensing	sensing	NOUN
admet-854	683	17	.	.	PUNCT
admet-854	684	1	int	int	NOUN
admet-854	684	2	.	.	PUNCT
admet-854	685	1	j.	j.	PROPN
admet-854	685	2	mol	mol	PROPN
admet-854	685	3	.	.	PUNCT
admet-854	686	1	sci	sci	PROPN
admet-854	686	2	.	.	PROPN
admet-854	687	1	10	10	NUM
admet-854	687	2	(	(	PUNCT
admet-854	687	3	2009	2009	NUM
admet-854	687	4	)	)	PUNCT
admet-854	687	5	1729	1729	NUM
admet-854	687	6	-	-	SYM
admet-854	687	7	1772	1772	NUM
admet-854	687	8	.	.	PUNCT
admet-854	688	1	©	©	PROPN
admet-854	688	2	2020	2020	NUM
admet-854	688	3	by	by	ADP
admet-854	688	4	the	the	DET
admet-854	688	5	authors	author	NOUN
admet-854	688	6	;	;	PUNCT
admet-854	688	7	licensee	licensee	PROPN
admet-854	688	8	iapc	iapc	PROPN
admet-854	688	9	,	,	PUNCT
admet-854	688	10	zagreb	zagreb	PROPN
admet-854	688	11	,	,	PUNCT
admet-854	688	12	croatia	croatia	PROPN
admet-854	688	13	.	.	PUNCT
admet-854	689	1	this	this	DET
admet-854	689	2	article	article	NOUN
admet-854	689	3	is	be	AUX
admet-854	689	4	an	an	DET
admet-854	689	5	open	open	ADJ
admet-854	689	6	-	-	PUNCT
admet-854	689	7	access	access	NOUN
admet-854	689	8	article	article	NOUN
admet-854	689	9	distributed	distribute	VERB
admet-854	689	10	under	under	ADP
admet-854	689	11	the	the	DET
admet-854	689	12	terms	term	NOUN
admet-854	689	13	and	and	CCONJ
admet-854	689	14	conditions	condition	NOUN
admet-854	689	15	of	of	ADP
admet-854	689	16	the	the	DET
admet-854	689	17	creative	creative	ADJ
admet-854	689	18	commons	common	NOUN
admet-854	689	19	attribution	attribution	NOUN
admet-854	689	20	license	license	NOUN
admet-854	689	21	(	(	PUNCT
admet-854	689	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-854	689	23	)	)	PUNCT
admet-854	689	24	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	PROPN
admet-854	689	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-854	689	26	mihaela	mihaela	PROPN
admet-854	689	27	ileana	ileana	PROPN
admet-854	689	28	ionescu	ionescu	PROPN
admet-854	689	29	admet	admet	PROPN
admet-854	689	30	&	&	CCONJ
admet-854	689	31	dmpk	dmpk	PROPN
admet-854	689	32	8(2	8(2	NUM
admet-854	689	33	)	)	PUNCT
admet-854	689	34	(	(	PUNCT
admet-854	689	35	2020	2020	NUM
admet-854	689	36	)	)	PUNCT
admet-854	689	37	149	149	NUM
admet-854	689	38	-	-	SYM
admet-854	689	39	175	175	NUM
admet-854	689	40	174	174	NUM
admet-854	689	41	table	table	NOUN
admet-854	689	42	s1	s1	NOUN
admet-854	689	43	.	.	PUNCT
admet-854	690	1	the	the	DET
admet-854	690	2	characteristics	characteristic	NOUN
admet-854	690	3	of	of	ADP
admet-854	690	4	the	the	DET
admet-854	690	5	aks	ak	NOUN
admet-854	690	6	included	include	VERB
admet-854	690	7	in	in	ADP
admet-854	690	8	the	the	DET
admet-854	690	9	study	study	NOUN
admet-854	690	10	.	.	PUNCT
admet-854	691	1	pdb	pdb	PROPN
admet-854	692	1	i	i	PROPN
admet-854	692	2	d	d	PROPN
admet-854	692	3	organism	organism	NOUN
admet-854	692	4	residues	residue	NOUN
admet-854	692	5	co	co	VERB
admet-854	692	6	-	-	VERB
admet-854	692	7	crystallized	crystallize	VERB
admet-854	692	8	with	with	ADP
admet-854	692	9	substrate	substrate	NOUN
admet-854	692	10	or	or	CCONJ
admet-854	692	11	analog	analog	NOUN
admet-854	692	12	substrate	substrate	NOUN
admet-854	692	13	mutations	mutation	NOUN
admet-854	692	14	reference	reference	NOUN
admet-854	692	15	ak1	ak1	ADJ
admet-854	692	16	2c95	2c95	ADJ
admet-854	692	17	homo	homo	NOUN
admet-854	692	18	sapiens	sapien	VERB
admet-854	692	19	194	194	NUM
admet-854	692	20	b4p	b4p	NOUN
admet-854	692	21	1	1	NUM
admet-854	692	22	;	;	PUNCT
admet-854	692	23	malonate	malonate	VERB
admet-854	692	24	ion	ion	NOUN
admet-854	692	25	no	no	PRON
admet-854	692	26	unpublished	unpublished	ADJ
admet-854	692	27	ak1	ak1	PROPN
admet-854	693	1	1z83	1z83	NUM
admet-854	694	1	homo	homo	NOUN
admet-854	694	2	sapiens	sapien	VERB
admet-854	694	3	196	196	NUM
admet-854	694	4	ap5a	ap5a	NOUN
admet-854	694	5	2	2	NUM
admet-854	694	6	;	;	PUNCT
admet-854	694	7	so4	so4	PROPN
admet-854	694	8	2	2	NUM
admet-854	694	9	;	;	PUNCT
admet-854	694	10	zn	zn	PROPN
admet-854	694	11	2	2	NUM
admet-854	694	12	+	+	CCONJ
admet-854	694	13	no	no	PRON
admet-854	694	14	unpublished	unpublished	ADJ
admet-854	694	15	ak1	ak1	NOUN
admet-854	694	16	5xz2	5xz2	NUM
admet-854	694	17	danio	danio	PROPN
admet-854	694	18	rerio	rerio	PROPN
admet-854	694	19	196	196	NUM
admet-854	694	20	ap5a	ap5a	PROPN
admet-854	694	21	;	;	PUNCT
admet-854	694	22	so4	so4	PROPN
admet-854	694	23	2	2	NUM
admet-854	695	1	no	no	PRON
admet-854	696	1	[	[	X
admet-854	696	2	32	32	NUM
admet-854	696	3	]	]	PUNCT
admet-854	696	4	ak2	ak2	NOUN
admet-854	696	5	2c9y	2c9y	PROPN
admet-854	696	6	homo	homo	NOUN
admet-854	696	7	sapiens	sapien	VERB
admet-854	696	8	242	242	NUM
admet-854	696	9	b4p	b4p	NOUN
admet-854	696	10	;	;	PUNCT
admet-854	696	11	1,2	1,2	NUM
admet-854	696	12	-	-	NOUN
admet-854	696	13	ethandiol	ethandiol	NOUN
admet-854	696	14	no	no	DET
admet-854	696	15	unpublished	unpublished	ADJ
admet-854	696	16	ak4	ak4	NOUN
admet-854	696	17	2ar7	2ar7	NUM
admet-854	696	18	homo	homo	NOUN
admet-854	696	19	sapiens	sapien	VERB
admet-854	696	20	246	246	NUM
admet-854	696	21	no	no	INTJ
admet-854	696	22	no	no	ADV
admet-854	696	23	unpublished	unpublished	ADJ
admet-854	696	24	ak4	ak4	NOUN
admet-854	696	25	2bbw	2bbw	NUM
admet-854	696	26	homo	homo	NOUN
admet-854	696	27	sapiens	sapien	VERB
admet-854	696	28	246	246	NUM
admet-854	696	29	gp5	gp5	NOUN
admet-854	696	30	3	3	NUM
admet-854	696	31	no	no	PRON
admet-854	696	32	unpublished	unpublished	ADJ
admet-854	696	33	ak5	ak5	NOUN
admet-854	696	34	2bwj	2bwj	NUM
admet-854	696	35	homo	homo	NOUN
admet-854	696	36	sapiens	sapien	VERB
admet-854	696	37	199	199	NUM
admet-854	696	38	amp	amp	NOUN
admet-854	696	39	r135	r135	NOUN
admet-854	696	40	m	m	NOUN
admet-854	696	41	unpublished	unpublished	ADJ
admet-854	696	42	3hpq	3hpq	PROPN
admet-854	696	43	e.coli	e.coli	NOUN
admet-854	696	44	214	214	NUM
admet-854	696	45	ap5a	ap5a	NOUN
admet-854	697	1	no	no	PRON
admet-854	698	1	[	[	X
admet-854	698	2	33	33	NUM
admet-854	698	3	]	]	PUNCT
admet-854	698	4	1zip	1zip	NUM
admet-854	698	5	b.	b.	PROPN
admet-854	698	6	stearothermophilus	stearothermophilus	PROPN
admet-854	698	7	ap5a	ap5a	PROPN
admet-854	698	8	;	;	PUNCT
admet-854	698	9	mn	mn	PROPN
admet-854	698	10	2	2	NUM
admet-854	698	11	+	+	CCONJ
admet-854	698	12	;	;	PUNCT
admet-854	698	13	zn	zn	PROPN
admet-854	698	14	2	2	NUM
admet-854	698	15	+	+	NUM
admet-854	699	1	no	no	PRON
admet-854	700	1	[	[	X
admet-854	700	2	34	34	NUM
admet-854	700	3	]	]	SYM
admet-854	700	4	1	1	NUM
admet-854	700	5	p1	p1	NOUN
admet-854	700	6	,	,	PUNCT
admet-854	700	7	p4	p4	ADJ
admet-854	700	8	-	-	PUNCT
admet-854	700	9	di(adenosine)tetraphosphate	di(adenosine)tetraphosphate	NOUN
admet-854	700	10	,	,	PUNCT
admet-854	700	11	2	2	NUM
admet-854	700	12	bis(adenosine)-5’-pentaphosphate	bis(adenosine)-5’-pentaphosphate	NOUN
admet-854	700	13	,	,	PUNCT
admet-854	700	14	3	3	NUM
admet-854	700	15	diguanosine	diguanosine	NOUN
admet-854	700	16	-	-	PUNCT
admet-854	700	17	pentaphosphate	pentaphosphate	NOUN
admet-854	700	18	.	.	PUNCT
admet-854	700	19	table	table	NOUN
admet-854	700	20	s2	s2	PROPN
admet-854	700	21	.	.	PUNCT
admet-854	701	1	the	the	DET
admet-854	701	2	characteristics	characteristic	NOUN
admet-854	701	3	of	of	ADP
admet-854	701	4	the	the	DET
admet-854	701	5	aprts	aprt	NOUN
admet-854	701	6	included	include	VERB
admet-854	701	7	in	in	ADP
admet-854	701	8	the	the	DET
admet-854	701	9	study	study	NOUN
admet-854	701	10	.	.	PUNCT
admet-854	702	1	pdb	pdb	PROPN
admet-854	703	1	i	i	PROPN
admet-854	703	2	d	d	PROPN
admet-854	703	3	organism	organism	NOUN
admet-854	703	4	residues	residue	NOUN
admet-854	703	5	co	co	VERB
admet-854	703	6	-	-	VERB
admet-854	703	7	crystallized	crystallize	VERB
admet-854	703	8	with	with	ADP
admet-854	703	9	substrate	substrate	NOUN
admet-854	703	10	or	or	CCONJ
admet-854	703	11	analog	analog	NOUN
admet-854	703	12	substrate	substrate	NOUN
admet-854	703	13	mutations	mutation	NOUN
admet-854	703	14	reference	reference	NOUN
admet-854	703	15	1ore	1ore	NUM
admet-854	703	16	homo	homo	NOUN
admet-854	703	17	sapiens	sapien	VERB
admet-854	703	18	180	180	NUM
admet-854	703	19	amp	amp	NOUN
admet-854	703	20	1	1	NUM
admet-854	703	21	;	;	PUNCT
admet-854	703	22	cl	cl	INTJ
admet-854	703	23	no	no	PRON
admet-854	704	1	[	[	NOUN
admet-854	704	2	35	35	NUM
admet-854	704	3	]	]	SYM
admet-854	704	4	1zn7	1zn7	NUM
admet-854	704	5	homo	homo	NOUN
admet-854	704	6	sapiens	sapien	VERB
admet-854	704	7	180	180	NUM
admet-854	704	8	prp	prp	NOUN
admet-854	704	9	2	2	NUM
admet-854	704	10	;	;	PUNCT
admet-854	704	11	hsx	hsx	NOUN
admet-854	704	12	3	3	NUM
admet-854	704	13	,	,	PUNCT
admet-854	704	14	ade	ade	PROPN
admet-854	704	15	4	4	NUM
admet-854	704	16	;	;	PUNCT
admet-854	704	17	po4	po4	PROPN
admet-854	704	18	;	;	PUNCT
admet-854	704	19	mg2	mg2	PROPN
admet-854	705	1	+	+	CCONJ
admet-854	706	1	no	no	DET
admet-854	706	2	[	[	NOUN
admet-854	706	3	36	36	NUM
admet-854	706	4	]	]	SYM
admet-854	706	5	1zn8	1zn8	NUM
admet-854	706	6	homo	homo	NOUN
admet-854	706	7	sapiens	sapien	VERB
admet-854	706	8	180	180	NUM
admet-854	706	9	amp	amp	NOUN
admet-854	706	10	;	;	PUNCT
admet-854	706	11	cl	cl	INTJ
admet-854	706	12	no	no	PRON
admet-854	707	1	[	[	NOUN
admet-854	707	2	36	36	NUM
admet-854	707	3	]	]	SYM
admet-854	707	4	1zn9	1zn9	NUM
admet-854	707	5	homo	homo	NOUN
admet-854	707	6	sapiens	sapien	VERB
admet-854	707	7	180	180	NUM
admet-854	707	8	amp	amp	NOUN
admet-854	707	9	no	no	NOUN
admet-854	708	1	[	[	NOUN
admet-854	708	2	36	36	NUM
admet-854	708	3	]	]	PUNCT
admet-854	708	4	4x44	4x44	NOUN
admet-854	708	5	homo	homo	NOUN
admet-854	708	6	sapiens	sapien	VERB
admet-854	708	7	180	180	NUM
admet-854	708	8	amp	amp	NOUN
admet-854	708	9	,	,	PUNCT
admet-854	708	10	so4-	so4-	NOUN
admet-854	708	11	;	;	PUNCT
admet-854	708	12	gol	gol	PROPN
admet-854	708	13	5	5	NUM
admet-854	708	14	r89q	r89q	NOUN
admet-854	708	15	unpublished	unpublished	ADJ
admet-854	708	16	6fci	6fci	PROPN
admet-854	708	17	homo	homo	NOUN
admet-854	708	18	sapiens	sapien	VERB
admet-854	708	19	180	180	NUM
admet-854	708	20	prp	prp	NOUN
admet-854	708	21	;	;	PUNCT
admet-854	708	22	ade	ade	PROPN
admet-854	708	23	;	;	PUNCT
admet-854	708	24	mg2	mg2	PROPN
admet-854	709	1	+	+	CCONJ
admet-854	709	2	no	no	DET
admet-854	709	3	[	[	X
admet-854	709	4	37	37	NUM
admet-854	709	5	]	]	SYM
admet-854	709	6	1	1	NUM
admet-854	709	7	amp	amp	NOUN
admet-854	709	8	–	–	PUNCT
admet-854	709	9	adenosine	adenosine	NOUN
admet-854	709	10	monophosphate	monophosphate	NOUN
admet-854	709	11	;	;	PUNCT
admet-854	709	12	2	2	NUM
admet-854	709	13	alpha	alpha	NOUN
admet-854	709	14	-	-	PUNCT
admet-854	709	15	phosphoribosylpyrpphosphoric	phosphoribosylpyrpphosphoric	ADJ
admet-854	709	16	acid	acid	NOUN
admet-854	709	17	;	;	PUNCT
admet-854	709	18	3	3	NUM
admet-854	709	19	5	5	NUM
admet-854	709	20	-	-	PUNCT
admet-854	709	21	o	o	NOUN
admet-854	709	22	-	-	NOUN
admet-854	709	23	phosphono	phosphono	ADJ
admet-854	709	24	-	-	PUNCT
admet-854	709	25	alpha	alpha	NOUN
admet-854	709	26	-	-	PUNCT
admet-854	709	27	d	d	NOUN
admet-854	709	28	-	-	PUNCT
admet-854	709	29	ribofuranose	ribofuranose	VERB
admet-854	709	30	;	;	PUNCT
admet-854	709	31	4	4	NUM
admet-854	709	32	adenine	adenine	NOUN
admet-854	709	33	;	;	PUNCT
admet-854	709	34	5	5	NUM
admet-854	709	35	glycerol	glycerol	NOUN
admet-854	709	36	table	table	NOUN
admet-854	709	37	s3	s3	PROPN
admet-854	709	38	.	.	PUNCT
admet-854	710	1	the	the	DET
admet-854	710	2	characteristics	characteristic	NOUN
admet-854	710	3	of	of	ADP
admet-854	710	4	the	the	DET
admet-854	710	5	nt5es	nt5es	NUM
admet-854	710	6	included	include	VERB
admet-854	710	7	in	in	ADP
admet-854	710	8	the	the	DET
admet-854	710	9	study	study	NOUN
admet-854	710	10	.	.	PUNCT
admet-854	711	1	pdb	pdb	PROPN
admet-854	712	1	i	i	PROPN
admet-854	712	2	d	d	PROPN
admet-854	712	3	organism	organism	NOUN
admet-854	712	4	residues	residue	NOUN
admet-854	712	5	co	co	VERB
admet-854	712	6	-	-	VERB
admet-854	712	7	crystallized	crystallize	VERB
admet-854	712	8	with	with	ADP
admet-854	712	9	substrate	substrate	NOUN
admet-854	712	10	or	or	CCONJ
admet-854	712	11	analog	analog	NOUN
admet-854	712	12	substrate	substrate	NOUN
admet-854	712	13	mutations	mutation	NOUN
admet-854	712	14	reference	reference	NOUN
admet-854	712	15	4h2i	4h2i	NOUN
admet-854	712	16	homo	homo	NOUN
admet-854	712	17	sapiens	sapien	VERB
admet-854	712	18	532	532	NUM
admet-854	712	19	a12	a12	NOUN
admet-854	712	20	1	1	NUM
admet-854	712	21	;	;	PUNCT
admet-854	712	22	zn2	zn2	PROPN
admet-854	712	23	+	+	NOUN
admet-854	712	24	;	;	PUNCT
admet-854	712	25	ca2	ca2	PROPN
admet-854	712	26	+	+	PROPN
admet-854	712	27	;	;	PUNCT
admet-854	712	28	cl	cl	INTJ
admet-854	712	29	no	no	PRON
admet-854	713	1	[	[	X
admet-854	713	2	38	38	NUM
admet-854	713	3	]	]	SYM
admet-854	713	4	4h2	4h2	NOUN
admet-854	713	5	g	g	PROPN
admet-854	713	6	homo	homo	NOUN
admet-854	713	7	sapiens	sapien	VERB
admet-854	713	8	546	546	NUM
admet-854	713	9	and	and	CCONJ
admet-854	713	10	2	2	NUM
admet-854	713	11	,	,	PUNCT
admet-854	713	12	zn2	zn2	PROPN
admet-854	714	1	+	+	NOUN
admet-854	714	2	;	;	PUNCT
admet-854	715	1	ca2	ca2	PROPN
admet-854	715	2	+	+	PROPN
admet-854	715	3	;	;	PUNCT
admet-854	715	4	cl	cl	NOUN
admet-854	715	5	seven	seven	NUM
admet-854	715	6	[	[	X
admet-854	715	7	38	38	NUM
admet-854	715	8	]	]	PUNCT
admet-854	715	9	4h2f	4h2f	PRON
admet-854	715	10	homo	homo	NOUN
admet-854	715	11	sapiens	sapien	VERB
admet-854	715	12	546	546	NUM
admet-854	715	13	and	and	CCONJ
admet-854	715	14	2	2	NUM
admet-854	715	15	,	,	PUNCT
admet-854	715	16	zn2	zn2	PROPN
admet-854	716	1	+	+	NOUN
admet-854	716	2	;	;	PUNCT
admet-854	716	3	ca2	ca2	PROPN
admet-854	716	4	+	+	PROPN
admet-854	716	5	;	;	PUNCT
admet-854	716	6	cl	cl	NOUN
admet-854	716	7	seven	seven	NUM
admet-854	716	8	[	[	X
admet-854	716	9	38	38	NUM
admet-854	716	10	]	]	PUNCT
admet-854	716	11	4h1s	4h1s	PRON
admet-854	716	12	homo	homo	NOUN
admet-854	716	13	sapiens	sapien	VERB
admet-854	716	14	530	530	NUM
admet-854	716	15	nag	nag	ADP
admet-854	716	16	3	3	NUM
admet-854	716	17	;	;	PUNCT
admet-854	717	1	po4	po4	PROPN
admet-854	717	2	;	;	PUNCT
admet-854	717	3	zn2	zn2	X
admet-854	717	4	+	+	CCONJ
admet-854	718	1	no	no	DET
admet-854	718	2	[	[	NOUN
admet-854	718	3	39	39	NUM
admet-854	718	4	]	]	SYM
admet-854	718	5	1	1	NUM
admet-854	718	6	phosphomethylphosphonic	phosphomethylphosphonic	ADJ
admet-854	718	7	acid	acid	NOUN
admet-854	718	8	adenosyl	adenosyl	NOUN
admet-854	718	9	ester	ester	NOUN
admet-854	718	10	;	;	PUNCT
admet-854	718	11	2	2	NUM
admet-854	718	12	adenosine	adenosine	NOUN
admet-854	718	13	;	;	PUNCT
admet-854	718	14	3	3	NUM
admet-854	718	15	n	n	CCONJ
admet-854	718	16	-	-	PUNCT
admet-854	718	17	actetyl	actetyl	NOUN
admet-854	718	18	-	-	PUNCT
admet-854	718	19	d	d	NOUN
admet-854	718	20	-	-	PUNCT
admet-854	718	21	glucosamine	glucosamine	NOUN
admet-854	718	22	admet	admet	NOUN
admet-854	718	23	&	&	CCONJ
admet-854	718	24	dmpk	dmpk	PROPN
admet-854	718	25	8(2	8(2	NUM
admet-854	718	26	)	)	PUNCT
admet-854	718	27	(	(	PUNCT
admet-854	718	28	2020	2020	NUM
admet-854	718	29	)	)	PUNCT
admet-854	718	30	149	149	NUM
admet-854	718	31	-	-	SYM
admet-854	718	32	175	175	NUM
admet-854	718	33	amantadine	amantadine	NOUN
admet-854	718	34	binding	bind	VERB
admet-854	718	35	to	to	ADP
admet-854	718	36	the	the	DET
admet-854	718	37	enzymes	enzyme	NOUN
admet-854	718	38	regulated	regulate	VERB
admet-854	718	39	in	in	ADP
admet-854	718	40	parkinson	parkinson	NOUN
admet-854	718	41	’s	’s	PART
admet-854	718	42	disease	disease	NOUN
admet-854	718	43	doi	doi	PROPN
admet-854	718	44	:	:	PUNCT
admet-854	718	45	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	X
admet-854	718	46	175	175	NUM
admet-854	718	47	table	table	NOUN
admet-854	718	48	s4	s4	NOUN
admet-854	718	49	.	.	PUNCT
admet-854	719	1	the	the	DET
admet-854	719	2	characteristics	characteristic	NOUN
admet-854	719	3	of	of	ADP
admet-854	719	4	the	the	DET
admet-854	719	5	ndk3s	ndk3s	NOUN
admet-854	719	6	included	include	VERB
admet-854	719	7	in	in	ADP
admet-854	719	8	the	the	DET
admet-854	719	9	study	study	NOUN
admet-854	719	10	.	.	PUNCT
admet-854	720	1	pdb	pdb	PROPN
admet-854	721	1	i	i	PROPN
admet-854	721	2	d	d	PROPN
admet-854	721	3	organism	organism	NOUN
admet-854	721	4	residues	residue	NOUN
admet-854	721	5	co	co	VERB
admet-854	721	6	-	-	VERB
admet-854	721	7	crystallized	crystallize	VERB
admet-854	721	8	with	with	ADP
admet-854	721	9	substrate	substrate	NOUN
admet-854	721	10	or	or	CCONJ
admet-854	721	11	analog	analog	NOUN
admet-854	721	12	substrate	substrate	NOUN
admet-854	721	13	mutations	mutation	NOUN
admet-854	721	14	reference	reference	NOUN
admet-854	721	15	1zs6	1zs6	NUM
admet-854	721	16	homo	homo	NOUN
admet-854	721	17	sapiens	sapien	VERB
admet-854	721	18	169	169	NUM
admet-854	721	19	adp	adp	PROPN
admet-854	721	20	1	1	NUM
admet-854	721	21	no	no	PRON
admet-854	721	22	unpublished	unpublished	ADJ
admet-854	721	23	2hvd	2hvd	NUM
admet-854	721	24	homo	homo	NOUN
admet-854	721	25	sapiens	sapien	VERB
admet-854	721	26	152	152	NUM
admet-854	721	27	adp	adp	PROPN
admet-854	722	1	no	no	INTJ
admet-854	723	1	[	[	X
admet-854	723	2	40	40	NUM
admet-854	723	3	]	]	SYM
admet-854	723	4	2hve	2hve	NUM
admet-854	723	5	homo	homo	NOUN
admet-854	723	6	sapiens	sapien	VERB
admet-854	723	7	152	152	NUM
admet-854	723	8	adp	adp	PROPN
admet-854	723	9	s120	s120	PROPN
admet-854	723	10	g	g	PROPN
admet-854	724	1	[	[	X
admet-854	724	2	40	40	NUM
admet-854	724	3	]	]	PUNCT
admet-854	724	4	1jxv	1jxv	NUM
admet-854	724	5	homo	homo	NOUN
admet-854	724	6	sapiens	sapien	VERB
admet-854	725	1	152	152	NUM
admet-854	725	2	no	no	INTJ
admet-854	725	3	no	no	INTJ
admet-854	726	1	[	[	X
admet-854	726	2	41	41	NUM
admet-854	726	3	]	]	X
admet-854	726	4	3bbb	3bbb	NUM
admet-854	726	5	homo	homo	NOUN
admet-854	726	6	sapiens	sapien	VERB
admet-854	726	7	151	151	NUM
admet-854	726	8	dg	dg	NOUN
admet-854	726	9	2	2	NUM
admet-854	726	10	;	;	PUNCT
admet-854	726	11	da	da	PROPN
admet-854	726	12	3	3	NUM
admet-854	726	13	no	no	INTJ
admet-854	727	1	[	[	X
admet-854	727	2	42	42	NUM
admet-854	727	3	]	]	SYM
admet-854	727	4	1	1	NUM
admet-854	727	5	adenosine-5’-diphosphate	adenosine-5’-diphosphate	ADJ
admet-854	727	6	;	;	PUNCT
admet-854	727	7	2	2	NUM
admet-854	727	8	2’-deoxyguanosine-5’-monophosphate	2’-deoxyguanosine-5’-monophosphate	NUM
admet-854	727	9	;	;	PUNCT
admet-854	727	10	3	3	NUM
admet-854	727	11	2’-deoxyadenosine-5’-monophosphate	2’-deoxyadenosine-5’-monophosphate	NUM
admet-854	727	12	table	table	NOUN
admet-854	727	13	s5	s5	NOUN
admet-854	727	14	.	.	PUNCT
admet-854	728	1	the	the	DET
admet-854	728	2	characteristics	characteristic	NOUN
admet-854	728	3	of	of	ADP
admet-854	728	4	the	the	DET
admet-854	728	5	pnp1s	pnp1s	PROPN
admet-854	728	6	included	include	VERB
admet-854	728	7	in	in	ADP
admet-854	728	8	the	the	DET
admet-854	728	9	study	study	NOUN
admet-854	728	10	.	.	PUNCT
admet-854	729	1	pdb	pdb	PROPN
admet-854	730	1	i	i	PROPN
admet-854	730	2	d	d	PROPN
admet-854	730	3	organism	organism	NOUN
admet-854	730	4	residues	residue	NOUN
admet-854	730	5	co	co	VERB
admet-854	730	6	-	-	VERB
admet-854	730	7	crystallized	crystallize	VERB
admet-854	730	8	with	with	ADP
admet-854	730	9	substrate	substrate	NOUN
admet-854	730	10	or	or	CCONJ
admet-854	730	11	analog	analog	NOUN
admet-854	730	12	substrate	substrate	NOUN
admet-854	730	13	mutations	mutation	NOUN
admet-854	730	14	reference	reference	NOUN
admet-854	730	15	1ula	1ula	NUM
admet-854	730	16	homo	homo	NOUN
admet-854	730	17	sapiens	sapien	VERB
admet-854	730	18	289	289	NUM
admet-854	730	19	so4	so4	NOUN
admet-854	731	1	no	no	PRON
admet-854	732	1	[	[	X
admet-854	732	2	43	43	NUM
admet-854	732	3	]	]	X
admet-854	732	4	1ulb	1ulb	NUM
admet-854	732	5	homo	homo	NOUN
admet-854	732	6	sapiens	sapien	VERB
admet-854	732	7	289	289	NUM
admet-854	732	8	guanine	guanine	NOUN
admet-854	732	9	;	;	PUNCT
admet-854	732	10	so4	so4	PROPN
admet-854	732	11	no	no	PROPN
admet-854	733	1	[	[	X
admet-854	733	2	43	43	NUM
admet-854	733	3	]	]	X
admet-854	733	4	2a0w	2a0w	ADJ
admet-854	733	5	homo	homo	NOUN
admet-854	733	6	sapiens	sapien	VERB
admet-854	733	7	289	289	NUM
admet-854	733	8	dih	dih	NOUN
admet-854	733	9	1	1	NUM
admet-854	733	10	;	;	PUNCT
admet-854	733	11	so4	so4	PROPN
admet-854	733	12	h257	h257	PROPN
admet-854	733	13	g	g	PROPN
admet-854	733	14	[	[	X
admet-854	733	15	44	44	NUM
admet-854	733	16	]	]	PUNCT
admet-854	733	17	2a0x	2a0x	NUM
admet-854	733	18	homo	homo	NOUN
admet-854	733	19	sapiens	sapien	VERB
admet-854	733	20	289	289	NUM
admet-854	733	21	dih	dih	NOUN
admet-854	733	22	1	1	NUM
admet-854	733	23	;	;	PUNCT
admet-854	733	24	so4	so4	PROPN
admet-854	733	25	h257f	h257f	PROPN
admet-854	734	1	[	[	X
admet-854	734	2	44	44	NUM
admet-854	734	3	]	]	SYM
admet-854	734	4	2a0y	2a0y	NUM
admet-854	734	5	homo	homo	NOUN
admet-854	734	6	sapiens	sapien	VERB
admet-854	734	7	289	289	NUM
admet-854	734	8	dih	dih	NOUN
admet-854	734	9	1	1	NUM
admet-854	734	10	;	;	PUNCT
admet-854	734	11	so4	so4	PROPN
admet-854	734	12	h257d	h257d	PROPN
admet-854	735	1	[	[	X
admet-854	735	2	44	44	NUM
admet-854	735	3	]	]	SYM
admet-854	735	4	1rsz	1rsz	NUM
admet-854	735	5	homo	homo	NOUN
admet-854	735	6	sapiens	sapien	VERB
admet-854	735	7	289	289	NUM
admet-854	735	8	dih	dih	NOUN
admet-854	735	9	1	1	NUM
admet-854	735	10	;	;	PUNCT
admet-854	735	11	so4	so4	PROPN
admet-854	735	12	no	no	DET
admet-854	735	13	unpublished	unpublished	ADJ
admet-854	735	14	1rfg	1rfg	NUM
admet-854	735	15	homo	homo	NOUN
admet-854	735	16	sapiens	sapien	VERB
admet-854	735	17	288	288	NUM
admet-854	735	18	guanosine	guanosine	NOUN
admet-854	735	19	;	;	PUNCT
admet-854	735	20	so4	so4	PROPN
admet-854	736	1	no	no	PROPN
admet-854	737	1	[	[	X
admet-854	737	2	45	45	NUM
admet-854	737	3	]	]	SYM
admet-854	737	4	1	1	NUM
admet-854	737	5	7-[[(3r,4r)-3-(hydroxymethyl)-4	7-[[(3r,4r)-3-(hydroxymethyl)-4	NUM
admet-854	737	6	-	-	PUNCT
admet-854	737	7	oxidanyl	oxidanyl	NOUN
admet-854	737	8	-	-	PUNCT
admet-854	737	9	pyrrolidin-1	pyrrolidin-1	NUM
admet-854	737	10	-	-	PUNCT
admet-854	737	11	ium-1	ium-1	PRON
admet-854	737	12	-	-	PUNCT
admet-854	737	13	yl]methyl]-3,5	yl]methyl]-3,5	NOUN
admet-854	737	14	-	-	PUNCT
admet-854	737	15	dihydropyrrolo[3,2	dihydropyrrolo[3,2	NOUN
admet-854	737	16	-	-	PUNCT
admet-854	737	17	d]pyrimidin-4	d]pyrimidin-4	PROPN
admet-854	737	18	-	-	PUNCT
admet-854	737	19	one	one	NUM
admet-854	737	20	table	table	NOUN
admet-854	737	21	s6	s6	PROPN
admet-854	737	22	.	.	PUNCT
admet-854	738	1	the	the	DET
admet-854	738	2	characteristics	characteristic	NOUN
admet-854	738	3	of	of	ADP
admet-854	738	4	the	the	DET
admet-854	738	5	cks	ck	NOUN
admet-854	738	6	included	include	VERB
admet-854	738	7	in	in	ADP
admet-854	738	8	the	the	DET
admet-854	738	9	study	study	NOUN
admet-854	738	10	.	.	PUNCT
admet-854	739	1	pdb	pdb	PROPN
admet-854	740	1	i	i	PROPN
admet-854	740	2	d	d	PROPN
admet-854	740	3	residues	residue	VERB
admet-854	740	4	organism	organism	NOUN
admet-854	740	5	co	co	NOUN
admet-854	740	6	-	-	VERB
admet-854	740	7	crystallized	crystallize	VERB
admet-854	740	8	with	with	ADP
admet-854	740	9	substrate	substrate	NOUN
admet-854	740	10	or	or	CCONJ
admet-854	740	11	analog	analog	NOUN
admet-854	740	12	substrate	substrate	NOUN
admet-854	740	13	mutations	mutation	NOUN
admet-854	740	14	reference	reference	NOUN
admet-854	740	15	mitochondrial	mitochondrial	ADJ
admet-854	741	1	ck	ck	PROPN
admet-854	741	2	1crk	1crk	NUM
admet-854	741	3	380	380	NUM
admet-854	741	4	gallus	gallus	ADJ
admet-854	741	5	gallus	gallus	NOUN
admet-854	741	6	so4	so4	PROPN
admet-854	742	1	no	no	PROPN
admet-854	743	1	[	[	X
admet-854	743	2	46	46	NUM
admet-854	743	3	]	]	SYM
admet-854	743	4	4z9	4z9	NUM
admet-854	743	5	m	m	NOUN
admet-854	743	6	392	392	NUM
admet-854	743	7	homo	homo	NOUN
admet-854	743	8	sapiens	sapien	VERB
admet-854	743	9	adp	adp	PROPN
admet-854	743	10	1	1	NUM
admet-854	743	11	no	no	PRON
admet-854	743	12	unpublished	unpublished	ADJ
admet-854	743	13	muscle	muscle	NOUN
admet-854	743	14	ck	ck	INTJ
admet-854	744	1	2crk	2crk	NUM
admet-854	744	2	381	381	NUM
admet-854	744	3	oryctolagus	oryctolagus	ADJ
admet-854	744	4	cuniculus	cuniculus	PROPN
admet-854	744	5	so4	so4	PROPN
admet-854	744	6	no	no	PRON
admet-854	745	1	[	[	X
admet-854	745	2	48	48	NUM
admet-854	745	3	]	]	SYM
admet-854	745	4	1i0e	1i0e	NOUN
admet-854	745	5	381	381	NUM
admet-854	745	6	homo	homo	NOUN
admet-854	745	7	sapiens	sapien	VERB
admet-854	745	8	no	no	INTJ
admet-854	745	9	no	no	INTJ
admet-854	746	1	[	[	X
admet-854	746	2	48	48	NUM
admet-854	746	3	]	]	SYM
admet-854	746	4	1u6r	1u6r	PROPN
admet-854	746	5	380	380	NUM
admet-854	746	6	oryctolagus	oryctolagus	ADJ
admet-854	746	7	cuniculus	cuniculus	PROPN
admet-854	746	8	adp	adp	PROPN
admet-854	746	9	;	;	PUNCT
admet-854	746	10	iom	iom	PROPN
admet-854	746	11	2	2	NUM
admet-854	746	12	;	;	PUNCT
admet-854	746	13	no3	no3	PROPN
admet-854	746	14	;	;	PUNCT
admet-854	746	15	mg2	mg2	PROPN
admet-854	746	16	+	+	PROPN
admet-854	747	1	r134k	r134k	NOUN
admet-854	747	2	[	[	X
admet-854	747	3	49	49	NUM
admet-854	747	4	]	]	PUNCT
admet-854	747	5	brain	brain	NOUN
admet-854	747	6	ck	ck	INTJ
admet-854	748	1	3drb	3drb	NUM
admet-854	748	2	381	381	NUM
admet-854	748	3	homo	homo	NOUN
admet-854	748	4	sapiens	sapiens	PROPN
admet-854	748	5	adp	adp	PROPN
admet-854	748	6	;	;	PUNCT
admet-854	748	7	mg2	mg2	PROPN
admet-854	748	8	+	+	PROPN
admet-854	748	9	no	no	PRON
admet-854	749	1	[	[	NOUN
admet-854	749	2	50	50	NUM
admet-854	749	3	]	]	X
admet-854	749	4	3dre	3dre	NUM
admet-854	749	5	381	381	NUM
admet-854	749	6	homo	homo	NOUN
admet-854	749	7	sapiens	sapien	VERB
admet-854	749	8	no	no	DET
admet-854	749	9	no	no	INTJ
admet-854	750	1	[	[	X
admet-854	750	2	50	50	NUM
admet-854	750	3	]	]	PUNCT
admet-854	750	4	1qh4	1qh4	NUM
admet-854	750	5	380	380	NUM
admet-854	750	6	gallus	gallus	ADJ
admet-854	750	7	gallus	gallus	ADJ
admet-854	750	8	acetate	acetate	NOUN
admet-854	750	9	ion	ion	NOUN
admet-854	750	10	;	;	PUNCT
admet-854	750	11	ca2	ca2	PROPN
admet-854	751	1	+	+	CCONJ
admet-854	751	2	no	no	DET
admet-854	751	3	[	[	X
admet-854	751	4	51	51	NUM
admet-854	751	5	]	]	X
admet-854	751	6	retinal	retinal	ADJ
admet-854	751	7	ck	ck	PROPN
admet-854	751	8	1g0w	1g0w	NUM
admet-854	751	9	380	380	NUM
admet-854	751	10	bos	bos	PROPN
admet-854	751	11	taurus	taurus	PROPN
admet-854	751	12	so4	so4	PROPN
admet-854	752	1	no	no	PROPN
admet-854	753	1	[	[	X
admet-854	753	2	52	52	NUM
admet-854	753	3	]	]	SYM
admet-854	753	4	1	1	NUM
admet-854	753	5	adenosine-5’-diphosphate	adenosine-5’-diphosphate	ADJ
admet-854	753	6	;	;	PUNCT
admet-854	753	7	2	2	NUM
admet-854	753	8	(	(	PUNCT
admet-854	753	9	diaminomethyl	diaminomethyl	NOUN
admet-854	753	10	-	-	PUNCT
admet-854	753	11	methyl	methyl	NOUN
admet-854	753	12	-	-	PUNCT
admet-854	753	13	amino)-acetic	amino)-acetic	ADJ
admet-854	753	14	acid	acid	NOUN
admet-854	753	15	http://dx.doi.org/10.5599/admet.854	http://dx.doi.org/10.5599/admet.854	NOUN