id	sid	tid	token	lemma	pos
admet-881	1	1	intestinal	intestinal	ADJ
admet-881	1	2	absorption	absorption	NOUN
admet-881	1	3	of	of	ADP
admet-881	1	4	bcs	bcs	NOUN
admet-881	1	5	class	class	NOUN
admet-881	1	6	ii	ii	NOUN
admet-881	1	7	drugs	drug	NOUN
admet-881	1	8	administered	administer	VERB
admet-881	1	9	as	as	ADP
admet-881	1	10	nanoparticles	nanoparticle	NOUN
admet-881	1	11	:	:	PUNCT
admet-881	1	12	a	a	DET
admet-881	1	13	review	review	NOUN
admet-881	1	14	based	base	VERB
admet-881	1	15	on	on	ADP
admet-881	1	16	in	in	ADP
admet-881	1	17	vivo	vivo	ADJ
admet-881	1	18	data	datum	NOUN
admet-881	1	19	from	from	ADP
admet-881	1	20	intestinal	intestinal	ADJ
admet-881	1	21	perfusion	perfusion	NOUN
admet-881	1	22	models	model	NOUN
admet-881	1	23	doi	doi	NOUN
admet-881	1	24	:	:	PUNCT
admet-881	1	25	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	1	26	375	375	NUM
admet-881	1	27	admet	admet	X
admet-881	1	28	&	&	CCONJ
admet-881	1	29	dmpk	dmpk	PROPN
admet-881	1	30	8(4	8(4	NOUN
admet-881	1	31	)	)	PUNCT
admet-881	1	32	(	(	PUNCT
admet-881	1	33	2020	2020	NUM
admet-881	1	34	)	)	PUNCT
admet-881	1	35	375	375	NUM
admet-881	1	36	-	-	SYM
admet-881	1	37	390	390	NUM
admet-881	1	38	;	;	PUNCT
admet-881	1	39	doi	doi	NOUN
admet-881	1	40	:	:	PUNCT
admet-881	1	41	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	1	42	open	open	ADJ
admet-881	1	43	access	access	NOUN
admet-881	1	44	:	:	PUNCT
admet-881	1	45	issn	issn	PROPN
admet-881	1	46	:	:	PUNCT
admet-881	1	47	1848	1848	NUM
admet-881	1	48	-	-	SYM
admet-881	1	49	7718	7718	NUM
admet-881	1	50	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-881	1	51	review	review	VERB
admet-881	1	52	intestinal	intestinal	ADJ
admet-881	1	53	absorption	absorption	NOUN
admet-881	1	54	of	of	ADP
admet-881	1	55	bcs	bcs	NOUN
admet-881	1	56	class	class	NOUN
admet-881	1	57	ii	ii	NOUN
admet-881	1	58	drugs	drug	NOUN
admet-881	1	59	administered	administer	VERB
admet-881	1	60	as	as	ADP
admet-881	1	61	nanoparticles	nanoparticle	NOUN
admet-881	1	62	:	:	PUNCT
admet-881	1	63	a	a	DET
admet-881	1	64	review	review	NOUN
admet-881	1	65	based	base	VERB
admet-881	1	66	on	on	ADP
admet-881	1	67	in	in	ADP
admet-881	1	68	vivo	vivo	ADJ
admet-881	1	69	data	datum	NOUN
admet-881	1	70	from	from	ADP
admet-881	1	71	intestinal	intestinal	ADJ
admet-881	1	72	perfusion	perfusion	NOUN
admet-881	1	73	models	model	NOUN
admet-881	1	74	david	david	PROPN
admet-881	1	75	dahlgren	dahlgren	PROPN
admet-881	1	76	,	,	PUNCT
admet-881	1	77	erik	erik	PROPN
admet-881	1	78	sjögren	sjögren	PROPN
admet-881	1	79	and	and	CCONJ
admet-881	1	80	hans	hans	PROPN
admet-881	1	81	lennernäs	lennernäs	PROPN
admet-881	1	82	*	*	PROPN
admet-881	1	83	department	department	PROPN
admet-881	1	84	of	of	ADP
admet-881	1	85	pharmaceutical	pharmaceutical	NOUN
admet-881	1	86	biosciences	bioscience	NOUN
admet-881	1	87	,	,	PUNCT
admet-881	1	88	translational	translational	ADJ
admet-881	1	89	drug	drug	NOUN
admet-881	1	90	discovery	discovery	NOUN
admet-881	1	91	and	and	CCONJ
admet-881	1	92	development	development	NOUN
admet-881	1	93	,	,	PUNCT
admet-881	1	94	uppsala	uppsala	PROPN
admet-881	1	95	university	university	PROPN
admet-881	1	96	,	,	PUNCT
admet-881	1	97	sweden	sweden	PROPN
admet-881	1	98	*	*	PUNCT
admet-881	1	99	corresponding	correspond	VERB
admet-881	1	100	author	author	NOUN
admet-881	1	101	:	:	PUNCT
admet-881	1	102	e	e	NOUN
admet-881	1	103	-	-	NOUN
admet-881	1	104	mail	mail	NOUN
admet-881	1	105	:	:	PUNCT
admet-881	1	106	hans.lennernas@farmbio.uu.se	hans.lennernas@farmbio.uu.se	NUM
admet-881	1	107	;	;	PUNCT
admet-881	1	108	tel	tel	PROPN
admet-881	1	109	.	.	PUNCT
admet-881	1	110	:	:	PUNCT
admet-881	2	1	+46	+46	NUM
admet-881	2	2	–	–	PUNCT
admet-881	2	3	18	18	NUM
admet-881	2	4	471	471	NUM
admet-881	2	5	4317	4317	NUM
admet-881	2	6	;	;	PUNCT
admet-881	2	7	fax	fax	NOUN
admet-881	2	8	:	:	PUNCT
admet-881	2	9	+46	+46	NUM
admet-881	2	10	–	–	PUNCT
admet-881	2	11	18	18	NUM
admet-881	2	12	471	471	NUM
admet-881	2	13	4223	4223	NUM
admet-881	2	14	received	receive	VERB
admet-881	2	15	:	:	PUNCT
admet-881	2	16	june	june	PROPN
admet-881	2	17	26	26	NUM
admet-881	2	18	,	,	PUNCT
admet-881	2	19	2020	2020	NUM
admet-881	2	20	;	;	PUNCT
admet-881	2	21	revised	revise	VERB
admet-881	2	22	:	:	PUNCT
admet-881	2	23	september	september	PROPN
admet-881	2	24	10	10	NUM
admet-881	2	25	,	,	PUNCT
admet-881	2	26	2020	2020	NUM
admet-881	2	27	;	;	PUNCT
admet-881	2	28	published	publish	VERB
admet-881	2	29	:	:	PUNCT
admet-881	2	30	september	september	PROPN
admet-881	2	31	17	17	NUM
admet-881	2	32	,	,	PUNCT
admet-881	2	33	2020	2020	NUM
admet-881	2	34	abstract	abstract	ADV
admet-881	2	35	an	an	DET
admet-881	2	36	established	establish	VERB
admet-881	2	37	pharmaceutical	pharmaceutical	ADJ
admet-881	2	38	strategy	strategy	NOUN
admet-881	2	39	to	to	PART
admet-881	2	40	increase	increase	VERB
admet-881	2	41	oral	oral	ADJ
admet-881	2	42	drug	drug	NOUN
admet-881	2	43	absorption	absorption	NOUN
admet-881	2	44	of	of	ADP
admet-881	2	45	low	low	ADJ
admet-881	2	46	solubility	solubility	NOUN
admet-881	2	47	–	–	PUNCT
admet-881	2	48	high	high	ADJ
admet-881	2	49	permeability	permeability	NOUN
admet-881	2	50	drugs	drug	NOUN
admet-881	2	51	is	be	AUX
admet-881	2	52	to	to	PART
admet-881	2	53	create	create	VERB
admet-881	2	54	nanoparticles	nanoparticle	NOUN
admet-881	2	55	of	of	ADP
admet-881	2	56	them	they	PRON
admet-881	2	57	.	.	PUNCT
admet-881	3	1	reducing	reduce	VERB
admet-881	3	2	the	the	DET
admet-881	3	3	size	size	NOUN
admet-881	3	4	of	of	ADP
admet-881	3	5	the	the	DET
admet-881	3	6	solid	solid	ADJ
admet-881	3	7	-	-	PUNCT
admet-881	3	8	state	state	NOUN
admet-881	3	9	particles	particle	NOUN
admet-881	3	10	increases	increase	VERB
admet-881	3	11	their	their	PRON
admet-881	3	12	dissolution	dissolution	NOUN
admet-881	3	13	and	and	CCONJ
admet-881	3	14	transport	transport	NOUN
admet-881	3	15	rate	rate	NOUN
admet-881	3	16	across	across	ADP
admet-881	3	17	the	the	DET
admet-881	3	18	mucus	mucus	NOUN
admet-881	3	19	barrier	barrier	NOUN
admet-881	3	20	and	and	CCONJ
admet-881	3	21	the	the	DET
admet-881	3	22	aqueous	aqueous	ADJ
admet-881	3	23	boundary	boundary	ADJ
admet-881	3	24	layer	layer	NOUN
admet-881	3	25	.	.	PUNCT
admet-881	4	1	suspensions	suspension	NOUN
admet-881	4	2	of	of	ADP
admet-881	4	3	nanoparticles	nanoparticle	NOUN
admet-881	4	4	also	also	ADV
admet-881	4	5	sometimes	sometimes	ADV
admet-881	4	6	behave	behave	VERB
admet-881	4	7	differently	differently	ADV
admet-881	4	8	than	than	ADP
admet-881	4	9	those	those	PRON
admet-881	4	10	of	of	ADP
admet-881	4	11	larger	large	ADJ
admet-881	4	12	particles	particle	NOUN
admet-881	4	13	in	in	ADP
admet-881	4	14	the	the	DET
admet-881	4	15	fed	fed	PROPN
admet-881	4	16	state	state	NOUN
admet-881	4	17	.	.	PUNCT
admet-881	5	1	this	this	DET
admet-881	5	2	review	review	NOUN
admet-881	5	3	compares	compare	VERB
admet-881	5	4	the	the	DET
admet-881	5	5	absorption	absorption	NOUN
admet-881	5	6	mechanisms	mechanism	NOUN
admet-881	5	7	of	of	ADP
admet-881	5	8	nanoand	nanoand	NOUN
admet-881	5	9	larger	large	ADJ
admet-881	5	10	particles	particle	NOUN
admet-881	5	11	in	in	ADP
admet-881	5	12	the	the	DET
admet-881	5	13	lumen	luman	NOUN
admet-881	5	14	at	at	ADP
admet-881	5	15	different	different	ADJ
admet-881	5	16	prandial	prandial	ADJ
admet-881	5	17	states	state	NOUN
admet-881	5	18	,	,	PUNCT
admet-881	5	19	with	with	ADP
admet-881	5	20	an	an	DET
admet-881	5	21	emphasis	emphasis	NOUN
admet-881	5	22	on	on	ADP
admet-881	5	23	data	datum	NOUN
admet-881	5	24	derived	derive	VERB
admet-881	5	25	from	from	ADP
admet-881	5	26	in	in	ADP
admet-881	5	27	vivo	vivo	NOUN
admet-881	5	28	models	model	NOUN
admet-881	5	29	.	.	PUNCT
admet-881	6	1	four	four	NUM
admet-881	6	2	bsc	bsc	PROPN
admet-881	6	3	class	class	PROPN
admet-881	6	4	ii	ii	PROPN
admet-881	6	5	drugs	drug	NOUN
admet-881	6	6	—	—	PUNCT
admet-881	6	7	aprepitant	aprepitant	ADJ
admet-881	6	8	,	,	PUNCT
admet-881	6	9	cyclosporine	cyclosporine	NOUN
admet-881	6	10	,	,	PUNCT
admet-881	6	11	danazol	danazol	ADJ
admet-881	6	12	and	and	CCONJ
admet-881	6	13	fenofibrate	fenofibrate	NOUN
admet-881	6	14	—	—	PUNCT
admet-881	6	15	are	be	AUX
admet-881	6	16	discussed	discuss	VERB
admet-881	6	17	in	in	ADP
admet-881	6	18	detail	detail	NOUN
admet-881	6	19	based	base	VERB
admet-881	6	20	on	on	ADP
admet-881	6	21	information	information	NOUN
admet-881	6	22	from	from	ADP
admet-881	6	23	preclinical	preclinical	ADJ
admet-881	6	24	intestinal	intestinal	ADJ
admet-881	6	25	perfusion	perfusion	NOUN
admet-881	6	26	models	model	NOUN
admet-881	6	27	.	.	PUNCT
admet-881	7	1	©	©	PROPN
admet-881	7	2	2020	2020	NUM
admet-881	7	3	by	by	ADP
admet-881	7	4	the	the	DET
admet-881	7	5	authors	author	NOUN
admet-881	7	6	.	.	PUNCT
admet-881	8	1	this	this	DET
admet-881	8	2	article	article	NOUN
admet-881	8	3	is	be	AUX
admet-881	8	4	an	an	DET
admet-881	8	5	open	open	ADJ
admet-881	8	6	-	-	PUNCT
admet-881	8	7	access	access	NOUN
admet-881	8	8	article	article	NOUN
admet-881	8	9	distributed	distribute	VERB
admet-881	8	10	under	under	ADP
admet-881	8	11	the	the	DET
admet-881	8	12	terms	term	NOUN
admet-881	8	13	and	and	CCONJ
admet-881	8	14	conditions	condition	NOUN
admet-881	8	15	of	of	ADP
admet-881	8	16	the	the	DET
admet-881	8	17	creative	creative	ADJ
admet-881	8	18	commons	common	NOUN
admet-881	8	19	attribution	attribution	NOUN
admet-881	8	20	license	license	NOUN
admet-881	8	21	(	(	PUNCT
admet-881	8	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-881	8	23	)	)	PUNCT
admet-881	8	24	.	.	PUNCT
admet-881	9	1	keywords	keyword	VERB
admet-881	9	2	nano	nano	NOUN
admet-881	9	3	particle	particle	NOUN
admet-881	9	4	;	;	PUNCT
admet-881	9	5	nano	nano	NOUN
admet-881	9	6	drug	drug	NOUN
admet-881	9	7	delivery	delivery	NOUN
admet-881	9	8	;	;	PUNCT
admet-881	9	9	nanomedicines	nanomedicine	NOUN
admet-881	9	10	;	;	PUNCT
admet-881	9	11	intestinal	intestinal	ADJ
admet-881	9	12	perfusion	perfusion	NOUN
admet-881	9	13	;	;	PUNCT
admet-881	9	14	pharmaceutical	pharmaceutical	NOUN
admet-881	9	15	development	development	NOUN
admet-881	9	16	.	.	PUNCT
admet-881	10	1	introduction	introduction	NOUN
admet-881	10	2	rate	rate	NOUN
admet-881	10	3	and	and	CCONJ
admet-881	10	4	extent	extent	NOUN
admet-881	10	5	of	of	ADP
admet-881	10	6	drug	drug	NOUN
admet-881	10	7	absorption	absorption	NOUN
admet-881	10	8	and	and	CCONJ
admet-881	10	9	bioavailability	bioavailability	NOUN
admet-881	10	10	are	be	AUX
admet-881	10	11	critical	critical	ADJ
admet-881	10	12	pharmacokinetic	pharmacokinetic	ADJ
admet-881	10	13	(	(	PUNCT
admet-881	10	14	pk	pk	NOUN
admet-881	10	15	)	)	PUNCT
admet-881	10	16	parameters	parameter	NOUN
admet-881	10	17	for	for	ADP
admet-881	10	18	oral	oral	ADJ
admet-881	10	19	pharmaceutical	pharmaceutical	ADJ
admet-881	10	20	products	product	NOUN
admet-881	10	21	.	.	PUNCT
admet-881	11	1	these	these	DET
admet-881	11	2	parameters	parameter	NOUN
admet-881	11	3	are	be	AUX
admet-881	11	4	determined	determine	VERB
admet-881	11	5	and	and	CCONJ
admet-881	11	6	characterized	characterize	VERB
admet-881	11	7	in	in	ADP
admet-881	11	8	drug	drug	NOUN
admet-881	11	9	discovery	discovery	NOUN
admet-881	11	10	and	and	CCONJ
admet-881	11	11	in	in	ADP
admet-881	11	12	preclinical	preclinical	ADJ
admet-881	11	13	and	and	CCONJ
admet-881	11	14	clinical	clinical	ADJ
admet-881	11	15	development	development	NOUN
admet-881	11	16	of	of	ADP
admet-881	11	17	a	a	DET
admet-881	11	18	drug	drug	NOUN
admet-881	11	19	product	product	NOUN
admet-881	11	20	.	.	PUNCT
admet-881	12	1	successful	successful	ADJ
admet-881	12	2	design	design	NOUN
admet-881	12	3	and	and	CCONJ
admet-881	12	4	development	development	NOUN
admet-881	12	5	of	of	ADP
admet-881	12	6	any	any	DET
admet-881	12	7	oral	oral	ADJ
admet-881	12	8	drug	drug	NOUN
admet-881	12	9	product	product	NOUN
admet-881	12	10	requires	require	VERB
admet-881	12	11	understanding	understand	VERB
admet-881	12	12	the	the	DET
admet-881	12	13	complex	complex	ADJ
admet-881	12	14	interplay	interplay	NOUN
admet-881	12	15	between	between	ADP
admet-881	12	16	the	the	DET
admet-881	12	17	pharmacokinetic	pharmacokinetic	ADJ
admet-881	12	18	parameters	parameter	NOUN
admet-881	12	19	,	,	PUNCT
admet-881	12	20	manufacturing	manufacturing	NOUN
admet-881	12	21	methods	method	NOUN
admet-881	12	22	,	,	PUNCT
admet-881	12	23	pharmaceutical	pharmaceutical	NOUN
admet-881	12	24	excipients	excipient	NOUN
admet-881	12	25	,	,	PUNCT
admet-881	12	26	and	and	CCONJ
admet-881	12	27	biopharmaceutics	biopharmaceutic	NOUN
admet-881	12	28	,	,	PUNCT
admet-881	12	29	as	as	ADV
admet-881	12	30	well	well	ADV
admet-881	12	31	as	as	ADP
admet-881	12	32	potency	potency	NOUN
admet-881	12	33	(	(	PUNCT
admet-881	12	34	the	the	DET
admet-881	12	35	major	major	ADJ
admet-881	12	36	driver	driver	NOUN
admet-881	12	37	for	for	ADP
admet-881	12	38	drug	drug	NOUN
admet-881	12	39	discovery	discovery	NOUN
admet-881	12	40	)	)	PUNCT
admet-881	12	41	,	,	PUNCT
admet-881	12	42	pharmacology	pharmacology	NOUN
admet-881	12	43	,	,	PUNCT
admet-881	12	44	safety	safety	NOUN
admet-881	12	45	,	,	PUNCT
admet-881	12	46	and	and	CCONJ
admet-881	12	47	toxicity	toxicity	NOUN
admet-881	12	48	.	.	PUNCT
admet-881	13	1	gastrointestinal	gastrointestinal	ADJ
admet-881	13	2	(	(	PUNCT
admet-881	13	3	gi	gi	NOUN
admet-881	13	4	)	)	PUNCT
admet-881	13	5	absorption	absorption	NOUN
admet-881	13	6	and	and	CCONJ
admet-881	13	7	bioavailability	bioavailability	NOUN
admet-881	13	8	are	be	AUX
admet-881	13	9	both	both	PRON
admet-881	13	10	affected	affect	VERB
admet-881	13	11	by	by	ADP
admet-881	13	12	a	a	DET
admet-881	13	13	number	number	NOUN
admet-881	13	14	of	of	ADP
admet-881	13	15	pharmaceutical	pharmaceutical	NOUN
admet-881	13	16	,	,	PUNCT
admet-881	13	17	biopharmaceutical	biopharmaceutical	NOUN
admet-881	13	18	and	and	CCONJ
admet-881	13	19	physiological	physiological	ADJ
admet-881	13	20	processes	process	NOUN
admet-881	13	21	.	.	PUNCT
admet-881	14	1	despite	despite	SCONJ
admet-881	14	2	comprehensive	comprehensive	ADJ
admet-881	14	3	knowledge	knowledge	NOUN
admet-881	14	4	about	about	ADP
admet-881	14	5	drug	drug	NOUN
admet-881	14	6	-	-	PUNCT
admet-881	14	7	product	product	NOUN
admet-881	14	8	related	relate	VERB
admet-881	14	9	and	and	CCONJ
admet-881	14	10	physiological	physiological	ADJ
admet-881	14	11	properties	property	NOUN
admet-881	14	12	in	in	ADP
admet-881	14	13	gi	gi	NOUN
admet-881	14	14	absorption	absorption	NOUN
admet-881	14	15	,	,	PUNCT
admet-881	14	16	many	many	ADJ
admet-881	14	17	drug	drug	NOUN
admet-881	14	18	candidates	candidate	NOUN
admet-881	14	19	and	and	CCONJ
admet-881	14	20	drugs	drug	NOUN
admet-881	14	21	have	have	VERB
admet-881	14	22	suboptimal	suboptimal	ADJ
admet-881	14	23	biopharmaceutical	biopharmaceutical	ADJ
admet-881	14	24	properties	property	NOUN
admet-881	14	25	for	for	ADP
admet-881	14	26	oral	oral	ADJ
admet-881	14	27	dosing	dosing	ADJ
admet-881	15	1	[	[	X
admet-881	15	2	1,2	1,2	NUM
admet-881	15	3	]	]	PUNCT
admet-881	15	4	.	.	PUNCT
admet-881	16	1	several	several	ADJ
admet-881	16	2	challenging	challenging	ADJ
admet-881	16	3	drug	drug	NOUN
admet-881	16	4	candidates	candidate	NOUN
admet-881	16	5	are	be	AUX
admet-881	16	6	listed	list	VERB
admet-881	16	7	in	in	ADP
admet-881	16	8	the	the	DET
admet-881	16	9	biopharmaceutical	biopharmaceutical	ADJ
admet-881	16	10	classification	classification	NOUN
admet-881	16	11	system	system	NOUN
admet-881	16	12	(	(	PUNCT
admet-881	16	13	bcs	bcs	NOUN
admet-881	16	14	)	)	PUNCT
admet-881	16	15	as	as	ADP
admet-881	16	16	class	class	PROPN
admet-881	16	17	ii	ii	PROPN
admet-881	16	18	,	,	PUNCT
admet-881	16	19	iii	iii	PROPN
admet-881	16	20	,	,	PUNCT
admet-881	16	21	or	or	CCONJ
admet-881	16	22	iv	iv	NUM
admet-881	16	23	,	,	PUNCT
admet-881	16	24	for	for	ADP
admet-881	16	25	which	which	PRON
admet-881	16	26	absorption	absorption	NOUN
admet-881	16	27	is	be	AUX
admet-881	16	28	limited	limit	VERB
admet-881	16	29	by	by	ADP
admet-881	16	30	solubility	solubility	NOUN
admet-881	16	31	properties	property	NOUN
admet-881	16	32	in	in	ADP
admet-881	16	33	gi	gi	NOUN
admet-881	16	34	luminal	luminal	ADJ
admet-881	16	35	fluids	fluid	NOUN
admet-881	16	36	and/or	and/or	CCONJ
admet-881	16	37	intestinal	intestinal	ADJ
admet-881	16	38	permeability	permeability	NOUN
admet-881	16	39	[	[	X
admet-881	16	40	3	3	NUM
admet-881	16	41	]	]	PUNCT
admet-881	16	42	.	.	PUNCT
admet-881	17	1	limitations	limitation	NOUN
admet-881	17	2	in	in	ADP
admet-881	17	3	any	any	DET
admet-881	17	4	one	one	NUM
admet-881	17	5	of	of	ADP
admet-881	17	6	the	the	DET
admet-881	17	7	main	main	ADJ
admet-881	17	8	bcs	bcs	NOUN
admet-881	17	9	parameters	parameter	NOUN
admet-881	17	10	may	may	AUX
admet-881	17	11	reduce	reduce	VERB
admet-881	17	12	the	the	DET
admet-881	17	13	rate	rate	NOUN
admet-881	17	14	and	and	CCONJ
admet-881	17	15	fraction	fraction	NOUN
admet-881	17	16	dose	dose	NOUN
admet-881	17	17	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	17	18	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	17	19	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-881	17	20	mailto:hans.lennernas@farmbio.uu.se	mailto:hans.lennernas@farmbio.uu.se	PROPN
admet-881	17	21	mailto:hans.lennernas@farmbio.uu.se	mailto:hans.lennernas@farmbio.uu.se	PROPN
admet-881	17	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-881	17	23	h.	h.	PROPN
admet-881	17	24	lennernäs	lennernäs	PROPN
admet-881	17	25	et	et	PROPN
admet-881	17	26	al	al	PROPN
admet-881	17	27	.	.	PROPN
admet-881	17	28	admet	admet	PROPN
admet-881	17	29	&	&	CCONJ
admet-881	17	30	dmpk	dmpk	PROPN
admet-881	17	31	8(4	8(4	NOUN
admet-881	17	32	)	)	PUNCT
admet-881	17	33	(	(	PUNCT
admet-881	17	34	2020	2020	NUM
admet-881	17	35	)	)	PUNCT
admet-881	17	36	375	375	NUM
admet-881	17	37	-	-	SYM
admet-881	17	38	390	390	NUM
admet-881	17	39	376	376	NUM
admet-881	17	40	absorbed	absorb	VERB
admet-881	17	41	(	(	PUNCT
admet-881	17	42	fabs	fab	NOUN
admet-881	17	43	)	)	PUNCT
admet-881	17	44	from	from	ADP
admet-881	17	45	conventional	conventional	ADJ
admet-881	17	46	,	,	PUNCT
admet-881	17	47	oral	oral	ADJ
admet-881	17	48	dosage	dosage	NOUN
admet-881	17	49	forms	form	NOUN
admet-881	17	50	intended	intend	VERB
admet-881	17	51	for	for	ADP
admet-881	17	52	immediate	immediate	ADJ
admet-881	17	53	release	release	NOUN
admet-881	17	54	in	in	ADP
admet-881	17	55	the	the	DET
admet-881	17	56	gi	gi	NOUN
admet-881	17	57	lumen	luman	NOUN
admet-881	17	58	.	.	PUNCT
admet-881	18	1	drugs	drug	NOUN
admet-881	18	2	with	with	ADP
admet-881	18	3	low	low	ADJ
admet-881	18	4	solubility	solubility	NOUN
admet-881	18	5	and/or	and/or	CCONJ
admet-881	18	6	low	low	ADJ
admet-881	18	7	intestinal	intestinal	ADJ
admet-881	18	8	permeability	permeability	NOUN
admet-881	18	9	also	also	ADV
admet-881	18	10	tend	tend	VERB
admet-881	18	11	to	to	PART
admet-881	18	12	have	have	VERB
admet-881	18	13	highly	highly	ADV
admet-881	18	14	variable	variable	ADJ
admet-881	18	15	plasma	plasma	NOUN
admet-881	18	16	exposure	exposure	NOUN
admet-881	18	17	profiles	profile	NOUN
admet-881	18	18	within	within	ADP
admet-881	18	19	and	and	CCONJ
admet-881	18	20	between	between	ADP
admet-881	18	21	individuals	individual	NOUN
admet-881	18	22	[	[	X
admet-881	18	23	4,5	4,5	NUM
admet-881	18	24	]	]	PUNCT
admet-881	18	25	.	.	PUNCT
admet-881	19	1	in	in	ADP
admet-881	19	2	the	the	DET
admet-881	19	3	design	design	NOUN
admet-881	19	4	and	and	CCONJ
admet-881	19	5	development	development	NOUN
admet-881	19	6	of	of	ADP
admet-881	19	7	oral	oral	ADJ
admet-881	19	8	drug	drug	NOUN
admet-881	19	9	dosage	dosage	NOUN
admet-881	19	10	forms	form	NOUN
admet-881	19	11	,	,	PUNCT
admet-881	19	12	a	a	DET
admet-881	19	13	pk	pk	NOUN
admet-881	19	14	assessment	assessment	NOUN
admet-881	19	15	is	be	AUX
admet-881	19	16	fundamental	fundamental	ADJ
admet-881	19	17	for	for	ADP
admet-881	19	18	distinguishing	distinguish	VERB
admet-881	19	19	between	between	ADP
admet-881	19	20	fabs	fab	NOUN
admet-881	19	21	and	and	CCONJ
admet-881	19	22	bioavailability	bioavailability	NOUN
admet-881	19	23	(	(	PUNCT
admet-881	19	24	f	f	PROPN
admet-881	19	25	or	or	CCONJ
admet-881	19	26	ba	ba	NOUN
admet-881	19	27	)	)	PUNCT
admet-881	20	1	[	[	X
admet-881	20	2	6	6	NUM
admet-881	20	3	]	]	PUNCT
admet-881	20	4	.	.	PUNCT
admet-881	21	1	in	in	ADP
admet-881	21	2	general	general	ADJ
admet-881	21	3	pharmacology	pharmacology	NOUN
admet-881	21	4	,	,	PUNCT
admet-881	21	5	f	f	PROPN
admet-881	21	6	represents	represent	VERB
admet-881	21	7	the	the	DET
admet-881	21	8	fraction	fraction	NOUN
admet-881	21	9	of	of	ADP
admet-881	21	10	an	an	DET
admet-881	21	11	administered	administered	ADJ
admet-881	21	12	dose	dose	NOUN
admet-881	21	13	of	of	ADP
admet-881	21	14	a	a	DET
admet-881	21	15	drug	drug	NOUN
admet-881	21	16	that	that	PRON
admet-881	21	17	reaches	reach	VERB
admet-881	21	18	the	the	DET
admet-881	21	19	systemic	systemic	ADJ
admet-881	21	20	circulation	circulation	NOUN
admet-881	21	21	in	in	ADP
admet-881	21	22	intact	intact	ADJ
admet-881	21	23	form	form	NOUN
admet-881	21	24	(	(	PUNCT
admet-881	21	25	parent	parent	NOUN
admet-881	21	26	drug	drug	NOUN
admet-881	21	27	)	)	PUNCT
admet-881	21	28	and	and	CCONJ
admet-881	21	29	it	it	PRON
admet-881	21	30	is	be	AUX
admet-881	21	31	one	one	NUM
admet-881	21	32	of	of	ADP
admet-881	21	33	the	the	DET
admet-881	21	34	primary	primary	ADJ
admet-881	21	35	pk	pk	NOUN
admet-881	21	36	properties	property	NOUN
admet-881	21	37	of	of	ADP
admet-881	21	38	any	any	DET
admet-881	21	39	drug	drug	NOUN
admet-881	21	40	product	product	NOUN
admet-881	21	41	.	.	PUNCT
admet-881	22	1	it	it	PRON
admet-881	22	2	is	be	AUX
admet-881	22	3	assumed	assume	VERB
admet-881	22	4	that	that	SCONJ
admet-881	22	5	the	the	DET
admet-881	22	6	bioavailability	bioavailability	NOUN
admet-881	22	7	for	for	ADP
admet-881	22	8	any	any	DET
admet-881	22	9	drug	drug	NOUN
admet-881	22	10	product	product	NOUN
admet-881	22	11	given	give	VERB
admet-881	22	12	intravenously	intravenously	ADV
admet-881	22	13	is	be	AUX
admet-881	22	14	100	100	NUM
admet-881	22	15	%	%	NOUN
admet-881	22	16	and	and	CCONJ
admet-881	22	17	the	the	DET
admet-881	22	18	bioavailability	bioavailability	NOUN
admet-881	22	19	of	of	ADP
admet-881	22	20	any	any	DET
admet-881	22	21	orally	orally	ADV
admet-881	22	22	administered	administer	VERB
admet-881	22	23	dosage	dosage	NOUN
admet-881	22	24	form	form	NOUN
admet-881	22	25	is	be	AUX
admet-881	22	26	measured	measure	VERB
admet-881	22	27	relative	relative	ADJ
admet-881	22	28	to	to	ADP
admet-881	22	29	this	this	DET
admet-881	22	30	value	value	NOUN
admet-881	22	31	,	,	PUNCT
admet-881	22	32	calculated	calculate	VERB
admet-881	22	33	as	as	ADP
admet-881	22	34	the	the	DET
admet-881	22	35	ratio	ratio	NOUN
admet-881	22	36	of	of	ADP
admet-881	22	37	dose	dose	NOUN
admet-881	22	38	-	-	PUNCT
admet-881	22	39	normalized	normalize	VERB
admet-881	22	40	plasma	plasma	NOUN
admet-881	22	41	exposure	exposure	NOUN
admet-881	22	42	.	.	PUNCT
admet-881	23	1	many	many	ADJ
admet-881	23	2	of	of	ADP
admet-881	23	3	the	the	DET
admet-881	23	4	drug	drug	NOUN
admet-881	23	5	candidates	candidate	NOUN
admet-881	23	6	currently	currently	ADV
admet-881	23	7	generated	generate	VERB
admet-881	23	8	in	in	ADP
admet-881	23	9	early	early	ADJ
admet-881	23	10	development	development	NOUN
admet-881	23	11	are	be	AUX
admet-881	23	12	lipophilic	lipophilic	ADJ
admet-881	23	13	.	.	PUNCT
admet-881	24	1	this	this	PRON
admet-881	24	2	is	be	AUX
admet-881	24	3	probably	probably	ADV
admet-881	24	4	a	a	DET
admet-881	24	5	result	result	NOUN
admet-881	24	6	of	of	ADP
admet-881	24	7	the	the	DET
admet-881	24	8	drug	drug	NOUN
admet-881	24	9	discovery	discovery	NOUN
admet-881	24	10	lead	lead	NOUN
admet-881	24	11	-	-	PUNCT
admet-881	24	12	finding	find	VERB
admet-881	24	13	techniques	technique	NOUN
admet-881	24	14	applied	apply	VERB
admet-881	24	15	,	,	PUNCT
admet-881	24	16	which	which	PRON
admet-881	24	17	rely	rely	VERB
admet-881	24	18	on	on	ADP
admet-881	24	19	in	in	ADP
admet-881	24	20	silico	silico	NOUN
admet-881	24	21	and	and	CCONJ
admet-881	24	22	in	in	ADP
admet-881	24	23	vitro	vitro	X
admet-881	24	24	screening	screen	VERB
admet-881	24	25	of	of	ADP
admet-881	24	26	receptor	receptor	NOUN
admet-881	24	27	-	-	PUNCT
admet-881	24	28	ligand	ligand	NOUN
admet-881	24	29	interactions	interaction	NOUN
admet-881	24	30	[	[	X
admet-881	24	31	7	7	NUM
admet-881	24	32	-	-	SYM
admet-881	24	33	9	9	NUM
admet-881	24	34	]	]	PUNCT
admet-881	24	35	.	.	PUNCT
admet-881	25	1	these	these	DET
admet-881	25	2	molecular	molecular	ADJ
admet-881	25	3	screening	screening	NOUN
admet-881	25	4	tools	tool	NOUN
admet-881	25	5	propose	propose	VERB
admet-881	25	6	candidates	candidate	NOUN
admet-881	25	7	with	with	ADP
admet-881	25	8	a	a	DET
admet-881	25	9	high	high	ADJ
admet-881	25	10	potential	potential	NOUN
admet-881	25	11	for	for	ADP
admet-881	25	12	interacting	interact	VERB
admet-881	25	13	with	with	ADP
admet-881	25	14	designated	designate	VERB
admet-881	25	15	target	target	NOUN
admet-881	25	16	receptors	receptor	NOUN
admet-881	25	17	.	.	PUNCT
admet-881	26	1	as	as	SCONJ
admet-881	26	2	these	these	DET
admet-881	26	3	receptors	receptor	NOUN
admet-881	26	4	are	be	AUX
admet-881	26	5	usually	usually	ADV
admet-881	26	6	associated	associate	VERB
admet-881	26	7	with	with	ADP
admet-881	26	8	lipophilic	lipophilic	ADJ
admet-881	26	9	drugs	drug	NOUN
admet-881	26	10	,	,	PUNCT
admet-881	26	11	the	the	DET
admet-881	26	12	tools	tool	NOUN
admet-881	26	13	invariably	invariably	ADV
admet-881	26	14	select	select	VERB
admet-881	26	15	lipophilic	lipophilic	ADJ
admet-881	26	16	candidates	candidate	NOUN
admet-881	26	17	[	[	X
admet-881	26	18	10	10	NUM
admet-881	26	19	-	-	SYM
admet-881	26	20	12	12	NUM
admet-881	26	21	]	]	PUNCT
admet-881	26	22	.	.	PUNCT
admet-881	27	1	while	while	SCONJ
admet-881	27	2	lipophilic	lipophilic	ADJ
admet-881	27	3	active	active	ADJ
admet-881	27	4	pharmaceutical	pharmaceutical	ADJ
admet-881	27	5	ingredients	ingredient	NOUN
admet-881	27	6	(	(	PUNCT
admet-881	27	7	apis	apis	ADJ
admet-881	27	8	)	)	PUNCT
admet-881	27	9	tend	tend	VERB
admet-881	27	10	to	to	PART
admet-881	27	11	have	have	VERB
admet-881	27	12	more	more	ADJ
admet-881	27	13	than	than	ADP
admet-881	27	14	sufficiently	sufficiently	ADV
admet-881	27	15	high	high	ADJ
admet-881	27	16	effective	effective	ADJ
admet-881	27	17	permeability	permeability	NOUN
admet-881	27	18	across	across	ADP
admet-881	27	19	the	the	DET
admet-881	27	20	apical	apical	ADJ
admet-881	27	21	membrane	membrane	NOUN
admet-881	27	22	of	of	ADP
admet-881	27	23	the	the	DET
admet-881	27	24	enterocytes	enterocyte	NOUN
admet-881	27	25	,	,	PUNCT
admet-881	27	26	they	they	PRON
admet-881	27	27	suffer	suffer	VERB
admet-881	27	28	from	from	ADP
admet-881	27	29	limited	limit	VERB
admet-881	27	30	solubility	solubility	NOUN
admet-881	27	31	and	and	CCONJ
admet-881	27	32	dissolution	dissolution	NOUN
admet-881	27	33	in	in	ADP
admet-881	27	34	the	the	DET
admet-881	27	35	gi	gi	NOUN
admet-881	27	36	lumen	luman	NOUN
admet-881	27	37	[	[	X
admet-881	27	38	13	13	NUM
admet-881	27	39	]	]	PUNCT
admet-881	27	40	.	.	PUNCT
admet-881	28	1	the	the	DET
admet-881	28	2	dissolution	dissolution	ADJ
admet-881	28	3	process	process	NOUN
admet-881	28	4	of	of	ADP
admet-881	28	5	a	a	DET
admet-881	28	6	solid	solid	ADJ
admet-881	28	7	api	api	NOUN
admet-881	28	8	particle	particle	NOUN
admet-881	28	9	can	can	AUX
admet-881	28	10	briefly	briefly	ADV
admet-881	28	11	be	be	AUX
admet-881	28	12	described	describe	VERB
admet-881	28	13	in	in	ADP
admet-881	28	14	two	two	NUM
admet-881	28	15	steps	step	NOUN
admet-881	28	16	.	.	PUNCT
admet-881	29	1	first	first	ADV
admet-881	29	2	,	,	PUNCT
admet-881	29	3	the	the	DET
admet-881	29	4	drug	drug	NOUN
admet-881	29	5	molecules	molecule	NOUN
admet-881	29	6	are	be	AUX
admet-881	29	7	released	release	VERB
admet-881	29	8	from	from	ADP
admet-881	29	9	the	the	DET
admet-881	29	10	particle	particle	NOUN
admet-881	29	11	surface	surface	NOUN
admet-881	29	12	to	to	ADP
admet-881	29	13	the	the	DET
admet-881	29	14	surrounding	surround	VERB
admet-881	29	15	dissolution	dissolution	NOUN
admet-881	29	16	media	medium	NOUN
admet-881	29	17	,	,	PUNCT
admet-881	29	18	which	which	PRON
admet-881	29	19	creates	create	VERB
admet-881	29	20	a	a	DET
admet-881	29	21	saturated	saturated	ADJ
admet-881	29	22	,	,	PUNCT
admet-881	29	23	stagnant	stagnant	ADJ
admet-881	29	24	layer	layer	NOUN
admet-881	29	25	adjacent	adjacent	ADJ
admet-881	29	26	to	to	ADP
admet-881	29	27	the	the	DET
admet-881	29	28	solid	solid	ADJ
admet-881	29	29	surface	surface	NOUN
admet-881	29	30	of	of	ADP
admet-881	29	31	the	the	DET
admet-881	29	32	particle	particle	NOUN
admet-881	29	33	.	.	PUNCT
admet-881	30	1	thereafter	thereafter	ADV
admet-881	30	2	,	,	PUNCT
admet-881	30	3	the	the	DET
admet-881	30	4	released	release	VERB
admet-881	30	5	drug	drug	NOUN
admet-881	30	6	diffuses	diffuse	NOUN
admet-881	30	7	into	into	ADP
admet-881	30	8	the	the	DET
admet-881	30	9	bulk	bulk	NOUN
admet-881	30	10	of	of	ADP
admet-881	30	11	the	the	DET
admet-881	30	12	solvent	solvent	NOUN
admet-881	30	13	from	from	ADP
admet-881	30	14	regions	region	NOUN
admet-881	30	15	of	of	ADP
admet-881	30	16	high	high	ADJ
admet-881	30	17	,	,	PUNCT
admet-881	30	18	to	to	ADP
admet-881	30	19	regions	region	NOUN
admet-881	30	20	of	of	ADP
admet-881	30	21	low	low	ADJ
admet-881	30	22	,	,	PUNCT
admet-881	30	23	drug	drug	NOUN
admet-881	30	24	concentration	concentration	NOUN
admet-881	30	25	(	(	PUNCT
admet-881	30	26	schematically	schematically	NOUN
admet-881	30	27	displayed	display	VERB
admet-881	30	28	in	in	ADP
admet-881	30	29	figure	figure	NOUN
admet-881	30	30	1	1	NUM
admet-881	30	31	)	)	PUNCT
admet-881	30	32	.	.	PUNCT
admet-881	31	1	figure	figure	NOUN
admet-881	31	2	1	1	NUM
admet-881	31	3	.	.	PUNCT
admet-881	32	1	dissolution	dissolution	NOUN
admet-881	32	2	of	of	ADP
admet-881	32	3	a	a	DET
admet-881	32	4	solid	solid	ADJ
admet-881	32	5	api	api	NOUN
admet-881	32	6	releases	release	VERB
admet-881	32	7	the	the	DET
admet-881	32	8	drug	drug	NOUN
admet-881	32	9	molecule	molecule	NOUN
admet-881	32	10	,	,	PUNCT
admet-881	32	11	shown	show	VERB
admet-881	32	12	here	here	ADV
admet-881	32	13	for	for	ADP
admet-881	32	14	an	an	DET
admet-881	32	15	unrestricted	unrestricted	ADJ
admet-881	32	16	volume	volume	NOUN
admet-881	32	17	.	.	PUNCT
admet-881	33	1	the	the	DET
admet-881	33	2	rate	rate	NOUN
admet-881	33	3	of	of	ADP
admet-881	33	4	drug	drug	NOUN
admet-881	33	5	dissolution	dissolution	NOUN
admet-881	33	6	(	(	PUNCT
admet-881	33	7	dm	dm	NOUN
admet-881	33	8	/	/	SYM
admet-881	33	9	dt	dt	NOUN
admet-881	33	10	)	)	PUNCT
admet-881	33	11	is	be	AUX
admet-881	33	12	traditionally	traditionally	ADV
admet-881	33	13	described	describe	VERB
admet-881	33	14	by	by	ADP
admet-881	33	15	the	the	DET
admet-881	33	16	noyes	noyes	PROPN
admet-881	33	17	-	-	PUNCT
admet-881	33	18	whitney	whitney	PROPN
admet-881	33	19	/	/	SYM
admet-881	33	20	nernst	nernst	PROPN
admet-881	33	21	-	-	PUNCT
admet-881	33	22	brunner	brunner	NOUN
admet-881	33	23	equation	equation	NOUN
admet-881	33	24	1	1	NUM
admet-881	34	1	[	[	X
admet-881	34	2	14	14	NUM
admet-881	34	3	-	-	SYM
admet-881	34	4	18	18	NUM
admet-881	34	5	]	]	PUNCT
admet-881	34	6	:	:	PUNCT
admet-881	34	7	s	s	X
admet-881	34	8	(	(	PUNCT
admet-881	34	9	    	    	SPACE
admet-881	34	10	)	)	PUNCT
admet-881	34	11	d	d	X
admet-881	35	1	d	d	X
admet-881	35	2	td	td	NOUN
admet-881	35	3	a	a	DET
admet-881	35	4	c	c	NOUN
admet-881	35	5	cm	cm	NOUN
admet-881	35	6	t	t	NOUN
admet-881	35	7	h	h	NOUN
admet-881	36	1			VERB
admet-881	36	2			VERB
admet-881	36	3			NOUN
admet-881	36	4			NUM
admet-881	36	5	(	(	PUNCT
admet-881	36	6	1	1	NUM
admet-881	36	7	)	)	PUNCT
admet-881	36	8	where	where	SCONJ
admet-881	36	9	dm	dm	NOUN
admet-881	36	10	/	/	SYM
admet-881	36	11	dt	dt	NOUN
admet-881	36	12	is	be	AUX
admet-881	36	13	the	the	DET
admet-881	36	14	dissolution	dissolution	NOUN
admet-881	36	15	rate	rate	NOUN
admet-881	36	16	(	(	PUNCT
admet-881	36	17	i.e.	i.e.	X
admet-881	36	18	,	,	PUNCT
admet-881	36	19	the	the	DET
admet-881	36	20	change	change	NOUN
admet-881	36	21	in	in	ADP
admet-881	36	22	dissolved	dissolve	VERB
admet-881	36	23	drug	drug	NOUN
admet-881	36	24	concentration	concentration	NOUN
admet-881	36	25	with	with	ADP
admet-881	36	26	time	time	NOUN
admet-881	36	27	)	)	PUNCT
admet-881	36	28	,	,	PUNCT
admet-881	36	29	a	a	PRON
admet-881	36	30	is	be	AUX
admet-881	36	31	the	the	DET
admet-881	36	32	surface	surface	NOUN
admet-881	36	33	area	area	NOUN
admet-881	36	34	(	(	PUNCT
admet-881	36	35	4πr2	4πr2	NOUN
admet-881	36	36	)	)	PUNCT
admet-881	36	37	of	of	ADP
admet-881	36	38	the	the	DET
admet-881	36	39	particle	particle	NOUN
admet-881	36	40	available	available	ADJ
admet-881	36	41	for	for	ADP
admet-881	36	42	dissolution	dissolution	NOUN
admet-881	36	43	,	,	PUNCT
admet-881	36	44	d	d	X
admet-881	36	45	is	be	AUX
admet-881	36	46	the	the	DET
admet-881	36	47	diffusion	diffusion	NOUN
admet-881	36	48	rate	rate	NOUN
admet-881	36	49	constant	constant	ADJ
admet-881	36	50	,	,	PUNCT
admet-881	36	51	h	h	NOUN
admet-881	36	52	is	be	AUX
admet-881	36	53	the	the	DET
admet-881	36	54	thickness	thickness	NOUN
admet-881	36	55	admet	admet	PROPN
admet-881	36	56	&	&	CCONJ
admet-881	36	57	dmpk	dmpk	PROPN
admet-881	36	58	8(4	8(4	NOUN
admet-881	36	59	)	)	PUNCT
admet-881	36	60	(	(	PUNCT
admet-881	36	61	2020	2020	NUM
admet-881	36	62	)	)	PUNCT
admet-881	36	63	375	375	NUM
admet-881	36	64	-	-	SYM
admet-881	36	65	390	390	NUM
admet-881	36	66	intestinal	intestinal	ADJ
admet-881	36	67	absorption	absorption	NOUN
admet-881	36	68	of	of	ADP
admet-881	36	69	bcs	bcs	NOUN
admet-881	36	70	class	class	NOUN
admet-881	36	71	ii	ii	PROPN
admet-881	36	72	drugs	drug	NOUN
admet-881	36	73	nanoparticles	nanoparticle	NOUN
admet-881	36	74	doi	doi	NOUN
admet-881	36	75	:	:	PUNCT
admet-881	36	76	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	36	77	377	377	NUM
admet-881	36	78	of	of	ADP
admet-881	36	79	an	an	DET
admet-881	36	80	aqueous	aqueous	ADJ
admet-881	36	81	boundary	boundary	ADJ
admet-881	36	82	layer	layer	NOUN
admet-881	36	83	(	(	PUNCT
admet-881	36	84	abl	abl	NOUN
admet-881	36	85	)	)	PUNCT
admet-881	36	86	with	with	ADP
admet-881	36	87	limited	limited	ADJ
admet-881	36	88	convection	convection	NOUN
admet-881	36	89	surrounding	surround	VERB
admet-881	36	90	the	the	DET
admet-881	36	91	particle	particle	NOUN
admet-881	36	92	,	,	PUNCT
admet-881	36	93	cs	cs	PROPN
admet-881	36	94	is	be	AUX
admet-881	36	95	the	the	DET
admet-881	36	96	saturation	saturation	NOUN
admet-881	36	97	solubility	solubility	NOUN
admet-881	36	98	of	of	ADP
admet-881	36	99	the	the	DET
admet-881	36	100	drug	drug	NOUN
admet-881	36	101	at	at	ADP
admet-881	36	102	the	the	DET
admet-881	36	103	particle	particle	NOUN
admet-881	36	104	-	-	PUNCT
admet-881	36	105	dissolution	dissolution	NOUN
admet-881	36	106	media	medium	NOUN
admet-881	36	107	interface	interface	NOUN
admet-881	36	108	,	,	PUNCT
admet-881	36	109	and	and	CCONJ
admet-881	36	110	ct	ct	PRON
admet-881	36	111	the	the	DET
admet-881	36	112	dissolved	dissolve	VERB
admet-881	36	113	drug	drug	NOUN
admet-881	36	114	concentration	concentration	NOUN
admet-881	36	115	in	in	ADP
admet-881	36	116	the	the	DET
admet-881	36	117	bulk	bulk	NOUN
admet-881	36	118	at	at	ADP
admet-881	36	119	time	time	NOUN
admet-881	36	120	t.	t.	PROPN
admet-881	36	121	the	the	DET
admet-881	36	122	equation	equation	NOUN
admet-881	36	123	assumes	assume	VERB
admet-881	36	124	that	that	SCONJ
admet-881	36	125	the	the	DET
admet-881	36	126	diffusion	diffusion	NOUN
admet-881	36	127	of	of	ADP
admet-881	36	128	an	an	DET
admet-881	36	129	api	api	NOUN
admet-881	36	130	monomer	monomer	NOUN
admet-881	36	131	through	through	ADP
admet-881	36	132	the	the	DET
admet-881	36	133	abl	abl	PROPN
admet-881	36	134	is	be	AUX
admet-881	36	135	the	the	DET
admet-881	36	136	slowest	slow	ADJ
admet-881	36	137	(	(	PUNCT
admet-881	36	138	i.e.	i.e.	X
admet-881	36	139	,	,	PUNCT
admet-881	36	140	rate	rate	NOUN
admet-881	36	141	-	-	PUNCT
admet-881	36	142	limiting	limit	VERB
admet-881	36	143	)	)	PUNCT
admet-881	36	144	step	step	NOUN
admet-881	36	145	in	in	ADP
admet-881	36	146	this	this	DET
admet-881	36	147	series	series	NOUN
admet-881	36	148	of	of	ADP
admet-881	36	149	events	event	NOUN
admet-881	36	150	.	.	PUNCT
admet-881	37	1	this	this	DET
admet-881	37	2	assumption	assumption	NOUN
admet-881	37	3	allows	allow	VERB
admet-881	37	4	the	the	DET
admet-881	37	5	incorporation	incorporation	NOUN
admet-881	37	6	of	of	ADP
admet-881	37	7	fick	fick	NOUN
admet-881	37	8	’s	’s	PART
admet-881	37	9	law	law	NOUN
admet-881	37	10	of	of	ADP
admet-881	37	11	diffusion	diffusion	NOUN
admet-881	37	12	to	to	PART
admet-881	37	13	quantify	quantify	VERB
admet-881	37	14	the	the	DET
admet-881	37	15	dissolution	dissolution	NOUN
admet-881	37	16	rate	rate	NOUN
admet-881	37	17	of	of	ADP
admet-881	37	18	a	a	DET
admet-881	37	19	solid	solid	ADJ
admet-881	37	20	in	in	ADP
admet-881	37	21	its	its	PRON
admet-881	37	22	own	own	ADJ
admet-881	37	23	solution	solution	NOUN
admet-881	37	24	(	(	PUNCT
admet-881	37	25	figure	figure	NOUN
admet-881	37	26	1	1	NUM
admet-881	37	27	)	)	PUNCT
admet-881	38	1	[	[	X
admet-881	38	2	19	19	NUM
admet-881	38	3	]	]	PUNCT
admet-881	38	4	.	.	PUNCT
admet-881	39	1	the	the	DET
admet-881	39	2	noyes	noyes	PROPN
admet-881	39	3	-	-	PUNCT
admet-881	39	4	whitney	whitney	PROPN
admet-881	39	5	/	/	SYM
admet-881	39	6	nernst	nernst	PROPN
admet-881	39	7	-	-	PUNCT
admet-881	39	8	brunner	brunner	NOUN
admet-881	39	9	equation	equation	NOUN
admet-881	39	10	(	(	PUNCT
admet-881	39	11	equation	equation	NOUN
admet-881	39	12	1	1	NUM
admet-881	39	13	)	)	PUNCT
admet-881	39	14	predicts	predict	VERB
admet-881	39	15	the	the	DET
admet-881	39	16	dissolution	dissolution	NOUN
admet-881	39	17	of	of	ADP
admet-881	39	18	particles	particle	NOUN
admet-881	39	19	greater	great	ADJ
admet-881	39	20	than	than	ADP
admet-881	39	21	a	a	DET
admet-881	39	22	few	few	ADJ
admet-881	39	23	micrometres	micrometre	NOUN
admet-881	39	24	;	;	PUNCT
admet-881	39	25	however	however	ADV
admet-881	39	26	,	,	PUNCT
admet-881	39	27	this	this	DET
admet-881	39	28	equation	equation	NOUN
admet-881	39	29	may	may	AUX
admet-881	39	30	not	not	PART
admet-881	39	31	be	be	AUX
admet-881	39	32	optimal	optimal	ADJ
admet-881	39	33	for	for	ADP
admet-881	39	34	nanoparticles	nanoparticle	NOUN
admet-881	39	35	[	[	X
admet-881	39	36	16	16	NUM
admet-881	39	37	]	]	PUNCT
admet-881	39	38	.	.	PUNCT
admet-881	40	1	in	in	ADP
admet-881	40	2	addition	addition	NOUN
admet-881	40	3	to	to	ADP
admet-881	40	4	increasing	increase	VERB
admet-881	40	5	total	total	ADJ
admet-881	40	6	surface	surface	NOUN
admet-881	40	7	area	area	NOUN
admet-881	40	8	,	,	PUNCT
admet-881	40	9	it	it	PRON
admet-881	40	10	should	should	AUX
admet-881	40	11	also	also	ADV
admet-881	40	12	be	be	AUX
admet-881	40	13	mentioned	mention	VERB
admet-881	40	14	that	that	SCONJ
admet-881	40	15	particle	particle	NOUN
admet-881	40	16	size	size	NOUN
admet-881	40	17	reduction	reduction	NOUN
admet-881	40	18	(	(	PUNCT
admet-881	40	19	down	down	ADP
admet-881	40	20	to	to	ADP
admet-881	40	21	about	about	ADP
admet-881	40	22	1	1	NUM
admet-881	40	23	µm	µm	NOUN
admet-881	40	24	in	in	ADP
admet-881	40	25	diameter	diameter	NOUN
admet-881	40	26	)	)	PUNCT
admet-881	40	27	will	will	AUX
admet-881	40	28	affect	affect	VERB
admet-881	40	29	the	the	DET
admet-881	40	30	abl	abl	NOUN
admet-881	40	31	surrounding	surround	VERB
admet-881	40	32	each	each	DET
admet-881	40	33	particle	particle	NOUN
admet-881	40	34	,	,	PUNCT
admet-881	40	35	both	both	PRON
admet-881	40	36	according	accord	VERB
admet-881	40	37	to	to	ADP
admet-881	40	38	the	the	DET
admet-881	40	39	prandtl	prandtl	NOUN
admet-881	40	40	equation	equation	NOUN
admet-881	40	41	(	(	PUNCT
admet-881	40	42	equation	equation	NOUN
admet-881	40	43	2	2	NUM
admet-881	40	44	)	)	PUNCT
admet-881	40	45	but	but	CCONJ
admet-881	40	46	also	also	ADV
admet-881	40	47	by	by	ADP
admet-881	40	48	a	a	DET
admet-881	40	49	reduced	reduce	VERB
admet-881	40	50	influence	influence	NOUN
admet-881	40	51	of	of	ADP
admet-881	40	52	convection	convection	NOUN
admet-881	40	53	[	[	X
admet-881	40	54	20,21	20,21	NUM
admet-881	40	55	]	]	PUNCT
admet-881	40	56	.	.	PUNCT
admet-881	41	1	3	3	NUM
admet-881	41	2	 	 	SPACE
admet-881	41	3	(	(	PUNCT
admet-881	41	4	)	)	PUNCT
admet-881	41	5	l	l	NOUN
admet-881	41	6	h	h	NOUN
admet-881	42	1	k	k	PROPN
admet-881	42	2	v	v	ADP
admet-881	42	3			PROPN
admet-881	42	4	(	(	PUNCT
admet-881	42	5	2	2	NUM
admet-881	42	6	)	)	PUNCT
admet-881	42	7	in	in	ADP
admet-881	42	8	equation	equation	NOUN
admet-881	42	9	(	(	PUNCT
admet-881	42	10	2	2	X
admet-881	42	11	)	)	PUNCT
admet-881	42	12	h	h	NOUN
admet-881	42	13	stands	stand	VERB
admet-881	42	14	for	for	ADP
admet-881	42	15	the	the	DET
admet-881	42	16	hydrodynamic	hydrodynamic	ADJ
admet-881	42	17	boundary	boundary	ADJ
admet-881	42	18	layer	layer	NOUN
admet-881	42	19	thickness	thickness	NOUN
admet-881	42	20	,	,	PUNCT
admet-881	42	21	k	k	PROPN
admet-881	42	22	is	be	AUX
admet-881	42	23	a	a	DET
admet-881	42	24	constant	constant	ADJ
admet-881	42	25	,	,	PUNCT
admet-881	42	26	l	l	NOUN
admet-881	42	27	is	be	AUX
admet-881	42	28	the	the	DET
admet-881	42	29	length	length	NOUN
admet-881	42	30	of	of	ADP
admet-881	42	31	the	the	DET
admet-881	42	32	particle	particle	NOUN
admet-881	42	33	surface	surface	NOUN
admet-881	42	34	in	in	ADP
admet-881	42	35	the	the	DET
admet-881	42	36	flow	flow	NOUN
admet-881	42	37	direction	direction	NOUN
admet-881	42	38	,	,	PUNCT
admet-881	42	39	and	and	CCONJ
admet-881	42	40	v	v	NOUN
admet-881	42	41	is	be	AUX
admet-881	42	42	the	the	DET
admet-881	42	43	relative	relative	ADJ
admet-881	42	44	velocity	velocity	NOUN
admet-881	42	45	of	of	ADP
admet-881	42	46	the	the	DET
admet-881	42	47	liquid	liquid	NOUN
admet-881	42	48	surrounding	surround	VERB
admet-881	42	49	the	the	DET
admet-881	42	50	particle	particle	NOUN
admet-881	42	51	.	.	PUNCT
admet-881	43	1	theoretically	theoretically	ADV
admet-881	43	2	,	,	PUNCT
admet-881	43	3	a	a	DET
admet-881	43	4	reduced	reduce	VERB
admet-881	43	5	particle	particle	NOUN
admet-881	43	6	size	size	NOUN
admet-881	43	7	also	also	ADV
admet-881	43	8	increases	increase	VERB
admet-881	43	9	the	the	DET
admet-881	43	10	saturation	saturation	NOUN
admet-881	43	11	solubility	solubility	NOUN
admet-881	43	12	,	,	PUNCT
admet-881	43	13	according	accord	VERB
admet-881	43	14	to	to	ADP
admet-881	43	15	the	the	DET
admet-881	43	16	kelvin	kelvin	PROPN
admet-881	43	17	effect	effect	NOUN
admet-881	43	18	[	[	X
admet-881	43	19	20	20	NUM
admet-881	43	20	]	]	PUNCT
admet-881	43	21	.	.	PUNCT
admet-881	44	1	the	the	DET
admet-881	44	2	theorem	theorem	ADJ
admet-881	44	3	originates	originate	NOUN
admet-881	44	4	from	from	ADP
admet-881	44	5	the	the	DET
admet-881	44	6	description	description	NOUN
admet-881	44	7	of	of	ADP
admet-881	44	8	vapour	vapour	NOUN
admet-881	44	9	pressure	pressure	NOUN
admet-881	44	10	over	over	ADP
admet-881	44	11	a	a	DET
admet-881	44	12	droplet	droplet	NOUN
admet-881	44	13	,	,	PUNCT
admet-881	44	14	which	which	PRON
admet-881	44	15	increases	increase	VERB
admet-881	44	16	with	with	ADP
admet-881	44	17	droplet	droplet	ADJ
admet-881	44	18	curvature	curvature	NOUN
admet-881	44	19	.	.	PUNCT
admet-881	45	1	this	this	PRON
admet-881	45	2	theorem	theorem	VERB
admet-881	45	3	originates	originate	NOUN
admet-881	45	4	from	from	ADP
admet-881	45	5	the	the	DET
admet-881	45	6	description	description	NOUN
admet-881	45	7	of	of	ADP
admet-881	45	8	vapour	vapour	NOUN
admet-881	45	9	pressure	pressure	NOUN
admet-881	45	10	over	over	ADP
admet-881	45	11	a	a	DET
admet-881	45	12	droplet	droplet	NOUN
admet-881	45	13	,	,	PUNCT
admet-881	45	14	which	which	PRON
admet-881	45	15	increases	increase	VERB
admet-881	45	16	with	with	ADP
admet-881	45	17	droplet	droplet	ADJ
admet-881	45	18	curvature	curvature	NOUN
admet-881	45	19	.	.	PUNCT
admet-881	46	1	the	the	DET
admet-881	46	2	true	true	ADJ
admet-881	46	3	implication	implication	NOUN
admet-881	46	4	of	of	ADP
admet-881	46	5	this	this	DET
admet-881	46	6	effect	effect	NOUN
admet-881	46	7	is	be	AUX
admet-881	46	8	however	however	ADV
admet-881	46	9	difficult	difficult	ADJ
admet-881	46	10	to	to	PART
admet-881	46	11	assess	assess	VERB
admet-881	46	12	.	.	PUNCT
admet-881	47	1	first	first	ADV
admet-881	47	2	,	,	PUNCT
admet-881	47	3	as	as	SCONJ
admet-881	47	4	the	the	DET
admet-881	47	5	effect	effect	NOUN
admet-881	47	6	apply	apply	VERB
admet-881	47	7	to	to	ADP
admet-881	47	8	particles	particle	NOUN
admet-881	47	9	below	below	ADP
admet-881	47	10	10	10	NUM
admet-881	47	11	nm	nm	NOUN
admet-881	47	12	only	only	ADV
admet-881	47	13	a	a	DET
admet-881	47	14	fraction	fraction	NOUN
admet-881	47	15	(	(	PUNCT
admet-881	47	16	<	<	X
admet-881	47	17	1	1	NUM
admet-881	47	18	%	%	NOUN
admet-881	47	19	)	)	PUNCT
admet-881	47	20	of	of	ADP
admet-881	47	21	the	the	DET
admet-881	47	22	original	original	ADJ
admet-881	47	23	mass	mass	NOUN
admet-881	47	24	of	of	ADP
admet-881	47	25	a	a	DET
admet-881	47	26	conventional	conventional	ADJ
admet-881	47	27	nanosized	nanosized	ADJ
admet-881	47	28	(	(	PUNCT
admet-881	47	29	~100	~100	PROPN
admet-881	47	30	nm	nm	NOUN
admet-881	47	31	)	)	PUNCT
admet-881	47	32	system	system	NOUN
admet-881	47	33	remains	remain	VERB
admet-881	47	34	to	to	PART
admet-881	47	35	be	be	AUX
admet-881	47	36	dissolved	dissolve	VERB
admet-881	47	37	.	.	PUNCT
admet-881	48	1	secondly	secondly	ADV
admet-881	48	2	,	,	PUNCT
admet-881	48	3	in	in	ADP
admet-881	48	4	polydisperse	polydisperse	NOUN
admet-881	48	5	particles	particle	NOUN
admet-881	48	6	systems	system	NOUN
admet-881	48	7	,	,	PUNCT
admet-881	48	8	the	the	DET
admet-881	48	9	gained	gain	VERB
admet-881	48	10	dissolution	dissolution	NOUN
admet-881	48	11	of	of	ADP
admet-881	48	12	small	small	ADJ
admet-881	48	13	particles	particle	NOUN
admet-881	48	14	may	may	AUX
admet-881	48	15	be	be	AUX
admet-881	48	16	countered	counter	VERB
admet-881	48	17	by	by	ADP
admet-881	48	18	growth	growth	NOUN
admet-881	48	19	of	of	ADP
admet-881	48	20	larger	large	ADJ
admet-881	48	21	particles	particle	NOUN
admet-881	48	22	,	,	PUNCT
admet-881	48	23	according	accord	VERB
admet-881	48	24	to	to	ADP
admet-881	48	25	the	the	DET
admet-881	48	26	ostwald	ostwald	NOUN
admet-881	48	27	ripening	ripen	VERB
admet-881	48	28	principles	principle	NOUN
admet-881	48	29	.	.	PUNCT
admet-881	49	1	dissolution	dissolution	NOUN
admet-881	49	2	is	be	AUX
admet-881	49	3	typically	typically	ADV
admet-881	49	4	the	the	DET
admet-881	49	5	key	key	ADJ
admet-881	49	6	parameter	parameter	NOUN
admet-881	49	7	for	for	ADP
admet-881	49	8	the	the	DET
admet-881	49	9	assessment	assessment	NOUN
admet-881	49	10	of	of	ADP
admet-881	49	11	the	the	DET
admet-881	49	12	onset	onset	NOUN
admet-881	49	13	of	of	ADP
admet-881	49	14	action	action	NOUN
admet-881	49	15	of	of	ADP
admet-881	49	16	an	an	DET
admet-881	49	17	oral	oral	ADJ
admet-881	49	18	dosage	dosage	NOUN
admet-881	49	19	form	form	NOUN
admet-881	49	20	with	with	ADP
admet-881	49	21	bcs	bcs	NOUN
admet-881	49	22	class	class	NOUN
admet-881	49	23	ii	ii	NOUN
admet-881	49	24	drugs	drug	NOUN
admet-881	49	25	.	.	PUNCT
admet-881	50	1	the	the	DET
admet-881	50	2	dissolution	dissolution	ADJ
admet-881	50	3	rate	rate	NOUN
admet-881	50	4	of	of	ADP
admet-881	50	5	any	any	DET
admet-881	50	6	oral	oral	ADJ
admet-881	50	7	drug	drug	NOUN
admet-881	50	8	product	product	NOUN
admet-881	50	9	is	be	AUX
admet-881	50	10	determined	determine	VERB
admet-881	50	11	by	by	ADP
admet-881	50	12	the	the	DET
admet-881	50	13	physicochemical	physicochemical	ADJ
admet-881	50	14	properties	property	NOUN
admet-881	50	15	of	of	ADP
admet-881	50	16	the	the	DET
admet-881	50	17	substance	substance	NOUN
admet-881	50	18	,	,	PUNCT
admet-881	50	19	dosage	dosage	NOUN
admet-881	50	20	form	form	NOUN
admet-881	50	21	composition	composition	NOUN
admet-881	50	22	and	and	CCONJ
admet-881	50	23	functions	function	NOUN
admet-881	50	24	,	,	PUNCT
admet-881	50	25	as	as	ADV
admet-881	50	26	well	well	ADV
admet-881	50	27	as	as	ADP
admet-881	50	28	by	by	ADP
admet-881	50	29	the	the	DET
admet-881	50	30	physiological	physiological	ADJ
admet-881	50	31	gi	gi	NOUN
admet-881	50	32	conditions	condition	NOUN
admet-881	50	33	(	(	PUNCT
admet-881	50	34	table	table	NOUN
admet-881	50	35	1	1	NUM
admet-881	50	36	)	)	PUNCT
admet-881	50	37	.	.	PUNCT
admet-881	51	1	the	the	DET
admet-881	51	2	latter	latter	ADJ
admet-881	51	3	varies	vary	VERB
admet-881	51	4	within	within	ADP
admet-881	51	5	and	and	CCONJ
admet-881	51	6	between	between	ADP
admet-881	51	7	subjects	subject	NOUN
admet-881	51	8	as	as	ADV
admet-881	51	9	well	well	ADV
admet-881	51	10	as	as	ADP
admet-881	51	11	between	between	ADP
admet-881	51	12	the	the	DET
admet-881	51	13	fasted	fast	VERB
admet-881	51	14	and	and	CCONJ
admet-881	51	15	fed	fed	PROPN
admet-881	51	16	state	state	NOUN
admet-881	51	17	.	.	PUNCT
admet-881	52	1	table	table	NOUN
admet-881	52	2	1	1	NUM
admet-881	52	3	.	.	X
admet-881	53	1	overview	overview	NOUN
admet-881	53	2	of	of	ADP
admet-881	53	3	the	the	DET
admet-881	53	4	pharmaceutical	pharmaceutical	NOUN
admet-881	53	5	,	,	PUNCT
admet-881	53	6	physicochemical	physicochemical	ADJ
admet-881	53	7	and	and	CCONJ
admet-881	53	8	the	the	DET
admet-881	53	9	physiological	physiological	ADJ
admet-881	53	10	properties	property	NOUN
admet-881	53	11	that	that	PRON
admet-881	53	12	influence	influence	VERB
admet-881	53	13	intestinal	intestinal	ADJ
admet-881	53	14	drug	drug	NOUN
admet-881	53	15	dissolution	dissolution	NOUN
admet-881	53	16	.	.	PUNCT
admet-881	54	1	properties	property	NOUN
admet-881	54	2	affected	affect	VERB
admet-881	54	3	by	by	ADP
admet-881	54	4	physicochemical	physicochemical	ADJ
admet-881	54	5	parameters	parameter	NOUN
admet-881	54	6	pharmaceutical	pharmaceutical	ADJ
admet-881	54	7	parameters	parameter	NOUN
admet-881	54	8	physiological	physiological	ADJ
admet-881	54	9	parameters	parameter	NOUN
admet-881	54	10	drug	drug	NOUN
admet-881	54	11	particle	particle	NOUN
admet-881	54	12	surface	surface	PROPN
admet-881	54	13	area	area	NOUN
admet-881	54	14	wettability	wettability	NOUN
admet-881	54	15	,	,	PUNCT
admet-881	54	16	particle	particle	NOUN
admet-881	54	17	size	size	NOUN
admet-881	54	18	,	,	PUNCT
admet-881	54	19	aggregation	aggregation	NOUN
admet-881	54	20	,	,	PUNCT
admet-881	54	21	surfactnts	surfactnt	VERB
admet-881	54	22	deaggregation	deaggregation	NOUN
admet-881	54	23	by	by	ADP
admet-881	54	24	surfactants	surfactant	NOUN
admet-881	54	25	in	in	ADP
admet-881	54	26	gastric	gastric	ADJ
admet-881	54	27	juice	juice	NOUN
admet-881	54	28	and	and	CCONJ
admet-881	54	29	intestinal	intestinal	ADJ
admet-881	54	30	fluid	fluid	NOUN
admet-881	54	31	(	(	PUNCT
admet-881	54	32	from	from	ADP
admet-881	54	33	bile	bile	NOUN
admet-881	54	34	)	)	PUNCT
admet-881	54	35	drug	drug	NOUN
admet-881	54	36	diffusion	diffusion	NOUN
admet-881	54	37	molecular	molecular	ADJ
admet-881	54	38	size	size	NOUN
admet-881	54	39	(	(	PUNCT
admet-881	54	40	stokes	stokes	PROPN
admet-881	54	41	–	–	PUNCT
admet-881	54	42	einstein	einstein	NOUN
admet-881	54	43	equation	equation	NOUN
admet-881	54	44	)	)	PUNCT
admet-881	54	45	viscosity	viscosity	NOUN
admet-881	54	46	of	of	ADP
admet-881	54	47	gi	gi	INTJ
admet-881	54	48	luminal	luminal	ADJ
admet-881	54	49	contents	content	NOUN
admet-881	54	50	(	(	PUNCT
admet-881	54	51	fasted	fast	VERB
admet-881	54	52	/	/	SYM
admet-881	54	53	fed	fed	PROPN
admet-881	54	54	)	)	PUNCT
admet-881	54	55	(	(	PUNCT
admet-881	54	56	stokes	stokes	PROPN
admet-881	54	57	–	–	PUNCT
admet-881	54	58	einstein	einstein	NOUN
admet-881	54	59	equation	equation	NOUN
admet-881	54	60	)	)	PUNCT
admet-881	54	61	diffusion	diffusion	NOUN
admet-881	54	62	layer	layer	NOUN
admet-881	54	63	surface	surface	NOUN
admet-881	54	64	energy	energy	NOUN
admet-881	54	65	particle	particle	NOUN
admet-881	54	66	size	size	NOUN
admet-881	54	67	motility	motility	NOUN
admet-881	54	68	patterns	pattern	NOUN
admet-881	54	69	and	and	CCONJ
admet-881	54	70	luminal	luminal	ADJ
admet-881	54	71	flow	flow	NOUN
admet-881	54	72	rate	rate	NOUN
admet-881	54	73	drug	drug	NOUN
admet-881	54	74	solubility	solubility	NOUN
admet-881	54	75	lipophilicity	lipophilicity	NOUN
admet-881	54	76	,	,	PUNCT
admet-881	54	77	pka	pka	NOUN
admet-881	54	78	,	,	PUNCT
admet-881	54	79	melting	melt	VERB
admet-881	54	80	point	point	NOUN
admet-881	54	81	crystal	crystal	NOUN
admet-881	54	82	form	form	NOUN
admet-881	54	83	,	,	PUNCT
admet-881	54	84	solubilisation	solubilisation	NOUN
admet-881	54	85	,	,	PUNCT
admet-881	54	86	precipitation	precipitation	NOUN
admet-881	54	87	,	,	PUNCT
admet-881	54	88	pharmaceutical	pharmaceutical	NOUN
admet-881	54	89	excipients	excipient	NOUN
admet-881	54	90	,	,	PUNCT
admet-881	54	91	impurities	impuritie	VERB
admet-881	54	92	luminal	luminal	ADJ
admet-881	54	93	ph	ph	VERB
admet-881	54	94	,	,	PUNCT
admet-881	54	95	buffer	buffer	NOUN
admet-881	54	96	capacity	capacity	NOUN
admet-881	54	97	,	,	PUNCT
admet-881	54	98	bile	bile	NOUN
admet-881	54	99	and	and	CCONJ
admet-881	54	100	food	food	NOUN
admet-881	54	101	composition	composition	NOUN
admet-881	54	102	amount	amount	NOUN
admet-881	54	103	of	of	ADP
admet-881	54	104	drug	drug	NOUN
admet-881	54	105	dissolved	dissolve	VERB
admet-881	54	106	see	see	VERB
admet-881	54	107	above	above	ADP
admet-881	54	108	see	see	VERB
admet-881	54	109	above	above	ADP
admet-881	54	110	intestinal	intestinal	ADJ
admet-881	54	111	permeability	permeability	NOUN
admet-881	54	112	volume	volume	NOUN
admet-881	54	113	of	of	ADP
admet-881	54	114	solvent	solvent	ADJ
admet-881	54	115	available	available	ADJ
admet-881	54	116	gi	gi	NOUN
admet-881	54	117	secretion	secretion	NOUN
admet-881	54	118	,	,	PUNCT
admet-881	54	119	fluid	fluid	ADJ
admet-881	54	120	absorption	absorption	NOUN
admet-881	54	121	,	,	PUNCT
admet-881	54	122	coadministered	coadministere	VERB
admet-881	54	123	fluids	fluid	NOUN
admet-881	54	124	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	54	125	h.	h.	PROPN
admet-881	54	126	lennernäs	lennernäs	PROPN
admet-881	54	127	et	et	PROPN
admet-881	54	128	al	al	PROPN
admet-881	54	129	.	.	PROPN
admet-881	54	130	admet	admet	PROPN
admet-881	54	131	&	&	CCONJ
admet-881	54	132	dmpk	dmpk	PROPN
admet-881	54	133	8(4	8(4	NOUN
admet-881	54	134	)	)	PUNCT
admet-881	54	135	(	(	PUNCT
admet-881	54	136	2020	2020	NUM
admet-881	54	137	)	)	PUNCT
admet-881	54	138	375	375	NUM
admet-881	54	139	-	-	SYM
admet-881	54	140	390	390	NUM
admet-881	54	141	378	378	NUM
admet-881	54	142	a	a	DET
admet-881	54	143	range	range	NOUN
admet-881	54	144	of	of	ADP
admet-881	54	145	formulation	formulation	NOUN
admet-881	54	146	strategies	strategy	NOUN
admet-881	54	147	to	to	PART
admet-881	54	148	increase	increase	VERB
admet-881	54	149	the	the	DET
admet-881	54	150	dissolution	dissolution	NOUN
admet-881	54	151	rate	rate	NOUN
admet-881	54	152	have	have	AUX
admet-881	54	153	been	be	AUX
admet-881	54	154	invented	invent	VERB
admet-881	54	155	and	and	CCONJ
admet-881	54	156	established	establish	VERB
admet-881	54	157	for	for	ADP
admet-881	54	158	oral	oral	ADJ
admet-881	54	159	drug	drug	NOUN
admet-881	54	160	products	product	NOUN
admet-881	54	161	with	with	ADP
admet-881	54	162	apis	apis	NOUN
admet-881	54	163	of	of	ADP
admet-881	54	164	low	low	ADJ
admet-881	54	165	solubility	solubility	NOUN
admet-881	55	1	[	[	X
admet-881	55	2	16	16	NUM
admet-881	55	3	]	]	PUNCT
admet-881	55	4	.	.	PUNCT
admet-881	56	1	for	for	ADP
admet-881	56	2	acidic	acidic	ADJ
admet-881	56	3	and	and	CCONJ
admet-881	56	4	basic	basic	ADJ
admet-881	56	5	apis	apis	NOUN
admet-881	56	6	,	,	PUNCT
admet-881	56	7	a	a	DET
admet-881	56	8	common	common	ADJ
admet-881	56	9	approach	approach	NOUN
admet-881	56	10	is	be	AUX
admet-881	56	11	to	to	PART
admet-881	56	12	form	form	VERB
admet-881	56	13	a	a	DET
admet-881	56	14	salt	salt	NOUN
admet-881	56	15	with	with	ADP
admet-881	56	16	the	the	DET
admet-881	56	17	charged	charge	VERB
admet-881	56	18	form	form	NOUN
admet-881	56	19	of	of	ADP
admet-881	56	20	the	the	DET
admet-881	56	21	api	api	NOUN
admet-881	56	22	.	.	PUNCT
admet-881	57	1	use	use	NOUN
admet-881	57	2	of	of	ADP
admet-881	57	3	a	a	DET
admet-881	57	4	counter	counter	NOUN
admet-881	57	5	-	-	NOUN
admet-881	57	6	ion	ion	NOUN
admet-881	57	7	increases	increase	VERB
admet-881	57	8	the	the	DET
admet-881	57	9	solubility	solubility	NOUN
admet-881	57	10	and	and	CCONJ
admet-881	57	11	dissolution	dissolution	NOUN
admet-881	57	12	rate	rate	NOUN
admet-881	57	13	in	in	ADP
admet-881	57	14	the	the	DET
admet-881	57	15	diffusion	diffusion	NOUN
admet-881	57	16	layer	layer	NOUN
admet-881	57	17	around	around	ADP
admet-881	57	18	the	the	DET
admet-881	57	19	solid	solid	ADJ
admet-881	57	20	drug	drug	NOUN
admet-881	57	21	particles	particle	NOUN
admet-881	57	22	[	[	X
admet-881	57	23	22	22	NUM
admet-881	57	24	]	]	PUNCT
admet-881	57	25	.	.	PUNCT
admet-881	58	1	three	three	NUM
admet-881	58	2	other	other	ADJ
admet-881	58	3	strategies	strategy	NOUN
admet-881	58	4	are	be	AUX
admet-881	58	5	to	to	AUX
admet-881	58	6	:	:	PUNCT
admet-881	58	7	(	(	PUNCT
admet-881	58	8	i	i	NOUN
admet-881	58	9	)	)	PUNCT
admet-881	58	10	predissolve	predissolve	VERB
admet-881	58	11	the	the	DET
admet-881	58	12	drug	drug	NOUN
admet-881	58	13	in	in	ADP
admet-881	58	14	a	a	DET
admet-881	58	15	lipid	lipid	NOUN
admet-881	58	16	-	-	PUNCT
admet-881	58	17	based	base	VERB
admet-881	58	18	formulation	formulation	NOUN
admet-881	58	19	for	for	ADP
admet-881	58	20	circumventing	circumvent	VERB
admet-881	58	21	the	the	DET
admet-881	58	22	slow	slow	ADJ
admet-881	58	23	dissolution	dissolution	NOUN
admet-881	58	24	step	step	NOUN
admet-881	58	25	;	;	PUNCT
admet-881	58	26	(	(	PUNCT
admet-881	58	27	ii	ii	NOUN
admet-881	58	28	)	)	PUNCT
admet-881	58	29	change	change	VERB
admet-881	58	30	the	the	DET
admet-881	58	31	solid	solid	ADJ
admet-881	58	32	state	state	NOUN
admet-881	58	33	properties	property	NOUN
admet-881	58	34	of	of	ADP
admet-881	58	35	the	the	DET
admet-881	58	36	apis	apis	NOUN
admet-881	58	37	from	from	ADP
admet-881	58	38	stable	stable	ADJ
admet-881	58	39	crystalline	crystalline	NOUN
admet-881	58	40	state(s	state(s	PROPN
admet-881	58	41	)	)	PUNCT
admet-881	58	42	to	to	ADP
admet-881	58	43	metastable	metastable	ADJ
admet-881	58	44	amorphous	amorphous	ADJ
admet-881	58	45	structures	structure	NOUN
admet-881	58	46	with	with	ADP
admet-881	58	47	lower	low	ADJ
admet-881	58	48	intermolecular	intermolecular	ADJ
admet-881	58	49	cohesive	cohesive	ADJ
admet-881	58	50	forces	force	NOUN
admet-881	58	51	;	;	PUNCT
admet-881	58	52	or	or	CCONJ
admet-881	58	53	(	(	PUNCT
admet-881	58	54	iii	iii	X
admet-881	58	55	)	)	PUNCT
admet-881	58	56	reduce	reduce	VERB
admet-881	58	57	the	the	DET
admet-881	58	58	particle	particle	NOUN
admet-881	58	59	size	size	NOUN
admet-881	58	60	,	,	PUNCT
admet-881	58	61	which	which	PRON
admet-881	58	62	increases	increase	VERB
admet-881	58	63	the	the	DET
admet-881	58	64	surface	surface	NOUN
admet-881	58	65	area	area	NOUN
admet-881	58	66	of	of	ADP
admet-881	58	67	the	the	DET
admet-881	58	68	api	api	NOUN
admet-881	58	69	and	and	CCONJ
admet-881	58	70	consequently	consequently	ADV
admet-881	58	71	the	the	DET
admet-881	58	72	dissolution	dissolution	ADJ
admet-881	58	73	rate	rate	NOUN
admet-881	59	1	[	[	X
admet-881	59	2	23	23	NUM
admet-881	59	3	-	-	SYM
admet-881	59	4	25	25	NUM
admet-881	59	5	]	]	PUNCT
admet-881	59	6	.	.	PUNCT
admet-881	60	1	two	two	NUM
admet-881	60	2	established	establish	VERB
admet-881	60	3	pharmaceutical	pharmaceutical	NOUN
admet-881	60	4	strategies	strategy	NOUN
admet-881	60	5	to	to	PART
admet-881	60	6	reduce	reduce	VERB
admet-881	60	7	the	the	DET
admet-881	60	8	size	size	NOUN
admet-881	60	9	of	of	ADP
admet-881	60	10	the	the	DET
admet-881	60	11	solid	solid	ADJ
admet-881	60	12	state	state	NOUN
admet-881	60	13	particles	particle	NOUN
admet-881	60	14	are	be	AUX
admet-881	60	15	to	to	PART
admet-881	60	16	create	create	VERB
admet-881	60	17	microor	microor	NOUN
admet-881	60	18	nanosuspensions	nanosuspension	NOUN
admet-881	60	19	of	of	ADP
admet-881	60	20	them	they	PRON
admet-881	60	21	[	[	X
admet-881	60	22	26	26	NUM
admet-881	60	23	]	]	PUNCT
admet-881	60	24	.	.	PUNCT
admet-881	61	1	particle	particle	NOUN
admet-881	61	2	size	size	NOUN
admet-881	61	3	reduction	reduction	NOUN
admet-881	61	4	(	(	PUNCT
admet-881	61	5	i.e.	i.e.	X
admet-881	61	6	,	,	PUNCT
admet-881	61	7	micronization	micronization	NOUN
admet-881	61	8	)	)	PUNCT
admet-881	61	9	enhance	enhance	VERB
admet-881	61	10	the	the	DET
admet-881	61	11	dissolution	dissolution	NOUN
admet-881	61	12	rate	rate	NOUN
admet-881	61	13	(	(	PUNCT
admet-881	61	14	equation	equation	NOUN
admet-881	61	15	1	1	NUM
admet-881	61	16	)	)	PUNCT
admet-881	61	17	and	and	CCONJ
admet-881	61	18	may	may	AUX
admet-881	61	19	consequently	consequently	ADV
admet-881	61	20	increase	increase	VERB
admet-881	61	21	the	the	DET
admet-881	61	22	intestinal	intestinal	ADJ
admet-881	61	23	absorption	absorption	NOUN
admet-881	61	24	and	and	CCONJ
admet-881	61	25	bioavailability	bioavailability	NOUN
admet-881	61	26	of	of	ADP
admet-881	61	27	low	low	ADJ
admet-881	61	28	solubility	solubility	NOUN
admet-881	61	29	drug	drug	NOUN
admet-881	61	30	compounds	compound	NOUN
admet-881	61	31	.	.	PUNCT
admet-881	62	1	however	however	ADV
admet-881	62	2	,	,	PUNCT
admet-881	62	3	for	for	ADP
admet-881	62	4	bcs	bcs	NOUN
admet-881	62	5	ii	ii	PROPN
admet-881	62	6	apis	apis	PROPN
admet-881	62	7	,	,	PUNCT
admet-881	62	8	nanosuspensions	nanosuspension	NOUN
admet-881	62	9	appear	appear	VERB
admet-881	62	10	to	to	PART
admet-881	62	11	offer	offer	VERB
admet-881	62	12	additional	additional	ADJ
admet-881	62	13	advantages	advantage	NOUN
admet-881	62	14	over	over	ADP
admet-881	62	15	microsuspensions	microsuspension	NOUN
admet-881	62	16	;	;	PUNCT
admet-881	62	17	the	the	DET
admet-881	62	18	enhancement	enhancement	NOUN
admet-881	62	19	of	of	ADP
admet-881	62	20	the	the	DET
admet-881	62	21	in	in	ADP
admet-881	62	22	vivo	vivo	ADJ
admet-881	62	23	dissolution	dissolution	NOUN
admet-881	62	24	rate	rate	NOUN
admet-881	62	25	required	require	VERB
admet-881	62	26	to	to	PART
admet-881	62	27	increase	increase	VERB
admet-881	62	28	the	the	DET
admet-881	62	29	gi	gi	NOUN
admet-881	62	30	drug	drug	NOUN
admet-881	62	31	absorption	absorption	NOUN
admet-881	62	32	and	and	CCONJ
admet-881	62	33	bioavailability	bioavailability	NOUN
admet-881	62	34	for	for	ADP
admet-881	62	35	low	low	ADJ
admet-881	62	36	solubility	solubility	NOUN
admet-881	62	37	drug	drug	NOUN
admet-881	62	38	candidates	candidate	NOUN
admet-881	62	39	is	be	AUX
admet-881	62	40	often	often	ADV
admet-881	62	41	greater	great	ADJ
admet-881	62	42	than	than	ADP
admet-881	62	43	what	what	PRON
admet-881	62	44	a	a	DET
admet-881	62	45	nanosuspension	nanosuspension	NOUN
admet-881	62	46	can	can	AUX
admet-881	62	47	achieve	achieve	VERB
admet-881	62	48	[	[	PUNCT
admet-881	62	49	27	27	NUM
admet-881	62	50	]	]	PUNCT
admet-881	62	51	.	.	PUNCT
admet-881	63	1	this	this	PRON
admet-881	63	2	is	be	AUX
admet-881	63	3	shown	show	VERB
admet-881	63	4	for	for	ADP
admet-881	63	5	a	a	DET
admet-881	63	6	nanosuspension	nanosuspension	NOUN
admet-881	63	7	of	of	ADP
admet-881	63	8	a	a	DET
admet-881	63	9	test	test	NOUN
admet-881	63	10	drug	drug	NOUN
admet-881	63	11	with	with	ADP
admet-881	63	12	low	low	ADJ
admet-881	63	13	molecular	molecular	ADJ
admet-881	63	14	mass	mass	NOUN
admet-881	63	15	450	450	NUM
admet-881	63	16	,	,	PUNCT
admet-881	63	17	acid	acid	PROPN
admet-881	63	18	pka	pka	PROPN
admet-881	63	19	4.7	4.7	NUM
admet-881	63	20	,	,	PUNCT
admet-881	63	21	log	log	VERB
admet-881	63	22	p	p	NOUN
admet-881	63	23	of	of	ADP
admet-881	63	24	5	5	NUM
admet-881	63	25	and	and	CCONJ
admet-881	63	26	a	a	DET
admet-881	63	27	solubility	solubility	NOUN
admet-881	63	28	of	of	ADP
admet-881	63	29	2	2	NUM
admet-881	63	30	μm	μm	NOUN
admet-881	63	31	at	at	ADP
admet-881	63	32	ph	ph	PROPN
admet-881	63	33	6.8	6.8	NUM
admet-881	64	1	[	[	X
admet-881	64	2	28	28	NUM
admet-881	64	3	]	]	PUNCT
admet-881	64	4	.	.	PUNCT
admet-881	65	1	interestingly	interestingly	ADV
admet-881	65	2	,	,	PUNCT
admet-881	65	3	with	with	ADP
admet-881	65	4	these	these	DET
admet-881	65	5	nanotechnologies	nanotechnology	NOUN
admet-881	65	6	for	for	ADP
admet-881	65	7	solid	solid	ADJ
admet-881	65	8	-	-	PUNCT
admet-881	65	9	state	state	NOUN
admet-881	65	10	particles	particle	NOUN
admet-881	65	11	,	,	PUNCT
admet-881	65	12	it	it	PRON
admet-881	65	13	is	be	AUX
admet-881	65	14	apparent	apparent	ADJ
admet-881	65	15	that	that	SCONJ
admet-881	65	16	additional	additional	ADJ
admet-881	65	17	intraluminal	intraluminal	ADJ
admet-881	65	18	mechanism(s	mechanism(s	NOUN
admet-881	65	19	)	)	PUNCT
admet-881	65	20	than	than	ADP
admet-881	65	21	dissolution	dissolution	NOUN
admet-881	65	22	must	must	AUX
admet-881	65	23	be	be	AUX
admet-881	65	24	operating	operate	VERB
admet-881	65	25	[	[	PUNCT
admet-881	65	26	29	29	NUM
admet-881	65	27	]	]	PUNCT
admet-881	65	28	.	.	PUNCT
admet-881	66	1	despite	despite	SCONJ
admet-881	66	2	the	the	DET
admet-881	66	3	advantages	advantage	NOUN
admet-881	66	4	with	with	ADP
admet-881	66	5	nanoparticles	nanoparticle	NOUN
admet-881	66	6	,	,	PUNCT
admet-881	66	7	a	a	DET
admet-881	66	8	number	number	NOUN
admet-881	66	9	of	of	ADP
admet-881	66	10	hurdles	hurdle	NOUN
admet-881	66	11	need	need	VERB
admet-881	66	12	to	to	PART
admet-881	66	13	be	be	AUX
admet-881	66	14	resolved	resolve	VERB
admet-881	66	15	with	with	ADP
admet-881	66	16	these	these	DET
admet-881	66	17	oral	oral	ADJ
admet-881	66	18	drug	drug	NOUN
admet-881	66	19	delivery	delivery	NOUN
admet-881	66	20	systems	system	NOUN
admet-881	66	21	.	.	PUNCT
admet-881	67	1	for	for	ADP
admet-881	67	2	instance	instance	NOUN
admet-881	67	3	,	,	PUNCT
admet-881	67	4	instability	instability	NOUN
admet-881	67	5	related	relate	VERB
admet-881	67	6	to	to	ADP
admet-881	67	7	aggregation	aggregation	NOUN
admet-881	67	8	of	of	ADP
admet-881	67	9	nanoparticles	nanoparticle	NOUN
admet-881	67	10	and/or	and/or	CCONJ
admet-881	67	11	to	to	ADP
admet-881	67	12	a	a	DET
admet-881	67	13	change	change	NOUN
admet-881	67	14	in	in	ADP
admet-881	67	15	the	the	DET
admet-881	67	16	solid	solid	ADJ
admet-881	67	17	-	-	PUNCT
admet-881	67	18	state	state	NOUN
admet-881	67	19	properties	property	NOUN
admet-881	67	20	of	of	ADP
admet-881	67	21	the	the	DET
admet-881	67	22	api	api	NOUN
admet-881	67	23	may	may	AUX
admet-881	67	24	reduce	reduce	VERB
admet-881	67	25	their	their	PRON
admet-881	67	26	applicability	applicability	NOUN
admet-881	67	27	in	in	ADP
admet-881	67	28	pharmaceutical	pharmaceutical	ADJ
admet-881	67	29	development	development	NOUN
admet-881	67	30	[	[	X
admet-881	67	31	30	30	NUM
admet-881	67	32	]	]	PUNCT
admet-881	67	33	.	.	PUNCT
admet-881	68	1	still	still	ADV
admet-881	68	2	,	,	PUNCT
admet-881	68	3	in	in	ADP
admet-881	68	4	oral	oral	ADJ
admet-881	68	5	product	product	NOUN
admet-881	68	6	development	development	NOUN
admet-881	68	7	,	,	PUNCT
admet-881	68	8	nanotechnologies	nanotechnology	NOUN
admet-881	68	9	have	have	AUX
admet-881	68	10	been	be	AUX
admet-881	68	11	successful	successful	ADJ
admet-881	68	12	to	to	PART
admet-881	68	13	develop	develop	VERB
admet-881	68	14	products	product	NOUN
admet-881	68	15	to	to	ADP
admet-881	68	16	a	a	DET
admet-881	68	17	clinical	clinical	ADJ
admet-881	68	18	stage	stage	NOUN
admet-881	68	19	based	base	VERB
admet-881	68	20	on	on	ADP
admet-881	68	21	solubility	solubility	NOUN
admet-881	68	22	,	,	PUNCT
admet-881	68	23	but	but	CCONJ
admet-881	68	24	mainly	mainly	ADV
admet-881	68	25	by	by	ADP
admet-881	68	26	enhancing	enhance	VERB
admet-881	68	27	dissolution	dissolution	NOUN
admet-881	68	28	.	.	PUNCT
admet-881	69	1	however	however	ADV
admet-881	69	2	,	,	PUNCT
admet-881	69	3	there	there	PRON
admet-881	69	4	is	be	VERB
admet-881	69	5	a	a	DET
admet-881	69	6	need	need	NOUN
admet-881	69	7	to	to	PART
admet-881	69	8	fully	fully	ADV
admet-881	69	9	understand	understand	VERB
admet-881	69	10	the	the	DET
admet-881	69	11	contribution	contribution	NOUN
admet-881	69	12	from	from	ADP
admet-881	69	13	enhancement	enhancement	NOUN
admet-881	69	14	of	of	ADP
admet-881	69	15	solubility	solubility	NOUN
admet-881	69	16	and/or	and/or	CCONJ
admet-881	69	17	dissolution	dissolution	NOUN
admet-881	69	18	as	as	ADV
admet-881	69	19	well	well	ADV
admet-881	69	20	as	as	ADP
admet-881	69	21	additional	additional	ADJ
admet-881	69	22	absorption	absorption	NOUN
admet-881	69	23	mechanisms	mechanism	NOUN
admet-881	69	24	,	,	PUNCT
admet-881	69	25	such	such	ADJ
admet-881	69	26	as	as	ADP
admet-881	69	27	particle	particle	NOUN
admet-881	69	28	drifting	drift	VERB
admet-881	69	29	in	in	ADP
admet-881	69	30	the	the	DET
admet-881	69	31	mucus	mucus	NOUN
admet-881	69	32	layer	layer	NOUN
admet-881	70	1	[	[	X
admet-881	70	2	31	31	NUM
admet-881	70	3	]	]	PUNCT
admet-881	70	4	.	.	PUNCT
admet-881	71	1	there	there	PRON
admet-881	71	2	are	be	VERB
admet-881	71	3	even	even	ADV
admet-881	71	4	strategies	strategy	NOUN
admet-881	71	5	in	in	ADP
admet-881	71	6	which	which	PRON
admet-881	71	7	nanoparticles	nanoparticle	NOUN
admet-881	71	8	may	may	AUX
admet-881	71	9	increase	increase	VERB
admet-881	71	10	absorption	absorption	NOUN
admet-881	71	11	of	of	ADP
admet-881	71	12	low	low	ADJ
admet-881	71	13	permeability	permeability	NOUN
admet-881	71	14	compounds	compound	VERB
admet-881	71	15	through	through	ADP
admet-881	71	16	increased	increase	VERB
admet-881	71	17	transepithelial	transepithelial	ADJ
admet-881	71	18	transport	transport	NOUN
admet-881	71	19	[	[	X
admet-881	71	20	32	32	NUM
admet-881	71	21	]	]	PUNCT
admet-881	71	22	.	.	PUNCT
admet-881	72	1	obviously	obviously	ADV
admet-881	72	2	,	,	PUNCT
admet-881	72	3	more	more	ADJ
admet-881	72	4	formulation	formulation	NOUN
admet-881	72	5	research	research	NOUN
admet-881	72	6	and	and	CCONJ
admet-881	72	7	development	development	NOUN
admet-881	72	8	beyond	beyond	ADP
admet-881	72	9	the	the	DET
admet-881	72	10	established	establish	VERB
admet-881	72	11	pharmaceutical	pharmaceutical	NOUN
admet-881	72	12	strategies	strategy	NOUN
admet-881	72	13	are	be	AUX
admet-881	72	14	needed	need	VERB
admet-881	72	15	,	,	PUNCT
admet-881	72	16	to	to	PART
admet-881	72	17	better	well	ADV
admet-881	72	18	understand	understand	VERB
admet-881	72	19	the	the	DET
admet-881	72	20	mechanisms	mechanism	NOUN
admet-881	72	21	,	,	PUNCT
admet-881	72	22	physiological	physiological	ADJ
admet-881	72	23	possibilities	possibility	NOUN
admet-881	72	24	,	,	PUNCT
admet-881	72	25	and	and	CCONJ
admet-881	72	26	limitations	limitation	NOUN
admet-881	72	27	in	in	ADP
admet-881	72	28	the	the	DET
admet-881	72	29	in	in	ADJ
admet-881	72	30	vivo	vivo	NOUN
admet-881	72	31	gi	gi	NOUN
admet-881	72	32	absorption	absorption	NOUN
admet-881	72	33	of	of	ADP
admet-881	72	34	orally	orally	ADV
admet-881	72	35	administered	administer	VERB
admet-881	72	36	nanoparticles	nanoparticle	NOUN
admet-881	72	37	.	.	PUNCT
admet-881	73	1	this	this	DET
admet-881	73	2	review	review	NOUN
admet-881	73	3	focuses	focus	VERB
admet-881	73	4	on	on	ADP
admet-881	73	5	nanoparticle	nanoparticle	NOUN
admet-881	73	6	-	-	PUNCT
admet-881	73	7	based	base	VERB
admet-881	73	8	oral	oral	ADJ
admet-881	73	9	drug	drug	NOUN
admet-881	73	10	delivery	delivery	NOUN
admet-881	73	11	systems	system	NOUN
admet-881	73	12	and	and	CCONJ
admet-881	73	13	their	their	PRON
admet-881	73	14	in	in	ADP
admet-881	73	15	vivo	vivo	ADJ
admet-881	73	16	performance	performance	NOUN
admet-881	73	17	based	base	VERB
admet-881	73	18	on	on	ADP
admet-881	73	19	experimental	experimental	ADJ
admet-881	73	20	studies	study	NOUN
admet-881	73	21	in	in	ADP
admet-881	73	22	single	single	ADJ
admet-881	73	23	-	-	PUNCT
admet-881	73	24	pass	pass	ADJ
admet-881	73	25	intestinal	intestinal	ADJ
admet-881	73	26	perfusion	perfusion	NOUN
admet-881	73	27	(	(	PUNCT
admet-881	73	28	spip	spip	NOUN
admet-881	73	29	)	)	PUNCT
admet-881	73	30	models	model	NOUN
admet-881	73	31	.	.	PUNCT
admet-881	74	1	in	in	ADP
admet-881	74	2	particular	particular	ADJ
admet-881	74	3	,	,	PUNCT
admet-881	74	4	the	the	DET
admet-881	74	5	intestinal	intestinal	ADJ
admet-881	74	6	absorption	absorption	NOUN
admet-881	74	7	mechanisms	mechanism	NOUN
admet-881	74	8	will	will	AUX
admet-881	74	9	be	be	AUX
admet-881	74	10	discussed	discuss	VERB
admet-881	74	11	.	.	PUNCT
admet-881	75	1	these	these	DET
admet-881	75	2	data	datum	NOUN
admet-881	75	3	may	may	AUX
admet-881	75	4	contribute	contribute	VERB
admet-881	75	5	to	to	ADP
admet-881	75	6	a	a	DET
admet-881	75	7	future	future	ADJ
admet-881	75	8	framework	framework	NOUN
admet-881	75	9	for	for	ADP
admet-881	75	10	enabling	enable	VERB
admet-881	75	11	oral	oral	ADJ
admet-881	75	12	formulation	formulation	NOUN
admet-881	75	13	strategies	strategy	NOUN
admet-881	75	14	for	for	ADP
admet-881	75	15	mainly	mainly	ADV
admet-881	75	16	bcs	bcs	NOUN
admet-881	75	17	class	class	NOUN
admet-881	75	18	ii	ii	NOUN
admet-881	75	19	drugs	drug	NOUN
admet-881	75	20	.	.	PUNCT
admet-881	76	1	this	this	DET
admet-881	76	2	review	review	NOUN
admet-881	76	3	looks	look	VERB
admet-881	76	4	at	at	ADP
admet-881	76	5	the	the	DET
admet-881	76	6	role	role	NOUN
admet-881	76	7	of	of	ADP
admet-881	76	8	nanoparticles	nanoparticle	NOUN
admet-881	76	9	of	of	ADP
admet-881	76	10	four	four	NUM
admet-881	76	11	low	low	ADJ
admet-881	76	12	solubility	solubility	NOUN
admet-881	76	13	-	-	PUNCT
admet-881	76	14	high	high	ADJ
admet-881	76	15	permeability	permeability	NOUN
admet-881	76	16	drugs	drug	NOUN
admet-881	76	17	:	:	PUNCT
admet-881	76	18	aprepitant	aprepitant	ADJ
admet-881	76	19	,	,	PUNCT
admet-881	76	20	fenofibrate	fenofibrate	NOUN
admet-881	76	21	,	,	PUNCT
admet-881	76	22	cyclosporine	cyclosporine	NOUN
admet-881	76	23	,	,	PUNCT
admet-881	76	24	and	and	CCONJ
admet-881	76	25	danazol	danazol	ADJ
admet-881	76	26	.	.	PUNCT
admet-881	77	1	a	a	DET
admet-881	77	2	summary	summary	NOUN
admet-881	77	3	of	of	ADP
admet-881	77	4	data	datum	NOUN
admet-881	77	5	from	from	ADP
admet-881	77	6	both	both	PRON
admet-881	77	7	fasted	fast	VERB
admet-881	77	8	and	and	CCONJ
admet-881	77	9	fed	feed	VERB
admet-881	77	10	simulated	simulate	VERB
admet-881	77	11	conditions	condition	NOUN
admet-881	77	12	is	be	AUX
admet-881	77	13	included	include	VERB
admet-881	77	14	,	,	PUNCT
admet-881	77	15	because	because	SCONJ
admet-881	77	16	prandial	prandial	ADJ
admet-881	77	17	state	state	NOUN
admet-881	77	18	has	have	VERB
admet-881	77	19	a	a	DET
admet-881	77	20	strong	strong	ADJ
admet-881	77	21	effect	effect	NOUN
admet-881	77	22	on	on	ADP
admet-881	77	23	rate	rate	NOUN
admet-881	77	24	and	and	CCONJ
admet-881	77	25	extent	extent	NOUN
admet-881	77	26	of	of	ADP
admet-881	77	27	intestinal	intestinal	ADJ
admet-881	77	28	drug	drug	NOUN
admet-881	77	29	absorption	absorption	NOUN
admet-881	77	30	for	for	ADP
admet-881	77	31	some	some	DET
admet-881	77	32	drug	drug	NOUN
admet-881	77	33	products	product	NOUN
admet-881	77	34	.	.	PUNCT
admet-881	78	1	prandial	prandial	ADJ
admet-881	78	2	state	state	NOUN
admet-881	78	3	also	also	ADV
admet-881	78	4	illustrates	illustrate	VERB
admet-881	78	5	some	some	PRON
admet-881	78	6	of	of	ADP
admet-881	78	7	the	the	DET
admet-881	78	8	different	different	ADJ
admet-881	78	9	intraluminal	intraluminal	ADJ
admet-881	78	10	dissolution	dissolution	NOUN
admet-881	78	11	and	and	CCONJ
admet-881	78	12	absorption	absorption	NOUN
admet-881	78	13	mechanisms	mechanism	NOUN
admet-881	78	14	that	that	PRON
admet-881	78	15	come	come	VERB
admet-881	78	16	into	into	ADP
admet-881	78	17	play	play	NOUN
admet-881	78	18	.	.	PUNCT
admet-881	79	1	intraluminal	intraluminal	ADJ
admet-881	79	2	transport	transport	NOUN
admet-881	79	3	of	of	ADP
admet-881	79	4	nanoparticles	nanoparticle	NOUN
admet-881	79	5	and	and	CCONJ
admet-881	79	6	drugs	drug	NOUN
admet-881	79	7	in	in	ADP
admet-881	79	8	the	the	DET
admet-881	79	9	intestine	intestine	NOUN
admet-881	79	10	pharmaceutical	pharmaceutical	ADJ
admet-881	79	11	development	development	NOUN
admet-881	79	12	of	of	ADP
admet-881	79	13	oral	oral	ADJ
admet-881	79	14	drug	drug	NOUN
admet-881	79	15	delivery	delivery	NOUN
admet-881	79	16	systems	system	NOUN
admet-881	79	17	for	for	ADP
admet-881	79	18	low	low	ADJ
admet-881	79	19	solubility	solubility	NOUN
admet-881	79	20	drugs	drug	NOUN
admet-881	79	21	frequently	frequently	ADV
admet-881	79	22	uses	use	VERB
admet-881	79	23	particle	particle	NOUN
admet-881	79	24	size	size	NOUN
admet-881	79	25	reduction	reduction	NOUN
admet-881	79	26	as	as	ADP
admet-881	79	27	a	a	DET
admet-881	79	28	formulation	formulation	NOUN
admet-881	79	29	method	method	NOUN
admet-881	79	30	.	.	PUNCT
admet-881	80	1	development	development	NOUN
admet-881	80	2	of	of	ADP
admet-881	80	3	particle	particle	NOUN
admet-881	80	4	sizes	size	NOUN
admet-881	80	5	in	in	ADP
admet-881	80	6	the	the	DET
admet-881	80	7	nano	nano	NOUN
admet-881	80	8	-	-	PUNCT
admet-881	80	9	range	range	NOUN
admet-881	80	10	(	(	PUNCT
admet-881	80	11	diameter	diameter	NOUN
admet-881	80	12	<	<	X
admet-881	80	13	1000	1000	NUM
admet-881	80	14	nm	nm	NOUN
admet-881	80	15	)	)	PUNCT
admet-881	80	16	for	for	ADP
admet-881	80	17	oral	oral	ADJ
admet-881	80	18	products	product	NOUN
admet-881	80	19	has	have	AUX
admet-881	80	20	increased	increase	VERB
admet-881	80	21	as	as	ADP
admet-881	80	22	a	a	DET
admet-881	80	23	result	result	NOUN
admet-881	80	24	of	of	ADP
admet-881	80	25	improvements	improvement	NOUN
admet-881	80	26	in	in	ADP
admet-881	80	27	pharmaceutical	pharmaceutical	NOUN
admet-881	80	28	processing	processing	NOUN
admet-881	80	29	and	and	CCONJ
admet-881	80	30	manufacturing	manufacturing	NOUN
admet-881	80	31	[	[	X
admet-881	80	32	33	33	NUM
admet-881	80	33	]	]	PUNCT
admet-881	80	34	.	.	PUNCT
admet-881	81	1	as	as	SCONJ
admet-881	81	2	discussed	discuss	VERB
admet-881	81	3	above	above	ADV
admet-881	81	4	,	,	PUNCT
admet-881	81	5	oral	oral	ADJ
admet-881	81	6	nanosuspensions	nanosuspension	NOUN
admet-881	81	7	dissolve	dissolve	VERB
admet-881	81	8	faster	fast	ADV
admet-881	81	9	than	than	ADP
admet-881	81	10	microsuspensions	microsuspension	NOUN
admet-881	81	11	,	,	PUNCT
admet-881	81	12	and	and	CCONJ
admet-881	81	13	accordingly	accordingly	ADV
admet-881	81	14	increase	increase	VERB
admet-881	81	15	intestinal	intestinal	ADJ
admet-881	81	16	absorption	absorption	NOUN
admet-881	81	17	and	and	CCONJ
admet-881	81	18	bioavailability	bioavailability	NOUN
admet-881	81	19	of	of	ADP
admet-881	81	20	bcs	bcs	NOUN
admet-881	81	21	ii	ii	PROPN
admet-881	81	22	compounds	compound	VERB
admet-881	81	23	[	[	X
admet-881	81	24	28,34	28,34	NUM
admet-881	81	25	-	-	SYM
admet-881	81	26	37	37	NUM
admet-881	81	27	]	]	PUNCT
admet-881	81	28	.	.	PUNCT
admet-881	82	1	theoretically	theoretically	ADV
admet-881	82	2	,	,	PUNCT
admet-881	82	3	admet	admet	PROPN
admet-881	82	4	&	&	CCONJ
admet-881	82	5	dmpk	dmpk	PROPN
admet-881	82	6	8(4	8(4	NOUN
admet-881	82	7	)	)	PUNCT
admet-881	82	8	(	(	PUNCT
admet-881	82	9	2020	2020	NUM
admet-881	82	10	)	)	PUNCT
admet-881	82	11	375	375	NUM
admet-881	82	12	-	-	SYM
admet-881	82	13	390	390	NUM
admet-881	82	14	intestinal	intestinal	ADJ
admet-881	82	15	absorption	absorption	NOUN
admet-881	82	16	of	of	ADP
admet-881	82	17	bcs	bcs	NOUN
admet-881	82	18	class	class	NOUN
admet-881	82	19	ii	ii	PROPN
admet-881	82	20	drugs	drug	NOUN
admet-881	82	21	nanoparticles	nanoparticle	NOUN
admet-881	82	22	doi	doi	NOUN
admet-881	82	23	:	:	PUNCT
admet-881	82	24	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	82	25	379	379	NUM
admet-881	82	26	api	api	NOUN
admet-881	82	27	particle	particle	NOUN
admet-881	82	28	size	size	NOUN
admet-881	82	29	reduction	reduction	NOUN
admet-881	82	30	reaches	reach	VERB
admet-881	82	31	a	a	DET
admet-881	82	32	point	point	NOUN
admet-881	82	33	at	at	ADP
admet-881	82	34	which	which	PRON
admet-881	82	35	dissolution	dissolution	NOUN
admet-881	82	36	is	be	AUX
admet-881	82	37	no	no	PRON
admet-881	82	38	the	the	ADV
admet-881	82	39	longer	long	ADJ
admet-881	82	40	the	the	DET
admet-881	82	41	rate	rate	NOUN
admet-881	82	42	-	-	PUNCT
admet-881	82	43	limiting	limit	VERB
admet-881	82	44	step	step	NOUN
admet-881	82	45	in	in	ADV
admet-881	82	46	in	in	ADP
admet-881	82	47	vivo	vivo	NOUN
admet-881	82	48	absorption	absorption	NOUN
admet-881	82	49	.	.	PUNCT
admet-881	83	1	at	at	ADP
admet-881	83	2	that	that	DET
admet-881	83	3	point	point	NOUN
admet-881	83	4	,	,	PUNCT
admet-881	83	5	further	further	ADJ
admet-881	83	6	size	size	NOUN
admet-881	83	7	reduction	reduction	NOUN
admet-881	83	8	is	be	AUX
admet-881	83	9	not	not	PART
admet-881	83	10	expected	expect	VERB
admet-881	83	11	to	to	PART
admet-881	83	12	increase	increase	VERB
admet-881	83	13	intestinal	intestinal	ADJ
admet-881	83	14	absorption	absorption	NOUN
admet-881	83	15	as	as	SCONJ
admet-881	83	16	it	it	PRON
admet-881	83	17	has	have	AUX
admet-881	83	18	become	become	VERB
admet-881	83	19	solubility	solubility	NOUN
admet-881	83	20	controlled	control	VERB
admet-881	83	21	[	[	X
admet-881	83	22	8	8	NUM
admet-881	83	23	]	]	PUNCT
admet-881	83	24	.	.	PUNCT
admet-881	84	1	however	however	ADV
admet-881	84	2	,	,	PUNCT
admet-881	84	3	experimental	experimental	ADJ
admet-881	84	4	observations	observation	NOUN
admet-881	84	5	indicate	indicate	VERB
admet-881	84	6	otherwise	otherwise	ADV
admet-881	84	7	.	.	PUNCT
admet-881	85	1	absorption	absorption	NOUN
admet-881	85	2	rates	rate	NOUN
admet-881	85	3	continue	continue	VERB
admet-881	85	4	to	to	PART
admet-881	85	5	increase	increase	VERB
admet-881	85	6	with	with	ADP
admet-881	85	7	decreasing	decrease	VERB
admet-881	85	8	particle	particle	NOUN
admet-881	85	9	size	size	NOUN
admet-881	85	10	,	,	PUNCT
admet-881	85	11	which	which	PRON
admet-881	85	12	suggests	suggest	VERB
admet-881	85	13	that	that	SCONJ
admet-881	85	14	additional	additional	ADJ
admet-881	85	15	absorptionpromoting	absorptionpromote	VERB
admet-881	85	16	intestinal	intestinal	ADJ
admet-881	85	17	processes	process	NOUN
admet-881	85	18	are	be	AUX
admet-881	85	19	taking	take	VERB
admet-881	85	20	place	place	NOUN
admet-881	85	21	simultaneously	simultaneously	ADV
admet-881	85	22	[	[	X
admet-881	85	23	29,38,39	29,38,39	NUM
admet-881	85	24	]	]	PUNCT
admet-881	85	25	.	.	PUNCT
admet-881	86	1	it	it	PRON
admet-881	86	2	has	have	AUX
admet-881	86	3	been	be	AUX
admet-881	86	4	proposed	propose	VERB
admet-881	86	5	that	that	SCONJ
admet-881	86	6	nanoparticles	nanoparticle	NOUN
admet-881	86	7	are	be	AUX
admet-881	86	8	crossing	cross	VERB
admet-881	86	9	the	the	DET
admet-881	86	10	epithelial	epithelial	ADJ
admet-881	86	11	mucus	mucus	NOUN
admet-881	86	12	layer	layer	NOUN
admet-881	86	13	to	to	ADP
admet-881	86	14	a	a	DET
admet-881	86	15	greater	great	ADJ
admet-881	86	16	extent	extent	NOUN
admet-881	86	17	than	than	ADP
admet-881	86	18	larger	large	ADJ
admet-881	86	19	particles	particle	NOUN
admet-881	86	20	[	[	X
admet-881	86	21	40	40	NUM
admet-881	86	22	]	]	PUNCT
admet-881	86	23	.	.	PUNCT
admet-881	87	1	mucus	mucus	NOUN
admet-881	87	2	is	be	AUX
admet-881	87	3	predominately	predominately	ADV
admet-881	87	4	comprised	comprise	VERB
admet-881	87	5	of	of	ADP
admet-881	87	6	the	the	DET
admet-881	87	7	glycoprotein	glycoprotein	NOUN
admet-881	87	8	mucin	mucin	NOUN
admet-881	87	9	and	and	CCONJ
admet-881	87	10	water	water	NOUN
admet-881	87	11	.	.	PUNCT
admet-881	88	1	this	this	PRON
admet-881	88	2	gives	give	VERB
admet-881	88	3	it	it	PRON
admet-881	88	4	hydrophilic	hydrophilic	ADJ
admet-881	88	5	and	and	CCONJ
admet-881	88	6	hydrophobic	hydrophobic	NOUN
admet-881	88	7	domains	domain	NOUN
admet-881	88	8	,	,	PUNCT
admet-881	88	9	a	a	DET
admet-881	88	10	negative	negative	ADJ
admet-881	88	11	net	net	ADJ
admet-881	88	12	charge	charge	NOUN
admet-881	88	13	,	,	PUNCT
admet-881	88	14	and	and	CCONJ
admet-881	88	15	high	high	ADJ
admet-881	88	16	porosity	porosity	NOUN
admet-881	88	17	and	and	CCONJ
admet-881	88	18	pore	pore	ADJ
admet-881	88	19	interconnectivity	interconnectivity	NOUN
admet-881	88	20	.	.	PUNCT
admet-881	89	1	in	in	ADP
admet-881	89	2	addition	addition	NOUN
admet-881	89	3	,	,	PUNCT
admet-881	89	4	mucus	mucus	NOUN
admet-881	89	5	is	be	AUX
admet-881	89	6	a	a	DET
admet-881	89	7	dynamic	dynamic	ADJ
admet-881	89	8	,	,	PUNCT
admet-881	89	9	semipermeable	semipermeable	NOUN
admet-881	89	10	transport	transport	NOUN
admet-881	89	11	barrier	barrier	NOUN
admet-881	89	12	that	that	PRON
admet-881	89	13	is	be	AUX
admet-881	89	14	continuously	continuously	ADV
admet-881	89	15	secreted	secrete	VERB
admet-881	89	16	,	,	PUNCT
admet-881	89	17	shed	shed	ADJ
admet-881	89	18	,	,	PUNCT
admet-881	89	19	and	and	CCONJ
admet-881	89	20	digested	digest	VERB
admet-881	89	21	.	.	PUNCT
admet-881	90	1	mucus	mucus	NOUN
admet-881	90	2	thickness	thickness	NOUN
admet-881	90	3	is	be	AUX
admet-881	90	4	about	about	ADV
admet-881	90	5	120	120	NUM
admet-881	90	6	μm	μm	NUM
admet-881	90	7	,	,	PUNCT
admet-881	90	8	480	480	NUM
admet-881	90	9	μm	μm	NUM
admet-881	90	10	and	and	CCONJ
admet-881	90	11	830	830	NUM
admet-881	90	12	μm	μm	NOUN
admet-881	90	13	in	in	ADP
admet-881	90	14	the	the	DET
admet-881	90	15	jejunum	jejunum	NOUN
admet-881	90	16	,	,	PUNCT
admet-881	90	17	ileum	ileum	NOUN
admet-881	90	18	and	and	CCONJ
admet-881	90	19	colon	colon	NOUN
admet-881	90	20	,	,	PUNCT
admet-881	90	21	respectively	respectively	ADV
admet-881	90	22	,	,	PUNCT
admet-881	90	23	with	with	ADP
admet-881	90	24	a	a	DET
admet-881	90	25	turnover	turnover	NOUN
admet-881	90	26	time	time	NOUN
admet-881	90	27	of	of	ADP
admet-881	90	28	a	a	DET
admet-881	90	29	few	few	ADJ
admet-881	90	30	hours	hour	NOUN
admet-881	90	31	[	[	X
admet-881	90	32	41,42	41,42	NOUN
admet-881	90	33	]	]	X
admet-881	90	34	.	.	PUNCT
admet-881	91	1	the	the	DET
admet-881	91	2	small	small	ADJ
admet-881	91	3	intestinal	intestinal	ADJ
admet-881	91	4	mucus	mucus	NOUN
admet-881	91	5	contains	contain	VERB
admet-881	91	6	a	a	DET
admet-881	91	7	single	single	ADJ
admet-881	91	8	mucus	mucus	NOUN
admet-881	91	9	layer	layer	NOUN
admet-881	91	10	that	that	PRON
admet-881	91	11	is	be	AUX
admet-881	91	12	not	not	PART
admet-881	91	13	a	a	DET
admet-881	91	14	rate	rate	NOUN
admet-881	91	15	-	-	PUNCT
admet-881	91	16	limiting	limit	VERB
admet-881	91	17	step	step	NOUN
admet-881	91	18	in	in	ADP
admet-881	91	19	the	the	DET
admet-881	91	20	absorption	absorption	NOUN
admet-881	91	21	,	,	PUNCT
admet-881	91	22	not	not	PART
admet-881	91	23	even	even	ADV
admet-881	91	24	for	for	ADP
admet-881	91	25	lipophilic	lipophilic	ADJ
admet-881	91	26	high	high	ADJ
admet-881	91	27	-	-	PUNCT
admet-881	91	28	permeability	permeability	NOUN
admet-881	91	29	drugs	drug	NOUN
admet-881	91	30	and/or	and/or	CCONJ
admet-881	91	31	high	high	ADJ
admet-881	91	32	permeability	permeability	NOUN
admet-881	91	33	drugs	drug	NOUN
admet-881	91	34	transported	transport	VERB
admet-881	91	35	by	by	ADP
admet-881	91	36	an	an	DET
admet-881	91	37	efficient	efficient	ADJ
admet-881	91	38	carrier	carrier	NOUN
admet-881	91	39	-	-	PUNCT
admet-881	91	40	mediated	mediate	VERB
admet-881	91	41	(	(	PUNCT
admet-881	91	42	cm	cm	NOUN
admet-881	91	43	)	)	PUNCT
admet-881	91	44	transport	transport	NOUN
admet-881	91	45	route	route	NOUN
admet-881	91	46	[	[	X
admet-881	91	47	43	43	NUM
admet-881	91	48	-	-	SYM
admet-881	91	49	45	45	NUM
admet-881	91	50	]	]	PUNCT
admet-881	91	51	.	.	PUNCT
admet-881	92	1	based	base	VERB
admet-881	92	2	on	on	ADP
admet-881	92	3	in	in	ADP
admet-881	92	4	vivo	vivo	ADJ
admet-881	92	5	jejunal	jejunal	ADJ
admet-881	92	6	perfusion	perfusion	NOUN
admet-881	92	7	at	at	ADP
admet-881	92	8	different	different	ADJ
admet-881	92	9	rates	rate	NOUN
admet-881	92	10	in	in	ADP
admet-881	92	11	humans	human	NOUN
admet-881	92	12	,	,	PUNCT
admet-881	92	13	the	the	DET
admet-881	92	14	resistance	resistance	NOUN
admet-881	92	15	of	of	ADP
admet-881	92	16	the	the	DET
admet-881	92	17	mucus	mucus	NOUN
admet-881	92	18	layer	layer	NOUN
admet-881	92	19	to	to	ADP
admet-881	92	20	the	the	DET
admet-881	92	21	intestinal	intestinal	ADJ
admet-881	92	22	absorption	absorption	NOUN
admet-881	92	23	of	of	ADP
admet-881	92	24	highly	highly	ADV
admet-881	92	25	permeable	permeable	ADJ
admet-881	92	26	solutes	solute	NOUN
admet-881	92	27	is	be	AUX
admet-881	92	28	markedly	markedly	ADV
admet-881	92	29	overestimated	overestimate	VERB
admet-881	92	30	.	.	PUNCT
admet-881	93	1	instead	instead	ADV
admet-881	93	2	,	,	PUNCT
admet-881	93	3	intestinal	intestinal	ADJ
admet-881	93	4	absorption	absorption	NOUN
admet-881	93	5	in	in	ADP
admet-881	93	6	humans	human	NOUN
admet-881	93	7	seems	seem	VERB
admet-881	93	8	to	to	PART
admet-881	93	9	be	be	AUX
admet-881	93	10	membrane	membrane	NOUN
admet-881	93	11	controlled	control	VERB
admet-881	93	12	for	for	ADP
admet-881	93	13	both	both	CCONJ
admet-881	93	14	lowand	lowand	ADJ
admet-881	93	15	high	high	ADJ
admet-881	93	16	-	-	PUNCT
admet-881	93	17	permeability	permeability	NOUN
admet-881	93	18	compounds	compound	NOUN
admet-881	93	19	,	,	PUNCT
admet-881	93	20	irrespective	irrespective	ADV
admet-881	93	21	of	of	ADP
admet-881	93	22	transport	transport	NOUN
admet-881	93	23	mechanism	mechanism	NOUN
admet-881	93	24	[	[	X
admet-881	93	25	46	46	NUM
admet-881	93	26	]	]	PUNCT
admet-881	93	27	.	.	PUNCT
admet-881	94	1	it	it	PRON
admet-881	94	2	is	be	AUX
admet-881	94	3	well	well	ADV
admet-881	94	4	-	-	PUNCT
admet-881	94	5	recognized	recognize	VERB
admet-881	94	6	that	that	SCONJ
admet-881	94	7	nanoparticles	nanoparticle	NOUN
admet-881	94	8	interact	interact	VERB
admet-881	94	9	with	with	ADP
admet-881	94	10	mucus	mucus	NOUN
admet-881	94	11	by	by	ADP
admet-881	94	12	different	different	ADJ
admet-881	94	13	mechanisms	mechanism	NOUN
admet-881	94	14	and	and	CCONJ
admet-881	94	15	that	that	SCONJ
admet-881	94	16	nanoparticles	nanoparticle	NOUN
admet-881	94	17	may	may	AUX
admet-881	94	18	acquire	acquire	VERB
admet-881	94	19	different	different	ADJ
admet-881	94	20	biological	biological	ADJ
admet-881	94	21	and	and	CCONJ
admet-881	94	22	physicochemical	physicochemical	ADJ
admet-881	94	23	properties	property	NOUN
admet-881	94	24	as	as	ADP
admet-881	94	25	a	a	DET
admet-881	94	26	consequence	consequence	NOUN
admet-881	94	27	of	of	ADP
admet-881	94	28	adsorption	adsorption	NOUN
admet-881	94	29	of	of	ADP
admet-881	94	30	intraluminal	intraluminal	ADJ
admet-881	94	31	gi	gi	NOUN
admet-881	94	32	biomolecules	biomolecule	NOUN
admet-881	94	33	to	to	ADP
admet-881	94	34	their	their	PRON
admet-881	94	35	surface	surface	NOUN
admet-881	94	36	(	(	PUNCT
admet-881	94	37	i.e.	i.e.	X
admet-881	94	38	,	,	PUNCT
admet-881	94	39	corona	corona	NOUN
admet-881	94	40	formation	formation	NOUN
admet-881	94	41	)	)	PUNCT
admet-881	94	42	.	.	PUNCT
admet-881	95	1	commercially	commercially	ADV
admet-881	95	2	available	available	ADJ
admet-881	95	3	oral	oral	ADJ
admet-881	95	4	nanoparticles	nanoparticle	NOUN
admet-881	95	5	are	be	AUX
admet-881	95	6	typically	typically	ADV
admet-881	95	7	around	around	ADP
admet-881	95	8	100–300	100–300	NUM
admet-881	95	9	nm	nm	NOUN
admet-881	95	10	,	,	PUNCT
admet-881	95	11	which	which	PRON
admet-881	95	12	should	should	AUX
admet-881	95	13	allow	allow	VERB
admet-881	95	14	them	they	PRON
admet-881	95	15	to	to	PART
admet-881	95	16	pass	pass	VERB
admet-881	95	17	faster	fast	ADV
admet-881	95	18	than	than	SCONJ
admet-881	95	19	larger	large	ADJ
admet-881	95	20	api	api	NOUN
admet-881	95	21	particles	particle	NOUN
admet-881	95	22	across	across	ADP
admet-881	95	23	the	the	DET
admet-881	95	24	gel	gel	NOUN
admet-881	95	25	-	-	PUNCT
admet-881	95	26	like	like	ADJ
admet-881	95	27	,	,	PUNCT
admet-881	95	28	mucin	mucin	NOUN
admet-881	95	29	-	-	PUNCT
admet-881	95	30	based	base	VERB
admet-881	95	31	mesh	mesh	NOUN
admet-881	95	32	structure	structure	NOUN
admet-881	95	33	composing	compose	VERB
admet-881	95	34	the	the	DET
admet-881	95	35	mucus	mucus	NOUN
admet-881	95	36	layer	layer	NOUN
admet-881	95	37	.	.	PUNCT
admet-881	96	1	a	a	DET
admet-881	96	2	continuous	continuous	ADJ
admet-881	96	3	mucus	mucus	NOUN
admet-881	96	4	layer	layer	NOUN
admet-881	96	5	exists	exist	VERB
admet-881	96	6	throughout	throughout	ADP
admet-881	96	7	the	the	DET
admet-881	96	8	small	small	ADJ
admet-881	96	9	intestine	intestine	NOUN
admet-881	96	10	,	,	PUNCT
admet-881	96	11	and	and	CCONJ
admet-881	96	12	is	be	AUX
admet-881	96	13	highly	highly	ADV
admet-881	96	14	stratified	stratify	VERB
admet-881	96	15	adjacent	adjacent	ADJ
admet-881	96	16	to	to	ADP
admet-881	96	17	the	the	DET
admet-881	96	18	epithelium	epithelium	NOUN
admet-881	96	19	.	.	PUNCT
admet-881	97	1	experiments	experiment	NOUN
admet-881	97	2	show	show	VERB
admet-881	97	3	that	that	SCONJ
admet-881	97	4	mucin	mucin	NOUN
admet-881	97	5	pore	pore	ADJ
admet-881	97	6	size	size	NOUN
admet-881	97	7	is	be	AUX
admet-881	97	8	consistent	consistent	ADJ
admet-881	97	9	with	with	ADP
admet-881	97	10	free	free	ADJ
admet-881	97	11	diffusion	diffusion	NOUN
admet-881	97	12	of	of	ADP
admet-881	97	13	100	100	NUM
admet-881	97	14	nm	nm	ADJ
admet-881	97	15	particles	particle	NOUN
admet-881	97	16	,	,	PUNCT
admet-881	97	17	but	but	CCONJ
admet-881	97	18	limited	limited	ADJ
admet-881	97	19	diffusion	diffusion	NOUN
admet-881	97	20	of	of	ADP
admet-881	97	21	500	500	NUM
admet-881	97	22	nm	nm	ADJ
admet-881	97	23	particles	particle	NOUN
admet-881	97	24	[	[	X
admet-881	97	25	40,47	40,47	X
admet-881	97	26	]	]	X
admet-881	97	27	.	.	PUNCT
admet-881	98	1	this	this	PRON
admet-881	98	2	is	be	AUX
admet-881	98	3	due	due	ADJ
admet-881	98	4	to	to	ADP
admet-881	98	5	increased	increase	VERB
admet-881	98	6	diffusivity	diffusivity	NOUN
admet-881	98	7	for	for	ADP
admet-881	98	8	a	a	DET
admet-881	98	9	spherical	spherical	ADJ
admet-881	98	10	particle	particle	NOUN
admet-881	98	11	with	with	ADP
admet-881	98	12	smaller	small	ADJ
admet-881	98	13	radius	radius	NOUN
admet-881	98	14	,	,	PUNCT
admet-881	98	15	which	which	PRON
admet-881	98	16	then	then	ADV
admet-881	98	17	establishes	establish	VERB
admet-881	98	18	a	a	DET
admet-881	98	19	high	high	ADJ
admet-881	98	20	local	local	ADJ
admet-881	98	21	drug	drug	NOUN
admet-881	98	22	concentration	concentration	NOUN
admet-881	98	23	available	available	ADJ
admet-881	98	24	for	for	ADP
admet-881	98	25	permeation	permeation	NOUN
admet-881	98	26	adjacent	adjacent	ADJ
admet-881	98	27	to	to	ADP
admet-881	98	28	the	the	DET
admet-881	98	29	apical	apical	ADJ
admet-881	98	30	enterocyte	enterocyte	NOUN
admet-881	98	31	membrane	membrane	NOUN
admet-881	99	1	[	[	X
admet-881	99	2	31,48	31,48	NOUN
admet-881	99	3	]	]	PUNCT
admet-881	99	4	.	.	PUNCT
admet-881	100	1	the	the	DET
admet-881	100	2	primary	primary	ADJ
admet-881	100	3	mechanism	mechanism	NOUN
admet-881	100	4	of	of	ADP
admet-881	100	5	transport	transport	NOUN
admet-881	100	6	through	through	ADP
admet-881	100	7	this	this	DET
admet-881	100	8	layer	layer	NOUN
admet-881	100	9	is	be	AUX
admet-881	100	10	diffusion	diffusion	NOUN
admet-881	100	11	,	,	PUNCT
admet-881	100	12	as	as	SCONJ
admet-881	100	13	opposed	oppose	VERB
admet-881	100	14	to	to	ADP
admet-881	100	15	the	the	DET
admet-881	100	16	intestinal	intestinal	ADJ
admet-881	100	17	lumen	luman	NOUN
admet-881	100	18	,	,	PUNCT
admet-881	100	19	where	where	SCONJ
admet-881	100	20	the	the	DET
admet-881	100	21	primary	primary	ADJ
admet-881	100	22	transport	transport	NOUN
admet-881	100	23	mechanism	mechanism	NOUN
admet-881	100	24	is	be	AUX
admet-881	100	25	convection	convection	NOUN
admet-881	100	26	[	[	X
admet-881	100	27	49	49	NUM
admet-881	100	28	]	]	PUNCT
admet-881	100	29	.	.	PUNCT
admet-881	101	1	the	the	DET
admet-881	101	2	combined	combine	VERB
admet-881	101	3	effects	effect	NOUN
admet-881	101	4	of	of	ADP
admet-881	101	5	increased	increase	VERB
admet-881	101	6	dissolution	dissolution	NOUN
admet-881	101	7	,	,	PUNCT
admet-881	101	8	mucus	mucus	NOUN
admet-881	101	9	penetration	penetration	NOUN
admet-881	101	10	,	,	PUNCT
admet-881	101	11	and	and	CCONJ
admet-881	101	12	mucus	mucus	NOUN
admet-881	101	13	layer	layer	NOUN
admet-881	101	14	diffusivity	diffusivity	NOUN
admet-881	101	15	for	for	ADP
admet-881	101	16	small	small	ADJ
admet-881	101	17	particles	particle	NOUN
admet-881	101	18	seem	seem	VERB
admet-881	101	19	to	to	PART
admet-881	101	20	explain	explain	VERB
admet-881	101	21	the	the	DET
admet-881	101	22	increased	increase	VERB
admet-881	101	23	intestinal	intestinal	ADJ
admet-881	101	24	absorption	absorption	NOUN
admet-881	101	25	of	of	ADP
admet-881	101	26	nanoparticles	nanoparticle	NOUN
admet-881	101	27	compared	compare	VERB
admet-881	101	28	to	to	ADP
admet-881	101	29	larger	large	ADJ
admet-881	101	30	ones	one	NOUN
admet-881	101	31	.	.	PUNCT
admet-881	102	1	method	method	NOUN
admet-881	102	2	of	of	ADP
admet-881	102	3	in	in	ADP
admet-881	102	4	vivo	vivo	NOUN
admet-881	102	5	absorption	absorption	NOUN
admet-881	102	6	:	:	PUNCT
admet-881	102	7	single	single	ADJ
admet-881	102	8	-	-	PUNCT
admet-881	102	9	pass	pass	ADJ
admet-881	102	10	intestinal	intestinal	ADJ
admet-881	102	11	perfusion	perfusion	NOUN
admet-881	102	12	model	model	NOUN
admet-881	102	13	and	and	CCONJ
admet-881	102	14	absorption	absorption	NOUN
admet-881	102	15	calculations	calculation	NOUN
admet-881	102	16	this	this	DET
admet-881	102	17	review	review	NOUN
admet-881	102	18	discusses	discuss	VERB
admet-881	102	19	mainly	mainly	ADV
admet-881	102	20	data	datum	NOUN
admet-881	102	21	from	from	ADP
admet-881	102	22	the	the	DET
admet-881	102	23	rat	rat	NOUN
admet-881	102	24	and	and	CCONJ
admet-881	102	25	pig	pig	NOUN
admet-881	102	26	single	single	ADJ
admet-881	102	27	-	-	PUNCT
admet-881	102	28	pass	pass	ADJ
admet-881	102	29	intestinal	intestinal	ADJ
admet-881	102	30	perfusion	perfusion	NOUN
admet-881	102	31	(	(	PUNCT
admet-881	102	32	spip	spip	NOUN
admet-881	102	33	)	)	PUNCT
admet-881	102	34	models	model	NOUN
admet-881	102	35	in	in	ADP
admet-881	102	36	relation	relation	NOUN
admet-881	102	37	to	to	ADP
admet-881	102	38	other	other	ADJ
admet-881	102	39	relevant	relevant	ADJ
admet-881	102	40	in	in	ADP
admet-881	102	41	vivo	vivo	ADJ
admet-881	102	42	data	datum	NOUN
admet-881	103	1	[	[	X
admet-881	103	2	50	50	NUM
admet-881	103	3	-	-	SYM
admet-881	103	4	53	53	NUM
admet-881	103	5	]	]	PUNCT
admet-881	103	6	.	.	PUNCT
admet-881	104	1	the	the	DET
admet-881	104	2	spip	spip	PROPN
admet-881	104	3	model	model	NOUN
admet-881	104	4	has	have	AUX
admet-881	104	5	been	be	AUX
admet-881	104	6	extensively	extensively	ADV
admet-881	104	7	used	use	VERB
admet-881	104	8	in	in	ADP
admet-881	104	9	preclinical	preclinical	ADJ
admet-881	104	10	studies	study	NOUN
admet-881	104	11	to	to	PART
admet-881	104	12	investigate	investigate	VERB
admet-881	104	13	and	and	CCONJ
admet-881	104	14	determine	determine	VERB
admet-881	104	15	epithelial	epithelial	ADJ
admet-881	104	16	effective	effective	ADJ
admet-881	104	17	intestinal	intestinal	ADJ
admet-881	104	18	permeability	permeability	NOUN
admet-881	104	19	(	(	PUNCT
admet-881	104	20	peff	peff	PROPN
admet-881	104	21	)	)	PUNCT
admet-881	104	22	,	,	PUNCT
admet-881	104	23	as	as	ADV
admet-881	104	24	well	well	ADV
admet-881	104	25	as	as	ADP
admet-881	104	26	other	other	ADJ
admet-881	104	27	absorption	absorption	NOUN
admet-881	104	28	parameters	parameter	NOUN
admet-881	104	29	for	for	ADP
admet-881	104	30	drugs	drug	NOUN
admet-881	104	31	and	and	CCONJ
admet-881	104	32	drug	drug	NOUN
admet-881	104	33	delivery	delivery	NOUN
admet-881	104	34	systems	system	NOUN
admet-881	104	35	,	,	PUNCT
admet-881	104	36	such	such	ADJ
admet-881	104	37	as	as	ADP
admet-881	104	38	suspensions	suspension	NOUN
admet-881	104	39	and	and	CCONJ
admet-881	104	40	lipid	lipid	NOUN
admet-881	104	41	-	-	PUNCT
admet-881	104	42	based	base	VERB
admet-881	104	43	ones	one	NOUN
admet-881	104	44	(	(	PUNCT
admet-881	104	45	figure	figure	NOUN
admet-881	104	46	2	2	NUM
admet-881	104	47	)	)	PUNCT
admet-881	104	48	.	.	PUNCT
admet-881	105	1	intestinal	intestinal	ADJ
admet-881	105	2	peff	peff	PROPN
admet-881	105	3	,	,	PUNCT
admet-881	105	4	absorption	absorption	NOUN
admet-881	105	5	flux	flux	NOUN
admet-881	105	6	(	(	PUNCT
admet-881	105	7	japp	japp	ADJ
admet-881	105	8	)	)	PUNCT
admet-881	105	9	,	,	PUNCT
admet-881	105	10	and	and	CCONJ
admet-881	105	11	fraction	fraction	NOUN
admet-881	105	12	dose	dose	NOUN
admet-881	105	13	absorbed	absorb	VERB
admet-881	105	14	(	(	PUNCT
admet-881	105	15	fabs	fab	NOUN
admet-881	105	16	)	)	PUNCT
admet-881	105	17	are	be	AUX
admet-881	105	18	the	the	DET
admet-881	105	19	three	three	NUM
admet-881	105	20	key	key	ADJ
admet-881	105	21	biopharmaceutical	biopharmaceutical	ADJ
admet-881	105	22	variables	variable	NOUN
admet-881	105	23	that	that	PRON
admet-881	105	24	describe	describe	VERB
admet-881	105	25	the	the	DET
admet-881	105	26	absorption	absorption	NOUN
admet-881	105	27	and	and	CCONJ
admet-881	105	28	transport	transport	NOUN
admet-881	105	29	properties	property	NOUN
admet-881	105	30	of	of	ADP
admet-881	105	31	a	a	DET
admet-881	105	32	drug	drug	NOUN
admet-881	105	33	across	across	ADP
admet-881	105	34	the	the	DET
admet-881	105	35	intestinal	intestinal	ADJ
admet-881	105	36	barrier	barrier	NOUN
admet-881	105	37	in	in	ADP
admet-881	105	38	the	the	DET
admet-881	105	39	spip	spip	NOUN
admet-881	105	40	model	model	NOUN
admet-881	105	41	[	[	X
admet-881	105	42	3,54	3,54	NUM
admet-881	105	43	]	]	X
admet-881	105	44	.	.	PUNCT
admet-881	106	1	this	this	DET
admet-881	106	2	model	model	NOUN
admet-881	106	3	is	be	AUX
admet-881	106	4	used	use	VERB
admet-881	106	5	to	to	PART
admet-881	106	6	investigate	investigate	VERB
admet-881	106	7	oral	oral	ADJ
admet-881	106	8	drug	drug	NOUN
admet-881	106	9	delivery	delivery	NOUN
admet-881	106	10	and	and	CCONJ
admet-881	106	11	characterize	characterize	VERB
admet-881	106	12	pre	pre	NOUN
admet-881	106	13	-	-	NOUN
admet-881	106	14	formulations	formulation	NOUN
admet-881	106	15	,	,	PUNCT
admet-881	106	16	as	as	ADP
admet-881	106	17	part	part	NOUN
admet-881	106	18	of	of	ADP
admet-881	106	19	the	the	DET
admet-881	106	20	development	development	NOUN
admet-881	106	21	process	process	NOUN
admet-881	106	22	of	of	ADP
admet-881	106	23	a	a	DET
admet-881	106	24	pharmaceutical	pharmaceutical	ADJ
admet-881	106	25	product	product	NOUN
admet-881	106	26	.	.	PUNCT
admet-881	107	1	the	the	DET
admet-881	107	2	spip	spip	PROPN
admet-881	107	3	model	model	NOUN
admet-881	107	4	is	be	AUX
admet-881	107	5	also	also	ADV
admet-881	107	6	useful	useful	ADJ
admet-881	107	7	for	for	ADP
admet-881	107	8	investigating	investigate	VERB
admet-881	107	9	regional	regional	ADJ
admet-881	107	10	intestinal	intestinal	ADJ
admet-881	107	11	permeability	permeability	NOUN
admet-881	107	12	and	and	CCONJ
admet-881	107	13	transport	transport	NOUN
admet-881	107	14	mechanisms	mechanism	NOUN
admet-881	107	15	involved	involve	VERB
admet-881	107	16	during	during	ADP
admet-881	107	17	in	in	ADP
admet-881	107	18	vivo	vivo	ADJ
admet-881	107	19	–	–	PUNCT
admet-881	107	20	relevant	relevant	ADJ
admet-881	107	21	conditions	condition	NOUN
admet-881	107	22	,	,	PUNCT
admet-881	107	23	and	and	CCONJ
admet-881	107	24	for	for	ADP
admet-881	107	25	determining	determine	VERB
admet-881	107	26	the	the	DET
admet-881	107	27	bcs	bcs	NOUN
admet-881	107	28	classification	classification	NOUN
admet-881	107	29	of	of	ADP
admet-881	107	30	any	any	DET
admet-881	107	31	api	api	NOUN
admet-881	107	32	[	[	X
admet-881	107	33	54	54	NUM
admet-881	107	34	]	]	PUNCT
admet-881	107	35	.	.	PUNCT
admet-881	108	1	this	this	DET
admet-881	108	2	model	model	NOUN
admet-881	108	3	is	be	AUX
admet-881	108	4	also	also	ADV
admet-881	108	5	used	use	VERB
admet-881	108	6	to	to	PART
admet-881	108	7	investigate	investigate	VERB
admet-881	108	8	the	the	DET
admet-881	108	9	interplay	interplay	NOUN
admet-881	108	10	between	between	ADP
admet-881	108	11	in	in	ADP
admet-881	108	12	vivo	vivo	ADJ
admet-881	108	13	dissolution	dissolution	NOUN
admet-881	108	14	of	of	ADP
admet-881	108	15	various	various	ADJ
admet-881	108	16	dosage	dosage	NOUN
admet-881	108	17	forms	form	NOUN
admet-881	108	18	,	,	PUNCT
admet-881	108	19	such	such	ADJ
admet-881	108	20	as	as	ADP
admet-881	108	21	nanoformulations	nanoformulation	NOUN
admet-881	108	22	and	and	CCONJ
admet-881	108	23	various	various	ADJ
admet-881	108	24	pharmaceutical	pharmaceutical	ADJ
admet-881	108	25	excipients	excipient	NOUN
admet-881	108	26	,	,	PUNCT
admet-881	108	27	and	and	CCONJ
admet-881	108	28	intestinal	intestinal	ADJ
admet-881	108	29	permeability	permeability	NOUN
admet-881	108	30	,	,	PUNCT
admet-881	108	31	during	during	ADP
admet-881	108	32	both	both	CCONJ
admet-881	108	33	fed	feed	VERB
admet-881	108	34	and	and	CCONJ
admet-881	108	35	fasted	fast	VERB
admet-881	108	36	conditions	condition	NOUN
admet-881	108	37	[	[	X
admet-881	108	38	55	55	NUM
admet-881	108	39	]	]	PUNCT
admet-881	108	40	.	.	PUNCT
admet-881	109	1	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	PROPN
admet-881	109	2	h.	h.	PROPN
admet-881	109	3	lennernäs	lennernäs	PROPN
admet-881	109	4	et	et	PROPN
admet-881	109	5	al	al	PROPN
admet-881	109	6	.	.	PROPN
admet-881	109	7	admet	admet	PROPN
admet-881	109	8	&	&	CCONJ
admet-881	109	9	dmpk	dmpk	PROPN
admet-881	109	10	8(4	8(4	NOUN
admet-881	109	11	)	)	PUNCT
admet-881	109	12	(	(	PUNCT
admet-881	109	13	2020	2020	NUM
admet-881	109	14	)	)	PUNCT
admet-881	109	15	375	375	NUM
admet-881	109	16	-	-	SYM
admet-881	109	17	390	390	NUM
admet-881	109	18	380	380	NUM
admet-881	109	19	figure	figure	NOUN
admet-881	109	20	2	2	NUM
admet-881	109	21	.	.	PUNCT
admet-881	109	22	graphical	graphical	ADJ
admet-881	109	23	illustration	illustration	NOUN
admet-881	109	24	of	of	ADP
admet-881	109	25	a	a	DET
admet-881	109	26	single	single	ADJ
admet-881	109	27	-	-	PUNCT
admet-881	109	28	pass	pass	ADJ
admet-881	109	29	intestinal	intestinal	ADJ
admet-881	109	30	perfusion	perfusion	NOUN
admet-881	109	31	(	(	PUNCT
admet-881	109	32	spip	spip	PROPN
admet-881	109	33	)	)	PUNCT
admet-881	109	34	in	in	ADP
admet-881	109	35	rat	rat	NOUN
admet-881	109	36	with	with	ADP
admet-881	109	37	the	the	DET
admet-881	109	38	intestinal	intestinal	ADJ
admet-881	109	39	segment	segment	NOUN
admet-881	109	40	placed	place	VERB
admet-881	109	41	on	on	ADP
admet-881	109	42	the	the	DET
admet-881	109	43	outside	outside	NOUN
admet-881	109	44	of	of	ADP
admet-881	109	45	the	the	DET
admet-881	109	46	abdomen	abdoman	NOUN
admet-881	109	47	.	.	PUNCT
admet-881	110	1	the	the	DET
admet-881	110	2	different	different	ADJ
admet-881	110	3	numbers	number	NOUN
admet-881	110	4	show	show	VERB
admet-881	110	5	:	:	PUNCT
admet-881	110	6	1	1	X
admet-881	110	7	)	)	PUNCT
admet-881	110	8	perfusion	perfusion	NOUN
admet-881	110	9	solution	solution	NOUN
admet-881	110	10	/	/	SYM
admet-881	110	11	suspension	suspension	NOUN
admet-881	110	12	under	under	ADP
admet-881	110	13	constant	constant	ADJ
admet-881	110	14	stirring	stirring	NOUN
admet-881	110	15	on	on	ADP
admet-881	110	16	a	a	DET
admet-881	110	17	heating	heating	NOUN
admet-881	110	18	table	table	NOUN
admet-881	110	19	,	,	PUNCT
admet-881	110	20	and	and	CCONJ
admet-881	110	21	perfused	perfuse	VERB
admet-881	110	22	using	use	VERB
admet-881	110	23	a	a	DET
admet-881	110	24	peristaltic	peristaltic	ADJ
admet-881	110	25	pump	pump	NOUN
admet-881	110	26	;	;	PUNCT
admet-881	110	27	2	2	X
admet-881	110	28	)	)	PUNCT
admet-881	110	29	a	a	DET
admet-881	110	30	syringe	syringe	NOUN
admet-881	110	31	pump	pump	NOUN
admet-881	110	32	allows	allow	VERB
admet-881	110	33	coadministration	coadministration	NOUN
admet-881	110	34	of	of	ADP
admet-881	110	35	e.g.	e.g.	ADV
admet-881	110	36	,	,	PUNCT
admet-881	110	37	enzymes	enzyme	NOUN
admet-881	110	38	;	;	PUNCT
admet-881	110	39	3	3	X
admet-881	110	40	)	)	PUNCT
admet-881	110	41	perfusate	perfusate	NOUN
admet-881	110	42	is	be	AUX
admet-881	110	43	collected	collect	VERB
admet-881	110	44	after	after	ADP
admet-881	110	45	passing	pass	VERB
admet-881	110	46	through	through	ADP
admet-881	110	47	an	an	DET
admet-881	110	48	intestinal	intestinal	ADJ
admet-881	110	49	segment	segment	NOUN
admet-881	110	50	;	;	PUNCT
admet-881	110	51	4	4	X
admet-881	110	52	)	)	PUNCT
admet-881	110	53	blood	blood	NOUN
admet-881	110	54	sampling	sample	VERB
admet-881	110	55	from	from	ADP
admet-881	110	56	the	the	DET
admet-881	110	57	femoral	femoral	ADJ
admet-881	110	58	artery	artery	NOUN
admet-881	110	59	;	;	PUNCT
admet-881	110	60	5	5	X
admet-881	110	61	)	)	PUNCT
admet-881	110	62	body	body	NOUN
admet-881	110	63	temperature	temperature	NOUN
admet-881	110	64	is	be	AUX
admet-881	110	65	monitored	monitor	VERB
admet-881	110	66	using	use	VERB
admet-881	110	67	a	a	DET
admet-881	110	68	rectal	rectal	ADJ
admet-881	110	69	probe	probe	NOUN
admet-881	110	70	,	,	PUNCT
admet-881	110	71	connected	connect	VERB
admet-881	110	72	to	to	ADP
admet-881	110	73	a	a	DET
admet-881	110	74	heating	heating	NOUN
admet-881	110	75	pad	pad	NOUN
admet-881	110	76	;	;	PUNCT
admet-881	110	77	6	6	X
admet-881	110	78	)	)	PUNCT
admet-881	110	79	blood	blood	NOUN
admet-881	110	80	pressure	pressure	NOUN
admet-881	110	81	and	and	CCONJ
admet-881	110	82	heart	heart	NOUN
admet-881	110	83	rate	rate	NOUN
admet-881	110	84	are	be	AUX
admet-881	110	85	monitored	monitor	VERB
admet-881	110	86	in	in	ADP
admet-881	110	87	the	the	DET
admet-881	110	88	femoral	femoral	ADJ
admet-881	110	89	artery	artery	NOUN
admet-881	110	90	.	.	PUNCT
admet-881	111	1	in	in	ADP
admet-881	111	2	the	the	DET
admet-881	111	3	spip	spip	PROPN
admet-881	111	4	model	model	NOUN
admet-881	111	5	,	,	PUNCT
admet-881	111	6	absorption	absorption	NOUN
admet-881	111	7	parameters	parameter	NOUN
admet-881	111	8	can	can	AUX
admet-881	111	9	be	be	AUX
admet-881	111	10	calculated	calculate	VERB
admet-881	111	11	in	in	ADP
admet-881	111	12	several	several	ADJ
admet-881	111	13	ways	way	NOUN
admet-881	111	14	.	.	PUNCT
admet-881	112	1	one	one	NUM
admet-881	112	2	of	of	ADP
admet-881	112	3	the	the	DET
admet-881	112	4	most	most	ADV
admet-881	112	5	common	common	ADJ
admet-881	112	6	is	be	AUX
admet-881	112	7	to	to	PART
admet-881	112	8	calculate	calculate	VERB
admet-881	112	9	effective	effective	ADJ
admet-881	112	10	permeability	permeability	NOUN
admet-881	112	11	(	(	PUNCT
admet-881	112	12	peff	peff	PROPN
admet-881	112	13	)	)	PUNCT
admet-881	112	14	,	,	PUNCT
admet-881	112	15	which	which	PRON
admet-881	112	16	is	be	AUX
admet-881	112	17	based	base	VERB
admet-881	112	18	determining	determine	VERB
admet-881	112	19	the	the	DET
admet-881	112	20	disappearance	disappearance	NOUN
admet-881	112	21	of	of	ADP
admet-881	112	22	an	an	DET
admet-881	112	23	api	api	NOUN
admet-881	112	24	from	from	ADP
admet-881	112	25	the	the	DET
admet-881	112	26	intestinal	intestinal	ADJ
admet-881	112	27	lumen	luman	NOUN
admet-881	112	28	during	during	ADP
admet-881	112	29	single	single	ADJ
admet-881	112	30	-	-	PUNCT
admet-881	112	31	pass	pass	NOUN
admet-881	112	32	perfusion	perfusion	NOUN
admet-881	112	33	of	of	ADP
admet-881	112	34	a	a	DET
admet-881	112	35	well	well	ADV
admet-881	112	36	-	-	PUNCT
admet-881	112	37	defined	define	VERB
admet-881	112	38	intestinal	intestinal	ADJ
admet-881	112	39	segment	segment	NOUN
admet-881	112	40	(	(	PUNCT
admet-881	112	41	equation	equation	NOUN
admet-881	112	42	3	3	NUM
admet-881	112	43	):	):	PUNCT
admet-881	112	44			NOUN
admet-881	112	45	in	in	VERB
admet-881	112	46	out	out	ADP
admet-881	112	47	inln	inln	PROPN
admet-881	112	48	/	/	SYM
admet-881	112	49	eff	eff	PROPN
admet-881	112	50	q	q	PROPN
admet-881	112	51	c	c	NOUN
admet-881	112	52	c	c	PROPN
admet-881	112	53	p	p	NOUN
admet-881	112	54	a	a	DET
admet-881	112	55			NOUN
admet-881	112	56			NUM
admet-881	112	57	(	(	PUNCT
admet-881	112	58	3	3	NUM
admet-881	112	59	)	)	PUNCT
admet-881	112	60	where	where	SCONJ
admet-881	112	61	qin	qin	PROPN
admet-881	112	62	is	be	AUX
admet-881	112	63	the	the	DET
admet-881	112	64	perfusate	perfusate	ADJ
admet-881	112	65	flow	flow	NOUN
admet-881	112	66	rate	rate	NOUN
admet-881	112	67	,	,	PUNCT
admet-881	112	68	cout	cout	PROPN
admet-881	112	69	(	(	PUNCT
admet-881	112	70	corrected	correct	VERB
admet-881	112	71	for	for	ADP
admet-881	112	72	water	water	NOUN
admet-881	112	73	flux	flux	NOUN
admet-881	112	74	)	)	PUNCT
admet-881	112	75	and	and	CCONJ
admet-881	112	76	cin	cin	PROPN
admet-881	112	77	are	be	AUX
admet-881	112	78	the	the	DET
admet-881	112	79	concentrations	concentration	NOUN
admet-881	112	80	of	of	ADP
admet-881	112	81	api	api	NOUN
admet-881	112	82	leaving	leaving	NOUN
admet-881	112	83	and	and	CCONJ
admet-881	112	84	entering	enter	VERB
admet-881	112	85	the	the	DET
admet-881	112	86	intestinal	intestinal	ADJ
admet-881	112	87	segment	segment	NOUN
admet-881	112	88	,	,	PUNCT
admet-881	112	89	and	and	CCONJ
admet-881	112	90	a	a	PRON
admet-881	112	91	is	be	AUX
admet-881	112	92	the	the	DET
admet-881	112	93	surface	surface	NOUN
admet-881	112	94	area	area	NOUN
admet-881	112	95	of	of	ADP
admet-881	112	96	the	the	DET
admet-881	112	97	perfused	perfuse	VERB
admet-881	112	98	intestinal	intestinal	ADJ
admet-881	112	99	segment	segment	NOUN
admet-881	112	100	,	,	PUNCT
admet-881	112	101	which	which	PRON
admet-881	112	102	is	be	AUX
admet-881	112	103	assumed	assume	VERB
admet-881	112	104	to	to	PART
admet-881	112	105	be	be	AUX
admet-881	112	106	a	a	DET
admet-881	112	107	smooth	smooth	ADJ
admet-881	112	108	cylinder	cylinder	NOUN
admet-881	113	1	[	[	X
admet-881	113	2	56	56	NUM
admet-881	113	3	]	]	PUNCT
admet-881	113	4	.	.	PUNCT
admet-881	114	1	the	the	DET
admet-881	114	2	cout	cout	NOUN
admet-881	114	3	is	be	AUX
admet-881	114	4	corrected	correct	VERB
admet-881	114	5	for	for	ADP
admet-881	114	6	water	water	NOUN
admet-881	114	7	flux	flux	NOUN
admet-881	114	8	using	use	VERB
admet-881	114	9	an	an	DET
admet-881	114	10	unabsorbable	unabsorbable	ADJ
admet-881	114	11	marker	marker	NOUN
admet-881	114	12	and	and	CCONJ
admet-881	114	13	by	by	ADP
admet-881	114	14	weighing	weigh	VERB
admet-881	114	15	the	the	DET
admet-881	114	16	luminal	luminal	ADJ
admet-881	114	17	perfusates	perfusate	NOUN
admet-881	114	18	leaving	leave	VERB
admet-881	114	19	the	the	DET
admet-881	114	20	segment	segment	NOUN
admet-881	114	21	[	[	X
admet-881	114	22	57	57	NUM
admet-881	114	23	]	]	PUNCT
admet-881	114	24	.	.	PUNCT
admet-881	115	1	the	the	DET
admet-881	115	2	disappearance	disappearance	NOUN
admet-881	115	3	flux	flux	NOUN
admet-881	115	4	(	(	PUNCT
admet-881	115	5	jdisapp	jdisapp	NOUN
admet-881	115	6	)	)	PUNCT
admet-881	115	7	of	of	ADP
admet-881	115	8	an	an	DET
admet-881	115	9	api	api	NOUN
admet-881	115	10	can	can	AUX
admet-881	115	11	also	also	ADV
admet-881	115	12	be	be	AUX
admet-881	115	13	calculated	calculate	VERB
admet-881	115	14	from	from	ADP
admet-881	115	15	perfusate	perfusate	ADJ
admet-881	115	16	data	datum	NOUN
admet-881	115	17	leaving	leave	VERB
admet-881	115	18	the	the	DET
admet-881	115	19	intestinal	intestinal	ADJ
admet-881	115	20	segment	segment	NOUN
admet-881	115	21	by	by	ADP
admet-881	115	22	correcting	correct	VERB
admet-881	115	23	for	for	ADP
admet-881	115	24	water	water	NOUN
admet-881	115	25	flux	flux	NOUN
admet-881	115	26	as	as	SCONJ
admet-881	115	27	previously	previously	ADV
admet-881	115	28	described	describe	VERB
admet-881	115	29	(	(	PUNCT
admet-881	115	30	equation	equation	NOUN
admet-881	115	31	4	4	NUM
admet-881	115	32	):	):	PUNCT
admet-881	115	33			NOUN
admet-881	115	34	in	in	VERB
admet-881	115	35	in	in	ADP
admet-881	115	36	out	out	ADP
admet-881	115	37	disapp	disapp	PROPN
admet-881	115	38	q	q	PROPN
admet-881	116	1	c	c	NOUN
admet-881	116	2	c	c	PROPN
admet-881	116	3	j	j	PROPN
admet-881	116	4	a	a	DET
admet-881	116	5			PROPN
admet-881	116	6			NOUN
admet-881	116	7	(	(	PUNCT
admet-881	116	8	4	4	NUM
admet-881	116	9	)	)	PUNCT
admet-881	116	10	alternatively	alternatively	ADV
admet-881	116	11	,	,	PUNCT
admet-881	116	12	absorption	absorption	NOUN
admet-881	116	13	flux	flux	NOUN
admet-881	116	14	(	(	PUNCT
admet-881	116	15	japp	japp	ADJ
admet-881	116	16	)	)	PUNCT
admet-881	116	17	can	can	AUX
admet-881	116	18	be	be	AUX
admet-881	116	19	calculated	calculate	VERB
admet-881	116	20	in	in	ADP
admet-881	116	21	the	the	DET
admet-881	116	22	spip	spip	NOUN
admet-881	116	23	model	model	NOUN
admet-881	116	24	by	by	ADP
admet-881	116	25	monitoring	monitor	VERB
admet-881	116	26	plasma	plasma	NOUN
admet-881	116	27	drug	drug	NOUN
admet-881	116	28	appearance	appearance	NOUN
admet-881	116	29	using	use	VERB
admet-881	116	30	the	the	DET
admet-881	116	31	deconvolution	deconvolution	NOUN
admet-881	116	32	method	method	NOUN
admet-881	116	33	(	(	PUNCT
admet-881	116	34	equation	equation	NOUN
admet-881	116	35	5	5	NUM
admet-881	116	36	)	)	PUNCT
admet-881	116	37	.	.	PUNCT
admet-881	117	1	however	however	ADV
admet-881	117	2	,	,	PUNCT
admet-881	117	3	this	this	PRON
admet-881	117	4	requires	require	VERB
admet-881	117	5	a	a	DET
admet-881	117	6	separate	separate	ADJ
admet-881	117	7	intravenous	intravenous	ADJ
admet-881	117	8	injection	injection	NOUN
admet-881	117	9	of	of	ADP
admet-881	117	10	the	the	DET
admet-881	117	11	study	study	NOUN
admet-881	117	12	drug	drug	NOUN
admet-881	117	13	for	for	ADP
admet-881	117	14	calculating	calculate	VERB
admet-881	117	15	the	the	DET
admet-881	117	16	disposition	disposition	NOUN
admet-881	117	17	pk	pk	NOUN
admet-881	117	18	parameters	parameter	NOUN
admet-881	117	19	in	in	ADP
admet-881	117	20	the	the	DET
admet-881	117	21	deconvolution	deconvolution	NOUN
admet-881	117	22	.	.	PUNCT
admet-881	118	1	app	app	PROPN
admet-881	118	2	input	input	PROPN
admet-881	118	3	 	 	SPACE
admet-881	118	4	rate	rate	NOUN
admet-881	118	5	j	j	PROPN
admet-881	118	6	a	a	DET
admet-881	118	7			PROPN
admet-881	118	8	(	(	PUNCT
admet-881	118	9	5	5	NUM
admet-881	118	10	)	)	PUNCT
admet-881	119	1	the	the	DET
admet-881	119	2	pig	pig	NOUN
admet-881	119	3	data	datum	NOUN
admet-881	119	4	in	in	ADP
admet-881	119	5	this	this	DET
admet-881	119	6	review	review	NOUN
admet-881	119	7	are	be	AUX
admet-881	119	8	based	base	VERB
admet-881	119	9	on	on	ADP
admet-881	119	10	the	the	DET
admet-881	119	11	same	same	ADJ
admet-881	119	12	perfusion	perfusion	NOUN
admet-881	119	13	setup	setup	NOUN
admet-881	119	14	as	as	ADP
admet-881	119	15	the	the	DET
admet-881	119	16	loc	loc	PROPN
admet-881	119	17	-	-	PUNCT
admet-881	119	18	i	i	NOUN
admet-881	119	19	-	-	PUNCT
admet-881	119	20	gut	gut	NOUN
admet-881	119	21	model	model	NOUN
admet-881	119	22	,	,	PUNCT
admet-881	119	23	for	for	ADP
admet-881	119	24	which	which	PRON
admet-881	119	25	it	it	PRON
admet-881	119	26	has	have	AUX
admet-881	119	27	been	be	AUX
admet-881	119	28	clearly	clearly	ADV
admet-881	119	29	shown	show	VERB
admet-881	119	30	that	that	SCONJ
admet-881	119	31	a	a	DET
admet-881	119	32	well	well	ADV
admet-881	119	33	-	-	PUNCT
admet-881	119	34	stirred	stir	VERB
admet-881	119	35	model	model	NOUN
admet-881	119	36	describes	describe	VERB
admet-881	119	37	the	the	DET
admet-881	119	38	hydrodynamics	hydrodynamic	NOUN
admet-881	119	39	during	during	ADP
admet-881	119	40	single	single	ADJ
admet-881	119	41	-	-	PUNCT
admet-881	119	42	pass	pass	NOUN
admet-881	119	43	experiment	experiment	NOUN
admet-881	119	44	[	[	X
admet-881	119	45	56,58	56,58	NUM
admet-881	119	46	]	]	PUNCT
admet-881	119	47	.	.	PUNCT
admet-881	120	1	the	the	DET
admet-881	120	2	following	follow	VERB
admet-881	120	3	calculations	calculation	NOUN
admet-881	120	4	from	from	ADP
admet-881	120	5	the	the	DET
admet-881	120	6	perfusion	perfusion	NOUN
admet-881	120	7	experiments	experiment	NOUN
admet-881	120	8	in	in	ADP
admet-881	120	9	the	the	DET
admet-881	120	10	pig	pig	NOUN
admet-881	120	11	spip	spip	PROPN
admet-881	120	12	model	model	NOUN
admet-881	120	13	were	be	AUX
admet-881	120	14	made	make	VERB
admet-881	120	15	from	from	ADP
admet-881	120	16	steady	steady	ADJ
admet-881	120	17	-	-	PUNCT
admet-881	120	18	state	state	NOUN
admet-881	120	19	concentrations	concentration	NOUN
admet-881	120	20	of	of	ADP
admet-881	120	21	the	the	DET
admet-881	120	22	outlet	outlet	NOUN
admet-881	120	23	jejunal	jejunal	PROPN
admet-881	120	24	perfusate	perfusate	NOUN
admet-881	120	25	[	[	X
admet-881	120	26	55	55	NUM
admet-881	120	27	]	]	PUNCT
admet-881	120	28	.	.	PUNCT
admet-881	121	1	the	the	DET
admet-881	121	2	fraction	fraction	NOUN
admet-881	121	3	of	of	ADP
admet-881	121	4	the	the	DET
admet-881	121	5	drug	drug	NOUN
admet-881	121	6	absorbed	absorb	VERB
admet-881	121	7	in	in	ADP
admet-881	121	8	the	the	DET
admet-881	121	9	segment	segment	NOUN
admet-881	121	10	during	during	ADP
admet-881	121	11	the	the	DET
admet-881	121	12	perfusion	perfusion	NOUN
admet-881	121	13	(	(	PUNCT
admet-881	121	14	fabs	fab	NOUN
admet-881	121	15	)	)	PUNCT
admet-881	121	16	was	be	AUX
admet-881	121	17	calculated	calculate	VERB
admet-881	121	18	from	from	ADP
admet-881	121	19	equation	equation	NOUN
admet-881	121	20	6	6	NUM
admet-881	121	21	:	:	PUNCT
admet-881	121	22	admet	admet	PROPN
admet-881	121	23	&	&	CCONJ
admet-881	121	24	dmpk	dmpk	PROPN
admet-881	121	25	8(4	8(4	NOUN
admet-881	121	26	)	)	PUNCT
admet-881	121	27	(	(	PUNCT
admet-881	121	28	2020	2020	NUM
admet-881	121	29	)	)	PUNCT
admet-881	121	30	375	375	NUM
admet-881	121	31	-	-	SYM
admet-881	121	32	390	390	NUM
admet-881	121	33	intestinal	intestinal	ADJ
admet-881	121	34	absorption	absorption	NOUN
admet-881	121	35	of	of	ADP
admet-881	121	36	bcs	bcs	NOUN
admet-881	121	37	class	class	NOUN
admet-881	121	38	ii	ii	PROPN
admet-881	121	39	drugs	drug	NOUN
admet-881	121	40	nanoparticles	nanoparticle	NOUN
admet-881	121	41	doi	doi	NOUN
admet-881	121	42	:	:	PUNCT
admet-881	121	43	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	121	44	381	381	NUM
admet-881	121	45	in	in	ADP
admet-881	121	46	abs	ab	NOUN
admet-881	121	47	out	out	ADP
admet-881	121	48	  	  	SPACE
admet-881	121	49	1	1	NUM
admet-881	121	50	  	  	SPACE
admet-881	121	51	out	out	ADV
admet-881	121	52	in	in	ADP
admet-881	121	53	c	c	NOUN
admet-881	121	54	peg	peg	NOUN
admet-881	121	55	f	f	PROPN
admet-881	121	56	c	c	PROPN
admet-881	121	57	peg	peg	PROPN
admet-881	121	58			NOUN
admet-881	121	59			PROPN
admet-881	121	60			PROPN
admet-881	121	61			PROPN
admet-881	121	62			PROPN
admet-881	122	1			ADP
admet-881	122	2			NOUN
admet-881	122	3	(	(	PUNCT
admet-881	122	4	6	6	NUM
admet-881	122	5	)	)	PUNCT
admet-881	122	6	where	where	SCONJ
admet-881	122	7	cin	cin	PROPN
admet-881	122	8	and	and	CCONJ
admet-881	122	9	cout	cout	NOUN
admet-881	122	10	are	be	AUX
admet-881	122	11	the	the	DET
admet-881	122	12	concentrations	concentration	NOUN
admet-881	122	13	of	of	ADP
admet-881	122	14	the	the	DET
admet-881	122	15	study	study	NOUN
admet-881	122	16	drug	drug	NOUN
admet-881	122	17	,	,	PUNCT
admet-881	122	18	and	and	CCONJ
admet-881	122	19	pegin	pegin	NOUN
admet-881	122	20	and	and	CCONJ
admet-881	122	21	pegout	pegout	NOUN
admet-881	122	22	are	be	AUX
admet-881	122	23	the	the	DET
admet-881	122	24	non	non	ADJ
admet-881	122	25	-	-	ADJ
admet-881	122	26	absorbable	absorbable	ADJ
admet-881	122	27	volume	volume	NOUN
admet-881	122	28	correction	correction	NOUN
admet-881	122	29	marker	marker	NOUN
admet-881	122	30	(	(	PUNCT
admet-881	122	31	[	[	X
admet-881	122	32	14c]-peg	14c]-peg	NUM
admet-881	122	33	4000	4000	NUM
admet-881	122	34	)	)	PUNCT
admet-881	122	35	,	,	PUNCT
admet-881	122	36	entering	enter	VERB
admet-881	122	37	and	and	CCONJ
admet-881	122	38	leaving	leave	VERB
admet-881	122	39	the	the	DET
admet-881	122	40	jejunal	jejunal	ADJ
admet-881	122	41	segment	segment	NOUN
admet-881	122	42	,	,	PUNCT
admet-881	122	43	respectively	respectively	ADV
admet-881	122	44	.	.	PUNCT
admet-881	123	1	the	the	DET
admet-881	123	2	jejunal	jejunal	ADJ
admet-881	123	3	peff	peff	PROPN
admet-881	123	4	of	of	ADP
admet-881	123	5	each	each	DET
admet-881	123	6	drug	drug	NOUN
admet-881	123	7	is	be	AUX
admet-881	123	8	calculated	calculate	VERB
admet-881	123	9	according	accord	VERB
admet-881	123	10	to	to	ADP
admet-881	123	11	a	a	DET
admet-881	123	12	well	well	ADV
admet-881	123	13	-	-	PUNCT
admet-881	123	14	mixed	mix	VERB
admet-881	123	15	tank	tank	NOUN
admet-881	123	16	model	model	NOUN
admet-881	123	17	,	,	PUNCT
admet-881	123	18	as	as	SCONJ
admet-881	123	19	shown	show	VERB
admet-881	123	20	in	in	ADP
admet-881	123	21	equation	equation	NOUN
admet-881	123	22	7	7	NUM
admet-881	124	1	[	[	X
admet-881	124	2	59	59	NUM
admet-881	124	3	]	]	PUNCT
admet-881	124	4	:	:	PUNCT
admet-881	124	5	in	in	ADP
admet-881	124	6	outin	outin	NOUN
admet-881	124	7	eff	eff	PROPN
admet-881	124	8	in	in	ADP
admet-881	124	9	  	  	SPACE
admet-881	124	10	a	a	DET
admet-881	124	11	c	c	NOUN
admet-881	124	12	cq	cq	NOUN
admet-881	124	13	p	p	PROPN
admet-881	124	14	c	c	PROPN
admet-881	124	15			NOUN
admet-881	124	16			NOUN
admet-881	125	1			PROPN
admet-881	125	2			NUM
admet-881	125	3			CCONJ
admet-881	125	4			ADJ
admet-881	125	5			NOUN
admet-881	125	6	(	(	PUNCT
admet-881	125	7	7	7	NUM
admet-881	125	8	)	)	PUNCT
admet-881	125	9	where	where	SCONJ
admet-881	125	10	a	a	PRON
admet-881	125	11	is	be	AUX
admet-881	125	12	the	the	DET
admet-881	125	13	cylindrical	cylindrical	ADJ
admet-881	125	14	area	area	NOUN
admet-881	125	15	of	of	ADP
admet-881	125	16	the	the	DET
admet-881	125	17	perfused	perfuse	VERB
admet-881	125	18	jejunal	jejunal	ADJ
admet-881	125	19	segment	segment	NOUN
admet-881	125	20	(	(	PUNCT
admet-881	125	21	a	a	NOUN
admet-881	125	22	)	)	PUNCT
admet-881	125	23	.	.	PUNCT
admet-881	126	1	in	in	ADP
admet-881	126	2	vivo	vivo	ADJ
admet-881	126	3	absorption	absorption	NOUN
admet-881	126	4	of	of	ADP
admet-881	126	5	four	four	NUM
admet-881	126	6	model	model	NOUN
admet-881	126	7	drugs	drug	NOUN
admet-881	126	8	,	,	PUNCT
admet-881	126	9	under	under	ADP
admet-881	126	10	different	different	ADJ
admet-881	126	11	luminal	luminal	ADJ
admet-881	126	12	conditions	condition	NOUN
admet-881	126	13	this	this	DET
admet-881	126	14	review	review	NOUN
admet-881	126	15	focuses	focus	VERB
admet-881	126	16	on	on	ADP
admet-881	126	17	the	the	DET
admet-881	126	18	in	in	ADP
admet-881	126	19	vivo	vivo	NOUN
admet-881	126	20	,	,	PUNCT
admet-881	126	21	small	small	ADJ
admet-881	126	22	intestine	intestine	NOUN
admet-881	126	23	absorption	absorption	NOUN
admet-881	126	24	of	of	ADP
admet-881	126	25	four	four	NUM
admet-881	126	26	bcs	bcs	NOUN
admet-881	126	27	class	class	NOUN
admet-881	126	28	ii	ii	NOUN
admet-881	126	29	drugs	drug	NOUN
admet-881	126	30	:	:	PUNCT
admet-881	126	31	aprepitant	aprepitant	ADJ
admet-881	126	32	,	,	PUNCT
admet-881	126	33	cyclosporine	cyclosporine	NOUN
admet-881	126	34	,	,	PUNCT
admet-881	126	35	danazol	danazol	ADJ
admet-881	126	36	,	,	PUNCT
admet-881	126	37	and	and	CCONJ
admet-881	126	38	fenofibrate	fenofibrate	NOUN
admet-881	126	39	.	.	PUNCT
admet-881	127	1	a	a	DET
admet-881	127	2	range	range	NOUN
admet-881	127	3	of	of	ADP
admet-881	127	4	physicochemical	physicochemical	ADJ
admet-881	127	5	properties	property	NOUN
admet-881	127	6	of	of	ADP
admet-881	127	7	these	these	DET
admet-881	127	8	drugs	drug	NOUN
admet-881	127	9	are	be	AUX
admet-881	127	10	presented	present	VERB
admet-881	127	11	in	in	ADP
admet-881	127	12	table	table	NOUN
admet-881	127	13	2	2	NUM
admet-881	127	14	.	.	PUNCT
admet-881	128	1	they	they	PRON
admet-881	128	2	have	have	AUX
admet-881	128	3	been	be	AUX
admet-881	128	4	investigated	investigate	VERB
admet-881	128	5	in	in	ADP
admet-881	128	6	the	the	DET
admet-881	128	7	small	small	ADJ
admet-881	128	8	intestine	intestine	NOUN
admet-881	128	9	as	as	ADP
admet-881	128	10	nano	nano	NOUN
admet-881	128	11	-	-	PUNCT
admet-881	128	12	formulations	formulation	NOUN
admet-881	128	13	under	under	ADP
admet-881	128	14	different	different	ADJ
admet-881	128	15	luminal	luminal	ADJ
admet-881	128	16	conditions	condition	NOUN
admet-881	128	17	.	.	PUNCT
admet-881	129	1	table	table	NOUN
admet-881	129	2	2	2	NUM
admet-881	129	3	.	.	PUNCT
admet-881	129	4	physicochemical	physicochemical	ADJ
admet-881	129	5	descriptors	descriptor	NOUN
admet-881	129	6	of	of	ADP
admet-881	129	7	danazol	danazol	ADJ
admet-881	129	8	,	,	PUNCT
admet-881	129	9	cyclosporine	cyclosporine	NOUN
admet-881	129	10	,	,	PUNCT
admet-881	129	11	aprepitant	aprepitant	ADJ
admet-881	129	12	,	,	PUNCT
admet-881	129	13	and	and	CCONJ
admet-881	129	14	fenofibrate	fenofibrate	NOUN
admet-881	129	15	.	.	PUNCT
admet-881	129	16	danazol	danazol	ADJ
admet-881	130	1	[	[	X
admet-881	130	2	55,60	55,60	NUM
admet-881	130	3	]	]	PUNCT
admet-881	130	4	cyclosporine	cyclosporine	NOUN
admet-881	130	5	[	[	X
admet-881	130	6	55	55	NUM
admet-881	130	7	]	]	X
admet-881	130	8	aprepitant	aprepitant	NOUN
admet-881	130	9	[	[	X
admet-881	130	10	60	60	NUM
admet-881	130	11	]	]	PUNCT
admet-881	130	12	fenofibrate	fenofibrate	NOUN
admet-881	131	1	[	[	X
admet-881	131	2	60	60	NUM
admet-881	131	3	]	]	X
admet-881	131	4	molecular	molecular	ADJ
admet-881	131	5	mass	mass	NOUN
admet-881	131	6	(	(	PUNCT
admet-881	131	7	g	g	NOUN
admet-881	131	8	/	/	SYM
admet-881	131	9	mol	mol	NOUN
admet-881	131	10	)	)	PUNCT
admet-881	131	11	337	337	NUM
admet-881	131	12	1202	1202	NUM
admet-881	131	13	535	535	NUM
admet-881	131	14	361	361	NUM
admet-881	131	15	water	water	NOUN
admet-881	131	16	solubility	solubility	NOUN
admet-881	131	17	at	at	ADP
admet-881	131	18	37	37	NUM
admet-881	131	19	°	°	NOUN
admet-881	131	20	c	c	NOUN
admet-881	131	21	(	(	PUNCT
admet-881	131	22	µg	µg	NOUN
admet-881	131	23	/	/	SYM
admet-881	131	24	ml	ml	NOUN
admet-881	131	25	)	)	PUNCT
admet-881	131	26	0.5	0.5	NUM
admet-881	131	27	7	7	NUM
admet-881	131	28	0.37	0.37	NUM
admet-881	131	29	0.25	0.25	NUM
admet-881	131	30	log	log	NOUN
admet-881	131	31	p	p	NOUN
admet-881	131	32	3.7	3.7	NUM
admet-881	131	33	3	3	NUM
admet-881	131	34	4.7	4.7	NUM
admet-881	131	35	6.9	6.9	NUM
admet-881	131	36	papp	papp	NOUN
admet-881	131	37	(	(	PUNCT
admet-881	131	38	·	·	SYM
admet-881	131	39	10	10	NUM
admet-881	131	40	-6	-6	NOUN
admet-881	131	41	cm	cm	NOUN
admet-881	131	42	/	/	SYM
admet-881	131	43	s	s	PART
admet-881	131	44	)	)	PUNCT
admet-881	131	45	14.15	14.15	NUM
admet-881	131	46	2.6	2.6	NUM
admet-881	131	47	170	170	NUM
admet-881	131	48	220	220	NUM
admet-881	131	49	aprepitant	aprepitant	ADJ
admet-881	131	50	is	be	AUX
admet-881	131	51	an	an	DET
admet-881	131	52	orally	orally	ADV
admet-881	131	53	administered	administer	VERB
admet-881	131	54	neurokinin	neurokinin	ADJ
admet-881	131	55	nk-1	nk-1	X
admet-881	131	56	receptor	receptor	NOUN
admet-881	131	57	antagonist	antagonist	NOUN
admet-881	131	58	,	,	PUNCT
admet-881	131	59	used	use	VERB
admet-881	131	60	clinically	clinically	ADV
admet-881	131	61	to	to	PART
admet-881	131	62	prevent	prevent	VERB
admet-881	131	63	acute	acute	NOUN
admet-881	131	64	and	and	CCONJ
admet-881	131	65	delayed	delayed	ADJ
admet-881	131	66	chemotherapy	chemotherapy	NOUN
admet-881	131	67	-	-	ADJ
admet-881	131	68	induced	induce	VERB
admet-881	131	69	nausea	nausea	NOUN
admet-881	131	70	and	and	CCONJ
admet-881	131	71	vomiting	vomit	VERB
admet-881	131	72	[	[	X
admet-881	131	73	61	61	NUM
admet-881	131	74	]	]	PUNCT
admet-881	131	75	.	.	PUNCT
admet-881	132	1	the	the	DET
admet-881	132	2	molecular	molecular	ADJ
admet-881	132	3	mass	mass	NOUN
admet-881	132	4	is	be	AUX
admet-881	132	5	534	534	NUM
admet-881	132	6	da	da	NOUN
admet-881	132	7	.	.	PUNCT
admet-881	133	1	it	it	PRON
admet-881	133	2	has	have	VERB
admet-881	133	3	a	a	DET
admet-881	133	4	basic	basic	ADJ
admet-881	133	5	pka	pka	NOUN
admet-881	133	6	of	of	ADP
admet-881	133	7	2.4	2.4	NUM
admet-881	133	8	,	,	PUNCT
admet-881	133	9	an	an	DET
admet-881	133	10	acidic	acidic	ADJ
admet-881	133	11	pka	pka	NOUN
admet-881	133	12	of	of	ADP
admet-881	133	13	9.2	9.2	NUM
admet-881	133	14	,	,	PUNCT
admet-881	133	15	and	and	CCONJ
admet-881	133	16	is	be	AUX
admet-881	133	17	primarily	primarily	ADV
admet-881	133	18	uncharged	uncharged	ADJ
admet-881	133	19	at	at	ADP
admet-881	133	20	a	a	DET
admet-881	133	21	jejunal	jejunal	ADJ
admet-881	133	22	ph	ph	NOUN
admet-881	133	23	of	of	ADP
admet-881	133	24	6.5	6.5	NUM
admet-881	133	25	.	.	PUNCT
admet-881	134	1	the	the	DET
admet-881	134	2	aqueous	aqueous	ADJ
admet-881	134	3	solubility	solubility	NOUN
admet-881	134	4	is	be	AUX
admet-881	134	5	poor	poor	ADJ
admet-881	134	6	(	(	PUNCT
admet-881	134	7	0.37	0.37	NUM
admet-881	134	8	μg	μg	NOUN
admet-881	134	9	/	/	SYM
admet-881	134	10	ml	ml	PROPN
admet-881	134	11	)	)	PUNCT
admet-881	134	12	and	and	CCONJ
admet-881	134	13	it	it	PRON
admet-881	134	14	has	have	VERB
admet-881	134	15	a	a	DET
admet-881	134	16	high	high	ADJ
admet-881	134	17	apparent	apparent	ADJ
admet-881	134	18	permeability	permeability	NOUN
admet-881	134	19	(	(	PUNCT
admet-881	134	20	papp	papp	NOUN
admet-881	134	21	)	)	PUNCT
admet-881	134	22	in	in	ADP
admet-881	134	23	caco-2	caco-2	NUM
admet-881	134	24	cells	cell	NOUN
admet-881	134	25	(	(	PUNCT
admet-881	134	26	1.7·10−4	1.7·10−4	NUM
admet-881	134	27	cm	cm	NOUN
admet-881	134	28	/	/	SYM
admet-881	134	29	s	s	NOUN
admet-881	134	30	)	)	PUNCT
admet-881	134	31	,	,	PUNCT
admet-881	134	32	which	which	PRON
admet-881	134	33	predicts	predict	VERB
admet-881	134	34	a	a	DET
admet-881	134	35	high	high	ADJ
admet-881	134	36	peff	peff	NOUN
admet-881	134	37	in	in	ADP
admet-881	134	38	both	both	CCONJ
admet-881	134	39	small	small	ADJ
admet-881	134	40	and	and	CCONJ
admet-881	134	41	large	large	ADJ
admet-881	134	42	intestine	intestine	NOUN
admet-881	135	1	[	[	X
admet-881	135	2	62	62	NUM
admet-881	135	3	]	]	PUNCT
admet-881	135	4	.	.	PUNCT
admet-881	136	1	in	in	ADP
admet-881	136	2	fact	fact	NOUN
admet-881	136	3	,	,	PUNCT
admet-881	136	4	the	the	DET
admet-881	136	5	rat	rat	NOUN
admet-881	136	6	small	small	ADJ
admet-881	136	7	intestinal	intestinal	ADJ
admet-881	136	8	peff	peff	NOUN
admet-881	136	9	is	be	AUX
admet-881	136	10	reported	report	VERB
admet-881	136	11	to	to	PART
admet-881	136	12	be	be	AUX
admet-881	136	13	1.7·10−4	1.7·10−4	NUM
admet-881	136	14	cm	cm	NOUN
admet-881	136	15	/	/	SYM
admet-881	136	16	s	s	PART
admet-881	136	17	[	[	X
admet-881	136	18	63	63	NUM
admet-881	136	19	]	]	PUNCT
admet-881	136	20	.	.	PUNCT
admet-881	137	1	aprepitant	aprepitant	PROPN
admet-881	137	2	is	be	AUX
admet-881	137	3	mainly	mainly	ADV
admet-881	137	4	metabolized	metabolize	VERB
admet-881	137	5	by	by	ADP
admet-881	137	6	gut	gut	NOUN
admet-881	137	7	and	and	CCONJ
admet-881	137	8	hepatic	hepatic	ADJ
admet-881	137	9	cyp3a4	cyp3a4	NOUN
admet-881	137	10	,	,	PUNCT
admet-881	137	11	which	which	PRON
admet-881	137	12	means	mean	VERB
admet-881	137	13	that	that	SCONJ
admet-881	137	14	plasma	plasma	NOUN
admet-881	137	15	pharmacokinetics	pharmacokinetic	NOUN
admet-881	137	16	(	(	PUNCT
admet-881	137	17	i.e.	i.e.	X
admet-881	137	18	f	f	X
admet-881	137	19	)	)	PUNCT
admet-881	137	20	can	can	AUX
admet-881	137	21	be	be	AUX
admet-881	137	22	affected	affect	VERB
admet-881	137	23	by	by	ADP
admet-881	137	24	differences	difference	NOUN
admet-881	137	25	in	in	ADP
admet-881	137	26	small	small	ADJ
admet-881	137	27	intestinal	intestinal	ADJ
admet-881	137	28	absorption	absorption	NOUN
admet-881	137	29	rate	rate	NOUN
admet-881	137	30	[	[	X
admet-881	137	31	64	64	NUM
admet-881	137	32	]	]	PUNCT
admet-881	137	33	.	.	PUNCT
admet-881	138	1	the	the	DET
admet-881	138	2	oral	oral	ADJ
admet-881	138	3	product	product	NOUN
admet-881	138	4	with	with	ADP
admet-881	138	5	aprepitant	aprepitant	ADJ
admet-881	138	6	(	(	PUNCT
admet-881	138	7	emend	emend	NOUN
admet-881	138	8	;	;	PUNCT
admet-881	138	9	merck	merck	PROPN
admet-881	138	10	&	&	CCONJ
admet-881	138	11	co.	co.	PROPN
admet-881	138	12	,	,	PUNCT
admet-881	138	13	inc	inc	PROPN
admet-881	138	14	.	.	PROPN
admet-881	138	15	,	,	PUNCT
admet-881	138	16	nj	nj	PROPN
admet-881	138	17	)	)	PUNCT
admet-881	138	18	is	be	AUX
admet-881	138	19	based	base	VERB
admet-881	138	20	on	on	ADP
admet-881	138	21	nanoparticles	nanoparticle	NOUN
admet-881	138	22	of	of	ADP
admet-881	138	23	the	the	DET
admet-881	138	24	api	api	NOUN
admet-881	138	25	and	and	CCONJ
admet-881	138	26	has	have	VERB
admet-881	138	27	an	an	DET
admet-881	138	28	average	average	ADJ
admet-881	138	29	particle	particle	NOUN
admet-881	138	30	diameter	diameter	NOUN
admet-881	138	31	below	below	ADP
admet-881	138	32	200	200	NUM
admet-881	138	33	nm	nm	NOUN
admet-881	138	34	.	.	PUNCT
admet-881	139	1	these	these	DET
admet-881	139	2	particles	particle	NOUN
admet-881	139	3	are	be	AUX
admet-881	139	4	coated	coat	VERB
admet-881	139	5	onto	onto	ADP
admet-881	139	6	larger	large	ADJ
admet-881	139	7	cellulose	cellulose	NOUN
admet-881	139	8	beads	bead	NOUN
admet-881	139	9	and	and	CCONJ
admet-881	139	10	encapsulated	encapsulate	VERB
admet-881	139	11	[	[	PUNCT
admet-881	139	12	65	65	NUM
admet-881	139	13	]	]	PUNCT
admet-881	139	14	.	.	PUNCT
admet-881	140	1	cyclosporine	cyclosporine	PROPN
admet-881	140	2	is	be	AUX
admet-881	140	3	an	an	DET
admet-881	140	4	immunosuppressant	immunosuppressant	NOUN
admet-881	140	5	used	use	VERB
admet-881	140	6	to	to	PART
admet-881	140	7	prevent	prevent	VERB
admet-881	140	8	organ	organ	NOUN
admet-881	140	9	transplant	transplant	NOUN
admet-881	140	10	rejection	rejection	NOUN
admet-881	140	11	and	and	CCONJ
admet-881	140	12	danazol	danazol	ADJ
admet-881	140	13	is	be	AUX
admet-881	140	14	a	a	DET
admet-881	140	15	steroid	steroid	NOUN
admet-881	140	16	used	use	VERB
admet-881	140	17	to	to	PART
admet-881	140	18	treat	treat	VERB
admet-881	140	19	endometriosis	endometriosis	NOUN
admet-881	140	20	.	.	PUNCT
admet-881	141	1	as	as	ADP
admet-881	141	2	evident	evident	ADJ
admet-881	141	3	by	by	ADP
admet-881	141	4	their	their	PRON
admet-881	141	5	bcs	bcs	NOUN
admet-881	141	6	class	class	NOUN
admet-881	141	7	ii	ii	PROPN
admet-881	141	8	classification	classification	NOUN
admet-881	141	9	,	,	PUNCT
admet-881	141	10	both	both	CCONJ
admet-881	141	11	cyclosporine	cyclosporine	ADJ
admet-881	141	12	and	and	CCONJ
admet-881	141	13	danazol	danazol	ADJ
admet-881	141	14	have	have	VERB
admet-881	141	15	high	high	ADJ
admet-881	141	16	intestinal	intestinal	ADJ
admet-881	141	17	permeability	permeability	NOUN
admet-881	141	18	values	value	NOUN
admet-881	141	19	and	and	CCONJ
admet-881	141	20	low	low	ADJ
admet-881	141	21	aqueous	aqueous	ADJ
admet-881	141	22	solubility	solubility	NOUN
admet-881	141	23	.	.	PUNCT
admet-881	142	1	both	both	PRON
admet-881	142	2	cyclosporine	cyclosporine	VERB
admet-881	142	3	and	and	CCONJ
admet-881	142	4	danazol	danazol	ADJ
admet-881	142	5	are	be	AUX
admet-881	142	6	metabolized	metabolize	VERB
admet-881	142	7	in	in	ADP
admet-881	142	8	the	the	DET
admet-881	142	9	small	small	ADJ
admet-881	142	10	intestine	intestine	NOUN
admet-881	142	11	and	and	CCONJ
admet-881	142	12	liver	liver	NOUN
admet-881	142	13	by	by	ADP
admet-881	142	14	cyp3a4	cyp3a4	PROPN
admet-881	142	15	,	,	PUNCT
admet-881	142	16	where	where	SCONJ
admet-881	142	17	the	the	DET
admet-881	142	18	gut	gut	NOUN
admet-881	142	19	wall	wall	NOUN
admet-881	142	20	and	and	CCONJ
admet-881	142	21	liver	liver	VERB
admet-881	142	22	first	first	ADJ
admet-881	142	23	-	-	PUNCT
admet-881	142	24	pass	pass	NOUN
admet-881	142	25	extraction	extraction	NOUN
admet-881	142	26	might	might	AUX
admet-881	142	27	be	be	AUX
admet-881	142	28	affected	affect	VERB
admet-881	142	29	by	by	ADP
admet-881	142	30	differences	difference	NOUN
admet-881	142	31	in	in	ADP
admet-881	142	32	small	small	ADJ
admet-881	142	33	intestinal	intestinal	ADJ
admet-881	142	34	absorption	absorption	NOUN
admet-881	142	35	[	[	X
admet-881	142	36	66	66	NUM
admet-881	142	37	-	-	SYM
admet-881	142	38	68	68	NUM
admet-881	142	39	]	]	PUNCT
admet-881	142	40	.	.	PUNCT
admet-881	143	1	the	the	DET
admet-881	143	2	size	size	NOUN
admet-881	143	3	of	of	ADP
admet-881	143	4	the	the	DET
admet-881	143	5	nanoparticles	nanoparticle	NOUN
admet-881	143	6	of	of	ADP
admet-881	143	7	cyclosporine	cyclosporine	NOUN
admet-881	143	8	and	and	CCONJ
admet-881	143	9	danazol	danazol	ADJ
admet-881	143	10	used	use	VERB
admet-881	143	11	in	in	ADP
admet-881	143	12	the	the	DET
admet-881	143	13	experiments	experiment	NOUN
admet-881	143	14	discussed	discuss	VERB
admet-881	143	15	below	below	ADV
admet-881	143	16	was	be	AUX
admet-881	143	17	650	650	NUM
admet-881	143	18	and	and	CCONJ
admet-881	143	19	150	150	NUM
admet-881	143	20	nm	nm	NOUN
admet-881	143	21	,	,	PUNCT
admet-881	143	22	respectively	respectively	ADV
admet-881	143	23	.	.	PUNCT
admet-881	144	1	to	to	PART
admet-881	144	2	ensure	ensure	VERB
admet-881	144	3	that	that	SCONJ
admet-881	144	4	the	the	DET
admet-881	144	5	nanosuspension	nanosuspension	NOUN
admet-881	144	6	was	be	AUX
admet-881	144	7	homogenous	homogenous	ADJ
admet-881	144	8	and	and	CCONJ
admet-881	144	9	stabilized	stabilize	VERB
admet-881	144	10	,	,	PUNCT
admet-881	144	11	cyclosporine	cyclosporine	NOUN
admet-881	144	12	and	and	CCONJ
admet-881	144	13	danazol	danazol	ADJ
admet-881	144	14	were	be	AUX
admet-881	144	15	added	add	VERB
admet-881	144	16	to	to	ADP
admet-881	144	17	an	an	DET
admet-881	144	18	aqueous	aqueous	ADJ
admet-881	144	19	solution	solution	NOUN
admet-881	144	20	containing	contain	VERB
admet-881	144	21	small	small	ADJ
admet-881	144	22	amounts	amount	NOUN
admet-881	144	23	of	of	ADP
admet-881	144	24	water	water	NOUN
admet-881	144	25	-	-	PUNCT
admet-881	144	26	soluble	soluble	ADJ
admet-881	144	27	polymer	polymer	NOUN
admet-881	144	28	and	and	CCONJ
admet-881	144	29	surfactant	surfactant	NOUN
admet-881	144	30	as	as	ADP
admet-881	144	31	stabilizers	stabilizer	NOUN
admet-881	144	32	/	/	SYM
admet-881	144	33	dispersants	dispersant	NOUN
admet-881	144	34	(	(	PUNCT
admet-881	144	35	peg-4000	peg-4000	NOUN
admet-881	144	36	0.13	0.13	NUM
admet-881	144	37	mg	mg	PROPN
admet-881	144	38	/	/	SYM
admet-881	144	39	ml	ml	NOUN
admet-881	144	40	,	,	PUNCT
admet-881	144	41	monoolein	monoolein	ADJ
admet-881	144	42	4	4	NUM
admet-881	144	43	mg	mg	NUM
admet-881	144	44	/	/	SYM
admet-881	144	45	ml	ml	NOUN
admet-881	144	46	,	,	PUNCT
admet-881	144	47	sodium	sodium	NOUN
admet-881	144	48	taurocholate	taurocholate	NOUN
admet-881	144	49	20	20	NUM
admet-881	144	50	mg	mg	NUM
admet-881	144	51	/	/	SYM
admet-881	144	52	ml	ml	NOUN
admet-881	144	53	,	,	PUNCT
admet-881	144	54	oleic	oleic	NOUN
admet-881	144	55	acid	acid	PROPN
admet-881	144	56	20	20	NUM
admet-881	144	57	mg	mg	NUM
admet-881	144	58	/	/	SYM
admet-881	144	59	ml	ml	NOUN
admet-881	144	60	,	,	PUNCT
admet-881	144	61	and	and	CCONJ
admet-881	144	62	phosphatidylcholine	phosphatidylcholine	NOUN
admet-881	144	63	6	6	NUM
admet-881	144	64	mg	mg	NUM
admet-881	144	65	/	/	SYM
admet-881	144	66	ml	ml	NOUN
admet-881	144	67	)	)	PUNCT
admet-881	144	68	.	.	PUNCT
admet-881	145	1	both	both	DET
admet-881	145	2	model	model	NOUN
admet-881	145	3	drugs	drug	NOUN
admet-881	145	4	were	be	AUX
admet-881	145	5	single	single	ADJ
admet-881	145	6	-	-	PUNCT
admet-881	145	7	passed	pass	VERB
admet-881	145	8	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	145	9	h.	h.	PROPN
admet-881	145	10	lennernäs	lennernäs	PROPN
admet-881	145	11	et	et	PROPN
admet-881	145	12	al	al	PROPN
admet-881	145	13	.	.	PROPN
admet-881	145	14	admet	admet	PROPN
admet-881	145	15	&	&	CCONJ
admet-881	145	16	dmpk	dmpk	PROPN
admet-881	145	17	8(4	8(4	NOUN
admet-881	145	18	)	)	PUNCT
admet-881	145	19	(	(	PUNCT
admet-881	145	20	2020	2020	NUM
admet-881	145	21	)	)	PUNCT
admet-881	145	22	375	375	NUM
admet-881	145	23	-	-	SYM
admet-881	145	24	390	390	NUM
admet-881	145	25	382	382	NUM
admet-881	145	26	perfused	perfuse	VERB
admet-881	145	27	through	through	ADP
admet-881	145	28	pig	pig	NOUN
admet-881	145	29	jejunum	jejunum	PROPN
admet-881	145	30	in	in	ADP
admet-881	145	31	isotonic	isotonic	ADJ
admet-881	145	32	fluid	fluid	NOUN
admet-881	145	33	alone	alone	ADJ
admet-881	145	34	with	with	ADP
admet-881	145	35	and	and	CCONJ
admet-881	145	36	without	without	ADP
admet-881	145	37	a	a	DET
admet-881	145	38	p	p	NOUN
admet-881	145	39	-	-	PUNCT
admet-881	145	40	gp	gp	NOUN
admet-881	145	41	inhibitor	inhibitor	NOUN
admet-881	145	42	,	,	PUNCT
admet-881	145	43	and	and	CCONJ
admet-881	145	44	with	with	ADP
admet-881	145	45	dietary	dietary	ADJ
admet-881	145	46	and	and	CCONJ
admet-881	145	47	endogenous	endogenous	ADJ
admet-881	145	48	lipids	lipid	NOUN
admet-881	145	49	.	.	PUNCT
admet-881	146	1	to	to	PART
admet-881	146	2	determine	determine	VERB
admet-881	146	3	the	the	DET
admet-881	146	4	effect	effect	NOUN
admet-881	146	5	of	of	ADP
admet-881	146	6	food	food	NOUN
admet-881	146	7	on	on	ADP
admet-881	146	8	the	the	DET
admet-881	146	9	in	in	ADP
admet-881	146	10	vivo	vivo	ADJ
admet-881	146	11	dissolution	dissolution	NOUN
admet-881	146	12	of	of	ADP
admet-881	146	13	cyclosporine	cyclosporine	NOUN
admet-881	146	14	and	and	CCONJ
admet-881	146	15	danazol	danazol	ADJ
admet-881	146	16	,	,	PUNCT
admet-881	146	17	saturated	saturate	VERB
admet-881	146	18	drug	drug	NOUN
admet-881	146	19	solutions	solution	NOUN
admet-881	146	20	in	in	ADP
admet-881	146	21	isotonic	isotonic	ADJ
admet-881	146	22	fluid	fluid	NOUN
admet-881	146	23	containing	contain	VERB
admet-881	146	24	lipids	lipid	NOUN
admet-881	146	25	were	be	AUX
admet-881	146	26	also	also	ADV
admet-881	146	27	perfused	perfuse	VERB
admet-881	146	28	in	in	ADP
admet-881	146	29	pig	pig	PROPN
admet-881	146	30	.	.	PUNCT
admet-881	147	1	fenofibrate	fenofibrate	PROPN
admet-881	147	2	is	be	AUX
admet-881	147	3	mainly	mainly	ADV
admet-881	147	4	used	use	VERB
admet-881	147	5	for	for	ADP
admet-881	147	6	primary	primary	ADJ
admet-881	147	7	hypercholesterolemia	hypercholesterolemia	NOUN
admet-881	147	8	or	or	CCONJ
admet-881	147	9	mixed	mixed	ADJ
admet-881	147	10	dyslipidemia	dyslipidemia	NOUN
admet-881	147	11	.	.	PUNCT
admet-881	148	1	fenofibrate	fenofibrate	PROPN
admet-881	148	2	is	be	AUX
admet-881	148	3	a	a	DET
admet-881	148	4	low	low	ADJ
admet-881	148	5	molecular	molecular	ADJ
admet-881	148	6	mass	mass	NOUN
admet-881	148	7	(	(	PUNCT
admet-881	148	8	360.4	360.4	NUM
admet-881	148	9	da	da	NOUN
admet-881	148	10	)	)	PUNCT
admet-881	148	11	bcs	bcs	NOUN
admet-881	148	12	class	class	NOUN
admet-881	148	13	ii	ii	PROPN
admet-881	148	14	drug	drug	NOUN
admet-881	148	15	that	that	PRON
admet-881	148	16	is	be	AUX
admet-881	148	17	very	very	ADV
admet-881	148	18	lipophilic	lipophilic	ADJ
admet-881	148	19	(	(	PUNCT
admet-881	148	20	log	log	NOUN
admet-881	148	21	p	p	NOUN
admet-881	148	22	=	=	NOUN
admet-881	148	23	5.24	5.24	NUM
admet-881	148	24	)	)	PUNCT
admet-881	148	25	,	,	PUNCT
admet-881	148	26	with	with	SCONJ
admet-881	148	27	an	an	DET
admet-881	148	28	aqueous	aqueous	ADJ
admet-881	148	29	solubility	solubility	NOUN
admet-881	148	30	of	of	ADP
admet-881	148	31	<	<	X
admet-881	148	32	0.1	0.1	NUM
admet-881	148	33	mg	mg	NUM
admet-881	148	34	/	/	SYM
admet-881	148	35	ml	ml	NOUN
admet-881	148	36	.	.	PUNCT
admet-881	148	37	fenofibrate	fenofibrate	PROPN
admet-881	148	38	is	be	AUX
admet-881	148	39	an	an	DET
admet-881	148	40	ester	ester	NOUN
admet-881	148	41	of	of	ADP
admet-881	148	42	fenofibric	fenofibric	ADJ
admet-881	148	43	acid	acid	NOUN
admet-881	148	44	.	.	PUNCT
admet-881	149	1	after	after	ADP
admet-881	149	2	oral	oral	ADJ
admet-881	149	3	administration	administration	NOUN
admet-881	149	4	in	in	ADP
admet-881	149	5	humans	human	NOUN
admet-881	149	6	,	,	PUNCT
admet-881	149	7	it	it	PRON
admet-881	149	8	is	be	AUX
admet-881	149	9	completely	completely	ADV
admet-881	149	10	converted	convert	VERB
admet-881	149	11	to	to	ADP
admet-881	149	12	its	its	PRON
admet-881	149	13	active	active	ADJ
admet-881	149	14	metabolite	metabolite	NOUN
admet-881	149	15	,	,	PUNCT
admet-881	149	16	fenofibric	fenofibric	NOUN
admet-881	149	17	acid	acid	NOUN
admet-881	149	18	.	.	PUNCT
admet-881	150	1	fenofibric	fenofibric	NOUN
admet-881	150	2	acid	acid	NOUN
admet-881	150	3	and	and	CCONJ
admet-881	150	4	fenofibric	fenofibric	NOUN
admet-881	150	5	acid	acid	NOUN
admet-881	150	6	glucuronide	glucuronide	NOUN
admet-881	150	7	are	be	AUX
admet-881	150	8	then	then	ADV
admet-881	150	9	excreted	excrete	VERB
admet-881	150	10	into	into	ADP
admet-881	150	11	urine	urine	NOUN
admet-881	150	12	(	(	PUNCT
admet-881	150	13	60	60	NUM
admet-881	150	14	%	%	NOUN
admet-881	150	15	of	of	ADP
admet-881	150	16	the	the	DET
admet-881	150	17	dose	dose	NOUN
admet-881	150	18	)	)	PUNCT
admet-881	150	19	and	and	CCONJ
admet-881	150	20	feces	fece	NOUN
admet-881	150	21	(	(	PUNCT
admet-881	150	22	25	25	NUM
admet-881	150	23	%	%	NOUN
admet-881	150	24	)	)	PUNCT
admet-881	151	1	[	[	X
admet-881	151	2	69	69	NUM
admet-881	151	3	]	]	PUNCT
admet-881	151	4	.	.	PUNCT
admet-881	152	1	comparison	comparison	NOUN
admet-881	152	2	between	between	ADP
admet-881	152	3	microand	microand	NOUN
admet-881	152	4	nanosuspensions	nanosuspension	NOUN
admet-881	152	5	of	of	ADP
admet-881	152	6	bcs	bcs	NOUN
admet-881	152	7	class	class	NOUN
admet-881	152	8	ii	ii	PROPN
admet-881	152	9	drugs	drug	NOUN
admet-881	152	10	experimental	experimental	ADJ
admet-881	152	11	data	datum	NOUN
admet-881	152	12	and	and	CCONJ
admet-881	152	13	simulations	simulation	NOUN
admet-881	152	14	show	show	VERB
admet-881	152	15	that	that	SCONJ
admet-881	152	16	small	small	ADJ
admet-881	152	17	intestinal	intestinal	ADJ
admet-881	152	18	absorption	absorption	NOUN
admet-881	152	19	of	of	ADP
admet-881	152	20	larger	large	ADJ
admet-881	152	21	particles	particle	NOUN
admet-881	152	22	of	of	ADP
admet-881	152	23	danazol	danazol	ADJ
admet-881	152	24	(	(	PUNCT
admet-881	152	25	226	226	NUM
admet-881	152	26	µm	µm	NOUN
admet-881	152	27	)	)	PUNCT
admet-881	152	28	,	,	PUNCT
admet-881	152	29	griseofulvin	griseofulvin	NOUN
admet-881	152	30	(	(	PUNCT
admet-881	152	31	118	118	NUM
admet-881	152	32	µm	µm	NOUN
admet-881	152	33	)	)	PUNCT
admet-881	152	34	,	,	PUNCT
admet-881	152	35	and	and	CCONJ
admet-881	152	36	aprepitant	aprepitant	ADJ
admet-881	152	37	(	(	PUNCT
admet-881	152	38	26	26	NUM
admet-881	152	39	µm	µm	NOUN
admet-881	152	40	)	)	PUNCT
admet-881	152	41	,	,	PUNCT
admet-881	152	42	is	be	AUX
admet-881	152	43	dissolution	dissolution	ADJ
admet-881	152	44	rate	rate	NOUN
admet-881	152	45	-	-	PUNCT
admet-881	152	46	controlled	control	VERB
admet-881	152	47	[	[	X
admet-881	152	48	70	70	NUM
admet-881	152	49	]	]	PUNCT
admet-881	152	50	.	.	PUNCT
admet-881	153	1	takano	takano	PROPN
admet-881	153	2	et	et	PROPN
admet-881	153	3	al	al	PROPN
admet-881	153	4	.	.	PROPN
admet-881	153	5	also	also	ADV
admet-881	153	6	show	show	VERB
admet-881	153	7	that	that	PRON
admet-881	153	8	reduction	reduction	NOUN
admet-881	153	9	of	of	ADP
admet-881	153	10	particle	particle	NOUN
admet-881	153	11	size	size	NOUN
admet-881	153	12	increases	increase	VERB
admet-881	153	13	in	in	ADP
admet-881	153	14	vitro	vitro	X
admet-881	153	15	dissolution	dissolution	NOUN
admet-881	153	16	and	and	CCONJ
admet-881	153	17	improves	improve	VERB
admet-881	153	18	intestinal	intestinal	ADJ
admet-881	153	19	absorption	absorption	NOUN
admet-881	153	20	in	in	ADP
admet-881	153	21	dogs	dog	NOUN
admet-881	153	22	.	.	PUNCT
admet-881	154	1	increasing	increase	VERB
admet-881	154	2	the	the	DET
admet-881	154	3	dissolution	dissolution	NOUN
admet-881	154	4	rate	rate	NOUN
admet-881	154	5	by	by	ADP
admet-881	154	6	using	use	VERB
admet-881	154	7	of	of	ADP
admet-881	154	8	smaller	small	ADJ
admet-881	154	9	particles	particle	NOUN
admet-881	154	10	of	of	ADP
admet-881	154	11	these	these	DET
admet-881	154	12	three	three	NUM
admet-881	154	13	selected	select	VERB
admet-881	154	14	model	model	NOUN
admet-881	154	15	drugs	drug	NOUN
admet-881	154	16	does	do	AUX
admet-881	154	17	not	not	PART
admet-881	154	18	improve	improve	VERB
admet-881	154	19	their	their	PRON
admet-881	154	20	small	small	ADJ
admet-881	154	21	intestinal	intestinal	ADJ
admet-881	154	22	absorption	absorption	NOUN
admet-881	154	23	because	because	SCONJ
admet-881	154	24	their	their	PRON
admet-881	154	25	absorption	absorption	NOUN
admet-881	154	26	is	be	AUX
admet-881	154	27	limited	limit	VERB
admet-881	154	28	by	by	ADP
admet-881	154	29	their	their	PRON
admet-881	154	30	solubility	solubility	NOUN
admet-881	154	31	during	during	ADP
admet-881	154	32	non	non	ADJ
admet-881	154	33	-	-	ADJ
admet-881	154	34	sink	sink	ADJ
admet-881	154	35	luminal	luminal	ADJ
admet-881	154	36	conditions	condition	NOUN
admet-881	154	37	[	[	X
admet-881	154	38	70	70	NUM
admet-881	154	39	]	]	PUNCT
admet-881	154	40	.	.	PUNCT
admet-881	155	1	however	however	ADV
admet-881	155	2	,	,	PUNCT
admet-881	155	3	for	for	ADP
admet-881	155	4	some	some	DET
admet-881	155	5	drug	drug	NOUN
admet-881	155	6	formulated	formulate	VERB
admet-881	155	7	as	as	ADP
admet-881	155	8	nanoparticles	nanoparticle	NOUN
admet-881	155	9	in	in	ADP
admet-881	155	10	the	the	DET
admet-881	155	11	range	range	NOUN
admet-881	155	12	of	of	ADP
admet-881	155	13	50	50	NUM
admet-881	155	14	–	–	PUNCT
admet-881	155	15	200	200	NUM
admet-881	155	16	nm	nm	NOUN
admet-881	155	17	,	,	PUNCT
admet-881	155	18	the	the	DET
admet-881	155	19	absorption	absorption	NOUN
admet-881	155	20	and	and	CCONJ
admet-881	155	21	plasma	plasma	NOUN
admet-881	155	22	exposure	exposure	NOUN
admet-881	155	23	increased	increase	VERB
admet-881	155	24	.	.	PUNCT
admet-881	156	1	the	the	DET
admet-881	156	2	increased	increase	VERB
admet-881	156	3	absorption	absorption	NOUN
admet-881	156	4	rate	rate	NOUN
admet-881	156	5	is	be	AUX
admet-881	156	6	often	often	ADV
admet-881	156	7	explained	explain	VERB
admet-881	156	8	by	by	ADP
admet-881	156	9	enhanced	enhanced	ADJ
admet-881	156	10	drug	drug	NOUN
admet-881	156	11	dissolution	dissolution	NOUN
admet-881	156	12	rate	rate	NOUN
admet-881	156	13	[	[	X
admet-881	156	14	28,34,71	28,34,71	NUM
admet-881	156	15	]	]	PUNCT
admet-881	156	16	.	.	PUNCT
admet-881	157	1	these	these	DET
admet-881	157	2	differences	difference	NOUN
admet-881	157	3	in	in	ADP
admet-881	157	4	experimental	experimental	ADJ
admet-881	157	5	in	in	ADP
admet-881	157	6	vivo	vivo	ADJ
admet-881	157	7	data	datum	NOUN
admet-881	157	8	and	and	CCONJ
admet-881	157	9	their	their	PRON
admet-881	157	10	interpretation	interpretation	NOUN
admet-881	157	11	will	will	AUX
admet-881	157	12	be	be	AUX
admet-881	157	13	discussed	discuss	VERB
admet-881	157	14	below	below	ADV
admet-881	157	15	.	.	PUNCT
admet-881	158	1	the	the	DET
admet-881	158	2	intestinal	intestinal	ADJ
admet-881	158	3	absorption	absorption	NOUN
admet-881	158	4	rate	rate	NOUN
admet-881	158	5	of	of	ADP
admet-881	158	6	aprepitant	aprepitant	ADJ
admet-881	158	7	increases	increase	NOUN
admet-881	158	8	by	by	ADP
admet-881	158	9	increasing	increase	VERB
admet-881	158	10	the	the	DET
admet-881	158	11	concentration	concentration	NOUN
admet-881	158	12	of	of	ADP
admet-881	158	13	nanoparticles	nanoparticle	NOUN
admet-881	158	14	(	(	PUNCT
admet-881	158	15	200	200	NUM
admet-881	158	16	µm	µm	NOUN
admet-881	158	17	versus	versus	ADP
admet-881	158	18	20	20	NUM
admet-881	158	19	µm	µm	NOUN
admet-881	158	20	)	)	PUNCT
admet-881	158	21	in	in	ADP
admet-881	158	22	the	the	DET
admet-881	158	23	perfusion	perfusion	NOUN
admet-881	158	24	suspension	suspension	NOUN
admet-881	158	25	passed	pass	VERB
admet-881	158	26	along	along	ADP
admet-881	158	27	the	the	DET
admet-881	158	28	small	small	ADJ
admet-881	158	29	intestine	intestine	NOUN
admet-881	158	30	segment	segment	NOUN
admet-881	158	31	in	in	ADP
admet-881	158	32	the	the	DET
admet-881	158	33	rat	rat	NOUN
admet-881	158	34	spip	spip	NOUN
admet-881	158	35	model	model	NOUN
admet-881	158	36	[	[	X
admet-881	158	37	5	5	NUM
admet-881	158	38	]	]	PUNCT
admet-881	158	39	.	.	PUNCT
admet-881	159	1	aprepitant	aprepitant	PROPN
admet-881	159	2	permeates	permeate	VERB
admet-881	159	3	the	the	DET
admet-881	159	4	apical	apical	ADJ
admet-881	159	5	membrane	membrane	NOUN
admet-881	159	6	as	as	ADP
admet-881	159	7	a	a	DET
admet-881	159	8	monomer	monomer	NOUN
admet-881	159	9	very	very	ADV
admet-881	159	10	swiftly	swiftly	ADV
admet-881	159	11	and	and	CCONJ
admet-881	159	12	has	have	VERB
admet-881	159	13	a	a	DET
admet-881	159	14	small	small	ADJ
admet-881	159	15	intestinal	intestinal	ADJ
admet-881	159	16	peff	peff	NOUN
admet-881	159	17	of	of	ADP
admet-881	159	18	1.7	1.7	NUM
admet-881	159	19	·	·	SYM
admet-881	159	20	10	10	NUM
admet-881	159	21	-	-	SYM
admet-881	159	22	4	4	NUM
admet-881	159	23	cm	cm	NOUN
admet-881	159	24	/	/	SYM
admet-881	159	25	s.	s.	PROPN
admet-881	159	26	both	both	CCONJ
admet-881	159	27	the	the	DET
admet-881	159	28	drifting	drifting	NOUN
admet-881	159	29	and	and	CCONJ
admet-881	159	30	deposition	deposition	NOUN
admet-881	159	31	of	of	ADP
admet-881	159	32	nanoparticles	nanoparticle	NOUN
admet-881	159	33	with	with	ADP
admet-881	159	34	aprepitant	aprepitant	ADJ
admet-881	159	35	in	in	ADP
admet-881	159	36	the	the	DET
admet-881	159	37	abl	abl	PROPN
admet-881	159	38	,	,	PUNCT
admet-881	159	39	as	as	ADV
admet-881	159	40	well	well	ADV
admet-881	159	41	as	as	ADP
admet-881	159	42	colloidal	colloidal	NOUN
admet-881	159	43	structures	structure	NOUN
admet-881	159	44	,	,	PUNCT
admet-881	159	45	may	may	AUX
admet-881	159	46	contribute	contribute	VERB
admet-881	159	47	to	to	ADP
admet-881	159	48	an	an	DET
admet-881	159	49	increase	increase	NOUN
admet-881	159	50	in	in	ADP
admet-881	159	51	intestinal	intestinal	ADJ
admet-881	159	52	absorption	absorption	NOUN
admet-881	159	53	.	.	PUNCT
admet-881	160	1	absorption	absorption	NOUN
admet-881	160	2	of	of	ADP
admet-881	160	3	nanoand	nanoand	PROPN
admet-881	160	4	microsuspensions	microsuspension	NOUN
admet-881	160	5	has	have	AUX
admet-881	160	6	been	be	AUX
admet-881	160	7	compared	compare	VERB
admet-881	160	8	in	in	ADP
admet-881	160	9	the	the	DET
admet-881	160	10	rat	rat	NOUN
admet-881	160	11	spip	spip	NOUN
admet-881	160	12	model	model	NOUN
admet-881	160	13	when	when	SCONJ
admet-881	160	14	the	the	DET
admet-881	160	15	small	small	ADJ
admet-881	160	16	intestinal	intestinal	ADJ
admet-881	160	17	segment	segment	NOUN
admet-881	160	18	was	be	AUX
admet-881	160	19	perfused	perfuse	VERB
admet-881	160	20	with	with	ADP
admet-881	160	21	buffer	buffer	NOUN
admet-881	160	22	,	,	PUNCT
admet-881	160	23	fassif	fassif	NOUN
admet-881	160	24	,	,	PUNCT
admet-881	160	25	and	and	CCONJ
admet-881	160	26	fessif	fessif	NOUN
admet-881	160	27	.	.	PUNCT
admet-881	161	1	in	in	ADP
admet-881	161	2	with	with	ADP
admet-881	161	3	single	single	ADJ
admet-881	161	4	-	-	PUNCT
admet-881	161	5	pass	pass	NOUN
admet-881	161	6	perfusions	perfusion	NOUN
admet-881	161	7	of	of	ADP
admet-881	161	8	jejunum	jejunum	NOUN
admet-881	161	9	,	,	PUNCT
admet-881	161	10	the	the	DET
admet-881	161	11	plasma	plasma	NOUN
admet-881	161	12	concentration	concentration	NOUN
admet-881	161	13	time	time	NOUN
admet-881	161	14	–	–	PUNCT
admet-881	161	15	curves	curve	NOUN
admet-881	161	16	clearly	clearly	ADV
admet-881	161	17	show	show	VERB
admet-881	161	18	that	that	SCONJ
admet-881	161	19	fed	fed	PROPN
admet-881	161	20	conditions	condition	NOUN
admet-881	161	21	,	,	PUNCT
admet-881	161	22	i.e.	i.e.	X
admet-881	161	23	fessif	fessif	X
admet-881	161	24	,	,	PUNCT
admet-881	161	25	increase	increase	VERB
admet-881	161	26	the	the	DET
admet-881	161	27	intestinal	intestinal	ADJ
admet-881	161	28	absorption	absorption	NOUN
admet-881	161	29	of	of	ADP
admet-881	161	30	aprepitant	aprepitant	ADJ
admet-881	161	31	as	as	ADP
admet-881	161	32	microsuspensions	microsuspension	NOUN
admet-881	161	33	,	,	PUNCT
admet-881	161	34	but	but	CCONJ
admet-881	161	35	not	not	PART
admet-881	161	36	as	as	ADP
admet-881	161	37	nanosuspensions	nanosuspension	NOUN
admet-881	161	38	.	.	PUNCT
admet-881	162	1	this	this	DET
admet-881	162	2	difference	difference	NOUN
admet-881	162	3	is	be	AUX
admet-881	162	4	in	in	ADP
admet-881	162	5	line	line	NOUN
admet-881	162	6	with	with	ADP
admet-881	162	7	previous	previous	ADJ
admet-881	162	8	data	datum	NOUN
admet-881	162	9	from	from	ADP
admet-881	162	10	both	both	DET
admet-881	162	11	dog	dog	NOUN
admet-881	162	12	and	and	CCONJ
admet-881	162	13	human	human	NOUN
admet-881	162	14	,	,	PUNCT
admet-881	162	15	in	in	ADP
admet-881	162	16	which	which	PRON
admet-881	162	17	nanosuspensions	nanosuspension	NOUN
admet-881	162	18	seem	seem	VERB
admet-881	162	19	to	to	PART
admet-881	162	20	prevent	prevent	VERB
admet-881	162	21	variation	variation	NOUN
admet-881	162	22	in	in	ADP
admet-881	162	23	plasma	plasma	NOUN
admet-881	162	24	exposure	exposure	NOUN
admet-881	162	25	between	between	ADP
admet-881	162	26	different	different	ADJ
admet-881	162	27	prandial	prandial	ADJ
admet-881	162	28	states	state	NOUN
admet-881	162	29	,	,	PUNCT
admet-881	162	30	while	while	SCONJ
admet-881	162	31	microsuspensions	microsuspension	NOUN
admet-881	162	32	show	show	VERB
admet-881	162	33	significant	significant	ADJ
admet-881	162	34	food	food	NOUN
admet-881	162	35	-	-	PUNCT
admet-881	162	36	effects	effect	NOUN
admet-881	162	37	[	[	X
admet-881	162	38	72	72	NUM
admet-881	162	39	-	-	SYM
admet-881	162	40	75	75	NUM
admet-881	162	41	]	]	PUNCT
admet-881	162	42	.	.	PUNCT
admet-881	163	1	the	the	DET
admet-881	163	2	mucus	mucus	NOUN
admet-881	163	3	layer	layer	NOUN
admet-881	163	4	also	also	ADV
admet-881	163	5	influences	influence	VERB
admet-881	163	6	absorption	absorption	NOUN
admet-881	163	7	of	of	ADP
admet-881	163	8	drugs	drug	NOUN
admet-881	163	9	delivered	deliver	VERB
admet-881	163	10	orally	orally	ADV
admet-881	163	11	as	as	ADP
admet-881	163	12	nanoparticles	nanoparticle	NOUN
admet-881	163	13	[	[	X
admet-881	163	14	76	76	NUM
admet-881	163	15	]	]	X
admet-881	163	16	.	.	PUNCT
admet-881	164	1	for	for	ADP
admet-881	164	2	example	example	NOUN
admet-881	164	3	,	,	PUNCT
admet-881	164	4	the	the	DET
admet-881	164	5	hydrophobicity	hydrophobicity	NOUN
admet-881	164	6	,	,	PUNCT
admet-881	164	7	electrostatic	electrostatic	ADJ
admet-881	164	8	properties	property	NOUN
admet-881	164	9	,	,	PUNCT
admet-881	164	10	and	and	CCONJ
admet-881	164	11	steric	steric	ADJ
admet-881	164	12	hindrance	hindrance	NOUN
admet-881	164	13	,	,	PUNCT
admet-881	164	14	of	of	ADP
admet-881	164	15	mucus	mucus	NOUN
admet-881	164	16	are	be	AUX
admet-881	164	17	key	key	ADJ
admet-881	164	18	feature	feature	NOUN
admet-881	164	19	that	that	PRON
admet-881	164	20	prevents	prevent	VERB
admet-881	164	21	the	the	DET
admet-881	164	22	hydrophilic	hydrophilic	ADJ
admet-881	164	23	pancreatic	pancreatic	ADJ
admet-881	164	24	proteases	protease	NOUN
admet-881	164	25	from	from	ADP
admet-881	164	26	acting	act	VERB
admet-881	164	27	on	on	ADP
admet-881	164	28	,	,	PUNCT
admet-881	164	29	and	and	CCONJ
admet-881	164	30	thereby	thereby	ADV
admet-881	164	31	injuring	injure	VERB
admet-881	164	32	,	,	PUNCT
admet-881	164	33	the	the	DET
admet-881	164	34	intestinal	intestinal	ADJ
admet-881	164	35	epithelium	epithelium	NOUN
admet-881	165	1	[	[	X
admet-881	165	2	77	77	NUM
admet-881	165	3	]	]	PUNCT
admet-881	165	4	.	.	PUNCT
admet-881	166	1	to	to	PART
admet-881	166	2	quantify	quantify	VERB
admet-881	166	3	the	the	DET
admet-881	166	4	jejunal	jejunal	ADJ
admet-881	166	5	flux	flux	NOUN
admet-881	166	6	of	of	ADP
admet-881	166	7	aprepitant	aprepitant	ADJ
admet-881	166	8	across	across	ADP
admet-881	166	9	the	the	DET
admet-881	166	10	enterocytes	enterocyte	NOUN
admet-881	166	11	,	,	PUNCT
admet-881	166	12	japp	japp	PROPN
admet-881	166	13	was	be	AUX
admet-881	166	14	calculated	calculate	VERB
admet-881	166	15	according	accord	VERB
admet-881	166	16	to	to	ADP
admet-881	166	17	eq	eq	PROPN
admet-881	166	18	.	.	PROPN
admet-881	166	19	4	4	NUM
admet-881	166	20	(	(	PUNCT
admet-881	166	21	table	table	NOUN
admet-881	166	22	3	3	NUM
admet-881	166	23	)	)	PUNCT
admet-881	166	24	.	.	PUNCT
admet-881	167	1	there	there	PRON
admet-881	167	2	were	be	VERB
admet-881	167	3	no	no	DET
admet-881	167	4	significant	significant	ADJ
admet-881	167	5	differences	difference	NOUN
admet-881	167	6	for	for	ADP
admet-881	167	7	microand	microand	NOUN
admet-881	167	8	nanosuspensions	nanosuspension	NOUN
admet-881	167	9	,	,	PUNCT
admet-881	167	10	but	but	CCONJ
admet-881	167	11	a	a	DET
admet-881	167	12	large	large	ADJ
admet-881	167	13	,	,	PUNCT
admet-881	167	14	albeit	albeit	SCONJ
admet-881	167	15	non	non	ADJ
admet-881	167	16	-	-	ADJ
admet-881	167	17	significant	significant	ADJ
admet-881	167	18	one	one	NOUN
admet-881	167	19	,	,	PUNCT
admet-881	167	20	for	for	ADP
admet-881	167	21	the	the	DET
admet-881	167	22	microsuspensions	microsuspension	NOUN
admet-881	167	23	in	in	ADP
admet-881	167	24	fessif	fessif	NOUN
admet-881	167	25	compared	compare	VERB
admet-881	167	26	to	to	PART
admet-881	167	27	buffer	buffer	VERB
admet-881	167	28	and	and	CCONJ
admet-881	167	29	fassif	fassif	NOUN
admet-881	167	30	(	(	PUNCT
admet-881	167	31	64	64	NUM
admet-881	167	32	and	and	CCONJ
admet-881	167	33	4.8	4.8	NUM
admet-881	167	34	times	time	NOUN
admet-881	167	35	higher	high	ADJ
admet-881	167	36	,	,	PUNCT
admet-881	167	37	respectively	respectively	ADV
admet-881	167	38	)	)	PUNCT
admet-881	167	39	.	.	PUNCT
admet-881	168	1	for	for	ADP
admet-881	168	2	the	the	DET
admet-881	168	3	nanosuspensions	nanosuspension	NOUN
admet-881	168	4	,	,	PUNCT
admet-881	168	5	the	the	DET
admet-881	168	6	japp	japp	NOUN
admet-881	168	7	were	be	AUX
admet-881	168	8	all	all	ADV
admet-881	168	9	within	within	ADP
admet-881	168	10	a	a	DET
admet-881	168	11	1.6	1.6	NUM
admet-881	168	12	-	-	ADJ
admet-881	168	13	fold	fold	ADJ
admet-881	168	14	range	range	NOUN
admet-881	168	15	,	,	PUNCT
admet-881	168	16	reiterating	reiterate	VERB
admet-881	168	17	the	the	DET
admet-881	168	18	effective	effective	ADJ
admet-881	168	19	elimination	elimination	NOUN
admet-881	168	20	of	of	ADP
admet-881	168	21	a	a	DET
admet-881	168	22	luminal	luminal	ADJ
admet-881	168	23	food	food	NOUN
admet-881	168	24	effect	effect	NOUN
admet-881	168	25	by	by	ADP
admet-881	168	26	the	the	DET
admet-881	168	27	nanoformulations	nanoformulation	NOUN
admet-881	168	28	.	.	PUNCT
admet-881	169	1	the	the	DET
admet-881	169	2	high	high	ADJ
admet-881	169	3	variability	variability	NOUN
admet-881	169	4	of	of	ADP
admet-881	169	5	the	the	DET
admet-881	169	6	data	datum	NOUN
admet-881	169	7	in	in	ADP
admet-881	169	8	this	this	DET
admet-881	169	9	paper	paper	NOUN
admet-881	169	10	demonstrates	demonstrate	VERB
admet-881	169	11	that	that	SCONJ
admet-881	169	12	studies	study	NOUN
admet-881	169	13	with	with	ADP
admet-881	169	14	more	more	ADJ
admet-881	169	15	animals	animal	NOUN
admet-881	169	16	are	be	AUX
admet-881	169	17	needed	need	VERB
admet-881	169	18	to	to	PART
admet-881	169	19	verify	verify	VERB
admet-881	169	20	these	these	DET
admet-881	169	21	observed	observe	VERB
admet-881	169	22	trends	trend	NOUN
admet-881	169	23	for	for	ADP
admet-881	169	24	nanoand	nanoand	NOUN
admet-881	169	25	microsuspensions	microsuspension	NOUN
admet-881	169	26	(	(	PUNCT
admet-881	169	27	table	table	NOUN
admet-881	169	28	3	3	NUM
admet-881	169	29	)	)	PUNCT
admet-881	169	30	.	.	PUNCT
admet-881	170	1	admet	admet	PROPN
admet-881	170	2	&	&	CCONJ
admet-881	170	3	dmpk	dmpk	PROPN
admet-881	170	4	8(4	8(4	NOUN
admet-881	170	5	)	)	PUNCT
admet-881	170	6	(	(	PUNCT
admet-881	170	7	2020	2020	NUM
admet-881	170	8	)	)	PUNCT
admet-881	170	9	375	375	NUM
admet-881	170	10	-	-	SYM
admet-881	170	11	390	390	NUM
admet-881	170	12	intestinal	intestinal	ADJ
admet-881	170	13	absorption	absorption	NOUN
admet-881	170	14	of	of	ADP
admet-881	170	15	bcs	bcs	NOUN
admet-881	170	16	class	class	NOUN
admet-881	170	17	ii	ii	PROPN
admet-881	170	18	drugs	drug	NOUN
admet-881	170	19	nanoparticles	nanoparticle	NOUN
admet-881	170	20	doi	doi	NOUN
admet-881	170	21	:	:	PUNCT
admet-881	170	22	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	170	23	383	383	NUM
admet-881	170	24	table	table	NOUN
admet-881	170	25	3	3	NUM
admet-881	170	26	.	.	PUNCT
admet-881	170	27	historical	historical	ADJ
admet-881	170	28	in	in	ADP
admet-881	170	29	vivo	vivo	ADJ
admet-881	170	30	absorption	absorption	NOUN
admet-881	170	31	flux	flux	NOUN
admet-881	170	32	(	(	PUNCT
admet-881	170	33	japp	japp	PROPN
admet-881	170	34	)	)	PUNCT
admet-881	170	35	(	(	PUNCT
admet-881	170	36	sd	sd	NOUN
admet-881	170	37	)	)	PUNCT
admet-881	170	38	for	for	ADP
admet-881	170	39	aprepitant	aprepitant	ADJ
admet-881	170	40	nanoand	nanoand	NOUN
admet-881	170	41	microsuspensions	microsuspension	NOUN
admet-881	170	42	determined	determine	VERB
admet-881	170	43	in	in	ADP
admet-881	170	44	the	the	DET
admet-881	170	45	jejunum	jejunum	NOUN
admet-881	170	46	of	of	ADP
admet-881	170	47	the	the	DET
admet-881	170	48	single	single	ADJ
admet-881	170	49	-	-	PUNCT
admet-881	170	50	pass	pass	NOUN
admet-881	170	51	perfused	perfuse	VERB
admet-881	170	52	rat	rat	NOUN
admet-881	170	53	reported	report	VERB
admet-881	170	54	by	by	ADP
admet-881	170	55	roos	roo	NOUN
admet-881	170	56	et	et	PROPN
admet-881	170	57	al	al	PROPN
admet-881	170	58	.	.	PROPN
admet-881	170	59	2018	2018	NUM
admet-881	171	1	[	[	X
admet-881	171	2	78	78	NUM
admet-881	171	3	]	]	PUNCT
admet-881	171	4	.	.	PUNCT
admet-881	172	1	media	medium	NOUN
admet-881	172	2	flux	flux	NOUN
admet-881	172	3	(	(	PUNCT
admet-881	172	4	×	×	PROPN
admet-881	172	5	10	10	NUM
admet-881	172	6	-3	-3	PUNCT
admet-881	172	7	µmol	µmol	ADV
admet-881	172	8	/	/	SYM
admet-881	172	9	(	(	PUNCT
admet-881	172	10	hr	hr	NOUN
admet-881	172	11	×	×	NOUN
admet-881	172	12	cm	cm	NOUN
admet-881	172	13	2	2	NUM
admet-881	172	14	)	)	PUNCT
admet-881	172	15	)	)	PUNCT
admet-881	172	16	nanosuspension	nanosuspension	NOUN
admet-881	172	17	microsuspension	microsuspension	NOUN
admet-881	172	18	buffer	buffer	VERB
admet-881	172	19	2.91	2.91	NUM
admet-881	172	20	(	(	PUNCT
admet-881	172	21	1.02	1.02	NUM
admet-881	172	22	)	)	PUNCT
admet-881	172	23	0.104	0.104	NUM
admet-881	172	24	(	(	PUNCT
admet-881	172	25	0.081	0.081	NUM
admet-881	172	26	)	)	PUNCT
admet-881	172	27	fassif	fassif	VERB
admet-881	172	28	3.57	3.57	NUM
admet-881	172	29	(	(	PUNCT
admet-881	172	30	1.97	1.97	NUM
admet-881	172	31	)	)	PUNCT
admet-881	172	32	1.58	1.58	NUM
admet-881	172	33	(	(	PUNCT
admet-881	172	34	2.10	2.10	NUM
admet-881	172	35	)	)	PUNCT
admet-881	172	36	fessif	fessif	NOUN
admet-881	172	37	2.25	2.25	NUM
admet-881	172	38	(	(	PUNCT
admet-881	172	39	1.69	1.69	NUM
admet-881	172	40	)	)	PUNCT
admet-881	172	41	6.63	6.63	NUM
admet-881	172	42	(	(	PUNCT
admet-881	172	43	7.32	7.32	NUM
admet-881	172	44	)	)	PUNCT
admet-881	172	45	in	in	ADP
admet-881	172	46	vivo	vivo	ADJ
admet-881	172	47	absorption	absorption	NOUN
admet-881	172	48	of	of	ADP
admet-881	172	49	bcs	bcs	NOUN
admet-881	172	50	class	class	NOUN
admet-881	172	51	ii	ii	NOUN
admet-881	172	52	drugs	drug	NOUN
admet-881	172	53	in	in	ADP
admet-881	172	54	nanoparticles	nanoparticle	NOUN
admet-881	172	55	at	at	ADP
admet-881	172	56	different	different	ADJ
admet-881	172	57	luminal	luminal	ADJ
admet-881	172	58	conditions	condition	NOUN
admet-881	172	59	danazol	danazol	ADJ
admet-881	172	60	and	and	CCONJ
admet-881	172	61	cyclosporine	cyclosporine	ADJ
admet-881	172	62	intestinal	intestinal	ADJ
admet-881	172	63	absorption	absorption	NOUN
admet-881	172	64	mechanisms	mechanism	NOUN
admet-881	172	65	have	have	AUX
admet-881	172	66	been	be	AUX
admet-881	172	67	investigated	investigate	VERB
admet-881	172	68	in	in	ADP
admet-881	172	69	fed	fed	PROPN
admet-881	172	70	and	and	CCONJ
admet-881	172	71	fasted	fast	VERB
admet-881	172	72	states	state	NOUN
admet-881	172	73	in	in	ADP
admet-881	172	74	a	a	DET
admet-881	172	75	pig	pig	NOUN
admet-881	172	76	spip	spip	NOUN
admet-881	172	77	model	model	NOUN
admet-881	172	78	for	for	ADP
admet-881	172	79	low	low	ADJ
admet-881	172	80	solubility	solubility	NOUN
admet-881	172	81	apis	api	VERB
admet-881	172	82	as	as	ADP
admet-881	172	83	monomers	monomer	NOUN
admet-881	172	84	or	or	CCONJ
admet-881	172	85	nanoparticles	nanoparticle	NOUN
admet-881	172	86	.	.	PUNCT
admet-881	173	1	nanoparticle	nanoparticle	NOUN
admet-881	173	2	suspensions	suspension	NOUN
admet-881	173	3	of	of	ADP
admet-881	173	4	two	two	NUM
admet-881	173	5	bcs	bcs	NOUN
admet-881	173	6	class	class	NOUN
admet-881	173	7	ii	ii	PROPN
admet-881	173	8	model	model	NOUN
admet-881	173	9	drugs	drug	NOUN
admet-881	173	10	,	,	PUNCT
admet-881	173	11	danazol	danazol	ADJ
admet-881	173	12	and	and	CCONJ
admet-881	173	13	cyclosporine	cyclosporine	ADJ
admet-881	173	14	(	(	PUNCT
admet-881	173	15	cya	cya	NOUN
admet-881	173	16	)	)	PUNCT
admet-881	173	17	,	,	PUNCT
admet-881	173	18	were	be	AUX
admet-881	173	19	single	single	ADJ
admet-881	173	20	-	-	PUNCT
admet-881	173	21	pass	pass	NOUN
admet-881	173	22	perfused	perfuse	VERB
admet-881	173	23	through	through	ADP
admet-881	173	24	the	the	DET
admet-881	173	25	pig	pig	NOUN
admet-881	173	26	jejunum	jejunum	NOUN
admet-881	173	27	in	in	ADP
admet-881	173	28	isotonic	isotonic	ADJ
admet-881	173	29	buffer	buffer	NOUN
admet-881	173	30	alone	alone	ADV
admet-881	173	31	(	(	PUNCT
admet-881	173	32	control	control	NOUN
admet-881	173	33	)	)	PUNCT
admet-881	173	34	and	and	CCONJ
admet-881	173	35	isotonic	isotonic	ADJ
admet-881	173	36	buffer	buffer	NOUN
admet-881	173	37	with	with	ADP
admet-881	173	38	verapamil	verapamil	NOUN
admet-881	173	39	,	,	PUNCT
admet-881	173	40	a	a	DET
admet-881	173	41	p	p	NOUN
admet-881	173	42	-	-	PUNCT
admet-881	173	43	glycoprotein	glycoprotein	NOUN
admet-881	173	44	(	(	PUNCT
admet-881	173	45	p	p	NOUN
admet-881	173	46	-	-	PUNCT
admet-881	173	47	gp	gp	NOUN
admet-881	173	48	)	)	PUNCT
admet-881	173	49	inhibitor	inhibitor	NOUN
admet-881	173	50	,	,	PUNCT
admet-881	173	51	or	or	CCONJ
admet-881	173	52	in	in	ADP
admet-881	173	53	isotonic	isotonic	ADJ
admet-881	173	54	buffer	buffer	NOUN
admet-881	173	55	containing	contain	VERB
admet-881	173	56	dietary	dietary	ADJ
admet-881	173	57	and	and	CCONJ
admet-881	173	58	intestinal	intestinal	ADJ
admet-881	173	59	lipids	lipid	NOUN
admet-881	173	60	.	.	PUNCT
admet-881	174	1	co	co	NOUN
admet-881	175	1	-	-	NOUN
admet-881	175	2	administration	administration	NOUN
admet-881	175	3	of	of	ADP
admet-881	175	4	cya	cya	NOUN
admet-881	175	5	and	and	CCONJ
admet-881	175	6	verapamil	verapamil	NOUN
admet-881	175	7	increased	increase	VERB
admet-881	175	8	the	the	DET
admet-881	175	9	jejunal	jejunal	ADJ
admet-881	175	10	peff	peff	PROPN
admet-881	175	11	of	of	ADP
admet-881	175	12	cya	cya	NOUN
admet-881	175	13	from	from	ADP
admet-881	175	14	0.63	0.63	NUM
admet-881	175	15	±	±	NUM
admet-881	175	16	0.05	0.05	NUM
admet-881	175	17	·	·	PUNCT
admet-881	175	18	10	10	NUM
admet-881	175	19	-	-	SYM
admet-881	175	20	4	4	NUM
admet-881	175	21	cm	cm	NOUN
admet-881	175	22	/	/	SYM
admet-881	175	23	s	s	PROPN
admet-881	175	24	to	to	ADP
admet-881	175	25	1.01	1.01	NUM
admet-881	175	26	±	±	NUM
admet-881	175	27	0.09	0.09	NUM
admet-881	175	28	·	·	SYM
admet-881	175	29	10	10	NUM
admet-881	175	30	-	-	SYM
admet-881	175	31	4	4	NUM
admet-881	175	32	cm	cm	NOUN
admet-881	175	33	/	/	SYM
admet-881	175	34	s	s	PART
admet-881	176	1	[	[	X
admet-881	176	2	55	55	NUM
admet-881	176	3	]	]	PUNCT
admet-881	176	4	.	.	PUNCT
admet-881	177	1	the	the	DET
admet-881	177	2	human	human	ADJ
admet-881	177	3	jejunal	jejunal	ADJ
admet-881	177	4	peff	peff	PROPN
admet-881	177	5	for	for	ADP
admet-881	177	6	cya	cya	NOUN
admet-881	177	7	was	be	AUX
admet-881	177	8	1.65	1.65	NUM
admet-881	177	9	±	±	NUM
admet-881	177	10	0.53	0.53	NUM
admet-881	177	11	·	·	PUNCT
admet-881	177	12	10	10	NUM
admet-881	177	13	-	-	SYM
admet-881	177	14	4	4	NUM
admet-881	177	15	cm	cm	NUM
admet-881	177	16	/	/	SYM
admet-881	177	17	s	s	PROPN
admet-881	177	18	,	,	PUNCT
admet-881	177	19	when	when	SCONJ
admet-881	177	20	determined	determine	VERB
admet-881	177	21	with	with	ADP
admet-881	177	22	the	the	DET
admet-881	177	23	perfusion	perfusion	NOUN
admet-881	177	24	method	method	NOUN
admet-881	177	25	,	,	PUNCT
admet-881	177	26	which	which	PRON
admet-881	177	27	classifies	classify	VERB
admet-881	177	28	cya	cya	NOUN
admet-881	177	29	as	as	ADP
admet-881	177	30	a	a	DET
admet-881	177	31	low	low	ADJ
admet-881	177	32	solubility	solubility	NOUN
admet-881	177	33	-	-	PUNCT
admet-881	177	34	high	high	ADJ
admet-881	177	35	permeability	permeability	NOUN
admet-881	177	36	class	class	NOUN
admet-881	177	37	ii	ii	PROPN
admet-881	177	38	bcs	bcs	NOUN
admet-881	177	39	drug	drug	NOUN
admet-881	177	40	.	.	PUNCT
admet-881	178	1	cya	cya	NOUN
admet-881	178	2	is	be	AUX
admet-881	178	3	well	well	ADV
admet-881	178	4	-	-	PUNCT
admet-881	178	5	recognized	recognize	VERB
admet-881	178	6	to	to	PART
admet-881	178	7	have	have	VERB
admet-881	178	8	highly	highly	ADV
admet-881	178	9	variable	variable	ADJ
admet-881	178	10	absorption	absorption	NOUN
admet-881	178	11	from	from	ADP
admet-881	178	12	approved	approve	VERB
admet-881	178	13	oral	oral	ADJ
admet-881	178	14	formulations	formulation	NOUN
admet-881	178	15	because	because	SCONJ
admet-881	178	16	of	of	ADP
admet-881	178	17	poor	poor	ADJ
admet-881	178	18	dissolution	dissolution	NOUN
admet-881	179	1	[	[	X
admet-881	179	2	54,79,80	54,79,80	NUM
admet-881	179	3	]	]	X
admet-881	179	4	.	.	PUNCT
admet-881	180	1	when	when	SCONJ
admet-881	180	2	dietary	dietary	ADJ
admet-881	180	3	lipids	lipid	NOUN
admet-881	180	4	were	be	AUX
admet-881	180	5	introduced	introduce	VERB
admet-881	180	6	to	to	ADP
admet-881	180	7	the	the	DET
admet-881	180	8	perfused	perfused	ADJ
admet-881	180	9	segment	segment	NOUN
admet-881	180	10	in	in	ADP
admet-881	180	11	the	the	DET
admet-881	180	12	spip	spip	PROPN
admet-881	180	13	model	model	NOUN
admet-881	180	14	,	,	PUNCT
admet-881	180	15	they	they	PRON
admet-881	180	16	reduced	reduce	VERB
admet-881	180	17	the	the	DET
admet-881	180	18	jejunal	jejunal	ADJ
admet-881	180	19	absorption	absorption	NOUN
admet-881	180	20	of	of	ADP
admet-881	180	21	a	a	DET
admet-881	180	22	cya	cya	NOUN
admet-881	180	23	as	as	ADP
admet-881	180	24	a	a	DET
admet-881	180	25	saturated	saturate	VERB
admet-881	180	26	solution	solution	NOUN
admet-881	180	27	and	and	CCONJ
admet-881	180	28	nanosuspension	nanosuspension	NOUN
admet-881	180	29	by	by	ADP
admet-881	180	30	approximately	approximately	ADV
admet-881	180	31	50	50	NUM
admet-881	180	32	%	%	NOUN
admet-881	180	33	and	and	CCONJ
admet-881	180	34	83	83	NUM
admet-881	180	35	%	%	NOUN
admet-881	180	36	,	,	PUNCT
admet-881	180	37	respectively	respectively	ADV
admet-881	180	38	(	(	PUNCT
admet-881	180	39	table	table	NOUN
admet-881	180	40	4	4	NUM
admet-881	180	41	)	)	PUNCT
admet-881	180	42	.	.	PUNCT
admet-881	181	1	in	in	ADP
admet-881	181	2	contrast	contrast	NOUN
admet-881	181	3	,	,	PUNCT
admet-881	181	4	dietary	dietary	ADJ
admet-881	181	5	lipids	lipid	NOUN
admet-881	181	6	increased	increase	VERB
admet-881	181	7	the	the	DET
admet-881	181	8	jejunal	jejunal	ADJ
admet-881	181	9	absorption	absorption	NOUN
admet-881	181	10	of	of	ADP
admet-881	181	11	danazol	danazol	ADJ
admet-881	181	12	nanosuspensions	nanosuspension	NOUN
admet-881	181	13	more	more	ADJ
admet-881	181	14	than	than	ADP
admet-881	181	15	two	two	NUM
admet-881	181	16	-	-	PUNCT
admet-881	181	17	fold	fold	VERB
admet-881	181	18	.	.	PUNCT
admet-881	182	1	however	however	ADV
admet-881	182	2	,	,	PUNCT
admet-881	182	3	fabs	fab	NOUN
admet-881	182	4	was	be	AUX
admet-881	182	5	reduced	reduce	VERB
admet-881	182	6	by	by	ADP
admet-881	182	7	60	60	NUM
admet-881	182	8	%	%	NOUN
admet-881	182	9	when	when	SCONJ
admet-881	182	10	danazol	danazol	ADJ
admet-881	182	11	was	be	AUX
admet-881	182	12	administered	administer	VERB
admet-881	182	13	as	as	ADP
admet-881	182	14	a	a	DET
admet-881	182	15	solution	solution	NOUN
admet-881	182	16	in	in	ADP
admet-881	182	17	the	the	DET
admet-881	182	18	same	same	ADJ
admet-881	182	19	media	medium	NOUN
admet-881	182	20	(	(	PUNCT
admet-881	182	21	table	table	NOUN
admet-881	182	22	4	4	NUM
admet-881	182	23	)	)	PUNCT
admet-881	182	24	.	.	PUNCT
admet-881	183	1	table	table	NOUN
admet-881	183	2	4	4	NUM
admet-881	183	3	.	.	PUNCT
admet-881	184	1	mean	mean	VERB
admet-881	184	2	(	(	PUNCT
admet-881	184	3			PROPN
admet-881	184	4	s.d	s.d	PROPN
admet-881	184	5	)	)	PUNCT
admet-881	184	6	of	of	ADP
admet-881	184	7	effective	effective	ADJ
admet-881	184	8	jejunal	jejunal	ADJ
admet-881	184	9	permeability	permeability	NOUN
admet-881	184	10	(	(	PUNCT
admet-881	184	11	peff	peff	PROPN
admet-881	184	12	)	)	PUNCT
admet-881	184	13	and	and	CCONJ
admet-881	184	14	fraction	fraction	NOUN
admet-881	184	15	absorbed	absorb	VERB
admet-881	184	16	(	(	PUNCT
admet-881	184	17	fabs	fab	NOUN
admet-881	184	18	)	)	PUNCT
admet-881	184	19	for	for	ADP
admet-881	184	20	cyclosporine	cyclosporine	NOUN
admet-881	184	21	and	and	CCONJ
admet-881	184	22	danazol	danazol	ADJ
admet-881	184	23	during	during	ADP
admet-881	184	24	a	a	DET
admet-881	184	25	single	single	ADJ
admet-881	184	26	-	-	PUNCT
admet-881	184	27	pass	pass	NOUN
admet-881	184	28	perfusion	perfusion	NOUN
admet-881	184	29	of	of	ADP
admet-881	184	30	nanoparticles	nanoparticle	NOUN
admet-881	184	31	,	,	PUNCT
admet-881	184	32	nanoparticles	nanoparticle	NOUN
admet-881	184	33	in	in	ADP
admet-881	184	34	the	the	DET
admet-881	184	35	fed	fed	PROPN
admet-881	184	36	state	state	NOUN
admet-881	184	37	,	,	PUNCT
admet-881	184	38	and	and	CCONJ
admet-881	184	39	as	as	ADP
admet-881	184	40	a	a	DET
admet-881	184	41	saturated	saturated	ADJ
admet-881	184	42	solution	solution	NOUN
admet-881	184	43	.	.	PUNCT
admet-881	185	1	parameter	parameter	NOUN
admet-881	185	2	nanoparticles	nanoparticle	NOUN
admet-881	185	3	nanoparticles	nanoparticle	NOUN
admet-881	185	4	–	–	PUNCT
admet-881	185	5	fed	feed	VERB
admet-881	185	6	state	state	NOUN
admet-881	185	7	saturated	saturate	VERB
admet-881	185	8	solution	solution	NOUN
admet-881	185	9	cyclosporine	cyclosporine	PROPN
admet-881	185	10	peff	peff	PROPN
admet-881	185	11	(	(	PUNCT
admet-881	185	12	10	10	NUM
admet-881	185	13	-4	-4	SYM
admet-881	185	14	cm	cm	NOUN
admet-881	185	15	/	/	SYM
admet-881	185	16	s	s	NOUN
admet-881	185	17	)	)	PUNCT
admet-881	186	1	0.63	0.63	NUM
admet-881	186	2			PROPN
admet-881	186	3	0.05	0.05	NUM
admet-881	186	4	0.11	0.11	NUM
admet-881	186	5			PROPN
admet-881	186	6	0.14	0.14	NUM
admet-881	186	7	0.34	0.34	NUM
admet-881	186	8			PROPN
admet-881	186	9	0.08	0.08	NUM
admet-881	186	10	fabs	fab	NOUN
admet-881	186	11	(	(	PUNCT
admet-881	186	12	%	%	NOUN
admet-881	186	13	)	)	PUNCT
admet-881	186	14	29	29	NUM
admet-881	187	1			PROPN
admet-881	187	2	2	2	NUM
admet-881	187	3	5	5	NUM
admet-881	187	4			PROPN
admet-881	187	5	6	6	NUM
admet-881	187	6	13	13	NUM
admet-881	187	7			PROPN
admet-881	187	8	8	8	NUM
admet-881	187	9	danazol	danazol	ADJ
admet-881	187	10	peff	peff	NOUN
admet-881	187	11	(	(	PUNCT
admet-881	187	12	10	10	NUM
admet-881	187	13	-4	-4	SYM
admet-881	187	14	cm	cm	NOUN
admet-881	187	15	/	/	SYM
admet-881	187	16	s	s	PART
admet-881	187	17	)	)	PUNCT
admet-881	187	18	0.9	0.9	NUM
admet-881	188	1			PROPN
admet-881	188	2	0.4	0.4	NUM
admet-881	188	3	2.3	2.3	NUM
admet-881	188	4			PROPN
admet-881	188	5	0.4	0.4	NUM
admet-881	188	6	0.33	0.33	NUM
admet-881	188	7			PROPN
admet-881	188	8	0.09	0.09	NUM
admet-881	188	9	fabs	fab	NOUN
admet-881	188	10	(	(	PUNCT
admet-881	188	11	%	%	INTJ
admet-881	188	12	)	)	PUNCT
admet-881	188	13	36	36	NUM
admet-881	189	1			PROPN
admet-881	189	2	10	10	NUM
admet-881	189	3	58	58	NUM
admet-881	189	4			PROPN
admet-881	189	5	4	4	NUM
admet-881	189	6	17	17	NUM
admet-881	189	7			PROPN
admet-881	189	8	4	4	NUM
admet-881	189	9	this	this	DET
admet-881	189	10	difference	difference	NOUN
admet-881	189	11	for	for	ADP
admet-881	189	12	nanosuspensions	nanosuspension	NOUN
admet-881	189	13	and	and	CCONJ
admet-881	189	14	monomer	monomer	NOUN
admet-881	189	15	solutions	solution	NOUN
admet-881	189	16	of	of	ADP
admet-881	189	17	danazol	danazol	ADJ
admet-881	189	18	is	be	AUX
admet-881	189	19	most	most	ADV
admet-881	189	20	likely	likely	ADJ
admet-881	189	21	due	due	ADJ
admet-881	189	22	to	to	ADP
admet-881	189	23	increased	increase	VERB
admet-881	189	24	dissolution	dissolution	NOUN
admet-881	189	25	and/or	and/or	CCONJ
admet-881	189	26	a	a	DET
admet-881	189	27	more	more	ADV
admet-881	189	28	efficient	efficient	ADJ
admet-881	189	29	transport	transport	NOUN
admet-881	189	30	of	of	ADP
admet-881	189	31	the	the	DET
admet-881	189	32	danazol	danazol	ADJ
admet-881	189	33	nanoparticles	nanoparticle	NOUN
admet-881	189	34	(	(	PUNCT
admet-881	189	35	150	150	NUM
admet-881	189	36	nm	nm	NOUN
admet-881	189	37	)	)	PUNCT
admet-881	189	38	than	than	ADP
admet-881	189	39	the	the	DET
admet-881	189	40	cya	cya	NOUN
admet-881	189	41	(	(	PUNCT
admet-881	189	42	650	650	NUM
admet-881	189	43	nm	nm	NOUN
admet-881	189	44	)	)	PUNCT
admet-881	189	45	through	through	ADP
admet-881	189	46	the	the	DET
admet-881	189	47	particle	particle	PROPN
admet-881	189	48	abl	abl	PROPN
admet-881	189	49	.	.	PUNCT
admet-881	190	1	the	the	DET
admet-881	190	2	difference	difference	NOUN
admet-881	190	3	in	in	ADP
admet-881	190	4	the	the	DET
admet-881	190	5	effect	effect	NOUN
admet-881	190	6	of	of	ADP
admet-881	190	7	intraluminal	intraluminal	ADJ
admet-881	190	8	lipids	lipid	NOUN
admet-881	190	9	may	may	AUX
admet-881	190	10	also	also	ADV
admet-881	190	11	be	be	AUX
admet-881	190	12	explained	explain	VERB
admet-881	190	13	by	by	ADP
admet-881	190	14	different	different	ADJ
admet-881	190	15	distribution	distribution	NOUN
admet-881	190	16	of	of	ADP
admet-881	190	17	any	any	PRON
admet-881	190	18	of	of	ADP
admet-881	190	19	the	the	DET
admet-881	190	20	study	study	NOUN
admet-881	190	21	drugs	drug	NOUN
admet-881	190	22	to	to	ADP
admet-881	190	23	the	the	DET
admet-881	190	24	colloidal	colloidal	NOUN
admet-881	190	25	structures	structure	NOUN
admet-881	190	26	present	present	ADJ
admet-881	190	27	in	in	ADP
admet-881	190	28	the	the	DET
admet-881	190	29	media	medium	NOUN
admet-881	190	30	.	.	PUNCT
admet-881	191	1	these	these	DET
admet-881	191	2	structures	structure	NOUN
admet-881	191	3	affect	affect	VERB
admet-881	191	4	the	the	DET
admet-881	191	5	convective	convective	ADJ
admet-881	191	6	and	and	CCONJ
admet-881	191	7	diffusion	diffusion	NOUN
admet-881	191	8	rates	rate	NOUN
admet-881	191	9	of	of	ADP
admet-881	191	10	the	the	DET
admet-881	191	11	drugs	drug	NOUN
admet-881	191	12	differently	differently	ADV
admet-881	191	13	in	in	ADP
admet-881	191	14	the	the	DET
admet-881	191	15	perfused	perfused	ADJ
admet-881	191	16	segment	segment	NOUN
admet-881	191	17	.	.	PUNCT
admet-881	192	1	cya	cya	PROPN
admet-881	192	2	has	have	VERB
admet-881	192	3	a	a	DET
admet-881	192	4	higher	high	ADJ
admet-881	192	5	partitioning	partitioning	NOUN
admet-881	192	6	(	(	PUNCT
admet-881	192	7	2.5	2.5	NUM
admet-881	192	8	times	time	NOUN
admet-881	192	9	)	)	PUNCT
admet-881	192	10	to	to	ADP
admet-881	192	11	the	the	DET
admet-881	192	12	colloidal	colloidal	NOUN
admet-881	192	13	structures	structure	NOUN
admet-881	192	14	than	than	ADP
admet-881	192	15	danazol	danazol	ADJ
admet-881	192	16	.	.	PUNCT
admet-881	193	1	based	base	VERB
admet-881	193	2	on	on	ADP
admet-881	193	3	previous	previous	ADJ
admet-881	193	4	observations	observation	NOUN
admet-881	193	5	,	,	PUNCT
admet-881	193	6	danazol	danazol	VERB
admet-881	193	7	probably	probably	ADV
admet-881	193	8	partitions	partition	VERB
admet-881	193	9	primarily	primarily	ADV
admet-881	193	10	to	to	ADP
admet-881	193	11	the	the	DET
admet-881	193	12	mixed	mixed	ADJ
admet-881	193	13	intraluminal	intraluminal	ADJ
admet-881	193	14	micelles	micelle	NOUN
admet-881	193	15	,	,	PUNCT
admet-881	193	16	and	and	CCONJ
admet-881	193	17	to	to	ADP
admet-881	193	18	a	a	DET
admet-881	193	19	lesser	less	ADJ
admet-881	193	20	extent	extent	NOUN
admet-881	193	21	to	to	ADP
admet-881	193	22	the	the	DET
admet-881	193	23	lipid	lipid	ADJ
admet-881	193	24	vesicles	vesicle	NOUN
admet-881	193	25	[	[	X
admet-881	193	26	55	55	NUM
admet-881	193	27	]	]	PUNCT
admet-881	193	28	.	.	PUNCT
admet-881	194	1	despite	despite	SCONJ
admet-881	194	2	a	a	DET
admet-881	194	3	lower	low	ADJ
admet-881	194	4	log	log	NOUN
admet-881	194	5	p	p	NOUN
admet-881	194	6	value	value	NOUN
admet-881	194	7	,	,	PUNCT
admet-881	194	8	cya	cya	NOUN
admet-881	194	9	most	most	ADV
admet-881	194	10	likely	likely	ADJ
admet-881	194	11	partitions	partition	NOUN
admet-881	194	12	into	into	ADP
admet-881	194	13	larger	large	ADJ
admet-881	194	14	lipid	lipid	NOUN
admet-881	194	15	vesicles	vesicle	NOUN
admet-881	194	16	to	to	ADP
admet-881	194	17	a	a	DET
admet-881	194	18	greater	great	ADJ
admet-881	194	19	extent	extent	NOUN
admet-881	194	20	than	than	ADP
admet-881	194	21	danazol	danazol	ADJ
admet-881	194	22	.	.	PUNCT
admet-881	195	1	it	it	PRON
admet-881	195	2	has	have	VERB
admet-881	195	3	a	a	DET
admet-881	195	4	larger	large	ADJ
admet-881	195	5	molecular	molecular	ADJ
admet-881	195	6	size	size	NOUN
admet-881	195	7	,	,	PUNCT
admet-881	195	8	which	which	PRON
admet-881	195	9	results	result	VERB
admet-881	195	10	in	in	ADP
admet-881	195	11	a	a	DET
admet-881	195	12	reduced	reduced	ADJ
admet-881	195	13	thermodynamic	thermodynamic	ADJ
admet-881	195	14	activity	activity	NOUN
admet-881	195	15	(	(	PUNCT
admet-881	195	16	i.e.	i.e.	X
admet-881	195	17	,	,	PUNCT
admet-881	195	18	lower	low	ADJ
admet-881	195	19	free	free	ADJ
admet-881	195	20	concentration	concentration	NOUN
admet-881	195	21	available	available	ADJ
admet-881	195	22	for	for	ADP
admet-881	195	23	permeation	permeation	NOUN
admet-881	195	24	)	)	PUNCT
admet-881	195	25	.	.	PUNCT
admet-881	196	1	furthermore	furthermore	ADV
admet-881	196	2	,	,	PUNCT
admet-881	196	3	there	there	PRON
admet-881	196	4	would	would	AUX
admet-881	196	5	be	be	AUX
admet-881	196	6	an	an	DET
admet-881	196	7	overall	overall	ADJ
admet-881	196	8	slower	slow	ADJ
admet-881	196	9	diffusion	diffusion	NOUN
admet-881	196	10	and	and	CCONJ
admet-881	196	11	convection	convection	NOUN
admet-881	196	12	in	in	ADP
admet-881	196	13	the	the	DET
admet-881	196	14	intestinal	intestinal	ADJ
admet-881	196	15	lumen	luman	NOUN
admet-881	196	16	.	.	PUNCT
admet-881	197	1	another	another	DET
admet-881	197	2	plausible	plausible	ADJ
admet-881	197	3	mechanism	mechanism	NOUN
admet-881	197	4	is	be	AUX
admet-881	197	5	that	that	SCONJ
admet-881	197	6	the	the	DET
admet-881	197	7	slow	slow	ADJ
admet-881	197	8	and	and	CCONJ
admet-881	197	9	incomplete	incomplete	ADJ
admet-881	197	10	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	197	11	h.	h.	PROPN
admet-881	197	12	lennernäs	lennernäs	PROPN
admet-881	197	13	et	et	PROPN
admet-881	197	14	al	al	PROPN
admet-881	197	15	.	.	PROPN
admet-881	197	16	admet	admet	PROPN
admet-881	197	17	&	&	CCONJ
admet-881	197	18	dmpk	dmpk	PROPN
admet-881	197	19	8(4	8(4	NOUN
admet-881	197	20	)	)	PUNCT
admet-881	197	21	(	(	PUNCT
admet-881	197	22	2020	2020	NUM
admet-881	197	23	)	)	PUNCT
admet-881	197	24	375	375	NUM
admet-881	197	25	-	-	SYM
admet-881	197	26	390	390	NUM
admet-881	197	27	384	384	NUM
admet-881	197	28	partitioning	partition	VERB
admet-881	197	29	from	from	ADP
admet-881	197	30	the	the	DET
admet-881	197	31	vesicles	vesicle	NOUN
admet-881	197	32	to	to	ADP
admet-881	197	33	the	the	DET
admet-881	197	34	aqueous	aqueous	ADV
admet-881	197	35	-	-	PUNCT
admet-881	197	36	based	base	VERB
admet-881	197	37	chime	chime	NOUN
admet-881	197	38	leads	lead	VERB
admet-881	197	39	to	to	ADP
admet-881	197	40	a	a	DET
admet-881	197	41	subsequent	subsequent	ADJ
admet-881	197	42	rapid	rapid	ADJ
admet-881	197	43	intestinal	intestinal	ADJ
admet-881	197	44	absorption	absorption	NOUN
admet-881	197	45	of	of	ADP
admet-881	197	46	cya	cya	NOUN
admet-881	197	47	.	.	PUNCT
admet-881	198	1	a	a	DET
admet-881	198	2	temporarily	temporarily	ADV
admet-881	198	3	unsaturated	unsaturated	ADJ
admet-881	198	4	aqueous	aqueous	ADJ
admet-881	198	5	phase	phase	NOUN
admet-881	198	6	might	might	AUX
admet-881	198	7	form	form	VERB
admet-881	198	8	along	along	ADP
admet-881	198	9	the	the	DET
admet-881	198	10	perfused	perfused	ADJ
admet-881	198	11	jejunal	jejunal	ADJ
admet-881	198	12	segment	segment	NOUN
admet-881	198	13	and	and	CCONJ
admet-881	198	14	reduce	reduce	VERB
admet-881	198	15	thermodynamic	thermodynamic	ADJ
admet-881	198	16	activity	activity	NOUN
admet-881	198	17	.	.	PUNCT
admet-881	199	1	it	it	PRON
admet-881	199	2	is	be	AUX
admet-881	199	3	also	also	ADV
admet-881	199	4	clear	clear	ADJ
admet-881	199	5	that	that	SCONJ
admet-881	199	6	drug	drug	NOUN
admet-881	199	7	-	-	PUNCT
admet-881	199	8	solubilization	solubilization	NOUN
admet-881	199	9	is	be	AUX
admet-881	199	10	a	a	DET
admet-881	199	11	more	more	ADV
admet-881	199	12	important	important	ADJ
admet-881	199	13	factor	factor	NOUN
admet-881	199	14	in	in	ADP
admet-881	199	15	fed	fed	PROPN
admet-881	199	16	state	state	NOUN
admet-881	199	17	for	for	ADP
admet-881	199	18	cya	cya	NOUN
admet-881	199	19	than	than	ADP
admet-881	199	20	p	p	NOUN
admet-881	199	21	-	-	PUNCT
admet-881	199	22	gp	gp	NOUN
admet-881	199	23	inhibition	inhibition	NOUN
admet-881	199	24	for	for	ADP
admet-881	199	25	food	food	NOUN
admet-881	199	26	–	–	PUNCT
admet-881	199	27	drug	drug	NOUN
admet-881	199	28	interaction	interaction	NOUN
admet-881	199	29	.	.	PUNCT
admet-881	200	1	drug	drug	NOUN
admet-881	200	2	partitioning	partition	VERB
admet-881	200	3	into	into	ADP
admet-881	200	4	different	different	ADJ
admet-881	200	5	luminal	luminal	ADJ
admet-881	200	6	cs	cs	PROPN
admet-881	200	7	,	,	PUNCT
admet-881	200	8	and	and	CCONJ
admet-881	200	9	their	their	PRON
admet-881	200	10	fate	fate	NOUN
admet-881	200	11	in	in	ADP
admet-881	200	12	the	the	DET
admet-881	200	13	lumen	luman	NOUN
admet-881	200	14	and	and	CCONJ
admet-881	200	15	across	across	ADP
admet-881	200	16	the	the	DET
admet-881	200	17	abl	abl	NOUN
admet-881	200	18	,	,	PUNCT
admet-881	200	19	are	be	AUX
admet-881	200	20	important	important	ADJ
admet-881	200	21	processes	process	NOUN
admet-881	200	22	to	to	PART
admet-881	200	23	consider	consider	VERB
admet-881	200	24	in	in	ADP
admet-881	200	25	designing	design	VERB
admet-881	200	26	nano	nano	NOUN
admet-881	200	27	-	-	PUNCT
admet-881	200	28	based	base	VERB
admet-881	200	29	oral	oral	ADJ
admet-881	200	30	formulations	formulation	NOUN
admet-881	200	31	of	of	ADP
admet-881	200	32	poorly	poorly	ADV
admet-881	200	33	soluble	soluble	ADJ
admet-881	200	34	drugs	drug	NOUN
admet-881	200	35	.	.	PUNCT
admet-881	201	1	both	both	CCONJ
admet-881	201	2	the	the	DET
admet-881	201	3	peff	peff	PROPN
admet-881	201	4	and	and	CCONJ
admet-881	201	5	fabs	fab	NOUN
admet-881	201	6	were	be	AUX
admet-881	201	7	higher	high	ADJ
admet-881	201	8	for	for	ADP
admet-881	201	9	danazol	danazol	ADJ
admet-881	201	10	when	when	SCONJ
admet-881	201	11	administered	administer	VERB
admet-881	201	12	as	as	ADP
admet-881	201	13	a	a	DET
admet-881	201	14	nanosuspension	nanosuspension	NOUN
admet-881	201	15	in	in	ADP
admet-881	201	16	lipid	lipid	NOUN
admet-881	201	17	-	-	PUNCT
admet-881	201	18	containing	contain	VERB
admet-881	201	19	media	medium	NOUN
admet-881	201	20	than	than	ADP
admet-881	201	21	in	in	ADP
admet-881	201	22	the	the	DET
admet-881	201	23	control	control	NOUN
admet-881	201	24	buffer	buffer	NOUN
admet-881	201	25	.	.	PUNCT
admet-881	202	1	however	however	ADV
admet-881	202	2	,	,	PUNCT
admet-881	202	3	due	due	ADP
admet-881	202	4	to	to	ADP
admet-881	202	5	the	the	DET
admet-881	202	6	rapid	rapid	ADJ
admet-881	202	7	dissolution	dissolution	NOUN
admet-881	202	8	of	of	ADP
admet-881	202	9	the	the	DET
admet-881	202	10	nanoparticles	nanoparticle	NOUN
admet-881	202	11	,	,	PUNCT
admet-881	202	12	the	the	DET
admet-881	202	13	difference	difference	NOUN
admet-881	202	14	in	in	ADP
admet-881	202	15	absorption	absorption	NOUN
admet-881	202	16	did	do	AUX
admet-881	202	17	not	not	PART
admet-881	202	18	correspond	correspond	VERB
admet-881	202	19	to	to	PART
admet-881	202	20	previously	previously	ADV
admet-881	202	21	observed	observe	VERB
admet-881	202	22	increases	increase	NOUN
admet-881	202	23	in	in	ADP
admet-881	202	24	bioavailability	bioavailability	NOUN
admet-881	202	25	of	of	ADP
admet-881	202	26	danazol	danazol	ADJ
admet-881	202	27	administered	administer	VERB
admet-881	202	28	with	with	ADP
admet-881	202	29	food	food	NOUN
admet-881	202	30	.	.	PUNCT
admet-881	203	1	administration	administration	NOUN
admet-881	203	2	of	of	ADP
admet-881	203	3	danazol	danazol	ADJ
admet-881	203	4	in	in	ADP
admet-881	203	5	the	the	DET
admet-881	203	6	same	same	ADJ
admet-881	203	7	media	medium	NOUN
admet-881	203	8	,	,	PUNCT
admet-881	203	9	but	but	CCONJ
admet-881	203	10	as	as	ADP
admet-881	203	11	a	a	DET
admet-881	203	12	solution	solution	NOUN
admet-881	203	13	,	,	PUNCT
admet-881	203	14	decreased	decrease	VERB
admet-881	203	15	both	both	DET
admet-881	203	16	peff	peff	NOUN
admet-881	203	17	and	and	CCONJ
admet-881	203	18	fabs	fab	NOUN
admet-881	203	19	.	.	PUNCT
admet-881	204	1	this	this	PRON
admet-881	204	2	shows	show	VERB
admet-881	204	3	the	the	DET
admet-881	204	4	importance	importance	NOUN
admet-881	204	5	of	of	ADP
admet-881	204	6	the	the	DET
admet-881	204	7	rapid	rapid	ADJ
admet-881	204	8	dissolution	dissolution	NOUN
admet-881	204	9	of	of	ADP
admet-881	204	10	the	the	DET
admet-881	204	11	drug	drug	NOUN
admet-881	204	12	nanoparticles	nanoparticle	NOUN
admet-881	204	13	.	.	PUNCT
admet-881	205	1	when	when	SCONJ
admet-881	205	2	danazol	danazol	ADJ
admet-881	205	3	is	be	AUX
admet-881	205	4	administered	administer	VERB
admet-881	205	5	as	as	ADP
admet-881	205	6	a	a	DET
admet-881	205	7	solution	solution	NOUN
admet-881	205	8	,	,	PUNCT
admet-881	205	9	thermodynamic	thermodynamic	ADJ
admet-881	205	10	activity	activity	NOUN
admet-881	205	11	may	may	AUX
admet-881	205	12	decrease	decrease	VERB
admet-881	205	13	because	because	SCONJ
admet-881	205	14	absorption	absorption	NOUN
admet-881	205	15	of	of	ADP
admet-881	205	16	the	the	DET
admet-881	205	17	drug	drug	NOUN
admet-881	205	18	might	might	AUX
admet-881	205	19	create	create	VERB
admet-881	205	20	a	a	DET
admet-881	205	21	state	state	NOUN
admet-881	205	22	of	of	ADP
admet-881	205	23	undersaturation	undersaturation	NOUN
admet-881	205	24	.	.	PUNCT
admet-881	206	1	aprepitant	aprepitant	ADJ
admet-881	206	2	the	the	DET
admet-881	206	3	solubility	solubility	NOUN
admet-881	206	4	of	of	ADP
admet-881	206	5	aprepitant	aprepitant	ADJ
admet-881	206	6	in	in	ADP
admet-881	206	7	biorelevant	biorelevant	ADJ
admet-881	206	8	media	medium	NOUN
admet-881	206	9	,	,	PUNCT
admet-881	206	10	e.g.	e.g.	ADV
admet-881	206	11	,	,	PUNCT
admet-881	206	12	fasted	fast	VERB
admet-881	206	13	-	-	PUNCT
admet-881	206	14	state	state	NOUN
admet-881	206	15	simulated	simulate	VERB
admet-881	206	16	intestinal	intestinal	ADJ
admet-881	206	17	fluid	fluid	NOUN
admet-881	206	18	(	(	PUNCT
admet-881	206	19	fassif	fassif	NOUN
admet-881	206	20	)	)	PUNCT
admet-881	206	21	,	,	PUNCT
admet-881	206	22	is	be	AUX
admet-881	206	23	approximately	approximately	ADV
admet-881	206	24	60	60	NUM
admet-881	206	25	times	time	NOUN
admet-881	206	26	higher	high	ADJ
admet-881	206	27	than	than	ADP
admet-881	206	28	in	in	ADP
admet-881	206	29	buffer	buffer	NOUN
admet-881	206	30	alone	alone	ADV
admet-881	207	1	[	[	X
admet-881	207	2	60	60	NUM
admet-881	207	3	]	]	PUNCT
admet-881	207	4	.	.	PUNCT
admet-881	208	1	this	this	PRON
admet-881	208	2	indicates	indicate	VERB
admet-881	208	3	that	that	SCONJ
admet-881	208	4	aprepitant	aprepitant	ADJ
admet-881	208	5	readily	readily	ADV
admet-881	208	6	partitions	partition	NOUN
admet-881	208	7	to	to	ADP
admet-881	208	8	luminal	luminal	ADJ
admet-881	208	9	colloidal	colloidal	NOUN
admet-881	208	10	structures	structure	NOUN
admet-881	208	11	.	.	PUNCT
admet-881	209	1	the	the	DET
admet-881	209	2	influence	influence	NOUN
admet-881	209	3	of	of	ADP
admet-881	209	4	these	these	DET
admet-881	209	5	colloidal	colloidal	NOUN
admet-881	209	6	structures	structure	NOUN
admet-881	209	7	on	on	ADP
admet-881	209	8	the	the	DET
admet-881	209	9	in	in	ADP
admet-881	209	10	vivo	vivo	ADJ
admet-881	209	11	absorption	absorption	NOUN
admet-881	209	12	of	of	ADP
admet-881	209	13	aprepitant	aprepitant	ADJ
admet-881	209	14	was	be	AUX
admet-881	209	15	investigated	investigate	VERB
admet-881	209	16	in	in	ADP
admet-881	209	17	the	the	DET
admet-881	209	18	rat	rat	NOUN
admet-881	209	19	spip	spip	PROPN
admet-881	209	20	model	model	NOUN
admet-881	209	21	.	.	PUNCT
admet-881	210	1	when	when	SCONJ
admet-881	210	2	colloidal	colloidal	NOUN
admet-881	210	3	structures	structure	NOUN
admet-881	210	4	were	be	AUX
admet-881	210	5	added	add	VERB
admet-881	210	6	in	in	ADP
admet-881	210	7	the	the	DET
admet-881	210	8	perfusion	perfusion	NOUN
admet-881	210	9	medium	medium	NOUN
admet-881	210	10	,	,	PUNCT
admet-881	210	11	the	the	DET
admet-881	210	12	absorption	absorption	NOUN
admet-881	210	13	was	be	AUX
admet-881	210	14	indeed	indeed	ADV
admet-881	210	15	affected	affect	VERB
admet-881	210	16	as	as	SCONJ
admet-881	210	17	the	the	DET
admet-881	210	18	observed	observe	VERB
admet-881	210	19	small	small	ADJ
admet-881	210	20	intestinal	intestinal	ADJ
admet-881	210	21	absorption	absorption	NOUN
admet-881	210	22	rate	rate	NOUN
admet-881	210	23	increased	increase	VERB
admet-881	210	24	.	.	PUNCT
admet-881	211	1	however	however	ADV
admet-881	211	2	,	,	PUNCT
admet-881	211	3	the	the	DET
admet-881	211	4	experimentally	experimentally	ADV
admet-881	211	5	determined	determined	ADJ
admet-881	211	6	increase	increase	NOUN
admet-881	211	7	in	in	ADP
admet-881	211	8	small	small	ADJ
admet-881	211	9	intestinal	intestinal	ADJ
admet-881	211	10	absorption	absorption	NOUN
admet-881	211	11	rate	rate	NOUN
admet-881	211	12	can	can	AUX
admet-881	211	13	not	not	PART
admet-881	211	14	be	be	AUX
admet-881	211	15	explained	explain	VERB
admet-881	211	16	only	only	ADV
admet-881	211	17	by	by	ADP
admet-881	211	18	an	an	DET
admet-881	211	19	increased	increase	VERB
admet-881	211	20	luminal	luminal	ADJ
admet-881	211	21	dissolution	dissolution	NOUN
admet-881	211	22	rate	rate	NOUN
admet-881	211	23	.	.	PUNCT
admet-881	212	1	rather	rather	ADV
admet-881	212	2	,	,	PUNCT
admet-881	212	3	the	the	DET
admet-881	212	4	increased	increase	VERB
admet-881	212	5	absorption	absorption	NOUN
admet-881	212	6	rate	rate	NOUN
admet-881	212	7	may	may	AUX
admet-881	212	8	be	be	AUX
admet-881	212	9	a	a	DET
admet-881	212	10	consequence	consequence	NOUN
admet-881	212	11	of	of	ADP
admet-881	212	12	changes	change	NOUN
admet-881	212	13	to	to	ADP
admet-881	212	14	the	the	DET
admet-881	212	15	total	total	ADJ
admet-881	212	16	effective	effective	ADJ
admet-881	212	17	diffusion	diffusion	NOUN
admet-881	212	18	from	from	ADP
admet-881	212	19	the	the	DET
admet-881	212	20	bulk	bulk	NOUN
admet-881	212	21	to	to	ADP
admet-881	212	22	the	the	DET
admet-881	212	23	epithelial	epithelial	ADJ
admet-881	212	24	membrane	membrane	NOUN
admet-881	212	25	of	of	ADP
admet-881	212	26	aprepitant	aprepitant	ADJ
admet-881	212	27	,	,	PUNCT
admet-881	212	28	i.e.	i.e.	X
admet-881	212	29	,	,	PUNCT
admet-881	212	30	transport	transport	NOUN
admet-881	212	31	as	as	ADP
admet-881	212	32	free	free	ADJ
admet-881	212	33	monomers	monomer	NOUN
admet-881	212	34	and	and	CCONJ
admet-881	212	35	monomers	monomer	NOUN
admet-881	212	36	partitioned	partition	VERB
admet-881	212	37	to	to	AUX
admet-881	212	38	colloidal	colloidal	NOUN
admet-881	212	39	structures	structure	NOUN
admet-881	212	40	,	,	PUNCT
admet-881	212	41	and	and	CCONJ
admet-881	212	42	as	as	ADP
admet-881	212	43	particles	particle	NOUN
admet-881	212	44	[	[	X
admet-881	212	45	63	63	NUM
admet-881	212	46	]	]	PUNCT
admet-881	212	47	.	.	PUNCT
admet-881	213	1	total	total	ADJ
admet-881	213	2	effective	effective	ADJ
admet-881	213	3	diffusion	diffusion	NOUN
admet-881	213	4	may	may	AUX
admet-881	213	5	be	be	AUX
admet-881	213	6	an	an	DET
admet-881	213	7	appropriate	appropriate	ADJ
admet-881	213	8	parameter	parameter	NOUN
admet-881	213	9	to	to	PART
admet-881	213	10	describe	describe	VERB
admet-881	213	11	these	these	DET
admet-881	213	12	experimental	experimental	ADJ
admet-881	213	13	observations	observation	NOUN
admet-881	213	14	and	and	CCONJ
admet-881	213	15	to	to	PART
admet-881	213	16	translate	translate	VERB
admet-881	213	17	the	the	DET
admet-881	213	18	spip	spip	PROPN
admet-881	213	19	data	datum	NOUN
admet-881	213	20	on	on	ADP
admet-881	213	21	nanoparticle	nanoparticle	NOUN
admet-881	213	22	formulations	formulation	NOUN
admet-881	213	23	to	to	PART
admet-881	213	24	in	in	ADP
admet-881	213	25	vivo	vivo	ADJ
admet-881	213	26	performance	performance	NOUN
admet-881	213	27	.	.	PUNCT
admet-881	214	1	these	these	DET
admet-881	214	2	specific	specific	ADJ
admet-881	214	3	data	datum	NOUN
admet-881	214	4	have	have	AUX
admet-881	214	5	been	be	AUX
admet-881	214	6	used	use	VERB
admet-881	214	7	to	to	PART
admet-881	214	8	evaluate	evaluate	VERB
admet-881	214	9	a	a	DET
admet-881	214	10	mathematical	mathematical	ADJ
admet-881	214	11	model	model	NOUN
admet-881	214	12	simulating	simulate	VERB
admet-881	214	13	the	the	DET
admet-881	214	14	absorption	absorption	NOUN
admet-881	214	15	-	-	PUNCT
admet-881	214	16	promoting	promote	VERB
admet-881	214	17	effects	effect	NOUN
admet-881	214	18	of	of	ADP
admet-881	214	19	nanoparticle	nanoparticle	NOUN
admet-881	214	20	formulations	formulation	NOUN
admet-881	214	21	.	.	PUNCT
admet-881	215	1	this	this	DET
admet-881	215	2	model	model	NOUN
admet-881	215	3	included	include	VERB
admet-881	215	4	interlinked	interlink	VERB
admet-881	215	5	descriptions	description	NOUN
admet-881	215	6	of	of	ADP
admet-881	215	7	hydrodynamics	hydrodynamic	NOUN
admet-881	215	8	,	,	PUNCT
admet-881	215	9	particle	particle	NOUN
admet-881	215	10	dissolution	dissolution	NOUN
admet-881	215	11	,	,	PUNCT
admet-881	215	12	and	and	CCONJ
admet-881	215	13	particle	particle	NOUN
admet-881	215	14	diffusion	diffusion	NOUN
admet-881	215	15	for	for	ADP
admet-881	215	16	both	both	CCONJ
admet-881	215	17	the	the	DET
admet-881	215	18	api	api	NOUN
admet-881	215	19	and	and	CCONJ
admet-881	215	20	luminal	luminal	ADJ
admet-881	215	21	colloidal	colloidal	NOUN
admet-881	215	22	structures	structure	NOUN
admet-881	215	23	.	.	PUNCT
admet-881	216	1	this	this	DET
admet-881	216	2	mathematical	mathematical	ADJ
admet-881	216	3	,	,	PUNCT
admet-881	216	4	mechanistic	mechanistic	ADJ
admet-881	216	5	model	model	NOUN
admet-881	216	6	adequately	adequately	ADV
admet-881	216	7	describes	describe	VERB
admet-881	216	8	the	the	DET
admet-881	216	9	above	above	ADJ
admet-881	216	10	discussed	discuss	VERB
admet-881	216	11	in	in	ADP
admet-881	216	12	vivo	vivo	ADJ
admet-881	216	13	absorption	absorption	NOUN
admet-881	216	14	data	datum	NOUN
admet-881	216	15	of	of	ADP
admet-881	216	16	nano	nano	NOUN
admet-881	216	17	-	-	PUNCT
admet-881	216	18	formulated	formulate	VERB
admet-881	216	19	aprepitant	aprepitant	ADJ
admet-881	216	20	.	.	PUNCT
admet-881	217	1	it	it	PRON
admet-881	217	2	also	also	ADV
admet-881	217	3	supports	support	VERB
admet-881	217	4	the	the	DET
admet-881	217	5	proposed	propose	VERB
admet-881	217	6	mechanism	mechanism	NOUN
admet-881	217	7	by	by	ADP
admet-881	217	8	which	which	PRON
admet-881	217	9	contributing	contribute	VERB
admet-881	217	10	effects	effect	NOUN
admet-881	217	11	of	of	ADP
admet-881	217	12	the	the	DET
admet-881	217	13	diffusion	diffusion	NOUN
admet-881	217	14	across	across	ADP
admet-881	217	15	the	the	DET
admet-881	217	16	mucus	mucus	NOUN
admet-881	217	17	layer	layer	NOUN
admet-881	217	18	of	of	ADP
admet-881	217	19	both	both	DET
admet-881	217	20	aprepitant	aprepitant	ADJ
admet-881	217	21	nanoparticles	nanoparticle	NOUN
admet-881	217	22	and	and	CCONJ
admet-881	217	23	colloidal	colloidal	NOUN
admet-881	217	24	structures	structure	NOUN
admet-881	217	25	into	into	ADP
admet-881	217	26	which	which	PRON
admet-881	217	27	the	the	DET
admet-881	217	28	drug	drug	NOUN
admet-881	217	29	had	have	AUX
admet-881	217	30	partitioned	partition	VERB
admet-881	217	31	[	[	X
admet-881	217	32	81	81	NUM
admet-881	217	33	]	]	PUNCT
admet-881	217	34	.	.	PUNCT
admet-881	218	1	this	this	PRON
admet-881	218	2	exemplifies	exemplify	VERB
admet-881	218	3	a	a	DET
admet-881	218	4	model	model	NOUN
admet-881	218	5	in	in	ADP
admet-881	218	6	which	which	DET
admet-881	218	7	representation	representation	NOUN
admet-881	218	8	of	of	ADP
admet-881	218	9	physiology	physiology	NOUN
admet-881	218	10	and	and	CCONJ
admet-881	218	11	description	description	NOUN
admet-881	218	12	of	of	ADP
admet-881	218	13	mechanistic	mechanistic	ADJ
admet-881	218	14	formulationphysiology	formulationphysiology	NOUN
admet-881	218	15	relationships	relationship	NOUN
admet-881	218	16	was	be	AUX
admet-881	218	17	pivotal	pivotal	ADJ
admet-881	218	18	to	to	PART
admet-881	218	19	establish	establish	VERB
admet-881	218	20	the	the	DET
admet-881	218	21	role	role	NOUN
admet-881	218	22	of	of	ADP
admet-881	218	23	formulation	formulation	NOUN
admet-881	218	24	for	for	ADP
admet-881	218	25	effective	effective	ADJ
admet-881	218	26	drug	drug	NOUN
admet-881	218	27	absorption	absorption	NOUN
admet-881	218	28	.	.	PUNCT
admet-881	219	1	the	the	DET
admet-881	219	2	need	need	NOUN
admet-881	219	3	of	of	ADP
admet-881	219	4	such	such	ADJ
admet-881	219	5	physiologically	physiologically	ADV
admet-881	219	6	based	base	VERB
admet-881	219	7	biopharmaceutics	biopharmaceutics	NOUN
admet-881	219	8	models	model	NOUN
admet-881	219	9	(	(	PUNCT
admet-881	219	10	pbbm	pbbm	NUM
admet-881	219	11	)	)	PUNCT
admet-881	219	12	for	for	ADP
admet-881	219	13	predictions	prediction	NOUN
admet-881	219	14	and	and	CCONJ
admet-881	219	15	assessments	assessment	NOUN
admet-881	219	16	of	of	ADP
admet-881	219	17	formulations	formulation	NOUN
admet-881	219	18	in	in	ADP
admet-881	219	19	vivo	vivo	ADJ
admet-881	219	20	performance	performance	NOUN
admet-881	219	21	has	have	AUX
admet-881	219	22	recently	recently	ADV
admet-881	219	23	been	be	AUX
admet-881	219	24	highlighted	highlight	VERB
admet-881	219	25	with	with	ADP
admet-881	219	26	an	an	DET
admet-881	219	27	increased	increase	VERB
admet-881	219	28	scientific	scientific	ADJ
admet-881	219	29	activity	activity	NOUN
admet-881	219	30	in	in	ADP
admet-881	219	31	the	the	DET
admet-881	219	32	area	area	NOUN
admet-881	220	1	[	[	X
admet-881	220	2	1,82	1,82	PROPN
admet-881	220	3	]	]	PUNCT
admet-881	220	4	.	.	PUNCT
admet-881	220	5	fenofibrate	fenofibrate	PROPN
admet-881	220	6	and	and	CCONJ
admet-881	220	7	other	other	ADJ
admet-881	220	8	drugs	drug	NOUN
admet-881	220	9	in	in	ADP
admet-881	220	10	contrast	contrast	NOUN
admet-881	220	11	to	to	ADP
admet-881	220	12	these	these	DET
admet-881	220	13	absorption	absorption	NOUN
admet-881	220	14	-	-	PUNCT
admet-881	220	15	promoting	promote	VERB
admet-881	220	16	results	result	NOUN
admet-881	220	17	for	for	ADP
admet-881	220	18	nanoparticles	nanoparticle	NOUN
admet-881	220	19	aprepitant	aprepitant	ADJ
admet-881	220	20	and	and	CCONJ
admet-881	220	21	danazol	danazol	ADJ
admet-881	220	22	in	in	ADP
admet-881	220	23	both	both	PRON
admet-881	220	24	fasted	fast	VERB
admet-881	220	25	and	and	CCONJ
admet-881	220	26	fed	feed	VERB
admet-881	220	27	conditions	condition	NOUN
admet-881	220	28	in	in	ADP
admet-881	220	29	the	the	DET
admet-881	220	30	spip	spip	PROPN
admet-881	220	31	model	model	NOUN
admet-881	220	32	,	,	PUNCT
admet-881	220	33	only	only	ADV
admet-881	220	34	the	the	DET
admet-881	220	35	fed	fed	PROPN
admet-881	220	36	state	state	NOUN
admet-881	220	37	reduces	reduce	VERB
admet-881	220	38	the	the	DET
admet-881	220	39	intestinal	intestinal	ADJ
admet-881	220	40	absorption	absorption	NOUN
admet-881	220	41	of	of	ADP
admet-881	220	42	nanosized	nanosized	ADJ
admet-881	220	43	drugs	drug	NOUN
admet-881	220	44	such	such	ADJ
admet-881	220	45	as	as	ADP
admet-881	220	46	fenofibrate	fenofibrate	NOUN
admet-881	220	47	,	,	PUNCT
admet-881	220	48	csa	csa	PROPN
admet-881	220	49	,	,	PUNCT
admet-881	220	50	pafenolol	pafenolol	NOUN
admet-881	221	1	[	[	X
admet-881	221	2	37,55,83,84	37,55,83,84	NUM
admet-881	221	3	]	]	PUNCT
admet-881	221	4	.	.	PUNCT
admet-881	222	1	in	in	ADP
admet-881	222	2	a	a	DET
admet-881	222	3	regional	regional	ADJ
admet-881	222	4	absorption	absorption	NOUN
admet-881	222	5	study	study	NOUN
admet-881	222	6	in	in	ADP
admet-881	222	7	humans	human	NOUN
admet-881	222	8	with	with	ADP
admet-881	222	9	a	a	DET
admet-881	222	10	site	site	NOUN
admet-881	222	11	-	-	PUNCT
admet-881	222	12	specific	specific	ADJ
admet-881	222	13	delivery	delivery	NOUN
admet-881	222	14	system	system	NOUN
admet-881	222	15	(	(	PUNCT
admet-881	222	16	enterion	enterion	NOUN
admet-881	222	17	capsule	capsule	NOUN
admet-881	222	18	)	)	PUNCT
admet-881	222	19	,	,	PUNCT
admet-881	222	20	fenofibrate	fenofibrate	NOUN
admet-881	222	21	were	be	AUX
admet-881	222	22	given	give	VERB
admet-881	222	23	as	as	ADP
admet-881	222	24	single	single	ADJ
admet-881	222	25	,	,	PUNCT
admet-881	222	26	equimolar	equimolar	ADJ
admet-881	222	27	doses	dose	NOUN
admet-881	222	28	into	into	ADP
admet-881	222	29	the	the	DET
admet-881	222	30	stomach	stomach	NOUN
admet-881	222	31	,	,	PUNCT
admet-881	222	32	proximal	proximal	ADJ
admet-881	222	33	small	small	ADJ
admet-881	222	34	bowel	bowel	NOUN
admet-881	222	35	,	,	PUNCT
admet-881	222	36	distal	distal	ADJ
admet-881	222	37	small	small	ADJ
admet-881	222	38	bowel	bowel	NOUN
admet-881	222	39	,	,	PUNCT
admet-881	222	40	and	and	CCONJ
admet-881	222	41	colon	colon	NOUN
admet-881	222	42	.	.	PUNCT
admet-881	223	1	the	the	DET
admet-881	223	2	bioavailability	bioavailability	NOUN
admet-881	223	3	(	(	PUNCT
admet-881	223	4	related	relate	VERB
admet-881	223	5	to	to	ADP
admet-881	223	6	an	an	DET
admet-881	223	7	intravenous	intravenous	ADJ
admet-881	223	8	dose	dose	NOUN
admet-881	223	9	of	of	ADP
admet-881	223	10	fenofibric	fenofibric	NOUN
admet-881	223	11	acid	acid	NOUN
admet-881	223	12	)	)	PUNCT
admet-881	223	13	in	in	ADP
admet-881	223	14	the	the	DET
admet-881	223	15	stomach	stomach	NOUN
admet-881	223	16	,	,	PUNCT
admet-881	223	17	proximal	proximal	ADJ
admet-881	223	18	small	small	ADJ
admet-881	223	19	bowel	bowel	NOUN
admet-881	223	20	,	,	PUNCT
admet-881	223	21	distal	distal	ADJ
admet-881	223	22	small	small	ADJ
admet-881	223	23	bowel	bowel	NOUN
admet-881	223	24	,	,	PUNCT
admet-881	223	25	and	and	CCONJ
admet-881	223	26	colon	colon	NOUN
admet-881	223	27	was	be	AUX
admet-881	223	28	69	69	NUM
admet-881	223	29	%	%	NOUN
admet-881	223	30	,	,	PUNCT
admet-881	223	31	73	73	NUM
admet-881	223	32	%	%	NOUN
admet-881	223	33	,	,	PUNCT
admet-881	223	34	admet	admet	PROPN
admet-881	223	35	&	&	CCONJ
admet-881	223	36	dmpk	dmpk	PROPN
admet-881	223	37	8(4	8(4	NOUN
admet-881	223	38	)	)	PUNCT
admet-881	223	39	(	(	PUNCT
admet-881	223	40	2020	2020	NUM
admet-881	223	41	)	)	PUNCT
admet-881	223	42	375	375	NUM
admet-881	223	43	-	-	SYM
admet-881	223	44	390	390	NUM
admet-881	223	45	intestinal	intestinal	ADJ
admet-881	223	46	absorption	absorption	NOUN
admet-881	223	47	of	of	ADP
admet-881	223	48	bcs	bcs	NOUN
admet-881	223	49	class	class	NOUN
admet-881	223	50	ii	ii	PROPN
admet-881	223	51	drugs	drug	NOUN
admet-881	223	52	nanoparticles	nanoparticle	NOUN
admet-881	223	53	doi	doi	NOUN
admet-881	223	54	:	:	PUNCT
admet-881	223	55	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	223	56	385	385	NUM
admet-881	223	57	66	66	NUM
admet-881	223	58	%	%	NOUN
admet-881	223	59	,	,	PUNCT
admet-881	223	60	and	and	CCONJ
admet-881	223	61	22	22	NUM
admet-881	223	62	%	%	NOUN
admet-881	223	63	,	,	PUNCT
admet-881	223	64	respectively	respectively	ADV
admet-881	223	65	[	[	X
admet-881	223	66	85	85	NUM
admet-881	223	67	]	]	PUNCT
admet-881	223	68	.	.	PUNCT
admet-881	224	1	this	this	PRON
admet-881	224	2	clearly	clearly	ADV
admet-881	224	3	shows	show	VERB
admet-881	224	4	that	that	DET
admet-881	224	5	fenofibrate	fenofibrate	NOUN
admet-881	224	6	is	be	AUX
admet-881	224	7	absorbed	absorb	VERB
admet-881	224	8	from	from	ADP
admet-881	224	9	the	the	DET
admet-881	224	10	small	small	ADJ
admet-881	224	11	intestine	intestine	NOUN
admet-881	224	12	.	.	PUNCT
admet-881	225	1	however	however	ADV
admet-881	225	2	,	,	PUNCT
admet-881	225	3	the	the	DET
admet-881	225	4	solubility	solubility	NOUN
admet-881	225	5	and	and	CCONJ
admet-881	225	6	dissolution	dissolution	NOUN
admet-881	225	7	conditions	condition	NOUN
admet-881	225	8	in	in	ADP
admet-881	225	9	the	the	DET
admet-881	225	10	colon	colon	NOUN
admet-881	225	11	—	—	PUNCT
admet-881	225	12	less	less	ADV
admet-881	225	13	fluid	fluid	ADJ
admet-881	225	14	and	and	CCONJ
admet-881	225	15	limited	limited	ADJ
admet-881	225	16	amounts	amount	NOUN
admet-881	225	17	of	of	ADP
admet-881	225	18	bile	bile	NOUN
admet-881	225	19	acids	acid	NOUN
admet-881	225	20	and	and	CCONJ
admet-881	225	21	colloidal	colloidal	NOUN
admet-881	225	22	structures	structure	NOUN
admet-881	225	23	—	—	PUNCT
admet-881	225	24	prevent	prevent	VERB
admet-881	225	25	efficient	efficient	ADJ
admet-881	225	26	fenofibrate	fenofibrate	NOUN
admet-881	225	27	absorption	absorption	NOUN
admet-881	225	28	from	from	ADP
admet-881	225	29	this	this	DET
admet-881	225	30	region	region	NOUN
admet-881	225	31	.	.	PUNCT
admet-881	226	1	an	an	DET
admet-881	226	2	in	in	ADP
admet-881	226	3	vivo	vivo	NOUN
admet-881	226	4	study	study	NOUN
admet-881	226	5	in	in	ADP
admet-881	226	6	rats	rat	NOUN
admet-881	226	7	compared	compare	VERB
admet-881	226	8	in	in	ADP
admet-881	226	9	vitro	vitro	X
admet-881	226	10	dissolution	dissolution	NOUN
admet-881	226	11	,	,	PUNCT
admet-881	226	12	solubility	solubility	NOUN
admet-881	226	13	and	and	CCONJ
admet-881	226	14	bioavailability	bioavailability	NOUN
admet-881	226	15	of	of	ADP
admet-881	226	16	three	three	NUM
admet-881	226	17	different	different	ADJ
admet-881	226	18	oral	oral	ADJ
admet-881	226	19	nanosystems	nanosystem	NOUN
admet-881	226	20	with	with	ADP
admet-881	226	21	fenofibrate	fenofibrate	NOUN
admet-881	226	22	powder	powder	NOUN
admet-881	226	23	.	.	PUNCT
admet-881	227	1	the	the	DET
admet-881	227	2	three	three	NUM
admet-881	227	3	systems	system	NOUN
admet-881	227	4	included	include	VERB
admet-881	227	5	pvp	pvp	NOUN
admet-881	227	6	nanospheres	nanosphere	NOUN
admet-881	227	7	,	,	PUNCT
admet-881	227	8	hp	hp	PROPN
admet-881	227	9	-	-	PUNCT
admet-881	227	10	β	β	NOUN
admet-881	227	11	-	-	ADJ
admet-881	227	12	cd	cd	ADJ
admet-881	227	13	nanocapsules	nanocapsule	NOUN
admet-881	227	14	,	,	PUNCT
admet-881	227	15	and	and	CCONJ
admet-881	227	16	gelatin	gelatin	NOUN
admet-881	227	17	nanocapsules	nanocapsule	NOUN
admet-881	227	18	[	[	X
admet-881	227	19	86	86	NUM
admet-881	227	20	]	]	PUNCT
admet-881	227	21	.	.	PUNCT
admet-881	228	1	the	the	DET
admet-881	228	2	most	most	ADV
admet-881	228	3	improved	improved	ADJ
admet-881	228	4	apparent	apparent	ADJ
admet-881	228	5	solubility	solubility	NOUN
admet-881	228	6	and	and	CCONJ
admet-881	228	7	oral	oral	ADJ
admet-881	228	8	bioavailability	bioavailability	NOUN
admet-881	228	9	in	in	ADP
admet-881	228	10	fasted	fasted	ADJ
admet-881	228	11	rats	rat	NOUN
admet-881	228	12	was	be	AUX
admet-881	228	13	with	with	ADP
admet-881	228	14	fenofibrate	fenofibrate	NOUN
admet-881	228	15	nanoencapsualted	nanoencapsualte	VERB
admet-881	228	16	with	with	ADP
admet-881	228	17	gelatin	gelatin	NOUN
admet-881	228	18	at	at	ADP
admet-881	228	19	a	a	DET
admet-881	228	20	ratio	ratio	NOUN
admet-881	228	21	of	of	ADP
admet-881	228	22	1:8	1:8	NUM
admet-881	228	23	(	(	PUNCT
admet-881	228	24	w	w	PROPN
admet-881	228	25	/	/	SYM
admet-881	228	26	w	w	NOUN
admet-881	228	27	)	)	PUNCT
admet-881	228	28	.	.	PUNCT
admet-881	229	1	the	the	DET
admet-881	229	2	authors	author	NOUN
admet-881	229	3	of	of	ADP
admet-881	229	4	the	the	DET
admet-881	229	5	study	study	NOUN
admet-881	229	6	proposed	propose	VERB
admet-881	229	7	that	that	SCONJ
admet-881	229	8	the	the	DET
admet-881	229	9	improved	improve	VERB
admet-881	229	10	dissolution	dissolution	NOUN
admet-881	229	11	rate	rate	NOUN
admet-881	229	12	and	and	CCONJ
admet-881	229	13	subsequent	subsequent	ADJ
admet-881	229	14	intestinal	intestinal	ADJ
admet-881	229	15	absorption	absorption	NOUN
admet-881	229	16	was	be	AUX
admet-881	229	17	due	due	ADJ
admet-881	229	18	to	to	ADP
admet-881	229	19	:	:	PUNCT
admet-881	229	20	(	(	PUNCT
admet-881	229	21	i	i	NOUN
admet-881	229	22	)	)	PUNCT
admet-881	229	23	a	a	DET
admet-881	229	24	higher	high	ADJ
admet-881	229	25	solubility	solubility	NOUN
admet-881	229	26	of	of	ADP
admet-881	229	27	fenofibrate	fenofibrate	NOUN
admet-881	229	28	as	as	SCONJ
admet-881	229	29	it	it	PRON
admet-881	229	30	converted	convert	VERB
admet-881	229	31	into	into	ADP
admet-881	229	32	the	the	DET
admet-881	229	33	amorphous	amorphous	ADJ
admet-881	229	34	form	form	NOUN
admet-881	229	35	or	or	CCONJ
admet-881	229	36	nanocrystalline	nanocrystalline	ADJ
admet-881	229	37	state	state	NOUN
admet-881	229	38	;	;	PUNCT
admet-881	229	39	(	(	PUNCT
admet-881	229	40	ii	ii	NOUN
admet-881	229	41	)	)	PUNCT
admet-881	229	42	a	a	DET
admet-881	229	43	large	large	ADJ
admet-881	229	44	surface	surface	NOUN
admet-881	229	45	area	area	NOUN
admet-881	229	46	for	for	ADP
admet-881	229	47	dissolution	dissolution	NOUN
admet-881	229	48	of	of	ADP
admet-881	229	49	drug	drug	NOUN
admet-881	229	50	;	;	PUNCT
admet-881	229	51	(	(	PUNCT
admet-881	229	52	iii	iii	NOUN
admet-881	229	53	)	)	PUNCT
admet-881	229	54	improved	improve	VERB
admet-881	229	55	wetting	wetting	NOUN
admet-881	229	56	of	of	ADP
admet-881	229	57	fenofibrate	fenofibrate	NOUN
admet-881	229	58	by	by	ADP
admet-881	229	59	the	the	DET
admet-881	229	60	polymeric	polymeric	ADJ
admet-881	229	61	matrix	matrix	NOUN
admet-881	229	62	in	in	ADP
admet-881	229	63	the	the	DET
admet-881	229	64	formulation	formulation	NOUN
admet-881	229	65	;	;	PUNCT
admet-881	229	66	and	and	CCONJ
admet-881	229	67	(	(	PUNCT
admet-881	229	68	iv	iv	X
admet-881	229	69	)	)	PUNCT
admet-881	229	70	reduction	reduction	NOUN
admet-881	229	71	in	in	ADP
admet-881	229	72	the	the	DET
admet-881	229	73	crystalline	crystalline	NOUN
admet-881	229	74	intensity	intensity	NOUN
admet-881	229	75	.	.	PUNCT
admet-881	230	1	a	a	DET
admet-881	230	2	method	method	NOUN
admet-881	230	3	to	to	PART
admet-881	230	4	investigate	investigate	VERB
admet-881	230	5	in	in	ADP
admet-881	230	6	vivo	vivo	NOUN
admet-881	230	7	-	-	PUNCT
admet-881	230	8	relevant	relevant	ADJ
admet-881	230	9	mechanisms	mechanism	NOUN
admet-881	230	10	of	of	ADP
admet-881	230	11	drug	drug	NOUN
admet-881	230	12	absorption	absorption	NOUN
admet-881	230	13	in	in	ADP
admet-881	230	14	humans	human	NOUN
admet-881	230	15	is	be	AUX
admet-881	230	16	by	by	ADP
admet-881	230	17	gi	gi	NOUN
admet-881	230	18	fluid	fluid	ADJ
admet-881	230	19	sampling	sampling	NOUN
admet-881	230	20	[	[	X
admet-881	230	21	52,87	52,87	NUM
admet-881	230	22	]	]	PUNCT
admet-881	230	23	.	.	PUNCT
admet-881	231	1	gi	gi	NOUN
admet-881	231	2	intubation	intubation	NOUN
admet-881	231	3	can	can	AUX
admet-881	231	4	explore	explore	VERB
admet-881	231	5	directly	directly	ADV
admet-881	231	6	the	the	DET
admet-881	231	7	dynamic	dynamic	ADJ
admet-881	231	8	interplay	interplay	NOUN
admet-881	231	9	of	of	ADP
admet-881	231	10	drug	drug	NOUN
admet-881	231	11	release	release	NOUN
admet-881	231	12	,	,	PUNCT
admet-881	231	13	dissolution	dissolution	NOUN
admet-881	231	14	,	,	PUNCT
admet-881	231	15	precipitation	precipitation	NOUN
admet-881	231	16	,	,	PUNCT
admet-881	231	17	and	and	CCONJ
admet-881	231	18	absorption	absorption	NOUN
admet-881	231	19	of	of	ADP
admet-881	231	20	the	the	DET
admet-881	231	21	drug	drug	NOUN
admet-881	231	22	from	from	ADP
admet-881	231	23	a	a	DET
admet-881	231	24	dosage	dosage	NOUN
admet-881	231	25	form	form	NOUN
admet-881	231	26	.	.	PUNCT
admet-881	232	1	the	the	DET
admet-881	232	2	dissolved	dissolve	VERB
admet-881	232	3	drug	drug	NOUN
admet-881	232	4	and	and	CCONJ
admet-881	232	5	solid	solid	ADJ
admet-881	232	6	-	-	PUNCT
admet-881	232	7	state	state	NOUN
admet-881	232	8	concentration	concentration	NOUN
admet-881	232	9	–	–	PUNCT
admet-881	232	10	time	time	NOUN
admet-881	232	11	profiles	profile	NOUN
admet-881	232	12	from	from	ADP
admet-881	232	13	different	different	ADJ
admet-881	232	14	segments	segment	NOUN
admet-881	232	15	in	in	ADP
admet-881	232	16	the	the	DET
admet-881	232	17	gi	gi	NOUN
admet-881	232	18	tract	tract	NOUN
admet-881	232	19	can	can	AUX
admet-881	232	20	be	be	AUX
admet-881	232	21	obtained	obtain	VERB
admet-881	232	22	.	.	PUNCT
admet-881	233	1	in	in	ADP
admet-881	233	2	addition	addition	NOUN
admet-881	233	3	,	,	PUNCT
admet-881	233	4	direct	direct	ADJ
admet-881	233	5	infusion	infusion	NOUN
admet-881	233	6	of	of	ADP
admet-881	233	7	a	a	DET
admet-881	233	8	suspension	suspension	NOUN
admet-881	233	9	into	into	ADP
admet-881	233	10	the	the	DET
admet-881	233	11	duodenum	duodenum	NOUN
admet-881	233	12	allows	allow	VERB
admet-881	233	13	patient	patient	ADJ
admet-881	233	14	control	control	NOUN
admet-881	233	15	of	of	ADP
admet-881	233	16	the	the	DET
admet-881	233	17	therapeutic	therapeutic	ADJ
admet-881	233	18	system	system	NOUN
admet-881	233	19	[	[	X
admet-881	233	20	88,89	88,89	NOUN
admet-881	233	21	]	]	X
admet-881	233	22	.	.	PUNCT
admet-881	234	1	one	one	NUM
admet-881	234	2	study	study	NOUN
admet-881	234	3	compared	compare	VERB
admet-881	234	4	nanoand	nanoand	PROPN
admet-881	234	5	microsuspensions	microsuspension	NOUN
admet-881	234	6	of	of	ADP
admet-881	234	7	fenofibrate	fenofibrate	NOUN
admet-881	234	8	administered	administer	VERB
admet-881	234	9	orally	orally	ADV
admet-881	234	10	in	in	ADP
admet-881	234	11	fed	fed	PROPN
admet-881	234	12	state	state	NOUN
admet-881	234	13	in	in	ADP
admet-881	234	14	humans	human	NOUN
admet-881	234	15	.	.	PUNCT
admet-881	235	1	the	the	DET
admet-881	235	2	nanosuspensions	nanosuspension	NOUN
admet-881	235	3	gave	give	VERB
admet-881	235	4	higher	high	ADJ
admet-881	235	5	local	local	ADJ
admet-881	235	6	concentrations	concentration	NOUN
admet-881	235	7	than	than	ADP
admet-881	235	8	the	the	DET
admet-881	235	9	microsuspensions	microsuspension	NOUN
admet-881	235	10	in	in	ADP
admet-881	235	11	the	the	DET
admet-881	235	12	proximal	proximal	ADJ
admet-881	235	13	small	small	ADJ
admet-881	235	14	intestinal	intestinal	ADJ
admet-881	235	15	lumen	luman	NOUN
admet-881	235	16	and	and	CCONJ
admet-881	235	17	resulted	result	VERB
admet-881	235	18	in	in	ADP
admet-881	235	19	higher	high	ADJ
admet-881	235	20	absorption	absorption	NOUN
admet-881	235	21	and	and	CCONJ
admet-881	235	22	plasma	plasma	NOUN
admet-881	235	23	exposure	exposure	NOUN
admet-881	235	24	–	–	PUNCT
admet-881	235	25	time	time	NOUN
admet-881	235	26	profile	profile	NOUN
admet-881	235	27	of	of	ADP
admet-881	235	28	the	the	DET
admet-881	235	29	drug	drug	NOUN
admet-881	235	30	[	[	X
admet-881	235	31	37	37	NUM
admet-881	235	32	]	]	PUNCT
admet-881	235	33	.	.	PUNCT
admet-881	236	1	in	in	ADP
admet-881	236	2	fed	fed	PROPN
admet-881	236	3	conditions	condition	NOUN
admet-881	236	4	,	,	PUNCT
admet-881	236	5	the	the	DET
admet-881	236	6	duodenal	duodenal	ADJ
admet-881	236	7	concentrations	concentration	NOUN
admet-881	236	8	of	of	ADP
admet-881	236	9	fenofibrate	fenofibrate	NOUN
admet-881	236	10	were	be	AUX
admet-881	236	11	higher	high	ADJ
admet-881	236	12	for	for	ADP
admet-881	236	13	both	both	DET
admet-881	236	14	oral	oral	ADJ
admet-881	236	15	formulations	formulation	NOUN
admet-881	236	16	,	,	PUNCT
admet-881	236	17	but	but	CCONJ
admet-881	236	18	there	there	PRON
admet-881	236	19	was	be	VERB
admet-881	236	20	no	no	DET
admet-881	236	21	increase	increase	NOUN
admet-881	236	22	in	in	ADP
admet-881	236	23	plasma	plasma	NOUN
admet-881	236	24	exposure	exposure	NOUN
admet-881	236	25	of	of	ADP
admet-881	236	26	fenofibric	fenofibric	ADJ
admet-881	236	27	acid	acid	NOUN
admet-881	236	28	.	.	PUNCT
admet-881	237	1	micellar	micellar	ADJ
admet-881	237	2	encapsulation	encapsulation	NOUN
admet-881	237	3	of	of	ADP
admet-881	237	4	the	the	DET
admet-881	237	5	fenofibrate	fenofibrate	NOUN
admet-881	237	6	in	in	ADP
admet-881	237	7	the	the	DET
admet-881	237	8	lumen	luman	NOUN
admet-881	237	9	may	may	AUX
admet-881	237	10	have	have	AUX
admet-881	237	11	limited	limit	VERB
admet-881	237	12	potential	potential	NOUN
admet-881	237	13	to	to	PART
admet-881	237	14	permeate	permeate	VERB
admet-881	237	15	from	from	ADP
admet-881	237	16	colloidal	colloidal	NOUN
admet-881	237	17	structures	structure	NOUN
admet-881	237	18	in	in	ADP
admet-881	237	19	fed	fed	PROPN
admet-881	237	20	-	-	PUNCT
admet-881	237	21	state	state	NOUN
admet-881	237	22	intestinal	intestinal	ADJ
admet-881	237	23	fluids	fluid	NOUN
admet-881	237	24	.	.	PUNCT
admet-881	238	1	absorption	absorption	NOUN
admet-881	238	2	can	can	AUX
admet-881	238	3	also	also	ADV
admet-881	238	4	decrease	decrease	VERB
admet-881	238	5	in	in	ADP
admet-881	238	6	the	the	DET
admet-881	238	7	presence	presence	NOUN
admet-881	238	8	of	of	ADP
admet-881	238	9	micelle	micelle	NOUN
admet-881	238	10	-	-	PUNCT
admet-881	238	11	forming	form	VERB
admet-881	238	12	lipids	lipid	NOUN
admet-881	238	13	due	due	ADP
admet-881	238	14	to	to	ADP
admet-881	238	15	lower	low	ADJ
admet-881	238	16	thermodynamic	thermodynamic	ADJ
admet-881	238	17	activity	activity	NOUN
admet-881	238	18	[	[	X
admet-881	238	19	39	39	NUM
admet-881	238	20	]	]	PUNCT
admet-881	238	21	.	.	PUNCT
admet-881	239	1	the	the	DET
admet-881	239	2	absorption	absorption	NOUN
admet-881	239	3	of	of	ADP
admet-881	239	4	bcs	bcs	NOUN
admet-881	239	5	class	class	NOUN
admet-881	239	6	ii	ii	NOUN
admet-881	239	7	drugs	drug	NOUN
admet-881	239	8	does	do	AUX
admet-881	239	9	not	not	PART
admet-881	239	10	necessarily	necessarily	ADV
admet-881	239	11	increase	increase	VERB
admet-881	239	12	when	when	SCONJ
admet-881	239	13	administered	administer	VERB
admet-881	239	14	with	with	ADP
admet-881	239	15	food	food	NOUN
admet-881	239	16	,	,	PUNCT
admet-881	239	17	as	as	SCONJ
admet-881	239	18	proposed	propose	VERB
admet-881	239	19	by	by	ADP
admet-881	239	20	others	other	NOUN
admet-881	239	21	[	[	X
admet-881	239	22	90	90	NUM
admet-881	239	23	]	]	PUNCT
admet-881	239	24	.	.	PUNCT
admet-881	240	1	taken	take	VERB
admet-881	240	2	together	together	ADV
admet-881	240	3	,	,	PUNCT
admet-881	240	4	these	these	PRON
admet-881	240	5	in	in	ADP
admet-881	240	6	vivo	vivo	ADJ
admet-881	240	7	data	datum	NOUN
admet-881	240	8	demonstrate	demonstrate	VERB
admet-881	240	9	that	that	SCONJ
admet-881	240	10	increasing	increase	VERB
admet-881	240	11	the	the	DET
admet-881	240	12	intestinal	intestinal	ADJ
admet-881	240	13	luminal	luminal	ADJ
admet-881	240	14	concentration	concentration	NOUN
admet-881	240	15	of	of	ADP
admet-881	240	16	bcs	bcs	NOUN
admet-881	240	17	class	class	NOUN
admet-881	240	18	ii	ii	NOUN
admet-881	240	19	drugs	drug	NOUN
admet-881	240	20	in	in	ADP
admet-881	240	21	complex	complex	ADJ
admet-881	240	22	intestinal	intestinal	ADJ
admet-881	240	23	fluids	fluid	NOUN
admet-881	240	24	does	do	AUX
admet-881	240	25	not	not	PART
admet-881	240	26	always	always	ADV
admet-881	240	27	result	result	VERB
admet-881	240	28	in	in	ADP
admet-881	240	29	more	more	ADV
admet-881	240	30	rapid	rapid	ADJ
admet-881	240	31	and	and	CCONJ
admet-881	240	32	extensive	extensive	ADJ
admet-881	240	33	intestinal	intestinal	ADJ
admet-881	240	34	absorption	absorption	NOUN
admet-881	240	35	.	.	PUNCT
admet-881	241	1	especially	especially	ADV
admet-881	241	2	in	in	ADP
admet-881	241	3	fed	fed	PROPN
admet-881	241	4	state	state	NOUN
admet-881	241	5	,	,	PUNCT
admet-881	241	6	the	the	DET
admet-881	241	7	encapsulation	encapsulation	NOUN
admet-881	241	8	of	of	ADP
admet-881	241	9	a	a	DET
admet-881	241	10	lipophilic	lipophilic	ADJ
admet-881	241	11	drug	drug	NOUN
admet-881	241	12	in	in	ADP
admet-881	241	13	micelles	micelle	NOUN
admet-881	241	14	and	and	CCONJ
admet-881	241	15	vesicles	vesicle	NOUN
admet-881	241	16	in	in	ADP
admet-881	241	17	the	the	DET
admet-881	241	18	intestinal	intestinal	ADJ
admet-881	241	19	lumen	luman	NOUN
admet-881	241	20	may	may	AUX
admet-881	241	21	reduce	reduce	VERB
admet-881	241	22	the	the	DET
admet-881	241	23	potential	potential	NOUN
admet-881	241	24	for	for	ADP
admet-881	241	25	intestinal	intestinal	ADJ
admet-881	241	26	flux	flux	NOUN
admet-881	241	27	.	.	PUNCT
admet-881	242	1	conclusion	conclusion	VERB
admet-881	242	2	the	the	DET
admet-881	242	3	use	use	NOUN
admet-881	242	4	of	of	ADP
admet-881	242	5	oral	oral	ADJ
admet-881	242	6	,	,	PUNCT
admet-881	242	7	nanosystems	nanosystem	VERB
admet-881	242	8	for	for	ADP
admet-881	242	9	drug	drug	NOUN
admet-881	242	10	delivery	delivery	NOUN
admet-881	242	11	can	can	AUX
admet-881	242	12	increase	increase	VERB
admet-881	242	13	intestinal	intestinal	ADJ
admet-881	242	14	absorption	absorption	NOUN
admet-881	242	15	and	and	CCONJ
admet-881	242	16	bioavailability	bioavailability	NOUN
admet-881	242	17	,	,	PUNCT
admet-881	242	18	reduce	reduce	VERB
admet-881	242	19	the	the	DET
admet-881	242	20	risk	risk	NOUN
admet-881	242	21	for	for	ADP
admet-881	242	22	food	food	NOUN
admet-881	242	23	–	–	PUNCT
admet-881	242	24	drug	drug	NOUN
admet-881	242	25	interactions	interaction	NOUN
admet-881	242	26	,	,	PUNCT
admet-881	242	27	and	and	CCONJ
admet-881	242	28	ph	ph	ADJ
admet-881	242	29	-	-	ADJ
admet-881	242	30	dependent	dependent	ADJ
admet-881	242	31	intestinal	intestinal	ADJ
admet-881	242	32	absorption	absorption	NOUN
admet-881	242	33	.	.	PUNCT
admet-881	243	1	however	however	ADV
admet-881	243	2	,	,	PUNCT
admet-881	243	3	for	for	ADP
admet-881	243	4	some	some	DET
admet-881	243	5	drugs	drug	NOUN
admet-881	243	6	,	,	PUNCT
admet-881	243	7	the	the	DET
admet-881	243	8	interaction	interaction	NOUN
admet-881	243	9	with	with	ADP
admet-881	243	10	colloidal	colloidal	NOUN
admet-881	243	11	structures	structure	NOUN
admet-881	243	12	in	in	ADP
admet-881	243	13	the	the	DET
admet-881	243	14	lumen	luman	NOUN
admet-881	243	15	may	may	AUX
admet-881	243	16	prevent	prevent	VERB
admet-881	243	17	absorption	absorption	NOUN
admet-881	243	18	even	even	ADV
admet-881	243	19	if	if	SCONJ
admet-881	243	20	the	the	DET
admet-881	243	21	oral	oral	ADJ
admet-881	243	22	nanosystems	nanosystem	NOUN
admet-881	243	23	enhance	enhance	VERB
admet-881	243	24	dissolution	dissolution	NOUN
admet-881	243	25	in	in	ADP
admet-881	243	26	vitro	vitro	X
admet-881	243	27	compared	compare	VERB
admet-881	243	28	to	to	ADP
admet-881	243	29	the	the	DET
admet-881	243	30	standard	standard	ADJ
admet-881	243	31	oral	oral	ADJ
admet-881	243	32	formulation	formulation	NOUN
admet-881	243	33	.	.	PUNCT
admet-881	244	1	nevertheless	nevertheless	ADV
admet-881	244	2	,	,	PUNCT
admet-881	244	3	nanoparticle	nanoparticle	NOUN
admet-881	244	4	formulations	formulation	NOUN
admet-881	244	5	offer	offer	VERB
admet-881	244	6	an	an	DET
admet-881	244	7	important	important	ADJ
admet-881	244	8	strategy	strategy	NOUN
admet-881	244	9	in	in	ADP
admet-881	244	10	the	the	DET
admet-881	244	11	development	development	NOUN
admet-881	244	12	of	of	ADP
admet-881	244	13	new	new	ADJ
admet-881	244	14	drugs	drug	NOUN
admet-881	244	15	and	and	CCONJ
admet-881	244	16	for	for	ADP
admet-881	244	17	currently	currently	ADV
admet-881	244	18	difficult	difficult	ADJ
admet-881	244	19	poorly	poorly	ADV
admet-881	244	20	soluble	soluble	ADJ
admet-881	244	21	drugs	drug	NOUN
admet-881	244	22	.	.	PUNCT
admet-881	245	1	conflict	conflict	NOUN
admet-881	245	2	of	of	ADP
admet-881	245	3	interest	interest	NOUN
admet-881	245	4	:	:	PUNCT
admet-881	245	5	conflict	conflict	NOUN
admet-881	245	6	of	of	ADP
admet-881	245	7	interest	interest	NOUN
admet-881	245	8	does	do	AUX
admet-881	245	9	not	not	PART
admet-881	245	10	exist	exist	VERB
admet-881	245	11	.	.	PUNCT
admet-881	246	1	references	reference	NOUN
admet-881	246	2	[	[	X
admet-881	246	3	1	1	NUM
admet-881	246	4	]	]	PUNCT
admet-881	246	5	b.	b.	PROPN
admet-881	246	6	abrahamsson	abrahamsson	PROPN
admet-881	246	7	,	,	PUNCT
admet-881	246	8	m.	m.	NOUN
admet-881	246	9	mcallister	mcallister	PROPN
admet-881	246	10	,	,	PUNCT
admet-881	246	11	p.	p.	NOUN
admet-881	246	12	augustijns	augustijns	NOUN
admet-881	246	13	,	,	PUNCT
admet-881	246	14	p.	p.	PROPN
admet-881	246	15	zane	zane	PROPN
admet-881	246	16	,	,	PUNCT
admet-881	246	17	j.	j.	PROPN
admet-881	246	18	butler	butler	PROPN
admet-881	246	19	,	,	PUNCT
admet-881	246	20	r.	r.	PROPN
admet-881	246	21	holm	holm	PROPN
admet-881	246	22	,	,	PUNCT
admet-881	246	23	p.	p.	PROPN
admet-881	246	24	langguth	langguth	PROPN
admet-881	246	25	,	,	PUNCT
admet-881	246	26	a.	a.	PROPN
admet-881	246	27	lindahl	lindahl	PROPN
admet-881	246	28	,	,	PUNCT
admet-881	246	29	a.	a.	NOUN
admet-881	246	30	müllertz	müllertz	PROPN
admet-881	246	31	,	,	PUNCT
admet-881	246	32	x.	x.	PROPN
admet-881	246	33	pepin	pepin	PROPN
admet-881	246	34	.	.	PUNCT
admet-881	247	1	six	six	NUM
admet-881	247	2	years	year	NOUN
admet-881	247	3	of	of	ADP
admet-881	247	4	progress	progress	NOUN
admet-881	247	5	in	in	ADP
admet-881	247	6	the	the	DET
admet-881	247	7	oral	oral	ADJ
admet-881	247	8	biopharmaceutics	biopharmaceutics	NOUN
admet-881	247	9	area	area	NOUN
admet-881	247	10	–	–	PUNCT
admet-881	247	11	a	a	DET
admet-881	247	12	summary	summary	NOUN
admet-881	247	13	from	from	ADP
admet-881	247	14	the	the	DET
admet-881	247	15	imi	imi	PROPN
admet-881	247	16	orbito	orbito	PROPN
admet-881	247	17	project	project	PROPN
admet-881	247	18	.	.	PUNCT
admet-881	248	1	european	european	PROPN
admet-881	248	2	journal	journal	PROPN
admet-881	248	3	of	of	ADP
admet-881	248	4	pharmaceutics	pharmaceutic	NOUN
admet-881	248	5	and	and	CCONJ
admet-881	248	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	248	7	(	(	PUNCT
admet-881	248	8	2020	2020	NUM
admet-881	248	9	)	)	PUNCT
admet-881	248	10	.	.	PUNCT
admet-881	249	1	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	PROPN
admet-881	249	2	h.	h.	PROPN
admet-881	249	3	lennernäs	lennernäs	PROPN
admet-881	249	4	et	et	PROPN
admet-881	249	5	al	al	PROPN
admet-881	249	6	.	.	PROPN
admet-881	249	7	admet	admet	PROPN
admet-881	249	8	&	&	CCONJ
admet-881	249	9	dmpk	dmpk	PROPN
admet-881	249	10	8(4	8(4	NOUN
admet-881	249	11	)	)	PUNCT
admet-881	249	12	(	(	PUNCT
admet-881	249	13	2020	2020	NUM
admet-881	249	14	)	)	PUNCT
admet-881	249	15	375	375	NUM
admet-881	249	16	-	-	SYM
admet-881	249	17	390	390	NUM
admet-881	249	18	386	386	NUM
admet-881	249	19	[	[	X
admet-881	249	20	2	2	NUM
admet-881	249	21	]	]	PUNCT
admet-881	249	22	e.	e.	PROPN
admet-881	249	23	sjögren	sjögren	PROPN
admet-881	249	24	,	,	PUNCT
admet-881	249	25	b.	b.	PROPN
admet-881	249	26	abrahamsson	abrahamsson	PROPN
admet-881	249	27	,	,	PUNCT
admet-881	249	28	p.	p.	NOUN
admet-881	249	29	augustijns	augustijns	NOUN
admet-881	249	30	,	,	PUNCT
admet-881	249	31	d.	d.	PROPN
admet-881	249	32	becker	becker	PROPN
admet-881	249	33	,	,	PUNCT
admet-881	249	34	m.b	m.b	PROPN
admet-881	249	35	.	.	PROPN
admet-881	249	36	bolger	bolger	PROPN
admet-881	249	37	,	,	PUNCT
admet-881	249	38	m.	m.	NOUN
admet-881	249	39	brewster	brewster	NOUN
admet-881	249	40	,	,	PUNCT
admet-881	249	41	j.	j.	PROPN
admet-881	249	42	brouwers	brouwers	PROPN
admet-881	249	43	,	,	PUNCT
admet-881	249	44	t.	t.	PROPN
admet-881	249	45	flanagan	flanagan	PROPN
admet-881	249	46	,	,	PUNCT
admet-881	249	47	m.	m.	NOUN
admet-881	249	48	harwood	harwood	PROPN
admet-881	249	49	,	,	PUNCT
admet-881	249	50	c.	c.	PROPN
admet-881	249	51	heinen	heinen	PROPN
admet-881	249	52	,	,	PUNCT
admet-881	249	53	r.	r.	PROPN
admet-881	249	54	holm	holm	PROPN
admet-881	249	55	,	,	PUNCT
admet-881	249	56	h.	h.	PROPN
admet-881	249	57	juretschke	juretschke	PROPN
admet-881	249	58	,	,	PUNCT
admet-881	249	59	m.	m.	NOUN
admet-881	249	60	kubbinga	kubbinga	PROPN
admet-881	249	61	,	,	PUNCT
admet-881	249	62	a.	a.	PROPN
admet-881	249	63	lindahl	lindahl	PROPN
admet-881	249	64	,	,	PUNCT
admet-881	249	65	v.	v.	PROPN
admet-881	249	66	lukacova	lukacova	PROPN
admet-881	249	67	,	,	PUNCT
admet-881	249	68	u.	u.	PROPN
admet-881	249	69	münster	münster	PROPN
admet-881	249	70	,	,	PUNCT
admet-881	249	71	s.	s.	PROPN
admet-881	249	72	neuhoff	neuhoff	PROPN
admet-881	249	73	,	,	PUNCT
admet-881	249	74	m.	m.	NOUN
admet-881	249	75	nguyen	nguyen	NOUN
admet-881	249	76	,	,	PUNCT
admet-881	249	77	a.	a.	NOUN
admet-881	249	78	peer	peer	NOUN
admet-881	249	79	,	,	PUNCT
admet-881	249	80	c.	c.	PROPN
admet-881	249	81	reppas	reppas	PROPN
admet-881	249	82	,	,	PUNCT
admet-881	249	83	a.	a.	NOUN
admet-881	249	84	hodjegan	hodjegan	PROPN
admet-881	249	85	,	,	PUNCT
admet-881	249	86	c.	c.	PROPN
admet-881	249	87	tannergren	tannergren	PROPN
admet-881	249	88	,	,	PUNCT
admet-881	249	89	w.	w.	PROPN
admet-881	249	90	weitschies	weitschie	NOUN
admet-881	249	91	,	,	PUNCT
admet-881	249	92	c.	c.	PROPN
admet-881	249	93	wilson	wilson	PROPN
admet-881	249	94	,	,	PUNCT
admet-881	249	95	p.	p.	PROPN
admet-881	249	96	zane	zane	PROPN
admet-881	249	97	,	,	PUNCT
admet-881	249	98	h.	h.	PROPN
admet-881	249	99	lennernäs	lennernäs	PROPN
admet-881	249	100	,	,	PUNCT
admet-881	249	101	p.	p.	PROPN
admet-881	249	102	langguth	langguth	NOUN
admet-881	249	103	.	.	PUNCT
admet-881	250	1	in	in	ADP
admet-881	250	2	vivo	vivo	ADJ
admet-881	250	3	methods	method	NOUN
admet-881	250	4	for	for	ADP
admet-881	250	5	drug	drug	NOUN
admet-881	250	6	absorption	absorption	NOUN
admet-881	250	7	–	–	PUNCT
admet-881	250	8	comparative	comparative	ADJ
admet-881	250	9	physiologies	physiology	NOUN
admet-881	250	10	,	,	PUNCT
admet-881	250	11	model	model	NOUN
admet-881	250	12	selection	selection	NOUN
admet-881	250	13	,	,	PUNCT
admet-881	250	14	correlations	correlation	NOUN
admet-881	250	15	with	with	ADP
admet-881	250	16	in	in	ADP
admet-881	250	17	vitro	vitro	X
admet-881	250	18	methods	method	NOUN
admet-881	250	19	(	(	PUNCT
admet-881	250	20	ivivc	ivivc	PROPN
admet-881	250	21	)	)	PUNCT
admet-881	250	22	,	,	PUNCT
admet-881	250	23	and	and	CCONJ
admet-881	250	24	applications	application	NOUN
admet-881	250	25	for	for	ADP
admet-881	250	26	formulation	formulation	NOUN
admet-881	250	27	/	/	SYM
admet-881	250	28	api	api	NOUN
admet-881	250	29	/	/	SYM
admet-881	250	30	excipient	excipient	ADJ
admet-881	250	31	characterization	characterization	NOUN
admet-881	250	32	including	include	VERB
admet-881	250	33	food	food	NOUN
admet-881	250	34	effects	effect	NOUN
admet-881	250	35	.	.	PUNCT
admet-881	251	1	european	european	PROPN
admet-881	251	2	journal	journal	PROPN
admet-881	251	3	of	of	ADP
admet-881	251	4	pharmaceutical	pharmaceutical	PROPN
admet-881	251	5	sciences	science	NOUN
admet-881	251	6	57	57	NUM
admet-881	251	7	(	(	PUNCT
admet-881	251	8	2014	2014	NUM
admet-881	251	9	)	)	PUNCT
admet-881	251	10	99	99	NUM
admet-881	251	11	-	-	SYM
admet-881	251	12	151	151	NUM
admet-881	251	13	.	.	PUNCT
admet-881	252	1	[	[	X
admet-881	252	2	3	3	NUM
admet-881	252	3	]	]	X
admet-881	252	4	g.l	g.l	PROPN
admet-881	252	5	.	.	PROPN
admet-881	252	6	amidon	amidon	PROPN
admet-881	252	7	,	,	PUNCT
admet-881	252	8	h.	h.	PROPN
admet-881	252	9	lennernas	lennernas	PROPN
admet-881	252	10	,	,	PUNCT
admet-881	252	11	v.p	v.p	PROPN
admet-881	252	12	.	.	PROPN
admet-881	252	13	shah	shah	PROPN
admet-881	252	14	,	,	PUNCT
admet-881	252	15	j.r	j.r	PROPN
admet-881	252	16	.	.	PROPN
admet-881	252	17	crison	crison	PROPN
admet-881	252	18	.	.	PUNCT
admet-881	253	1	a	a	DET
admet-881	253	2	theoretical	theoretical	ADJ
admet-881	253	3	basis	basis	NOUN
admet-881	253	4	for	for	ADP
admet-881	253	5	a	a	DET
admet-881	253	6	biopharmaceutic	biopharmaceutic	ADJ
admet-881	253	7	drug	drug	NOUN
admet-881	253	8	classification	classification	NOUN
admet-881	253	9	:	:	PUNCT
admet-881	253	10	the	the	DET
admet-881	253	11	correlation	correlation	NOUN
admet-881	253	12	of	of	ADP
admet-881	253	13	in	in	ADP
admet-881	253	14	vitro	vitro	X
admet-881	253	15	drug	drug	NOUN
admet-881	253	16	product	product	NOUN
admet-881	253	17	dissolution	dissolution	NOUN
admet-881	253	18	and	and	CCONJ
admet-881	253	19	in	in	ADP
admet-881	253	20	vivo	vivo	ADJ
admet-881	253	21	bioavailability	bioavailability	NOUN
admet-881	253	22	.	.	PUNCT
admet-881	254	1	pharmaceutical	pharmaceutical	ADJ
admet-881	254	2	research	research	NOUN
admet-881	254	3	12	12	NUM
admet-881	254	4	(	(	PUNCT
admet-881	254	5	1995	1995	NUM
admet-881	254	6	)	)	PUNCT
admet-881	254	7	413	413	NUM
admet-881	254	8	-	-	SYM
admet-881	254	9	420	420	NUM
admet-881	254	10	.	.	PUNCT
admet-881	255	1	[	[	X
admet-881	255	2	4	4	NUM
admet-881	255	3	]	]	X
admet-881	255	4	e.t	e.t	PROPN
admet-881	255	5	.	.	PROPN
admet-881	255	6	hellriegel	hellriegel	PROPN
admet-881	255	7	,	,	PUNCT
admet-881	255	8	t.d	t.d	PROPN
admet-881	255	9	.	.	PROPN
admet-881	255	10	bjornsson	bjornsson	PROPN
admet-881	255	11	.	.	PUNCT
admet-881	256	1	interpatient	interpatient	ADJ
admet-881	256	2	variability	variability	NOUN
admet-881	256	3	in	in	ADP
admet-881	256	4	bioavailability	bioavailability	NOUN
admet-881	256	5	is	be	AUX
admet-881	256	6	related	relate	VERB
admet-881	256	7	to	to	ADP
admet-881	256	8	the	the	DET
admet-881	256	9	extent	extent	NOUN
admet-881	256	10	of	of	ADP
admet-881	256	11	absorption	absorption	NOUN
admet-881	256	12	:	:	PUNCT
admet-881	256	13	implications	implication	NOUN
admet-881	256	14	for	for	ADP
admet-881	256	15	bioavailability	bioavailability	NOUN
admet-881	256	16	and	and	CCONJ
admet-881	256	17	bioequivalence	bioequivalence	NOUN
admet-881	256	18	studies	study	NOUN
admet-881	256	19	.	.	PUNCT
admet-881	257	1	clinical	clinical	ADJ
admet-881	257	2	pharmacology	pharmacology	NOUN
admet-881	257	3	and	and	CCONJ
admet-881	257	4	therapeutics	therapeutic	NOUN
admet-881	257	5	60	60	NUM
admet-881	257	6	(	(	PUNCT
admet-881	257	7	1996	1996	NUM
admet-881	257	8	)	)	PUNCT
admet-881	257	9	601	601	NUM
admet-881	257	10	-	-	NUM
admet-881	257	11	607	607	NUM
admet-881	257	12	.	.	PUNCT
admet-881	258	1	[	[	X
admet-881	258	2	5	5	NUM
admet-881	258	3	]	]	PUNCT
admet-881	258	4	m.	m.	NOUN
admet-881	258	5	sugihara	sugihara	NOUN
admet-881	258	6	,	,	PUNCT
admet-881	258	7	s.	s.	PROPN
admet-881	258	8	takeuchi	takeuchi	PROPN
admet-881	258	9	,	,	PUNCT
admet-881	258	10	m.	m.	NOUN
admet-881	258	11	sugita	sugita	PROPN
admet-881	258	12	,	,	PUNCT
admet-881	258	13	k.	k.	PROPN
admet-881	258	14	higaki	higaki	PROPN
admet-881	258	15	,	,	PUNCT
admet-881	258	16	m.	m.	NOUN
admet-881	258	17	kataoka	kataoka	PROPN
admet-881	258	18	,	,	PUNCT
admet-881	258	19	s.	s.	PROPN
admet-881	258	20	yamashita	yamashita	PROPN
admet-881	258	21	.	.	PUNCT
admet-881	259	1	analysis	analysis	NOUN
admet-881	259	2	of	of	ADP
admet-881	259	3	intra	intra	ADJ
admet-881	259	4	-	-	ADJ
admet-881	259	5	and	and	CCONJ
admet-881	259	6	intersubject	intersubject	ADJ
admet-881	259	7	variability	variability	NOUN
admet-881	259	8	in	in	ADP
admet-881	259	9	oral	oral	ADJ
admet-881	259	10	drug	drug	NOUN
admet-881	259	11	absorption	absorption	NOUN
admet-881	259	12	in	in	ADP
admet-881	259	13	human	human	ADJ
admet-881	259	14	bioequivalence	bioequivalence	NOUN
admet-881	259	15	studies	study	NOUN
admet-881	259	16	of	of	ADP
admet-881	259	17	113	113	NUM
admet-881	259	18	generic	generic	ADJ
admet-881	259	19	products	product	NOUN
admet-881	259	20	.	.	PUNCT
admet-881	260	1	molecular	molecular	ADJ
admet-881	260	2	pharmaceutics	pharmaceutic	NOUN
admet-881	260	3	12	12	NUM
admet-881	260	4	(	(	PUNCT
admet-881	260	5	2015	2015	NUM
admet-881	260	6	)	)	PUNCT
admet-881	260	7	4405	4405	NUM
admet-881	260	8	-	-	SYM
admet-881	260	9	4413	4413	NUM
admet-881	260	10	.	.	PUNCT
admet-881	261	1	[	[	X
admet-881	261	2	6	6	NUM
admet-881	261	3	]	]	X
admet-881	261	4	c.y	c.y	PROPN
admet-881	261	5	.	.	PROPN
admet-881	261	6	wu	wu	PROPN
admet-881	261	7	,	,	PUNCT
admet-881	261	8	l.z	l.z	PROPN
admet-881	261	9	.	.	PROPN
admet-881	261	10	benet	benet	PROPN
admet-881	261	11	,	,	PUNCT
admet-881	261	12	m.f	m.f	PROPN
admet-881	261	13	.	.	PUNCT
admet-881	261	14	hebert	hebert	PROPN
admet-881	261	15	,	,	PUNCT
admet-881	261	16	s.k	s.k	PROPN
admet-881	261	17	.	.	PROPN
admet-881	261	18	gupta	gupta	PROPN
admet-881	261	19	,	,	PUNCT
admet-881	261	20	m.	m.	NOUN
admet-881	261	21	rowland	rowland	PROPN
admet-881	261	22	,	,	PUNCT
admet-881	261	23	d.y	d.y	PROPN
admet-881	261	24	.	.	PROPN
admet-881	261	25	gomez	gomez	PROPN
admet-881	261	26	,	,	PUNCT
admet-881	261	27	v.j	v.j	PROPN
admet-881	261	28	.	.	PROPN
admet-881	261	29	wacher	wacher	PROPN
admet-881	261	30	.	.	PUNCT
admet-881	262	1	differentiation	differentiation	NOUN
admet-881	262	2	of	of	ADP
admet-881	262	3	absorption	absorption	NOUN
admet-881	262	4	and	and	CCONJ
admet-881	262	5	first‐pass	first‐pass	NOUN
admet-881	262	6	gut	gut	NOUN
admet-881	262	7	and	and	CCONJ
admet-881	262	8	hepatic	hepatic	ADJ
admet-881	262	9	metabolism	metabolism	NOUN
admet-881	262	10	in	in	ADP
admet-881	262	11	humans	human	NOUN
admet-881	262	12	:	:	PUNCT
admet-881	262	13	studies	study	NOUN
admet-881	262	14	with	with	ADP
admet-881	262	15	cyclosporine	cyclosporine	NOUN
admet-881	262	16	.	.	PUNCT
admet-881	263	1	clinical	clinical	ADJ
admet-881	263	2	pharmacology	pharmacology	NOUN
admet-881	263	3	and	and	CCONJ
admet-881	263	4	therapeutics	therapeutic	NOUN
admet-881	263	5	58	58	NUM
admet-881	263	6	(	(	PUNCT
admet-881	263	7	1995	1995	NUM
admet-881	263	8	)	)	PUNCT
admet-881	263	9	492	492	NUM
admet-881	263	10	-	-	SYM
admet-881	263	11	497	497	NUM
admet-881	263	12	.	.	PUNCT
admet-881	264	1	[	[	X
admet-881	264	2	7	7	X
admet-881	264	3	]	]	X
admet-881	264	4	h.h	h.h	PROPN
admet-881	264	5	.	.	PROPN
admet-881	264	6	refsgaard	refsgaard	PROPN
admet-881	264	7	,	,	PUNCT
admet-881	264	8	b.f	b.f	PROPN
admet-881	264	9	.	.	PROPN
admet-881	264	10	jensen	jensen	PROPN
admet-881	264	11	,	,	PUNCT
admet-881	264	12	p.b	p.b	PROPN
admet-881	264	13	.	.	PROPN
admet-881	264	14	brockhoff	brockhoff	PROPN
admet-881	264	15	,	,	PUNCT
admet-881	264	16	s.b	s.b	PROPN
admet-881	264	17	.	.	PROPN
admet-881	264	18	padkjær	padkjær	NOUN
admet-881	264	19	,	,	PUNCT
admet-881	264	20	m.	m.	NOUN
admet-881	264	21	guldbrandt	guldbrandt	PROPN
admet-881	264	22	,	,	PUNCT
admet-881	264	23	m.s	m.s	PROPN
admet-881	264	24	.	.	PROPN
admet-881	264	25	christensen	christensen	PROPN
admet-881	264	26	.	.	PUNCT
admet-881	265	1	in	in	ADP
admet-881	265	2	silico	silico	NOUN
admet-881	265	3	prediction	prediction	NOUN
admet-881	265	4	of	of	ADP
admet-881	265	5	membrane	membrane	NOUN
admet-881	265	6	permeability	permeability	NOUN
admet-881	265	7	from	from	ADP
admet-881	265	8	calculated	calculate	VERB
admet-881	265	9	molecular	molecular	ADJ
admet-881	265	10	parameters	parameter	NOUN
admet-881	265	11	.	.	PUNCT
admet-881	266	1	j	j	PROPN
admet-881	266	2	med	med	PROPN
admet-881	266	3	chem	chem	NOUN
admet-881	266	4	48	48	NUM
admet-881	266	5	(	(	PUNCT
admet-881	266	6	2005	2005	NUM
admet-881	266	7	)	)	PUNCT
admet-881	266	8	805	805	NUM
admet-881	266	9	-	-	SYM
admet-881	266	10	811	811	NUM
admet-881	266	11	.	.	PUNCT
admet-881	267	1	[	[	X
admet-881	267	2	8	8	NUM
admet-881	267	3	]	]	X
admet-881	267	4	e.	e.	PROPN
admet-881	267	5	sjögren	sjögren	PROPN
admet-881	267	6	,	,	PUNCT
admet-881	267	7	j.	j.	PROPN
admet-881	267	8	westergren	westergren	PROPN
admet-881	267	9	,	,	PUNCT
admet-881	267	10	i.	i.	PROPN
admet-881	267	11	grant	grant	PROPN
admet-881	267	12	,	,	PUNCT
admet-881	267	13	g.	g.	PROPN
admet-881	267	14	hanisch	hanisch	PROPN
admet-881	267	15	,	,	PUNCT
admet-881	267	16	l.	l.	PROPN
admet-881	267	17	lindfors	lindfors	PROPN
admet-881	267	18	,	,	PUNCT
admet-881	267	19	h.	h.	PROPN
admet-881	267	20	lennernäs	lennernäs	PROPN
admet-881	267	21	,	,	PUNCT
admet-881	267	22	b.	b.	PROPN
admet-881	267	23	abrahamsson	abrahamsson	PROPN
admet-881	267	24	,	,	PUNCT
admet-881	267	25	c.	c.	PROPN
admet-881	267	26	tannergren	tannergren	PROPN
admet-881	267	27	.	.	PUNCT
admet-881	268	1	in	in	ADP
admet-881	268	2	silico	silico	NOUN
admet-881	268	3	predictions	prediction	NOUN
admet-881	268	4	of	of	ADP
admet-881	268	5	gastrointestinal	gastrointestinal	ADJ
admet-881	268	6	drug	drug	NOUN
admet-881	268	7	absorption	absorption	NOUN
admet-881	268	8	in	in	ADP
admet-881	268	9	pharmaceutical	pharmaceutical	ADJ
admet-881	268	10	product	product	NOUN
admet-881	268	11	development	development	NOUN
admet-881	268	12	:	:	PUNCT
admet-881	268	13	application	application	NOUN
admet-881	268	14	of	of	ADP
admet-881	268	15	the	the	DET
admet-881	268	16	mechanistic	mechanistic	ADJ
admet-881	268	17	absorption	absorption	NOUN
admet-881	268	18	model	model	NOUN
admet-881	268	19	gi	gi	NOUN
admet-881	268	20	-	-	PUNCT
admet-881	268	21	sim	sim	NOUN
admet-881	268	22	.	.	PUNCT
admet-881	269	1	european	european	PROPN
admet-881	269	2	journal	journal	PROPN
admet-881	269	3	of	of	ADP
admet-881	269	4	pharmaceutical	pharmaceutical	PROPN
admet-881	269	5	sciences	science	NOUN
admet-881	269	6	49	49	NUM
admet-881	269	7	(	(	PUNCT
admet-881	269	8	2013	2013	NUM
admet-881	269	9	)	)	PUNCT
admet-881	269	10	679	679	NUM
admet-881	269	11	-	-	NUM
admet-881	269	12	698	698	NUM
admet-881	269	13	.	.	PUNCT
admet-881	270	1	[	[	X
admet-881	270	2	9	9	NUM
admet-881	270	3	]	]	X
admet-881	270	4	h.d	h.d	PROPN
admet-881	270	5	.	.	PROPN
admet-881	270	6	williams	williams	PROPN
admet-881	270	7	,	,	PUNCT
admet-881	270	8	n.l	n.l	PROPN
admet-881	270	9	.	.	PROPN
admet-881	270	10	trevaskis	trevaskis	PROPN
admet-881	270	11	,	,	PUNCT
admet-881	270	12	s.a	s.a	PROPN
admet-881	270	13	.	.	PROPN
admet-881	270	14	charman	charman	PROPN
admet-881	270	15	,	,	PUNCT
admet-881	270	16	r.m	r.m	PROPN
admet-881	270	17	.	.	PROPN
admet-881	270	18	shanker	shanker	PROPN
admet-881	270	19	,	,	PUNCT
admet-881	270	20	w.n	w.n	PROPN
admet-881	270	21	.	.	PROPN
admet-881	270	22	charman	charman	PROPN
admet-881	270	23	,	,	PUNCT
admet-881	270	24	c.w	c.w	PROPN
admet-881	270	25	.	.	PROPN
admet-881	270	26	pouton	pouton	PROPN
admet-881	270	27	,	,	PUNCT
admet-881	270	28	c.j	c.j	PROPN
admet-881	270	29	.	.	PROPN
admet-881	270	30	porter	porter	NOUN
admet-881	270	31	.	.	PUNCT
admet-881	271	1	strategies	strategy	NOUN
admet-881	271	2	to	to	PART
admet-881	271	3	address	address	VERB
admet-881	271	4	low	low	ADJ
admet-881	271	5	drug	drug	NOUN
admet-881	271	6	solubility	solubility	NOUN
admet-881	271	7	in	in	ADP
admet-881	271	8	discovery	discovery	NOUN
admet-881	271	9	and	and	CCONJ
admet-881	271	10	development	development	NOUN
admet-881	271	11	.	.	PUNCT
admet-881	272	1	pharmacological	pharmacological	ADJ
admet-881	272	2	reviews	review	NOUN
admet-881	272	3	65	65	NUM
admet-881	272	4	(	(	PUNCT
admet-881	272	5	2013	2013	NUM
admet-881	272	6	)	)	PUNCT
admet-881	272	7	315	315	NUM
admet-881	272	8	-	-	SYM
admet-881	272	9	499	499	NUM
admet-881	272	10	.	.	PUNCT
admet-881	273	1	[	[	X
admet-881	273	2	10	10	NUM
admet-881	273	3	]	]	X
admet-881	273	4	c.a	c.a	PROPN
admet-881	273	5	.	.	PROPN
admet-881	273	6	lipinski	lipinski	PROPN
admet-881	273	7	.	.	PUNCT
admet-881	273	8	drug	drug	NOUN
admet-881	273	9	-	-	PUNCT
admet-881	273	10	like	like	ADJ
admet-881	273	11	properties	property	NOUN
admet-881	273	12	and	and	CCONJ
admet-881	273	13	the	the	DET
admet-881	273	14	causes	cause	NOUN
admet-881	273	15	of	of	ADP
admet-881	273	16	poor	poor	ADJ
admet-881	273	17	solubility	solubility	NOUN
admet-881	273	18	and	and	CCONJ
admet-881	273	19	poor	poor	ADJ
admet-881	273	20	permeability	permeability	NOUN
admet-881	273	21	.	.	PUNCT
admet-881	274	1	journal	journal	NOUN
admet-881	274	2	of	of	ADP
admet-881	274	3	pharmacological	pharmacological	ADJ
admet-881	274	4	and	and	CCONJ
admet-881	274	5	toxicological	toxicological	ADJ
admet-881	274	6	methods	method	NOUN
admet-881	274	7	44	44	NUM
admet-881	274	8	(	(	PUNCT
admet-881	274	9	2000	2000	NUM
admet-881	274	10	)	)	PUNCT
admet-881	274	11	235	235	NUM
admet-881	274	12	-	-	SYM
admet-881	274	13	249	249	NUM
admet-881	274	14	.	.	PUNCT
admet-881	275	1	[	[	X
admet-881	275	2	11	11	NUM
admet-881	275	3	]	]	X
admet-881	275	4	p.w	p.w	PROPN
admet-881	275	5	.	.	PUNCT
admet-881	275	6	kenny	kenny	PROPN
admet-881	275	7	.	.	PUNCT
admet-881	276	1	the	the	DET
admet-881	276	2	nature	nature	NOUN
admet-881	276	3	of	of	ADP
admet-881	276	4	ligand	ligand	ADJ
admet-881	276	5	efficiency	efficiency	NOUN
admet-881	276	6	.	.	PUNCT
admet-881	277	1	journal	journal	PROPN
admet-881	277	2	of	of	ADP
admet-881	277	3	cheminformatics	cheminformatic	NOUN
admet-881	277	4	11	11	NUM
admet-881	277	5	(	(	PUNCT
admet-881	277	6	2019	2019	NUM
admet-881	277	7	)	)	PUNCT
admet-881	277	8	1	1	NUM
admet-881	277	9	-	-	SYM
admet-881	277	10	18	18	NUM
admet-881	277	11	.	.	PUNCT
admet-881	278	1	[	[	X
admet-881	278	2	12	12	NUM
admet-881	278	3	]	]	X
admet-881	278	4	m.m	m.m	PROPN
admet-881	278	5	.	.	PROPN
admet-881	278	6	hann	hann	PROPN
admet-881	278	7	,	,	PUNCT
admet-881	278	8	a.r	a.r	PROPN
admet-881	278	9	.	.	PROPN
admet-881	278	10	leach	leach	NOUN
admet-881	278	11	,	,	PUNCT
admet-881	278	12	g.	g.	PROPN
admet-881	278	13	harper	harper	PROPN
admet-881	278	14	.	.	PUNCT
admet-881	279	1	molecular	molecular	ADJ
admet-881	279	2	complexity	complexity	NOUN
admet-881	279	3	and	and	CCONJ
admet-881	279	4	its	its	PRON
admet-881	279	5	impact	impact	NOUN
admet-881	279	6	on	on	ADP
admet-881	279	7	the	the	DET
admet-881	279	8	probability	probability	NOUN
admet-881	279	9	of	of	ADP
admet-881	279	10	finding	finding	NOUN
admet-881	279	11	leads	lead	VERB
admet-881	279	12	for	for	ADP
admet-881	279	13	drug	drug	NOUN
admet-881	279	14	discovery	discovery	NOUN
admet-881	279	15	.	.	PUNCT
admet-881	280	1	journal	journal	PROPN
admet-881	280	2	of	of	ADP
admet-881	280	3	chemical	chemical	ADJ
admet-881	280	4	information	information	NOUN
admet-881	280	5	and	and	CCONJ
admet-881	280	6	computer	computer	NOUN
admet-881	280	7	sciences	science	NOUN
admet-881	280	8	41	41	NUM
admet-881	280	9	(	(	PUNCT
admet-881	280	10	2001	2001	NUM
admet-881	280	11	)	)	PUNCT
admet-881	280	12	856	856	NUM
admet-881	280	13	-	-	SYM
admet-881	280	14	864	864	NUM
admet-881	280	15	.	.	PUNCT
admet-881	281	1	[	[	X
admet-881	281	2	13	13	NUM
admet-881	281	3	]	]	X
admet-881	281	4	c.	c.	PROPN
admet-881	281	5	lipinski	lipinski	PROPN
admet-881	281	6	.	.	PUNCT
admet-881	282	1	poor	poor	ADJ
admet-881	282	2	aqueous	aqueous	ADJ
admet-881	282	3	solubility	solubility	NOUN
admet-881	282	4	—	—	PUNCT
admet-881	282	5	an	an	DET
admet-881	282	6	industry	industry	NOUN
admet-881	282	7	wide	wide	ADJ
admet-881	282	8	problem	problem	NOUN
admet-881	282	9	in	in	ADP
admet-881	282	10	drug	drug	NOUN
admet-881	282	11	discovery	discovery	NOUN
admet-881	282	12	.	.	PUNCT
admet-881	283	1	am	be	AUX
admet-881	283	2	pharm	pharm	PROPN
admet-881	283	3	rev	rev	X
admet-881	283	4	5	5	NUM
admet-881	283	5	(	(	PUNCT
admet-881	283	6	2002	2002	NUM
admet-881	283	7	)	)	PUNCT
admet-881	283	8	82	82	NUM
admet-881	283	9	-	-	SYM
admet-881	283	10	85	85	NUM
admet-881	283	11	.	.	PUNCT
admet-881	284	1	[	[	X
admet-881	284	2	14	14	NUM
admet-881	284	3	]	]	X
admet-881	284	4	a.a	a.a	PROPN
admet-881	284	5	.	.	PROPN
admet-881	284	6	noyes	noyes	PROPN
admet-881	284	7	,	,	PUNCT
admet-881	284	8	w.r	w.r	PROPN
admet-881	284	9	.	.	PROPN
admet-881	284	10	whitney	whitney	PROPN
admet-881	284	11	.	.	PUNCT
admet-881	285	1	the	the	DET
admet-881	285	2	rate	rate	NOUN
admet-881	285	3	of	of	ADP
admet-881	285	4	solution	solution	NOUN
admet-881	285	5	of	of	ADP
admet-881	285	6	solid	solid	ADJ
admet-881	285	7	substances	substance	NOUN
admet-881	285	8	in	in	ADP
admet-881	285	9	their	their	PRON
admet-881	285	10	own	own	ADJ
admet-881	285	11	solutions	solution	NOUN
admet-881	285	12	.	.	PUNCT
admet-881	286	1	journal	journal	NOUN
admet-881	286	2	of	of	ADP
admet-881	286	3	the	the	DET
admet-881	286	4	american	american	PROPN
admet-881	286	5	chemical	chemical	PROPN
admet-881	286	6	society	society	PROPN
admet-881	286	7	19	19	NUM
admet-881	286	8	(	(	PUNCT
admet-881	286	9	1897	1897	NUM
admet-881	286	10	)	)	PUNCT
admet-881	286	11	930	930	NUM
admet-881	286	12	-	-	SYM
admet-881	286	13	934	934	NUM
admet-881	286	14	.	.	PUNCT
admet-881	287	1	[	[	X
admet-881	287	2	15	15	NUM
admet-881	287	3	]	]	X
admet-881	287	4	e.	e.	PROPN
admet-881	287	5	brunner	brunner	PROPN
admet-881	287	6	.	.	PUNCT
admet-881	288	1	reaktionsgeschwindigkeit	reaktionsgeschwindigkeit	NOUN
admet-881	288	2	in	in	ADP
admet-881	288	3	heterogenen	heterogenen	PROPN
admet-881	288	4	systemen	systemen	NOUN
admet-881	288	5	.	.	PUNCT
admet-881	289	1	zeitschrift	zeitschrift	PROPN
admet-881	289	2	für	für	PROPN
admet-881	289	3	physikalische	physikalische	PROPN
admet-881	289	4	chemie	chemie	PROPN
admet-881	289	5	47	47	NUM
admet-881	289	6	(	(	PUNCT
admet-881	289	7	1904	1904	NUM
admet-881	289	8	)	)	PUNCT
admet-881	289	9	56	56	NUM
admet-881	289	10	-	-	SYM
admet-881	289	11	102	102	NUM
admet-881	289	12	.	.	PUNCT
admet-881	290	1	[	[	X
admet-881	290	2	16	16	NUM
admet-881	290	3	]	]	X
admet-881	290	4	d.a	d.a	PROPN
admet-881	290	5	.	.	PROPN
admet-881	290	6	shah	shah	PROPN
admet-881	290	7	,	,	PUNCT
admet-881	290	8	s.b	s.b	PROPN
admet-881	290	9	.	.	PROPN
admet-881	290	10	murdande	murdande	PROPN
admet-881	290	11	,	,	PUNCT
admet-881	290	12	r.h	r.h	PROPN
admet-881	290	13	.	.	PROPN
admet-881	290	14	dave	dave	PROPN
admet-881	290	15	.	.	PUNCT
admet-881	291	1	a	a	DET
admet-881	291	2	review	review	NOUN
admet-881	291	3	:	:	PUNCT
admet-881	291	4	pharmaceutical	pharmaceutical	NOUN
admet-881	291	5	and	and	CCONJ
admet-881	291	6	pharmacokinetic	pharmacokinetic	ADJ
admet-881	291	7	aspect	aspect	NOUN
admet-881	291	8	of	of	ADP
admet-881	291	9	nanocrystalline	nanocrystalline	ADJ
admet-881	291	10	suspensions	suspension	NOUN
admet-881	291	11	.	.	PUNCT
admet-881	292	1	journal	journal	NOUN
admet-881	292	2	of	of	ADP
admet-881	292	3	pharmaceutical	pharmaceutical	PROPN
admet-881	292	4	sciences	science	NOUN
admet-881	292	5	105	105	NUM
admet-881	292	6	(	(	PUNCT
admet-881	292	7	2016	2016	NUM
admet-881	292	8	)	)	PUNCT
admet-881	292	9	10	10	NUM
admet-881	292	10	-	-	SYM
admet-881	292	11	24	24	NUM
admet-881	292	12	.	.	PUNCT
admet-881	293	1	[	[	X
admet-881	293	2	17	17	NUM
admet-881	293	3	]	]	X
admet-881	293	4	j.b	j.b	PROPN
admet-881	293	5	.	.	PROPN
admet-881	293	6	dressman	dressman	PROPN
admet-881	293	7	,	,	PUNCT
admet-881	293	8	g.l	g.l	PROPN
admet-881	293	9	.	.	PROPN
admet-881	293	10	amidon	amidon	PROPN
admet-881	293	11	,	,	PUNCT
admet-881	293	12	c.	c.	PROPN
admet-881	293	13	reppas	reppas	PROPN
admet-881	293	14	,	,	PUNCT
admet-881	293	15	v.p	v.p	PROPN
admet-881	293	16	.	.	PROPN
admet-881	293	17	shah	shah	PROPN
admet-881	293	18	.	.	PUNCT
admet-881	294	1	dissolution	dissolution	PROPN
admet-881	294	2	testing	testing	NOUN
admet-881	294	3	as	as	ADP
admet-881	294	4	a	a	DET
admet-881	294	5	prognostic	prognostic	ADJ
admet-881	294	6	tool	tool	NOUN
admet-881	294	7	for	for	ADP
admet-881	294	8	oral	oral	ADJ
admet-881	294	9	drug	drug	NOUN
admet-881	294	10	absorption	absorption	NOUN
admet-881	294	11	:	:	PUNCT
admet-881	294	12	immediate	immediate	ADJ
admet-881	294	13	release	release	NOUN
admet-881	294	14	dosage	dosage	NOUN
admet-881	294	15	forms	form	NOUN
admet-881	294	16	.	.	PUNCT
admet-881	295	1	pharmaceutical	pharmaceutical	ADJ
admet-881	295	2	research	research	NOUN
admet-881	295	3	15	15	NUM
admet-881	295	4	(	(	PUNCT
admet-881	295	5	1998	1998	NUM
admet-881	295	6	)	)	PUNCT
admet-881	295	7	11	11	NUM
admet-881	295	8	-	-	SYM
admet-881	295	9	22	22	NUM
admet-881	295	10	.	.	PUNCT
admet-881	296	1	[	[	X
admet-881	296	2	18	18	NUM
admet-881	296	3	]	]	X
admet-881	296	4	b.	b.	PROPN
admet-881	296	5	shekunov	shekunov	PROPN
admet-881	296	6	,	,	PUNCT
admet-881	296	7	e.r	e.r	PROPN
admet-881	296	8	.	.	PROPN
admet-881	296	9	montgomery	montgomery	PROPN
admet-881	296	10	.	.	PUNCT
admet-881	297	1	theoretical	theoretical	ADJ
admet-881	297	2	analysis	analysis	NOUN
admet-881	297	3	of	of	ADP
admet-881	297	4	drug	drug	NOUN
admet-881	297	5	dissolution	dissolution	NOUN
admet-881	297	6	:	:	PUNCT
admet-881	297	7	i.	i.	PROPN
admet-881	297	8	solubility	solubility	NOUN
admet-881	297	9	and	and	CCONJ
admet-881	297	10	intrinsic	intrinsic	ADJ
admet-881	297	11	dissolution	dissolution	NOUN
admet-881	297	12	rate	rate	NOUN
admet-881	297	13	.	.	PUNCT
admet-881	298	1	journal	journal	PROPN
admet-881	298	2	of	of	ADP
admet-881	298	3	pharmaceutical	pharmaceutical	PROPN
admet-881	298	4	sciences	science	NOUN
admet-881	298	5	105	105	NUM
admet-881	298	6	(	(	PUNCT
admet-881	298	7	2016	2016	NUM
admet-881	298	8	)	)	PUNCT
admet-881	298	9	2685	2685	NUM
admet-881	298	10	-	-	SYM
admet-881	298	11	2697	2697	NUM
admet-881	298	12	.	.	PUNCT
admet-881	299	1	[	[	X
admet-881	299	2	19	19	NUM
admet-881	299	3	]	]	X
admet-881	299	4	j.	j.	PROPN
admet-881	299	5	siepmann	siepmann	PROPN
admet-881	299	6	,	,	PUNCT
admet-881	299	7	f.	f.	PROPN
admet-881	299	8	siepmann	siepmann	PROPN
admet-881	299	9	.	.	PUNCT
admet-881	300	1	mathematical	mathematical	ADJ
admet-881	300	2	modeling	modeling	NOUN
admet-881	300	3	of	of	ADP
admet-881	300	4	drug	drug	NOUN
admet-881	300	5	dissolution	dissolution	NOUN
admet-881	300	6	.	.	PUNCT
admet-881	301	1	international	international	ADJ
admet-881	301	2	journal	journal	PROPN
admet-881	301	3	of	of	ADP
admet-881	301	4	pharmaceutics	pharmaceutic	NOUN
admet-881	301	5	453	453	NUM
admet-881	301	6	(	(	PUNCT
admet-881	301	7	2013	2013	NUM
admet-881	301	8	)	)	PUNCT
admet-881	301	9	12	12	NUM
admet-881	301	10	-	-	SYM
admet-881	301	11	24	24	NUM
admet-881	301	12	.	.	PUNCT
admet-881	302	1	[	[	X
admet-881	302	2	20	20	NUM
admet-881	302	3	]	]	X
admet-881	302	4	v.b	v.b	PROPN
admet-881	302	5	.	.	PROPN
admet-881	302	6	junyaprasert	junyaprasert	PROPN
admet-881	302	7	,	,	PUNCT
admet-881	302	8	b.	b.	PROPN
admet-881	302	9	morakul	morakul	PROPN
admet-881	302	10	.	.	PUNCT
admet-881	303	1	nanocrystals	nanocrystal	NOUN
admet-881	303	2	for	for	ADP
admet-881	303	3	enhancement	enhancement	NOUN
admet-881	303	4	of	of	ADP
admet-881	303	5	oral	oral	ADJ
admet-881	303	6	bioavailability	bioavailability	NOUN
admet-881	303	7	of	of	ADP
admet-881	303	8	poorly	poorly	ADV
admet-881	303	9	watersoluble	watersoluble	ADJ
admet-881	303	10	drugs	drug	NOUN
admet-881	303	11	.	.	PUNCT
admet-881	304	1	asian	asian	ADJ
admet-881	304	2	journal	journal	PROPN
admet-881	304	3	of	of	ADP
admet-881	304	4	pharmaceutical	pharmaceutical	PROPN
admet-881	304	5	sciences	science	NOUN
admet-881	304	6	10	10	NUM
admet-881	304	7	(	(	PUNCT
admet-881	304	8	2015	2015	NUM
admet-881	304	9	)	)	PUNCT
admet-881	304	10	13	13	NUM
admet-881	304	11	-	-	SYM
admet-881	304	12	23	23	NUM
admet-881	304	13	.	.	PUNCT
admet-881	305	1	admet	admet	PROPN
admet-881	305	2	&	&	CCONJ
admet-881	305	3	dmpk	dmpk	PROPN
admet-881	305	4	8(4	8(4	NOUN
admet-881	305	5	)	)	PUNCT
admet-881	305	6	(	(	PUNCT
admet-881	305	7	2020	2020	NUM
admet-881	305	8	)	)	PUNCT
admet-881	305	9	375	375	NUM
admet-881	305	10	-	-	SYM
admet-881	305	11	390	390	NUM
admet-881	305	12	intestinal	intestinal	ADJ
admet-881	305	13	absorption	absorption	NOUN
admet-881	305	14	of	of	ADP
admet-881	305	15	bcs	bcs	NOUN
admet-881	305	16	class	class	NOUN
admet-881	305	17	ii	ii	PROPN
admet-881	305	18	drugs	drug	NOUN
admet-881	305	19	nanoparticles	nanoparticle	NOUN
admet-881	305	20	doi	doi	NOUN
admet-881	305	21	:	:	PUNCT
admet-881	305	22	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	305	23	387	387	NUM
admet-881	306	1	[	[	X
admet-881	306	2	21	21	NUM
admet-881	306	3	]	]	X
admet-881	306	4	r.h	r.h	PROPN
admet-881	306	5	.	.	PROPN
admet-881	306	6	müller	müller	PROPN
admet-881	306	7	,	,	PUNCT
admet-881	306	8	k.	k.	PROPN
admet-881	306	9	peters	peters	PROPN
admet-881	306	10	.	.	PUNCT
admet-881	307	1	nanosuspensions	nanosuspension	NOUN
admet-881	307	2	for	for	ADP
admet-881	307	3	the	the	DET
admet-881	307	4	formulation	formulation	NOUN
admet-881	307	5	of	of	ADP
admet-881	307	6	poorly	poorly	ADV
admet-881	307	7	soluble	soluble	ADJ
admet-881	307	8	drugs	drug	NOUN
admet-881	307	9	:	:	PUNCT
admet-881	307	10	i.	i.	NOUN
admet-881	307	11	preparation	preparation	NOUN
admet-881	307	12	by	by	ADP
admet-881	307	13	a	a	DET
admet-881	307	14	size	size	NOUN
admet-881	307	15	-	-	PUNCT
admet-881	307	16	reduction	reduction	NOUN
admet-881	307	17	technique	technique	NOUN
admet-881	307	18	.	.	PUNCT
admet-881	308	1	international	international	ADJ
admet-881	308	2	journal	journal	PROPN
admet-881	308	3	of	of	ADP
admet-881	308	4	pharmaceutics	pharmaceutic	NOUN
admet-881	308	5	160	160	NUM
admet-881	308	6	(	(	PUNCT
admet-881	308	7	1998	1998	NUM
admet-881	308	8	)	)	PUNCT
admet-881	308	9	229	229	NUM
admet-881	308	10	-	-	SYM
admet-881	308	11	237	237	NUM
admet-881	308	12	.	.	PUNCT
admet-881	309	1	[	[	X
admet-881	309	2	22	22	NUM
admet-881	309	3	]	]	X
admet-881	309	4	a.t	a.t	PROPN
admet-881	309	5	.	.	PUNCT
admet-881	309	6	serajuddin	serajuddin	PROPN
admet-881	309	7	.	.	PUNCT
admet-881	310	1	salt	salt	NOUN
admet-881	310	2	formation	formation	NOUN
admet-881	310	3	to	to	PART
admet-881	310	4	improve	improve	VERB
admet-881	310	5	drug	drug	NOUN
admet-881	310	6	solubility	solubility	NOUN
admet-881	310	7	.	.	PUNCT
admet-881	311	1	adv	adv	PROPN
admet-881	311	2	drug	drug	PROPN
admet-881	311	3	deliv	deliv	NOUN
admet-881	311	4	rev	rev	VERB
admet-881	311	5	59	59	NUM
admet-881	311	6	(	(	PUNCT
admet-881	311	7	2007	2007	NUM
admet-881	311	8	)	)	PUNCT
admet-881	311	9	603	603	NUM
admet-881	311	10	-	-	SYM
admet-881	311	11	616	616	NUM
admet-881	311	12	.	.	PUNCT
admet-881	312	1	[	[	X
admet-881	312	2	23	23	NUM
admet-881	312	3	]	]	PUNCT
admet-881	312	4	p.	p.	NOUN
admet-881	312	5	kanaujia	kanaujia	PROPN
admet-881	312	6	,	,	PUNCT
admet-881	312	7	p.	p.	PROPN
admet-881	312	8	poovizhi	poovizhi	PROPN
admet-881	312	9	,	,	PUNCT
admet-881	312	10	w.	w.	PROPN
admet-881	312	11	ng	ng	PROPN
admet-881	312	12	,	,	PUNCT
admet-881	312	13	r.	r.	PROPN
admet-881	312	14	tan	tan	PROPN
admet-881	312	15	.	.	PUNCT
admet-881	313	1	amorphous	amorphous	ADJ
admet-881	313	2	formulations	formulation	NOUN
admet-881	313	3	for	for	ADP
admet-881	313	4	dissolution	dissolution	NOUN
admet-881	313	5	and	and	CCONJ
admet-881	313	6	bioavailability	bioavailability	NOUN
admet-881	313	7	enhancement	enhancement	NOUN
admet-881	313	8	of	of	ADP
admet-881	313	9	poorly	poorly	ADV
admet-881	313	10	soluble	soluble	ADJ
admet-881	313	11	apis	apis	NOUN
admet-881	313	12	.	.	PUNCT
admet-881	314	1	powder	powder	NOUN
admet-881	314	2	technology	technology	NOUN
admet-881	314	3	285	285	NUM
admet-881	314	4	(	(	PUNCT
admet-881	314	5	2015	2015	NUM
admet-881	314	6	)	)	PUNCT
admet-881	314	7	2	2	NUM
admet-881	314	8	-	-	SYM
admet-881	314	9	15	15	NUM
admet-881	314	10	.	.	PUNCT
admet-881	315	1	[	[	X
admet-881	315	2	24	24	NUM
admet-881	315	3	]	]	X
admet-881	315	4	g.g	g.g	PROPN
admet-881	315	5	.	.	PROPN
admet-881	315	6	liversidge	liversidge	PROPN
admet-881	315	7	,	,	PUNCT
admet-881	315	8	k.c	k.c	PROPN
admet-881	315	9	.	.	PROPN
admet-881	315	10	cundy	cundy	PROPN
admet-881	315	11	.	.	PUNCT
admet-881	316	1	particle	particle	NOUN
admet-881	316	2	size	size	NOUN
admet-881	316	3	reduction	reduction	NOUN
admet-881	316	4	for	for	ADP
admet-881	316	5	improvement	improvement	NOUN
admet-881	316	6	of	of	ADP
admet-881	316	7	oral	oral	ADJ
admet-881	316	8	bioavailability	bioavailability	NOUN
admet-881	316	9	of	of	ADP
admet-881	316	10	hydrophobic	hydrophobic	NOUN
admet-881	316	11	drugs	drug	NOUN
admet-881	316	12	:	:	PUNCT
admet-881	316	13	i.	i.	PROPN
admet-881	316	14	absolute	absolute	ADJ
admet-881	316	15	oral	oral	ADJ
admet-881	316	16	bioavailability	bioavailability	NOUN
admet-881	316	17	of	of	ADP
admet-881	316	18	nanocrystalline	nanocrystalline	NOUN
admet-881	316	19	danazol	danazol	VERB
admet-881	316	20	in	in	ADP
admet-881	316	21	beagle	beagle	NOUN
admet-881	316	22	dogs	dog	NOUN
admet-881	316	23	.	.	PUNCT
admet-881	317	1	international	international	ADJ
admet-881	317	2	journal	journal	PROPN
admet-881	317	3	of	of	ADP
admet-881	317	4	pharmaceutics	pharmaceutic	NOUN
admet-881	317	5	125	125	NUM
admet-881	317	6	(	(	PUNCT
admet-881	317	7	1995	1995	NUM
admet-881	317	8	)	)	PUNCT
admet-881	317	9	91	91	NUM
admet-881	317	10	-	-	SYM
admet-881	317	11	97	97	NUM
admet-881	317	12	.	.	PUNCT
admet-881	318	1	[	[	X
admet-881	318	2	25	25	NUM
admet-881	318	3	]	]	X
admet-881	318	4	l.c	l.c	PROPN
admet-881	318	5	.	.	PROPN
admet-881	318	6	alskär	alskär	PROPN
admet-881	318	7	,	,	PUNCT
admet-881	318	8	c.j	c.j	PROPN
admet-881	318	9	.	.	PROPN
admet-881	318	10	porter	porter	PROPN
admet-881	318	11	,	,	PUNCT
admet-881	318	12	c.a	c.a	PROPN
admet-881	318	13	.	.	PROPN
admet-881	318	14	bergström	bergström	NOUN
admet-881	318	15	.	.	PUNCT
admet-881	319	1	tools	tool	NOUN
admet-881	319	2	for	for	ADP
admet-881	319	3	early	early	ADJ
admet-881	319	4	prediction	prediction	NOUN
admet-881	319	5	of	of	ADP
admet-881	319	6	drug	drug	NOUN
admet-881	319	7	loading	loading	NOUN
admet-881	319	8	in	in	ADP
admet-881	319	9	lipid	lipid	NOUN
admet-881	319	10	-	-	PUNCT
admet-881	319	11	based	base	VERB
admet-881	319	12	formulations	formulation	NOUN
admet-881	319	13	.	.	PUNCT
admet-881	320	1	molecular	molecular	ADJ
admet-881	320	2	pharmaceutics	pharmaceutic	NOUN
admet-881	320	3	13	13	NUM
admet-881	320	4	(	(	PUNCT
admet-881	320	5	2016	2016	NUM
admet-881	320	6	)	)	PUNCT
admet-881	320	7	251	251	NUM
admet-881	320	8	-	-	SYM
admet-881	320	9	261	261	NUM
admet-881	320	10	.	.	PUNCT
admet-881	321	1	[	[	X
admet-881	321	2	26	26	NUM
admet-881	321	3	]	]	X
admet-881	321	4	b.	b.	PROPN
admet-881	321	5	van	van	PROPN
admet-881	321	6	eerdenbrugh	eerdenbrugh	PROPN
admet-881	321	7	,	,	PUNCT
admet-881	321	8	g.	g.	PROPN
admet-881	321	9	van	van	PROPN
admet-881	321	10	den	den	PROPN
admet-881	321	11	mooter	mooter	NOUN
admet-881	321	12	,	,	PUNCT
admet-881	321	13	p.	p.	NOUN
admet-881	321	14	augustijns	augustijns	NOUN
admet-881	321	15	.	.	PUNCT
admet-881	322	1	top	top	ADJ
admet-881	322	2	-	-	PUNCT
admet-881	322	3	down	down	ADP
admet-881	322	4	production	production	NOUN
admet-881	322	5	of	of	ADP
admet-881	322	6	drug	drug	NOUN
admet-881	322	7	nanocrystals	nanocrystal	NOUN
admet-881	322	8	:	:	PUNCT
admet-881	322	9	nanosuspension	nanosuspension	NOUN
admet-881	322	10	stabilization	stabilization	NOUN
admet-881	322	11	,	,	PUNCT
admet-881	322	12	miniaturization	miniaturization	NOUN
admet-881	322	13	and	and	CCONJ
admet-881	322	14	transformation	transformation	NOUN
admet-881	322	15	into	into	ADP
admet-881	322	16	solid	solid	ADJ
admet-881	322	17	products	product	NOUN
admet-881	322	18	.	.	PUNCT
admet-881	323	1	international	international	ADJ
admet-881	323	2	journal	journal	PROPN
admet-881	323	3	of	of	ADP
admet-881	323	4	pharmaceutics	pharmaceutic	NOUN
admet-881	323	5	364	364	NUM
admet-881	323	6	(	(	PUNCT
admet-881	323	7	2008	2008	NUM
admet-881	323	8	)	)	PUNCT
admet-881	323	9	64	64	NUM
admet-881	323	10	-	-	SYM
admet-881	323	11	75	75	NUM
admet-881	323	12	.	.	PUNCT
admet-881	324	1	[	[	X
admet-881	324	2	27	27	NUM
admet-881	324	3	]	]	X
admet-881	324	4	e.r	e.r	PROPN
admet-881	324	5	.	.	PROPN
admet-881	324	6	cooper	cooper	PROPN
admet-881	324	7	.	.	PUNCT
admet-881	325	1	nanoparticles	nanoparticle	NOUN
admet-881	325	2	:	:	PUNCT
admet-881	325	3	a	a	DET
admet-881	325	4	personal	personal	ADJ
admet-881	325	5	experience	experience	NOUN
admet-881	325	6	for	for	ADP
admet-881	325	7	formulating	formulate	VERB
admet-881	325	8	poorly	poorly	ADV
admet-881	325	9	water	water	NOUN
admet-881	325	10	soluble	soluble	ADJ
admet-881	325	11	drugs	drug	NOUN
admet-881	325	12	.	.	PUNCT
admet-881	326	1	journal	journal	PROPN
admet-881	326	2	of	of	ADP
admet-881	326	3	controlled	control	VERB
admet-881	326	4	release	release	NOUN
admet-881	326	5	141	141	NUM
admet-881	326	6	(	(	PUNCT
admet-881	326	7	2010	2010	NUM
admet-881	326	8	)	)	PUNCT
admet-881	326	9	300	300	NUM
admet-881	326	10	-	-	SYM
admet-881	326	11	302	302	NUM
admet-881	326	12	.	.	PUNCT
admet-881	327	1	[	[	X
admet-881	327	2	28	28	NUM
admet-881	327	3	]	]	X
admet-881	327	4	k.	k.	PROPN
admet-881	327	5	sigfridsson	sigfridsson	PROPN
admet-881	327	6	,	,	PUNCT
admet-881	327	7	a.j	a.j	PROPN
admet-881	327	8	.	.	PROPN
admet-881	327	9	lundqvist	lundqvist	PROPN
admet-881	327	10	,	,	PUNCT
admet-881	327	11	m.	m.	NOUN
admet-881	327	12	strimfors	strimfor	NOUN
admet-881	327	13	.	.	PUNCT
admet-881	328	1	particle	particle	NOUN
admet-881	328	2	size	size	NOUN
admet-881	328	3	reduction	reduction	NOUN
admet-881	328	4	for	for	ADP
admet-881	328	5	improvement	improvement	NOUN
admet-881	328	6	of	of	ADP
admet-881	328	7	oral	oral	ADJ
admet-881	328	8	absorption	absorption	NOUN
admet-881	328	9	of	of	ADP
admet-881	328	10	the	the	DET
admet-881	328	11	poorly	poorly	ADV
admet-881	328	12	soluble	soluble	ADJ
admet-881	328	13	drug	drug	NOUN
admet-881	328	14	ug558	ug558	VERB
admet-881	328	15	in	in	ADP
admet-881	328	16	rats	rat	NOUN
admet-881	328	17	during	during	ADP
admet-881	328	18	early	early	ADJ
admet-881	328	19	development	development	NOUN
admet-881	328	20	.	.	PUNCT
admet-881	329	1	drug	drug	NOUN
admet-881	329	2	development	development	NOUN
admet-881	329	3	and	and	CCONJ
admet-881	329	4	industrial	industrial	ADJ
admet-881	329	5	pharmacy	pharmacy	NOUN
admet-881	329	6	35	35	NUM
admet-881	329	7	(	(	PUNCT
admet-881	329	8	2009	2009	NUM
admet-881	329	9	)	)	PUNCT
admet-881	329	10	1479	1479	NUM
admet-881	329	11	-	-	SYM
admet-881	329	12	1486	1486	NUM
admet-881	329	13	.	.	PUNCT
admet-881	330	1	[	[	X
admet-881	330	2	29	29	NUM
admet-881	330	3	]	]	PUNCT
admet-881	330	4	k.	k.	PROPN
admet-881	330	5	sugano	sugano	PROPN
admet-881	330	6	.	.	PUNCT
admet-881	331	1	possible	possible	ADJ
admet-881	331	2	reduction	reduction	NOUN
admet-881	331	3	of	of	ADP
admet-881	331	4	effective	effective	ADJ
admet-881	331	5	thickness	thickness	NOUN
admet-881	331	6	of	of	ADP
admet-881	331	7	intestinal	intestinal	ADJ
admet-881	331	8	unstirred	unstirred	ADJ
admet-881	331	9	water	water	NOUN
admet-881	331	10	layer	layer	NOUN
admet-881	331	11	by	by	ADP
admet-881	331	12	particle	particle	NOUN
admet-881	331	13	drifting	drift	VERB
admet-881	331	14	effect	effect	NOUN
admet-881	331	15	.	.	PUNCT
admet-881	332	1	int	int	NOUN
admet-881	332	2	j	j	PROPN
admet-881	332	3	pharm	pharm	NOUN
admet-881	332	4	387	387	NUM
admet-881	332	5	(	(	PUNCT
admet-881	332	6	2010	2010	NUM
admet-881	332	7	)	)	PUNCT
admet-881	332	8	103	103	NUM
admet-881	332	9	-	-	SYM
admet-881	332	10	109	109	NUM
admet-881	332	11	.	.	PUNCT
admet-881	333	1	[	[	X
admet-881	333	2	30	30	NUM
admet-881	333	3	]	]	X
admet-881	333	4	s.b	s.b	PROPN
admet-881	333	5	.	.	PROPN
admet-881	333	6	murdande	murdande	PROPN
admet-881	333	7	,	,	PUNCT
admet-881	333	8	d.a	d.a	PROPN
admet-881	333	9	.	.	PROPN
admet-881	333	10	shah	shah	PROPN
admet-881	333	11	,	,	PUNCT
admet-881	333	12	r.h	r.h	PROPN
admet-881	333	13	.	.	PROPN
admet-881	333	14	dave	dave	PROPN
admet-881	333	15	.	.	PUNCT
admet-881	334	1	impact	impact	NOUN
admet-881	334	2	of	of	ADP
admet-881	334	3	nanosizing	nanosizing	NOUN
admet-881	334	4	on	on	ADP
admet-881	334	5	solubility	solubility	NOUN
admet-881	334	6	and	and	CCONJ
admet-881	334	7	dissolution	dissolution	NOUN
admet-881	334	8	rate	rate	NOUN
admet-881	334	9	of	of	ADP
admet-881	334	10	poorly	poorly	ADV
admet-881	334	11	soluble	soluble	ADJ
admet-881	334	12	pharmaceuticals	pharmaceutical	NOUN
admet-881	334	13	.	.	PUNCT
admet-881	335	1	journal	journal	NOUN
admet-881	335	2	of	of	ADP
admet-881	335	3	pharmaceutical	pharmaceutical	PROPN
admet-881	335	4	sciences	science	NOUN
admet-881	335	5	104	104	NUM
admet-881	335	6	(	(	PUNCT
admet-881	335	7	2015	2015	NUM
admet-881	335	8	)	)	PUNCT
admet-881	335	9	2094	2094	NUM
admet-881	335	10	-	-	SYM
admet-881	335	11	2102	2102	NUM
admet-881	335	12	.	.	PUNCT
admet-881	336	1	[	[	X
admet-881	336	2	31	31	NUM
admet-881	336	3	]	]	X
admet-881	336	4	f.	f.	PROPN
admet-881	336	5	kesisoglou	kesisoglou	PROPN
admet-881	336	6	,	,	PUNCT
admet-881	336	7	m.	m.	PROPN
admet-881	336	8	wang	wang	PROPN
admet-881	336	9	,	,	PUNCT
admet-881	336	10	k.	k.	PROPN
admet-881	336	11	galipeau	galipeau	PROPN
admet-881	336	12	,	,	PUNCT
admet-881	336	13	p.	p.	PROPN
admet-881	336	14	harmon	harmon	PROPN
admet-881	336	15	,	,	PUNCT
admet-881	336	16	g.	g.	PROPN
admet-881	336	17	okoh	okoh	PROPN
admet-881	336	18	,	,	PUNCT
admet-881	336	19	w.	w.	PROPN
admet-881	336	20	xu	xu	PROPN
admet-881	336	21	.	.	PUNCT
admet-881	337	1	effect	effect	NOUN
admet-881	337	2	of	of	ADP
admet-881	337	3	amorphous	amorphous	ADJ
admet-881	337	4	nanoparticle	nanoparticle	NOUN
admet-881	337	5	size	size	NOUN
admet-881	337	6	on	on	ADP
admet-881	337	7	bioavailability	bioavailability	NOUN
admet-881	337	8	of	of	ADP
admet-881	337	9	anacetrapib	anacetrapib	ADJ
admet-881	337	10	in	in	ADP
admet-881	337	11	dogs	dog	NOUN
admet-881	337	12	.	.	PUNCT
admet-881	338	1	journal	journal	NOUN
admet-881	338	2	of	of	ADP
admet-881	338	3	pharmaceutical	pharmaceutical	PROPN
admet-881	338	4	sciences	science	NOUN
admet-881	338	5	108	108	NUM
admet-881	338	6	(	(	PUNCT
admet-881	338	7	2019	2019	NUM
admet-881	338	8	)	)	PUNCT
admet-881	338	9	29172925	29172925	NUM
admet-881	338	10	.	.	PUNCT
admet-881	339	1	[	[	X
admet-881	339	2	32	32	NUM
admet-881	339	3	]	]	PUNCT
admet-881	339	4	d.	d.	PROPN
admet-881	339	5	babadi	babadi	PROPN
admet-881	339	6	,	,	PUNCT
admet-881	339	7	s.	s.	PROPN
admet-881	339	8	dadashzadeh	dadashzadeh	PROPN
admet-881	339	9	,	,	PUNCT
admet-881	339	10	m.	m.	PROPN
admet-881	339	11	osouli	osouli	PROPN
admet-881	339	12	,	,	PUNCT
admet-881	339	13	m.s	m.s	PROPN
admet-881	339	14	.	.	PROPN
admet-881	339	15	daryabari	daryabari	PROPN
admet-881	339	16	,	,	PUNCT
admet-881	339	17	a.	a.	PROPN
admet-881	339	18	haeri	haeri	PROPN
admet-881	339	19	.	.	PUNCT
admet-881	340	1	nanoformulation	nanoformulation	NOUN
admet-881	340	2	strategies	strategy	NOUN
admet-881	340	3	for	for	ADP
admet-881	340	4	improving	improve	VERB
admet-881	340	5	intestinal	intestinal	ADJ
admet-881	340	6	permeability	permeability	NOUN
admet-881	340	7	of	of	ADP
admet-881	340	8	drugs	drug	NOUN
admet-881	340	9	:	:	PUNCT
admet-881	340	10	a	a	DET
admet-881	340	11	more	more	ADV
admet-881	340	12	precise	precise	ADJ
admet-881	340	13	look	look	NOUN
admet-881	340	14	at	at	ADP
admet-881	340	15	permeability	permeability	NOUN
admet-881	340	16	assessment	assessment	NOUN
admet-881	340	17	methods	method	NOUN
admet-881	340	18	and	and	CCONJ
admet-881	340	19	pharmacokinetic	pharmacokinetic	ADJ
admet-881	340	20	properties	property	NOUN
admet-881	340	21	changes	change	NOUN
admet-881	340	22	.	.	PUNCT
admet-881	341	1	journal	journal	NOUN
admet-881	341	2	of	of	ADP
admet-881	341	3	controlled	control	VERB
admet-881	341	4	release	release	NOUN
admet-881	341	5	(	(	PUNCT
admet-881	341	6	2020	2020	NUM
admet-881	341	7	)	)	PUNCT
admet-881	341	8	.	.	PUNCT
admet-881	342	1	[	[	X
admet-881	342	2	33	33	NUM
admet-881	342	3	]	]	PUNCT
admet-881	342	4	s.	s.	PROPN
admet-881	342	5	colombo	colombo	PROPN
admet-881	342	6	,	,	PUNCT
admet-881	342	7	m.	m.	NOUN
admet-881	342	8	brisander	brisander	NOUN
admet-881	342	9	,	,	PUNCT
admet-881	342	10	j.	j.	PROPN
admet-881	342	11	haglöf	haglöf	PROPN
admet-881	342	12	,	,	PUNCT
admet-881	342	13	p.	p.	PROPN
admet-881	342	14	sjövall	sjövall	PROPN
admet-881	342	15	,	,	PUNCT
admet-881	342	16	p.	p.	PROPN
admet-881	342	17	andersson	andersson	PROPN
admet-881	342	18	,	,	PUNCT
admet-881	342	19	j.	j.	PROPN
admet-881	342	20	østergaard	østergaard	PROPN
admet-881	342	21	,	,	PUNCT
admet-881	342	22	m.	m.	NOUN
admet-881	342	23	malmsten	malmsten	PROPN
admet-881	342	24	.	.	PUNCT
admet-881	343	1	matrix	matrix	NOUN
admet-881	343	2	effects	effect	NOUN
admet-881	343	3	in	in	ADP
admet-881	343	4	nilotinib	nilotinib	NOUN
admet-881	343	5	formulations	formulation	NOUN
admet-881	343	6	with	with	ADP
admet-881	343	7	ph	ph	ADJ
admet-881	343	8	-	-	PUNCT
admet-881	343	9	responsive	responsive	ADJ
admet-881	343	10	polymer	polymer	NOUN
admet-881	343	11	produced	produce	VERB
admet-881	343	12	by	by	ADP
admet-881	343	13	carbon	carbon	NOUN
admet-881	343	14	dioxide	dioxide	NOUN
admet-881	343	15	-	-	PUNCT
admet-881	343	16	mediated	mediate	VERB
admet-881	343	17	precipitation	precipitation	NOUN
admet-881	343	18	.	.	PUNCT
admet-881	344	1	international	international	ADJ
admet-881	344	2	journal	journal	PROPN
admet-881	344	3	of	of	ADP
admet-881	344	4	pharmaceutics	pharmaceutic	NOUN
admet-881	344	5	494	494	NUM
admet-881	344	6	(	(	PUNCT
admet-881	344	7	2015	2015	NUM
admet-881	344	8	)	)	PUNCT
admet-881	344	9	205	205	NUM
admet-881	344	10	-	-	SYM
admet-881	344	11	217	217	NUM
admet-881	344	12	.	.	PUNCT
admet-881	345	1	[	[	X
admet-881	345	2	34	34	NUM
admet-881	345	3	]	]	X
admet-881	345	4	j.-i	j.-i	PROPN
admet-881	345	5	.	.	PUNCT
admet-881	345	6	jinno	jinno	PROPN
admet-881	345	7	,	,	PUNCT
admet-881	345	8	n.	n.	PROPN
admet-881	345	9	kamada	kamada	PROPN
admet-881	345	10	,	,	PUNCT
admet-881	345	11	m.	m.	PROPN
admet-881	345	12	miyake	miyake	PROPN
admet-881	345	13	,	,	PUNCT
admet-881	345	14	k.	k.	PROPN
admet-881	345	15	yamada	yamada	PROPN
admet-881	345	16	,	,	PUNCT
admet-881	345	17	t.	t.	PROPN
admet-881	345	18	mukai	mukai	PROPN
admet-881	345	19	,	,	PUNCT
admet-881	345	20	m.	m.	NOUN
admet-881	345	21	odomi	odomi	PROPN
admet-881	345	22	,	,	PUNCT
admet-881	345	23	h.	h.	PROPN
admet-881	345	24	toguchi	toguchi	PROPN
admet-881	345	25	,	,	PUNCT
admet-881	345	26	g.g	g.g	PROPN
admet-881	345	27	.	.	PROPN
admet-881	345	28	liversidge	liversidge	PROPN
admet-881	345	29	,	,	PUNCT
admet-881	345	30	k.	k.	PROPN
admet-881	345	31	higaki	higaki	PROPN
admet-881	345	32	,	,	PUNCT
admet-881	345	33	t.	t.	PROPN
admet-881	345	34	kimura	kimura	NOUN
admet-881	345	35	.	.	PUNCT
admet-881	346	1	effect	effect	NOUN
admet-881	346	2	of	of	ADP
admet-881	346	3	particle	particle	NOUN
admet-881	346	4	size	size	NOUN
admet-881	346	5	reduction	reduction	NOUN
admet-881	346	6	on	on	ADP
admet-881	346	7	dissolution	dissolution	NOUN
admet-881	346	8	and	and	CCONJ
admet-881	346	9	oral	oral	ADJ
admet-881	346	10	absorption	absorption	NOUN
admet-881	346	11	of	of	ADP
admet-881	346	12	a	a	DET
admet-881	346	13	poorly	poorly	ADV
admet-881	346	14	water	water	NOUN
admet-881	346	15	-	-	PUNCT
admet-881	346	16	soluble	soluble	ADJ
admet-881	346	17	drug	drug	NOUN
admet-881	346	18	,	,	PUNCT
admet-881	346	19	cilostazol	cilostazol	ADJ
admet-881	346	20	,	,	PUNCT
admet-881	346	21	in	in	ADP
admet-881	346	22	beagle	beagle	NOUN
admet-881	346	23	dogs	dog	NOUN
admet-881	346	24	.	.	PUNCT
admet-881	347	1	journal	journal	NOUN
admet-881	347	2	of	of	ADP
admet-881	347	3	controlled	control	VERB
admet-881	347	4	release	release	NOUN
admet-881	347	5	111	111	NUM
admet-881	347	6	(	(	PUNCT
admet-881	347	7	2006	2006	NUM
admet-881	347	8	)	)	PUNCT
admet-881	347	9	56	56	NUM
admet-881	347	10	-	-	SYM
admet-881	347	11	64	64	NUM
admet-881	347	12	.	.	PUNCT
admet-881	348	1	[	[	X
admet-881	348	2	35	35	NUM
admet-881	348	3	]	]	X
admet-881	348	4	e.	e.	PROPN
admet-881	348	5	merisko	merisko	PROPN
admet-881	348	6	-	-	PUNCT
admet-881	348	7	liversidge	liversidge	VERB
admet-881	348	8	,	,	PUNCT
admet-881	348	9	g.g	g.g	PROPN
admet-881	348	10	.	.	PROPN
admet-881	348	11	liversidge	liversidge	PROPN
admet-881	348	12	,	,	PUNCT
admet-881	348	13	e.r	e.r	PROPN
admet-881	348	14	.	.	PROPN
admet-881	348	15	cooper	cooper	PROPN
admet-881	348	16	.	.	PUNCT
admet-881	349	1	nanosizing	nanosizing	NOUN
admet-881	349	2	:	:	PUNCT
admet-881	349	3	a	a	DET
admet-881	349	4	formulation	formulation	NOUN
admet-881	349	5	approach	approach	NOUN
admet-881	349	6	for	for	ADP
admet-881	349	7	poorlywater	poorlywater	NOUN
admet-881	349	8	-	-	PUNCT
admet-881	349	9	soluble	soluble	ADJ
admet-881	349	10	compounds	compound	NOUN
admet-881	349	11	.	.	PUNCT
admet-881	350	1	european	european	ADJ
admet-881	350	2	journal	journal	PROPN
admet-881	350	3	of	of	ADP
admet-881	350	4	pharmaceutical	pharmaceutical	PROPN
admet-881	350	5	sciences	science	NOUN
admet-881	350	6	18	18	NUM
admet-881	350	7	(	(	PUNCT
admet-881	350	8	2003	2003	NUM
admet-881	350	9	)	)	PUNCT
admet-881	350	10	113	113	NUM
admet-881	350	11	-	-	SYM
admet-881	350	12	120	120	NUM
admet-881	350	13	.	.	PUNCT
admet-881	351	1	[	[	X
admet-881	351	2	36	36	NUM
admet-881	351	3	]	]	X
admet-881	351	4	r.	r.	PROPN
admet-881	351	5	müller	müller	PROPN
admet-881	351	6	,	,	PUNCT
admet-881	351	7	c.	c.	PROPN
admet-881	351	8	jacobs	jacobs	PROPN
admet-881	351	9	,	,	PUNCT
admet-881	351	10	o.	o.	PROPN
admet-881	351	11	kayser	kayser	PROPN
admet-881	351	12	.	.	PUNCT
admet-881	352	1	nanosuspensions	nanosuspension	NOUN
admet-881	352	2	as	as	ADP
admet-881	352	3	particulate	particulate	NOUN
admet-881	352	4	drug	drug	NOUN
admet-881	352	5	formulations	formulation	NOUN
admet-881	352	6	in	in	ADP
admet-881	352	7	therapy	therapy	NOUN
admet-881	352	8	:	:	PUNCT
admet-881	352	9	rationale	rationale	NOUN
admet-881	352	10	for	for	ADP
admet-881	352	11	development	development	NOUN
admet-881	352	12	and	and	CCONJ
admet-881	352	13	what	what	PRON
admet-881	352	14	we	we	PRON
admet-881	352	15	can	can	AUX
admet-881	352	16	expect	expect	VERB
admet-881	352	17	for	for	ADP
admet-881	352	18	the	the	DET
admet-881	352	19	future	future	NOUN
admet-881	352	20	.	.	PUNCT
admet-881	353	1	adv	adv	PROPN
admet-881	353	2	drug	drug	PROPN
admet-881	353	3	deliv	deliv	NOUN
admet-881	353	4	rev	rev	VERB
admet-881	353	5	47	47	NUM
admet-881	353	6	(	(	PUNCT
admet-881	353	7	2001	2001	NUM
admet-881	353	8	)	)	PUNCT
admet-881	353	9	3	3	NUM
admet-881	353	10	-	-	SYM
admet-881	353	11	19	19	NUM
admet-881	353	12	.	.	PUNCT
admet-881	354	1	[	[	X
admet-881	354	2	37	37	NUM
admet-881	354	3	]	]	X
admet-881	354	4	b.	b.	PROPN
admet-881	354	5	hens	hens	PROPN
admet-881	354	6	,	,	PUNCT
admet-881	354	7	j.	j.	PROPN
admet-881	354	8	brouwers	brouwers	PROPN
admet-881	354	9	,	,	PUNCT
admet-881	354	10	m.	m.	NOUN
admet-881	354	11	corsetti	corsetti	PROPN
admet-881	354	12	,	,	PUNCT
admet-881	354	13	p.	p.	NOUN
admet-881	354	14	augustijns	augustijns	NOUN
admet-881	354	15	.	.	PUNCT
admet-881	355	1	gastrointestinal	gastrointestinal	ADJ
admet-881	355	2	behavior	behavior	NOUN
admet-881	355	3	of	of	ADP
admet-881	355	4	nano	nano	NOUN
admet-881	355	5	-	-	PUNCT
admet-881	355	6	and	and	CCONJ
admet-881	355	7	microsized	microsize	VERB
admet-881	355	8	fenofibrate	fenofibrate	NOUN
admet-881	355	9	:	:	PUNCT
admet-881	355	10	in	in	ADP
admet-881	355	11	vivo	vivo	ADJ
admet-881	355	12	evaluation	evaluation	NOUN
admet-881	355	13	in	in	ADP
admet-881	355	14	man	man	NOUN
admet-881	355	15	and	and	CCONJ
admet-881	355	16	in	in	ADP
admet-881	355	17	vitro	vitro	X
admet-881	355	18	simulation	simulation	NOUN
admet-881	355	19	by	by	ADP
admet-881	355	20	assessment	assessment	NOUN
admet-881	355	21	of	of	ADP
admet-881	355	22	the	the	DET
admet-881	355	23	permeation	permeation	NOUN
admet-881	355	24	potential	potential	NOUN
admet-881	355	25	.	.	PUNCT
admet-881	356	1	european	european	ADJ
admet-881	356	2	journal	journal	PROPN
admet-881	356	3	of	of	ADP
admet-881	356	4	pharmaceutical	pharmaceutical	PROPN
admet-881	356	5	sciences	science	NOUN
admet-881	356	6	77	77	NUM
admet-881	356	7	(	(	PUNCT
admet-881	356	8	2015	2015	NUM
admet-881	356	9	)	)	PUNCT
admet-881	356	10	40	40	NUM
admet-881	356	11	-	-	SYM
admet-881	356	12	47	47	NUM
admet-881	356	13	.	.	PUNCT
admet-881	357	1	[	[	X
admet-881	357	2	38	38	NUM
admet-881	357	3	]	]	PUNCT
admet-881	357	4	k.	k.	PROPN
admet-881	357	5	sugano	sugano	PROPN
admet-881	357	6	.	.	PUNCT
admet-881	358	1	aqueous	aqueous	ADJ
admet-881	358	2	boundary	boundary	ADJ
admet-881	358	3	layers	layer	NOUN
admet-881	358	4	related	relate	VERB
admet-881	358	5	to	to	ADP
admet-881	358	6	oral	oral	ADJ
admet-881	358	7	absorption	absorption	NOUN
admet-881	358	8	of	of	ADP
admet-881	358	9	a	a	DET
admet-881	358	10	drug	drug	NOUN
admet-881	358	11	:	:	PUNCT
admet-881	358	12	from	from	ADP
admet-881	358	13	dissolution	dissolution	NOUN
admet-881	358	14	of	of	ADP
admet-881	358	15	a	a	DET
admet-881	358	16	drug	drug	NOUN
admet-881	358	17	to	to	ADP
admet-881	358	18	carrier	carrier	NOUN
admet-881	358	19	mediated	mediate	VERB
admet-881	358	20	transport	transport	NOUN
admet-881	358	21	and	and	CCONJ
admet-881	358	22	intestinal	intestinal	ADJ
admet-881	358	23	wall	wall	NOUN
admet-881	358	24	metabolism	metabolism	NOUN
admet-881	358	25	.	.	PUNCT
admet-881	359	1	molecular	molecular	ADJ
admet-881	359	2	pharmaceutics	pharmaceutic	NOUN
admet-881	359	3	7	7	NUM
admet-881	359	4	(	(	PUNCT
admet-881	359	5	2010	2010	NUM
admet-881	359	6	)	)	PUNCT
admet-881	359	7	1362	1362	NUM
admet-881	359	8	-	-	SYM
admet-881	359	9	1373	1373	NUM
admet-881	359	10	.	.	PUNCT
admet-881	360	1	[	[	X
admet-881	360	2	39	39	NUM
admet-881	360	3	]	]	X
admet-881	360	4	g.e	g.e	PROPN
admet-881	360	5	.	.	PROPN
admet-881	360	6	amidon	amidon	PROPN
admet-881	360	7	,	,	PUNCT
admet-881	360	8	w.i	w.i	PROPN
admet-881	360	9	.	.	PROPN
admet-881	360	10	higuchi	higuchi	PROPN
admet-881	360	11	,	,	PUNCT
admet-881	360	12	n.f	n.f	PROPN
admet-881	360	13	.	.	PROPN
admet-881	360	14	ho	ho	PROPN
admet-881	360	15	.	.	PROPN
admet-881	360	16	theoretical	theoretical	ADJ
admet-881	360	17	and	and	CCONJ
admet-881	360	18	experimental	experimental	ADJ
admet-881	360	19	studies	study	NOUN
admet-881	360	20	of	of	ADP
admet-881	360	21	transport	transport	NOUN
admet-881	360	22	of	of	ADP
admet-881	360	23	micelle‐	micelle‐	NOUN
admet-881	360	24	solubilized	solubilize	VERB
admet-881	360	25	solutes	solute	NOUN
admet-881	360	26	.	.	PUNCT
admet-881	361	1	j	j	PROPN
admet-881	361	2	pharm	pharm	PROPN
admet-881	361	3	sci	sci	PROPN
admet-881	361	4	71	71	NUM
admet-881	361	5	(	(	PUNCT
admet-881	361	6	1982	1982	NUM
admet-881	361	7	)	)	PUNCT
admet-881	361	8	77	77	NUM
admet-881	361	9	-	-	SYM
admet-881	361	10	84	84	NUM
admet-881	361	11	.	.	PUNCT
admet-881	362	1	[	[	X
admet-881	362	2	40	40	NUM
admet-881	362	3	]	]	X
admet-881	362	4	s.k	s.k	PROPN
admet-881	362	5	.	.	PROPN
admet-881	362	6	lai	lai	PROPN
admet-881	362	7	,	,	PUNCT
admet-881	362	8	d.e	d.e	PROPN
admet-881	362	9	.	.	PROPN
admet-881	362	10	o'hanlon	o'hanlon	PROPN
admet-881	362	11	,	,	PUNCT
admet-881	362	12	s.	s.	PROPN
admet-881	362	13	harrold	harrold	PROPN
admet-881	362	14	,	,	PUNCT
admet-881	362	15	s.t	s.t	PROPN
admet-881	362	16	.	.	PROPN
admet-881	362	17	man	man	PROPN
admet-881	362	18	,	,	PUNCT
admet-881	362	19	y.-y	y.-y	PROPN
admet-881	362	20	.	.	PUNCT
admet-881	363	1	wang	wang	PROPN
admet-881	363	2	,	,	PUNCT
admet-881	363	3	r.	r.	PROPN
admet-881	363	4	cone	cone	PROPN
admet-881	363	5	,	,	PUNCT
admet-881	363	6	j.	j.	PROPN
admet-881	363	7	hanes	hanes	PROPN
admet-881	363	8	.	.	PUNCT
admet-881	364	1	rapid	rapid	ADJ
admet-881	364	2	transport	transport	NOUN
admet-881	364	3	of	of	ADP
admet-881	364	4	large	large	ADJ
admet-881	364	5	polymeric	polymeric	ADJ
admet-881	364	6	nanoparticles	nanoparticle	NOUN
admet-881	364	7	in	in	ADP
admet-881	364	8	fresh	fresh	ADJ
admet-881	364	9	undiluted	undiluted	ADJ
admet-881	364	10	human	human	ADJ
admet-881	364	11	mucus	mucus	NOUN
admet-881	364	12	.	.	PUNCT
admet-881	365	1	proceedings	proceeding	NOUN
admet-881	365	2	of	of	ADP
admet-881	365	3	the	the	DET
admet-881	365	4	national	national	PROPN
admet-881	365	5	academy	academy	PROPN
admet-881	365	6	of	of	ADP
admet-881	365	7	sciences	sciences	PROPN
admet-881	365	8	104	104	NUM
admet-881	365	9	(	(	PUNCT
admet-881	365	10	2007	2007	NUM
admet-881	365	11	)	)	PUNCT
admet-881	365	12	1482	1482	NUM
admet-881	365	13	-	-	SYM
admet-881	365	14	1487	1487	NUM
admet-881	365	15	.	.	PUNCT
admet-881	366	1	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	PROPN
admet-881	366	2	h.	h.	PROPN
admet-881	366	3	lennernäs	lennernäs	PROPN
admet-881	366	4	et	et	PROPN
admet-881	366	5	al	al	PROPN
admet-881	366	6	.	.	PROPN
admet-881	366	7	admet	admet	PROPN
admet-881	366	8	&	&	CCONJ
admet-881	366	9	dmpk	dmpk	PROPN
admet-881	366	10	8(4	8(4	NOUN
admet-881	366	11	)	)	PUNCT
admet-881	366	12	(	(	PUNCT
admet-881	366	13	2020	2020	NUM
admet-881	366	14	)	)	PUNCT
admet-881	366	15	375	375	NUM
admet-881	366	16	-	-	SYM
admet-881	366	17	390	390	NUM
admet-881	366	18	388	388	NUM
admet-881	366	19	[	[	X
admet-881	366	20	41	41	NUM
admet-881	366	21	]	]	PUNCT
admet-881	366	22	k.	k.	PROPN
admet-881	366	23	netsomboon	netsomboon	PROPN
admet-881	366	24	,	,	PUNCT
admet-881	366	25	a.	a.	PROPN
admet-881	366	26	bernkop	bernkop	PROPN
admet-881	366	27	-	-	PUNCT
admet-881	366	28	schnürch	schnürch	NOUN
admet-881	366	29	.	.	PUNCT
admet-881	367	1	mucoadhesive	mucoadhesive	ADJ
admet-881	367	2	vs.	vs.	ADP
admet-881	367	3	mucopenetrating	mucopenetrate	VERB
admet-881	367	4	particulate	particulate	NOUN
admet-881	367	5	drug	drug	NOUN
admet-881	367	6	delivery	delivery	NOUN
admet-881	367	7	.	.	PUNCT
admet-881	368	1	european	european	ADJ
admet-881	368	2	journal	journal	PROPN
admet-881	368	3	of	of	ADP
admet-881	368	4	pharmaceutics	pharmaceutic	NOUN
admet-881	368	5	and	and	CCONJ
admet-881	368	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	368	7	98	98	NUM
admet-881	368	8	(	(	PUNCT
admet-881	368	9	2016	2016	NUM
admet-881	368	10	)	)	PUNCT
admet-881	368	11	76	76	NUM
admet-881	368	12	-	-	SYM
admet-881	368	13	89	89	NUM
admet-881	368	14	.	.	PUNCT
admet-881	369	1	[	[	X
admet-881	369	2	42	42	NUM
admet-881	369	3	]	]	PUNCT
admet-881	369	4	j.	j.	PROPN
admet-881	369	5	leal	leal	PROPN
admet-881	369	6	,	,	PUNCT
admet-881	369	7	h.d	h.d	PROPN
admet-881	369	8	.	.	PROPN
admet-881	369	9	smyth	smyth	PROPN
admet-881	369	10	,	,	PUNCT
admet-881	369	11	d.	d.	PROPN
admet-881	369	12	ghosh	ghosh	PROPN
admet-881	369	13	.	.	PUNCT
admet-881	370	1	physicochemical	physicochemical	ADJ
admet-881	370	2	properties	property	NOUN
admet-881	370	3	of	of	ADP
admet-881	370	4	mucus	mucus	NOUN
admet-881	370	5	and	and	CCONJ
admet-881	370	6	their	their	PRON
admet-881	370	7	impact	impact	NOUN
admet-881	370	8	on	on	ADP
admet-881	370	9	transmucosal	transmucosal	ADJ
admet-881	370	10	drug	drug	NOUN
admet-881	370	11	delivery	delivery	NOUN
admet-881	370	12	.	.	PUNCT
admet-881	371	1	international	international	ADJ
admet-881	371	2	journal	journal	PROPN
admet-881	371	3	of	of	ADP
admet-881	371	4	pharmaceutics	pharmaceutic	NOUN
admet-881	371	5	532	532	NUM
admet-881	371	6	(	(	PUNCT
admet-881	371	7	2017	2017	NUM
admet-881	371	8	)	)	PUNCT
admet-881	371	9	555	555	NUM
admet-881	371	10	-	-	SYM
admet-881	371	11	572	572	NUM
admet-881	371	12	.	.	PUNCT
admet-881	372	1	[	[	X
admet-881	372	2	43	43	NUM
admet-881	372	3	]	]	X
admet-881	372	4	m.d	m.d	PROPN
admet-881	372	5	.	.	PROPN
admet-881	372	6	levitt	levitt	PROPN
admet-881	372	7	,	,	PUNCT
admet-881	372	8	a.	a.	PROPN
admet-881	372	9	strocchi	strocchi	PROPN
admet-881	372	10	,	,	PUNCT
admet-881	372	11	d.g	d.g	PROPN
admet-881	372	12	.	.	PROPN
admet-881	372	13	levitt	levitt	PROPN
admet-881	372	14	.	.	PUNCT
admet-881	373	1	human	human	ADJ
admet-881	373	2	jejunal	jejunal	ADJ
admet-881	373	3	unstirred	unstirred	ADJ
admet-881	373	4	layer	layer	NOUN
admet-881	373	5	:	:	PUNCT
admet-881	373	6	evidence	evidence	NOUN
admet-881	373	7	for	for	ADP
admet-881	373	8	extremely	extremely	ADV
admet-881	373	9	efficient	efficient	ADJ
admet-881	373	10	luminal	luminal	ADJ
admet-881	373	11	stirring	stirring	NOUN
admet-881	373	12	.	.	PUNCT
admet-881	374	1	american	american	ADJ
admet-881	374	2	journal	journal	PROPN
admet-881	374	3	of	of	ADP
admet-881	374	4	physiology	physiology	NOUN
admet-881	374	5	-	-	PUNCT
admet-881	374	6	gastrointestinal	gastrointestinal	ADJ
admet-881	374	7	and	and	CCONJ
admet-881	374	8	liver	liver	NOUN
admet-881	374	9	physiology	physiology	NOUN
admet-881	374	10	262	262	NUM
admet-881	374	11	(	(	PUNCT
admet-881	374	12	1992	1992	NUM
admet-881	374	13	)	)	PUNCT
admet-881	374	14	g593	g593	PROPN
admet-881	374	15	-	-	PUNCT
admet-881	374	16	g596	g596	PROPN
admet-881	374	17	.	.	PUNCT
admet-881	375	1	[	[	X
admet-881	375	2	44	44	NUM
admet-881	375	3	]	]	X
admet-881	375	4	m.d	m.d	PROPN
admet-881	375	5	.	.	PROPN
admet-881	375	6	levitt	levitt	PROPN
admet-881	375	7	,	,	PUNCT
admet-881	375	8	j.k	j.k	PROPN
admet-881	375	9	.	.	PROPN
admet-881	375	10	furne	furne	PROPN
admet-881	375	11	.	.	PUNCT
admet-881	376	1	shaking	shake	VERB
admet-881	376	2	of	of	ADP
admet-881	376	3	the	the	DET
admet-881	376	4	intact	intact	ADJ
admet-881	376	5	angulation	angulation	NOUN
admet-881	376	6	diminish	diminish	VERB
admet-881	376	7	layer	layer	NOUN
admet-881	376	8	.	.	PUNCT
admet-881	377	1	gastroenterology	gastroenterology	NOUN
admet-881	377	2	103	103	NUM
admet-881	377	3	(	(	PUNCT
admet-881	377	4	1992	1992	NUM
admet-881	377	5	)	)	PUNCT
admet-881	377	6	1460	1460	NUM
admet-881	377	7	-	-	SYM
admet-881	377	8	1466	1466	NUM
admet-881	377	9	.	.	PUNCT
admet-881	378	1	[	[	X
admet-881	378	2	45	45	NUM
admet-881	378	3	]	]	X
admet-881	378	4	d.	d.	PROPN
admet-881	378	5	dahlgren	dahlgren	PROPN
admet-881	378	6	,	,	PUNCT
admet-881	378	7	m.	m.	NOUN
admet-881	378	8	sjöblom	sjöblom	PROPN
admet-881	378	9	,	,	PUNCT
admet-881	378	10	h.	h.	PROPN
admet-881	378	11	lennernäs	lennernäs	PROPN
admet-881	378	12	.	.	PUNCT
admet-881	379	1	intestinal	intestinal	ADJ
admet-881	379	2	absorption	absorption	NOUN
admet-881	379	3	-	-	PUNCT
admet-881	379	4	modifying	modify	VERB
admet-881	379	5	excipients	excipient	NOUN
admet-881	379	6	:	:	PUNCT
admet-881	379	7	a	a	DET
admet-881	379	8	current	current	ADJ
admet-881	379	9	update	update	NOUN
admet-881	379	10	on	on	ADP
admet-881	379	11	preclinical	preclinical	NOUN
admet-881	379	12	in	in	ADP
admet-881	379	13	vivo	vivo	NOUN
admet-881	379	14	evaluations	evaluation	NOUN
admet-881	379	15	.	.	PUNCT
admet-881	380	1	european	european	ADJ
admet-881	380	2	journal	journal	PROPN
admet-881	380	3	of	of	ADP
admet-881	380	4	pharmaceutics	pharmaceutic	NOUN
admet-881	380	5	and	and	CCONJ
admet-881	380	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	380	7	142	142	NUM
admet-881	380	8	(	(	PUNCT
admet-881	380	9	2019	2019	NUM
admet-881	380	10	)	)	PUNCT
admet-881	380	11	411	411	NUM
admet-881	380	12	-	-	SYM
admet-881	380	13	420	420	NUM
admet-881	380	14	.	.	PUNCT
admet-881	381	1	[	[	X
admet-881	381	2	46	46	NUM
admet-881	381	3	]	]	X
admet-881	381	4	u.	u.	PROPN
admet-881	381	5	fagerholm	fagerholm	PROPN
admet-881	381	6	,	,	PUNCT
admet-881	381	7	h.	h.	PROPN
admet-881	381	8	lennernäs	lennernäs	PROPN
admet-881	381	9	.	.	PUNCT
admet-881	382	1	experimental	experimental	ADJ
admet-881	382	2	estimation	estimation	NOUN
admet-881	382	3	of	of	ADP
admet-881	382	4	the	the	DET
admet-881	382	5	effective	effective	ADJ
admet-881	382	6	unstirred	unstirred	ADJ
admet-881	382	7	water	water	NOUN
admet-881	382	8	layer	layer	NOUN
admet-881	382	9	thickness	thickness	NOUN
admet-881	382	10	in	in	ADP
admet-881	382	11	the	the	DET
admet-881	382	12	human	human	ADJ
admet-881	382	13	jejunum	jejunum	NOUN
admet-881	382	14	,	,	PUNCT
admet-881	382	15	and	and	CCONJ
admet-881	382	16	its	its	PRON
admet-881	382	17	importance	importance	NOUN
admet-881	382	18	in	in	ADP
admet-881	382	19	oral	oral	ADJ
admet-881	382	20	drug	drug	NOUN
admet-881	382	21	absorption	absorption	NOUN
admet-881	382	22	.	.	PUNCT
admet-881	383	1	european	european	PROPN
admet-881	383	2	journal	journal	PROPN
admet-881	383	3	of	of	ADP
admet-881	383	4	pharmaceutical	pharmaceutical	PROPN
admet-881	383	5	sciences	science	NOUN
admet-881	383	6	3	3	NUM
admet-881	383	7	(	(	PUNCT
admet-881	383	8	1995	1995	NUM
admet-881	383	9	)	)	PUNCT
admet-881	383	10	247	247	NUM
admet-881	383	11	-	-	SYM
admet-881	383	12	253	253	NUM
admet-881	383	13	.	.	PUNCT
admet-881	384	1	[	[	X
admet-881	384	2	47	47	NUM
admet-881	384	3	]	]	X
admet-881	384	4	b.h	b.h	PROPN
admet-881	384	5	.	.	PROPN
admet-881	384	6	bajka	bajka	PROPN
admet-881	384	7	,	,	PUNCT
admet-881	384	8	n.m	n.m	PROPN
admet-881	384	9	.	.	PROPN
admet-881	384	10	rigby	rigby	PROPN
admet-881	384	11	,	,	PUNCT
admet-881	384	12	k.l	k.l	PROPN
admet-881	384	13	.	.	PROPN
admet-881	384	14	cross	cross	PROPN
admet-881	384	15	,	,	PUNCT
admet-881	384	16	a.	a.	NOUN
admet-881	384	17	macierzanka	macierzanka	PROPN
admet-881	384	18	,	,	PUNCT
admet-881	384	19	a.r	a.r	PROPN
admet-881	384	20	.	.	PROPN
admet-881	384	21	mackie	mackie	PROPN
admet-881	384	22	.	.	PUNCT
admet-881	385	1	the	the	DET
admet-881	385	2	influence	influence	NOUN
admet-881	385	3	of	of	ADP
admet-881	385	4	small	small	ADJ
admet-881	385	5	intestinal	intestinal	ADJ
admet-881	385	6	mucus	mucus	NOUN
admet-881	385	7	structure	structure	NOUN
admet-881	385	8	on	on	ADP
admet-881	385	9	particle	particle	NOUN
admet-881	385	10	transport	transport	NOUN
admet-881	385	11	ex	ex	X
admet-881	385	12	vivo	vivo	NOUN
admet-881	385	13	.	.	PUNCT
admet-881	386	1	colloids	colloid	NOUN
admet-881	386	2	and	and	CCONJ
admet-881	386	3	surfaces	surface	NOUN
admet-881	386	4	b	b	NUM
admet-881	386	5	:	:	PUNCT
admet-881	386	6	biointerfaces	biointerface	NOUN
admet-881	386	7	135	135	NUM
admet-881	386	8	(	(	PUNCT
admet-881	386	9	2015	2015	NUM
admet-881	386	10	)	)	PUNCT
admet-881	386	11	7380	7380	NUM
admet-881	386	12	.	.	PUNCT
admet-881	387	1	[	[	X
admet-881	387	2	48	48	NUM
admet-881	387	3	]	]	PUNCT
admet-881	387	4	a.	a.	NOUN
admet-881	387	5	einstein	einstein	PROPN
admet-881	387	6	.	.	PUNCT
admet-881	388	1	on	on	ADP
admet-881	388	2	the	the	DET
admet-881	388	3	motion	motion	NOUN
admet-881	388	4	of	of	ADP
admet-881	388	5	small	small	ADJ
admet-881	388	6	particles	particle	NOUN
admet-881	388	7	suspended	suspend	VERB
admet-881	388	8	in	in	ADP
admet-881	388	9	liquids	liquid	NOUN
admet-881	388	10	at	at	ADP
admet-881	388	11	rest	rest	NOUN
admet-881	388	12	required	require	VERB
admet-881	388	13	by	by	ADP
admet-881	388	14	the	the	DET
admet-881	388	15	molecularkinetic	molecularkinetic	ADJ
admet-881	388	16	theory	theory	NOUN
admet-881	388	17	of	of	ADP
admet-881	388	18	heat	heat	NOUN
admet-881	388	19	.	.	PUNCT
admet-881	389	1	annalen	annalen	PROPN
admet-881	389	2	der	der	PROPN
admet-881	389	3	physik	physik	PROPN
admet-881	389	4	17	17	NUM
admet-881	389	5	(	(	PUNCT
admet-881	389	6	1905	1905	NUM
admet-881	389	7	)	)	PUNCT
admet-881	389	8	549	549	NUM
admet-881	389	9	-	-	SYM
admet-881	389	10	560	560	NUM
admet-881	389	11	.	.	PUNCT
admet-881	390	1	[	[	X
admet-881	390	2	49	49	NUM
admet-881	390	3	]	]	X
admet-881	390	4	y.	y.	PROPN
admet-881	390	5	wang	wang	PROPN
admet-881	390	6	,	,	PUNCT
admet-881	390	7	j.g	j.g	PROPN
admet-881	390	8	.	.	PROPN
admet-881	390	9	brasseur	brasseur	PROPN
admet-881	390	10	.	.	PUNCT
admet-881	391	1	three	three	NUM
admet-881	391	2	-	-	PUNCT
admet-881	391	3	dimensional	dimensional	ADJ
admet-881	391	4	mechanisms	mechanism	NOUN
admet-881	391	5	of	of	ADP
admet-881	391	6	macro	macro	NOUN
admet-881	391	7	-	-	PUNCT
admet-881	391	8	to	to	ADP
admet-881	391	9	-	-	PUNCT
admet-881	391	10	micro	micro	NOUN
admet-881	391	11	-	-	NOUN
admet-881	391	12	scale	scale	ADJ
admet-881	391	13	transport	transport	NOUN
admet-881	391	14	and	and	CCONJ
admet-881	391	15	absorption	absorption	NOUN
admet-881	391	16	enhancement	enhancement	NOUN
admet-881	391	17	by	by	ADP
admet-881	391	18	gut	gut	NOUN
admet-881	391	19	villi	villi	NOUN
admet-881	391	20	motions	motion	NOUN
admet-881	391	21	.	.	PUNCT
admet-881	392	1	physical	physical	ADJ
admet-881	392	2	review	review	NOUN
admet-881	392	3	e	e	PROPN
admet-881	392	4	95	95	NUM
admet-881	392	5	(	(	PUNCT
admet-881	392	6	2017	2017	NUM
admet-881	392	7	)	)	PUNCT
admet-881	392	8	062412	062412	NUM
admet-881	392	9	.	.	PUNCT
admet-881	393	1	[	[	X
admet-881	393	2	50	50	NUM
admet-881	393	3	]	]	X
admet-881	393	4	d.	d.	PROPN
admet-881	393	5	dahlgren	dahlgren	PROPN
admet-881	393	6	,	,	PUNCT
admet-881	393	7	c.	c.	PROPN
admet-881	393	8	roos	roos	PROPN
admet-881	393	9	,	,	PUNCT
admet-881	393	10	p.	p.	NOUN
admet-881	393	11	johansson	johansson	PROPN
admet-881	393	12	,	,	PUNCT
admet-881	393	13	c.	c.	PROPN
admet-881	393	14	tannergren	tannergren	PROPN
admet-881	393	15	,	,	PUNCT
admet-881	393	16	a.	a.	PROPN
admet-881	393	17	lundqvist	lundqvist	PROPN
admet-881	393	18	,	,	PUNCT
admet-881	393	19	p.	p.	PROPN
admet-881	393	20	langguth	langguth	PROPN
admet-881	393	21	,	,	PUNCT
admet-881	393	22	m.	m.	NOUN
admet-881	393	23	sjöblom	sjöblom	PROPN
admet-881	393	24	,	,	PUNCT
admet-881	393	25	e.	e.	PROPN
admet-881	393	26	sjögren	sjögren	PROPN
admet-881	393	27	,	,	PUNCT
admet-881	393	28	h.	h.	PROPN
admet-881	393	29	lennernas	lennernas	PROPN
admet-881	393	30	.	.	PUNCT
admet-881	394	1	the	the	DET
admet-881	394	2	effects	effect	NOUN
admet-881	394	3	of	of	ADP
admet-881	394	4	three	three	NUM
admet-881	394	5	absorption	absorption	NOUN
admet-881	394	6	-	-	PUNCT
admet-881	394	7	modifying	modify	VERB
admet-881	394	8	critical	critical	ADJ
admet-881	394	9	excipients	excipient	NOUN
admet-881	394	10	on	on	ADP
admet-881	394	11	the	the	DET
admet-881	394	12	in	in	ADJ
admet-881	394	13	vivo	vivo	ADJ
admet-881	394	14	intestinal	intestinal	ADJ
admet-881	394	15	absorption	absorption	NOUN
admet-881	394	16	of	of	ADP
admet-881	394	17	six	six	NUM
admet-881	394	18	model	model	NOUN
admet-881	394	19	compounds	compound	NOUN
admet-881	394	20	in	in	ADP
admet-881	394	21	rats	rat	NOUN
admet-881	394	22	and	and	CCONJ
admet-881	394	23	dogs	dog	NOUN
admet-881	394	24	.	.	PUNCT
admet-881	395	1	international	international	ADJ
admet-881	395	2	journal	journal	PROPN
admet-881	395	3	of	of	ADP
admet-881	395	4	pharmaceutics	pharmaceutic	NOUN
admet-881	395	5	547	547	NUM
admet-881	395	6	(	(	PUNCT
admet-881	395	7	2018	2018	NUM
admet-881	395	8	)	)	PUNCT
admet-881	395	9	158	158	NUM
admet-881	395	10	-	-	SYM
admet-881	395	11	168	168	NUM
admet-881	395	12	.	.	PUNCT
admet-881	396	1	[	[	X
admet-881	396	2	51	51	NUM
admet-881	396	3	]	]	X
admet-881	396	4	e.	e.	PROPN
admet-881	396	5	sjödin	sjödin	PROPN
admet-881	396	6	,	,	PUNCT
admet-881	396	7	h.	h.	PROPN
admet-881	396	8	fritsch	fritsch	PROPN
admet-881	396	9	,	,	PUNCT
admet-881	396	10	u.g	u.g	PROPN
admet-881	396	11	.	.	PROPN
admet-881	396	12	eriksson	eriksson	PROPN
admet-881	396	13	,	,	PUNCT
admet-881	396	14	u.	u.	PROPN
admet-881	396	15	logren	logren	PROPN
admet-881	396	16	,	,	PUNCT
admet-881	396	17	a.	a.	NOUN
admet-881	396	18	nordgren	nordgren	PROPN
admet-881	396	19	,	,	PUNCT
admet-881	396	20	p.	p.	PROPN
admet-881	396	21	forsell	forsell	PROPN
admet-881	396	22	,	,	PUNCT
admet-881	396	23	l.	l.	PROPN
admet-881	396	24	knutson	knutson	PROPN
admet-881	396	25	,	,	PUNCT
admet-881	396	26	h.	h.	PROPN
admet-881	396	27	lennernäs	lennernäs	PROPN
admet-881	396	28	.	.	PUNCT
admet-881	397	1	intestinal	intestinal	ADJ
admet-881	397	2	and	and	CCONJ
admet-881	397	3	hepatobiliary	hepatobiliary	ADJ
admet-881	397	4	transport	transport	NOUN
admet-881	397	5	of	of	ADP
admet-881	397	6	ximelagatran	ximelagatran	NOUN
admet-881	397	7	and	and	CCONJ
admet-881	397	8	its	its	PRON
admet-881	397	9	metabolites	metabolite	NOUN
admet-881	397	10	in	in	ADP
admet-881	397	11	pigs	pig	NOUN
admet-881	397	12	.	.	PUNCT
admet-881	398	1	drug	drug	NOUN
admet-881	398	2	metabolism	metabolism	NOUN
admet-881	398	3	and	and	CCONJ
admet-881	398	4	disposition	disposition	NOUN
admet-881	398	5	36	36	NUM
admet-881	398	6	(	(	PUNCT
admet-881	398	7	2008	2008	NUM
admet-881	398	8	)	)	PUNCT
admet-881	398	9	1519	1519	NUM
admet-881	398	10	-	-	SYM
admet-881	398	11	1528	1528	NUM
admet-881	398	12	.	.	PUNCT
admet-881	399	1	[	[	X
admet-881	399	2	52	52	NUM
admet-881	399	3	]	]	PUNCT
admet-881	399	4	l.	l.	PROPN
admet-881	399	5	bønløkke	bønløkke	PROPN
admet-881	399	6	,	,	PUNCT
admet-881	399	7	l.	l.	PROPN
admet-881	399	8	hovgaard	hovgaard	PROPN
admet-881	399	9	,	,	PUNCT
admet-881	399	10	h.g	h.g	PROPN
admet-881	399	11	.	.	PROPN
admet-881	399	12	kristensen	kristensen	PROPN
admet-881	399	13	,	,	PUNCT
admet-881	399	14	l.	l.	PROPN
admet-881	399	15	knutson	knutson	PROPN
admet-881	399	16	,	,	PUNCT
admet-881	399	17	h.	h.	PROPN
admet-881	399	18	lennernäs	lennernäs	PROPN
admet-881	399	19	.	.	PUNCT
admet-881	400	1	direct	direct	ADJ
admet-881	400	2	estimation	estimation	NOUN
admet-881	400	3	of	of	ADP
admet-881	400	4	the	the	DET
admet-881	400	5	in	in	ADP
admet-881	400	6	vivo	vivo	ADJ
admet-881	400	7	dissolution	dissolution	NOUN
admet-881	400	8	of	of	ADP
admet-881	400	9	spironolactone	spironolactone	PROPN
admet-881	400	10	,	,	PUNCT
admet-881	400	11	in	in	ADP
admet-881	400	12	two	two	NUM
admet-881	400	13	particle	particle	NOUN
admet-881	400	14	size	size	NOUN
admet-881	400	15	ranges	range	NOUN
admet-881	400	16	,	,	PUNCT
admet-881	400	17	using	use	VERB
admet-881	400	18	the	the	DET
admet-881	400	19	single	single	ADJ
admet-881	400	20	-	-	PUNCT
admet-881	400	21	pass	pass	NOUN
admet-881	400	22	perfusion	perfusion	NOUN
admet-881	400	23	technique	technique	NOUN
admet-881	400	24	(	(	PUNCT
admet-881	400	25	loc	loc	X
admet-881	400	26	-	-	PUNCT
admet-881	400	27	i	i	NOUN
admet-881	400	28	-	-	PUNCT
admet-881	400	29	gut	gut	PROPN
admet-881	400	30	®	®	NOUN
admet-881	400	31	)	)	PUNCT
admet-881	400	32	in	in	ADP
admet-881	400	33	humans	human	NOUN
admet-881	400	34	.	.	PUNCT
admet-881	401	1	european	european	ADJ
admet-881	401	2	journal	journal	PROPN
admet-881	401	3	of	of	ADP
admet-881	401	4	pharmaceutical	pharmaceutical	PROPN
admet-881	401	5	sciences	science	NOUN
admet-881	401	6	12	12	NUM
admet-881	401	7	(	(	PUNCT
admet-881	401	8	2001	2001	NUM
admet-881	401	9	)	)	PUNCT
admet-881	401	10	239	239	NUM
admet-881	401	11	-	-	SYM
admet-881	401	12	250	250	NUM
admet-881	401	13	.	.	PUNCT
admet-881	402	1	[	[	X
admet-881	402	2	53	53	NUM
admet-881	402	3	]	]	PUNCT
admet-881	402	4	l.	l.	PROPN
admet-881	402	5	bønløkke	bønløkke	PROPN
admet-881	402	6	,	,	PUNCT
admet-881	402	7	f.n	f.n	PROPN
admet-881	402	8	.	.	PROPN
admet-881	402	9	christensen	christensen	PROPN
admet-881	402	10	,	,	PUNCT
admet-881	402	11	l.	l.	PROPN
admet-881	402	12	knutson	knutson	PROPN
admet-881	402	13	,	,	PUNCT
admet-881	402	14	h.g	h.g	PROPN
admet-881	402	15	.	.	PROPN
admet-881	402	16	kristensen	kristensen	PROPN
admet-881	402	17	,	,	PUNCT
admet-881	402	18	h.	h.	PROPN
admet-881	402	19	lennernäs	lennernäs	PROPN
admet-881	402	20	.	.	PUNCT
admet-881	403	1	a	a	DET
admet-881	403	2	new	new	ADJ
admet-881	403	3	approach	approach	NOUN
admet-881	403	4	for	for	ADP
admet-881	403	5	direct	direct	ADJ
admet-881	403	6	in	in	ADP
admet-881	403	7	vivo	vivo	ADJ
admet-881	403	8	dissolution	dissolution	NOUN
admet-881	403	9	studies	study	NOUN
admet-881	403	10	of	of	ADP
admet-881	403	11	poorly	poorly	ADV
admet-881	403	12	soluble	soluble	ADJ
admet-881	403	13	drugs	drug	NOUN
admet-881	403	14	.	.	PUNCT
admet-881	404	1	pharmaceutical	pharmaceutical	ADJ
admet-881	404	2	research	research	NOUN
admet-881	404	3	14	14	NUM
admet-881	404	4	(	(	PUNCT
admet-881	404	5	1997	1997	NUM
admet-881	404	6	)	)	PUNCT
admet-881	404	7	1490	1490	NUM
admet-881	404	8	-	-	SYM
admet-881	404	9	1492	1492	NUM
admet-881	404	10	.	.	PUNCT
admet-881	405	1	[	[	X
admet-881	405	2	54	54	NUM
admet-881	405	3	]	]	X
admet-881	405	4	d.	d.	PROPN
admet-881	405	5	dahlgren	dahlgren	PROPN
admet-881	405	6	,	,	PUNCT
admet-881	405	7	c.	c.	PROPN
admet-881	405	8	roos	roos	PROPN
admet-881	405	9	,	,	PUNCT
admet-881	405	10	e.	e.	PROPN
admet-881	405	11	sjögren	sjögren	PROPN
admet-881	405	12	,	,	PUNCT
admet-881	405	13	h.	h.	PROPN
admet-881	405	14	lennernäs	lennernäs	PROPN
admet-881	405	15	.	.	PUNCT
admet-881	406	1	direct	direct	ADJ
admet-881	406	2	in	in	ADP
admet-881	406	3	vivo	vivo	ADJ
admet-881	406	4	human	human	ADJ
admet-881	406	5	intestinal	intestinal	ADJ
admet-881	406	6	permeability	permeability	NOUN
admet-881	406	7	(	(	PUNCT
admet-881	406	8	peff	peff	PROPN
admet-881	406	9	)	)	PUNCT
admet-881	406	10	determined	determine	VERB
admet-881	406	11	with	with	ADP
admet-881	406	12	different	different	ADJ
admet-881	406	13	clinical	clinical	ADJ
admet-881	406	14	perfusion	perfusion	NOUN
admet-881	406	15	and	and	CCONJ
admet-881	406	16	intubation	intubation	NOUN
admet-881	406	17	methods	method	NOUN
admet-881	406	18	.	.	PUNCT
admet-881	407	1	journal	journal	NOUN
admet-881	407	2	of	of	ADP
admet-881	407	3	pharmaceutical	pharmaceutical	PROPN
admet-881	407	4	sciences	science	NOUN
admet-881	407	5	104	104	NUM
admet-881	407	6	(	(	PUNCT
admet-881	407	7	2014	2014	NUM
admet-881	407	8	)	)	PUNCT
admet-881	407	9	2702	2702	NUM
admet-881	407	10	-	-	SYM
admet-881	407	11	2726	2726	NUM
admet-881	407	12	.	.	PUNCT
admet-881	408	1	[	[	X
admet-881	408	2	55	55	NUM
admet-881	408	3	]	]	X
admet-881	408	4	e.m	e.m	PROPN
admet-881	408	5	.	.	PROPN
admet-881	408	6	persson	persson	PROPN
admet-881	408	7	,	,	PUNCT
admet-881	408	8	a.	a.	NOUN
admet-881	408	9	nordgren	nordgren	PROPN
admet-881	408	10	,	,	PUNCT
admet-881	408	11	p.	p.	PROPN
admet-881	408	12	forsell	forsell	PROPN
admet-881	408	13	,	,	PUNCT
admet-881	408	14	l.	l.	PROPN
admet-881	408	15	knutson	knutson	PROPN
admet-881	408	16	,	,	PUNCT
admet-881	408	17	c.	c.	PROPN
admet-881	408	18	öhgren	öhgren	PROPN
admet-881	408	19	,	,	PUNCT
admet-881	408	20	s.	s.	PROPN
admet-881	408	21	forssén	forssén	PROPN
admet-881	408	22	,	,	PUNCT
admet-881	408	23	h.	h.	PROPN
admet-881	408	24	lennernäs	lennernäs	PROPN
admet-881	408	25	,	,	PUNCT
admet-881	408	26	b.	b.	PROPN
admet-881	408	27	abrahamsson	abrahamsson	PROPN
admet-881	408	28	.	.	PUNCT
admet-881	409	1	improved	improve	VERB
admet-881	409	2	understanding	understanding	NOUN
admet-881	409	3	of	of	ADP
admet-881	409	4	the	the	DET
admet-881	409	5	effect	effect	NOUN
admet-881	409	6	of	of	ADP
admet-881	409	7	food	food	NOUN
admet-881	409	8	on	on	ADP
admet-881	409	9	drug	drug	NOUN
admet-881	409	10	absorption	absorption	NOUN
admet-881	409	11	and	and	CCONJ
admet-881	409	12	bioavailability	bioavailability	NOUN
admet-881	409	13	for	for	ADP
admet-881	409	14	lipophilic	lipophilic	ADJ
admet-881	409	15	compounds	compound	NOUN
admet-881	409	16	using	use	VERB
admet-881	409	17	an	an	DET
admet-881	409	18	intestinal	intestinal	ADJ
admet-881	409	19	pig	pig	NOUN
admet-881	409	20	perfusion	perfusion	NOUN
admet-881	409	21	model	model	NOUN
admet-881	409	22	.	.	PUNCT
admet-881	410	1	european	european	PROPN
admet-881	410	2	journal	journal	PROPN
admet-881	410	3	of	of	ADP
admet-881	410	4	pharmaceutical	pharmaceutical	PROPN
admet-881	410	5	sciences	science	NOUN
admet-881	410	6	34	34	NUM
admet-881	410	7	(	(	PUNCT
admet-881	410	8	2008	2008	NUM
admet-881	410	9	)	)	PUNCT
admet-881	410	10	22	22	NUM
admet-881	410	11	-	-	SYM
admet-881	410	12	29	29	NUM
admet-881	410	13	.	.	PUNCT
admet-881	411	1	[	[	X
admet-881	411	2	56	56	NUM
admet-881	411	3	]	]	X
admet-881	411	4	h.	h.	PROPN
admet-881	411	5	lennernäs	lennernäs	PROPN
admet-881	411	6	,	,	PUNCT
admet-881	411	7	ö.	ö.	PROPN
admet-881	411	8	ahrenstedt	ahrenstedt	PROPN
admet-881	411	9	,	,	PUNCT
admet-881	411	10	r.	r.	PROPN
admet-881	411	11	hällgren	hällgren	PROPN
admet-881	411	12	,	,	PUNCT
admet-881	411	13	l.	l.	PROPN
admet-881	411	14	knutson	knutson	PROPN
admet-881	411	15	,	,	PUNCT
admet-881	411	16	m.	m.	PROPN
admet-881	411	17	ryde	ryde	PROPN
admet-881	411	18	,	,	PUNCT
admet-881	411	19	l.k	l.k	PROPN
admet-881	411	20	.	.	PROPN
admet-881	411	21	paalzow	paalzow	PROPN
admet-881	411	22	.	.	PUNCT
admet-881	412	1	regional	regional	ADJ
admet-881	412	2	jejunal	jejunal	ADJ
admet-881	412	3	perfusion	perfusion	NOUN
admet-881	412	4	,	,	PUNCT
admet-881	412	5	a	a	DET
admet-881	412	6	new	new	ADJ
admet-881	412	7	in	in	ADP
admet-881	412	8	vivo	vivo	ADJ
admet-881	412	9	approach	approach	NOUN
admet-881	412	10	to	to	PART
admet-881	412	11	study	study	VERB
admet-881	412	12	oral	oral	ADJ
admet-881	412	13	drug	drug	NOUN
admet-881	412	14	absorption	absorption	NOUN
admet-881	412	15	in	in	ADP
admet-881	412	16	man	man	NOUN
admet-881	412	17	.	.	PUNCT
admet-881	413	1	pharmaceutical	pharmaceutical	ADJ
admet-881	413	2	research	research	NOUN
admet-881	413	3	9	9	NUM
admet-881	413	4	(	(	PUNCT
admet-881	413	5	1992	1992	NUM
admet-881	413	6	)	)	PUNCT
admet-881	413	7	1243	1243	NUM
admet-881	413	8	-	-	SYM
admet-881	413	9	1251	1251	NUM
admet-881	413	10	.	.	PUNCT
admet-881	414	1	[	[	X
admet-881	414	2	57	57	NUM
admet-881	414	3	]	]	X
admet-881	414	4	s.c	s.c	PROPN
admet-881	414	5	.	.	PROPN
admet-881	414	6	sutton	sutton	PROPN
admet-881	414	7	,	,	PUNCT
admet-881	414	8	m.	m.	PROPN
admet-881	414	9	rinaldi	rinaldi	PROPN
admet-881	414	10	,	,	PUNCT
admet-881	414	11	k.	k.	PROPN
admet-881	414	12	vukovinsky	vukovinsky	PROPN
admet-881	414	13	.	.	PUNCT
admet-881	415	1	comparison	comparison	NOUN
admet-881	415	2	of	of	ADP
admet-881	415	3	the	the	DET
admet-881	415	4	gravimetric	gravimetric	ADJ
admet-881	415	5	,	,	PUNCT
admet-881	415	6	phenol	phenol	ADJ
admet-881	415	7	red	red	NOUN
admet-881	415	8	,	,	PUNCT
admet-881	415	9	and	and	CCONJ
admet-881	415	10	14c	14c	NOUN
admet-881	415	11	-	-	PUNCT
admet-881	415	12	peg-3350	peg-3350	NOUN
admet-881	415	13	methods	method	NOUN
admet-881	415	14	to	to	PART
admet-881	415	15	determine	determine	VERB
admet-881	415	16	water	water	NOUN
admet-881	415	17	absorption	absorption	NOUN
admet-881	415	18	in	in	ADP
admet-881	415	19	the	the	DET
admet-881	415	20	rat	rat	NOUN
admet-881	415	21	single	single	ADJ
admet-881	415	22	-	-	PUNCT
admet-881	415	23	pass	pass	ADJ
admet-881	415	24	intestinal	intestinal	ADJ
admet-881	415	25	perfusion	perfusion	NOUN
admet-881	415	26	model	model	NOUN
admet-881	415	27	.	.	PUNCT
admet-881	416	1	aaps	aap	NOUN
admet-881	416	2	pharmsci	pharmsci	VERB
admet-881	416	3	3	3	NUM
admet-881	416	4	(	(	PUNCT
admet-881	416	5	2001	2001	NUM
admet-881	416	6	)	)	PUNCT
admet-881	416	7	93	93	NUM
admet-881	416	8	.	.	PUNCT
admet-881	417	1	[	[	X
admet-881	417	2	58	58	NUM
admet-881	417	3	]	]	X
admet-881	417	4	h.	h.	PROPN
admet-881	417	5	lennernäs	lennernäs	PROPN
admet-881	417	6	,	,	PUNCT
admet-881	417	7	i.d	i.d	PROPN
admet-881	417	8	.	.	PROPN
admet-881	417	9	lee	lee	PROPN
admet-881	417	10	,	,	PUNCT
admet-881	417	11	u.	u.	PROPN
admet-881	417	12	fagerholm	fagerholm	PROPN
admet-881	417	13	,	,	PUNCT
admet-881	417	14	g.l	g.l	PROPN
admet-881	417	15	.	.	PROPN
admet-881	417	16	amidon	amidon	PROPN
admet-881	417	17	.	.	PUNCT
admet-881	418	1	a	a	DET
admet-881	418	2	residence‐time	residence‐time	NOUN
admet-881	418	3	distribution	distribution	NOUN
admet-881	418	4	analysis	analysis	NOUN
admet-881	418	5	of	of	ADP
admet-881	418	6	the	the	DET
admet-881	418	7	hydrodynamics	hydrodynamic	NOUN
admet-881	418	8	within	within	ADP
admet-881	418	9	the	the	DET
admet-881	418	10	intestine	intestine	NOUN
admet-881	418	11	in	in	ADP
admet-881	418	12	man	man	NOUN
admet-881	418	13	during	during	ADP
admet-881	418	14	a	a	DET
admet-881	418	15	regional	regional	ADJ
admet-881	418	16	single‐pass	single‐pass	ADJ
admet-881	418	17	perfusion	perfusion	NOUN
admet-881	418	18	with	with	ADP
admet-881	418	19	loc‐i‐gut	loc‐i‐gut	PROPN
admet-881	418	20	:	:	PUNCT
admet-881	418	21	in‐	in‐	SCONJ
admet-881	418	22	vivo	vivo	VERB
admet-881	418	23	permeability	permeability	NOUN
admet-881	418	24	estimation	estimation	NOUN
admet-881	418	25	.	.	PUNCT
admet-881	419	1	journal	journal	NOUN
admet-881	419	2	of	of	ADP
admet-881	419	3	pharmacy	pharmacy	NOUN
admet-881	419	4	and	and	CCONJ
admet-881	419	5	pharmacology	pharmacology	NOUN
admet-881	419	6	49	49	NUM
admet-881	419	7	(	(	PUNCT
admet-881	419	8	1997	1997	NUM
admet-881	419	9	)	)	PUNCT
admet-881	419	10	682	682	NUM
admet-881	419	11	-	-	SYM
admet-881	419	12	686	686	NUM
admet-881	419	13	.	.	PUNCT
admet-881	420	1	admet	admet	PROPN
admet-881	420	2	&	&	CCONJ
admet-881	420	3	dmpk	dmpk	PROPN
admet-881	420	4	8(4	8(4	NOUN
admet-881	420	5	)	)	PUNCT
admet-881	420	6	(	(	PUNCT
admet-881	420	7	2020	2020	NUM
admet-881	420	8	)	)	PUNCT
admet-881	420	9	375	375	NUM
admet-881	420	10	-	-	SYM
admet-881	420	11	390	390	NUM
admet-881	420	12	intestinal	intestinal	ADJ
admet-881	420	13	absorption	absorption	NOUN
admet-881	420	14	of	of	ADP
admet-881	420	15	bcs	bcs	NOUN
admet-881	420	16	class	class	NOUN
admet-881	420	17	ii	ii	PROPN
admet-881	420	18	drugs	drug	NOUN
admet-881	420	19	nanoparticles	nanoparticle	NOUN
admet-881	420	20	doi	doi	NOUN
admet-881	420	21	:	:	PUNCT
admet-881	420	22	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	NOUN
admet-881	420	23	389	389	NUM
admet-881	420	24	[	[	X
admet-881	420	25	59	59	NUM
admet-881	420	26	]	]	PUNCT
admet-881	420	27	h.	h.	PROPN
admet-881	420	28	lennernas	lennernas	PROPN
admet-881	420	29	.	.	PUNCT
admet-881	421	1	human	human	ADJ
admet-881	421	2	jejunal	jejunal	ADJ
admet-881	421	3	effective	effective	ADJ
admet-881	421	4	permeability	permeability	NOUN
admet-881	421	5	and	and	CCONJ
admet-881	421	6	its	its	PRON
admet-881	421	7	correlation	correlation	NOUN
admet-881	421	8	with	with	ADP
admet-881	421	9	preclinical	preclinical	ADJ
admet-881	421	10	drug	drug	NOUN
admet-881	421	11	absorption	absorption	NOUN
admet-881	421	12	models	model	NOUN
admet-881	421	13	.	.	PUNCT
admet-881	422	1	journal	journal	NOUN
admet-881	422	2	of	of	ADP
admet-881	422	3	pharmacy	pharmacy	NOUN
admet-881	422	4	and	and	CCONJ
admet-881	422	5	pharmacology	pharmacology	NOUN
admet-881	422	6	49	49	NUM
admet-881	422	7	(	(	PUNCT
admet-881	422	8	1997	1997	NUM
admet-881	422	9	)	)	PUNCT
admet-881	422	10	627	627	NUM
admet-881	422	11	-	-	SYM
admet-881	422	12	638	638	NUM
admet-881	422	13	.	.	PUNCT
admet-881	423	1	[	[	X
admet-881	423	2	60	60	NUM
admet-881	423	3	]	]	X
admet-881	423	4	e.	e.	PROPN
admet-881	423	5	sjögren	sjögren	PROPN
admet-881	423	6	,	,	PUNCT
admet-881	423	7	j.	j.	PROPN
admet-881	423	8	westergren	westergren	PROPN
admet-881	423	9	,	,	PUNCT
admet-881	423	10	i.	i.	PROPN
admet-881	423	11	grant	grant	PROPN
admet-881	423	12	,	,	PUNCT
admet-881	423	13	g.	g.	PROPN
admet-881	423	14	hanisch	hanisch	PROPN
admet-881	423	15	,	,	PUNCT
admet-881	423	16	l.	l.	PROPN
admet-881	423	17	lindfors	lindfors	PROPN
admet-881	423	18	,	,	PUNCT
admet-881	423	19	h.	h.	PROPN
admet-881	423	20	lennernäs	lennernäs	PROPN
admet-881	423	21	,	,	PUNCT
admet-881	423	22	b.	b.	PROPN
admet-881	423	23	abrahamsson	abrahamsson	PROPN
admet-881	423	24	,	,	PUNCT
admet-881	423	25	c.	c.	PROPN
admet-881	423	26	tannergren	tannergren	PROPN
admet-881	423	27	.	.	PUNCT
admet-881	424	1	in	in	ADP
admet-881	424	2	silico	silico	NOUN
admet-881	424	3	predictions	prediction	NOUN
admet-881	424	4	of	of	ADP
admet-881	424	5	gastrointestinal	gastrointestinal	ADJ
admet-881	424	6	drug	drug	NOUN
admet-881	424	7	absorption	absorption	NOUN
admet-881	424	8	in	in	ADP
admet-881	424	9	pharmaceutical	pharmaceutical	ADJ
admet-881	424	10	product	product	NOUN
admet-881	424	11	development	development	NOUN
admet-881	424	12	:	:	PUNCT
admet-881	424	13	application	application	NOUN
admet-881	424	14	of	of	ADP
admet-881	424	15	the	the	DET
admet-881	424	16	mechanistic	mechanistic	ADJ
admet-881	424	17	absorption	absorption	NOUN
admet-881	424	18	model	model	NOUN
admet-881	424	19	gi	gi	NOUN
admet-881	424	20	-	-	PUNCT
admet-881	424	21	sim	sim	NOUN
admet-881	424	22	.	.	PUNCT
admet-881	425	1	european	european	PROPN
admet-881	425	2	journal	journal	PROPN
admet-881	425	3	of	of	ADP
admet-881	425	4	pharmaceutical	pharmaceutical	PROPN
admet-881	425	5	sciences	science	NOUN
admet-881	425	6	(	(	PUNCT
admet-881	425	7	2013	2013	NUM
admet-881	425	8	)	)	PUNCT
admet-881	425	9	.	.	PUNCT
admet-881	426	1	[	[	X
admet-881	426	2	61	61	NUM
admet-881	426	3	]	]	X
admet-881	426	4	t.m	t.m	PROPN
admet-881	426	5	.	.	PROPN
admet-881	426	6	dando	dando	PROPN
admet-881	426	7	,	,	PUNCT
admet-881	426	8	c.m	c.m	PROPN
admet-881	426	9	.	.	PROPN
admet-881	426	10	perry	perry	PROPN
admet-881	426	11	.	.	PUNCT
admet-881	426	12	aprepitant	aprepitant	PROPN
admet-881	426	13	.	.	PUNCT
admet-881	427	1	drugs	drug	NOUN
admet-881	427	2	64	64	NUM
admet-881	427	3	(	(	PUNCT
admet-881	427	4	2004	2004	NUM
admet-881	427	5	)	)	PUNCT
admet-881	427	6	777	777	NUM
admet-881	427	7	-	-	SYM
admet-881	427	8	794	794	NUM
admet-881	427	9	.	.	PUNCT
admet-881	428	1	[	[	X
admet-881	428	2	62	62	NUM
admet-881	428	3	]	]	PUNCT
admet-881	428	4	c.	c.	PROPN
admet-881	428	5	tannergren	tannergren	PROPN
admet-881	428	6	,	,	PUNCT
admet-881	428	7	a.	a.	PROPN
admet-881	428	8	bergendal	bergendal	PROPN
admet-881	428	9	,	,	PUNCT
admet-881	428	10	h.	h.	PROPN
admet-881	428	11	lennernäs	lennernäs	PROPN
admet-881	428	12	,	,	PUNCT
admet-881	428	13	b.	b.	PROPN
admet-881	428	14	abrahamsson	abrahamsson	PROPN
admet-881	428	15	.	.	PUNCT
admet-881	429	1	toward	toward	ADP
admet-881	429	2	an	an	DET
admet-881	429	3	increased	increase	VERB
admet-881	429	4	understanding	understanding	NOUN
admet-881	429	5	of	of	ADP
admet-881	429	6	the	the	DET
admet-881	429	7	barriers	barrier	NOUN
admet-881	429	8	to	to	ADP
admet-881	429	9	colonic	colonic	ADJ
admet-881	429	10	drug	drug	NOUN
admet-881	429	11	absorption	absorption	NOUN
admet-881	429	12	in	in	ADP
admet-881	429	13	humans	human	NOUN
admet-881	429	14	:	:	PUNCT
admet-881	429	15	implications	implication	NOUN
admet-881	429	16	for	for	ADP
admet-881	429	17	early	early	ADJ
admet-881	429	18	controlled	control	VERB
admet-881	429	19	release	release	NOUN
admet-881	429	20	candidate	candidate	NOUN
admet-881	429	21	assessment	assessment	NOUN
admet-881	429	22	.	.	PUNCT
admet-881	430	1	molecular	molecular	ADJ
admet-881	430	2	pharmaceutics	pharmaceutic	NOUN
admet-881	430	3	6	6	NUM
admet-881	430	4	(	(	PUNCT
admet-881	430	5	2009	2009	NUM
admet-881	430	6	)	)	PUNCT
admet-881	430	7	60	60	NUM
admet-881	430	8	-	-	SYM
admet-881	430	9	73	73	NUM
admet-881	430	10	.	.	PUNCT
admet-881	431	1	[	[	X
admet-881	431	2	63	63	NUM
admet-881	431	3	]	]	PUNCT
admet-881	431	4	c.	c.	NOUN
admet-881	431	5	roos	roos	PROPN
admet-881	431	6	,	,	PUNCT
admet-881	431	7	d.	d.	PROPN
admet-881	431	8	dahlgren	dahlgren	PROPN
admet-881	431	9	,	,	PUNCT
admet-881	431	10	s.	s.	PROPN
admet-881	431	11	berg	berg	PROPN
admet-881	431	12	,	,	PUNCT
admet-881	431	13	j.	j.	PROPN
admet-881	431	14	westergren	westergren	PROPN
admet-881	431	15	,	,	PUNCT
admet-881	431	16	b.	b.	PROPN
admet-881	431	17	abrahamsson	abrahamsson	PROPN
admet-881	431	18	,	,	PUNCT
admet-881	431	19	c.	c.	PROPN
admet-881	431	20	tannergren	tannergren	PROPN
admet-881	431	21	,	,	PUNCT
admet-881	431	22	e.	e.	PROPN
admet-881	431	23	sjögren	sjögren	PROPN
admet-881	431	24	,	,	PUNCT
admet-881	431	25	h.	h.	PROPN
admet-881	431	26	lennernäs	lennernäs	PROPN
admet-881	431	27	.	.	PUNCT
admet-881	432	1	in	in	ADP
admet-881	432	2	vivo	vivo	ADJ
admet-881	432	3	mechanisms	mechanism	NOUN
admet-881	432	4	of	of	ADP
admet-881	432	5	intestinal	intestinal	ADJ
admet-881	432	6	drug	drug	NOUN
admet-881	432	7	absorption	absorption	NOUN
admet-881	432	8	from	from	ADP
admet-881	432	9	aprepitant	aprepitant	ADJ
admet-881	432	10	nanoformulations	nanoformulation	NOUN
admet-881	432	11	.	.	PUNCT
admet-881	433	1	molecular	molecular	ADJ
admet-881	433	2	pharmaceutics	pharmaceutic	NOUN
admet-881	433	3	14	14	NUM
admet-881	433	4	(	(	PUNCT
admet-881	433	5	2017	2017	NUM
admet-881	433	6	)	)	PUNCT
admet-881	433	7	4233	4233	NUM
admet-881	433	8	-	-	SYM
admet-881	433	9	4242	4242	NUM
admet-881	433	10	.	.	PUNCT
admet-881	434	1	[	[	X
admet-881	434	2	64	64	NUM
admet-881	434	3	]	]	X
admet-881	434	4	r.i	r.i	PROPN
admet-881	434	5	.	.	PROPN
admet-881	434	6	sanchez	sanchez	PROPN
admet-881	434	7	,	,	PUNCT
admet-881	434	8	r.w	r.w	PROPN
admet-881	434	9	.	.	PROPN
admet-881	434	10	wang	wang	PROPN
admet-881	434	11	,	,	PUNCT
admet-881	434	12	d.j	d.j	PROPN
admet-881	434	13	.	.	PROPN
admet-881	434	14	newton	newton	PROPN
admet-881	434	15	,	,	PUNCT
admet-881	434	16	r.	r.	PROPN
admet-881	434	17	bakhtiar	bakhtiar	PROPN
admet-881	434	18	,	,	PUNCT
admet-881	434	19	p.	p.	PROPN
admet-881	434	20	lu	lu	PROPN
admet-881	434	21	,	,	PUNCT
admet-881	434	22	s.-h.l	s.-h.l	PROPN
admet-881	434	23	.	.	PUNCT
admet-881	435	1	chiu	chiu	PROPN
admet-881	435	2	,	,	PUNCT
admet-881	435	3	d.c	d.c	PROPN
admet-881	435	4	.	.	PROPN
admet-881	435	5	evans	evans	PROPN
admet-881	435	6	,	,	PUNCT
admet-881	435	7	s.-e.w	s.-e.w	PROPN
admet-881	435	8	.	.	PUNCT
admet-881	435	9	huskey	huskey	PROPN
admet-881	435	10	.	.	PUNCT
admet-881	436	1	cytochrome	cytochrome	PROPN
admet-881	436	2	p450	p450	PROPN
admet-881	436	3	3a4	3a4	NUM
admet-881	436	4	is	be	AUX
admet-881	436	5	the	the	DET
admet-881	436	6	major	major	ADJ
admet-881	436	7	enzyme	enzyme	NOUN
admet-881	436	8	involved	involve	VERB
admet-881	436	9	in	in	ADP
admet-881	436	10	the	the	DET
admet-881	436	11	metabolism	metabolism	NOUN
admet-881	436	12	of	of	ADP
admet-881	436	13	the	the	DET
admet-881	436	14	substance	substance	NOUN
admet-881	436	15	p	p	NOUN
admet-881	436	16	receptor	receptor	NOUN
admet-881	436	17	antagonist	antagonist	NOUN
admet-881	436	18	aprepitant	aprepitant	ADJ
admet-881	436	19	.	.	PUNCT
admet-881	437	1	drug	drug	NOUN
admet-881	437	2	metabolism	metabolism	NOUN
admet-881	437	3	and	and	CCONJ
admet-881	437	4	disposition	disposition	NOUN
admet-881	437	5	32	32	NUM
admet-881	437	6	(	(	PUNCT
admet-881	437	7	2004	2004	NUM
admet-881	437	8	)	)	PUNCT
admet-881	437	9	1287	1287	NUM
admet-881	437	10	-	-	SYM
admet-881	437	11	1292	1292	NUM
admet-881	437	12	.	.	PUNCT
admet-881	438	1	[	[	X
admet-881	438	2	65	65	NUM
admet-881	438	3	]	]	X
admet-881	438	4	r.	r.	PROPN
admet-881	438	5	hargreaves	hargreaves	PROPN
admet-881	438	6	,	,	PUNCT
admet-881	438	7	j.c.a	j.c.a	PROPN
admet-881	438	8	.	.	PUNCT
admet-881	439	1	ferreira	ferreira	PROPN
admet-881	439	2	,	,	PUNCT
admet-881	439	3	d.	d.	PROPN
admet-881	439	4	hughes	hughes	PROPN
admet-881	439	5	,	,	PUNCT
admet-881	439	6	j.	j.	PROPN
admet-881	439	7	brands	brands	PROPN
admet-881	439	8	,	,	PUNCT
admet-881	439	9	j.	j.	PROPN
admet-881	439	10	hale	hale	PROPN
admet-881	439	11	,	,	PUNCT
admet-881	439	12	b.	b.	PROPN
admet-881	439	13	mattson	mattson	PROPN
admet-881	439	14	,	,	PUNCT
admet-881	439	15	s.	s.	PROPN
admet-881	439	16	mills	mills	PROPN
admet-881	439	17	.	.	PUNCT
admet-881	440	1	development	development	NOUN
admet-881	440	2	of	of	ADP
admet-881	440	3	aprepitant	aprepitant	ADJ
admet-881	440	4	,	,	PUNCT
admet-881	440	5	the	the	DET
admet-881	440	6	first	first	ADJ
admet-881	440	7	neurokinin‐1	neurokinin‐1	NOUN
admet-881	440	8	receptor	receptor	NOUN
admet-881	440	9	antagonist	antagonist	NOUN
admet-881	440	10	for	for	ADP
admet-881	440	11	the	the	DET
admet-881	440	12	prevention	prevention	NOUN
admet-881	440	13	of	of	ADP
admet-881	440	14	chemotherapy‐induced	chemotherapy‐induced	ADJ
admet-881	440	15	nausea	nausea	NOUN
admet-881	440	16	and	and	CCONJ
admet-881	440	17	vomiting	vomiting	NOUN
admet-881	440	18	.	.	PUNCT
admet-881	441	1	annals	annal	NOUN
admet-881	441	2	of	of	ADP
admet-881	441	3	the	the	DET
admet-881	441	4	new	new	PROPN
admet-881	441	5	york	york	PROPN
admet-881	441	6	academy	academy	PROPN
admet-881	441	7	of	of	ADP
admet-881	441	8	sciences	science	NOUN
admet-881	441	9	1222	1222	NUM
admet-881	441	10	(	(	PUNCT
admet-881	441	11	2011	2011	NUM
admet-881	441	12	)	)	PUNCT
admet-881	441	13	40	40	NUM
admet-881	441	14	-	-	SYM
admet-881	441	15	48	48	NUM
admet-881	441	16	.	.	PUNCT
admet-881	442	1	[	[	X
admet-881	442	2	66	66	NUM
admet-881	442	3	]	]	X
admet-881	442	4	p.f	p.f	PROPN
admet-881	442	5	.	.	PROPN
admet-881	442	6	augustijns	augustijns	NOUN
admet-881	442	7	,	,	PUNCT
admet-881	442	8	t.p	t.p	PROPN
admet-881	442	9	.	.	PROPN
admet-881	442	10	bradshaw	bradshaw	PROPN
admet-881	442	11	,	,	PUNCT
admet-881	442	12	l.-s.l	l.-s.l	PROPN
admet-881	442	13	.	.	PUNCT
admet-881	442	14	gan	gan	PROPN
admet-881	442	15	,	,	PUNCT
admet-881	442	16	r.w	r.w	PROPN
admet-881	442	17	.	.	PROPN
admet-881	442	18	hendren	hendren	PROPN
admet-881	442	19	,	,	PUNCT
admet-881	442	20	d.r	d.r	PROPN
admet-881	442	21	.	.	PROPN
admet-881	442	22	thakker	thakker	PROPN
admet-881	442	23	.	.	PUNCT
admet-881	443	1	evidence	evidence	NOUN
admet-881	443	2	for	for	ADP
admet-881	443	3	a	a	DET
admet-881	443	4	polarized	polarize	VERB
admet-881	443	5	efflux	efflux	NOUN
admet-881	443	6	system	system	NOUN
admet-881	443	7	in	in	ADP
admet-881	443	8	caco-2	caco-2	NUM
admet-881	443	9	cells	cell	NOUN
admet-881	443	10	capable	capable	ADJ
admet-881	443	11	of	of	ADP
admet-881	443	12	modulating	modulate	VERB
admet-881	443	13	cyclosporine	cyclosporine	NOUN
admet-881	443	14	a	a	DET
admet-881	443	15	transport	transport	NOUN
admet-881	443	16	.	.	PUNCT
admet-881	444	1	biochemical	biochemical	ADJ
admet-881	444	2	and	and	CCONJ
admet-881	444	3	biophysical	biophysical	ADJ
admet-881	444	4	research	research	NOUN
admet-881	444	5	communications	communication	NOUN
admet-881	444	6	197	197	NUM
admet-881	444	7	(	(	PUNCT
admet-881	444	8	1993	1993	NUM
admet-881	444	9	)	)	PUNCT
admet-881	444	10	360	360	NUM
admet-881	444	11	-	-	SYM
admet-881	444	12	365	365	NUM
admet-881	444	13	.	.	PUNCT
admet-881	445	1	[	[	X
admet-881	445	2	67	67	NUM
admet-881	445	3	]	]	PUNCT
admet-881	445	4	t.	t.	PROPN
admet-881	445	5	saeki	saeki	PROPN
admet-881	445	6	,	,	PUNCT
admet-881	445	7	k.	k.	PROPN
admet-881	445	8	ueda	ueda	PROPN
admet-881	445	9	,	,	PUNCT
admet-881	445	10	y.	y.	PROPN
admet-881	445	11	tanigawara	tanigawara	PROPN
admet-881	445	12	,	,	PUNCT
admet-881	445	13	r.	r.	PROPN
admet-881	445	14	hori	hori	PROPN
admet-881	445	15	,	,	PUNCT
admet-881	445	16	t.	t.	PROPN
admet-881	445	17	komano	komano	PROPN
admet-881	445	18	.	.	PUNCT
admet-881	446	1	human	human	ADJ
admet-881	446	2	p	p	NOUN
admet-881	446	3	-	-	PUNCT
admet-881	446	4	glycoprotein	glycoprotein	NOUN
admet-881	446	5	transports	transport	NOUN
admet-881	446	6	cyclosporin	cyclosporin	NOUN
admet-881	446	7	a	a	PRON
admet-881	446	8	and	and	CCONJ
admet-881	446	9	fk506	fk506	PROPN
admet-881	446	10	.	.	PROPN
admet-881	447	1	journal	journal	PROPN
admet-881	447	2	of	of	ADP
admet-881	447	3	biological	biological	ADJ
admet-881	447	4	chemistry	chemistry	NOUN
admet-881	447	5	268	268	NUM
admet-881	447	6	(	(	PUNCT
admet-881	447	7	1993	1993	NUM
admet-881	447	8	)	)	PUNCT
admet-881	447	9	6077	6077	NUM
admet-881	447	10	-	-	SYM
admet-881	447	11	6080	6080	NUM
admet-881	447	12	.	.	PUNCT
admet-881	448	1	[	[	X
admet-881	448	2	68	68	NUM
admet-881	448	3	]	]	PUNCT
admet-881	448	4	t.	t.	PROPN
admet-881	448	5	kronbach	kronbach	PROPN
admet-881	448	6	,	,	PUNCT
admet-881	448	7	v.	v.	PROPN
admet-881	448	8	fischer	fischer	PROPN
admet-881	448	9	,	,	PUNCT
admet-881	448	10	u.a	u.a	PROPN
admet-881	448	11	.	.	PROPN
admet-881	448	12	meyer	meyer	PROPN
admet-881	448	13	.	.	PROPN
admet-881	448	14	cyclosporine	cyclosporine	ADJ
admet-881	448	15	metabolism	metabolism	NOUN
admet-881	448	16	in	in	ADP
admet-881	448	17	human	human	ADJ
admet-881	448	18	liver	liver	NOUN
admet-881	448	19	:	:	PUNCT
admet-881	448	20	identification	identification	NOUN
admet-881	448	21	of	of	ADP
admet-881	448	22	a	a	DET
admet-881	448	23	cytochrome	cytochrome	NOUN
admet-881	448	24	p‐450iii	p‐450iii	NOUN
admet-881	448	25	gene	gene	NOUN
admet-881	448	26	family	family	NOUN
admet-881	448	27	as	as	ADP
admet-881	448	28	the	the	DET
admet-881	448	29	major	major	ADJ
admet-881	448	30	cyclosporine‐metabolizing	cyclosporine‐metabolize	VERB
admet-881	448	31	enzyme	enzyme	NOUN
admet-881	448	32	explains	explain	VERB
admet-881	448	33	interactions	interaction	NOUN
admet-881	448	34	of	of	ADP
admet-881	448	35	cyclosporine	cyclosporine	NOUN
admet-881	448	36	with	with	ADP
admet-881	448	37	other	other	ADJ
admet-881	448	38	drugs	drug	NOUN
admet-881	448	39	.	.	PUNCT
admet-881	449	1	clinical	clinical	ADJ
admet-881	449	2	pharmacology	pharmacology	NOUN
admet-881	449	3	and	and	CCONJ
admet-881	449	4	therapeutics	therapeutic	NOUN
admet-881	449	5	43	43	NUM
admet-881	449	6	(	(	PUNCT
admet-881	449	7	1988	1988	NUM
admet-881	449	8	)	)	PUNCT
admet-881	449	9	630635	630635	NUM
admet-881	449	10	.	.	PUNCT
admet-881	450	1	[	[	X
admet-881	450	2	69	69	NUM
admet-881	450	3	]	]	PUNCT
admet-881	450	4	a.	a.	PROPN
admet-881	450	5	munoz	munoz	PROPN
admet-881	450	6	,	,	PUNCT
admet-881	450	7	j.	j.	PROPN
admet-881	450	8	guichard	guichard	PROPN
admet-881	450	9	,	,	PUNCT
admet-881	450	10	p.	p.	NOUN
admet-881	450	11	reginault	reginault	NOUN
admet-881	450	12	.	.	PUNCT
admet-881	451	1	micronised	micronised	PROPN
admet-881	451	2	fenofibrate	fenofibrate	PROPN
admet-881	451	3	.	.	PUNCT
admet-881	452	1	atherosclerosis	atherosclerosis	NOUN
admet-881	452	2	110	110	NUM
admet-881	452	3	(	(	PUNCT
admet-881	452	4	1994	1994	NUM
admet-881	452	5	)	)	PUNCT
admet-881	452	6	s45	s45	NOUN
admet-881	452	7	-	-	PUNCT
admet-881	452	8	s48	s48	NOUN
admet-881	452	9	.	.	PUNCT
admet-881	453	1	[	[	X
admet-881	453	2	70	70	NUM
admet-881	453	3	]	]	X
admet-881	453	4	r.	r.	PROPN
admet-881	453	5	takano	takano	PROPN
admet-881	453	6	,	,	PUNCT
admet-881	453	7	k.	k.	PROPN
admet-881	453	8	furumoto	furumoto	PROPN
admet-881	453	9	,	,	PUNCT
admet-881	453	10	k.	k.	PROPN
admet-881	453	11	shiraki	shiraki	PROPN
admet-881	453	12	,	,	PUNCT
admet-881	453	13	n.	n.	NOUN
admet-881	453	14	takata	takata	NOUN
admet-881	453	15	,	,	PUNCT
admet-881	453	16	y.	y.	PROPN
admet-881	453	17	hayashi	hayashi	PROPN
admet-881	453	18	,	,	PUNCT
admet-881	453	19	y.	y.	PROPN
admet-881	453	20	aso	aso	PROPN
admet-881	453	21	,	,	PUNCT
admet-881	453	22	s.	s.	PROPN
admet-881	453	23	yamashita	yamashita	PROPN
admet-881	453	24	.	.	PUNCT
admet-881	454	1	rate	rate	NOUN
admet-881	454	2	-	-	PUNCT
admet-881	454	3	limiting	limit	VERB
admet-881	454	4	steps	step	NOUN
admet-881	454	5	of	of	ADP
admet-881	454	6	oral	oral	ADJ
admet-881	454	7	absorption	absorption	NOUN
admet-881	454	8	for	for	ADP
admet-881	454	9	poorly	poorly	ADV
admet-881	454	10	water	water	NOUN
admet-881	454	11	-	-	PUNCT
admet-881	454	12	soluble	soluble	ADJ
admet-881	454	13	drugs	drug	NOUN
admet-881	454	14	in	in	ADP
admet-881	454	15	dogs	dog	NOUN
admet-881	454	16	;	;	PUNCT
admet-881	454	17	prediction	prediction	NOUN
admet-881	454	18	from	from	ADP
admet-881	454	19	a	a	DET
admet-881	454	20	miniscale	miniscale	NOUN
admet-881	454	21	dissolution	dissolution	NOUN
admet-881	454	22	test	test	NOUN
admet-881	454	23	and	and	CCONJ
admet-881	454	24	a	a	DET
admet-881	454	25	physiologically	physiologically	ADV
admet-881	454	26	-	-	PUNCT
admet-881	454	27	based	base	VERB
admet-881	454	28	computer	computer	NOUN
admet-881	454	29	simulation	simulation	NOUN
admet-881	454	30	.	.	PUNCT
admet-881	455	1	pharmaceutical	pharmaceutical	PROPN
admet-881	455	2	research	research	NOUN
admet-881	455	3	25	25	NUM
admet-881	455	4	(	(	PUNCT
admet-881	455	5	2008	2008	NUM
admet-881	455	6	)	)	PUNCT
admet-881	455	7	2334	2334	NUM
admet-881	455	8	-	-	SYM
admet-881	455	9	2344	2344	NUM
admet-881	455	10	.	.	PUNCT
admet-881	456	1	[	[	X
admet-881	456	2	71	71	NUM
admet-881	456	3	]	]	X
admet-881	456	4	l.	l.	PROPN
admet-881	456	5	jia	jia	PROPN
admet-881	456	6	,	,	PUNCT
admet-881	456	7	h.	h.	PROPN
admet-881	456	8	wong	wong	PROPN
admet-881	456	9	,	,	PUNCT
admet-881	456	10	c.	c.	PROPN
admet-881	456	11	cerna	cerna	PROPN
admet-881	456	12	,	,	PUNCT
admet-881	456	13	s.d	s.d	PROPN
admet-881	456	14	.	.	PROPN
admet-881	456	15	weitman	weitman	PROPN
admet-881	456	16	.	.	PUNCT
admet-881	457	1	effect	effect	NOUN
admet-881	457	2	of	of	ADP
admet-881	457	3	nanonization	nanonization	NOUN
admet-881	457	4	on	on	ADP
admet-881	457	5	absorption	absorption	NOUN
admet-881	457	6	of	of	ADP
admet-881	457	7	301029	301029	NUM
admet-881	457	8	:	:	PUNCT
admet-881	457	9	ex	ex	PRON
admet-881	457	10	vivo	vivo	NOUN
admet-881	457	11	and	and	CCONJ
admet-881	457	12	in	in	ADP
admet-881	457	13	vivo	vivo	ADJ
admet-881	457	14	pharmacokinetic	pharmacokinetic	ADJ
admet-881	457	15	correlations	correlation	NOUN
admet-881	457	16	determined	determine	VERB
admet-881	457	17	by	by	ADP
admet-881	457	18	liquid	liquid	ADJ
admet-881	457	19	chromatography	chromatography	NOUN
admet-881	457	20	/	/	SYM
admet-881	457	21	mass	mass	NOUN
admet-881	457	22	spectrometry	spectrometry	NOUN
admet-881	457	23	.	.	PUNCT
admet-881	458	1	pharmaceutical	pharmaceutical	PROPN
admet-881	458	2	research	research	NOUN
admet-881	458	3	19	19	NUM
admet-881	458	4	(	(	PUNCT
admet-881	458	5	2002	2002	NUM
admet-881	458	6	)	)	PUNCT
admet-881	458	7	1091	1091	NUM
admet-881	458	8	-	-	SYM
admet-881	458	9	1096	1096	NUM
admet-881	458	10	.	.	PUNCT
admet-881	459	1	[	[	X
admet-881	459	2	72	72	NUM
admet-881	459	3	]	]	X
admet-881	459	4	y.	y.	NOUN
admet-881	459	5	shono	shono	PROPN
admet-881	459	6	,	,	PUNCT
admet-881	459	7	e.	e.	PROPN
admet-881	459	8	jantratid	jantratid	PROPN
admet-881	459	9	,	,	PUNCT
admet-881	459	10	f.	f.	PROPN
admet-881	459	11	kesisoglou	kesisoglou	PROPN
admet-881	459	12	,	,	PUNCT
admet-881	459	13	c.	c.	PROPN
admet-881	459	14	reppas	reppas	PROPN
admet-881	459	15	,	,	PUNCT
admet-881	459	16	j.b	j.b	PROPN
admet-881	459	17	.	.	PROPN
admet-881	459	18	dressman	dressman	PROPN
admet-881	459	19	.	.	PUNCT
admet-881	460	1	forecasting	forecasting	NOUN
admet-881	460	2	in	in	ADP
admet-881	460	3	vivo	vivo	ADJ
admet-881	460	4	oral	oral	ADJ
admet-881	460	5	absorption	absorption	NOUN
admet-881	460	6	and	and	CCONJ
admet-881	460	7	food	food	NOUN
admet-881	460	8	effect	effect	NOUN
admet-881	460	9	of	of	ADP
admet-881	460	10	micronized	micronized	ADJ
admet-881	460	11	and	and	CCONJ
admet-881	460	12	nanosized	nanosized	ADJ
admet-881	460	13	aprepitant	aprepitant	ADJ
admet-881	460	14	formulations	formulation	NOUN
admet-881	460	15	in	in	ADP
admet-881	460	16	humans	human	NOUN
admet-881	460	17	.	.	PUNCT
admet-881	461	1	european	european	ADJ
admet-881	461	2	journal	journal	PROPN
admet-881	461	3	of	of	ADP
admet-881	461	4	pharmaceutics	pharmaceutic	NOUN
admet-881	461	5	and	and	CCONJ
admet-881	461	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	461	7	76	76	NUM
admet-881	461	8	(	(	PUNCT
admet-881	461	9	2010	2010	NUM
admet-881	461	10	)	)	PUNCT
admet-881	461	11	95	95	NUM
admet-881	461	12	-	-	SYM
admet-881	461	13	104	104	NUM
admet-881	461	14	.	.	PUNCT
admet-881	462	1	[	[	X
admet-881	462	2	73	73	NUM
admet-881	462	3	]	]	X
admet-881	462	4	y.	y.	PROPN
admet-881	462	5	wu	wu	PROPN
admet-881	462	6	,	,	PUNCT
admet-881	462	7	a.	a.	PROPN
admet-881	462	8	loper	loper	PROPN
admet-881	462	9	,	,	PUNCT
admet-881	462	10	e.	e.	PROPN
admet-881	462	11	landis	landis	PROPN
admet-881	462	12	,	,	PUNCT
admet-881	462	13	l.	l.	PROPN
admet-881	462	14	hettrick	hettrick	PROPN
admet-881	462	15	,	,	PUNCT
admet-881	462	16	l.	l.	PROPN
admet-881	462	17	novak	novak	PROPN
admet-881	462	18	,	,	PUNCT
admet-881	462	19	k.	k.	PROPN
admet-881	462	20	lynn	lynn	PROPN
admet-881	462	21	,	,	PUNCT
admet-881	462	22	c.	c.	PROPN
admet-881	462	23	chen	chen	PROPN
admet-881	462	24	,	,	PUNCT
admet-881	462	25	k.	k.	PROPN
admet-881	462	26	thompson	thompson	PROPN
admet-881	462	27	,	,	PUNCT
admet-881	462	28	r.	r.	PROPN
admet-881	462	29	higgins	higgins	PROPN
admet-881	462	30	,	,	PUNCT
admet-881	462	31	u.	u.	PROPN
admet-881	462	32	batra	batra	PROPN
admet-881	462	33	.	.	PUNCT
admet-881	463	1	the	the	DET
admet-881	463	2	role	role	NOUN
admet-881	463	3	of	of	ADP
admet-881	463	4	biopharmaceutics	biopharmaceutics	NOUN
admet-881	463	5	in	in	ADP
admet-881	463	6	the	the	DET
admet-881	463	7	development	development	NOUN
admet-881	463	8	of	of	ADP
admet-881	463	9	a	a	DET
admet-881	463	10	clinical	clinical	ADJ
admet-881	463	11	nanoparticle	nanoparticle	NOUN
admet-881	463	12	formulation	formulation	NOUN
admet-881	463	13	of	of	ADP
admet-881	463	14	mk-0869	mk-0869	NOUN
admet-881	463	15	:	:	PUNCT
admet-881	463	16	a	a	DET
admet-881	463	17	beagle	beagle	NOUN
admet-881	463	18	dog	dog	NOUN
admet-881	463	19	model	model	NOUN
admet-881	463	20	predicts	predict	NOUN
admet-881	463	21	improved	improve	VERB
admet-881	463	22	bioavailability	bioavailability	NOUN
admet-881	463	23	and	and	CCONJ
admet-881	463	24	diminished	diminish	VERB
admet-881	463	25	food	food	NOUN
admet-881	463	26	effect	effect	NOUN
admet-881	463	27	on	on	ADP
admet-881	463	28	absorption	absorption	NOUN
admet-881	463	29	in	in	ADP
admet-881	463	30	human	human	PROPN
admet-881	463	31	.	.	PUNCT
admet-881	464	1	int	int	PROPN
admet-881	464	2	j	j	PROPN
admet-881	464	3	pharm	pharm	NOUN
admet-881	464	4	285	285	NUM
admet-881	464	5	(	(	PUNCT
admet-881	464	6	2004	2004	NUM
admet-881	464	7	)	)	PUNCT
admet-881	464	8	135	135	NUM
admet-881	464	9	-	-	SYM
admet-881	464	10	146	146	NUM
admet-881	464	11	.	.	PUNCT
admet-881	465	1	[	[	X
admet-881	465	2	74	74	NUM
admet-881	465	3	]	]	X
admet-881	465	4	a.k	a.k	PROPN
admet-881	465	5	.	.	PROPN
admet-881	465	6	majumdar	majumdar	PROPN
admet-881	465	7	,	,	PUNCT
admet-881	465	8	l.	l.	PROPN
admet-881	465	9	howard	howard	PROPN
admet-881	465	10	,	,	PUNCT
admet-881	465	11	m.r	m.r	PROPN
admet-881	465	12	.	.	PROPN
admet-881	465	13	goldberg	goldberg	PROPN
admet-881	465	14	,	,	PUNCT
admet-881	465	15	l.	l.	PROPN
admet-881	465	16	hickey	hickey	PROPN
admet-881	465	17	,	,	PUNCT
admet-881	465	18	m.	m.	NOUN
admet-881	465	19	constanzer	constanzer	PROPN
admet-881	465	20	,	,	PUNCT
admet-881	465	21	p.l	p.l	PROPN
admet-881	466	1	.	.	PROPN
admet-881	466	2	rothenberg	rothenberg	PROPN
admet-881	466	3	,	,	PUNCT
admet-881	466	4	t.m	t.m	PROPN
admet-881	466	5	.	.	PROPN
admet-881	466	6	crumley	crumley	PROPN
admet-881	466	7	,	,	PUNCT
admet-881	466	8	d.	d.	PROPN
admet-881	466	9	panebianco	panebianco	PROPN
admet-881	466	10	,	,	PUNCT
admet-881	466	11	t.e	t.e	PROPN
admet-881	466	12	.	.	PROPN
admet-881	466	13	bradstreet	bradstreet	PROPN
admet-881	466	14	,	,	PUNCT
admet-881	466	15	a.j	a.j	PROPN
admet-881	466	16	.	.	PROPN
admet-881	466	17	bergman	bergman	PROPN
admet-881	466	18	.	.	PUNCT
admet-881	467	1	pharmacokinetics	pharmacokinetic	NOUN
admet-881	467	2	of	of	ADP
admet-881	467	3	aprepitant	aprepitant	ADJ
admet-881	467	4	after	after	ADP
admet-881	467	5	single	single	ADJ
admet-881	467	6	and	and	CCONJ
admet-881	467	7	multiple	multiple	ADJ
admet-881	467	8	oral	oral	ADJ
admet-881	467	9	doses	dose	NOUN
admet-881	467	10	in	in	ADP
admet-881	467	11	healthy	healthy	ADJ
admet-881	467	12	volunteers	volunteer	NOUN
admet-881	467	13	.	.	PUNCT
admet-881	468	1	the	the	DET
admet-881	468	2	journal	journal	NOUN
admet-881	468	3	of	of	ADP
admet-881	468	4	clinical	clinical	ADJ
admet-881	468	5	pharmacology	pharmacology	NOUN
admet-881	468	6	46	46	NUM
admet-881	468	7	(	(	PUNCT
admet-881	468	8	2006	2006	NUM
admet-881	468	9	)	)	PUNCT
admet-881	468	10	291	291	NUM
admet-881	468	11	-	-	SYM
admet-881	468	12	300	300	NUM
admet-881	468	13	.	.	PUNCT
admet-881	469	1	[	[	X
admet-881	469	2	75	75	NUM
admet-881	469	3	]	]	X
admet-881	469	4	f.	f.	PROPN
admet-881	469	5	kesisoglou	kesisoglou	PROPN
admet-881	469	6	,	,	PUNCT
admet-881	469	7	s.	s.	PROPN
admet-881	469	8	panmai	panmai	PROPN
admet-881	469	9	,	,	PUNCT
admet-881	469	10	y.	y.	PROPN
admet-881	469	11	wu	wu	PROPN
admet-881	469	12	.	.	PUNCT
admet-881	470	1	nanosizing	nanosizing	NOUN
admet-881	470	2	—	—	PUNCT
admet-881	470	3	oral	oral	ADJ
admet-881	470	4	formulation	formulation	NOUN
admet-881	470	5	development	development	NOUN
admet-881	470	6	and	and	CCONJ
admet-881	470	7	biopharmaceutical	biopharmaceutical	NOUN
admet-881	470	8	evaluation	evaluation	NOUN
admet-881	470	9	.	.	PUNCT
admet-881	471	1	adv	adv	PROPN
admet-881	471	2	drug	drug	PROPN
admet-881	471	3	deliv	deliv	NOUN
admet-881	471	4	rev	rev	VERB
admet-881	471	5	59	59	NUM
admet-881	471	6	(	(	PUNCT
admet-881	471	7	2007	2007	NUM
admet-881	471	8	)	)	PUNCT
admet-881	471	9	631	631	NUM
admet-881	471	10	-	-	SYM
admet-881	471	11	644	644	NUM
admet-881	471	12	.	.	PUNCT
admet-881	472	1	[	[	X
admet-881	472	2	76	76	NUM
admet-881	472	3	]	]	X
admet-881	472	4	p.	p.	PROPN
admet-881	472	5	lundquist	lundquist	PROPN
admet-881	472	6	,	,	PUNCT
admet-881	472	7	p.	p.	PROPN
admet-881	472	8	artursson	artursson	PROPN
admet-881	472	9	.	.	PUNCT
admet-881	473	1	oral	oral	ADJ
admet-881	473	2	absorption	absorption	NOUN
admet-881	473	3	of	of	ADP
admet-881	473	4	peptides	peptide	NOUN
admet-881	473	5	and	and	CCONJ
admet-881	473	6	nanoparticles	nanoparticle	NOUN
admet-881	473	7	across	across	ADP
admet-881	473	8	the	the	DET
admet-881	473	9	human	human	ADJ
admet-881	473	10	intestine	intestine	NOUN
admet-881	473	11	:	:	PUNCT
admet-881	473	12	opportunities	opportunity	NOUN
admet-881	473	13	,	,	PUNCT
admet-881	473	14	limitations	limitation	NOUN
admet-881	473	15	and	and	CCONJ
admet-881	473	16	studies	study	NOUN
admet-881	473	17	in	in	ADP
admet-881	473	18	human	human	ADJ
admet-881	473	19	tissues	tissue	NOUN
admet-881	473	20	.	.	PUNCT
admet-881	474	1	advanced	advanced	ADJ
admet-881	474	2	drug	drug	NOUN
admet-881	474	3	delivery	delivery	NOUN
admet-881	474	4	reviews	review	NOUN
admet-881	474	5	106	106	NUM
admet-881	474	6	(	(	PUNCT
admet-881	474	7	2016	2016	NUM
admet-881	474	8	)	)	PUNCT
admet-881	474	9	256	256	NUM
admet-881	474	10	-	-	SYM
admet-881	474	11	276	276	NUM
admet-881	474	12	.	.	PUNCT
admet-881	475	1	https://dx.doi.org/10.5599/admet.881	https://dx.doi.org/10.5599/admet.881	ADJ
admet-881	475	2	h.	h.	PROPN
admet-881	475	3	lennernäs	lennernäs	PROPN
admet-881	475	4	et	et	PROPN
admet-881	475	5	al	al	PROPN
admet-881	475	6	.	.	PROPN
admet-881	475	7	admet	admet	PROPN
admet-881	475	8	&	&	CCONJ
admet-881	475	9	dmpk	dmpk	PROPN
admet-881	475	10	8(4	8(4	NOUN
admet-881	475	11	)	)	PUNCT
admet-881	475	12	(	(	PUNCT
admet-881	475	13	2020	2020	NUM
admet-881	475	14	)	)	PUNCT
admet-881	475	15	375	375	NUM
admet-881	475	16	-	-	SYM
admet-881	475	17	390	390	NUM
admet-881	475	18	390	390	NUM
admet-881	476	1	[	[	X
admet-881	476	2	77	77	NUM
admet-881	476	3	]	]	X
admet-881	476	4	s.m	s.m	PROPN
admet-881	476	5	.	.	PROPN
admet-881	476	6	sharpe	sharpe	PROPN
admet-881	476	7	,	,	PUNCT
admet-881	476	8	x.	x.	PROPN
admet-881	476	9	qin	qin	PROPN
admet-881	476	10	,	,	PUNCT
admet-881	476	11	q.	q.	PROPN
admet-881	476	12	lu	lu	PROPN
admet-881	476	13	,	,	PUNCT
admet-881	476	14	e.	e.	PROPN
admet-881	476	15	feketeova	feketeova	PROPN
admet-881	476	16	,	,	PUNCT
admet-881	476	17	d.c	d.c	PROPN
admet-881	476	18	.	.	PROPN
admet-881	476	19	palange	palange	PROPN
admet-881	476	20	,	,	PUNCT
admet-881	476	21	w.	w.	PROPN
admet-881	476	22	dong	dong	PROPN
admet-881	476	23	,	,	PUNCT
admet-881	476	24	s.u	s.u	PROPN
admet-881	476	25	.	.	PROPN
admet-881	476	26	sheth	sheth	PROPN
admet-881	476	27	,	,	PUNCT
admet-881	476	28	m.a	m.a	PROPN
admet-881	476	29	.	.	PROPN
admet-881	476	30	lee	lee	PROPN
admet-881	476	31	,	,	PUNCT
admet-881	476	32	d.	d.	PROPN
admet-881	476	33	reino	reino	PROPN
admet-881	476	34	,	,	PUNCT
admet-881	476	35	d.-z	d.-z	PROPN
admet-881	476	36	.	.	PUNCT
admet-881	477	1	xu	xu	INTJ
admet-881	477	2	.	.	PUNCT
admet-881	478	1	loss	loss	NOUN
admet-881	478	2	of	of	ADP
admet-881	478	3	the	the	DET
admet-881	478	4	intestinal	intestinal	ADJ
admet-881	478	5	mucus	mucus	NOUN
admet-881	478	6	layer	layer	NOUN
admet-881	478	7	in	in	ADP
admet-881	478	8	the	the	DET
admet-881	478	9	normal	normal	ADJ
admet-881	478	10	rat	rat	NOUN
admet-881	478	11	causes	cause	VERB
admet-881	478	12	gut	gut	NOUN
admet-881	478	13	injury	injury	NOUN
admet-881	478	14	,	,	PUNCT
admet-881	478	15	but	but	CCONJ
admet-881	478	16	not	not	PART
admet-881	478	17	toxic	toxic	ADJ
admet-881	478	18	mesenteric	mesenteric	ADJ
admet-881	478	19	lymph	lymph	NOUN
admet-881	478	20	nor	nor	CCONJ
admet-881	478	21	lung	lung	NOUN
admet-881	478	22	injury	injury	NOUN
admet-881	478	23	.	.	PUNCT
admet-881	479	1	shock	shock	NOUN
admet-881	479	2	(	(	PUNCT
admet-881	479	3	augusta	augusta	PROPN
admet-881	479	4	,	,	PUNCT
admet-881	479	5	ga	ga	PROPN
admet-881	479	6	.	.	PROPN
admet-881	479	7	)	)	PUNCT
admet-881	480	1	34	34	NUM
admet-881	480	2	(	(	PUNCT
admet-881	480	3	2010	2010	NUM
admet-881	480	4	)	)	PUNCT
admet-881	480	5	475	475	NUM
admet-881	480	6	.	.	PUNCT
admet-881	481	1	[	[	X
admet-881	481	2	78	78	NUM
admet-881	481	3	]	]	X
admet-881	481	4	c.	c.	NOUN
admet-881	481	5	roos	roos	PROPN
admet-881	481	6	,	,	PUNCT
admet-881	481	7	d.	d.	PROPN
admet-881	481	8	dahlgren	dahlgren	PROPN
admet-881	481	9	,	,	PUNCT
admet-881	481	10	e.	e.	PROPN
admet-881	481	11	sjögren	sjögren	PROPN
admet-881	481	12	,	,	PUNCT
admet-881	481	13	m.	m.	NOUN
admet-881	481	14	sjöblom	sjöblom	PROPN
admet-881	481	15	,	,	PUNCT
admet-881	481	16	m.	m.	PROPN
admet-881	481	17	hedeland	hedeland	PROPN
admet-881	481	18	,	,	PUNCT
admet-881	481	19	h.	h.	PROPN
admet-881	481	20	lennernäs	lennernäs	PROPN
admet-881	481	21	.	.	PUNCT
admet-881	482	1	jejunal	jejunal	ADJ
admet-881	482	2	absorption	absorption	NOUN
admet-881	482	3	of	of	ADP
admet-881	482	4	aprepitant	aprepitant	ADJ
admet-881	482	5	from	from	ADP
admet-881	482	6	nanosuspensions	nanosuspension	NOUN
admet-881	482	7	:	:	PUNCT
admet-881	482	8	role	role	NOUN
admet-881	482	9	of	of	ADP
admet-881	482	10	particle	particle	NOUN
admet-881	482	11	size	size	NOUN
admet-881	482	12	,	,	PUNCT
admet-881	482	13	prandial	prandial	ADJ
admet-881	482	14	state	state	NOUN
admet-881	482	15	and	and	CCONJ
admet-881	482	16	mucus	mucus	NOUN
admet-881	482	17	layer	layer	NOUN
admet-881	482	18	.	.	PUNCT
admet-881	483	1	european	european	PROPN
admet-881	483	2	journal	journal	PROPN
admet-881	483	3	of	of	ADP
admet-881	483	4	pharmaceutics	pharmaceutic	NOUN
admet-881	483	5	and	and	CCONJ
admet-881	483	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	483	7	132	132	NUM
admet-881	483	8	(	(	PUNCT
admet-881	483	9	2018	2018	NUM
admet-881	483	10	)	)	PUNCT
admet-881	483	11	222	222	NUM
admet-881	483	12	-	-	SYM
admet-881	483	13	230	230	NUM
admet-881	483	14	.	.	PUNCT
admet-881	484	1	[	[	X
admet-881	484	2	79	79	NUM
admet-881	484	3	]	]	PUNCT
admet-881	484	4	y.-y	y.-y	NOUN
admet-881	484	5	.	.	PUNCT
admet-881	485	1	chiu	chiu	PROPN
admet-881	485	2	,	,	PUNCT
admet-881	485	3	k.	k.	PROPN
admet-881	485	4	higaki	higaki	PROPN
admet-881	485	5	,	,	PUNCT
admet-881	485	6	b.l	b.l	PROPN
admet-881	485	7	.	.	PROPN
admet-881	485	8	neudeck	neudeck	PROPN
admet-881	485	9	,	,	PUNCT
admet-881	485	10	j.l	j.l	PROPN
admet-881	485	11	.	.	PROPN
admet-881	485	12	barnett	barnett	PROPN
admet-881	485	13	,	,	PUNCT
admet-881	485	14	l.s	l.s	PROPN
admet-881	485	15	.	.	PROPN
admet-881	485	16	welage	welage	NOUN
admet-881	485	17	,	,	PUNCT
admet-881	485	18	g.l	g.l	PROPN
admet-881	485	19	.	.	PROPN
admet-881	485	20	amidon	amidon	PROPN
admet-881	485	21	.	.	PUNCT
admet-881	486	1	human	human	ADJ
admet-881	486	2	jejunal	jejunal	ADJ
admet-881	486	3	permeability	permeability	NOUN
admet-881	486	4	of	of	ADP
admet-881	486	5	cyclosporin	cyclosporin	NOUN
admet-881	486	6	a	a	DET
admet-881	486	7	:	:	PUNCT
admet-881	486	8	influence	influence	NOUN
admet-881	486	9	of	of	ADP
admet-881	486	10	surfactants	surfactant	NOUN
admet-881	486	11	on	on	ADP
admet-881	486	12	p	p	NOUN
admet-881	486	13	-	-	PUNCT
admet-881	486	14	glycoprotein	glycoprotein	NOUN
admet-881	486	15	efflux	efflux	NOUN
admet-881	486	16	in	in	ADP
admet-881	486	17	caco-2	caco-2	NUM
admet-881	486	18	cells	cell	NOUN
admet-881	486	19	.	.	PUNCT
admet-881	487	1	pharmaceutical	pharmaceutical	ADJ
admet-881	487	2	research	research	NOUN
admet-881	487	3	20	20	NUM
admet-881	487	4	(	(	PUNCT
admet-881	487	5	2003	2003	NUM
admet-881	487	6	)	)	PUNCT
admet-881	487	7	749	749	NUM
admet-881	487	8	-	-	SYM
admet-881	487	9	756	756	NUM
admet-881	487	10	.	.	PUNCT
admet-881	488	1	[	[	X
admet-881	488	2	80	80	NUM
admet-881	488	3	]	]	X
admet-881	488	4	h.	h.	PROPN
admet-881	488	5	lennernas	lennernas	PROPN
admet-881	488	6	.	.	PUNCT
admet-881	489	1	intestinal	intestinal	ADJ
admet-881	489	2	permeability	permeability	NOUN
admet-881	489	3	and	and	CCONJ
admet-881	489	4	its	its	PRON
admet-881	489	5	relevance	relevance	NOUN
admet-881	489	6	for	for	ADP
admet-881	489	7	absorption	absorption	NOUN
admet-881	489	8	and	and	CCONJ
admet-881	489	9	elimination	elimination	NOUN
admet-881	489	10	.	.	PUNCT
admet-881	490	1	xenobiotica	xenobiotica	PROPN
admet-881	490	2	37	37	NUM
admet-881	490	3	(	(	PUNCT
admet-881	490	4	2007	2007	NUM
admet-881	490	5	)	)	PUNCT
admet-881	490	6	1015	1015	NUM
admet-881	490	7	-	-	SYM
admet-881	490	8	1051	1051	NUM
admet-881	490	9	.	.	PUNCT
admet-881	491	1	[	[	X
admet-881	491	2	81	81	NUM
admet-881	491	3	]	]	PUNCT
admet-881	491	4	c.	c.	PROPN
admet-881	491	5	roos	roos	PROPN
admet-881	491	6	,	,	PUNCT
admet-881	491	7	j.	j.	PROPN
admet-881	491	8	westergren	westergren	PROPN
admet-881	491	9	,	,	PUNCT
admet-881	491	10	d.	d.	PROPN
admet-881	491	11	dahlgren	dahlgren	PROPN
admet-881	491	12	,	,	PUNCT
admet-881	491	13	h.	h.	PROPN
admet-881	491	14	lennernäs	lennernäs	PROPN
admet-881	491	15	,	,	PUNCT
admet-881	491	16	e.	e.	PROPN
admet-881	491	17	sjögren	sjögren	PROPN
admet-881	491	18	.	.	PUNCT
admet-881	492	1	mechanistic	mechanistic	ADJ
admet-881	492	2	modelling	modelling	NOUN
admet-881	492	3	of	of	ADP
admet-881	492	4	intestinal	intestinal	ADJ
admet-881	492	5	drug	drug	NOUN
admet-881	492	6	absorption	absorption	NOUN
admet-881	492	7	–	–	PUNCT
admet-881	492	8	the	the	PRON
admet-881	492	9	in	in	ADP
admet-881	492	10	vivo	vivo	ADJ
admet-881	492	11	effects	effect	NOUN
admet-881	492	12	of	of	ADP
admet-881	492	13	nanoparticles	nanoparticle	NOUN
admet-881	492	14	,	,	PUNCT
admet-881	492	15	hydrodynamics	hydrodynamic	NOUN
admet-881	492	16	,	,	PUNCT
admet-881	492	17	and	and	CCONJ
admet-881	492	18	colloidal	colloidal	NOUN
admet-881	492	19	structures	structure	NOUN
admet-881	492	20	.	.	PUNCT
admet-881	493	1	european	european	ADJ
admet-881	493	2	journal	journal	PROPN
admet-881	493	3	of	of	ADP
admet-881	493	4	pharmaceutics	pharmaceutic	NOUN
admet-881	493	5	and	and	CCONJ
admet-881	493	6	biopharmaceutics	biopharmaceutic	NOUN
admet-881	493	7	133	133	NUM
admet-881	493	8	(	(	PUNCT
admet-881	493	9	2018	2018	NUM
admet-881	493	10	)	)	PUNCT
admet-881	493	11	70	70	NUM
admet-881	493	12	-	-	SYM
admet-881	493	13	76	76	NUM
admet-881	493	14	.	.	PUNCT
admet-881	494	1	[	[	X
admet-881	494	2	82	82	NUM
admet-881	494	3	]	]	PUNCT
admet-881	494	4	t.	t.	NOUN
admet-881	494	5	heimbach	heimbach	NOUN
admet-881	494	6	,	,	PUNCT
admet-881	494	7	s.	s.	PROPN
admet-881	494	8	suarez	suarez	PROPN
admet-881	494	9	-	-	PUNCT
admet-881	494	10	sharp	sharp	ADJ
admet-881	494	11	,	,	PUNCT
admet-881	494	12	m.	m.	NOUN
admet-881	494	13	kakhi	kakhi	PROPN
admet-881	494	14	,	,	PUNCT
admet-881	494	15	n.	n.	NOUN
admet-881	494	16	holmstock	holmstock	NOUN
admet-881	494	17	,	,	PUNCT
admet-881	494	18	a.	a.	NOUN
admet-881	494	19	olivares	olivare	NOUN
admet-881	494	20	-	-	PUNCT
admet-881	494	21	morales	morale	NOUN
admet-881	494	22	,	,	PUNCT
admet-881	494	23	x.	x.	NOUN
admet-881	494	24	pepin	pepin	PROPN
admet-881	494	25	,	,	PUNCT
admet-881	494	26	e.	e.	PROPN
admet-881	494	27	sjögren	sjögren	PROPN
admet-881	494	28	,	,	PUNCT
admet-881	494	29	e.	e.	PROPN
admet-881	494	30	tsakalozou	tsakalozou	PROPN
admet-881	494	31	,	,	PUNCT
admet-881	494	32	p.	p.	PROPN
admet-881	494	33	seo	seo	PROPN
admet-881	494	34	,	,	PUNCT
admet-881	494	35	m.	m.	PROPN
admet-881	494	36	li	li	PROPN
admet-881	494	37	.	.	PROPN
admet-881	494	38	dissolution	dissolution	PROPN
admet-881	494	39	and	and	CCONJ
admet-881	494	40	translational	translational	ADJ
admet-881	494	41	modeling	modeling	NOUN
admet-881	494	42	strategies	strategy	NOUN
admet-881	494	43	toward	toward	ADP
admet-881	494	44	establishing	establish	VERB
admet-881	494	45	an	an	DET
admet-881	494	46	in	in	X
admet-881	494	47	vitro	vitro	NOUN
admet-881	494	48	-	-	PUNCT
admet-881	494	49	in	in	ADP
admet-881	494	50	vivo	vivo	NOUN
admet-881	494	51	link	link	NOUN
admet-881	494	52	—	—	PUNCT
admet-881	494	53	a	a	DET
admet-881	494	54	workshop	workshop	NOUN
admet-881	494	55	summary	summary	NOUN
admet-881	494	56	report	report	NOUN
admet-881	494	57	.	.	PUNCT
admet-881	495	1	springer	springer	NOUN
admet-881	495	2	,	,	PUNCT
admet-881	495	3	2019	2019	NUM
admet-881	495	4	.	.	PUNCT
admet-881	496	1	[	[	X
admet-881	496	2	83	83	NUM
admet-881	496	3	]	]	X
admet-881	496	4	h.	h.	PROPN
admet-881	496	5	lennernäs	lennernäs	PROPN
admet-881	496	6	,	,	PUNCT
admet-881	496	7	c.-g	c.-g	PROPN
admet-881	496	8	.	.	PUNCT
admet-881	497	1	regårdh	regårdh	NOUN
admet-881	497	2	.	.	PUNCT
admet-881	498	1	evidence	evidence	NOUN
admet-881	498	2	for	for	ADP
admet-881	498	3	an	an	DET
admet-881	498	4	interaction	interaction	NOUN
admet-881	498	5	between	between	ADP
admet-881	498	6	the	the	DET
admet-881	498	7	β	β	NOUN
admet-881	498	8	-	-	NOUN
admet-881	498	9	blocker	blocker	NOUN
admet-881	498	10	pafenolol	pafenolol	NOUN
admet-881	498	11	and	and	CCONJ
admet-881	498	12	bile	bile	NOUN
admet-881	498	13	salts	salt	NOUN
admet-881	498	14	in	in	ADP
admet-881	498	15	the	the	DET
admet-881	498	16	intestinal	intestinal	ADJ
admet-881	498	17	lumen	luman	NOUN
admet-881	498	18	of	of	ADP
admet-881	498	19	the	the	DET
admet-881	498	20	rat	rat	NOUN
admet-881	498	21	leading	lead	VERB
admet-881	498	22	to	to	ADP
admet-881	498	23	dose	dose	NOUN
admet-881	498	24	-	-	PUNCT
admet-881	498	25	dependent	dependent	ADJ
admet-881	498	26	oral	oral	ADJ
admet-881	498	27	absorption	absorption	NOUN
admet-881	498	28	and	and	CCONJ
admet-881	498	29	double	double	ADJ
admet-881	498	30	peaks	peak	NOUN
admet-881	498	31	in	in	ADP
admet-881	498	32	the	the	DET
admet-881	498	33	plasma	plasma	NOUN
admet-881	498	34	concentration	concentration	NOUN
admet-881	498	35	–	–	PUNCT
admet-881	498	36	time	time	NOUN
admet-881	498	37	profile	profile	NOUN
admet-881	498	38	.	.	PUNCT
admet-881	499	1	pharmaceutical	pharmaceutical	ADJ
admet-881	499	2	research	research	NOUN
admet-881	499	3	10	10	NUM
admet-881	499	4	(	(	PUNCT
admet-881	499	5	1993	1993	NUM
admet-881	499	6	)	)	PUNCT
admet-881	499	7	879	879	NUM
admet-881	499	8	-	-	SYM
admet-881	499	9	883	883	NUM
admet-881	499	10	.	.	PUNCT
admet-881	500	1	[	[	X
admet-881	500	2	84	84	NUM
admet-881	500	3	]	]	X
admet-881	500	4	c.	c.	PROPN
admet-881	500	5	regårdh	regårdh	PROPN
admet-881	500	6	,	,	PUNCT
admet-881	500	7	a.	a.	NOUN
admet-881	500	8	heggelund	heggelund	PROPN
admet-881	500	9	,	,	PUNCT
admet-881	500	10	k.	k.	PROPN
admet-881	500	11	kylberg‐hanssen	kylberg‐hanssen	PROPN
admet-881	500	12	,	,	PUNCT
admet-881	500	13	p.	p.	NOUN
admet-881	500	14	lundborg	lundborg	PROPN
admet-881	500	15	.	.	PUNCT
admet-881	501	1	pharmacokinetics	pharmacokinetic	NOUN
admet-881	501	2	of	of	ADP
admet-881	501	3	pafenolol	pafenolol	NOUN
admet-881	501	4	after	after	ADP
admet-881	501	5	iv	iv	ADP
admet-881	501	6	and	and	CCONJ
admet-881	501	7	oral	oral	ADJ
admet-881	501	8	administration	administration	NOUN
admet-881	501	9	of	of	ADP
admet-881	501	10	three	three	NUM
admet-881	501	11	separate	separate	ADJ
admet-881	501	12	doses	dose	NOUN
admet-881	501	13	of	of	ADP
admet-881	501	14	different	different	ADJ
admet-881	501	15	strength	strength	NOUN
admet-881	501	16	to	to	ADP
admet-881	501	17	man	man	NOUN
admet-881	501	18	.	.	PUNCT
admet-881	502	1	biopharmaceutics	biopharmaceutics	NOUN
admet-881	502	2	and	and	CCONJ
admet-881	502	3	drug	drug	NOUN
admet-881	502	4	disposition	disposition	NOUN
admet-881	502	5	11	11	NUM
admet-881	502	6	(	(	PUNCT
admet-881	502	7	1990	1990	NUM
admet-881	502	8	)	)	PUNCT
admet-881	502	9	607	607	NUM
admet-881	502	10	-	-	SYM
admet-881	502	11	617	617	NUM
admet-881	502	12	.	.	PUNCT
admet-881	503	1	[	[	X
admet-881	503	2	85	85	NUM
admet-881	503	3	]	]	PUNCT
admet-881	503	4	t.	t.	PROPN
admet-881	503	5	zhu	zhu	PROPN
admet-881	503	6	,	,	PUNCT
admet-881	503	7	j.c	j.c	PROPN
admet-881	503	8	.	.	PROPN
admet-881	503	9	ansquer	ansquer	PROPN
admet-881	503	10	,	,	PUNCT
admet-881	503	11	m.t	m.t	PROPN
admet-881	503	12	.	.	PROPN
admet-881	503	13	kelly	kelly	PROPN
admet-881	503	14	,	,	PUNCT
admet-881	503	15	d.j	d.j	PROPN
admet-881	503	16	.	.	PROPN
admet-881	503	17	sleep	sleep	PROPN
admet-881	503	18	,	,	PUNCT
admet-881	503	19	r.s	r.s	PROPN
admet-881	503	20	.	.	PROPN
admet-881	503	21	pradhan	pradhan	PROPN
admet-881	503	22	.	.	PUNCT
admet-881	504	1	comparison	comparison	NOUN
admet-881	504	2	of	of	ADP
admet-881	504	3	the	the	DET
admet-881	504	4	gastrointestinal	gastrointestinal	ADJ
admet-881	504	5	absorption	absorption	NOUN
admet-881	504	6	and	and	CCONJ
admet-881	504	7	bioavailability	bioavailability	NOUN
admet-881	504	8	of	of	ADP
admet-881	504	9	fenofibrate	fenofibrate	NOUN
admet-881	504	10	and	and	CCONJ
admet-881	504	11	fenofibric	fenofibric	NOUN
admet-881	504	12	acid	acid	NOUN
admet-881	504	13	in	in	ADP
admet-881	504	14	humans	human	NOUN
admet-881	504	15	.	.	PUNCT
admet-881	505	1	the	the	DET
admet-881	505	2	journal	journal	NOUN
admet-881	505	3	of	of	ADP
admet-881	505	4	clinical	clinical	ADJ
admet-881	505	5	pharmacology	pharmacology	NOUN
admet-881	505	6	50	50	NUM
admet-881	505	7	(	(	PUNCT
admet-881	505	8	2010	2010	NUM
admet-881	505	9	)	)	PUNCT
admet-881	505	10	914	914	NUM
admet-881	505	11	-	-	SYM
admet-881	505	12	921	921	NUM
admet-881	505	13	.	.	PUNCT
admet-881	506	1	[	[	X
admet-881	506	2	86	86	NUM
admet-881	506	3	]	]	PUNCT
admet-881	506	4	a.m.	a.m.	PROPN
admet-881	506	5	yousaf	yousaf	PROPN
admet-881	506	6	,	,	PUNCT
admet-881	506	7	d.w	d.w	PROPN
admet-881	506	8	.	.	PROPN
admet-881	506	9	kim	kim	PROPN
admet-881	506	10	,	,	PUNCT
admet-881	506	11	y.-k	y.-k	PROPN
admet-881	506	12	.	.	PUNCT
admet-881	507	1	oh	oh	INTJ
admet-881	507	2	,	,	PUNCT
admet-881	507	3	c.s	c.s	PROPN
admet-881	507	4	.	.	PROPN
admet-881	507	5	yong	yong	PROPN
admet-881	507	6	,	,	PUNCT
admet-881	507	7	j.o	j.o	PROPN
admet-881	507	8	.	.	PROPN
admet-881	507	9	kim	kim	PROPN
admet-881	507	10	,	,	PUNCT
admet-881	507	11	h.-g	h.-g	PROPN
admet-881	507	12	.	.	PUNCT
admet-881	508	1	choi	choi	PROPN
admet-881	508	2	.	.	PUNCT
admet-881	509	1	enhanced	enhance	VERB
admet-881	509	2	oral	oral	ADJ
admet-881	509	3	bioavailability	bioavailability	NOUN
admet-881	509	4	of	of	ADP
admet-881	509	5	fenofibrate	fenofibrate	NOUN
admet-881	509	6	using	use	VERB
admet-881	509	7	polymeric	polymeric	ADJ
admet-881	509	8	nanoparticulated	nanoparticulate	VERB
admet-881	509	9	systems	system	NOUN
admet-881	509	10	:	:	PUNCT
admet-881	509	11	physicochemical	physicochemical	ADJ
admet-881	509	12	characterization	characterization	NOUN
admet-881	509	13	and	and	CCONJ
admet-881	509	14	in	in	ADP
admet-881	509	15	vivo	vivo	ADJ
admet-881	509	16	investigation	investigation	NOUN
admet-881	509	17	.	.	PUNCT
admet-881	510	1	international	international	ADJ
admet-881	510	2	journal	journal	NOUN
admet-881	510	3	of	of	ADP
admet-881	510	4	nanomedicine	nanomedicine	NOUN
admet-881	510	5	10	10	NUM
admet-881	510	6	(	(	PUNCT
admet-881	510	7	2015	2015	NUM
admet-881	510	8	)	)	PUNCT
admet-881	510	9	1819	1819	NUM
admet-881	510	10	.	.	PUNCT
admet-881	511	1	[	[	X
admet-881	511	2	87	87	NUM
admet-881	511	3	]	]	PUNCT
admet-881	511	4	b.	b.	PROPN
admet-881	511	5	borgström	borgström	PROPN
admet-881	511	6	.	.	PUNCT
admet-881	512	1	studies	study	NOUN
admet-881	512	2	on	on	ADP
admet-881	512	3	intestinal	intestinal	ADJ
admet-881	512	4	cholesterol	cholesterol	NOUN
admet-881	512	5	absorption	absorption	NOUN
admet-881	512	6	in	in	ADP
admet-881	512	7	the	the	DET
admet-881	512	8	human	human	NOUN
admet-881	512	9	.	.	PUNCT
admet-881	513	1	the	the	DET
admet-881	513	2	journal	journal	NOUN
admet-881	513	3	of	of	ADP
admet-881	513	4	clinical	clinical	ADJ
admet-881	513	5	investigation	investigation	NOUN
admet-881	513	6	39	39	NUM
admet-881	513	7	(	(	PUNCT
admet-881	513	8	1960	1960	NUM
admet-881	513	9	)	)	PUNCT
admet-881	513	10	809	809	NUM
admet-881	513	11	-	-	SYM
admet-881	513	12	815	815	NUM
admet-881	513	13	.	.	PUNCT
admet-881	514	1	[	[	X
admet-881	514	2	88	88	NUM
admet-881	514	3	]	]	X
admet-881	514	4	d.	d.	PROPN
admet-881	514	5	nyholm	nyholm	PROPN
admet-881	514	6	,	,	PUNCT
admet-881	514	7	a.	a.	PROPN
admet-881	514	8	johansson	johansson	PROPN
admet-881	514	9	,	,	PUNCT
admet-881	514	10	s.-m	s.-m	PROPN
admet-881	514	11	.	.	PUNCT
admet-881	515	1	aquilonius	aquilonius	PROPN
admet-881	515	2	,	,	PUNCT
admet-881	515	3	e.	e.	PROPN
admet-881	515	4	hellquist	hellquist	PROPN
admet-881	515	5	,	,	PUNCT
admet-881	515	6	h.	h.	PROPN
admet-881	515	7	lennernäs	lennernäs	PROPN
admet-881	515	8	,	,	PUNCT
admet-881	515	9	h.	h.	PROPN
admet-881	515	10	askmark	askmark	PROPN
admet-881	515	11	.	.	PUNCT
admet-881	516	1	complexity	complexity	NOUN
admet-881	516	2	of	of	ADP
admet-881	516	3	motor	motor	NOUN
admet-881	516	4	response	response	NOUN
admet-881	516	5	to	to	ADP
admet-881	516	6	different	different	ADJ
admet-881	516	7	doses	dose	NOUN
admet-881	516	8	of	of	ADP
admet-881	516	9	duodenal	duodenal	ADJ
admet-881	516	10	levodopa	levodopa	NOUN
admet-881	516	11	infusion	infusion	NOUN
admet-881	516	12	in	in	ADP
admet-881	516	13	parkinson	parkinson	NOUN
admet-881	516	14	disease	disease	NOUN
admet-881	516	15	.	.	PUNCT
admet-881	517	1	clinical	clinical	ADJ
admet-881	517	2	neuropharmacology	neuropharmacology	NOUN
admet-881	517	3	35	35	NUM
admet-881	517	4	(	(	PUNCT
admet-881	517	5	2012	2012	NUM
admet-881	517	6	)	)	PUNCT
admet-881	517	7	6	6	NUM
admet-881	517	8	-	-	SYM
admet-881	517	9	14	14	NUM
admet-881	517	10	.	.	PUNCT
admet-881	518	1	[	[	X
admet-881	518	2	89	89	NUM
admet-881	518	3	]	]	X
admet-881	518	4	d.	d.	PROPN
admet-881	518	5	nyholm	nyholm	PROPN
admet-881	518	6	,	,	PUNCT
admet-881	518	7	h.	h.	PROPN
admet-881	518	8	askmark	askmark	PROPN
admet-881	518	9	,	,	PUNCT
admet-881	518	10	c.	c.	PROPN
admet-881	518	11	gomes	gome	NOUN
admet-881	518	12	–	–	PUNCT
admet-881	518	13	trolin	trolin	NOUN
admet-881	518	14	,	,	PUNCT
admet-881	518	15	t.	t.	PROPN
admet-881	518	16	knutson	knutson	PROPN
admet-881	518	17	,	,	PUNCT
admet-881	518	18	h.	h.	PROPN
admet-881	518	19	lennernäs	lennernäs	PROPN
admet-881	518	20	,	,	PUNCT
admet-881	518	21	c.	c.	PROPN
admet-881	518	22	nyström	nyström	PROPN
admet-881	518	23	,	,	PUNCT
admet-881	518	24	s.-m	s.-m	PROPN
admet-881	518	25	.	.	PUNCT
admet-881	519	1	aquilonius	aquilonius	NOUN
admet-881	519	2	.	.	PUNCT
admet-881	520	1	optimizing	optimize	VERB
admet-881	520	2	levodopa	levodopa	NOUN
admet-881	520	3	pharmacokinetics	pharmacokinetic	NOUN
admet-881	520	4	:	:	PUNCT
admet-881	520	5	intestinal	intestinal	ADJ
admet-881	520	6	infusion	infusion	NOUN
admet-881	520	7	versus	versus	ADP
admet-881	520	8	oral	oral	ADJ
admet-881	520	9	sustained	sustain	VERB
admet-881	520	10	-	-	PUNCT
admet-881	520	11	release	release	NOUN
admet-881	520	12	tablets	tablet	NOUN
admet-881	520	13	.	.	PUNCT
admet-881	521	1	clinical	clinical	ADJ
admet-881	521	2	neuropharmacology	neuropharmacology	NOUN
admet-881	521	3	26	26	NUM
admet-881	521	4	(	(	PUNCT
admet-881	521	5	2003	2003	NUM
admet-881	521	6	)	)	PUNCT
admet-881	521	7	156	156	NUM
admet-881	521	8	-	-	SYM
admet-881	521	9	163	163	NUM
admet-881	521	10	.	.	PUNCT
admet-881	522	1	[	[	X
admet-881	522	2	90	90	NUM
admet-881	522	3	]	]	X
admet-881	522	4	d.	d.	PROPN
admet-881	522	5	fleisher	fleisher	PROPN
admet-881	522	6	,	,	PUNCT
admet-881	522	7	c.	c.	PROPN
admet-881	522	8	li	li	PROPN
admet-881	522	9	,	,	PUNCT
admet-881	522	10	y.	y.	PROPN
admet-881	522	11	zhou	zhou	PROPN
admet-881	522	12	,	,	PUNCT
admet-881	522	13	l.-h	l.-h	PROPN
admet-881	522	14	.	.	PUNCT
admet-881	523	1	pao	pao	PROPN
admet-881	523	2	,	,	PUNCT
admet-881	523	3	a.	a.	PROPN
admet-881	523	4	karim	karim	PROPN
admet-881	523	5	.	.	PUNCT
admet-881	524	1	drug	drug	NOUN
admet-881	524	2	,	,	PUNCT
admet-881	524	3	meal	meal	NOUN
admet-881	524	4	and	and	CCONJ
admet-881	524	5	formulation	formulation	NOUN
admet-881	524	6	interactions	interaction	NOUN
admet-881	524	7	influencing	influence	VERB
admet-881	524	8	drug	drug	NOUN
admet-881	524	9	absorption	absorption	NOUN
admet-881	524	10	after	after	ADP
admet-881	524	11	oral	oral	ADJ
admet-881	524	12	administration	administration	NOUN
admet-881	524	13	.	.	PUNCT
admet-881	525	1	clinical	clinical	ADJ
admet-881	525	2	pharmacokinetics	pharmacokinetic	NOUN
admet-881	525	3	36	36	NUM
admet-881	525	4	(	(	PUNCT
admet-881	525	5	1999	1999	NUM
admet-881	525	6	)	)	PUNCT
admet-881	525	7	233	233	NUM
admet-881	525	8	-	-	SYM
admet-881	525	9	254	254	NUM
admet-881	525	10	.	.	PUNCT
admet-881	526	1	©	©	PROPN
admet-881	526	2	2020	2020	NUM
admet-881	526	3	by	by	ADP
admet-881	526	4	the	the	DET
admet-881	526	5	authors	author	NOUN
admet-881	526	6	;	;	PUNCT
admet-881	526	7	licensee	licensee	PROPN
admet-881	526	8	iapc	iapc	PROPN
admet-881	526	9	,	,	PUNCT
admet-881	526	10	zagreb	zagreb	PROPN
admet-881	526	11	,	,	PUNCT
admet-881	526	12	croatia	croatia	PROPN
admet-881	526	13	.	.	PUNCT
admet-881	527	1	this	this	DET
admet-881	527	2	article	article	NOUN
admet-881	527	3	is	be	AUX
admet-881	527	4	an	an	DET
admet-881	527	5	open	open	ADJ
admet-881	527	6	-	-	PUNCT
admet-881	527	7	access	access	NOUN
admet-881	527	8	article	article	NOUN
admet-881	527	9	distributed	distribute	VERB
admet-881	527	10	under	under	ADP
admet-881	527	11	the	the	DET
admet-881	527	12	terms	term	NOUN
admet-881	527	13	and	and	CCONJ
admet-881	527	14	conditions	condition	NOUN
admet-881	527	15	of	of	ADP
admet-881	527	16	the	the	DET
admet-881	527	17	creative	creative	ADJ
admet-881	527	18	commons	common	NOUN
admet-881	527	19	attribution	attribution	NOUN
admet-881	527	20	license	license	NOUN
admet-881	527	21	(	(	PUNCT
admet-881	527	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-881	527	23	)	)	PUNCT
admet-881	527	24	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN