id	sid	tid	token	lemma	pos
admet-882	1	1	permeability	permeability	NOUN
admet-882	1	2	evaluation	evaluation	NOUN
admet-882	1	3	of	of	ADP
admet-882	1	4	gemcitabine	gemcitabine	NOUN
admet-882	1	5	-	-	PUNCT
admet-882	1	6	cpp6	cpp6	NOUN
admet-882	1	7	conjugates	conjugate	NOUN
admet-882	1	8	in	in	ADP
admet-882	1	9	caco-2	caco-2	NUM
admet-882	1	10	cells	cell	NOUN
admet-882	1	11	doi	doi	NOUN
admet-882	1	12	:	:	PUNCT
admet-882	1	13	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	1	14	41	41	NUM
admet-882	1	15	admet	admet	PROPN
admet-882	1	16	&	&	CCONJ
admet-882	1	17	dmpk	dmpk	PROPN
admet-882	1	18	9(1	9(1	NUM
admet-882	1	19	)	)	PUNCT
admet-882	1	20	(	(	PUNCT
admet-882	1	21	2021	2021	NUM
admet-882	1	22	)	)	PUNCT
admet-882	1	23	41	41	NUM
admet-882	1	24	-	-	SYM
admet-882	1	25	48	48	NUM
admet-882	1	26	;	;	PUNCT
admet-882	1	27	doi	doi	NOUN
admet-882	1	28	:	:	PUNCT
admet-882	1	29	https://dx.doi.org/10.5599/admet.882	https://dx.doi.org/10.5599/admet.882	X
admet-882	1	30	open	open	ADJ
admet-882	1	31	access	access	NOUN
admet-882	1	32	:	:	PUNCT
admet-882	1	33	issn	issn	PROPN
admet-882	1	34	:	:	PUNCT
admet-882	1	35	1848	1848	NUM
admet-882	1	36	-	-	SYM
admet-882	1	37	7718	7718	NUM
admet-882	1	38	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	NOUN
admet-882	1	39	original	original	ADJ
admet-882	1	40	scientific	scientific	ADJ
admet-882	1	41	paper	paper	NOUN
admet-882	1	42	permeability	permeability	NOUN
admet-882	1	43	evaluation	evaluation	NOUN
admet-882	1	44	of	of	ADP
admet-882	1	45	gemcitabine	gemcitabine	NOUN
admet-882	1	46	-	-	PUNCT
admet-882	1	47	cpp6	cpp6	NOUN
admet-882	1	48	conjugates	conjugate	NOUN
admet-882	1	49	in	in	ADP
admet-882	1	50	caco-2	caco-2	NUM
admet-882	1	51	cells	cell	NOUN
admet-882	1	52	abigail	abigail	NOUN
admet-882	1	53	ferreira1,2	ferreira1,2	PROPN
admet-882	1	54	,	,	PUNCT
admet-882	1	55	sara	sara	PROPN
admet-882	1	56	moreira1,3	moreira1,3	PROPN
admet-882	1	57	,	,	PUNCT
admet-882	1	58	rui	rui	PROPN
admet-882	1	59	lapa2	lapa2	PROPN
admet-882	1	60	and	and	CCONJ
admet-882	1	61	nuno	nuno	PROPN
admet-882	1	62	vale1,4	vale1,4	PROPN
admet-882	1	63	*	*	PROPN
admet-882	1	64	1	1	NUM
admet-882	1	65	oncopharma	oncopharma	NOUN
admet-882	1	66	research	research	NOUN
admet-882	1	67	group	group	NOUN
admet-882	1	68	,	,	PUNCT
admet-882	1	69	center	center	NOUN
admet-882	1	70	for	for	ADP
admet-882	1	71	health	health	NOUN
admet-882	1	72	technology	technology	NOUN
admet-882	1	73	and	and	CCONJ
admet-882	1	74	services	service	NOUN
admet-882	1	75	research	research	NOUN
admet-882	1	76	(	(	PUNCT
admet-882	1	77	cintesis	cintesis	NOUN
admet-882	1	78	)	)	PUNCT
admet-882	1	79	,	,	PUNCT
admet-882	1	80	rua	rua	PROPN
admet-882	1	81	dr	dr	PROPN
admet-882	1	82	.	.	PROPN
admet-882	1	83	plácido	plácido	PROPN
admet-882	1	84	da	da	PROPN
admet-882	1	85	costa	costa	PROPN
admet-882	1	86	,	,	PUNCT
admet-882	1	87	4200	4200	NUM
admet-882	1	88	-	-	SYM
admet-882	1	89	450	450	NUM
admet-882	1	90	porto	porto	NOUN
admet-882	1	91	,	,	PUNCT
admet-882	1	92	portugal	portugal	PROPN
admet-882	1	93	2	2	NUM
admet-882	1	94	laqv	laqv	NOUN
admet-882	1	95	/	/	SYM
admet-882	1	96	requimte	requimte	NOUN
admet-882	1	97	,	,	PUNCT
admet-882	1	98	laboratory	laboratory	NOUN
admet-882	1	99	of	of	ADP
admet-882	1	100	applied	apply	VERB
admet-882	1	101	chemistry	chemistry	NOUN
admet-882	1	102	,	,	PUNCT
admet-882	1	103	department	department	NOUN
admet-882	1	104	of	of	ADP
admet-882	1	105	chemical	chemical	PROPN
admet-882	1	106	sciences	sciences	PROPN
admet-882	1	107	,	,	PUNCT
admet-882	1	108	faculty	faculty	NOUN
admet-882	1	109	of	of	ADP
admet-882	1	110	pharmacy	pharmacy	NOUN
admet-882	1	111	,	,	PUNCT
admet-882	1	112	university	university	NOUN
admet-882	1	113	of	of	ADP
admet-882	1	114	porto	porto	PROPN
admet-882	1	115	,	,	PUNCT
admet-882	1	116	rua	rua	PROPN
admet-882	1	117	de	de	PROPN
admet-882	1	118	jorge	jorge	PROPN
admet-882	1	119	viterbo	viterbo	PROPN
admet-882	1	120	ferreira	ferreira	PROPN
admet-882	1	121	,	,	PUNCT
admet-882	1	122	228	228	NUM
admet-882	1	123	,	,	PUNCT
admet-882	1	124	4050	4050	NUM
admet-882	1	125	-	-	SYM
admet-882	1	126	313	313	NUM
admet-882	1	127	porto	porto	PROPN
admet-882	1	128	,	,	PUNCT
admet-882	1	129	portugal	portugal	PROPN
admet-882	1	130	3	3	NUM
admet-882	1	131	faculty	faculty	NOUN
admet-882	1	132	of	of	ADP
admet-882	1	133	sciences	science	NOUN
admet-882	1	134	,	,	PUNCT
admet-882	1	135	university	university	NOUN
admet-882	1	136	of	of	ADP
admet-882	1	137	porto	porto	PROPN
admet-882	1	138	,	,	PUNCT
admet-882	1	139	rua	rua	PROPN
admet-882	1	140	do	do	AUX
admet-882	1	141	campo	campo	PROPN
admet-882	1	142	alegre	alegre	PROPN
admet-882	1	143	,	,	PUNCT
admet-882	1	144	687	687	NUM
admet-882	1	145	,	,	PUNCT
admet-882	1	146	4169	4169	NUM
admet-882	1	147	-	-	SYM
admet-882	1	148	007	007	NUM
admet-882	1	149	porto	porto	PROPN
admet-882	1	150	,	,	PUNCT
admet-882	1	151	portugal	portugal	PROPN
admet-882	1	152	4	4	NUM
admet-882	1	153	faculty	faculty	NOUN
admet-882	1	154	of	of	ADP
admet-882	1	155	medicine	medicine	NOUN
admet-882	1	156	,	,	PUNCT
admet-882	1	157	university	university	NOUN
admet-882	1	158	of	of	ADP
admet-882	1	159	porto	porto	PROPN
admet-882	1	160	,	,	PUNCT
admet-882	1	161	al	al	PROPN
admet-882	1	162	.	.	PROPN
admet-882	1	163	prof	prof	PROPN
admet-882	1	164	.	.	PROPN
admet-882	1	165	hernâni	hernâni	PROPN
admet-882	1	166	monteiro	monteiro	PROPN
admet-882	1	167	,	,	PUNCT
admet-882	1	168	4200	4200	NUM
admet-882	1	169	-	-	SYM
admet-882	1	170	319	319	NUM
admet-882	1	171	porto	porto	NOUN
admet-882	1	172	,	,	PUNCT
admet-882	1	173	portugal	portugal	PROPN
admet-882	1	174	*	*	SYM
admet-882	1	175	corresponding	correspond	VERB
admet-882	1	176	author	author	NOUN
admet-882	1	177	:	:	PUNCT
admet-882	2	1	e	e	NOUN
admet-882	2	2	-	-	NOUN
admet-882	2	3	mail	mail	NOUN
admet-882	2	4	:	:	PUNCT
admet-882	2	5	nunovale@med.up.pt	nunovale@med.up.pt	NOUN
admet-882	2	6	;	;	PUNCT
admet-882	2	7	tel	tel	PROPN
admet-882	2	8	.	.	PUNCT
admet-882	2	9	:	:	PUNCT
admet-882	3	1	+351	+351	X
admet-882	3	2	-	-	SYM
admet-882	3	3	225513600	225513600	NUM
admet-882	3	4	;	;	PUNCT
admet-882	3	5	fax	fax	NOUN
admet-882	3	6	:	:	PUNCT
admet-882	3	7	+351	+351	NUM
admet-882	3	8	-	-	SYM
admet-882	3	9	225513601	225513601	NUM
admet-882	3	10	received	receive	VERB
admet-882	3	11	:	:	PUNCT
admet-882	3	12	july	july	PROPN
admet-882	3	13	04	04	NUM
admet-882	3	14	,	,	PUNCT
admet-882	3	15	2020	2020	NUM
admet-882	3	16	;	;	PUNCT
admet-882	3	17	revised	revise	VERB
admet-882	3	18	:	:	PUNCT
admet-882	3	19	october	october	PROPN
admet-882	3	20	13	13	NUM
admet-882	3	21	,	,	PUNCT
admet-882	3	22	2020	2020	NUM
admet-882	3	23	;	;	PUNCT
admet-882	3	24	published	publish	VERB
admet-882	3	25	:	:	PUNCT
admet-882	3	26	october	october	PROPN
admet-882	3	27	26	26	NUM
admet-882	3	28	,	,	PUNCT
admet-882	3	29	2020	2020	NUM
admet-882	3	30	abstract	abstract	ADJ
admet-882	3	31	cancer	cancer	NOUN
admet-882	3	32	is	be	AUX
admet-882	3	33	one	one	NUM
admet-882	3	34	of	of	ADP
admet-882	3	35	the	the	DET
admet-882	3	36	most	most	ADV
admet-882	3	37	alarming	alarming	ADJ
admet-882	3	38	diseases	disease	NOUN
admet-882	3	39	due	due	ADP
admet-882	3	40	to	to	ADP
admet-882	3	41	its	its	PRON
admet-882	3	42	high	high	ADJ
admet-882	3	43	mortality	mortality	NOUN
admet-882	3	44	and	and	CCONJ
admet-882	3	45	still	still	ADV
admet-882	3	46	increasing	increase	VERB
admet-882	3	47	incidence	incidence	NOUN
admet-882	3	48	rate	rate	NOUN
admet-882	3	49	.	.	PUNCT
admet-882	4	1	currently	currently	ADV
admet-882	4	2	available	available	ADJ
admet-882	4	3	treatments	treatment	NOUN
admet-882	4	4	for	for	ADP
admet-882	4	5	this	this	DET
admet-882	4	6	condition	condition	NOUN
admet-882	4	7	present	present	VERB
admet-882	4	8	several	several	ADJ
admet-882	4	9	shortcomings	shortcoming	NOUN
admet-882	4	10	and	and	CCONJ
admet-882	4	11	new	new	ADJ
admet-882	4	12	options	option	NOUN
admet-882	4	13	are	be	AUX
admet-882	4	14	continuously	continuously	ADV
admet-882	4	15	being	be	AUX
admet-882	4	16	developed	develop	VERB
admet-882	4	17	and	and	CCONJ
admet-882	4	18	evaluated	evaluate	VERB
admet-882	4	19	,	,	PUNCT
admet-882	4	20	aiming	aim	VERB
admet-882	4	21	at	at	ADP
admet-882	4	22	increasing	increase	VERB
admet-882	4	23	the	the	DET
admet-882	4	24	overall	overall	ADJ
admet-882	4	25	treatment	treatment	NOUN
admet-882	4	26	efficiency	efficiency	NOUN
admet-882	4	27	and	and	CCONJ
admet-882	4	28	reducing	reduce	VERB
admet-882	4	29	associated	associate	VERB
admet-882	4	30	adverse	adverse	ADJ
admet-882	4	31	side	side	NOUN
admet-882	4	32	effects	effect	NOUN
admet-882	4	33	.	.	PUNCT
admet-882	5	1	gemcitabine	gemcitabine	NOUN
admet-882	5	2	has	have	AUX
admet-882	5	3	proven	prove	VERB
admet-882	5	4	activity	activity	NOUN
admet-882	5	5	and	and	CCONJ
admet-882	5	6	is	be	AUX
admet-882	5	7	used	use	VERB
admet-882	5	8	in	in	ADP
admet-882	5	9	chemotherapy	chemotherapy	NOUN
admet-882	5	10	.	.	PUNCT
admet-882	6	1	however	however	ADV
admet-882	6	2	,	,	PUNCT
admet-882	6	3	its	its	PRON
admet-882	6	4	therapeutic	therapeutic	ADJ
admet-882	6	5	efficiency	efficiency	NOUN
admet-882	6	6	is	be	AUX
admet-882	6	7	limited	limit	VERB
admet-882	6	8	by	by	ADP
admet-882	6	9	its	its	PRON
admet-882	6	10	low	low	ADJ
admet-882	6	11	bioavailability	bioavailability	NOUN
admet-882	6	12	as	as	ADP
admet-882	6	13	a	a	DET
admet-882	6	14	result	result	NOUN
admet-882	6	15	of	of	ADP
admet-882	6	16	rapid	rapid	ADJ
admet-882	6	17	enzymatic	enzymatic	ADJ
admet-882	6	18	inactivation	inactivation	NOUN
admet-882	6	19	.	.	PUNCT
admet-882	7	1	additionally	additionally	ADV
admet-882	7	2	,	,	PUNCT
admet-882	7	3	tumor	tumor	NOUN
admet-882	7	4	cells	cell	NOUN
admet-882	7	5	often	often	ADV
admet-882	7	6	develop	develop	VERB
admet-882	7	7	drug	drug	NOUN
admet-882	7	8	resistance	resistance	NOUN
admet-882	7	9	after	after	ADP
admet-882	7	10	initial	initial	ADJ
admet-882	7	11	tumor	tumor	NOUN
admet-882	7	12	regression	regression	NOUN
admet-882	7	13	related	relate	VERB
admet-882	7	14	to	to	ADP
admet-882	7	15	transporter	transporter	NOUN
admet-882	7	16	deficiency	deficiency	NOUN
admet-882	7	17	.	.	PUNCT
admet-882	8	1	we	we	PRON
admet-882	8	2	have	have	AUX
admet-882	8	3	previously	previously	ADV
admet-882	8	4	developed	develop	VERB
admet-882	8	5	three	three	NUM
admet-882	8	6	gemcitabine	gemcitabine	NOUN
admet-882	8	7	conjugates	conjugate	NOUN
admet-882	8	8	with	with	ADP
admet-882	8	9	cellpenetrating	cellpenetrate	VERB
admet-882	8	10	hexapeptides	hexapeptide	NOUN
admet-882	8	11	(	(	PUNCT
admet-882	8	12	cpp6	cpp6	PROPN
admet-882	8	13	)	)	PUNCT
admet-882	8	14	to	to	PART
admet-882	8	15	facilitate	facilitate	VERB
admet-882	8	16	intracellular	intracellular	ADJ
admet-882	8	17	delivery	delivery	NOUN
admet-882	8	18	of	of	ADP
admet-882	8	19	this	this	DET
admet-882	8	20	drug	drug	NOUN
admet-882	8	21	while	while	SCONJ
admet-882	8	22	also	also	ADV
admet-882	8	23	preventing	prevent	VERB
admet-882	8	24	enzymatic	enzymatic	ADJ
admet-882	8	25	deamination	deamination	NOUN
admet-882	8	26	.	.	PUNCT
admet-882	9	1	the	the	DET
admet-882	9	2	bioactivity	bioactivity	NOUN
admet-882	9	3	of	of	ADP
admet-882	9	4	these	these	DET
admet-882	9	5	new	new	ADJ
admet-882	9	6	prodrugs	prodrug	NOUN
admet-882	9	7	was	be	AUX
admet-882	9	8	evaluated	evaluate	VERB
admet-882	9	9	in	in	ADP
admet-882	9	10	different	different	ADJ
admet-882	9	11	cell	cell	NOUN
admet-882	9	12	lines	line	NOUN
admet-882	9	13	and	and	CCONJ
admet-882	9	14	showed	show	VERB
admet-882	9	15	promising	promising	ADJ
admet-882	9	16	results	result	NOUN
admet-882	9	17	.	.	PUNCT
admet-882	10	1	here	here	ADV
admet-882	10	2	,	,	PUNCT
admet-882	10	3	we	we	PRON
admet-882	10	4	assessed	assess	VERB
admet-882	10	5	the	the	DET
admet-882	10	6	absorption	absorption	NOUN
admet-882	10	7	and	and	CCONJ
admet-882	10	8	permeability	permeability	NOUN
admet-882	10	9	across	across	ADP
admet-882	10	10	caco-2	caco-2	NUM
admet-882	10	11	monolayers	monolayer	NOUN
admet-882	10	12	of	of	ADP
admet-882	10	13	these	these	DET
admet-882	10	14	conjugates	conjugate	NOUN
admet-882	10	15	in	in	ADP
admet-882	10	16	comparison	comparison	NOUN
admet-882	10	17	with	with	ADP
admet-882	10	18	gemcitabine	gemcitabine	NOUN
admet-882	10	19	and	and	CCONJ
admet-882	10	20	the	the	DET
admet-882	10	21	respective	respective	ADJ
admet-882	10	22	isolated	isolated	ADJ
admet-882	10	23	cell	cell	NOUN
admet-882	10	24	-	-	PUNCT
admet-882	10	25	penetrating	penetrate	VERB
admet-882	10	26	peptides	peptide	NOUN
admet-882	10	27	(	(	PUNCT
admet-882	10	28	cpps	cpps	PROPN
admet-882	10	29	)	)	PUNCT
admet-882	10	30	.	.	PUNCT
admet-882	11	1	cpp6	cpp6	PROPN
admet-882	11	2	-	-	PUNCT
admet-882	11	3	2	2	NUM
admet-882	11	4	(	(	PUNCT
admet-882	11	5	klpvmw	klpvmw	PROPN
admet-882	11	6	)	)	PUNCT
admet-882	11	7	and	and	CCONJ
admet-882	11	8	respective	respective	ADJ
admet-882	11	9	gem	gem	NOUN
admet-882	11	10	-	-	PUNCT
admet-882	11	11	cpp6	cpp6	NOUN
admet-882	11	12	-	-	PUNCT
admet-882	11	13	2	2	NUM
admet-882	11	14	conjugate	conjugate	NOUN
admet-882	11	15	showed	show	VERB
admet-882	11	16	the	the	DET
admet-882	11	17	highest	high	ADJ
admet-882	11	18	permeability	permeability	NOUN
admet-882	11	19	in	in	ADP
admet-882	11	20	caco2	caco2	NOUN
admet-882	11	21	cells	cell	NOUN
admet-882	11	22	.	.	PUNCT
admet-882	12	1	©	©	PROPN
admet-882	12	2	2021	2021	NUM
admet-882	12	3	by	by	ADP
admet-882	12	4	the	the	DET
admet-882	12	5	authors	author	NOUN
admet-882	12	6	.	.	PUNCT
admet-882	13	1	this	this	DET
admet-882	13	2	article	article	NOUN
admet-882	13	3	is	be	AUX
admet-882	13	4	an	an	DET
admet-882	13	5	open	open	ADJ
admet-882	13	6	-	-	PUNCT
admet-882	13	7	access	access	NOUN
admet-882	13	8	article	article	NOUN
admet-882	13	9	distributed	distribute	VERB
admet-882	13	10	under	under	ADP
admet-882	13	11	the	the	DET
admet-882	13	12	terms	term	NOUN
admet-882	13	13	and	and	CCONJ
admet-882	13	14	conditions	condition	NOUN
admet-882	13	15	of	of	ADP
admet-882	13	16	the	the	DET
admet-882	13	17	creative	creative	ADJ
admet-882	13	18	commons	common	NOUN
admet-882	13	19	attribution	attribution	NOUN
admet-882	13	20	license	license	NOUN
admet-882	13	21	(	(	PUNCT
admet-882	13	22	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-882	13	23	)	)	PUNCT
admet-882	13	24	.	.	PUNCT
admet-882	14	1	keywords	keyword	VERB
admet-882	14	2	cell	cell	NOUN
admet-882	14	3	-	-	PUNCT
admet-882	14	4	penetrating	penetrate	VERB
admet-882	14	5	peptides	peptide	NOUN
admet-882	14	6	;	;	PUNCT
admet-882	14	7	permeability	permeability	NOUN
admet-882	14	8	;	;	PUNCT
admet-882	14	9	solubility	solubility	NOUN
admet-882	14	10	;	;	PUNCT
admet-882	14	11	caco-2	caco-2	NUM
admet-882	14	12	;	;	PUNCT
admet-882	14	13	dmpk	dmpk	NOUN
admet-882	14	14	.	.	PUNCT
admet-882	15	1	introduction	introduction	NOUN
admet-882	15	2	cancer	cancer	NOUN
admet-882	15	3	is	be	AUX
admet-882	15	4	the	the	DET
admet-882	15	5	second	second	ADJ
admet-882	15	6	leading	leading	ADJ
admet-882	15	7	cause	cause	NOUN
admet-882	15	8	of	of	ADP
admet-882	15	9	death	death	NOUN
admet-882	15	10	worldwide	worldwide	ADV
admet-882	15	11	.	.	PUNCT
admet-882	16	1	there	there	PRON
admet-882	16	2	were	be	VERB
admet-882	16	3	18	18	NUM
admet-882	16	4	million	million	NUM
admet-882	16	5	new	new	ADJ
admet-882	16	6	cases	case	NOUN
admet-882	16	7	and	and	CCONJ
admet-882	16	8	9.6	9.6	NUM
admet-882	16	9	million	million	NUM
admet-882	16	10	cancer	cancer	NOUN
admet-882	16	11	related	relate	VERB
admet-882	16	12	deaths	death	NOUN
admet-882	16	13	in	in	ADP
admet-882	16	14	2018	2018	NUM
admet-882	16	15	.	.	PUNCT
admet-882	17	1	globally	globally	ADV
admet-882	17	2	,	,	PUNCT
admet-882	17	3	about	about	ADV
admet-882	17	4	one	one	NUM
admet-882	17	5	in	in	ADP
admet-882	17	6	six	six	NUM
admet-882	17	7	deaths	death	NOUN
admet-882	17	8	is	be	AUX
admet-882	17	9	due	due	ADJ
admet-882	17	10	to	to	ADP
admet-882	17	11	cancer	cancer	NOUN
admet-882	17	12	.	.	PUNCT
admet-882	18	1	lung	lung	NOUN
admet-882	18	2	and	and	CCONJ
admet-882	18	3	prostate	prostate	NOUN
admet-882	18	4	cancers	cancer	NOUN
admet-882	18	5	are	be	AUX
admet-882	18	6	the	the	DET
admet-882	18	7	most	most	ADV
admet-882	18	8	prevalent	prevalent	ADJ
admet-882	18	9	in	in	ADP
admet-882	18	10	men	man	NOUN
admet-882	18	11	,	,	PUNCT
admet-882	18	12	while	while	SCONJ
admet-882	18	13	breast	breast	NOUN
admet-882	18	14	and	and	CCONJ
admet-882	18	15	colorectum	colorectum	NOUN
admet-882	18	16	cancers	cancer	NOUN
admet-882	18	17	affect	affect	VERB
admet-882	18	18	women	woman	NOUN
admet-882	18	19	the	the	DET
admet-882	18	20	most	most	ADV
admet-882	18	21	[	[	X
admet-882	18	22	1	1	NUM
admet-882	18	23	]	]	PUNCT
admet-882	18	24	.	.	PUNCT
admet-882	19	1	drug	drug	NOUN
admet-882	19	2	resistance	resistance	NOUN
admet-882	19	3	and	and	CCONJ
admet-882	19	4	overall	overall	ADJ
admet-882	19	5	treatment	treatment	NOUN
admet-882	19	6	inefficacy	inefficacy	NOUN
admet-882	19	7	are	be	AUX
admet-882	19	8	responsible	responsible	ADJ
admet-882	19	9	for	for	ADP
admet-882	19	10	the	the	DET
admet-882	19	11	high	high	ADJ
admet-882	19	12	mortality	mortality	NOUN
admet-882	19	13	of	of	ADP
admet-882	19	14	this	this	DET
admet-882	19	15	multifactorial	multifactorial	ADJ
admet-882	19	16	disease	disease	NOUN
admet-882	19	17	.	.	PUNCT
admet-882	20	1	difficulty	difficulty	NOUN
admet-882	20	2	in	in	ADP
admet-882	20	3	recognizing	recognize	VERB
admet-882	20	4	altered	altered	ADJ
admet-882	20	5	cells	cell	NOUN
admet-882	20	6	and	and	CCONJ
admet-882	20	7	distinguishing	distinguish	VERB
admet-882	20	8	them	they	PRON
admet-882	20	9	from	from	ADP
admet-882	20	10	normal	normal	ADJ
admet-882	20	11	cells	cell	NOUN
admet-882	20	12	as	as	ADV
admet-882	20	13	well	well	ADV
admet-882	20	14	as	as	ADP
admet-882	20	15	reaching	reach	VERB
admet-882	20	16	metastases	metastasis	NOUN
admet-882	20	17	are	be	AUX
admet-882	20	18	the	the	DET
admet-882	20	19	main	main	ADJ
admet-882	20	20	hurdles	hurdle	NOUN
admet-882	20	21	of	of	ADP
admet-882	20	22	cancer	cancer	NOUN
admet-882	20	23	therapy	therapy	NOUN
admet-882	20	24	.	.	PUNCT
admet-882	21	1	research	research	NOUN
admet-882	21	2	in	in	ADP
admet-882	21	3	this	this	DET
admet-882	21	4	field	field	NOUN
admet-882	21	5	strives	strive	VERB
admet-882	21	6	to	to	PART
admet-882	21	7	maximize	maximize	VERB
admet-882	21	8	efficacy	efficacy	NOUN
admet-882	21	9	while	while	SCONJ
admet-882	21	10	reducing	reduce	VERB
admet-882	21	11	adverse	adverse	ADJ
admet-882	21	12	side	side	NOUN
admet-882	21	13	effects	effect	NOUN
admet-882	21	14	.	.	PUNCT
admet-882	22	1	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	22	2	https://dx.doi.org/10.5599/admet.882	https://dx.doi.org/10.5599/admet.882	PUNCT
admet-882	23	1	http://www.pub.iapchem.org/ojs/index.php/admet/index	http://www.pub.iapchem.org/ojs/index.php/admet/index	PROPN
admet-882	23	2	mailto:nunovale@med.up.pt	mailto:nunovale@med.up.pt	PROPN
admet-882	23	3	http://creativecommons.org/licenses/by/4.0/	http://creativecommons.org/licenses/by/4.0/	PROPN
admet-882	23	4	n.	n.	PROPN
admet-882	23	5	vale	vale	PROPN
admet-882	23	6	et	et	PROPN
admet-882	23	7	al	al	PROPN
admet-882	23	8	.	.	PROPN
admet-882	23	9	admet	admet	PROPN
admet-882	23	10	&	&	CCONJ
admet-882	23	11	dmpk	dmpk	PROPN
admet-882	23	12	9(1	9(1	NUM
admet-882	23	13	)	)	PUNCT
admet-882	23	14	(	(	PUNCT
admet-882	23	15	2021	2021	NUM
admet-882	23	16	)	)	PUNCT
admet-882	23	17	41	41	NUM
admet-882	23	18	-	-	SYM
admet-882	23	19	48	48	NUM
admet-882	23	20	42	42	NUM
admet-882	23	21	gemcitabine	gemcitabine	NOUN
admet-882	23	22	(	(	PUNCT
admet-882	23	23	gem	gem	NOUN
admet-882	23	24	,	,	PUNCT
admet-882	23	25	dfdc	dfdc	ADJ
admet-882	23	26	or	or	CCONJ
admet-882	23	27	2′,2′-difluoro-2′-deoxycytidine	2′,2′-difluoro-2′-deoxycytidine	NUM
admet-882	23	28	,	,	PUNCT
admet-882	23	29	scheme	scheme	NOUN
admet-882	23	30	1	1	NUM
admet-882	23	31	)	)	PUNCT
admet-882	23	32	is	be	AUX
admet-882	23	33	a	a	DET
admet-882	23	34	cytotoxic	cytotoxic	ADJ
admet-882	23	35	nucleoside	nucleoside	NOUN
admet-882	23	36	analogue	analogue	NOUN
admet-882	23	37	used	use	VERB
admet-882	23	38	as	as	ADP
admet-882	23	39	a	a	DET
admet-882	23	40	chemotherapeutic	chemotherapeutic	ADJ
admet-882	23	41	drug	drug	NOUN
admet-882	23	42	.	.	PUNCT
admet-882	24	1	it	it	PRON
admet-882	24	2	is	be	AUX
admet-882	24	3	effective	effective	ADJ
admet-882	24	4	against	against	ADP
admet-882	24	5	an	an	DET
admet-882	24	6	extensive	extensive	ADJ
admet-882	24	7	range	range	NOUN
admet-882	24	8	of	of	ADP
admet-882	24	9	solid	solid	ADJ
admet-882	24	10	tumors	tumor	NOUN
admet-882	24	11	,	,	PUNCT
admet-882	24	12	such	such	ADJ
admet-882	24	13	as	as	ADP
admet-882	24	14	pancreatic	pancreatic	ADJ
admet-882	24	15	,	,	PUNCT
admet-882	24	16	non	non	ADJ
admet-882	24	17	-	-	ADJ
admet-882	24	18	small	small	ADJ
admet-882	24	19	cell	cell	NOUN
admet-882	24	20	lung	lung	NOUN
admet-882	24	21	,	,	PUNCT
admet-882	24	22	breast	breast	NOUN
admet-882	24	23	and	and	CCONJ
admet-882	24	24	ovarian	ovarian	ADJ
admet-882	24	25	cancers	cancer	NOUN
admet-882	24	26	,	,	PUNCT
admet-882	24	27	and	and	CCONJ
admet-882	24	28	is	be	AUX
admet-882	24	29	often	often	ADV
admet-882	24	30	a	a	DET
admet-882	24	31	first	first	ADJ
admet-882	24	32	-	-	PUNCT
admet-882	24	33	line	line	NOUN
admet-882	24	34	treatment	treatment	NOUN
admet-882	24	35	in	in	ADP
admet-882	24	36	clinical	clinical	ADJ
admet-882	24	37	settings	setting	NOUN
admet-882	24	38	[	[	X
admet-882	24	39	2	2	NUM
admet-882	24	40	]	]	PUNCT
admet-882	24	41	.	.	PUNCT
admet-882	25	1	despite	despite	SCONJ
admet-882	25	2	being	be	AUX
admet-882	25	3	administered	administer	VERB
admet-882	25	4	intravenously	intravenously	ADV
admet-882	25	5	,	,	PUNCT
admet-882	25	6	treatment	treatment	NOUN
admet-882	25	7	with	with	ADP
admet-882	25	8	gemcitabine	gemcitabine	NOUN
admet-882	25	9	has	have	AUX
admet-882	25	10	limited	limit	VERB
admet-882	25	11	efficacy	efficacy	NOUN
admet-882	25	12	largely	largely	ADV
admet-882	25	13	due	due	ADP
admet-882	25	14	to	to	ADP
admet-882	25	15	its	its	PRON
admet-882	25	16	short	short	ADJ
admet-882	25	17	half	half	ADJ
admet-882	25	18	-	-	PUNCT
admet-882	25	19	life	life	NOUN
admet-882	25	20	(	(	PUNCT
admet-882	25	21	8	8	NUM
admet-882	25	22	-	-	SYM
admet-882	25	23	17	17	NUM
admet-882	25	24	min	min	NOUN
admet-882	25	25	)	)	PUNCT
admet-882	25	26	,	,	PUNCT
admet-882	25	27	since	since	SCONJ
admet-882	25	28	gemcitabine	gemcitabine	NOUN
admet-882	25	29	is	be	AUX
admet-882	25	30	rapidly	rapidly	ADV
admet-882	25	31	inactivated	inactivate	VERB
admet-882	25	32	metabolically	metabolically	NOUN
admet-882	25	33	in	in	ADP
admet-882	25	34	the	the	DET
admet-882	25	35	serum	serum	NOUN
admet-882	25	36	through	through	ADP
admet-882	25	37	deamination	deamination	NOUN
admet-882	25	38	of	of	ADP
admet-882	25	39	its	its	PRON
admet-882	25	40	4	4	NUM
admet-882	25	41	-	-	PUNCT
admet-882	25	42	n	n	PRON
admet-882	25	43	amine	amine	NOUN
admet-882	25	44	by	by	ADP
admet-882	25	45	cytidine	cytidine	NOUN
admet-882	25	46	deaminase	deaminase	PROPN
admet-882	25	47	(	(	PUNCT
admet-882	25	48	cda	cda	PROPN
admet-882	25	49	)	)	PUNCT
admet-882	25	50	,	,	PUNCT
admet-882	25	51	present	present	ADJ
admet-882	25	52	in	in	ADP
admet-882	25	53	high	high	ADJ
admet-882	25	54	levels	level	NOUN
admet-882	25	55	in	in	ADP
admet-882	25	56	both	both	DET
admet-882	25	57	human	human	ADJ
admet-882	25	58	plasma	plasma	NOUN
admet-882	25	59	and	and	CCONJ
admet-882	25	60	liver	liver	NOUN
admet-882	25	61	.	.	PUNCT
admet-882	26	1	as	as	SCONJ
admet-882	26	2	such	such	ADJ
admet-882	26	3	,	,	PUNCT
admet-882	26	4	much	much	ADV
admet-882	26	5	higher	high	ADJ
admet-882	26	6	doses	dose	NOUN
admet-882	26	7	are	be	AUX
admet-882	26	8	required	require	VERB
admet-882	26	9	to	to	PART
admet-882	26	10	reach	reach	VERB
admet-882	26	11	an	an	DET
admet-882	26	12	effective	effective	ADJ
admet-882	26	13	plasma	plasma	NOUN
admet-882	26	14	concentration	concentration	NOUN
admet-882	26	15	,	,	PUNCT
admet-882	26	16	increasing	increase	VERB
admet-882	26	17	toxicity	toxicity	NOUN
admet-882	26	18	and	and	CCONJ
admet-882	26	19	the	the	DET
admet-882	26	20	risk	risk	NOUN
admet-882	26	21	of	of	ADP
admet-882	26	22	adverse	adverse	ADJ
admet-882	26	23	side	side	NOUN
admet-882	26	24	effects	effect	NOUN
admet-882	26	25	.	.	PUNCT
admet-882	27	1	another	another	DET
admet-882	27	2	major	major	ADJ
admet-882	27	3	obstacle	obstacle	NOUN
admet-882	27	4	is	be	AUX
admet-882	27	5	the	the	DET
admet-882	27	6	drug	drug	NOUN
admet-882	27	7	resistance	resistance	NOUN
admet-882	27	8	related	relate	VERB
admet-882	27	9	to	to	PART
admet-882	27	10	nucleoside	nucleoside	VERB
admet-882	27	11	transporter	transporter	NOUN
admet-882	27	12	deficiency	deficiency	NOUN
admet-882	27	13	,	,	PUNCT
admet-882	27	14	which	which	PRON
admet-882	27	15	is	be	AUX
admet-882	27	16	developed	develop	VERB
admet-882	27	17	by	by	ADP
admet-882	27	18	some	some	DET
admet-882	27	19	tumor	tumor	NOUN
admet-882	27	20	cells	cell	NOUN
admet-882	27	21	after	after	ADP
admet-882	27	22	initial	initial	ADJ
admet-882	27	23	tumor	tumor	NOUN
admet-882	27	24	regression	regression	NOUN
admet-882	27	25	.	.	PUNCT
admet-882	28	1	as	as	ADP
admet-882	28	2	a	a	DET
admet-882	28	3	hydrophilic	hydrophilic	ADJ
admet-882	28	4	drug	drug	NOUN
admet-882	28	5	,	,	PUNCT
admet-882	28	6	gemcitabine	gemcitabine	NOUN
admet-882	28	7	cellular	cellular	ADJ
admet-882	28	8	uptake	uptake	NOUN
admet-882	28	9	is	be	AUX
admet-882	28	10	primarily	primarily	ADV
admet-882	28	11	facilitated	facilitate	VERB
admet-882	28	12	by	by	ADP
admet-882	28	13	the	the	DET
admet-882	28	14	human	human	ADJ
admet-882	28	15	equilibrative	equilibrative	ADJ
admet-882	28	16	nucleoside	nucleoside	NOUN
admet-882	28	17	transporter	transporter	NOUN
admet-882	28	18	1	1	NUM
admet-882	28	19	(	(	PUNCT
admet-882	28	20	hent1	hent1	NOUN
admet-882	28	21	)	)	PUNCT
admet-882	28	22	.	.	PUNCT
admet-882	29	1	thus	thus	ADV
admet-882	29	2	,	,	PUNCT
admet-882	29	3	the	the	DET
admet-882	29	4	expression	expression	NOUN
admet-882	29	5	of	of	ADP
admet-882	29	6	this	this	DET
admet-882	29	7	transporter	transporter	NOUN
admet-882	29	8	plays	play	VERB
admet-882	29	9	a	a	DET
admet-882	29	10	key	key	ADJ
admet-882	29	11	role	role	NOUN
admet-882	29	12	in	in	ADP
admet-882	29	13	gemcitabine	gemcitabine	NOUN
admet-882	29	14	intracellular	intracellular	ADJ
admet-882	29	15	uptake	uptake	ADJ
admet-882	29	16	[	[	X
admet-882	29	17	3	3	NUM
admet-882	29	18	]	]	PUNCT
admet-882	29	19	.	.	PUNCT
admet-882	30	1	there	there	PRON
admet-882	30	2	have	have	AUX
admet-882	30	3	been	be	AUX
admet-882	30	4	many	many	ADJ
admet-882	30	5	efforts	effort	NOUN
admet-882	30	6	to	to	PART
admet-882	30	7	improve	improve	VERB
admet-882	30	8	gemcitabine	gemcitabine	VERB
admet-882	30	9	clinical	clinical	ADJ
admet-882	30	10	efficacy	efficacy	NOUN
admet-882	30	11	and	and	CCONJ
admet-882	30	12	numerous	numerous	ADJ
admet-882	30	13	derivatives	derivative	NOUN
admet-882	30	14	and	and	CCONJ
admet-882	30	15	prodrugs	prodrug	NOUN
admet-882	30	16	have	have	AUX
admet-882	30	17	been	be	AUX
admet-882	30	18	designed	design	VERB
admet-882	30	19	to	to	PART
admet-882	30	20	alter	alter	VERB
admet-882	30	21	some	some	PRON
admet-882	30	22	of	of	ADP
admet-882	30	23	the	the	DET
admet-882	30	24	unfavorable	unfavorable	ADJ
admet-882	30	25	physicochemical	physicochemical	ADJ
admet-882	30	26	properties	property	NOUN
admet-882	30	27	of	of	ADP
admet-882	30	28	gemcitabine	gemcitabine	NOUN
admet-882	30	29	and	and	CCONJ
admet-882	30	30	ideally	ideally	ADV
admet-882	30	31	improve	improve	VERB
admet-882	30	32	its	its	PRON
admet-882	30	33	oral	oral	ADJ
admet-882	30	34	bioavailability	bioavailability	NOUN
admet-882	30	35	[	[	X
admet-882	30	36	4	4	NUM
admet-882	30	37	]	]	PUNCT
admet-882	30	38	.	.	PUNCT
admet-882	31	1	our	our	PRON
admet-882	31	2	research	research	NOUN
admet-882	31	3	group	group	NOUN
admet-882	31	4	has	have	AUX
admet-882	31	5	previously	previously	ADV
admet-882	31	6	developed	develop	VERB
admet-882	31	7	gemcitabine	gemcitabine	NOUN
admet-882	31	8	conjugates	conjugate	NOUN
admet-882	31	9	with	with	ADP
admet-882	31	10	cell	cell	NOUN
admet-882	31	11	-	-	PUNCT
admet-882	31	12	penetrating	penetrate	VERB
admet-882	31	13	peptides	peptide	NOUN
admet-882	31	14	(	(	PUNCT
admet-882	31	15	cpps	cpps	PROPN
admet-882	31	16	)	)	PUNCT
admet-882	31	17	to	to	PART
admet-882	31	18	facilitate	facilitate	VERB
admet-882	31	19	intracellular	intracellular	ADJ
admet-882	31	20	delivery	delivery	NOUN
admet-882	31	21	of	of	ADP
admet-882	31	22	this	this	DET
admet-882	31	23	drug	drug	NOUN
admet-882	32	1	[	[	X
admet-882	32	2	5	5	NUM
admet-882	32	3	-	-	SYM
admet-882	32	4	6	6	NUM
admet-882	32	5	]	]	PUNCT
admet-882	32	6	.	.	PUNCT
admet-882	33	1	in	in	ADP
admet-882	33	2	three	three	NUM
admet-882	33	3	of	of	ADP
admet-882	33	4	these	these	DET
admet-882	33	5	new	new	ADJ
admet-882	33	6	prodrugs	prodrug	NOUN
admet-882	33	7	,	,	PUNCT
admet-882	33	8	a	a	DET
admet-882	33	9	cell	cell	NOUN
admet-882	33	10	-	-	PUNCT
admet-882	33	11	penetrating	penetrate	VERB
admet-882	33	12	hexapeptide	hexapeptide	NOUN
admet-882	33	13	(	(	PUNCT
admet-882	33	14	cpp6	cpp6	PROPN
admet-882	33	15	)	)	PUNCT
admet-882	33	16	was	be	AUX
admet-882	33	17	covalently	covalently	ADV
admet-882	33	18	conjugated	conjugate	VERB
admet-882	33	19	to	to	ADP
admet-882	33	20	the	the	DET
admet-882	33	21	aniline	aniline	ADJ
admet-882	33	22	moiety	moiety	NOUN
admet-882	33	23	of	of	ADP
admet-882	33	24	gemcitabine	gemcitabine	NOUN
admet-882	33	25	through	through	ADP
admet-882	33	26	suitable	suitable	ADJ
admet-882	33	27	bio-/chemoreversible	bio-/chemoreversible	ADJ
admet-882	33	28	bonds	bond	NOUN
admet-882	33	29	.	.	PUNCT
admet-882	34	1	two	two	NUM
admet-882	34	2	cpp5	cpp5	NOUN
admet-882	34	3	(	(	PUNCT
admet-882	34	4	klpvm	klpvm	NOUN
admet-882	34	5	and	and	CCONJ
admet-882	34	6	vpmlk	vpmlk	NOUN
admet-882	34	7	)	)	PUNCT
admet-882	34	8	with	with	ADP
admet-882	34	9	reported	report	VERB
admet-882	34	10	high	high	ADJ
admet-882	34	11	percentage	percentage	NOUN
admet-882	34	12	of	of	ADP
admet-882	34	13	cell	cell	NOUN
admet-882	34	14	-	-	PUNCT
admet-882	34	15	penetration	penetration	NOUN
admet-882	34	16	were	be	AUX
admet-882	34	17	selected	select	VERB
admet-882	34	18	.	.	PUNCT
admet-882	35	1	one	one	NUM
admet-882	35	2	tryptophan	tryptophan	NOUN
admet-882	35	3	(	(	PUNCT
admet-882	35	4	trp	trp	NOUN
admet-882	35	5	)	)	PUNCT
admet-882	35	6	residue	residue	NOUN
admet-882	35	7	was	be	AUX
admet-882	35	8	added	add	VERB
admet-882	35	9	to	to	ADP
admet-882	35	10	the	the	DET
admet-882	35	11	terminal	terminal	NOUN
admet-882	35	12	of	of	ADP
admet-882	35	13	these	these	DET
admet-882	35	14	cpp5	cpp5	NOUN
admet-882	35	15	to	to	PART
admet-882	35	16	further	far	ADV
admet-882	35	17	improve	improve	VERB
admet-882	35	18	their	their	PRON
admet-882	35	19	capacity	capacity	NOUN
admet-882	35	20	of	of	ADP
admet-882	35	21	cell	cell	NOUN
admet-882	35	22	-	-	PUNCT
admet-882	35	23	penetration	penetration	NOUN
admet-882	35	24	,	,	PUNCT
admet-882	35	25	since	since	SCONJ
admet-882	35	26	trp	trp	PROPN
admet-882	35	27	has	have	VERB
admet-882	35	28	high	high	ADJ
admet-882	35	29	propensity	propensity	NOUN
admet-882	35	30	to	to	PART
admet-882	35	31	be	be	AUX
admet-882	35	32	inserted	insert	VERB
admet-882	35	33	into	into	ADP
admet-882	35	34	membranes	membrane	NOUN
admet-882	35	35	[	[	X
admet-882	35	36	7	7	NUM
admet-882	35	37	-	-	SYM
admet-882	35	38	8	8	NUM
admet-882	35	39	]	]	PUNCT
admet-882	35	40	,	,	PUNCT
admet-882	35	41	yielding	yield	VERB
admet-882	35	42	three	three	NUM
admet-882	35	43	novel	novel	ADJ
admet-882	35	44	hexapeptides	hexapeptide	NOUN
admet-882	35	45	:	:	PUNCT
admet-882	35	46	cpp6	cpp6	PROPN
admet-882	35	47	-	-	PUNCT
admet-882	35	48	1	1	NUM
admet-882	35	49	(	(	PUNCT
admet-882	35	50	wklpvm	wklpvm	NOUN
admet-882	35	51	)	)	PUNCT
admet-882	35	52	,	,	PUNCT
admet-882	35	53	cpp6	cpp6	NOUN
admet-882	35	54	-	-	PUNCT
admet-882	35	55	2	2	NUM
admet-882	35	56	(	(	PUNCT
admet-882	35	57	klpvmw	klpvmw	PROPN
admet-882	35	58	)	)	PUNCT
admet-882	35	59	,	,	PUNCT
admet-882	35	60	and	and	CCONJ
admet-882	35	61	cpp6	cpp6	PROPN
admet-882	35	62	-	-	PUNCT
admet-882	35	63	3	3	NUM
admet-882	35	64	(	(	PUNCT
admet-882	35	65	wvpmlk	wvpmlk	NOUN
admet-882	35	66	)	)	PUNCT
admet-882	35	67	.	.	PUNCT
admet-882	36	1	these	these	DET
admet-882	36	2	conjugates	conjugate	NOUN
admet-882	36	3	were	be	AUX
admet-882	36	4	designed	design	VERB
admet-882	36	5	to	to	PART
admet-882	36	6	facilitate	facilitate	VERB
admet-882	36	7	intracellular	intracellular	ADJ
admet-882	36	8	delivery	delivery	NOUN
admet-882	36	9	of	of	ADP
admet-882	36	10	this	this	DET
admet-882	36	11	drug	drug	NOUN
admet-882	36	12	and	and	CCONJ
admet-882	36	13	even	even	ADV
admet-882	36	14	overcome	overcome	VERB
admet-882	36	15	the	the	DET
admet-882	36	16	problem	problem	NOUN
admet-882	36	17	of	of	ADP
admet-882	36	18	transporter	transporter	NOUN
admet-882	36	19	deficiency	deficiency	NOUN
admet-882	36	20	related	relate	VERB
admet-882	36	21	drug	drug	NOUN
admet-882	36	22	resistance	resistance	NOUN
admet-882	36	23	,	,	PUNCT
admet-882	36	24	as	as	SCONJ
admet-882	36	25	cpps	cpp	NOUN
admet-882	36	26	are	be	AUX
admet-882	36	27	non	non	ADJ
admet-882	36	28	-	-	ADJ
admet-882	36	29	cytotoxic	cytotoxic	ADJ
admet-882	36	30	vectors	vector	NOUN
admet-882	36	31	and	and	CCONJ
admet-882	36	32	drug	drug	NOUN
admet-882	36	33	delivery	delivery	NOUN
admet-882	36	34	vehicles	vehicle	NOUN
admet-882	36	35	.	.	PUNCT
admet-882	37	1	additionally	additionally	ADV
admet-882	37	2	,	,	PUNCT
admet-882	37	3	gemcitabine	gemcitabine	NOUN
admet-882	37	4	is	be	AUX
admet-882	37	5	protected	protect	VERB
admet-882	37	6	from	from	ADP
admet-882	37	7	cda	cda	PROPN
admet-882	37	8	enzymatic	enzymatic	ADJ
admet-882	37	9	deamination	deamination	NOUN
admet-882	37	10	since	since	SCONJ
admet-882	37	11	its	its	PRON
admet-882	37	12	4	4	NUM
admet-882	37	13	-	-	PUNCT
admet-882	37	14	n	n	PRON
admet-882	37	15	amine	amine	NOUN
admet-882	37	16	was	be	AUX
admet-882	37	17	modified	modify	VERB
admet-882	37	18	.	.	PUNCT
admet-882	38	1	the	the	DET
admet-882	38	2	bioactivity	bioactivity	NOUN
admet-882	38	3	of	of	ADP
admet-882	38	4	these	these	DET
admet-882	38	5	new	new	ADJ
admet-882	38	6	prodrugs	prodrug	NOUN
admet-882	38	7	was	be	AUX
admet-882	38	8	previously	previously	ADV
admet-882	38	9	evaluated	evaluate	VERB
admet-882	38	10	in	in	ADP
admet-882	38	11	different	different	ADJ
admet-882	38	12	cell	cell	NOUN
admet-882	38	13	lines	line	NOUN
admet-882	38	14	and	and	CCONJ
admet-882	38	15	showed	show	VERB
admet-882	38	16	promising	promising	ADJ
admet-882	38	17	results	result	NOUN
admet-882	38	18	[	[	X
admet-882	38	19	5	5	NUM
admet-882	38	20	]	]	PUNCT
admet-882	38	21	.	.	PUNCT
admet-882	39	1	in	in	ADP
admet-882	39	2	this	this	DET
admet-882	39	3	work	work	NOUN
admet-882	39	4	,	,	PUNCT
admet-882	39	5	we	we	PRON
admet-882	39	6	have	have	AUX
admet-882	39	7	evaluated	evaluate	VERB
admet-882	39	8	the	the	DET
admet-882	39	9	absorption	absorption	NOUN
admet-882	39	10	and	and	CCONJ
admet-882	39	11	permeability	permeability	NOUN
admet-882	39	12	of	of	ADP
admet-882	39	13	gemcitabine	gemcitabine	NOUN
admet-882	39	14	,	,	PUNCT
admet-882	39	15	three	three	NUM
admet-882	39	16	cpp6	cpp6	NOUN
admet-882	39	17	and	and	CCONJ
admet-882	39	18	the	the	DET
admet-882	39	19	respective	respective	ADJ
admet-882	39	20	gem	gem	NOUN
admet-882	39	21	-	-	PUNCT
admet-882	39	22	cpp6	cpp6	NOUN
admet-882	39	23	conjugates	conjugate	NOUN
admet-882	39	24	across	across	ADP
admet-882	39	25	caco-2	caco-2	NUM
admet-882	39	26	monolayers	monolayer	NOUN
admet-882	39	27	.	.	PUNCT
admet-882	40	1	the	the	DET
admet-882	40	2	single	single	ADJ
admet-882	40	3	layer	layer	NOUN
admet-882	40	4	of	of	ADP
admet-882	40	5	epithelial	epithelial	ADJ
admet-882	40	6	cells	cell	NOUN
admet-882	40	7	that	that	PRON
admet-882	40	8	covers	cover	VERB
admet-882	40	9	the	the	DET
admet-882	40	10	inner	inner	ADJ
admet-882	40	11	intestinal	intestinal	ADJ
admet-882	40	12	wall	wall	NOUN
admet-882	40	13	forms	form	VERB
admet-882	40	14	the	the	DET
admet-882	40	15	rate	rate	NOUN
admet-882	40	16	-	-	PUNCT
admet-882	40	17	limiting	limit	VERB
admet-882	40	18	barrier	barrier	NOUN
admet-882	40	19	to	to	ADP
admet-882	40	20	the	the	DET
admet-882	40	21	absorption	absorption	NOUN
admet-882	40	22	of	of	ADP
admet-882	40	23	dissolved	dissolve	VERB
admet-882	40	24	compounds	compound	NOUN
admet-882	40	25	administered	administer	VERB
admet-882	40	26	orally	orally	ADV
admet-882	40	27	.	.	PUNCT
admet-882	41	1	consequently	consequently	ADV
admet-882	41	2	,	,	PUNCT
admet-882	41	3	proper	proper	ADJ
admet-882	41	4	reconstitution	reconstitution	NOUN
admet-882	41	5	of	of	ADP
admet-882	41	6	a	a	DET
admet-882	41	7	human	human	ADJ
admet-882	41	8	differentiated	differentiated	ADJ
admet-882	41	9	epithelial	epithelial	ADJ
admet-882	41	10	cell	cell	NOUN
admet-882	41	11	monolayer	monolayer	NOUN
admet-882	41	12	in	in	ADP
admet-882	41	13	vitro	vitro	X
admet-882	41	14	can	can	AUX
admet-882	41	15	be	be	AUX
admet-882	41	16	used	use	VERB
admet-882	41	17	to	to	PART
admet-882	41	18	predict	predict	VERB
admet-882	41	19	the	the	DET
admet-882	41	20	absorption	absorption	NOUN
admet-882	41	21	and	and	CCONJ
admet-882	41	22	permeability	permeability	NOUN
admet-882	41	23	coefficients	coefficient	NOUN
admet-882	41	24	of	of	ADP
admet-882	41	25	orally	orally	ADV
admet-882	41	26	administered	administer	VERB
admet-882	41	27	drugs	drug	NOUN
admet-882	41	28	.	.	PUNCT
admet-882	42	1	the	the	DET
admet-882	42	2	human	human	ADJ
admet-882	42	3	colon	colon	NOUN
admet-882	42	4	carcinoma	carcinoma	NOUN
admet-882	42	5	cell	cell	NOUN
admet-882	42	6	line	line	NOUN
admet-882	42	7	caco-2	caco-2	NUM
admet-882	42	8	has	have	AUX
admet-882	42	9	been	be	AUX
admet-882	42	10	successfully	successfully	ADV
admet-882	42	11	used	use	VERB
admet-882	42	12	to	to	PART
admet-882	42	13	fulfill	fulfill	VERB
admet-882	42	14	this	this	DET
admet-882	42	15	purpose	purpose	NOUN
admet-882	42	16	and	and	CCONJ
admet-882	42	17	monolayers	monolayer	NOUN
admet-882	42	18	grown	grow	VERB
admet-882	42	19	on	on	ADP
admet-882	42	20	permeable	permeable	ADJ
admet-882	42	21	filters	filter	NOUN
admet-882	42	22	have	have	AUX
admet-882	42	23	become	become	VERB
admet-882	42	24	the	the	DET
admet-882	42	25	in	in	ADV
admet-882	42	26	vitro	vitro	X
admet-882	42	27	golden	golden	ADJ
admet-882	42	28	standard	standard	NOUN
admet-882	42	29	for	for	ADP
admet-882	42	30	these	these	DET
admet-882	42	31	predictions	prediction	NOUN
admet-882	43	1	[	[	X
admet-882	43	2	9	9	NUM
admet-882	43	3	]	]	PUNCT
admet-882	43	4	.	.	PUNCT
admet-882	44	1	this	this	DET
admet-882	44	2	method	method	NOUN
admet-882	44	3	is	be	AUX
admet-882	44	4	recognized	recognize	VERB
admet-882	44	5	by	by	ADP
admet-882	44	6	the	the	DET
admet-882	44	7	american	american	ADJ
admet-882	44	8	food	food	PROPN
admet-882	44	9	and	and	CCONJ
admet-882	44	10	drug	drug	PROPN
admet-882	44	11	administration	administration	PROPN
admet-882	44	12	(	(	PUNCT
admet-882	44	13	fda	fda	PROPN
admet-882	44	14	)	)	PUNCT
admet-882	45	1	[	[	X
admet-882	45	2	10	10	NUM
admet-882	45	3	]	]	PUNCT
admet-882	45	4	.	.	PUNCT
admet-882	46	1	experimental	experimental	ADJ
admet-882	46	2	cell	cell	NOUN
admet-882	46	3	culture	culture	NOUN
admet-882	46	4	human	human	ADJ
admet-882	46	5	colon	colon	NOUN
admet-882	46	6	adenocarcinoma	adenocarcinoma	NOUN
admet-882	46	7	cell	cell	NOUN
admet-882	46	8	line	line	NOUN
admet-882	46	9	caco-2	caco-2	NUM
admet-882	46	10	(	(	PUNCT
admet-882	46	11	passage	passage	NOUN
admet-882	46	12	25	25	NUM
admet-882	46	13	-	-	SYM
admet-882	46	14	47	47	NUM
admet-882	46	15	,	,	PUNCT
admet-882	46	16	kindly	kindly	ADV
admet-882	46	17	provided	provide	VERB
admet-882	46	18	by	by	ADP
admet-882	46	19	the	the	DET
admet-882	46	20	department	department	NOUN
admet-882	46	21	of	of	ADP
admet-882	46	22	biomedicine	biomedicine	NOUN
admet-882	46	23	of	of	ADP
admet-882	46	24	the	the	DET
admet-882	46	25	faculty	faculty	NOUN
admet-882	46	26	of	of	ADP
admet-882	46	27	medicine	medicine	NOUN
admet-882	46	28	of	of	ADP
admet-882	46	29	university	university	PROPN
admet-882	46	30	of	of	ADP
admet-882	46	31	porto	porto	PROPN
admet-882	46	32	,	,	PUNCT
admet-882	46	33	and	and	CCONJ
admet-882	46	34	previously	previously	ADV
admet-882	46	35	acquired	acquire	VERB
admet-882	46	36	via	via	ADP
admet-882	46	37	atcc	atcc	NOUN
admet-882	46	38	)	)	PUNCT
admet-882	46	39	was	be	AUX
admet-882	46	40	routinely	routinely	ADV
admet-882	46	41	maintained	maintain	VERB
admet-882	46	42	in	in	ADP
admet-882	46	43	dulbecco	dulbecco	NOUN
admet-882	46	44	’s	’s	PART
admet-882	46	45	modified	modified	PROPN
admet-882	46	46	eagle	eagle	PROPN
admet-882	46	47	’s	’s	PART
admet-882	46	48	medium	medium	ADJ
admet-882	46	49	(	(	PUNCT
admet-882	46	50	dmem	dmem	ADJ
admet-882	46	51	)	)	PUNCT
admet-882	46	52	supplemented	supplement	VERB
admet-882	46	53	with	with	ADP
admet-882	46	54	10	10	NUM
admet-882	46	55	%	%	NOUN
admet-882	46	56	fetal	fetal	ADJ
admet-882	46	57	bovine	bovine	NOUN
admet-882	46	58	serum	serum	NOUN
admet-882	46	59	(	(	PUNCT
admet-882	46	60	fbs	fbs	PROPN
admet-882	46	61	)	)	PUNCT
admet-882	46	62	,	,	PUNCT
admet-882	46	63	l	l	NOUN
admet-882	46	64	-	-	NOUN
admet-882	46	65	glutamine	glutamine	NOUN
admet-882	46	66	and	and	CCONJ
admet-882	46	67	antibiotics	antibiotic	NOUN
admet-882	46	68	penicillin	penicillin	NOUN
admet-882	46	69	and	and	CCONJ
admet-882	46	70	streptomycin	streptomycin	PROPN
admet-882	46	71	.	.	PUNCT
admet-882	47	1	cells	cell	NOUN
admet-882	47	2	were	be	AUX
admet-882	47	3	cultured	cultured	ADJ
admet-882	47	4	at	at	ADP
admet-882	47	5	37	37	NUM
admet-882	47	6	°	°	NOUN
admet-882	47	7	c	c	NOUN
admet-882	47	8	in	in	ADP
admet-882	47	9	a	a	DET
admet-882	47	10	5	5	NUM
admet-882	47	11	%	%	NOUN
admet-882	47	12	co2	co2	NOUN
admet-882	47	13	humidified	humidify	VERB
admet-882	47	14	atmosphere	atmosphere	NOUN
admet-882	47	15	.	.	PUNCT
admet-882	48	1	culturing	culture	VERB
admet-882	48	2	medium	medium	NOUN
admet-882	48	3	was	be	AUX
admet-882	48	4	replaced	replace	VERB
admet-882	48	5	every	every	DET
admet-882	48	6	2	2	NUM
admet-882	48	7	-	-	SYM
admet-882	48	8	3	3	NUM
admet-882	48	9	days	day	NOUN
admet-882	48	10	and	and	CCONJ
admet-882	48	11	cell	cell	NOUN
admet-882	48	12	subculture	subculture	NOUN
admet-882	48	13	was	be	AUX
admet-882	48	14	conducted	conduct	VERB
admet-882	48	15	once	once	ADV
admet-882	48	16	a	a	DET
admet-882	48	17	week	week	NOUN
admet-882	48	18	by	by	ADP
admet-882	48	19	trypsinization	trypsinization	NOUN
admet-882	48	20	(	(	PUNCT
admet-882	48	21	0.25	0.25	NUM
admet-882	48	22	%	%	NOUN
admet-882	48	23	trypsin	trypsin	NOUN
admet-882	48	24	-	-	PUNCT
admet-882	48	25	edta	edta	NOUN
admet-882	48	26	wt	wt	NOUN
admet-882	48	27	/	/	SYM
admet-882	48	28	vol	vol	NOUN
admet-882	48	29	,	,	PUNCT
admet-882	48	30	5	5	NUM
admet-882	48	31	 	 	SPACE
admet-882	48	32	min	min	NOUN
admet-882	48	33	,	,	PUNCT
admet-882	48	34	37	37	NUM
admet-882	48	35	 	 	SPACE
admet-882	48	36	°	°	NOUN
admet-882	48	37	c	c	NOUN
admet-882	48	38	)	)	PUNCT
admet-882	48	39	.	.	PUNCT
admet-882	49	1	admet	admet	PROPN
admet-882	49	2	&	&	CCONJ
admet-882	49	3	dmpk	dmpk	PROPN
admet-882	49	4	9(1	9(1	NUM
admet-882	49	5	)	)	PUNCT
admet-882	49	6	(	(	PUNCT
admet-882	49	7	2021	2021	NUM
admet-882	49	8	)	)	PUNCT
admet-882	49	9	41	41	NUM
admet-882	49	10	-	-	SYM
admet-882	49	11	48	48	NUM
admet-882	49	12	permeability	permeability	NOUN
admet-882	49	13	of	of	ADP
admet-882	49	14	gemcitabine	gemcitabine	NOUN
admet-882	49	15	-	-	PUNCT
admet-882	49	16	cpp6	cpp6	NOUN
admet-882	49	17	conjugates	conjugate	NOUN
admet-882	49	18	in	in	ADP
admet-882	49	19	caco-2	caco-2	NUM
admet-882	49	20	cells	cell	NOUN
admet-882	49	21	doi	doi	NOUN
admet-882	49	22	:	:	PUNCT
admet-882	49	23	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	NOUN
admet-882	49	24	43	43	NUM
admet-882	49	25	cytotoxicity	cytotoxicity	NOUN
admet-882	49	26	assay	assay	VERB
admet-882	49	27	the	the	DET
admet-882	49	28	cell	cell	NOUN
admet-882	49	29	growth	growth	NOUN
admet-882	49	30	inhibitory	inhibitory	ADJ
admet-882	49	31	activity	activity	NOUN
admet-882	49	32	of	of	ADP
admet-882	49	33	gemcitabine	gemcitabine	NOUN
admet-882	49	34	in	in	ADP
admet-882	49	35	caco-2	caco-2	NUM
admet-882	49	36	cells	cell	NOUN
admet-882	49	37	was	be	AUX
admet-882	49	38	assessed	assess	VERB
admet-882	49	39	with	with	ADP
admet-882	49	40	the	the	DET
admet-882	49	41	mtt	mtt	NOUN
admet-882	49	42	assay	assay	VERB
admet-882	49	43	.	.	PUNCT
admet-882	50	1	briefly	briefly	ADV
admet-882	50	2	,	,	PUNCT
admet-882	50	3	a	a	DET
admet-882	50	4	growth	growth	NOUN
admet-882	50	5	curve	curve	NOUN
admet-882	50	6	was	be	AUX
admet-882	50	7	traced	trace	VERB
admet-882	50	8	to	to	PART
admet-882	50	9	determine	determine	VERB
admet-882	50	10	the	the	DET
admet-882	50	11	best	good	ADJ
admet-882	50	12	cell	cell	NOUN
admet-882	50	13	density	density	NOUN
admet-882	50	14	for	for	ADP
admet-882	50	15	the	the	DET
admet-882	50	16	assay	assay	NOUN
admet-882	50	17	.	.	PUNCT
admet-882	51	1	cells	cell	NOUN
admet-882	51	2	were	be	AUX
admet-882	51	3	seeded	seed	VERB
admet-882	51	4	in	in	ADP
admet-882	51	5	96well	96well	NUM
admet-882	51	6	plates	plate	NOUN
admet-882	51	7	(	(	PUNCT
admet-882	51	8	growth	growth	NOUN
admet-882	51	9	surface	surface	VERB
admet-882	51	10	0.322	0.322	NUM
admet-882	51	11	cm2	cm2	NOUN
admet-882	51	12	,	,	PUNCT
admet-882	51	13	from	from	ADP
admet-882	51	14	tpp	tpp	PROPN
admet-882	51	15	®	®	PROPN
admet-882	51	16	,	,	PUNCT
admet-882	51	17	product	product	NOUN
admet-882	51	18	no	no	NOUN
admet-882	51	19	.	.	NOUN
admet-882	51	20	92696	92696	NUM
admet-882	51	21	)	)	PUNCT
admet-882	51	22	with	with	ADP
admet-882	51	23	an	an	DET
admet-882	51	24	initial	initial	ADJ
admet-882	51	25	cell	cell	NOUN
admet-882	51	26	density	density	NOUN
admet-882	51	27	of	of	ADP
admet-882	51	28	9.3	9.3	NUM
admet-882	51	29	x	x	SYM
admet-882	51	30	103	103	NUM
admet-882	51	31	cells	cell	NOUN
admet-882	51	32	/	/	SYM
admet-882	51	33	ml	ml	PROPN
admet-882	51	34	(	(	PUNCT
admet-882	51	35	200	200	NUM
admet-882	51	36	μl	μl	INTJ
admet-882	51	37	per	per	ADP
admet-882	51	38	well	well	ADV
admet-882	51	39	)	)	PUNCT
admet-882	51	40	.	.	PUNCT
admet-882	52	1	cells	cell	NOUN
admet-882	52	2	were	be	AUX
admet-882	52	3	allowed	allow	VERB
admet-882	52	4	to	to	PART
admet-882	52	5	attach	attach	VERB
admet-882	52	6	for	for	ADP
admet-882	52	7	24	24	NUM
admet-882	52	8	h	h	NOUN
admet-882	52	9	and	and	CCONJ
admet-882	52	10	were	be	AUX
admet-882	52	11	then	then	ADV
admet-882	52	12	either	either	CCONJ
admet-882	52	13	left	leave	VERB
admet-882	52	14	untreated	untreated	ADJ
admet-882	52	15	(	(	PUNCT
admet-882	52	16	culture	culture	NOUN
admet-882	52	17	medium	medium	NOUN
admet-882	52	18	was	be	AUX
admet-882	52	19	replaced	replace	VERB
admet-882	52	20	for	for	ADP
admet-882	52	21	fresh	fresh	ADJ
admet-882	52	22	medium	medium	NOUN
admet-882	52	23	)	)	PUNCT
admet-882	52	24	or	or	CCONJ
admet-882	52	25	treated	treat	VERB
admet-882	52	26	with	with	ADP
admet-882	52	27	gemcitabine	gemcitabine	NOUN
admet-882	52	28	(	(	PUNCT
admet-882	52	29	0.1	0.1	NUM
admet-882	52	30	,	,	PUNCT
admet-882	52	31	1	1	NUM
admet-882	52	32	,	,	PUNCT
admet-882	52	33	5	5	NUM
admet-882	52	34	,	,	PUNCT
admet-882	52	35	10	10	NUM
admet-882	52	36	,	,	PUNCT
admet-882	52	37	20	20	NUM
admet-882	52	38	,	,	PUNCT
admet-882	52	39	50	50	NUM
admet-882	52	40	,	,	PUNCT
admet-882	52	41	100	100	NUM
admet-882	52	42	,	,	PUNCT
admet-882	52	43	1000	1000	NUM
admet-882	52	44	,	,	PUNCT
admet-882	52	45	10000	10000	NUM
admet-882	52	46	and	and	CCONJ
admet-882	52	47	100000	100000	NUM
admet-882	52	48	µm	µm	NOUN
admet-882	52	49	)	)	PUNCT
admet-882	52	50	.	.	PUNCT
admet-882	53	1	following	follow	VERB
admet-882	53	2	72	72	NUM
admet-882	53	3	h	h	NOUN
admet-882	53	4	incubation	incubation	NOUN
admet-882	53	5	,	,	PUNCT
admet-882	53	6	cell	cell	NOUN
admet-882	53	7	medium	medium	NOUN
admet-882	53	8	was	be	AUX
admet-882	53	9	removed	remove	VERB
admet-882	53	10	and	and	CCONJ
admet-882	53	11	100	100	NUM
admet-882	53	12	μl	μl	ADP
admet-882	53	13	of	of	ADP
admet-882	53	14	mtt	mtt	X
admet-882	53	15	(	(	PUNCT
admet-882	53	16	3(4,5	3(4,5	PROPN
admet-882	53	17	-	-	PUNCT
admet-882	53	18	dimethylthiazol-2	dimethylthiazol-2	NUM
admet-882	53	19	-	-	PUNCT
admet-882	53	20	yl)-2,5	yl)-2,5	NOUN
admet-882	53	21	-	-	PUNCT
admet-882	53	22	diphenyltetrazolium	diphenyltetrazolium	NOUN
admet-882	53	23	bromide	bromide	NOUN
admet-882	53	24	)	)	PUNCT
admet-882	53	25	solution	solution	NOUN
admet-882	53	26	were	be	AUX
admet-882	53	27	added	add	VERB
admet-882	53	28	per	per	ADP
admet-882	53	29	well	well	ADV
admet-882	53	30	.	.	PUNCT
admet-882	54	1	cells	cell	NOUN
admet-882	54	2	were	be	AUX
admet-882	54	3	then	then	ADV
admet-882	54	4	incubated	incubate	VERB
admet-882	54	5	for	for	ADP
admet-882	54	6	another	another	DET
admet-882	54	7	4	4	NUM
admet-882	54	8	h	h	NOUN
admet-882	54	9	protected	protect	VERB
admet-882	54	10	from	from	ADP
admet-882	54	11	light	light	NOUN
admet-882	54	12	.	.	PUNCT
admet-882	55	1	finally	finally	ADV
admet-882	55	2	,	,	PUNCT
admet-882	55	3	mtt	mtt	NOUN
admet-882	55	4	solution	solution	NOUN
admet-882	55	5	was	be	AUX
admet-882	55	6	removed	remove	VERB
admet-882	55	7	,	,	PUNCT
admet-882	55	8	dmso	dmso	NOUN
admet-882	55	9	(	(	PUNCT
admet-882	55	10	100	100	NUM
admet-882	55	11	μl	μl	ADP
admet-882	55	12	per	per	ADP
admet-882	55	13	well	well	ADV
admet-882	55	14	)	)	PUNCT
admet-882	55	15	was	be	AUX
admet-882	55	16	added	add	VERB
admet-882	55	17	to	to	PART
admet-882	55	18	solubilize	solubilize	VERB
admet-882	55	19	the	the	DET
admet-882	55	20	formazan	formazan	ADJ
admet-882	55	21	crystals	crystal	NOUN
admet-882	55	22	formed	form	VERB
admet-882	55	23	by	by	ADP
admet-882	55	24	viable	viable	ADJ
admet-882	55	25	cells	cell	NOUN
admet-882	55	26	and	and	CCONJ
admet-882	55	27	absorbance	absorbance	NOUN
admet-882	55	28	was	be	AUX
admet-882	55	29	measured	measure	VERB
admet-882	55	30	at	at	ADP
admet-882	55	31	570	570	NUM
admet-882	55	32	nm	nm	NOUN
admet-882	55	33	in	in	ADP
admet-882	55	34	an	an	DET
admet-882	55	35	automated	automate	VERB
admet-882	55	36	microplate	microplate	NOUN
admet-882	55	37	reader	reader	NOUN
admet-882	55	38	(	(	PUNCT
admet-882	55	39	sinergy	sinergy	PROPN
admet-882	55	40	ht	ht	PROPN
admet-882	55	41	,	,	PUNCT
admet-882	55	42	biotek	biotek	PROPN
admet-882	55	43	instruments	instruments	PROPN
admet-882	55	44	inc	inc	PROPN
admet-882	55	45	,	,	PUNCT
admet-882	55	46	vermont	vermont	PROPN
admet-882	55	47	,	,	PUNCT
admet-882	55	48	usa	usa	PROPN
admet-882	55	49	)	)	PUNCT
admet-882	55	50	.	.	PUNCT
admet-882	56	1	all	all	DET
admet-882	56	2	conditions	condition	NOUN
admet-882	56	3	were	be	AUX
admet-882	56	4	performed	perform	VERB
admet-882	56	5	in	in	ADP
admet-882	56	6	triplicate	triplicate	NOUN
admet-882	56	7	.	.	PUNCT
admet-882	57	1	gemcitabine	gemcitabine	NOUN
admet-882	57	2	cytotoxicity	cytotoxicity	NOUN
admet-882	57	3	results	result	NOUN
admet-882	57	4	were	be	AUX
admet-882	57	5	compared	compare	VERB
admet-882	57	6	with	with	ADP
admet-882	57	7	the	the	DET
admet-882	57	8	untreated	untreated	ADJ
admet-882	57	9	control	control	NOUN
admet-882	57	10	(	(	PUNCT
admet-882	57	11	mean	mean	NOUN
admet-882	57	12	of	of	ADP
admet-882	57	13	values	value	NOUN
admet-882	57	14	was	be	AUX
admet-882	57	15	set	set	VERB
admet-882	57	16	to	to	ADP
admet-882	57	17	100	100	NUM
admet-882	57	18	%	%	NOUN
admet-882	57	19	)	)	PUNCT
admet-882	57	20	and	and	CCONJ
admet-882	57	21	expressed	express	VERB
admet-882	57	22	as	as	ADP
admet-882	57	23	mean	mean	PROPN
admet-882	57	24	±	±	NUM
admet-882	57	25	sem	sem	NOUN
admet-882	57	26	.	.	PUNCT
admet-882	58	1	the	the	DET
admet-882	58	2	statistical	statistical	ADJ
admet-882	58	3	significance	significance	NOUN
admet-882	58	4	between	between	ADP
admet-882	58	5	different	different	ADJ
admet-882	58	6	gemcitabine	gemcitabine	NOUN
admet-882	58	7	concentrations	concentration	NOUN
admet-882	58	8	was	be	AUX
admet-882	58	9	analyzed	analyze	VERB
admet-882	58	10	in	in	ADP
admet-882	58	11	graphpad	graphpad	NOUN
admet-882	58	12	prism	prism	NOUN
admet-882	58	13	7	7	NUM
admet-882	58	14	(	(	PUNCT
admet-882	58	15	san	san	PROPN
admet-882	58	16	diego	diego	PROPN
admet-882	58	17	,	,	PUNCT
admet-882	58	18	eua	eua	PROPN
admet-882	58	19	)	)	PUNCT
admet-882	58	20	using	use	VERB
admet-882	58	21	one	one	NUM
admet-882	58	22	-	-	PUNCT
admet-882	58	23	way	way	NOUN
admet-882	58	24	anova	anova	X
admet-882	58	25	(	(	PUNCT
admet-882	58	26	p<0.05	p<0.05	NOUN
admet-882	58	27	)	)	PUNCT
admet-882	58	28	.	.	PUNCT
admet-882	59	1	scheme	scheme	NOUN
admet-882	59	2	1	1	NUM
admet-882	59	3	.	.	PUNCT
admet-882	59	4	chemical	chemical	ADJ
admet-882	59	5	structure	structure	NOUN
admet-882	59	6	of	of	ADP
admet-882	59	7	gemcitabine	gemcitabine	NOUN
admet-882	59	8	(	(	PUNCT
admet-882	59	9	before	before	ADP
admet-882	59	10	and	and	CCONJ
admet-882	59	11	after	after	ADP
admet-882	59	12	modification	modification	NOUN
admet-882	59	13	and	and	CCONJ
admet-882	59	14	conjugation	conjugation	NOUN
admet-882	59	15	with	with	ADP
admet-882	59	16	cpp6	cpp6	PROPN
admet-882	59	17	)	)	PUNCT
admet-882	59	18	and	and	CCONJ
admet-882	59	19	of	of	ADP
admet-882	59	20	the	the	DET
admet-882	59	21	three	three	NUM
admet-882	59	22	cpp6	cpp6	NOUN
admet-882	59	23	studied	study	VERB
admet-882	59	24	,	,	PUNCT
admet-882	59	25	cpp6	cpp6	PROPN
admet-882	59	26	-	-	PUNCT
admet-882	59	27	1	1	NUM
admet-882	59	28	(	(	PUNCT
admet-882	59	29	wklpvm	wklpvm	NOUN
admet-882	59	30	)	)	PUNCT
admet-882	59	31	,	,	PUNCT
admet-882	59	32	cpp6	cpp6	NOUN
admet-882	59	33	-	-	PUNCT
admet-882	59	34	2	2	NUM
admet-882	59	35	(	(	PUNCT
admet-882	59	36	klpvmw	klpvmw	PROPN
admet-882	59	37	)	)	PUNCT
admet-882	59	38	and	and	CCONJ
admet-882	59	39	cpp6	cpp6	PROPN
admet-882	59	40	-	-	PUNCT
admet-882	59	41	3	3	NUM
admet-882	59	42	(	(	PUNCT
admet-882	59	43	wvpmlk	wvpmlk	NOUN
admet-882	59	44	)	)	PUNCT
admet-882	59	45	.	.	PUNCT
admet-882	60	1	preparation	preparation	NOUN
admet-882	60	2	of	of	ADP
admet-882	60	3	cpps	cpps	NOUN
admet-882	60	4	and	and	CCONJ
admet-882	60	5	gemcitabine	gemcitabine	NOUN
admet-882	60	6	-	-	PUNCT
admet-882	60	7	cpp6	cpp6	NOUN
admet-882	60	8	conjugates	conjugate	NOUN
admet-882	60	9	all	all	DET
admet-882	60	10	the	the	DET
admet-882	60	11	compounds	compound	NOUN
admet-882	60	12	evaluated	evaluate	VERB
admet-882	60	13	in	in	ADP
admet-882	60	14	this	this	DET
admet-882	60	15	work	work	NOUN
admet-882	60	16	(	(	PUNCT
admet-882	60	17	except	except	SCONJ
admet-882	60	18	for	for	ADP
admet-882	60	19	gemcitabine	gemcitabine	NOUN
admet-882	60	20	,	,	PUNCT
admet-882	60	21	that	that	PRON
admet-882	60	22	was	be	AUX
admet-882	60	23	purchase	purchase	NOUN
admet-882	60	24	from	from	ADP
admet-882	60	25	sigmaaldrich	sigmaaldrich	NOUN
admet-882	60	26	as	as	ADP
admet-882	60	27	gemcitabine	gemcitabine	NOUN
admet-882	60	28	hydrochloride	hydrochloride	NOUN
admet-882	60	29	,	,	PUNCT
admet-882	60	30	g6423	g6423	NOUN
admet-882	60	31	)	)	PUNCT
admet-882	60	32	had	have	AUX
admet-882	60	33	been	be	AUX
admet-882	60	34	previously	previously	ADV
admet-882	60	35	synthesized	synthesize	VERB
admet-882	60	36	by	by	ADP
admet-882	60	37	our	our	PRON
admet-882	60	38	research	research	NOUN
admet-882	60	39	group	group	NOUN
admet-882	60	40	[	[	X
admet-882	60	41	5	5	NUM
admet-882	60	42	]	]	PUNCT
admet-882	60	43	.	.	PUNCT
admet-882	61	1	briefly	briefly	NOUN
admet-882	61	2	,	,	PUNCT
admet-882	61	3	cpp6	cpp6	PROPN
admet-882	61	4	-	-	PUNCT
admet-882	61	5	1	1	NUM
admet-882	61	6	(	(	PUNCT
admet-882	61	7	wklpvm	wklpvm	NOUN
admet-882	61	8	)	)	PUNCT
admet-882	61	9	,	,	PUNCT
admet-882	61	10	cpp6	cpp6	NOUN
admet-882	61	11	-	-	PUNCT
admet-882	61	12	2	2	NUM
admet-882	61	13	(	(	PUNCT
admet-882	61	14	klpvmw	klpvmw	PROPN
admet-882	61	15	)	)	PUNCT
admet-882	61	16	and	and	CCONJ
admet-882	61	17	cpp6	cpp6	PROPN
admet-882	61	18	-	-	PUNCT
admet-882	61	19	3	3	NUM
admet-882	61	20	(	(	PUNCT
admet-882	61	21	wvptlk	wvptlk	PROPN
admet-882	61	22	)	)	PUNCT
admet-882	61	23	were	be	AUX
admet-882	61	24	manually	manually	ADV
admet-882	61	25	synthesized	synthesize	VERB
admet-882	61	26	using	use	VERB
admet-882	61	27	gemcitabine	gemcitabine	NOUN
admet-882	61	28	gemcitabine	gemcitabine	NOUN
admet-882	61	29	gemcitabine	gemcitabine	PROPN
admet-882	61	30	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	61	31	n.	n.	PROPN
admet-882	61	32	vale	vale	PROPN
admet-882	61	33	et	et	PROPN
admet-882	61	34	al	al	PROPN
admet-882	61	35	.	.	PROPN
admet-882	61	36	admet	admet	PROPN
admet-882	61	37	&	&	CCONJ
admet-882	61	38	dmpk	dmpk	PROPN
admet-882	61	39	9(1	9(1	NUM
admet-882	61	40	)	)	PUNCT
admet-882	61	41	(	(	PUNCT
admet-882	61	42	2021	2021	NUM
admet-882	61	43	)	)	PUNCT
admet-882	61	44	41	41	NUM
admet-882	61	45	-	-	SYM
admet-882	61	46	48	48	NUM
admet-882	61	47	44	44	NUM
admet-882	61	48	standard	standard	ADJ
admet-882	61	49	solid	solid	ADJ
admet-882	61	50	phase	phase	NOUN
admet-882	61	51	peptide	peptide	NOUN
admet-882	61	52	synthesis	synthesis	NOUN
admet-882	61	53	(	(	PUNCT
admet-882	61	54	spps	spp	NOUN
admet-882	61	55	)	)	PUNCT
admet-882	61	56	and	and	CCONJ
admet-882	61	57	fmoc	fmoc	NOUN
admet-882	61	58	chemistry	chemistry	NOUN
admet-882	61	59	.	.	PUNCT
admet-882	62	1	gemcitabine	gemcitabine	NOUN
admet-882	62	2	was	be	AUX
admet-882	62	3	modified	modify	VERB
admet-882	62	4	to	to	PART
admet-882	62	5	allow	allow	VERB
admet-882	62	6	conjugation	conjugation	NOUN
admet-882	62	7	with	with	ADP
admet-882	62	8	cpp6	cpp6	PROPN
admet-882	62	9	.	.	PUNCT
admet-882	63	1	first	first	ADV
admet-882	63	2	,	,	PUNCT
admet-882	63	3	the	the	DET
admet-882	63	4	two	two	NUM
admet-882	63	5	hydroxyl	hydroxyl	NOUN
admet-882	63	6	groups	group	NOUN
admet-882	63	7	of	of	ADP
admet-882	63	8	gemcitabine	gemcitabine	NOUN
admet-882	63	9	were	be	AUX
admet-882	63	10	selectively	selectively	ADV
admet-882	63	11	protected	protect	VERB
admet-882	63	12	with	with	ADP
admet-882	63	13	boc	boc	NOUN
admet-882	63	14	groups	group	NOUN
admet-882	63	15	;	;	PUNCT
admet-882	63	16	then	then	ADV
admet-882	63	17	,	,	PUNCT
admet-882	63	18	succinic	succinic	ADJ
admet-882	63	19	anhydride	anhydride	NOUN
admet-882	63	20	was	be	AUX
admet-882	63	21	linked	link	VERB
admet-882	63	22	to	to	ADP
admet-882	63	23	the	the	DET
admet-882	63	24	4	4	NUM
admet-882	63	25	-	-	PUNCT
admet-882	63	26	n	n	PRON
admet-882	63	27	amine	amine	ADJ
admet-882	63	28	and	and	CCONJ
admet-882	63	29	lastly	lastly	ADV
admet-882	63	30	a	a	DET
admet-882	63	31	cpp6	cpp6	NOUN
admet-882	63	32	was	be	AUX
admet-882	63	33	conjugated	conjugate	VERB
admet-882	63	34	to	to	ADP
admet-882	63	35	this	this	DET
admet-882	63	36	anticancer	anticancer	NOUN
admet-882	63	37	drug	drug	NOUN
admet-882	63	38	.	.	PUNCT
admet-882	64	1	some	some	DET
admet-882	64	2	properties	property	NOUN
admet-882	64	3	of	of	ADP
admet-882	64	4	these	these	DET
admet-882	64	5	new	new	ADJ
admet-882	64	6	conjugates	conjugate	NOUN
admet-882	64	7	are	be	AUX
admet-882	64	8	presented	present	VERB
admet-882	64	9	in	in	ADP
admet-882	64	10	table	table	NOUN
admet-882	64	11	1	1	NUM
admet-882	64	12	.	.	PUNCT
admet-882	65	1	permeability	permeability	NOUN
admet-882	65	2	assay	assay	VERB
admet-882	65	3	a	a	DET
admet-882	65	4	monolayer	monolayer	NOUN
admet-882	65	5	of	of	ADP
admet-882	65	6	caco-2	caco-2	NUM
admet-882	65	7	cells	cell	NOUN
admet-882	65	8	was	be	AUX
admet-882	65	9	established	establish	VERB
admet-882	65	10	in	in	ADP
admet-882	65	11	a	a	DET
admet-882	65	12	12	12	NUM
admet-882	65	13	-	-	PUNCT
admet-882	65	14	well	well	NOUN
admet-882	65	15	plate	plate	NOUN
admet-882	66	1	[	[	X
admet-882	66	2	11	11	NUM
admet-882	66	3	]	]	PUNCT
admet-882	66	4	.	.	PUNCT
admet-882	67	1	each	each	DET
admet-882	67	2	well	well	ADV
admet-882	67	3	contains	contain	VERB
admet-882	67	4	a	a	DET
admet-882	67	5	permeable	permeable	ADJ
admet-882	67	6	filter	filter	NOUN
admet-882	67	7	insert	insert	NOUN
admet-882	67	8	,	,	PUNCT
admet-882	67	9	a	a	DET
admet-882	67	10	transparent	transparent	ADJ
admet-882	67	11	collagen	collagen	NOUN
admet-882	67	12	treated	treat	VERB
admet-882	67	13	(	(	PUNCT
admet-882	67	14	equimolar	equimolar	NOUN
admet-882	67	15	mixture	mixture	NOUN
admet-882	67	16	of	of	ADP
admet-882	67	17	types	type	NOUN
admet-882	67	18	i	i	PRON
admet-882	67	19	and	and	CCONJ
admet-882	67	20	iii	iii	NUM
admet-882	67	21	collagen	collagen	NOUN
admet-882	67	22	)	)	PUNCT
admet-882	67	23	polytetrafluoroethylene	polytetrafluoroethylene	NOUN
admet-882	67	24	(	(	PUNCT
admet-882	67	25	ptfe	ptfe	NOUN
admet-882	67	26	)	)	PUNCT
admet-882	67	27	membrane	membrane	NOUN
admet-882	67	28	,	,	PUNCT
admet-882	67	29	with	with	ADP
admet-882	67	30	12	12	NUM
admet-882	67	31	mm	mm	NOUN
admet-882	67	32	diameter	diameter	NOUN
admet-882	67	33	and	and	CCONJ
admet-882	67	34	0.4	0.4	NUM
admet-882	67	35	µm	µm	ADP
admet-882	67	36	pore	pore	ADJ
admet-882	67	37	(	(	PUNCT
admet-882	67	38	corning	corning	PROPN
admet-882	67	39	inc	inc	PROPN
admet-882	67	40	,	,	PUNCT
admet-882	67	41	corning	corning	NOUN
admet-882	67	42	transwell	transwell	PROPN
admet-882	67	43	col	col	PROPN
admet-882	67	44	collagen	collagen	NOUN
admet-882	67	45	coated	coat	VERB
admet-882	67	46	membrane	membrane	NOUN
admet-882	67	47	inserts	insert	NOUN
admet-882	67	48	,	,	PUNCT
admet-882	67	49	ny	ny	PROPN
admet-882	67	50	,	,	PUNCT
admet-882	67	51	usa	usa	PROPN
admet-882	67	52	,	,	PUNCT
admet-882	67	53	cat	cat	NOUN
admet-882	67	54	.	.	PUNCT
admet-882	68	1	no	no	INTJ
admet-882	68	2	.	.	NOUN
admet-882	68	3	3493	3493	NUM
admet-882	68	4	)	)	PUNCT
admet-882	68	5	.	.	PUNCT
admet-882	69	1	firstly	firstly	ADV
admet-882	69	2	,	,	PUNCT
admet-882	69	3	filters	filter	NOUN
admet-882	69	4	were	be	AUX
admet-882	69	5	pre	pre	ADJ
admet-882	69	6	-	-	ADJ
admet-882	69	7	wet	wet	ADJ
admet-882	69	8	with	with	ADP
admet-882	69	9	0.1	0.1	NUM
admet-882	69	10	ml	ml	NOUN
admet-882	69	11	of	of	ADP
admet-882	69	12	culture	culture	NOUN
admet-882	69	13	medium	medium	NOUN
admet-882	69	14	for	for	ADP
admet-882	69	15	2	2	NUM
admet-882	69	16	minutes	minute	NOUN
admet-882	69	17	.	.	PUNCT
admet-882	70	1	cells	cell	NOUN
admet-882	70	2	were	be	AUX
admet-882	70	3	seeded	seed	VERB
admet-882	70	4	in	in	ADP
admet-882	70	5	the	the	DET
admet-882	70	6	apical	apical	ADJ
admet-882	70	7	side	side	NOUN
admet-882	70	8	(	(	PUNCT
admet-882	70	9	0.5	0.5	NUM
admet-882	70	10	ml	ml	NOUN
admet-882	70	11	of	of	ADP
admet-882	70	12	cells	cell	NOUN
admet-882	70	13	per	per	ADP
admet-882	70	14	well	well	ADV
admet-882	70	15	,	,	PUNCT
admet-882	70	16	cell	cell	NOUN
admet-882	70	17	density	density	NOUN
admet-882	70	18	of	of	ADP
admet-882	70	19	4.0	4.0	NUM
admet-882	70	20	x	x	SYM
admet-882	70	21	105	105	NUM
admet-882	70	22	cells	cell	NOUN
admet-882	70	23	/	/	SYM
admet-882	70	24	ml	ml	NOUN
admet-882	70	25	)	)	PUNCT
admet-882	70	26	.	.	PUNCT
admet-882	71	1	the	the	DET
admet-882	71	2	basolateral	basolateral	ADJ
admet-882	71	3	compartment	compartment	NOUN
admet-882	71	4	was	be	AUX
admet-882	71	5	filled	fill	VERB
admet-882	71	6	with	with	ADP
admet-882	71	7	1.5	1.5	NUM
admet-882	71	8	ml	ml	NOUN
admet-882	71	9	of	of	ADP
admet-882	71	10	culture	culture	NOUN
admet-882	71	11	medium	medium	NOUN
admet-882	71	12	and	and	CCONJ
admet-882	71	13	plates	plate	NOUN
admet-882	71	14	were	be	AUX
admet-882	71	15	incubated	incubate	VERB
admet-882	71	16	for	for	ADP
admet-882	71	17	6	6	NUM
admet-882	71	18	h	h	NOUN
admet-882	71	19	(	(	PUNCT
admet-882	71	20	5	5	NUM
admet-882	71	21	%	%	NOUN
admet-882	71	22	co2	co2	NOUN
admet-882	71	23	humidified	humidify	VERB
admet-882	71	24	atmosphere	atmosphere	NOUN
admet-882	71	25	at	at	ADP
admet-882	71	26	37	37	NUM
admet-882	71	27	°	°	NOUN
admet-882	71	28	c	c	NOUN
admet-882	71	29	)	)	PUNCT
admet-882	71	30	.	.	PUNCT
admet-882	72	1	then	then	ADV
admet-882	72	2	,	,	PUNCT
admet-882	72	3	to	to	PART
admet-882	72	4	remove	remove	VERB
admet-882	72	5	non	non	ADJ
admet-882	72	6	-	-	ADJ
admet-882	72	7	adherent	adherent	ADJ
admet-882	72	8	cells	cell	NOUN
admet-882	72	9	and	and	CCONJ
admet-882	72	10	reduce	reduce	VERB
admet-882	72	11	the	the	DET
admet-882	72	12	risk	risk	NOUN
admet-882	72	13	of	of	ADP
admet-882	72	14	multilayer	multilayer	ADJ
admet-882	72	15	formation	formation	NOUN
admet-882	72	16	,	,	PUNCT
admet-882	72	17	the	the	DET
admet-882	72	18	medium	medium	NOUN
admet-882	72	19	in	in	ADP
admet-882	72	20	the	the	DET
admet-882	72	21	apical	apical	ADJ
admet-882	72	22	side	side	NOUN
admet-882	72	23	was	be	AUX
admet-882	72	24	removed	remove	VERB
admet-882	72	25	and	and	CCONJ
admet-882	72	26	replaced	replace	VERB
admet-882	72	27	with	with	ADP
admet-882	72	28	fresh	fresh	ADJ
admet-882	72	29	medium	medium	NOUN
admet-882	72	30	.	.	PUNCT
admet-882	73	1	cells	cell	NOUN
admet-882	73	2	were	be	AUX
admet-882	73	3	maintained	maintain	VERB
admet-882	73	4	for	for	ADP
admet-882	73	5	29	29	NUM
admet-882	73	6	days	day	NOUN
admet-882	73	7	,	,	PUNCT
admet-882	73	8	replacing	replace	VERB
admet-882	73	9	the	the	DET
admet-882	73	10	culture	culture	NOUN
admet-882	73	11	medium	medium	NOUN
admet-882	73	12	from	from	ADP
admet-882	73	13	both	both	DET
admet-882	73	14	compartments	compartment	NOUN
admet-882	73	15	every	every	DET
admet-882	73	16	other	other	ADJ
admet-882	73	17	day	day	NOUN
admet-882	73	18	.	.	PUNCT
admet-882	74	1	transport	transport	NOUN
admet-882	74	2	across	across	ADP
admet-882	74	3	caco-2	caco-2	NUM
admet-882	74	4	monolayer	monolayer	NOUN
admet-882	74	5	assay	assay	VERB
admet-882	74	6	all	all	DET
admet-882	74	7	the	the	DET
admet-882	74	8	solutions	solution	NOUN
admet-882	74	9	used	use	VERB
admet-882	74	10	were	be	AUX
admet-882	74	11	pre	pre	VERB
admet-882	74	12	-	-	VERB
admet-882	74	13	warmed	warm	VERB
admet-882	74	14	to	to	ADP
admet-882	74	15	37	37	NUM
admet-882	74	16	°	°	NOUN
admet-882	74	17	c	c	NOUN
admet-882	74	18	.	.	PUNCT
admet-882	75	1	culture	culture	NOUN
admet-882	75	2	medium	medium	NOUN
admet-882	75	3	was	be	AUX
admet-882	75	4	replaced	replace	VERB
admet-882	75	5	with	with	ADP
admet-882	75	6	fresh	fresh	ADJ
admet-882	75	7	medium	medium	ADJ
admet-882	75	8	24	24	NUM
admet-882	75	9	h	h	NOUN
admet-882	75	10	prior	prior	ADV
admet-882	75	11	the	the	DET
admet-882	75	12	beginning	beginning	NOUN
admet-882	75	13	of	of	ADP
admet-882	75	14	the	the	DET
admet-882	75	15	experiment	experiment	NOUN
admet-882	75	16	.	.	PUNCT
admet-882	76	1	next	next	ADV
admet-882	76	2	,	,	PUNCT
admet-882	76	3	this	this	DET
admet-882	76	4	culture	culture	NOUN
admet-882	76	5	medium	medium	NOUN
admet-882	76	6	was	be	AUX
admet-882	76	7	removed	remove	VERB
admet-882	76	8	first	first	ADV
admet-882	76	9	from	from	ADP
admet-882	76	10	the	the	DET
admet-882	76	11	basolateral	basolateral	NOUN
admet-882	76	12	and	and	CCONJ
admet-882	76	13	then	then	ADV
admet-882	76	14	from	from	ADP
admet-882	76	15	the	the	DET
admet-882	76	16	apical	apical	ADJ
admet-882	76	17	compartment	compartment	NOUN
admet-882	76	18	.	.	PUNCT
admet-882	77	1	the	the	DET
admet-882	77	2	apical	apical	ADJ
admet-882	77	3	compartment	compartment	NOUN
admet-882	77	4	was	be	AUX
admet-882	77	5	carefully	carefully	ADV
admet-882	77	6	washed	wash	VERB
admet-882	77	7	and	and	CCONJ
admet-882	77	8	then	then	ADV
admet-882	77	9	filled	fill	VERB
admet-882	77	10	with	with	ADP
admet-882	77	11	0.5	0.5	NUM
admet-882	77	12	ml	ml	NOUN
admet-882	77	13	of	of	ADP
admet-882	77	14	hank	hank	PROPN
admet-882	77	15	’s	’s	PART
admet-882	77	16	balanced	balanced	ADJ
admet-882	77	17	salt	salt	NOUN
admet-882	77	18	solution	solution	NOUN
admet-882	77	19	(	(	PUNCT
admet-882	77	20	hbss	hbss	NOUN
admet-882	77	21	,	,	PUNCT
admet-882	77	22	ph	ph	NOUN
admet-882	77	23	7.4	7.4	NUM
admet-882	77	24	)	)	PUNCT
admet-882	77	25	and	and	CCONJ
admet-882	77	26	the	the	DET
admet-882	77	27	basolateral	basolateral	ADJ
admet-882	77	28	compartment	compartment	NOUN
admet-882	77	29	was	be	AUX
admet-882	77	30	also	also	ADV
admet-882	77	31	filled	fill	VERB
admet-882	77	32	with	with	ADP
admet-882	77	33	1.5	1.5	NUM
admet-882	77	34	ml	ml	NOUN
admet-882	77	35	of	of	ADP
admet-882	77	36	hbss	hbss	NOUN
admet-882	77	37	.	.	PUNCT
admet-882	78	1	the	the	DET
admet-882	78	2	plates	plate	NOUN
admet-882	78	3	were	be	AUX
admet-882	78	4	incubated	incubate	VERB
admet-882	78	5	for	for	ADP
admet-882	78	6	17	17	NUM
admet-882	78	7	min	min	NOUN
admet-882	78	8	at	at	ADP
admet-882	78	9	37	37	NUM
admet-882	78	10	°	°	NOUN
admet-882	78	11	c	c	NOUN
admet-882	78	12	under	under	ADP
admet-882	78	13	gentle	gentle	ADJ
admet-882	78	14	shaking	shake	VERB
admet-882	78	15	(	(	PUNCT
admet-882	78	16	190	190	NUM
admet-882	78	17	rpm	rpm	NOUN
admet-882	78	18	,	,	PUNCT
admet-882	78	19	gfl	gfl	PROPN
admet-882	78	20	®	®	NOUN
admet-882	78	21	orbital	orbital	ADJ
admet-882	78	22	shaker	shaker	NOUN
admet-882	78	23	3015	3015	NUM
admet-882	78	24	)	)	PUNCT
admet-882	78	25	.	.	PUNCT
admet-882	79	1	all	all	DET
admet-882	79	2	tested	test	VERB
admet-882	79	3	compounds	compound	NOUN
admet-882	79	4	were	be	AUX
admet-882	79	5	prepared	prepare	VERB
admet-882	79	6	in	in	ADP
admet-882	79	7	hbbs	hbbs	PROPN
admet-882	79	8	(	(	PUNCT
admet-882	79	9	60	60	NUM
admet-882	79	10	µm	µm	NOUN
admet-882	79	11	)	)	PUNCT
admet-882	79	12	and	and	CCONJ
admet-882	79	13	added	add	VERB
admet-882	79	14	to	to	ADP
admet-882	79	15	the	the	DET
admet-882	79	16	apical	apical	ADJ
admet-882	79	17	compartment	compartment	NOUN
admet-882	79	18	.	.	PUNCT
admet-882	80	1	throughout	throughout	ADP
admet-882	80	2	this	this	DET
admet-882	80	3	assay	assay	NOUN
admet-882	80	4	,	,	PUNCT
admet-882	80	5	the	the	DET
admet-882	80	6	final	final	ADJ
admet-882	80	7	volume	volume	NOUN
admet-882	80	8	was	be	AUX
admet-882	80	9	0.4	0.4	NUM
admet-882	80	10	ml	ml	NOUN
admet-882	80	11	in	in	ADP
admet-882	80	12	the	the	DET
admet-882	80	13	apical	apical	ADJ
admet-882	80	14	compartment	compartment	NOUN
admet-882	80	15	and	and	CCONJ
admet-882	80	16	1.2	1.2	NUM
admet-882	80	17	ml	ml	NOUN
admet-882	80	18	in	in	ADP
admet-882	80	19	the	the	DET
admet-882	80	20	basolateral	basolateral	ADJ
admet-882	80	21	chamber	chamber	NOUN
admet-882	80	22	.	.	PUNCT
admet-882	81	1	at	at	ADP
admet-882	81	2	t	t	PROPN
admet-882	81	3	=	=	SYM
admet-882	81	4	0	0	NUM
admet-882	81	5	min	min	PROPN
admet-882	81	6	,	,	PUNCT
admet-882	81	7	0.45	0.45	NUM
admet-882	81	8	ml	ml	NOUN
admet-882	81	9	of	of	ADP
admet-882	81	10	the	the	DET
admet-882	81	11	donor	donor	NOUN
admet-882	81	12	solution	solution	NOUN
admet-882	81	13	was	be	AUX
admet-882	81	14	added	add	VERB
admet-882	81	15	to	to	ADP
admet-882	81	16	the	the	DET
admet-882	81	17	apical	apical	ADJ
admet-882	81	18	compartment	compartment	NOUN
admet-882	81	19	and	and	CCONJ
admet-882	81	20	a	a	DET
admet-882	81	21	sample	sample	NOUN
admet-882	81	22	(	(	PUNCT
admet-882	81	23	0.05	0.05	NUM
admet-882	81	24	ml	ml	NOUN
admet-882	81	25	)	)	PUNCT
admet-882	81	26	was	be	AUX
admet-882	81	27	immediately	immediately	ADV
admet-882	81	28	taken	take	VERB
admet-882	81	29	.	.	PUNCT
admet-882	82	1	the	the	DET
admet-882	82	2	plate	plate	NOUN
admet-882	82	3	was	be	AUX
admet-882	82	4	incubated	incubate	VERB
admet-882	82	5	(	(	PUNCT
admet-882	82	6	lid	lid	NOUN
admet-882	82	7	-	-	PUNCT
admet-882	82	8	covered	cover	VERB
admet-882	82	9	)	)	PUNCT
admet-882	82	10	at	at	ADP
admet-882	82	11	37	37	NUM
admet-882	82	12	°	°	NOUN
admet-882	82	13	c	c	NOUN
admet-882	82	14	under	under	ADP
admet-882	82	15	gentle	gentle	ADJ
admet-882	82	16	shaking	shake	VERB
admet-882	82	17	(	(	PUNCT
admet-882	82	18	190	190	NUM
admet-882	82	19	rpm	rpm	NOUN
admet-882	82	20	)	)	PUNCT
admet-882	82	21	.	.	PUNCT
admet-882	83	1	every	every	DET
admet-882	83	2	30	30	NUM
admet-882	83	3	min	min	NOUN
admet-882	83	4	for	for	ADP
admet-882	83	5	the	the	DET
admet-882	83	6	next	next	ADJ
admet-882	83	7	2	2	NUM
admet-882	83	8	h	h	NOUN
admet-882	83	9	,	,	PUNCT
admet-882	83	10	a	a	DET
admet-882	83	11	sample	sample	NOUN
admet-882	83	12	of	of	ADP
admet-882	83	13	0.6	0.6	NUM
admet-882	83	14	ml	ml	NOUN
admet-882	83	15	was	be	AUX
admet-882	83	16	taken	take	VERB
admet-882	83	17	from	from	ADP
admet-882	83	18	the	the	DET
admet-882	83	19	basolateral	basolateral	ADJ
admet-882	83	20	compartment	compartment	NOUN
admet-882	83	21	and	and	CCONJ
admet-882	83	22	replaced	replace	VERB
admet-882	83	23	with	with	ADP
admet-882	83	24	the	the	DET
admet-882	83	25	same	same	ADJ
admet-882	83	26	volume	volume	NOUN
admet-882	83	27	of	of	ADP
admet-882	83	28	hbss	hbss	NOUN
admet-882	83	29	.	.	PUNCT
admet-882	84	1	after	after	ADP
admet-882	84	2	120	120	NUM
admet-882	84	3	min	min	NOUN
admet-882	84	4	,	,	PUNCT
admet-882	84	5	a	a	DET
admet-882	84	6	sample	sample	NOUN
admet-882	84	7	of	of	ADP
admet-882	84	8	0.05	0.05	NUM
admet-882	84	9	ml	ml	NOUN
admet-882	84	10	was	be	AUX
admet-882	84	11	taken	take	VERB
admet-882	84	12	from	from	ADP
admet-882	84	13	the	the	DET
admet-882	84	14	apical	apical	ADJ
admet-882	84	15	side	side	NOUN
admet-882	84	16	.	.	PUNCT
admet-882	85	1	hplc	hplc	NOUN
admet-882	85	2	quantification	quantification	NOUN
admet-882	85	3	the	the	DET
admet-882	85	4	concentrations	concentration	NOUN
admet-882	85	5	of	of	ADP
admet-882	85	6	the	the	DET
admet-882	85	7	evaluated	evaluate	VERB
admet-882	85	8	compound	compound	NOUN
admet-882	85	9	in	in	ADP
admet-882	85	10	the	the	DET
admet-882	85	11	basolateral	basolateral	ADJ
admet-882	85	12	and	and	CCONJ
admet-882	85	13	apical	apical	ADJ
admet-882	85	14	compartments	compartment	NOUN
admet-882	85	15	were	be	AUX
admet-882	85	16	determined	determine	VERB
admet-882	85	17	by	by	ADP
admet-882	85	18	high	high	ADJ
admet-882	85	19	-	-	PUNCT
admet-882	85	20	performance	performance	NOUN
admet-882	85	21	liquid	liquid	ADJ
admet-882	85	22	chromatography	chromatography	NOUN
admet-882	85	23	(	(	PUNCT
admet-882	85	24	hplc	hplc	PROPN
admet-882	85	25	)	)	PUNCT
admet-882	85	26	(	(	PUNCT
admet-882	85	27	vwr	vwr	PROPN
admet-882	85	28	international	international	PROPN
admet-882	85	29	lcc	lcc	PROPN
admet-882	85	30	,	,	PUNCT
admet-882	85	31	lachrom	lachrom	NOUN
admet-882	85	32	ultra	ultra	PROPN
admet-882	85	33	,	,	PUNCT
admet-882	85	34	pennsylvania	pennsylvania	PROPN
admet-882	85	35	,	,	PUNCT
admet-882	85	36	usa	usa	PROPN
admet-882	85	37	)	)	PUNCT
admet-882	85	38	.	.	PUNCT
admet-882	86	1	elution	elution	NOUN
admet-882	86	2	was	be	AUX
admet-882	86	3	performed	perform	VERB
admet-882	86	4	with	with	ADP
admet-882	86	5	a	a	DET
admet-882	86	6	variable	variable	ADJ
admet-882	86	7	gradient	gradient	NOUN
admet-882	86	8	of	of	ADP
admet-882	86	9	acetonitrile	acetonitrile	NOUN
admet-882	86	10	(	(	PUNCT
admet-882	86	11	acn	acn	PROPN
admet-882	86	12	)	)	PUNCT
admet-882	86	13	in	in	ADP
admet-882	86	14	water	water	NOUN
admet-882	86	15	containing	contain	VERB
admet-882	86	16	0.05	0.05	NUM
admet-882	86	17	%	%	NOUN
admet-882	86	18	trifluoroacetic	trifluoroacetic	ADJ
admet-882	86	19	acid	acid	NOUN
admet-882	86	20	(	(	PUNCT
admet-882	86	21	tfa	tfa	NOUN
admet-882	86	22	)	)	PUNCT
admet-882	86	23	,	,	PUNCT
admet-882	86	24	at	at	ADP
admet-882	86	25	a	a	DET
admet-882	86	26	0.7	0.7	NUM
admet-882	86	27	ml	ml	NOUN
admet-882	86	28	/	/	SYM
admet-882	86	29	min	min	NOUN
admet-882	86	30	flow	flow	NOUN
admet-882	86	31	and	and	CCONJ
admet-882	86	32	detection	detection	NOUN
admet-882	86	33	at	at	ADP
admet-882	86	34	variable	variable	ADJ
admet-882	86	35	wavelength	wavelength	NOUN
admet-882	86	36	(	(	PUNCT
admet-882	86	37	243	243	NUM
admet-882	86	38	nm	nm	NOUN
admet-882	86	39	for	for	ADP
admet-882	86	40	gemcitabine	gemcitabine	NOUN
admet-882	86	41	and	and	CCONJ
admet-882	86	42	220	220	NUM
admet-882	86	43	nm	nm	NOUN
admet-882	86	44	for	for	ADP
admet-882	86	45	peptides	peptide	NOUN
admet-882	86	46	and	and	CCONJ
admet-882	86	47	conjugates	conjugate	NOUN
admet-882	86	48	)	)	PUNCT
admet-882	86	49	.	.	PUNCT
admet-882	87	1	all	all	DET
admet-882	87	2	chemicals	chemical	NOUN
admet-882	87	3	were	be	AUX
admet-882	87	4	either	either	CCONJ
admet-882	87	5	analytical	analytical	ADJ
admet-882	87	6	or	or	CCONJ
admet-882	87	7	hplc	hplc	NOUN
admet-882	87	8	grade	grade	NOUN
admet-882	87	9	.	.	PUNCT
admet-882	88	1	results	result	NOUN
admet-882	88	2	and	and	CCONJ
admet-882	88	3	discussion	discussion	NOUN
admet-882	88	4	gemcitabine	gemcitabine	NOUN
admet-882	88	5	cytotoxicity	cytotoxicity	NOUN
admet-882	88	6	every	every	DET
admet-882	88	7	concentration	concentration	NOUN
admet-882	88	8	of	of	ADP
admet-882	88	9	gemcitabine	gemcitabine	NOUN
admet-882	88	10	tested	test	VERB
admet-882	88	11	caused	cause	VERB
admet-882	88	12	a	a	DET
admet-882	88	13	statistically	statistically	ADV
admet-882	88	14	significant	significant	ADJ
admet-882	88	15	inhibition	inhibition	NOUN
admet-882	88	16	of	of	ADP
admet-882	88	17	cell	cell	NOUN
admet-882	88	18	growth	growth	NOUN
admet-882	88	19	in	in	ADP
admet-882	88	20	caco-2	caco-2	NUM
admet-882	88	21	cells	cell	NOUN
admet-882	88	22	compared	compare	VERB
admet-882	88	23	to	to	ADP
admet-882	88	24	untreated	untreated	ADJ
admet-882	88	25	cells	cell	NOUN
admet-882	88	26	(	(	PUNCT
admet-882	88	27	figure	figure	NOUN
admet-882	88	28	1	1	NUM
admet-882	88	29	)	)	PUNCT
admet-882	88	30	.	.	PUNCT
admet-882	89	1	the	the	DET
admet-882	89	2	maximum	maximum	ADJ
admet-882	89	3	inhibition	inhibition	NOUN
admet-882	89	4	was	be	AUX
admet-882	89	5	observed	observe	VERB
admet-882	89	6	after	after	ADP
admet-882	89	7	treatment	treatment	NOUN
admet-882	89	8	with	with	ADP
admet-882	89	9	the	the	DET
admet-882	89	10	highest	high	ADJ
admet-882	89	11	concentration	concentration	NOUN
admet-882	89	12	of	of	ADP
admet-882	89	13	gemcitabine	gemcitabine	NOUN
admet-882	89	14	evaluated	evaluate	VERB
admet-882	89	15	(	(	PUNCT
admet-882	89	16	100000	100000	NUM
admet-882	89	17	µm	µm	NOUN
admet-882	89	18	)	)	PUNCT
admet-882	89	19	.	.	PUNCT
admet-882	90	1	the	the	DET
admet-882	90	2	ic50	ic50	PROPN
admet-882	90	3	was	be	AUX
admet-882	90	4	calculated	calculate	VERB
admet-882	90	5	as	as	ADP
admet-882	90	6	52.4	52.4	NUM
admet-882	90	7	µm	µm	NOUN
admet-882	90	8	.	.	PUNCT
admet-882	91	1	admet	admet	PROPN
admet-882	91	2	&	&	CCONJ
admet-882	91	3	dmpk	dmpk	PROPN
admet-882	91	4	9(1	9(1	NUM
admet-882	91	5	)	)	PUNCT
admet-882	91	6	(	(	PUNCT
admet-882	91	7	2021	2021	NUM
admet-882	91	8	)	)	PUNCT
admet-882	91	9	41	41	NUM
admet-882	91	10	-	-	SYM
admet-882	91	11	48	48	NUM
admet-882	91	12	permeability	permeability	NOUN
admet-882	91	13	of	of	ADP
admet-882	91	14	gemcitabine	gemcitabine	NOUN
admet-882	91	15	-	-	PUNCT
admet-882	91	16	cpp6	cpp6	NOUN
admet-882	91	17	conjugates	conjugate	NOUN
admet-882	91	18	in	in	ADP
admet-882	91	19	caco-2	caco-2	NUM
admet-882	91	20	cells	cell	NOUN
admet-882	91	21	doi	doi	NOUN
admet-882	91	22	:	:	PUNCT
admet-882	91	23	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	91	24	45	45	NUM
admet-882	91	25	figure	figure	NOUN
admet-882	91	26	1	1	NUM
admet-882	91	27	.	.	PUNCT
admet-882	91	28	concentration	concentration	NOUN
admet-882	91	29	-	-	PUNCT
admet-882	91	30	dependent	dependent	ADJ
admet-882	91	31	cytotoxicity	cytotoxicity	NOUN
admet-882	91	32	of	of	ADP
admet-882	91	33	gemcitabine	gemcitabine	NOUN
admet-882	91	34	in	in	ADP
admet-882	91	35	caco-2	caco-2	NUM
admet-882	91	36	cells	cell	NOUN
admet-882	91	37	(	(	PUNCT
admet-882	91	38	abs	ab	NOUN
admet-882	91	39	570	570	NUM
admet-882	91	40	nm	nm	NOUN
admet-882	91	41	)	)	PUNCT
admet-882	91	42	.	.	PUNCT
admet-882	92	1	results	result	NOUN
admet-882	92	2	are	be	AUX
admet-882	92	3	presented	present	VERB
admet-882	92	4	as	as	ADP
admet-882	92	5	(	(	PUNCT
admet-882	92	6	a	a	X
admet-882	92	7	)	)	PUNCT
admet-882	92	8	the	the	DET
admet-882	92	9	percentage	percentage	NOUN
admet-882	92	10	of	of	ADP
admet-882	92	11	inhibition	inhibition	NOUN
admet-882	92	12	compared	compare	VERB
admet-882	92	13	to	to	PART
admet-882	92	14	control	control	VERB
admet-882	92	15	untreated	untreated	ADJ
admet-882	92	16	cells	cell	NOUN
admet-882	92	17	and	and	CCONJ
admet-882	92	18	(	(	PUNCT
admet-882	92	19	b	b	NOUN
admet-882	92	20	)	)	PUNCT
admet-882	92	21	plotted	plot	VERB
admet-882	92	22	as	as	ADP
admet-882	92	23	the	the	DET
admet-882	92	24	log	log	NOUN
admet-882	92	25	[	[	X
admet-882	92	26	gemcitabine	gemcitabine	NOUN
admet-882	92	27	]	]	PUNCT
admet-882	92	28	against	against	ADP
admet-882	92	29	the	the	DET
admet-882	92	30	percentage	percentage	NOUN
admet-882	92	31	of	of	ADP
admet-882	92	32	control	control	NOUN
admet-882	92	33	untreated	untreated	ADJ
admet-882	92	34	cells	cell	NOUN
admet-882	92	35	.	.	PUNCT
admet-882	93	1	results	result	NOUN
admet-882	93	2	are	be	AUX
admet-882	93	3	expressed	express	VERB
admet-882	93	4	as	as	ADP
admet-882	93	5	mean	mean	PROPN
admet-882	93	6	±	±	NUM
admet-882	93	7	sem	sem	NOUN
admet-882	93	8	(	(	PUNCT
admet-882	93	9	n=3	n=3	NOUN
admet-882	93	10	;	;	PUNCT
admet-882	93	11	p<0.05	p<0.05	NOUN
admet-882	93	12	,	,	PUNCT
admet-882	93	13	one	one	NUM
admet-882	93	14	-	-	PUNCT
admet-882	93	15	way	way	NOUN
admet-882	93	16	anova	anova	PROPN
admet-882	93	17	)	)	PUNCT
admet-882	93	18	.	.	PUNCT
admet-882	94	1	caco-2	caco-2	NUM
admet-882	94	2	monolayer	monolayer	NOUN
admet-882	94	3	and	and	CCONJ
admet-882	94	4	permeability	permeability	NOUN
admet-882	94	5	of	of	ADP
admet-882	94	6	gemcitabine	gemcitabine	NOUN
admet-882	94	7	microscopic	microscopic	ADJ
admet-882	94	8	analysis	analysis	NOUN
admet-882	94	9	of	of	ADP
admet-882	94	10	the	the	DET
admet-882	94	11	filter	filter	NOUN
admet-882	94	12	revealed	reveal	VERB
admet-882	94	13	a	a	DET
admet-882	94	14	uniformly	uniformly	ADV
admet-882	94	15	formed	form	VERB
admet-882	94	16	monolayer	monolayer	NOUN
admet-882	94	17	,	,	PUNCT
admet-882	94	18	with	with	ADP
admet-882	94	19	no	no	DET
admet-882	94	20	detection	detection	NOUN
admet-882	94	21	of	of	ADP
admet-882	94	22	anomalies	anomaly	NOUN
admet-882	94	23	or	or	CCONJ
admet-882	94	24	areas	area	NOUN
admet-882	94	25	without	without	ADP
admet-882	94	26	cells	cell	NOUN
admet-882	94	27	.	.	PUNCT
admet-882	95	1	a	a	DET
admet-882	95	2	caco-2	caco-2	NUM
admet-882	95	3	monolayer	monolayer	NOUN
admet-882	95	4	was	be	AUX
admet-882	95	5	successfully	successfully	ADV
admet-882	95	6	established	establish	VERB
admet-882	95	7	and	and	CCONJ
admet-882	95	8	this	this	PRON
admet-882	95	9	is	be	AUX
admet-882	95	10	a	a	DET
admet-882	95	11	reliable	reliable	ADJ
admet-882	95	12	indicator	indicator	NOUN
admet-882	95	13	for	for	ADP
admet-882	95	14	proceeding	proceed	VERB
admet-882	95	15	with	with	ADP
admet-882	95	16	the	the	DET
admet-882	95	17	permeability	permeability	NOUN
admet-882	95	18	study	study	NOUN
admet-882	95	19	.	.	PUNCT
admet-882	96	1	after	after	ADP
admet-882	96	2	30	30	NUM
admet-882	96	3	minutes	minute	NOUN
admet-882	96	4	,	,	PUNCT
admet-882	96	5	just	just	ADV
admet-882	96	6	3	3	NUM
admet-882	96	7	%	%	NOUN
admet-882	96	8	of	of	ADP
admet-882	96	9	gemcitabine	gemcitabine	NOUN
admet-882	96	10	was	be	AUX
admet-882	96	11	found	find	VERB
admet-882	96	12	in	in	ADP
admet-882	96	13	the	the	DET
admet-882	96	14	basolateral	basolateral	ADJ
admet-882	96	15	side	side	NOUN
admet-882	96	16	.	.	PUNCT
admet-882	97	1	at	at	ADP
admet-882	97	2	the	the	DET
admet-882	97	3	90	90	NUM
admet-882	97	4	min	min	NOUN
admet-882	97	5	time	time	NOUN
admet-882	97	6	point	point	NOUN
admet-882	97	7	,	,	PUNCT
admet-882	97	8	a	a	DET
admet-882	97	9	plateau	plateau	NOUN
admet-882	97	10	was	be	AUX
admet-882	97	11	reached	reach	VERB
admet-882	97	12	and	and	CCONJ
admet-882	97	13	only	only	ADV
admet-882	97	14	an	an	DET
admet-882	97	15	additional	additional	ADJ
admet-882	97	16	1	1	NUM
admet-882	97	17	%	%	NOUN
admet-882	97	18	of	of	ADP
admet-882	97	19	the	the	DET
admet-882	97	20	drug	drug	NOUN
admet-882	97	21	crossed	cross	VERB
admet-882	97	22	the	the	DET
admet-882	97	23	membrane	membrane	NOUN
admet-882	97	24	until	until	ADP
admet-882	97	25	the	the	DET
admet-882	97	26	end	end	NOUN
admet-882	97	27	of	of	ADP
admet-882	97	28	assay	assay	NOUN
admet-882	97	29	(	(	PUNCT
admet-882	97	30	120	120	NUM
admet-882	97	31	min	min	NOUN
admet-882	97	32	)	)	PUNCT
admet-882	97	33	,	,	PUNCT
admet-882	97	34	with	with	ADP
admet-882	97	35	a	a	DET
admet-882	97	36	total	total	NOUN
admet-882	97	37	of	of	ADP
admet-882	97	38	18	18	NUM
admet-882	97	39	%	%	NOUN
admet-882	97	40	of	of	ADP
admet-882	97	41	the	the	DET
admet-882	97	42	amount	amount	NOUN
admet-882	97	43	of	of	ADP
admet-882	97	44	gemcitabine	gemcitabine	NOUN
admet-882	97	45	initially	initially	ADV
admet-882	97	46	applied	apply	VERB
admet-882	97	47	in	in	ADP
admet-882	97	48	the	the	DET
admet-882	97	49	apical	apical	ADJ
admet-882	97	50	side	side	NOUN
admet-882	97	51	having	having	AUX
admet-882	97	52	crossed	cross	VERB
admet-882	97	53	into	into	ADP
admet-882	97	54	the	the	DET
admet-882	97	55	basolateral	basolateral	ADJ
admet-882	97	56	compartment	compartment	NOUN
admet-882	97	57	.	.	PUNCT
admet-882	98	1	permeability	permeability	NOUN
admet-882	98	2	of	of	ADP
admet-882	98	3	cpp6	cpp6	PROPN
admet-882	98	4	comparable	comparable	ADJ
admet-882	98	5	amounts	amount	NOUN
admet-882	98	6	of	of	ADP
admet-882	98	7	the	the	DET
admet-882	98	8	3	3	NUM
admet-882	98	9	cpp6	cpp6	NOUN
admet-882	98	10	crossed	cross	VERB
admet-882	98	11	the	the	DET
admet-882	98	12	monolayer	monolayer	NOUN
admet-882	98	13	of	of	ADP
admet-882	98	14	caco-2	caco-2	NUM
admet-882	98	15	cells	cell	NOUN
admet-882	98	16	after	after	ADP
admet-882	98	17	120	120	NUM
admet-882	98	18	minutes	minute	NOUN
admet-882	98	19	.	.	PUNCT
admet-882	99	1	still	still	ADV
admet-882	99	2	,	,	PUNCT
admet-882	99	3	cpp62	cpp62	PROPN
admet-882	99	4	exhibited	exhibit	VERB
admet-882	99	5	the	the	DET
admet-882	99	6	highest	high	ADJ
admet-882	99	7	permeability	permeability	NOUN
admet-882	99	8	,	,	PUNCT
admet-882	99	9	with	with	ADP
admet-882	99	10	40	40	NUM
admet-882	99	11	%	%	NOUN
admet-882	99	12	being	be	AUX
admet-882	99	13	recovered	recover	VERB
admet-882	99	14	in	in	ADP
admet-882	99	15	the	the	DET
admet-882	99	16	basolateral	basolateral	ADJ
admet-882	99	17	chamber	chamber	NOUN
admet-882	99	18	,	,	PUNCT
admet-882	99	19	followed	follow	VERB
admet-882	99	20	by	by	ADP
admet-882	99	21	cpp6	cpp6	PROPN
admet-882	99	22	-	-	PUNCT
admet-882	99	23	3	3	NUM
admet-882	99	24	(	(	PUNCT
admet-882	99	25	37	37	NUM
admet-882	99	26	%	%	NOUN
admet-882	99	27	)	)	PUNCT
admet-882	99	28	and	and	CCONJ
admet-882	99	29	cpp6	cpp6	PROPN
admet-882	99	30	-	-	PUNCT
admet-882	99	31	1	1	NUM
admet-882	99	32	(	(	PUNCT
admet-882	99	33	33	33	NUM
admet-882	99	34	%	%	NOUN
admet-882	99	35	)	)	PUNCT
admet-882	99	36	.	.	PUNCT
admet-882	100	1	during	during	ADP
admet-882	100	2	the	the	DET
admet-882	100	3	first	first	ADJ
admet-882	100	4	30	30	NUM
admet-882	100	5	minutes	minute	NOUN
admet-882	100	6	,	,	PUNCT
admet-882	100	7	only	only	ADV
admet-882	100	8	4	4	NUM
admet-882	100	9	to	to	PART
admet-882	100	10	5	5	NUM
admet-882	100	11	%	%	NOUN
admet-882	100	12	of	of	ADP
admet-882	100	13	all	all	DET
admet-882	100	14	cpps	cpp	NOUN
admet-882	100	15	reached	reach	VERB
admet-882	100	16	the	the	DET
admet-882	100	17	basolateral	basolateral	ADJ
admet-882	100	18	side	side	NOUN
admet-882	100	19	;	;	PUNCT
admet-882	100	20	the	the	DET
admet-882	100	21	rate	rate	NOUN
admet-882	100	22	of	of	ADP
admet-882	100	23	permeation	permeation	NOUN
admet-882	100	24	was	be	AUX
admet-882	100	25	highest	high	ADJ
admet-882	100	26	between	between	ADP
admet-882	100	27	30	30	NUM
admet-882	100	28	and	and	CCONJ
admet-882	100	29	90	90	NUM
admet-882	100	30	minutes	minute	NOUN
admet-882	100	31	.	.	PUNCT
admet-882	101	1	cpp6	cpp6	PROPN
admet-882	101	2	-	-	PUNCT
admet-882	101	3	2	2	NUM
admet-882	101	4	and	and	CCONJ
admet-882	101	5	cpp6	cpp6	PROPN
admet-882	101	6	-	-	PUNCT
admet-882	101	7	3	3	NUM
admet-882	101	8	registered	register	VERB
admet-882	101	9	a	a	DET
admet-882	101	10	decrease	decrease	NOUN
admet-882	101	11	in	in	ADP
admet-882	101	12	this	this	DET
admet-882	101	13	rate	rate	NOUN
admet-882	101	14	for	for	ADP
admet-882	101	15	the	the	DET
admet-882	101	16	last	last	ADJ
admet-882	101	17	30	30	NUM
admet-882	101	18	minutes	minute	NOUN
admet-882	101	19	of	of	ADP
admet-882	101	20	this	this	DET
admet-882	101	21	assay	assay	NOUN
admet-882	101	22	.	.	PUNCT
admet-882	102	1	throughout	throughout	ADP
admet-882	102	2	the	the	DET
admet-882	102	3	experiment	experiment	NOUN
admet-882	102	4	,	,	PUNCT
admet-882	102	5	a	a	DET
admet-882	102	6	slower	slow	ADJ
admet-882	102	7	rate	rate	NOUN
admet-882	102	8	of	of	ADP
admet-882	102	9	permeation	permeation	NOUN
admet-882	102	10	was	be	AUX
admet-882	102	11	observed	observe	VERB
admet-882	102	12	for	for	ADP
admet-882	102	13	cpp6	cpp6	NOUN
admet-882	102	14	-	-	PUNCT
admet-882	102	15	1	1	NUM
admet-882	102	16	(	(	PUNCT
admet-882	102	17	figure	figure	NOUN
admet-882	102	18	2	2	NUM
admet-882	102	19	)	)	PUNCT
admet-882	102	20	.	.	PUNCT
admet-882	103	1	by	by	ADP
admet-882	103	2	the	the	DET
admet-882	103	3	end	end	NOUN
admet-882	103	4	of	of	ADP
admet-882	103	5	the	the	DET
admet-882	103	6	experiment	experiment	NOUN
admet-882	103	7	,	,	PUNCT
admet-882	103	8	the	the	DET
admet-882	103	9	sum	sum	NOUN
admet-882	103	10	of	of	ADP
admet-882	103	11	the	the	DET
admet-882	103	12	cpp	cpp	NOUN
admet-882	103	13	absorbed	absorb	VERB
admet-882	103	14	from	from	ADP
admet-882	103	15	the	the	DET
admet-882	103	16	apical	apical	ADJ
admet-882	103	17	side	side	NOUN
admet-882	103	18	and	and	CCONJ
admet-882	103	19	found	find	VERB
admet-882	103	20	in	in	ADP
admet-882	103	21	the	the	DET
admet-882	103	22	basolateral	basolateral	ADJ
admet-882	103	23	chamber	chamber	NOUN
admet-882	103	24	was	be	AUX
admet-882	103	25	84	84	NUM
admet-882	103	26	%	%	NOUN
admet-882	103	27	for	for	ADP
admet-882	103	28	cpp6	cpp6	NOUN
admet-882	103	29	-	-	PUNCT
admet-882	103	30	2	2	NUM
admet-882	103	31	,	,	PUNCT
admet-882	103	32	75	75	NUM
admet-882	103	33	%	%	NOUN
admet-882	103	34	for	for	ADP
admet-882	103	35	cpp6	cpp6	NOUN
admet-882	103	36	-	-	PUNCT
admet-882	103	37	3	3	NUM
admet-882	103	38	and	and	CCONJ
admet-882	103	39	50	50	NUM
admet-882	103	40	%	%	NOUN
admet-882	103	41	for	for	ADP
admet-882	103	42	cpp6	cpp6	NOUN
admet-882	103	43	-	-	PUNCT
admet-882	103	44	1	1	NUM
admet-882	103	45	.	.	PUNCT
admet-882	104	1	this	this	PRON
admet-882	104	2	indicates	indicate	VERB
admet-882	104	3	that	that	SCONJ
admet-882	104	4	some	some	DET
admet-882	104	5	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	104	6	n.	n.	PROPN
admet-882	104	7	vale	vale	PROPN
admet-882	104	8	et	et	PROPN
admet-882	104	9	al	al	PROPN
admet-882	104	10	.	.	PROPN
admet-882	104	11	admet	admet	PROPN
admet-882	104	12	&	&	CCONJ
admet-882	104	13	dmpk	dmpk	PROPN
admet-882	104	14	9(1	9(1	NUM
admet-882	104	15	)	)	PUNCT
admet-882	104	16	(	(	PUNCT
admet-882	104	17	2021	2021	NUM
admet-882	104	18	)	)	PUNCT
admet-882	104	19	41	41	NUM
admet-882	104	20	-	-	SYM
admet-882	104	21	48	48	NUM
admet-882	104	22	46	46	NUM
admet-882	104	23	peptide	peptide	NOUN
admet-882	104	24	is	be	AUX
admet-882	104	25	retained	retain	VERB
admet-882	104	26	inside	inside	ADP
admet-882	104	27	the	the	DET
admet-882	104	28	cells	cell	NOUN
admet-882	104	29	or	or	CCONJ
admet-882	104	30	was	be	AUX
admet-882	104	31	degraded	degrade	VERB
admet-882	104	32	.	.	PUNCT
admet-882	105	1	figure	figure	NOUN
admet-882	105	2	2	2	NUM
admet-882	105	3	.	.	PUNCT
admet-882	105	4	concentration	concentration	NOUN
admet-882	105	5	of	of	ADP
admet-882	105	6	cpp6	cpp6	NOUN
admet-882	105	7	in	in	ADP
admet-882	105	8	the	the	DET
admet-882	105	9	basolateral	basolateral	ADJ
admet-882	105	10	compartment	compartment	NOUN
admet-882	105	11	after	after	ADP
admet-882	105	12	incubation	incubation	NOUN
admet-882	105	13	with	with	ADP
admet-882	105	14	60	60	NUM
admet-882	105	15	µm	µm	NOUN
admet-882	105	16	in	in	ADP
admet-882	105	17	the	the	DET
admet-882	105	18	apical	apical	ADJ
admet-882	105	19	compartment	compartment	NOUN
admet-882	105	20	and	and	CCONJ
admet-882	105	21	fitted	fit	VERB
admet-882	105	22	curves	curve	NOUN
admet-882	105	23	.	.	PUNCT
admet-882	106	1	permeability	permeability	NOUN
admet-882	106	2	of	of	ADP
admet-882	106	3	gem	gem	NOUN
admet-882	106	4	-	-	PUNCT
admet-882	106	5	cpp6	cpp6	NOUN
admet-882	106	6	conjugates	conjugate	NOUN
admet-882	106	7	as	as	ADP
admet-882	106	8	for	for	ADP
admet-882	106	9	the	the	DET
admet-882	106	10	gem	gem	NOUN
admet-882	106	11	-	-	PUNCT
admet-882	106	12	cpp6	cpp6	NOUN
admet-882	106	13	conjugates	conjugate	NOUN
admet-882	106	14	,	,	PUNCT
admet-882	106	15	the	the	DET
admet-882	106	16	conjugate	conjugate	NOUN
admet-882	106	17	of	of	ADP
admet-882	106	18	gemcitabine	gemcitabine	NOUN
admet-882	106	19	with	with	ADP
admet-882	106	20	cpp6	cpp6	PROPN
admet-882	106	21	-	-	PUNCT
admet-882	106	22	2	2	NUM
admet-882	106	23	clearly	clearly	ADV
admet-882	106	24	stands	stand	VERB
admet-882	106	25	out	out	ADP
admet-882	106	26	as	as	ADP
admet-882	106	27	the	the	DET
admet-882	106	28	most	most	ADV
admet-882	106	29	permeable	permeable	ADJ
admet-882	106	30	across	across	ADP
admet-882	106	31	the	the	DET
admet-882	106	32	caco-2	caco-2	NUM
admet-882	106	33	cell	cell	NOUN
admet-882	106	34	monolayer	monolayer	NOUN
admet-882	106	35	.	.	PUNCT
admet-882	107	1	the	the	DET
admet-882	107	2	extent	extent	NOUN
admet-882	107	3	of	of	ADP
admet-882	107	4	permeation	permeation	NOUN
admet-882	107	5	of	of	ADP
admet-882	107	6	this	this	DET
admet-882	107	7	conjugate	conjugate	NOUN
admet-882	107	8	was	be	AUX
admet-882	107	9	about	about	ADV
admet-882	107	10	3fold	3fold	NUM
admet-882	107	11	the	the	DET
admet-882	107	12	observed	observed	ADJ
admet-882	107	13	for	for	ADP
admet-882	107	14	the	the	DET
admet-882	107	15	gem	gem	NOUN
admet-882	107	16	-	-	PUNCT
admet-882	107	17	cpp6	cpp6	NOUN
admet-882	107	18	-	-	PUNCT
admet-882	107	19	1	1	NUM
admet-882	107	20	and	and	CCONJ
admet-882	107	21	gem	gem	NOUN
admet-882	107	22	-	-	PUNCT
admet-882	107	23	cpp6	cpp6	NOUN
admet-882	107	24	-	-	PUNCT
admet-882	107	25	3	3	NUM
admet-882	107	26	conjugates	conjugate	NOUN
admet-882	107	27	.	.	PUNCT
admet-882	108	1	approximately	approximately	ADV
admet-882	108	2	31	31	NUM
admet-882	108	3	%	%	NOUN
admet-882	108	4	of	of	ADP
admet-882	108	5	the	the	DET
admet-882	108	6	gem	gem	NOUN
admet-882	108	7	-	-	PUNCT
admet-882	108	8	cpp62	cpp62	PROPN
admet-882	108	9	conjugate	conjugate	NOUN
admet-882	108	10	was	be	AUX
admet-882	108	11	found	find	VERB
admet-882	108	12	in	in	ADP
admet-882	108	13	the	the	DET
admet-882	108	14	basolateral	basolateral	ADJ
admet-882	108	15	chamber	chamber	NOUN
admet-882	108	16	,	,	PUNCT
admet-882	108	17	while	while	SCONJ
admet-882	108	18	only	only	ADV
admet-882	108	19	9	9	NUM
admet-882	108	20	%	%	NOUN
admet-882	108	21	of	of	ADP
admet-882	108	22	gem	gem	NOUN
admet-882	108	23	-	-	PUNCT
admet-882	108	24	cpp6	cpp6	NOUN
admet-882	108	25	-	-	PUNCT
admet-882	108	26	1	1	NUM
admet-882	108	27	and	and	CCONJ
admet-882	108	28	gem	gem	NOUN
admet-882	108	29	-	-	PUNCT
admet-882	108	30	cpp6	cpp6	NOUN
admet-882	108	31	-	-	PUNCT
admet-882	108	32	3	3	NUM
admet-882	108	33	conjugates	conjugate	NOUN
admet-882	108	34	were	be	AUX
admet-882	108	35	able	able	ADJ
admet-882	108	36	to	to	PART
admet-882	108	37	cross	cross	VERB
admet-882	108	38	the	the	DET
admet-882	108	39	monolayer	monolayer	NOUN
admet-882	108	40	of	of	ADP
admet-882	108	41	caco-2	caco-2	NUM
admet-882	108	42	cells	cell	NOUN
admet-882	108	43	and	and	CCONJ
admet-882	108	44	was	be	AUX
admet-882	108	45	quantified	quantify	VERB
admet-882	108	46	in	in	ADP
admet-882	108	47	this	this	DET
admet-882	108	48	compartment	compartment	NOUN
admet-882	108	49	(	(	PUNCT
admet-882	108	50	figure	figure	NOUN
admet-882	108	51	3	3	NUM
admet-882	108	52	)	)	PUNCT
admet-882	108	53	.	.	PUNCT
admet-882	109	1	the	the	DET
admet-882	109	2	higher	high	ADJ
admet-882	109	3	permeability	permeability	NOUN
admet-882	109	4	of	of	ADP
admet-882	109	5	the	the	DET
admet-882	109	6	gem	gem	NOUN
admet-882	109	7	-	-	PUNCT
admet-882	109	8	cpp6	cpp6	NOUN
admet-882	109	9	-	-	PUNCT
admet-882	109	10	2	2	NUM
admet-882	109	11	conjugate	conjugate	NOUN
admet-882	109	12	is	be	AUX
admet-882	109	13	in	in	ADP
admet-882	109	14	agreement	agreement	NOUN
admet-882	109	15	with	with	ADP
admet-882	109	16	the	the	DET
admet-882	109	17	previous	previous	ADJ
admet-882	109	18	evaluation	evaluation	NOUN
admet-882	109	19	of	of	ADP
admet-882	109	20	the	the	DET
admet-882	109	21	permeability	permeability	NOUN
admet-882	109	22	of	of	ADP
admet-882	109	23	the	the	DET
admet-882	109	24	isolated	isolated	ADJ
admet-882	109	25	cpp6	cpp6	NOUN
admet-882	109	26	,	,	PUNCT
admet-882	109	27	with	with	ADP
admet-882	109	28	cpp6	cpp6	PROPN
admet-882	109	29	-	-	PUNCT
admet-882	109	30	2	2	NUM
admet-882	109	31	being	be	AUX
admet-882	109	32	the	the	DET
admet-882	109	33	most	most	ADV
admet-882	109	34	permeable	permeable	ADJ
admet-882	109	35	peptide	peptide	NOUN
admet-882	109	36	.	.	PUNCT
admet-882	110	1	of	of	ADP
admet-882	110	2	the	the	DET
admet-882	110	3	three	three	NUM
admet-882	110	4	studied	studied	ADJ
admet-882	110	5	cpp6	cpp6	NOUN
admet-882	110	6	,	,	PUNCT
admet-882	110	7	cpp6	cpp6	PROPN
admet-882	110	8	-	-	PUNCT
admet-882	110	9	2	2	NUM
admet-882	110	10	is	be	AUX
admet-882	110	11	the	the	DET
admet-882	110	12	only	only	ADJ
admet-882	110	13	one	one	NUM
admet-882	110	14	that	that	PRON
admet-882	110	15	has	have	VERB
admet-882	110	16	a	a	DET
admet-882	110	17	trp	trp	PROPN
admet-882	110	18	residue	residue	NOUN
admet-882	110	19	in	in	ADP
admet-882	110	20	its	its	PRON
admet-882	110	21	c	c	NOUN
admet-882	110	22	-	-	PUNCT
admet-882	110	23	terminal	terminal	ADJ
admet-882	110	24	(	(	PUNCT
admet-882	110	25	cpp6	cpp6	PROPN
admet-882	110	26	-	-	PUNCT
admet-882	110	27	1	1	NUM
admet-882	110	28	and	and	CCONJ
admet-882	110	29	cpp6	cpp6	PROPN
admet-882	110	30	-	-	PUNCT
admet-882	110	31	3	3	NUM
admet-882	110	32	have	have	VERB
admet-882	110	33	a	a	DET
admet-882	110	34	trp	trp	PROPN
admet-882	110	35	residue	residue	NOUN
admet-882	110	36	in	in	ADP
admet-882	110	37	the	the	DET
admet-882	110	38	n	n	CCONJ
admet-882	110	39	-	-	PUNCT
admet-882	110	40	terminal	terminal	ADJ
admet-882	110	41	position	position	NOUN
admet-882	110	42	)	)	PUNCT
admet-882	110	43	.	.	PUNCT
admet-882	111	1	additionally	additionally	ADV
admet-882	111	2	,	,	PUNCT
admet-882	111	3	the	the	DET
admet-882	111	4	only	only	ADJ
admet-882	111	5	difference	difference	NOUN
admet-882	111	6	between	between	ADP
admet-882	111	7	cpp6	cpp6	PROPN
admet-882	111	8	-	-	PUNCT
admet-882	111	9	1	1	NUM
admet-882	111	10	and	and	CCONJ
admet-882	111	11	cpp6	cpp6	PROPN
admet-882	111	12	-	-	PUNCT
admet-882	111	13	2	2	NUM
admet-882	111	14	is	be	AUX
admet-882	111	15	the	the	DET
admet-882	111	16	position	position	NOUN
admet-882	111	17	of	of	ADP
admet-882	111	18	this	this	DET
admet-882	111	19	amino	amino	NOUN
admet-882	111	20	acid	acid	NOUN
admet-882	111	21	residue	residue	NOUN
admet-882	111	22	(	(	PUNCT
admet-882	111	23	n	n	CCONJ
admet-882	111	24	-	-	PUNCT
admet-882	111	25	terminal	terminal	ADJ
admet-882	111	26	versus	versus	ADP
admet-882	111	27	c	c	NOUN
admet-882	111	28	-	-	PUNCT
admet-882	111	29	terminal	terminal	NOUN
admet-882	111	30	)	)	PUNCT
admet-882	111	31	.	.	PUNCT
admet-882	112	1	tryptophan	tryptophan	NOUN
admet-882	112	2	can	can	AUX
admet-882	112	3	be	be	AUX
admet-882	112	4	considered	consider	VERB
admet-882	112	5	hydrophobic	hydrophobic	ADJ
admet-882	112	6	due	due	ADP
admet-882	112	7	to	to	ADP
admet-882	112	8	its	its	PRON
admet-882	112	9	uncharged	uncharged	ADJ
admet-882	112	10	side	side	NOUN
admet-882	112	11	chain	chain	NOUN
admet-882	112	12	.	.	PUNCT
admet-882	113	1	given	give	VERB
admet-882	113	2	its	its	PRON
admet-882	113	3	aromatic	aromatic	ADJ
admet-882	113	4	character	character	NOUN
admet-882	113	5	,	,	PUNCT
admet-882	113	6	it	it	PRON
admet-882	113	7	can	can	AUX
admet-882	113	8	form	form	VERB
admet-882	113	9	hydrogen	hydrogen	NOUN
admet-882	113	10	bonds	bond	NOUN
admet-882	113	11	and	and	CCONJ
admet-882	113	12	strongly	strongly	ADV
admet-882	113	13	interact	interact	VERB
admet-882	113	14	with	with	ADP
admet-882	113	15	cellular	cellular	ADJ
admet-882	113	16	membranes	membrane	NOUN
admet-882	113	17	,	,	PUNCT
admet-882	113	18	disrupting	disrupt	VERB
admet-882	113	19	the	the	DET
admet-882	113	20	stability	stability	NOUN
admet-882	113	21	of	of	ADP
admet-882	113	22	the	the	DET
admet-882	113	23	membrane	membrane	NOUN
admet-882	113	24	lipidic	lipidic	ADJ
admet-882	113	25	chains	chain	NOUN
admet-882	113	26	.	.	PUNCT
admet-882	114	1	these	these	DET
admet-882	114	2	properties	property	NOUN
admet-882	114	3	grant	grant	VERB
admet-882	114	4	this	this	DET
admet-882	114	5	amino	amino	NOUN
admet-882	114	6	acid	acid	NOUN
admet-882	114	7	residue	residue	NOUN
admet-882	114	8	a	a	DET
admet-882	114	9	great	great	ADJ
admet-882	114	10	tendency	tendency	NOUN
admet-882	114	11	to	to	PART
admet-882	114	12	insert	insert	VERB
admet-882	114	13	into	into	ADP
admet-882	114	14	membranes	membrane	NOUN
admet-882	114	15	[	[	X
admet-882	114	16	12	12	NUM
admet-882	114	17	-	-	SYM
admet-882	114	18	15	15	NUM
admet-882	114	19	]	]	PUNCT
admet-882	114	20	.	.	PUNCT
admet-882	115	1	it	it	PRON
admet-882	115	2	has	have	AUX
admet-882	115	3	been	be	AUX
admet-882	115	4	shown	show	VERB
admet-882	115	5	that	that	SCONJ
admet-882	115	6	the	the	DET
admet-882	115	7	replacement	replacement	NOUN
admet-882	115	8	of	of	ADP
admet-882	115	9	the	the	DET
admet-882	115	10	2	2	NUM
admet-882	115	11	trp	trp	PROPN
admet-882	115	12	residues	residue	NOUN
admet-882	115	13	of	of	ADP
admet-882	115	14	the	the	DET
admet-882	115	15	known	know	VERB
admet-882	115	16	cpp	cpp	NOUN
admet-882	115	17	penetratin	penetratin	NOUN
admet-882	115	18	for	for	ADP
admet-882	115	19	phenylalanine	phenylalanine	NOUN
admet-882	115	20	residues	residue	NOUN
admet-882	115	21	completely	completely	ADV
admet-882	115	22	eliminates	eliminate	VERB
admet-882	115	23	the	the	DET
admet-882	115	24	penetration	penetration	NOUN
admet-882	115	25	ability	ability	NOUN
admet-882	115	26	of	of	ADP
admet-882	115	27	this	this	DET
admet-882	115	28	peptide	peptide	NOUN
admet-882	116	1	[	[	X
admet-882	116	2	16	16	NUM
admet-882	116	3	]	]	PUNCT
admet-882	116	4	.	.	PUNCT
admet-882	117	1	furthermore	furthermore	ADV
admet-882	117	2	,	,	PUNCT
admet-882	117	3	rydberg	rydberg	PROPN
admet-882	117	4	et	et	PROPN
admet-882	117	5	al	al	PROPN
admet-882	117	6	.	.	PROPN
admet-882	117	7	have	have	AUX
admet-882	117	8	reported	report	VERB
admet-882	117	9	that	that	SCONJ
admet-882	117	10	the	the	DET
admet-882	117	11	number	number	NOUN
admet-882	117	12	of	of	ADP
admet-882	117	13	trp	trp	PROPN
admet-882	117	14	residues	residue	NOUN
admet-882	117	15	in	in	ADP
admet-882	117	16	a	a	DET
admet-882	117	17	cpp	cpp	NOUN
admet-882	117	18	is	be	AUX
admet-882	117	19	relevant	relevant	ADJ
admet-882	117	20	,	,	PUNCT
admet-882	117	21	with	with	ADP
admet-882	117	22	a	a	DET
admet-882	117	23	higher	high	ADJ
admet-882	117	24	number	number	NOUN
admet-882	117	25	of	of	ADP
admet-882	117	26	trp	trp	PROPN
admet-882	117	27	residues	residue	NOUN
admet-882	117	28	in	in	ADP
admet-882	117	29	a	a	DET
admet-882	117	30	cpp	cpp	NOUN
admet-882	117	31	corresponding	corresponding	NOUN
admet-882	117	32	to	to	ADP
admet-882	117	33	greater	great	ADJ
admet-882	117	34	penetration	penetration	NOUN
admet-882	117	35	ability	ability	NOUN
admet-882	117	36	[	[	X
admet-882	117	37	12	12	NUM
admet-882	117	38	]	]	PUNCT
admet-882	117	39	.	.	PUNCT
admet-882	118	1	these	these	DET
admet-882	118	2	authors	author	NOUN
admet-882	118	3	have	have	AUX
admet-882	118	4	also	also	ADV
admet-882	118	5	demonstrated	demonstrate	VERB
admet-882	118	6	that	that	SCONJ
admet-882	118	7	the	the	DET
admet-882	118	8	position	position	NOUN
admet-882	118	9	of	of	ADP
admet-882	118	10	this	this	DET
admet-882	118	11	residue	residue	NOUN
admet-882	118	12	is	be	AUX
admet-882	118	13	another	another	DET
admet-882	118	14	factor	factor	NOUN
admet-882	118	15	influencing	influence	VERB
admet-882	118	16	permeability	permeability	NOUN
admet-882	118	17	;	;	PUNCT
admet-882	118	18	in	in	ADP
admet-882	118	19	this	this	DET
admet-882	118	20	case	case	NOUN
admet-882	118	21	,	,	PUNCT
admet-882	118	22	cpps	cpps	NOUN
admet-882	118	23	with	with	ADP
admet-882	118	24	trp	trp	PROPN
admet-882	118	25	residues	residue	NOUN
admet-882	118	26	in	in	ADP
admet-882	118	27	the	the	DET
admet-882	118	28	n	n	CCONJ
admet-882	118	29	-	-	PUNCT
admet-882	118	30	terminal	terminal	ADJ
admet-882	118	31	position	position	NOUN
admet-882	118	32	were	be	AUX
admet-882	118	33	less	less	ADV
admet-882	118	34	absorbed	absorb	VERB
admet-882	118	35	.	.	PUNCT
admet-882	119	1	some	some	DET
admet-882	119	2	properties	property	NOUN
admet-882	119	3	of	of	ADP
admet-882	119	4	these	these	DET
admet-882	119	5	new	new	ADJ
admet-882	119	6	gem	gem	NOUN
admet-882	119	7	-	-	PUNCT
admet-882	119	8	cpp6	cpp6	NOUN
admet-882	119	9	conjugates	conjugate	NOUN
admet-882	119	10	were	be	AUX
admet-882	119	11	predicted	predict	VERB
admet-882	119	12	using	use	VERB
admet-882	119	13	in	in	ADP
admet-882	119	14	silico	silico	NOUN
admet-882	119	15	tools	tool	NOUN
admet-882	119	16	and	and	CCONJ
admet-882	119	17	are	be	AUX
admet-882	119	18	presented	present	VERB
admet-882	119	19	in	in	ADP
admet-882	119	20	table	table	NOUN
admet-882	119	21	1	1	NUM
admet-882	119	22	.	.	PUNCT
admet-882	119	23	gem	gem	NOUN
admet-882	119	24	-	-	PUNCT
admet-882	119	25	cpp6	cpp6	PROPN
admet-882	119	26	-	-	PUNCT
admet-882	119	27	2	2	NUM
admet-882	119	28	has	have	VERB
admet-882	119	29	the	the	DET
admet-882	119	30	highest	high	ADJ
admet-882	119	31	calculated	calculate	VERB
admet-882	119	32	papp	papp	NOUN
admet-882	119	33	and	and	CCONJ
admet-882	119	34	is	be	AUX
admet-882	119	35	also	also	ADV
admet-882	119	36	predicted	predict	VERB
admet-882	119	37	as	as	ADP
admet-882	119	38	the	the	DET
admet-882	119	39	most	most	ADV
admet-882	119	40	permeable	permeable	ADJ
admet-882	119	41	conjugate	conjugate	NOUN
admet-882	119	42	by	by	ADP
admet-882	119	43	gastroplus	gastroplus	ADJ
admet-882	119	44	™	™	PROPN
admet-882	119	45	,	,	PUNCT
admet-882	119	46	a	a	DET
admet-882	119	47	mechanistically	mechanistically	ADV
admet-882	119	48	based	base	VERB
admet-882	119	49	pharmacokinetics	pharmacokinetic	NOUN
admet-882	119	50	and	and	CCONJ
admet-882	119	51	pharmacodynamics	pharmacodynamic	NOUN
admet-882	119	52	simulation	simulation	NOUN
admet-882	119	53	software	software	PROPN
admet-882	119	54	.	.	PUNCT
admet-882	120	1	admet	admet	PROPN
admet-882	120	2	&	&	CCONJ
admet-882	120	3	dmpk	dmpk	PROPN
admet-882	120	4	9(1	9(1	NUM
admet-882	120	5	)	)	PUNCT
admet-882	120	6	(	(	PUNCT
admet-882	120	7	2021	2021	NUM
admet-882	120	8	)	)	PUNCT
admet-882	120	9	41	41	NUM
admet-882	120	10	-	-	SYM
admet-882	120	11	48	48	NUM
admet-882	120	12	permeability	permeability	NOUN
admet-882	120	13	of	of	ADP
admet-882	120	14	gemcitabine	gemcitabine	NOUN
admet-882	120	15	-	-	PUNCT
admet-882	120	16	cpp6	cpp6	NOUN
admet-882	120	17	conjugates	conjugate	NOUN
admet-882	120	18	in	in	ADP
admet-882	120	19	caco-2	caco-2	NUM
admet-882	120	20	cells	cell	NOUN
admet-882	120	21	doi	doi	NOUN
admet-882	120	22	:	:	PUNCT
admet-882	120	23	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	120	24	47	47	NUM
admet-882	120	25	figure	figure	NOUN
admet-882	120	26	3	3	NUM
admet-882	120	27	.	.	PUNCT
admet-882	121	1	permeability	permeability	NOUN
admet-882	121	2	of	of	ADP
admet-882	121	3	the	the	DET
admet-882	121	4	gem	gem	NOUN
admet-882	121	5	-	-	PUNCT
admet-882	121	6	cpp6	cpp6	NOUN
admet-882	121	7	conjugates	conjugate	NOUN
admet-882	121	8	,	,	PUNCT
admet-882	121	9	expressed	express	VERB
admet-882	121	10	as	as	ADP
admet-882	121	11	the	the	DET
admet-882	121	12	percentage	percentage	NOUN
admet-882	121	13	recovered	recover	VERB
admet-882	121	14	in	in	ADP
admet-882	121	15	the	the	DET
admet-882	121	16	basolateral	basolateral	ADJ
admet-882	121	17	compartment	compartment	NOUN
admet-882	121	18	.	.	PUNCT
admet-882	122	1	table	table	NOUN
admet-882	122	2	1	1	NUM
admet-882	122	3	.	.	PUNCT
admet-882	122	4	physicochemical	physicochemical	ADJ
admet-882	122	5	and	and	CCONJ
admet-882	122	6	in	in	ADP
admet-882	122	7	silico	silico	NOUN
admet-882	122	8	pharmacokinetic	pharmacokinetic	ADJ
admet-882	122	9	data	datum	NOUN
admet-882	122	10	of	of	ADP
admet-882	122	11	cpp6	cpp6	NOUN
admet-882	122	12	-	-	PUNCT
admet-882	122	13	gemcitabine	gemcitabine	NOUN
admet-882	122	14	conjugates	conjugate	NOUN
admet-882	122	15	.	.	PUNCT
admet-882	123	1	peptide	peptide	NOUN
admet-882	123	2	/	/	SYM
admet-882	123	3	conjugate	conjugate	ADJ
admet-882	123	4	mw	mw	NOUN
admet-882	123	5	(	(	PUNCT
admet-882	123	6	g	g	NOUN
admet-882	123	7	/	/	SYM
admet-882	123	8	mol	mol	NOUN
admet-882	123	9	)	)	PUNCT
admet-882	123	10	psa	psa	VERB
admet-882	123	11	a	a	DET
admet-882	123	12	(	(	PUNCT
admet-882	123	13	å	å	PROPN
admet-882	123	14	2	2	NUM
admet-882	123	15	)	)	PUNCT
admet-882	123	16	hbd	hbd	NOUN
admet-882	123	17	peff	peff	PROPN
admet-882	123	18	(	(	PUNCT
admet-882	123	19	cm	cm	NOUN
admet-882	123	20	/	/	SYM
admet-882	123	21	s	s	NOUN
admet-882	123	22	)	)	PUNCT
admet-882	123	23	b	b	PROPN
admet-882	123	24	(	(	PUNCT
admet-882	123	25	x10	x10	NOUN
admet-882	123	26	-6	-6	PROPN
admet-882	123	27	)	)	PUNCT
admet-882	123	28	peff	peff	PROPN
admet-882	123	29	(	(	PUNCT
admet-882	123	30	cm	cm	NOUN
admet-882	123	31	/	/	SYM
admet-882	123	32	s	s	NOUN
admet-882	123	33	)	)	PUNCT
admet-882	123	34	c	c	NOUN
admet-882	123	35	(	(	PUNCT
admet-882	123	36	x10	x10	X
admet-882	123	37	-9	-9	PROPN
admet-882	123	38	)	)	PUNCT
admet-882	123	39	papp	papp	NOUN
admet-882	123	40	(	(	PUNCT
admet-882	123	41	cm	cm	NOUN
admet-882	123	42	/	/	SYM
admet-882	123	43	s	s	NOUN
admet-882	123	44	)	)	PUNCT
admet-882	123	45	(	(	PUNCT
admet-882	123	46	x10	x10	NOUN
admet-882	123	47	-8	-8	NOUN
admet-882	123	48	)	)	PUNCT
admet-882	123	49	gem	gem	NOUN
admet-882	123	50	-	-	PUNCT
admet-882	123	51	cpp6	cpp6	NOUN
admet-882	123	52	-	-	PUNCT
admet-882	123	53	1	1	NUM
admet-882	123	54	1117.29	1117.29	NUM
admet-882	123	55	247.63	247.63	NUM
admet-882	123	56	13	13	NUM
admet-882	123	57	3.19	3.19	NUM
admet-882	123	58	1.31	1.31	NUM
admet-882	123	59	1.326	1.326	NUM
admet-882	123	60	gem	gem	NOUN
admet-882	123	61	-	-	PUNCT
admet-882	123	62	cpp6	cpp6	NOUN
admet-882	123	63	-	-	PUNCT
admet-882	123	64	2	2	NUM
admet-882	123	65	1117.29	1117.29	NUM
admet-882	123	66	247.63	247.63	NUM
admet-882	123	67	13	13	NUM
admet-882	123	68	3.82	3.82	NUM
admet-882	123	69	1.31	1.31	NUM
admet-882	123	70	4.568	4.568	NUM
admet-882	123	71	gem	gem	NOUN
admet-882	123	72	-	-	PUNCT
admet-882	123	73	cpp6	cpp6	NOUN
admet-882	123	74	-	-	PUNCT
admet-882	123	75	3	3	NUM
admet-882	123	76	1087.20	1087.20	NUM
admet-882	123	77	267.86	267.86	NUM
admet-882	123	78	14	14	NUM
admet-882	123	79	2.47	2.47	NUM
admet-882	123	80	0.412	0.412	NUM
admet-882	123	81	1.326	1.326	NUM
admet-882	123	82	a	a	DET
admet-882	123	83	polar	polar	ADJ
admet-882	123	84	surface	surface	NOUN
admet-882	123	85	area	area	NOUN
admet-882	123	86	,	,	PUNCT
admet-882	123	87	predicted	predict	VERB
admet-882	123	88	by	by	ADP
admet-882	123	89	medchem	medchem	NOUN
admet-882	123	90	designer	designer	NOUN
admet-882	123	91	(	(	PUNCT
admet-882	123	92	version	version	NOUN
admet-882	123	93	3.1.0.30	3.1.0.30	PROPN
admet-882	123	94	,	,	PUNCT
admet-882	123	95	simulations	simulation	NOUN
admet-882	123	96	plus	plus	NOUN
admet-882	123	97	,	,	PUNCT
admet-882	123	98	inc	inc	PROPN
admet-882	123	99	.	.	PROPN
admet-882	123	100	,	,	PUNCT
admet-882	123	101	lancaster	lancaster	PROPN
admet-882	123	102	,	,	PUNCT
admet-882	123	103	california	california	PROPN
admet-882	123	104	,	,	PUNCT
admet-882	123	105	usa	usa	PROPN
admet-882	123	106	)	)	PUNCT
admet-882	123	107	;	;	PUNCT
admet-882	123	108	b	b	X
admet-882	123	109	effective	effective	ADJ
admet-882	123	110	permeability	permeability	NOUN
admet-882	123	111	,	,	PUNCT
admet-882	123	112	predicted	predict	VERB
admet-882	123	113	by	by	ADP
admet-882	123	114	gastroplus	gastroplus	ADJ
admet-882	123	115	™	™	PROPN
admet-882	123	116	(	(	PUNCT
admet-882	123	117	version	version	NOUN
admet-882	123	118	9.5	9.5	NUM
admet-882	123	119	,	,	PUNCT
admet-882	123	120	simulations	simulation	NOUN
admet-882	123	121	plus	plus	NOUN
admet-882	123	122	,	,	PUNCT
admet-882	123	123	inc	inc	PROPN
admet-882	123	124	.	.	PROPN
admet-882	123	125	,	,	PUNCT
admet-882	123	126	lancaster	lancaster	PROPN
admet-882	123	127	,	,	PUNCT
admet-882	123	128	california	california	PROPN
admet-882	123	129	,	,	PUNCT
admet-882	123	130	usa	usa	PROPN
admet-882	123	131	)	)	PUNCT
admet-882	123	132	;	;	PUNCT
admet-882	123	133	c	c	X
admet-882	123	134	effective	effective	ADJ
admet-882	123	135	permeability	permeability	NOUN
admet-882	123	136	,	,	PUNCT
admet-882	123	137	calculated	calculate	VERB
admet-882	123	138	from	from	ADP
admet-882	123	139	winiwarter	winiwarter	ADJ
admet-882	123	140	equation	equation	NOUN
admet-882	123	141	:	:	PUNCT
admet-882	123	142	log	log	VERB
admet-882	123	143	peff	peff	NOUN
admet-882	123	144	=	=	SYM
admet-882	123	145	(	(	PUNCT
admet-882	123	146	-2.546	-2.546	PROPN
admet-882	123	147	)	)	PUNCT
admet-882	123	148	–	–	PUNCT
admet-882	123	149	(	(	PUNCT
admet-882	123	150	0.011	0.011	NUM
admet-882	123	151	x	x	SYM
admet-882	123	152	psa	psa	PROPN
admet-882	123	153	)	)	PUNCT
admet-882	123	154	–	–	PUNCT
admet-882	123	155	(	(	PUNCT
admet-882	123	156	0.278	0.278	NUM
admet-882	123	157	x	x	SYM
admet-882	123	158	hbd	hbd	NOUN
admet-882	123	159	)	)	PUNCT
admet-882	123	160	;	;	PUNCT
admet-882	124	1	hbd	hbd	NOUN
admet-882	124	2	:	:	PUNCT
admet-882	124	3	hydrogen	hydrogen	NOUN
admet-882	124	4	bond	bond	NOUN
admet-882	124	5	donors	donor	NOUN
admet-882	124	6	;	;	PUNCT
admet-882	124	7	[	[	X
admet-882	124	8	17	17	NUM
admet-882	124	9	]	]	PUNCT
admet-882	124	10	.	.	PUNCT
admet-882	125	1	conclusions	conclusion	NOUN
admet-882	125	2	the	the	DET
admet-882	125	3	monolayer	monolayer	NOUN
admet-882	125	4	of	of	ADP
admet-882	125	5	caco-2	caco-2	NUM
admet-882	125	6	cells	cell	NOUN
admet-882	125	7	was	be	AUX
admet-882	125	8	a	a	DET
admet-882	125	9	suitable	suitable	ADJ
admet-882	125	10	method	method	NOUN
admet-882	125	11	to	to	PART
admet-882	125	12	study	study	VERB
admet-882	125	13	the	the	DET
admet-882	125	14	permeability	permeability	NOUN
admet-882	125	15	of	of	ADP
admet-882	125	16	the	the	DET
admet-882	125	17	anticancer	anticancer	NOUN
admet-882	125	18	drug	drug	NOUN
admet-882	125	19	gemcitabine	gemcitabine	NOUN
admet-882	125	20	,	,	PUNCT
admet-882	125	21	the	the	DET
admet-882	125	22	cell	cell	NOUN
admet-882	125	23	-	-	PUNCT
admet-882	125	24	penetrating	penetrate	VERB
admet-882	125	25	hexapeptides	hexapeptide	NOUN
admet-882	125	26	(	(	PUNCT
admet-882	125	27	cpp6	cpp6	PROPN
admet-882	125	28	)	)	PUNCT
admet-882	125	29	and	and	CCONJ
admet-882	125	30	the	the	DET
admet-882	125	31	new	new	ADJ
admet-882	125	32	prodrug	prodrug	NOUN
admet-882	125	33	conjugates	conjugate	NOUN
admet-882	125	34	gem	gem	NOUN
admet-882	125	35	-	-	PUNCT
admet-882	125	36	cpp6	cpp6	PROPN
admet-882	125	37	.	.	PUNCT
admet-882	126	1	every	every	DET
admet-882	126	2	cpp6	cpp6	NOUN
admet-882	126	3	and	and	CCONJ
admet-882	126	4	gem	gem	NOUN
admet-882	126	5	-	-	PUNCT
admet-882	126	6	cpp6	cpp6	NOUN
admet-882	126	7	conjugate	conjugate	NOUN
admet-882	126	8	was	be	AUX
admet-882	126	9	able	able	ADJ
admet-882	126	10	to	to	PART
admet-882	126	11	cross	cross	VERB
admet-882	126	12	this	this	DET
admet-882	126	13	monolayer	monolayer	NOUN
admet-882	126	14	,	,	PUNCT
admet-882	126	15	suggesting	suggest	VERB
admet-882	126	16	their	their	PRON
admet-882	126	17	potential	potential	NOUN
admet-882	126	18	as	as	ADP
admet-882	126	19	drug	drug	NOUN
admet-882	126	20	delivery	delivery	NOUN
admet-882	126	21	systems	system	NOUN
admet-882	126	22	.	.	PUNCT
admet-882	127	1	in	in	ADP
admet-882	127	2	agreement	agreement	NOUN
admet-882	127	3	with	with	ADP
admet-882	127	4	previous	previous	ADJ
admet-882	127	5	reports	report	NOUN
admet-882	127	6	,	,	PUNCT
admet-882	127	7	the	the	DET
admet-882	127	8	position	position	NOUN
admet-882	127	9	of	of	ADP
admet-882	127	10	the	the	DET
admet-882	127	11	trp	trp	PROPN
admet-882	127	12	residue	residue	NOUN
admet-882	127	13	was	be	AUX
admet-882	127	14	a	a	DET
admet-882	127	15	determinant	determinant	ADJ
admet-882	127	16	factor	factor	NOUN
admet-882	127	17	influencing	influence	VERB
admet-882	127	18	the	the	DET
admet-882	127	19	permeability	permeability	NOUN
admet-882	127	20	of	of	ADP
admet-882	127	21	the	the	DET
admet-882	127	22	cpp6	cpp6	NOUN
admet-882	127	23	and	and	CCONJ
admet-882	127	24	gem	gem	NOUN
admet-882	127	25	-	-	PUNCT
admet-882	127	26	cpp6	cpp6	NOUN
admet-882	127	27	conjugates	conjugate	NOUN
admet-882	127	28	.	.	PUNCT
admet-882	128	1	amongst	amongst	ADP
admet-882	128	2	the	the	DET
admet-882	128	3	evaluated	evaluate	VERB
admet-882	128	4	compounds	compound	NOUN
admet-882	128	5	,	,	PUNCT
admet-882	128	6	cpp6	cpp6	PROPN
admet-882	128	7	-	-	PUNCT
admet-882	128	8	2	2	NUM
admet-882	128	9	and	and	CCONJ
admet-882	128	10	the	the	DET
admet-882	128	11	respective	respective	ADJ
admet-882	128	12	gem	gem	NOUN
admet-882	128	13	-	-	PUNCT
admet-882	128	14	cpp6	cpp6	NOUN
admet-882	128	15	-	-	PUNCT
admet-882	128	16	2	2	NUM
admet-882	128	17	conjugate	conjugate	NOUN
admet-882	128	18	showed	show	VERB
admet-882	128	19	the	the	DET
admet-882	128	20	highest	high	ADJ
admet-882	128	21	permeability	permeability	NOUN
admet-882	128	22	,	,	PUNCT
admet-882	128	23	crossing	cross	VERB
admet-882	128	24	the	the	DET
admet-882	128	25	cell	cell	NOUN
admet-882	128	26	monolayer	monolayer	NOUN
admet-882	128	27	to	to	ADP
admet-882	128	28	a	a	DET
admet-882	128	29	greater	great	ADJ
admet-882	128	30	extent	extent	NOUN
admet-882	128	31	.	.	PUNCT
admet-882	129	1	this	this	DET
admet-882	129	2	data	datum	NOUN
admet-882	129	3	puts	put	VERB
admet-882	129	4	forward	forward	ADV
admet-882	129	5	this	this	DET
admet-882	129	6	conjugate	conjugate	NOUN
admet-882	129	7	as	as	ADP
admet-882	129	8	a	a	DET
admet-882	129	9	lead	lead	NOUN
admet-882	129	10	for	for	ADP
admet-882	129	11	further	further	ADJ
admet-882	129	12	studies	study	NOUN
admet-882	129	13	and	and	CCONJ
admet-882	129	14	as	as	ADP
admet-882	129	15	the	the	DET
admet-882	129	16	most	most	ADV
admet-882	129	17	promising	promising	ADJ
admet-882	129	18	for	for	ADP
admet-882	129	19	potential	potential	ADJ
admet-882	129	20	clinical	clinical	ADJ
admet-882	129	21	application	application	NOUN
admet-882	129	22	.	.	PUNCT
admet-882	130	1	acknowledgements	acknowledgement	NOUN
admet-882	130	2	this	this	DET
admet-882	130	3	work	work	NOUN
admet-882	130	4	was	be	AUX
admet-882	130	5	financed	finance	VERB
admet-882	130	6	by	by	ADP
admet-882	130	7	feder	feder	PROPN
admet-882	130	8	–	–	PUNCT
admet-882	130	9	fundo	fundo	PROPN
admet-882	130	10	europeu	europeu	PROPN
admet-882	130	11	de	de	PROPN
admet-882	130	12	desenvolvimento	desenvolvimento	PROPN
admet-882	130	13	regional	regional	NOUN
admet-882	130	14	through	through	ADP
admet-882	130	15	the	the	DET
admet-882	130	16	compete	compete	NOUN
admet-882	130	17	2020	2020	NUM
admet-882	130	18	–	–	PUNCT
admet-882	130	19	operational	operational	ADJ
admet-882	130	20	programme	programme	NOUN
admet-882	130	21	for	for	ADP
admet-882	130	22	competitiveness	competitiveness	NOUN
admet-882	130	23	and	and	CCONJ
admet-882	130	24	internationalization	internationalization	NOUN
admet-882	130	25	(	(	PUNCT
admet-882	130	26	poci	poci	PROPN
admet-882	130	27	)	)	PUNCT
admet-882	130	28	,	,	PUNCT
admet-882	130	29	portugal	portugal	PROPN
admet-882	130	30	2020	2020	NUM
admet-882	130	31	,	,	PUNCT
admet-882	130	32	and	and	CCONJ
admet-882	130	33	by	by	ADP
admet-882	130	34	portuguese	portuguese	ADJ
admet-882	130	35	funds	fund	NOUN
admet-882	130	36	through	through	ADP
admet-882	130	37	fct	fct	NOUN
admet-882	130	38	–	–	PUNCT
admet-882	130	39	fundação	fundação	NOUN
admet-882	130	40	para	para	NOUN
admet-882	130	41	a	a	DET
admet-882	130	42	ciência	ciência	PROPN
admet-882	130	43	e	e	ADP
admet-882	130	44	a	a	DET
admet-882	130	45	tecnologia	tecnologia	NOUN
admet-882	130	46	,	,	PUNCT
admet-882	130	47	in	in	ADP
admet-882	130	48	a	a	DET
admet-882	130	49	framework	framework	NOUN
admet-882	130	50	of	of	ADP
admet-882	130	51	cintesis	cintesis	NOUN
admet-882	130	52	,	,	PUNCT
admet-882	130	53	r&d	r&d	NOUN
admet-882	130	54	unit	unit	NOUN
admet-882	130	55	(	(	PUNCT
admet-882	130	56	reference	reference	NOUN
admet-882	130	57	uidb/4255/2020	uidb/4255/2020	NOUN
admet-882	130	58	)	)	PUNCT
admet-882	130	59	.	.	PUNCT
admet-882	131	1	n.v	n.v	PROPN
admet-882	131	2	.	.	PROPN
admet-882	132	1	also	also	ADV
admet-882	132	2	thanks	thank	NOUN
admet-882	132	3	support	support	VERB
admet-882	132	4	fct	fct	NOUN
admet-882	132	5	and	and	CCONJ
admet-882	132	6	feder	feder	PROPN
admet-882	132	7	(	(	PUNCT
admet-882	132	8	european	european	PROPN
admet-882	132	9	union	union	PROPN
admet-882	132	10	)	)	PUNCT
admet-882	132	11	,	,	PUNCT
admet-882	132	12	award	award	NOUN
admet-882	132	13	number	number	NOUN
admet-882	132	14	if/00092/2014	if/00092/2014	PRON
admet-882	132	15	/	/	SYM
admet-882	132	16	cp1255	cp1255	NOUN
admet-882	132	17	/	/	SYM
admet-882	132	18	ct0004	ct0004	NOUN
admet-882	132	19	.	.	PUNCT
admet-882	133	1	rl	rl	PROPN
admet-882	133	2	thanks	thank	NOUN
admet-882	133	3	fct	fct	PROPN
admet-882	133	4	through	through	ADP
admet-882	133	5	grant	grant	PROPN
admet-882	133	6	uid	uid	PROPN
admet-882	133	7	/	/	SYM
admet-882	133	8	qui/50006/2019	qui/50006/2019	PROPN
admet-882	133	9	(	(	PUNCT
admet-882	133	10	laqvrequimte	laqvrequimte	PROPN
admet-882	133	11	)	)	PUNCT
admet-882	133	12	.	.	PUNCT
admet-882	134	1	af	af	PROPN
admet-882	134	2	thanks	thank	NOUN
admet-882	134	3	fct	fct	NOUN
admet-882	134	4	for	for	ADP
admet-882	134	5	a	a	DET
admet-882	134	6	doctoral	doctoral	ADJ
admet-882	134	7	fellowship	fellowship	NOUN
admet-882	134	8	(	(	PUNCT
admet-882	134	9	pd	pd	NOUN
admet-882	134	10	/	/	SYM
admet-882	134	11	bd/135120/2017	bd/135120/2017	PROPN
admet-882	134	12	)	)	PUNCT
admet-882	134	13	.	.	PUNCT
admet-882	135	1	the	the	DET
admet-882	135	2	contents	content	NOUN
admet-882	135	3	of	of	ADP
admet-882	135	4	this	this	DET
admet-882	135	5	article	article	NOUN
admet-882	135	6	are	be	AUX
admet-882	135	7	solely	solely	ADV
admet-882	135	8	the	the	DET
admet-882	135	9	responsibility	responsibility	NOUN
admet-882	135	10	of	of	ADP
admet-882	135	11	the	the	DET
admet-882	135	12	authors	author	NOUN
admet-882	135	13	and	and	CCONJ
admet-882	135	14	do	do	AUX
admet-882	135	15	not	not	PART
admet-882	135	16	necessarily	necessarily	ADV
admet-882	135	17	represent	represent	VERB
admet-882	135	18	the	the	DET
admet-882	135	19	official	official	ADJ
admet-882	135	20	view	view	NOUN
admet-882	135	21	of	of	ADP
admet-882	135	22	the	the	DET
admet-882	135	23	fct	fct	NOUN
admet-882	135	24	.	.	PUNCT
admet-882	136	1	conflict	conflict	NOUN
admet-882	136	2	of	of	ADP
admet-882	136	3	interest	interest	NOUN
admet-882	136	4	:	:	PUNCT
admet-882	136	5	on	on	ADP
admet-882	136	6	behalf	behalf	NOUN
admet-882	136	7	of	of	ADP
admet-882	136	8	all	all	DET
admet-882	136	9	authors	author	NOUN
admet-882	136	10	,	,	PUNCT
admet-882	136	11	the	the	DET
admet-882	136	12	corresponding	corresponding	ADJ
admet-882	136	13	author	author	NOUN
admet-882	136	14	states	state	VERB
admet-882	136	15	that	that	SCONJ
admet-882	136	16	there	there	PRON
admet-882	136	17	is	be	VERB
admet-882	136	18	no	no	DET
admet-882	136	19	conflict	conflict	NOUN
admet-882	136	20	of	of	ADP
admet-882	136	21	interest	interest	NOUN
admet-882	136	22	.	.	PUNCT
admet-882	137	1	http://dx.doi.org/10.5599/admet.882	http://dx.doi.org/10.5599/admet.882	PROPN
admet-882	137	2	n.	n.	PROPN
admet-882	137	3	vale	vale	PROPN
admet-882	137	4	et	et	PROPN
admet-882	137	5	al	al	PROPN
admet-882	137	6	.	.	PROPN
admet-882	137	7	admet	admet	PROPN
admet-882	137	8	&	&	CCONJ
admet-882	137	9	dmpk	dmpk	PROPN
admet-882	137	10	9(1	9(1	NUM
admet-882	137	11	)	)	PUNCT
admet-882	137	12	(	(	PUNCT
admet-882	137	13	2021	2021	NUM
admet-882	137	14	)	)	PUNCT
admet-882	137	15	41	41	NUM
admet-882	137	16	-	-	SYM
admet-882	137	17	48	48	NUM
admet-882	137	18	48	48	NUM
admet-882	137	19	references	reference	NOUN
admet-882	137	20	[	[	X
admet-882	137	21	1	1	NUM
admet-882	137	22	]	]	X
admet-882	137	23	global	global	ADJ
admet-882	137	24	cancer	cancer	NOUN
admet-882	137	25	burden	burden	NOUN
admet-882	137	26	in	in	ADP
admet-882	137	27	2018	2018	NUM
admet-882	137	28	(	(	PUNCT
admet-882	137	29	globocan	globocan	PROPN
admet-882	137	30	2018	2018	NUM
admet-882	137	31	database	database	NOUN
admet-882	137	32	,	,	PUNCT
admet-882	137	33	international	international	ADJ
admet-882	137	34	agency	agency	NOUN
admet-882	137	35	for	for	ADP
admet-882	137	36	research	research	NOUN
admet-882	137	37	on	on	ADP
admet-882	137	38	cancer	cancer	NOUN
admet-882	137	39	)	)	PUNCT
admet-882	137	40	.	.	PUNCT
admet-882	138	1	https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf	https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf	PROPN
admet-882	138	2	(	(	PUNCT
admet-882	138	3	accessed	access	VERB
admet-882	138	4	june	june	PROPN
admet-882	138	5	10	10	NUM
admet-882	138	6	,	,	PUNCT
admet-882	138	7	2020	2020	NUM
admet-882	138	8	)	)	PUNCT
admet-882	138	9	.	.	PUNCT
admet-882	139	1	[	[	X
admet-882	139	2	2	2	NUM
admet-882	139	3	]	]	PUNCT
admet-882	139	4	a.	a.	PROPN
admet-882	139	5	wong	wong	PROPN
admet-882	139	6	,	,	PUNCT
admet-882	139	7	r.a	r.a	PROPN
admet-882	139	8	.	.	PROPN
admet-882	139	9	soo	soo	PROPN
admet-882	139	10	,	,	PUNCT
admet-882	139	11	w.-p	w.-p	PROPN
admet-882	139	12	.	.	PUNCT
admet-882	140	1	yong	yong	PROPN
admet-882	140	2	,	,	PUNCT
admet-882	140	3	f.	f.	PROPN
admet-882	140	4	innocenti	innocenti	PROPN
admet-882	140	5	.	.	PUNCT
admet-882	141	1	clinical	clinical	ADJ
admet-882	141	2	pharmacology	pharmacology	NOUN
admet-882	141	3	and	and	CCONJ
admet-882	141	4	pharmacogenetics	pharmacogenetic	NOUN
admet-882	141	5	of	of	ADP
admet-882	141	6	gemcitabine	gemcitabine	NOUN
admet-882	141	7	.	.	PUNCT
admet-882	142	1	drug	drug	NOUN
admet-882	142	2	metabolism	metabolism	NOUN
admet-882	142	3	reviews	review	NOUN
admet-882	142	4	41	41	NUM
admet-882	142	5	(	(	PUNCT
admet-882	142	6	2009	2009	NUM
admet-882	142	7	)	)	PUNCT
admet-882	142	8	77	77	NUM
admet-882	142	9	-	-	SYM
admet-882	142	10	88	88	NUM
admet-882	142	11	.	.	PUNCT
admet-882	143	1	[	[	X
admet-882	143	2	3	3	X
admet-882	143	3	]	]	X
admet-882	143	4	e.	e.	PROPN
admet-882	143	5	mini	mini	PROPN
admet-882	143	6	,	,	PUNCT
admet-882	143	7	s.	s.	PROPN
admet-882	143	8	nobili	nobili	PROPN
admet-882	143	9	,	,	PUNCT
admet-882	143	10	b.	b.	PROPN
admet-882	143	11	caciagli	caciagli	PROPN
admet-882	143	12	,	,	PUNCT
admet-882	143	13	i.	i.	PROPN
admet-882	143	14	landini	landini	PROPN
admet-882	143	15	,	,	PUNCT
admet-882	143	16	t.	t.	PROPN
admet-882	143	17	mazzei	mazzei	PROPN
admet-882	143	18	.	.	PUNCT
admet-882	143	19	cellular	cellular	ADJ
admet-882	143	20	pharmacology	pharmacology	NOUN
admet-882	143	21	of	of	ADP
admet-882	143	22	gemcitabine	gemcitabine	NOUN
admet-882	143	23	.	.	PUNCT
admet-882	144	1	annals	annal	NOUN
admet-882	144	2	of	of	ADP
admet-882	144	3	oncology	oncology	NOUN
admet-882	144	4	17	17	NUM
admet-882	144	5	(	(	PUNCT
admet-882	144	6	2006	2006	NUM
admet-882	144	7	)	)	PUNCT
admet-882	144	8	7	7	NUM
admet-882	144	9	-	-	SYM
admet-882	144	10	12	12	NUM
admet-882	144	11	.	.	PUNCT
admet-882	145	1	[	[	X
admet-882	145	2	4	4	X
admet-882	145	3	]	]	X
admet-882	145	4	e.	e.	PROPN
admet-882	145	5	moysan	moysan	PROPN
admet-882	145	6	,	,	PUNCT
admet-882	145	7	g.	g.	PROPN
admet-882	145	8	bastiat	bastiat	PROPN
admet-882	145	9	,	,	PUNCT
admet-882	145	10	j.-p	j.-p	PROPN
admet-882	145	11	.	.	PUNCT
admet-882	146	1	benoit	benoit	PROPN
admet-882	146	2	.	.	PUNCT
admet-882	147	1	gemcitabine	gemcitabine	NOUN
admet-882	147	2	versus	versus	ADP
admet-882	147	3	modified	modified	ADJ
admet-882	147	4	gemcitabine	gemcitabine	NOUN
admet-882	147	5	:	:	PUNCT
admet-882	147	6	a	a	DET
admet-882	147	7	review	review	NOUN
admet-882	147	8	of	of	ADP
admet-882	147	9	several	several	ADJ
admet-882	147	10	promising	promising	ADJ
admet-882	147	11	chemical	chemical	NOUN
admet-882	147	12	modifications	modification	NOUN
admet-882	147	13	.	.	PUNCT
admet-882	148	1	molecular	molecular	ADJ
admet-882	148	2	pharmaceutics	pharmaceutic	NOUN
admet-882	148	3	10	10	NUM
admet-882	148	4	(	(	PUNCT
admet-882	148	5	2013	2013	NUM
admet-882	148	6	)	)	PUNCT
admet-882	148	7	430	430	NUM
admet-882	148	8	-	-	SYM
admet-882	148	9	444	444	NUM
admet-882	148	10	.	.	PUNCT
admet-882	149	1	[	[	X
admet-882	149	2	5	5	NUM
admet-882	149	3	]	]	PUNCT
admet-882	149	4	c.	c.	PROPN
admet-882	149	5	correia	correia	PROPN
admet-882	149	6	,	,	PUNCT
admet-882	149	7	c.p.r	c.p.r	NOUN
admet-882	149	8	.	.	PUNCT
admet-882	150	1	xavier	xavier	PROPN
admet-882	150	2	,	,	PUNCT
admet-882	150	3	d.	d.	PROPN
admet-882	150	4	duarte	duarte	PROPN
admet-882	150	5	,	,	PUNCT
admet-882	150	6	a.	a.	PROPN
admet-882	150	7	ferreira	ferreira	PROPN
admet-882	150	8	,	,	PUNCT
admet-882	150	9	s.	s.	PROPN
admet-882	150	10	moreira	moreira	PROPN
admet-882	150	11	,	,	PUNCT
admet-882	150	12	m.h	m.h	PROPN
admet-882	150	13	.	.	PROPN
admet-882	150	14	vasconcelos	vasconcelos	PROPN
admet-882	150	15	,	,	PUNCT
admet-882	150	16	n.	n.	PROPN
admet-882	150	17	vale	vale	NOUN
admet-882	150	18	.	.	PUNCT
admet-882	151	1	development	development	NOUN
admet-882	151	2	of	of	ADP
admet-882	151	3	potent	potent	ADJ
admet-882	151	4	cpp6	cpp6	NOUN
admet-882	151	5	-	-	PUNCT
admet-882	151	6	gemcitabine	gemcitabine	NOUN
admet-882	151	7	conjugates	conjugate	NOUN
admet-882	151	8	against	against	ADP
admet-882	151	9	human	human	ADJ
admet-882	151	10	prostate	prostate	NOUN
admet-882	151	11	cancer	cancer	NOUN
admet-882	151	12	cell	cell	NOUN
admet-882	151	13	line	line	NOUN
admet-882	151	14	(	(	PUNCT
admet-882	151	15	pc-3	pc-3	NOUN
admet-882	151	16	)	)	PUNCT
admet-882	151	17	.	.	PUNCT
admet-882	152	1	rsc	rsc	PROPN
admet-882	152	2	medicinal	medicinal	ADJ
admet-882	152	3	chemistry	chemistry	PROPN
admet-882	152	4	11	11	NUM
admet-882	152	5	(	(	PUNCT
admet-882	152	6	2020	2020	NUM
admet-882	152	7	)	)	PUNCT
admet-882	152	8	268	268	NUM
admet-882	152	9	-	-	SYM
admet-882	152	10	273	273	NUM
admet-882	152	11	.	.	PUNCT
admet-882	153	1	[	[	X
admet-882	153	2	6	6	NUM
admet-882	153	3	]	]	X
admet-882	153	4	n.	n.	NOUN
admet-882	153	5	vale	vale	NOUN
admet-882	153	6	,	,	PUNCT
admet-882	153	7	a.	a.	PROPN
admet-882	153	8	ferreira	ferreira	PROPN
admet-882	153	9	,	,	PUNCT
admet-882	153	10	i.	i.	PROPN
admet-882	153	11	fernandes	fernandes	PROPN
admet-882	153	12	,	,	PUNCT
admet-882	153	13	c.	c.	PROPN
admet-882	153	14	alves	alves	PROPN
admet-882	153	15	,	,	PUNCT
admet-882	153	16	m.j	m.j	PROPN
admet-882	153	17	.	.	PROPN
admet-882	153	18	araujo	araujo	PROPN
admet-882	153	19	,	,	PUNCT
admet-882	153	20	n.	n.	PROPN
admet-882	153	21	mateus	mateus	PROPN
admet-882	153	22	,	,	PUNCT
admet-882	153	23	p.	p.	PROPN
admet-882	153	24	gomes	gome	NOUN
admet-882	153	25	.	.	PUNCT
admet-882	154	1	gemcitabine	gemcitabine	NOUN
admet-882	154	2	antiproliferative	antiproliferative	NOUN
admet-882	154	3	activity	activity	NOUN
admet-882	154	4	significantly	significantly	ADV
admet-882	154	5	enhanced	enhance	VERB
admet-882	154	6	upon	upon	SCONJ
admet-882	154	7	conjugation	conjugation	NOUN
admet-882	154	8	with	with	ADP
admet-882	154	9	cell	cell	NOUN
admet-882	154	10	-	-	PUNCT
admet-882	154	11	penetrating	penetrate	VERB
admet-882	154	12	peptides	peptide	NOUN
admet-882	154	13	.	.	PUNCT
admet-882	155	1	bioorganic	bioorganic	ADJ
admet-882	155	2	and	and	CCONJ
admet-882	155	3	medicinal	medicinal	ADJ
admet-882	155	4	chemistry	chemistry	NOUN
admet-882	155	5	27	27	NUM
admet-882	155	6	(	(	PUNCT
admet-882	155	7	2017	2017	NUM
admet-882	155	8	)	)	PUNCT
admet-882	155	9	2898	2898	NUM
admet-882	155	10	-	-	SYM
admet-882	155	11	2901	2901	NUM
admet-882	155	12	.	.	PUNCT
admet-882	156	1	[	[	X
admet-882	156	2	7	7	X
admet-882	156	3	]	]	PUNCT
admet-882	156	4	k.	k.	PROPN
admet-882	156	5	kachel	kachel	PROPN
admet-882	156	6	,	,	PUNCT
admet-882	156	7	e.	e.	PROPN
admet-882	156	8	asuncion	asuncion	PROPN
admet-882	156	9	-	-	PUNCT
admet-882	156	10	punzalan	punzalan	PROPN
admet-882	156	11	,	,	PUNCT
admet-882	156	12	e.	e.	PROPN
admet-882	156	13	london	london	PROPN
admet-882	156	14	.	.	PUNCT
admet-882	157	1	anchoring	anchoring	NOUN
admet-882	157	2	of	of	ADP
admet-882	157	3	tryptophan	tryptophan	NOUN
admet-882	157	4	and	and	CCONJ
admet-882	157	5	tyrosine	tyrosine	NOUN
admet-882	157	6	analogs	analog	NOUN
admet-882	157	7	at	at	ADP
admet-882	157	8	the	the	DET
admet-882	157	9	hydrocarbon	hydrocarbon	NOUN
admet-882	157	10	-	-	PUNCT
admet-882	157	11	polar	polar	ADJ
admet-882	157	12	boundary	boundary	NOUN
admet-882	157	13	in	in	ADP
admet-882	157	14	model	model	NOUN
admet-882	157	15	membrane	membrane	NOUN
admet-882	157	16	vesicles	vesicle	NOUN
admet-882	157	17	.	.	PUNCT
admet-882	158	1	biochemistry	biochemistry	NOUN
admet-882	158	2	34	34	NUM
admet-882	158	3	(	(	PUNCT
admet-882	158	4	1995	1995	NUM
admet-882	158	5	)	)	PUNCT
admet-882	158	6	15475	15475	NUM
admet-882	158	7	-	-	SYM
admet-882	158	8	15479	15479	NUM
admet-882	158	9	.	.	PUNCT
admet-882	159	1	[	[	X
admet-882	159	2	8	8	NUM
admet-882	159	3	]	]	X
admet-882	159	4	d.j	d.j	PROPN
admet-882	159	5	.	.	PROPN
admet-882	159	6	schibli	schibli	PROPN
admet-882	159	7	,	,	PUNCT
admet-882	159	8	r.f	r.f	PROPN
admet-882	159	9	.	.	PROPN
admet-882	159	10	epand	epand	PROPN
admet-882	159	11	,	,	PUNCT
admet-882	159	12	h.j	h.j	PROPN
admet-882	159	13	.	.	PROPN
admet-882	159	14	vogel	vogel	PROPN
admet-882	159	15	,	,	PUNCT
admet-882	159	16	r.m	r.m	PROPN
admet-882	159	17	.	.	PROPN
admet-882	159	18	epand	epand	PROPN
admet-882	159	19	.	.	PUNCT
admet-882	159	20	tryptophan	tryptophan	NOUN
admet-882	159	21	-	-	PUNCT
admet-882	159	22	rich	rich	ADJ
admet-882	159	23	antimicrobial	antimicrobial	ADJ
admet-882	159	24	peptides	peptide	NOUN
admet-882	159	25	:	:	PUNCT
admet-882	159	26	comparative	comparative	ADJ
admet-882	159	27	properties	property	NOUN
admet-882	159	28	and	and	CCONJ
admet-882	159	29	membrane	membrane	NOUN
admet-882	159	30	interactions	interaction	NOUN
admet-882	159	31	.	.	PUNCT
admet-882	160	1	biochemistry	biochemistry	NOUN
admet-882	160	2	cell	cell	NOUN
admet-882	160	3	biology	biology	NOUN
admet-882	160	4	80	80	NUM
admet-882	160	5	(	(	PUNCT
admet-882	160	6	2002	2002	NUM
admet-882	160	7	)	)	PUNCT
admet-882	160	8	667	667	NUM
admet-882	160	9	-	-	SYM
admet-882	160	10	677	677	NUM
admet-882	160	11	.	.	PUNCT
admet-882	161	1	[	[	X
admet-882	161	2	9	9	NUM
admet-882	161	3	]	]	X
admet-882	161	4	i.d	i.d	PROPN
admet-882	161	5	.	.	PROPN
admet-882	161	6	angelis	angelis	PROPN
admet-882	161	7	,	,	PUNCT
admet-882	161	8	l.	l.	PROPN
admet-882	161	9	turco	turco	PROPN
admet-882	161	10	.	.	PUNCT
admet-882	162	1	caco‐2	caco‐2	PROPN
admet-882	162	2	cells	cell	NOUN
admet-882	162	3	as	as	ADP
admet-882	162	4	a	a	DET
admet-882	162	5	model	model	NOUN
admet-882	162	6	for	for	ADP
admet-882	162	7	intestinal	intestinal	ADJ
admet-882	162	8	absorption	absorption	NOUN
admet-882	162	9	.	.	PUNCT
admet-882	163	1	current	current	ADJ
admet-882	163	2	protocols	protocol	NOUN
admet-882	163	3	in	in	ADP
admet-882	163	4	toxicology	toxicology	NOUN
admet-882	163	5	47	47	NUM
admet-882	163	6	(	(	PUNCT
admet-882	163	7	2011	2011	NUM
admet-882	163	8	)	)	PUNCT
admet-882	163	9	20.6.1	20.6.1	PROPN
admet-882	163	10	-	-	PUNCT
admet-882	163	11	20.6.15	20.6.15	NUM
admet-882	163	12	.	.	PUNCT
admet-882	164	1	[	[	X
admet-882	164	2	10	10	NUM
admet-882	164	3	]	]	X
admet-882	164	4	u.s	u.s	PROPN
admet-882	164	5	.	.	PROPN
admet-882	164	6	department	department	PROPN
admet-882	164	7	of	of	ADP
admet-882	164	8	health	health	PROPN
admet-882	164	9	and	and	CCONJ
admet-882	164	10	human	human	ADJ
admet-882	164	11	services	service	NOUN
admet-882	164	12	,	,	PUNCT
admet-882	164	13	food	food	NOUN
admet-882	164	14	and	and	CCONJ
admet-882	164	15	drug	drug	NOUN
admet-882	164	16	administration	administration	NOUN
admet-882	164	17	,	,	PUNCT
admet-882	164	18	center	center	NOUN
admet-882	164	19	for	for	ADP
admet-882	164	20	drug	drug	NOUN
admet-882	164	21	evaluation	evaluation	NOUN
admet-882	164	22	and	and	CCONJ
admet-882	164	23	research	research	NOUN
admet-882	164	24	(	(	PUNCT
admet-882	164	25	cder	cder	NOUN
admet-882	164	26	)	)	PUNCT
admet-882	164	27	.	.	PUNCT
admet-882	165	1	waiver	waiver	NOUN
admet-882	165	2	of	of	ADP
admet-882	165	3	in	in	ADP
admet-882	165	4	vivo	vivo	ADJ
admet-882	165	5	bioavailability	bioavailability	NOUN
admet-882	165	6	and	and	CCONJ
admet-882	165	7	bioequivalence	bioequivalence	NOUN
admet-882	165	8	studies	study	NOUN
admet-882	165	9	for	for	ADP
admet-882	165	10	immediate	immediate	ADJ
admet-882	165	11	-	-	PUNCT
admet-882	165	12	release	release	NOUN
admet-882	165	13	solid	solid	ADJ
admet-882	165	14	oral	oral	ADJ
admet-882	165	15	dosage	dosage	NOUN
admet-882	165	16	forms	form	NOUN
admet-882	165	17	based	base	VERB
admet-882	165	18	on	on	ADP
admet-882	165	19	a	a	DET
admet-882	165	20	biopharmaceutics	biopharmaceutics	NOUN
admet-882	165	21	classification	classification	NOUN
admet-882	165	22	system	system	NOUN
admet-882	165	23	.	.	PUNCT
admet-882	166	1	december	december	PROPN
admet-882	166	2	2017	2017	NUM
admet-882	166	3	,	,	PUNCT
admet-882	166	4	biopharmaceutics	biopharmaceutics	NOUN
admet-882	166	5	.	.	PUNCT
admet-882	167	1	[	[	X
admet-882	167	2	11	11	NUM
admet-882	167	3	]	]	PUNCT
admet-882	167	4	i.	i.	NOUN
admet-882	167	5	hubatsch	hubatsch	PROPN
admet-882	167	6	,	,	PUNCT
admet-882	167	7	e.g.	e.g.	ADV
admet-882	167	8	ragnarsson	ragnarsson	NOUN
admet-882	167	9	,	,	PUNCT
admet-882	167	10	p.	p.	PROPN
admet-882	167	11	artursson	artursson	PROPN
admet-882	167	12	.	.	PUNCT
admet-882	168	1	determination	determination	NOUN
admet-882	168	2	of	of	ADP
admet-882	168	3	drug	drug	NOUN
admet-882	168	4	permeability	permeability	NOUN
admet-882	168	5	and	and	CCONJ
admet-882	168	6	prediction	prediction	NOUN
admet-882	168	7	of	of	ADP
admet-882	168	8	drug	drug	NOUN
admet-882	168	9	absorption	absorption	NOUN
admet-882	168	10	in	in	ADP
admet-882	168	11	caco-2	caco-2	NUM
admet-882	168	12	monolayers	monolayer	NOUN
admet-882	168	13	.	.	PUNCT
admet-882	169	1	nature	nature	NOUN
admet-882	169	2	protocols	protocol	NOUN
admet-882	169	3	2	2	NUM
admet-882	169	4	(	(	PUNCT
admet-882	169	5	2007	2007	NUM
admet-882	169	6	)	)	PUNCT
admet-882	169	7	2111	2111	NUM
admet-882	169	8	-	-	SYM
admet-882	169	9	2119	2119	NUM
admet-882	169	10	.	.	PUNCT
admet-882	170	1	[	[	X
admet-882	170	2	12	12	NUM
admet-882	170	3	]	]	X
admet-882	170	4	h.a	h.a	PROPN
admet-882	170	5	.	.	PROPN
admet-882	170	6	rydberg	rydberg	PROPN
admet-882	170	7	,	,	PUNCT
admet-882	170	8	m.	m.	PROPN
admet-882	170	9	matson	matson	PROPN
admet-882	170	10	,	,	PUNCT
admet-882	170	11	h.l	h.l	PROPN
admet-882	170	12	.	.	PROPN
admet-882	170	13	åmand	åmand	PROPN
admet-882	170	14	,	,	PUNCT
admet-882	170	15	e.k	e.k	PROPN
admet-882	170	16	.	.	PROPN
admet-882	170	17	esbjorner	esbjorner	PROPN
admet-882	170	18	,	,	PUNCT
admet-882	170	19	b.	b.	PROPN
admet-882	170	20	nordén	nordén	PROPN
admet-882	170	21	.	.	PUNCT
admet-882	171	1	effects	effect	NOUN
admet-882	171	2	of	of	ADP
admet-882	171	3	tryptophan	tryptophan	NOUN
admet-882	171	4	content	content	NOUN
admet-882	171	5	and	and	CCONJ
admet-882	171	6	backbone	backbone	NOUN
admet-882	171	7	spacing	spacing	NOUN
admet-882	171	8	on	on	ADP
admet-882	171	9	the	the	DET
admet-882	171	10	uptake	uptake	ADJ
admet-882	171	11	efficiency	efficiency	NOUN
admet-882	171	12	of	of	ADP
admet-882	171	13	cell	cell	NOUN
admet-882	171	14	-	-	PUNCT
admet-882	171	15	penetrating	penetrate	VERB
admet-882	171	16	peptides	peptide	NOUN
admet-882	171	17	.	.	PUNCT
admet-882	172	1	biochemistry	biochemistry	NOUN
admet-882	172	2	51	51	NUM
admet-882	172	3	(	(	PUNCT
admet-882	172	4	2012	2012	NUM
admet-882	172	5	)	)	PUNCT
admet-882	172	6	55315539	55315539	NUM
admet-882	172	7	.	.	PUNCT
admet-882	173	1	[	[	X
admet-882	173	2	13	13	NUM
admet-882	173	3	]	]	X
admet-882	173	4	d.i	d.i	PROPN
admet-882	173	5	.	.	PROPN
admet-882	173	6	chan	chan	PROPN
admet-882	173	7	,	,	PUNCT
admet-882	173	8	e.j	e.j	PROPN
admet-882	173	9	.	.	PROPN
admet-882	173	10	prenner	prenner	PROPN
admet-882	173	11	,	,	PUNCT
admet-882	173	12	h.j	h.j	PROPN
admet-882	173	13	.	.	PROPN
admet-882	173	14	vogel	vogel	PROPN
admet-882	173	15	.	.	PUNCT
admet-882	173	16	tryptophan	tryptophan	NOUN
admet-882	173	17	-	-	PUNCT
admet-882	173	18	and	and	CCONJ
admet-882	173	19	arginine	arginine	NOUN
admet-882	173	20	-	-	PUNCT
admet-882	173	21	rich	rich	ADJ
admet-882	173	22	antimicrobial	antimicrobial	ADJ
admet-882	173	23	peptides	peptide	NOUN
admet-882	173	24	:	:	PUNCT
admet-882	173	25	structures	structure	NOUN
admet-882	173	26	and	and	CCONJ
admet-882	173	27	mechanisms	mechanism	NOUN
admet-882	173	28	of	of	ADP
admet-882	173	29	action	action	NOUN
admet-882	173	30	.	.	PUNCT
admet-882	174	1	biochimica	biochimica	PROPN
admet-882	174	2	et	et	PROPN
admet-882	174	3	biophysica	biophysica	PROPN
admet-882	174	4	acta	acta	PROPN
admet-882	174	5	(	(	PUNCT
admet-882	174	6	bba)-biomembranes	bba)-biomembranes	PROPN
admet-882	174	7	1758	1758	NUM
admet-882	174	8	(	(	PUNCT
admet-882	174	9	2006	2006	NUM
admet-882	174	10	)	)	PUNCT
admet-882	174	11	11841202	11841202	NUM
admet-882	174	12	.	.	PUNCT
admet-882	175	1	[	[	X
admet-882	175	2	14	14	NUM
admet-882	175	3	]	]	X
admet-882	175	4	g.	g.	PROPN
admet-882	175	5	trinquier	trinquier	PROPN
admet-882	175	6	,	,	PUNCT
admet-882	175	7	y.-h	y.-h	PROPN
admet-882	175	8	.	.	PUNCT
admet-882	176	1	sanejouand	sanejouand	PROPN
admet-882	176	2	.	.	PUNCT
admet-882	177	1	which	which	DET
admet-882	177	2	effective	effective	ADJ
admet-882	177	3	property	property	NOUN
admet-882	177	4	of	of	ADP
admet-882	177	5	amino	amino	ADJ
admet-882	177	6	acids	acid	NOUN
admet-882	177	7	is	be	AUX
admet-882	177	8	best	well	ADV
admet-882	177	9	preserved	preserve	VERB
admet-882	177	10	by	by	ADP
admet-882	177	11	the	the	DET
admet-882	177	12	genetic	genetic	ADJ
admet-882	177	13	code	code	NOUN
admet-882	177	14	?	?	PUNCT
admet-882	178	1	protein	protein	NOUN
admet-882	178	2	engineering	engineer	VERB
admet-882	178	3	11	11	NUM
admet-882	178	4	(	(	PUNCT
admet-882	178	5	1998	1998	NUM
admet-882	178	6	)	)	PUNCT
admet-882	178	7	153	153	NUM
admet-882	178	8	-	-	SYM
admet-882	178	9	169	169	NUM
admet-882	178	10	.	.	PUNCT
admet-882	179	1	[	[	X
admet-882	179	2	15	15	NUM
admet-882	179	3	]	]	X
admet-882	179	4	w.-m	w.-m	NOUN
admet-882	179	5	.	.	PUNCT
admet-882	180	1	yau	yau	PROPN
admet-882	180	2	,	,	PUNCT
admet-882	180	3	w.c	w.c	PROPN
admet-882	180	4	.	.	PROPN
admet-882	180	5	wimley	wimley	PROPN
admet-882	180	6	,	,	PUNCT
admet-882	180	7	k.	k.	PROPN
admet-882	180	8	gawrisch	gawrisch	PROPN
admet-882	180	9	,	,	PUNCT
admet-882	180	10	s.h	s.h	PROPN
admet-882	180	11	.	.	PROPN
admet-882	180	12	white	white	PROPN
admet-882	180	13	.	.	PUNCT
admet-882	181	1	the	the	DET
admet-882	181	2	preference	preference	NOUN
admet-882	181	3	of	of	ADP
admet-882	181	4	tryptophan	tryptophan	NOUN
admet-882	181	5	for	for	ADP
admet-882	181	6	membrane	membrane	NOUN
admet-882	181	7	interfaces	interface	NOUN
admet-882	181	8	.	.	PUNCT
admet-882	182	1	biochemistry	biochemistry	NOUN
admet-882	182	2	37	37	NUM
admet-882	182	3	(	(	PUNCT
admet-882	182	4	1998	1998	NUM
admet-882	182	5	)	)	PUNCT
admet-882	182	6	14713	14713	NUM
admet-882	182	7	-	-	SYM
admet-882	182	8	14718	14718	NUM
admet-882	182	9	.	.	PUNCT
admet-882	183	1	[	[	X
admet-882	183	2	16	16	NUM
admet-882	183	3	]	]	X
admet-882	183	4	m.-l	m.-l	PROPN
admet-882	183	5	.	.	PUNCT
admet-882	184	1	jobin	jobin	PROPN
admet-882	184	2	,	,	PUNCT
admet-882	184	3	m.	m.	PROPN
admet-882	184	4	blanchet	blanchet	PROPN
admet-882	184	5	,	,	PUNCT
admet-882	184	6	s.	s.	PROPN
admet-882	184	7	henry	henry	PROPN
admet-882	184	8	,	,	PUNCT
admet-882	184	9	s.	s.	PROPN
admet-882	184	10	chaignepain	chaignepain	PROPN
admet-882	184	11	,	,	PUNCT
admet-882	184	12	c.	c.	PROPN
admet-882	184	13	manigand	manigand	PROPN
admet-882	184	14	,	,	PUNCT
admet-882	184	15	s.	s.	PROPN
admet-882	184	16	castano	castano	PROPN
admet-882	184	17	,	,	PUNCT
admet-882	184	18	s.	s.	PROPN
admet-882	184	19	lecomte	lecomte	PROPN
admet-882	184	20	,	,	PUNCT
admet-882	184	21	f.	f.	PROPN
admet-882	184	22	burlina	burlina	PROPN
admet-882	184	23	,	,	PUNCT
admet-882	184	24	s.	s.	PROPN
admet-882	184	25	sagan	sagan	PROPN
admet-882	184	26	,	,	PUNCT
admet-882	184	27	i.d	i.d	PROPN
admet-882	184	28	.	.	PROPN
admet-882	184	29	alves	alves	PROPN
admet-882	184	30	.	.	PUNCT
admet-882	185	1	the	the	DET
admet-882	185	2	role	role	NOUN
admet-882	185	3	of	of	ADP
admet-882	185	4	tryptophans	tryptophan	NOUN
admet-882	185	5	on	on	ADP
admet-882	185	6	the	the	DET
admet-882	185	7	cellular	cellular	ADJ
admet-882	185	8	uptake	uptake	NOUN
admet-882	185	9	and	and	CCONJ
admet-882	185	10	membrane	membrane	NOUN
admet-882	185	11	interaction	interaction	NOUN
admet-882	185	12	of	of	ADP
admet-882	185	13	arginine	arginine	NOUN
admet-882	185	14	-	-	PUNCT
admet-882	185	15	rich	rich	ADJ
admet-882	185	16	cell	cell	NOUN
admet-882	185	17	-	-	PUNCT
admet-882	185	18	penetrating	penetrate	VERB
admet-882	185	19	peptides	peptide	NOUN
admet-882	185	20	.	.	PUNCT
admet-882	186	1	biochimica	biochimica	PROPN
admet-882	186	2	et	et	PROPN
admet-882	186	3	biophysica	biophysica	PROPN
admet-882	186	4	acta	acta	PROPN
admet-882	186	5	(	(	PUNCT
admet-882	186	6	bba)-biomembranes	bba)-biomembranes	PROPN
admet-882	186	7	1848	1848	NUM
admet-882	186	8	(	(	PUNCT
admet-882	186	9	2015	2015	NUM
admet-882	186	10	)	)	PUNCT
admet-882	186	11	593	593	NUM
admet-882	186	12	-	-	SYM
admet-882	186	13	602	602	NUM
admet-882	186	14	.	.	PUNCT
admet-882	187	1	[	[	X
admet-882	187	2	17	17	NUM
admet-882	187	3	]	]	PUNCT
admet-882	187	4	s.	s.	PROPN
admet-882	187	5	winiwarter	winiwarter	PROPN
admet-882	187	6	,	,	PUNCT
admet-882	187	7	n.m	n.m	PROPN
admet-882	187	8	.	.	PROPN
admet-882	187	9	bonham	bonham	PROPN
admet-882	187	10	,	,	PUNCT
admet-882	187	11	f.	f.	PROPN
admet-882	187	12	ax	ax	PROPN
admet-882	187	13	,	,	PUNCT
admet-882	187	14	a.	a.	PROPN
admet-882	187	15	hallberg	hallberg	PROPN
admet-882	187	16	,	,	PUNCT
admet-882	187	17	h.	h.	PROPN
admet-882	187	18	lennernäs	lennernäs	PROPN
admet-882	187	19	,	,	PUNCT
admet-882	187	20	a.	a.	NOUN
admet-882	187	21	karlén	karlén	PROPN
admet-882	187	22	.	.	PUNCT
admet-882	188	1	correlation	correlation	NOUN
admet-882	188	2	of	of	ADP
admet-882	188	3	human	human	ADJ
admet-882	188	4	jejunal	jejunal	ADJ
admet-882	188	5	permeability	permeability	NOUN
admet-882	188	6	(	(	PUNCT
admet-882	188	7	in	in	ADP
admet-882	188	8	vivo	vivo	NOUN
admet-882	188	9	)	)	PUNCT
admet-882	188	10	of	of	ADP
admet-882	188	11	drugs	drug	NOUN
admet-882	188	12	with	with	ADP
admet-882	188	13	experimentally	experimentally	ADV
admet-882	188	14	and	and	CCONJ
admet-882	188	15	theoretically	theoretically	ADV
admet-882	188	16	derived	derive	VERB
admet-882	188	17	parameters	parameter	NOUN
admet-882	188	18	.	.	PUNCT
admet-882	189	1	a	a	DET
admet-882	189	2	multivariate	multivariate	NOUN
admet-882	189	3	data	datum	NOUN
admet-882	189	4	analysis	analysis	NOUN
admet-882	189	5	approach	approach	NOUN
admet-882	189	6	.	.	PUNCT
admet-882	190	1	journal	journal	NOUN
admet-882	190	2	of	of	ADP
admet-882	190	3	medicinal	medicinal	ADJ
admet-882	190	4	chemistry	chemistry	NOUN
admet-882	190	5	41	41	NUM
admet-882	190	6	(	(	PUNCT
admet-882	190	7	1998	1998	NUM
admet-882	190	8	)	)	PUNCT
admet-882	190	9	4939	4939	NUM
admet-882	190	10	-	-	SYM
admet-882	190	11	4949	4949	NUM
admet-882	190	12	.	.	PUNCT
admet-882	191	1	©	©	PROPN
admet-882	191	2	2020	2020	NUM
admet-882	191	3	by	by	ADP
admet-882	191	4	the	the	DET
admet-882	191	5	authors	author	NOUN
admet-882	191	6	;	;	PUNCT
admet-882	191	7	licensee	licensee	PROPN
admet-882	191	8	iapc	iapc	PROPN
admet-882	191	9	,	,	PUNCT
admet-882	191	10	zagreb	zagreb	PROPN
admet-882	191	11	,	,	PUNCT
admet-882	191	12	croatia	croatia	PROPN
admet-882	191	13	.	.	PUNCT
admet-882	192	1	this	this	DET
admet-882	192	2	article	article	NOUN
admet-882	192	3	is	be	AUX
admet-882	192	4	an	an	DET
admet-882	192	5	open	open	ADJ
admet-882	192	6	-	-	PUNCT
admet-882	192	7	access	access	NOUN
admet-882	192	8	article	article	NOUN
admet-882	192	9	distributed	distribute	VERB
admet-882	192	10	under	under	ADP
admet-882	192	11	the	the	DET
admet-882	192	12	terms	term	NOUN
admet-882	192	13	and	and	CCONJ
admet-882	192	14	conditions	condition	NOUN
admet-882	192	15	of	of	ADP
admet-882	192	16	the	the	DET
admet-882	192	17	creative	creative	ADJ
admet-882	192	18	commons	common	NOUN
admet-882	192	19	attribution	attribution	NOUN
admet-882	192	20	license	license	NOUN
admet-882	192	21	(	(	PUNCT
admet-882	192	22	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN
admet-882	192	23	)	)	PUNCT
admet-882	192	24	https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf	https://gco.iarc.fr/today/data/factsheets/populations/900-world-fact-sheets.pdf	PROPN
admet-882	192	25	http://creativecommons.org/licenses/by/3.0/	http://creativecommons.org/licenses/by/3.0/	PROPN